EX-10.2



 Exhibit 10.2 
  

 
  

 
  

 
 INVESTOR RIGHTS
AGREEMENT 
 BY AND AMONG 

OREXIGEN THERAPEUTICS, INC., 

BAUPOST GROUP SECURITIES, L.L.C., 

AND 
 THE OTHER
INVESTORS PARTY HERETO 
 DATED AS OF MARCH 15, 2016 

 
  

 







 TABLE OF CONTENTS 

 

									
	 ARTICLE I EFFECTIVENESS
	  	 	1	  
		 	 Section 1.1.
	    	 Effectiveness
	  	 	1	  
		
	 ARTICLE II DEFINITIONS
	  	 	1	  
		 	 Section 2.1.
	    	 Definitions
	  	 	1	  
		 	 Section 2.2.
	    	 Other Interpretive Provisions
	  	 	5	  
		
	 ARTICLE III REGISTRATION RIGHTS
	  	 	6	  
		 	 Section 3.1.
	    	 Demand Registration
	  	 	6	  
		 	 Section 3.2.
	    	 Shelf Registration
	  	 	8	  
		 	 Section 3.3.
	    	 Piggyback Registration
	  	 	11	  
		 	 Section 3.4.
	    	 Lock-Up Agreements
	  	 	12	  
		 	 Section 3.5.
	    	 Registration Procedures
	  	 	13	  
		 	 Section 3.6.
	    	 Underwritten Offerings
	  	 	18	  
		 	 Section 3.7.
	    	 No Inconsistent Agreements; Additional Rights
	  	 	19	  
		 	 Section 3.8.
	    	 Registration Expenses
	  	 	20	  
		 	 Section 3.9.
	    	 Indemnification
	  	 	20	  
		 	 Section 3.10.
	    	 Rules 144 and 144A and Regulation S
	  	 	23	  
		 	 Section 3.11.
	    	 Existing Registration Statements
	  	 	23	  
		
	 ARTICLE IV GOVERNANCE
	  	 	24	  
		 	 Section 4.1.
	    	 Composition of the Board of Directors
	  	 	24	  
		
	 ARTICLE V MISCELLANEOUS
	  	 	25	  
		 	 Section 5.1.
	    	 Authority; Effect
	  	 	25	  
		 	 Section 5.2.
	    	 Notices
	  	 	26	  
		 	 Section 5.3.
	    	 Termination and Effect of Termination
	  	 	27	  
		 	 Section 5.4.
	    	 Permitted Transferees
	  	 	27	  
		 	 Section 5.5.
	    	 Remedies
	  	 	27	  
		 	 Section 5.6.
	    	 Amendments
	  	 	27	  
		 	 Section 5.7.
	    	 Governing Law
	  	 	28	  
		 	 Section 5.8.
	    	 Consent to Jurisdiction
	  	 	28	  
		 	 Section 5.9.
	    	 WAIVER OF JURY TRIAL
	  	 	28	  
		 	 Section 5.10.
	    	 Merger; Binding Effect, Etc.
	  	 	29	  
		 	 Section 5.11.
	    	 Counterparts
	  	 	29	  
		 	 Section 5.12
	    	 Severability
	  	 	29	  
		 	 Section 5.13.
	    	 No Recourse
	  	 	29	  


  
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 This INVESTOR RIGHTS AGREEMENT (as it may be amended from time to time in accordance with the
terms hereof, the “Agreement”), dated as of March 15, 2016, is made by and among: 
 i. Orexigen Therapeutics, Inc., a
Delaware corporation (the “Company”); 
 ii. Baupost Group Securities, L.L.C. (together with its Permitted Transferees that
become party hereto, “Baupost”); and 
 iii. Such other investors as set forth on Schedule A (each, together with its
Permitted Transferees that become party hereto, an “Other Investor”, collectively, the “Other Investors”, and, collectively with Baupost, the “Investors” and each individually, an
“Investor”). 
 RECITALS 

WHEREAS, pursuant to the Securities Purchase Agreement dated March 15, 2016 among the Company, Baupost, and the Other Investors (the
“Purchase Agreement”), Baupost and the Other Investors are purchasing $150 million aggregate principal amount of 0% Senior Secured Convertible Notes due 2020 (the “Notes”) which will be convertible into cash and
under certain circumstances, into shares of common stock of the Company, par value $0.001 per share (“Common Stock”); and 

WHEREAS, the parties believe that it is in the best interests of the Company and the other parties hereto to set forth their agreements
regarding registration and other rights. 
 NOW, THEREFORE, in consideration of the foregoing and the mutual promises, covenants and
agreements of the parties hereto, and for other good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the parties hereto agree as follows: 

ARTICLE I 

EFFECTIVENESS 

Section 1.1. Effectiveness. This Agreement shall become effective upon the signing of the Purchase Agreement. 

ARTICLE II 
 DEFINITIONS

 Section 2.1. Definitions. As used in this Agreement, the following terms shall have the following meanings:

 “Adverse Disclosure” means public disclosure of material non-public information that, in the good faith judgment of the
board of directors of the Company: (i) would be required to be made in any Registration Statement filed with the SEC by the Company so that such Registration Statement, from and after its effective date, does not contain an untrue statement of a
material 







 
fact or omit to state a material fact required to be stated therein or necessary to make the statements therein not misleading; (ii) would not be required to be made at such time but for the
filing, effectiveness or continued use of such Registration Statement; and (iii) the Company has a bona fide business purpose for not disclosing publicly. 

“Affiliate” means, with respect to any specified Person, (a) any Person that directly or indirectly through one or more
intermediaries controls, or is controlled by, or is under common control with, such specified Person (b) in the event that the specified Person is a natural Person, a Member of the Immediate Family of such Person or (c) any investment fund advised
or managed by, or under common control or management with, such person; provided that the Company and each of its subsidiaries shall be deemed not to be Affiliates of any Investor. As used in this definition, the term “control”
means the possession, directly or indirectly, of the power to direct or cause the direction of the management and policies of a Person, whether through ownership of voting securities, by contract or otherwise. 

“Agreement” shall have the meaning set forth in the preamble. 

“Annual Meeting” shall have the meaning set forth in Section 4.1. 

“Baupost” shall have the meaning set forth in the preamble. 

“Baupost Designee” shall have the meaning set forth in Section 4.1. 

“Baupost Observer” shall have the meaning set forth in Section 4.1. 

“Board” shall have the meaning set forth in Section 4.1. 

“Business Day” means any day that is not a Saturday, a Sunday or other day on which banks are required or authorized by law
to be closed in the City of New York. 
 “Common Stock” shall have the meaning set forth in the recitals. 

“Demand Registration” shall have the meaning set forth in Section 3.1.1(a). 

“Demand Registration Request” shall have the meaning set forth in Section 3.1.1(a). 

“Demand Registration Statement” shall have the meaning set forth in Section 3.1.1(c). 

“Demand Suspension” shall have the meaning set forth in Section 3.1.6. 

“Exchange Act” means the Securities Exchange Act of 1934, as amended, and any successor thereto, and any rules and
regulations promulgated thereunder, all as the same shall be in effect from time to time. 
 “FINRA” means the Financial
Industry Regulatory Authority. 
 “Holder” means the Investors who then hold Registrable Securities under this Agreement.


  
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 “Indenture” means the indenture, to be dated on or about March 21, 2016, by and
among the Company and the Trustee, pursuant to which the Notes are to be issued, as such Indenture is amended or supplemented from time to time in accordance with the terms thereof. 

“Investor” shall have the meaning set forth in the preamble. 

“Issuer Free Writing Prospectus” means an issuer free writing prospectus, as defined in Rule 433 under the Securities
Act, relating to an offer of the Registrable Securities. 
 “Loss” shall have the meaning set forth in Section 3.9.1. 

“Member of the Immediate Family” means, with respect to any Person who is an individual, (a) each parent, spouse (but not
including a former spouse or a spouse from whom such Person is legally separated) or child (including those adopted) of such individual and (b) each trustee, solely in his or her capacity as trustee, for a trust naming only one or more of the
Persons listed in sub-clause (a) as beneficiaries. 
 “Notes” shall have the meaning set forth in the recitals. 

“Other Investor” shall have the meaning set forth in the preamble. 

“Permitted Transferee” means, with respect to any Investor (i) any Affiliate of such Investor (ii) any other Person to whom
such Investor Transfers Registrable Securities in exchange for proceeds of at least $3,000,000 and (iii) any custodian or nominee that holds Registrable Securities for the account of such Investor or any Permitted Transferee described in clause (i)
or (ii). 
 “Person” means any individual, partnership, corporation, company, association, trust, joint venture, limited
liability company, unincorporated organization, entity or division, or any government, governmental department or agency or political subdivision thereof. 

“Piggyback Notice” shall have the meaning set forth in Section 3.3.1. 

“Piggyback Registration” shall have the meaning set forth in Section 3.3.1. 

“Pro Rata Portion” means, with respect to each Holder requesting that its shares be registered or sold in an Underwritten
Public Offering, a number of such shares equal to the aggregate number of Registrable Securities to be registered or sold (excluding any shares to be registered or sold for the account of the Company) multiplied by a fraction, the numerator of which
is the aggregate number of Registrable Securities held by such Holder, and the denominator of which is the aggregate number of Registrable Securities held by all Holders requesting that their Registrable Securities be registered or sold. 

“Prospectus” means (i) the prospectus included in any Registration Statement, all amendments and supplements to such
prospectus, including post-effective amendments and supplements, and all other material incorporated by reference in such prospectus, and (ii) any Issuer Free Writing Prospectus. 

  
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 “Public Offering” means the offer and sale of Registrable Securities for cash
pursuant to an effective Registration Statement under the Securities Act (other than a Registration Statement on Form S-4 or Form S-8 or any successor form). 

“Purchase Agreement” shall have the meaning set forth in the preamble. 

“Registrable Securities” means (i) all shares of Common Stock that are not then subject to forfeiture to the Company, (ii)
all shares of Common Stock issuable upon exercise, conversion or exchange of any option, warrant or convertible security not then subject to vesting or forfeiture to the Company and (iii) all shares of Common Stock directly or indirectly issued or
then issuable with respect to the securities referred to in clauses (i) or (ii) above by way of a stock dividend or stock split, or in connection with a combination of shares, recapitalization, merger, consolidation or other reorganization. For
the avoidance of doubt, shares of Common Stock that are not issuable upon conversion of the Notes unless and until Stockholder Approval is obtained shall not be considered Registrable Securities unless and until Stockholder Approval is
obtained. As to any particular Registrable Securities, such securities shall cease to be Registrable Securities when (w) a Registration Statement with respect to the sale of such securities shall have become effective under the Securities Act
and such securities shall have been disposed of in accordance with such Registration Statement, (x) such securities shall have been Transferred pursuant to Rule 144, (y) such holder is able to immediately sell such securities under Rule 144 without
any restrictions on transfer (including without application of paragraphs (c), (d), (e), (f) and (h) of Rule 144), as reasonably determined by the Holder, or (z) such securities shall have ceased to be outstanding. 

“Registration” means registration under the Securities Act of the offer and sale to the public of any Registrable Securities
under a Registration Statement. The terms “register”, “registered” and “registering” shall have correlative meanings. 

“Registration Expenses” shall have the meaning set forth in Section 3.8. 

“Registration Statement” means any registration statement of the Company filed with, or to be filed with, the SEC under the
Securities Act, including the related Prospectus, amendments and supplements to such registration statement, including pre- and post-effective amendments, and all exhibits and all material incorporated by reference in such registration statement
other than a registration statement (and related Prospectus) filed on Form S-4 or Form S-8 or any successor form thereto. 

