Exhibit 10.18 


 


PURDUE TECHNOLOGY CENTER


 


3000
KENT AVENUE


 


WEST
LAFAYETTE, INDIANA 47906


 


LEASE AGREEMENT


 


THIS LEASE AGREEMENT (the “Lease”)
is made and entered into as of this 8th day of December, 2015, by and between PURDUE RESEARCH FOUNDATION (“Landlord”),
an Indiana corporation (formed and existing under the Indiana Foundation or Holding Companies Act, Acts of 1921, ch. 246), and
ENDOCYTE (“Tenant”).


 


1.          DESCRIPTION
OF THE LEASED PROPERTY. Subject to the terms and conditions of this Lease, Landlord does demise and lease to Tenant, and Tenant
hire from Landlord certain property being described as follows:


 


25,411 SQUARE FEET OF SPACE DESIGNATED AS SUITES
A1-100, A1-200, B1-008, B1-100A, B1-200, B1-300, B1-400, B1-500, A2-100, A2-300, B2-300, B2-400, B2-500, B2-603, B2-700 AND B2-900
(the “Leased Property”) located in the PURDUE TECHNOLOGY CENTER at 3000 Kent Avenue, West Lafayette, IN (the “Building”)
in the PURDUE RESEARCH PARK (the “Park”). The Leased Property is more particularly shown on EXHIBIT A, attached
to this Lease and made a part of this Lease by this reference.


 


2.          USE
OF LEASED PROPERTY. Tenant shall use the Leased Property for the usual complement of laboratory facilities, offices, or light
industrial purposes in accordance with the zoning restrictions placed on the Leased Property by the local governing agencies. Tenant,
at its own expense, shall obtain all licenses, permits, and other governmental approvals that are required for or occasioned by
the conduct of Tenant’s business and occupancy of the Leased Property. Tenant agrees to occupy the entire Leased Property
during the Lease Term in accordance with the Purdue Technology Center Development Policy, which is attached to this Lease as EXHIBIT
B. Tenant also agrees to occupy the entire Leased Property during the Lease Term and to conduct Tenant’s business at
all times in good faith, in a high grade and reputable manner.


 


This Lease supersedes any and all prior
lease and/or affiliate agreements between the parties pertaining to the Leased Property.


 


		3.	TERM.



 


		a.	Initial Term. The "Initial Term" of this Lease
shall be Twelve (12) months, commencing on January 1, 2016 (the "Commencement Date"), and continuing for Twelve
(12) consecutive months until December 31, 2016, at 5:00 p.m. (the “Termination Date”), unless earlier terminated
as provided in this Lease.



 




     

     


    

 


		b.	Extension Period(s). Tenant shall have the option to
extend the Initial Term for Two (2) periods of Twelve (12) months each (the “Extension Period(s)"). The approval of
the Extension Period(s) shall be confirmed in writing using the form (the “Extension of Lease Form”) as shown in the
attached EXHIBIT C of this Lease. Approval of the Extension of Lease Form shall be contingent upon (a) Landlord having
received no written notice from Tenant of Tenant's intent to terminate the Lease at the end of the then current Lease Term which
notice must be received by Landlord at least sixty (60) days prior to the end of the then current Lease Term, (b) Tenant is not
in default under any of the terms or conditions of this Lease at the time it exercises such option, (c) this Lease shall not have
been terminated during the Initial Term or any Extension Period, and (d) Landlord is willing to extend this Lease. All other terms
and conditions of this Lease shall be applicable to such Extension Period(s).



 


		c.	The Initial Term and any Extension Period(s) under this
Lease are referred to herein as the “Lease Term.”



 


		4.	RENT.



 


		a.	Base Rent.



 


		i.	Initial Term. For the Initial Term, Tenant agrees to
pay to Landlord rent in the minimum aggregate amount of Five Hundred Ninety Seven Thousand Forty-Six and 44/100 Dollars
($597,046.44) (the "Rent"). Tenant agrees to pay the Rent in consecutive monthly installments ("Monthly
Rent Installment") of Forty Nine Thousand Seven Hundred Fifty-Three and 87/100 Dollars ($49,753.87) per month,
in advance of the first day of each month, commencing at the Commencement Date, as defined herein. The Rent is equal to $18.06
per square foot for the portion of the Leased Property devoted to office uses; and $33.96 per square foot for the portion of the
Leased Property used as a laboratory, per year during the Initial Term.



 


During the Initial Term and any subsequent Extension
Periods, the Rent shall be adjusted annually and effective January 1st. Each year during the Lease Term, the Rent shall
be equal to the rental rate established for the Building (“Building Rate”) for the subsequent calendar year multiplied
by the square feet occupied by Tenant and shall remain in effect until the Building Rate changes. The Building Rate shall be determined
by Landlord and provided, by written notice, to Tenant not later than November 1st of each calendar year. The Building
Rate increase shall not exceed five percent (5%) during any given year. In no event shall the Rent be adjusted more frequently
than annually. The new Rent as so adjusted shall begin each calendar year on January 1st and continue at the adjusted
rate until the next annual adjustment of the Building Rate. The corresponding Monthly Rent Installment shall also be adjusted to
be consistent with the change in the Rent.


 


		ii.	The Monthly Rent Installment shall be prorated for periods
at the beginning and end of the Lease Term, as defined herein, which do not constitute full calendar months.



 




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		b.	Late Fee. If Landlord does not receive any payment of
the Monthly Rent Installment or any other amounts to be paid to Landlord when due, a fee of Fifty Dollars ($50) will be charged
on the fifth day after such payment is due and owing plus Five Dollars ($5) for each day thereafter (collectively the “Late
Charges”) until payment is received. The accrued Late Charges are in addition to the Monthly Rent Installment, and are due
with the payment of the outstanding Monthly Rent Installment. Landlord’s receipt of Late Charges does not waive the right
of Landlord to evict Tenant for nonpayment of Rent if Landlord so elects.



