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Submission Report

Submission Information

Submission ID : 25349542 Submission Name : 2H-3,1-Benzoxazine-2,41H-dione

AR Number : 

Chemical Information

CAS Number : 118-48-9 Ninth Collective Index Name : 2H-3,1-Benzoxazine-2,4(1H)-dione

Submitter Information

Submitter's Name : EPA

Address : 

City : Washington

State : DC

ZIP/Postal Code: 

Country: 

Type of Submitter : Company

Technical Point of Contact Information

Technical Point of Contact : 

Title : 

Phone Number : 

Fax Number : 

E-Mail Address : 

Additional Technical Point of Contact Information

Technical Point of Contact : 

Title : 

Phone Number : 

Fax Number : 

E-Mail Address : 

Sponsor Information

Sponsor's Name : EPA

Address : 

City : 

State : 

ZIP/Postal Code : 

Country : 

Phone Number : 

Fax Number : 
High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

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E-Mail Address : 

Type of Sponsor : Company

Technical Point of Contact Information

Technical Point of Contact : 

Title : 

Phone Number : 

Fax Number : 

E-Mail Address : 

 Acute Toxicity to Aquatic Vertebrates

CAS Number : 118-48-9

Sponsored

Chemical Name :

2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance - Acute Toxicity To Aquatic Vertebrates

Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance

Purity/Composition

and Other Test

Substance

Comments:

None

Sponsored

Chemical Result

Type:

Measured

Test Substance

Result Type:

Measured

Method - Acute Toxicity To Aquatic Vertebrates

Year Study

Performed:

1982

Method/Guideline

Followed:

Other

Other

Method/Guideline:

DIN 38412, Teil 15

Deviations from

Method/Guideline:

No Data

Species: Leuciscus idus

GLP: No

Analytical

Monitoring:

Yes

Test Type: Static

Test Vessel: No Data

Water Media Type: Freshwater

Test

Concentrations:

No Data

Nominal and

Measured

Concentrations:

Exposure Period: 96 Hours
High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint[6/15/2011 10:42:13 AM]

Vehicle Used: No Data

Vehicle Name: No Data

Vehicle Amount

and Units:

Alkalinity:

Dissolved Oxygen:

pH Value:

Test Temperature

and Units:

Photo

(Light/Dark):

Salinity:

TOC:

Water Hardness:

Method/Guideline

Test Conditions

Remarks:

Method/guideline followed: Bestimmung der Wirkung von Wasserinhaltsstoffen suf Fische,

DIN 38412, Teil 

15 

Limit Test: Unknown

Test Results - Acute Toxicity To Aquatic Vertebrates

NOEC Exposure

Duration:

96 Hours

NOEC: = 22 mg/L Unknown

LOEC Exposure

Duration:

LOEC:

NOELR Exposure

Duration:

NOELR:

LOELR Exposure

Duration:

LOELR:

LC/EC Mean Value : Exposure

Duration

Exposure

Units

LC/EC % Value

Description

Mean

Value

or

Lower

Mean

Value

Upper

Mean

Value

Units Effect

Observed

Basis for

Concentration

96 Hours LC 50 % = 46 100 mg/L Mortality Unknown
High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

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Results Remarks:

Reliability/Data Quality - Acute Toxicity To Aquatic Vertebrates

Reliability: 3 - Not Valid

Reliability

Remarks:

Key Study Sponsor

Indicator:

Reference - Acute Toxicity To Aquatic Vertebrates

Reference: IUCLID dataset

 Acute Toxicity to Aquatic Invertebrates

CAS Number : 118-48-9

Sponsored

Chemical Name :

2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance - Acute Toxicity To Aquatic Invertebrates

Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance

Purity/Composition

and Other Test

Substance

Comments:

None

Sponsored

Chemical Result

Type:

Measured

Test Substance

Result Type:

Nominal

Method - Acute Toxicity To Aquatic Invertebrates

Year Study

Performed:

1988

Method/Guideline

Followed:

EU C.2 (84/449/EEC)

Other

Method/Guideline:

Deviations from

Method/Guideline:

No Data

Species/In Vitro

System:

Daphnia magna

GLP: No

Analytical

Monitoring:

No

Test Type: Static

Test Vessel: No Data
High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint[6/15/2011 10:42:13 AM]

Water Media Type: Freshwater

Test

Concentrations:

No Data

Nominal and

Measured

Concentrations:

Exposure Period: 48 Hours

Vehicle Used:

Vehicle Name:

Vehicle Amount

and Units:

Alkalinity:

Dissolved Oxygen:

pH Value:

Test Temperature

and Units:

Photo

(Light/Dark):

Salinity:

TOC:

Water Hardness:

Method/Guideline

Test Conditions

Remarks:

Limit Test:

Test Results - Acute Toxicity To Aquatic Invertebrates

NOEC Exposure

Duration:

NOEC:

LOEC Exposure

Duration:

LOEC:

NOELR Exposure

Duration:

NOELR:

LOELR Exposure

Duration:

LOELR:

LC/EC Mean Value : Exposure

Duration

Exposure

Units

LC/EC % Value

Description

Mean

Value

or

Upper

Mean

Value

Units Effect

Observed

Basis for

Concentration
High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint[6/15/2011 10:42:13 AM]

Lower

Mean

Value

48 Hours EC 50 % = 86 mg/L Mortality Unknown

48 Hours EC 100 % = 125 mg/L Mortality Unknown

48 Hours EC 0 % = 62.5 mg/L Mortality Unknown

Results Remarks:

