### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] You are here: EPA Home Prevention, Pesticides & Toxic Substances Pollution Prevention & Toxics High Production Volume (HPV) Challenge High Production Volume Information System (HPVIS) Submission Report 

# High Production Volume Information System (HPVIS)

Contact Us 

### Search: All EPA This Area


# Submission Report

Submission Information
Submission ID : 25349542 Submission Name : 2H-3,1-Benzoxazine-2,41H-dione AR Number :


## Chemical Information
CAS Number : 118-48-9 Ninth Collective Index Name : 2H-3,1-Benzoxazine-2,4(1H)-dione



## Submitter Information
Submitter's Name : EPA Address : City : Washington State : DC ZIP/Postal Code : Country : Type of Submitter : Company 

## Technical Point of Contact Information
Technical Point of Contact : Title : Phone Number : Fax Number : E-Mail Address : 

## Additional Technical Point of Contact Information
Technical Point of Contact : Title : Phone Number : Fax Number : E-Mail Address : 

## Sponsor Information Sponsor's Name : EPA Address : City : State : ZIP/Postal Code : Country : Phone Number : Fax Number :

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] E-Mail Address : Type of Sponsor : Company 

## Technical Point of Contact Information
Technical Point of Contact : Title : Phone Number : Fax Number : E-Mail Address :



## Acute Toxicity to Aquatic Vertebrates

CAS Number : 118-48-9

Sponsored Chemical Name : 2H-3,1-Benzoxazine-2,4(1H)-dione


### Test Substance - Acute Toxicity To Aquatic Vertebrates
Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance Purity/Composition and Other Test Substance Comments: None

Sponsored Chemical Result Type: Measured

Test Substance Result Type: Measured


### Method - Acute Toxicity To Aquatic Vertebrates Year Study Performed: 1982

Method/Guideline Followed: Other

Other Method/Guideline: DIN 38412, Teil 15

Deviations from Method/Guideline: No Data
Species: Leuciscus idus

GLP: No
Analytical Monitoring: Yes
Test Type: Static

Test Vessel: No Data
Water Media Type: Freshwater

Test Concentrations: No Data

Nominal and Measured Concentrations: Exposure Period: 96 Hours

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] Vehicle Used: No Data

Vehicle Name: No Data

Vehicle Amount and Units: Alkalinity:

Dissolved Oxygen:

pH Value:

Test Temperature and Units:
Photo (Light/Dark): Salinity:

TOC:

Water Hardness:

Method/Guideline Test Conditions Remarks: Method/guideline followed: Bestimmung der Wirkung von Wasserinhaltsstoffen suf Fische, DIN 38412, Teil 15
Limit Test: Unknown


### Test Results - Acute Toxicity To Aquatic Vertebrates NOEC Exposure Duration: 96 Hours

NOEC: = 22 mg/L Unknown

LOEC Exposure Duration:
LOEC:

NOELR Exposure Duration:
NOELR:

LOELR Exposure Duration:
LOELR:

LC/EC Mean Value : Exposure Duration Exposure Units LC/EC % Value Description Mean Value

or Lower Mean Value Upper Mean Value Units Effect Observed Basis for Concentration

96 Hours LC 50 % = 46 100 mg/L Mortality Unknown

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] Results Remarks:


### Reliability/Data Quality - Acute Toxicity To Aquatic Vertebrates Reliability: 3 - Not Valid

Reliability Remarks: Key Study Sponsor Indicator: 

### Reference - Acute Toxicity To Aquatic Vertebrates
Reference: IUCLID dataset



## Acute Toxicity to Aquatic Invertebrates

CAS Number : 118-48-9

Sponsored Chemical Name : 2H-3,1-Benzoxazine-2,4(1H)-dione


### Test Substance - Acute Toxicity To Aquatic Invertebrates
Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance Purity/Composition and Other Test Substance Comments: None

Sponsored Chemical Result Type: Measured

Test Substance Result Type: Nominal


### Method - Acute Toxicity To Aquatic Invertebrates Year Study Performed: 1988

Method/Guideline Followed: EU C.2 (84/449/EEC)

Other Method/Guideline:
Deviations from Method/Guideline: No Data
Species/In Vitro System: Daphnia magna

GLP: No
Analytical Monitoring: No
Test Type: Static

Test Vessel: No Data

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] Water Media Type: Freshwater

Test Concentrations: No Data

Nominal and Measured Concentrations: Exposure Period: 48 Hours

Vehicle Used:

Vehicle Name:

Vehicle Amount and Units: Alkalinity:

Dissolved Oxygen:

pH Value:

Test Temperature and Units:
Photo (Light/Dark): Salinity:

TOC:

Water Hardness:

Method/Guideline Test Conditions Remarks:
Limit Test:


### Test Results - Acute Toxicity To Aquatic Invertebrates NOEC Exposure Duration:
NOEC:

LOEC Exposure Duration:
LOEC:

NOELR Exposure Duration:
NOELR:

LOELR Exposure Duration:
LOELR:

LC/EC Mean Value : Exposure Duration Exposure Units LC/EC % Value Description Mean Value

or Upper Mean Value Units Effect Observed Basis for Concentration

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] Lower Mean Value 48 Hours EC 50 % = 86 mg/L Mortality Unknown

48 Hours EC 100 % = 125 mg/L Mortality Unknown

48 Hours EC 0 % = 62.5 mg/L Mortality Unknown

Results Remarks:


### Reliability/Data Quality - Acute Toxicity To Aquatic Invertebrates Reliability: 2 - Valid With Restrictions

Reliability Remarks: Key Study Sponsor Indicator: 

### Reference - Acute Toxicity To Aquatic Invertebrates
Reference: IUCLID dataset



## Acute Toxicity to Aquatic Invertebrates

CAS Number : 118-48-9

Sponsored Chemical Name : 2H-3,1-Benzoxazine-2,4(1H)-dione


### Test Substance - Acute Toxicity To Aquatic Invertebrates
Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance Purity/Composition and Other Test Substance Comments: None

Sponsored Chemical Result Type: Measured

Test Substance Result Type: Nominal


### Method - Acute Toxicity To Aquatic Invertebrates Year Study Performed: 1988

Method/Guideline Followed: EU C.2 (84/449/EEC)

Other Method/Guideline:
Deviations from Method/Guideline: No Data
Species/In Vitro System: Daphnia magna

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] GLP: No
Analytical Monitoring: No
Test Type: Static

Test Vessel: No Data
Water Media Type: Freshwater

Test Concentrations: No Data

Nominal and Measured Concentrations: Exposure Period: 24 Hours

Vehicle Used:

Vehicle Name:

Vehicle Amount and Units: Alkalinity:

Dissolved Oxygen:

pH Value:

Test Temperature and Units:
Photo (Light/Dark): Salinity:

TOC:

Water Hardness:

Method/Guideline Test Conditions Remarks:
Limit Test:


### Test Results - Acute Toxicity To Aquatic Invertebrates NOEC Exposure Duration:
NOEC:

LOEC Exposure Duration:
LOEC:

NOELR Exposure Duration:
NOELR:

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] LOELR Exposure Duration:
LOELR:

LC/EC Mean Value : Exposure Duration Exposure Units LC/EC % Value Description Mean Value

or Lower Mean Value Upper Mean Value Units Effect Observed Basis for Concentration

24 Hours EC 50 % = 110 mg/L Mortality Unknown

24 Hours EC 100 % = 250 mg/L Mortality Unknown

Results Remarks:


### Reliability/Data Quality - Acute Toxicity To Aquatic Invertebrates Reliability: 2 - Valid With Restrictions

Reliability Remarks: Key Study Sponsor Indicator: 

### Reference - Acute Toxicity To Aquatic Invertebrates
Reference: IUCLID dataset



## Acute Toxicity to Aquatic Plants

CAS Number : 118-48-9

Sponsored Chemical Name : 2H-3,1-Benzoxazine-2,4(1H)-dione


### Test Substance - Acute Toxicity To Aquatic Plants
Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance Purity/Composition and Other Test Substance Comments: Sponsored Chemical Result Type: Measured

Test Substance Result Type: Nominal


### Method - Acute Toxicity To Aquatic Plants Year Study Performed: 1988

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] Method/Guideline Followed: Other

Other Method/Guideline: Scenedesmus-Zellvermehrungs-Hemmtest, DIN 38412 Teil 9, Bestimmung der Hemmwirkung von Wasserinhaltsstoffen auf Gruenalgen
Deviations from Method/Guideline: No Data
Species: Scenedesmus subspicatus

GLP: No
Analytical Monitoring: No
Test Type: Static

Test Vessel: No Data
Water Media Type: Freshwater

Test Concentrations:
Nominal and Measured Concentrations: Exposure Period: 72 Hours

Vehicle Used:

Vehicle Name:

Vehicle Amount and Units: Alkalinity:

Dissolved Oxygen:

pH Value:

Test Temperature and Units:
Photo (Light/Dark): Salinity:

TOC:

Water Hardness:

Method/Guideline Test Conditions Remarks:
Limit Test:


### Test Results - Acute Toxicity To Aquatic Plants NOEC Exposure Duration:

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] NOEC:

LOEC Exposure Duration:
LOEC:

NOELR Exposure Duration:
NOELR:

LOELR Exposure Duration:
LOELR:

Effect : Exposure Duration Exposure Units Type % Value Description Mean Value

or Lower Mean Value Upper Mean Value Units Basis for Effect Basis for Concentration

72 Hours EC 50 % = 14.5 mg/L No Data Unknown

72 Hours EC 90 % = 34.9 mg/L No Data Unknown

72 Hours EC 10 % = 5 mg/L No Data Unknown

Results Remarks:


### Reliability/Data Quality - Acute Toxicity To Aquatic Plants Reliability: 3 - Not Valid

Reliability Remarks: Key Study Sponsor Indicator: 

### Reference - Acute Toxicity To Aquatic Plants
Reference: IUCLID dataset



## Acute Toxicity to Aquatic Plants

CAS Number : 118-48-9

Sponsored Chemical Name : 2H-3,1-Benzoxazine-2,4(1H)-dione


### Test Substance - Acute Toxicity To Aquatic Plants
Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance Purity/Composition and Other Test Substance Comments:

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] Sponsored Chemical Result Type: Measured

Test Substance Result Type: Nominal


### Method - Acute Toxicity To Aquatic Plants Year Study Performed: 1988

Method/Guideline Followed: Other

Other Method/Guideline: Scenedesmus-Zellvermehrungs-Hemmtest, DIN 38412 Teil 9, Bestimmung der Hemmwirkung von Wasserinhaltsstoffen auf Gruenalgen
Deviations from Method/Guideline: No Data
Species: Scenedesmus subspicatus