 


		c.	Returned Check Fee. If a check is returned from the bank
for any reason, a Twenty-Five Dollar ($25.00) fee will be assessed, plus the applicable Late Charges until the outstanding Monthly
Rent Installment is paid in full.



 


		d.	Rent Payments. The Monthly Rent Installment payments
and any other sums due Landlord hereunder shall be payable at Landlord’s principal office at 1281 Win Hentschel Boulevard,
West Lafayette, IN 47906. All Rent and any other sums owed by Tenant under this Lease shall be payable without notice or demand
and without deduction, diminution, abatement, counterclaim, or set off of any amount or for any reason whatsoever, and without
relief from valuation or appraisement laws and with attorney’s fees.



 


5.          TENANT
EVALUATION & REPORTING. Tenant agrees that upon Landlord’s request, Tenant will provide information regarding Tenant’s
business unless prevented from doing so by Tenant confidentiality agreements. This information may include but not be limited to
growth in revenue, employment statistics (job classification, level of education, salary range, number of Purdue University graduates),
business plan, and other statistical data that may be necessary for Landlord to evaluate Tenant’s business and to prepare
reports that may be necessary to demonstrate the economic impact of companies within the Building and/or the Park. Landlord agrees
to keep such information confidential upon the request of Tenant and Landlord is willing to execute a confidentiality agreement
with Tenant upon request of Tenant. __________


 


6.          BUILDING
SERVICES PROGRAM. Landlord agrees to provide Tenant with a copy of the facilities and programs (“Building Services Program”)
available to Tenant because of its occupancy of the Leased Property. The Building Services Program will outline a variety of facilities
and programs including, but not limited to conference rooms, copy machines, fax machines, building kitchen, and a variety of other
business and financial management programs. The Building Services Program will indicate whether a special fee applies to participation
in the use of a facility or program and Tenant agrees to pay such fees for its use of any portion of the Building Services Program.
Tenant shall have the nonexclusive right during the Lease Term to use the shared facilities and equipment, and to have access to
the shared services described in the Building Services Program in consideration of the usage fees published from time to time by
Landlord for such services. Usage shall be available on a first-come, first-serve basis. Landlord reserves the right to change
the facilities, equipment, services, and fees in the Building Services Program from time to time. All facilities, equipment, and
services described in the Building Services Program shall be used in common with Landlord and other Tenants in the Building. Landlord
makes no assurances that such shared equipment will be operational at all times, but Landlord will keep such shared equipment in
reasonable condition and repair. Further, Landlord makes no assurances that certain shared facilities or equipment (e.g., conference
rooms, etc.) will be available at all times. Tenants are encouraged to reserve use of any conference rooms reasonably in advance
of any activity during which Tenant desires to use the conference rooms.


 




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7.          COMMON
AREAS. To the extent applicable, Tenant shall have the non-exclusive right, in common with all other tenants in the Building
and subject to any rules and regulations adopted from time to time by Landlord concerning the Building, to use the areas in and
around the Building designated by Landlord from time to time as common areas, including, but not limited to, toilet facilities,
hallways, stairs, and elevators (the "Building Common Areas"). Landlord shall operate, maintain, and insure the Building
Common Areas for their intended purposes in such a manner as Landlord shall determine to be necessary or appropriate, including,
without limitation that Landlord at any time may close or change any part of the Building Common Areas as it determines to be necessary
or appropriate.


 


8.          LANDLORD’S
WORK. Landlord has constructed and completed the Building and all tenant improvements as it relates to the Leased Property.
Landlord reserves the right to make changes, reductions, and additions without restriction in other areas of the Building (including
all Building Common Areas, the Park Common Areas, and the Park), whether the changes are requested by other tenants, other building
owners, or deemed desirable by Landlord.


 


9.          TENANT’S
WORK. Tenant agrees to accept the Leased Property in its present "AS IS" condition. Further alterations of the Leased
Property will be at Tenant's sole expense (unless otherwise stated in this Lease) and deemed to be Tenant's Work. Tenant and Landlord
shall approve and attach an EXHIBIT D (“Plan of Work”) to this Lease that shall include any drawings, statements
of items being provided by Tenant and Landlord in the Leased Property and any other necessary items that are needed to clarify
Tenant and Landlord responsibilities for the condition of the Leased Property at the Commencement Date. Both Tenant and Landlord
shall approve the Plan of Work as soon as possible following the execution of this Lease. Both Tenant and Landlord must approve
any changes to the Plan of Work, in writing, prior to proceeding with the changes. Approval of plans and specifications by Landlord
shall not constitute the assumption of any responsibility by Landlord for their accuracy or sufficiency or conformity with applicable
laws, and Tenant shall be solely responsible for such plans and specifications and for all of Tenant's Work. Tenant shall not commence
any of Tenant's Work until Landlord has approved EXHIBIT D.


 


Tenant's taking possession of the Leased
Property shall be conclusive evidence of Tenant's acceptance thereof in good order and satisfactory condition. Tenant agrees that
Landlord has made no representations as to conformance with applicable laws respecting the condition of the Leased Property or
the presence or absence of Hazardous Materials (hereinafter defined) in, at, under or abutting the Leased Property or the environment.
Tenant also agrees that no representations respecting the condition of the Leased Property, no warranties or guarantees, expressed
or implied, INCLUDING, WITHOUT LIMITATION, ANY IMPLIED WARRANTY OF HABITABILITY, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE,
with respect to workmanship or any defects in material, and no promise to decorate, alter, repair or improve the Leased Property
either before or after the execution hereof, have been made by Landlord or its agents to Tenant unless the same are contained herein.


 


10.         ADDITIONAL
SPACE. The rent for space added to the Leased Property will be equal to the Rent at the time the space is added as calculated
on an annual per square foot cost multiplied by the square foot measurement of the additional space. In the event the additional
space does not open into the main public corridor, the square footage uses for the calculation of the rent for the additional space
may include a prorata share of the square footage of the public corridor providing access to the additional space. If Tenant and
Landlord agree to add additional space to the Leased Property, the price of that space, as determined above, shall be added to
the Rent and also the calculated monthly installment shall be added to the Monthly Rent Installment.


