Exhibit 10.2


 





CONVERTIBLE PROMISSORY NOTE



 





	Effective Date: March 4, 2016	 	 	U.S. $655,000.00




 








FOR
VALUE RECEIVED, Protea Biosciences Group, Inc., a Delaware corporation (“Borrower”),
promises to pay to St. George Investments LLC,
a Utah limited liability company, or its successors or assigns (“Lender”),
$655,000.00 and any interest, fees, charges, and late fees on the date that is six
(6) months after the Purchase Price Date (the “Maturity Date”). This Convertible Promissory Note (this “Note”)
is issued and made effective as of March 4, 2016 (the “Effective Date”). This Note is issued pursuant to that
certain Securities Purchase Agreement dated March 4, 2016, as the same may be amended from time to time, by and between Borrower
and Lender (the “Purchase Agreement”). Certain capitalized terms used herein are defined in Attachment 1
attached hereto and incorporated herein by this reference.


 


This Note carries an
OID of $150,000.00. In addition, Borrower agrees to pay $5,000.00 to Lender to cover
Lender’s legal fees, accounting costs, due diligence, monitoring and other transaction costs incurred in connection with
the purchase and sale of this Note (the “Transaction Expense Amount”), all of which amount is included in the
initial principal balance of this Note. The purchase price for this Note, the Origination Shares (as defined in the Purchase Agreement),
and the Warrant (as defined in the Purchase Agreement) shall be $500,000.00 (the
“Purchase Price”), computed as follows: $655,000.00 original principal
balance, less the OID, less the Transaction Expense Amount. The Purchase Price shall be payable by Lender by wire transfer of immediately
available funds. 


 


1.             Prepayment;
Interest.


 


1.1.           
No interest shall accrue on the Outstanding Balance of this Note unless and until an Event of Default (as defined below) occurs.
Immediately following the occurrence of any Event of Default, interest shall automatically accrue on the Outstanding Balance beginning
on the date the applicable Event of Default occurred at an interest rate equal to the lesser of 22% per annum or the maximum rate
permitted under applicable law. Interest calculated hereunder shall be computed on the basis of a 360-day year comprised of twelve
(12) thirty (30) day months, shall compound daily and shall be payable in accordance with the terms of this Note.


 


1.2.           
Borrower may repay this Note at any time as set forth in this Section 1.2. This Note shall be deemed paid in full if Borrower pays
to Lender $580,000.00 on or before the date that is 90 days from the Purchase Price
Date (meaning Borrower would receive a $75,000 discount) (the “Prepayment
Opportunity Date”). If Borrower does not repay this Note in full on or before the Prepayment Opportunity Date, it shall
receive no prepayment discount and must pay the entire Outstanding Balance of this Note in full on or before the Maturity Date.


 







2.             Security. This Note is unsecured.


 


3.             Conversion.


 


3.1.           
Conversion Price. Subject to the adjustments set forth herein, the conversion price (the “Conversion Price”)
for each Conversion (as defined below) shall be equal to 70% (the “Conversion Factor”) multiplied by the lowest
Closing Bid Price in the twenty (20) Trading Days immediately preceding the applicable Conversion. Additionally, if at any time
after the Effective Date, Borrower is not DWAC Eligible, then the then-current Conversion Factor will automatically be reduced
by 5% for all future Conversions. If at any time after the Effective Date, the Common Stock is not DTC Eligible, then the then-current
Conversion Factor will automatically be reduced by an additional 5% for all future Conversions. Finally, in addition to the Default
Effect, if any Major Default occurs after the Effective Date (other than an Event of Default for failure to pay the Outstanding
Balance on the Maturity Date), the Conversion Factor shall automatically be reduced for all future Conversions by an additional
5% for each of the first three (3) Major Defaults that occur after the Effective Date (for the avoidance of doubt, each occurrence
of any Major Default shall be deemed to be a separate occurrence for purposes of the foregoing reductions in Conversion Factor,
even if the same Major Default occurs three (3) separate times). For example, the first time Borrower is not DWAC Eligible, the
Conversion Factor for future Conversions thereafter will be reduced from 70% to 65% for purposes of this example. Following such
event, the first time the Common Stock is no longer DTC Eligible, the Conversion Factor for future Conversions thereafter will
be reduced from 65% to 60% for purposes of this example. If, thereafter, there are three (3) separate occurrences of a Major Default
pursuant to Section 4.1(a), then for purposes of this example the Conversion Factor would be reduced by 5% for the first such occurrence,
and so on for each of the second and third occurrences of such Major Default.


