National Institutes of Health ■ U.S.Department of Health and Human Services

Monograph Series

National Institute on Drug Abuse

Compendium

1975–2006
National Institutes of Health

U.S.Department of Health and Human Services

Office of Science Policy and Communications

6001 Executive Boulevard, Room 5213

Bethesda,MD 20892
T

he National Institute on Drug Abuse

(NIDA) supports most of the worldÕs

research on drug abuse and addiction.

NIDA-funded research enables scientists to

apply the most advanced techniques available

to the study of every aspect of drug abuse,

including:

◆ genetic and social determinants of 

vulnerability to drugs;

◆ short- and long-term effects of drugs on 

the brain, including addiction;

◆ health and social impacts of drug abuse,

including infectious diseases and economic

costs; and

◆ development and testing of medication and

behavioral treatments for drug abuse and

addiction.

NIDA has compiled this compendium of

NIDA Research Monographs published from

1975 to 2006. NIDA Research Monographs

are prepared by NIDAÕs research divisions 

and published by its Office of Science Policy

and Communications. The primary objective

of the series is to provide critical reviews 

of research problem areas and techniques,

content of state-of-the-art conferences, and

integrative research reviews. The purpose of

these publications is to disseminate targeted,

scientific information to the professional 

community.

How To Order Research Monographs 

Ordering publications from this compendium

is as easy as picking up your phone or 

downloading them from the NIDA Web site

(www.drugabuse.gov). Most of the monographs listed in this compendium are also

available from the National Technical Information Service (NTIS). For up-to-date pricing

information or to order a specific publication,

call NTIS toll-free (888Ð584Ð8332) or visit 

the NTIS Web site (www.ntis.gov). Prices 

may vary for photocopies, electronic files

(provided via e-mail in PDF format), or 

CD-ROM. Prices listed in this compendium

from NTIS are archival prices for microfiche

and paper copy reports. Prices are subject 

to change.

Copyright Status 

NIDA has obtained permission from the 

copyright holders to reproduce certain previously published material as noted in the

text. Further reproduction of this copyrighted 

material is permitted only as part of a reprinting of the entire publication or chapter. For

any other use, the copyright holderÕs permission is required. All other material in this

compendium, except quoted passages from

copyrighted sources, is in the public domain

and may be used or reproduced without 

permission from the Institute or the authors.

Citation of the source is appreciated.

Opinions expressed in this compendium are

those of the authors and do not necessarily

reflect the opinions or official policy of NIDA

or any other part of the U.S. Department of

Health and Human Services.

Research Monograph Compendium

1975–2006
4 NATIONAL INSTITUTE ON DRUG ABUSE

The U.S. Government does not endorse 

or favor any specific commercial product or

company. Trade, proprietary, or company

names appearing in this publication are used

only because they are considered essential in

the context of the studies reported herein.

NIDA Research Monographs are indexed 

in the Index Medicus. They are selectively

included in the coverage of American Statistics

Index, BioSciences Information Service, 

Chemical Abstracts, Current Contents, Psychological Abstracts, and Psychopharmacology

Abstracts.

Publisher’s Note

NIDA no longer produces its Research 

Monograph series, except for proceedings

from The Annual Scientific Meeting of the

College on Problems of Drug Dependence,

Inc., which takes place annually in June. The

research monographs developed from this

meeting include comprehensive, up-to-date

reviews of research in progress from many

disciplines in drug abuse and dependence,

and are published in April of the following

year. To order free copies of the proceedings,

call the National Clearinghouse for Alcohol

and Drug Information (NCADI) toll-free 

(800-729-6686) or visit the NCADI Web site

(www.health.org).
Research Monograph 1

Findings of Drug Abuse Research 

1975 • Volume I, NTIS PB 272867 $97.50

Volume II, NTIS PB 272868 $89.50

An annotated bibliography of extramural

grant research supported by the National

Institute of Mental Health and the National

Institute on Drug Abuse, from 1967 to 1974.

Research Monograph 2

Operational Definitions in 

Socio-Behavioral Drug Use 

Research 1975 

1976 • NTIS PB 246338 $52

Task force articles proposing consensual

definitions of concepts and terms used 

in psychosocial research to achieve 

operational comparability. 

Research Monograph 3

Aminergic Hypotheses of Behavior:

Reality or Cliché? 

1975 • NTIS PB 246687 $52

Articles examining relation of the brain

monoamines to a range of animal 

and human behaviors. 

Research Monograph 4

Narcotic Antagonists: The Search for

Long-Acting Preparations 

1975 • NTIS PB 247096 $33.50

Articles concerning research on antagonist

delivery systems, such as sustained-release

and long-acting drug devices.

Research Monograph 5

Young Men and Drugs—

A Nationwide Survey

1976 • NTIS PB 247446 $52

Report of a national survey in 1974 

and 1975 measuring drug use by 

men 20–30 years of age.

Research Monograph 6

Effects of Labeling the “Drug Abuser:”

An Inquiry 

1976 • NTIS PB 249092 $33.50

Analysis and review of literature examining

the effects of drug abuse on adolescent

apprehensions and arrests.

Research Monograph 7

Cannabinoid Assays in Humans 

1976 • NTIS PB 251905 $47.50

Articles describing developments in 

measuring methods of cannabinoid levels 

in the human body—immunoassay, liquid

and dual column chromatography, and 

mass spectroscopy techniques.

Research Monograph 8

Rx: 3x/Week LAAM—

Alternative to Methadone

1976 • NTIS PB 253763 $47.50

Comprehensive summary of the development

of LAAM (levo-alpha-acetyl-methodol), 

a drug used for treatment of narcotic 

addiction. 

Research Monograph 9

Narcotic Antagonists:

Naltrexone Progress Report 

1977 • NTIS PB 255833 $59.50

Progress report on naltrexone, from its

development through preclinical and

clinical studies.

Research Monograph 10

Epidemiology of Drug Abuse:

Current Issues

1977 • NTIS PB 266691 $74

Examines methodological problems of

surveys and data collection. 

Research Monograph 11

Drugs and Driving 

1977 • NTIS PB 269602 $52

Research review on the effects of different

drugs on performance impairment, 

particularly on driving. 

Research Monograph 12

Psychodynamics of Drug Dependence 

1977 • NTIS PB 276084 $59.50

A collection of papers discussing the 

role of individual psychodynamics in drug

dependence. 

Research Monograph 13

Cocaine: 1977 

1979 • NTIS PB 269175 $64

A series of reports that discusses cocaine

use and misuse. 

Research Monograph 14

Marijuana Research Findings: 1976

1977 • NTIS PB 271279 $74

Technical papers that discuss research 

findings on the prevalence, use, and 

consequences of using marijuana. 

Research Monograph 15

Review of Inhalants:

Euphoria to Dysfunction

1977 • NTIS PB 275798 $86.50

Defines the nature of the inhalant 

abuse problem.

Research Monograph 16

Epidemiology of Heroin and

Other Narcotics

1978 • NTIS PB 276357 $68.50

Task force report on research technologies

and implications for studying heroin–

narcotic use. 

NIDA Research Monographs
6 NATIONAL INSTITUTE ON DRUG ABUSE

Research Monograph 17

Research on Smoking Behavior

1979 • NTIS PB 276353 $89.50

Explores the epidemiology, etiology, 

and consequences of smoking, as well as

behavioral change in the prevention and

treatment of smoking.

