| Delaware                                                       | 777 Old Saw Mill River RoadTarrytown, New York 10591 | 13-3379479                          |
|----------------------------------------------------------------|------------------------------------------------------|-------------------------------------|
| (State or other jurisdiction of incorporation or organization) | (Address of Principal Executive Offices) (Zip Code)  | (I.R.S. EmployerIdentification No.) |
| Large accelerated filer   ̈                                             | Accelerated filer  x              |
|---------------------------------------------------------------------------------------|---------------------------------------------|
| Non-accelerated filer   ̈ (Do not check if a smaller reporting company) | Smaller reporting company   ̈ |
| Title of securitiesto be registered       |   | Amountto be registered(1) |      |   | Proposed maximumoffering priceper share(2) |   |   | Proposed maximumaggregate offeringprice(2) |   |   | Amount ofregistration fee |   |
|-------------------------------------------|--------|---------------------------|-----------|--------|--------------------------------------------|--------|--------|--------------------------------------------|--------|--------|---------------------------|--------|
| Common Stock, $0.0013 par value per share |   |                      | 3,000,000 |   |                                       | $      | 4.25   |                                       |   | $      | 12,750,000                |   |   | $ | 1,642.20 |   |
| (1) | Plus such additional shares as may be issued by reason of stock splits, stock dividends or similar transactions.                                                                                                                                       |
|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| (2) | Pursuant to Rule 457(c) and (h), estimated solely for the purpose of calculating the registration fee and are based upon the average of the high and low sales prices of the Registrant's common stock on the Nasdaq National Market on June 24, 2014. |

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|   | (a) | Annual Report on Form 10-K for the year ended December 31, 2013; |
|--------|-----|------------------------------------------------------------------|
|   | (b) | Quarterly Report on Form 10-Q for the period ended March 31, 2014; |
|--------|-----|--------------------------------------------------------------------|
|   | (c) | Current Reports on Form 8-K filed on January 24, 29 (two filings) and 30; February 6 (two filings), 20 (two filings), 21 and 26; March 4 and 13; April 2, 8, 23 and 24; May 9, 21 and 30; and June 3, 10, 11, 12 (two filings) and 18, 2014; |
|--------|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|   | (d) | The description of the Company's Common Stock in its Registration Statement on Form 8-A, dated September 29, 1997, pursuant to Section 12 of the U.S. Securities Exchange Act of 1934, as amended, including any amendments or reports filed for the purpose of updating such description. |
|--------|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

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|  | ExhibitNumber | Description                                           |
|--|---------------|-------------------------------------------------------|
|  |          |                                             |
|  | 5.1           | Opinion and Consent of David E. Martin.               |
|  |          |                                             |
|  | 10.1          | 2005 Stock Incentive Plan, as amended to date.        |
|  |          |                                             |
|  | 23.1          | Consent of David E. Martin (included in Exhibit 5.1). |
|  |          |                                             |
|  | 23.2          | Consent of Ernst & Young LLP.                     |
|  |          |                                             |
|  | 23.3          | Consent of PricewaterhouseCoopers LLP.                |
|  |          |                                             |
|  | 24.1          | Power of Attorney (included in Signature Page).       |

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|   |   | PROGENICS PHARMACEUTICALS, INC. |
|--------|--------|---------------------------------|
|   |   | By: /s/ Mark R. Baker           |
|   |   | Mark R. Baker                   |
|   |   | Chief Executive Officer         |
| /s/ Peter J. CrowleyPeter J. Crowley             | Chairman                                                                             |   | June 27, 2014 |
|--------------------------------------------------|--------------------------------------------------------------------------------------|--------|---------------|
|                                             |                                                                                 |   |          |
| /s/ Mark R. BakerMark R. Baker                   | Chief Executive Officer and Director (Principal Executive Officer)                   |   | June 27, 2014 |
|                                             |                                                                                 |   |          |
| /s/ Angelo W. Lovallo, Jr.Angelo W. Lovallo, Jr. | Vice President, Finance & Treasurer (Principal Financial and Accounting Officer) |   | June 27, 2014 |
|                                             |                                                                                 |   |          |
| /s/ Paul J. MaddonPaul J. Maddon                 | Vice Chairman                                                                        |   | June 27, 2014 |
|                                             |                                                                                 |   |          |
| /s/Karen J. FerranteKaren J. Ferrante            | Director                                                                             |   | June 27, 2014 |
|                                             |                                                                                 |   |          |
| /s/ Michael D. KishbauchMichael D. Kishbauch     | Director                                                                             |   | June 27, 2014 |
|                                             |                                                                                 |   |          |
| /s/ David A. ScheinbergDavid A. Scheinberg       | Director                                                                             |   | June 27, 2014 |
|                                             |                                                                                 |   |          |
| /s/ Nicole S. Williams                           | Director                                                                             |   | June 27, 2014 |
| Nicole S. Williams                               |                                                                                 |   |          |