 




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11.         INSTALLATIONS.
Tenant shall at Tenant's expense furnish and install all fixtures, equipment and furnishings, and all electric wiring and fixtures
needed in addition to those now installed in the Leased Property. Any fixtures or other equipment furnished by Tenant which can
be seen from the outside of the Leased Property shall be of such type and quality and so located as to present a sightly appearance
from the outside and shall require the prior written approval of Landlord. Tenant shall at Tenant's expenses furnish and install
any equipment or furnishings, within the Leased Property, necessary to maintain compliance with fire and safety codes or the Americans
with Disabilities Act Accessibility Guidelines for Buildings and Facilities.


 


12.         ALTERATIONS,
CHANGES, IMPROVEMENTS AND ADDITIONS. It is understood and agreed between the parties hereto that Tenant shall make no alterations,
changes, improvements or additions to the Leased Property without the prior written consent and approval of Landlord, which consent
shall not be unreasonably withheld. All alterations, changes, improvements and additions shall be made so as to ensure, to the
maximum extent feasible, that the altered portion(s) and/or addition(s) are readily accessible to and usable by individuals with
disabilities, including individuals who use wheelchairs. All alterations, changes, improvements and additions shall comply with
the Americans with Disabilities Act Accessibility Guidelines for Buildings and Facilities. All alterations, changes, improvements
and additions which affect or could affect the usability of, or access to, an area of a facility that contains a primary function,
i.e. an area of major activity for the intended use of the facility, shall be made so as to ensure that, to the maximum extent
feasible, the path of travel to the altered portion(s) and/or addition(s) and the rest rooms, telephones, and drinking fountains
serving the altered portion(s) and or addition(s), are readily accessible and usable by individuals with disabilities, including
individuals who use wheelchairs, unless the cost and scope of such alterations is disproportionate to the cost of the overall alterations.
Landlord reserves the right before approving any such alterations, changes, improvements and additions to analyze the factual basis
underlying Tenant’s determinations that the cost and scope of alterations which trigger the path of travel requirements is
disproportionate to the cost of the overall alterations. Landlord reserves the right before approving any such alterations, changes,
improvements or additions to require Tenant to furnish to Landlord, at Tenant’s expense, a good and sufficient bond conditioned
that Tenant shall protect, indemnify, defend and hold Landlord harmless from the payment of any claims, either by way of damages
or liens. All of such alterations, changes, improvements or additions shall be made solely at the expense of Tenant, and Tenant
agrees to protect, indemnify, defend and hold harmless Landlord on account of any injury or death to third persons or property
by reason of such alterations, changes, improvements or additions, and to protect, indemnify, defend and hold harmless Landlord
from the payment of any and all claims of any kind or character on account of bills for labor or materials in connection therewith.
All alterations, changes, improvements and additions installed on the Leased Property including but not limited to plumbing, wiring
and lighting fixtures, water use improvements, heating and air conditioning, ventilating and exhaust systems, extensions, fume
hoods, wet labs, and all other improvements of any nature other than unattached and movable trade fixtures of Tenant, shall, upon
termination of this Lease, become the property of Landlord, without payment therefor, free and clear of any claims of Tenant with
the exception of those which can be removed by Tenant without damage to the Leased Property, or with the understanding between
Landlord and Tenant that Tenant will repair at Tenant’s sole cost and expense, any damage resulting from such removal, and
in a fashion acceptable to Landlord.


 


The location, installation and use of all
outside lighting for the illumination of the Leased Property, all exterior advertising and display signs, and the use of outside
music and outside loudspeakers of any type by Tenant shall be prohibited unless otherwise approved in writing by Landlord.


 




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13.         MAINTENANCE
AND REPAIRS. Landlord agrees to keep the exterior of the Building, including the roof, exterior wall, gutters, downspouts,
and the supply pipes for water leading to the Leased Property and the drainage pipes leading therefrom in good structural repair,
except that Landlord shall not be required to pay for any such repairs or replacements which become necessary by reason of the
negligence of Tenant, its agents, servants or employees. Tenant agrees to maintain the interior of the Leased Property and any
alterations, changes, improvements and additions, and all equipment thereof and therein, including, but not limited to, maintenance
of all windows and doors, at all times in good and sufficient repair, order and condition, and to pay all costs and expenses thereof,
both ordinary and extraordinary, and all such materials, repairs and workmanship shall be equal, in Landlord’s opinion, in
class and quality to that originally placed in the Leased Property provided, however, that it shall not be required to perform
any maintenance, repairs or replacements necessitated by the negligence of Landlord, its servants, agents or employees, by structural
defect in the building by fire or other casualty.


 


14.         SERVICES
AND UTILITIES.


 


Gas, electric, water and sewage utilities
shall be included in and a part of the Monthly Rent Installment; however, if Tenant has equipment that utilizes more utilities
than would be required for a normal office setting, Landlord reserves the right to charge Tenant an amount equal to the anticipated
additional utility costs.


 


Access to the fiber line and other telecommunication
services will be contingent upon Tenant paying associated fees. Further charges may be levied for certain services provided with
written notice in advance as specified in the Building Services Program.


 


Tenant understands, acknowledges and agrees
that any one or more of the utilities or other building services may be interrupted by accident, emergency or other causes beyond
Landlord's control, or may be discontinued or diminished temporarily by Landlord or other persons until certain repairs, alterations
or improvements can be made; that Landlord does not represent or warrant the uninterrupted availability of such utilities or building
services; that any such interruption shall not be deemed an eviction or disturbance of Tenant's right to possession, occupancy,
and use of the Leased Property or any part thereof, or render Landlord liable to Tenant for damages by abatement of Rent or otherwise,
or relieve Tenant from the obligation to perform its covenants under this Lease; and that Landlord shall not be liable to Tenant
for any injury, loss or damage occasioned by the bursting, stoppage or leaking of water, gas, sewer, or other pipes. Landlord shall
have no liability to Tenant (including without limitation liability for consequential damages or loss of business income or opportunity)
arising out of, resulting from, or related to any such interruption of services provided herein.


