### P. 1



# OAR Box 1872 Prepped by Keeia Richards



# Document

Number: 

# 13 ) II-I-6 2
Docket Number: 

# A-90-1 9

Printed 11/26/20088:51:49AM

Sheet 13 of 204

# P. 2 

# nUs e
» 

# rme d :to r Stud y
r t appearin g las t

wee k i n ind Journal of Medicine. : takin g a325-miIligra m ever y othe r

da y ca n re enc e o f hear t attac k i n jve r 50
. letail s o f th e aspiri n stud y Januar y 1*88
. promptin g a y o n th e benefit s o

f takin g possibl e misinterpretatio n i s o f th e repor t

issue dlas t la s strongl y warne dU

S as - <o t t o promot e th e ne w find

an ddoctor s i develope dacommitte e o f > develo p recommendation s Researcher s wh o le dth e igains t takin g aspiri n o

n a :aus e 0 / potentia l sid e ef

easin g tb e ris k

fo r stomac h tai n kind s o

f stroke
. ) A concer n ove r

misinter

study' s findings
. Sterlin g market s Baye r

aspiri n re i e study' s publicatio n bu t i g tha t peopl e shoul dcon befor e beginnin g aregim e i n orde r t o preven t

hear t receive dFDA approva l t o > r preventin g secon dhear t attack s subsequen t

t o un - -ristol-Myer s Company , e aspiri n use di

n th e stud y 5 reporter s o

f th e study' s tore d22.07 1 health y mal e betwee n th e age s o

f 40 an d tudy bega n i

n 1982
. Half

o f n 325-milligra mo

f aspiri n le r day
. th e other s too k ikin g aspiri n ha d4

4 per attack s tha n th e placeb o leoc e o f strok e wa s slightl y ri n users , researcher s sai d ermn g stroke s an dcardio

- •maine dinconclusiv e



### lit y Product s tiona l Servic e u r Basi c Need s 

# AN D OIL S «FIN« O • u**rm

POPPVSEE D RIC E BRA N RAPESEE D SAEFLOWE R SESAM E SOYBEA N SUNFLOWE R TUN G ANIMA L FAT S FATTY ACID S SULFATE D OIL S

••OOUC T I—it ->___, ! «

_Omnumn Kr an y Sttmow

Coruonmor . vgrOmmaf

T*P Q Co>por»bo r 

# irfU
- •CACURKCO.MC
. t Mwn.N J 0710

6 -1300 F_i »'-4»-?__ - port s hav e als o dwindle dthi s year , contribut

in g t o phthali c softnes s a t born e Speaking abou t

eac h o f th e majo r

deman d area s fo r phthali c —plasticizers
. unsatu
rate dpolyeste r

resins , an dalky dresin s — source s i n th e industr y sa y tha t deman di s of

f 

# PRIC E TRENPUNE S WEE KENDIN G JUL Y 21

. 198 9 

### CHANGES/U P 

# AROMATI C ORGANIC

S Phthali c Maker

s Dro p Tabs , Loo k fo rComebac k

i n Fal l
Phthali c anhydrid e producer s ar e pro claimin g thei r

unhappines s wit h th e sof t stat e o f th e marke t

thi s year , bu t

the y ar e expressin g optimis mabou t th e mar ket' s likel y end-of-quarte r comeback , whic h the y sa y wil l b e aide db y lowe r prices
. Tw o majo r

marketers
. BAS FCorporatio n an dStepa n Company , announce dthree-cent

per-poun dpric e decrease s t o tak e effec t thi s mont h i n respons e t o afour-cen t cu t i n feed

stoc k ortho-xylen e tab s Othe r producers , whil e the y hav e no t

formall y declare dtha t tbe y ar e lowerin g prices , sa y tha t the y ar e eithe r meetin g competitiv e situation s o r as sessin g custome r

price s o n acase-by-cas e basi s A s on e phthali c produce r says , "W e lef t fo r vacatio n befor e th e Fourt h o f Jul y with 0

