Fenpyroximate Dietary Exposure and Risk Assessment DP# 405718

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### UNITED STA**TES ENVIRONMENTA L PROTECTION A**  **GENCY** WA SHINGTON, D.C. 20460 **OFFICE OF CHEMICAL SAFETY AND**  **POLLUTION PREVENTION** 

### Date: 08 - MAY - 2013 **Subject: Fenpyroximate.**  Petition for the Establishment of Permanent Tolerances for

Residues in/on Stone Fruits (Group 12 - 12), Tuberous and Corm Vegetables (Subgroup 1C), and Small Vine Climbing Fruits Except Kiwifruit (Subgroup 13 - 07F). **Acute and Chronic Dietary Exposure and Risk Assessments.**  **PC Code:** 129131 **DP Barcode:** D405 718 **Decision No.:** 468635 **Registration Nos :**  71711 - 19, 71711 - 4 **Petition No.:** 2E8072 **Regulatory Action:** Sec. 3 Registration **Risk Assessment Type:** Dietary **Case No.:** 7432 **T XR No.:**  NA **CAS No.:** 134098 - 61 - 6 (E - isomer) **MRID No.:** None **40 CFR:** §180.566 **From:** George F. Kramer, Ph.D., Senior Chemist

Risk Assessment Branch 1 (RAB1) Health Effects Division (HED; 7509P) **Through:** Julie L . Van Alstine, MPH, Enviro nmental Health Scientist

Thurston Morton, Chemist Dietary Exposure Science Advisory Council (DESAC)/HED (7509P) and Dana M. Vogel, Acting Branch Chief, RAB1 Associate Division Director, HED (7509P) **To:** Jennifer R. Tyler, Risk Assessor

RAB1/HED (7509P) and Barbara Madden/Sidney

Jackson, RM 05 Registration Division (RD; 7505P) **Executive Summary** Acute and chronic aggregate dietary (food + drinking water) exposure and risk assessments were conducted for fenp yr oximate using the Dietary Exposure Evaluation Model - Food Consumption Intake Database (DEEM - FCID, ver. 3.16) which incorporates consumption data from United States Department of Agriculture (USDA) National Health and Nutrition Examination Survey , What We Eat in America, (NHANES/WWEIA; 2003 - 2008). The anal ys es were performed to support Section 3 use requests on stone fruits (group 12 - 12), smal l vine climbing fruits except kiwifruit (subgroup 13 - 07F), and tuberous and corm vegetables (subgroup 1C) .Fenpyroximate Dietary Exposure and Risk Assessment DP# 405718

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### Acute Dietary

(Food + Drinking Water) Exposure Results and Characterization Separate acute dietary

risk anal ys es were conducted for females 13 - 49 y ears old and for the general U.S. population , as separate endpoints of concern attributable to a single dose were identified. Both acute analy ses assumed 100% crop treated (CT), tolerance - level residues for all commodities . DEEM (ver. 7.81 ) default proce ssing factors were assumed for all commodities excluding apple, pear, and grape juice (0.11x); grape, raisin (2.7x); orange, grapefruit, tangerine, lemon , and lime juice (0.06x); tomato paste (1.0x) and puree (1.0x); dried plum (1.0x); and peppermint and spearmint oil (0.08x). The acute analy ses incorporated the estimated drinking water concentrations (EDWCs) provided by Environmental Fate and Effects Div ision (EFED). An EDWC of 0.043 ppm was used in the acute analy ses, as this was the highest (i.e., most conservative) estimate. The resulting acute food plus drinking water risk estimates are not of concern to HED (<100% acute population - adjusted dose ( aPAD)) at the 95 th 

### percentile of the exposure. The resulting acute risk estimate is 13% of the aPAD at the 95 th 

### percentile of the exposure distribution for females 13 to 49 ye ars old. The highest acute exposure estimate for the U.S. population or populat ion subgroup is children 1 - 2 y ears old , which resulted in a risk estimate of 6.2% aPAD. Chronic Dietary

(Food + Drinking Water) Exposure Results and Characterization The chronic anal ys is assumed DEEM (ver. 7.81) default processing factors, 100% CT, toler ance level residues for all commodities, and DEEM (ver. 7.81) default processing factors for most commodities (see above). The chronic anal ys is also incorporated EDWCs provided b y EFED ( an EDWC of 0.0086 ppm was used in the chronic anal ys is ). The resulti ng chronic risk estimates are not of concern to HED. The most highl y exposed population was children 1 - 2 ye ars old utilizing 15% of the chronic PAD (cPAD). A chronic cancer dietary

assessment was not conducted since it was determined that fenp yroximate is not a possible human carcinogen. **I. Introduction** Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasona ble adverse health effects). This dose is referred to as the PAD. The PAD is equivalent to point of departure (POD, NOAEL, LOAE L, e.g.) divided by the required uncertaint y and/ or safet y factors. For acute and non - cancer chronic exposures, HED is concern ed when estimated dietary risk exceeds 100% of the PAD. References which discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site: “Available Information on Assessing Exposure from Pesticides, A User’s Gu ide,” 21 - JUN - 2000, web link: http://www.epa.gov/fedrgstr/EPA - PEST/2000/July /Day - 12/6061.pdf

; or see SOP 99.6 (20 - AUG 1999). The most recent dietary

risk assessment for fenp yr o ximate was conducted by S. Levy (23 - MAY 2012; DP# 391844 ).Fenpyroximate Dietary Exposure and Risk Assessment DP# 405718

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### II. Residue Information Fenp yroximate is a contact insecticide/miticide used for the control of leafhoppers, meal ybugs, and mites. Fenp yroximate is a mitochondrial electron - transport inhibitor (METI) which acts by targeting proton - translocating NADH:Q oxidoreductase and blocking ubiquinone reduction. Residues of Concern: Acceptable plant metabolism studies with fenpy roximate on apples, citrus, cotton, and grapes were previously submitted. HED has determined (Memo, J. Stokes, 12 - AUG 2003; D292639) that the residues of concern for plants for the purposes of tolerance enforcement and risk assessment are fenpy roximate 4 - [[[(

E) - [(1,3 - dimethyl - 5 - phenoxy - 1 H - py razol - 4 - yl ) methylene]amino]oxy] methyl]b enzoate plus its Z - isomer (also called metabolite M - 1 or 4 - [[[(Z ) - [(1,3 - dimethyl - 5 - phenoxy - 1 H - py razol - 4 - yl ) methylene]amino]oxy]methyl]benzoate). The nature of residue in lactating goat s is understood. The HED Metabolism Assessment Review Committee (MA RC) concluded that for milk and the fat, meat, and meat by products (excluding liver and kidney) of cattle, goat, horse, and sheep, the parent compound, and its metabolites (

