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**SECURITIES        AND EXCHANGE COMMISSION**

**WASHINGTON,        D.C. 20549**

**FORM        S-8**

**REGISTRATION        STATEMENT UNDER**

**THE        SECURITIES ACT OF 1933**

**PROGENICS        PHARMACEUTICALS, INC.**

**(Exact        name of registrant as specified in its charter)**

| **DELAWARE****(State                  or other jurisdiction of incorporation or                  organization)** | **777                  Old Saw Mill River Road****Tarrytown,                  New York 10591****(Address                  of Principal Executive Offices) (Zip Code)** | **13-3379479****(I.R.S.                  Employer****Identification                  No.)** |
|------------------------------------------------------------------------------------------------------------------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------|---------------------------------------------------------------------------------------------|

**Amended        2005 Stock Incentive Plan**

**(Full        Title of the Plan)**

**Paul        J. Maddon, M.D., Ph.D.**

**Chief        Executive Officer and Chief Science Officer**

**Progenics        Pharmaceuticals, Inc.**

**777        Saw Mill River Road**

**Tarrytown,        New York 10591**

**Telephone        number, including area code, of agent for service: **

**(914)        789-2800**

**CALCULATION        OF REGISTRATION FEE**

| **Title                    of Each Class of****Securities****To                    Be Registered** | **Amount****To                    Be Registered(1)** | **Proposed                    Maximum****Offering                    Price****Per                    Share(2)** | **Proposed                    Maximum****Aggregate                    Offering****Price(2)** | **Amount                    of****Registration                    Fee** |
|----------------------------------------------------------------------------------------------------|------------------------------------------------------|-----------------------------------------------------------------------------------------------------------------|----------------------------------------------------------------------------------------------|-------------------------------------------------------------------------|
| Common                    Stock, $0.0013 par value per share                                       | 1,950,000                                            | $22.06                                                                                                          | $43,017,000                                                                                  | $1,320.62                                                               |

| (1) | Plus                  such additional shares as may be issued by reason of stock splits,                  stock                  dividends or similar transactions.                                                                                                                                                                                                                                                 |
|-----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| (2) | Pursuant                  to Rules 457(h) and 457(c), these prices are estimated solely for                  the                  purpose of calculating the registration fee and are based upon                  the average                  of the high and low sales prices of the Registrant's common stock                  on the                  Nasdaq National Market on June 8, 2007                  . |

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**EXPLANATORY        STATEMENT**

**PART        I **

**INFORMATION        REQUIRED IN THE SECTION 10(a) PROSPECTUS **

**PART        II**

**INFORMATION        REQUIRED IN THE REGISTRATION STATEMENT**

**Item        3. Incorporation of Documents by Reference.**

|   | a) | The                  Registrant's Annual Report on Form 10-K for the fiscal year ended                  December                  31, 2006 filed with the SEC on March 15,                  2007; |
|--------|----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|          b) |     The                    Registrant’s Quarterly Report on Form 10-Q for the quarter ended March 31,                    2007 filed with the SEC on May 9, 2007; |
|----------------------------------------------------------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|           | c)                       The Registrant’s Current Report on Form 8-K filed on January 8, 2007;                    and |
|--------------------------------------------------------|--------------------------------------------------------------------------------------------------------------------------------------------|

|   |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           |
|--------|--------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|   | d)     | The                  description of the Company's Common Stock in the Registrant's registration                  statement on Form 8-A dated September 29, 1997, File No. 0-23143                  pursuant                  to Section 12 of the Securities Exchange Act of 1934, as amended                  (the                  “Exchange Act”) including all amendments or reports filed with the                  Commission for the purpose of updating such                  description. |

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**Item        4. Description of Securities.**

**Item        5. Interests of Named Experts and Counsel.**

**Item        6. Indemnification of Directors and Officers.**

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**Item        7. Exemption from Registration Claimed.**