 



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3.2.           
Conversions. Lender has the right at any time following an Event of Default, at its election, to convert (each instance
of conversion is referred to herein as a “Conversion”) all or any part of the Outstanding Balance into shares
(“Conversion Shares”) of fully paid and non-assessable common stock, $0.0001 par value per share (“Common
Stock”), of Borrower as per the following conversion formula: the number of Conversion Shares equals the amount being
converted (the “Conversion Amount”) divided by the Conversion Price. Conversion notices in the form attached
hereto as Exhibit A (each, a “Conversion Notice”) may be effectively delivered to Borrower by any method
of Lender’s choice (including but not limited to facsimile, email, mail, overnight courier, or personal delivery), and all
Conversions shall be cashless and not require further payment from Lender. Borrower shall deliver the Conversion Shares from any
Conversion to Lender in accordance with Section 8 below.


 


3.3.           
Any Conversion Shares issued pursuant hereto that are not Rule 144 Eligible at the time they are issued shall be “restricted
securities” within the meaning of Rule 144 under the Securities Act of 1933, as amended (“Rule 144”),
and the certificate(s) representing the Conversion Shares shall bear a restrictive legend in substantially the following form (and
a stop-transfer order may be placed against transfer of such certificates or other instruments):


 


THE SECURITIES
REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”),
OR ANY STATE SECURITIES LAWS, AND NEITHER SUCH SECURITIES NOR ANY INTEREST THEREIN MAY BE OFFERED, SOLD, PLEDGED, ASSIGNED OR OTHERWISE
TRANSFERRED UNLESS (1) A REGISTRATION STATEMENT WITH RESPECT THERETO IS EFFECTIVE UNDER THE SECURITIES ACT AND ANY APPLICABLE STATE
SECURITIES LAWS, OR (2) AN EXEMPTION FROM SUCH REGISTRATION EXISTS AND THE COMPANY RECEIVES AN OPINION OF COUNSEL TO THE HOLDER
OF SUCH SECURITIES, WHICH COUNSEL AND OPINION ARE SATISFACTORY TO THE COMPANY, THAT SUCH SECURITIES MAY BE OFFERED, SOLD, PLEDGED,
ASSIGNED OR TRANSFERRED IN THE MANNER CONTEMPLATED WITHOUT AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT OR APPLICABLE
STATE SECURITIES LAWS. HEDGING TRANSACTIONS INVOLVING THESE SECURITIES MAY NOT BE CONDUCTED UNLESS IN COMPLIANCE WITH THE SECURITIES
ACT.


 


4.             Defaults and Remedies.


 


4.1.           
Defaults. The following are events of default under this Note (each, an “Event of Default”): (a)
Borrower shall fail to pay any principal, interest, fees, charges, or any other amount when due and payable hereunder; (b) Borrower
shall fail to deliver any Conversion Shares in accordance with the terms hereof; (c) a receiver, trustee or other similar official
shall be appointed over Borrower or a material part of its assets and such appointment shall remain uncontested for twenty (20)
days or shall not be dismissed or discharged within sixty (60) days; (d) Borrower shall become insolvent or generally fails






    	 	2	 



     


    

