## Date: S ubj ec t: UN IT E D STATES ENVIRONMENTAL PROT ECT I ON AGENCY WASHINGTON , 

### O .C. 20460



## l 0-March-20 1 5 O FFI CE OF C HEMI C AL SAFETY AND POLLUTION l'R EVENTION 

## S pinosad/S pinetoram . Dietary Risk Assessment in Support of the Proposed Application to Coffee; Label Amendments for P lum / Prune and 

## Brassica (Co le) Leafy Vegetables Crop Group 5 ; and Updates to the Crop Group/ Subgroup Commodity Definitions for the Followin g: Bulb Vegetable Crop Group 3-07 ; Fruitin g Vegetable Crop Gro up 8-10 ; Citrus Fruit Crop Group I 0-10; Pome Fruit Crop Gro up 11- IO ; S ton e Fruit Crop Group 1 2-12; Cane berry Crop Subgroup 13-07A; Bushberry Crop Subgroup 13-078 (except l ingonberry); S mall Fruit Vine Climbing , Except Fuzzy Kiwifruit , Crop Subgroup I 3 -0 7F; Low Growing Berry Crop Subgroup 1 3 -070 (exce pt cranb e rry and lowbush b lueberry); Tree Nut Crop Group 14-12 ; and Cottonseed Crop Subgroup 20C.

C Codes: I I0008 and I I0003 DP Barcodes: 

### 0423657 D ec isio n Nos.: 

### 483254 and 

### 483225 R e is tr atio n Nos.: 

### 62719-541 , 6 27 19-545 , and 

### 62719-621



## Reviewerffo: Tom Bloem ,**emi "**  

## Through: R isk Assessment Branch 1 / l l0t!lth Effects Di vision (RAB 1/HED: 7509P) Julie Van Alstine , Environmental H ea lth sc· 6/ HED

# ~ 

# V**Ck\.-~** Seyed Tadayon, C hemi st, RAB5 / HED**~".?--** 

## Dietary Exposure Science Adv isory Counc · George F. Kramer , Ph .D . , Senior**Chemist ~~~~<2:>"~~--**  

## RABl/H E D (7509P) 

## Exec utive Summary HED concluded that spinosad ( PC code

- 110003) and spineto ram (PC code

- 1 l 0008) are toxicolog ically equivalent (see r isk as s essment D33 I 741 , P . S hah 

## e t al., 20-Sep-2007); therefo re , exposures to the se compounds were combined. As a result of the proposed app l ication of sp ino sad/s p inetoram to coffee, label amendments for plum/prune and 

## Brass ica (Co le) leafy vege table s crop group 5; and the proposed upd ates to several crop group / s ubgroup commodity definition s, a chronic di e tary risk assessment was conduc ted u sing the Dietary Exposure Evaluation Model

- Food Consumption Intake Database ( DE EM-FC ID , ver. 3.16) wh ich incorporates food consumption data from the United States Department of Agriculture (USDA) National Health and Nutr iti o n Exam inati on Survey , What We Eat in America (NHANES / WWEIA ; 2003-2008). Acute and canc er ana l yses were not conducted as t ox ic o logical effects attributable to a s ingl e do se we re not id entified and spine toram and spinosad a re classified as n ot li ke ly t o be carc in oge n s (cancer risk assess me nt is not required).

Pa ge I of24

### Spinctoram and Spinosad Dietary Exposure and Ri sk Assessment 04 23657 

## The chronic ana lysis assumed 100% crop treated , average field-trial res idues or tol erance-level resid ues for crop commodities, average residues from the livestock feeding study, s pinosad residue estimates for fi sh/shellfish (res id ues of sp in eto r a m in fish/she ll fish are expected to be insign i ficant) , ex pe rim ental processing factors when available, and modeled drinking water estimates. The re su lting chronic exposure est i mates do not exceed HED' s lev e l of concern (:S64% chron ic popu lation-adjusted dose (cPAD); c hil dren 1-2 years old were the most highly exposed subpopulation). I. I ntrod ucti o n 

## Dietary risk assessment incorporates both exposu re and toxicity of a given pesticide. For acute and c hronic assessments, the ri sk is expressed as a percentage of a maximum acceptable dose ( i . e., the dos e which H ED concluded wi ll result in no unreasonable adverse hea lth effects). Th is dose is refened to as the PA D . T h e PAD is eq ui valent to the point of departure (POD, NOAEL , LOAEL , e.g.) divided by the required uncertai nty or safety factors. For acute and non-cancer chronic exposures, HE D is concerned when estimated dietary risk exceeds 100% of t he PAD. References whi c h d i scuss the acute and chron ic ri s k assessments in more detail are available on the EPNpesticides web site: "Avail able lnfonnation on Assessing Exposure from Pesticid es, A User's Gu ide ," 2 1

- Jun -2000 , web li nk: h ttp: //www.regulat ions.gov/# !documentDetai l ;D=EPAHQ-OP P-2007

- 0780-000I ; or see SOP 99.6 (20 -Aug-1 999). The most r ece nt s pinosad / spinetoram dietary exposure analys is can be found in D3809 1 5 

## (T. B loem , l 8-A ug20 1 0). II. R es idu e Inform at i on 

## Residues of Concern in Plants and Livestock: HED concluded that sp in osad (co n sists of two re l ated active ing r ed ie nts: spinosy n A a nd spinosyn D; PC code 110003) and spinetoram (consists of two re lated active ingredient s: XDE-175-J and XDE-175-L; PC code: 110008 ) are toxicologically equ ivalent (see risk assessment D33 l 74 I , P. Sha h 

## el al., 20-Sep-2007). The res idue s of concern in pl ants, li vestoc k , · and water follow ing application of spinetoram o r spinosad are as described in Tables l and 2 , respectivel y . Tab l e I : R es idu es fo r T o l era n ce Ex p ress i o n a n d Ri s k A ss essme n t for Sp in etoram. Matrix Residue s I nc luded in Ri sk Assess ment Re s idue s I ncluded in Tolerance Expre ss ion Plants 1 XDE-175-J, XDE

- 1 75-L, ND -J. and NF-J XDE-175 -J. XDE-175 -L. N D-J. and NF

- J Ruminant 1•2 XDE-175-J. XDE-175-L. ND-J. and NF-J XDE-175-J. XDE-175-L . ND-J . and NF-J H en 1

· 3 XDE-175-J. XDE-175

- L . ND-J. NF-J. 3'-0-deethyl- 175-J . 3'-0- XDE

- 175-J . XDE-175-L. ND-J. and Nf-J dccthyl-175-L. and O -d emcthyl-175 -L 2 Rot atio nal C rop s 1 ca n n o t be determined from the available data since identified or partiall y identified degradates in th e fate s tudies Drinking Water 1 contained the major ring s tructures ofthc parent compound. a total 

## -- re s idue method was used in modeling 1 Sec ri sk assessment 033 1741 (P. Sha h e l 

### al .. 20-Sep-2007) for more information. 2 Feedin g stu die s s hould do se with parent (XDE- 1 75-J and XOE-175

- L) and monitor for th e residues of concern for risk assessment. 3 0-demethyl-175-L i s either 2·-0-dcmcthyl-175-L or 4 ·- 0-dcmet hyl -1 75-L or a mixture of both.



### Page 2 of24

### Spi n e t ora m and Spin osad Di et ary Exposure and Ri sk Assessment 

### 0423657 Table 2: Res idues for Toleranc e Ex pre ssio n a nd Ri s k Ass ess me nt for Spinosad. Matrix Residue s Included in Risk A sse ssment R es idue s Included in Tolerance E x pressi o n Pl a nts' spinosyn A and D spinosyn A and D I log and Rumin a nts ' oral and dermal

- s pino sy n A and D oral and dermal

- s pino sy n A and D oral

- s pino sy n A and D: dermal kxcluding li ver)

- sp inosyn A Poultry l.2 and 0: dermal (liver)

- s pino syn s A. B. 0. 1. 

### N-clemethy l D. and oral and dermal s pino sy n A and 0 .\'-dcmethyl J Rotational Crops 1 

### spi no syn A and D spinosyn A and 0 Drink in g Wate r3 total spinosad 

# -- adjustment of the TR Rs in the edib l e ti ss ue s from the spinosyn A Fish / Shel I fish 4 

### bioconcentration s tudy ( 19 ppb d ata ) for the water concentration spinosyn A and D re sultin g from the m o squ it o larvie i de use 1 

### Sec 02438 16 (G . Herndon. 03 -Mar-1998 ) and 0264984 ( W. Donovan. I 4-Jun

- 200 2 ) for more inforniation. :: Sec D3 7-1794 (T. Bloem. 25-Mar-20 I0) for more informa t io n. 3 

### See 0316077 

# er . Bloem e t al . . 

### 02-Aug-2006 ) for more information. 4 

### I IED no tes that the se conclusions are appropriate for this mosquito larvicidc peti t ion only and wi ll be reeva lu ated if th e petitioner alte rs the aquatic application sce nar io: sec 031 6077 (T . Bloem e t al. 

### 02-Au g- 2006 ) for more information. 

## Tolerances R ecommended as a Res ult of the Pr oposed Use: The Interregio nal Research P roject No. 4 ( IR-4 ) requested Sec tion 3 R egis tration s for fo liar application of s pino sad and spine toram to coffee. IR-4 is also requ esting spinosad and spi netoram label amendment s wh ic h reduce the preharvest inte rval (P H I ) 

## for plums / prun es fro m 7 day s to I day and pe rmi t app li cat io n s directed to the ba se of 

## Brassica (Co le) leafy vegetables group 5 crops (on ly fo li a r appli cation is currently registered). F in all y, IR -4 i s requestin g to update ex is ting s pinosad and s pinetoran1 crop group/ subgrou p tolerance com m odity defin i tions to the fo ll ow i n g: bu lb vegetable crop group 3-07; fruiting vege tabl e crop gro up 8-1 O; c itru s fruit crop group 10-10 ; pome fruit crop group 11

- 10 ; s ton e f ruit c rop g roup 12

- 12 ; cane berry crop subgro up 1 3-07A: bushberry crop s u bgrou p 13-07B (exce pt li ngo nb e rry); small fruit vi ne climbing, exce pt fuzzy kiwifruit , crop s ub g roup 13 -07 F ; low growi n g b erry crop subgroup 1 3-070 (except cranb erry and lowbush blu e berry), t ree nut cro p group 14- 1 2; and co tto n s e ed crop s ub g roup 20C. Table 3 is a s ummary of th e HED-rec o mm c nded tol eranc es co n cernin g th ese actions (0416068, T. Bl oe m , I 0 -M ar- 20 1 5). It 

## is noted that the cu rrentl y - estab li s hed s pino s ad and spi netor am sto ne fruit and c r op gro up 5 t o lerances are ad equate to cover the propo sed lab el amendme nt s. In ad diti o n , th e changes to so me of th e crop gro up/ s ub g roup to le ra nc e val ue s li sted in Table 3 is as a result of harmonizing th e tolerance values w ith the curren tl yestab li shed Canadi an and/ o r Codex m ax imum res idu e lim i t s and not a re s u lt of an amended applicat ion sce nario . With the estab li shment of th e toleran ces li s t ed in T able 3, the fo ll ow in g s pinosad and s pin e toram to l e ran ces will be de l ete d: co tton , und e l inte d see d ; cranberry; grape; juneberry , lin go nb erry; okra; o nion , green; pi s tac hi o; sa la l ; s trawberry; vegetab le, bu lb, gro up 3, exce pt g reen onion: vege tab l e, fruiting , group 8 ; fruit , c itru s, group l O; fruit pome, group 11 ; fruit s tone, gro up 12; canebe rry, s ub g roup l 3A; bu s h ber ry , s ub g roup 1 3 B ; and nut , tree , group 14.