Reliability/Data Quality - Acute Toxicity To Aquatic Invertebrates

Reliability: 2 - Valid With Restrictions

Reliability

Remarks:

Key Study Sponsor

Indicator:

Reference - Acute Toxicity To Aquatic Invertebrates

Reference: IUCLID dataset

 Acute Toxicity to Aquatic Invertebrates

CAS Number : 118-48-9

Sponsored

Chemical Name :

2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance - Acute Toxicity To Aquatic Invertebrates

Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance

Purity/Composition

and Other Test

Substance

Comments:

None

Sponsored

Chemical Result

Type:

Measured

Test Substance

Result Type:

Nominal

Method - Acute Toxicity To Aquatic Invertebrates

Year Study

Performed:

1988

Method/Guideline

Followed:

EU C.2 (84/449/EEC)

Other

Method/Guideline:

Deviations from

Method/Guideline:

No Data

Species/In Vitro

System:

Daphnia magna
High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint[6/15/2011 10:42:13 AM]

GLP: No

Analytical

Monitoring:

No

Test Type: Static

Test Vessel: No Data

Water Media Type: Freshwater

Test

Concentrations:

No Data

Nominal and

Measured

Concentrations:

Exposure Period: 24 Hours

Vehicle Used:

Vehicle Name:

Vehicle Amount

and Units:

Alkalinity:

Dissolved Oxygen:

pH Value:

Test Temperature

and Units:

Photo

(Light/Dark):

Salinity:

TOC:

Water Hardness:

Method/Guideline

Test Conditions

Remarks:

Limit Test:

Test Results - Acute Toxicity To Aquatic Invertebrates

NOEC Exposure

Duration:

NOEC:

LOEC Exposure

Duration:

LOEC:

NOELR Exposure

Duration:

NOELR:
High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint[6/15/2011 10:42:13 AM]

LOELR Exposure

Duration:

LOELR:

LC/EC Mean Value : Exposure

Duration

Exposure

Units

LC/EC % Value

Description

Mean

Value

or

Lower

Mean

Value

Upper

Mean

Value

Units Effect

Observed

Basis for

Concentration

24 Hours EC 50 % = 110 mg/L Mortality Unknown

24 Hours EC 100 % = 250 mg/L Mortality Unknown

Results Remarks:

Reliability/Data Quality - Acute Toxicity To Aquatic Invertebrates

Reliability: 2 - Valid With Restrictions

Reliability

Remarks:

Key Study Sponsor

Indicator:

Reference - Acute Toxicity To Aquatic Invertebrates

Reference: IUCLID dataset

 Acute Toxicity to Aquatic Plants

CAS Number : 118-48-9

Sponsored

Chemical Name :

2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance - Acute Toxicity To Aquatic Plants

Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance

Purity/Composition

and Other Test

Substance

Comments:

Sponsored

Chemical Result

Type:

Measured

Test Substance

Result Type:

Nominal

Method - Acute Toxicity To Aquatic Plants

Year Study

Performed:

1988
High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint[6/15/2011 10:42:13 AM]

Method/Guideline

Followed:

Other

Other

Method/Guideline:

Scenedesmus-Zellvermehrungs-Hemmtest, DIN 38412 Teil 9, Bestimmung der

Hemmwirkung von Wasserinhaltsstoffen auf Gruenalgen

Deviations from

Method/Guideline:

No Data

Species: Scenedesmus subspicatus

GLP: No

Analytical

Monitoring:

No

Test Type: Static

Test Vessel: No Data

Water Media Type: Freshwater

Test

Concentrations:

Nominal and

Measured

Concentrations:

Exposure Period: 72 Hours

Vehicle Used:

Vehicle Name:

Vehicle Amount

and Units:

Alkalinity:

Dissolved Oxygen:

pH Value:

Test Temperature

and Units:

Photo

(Light/Dark):

Salinity:

TOC:

Water Hardness:

Method/Guideline

Test Conditions

Remarks:

Limit Test:

Test Results - Acute Toxicity To Aquatic Plants

NOEC Exposure

Duration:
High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint[6/15/2011 10:42:13 AM]

NOEC:

LOEC Exposure

Duration:

LOEC:

NOELR Exposure

Duration:

NOELR:

LOELR Exposure

Duration:

LOELR:

Effect : Exposure

Duration

Exposure

Units

Type % Value

Description

Mean

Value

or

Lower

Mean

Value

Upper

Mean

Value

Units Basis

for

Effect

Basis for

Concentration

72 Hours EC 50 % = 14.5 mg/L No

Data

Unknown

72 Hours EC 90 % = 34.9 mg/L No

Data

Unknown

72 Hours EC 10 % = 5 mg/L No

Data

Unknown

Results Remarks:

Reliability/Data Quality - Acute Toxicity To Aquatic Plants

Reliability: 3 - Not Valid

Reliability

Remarks:

Key Study Sponsor

Indicator:

Reference - Acute Toxicity To Aquatic Plants

Reference: IUCLID dataset

 Acute Toxicity to Aquatic Plants

CAS Number : 118-48-9

Sponsored

Chemical Name :

2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance - Acute Toxicity To Aquatic Plants

Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance

Purity/Composition

and Other Test

Substance

Comments:
High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint[6/15/2011 10:42:13 AM]

Sponsored

Chemical Result

Type:

Measured

Test Substance

Result Type:

Nominal

Method - Acute Toxicity To Aquatic Plants

Year Study

Performed:

1988

Method/Guideline

Followed:

Other

Other

Method/Guideline:

Scenedesmus-Zellvermehrungs-Hemmtest, DIN 38412 Teil 9, Bestimmung der

Hemmwirkung von Wasserinhaltsstoffen auf Gruenalgen

Deviations from

Method/Guideline:

No Data

Species: Scenedesmus subspicatus

GLP: No

Analytical

Monitoring:

No

Test Type: Static

Test Vessel: No Data

Water Media Type: Freshwater

Test

Concentrations:

Nominal and

Measured

Concentrations:

Exposure Period: 96 Hours

Vehicle Used:

Vehicle Name:

Vehicle Amount

and Units:

Alkalinity:

Dissolved Oxygen:

pH Value:

Test Temperature

and Units:

Photo

(Light/Dark):

Salinity:

TOC:

Water Hardness:
High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint[6/15/2011 10:42:13 AM]

Method/Guideline

Test Conditions

Remarks:

Limit Test:

Test Results - Acute Toxicity To Aquatic Plants

NOEC Exposure

Duration:

NOEC:

LOEC Exposure

Duration:

LOEC:

NOELR Exposure

Duration:

NOELR:

LOELR Exposure

Duration:

LOELR:

Effect : Exposure

Duration

Exposure

Units

Type % Value

Description

Mean

Value

or

Lower

Mean

Value

Upper

Mean

Value

Units Basis

for

Effect

Basis for

Concentration

96 Hours EC 50 % = 16 mg/L No

Data

Unknown

96 Hours EC 90 % = 36.9 mg/L No

Data

Unknown

96 Hours EC 10 % = 4.5 mg/L No

Data

Unknown

Results Remarks:

Reliability/Data Quality - Acute Toxicity To Aquatic Plants

Reliability: 3 - Not Valid

Reliability

Remarks:

Key Study Sponsor

Indicator:

Reference - Acute Toxicity To Aquatic Plants

Reference: IUCLID dataset

 Acute Toxicity

CAS Number : 118-48-9
High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint[6/15/2011 10:42:13 AM]

Sponsored Chemical Name

:

2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance - Acute Toxicity

Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance

Purity/Composition

and Other Test Substance

Comments:

Sponsored Chemical Result

Type:

Measured

Method - Acute Toxicity

Route of Administration: Oral

Type of Exposure: No Data

Species: Guinea pig

Mammalian Strain: No Data

Gender:

Number of Animals per

Dose:

Dose:

Year Study Performed:

Method/Guideline

Followed:

Other

GLP:

Method/Guideline and

Test Condition Remarks:

Test Results - Acute Toxicity

Concentration (LC/LD) : LC/LD % Value

Description

Value/Lower

Concentration

Upper

Concentration

Units

LD 50 % circa 500 mg/kgbw

Number of Deaths ( Male

):

Number of Deaths ( Female

):

Number of Deaths ( Total

):

Results Remarks:

Conclusion:
High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint[6/15/2011 10:42:13 AM]

Reliability/Data Quality - Acute Toxicity

Reliability: 3 - Not Valid

Reliability Remarks: Summary is in German

Key Study Sponsor

Indicator:

Reference - Acute Toxicity

Reference: IUCLID dataset

 Acute Toxicity

CAS Number : 118-48-9

Sponsored Chemical Name

:

2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance - Acute Toxicity

Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance

Purity/Composition

and Other Test Substance

Comments:

Sponsored Chemical Result

Type:

Measured

Method - Acute Toxicity

Route of Administration: Inhalation

Type of Exposure: No Data

Species: Rat

Mammalian Strain: No Data

Gender:

Number of Animals per

Dose:

Concentration:

Year Study Performed:

Method/Guideline

Followed:

Other

GLP:

Method/Guideline and

Test Condition Remarks:

exposure duration: 1 hour

Test Results - Acute Toxicity

Concentration (LC/LD) : LC/LD % Value Value/Lower Upper Units
High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint[6/15/2011 10:42:13 AM]

Description Concentration Concentration

LC 50 % = 192 mg/L

Number of Deaths ( Male

):

Number of Deaths ( Female

):

Number of Deaths ( Total

):

Results Remarks:

Conclusion:

Reliability/Data Quality - Acute Toxicity

Reliability: 3 - Not Valid

Reliability Remarks:

Key Study Sponsor

Indicator:

Reference - Acute Toxicity

Reference: IUCLID dataset

 Acute Toxicity

CAS Number : 118-48-9

Sponsored Chemical Name

:

2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance - Acute Toxicity

Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance

Purity/Composition

and Other Test Substance

Comments:

Sponsored Chemical Result

Type:

Measured

Method - Acute Toxicity

Route of Administration: Inhalation

Type of Exposure: Aerosol

Species: Mouse
High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint[6/15/2011 10:42:13 AM]

Mammalian Strain: No Data

Gender:

Number of Animals per

Dose:

Concentration:

Year Study Performed: 1963

Method/Guideline

Followed:

Other

GLP: No Data

Method/Guideline and

Test Condition Remarks:

exposure duration: 4 hours

method: dynamische Inhalation nach Niessen et al.: Arch.

