| **CONSOLIDATED STATEMENTS OF OPERATIONS (Unaudited) (USD $)In Thousands, except Per Share data, unless otherwise specified** | 3 Months Ended | 6 Months Ended |
|------------------------------------------------------------------------------------------------------------------------------|----------------|----------------|
||
| **Revenues:**                                                                                                                |           |           |   |   |
| Royalty income                                                                                                               | $ 1,367        | $ 1,176        | $ 2,102 | $ 2,333 |
| Collaboration revenue                                                                                                        | 72             | 514            | 1,121 | 1,367 |
| Research grants                                                                                                              | 0              | 77             | 0 | 275 |
| Other revenues                                                                                                               | 38             | 34             | 69 | 52 |
| Total revenues                                                                                                               | 1,477          | 1,801          | 3,292 | 4,027 |
| **Expenses:**                                                                                                                |           |           |   |   |
| Research and development                                                                                                     | 7,848          | 9,585          | 14,767 | 18,300 |
| License fees - research and development                                                                                      | 180            | 153            | 270 | 223 |
| Royalty expense                                                                                                              | 147            | 119            | 229 | 235 |
| General and administrative                                                                                                   | 4,256          | 3,899          | 8,161 | 8,219 |
| Depreciation and amortization                                                                                                | 133            | 318            | 277 | 595 |
| Total expenses                                                                                                               | 12,564         | 14,074         | 23,704 | 27,572 |
| Operating loss                                                                                                               | (11,087)       | (12,273)       | (20,412) | (23,545) |
| **Other income:**                                                                                                            |           |           |   |   |
| Interest income                                                                                                              | 13             | 10             | 25 | 24 |
| Total other income                                                                                                           | 13             | 10             | 25 | 24 |
| Net loss before income tax benefit                                                                                           | (11,074)       | (12,263)       | (20,387) | (23,521) |
| Income tax benefit                                                                                                           | 1              | 0              | 1 | 0 |
| Net loss                                                                                                                     | $ (11,073)     | $ (12,263)     | $ (20,386) | $ (23,521) |
| Net loss per share - basic and diluted                                                                                       | $ (0.17)       | $ (0.24)       | $ (0.31) | $ (0.46) |
| Weighted-average shares - basic and diluted                                                                                  | 63,743         | 51,481         | 66,775 | 50,802 |

| X                                                                                                                                                                                                                                                                                                                                                                                        |
|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
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The amount of compensation earned (contract income) under a research and development arrangement accounted for as a contract to perform research and development for others.
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| - Definition
Revenue earned during the period from non-repayable sum of money awarded to an entity to carry out a specific purpose as provided in grant agreements, combined with the revenue earned during the period arising from products sold or services provided under the terms of a contract, not elsewhere specified in the taxonomy. May include government contracts, construction contracts, and any other contract related to a particular project or product.
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| - Definition
The aggregate expense recognized in the current period that allocates the cost of tangible assets, intangible assets, or depleting assets to periods that benefit from use of the assets.
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| - Definition
The amount of net income (loss) for the period per each share of common stock or unit outstanding during the reporting period.
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| - Definition
The aggregate total of expenses of managing and administering the affairs of an entity, including affiliates of the reporting entity, which are not directly or indirectly associated with the manufacture, sale or creation of a product or product line.
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| - Definition
This element represents the income or loss from continuing operations attributable to the economic entity which may also be defined as revenue less expenses from ongoing operations, after income or loss from equity method investments, but before income taxes, extraordinary items, and noncontrolling interest.
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Amount of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations.
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| - Definition
Amount before accretion (amortization) of purchase discount (premium) of interest income on nonoperating securities.
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| - Definition
Costs incurred and are directly related to generating license revenue. Licensing arrangements include, but are not limited to, rights to use a patent, copyright, technology, manufacturing process, software or trademark.
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| - Definition
The portion of profit or loss for the period, net of income taxes, which is attributable to the parent.
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| - Definition
The aggregate amount of income or expense from ancillary business-related activities (that is to say, excluding major activities considered part of the normal operations of the business).
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| - Definition
Generally recurring costs associated with normal operations except for the portion of these expenses which can be clearly related to production and included in cost of sales or services. Includes selling, general and administrative expense.
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The net result for the period of deducting operating expenses from operating revenues.
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Revenues from the sale of other goods or rendering of other services, not elsewhere specified in the taxonomy; net of (reduced by) sales adjustments, returns, allowances, and discounts.
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| - Definition
The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.
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Amount of revenue recognized from goods sold, services rendered, insurance premiums, or other activities that constitute an earning process. Includes, but is not limited to, investment and interest income before deduction of interest expense when recognized as a component of revenue, and sales and trading gain (loss).
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| - Definition
Amount of expense related to royalty payments under a contractual arrangement such as payment for mineral and drilling rights and use of technology or intellectual property.
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| - Definition
Revenue earned during the period from the leasing or otherwise lending to a third party the entity's rights or title to certain property. Royalty revenue is derived from a percentage or stated amount of sales proceeds or revenue generated by the third party using the entity's property. Examples of property from which royalties may be derived include patents and oil and mineral rights.
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| - Definition
Number of [basic] shares or units, after adjustment for contingently issuable shares or units and other shares or units not deemed outstanding, determined by relating the portion of time within a reporting period that common shares or units have been outstanding to the total time in that period.
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