Rimsulfuron Dietary Exposure and Risk Assessment DP Number: 394 389 PC Code: 129009

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### UNITED STATES ENVIRONMEN TAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION



### MEMORANDUM

Date: October 28, 2011

SUBJECT: Rimsulfuron Chronic Aggregate Dietary (Food and Drinking Water) Exposure and Risk Assessment for the Section 3 Registration on Caneberry, Bushberry, and Chicory

PC Code: 129009 DP Barcode: D394389 Decision No: 442470 Registration No: 352-768 Petition Nos.: 0E7809 Regulatory Ac tion: Section 3 Registration Risk Assess Type: None Case No.: None TXR No.: None CA S No.: 122931-48-0 MRID No.: None 40 CFR: 180.478

FROM: Elizabeth Holman, Chemist Risk Assessment Branch II, H ealth Effects Division (7509P)

THROUGH: Mohsen Sahafeyan, Chemist Amelia Acierto, Chemist Dietary Exposure Science Advisory Council Health Effects Division (7509P) and Richard Loranger, Ph.D., Branch Senior Scientist Risk Assessment Branch II (RAB2) Health Effects Division (HED; 7509P)

TO: Sidney Jackson/Barbara Madden, RM 05 Risk Integration, Minor Use, and Emergency Response Branch Registration Division (RD; 7505P)Rimsulfuron Dietary Exposure and Risk Assessment DP Number: 394 389 PC Code: 129009

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### Executive Summary

A chronic aggregate dietary (food and drinki ng water) exposure and risk assessment was conducted for the herbicide, rimsulfuron, using the Dietary Exposure Evaluation Model, DEEMFCIDTM, Version 2.03, which uses food consump tion data from the U.S. Department of Agriculture’s Continuing Surveys of Food Inta kes by Individuals (CSFII). The surveys were taken from 1994-1996 and included a supplementa l children’s survey taken in 1998. The analysis was performed to support Section 3 re gistration on caneberry, bushberry, and chicory. An acute dietary assessment was not performed, as a toxicological endpoint attributable to a single dose has not been identified for rimsulfuron. Rimsulfuron is classified as “not likely” to be carcinogenic; therefore, a cance r assessment was not performed.

The unrefined chronic assessmen t is based on the assumption th at rimsulfuron residues are present at tolerance levels in all commodities for which tolerances have been established and that 100% of those crops are treated. DEEMTM Versi on 7.81 default processing factors were applied to all processed commodities for which they were available. Drinking water was incorporated directly into the dietary assessment using the estimated drinking water concentration (EDWC) for surface water generated by the Tier 1 FQPA I ndex Reservoir Screening Tool (FIRST) Model.

The resulting chronic dietary exposure estimate s for food and water combined are well below HED’s level of concern for the general U.S. population and all populati on subgroups. Using the DEEM-FCID software, dietary exposure is estimated at 0.000428 mg/kg/day for the U.S. population (<1% of the chronic population adjusted dose (cPAD)) and 0.001063 mg/kg/day (<1% of the cPAD) for children 1 to 2 year s old, the population subgroup with the highest estimated chronic dietary e xposure to rimsulfuron.

I. Introduction

Dietary risk assessment incorporat es both exposure and toxicity of a given pesticide. For acute and chronic assessments, the risk is expresse d as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). This dose is referred to as the population adjust ed dose (PAD). The PAD is equivalent to the point of departure (PoD; e.g. NOAEL, LOAEL, et c.) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD. References which discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticid es website: “Available Information on Assessing Exposure from Pesticides, A User’s Guide,” 21-JUN-2000, web link: http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf ; or see SOP 99.6 (20- AUG-1999).Rimsulfuron Dietary Exposure and Risk Assessment DP Number: 394 389 PC Code: 129009

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### II. Residue Information

Residues of Concern: The nature of the residue of rimsul furon in plants and livestock has been adequately delineated based on metabolism studies conducted with rimsulfuron in field corn, potatoes, tomatoes, lactating goa ts, and laying hens. The metabolic pathways were found to be similar in plants and livestock. The major rout e of rimsulfuron metabol ism/degradation involves sulfonylurea bridge contraction, wi th sulfonylurea bridge cleavage as a minor metabolic route. Based on the results of the studies, HED conclude d that the residue of concern in plant and livestock commodities is rimsulfuron onl y (Memo, D360852, D. Rate, 8/13/2009, and MARC report, 2/11/98).

