NCHS Data Brief ■ No. 394 ■ December 2020

U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES

Centers for Disease Control and Prevention

National Center for Health Statistics

Drug Overdose Deaths in the United States, 1999–2019

Holly Hedegaard, M.D., Arialdi M. Miniño, M.P.H., and Margaret Warner, Ph.D.

Key findings

Data from the National 

Vital Statistics System, 

Mortality

● The age-adjusted rate of 

drug overdose deaths in 2019 

(21.6 per 100,000) was higher 

than in 2018 (20.7). 

● In 2019, adults aged 35–44 

had the highest rate of drug 

overdose deaths (40.5 per 

100,000). 

● The average annual increase 

in the rate of drug overdose 

deaths involving synthetic 

opioids other than methadone 

was lower from 2017 through 

2019 (9% per year) than from 

2013 through 2017 (75%). 

● In 2019, the rates of 

drug overdose deaths 

involving heroin, natural 

and semisynthetic opioids, 

and methadone were lower 

than in 2018.

● From 2012 through 2019, 

the rate of drug overdose deaths 

involving cocaine increased 

more than 3-fold (from 1.4 to 

4.9), while those involving 

psychostimulants with abuse 

potential increased more than 

6-fold (from 0.8 to 5.0).

Deaths from drug overdose continue to be a public health burden in the 

United States (1–5). This report uses the most recent data from the National 

Vital Statistics System (NVSS) to update statistics on deaths from drug 

overdose in the United States, including information on trends from 1999 

through 2019 by sex and age group, and by specific types of drugs involved 

(i.e., opioids and stimulants). 

In 2019, the age-adjusted rate of drug overdose deaths in the 

United States was higher than the rate in 2018.

● In 2019, 70,630 drug overdose deaths occurred in the United States for 

an age-adjusted rate of 21.6 per 100,000 standard population (Figure 1). 

● The age-adjusted rate of drug overdose deaths increased from 1999 

through 2017, with different rates of change over time. The rate in 2018 

Figure 1. Age-adjusted drug overdose death rates, by sex: United States, 1999–2019

1Rates for males were significantly higher than rates for females for all years, p < 0.05.

NOTES: Significant increasing trend from 1999 through 2017, with different rates of change over time for all groups, p < 0.05. Drug 

overdose deaths are identified using the International Classification of Diseases, 10th Revision (ICD–10) underlying 

cause-of-death codes X40–X44, X60–X64, X85, and Y10–Y14. Age-adjusted death rates were calculated using the direct method 

and the 2000 U.S. standard population. The number of drug overdose deaths in 2019 was 70,630. Access data table for Figure 1 

at: https://www.cdc.gov/nchs/data/databriefs/db394-tables-508.pdf#1.

SOURCE: National Center for Health Statistics, National Vital Statistics System, Mortality. Deaths per 100,000 standard population

30

25

20

15

10

5

0

1999 2001 2003

Male1

Total

Female

2005 2007 2009 2011 2013 2015 2017 2019

NCHS reports can be downloaded from: https://www.cdc.gov/nchs/products/index.htm.
NCHS Data Brief ■ No. 394 ■ December 2020

■  2  ■

(20.7) was significantly lower than the rate in 2017 (21.7). The rate in 2019 (21.6) was 

significantly higher than the rate in 2018 and similar to the rate in 2017.

● The rate for males was higher than for females throughout the entire period.

● For males, the rate increased from 8.2 in 1999 to 29.1 in 2017, decreased to 27.9 in 2018, 

and increased to 29.6 in 2019. The rate for males in 2019 was significantly higher than the 

rate in 2017 and 2018.

● For females, the rate increased from 3.9 in 1999 to 14.4 in 2017, then decreased to 13.6 in 

2018 and 13.7 in 2019. The rate for females in 2019 was not significantly different from the 

rate in 2018, and was lower than the rate in 2017.

Among persons aged 15 and over, adults aged 35–44 had the highest rate 

of drug overdose deaths in 2019.

