| Filed by the Registrant                    | x |
|--------------------------------------------|---|
| Filed by a Party other than the Registrant | o |
| Check the appropriate box: |
|----------------------------|
| o | Preliminary Proxy Statement                                                     |
|---|---------------------------------------------------------------------------------|
| o | Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) |
| o | Definitive Proxy Statement                                                      |
| x | Definitive Additional Materials                                                 |
| o | Soliciting Material Pursuant to Rule 14a-12                                     |
| Payment of Filing Fee (Check the appropriate box): |
|----------------------------------------------------|
| x                                                  | No fee required. |
| o                                                  | Fee computed on table below per Exchange Act Rules 14a-6(i)(2) and 0-11. |
|                                               | (1) | Title of each class of securities to which transaction applies: |
|                                               | (2) | Aggregate number of securities to which transaction applies: |
|                                               | (3) | Per unit price or other underlying value of transaction computed pursuant to Exchange Act Rule 0-11 (set forth the amount on which the filing fee is calculated and state how it was determined): |
|                                               | (4) | Proposed maximum aggregate value of transaction: |
|                                               | (5) | Total fee paid: |
| o                                                  | Fee paid previously with preliminary materials. |
| o                                                  | Check box if any part of the fee is offset as provided by Exchange Act Rule 0-11(a)(2) and identify the filing for which the offsetting fee was paid previously. Identify the previous filing by registration statement number, or the Form or Schedule and the date of its filing. |
|                                               | (1) | Amount Previously Paid: |
|                                               | (2) | Form, Schedule or Registration Statement No.: |
|                                               | (3) | Filing Party: |
|                                               | (4) | Date Filed: |

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| VOTE BY INTERNET - www.proxyvote.comUse the Internet to transmit your voting instructions and for electronic delivery of information up until 11:59PM EDT on the day before the cut-off date or meeting date. Have your proxy card in hand when you access the web site and follow the instructions to obtain your records and to create an electronic voting instruction form.ELECTRONIC DELIVERY OF FUTURE PROXY MATERIALSIf you would like to reduce the costs incurred by our company in mailing proxy materials, you can consent to receiving all future proxy statements, proxy cards and annual reports electronically via e-mail or the Internet. To sign up for electronic delivery, please follow the instructions above to vote using the Internet and, when prompted, indicate that you agree to receive or access proxy materials electronically in future years.VOTE BY PHONE - 1-800-690-6903Use any touch-tone telephone to transmit your voting instructions up until 11:59PM EDT on the day before the cut-off date or meeting date. Have your proxy card in hand when you call and then follow the instructions.VOTE BY MAILMark, sign and date your proxy card and return it in the postage-paid envelope we have provided or return to Vote Processing, c/o Broadridge, 51 Mercedes Way, Edgewood, NY 11717.VOTE IN PERSONAttend the Annual Shareholders Meeting at 10:00AM EDT on Wednesday, June 12, 2013.The Landmark at EastviewRockland Room777 Old Saw Mill River RoadTarrytown, NY 10591 |
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| TO VOTE, MARK BLOCKS BELOW IN BLUE OR BLACK INK AS                             |                               |
|--------------------------------------------------------------------------------|------------------------------------|
| FOLLOWS:                                                        | KEEP THIS PORTION FOR YOUR RECORDS |
| DETACH AND RETURN THIS PORTION ONLY                                            |
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| THIS PROXY CARD IS VALID ONLY WHEN SIGNED AND DATED.                           |
| PROGENICS PHARMACEUTICALS, INC.                                                |
|  The Board of Directors recommends you vote FOR the Nominees named below: |
|                                                                           |
| 1. Election of Directors                                             |
| NOMINEES:               |        |         |         |        |
|-------------------------|--------|---------|---------|--------|
|                    | For    | Against | Abstain |   |
|                    |   |    |    |   |
| 01) Peter J. Crowley    | ¨ | ¨  | ¨  |   |
| 02) Paul J. Maddon      | ¨ | ¨  | ¨  |   |
| 03) Mark R. Baker       | ¨ | ¨  | ¨  |   |
| 04) Stephen P. Goff     | ¨ | ¨  | ¨  |   |
| 05) David A. Scheinberg | ¨ | ¨  | ¨  |   |
| 06) Nicole S. Williams  | ¨ | ¨  | ¨  |   |
|                                                                                                                                                                                     | For    | Against | Abstain |   |
|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|---------|---------|--------|
| 2. Approval, on an advisory basis, of the compensation of the Company's named executive officers as disclosed in this year's Proxy Statement.                                            | ¨ | ¨  | ¨  |   |
|                                                                                                                                                                                     |   |    |    |   |
| 3. Approval of an amendment to the Company's Restated Certificate of Incorporation to increase the number of authorized shares of common stock from 80 million to 160 million. | ¨ | ¨  | ¨  |   |
|                                                                                                                                                                                     |   |    |    |   |
| 4. Approval of an amendment to the Company's 2005 Stock Incentive Plan to increase the number of shares of common stock reserved for issuance thereunder from 8,450,000 to 10,450,000.   | ¨ | ¨  | ¨  |   |
|                                                                                                                                                                                     |   |    |    |   |
| 5. Ratification of the selection of Ernst & Young LLP to serve as the Company's independent registered public accounting firm for 2013.                                         | ¨ | ¨  | ¨  |   |
|                                                                                                                                                                                     |   |    |    |   |
| Please sign exactly as your name(s) appear(s) hereon. When signing as attorney, executor, administrator, or other fiduciary, please give full title as such. Joint owners should each sign personally. All holders must sign. If a corporation or partnership, please sign in full corporate or partnership name, by authorized officer. |   |   |   |
|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|--------|--------|
|                               |   |   |                     |   |
|------------------------------------|--------|--------|--------------------------|--------|
| Signature [PLEASE SIGN WITHIN BOX] | Date   |   | Signature (Joint Owners) | Date   |

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| PROGENICS PHARMACEUTICALS, INC.ANNUAL MEETING OF STOCKHOLDERSJUNE 12, 2013 - 10:00AMTHIS PROXY IS SOLICITED BY THE BOARD OF DIRECTORS                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     |
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|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      |
| The undersigned(s) hereby appoint(s) Mark R. Baker and Angelo W. Lovallo, Jr., and each of them, as proxies, each with the power to appoint his substitute, and hereby authorizes them to represent and to vote, as designated on the reverse side of this ballot, all of the shares of common stock of PROGENICS PHARMACEUTICALS, INC. that the stockholder(s) is/are entitled to vote at the Annual Meeting of Stockholders to be held at 10:00AM EDT on June 12, 2013, at The Landmark at Eastview, 777 Old Saw Mill River Road, Tarrytown, NY 10591, Rockland Room, and any adjournment or postponement thereof. |
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| THIS PROXY, WHEN PROPERLY EXECUTED, WILL BE VOTED IN THE MANNER DIRECTED HEREIN. IF NO DIRECTION IS MADE, THIS PROXY WILL BE VOTED IN ACCORDANCE WITH THE BOARD OF DIRECTORS' RECOMMENDATIONS.                                                                                                                                                                                                                                                                                                                                                                                                                  |
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| (Continued and to be signed on the reverse side)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          |