### U. S. ENVIRONMENTAL PROTEcrION AGENCY 

# A 

# EDA PREMANUFACTURE 

# o rn NOTICE FOR NEW CHEMICAL SUBSTANCES 

# lillililiil! ilill

# Ilill iii;:

# IbII!'II;,:1Ii!:I II II·; 11.. 11 ". 1 U :\ 0 (j () ()**~' ~**  (J 

### Enter 

## the total

## number ofpagel in the 

## Premanufacture Notice ·YOIIIII"

### pamde alllalo-..tJo. "'i".eII .... 1111. toIMIo the ectealtWit .. b

.ot ....Ye act•• d.at&.
P.o.

### 36G399fwf. PittablUlh, fA 15lSt-U99, Aft!\. TSo. lIsetFcc. __ 10 or -.ably-w.uble 1oy)'O..Mae_lIble lIIlI"allelf yot! ollefoa yo.Gnaplde tIols (oaa.. )'0••ho.tld IUd lIIe "lulrvdiouMa...llocrr-ualad.. l'tNotI.6cat1o.." (the ....lnldl...... M.uI..aI II n-allable ito.the Toxic S"bstacea Cocolool. Ad (TSeA) lafo_.lo.. Sen10e by caUl., 202.-5s.-t4OC. oc

# I""'., 202.5Sf..5603J. o U I. lIS« fee hubee. 1It.lIlell for lhls .oliee (40 CHt 700.45), IadlGate ia the 1>0_ abon 1M T$-ucrfee IdmllfiGllllo.....ber yo. Jutye ,eaer.&led. Remember. YOllr_rfee ID •••ber ..... also .ppe.IC o.yo.rCGm!Spo..dl_, fee .....Itta.... w'lI" .. __I to. EPA, HQ A.......U", O,......t.lou Be.... eft Il'M·

So-c.alled "bladia,"l>u.. ...., '.d..4e4 Illeo..,lt.o..lth. fona foe)'Oll to iIldlColiU YOllr wiUla,._ 

### u be boIa.dlo ced.t1a ....... yo. lUke I.

### uu. aotlce,. ••dl

.... pmcltKtJo. YOI-c. prota:tlYc

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### nil Optlo." iIlt.ee4e4 to redllClC deLay. tUt lO.tlacl'f

__pan)' the dftelopateal of OlUatorden CIt SI&alfk.uo.t UN ItoIl....

# Ex. I_ 1M_ of ""_plIoaII'ptlGatlo... ",.dl .. TMEA, LVE,. LOIlEX) wbcre oatal.lal_.aIIoa proYI4e4 ill••eIl.oClflaUoa"

..lttdl.., OIl ...........

# ,ttcr wIoca ..... Ag...cy .."............ _"loa IIppllcaUoa, dledd., .......I..' 1>0" I. tIols aotlGt dsla.JIaI. by ....,Ifp",!llbllthe ...... IK« 

## n-**~ct'** ..m.otl'" ito. die**l.fo~1ota** (ace" eIl_1c&I ide.1I1y) reported la llw:fonn. CONFlDENTlAUTY ClAIMS Yo" -..y d.al._, Iafona.alioa 1......oUa! ... CI01l6dcatJ.aL To -.t. d ••

_ ..... *"no. .....tc (X) ....._ftde.tI,a1 boa
- to tll.lafofta.1ota IUt )'0. daI ..

.. e»..6d_UaL To MScrla d.al. I._ oIItUdI ..-t. dcde orbracl<cl the**lalo~)'Oa** cW", .. coafideall&!. U XO!I dal. lafonn.HgA ill the AgtiU.lll maOdc:ptj.al ma Jlalt.aJao ,myfd" I MAlt'"" Balg, pith, IOU" (Jpdudial ..uacbmnt:;). Foe addl(.Ioa&ll"""""''''''' o. elMalla, lafonlt.otlo.... UlafideaU..... reod tlac taltrudlou Ma••aI.



# 00 M.uk 00 If Ally 1.'oon.l_ 1ft till....Ieo " d.w.cd u e»..fid.,ntl&!. Fonn Approved. O.M.B. No. 2OiIUn12. ApptOYlll F.ltpins 1().31 

## AGENCY USE ONLY 

# 03 S[P 22

TYPE Of' NonCE (OedcO.ly Oa.d



# o rn 

# o o o o o LYE Modlflatloa 

# o LOREX Modlfk.atIOlll lSlHlSACONSOUDATEDPMNl 

# 0 Y .. I 01 melltlal.. Il'_li.,. C- .. ...lcatloa , ""I."lred, .,.ler' 

### 0" P"'Ie Jl TEST DATA AND OlHER DATA P&d J - CENUAL INFORMAnON Yo. .ut prori4e the c:umI;IlU:r coCl'td Ocadc&l Ab.. .- (CA) N....e 01 lIle Yoa .1ft ",.,M 10 ..... It aU teat cI.d.a ill :r-r ,--10. or co.1ntI

__ dl_kal ........ce,. ...... II)'O'1 daI. doe Id...UIy _ co.fl4eaII&!. Yo ....y ... toptMWe .......pU_ at aU ........... kaOWll to or ............. 1' ntluuhe _oIUtpcno. 10 .....Il dle.lc&Il4eatlty ....10.......1 ...foryo..,

# ".1

__ataI... 1e loy ,..-.Ifthese"• .1ft """'ell to tic 1t.e.aJIto ...... }'OU ........ 10" will ao( "e a).plde ud 1M ... 

### mw wiU .01 bq'" ."tU EPA elyho_1al .ffeda 01 1M .uafactaa,. p_I"" dlltdbaUo. NceI_IIt. ..**Iato~** A Idtou Ia ...ppod of)'OOII: ..... 10.1_ ...... 'd .... e»••-. -.. ord..,.....,. "fdie _ dInllc&llllbst.mcc. StandAJd releJUCe :r01ll'TS _ fee IdCIIlfflcadOlll a••bcr. Y04I .... 1Ib.1t_ odglul Jltcrat.... dlaIIIou ..., be .......cd foe "'iIlllioe opea IId_Wk adtwo mpla ofthis aotlce I.d.dlas all tell dw. U )'011 d.alllli!d .lAy Utcratlte. 

### emal!kktat dati fwdHa II EnrUsh!. loll,mmad... of4A lalonutlo.... e»ul4catlal. ....ackAftItiud Ulpy mall &180 be ••bmltted. mqsl bu,bmHtcd Iflbq dp apt IVl'£iI II the

## pm IlIe"',",. Y04I.lt.oOl de.uI, JeI_lIf:r wlldhcr ........ o.tlae •• or oa ...

## .....roc- Aloo, P&d D - H'lIMAN EXPOSURE AND ENVIRONMENTAL RELEASE lIle dlealc&lco.podt_ 01. III..l...aed .. riaI ........ d be dlacackriz:cd.. Followl., ate _pi .. 01. _ ......... Iioer d.alL DaI.t aho... d be U the....... several "'lAafadlla,.pl'ClICtS8ln" Of _ opctaUona tobe "coaibe4 I. .......Itfe4 .a»niiag 10 Ihe "'i.I_CIlta01. S'720.5O of llioe hema,factllft P.art II. Mdlou A ....... ofth.._da:, "'P",d.oe tile sectIou ....eeded. NoClfk&loo. Itll.. (40 CHt P&d 7201.. Test DlIU (Oedc Below any lad.dell IathlillOliee) P&d

## m - UST OFAITAOIMENTS Att.c:h addltloa&l ah.NU If the....... "",oap

# .p_ to

# ......-«. q.catl_fully. Y.. Ye Label ucIlco.t1autlo••heel willa lIIe mnapolldlttg 1IOClio. Ur.41tt,. I.Pad. • brito_tal I.e d .. 

# 0 o Otherdata 

# 0 Ul.llsttheM IlUdomeala, Bytat d. oc oIherd ...d lIlA., opUoul Y.. IU&Ic. _ ..cala ,uonu"o. IadHed I.the ..oClcc. • Kulth effecII ... 

# lKl • EaYl

__talcff.... ata Y.. OPTIONAL tNFOIMA11ON 

# 0**Stnoda~act"'lty** mlllo""'" T. d.at.a _t .. lhe,...-i " llioe ._ ...boIt.oacc. 0.. ,.,.. 11 of ...1iI fOl1ft, .paot to_ ...... ,.....,k1e4 foe)'O. 10 Yo. -..y Ittd"deany 1.10_..... 111.)'0. W.aN EPA toe»uldcrI. "".aluiac • PhJ1lk.allOlcaIcal P.,.pertl.. 

