Fenpyroximate Dietary Exposure and Risk Assessment DP# 405718

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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

OFFICE OF

CHEMICAL SAFETY AND

POLLUTION PREVENTION

Date: 08-MAY-2013

Subject: Fenpyroximate. Petition for the Establishment of Permanent Tolerances for 

Residues in/on Stone Fruits (Group 12-12), Tuberous and Corm Vegetables 

(Subgroup 1C), and Small Vine Climbing Fruits Except Kiwifruit (Subgroup 13-07F). 

Acute and Chronic Dietary Exposure and Risk Assessments.

PC Code: 129131 DP Barcode: D405718

Decision No.: 468635 Registration Nos: 71711-19, 71711-4

Petition No.: 2E8072 Regulatory Action: Sec. 3 Registration

Risk Assessment Type: Dietary Case No.: 7432

TXR No.: NA CAS No.: 134098-61-6 (E-isomer)

MRID No.: None 40 CFR: §180.566

From: George F. Kramer, Ph.D., Senior Chemist

Risk Assessment Branch 1 (RAB1)

Health Effects Division (HED; 7509P)

Through: Julie L. Van Alstine, MPH, Environmental Health Scientist

Thurston Morton, Chemist

Dietary Exposure Science Advisory Council (DESAC)/HED (7509P)

and

Dana M. Vogel, Acting Branch Chief, RAB1

Associate Division Director, HED (7509P)

To: Jennifer R. Tyler, Risk Assessor

RAB1/HED (7509P)

and

Barbara Madden/Sidney Jackson, RM 05

Registration Division (RD; 7505P)

Executive Summary

Acute and chronic aggregate dietary (food + drinking water) exposure and risk assessments were 

conducted for fenpyroximate using the Dietary Exposure Evaluation Model - Food Consumption 

Intake Database (DEEM-FCID, ver. 3.16) which incorporates consumption data from United 

States Department of Agriculture (USDA) National Health and Nutrition Examination Survey, 

What We Eat in America, (NHANES/WWEIA; 2003-2008). The analyses were performed to 

support Section 3 use requests on stone fruits (group 12-12), small vine climbing fruits except 

kiwifruit (subgroup 13-07F), and tuberous and corm vegetables (subgroup 1C).
Fenpyroximate Dietary Exposure and Risk Assessment DP# 405718

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Acute Dietary (Food + Drinking Water) Exposure Results and Characterization

Separate acute dietary risk analyses were conducted for females 13-49 years old and for the 

general U.S. population, as separate endpoints of concern attributable to a single dose were 

identified. Both acute analyses assumed 100% crop treated (CT), tolerance-level residues for all 

commodities. DEEM (ver. 7.81) default processing factors were assumed for all commodities 

excluding apple, pear, and grape juice (0.11x); grape, raisin (2.7x); orange, grapefruit, tangerine, 

lemon, and lime juice (0.06x); tomato paste (1.0x) and puree (1.0x); dried plum (1.0x); and 

peppermint and spearmint oil (0.08x). The acute analyses incorporated the estimated drinking 

water concentrations (EDWCs) provided by Environmental Fate and Effects Division (EFED). 

An EDWC of 0.043 ppm was used in the acute analyses, as this was the highest (i.e., most 

conservative) estimate. 

The resulting acute food plus drinking water risk estimates are not of concern to HED (<100% 

acute population-adjusted dose (aPAD)) at the 95th percentile of the exposure. The resulting 

acute risk estimate is 13% of the aPAD at the 95th percentile of the exposure distribution for 

females 13 to 49 years old. The highest acute exposure estimate for the U.S. population or 

population subgroup is children 1-2 years old, which resulted in a risk estimate of 6.2% aPAD.

Chronic Dietary (Food + Drinking Water) Exposure Results and Characterization

The chronic analysis assumed DEEM (ver. 7.81) default processing factors, 100% CT, tolerancelevel residues for all commodities, and DEEM (ver. 7.81) default processing factors for most 

commodities (see above). The chronic analysis also incorporated EDWCs provided by EFED 

(an EDWC of 0.0086 ppm was used in the chronic analysis). The resulting chronic risk 

estimates are not of concern to HED. The most highly exposed population was children 1-2 

years old utilizing 15% of the chronic PAD (cPAD).

A chronic cancer dietary assessment was not conducted since it was determined that 

fenpyroximate is not a possible human carcinogen. 

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). 

This dose is referred to as the PAD. The PAD is equivalent to point of departure (POD, 

NOAEL, LOAEL, e.g.) divided by the required uncertainty and/or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. References which discuss the acute and chronic risk assessments in 

more detail are available on the EPA/pesticides web site: “Available Information on Assessing 

Exposure from Pesticides, A User’s Guide,” 21-JUN-2000, web link: 

http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf; or see SOP 99.6 (20-AUG1999).

The most recent dietary risk assessment for fenpyroximate was conducted by S. Levy (23-MAY2012; DP# 391844).
Fenpyroximate Dietary Exposure and Risk Assessment DP# 405718

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II. Residue Information

Fenpyroximate is a contact insecticide/miticide used for the control of leafhoppers, mealybugs, 

and mites. Fenpyroximate is a mitochondrial electron-transport inhibitor (METI) which acts by

targeting proton-translocating NADH:Q oxidoreductase and blocking ubiquinone reduction.

Residues of Concern: Acceptable plant metabolism studies with fenpyroximate on apples, citrus, 

cotton, and grapes were previously submitted. HED has determined (Memo, J. Stokes, 12-AUG2003; D292639) that the residues of concern for plants for the purposes of tolerance enforcement 

and risk assessment are fenpyroximate 4-[[[(E)-[(1,3-dimethyl-5-phenoxy-1H-pyrazol-4-yl)

methylene]amino]oxy] methyl]benzoate plus its Z-isomer (also called metabolite M-1 or 4-

[[[(Z)-[(1,3-dimethyl-5-phenoxy-1H-pyrazol-4-yl) methylene]amino]oxy]methyl]benzoate). 

The nature of residue in lactating goats is understood. The HED Metabolism Assessment 

Review Committee (MARC) concluded that for milk and the fat, meat, and meat byproducts 

(excluding liver and kidney) of cattle, goat, horse, and sheep, the parent compound, and its 

metabolites (E)-4-[(1,3-dimethyl-5-phenoxypyrazol-4-yl)-methylene aminooxymethyl]benzoic 

acid and (E)-1,1-dimethylethyl-2-hydroxyethyl 4-[[[[(1,3-dimethyl-5-phenoxy-1H-pyrazol-4-yl) 

methylene] amino]oxy]methyl]benzoate, calculated as the parent compound, are the residues of 

concern (Memo, J. Stokes, 12-AUG-2003; D292639). Additionally, the residues of concern for 

cattle, goat, horse, and sheep liver and kidney are fenpyroximate and its metabolite (E)-4-[(1,3-

dimethyl-5-phenoxypyrazol-4-yl)-methylene aminooxymethyl]benzoic acid, calculated as the 

parent compound.

For drinking water, the residues of concern for risk assessment include the parent, M-1 and M-3.