 


to
pay, or admits in writing its inability to pay, its debts as they become due, subject to applicable grace periods, if any; (e)
Borrower shall make a general assignment for the benefit of creditors; (f) Borrower shall file a petition for relief under any
bankruptcy, insolvency or similar law (domestic or foreign); (g) an involuntary proceeding shall be commenced or filed against
Borrower; (h) Borrower shall default or otherwise fail to observe or perform any material covenant, obligation, condition or agreement
of Borrower contained herein or in any other Transaction Document (as defined in the Purchase Agreement), other than those specifically
set forth in this Section 4.1 and Section 4 of the Purchase Agreement; (i) any representation, warranty or other statement made
or furnished by or on behalf of Borrower to Lender herein, in any Transaction Document, or otherwise in connection with the issuance
of this Note shall be false, incorrect, incomplete or misleading in any material respect when made or furnished; (j) the occurrence
of a Fundamental Transaction without Lender’s prior written consent; (k) Borrower shall fail to maintain the Share Reserve
as required under the Purchase Agreement; (l) Borrower effectuates a reverse split of its Common Stock without twenty (20) Trading
Days prior written notice to Lender (other than a reverse split as described in the Company’s definitive proxy statement
filed with the SEC on August 14, 2015); (m) any money judgment, writ or similar process shall be entered or filed against Borrower
or any subsidiary of Borrower or any of its property or other assets for more than $100,000.00, and shall remain unvacated, unbonded
or unstayed for a period of twenty (20) calendar days unless otherwise consented to by Lender; (n) Borrower shall fail to be DWAC
Eligible; or (o) Borrower shall fail to observe or perform any covenant set forth in Section 4 of the Purchase Agreement.


 


4.2.           
Remedies. At any time and from time to time after Lender becoming aware of the occurrence of any Event of Default,
Lender may accelerate this Note by written notice to Borrower, with the Outstanding Balance becoming immediately due and payable
in cash at the Mandatory Default Amount. Notwithstanding the foregoing, at any time following the occurrence of any Event of Default,
Lender may, at its option, elect to increase the Outstanding Balance by applying the Default Effect (subject to the limitation
set forth below) via written notice to Borrower without accelerating the Outstanding Balance, in which event the Outstanding Balance
shall be increased as of the date of the occurrence of the applicable Event of Default pursuant to the Default Effect, but the
Outstanding Balance shall not be immediately due and payable unless so declared by Lender (for the avoidance of doubt, if Lender
elects to apply the Default Effect pursuant to this sentence, it shall reserve the right to declare the Outstanding Balance immediately
due and payable at any time and no such election by Lender shall be deemed to be a waiver of its right to declare the Outstanding
Balance immediately due and payable as set forth herein unless otherwise agreed to by Lender in writing). Notwithstanding the foregoing,
upon the occurrence of any Event of Default described in clauses (c), (d), (e), (f) or (g) of Section 4.1, the Outstanding Balance
as of the date of acceleration shall become immediately and automatically due and payable in cash at the Mandatory Default Amount,
without any written notice required by Lender. For the avoidance of doubt, Lender may continue making Lender Conversions at any
time following an Event of Default until such time as the Outstanding Balance is paid in full. Additionally, following the occurrence
of any Event of Default, Borrower may, at its option, pay any Conversion in cash instead of Conversion Shares by paying to Lender
on or before the applicable Delivery Date (as defined below) a cash amount equal to the number of Conversion Shares set forth in
the applicable Conversion Notice multiplied by the highest intra-day trading price of the Common Stock that occurs during the period
beginning on the date the applicable Event of Default occurred and ending on the date of the applicable Conversion Notice. In connection
with acceleration described herein, Lender need not provide, and Borrower hereby waives, any presentment, demand, protest or other
notice of any kind, and Lender may immediately and without expiration of any grace period enforce any and all of its rights and
remedies hereunder and all other remedies available to it under applicable law. Such acceleration may be rescinded and annulled
by Lender at any time prior to payment hereunder and Lender shall have all rights as a holder of the Note until such time, if any,
as Lender receives full payment pursuant to this Section 4.2. No such rescission or annulment shall affect any subsequent Event
of Default or impair any right consequent thereon. Nothing herein shall limit Lender’s right to pursue any other remedies
available to it at law or in equity including, without limitation, a decree of specific performance and/or injunctive relief with
respect to Borrower’s failure to timely deliver Conversion Shares upon Conversion of the Notes as required pursuant to the
terms hereof.