E) - 4 - [(1,3 - dimethyl - 5 - phenoxy py razol - 4 - yl ) - methylene aminooxy methyl]benzoic acid an d ( E) - 1,1 - dimethylethyl - 2 - hydroxy eth yl 4 - [[[[(1,3 - dimethyl - 5 - phenoxy- 1 H - py razol - 4 - yl ) methylene] amino]oxy]methyl]benzoate, calculated as the parent compound , are the residues of concern (Memo, J. Stokes, 12 - AUG - 2003; D292639). Additionally , the residues of concern for cattle, goat, horse, and sheep liver and kidney are fenpy roximate and its metabolite ( E ) - 4 - [(1,3 - dimethyl - 5 - phenoxy

py razol - 4 - yl ) - methylene aminooxy methyl]benzoic acid, calculated as the parent compound. For drinking water, the residues of c oncern for risk assessment include the parent, M - 1 and M - 3. Established/Recommended Tolerances: Fenp yro ximate tolerances are established in 40 CFR §180.56 6. Tolerances for residues in/on plant commodities are expressed in terms of the combined residues of fenpy roximate and its Z - isomer. Permanent tolerances for residues in/on plant commodities, under §180.566(a)(1), range from 0.10 ppm to 20 ppm. Tolerances for residues in/on milk and the fat, meat, and meat b yproducts (excluding liver and kidney) of cattle, goat, horse, and sheep are listed in 40 CFR §180.566(a)(2) and are expressed in terms of the combined residues of fenpy roximate and its metabolites ( E ) - 4 - [(1,3 - dimethyl - 5 - phenoxy py razol 4 - yl ) - methylene aminooxy methyl]benzoic ac id and ( E ) - 1,1 - dimethylethyl - 2 - hydroxy eth yl 4 - [[[[(1,3 - dimethyl - 5 - phenoxy- 1 H - py razol - 4 - yl )methylene]amino]oxy]methyl]benzoate, calculated as the parent compound. Tolerances for residues in cattle, goat, horse, and sheep liver and kidney are listed under 4 0 CFR §180.566(a)(3) at 0.25 ppm and are expressed in terms fenp yroximate and its metabolite ( E) - 4 - [(1,3 - dimethyl - 5 - phenoxy py razol - 4 - yl ) - methylene aminooxy methyl]benzoic acid, calculated as the parent compound. A time - limited tolerance for residues in/on honey

at 0.10 ppm with a 12/31/13 expiration date is listed in 40 CFR §180.566(b) under a Section 18 Emergency Exemption. The Interregional Project No. 4 (IR - 4) has proposed a Section 3 Registration for application of fenp yroximate to stone fruits (grou p 12 - 12), small vine climbing fruits except kiwifruit (subgroup 13 - 07F), and tuberous and corm vegetables (subgroup 1C). IR - 4, requests the establishment of tolerances for the combined residues of the insecticide fenpy roximate in/on the following raw agri cultural commodities (RACs).Fenpyroximate Dietary Exposure and Risk Assessment DP# 405718

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Page 4 of 19 **Comm odity**  **HED -**  **Recommended Tolerance (ppm)** Fruit, stone, group 12 - 12 2.0 Vegetable, tuberous and corm, subgroup lC 0.10 Fruit, small, vine climbing, except fuzzy kiwifruit, subgroup 13 - 07F 1.0 

### No new residue data were submitted to support tolerance on small vine climbing fruits except kiwifruit (subgroup 13 - 07F) . IR - 4 has requested that the established tolerance for residues in/on grape be expanded to its respective crop group. Residues used i n the Acute and Chronic Analysis : These analy ses employ ed established and HED recommended tolerance - level residues for all commodities and DEEM (ver. 7.81) default processing factors for all commodities excluding apple, pear, and grape juice (0.11x); grap e, raisin (2.7x); orange, grapefruit, tangerine, lemon, and lime juice (0.06x); tomato paste (1.0x) and puree (1.0x); dried plum (1.0x); and peppermint and spearmint oil (0.08x). **III. EDWCs** Drinking water residues were incorporated directly into the ac ute and chronic dietary analy ses (“water, direct, all sources” and “water, indirect, all sources”) and were provided by EFED (Memo, G. Orrick, 20 - SEP - 2012; D 404840 ). The EDWCs were screening - level estimates generated with the Food Quality Protection Act (FQPA) Index Reservoir Screening Tool (FIRST) and a Provisional Cranberry Model for fenpy

roximate and its metabolites (M - 1 and M 3) in surface water and with Screening Concentration in Ground Water (SCI - GROW) for ground wat er. Although the current and proposed end - use labels that result in the highest exposure are for ornamentals (an application rate to ornamentals of 0.343 lbs ai/A with a maximum application of 0.686 lbs ai/A), the use scenario with the highest acute and c hronic EDWCs are for the cranberry

scenario (see Table 1). **Table 1. Maximum Screening EDWCs of Fenpyroximate for Current and Proposed Uses. 1**  Drinking Water Source (model) Use (Maximum Annual Rate) Upper - Bound Estimated Drinking

Water Concentrations (ppb) Ac ute (peak exposure) Chronic (annual

mean exposure) Surface Water (FIRST) Ornamentals (0.69 lb ai/A) 29 1.9 Surface Water (Cranberry model) Cranberries (0.20 lb ai/A) **43 8.6**  Groundwater (SCI - GROW) Ornamentals (0.69 lb ai/A) < 0.27 1 Maximum values in bold. 

### Surface water EDWCs of 0.043 ppm and 0.0086 ppm were used in the acute and chronic anal ys es, respectivel y, as these values were the highest and provided a more conservative approach. **IV. DEEM -**  **FCID Program and Consumption Information**  Fenp yroximate acute and chronic dietary exposure assessments were conducted using DEEM FCID (ver. 3.16) which incorporates consumption data from USDA’s NHANES/WWEIA. This dietary survey was conducted from 2003 to 2008. The data are based on the reported consumption of more than 20,000 individuals over two non - consecutive survey day s. Foods “asFenpyroximate Dietary Exposure and Risk Assessment DP# 405718

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### consumed” (e.g., apple pie) are linked to EPA - defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicl y available recipe translation files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups. Based on anal ys is of the 2003 - 2008 WWEIA consumption data, which took into account dietary

patterns and survey

respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all in fants (<1 ye ar old), children 1 - 2, children 3 - 5, children 6 - 12, youth 13 - 19, adults 20 - 49, females 13 - 49, and adults 50 - 99 y ears old. For chronic dietary

exposure assessment, an estimate of the residue level in each food or food form (e.g., orange or oran ge juice) on the food commodity residue list is multiplied by the average dail y consumption estimate for that food/food form to produce a residue intake estimate. The resulting residue intake estimate for each food/food form is summed with the residue int ake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure is performed for each population subgroup. For acute exposure assessments, individual one - day food consumption data are used on an individual - by - individual basis. The reported consumption amounts of each food item can be multiplied by

a residue point estimate and summed to obtain a total da ily pesticide exposure for a deterministic exposure assessment, or “matched” in multiple random pairings with residue values and then summed in a probabilistic assessment. The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating relevant commodities/food forms) and a per - capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis. In accordance with HED policy , per capita exposure and risk are reported for all tiers of analy sis. However, for Tiers 1 and 2, any significant differences in user vs. per capita exposure and risk are specificall y identified and noted in the risk assessment. **V. Toxicological Information** The toxicological endpoints as presented in the previous risk assessment are summarized below in Table 2.Fenpyroximate Dietary Exposure and Risk Assessment DP# 405718

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Page 6 of 19 **Table 2. Summary of Toxicological Dose and Endpoints for Fenpyroxim ate for Use in Dietary Risk Assessment**  **1 .**  Exposure Scenario Point of

Departure Uncertainty/FQPA Safety

Factors Study and Toxicological Effects Ac ute Dietary (Females 13 - 49 years old) NOAEL = 5.0

mg/kg bw UF = 100X

(for inter - and intra - species extrapolation) FQPA SF = 1X aRfD = aPAD = 0.05 mg/kg bw Prenatal Developmental Toxicity Study - Rat LOAEL = 25 mg/kg/day based on increase in the fetal incidence of additional thoracic ribs. Ac ute Dietary (General population) NOAEL = 37.5

mg/kg bw UF = 100X

(for inter - and intra - species extrapolation) FQPA SF = 1X aRfD = aPAD = 0.375 mg/kg bw Ac ute Neurotoxicity Study

– Rat LOAEL = 150 mg/kg bw based on decreased mo tor activity (total activity counts and total time spent in movement) in both sexes, and a reduction in auditory startle response in females at 24 hours post dose, and mild dehydration in males. Chronic Dietary (All populations) NOAEL = 5.0

mg/kg/day UF = 100X

(for inter - and intra - species extrapolation) FQPA SF = 1X cRfD = cPAD = 0.05 mg/kg/day Chronic toxicity - Dog LOAEL = 15 mg/kg/day based on an increased incidence of bradycardia, diarrhea, and decrease s in cholesterol, body - weight gain, and food consumption (M); vomiting, diarrhea, excess salivation and decrease cholesterol in females. Cancer (Oral, dermal, inhalation) Classification: “Not likely to be carcinogen,” cancer risk assessment is not required.