**Item        8. Exhibits.**

| **Exhibit****Number** |   |   | **Description**                                                                                                                                                                                                                                                       |   |   |                            |   |
|-----------------------|--------|--------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|--------|---------------------------------|--------|
|                  |   |   |                                                                                                                                                                                                                                                                  |   |   |                            |   |
| 5.1                   |   |   | Opinion                  and Consent of Mark R. Baker, Senior Vice President and General                  Counsel,                  Progenics Pharmaceuticals, Inc. with respect to the legality of                  the                  securities being registered |   |   | Filed                  herewith |   |
|                  |   |   |                                                                                                                                                                                                                                                                  |   |   |                            |   |
| 10.1                  |   |   | Amended                  2005 Stock Incentive Plan                                                                                                                                                                                                                    |   |   | Filed                  herewith |   |
|                  |   |   |                                                                                                                                                                                                                                                                  |   |   |                            |   |
| 23.1                  |   |   | Consent                  of Mark R. Baker, Senior Vice President and General Counsel of                  Progenics                  Pharmaceuticals, Inc. (contained in his opinion filed herewith as                  Exhibit 5.1)                              |   |   | Filed                  herewith |   |
|                  |   |   |                                                                                                                                                                                                                                                                  |   |   |                            |   |
| 23.2                  |   |   | Consent                  of PricewaterhouseCoopers LLP                                                                                                                                                                                                                |   |   | Filed                  herewith |   |
|                  |   |   |                                                                                                                                                                                                                                                                  |   |   |                            |   |
| 24.1                  |   |   | Power                  of Attorney of directors and certain officers of the Company (included                  in                  Signature Page)                                                                                                                    |   |   | Filed                  herewith |   |

**Item        9. Undertakings.**

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(2)        That,        for the purpose of determining any liability under the Securities Act of        1933,        each such post-effective amendment shall be deemed to be a new registration        statement relating to the securities offered therein, and the offering of        such        securities at that time shall be deemed to be the initial bona fide offering        thereof.

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**SIGNATURES**

*The        Registrant*

|   |   | PROGENICS                  PHARMACEUTICALS, INC. |
|--------|--------|--------------------------------------------------|

|   |   |                                                                                |
|--------|--------|-------------------------------------------------------------------------------------|
|   | By:    | /s/                  PAUL J. MADDON, M.D., PH.D.                                    |
|   |   | Paul                  J. Maddon, M.D., Ph.D.                                        |
|   |   | Chief                  Executive Officer and Chief Science                  Officer |

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**POWER        OF ATTORNEY**

| **Signature**                                                                                          | **Capacity**                                                                                                                                                          |   | **Date**                       |
|--------------------------------------------------------------------------------------------------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|--------------------------------|
|                                                                                                   |                                                                                                                                                                  |   |                           |
| /s/                  KURT W. BRINERKurt                  W. Briner                                     | Co-Chairman                  of the Board                                                                                                                             |   | June                  12, 2007 |
|                                                                                                   |                                                                                                                                                                  |   |                           |
| /s/                  PAUL F. JACOBSONPaul                  F. Jacobson                                 | Co-Chairman                  of the Board                                                                                                                             |   | June                  12, 2007 |
|                                                                                                   |                                                                                                                                                                  |   |                           |
| /s/                  PAUL J. MADDON, M.D., PH.D.Paul                  J. Maddon, M.D., Ph.D.           | Chief                  Executive Officer and Chief Science Officer (Principal Executive                  Officer)                                                     |   | June                  12, 2007 |
|                                                                                                   |                                                                                                                                                                  |   |                           |
| /s/                  ROBERT A. MCKINNEYRobert                  A. McKinney                             | Chief                  Financial Officer, Senior Vice President, Finance & Operations and                  Treasurer (Principal Financial and Accounting Officer) |   | June                  12, 2007 |
|                                                                                                   |                                                                                                                                                                  |   |                           |
| /s/                  CHARLES A. BAKERCharles                  A. Baker                                 | Director                                                                                                                                                              |   | June                  12, 2007 |
|                                                                                                   |                                                                                                                                                                  |   |                           |
| /s/                  MARK F. DALTONMark                  F. Dalton                                     | Director                                                                                                                                                              |   | June                  12, 2007 |
|                                                                                                   |                                                                                                                                                                  |   |                           |
| /s/                  STEPHEN P. GOFF, Ph.D.Stephen                  P. Goff, Ph.D.                     | Director                                                                                                                                                              |   | June                  12, 2007 |
|                                                                                                   |                                                                                                                                                                  |   |                           |
| /s/                  DAVID A. SCHEINBERG, M.D., PH.D.David                  A. Scheinberg, M.D., Ph.D. | Director                                                                                                                                                              |   | June                  12, 2007 |
|                                                                                                   |                                                                                                                                                                  |   |                           |
| /s/                  NICOLE S. WILLIAMS                                                                | Director                                                                                                                                                              |   | June                  12, 2007 |
| Nicole                  S. Williams                                                                    |                                                                                                                                                                  |   |                           |