Federal Register / Vol. 76, No. 47 / Thursday, March 10, 2011 / Notices 13193 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

Government-Owned Inventions; 

Availability for Licensing 

AGENCY: National Institutes of Health, 

Public Health Service, HHS. 

ACTION: Notice. 

SUMMARY: The inventions listed below 

are owned by an agency of the U.S. 

Government and are available for 

licensing in the U.S. in accordance with 

35 U.S.C. 207 to achieve expeditious 

commercialization of results of 

federally-funded research and 

development. Foreign patent 

applications are filed on selected 

inventions to extend market coverage 

for companies and may also be available 

for licensing. 

ADDRESSES: Licensing information and 

copies of the U.S. patent applications 

listed below may be obtained by writing 

to the indicated licensing contact at the 

Office of Technology Transfer, National 

Institutes of Health, 6011 Executive 

Boulevard, Suite 325, Rockville, 

Maryland 20852–3804; telephone: 301/ 

496–7057; fax: 301/402–0220. A signed 

Confidential Disclosure Agreement will 

be required to receive copies of the 

patent applications. 

System and Method for Automatic 

Speed Adaptation Control of a 

Treadmill 

Description of Invention: The 

invention offered for further commercial 

development relates to the coupling of 

virtual reality technology with a 

treadmill to implement goal-oriented 

walking practices effectively and to 

promote improved learning skills during 

gait training. The technology will be 

useful in rehabilitation of individuals 

with gait impairments resulting from 

Parkinson’s disease, Traumatic Brain 

Injury, Stroke, Cerebral Palsy, and 

Spinal Cord Injury. In order to allow 

patients practice (e.g., voluntary change 

of walking speed in a natural way), 

software has been developed that 

automatically updates the velocity of a 

treadmill following the intention of the 

person walking on the treadmill. The 

invention uses a swing foot velocity 

measurement to control the velocity of 

the treadmill which can quickly and 

precisely detect the user’s intention of 

changing walking velocity. Swing foot 

velocity measurement allows users to 

voluntarily change walking velocity 

while they have a realistic feel of 

walking (such as over-ground walking). 

We are seeking a CRADA collaborator to 

expand implementation of the invention 

into a fully integrated system that can 

control treadmill velocity in real time 

and can be reliably adapted to typical 

commercial treadmills. 

Applications: 

• Rehabilitation of individuals with 

gait impairments as a complication of 

Parkinson’s disease, traumatic brain 

injury, stroke, cerebral palsy, or spinal 

cord injury. 

• The technology can also be used for 

walking through architectural models, 

for educational purposes (student walk 

through historical sites or geological 

surfaces), military or law enforcement 

training, gaming, motor and sensory 

rehabilitation, and exercise and 

recreation. 

Development Status: Development 

partner with experience designing 

virtual reality environments is sought 

for a CRADA collaboration. 

Inventors: Hyung S. Park (NIH/CC) 

and Jung Won Yoon. 

Relevant Publications: 

1. Lichtenstein L, Barabas J, Woods RL, Peli 

E. A feedback control interface for 

treadmill locomotion in virtual 

environments. ACM Trans Appl Percept. 

2007 Jan;4(1):Article No. 7; doi 

10.1145//1227134.1227141. 

2. Souman JL, Giordano PR, Frissen I, De 

Luca A, Ernst MO. Making virtual 

walking real: Perceptual evaluation of a 

new treadmill control algorithm. ACM 

Trans Appl Percept. 2010 

Feb;7(2):Article No. 11; doi 10.1145// 

1670671.1670675. 

3. Christensen RR, Hollerbach JM, Xu Y, 

Meek SG. Inertial force feedback for the 

treadport locomotion interface. Presence: 

Teleoperators and Virtual Environments. 

2000 Feb;9(1):1–14; doi:10.1162/ 

105474600566574. 

4. von Zitzewitz J, Bernhardt M, Riener R. A 

novel method for automatic treadmill 

speed adaptation. IEEE Trans Neural 

Syst Rehabil Eng. 2007 Sep;15(3):401– 

409. [PubMed: 17894272] 

5. Farnet MG. Treadmill having an automatic 

speed control system. U.S. Patent 

5,368,532 issued November 29, 1994. 