# ·00 Y.,. Ole coatrol oftlac ...b .. 1It« deacril>c poUalioe. 

### ,.....,.,..uo...... lOOCJdl.g l.fo

__1oa )'0. -..y ........ IefIldln, llioe ._ .1Ibtbacc.

EPA FORM mO-25 (Rev. S-9S) Replaces previous editions of EPA Form m0-25 

## Company 

# Sanitized 

# IPubUcrepoding burden foe Chis eoUectioa 

### oCWormatioa Is estimabid to**avera~** 110 hours

### per respotue, lndudins time foe reviewing 

### instruc:tiOC1Li searchingedsCingdata IOun:es" gathering

### and znal.ntalnlng theciata 

### neccled. and completing

### and reviewing the collection ollnlonnatioa.. Send commenb rq;atding the burdat atimate«_yother aspect ollhls eoUectioa 01. Won:n.ttioa.lnclud.in& .uu,edoas foe reducing Chis burden, to OdG, Wormatloa Policy BraDCtt.**PM-223~** (,1.5. Envtroamental Profedioa Aptcy. 401 M. St., S.W... W

### It'Ihingtoa. D.C 

### 20&60; and to the Office c M.n.gema.'lt 

### and**Bu~** 

### P Reduction 

### Ad. (2070.0012), Washington. D.C. 2Q5Ql. 

# CERTIFICATION I

### certify that 

### to 

### the best of

### myknOwledge and 

### belief. 1. Thecompany named in Part 

## Lsection A, lubsec:tion la

### ofthis notice fonn intends to 

### manufactureor

### import for A 

### commercial

## pwpose. other

### than in smallquantities solely for 

### research and development, 

### the substanceidentified in 

## Part I, Section

## B. 2. All information provided in this notice is 

### complete and truthful as ofthedateofsubmission. 3. I am lubmitting wlth this notice all test data in my possession or control and a description o(

# an otherdata 

### known to or reasonably ascertainable by me as required by 

### §720.50 ofthe Prcmanulaaure Notification Rule. Additional 

### Certifica.tion Statements: Ifyou 

### are submitting a PMN, Intermediate PMN, Consolidated PMN, or 

### SNUN, check the following 

### user fee certification statement that applies: 

# o The Company named in Part 

### I, Section A 

### has remitted the fee of

### 52500 spedflCd in 

### 40 CFR 700.45 (b), 

### or 

# rn The Company named 

### in Part I, Section A 

### has remitted the fee 

### oE $1000 

### for an Intermediate PMN (defined @ 

### 40 Cf'R 700.4: ) 

### in accordance with 40 

### CFR 700.45(b), or 

# o The Company named in 

### Part I, Section A is a small businessconcern under 40 CFR 700.43 and 

### has remitted a 

### fee of

### $100 in accordance with 40 CFR

### 700.45 (b). 

### If you are submitting a low volume exemption 

### (LVE) 

### application in 

### accordance with 40 

### CPR 723.50 (c) (1) 

### ora Low release and low exposure exemption (loREX) 

### application in accordance with 40 CFR 

### 723.50 (c) (2), 

### check: the following certification statements: 

# o The manufacturer submittingthis notice intends to manufacture or

### import the new chemicalsubstancefor commercial 

### purposes, otherthan in small quantities solely for research and development. under 

### the terms of40 CPR 

### 723.50. 

# o The manufacturer is familiar with the terms of this section and 

### will comply with those terms; and 

# o The newchemical substance (or which the notice is submitted meets all applicableexemption conditions. 

# o If this application is for anLVE in accordance with 

### 40 CFR 

# m.50 (c)(t), the manufacturer intends to

### commence manufacture oftheexempted substance for commercial 

## purposes within 1

### year ofthe date of 

### the expiration of the 30 dayreviewperiod.



### The aa:uracyof the 

### statements you mab in 

### Ibis notice should 

### reflect your best 

### pn!dictioo 

### ofthe 

### anticipated facts 

### repdillg the 

### dMmical

substance 

### described 

### 1Ie.mn. Ally 

### bowing and willful misinlel"pl'eQtioa is 

### SIiljed 10 crimirI.JI 

### penalty pursuant 10 

### 18 USC 1001. -C-o-n-fj-d-en-U-'

### t-11**Si~~re** 

### and title ofAuthorized Official (Original Signature Required) Date 

# x
v 

### Oat.: 

### Signature of agent - (if 

### appUcable)
FORM EPA 7710-25 (Rev. 5-95) Page 2

### II. Person Submitting Notia! 

### On 

## us.)

b. Agent(if applicable) 

## Part I - GENERAL INFORMATION

Oly,

### SCate, ZIP 

### Code
Name olauthorized oltidal 

### Malltng 

### address (number

### and street) Oty.

### SCate. ZIP**Cod~** Telephone



### c Ifyou 

### are submitting

### this notia! 

### as 

### part of

### a joint submission. 

### mark 00 Ibis

### \lox. 

# ---------------iIoJoint 

### Name olauthorizedofficial Submitter 

### (ifapplicable) Mailing address (number 

### and street)

2. Technical 

### Contact 

### On US.) aly. State, ZIP Code 

### Name 

### Company Mailing 

### 1dd.re9s (number 

### and street) aly,State, ZIP Code PositiOll

Telephone Position

Telephone I If

### you have had a prenotice communication (PC) concerning this notice and EPA assigned a PCNumber to the notice, enter the number. Mark (X) if

### none 

# >- 

# D 4. Ifyou

### previously submitted an exemption application for the chemical substance covered by this notice. enter the exemption number assigned by EPA. Uyou

### previously BUbmitted. a PMN for this substana! enter the 

### PMN number 

### assigned

### by EPA (i.e. withdrawn orIncomplete). --)IJo ..... Ifyouhave submitted a n.otl.oe 

### 01 Booa fideIntent to manufacture or import for the chemicalsubstanoe covered by this noUce. enter the notice number assigned by EPA. 

# >­ Mark (X) if none 

# >- 

# 0 Mark 

### 00**--~~** 

# D if none 

# D Manufacture 

### Import Type ofNotice
- Mark 00 1. 2. Only Only 3. Both 

# D Binding OpUon 

# D 8indingOption 

# D Mark (x) Mark(x) FORM EPA 7110-25 <Rev. S-9S) Page 3 

## X

## Part'l
- GENERAL INFORMATION
- Continued

to any llcm you chim as 

### canflclentW. Complete eiChec Item 1 CO.. 1 01" 2 Alb.tancu, 0( 2 (Polymect) .. appropriate. 

### Coatpldc aU other ttema. 

### Uanotbet' 

### penon wtJl Nbadt chemI.a.lldentitylnformation 

### loe you (loe dCher Uan 1 oe 2). markOQ the boll: at 

### the 

## rJP.t. 

# 0 the 

### and Iddmls 0( that 

### In. conlinuadoo

### sheeL 

# > 1. 

## a.•• 1 01" 2 ch_lcal8Ubltaclcc.flor defi.nltioas 0( dass t 

### and c::lus 2 subslanCll!S, 

### _the 

### "'.truett-.Marlaal) 

### a. Class 01 substanoe - M.ui: 00 

# til Oa.ss 1 

### or 2 

# D Oass 2 b. 

### 0u:mi.eaJ. name (Currendy c:orted Oumdcal Abstracts (CA) Name that Is c:onslstCllt with 1!:iCA Inventory Ii.stiagslor IIlmUac IlUbstanaes. For

## a- 1 Nbstanca a CA index Namemust beprovided. For 

## aus 2 substll.!:lO!S dCher a CA 1ndC'JC Name orCA Preferred Name be 

### pRlYIded. whicheveris appropriate bued on CA 9C1 nommdature rules 

### and conventions.).



### c. Please Identify which method 

### :you used to devdop oe obtain the sped.fied chem.icallndenlity lnfonnatioo reported 

### In this notice:

(check one). 

# [!J Method 1 (CAS Inventory 

### Expert 5et'vic:e - a copy of the Identification 

# DMethod 2 (Other Source) report obtained from the 

### CAS Inventory Expert Service must be submitted as an attachment to thi$ notice) 

### d. Molecularformula and

### CAS Registry Number (if a number already exists tor the substance)
CAS'

e. For a da•• l substance, provide a complete and o:xrect chetn.lcal structurediagram. 