- xylen e a t 2 1 cent s pe r

pound , an dwhe n w e cam e bac k

w e foundi t a t 1 7 cents. " Tb e dro p wa s dramati c an dunexpected , an di t fol

lowe dalon g perio do

f tugher-than-norma i price s fo r th e primar y feedstoc k Fro mJanuar y 198 8 t o Januar y o f thi s year , o-xylen e price s rose fro m1 4 cent s pe r poun dt o 2

4 cents
. Durin g th e cours e o f thi s year , tab s hav e ease dslightly , dow n t o 2 3 cent s i n Ma

y an d2 1 cent s i n Jun e Phthali c producer s say tha t the y di dno t recove r th e ful l cos t

run-u p tha t

the y in

curred , an dtha t

fo r thi s reaso n thei r

ow n pric e cu t wa s 1 cen t

pe r poun dles s tha n thei r cos t drop , tb e proces s fo

r makin g phthali c anhydrid e fro mo-xylen e i s ver y nearl y a one-to-on e conversio n "We'r e passin g som e o

f th e cos t decreas e t o ou r customers , bu t

no t al l o f it
. becaus e w e di dno t ge t al l o f i t t o begi n with We'r e tryin g t o ge t margin s bac k

t o wher e tbe y wer e thi s tim e las t yea r "sayson e produce r FURTHE RDRO P T O COME " Ther e ha s bee n som e tal k o f afurthe r one cen t dro p i n o-xylen e price s fo r

August , bu t mos t peopl e agre e tha t

afte r suc h aprecipi

tou s dro p thi s month
. Augus t price s ar e likel y t o tak e awhil e t o settle
. Som e i n th e phthali c industr y sa y tha t the y woul dprobabl y no t

tak e thei r

own price s dow n anothe r

cen t eve n i f feedstoc k

cost s di d softe n further , agai n pointin g t o th e squeez e the y ha dbee n experiencin g fo r severa l month s Busines s ha s bee n of

f thi s year , especiall y when compare dt o las t

year' s recor dper formanc e Althoug h industr y source s dis

agre e wit h th e government' s IT C productio n figur e o f 1.1 4 billio n pound s fo r 1988
. th e estimate dI 0 5 billio n pound s tha t wer e pro duce di s arecor dfo

r th e industry , represent
ing almos t

9 4 percen t capacit y utilizatio n A n importan t

facto r i n las t year' s strengt h wa s th e expor t

market , whic h ha s al l bu t drie dup thi s year . Her e agai n thos e i n th e industr y sa y tha t

governmen t

figure s ar e overstated
. Tb e governmen t

reporte dtota l 198 8 ex port s o f 8 4 millio n pounds ; industr y source s plac e th e figur e close r

t o 7 5 millio n pounds , stil l arecor dfo r

offshor e shipments
. Chin awa s a n extremel y stron g buye r o f US-mad e phthali c anhydrid e fro mlat e 198 7 t o abou t Octobe r o f las t year . Wha

t on e sourc e call s a"once-in-a-lifetim e buyin g spree " b y Chin ao

f man y chemical s includin g phthali c drie du p shortl y afte r tha t tim e Chin aha s reportedl y bee n bac k i n th e mar ke t t o amuc h smalle r

degre e ove r

th e las t severa l months , but
. a s on e markete r says . "China' s politica l unres t

i s likel y t o se t

the m bac k acoupl e o

f year s (economically)
. It' s unfortunat e becaus e it' s atremendou s poten
tia l market " Anothe r sourc e say s tha t

Chin ai s keepin g it s door s ope n t o materia l fro mothe r coun tries , an dh e add s tha t