Page 3 of24

### Spinetoram and Spinosad Dietary Expos ure and Ri sk A s sess m e nt 0 423657 

### Tab le 3: To lera n ce S umm ar y. C omm o dity H ED -Recommendcd Tolerance (ppm) S 1

>i n osad (40 C FR 1 80.495(a)) Co lTe c. g ree n bean 0.0.t Oni o n. bulb. s ubaroup 3

- 07A 0.10 Onion. arcen. s ub a roup 3 -0 78 4.0 Vcaetablc. fruitina. group 8 -1 0 0.40 Fruit . c itru s . gro up I0-1 0 0.30 Fruit . oome. grouo 11-10 0.20 Fruit. s tone . gro uo 12- 1 2 0.20 Caneberrv s ubgroup 13-07A 1. 0 Nut. tree. 11.ro uo 1 4 -1 2 0. 1 0 Co tt o n seed s ubl!.rouo 20C 0.02 B u s hberr v. s ubgroup 1 3-078. except li ng onbcrry 0.40 Fruit . s mall. vine c limbing. excep t fuzzv kiwifruit, subgroup I 3

- 07F 0.5 0 Graoe. rai s in 1.0 Berry , low growi ng , s ubg roup 13- 07G. excep t blueberry. lowb u s h a nd cranbe rry 0.90 Soinctoram ( 40 

### C FR 180 .635(a)) Coffee. green bean 0.04 On i o n. bulb. subgroup 3-07A 0.1 0 Oni o n. 2r e en. s ubgroup 3

- 078 2.0 Vegetable. fruitinl!.. grouo 8-10 0.4 0 Frnit, eitrn s . gro uo 1 0 -1 0 0.30 Fruit. oome. gro uo 11

- 10 0.2 0 Frnit. s tone. grouo 1 2 -1 2 0.30 Cancbe rry s ubgroup 13-07A 0.80 Frnit. s mall. vine climbing. exeeot fuzzv kiwifrnit. s ubgroup I 3

-0 7 f 0.50 Nut. tree. l!.roul) 1 4- 1 2 0. 10 Cottonseed s ubaroup 20 C 0. 04 Bu s hberrv. s ubaroup 1 3-078. except linaonberry 0.50 Berrv. l ow gro wi ng, s ubgroup 13-07G. except blueber ry . lowbu s hand cranberr y 0.90 

## Food R es idu es u sed in th e Chroni c A nal ys i s: HED conclud e d that sp in osad and sp ine t oram are toxicolo g icall y equivalent and that ex po s ure s to these compounds sho uld be co mbined (see risk assess ment D33 1 74 l , P . S hah 

## e t al. , 2 0- Sep

-2 007 ). Th e pre vious as se ssment incorporated US D A P estic ide D ata Pro g ram ( PDP ) res idu e dat a for se lected co mmod i ties and pe rc e nt crop treated data when calcu lating th e li ves to ck dietary burden es tim ates. The se re fin e m en t s w e re in co rporated in to th e previous assessme nt as the dietary estimates were agg regated w ith re s identi al exposure estim ates res ulting from a cat spot - on use w hi c h emp lo yed conservative default ass umpti ons. S inc e thi s assessment , th e reg is trant as s ubmitte d an ai s peci fie study concerning ex po s ur e from the cat spot- on u se w h ich y ie ld s lo we r reside nt ial ex po s ure es tim ate s making incorporation of th ese refinement s unnec ess ary. Th e curre nt anal ys is a ss umed 100 % crop treated fo r all co mm oditi es; ave rage s pin os ad fi eld-tri a l re s idu es (see Tab le 4) or spi no s ad tolerance-level residue s fo r cro p commodities (40 CF R 18 0.495); sp in osad re s idu e estimates for fish/shellfish (see T abl e 5): expe rim e ntal s pin osad pro cess in g facto rs. when avai lable ( DEEM ver . 7 . 8 1 default s as s umed for all o th ers); and re fined milk , egg, and rnminan t/ hog/ po ultry tis s ue spi no sad res idu e es timates (see T ables 6 -11 ). H ED conc lud es th a t th ese ass umpti o n s are appropri ate for combined sp ino sad and s pin e toram re s idu es fo r the fo llowin g rea so n s: Page 4 of24

### Spinetoram and Spinosad Dietarv Ex po su re and Risk Assessment 0 423657 

## (1) 

## Spinosad is r eg is te r e d for app li cation to a ll of the c rops th at sp in etoram i s registered for application to with s imilar preharvest and retreatment inte rvaJs a nd a ppli cation rat es 2'.: 

## to the sp ine toram app li cati o n rate s. B ased on the s pinosad and sp inetoram appli cat io n scenarios, the ne a rl y id ent ica l structure fo r s pino sad and s pin e toram , and the s ide-b y -sid e spino sad and spine to ram re s idu e dat a w hi ch resu lted in s pinetoram residues 

## S spinosad residues, HED co nclud e d th at tran s l at ion of the sp in osad r es idu e data to s p in e t o ram was acce ptabl e (D325387 , T. Bl oem, 1 2-Sep-2007). Si nce both products co ntrol the s am e pest s pecies , H ED concludes that it i s unlike l y that s pin etoram and sp in osad w ill be ap p li e d to th e same crop. T he re fo re , HED conc l udes that th e s pino sad residue d a ta a re an acceptab le es tim ate fo r p o t e nti a l spinosad or sp in e to ram res idu es. H E D n o tes that limit of quantitati on to lerances are establi s hed for both spinosad and spinetoram i n/on asparag u s, sweet co rn , cottonseed , cranberTy , peanut , pin eappl e, soybean see d , and s ub g roups 68 and 6C (sp ino sad and s pineto ram ). Since sp ineto ram incl udes fo ur comp ou nd s as resid ues of concern whi l e sp in osad in c lud es two , th e s pin etoram toleranc es se t at th e limit of quant i tation ( LO Q) are higher and were as s um ed in the ex posure analysi s . Al so, th e c urre ntl y e s tab li s he d s pinosad feijoa to lerance of 0.05 ppm is in correct and sho uld be 0.30 ppm ( 0 2524 16 , G. Herndon , 23

- Feb

- 1999; 0 249374, M . D o herty, 20-Aug-1998). F inally , du e to tol era nce harmon izati on, the sp in etoram to lerance for subgroup l 3-07B are hi g her than that for sp in osad and were t he refore incorpo rate d into th e as s essment. (2) H EO co nc lud e d that th e s pin osad proc ess in g factors a re adequate for both spino sad a nd sp in etoram ( 0357703. T. B loe m , 28-Apr-2009). (3) Tables 6- 11 are su mmaries of the sp in os ad li ves toc k res idu e estimates . The li ves to ck d ie tary burden estim ate s were ge ne rate d ass umin g 100 % crop treated and e ith e r t o le ranc e o r average field tri a l residues; th e res ulting d ietary burden s were then used to e s timate sp inosad re s idue s in the var io u s liv estoc k commoditie s u s in g average residue s from the s pino sad feeding s tud y. Although th e liv es tock d ietary burd e n s pre se nted in Tabl e 7 are not th e m ax imum theoretical , the li vestock re s idu e estim ates in corporate d into th e assess ment arc co n servati ve for the foll owi ng rea so n s (no te that based on toxicological cons id e rations , o nl y a c hronic a na lysis i s necessary): ( 1 ) th e dietary burden calc ul ati o n s a ss umed 100% crop treated ; (2) the re s idue es timates assumed that all li vestoc k a re ex po sed to the pre mi se ( rnminant) o r dennal/ pre mi se ( poultry) s pinosad application scenarios ( the se app li cati on sce nari os are not r eg iste red for spi ne to ram ); (3) the s pino sad and s pin e toram rnminant f ee din g s tudi es resu lted in s imil ar tran s fer coeffic ients; and (4) based on the sp inetoram poultr y d i e tary burden , r es idu es of s pin e toram are ex p ec t e d to b e in s ignificant ( 0 353933, T . Bl oe m , 28-Aug- 2 008).

P

age 5 of24

### Spinetoram and Spinosad Dietary Exposure and Risk Assessment 04 23657

Tab l e 4: S umm a r y o f R e fi n ed Co mb ined S pin osy n A and D R es idue Estimates Use d in th e Ana lys i s. crop group/ m a trix crop/ commodity re s id ue (ppm) reference refined food c rop residues ga rden beet 0.032 average spi no sad garden beet (translated to s u gar beet). radish. and root and tub er potato field trial residue (0279683. W. Donovan. 

### I O-Jul-2002): vegetables (group I ) radish and carrot 0.017 radish re s idue translated to carrot based on 0 2524 1 6 

### (G. I krndon. 23-Fcb-1999): tolerance le ve l re s idues assumed for the remainin g potato 0.005 commodities s pinach 3.961 leafy vegetables head lcllucc w / o wrapper leaves 0.796 average licld trial re sid ue s (0237752. 

### G. H erndon. 2-Mar-1998): (except 

### Brassica; l eaf l ettuce 3.488 applied to the remaining crops in this crop group u s ing 

### SOP group 4 2000.1 celery 1.026 broccoli 0.3 1 3 average field trial re sid u es (0228434, S. Willett. 23-Jan-1997: 

### Brassica (eole) leaf y cabbage w/ o wrapper leaves 0.08 1 0416068. T.131oem. I O -M ar-20 15 ): applied to the remaining vegetables (group 5) mustard g ree n s 4.000 crops in thi s crop group using SOP 2000.1. The leg ume vegetables s nap bean 0.066 average field trial resid u es (0249374. M. Doherty. 24-Jun-1999: (group 6a ) s now pea 0.087 0280315. W. Donovan.29-Aug-2002) tomato 0.053 average field trial re s idue s and tomato paste (2. 1 x). puree (0. 7x). fruiting vegetable (group 8-10) p eppc r(bcll) 0.054 and juice (0.3x) processing factors (0232203. 

### G. Herndon. 2 -M arpepper (nonbdl) 0.110 1998): applied to th e remaining crops u s ing 40 CFR 180.41 cucumber 0 . 046 average field trial residues (0249374. M. Doh e rt y . 24-Jun-1999 ): cucurbit vegetables muskmelon 0.094 applied to the remaining crop s in thi s crop group u si n g SOP (group 9) s ummer s quas h 0.028 2000. 1 grapefr uit 0.057 average field trial resid ue s and orange juice (0. 1 x) proces s ing citru s (group I0- 1 0) lemon 0.068 factor applied to all citrusjuice ( 0237752. 

### G . I lernd on . 2-Marorange 0.085 19 98): app lied to the remainin g crops u s ing 40 CFR 180.41 apple 0.028 average apple field trial re s idue and apple juice proce ss in g factor pome fruit (0.1 x : 0228434, S. Willett, 23

- Jan-1997) and average pear field (group 11-1 0) pear 0.029 trial re s idue ( 0272706. 

### G. Hernd o n. I 6-Feb -2 00 I ) : applied to the r e mainin g crops in this crop group usin g SOP 2000. I peach 0.092 average field trial re s idue s and prune proces s ing factor (I .3x : 0 249374. M . Do herty. 24-Jun- 1 999: 0304416. W. C utchin. 14- Feb-1999: 0366968. T . Bloem. 2-0cp-2009: 0416068. 

### T. Bloem. s tone fruit c herry 0.068 I 0-Mar-20 1 5): app li ed to the remainin g crops using 40 CFR (gro up 12-1 2) 18 0.41. For fre s h prune. an e s timate of 0.063 ppm was u se d in p lum / prune fresh 0.041 previo u s asses s ment which was derived from s ample s treated at 3 . 5x the registered rat e ((PH I= 7 day s). The cu rre nt value is bas ed nectarine 0.073 on plum s ample s treated u s in g the regis ti:rcd application scenario ( I x: PHI = I day). co rn g rain 0.5 1 0 Average residue s followin g po s t-harve s t s pino sad treatment of the grain (030420 I. W. C utchin. I 3-0ct-2004): I IEO notes that foliar wheat g rain 0.551 appl icati on of s pino sa d t o cereal g rain s i s also reg i s tered re s ultin g in < LOO re s idues in g rain: therefore. the average re s idue s cereal gra in re s ultin g from only the po s t harve s t treatment are acceptable (g roup 15 ) barley gra in 0.652 (tolerance l eve l re s idue s a ss umed for tho se commodities not li s ted ). The following corn a nd wheat processing factors w ere oat grain 0.495 in cluded (0304201. W. C utchin . 1 3-0ct-2004): corn meal

- 0.26x: com flour

- 0.22x. com oil

- 

### I .2x. corn s tarch

- 0.0 I x rice gra in 0.664 (translated to co rn sy rup ). wheat Oour

- 0.32x. and wheat g erm - 0.54x. basil fre s h 1.200 average field trial re s idu es (D278777. W. Donovan . I O-Ju l-2002: herb s (group I 9a) 0312374. 

### T. Bl o em. 20

- Jul y -2005 ) : b as il re s idues translat e d to basil dried 13.920 re mainin g herb s based on 02524 1 6 

### (G. Herndon. 23 -Feb-1999 ) 

## Page 6 of24

### Spineto ram and Spinosad D ietary Ex po s ure and R isk Assessment 04 23657 Tabl e 4 : S ummar y of R e fin e d Combin e d S pino sy n A and D Resi du e Es t i mate s Used in t h e A n a l y s is. crop group/ matrix crop/ commodity re s idue (ppm) refere nce spices (excep t black ave r age fi e ld tri a l res idu e (033 5 084. 

## n . H anson. I 7

- Sep -2 007): pepper: grou p l 

### % ) dill seed 0.18 dill seed residue tran s lated to remaining s pices (except black pepper) b ased o n 02524 16 (G. l lcrndon. 23

- Feb- 1 999) sma ll fruit vine climbing except g rap e 0. 1 5 average fie l d tr ial re s id ue and rai s in ( I .62x) pro cess in g factor fu zzy ki wi s ubgroup (028 1 6 16. W . Donovan. 1 5-Aug

- 2002). I 3-07f low g rowin g berry s trawberry 0.252 average field trial re s idue (4524470 l.d er.wp d ): translated to the subgro up I 3

-07g remaining crops i n the s ub gro up



### .. banana and plantain 0.084 average field tri al re s idue (03 123 74. 

### T. Bloem. 20

- Jul-2005: 0323723. T. B l oem, 2 -F eb

- 2006) fi s h /s hellfi s h



### .. fi sh/s hellfish (ex cluding t una) 1. 24 sec Table 5 below poultry/ho g/ rum i nant meat 0.093 poultry fat 0.473 liver 0 . 259 Sec T ables 7. I 0. and 11 . eggs 0. 1 34 kidne) 0 . 072 hog liver 0.106 See Tables 6-9. mu scle 0.0 16 fa t 0.39 2 kidney 0. 1 57 li ve r 0.268 muscle 0 . 0 -1 6 ruminant fat 1.01 0 Sec Tables 6-9.. \\hole milk 0.29 1 sk im mi lk 0 . 060 milk fat 3.635 

### T a bl e 5: R es i d u es i n/ o n Fi s h /S h e ll fi s h fr o m th e Mo s quit o L arv ic id e Use. El'ED provided HED with th e following total sp in osad water co ncentrati ons re s ultin g from th e s pinosad mo sq uit o l arvicidc applica ti on scenario (20 x 0. 10 lb ai /acrc: 

### RTI = 7 days: 0331271. Ronald Parker. 28 -Jul y-2006): peak

- 489 ppb: ann ual ave rage 472 ppb. The water numbers were generated u s ing th e PRZM /E X/\MS model s and ass umed a uniform I 0 c m wat e r column and s ta ti c conditi ons (no now through o r dilution) . I IED concludes that the se estima tes are conservative for the following reasons: ( I ) mosqui t o larvae p redominate in areas s h e lt ered from wind and wave ac tion: therefore treatment of an t:ntirc body of water i s unlikel y and dilution of treated w ith untreated watt:r will lik ely occur: (2) s t at i

c conditions (no inflow or outOow): and (3) uniform I 0 cm \\ater depth . To estimate residue in fish/ shellfish. HED concluded that a I meter water depth was more realistic; th erefo r e . 1IED divided th e 472 ppb an nu a l average provided by EFED ( unifonn I Ocm depth a ss umed ) by I 0 ( 47 .2 ppb). Based o n th e to tal radioacti ve res idue 

### (T llRs) of

- 0.50 ppm in the ed i ble ti ss ue from the s pino sy n /\ 1 9-ppb fish bioconccntration s tud y and the 47.2 ppb water estimate. a fish/ s hellfi s h re s idue cs 1ima1c of 1. 24 ppm was calculated (0.50 ppm 

### x 47.2 ppb + 1 9 ppb 

### = 1. 24 ppm) . 13ascd o n t he fate propert i es for s pino sa d. 1IE D concluded that re s idu es in tun a wi ll be in s i g nificant. See 0316078 (T. B l oem. 2-Au g -2 006) for further infonnation on the fish biococnetration s tudy . H ED notes th at th e 1. 2-1 pp b re s idue es tim a te is very co n se rvative in that it a ss um es that all cons umed fi s h /s hellfi s h (excluding tuna) li ve in I mete r deep w a ter tha1 is trcmcd at th e m ax imum proposed m osqui to larvicide application rate (no dilution with umn:atcd water).