1 NOAEL = no - observed adverse - effect level, LOAEL = lowest - observed adverse - effect level, RfD = reference dose, PAD = population - adjusted dose (a = acute, c = chronic), MOE = margin of exposure, UF = uncertainty factor, SF = safety factor. 

### VI. Results/Discussion Acute and chronic anal ys es were performed using DEEM - FCID (ver. 3.16). DEEM - FCID (ver. 3.16) estimates the dietary exposure of the U.S. population and various population subgroups. The results reported are for th e general U.S. population, all infants (<1 ye ar old), children 1 - 2 ye ars old, children 3 - 5 y ears old, children 6 - 12 y ears old, youth 13 - 19 y ears old, females 13 - 49 ye ars old, adults 20 - 49 years old, and adults 50 - 99 y ears old. The resulting acute food p lus drinking water risk estimates are not of concern to HED (<100% aPAD) at the 95 th 

### percentile of the exposure. The resulting acute risk estimate is 13% of the aPAD at the 95 th 

### percentile of the exposure distribution for females 13 to 49 y ears old. The highest acute exposure estimate for the U.S. population or population subgroup is children 1 - 2 ye ars old , which resulted in a risk estimate of 6.2% aPAD. The resulting chronic exposure estimates are not of concern to HED. The most h ighly exposed population was children 1 - 2 y ears old utilizing 15% of the cPAD (s ee Table 3 for a summary of the results). A chronic cancer dietary assessment was not conducted since it was determined that fenp yroximate is not a possible human carcinogen.Fenpyroximate Dietary Exposure and Risk Assessment DP# 405718

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Page 7 of 19 **Table 3. Summary of Dietary (Food + Drinking Water)**  **Exposure and Risk for Fenpyroxim ate.**  Population Subgroup 1 Ac ute Dietary2 (95 Percentile) Chronic Dietary3 Cancer Dietary Exposure (mg/kg/day) % aPAD Dietary Exposure (mg/kg/day) % cPAD Dietary Exposure (mg/kg/day) Risk General U.S. Population 0.008312 2.2 0.002208 4.4

NA NA All Infants (<1 year old) 0.022585 6.0 0.004700 9.4 Children 1 - 2 y ears old **0.023191 6.2**  **0.007336 15**  Children 3 - 5 y ears old 0.016596 4.4 0.005098 10 Children 6 - 12 years old 0.009835 2.6 0.002723 5.4 Youth 13 - 19 y ears old 0.005336 1.4 0.001394 2.8 Adults 20 - 49 y ears old 0.006565 1.8 0.001712 3.4 Adults 50 - 99 y ears old 0.006917 1.8 0.002013 4.0 Females 13 - 49 y ears old **0.006685 13**  0.001693 3.4 1 The values for the highest exposed population for each type of risk assessment is bolded. 2 Separate acute toxicity endpoints were determined for females 13 - 49 years old and the general U.S. population and all population subgroups (see Table 2). 3 Chronic d ietary endpoint of 0.05 mg/kg/day applies to the general U.S. population and all population subgroups. 

### VII. Characterization of Inputs/Outputs The acute and chronic analy ses assumed tolerance - level residues, 100% CT, DEEM (ver. 7.81) default processing factors for all commodities excluding apple, pear, and grape juice (0.11x); grape, raisin (2.7x); orange, grapefruit, tangerine, lemon, and lime juice (0.06x); tomato paste (1.0x) and puree (1.0x); dried plum (1.0x); and peppermint and spearmint oil (0.08x). These anal ys es are considered very conservative and could be refined through the use of anticipated residue estimates (ARs) for all commodities, percent market share data for the proposed commodities, %CT data for registered commodities, and /or additional empirical processing factors. However, at this time refinement is not necessary . **VIII. Conclusions** The acute and chronic dietary exposure and risk assessments were conducted using DEEM FCID , ver. 3.16 . DEEM - FCID incorporates food consumption data from the USDA 's NHANES/WWEIA. Separate acute dietary

risk anal ys es were conducted for females 13 - 49 y ears old and for the general U.S. population , as separate endpoints of concern attributable to a single dose were identified. Both acute analy ses assumed tolerance - level residues, 100% CT, DEEM (ver. 7.81) default processing factors for all commodities excluding apple, pear, and grape juice (0.11x); grape, raisin (2.7x); orange, grapefruit, tangerine, lemon, and lime juice (0.06x); tomato paste (1.0x) and puree (1.0x); dried plum (1.0x); and peppermint and spearmint oil (0.08x). The acute anal ys es also incorporated the drinking water estimates provi ded b y EFED. The EDWCs were unrefined estimates for surface water calculated using the Provisional Cranberry M odel for fenp yroximate and its metabolites (an EDWC of 0.043 ppm was used in the acute anal ys es). The resulting acute food plus drinking water risk estimates are not of concern to HED (<100% aPAD) at the 95 th 

### percentile of the exposure distribution for females 13 to 49 y ears old or the general U.S. population. The resulting acute risk estimate is 13% of the aPAD at the 95 th 

### percentile of the expo sure distribution for females 13 to 49 y ears old. The highest acuteFenpyroximate Dietary Exposure and Risk Assessment DP# 405718

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### exposure estimate for the U.S. population or population subgroup is children 1 - 2 y ears old , which resulted in a risk estimate of 6. 2 % aPAD. The chronic anal ys is assumed tolerance - level r esidues, 100% CT, DEEM (ver. 7.81) default processing factors for most commodities (see above). The chronic anal ys is also incorporated the drinking water estimates provided b y EFED. The EDWCs were unrefined estimates for surface water calculated using th e Provisional Cranberry M odel for fenp yr oximate and its metabolites (an EDWC of 0.0086 ppm was used in the chronic anal ys is). The resulting chronic risk estimates are not of concern to HED. The most highl y exposed population was children 1 - 2 ye ars old ut ilizing 15% of the cPAD. **Attachments** Attachment 1: DEEM - FCID Acute Food + Drinking Water Residue Input File. Attachment 2: DEEM - FCID Acute Exposure Estimates for Females 13 - 49 Years Old. Attachment 3: DEEM - FCID Acute Exposure Estimates for the General U.S. Population Subgroup. Attachment 4: DEEM - FCID Chronic Food + Drinking Water Residue Input File. Attachment 5: DEEM - FCID Chronic Exposure Estimates.

cc: G. Kramer (RAB1) RDI: DE SAC Reviewers (28 - JAN - 2013) G.F. Kram er:S10957:PY - S:(703)305 - 5079:7509P:RAB1Fenpyroximate Dietary Exposure and Risk Assessment DP# 405718