 


15.         PARKING
AREA. Tenant for itself, its employees, customers and invitees, shall have the non-exclusive right during the Lease Term and
all renewals thereof, to use the parking area, adjacent to the Building, in common with Landlord and Landlord’s other tenants,
their employees, customers and invitees. Said parking area shall be for the joint use of Landlord and all tenants in the Park and
for the use of the customers, employees, visitors, and invitees of said tenants for driveway, walking or parking purposes. If an
employee parking area is established, Tenant shall require Tenant’s employees to park therein. Tenant shall not at any time
interfere with the right of Landlord and Landlord’s other tenants, their employees, customers and invitees, to use any part
of said parking area.


 


16.         TAXES.
Landlord agrees to pay all State, County, and Municipal property taxes and assessments, prior to delinquency, levied against the
land covered by this Lease and all improvements thereon. Tenant agrees to pay all taxes on personal property maintained by Tenant
in or upon the Leased Property during the term of the Lease.


 


17.         INSURANCE.
Landlord shall carry, at Landlord’s expense, first party commercial property insurance on the Leased Property. Tenant is
solely responsible for carrying adequate insurance on all Tenant’s personal property including, but not limited to, equipment,
furniture, scientific devices, supplies, personal items, or other items installed and belonging to Tenant and located within the
Leased Property, in addition to the insurance described in Section 21 of this lease.


 




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18.         DAMAGE
TO OR DESTRUCTION OF BUILDING. In case of damage by fire or the elements, Tenant shall give immediate notice thereof in writing
to Landlord, stating the extent of damage. If a part only of the Leased Property shall be damaged so as not to render the Leased
Property wholly untenantable, the Monthly Rent Installment shall abate proportionately to the part of the Leased Property rendered
untenantable, and Landlord shall commence within thirty (30) days after said notice to repair the same at its own cost and expense
and complete said repairs with due and reasonable diligence. If the damage shall be so extensive as to render the entire Leased
Property untenantable, the Monthly Rent Installment shall cease from the time notice was given Landlord of such fact by Tenant,
and no payment shall thereafter become due until the Leased Property is restored to a tenantable condition. If the Leased Property
is not restored to a tenantable condition and Tenant admitted to full possession within one hundred and twenty (120) days from
the notice, Tenant may, at Tenant’s option, declare the Lease terminated by giving Landlord written notice of such election
to terminate the same. In such case the monthly rent and any additional rent that may be due shall be apportioned pro rata and
paid up the time of such damage, and this Lease shall terminate.


 


19.         TENANT’S
AGREEMENT. In addition to Tenant’s other responsibilities and obligations under this Lease, Tenant covenants and agrees:


 


a.           not
to obstruct or interfere with the rights of other tenants, or injure or annoy them or those having business with them or conflict
with them, or conflict with the fire laws or regulations, or with any insurance policy upon the Building or any part thereof, or
with any statutes, rules or regulations now existing or subsequently enacted or established by the local, state or federal governments,
and Tenant shall be answerable for all nuisances caused or suffered on the Leased Property, or caused by Tenant and/or its Permittees
(as later defined) in the Building, or on the approaches to the Building;


 


b.           not
to place upon the interior or exterior of the Building, or any window or any part thereof or door of the Leased Property, any placard,
sign, lettering, window covering or drapes, except such and in such place and manner as shall have been first approved in writing
by Landlord, and to use Building standard signage on its suite entry door;


 


c.           to
be responsible for the cost of removal of Tenant's bulk trash at time of move-in, during occupancy, and move-out;


 


d.           not
to permit the commitment of any waste upon or to the Leased Property, Building, and/or Park; and


 


e.           to
comply with all statutes, municipal and police regulations, and ordinances of Federal, State, City and County governments and agencies
or other public authority directed against or in any way affecting the Leased Property or Tenant’s business conducted therein
at all times during the Lease Term.


 


20.         LIABILITY
FOR DAMAGES TO THE BUILDING, THE PARK, AND/OR ANY OTHER PROPERTY OF LANDLORD. Tenant will be solely responsible for any damage
to the Building, the Park, and/or any other property of Landlord resulting from use of the Leased Property or any act done thereon
by Tenant or any person coming or being thereon with the permission, expressed or implied, of Tenant.


 




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21.         DUTY
TO INDEMNIFY FROM THIRD-PARTY CLAIMS. Tenant agrees to indemnify, defend, and hold harmless Landlord against and from any and
all losses, expenses, and damages extending from claims brought by or on behalf of any person or persons, firm or firms, corporation
or corporations for damages, either to person or property, resulting from Tenant’s use of the Leased Property. Tenant further
agrees to indemnify, defend, and hold harmless Landlord against and from any and all losses, expenses, and damages extending from
claims brought by or on behalf of Tenant or any person in the Leased Property, the Building, and/or the Park with Tenant’s
consent, invitation or license, expressed or implied, for any damage, either to person or property, sustained by reason of the
condition of the Leased Property, the Building, the Park, or any part thereof, due to the negligence of any employee of Tenant,
or the negligence of any other persons in the Leased Property, or due to any casualty or accident in or about the Leased Property,
including those arising from the bursting or leaking of any water, gas, sewer, or steam pipes, or from the breaking, shorting or
malfunction of any electrical wiring or apparatus.


 


Tenant acknowledges that Tenant’s
employees are not employees of Landlord, and therefore not eligible for any benefits or coverages normally and ordinarily available
to Landlord’s employees. Therefore, Tenant will obtain and keep in force workers’ compensation insurance to cover losses
resulting from bodily injury to Tenant’s employees and contractors. Tenant further agrees to obtain and keep in force a commercial
general liability insurance policy in an amount not less than One Million Dollars ($1,000,000.00) single limit, per occurrence,
to cover losses resulting from bodily injury or property damage to third parties. The coverage amount may be changed by Landlord
over time, to insure that the coverage is consistent with industry standards. Tenant agrees to place such coverage with companies
satisfactory to Landlord and to name Landlord as an additional insured under any commercial general liability insurance policy.
Tenant agrees to provide Landlord on at least an annual basis satisfactory evidence that the required coverages are in force. Such
insurance shall cover electric displays and signs located on the Leased Property.