### P

age 7 of24

### Spinetoram and Spinosad Dierary Exposure and Ris k Assessmenr 0 42 36 57 

### Tabl e 6: R es idu e s in/o n Beef C attle , Diary Cattle , and Hog from Premi se Treat me nt. Residues followin g o nl y premise application are not available: therefore. MED u se d the demial pour-on re s idue d ata as a s urroga te as follows. Be e f / Da iry C att l e - Premi s e label indicate s that I gallon of 1600 ppm solution may be ap plied to 50 0 

### ft 2 ( 1 2. 12 mg/ft2 ) 1

. If the fo llowin g arc assumed . a dermal applica tion rate of 485 mg/anima l can be calculated: 1 0 app lication s . I 0% of the s pray s olu t ion reache s the cattle. and 40 l l2/animal. The 485 m g/a nimal derm al dose as a re s ult of the premi se s pra y app lication repre se nts 9.7o/cJ8.2% th e beef / dairy cattle application rate pe r form ed in the de nnal magnitude of the re s idue s tudy ( s ec below ). Multip l y in g the average residue from the dermal magnitude of the re s idue s tudy b y the s e facto rs yie ld s the followin g resid ues: milk- 0 . 0 1 5 ppm. s kim mi l k

- 0.011 ppm. muscle

- 0.014 ppm, kidney

- 0.049 ppm , liver 0.072 ppm, and fat

- 0.131 ppm. H og - Premi se lab e l indicates that l gallon of 160 0 ppm solution may be applied to 5 00 

### ft 2 ( 12 . 12 mg/ ft 2 ) 1

. If the followin g arc assumed , a derma l appl i cation rate of 97 mg/animal can be calcu l ated: I0 app lication s . I 0% or the spray so lution reac hes the hogs, a nd 8 ft 2/ animal. The 97 mg/a nimal re pre se nt s 2 % the beef catt l e application rate pcrfom1cd in th e derma l magni t ude of the residue s tud y ( s c.:e below). Multiplyin g the average re s idu e form the dermal magnitude of the residu e s tud y by the s e factors y ields th e following residue s: mu s cle

- 0.003 ppm. kidney - 0.0 I0 ppm . liv e r 0.0 I 5 ppm . and fat

- 0.027 ppm. S umm ar y of th e D e rm a l Pour-o n Ma g nitud e o f the Re s idue Data

- Beef and dairy cattle were treated with 

### 5 dermal p o ur- o n applicat ions o f s pino sad at 2 mg a i /kg ( retreatmcnt interval ( RTI ) = 14 day s: 02649 84 . W. Donovan . I 4

- Jun-2002 : 45080605). 1IED notes that the s tudy incl u d ed a pre mi se application and that thi s contributed an unknown amo unt of s pino sad to th e to tal dose per animal ( 80 0 ppm so luti on applic.:d every 7 days to th e point of run-off). Based on t he dcmial application rate of 2 mg ai/kg and default beef / dairy cattle wei g hts of 

### 500 1 59 0 kg/animal (from 

### 13 . Sc hneider 1 IED: 0334930. T. Bl oem. 28-Feb-20 0 7 ): beef

- 

### 5 app s x 2 mg ai/kg x 500 kg/animal = 5000 m g/anima l : dairy

- 

### 5 apps x 2 mg ai/ kg x 590 kg/ animal = 5900 m g/ani1ral. The fo ll owing average re s idues wc.:re ob s erved: milk

- 0.182 ppm , skim milk

- 0 . 140 ppm. mu s cle

- 0. 144 ppm. kidney

- 

### 0. 505 ppm. li ver 0. 743 ppm. and fat

- 1 .3 53 ppm. For derivation of the s kim milk re s idue sec D354053 (T. B l oem. 26

- Jun-2008 ). 1IED note s that the s tud y e mployed a 2-day interval from final application to sacrifice: howe ve r. l-I EO concluded that the s e dat a were s ufficient to repre se nt re s idu es in / o n the day of linal aoolication ( 0321764 , T. Bloem. 2-Feb

-2006). 1 11 ED note s th a t th e premi s e lab el doc s not re s trict the total number of applications. However. the applica ti o n of I ga l l on o f a 1 600 ppm so luti o n to 500 ft 2 is fo r se ve r e infes tation s only ( normal application is I ga llon of 800 ppm so lution app li ed to 500 -1 000 

### ft 2 ). Tabl e 7: Ca lc ul ati o n o f R easo nabl y Bal a n ce d Di e t a r y Burd e n s . Feed Commodi ty ' % Drv Mattc r2 % Diet 2 Re s idue (oom) J Di e ta rv" B ee f Ca ttle field com grain (cc) 

### 88 80 0.5 1 0.464 nax meal (pc) 88 

### 5 0 . 02 0.00 1 trefoil hay ( rl 85 15 7.355 1. 298 water ( from mo s quit o u se) 5 0.0472 

### x 135 + 9. 1 x 0.5 0.350 di et a r y burd e n 

# -- -- -- 2. 1 1 3 Dair v C attle S orghum grai n ( cc ) 86 45 0.664 0.347 A lfalfa meal (pc) 89 1 0 7.355 0.826 Grass forage ( r) 25 45 2.06 3 . 708 water (from mo s ouito use) 5 0.0472 x 135 + 24 x 0 .5 0. 133 dieta r y burd e n 

## -- -- 

# -- 5. 014 Ho2 So rghum grain (cc) 86 80 0.664 0.53 1 Wheat milled b v oroducts (eel 88 

# s 0.887 0.044 Alfalfa mea l (oc) 89 

# s 7.355 0.368 Field o ea (oc) 90 10 0 .0 2 0 . 002 water (l"rom mo s quito u se) S 0.0472 x 9 + 2 x 0.5 0.106 d i

e tar y b ur d e n 

## -- - - - - 0 .9 84



### Page 8 of24

### Spinetoram and Spinosad Di e tary Ex po sure and Ri sk Asse ss ment 

## 04 23657 Table 7 : C alcu la tion of Reaso nabl y B a la n ced Dietary Burden s. Feed Co mmodity' % Dr y Maner %D iet 2 

### Re si due (ppm) 3 

### Poultry Sorghum gra in (cc) 86 75 0.664 Al falfa meal (pc) 89 5 

### 7.355 Saffiowcr meal (pc) 9 1 20 0.02 \\atcr (from mo sQ uito u se) 5 

### 0.0472 x 0 . 23 + 0. 1 4 x 0.5 dietary burden 

# -- - - 1 

### R = roughage: CC= carbohydrate concentrate: PC= protein concentrate . 2 

### r ev ised O PPT S 860.1000 Table I f cc ds tulT s (Jun e 2008) 

## -- Di etary4 0.498 0.368 0.004 0.039 0.9 76

3 

### Tolerance -l evel residues assumed for field pea. saffio "cr meal. and nax meal. Average s pinosad residues as s um ed alfal fa hay (46 1 5950 I 

### .der.d oe; tran s lated 1 0 

### trefo il hay). grass forage (46 17370 I 

### .dcr.doc). so r g hum gra in (46 248 50 I 

### . der.d oc). lidd com g rain (4624850 1.d er.doc) . wheat grain (030420 1. \\I . 

### Cutchin. 13

- 0ct-2004 : l.6Jx average wheat bran processing facto r) . and alfalfa meal (hay data: 46 1 5980 1. der.doc). 4 

### dietary co ntribution = residues+ % dry matter x 

### % 

### diet (%d r y mailer not included in hog an d poultry calculations). 5 

### Esti mat ed concentration in livestock drinking water with sp in osad re s idues at 0 . 0 4 72 ppm from th e mos quito larvi c idc use (see T able 

### 5 fo r derivation of thi s re s i due): ass ume s that water arc treated for o nl y h alf th e year (0.5 factor): assu me s 13 5 kg of water con s umed per day and 24 /9. 1 k g d r y matter per day for dairy/beef cattle ( from 0334930. T. 

### 13 1 ocm. 28 -Fcb -2007): ass um es 0.23 kg of water consumed per day and 0. I 4 k g feed intake p er day for po ultry (f rom PP# IF0399 I . G. Otakie. 4

- Sc p- I992): assumes 9 k g of water co nsu med per day an d 2 kg feed int ake per day for hog (taken from Ontario Fann A nimal Co uncil http: // www.ofae.org/factsh ects/fact 13.html ) 7 

### I 

### JED notes that previou s assess m ents used the average mustard g r een r esid ue s**a~** 

### a s urroga te for leaves of root and tuber vegetable s in the ruminant d iets : HED**a~** 

### s ince fou nd gard en bee t top da ta and used the average residue from these data (J.468 ppm: MRID 45285102 : 0279683. W. 

### Don ovan . 1 0 -J ul-2002) ra1her than the average mu stard g n:en residue (3. 1 ppm). T able 

### 8: S ummar y of Rum in a nt Feedinl!. Study a n d Pr o i ec ted Re si due s i n Cattl e and H oe Ti ss u e and M il k. 

### f ee din g. lev e l (p pm) 1 

### linear reg re ssio n (r 

### = 0.999) projected re sid ue s (pp m ? I 3 10 avcrage co mbin ed s pin osy n A 

### and D 

### re s idue (ppm) s lo pe intercept cattle h oa kidn cv 0.047 0. 1 63 0.445 0.0 432 0.0 168 0. 108 0.062 l iver 0.095 

### 0.273 0.98 1 0.099 1 -0.0 130 0 . 196 0.091 mu s cle 0.0 1 8 0.041 0.178 0.0 182

- 0.0062 0.032 0.0 13 fat 

### 0.5 4 4 l.0.f7 4.753 0 .48 38 - 0. 1 431 0.879 0.365 whole milk 0.049 0. 157 0.559 0 .0 57 -0.0 10 0.276 

# -- skim milk 0.008 0.0 19 0.095 0 . 0 11

- 0.0059 0.049 

# -- I 

### D26968 I ' M. Doherty, 23-0ct-2000.

projected residues in ti ss ue s based on dietary burdens (sec Table 7: re si due = dietary burden 

### x slope= inte r cept). TnhlP 9· C:n ll' u lot; n n nfTnt<1 I D o<i, lu o< in o ..**~in~n•** n ntl Hn o 

### Ruminanl ( ppm ) I 

### log (pp m) Matrix R esidue from Re sidue from Re s idue from Re s idue from Diet Premi se' ToLal Re s idue Di ct Premi se' T o ta l R es idue kidney 0. 108 0.049 0. 157 0.062 0.010 0.072 li ver 0.196 0.072 0.268 0.091 0.0 15 0. 1 06 muscle 0.032 0.0 14 0.046 0.013 0.003 0.016 fat 0.879 0. 13 1 

### l. OIO 0.365 0.027 0.392 wh ole milk 0.276 0.0 15 0.291 

# -- -- -- skim milk 0.049 0.0 1 I 0.060 

# -- -- - - milk fat 2 

# -- -- 3.635 

# -- -- 

# -- 1 

### Since re s idue s following only premi se application are not available . l-IED used the average residues from the dcrmal pour- on magnitude of lhc r esid ue s tu dy adjus ted fo r a th eore ti cal I 0% dermal co nta c t with the premi se sp ray (sec T ab l e 6 for mo r e information). 2 

### Residue in milk fat 

### estimated as I 2.5x the" hole mil k re si due (0249374. M. Do heny. I4-Jun-I 999)



### P

age 9 of24

### Spinetoram and Spinosad Dietary Expo s ure and Ri s k Assessment 04 23657

Tabl e 10: S ummary o f Poultr y Feedin g St ud y an d Esti mated R esid u es in P ou ltry Com modi tie s. Feedin g Lev e l (ppm) 1 

### Projected Residue Com mod it y 0. 1 0.3 I 

### 5 Average combined Spinosy n A a nd D Residue (pp m ) (p pm )2

mu sc l e <0.003 < 0.003 <0 . 003 0.066 0.0 1 2 fat <0.03 0.04 0.14 1. 23 0. 12 7 liver <0.003 < 0.003 0.01 0 .09 0.009 egg <0.003 < 0.003 < 0.003 0.242 0.044 1 