“Representatives” means, with respect to any Person, any of such Person’s officers, directors, employees, agents,
attorneys, accountants, actuaries, consultants, equity financing partners or financial advisors or other Person associated with, or acting on behalf of, such Person. 

“Requisite Investors” means the holders of at least fifteen percent (15%) of the Registrable Securities issued or issuable
upon conversion of the Notes then held by the Investors. 
 “Rule 144” means Rule 144 under the Securities Act (or any
successor rule). 

  
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 “SEC” means the Securities and Exchange Commission or any successor agency
having jurisdiction under the Securities Act. 
 “Securities Act” means the Securities Act of 1933, as amended, and any
successor thereto, and any rules and regulations promulgated thereunder, all as the same shall be in effect from time to time. 

“Selling Stockholder Information” shall have the meaning set forth in Section 3.9.1. 

“Shelf Period” shall have the meaning set forth in Section 3.2.3. 

“Shelf Registration” shall have the meaning set forth in Section 3.2.1(a). 

“Shelf Registration Request” shall have the meaning set forth in Section 3.2.1(a). 

“Shelf Registration Statement” shall have the meaning set forth in Section 3.2.1(a). 

“Shelf Suspension” shall have the meaning set forth in Section 3.2.4. 

“Shelf Takedown Request” shall have the meaning set forth in Section 3.2.5(a). 

“Stockholder Approval” has the meaning ascribed to it in the Purchase Agreement. 

“Transfer” means, with respect to any Registrable Security, any interest therein, or any other securities or equity interests
relating thereto, a direct or indirect transfer, sale, exchange, assignment, pledge, hypothecation or other encumbrance or other disposition thereof, including the grant of an option or other right, whether directly or indirectly, whether
voluntarily, involuntarily, by operation of law, pursuant to judicial process or otherwise. “Transferred” shall have a correlative meaning. 

“Trustee” means U.S. Bank National Association 

“Underwritten Public Offering” means an underwritten Public Offering, including any bought deal or block sale to a financial
institution conducted as an underwritten Public Offering. 
 “Underwritten Shelf Takedown” means an Underwritten Public
Offering pursuant to an effective Shelf Registration Statement. 
 “WKSI” means any Securities Act registrant that is a
well-known seasoned issuer as defined in Rule 405 under the Securities Act at the most recent eligibility determination date specified in paragraph (2) of that definition. 

Section 2.2. Other Interpretive Provisions. 

(a) The meanings of defined terms are equally applicable to the singular and plural forms of the defined terms. 

  
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 (b) The words “hereof”, “herein”, “hereunder” and similar words
refer to this Agreement as a whole and not to any particular provision of this Agreement; and any subsection and section references are to this Agreement unless otherwise specified. 

(c) The term “including” is not limiting and means “including without limitation.” 

(d) The captions and headings of this Agreement are for convenience of reference only and shall not affect the interpretation of this
Agreement. 
 (e) Whenever the context requires, any pronouns used herein shall include the corresponding masculine, feminine or neuter
forms. 
 ARTICLE III 

REGISTRATION RIGHTS
 The
Company will perform and comply, and cause each of its subsidiaries to perform and comply, with such of the following provisions as are applicable to it. Each Holder will perform and comply with such of the following provisions as are
applicable to such Holder. 
 Section 3.1. Demand Registration.

Section 3.1.1. Request for Demand Registration. 

 

	(a)	At any time after the date hereof, either (i) Baupost or (ii) the Requisite Investors shall have the right to make a written request from time to time (a “Demand Registration Request”) to the Company
for Registration of all or part of the Registrable Securities held by such Investors. Any such Registration pursuant to a Demand Registration Request shall hereinafter be referred to as a “Demand Registration.” 


 

	(b)	Each Demand Registration Request shall specify (x) the kind and aggregate amount of Registrable Securities to be registered, and (y) the intended method or methods of disposition thereof. 


 

	(c)	Upon receipt of a Demand Registration Request, the Company shall as promptly as practicable file a Registration Statement (a “Demand Registration Statement”) relating to such Demand Registration, and
use its reasonable best efforts to cause such Demand Registration Statement to be promptly declared effective under the Securities Act. 


Section 3.1.2. Limitation on Demand Registrations. The Company shall not be obligated to take any action to
effect any Demand Registration requested by Baupost if (x) an Underwritten Public Offering pursuant to Section 3.1.1(a)(i) or an Underwritten Shelf Takedown pursuant to Section 3.2.4(a)(i) was consummated within the preceding one hundred eighty
(180) days, or (y) the minimum anticipated proceeds for such Underwritten Public Offering or Underwritten Shelf Takedown are not at least $20 million (unless otherwise consented to by the Company). The Company shall not be obligated to take any
action to effect any Demand Registration requested by the Requisite Investors if, at the request of such Requisite Investors (x) an Underwritten Public 

  
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Offering pursuant to Section 3.1.1(a)(ii) or an Underwritten Shelf Takedown pursuant to Section 3.2.4(a)(ii) was consummated within the preceding three hundred sixty five (365) days (unless
otherwise consented to by the Company) or (y) the minimum anticipated proceeds for such Underwritten Public Offering or Underwritten Shelf Takedown are not at least $20 million (unless otherwise consented to by the Company). 

Section 3.1.3. Demand Notice. Promptly upon receipt of a Demand Registration Request pursuant to Section 3.1.1 (but in
no event more than two (2) Business Days thereafter), the Company shall deliver a written notice (a “Demand Notice”) of any such Demand Registration Request to all other Holders and the Demand Notice shall offer each such Holder the
opportunity to include in the Demand Registration that number of Registrable Securities as each such Holder may request in writing. Subject to Section 3.1.7, the Company shall include in the Demand Registration all such Registrable Securities with
respect to which the Company has received written requests for inclusion therein within three (3) Business Days after the date that the Demand Notice was delivered. 

Section 3.1.4. Demand Withdrawal. Any Investor may withdraw all or any portion of its Registrable Securities
included in a Demand Registration from such Demand Registration at any time prior to the effectiveness of the applicable Demand Registration Statement. Upon receipt of a notice to such effect from the Investors with respect to all of the
Registrable Securities included in such Demand Registration, the Company shall cease all efforts to secure effectiveness of the applicable Demand Registration Statement and such Demand Registration shall not count as such pursuant to Section 3.1.2
above. 
 Section 3.1.5. Effective Registration. The Company shall use reasonable best efforts to cause
the Demand Registration Statement to become effective and remain effective for not less than one hundred eighty (180) days (or such shorter period as will terminate when all Registrable Securities covered by such Demand Registration Statement have
been sold or withdrawn), or, if such Demand Registration Statement relates to an Underwritten Public Offering, such longer period as in the opinion of counsel for the underwriter or underwriters a Prospectus is required by law to be delivered in
connection with sales of Registrable Securities by an underwriter or dealer. 
 Section 3.1.6. Delay in Filing; Suspension
of Registration. If the filing, initial effectiveness or continued use of a Demand Registration Statement at any time would require the Company to make an Adverse Disclosure, the Company may, upon giving prompt written notice of such
action to the Holders, delay the filing or initial effectiveness of, or suspend use of, the Demand Registration Statement (a “Demand Suspension”); provided, however, that the Company shall not be permitted to exercise
a Demand Suspension more than twice during any twelve (12)-month period or for a period exceeding thirty (30) days or during the period from January 1, 2020 to July 1, 2020. In the case of a Demand Suspension, the Holders agree to use
their best efforts to suspend use of the applicable Prospectus in connection with any sale or purchase, or offer to sell or purchase, Registrable Securities, upon receipt of the notice referred to above. The Company shall immediately notify the
Holders in writing upon the termination of any 

  
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Demand Suspension, amend or supplement the Prospectus, if necessary, so it does not contain any untrue statement or omission and furnish to the Holders such numbers of copies of the Prospectus as
so amended or supplemented as the Holders may reasonably request. The Company shall, if necessary, supplement or amend the Demand Registration Statement, if required by the registration form used by the Company for the Demand Registration or by
the instructions applicable to such registration form or by the Securities Act or the rules or regulations promulgated thereunder or as may reasonably be requested by the Holders of a majority of Registrable Securities that are included in such
Demand Registration Statement. 
 Section 3.1.7. Priority of Securities Registered Pursuant to Demand
Registrations. If the managing underwriter or underwriters of a proposed Underwritten Public Offering of the Registrable Securities included in a Demand Registration advise the Company in writing that, in its or their opinion, the number of
securities requested to be included in such Demand Registration exceeds the number that can be sold in such offering without being likely to have an adverse effect on the price, timing or distribution of the securities offered or the market for the
securities offered, then the securities to be included in such Registration shall be, in the case of any Demand Registration, (x) first, allocated to each Holder that has requested to participate in such Demand Registration an amount equal to the
lesser of (i) the number of such Registrable Securities requested to be registered or sold by such Holders, and (ii) a number of such shares equal to such Holder’s Pro Rata Portion, and (y) second, and only if all the securities referred to in
clause (x) have been included, the number of other securities that, in the opinion of such managing underwriter or underwriters can be sold without having such adverse effect. 

Section 3.1.8. Resale Rights. In the event that Baupost or any Other Investor requests to participate in a
Registration pursuant to this Section 3.1 in connection with a distribution of Registrable Securities to its partners or members, the Registration shall provide for resale by such partners or members, if requested by such Investor. 

Section 3.2. Shelf Registration. 

Section 3.2.1. Request for Shelf Registration. 
  


	(a)	Upon the written request of Baupost or the Requisite Investors from time to time (a “Shelf Registration Request”), the Company shall promptly file with the SEC a shelf Registration Statement pursuant to
Rule 415 under the Securities Act (“Shelf Registration Statement”) relating to the offer and sale of Registrable Securities requested to be included therein by any Holders thereof from time to time in accordance with the
methods of distribution elected by such Holders, and the Company shall use its reasonable best efforts to cause such Shelf Registration Statement to promptly become effective under the Securities Act. Any such Registration pursuant to a Shelf
Registration Request shall hereinafter be referred to as a “Shelf Registration”. 

  

	(b)	 If on the date of the Shelf Registration Request the Company is a WKSI, then the Shelf Registration Request may request Registration of an unspecified
amount of Registrable Securities to be sold by unspecified Holders. If on the date of the Shelf Registration 



  
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Request the Company is not a WKSI, then the Shelf Registration Request shall specify the aggregate amount of Registrable Securities to be registered. The Company shall provide to the Investors
the information necessary to determine the Company’s status as a WKSI upon request. 