"Chin awil l definitel y com e bac k

(a s abuyer ) b y tb e beginnin g o f nex t yea r " Assertin g tha t

"Phthali c export s ar e dead. ' aproduce r

say s tha t

plasticize r

ex 

# A-90-1 9 H-l-6 2

CHANGES/DOW N Nor a 

### AROMATIC S INDE X Th e Aromati c Organics inde xreflect s th e price s o f 1 4 representativ e material s i n thi s secto ran d th e quantity of eac h produce d i n 198 7 Jul y 21.198 9 222.0 1 Jul y 14,198 9 222.0 1 Jun e 23.198 9 222.5 0 Jury 22.198 8 190.5 3 Crawne * MC M Star

t 0 * P»g » 4 2 compare dt o las t

year' s boomin g business , but tha t thes e en dmarket s d o no t see mfun

damentall y unhealth y Alkyd s ar e reporte dt o h e tb e marke t mos t affecte d b y wha tha s becom e a perennia l nuisanc e fo r

domesti c phthali c producer s imports
. Las t

yea r import s double dfro m1 5 millio n pound s i

n 1987 t o mor e tha n 3 0 mil

lio n pound s mostl y fro mMexic o an dSout h Americ a Tb e materia l tha t

come s mfro mabroa di s flake , whic h i

n th e U S represent s onl y abou t 1 0 percen t

o f tota l productio n Governmen t subsidie s o n feedstoc k

o-xylen e an dphthali c anhydrid e allo w foreig n manufacturer s t o sel l int o th e U

S fo r afew cent s les s tha n prevailin g marke t

price s Referrin g t o thes e practices , aU S mar kete r says . "I' mno t

sur e you hav e aleve l playin g fiel dwit

h thos e governmen t

subsi

dies. " Anothe r

put s i t mor e strongl y "Ther e ar e n o suit s filed , but

w e watc h th e import s closel y fo r

evidenc e o

f dumping. " H e add s that , wit h Fa r

Easter n market s showin g wea

k demand
. "Sout h America n countrie s wil l fin dth e U

S attractiv e an dshi p mor e materia l her e On th e brighte r

side , domesti c marketer s hav e thei r

hope s pinne do

n astron g resur genc e afte r

th e presen t

seasona l lul l "Tb e pric e cut s wil l hel p mak e fo r asignifican t comebac k

i n Septembe r

Yo u can' t hav e tha t muc h o f apric e decreas e withou t a n effect, ' say s asource . Anothe r says . "W e hop e t o se e astron g Fal l season , startin g aroun dth e en do f tb e thir dquarter
. Th e seasona l tren di s t o lif t u s bac k u p a t th e en do

f tb e quarte r

an dthe n tak e u s throug h Thanksgiving , with th e endo f th e yea r bein g muc h weake r

" H e add s tha t sign s o f astabilizin g econom y ar e aplu s fo r th e busines s Longe r term , peopl e u i th e industr y ar e fairl y optimistic
. Tb e industr y wen t throug h arationalizatio n proces s earlie r i n th e decade , an dn

o ne w capacit y i s expected
. Furthermore , o-xylen e price s ar e expecte d t o stabilize , no w tha t

the y hav e reache dhis

toricall y typica l level s i

n tb e mid-teen s A t leas t on e o r tw o othe r

producer s ar e considerin g joinin g Kopper s a s manufactur

er s whic h ru n o n adual-fee dsystem , incorpo

ratin g flexibilit y betwee n o-xylen e an dnaph

tbalen e Source s sa y tha t Kopper s an d foreig n naphthalene-base dproducer s hel da n advantag e durin g th e perio do i o-xylen e pric e run-ups . "I f afew producer s mov e mtha t direction
. w e woul dhav e alittl e mor e stabl e market' ' say s aproduce r

Aristec h Chemica l Corpor a uo o ha s state dtha t

i t aconsiderin g adual



# I f

yo u deman dqu a 0-ChSot < P- < 1 Organic Inlermeiliat, v from Rh The world

leader i n phi n , |

< Rhon i I n th e l S.:C N Bu i Le s Miroi r Te l 

# fP RHONE-POULENC 

# Fluorobenzen e

nowavailabl e i n commercia l quantitie s R y informatio n an d pric e quote , cal l Jame s Mavii n 1-800-325-8888 O write : Jame s W