GLP: No
Analytical Monitoring: No
Test Type: Static

Test Vessel: No Data
Water Media Type: Freshwater

Test Concentrations:
Nominal and Measured Concentrations: Exposure Period: 96 Hours

Vehicle Used:

Vehicle Name:

Vehicle Amount and Units: Alkalinity:

Dissolved Oxygen:

pH Value:

Test Temperature and Units:
Photo (Light/Dark): Salinity:

TOC:

Water Hardness:

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] Method/Guideline Test Conditions Remarks:
Limit Test:


### Test Results - Acute Toxicity To Aquatic Plants NOEC Exposure Duration:
NOEC:

LOEC Exposure Duration:
LOEC:

NOELR Exposure Duration:
NOELR:

LOELR Exposure Duration:
LOELR:

Effect : Exposure Duration Exposure Units Type % Value Description Mean Value

or Lower Mean Value Upper Mean Value Units Basis for Effect Basis for Concentration

96 Hours EC 50 % = 16 mg/L No Data Unknown

96 Hours EC 90 % = 36.9 mg/L No Data Unknown

96 Hours EC 10 % = 4.5 mg/L No Data Unknown

Results Remarks:


### Reliability/Data Quality - Acute Toxicity To Aquatic Plants Reliability: 3 - Not Valid

Reliability Remarks: Key Study Sponsor Indicator: 

### Reference - Acute Toxicity To Aquatic Plants
Reference: IUCLID dataset



## Acute Toxicity

CAS Number : 118-48-9

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] Sponsored Chemical Name : 2H-3,1-Benzoxazine-2,4(1H)-dione


### Test Substance - Acute Toxicity
Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance Purity/Composition and Other Test Substance Comments: Sponsored Chemical Result Type: Measured


### Method - Acute Toxicity
Route of Administration: Oral
Type of Exposure: No Data
Species: Guinea pig

Mammalian Strain: No Data

Gender:

Number of Animals per Dose:
Dose:

Year Study Performed:

Method/Guideline Followed: Other

GLP:

Method/Guideline and Test Condition Remarks: 

### Test Results - Acute Toxicity Concentration (LC/LD) : LC/LD % Value Description Value/Lower Concentration Upper Concentration Units

LD 50 % circa 500 mg/kgbw

Number of Deaths ( Male ): Number of Deaths ( Female ): Number of Deaths ( Total ):
Results Remarks:

Conclusion:

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] Reliability/Data Quality - Acute Toxicity Reliability: 3 - Not Valid

Reliability Remarks: Summary is in German

Key Study Sponsor Indicator: 

### Reference - Acute Toxicity
Reference: IUCLID dataset



## Acute Toxicity

CAS Number : 118-48-9

Sponsored Chemical Name : 2H-3,1-Benzoxazine-2,4(1H)-dione


### Test Substance - Acute Toxicity
Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance Purity/Composition and Other Test Substance Comments: Sponsored Chemical Result Type: Measured


### Method - Acute Toxicity
Route of Administration: Inhalation

Type of Exposure: No Data
Species: Rat

Mammalian Strain: No Data

Gender:

Number of Animals per Dose:
Concentration:

Year Study Performed:

Method/Guideline Followed: Other

GLP:

Method/Guideline and Test Condition Remarks: exposure duration: 1 hour


### Test Results - Acute Toxicity Concentration (LC/LD) : LC/LD % Value Value/Lower Upper Units

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] Description Concentration Concentration LC 50 % = 192 mg/L

Number of Deaths ( Male ): Number of Deaths ( Female ): Number of Deaths ( Total ):
Results Remarks:

Conclusion:


### Reliability/Data Quality - Acute Toxicity Reliability: 3 - Not Valid

Reliability Remarks:

Key Study Sponsor Indicator: 

### Reference - Acute Toxicity
Reference: IUCLID dataset



## Acute Toxicity

CAS Number : 118-48-9

Sponsored Chemical Name : 2H-3,1-Benzoxazine-2,4(1H)-dione


### Test Substance - Acute Toxicity
Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance Purity/Composition and Other Test Substance Comments: Sponsored Chemical Result Type: Measured


### Method - Acute Toxicity
Route of Administration: Inhalation

Type of Exposure: Aerosol

Species: Mouse

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] Mammalian Strain: No Data

Gender:

Number of Animals per Dose:
Concentration:

Year Study Performed: 1963

Method/Guideline Followed: Other

GLP: No Data

Method/Guideline and Test Condition Remarks: exposure duration: 4 hours method: dynamische Inhalation nach Niessen et al.: Arch. Toxicol. 20, 44



### Test Results - Acute Toxicity Concentration (LC/LD) : LC/LD % Value Description Value/Lower Concentration Upper Concentration Units

LC 50 % > 0.378 mg/L

Number of Deaths ( Male ): Number of Deaths ( Female ): Number of Deaths ( Total ):
Results Remarks:

Conclusion:


### Reliability/Data Quality - Acute Toxicity Reliability: 3 - Not Valid

Reliability Remarks: Summary is in German

Key Study Sponsor Indicator: 

### Reference - Acute Toxicity
Reference: IUCLID dataset



## Acute Toxicity

CAS Number : 118-48-9

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] Sponsored Chemical Name : 2H-3,1-Benzoxazine-2,4(1H)-dione