Research Monograph 18

Behavioral Tolerance:

Research and Treatment Implications

1978 • NTIS PB 276337 $89.50

Presents research findings on behavioral 

tolerance in substance abuse and discusses

new avenues for research. Compares and

contrasts theoretical and experimental

approaches to investigations in the field. 

Research Monograph 19

International Challenge of

Drug Abuse

1978 • NTIS PB 293807 $86.50

Papers presented at the VI World Congress 

of Psychiatry (1977), discussing the 

psychobiology of drug abuse and affective

disorders. 

Research Monograph 20

Self-Administration of Abused 

Substances: Methods for Study

1978 • NTIS PB 288471 $74

Techniques used to study the basic 

processes underlying abuse of drugs,

ethanol, food, and tobacco.

Research Monograph 21

Phencyclidine (PCP) Abuse:

An Appraisal

1978 • NTIS PB 288472 $81

Addresses various factors and research 

on PCP use and abuse. 

Research Monograph 22

QUASAR: Quantitative StructureActivity Relationships of 

Analgesics, Narcotic Antagonists,

and Hallucinogens 

1978 • NTIS PB 292265 $103.50

Reports from an interdisciplinary 

conference on the molecular nature of

drug–receptor interactions. 

Research Monograph 23

Cigarette Smoking as a

Dependence Process

1979 • NTIS PB 297721 $64

Explores reasons why the smoking habit

begins, and how it maintains its hold 

despite smokers’ knowledge of the health

consequences. 

Research Monograph 24

Synthetic Estimates for Small Areas:

Statistical Workshop Papers and 

Discussion 

1979 • NTIS PB 299009 $78.50

Papers from a workshop cosponsored by

the National Institute on Drug Abuse and the

National Center for Health Statistics on a

class of statistical approaches that yield 

estimates of data for States and local areas. 

Research Monograph 25

Behavioral Analysis and Treatment 

of Substance Abuse

1979 • NTIS PB 80112428 $74

Papers that present commonalities and

implications for the treatment of dependency

on drugs, ethanol, food, and tobacco. 

Research Monograph 26

The Behavioral Aspects of Smoking

1979 • NTIS PB 80118755 $59.50

Presents the behavioral section of the 

1979 Report of the Surgeon General on

Smoking and Health.

Research Monograph 27

Problems of Drug Dependence, 1979:

Proceedings of the 41st Annual 

Scientific Meeting, the Committee on

Problems of Drug Dependence, Inc.

1980 • NTIS PB 80175482 $111.50

Discusses a range of issues concerning 

the problems of drug use and abuse. 

Research Monograph 28

Narcotic Antagonists:

Naltrexone Pharmacochemistry and

Sustained-Release Preparations 

1981 • NTIS PB 81238875 $78.50

Papers report research on sustained-release

and long-acting devices for use with the 

narcotic antagonist naltrexone. 

Research Monograph 29

Drug Abuse Deaths in Nine Cities:

A Survey Report 

1980 • NTIS PB 80178882 $59.50

Epidemiologic study providing data on 

drug-involved deaths and procedures for 

the investigations. 

Research Monograph 30

Theories on Drug Abuse:

Selected Contemporary Perspectives

1980 • Available only on the NIDA Web site.

Volume presents summaries of the major

contemporary theories of drug abuse by

each of 43 leading theorists. 

Research Monograph 31

Marijuana Research Findings: 1980 

1980 • NTIS PB 80215171 $68.50

Discusses the use and abuse of marijuana

and research findings.
RESEARCH MONOGRAPH COMPENDIUM 1975–2006 7

Research Monograph 32

GC/MS Assays for Abused Drugs 

in Body Fluids

1980 • NTIS PB 81133746 $64

Presents a collection of methods for the

quantitative analysis of various drugs of

abuse using gas chromatography/mass

spectrometry (GC/MS). 

Research Monograph 33

Benzodiazepines:

A Review of Research Results, 1980 

1981 • NTIS PB 82139106 $42.50

A RAUS Review Report on the abuse 

liability of benzodiazepine tranquilizers. 

Research Monograph 34

Problems of Drug Dependence, 1980:

Proceedings of the 42nd Annual 

Scientific Meeting, the Committee on

Problems of Drug Dependence, Inc.

1981 • NTIS PB 81194847 $100

Comprehensive data of ongoing research 

on drug abuse, addiction, and new 

compounds. 

Research Monograph 35

Demographic Trends and Drug Abuse,

1980–1995 

1981 • NTIS PB 82103417 $42.50

Discusses probable estimates of the 

extent and nature of nonmedical drug use,

1980–1995, based on age structure and

other characteristics of the U.S. population. 

Research Monograph 36

New Approaches to Treatment 

of Chronic Pain: A Review of 

Multidisciplinary Pain Clinics and 

Pain Centers 

1981 • NTIS PB 81240913 $64

Discusses the treatment of pain and the

various approaches undertaken by medical

centers and pain centers. 

Research Monograph 37

Behavioral Pharmacology of

Human Drug Dependence

1981 • NTIS PB 82136961 $81

Body of systematically derived data on 

the behavioral mechanisms of drug use 

and abuse.

Research Monograph 38

Drug Abuse and the American 

Adolescent

1981 • NTIS PB 82148198 $47.50

A RAUS Review Report discussing the use of

marijuana: epidemiology, sociodelinquency,

and biomedical consequences among 

American adolescents. 

Research Monograph 39

Young Men and Drugs in Manhattan:

A Causal Analysis 

1981 • NTIS PB 82147372 $64

Examines the etiology and natural history 

of drug use, with a special focus on heroin.

Includes a Lifetime Drug Use Index. 

Research Monograph 40

Adolescent Marijuana Abusers

and Their Families 

1981 • NTIS PB 82113117 $42.50 

A psychodynamic study of adolescents

involved in heavy marijuana use to 

determine what, if any, interaction 

between family and adolescent gives 

rise to drug abuse. 

Research Monograph 41

Problems of Drug Dependence, 1981:

Proceedings of the 43rd Annual 

Scientific Meeting, the Committee on

Problems of Drug Dependence, Inc.

1982 • NTIS PB 82190760 $119.50

Presents abstracts and reports on a wide

range of issues and research concerning

substance abuse. 

Research Monograph 42

The Analysis of Cannabinoids in 

Biological Fluids 

1982 • NTIS PB 83136044 $52

Describes a variety of methodologies for

detection and analysis of cannabinoids,

to meet requirements of researchers and

others for sensitive, reliable, and workable

assays. 

Research Monograph 43

Problems of Drug Dependence, 1982:

Proceedings of the 44th Annual 

Scientific Meeting, the Committee on

Problems of Drug Dependence, Inc.

1983 • NTIS PB 83252692 $117

Includes abstracts and reports regarding

a wide range of drug abuse issues and

research.

Research Monograph 44

Marijuana Effects on the Endocrine

and Reproductive Systems 

1984 • NTIS PB 85150563 $47.50

An analysis of findings and research needs

concerning effects of marijuana use on

endocrine and reproductive functioning in

animals and humans, with special emphasis

on effects upon human pregnancy and fetal

development. 

Research Monograph 45

Contemporary Research in Pain 

and Analgesia, 1983 

1984 • NTIS PB 84184670 $39.50

A RAUS Review Report on the anatomy, 

physiology, and neurochemistry of pain 

and its management. 