 


22.         MECHANIC’S
LIEN. Tenant shall not suffer or permit any mechanic’s liens to be filed against the fee of the Leased Property not against
Tenant’s leasehold interest in the Leased Property by reason of work, labor, services or materials supplied or claimed to
have been supplied to Tenant. If any such mechanic’s liens shall at any time be filed against the Leased Property or against
Tenant’s leasehold interest, Tenant shall, within forty-five (45) days after notice of the filing thereof, cause the same
to be discharged of record by payment, deposit, bond, order of court of competent jurisdiction or otherwise. Nothing in this Lease
contained shall be deemed or construed in any way as constituting the consent or request of Landlord, expressed or implied, by
inference or otherwise, to any contractor, subcontractor, laborer or materialman for the performance of any labor or furnishing
of any materials for any specific improvement, addition, alteration or repair of or to the Leased Property or any part thereof,
nor as giving Tenant a right, power or authority to contract for or permit the rendering of any services or the furnishing of any
materials that would give rise to the filing of any mechanic’s lien against the fee of the Leased Property.


 




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23.         RIGHTS
ON DEFAULT. If Tenant shall be in default of any of the terms, conditions, covenants, agreements or provisions of this Lease
and shall fail to cure such default or defaults within twenty (20) days after written notice thereof, or if the rent shall be in
arrears for ten (10) days as to any Monthly Rent Installment and Tenant shall fail to pay in full the arrearages in rent within
five (5) days after written notice thereof, then in either such circumstance this Lease shall immediately terminate at the sole
option and election of Landlord without any notice to Tenant. If Tenant shall be adjudged bankrupt, either by voluntary or involuntary
proceedings, or if a receiver, trustee or other representative for creditors be appointed, or if Tenant shall make a general assignment
for the benefit of creditors, then this Lease shall immediately terminate at the sole option and election of Landlord upon notice
of such election being given to Tenant or to such trustee, receiver, assignee or representative, as the case may be, within thirty
(30) days after Landlord shall acquire knowledge of the happening of such event. Landlord shall, at any such time and in any of
such events, and/or defaults in addition to and without thereby waiving any of Landlord’s other rights or remedies, have
the right to immediate and peaceable possession of the Leased Property without notice, and Landlord may lawfully enter into and
upon the Leased Property or any part thereof in the name of the whole, and repossess the same, and expel Tenant and those claiming
under and through Tenant and remove Tenant’s effects, without being deemed guilty of any manner of trespass upon entry as
aforesaid, and this Lease shall terminate and wholly expire, and Tenant covenants that in case of such termination, Tenant will
indemnify Landlord against all loss of rent Landlord may incur by reason of such termination during the residue of the term above
specified.


 


The failure of Landlord to exercise any
of its rights or remedies under this Lease upon any default by Tenant shall not be deemed a waiver of any such default nor of any
of the provisions of this Lease and shall not preclude Landlord from the exercise of any such rights and remedies upon any subsequent
date whether for a previous or subsequent default.


 


24.         RELOCATION
OF TENANT. Landlord shall have the right upon at least thirty (30) days' prior written notice to Tenant to relocate Tenant
and to substitute for the Leased Property other space in the Building, or in another building owned by Landlord, in the vicinity
containing at least as much rentable area as the Leased Property. Such substituted space shall be improved by Landlord, at its
expense, with improvements at least equal in quantity and quality to those in the Leased Property. Landlord shall reimburse Tenant
for all reasonable expenses incurred in connection with such relocation. In no event shall Landlord be liable to Tenant for any
consequential damages as a result of any such relocation, including, but not limited to, loss of business income or opportunity.


 


25.         USE
AND OCCUPANCY. Tenant covenants that no waste shall be committed upon or to the Leased Property; that the Leased Property shall
be used for the purpose herein above stated, and shall not be used or permitted to be used for any other purpose; that the Leased
Property shall not be used for any unlawful purpose and no violations of law or ordinance shall be committed thereon; that no intoxicating
beverages shall be sold, served or stored illegally upon or from the Leased Property; and that nothing shall be done or suffered
or any substance kept on the Leased Property which will operate to increase the fire hazard or to cause the insurance rates thereon
to be increased. Tenant shall not abuse walls, ceilings, partitions, floors, wood, stone and brick, and iron work; nor use plumbing
and electrical wiring for any purpose other than that for which constructed; nor create, maintain, or permit a nuisance therein;
nor do any act tending to injure the reputation of the Park. Tenant shall not perform any acts nor carry on any practices which
may injure the Leased Property or be a nuisance or menace to other tenants in the Park, and shall store all trash and garbage within
the Leased Property, or within containers provided for regular city pickup. If the amount of trash and garbage is too excessive
for regular city pickup, Tenant will arrange for pickup and cartage of all excess trash and garbage at Tenant’s expense.
Tenant shall not burn any trash or garbage at any time in or about the Leased Property or anywhere else in the Park; provided,
however, that Landlord may in its sole discretion permit the burning of trash on the Leased Property or incinerators to be furnished
by Tenant and approved by Landlord. Tenant shall at all times during the Lease Term comply with all statutes, municipal and police
regulations, and ordinances of Federal, State, City and County governments and agencies or other public authority directed against
or in any way affecting the Leased Property or Tenant’s business conducted therein.


 


Tenant shall not permit (a) any release
of any hazardous substance from the Leased Property; (b) any unlawful, harmful or improper discharge from the Leased Property into
the surrounding atmosphere or into the sewers, drains and waterways on or adjacent to the Leased Property, or the groundwater thereunder;
(c) any harmful or improper disposal of liquid or solid waste (hazardous or otherwise) generated on, stored at or transported from
the Leased Property. As used in this Section, the terms "hazardous substance," "release" and "removal"
shall have the same meaning and definition as set forth in paragraphs (14), (22) and (23), respectively, of 42 U.S.C. § 9601
and in I.C. 13-7-8.7-1: provided, however, that the term "hazardous substance" as used herein also shall include "hazardous
waste" (as defined in paragraph (5) of 42 U.S.C. § 6903) and "petroleum" (as defined in paragraph (8) of 42
U.S.C. § 6991).