Established/Recommended Tolerances: Fenpyroximate tolerances are established in 40 CFR 

§180.566. Tolerances for residues in/on plant commodities are expressed in terms of the 

combined residues of fenpyroximate and its Z-isomer. Permanent tolerances for residues in/on 

plant commodities, under §180.566(a)(1), range from 0.10 ppm to 20 ppm. Tolerances for 

residues in/on milk and the fat, meat, and meat byproducts (excluding liver and kidney) of cattle, 

goat, horse, and sheep are listed in 40 CFR §180.566(a)(2) and are expressed in terms of the 

combined residues of fenpyroximate and its metabolites (E)-4-[(1,3-dimethyl-5-phenoxypyrazol4-yl)-methylene aminooxymethyl]benzoic acid and (E)-1,1-dimethylethyl-2-hydroxyethyl 4-

[[[[(1,3-dimethyl-5-phenoxy-1H-pyrazol-4-yl)methylene]amino]oxy]methyl]benzoate, calculated 

as the parent compound. Tolerances for residues in cattle, goat, horse, and sheep liver and 

kidney are listed under 40 CFR §180.566(a)(3) at 0.25 ppm and are expressed in terms 

fenpyroximate and its metabolite (E)-4-[(1,3-dimethyl-5-phenoxypyrazol-4-yl)-methylene 

aminooxymethyl]benzoic acid, calculated as the parent compound. A time-limited tolerance for 

residues in/on honey at 0.10 ppm with a 12/31/13 expiration date is listed in 40 CFR §180.566(b) 

under a Section 18 Emergency Exemption. 

The Interregional Project No. 4 (IR-4) has proposed a Section 3 Registration for application of 

fenpyroximate to stone fruits (group 12-12), small vine climbing fruits except kiwifruit 

(subgroup 13-07F), and tuberous and corm vegetables (subgroup 1C). IR-4, requests the 

establishment of tolerances for the combined residues of the insecticide fenpyroximate in/on the 

following raw agricultural commodities (RACs). 
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Commodity HED-Recommended Tolerance (ppm)

Fruit, stone, group 12-12 2.0

Vegetable, tuberous and corm, subgroup lC 0.10

Fruit, small, vine climbing, except fuzzy 

kiwifruit, subgroup 13-07F

1.0

No new residue data were submitted to support tolerance on small vine climbing fruits except 

kiwifruit (subgroup 13-07F). IR-4 has requested that the established tolerance for residues in/on 

grape be expanded to its respective crop group.

Residues used in the Acute and Chronic Analysis: These analyses employed established and HEDrecommended tolerance-level residues for all commodities and DEEM (ver. 7.81) default 

processing factors for all commodities excluding apple, pear, and grape juice (0.11x); grape, raisin 

(2.7x); orange, grapefruit, tangerine, lemon, and lime juice (0.06x); tomato paste (1.0x) and puree 

(1.0x); dried plum (1.0x); and peppermint and spearmint oil (0.08x).

III. EDWCs

Drinking water residues were incorporated directly into the acute and chronic dietary analyses 

(“water, direct, all sources” and “water, indirect, all sources”) and were provided by EFED 

(Memo, G. Orrick, 20-SEP-2012; D404840). The EDWCs were screening-level estimates 

generated with the Food Quality Protection Act (FQPA) Index Reservoir Screening Tool 

(FIRST) and a Provisional Cranberry Model for fenpyroximate and its metabolites (M-1 and M3) in surface water and with Screening Concentration in Ground Water (SCI-GROW) for ground 

water. Although the current and proposed end-use labels that result in the highest exposure are 

for ornamentals (an application rate to ornamentals of 0.343 lbs ai/A with a maximum 

application of 0.686 lbs ai/A), the use scenario with the highest acute and chronic EDWCs are 

for the cranberry scenario (see Table 1).

Table 1. Maximum Screening EDWCs of Fenpyroximate for Current and Proposed Uses.1

Drinking Water Source (model)

Use (Maximum Annual 

Rate)

Upper-Bound Estimated Drinking 

Water Concentrations (ppb)

Acute (peak 

exposure)

Chronic (annual 

mean exposure)

Surface Water (FIRST) Ornamentals (0.69 lb ai/A) 29 1.9

Surface Water (Cranberry model) Cranberries (0.20 lb ai/A) 43 8.6

Groundwater (SCI-GROW) Ornamentals (0.69 lb ai/A) <0.27

1 Maximum values in bold.

Surface water EDWCs of 0.043 ppm and 0.0086 ppm were used in the acute and chronic 

analyses, respectively, as these values were the highest and provided a more conservative 

approach.

IV. DEEM-FCID Program and Consumption Information

Fenpyroximate acute and chronic dietary exposure assessments were conducted using DEEMFCID (ver. 3.16) which incorporates consumption data from USDA’s NHANES/WWEIA. This 

dietary survey was conducted from 2003 to 2008. The data are based on the reported 

consumption of more than 20,000 individuals over two non-consecutive survey days. Foods “as 
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consumed” (e.g., apple pie) are linked to EPA-defined food commodities (e.g., apples, peeled 

fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly 

available recipe translation files developed jointly by USDA/ARS and EPA. For chronic 

exposure assessment, consumption data are averaged for the entire U.S. population and within 

population subgroups. Based on analysis of the 2003-2008 WWEIA consumption data, which 

took into account dietary patterns and survey respondents, HED concluded that it is most 

appropriate to report risk for the following population subgroups: the general U.S. population, all 

infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, 

females 13-49, and adults 50-99 years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form to produce a residue intake estimate. 

The resulting residue intake estimate for each food/food form is summed with the residue intake 

estimates for all other food/food forms on the commodity residue list to arrive at the total 

average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent 

of the cPAD. This procedure is performed for each population subgroup.

For acute exposure assessments, individual one-day food consumption data are used on an 

individual-by-individual basis. The reported consumption amounts of each food item can be 

multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a 

deterministic exposure assessment, or “matched” in multiple random pairings with residue values 

and then summed in a probabilistic assessment. The resulting distribution of exposures is expressed 

as a percentage of the aPAD on both a user (i.e., only those who reported eating relevant 

commodities/food forms) and a per-capita (i.e., those who reported eating the relevant commodities 

as well as those who did not) basis. In accordance with HED policy, per capita exposure and risk are 

reported for all tiers of analysis. However, for Tiers 1 and 2, any significant differences in user vs. 

per capita exposure and risk are specifically identified and noted in the risk assessment.

V. Toxicological Information

The toxicological endpoints as presented in the previous risk assessment are summarized below 

in Table 2.
Fenpyroximate Dietary Exposure and Risk Assessment DP# 405718

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Table 2. Summary of Toxicological Dose and Endpoints for Fenpyroximate for Use in Dietary Risk Assessment1.

Exposure

Scenario

Point of 

Departure

Uncertainty/FQPA Safety 

Factors Study and Toxicological Effects

Acute Dietary

(Females 13-49 

years old)

NOAEL = 5.0

mg/kg bw

UF = 100X

(for inter- and intra-species 

extrapolation)

FQPA SF = 1X

aRfD = aPAD = 0.05 mg/kg bw

Prenatal Developmental Toxicity Study - Rat

LOAEL = 25 mg/kg/day based on increase in 

the fetal incidence of additional thoracic ribs.

Acute Dietary

(General 

population)

NOAEL = 37.5 

mg/kg bw

UF = 100X

(for inter- and intra-species 

extrapolation)

FQPA SF = 1X

aRfD = aPAD = 0.375 mg/kg 

bw

Acute Neurotoxicity Study – Rat

LOAEL = 150 mg/kg bw based on decreased 

motor activity (total activity counts and total 

time spent in movement) in both sexes, and a 

reduction in auditory startle response in females 

at 24 hours post dose, and mild dehydration in 

males.