Tolerances: Permanent tolerances ha ve been established under 40 CFR §180.478(a) for residues of rimsulfuron at 0.01 ppm for citrus fruit, pom e fruit, stone fruit, grapes, tree nuts, and pistachios; 0.05 ppm for tomato es, 0.09 ppm for almond hulls, and 0.1 ppm for potatoes and field corn grain, forage, and stover.

DuPont Corporation has proposed tolerances for re sidues of rimsulfuron in connection with uses on caneberry, blueberry, and chicory. HED has reviewed residue data submitted for caneberry and blueberry to support these uses and conclude d that the tolerances given in Table 1 are appropriate (E. Holman, D356812, Sept. 2011). The chicory residue data and requested tolerance will be reviewed under th e forthcoming review (D391764).

Table 1. Rimsulfuron Recommended Tolerances

Crop Commodity Recommended Tolerance (ppm)

Caneberry, subgroup 13-07A 0.01 Bushberry, subgroup 13-07B 0.01 Chicory, roots 0.01 Chicory, tops 0.01

Residue Data used for the Chronic Assessment: The unrefined chronic dietary assessment is based on the assumption that rimsulfuron residue s are present at tolerance levels in all commodities for which tolerances have been es tablished and that 100% of those crops are treated. DEEMTM Version 7.81 default processing factors were applied to all processed commodities for which they were available. In the processing study for soybean oil, residues did not concentrate. Therefore, the processing factor was left at 1.0. For the commodities currently under review, there are no associated processed commodities in which residues are expected to

concentrate.

III. Drinking Water Data

The drinking water residues used in the dietary risk assessment were previously provided by the Environmental Fate and Effects Division (E FED, Memo, J. Melendez, D358869, 1/23/2009).Rimsulfuron Dietary Exposure and Risk Assessment DP Number: 394 389 PC Code: 129009

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### Water residues were incorporated directly into the DEEM-FCID assessment under the food categories “water, direct, all sources” a nd “water, indirect, all sources.”

The residue of concern in drinking water is parent rimsulfuron only (HED MARC decision memo; 03/29/1994). EFED estimated residues of rimsulfuron in surface water and groundwater using the FIRST and SCIGROW (Screening Concentrations in Groundwater) models, respectively. The models and their descriptions are available at the EPA internet site: http://www.epa.gov/oppefed1/models/water/ . The maximum estimated drinking water concentrations (EDWCs) are presented below in Table 2.

Table 2. Maximum Rimsulfuron ED WCs in Surface and Ground Water Maximum Surface Water EDWC (ppb) Maximum Ground Water Acute/Chronic EDWC (ppb) Acute Value Chronic/Cancer Value
5.596 0.120 0.016



### The chronic surface water EDWC was higher th an the groundwater EDWC; therefore, the surface water value of 0.120 ppb was used in the ch ronic dietary assessment. The acute surface water value is not relevant to th is dietary assessment, as a toxic effect attributable to a single dose has not been identified for rimsulfuron.

