EX-10.43



 Exhibit 10.43 

CONFIDENTIAL TREATMENT REQUESTED 

CONFIDENTIAL PORTIONS OF THIS DOCUMENT HAVE BEEN REDACTED AND HAVE BEEN SEPARATELY FILED WITH THE SECURITIES AND EXCHANGE COMMISSION. INFORMATION THAT WAS
OMITTED IN THE EDGAR VERSION HAS BEEN NOTED IN THIS DOCUMENT WITH A PLACEHOLDER IDENTIFIED BY THE MARK “[***]. 
 OMB Approval 2700-0042

  

					
	 AMENDMENT OF SOLICITATION/MODIFICATION
OF CONTRACT
	  	  
 1. CONTRACT ID CODE
	  	  

PAGE OF PAGES

	  	 N/A
	  	    1    |         2


																			
	  
 2.
AMENDMENT/MODIFICATION NO.
  
 0006
	 	  
 3. EFFECTIVE DATE

 
 [See block 16C, below]
	 	  
 4.
REQUISITION/PURCHASE REQ. NO.
	 	 5 PROJECT NO, (If applicable)

 
 N/A

	 6. ISSUED BY
  
	 	CODE  	 	 	 	 7. ADMINISTERED BY (If other than Item 6)
	 	CODE  	 	N/A
	  
 National Institutes of Health

National Institute of Allergy and Infectious Diseases

DEA, Office of Acquisitions

Room 3214, Msc 7612
 6700-B
Rockledge Drive
 Bethesda, MD 20892-7612
  
	 	  
         MID
RCB-B
	 	
	 8. NAME AND ADDRESS OF CONTRACTOR (No., Street, County, State and ZIP Code)
	 	( ̈) 	 	 9A. AMENDMENT OF SOLICITATION NO.
	 	 	 	 
	  
 Pfenex, Inc

10790 Roselle Street
 San
Diego, Ca 92121
	 		 		 	 	 	 	 	 	 	 
	 		 		 		 	 9B. DATED (SEE ITEM 11)

 

	 		 		 	  

  X  
	 	  
 10A. MODIFICATION OF
CONTRACT/ORDER NO.
  
   HHSN272201200033C

 

	 	 		 		 		 	 	 		 	 10B. DATED (SEE ITEM 13)

 
 09/27/2012

	 CODE
  
	 	 	 	 	 	 FACILITY CODE

 
	 	 	 	 	 	 	 	 	 	 
	 11. THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS



	
	  ̈ The above numbered
solicitation is amended as set forth in Item 14. The hour end date specified for receipt of Offers         ̈ is extended,
             ̈ is not extended Offers must acknowledge receipt of this amendment prior to the hour and date specified in the solicitation or
as amended, by one of the following methods:
 (a) By completing Items 8 and 15, and returning one (1) copy of the amendment; (b) By
acknowledging receipt of this Amendment on each copy of the offer submitted; or (c) By separate letter or telegram which includes a reference to the solicitation and amendment numbers. FAILURE OF YOUR ACKNOWLEDGEMENT TO BE RECEIVED AT THE PLACE
DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATE SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER. If by virtue of this amendment you desire to change an offer already submitted, such change may be made by telegram or letter, provided
each telegram or letter makes reference to the solicitation and this amendment, and is received prior to the opening hour and date specified.



											
	 12. ACCOUNTING AND APPROPRIATION DATA (if required) 

 



					
	 13. THIS ITEM ONLY APPLIES TO MODIFICATION OF
CONTRACTS/ORDERS.
 IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.

	  
   ( ̈)  
	 	A.	 	 THIS CHANGE ORDER IS ISSUED PURSUANT TO: (Specify authority) THE CHANGES SET FORTH IN ITEM 14
ARE MADE IN THE CONTRACT ORDER NO. IN ITEM 10A.
  

	 	 	B.	 	 THE ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such as
changes in paying office, appropriation data, etc.) SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF
  

	   X	 	C.	 	 THIS SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:

 
 Mutual Agreement of the Parties

 

	 	 	 D.
  
	 	OTHER (Specify type of modification and authority)
	  
  

E.  IMPORTANT:    Contractor         ̈ is
not,        x is required to sign this document and return 2 copies to the issuing office.

 



											
	 14. DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract subject
matter where feasible.)
  
 PURPOSE:  The purpose of the modification
is to revise ARTICLE G.2.


  

			
	 TOTAL FUNDS CURRENTLY ALLOTTED : $3,031,414 (Unchanged)

TOTAL ESTIMATED COST: $3,031,414 (Unchanged)
	  	 FUNDED THROUGH DATE: March 31, 2016 (Unchanged)

COMPLETION DATE: March 31, 2016 (Uncharged)



 

											
	Except as provided herein, all terms and conditions of the document referenced in Item 9A or 10A, as heretofore changed, remains unchanged and in full force and
effect.


									
	 15A. NAME AND TITLE OF SIGNER (Type or print)
	 	 16A. NAME AND TITLE OF CONTRACTING OFFICER (Type or print)

 

	  
 HUBERT CHEN - CHIEF MEDICAL
OFFICER
	 	 	 	 Michael P. Welsh

Contracting Officer, MID RCB-B, OA, DEA, NIAID, NIH, DHHS
  

	 15B. CONTRACTOR/OFFEROR
  
	 	 15C. DATE SIGNED  
	 	16B: UNITED STATES OF AMERICA	 		 	 16C. DATE SIGNED

	 /s/ Hubert
Chen                                       

	 	 Oct 30, 2015
	 	 By: /s/ Michael P.
Welsh               
	 	 Nov 2, 2015

	 (Signature of person authorized to sign)
	 	 	 	(Signature of Contracting Officer)	 	 

  

					
	NSN 7540-01-152-8070	 	30-105	 	STANDARD FORM 30 (REV. 10-83)
	PREVIOUS EDITION UNUSABLE	 	Computer Generated	 	  Prescribed by GSA
		 		 	  FAR (48 CFR) 53.243


  
 [***] Certain information in this
document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. 









					
	 Contract No: HHSN272201200033C
	  		  	
		  	Modification No: 06	  	 Page 2 of 2


 ARTICLE G.2. KEY PERSONNEL (HHSAR 352.242-70 (January 2006) is hereby modified to update key
personnel as follows: 
  

			
	Name	  	Title
	 [***]
	  	 Principal Investigator

	 [***]
	  	 Deputy Principle Investigator

	 [***]
	  	 Clinician focused on pre-clinical and clinical studies

	 [***]
	  	 Director Downstream Processing (DSP) and Analytical Biochemistry

	 [***]
	  	 Project Manager

	 [***]
	  	 Project Control Manager


  
  

HHS-556 

  
 [***] Certain information in this
document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.