. Havlin

. Aromati c Fluonn e Developmen t Mallinckrodt , Inc. , P O Bo x543 9 S t Louis

. M O 6314

7 PHON E 314-982-522 7 FA X 1-314-962-525 1


# K J4*jf24, 1 CHEMCAi
. UAKKFPHS ?*P

-P. 3

CH O
ropy l heiualdehydeiCUMA U

CH O 

# ICA1COMPAMT

. IH a

a l America . Inc . 2 2 U.S.A . OURNYKFK : NO W Yor k 798 - 401 2 s Chemica l Company . Inc . -Jaoarusche s Centra) , Wes t German y tOCD D to. I a-fc u Tokyo
. Japa n J Ftx: Toky

o 214093 8



# Product s i n tantities ! penno n ar e newl y availabl e fo r ;ke d u p wit h commercia l quantitie s m o f you rne w produc tSale s fo r ie w b y FMC .
OCH , 

# ">* r NHO H Hydnnami c aci d

CH 3 CHjOH Hydnnymeihylbipheny

l (HMBP ) 

# ! 

# 90 "

O H 2-Metl-llyloxyphenol (MOP ) 

# < 

# QQ <

NH20/ 2 HjS0 4 7-Aminobenzofura

n sulfat e 

# OO D CHEMICA L INC

. )FFICEBOX15 9 XDD , N J 0702 3 22-844 0 TELE X 84420 8 \ C FM C CORPORATIO N 

# AROMATIC S

feedstoc k system , an d source s sa y tha t Exxo n Chemica l Company i s als o weighin g th e relative merit s o

f implementin g such a system . (Se e Chemica l Profile , pag e 58) .



### RONBEGLEY
BTX —Th e spo tmarke tfo rbenzen e ha s bee n fairl y stabl e a t95c . pe r gallon , of f a penn y o rtw o fro m th e wee k endin g Jul y li . Contracts fo r th e mont

h stan d a tf

1.0 0 pe r gallon . FoUowin g downward gasolin e trends , spo t toluen e price s dippe d t o 80c . pe rgallo n las t week , dow

n 3 cent s o rs o fro m tb e previou s week . Xylen e contract s ar e at85c . pe rgallo n fo rJuly , wit h th e spo tmarke treporte d t o b e at90c . SULFANILI C ACI D - R- M Industrie s Inc . i s raisin g price s o

f it s extra-pur e grad e sulf anili c aci d and sodiu m sal teffectiv e Au gus t1 . Price s o

f extra-pur e (XP ) sulfanili c aci d wil l ris e 40c . pe r poun d t o $1.5 0 pe r poun d fo r40,80 0 poun

d minimnT

n shipments ; $1.6 0 fo r 24,00 0 poun d minimum ; an d $1.9 5 fo rshipment s o

f les s than 24,00 0 pounds . Sodiu m sal to f sulfanili c ad d wil l Increas e 5c . pe rpound , t o $1.0 4 fo r3 0 percen tsolutio n in 40,00 0 poun

d quantities , and t o $1.0 2 fo r dry powde rmateria l i n 40,00 0 poun d mini mum quantities . Al l price s ar e f.o.b . freigh t collect , For tMill , S.C . Paymen tterm s ar e net3 0 days . Tb e compan y attribute s th e increase s t o th e cos to

f upgradin g technica l grad e mate ria l t o hig h purity . Also , th e compan y stresse s tha tpricin g fo r technica l grad e ma teria l wil l remain unchange d at89c . pe r poun d i n 40,80 0 poun

d minimum^ ; 99c . pe r poun d fo r 24,00 0 pounds , and $1.3 5 fo r les s tha n 24,00 0 pounds . 

# Do w Make s Bi d Continue d fro m Pag e 9 cen tJ o 198 7 an d 14 percen tth e yea rbefore . Tb e compan y ha

d a retur n o o investmen t o f 4 4 percen tlas tyea rand 3 8 percen tth e yea rbefore , whil e th e industry averag e i s 2 9 to 3 0 percen tMr

. Sak s says . H e adds , "Tb e threa to

f generi c competi tio n represente d a

n increase d probability tha tif Marion wa s smar ti twoul d b e take n ou tButI didn' tthink i twoul d happe n s o soo n befor e 1992. " Wal l Stree tals o say s ther e i s littl e chanc e o f a spoile rtoppin g Dow' s bid , a s abou t2 3 percen to f Marion stoc k i s controlle d by th e Ewin g M . Kauffman family . Mr