### For a cia.. 2 substance
- (1) Ust the immediate precursor substances 'WIth thdrrespectiveCAS Registry Numbers. (2) Describe the nature ofthe reaction or

### procas. (3) Indicate the range ofcomposition and the typical composition (where appropriate). (() Provide a axrectrepcesentative oe partial chemical structurediagram. ascomplete IS can be known. ifone can be reuonably 

### ascert.a1ned.



# D Mark (X) this box if you attach a continuation sheet FORM EPA 771().25 (Rev, S09S) Page (

## Part I.- GENERAL INFORMA nON
­ 

## Continued**~** Section B - CHEMICAL IOEN1TfY INFORMA nON
- Continued 2. Polymen (For. definldon of

### polymer, IJCe**th~** I".lnaction. Manual)

# ~:I

a. Indicate the number-average 

### weight ofthe lowest 1llOl.ecular weight c:xxnposllion olthe polymer youIntend to manufacture.

.lndk:ate awd.m.um weight pera:nt

### oflowIllOlecu1ar weight 

### .pedes (not Indudlngres1dualmonomers, reactanb, orsolvenb) below SOO ;wi below 1,000 absoluteIllOIecular weight olthat ClOInposltion. DeKrlbe the method. 01 DltulU'Cment octhe 

### baN foe 

### 7-r e.tim.atel: 

### ere 

# 0 OdwlrD : (Spedly> D lawat l\IUI\!Iua--aeanoI«uI.ar

### W'dihc: U) IIWdI:nwn weight 11; below SQ.'l1l\OlcQd.ar waght 

## NA un awdmwnW'<i&ht below 1000 1I'IOl«u1u

### -'&he: 

# o Mark ()O this box II you_attach a continuadon .neet. b. You must make separate coafidentlality daims foe monomer or otherreactant identity. composition Wonnation, andresiduallnforma!ion. Mark 

### 00 the -Con/idendal- box next to anyitem you claIm as coafidential. . (l) - Provide the spedficd:lem.lca1 name 

### and CAS 

### Regbtry Number (Ifa numberexists) oleach monomer orother reactant used In the manufacture of 

### the polym«. (2) - Mark (X) this columnII entry In column

# m Is cnnfidential (3)
- Indicate the typical weight percent ofeach monomer or other reactant In the 

### polymer. (4)
- Mark 00 the Identitycolumn if)'Oll want a monomer oeotherrcactanlll.1td at two weight percent or Ie•• to be luted at part of the polymerdellCription on the TSCA ChemicalSubatance Inventory. (5)
- Mark 

### 00 this column Itentries In columN (3) and (4) are confidentW. (6)
- Indicate the maximum weight percent oleach IllOMmCf orother reactant thaI may be present as a resldu.alln the polymer as manufactured for commercial

### purposes. (7)
- Mark (Xl this column Itentry In column (6) is cnnlidential Monomer or other reactant and CAS Registry Number ConCi- Identity 

# Conn- Maximum

# I~

# ~I denlial "", .." .... Itl"n Mark 00 denlial residual 

# m (2) (3) (4) (5) (6) (1) 

# ,. ,.. 

# ,. ,. -'" 

# ,. 

# ,. ,. 

# ,. ,.**~** 'L 

# ,. 

# ,. 

# o Mark (X) this box Ityouattach.continuation .neet. c. Please identity which method. 

### you used 10 develop orobtain the specified chemlcalldentilyinformationreported In this notice. (check one).



# o Method. 1 (CAS Inventory 

### Expert Service - • copy ol theidentiftcation report 

# 0 Method. 2 (other source) obtainedfrom CAS Inventory ExperlServIce mustbe submitted as an attachment to this notice) d. The currentlycorrect OIem1ca1 Abstracts (CA) name for the polymer that is consistent with TSCA Inventorylistings for simUar 

### polymers.

e. Provide., 'l>r!"'CI representativeor partial chemical struclUre diagram. as complete as can be mown. if one can be reasonably ascertained.



# o Mark(X) INS box if you attach a COf\linuation ,hC<i!!. PageS FORM EPA 7710.25 (Rev. 5-95)

## Part I - GENERAL INFORMATION
- Continued**~** Section B - CHEI'dlCAL IDENTITY INFORMATION
- Continued 1 Imp.cU_

e..) -IohaIU)'....to •..,.dty Uo.... , H _ •

# .ob., ...tldp«ed 10'" pnMIllla .... dr...tcal .... fad:veof (orCDao-.:tal ............. ho'li4ellle CAS 

### &ecWrJ N...berlf.vaIW>le. V ....roe Are ..waUfted ......... nIoU

### -..w.ufw.­ (I)) -EstI1IUII& IM ......._ welpa'Jr. ofeadlllllplldty. If 1Il_ Me .aIdcadfIecI ..,..,..... .......... Waf

### -'lioa 'Jr.. lInpurity and CAS 

### Regbtry Number Maximum 

# :-. (a)

### per~

# '" '"

. 

# '" 

# '" '" 

# '"

... 

# o Mark (X) this box if you attach a continuation sheet. 4. SYllollym_
- Enter Ally chemical synonyms foe the new cheadcal:rubstance Ident1f1ed in IUbsedlon 1 or 

### 2.

# ~I

- 

# X 

# o Mark (X) !his box 

### Iiyou attach a continuation sheet. S. TRde identification
- List trade names for the new chemical Identified in aubeection 1 or 2. 

# o Mark 

### 00 this box 

### Ii you attach a continuation sheet. 6. Cellule chemical name - Ii you daJ.m chemical identity as confidential.. 

### you 1I\1Iatprovide a generic chemical name for 

### your substance that reveals the specific chemical identity ofthenew c:bemic:allUbItana! to the maximum extent possible. Refer to the TSCA O\emic.al Substance Inventory, 1985 Edition, Appendix Bfor guidance on developing , , generic names. 

## Substituted Benzamine thio-ether 

# o Mark

### 00 this boxil you attach a continuation sheet. 7. Byproducts
- pesaibunybyproducts resulting from themanufacture. 

### proc:esslng.. use, or 

### disposal 

### 01 the new chemical subslanc:e. 

### Provide the C 

### \S Registry

### Nuinber ifavailable. Byproduct CAS RegistryNumber 

# de;:

# ~i (1) (2)



# 0 Mark (X) this box if you atta<:h a continuation sheet. FORM EPA n}()"25 (Rev**~·95)** P;age6

## Part I - GENERAL INFORMA nON
- 

## Continued

.. Section C - PRODUCIlON,IMPORT, AND USE INFORMATION: Mark 00 the**~Confidenlial'** box next to anyItem you dUm as coafidentIa.I. L Production volume
- Estimate the 1DIximum production volume

### during the 

### first 12 months ofproduction. 

### Also estimate the maximum production volume 

### for any 

### consecutive 12-month

### period during

### the 

### first 

### thm: years ofproduction. 

### Estimates should b eon 1()()<K, new

### chem.iea.l substance

### basis. 

### fqr /l1..#w 

### Volume E:umption 

### qpliazlion. 

# if )'0"

### choose to 

## Irtmt: your lfDtia 

### tz1l1icnDtr

### produc iorr 

### 'DOlume'MII 10,DOO kg/yt, 

### t>p«ify ,he 

### f1Oi"

___ 

### k (r) 

### in the tnrlllillg

# ""x. If gnrnUd, you«re 

# """rill14 fhU 

### wlllme_ Maximum first 12-month production 

### Ckg/yr) Maximum 12-month production 

### ()(:g/yr) 

### Confi­ liadu**(100~** new 

### chemical substance buis)**(100~** new chemical substance

### basis) dentia1

## ~, ; 

## X 2­ Ule lnlormatiOl1
- You must 

### maIce separateexmfidentiality dalms foe the description 

### 01 the category 

### 01 use, the percent ofprodudion volume devoted to each category, the formulation 

### 01 the new substana, andother use Wonnalion. Mark 00 the "Con1I.dendal- Box next to anyitem

### yOll claim as ronfidentiaL a. (t) - Desaibe I*:h intended category of Wfe ofthe newchemical substance by function and appUcadon. 