Toxicol. 20, 44 

Test Results - Acute Toxicity

Concentration (LC/LD) : LC/LD % Value

Description

Value/Lower

Concentration

Upper

Concentration

Units

LC 50 % > 0.378 mg/L

Number of Deaths ( Male

):

Number of Deaths ( Female

):

Number of Deaths ( Total

):

Results Remarks:

Conclusion:

Reliability/Data Quality - Acute Toxicity

Reliability: 3 - Not Valid

Reliability Remarks: Summary is in German

Key Study Sponsor

Indicator:

Reference - Acute Toxicity

Reference: IUCLID dataset

 Acute Toxicity

CAS Number : 118-48-9
High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint[6/15/2011 10:42:13 AM]

Sponsored Chemical Name

:

2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance - Acute Toxicity

Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance

Purity/Composition

and Other Test Substance

Comments:

Sponsored Chemical Result

Type:

Measured

Method - Acute Toxicity

Route of Administration: Oral

Type of Exposure: No Data

Species: Rat

Mammalian Strain: No Data

Gender:

Number of Animals per

Dose:

Dose:

Year Study Performed:

Method/Guideline

Followed:

GLP:

Method/Guideline and

Test Condition Remarks:

Test Results - Acute Toxicity

Concentration (LC/LD) : LC/LD % Value

Description

Value/Lower

Concentration

Upper

Concentration

Units

LD 50 % > 5000 mg/kgbw

Number of Deaths ( Male

):

Number of Deaths ( Female

):

Number of Deaths ( Total

):

Results Remarks:
High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint[6/15/2011 10:42:13 AM]

Conclusion:

Reliability/Data Quality - Acute Toxicity

Reliability: 3 - Not Valid

Reliability Remarks:

Key Study Sponsor

Indicator:

Reference - Acute Toxicity

Reference: IUCLID dataset

 Acute Toxicity

CAS Number : 118-48-9

Sponsored Chemical Name

:

2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance - Acute Toxicity

Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance

Purity/Composition

and Other Test Substance

Comments:

Sponsored Chemical Result

Type:

Measured

Method - Acute Toxicity

Route of Administration: Inhalation

Type of Exposure: No Data

Species: Rat

Mammalian Strain: No Data

Gender:

Number of Animals per

Dose:

Concentration:

Year Study Performed:

Method/Guideline

Followed:

Other

GLP: No Data

Method/Guideline and

Test Condition Remarks:

exposure duration: 8 hours

method: BASF Test

Test Results - Acute Toxicity
High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint[6/15/2011 10:42:13 AM]

Concentration (LC/LD) : LC/LD % Value

Description

Value/Lower

Concentration

Upper

Concentration

Units

Number of Deaths ( Male

):

Number of Deaths ( Female

):

Number of Deaths ( Total

):

Results Remarks:

Conclusion:

Reliability/Data Quality - Acute Toxicity

Reliability: 3 - Not Valid

Reliability Remarks: Summary is in German

Key Study Sponsor

Indicator:

Reference - Acute Toxicity

Reference: IUCLID dataset

 Acute Toxicity

CAS Number : 118-48-9

Sponsored Chemical Name

:

2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance - Acute Toxicity

Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance

Purity/Composition

and Other Test Substance

Comments:

Sponsored Chemical Result

Type:

Measured

Method - Acute Toxicity

Route of Administration: Oral

Type of Exposure: No Data

Species: Rat
High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint[6/15/2011 10:42:13 AM]

Mammalian Strain: No Data

Gender:

Number of Animals per

Dose:

Dose:

Year Study Performed:

Method/Guideline

Followed:

Other

GLP:

Method/Guideline and

Test Condition Remarks:

Test Results - Acute Toxicity

Concentration (LC/LD) : LC/LD % Value

Description

Value/Lower

Concentration

Upper

Concentration

Units

LD 50 % > 2500 mg/kgbw

Number of Deaths ( Male

):

Number of Deaths ( Female

):

Number of Deaths ( Total

):

Results Remarks:

Conclusion:

Reliability/Data Quality - Acute Toxicity

Reliability: 3 - Not Valid

Reliability Remarks: Summary is in German.

Key Study Sponsor

Indicator:

Reference - Acute Toxicity

Reference: IUCLID dataset

 Acute Toxicity

CAS Number : 118-48-9
High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint[6/15/2011 10:42:13 AM]

Sponsored Chemical Name

:

2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance - Acute Toxicity

Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance

Purity/Composition

and Other Test Substance

Comments:

Sponsored Chemical Result

Type:

Measured

Method - Acute Toxicity

Route of Administration: Oral

Type of Exposure: No Data

Species: Cat

Mammalian Strain: No Data

Gender:

Number of Animals per

Dose:

Dose:

Year Study Performed:

Method/Guideline

Followed:

Other

GLP:

Method/Guideline and

Test Condition Remarks:

Test Results - Acute Toxicity

Concentration (LC/LD) : LC/LD % Value

Description

Value/Lower

Concentration

Upper

Concentration

Units

LD 50 % > 500 mg/kgbw

Number of Deaths ( Male

):

Number of Deaths ( Female

):

Number of Deaths ( Total

):

Results Remarks:
High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint[6/15/2011 10:42:13 AM]

Conclusion:

Reliability/Data Quality - Acute Toxicity

Reliability: 3 - Not Valid

Reliability Remarks: Summary is in German

Key Study Sponsor

Indicator:

Reference - Acute Toxicity

Reference: IUCLID dataset

 Acute Toxicity

CAS Number : 118-48-9

Sponsored Chemical Name

:

2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance - Acute Toxicity

Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance

Purity/Composition

and Other Test Substance

Comments:

Sponsored Chemical Result

Type:

Measured

Method - Acute Toxicity

Route of Administration: Oral

Type of Exposure: No Data

Species: Mouse

Mammalian Strain: No Data

Gender:

Number of Animals per

Dose:

Dose:

Year Study Performed:

Method/Guideline

Followed:

Other

GLP:

Method/Guideline and

Test Condition Remarks:

Test Results - Acute Toxicity
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Concentration (LC/LD) : LC/LD % Value

Description

Value/Lower

Concentration

Upper

Concentration

Units

LD 50 % = 250 mg/kgbw

Number of Deaths ( Male

):

Number of Deaths ( Female

):

Number of Deaths ( Total

):

Results Remarks:

Conclusion:

Reliability/Data Quality - Acute Toxicity

Reliability: 3 - Not Valid

Reliability Remarks:

Key Study Sponsor

Indicator:

Reference - Acute Toxicity

Reference: IUCLID dataset

 Acute Toxicity

CAS Number : 118-48-9

Sponsored Chemical Name

:

2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance - Acute Toxicity

Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance

Purity/Composition

and Other Test Substance

Comments:

Sponsored Chemical Result

Type:

Measured

Method - Acute Toxicity

Route of Administration: Dermal

Type of Exposure: No Data

Species: Rabbit
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Mammalian Strain: No Data

Gender:

Number of Animals per

Dose:

Dose:

Year Study Performed:

Method/Guideline

Followed:

Other

GLP: No Data

Method/Guideline and

Test Condition Remarks:

Test Results - Acute Toxicity

Concentration (LC/LD) : LC/LD % Value

Description

Value/Lower

Concentration

Upper

Concentration

Units

LD 50 % > 2000 mg/kgbw

Number of Deaths ( Male

):

Number of Deaths ( Female

):

Number of Deaths ( Total

):

Results Remarks:

Conclusion:

Reliability/Data Quality - Acute Toxicity

Reliability: 3 - Not Valid

Reliability Remarks:

Key Study Sponsor

Indicator:

Reference - Acute Toxicity

Reference: IUCLID dataset

 Acute Toxicity

CAS Number : 118-48-9
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Sponsored Chemical Name

:

2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance - Acute Toxicity

Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance

Purity/Composition

and Other Test Substance

Comments:

Sponsored Chemical Result

Type:

Measured

Method - Acute Toxicity

Route of Administration: Inhalation

Type of Exposure: No Data

Species: Rat

Mammalian Strain: No Data

Gender:

Number of Animals per

Dose:

Concentration:

Year Study Performed: 1963

Method/Guideline

Followed:

Other

GLP: Not Applicable

Method/Guideline and

Test Condition Remarks:

exposure duration: 4 hours

method: dynamische Inhalation nach Niessen et al.: Arch.

Toxicol. 20, 44 

Test Results - Acute Toxicity

Concentration (LC/LD) : LC/LD % Value

Description

Value/Lower

Concentration

Upper

Concentration

Units

LC 50 % > 0.348 mg/L

Number of Deaths ( Male

):

Number of Deaths ( Female

):

Number of Deaths ( Total

):

Results Remarks:
High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

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Conclusion:

Reliability/Data Quality - Acute Toxicity

Reliability: 3 - Not Valid

Reliability Remarks: Summary is in German

Key Study Sponsor

Indicator:

Reference - Acute Toxicity

Reference: IUCLID dataset

 Acute Toxicity

CAS Number : 118-48-9

Sponsored Chemical Name

:

2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance - Acute Toxicity

Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance

Purity/Composition

and Other Test Substance

Comments:

Sponsored Chemical Result

Type:

Measured

Method - Acute Toxicity

Route of Administration: Inhalation

Type of Exposure: No Data

Species: Rat

Mammalian Strain: No Data

Gender:

Number of Animals per

Dose:

Concentration:

Year Study Performed: 1981

Method/Guideline

Followed:

OECD 403

GLP: No

Method/Guideline and

Test Condition Remarks:

exposure duration: 4 hours

Test Results - Acute Toxicity
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Concentration (LC/LD) : LC/LD % Value

Description

Value/Lower

Concentration

Upper

Concentration

Units

LC 50 % > 5.3 mg/L

Number of Deaths ( Male

):

Number of Deaths ( Female

):

Number of Deaths ( Total

):

Results Remarks:

Conclusion:

Reliability/Data Quality - Acute Toxicity

Reliability: 3 - Not Valid

Reliability Remarks: Summary is in German

Key Study Sponsor

Indicator:

Reference - Acute Toxicity

Reference: IUCLID dataset

 Acute Toxicity

CAS Number : 118-48-9

Sponsored Chemical Name

:

2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance - Acute Toxicity

Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance

Purity/Composition

and Other Test Substance

Comments:

Sponsored Chemical Result

Type:

Measured

Method - Acute Toxicity

Route of Administration: Oral

Type of Exposure: No Data
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Species: Hen

Mammalian Strain: No Data

Gender:

Number of Animals per

Dose:

Dose:

Year Study Performed:

Method/Guideline

Followed:

Other

GLP:

Method/Guideline and

Test Condition Remarks:

Test Results - Acute Toxicity

Concentration (LC/LD) : LC/LD % Value

Description

Value/Lower

Concentration

Upper

Concentration

Units

LD 50 % > 2500 mg/kgbw

Number of Deaths ( Male

):