### Test Substance - Acute Toxicity
Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance Purity/Composition and Other Test Substance Comments: Sponsored Chemical Result Type: Measured


### Method - Acute Toxicity
Route of Administration: Oral
Type of Exposure: No Data
Species: Rat

Mammalian Strain: No Data

Gender:

Number of Animals per Dose:
Dose:

Year Study Performed:

Method/Guideline Followed:
GLP:

Method/Guideline and Test Condition Remarks: 

### Test Results - Acute Toxicity Concentration (LC/LD) : LC/LD % Value Description Value/Lower Concentration Upper Concentration Units

LD 50 % > 5000 mg/kgbw

Number of Deaths ( Male ): Number of Deaths ( Female ): Number of Deaths ( Total ):
Results Remarks:

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] Conclusion:


### Reliability/Data Quality - Acute Toxicity Reliability: 3 - Not Valid

Reliability Remarks:

Key Study Sponsor Indicator: 

### Reference - Acute Toxicity
Reference: IUCLID dataset



## Acute Toxicity

CAS Number : 118-48-9

Sponsored Chemical Name : 2H-3,1-Benzoxazine-2,4(1H)-dione


### Test Substance - Acute Toxicity
Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance Purity/Composition and Other Test Substance Comments: Sponsored Chemical Result Type: Measured


### Method - Acute Toxicity
Route of Administration: Inhalation

Type of Exposure: No Data
Species: Rat

Mammalian Strain: No Data

Gender:

Number of Animals per Dose:
Concentration:

Year Study Performed:

Method/Guideline Followed: Other

GLP: No Data

Method/Guideline and Test Condition Remarks: exposure duration: 8 hours method: BASF Test



### Test Results - Acute Toxicity

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] Concentration (LC/LD) : LC/LD % Value Description Value/Lower Concentration Upper Concentration Units

Number of Deaths ( Male ): Number of Deaths ( Female ): Number of Deaths ( Total ):
Results Remarks:

Conclusion:


### Reliability/Data Quality - Acute Toxicity Reliability: 3 - Not Valid

Reliability Remarks: Summary is in German

Key Study Sponsor Indicator: 

### Reference - Acute Toxicity
Reference: IUCLID dataset



## Acute Toxicity

CAS Number : 118-48-9

Sponsored Chemical Name : 2H-3,1-Benzoxazine-2,4(1H)-dione


### Test Substance - Acute Toxicity
Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance Purity/Composition and Other Test Substance Comments: Sponsored Chemical Result Type: Measured


### Method - Acute Toxicity
Route of Administration: Oral
Type of Exposure: No Data
Species: Rat

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] Mammalian Strain: No Data

Gender:

Number of Animals per Dose:
Dose:

Year Study Performed:

Method/Guideline Followed: Other

GLP:

Method/Guideline and Test Condition Remarks: 

### Test Results - Acute Toxicity Concentration (LC/LD) : LC/LD % Value Description Value/Lower Concentration Upper Concentration Units

LD 50 % > 2500 mg/kgbw

Number of Deaths ( Male ): Number of Deaths ( Female ): Number of Deaths ( Total ):
Results Remarks:

Conclusion:


### Reliability/Data Quality - Acute Toxicity Reliability: 3 - Not Valid

Reliability Remarks: Summary is in German.

Key Study Sponsor Indicator: 

### Reference - Acute Toxicity
Reference: IUCLID dataset



## Acute Toxicity

CAS Number : 118-48-9

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] Sponsored Chemical Name : 2H-3,1-Benzoxazine-2,4(1H)-dione


### Test Substance - Acute Toxicity
Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance Purity/Composition and Other Test Substance Comments: Sponsored Chemical Result Type: Measured


### Method - Acute Toxicity
Route of Administration: Oral
Type of Exposure: No Data
Species: Cat

Mammalian Strain: No Data

Gender:

Number of Animals per Dose:
Dose:

Year Study Performed:

Method/Guideline Followed: Other

GLP:

Method/Guideline and Test Condition Remarks: 

### Test Results - Acute Toxicity Concentration (LC/LD) : LC/LD % Value Description Value/Lower Concentration Upper Concentration Units

LD 50 % > 500 mg/kgbw

Number of Deaths ( Male ): Number of Deaths ( Female ): Number of Deaths ( Total ):
Results Remarks:

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] Conclusion:


### Reliability/Data Quality - Acute Toxicity Reliability: 3 - Not Valid

Reliability Remarks: Summary is in German

Key Study Sponsor Indicator: 

### Reference - Acute Toxicity
Reference: IUCLID dataset



## Acute Toxicity

CAS Number : 118-48-9

Sponsored Chemical Name : 2H-3,1-Benzoxazine-2,4(1H)-dione


### Test Substance - Acute Toxicity
Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance Purity/Composition and Other Test Substance Comments: Sponsored Chemical Result Type: Measured


### Method - Acute Toxicity
Route of Administration: Oral
Type of Exposure: No Data
Species: Mouse

Mammalian Strain: No Data

Gender:

Number of Animals per Dose:
Dose:

Year Study Performed:

Method/Guideline Followed: Other

GLP:

Method/Guideline and Test Condition Remarks: 

### Test Results - Acute Toxicity

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] Concentration (LC/LD) : LC/LD % Value Description Value/Lower Concentration Upper Concentration Units