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### Attachment 1: DEEM **- FCID Acute Food + Drinking Water Residue Input File.**  Filename: C: \ Documents and Settings \ gkramer \ My Documents \ Gk \ #$Fenpyroximate \ 129131a.R08 Chemical: Fenpyroximate RfD(Chronic): .05 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day RfD(Acute): .375 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Date created/last modified: 01 - 24 - 2013/14:17:01 Program ver. 3.16, 03 - 08 - d Comment: New uses; added additional acute endpt. for general population

----------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- -- -- ------------------------------- ---------- ------ ------ ------- 0103015000 1CD Arrowroot, flour 0.100000 1.000 1.000 0103015001 1CD Arrowroot, flour - babyfood 0.100000 1.000 1.000 0103017000 1CD Artichoke, Jeru salem 0.100000 1.000 1.000 0103082000 1CD Cassava 0.100000 1.000 1.000 0103082001 1CD Cassava - babyfood 0.100000 1.000 1.000 0103139000 1CD Dasheen, corm 0.100 000 1.000 1.000 0103166000 1CD Ginger 0.100000 1.000 1.000 0103166001 1CD Ginger - babyfood 0.100000 1.000 1.000 0103167000 1CD Ginger, dried 0.100000 1.000 1.000 0103 296000 1C Potato, chips 0.100000 1.000 1.000 0103297000 1C Potato, dry (granules/ flakes) 0.100000 6.500 1.000 0103297001 1C Potato, dry (granules/ flakes) - b 0.100000 6.500 1.000 0103298000 1C Potato, flour 0.100000 6.500 1.000 0103298001 1C Potato, flour - babyfood 0.100000 6.500 1.000 0103299000 1C Potato, tuber, w/peel 0.100000 1.000 1.000 0103299001 1C Potato, tuber, w/peel - babyfood 0.1 00000 1.000 1.000 0103300000 1C Potato, tuber, w/o peel 0.100000 1.000 1.000 0103300001 1C Potato, tuber, w/o peel - babyfood 0.100000 1.000 1.000 0103366000 1CD Sweet potato 0.100000 1.000 1.000 01 03366001 1CD Sweet potato - babyfood 0.100000 1.000 1.000 0103371000 1CD Tanier, corm 0.100000 1.000 1.000 0103387000 1CD Turmeric 0.100000 1.000 1.000 0103406000 1CD Yam, true 0.100000 1.000 1.000 0103407000 1CD Yam bean 0.100000 1.000 1.000 0601043000 6A Bean, snap, succulent 0.400000 1.000 1.000 0601043001 6A Bean, sna p, succulent - babyfood 0.400000 1.000 1.000 0801374000 8A Tomatillo 0.200000 1.000 1.000 0801375000 8A Tomato 0.200000 1.000 1.000 0801375001 8A Tomato - babyfood 0.200000 1.000 1.000 0801376000 8A Tomato, paste 0.200000 1.000 1.000 0801376001 8A Tomato, paste - babyfood 0.200000 1.000 1.000 0801377000 8A Tomato, puree 0.200000 1.000 1.000 0801377001 8A Tomato, puree - babyfood 0.200000 1.000 1.000 0801378000 8A Tomato, dried 0.200000 14.300 1.000 0801378001 8A Tomato, dried - babyfood 0.200000 14.300 1.000 0801379000 8A Tomato, juice 0.200000 1.500 1.000 0801380000 8A Tomato, Tree 0.200000 1.000 1.000 0802148000 8BC Eggplant 0.200000 1.000 1.000 0802234000 8BC Okra 0.200000 1.000 1.000 0802270000 8B Pepper, bell 0.200000 1.000 1.000 0802270001 8B Pepper, bell - babyfood 0.200000 1.000 1.000 0802271000 8B Pepper, bell, dried 0.200000 1.000 1.00 0 0802271001 8B Pepper, bell, dried - babyfood 0.200000 1.000 1.000 0802272000 8BC Pepper, nonbell 0.200000 1.000 1.000 0802272001 8BC Pepper, nonbell - babyfood 0.200000 1.000 1.000 0802273000 8BC Peppe r, nonbell, dried 0.200000 1.000 1.000 0901075000 9A Cantaloupe 0.100000 1.000 1.000 0901187000 9A Honeydew melon 0.100000 1.000 1.000 0901399000 9A Watermelon 0.100000 1.000 1.000 0901400000 9A Watermelon, juice 0.100000 1.000 1.000 0902135000 9B Cucumber 0.400000 1.000 1.000 1001106000 10A Citron 0.500000 1.000 1.000 1001107000 10A Citrus hybrids 0.500000 1.000 1.000 1001108000 10A Citrus, oil 10.000000 1.000 1.000 1001240000 10A Orange 0.500000 1.000 1.000 1001241000 10A Orange, juice 0.500000 0.060 1.000 1001241001 10A Orange, juice - babyfood 0.500000 0.060 1.000 1001242000 10A Orange, peel 0.500000 1.000 1.000Fenpyroximate Dietary Exposure and Risk Assessment DP# 405718