## a) - Mark 00 this column Ifentryin rolumn (I) Is confidential busin_ information (CBl). (3)
- Indicate 

### your willingness to have the information provided incclumn 0)binding. . (4)
­ Estimate the 

### percent oftotal production foe the ftrst three years devoted to each category of Wfe. (5)
- Marie 00 this colwnn if entry in rolumn (4) Is confidential businessinformation (CBl). (6)
­ Estimate the peromtofthe new substance as formulated in uUxtures,**~ons,.** emulsions, lIOI.utions, 01' gels as manwactured for commercial 

### purposes at sites under your exmtrol associated with each eategory of Wfe. (7) - Marie 00 this column 

### 1£ entryin ro\wnn (6) Is confidential bustn_Wormation (CBl). (8)
­ Indicate 'J{, of producl volume expectedfor the listed "use- sectors. Mark lX\O('e than one box 

### 1£ appropriate. Mark O() toindicate 

### your wt1lingness to havethe use type provided in (8)binding. (9)
­ Mark 00 this column 

### ifentry(ies) in rolumn (8) Is (are) confidential business Information (CBl). 

### Category 01 use (1) 

### CBI ."..IIa, Produc- 

### CBI 'J{,1n 

# !CHI 'J{, of substance expected 

### per Wfe**~I** (by function and application i.e. a dispersive dye for 0pti0tI lion 'J{, Form­ (8) M.arit.: !,.) ulation finishing polyester fibers) [Site- 

### il..On- Indus- 

### Com­**~iIlclinl** 

## a> (3) (4) (5) (6) (7) limited 

### swner Irlal mercia] Option (9) 

## X**~** 

## X 

## X 'JI, 

### i'­**~.** 'JI, 'JI, 'JI, 

# '"**~** 

# '" .,. 'JI, 'JI,**~ ~**  'JI, 

### "If 

### you have identified a 

### "consumerM use, please provide on a continuation sheet a detailed description ofthe use(s) of

### this chemical substance in consumer products. In addition include estimates of the concentration of 

### the new

### chemical substance as 

### expected in consumer products and describe thechemical reactions by which this substance loses its identity in 

### the consumerproduct. 

# o Marie (X) this box U you attach a continuation 

### sheet. b. Generic If

### you dal.m any

### category of Wfe desaiption in lIUbsection 2a lIS confidential, enter a 

### generic desaiptlon of that

use category. 

### Read the Inlltruction. Manual for examples

### 01 

### peri<:use descriptions. deKription 

# Raw Material 

# ..J Mark (X) this box ifyou atl.lch a continuation sheet. 3. Hazard Information
- Indudein the notice a copy of reasonable faaimi.\e of any hazard warning al.ltement, label, rnatt!rlal safety data sheet. 

# .....**I~**

orother information which wl1l beprovided \0 any 

### person who is reasonably likely to be expo6ed to this substanoe regilding protective

### ~- 

# n equipmentor practices foe the safe handling. transport. use. ordisposal of the new substance. List in part III hazard Wonnation you Indude. Mark (X) this box if attach hazard information. FORM EPA 771()'25 (Rev. 5-9S) Page 7

### PMN Page 8 ; 

### Page 10 of 18 box next to any item you 

### Complete section A for each type ofmanufacture. processing, or use operation involving the new chemical substance at industrial sites you control. Importers do not have to complete this section for operations outside the 

### U.S.; however, you may still have reporting requirements if or use these " ........, ti ....

# n. the will occur.
Site address (number and slreet)**-------------------------,~** .J 

### Ifthe same operation wit! occur at more than one site, enter the number ofsites. Identify the additional sites on a continuation sheet, and ifany ofthe sites have significantly different 

### 1 production rates or operations. include all the information requested in this section for those

I. Batch 1. Continuous Maximum (100% _ chemical Hours/day**.~.)** d. Process description Marl< (X) to indicate your willingness to have your process description binding. 

### Use Batches/year Days/year 

# [TI [TI 

# D (I) Diagram the major unit operation steps and chemical conversions. Include interim storage and transport containers (specify- e.g. 5 gallon pails, 55 gallon drum. rail car. tank truck. etc.). (1)**Provid~** the identity. the approximate weight (by kg/day or kglbatch on a 100"10 new chemical substance basis). and entry point ofall starting materials and feedstocks (including reactants. solvents. catalysts. etc.), and ofall products. recycle streams, and wastes. Include cleaning chemicals (note frequency ifnot used daily or per batch.). (3) Identify by number the points ofrelease. including small or interminent releases, to the environment ofthe new chemical substance. Ifreleasing to two media .llhe same step. assi,gn a second release number for the second medium.

Mark (X) this box if allach a continuation sheet. EPA FORM 7710·25 (Rev 5·95) Page 8

## Part II ­ HUMAN EXPOSURE AND ENVIRONMENTAL RELEASE
- Continued**~** Section A ­ INDUSTRIAL SITES CONTROLLED BY TIlE SUBMITrEK
- Continued 2. Oc:capadooal
- You. must make:a:=te coalidentialityda.Ims for the detaiptlonofworker ectMty,physiadform ofthe new

### chemical

substance.number ofwarken expo..t.. and untianOf activity. Mark 00 the -CoNI.denW- box next

### to any itam you. daim atconfidential..

. (l)
- 

### Desaibe theactivities

### (e.g. bag dumping. 

### tote fWing. unloading

### drums, 

### umpling, deanlng.. etc.) 

### In whlc:h wod:en may

### be exposed 

### to the 

### substance. (2) - 

### Mark

### 00 thiscolumn 

### itentry 

### In column (1) is c:o.nfidential 

### business Information (CBI). (3)
- Describe anyprolective

### equlpment and engl.neerlngQ)fttrois 

### used to

### protect workers. (4) and (6) 

### -Indlcate

### you willingness ID have 

### the information 

### provided incolumn (3) or (5) binding. (5) -Indicatethe

### physk:al formes) of

### the new c:hernI.calsubstance (e.g. 

### lOUd: aystal, 

### granule. powder, or dust) and 'I. new

### chemical substance (if pal 01 a mixture) at the time

### 01 

### exposure. (7)
- Mark

### 00 thiscolumn 

### itentry 

### In column (5) is amfidential business information (CBI). (8)
- Estimate the muimumDumber 

### 01 'WOl'kers involved in eac:h activity lor 

## .n lites COIllblned. (9)
- Mark

### 00 this column 

### itentryin column (8) is confidential 

### business information (CBI). (10) and (t l) - Esthnate the D'Wdmum duration ofthe activity for any worker In hours 

### per dayand days

# h. year. (12)
- 

### Mark 

### 00 this column 

### itenlries incolumns (10) and (11) are confidential business information (CB ). Wor1ca-**acti~** 

### CBI Protectlv" Eq.l.....-u .WIIlI 1'1l),IlQ110CUl(.1 Bladla, CB[ 'of CBI Maximum duration 

### ;:Sl (e.g. bagdumping. drums) Ea,I--'1lI

### Coac.o"

# ~~w (e.g.aolid:powdet) 

# =-c:, Worbn and Dew ExpaNd Mrs/day 

### Days/yr 

## m m r.n (()**auba~c:c** ll.} l'7\ (8) (9) (10) 

## nn 12)



### .. 

# ..**~ -!.-~-**  .... -­ 

### X" Y 

# - X

.**~**


# 0 Mark (X) this box 

### ityou attach a a:mtinualion sheet. 3. EnvirorunenlalR.eleue and DbpoIal- You must make separate

### CIOl\fiden tiality

### claims for 

### thereleaseDumber and the amount 

### of the 

### new chemi**~**

substanc:e releaxdand otha- release and disp<ll$&l inlormalioa. Mark 

### 00 the -Confidential- box next to each itam you dalm as confidential.. (1)
- 

### Enter the number of -=II rel_point identified in the process desaiption,. part II, section A, subsection Id(3). . (2)
- Esthnate the amount ofthe new substance released (a) dI.n!ctly 

### to the envlrorlment or (b) intocomrol teclmology (in kg/day or leg/batch). (3)
- Mark 

### 00 thiscolumn 

### it entries in colUlJUla (1) and (2) are CIOnfidenUal business information (CBI). (4)
- Identify the 

### media 01 release Le. stack air, fugitive air (optiooaJ..-lnsUuction Manual),lUriace water, on-site Ofoff·lite land or indneratiOl • POTW. orother (please !!p!d.fy) to which the new substance will be reJeued. from thatreleasepoint. (5)
- 

### a. Describe control technology, ifany, ,and oontrol efficiency that will be Uged to limit thereleaseofthe new substance to the environment. Forreleasesdisposed ofon land,. characterize the disposal methodand state whether Itis approved. for

### disposal 01 RCRA hazardous waste. 

### On a c:ontinuatl.on 

### .beet,foe each site desaibeany additional disposal methods that wiI.l be WIed and whether the waste Is sub)ed to HCOndary Of ta'Uaryon..te treatment b. Estimate the amount rel.eased to the environment after CIOntrol 

### technology (in 

### kg!day). (6)
- Mark 

### 00 this column 

### itentriesin columns (4) and (5) are

### ClOIIfidenUal buIinessinformation (CUl). ('7)
- Identif), the destination(,) ofreleases to water. Please supply NPDES (National ponutant DbchargeElimination System) numbers foe 