6. Potash RL, Jentges CJ, Burns SK, Potash RJ. 

Adaptive treadmill. U.S. Patent 

5,314,391 issued May 24, 1994. 

7. Minetti AE, Boldrini L, Brusamolin L, 

Zamparo P, McKee T. A feedbackcontrolled treadmill (treadmill-ondemand) and the spontaneous speed of 

walking and running in humans. J Appl 

Physiol. 2003 Aug;95(2):838–843. 

[PubMed: 12692130] 

Patent Status: HHS Reference No. E– 

046–2011/0—One aspect of the overall 

invention currently exists in software 

form, for which the U.S. Government 

will not be seeking patent protection. 

Licensing Status: Available for 

licensing. 

Licensing Contacts: 

• Uri Reichman, PhD, MBA; 301– 

435–4616; UR7a@nih.gov. 

• Michael Shmilovich, Esq.; 301– 

435–5019; ShmilovichM@mail.nih.gov. 

Collaborative Research Opportunity: 

The National Institutes of Health 

Clinical Center is seeking statements of 

capability or interest from parties 

interested in collaborative research to 

further develop, evaluate, or 

commercialize ‘‘A system and method 

for automatic speed adaptation control 

of a treadmill for patients.’’ Please 

contact Dr. Hyung S. Park at 301–451– 

7533 for more information. 

Method for the Detection of a Subdural 

Hematoma Using a Handheld 

Hematoma Detector and Discriminator 

Description of Invention: The 

invention offered for licensing and 

further development is a device and 

method for detecting hematomas. The 

device is based on near infrared light 

emitted perpendicularly into a tissue 

from a non-stationary emitter and on 

continuous detection of the reflected 

light with a non-stationary probe. The 

device is designed as a handheld 

detector that can be used either in an ER 

or at the scene of an accident, which 

will allow the Doctor or EMT to 

diagnose hematoma for patients with a 

Traumatic Brain Injury at the scene. 

Furthermore, this device can be utilized 

to discriminate between subdural and 

epidural hematoma. The invention also 

discloses a novel method of data 

analysis. The specific combination and 

sequences of data analysis are 

performed to discriminate healthy tissue 

from tissue perfused with blood. In 

addition, an interface to a laptop will be 

provided that creates a 3D surface image 

of the location of the hematoma is 

displayed. This invention will result in 

a better triage and treatment for patients 

with Traumatic Brain Injury (TBI) and 

fills a must filled gap in TBI health care. 

Applications: 

• Diagnosis for hematoma 

• Early screening and triage for 

diagnosis of hemorrhage from head 

trauma 

• At-the-scene diagnostic 

• On-going patient monitoring 

• Neurosurgical procedure 

preparation 

• The device will be useful in combat 

critical care and/or third world care 

where CT may not be readily available 

• Potential use of the device in a field 

deployable sense 

Advantages: 

• Improved capabilities of accurately 

diagnosing hematoma 

• At-the-scene detection capabilities 

• The device is inexpensive, simple 

in its design and easy to operate 


jdjones on DSK8KYBLC1PROD with NOTICES
13194 Federal Register / Vol. 76, No. 47 / Thursday, March 10, 2011 / Notices 

• Potential improvement in medical 

procedures 

Development Status: 

• The invention is fully developed 

• May need to develop a prototype for 

testing on phantoms 

Inventors: Jason D. Riley (NICHD) et 

al. 

Patent Status: 

• U.S. Provisional Application No. 

61/286, 626 filed 15 Dec 2009 (HHS 

Reference No. E–010–2010/0–US–01) 

• PCT Application No. PCT/US2010/ 

060506 filed 15 Dec 2010 (HHS 

Reference No. E–010–2010/0–PCT–02) 

Licensing Status: Available for 

licensing. 

Licensing Contacts: 

• Uri Reichman, PhD, MBA; 301– 

435–4616; UR7a@nih.gov. 

• Michael Shmilovich, Esq.; 301– 

435–5019; ShmilovichM@mail.nih.gov. 

Collaborative Research Opportunity: 

The National Institute of Child Health 

and Human Development, Section on 

Biomedical Stochastic Physics, is 

seeking statements of capability or 

interest from parties interested in 

collaborative research to further 

develop, evaluate, or commercialize the 

topic of this invention or related 

laboratory interests. Please contact Alan 

Hubbs, PhD at 301–594–4263 or 

hubbsa@mail.nih.gov for more 

information. 