Research Monograph 46

Behavioral Intervention Techniques

in Drug Abuse Treatment

1984 • NTIS PB 84184688 $52

Discusses diverse applications of behavioral

interventions, ranging from pharmacological

through broad rehabilitative efforts involved

in socialization and training, to possible

alternative treatment systems based on 

integration into the community at large.
8 NATIONAL INSTITUTE ON DRUG ABUSE

Research Monograph 47

Preventing Adolescent Drug Abuse:

Intervention Strategies 

1983 • NTIS PB 85159663 $74

A RAUS Review Report on a variety of

approaches to prevent adolescent drug

abuse, how they can be applied, their

chances for success, and the need for

future research. 

Research Monograph 48

Measurement in the Analysis and

Treatment of Smoking Behavior

1983 • NTIS PB 84145184 $47.50 

Examines issues, methodologies, and 

technologies in smoking research design

and measurement. Provides an overview 

of knowledge and suggests guidelines 

to increase validity, compatibility, and 

comparability of data across studies.

Research Monograph 49

Problems of Drug Dependence, 1983:

Proceedings of the 45th Annual 

Scientific Meeting,the Committee on

Problems of Drug Dependence, Inc.

1984 • NTIS PB 85151553 $100

A collection of papers in drug abuse

research; also includes reports on tests 

of drug treatment compounds for efficacy

and dependence liability. 

Research Monograph 50

Cocaine: Pharmacology, Effects, and

Treatment of Abuse

1984 • NTIS PB 85150381 $47.50

Discusses topics ranging from mechanisms

of action and assessment of dependence

potential, through analysis of use patterns

and behavioral effects, to review of treatment

strategies. Provides a central reference in

cocaine treatment research.

Research Monograph 51

Drug Abuse Treatment Evaluation:

Strategies, Progress, and Prospects 

1984 • NTIS PB 85150365 $59.50

A review of drug abuse treatment evaluation

and identification of research needs, 

promising approaches, and emerging issues. 

Research Monograph 52

Testing Drugs for Physical 

Dependence Potential and Abuse 

Liability

1984 • NTIS PB 85150373 $52

Presents a review of procedures used to test

drugs for their liability to be abused. Makes

the important distinction between potential

for physical dependence and the broader

concept of abuse liability.

Research Monograph 53

Pharmacological Adjuncts in

Smoking Cessation

1985 • NTIS PB 89123186 $52 

Reviews literature and scientific work on

nicotine and tobacco dependence. Notes

usefulness of integrating behavioral and

pharmacological treatment strategies in

tobacco dependence.

Research Monograph 54

Mechanisms of Tolerance and 

Dependence

1984 • NTIS PB 89103279 $89.50

Discusses the effects and mechanisms

responsible for drug dependence and drug

tolerance associated with the compulsive

use of drugs.

Research Monograph 55

Problems of Drug Dependence, 1984:

Proceedings of the 46th Annual 

Scientific Meeting, the Committee on

Problems of Drug Dependence, Inc.

1985 • NTIS PB 89123194 $97.50

Details various presentations on the 

problems of drug dependence from the 

46th Annual Scientific Meeting.

Research Monograph 56

Etiology of Drug Abuse:

Implications for Prevention

1985 • NTIS PB 89123160 $78.50

Summarizes research findings on the causes

of adolescent drug use and pre-adolescent

risk factors and predictors of drug use.

Identifies priorities for further research.

Research Monograph 57

Self-Report Methods of Estimating

Drug Use: Meeting Current Challenges

to Validity 

1985 • NTIS PB 88248083 $59.50

Examines issues regarding the validity of

self-reported data—such as under-reporting

in direct questioning; noncoverage of 

population groups at risk for drug use; 

and estimating use of low prevalence. 

Research Monograph 58

Progress in the Development 

of Cost-Effective Treatment of 

Drug Abusers 

1988 • NTIS PB 89125017 $59.50

Looks at short-term treatment approaches

that are potentially more effective and cost

efficient than traditional long-term treatments

for drug abuse.

Research Monograph 59

Current Research on the 

Consequences of Maternal Drug

Abuse 

1985 • NTIS PB 89125025 $42.50

Focuses attention on results of clinical 

studies measuring the behavioral, developmental, and cognitive effects of prenatal

abuse of drugs, including marijuana, opiates, PCP, and other drugs in combination; 

examines strengths and weaknesses in the

methods used for these studies. 
RESEARCH MONOGRAPH COMPENDIUM 1975–2006 9

Research Monograph 60

Prenatal Drug Exposure:

Kinetics and Dynamics

1985 • NTIS PB 89124564 $52

Explores research technologies for studying

drug use by the pregnant mother and the

effects on the fetus and newborn; considers

placental transfer of various drugs, alcohol,

and components of cigarette smoke, and

their biotransformation in the placenta 

and fetus. 

Research Monograph 61

Cocaine Use in America:

Epidemiologic and Clinical 

Perspectives

1985 • NTIS PB 89131866 $68.50 

Aims to increase understanding of the 

epidemiology of cocaine use, reviews 

available information about patterns of 

use in the United States, and recommends

ways to expand scientific knowledge about

cocaine use behaviors.

Research Monograph 62

Neuroscience Methods in

Drug Abuse Research

1985 • NTIS PB 89130660 $52

Presents approaches to understanding 

the neurobiological processes that 

underlie drug abuse behavior from a 

variety of disciplines (neurochemistry, 

neurophysiology, and neuroanatomy). 

Research Monograph 63

Prevention Research:

Deterring Drug Abuse Among

Children and Adolescents

1987 • NTIS PB 89103287 $68.50 

Focuses on school-based social skills

and a contrasting cognitive-developmental

approach to substance abuse prevention.

Research Monograph 64

Phencyclidine: An Update

1986 • NTIS PB 89131858 $78.50 

Offers a scientific report on basic biological

mechanisms underlying phencyclidine’s

effects and presents treatment approaches

useful to healthcare personnel and

researchers. 

Research Monograph 65

Women and Drugs: A New Era

for Research

1986 • NTIS PB 89130637 $42.50

Affirms the need to routinely include the

gender variable in drug abuse research. 

Presents data about women and drugs from

preclinical, clinical, and epidemiologic 

studies, and discusses societal, economic,

and physiological factors that relate to drug

use and abuse in women.

Research Monograph 66

Genetic and Biological Markers

in Drug Abuse and Alcoholism 

1986 • NTIS PB 89134423 $47.50

Discusses genetic and biological markers,

identifies research gaps, and recommends

future directions. 

Research Monograph 67

Problems of Drug Dependence, 1985:

Proceedings of the 47th Annual 

Scientific Meeting, the Committee on

Problems of Drug Dependence, Inc.

1986 • NTIS PB 89122337 $119.50 

This meeting commemorated the 50th

Anniversary of the National Institute on 

Drug Abuse’s Intramural Research Program

and the Addiction Research Center (ARC), 

which sought to study the fundamentals of

drug addiction through multidisciplinary

research. 

Research Monograph 68

Strategies for Research on the 

Interactions of Drugs of Abuse 

1986 • NTIS PB 89134936 $68.50

Discusses the interaction of drugs of 

abuse and therapeutic modalities with 

other compounds used on the street or 

therapeutically. 

Research Monograph 69

Opioid Peptides:

Medicinal Chemistry 

1986 • NTIS PB 89158422 $89.50

A comprehensive review of the 

development of new synthetic peptides 

as analgesics and therapeutic drugs 

without addiction liability.

Research Monograph 70

Opioid Peptides:

Molecular Pharmacology,

Biosynthesis, and Analysis

1987 • NTIS PB 89158430 $94.50

Presents basic research of great potential

usefulness, both in further research and in

treatment applications (companion volume

to RM 69). 