Number of Deaths ( Female

):

Number of Deaths ( Total

):

Results Remarks:

Conclusion:

Reliability/Data Quality - Acute Toxicity

Reliability: 3 - Not Valid

Reliability Remarks: Summary is in German

Key Study Sponsor

Indicator:

Reference - Acute Toxicity

Reference: IUCLID dataset

 Acute Toxicity
High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint[6/15/2011 10:42:13 AM]

CAS Number : 118-48-9

Sponsored Chemical Name

:

2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance - Acute Toxicity

Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance

Purity/Composition

and Other Test Substance

Comments:

Sponsored Chemical Result

Type:

Measured

Method - Acute Toxicity

Route of Administration: Oral

Type of Exposure: No Data

Species: Mouse

Mammalian Strain: No Data

Gender:

Number of Animals per

Dose:

Dose:

Year Study Performed:

Method/Guideline

Followed:

Other

GLP:

Method/Guideline and

Test Condition Remarks:

Test Results - Acute Toxicity

Concentration (LC/LD) : LC/LD % Value

Description

Value/Lower

Concentration

Upper

Concentration

Units

LD 50 % > 1000 mg/kgbw

Number of Deaths ( Male

):

Number of Deaths ( Female

):

Number of Deaths ( Total

):
High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

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Results Remarks:

Conclusion:

Reliability/Data Quality - Acute Toxicity

Reliability: 3 - Not Valid

Reliability Remarks: Summary is in German.

Key Study Sponsor

Indicator:

Reference - Acute Toxicity

Reference: IUCLID dataset

 Acute Toxicity

CAS Number : 118-48-9

Sponsored Chemical Name

:

2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance - Acute Toxicity

Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance

Purity/Composition

and Other Test Substance

Comments:

Sponsored Chemical Result

Type:

Measured

Method - Acute Toxicity

Route of Administration: Inhalation

Type of Exposure: No Data

Species: Rat

Mammalian Strain: No Data

Gender:

Number of Animals per

Dose:

Concentration:

Year Study Performed: 1963

Method/Guideline

Followed:

Other

GLP: Not Applicable

Method/Guideline and

Test Condition Remarks:

exposure duration: 4 hours

method: dynamische Inhalation nach Niessen et al.: Arch.
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Toxicol. 20, 44 

Test Results - Acute Toxicity

Concentration (LC/LD) : LC/LD % Value

Description

Value/Lower

Concentration

Upper

Concentration

Units

LC 50 % > 0.255 mg/L

Number of Deaths ( Male

):

Number of Deaths ( Female

):

Number of Deaths ( Total

):

Results Remarks:

Conclusion:

Reliability/Data Quality - Acute Toxicity

Reliability: 3 - Not Valid

Reliability Remarks: Summary is in German

Key Study Sponsor

Indicator:

Reference - Acute Toxicity

Reference: IUCLID dataset

 Acute Toxicity

CAS Number : 118-48-9

Sponsored Chemical Name

:

2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance - Acute Toxicity

Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance

Purity/Composition

and Other Test Substance

Comments:

Sponsored Chemical Result

Type:

Measured

Method - Acute Toxicity

Route of Administration: Oral
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Type of Exposure: No Data

Species: Rat

Mammalian Strain: No Data

Gender:

Number of Animals per

Dose:

Dose:

Year Study Performed:

Method/Guideline

Followed:

Other

GLP:

Method/Guideline and

Test Condition Remarks:

BASF Test

Test Results - Acute Toxicity

Concentration (LC/LD) : LC/LD % Value

Description

Value/Lower

Concentration

Upper

Concentration

Units

LD 50 % > 6400 mg/kgbw

Number of Deaths ( Male

):

Number of Deaths ( Female

):

Number of Deaths ( Total

):

Results Remarks:

Conclusion:

Reliability/Data Quality - Acute Toxicity

Reliability: 3 - Not Valid

Reliability Remarks: Summary is in German.

Key Study Sponsor

Indicator:

Reference - Acute Toxicity

Reference: IUCLID dataset
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 Acute Toxicity

CAS Number : 118-48-9

Sponsored Chemical Name

:

2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance - Acute Toxicity

Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance

Purity/Composition

and Other Test Substance

Comments:

Sponsored Chemical Result

Type:

Measured

Method - Acute Toxicity

Route of Administration: Inhalation

Type of Exposure: Aerosol

Species: No data

Mammalian Strain: No Data

Gender:

Number of Animals per

Dose:

Concentration:

Year Study Performed:

Method/Guideline

Followed:

Other

GLP: No Data

Method/Guideline and

Test Condition Remarks:

exposure duration: 4 hours

Aerosol was tested.