LD 50 % = 250 mg/kgbw

Number of Deaths ( Male ): Number of Deaths ( Female ): Number of Deaths ( Total ):
Results Remarks:

Conclusion:


### Reliability/Data Quality - Acute Toxicity Reliability: 3 - Not Valid

Reliability Remarks:

Key Study Sponsor Indicator: 

### Reference - Acute Toxicity
Reference: IUCLID dataset



## Acute Toxicity

CAS Number : 118-48-9

Sponsored Chemical Name : 2H-3,1-Benzoxazine-2,4(1H)-dione


### Test Substance - Acute Toxicity
Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance Purity/Composition and Other Test Substance Comments: Sponsored Chemical Result Type: Measured


### Method - Acute Toxicity
Route of Administration: Dermal
Type of Exposure: No Data
Species: Rabbit

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] Mammalian Strain: No Data

Gender:

Number of Animals per Dose:
Dose:

Year Study Performed:

Method/Guideline Followed: Other

GLP: No Data

Method/Guideline and Test Condition Remarks: 

### Test Results - Acute Toxicity Concentration (LC/LD) : LC/LD % Value Description Value/Lower Concentration Upper Concentration Units

LD 50 % > 2000 mg/kgbw

Number of Deaths ( Male ): Number of Deaths ( Female ): Number of Deaths ( Total ):
Results Remarks:

Conclusion:


### Reliability/Data Quality - Acute Toxicity Reliability: 3 - Not Valid

Reliability Remarks:

Key Study Sponsor Indicator: 

### Reference - Acute Toxicity
Reference: IUCLID dataset



## Acute Toxicity

CAS Number : 118-48-9

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] Sponsored Chemical Name : 2H-3,1-Benzoxazine-2,4(1H)-dione


### Test Substance - Acute Toxicity
Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance Purity/Composition and Other Test Substance Comments: Sponsored Chemical Result Type: Measured


### Method - Acute Toxicity
Route of Administration: Inhalation

Type of Exposure: No Data
Species: Rat

Mammalian Strain: No Data

Gender:

Number of Animals per Dose:
Concentration:

Year Study Performed: 1963

Method/Guideline Followed: Other

GLP: Not Applicable

Method/Guideline and Test Condition Remarks: exposure duration: 4 hours method: dynamische Inhalation nach Niessen et al.: Arch. Toxicol. 20, 44



### Test Results - Acute Toxicity Concentration (LC/LD) : LC/LD % Value Description Value/Lower Concentration Upper Concentration Units

LC 50 % > 0.348 mg/L

Number of Deaths ( Male ): Number of Deaths ( Female ): Number of Deaths ( Total ):
Results Remarks:

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] Conclusion:


### Reliability/Data Quality - Acute Toxicity Reliability: 3 - Not Valid

Reliability Remarks: Summary is in German

Key Study Sponsor Indicator: 

### Reference - Acute Toxicity
Reference: IUCLID dataset



## Acute Toxicity

CAS Number : 118-48-9

Sponsored Chemical Name : 2H-3,1-Benzoxazine-2,4(1H)-dione


### Test Substance - Acute Toxicity
Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance Purity/Composition and Other Test Substance Comments: Sponsored Chemical Result Type: Measured


### Method - Acute Toxicity
Route of Administration: Inhalation

Type of Exposure: No Data
Species: Rat

Mammalian Strain: No Data

Gender:

Number of Animals per Dose:
Concentration:

Year Study Performed: 1981

Method/Guideline Followed: OECD 403

GLP: No

Method/Guideline and Test Condition Remarks: exposure duration: 4 hours


### Test Results - Acute Toxicity

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] Concentration (LC/LD) : LC/LD % Value Description Value/Lower Concentration Upper Concentration Units

LC 50 % > 5.3 mg/L

Number of Deaths ( Male ): Number of Deaths ( Female ): Number of Deaths ( Total ):
Results Remarks:

Conclusion:


### Reliability/Data Quality - Acute Toxicity Reliability: 3 - Not Valid

Reliability Remarks: Summary is in German

Key Study Sponsor Indicator: 

### Reference - Acute Toxicity
Reference: IUCLID dataset



## Acute Toxicity

CAS Number : 118-48-9

Sponsored Chemical Name : 2H-3,1-Benzoxazine-2,4(1H)-dione


### Test Substance - Acute Toxicity
Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance Purity/Composition and Other Test Substance Comments: Sponsored Chemical Result Type: Measured


### Method - Acute Toxicity
Route of Administration: Oral
Type of Exposure: No Data

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] Species: Hen

Mammalian Strain: No Data

Gender:

Number of Animals per Dose:
Dose:

Year Study Performed:

Method/Guideline Followed: Other

GLP:

Method/Guideline and Test Condition Remarks: 

### Test Results - Acute Toxicity Concentration (LC/LD) : LC/LD % Value Description Value/Lower Concentration Upper Concentration Units

LD 50 % > 2500 mg/kgbw

Number of Deaths ( Male ): Number of Deaths ( Female ): Number of Deaths ( Total ):
Results Remarks:

Conclusion:


### Reliability/Data Quality - Acute Toxicity Reliability: 3 - Not Valid

Reliability Remarks: Summary is in German

Key Study Sponsor Indicator: 