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Page 10 of 19 1001369000 10A Tangerine 0.500000 1.000 1.000 1001370000 10A Tangerine, juice 0.500000 0.060 1.000 1002197000 10B Kumquat 0.500000 1.000 1.000 1002199000 10B Lemon 0.500000 1.000 1.000 1002200000 10B Lemon, juice 0.500000 0.060 1.000 1002200001 10B Lemon, juice - babyfood 0.500000 0.060 1.000 1002201000 10B Lemon, peel 0.500000 1.000 1.000 1002206000 10B Lime 0.500000 1.000 1.000 1002207000 10B Lime, juice 0.500000 0.060 1.000 1002207001 10B Lime, juice - babyfood 0.500000 0.060 1.000 1003180000 10C Grapefruit 0.500000 1.000 1.000 1003181000 10C Grapefruit, juice 0.500000 0.060 1.000 1003307000 10C Pummelo 0.500000 1.000 1.00 0 1100007000 11 Apple, fruit with peel 0.300000 1.000 1.000 1100008000 11 Apple, peeled fruit 0.300000 1.000 1.000 1100008001 11 Apple, peeled fruit - babyfood 0.300000 1.000 1.000 1100009000 11 Apple , dried 0.300000 8.000 1.000 1100009001 11 Apple, dried - babyfood 0.300000 8.000 1.000 1100010000 11 Apple, juice 0.300000 0.110 1.000 1100010001 11 Apple, juice - babyfood 0.300000 0.110 1.000 1100011000 11 Apple, sauce 0.300000 1.000 1.000 1100011001 11 Apple, sauce - babyfood 0.300000 1.000 1.000 1100129000 11 Crabapple 0.300000 1.000 1.000 1100173500 11 Goji berry 0.200000 1.000 1.000 1100210000 11 Loquat 0.300000 1.000 1.000 1100266000 11 Pear 0.300000 1.000 1.000 1100266001 11 Pear - babyfood 0.300000 1.000 1.000 1100267000 11 Pear, dried 0.300000 6.250 1.000 1100268000 11 Pear, juice 0.300000 0.110 1.000 1100268001 11 Pear, juice - babyfood 0.300000 0.110 1.000 1100310000 11 Quince 0.300000 1.000 1.000 1201090000 12A Cherry 2.000000 1.000 1.000 1201090001 12A Cherry - babyfood 2.000000 1.000 1.000 1201091000 12A Cherry, juice 2.000000 1.500 1.000 1201091001 12A Cherry, juice - babyfood 2.000000 1.500 1.000 1202012000 12B Apricot 2.000000 1.000 1.000 1202012001 12B Apricot - babyfood 2.000000 1.000 1.000 1202013000 12B Apricot, dried 2.000000 6.000 1.000 1202014000 12B Apricot, juice 2.000000 1.000 1.000 1202014001 12B Apricot, juice - babyfood 2.000000 1.000 1.000 1202230000 12B Nectarine 2.000000 1.000 1.000 1202260000 12B Peach 2.000000 1.000 1.00 0 1202260001 12B Peach - babyfood 2.000000 1.000 1.000 1202261000 12B Peach, dried 2.000000 7.000 1.000 1202261001 12B Peach, dried - babyfood 2.000000 7.000 1.000 1202262000 12B Peach , juice 2.000000 1.000 1.000 1202262001 12B Peach, juice - babyfood 2.000000 1.000 1.000 1203285000 12C Plum 2.000000 1.000 1.000 1203285001 12C Plum - babyfood 2.000000 1.000 1.000 1203286000 12C Plum, prune, fresh 2.000000 1.000 1.000 1203286001 12C Plum, prune, fresh - babyfood 2.000000 1.000 1.000 1203287000 12C Plum, pru ne, dried 2.000000 1.000 1.000 1203287001 12C Plum, prune, dried - babyfood 2.000000 1.000 1.000 1203288000 12C Plum, prune, juice 2.000000 1.400 1.000 1203288001 12C Plum, prune, juice - babyfood 2.000000 1.400 1.000 1302057000 13B Blueberry 1.000000 1.000 1.000 1302057001 13B Blueberry - babyfood 1.000000 1.000 1.000 1302174000 13B Gooseberry 1.000000 1.000 1.000 1304175000 13D Grape 1.000000 1.000 1.000 1304176000 13D Grape, juice 1.000000 0.110 1.000 1304176001 13D Grape, juice - babyfood 1.000000 0.110 1.000 1304179000 13D Grape, wine and sherry 1.000000 1.000 1.000 1307130000 13G Cranberry 1.000000 1.000 1.000 1307130001 13G Cranberry - babyfood 1.000000 1.000 1.000 1307131000 13G Cranberry, dried 1.000000 1.000 1.000 1307132000 13G Cranberry, juice 1.000000 1.100 1.000 1307132001 13G Cranberry, juice - babyfood 1.000000 1.100 1.000 1307359000 13G Strawberry 1.000000 1.000 1.00 0 1307359001 13G Strawberry - babyfood 1.000000 1.000 1.000 1307360000 13G Strawberry, juice 1.000000 1.000 1.000 1307360001 13G Strawberry, juice - babyfood 1.000000 1.000 1.000Fenpyroximate Dietary Exposure and Risk Assessment DP# 405718

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Page 11 of 19 1400003000 14 Almon d 0.100000 1.000 1.000 1400003001 14 Almond - babyfood 0.100000 1.000 1.000 1400004000 14 Almond, oil 0.100000 1.000 1.000 1400004001 14 Almond, oil - babyfood 0.100000 1.000 1.000 1400059000 14 Brazil nut 0.100000 1.000 1.000 1400068000 14 Butternut 0.100000 1.000 1.000 1400081000 14 Cashew 0.100000 1.000 1.000 1400092000 14 Chestnut 0.100000 1.000 1.000 1400155000 14 Hazelnut 0.100000 1.000 1.000 1400156000 14 Hazelnut, oil 0.100000 1.000 1.000 1400185000 14 Hickory nut 0.100000 1.000 1.000 1400213000 14 Macadamia nut 0.100000 1.000 1.000 1400269000 14 Pecan 0.100000 1.000 1.000 1400282000 14 Pistachio 0.100000 1.000 1.000 1400391000 14 Walnut 0.100000 1.000 1.000 1500120000 15 Corn, field, flour 0.020000 1.000 1.000 1500120001 15 Corn, field, flour - babyfood 0.020000 1.000 1.000 1500121000 15 Corn, field, meal 0.020000 1.000 1.000 1500121001 15 Corn, field, meal - babyfood 0.020000 1.000 1.000 1500122000 15 Corn, f ield, bran 0.020000 1.000 1.000 1500123000 15 Corn, field, starch 0.020000 1.000 1.000 1500123001 15 Corn, field, starch - babyfood 0.020000 1.000 1.000 1500124000 15 Corn, field, syrup 0.020000 1.500 1.000 1500124001 15 Corn, field, syrup - babyfood 0.020000 1.500 1.000 1500125000 15 Corn, field, oil 0.050000 1.000 1.000 1500125001 15 Corn, field, oil - babyfood 0.050000 1.000 1.00 0 1500126000 15 Corn, pop 0.020000 1.000 1.000 2003128000 20C Cottonseed, oil 0.100000 1.000 1.000 2003128001 20C Cottonseed, oil - babyfood 0.100000 1.000 1.000 3100044000 31 Beef, meat 0.030000 1.000 1.000 3100044001 31 Beef, meat - babyfood 0.030000 1.000 1.000 3100045000 31 Beef, meat, dried 0.030000 1.920 1.000 3100046000 31 Beef, meat byproducts 0.030000 1.000 1.000 3100046001 31 Beef, meat byproducts - babyfood 0.030000 1.000 1.000 3100047000 31 Beef, fat 0.030000 1.000 1.000 3100047001 31 Beef, fat - babyfood 0.030000 1.000 1.000 3100048000 31 Beef, kidney 0.250000 1.000 1.000 3100049000 31 Beef, liver 0.250000 1.000 1.000 3100049001 31 Beef, liv er - babyfood 0.250000 1.000 1.000 3200169000 32 Goat, meat 0.030000 1.000 1.000 3200170000 32 Goat, meat byproducts 0.030000 1.000 1.000 3200171000 32 Goat, fat 0.030000 1.000 1.000 3200172000 32 Goat, kidney 0.250000 1.000 1.000 3200173000 32 Goat, liver 0.250000 1.000 1.000 3300189000 33 Horse, meat 0.030000 1.000 1.000 3500339000 35 Sheep, meat 0.030000 1.000 1.000 3500339001 35 Sheep, meat - babyfood 0.030000 1.000 1.000 3500340000 35 Sheep, meat byproducts 0.030000 1.000 1.000 3500341000 35 Sheep, fat 0.030000 1.000 1.000 3500341001 35 Sheep, fat - babyfood 0.030000 1.000 1.000 3500342000 35 Sheep, kidney 0.250000 1.000 1.000 3500343000 35 Sheep, liver 0.250000 1.000 1.000 3600222000 36 Milk, fat 0.015000 1.000 1.000 3600222001 36 Milk, fat - baby food/infant formu 0.015000 1.000 1.000 3600223000 36 Milk, nonfat solids 0.015000 1.000 1.00 0 3600223001 36 Milk, nonfat solids - baby food/in 0.015000 1.000 1.000 3600224000 36 Milk, water 0.015000 1.000 1.000 3600224001 36 Milk, water - babyfood/infant form 0.015000 1.000 1.000 3600225001 36 Milk, sugar (lactose) - baby food/ 0.015000 1.000 1.000 8601000000 86A Water, direct, all sources 110 - Uncooked; Fresh or N/S; Cook Meth N/S 0.043000 1.000 1.000 8602000000 86B Water, indirect, all sources 0.043000 1.000 1.000 9500020000 O Avocado 0.150000 1.000 1.000 9500074000 O Canistel 0.150000 1.000 1.000 9500177000 O Grape, le aves 1.000000 1.000 1.000 9500178000 O Grape, raisin 1.000000 2.700 1.000 9500186000 O Honey 0.100000 1.000 1.000 9500186001 O Honey - babyfood 0.100000 1.000 1.000 9500188000 O Hop 10.000000 1.000 1.000 9500215000 O Mango 0.150000 1.000 1.000Fenpyroximate Dietary Exposure and Risk Assessment DP# 405718