 Section 3.2.2.
Shelf Registration Notice. Promptly upon receipt of a Shelf Registration Request (but in no event more than two (2) Business Days thereafter (or such shorter period as may be reasonably requested in connection with an underwritten “block
trade”)), the Company shall deliver a written notice (a “Shelf Registration Notice”) of any such request to all other Holders, which notice shall specify, if applicable, the amount of Registrable Securities to be registered,
and the Shelf Registration Notice shall offer each such Holder the opportunity to include in the Shelf Registration that number of Registrable Securities as each such Holder may request in writing. The Company shall include in such Shelf
Registration all such Registrable Securities with respect to which the Company has received written requests for inclusion therein within three (3) Business Days (or such shorter period as may be reasonably requested in connection with an
underwritten “block trade”) after the date that the Shelf Registration Notice has been delivered. 
 Section 3.2.3.
Continued Effectiveness. The Company shall use its reasonable best efforts to keep such Shelf Registration Statement continuously effective under the Securities Act in order to permit the Prospectus forming part of the Shelf Registration
Statement to be usable by the Holders until the earlier of: (i) the date as of which all Registrable Securities have been sold pursuant to the Shelf Registration Statement or another Registration Statement filed under the Securities Act (but in
no event prior to the applicable period referred to in Section 4(a)(3) of the Securities Act and Rule 174 thereunder); and (ii) the date as of which no Holder holds Registrable Securities (such period of effectiveness, the “Shelf
Period”). Subject to Section 3.2.3, the Company shall be deemed not to have used its reasonable best efforts to keep the Shelf Registration Statement effective during the Shelf Period if the Company voluntarily takes any action or omits to
take any action that would result in the Holders of the Registrable Securities covered thereby not being able to offer and sell any Registrable Securities pursuant to such Shelf Registration Statement during the Shelf Period, unless such action or
omission is required by applicable law. 
 Section 3.2.4. Suspension of Registration. If the continued use
of such Shelf Registration Statement at any time would require the Company to make an Adverse Disclosure, the Company may, upon giving prompt written notice of such action to the Holders, suspend use of the Shelf Registration Statement (a
“Shelf Suspension”); provided, however, that the Company shall not be permitted to exercise a Shelf Suspension more than twice during any twelve (12)-month period or for a period exceeding thirty (30) days for each
Shelf Suspension or during the period from January 1, 2020 to July 1, 2020. In the case of a Shelf Suspension, the Holders agree to use their best efforts to suspend use of the applicable Prospectus in connection with any sale or
purchase of, or offer to sell or purchase, Registrable Securities, upon receipt of the notice referred to above. The Company shall immediately notify the Holders in writing upon the termination of any Shelf Suspension, amend or supplement the
Prospectus, if 

  
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necessary, so it does not contain any untrue statement or omission and furnish to the Holders such numbers of copies of the Prospectus as so amended or supplemented as the Holders may reasonably
request. The Company shall, if necessary, supplement or amend the Shelf Registration Statement, if required by the registration form used by the Company for the Shelf Registration Statement or by the instructions applicable to such registration
form or by the Securities Act or the rules or regulations promulgated thereunder or as may reasonably be requested by the Holders of a majority of Registrable Securities that are included in such Shelf Registration Statement. 

Section 3.2.5. Shelf Takedown. 
  

	(a)	At any time the Company has an effective Shelf Registration Statement with respect to a Holder’s Registrable Securities, by notice to the Company specifying the intended method or methods of disposition thereof,
either (i) Baupost or (ii) the Requisite Investors may make a written request (a “Shelf Takedown Request”) to the Company to effect a Public Offering, including an Underwritten Shelf Takedown, of all or a portion of such
Holder’s Registrable Securities that may be registered under such Shelf Registration Statement, and as soon as practicable the Company shall amend or supplement the Shelf Registration Statement as necessary for such purpose. 


 

	(b)	Promptly upon receipt of a Shelf Takedown Request (but in no event more than two (2) Business Days thereafter (or such shorter period as maybe reasonably requested in connection with an underwritten “block
trade”)) for any Underwritten Shelf Takedown, the Company shall deliver a notice (a “Shelf Takedown Notice”) to each other Holder with Registrable Securities covered by the applicable Registration Statement, or to all other
Holders if such Registration Statement is undesignated (each a “Potential Takedown Participant”). The Shelf Takedown Notice shall offer each such Potential Takedown Participant the opportunity to include in any Underwritten Shelf Takedown
such number of Registrable Securities as each such Potential Takedown Participant may request in writing. Subject to Section 3.2.6., the Company shall include in the Underwritten Shelf Takedown all such Registrable Securities with respect to which
the Company has received written requests for inclusion therein within three (3) Business Days (or such shorter period as may be reasonably requested in connection with an underwritten “block trade”) after the date that the Shelf Takedown
Notice has been delivered. Notwithstanding the delivery of any Shelf Takedown Notice, all determinations as to whether to complete any Underwritten Shelf Takedown and as to the timing, manner, price and other terms of any Underwritten Shelf Takedown
contemplated by this Section 3.2.5 shall be determined by the participating Requisite Investors. 

  

	(c)	 The Company shall not be obligated to take any action to effect any Underwritten Shelf Takedown requested by Baupost if (x) an Underwritten Public
Offering pursuant to Section 3.1.1(a)(i) or an Underwritten Shelf Takedown pursuant to Section 3.2.4(a)(i) was consummated within the preceding one hundred eighty (180) days, or (y) the minimum anticipated proceeds for such Underwritten Public
Offering or Underwritten Shelf Takedown are not at least $20 million (unless otherwise consented to by the Company). The Company shall not be obligated to take any action to effect any Underwritten Shelf Takedown requested by the Requisite
Investors if, at the request of 



  
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such Requisite Investors (x) an Underwritten Public Offering pursuant to Section 3.1.1(a)(ii) or an Underwritten Shelf Takedown pursuant to Section 3.2.4(a)(ii) was consummated within the
preceding three hundred sixty five (365) days (unless otherwise consented to by the Company) or (y) the minimum anticipated proceeds for such Underwritten Public Offering or Underwritten Shelf Takedown are not at least $20 million (unless otherwise
consented to by the Company). 

 Section 3.2.6. Priority of Securities Sold Pursuant to Shelf
Takedowns. If the managing underwriter or underwriters of a proposed Underwritten Shelf Takedown pursuant to Section 3.2.4 advise the Company in writing that, in its or their opinion, the number of securities requested to be included in the
proposed Underwritten Shelf Takedown exceeds the number that can be sold in such Underwritten Shelf Takedown without being likely to have an adverse effect on the price, timing or distribution of the securities offered or the market for the
securities offered, the number of Registrable Securities to be included in such offering shall be (x) first, allocated to each Holder that has requested to participate in such Underwritten Shelf Takedown an amount equal to the lesser of (i) the
number of such Registrable Securities requested to be registered or sold by such Holder, and (ii) a number of such shares equal to such Holder’s Pro Rata Portion, and (y) second, and only if all the securities referred to in clause (x) have
been included, the number of other securities that, in the opinion of such managing underwriter or underwriters can be sold without having such adverse effect. 

Section 3.2.7. Resale Rights. In the event that Baupost or any Other Investor elects to request a Registration pursuant
to this Section 3.2 in connection with a distribution of Registrable Securities to its partners or members, the Registration shall provide for resale by such partners or members, if requested by such Investor. 

Section 3.3. Piggyback Registration. 

Section 3.3.1. Participation. If the Company at any time proposes to file a Registration Statement under the
Securities Act or to conduct a Public Offering with respect to any offering of its equity securities for its own account or for the account of any other Persons (other than (i) a Registration under Sections 3.1 or 3.2, (ii) a Registration
on Form S-4 or Form S-8 or any successor form to such forms, (iii) a Registration of securities solely relating to an offering and sale to employees or directors of the Company or its subsidiaries pursuant to any employee stock plan or other
employee benefit plan arrangement and (iv) an unallocated shelf Registration on Form S-3 filed on or about the date hereof), then, as soon as practicable (but in no event less than ten (10) Business Days prior to the proposed date of filing of such
Registration Statement or, in the case of a Public Offering under a Shelf Registration Statement, the anticipated pricing or trade date), the Company shall give written notice (a “Piggyback Notice”) of such proposed filing or Public
Offering to all Holders, and such Piggyback Notice shall offer the Holder the opportunity to register under such Registration Statement, or to sell in such Public Offering, such number of Registrable Securities as each such Holder may request in
writing (a “Piggyback Registration”). Subject to Section 3.3.2, the Company shall include in such Registration Statement or in such Public Offering as applicable, all such Registrable Securities that are requested to be included
therein within five (5) 

  
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Business Days after the receipt by such Holder of any such notice; provided, however, that if at any time after giving written notice of its intention to register or sell any
securities and prior to the effective date of the Registration Statement filed in connection with such Registration, or the pricing or trade date of a Public Offering under a Shelf Registration Statement, the Company determines for any reason not to
register or sell or to delay the Registration or sale of such securities, the Company shall give written notice of such determination to each Holder and, thereupon, (i) in the case of a determination not to register or sell, shall be relieved
of its obligation to register or sell any Registrable Securities in connection with such Registration or Public Offering (but not from its obligation to pay the Registration Expenses in connection therewith), without prejudice, however, to the
rights of any Holder entitled to request that such Registration or sale be effected as a Demand Registration under Section 3.1 or an Underwritten Shelf Takedown under Section 3.2, as the case may be, and (ii) in the case of a determination to
delay Registration or sale, in the absence of a request for a Demand Registration or an Underwritten Shelf Takedown, as the case may be, shall be permitted to delay registering or selling any Registrable Securities, for the same period as the delay
in registering or selling such other securities. Any Holder shall have the right to withdraw all or part of its request for inclusion of its Registrable Securities in a Piggyback Registration by giving written notice to the Company of its
request to withdraw. 
 Section 3.3.2. Priority of Piggyback Registration. If the managing underwriter or
underwriters of any proposed offering of Registrable Securities included in a Piggyback Registration informs the Company and the participating Holders in writing that, in its or their opinion, the number of securities that such Holders and any other
Persons intend to include in such offering exceeds the number that can be sold in such offering without being likely to have a significant adverse effect on the price, timing or distribution of the securities offered or the market for the securities
offered, then the securities to be included in such Registration shall be (i) first, one hundred percent (100%) of the securities that the Company proposes to sell, and (ii) second, and only if all the securities referred to in clause (i)
have been included, the number of Registrable Securities requested to be sold by such Holder that, in the opinion of such managing underwriter or underwriters, can be sold without having such adverse effect, with such number to be allocated among
the Holders that have requested to participate in such Registration based on an amount equal to the lesser of (x) the number of such Registrable Securities requested to be sold by such Holder, and (y) a number of such shares equal to such
Holder’s Pro Rata Portion, and (iii) third, and only if all of the Registrable Securities referred to in clause (ii) have been included in such Registration, any other securities eligible for inclusion in such Registration. 

Section 3.3.3. No Effect on Other Registrations. No Registration of Registrable Securities effected pursuant to a
request under this Section 3.3 shall be deemed to have been effected pursuant to Sections 3.1 and 3.2 or shall relieve the Company of its obligations under Sections 3.1 and 3.2. 

Section 3.4. Lock-Up Agreements. In connection with each Registration or sale of Registrable Securities pursuant to
Section 3.1, 3.2 or 3.3 conducted as an Underwritten Public Offering, (i) the Company agrees, if requested, to cause its directors and officers and (ii) each Holder agrees, if requested, to 

  
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become bound by and to execute and deliver a lock-up agreement with the underwriter(s) of such Underwritten Public Offering restricting such director’s, officer’s and Holder’s
right to (a) Transfer, directly or indirectly, any equity securities of the Company held by such Holder, director or officer, as applicable or (b) enter into any swap or other arrangement that transfers to another any of the economic
consequences of ownership of such securities during the period commencing on the date of the final Prospectus relating to the Underwritten Public Offering and ending on the date specified by the underwriters (such period not to exceed ninety
(90) days in the case of any registration or sale, plus such additional period as may be requested by the Company or an underwriter to accommodate regulatory restrictions on the publication or other distribution of research reports and analyst
recommendations and opinions, if applicable); provided however, that in the case of any lock-up requested of a Holder that is not a director or officer, such lock-up shall only apply to direct sales of securities purchased by such Holder pursuant to
the Purchase Agreement (or securities issued or issuable upon the conversion or exercise of such securities), and shall not apply directly or indirectly to shares purchased by such Holder before or after the transaction contemplated by the Purchase
Agreement. The terms of such lock-up agreements shall be negotiated among Baupost, the Requisite Investors, the Company and the underwriters and shall include customary carve-outs from the restrictions on Transfer set forth therein. 

Section 3.5. Registration Procedures. 