### Reference - Acute Toxicity
Reference: IUCLID dataset



## Acute Toxicity

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] CAS Number : 118-48-9

Sponsored Chemical Name : 2H-3,1-Benzoxazine-2,4(1H)-dione


### Test Substance - Acute Toxicity
Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance Purity/Composition and Other Test Substance Comments: Sponsored Chemical Result Type: Measured


### Method - Acute Toxicity
Route of Administration: Oral
Type of Exposure: No Data
Species: Mouse

Mammalian Strain: No Data

Gender:

Number of Animals per Dose:
Dose:

Year Study Performed:

Method/Guideline Followed: Other

GLP:

Method/Guideline and Test Condition Remarks: 

### Test Results - Acute Toxicity Concentration (LC/LD) : LC/LD % Value Description Value/Lower Concentration Upper Concentration Units

LD 50 % > 1000 mg/kgbw

Number of Deaths ( Male ): Number of Deaths ( Female ): Number of Deaths ( Total ):

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] Results Remarks:

Conclusion:


### Reliability/Data Quality - Acute Toxicity Reliability: 3 - Not Valid

Reliability Remarks: Summary is in German.

Key Study Sponsor Indicator: 

### Reference - Acute Toxicity
Reference: IUCLID dataset



## Acute Toxicity

CAS Number : 118-48-9

Sponsored Chemical Name : 2H-3,1-Benzoxazine-2,4(1H)-dione


### Test Substance - Acute Toxicity
Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance Purity/Composition and Other Test Substance Comments: Sponsored Chemical Result Type: Measured


### Method - Acute Toxicity
Route of Administration: Inhalation

Type of Exposure: No Data
Species: Rat

Mammalian Strain: No Data

Gender:

Number of Animals per Dose:
Concentration:

Year Study Performed: 1963

Method/Guideline Followed: Other

GLP: Not Applicable

Method/Guideline and Test Condition Remarks: exposure duration: 4 hours method: dynamische Inhalation nach Niessen et al.: Arch.

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] Toxicol. 20, 44



### Test Results - Acute Toxicity Concentration (LC/LD) : LC/LD % Value Description Value/Lower Concentration Upper Concentration Units

LC 50 % > 0.255 mg/L

Number of Deaths ( Male ): Number of Deaths ( Female ): Number of Deaths ( Total ):
Results Remarks:

Conclusion:


### Reliability/Data Quality - Acute Toxicity Reliability: 3 - Not Valid

Reliability Remarks: Summary is in German

Key Study Sponsor Indicator: 

### Reference - Acute Toxicity
Reference: IUCLID dataset



## Acute Toxicity

CAS Number : 118-48-9

Sponsored Chemical Name : 2H-3,1-Benzoxazine-2,4(1H)-dione


### Test Substance - Acute Toxicity
Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance Purity/Composition and Other Test Substance Comments: Sponsored Chemical Result Type: Measured


### Method - Acute Toxicity
Route of Administration: Oral

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] Type of Exposure: No Data
Species: Rat

Mammalian Strain: No Data

Gender:

Number of Animals per Dose:
Dose:

Year Study Performed:

Method/Guideline Followed: Other

GLP:

Method/Guideline and Test Condition Remarks: BASF Test


### Test Results - Acute Toxicity Concentration (LC/LD) : LC/LD % Value Description Value/Lower Concentration Upper Concentration Units

LD 50 % > 6400 mg/kgbw

Number of Deaths ( Male ): Number of Deaths ( Female ): Number of Deaths ( Total ):
Results Remarks:

Conclusion:


### Reliability/Data Quality - Acute Toxicity Reliability: 3 - Not Valid

Reliability Remarks: Summary is in German.

Key Study Sponsor Indicator: 

### Reference - Acute Toxicity
Reference: IUCLID dataset

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] 

## Acute Toxicity

CAS Number : 118-48-9

Sponsored Chemical Name : 2H-3,1-Benzoxazine-2,4(1H)-dione


### Test Substance - Acute Toxicity
Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance Purity/Composition and Other Test Substance Comments: Sponsored Chemical Result Type: Measured


### Method - Acute Toxicity
Route of Administration: Inhalation

Type of Exposure: Aerosol

Species: No data

Mammalian Strain: No Data

Gender:

Number of Animals per Dose:
Concentration:

Year Study Performed:

Method/Guideline Followed: Other

GLP: No Data

Method/Guideline and Test Condition Remarks: exposure duration: 4 hours Aerosol was tested.



### Test Results - Acute Toxicity Concentration (LC/LD) : LC/LD % Value Description Value/Lower Concentration Upper Concentration Units

Number of Deaths ( Male ): Number of Deaths ( Female ):

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] Number of Deaths ( Total ):
Results Remarks:

Conclusion:


### Reliability/Data Quality - Acute Toxicity Reliability: 3 - Not Valid

Reliability Remarks: Summary is in German

Key Study Sponsor Indicator: 

### Reference - Acute Toxicity
Reference: IUCLID dataset



## Acute Toxicity

CAS Number : 118-48-9

Sponsored Chemical Name : 2H-3,1-Benzoxazine-2,4(1H)-dione


### Test Substance - Acute Toxicity
Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance Purity/Composition and Other Test Substance Comments: Sponsored Chemical Result Type: Measured


### Method - Acute Toxicity
Route of Administration: Dermal
Type of Exposure: No Data
Species: Rat

Mammalian Strain: No Data

Gender:

Number of Animals per Dose:
Dose:

Year Study Performed:

Method/Guideline Followed: Other

GLP: No Data

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] Method/Guideline and Test Condition Remarks: Method/guideline followed: offene Applikation, intakte Haut, 7 Tauge



### Test Results - Acute Toxicity Concentration (LC/LD) : LC/LD % Value Description Value/Lower Concentration Upper Concentration Units

LD 50 % > 500 mg/kgbw

Number of Deaths ( Male ): Number of Deaths ( Female ): Number of Deaths ( Total ):
Results Remarks:

Conclusion:


### Reliability/Data Quality - Acute Toxicity Reliability: 3 - Not Valid

Reliability Remarks: Summary is in German

Key Study Sponsor Indicator: 

### Reference - Acute Toxicity
Reference: IUCLID dataset



## Repeated-Dose Toxicity

CAS Number : 118-48-9

Sponsored Chemical Name : 2H-3,1-Benzoxazine-2,4(1H)-dione


### Test Substance - Repeated-Dose Toxicity
Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance Purity/Composition and Other Test Substance Comments: Sponsored Chemical Result Type: Measured


### Method - Repeated-Dose Toxicity

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] Route of Administration: Oral
Type of Exposure: No Data
Species: Rat

Mammalian Strain: Wistar

Gender: Male

Number of Animals per Dose:
Dose: 1000 mg/kg (max dose)
Year Study Performed: 1961

Method/Guideline Followed: Other

GLP: No
Exposure Period: 5 Days
Frequency of Treatment: daily

Post-Exposure Period: 6 Days

Method/Guideline and Test Condition Remarks: Method/guideline followed: in Anlehnung an Lim et al.: Arch. Int. Pharmacol. 130, 336
Control group and treatment: Not specified.
Post-observation period: 6-13 days

Statistical methods: Cannot ascertain - study is in German.

Method remarks: Remarks are in German.


### Test Results - Repeated-Dose Toxicity Concentration (LOAEL/ LOAEC/ NOAEL/ NOAEC) : LOAEL/ LOAEC/ NOAEL/ NOAEC Population Value Description Value/Lower Concentration Upper Concentration Units

Results Remarks:

Conclusion:


### Reliability/Data Quality - Repeated-Dose Toxicity Reliability: 3 - Not Valid

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] Reliability Remarks: Summary is in German

Key Study Sponsor Indicator: 

### Reference - Repeated-Dose Toxicity
Reference: IUCLID dataset



## Repeated-Dose Toxicity

CAS Number : 118-48-9

Sponsored Chemical Name : 2H-3,1-Benzoxazine-2,4(1H)-dione


### Test Substance - Repeated-Dose Toxicity
Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance Purity/Composition and Other Test Substance Comments: Sponsored Chemical Result Type: Measured


### Method - Repeated-Dose Toxicity
Route of Administration: Inhalation

Type of Exposure: Aerosol

Species: Rat

Mammalian Strain: Wistar

Gender: Both M/F

Number of Animals per Dose:
Concentration: 0.197 mg/L
Year Study Performed: 1963

Method/Guideline Followed: Other

GLP: No
Exposure Period: 5 Days
Frequency of Treatment: 4 hours a day

Post-Exposure Period: 2 Weeks

Method/Guideline and Test Condition Remarks: Statistical methods: Cannot ascertain - study is in German.

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] Method remarks: Remarks are in German.


### Test Results - Repeated-Dose Toxicity Concentration (LOAEL/ LOAEC/ NOAEL/ NOAEC) : LOAEL/ LOAEC/ NOAEL/ NOAEC Population Value Description Value/Lower Concentration Upper Concentration Units

Results Remarks: LC50 > 0.197 mg/L

Conclusion:


### Reliability/Data Quality - Repeated-Dose Toxicity Reliability: 3 - Not Valid

Reliability Remarks: Summary is in German

Key Study Sponsor Indicator: 

### Reference - Repeated-Dose Toxicity
Reference: IUCLID dataset



## Repeated-Dose Toxicity

CAS Number : 118-48-9

Sponsored Chemical Name : 2H-3,1-Benzoxazine-2,4(1H)-dione


### Test Substance - Repeated-Dose Toxicity
Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance Purity/Composition and Other Test Substance Comments: Sponsored Chemical Result Type: Measured


### Method - Repeated-Dose Toxicity
Route of Administration: Inhalation

Type of Exposure: Aerosol

Species: Rat

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] Mammalian Strain: Wistar

Gender: Both M/F

Number of Animals per Dose:
Concentration: 0.0116; 0.071 mg/L (DMSO and Lutol 1:1)
Year Study Performed: 1963

Method/Guideline Followed: Other

GLP: No
Exposure Period: 28 Days
Frequency of Treatment: 4 hours a day, 5 days a week over 28 days

Post-Exposure Period:

Method/Guideline and Test Condition Remarks: Method/guideline followed: dynamische Inhalation nach Niessen et al.: Arch. Toxicol. 20, 44 Control group and treatment: Yes, concurrent vehicle
Post-observation period: None

Statistical methods: Cannot ascertain - study is in German.

Method remarks: Remarks are in German.


