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                                                                   EXHIBIT 10.14

                                SECOND AMENDMENT
                     TO 7000 BROADWAY BUILDING OFFICE LEASE
                                    between
                        DENVER JACK LIMITED PARTNERSHIP
                                      and
                ALLOS THERAPEUTICS, INC., A Virginia Corporation
                               Dated June 7, 1996

THIS SECOND AMENDMENT is to that certain office lease (the "Lease") dated
October 30, 1995 and First Amendment to 7000 Broadway Building Office Lease
dated October 30, 1995, by and between Denver Jack Limited Partnership
("Lessor") and Allos Therapeutics, Inc., a Virginia Corporation ("Lessee") with
respect to approximately 4,022 square feet of space on the 3rd floor, known as
Suite 310 (the "Premises"), in the building known as 7000 Broadway, Denver,
Colorado (the "Building"). In the event of any conflict between the terms and
provisions of the Lease as amended by the First Amendment, and the terms and
provisions of this Second Amendment, the terms and provisions of this Second
Amendment shall control.

     1. Amendment to Article 34, Rider Number One of the Lease Document. Lessor
        and Lessee do hereby agree that effective June 12, 1996 (the "Effective
        Date") the description of the Premises shall be deemed to be amended to
        include approximately 2,308 rentable square feet of additional office
        space located on the third (3rd) floor known as Suite 320 (the
        "Expansion Space") as outlined on the diagram of the third (3rd) floor
        of the building, attached hereto as Exhibit "A".

        Tenant's right to occupy and obligation to pay Base Rent on the
        "Expansion Space" shall commence on the "Effective Date" and shall
        terminate with the lease term which is redefined in paragraph 2 of this
        Second Amendment.

        Except as otherwise specifically provided herein, as of the "Effective
        Date" any reference to the term "Premises" in the Lease or any
        amendments thereto, including this Amendment, shall be deemed to include
        the "Expansion Space" as though originally a part of the Premises under
        the Lease and Tenant's occupancy thereof shall be subject to all of the
        terms and conditions of the Lease.

     2. Amendment to Article 1 of the Lease Document. Lessor and Lessee do
        hereby agree that as of the "Effective Date", the lease term as
        described in Article 1 of the Lease shall be extended through June 30,
        2001.

     3. Amendment to Article 35 of Rider Number One to the Lease document. As of
        the "Effective Date", Lessor and Lessee do hereby agree that the Rent
        obligation in Article 35 of Rider Number One to the lease document be
        amended as outlined below:

                  06/12/96 - 12/31/96:    $6,215.16 per month
                  01/01/97 - 12/31/98:    $6,382.75 per month
                  01/01/99 - 06/30/01:    $6,550.33 per month

        Such other charges as may be required by the terms of this Lease to be
        paid by Lessee may be referred to in the Lease document as "Additional
        Rent." Lessor shall have the same rights as to the Additional Rent as it
        has to the payment of the rent set forth above.

        All payments are due on or before the first day of the first full
        calendar month of the term hereof and a like sum on or before the first
        day of each and every successive calendar month thereafter during the
        term hereof. Rent for any period during the term hereof, which is less
        than one month, shall be prorated based on a thirty (30) day calendar
        month. All rents payable hereunder shall be paid to Lessor in lawful
        money of the United States of America constituting legal tender at the
        time of payment, at the office of the building or to such other person
        at such other place as Lessor may, from time to time, designate in
        writing. The current payments or notice to Lessor shall be c/o CB
        Commercial Real Estate Group, Inc., 1050 Seventeenth Street, Suite 800,
        Denver, Colorado 80265.
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     4. Tenant Improvements. Lessee shall take the "Expansion Space" in its
        "as-is" condition.

     5. Amendment to Article 39 of Rider Number One to the Lease Document. As of
        the Effective Date, Tenant shall have the right to use on an unassigned,
        unreserved basis, an additional eleven (11) parking spaces in the 7000
        Broadway parking area free of charge the term of the Lease. These spaces
        will be in addition to the twenty (20) parking spaces under Lessee's
        control in the Lease document.

     6. Amendment to Article 38 of Rider Number One of the Lease Document.
        Lessee's percentage of Operating Expenses as of the "Effective Date"
        shall be that proportion which the rentable area leased bears to the
        rentable area of the building. For purposes of the Lease, as herein
        amended, such percentage is 13.94%.

     7. Conflicts. If there is any conflict between the terms and provisions of
        this First Amendment and the terms and provisions of the Lease, the
        terms and provisions of this First Amendment shall govern. Except as
        herein specifically set forth, all other provisions of the Lease shall
        remain in full force and effect and be binding upon the parties in
        accordance with their terms.

LANDLORD:

          DENVER JACK LIMITED PARTNERSHIP
          CB COMMERCIAL REAL ESTATE GROUP, INC.
          AS MANAGER


     By:  /s/ ILLEGIBLE
          -------------------------------------
     Its: Senior Vice President
          -------------------------------------
     By:  /s/ ILLEGIBLE
          -------------------------------------
     Its: Assistant Vice President
          -------------------------------------


TENANT:

          ALLOS THERAPEUTICS,
          A VIRGINIA CORPORATION

     By:  /s/ JOHN T. GREFF
          -------------------------------------
     Its: VP Finance & CFO
          -------------------------------------


STATE OF COLORADO

COUNTY OF ADAMS

The foregoing instrument was acknowledged before me this 17th day of June, 1996
by John T. Guff as VP Finance and CFO.

Witness my hand and official seal.

My commission expires: May 2, 1999

                                             /s/ Lisa D. Lange
                                             -------------------------------
                                             Notary Public

[SEAL]
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                                 7000 BROADWAY
                                    BUILDING




                          McDERMOTT PLANNING & DESIGN








                                  EXHIBIT "A"
                                  FLOOR PLAN







                               ALLOS THERAPEUTICS
                             THIRD FLOOR SPACE PLAN