National Cancer Institute
 

U.S. Department 

of HealtH anD 

HUman ServiceS 

national institutes 

of Health 

caBIG

® Central Clinical 

Participant Registry (C3PR) 

Study Participant Registry 

For decades, clinical study sites have used paper and Excel® spreadsheets to track registration 

information when enrolling patients into clinical trials. Not only does this make the data prone 

to error and difficult to review, but it also promotes inconsistency and fragmentation, and makes 

larger-scale, multi-center trials unmanageable. 

The caBIG® Central Clinical Participant Registry (C3PR) is an open-source, Web-based system that 

enables efficient and streamlined registration of participants into clinical trials. It can be used by 

an individual site or by a multi-institutional organization with geographically dispersed sites. C3PR 

helps organize and standardize templates for patient registration. Once the informed consent 

information, inclusion/exclusion criteria, stratification categories, and treatment arms and regimens 

are entered, reviewed, and approved, the study can be activated for patient accrual. C3PR provides 

a user-friendly patient registration wizard which walks the study coordinator through the process of 

enrolling, registering, and randomizing patients. The system tracks screening failures and enrollment 

statistics and can be configured to alert study personnel when accrual thresholds are met. 

C3PR 2.0 has been enhanced to leverage the National Cancer Institute’s services-based enterprise 

architecture. When users select study personnel and participating organizations in C3PR, they are 

selecting from a curated global list. Through this process, errors and inconsistencies are eliminated, 

and standards are enforced. 

C3PR Interface 

Categories of Use 

Biospecimens Data Sharing Imaging Proteomics 

Clinical Trials Genome Annotation Microarrays Translational Research 

Management Infrastructure Pathways Vocabularies 

Data Analysis 

& Statistical Tools 
 

 

 

caBIG® Central Clinical 

Participant Registry (C3PR) 

Study Participant Registry 

Features 

•	 Features	a	user-friendly	dashboard	interface

•	 Features	a	workflow-based	data	entry	wizard

•	 Tracks	clinical	trial	milestones	(site	initiation,	informed	consent,	eligibility	

criteria, stratification, and treatment assignment) 

•	 Features	an	import	option	for	importing	study	templates

•	 Includes	a	companion	protocol	feature	for	tracking	patients	on	multiple	studies

•	 Supports	protocol	amendments,	backdated	registrations,	and	re-consent	

•	 Generates	e-mail	and	dashboard	user	notifications	for	study	events

•	 Enables	error-free	study	personnel	and	organization	management	through	

the NCI Enterprise “Person” and “Organization” services 

•	 Generates	parameterized	study	and	registration	reports

•	 Enables	NCI	Cancer	Centers	Branch	“Summary	3”	Reporting

•	 Facilitates	integration	and	interoperability	with	other	clinical	systems	in	the	

caBIG® Clinical Trials Suite 

Technical 

Specifications 

•	Database	(PostgreSQL	

or Oracle) 

•	Application	container		

(Tomcat) 

•	 caGrid	(optional,	needed		

for multi-site interactions 

and deployment as part 

of the caBIG® Clinical 

Trials Suite) 

Other caBIG® 

Clinical Trials Suite 

Components 

•		caBIG® Adverse Event 

Reporting System (caAERS) 

•		caBIG® Clinical Connector 

•		caBIG® Integration Hub 

•		caBIG®	Lab	Viewer

•		caBIG® Patient Study 

Calendar (PSC) 

Resources 

Tool Overview Page https://cabig.nci.nih.gov/tools/c3pr 

Clinical Trials Management Systems (CTMS) Primary Workspace https://cabig.nci.nih.gov/workspaces/CTMS/ 

CTMS Knowledge Center https://cabig-kc.nci.nih.gov/CTMS/KC 

CTMS Forums https://cabig-kc.nci.nih.gov/CTMS/forums 

CTMS LISTSERVS https://list.nih.gov/archives/cabig_ctms_cond_sig.html 

https://list.nih.gov/archives/cabig_ctms-l.html 

caBIG® Tool Inventory https://cabig.nci.nih.gov/inventory 

caBIG® Support Service Providers https://cabig.nci.nih.gov/esn/service_providers 

NCI Center for Bioinformatics ncicb@pop.nci.nih.gov Applications Support 

niH publication no. 10-7433 caBIG® Product Representative caBIGproductRep@nih.gov Updated December 2009 

caBIG

® Central Clinical Participant Registry (C3PR)