IV. DEEM-FCIDTM Program and Consumption Information

A rimsulfuron chronic dietary exposure assessm ent was conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Da tabase DEEM-FCIDTM, Version 2.03, which incorporates consumption data from USDA’s Continuing Su rveys of Food Intakes by Individuals (CSFII), 1994-1996 and 1998. The 1994-96, 98 data are based on the reported consumption of more than 20,000 in dividuals over two non-consecuti ve survey days. Foods “as consumed” (e.g., apple pie) are linked to EPA- defined food commodities (e.g. apples, peeled fruit - cooked; fresh or N/S; baked; or wheat fl our - cooked; fresh or N/ S, baked) using publicly available recipe translation files develope d jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups, but for acute exposure assessm ent are retained as individual consumption events. Based on analysis of the 1994-96, 98 C SFII consumption data, which took into account dietary patterns and survey respondents, HED concl uded that it is most appr opriate to report risk for the following population subgroups: the genera l U.S. population, all infants (<1 year old), children 1-2, children 3-5, ch ildren 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50+ years old.

For chronic dietary exposure assessment, an esti mate of the residue level in each food or foodform (e.g., orange or orange juice) on the f ood commodity residue list is multiplied by the average daily consumption estimate for that food/f ood form to produce a residue intake estimate. The resulting residue intake estimate for each f ood/food form is summed w ith the residue intake estimates for all other food/food forms on the comm odity residue list to arrive at the total average estimated exposure. Exposure is expres sed in mg/kg body weight/day and as a percent of the cPAD. This procedure is performed for each population subgroup.Rimsulfuron Dietary Exposure and Risk Assessment DP Number: 394 389 PC Code: 129009

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### V. Toxicological Information

Reference: Rimsulfuron – Updated Executive Su mmaries and Section 4.0 of Risk Assessment Document for Registration Action Branch 2., E. Rinde, TXR Num. 0054356, 09/27/2006.

HED has evaluated the available toxicity data fo r rimsulfuron and determined that the following endpoints and doses are appropriate for use in the dietary risk assessment:

Table 3. Summary of Toxicological Doses and En dpoints for Rimsulfuron fo r Use in Human Dietary Risk Assessments

Exposure Scenario Point of Departure/Uncertainty,

FQPA Safety Factors RfD, PAD, Level of Concern Study and Toxicological Effects

Acute Dietary (females 13-49) Acute Dietary (general population) None No appropriate endpoint attributable to a single dose is available.

Chronic Dietary (all populations) NOAEL=11.8 mg/kg/day

UF A = 10X
UF H = 10X FQPA SF = 1X cPAD = 0.118 mg/kg/day Combined Chronic/CarcinogenicityRat LOAEL= 121 mg/kg/day in males; 568 mg/kg/day in females (NOAEL=163 mg/kg/day), based on decreased body weight gains and liver effects.
Cancer (oral, dermal, inhalation) Classification:

Rimsulfuron is classified as a “ not likely “human carcinogen.
Point of Departure (PoD) = A data point or an estimated point that is derived from observed dose-response data and used to mark the beginning of extrapolation to determine risk associated with lower en vironmentally relevant human exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UF A = extrapolation from animal to human (interspecies). UF H = potential variation in sensitivity among members of the human population (intra species). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic).



### The FQPA Safety Factor has been reduced to 1x for all population subgroups, as there are no residual uncertainties, and there is no evidence of increased pr e- and/or post-natal susceptibility to rimsulfuron. There is no evidence of neur otoxicity in the database, and a developmental neurotoxicity (DNT) study has not been required.

VI. Results/Discussion

As stated above, for chronic assessments, HED is concerned when dietary risk exceeds 100% of the cPAD. The DEEM-FCIDTM analyses estimate the dietary exposure of the U.S. population and various population subgroups. The results re ported in Table 3 are for the general U.S. Population, all infants (<1 year old), child ren 1-2, children 3-5, ch ildren 6-12, youth 13-19, females 13-49, adults 20-49, and adults 50+ years.Rimsulfuron Dietary Exposure and Risk Assessment DP Number: 394 389 PC Code: 129009

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### Rimsulfuron chronic dietary (food + water) e xposure estimates us ing the DEEM-FCIDTM software are well below HED’s level of con cern for the U.S. population and each of the population subgroups. Dietary ex posure was estimated to be 0.000428 mg/kg/day for the U.S. population (<1% of the cPAD) and 0.001063 mg/kg/da y (<1% of the cPAD) for the most highly exposed population subgroup (children, 1-2 years ol d). The estimated exposures and risks from residues of rimsulfuron in food and water are summarized in Table 4.