Section 3.5.1. Requirements. In connection with the Company’s obligations under Sections 3.1 – 3.4 (and
in the case of 3.5.1(z) below, in connection with the Company’s obligations under Sections 3.1 – 3.4 and 3.10) the Company shall use its reasonable best efforts to effect such Registration and to permit the sale of such Registrable
Securities in accordance with the intended method or methods of distribution thereof as expeditiously as reasonably practicable, and in connection therewith the Company shall: 
  


	(a)	As promptly as practicable prepare the required Registration Statement, including all exhibits and financial statements required under the Securities Act to be filed therewith and Prospectus, and, before filing a
Registration Statement or Prospectus or any amendments or supplements thereto, (x) furnish to the underwriters, if any, and to the Holders of the Registrable Securities covered by such Registration Statement, copies of all documents prepared to
be filed, which documents shall be subject to the review of such underwriters and such Holders and their respective counsel, (y) make such changes in such documents concerning the Holders prior to the filing thereof as such Holders, or their
counsel, may reasonably request and (z) except in the case of a Registration under Section 3.3 not file any Registration Statement or Prospectus or amendments or supplements thereto to which the Holders, in such capacity, or the underwriters,
if any, shall reasonably object; 

  

	(b)	 prepare and timely file with the SEC such amendments and post-effective amendments to such Registration Statement and supplements to the Prospectus as
may be (x) reasonably requested by any Holder with Registrable Securities covered by such Registration Statement, (y) reasonably requested by any participating Holder (to the extent such request relates to information relating to such
Holder), or (z) necessary to keep such Registration Statement effective for the period of time required by this Agreement, and comply with provisions of the applicable securities laws with respect to the sale or other disposition of all
securities covered by such Registration Statement during such period in 



  
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accordance with the intended method or methods of disposition by the sellers thereof set forth in such Registration Statement; 


 

	(c)	notify the participating Holders and the managing underwriter or underwriters, if any, and (if requested) confirm such notice in writing and provide copies of the relevant documents, as soon as reasonably practicable
after notice thereof is received by the Company (v) when the applicable Registration Statement or any amendment thereto has been filed or becomes effective, and when the applicable Prospectus or any amendment or supplement thereto has been
filed, (w) of any written comments by the SEC, or any request by the SEC or other federal or state governmental authority for amendments or supplements to such Registration Statement or such Prospectus, or for additional information (whether
before or after the effective date of the Registration Statement) or any other correspondence with the SEC relating to, or which may affect, the Registration, (x) of the issuance by the SEC of any stop order suspending the effectiveness of such
Registration Statement or any order by the SEC or any other regulatory authority preventing or suspending the use of any preliminary or final Prospectus or the initiation or threatening of any proceedings for such purposes, (y) if, at any time,
the representations and warranties of the Company in any applicable underwriting agreement cease to be true and correct in all material respects and (z) of the receipt by the Company of any notification with respect to the suspension of the
qualification of the Registrable Securities for offering or sale in any jurisdiction or the initiation or threatening of any proceeding for such purpose; 

  

	(d)	promptly notify each selling Holder and the managing underwriter or underwriters, if any, when the Company becomes aware of the happening of any event as a result of which the applicable Registration Statement or the
Prospectus included in such Registration Statement (as then in effect) contains any untrue statement of a material fact or omits to state a material fact necessary to make the statements therein (in the case of such Prospectus or any preliminary
Prospectus, in light of the circumstances under which they were made) not misleading, when any Issuer Free Writing Prospectus includes information that may conflict with the information contained in the Registration Statement, or, if for any other
reason it shall be necessary during such time period to amend or supplement such Registration Statement or Prospectus in order to comply with the Securities Act and, as promptly as reasonably practicable thereafter, prepare and timely file with the
SEC, and furnish without charge to the selling Holders and the managing underwriter or underwriters, if any, an amendment or supplement to such Registration Statement or Prospectus, which shall correct such misstatement or omission or effect such
compliance; 

  

	(e)	to the extent the Company is eligible under the relevant provisions of Rule 430B under the Securities Act, if the Company files any Shelf Registration Statement, the Company shall include in such Shelf Registration
Statement such disclosures as may be required by Rule 430B under the Securities Act (referring to the unnamed selling security holders in a generic manner by identifying the initial offering of the securities to the Holders) in order to ensure that
the Holders may be added to such Shelf Registration Statement at a later time through the filing of a Prospectus supplement rather than a post-effective amendment; 


  
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	(f)	use its reasonable best efforts to prevent, or obtain the withdrawal of, any stop order or other order or notice preventing or suspending the use of any preliminary or final Prospectus; 


 

	(g)	promptly incorporate in a Prospectus supplement, Issuer Free Writing Prospectus or post-effective amendment such information as the managing underwriter or underwriters and Baupost or the Requisite Investors agree
should be included therein relating to the plan of distribution with respect to such Registrable Securities; and make all required filings of such Prospectus supplement, Issuer Free Writing Prospectus or post-effective amendment as soon as
reasonably practicable after being notified of the matters to be incorporated in such Prospectus supplement, Issuer Free Writing Prospectus or post-effective amendment; 


 

	(h)	furnish to each selling Holder and each underwriter, if any, without charge, as many conformed copies as such Holder or underwriter may reasonably request of the applicable Registration Statement and any amendment or
post-effective amendment or supplement thereto, including financial statements and schedules, all documents incorporated therein by reference and all exhibits (including those incorporated by reference); 


 

	(i)	deliver to each selling Holder and each underwriter, if any, without charge, as many copies of the applicable Prospectus (including each preliminary Prospectus) and any amendment or supplement thereto and such other
documents as such Holder or underwriter may reasonably request in order to facilitate the disposition of the Registrable Securities by such Holder or underwriter (it being understood that the Company shall consent to the use of such Prospectus or
any amendment or supplement thereto by each of the selling Holders and the underwriters, if any, in connection with the offering and sale of the Registrable Securities covered by such Prospectus or any amendment or supplement thereto);


  

	(j)	on or prior to the date on which the applicable Registration Statement becomes effective, use its reasonable best efforts to register or qualify, and cooperate with the selling Holders, the managing underwriter or
underwriters, if any, and their respective counsel, in connection with the Registration or qualification of such Registrable Securities for offer and sale under the securities or “Blue Sky” laws of each state and other jurisdiction as any
such selling Holder or managing underwriter or underwriters, if any, or their respective counsel reasonably request in writing and do any and all other acts or things reasonably necessary or advisable to keep such Registration or qualification in
effect for such period as required by Section 3.1 or Section 3.2, as applicable, provided that the Company shall not be required to qualify generally to do business in any jurisdiction where it is not then so qualified or to take any action
which would subject it to taxation or general service of process in any such jurisdiction where it is not then so subject; 

  

	(k)	cooperate with the selling Holders and the managing underwriter or underwriters, if any, to facilitate the timely preparation and delivery of certificates representing Registrable Securities to be sold and not bearing
any restrictive legends and enable such Registrable Securities to be in such denominations and registered in such names as the managing underwriters may request prior to any sale of Registrable Securities to the underwriters; 


  
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	(l)	use its reasonable best efforts to cause the Registrable Securities covered by the applicable Registration Statement to be registered with or approved by such other governmental agencies or authorities as may be
necessary to enable the seller or sellers thereof or the underwriter or underwriters, if any, to consummate the disposition of such Registrable Securities, including, if requested, to qualify the Indenture under the Trust Indenture Act of 1939;


  

	(m)	not later than the effective date of the applicable Registration Statement, provide a CUSIP number for applicable Registrable Securities and, as applicable, provide the Trustee under the Indenture with printed
certificates for the applicable Registrable Securities which are in a form eligible for deposit with The Depository Trust Company (in the case of a Registration Statement); 


 

	(n)	make such representations and warranties to the Holders being registered, and the underwriters or agents, if any, in form, substance and scope as are customarily made by issuers in public offerings similar to the
offering then being undertaken; 

  

	(o)	enter into such customary agreements (including underwriting and indemnification agreements) and take all such other actions as Baupost, the Requisite Investors or the managing underwriter or underwriters, if any,
reasonably request in order to expedite or facilitate the Registration and disposition of such Registrable Securities; 

  

	(p)	obtain for delivery to the Holders being registered and to the underwriter or underwriters, if any, an opinion or opinions from counsel for the Company dated the most recent effective date of the Registration Statement
or, in the event of an Underwritten Public Offering, the date of the closing under the underwriting agreement, in customary form, scope and substance, which opinions shall be reasonably satisfactory to such Holders or underwriters, as the case may
be, and their respective counsel; 

  

	(q)	in the case of an Underwritten Public Offering, obtain for delivery to the Company and the managing underwriter or underwriters, with copies to the Holders included in such Registration or sale, a comfort letter from
the Company’s independent certified public accountants or independent auditors (and, if necessary, any other independent certified public accountants or independent auditors of any subsidiary of the Company or any business acquired by the
Company for which financial statements and financial data are, or are required to be, included in the Registration Statement) in customary form and covering such matters of the type customarily covered by comfort letters as the managing underwriter
or underwriters reasonably request, dated the date of execution of the underwriting agreement and brought down to the closing under the underwriting agreement; 

  

	(r)	cooperate with each seller of Registrable Securities and each underwriter, if any, participating in the disposition of such Registrable Securities and their respective counsel in connection with any filings required to
be made with FINRA; 

  

	(s)	 use its reasonable best efforts to comply with all applicable securities laws and, if a Registration Statement was filed, make available to its
security holders, as soon as 



  
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reasonably practicable, an earnings statement satisfying the provisions of Section 11(a) of the Securities Act and the rules and regulations promulgated thereunder; 


 

	(t)	provide and cause to be maintained a transfer agent and registrar for all Registrable Securities covered by the applicable Registration Statement; 


 

	(u)	use its reasonable best efforts to cause all Registrable Securities covered by the applicable Registration Statement to be listed on each securities exchange on which any of the Company’s equity securities are then
listed or quoted and on each inter-dealer quotation system on which any of the Company’s equity securities are then quoted; 

  

	(v)	make available upon reasonable notice at reasonable times and for reasonable periods for inspection by a representative appointed by the Baupost, the Requisite Investors, by any underwriter participating in any
disposition to be effected pursuant to such Registration Statement and by any attorney, accountant or other agent retained by such Holders or any such underwriter, all pertinent financial and other records and pertinent corporate documents and
properties of the Company, and cause all of the Company’s officers, directors and employees and the independent public accountants who have certified its financial statements to make themselves available to discuss the business of the Company
and to supply all information reasonably requested by any such Person in connection with such Registration Statement; 

  

	(w)	in the case of an Underwritten Public Offering, cause the senior executive officers of the Company to participate in the customary “road show” presentations that may be reasonably requested by the managing
underwriter or underwriters in any such offering and otherwise to facilitate, cooperate with, and participate in each proposed offering contemplated herein and customary selling efforts related thereto; 


 

	(x)	take no direct or indirect action prohibited by Regulation M under the Exchange Act; 

  

	(y)	take all reasonable action to ensure that any Issuer Free Writing Prospectus utilized in connection with any Registration complies in all material respects with the Securities Act, is filed in accordance with the
Securities Act to the extent required thereby, is retained in accordance with the Securities Act to the extent required thereby and, when taken together with the related Prospectus, will not contain any untrue statement of a material fact or omit to
state a material fact necessary to make the statements therein, in light of the circumstances under which they were made, not misleading; 

  

	(z)	take all such other commercially reasonable actions as are necessary or advisable in order to expedite or facilitate the disposition of such Registrable Securities in accordance with the terms of this Agreement; and


  

	(aa)	take such other actions reasonably requested by Baupost or the Requisite Investors to conduct an offering of the Notes in accordance with Rule 144A, including any such actions (or substantially similar actions) that
would be permitted to be requested hereunder by Baupost or the Requisite Investors in connection with an Underwritten Public Offering if such Notes were Registrable Securities under this Agreement. 