### dire< dischargers or NPDES numbers of the POTW (PubUdy Owned TrcalmentWorks). Mark 

### 00 it the POTW name orNPDES , Is confidential business infonnatioo (CUI). 

### Release Amountofnewsubstance 

### CRI ,Melfiaor Control technology and 

### eltk:lenc:y (you mayWish tooptionallyattach efficiency data) 

### ;:Sl Number rpl"" If'd release I .......



### (U (2a) (2b) .... lIfdt.1I (3) (4) (Sa) : w.ut6<l (Sb) 6) 

## 1 ',.;; I 

# K X I li' II t 

# ..... f-­ I I I I I I I I (7) Mark (}Q the 

# o POlWprovide name(s) below:: CBI 

# o Navigable 

# o Other SpeciEy providR NPOES •**~I** destinalion(s) 01 

# - wata-way releases to water. 

# o Mark (X) this box ifyouattadla continuation sheet. FORM EPA 7711).25 (Rev. 5-95) Page 9

## Part 11- HUMAN EXPOSURE AND ENVIRONMENTAL RELEASE
- Continued**~.** 

### SectionB - INDUSTRIAL SITES CONTROLLED BY 

### onrERS Completelledion B foe 

### typical

# processlnJ: use operations Involving

### the new c:hmUc:a1lUbitance lit lites

### you. do 

### not mntrol.Jmporters

### do not haw to c:omple«e this lledion foe 

### operatioN ou 

### the U5...

### however, you mutt

### npext_y proce!IIIIIng oe uteactivities 

### after import. 

### See the lNtructions 

### Manual OJmpIdc ...... 

### te 1tdi7tt

# B!". ctldt

### type

## of

# proassmg,at' IUe 

### opaaticm

# in""'., rile IIt1I1

### dIt:mit:al 

### Ifthe same operaUOft Is 

### penorn ed at more 

### than onelite

### desaibe the typical operation <XlmII\Ol\ to 

### these Illes. 

### Identify addilioaalililes

### Oft • 

### ClOaCinuattoa 

### aheet.**~.** OperalioCl DCKripti_
- To daimWormation in this IIedion .,mafide.ntial. d.rdeoe bracbt the

### tped8c WOID'I&I1oa that 

### you. claim as

### ClOnfidentiel (1)
- Diagramthem.Ijoc urdtoperation 

### .ups and

### chemical. conversions, includingIntaim and transportcontalnoen 

### (,pedfy­ 5 gllllon PI Ib, SSgalJon

### c:trums. rail

## c:an. taDk 

### truc:b. etc). 

### On the dlagra.m.ldentify

### by letter and bri4!Gy d-=ribe

### each worker IIdlvtty. (2)
- 

### Provide the

### Identity, the approximate

## welsht (by kg!

### day orkg/batch. on an lOO'J1, new chemical. IUbKance bub), and entrypoint of

### aU feecUtoc::b (lnducling n!Actants, IOlvents and ... 

# =ts. etc) and of

### aU products. reqde streams,and wastes. Jndudedean.lngchemicals (notefNqUelC)' II DOt used daily oe p« batch). (3) -Id 

### by 1\Wl\ba' thepointsof

### ftIease. induding ImaIJ oe Inllennltllenl releases, to 

### the envlro_t of

### the newchemicalllUbstance. (4) Please enter the • 

### 01 lit_ ( rememba'to Identify the 

### IocatiOl\S ofthese litaon a continuation theet) : 

## 0
, Ol.les 

# .



# o Mark 00 this box II

### you. attach a continuation sheet. Z. 

### Worker 

### ExpoeurrlEnYiroamallall.dute (1)
- From the diagram above. provide the letter for: each worker 

### activity. Complete

### 2-8 foe each worker activity dec:ribed. Q)
­ Estimate \he numberof workers exposedfor: aU ates oombined. (4)
­ Estimate\he typlcal. duration of p«worker In (II) hoW'll p«

### day and (b) 

### days per 

### yeas:. (6)
- Desaibe physlcal form 01 exposure and "" newchemical. substance 

### Of In mixture), and 

### any protectiveequipmentand engineeringconlrois w 

### i!d to protect workers. (7)
­ Estimate \he percent ofthe new aubetance as formulated when packaged orused ., • final product. (9)
­ From the

### process dio'Igram above, enter the number ofeachrelease point. Complete 9-13 for each reJ,e.a,e 

### point Identified.. (lO)
­ Estimate the amount 

### 01 the I\eW substancereleased (Il) 

### directly to theenvironment or (b) intocontrol

### technology to the enviro_t (inkglday orkglbatch). 

### (12)
­ Describe medla ofreleaei.e.. std air, fuPtive air (optional__Instructions Manual), surface water, on-lite or: olf-lite

### land orIncineration, P01W.orother 

### (specify) and mntro( 

### technology, U

### any. that 

### wDl be 1.-:1 to limit the release ofthe new subsbnce to the environment. (14)
- Identify byprodudswhich may rendt 

### &om the operatlOl\. (3), 

### (5), (8). (11), (13) and (15) - Mark 00 this column If any ofthe prooeed.lng entries are conlldential business 

### informatiOft <CBD. Letter 

### 'ol CBl Duratlon 

### CBI Protective 

### Equip. 

### I 'fom CBI 

### Release Amountol 

### CBI Media ofRelease 

### ;:Sl

01 Workers of EngineeringControlsl fonn- Number New &cControl Ad- 

### Exposed Exposure Physic:al 

### Form and. "" ulalion SubstAlnce 

### Technology ivity new substance 

### ReIeeed I (lOa) : (lOb) (t) (2) (3) (4a) 

### I (4b) (5) (6) (7) (8) (9) (t1 

### (12) 13) I 

### I I I 

### I I I 

### I I I 

### I I 

### I 

# . I I I 

# J J I 

### I I 

### I I I (14)
- Byproducts: 5) 

# o Mack (X) this box if you attach a a>ntinWilion sheet. FORM EPA mO-25 (Rev. 

### 5-95) Page 10

## OPTIONAL POLLUOON PREVENTION INFORMATION To claim inCormation in this section as confidential circle orbracket 

### the specific information 

### that you claim as 

### mnfidential.



## .. ' 

## In this 

## section you may provideiIuonnation not reported elsewherein this fonn regarding your efforts to reduce orminimize 

## potential risks 

## associated with activities surrounding manufacturing, processing, use and disposal ofthe PMN substance. Please include new infonnation pertinent to pollution prevention, including source reduction, recycling activities and safer processes orproducts available due to the new chemical substance. Sourcereduction includes the reduction in the amountor toxidty of chemical wastes by technological modification, process and procedure modification, productrefonnulation, raw materials substitution, and! or inventory control. Recycling refers to the reclamation of useful chemical components from wastes that would otherwise be 

## treated orreleased

# as air 

## emissions or water discharges, or land 

## disposal. Descriptions ofpollution prevention, source reduction and recycling should emphasize potential risk reduction subsequent to compliance with existing regulatory requirements and can be either quantitative or qualitative. The EPA is interested 

## in this infonnation to 

## assess overall net reductions in toxicity or envirorunental releases and exposures, not the shifting of risks to other environmental media or non--environmental areas (e.g., occupational or consumer exposure). In 

## addition, information on the relative cost or perfonnance characteristics of the PMN substance to potential alternatives may be 

## provided. All information provided in this section will be taken into consideration during the review of this substance. See the revised Instructions Manual that includes a Pollution Prevention manual for guidance and examples. Describe the expected net 

### benefits, such as (l) 

### an overall reduction in risk to human health or the environment; (2) 

### a reduction in the volume manufactured; (3) a reduction in the generation of waste materials through 

### recycling. source reduction orother means; (4) a reduction in potential toxicity or human exposure and/or environmental release; (5) an increase in 

### product perionnance, 

### a. decrease in the cost of production and/or improved operation efficiency ofthe new chemical substance in comparison 

### to existing chemical substances used in similarapplications; or (6) the extent to which the new chemical substance maybe 

### a. substitute Cor an existing substance that poses a greateroverall risk to human 

### health orthe environment.



# o Mark (X) this box if you attach a continuation sheet.

fORM EPA 7710-2S (Rn'. S-9S1 P"g-e 11

## Part III -- LIST OF AITACHMENTS Attach continuation sheets for sections ofthe form and test data and other data (including physicaVchemical properties and structure/activity information), and optional information after this page. Clearly identify the attaclunent and the section ofthe form to which it relates, ifappropriate. Number consecutively the pages ofany paper attaclunents. In the column below, enter the inclusive page numbers ofeach attachment. Electronic attachments can be identified by filename. Marie (X) the "Confidential" box next to 

### any attachment name you claim as confidential. Read the Instructions Manual for guidance on how to claim any information in an attachment as confidential. You must include with the sanitized copy ofthe notice form a sanitized version ofany attachment in which you claim information as confidential. #I Attachment name Attachment Filename Attachment Contipage number(s) dential 1 

