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  <xs:element name="NetSalesTargetsMember" id="pgnx_NetSalesTargetsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="ChangesInUnrealizedGainsOrLossesForPeriodIncludedInEarningsOrChangesInNetAssetsForLiabilitiesHeldAtEndOfReportingPeriod" id="pgnx_ChangesInUnrealizedGainsOrLossesForPeriodIncludedInEarningsOrChangesInNetAssetsForLiabilitiesHeldAtEndOfReportingPeriod" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" />
  <xs:element name="MilestoneRevenueFromFuji" id="pgnx_MilestoneRevenueFromFuji" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" />
  <xs:element name="MilestoneRevenueFromSalix" id="pgnx_MilestoneRevenueFromSalix" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" />
  <xs:element name="ExpectedFutureMilestoneReceivable" id="pgnx_ExpectedFutureMilestoneReceivable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" />
  <xs:element name="CommonStockOfferingPrice" id="pgnx_CommonStockOfferingPrice" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="instant" />
  <xs:element name="ProceedsFromFutureSalesOfCommonStockUnderAgreementWithInvestmentBank" id="pgnx_ProceedsFromFutureSalesOfCommonStockUnderAgreementWithInvestmentBank" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="instant" />
  <xs:element name="FundingAndFinancialMattersAbstract" id="pgnx_FundingAndFinancialMattersAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="NumberOfYearsCashIsSufficientToFundOperations" id="pgnx_NumberOfYearsCashIsSufficientToFundOperations" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" />
  <xs:element name="PublicOfferingAbstract" id="pgnx_PublicOfferingAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="ShareholdersAcceptancePercentage" id="pgnx_ShareholdersAcceptancePercentage" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="instant" />
  <xs:element name="ExiniMember" id="pgnx_ExiniMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="WeightedAverageCommonSharesDenominatorAbstract" id="pgnx_WeightedAverageCommonSharesDenominatorAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="PerShareAbstract" id="pgnx_PerShareAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="ShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice" id="pgnx_ShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" />
  <xs:element name="OptionsMember" id="pgnx_OptionsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="DilutiveEffectOfPotentialSettlementOfContingentConsiderationLiability" id="pgnx_DilutiveEffectOfPotentialSettlementOfContingentConsiderationLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" />
  <xs:element name="DilutiveEffectOfPotentialSettlementOfContingentConsiderationLiabilityShares" id="pgnx_DilutiveEffectOfPotentialSettlementOfContingentConsiderationLiabilityShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" />
  <xs:element name="ProceedsFromPublicOfferingOfCommonStockNetOfUnderwritingDiscountsAndCommissionsAndOfferingExpenses" id="pgnx_ProceedsFromPublicOfferingOfCommonStockNetOfUnderwritingDiscountsAndCommissionsAndOfferingExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" />
  <xs:element name="DocumentAndEntityInformationAbstract" id="pgnx_DocumentAndEntityInformationAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="ActivityRelatedToGoodwillAndIndefiniteLivedIntangibleAssetsTextBlock" id="pgnx_ActivityRelatedToGoodwillAndIndefiniteLivedIntangibleAssetsTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" />
  <xs:element name="GoodwillAndIndefiniteLivedInProcessResearchAndDevelopmentAbstract" id="pgnx_GoodwillAndIndefiniteLivedInProcessResearchAndDevelopmentAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="ImpairmentOfIndefiniteIntangibleAssetsExcludingGoodwill" id="pgnx_ImpairmentOfIndefiniteIntangibleAssetsExcludingGoodwill" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" />
</xs:schema>
</XBRL>