 






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4.3.           
Cross Default. A breach or default by Borrower of any payment obligation exceeding $100,000.00 contained in any Other
Agreements that is not cured within thirty (30) calendar days of such breach or default shall, at the option of Lender, be considered
an Event of Default under this Note, in which event Lender shall be entitled (but in no event required) to apply all rights and
remedies of Lender under the terms of this Note.


 


5.             Unconditional Obligation; No Offset. Borrower acknowledges that this Note is an unconditional, valid, binding and
enforceable obligation of Borrower not subject to offset, deduction or counterclaim of any kind. Borrower hereby waives any rights
of offset it now has or may have hereafter against Lender, its successors and assigns, and agrees to make the payments or Conversions
called for herein in accordance with the terms of this Note.


 


6.             Waiver. No waiver of any provision of this Note shall be effective unless it is in the form of a writing signed by
the party granting the waiver. No waiver of any provision or consent to any prohibited action shall constitute a waiver of any
other provision or consent to any other prohibited action, whether or not similar. No waiver or consent shall constitute a continuing
waiver or consent or commit a party to provide a waiver or consent in the future except to the extent specifically set forth in
writing.


 


7.             Effect of Certain Events.


 


7.1.           
Adjustment Due to Distribution. If Borrower shall declare or make any distribution of its assets (or rights to acquire
its assets) to holders of Common Stock as a dividend, stock repurchase, by way of return of capital or otherwise (including any
dividend or distribution to Borrower’s stockholders in cash or shares (or rights to acquire shares) of capital stock of a
subsidiary (i.e., a spin-off)) (a “Distribution”), then Lender shall be entitled, upon any conversion of this
Note after the date of record for determining stockholders entitled to such Distribution, to receive the amount of such assets
which would have been payable to Lender with respect to the shares of Common Stock issuable upon such conversion had Lender been
the holder of such shares of Common Stock on the record date for the determination of stockholders entitled to such Distribution.


 


7.2.           
Adjustments for Stock Split. Notwithstanding anything herein to the contrary, any references to share numbers or
share prices shall be appropriately adjusted for any stock dividend, stock split, stock combination or other similar transaction.


 


8.             Method of Conversion Share Delivery. On or before the close of business on the third (3rd) Trading Day
following the date of delivery of a Conversion Notice (the “Delivery Date”), Borrower shall, provided it is
DWAC Eligible at such time and the Conversion Shares are Rule 144 Eligible, deliver or cause its transfer agent to deliver the
applicable Conversion Shares electronically via DWAC to the account designated by Lender in the applicable Conversion Notice.
If Borrower is not DWAC Eligible or the Conversion Shares are note Rule 144 eligible, it shall deliver to Lender or its broker
(as designated in the Conversion Notice), via reputable overnight courier, a certificate representing the number of shares of Common
Stock equal to the number of Conversion Shares to which Lender shall be entitled, registered in the name of Lender or its designee.
For the avoidance of doubt, Borrower has not met its obligation to deliver Conversion Shares by the Delivery Date unless Lender
or its broker, as applicable, has actually received the certificate representing the applicable Conversion Shares no later than
the close of business on the relevant Delivery Date pursuant to the terms set forth above. Moreover, and notwithstanding anything
to the contrary herein or in any other Transaction Document, in the event Borrower or its transfer agent refuses to deliver any
Conversion Shares to Lender on grounds that the Conversion Shares are not Rule 144 Eligible, Borrower shall deliver or cause its
transfer agent to deliver the applicable Conversion Shares to Lender with a restricted securities legend, but otherwise in accordance
with the provisions of this Section 8. In conjunction therewith, Borrower will also deliver to Lender a written opinion from its
counsel or its transfer agent’s counsel opining as to why the applicable Conversion Shares are not Rule 144 Eligible.