System and Method for Monitoring and 

Controlling Radio Frequency Signals in 

Interventional Devices 

Description of Invention: The 

invention offered for licensing and 

commercial development is in the field 

of Interventional Magnetic Resonance 

Imaging (‘‘iMRI’’). More specifically the 

invention discloses interventional 

devices in which the heat generated at 

the device during the imaging process 

can be controlled to not exceed 

acceptable levels. 

Interventional devices may heat up 

significantly during an interventional 

MRI procedure as a result of an RF 

induced current on the device. The RF 

induced current is caused by the 

coupling between the interventional 

device and RF electrical fields generated 

by the MRI. As the magnitude of the 

induced RF signal increases, the amount 

of heat that is generated also increases. 

The system of the present invention 

measures the induced RF signal and 

changes a decoupling capacitor value by 

using a varactor and a control circuit to 

adjust the impedance of the device and 

thus controls the magnitude of the RF 

signal. This unique design renders the 

device and the procedures done with it 

safe. 

Applications: 

• Interventional cardiology 

• MRI guided surgery 

Advantages: The device may 

fundamentally enable any ‘‘active’’ MRI 

catheter device to be safe during realtime MRI guided interventional 

procedures. Automated feedback loops 

between RF power applied by the MRI 

scanner and measured power detected 

inside the MRI catheter coil can be used 

to assure safety of ‘‘active’’ MRI catheter 

devices. 

Development Status: In development. 

Prototype is being built. 

Inventors: Ozgur Kocaturk and 

Merdim Sonmez (NHLBI). 

Relevant Publication: Overall WR, 

Pauly JM, Stang PP, Scott GC. Ensuring 

safety of implanted devices under MRI 

using reversed RF polarization. Magn 

Reson Med. 2010 Sep;64(3):823–833. 

[PubMed: 20593374] 

Patent Status: U.S. Provisional 

Application No. 61/430,311 filed 07 Jan 

2011 (HHS Reference No. E–034–2011/ 

0–US–01) 

Licensing Status: Available for 

licensing. 

Licensing Contact: 

• Uri Reichman, PhD, MBA; 301– 

435–4616; UR7a@nih.gov. 

• Michael Shmilovich, Esq.; 301– 

435–5019; ShmilovichM@mail.nih.gov. 

Collaborative Research Opportunity: 

The National Heart, Lung, and Blood 

Institute is seeking statements of 

capability or interest from parties 

interested in collaborative research to 

further develop, evaluate, or 

commercialize safety interventional 

devices during iMRI procedures. Please 

contact Peg Koelble at 

koelblep@nhlbi.nih.gov for more 

information. 

Single Channel MRI Guidewire 

Description of Invention: The 

invention offered for licensing and 

commercial development is in the field 

of Interventional Magnetic Resonance 

Imaging (‘‘iMRI’’). More specifically the 

invention discloses a guidewire for 

magnetic resonance imaging with a 

single channel design to reduce 

complexity and to provide conspicuous 

tip visibility under MRI. In the design 

of the present device, the guidewire 

body includes an antenna formed from 

a rod and a helical coil coupled 

together. The helical coil can have 

multiple windings without a gap 

between the windings. The rod passes 

through the windings of the helical coil 

and is coupled to the helical coil using 

a conductive joint positioned at an end 

of the rod and at an end of the helical 

coil. Insulation can be positioned 

between the rod and the windings of the 

helical coil. The configuration allows 

visibility of the antenna along the length 

of a rod, except where it enters the 

windings of the coil. Thus, the tip 

visibility is enhanced as being separated 

from the rod. 

Applications: 

• Interventional cardiology 

• MRI guided surgery 

Advantages: 

• The unique design of the device 

and its dipole antenna, provide a lower 

profile guidewire (such as coronary 

0.014: guidewire) and it is therefore 

safer and more convenient to use 

compared with existing guidewires. 

• The modified dipole antenna of the 

device can combine the distinct tip 

signal profile typical of loop antennae 

with the whole-shaft visibility of dipole 

antennae, all operating on a single 

receiver channel. This overcomes 

challenges both of conspicuity and of 

undesirable coupling of comparable 

two-channel devices that causes 

heating. 

Development Status: In development. 

Prototype is being built. 