### Test Results - Repeated-Dose Toxicity Concentration (LOAEL/ LOAEC/ NOAEL/ NOAEC) : LOAEL/ LOAEC/ NOAEL/ NOAEC Population Value Description Value/Lower Concentration Upper Concentration Units

NOAEC = 0.0116 mg/L

Results Remarks:

Conclusion:


### Reliability/Data Quality - Repeated-Dose Toxicity Reliability: 3 - Not Valid

Reliability Remarks: Summary is in German

Key Study Sponsor Indicator: 

### Reference - Repeated-Dose Toxicity

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] Reference: IUCLID dataset



## Genetic Toxicity in vivo

CAS Number : 118-48-9

Sponsored Chemical Name : 2H-3,1-Benzoxazine-2,4(1H)-dione


### Test Substance - Genetic Toxicity in vivo
Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance Purity/Composition and Other Test Substance Comments: Sponsored Chemical Result Type: Measured


### Method - Genetic Toxicity in vivo Type of Study: Bone Marrow Chromosomal Aberration

Type of Test: Micronucleus assay

Route of Administration: Oral
Type of Exposure: Gavage
Species: Mouse

Strain: NMRI

Gender: Both M/F

Dose: Test substance was administered at 200, 670, 2000 mg/kg (24 h preparation interval), 2000 mg/kg (48 hour preparation interval) Year Study Performed: 1983

Method/Guideline Followed: OECD 474

GLP: Yes

Duration of Treatment/ Exposure Period and Units: Frequency of Treatment:

Positive, Negative, and Solvent Control Substance(s): Number of Animals per Sex and Dose Group:
Method/Guideline and Test Condition Remarks: 

### Test Results - Genetic Toxicity in vivo

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] Systemic Toxicity: Unknown

Genotoxic Effect: Unknown

Results Remarks: Summary in German.

Conclusion:


### Reliability/Data Quality - Genetic Toxicity in vivo Reliability: 3 - Not Valid

Reliability Remarks:

Key Study Sponsor Indicator: 

### Reference - Genetic Toxicity in vivo
Reference: IUCLID dataset



## Genetic Toxicity in vitro

CAS Number : 118-48-9

Sponsored Chemical Name : 2H-3,1-Benzoxazine-2,4(1H)-dione


### Test Substance - Genetic Toxicity in vitro
Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance Purity/Composition and Other Test Substance Comments: Sponsored Chemical Result Type: Measured


### Method - Genetic Toxicity in vitro Type of Study: Bacterial reverse mutation assay

Concentrations: 20 μg - 5000 μg/plate
Year Study Performed: 1975

Method/Guideline Followed: Other

GLP: No
Postive, Negative, and Solvent Control Substance(s):
Method/Guideline and Test Condition Remarks: Method/guideline followed: in Anlehnung an: Ames B.N. et al.: Proc. Natl. Acad. Sci. USA 70, 2281- 2285, (1973) und Ames, B.N. et al.: Mut. Res. 31, 347-364, (1975)

Test system: Bacterial cell, in vitro Species/Strain/cell-type/cell line: Salmonella typhimurium TA1535,

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] TA100, TA1537, TA98

Metabolic activation: With and without
Concentrations tested: 20 μg - 5000 μg/plate Remarks: Standard test plate.



### Test Results - Genetic Toxicity in vitro Details on Cytogenetic Assay:
Statistics:

Effect : Species Other Species Strain Other Strain Metabolic Activation Genotoxic Effect Conclusion

Bacteria S. typhimurium

TA 1535 With and Without Negative

Bacteria S. typhimurium TA 100 With and Without Negative

Bacteria S. typhimurium

TA 1537 With and Without Negative

Bacteria S. typhimurium TA 98 With and Without Negative

Results Remarks: Negative

Conclusion:


### Reliability/Data Quality - Genetic Toxicity in vitro Reliability: 3 - Not Valid

Reliability Remarks:

Key Study Sponsor Indicator: 

### Reference - Genetic Toxicity in vitro
Reference: IUCLID dataset



## Reproductive Toxicity

CAS Number : 118-48-9

Sponsored Chemical Name : 2H-3,1-Benzoxazine-2,4(1H)-dione


### Test Substance - Reproductive Toxicity
Test Substance: (118-48-9) 2H-3,1-Benzoxazine-2,4(1H)-dione

Test Substance

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] Purity/Composition and Other Test Substance Comments: Sponsored Chemical Result Type: Measured


### Method - Reproductive Toxicity
Route of Administration: Subcutaneous
Type of Exposure:

Species: Mouse

Mammalian Strain: Swiss

Gender: Female

Number of Animals per Dose:
Dose: 4 mg, 8 mg
Year Study Performed:

Method/Guideline Followed: Other

GLP: No
Exposure Period: 5 - 6.5 Days
Frequency of Treatment: Post-Exposure Period:

Method/Guideline and Test Condition Remarks: Exposure period: 5 days; pre-mating exposure was 1.5 days for females.
Frequency of treatment: Cannot ascertain - in German.
Control group and treatment: Yes (treatment not specified)

Pre-Mating Exposure / Males: Pre-Mating Exposure / Females: 

### Test Results - Reproductive Toxicity Concentration (LOAEL/ LOAEC/ NOAEL/ NOAEC) : LOAEL/ LOAEC/ NOAEL/ NOAEC Population Value Description Value/Lower Concentration Upper Concentration Units

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:42:13 AM] Results: Remarks are in German.

Results Remarks:

Conclusion:


### Reliability/Data Quality - Reproductive Toxicity Reliability: 3 - Not Valid

Reliability Remarks:

Key Study Sponsor Indicator: 

### Reference - Reproductive Toxicity
Reference: IUCLID dataset