### 0249374. M. Doheny. 24-Jun-1999 2 If 

### n :si du cs were > LOQ at th e I 

### ppm doing level. H ED used the se result s t o estima t e residues (estimated re sid ue = sp in osa d resid u e at tJ1c I 

### ppm dosin g l eve l + I 

### x 0.967 (0.967 is th e poultry dietary burden see Tabl e 7). If 

### re s idue s were < LOQ at th e I 

### ppm doing level, H ED u se d the results from the 

### 5 ppm doing level to estimate re sidues. Table 

### 11 : Total 

### R es idu es in Poultr y. Matrix Residue from Diet (oom) R esid ue from Demrnl / Pr em i se Aoo. ( oom) 1 

### Total Res idu e (ppm) mu sc le 0.012 0.08 1 0.093 fat 0. 1 27 0.346 0.473 liver 0.009 0.250 0.259 egg 0.044 0.090 0. 1 34 1 

### Sec 0374794 (T. 

### Bloem. 25 -M ar-2010: 47703001.der.doc) for th ese cst11n a tc s (average resi du es). 

## III . Wate r Data Drinkin g water res idu es were incorporate d directl y into the chronic dietary analy ses ( .. wate r. direct, all sources" and "w ater , indirect , a ll sources") an d were provided by th e Env ironmental Fat e and Effects D i vi s ion (E FED). EFE D generated the su rface and grou nd water esti mated drinkin g water concentrations (E D WCs) usin g the following models ( 041 5816, L. Liu , I 9-Feb**20 5~**  

## D325409 , L. 

## Liu , 14-May-2007): S urface Water Concentration Calculator (SWCC) and Sc ree nin g Concentration in Gr o und Water (SC I GROW). Tabl e 12 i s a summary of th e m ode led water co nc entrations. Ba sed on the se estimates, the chronic ana lysis assumed a wate r residue es timate o f 2 1. 7 ppb. The mod e l s and th e ir description are available at the E PA intern e t site: http: //www.epa.gov/ oppefed I/ mod e ls / water / . EF ED provid ed Pesti ci d e Root Z on e Model

- Groundwater ( P RZM-GW) EDWCs for s pin osad and s pinetoram u s ing only the prosed app li cation sce na rio s . Th e resu ltin g EDWCs were s ig n ificant l y low e r th an the su rfac e water EDWCs ge nerated u s i ng the sa me ap pli cati o n sce nari o and the S W CC . Based on this , HED conclude s that generation of PRZM-GW EDWC s usin g th e s pinosad/s pinetoram turf application scenario is unnec essa ry . Tab le 

### 12: E DW Cs for Spino s ad /S pin c t o ram (oo b ). Surface/G ro und (Mod e l) 

## I Acute 

## I Ch ro nic 

## I Long-term average soi n o sa d (turf aon licatio n scenario: 4 

### x 0.4 lb ai/ac re : RT I = 7 dav s ) 1 

### s ur face (SWCC) 

### I 25.0 

### I 2 1 .7 

### I 14.2 ! ground (SC I GROW) 

### I I.I 

### I I. I 

## I I. I 

### s nin etoram (turf and fir e ant m o und anolication; I x 

### 0.454 lb ai/ac r c) 1 

### su rface (SWCC) 

## I 8.6 

## I 5.9 

### I 3.8 ! g round (S C I GROW) 

### I 0 . 072 

### I 0.072 

## I 0.072 1 

### 041581 6. L. 

### Liu. 19-Feb-2015: 0325409. L . Liu. 14- May-2007



### Page 10 

### of24

### S pin e to r a m and S pin osa d Di e ta ry Ex p o s ure and Ri s k Asse ss m e nt 0 423657 

## IV. D EEM-FC IDTM 

## Pro g ram and Co nsumption Inform a tion C hroni c d ie ta ry ex p os ure assess me nt s we r e conducte d u s in g th e DEE M- FC ID (v er . 3 .1 6) , w hich incorp o rates 2 0 03

- 2 008 co nsumption data from U S DA ' s NHANE S / WWEIA. The data ar e ba se d o n the re p o rt e d co n s umpti o n o f more than 20, 000 indi v idu a ls over t wo no nc o n sec uti ve s urv ey d ays . F o od s " a s con s umed " (e. g. , appl e pi e) are linke d to EPA-d e fin e d foo d comm od iti e s ( e . g . , app l es , pee led fruit - c ooked ; fre s h or N/ S; b aked ; o r w heat flou r - c oo ked ; fres h or N/ S , baked ) u s ing publi c ly ava ilabl e recipe tran s lation fi le s d e vel o ped joint ly by US DA/A R S a nd EP A. Fo r c hroni c ex pos ure as s e ss m e nt , c on s umpti o n d ata are ave rag e d for the e ntire U .S . p o pul a ti o n a nd w ith i n populati o n s u bg ro up s . Base d o n a na lys i s of th e 2 00 3

- 20 08 WWE IA c on s umpti o n data , w hi c h too k in to account dietary pattern s and s urv e y re s pond e n ts , H E D co nclud e d th a t it is m os t appropri ate to r e p o rt ri s k fo r the fo ll ow in g po pulation s ub g ro up s : th e ge ne ral U.S . popul a tion, a ll infant s ( < 1 ye ar o ld) , c hildre n 1- 2, ch ildre n 3- 5 , ch il dren 6 -1 2 , yo uth 1 3 -1 9 , adult s 2 0 -4 9 , fe ma les 13

- 49 , and adult s 50

- 99 year s o ld. Fo r a c hro n ic di e tary ex pos ure assess me n t , an e s tim at e o f th e res idu e leve l in each fo od o r fo o dform (e . g., o ran ge or o ra nge jui ce) on th e foo d c omm o di ty r es idu e li s t is multipli e d by th e av e ra ge d a il y cons umpti o n es tim a t e fo r th a t fo od / food form to produ ce a re sidue int a ke es tim ate . Th e re s ultin g re s idu e intake es timate fo r eac h food/foo d fo rm i s s ummed w ith the re s idu e intake est imates for a ll o ther fo o d/ fo o d fo rm s o n th e commod i ty res idu e li s t to a rri ve a t th e to ta l average es tim a te d ex p o s ur e . Exp o s ure i s exp resse d in mg/kg b ody w e ig ht/d ay a nd as a p erce nt o f th e cP A D. T hi s proc e d ure i s pe r fonn e d for e ac h popu lat io n s ub g roup . 

## V. Toxico l ogica l Info r mation H E D co nc lud e d th at s pin osad a nd s pin etoram are to x ico log ica ll y e q u i vale nt and th at e xp os ures to these co mpound s s ho uld be c ombin e d (see ri s k asses sme nt D 33 l 74 l , P . Sh a h 

## e t al. , 2 0-S e p2 0 07). T he fo llo w in g i s a s umm a ry of th e diet ary e ndp o int s c hosen by H E D fo r di e tary ri s k assess me nt (see ri s k a ssess ment for rationa le; 0 3 31741 , P. S hah 

## e t al. , 20-Sep -2 007). B as ed o n t he t ox ico log ic al d ata b ases , th e ac ce p tabl e res idu e c he mi s try and en v ironm e nt a l fate data bases, and th e re s idue a ss umption s us e d in th e curre nt ass e ss ment , HED c o nclud e d th at th e FQP A safe t y facto r (S F ) may be red uc e d to l x . T able 

### 13: S umm ar y of Toxicologica l D o s e s and E ndp oi nt s for S pin e t o ram and S pino sa d for Use in Di e tary Human H ea lth Ri s k Asse ss m e nt' . E

x pos ure/ Scen a ri o P o int o f U ncert aint 

# Rm . P A D. LO C fo r R isk Stud y and To xico l o g ica l Eff ec ts De par ture FQPA S F Ass es s m e nt Acu t e Di etary A dose and e ndp o int of concern attributab l e t

o a s in g l e do se wa s no t ob served . ( /\II 

### po p ul ati on s ) C hr o n ic to xi city dog (s pi netoram); LOA EL C hro ni c Di etary INOAE L = 2.49 

### U FA = ! Ox 

### c Rm = 0.0249 

### m g/k g/day = 5.36/ 5 . 83 m g/k g/da y ( m a l

es/f e m ales ) based U

F

H = lOx o n arteriti s and necro s is o f th e art e rial wall s of (A ll P o pul ation s) m g/kg/ d ay FQPA S F = I x c P A D = 0. 024 9 

### m g/kg/ da y t he e pi di dy mi dc s in ma l es an d th e th ym u s. t l wro i d . la rvn x . and ur i nary b ladder in females Cance r (ora l. C lass ificati o n: .. N o t like l y to be C arc in oge nic to I 

### l uma ns.. de rmal. in halation) 0/\EL = no - obs e rved adverse- e ffe ct l eve l. L O/\E L = l o w est- o bse rve d a dve rse-eff e ct l ev el. UF = un cert ain t y fac to r. UFA = ex t ra po l ati o n from a n im al lo human ( int ra s pcc i cs ) . lJ F11 = po t e nti al vari ation in se ns iti vity a mon g m e mb e rs o f th e hum a n p o pulati o n ( int e rs pecie s). FQP/\ SF = FQP/\ S afet y Fa cto r. PAD = po pulati o n- ad j u sted dose (a = a cute . c = chro nic ). RID = 

### r efe r e nce dos e (a = acute . 

### c =c hr o ni c). MO E= m ar

g in o f e xp os ure. L OC = leve l of c o n cern (r = re s i de nt ial, o = occ upati o na l ) . NIA = 

### no t app licable. Page 11 of 2 4

### Spinetoram and Spinosad Dietary Exposure and Risk Assessment 04 23657 

## VI. Re s u l ts/Di sc uss ion The chronic dietary analysis resulted in expos ure es tim a te s of :5 64% cPAD (children 1- 2 years old were the mo s t hi g hl y expose d population subgroup); therefore , chronic exposure to spinosad/spinetoram does not exceed H ED ' s level of concern. Tab le 14 is a summary of the results of the chronic ana l ys i s. Ta b le 14: 

### S ummary o f C hr o ni c Dietary (food and water) Ex po s ur e a nd Ri s k for S pin osa d /S 11inetoram. cPAD (mg/k g/day) Chronic Population Sub g roup Expos ure ( mg/ kg/day) %c PAD ge neral U.S. Population 0.005029 20 all In fants (< I ye ar old) 0.007054 28 c hildren 1 -2 

### yea r s o ld 0.0 1 586 1 64 children 3-5 yea rs old 0.010909 44 children 6- 1 2 years o l d 0.0249 0.006734 27 you th 1 3 -1 9 years o ld 0.00 3924 1 6 adu lt s 20-49 years old 0.004353 1 8 adult s 50+ years old 0.003889 1 6 female s 1 3-49 years o ld 0.003967 1 6 

## VII. C haracte ri za tion of Inputs/ Outputs Th e chro nic analysis i s refined in that it used average field trial residues , experimental processing factors , and refined li vestock residue estimates. Further refinement is possible through the incorporation of percent crop treated estim ates and PDP monitoring data. 

## VIII. Co nclusion s HED concluded that spinosad and sp inetoram are toxicologically equivalent (see risk assessment 

## 0 33 1741 , P . S hah 

## et al. , 20-Se p-2007) ; therefore, exposures to these compounds we re comb in ed. As a resul t of the proposed application of spi no sad/s pinetoram to coffee and the proposed updates to several crop group/ subgroup commodity definitions , a chronic dietary r isk assessment was co ndu cted using D EEM-FC ID (ver . 3. 16 ) w hi ch in corporates food consumption data from N H ANES /WWEIA (2003-2008). Acute and cancer analyses were not cond ucted as toxicological effects attributable to a s in g le dose were not id e ntified and sp in e toram and spinosad are classified as n o t likel y to be carcinogens (cancer risk assessment is not required) . The chron ic a na lys i s assumed I 00% crop tr eate d , average field-trial residues or tolerance -l evel residues for crop commodities, average residues form the livestock feeding study, s pinosad residue estimate s for fi sh/s hellfi s h (residues of sp inetoram in fish/ shellfish are expected to be in s ig nifi cant ), experimental process in g factor s whe n available, and mode led drinking water estimates. The resulting chronic exposure estimates do not exceed HED' s leve l of conce rn ( :'.564% c hronic pop ul a tion -adju s ted dose (cPAD); children 1-2 years old were the most highl y expose d subpopu lation). Attach ment I: DEEM-FC ID TM c hroni c residue file. Attachment 2: DEEM-FCIOTM chronic exposure estimates. Page 1 2 of24

### Spi net o ram and S pin osad Di e ta ry Expos ure and Ri s k Assess me nt 

## Attachment 1: D EE M-FCIDTM chronic res idue file.

i'"! le:ia:n,. : C : \U5<' rs\ tblO"m\Doci.:ments\..,o.d:\spinosao\coCfee\l:0003C . ROB ChPmi cal : spir.oqad HfD(ChronicJ : . 0249 mg/kg bw/day NOEL(Chronicl : 2 . 4Q mg/f:q bw/day Rl:l(ACULf l : 0 me: r:g b1o· day NOEL: ."<c;.ite) : 0 mg/l:g b·.;/day DaLe creaLed/last**~odtfi,.d :**  04-30

- 2015/06 : 24 : 31**Progr~m** ver . 3 . 16 , 03-08

- d Co:nment : lOx interspecies ; 10;: !ntraspecies ; lx FOPA Sf E:PA Crop Def Res Code Grp Co:-.-.od i;: y**r~amC'** <ppm 0'.01050000 1A3 01ft1C500 1 L'>.B 0101052000 IA 0101052001 1,-, 0101053000 lA 0101053001 lA 010!067000 iAB 0101078000 li\8 0101078001 1A£l**0!0:0790-~** 1A3 0101084000 lAB**01~':00000** 