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Page 12 of 19 9500215001 O Mango - babyfood 0.150000 1.000 1.000 9500216000 O Mango, dried 0.150000 1.000 1.000 9500217000 O Mango, juice 0.150000 1.000 1.000 9500217001 O Mango, juice - babyfood 0.150000 1.000 1.000 9500245000 O Papaya 0.150000 1.000 1.000 9500245001 O Papaya - babyfood 0.150000 1.000 1.000 9500246000 O Papaya, dried 0.150000 1.800 1.000 9500247000 O Papaya, juice 0.150000 1.500 1.000 9500275000 O Peppermint 7.000000 1.000 1.000 9500276000 O Peppermint, oil 7.000000 0.080 1.000 9500333000 O Sapote, Mamey 0.150000 1.000 1.00 0 9500352000 O Spearmint 7.000000 1.000 1.000 9500353000 O Spearmint, oil 7.000000 0.080 1.000 9500372000 O Tea, dried 20.000000 1.000 1.000 9500373000 O Tea, instant 20.000000 1.000 1.000Fenpyroximate Dietary Exposure and Risk Assessment DP# 405718

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Page 13 of 19 

### Attachment 2: DEEM **- FCID Acute Exposure Estimates for Females 13 to 49 Years Old.**  EPA Ver. 3.16, 03 - 08 - d DEEM - FCID ACUTE Analysis for FENPYROXIMATE NHANES 2003 - 2008 2 - Day Residue file: 129131a.R08 Adjustment factor #2 used. Analysis Date: 02 - 01 - 2013/11:22:40 Residue file dated: 02 - 01 - 2013/11:17:00 RAC/FF intake summed over 24 hours Run Comment : "New uses; added additional acute endpt. for general population"

=============================================================================== Summary calculations -- per capita: 95th Percentile 99th Percentile 99.9th Percen tile Exposure % aRfD Exposure % aRfD Exposure % aRfD

---------- -------- ---------- -------- ---------- -------- Female 13 - 49: 0.006685 13.37 0.010890 21.78 0.018888 37. 78Fenpyroximate Dietary Exposure and Risk Assessment DP# 405718

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Page 14 of 19 

### Attachment 3: DEEM **- FCID Acute Exposure Estimates for the General U.S. Population**  **Subgroups.** EPA Ver. 3.16, 03 - 08 - d DEEM - FCID ACUTE Analysis for FENPYROXIMATE NHANES 2003 - 2008 2 - Da y Residue file: 129131a.R08 Adjustment factor #2 used. Analysis Date: 02 - 01 - 2013/11:21:36 Residue file dated: 02 - 01 - 2013/11:17:00 RAC/FF intake summed over 24 hours Run Comment: "New uses; added additional acute endpt. for general population"

=============================================================================== Summary calculations -- per capita: 95th Percentile 99th Percentile 99.9th Percentile Exposure % aRfD Ex posure % aRfD Exposure % aRfD

---------- -------- ---------- -------- ---------- -------- Total US Population: 0.008312 2.22 0.015331 4.09 0.031367 8.36 All Infants: 0.0 22585 6.02 0.038089 10.16 0.064723 17.26 Children 1 - 2: 0.023191 6.18 0.035415 9.44 0.059443 15.85 Children 3 - 5: 0.016596 4.43 0.023834 6.36 0.041924 11.18 Children 6 - 12: 0.009835 2.62 0.017059 4.55 0.029926 7.98 Youth 13 - 19: 0.005336 1.42 0.009026 2.41 0.018289 4.88 Adults 20 - 49: 0.006565 1.75 0.010483 2.80 0.018315 4.88 Adults 50 - 99: 0.006917 1.84 0.011416 3.04 0.017527 4.67Fenpyroximate Dietary Exposure and Risk Assessment DP# 405718

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Page 15 of 19 

### Attachment 4: DEEM **- FCID Chronic Food + Drinking Water Residue Input File.**  Filename: C: \ Documents and Settings \ gkramer \ My Documents \ Gk \ #$Fenpyroximate \ 129131C.R08 Chemical: Fenpyroximate RfD(Chronic): .05 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day RfD(Acute): .375 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Date created/last modified: 02 - 01 - 2013/11:15:04 Program ver. 3. 16, 03 - 08 - d Comment: New uses; added additional acute endpt. for general population

----------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment C ode Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ------- 0103015000 1CD Arrowroot, flour 0.100000 1.000 1.000 0103015001 1CD Arrowroo t, flour - babyfood 0.100000 1.000 1.000 0103017000 1CD Artichoke, Jerusalem 0.100000 1.000 1.000 0103082000 1CD Cassava 0.100000 1.000 1.000 0103082001 1CD Cassava - babyfood 0.100000 1.000 1.000 0103139000 1CD Dasheen, corm 0.100000 1.000 1.000 0103166000 1CD Ginger 0.100000 1.000 1.000 0103166001 1CD Ginger - babyfood 0.100000 1.000 1.000 0103167000 1CD Ginger, dried 0.100000 1.000 1.000 0103296000 1C Potato, chips 0.100000 1.000 1.000 0103297000 1C Potato, dry (granules/ flakes) 0.100000 6.500 1.000 0103297001 1C Potato, dry (granules/ flakes) - b 0.100000 6.500 1.000 0103298000 1C Potato, flour 0.100000 6.500 1.000 0103298001 1C Potato, flour - babyfood 0.100000 6.500 1.000 0103299000 1C Potato, t uber, w/peel 0.100000 1.000 1.000 0103299001 1C Potato, tuber, w/peel - babyfood 0.100000 1.000 1.000 0103300000 1C Potato, tuber, w/o peel 0.100000 1.000 1.000 0103300001 1C Potato, tuber, w/o peel - babyfood 0.100000 1.000 1.000 0103366000 1CD Sweet potato 0.100000 1.000 1.000 0103366001 1CD Sweet potato - babyfood 0.100000 1.000 1.000 0103371000 1CD Tanier, corm 0.100000 1.000 1.000 0103387000 1CD Turmeric 0.100000 1.000 1.000 0103406000 1CD Yam, true 0.100000 1.000 1.000 0103407000 1CD Yam bean 0.100000 1.000 1.000 0601043000 6A Bean, s nap, succulent 0.400000 1.000 1.000 0601043001 6A Bean, snap, succulent - babyfood 0.400000 1.000 1.000 0801374000 8A Tomatillo 0.200000 1.000 1.000 0801375000 8A Tomato 0.200000 1.000 1.000 0801375001 8A Tomato - babyfood 0.200000 1.000 1.000 0801376000 8A Tomato, paste 0.200000 1.000 1.000 0801376001 8A Tomato, paste - babyfood 0.200000 1.000 1.00 0 0801377000 8A Tomato, puree 0.200000 1.000 1.000 0801377001 8A Tomato, puree - babyfood 0.200000 1.000 1.000 0801378000 8A Tomato, dried 0.200000 14.300 1.000 0801378001 8A Tomat o, dried - babyfood 0.200000 14.300 1.000 0801379000 8A Tomato, juice 0.200000 1.500 1.000 0801380000 8A Tomato, Tree 0.200000 1.000 1.000 0802148000 8BC Eggplant 0.200000 1.000 1.000 0802234000 8BC Okra 0.200000 1.000 1.000 0802270000 8B Pepper, bell 0.200000 1.000 1.000 0802270001 8B Pepper, b ell - babyfood 0.200000 1.000 1.000 0802271000 8B Pepper, bell, dried 0.200000 1.000 1.000 0802271001 8B Pepper, bell, dried - babyfood 0.200000 1.000 1.000 0802272000 8BC Pepper, nonbell 0.200000 1.000 1.000 0802272001 8BC Pepper, nonbell - babyfood 0.200000 1.000 1.000 0802273000 8BC Pepper, nonbell, dried 0.200000 1.000 1.000 0901075000 9A Cantaloupe 0.100000 1.000 1.000 0901187000 9A Honeydew melon 0.100000 1.000 1.000 0901399000 9A Watermelon 0.100000 1.000 1.000 0901400000 9A Watermelon, juice 0.100000 1.000 1.000 0902135000 9B Cucumbe r 0.400000 1.000 1.000 1001106000 10A Citron 0.500000 1.000 1.000 1001107000 10A Citrus hybrids 0.500000 1.000 1.000 1001108000 10A Citrus, oil 10.000000 1.000 1.000 1001240000 10A Orange 0.500000 1.000 1.000 1001241000 10A Orange, juice 0.500000 0.060 1.000 1001241001 10A Orange, juice - babyfood 0.500000 0.060 1.00 0 1001242000 10A Orange, peel 0.500000 1.000 1.000Fenpyroximate Dietary Exposure and Risk Assessment DP# 405718