Research Monograph 71

Opiate Receptor Subtypes and

Brain Function

1988 • NTIS PB 89151955 $64

Examines the state of knowledge of 

opiate receptor subtypes and specific 

opioid peptides that act on these receptor

subtypes, and considers how brain function

might be related to the diversity of receptor/

ligand combinations.

Research Monograph 72

Relapse and Recovery in Drug Abuse

1986 • NTIS PB 89151963 $64

Reviews long-term studies to assess patterns

of relapse and recovery to better understand

and help clients in treatment. 
10 NATIONAL INSTITUTE ON DRUG ABUSE

Research Monograph 73

Urine Testing for Drugs of Abuse

1987 • NTIS PB 89151971 $47.50 

Answers questions about what urine 

screening can and cannot do, how it fits 

into an overall drug program, and how it

can be used more reliably. Illustrates typical

screening and confirmation techniques for

various abused drugs. 

Research Monograph 74

Neurobiology of Behavioral Control 

in Drug Abuse

1986 • NTIS PB 89151989 $47.50

Examines the personality characteristics that

may contribute to drug abuse and advanced

technologies such as the PET scan that make

it possible to study brain metabolism and

visualize specific receptors in the living

human brain.

Research Monograph 75

Progress in Opioid Research:

Proceedings of the 1986 International

Narcotics Research Conference

1986 • Available only on the NIDA Web site.

Includes sections on: receptor isolation;

multiple opioid receptors and their ligands;

post-receptor events; PCP and its receptor;

novel opioid ligands; synthesis and 

antinociception/analgesia; behavior; and

addiction, tolerance, and dependence. 

Research Monograph 76

Problems of Drug Dependence, 1986:

Proceedings of the 48th Annual 

Scientific Meeting, the Committee on

Problems of Drug Dependence, Inc.

1987 • NTIS PB 88208111 $114

Summary of research into the biological,

behavioral, and chemical bases of drug

abuse. 

Research Monograph 77

Adolescent Drug Abuse:

Analyses of Treatment Research 

1988 • NTIS PB 89125488 $47.50

Presents an overview of adolescent drug

abuse treatment research and points out the

many difficulties associated with adolescent

clinical studies. Reviews research on various

steps in the treatment process—assessment,

treatment selection, treatment delivery, and

aftercare. 

Research Monograph 78

The Role of Neuroplasticity in the

Response to Drugs

1987 • NTIS PB 88245683 $68.50 

Reviews research on how the nervous 

system can alter its response to drugs. 

Summarizes studies of the nervous system

both during development, when it is most

vulnerable to drug effects, and during 

adulthood, when drugs tend to have more

limited and specific effects.

Research Monograph 79

Structure-Activity Relationships of

the Cannabinoids

1987 • NTIS PB 89109201 $68.50

Presents research on methods in which

changing the molecular structures of natural

cannabinoids and their synthetic analogs

alters their effects.

Research Monograph 80

Needle Sharing Among Intravenous

Drug Abusers: National and 

International Perspectives

1988 • NTIS PB 88236138 $64

Describes a variety of programs and 

policies being used in various U.S. cities 

and in Western Europe to reduce the risk 

of intravenous drug users spreading HIV

through the sharing of needles and other

equipment.

Research Monograph 81

Problems of Drug Dependence, 1987:

Proceedings of the 49th Annual 

Scientific Meeting, the Committee on

Problems of Drug Dependence, Inc.

1988 • NTIS PB 89109227 $141

Presents abstracts and reports on a wide

range of issues from the 1987 CPDD 

Meeting on drug dependence. 

Research Monograph 82

Opioids in the Hippocampus

1988 • NTIS PB 88245691 $52

Reviews research on the location and 

functions of opioid peptides and their 

receptors in the hippocampal area of the

brain. Pinpoints gaps in knowledge, 

controversies, and directions for further

research.

Research Monograph 83

Health Hazards of Nitrite Inhalants

1988 • NTIS PB 89125496 $47.50 

Discusses research on the use and effects

of nitrite inhalants and their effects alone or

in combination with other drugs of abuse.

Describes nitrite inhalants’ association with

Kaposi’s sarcoma in AIDS.

Research Monograph 84

Learning Factors in Substance Abuse

1988 • NTIS PB 89125504 $68.50 

Discusses the role of learning—behavior

changes due to experience—in drug taking,

drug abuse, treatment, relapse, and even the

drug economy. Shows how drugs “teach”

the body and nervous system to react to

certain events in new and sometimes

life-threatening ways.
RESEARCH MONOGRAPH COMPENDIUM 1975–2006 11

Research Monograph 85

Epidemiology of Inhalant Abuse:

An Update

1988 • NTIS PB 89123178 $64

Discusses the abuse of volatile solvents,

aerosols, and anesthetics. Identifies 

populations most at risk, and discusses 

various approaches to control, prevention,

and intervention.

Research Monograph 86

Compulsory Treatment of Drug Abuse:

Research and Clinical Practice 

1988 • NTIS PB 89151997 $74

Explores the efficacy of compulsory treatment for drug abusers. Includes studies on

the influence of coercion on a variety of

treatment outcomes, as well as the costs and

potential benefits of compulsory treatment. 

Research Monograph 87

Opioid Peptides: An Update

1988 • NTIS PB 2004105754 $59

Presents information on design and 

synthesis of analgesic agents, conformation

analysis, and mechanisms of analgesia. 

Research Monograph 88

Mechanisms of Cocaine Abuse 

and Toxicity

1988 • NTIS PB 89125512 $86.50 

Reviews advances in knowledge of 

cocaine’s biological and physiological

actions, identifies brain regions involved 

in cocaine’s effects, discusses acute and

chronic toxicity of cocaine use, and 

identifies directions for future research.

Research Monograph 89

Biological Vulnerability to 

Drug Abuse

1988 • NTIS PB 89125520 $59.50 

Discusses strategies for identifying genetic

factors in drug abuse and implications for

treatment and prevention. Presents findings

based in part on family, twin, and adoption

studies and studies of groups at high risk 

for drug abuse.

Research Monograph 90

Problems of Drug Dependence, 1988:

Proceedings of the 50th Annual 

Scientific Meeting, the Committee

on Problems of Drug Dependence, Inc.

1988 • Available only on the NIDA Web site.

Reports on the 50th annual meeting of 

the Committee on Problems of Drug 

Dependence (CPDD) held in June 1988.

Investigators from many disciplines 

presented their research ranging from the

biochemistry of the neuron to the clinical

treatment of drug-dependent patients. 

Research Monograph 91

Drugs in the Workplace:

Research and Evaluation Data 

1989 • NTIS PB 90147257 $84

Describes drug abuse research and 

evaluation activities in the work environment.

Studies include prevalence of drug use 

by the workforce, drug use and job 

performance, and workplace-based efforts

to prevent drug use and treat drug abusers. 

Research Monograph 92

Testing for Abuse Liability of Drugs

in Humans

1989 • NTIS PB 90148933 $94.50

Contains methodologies available for testing

drugs in humans and conclusions about

abuse liability and dependence potential.

Assesses methods for evaluating drugs in

human subjects and describes advantages

and limitations of each approach.

Research Monograph 93

AIDS and Intravenous Drug Abuse:

Future Directions for CommunityBased Prevention Research 

1990 • NTIS PB 90148941 $81 

Presents successful models in prevention/

outreach for AIDS education for drug

abusers and training for drug treatment

personnel. Describes strengths and 

weaknesses of the programs and the 

salient issues to consider when establishing

such a program. 