### :AB ')101168000 1Ai3 0101190000 l.'IB 01012500C'ft l.P.3 0101251000 lAB 010:2s:oo· :AB 0101314000 li\B 0101316000 U\0 0101:}:'700" JAB 0101331000 lAB 0101388000 t;..s 0101015000 

### :er' 0103015001 JCD 0103Cl7000 !CC 0103082000 !CD 0103082001 lCD 010313<1000 lCD 0103166000 !CD 010'.?16b001 !CD 01c31r;1000 ten 0103296000 lC 0103291001 

### :c**010320~"** " lC 01032?8001 

### :c 0101299000 IC 010329'1001 

### :c 0103300000 lC 0103300001 lC 0103360000 lCD 0103366001 JCD 010337:000 lC[. Beet , garden , roots P..t:?e:. ,**QGt?:"der~ ,**  r:):;r_s-bQbyfood aect , sug<<r Beet ,**SJga~-babyfood** Beet , sugar , :-classes Beet , sugar , molasscs-babyfood E!:Jrdocl: Carro;: Carrot-babyfood Ca:-:-0! , juice C:cler i1H' cr.ico:-y , root:> Ginseng , d::-ied l!orserd<.lish Parsl"Y , curn i p rooted Parsnip**Parsn~p-baoyfooo** Radi:sh , roots Rddish , Oricntdl , roots**Rut.a~.Jr;a** Salsify , root:; curnip , roots Arrowro..it , flout Arrowroot , flour-baby'ood 1\r:ic?\**~Y.c ,**  J"et :J!:5dlem CdSSiJVU C<.issavd-habytoo<i DashePn , ::arm Ginge: ::;:.nger-o.:ibyCood Gingc-r , dried Potato , chips Pota•o , =ry tgtdnules/ flokcsl i.'ot;:ito , dry ((]ra n ules/ flake,;)

- b Potato , flour Pocato , f lour-babytood Pot;:ito , tuber , •,;/peel ?ocato , tucer , w/pee.-baoyfood Potato , • ubcr , w/o peel**Po~ato ,**  tuber , w/o P"<'l-babyloo:l Sweet p.')•ato Sweet potato-babyfood Tan:e:- , corm 0 . 032000 0 . 032000 0 . 100000 0 . 100000 0 . 750000 0 . 750000

" · 100000 0 . 017000 0 . 017000 0 . 0:1000 0 . 100000 

## o . 100000 0 . 100000 0 . 100000 0 . 100000 0 . 100000 0 . 100000 0 . 017000 0 . 017000 ( . 100000 0 . 100000 (' . 100000 0 . 100000 0 . 100000

. :00000 0 . 100000 0 . 100000 0 . 100000 0 . 100000

. 100000 0 . 100000 0 . 005000 0 . 005000 0 . 005000 0 . 005000 

## o . oo:iooc 0 . 005000 0 . 005001' 0 . 005000 

### o . oo5oor 0 . 100000 0 . 100000 

## o . 100000 

### Page 1 3 of24 i\dj . factors Comment**~** l**~** 1 . 000 1 . 000 1 . 000 1 . 000 l . 000 1.000 1 . 000 1 . 000 1 . 000 l . 000 1. 000 

### : . ooo 1 . 000 1 . 000 ; . 000 I . 000 

### : . ooo 1 . 000 1 . 000 1 . 000 1 . 000 

## : . coo 1. 000 1 . 000 

## : . ooo l. 000 : . 000 1. 000 1 . 000 

## o. ooo 1 . 000 : . 000 6 . 500 6 . 500 6 . 500 6 . 500 : . 000 1 . 000 1 . 000 L . 000 1 . 000 1.000 1 . 000 1 . 000 1 . 000 1 . 000 : . 000 I . 000 : . 000 1 . 000 1 . 000 l . 000 1. ODO 

### : . ooo 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 l . 000 1 . 000 1 . Q('(j 1 . 000 l. OJ 1 . 000 1 . 000 l. Ol 

## : . ooo LOO : . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1. 000 1 . 000 1 . 000 1 . 000 : . 000 1 . 000 1 . 000 l . 000 1 . 000 

## : . ooo 042 3657

### Sp in etorarn and Spino s ad Di e tary Exposure and Ri sk As sess ment 0103381000 lC O 0103406000 1CD 0103407000 IC!J 0200051000 2 0'.!00101000 2 0200140000 2 0200315000 2**02003!~0'10** 2 0200332000 2 0301165000 3A 03011€500! 3A 0301237000 3A 030:237"01 3A 030 123 9000 3A 0301239001 31\ 0101339000 3A 0302103000 3B 0302199000 '.!9 030223<1000 ]fl 0302339500 3B 0401005000 4A 04010113000 4A 0401104000 !,J\ 0401:33000 4A 0401134000 4A orn1l3eooo 

### rn 0401150000 4A 0401204000 4l\ 040:205000 4A 040124BOOO 4A 0401313000 4A 040:355000 4A 0401355001 41\ 0402076000 !,B 0402085000 413 04 02085001 4B 0402086000 4B 0 402081000 48 0402152000 48 0402322000 4i3 0402367000 48 05010(1000 5;, 0501061001 51\ 050106 

### ono 5A 0501064000 5A 050106'1000 SA 0501071000 SA 0501072000 5A 0501083000 5A 05011%000 SA 0502063000 SB 0502070000 513 050211"/000 SB 0502194000 53 050222 1000 53 Turmer le Yam , :rue Yam bedn BeeL , garden , tops Chicory , tcps Dasheen , leaves Radish , top s Radish ,**or:en~a: ,**  tops Salsify , tops Garlic , bulb Garlic , bulb-bdby!ood Onion , bulb Onion , bu:b-babyfood Onion , bulb , dried Onion , bulb , oded-bubyfood ShallC\t . ou.t;, Chive , fresh leaves**Lee~:** Oniori , grerr. Shallot ,**f~~ sh**  leavPs**P.~aranth ,**  leuty Aruquld**Chrys~nthemu- .** **qarl~nd** Cress , garder. Cress , upland Dand"'l ion ,**l""~ves** Endive**Let~uce .**  heao Lettuce , led ( ?a rs ley , I caves Radicchio Spin.i ·t, Spin.ich-babyfood Ca::-doon Celery Co::lery-babyfood ce,ery , juice Celtucc fennel , Flor-•nce Rhubarb 

### s.... iss chard Brocrc.11 Broccoli

- baby food Broccoli. Clii:iese**Bruss~.~ sprou~~**  Cabbage catbago , Chinese, napa Cabbage , Chinese ,**mus~ard** Caul i llowc::- Kohl r.:ibi !Jroccoli raab Cat:o ... ge , Ch:n,,se , bol: choy Collards Kale**Musta~d** greens 0 . 100000 0 . 100000 

### o . 100000 10 . 000000 10.000000 10 . 000000 10 . 00000 0 10 . 000000 l0 . 000000 0 . 100000 0 . 100000 

## o . 100000 o . 100000 0 . 100000 0 . 100000 U

. 1000 0**000000** 4 . 000000**.** 000000 4 . 000000 3 . 961000

, . 961000 3 . 961000 3 . 961000 .J . 961000 ) . 961000 3 . 961000 0 . 796000 1 . 498000 3 . 961000 0 . 796000 3 . 961000 3 . 961000 1 . 026000 1 . 026000 1 . 026000 1 . 026000 1 . 026000 l . 026000 : . 026000 l. 026000 0 . 3:3000 0 . 313000 0 . 313000 0 . 081000 0 . 081000 0 . 08}000 0 . 313000 0 . 313000 0 . 081000 4 . 000000 4 . 000000 4 . 000000 4 . 000000 .: . 000000 

### Pag e 14 of24 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 

## : . ooo I . 000 1 . 000 1. 000 1. 000 

## : . coo 1 . 000 1 . 000 9 . 000 9 . 000 : . 000 l . 000 

## : . ooo 1 . 000 1 . 000 : . ooo 1 . 000 

## : . ooo 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1.0 00 l . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 l . 000 1 . 000 1. 000 1 . 000 1 . 000 l . 000 1 . 000 1 . 000 1 . 000 1 . 000 t . 000 1 . 000 1 . 000 : . ooo 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 

## : . ooo l . 000 1.00 0 

## : . ooo 1 . 000 

## : . ooo 1 . 000 1.00 0 : . 000 1 . 000 1 . 000 1 . 000 l. 000 

### : . ooo 1 . 000 1.000 1 . 000 1 . 000 i . 000 1 . 000 l.000 1 . 000 1 . 000 1 . 000 l . 000 ! . 000 1 . 000 1 . 000 J . 000 1 . 00.., l . 000 l .**o~o** 1. 000 : . 000 1 . 000 1 . 000 1.000 1 . 000 1. 000 1 . 000 1 . 000 1 . 000 1 . 000 1.000 l . OrlC 1 . 000 1 . 000 l . OOv j . 000 1 . 000 1 . 000 1.000 1 . 000 

### 04 23657

### S pin eto ram and Sp in osad 

### Di etary Ex p os ure a nd 

### Ri s k Assess m e nt 050-110000 5B 0502:1R<l000 SB 0600 1 ·1100" 6 o600J4 riooo 6 Of»lO'·I <lOl c 0600350000 G 0600 1 5000 1 6 0601043000 6A ::>601043001 f,P, 

### Oco1: ooo tA 060:3t,9500 GAB OGO:O''lOCC 68 060:033000 (,}! 06020 l/000 iB 0602:'55000 68**060~:'5500 1**  FB**060225~000** uR 0603030000 6C" 06oJ0320oo 

### .,c 06030.l 40CO GC**060:103~000** bC**06030~6ooo** <ic 06030J•JOOO bC 060J03qooo**~c** 0603040000 6C 0603 4 000 EC 06030!,2000 6C 0 6030 '<6000 tC 06030'•!!00 l oC**0~030'l<l000** GC Rape gr•_<:ns ·1·ur·nip , ryreea!i Se>;t><><in , :<'ed Soyoean , soy milk Soyllc<in , soy rr il •:-babyfood or ir. Soybean , oi l**Soyb~an ,**  oi: -b atiyfood 13,...l)n ,**~n~p ,**  !-),Jcculent Bl!.in , s1 ..Jp ,**su~c:ilent-baby~ood** Pea, ec... b.1." poodcd, su '"'cclent Soybean , veqetablc**s~a~ ,**  br dO,**succule~t Bt~.;.Jn** **,** cowpea , succulcn\:**B~an ,** **11~a, succu:e~c**  Pi?a ,**~ucrt:.lcnt** Pea ,**~ucculent-baby~oc** J PPd , pig''On , su-culPnt**B~ar1 ,**  bldck ,**sP~d** Bnun , br ad , seed

Bean , kidney , seed Bean , limrl , seed !$ear ., mung , seed Bean , navy ,**se~d** Bnan , pink ,**S9~ct** Bean , pin to , sPed**Chic ~pe;;** **,** seed Chickpea , seed-hilbyfood Ct.ic>:pe" · flour**6031~~000** 6C**Gu~r .**  send 0603102001 6C**G~<lr,** sePd-oabytood**OGO~- ~~oo**  t:.c 0603256000 6C**060~-~bOOl** bC 0603258000 bC 060::: 1 4eooo**~c 0603'.~~**  BOOl 6C 080137 ·1000 HA Ot<0:37$000 '<A 080 1 37500 1 fJA 080131ti000 ;.. 0801376001**~i\** 

### oso 13nooo 

### a;, OB0:3°1700l H •i**080137~000** 8A 080i37"001**~1i** 080137QOOO llA OB0214tl0 00 813C 0802:'70000 SB 080:2"'000:**~(' 0•0'~71000** **~B** 0802:>7100: RR Leut i l , :;<'ed Pt?ZI , dry PeJ, dry-babyfooc ?ed ,**pig eo~** **.** seed Seiybedr. , t!our Soybean , flour-habyfood Tomotillo TO:'!ldLo Toma Lo-b;;.byfood TOmdtO , f'i(.tS':.e**TO~dto ,**  paste-babytood**TOm.:l~O ,**  puree To="ato , pll ree-b ;1hyfood Tomilto, dded**To~aro ,**  dried-bJOyfood Tomdto , juice -c-aLo , Tree t:qqplanL Pepper , bell ?epper, bt>ll-bJbyfoo: Pepper , b•!ll , dried FPpper , bell ,**rtried-bJby~ood** !, , 000000 4 . 000000 0 . 040000 0 . 040000 

### o . o•o**~a** 0 . 040000 C\ . 040 10 0 . 066000 0 . 066000 0 . 087000 0 . 066000**04000~** 0 . 040000 0 . 0400C 0 . 040000 0 . 040000 0 , 040000 0 . 040000 0 . 040' 0 0 . 040000 0 . 0·10 "0 0 . 04 0000 0 . 040000 0 . 040000 0 . 040000 0 . 040000 0 . 040000

" . 040000 0 . 040000 0 . 040000 0 . 040000 0 , 040000**0~0000** 0 . 040000 0 . 0400\lO 0 . 040000 !'l . 040(, )0 0 . 040000 0 . 053000 0 , 053000 0 . 053000 0 . 053000 0 . 053000 0 . 053000 0 . 053000 0 . 053000 0 . 053000 0 . 053000 0 . 0:,3000 0 . 054000 

### o . 1!0000 0 . 054000 0 . 054000 0 . 054000 0 . 054000 

### Page 15 of24 1 . 000 t . 000 1 . 000 1 . 000 l . OOC 1.000 1 . 000 l , 000 l . 000 1 . 000 1 . 000 l . OOC J . 000 1 . 000 1.000 1 . 000 1 . 000 1 . 000 : , 000 1 . 000 ; . 000 1 . 000 1 . 000 1 . 000 1 . 000 : . 000 J , 000 1 . 000 LOOO : . ooo 1.000 : . 000 1 . 000 1 . 000 1 . 000 J . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 l . 000 1 . 000 l . 000 1 . 000 1 . 000 1 . 000 1 . 000 l , 000 I . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 l . 000 1 . JOO 1. 000