Test Results - Acute Toxicity

Concentration (LC/LD) : LC/LD % Value

Description

Value/Lower

Concentration

Upper

Concentration

Units

Number of Deaths ( Male

):

Number of Deaths ( Female

):
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Number of Deaths ( Total

):

Results Remarks:

Conclusion:

Reliability/Data Quality - Acute Toxicity

Reliability: 3 - Not Valid

Reliability Remarks: Summary is in German

Key Study Sponsor

Indicator:

Reference - Acute Toxicity

Reference: IUCLID dataset

 Acute Toxicity

CAS Number : 118-48-9

Sponsored Chemical Name

:

2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance - Acute Toxicity

Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance

Purity/Composition

and Other Test Substance

Comments:

Sponsored Chemical Result

Type:

Measured

Method - Acute Toxicity

Route of Administration: Dermal

Type of Exposure: No Data

Species: Rat

Mammalian Strain: No Data

Gender:

Number of Animals per

Dose:

Dose:

Year Study Performed:

Method/Guideline

Followed:

Other

GLP: No Data
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Method/Guideline and

Test Condition Remarks: Method/guideline followed: offene Applikation, intakte Haut, 7

Tauge 

Test Results - Acute Toxicity

Concentration (LC/LD) : LC/LD % Value

Description

Value/Lower

Concentration

Upper

Concentration

Units

LD 50 % > 500 mg/kgbw

Number of Deaths ( Male

):

Number of Deaths ( Female

):

Number of Deaths ( Total

):

Results Remarks:

Conclusion:

Reliability/Data Quality - Acute Toxicity

Reliability: 3 - Not Valid

Reliability Remarks: Summary is in German

Key Study Sponsor

Indicator:

Reference - Acute Toxicity

Reference: IUCLID dataset

 Repeated-Dose Toxicity

CAS Number : 118-48-9

Sponsored Chemical

Name :

2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance - Repeated-Dose Toxicity

Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance

Purity/Composition

and Other Test

Substance Comments:

Sponsored Chemical

Result Type:

Measured

Method - Repeated-Dose Toxicity
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Route of

Administration:

Oral

Type of Exposure: No Data

Species: Rat

Mammalian Strain: Wistar

Gender: Male

Number of Animals per

Dose:

Dose: 1000 mg/kg (max dose)

Year Study Performed: 1961

Method/Guideline

Followed:

Other

GLP: No

Exposure Period: 5 Days

Frequency of

Treatment:

daily

Post-Exposure Period: 6 Days

Method/Guideline and

Test Condition

Remarks:

Method/guideline followed: in Anlehnung an Lim et al.: Arch. Int.

Pharmacol. 130, 336

Control group and treatment: Not specified.

Post-observation period: 6-13 days

Statistical methods: Cannot ascertain - study is in German.

Method remarks: Remarks are in German.

Test Results - Repeated-Dose Toxicity

Concentration (LOAEL/

LOAEC/ NOAEL/

NOAEC) :

LOAEL/

LOAEC/

NOAEL/

NOAEC

Population Value

Description

Value/Lower

Concentration

Upper

Concentration

Units

Results Remarks:

Conclusion:

Reliability/Data Quality - Repeated-Dose Toxicity

Reliability: 3 - Not Valid
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Reliability Remarks: Summary is in German

Key Study Sponsor

Indicator:

Reference - Repeated-Dose Toxicity

Reference: IUCLID dataset

 Repeated-Dose Toxicity

CAS Number : 118-48-9

Sponsored Chemical

Name :

2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance - Repeated-Dose Toxicity

Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance

Purity/Composition

and Other Test

Substance Comments:

Sponsored Chemical

Result Type:

Measured

Method - Repeated-Dose Toxicity

Route of

Administration:

Inhalation

Type of Exposure: Aerosol

Species: Rat

Mammalian Strain: Wistar

Gender: Both M/F

Number of Animals per

Dose:

Concentration: 0.197 mg/L

Year Study Performed: 1963

Method/Guideline

Followed:

Other

GLP: No

Exposure Period: 5 Days

Frequency of

Treatment:

4 hours a day

Post-Exposure Period: 2 Weeks

Method/Guideline and

Test Condition

Remarks:

Statistical methods: Cannot ascertain - study is in German.
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Method remarks: Remarks are in German.

Test Results - Repeated-Dose Toxicity

Concentration (LOAEL/

LOAEC/ NOAEL/

NOAEC) :

LOAEL/

LOAEC/

NOAEL/

NOAEC

Population Value

Description

Value/Lower

Concentration

Upper

Concentration

Units

Results Remarks: LC50 > 0.197 mg/L

Conclusion:

Reliability/Data Quality - Repeated-Dose Toxicity

Reliability: 3 - Not Valid

Reliability Remarks: Summary is in German

Key Study Sponsor

Indicator:

Reference - Repeated-Dose Toxicity

Reference: IUCLID dataset

 Repeated-Dose Toxicity

CAS Number : 118-48-9

Sponsored Chemical

Name :

2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance - Repeated-Dose Toxicity

Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance

Purity/Composition

and Other Test

Substance Comments:

Sponsored Chemical

Result Type:

Measured

Method - Repeated-Dose Toxicity

Route of

Administration:

Inhalation

Type of Exposure: Aerosol

Species: Rat
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Mammalian Strain: Wistar

Gender: Both M/F

Number of Animals per

Dose:

Concentration: 0.0116; 0.071 mg/L (DMSO and Lutol 1:1)

Year Study Performed: 1963

Method/Guideline

Followed:

Other

GLP: No

Exposure Period: 28 Days

Frequency of

Treatment:

4 hours a day, 5 days a week over 28 days

Post-Exposure Period:

Method/Guideline and

Test Condition

Remarks:

Method/guideline followed: dynamische Inhalation nach Niessen et

al.: Arch. Toxicol. 20, 44

Control group and treatment: Yes, concurrent vehicle

Post-observation period: None

Statistical methods: Cannot ascertain - study is in German.

Method remarks: Remarks are in German.