 



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9.             Conversion Delays. If Borrower fails to deliver Conversion Shares in accordance with the timeframe stated in Section
8, Lender, at any time prior to selling all of those Conversion Shares, may rescind in whole or in part, by notice to the Company
in writing, that particular Conversion attributable to the unsold Conversion Shares, and the Outstanding Balance relating to the
unsold Conversion Shares the Conversion of which has been so rescinded will remain part of the Outstanding Balance hereunder (any
returned amount will tack back to the Purchase Price Date for purposes of determining the holding period under Rule 144). In addition,
for each Conversion, in the event that Conversion Shares are not delivered by the fourth Trading Day (inclusive of the day of the
Conversion), a late fee equal to the greater of (a) $500.00 and (b) 2% of the applicable Conversion Share Value rounded to the
nearest multiple of $100.00 (but in any event the cumulative amount of such late fees for each Conversion shall not exceed 200%
of the applicable Conversion Share Value) will be assessed for each day after the third Trading Day (inclusive of the day of the
Conversion) until Conversion Share delivery is made; and such late fee will be added to the Outstanding Balance (such fees, the
“Conversion Delay Late Fees”). For illustration purposes only, if Lender delivers a Conversion Notice to Borrower
pursuant to which Borrower is required to deliver 100,000 Conversion Shares to Lender and on the Delivery Date such Conversion
Shares have a Conversion Share Value of $20,000.00 (assuming a Closing Trade Price on the Delivery Date of $0.20 per share of Common
Stock), then in such event a Conversion Delay Late Fee in the amount of $500.00 per day (the greater of $500.00 per day and $20,000.00
multiplied by 2%, which is $400.00) would be added to the Outstanding Balance of the Note until such Conversion Shares are delivered
to Lender. For purposes of this example, if the Conversion Shares are delivered to Lender twenty (20) days after the applicable
Delivery Date, the total Conversion Delay Late Fees that would be added to the Outstanding Balance would be $10,000.00 (20 days
multiplied by $500.00 per day). If the Conversion Shares are delivered to Lender one hundred (100) days after the applicable Delivery
Date, the total Conversion Delay Late Fees that would be added to the Outstanding Balance would be $40,000.00 (100 days multiplied
by $500.00 per day, but capped at 200% of the Conversion Share Value).


 


10.           Ownership Limitation. Notwithstanding anything to the contrary contained in this Note or the other Transaction Documents,
if at any time Lender shall or would be issued shares of Common Stock under any of the Transaction Documents, but such issuance
would cause Lender (together with its affiliates) to beneficially own a number of shares exceeding 4.99% of the number of shares
of Common Stock outstanding on such date (including for such purpose the shares of Common Stock issuable upon such issuance) (the
“Maximum Percentage”), then Borrower must not issue to Lender shares of Common Stock which would exceed the
Maximum Percentage. For purposes of this section, beneficial ownership of Common Stock will be determined pursuant to Section 13(d)
of the 1934 Act. The shares of Common Stock issuable to Lender that would cause the Maximum Percentage to be exceeded are referred
to herein as the “Ownership Limitation Shares”. Borrower will reserve the Ownership Limitation
Shares for the exclusive benefit of Lender. From time to time, Lender may notify Borrower in writing of the number of the Ownership
Limitation Shares that may be issued to Lender without causing Lender to exceed the Maximum Percentage. Upon receipt of such notice,
Borrower shall be unconditionally obligated to immediately issue such designated shares to Lender, with a corresponding reduction
in the number of the Ownership Limitation Shares. Notwithstanding the forgoing, the term “4.99%” above shall be replaced
with “9.99%” at such time as the Market Capitalization is less than $10,000,000.00. Notwithstanding any other provision
contained herein, if the term “4.99%” is replaced with “9.99%” pursuant to the preceding sentence, such
increase to “9.99%” shall remain at 9.99% until increased, decreased or waived by Lender as set forth below. By written
notice to Borrower, Lender may increase, decrease or waive the Maximum Percentage as to itself but any such waiver will not be
effective until the 61st day after delivery thereof. The foregoing 61-day notice requirement is enforceable, unconditional and
non-waivable and shall apply to all affiliates and assigns of Lender.