Research Monograph 94

Pharmacology and Toxicology 

of Amphetamine and Related 

Designer Drugs 

1989 • NTIS PB 90148958 $89.50

Summarizes research findings on the 

neuronal mechanisms through which 

the amphetamines produce their effects, 

and develops a consensus regarding 

future directions that may lead to better

characterizations of the effects of these

drugs on various physiological parameters. 

Research Monograph 95

Problems of Drug Dependence, 1989:

Proceedings of the 51st Annual 

Scientific Meeting, the Committee on

Problems of Drug Dependence, Inc.

1990•NTIS PB 90237660 $152.50

Discusses research into the biological,

behavioral, and chemical bases of drug

abuse. This report includes symposium

papers on medication development programs, methadone maintenance programs,

opiates and chronic pain, and urine testing. 

Research Monograph 96

Drugs of Abuse: Chemistry,

Pharmacology, Immunology,

and AIDS 

1990 • NTIS PB 90237678 $74 

A technical review of research in the 

fields of pharmacology, medicinal 

chemistry, and immunology, as they 

relate to the effects of drug abuse on 

the immune system.

Research Monograph 97

Neurobiology of Drug Abuse:

Learning and Memory 

1990 • NTIS PB 90237686 $74

Assesses the available model systems and

research on the neurobiology of learning

and memory as it relates to the study of drug

abuse. 
12 NATIONAL INSTITUTE ON DRUG ABUSE

Research Monograph 98

The Collection and Interpretation of

Data From Hidden Populations

1990 • NTIS PB 90237694 $52

Explores qualitative approaches to the study

of drug abuse among “hidden” populations.

Focuses primarily on ethnographic research

designs.

Research Monograph 99

Research Findings on Smoking 

of Abused Substances

1990 • NTIS PB 91141119 $59.50

Examines the pharmacological and toxicological effects and the pharmacokinetic 

and behavioral characteristics of smoking

abused substances.

Research Monograph 100

Drugs in the Workplace: Research

and Evaluation Data, Volume II 

1991 • NTIS PB 92146232 $68.50

Contains a discussion of reports and 

studies presented at the 1989 “Drugs in 

the Workplace Conference.” Papers discuss

the nature and extent of the problems of

drugs in the workplace, drug use and job

performance indicators, and Drug-Free

Workplace Program research. 

Research Monograph 101

Residual Effects of Abused Drugs

on Behavior

1990 • NTIS PB 91172858 $54.50

Evaluates the state of knowledge on the

residual effects of chronic substance abuse

on behavior, and fosters an interdisciplinary

research effort to study and understand

long-term drug effects involving both 

laboratory researchers and clinicians. 

Research Monograph 102

Anabolic Steroid Abuse

1990 • NTIS PB 91172866 $74

Discusses whether anabolic steroids possess

abuse potential and whether they play a role

in the abuse of other substances. Includes 

a historical overview of the discovery and

development of anabolic steroids, a critical

evaluation of their performance-enhancing

effects, and an ethnographic study of 

anabolic steroid abuse in New York City. 

Research Monograph 103

Drugs and Violence: Causes,

Correlates, and Consequences

1990 • NTIS PB 91172841 $78.50 

Reports findings from a variety of studies on

aspects of the drug and violence nexus. 

Research Monograph 104

Psychotherapy and Counseling in

the Treatment of Drug Abuse 

1990 • NTIS PB 91172874 $47.50

Describes the methodological problems in

doing psychotherapy and counseling

research and the strategies researchers can

use in dealing with those methodological

problems. 

Research Monograph 105

Problems of Drug Dependence, 1990:

Proceedings of the 52th Annual 

Scientific Meeting, the Committee on

Problems of Drug Dependence, Inc.

1990 • NTIS PB 91198044 $152.50

A compilation of research findings, opinions,

and experiences told by experts in the fields

of drug abuse prevention, treatment, and

research. This collection of papers, presented

at the 1990 CPDD meeting, discusses a 

variety of topics including the use of animals

in research, opiate research, diagnosis,

symptomology, treatment of drug abuse, 

and HIV infection and AIDS. 

Research Monograph 106

Improving Drug Abuse Treatment 

1991 • NTIS PB 92105873 $94.50 

Discusses the various issues, problems,

and successes of treatment services and

research in the 1990s. 

Research Monograph 107

Drug Abuse Prevention Intervention

Research: Methodological Issues 

1991 • NTIS PB 92160985 $78.50

Examines and suggests various methodological approaches to prevention 

intervention. 

Research Monograph 108

Cardiovascular Toxicity of Cocaine:

Underlying Mechanisms

1991 • NTIS PB 92106608 $68.50 

Discusses the potential sites of cocaine’s 

cardiovascular actions and the possible

mechanisms underlying these cardiac 

events in various animal models and in

human tissues.

Research Monograph 109

Longitudinal Studies of

HIV Infection in Intravenous

Drug Users: Methodological

Issues in Natural History Research 

1991 • NTIS PB 92106616 $52

Reviews the natural history of HIV infection

and AIDS in drug-abusing populations.

Examines the many factors that impact the

disease’s acquisition, progression, and

termination.

Research Monograph 110

Epidemiology of Cocaine Use

and Abuse

1991 • NTIS PB 92146240 $84 

Discusses the trends of cocaine use, health,

and social consequences related to cocaine

use and abuse, natural history of cocaine

abuse, predisposing factors for cocaine

users, and the economics and distribution

of cocaine. 
RESEARCH MONOGRAPH COMPENDIUM 1975–2006 13

Research Monograph 111

Molecular Approaches to Drug Abuse

Research: Volume I, Receptor Cloning,

Neurotransmitter Expression, and

Molecular Genetics

1991 • NTIS PB 92135748 $68.50 

Examines progress made in drug abuse

research through molecular approaches.

Reviews technological advances and 

introduces promising research in the 

fields of molecular biology and molecular

genetics and other relevant research areas.

Research Monograph 112

Emerging Technologies and New

Directions in Drug Abuse Research

1991 • NTIS PB 92155449 $84

Discusses the impact of technological

advances on drug abuse research. Focuses

on innovative methods that could alter

directions and applications of research

on drugs of abuse.

Research Monograph 113

Economic Costs,Cost-Effectiveness,

Financing, and Community-Based

Drug Treatment

1991 • NTIS PB 92155795 $68.50

Discusses the role of health services

research in assisting the Nation to improve

the delivery of basic drug abuse treatment. It

examines the methodology of cost-of-illness

estimates and reviews cost-effectiveness 

and benefit-cost studies as linked to the

development of the research agenda. 

Research Monograph 114

Methodological Issues in Controlled

Studies on Effects of Prenatal 

Exposure to Drugs of Abuse

1991 • NTIS PB 92146216 $89.50

Provides a summary of controlled studies

conducted to identify the prenatal effects 

of drugs on behavioral, intellectual, and

physical development of drug-exposed

infants and the reproductive outcome in 

the addicted mother.

Research Monograph 115

Methamphetamine Abuse:

Epidemiologic Issues and Implications

1991 • NTIS PB 92146224 $47.50

Discusses the resurgence of methamphetamine use and addresses issues including

patterns and trends of use; physical and 

biochemical properties of the drug; 

characteristics of the abusing population;

and the manufacturing, marketing, and 

distribution of the drug throughout the

world. 

Research Monograph 116

Drug Discrimination: Applications

to Drug Abuse Research

1991 • NTIS PB 94169471 $94.50

Addresses the techniques and findings of

experiments that analyze how organisms

discriminate drugs from other substances.