  
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 Section 3.5.2. Company Information Requests. The Company may require
each seller of Registrable Securities as to which any Registration or sale is being effected to furnish to the Company such information regarding the distribution of such securities and such other information relating to such Holder and its
ownership of Registrable Securities as the Company may from time to time reasonably request in writing and the Company may exclude from such Registration or sale the Registrable Securities of any such Holder who unreasonably fails to furnish such
information within a reasonable time after receiving such request. Each Holder agrees to furnish such information to the Company and to cooperate with the Company as reasonably necessary to enable the Company to comply with the provisions of this
Agreement. 
 Section 3.5.3. Discontinuing Registration. Each Holder agrees that, upon receipt of any notice from the Company of the
happening of any event of the kind described in Section 3.5.1(d), such Holder will use its best efforts to discontinue disposition of Registrable Securities pursuant to such Registration Statement until such Holder’s receipt of the copies of
the supplemented or amended Prospectus contemplated by Section 3.5.1(d), or until such Holder is advised in writing by the Company that the use of the Prospectus may be resumed, and has received copies of any additional or supplemental filings that
are incorporated by reference in the Prospectus, or any amendments or supplements thereto, and if so directed by the Company, such Holder shall deliver to the Company (at the Company’s expense) all copies, other than permanent file copies then
in such Holder’s possession, of the Prospectus covering such Registrable Securities current at the time of receipt of such notice. In the event the Company shall give any such notice, the period during which the applicable Registration
Statement is required to be maintained effective shall be extended by the number of days during the period from and including the date of the giving of such notice to and including the date when each seller of Registrable Securities covered by such
Registration Statement either receives the copies of the supplemented or amended Prospectus contemplated by Section 3.5.1(d) or is advised in writing by the Company that the use of the Prospectus may be resumed. 

Section 3.6. Underwritten Offerings. 

Section 3.6.1. Shelf and Demand Registrations. If requested by the underwriters for any Underwritten Public Offering,
pursuant to a Registration or sale under Sections 3.1 or 3.2, the Company shall enter into an underwriting agreement with such underwriters, such agreement to be reasonably satisfactory in substance and form to each of the Company, Baupost and the
Requisite Investors participating in such offering and the underwriters, and to contain such representations and warranties by the Company and such other terms as are generally prevailing in agreements of that type, including indemnities no less
favorable to the recipient thereof than those provided in Section 3.9 of this Agreement. The Holders of the Registrable Securities proposed to be distributed by such underwriters shall cooperate with the Company in the negotiation of the
underwriting agreement and shall give consideration to the reasonable suggestions of the Company regarding the form thereof, and such Holders shall complete and execute all questionnaires, powers of attorney and other documents reasonably requested
by the underwriters and required under the terms of such underwriting arrangements. Any such Holder shall not be required to make any representations or warranties to or agreements with the Company or the underwriters other than
representations, warranties or agreements regarding such Holder, such Holder’s title to the Registrable Securities, such Holder’s intended method of 

  
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distribution and any other representations to be made by the Holder as are generally prevailing in agreements of that type, and the aggregate amount of the liability of such Holder under such
agreement shall not exceed such Holder’s proceeds from the sale of its Registrable Securities in the offering, net of underwriting discounts and commissions but before expenses. 

Section 3.6.2. Piggyback Registrations. If the Company proposes to register or sell any of its securities under the Securities Act
as contemplated by Section 3.3 and such securities are to be distributed through one or more underwriters, the Company shall, if requested by any Holder pursuant to Section 3.3 and, subject to the provisions of Section 3.3.2, use its reasonable best
efforts to arrange for such underwriters to include on the same terms and conditions that apply to the other sellers in such Registration or sale all the Registrable Securities to be offered and sold by such Holder among the securities of the
Company to be distributed by such underwriters in such Registration or sale. The Holders of Registrable Securities to be distributed by such underwriters shall be parties to the underwriting agreement between the Company and such underwriters
and shall complete and execute all questionnaires, powers of attorney and other documents reasonably requested by the underwriters and required under the terms of such underwriting arrangements. Any such Holder shall not be required to make any
representations or warranties to or agreements with the Company or the underwriters other than representations, warranties or agreements regarding such Holder, such Holder’s title to the Registrable Securities, such Holder’s intended
method of distribution and any other representations to be made by the Holder as are generally prevailing in agreements of that type, and the aggregate amount of the liability of such Holder shall not exceed such Holder’s proceeds from the sale
of its Registrable Securities in the offering, net of underwriting discounts and commissions but before expenses. 
 Section 3.6.3.
Selection of Underwriters; Selection of Counsel. In the case of an Underwritten Public Offering under Sections 3.1 or 3.2, the managing underwriter or underwriters to administer the offering shall be determined (x) if such
Underwritten Public Offering is made pursuant to a Demand Registration Request by Baupost pursuant to Section 3.1.1(a)(i) or a Shelf Takedown Request by Baupost pursuant to Section 3.2.4(a)(i), by Baupost, or (y) if such Underwritten Public Offering
is made pursuant to a Demand Registration Request by an Other Investor pursuant to Section 3.1.1(a)(ii) or a Shelf Takedown Request by an Other Investor pursuant to Section 3.2.4(a)(ii), by the Requisite Investors participating in the offering;
provided that such underwriter or underwriters shall be reasonably acceptable to the Company. In the case of an Underwritten Public Offering under Section 3.3, the managing underwriter or underwriters to administer the offering shall be
determined by the Company; provided that such underwriter or underwriters shall be reasonably acceptable to the Requisite Investors. In the case of an Underwritten Public Offering under Sections 3.1, 3.2 or 3.3, counsel to the Holders shall
be selected by the Requisite Investors. 
 Section 3.7. No Inconsistent Agreements; Additional Rights. Neither the Company nor any of
its subsidiaries shall hereafter enter into, and neither the Company nor any of its subsidiaries is currently a party to, any agreement with respect to its securities that is inconsistent with the rights granted to the Holders by this
Agreement. Neither the Company nor any of its subsidiaries shall enter into any agreement granting registration or similar rights to any Person, and the Company hereby represents and warrants that, as of the date hereof, no registration or
similar rights have been granted to any other Person other than pursuant to this Agreement. 

  
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 Section 3.8. Registration Expenses. All expenses incident to the Company’s
performance of or compliance with this Agreement shall be paid by the Company, including (i) all registration and filing fees, and any other fees and expenses associated with filings required to be made with the SEC or FINRA, (ii) all fees
and expenses in connection with compliance with any securities or “Blue Sky” laws (including reasonable fees and disbursements of counsel for the underwriters in connection with blue sky qualifications of the Registrable Securities),
(iii) all printing, duplicating, word processing, messenger, telephone, facsimile and delivery expenses (including expenses of printing certificates for the Registrable Securities in a form eligible for deposit with The Depository Trust Company
and of printing Prospectuses), (iv) all fees and disbursements of counsel for the Company and of all independent certified public accountants or independent auditors of the Company and any subsidiaries of the Company (including the expenses of
any special audit and comfort letters required by or incident to such performance), (v) Securities Act liability insurance or similar insurance if the Company so desires or the underwriters so require in accordance with then-customary
underwriting practice, (vi) all fees and expenses incurred in connection with the listing of the Registrable Securities on any securities exchange or quotation of the Registrable Securities on any inter-dealer quotation
system, (vii) all reasonable fees and disbursements of legal counsel for the selling Holders, (viii) any reasonable fees and disbursements of underwriters customarily paid by issuers or sellers of securities, (ix) all fees and
expenses incurred in connection with the distribution or Transfer of Registrable Securities to or by a Holder or its Permitted Transferees in connection with a Public Offering, (x) all fees and expenses of any special experts or other Persons
retained by the Company in connection with any Registration or sale, (xi) all of the Company’s internal expenses (including all salaries and expenses of its officers and employees performing legal or accounting duties) and (xii) all
expenses related to the “road show” for any Underwritten Public Offering, including the reasonable out-of-pocket expenses of the Holders and underwriters, if so requested. All such expenses are referred to herein as
“Registration Expenses”. The Company shall not be required to pay any fees and disbursements to underwriters not customarily paid by the issuers of securities in an offering similar to the applicable offering, including underwriting
discounts and commissions and transfer taxes, if any, attributable to the sale of Registrable Securities. 
 Section 3.9.
Indemnification.
 Section 3.9.1. Indemnification by the Company. The Company shall indemnify and hold harmless,
to the full extent permitted by law, each Holder, each stockholder, member, limited or general partner of such Holder, each stockholder, member, limited or general partner of each such stockholder, member, limited or general partner, each of their
respective Affiliates, officers, directors, stockholders, employees, advisors, and agents and each Person who controls, or is alleged to control, (within the meaning of the Securities Act or the Exchange Act) such Persons and each of their
respective Representatives from and against any and all losses, penalties, judgments, suits, costs, claims, damages, liabilities and expenses, joint or several (including reasonable costs of investigation and legal expenses and any indemnity and
contribution payments made to underwriters ) (each, a “Loss” and collectively “Losses”) arising out of or based upon (i) any untrue or alleged untrue statement of a material fact contained in any Registration
Statement under which such Registrable Securities are registered or sold under the Securities Act (including any final, preliminary or summary Prospectus contained therein or any amendment thereof or supplement thereto or any documents incorporated
by reference therein) 

  
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or any other disclosure document produced by or on behalf of the Company or any of its subsidiaries including, without limitation any report and other document filed under the Exchange Act and
any preliminary or final offering memorandum prepared in connection with any Rule 144A or Regulation S offering pursuant to Section 3.10 of this Agreement, (ii) any omission or alleged omission to state therein a material fact required to be stated
therein or necessary to make the statements therein (in the case of a Prospectus or preliminary Prospectus, in light of the circumstances under which they were made) not misleading or (iii) any violation or alleged violation by the Company or any of
its subsidiaries of any federal, state, foreign or common law rule or regulation applicable to the Company or any of its subsidiaries and relating to action or inaction in connection with any such registration, disclosure document or other document
or report; provided, that no selling Holder shall be entitled to indemnification pursuant to this Section 3.9.1 in respect of any untrue statement or omission contained in any information relating to such seller Holder furnished in writing by
such selling Holder to the Company specifically for inclusion in a Registration Statement and used by the Company in conformity therewith (such information “Selling Stockholder Information”). This indemnity shall be in addition to
any liability the Company may otherwise have. Such indemnity shall remain in full force and effect regardless of any investigation made by or on behalf of such Holder or any indemnified party and shall survive the Transfer of such securities by
such Holder and regardless of any indemnity agreed to in the underwriting agreement that is less favorable to the Holders. The Company shall also indemnify underwriters, initial purchasers, selling brokers, dealer managers and similar
securities industry professionals participating in the distribution, their officers and directors and each Person who controls such Persons (within the meaning of the Securities Act and the Exchange Act) to the same extent as provided above (with
appropriate modification) with respect to the indemnification of the indemnified parties. 
 Section 3.9.2. Indemnification by the
Selling Holders. Each selling Holder agrees (severally and not jointly) to indemnify and hold harmless, to the fullest extent permitted by law, the Company, its directors and officers and each Person who controls the Company (within the
meaning of the Securities Act or the Exchange Act) from and against any Losses resulting from (i) any untrue statement of a material fact in any Registration Statement under which such Registrable Securities were registered or sold under the
Securities Act (including any final, preliminary or summary Prospectus contained therein or any amendment thereof or supplement thereto or any documents incorporated by reference therein) or (ii) any omission to state therein a material fact
required to be stated therein or necessary to make the statements therein (in the case of a Prospectus or preliminary Prospectus, in light of the circumstances under which they were made) not misleading, in each case to the extent, but only to the
extent, that such untrue statement or omission is contained in such selling Holder’s Selling Stockholder Information. In no event shall the liability of any selling Holder hereunder be greater in amount than the dollar amount of the proceeds
from the sale of its Registrable Securities in the offering giving rise to such indemnification obligation, net of underwriting discounts and commissions but before expenses, less any amounts paid by such Holder pursuant to Section 3.9.4 and any
amounts paid by such Holder as a result of liabilities incurred under the underwriting agreement, if any, related to such sale.
 Section
3.9.3. Conduct of Indemnification Proceedings. Any Person entitled to indemnification hereunder shall (a) give prompt written notice to the indemnifying party of any claim with respect to which it seeks indemnification (provided
that any delay or failure to so 