, . '.)00 1 . 00 0 1 . 000 l.OOC : . 000 l . 000 1. 000 1 . 000 1 . 000 l , 000 1 . 000 1 . 000 1 . 000 J , 000 :! . 100**.** 100 0 . 100 0 . 700 :.1 . JOO 14 . 300 O . JOO l . 000 1 . 000 1. 000 1 . 000 l , 000 1 . 000 1 . 000 1 . 00 0 1 . 000 J . 000 1 . 000 1 . 000 1 . 000 l . OOC 1 . 000 l . 000 1. 000 1 . 000 1. 000 1 . 000 l. 000 I . 000 J , 000 l . 000 : . 000 1.000 1. 000 l. 00 0 ! . 000 1 . 000 

### 04 2365 7

### Spinetoram and Spi no sad Dietary Exposu re and Ri sk Assessment 080:'272000 BBC**080~~72001** BBC 0802273000 BBC 090107500(' 9A 0901187000 9f\ 090 l 3 9 9000 Q}',**0901~00000** 9b 0902021000 98 0902088000 QB 0902102000 9B 090213500C QB 0902308000 9B 0902309000 QB 0902356000 98 09021' 6001 QB 0902357000 'lB 0902357001 QB 1001:06001" JOA 1001107000 lOA Pepper , nonbell Pepper ,**non~ll-babyfood** Pepper , nonbcll , drled Canta:uupe Honeyde"' melon**Wdter~elon** WJterme'on , juice B,dsam pear "hayotr ,**~ruH** Chines<> waxgourd CucumbP.r Pum p kin Pumpkin , seed Squash , suer.mer Squash , surnmnr-babyfood $quasr1 , • .. dntc t Squash , wintrr-babyfood Citron Citrus hybrids 1001108000 IOA Cicrus, oi_ 1001240000 lOA Orange 1001241000 lOA 10012H001 lOA 1001242000 lOA 100:369000 lOh 1001370000 l O A 100:>! Q7000 !OB 1002199000 lOB 100:'200000 JOB 1002200001 lOB 1002201000 JOB 100220600C !OB**100~207000** !OB 1002207001 108 1003180000 lOC 1001181000 lOC 1003307000 JOC 1100007000 11 1100008000 i: 1100008001 11 1100009000 1: 1100009001 11 11000:0000 11 1100010001 11 110001i000 11 1100011001 11 1100129000 11 :!001'3500 

### a 1100210000 11 l'.Ol.:66000 1! 1100/.66001 11 1100267000 11 Jl0026BODD 11 11D026800J l1 11DD310000 11 Oranqe , juice Orange , iulce-babyfood Or<1nge , peel T<Jnger1n" Tongeri11e , juice Ku:::qu<1' Lemon Le:-:on , juice Lemon , 1uice-b<1byfood Lemon , peel L1me Lime . juice Lime , uice

- babyfood Grape;ruit**Grapet~ui~ .**  juice Pu>Tc.elo Apple , fruit with p<'el Apple , peelcu truit Apple , peeled tniiL-babyfood Apple , dried Apple , dried-h«byfood Apple , Ju.:.ce Apple , juice-oabyfood 1\pple , "auce Apple , sauce-babyfood Crabapple Loquat Pear P<.:ar

- babyfood Pear . dried Peor , uice Pear , juice-bdbyfood Ou inc<' 0 . 110000 0 . 110000 0 . 110000 0 . 09!,000 0 . 004000 0 . 09t.OOO 0 . 00400C 0 . 046000 0 . 0281'\00**0~6000** 0 . 046000 0 . 020000 0 . 028000 0 . 0:'8000 0 . 028000 0 . 020000 O . D28000**O~!'lOOO** 0 . 085000 3 . 000000 0 . 095000 0 . 085000 O . D85000 0 . 085000 O . D85000 0 . 085000 0 . 095000 0 . 066000 0 . 068000 D . 0680DO 0 . 068000 

### o . oc. 000 0 . 06tJOOO 0 . 068000 0 . 05.,000 0 . 0!>7000 0 . 057000 0 . 0?8000 0 . 0::!8000 0 . 020000 D . 0:>8000 0 . 026000 0 . O::!!lOOO 0 . 0:?8000**0~8000** 

## o . o::eooo 0 . 0::!8000 0 . 053000 0 . 029000 0 . 0:::0000 0 . 02'1000 0 . 020000 0 . 02<1000 0 . 0?.'lOOO**0~~000** 

### Page 16of24 1 . 000 1 . 000 1 . 000 

## : . ooo 1 . 000 ! . ODO 1 . 000 I . ODO 1 . 000 1 . 000 : . 000 I . 000 l.000 l . DOO 1 . 000 l . 000 l . 000 I . ODO l.000 1.000 1 . 000 1 . 000 : . 000 1 . 000 l . 000 1 . 000 1 . 000 J . OOD 1 . 000 

## : . ooo l . 000 1 . 000 1 . 000 1 . 000 1 . 000 l . 000 l . ODO 1 . 000 1 . 000 1 . 000 I. 000 I. 000 0 . 100 0 . !CO 1 . 000 l . OOD 0 . 100 1 . 000 l . 000 0 . 100 0 . 100 1 . 000 1 . 000 0 . 100 c . 1Do 1.000 0 . 100 I . OOD 1. 000 1 . 000 1 . 000 8 . 00D B . 000 0 . 100 0 . JOO l. 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 I . 000 6 . 250 1 . 000 l . 000

• . 000 1 . 000 1 . 000 : . 000 1 . 00' 1 . 000 l . OOD l . OOD l . 000 I . DDD 1 . 000 1 . 000 1 . 000 J . ODO 1 . 000 l . 000 1 . 000 1 . 000 l . OC" 1. 000 l . OOD 1 . 000 1 . 000 l . 000 l . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 J . 000 I.ODO 1 . 000 1 . 000 i . ODO 

### 0423657

### Spinetoram and Spinosad Di e tary Exposure and Ri s k A ssess m e nt 1201090000 12A 1:?01090001 ::?A 1:01091000 l:?A 1:'0109:00: i:?A 1:0201:000 l.!8 : O:?Ol'.'001 I 28 l.'.?C2CJ:lCCC ::'B ::?D.'.?011000 l'.!B 12C.'.?Cl4C'Ol l:'B ! _02230000 128 l.'.?0.'.?.'.?60000 !:'B 1:02260001 l.'.?O :202:6:000 l.. 9 l.!02261001 12B ::O.'.?:?G:>OOO 123 1::!0226::!001 l.'.?B l.'.?0329!l000 12C l.'.?0328500: l.'.?C l'.'03.'.?86000 12C 1:0328t,001 12C l.'.?03287000 l.'.?C 1:'03.'.?87001 

### ::c 

### i:o3:aaooo i:::c 1:'0328(100: '.!C**130105~000** lJA :<Ol05('l00**l~A** 130 I 05600! Dl\ 1301058000 l3h 

### i3o::oeooo l"IA PO 13:!0000 llA l'.10:320001 l,A UOl321000 ?311 1 1 01321001 13A**11020~7CCO** DB 1302C57CC1 !1P. ;**~<02** l3b000 lJB J1C":J7CCO 139 l.lC214 40CO 11f3 

### uo::1.;ooo i·•3 110:101000 138 l ·:P2.'.?7COC' l 1C l !0417'>000 110**u~417t>OOC** 13D 130417600: l 3D l'l04 J7 QOOC l3J 1304 ! 95000 l 3D 1307 lJOCCC 13G l "\07130001 1 JG l3C"1!1l00C i3G 1Jo'.)71J2CCO l )G i"<07P.'.?001 !JG :**3C73~QOOO** 13G 1307**35~lOO1** l 3G :307360000 13G Cherry Ct.erry-babyfooo rhcrry , ju ... l'"f"' Cherry , juice-babyfood Apricot Apricot-baby food Apric1 t ,**dri~c** Apdcot , juice l•pricot , ju i ce-b.,byfood Nectar in" Peach-baby food Peach , drio:.o Peach , dried-babyfood Peach , Juice Peach ,**juic~-babyfood** P:um ?lum-babyfood Plum , p!"une , fresh Plum , prunr , :r,.sh-brtbyfooc: ['lu::i , prune , driPd ?lum , prune , dr:ed-oabyoood r1um , prune , juice Pl um , prur.'J ,**juic ~-babyfood**  Blackberry B**ackb~rry ,** **uic~** Blackb0rry , iuic0-babytood BoysenOl'.!rry ;,.oganbcrry Raspb<•r ry-b,Jbyfood RaspbPrry , juice R.,spbcrry , juice-babyfood Blueb.,rry Blueberry

- brtbyrocd Curran ·**,~** J.r::ant , dried ElderbPrry G"">Seb ..rry Huckleberry**xu:~rry** Grape Grape , juirf' Grape , iuice-babytood**~rape ,**  •,.•ine and sherry :<iwifruit , tuay Crdnberry Cranbcrry-b<iby!'ood Cranberry , dried Cranbe-ry ,**1uic~** Cranbetiy , juice-tJabytood Stra..-t-><>rry St ra w bPrry

- bi-lbytood SlrowO. rry , }uice 1107360001 i3G Strawberry , juicc-babylood 0 . 068000 0 . 068000 0 . 068000 0 . 068000**O<l~OOO** 

### o . oq:woo O . OQ2000 0 . 002000**O!l~OOO** 0 . 073000 O. OQ2000 0 . 092000**0~2000** 0 . C92000**O<l~OOO** 0 . 0<l200C 0 . 041000 O . O:'COOO 0 . 04100C 

### o . oaoco 0 . 041COO C . 041000 0 . 041000 0 . 041000 1. 000000 l . 

### cooooo l . 000000 1 . 000000 : . 000000 1 . 000000 l . OOOOCC l . OCOOOO 1 . 

### ooucoo 0 . 500000 

### c . srooco 0 . 500000 0 . 500000 0 . 500000 0 . 50000v 0 . 500000 C . O:>COOC 0 . 150000 0 . 150000 0 . 150000 0 . 1!>0000 0 . 020000 0 . 2!l2000 

### o

_

::s:wco 0 . .'.?52000**2'~000** 0 . 252000 

### o . ..**'~ooo** 0 . 252000 0 , 252000 C . 25200C 

### Page 1 7 o f24 1 . 000 1 . 000 1 . 500 I . 500 i . 000 1 . 000 6 . 000 l . ODO 1 . 000 1 . 000 l . COO 

### l . coo 7 . 000 7 . 000 l . 000 l . COC 1 . 000 1 . 000 1. 000 

### ; . coo 1 . 300 1 . 300 1 ..

100 1 .**~00** 1 . 000 1 . 000 1 . 000 

### : . ooo 1 . 000 1 . 000 1 . 0CO 1. 000 

### : . coo 1 . 000 l . COO 1 . 000 l . CCO l.000 J 

### . coo : . 000 l . OOC l.000 1.200 1 . :>OO l.000 1 . 000 1 . 000 l . 1'110 1. 000**100** 1. 100 1 . 000 l 

### . oco 1 . 000 1 . 000 1 . 000 l . OOv l . 000 l . C01; l . OOC 

### : . coo 1. 000 l . OCC 1 . 000 1. 000 1 . 000 1. 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 I . 000 1 . 000 : . 000 1 . 000 i . 000 1 . 000 1. ODO l . 000 J . 000 1 . 000 1 . 000 l . 000 1 . 000 l . OOC 1 . 000 l . OOC J . 000 ; . DOC 1. 000 

### ; . oco 1 . 000 1 . 000 1 . 000 1. 000 1 . 0CC 1 . 000 l . CCO 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 

### ::. . occ J . 000 

### : . ooc 1.000 1. 000 

### 0423657

### Sp inetoram and Spinosad Dietary Exposure and Risk Assessment 1400003000 14 1400003001 14 1400004000 14 1400004001 14 1400059000 14**:~001\68000** :4 1400001000 14 H000<:.2000 H 1400155000 14 1400156001 14 H00185000 H 1400 .. 13000 14 1400269000 H 1400278000 14 1400282000 14 H00391000 lt, 15000:?5000 15 1500025001 15 i500026000 15 1500026001 15**15000~7000** 15 1500065000 15 150006600 15 1500120000 15 1500120001 15 1500121000 15 :500121001 15 1500122000 15 15001:?3000 15 1500123001 15 1500124000 15 15001::!400. 15 1500125000 15 1500125001 15 1500126000 15 1500127000 

### :s 1500127001 15 1500-2600\J 15 150023 1 000 15 1500-32000 15 1500?32001 lS 1500233000 15 1500233001 15 1500323000 15 150032300 l 15 1500324000 15 1500324001 15 1500325000 15 1500325001 15 1500326000 15 1500326001 15 1500328000 15 150"'329000 15 150031,4000 15 1500345000 ;5 Almond Almond

- oabyfood Almond , o ii Almono , oil-babyfood Br azil nut ButtPr:tut cashew Che::;Lni;t Hazelnut Ha::e..1..nut.. , oil llicl:ory nut Macadar..ia nut Pecan Pinc nut ?istdchio walnut Barley , poarled barley Barley , pearled barley-babyfood Barley , flour Barley , flour-babytocd Barley , brar. B

uckwheat Buckwheat , flou: Corn , fit!ld , flour Corr. , fit>ld , flour-bilbyfooo Corn , :ield ,**m~al** Corr. , field , m!.'a.

