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  <xs:element name="ShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice" id="pgnx_ShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" />
  <xs:element name="RestructuringChargesAmountPayableInCommonStockShares" id="pgnx_RestructuringChargesAmountPayableInCommonStockShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="instant" />
  <xs:element name="CommonStockSoldInPublicOfferingInShares" id="pgnx_CommonStockSoldInPublicOfferingInShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" />
  <xs:element name="MipMember" id="pgnx_MipMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="MaximumMilestonePaymentSpecifiedCommercialEvents" id="pgnx_MaximumMilestonePaymentSpecifiedCommercialEvents" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" />
  <xs:element name="MaximumMilestonePaymentForAchievingSalesTargets" id="pgnx_MaximumMilestonePaymentForAchievingSalesTargets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" />
  <xs:element name="DeferredLeaseTableTextBlock" id="pgnx_DeferredLeaseTableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" />
  <xs:element name="UpfrontLicenseFeeReceivable" id="pgnx_UpfrontLicenseFeeReceivable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" />
  <xs:element name="CurrentLeaseIncentivePayable" id="pgnx_CurrentLeaseIncentivePayable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" />
  <xs:element name="UpfrontPaymentReceivable" id="pgnx_UpfrontPaymentReceivable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" />
  <xs:element name="CommonStockOfferingPrice" id="pgnx_CommonStockOfferingPrice" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" />
  <xs:element name="DecreaseInCashCashEquivalentsAndAuctionRateSecurities" id="pgnx_DecreaseInCashCashEquivalentsAndAuctionRateSecurities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" />
  <xs:element name="NetDeferredTaxAssetLiability" id="pgnx_NetDeferredTaxAssetLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" />
  <xs:element name="CommonStockUnderwritingDiscountsAndCommissions" id="pgnx_CommonStockUnderwritingDiscountsAndCommissions" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" />
  <xs:element name="CommonStockOfferingExpenses" id="pgnx_CommonStockOfferingExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" />
  <xs:element name="MedimmuneUpfrontPaymentReceivable" id="pgnx_MedimmuneUpfrontPaymentReceivable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" />
  <xs:element name="MedimmuneAgreementMember" id="pgnx_MedimmuneAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="CytodynAgreementMember" id="pgnx_CytodynAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="NonEmployeesMember" id="pgnx_NonEmployeesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="NetLossIncomePerShareAbstract" id="pgnx_NetLossIncomePerShareAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="MedimmuneMember" id="pgnx_MedimmuneMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="CytodynMember" id="pgnx_CytodynMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="SalixMember" id="pgnx_SalixMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="SharesIssuedForAcquisition" id="pgnx_SharesIssuedForAcquisition" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="instant" />
  <xs:element name="SharesForAcquisitionHeldInEscrow" id="pgnx_SharesForAcquisitionHeldInEscrow" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="instant" />
  <xs:element name="ClosingPriceOfProgenicsCommonShares" id="pgnx_ClosingPriceOfProgenicsCommonShares" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="instant" />
  <xs:element name="DeferredTaxAssetsNetLabel" id="pgnx_DeferredTaxAssetsNetLabel" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" />
  <xs:element name="CommitmentsPaidFromInception" id="pgnx_CommitmentsPaidFromInception" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" />
  <xs:element name="ConsultingAgreementMonthlyRetainerAmount" id="pgnx_ConsultingAgreementMonthlyRetainerAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" />
  <xs:element name="SuccessFeeAmountPayable" id="pgnx_SuccessFeeAmountPayable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" />
  <xs:element name="LeaseholdImprovementsNet" id="pgnx_LeaseholdImprovementsNet" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" />
</xs:schema>
</XBRL>