Chronic Dietary

(All populations)

NOAEL = 5.0

mg/kg/day

UF = 100X

(for inter- and intra-species 

extrapolation)

FQPA SF = 1X

cRfD = cPAD

= 0.05 mg/kg/day

Chronic toxicity - Dog

LOAEL = 15 mg/kg/day based on an increased 

incidence of bradycardia, diarrhea, and 

decreases in cholesterol, body-weight gain, and 

food consumption (M); vomiting, diarrhea, 

excess salivation and decrease cholesterol in 

females.

Cancer 

(Oral, dermal, 

inhalation)

Classification: “Not likely to be carcinogen,” cancer risk assessment is not required.

1

 NOAEL = no-observed adverse-effect level, LOAEL = lowest-observed adverse-effect level, RfD = reference 

dose, PAD = population-adjusted dose (a = acute, c = chronic), MOE = margin of exposure, UF = uncertainty factor, 

SF = safety factor.

VI. Results/Discussion

Acute and chronic analyses were performed using DEEM-FCID (ver. 3.16). DEEM-FCID (ver. 

3.16) estimates the dietary exposure of the U.S. population and various population subgroups. 

The results reported are for the general U.S. population, all infants (<1 year old), children 1-2 

years old, children 3-5 years old, children 6-12 years old, youth 13-19 years old, females 13-49 

years old, adults 20-49 years old, and adults 50-99 years old. 

The resulting acute food plus drinking water risk estimates are not of concern to HED (<100% 

aPAD) at the 95th percentile of the exposure. The resulting acute risk estimate is 13% of the 

aPAD at the 95th percentile of the exposure distribution for females 13 to 49 years old. The 

highest acute exposure estimate for the U.S. population or population subgroup is children 1-2 

years old, which resulted in a risk estimate of 6.2% aPAD.

The resulting chronic exposure estimates are not of concern to HED. The most highly exposed 

population was children 1-2 years old utilizing 15% of the cPAD (see Table 3 for a summary of 

the results). A chronic cancer dietary assessment was not conducted since it was determined that 

fenpyroximate is not a possible human carcinogen. 
Fenpyroximate Dietary Exposure and Risk Assessment DP# 405718

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Table 3. Summary of Dietary (Food + Drinking Water) Exposure and Risk for Fenpyroximate.

Population Subgroup1

Acute Dietary2

(95 Percentile) Chronic Dietary3 Cancer

Dietary

Exposure 

(mg/kg/day) % aPAD

Dietary 

Exposure

(mg/kg/day) % cPAD

Dietary 

Exposure

(mg/kg/day) Risk

General U.S. Population 0.008312 2.2 0.002208 4.4

NA NA

All Infants (<1 year old) 0.022585 6.0 0.004700 9.4

Children 1-2 years old 0.023191 6.2 0.007336 15

Children 3-5 years old 0.016596 4.4 0.005098 10

Children 6-12 years old 0.009835 2.6 0.002723 5.4

Youth 13-19 years old 0.005336 1.4 0.001394 2.8

Adults 20-49 years old 0.006565 1.8 0.001712 3.4

Adults 50-99 years old 0.006917 1.8 0.002013 4.0

Females 13-49 years old 0.006685 13 0.001693 3.4

1

 The values for the highest exposed population for each type of risk assessment is bolded.

2

 Separate acute toxicity endpoints were determined for females 13-49 years old and the general U.S. population 

and all population subgroups (see Table 2).

3

 Chronic dietary endpoint of 0.05 mg/kg/day applies to the general U.S. population and all population subgroups. 

VII. Characterization of Inputs/Outputs

The acute and chronic analyses assumed tolerance-level residues, 100% CT, DEEM (ver. 7.81) 

default processing factors for all commodities excluding apple, pear, and grape juice (0.11x); 

grape, raisin (2.7x); orange, grapefruit, tangerine, lemon, and lime juice (0.06x); tomato paste 

(1.0x) and puree (1.0x); dried plum (1.0x); and peppermint and spearmint oil (0.08x). These 

analyses are considered very conservative and could be refined through the use of anticipatedresidue estimates (ARs) for all commodities, percent market share data for the proposed 

commodities, %CT data for registered commodities, and/or additional empirical processing 

factors. However, at this time refinement is not necessary.

VIII. Conclusions

The acute and chronic dietary exposure and risk assessments were conducted using DEEMFCID, ver. 3.16. DEEM-FCID incorporates food consumption data from the USDA's

NHANES/WWEIA. 

Separate acute dietary risk analyses were conducted for females 13-49 years old and for the 

general U.S. population, as separate endpoints of concern attributable to a single dose were 

identified. Both acute analyses assumed tolerance-level residues, 100% CT, DEEM (ver. 7.81) 

default processing factors for all commodities excluding apple, pear, and grape juice (0.11x);

grape, raisin (2.7x); orange, grapefruit, tangerine, lemon, and lime juice (0.06x); tomato paste 

(1.0x) and puree (1.0x); dried plum (1.0x); and peppermint and spearmint oil (0.08x). The acute 

analyses also incorporated the drinking water estimates provided by EFED. The EDWCs were 

unrefined estimates for surface water calculated using the Provisional Cranberry Model for 

fenpyroximate and its metabolites (an EDWC of 0.043 ppm was used in the acute analyses). The 

resulting acute food plus drinking water risk estimates are not of concern to HED (<100% 

aPAD) at the 95th percentile of the exposure distribution for females 13 to 49 years old or the 

general U.S. population. The resulting acute risk estimate is 13% of the aPAD at the 95th

percentile of the exposure distribution for females 13 to 49 years old. The highest acute 
Fenpyroximate Dietary Exposure and Risk Assessment DP# 405718

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exposure estimate for the U.S. population or population subgroup is children 1-2 years old, 

which resulted in a risk estimate of 6.2% aPAD.

The chronic analysis assumed tolerance-level residues, 100% CT, DEEM (ver. 7.81) default 

processing factors for most commodities (see above). The chronic analysis also incorporated the 

drinking water estimates provided by EFED. The EDWCs were unrefined estimates for surface 

water calculated using the Provisional Cranberry Model for fenpyroximate and its metabolites 

(an EDWC of 0.0086 ppm was used in the chronic analysis). The resulting chronic risk

estimates are not of concern to HED. The most highly exposed population was children 1-2 

years old utilizing 15% of the cPAD.

Attachments

Attachment 1: DEEM-FCID Acute Food + Drinking Water Residue Input File.

Attachment 2: DEEM-FCID Acute Exposure Estimates for Females 13-49 Years Old.

Attachment 3: DEEM-FCID Acute Exposure Estimates for the General U.S. Population Subgroup.

Attachment 4: DEEM-FCID Chronic Food + Drinking Water Residue Input File.

Attachment 5: DEEM-FCID Chronic Exposure Estimates.

cc: G. Kramer (RAB1)

RDI: DE SAC Reviewers (28-JAN-2013)

G.F. Kramer:S10957:PY-S:(703)305-5079:7509P:RAB1
Fenpyroximate Dietary Exposure and Risk Assessment DP# 405718

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Attachment 1: DEEM-FCID Acute Food + Drinking Water Residue Input File.