Table 4. Chronic Aggregate Dietary (Food + Dri nking Water) Exposure and Risk for Rimsulfuron

Population Subgroup Exposure (mg/kg/day) % cPAD

General U.S. Population 0.000428 <1

All Infants (< 1 year old) 0.000544 <1

Children 1-2 years old 0.001063 <1

Children 3-5 years old 0.001003 <1

Children 6-12 years old 0.000686 <1

Youth 13-19 years old 0.000504 <1

Adults 20-49 years old 0.000342 <1

Adults 50+ years old 0.000254 <1

Females 13-49 years old 0.000337 <1

1 The population subgroup with the highest estimated chronic dietary (food + drinking water) exposure and risk is indicated by bold text.



### VII. Characterization of Inputs/Outputs

These chronic dietary exposure and risk estimate s are highly conservative. They are based on the assumption that 100% of crops with tolerances are tr eated with rimsulfuron, and that residues in foods “as eaten” are present at tolerance leve ls. In addition, drinking water exposure estimates are screening level estimates genera ted by the Tier 1 FIRST Model.

Dietary exposure estimates could be refined through the use of an ticipated residues, percent crop treated data, and/or refined es timated drinking water concentra tions. However, as estimated exposures and risks using conserva tive assumptions are well belo w HED’s level of concern, such refinement is not warranted.

VIII. Conclusions

This unrefined chronic dietary exposure analys is using DEEM-FCIDTM indicates that chronic dietary exposure to rimsulfur on from food and drinking water is well below HED’s level ofRimsulfuron Dietary Exposure and Risk Assessment DP Number: 394 389 PC Code: 129009

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### concern for this pesticide. Estimated chronic di etary exposures are less th an 1% of the cPAD for the general U.S. population and all population subgroups.

IX. List of Attachments

1. Rimsulfuron Chronic Diet ary Residue Input File 2. Results of Rimsulfuron Chr onic Dietary Exposure AnalysisRimsulfuron Dietary Exposure and Risk Assessment DP Number: 394 389 PC Code: 129009

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### Attachment 1: Rimsulfuron Chr onic Dietary Residue Input File

Filename: F:\Rimsulfuron\Rimsulfuron Chronic2011.R98 Chemical: Rimsulfuron RfD(Chronic): .118 mg/kg bw/day NOEL(Chronic): 11.8 mg/kg bw/day RfD(Acute): 0 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Date created/last modified: 09-16-2011/14:37:59/8 Program ver. 2.03 Comment: Tier 1 Chronic Aggregate (Food + Drinking Water) Dietary Assessment.