. Kauffman i s Marion' s chairma n an d founde ran d co foundero f th e Kansa s Cit

y Royal s basebal l team ; h e say s th e famil y intend s t o suppor t th e acquisition . "Th e merge rwil l le tDo w expan d it s non cyclica l drug busines s and tak e advantag e o f Marion' s excellen tsale s force, " say s Harve y Stober , Dea n Witter s chemica l analys t H e estimate s tb e 3 9 percen ttakeove rwil l dilut e Do w share s by 30 cent s thi s yea rand th e 6 7 percen tstak e Do w wil l contro l i n th e earl y 1990 s wil l dilut e th e share s by a maxi mu m o f 5 0 cents . A Do w spokeswoma n say s th e compan y woul d hav e boughtMarion outrigh tbu ti t didn' twan tt o overburde n itsel f wit h deb tan d wishe d t o creat e a ne w compan y t o achiev e a highe rearnings-per-shar e valuation . A Merrel l Do w spokesma n say s th e com pan y decide d o n th e Marion marriag e be caus e "in al l Dow' s survey s o f possibl e com binations , Marion kep tcoinin g up d o top . W e bot h hav e a stron g emphasi s o n sale s per formanc e and qualit y manufacturing . W e als o believ e i n givin g employee s excellen t compensatio n and benefits. " While tb e tw o firms ' philosophie s ar e simi lar , th e difference s i n produc tline s als o mak e th e merge rhighl y complementary , th e Merrel l spokesma n says . While Marion i s referre d t o a s a "searc h an d development " company , which license s and develop s products fro m othe rconcern s (i tgo tbot h "Cardizem " an d "Carafate " fro m Japanes e companies ) Merrel l plan s t o spen d $19 0 millio n o n R& D thi s year . Th e spokesma n say s h e hope s ne w dosag e form s fo r "Cardizem " wil l prolon g th e drug' s popularit y eve n afte ri tlose s it s patent . Now , i tisth e leadin g cardiovascula rdrug i n th e US , h e says . Merrell' s larges tsellin g producti s "Sel dane, " antihistamin e wit h $J& 0 millio n in sales . I ti s expecte d t o becom e a $ 1 billio n produc tonc e i ti s markete d i n differen tcom binations , includin g a s "Seldan e D, " with a nasa l decongestan tan d i n ne w dosag e strengths . Merrel l Dow' s "Nicorette, " a chewin g gum tha thelp s smoker s qui tha d sale s o f about$10 0 millio n las tyear . Merrel l Dow' s pipelin e inclode s a n antibi oti c fo r hospitalize d patients , a drug fo rcon gestiv e hear tfailure , especiall y suite d fo r late rstage s o

f heartdiseases ; and a com poun d fo repilepsy . Al l thre e drag s hav e al read y been approve d i n Europe . Th e combine d compan y wil l hav e annual revenue s o

f abou t$2. 1 ballon . Merrel l Do w I s expecte d t o hav e sale s thi s yea ro f $1. 3 billio n notincludin g it s Lati n America n division , whic h wil l notb e parto f th e new company , and pretax earning s o

f $35 0 million . Marion earne d $15 0 millio n las tyea ro n $752 millio n i n sales . 

# HICKSO N ORGANI C INTERMEDIATE S NO W AVAILABL E INCLUDE :

3CNoro4nMthy«-NmcsyuftMf

w

3 Amin o 6 chtoRMcctanilid

e NHCOCH ,

3, 4 Dinitrocftloiobwizen

e 

# C l

2 Ruor o S nrtroanilin

e

NHCOCH , 4Chk>n>3 - nrtreacetenilid e

p-acetamido benzaldehyde

HKKSON 1 WELC H LT D ALS O OFFE R A FULL Y COMFHEHENSIVE . FULL Y CONFIDENTIA L CUSTO M SYNTHESI S FO « FUJTHE KDETAIL S CONTACT :

Dr . K.HOW.TC I Marketin g Manage r 

# HICKSO N & WELC H LTD

.