  
 - 21 - 








 
notify the indemnifying party shall relieve the indemnifying party of its obligations hereunder only to the extent, if at all, that it forfeits substantive legal rights by reason of such delay or
failure) and (b) permit such indemnifying party to assume the defense of such claim with counsel reasonably satisfactory to the indemnified party; provided, however, that any Person entitled to indemnification hereunder shall have the
right to select and employ separate counsel and to participate in the defense of such claim, but the fees and expenses of such counsel shall be at the expense of such Person unless (i) the indemnifying party has agreed in writing to pay such fees or
expenses, (ii) the indemnifying party shall have failed to assume the defense of such claim within a reasonable time after receipt of notice of such claim from the Person entitled to indemnification hereunder and employ counsel reasonably
satisfactory to such Person, (iii) the indemnified party has reasonably concluded (based upon advice of its counsel) that there may be legal defenses available to it or other indemnified parties that are different from or in addition to those
available to the indemnifying party, or (iv) in the reasonable judgment of any such Person (based upon advice of its counsel) a conflict of interest may exist between such Person and the indemnifying party with respect to such claims (in which case,
if the Person notifies the indemnifying party in writing that such Person elects to employ separate counsel at the expense of the indemnifying party, the indemnifying party shall not have the right to assume the defense of such claim on behalf of
such Person). If the indemnifying party assumes the defense, the indemnifying party shall not have the right to settle such action without the consent of the indemnified party. No indemnifying party shall consent to entry of any judgment
or enter into any settlement which does not include as an unconditional term thereof the giving by the claimant or plaintiff to such indemnified party of an unconditional release from all liability in respect to such claim or litigation without the
prior written consent of such indemnified party. If such defense is not assumed by the indemnifying party, the indemnifying party will not be subject to any liability for any settlement made without its prior written consent, but such consent may
not be unreasonably withheld. It is understood that the indemnifying party or parties shall not, except as specifically set forth in this Section 3.9.3, in connection with any proceeding or related proceedings in the same jurisdiction, be
liable for the reasonable fees, disbursements or other charges of more than one separate firm admitted to practice in such jurisdiction at any one time unless (x) the employment of more than one counsel has been authorized in writing by the
indemnifying party or parties, (y) an indemnified party has reasonably concluded (based on the advice of counsel) that there may be legal defenses available to it that are different from or in addition to those available to the other indemnified
parties or (z) a conflict or potential conflict exists or may exist (based upon advice of counsel to an indemnified party) between such indemnified party and the other indemnified parties, in each of which cases the indemnifying party shall be
obligated to pay the reasonable fees and expenses of such additional counsel or counsels. 
 Section 3.9.4. Contribution. If for
any reason the indemnification provided for in Section 3.9.1 and Section 3.9.2 is unavailable to an indemnified party or insufficient in respect of any Losses referred to therein (other than as a result of exceptions or limitations on
indemnification contained in Section 3.9.1 and Section 3.9.2), then the indemnifying party shall contribute to the amount paid or payable by the indemnified party as a result of such Loss in such proportion as is appropriate to reflect the relative
fault of the indemnifying party on the one hand and the indemnified party or parties on the other hand in connection with the acts, statements or omissions that resulted in such Losses, as well as any other relevant equitable
considerations.

  
 - 22 - 








 
In connection with any Registration Statement filed with the SEC by the Company, the relative fault of the indemnifying party on the one hand and the indemnified party on the other hand shall be
determined by reference to, among other things, whether any untrue or alleged untrue statement of a material fact or the omission or alleged omission to state a material fact relates to information supplied by the indemnifying party or by the
indemnified party and the parties’ relative intent, knowledge, access to information and opportunity to correct or prevent such statement or omission. The parties hereto agree that it would not be just or equitable if contribution pursuant to
this Section 3.9.4 were determined by pro rata allocation or by any other method of allocation that does not take account of the equitable considerations referred to in this Section 3.9.4. No Person guilty of fraudulent
misrepresentation (within the meaning of Section 11(f) of the Securities Act) shall be entitled to contribution from any Person who was not guilty of such fraudulent misrepresentation. The amount paid or payable by an indemnified party as
a result of the Losses referred to in Sections 3.9.1 and 3.9.2 shall be deemed to include, subject to the limitations set forth above, any legal or other expenses reasonably incurred by such indemnified party in connection with investigating or
defending any such action or claim. Notwithstanding the provisions of this Section 3.9.4, in connection with any Registration Statement filed by the Company, a selling Holder shall not be required to contribute any amount in excess of the
dollar amount of the proceeds from the sale of its Registrable Securities in the offering giving rise to such indemnification obligation, net of underwriting discounts and commissions but before expenses, less any amounts paid by such Holder
pursuant to Section 3.9.2 and any amounts paid by such Holder as a result of liabilities incurred under the underwriting agreement, if any, related to such sale. If indemnification is available under this Section 3.9, the indemnifying parties
shall indemnify each indemnified party to the full extent provided in Sections 3.9.1 and 3.9.2 hereof without regard to the provisions of this Section 3.9.4. The remedies provided for in this Section 3.9 are not exclusive and shall not
limit any rights or remedies which may otherwise be available to any indemnified party at law or in equity. 
 Section 3.10. Rules 144
and 144A and Regulation S. The Company shall timely file the reports required to be filed by it under the Securities Act and the Exchange Act and the rules and regulations adopted by the SEC thereunder (or, if the Company is
not required to file such reports, it will, upon the request of the Holders, make publicly available such necessary information for so long as necessary to permit sales that would otherwise be permitted by this Agreement pursuant to Rule 144, Rule
144A or Regulation S under the Securities Act, as such rules may be amended from time to time or any similar rule or regulation hereafter adopted by the SEC), and it will take such further action as any Holder may reasonably request, all to the
extent required from time to time to enable such Holder to sell Registrable Securities without Registration under the Securities Act in transactions that would otherwise be permitted by this Agreement and within the limitation of the exemptions
provided by (i) Rule 144, Rule 144A or Regulation S under the Securities Act, as such rules may be amended from time to time, or (ii) any similar rule or regulation hereafter adopted by the SEC. Upon the request of any Holder, the Company will
deliver to such Holder a written statement as to whether it has complied with such requirements and, if not, the specifics thereof. 

Section 3.11. Existing Registration Statements. Notwithstanding anything herein to the contrary and subject to applicable law
and regulation, the Company may satisfy any obligation hereunder to file a Registration Statement or to have a Registration Statement become effective by a specified date by designating, by notice to the Holders, a Registration Statement that


  
 - 23 - 








 
previously has been filed with the SEC or become effective, as the case may be, as the relevant Registration Statement for purposes of satisfying such obligation, and all references to any such
obligation shall be construed accordingly; provided that such previously filed Registration Statement may be, and is, amended or, subject to applicable securities laws, supplemented to add the number of Registrable Securities, and, to the
extent necessary, to identify as a selling stockholders those Holders demanding the filing of a Registration Statement pursuant to the terms of this Agreement. To the extent this Agreement refers to the filing or effectiveness of other
Registration Statements, by or at a specified time and the Company has, in lieu of then filing such Registration Statements or having such Registration Statements become effective, designated a previously filed or effective Registration
Statement as the relevant Registration Statement for such purposes, in accordance with the preceding sentence, such references shall be construed to refer to such designated Registration Statement, as amended or supplemented in the manner
contemplated by the immediately preceding sentence. 
 ARTICLE IV 

GOVERNANCE 
 Section 4.1.
Composition of the Board of Directors. Upon written request of Baupost, the board of directors of the Company (the “Board”) shall appoint two individuals designated by Baupost (the “Baupost Designees”) to the
Board with a term expiring at the Company’s annual meeting of its stockholders (the “Annual Meeting”) occurring in 2018 and shall increase the size of the Board to accommodate such designees. 

For so long as Baupost or its Affiliates own twenty percent (20%) or more of the Company’s outstanding Common Stock (on an as-converted
and as-exercised basis, assuming Stockholder Approval has been obtained and without regard to the Trigger Date (as defined in the Indenture)), the Company shall nominate and recommend both Baupost Designees (or such successor or replacement
designated by Baupost) in the Company’s proxy statement at each Annual Meeting at which the Baupost Designees’ terms are set to expire. For so long as Baupost or its Affiliates own ten percent (10%) or more of the Company’s
outstanding Common Stock (on an as-converted and as-exercised basis, assuming Stockholder Approval has been obtained and without regard to the Trigger Date (as defined in the Indenture)), the Company shall nominate and recommend one Baupost Designee
(or such successor or replacement designated by Baupost) in the Company’s proxy statement at each Annual Meeting at which the Baupost Designee’s term is set to expire. The Company shall take all actions necessary to ensure there are
vacancies on the Board as of the effectiveness of this Agreement to permit the appointment of the Baupost Designees. In the event no Baupost Designee is designated with respect to any meeting, the person then in office as such designee shall be
presumed to be the applicable designee. The Company shall cause the Baupost Designees to be included in the slate of nominees presented by the Board to the stockholders of the Company for election as directors at the relevant annual meeting of the
stockholders and shall solicit proxies in favor of the election of such persons. The Company shall not solicit proxies of the stockholders of the Company to vote against any Baupost Designee or for the approval of any stockholder or other proposals
that are inconsistent with the rights afforded pursuant to this Section 4.1 and will take no action that is inconsistent with the objective of having the Baupost Designees serve on the Board. For so long as any Baupost Designee has the right to be
nominated pursuant to this Section 4.1, such 

  
 - 24 - 








 
designee shall have the right to serve on each committee of the Board, unless otherwise prohibited by law or applicable stock exchange rules. 

In the event of the death, resignation, or removal from office of a Baupost Designee for any reason, Baupost may appoint another person as the
Baupost Designee to fill the vacancy created thereby and the Company shall take all actions necessary to appoint such individual to the Board. 

If there is a vacancy on the Board as a result of a Baupost Designee’s failure to obtain the requisite approval of the Company’s
stockholders necessary for election at any annual or special meeting of the Company’s stockholders, and where no other individual is elected to fill such vacancy, Baupost shall have the right to designate another Baupost Designee to fill such
vacancy, and the Company shall take all actions necessary to appoint such individual to the Board. 
 During the period that a Baupost
Designee is a director of the Board, such director shall be entitled to the same benefits, including benefits under any director and officer indemnification or insurance policy maintained by the Company, as any other director of the Board. 