- bdbyfood Con1 , fi<'ld , bran Corn , fi<'la , starch Corn , fiAld , starch-babyiood Corn , :1rld , syrup Corn , fi1;ld , sytup-babyfood Corn . fir>ld , oil Corn , field , oil

- bdbytood Corn , pop**Co~n ,** **sw'?~·** Corn , sweet-babyfood Mil.et , grain Oat , bran oa· ' flo ... r Oat , f l our-babyfood Oat , gro,·s/rolled OdtS Oi>t , groats/rolled oats-babyfood Rice , · ... ·h ... te**Ric~ ,**  white

- babyfood Ric" , brown Rice , brown-babyfood Ric•: , flour**Ric~ .**  flour-babyfood Rice , braa RicP , brdn

- baby!ood Rye , grain Rye , flour Sorghum , grain Sorqh.i.-:- , y rup \; . !00000 0 . 100000 0 . 100000 0 . 100000 0 . 100000 0 . !00000 0 . 100000 0 . 100000 0 . 100000 

## o . 100000 0 . 100000 O . lOOuOO 0 . 100000 0 . 100000 0 . 100000 

## o . :00000 0 . 652000 0 . 652000 0 . 652000**65~000** 0 . 65:?000 1 . 500000 1 . 500000 0 . 510000 0 . 5 : 0000 0 . 5 1 0000 0 . 510000 0 . 510000 0 . 510000 0 . 510000 0 . 510000 0 . 510000 0 . 510000 0 . 510000 0 . 510000 0 . 040000 0 . 040000 1 . 500000 0 . 495000 "l . 495000 0 . 4 95000 

## o . 4951'00 0 . 495000 0 .**66~** )00 0 . 664000 0 . 664000 0 . 664000**664000** 0 . 664000 v . 664000 0 . 664000 1 . 500000 1.**~00000** 1 . 500000 1 . 500000 

### Page 18 of24 1 . 000 1 . 000 1 . 000 l . 000 1 . 000 l . 000 l . 000 1 . 000 1.000 1 . 000 1.000 l . 000 1 . 000 1 . 000 1. 000 1 . 000 l . 000 

### t 

## . ooo 1 . 000 1 . 000 1 . 000 l . 000 1 . 000 0 . 220

. 220 0 . 260

" · ::'.6C 1 . 000 0 . 010 0 . 010 0 . 010 0 . 010**~00** 1.200 1 . 000 l . 000 1.000 1 . 

### oco 1 . 000 1 . 000 1.000 1 . 000 l.000 l . 000 1 . 000

• . 000 1 . 000

. . 000 1.000 1 . 000 ! . 000 1 . 000 1.000 l.000 1 . 000 l . 

### oou l . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 : . 000 1 . 000 1 . 000 l . OOC l.000 1 . 000 1 . 000 1 . 000 1 . 000 i.000 1 . 000 1.000 1 . 000 1 . 000 

## : . ooo 1 . 000 1 . 000 1.000 1 . 000 1 . 000 1 . 000 

## : . ooo 1 . 000 1. 000 1.000 1 . 000 : . 000 1 . 000 1 . 000 1 . 000 1 . 000 ! . 000 1 . 000 l . COO 1. 000 1 . 000 1.000 1 . 000 : . 000 1 . 000 l . 000 1 . 000 1 . 000 

### 0423657

### Spine toram and S pino sad Di etary Expos ure and Ri sk As sess ment t<00381000 15 l**~ll0381001** 15**1500~01000** 15 1L00401001 15 1S00402000 15**1500~02001** 15 1500403000 10> 1500·104000 15**150040~000** 15 lt!00002000 18 l c.0102aooo l 9F-. l •0102600: :9A 1Q01029000 19A l •01029001 !9A :•0::02500 i9;, 1 <101119000 l 9A 1 ;G111soo: :9A 1 

### oo 1144 000 1 9F-. lqt'll8400C !9A : •O::B4001 19A l '•01202000 19A 1**~Q?** 2:'.:000A : 9A l<l0\220001 l9A 1 '•0 12 4 90 0 0 l 9A • •01249001 19l\ l 'lOl 334000 l 9JI. l •02105000 :q13 i qo2:osoo1 19B 1"02119000 196 P0:>::900: :99 l "0214 3000 1 98**1·0~27400C** 19B H0'.'27400: ;93 1"02354000 198 1 •"23514001 198 ::001: 63000 20;, 2001310000 2CA 200131900! 20A**"!'!"itical~ ,**  f.!.(ur Tdticdlc , tlo1.r-babyfocd**h'h~at ,**  Qrni.n ·r1heat ,**c;ra~n-babyfood Whea~** **.** flour Wheat , t lour-baby food**Whea~ ,**  qerrn Wheat , bran W-ld rice Alfalfa , seed Basil , fresh lnaves B"sil , fresh la<>ves

- babyfood Basil , dried laavcs H.;sil. dd<?d lP**>V<?s-baby~ood** Ch!ve , dried leaves Ci la1't ro , lea ·:•·s Cilantr., , leavas-oabyfood Dillwead Herbs , th'?r H'?rbs , other-bJnyfood Lemar.qr ass Mc1rjo:-ar-**~arjcram-babyfood** ?arsl,...y , dr i'.!d _eavP.:> Pa!"s:cy , drir!d**l~aves-babyfood** S;1vory Cinnamon-baby load C·" t lcu.U' r ,**S~,_..d** CorSandPr ,**s~ed-bdoyfood** :.li 11. saac**Pep~~r ,** **h:ac~** ana**wh1c~** Pepper , bldck and white-babytocd SpLces , nth<?r Sric<?s ,**oth<?r-haby~ood** flax seed , oil Rapes,..,..d , oil Rapeseod , oil-babytood 2001336000 2CA Sesame , seed '.!00133600 l :?OA Ses;ome , seed-b<Jby foon :C00:337000 20A _001337001**~OA** :'00::!330000 208 2002330001 203 2002364000 208 ::002365000 208 200:'365001 :OR 2003114001 '.!OC :'.:00312tl000 20C :OO'l::BOOl 20C**2100:>~8000** ..,, 3:00044000 31**31~004400:** 3: 1100045000 31 jl('0046000 3: Sesarr.c> , oil Sesame ,**oi! brl~yfcod**  Sattlower , oil Safflow••r , oil-b;ibyfood**Sun:low~r .** **sie~o Sunflowt~r** **,** oil Sunflower , oil-babyiood Coconut , oil-b<Jbyfooa Cottonseed , oil Cottonseed , i 1-baby ! ood Mushroo:- floef , m<'ilt Be'?[ , :-.cat - oabyfood Beef , meat , drled 8"ef ,**~** ... at :'.>yproducr s l . 500000 1 . 500000 0 . 551000 o . :.51000 0 . 551000 

## c . 55:000 0 . 551000 0 . 551000 1 . 500000 

## o . 150000 l . :>00000 : . 200000 13 . 920000 13 . 

### c.:wooo 13 . 920000 8 . 000000 e . 000000 1 3 . 920000 13 . 920000 13 . 920000 11 . G20000 13 . 920000 lJ . 920000 lJ . 0::!0000 13 . Q20000 11 . 920000 0 . 180000 0 . 180000 0 . ltlOOOO 0 . 180000 0.180000 0 . 020000 0 . 020000 0 . 180000 0 . 180000 0 . 020000 0 . 020000 0 . 020000 D . 070000 0 . 020000 0 . 020000 C . 020000**0~0000 0~0000**  0 . 020000 0 . 020000 0 . 020000 0 . 100000 0 . 040000**0~0000** 0 . 020000 0 . 046000 0 . 04 6000 0 . 046000 1. 010000 

### Page 19 of24 1 . 000 l.000 l. 000 

### : . coo 0 . 320 0 . 320**5~0** 1 . 000 1 . 000 1.000 1 . 000 1 . 000 1 . 000 1 . 000 ; . 000 1 . ODO 1.000 l. 000 1 . 000 

## : . coo l . 000 J . 000 ! . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 : . ooo 1 . 000 1 . 000 : . 000 1 . 000 1 . 000 : . 000 1 . 000 1 . 000 1 . 000 1 . 000 

### : . coo 1. 000 1 . 000 i . 000 1 . 000 1.000 1 . 000 1 . 000 

## : . ooo l. 000 1 . 000 1 . 000 1 . 920 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 : . 000 l. 

### ooc : . coo 1 . 000 1 . 000 l. 000 1 . 000 : . 000 1 . 

## ooc : . ooo 1 . 00C l.000 1 . 000 1 . 000 : . 000 1 . 000 1 . 000 

### : . coo 1. ODO 1 . 000 

## : . coo 1. 000 I . Oil(' l. 000 1 . 000 

## : . coo l. 000 1 . 000 

## : . ooo 1 . 000 1 . 000 1 . 000 1. 000 : . 000 1 . 000 1 . 000 ! . 000 1 . 000 l . 000 1 . 000 1 . 000 1 . 000 l . 000 1 . 00' 1 . 000 1.000 LOCO 1 . 000 1 . 000 

### 0423657

### Sp in eto ram and S pin osa d Dietary Ex po s ure and Ri s k A ssess ment 3100046001 31 3100041000 31 3:00047001 3'. 3100048000 31 '310004 '+000 31 3100049001 31 3200169000 32 3200170000 32 3200171000 32 

### noo1nooo 32 .J200173000 32 3300189000 33 34002<!0000 34 3400290001 34 3400291000 34 3400292000 34 3400292001 34 3400293000 34 3400293001 34 3400294000 34 'l400295000 34 3500339000 35 350033'<001 35 3500340000 35 3500341000 35 J500341001 35 3500342000 3!> 350031.3000 35 36002:'2000 36 3600222001 36 36002:'3)00 3€. 3600223001 36 3600224000 36 360022t.001 36 3600225001 36 JB00221000 3B 3900312000 JG 4000093000 40**~000093001** ·10 t.000094000 t,O 400009$000 40 •00009500: 40 4000096000 40 4000096001 40 t.0000"'7000 40 4000097001 40 5000382000 50 5000392001 50 !>000383000 !>O 5000393001 50 5000394000 50 5000384001 50 5000395000 50 5000385001 50 $000386000 50 Beet , meat**byp~oducts-baby(ood** Beer , Ult 3ecf , fat

- b.>bytood Beef , kidney Beef , liver Beef , liver-b.:iby:ood Goat , meat Goat ,**~eat** byproduc·s Goat , tat Goat , l:idne1• Goa:: , liver lloi:-se , meat Pork ,**m~at Por~** **.** mcat-baby:ood Pork , skin Pork ,**~ea:** byprodu=ts Pork . meat byproducts-babyfood Pork , !at Pork ,**fat b~by:ood**  Po::-k , kidney Pork , l1\'er Sheep , ::-1eac Sheep , meat-brlbyfood Sheep , meat byproducts Sheep , fat Sheep ,**fat-b~byfooa** Sh""P · l:idn<'y Sheep , liver**~'.ill: ,**  fot Mill: , fat

- baby food/infanL for m u Milk, nonfa' solids Mill: , nonfat soiids-baby food/in Milk , water Mil I: , wat:er-o.,bytood/ i :'l rant fo:-m Mill: , sugar (lactosu)-baby food/ Meat , gdme Rabb1L , meat Chic}:en , mcc:;L Chicken,**mea~-baoytood** Chickrm , liver Chi cl:1>n ,**r..e~l** byproducts Chicl:en , meat**byproduccs-o.,by~oo** ChiCkl"ll , fat**Chick~n .**  fat-babyrood Chicken , skl n Chicl:cn , sl:in-b<1byfood Tcrl:ey , mear Turl:,,y , meat-babyfood Tcrkey ,**liv~t** 7ui:-i:,.y , livPr-babyfood Turkey , meat byproducLs Turl:t•y , meat**byproduc~s-bdby!ood** Turkry , fat Turk1>y , fat-babyfood Turkey , sl:ir. 1.010000 1 . 010000 1 . 010000 0 . 157000 0 . '.?68000 0 . 268000 0 . 046000 1 . 010000 l . 010000 0 . 157000 0 . 268000 0 . 046000 O

. Oi6000 0 . 016000 0 . 392000 0 . 39'.?000 0 . 39'.!000 0 . 39'.?000 0 . 392000 0 . 07'.?000 0 . 106000 0 . 046000 0 . 04GOOO : . 0100 10 1. 010000 1 . 010000 0 . 15'1000 0 . 268000 3 . 63500) 3 . 635000 0 . 291000 0 . 291000 0 . 060000 0 . 060000 0 . 2<11000 0 . 046000**0~6000** 0 . 093000

" . 09300() 0 . '.?59000 0 . 473000 0 . 473000 0 . 473000 0 . 03000 0 . 473000 0 . 473000 0 . 093000 0 . 093000 0 . 259000**~59000** 0 . 413000 0 . 03000 0 . 473000 0 . 413000 

### o . 03000 

### Page 20 of24 1 . 000 1.000 

### 1. ... oo 1 . 000 1.000 1.0 10 1.000 1 . vOO 1 . 000 1. 000 : .000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 

### : . ooo 1 . 000 l . 000 1 . 000 1 . 000 1 . 000 1.000 1 . 001'1 

## : . ooo 1 . 000 1 . 00" 1.000 1 . 000 1 . 000 1.000 1 . 000 l . 000 1 . 000 1 . 000 l . 000 1 . 000 1.000 1 . 000 1 . 000 1.000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1.000 1 . 000 1 . 000 1. 000 