ITE R Jirt

y 24,198 9 

# fl > BAS F t o Tripl e Continue d tro

m Pag e 5 anc e an d processin g capabilitie s o f ou r man y engineerin g plastic s usin g production-siz e moldin g an

d extrusio n equipment . Thi s wil l allo w BAS F t o wor

k closel y with customer s i n developin g optimize d partdesign s an d processin g conditions. " BAS F i s preparin g t o introduc e a polystyrene/polyethylen e polyme rblen d lo r packaging , accordin g to Albrech tEckell , managin g director , engineerin g plastics , BAS F Group . Th e 50:5 0 blen d contain s a "ver y specia l additive " thatallow s th e tw o polymer s t o combin e i n a stabl e blend . Dr . Eckel l says . Impermeabl e t o moisture , th e ne w poly me rblend wil l b e targete d a tpackagin g ap plications , particularl y to r food . Dr . Eckell , base d i n Ludwigshafen . Wes tGermany , points ou tthatth e new polyme rblen d wil l b e markete d solel y in Wester n Europe . Itwil l b e officiall y introduce d a

tth e "K O Dr . Eckel l state s tha tBAS F wil l inves t $1. 5 billio n ove rth e nexteigh tyear s fo rengi neerin g plastics , wit

h a "substantial part " o

f th e expenditure s earmarke d (o rth e US . Plastic s contribute d $4. 6 billio n t o BAS F Group' s worldwid e sale s las tyear , or1 8 per cen to f th e total , a dolla rfigur e tha i woul d plac e th e plastic s busines s o n th e Fortun e 10

0 lis tin th e US , Dr . Eckel l says . Projectin g mid-ter m futur e deman d growth , b e see s PVC consumptio n growin g a t 2 percen tpe ryear , and LDP E an d LLDPE growin g a t2. 5 percen tperyear . HDP E an d polypropylen e shoul d experienc e 4. 5 percen t an d 6 percen tconsumptio n growth , respec tively . Engineerin g resin s wil l gro w a n averag e o

f 5. 5 percen tper year . Dr . Eckel l says , wit h high temperatur e resistan tplastic s an d liq ui d crysta l polymer s demonstratin g th e sharpes tgrowth , albei tfro m a smal l bas e Manfre d Buller . presidento

f BAS F Corporation' s polymer s divisio n and executiv e vice-presiden twit

h th e corporation , fore cast s goo d growt

h fo rth e individua

l busines s group s withi n hi s division . I n Nort h America . th e polymer s divisio n account s fo r 1 5 per cen to f tota l BAS F Corporatio n sales , simila r t o th e worldwid e figur e state d above . Th e polyurethane s busines s represent s th e larges tsingl e portio n o f th e polymer s divi sion . Dr . Bulle rsays . H

e points to 5 percen t annua l growt h ove rth e las tte n years , an d he call s for3 percen tannua

l growt h for th e next thre e years . Referrin g to th e company' s plasti c foam s business . Dr

. Bulle r says , "Her

e i n th e U S w e hav e maintaine d ou

rleadershi p positio n an

d ou rshar e i n th e EP S (expandabl e polystyrene ) market , which ha s shown an nua l growt h rate s o t5 to 7 percentove rth e las tte n years. " H e forecast s 5 percen tgrowt h per yea r ove rth e nex tthre e years , and say s thatth e compan y ha s successfull y broadene d i t produc tlin e into expande d polyole f ins . Th e marke tfo r th e company' s structural material s product

s in expecte d to continu e it s double-digi tgrowt

h rate . Th e plasti c ma terial s group , le d b

y Dr . Praetorius . i s activ e i n a marke ttha tha s show n 6 percen tgrowt h peryea rove rth e las tte n years , a rate ex pecte d t o continu e fo r th e nex tdecade . Dr . Bulle rsay s tha

tUS Polymer s expenditure s ove rth e nex tfiv e year s wil l b e i n exces s o f $10 0 millio n pe ryear .



# Benzen e Sulfoni c Pheno l Sulfoni c Aci

c C Slos s Industrie s als o produce s iro n An d as k 

# iiNOuerrai E