 




    	 	— 9 —	 



     


    

 


26.         ACCESS
TO LEASED PROPERTY. Landlord may at reasonable times, and providing reasonable notice is given to Tenant by Landlord prior
to inspection, enter to view and inspect the Leased Property or to make repairs, and may show the Leased Property to others and
may at any time within two months next preceding the termination of this Lease affix to any suitable part of the Leased Property
a notice for letting the Leased Property, and keep the same affixed without hindrance or molestation.


 


27.         HOLDOVER.
If Tenant shall occupy the Leased Property with the consent of Landlord after the expiration of this Lease, and rent is accepted
from Tenant, such occupancy and payment shall be construed as an extension of this Lease for a term of one month only from the
date of such expiration, and occupancy thereafter shall operate to extend the terms of this Lease for but one month at a time,
unless other terms of such extension are endorsed hereon in writing and signed by the parties hereto or unless such other terms
are reduced to a separate writing signed by the parties hereto.


 


28.         VACATION
OF THE LEASED PROPERTY. Tenant covenants and agrees to pay the rent at the times and in the manner aforesaid, and at the termination
of this Lease shall peacefully yield up to Landlord the Leased Property in as good order and repair as when delivered to Tenant,
damage by fire, casualty, war or insurrection, riot or public disorder, or act upon the part of any governmental authority, ordinary
wear and tear, and damage by the elements excepted.


 


29.         LIGHT
AND AIR. It is agreed that this Lease does not grant a continuance of light and air over any property adjoining the Leased
Property.


 


30.         EMINENT
DOMAIN. In the event the entire Leased Property, or twenty-five percent (25%) or more in area thereof, shall be appropriated
under the power of eminent domain by any public or quasi-public authority, this Lease shall terminate as of the date of such taking.


 


31.         ASSIGNMENT
AND SUBLETTING. This Lease shall not be assigned or the Leased Property sublet in whole or in part by Tenant without the prior
written consent and approval of Landlord, which approval shall not be unreasonably withheld, and if such consent and approval should
be given, Tenant shall nevertheless remain liable for rents and performance of all other provisions of this Lease as though any
such assignment or subletting has not been made. Landlord shall have the right to sell the Building at any time during the Lease
Term, subject only to the rights of Tenant hereunder. In the event of the sale or exchange of the Building and the assignment of
this Lease, Landlord shall be relieved of all liability for the covenants and obligations in or derived from this Lease, or arising
out of any act, occurrence or omission relating to the Leased Property or this Lease. The covenants, representations, and obligations
of Landlord shall be binding on Landlord only during the period that Landlord has an ownership interest in the Building. Further,
Landlord shall have the right to subordinate this Lease to any mortgage presently existing or hereafter placed upon the Building
by so declaring in such mortgage. Within ten (10) days following receipt of a written request from Landlord, Tenant shall execute
and deliver to Landlord, without cost, any instrument which Landlord deems reasonably necessary or desirable to confirm the subordination
of this Lease and an estoppel certificate in such form as Landlord may reasonably request certifying (i) that this Lease is in
full force and effect and unmodified or stating the nature of any modification, (ii) the date to which rent has been paid, (iii)
that there are not, to Tenant's knowledge, any uncured defaults or specifying such defaults if any are claimed, and (iv) any other
matters or state of facts reasonably required respecting the Lease. Such estoppel may be relied upon by Landlord and by any purchaser
or mortgagee of the Building. Notwithstanding the foregoing, if the mortgagee shall take title to the Leased Property through foreclosure
or deed in lieu of foreclosure, Tenant shall be allowed to continue in possession of the Leased Property as provided for in this
Lease so long as Tenant shall not be in default.


 




    	 	— 10 —	 



     


    

 


32.         RELATIONSHIP
OF PARTIES. Nothing in this Lease shall be deemed or construed by the parties hereto nor by any third party as creating the
relationship of principal and agent or of partnership or of joint venture between the parties hereto, it being understood and agreed
that neither the method of computation of rent nor any other provision of this Lease nor any acts of the parties hereto shall be
deemed to create any relationship between the parties hereto other than the relationship of Landlord and Tenant. In this regard,
although Tenant will have the benefit of various business financial and management programs and services offered to Tenant and
other Tenants in the facility of which the Leased Property are a part, Tenant hereby acknowledges, understands and agrees that
Landlord and all other entities involved in providing programs and services, including but not limited to the Purdue Gateways Program,
shall not be liable for the advice, depth, extent, quality and/or quantity of such management, financial and business programs
and services offered to Tenant hereunder pursuant to such programs and services. Furthermore, Tenant acknowledges and understands
that such programs and services and the people and entities performing them pursuant thereto are merely advisory in nature without
binding effect on Tenant and that Tenant may accept and/or reject such advice and programs and services offered to it. Accordingly,
Tenant agrees that Tenant shall not hold any of the providers of such programs and services responsible or accountable therefore
to any degree or in any manner and Tenant shall be solely responsible for the results and effect of any such programs and services
that are provided to Tenant pursuant to such programs and services.


 


33.         BROKERAGE.
Tenant hereby represents and warrants to Landlord that Tenant has dealt with no broker, finder or other person with respect to
this Lease or the transactions contemplated hereby other than _____ (“Tenant’s Broker”). Tenant shall indemnify,
defend and hold harmless Landlord from and against any loss, liability, damage or claim incurred by reason of any commission or
fee alleged to be payable to anyone other than Tenant’s Broker because of any act, omission, or statement of Tenant, its
employees or agents. Such obligation to indemnify, defend and hold harmless shall be deemed to include the payment of reasonable
attorneys' fees and court costs incurred in defending any such claim. Tenant’s Broker shall be compensated by Landlord per
separate agreement.