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Page 16 of 19 1001369000 10A Tangerine 0.500000 1.000 1.000 1001370000 10A Tangerine, juice 0.500000 0.060 1.000 1002197000 10B Kumqu at 0.500000 1.000 1.000 1002199000 10B Lemon 0.500000 1.000 1.000 1002200000 10B Lemon, juice 0.500000 0.060 1.000 1002200001 10B Lemon, juice - babyfood 0.500000 0.060 1.000 1002201000 10B Lemon, peel 0.500000 1.000 1.000 1002206000 10B Lime 0.500000 1.000 1.000 1002207000 10B Lime, juice 0.500000 0.060 1.000 1002207001 10B Lime, juice - babyfood 0.500000 0.060 1.000 1003180000 10C Grapefruit 0.500000 1.000 1.000 1003181000 10C Grapefrui t, juice 0.500000 0.060 1.000 1003307000 10C Pummelo 0.500000 1.000 1.000 1100007000 11 Apple, fruit with peel 0.300000 1.000 1.000 1100008000 11 Apple, peeled fruit 0.300000 1.000 1.000 1100008001 11 Apple, peeled fruit - babyfood 0.300000 1.000 1.000 1100009000 11 Apple, dried 0.300000 8.000 1.000 1100009001 11 Apple, dried - babyfood 0.300000 8.000 1.000 1100010000 11 Apple, juice 0.300000 0.110 1.000 1100010001 11 Apple, juice - babyfood 0.300000 0.110 1.000 1100011000 11 Apple, sauce 0.300000 1.000 1.000 1100011001 11 Apple, sauce - babyfood 0.300000 1.000 1.000 1100129000 11 Crabapple 0.300000 1.000 1.000 1100173500 11 Goji berry 0.200000 1.000 1.000 1100210000 11 Loquat 0.300000 1.000 1.000 1100266000 11 Pear 0.300000 1.000 1.000 1100266001 11 Pear - babyfood 0.300000 1.000 1.000 1100267000 11 Pear, dried 0.300000 6.250 1.00 0 1100268000 11 Pear, juice 0.300000 0.110 1.000 1100268001 11 Pear, juice - babyfood 0.300000 0.110 1.000 1100310000 11 Quince 0.300000 1.000 1.000 1201090000 12A Cherr y 2.000000 1.000 1.000 1201090001 12A Cherry - babyfood 2.000000 1.000 1.000 1201091000 12A Cherry, juice 2.000000 1.500 1.000 1201091001 12A Cherry, juice - babyfood 2.000000 1.500 1.000 1202012000 12B Apricot 2.000000 1.000 1.000 1202012001 12B Apricot - babyfood 2.000000 1.000 1.000 1202013000 12B Apricot, dried 2.000000 6.000 1.000 1202014000 12B Apricot, juice 2.000000 1.000 1.000 1202014001 12B Apricot, juice - babyfood 2.000000 1.000 1.000 1202230000 12B Nectarine 2.000000 1.000 1.000 1202260000 12B Peach 2.000000 1.000 1.000 1202260001 12B Peach - babyfood 2.000000 1.000 1.000 1202261000 12B Peach, dried 2.000000 7.000 1.000 1202261001 12B Peach, dried - babyfood 2.000000 7.000 1.000 1202262000 12B Peach, juice 2.000000 1.000 1.000 1202262001 12B Peach, juice - babyfood 2.000000 1.000 1.000 1203285000 12C Plum 2.000000 1.000 1.000 1203285001 12C Plum - babyfood 2.000000 1.000 1.000 1203286000 12C Plum, prune, fresh 2.000000 1.000 1.000 1203286001 12C Plum, prune, fresh - babyfood 2.000000 1.000 1.000 1203287000 12C Plum, prune, dried 2.000000 1.000 1.000 1203287001 12C Plum, prune, dried - babyfood 2.000000 1.000 1.000 1203288000 12C Plum, prune, juice 2.000000 1.400 1.00 0 1203288001 12C Plum, prune, juice - babyfood 2.000000 1.400 1.000 1302057000 13B Blueberry 1.000000 1.000 1.000 1302057001 13B Blueberry - babyfood 1.000000 1.000 1.000 1302174000 13B Goose berry 1.000000 1.000 1.000 1304175000 13D Grape 1.000000 1.000 1.000 1304176000 13D Grape, juice 1.000000 0.110 1.000 1304176001 13D Grape, juice - babyfood 1.000000 0.110 1.000 1304179000 13D Grape, wine and sherry 1.000000 1.000 1.000 1307130000 13G Cranberry 1.000000 1.000 1.000 1307130001 13G Cranberry - babyfood 1.000000 1.000 1.000 1307131000 13G Cranberry, dried 1.000000 1.000 1.000 1307132000 13G Cranberry, juice 1.000000 1.100 1.000 1307132001 13G Cranberry , juice - babyfood 1.000000 1.100 1.000 1307359000 13G Strawberry 1.000000 1.000 1.000 1307359001 13G Strawberry - babyfood 1.000000 1.000 1.000 1307360000 13G Strawberry, juice 1.000000 1.000 1.000 1307360001 13G Strawberry, juice - babyfood 1.000000 1.000 1.000Fenpyroximate Dietary Exposure and Risk Assessment DP# 405718