● The rate of drug overdose deaths increased from 1999 through 2019 for all groups aged 

15 and over, although the patterns of increase varied by age group, with different rates of 

change over time (Figure 2). 

Figure 2. Drug overdose death rates among those aged 15 and over, by selected age group: United States, 1999–2019

1Significant increasing trend from 1999 through 2017, with different rates of change over time, p < 0.05. 2Rate in 2019 was significantly higher than the rate in 2018, p < 0.05. 3Age group with the highest rate in 2019, p < 0.05. 4Significant increasing trend from 1999 through 2006 and from 2013 through 2017, with different rates of change over time, p < 0.05. 5Significant increasing trend from 1999 through 2019, with different rates of change over time, p < 0.05. 

NOTES: Drug overdose deaths are identified using the International Classification of Diseases, 10th Revision (ICD–10) underlying cause-of-death codes 

X40–X44, X60–X64, X85, and Y10–Y14. Access data table for Figure 2 at: https://www.cdc.gov/nchs/data/databriefs/db394-tables-508.pdf#2.

SOURCE: National Center for Health Statistics, National Vital Statistics System, Mortality. Deaths per 100,000 population

1999 2001 2003 2005 2007 2009 2011 2013 2015 2017 2019

50

40

30

20

10

0

45–541,2

35–441–3

25–341

55–641,2

15–242,4

65 and over2,5
NCHS Data Brief ■ No. 394 ■ December 2020

■  3  ■

● Among persons aged 15 and over, the rate in 2019 was highest for persons aged 35–44

(40.5 per 100,000). 

● For all age groups except 25–34, the rate in 2019 was significantly higher than the rate 

in 2018. 

Rates of drug overdose deaths involving heroin, natural and semisynthetic 

opioids, and methadone decreased between 2018 and 2019, while the rate 

of overdose deaths involving synthetic opioids other than methadone 

continued to increase.

● The age-adjusted rate of drug overdose deaths involving synthetic opioids other than 

methadone, which include drugs such as fentanyl, fentanyl analogs, and tramadol, increased 

from 1.0 per 100,000 in 2013 to 11.4 in 2019. The average annual increase in the rate was 

lower from 2017 through 2019 (9% per year) than from 2013 through 2017 (75% per year) 

(Figure 3).

● The age-adjusted rate of drug overdose deaths involving heroin was stable from 1999 

through 2005, then increased from 0.7 in 2005 to 4.9 in 2016 and 2017. From 2016 through 

2019, the rate decreased from 4.9 to 4.4.

Figure 3. Age-adjusted rates of drug overdose deaths involving opioids, by type of opioid: United States, 1999–2019

1Significant increasing trend from 1999 through 2006 and 2013 through 2019, with different rates of change over time, p < 0.05. 2Significant increasing trend from 1999 through 2017, with different rates of change over time, p < 0.05. 3Significant increasing trend from 2005 to 2016, with different rates of change over time, then significant decreasing trend from 2016 through 2019, p < 0.05. 4Significant increasing trend from 1999 to 2006, with different rates of change over time, then significant decreasing trend from 2006 through 2019, p < 0.05.

NOTES: Drug overdose deaths are identified using the International Classification of Diseases, 10th Revision (ICD–10) underlying cause-of-death codes 

X40–X44, X60–X64, X85, and Y10–Y14. Drug overdose deaths involving selected drug categories are identified by specific multiple-cause-of-death codes: heroin, 

T40.1; natural and semisynthetic opioids, T40.2; methadone, T40.3; and synthetic opioids other than methadone, T40.4. Deaths involving more than one opioid 

category (e.g., a death involving both methadone and a natural or semisynthetic opioid) are counted in both categories. Natural and semisynthetic opioids include 

drugs such as morphine, oxycodone, and hydrocodone; and synthetic opioids other than methadone include drugs such as fentanyl, fentanyl analogs, and 

tramadol. The percentage of drug overdose deaths that identified the specific drugs involved varied by year, ranging from 75%–79% from 1999 through 2013 and 

increasing from 81% in 2014 to 94% in 2019. Access data table for Figure 3 at: https://www.cdc.gov/nchs/data/databriefs/db394-tables-508.pdf#3.