Research Monograph 117

Methodological Issues in 

Epidemiological, Prevention, and

Treatment Research on Drug-Exposed

Women and Their Children

1992 • NTIS PB 93102101 $94.50

Considers the effects of prenatal exposure 

to drugs; physical and behavioral aspects of

the mother, child, and their relation to each

other; intervention issues; and legal issues

relating to substance-abusing women and

their children.

Research Monograph 118

Drug Abuse Treatment in

Prisons and Jails

1992 • NTIS PB 93102143 $81 

Provides an overview of drug abuse treatment programs in prisons and jails and

incorporates HIV information relative to this

population. Special issues such as diagnosis,

assessment, case management, and future

directions, are also discussed. 

Research Monograph 119

Problems of Drug Dependence, 1991:

Proceedings of the 53rd Annual 

Scientific Meeting, the Committee on

Problems of Drug Dependence, Inc.

1992 • NTIS PB 93126670 $152.50 

Comprises a review of research from 

many disciplines in drug abuse and drug

dependence. Discusses a wide range of 

topics, from prenatal exposure and 

AIDS to withdrawal and drug treatment 

medications. 

Research Monograph 120

Bioavailability of Drugs to the 

Brain and Blood-Brain Barrier

1992 • NTIS PB 92214956 $74

Demonstrates the importance of the 

blood-brain barrier in understanding 

drug addiction, and affirms that the various

roles of the blood-brain barrier must be

understood to fully comprehend how drugs

affect the central nervous system and the

treatment of drug abuse.

Research Monograph 121

Buprenorphine: An Alternative 

Treatment for Opioid Dependence 

1992 • NTIS PB 93129781 $52

Addresses aspects of the problems of drug

abuse by focusing on the development and

early research findings of buprenorphine 

for the treatment of opioid dependence and

addiction. 

Research Monograph 122

Currently out of print.

Research Monograph 123

Acute Cocaine Intoxication:

Current Methods of Treatment 

1992 • NTIS PB 94115433 $59.50

Provides an overview of methods used 

to treat acute intoxication from cocaine.

Examines the cardiovascular and 

cerebrovascular effects of cocaine; and 

the adverse effects of using other drugs 

with cocaine. 
14 NATIONAL INSTITUTE ON DRUG ABUSE

Research Monograph 124

Neurobiological Approaches to

Brain-Behavior Interaction 

1992 • NTIS PB 93203834 $74 

Discusses the correlations between 

brain changes due to drug use and 

behavioral events. Reviews techniques 

and methodologies for studying the brain

mechanisms that modify behavior. Also

examines advances in technology and

methodologies. 

Research Monograph 125

Activation of Immediate Early Genes

by Drugs of Abuse 

1993 • NTIS PB 94169489 $64

Discusses the effects of drugs of abuse on

the class of genes known as immediateearly genes and methodologies for studying

this area.

Research Monograph 126

Molecular Approaches to Drug 

Abuse Research: Volume II, Structure,

Function, and Expression

1992 • NTIS PB 94169497 $52

Summarizes progress in drug abuse

research achieved through molecular

approaches; reviews relevant advances in

the field of molecular biology and genetics.

Research Monograph 127

Progress and Issues in Case 

Management

1992 • NTIS PB 94169505 $94.50 

Discusses research studies on case 

management in the areas of street outreach,

treatment, waiting list-reduction, and 

criminal justice. Suggests various models 

of case management and their benefits.

Research Monograph 128

Statistical Issues in Clinical Trials for

Treatment of Opiate Dependence

1992 • NTIS PB 93203826 $59.50 

Discusses methods in design and conduct

of clinical trials for treatment of opiate

dependence. Addresses issues of scientific

analysis of clinical trials.

Research Monograph 129

Inhalant Abuse:

A Volatile Research Agenda

1992 • NTIS PB 93183119 $84 

Reviews all areas related to solvent 

abuse—social and abuse patterns, 

clinical evaluation of psychological and

physiological symptoms and disease 

states, treatment, pharmacology, toxicity,

prevention, legal, and economic issues. 

Research Monograph 130

Drug Abuse Among Minority Youth:

Methodological Issues and Recent

Research Advances 

1993 • NTIS PB 94169513 $86.50 

Provides the latest information on the 

patterns, causes, and consequences among

minority individuals. Discusses how to

improve the collection of data when 

conducting drug abuse research among

minority at-risk populations. 

Research Monograph 131

Impact of Prescription Drug Diversion

Control Systems on Medical Practice

and Patient Care

1993 • NTIS PB 94169521 $84

Discusses the impact of prescription drug

abuse on public health, the systems in place

to minimize abuse, and its impact on patient

care. Focuses on gaps in the ability to 

evaluate diversion control systems.

Research Monograph 132

Problems of Drug Dependence, 1992:

Proceedings of the 54th Annual 

Scientific Meeting, the College on

Problems of Drug Dependence, Inc.

1993 • NTIS PB 94115508 $141 

This issue summarizes a wide range of 

drug abuse research topics—from 

prenatal exposure and AIDS to dependence,

withdrawal, and treatment medications. 

Research Monograph 133

Sigma, PCP, and NMDA Receptors 

1993 • NTIS PB 94169539 $74 

Includes information on the 

pharmacological characteristics of 

sigma, PCP, and NMDA-preferring 

glutamate receptors. The properties 

and the functional role these drugs and 

receptors play on biology and behavior 

are also analyzed in detail. 

Research Monograph 134

Medications Development:

Drug Discovery, Databases, and 

Computer-Aided Drug Design

1993 • NTIS PB 94169547 $81

Discusses the drug discovery process and

techniques and technologies used to develop

medications for drug abuse treatment.

Research Monograph 135

Cocaine Treatment:

Research and Clinical Perspectives 

1993 • NTIS PB 94169554 $78.50 

Explores major issues in the treatment of

cocaine abuse and dependence. Reviews

available findings from studies of treatment,

and sets forth recommendations for

research and practice. 
RESEARCH MONOGRAPH COMPENDIUM 1975–2006 15

Research Monograph 136

Assessing Neurotoxicity of

Drugs of Abuse

1993 • NTIS PB 94169562 $78.50 

Discusses a variety of methodologies that

are used in research on the neurotoxicity

of several abused substances including

amphetamine and its congeners, 

tetrahydrocannabinol, and phencyclidine. 

Research Monograph 137

Behavioral Treatments for

Drug Abuse and Dependence 

1993 • NTIS PB 94169570 $84

Provides both clinicians and researchers in

the field of drug abuse with information,

techniques, and procedures regarding

behavioral treatments for drug dependence. 

Research Monograph 138

Imaging Techniques in Medications

Development: Preclinical and Clinical

Aspects

1994 • NTIS PB 94208030 $59.50

Reviews imaging techniques such as PET,

SPECT, and MRI, with special emphasis on

imaging of neural receptors. 

Research Monograph 139

Scientific Methods for Prevention

Intervention Research

1994 • NTIS PB 94208048 $78.50 

Addresses theoretical, methodological, 

and analytical rigor in the design and 

conduct of prevention intervention research,

particularly with minorities.

Research Monograph 140

Problems of Drug Dependence, 1993:

Volume I, Proceedings of the 55th

Annual Scientific Meeting, the College

on Problems of Drug Dependence,

Inc., Plenary Session Symposia and

Annual Reports 

1994 • NTIS PB 94208014 $81

Contains papers presented at the 55th 

Annual Scientific Meeting. Topics include

opioid and cannabinoid receptors, 

innovative treatment approaches, tolerance

and sensitization to opioids and cocaine, 

and hallucinogens.