Filename: C:\Documents and Settings\gkramer\My Documents\Gk\#$Fenpyroximate\129131a.R08

Chemical: Fenpyroximate

RfD(Chronic): .05 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .375 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 01-24-2013/14:17:01 Program ver. 3.16, 03-08-d

Comment: New uses; added additional acute endpt. for general population

-----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

0103015000 1CD Arrowroot, flour 0.100000 1.000 1.000 

0103015001 1CD Arrowroot, flour-babyfood 0.100000 1.000 1.000 

0103017000 1CD Artichoke, Jerusalem 0.100000 1.000 1.000 

0103082000 1CD Cassava 0.100000 1.000 1.000 

0103082001 1CD Cassava-babyfood 0.100000 1.000 1.000 

0103139000 1CD Dasheen, corm 0.100000 1.000 1.000 

0103166000 1CD Ginger 0.100000 1.000 1.000 

0103166001 1CD Ginger-babyfood 0.100000 1.000 1.000 

0103167000 1CD Ginger, dried 0.100000 1.000 1.000 

0103296000 1C Potato, chips 0.100000 1.000 1.000 

0103297000 1C Potato, dry (granules/ flakes) 0.100000 6.500 1.000 

0103297001 1C Potato, dry (granules/ flakes)-b 0.100000 6.500 1.000 

0103298000 1C Potato, flour 0.100000 6.500 1.000 

0103298001 1C Potato, flour-babyfood 0.100000 6.500 1.000 

0103299000 1C Potato, tuber, w/peel 0.100000 1.000 1.000 

0103299001 1C Potato, tuber, w/peel-babyfood 0.100000 1.000 1.000 

0103300000 1C Potato, tuber, w/o peel 0.100000 1.000 1.000 

0103300001 1C Potato, tuber, w/o peel-babyfood 0.100000 1.000 1.000 

0103366000 1CD Sweet potato 0.100000 1.000 1.000 

0103366001 1CD Sweet potato-babyfood 0.100000 1.000 1.000 

0103371000 1CD Tanier, corm 0.100000 1.000 1.000 

0103387000 1CD Turmeric 0.100000 1.000 1.000 

0103406000 1CD Yam, true 0.100000 1.000 1.000 

0103407000 1CD Yam bean 0.100000 1.000 1.000 

0601043000 6A Bean, snap, succulent 0.400000 1.000 1.000 

0601043001 6A Bean, snap, succulent-babyfood 0.400000 1.000 1.000 

0801374000 8A Tomatillo 0.200000 1.000 1.000 

0801375000 8A Tomato 0.200000 1.000 1.000 

0801375001 8A Tomato-babyfood 0.200000 1.000 1.000 

0801376000 8A Tomato, paste 0.200000 1.000 1.000 

0801376001 8A Tomato, paste-babyfood 0.200000 1.000 1.000 

0801377000 8A Tomato, puree 0.200000 1.000 1.000 

0801377001 8A Tomato, puree-babyfood 0.200000 1.000 1.000 

0801378000 8A Tomato, dried 0.200000 14.300 1.000 

0801378001 8A Tomato, dried-babyfood 0.200000 14.300 1.000 

0801379000 8A Tomato, juice 0.200000 1.500 1.000 

0801380000 8A Tomato, Tree 0.200000 1.000 1.000 

0802148000 8BC Eggplant 0.200000 1.000 1.000 

0802234000 8BC Okra 0.200000 1.000 1.000 

0802270000 8B Pepper, bell 0.200000 1.000 1.000 

0802270001 8B Pepper, bell-babyfood 0.200000 1.000 1.000 

0802271000 8B Pepper, bell, dried 0.200000 1.000 1.000 

0802271001 8B Pepper, bell, dried-babyfood 0.200000 1.000 1.000 

0802272000 8BC Pepper, nonbell 0.200000 1.000 1.000 

0802272001 8BC Pepper, nonbell-babyfood 0.200000 1.000 1.000 

0802273000 8BC Pepper, nonbell, dried 0.200000 1.000 1.000 

0901075000 9A Cantaloupe 0.100000 1.000 1.000 

0901187000 9A Honeydew melon 0.100000 1.000 1.000 

0901399000 9A Watermelon 0.100000 1.000 1.000 

0901400000 9A Watermelon, juice 0.100000 1.000 1.000 

0902135000 9B Cucumber 0.400000 1.000 1.000 

1001106000 10A Citron 0.500000 1.000 1.000 

1001107000 10A Citrus hybrids 0.500000 1.000 1.000 

1001108000 10A Citrus, oil 10.000000 1.000 1.000 

1001240000 10A Orange 0.500000 1.000 1.000 

1001241000 10A Orange, juice 0.500000 0.060 1.000 

1001241001 10A Orange, juice-babyfood 0.500000 0.060 1.000 

1001242000 10A Orange, peel 0.500000 1.000 1.000 
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1001369000 10A Tangerine 0.500000 1.000 1.000 