SOURCE: National Center for Health Statistics, National Vital Statistics System, Mortality. Deaths per 100,000 standard population

1999 2001 2003 2005 2007 2009 2011 2013 2015 2017 2019

12

10

8

6

4

2

0

Synthetic opioids other 

than methadone1

Heroin3

Methadone4

Natural and 

semisynthetic opioids2
NCHS Data Brief ■ No. 394 ■ December 2020

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● The age-adjusted rate of drug overdose deaths involving natural and semisynthetic opioids, 

which include drugs such as oxycodone and hydrocodone, increased from 1.0 in 1999 to 

3.7 in 2011, then increased again to 4.4 in 2016 and 2017. The rates in 2018 (3.8) and 2019 

(3.6) were lower than the rate in 2017 (4.4).

● The rate of drug overdose deaths involving methadone increased from 0.3 in 1999 to 1.8 

in 2006 and 2007. From 2006 through 2019, the rate decreased on average by 6% per year 

(from 1.8 to 0.8).

From 2012 through 2019, the age-adjusted rates of drug overdose deaths 

involving cocaine and psychostimulants with abuse potential continued 

their increases from previous years.

● The age-adjusted rate of drug overdose deaths involving cocaine increased from 1.4 per 

100,000 in 1999 to 2.5 in 2006, then decreased to 1.4 in 2012. From 2012 through 2019, the 

rate more than tripled from 1.4 in 2012 to 4.9 in 2019 (Figure 4). 

● The age-adjusted rate of drug overdose deaths involving psychostimulants with 

abuse potential, which include drugs such as methamphetamine, amphetamine, and 

methylphenidate, increased from 0.2 in 1999 to 0.5 in 2005, remained stable from 2005 

through 2008, then increased from 0.4 in 2008 to 5.0 in 2019. From 2012 through 2019, the 

rate increased on average by 29% per year.

Figure 4. Age-adjusted rates of drug overdose deaths involving stimulants, by type of stimulant: United States, 1999–2019

1Significant increasing trend from 1999 to 2006, decreasing trend from 2006 to 2012, and increasing trend from 2012 through 2019, with different rates of change 

over time, p < 0.05 2Significant increasing trend from 1999 through 2005 and 2008 through 2019, with different rates of change over time, p < 0.05. 

NOTES: Drug overdose deaths are identified using the International Classification of Diseases, 10th Revision (ICD–10) underlying cause-of-death codes 

X40–X44, X60–X64, X85, and Y10–Y14. Drug overdose deaths involving selected drug categories are identified by specific multiple-cause-of-death codes: 

cocaine, T40.5; and psychostimulants, T43.6. Psychostimulants with abuse potential include drugs such as methamphetamine, amphetamine, and 

methylphenidate. Deaths may involve more than one drug. The percentage of drug overdose deaths that identified the specific drugs involved varied by year, 

ranging from 75%–79% from 1999 through 2013 and increasing from 81% in 2014 to 94% in 2019. Access data table for Figure 4 at: 

https://www.cdc.gov/nchs/data/databriefs/db394-tables-508.pdf#4.

SOURCE: National Center for Health Statistics, National Vital Statistics System, Mortality. Deaths per 100,000 standard population

1999 2001 2003 2005 2007 2009 2011 2013 2015 2017 2019

12

10

8

6

4

2

0

Psychostimulants 

with abuse potential2

Cocaine1
NCHS Data Brief ■ No. 394 ■ December 2020

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Summary

Although the rate of drug overdose deaths was significantly lower in 2018 than in 2017 (20.7 

and 21.7 per 100,000, respectively), the rate in 2019 (21.6) was higher than the 2018 rate and 

similar to the 2017 rate. From 2018 through 2019, rates for males increased (from 27.9 to 29.6), 

while rates for females showed no significant change (13.6 in 2018 and 13.7 in 2019). From 1999 

through 2019, rates increased for all groups aged 15 and over, although the patterns of increase 

varied by age group, with different rates of change over time. In 2019, the rate was highest for 

adults aged 35–44 at 40.5 per 100,000. 