Research Monograph 141

Problems of Drug Dependence, 1993:

Volume II, Abstracts 

1994 • NTIS PB 94208022 $117

Comprises a review of research abstracts

from many disciplines in drug abuse and

drug dependence. Topics include smoking,

alcohol, cocaine dependence, and tolerance.

Research Monograph 142

Advances in Data Analysis for 

Prevention Intervention Research

1994 • NTIS PB 97101190 $103.50

Discusses statistical techniques and 

methodological issues relevant to prevention

intervention research. Provides general,

introductory, as well as technically detailed

descriptions for a variety of methodological

procedures.

Research Monograph 143

Context of HIV Risk Among Drug Users

and Their Sexual Partners 

1994 • NTIS PB 97101182 $78.50 

Reviews research examining the effects of

the social and environmental context on risk

behaviors and risk avoidance associated

with HIV transmission. 

Research Monograph 144

Therapeutic Community:

Advances in Research and Application 

1994 • NTIS PB 97101174 $84 

Examines research on the therapeutic 

community (TC) approach to substance

abuse treatment. TC emphasizes a social

treatment perspective that focuses on 

re-socializing the client and the use of 

community as an agent of personal change. 

Research Monograph 145

Neurobiological Models for 

Evaluating Mechanisms Underlying

Cocaine Addiction

1994 • NTIS PB 97109490 $68.50 

Presents models used in animal and human

studies for evaluating the neurobiological

basis of cocaine addiction. Among the 

models discussed are self-administration,

brain–stimulation reward, discriminative

stimulus effects, and conditioned effects.

Evidence for the role of dopamine and 

serotonin in mediating different components

of addiction is also critically evaluated. 

Research Monograph 146

Hallucinogens: An Update 

1994 • NTIS PB 97102537 $84

Presents a complete survey of animal and

human hallucinogen research. Discusses 

the regulatory issues involved in human

investigations. Highlights challenges and

opportunities and identifies future research

needs. 

Research Monograph 147

Discovery of Novel Opioid Medications

1995 • NTIS PB 97102529 $84

Reviews the pharmacology, neuropharmacology, and molecular biology of potential

pharmacotherapies for addiction to opioids,

novel opioids, and nonopioids.
16 NATIONAL INSTITUTE ON DRUG ABUSE

Research Monograph 148

Epidemiology of Inhalant Abuse:

An International Perspective

1995 • NTIS PB 97101208 $84

Describes the epidemiology of inhalant 

use and abuse in the United States and in

selected countries. Also describes unique

problems associated with investigations of

inhalant abuse and suggests methodologies

that might be utilized to investigate the 

high-risk, difficult-to-reach groups who

abuse inhalants.

Research Monograph 149

Medications Development for the

Treatment of Pregnant Addicts and

Their Infants

1995 • Available only on the NIDA Web site.

Contains scientists’ presentations on 

medications development for pregnant

addicts and their infants.

Research Monograph 150

Integrating Behavioral Therapies

With Medications in the Treatment

of Drug Dependence

1994 • NTIS PB 97102552 $64

Presents research findings, techniques, and

procedures for integrating psychosocial and

pharmacological treatments.

Research Monograph 151

Social Networks, Drug Abuse, and

HIV Transmission

1995 • NTIS PB 97102545 $74 

Brings together research in the areas of

drug treatment and prevention. Researchers

offer theoretical and methodological 

alternatives to traditional behavioral 

epidemiology based on individual drug

users, by applying network analysis to the

problems of drug abuse and HIV infection. 

Research Monograph 152

Problems of Drug Dependence, 1994:

Proceedings of the 56th Annual 

Scientific Meeting, The College on

Problems of Drug Dependence, Inc.,

Volume I

1995 • NTIS PB 97101158 $74

Contains the plenary session symposia 

and annual reports as presented at the 

56th annual CPDD meeting. 

Research Monograph 153

Problems of Drug Dependence, 1994:

Proceedings of the 56th Annual 

Scientific Meeting, The College on

Problems of Drug Dependence, Inc.,

Volume II

1995 • NTIS PB 97101166 $141

Volume II contains abstracts from 

presentations at the 56th annual CPDD

meeting, which provide a review of research

in progress on drug abuse.

Research Monograph 154

Membranes and Barriers:

Targeted Drug Delivery

1995 • NTIS PB 96106265 $74

Discusses the ability of drugs to effectively

cross various membrane barriers and reach

the receptors to produce biological effects.

Discusses modern design techniques that

make it possible to selectively deliver drugs

to a specific target. 

Research Monograph 155

Reviewing the Behavioral 

Science Knowledge Base on 

Technology Transfer

1995 • NTIS PB 96113931 $78.50 

Contains the development of technology

transfer strategies, setting them in the 

larger context of partnership efforts with

community constituencies and overall

changes in healthcare and information 

technology.

Research Monograph 156

Adolescent Drug Abuse:

Clinical Assessment and 

Therapeutic Interventions

1995 • NTIS PB 96113949 $89.50 

Presents an overview of clinical assessment

procedures, service delivery strategies, 

and therapeutic interventions designed

specifically for youth. Special attention is

given to drug-related medical problems, 

cultural issues, and family involvement.

Research Monograph 157

Qualitative Methods in 

Drug Abuse and HIV Research

1995 • NTIS PB 96120548 $74

Emphasis is on the use of innovative 

ethnographic methods of accessing hidden

populations, target sampling, identifying

drug use and HIV/AIDS risk behaviors,

developing culturally appropriate risk

reduction messages, implementing 

interventions, and evaluating program

results.

Research Monograph 158

Biological Mechanisms and

Perinatal Exposure to Drugs

1995 • NTIS PB 96117411 $68.50

Reviews research findings in the area 

of perinatal exposure to abused drugs 

and its effect on various biological systems

during development.

Research Monograph 159

Individual Differences in the 

Biobehavioral Etiology of Drug Abuse

1996 • NTIS PB 96178363 $89.50

Explores directions for research development in the biobehavioral etiology of 

substance abuse. Addresses the genetic

bases, neurophysiological correlates, and

neurochemical factors underlying drug

abuse risk and resistance.
RESEARCH MONOGRAPH COMPENDIUM 1975–2006 17

Research Monograph 160

Currently out of print. 

Research Monograph 161

Molecular Approaches to Drug Abuse

Research: Volume III, Recent Advances

and Emerging Strategies

1996 • NTIS PB 96177472 $74

Presents research of NIDA’s Molecular Biology and Genetics program. Presents studies

on transgenic models and other genetic

approaches, opioid receptors, and three

families of transporters. Explores future

directions in understanding the molecular

mechanisms underlying drug addiction.

Research Monograph 162

Problems of Drug Dependence, 1995:

Proceedings of the 57th Annual 

Scientific Meeting, The College on

Problems of Drug Dependence, Inc.

1996 • NTIS PB 97160295 $111.50

Contains papers adapted from the symposium

meetings and plenary sessions held at the

57th Annual Scientific Meeting. 

Research Monograph 163

Neurotoxicity and Neuropathology

Associated with Cocaine Abuse

1996 • NTIS PB 96177936 $86.50 

Describes clinical, biochemical, physiological,

and psychological aspects of neurotoxicity

and neuropathology associated with abuse

of cocaine and other psychostimulants, and

proposes placing stimulant dependence in

the category of neurological disorders, in

addition to the class of psychiatric disorders.