 



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11.           Payment of Collection Costs. If this Note is placed in the hands of an attorney for collection or enforcement prior
to commencing arbitration or legal proceedings, or is collected or enforced through any arbitration or legal proceeding, or Lender
otherwise takes action to collect amounts due under this Note or to enforce the provisions of this Note, then Borrower shall pay
the costs incurred by Lender for such collection, enforcement or action including, without limitation, attorneys’ fees and
disbursements. Borrower also agrees to pay for any costs, fees or charges of its transfer agent that are charged to Lender pursuant
to any Conversion or issuance of shares pursuant to this Note.


 


12.           Opinion of Counsel. In the event that an opinion of counsel is needed for any matter related to this Note, Lender
has the right to have any such opinion provided by its counsel. Lender also has the right to have any such opinion provided by
Borrower’s counsel.


 





13.           Governing
Law; Venue. This Note shall be construed and enforced in accordance with, and all questions concerning the construction, validity,
interpretation and performance of this Note shall be governed by, the internal laws of the State of Utah, without giving effect
to any choice of law or conflict of law provision or rule (whether of the State of Utah or any other jurisdiction) that would cause
the application of the laws of any jurisdiction other than the State of Utah. The provisions set forth in the Purchase Agreement
to determine the proper venue for any disputes are incorporated herein by this reference.




 





14.           Resolution of Disputes.


 


14.1.      Arbitration of Disputes. By its acceptance of this Note, each party agrees to be bound by the Arbitration Provisions
(as defined in the Purchase Agreement) set forth as an exhibit to the Purchase Agreement.


 


14.2.      Calculation Disputes. Notwithstanding the Arbitration Provisions, in the case of a dispute as to any Calculation
(as defined in the Purchase Agreement), such dispute will be resolved in the manner set forth in the Purchase Agreement.


 


15.           Cancellation. After repayment or conversion of the entire Outstanding Balance, this Note shall be deemed paid in
full, shall automatically be deemed canceled, and shall not be reissued.


 


16.           Amendments. The prior written consent of both parties hereto shall be required for any change or amendment to this
Note.


 


17.           Assignments. Borrower may not assign this Note without the prior written consent of Lender. This Note and (subject
to compliance with the provisions hereof and applicable securities laws) any shares of Common Stock issued upon conversion of this
Note may be offered, sold, assigned or transferred by Lender without the consent of Borrower. Lender shall promptly notify Borrower
of any such transfer.


 


18.           Time is of the Essence. Time is expressly made of the essence with respect to each and every provision of this Note
and the documents and instruments entered into in connection herewith.


 


19.           Notices. Whenever notice is required to be given under this Note, unless otherwise provided herein, such notice shall
be given in accordance with the subsection of the Purchase Agreement titled “Notices.”


 


20.           Liquidated Damages. Lender and Borrower agree that in the event Borrower fails to comply with any of the terms or
provisions of this Note, Lender’s damages would be uncertain and difficult (if not impossible) to accurately estimate because
of the parties’ inability to predict future interest rates, future share prices, future trading volumes and other relevant
factors. Accordingly, Lender and Borrower agree that any fees, balance adjustments, or other charges assessed under this Note are
not penalties but instead are intended by the parties to be, and shall be deemed, liquidated damages (under Lender’s and
Borrower’s expectations that any such liquidated damages will tack back to the Purchase Price Date for purposes of determining
the holding period under Rule 144).