### Physical and Chemical Properties Worksheet 1 

# D 2 

### Material Safety Data Sheet 2-3 

# D 3 

### Acute Oral Toxicity Study 4-5 

# D 4 

### Ames Test 6-7 

# D 5 

### Skin primary Irritation Study 8-9 

# D 6 

### Skin Sensitization Study 10-14 

# D 7 

### CAS Inventory Expert Service 15-16 

# D 8 

### Infrared Spectra 17 

# D 9 

### H-NMR spectra 18 

# D 10 

### HPLC Spectra 19 

# D D D D D i 

# D D D D D D D D D 

# D [ 1 Ma.rk (Xl this box if you attach a continuation sheet. Enter the atlllchment name and number. EPA FORM 1710-25 (Rev 5·95) Page 12

# ATTACHMENT 1 

# Physical and Chemical Properties Worksheet

Cover Sheet
- Not Included in Page Count 

# 13

### PHYSICAL AND CHEMICAL PROPERTIES WORKSHEET To assist EPA's review ofphysical and chemical properties data, please complete the following worksheet for data you provide and include it in the notice. Identify the property measured. the page ofthe notice on which the property appears. the value ofthe property. the units in which the property is measured (as necessary). and whether or not the property is claimed as confidential. Ifthe attachments are electronic, give the attachment nwnber (found on page 12) at (b). The physical state ofthe neat substance should be provided. These measured properties should be for the neat (100"10 pu.re) chemical substance. Properties that are measured for mixtures or formulations should be so noted ('Yo PMN substance in 

### -l. You are not required to submit this worksheet; however. EPA strongly .recommends that you do so. as it will simplify review and ensure that confidential information is properly protected. You should submit this worksheet as a suPlllement 10 your submission oflest data. This worksheet is not a substitute for submission oflesl data. Property Mad{X Page Value Mcasurcdo Conti· if nwnber Estimato: 

# ....... (a) provided (1)) (c) MortlXI (MorEl (41 

### Physical state ofneat substance 

# 0 D . (s)

# ~(I) D(g) 

## M 

# 0 Vapor pressure 

# D 0 @ Temperature 

### °C Torr Density/relative density 

# 0 glcm3 

## M 

# 0 Solubility 

# D @ Temperature 

### °C 

# 0

Solvent gil 

### Solubility in water@ Temperature 

### °C 

# 10 0%


## - gIL 

## E 

# 0 

# - Melting temperature 

# D °C 

# 0 Boiling! sublimation temperature@, torr pressure 

# 0 °C 

## M 

# 0 Spectra 

# 0 See Attachments 

# 0 Dissociation constant 

# D 0 Particle size distribution 

# D 0 Octanol! water partition coefficient 

# D D Henry's Law constant 

# D 0 Volatilization from water 

# D 0 Volatilization from soil 

# D 0 pH @ 

### concentration 

# D 0 Flammability 

# D 0 Explodability 

# D 0 Adsorption! coefficient 

# D 

# ]g] Other
- Specify 

# D 10 Other - Specify 

# D D D MIII1c (X) this box ifyou attach. """,..

### "",t"", sheet En\ef !he attachment"""'" and number.

t •

# ATfACHMENT 2 Materials Safety Data Sheet

Cover Sheet
- Not lncluded in Page Count 

# 15

# Material Safety Data Sheet Date Prepared: March 11, 2003 Section I - Material Identification Trade Name: Chemical Family: Industrial Specialty Chemical Importer: .• IC. 

### Product Information Telephone number: Emergency Telephone Number: CHEMTREC 1-800-424-9300 Section" -Ingredients Information

.- ,., '" t"**......~"** 

### >97% OSHA PEL and EPCRA 3021372 N/A Section III - Physical Characteristics Specific Gravity : No information found Solubility in Water : Not soluble pH value : Not applicable Odor : None Appearance : Pale tan liquid Melting Point : No information found Boiling Point : Over 200 degree C Section IV - Fire and Explosion Hazard Fire and Explosion Hazard : No hazard Extinguish Media : Dry chemical, C02. water or foam. Fire Fighting Instructions : Keep personnel removed and upwind of fire. Wear self-contained breathing apparatus. Section V - Reactivity Data Stability : Stable Incompatibility: Avoid strong oxidizing agents. . Decomposition: Carbon monoxide, carbon dioxide, nitrogen oxides, sulfur oxides Polymerization: Will not occur.

### \ 

### page 2 Section VI - Health Hazard Data Heath Hazards: low hazard in normal handling. Acute Oral Toxicity: lD50 >2.000 mg/kg (rats) [Chemical Safety) Ames Test Negative Skin Irritation: Mild irritant**~.I.1.** 

### U.5 (gUinea-pig) [Chemical Safety ) Skin Sensitization: Negative (guinea-pig) [ Fuji Internal lab ] Carcinogenicity: This chemical is not listed by NTP. IARC or OSHA as a carcinogen. Sign and Symptom of Exposure: No information found. First Aid Procedure: In case of eye or skin contact, immediately flush with plenty of water for 15 minutes. With eye contact, get immediate medical attention. If inhaled, move to fresh air. If not breathing give artificial respiration. If swallowed, do not induce vomiting and get immediate medical attention. Section VII - Precautions for Safe Handling and Use Steps to be taken in case material is spilled: Scoop up carefully and place in closed container. Consult with federal, State and local Regulatory Agencies for appropriate disposal methods. Waste Disposal: Consult with Federal, State, and local Regulatory Agencies for appropriate disposal methods. Precaution to be taken in handling and storing: Keep container closed and keep in cool area. Avoid inhalation and contact with skin and eyes. Wash thoroughly after handling. Section VlII- Control Measure Respiratory Protection : Not normally required Ventilation : Mechanical exhaust recommended. Protective Gloves : Latex type. Eye Protection : Protective eye glasses or goggles Protective Clothing : Suitable protective clothing is required. Others : Shower and eye-wash. Section IX - Shipping Information Hazard Class: Not regulated by DOT. UN Number : 

### N/A Packaging : 

### N/A NFPA Rating: H-1 F-O R-O



# /

# ATTACHMENT 3 

# Acute Toxicity Study

Cover Sheet
- Not lncluded in Page Count 

# /8

## Acute Oral Toxicity Study in Rat with Test Period: 1112612002
- 1212212002 Report prepared: 1212612002 Test Facility: Chemical Safety Test Center. Saitama Laboratory 25-1, Oh-azakuroiwa, Yoshimicho, Hikigun, Saitamaken. Japan Test Supervised by: Yoshihiko 

# Kamba Summary Acute oral toxicity of provided by**:o~,** 

## Ltd. was studied using male Sic:Wistar rats. The test substance was dispersed in corn oil (the dispersion concentrations were adjusted to keep the feed rate at 10 mllkg) and was administered through a metal stomach tube. Results: Dose (mg/kg) Mortality Unusual Behavior LOSO (mg/kg) Classification 500 

# o None >2,000 Less than Mild 2000 

# o Sluggishness 

## Based on the above, the acute oral toxicity ofBEHTA is classified less than mild, using the method presented by Hodges et al (American Industrial Hygiene Association Quarterly 1949). Purpose ofStudy Evaluate the acute oral toxicity in rat of
- -- -- orovided by Test Substance and Test Method Test Substance: Liquid. The dose levels of500 mglkg and 2000 mglkg were selected. The test substance was dispersed in corn oil (the dispersion concentrations were adjusted to keep the feed rate at 10 mllkg). Four weeks old Slc:Wistar male rats (breeder: Nihon SLC) were obtained from Sankyo Lab Service and were kept for six days for acclimation. The average body weight ofthe test animals was approximately 100 g when the study started. 