-------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

-------- ---- ------------------------------- ---------- ------ ------ ------- 95001750 O Grape 0.010000 1.000 1.000 95001760 O Grape, juice 0.010000 1.200 1.000 95001761 O Grape, juice-babyfood 0.010000 1.200 1.000 95001770 O Grape, leaves 0.010000 1.000 1.000 95001780 O Grape, raisin 0.010000 4.300 1.000 95001790 O Grape, wine and sherry 0.010000 1.000 1.000 86010000 O Water, direct, all sources 0.000120 1.000 1.000 86020000 O Water, indirect, all sources 0.000120 1.000 1.000 01011000 1AB Chicory, roots 0.010000 1.000 1.000 01032960 1C Potato, chips 0.100000 1.000 1.000 01032970 1C Potato, dry (granules/ flakes) 0.100000 6.500 1.000 01032971 1C Potato, dry (granules/ flakes)-b 0.100000 6.500 1.000 01032980 1C Potato, flour 0.100000 6.500 1.000 01032981 1C Potato, flour-babyfood 0.100000 6.500 1.000 01032990 1C Potato, tuber, w/peel 0.100000 1.000 1.000 01032991 1C Potato, tuber, w/peel-babyfood 0.100000 1.000 1.000 01033000 1C Potato, tuber, w/o peel 0.100000 1.000 1.000 01033001 1C Potato, tuber, w/o peel-babyfood 0.100000 1.000 1.000 02001010 2 Chicory, tops 0.010000 1.000 1.000 06003470 6 Soybean, seed 0.010000 1.000 1.000 06003480 6 Soybean, flour 0.010000 1.000 1.000 06003481 6 Soybean, flour-babyfood 0.010000 1.000 1.000 06003490 6 Soybean, soy milk 0.010000 1.000 1.000 06003491 6 Soybean, soy milk-babyfood or in 0.010000 1.000 1.000 06003500 6 Soybean, oil 0.010000 1.000 1.000 06003501 6 Soybean, oil-babyfood 0.010000 1.000 1.000 08003740 8 Tomatillo 0.050000 1.000 1.000
08003750 8 Tomato 0.050000 1.000 1.000 08003751 8 Tomato-babyfood 0.050000 1.000 1.000 08003760 8 Tomato, paste 0.050000 5.400 1.000 08003761 8 Tomato, paste-babyfood 0.050000 5.400 1.000 08003770 8 Tomato, puree 0.050000 3.300 1.000 08003771 8 Tomato, puree-babyfood 0.050000 3.300 1.000 08003780 8 Tomato, dried 0.050000 14.300 1.000 08003781 8 Tomato, dried-babyfood 0.050000 14.300 1.000 08003790 8 Tomato, juice 0.050000 1.500 1.000 10001060 10 Citrus citron 0.010000 1.000 1.000 10001070 10 Citrus hybrids 0.010000 1.000 1.000 10001080 10 Citrus, oil 0.010000 1.000 1.000 10001800 10 Grapefruit 0.010000 1.000 1.000 10001810 10 Grapefruit, juice 0.010000 2.100 1.000 10001970 10 Kumquat 0.010000 1.000 1.000
10001990 10 Lemon 0.010000 1.000 1.000 10002000 10 Lemon, juice 0.010000 2.000 1.000 10002001 10 Lemon, juice-babyfood 0.010000 2.000 1.000 10002010 10 Lemon, peel 0.010000 1.000 1.000 10002060 10 Lime 0.010000 1.000 1.000 10002070 10 Lime, juice 0.010000 2.000 1.000 10002071 10 Lime, juice-babyfood 0.010000 2.000 1.000 10002400 10 Orange 0.010000 1.000 1.000 10002410 10 Orange, juice 0.010000 1.800 1.000 10002411 10 Orange, juice-babyfood 0.010000 1.800 1.000 10002420 10 Orange, peel 0.010000 1.000 1.000
10003070 10 Pummelo 0.010000 1.000 1.000Rimsulfuron Dietary Exposure and Risk Assessment DP Number: 394 389 PC Code: 129009