The rate of drug overdose deaths involving synthetic opioids other than methadone (drugs such 

as fentanyl, fentanyl analogs, and tramadol) continued to increase; however, the average rate of 

increase has slowed in the most recent years, from an average annual increase of 75% per year 

from 2013 through 2017 to 9% per year from 2017 through 2019. The rates of drug overdose 

deaths involving heroin, natural and semisynthetic opioids, and methadone were lower in 

2019 than in 2018 (from 4.7 in 2018 to 4.4 in 2019 for heroin, from 3.8 in 2018 to 3.6 in 2019 

for natural and semisynthetic opioids, and from 0.9 in 2018 to 0.8 in 2019 for methadone). In 

contrast, the rates of drug overdose deaths involving cocaine and psychostimulants with abuse 

potential (drugs such as methamphetamine) were higher in 2019 than in 2018 (from 4.5 in 2018 

to 4.9 in 2019 for cocaine, and from 3.9 in 2018 to 5.0 in 2019 for psychostimulants with abuse 

potential).

Definitions

Drug poisoning (overdose) deaths: Includes deaths resulting from unintentional or intentional 

overdose of a drug, being given the wrong drug, taking a drug in error, or taking a drug 

inadvertently. 

Natural and semisynthetic opioids: Includes drugs such as morphine, codeine, hydrocodone, and 

oxycodone. 

Synthetic opioids other than methadone: Includes drugs such as fentanyl, fentanyl analogs, and 

tramadol. 

Psychostimulants with abuse potential: Includes drugs such as methamphetamine, amphetamine, 

and methylphenidate. 
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Data source and methods

Estimates are based on the NVSS multiple-cause-of-death mortality files (6). Drug poisoning 

(overdose) deaths were defined as having an International Classification of Diseases, 10th 

Revision (ICD–10) underlying cause-of-death code of X40–X44 (unintentional), X60–X64 

(suicide), X85 (homicide), or Y10–Y14 (undetermined intent). Of the drug overdose deaths in 

2019, 88.0% were unintentional, 6.8% were suicides, 5.0% were of undetermined intent, and 

less than 1.0% were homicides. The type of drug(s) involved are indicated by ICD–10 multiplecause-of-death codes: heroin, T40.1; natural and semisynthetic opioids, T40.2; methadone, T40.3; 

synthetic opioids other than methadone, T40.4; cocaine, T40.5; and psychostimulants with abuse 

potential, T43.6.

Age-adjusted death rates were calculated using the direct method and adjusted to the 2000 

standard population (7). Trends in age-adjusted death rates were evaluated using the Joinpoint 

Regression Program (Version 4.8.0.1) (8). Joinpoint software fitted weighted least-squares 

regression models to the rates on the log transform scale. Analyses were set to allow a maximum 

of three joinpoints across the period, a minimum of three observed time points from any given 

joinpoint to either end of the data, and a minimum of four observed time points between any two 

joinpoints. The permutation tests for model (number of joinpoints) significance were set at an 

overall alpha level of 0.05 (9). Pairwise comparisons of rates (e.g., age-adjusted rates for males 

compared with females and year-to-year comparisons) were conducted using the z test with an 

alpha level of 0.05 (7). 

Several factors related to death investigation and reporting may affect measurement of death 

rates involving specific drugs. At autopsy, the substances tested for and the circumstances under 

which the toxicology tests are performed vary by jurisdiction. This variability is more likely to 

affect substance-specific death rates than the overall drug overdose death rate. The percentage 

of drug overdose deaths that identified the specific drugs involved varied by year, ranging from 

75%–79% from 1999 through 2013 and increasing from 81% in 2014 to 94% in 2019. 