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Page 17 of 19 1400003000 14 Almond 0.100000 1.000 1.000 1400003001 14 Almond - babyfood 0.100000 1.000 1.000 1400004000 14 Almond, oil 0.100000 1.000 1.000 1400004001 14 Almond, oil - babyfood 0.100000 1.000 1.000 1400059000 14 Brazil nut 0.100000 1.000 1.000 1400068000 14 Buttern ut 0.100000 1.000 1.000 1400081000 14 Cashew 0.100000 1.000 1.000 1400092000 14 Chestnut 0.100000 1.000 1.000 1400155000 14 Hazelnut 0.100000 1.000 1.000 1400156000 14 Hazelnut, oil 0.100000 1.000 1.000 1400185000 14 Hickory nut 0.100000 1.000 1.000 1400213000 14 Macadamia nut 0.100000 1.000 1.00 0 1400269000 14 Pecan 0.100000 1.000 1.000 1400282000 14 Pistachio 0.100000 1.000 1.000 1400391000 14 Walnut 0.100000 1.000 1.000 1500120000 15 Corn, field, flour 0.020000 1.000 1.000 1500120001 15 Corn, field, flour - babyfood 0.020000 1.000 1.000 1500121000 15 Corn, field, meal 0.020000 1.000 1.000 1500121001 15 Corn, field, meal - babyfood 0.020000 1.000 1.000 1500122000 15 Corn, field, bran 0.020000 1.000 1.000 1500123000 15 Corn, field, starch 0.020000 1.000 1.000 1500123001 15 Corn, field, starch - babyfood 0.020000 1.000 1.000 1500124000 15 Corn, field, syrup 0.020000 1.500 1.000 1500124001 15 Corn, field, syrup - babyfood 0.020000 1.500 1.000 1500125000 15 Corn, fie ld, oil 0.050000 1.000 1.000 1500125001 15 Corn, field, oil - babyfood 0.050000 1.000 1.000 1500126000 15 Corn, pop 0.020000 1.000 1.000 2003128000 20C Cottonseed, oil 0.100000 1.000 1.000 2003128001 20C Cottonseed, oil - babyfood 0.100000 1.000 1.000 3100044000 31 Beef, meat 0.030000 1.000 1.000 3100044001 31 Beef, meat - babyfood 0.030000 1.000 1.000 3100045000 31 Beef, meat, dried 0.030000 1.920 1.000 3100046000 31 Beef, meat byproducts 0.030000 1.000 1.000 3100046001 31 Beef, meat byproducts - babyfood 0.030000 1.000 1.000 3100047000 31 Beef, f at 0.030000 1.000 1.000 3100047001 31 Beef, fat - babyfood 0.030000 1.000 1.000 3100048000 31 Beef, kidney 0.250000 1.000 1.000 3100049000 31 Beef, liver 0.250000 1.000 1.000 3100049001 31 Beef, liver - babyfood 0.250000 1.000 1.000 3200169000 32 Goat, meat 0.030000 1.000 1.000 3200170000 32 Goat, meat byproducts 0.030000 1.000 1.00 0 3200171000 32 Goat, fat 0.030000 1.000 1.000 3200172000 32 Goat, kidney 0.250000 1.000 1.000 3200173000 32 Goat, liver 0.250000 1.000 1.000 3300189000 33 Horse , meat 0.030000 1.000 1.000 3500339000 35 Sheep, meat 0.030000 1.000 1.000 3500339001 35 Sheep, meat - babyfood 0.030000 1.000 1.000 3500340000 35 Sheep, meat byproducts 0.030000 1.000 1.000 3500341000 35 Sheep, fat 0.030000 1.000 1.000 3500341001 35 Sheep, fat - babyfood 0.030000 1.000 1.000 3500342000 35 Sheep, ki dney 0.250000 1.000 1.000 3500343000 35 Sheep, liver 0.250000 1.000 1.000 3600222000 36 Milk, fat 0.015000 1.000 1.000 3600222001 36 Milk, fat - baby food/infant formu 0.015000 1.000 1.000 3600223000 36 Milk, nonfat solids 0.015000 1.000 1.000 3600223001 36 Milk, nonfat solids - baby food/in 0.015000 1.000 1.000 3600224000 36 Milk, water 0.015000 1.000 1.000 3600224001 36 Milk, water - babyfood/infant form 0.015000 1.000 1.000 3600225001 36 Milk, sugar (lactose) - baby food/ 0.015000 1.000 1.000 8601000000 86A Water, direct, all sources 110 - Uncooked; Fresh or N/S; Cook Meth N/S 0.008600 1.000 1.000 8602000000 86B Water, indirect, all sources 0.008600 1.000 1.000 9500020000 O Avocado 0.150000 1.000 1.000 9500074000 O Canis tel 0.150000 1.000 1.000 9500177000 O Grape, leaves 1.000000 1.000 1.000 9500178000 O Grape, raisin 1.000000 2.700 1.000 9500186000 O Honey 0.100000 1.000 1.000 9500186001 O Honey - babyfood 0.100000 1.000 1.000 9500188000 O Hop 10.000000 1.000 1.000 9500215000 O Mango 0.150000 1.000 1. 000Fenpyroximate Dietary Exposure and Risk Assessment DP# 405718

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Page 18 of 19 9500215001 O Mango - babyfood 0.150000 1.000 1.000 9500216000 O Mango, dried 0.150000 1.000 1.000 9500217000 O Mango, juice 0.150000 1.000 1.000 9500217001 O Man go, juice - babyfood 0.150000 1.000 1.000 9500245000 O Papaya 0.150000 1.000 1.000 9500245001 O Papaya - babyfood 0.150000 1.000 1.000 9500246000 O Papaya, dried 0.150000 1.800 1.000 9500247000 O Papaya, juice 0.150000 1.500 1.000 9500275000 O Peppermint 7.000000 1.000 1.000 9500276000 O Peppermin t, oil 7.000000 0.080 1.000 9500333000 O Sapote, Mamey 0.150000 1.000 1.000 9500352000 O Spearmint 7.000000 1.000 1.000 9500353000 O Spearmint, oil 7.000000 0.080 1.000 9500372000 O Tea, dried 20.000000 1.000 1.000 9500373000 O Tea, instant 20.000000 1.000 1.000Fenpyroximate Dietary Exposure and Risk Assessment DP# 405718

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Page 19 of 19 

### Attachment 5: DEEM **- FCID Chronic Exposure Estimates.**  EPA Ver. 3.16, 03 - 08 - d DEEM - FCID Chronic analysis for FENPYROXIMATE NHANES 2003 - 2008 2 - day Residue file name: C: \ Documents and Settings \ gkramer \ My Documents \ Gk \ #$Fenpyroximate \ 129131C.R08 Adjustment factor #2 used. Analysis Date 02 - 01 - 2013/11:19:11 Residue file dated: 02 - 01 - 2013/11:15:04 Reference dose (RfD, Chronic) = .05 mg/kg bw/day COMMENT 1: New uses; added additional acute endpt. for general population

=============================================================================== Total exposure by population subgroup

------------------------------------------------------------------------------- Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- ---------------- Total US Population 0.002208 4.4% Hispanic 0.002196 4.4% Non - Hisp - White 0.002285 4.6% Non - Hisp - Black 0.001775 3.5% Non - Hisp - Other 0.002235 4.5% Nursing Infants 0.003063 6.1% Non - Nursing Infants 0.005431 10.9% Female 13+ PREG 0.001848 3.7% Children 1 - 6 0.005749 11.5% Children 7 - 12 0.002458 4.9% Male 13 - 19 0.001337 2.7% Female 13 - 19/NP 0.001458 2.9% Male 20+ 0.001755 3.5% Female 20+/NP 0.001911 3.8% Seniors 55+ 0.002081 4.2% All Infants 0.0047 00 9.4% Female 13 - 50 0.001695 3.4% Children 1 - 2 0.007336 14.7% Children 3 - 5 0.005098 10.2% Children 6 - 12 0.002723 5.4% Youth 13 - 19 0.001394 2.8% Adults 20 - 49 0.001712 3.4% Adults 50 - 99 0.002013 4.0% Female 13 - 49 0.001693 3.4%

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