Aminoethoxyvinylglycine Hydrochloride Case #: 6070

129104

Product Chemistry—Registration Review

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

July 27, 2011

OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION

MEMORANDUM

SUBJECT: Product Chemistry Scoping Document for the Registration Review of 

Aminoethoxyvinylglycine Hydrochloride. 

Registration Review Case #: 6070

PC Code: 129104 

CAS Numbers: 55720-26-8

Chemical Class: Biochemical

FROM: Jacob Moore, Chemist /s/ 07/27/2011

Biochemical Pesticides Branch

Biopesticides & Pollution Prevention Division (7511P)

TO: John Fournier, Regulatory Action Leader

Biochemical Pesticides Branch

Biopesticides & Pollution Prevention Division (7511P) 

ACTION REQUESTED

A preliminary assessment of available information on product chemistry data associated with 

the biopesticide aminoethoxyvinylglycine hydrochloride in support of the development of a 

Registration Review Work Plan.
Aminoethoxyvinylglycine Hydrochloride Case #: 6070

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Introduction

The EPA has made the determination that there is adequate information available on 

aminoethoxyvinylglycine hydrochloride, commonly known as AVG, and does not foresee the 

need to require additional data from products currently registered that contain AVG as the active 

ingredient. AVG is a plant growth regulator used on apples, pears, and ornamentals. In apples, it 

may delay fruit maturity, leading to benefits such as a reduction in pre-harvest fruit drop and 

improved fruit quality. In pears, AVG may help maintain fruit firmness. For specific ornamentals 

(miniature carnations, hibiscus, and rooted geranium cuttings and seedlings), AVG may reduce 

problems, such as flower senescence and flower bud abscission, that occur during shipping. AVG

products have been registered with the EPA since 1997. Currently there are 11 active 

registrations containing AVG, including two technical grade active ingredient registrations, six 

end-use or manufacturing-use products, and three experimental use permits. The technical 

registrations contain 86% active ingredient by weight with the balance consisting of impurities. 

The Agency exempts AVG from the requirement of a tolerance under the following conditions:

Commodity Parts Per Million

Apple 0.08

Fruit, stone, group 12, except cherry 0.170

Pear 0.08

40 CFR §180.502

Concerning the product chemistry of AVG, all biochemical pesticide data requirements for the 

technical grade active ingredient have been satisfied and are summarized in Table 2. While no 

further product chemistry data are necessary for the products currently registered, future products 

must adequately address all of the biochemical pesticides product chemistry data requirements.
Aminoethoxyvinylglycine Hydrochloride Case #: 6070

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Table 1. Product Identity and Composition for AVG

Common Name Aminoethoxyvinylglycine Hydrochloride (AVG)

Chemical Name, IUPAC (3E)-2-amino-4-(2-aminoethoxy)-3-butenoic acid

Molecular Weight 196.6 g/mol

PC Code 129104

CAS Registry Number 55720-26-8

Empirical Formula C6H13N2 O3Cl

Registration Review Case Number 6070

Chemical Structure
Aminoethoxyvinylglycine Hydrochloride Case #: 6070

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Product Chemistry Summary

The Agency has conducted a review of the available product chemistry data and information. 

These data are summarized below.

Table 2. Biochemical Pesticides Product Chemistry Data Requirements for AVG

Guideline No. Physical and Chemical 

Properties

Status1 Value

830.1100 Product Identity and 

Composition

A Refer to Table 1.

830.1200 Description of starting materials, 

production and formulation 

process

A CBI

830.1400 Discussion of formation of 

impurities

A CBI

830.1700 Preliminary analysis A CBI

830.6302 Color A Light Brown

830.6303 Physical state A Powder

830.6304 Odor A Slightly musty

830.6313 Stability to normal and elevated 

temperatures, metals and metal 

ions

N/D Stable

830.7000 pH A 6.9 (0.1% solution)

830.7050 UV/Visible light absorption

 Water ,303.0

 1N HCl/water (10/90) , 300.9

 1N NaOH/water (10/90) ,303.0

A Molar Absorptivity (ε)

41.4 ± 0.5 L mol-1cm-1

40.2 ± 0.2 L mol-1cm-1

39.8 ± 2.2 L mol-1cm-1

830.7200 Melting point/melting range A 193-195°C

830.7220 Boiling point/boiling range N/A --

830.7300 Density A 0.42 g/cm3

830.7520 Particle size, fiber length, and 

diameter distribution

N/A N/A; water soluble

830.7550

830.7560

830.7570

Partition coefficient (nOctanol/Water)A Log Pow = -4.36±0.58

830.7840 Water solubility A H2O pH 5.0 = 660 ± 39 g/L

H2O pH 6.0 = 674 ± 23 g/L

H2O pH 9.0 = 689 ± 10 g/L

830.7950 Vapor pressure A Very low; typical solid

1. A=Acceptable. N/A=Not Applicable.
Aminoethoxyvinylglycine Hydrochloride Case #: 6070

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References

Devisetty, B., Bade, T. Product Identity, Manufacturing Process, VBC-30102 (AVG HCL Liquid 

Formulation). Private Study by Valent Biosciences Corp Submitted to EPA. MRID 

477707-01. 2009.

Merck Index, Online. 07/19/2011.

PubChem. http://pubchem.ncbi.nlm.nih.gov/summary/summary.chi?cid=6434508. 07/25/2011.