Test Results - Repeated-Dose Toxicity

Concentration (LOAEL/

LOAEC/ NOAEL/

NOAEC) :

LOAEL/

LOAEC/

NOAEL/

NOAEC

Population Value

Description

Value/Lower

Concentration

Upper

Concentration

Units

NOAEC = 0.0116 mg/L

Results Remarks:

Conclusion:

Reliability/Data Quality - Repeated-Dose Toxicity

Reliability: 3 - Not Valid

Reliability Remarks: Summary is in German

Key Study Sponsor

Indicator:

Reference - Repeated-Dose Toxicity
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Reference: IUCLID dataset

 Genetic Toxicity in vivo

CAS Number : 118-48-9

Sponsored Chemical Name

:

2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance - Genetic Toxicity in vivo

Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance

Purity/Composition

and Other Test Substance

Comments:

Sponsored Chemical Result

Type:

Measured

Method - Genetic Toxicity in vivo

Type of Study: Bone Marrow Chromosomal Aberration

Type of Test: Micronucleus assay

Route of Administration: Oral

Type of Exposure: Gavage

Species: Mouse

Strain: NMRI

Gender: Both M/F

Dose: Test substance was administered at 200, 670, 2000 mg/kg (24 h

preparation interval), 2000 mg/kg (48 hour preparation

interval)

Year Study Performed: 1983

Method/Guideline

Followed:

OECD 474

GLP: Yes

Duration of Treatment/

Exposure Period and

Units:

Frequency of Treatment:

Positive, Negative, and

Solvent

Control Substance(s):

Number of Animals per Sex

and Dose Group:

Method/Guideline and

Test Condition Remarks:

Test Results - Genetic Toxicity in vivo
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Systemic Toxicity: Unknown

Genotoxic Effect: Unknown

Results Remarks: Summary in German.

Conclusion:

Reliability/Data Quality - Genetic Toxicity in vivo

Reliability: 3 - Not Valid

Reliability Remarks:

Key Study Sponsor

Indicator:

Reference - Genetic Toxicity in vivo

Reference: IUCLID dataset

 Genetic Toxicity in vitro

CAS Number : 118-48-9

Sponsored Chemical

Name :

2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance - Genetic Toxicity in vitro

Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance

Purity/Composition

and Other Test

Substance

Comments:

Sponsored Chemical

Result Type:

Measured

Method - Genetic Toxicity in vitro

Type of Study: Bacterial reverse mutation assay

Concentrations: 20 μg - 5000 μg/plate

Year Study

Performed:

1975

Method/Guideline

Followed:

Other

GLP: No

Postive, Negative, and

Solvent

Control Substance(s):

Method/Guideline and

Test Condition

Remarks:

Method/guideline followed: in Anlehnung an: Ames B.N. et al.:

Proc. Natl. Acad. Sci. USA 70, 2281-

2285, (1973) und Ames, B.N. et al.: Mut. Res. 31, 347-364, (1975)

Test system: Bacterial cell, in vitro

Species/Strain/cell-type/cell line: Salmonella typhimurium TA1535,
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TA100, TA1537, TA98

Metabolic activation: With and without

Concentrations tested: 20 μg - 5000 μg/plate

Remarks: Standard test plate.

Test Results - Genetic Toxicity in vitro

Details on Cytogenetic

Assay:

Statistics:

Effect : Species Other

Species

Strain Other

Strain

Metabolic

Activation

Genotoxic

Effect

Conclusion

Bacteria S.

typhimurium

TA 1535

With and

Without

Negative

Bacteria S.

typhimurium

TA 100

With and

Without

Negative

Bacteria S.

typhimurium

TA 1537

With and

Without

Negative

Bacteria S.

typhimurium

TA 98

With and

Without

Negative

Results Remarks: Negative

Conclusion:

Reliability/Data Quality - Genetic Toxicity in vitro

Reliability: 3 - Not Valid

Reliability Remarks:

Key Study Sponsor

Indicator:

Reference - Genetic Toxicity in vitro

Reference: IUCLID dataset

 Reproductive Toxicity

CAS Number : 118-48-9

Sponsored Chemical

Name :

2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance - Reproductive Toxicity

Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance
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Purity/Composition

and Other Test

Substance Comments:

Sponsored Chemical

Result Type:

Measured

Method - Reproductive Toxicity

Route of

Administration:

Subcutaneous

Type of Exposure:

Species: Mouse

Mammalian Strain: Swiss

Gender: Female

Number of Animals per

Dose:

Dose: 4 mg, 8 mg

Year Study Performed:

Method/Guideline

Followed:

Other

GLP: No

Exposure Period: 5 - 6.5 Days

Frequency of

Treatment:

Post-Exposure Period:

Method/Guideline and

Test Condition

Remarks:

Exposure period: 5 days; pre-mating exposure was 1.5 days for

females.

Frequency of treatment: Cannot ascertain - in German.

Control group and treatment: Yes (treatment not specified)

Pre-Mating Exposure /

Males:

Pre-Mating Exposure /

Females:

Test Results - Reproductive Toxicity

Concentration (LOAEL/

LOAEC/ NOAEL/

NOAEC) :

LOAEL/

LOAEC/

NOAEL/

NOAEC

Population Value

Description

Value/Lower

Concentration

Upper

Concentration

Units
High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint[6/15/2011 10:42:13 AM]

Results: Remarks are in German.

Results Remarks:

Conclusion:

Reliability/Data Quality - Reproductive Toxicity

Reliability: 3 - Not Valid

Reliability Remarks:

Key Study Sponsor

Indicator:

Reference - Reproductive Toxicity

Reference: IUCLID dataset