During the period between the effectiveness of this Agreement and the date Baupost or its Affiliates have ownership of less than ten percent
(10%) of the Company’s outstanding Common Stock (on an as-converted and as-exercised basis, assuming Stockholder Approval has been obtained and without regard to the Trigger Date (as defined in the Indenture)), Baupost shall have the right to
appoint one (1) non-voting board observer (the “Baupost Observer”) who shall (a) have the right to attend and participate in all meetings of the Board and committees of the Board and (b) be entitled to receive copies of all notices,
minutes, consents, and other materials that the Company provides to its directors at the same time and in the same manner as provided to such directors, provided, that a majority of the members of the Board shall be entitled to exclude the
Baupost Observer from portions of any meeting of the Board or committee thereof and to redact portions of any materials delivered to such Baupost Observer when and to the extent that such majority determines in good faith that (i) such exclusion or
redaction is reasonably necessary to preserve attorney-client privilege with respect to a matter that is material to the business of the Company or (ii) there exists, with respect to any deliberation or materials, a conflict of interest between such
Baupost Observer and the Company. 
 ARTICLE V 

MISCELLANEOUS 
 Section
5.1. Authority; Effect. Each party hereto represents and warrants to and agrees with each other party that the execution and delivery of this Agreement and the consummation of the transactions contemplated hereby have been
duly authorized on behalf of such party and do not violate any agreement or other instrument applicable to such party or by which its assets are bound. This Agreement does not, and shall not be construed to, give rise to the creation of a
partnership among any of the parties hereto, or to constitute any of such parties members of a joint venture or other association. The Company and its subsidiaries shall be jointly and severally liable for all obligations of each such party
pursuant to this 

  
 - 25 - 








 
Agreement. 
 Section 5.2. Notices. Any notices, requests, demands and other
communications required or permitted in this Agreement shall be effective if in writing and (i) delivered personally, (ii) sent by facsimile or e-mail, or (iii) sent by overnight courier, in each case, addressed as follows: 

If to the Company to: 
 Orexigen
Therapeutics, Inc. 
 3344 N. Torrey Pines Court 

Suite 200 
 La Jolla, CA 92037


					
		 	Attention:	 	Michael Narachi, Chief Executive Officer
		 	Facsimile:	 	(858) 875-8650
		 	E-mail:	 	mnarachi@orexigen.com

 with a copy (which shall not constitute notice) to: 

Cooley LLP 
 101 California Street

 5th floor 

San Francisco, CA 94111 

Attention: David Peinsipp, Esq. 

E-mail: dpeinsipp@cooley.com 
 If to
Baupost, to: 
  

			
	 Baupost Group Securities, L.L.C.

c/o The Baupost Group, L.L.C.
 10 St. James Avenue, Suite 1700

Boston, MA 02116

	 Attention:
	 	Gregory A. Ciongoli, Patrick McKee, Frederick H. Fogel, and John F. Harvey
	 Facsimile:
	 	(617) 451-7331
	 E-mail:
	 	gac@baupost.com, pmm@baupost.com, ffogel@baupost.com, and jharvey@baupost.com

 with a copy (which shall not constitute notice) to: 
  

			
	 Ropes & Gray LLP
 Three
Embarcadero Center
 San Francisco, CA 94111

	 Attention:
	 	Thomas Holden
	 Facsimile:
	 	(415) 315-4823
	 E-mail:
	 	thomas.holden@ropesgray.com


  
 - 26 - 








 If to an Other Investor, then to such address as set forth opposite such Other Investor’s name on Schedule
A. 
 Notice to the holder of record of any Registrable Securities shall be deemed to be notice to the holder of such securities for all
purposes hereof. 
 Unless otherwise specified herein, such notices or other communications shall be deemed effective (i) on the date
received, if personally delivered, (ii) on the date received if delivered by facsimile or e-mail on a Business Day, or if not delivered on a Business Day, on the first Business Day thereafter and (iii) two (2) Business Days after being sent by
overnight courier. Each of the parties hereto shall be entitled to specify a different address by giving notice as aforesaid to each of the other parties hereto. 

Section 5.3. Termination and Effect of Termination. This Agreement shall terminate upon the date on which no Holder holds any
Registrable Securities, except for the provisions of Sections 3.9 and 3.10, which shall survive any such termination. No termination under this Agreement shall relieve any Person of liability for breach or Registration Expenses incurred
prior to termination. In the event this Agreement is terminated, each Person entitled to indemnification rights pursuant to Section 3.9 hereof shall retain such indemnification rights with respect to any matter that (i) may be an indemnified
liability thereunder and (ii) occurred prior to such termination. 
 Section 5.4. Permitted Transferees. The rights of a Holder
hereunder may be assigned (but only with all related obligations as set forth below) in connection with a Transfer of Registrable Securities to a Permitted Transferee of that Holder. Without prejudice to any other or similar conditions imposed
hereunder with respect to any such Transfer, no assignment permitted under the terms of this Section 5.4 will be effective unless the Permitted Transferee to which the assignment is being made, if not a Holder, has delivered to the Company a written
acknowledgment and agreement in form and substance reasonably satisfactory to the Company that the Permitted Transferee will be bound by, and will be a party to, this Agreement. A Permitted Transferee to whom rights are transferred pursuant to
this Section 5.4 may not again transfer those rights to any other Permitted Transferee, other than as provided in this Section 5.4. 

Section 5.5. Remedies. The parties to this Agreement shall have all remedies available at law, in equity or otherwise in the
event of any breach or violation of this Agreement or any default hereunder. The parties acknowledge and agree that in the event of any breach of this Agreement, in addition to any other remedies that may be available, each of the parties
hereto shall be entitled to specific performance of the obligations of the other parties hereto and, in addition, to such other equitable remedies (including preliminary or temporary relief) as may be appropriate in the circumstances. No delay
of or omission in the exercise of any right, power or remedy accruing to any party as a result of any breach or default by any other party under this Agreement shall impair any such right, power or remedy, nor shall it be construed as a waiver of or
acquiescence in any such breach or default, or of any similar breach or default occurring later; nor shall any such delay, omission nor waiver of any single breach or default be deemed a waiver of any other breach or default occurring before or
after that waiver. 
 Section 5.6. Amendments. This Agreement may not be orally amended, modified,


  
 - 27 - 








 
extended or terminated, nor shall any oral waiver of any of its terms be effective. This Agreement may be amended, modified, extended or terminated, and the provisions hereof may be waived,
only by an agreement in writing signed by the Company and holders of at least 70% of the shares of Common Stock held by the Investors or their Affiliates (on an as-converted and as-exercised basis, assuming Stockholder Approval has been obtained and
without regard to the Trigger Date (as defined in the Indenture)). Each such amendment, modification, extension or termination shall be binding upon each party hereto. Notwithstanding the foregoing, no waiver, amendment, modification, extension or
termination of any rights granted to Baupost under this Agreement shall be valid or effective without the prior written consent of Baupost. In addition, each party hereto may waive any right hereunder by an instrument in writing signed by such
party. 
 Section 5.7. Governing Law. This Agreement and all claims arising out of or based upon this Agreement or relating to the
subject matter hereof shall be governed by and construed in accordance with the domestic substantive laws of the State of New York without giving effect to any choice or conflict of laws provision or rule that would cause the application of the
domestic substantive laws of any other jurisdiction. 
 Section 5.8. Consent to Jurisdiction. Each party to this Agreement, by its
execution hereof, (i) hereby irrevocably submits to the exclusive jurisdiction of the state and federal courts sitting in the State of New York for the purpose of any action, claim, cause of action or suit (in contract, tort or otherwise), inquiry,
proceeding or investigation arising out of or based upon this Agreement or relating to the subject matter hereof, (ii) hereby waives to the extent not prohibited by applicable law, and agrees not to assert, and agrees not to allow any of its
subsidiaries to assert, by way of motion, as a defense or otherwise, in any such action, any claim that it is not subject personally to the jurisdiction of the above-named courts, that its property is exempt or immune from attachment or execution,
that any such proceeding brought in one of the above-named courts is improper, or that this Agreement or the subject matter hereof or thereof may not be enforced in or by such court and (iii) hereby agrees not to commence or maintain any action,
claim, cause of action or suit (in contract, tort or otherwise), inquiry, proceeding or investigation arising out of or based upon this Agreement or relating to the subject matter hereof or thereof other than before one of the above-named courts nor
to make any motion or take any other action seeking or intending to cause the transfer or removal of any such action, claim, cause of action or suit (in contract, tort or otherwise), inquiry, proceeding or investigation to any court other than one
of the above-named courts whether on the grounds of inconvenient forum or otherwise. Notwithstanding the foregoing, to the extent that any party hereto is or becomes a party in any litigation in connection with which it may assert
indemnification rights set forth in this Agreement, the court in which such litigation is being heard shall be deemed to be included in clause (i) above. Notwithstanding the foregoing, any party to this Agreement may commence and maintain an
action to enforce a judgment of any of the above-named courts in any court of competent jurisdiction. Each party hereto hereby consents to service of process in any such proceeding in any manner permitted by New York law, and agrees that
service of process by registered or certified mail, return receipt requested, at its address specified pursuant to Section 5.2 hereof is reasonably calculated to give actual notice. 

Section 5.9. WAIVER OF JURY TRIAL. TO THE EXTENT NOT PROHIBITED BY APPLICABLE LAW WHICH CANNOT BE WAIVED, EACH PARTY HERETO


  
 - 28 - 








 
HEREBY WAIVES AND COVENANTS THAT IT WILL NOT ASSERT (WHETHER AS PLAINTIFF, DEFENDANT OR OTHERWISE) ANY RIGHT TO TRIAL BY JURY IN ANY FORUM IN RESPECT OF ANY ISSUE OR ACTION, CLAIM, CAUSE OF
ACTION OR SUIT (IN CONTRACT, TORT OR OTHERWISE), INQUIRY, PROCEEDING OR INVESTIGATION ARISING OUT OF OR BASED UPON THIS AGREEMENT OR THE SUBJECT MATTER HEREOF OR IN ANY WAY CONNECTED WITH OR RELATED OR INCIDENTAL TO THE TRANSACTIONS CONTEMPLATED
HEREBY, IN EACH CASE WHETHER NOW EXISTING OR HEREAFTER ARISING. EACH PARTY HERETO ACKNOWLEDGES THAT IT HAS BEEN INFORMED BY THE OTHER PARTIES HERETO THAT THIS SECTION 5.9 CONSTITUTES A MATERIAL INDUCEMENT UPON WHICH THEY ARE RELYING AND WILL
RELY IN ENTERING INTO THIS AGREEMENT. ANY PARTY HERETO MAY FILE AN ORIGINAL COUNTERPART OR A COPY OF THIS SECTION 5.9 WITH ANY COURT AS WRITTEN EVIDENCE OF THE CONSENT OF EACH SUCH PARTY TO THE WAIVER OF ITS RIGHT TO TRIAL BY JURY. 

Section 5.10. Merger; Binding Effect, Etc. This Agreement constitutes the entire agreement of the parties with respect to its subject
matter, supersedes all prior or contemporaneous oral or written agreements or discussions with respect to such subject matter, and shall be binding upon and inure to the benefit of the parties hereto and thereto and their respective heirs,
representatives, successors and permitted assigns. Except as otherwise expressly provided herein, no Holder or other party hereto may assign any of its respective rights or delegate any of its respective obligations under this Agreement without
the prior written consent of the other parties hereto, and any attempted assignment or delegation in violation of the foregoing shall be null and void. 

Section 5.11. Counterparts. This Agreement may be executed in multiple counterparts, each of which shall be deemed an original, but all
of which taken together shall constitute one instrument. 
 Section 5.12. Severability. In the event that any provision hereof would,
under applicable law, be invalid or unenforceable in any respect, such provision shall be construed by modifying or limiting it so as to be valid and enforceable to the maximum extent compatible with, and possible under, applicable law. The
provisions hereof are severable, and in the event any provision hereof should be held invalid or unenforceable in any respect, it shall not invalidate, render unenforceable or otherwise affect any other provision hereof. 