 


34.         NOTICES.
All notices to be given hereunder by either party shall be in writing, and shall be sent by certified mail, postage prepaid, addressed
to the party intended to be notified. Notice given as aforesaid shall be a sufficient service thereof and shall be deemed given
as of the date when deposited in any post office, or in any post office box regularly maintained by the Federal Government. Notice
to Tenant and Landlord shall be sent to the following addresses or to such other person or to such other party as either party
may from time to time designate in writing to the other.


 


	Landlord:	Purdue Research Foundation
	 	Real Estate Department
	 	1281 Win Hentschel Boulevard
	 	West Lafayette, IN  47906
	 	 
	Tenant:	Endocyte, Inc.
	 	President and CEO
	 	3000 Kent Avenue, Suite A1-100
	 	West Lafayette, IN  47906


 




    	 	— 11 —	 



     


    

 


35.         CONSTRUCTION.
It is understood that the terms “Landlord” and “Tenant,” used herein, shall be construed to mean Landlords
and Tenants where there is more than one, and the necessary grammatical changes required to make the provisions hereof apply either
to corporations or individuals, men or women, shall in all cases be assumed as though fully expressed. The captions of the various
paragraphs thereof are for convenience only and are not intended to limit or amplify the provisions and terms hereof. This Lease
and any questions arising hereunder shall be construed under the laws of the State of Indiana. If there is more than one Landlord
or Tenant, all obligations of Landlords and Tenants shall be joint and several.


 


36.         WAIVER.
No waiver by either party or their successors or assigns of any breach of the covenants herein contained to be performed by the
other party shall be construed as a waiver of any succeeding breach of the same or any other covenant or condition.


 


37.         EXPRESS
AGREEMENT. It is expressly agreed that neither party has made any statement, promise or agreement or taken upon itself any
obligation whatsoever, verbally, or otherwise, in conflict with the terms of this Lease, or that in any way modifies, varies, alters,
enlarges or invalidates any of its provisions, and no obligation on the part of either party hereto shall be implied in addition
to the obligations herein expressed.


 


38.         MODIFICATION
OR AMENDMENT. This Lease may not be modified or amended except by written agreement signed by the parties hereto.


 


39.         ATTORNEYS
FEES. If, during the Lease Term or afterwards, either party institutes an action, proceeding or counterclaim against the other
relating to this Lease, or a default, the unsuccessful party shall reimburse the successful party for the total amount of court
costs, expenses and reasonable attorneys' fees actually incurred. The giving of a notice of default by Landlord shall constitute
part of an action or proceeding under this Lease, entitling Landlord to reimbursement of its reasonable expenses of attorneys'
fees and disbursements, even if an action or proceeding is not commenced in a court of law and whether or not the default is cured.
This Section shall survive the expiration or termination of this Lease.


 


40.         COUNTERPARTS.
This Lease may be executed in one or more counterparts, each of which will be deemed an original copy of this Lease, and all of
which, when taken together, will be deemed to constitute one and the same agreement. The signature of any party on a fax document
shall be considered to have the same binding legal effects as a signature on an original document.


 


41.         CONCLUSION.
Landlord covenants that Tenant on paying the Rent and performing the covenants herein contained shall and may peacefully and quietly
have, hold and enjoy the Leased Property for the Lease Term. Landlord is not responsible for Tenant’s business success. The
covenants and agreements contained in this Lease shall be binding upon and inure to the benefit of the parties hereto and their
respective heirs, distributees, devisees, legal, and personal representatives, assigns, grantees, and successors in interest.


 




    	 	— 12 —	 



     


    

 


WITNESS the signatures and seals of the above parties
the day and year first above written.


 


	LANDLORD:	PURDUE RESEARCH FOUNDATION
	 	 
	 	an Indiana corporation (formed and existing under the Indiana Foundation or Holding Companies Act, Acts of 1921, ch. 246)
	 	 
	 	By:	/s/ David L. Hodde
	 	 	David L. Hodde
	 	 	Assistant Vice President
	 	 	Director of Real Estate 


 


	ATTEST:	 
	 	 
	By:	/s/ Gregory S. Napier	 
	 	Gregory S. Napier	 
	 	Director Physical Facilities and Purdue Research Parks	 


 


	TENANT:	ENDOCYTE
	 	 
	 	By:	/s/ P. Ron Ellis 
	 	 	P. Ron Ellis
	 	 	President and CEO


 




    	 	— 13 —	 



     


    

 


EXHIBIT A


 


LEASED PROPERTY


 


LEASED PREMISES:


 


	Unit A1-200	Office Space	9,131 square feet
	 	 	 
	Unit B1-008	Office Space	80 square feet
	 	 	 
	Unit B1-100A	Office Space	1,715 square feet
	 	 	 
	Unit B1-200	Office Space	168 square feet
	 	 	 
	Unit B1-201	Office Space	230 square feet
	 	 	 
	Unit B1-202	Office Space	224 square feet
	 	 	 
	Unit B1-203	Office Space	363 square feet
	 	 	 
	Unit B1-300	Office Space	906 square feet
	 	 	 
	Unit B1-400	Office Space	(included in A1-200)
	 	 	 
	Unit A2-101	Office Space	253 square feet
	 	 	 
	Unit A2-104	Office Space	216 square feet
	 	 	 
	Unit A2-105	Office Space	161 square feet
	 	 	 
	Unit A2-108	Office Space	215 square feet
	 	 	 
	Unit A2-301	Office Space	325 square feet
	 	 	 
	Unit A2-304	Office Space	216 square feet
	 	 	 
	Unit A2-305	Office Space	161 square feet
	 	 	 
	Unit B2-300	Office Space	149 square feet
	 	 	 
	Unit B2-400	Office Space	1,513 square feet
	 	 	 
	Unit B2-500	Office Space	148 square feet
	 	 	 
	Unit B2-603	Office Space	253 square feet
	 	 	 
	Unit B2-700	Office Space	148 square feet
	 	 	 
	Unit B2-900	Office Space	149 square feet


 