Inventors: Merdim Sonmez, Ozgur 

Kocaturk, and Christina E. Saikus 

(NHLBI) 

Relevant Publications: 

1. Kocaturk O, Kim AH, Saikus CE, Guttman 

MA, Faranesh AZ, Ozturk C, Lederman 

RJ. Active two-channel 0.035’’ guidewire 

for interventional cardiovascular MRI. J 

Magn Reson Imaging. 2009 

Aug;30(2):461–465. [PubMed: 19629968] 

2. Qian D, El-Sharkawy AM, Atalar E, 

Bottomley PA. Interventional MRI: 

tapering improves the distal sensitivity 

of the loopless antenna. Magn Reson 

Med. 2010 Mar;63(3):797–802. [PubMed: 

20187186] 

Patent Status: U.S. Provisional 

Application No. 61/429,833 filed 05 Jan 

2011 (HHS Reference No. E–274–2010/ 

0–US–01) 

Related Technology: U.S. Patent 

Application No. 12/810,481 filed 24 Jun 

2010 (HHS Reference No. E–209–2007/ 

0–US–03), entitled ‘‘Active 0.035 

Guidewire with Two Separate 

Channels’’ 

Licensing Status: Available for 

licensing. 

Licensing Contact: 

• Uri Reichman, PhD, MBA; 301– 

435–4616; UR7a@nih.gov. 

• Michael Shmilovich, Esq.; 301– 

435–5019; ShmilovichM@mail.nih.gov. 

Collaborative Research Opportunity: 

The National Heart, Lung, and Blood 

Institute is seeking statements of 

capability or interest from parties 

interested in collaborative research to 

further develop, evaluate, or 

commercialize technology involving 

single channel MRI guidewires. Please 

contact Peg Koelble at 


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Federal Register / Vol. 76, No. 47 / Thursday, March 10, 2011 / Notices 13195 

koelblep@nhlbi.nih.gov for more 

information. 

Active Adaptive Detuning Systems To 

Improve Safety of Interventional 

Devices 

Description of Invention: The 

invention offered for licensing and 

commercial development is in the field 

of Interventional Magnetic Resonance 

Imaging (‘‘iMRI’’). More specifically the 

invention discloses interventional 

devices in which the heat generated at 

the device during the imaging process 

can be controlled to not exceed 

acceptable levels. 

Active MRI compatible intravascular 

devices contain RF antenna so that they 

are visible under MRI. However, these 

metallic structures may heat up 

significantly during interventional MRI 

procedures due to eddy current 

formation over the conductive 

transmission lines. The electrical field 

coupling between interventional devices 

and RF transmission coils strongly 

depend on the device position and 

orientation within the bore and 

insertion length of the device. Currently, 

conventional detuning circuit is used to 

decouple the conductive intravascular 

device during RF transmission phase of 

the MRI by activating the circuit with a 

PIN diode. However, conventional 

passive techniques do not adapt for each 

possible orientation or insertion length 

of the device. The current invention 

provides for a new active detuning 

system that adapts its circuit component 

to limit heating for every possible 

orientation and insertion length. The 

system reads out the received current 

signal value during RF transmission 

phase and changes the decoupling 

capacitor value by using varactor and 

integrated circuit components to reach 

new resonant condition (very high 

impedance). 

Applications: 

• Interventional cardiology 

• MRI guided surgery 

Advantages: The device may 

fundamentally enable any ‘‘active’’ MRI 

catheter device (independent of the 

orientation and insertion length of the 

device) to be safe during real-time MRI 

guided interventional procedures. 

Development Status: In development. 

Prototype is being built. 

Inventors: Ozgur Kocaturk (NHLBI). 

Patent Status: U.S. Provisional 

Application No. 61/360,998 filed 07 Jul 

2010 (HHS Reference No. E–114–2010/ 

0–US–01) 

Relevant Publication: Overall WR, 

Pauly JM, Stang PP, Scott GC. Ensuring 

safety of implanted devices under MRI 

using reversed RF polarization. Magn 

Reson Med. 2010 Sep;64(3):823–833. 

[PubMed: 20593374] 

Licensing Status: Available for 

licensing. 

Licensing Contact: 

• Uri Reichman, PhD, MBA; 301– 

435–4616; UR7a@nih.gov. 