Section 5.13. No Recourse. Notwithstanding anything that may be expressed or implied in this Agreement, the Company and each Holder
covenant, agree and acknowledge that no recourse under this Agreement or any documents or instruments delivered in connection with this Agreement shall be had against any current or future director, officer, employee, general or limited partner or
member of any Holder or of any Affiliate or assignee thereof, as such, whether by the enforcement of any assessment or by any legal or equitable proceeding, or by virtue of any statute, regulation or other applicable law, it being expressly agreed
and acknowledged that no personal liability whatsoever shall attach to, be imposed on or otherwise be incurred by any current or future officer, agent or employee of any Holder or any current or future member of any Holder or any current or future
director, officer, employee, partner or member of any Holder or of any Affiliate or assignee thereof, as such, for any obligation of any Holder under this 

  
 - 29 - 








 
Agreement or any documents or instruments delivered in connection with this Agreement for any claim based on, in respect of or by reason of such obligations or their creation. 

[Signature pages follow] 

  
 - 30 - 








 IN WITNESS WHEREOF, each of the undersigned has duly executed this Agreement as of the
date first above written. 
  

							
	 Company:
	 		 	OREXIGEN THERAPEUTICS, INC.
				
		 		 	By:	 	 /s/ Michael A. Narachi

		 		 		 	Name: Michael A. Narachi
		 		 		 	Title: President and Chief Executive Officer
			
	 Baupost:
	 		 	BAUPOST GROUP SECURITIES, L.L.C.
				
		 		 	By:	 	 /s/ Gregory Ciongoli

		 		 		 	Name: Gregory Ciongoli
		 		 		 	Title: Partner
			
	 Other Investors:
	 		 	ROCK SPRINGS CAPITAL MASTER FUND LP
				
		 		 	By:	 	 /s/ Graham McPhail

		 		 		 	Name: Graham McPhail
		 		 		 	Title: Managing Director/Member of the GP
			
		 		 	TELEMETRY SECURITIES LLC
				
		 		 	By:	 	 /s/ Dan Sommers

		 		 		 	Name: Dan Sommers
		 		 		 	Title: Portfolio Manager
			
		 		 	EcoR1 CAPITAL FUND, L.P.
				
		 		 	By:	 	 /s/ Oleg Nodelman

		 		 		 	Name: Oleg Nodelman
		 		 		 	Title: Managing Director
			
		 		 	EcoR1 CAPITAL FUND QUALIFIED, L.P.
				
		 		 	By:	 	 /s/ Oleg Nodelman

		 		 		 	Name: Oleg Nodelman
		 		 		 	Title: Managing Director
			
		 		 	683 CAPITAL PARTNERS LP
				
		 		 	By:	 	 /s/ Joseph Patt

		 		 		 	Name: Joseph Patt
		 		 		 	Title: Partner – Head Trader


  
 [Signature Page to
Investor Rights Agreement] 









							
			
		 		 	CC ARBITRAGE, LTD.
				
		 		 	By:	 	 /s/ Peter C. Fletcher

		 		 		 	Name: Peter C. Fletcher
		 		 		 	Title: Portfolio Manager
			
		 		 	CC ARB SIF I, LTD.
				
		 		 	By:	 	 /s/ Peter C. Fletcher

		 		 		 	Name: Peter C. Fletcher
		 		 		 	Title: Portfolio Manager
			
		 		 	CC ARB WEST, LLC
				
		 		 	By:	 	 /s/ Peter C. Fletcher

		 		 		 	Name: Peter C. Fletcher
		 		 		 	Title: Portfolio Manager
			
		 		 	 HIGHBRIDGE INTERNATIONAL LLC
 By:
Highbridge Capital Management, LLC,
 as Trading Manager

				
		 		 	By:	 	 /s/ Jason Hempel

		 		 		 	Name: Jason Hempel
		 		 		 	Title: Managing Director
			
		 		 	 HIGHBRIDGE TACTICAL CREDIT &

CONVERTIBLES MASTER FUND, L.P.
 By: Highbridge Capital Management,
LLC,
 as Trading Manager

				
		 		 	By:	 	 /s/ Jason Hempel

		 		 		 	Name: Jason Hempel
		 		 		 	Title: Managing Director
			
		 		 	 O’CONNOR GLOBAL MULTI-STRATEGY

ALPHA MASTER LIMITED

				
		 		 	By:	 	 /s/ Andrew Martin

		 		 		 	Name: Andrew Martin
		 		 		 	Title: Managing Director
			
		 		 	 NINETEEN77 GLOBAL MULTI-STRATEGY

ALPHA (LEVERED) MASTER LIMITED

				
		 		 	By:	 	 /s/ Andrew Martin

		 		 		 	Name: Andrew Martin
		 		 		 	Title: Managing Director


  
 [Signature Page to
Investor Rights Agreement] 









							
			
		 		 	BIOTECHNOLOGY VALUE FUND, L.P.
				
		 		 	By:	 	 /s/ Mark Lampert

		 		 		 	 Mark Lampert
 President of BVF Inc.

General Partner of BVF Partners, L.P.
 General Partner of
Biotechnology Value Fund, L.P.

			
		 		 	BIOTECHNOLOGY VALUE FUND II, L.P.
				
		 		 	By:	 	 /s/ Mark Lampert

		 		 		 	 Mark Lampert
 President of BVF Inc.

General Partner of BVF Partners, L.P.
 General Partner of
Biotechnology Value Fund II, L.P.

			
		 		 	 BIOTECHNOLOGY VALUE TRADING
 FUND
OS, L.P.

				
		 		 	By:	 	 /s/ Mark Lampert

		 		 		 	 Mark Lampert
 President of BVF Inc.

General Partner of BVF Partners, L.P.
 Sole Member of BVF Partners
OS, Ltd.
 General Partner of Biotechnology Value Trading
 Fund
OS, L.P.

			
		 		 	INVESTMENT 10, LLC
				
		 		 	By:	 	 /s/ Mark Lampert

		 		 		 	 Mark Lampert
 President of BVF Inc.

General Partner of BVF Partners, L.P.
 Attorney-in-fact for
Investment 10, LLC

			
		 		 	MSI BVF SPV, LLC
				
		 		 	By:	 	 /s/ Mark Lampert

		 		 		 	 Mark Lampert
 President of BVF Inc.

General Partner of BVF Partners, L.P.
 Attorney-in-fact for MSI
BVF SPV, LLC

			
		 		 	ROADRUNNER CO.
				
		 		 	By:	 	 /s/ Mark Lampert

		 		 		 	 Mark Lampert
 President of BVF Inc.

General Partner of BVF Partners, L.P.
 Attorney-in-fact for
Roadrunner Co.



  
 [Signature Page to
Investor Rights Agreement] 









							
			
		 		 	SABBY HEALTHCARE MASTER FUND, LTD.
				
		 		 	By:	 	 /s/ Robert Grundstein

		 		 		 	Name: Robert Grundstein
		 		 		 	Title: COO of Investment Manager
			
		 		 	 SABBY VOLATILITY WARRANT MASTER FUND, LTD.

				
		 		 	By:	 	 /s/ Robert Grundstein

		 		 		 	Name: Robert Grundstein
		 		 		 	Title: COO of Investment Manager

  

  
 [Signature Page to
Investor Rights Agreement] 








 SCHEDULE A 

SCHEDULE OF OTHER INVESTORS 
  

					
	 	  	 Purchaser
	  	 
			
		  	 Baupost Group Securities, L.L.C.
 c/o
State Street Bank and Trust
 200 Newport Avenue, 6th Floor

North Quincy, MA 02171
 Attention: Mike Manganaro
	  	
			
		  	 Rock Springs Capital Master Fund LP
 c/o
Rock Springs Capital
 650 South Exeter Street, Suite 1070

Baltimore, MD 21202
 Attention: Graham McPhail
	  	
			
		  	 Telemetry Securities LLC
 545 Fifth
Avenue, Suite 1108
 New York, NY 10017
 Attention: Dan
Sommers
	  	
			
		  	 EcoR1 Capital Fund, L.P
 409 Illinois
Street
 San Francisco, CA 94158
 Attention: Oleg
Nodelman
	  	
			
		  	 EcoR1 Capital Fund Qualified, L.P.
 409
Illinois Street
 San Francisco, CA 94158
 Attention: Oleg
Nodelman
	  	
			
		  	 683 Capital Partners LP
 3 Columbus
Circle, Suite 2205
 New York, NY 10019
 Attention: Joseph
Patt
	  	
			
		  	 CC Arbitrage, Ltd.
 c/o Castle Creek
Capital
 227 West Monroe, Suite 2550
 Chicago, IL 60606

Attention: Peter Fletcher
	  	
			
		  	 CC ARB SIF I, Ltd.
 c/o Castle Creek
Capital
 227 West Monroe, Suite 2550
 Chicago, IL 60606

Attention: Peter Fletcher
	  	









					
			
		  	 CC ARB West, LLC
 c/o Castle Creek
Capital
 227 West Monroe, Suite 2550
 Chicago, IL 60606

Attention: Peter Fletcher
	  	
			
		  	 Highbridge International LLC
 c/o
Highbridge Capital Management, LLC
 40 W. 57th Street, Floor 32

New York, NY 10019
 Attention: Jason Hempel
	  	
			
		  	 Highbridge Tactical Credit & Convertibles Master Fund, L.P.

c/o Highbridge Capital Management, LLC
 40 W. 57th Street, Floor 32
 New York, NY 10019

Attention: Jason Hempel
	  	
			
		  	 O’Connor Global Multi-Strategy Alpha Master Limited

c/o UBS O’Connor LLC
 1 North Wacker Drive, 32nd Floor

Chicago, IL 60606
	  	
			
		  	 Nineteen77 Global Multi-Strategy Alpha (Levered) Master Limited 

c/o UBS O’Connor LLC
 1 North Wacker Drive, 32nd Floor

Chicago, IL 60606
	  	
			
		  	 Biotechnology Value Fund, L.P.
 c/o BVF
Partners
 One Sansome Street, 30th Floor

San Francisco, CA 94104
 Attention: Mark Lampert
	  	
			
		  	 Biotechnology Value Fund II, L.P.
 c/o
BVF Partners
 One Sansome Street, 30th Floor

San Francisco, CA 94104
 Attention: Mark Lampert
	  	
			
		  	 Biotechnology Value Trading Fund OS, L.P.

c/o BVF Partners
 One Sansome Street, 30th Floor
 San Francisco, CA 94104

Attention: Mark Lampert
	  	
			
		  	 Investment 10, LLC
 c/o BVF Partners

One Sansome Street, 30th Floor

San Francisco, CA 94104
 Attention: Mark Lampert
	  	
			
		  	 MSI BVF SPV, LLC
 c/o BVF Partners

One Sansome Street, 30th Floor

San Francisco, CA 94104
 Attention: Mark Lampert
	  	









					
			
		  	 Roadrunner Co.
 c/o BVF Partners

One Sansome Street, 30th Floor

San Francisco, CA 94104
 Attention: Mark Lampert
	  	
			
		  	 Sabby Healthcare Master Fund, Ltd.
 c/o
Sabby Management
 10 Mountainview Road
 Upper Saddle River, NJ
07458
 Attention: Robert Grundstein
	  	
			
		  	 Sabby Volatility Warrant Master Fund, Ltd.

c/o Sabby Management
 10 Mountainview Road

Upper Saddle River, NJ 07458
 Attention: Robert
Grundstein