# l<f

## The animals were kept in a study room at temperature 23 

# ±2 degree 

## C, RH 50 

# ± 10%, ventilation
- air replacement. 17 timeslhour, and with illumination 12 hours/day. The animals were kept in plastic cages and were fed solid feed (MF: Oriental Yeast Industries) and water freely until 16 hours prior to the administration ofthe test substance. Only water was 

## given between 16 hours prior to and 3 hours after the administration. A group offive was selected for each dose level and control. The test substance dispersion was administered through metal stomach tube. Observations ofthe animals were made immediately after the administration through 6 hours after the administration, then every day until the 

## 14th day. 

## All animals were put to death after the 

## 14th day and autopsy was conducted. Results Table 1. Mortality

Dose tlofanimals day day day day day day day day day (mglkg) tested 

### 1 2 3 4 5 6 7 8 14



### 500 5 

### 0 0 0 0 0 0 0 0 0 2000 5 0 0 0 0 0 0 0 0 0 

## Table 2. Body Weight Change Unit: 

### g

Dose 10 number day day day day day day day (mglkg) 0 1 2 3 4 

### 7 14

500 1 93 101 108 115 118 

### 134 175 

### 2 97 107 111 115 

### 117 132 173 

### 3 98 106 111 117 122 

### 138 179 4 101 110 115 121 

### 126 142 185 5 98 107 112 118 123 140 180 Average 

### 97.4 106.2 111.4 117.2 121.2 137.2 178.4 

### 2000 6 95 100 110 116 123 140 180 7 95 92 100 107 

### 113 128 170 8 101 107 115 118 125 

### 138 185 9 105 103 

### 104 117 126 145 186 

### 10 103 98 98 109 

### 117 133 180 Average 

### 99.8 100 105.4 113.4 120.8 136.8 180.2 

## In both test groups, no mortality was observed. In 2,000 mglkg group, the sluggishness was observed 30 minutes after the administration but it disappeared in 6 hours. Also in 2,000 mglkg group, the body weight gain slowed down in the early stage but it was normal after 

## 14 days. No abnormality was observed in autopsy at the termination.

# ATTACHMENT 4 Ames Test

Cover Sheet
- Not Included in Page Count 

# z/

## Ames Test , Material Safety Test Center 1. Test Method: Plate method based on the methodology published by Ames et al (1975) and Maron et al (1983) and the guideline for mutagenicity test using bacteria from Ministry ofHealth, Labor, and Welfare Japan. 2. Test Substance: 3. Solvent: DMSO 4. Bacteria Strain: Salmonella TAlOO, TA1S3S, TA98, TA1S37 were obtained from Dr. Ames ofUniversity ofCalifornia and WP2uvrA was from National Institute ofHealth Science. Only bacteria ofwhich genetic nature were verified were preserved. Culture ofbacteria grown up to the stationary phase was stored iri small vials at -80 degree C after 8.2% ofOMSO was added. For use in study, it was thawed and seeded to nutrient broth at 1:SOO ratio and was shaken for 10 hours at 37 degree C. S. S9 and S9mix: Rat liver S9 was obtained from Kikkoman. S9mix was prepared by mixing 10% 

## S9, 4mM NADPH, 4mM NADH, SmM G-6-P, 8 mM MgCI2, 33mM KCI, and 100mM sodium phosphate buffer solution (pH7.4). 6. Plate method: For each concentration level, 0.1 ml oftest substance solution was mixed with O.S ml of0.1 M sodium phosphate buffer solution or 0.5 ml ofS9mix and 0.1 ml of bacteria culture (see 4.). 2 ml oftop agar that contains O.OS J.1 

## mollml of histidinelbiotine was mixed into this and the mixture was spread and set on a minimum glucose agar plate. Then the plate was kept upside-down at 37 degree C for 48 hours. At the end ofincubation, the number ofrevertant colonies was counted. Only one plate was used for each concentration level, while 2 plates each were used for the negative(solvent) control and the positive control. 7. Observation ofgrowth inhibition: The presence ofgrowth inhibition toxicity was checked by comparing the number offine amino-acid dependent bacteria colonies in the test plates with the negative(solvent) control. 8. Judging the results: As a basic rule, the results were considered positive when the number ofrevertant colonies increased as the test substance concentration increased and the number ofrevertant colonies was twice as many as that ofthe negative(solvent) control. 9. Conclusion: According to this test, the mutagenicity in bacteria of BEHTA is considered negative.

## Results ofAmes Test Test No: M-02-S201 

## Test Sample: 1 . Lot # 

## Y#.I .. Test Date: 1112612002
- 1112812002 Revartant Colony Count Bacteria Strain TA 100 TA 1535 WP2IM'A TAG8 TA1537 S9Mix No Yes No Yes No Yes No Yes No 

## I Yes Control (OMSO) 

### Count Avg 89 112 103 96 

### 8 15 12 13 34 31 31 29 21 30 22 34 10 14 12 16 101 100 12 13 33 30 

### 22 32 11 15 'Mth Test Sample (dissolved In OOSO)

(mlcrogrammelplate) 0.3 88 99 8 4 25 21 17 20 5 10 1.2 88 88 10 7 27 29 G 

### 20 6 8 4.9 80 115 8 6 18 18 15 20 8 11 

### 20 82 118 5 11 21 34 11 10 4 11 78 95 90 4 7 20 

### 29 11 14 5 7 313 81 87 8 10 24 27 12 15 7 9 1250 81 81 4 8 16 28 21 11 8 10 5000 83 80" 6 7' 19 24' 10 23" 9 5' • Precipitation was noticed
Conclusion Negative Negative Negative Negative Negative Negative Negative Negative Negative Negative Positive Control Substance AF-2 B(a)P NaN3 2-AA Af-2 2-AA AF-2 B(a)P 9-AA B(a)P (mictogrammelplate) 0.01 5 0.5 2 0.01 10 0.1 5 80 5 Count Avg 452 413 1098 1087 375 395 398 367 90 104 479 466 4« 503 333 301 505 514 300 292 433 1093 385 383 97 473 474 317 510 296 AF-2 2-{2.furyl)-3-{5-nitro-2-futyl)aaytamide B(a)P Benzo{a)pyrene NaN3 SocfIUlll azide 2-AA 2-Aminoanthracene 9-AA 9-Aminoaaidide

# ATfACHMENT 

# 5 

# Primary Skin Irritation Study

Cover Sheet
- Not lncluded in Page Count

## Skin Primary Irritation Study in Guinea-pig with Study period: 

## 1112512002 -<1112812002 Report prepared: 1112912002 Facility: Chemical Safety Test Center Saitama Laboratory 25-1, Oh-azakuroiwa, Yoshimi-cho, Hiki-gun, Saitama-ken, Japan Supervisor: Noriko Ohyama 

## I. Summary Skin primary irritation study in guinea-pig was conducted with· fhe test substance was applied for 24 hours to flanks oftest animals using occlusive adhesive. The results ofskin examinations at 3 hours and 48 hours after the adhesive was removed were as follows: Test Substance Appearance Primary Irritation Index Classification 

# BEHTA Liquid 

## 0.5 Mild irritant 

## II. Purpose ofStudy Evaluation ofskin primary irritation in guinea-pig with which was provided by
< 

## ..,td. III. Test Substance and Study Method I. Test Substance: 2. Preparation ofTest Solution: Used without dilution. 3. Test Animal: Hartley white female guinea-pig were purchased from Sankyo 

## Lab Service and were kept in metal cages. They were fed solid feed (RC4: Oriental Yeast Industries) and water freely for 5days prior to the test. Healthy animals, a group of six, with body weight ofapproximately 350 g were selected for study. Animals were kept in a study room at 23 

# ± 2°C, RH 50 

# ± 10%, ventilation
- air replacement rate 17 timeslhour, and with illumination for 12 hours (6:00
- 18:00) a day. 

# 5

## 4. Study Procedures: The flanks oftest animals were shaved with electric hair trimmer and electric shaver. The cloth 

## (2 x 

## 4 cm) ofocclusive patch test adhesive was moistened with 

## 0.2 ml ofthe test substance and was applied to the test spot ofeach animal for 24 hours. Examinations ofthe test spot were made at 3 hours, 24 hours, and 

## 48 hours after the adhesive was removed and the appearance ofthe skin 

## was rated as follows: Erythema formation Edema formation None 

# o 

# o Light 1 1 

## Clear 2 2 

## Medium 3 3 

## Heavy/Scab/Corrosion 4 4 

## Classification: P.I.!. 

## Classification 

# oto less than 0.5 

## Non irritant 0.5 

## to less than 2.0 

## Mild irritant 2.0 

## to less than 5.0 

## Moderate irritant 5.0 

## to less than 6.0 

## Strong irritant 6.0 

## to 8.0 

## Corrosive P.Ll. (Primary Irritation Index) is calculated as follows: P.LI. = 

## the sum oferythema and edema formation ratings (avg. ofsix test animals) after 

## 3 hours and 

## 48 hours ofapplication divided by two. IV. Results The following ratings were obtained. Test Animal 1 2 

### 3 4 

### 5 6 

## Total Average 3 

## hours Erythema Edema 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 48 

## hours Erythema 1 1 1 1 

### 1 1 6 

### 1 

## Edema 0 0 0 0 0 0 0 0 

## Total ofAverage: 1.0 P.I.1. 0.5 

## According to this study, P.LI. of is 0.5 ano is classified mild irritant. Note: Positive control test to validate the reliability ofthe test method is conducted periodically with dodecanoic acid, sodium saIl.