1001370000 10A Tangerine, juice 0.500000 0.060 1.000 

1002197000 10B Kumquat 0.500000 1.000 1.000 

1002199000 10B Lemon 0.500000 1.000 1.000 

1002200000 10B Lemon, juice 0.500000 0.060 1.000 

1002200001 10B Lemon, juice-babyfood 0.500000 0.060 1.000 

1002201000 10B Lemon, peel 0.500000 1.000 1.000 

1002206000 10B Lime 0.500000 1.000 1.000 

1002207000 10B Lime, juice 0.500000 0.060 1.000 

1002207001 10B Lime, juice-babyfood 0.500000 0.060 1.000 

1003180000 10C Grapefruit 0.500000 1.000 1.000 

1003181000 10C Grapefruit, juice 0.500000 0.060 1.000 

1003307000 10C Pummelo 0.500000 1.000 1.000 

1100007000 11 Apple, fruit with peel 0.300000 1.000 1.000 

1100008000 11 Apple, peeled fruit 0.300000 1.000 1.000 

1100008001 11 Apple, peeled fruit-babyfood 0.300000 1.000 1.000 

1100009000 11 Apple, dried 0.300000 8.000 1.000 

1100009001 11 Apple, dried-babyfood 0.300000 8.000 1.000 

1100010000 11 Apple, juice 0.300000 0.110 1.000 

1100010001 11 Apple, juice-babyfood 0.300000 0.110 1.000 

1100011000 11 Apple, sauce 0.300000 1.000 1.000 

1100011001 11 Apple, sauce-babyfood 0.300000 1.000 1.000 

1100129000 11 Crabapple 0.300000 1.000 1.000 

1100173500 11 Goji berry 0.200000 1.000 1.000 

1100210000 11 Loquat 0.300000 1.000 1.000 

1100266000 11 Pear 0.300000 1.000 1.000 

1100266001 11 Pear-babyfood 0.300000 1.000 1.000 

1100267000 11 Pear, dried 0.300000 6.250 1.000 

1100268000 11 Pear, juice 0.300000 0.110 1.000 

1100268001 11 Pear, juice-babyfood 0.300000 0.110 1.000 

1100310000 11 Quince 0.300000 1.000 1.000 

1201090000 12A Cherry 2.000000 1.000 1.000 

1201090001 12A Cherry-babyfood 2.000000 1.000 1.000 

1201091000 12A Cherry, juice 2.000000 1.500 1.000 

1201091001 12A Cherry, juice-babyfood 2.000000 1.500 1.000 

1202012000 12B Apricot 2.000000 1.000 1.000 

1202012001 12B Apricot-babyfood 2.000000 1.000 1.000 

1202013000 12B Apricot, dried 2.000000 6.000 1.000 

1202014000 12B Apricot, juice 2.000000 1.000 1.000 

1202014001 12B Apricot, juice-babyfood 2.000000 1.000 1.000 

1202230000 12B Nectarine 2.000000 1.000 1.000 

1202260000 12B Peach 2.000000 1.000 1.000 

1202260001 12B Peach-babyfood 2.000000 1.000 1.000 

1202261000 12B Peach, dried 2.000000 7.000 1.000 

1202261001 12B Peach, dried-babyfood 2.000000 7.000 1.000 

1202262000 12B Peach, juice 2.000000 1.000 1.000 

1202262001 12B Peach, juice-babyfood 2.000000 1.000 1.000 

1203285000 12C Plum 2.000000 1.000 1.000 

1203285001 12C Plum-babyfood 2.000000 1.000 1.000 

1203286000 12C Plum, prune, fresh 2.000000 1.000 1.000 

1203286001 12C Plum, prune, fresh-babyfood 2.000000 1.000 1.000 

1203287000 12C Plum, prune, dried 2.000000 1.000 1.000 

1203287001 12C Plum, prune, dried-babyfood 2.000000 1.000 1.000 

1203288000 12C Plum, prune, juice 2.000000 1.400 1.000 

1203288001 12C Plum, prune, juice-babyfood 2.000000 1.400 1.000 

1302057000 13B Blueberry 1.000000 1.000 1.000 

1302057001 13B Blueberry-babyfood 1.000000 1.000 1.000 

1302174000 13B Gooseberry 1.000000 1.000 1.000 

1304175000 13D Grape 1.000000 1.000 1.000 

1304176000 13D Grape, juice 1.000000 0.110 1.000 

1304176001 13D Grape, juice-babyfood 1.000000 0.110 1.000 

1304179000 13D Grape, wine and sherry 1.000000 1.000 1.000 

1307130000 13G Cranberry 1.000000 1.000 1.000 

1307130001 13G Cranberry-babyfood 1.000000 1.000 1.000 

1307131000 13G Cranberry, dried 1.000000 1.000 1.000 

1307132000 13G Cranberry, juice 1.000000 1.100 1.000 

1307132001 13G Cranberry, juice-babyfood 1.000000 1.100 1.000 

1307359000 13G Strawberry 1.000000 1.000 1.000 

1307359001 13G Strawberry-babyfood 1.000000 1.000 1.000 

1307360000 13G Strawberry, juice 1.000000 1.000 1.000 

1307360001 13G Strawberry, juice-babyfood 1.000000 1.000 1.000 
Fenpyroximate Dietary Exposure and Risk Assessment DP# 405718

_____________________________________________________________________________________________ 

Page 11 of 19

1400003000 14 Almond 0.100000 1.000 1.000 

1400003001 14 Almond-babyfood 0.100000 1.000 1.000 

1400004000 14 Almond, oil 0.100000 1.000 1.000 

1400004001 14 Almond, oil-babyfood 0.100000 1.000 1.000 

1400059000 14 Brazil nut 0.100000 1.000 1.000 

1400068000 14 Butternut 0.100000 1.000 1.000 

1400081000 14 Cashew 0.100000 1.000 1.000 

1400092000 14 Chestnut 0.100000 1.000 1.000 

1400155000 14 Hazelnut 0.100000 1.000 1.000 

1400156000 14 Hazelnut, oil 0.100000 1.000 1.000 

1400185000 14 Hickory nut 0.100000 1.000 1.000 

1400213000 14 Macadamia nut 0.100000 1.000 1.000 

1400269000 14 Pecan 0.100000 1.000 1.000 

1400282000 14 Pistachio 0.100000 1.000 1.000 

1400391000 14 Walnut 0.100000 1.000 1.000 

1500120000 15 Corn, field, flour 0.020000 1.000 1.000 

1500120001 15 Corn, field, flour-babyfood 0.020000 1.000 1.000 

1500121000 15 Corn, field, meal 0.020000 1.000 1.000 

1500121001 15 Corn, field, meal-babyfood 0.020000 1.000 1.000 

1500122000 15 Corn, field, bran 0.020000 1.000 1.000 

1500123000 15 Corn, field, starch 0.020000 1.000 1.000 

1500123001 15 Corn, field, starch-babyfood 0.020000 1.000 1.000 

1500124000 15 Corn, field, syrup 0.020000 1.500 1.000 

1500124001 15 Corn, field, syrup-babyfood 0.020000 1.500 1.000 

1500125000 15 Corn, field, oil 0.050000 1.000 1.000 

1500125001 15 Corn, field, oil-babyfood 0.050000 1.000 1.000 

1500126000 15 Corn, pop 0.020000 1.000 1.000 

2003128000 20C Cottonseed, oil 0.100000 1.000 1.000 

2003128001 20C Cottonseed, oil-babyfood 0.100000 1.000 1.000 

3100044000 31 Beef, meat 0.030000 1.000 1.000 

3100044001 31 Beef, meat-babyfood 0.030000 1.000 1.000 

3100045000 31 Beef, meat, dried 0.030000 1.920 1.000 

3100046000 31 Beef, meat byproducts 0.030000 1.000 1.000 

3100046001 31 Beef, meat byproducts-babyfood 0.030000 1.000 1.000 

3100047000 31 Beef, fat 0.030000 1.000 1.000 

3100047001 31 Beef, fat-babyfood 0.030000 1.000 1.000 

3100048000 31 Beef, kidney 0.250000 1.000 1.000 

3100049000 31 Beef, liver 0.250000 1.000 1.000 

3100049001 31 Beef, liver-babyfood 0.250000 1.000 1.000 

3200169000 32 Goat, meat 0.030000 1.000 1.000 

3200170000 32 Goat, meat byproducts 0.030000 1.000 1.000 

3200171000 32 Goat, fat 0.030000 1.000 1.000 

3200172000 32 Goat, kidney 0.250000 1.000 1.000 

3200173000 32 Goat, liver 0.250000 1.000 1.000 

3300189000 33 Horse, meat 0.030000 1.000 1.000 

3500339000 35 Sheep, meat 0.030000 1.000 1.000 

3500339001 35 Sheep, meat-babyfood 0.030000 1.000 1.000 

3500340000 35 Sheep, meat byproducts 0.030000 1.000 1.000 

3500341000 35 Sheep, fat 0.030000 1.000 1.000 

3500341001 35 Sheep, fat-babyfood 0.030000 1.000 1.000 

3500342000 35 Sheep, kidney 0.250000 1.000 1.000 

3500343000 35 Sheep, liver 0.250000 1.000 1.000 

3600222000 36 Milk, fat 0.015000 1.000 1.000 

3600222001 36 Milk, fat-baby food/infant formu 0.015000 1.000 1.000 

3600223000 36 Milk, nonfat solids 0.015000 1.000 1.000 

3600223001 36 Milk, nonfat solids-baby food/in 0.015000 1.000 1.000 

3600224000 36 Milk, water 0.015000 1.000 1.000 

3600224001 36 Milk, water-babyfood/infant form 0.015000 1.000 1.000 

3600225001 36 Milk, sugar (lactose)-baby food/ 0.015000 1.000 1.000 

8601000000 86A Water, direct, all sources

 110-Uncooked; Fresh or N/S; Cook Meth N/S

 0.043000 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.043000 1.000 1.000 

