### SAT Report PMN Number: P-10-0476 SAT Date: 8/10/2010 Print Date: 5/2/2011

Related cases : CBI : Yes Health related cases: Ecotox related cases: N o reasonable analogs were found.

Concern levels : Type of Concern: Health Eco Comments Level of Concern: 1-2 1

Persistence Bioaccum Toxicity Comments 3 11

Exposure Based Review : Health: Yes Exposure based testing (health): Inhalation only Ecotox: N o
Routes of exposure : Health: Inhalation Ecotox: N o releases to water Fate: ; Keywords : Keywords: LUNG
Summary of Assessment :

Fate : Fate Summary: P-10-0476 FATE: Solid S = N egl. VP < 1.0E-6 torr at 25 C (E) BP > 400 C (E) H < 1.00E-8 (E) POTW removal (%) = 90 via sorption; OECD 111 (Hydrolysis): t1/2( p H1.2,4,7,9): 0.08 +/- 0.06%/5d; OECD311(AnaerobicBiodeg): 0%/62d. Time for complete ultimate aerobic biodeg > mo Sorption to soils/sediments = v.strongPBT Potential: P3B1 *CEB FATE: Migration to ground water = negl

Health : Health Summary: Absorption is nil all routes based on physical/chemical p roperties. Here is concern for lung effects from lung overload if respirable particles are inhaled based on the high molecular weight of the PMN material ( . Low moderate

concern. Test Data: inconclusive negative in Salmonella and E coli, test was conducted with activation only inconclusive negative for chromosome aberrations in rat lymphocytes, not explanation of dose selection was provided combined repeated dose/developmental/reproductive study in rats (100, 300, 1000 mg/kg) - no effects seen, N OEL = 1000 mg/k not a dermal sensitizer in guinea pigs, guinea pig maximization test eye irritant in rabbits, effects cleared by 72 hours acute oral study in rats - no deaths or signs of toxicity at 2000 mg/kg mild skin irritant in rabbits, cleared by 24 hours acute oral study in mice, multiple results reported - Ld50 values were either greater than 5000 mg/kg or between 500 and 5000 mg/kg

Ecotox :

Test Organism Test Type Test End Point Predicted Measured Comments

fish 96-h LC50 * daphnid 48-h LC50 * * green algal 96-h EC50 * fish

_ chronic value * daphnid

_ chronic value * algal

_ chronic value * Sewage Sludge 3-h EC50

_ Sewage Sludge

_ Chronic Value

_ Ecotox Values Comments: Predictions are based on SARs for nonionic polymers; SAR chemical class = p olyme r -nonionic-insoluble; solid with mp unk; S < 0.001 mg/L at 25 C (P); p H7; effective concentrations based on 100% active ingredients and nominal concentrations; hardness <150.0 mg/L as CaCO3; and TOC <2.0 mg/L;
A single acute daphnia study accompanied the submission. This study complied with OPPTS and OECD guidelines for: 1) O2, p H, temperature, water hardness values and other water quality p arameters; 2) species, age, number of organisms per replicate, and biomass loading rates; and, 3) replicate and overall variability. Because of the very low water solubility of the PMN, only one nominal loading rate concentration (1,000 mg/L) was tested. This limit test was essentiallyan assay of the water accommodated fraction (WAF). N o attempt was made to measure the concentration of the PMN analytically. Results indicated no mortalities or effects on behavior in the treatment groups consistent with No Effects at Saturation as predicted by ECOSAR.

Factors Values Comments Assessment Factor 10 Concentration of Concern ( p pb) *

SARs nonionic polymers SAR Class p olyme r -nonionic-brominated hydrocarbon

Ecotox Factors Comments:

SAT Chair: Becky Jones