• Michael Shmilovich, Esq.; 301– 

435–5019; ShmilovichM@mail.nih.gov. 

Collaborative Research Opportunity: 

The National Heart, Lung, and Blood 

Institute is seeking statements of 

capability or interest from parties 

interested in collaborative research to 

further develop, evaluate, or 

commercialize this technology. Please 

contact Peg Koelble at 

koelblep@nhlbi.nih.gov for more 

information. 

Dated: March 4, 2011. 

Richard U. Rodriguez, 

Director, Division of Technology Development 

and Transfer, Office of Technology Transfer, 

National Institutes of Health. 

[FR Doc. 2011–5511 Filed 3–9–11; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

National Institute of Allergy and 

Infectious Diseases; Notice of Closed 

Meeting 

Pursuant to section 10(d) of the 

Federal Advisory Committee Act, as 

amended (5 U.S.C. App.), notice is 

hereby given of the following meeting. 

The meeting will be closed to the 

public in accordance with the 

provisions set forth in sections 

552b(c)(4) and 552b(c)(6), Title 5 U.S.C., 

as amended. The grant applications and 

the discussions could disclose 

confidential trade secrets or commercial 

property such as patentable material, 

and personal information concerning 

individuals associated with the grant 

applications, the disclosure of which 

would constitute a clearly unwarranted 

invasion of personal privacy. 

Name of Committee: National Institute of 

Allergy and Infectious Diseases Special 

Emphasis Panel; Mouse Models of Host 

Responses. 

Date: April 5, 2011. 

Time: 1 p.m. to 5 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: National Institutes of Health, 6700B 

Rockledge Drive, Bethesda, MD 20817. 

Contact Person: Brandt Randall Burgess, 

PhD, Scientific Review Officer, Scientific 

Review Program, Division of Extramural 

Activities, DHHS/NIH/NIAID, 6700B 

Rockledge Drive, MSC 7616, Bethdesda, MD 

20892, 301–451–2584, 

bburgess@niaid.nih.gov. 

(Catalogue of Federal Domestic Assistance 

Program Nos. 93.855, Allergy, Immunology, 

and Transplantation Research; 93.856, 

Microbiology and Infectious Diseases 

Research, National Institutes of Health, HHS) 

Dated: March 4, 2011. 

Jennifer S. Spaeth, 

Director, Office of Federal Advisory 

Committee Policy. 

[FR Doc. 2011–5505 Filed 3–9–11; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

Center for Scientific Review; Notice of 

Closed Meetings 

Pursuant to section 10(d) of the 

Federal Advisory Committee Act, as 

amended (5 U.S.C. App.), notice is 

hereby given of the following meetings. 

The meetings will be closed to the 

public in accordance with the 

provisions set forth in sections 

552b(c)(4) and 552b(c)(6), Title 5 U.S.C., 

as amended. The grant applications and 

the discussions could disclose 

confidential trade secrets or commercial 

property such as patentable material, 

and personal information concerning 

individuals associated with the grant 

applications, the disclosure of which 

would constitute a clearly unwarranted 

invasion of personal privacy. 

Name of Committee: Center for Scientific 

Review Special Emphasis Panel; 

Fellowships: AIDS Predoctoral and 

Postdoctoral. 

Date: March 29, 2011. 

Time: 11 a.m. to 7 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: New York Marriott East Side, 525 

Lexington Avenue at 49th Street, New York, 

NY 10017. 

Contact Person: Shiv A Prasad, PhD, 

Scientific Review Officer, Center for 

Scientific Review, National Institutes of 

Health, 6701 Rockledge Drive, Room 5220, 

MSC 7852, Bethesda, MD 20892, 301–443– 

5779, prasads@csr.nih.gov. 

Name of Committee: Center for Scientific 

Review Special Emphasis Panel; Member 

Conflict Computational Genetics and 

Genomics. 

Date: March 29, 2011. 

Time: 3 p.m. to 5 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: National Institutes of Health, 6701 

Rockledge Drive, Bethesda, MD 20892 

(Telephone Conference Call). 

Contact Person: Malgorzata Klosek, PhD, 

Scientific Review Officer, Center for 

Scientific Review, National Institutes of 

Health, 6701 Rockledge Drive, Room 4188, 

MSC 7849, Bethesda, MD 20892, (301) 435– 

2211, klosekm@csr.nih.gov. 


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