9500020000 O Avocado 0.150000 1.000 1.000 

9500074000 O Canistel 0.150000 1.000 1.000 

9500177000 O Grape, leaves 1.000000 1.000 1.000 

9500178000 O Grape, raisin 1.000000 2.700 1.000 

9500186000 O Honey 0.100000 1.000 1.000 

9500186001 O Honey-babyfood 0.100000 1.000 1.000 

9500188000 O Hop 10.000000 1.000 1.000 

9500215000 O Mango 0.150000 1.000 1.000 
Fenpyroximate Dietary Exposure and Risk Assessment DP# 405718

_____________________________________________________________________________________________ 

Page 12 of 19

9500215001 O Mango-babyfood 0.150000 1.000 1.000 

9500216000 O Mango, dried 0.150000 1.000 1.000 

9500217000 O Mango, juice 0.150000 1.000 1.000 

9500217001 O Mango, juice-babyfood 0.150000 1.000 1.000 

9500245000 O Papaya 0.150000 1.000 1.000 

9500245001 O Papaya-babyfood 0.150000 1.000 1.000 

9500246000 O Papaya, dried 0.150000 1.800 1.000 

9500247000 O Papaya, juice 0.150000 1.500 1.000 

9500275000 O Peppermint 7.000000 1.000 1.000 

9500276000 O Peppermint, oil 7.000000 0.080 1.000 

9500333000 O Sapote, Mamey 0.150000 1.000 1.000 

9500352000 O Spearmint 7.000000 1.000 1.000 

9500353000 O Spearmint, oil 7.000000 0.080 1.000 

9500372000 O Tea, dried 20.000000 1.000 1.000 

9500373000 O Tea, instant 20.000000 1.000 1.000 
Fenpyroximate Dietary Exposure and Risk Assessment DP# 405718

_____________________________________________________________________________________________ 

Page 13 of 19

Attachment 2: DEEM-FCID Acute Exposure Estimates for Females 13 to 49 Years Old.

EPA Ver. 3.16, 03-08-d

DEEM-FCID ACUTE Analysis for FENPYROXIMATE NHANES 2003-2008 2-Day

Residue file: 129131a.R08 Adjustment factor #2 used.

Analysis Date: 02-01-2013/11:22:40 Residue file dated: 02-01-2013/11:17:00

RAC/FF intake summed over 24 hours

Run Comment: "New uses; added additional acute endpt. for general population"

===============================================================================

Summary calculations--per capita:

 95th Percentile 99th Percentile 99.9th Percentile

 Exposure % aRfD Exposure % aRfD Exposure % aRfD 

 ---------- -------- ---------- -------- ---------- --------

Female 13-49:

 0.006685 13.37 0.010890 21.78 0.018888 37.78 
Fenpyroximate Dietary Exposure and Risk Assessment DP# 405718

_____________________________________________________________________________________________ 

Page 14 of 19

Attachment 3: DEEM-FCID Acute Exposure Estimates for the General U.S. Population 

Subgroups.

EPA Ver. 3.16, 03-08-d

DEEM-FCID ACUTE Analysis for FENPYROXIMATE NHANES 2003-2008 2-Day

Residue file: 129131a.R08 Adjustment factor #2 used.

Analysis Date: 02-01-2013/11:21:36 Residue file dated: 02-01-2013/11:17:00

RAC/FF intake summed over 24 hours

Run Comment: "New uses; added additional acute endpt. for general population"

===============================================================================

Summary calculations--per capita:

 95th Percentile 99th Percentile 99.9th Percentile

 Exposure % aRfD Exposure % aRfD Exposure % aRfD 

 ---------- -------- ---------- -------- ---------- --------

Total US Population:

 0.008312 2.22 0.015331 4.09 0.031367 8.36 

All Infants:

 0.022585 6.02 0.038089 10.16 0.064723 17.26 

Children 1-2:

 0.023191 6.18 0.035415 9.44 0.059443 15.85 

Children 3-5:

 0.016596 4.43 0.023834 6.36 0.041924 11.18 

Children 6-12:

 0.009835 2.62 0.017059 4.55 0.029926 7.98 

Youth 13-19:

 0.005336 1.42 0.009026 2.41 0.018289 4.88 

Adults 20-49:

 0.006565 1.75 0.010483 2.80 0.018315 4.88 

Adults 50-99:

 0.006917 1.84 0.011416 3.04 0.017527 4.67 
Fenpyroximate Dietary Exposure and Risk Assessment DP# 405718

_____________________________________________________________________________________________ 

Page 15 of 19

Attachment 4: DEEM-FCID Chronic Food + Drinking Water Residue Input File.

Filename: C:\Documents and Settings\gkramer\My Documents\Gk\#$Fenpyroximate\129131C.R08

Chemical: Fenpyroximate

RfD(Chronic): .05 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .375 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 02-01-2013/11:15:04 Program ver. 3.16, 03-08-d