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Page 9 of 12 10003690 10 Tangerine 0.010000 1.000 1.000 10003700 10 Tangerine, juice 0.010000 2.300 1.000 11000070 11 Apple, fruit with peel 0.010000 1.000 1.000 11000080 11 Apple, peeled fruit 0.010000 1.000 1.000 11000081 11 Apple, peeled fruit-babyfood 0.010000 1.000 1.000 11000090 11 Apple, dried 0.010000 8.000 1.000 11000091 11 Apple, dried-babyfood 0.010000 8.000 1.000 11000100 11 Apple, juice 0.010000 1.300 1.000 11000101 11 Apple, juice-babyfood 0.010000 1.300 1.000 11000110 11 Apple, sauce 0.010000 1.000 1.000 11000111 11 Apple, sauce-babyfood 0.010000 1.000 1.000 11001290 11 Crabapple 0.010000 1.000 1.000 11002100 11 Loquat 0.010000 1.000 1.000
11002660 11 Pear 0.010000 1.000 1.000 11002661 11 Pear-babyfood 0.010000 1.000 1.000 11002670 11 Pear, dried 0.010000 6.250 1.000 11002680 11 Pear, juice 0.010000 1.000 1.000 11002681 11 Pear, juice-babyfood 0.010000 1.000 1.000 11003100 11 Quince 0.010000 1.000 1.000 12000120 12 Apricot 0.010000 1.000 1.000 12000121 12 Apricot-babyfood 0.010000 1.000 1.000 12000130 12 Apricot, dried 0.010000 6.000 1.000 12000140 12 Apricot, juice 0.010000 1.000 1.000 12000141 12 Apricot, juice-babyfood 0.010000 1.000 1.000 12000900 12 Cherry 0.010000 1.000 1.000 12000901 12 Cherry-babyfood 0.010000 1.000 1.000 12000910 12 Cherry, juice 0.010000 1.500 1.000 12000911 12 Cherry, juice-babyfood 0.010000 1.500 1.000 12002300 12 Nectarine 0.010000 1.000 1.000
12002600 12 Peach 0.010000 1.000 1.000 12002601 12 Peach-babyfood 0.010000 1.000 1.000 12002610 12 Peach, dried 0.010000 7.000 1.000 12002611 12 Peach, dried-babyfood 0.010000 7.000 1.000 12002620 12 Peach, juice 0.010000 1.000 1.000 12002621 12 Peach, juice-babyfood 0.010000 1.000 1.000
12002850 12 Plum 0.010000 1.000 1.000 12002851 12 Plum-babyfood 0.010000 1.000 1.000 12002860 12 Plum, prune, fresh 0.010000 1.000 1.000 12002861 12 Plum, prune, fresh-babyfood 0.010000 1.000 1.000 12002870 12 Plum, prune, dried 0.010000 5.000 1.000 12002871 12 Plum, prune, dried-babyfood 0.010000 5.000 1.000 12002880 12 Plum, prune, juice 0.010000 1.400 1.000 12002881 12 Plum, prune, juice-babyfood 0.010000 1.400 1.000 13010550 13A Blackberry 0.010000 1.000 1.000 13010560 13A Blackberry, juice 0.010000 1.000 1.000 13010561 13A Blackberry, juice-babyfood 0.010000 1.000 1.000 13020570 13B Blueberry 0.010000 1.000 1.000 13020571 13B Blueberry-babyfood 0.010000 1.000 1.000 13010580 13A Boysenberry 0.010000 1.000 1.000
13021360 13B Currant 0.010000 1.000 1.000 13021370 13B Currant, dried 0.010000 1.000 1.000 13011420 13A Dewberry 0.010000 1.000 1.000 13021490 13B Elderberry 0.010000 1.000 1.000 13021740 13B Gooseberry 0.010000 1.000 1.000 13021910 13B Huckleberry 0.010000 1.000 1.000 13012080 13A Loganberry 0.010000 1.000 1.000 13013200 13A Raspberry 0.010000 1.000 1.000 13013201 13A Raspberry-babyfood 0.010000 1.000 1.000 13013210 13A Raspberry, juice 0.010000 1.000 1.000 13013211 13A Raspberry, juice-babyfood 0.010000 1.000 1.000
14000030 14 Almond 0.010000 1.000 1.000 14000031 14 Almond-babyfood 0.010000 1.000 1.000 14000040 14 Almond, oil 0.010000 1.000 1.000 14000041 14 Almond, oil-babyfood 0.010000 1.000 1.000 14000590 14 Brazil nut 0.010000 1.000 1.000
14000680 14 Butternut 0.010000 1.000 1.000Rimsulfuron Dietary Exposure and Risk Assessment DP Number: 394 389 PC Code: 129009