Additionally, drug overdose deaths may involve multiple drugs; therefore, a death might be 

included in more than one category when describing the rate of drug overdose deaths involving 

specific drugs. For example, a death that involved both fentanyl and cocaine would be included 

in both the rate of drug overdose deaths involving synthetic opioids other than methadone and the 

rate of drug overdose deaths involving cocaine.
NCHS Data Brief ■ No. 394 ■ December 2020

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About the authors

Holly Hedegaard is with the National Center for Health Statistics (NCHS), Division of Analysis 

and Epidemiology. Arialdi M. Miniño and Margaret Warner are with NCHS, Division of Vital 

Statistics. 

References

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NCHS Data Brief, no 356. Hyattsville, MD: National Center for Health Statistics. 2020. Available 

from: https://www.cdc.gov/nchs/data/databriefs/db356-h.pdf. 

2. Ahmad FB, Rossen LM, Spencer MR, Warner M, Sutton P. Provisional drug overdose death 

counts. Vital Statistics Rapid Release. Hyattsville, MD: National Center for Health Statistics. 

2020. Available from: https://www.cdc.gov/nchs/nvss/vsrr/drug-overdose-data.htm. 

3. Hedegaard H, Spencer MR, Garnett MF. Increase in drug overdose deaths involving cocaine: 

United States, 2009–2018. NCHS Data Brief, no 384. Hyattsville, MD: National Center for 

Health Statistics. 2020. Available from: https://www.cdc.gov/nchs/data/databriefs/db384-H.pdf. 

4. O’Donnell J, Gladden RM, Mattson CL, Hunter CT, Davis NL. Vital signs: Characteristics of 

drug overdose deaths involving opioids and stimulants—24 states and the District of Columbia, 

January–June 2019. MMWR Morb Mortal Wkly Rep 69(35):1189–97. 2020. Available from: 

https://www.cdc.gov/mmwr/volumes/69/wr/mm6935a1.htm. 

5. Wilson N, Kariisa M, Seth P, Smith H IV, Davis NL. Drug and opioid-involved overdose 

deaths—United States, 2017–2018. MMWR Morb Mortal Wkly Rep 69(11):290–7. 2020. 

Available from: https://www.cdc.gov/mmwr/volumes/69/wr/mm6911a4.htm. 

6. National Center for Health Statistics. Public-use data files: Mortality multiple cause files. 

2019. Available from: https://www.cdc.gov/nchs/data_access/vitalstatsonline.htm#Mortality_

Multiple.

7. Kochanek KD, Murphy SL, Xu JQ, Arias E. Deaths: Final data for 2017. National Vital 

Statistics Reports; vol 68 no 9. Hyattsville, MD: National Center for Health Statistics. 2019. 

Available from: https://www.cdc.gov/nchs/data/nvsr/nvsr68/nvsr68_09-508.pdf.

8. National Cancer Institute. Joinpoint Regression Program (Version 4.8.0.1) [computer 

software]. 2019.

9. Ingram DD, Malec DJ, Makuc DM, Kruszon-Moran D, Gindi RM, Albert M, et al. National 

Center for Health Statistics guidelines for analysis of trends. National Center for Health Statistics. 

Vital Health Stat 2(179). 2018. Available from: https://www.cdc.gov/nchs/data/series/sr_02/

sr02_179.pdf. 
NCHS Data Brief ■ No. 394 ■ December 2020

Keywords: opioids • fentanyl • heroin • cocaine • methamphetamine • 

National Vital Statistics System Mortality File

Suggested citation

Hedegaard H, Miniño AM, Warner M. 

Drug overdose deaths in the United States, 

1999–2019. NCHS Data Brief, no 394. 

Hyattsville, MD: National Center for Health 

Statistics. 2020.

Copyright information

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the public domain and may be reproduced 

or copied without permission; citation as to 

source, however, is appreciated.

National Center for Health 

Statistics

Brian C. Moyer, Ph.D., Director

Amy M. Branum, Ph.D., Acting Associate 

Director for Science

Division of Analysis and Epidemiology

Irma E. Arispe, Ph.D., Director

Kevin C. Heslin, Ph.D., Associate Director for 

Science

Division of Vital Statistics

Steven Schwartz, Ph.D., Director

Isabelle Horon, Dr.P.H., Acting Associate Director 

for Science

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