Comment: New uses; added additional acute endpt. for general population

-----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

0103015000 1CD Arrowroot, flour 0.100000 1.000 1.000 

0103015001 1CD Arrowroot, flour-babyfood 0.100000 1.000 1.000 

0103017000 1CD Artichoke, Jerusalem 0.100000 1.000 1.000 

0103082000 1CD Cassava 0.100000 1.000 1.000 

0103082001 1CD Cassava-babyfood 0.100000 1.000 1.000 

0103139000 1CD Dasheen, corm 0.100000 1.000 1.000 

0103166000 1CD Ginger 0.100000 1.000 1.000 

0103166001 1CD Ginger-babyfood 0.100000 1.000 1.000 

0103167000 1CD Ginger, dried 0.100000 1.000 1.000 

0103296000 1C Potato, chips 0.100000 1.000 1.000 

0103297000 1C Potato, dry (granules/ flakes) 0.100000 6.500 1.000 

0103297001 1C Potato, dry (granules/ flakes)-b 0.100000 6.500 1.000 

0103298000 1C Potato, flour 0.100000 6.500 1.000 

0103298001 1C Potato, flour-babyfood 0.100000 6.500 1.000 

0103299000 1C Potato, tuber, w/peel 0.100000 1.000 1.000 

0103299001 1C Potato, tuber, w/peel-babyfood 0.100000 1.000 1.000 

0103300000 1C Potato, tuber, w/o peel 0.100000 1.000 1.000 

0103300001 1C Potato, tuber, w/o peel-babyfood 0.100000 1.000 1.000 

0103366000 1CD Sweet potato 0.100000 1.000 1.000 

0103366001 1CD Sweet potato-babyfood 0.100000 1.000 1.000 

0103371000 1CD Tanier, corm 0.100000 1.000 1.000 

0103387000 1CD Turmeric 0.100000 1.000 1.000 

0103406000 1CD Yam, true 0.100000 1.000 1.000 

0103407000 1CD Yam bean 0.100000 1.000 1.000 

0601043000 6A Bean, snap, succulent 0.400000 1.000 1.000 

0601043001 6A Bean, snap, succulent-babyfood 0.400000 1.000 1.000 

0801374000 8A Tomatillo 0.200000 1.000 1.000 

0801375000 8A Tomato 0.200000 1.000 1.000 

0801375001 8A Tomato-babyfood 0.200000 1.000 1.000 

0801376000 8A Tomato, paste 0.200000 1.000 1.000 

0801376001 8A Tomato, paste-babyfood 0.200000 1.000 1.000 

0801377000 8A Tomato, puree 0.200000 1.000 1.000 

0801377001 8A Tomato, puree-babyfood 0.200000 1.000 1.000 

0801378000 8A Tomato, dried 0.200000 14.300 1.000 

0801378001 8A Tomato, dried-babyfood 0.200000 14.300 1.000 

0801379000 8A Tomato, juice 0.200000 1.500 1.000 

0801380000 8A Tomato, Tree 0.200000 1.000 1.000 

0802148000 8BC Eggplant 0.200000 1.000 1.000 

0802234000 8BC Okra 0.200000 1.000 1.000 

0802270000 8B Pepper, bell 0.200000 1.000 1.000 

0802270001 8B Pepper, bell-babyfood 0.200000 1.000 1.000 

0802271000 8B Pepper, bell, dried 0.200000 1.000 1.000 

0802271001 8B Pepper, bell, dried-babyfood 0.200000 1.000 1.000 

0802272000 8BC Pepper, nonbell 0.200000 1.000 1.000 

0802272001 8BC Pepper, nonbell-babyfood 0.200000 1.000 1.000 

0802273000 8BC Pepper, nonbell, dried 0.200000 1.000 1.000 

0901075000 9A Cantaloupe 0.100000 1.000 1.000 

0901187000 9A Honeydew melon 0.100000 1.000 1.000 

0901399000 9A Watermelon 0.100000 1.000 1.000 

0901400000 9A Watermelon, juice 0.100000 1.000 1.000 

0902135000 9B Cucumber 0.400000 1.000 1.000 

1001106000 10A Citron 0.500000 1.000 1.000 

1001107000 10A Citrus hybrids 0.500000 1.000 1.000 

1001108000 10A Citrus, oil 10.000000 1.000 1.000 

1001240000 10A Orange 0.500000 1.000 1.000 

1001241000 10A Orange, juice 0.500000 0.060 1.000 

1001241001 10A Orange, juice-babyfood 0.500000 0.060 1.000 

1001242000 10A Orange, peel 0.500000 1.000 1.000 
Fenpyroximate Dietary Exposure and Risk Assessment DP# 405718

_____________________________________________________________________________________________ 

Page 16 of 19

1001369000 10A Tangerine 0.500000 1.000 1.000 

1001370000 10A Tangerine, juice 0.500000 0.060 1.000 

1002197000 10B Kumquat 0.500000 1.000 1.000 

1002199000 10B Lemon 0.500000 1.000 1.000 

1002200000 10B Lemon, juice 0.500000 0.060 1.000 

1002200001 10B Lemon, juice-babyfood 0.500000 0.060 1.000 

1002201000 10B Lemon, peel 0.500000 1.000 1.000 

1002206000 10B Lime 0.500000 1.000 1.000 

1002207000 10B Lime, juice 0.500000 0.060 1.000 

1002207001 10B Lime, juice-babyfood 0.500000 0.060 1.000 

1003180000 10C Grapefruit 0.500000 1.000 1.000 

1003181000 10C Grapefruit, juice 0.500000 0.060 1.000 

1003307000 10C Pummelo 0.500000 1.000 1.000 

1100007000 11 Apple, fruit with peel 0.300000 1.000 1.000 

1100008000 11 Apple, peeled fruit 0.300000 1.000 1.000 

1100008001 11 Apple, peeled fruit-babyfood 0.300000 1.000 1.000 

1100009000 11 Apple, dried 0.300000 8.000 1.000 

1100009001 11 Apple, dried-babyfood 0.300000 8.000 1.000 

1100010000 11 Apple, juice 0.300000 0.110 1.000 

1100010001 11 Apple, juice-babyfood 0.300000 0.110 1.000 

1100011000 11 Apple, sauce 0.300000 1.000 1.000 

1100011001 11 Apple, sauce-babyfood 0.300000 1.000 1.000 

1100129000 11 Crabapple 0.300000 1.000 1.000 

1100173500 11 Goji berry 0.200000 1.000 1.000 

1100210000 11 Loquat 0.300000 1.000 1.000 

1100266000 11 Pear 0.300000 1.000 1.000 

1100266001 11 Pear-babyfood 0.300000 1.000 1.000 

1100267000 11 Pear, dried 0.300000 6.250 1.000 

1100268000 11 Pear, juice 0.300000 0.110 1.000 

1100268001 11 Pear, juice-babyfood 0.300000 0.110 1.000 

1100310000 11 Quince 0.300000 1.000 1.000 

1201090000 12A Cherry 2.000000 1.000 1.000 

1201090001 12A Cherry-babyfood 2.000000 1.000 1.000 

1201091000 12A Cherry, juice 2.000000 1.500 1.000 

1201091001 12A Cherry, juice-babyfood 2.000000 1.500 1.000 

1202012000 12B Apricot 2.000000 1.000 1.000 

1202012001 12B Apricot-babyfood 2.000000 1.000 1.000 

1202013000 12B Apricot, dried 2.000000 6.000 1.000 

1202014000 12B Apricot, juice 2.000000 1.000 1.000 

1202014001 12B Apricot, juice-babyfood 2.000000 1.000 1.000 

1202230000 12B Nectarine 2.000000 1.000 1.000 

1202260000 12B Peach 2.000000 1.000 1.000 

1202260001 12B Peach-babyfood 2.000000 1.000 1.000 

1202261000 12B Peach, dried 2.000000 7.000 1.000 

1202261001 12B Peach, dried-babyfood 2.000000 7.000 1.000 

1202262000 12B Peach, juice 2.000000 1.000 1.000 

1202262001 12B Peach, juice-babyfood 2.000000 1.000 1.000 

1203285000 12C Plum 2.000000 1.000 1.000 

1203285001 12C Plum-babyfood 2.000000 1.000 1.000 

1203286000 12C Plum, prune, fresh 2.000000 1.000 1.000 

1203286001 12C Plum, prune, fresh-babyfood 2.000000 1.000 1.000 

1203287000 12C Plum, prune, dried 2.000000 1.000 1.000 

1203287001 12C Plum, prune, dried-babyfood 2.000000 1.000 1.000 

1203288000 12C Plum, prune, juice 2.000000 1.400 1.000 

1203288001 12C Plum, prune, juice-babyfood 2.000000 1.400 1.000 

1302057000 13B Blueberry 1.000000 1.000 1.000 

1302057001 13B Blueberry-babyfood 1.000000 1.000 1.000 

1302174000 13B Gooseberry 1.000000 1.000 1.000 

1304175000 13D Grape 1.000000 1.000 1.000 

1304176000 13D Grape, juice 1.000000 0.110 1.000 

1304176001 13D Grape, juice-babyfood 1.000000 0.110 1.000 

1304179000 13D Grape, wine and sherry 1.000000 1.000 1.000 

1307130000 13G Cranberry 1.000000 1.000 1.000 

1307130001 13G Cranberry-babyfood 1.000000 1.000 1.000 

1307131000 13G Cranberry, dried 1.000000 1.000 1.000 

1307132000 13G Cranberry, juice 1.000000 1.100 1.000 

1307132001 13G Cranberry, juice-babyfood 1.000000 1.100 1.000 

1307359000 13G Strawberry 1.000000 1.000 1.000 

1307359001 13G Strawberry-babyfood 1.000000 1.000 1.000 

1307360000 13G Strawberry, juice 1.000000 1.000 1.000 

1307360001 13G Strawberry, juice-babyfood 1.000000 1.000 1.000 
Fenpyroximate Dietary Exposure and Risk Assessment DP# 405718