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Page 10 of 12 14000810 14 Cashew 0.010000 1.000 1.000
14000920 14 Chestnut 0.010000 1.000 1.000 14001550 14 Filbert 0.010000 1.000 1.000 14001560 14 Filbert, oil 0.010000 1.000 1.000 14001850 14 Hickory nut 0.010000 1.000 1.000 14002130 14 Macadamia nut 0.010000 1.000 1.000
14002690 14 Pecan 0.010000 1.000 1.000 14002820 14 Pistachio 0.010000 1.000 1.000
14003910 14 Walnut 0.010000 1.000 1.000 15001200 15 Corn, field, flour 0.100000 1.000 1.000 15001201 15 Corn, field, flour-babyfood 0.100000 1.000 1.000 15001210 15 Corn, field, meal 0.100000 1.000 1.000 15001211 15 Corn, field, meal-babyfood 0.100000 1.000 1.000 15001220 15 Corn, field, bran 0.100000 1.000 1.000 15001230 15 Corn, field, starch 0.100000 1.000 1.000 15001231 15 Corn, field, starch-babyfood 0.100000 1.000 1.000 15001240 15 Corn, field, syrup 0.100000 1.500 1.000 15001241 15 Corn, field, syrup-babyfood 0.100000 1.500 1.000 15001250 15 Corn, field, oil 0.100000 1.000 1.000 15001251 15 Corn, field, oil-babyfood 0.100000 1.000 1.000Rimsulfuron Dietary Exposure and Risk Assessment DP Number: 394 389 PC Code: 129009

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### Attachment 2: Results of Rimsulfu ron Chronic Dietary Exposure Analysis

U.S. Environmental Protection Agency Ver.
2.00 DEEM-FCID Chronic analysis for RIMSULFURON (1994-98 data) Residue file name: F:\Rimsulfuron\Rimsulfuron Chronic2011.R98 Adjustment factor #2 NOT
used. Analysis Date 09-16-2011/14:38:31 Residue file dated: 09-16- 2011/14:37:59/8 Reference dose (RfD, Chronic) = .118 mg/kg bw/day COMMENT 1: Tier 1 Chronic Aggregate (Food + Drinking Water) Dietary

Assessment.

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===== Total exposure by population subgroup

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Total Exposure

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-- Population mg/kg Percent of Subgroup body wt/day Rfd

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-- U.S. Population (total) 0.000428 0.4%

U.S. Population (spring season) 0.000429 0.4% U.S. Population (summer season) 0.000434 0.4% U.S. Population (autumn season) 0.000423 0.4% U.S. Population (winter season) 0.000427 0.4%

Northeast region 0.000405 0.3% Midwest region 0.000459 0.4% Southern region 0.000422 0.4% Western region 0.000427 0.4%

Hispanics 0.000493 0.4% Non-hispanic whites 0.000417 0.4% Non-hispanic blacks 0.000446 0.4% Non-hisp/non-white/non-black 0.000401 0.3%

All infants (< 1 year) 0.000544 0.5% Nursing infants 0.000194 0.2% Non-nursing infants 0.000677 0.6% Children 1-6 yrs 0.000997 0.8% Children 7-12 yrs 0.000657 0.6%

Females 13-19 (not preg or nursing) 0.000452 0.4% Females 20+ (not preg or nursing) 0.000284 0.2% Females 13-50 yrs 0.000362 0.3%Rimsulfuron Dietary Exposure and Risk Assessment DP Number: 394 389 PC Code: 129009

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Page 12 of 12 Females 13+ (preg/not nursing) 0.000347 0.3% Females 13+ (nursing) 0.000335 0.3%

Males 13-19 yrs 0.000556 0.5% Males 20+ yrs 0.000337 0.3% Seniors 55+ 0.000250 0.2%

Children 1-2 yrs 0.001063 0.9% Children 3-5 yrs 0.001003 0.9% Children 6-12 yrs 0.000686 0.6% Youth 13-19 yrs 0.000504 0.4% Adults 20-49 yrs 0.000342 0.3% Adults 50+ yrs 0.000254 0.2% Females 13-49 yrs 0.000337 0.3%

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