Total Office Space          16,724


 






    	 	— 14 —	 



     


    

 


	Unit A1-100	Lab Space	4,069 square feet
	 	 	 
	Unit B1-500	Lab Space	690 square feet
	 	 	 
	Unit A2-102	Lab Space	367 square feet
	 	 	 
	Unit A2-103	Lab Space	325 square feet
	 	 	 
	Unit A2-106	Lab Space	495 square feet
	 	 	 
	Unit A2-107	Lab Space	477 square feet
	 	 	 
	Unit A2-302	Lab Space	339 square feet
	 	 	 
	Unit A2-303	Lab Space	409 square feet
	 	 	 
	Unit B2-300	Lab Space	379 square feet
	 	 	 
	Unit B2-500	Lab Space	380 square feet
	 	 	 
	Unit B2-700	Lab Space	378 square feet
	 	 	 
	Unit B2-900	Lab Space	379 square feet


 


Total Lab Space          8,687


 




    	 	— 15 —	 



     


    

 


	FIRST FLOOR	 	SECOND FLOOR
	 	 	 


 




    	 	— 16 —	 



     


    

 


EXHIBIT B


 


 


 


PURDUE RESEARCH PARK
DEVELOPMENT POLICY


 


The Purdue Research Park was established to
create an environment in which private business and industry could interact with Purdue University for mutual benefit. The intent
of this policy statement is to identify how the Purdue Research Park can foster positive interactions between the University and
its business and industrial partners. The Research Park is an area where the environment exists to facilitate these positive partnerships.


 


Following are some general policy statements
that will serve as guidelines concerning the suitability of a particular business or industry for location in the Research Park:


 


1. The business or industry will preferably
have a technical aspect to its character that will suggest an important relationship with one or more University academic units.


 


2. Limited manufacturing activities are permitted,
but there should be a strong technical component to the company’s activity. Examples of such components are: product design,
advanced engineering, research and development, and advanced manufacturing technology. One or more of these activities should take
place on the company’s Research Park site.


 


3. Research interaction between the company
and the University should be a fundamental part of the company’s strategy. Evidence of this strategy could be a history of
past interactions, a dedicated area in the facility plans for a research activity, or a written plan with specific topics outlined
for joint research projects between the company and the University.


 


4. Internships, co-op student program, and on-site
faculty and graduate student research should be encouraged by the company. In addition, the company should be willing to permit
academically qualified staff to serve as adjunct faculty at the University.


 


5. The company should plan to utilize esoteric
University facilities in their technical activities. For example, utilization of the University’s library or computer facilities
might be a part of the company strategy.


 


6. The physical facilities that the company
plans to construct in the Research Park should be commensurate with those of a technically advanced organization. A Purdue Research
Foundation committee shall review building plans to determine if the spirit of this policy has been fulfilled.


 


7. The Purdue Research Foundation views the
companies in the Research Park as partners in a project to develop a technologically advanced community. Therefore, each project
will be considered to be a part of a long-term commitment on the part of the company and the Foundation. The Foundation will assist
potential residents of the Park in developing their plans and choosing the best site that fits the mutual interests of the company
and the Foundation.


 




    	 	— 17 —	 



     


    

 


The primary reason for a company to be located
in the Purdue Research Park is to be located near and associated with Purdue University. This proximity to Purdue University implies
a strong partnership with that institution. That principle shall underlie all the planning and discussion that occurs between the
Purdue Research Foundation and a potential resident of the Park.


 




    	 	— 18 —	 



     


    

 


EXHIBIT C


 


PURDUE TECHNOLOGY CENTER



3000
Kent Avenue



West
Lafayette, Indiana 47906


 


EXTENSION OF LEASE


 


THIS EXTENSION OF LEASE
is made this _____ day of _____________, 20___ by and between PURDUE RESEARCH FOUNDATION (“Landlord”), an Indiana corporation
(formed and existing under the Indiana Foundation or Holding Companies Act, Acts of 1921, ch. 246), and ENDOCYTE (“Tenant”).
Landlord and Tenant have previously entered into a lease (the “Lease”) dated _________, ________, for Units A1-100,
A1-200, B1-008, B1-100A, B1-200, B1-300, B1-400, B1-500, A2-100, A2-300, B2-300, B2-400, B2-500, B2-603, B2-700 AND B2-900
at the Purdue Technology Center, located at 3000 Kent Avenue, West Lafayette, IN.


 


In consideration of mutual benefits to be
derived by the parties, it is agreed that the Lease Term provided under the Lease is hereby extended for a period of __________
(_____) months, commencing _________, 20___, and expiring _____________, ____ (the “Extension Period”). All other terms
and conditions of the Lease shall be applicable to such Extension Period(s), except as follows:


 


1.          The
Monthly Rent Installment shall be __________ ($___ x _____ square feet / 12 months) and shall remain in effect during the Extension
Period unless otherwise altered under the provisions of Section 4 of the Lease.


 


2.          The
Rent shall be _________ ($___ x _____ months) and shall remain in effect during the Extension Period unless otherwise altered under
the provisions of Section 4 of the Lease.


 


It is further agreed that all other terms
and conditions of the Lease are hereby affirmed and shall remain in full force and effect during the Extension Period.


 


WITNESS the signatures and seals of the
above parties as of the day and year first above written.


 


	LANDLORD:	PURDUE RESEARCH FOUNDATION
	 	 
	 	an Indiana corporation (formed and existing under the Indiana Foundation or Holding Companies Act, Acts of 1921, ch. 246)


 


	 	By:	DRAFT
	 	 	David L. Hodde
	 	 	Assistant Vice President
	 	 	Director of Real Estate 


 




    	 	— 19 —	 



     


    

 


	ATTEST:	 
	 	 
	By:	DRAFT	 
	 	Jan H. Mills	 
	 	Director of Economic Development	 


 


	TENANT:	ENDOCYTE
	 	 
	 	By:	DRAFT	 
	 	 	P. Ron Ellis	 
	 	 	President and CEO	 


 




    	 	— 20 —