National Cancer Institute
 

U.S. Department 

of HealtH anD 

HUman ServiceS 

national institutes 

of Health 

caBIG

® Integration Hub 


Clinical Trials Workflow Integration 

The caBIG

® Integration Hub enables tools and applications in the caBIG® Clinical Trials Suite to 

interface seamlessly with one another, as well as with other compatible systems and applications. 

This software supports integrated clinical trials workflows and offers users flexible interoperability. 

For instance, users may use it through the Cancer Center Hub Client application—an integral part 

of the Integration Hub—to enable the exchange of data from in-house clinical source systems 

such as clinical chemistry laboratory systems, or with clinical trials systems such as Clinical Data 

Management Systems (CDMS). Users may view laboratory data in transit between these systems 

and select subsets to send to the CDMS, or select out-of-range lab results for notifying the caBIG® 

Adverse Events Reporting System (caAERS) in the Lab Viewer application. 

The caBIG

® Integration Hub facilitates use of the National Cancer Institute’s services-based enterprise 

architecture. When users select study personnel and participating organizations in any of the caBIG® 

Clinical Trials Suite applications, they are selecting from a curated global list using NCI Enterprise 

Services. Through this process, errors and inconsistencies are eliminated, and standards are enforced. 

The caBIG

® Integration Hub is Enterprise Service Bus (ESB)-compliant with the Java Business 

Integration (JBI) specification and is integrated with caGrid. 

The caBIG

® Integration Hub is used to create integrated business workflows to link existing 

applications and databases. The caBIG

® Clinical Trials Suite is one example of how this tool is used 

in clinical trials management, as all caBIG

® Clinical Trials Suite applications leverage the caBIG® 

Integration Hub to transfer information between the applications. 

caBIG

® Integration Hub – caBIG® Clinical Trials Suite Integration 

Categories of Use 

Biospecimens Data Sharing Imaging Proteomics 

Clinical Trials Genome Annotation Microarrays Translational Research 

Management Infrastructure Pathways Vocabularies 

Data Analysis 

& Statistical Tools 
 

 

caBIG® Integration Hub 

Clinical Trials Workflow Integration 

CTMS Knowledge Center https://cabig-kc.nci.nih.gov/CTMS/KC 

Features 

•		Leverages	open-source	standards	based	on	Apache	Servicemix	to	facilitate	

adherence to standards, vendor independence, and collaboration 

•	 Integrates	Clinical	Connector	for	generic	integration	to	CDMS	vendors	such	as	

Oracle Clinical and OpenClinica 

•	 Provides	multiple	connectivity	options	by	supporting	integration	standards	such	

as Web services, JEE, JMS, FTP, CSV files, and e-mail 

•	 Provides	an	extensible	and	flexible	ESB-based	architecture	using	the	JBI	

framework; new JBI components can be plugged in to extend and complement 

existing features 

•	 Simplifies	integration	of	multiple	disparate	applications

•	 Supports	multiple	eXtended	Markup	Language	(XML)	file	formats	including	

Biomedical Research Integrated Domain Group (BRIDG) and Health Level Seven (HL7) 

•	 Supports	integration	with	caGrid	and	non-caGrid	environments

•	 Supports	synchronous	and	asynchronous	processing

•	 Provides	reliable	messaging,	reliable	transactions,	and	high	availability,	as	well	

as message transformation and notification capabilities 

•	 Meets	enterprise-class	performance	and	reliability	requirements

•	 Provides	a	configurable	mechanism	for	quickly	and	easily	adding	and	modifying	

integration scenarios using configuration files 

Primary Workspace Clinical Trials Management Systems (CTMS) 

https://cabig.nci.nih.gov/workspaces/CTMS/ 

Tool Overview Page https://cabig.nci.nih.gov/tools/LabIntegrationHub 

Other caBIG® 

Clinical Trials Suite 

Components 

•		caBIG® Adverse Event 

Reporting System (caAERS) 

•		caBIG® Central Clinical 

Participant Registry (C3PR) 

•		caBIG® Clinical Connector 

•		caBIG® Lab Viewer 

•		caBIG® Patient Study 

Calendar (PSC) 

Technical Overview 

•	Database	(MySQL)

•	Application	container	

(Tomcat) 

•	 ESB	Container	(Apache		

Servicemix) 

•	 caGrid	1.3Services

CTMS Forums https://cabig-kc.nci.nih.gov/CTMS/forums 

Resources 

CTMS LISTSERVS https://list.nih.gov/archives/cabig_ctms_cond_sig.html 

https://list.nih.gov/archives/cabig_ctms-l.html 

caBIG® Tool Inventory https://cabig.nci.nih.gov/inventory 

caBIG® Support Service Providers https://cabig.nci.nih.gov/esn/service_providers 

niH publication no. 10-7532 NCI Center for Bioinformatics ncicb@pop.nci.nih.gov Updated December 2009 Applications Support 

caBIG® Product Representative caBIGproductRep@nih.gov 

caBIG

® Integration Hub