_____________________________________________________________________________________________ 

Page 17 of 19

1400003000 14 Almond 0.100000 1.000 1.000 

1400003001 14 Almond-babyfood 0.100000 1.000 1.000 

1400004000 14 Almond, oil 0.100000 1.000 1.000 

1400004001 14 Almond, oil-babyfood 0.100000 1.000 1.000 

1400059000 14 Brazil nut 0.100000 1.000 1.000 

1400068000 14 Butternut 0.100000 1.000 1.000 

1400081000 14 Cashew 0.100000 1.000 1.000 

1400092000 14 Chestnut 0.100000 1.000 1.000 

1400155000 14 Hazelnut 0.100000 1.000 1.000 

1400156000 14 Hazelnut, oil 0.100000 1.000 1.000 

1400185000 14 Hickory nut 0.100000 1.000 1.000 

1400213000 14 Macadamia nut 0.100000 1.000 1.000 

1400269000 14 Pecan 0.100000 1.000 1.000 

1400282000 14 Pistachio 0.100000 1.000 1.000 

1400391000 14 Walnut 0.100000 1.000 1.000 

1500120000 15 Corn, field, flour 0.020000 1.000 1.000 

1500120001 15 Corn, field, flour-babyfood 0.020000 1.000 1.000 

1500121000 15 Corn, field, meal 0.020000 1.000 1.000 

1500121001 15 Corn, field, meal-babyfood 0.020000 1.000 1.000 

1500122000 15 Corn, field, bran 0.020000 1.000 1.000 

1500123000 15 Corn, field, starch 0.020000 1.000 1.000 

1500123001 15 Corn, field, starch-babyfood 0.020000 1.000 1.000 

1500124000 15 Corn, field, syrup 0.020000 1.500 1.000 

1500124001 15 Corn, field, syrup-babyfood 0.020000 1.500 1.000 

1500125000 15 Corn, field, oil 0.050000 1.000 1.000 

1500125001 15 Corn, field, oil-babyfood 0.050000 1.000 1.000 

1500126000 15 Corn, pop 0.020000 1.000 1.000 

2003128000 20C Cottonseed, oil 0.100000 1.000 1.000 

2003128001 20C Cottonseed, oil-babyfood 0.100000 1.000 1.000 

3100044000 31 Beef, meat 0.030000 1.000 1.000 

3100044001 31 Beef, meat-babyfood 0.030000 1.000 1.000 

3100045000 31 Beef, meat, dried 0.030000 1.920 1.000 

3100046000 31 Beef, meat byproducts 0.030000 1.000 1.000 

3100046001 31 Beef, meat byproducts-babyfood 0.030000 1.000 1.000 

3100047000 31 Beef, fat 0.030000 1.000 1.000 

3100047001 31 Beef, fat-babyfood 0.030000 1.000 1.000 

3100048000 31 Beef, kidney 0.250000 1.000 1.000 

3100049000 31 Beef, liver 0.250000 1.000 1.000 

3100049001 31 Beef, liver-babyfood 0.250000 1.000 1.000 

3200169000 32 Goat, meat 0.030000 1.000 1.000 

3200170000 32 Goat, meat byproducts 0.030000 1.000 1.000 

3200171000 32 Goat, fat 0.030000 1.000 1.000 

3200172000 32 Goat, kidney 0.250000 1.000 1.000 

3200173000 32 Goat, liver 0.250000 1.000 1.000 

3300189000 33 Horse, meat 0.030000 1.000 1.000 

3500339000 35 Sheep, meat 0.030000 1.000 1.000 

3500339001 35 Sheep, meat-babyfood 0.030000 1.000 1.000 

3500340000 35 Sheep, meat byproducts 0.030000 1.000 1.000 

3500341000 35 Sheep, fat 0.030000 1.000 1.000 

3500341001 35 Sheep, fat-babyfood 0.030000 1.000 1.000 

3500342000 35 Sheep, kidney 0.250000 1.000 1.000 

3500343000 35 Sheep, liver 0.250000 1.000 1.000 

3600222000 36 Milk, fat 0.015000 1.000 1.000 

3600222001 36 Milk, fat-baby food/infant formu 0.015000 1.000 1.000 

3600223000 36 Milk, nonfat solids 0.015000 1.000 1.000 

3600223001 36 Milk, nonfat solids-baby food/in 0.015000 1.000 1.000 

3600224000 36 Milk, water 0.015000 1.000 1.000 

3600224001 36 Milk, water-babyfood/infant form 0.015000 1.000 1.000 

3600225001 36 Milk, sugar (lactose)-baby food/ 0.015000 1.000 1.000 

8601000000 86A Water, direct, all sources

 110-Uncooked; Fresh or N/S; Cook Meth N/S

 0.008600 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.008600 1.000 1.000 

9500020000 O Avocado 0.150000 1.000 1.000 

9500074000 O Canistel 0.150000 1.000 1.000 

9500177000 O Grape, leaves 1.000000 1.000 1.000 

9500178000 O Grape, raisin 1.000000 2.700 1.000 

9500186000 O Honey 0.100000 1.000 1.000 

9500186001 O Honey-babyfood 0.100000 1.000 1.000 

9500188000 O Hop 10.000000 1.000 1.000 

9500215000 O Mango 0.150000 1.000 1.000 
Fenpyroximate Dietary Exposure and Risk Assessment DP# 405718

_____________________________________________________________________________________________ 

Page 18 of 19

9500215001 O Mango-babyfood 0.150000 1.000 1.000 

9500216000 O Mango, dried 0.150000 1.000 1.000 

9500217000 O Mango, juice 0.150000 1.000 1.000 

9500217001 O Mango, juice-babyfood 0.150000 1.000 1.000 

9500245000 O Papaya 0.150000 1.000 1.000 

9500245001 O Papaya-babyfood 0.150000 1.000 1.000 

9500246000 O Papaya, dried 0.150000 1.800 1.000 

9500247000 O Papaya, juice 0.150000 1.500 1.000 

9500275000 O Peppermint 7.000000 1.000 1.000 

9500276000 O Peppermint, oil 7.000000 0.080 1.000 

9500333000 O Sapote, Mamey 0.150000 1.000 1.000 

9500352000 O Spearmint 7.000000 1.000 1.000 

9500353000 O Spearmint, oil 7.000000 0.080 1.000 

9500372000 O Tea, dried 20.000000 1.000 1.000 

9500373000 O Tea, instant 20.000000 1.000 1.000 
Fenpyroximate Dietary Exposure and Risk Assessment DP# 405718

_____________________________________________________________________________________________ 

Page 19 of 19

Attachment 5: DEEM-FCID Chronic Exposure Estimates.

EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for FENPYROXIMATE NHANES 2003-2008 2-day

Residue file name: C:\Documents and Settings\gkramer\My Documents\Gk\#$Fenpyroximate\129131C.R08

 Adjustment factor #2 used.

Analysis Date 02-01-2013/11:19:11 Residue file dated: 02-01-2013/11:15:04

Reference dose (RfD, Chronic) = .05 mg/kg bw/day

COMMENT 1: New uses; added additional acute endpt. for general population

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ----------------

Total US Population 0.002208 4.4%

Hispanic 0.002196 4.4%

Non-Hisp-White 0.002285 4.6%

Non-Hisp-Black 0.001775 3.5%

Non-Hisp-Other 0.002235 4.5%

Nursing Infants 0.003063 6.1%

Non-Nursing Infants 0.005431 10.9%

Female 13+ PREG 0.001848 3.7%

Children 1-6 0.005749 11.5%

Children 7-12 0.002458 4.9%

Male 13-19 0.001337 2.7%

Female 13-19/NP 0.001458 2.9%

Male 20+ 0.001755 3.5%

Female 20+/NP 0.001911 3.8%

Seniors 55+ 0.002081 4.2%

All Infants 0.004700 9.4%

Female 13-50 0.001695 3.4%

Children 1-2 0.007336 14.7%

Children 3-5 0.005098 10.2%

Children 6-12 0.002723 5.4%

Youth 13-19 0.001394 2.8%

Adults 20-49 0.001712 3.4%

Adults 50-99 0.002013 4.0%

Female 13-49 0.001693 3.4%

-------------------------------------------------------------------------------