STRUCTURE ACTIVITY TEAM REPORT 03/02/04

CASE NUMBER: **P04-0346/0347**

RELATED CASES

CONCLUSIONS/DISCUSSIONS

TYPE OF CONCERN: HEALTH ECOTOX

LEVEL OF CONCERN 1-2 3
1 1

KEYWORDS: IRR-MM,L DEVEL

MUTA AQUATOX

SUMMARY OF ASSESSMENT

FATE: with 100% <1000 and 100% <500 solid with mp 60 to 130 C (M), however, (n=2 with n=1 included) was reported to have a mp = 48 C (DSC) in the PMN log Kow = 6.8 for (n=1) (EPI) log Kow = 12 for (n=2) (EPI) S at n=1 with = 0.020 to 0.030 mg/L at 25 C (P) S at n=2 with < 0.001 mg/L at 25 C or negligible VP at 25C (mm) < 1.0E-6(E) H < 1.0E-8(E) log Koc = 7.9 and 13 for (EPI) log fish BCF for (n=1) = 4.6 (EPI) log fish BCF for (n=2) = 0.500 (EPI) log fish (carp-whole fish) 60-d BCF at (n=1&2) = 1.8 at SS and 0.019 mg/L (FT,M) log fish (carp-whole fish) 60-d BCF at (n=1&2) = 2.0 at SS and 0.001875 mg/L (FT,M) ready biodegradation test data for n=1&2 with were: 0% in 28 d via BOD and 0% in 28 d via HPLC, thus, not readily biodegradable at 100 mg/L, 30 mg ss/L DWT, 25 C with MITI(I) test (OECD301C) POTW removal (%) = 90 via sorption;. Time for complete ultimate aerobic biodegradation >= months PBT Potential: =P2B3T2

=P2B1T1
=P2B1T1 Sorption to soils/sediments = v.strong *CEB FATE: Migration to ground water = negligibleHEALTH: Absorption of low molecular weight fraction is expected to be poor all routes (pchem) absorption of nil all routes based on physical/chemical properties;

Concern for irritation to mucous membranes, lung, and GI tract based on submitted test data; concern for mutagenicity based on submitted test data; concern for developmental toxicity based on ;

*CEB HEALTH: =Low moderate concern (Dermal, inhalation, ingestion) *CEB HEALTH: =low concern (No exposures needed for human health risk assessment)

Test data for mixture (n=1 and n=2) with : (-) Salmonella with and without activation; (+) for chromosome aberrations in CHL cells with and without activation; (-) E. coli with and without activation; rat 28-day oral NOEL = 200 mg/kg, GI tract irritation at 1000 mg/kg

ECOTOX: Predicted (P) and measured (M) toxicity values in mg/L (ppm) for are: fish 96-h LC50 = * P daphnid 48-h LC50 = * P green algal 96-h EC50 = * P fish 30-d ChV = 0.008 P fish 90-d ChV = 0.003 P daphnid ChV = 0.006 P algal ChV = 0.020 or * P Predictions are based on SARs for ; SAR chemical class = ; log Kow = 6.8 (EPI); solid with mp = 48 C (M) and S = 0.020 to 0.030 mg/L at 25 C (P); pH7; effective concentrations based on 100% active ingredients and mean measured concentrations; hardness <150.0 mg/L as ; and TOC <2.0 mg/L; high concern for chronic toxicity;
assessment factor = 10.0 concern concentration = 0.001 mg/L (ppm) *CEB ECOTOX: All releases to water with CC = 1 ppb

Predicted (P) and measured (M) toxicity values in mg/L (ppm) for

are: fish 96-h LC50 = * P fish (KF) 96-h LC50 = 29.0 M SR12h,N FLAG daphnid 48-h LC50 = * Pgreen algal 96-h EC50 = * P fish 30-d ChV = * P fish 90-d ChV = * P daphnid ChV = * P algal ChV = * P FLAG: LC50>S=0.020 to 0.030 mg/L at 25 C or less; Predictions are based on SARs for; SAR chemical class = or greater; ; log Kow => 12 (EPI); solid with mp => 48 C (M) and S < 0.001 mg/L at 25 C (P); pH7; effective concentrations based on 100% active ingredients and mean measured concentrations; hardness <150.0 mg/L as ; and TOC <2.0 mg/L; low concern for toxicity;
assessment factor = 10.0 concern concentration = *
*CEB ECOTOX: No releases to water

SAT Co-chair: Leonard Keifer 564-8916