Research Monograph 164

Behavioral Studies of Drug-Exposed

Offspring: Methodological Issues in

Human and Animal Research

1996 • NTIS PB 96177944 $84

Discusses the possible adverse behavioral

effects of prenatal drug exposure on the

neonate and developing child. Addresses

many complex methodological issues that

challenge research in this field.

Research Monograph 165

Beyond the Therapeutic Alliance:

Keeping the Drug-Dependent 

Individual in Treatment

1997 • NTIS PB 97186829 $78.50 •

GPO 017-024-01648-9 $24

Reviews treatment research on the best 

ways to retain patients in drug dependence

treatment and guides clinical researchers 

on how to deal with the issue.

Research Monograph 166

Treatment for Drug-Exposed 

Women and Children: Advances in

Research Methodology

1996 • NTIS PB 96179106 $86.50 

Presents experiences, products, and 

procedures associated with NIDA-supported

Perinatal-20 Treatment Research Demonstration Program projects. Describes 

their efforts to expand clinical sites and

implement services research protocols.

Research Monograph 167

The Validity of Self-Reported Drug

Use: Improving the Accuracy of

Survey Estimates

1997•NTIS PB 97175889 $114•GPO 017-024-

01607-1 $40

Examines research on validity using 

internal or external criteria and examines

methodological advances that can contribute

to improved estimates of drug use in 

surveys.

Research Monograph 168

Rural Substance Abuse: State of

Knowledge and Issues

1997 • NTIS PB 97180814 $117

Provides significant information about the

aspects of rural communities, particularly

relative to urban settings, that might affect

patterns of alcohol and drug consumption

and the delivery of services to prevent and

treat alcohol and drug abuse.

Research Monograph 169

Laboratory Behavioral Studies of 

Vulnerability to Drug Abuse

1998 • NTIS PB 98138936 $78.50 

Reviews comprehensive information on

methodological and paradigmatic issues,

as well as recommendations for future

research directions in the field of behavioral

laboratory research on vulnerability to 

drug abuse.

Research Monograph 170

Meta-Analysis of Drug Abuse 

Prevention Programs

1997 • NTIS PB 97154629 $81

Informs the drug abuse prevention 

community of advances in research 

integration methods and scientific findings

about prevention programs.

Research Monograph 171

Currently out of print.

Research Monograph 172

Treatment of Drug-Dependent 

Individuals With Comorbid

Mental Disorders

1997 •NTIS PB 97186829 $64 

Reports treatment research on individuals

with comorbid mental and addictive 

disorders and research on HIV-related

issues among people with comorbid 

conditions.

Research Monograph 173

Pharmacokinetics, Metabolism, and

Pharmaceutics of Drugs of Abuse

1997 •NTIS PB 97181572 $84

Describes research on metabolism, 

pharmacokinetics, and pharmacodynamics

of drugs of abuse. Addresses the ability of

the drugs to cross membrane barriers and

reach receptors effectively according to the

nature of the drug moiety.
18 NATIONAL INSTITUTE ON DRUG ABUSE

Research Monograph 174

Problems of Drug Dependence, 1996:

Proceedings of the 58th Annual 

Scientific Meeting of the College on

Problems of Drug Dependence, Inc.

1997•NTIS PB 97160295 $111.50 

Contains materials not duplicated in any

other publication. Provides information on

findings of preclinical and clinical research

written by the participants at the 58th Annual

Scientific Meeting.

Research Monograph 175

Medication Development for the

Treatment of Cocaine Dependence:

Issues in Clinical Efficacy Trials

1997 •NTIS PB 98116213 $86.50 

Provides an overview of the rationale for

pharmacotherapeutic approaches as well as

issues critical to the design, implementation,

analysis, and interpretation of clinical 

efficacy trials for cocaine medication. 

Research Monograph 176

Cost-Benefit/Cost-Effectiveness

Research of Drug Abuse Prevention:

Implications for Programming 

and Policy

1998 •NTIS PB 98159890 $74 •

GPO 017-024-01626-8 $13.50

Discusses methodologic and analytic

developments in conducting cost and 

cost-effectiveness studies. Assesses the

implications of these studies for the 

development of evidence-based drug 

abuse prevention in the future.

Research Monograph 177

Drug Abuse Prevention Through 

Family Interventions

1998 •NTIS PB 99124315 $117

Based on papers from the technical review,

“Drug Abuse Prevention Through Family

Interventions” held on January 25–26th,

1996, which recognized the primary role

of the family in preventing drug abuse. 

Research Monograph 178

Problems of Drug Dependence, 1997:

Proceedings of the 59th Annual 

Scientific Meeting of the College on

Problems of Drug Dependence, Inc.

1997 •NTIS PB 98157001 $114

Reviews presentations on the problems 

of drug dependence from the 59th Annual

Scientific Meeting.

Research Monograph 179

Problems of Drug Dependence, 1998:

Proceedings of the 60th Annual 

Scientific Meeting of the College on

Problems of Drug Dependence, Inc.

1999 •NTIS PB 9143109 $100

This document details presentations on the

problems of drug dependence from the 60th

Annual Scientific Meeting held in Scottsdale,

Arizona, June 12–17, 1998. 

Research Monograph 180

Problems of Drug Dependence, 1999:

Proceedings of the 61st Annual 

Scientific Meeting of the College on

Problems of Drug Dependence, Inc.

1999 •NTIS PB 2000106384 $111.50

Presentations on the problems of drug

dependence at the 61st Annual Scientific

Meeting held in Acapulco, Mexico,

June 12–17, 1999.

Research Monograph 181

Problems of Drug Dependence, 2000:

Proceedings of the 62nd Annual 

Scientific Meeting of the College on

Problems of Drug Dependence, Inc.

2001 •NTIS PB 2001104757 $59

Details various presentations on the 

problems of drug dependence at the 62nd

Annual Scientific Meeting held in San Juan,

Puerto Rico, on June 17–22, 2000.

Research Monograph 182

Problems of Drug Dependence, 2001:

Proceedings of the 63rd Annual 

Scientific Meeting of the College on

Problems of Drug Dependence, Inc.

2002 •NTIS PB 2002106779 $59

Contains research materials from the 63rd

Annual Scientific Meeting held in Scottsdale,

Arizona, on June 16–21, 2001.

Research Monograph 183

Problems of Drug Dependence, 2002:

Proceedings of the 64th Annual 

Scientific Meeting of the College on

Problems of Drug Dependence, Inc.

2003 •NTIS PB 2003104549 $64.50

Provides presentations on the problems 

of drug dependence from the 64th Annual

Scientific Meeting held in Quebec City, 

Canada, on June 8–13, 2002.

Research Monograph 184

Problems of Drug Dependence, 2003:

Proceedings of the 65th Annual 

Scientific Meeting of the College on

Problems of Drug Dependence, Inc.

2004 •NTIS PB 2005100305 $62.50

Details the presentations on the problems 

of drug dependence at the 65th Annual 

Scientific Meeting held in Bal Harbour,

Florida, on June 14–19, 2003.

Research Monograph 185

Problems of Drug Dependence, 2004:

Proceedings of the 66th Annual 

Scientific Meeting of the College on

Problems of Drug Dependence, Inc.

2005 •NTIS PB 2005106541 $111.50

Reviews the presentations on the problems

of drug dependence at the 66th Annual 

Scientific Meeting held in San Juan, 

Puerto Rico, on June 12–17, 2004.
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Printed 2006