SAT Report

PMN Number: P-10-0476

SAT Date: 8/10/2010

Print Date: 5/2/2011

Related cases: CBI: Yes

Health related cases: 

Ecotox related cases: No reasonable analogs were found.

Concern levels:

Type of Concern: Health Eco Comments

Level of Concern: 1-2 1

 Persistence Bioaccum Toxicity Comments

3 11

Exposure Based Review:

Health: Yes Exposure based testing (health): Inhalation only

Ecotox: No

Routes of exposure: Health: Inhalation 

Ecotox: No releases to water

Fate: ;

Keywords:

 Keywords: LUNG

Summary of Assessment:

 Fate:

Fate Summary: P-10-0476

FATE: 

Solid 

S = Negl.

VP < 1.0E-6 torr at 25 C (E)

BP > 400 C (E)

H < 1.00E-8 (E)

POTW removal (%) = 90 via sorption; OECD 111 (Hydrolysis): t1/2(pH1.2,4,7,9): 0.08 +/-

 0.06%/5d; OECD311(AnaerobicBiodeg): 0%/62d.

Time for complete ultimate aerobic biodeg > mo

Sorption to soils/sediments = v.strong
PBT Potential: P3B1

*CEB FATE: Migration to ground water = negl

 Health:

 Health Summary: Absorption is nil all routes based on physical/chemical 

properties. Here is concern for lung effects from lung overload if respirable particles are inhaled 

based on the high molecular weight of the PMN material ( . Low moderate 

concern.

 Test Data: inconclusive negative in Salmonella and E coli, test was 

conducted with activation only

inconclusive negative for chromosome aberrations in rat lymphocytes, not explanation of dose 

selection was provided

combined repeated dose/developmental/reproductive study in rats (100, 300, 1000 mg/kg) - no 

effects seen, NOEL = 1000 mg/k

not a dermal sensitizer in guinea pigs, guinea pig maximization test

eye irritant in rabbits, effects cleared by 72 hours

acute oral study in rats - no deaths or signs of toxicity at 2000 mg/kg

mild skin irritant in rabbits, cleared by 24 hours

acute oral study in mice, multiple results reported - Ld50 values were either greater than 5000 

mg/kg or between 500 and 5000 mg/kg

 Ecotox:

Test 

Organism

Test 

Type

Test End 

Point

Predicted Measured Comments

fish 96-h LC50 *

daphnid 48-h LC50 * *

green algal 96-h EC50 *

fish _ chronic value *

daphnid _ chronic value *

algal _ chronic value *

Sewage Sludge 3-h EC50 _

Sewage Sludge _ Chronic Value _

Ecotox Values Comments: Predictions are based on SARs for nonionic polymers; SAR 

chemical class = polymer-nonionic-insoluble; 

solid with mp unk; S < 0.001 mg/L at 25 C (P); pH7; effective concentrations based on 100% 

active ingredients and nominal concentrations; hardness <150.0 mg/L as CaCO3; and TOC 

<2.0 mg/L;

A single acute daphnia study accompanied the submission. This study complied with OPPTS 

and OECD guidelines for: 1) O2, pH, temperature, water hardness values and other water quality 

parameters; 2) species, age, number of organisms per replicate, and biomass loading rates; and, 

3) replicate and overall variability. Because of the very low water solubility of the PMN, only 

one nominal loading rate concentration (1,000 mg/L) was tested. This limit test was essentially 
an assay of the water accommodated fraction (WAF). No attempt was made to measure the 

concentration of the PMN analytically. Results indicated no mortalities or effects on behavior in 

the treatment groups consistent with No Effects at Saturation as predicted by ECOSAR.

Factors Values Comments

Assessment Factor 10

Concentration of Concern 

(ppb)

*

SARs nonionic polymers

SAR Class polymer-nonionic-brominated 

hydrocarbon

Ecotox Factors Comments: 

 SAT Chair: Becky Jones