## : . ooo 1 . 000 1.000 1 . 000 l . 000 l . 000 1 . 00" 1 . 000 1 . ')00 1 . 000 1 . 000 1." 0 1 . 000 

### 1 . noo 1 . 000 1. 000 : . 000 1 . 000 1 . 000 ; . 000 1 . 000 1 . 000 1 . 000 1. 000 : . 000 1 . 000 1 . 000 ; . 000 1 . 000 1 . 000 1 . 000 1 . 000 l . 000 l 

## . coo 1 . 000 l . 000 1 . 000 1 . 000 1.000 1 . 000 1.000 1. 000 1 . 000 l . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1.000 1 . 000 1 . 000 1.000 : . 000 

## 04 23657

### Spinetoram and Spinosad Dietary Expos ure and Risk Assess m ent 5000386001 50 6000301000 60**6000•(~000** 

### lO 6000303000 60 C0003t 4000 60 6000305000 60 7 

### ooo i.t 5000 ., 

### o 10001"500: 70 70001•16000 70**1000:~600:** 1C 700010000 '10 000 l 0001 7C 8000157000 RO 

## eooo:i;eooo RO dOOOl bOCOO 80 8000161000 80 •OOOlt>- 00 ::lO 8€01000000 ti6 A**"60~0** 10(' '%3 Q500000500 0 3500'10t000 0 C.500001500 0 Q500006DOO 0 .<5COOlEOCO 0 (150001'l000 0 "'50001G500 0 95000::0000 0 c.5000:::000 0 05000"3000 0 '-5000:J001 0 '.f5000:4000 0 "500024001 0**~·500054000** 0 950001i0000 0 •500073000 0 050007!o000 0**~sooonooo** 

### o**15000~3'.lOOO** O '1$00109000 0 1500110000 0 9500111000 0 <1500l!'OO: 0 050011:000 0 •500113000 0 •50011 ·1000 0 C.500115000 0 '.fSOOi!nOOO 0 9500141000 0 

## •soo:s:ooo o Q500153000 0**3500:5~000** 0 'l5001770CC O •5 00118000 0 450018'3000 0 4500!B.>001 0 7ur;:ey , skin

- oaoyfcod Poultry ,**othe~ ,**  meat Poul::.ry , other , _iver Poul tr y , ocher , meat byproducts**Poul~ry ,**  ether , fa::. Poultry , ocner , skin E<1() , Wh<.>1" <.gq , whole-baby1ood F:qq ,**·~ hite** **E~q ,**  wh1·c (solidsl -baby t cod E:og , yoll: Egq , J<..l ·:-babytooc Fish

- t1eshwa:e1 finfish**Fi:<h tre~hwater**  finfish , tat::' ra Fish-saltwater t!nfish , ocher Fish -sh ellfish , crustacean Fish-shel-f ish ,**~ollusc** Wa t.,.r , direct , al l sources A

cai b erry Ag.JVC A:ia!'.'anth , qrain Art1cnok•' , glollc J\::.;paragus At"moya Avocado 8drr::oo , shco:.s 13,,n,,md Banana

- baby food Bariario , dt i ed Ban,na , dr!ed

- oabyfood B"lgiu:- <'ndive Breadfruit Ci<**·~::s** Cisriistel Carnb Chcrimoya Co ·oa be.sn, chocota:.t? Cocoa be.Jr, , powdrr coconuc ,**~eat** coconut , meat-babyfood Coconut , d!'.'ied Coronut , mill: Coconu:: , oil Coffee , roasted**bea~** Coffc,, , 1 r.stant DatP Fcijoa F'io Fig , ari"'d Grape , leaves**Gr;~ ,**  Ldjsin Guava Gu.wa

- baby food 0 . 473000 0 . 0Q3000**25~000** 0 . 473000 0 . 0]000 0 . 473 000 0 . 134000 0 . 134000 0 . 1J400C 0 . 134000 0 . 134000**13~000** l . 2· 1 000C**~~0000** 1 . 240000 t . 240000 1 . 240000 0 . 02!700 L . 021700 0 . 020000 l. 500000 0 . 020000 l . 000000 0 . 300000**0~0000** 0 . 300000 0 . 300 000

" . 02000 O . Otlt.000 <' . 004001) 0 . 084000 O . Oe4000 0 . 020000 0 . 020000 

## o . nooro 0 . 300 000 0 . 0200"" 0 . 300000 0 . 020000 0 . 020000 0 . 100000 0 . 100000 

### o . 100000 0 . 10001'" 0 . 100000 0 . 040000 0 . 040000 0 . iOOOOO 0 . 300000 0 . :00000 0 . 100000 0 . 150000 0 . 150000 0 . 300000 0 . 300000 

### Page 2 1 of24 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 00 0 1 . 000 : . 000 1 . 000 1 . 000 J . 000 1.000 1. ODO 1 . 000 1. 000 l . 000 J . 000 J . 000 1 . 000 l . 000 l . 000 1 . 000 

## : . ooo 1. 000 1 . 000 J . 000 1 . 000 1 . 000 1 . 000 1 . 000 J . 'lOO 3 . QOO l . 000**~** . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 t . 000 1 . 000 :: . 100 1 . 000 J . 000 1 . 000 1 . 000 l . 000 1 . 000 1 . 000 : . '100 1. 000

. 000 l . ODO l . 000 1 . 000 : . 000 1 . 000 l . 000 1 . 000 1.000 1 . 000 : . 000 1 . 000 : . 000 1 . 000 J . 000 1 . 000 1 . 000 1.000 1 . 000 l . 000 1 . 000 1 . 000 I . 000 l . 000 1. 000 l . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 J . 000 : . 000 1 . 000 J . 000 l . 000 1 . 000 : . 000 1 . 000 l . 000 1. 000 ). 000 l . 000 l . 000 1 . 000 1 . 000 1 . 000 l . C:!O 1.000 1 . 000 1 . 000 1. 000 J . 000 1 . 000 l . 000 l . UOO 1 . 000 1 . 000 

## 0423657

### Spinetoram and Spi no sad Di e ta ry Expo s ure and Ri s k Asses s ment 9500186000 0 9500186001 0 9500188000 0 950 193000 0 9500209000 0 9:,00211000 0 9500212000 0 9500214000 0**9500~15000** 0 9500215001 0 9501)216000 0 9500217000 0 950021700: 0 9500218000 0 9500:>19000 0 9:,00235000 0 9500236000 0 950024300" 0 9500244000 0**950024~001** 0 9500245000 0**9500~45001** 0 9500246000 0 9500247000 0 9500::52000 

### o**9500~52001** 0 9500253000 0 9500253001 0**9500~54000** 0 9500263000 0 9500264000 0 9500265000 0 9500275000 0 951)0276000 0 9500277000 0 9500279000 0 9500279001 0 9500280000 0 9500281000 0 9500281001 0 9500:83000 0 9500284000 0 9500299000 0 9500306000 0 9500311000 0 9500333000 0 9500335000 0 950033:,001 0 9500346000 0 9500351000 0 9500352000 0 9500353000 0 9500158000 0 9500361000 0 950C162000 0 Honey Honey-baby food Hop Jac;.:ru.t Longan Lychee Lychee ,**d~ied** Marney <>pple Mdngo Mango-baby food**~dngo ,**  :Jriea Mango , j uicc**~.mgo ,**  · u ice-baby food Maple , sugar Mllple syrtJp Oli •:e Olive , oil ?alm heart , leaves Palm , oil**?al~ .**  oil

- babylccd Papaya !',;ipaya-babyfood Papaya , dried Papaya , juic1• Passi ntr:lit PassiontruiL-babyfood**?dssionfruit ~**  juice Passiontruit , JUice-babyfood Pawpaw Peanut Peanut , buttnr Pear.ut, oil Peppermint Pepper:-int , oil Persimmon Pineapple Pineapple

- oabytood Pineapple , dried P1neapp;e ,**ju1~e** Pineapple , juice -iMbyfood Plan;:a1n f'lantairi , dr ;,,d**Pcmegrana~"'** Psyllium , seed Ouinoa , grairi Sapote , Mamey Seawee<l Sea,.eed-babylocd Sours op Spanish**lim~** Spearmint Spearmint , o'.l Starfrult Sugar <ipple Suga!"C(.lt.e , st:qcH· 0 . 020000 0 . 0:>0000 :!2 . 000000

0 . 020000 0 . 300000 0 . 300000 0 . 300000 0 . 020000 0 . 300000 0 . 300000 0 . 300000 0 . 300000 0 . 300000 0 . 02UOOO 0 . 020000 0 . 02)000 0 . 020000 0 . 0:)000 0 . 020000 0 . 020000 0 . 300000 0 . 300000 O . JOOOOO 0 . 30000C 0 . 30t1(1QO 0 . 300000 0 . 300000 0 . 300000**0~0000** 0 . 040.JOO 0 . 040000 

### o . ...**~** l\OO 3 . 500000 3 . 500000 0 . 020000**0~0000** 0 . 040000 0 . 040000 0 J\40000 0 . 01.0000 O . Oti·:OOO 0 . 094000 0 . 300000 0 . 020000 0 . 020000 C . 300000 0 . 020000 0 . 020000 0 . 300000 0 . 300000 3 . 500000 3 . 500000 0 . 300000 0 . 300000 0 . 020000 

### P

age 22 of24 1 . 000 1 . 000 l . 000 1 . 000 1 . 000 l . 000 l. 850 1 . 000 1 . 000 1. 000 : . 000 1 . 000 l . 000 1 . 000 l.000 l . CO" 1.000 1 . 000 l . 000 1 . 000 

## : . ooo l . 000**80~** 1 . 500 I . OOL J . 000 1 . 000 : . 000 l . 000 l . OOC l. 690 1 

### . oar 1.000 l . 000 1.000 1 . 000 1 . 000 5 . 000 : . 700 1 . 700 1 . 000 3 . 900 1 . 000 i . 000 1 . 000 

## : .ooo 1 . 000 : . 000 J . 000 l. ODO 1.000 1 . 000



## . .coo l . 000 

### ; . oco 1.000 l . 000 l . 000 J . 000 1 . 000 1 . 000 1 . 000 1.000 1 . 000 1.000 l . 000 l . 000 1.000 1 . 000 l.000 l . COO 1 . 000 1 . 000 1.000 J . ODO ; . 000 l . OOC 

## : . coo I . 000 ! . COO 1 . 000 l. 000 i . 000 J . 000 :. . 000 1 . 000 

## : . oco 1 . 000 l . 000 l . 000 l. 000 1 . 000 1 . 000 

## : . oco l . 000 1 . 000 1 . 000 l. 000 J . 000 l. 000

• . OOl l . 000**000** I . 000 l . 000 l . 000 l. 000



## . . oco 1 . ODO 1 . 000 

### 0423657

### Spine toram and Spi n osad Dictarv Ex p os ure and Ri s k Asse ss ment 042 3657 '>50036200: 0 $.;gart; Jne , sigor -b <tOYLOOd 0 . 020000 : . 000 1 . 000 •500363000 0 Sugil rcaru" , molasses 0 . 020000 1 . 000 1.000 '1500363001 0 Suga rc .. ne , moldsses-b"byfood C' . 020000 

### : . coo l. 000 >•-036!!000 0 -a:'.la!"ind u . 020000 1 . 000 

## : . ooo ""00372COO 0 Tea , diied 0 . 020000 

## : . ooo 1 . 000 G5003?3000 0**T~a ,**  in;:;tar.t 0 . 020000 1 . 000 1 . 000 ''.>00390000 0 '1!neg,;ir**0~0000** i . 000 1 . DOC <15CC397000 0**wa~er** chestnut 0 . 020000 1 . 000 l . 000 •'.>00398000 0**~**.**.-1c:~::--cr''SS 000000**  

### : . ooo 1.000



### Page 23 of24

### Spinetoram and Sp ino sad Dietary Expos ure and Risk Assessment 

## Attachment 2: D EEM-F C JD TM chronic expo s ure es timates. US £PA JEEM-FCID Chronic analysis fer S?H: 1 1SAD Ver . 3 . 16, 03 -08-d 1-:HA!';:;s**200~ -2** **00~** - - d<Jy Residue file**n~m<• :**  C : \Users\tbloem\Oocuments\work\spinosad\co[Lee\ll0003C . R08 Adjustmem: f.vtor 1':? KOT 'JS"d . Ana lys is Dvte 04-30-2015/06 : 25 : 40 Residue file dated :**04-30-2015/06 ~C** **~l** Re!"rence dose (RfD , Chronic) •**02~~** ng/Y.q bw/day COM:-lEHT 1 : lOx interspecies ; lOx intraspecics ; lx FQ?A S!'" Totvl exposur<? by pop1;J.,tion l!ubgrot;p

Population Subgroup Tor .. 1 US Population Hispanic Non-Hisp-White Non-llisp-Bldci: Non-Hisp-Othcr :-lcrsl ng Infants Non ·Nursing Intants fcmdle 13• PREG Chiloren i-6 Children 7-12 Male 13-JQ l"cmale lJ-19/NP Male 20• Female 20•/HP Sen l ors 55, Jl.ll Infants female 13-50 Chlldre:. 1-2 Children 3-5 Childre:> 6-12 Youth 13-19 Adul·s 20-49 Adults 50-99 Fen dle 13-49 rr.g/kq body wt/day

0 . 005029**005~88** 0 . 004062 0 . 004625 0 . 006207 0 . 003346 0 . 009710 0 . 004118 o . 01:Jb6 0 . 006311, 0 . 01'4181 o . 003C82 O . OO!o413 0 .**003'l~S** 0 . 0037S3 0 . 007054 0 . 003%0 0 . 015861 0 . 010909 0 . 006734 0 . 003<!24 0 .**0043~3** 0 . 003889 0 . 003067



### Page 24 of24**Pe.rc~nt** of Rf<i



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. 1%

. 3• 15 . 9\ 63 . 7• 43 . 8%**~7 0\** 

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### 0 423657