# ATTACHMENT 6 

# Skin Sensitization Study

Cover Sheet Not Included in Page Count 

# ),,7

## Skin Sensitization Study in Guinea-pig with Study period: 111612002
- 17J2712002 Report prepared: 17J2712002 Facility: I _ Ltd. Raw Material Test Center 210 Nakanuma, Minamiashigara-shi, Kanagawa-ken, Japan Test Supervised by: Atsuko Yuasa 

## I. Summary Skin sensitization study in guinea-pig was conducted with based on Cumulative Contact Enhancement Test method. The number ofanimals used for testing 

# was: 4 - preliminary test, 10
- sensitization test group, and 5 - control. 10% ethanol dispersion was used for sensitizing and 1 %,0.3%, and 0.01 % dispersions were used for challenging. The results were as follows: Conc;:entration(%) Solvent Test Group Control Positive (%) Avg. Rating Positive Avg. Rating 1 Ethanol 

# o 0.1 

# o o 0.3 Ethanol 

# o o o o 0.01 Ethanol 

## o 

# o o o



## o Ethanol 

## o 

## o 

# o o According to this study, 's not considered a skin sensitizer.



# n. Purpose ofStudy Evaluation ofskin sensitization in guinea-pig with Ill. Test Substance and Study Method I. Test Substance: . clear colorless liquid) 2. Preparation ofTest Dispersion: Dispersed in ethanol. Preliminary test: 50%, 30%, 10%, 3%, 1 %,0.3% Sensitization: 1 0% Challenging: 1%, 0.3%, 0.01%

## 3. Test Animal: Hartley white female guinea-pigs (Breeder: Nihon Charles River) were purchased from Orientlil Yeast and were kept in metal cages. 6 weeks old animals (body weight: 350
- 400 g) were used for the preliminary test and 3 weeks old animals (body weight: 200
- 250 g) were used for the sensitization test. They were fed solid feed (RC4: Oriental Yeast Industries) and water freely and healthy animals were selected for study. Animals were kept in a study room at 23 

# ± 2 degree C, RH 50 

# ± 10%, ventilation
- air replacement rate 15 timeslhour, and with illumination for 12 hours (7:00
- 19:00) a day. 5. Number ofAnimals Used: 4 - preliminary test, 10
- sensitization test group, and 5 ­ control. 6. Study Procedures: Study was planned and carried out based on Cumulative Contact Enhancement Test method. Preliminary test (group of4): Day -14: Epidennal injection of 0.1 ml each ofFreund's Complete Adjuvant (FCA) was made to two spots ofthe lower back ofthe preliminary test group animals. Day -7: 0.1 ml ofeach preliminary test dispersion was applied for 24 hours using occlusive adhesive to the 

## flank of FCA treated (see above) animals. Examinations ofthe skin was made up until 48 hours after the removal of adhesive to detennine the concentration range for the sensitization test. Sensitization (group of 10) Day 0: First sensitization. 2 x 4 cm of lint cloth was moistened with 0.2 ml of50% test substance dispersion and was applied for 24 hours to the lower back of test animals by occlusive adhesive. Day 2: Second sensitization. The same application as the first. Day 7: Third sensitization. The same application as the first after 0.1 ml each of FCA was injected at two spots in the test area. Day 9: Fourth sensitization: The same application as the first. Challenging: Day 21: 0.1 ml ofeach test dispersion was applied for 24 hours to the flank ofanimals by occlusive adhesive. Examination: Day 22: 3 hours after the adhesive was removed. Day 23: 24 hours after the adhesive was removed.

## Day 24: 48 hours after the adhesive was removed. 7. Rating ofSkin Reaction 0; No reaction 1: Light erythema 2: Clear erythema 3: Heavy erythemalEdema 4. Blister/Scab 8. Classification is based on positive reaction ratio and rating. Rating Positive Ratio 0-1.0 1.0 - 2.0 2.0 - 3.0 0-200.4 

### A B 20 - 500.4 B B C 50 - 800.4 C 

# o

80%- C 

# o

A: Very mild B: Mild C: Moderate 0: Strong E: Severe 

## IV. Results Table 1 Examination Results: Preliminary test - Primary skin irritation (n=4) 3 hours after removal. 24 hours after removal. 48 hours after removal. Cone. % 50 30 10 3 0.3 50 30 10 3 0.3 50 30 10 3 Rating 1 1 1 2 4 4 4 0 0 2 3 4 4 0 0 2 3 2 3 3 2 0 0 0 2 1 2 1 0 0 2 1 2 1 3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 0 0 0 0 0 0 2 3 0 0 0 0 2 3 0 0 5 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 

## Table 2 Examination Results: Sensitization Test Group (n=lO) 3hrs 24 hrs 48 hrs after after after remova remova remova I I I 1°,.{, 0.30.4 0.010.4 10.4 0.30.4 0.010.4 10.4 0.3% Rating 0 9 10 10 10 10 10 10 10 1 1 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 3 0 0 0 0 0 0 0 0 4 0 0 0 0 0 0 0 0 Positive Over ratio(0.4) rating 1 10 0 0 0 0 0 0 0 Over rating 2 0 0 0 0 0 0 0 0 Avg rating 0.1 0 0 0 0 0 0 0 >3.0 

# o E

4

0 0 0 0 0.3 4 0 0 0 0

0.01%

10 0 0 0 0 0 0 0 

# 30

## Table 3 Examination Results : Control Group (n=5) 3hrs 24 hrs 48 hrs after after after remova remova remova I I I 1% 0.3% 0.01% 1% 0.3% 0.01% 1% 0.3% 0.01% Rating 0 4 4 4 4 4 4 4 4 4 

# .. 1 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 3 0 0 0 0 

### 0 0 0 0 0 4 0 0 0 0 0 0 0 0 0 Positive Over ratio(%) rating 1 0 0 0 0 0 0 0 0 0 Over rating 2 0 0 0 0 0 0 0 0 0 Avg rating 

### 0 0 0 0 0 

### 0 0 0 0**~** 

## According to this study
-**~s** 

## not considered a skin sensitizer. No unusual behavior ortest animals was observed uring the test period.



# ..3/

# ATfACHMENT7 CAS Expert Inventory Service

Cover Sheet Not Included in Page Count 

# 32

# em Inventory 

# Expert

# Service
A division of the American Chemical Society Phone; 

### 8OQ..631·1884. 614.-447-3600 (ext. 2308) 

## Fax: 614-447.3747 

### E-man: answers@cas.org



## INVENTORY EXPERT SERVICE REPORT
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## Registered
CA INDEX NAME

Please print the above CA Index Name on the appropriate page of your PMN. 

# o If this box is checked, CAS has made correction(s) marked in red to your IES order. Please make the same correction(s) to your PMN before submitting it to the EPA.

Columbus_ Oh.o 13210-01)1;,­ ,-.:... J

/ .



# IUPAC NAME CAS No .

. -- -- ___ .1 "'7nn"'7n 

## 1\' 

# CA INDEX NAME

., 

# .. . 

## .,

# A1TACHMENT 8 

# Infrared Spectra

Cover Sheet Not Included in Page Count 

# 3S

## 100 

# 95 90 85 .: 

## 80
­ ..

i.i J**~ ~**  -' 

## 75
- 70
­

# ~ IF! 

## 65­ 

## 60 55 

## 50 -'­ 45
-­ 40 =/



## 4000 

## , i 

## 3500 3000 2500 2000 Wavenumbers (cm-1) 

## 1500 1000 500 8 

# 11: Thu Nov 21 10:46:22 

## 2002 ;q-,,/: 

## 64 

# 2002, 

# 11.2 

# I

# (~.)**~fur** 

# t<aJ:j}**r~t, 5J'~~~:**  

## 4.000

# ATf ACHMENT 9 

# H-NMR Spectra

Cover Sheet Not Included in Page Count 

# 37co.



# 37

# BllJ~dS 

# J'1dH 01LN3WHJVLLV

## 3 F 6**~ta** 

## (NEt3**,AcOH~)** 

## PUMP : LC-IOATVP SYSTEM CONTROLER: SCL-IOA VP DETECTER : SPD-IOAVVP AUTO INJECTER : SIL-IOAD VP CHROMATOPAC: 6400 DX2 sample size '0.01mg/10ml column : Tsk-gel ODS -80TS 03120 column size : 4.6 X 

## 150mm flow rate :**l~lImin** 

## pressure : kg{ detector : 254nm range : Aux eluent A H20 ; 0.05%AcOH/0.2%Et3N BTHF/cl"h<:N 

# = 7/3 ; 0.05%AcOH/0.2%Et3N 

# " B /,4 ::**~O** / 

# <.0