 



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21.           Waiver of Jury Trial. EACH OF LENDER AND BORROWER IRREVOCABLY WAIVES ANY AND ALL RIGHTS SUCH PARTY MAY HAVE TO DEMAND
THAT ANY ACTION, PROCEEDING OR COUNTERCLAIM ARISING OUT OF OR IN ANY WAY RELATED TO THIS NOTE OR THE RELATIONSHIPS OF THE PARTIES
HERETO BE TRIED BY JURY. THIS WAIVER EXTENDS TO ANY AND ALL RIGHTS TO DEMAND A TRIAL BY JURY ARISING UNDER COMMON LAW OR ANY APPLICABLE
STATUTE, LAW, RULE OR REGULATION. FURTHER, EACH PARTY HERETO ACKNOWLEDGES THAT SUCH PARTY IS KNOWINGLY AND VOLUNTARILY WAIVING
SUCH PARTY’S RIGHT TO DEMAND TRIAL BY JURY.


 


22.           Voluntary Agreement. Borrower has carefully read this Note and has asked any questions needed for Borrower to understand
the terms, consequences and binding effect of this Note and fully understand them. Borrower has had the opportunity to seek the
advice of an attorney of Borrower’s choosing, or has waived the right to do so, and is executing this Note voluntarily and
without any duress or undue influence by Lender or anyone else.


 


23.           Severability. If any part of this Note is construed to be in violation of any law, such part shall be modified to
achieve the objective of Borrower and Lender to the fullest extent permitted by law and the balance of this Note shall remain in
full force and effect.


 


24.           Par Value Adjustments. If at any time Lender delivers a Conversion Notice to Borrower and as of such date the Conversion
Price would be less than the Par Value, then, as liquidated damages, Company must pay to Lender the Par Value Adjustment Amount
in cash within one (1) Trading Day of delivery of the applicable Conversion Notice (a “Par Value Adjustment”).
If Borrower does not deliver the Par Value Adjustment Amount as required, then such amount shall automatically be added to the
Outstanding Balance. The number of Conversion Shares deliverable pursuant to any relevant Conversion Notice following a Par Value
Adjustment shall be equal to (a) the Conversion Amount, divided by (b) the Par Value. In the event of a Par Value Adjustment, Lender
will use a Conversion Notice in substantially the form attached hereto as Exhibit B.


 


[Remainder of page intentionally left
blank; signature page follows]


 


 






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IN WITNESS WHEREOF,
Borrower has caused this Note to be duly executed as of the Effective Date.


 





 


 


	 	BORROWER:
	 	 
	 	Protea Biosciences Group, Inc.
	 	 
	 	 
	 	By:	 
	 	Name:	 
	 	Title:	 
	 	 	 


 


 


ACKNOWLEDGED, ACCEPTED AND AGREED:


LENDER:


 


St.
George Investments LLC


  


	By:	Fife Trading, Inc., Manager	 
	 	 	 
	 	 	 
	 	By:	 	 
	 	 	John M. Fife, President	 


 







 


 



    [Signature
                                         Page to Convertible Promissory Note]


     


    

 





ATTACHMENT 1


DEFINITIONS


 


For purposes
of this Note, the following terms shall have the following meanings:


 


A1.              
“Bloomberg” means Bloomberg L.P. (or if that service is not then reporting the relevant information regarding
the Common Stock, a comparable reporting service of national reputation selected by Lender and reasonably satisfactory to Borrower).


 


A2.              
“Closing Bid Price” and “Closing Trade Price” means the last closing bid price and
last closing trade price, respectively, for the Common Stock on its principal market, as reported by Bloomberg, or, if its principal
market begins to operate on an extended hours basis and does not designate the closing bid price or the closing trade price (as
the case may be) then the last bid price or last trade price, respectively, of the Common Stock prior to 4:00:00 p.m., New
York time, as reported by Bloomberg, or, if its principal market is not the principal securities exchange or trading market for
the Common Stock, the last closing bid price or last trade price, respectively, of the Common Stock on the principal securities
exchange or trading market where the Common Stock is listed or traded as reported by Bloomberg, or if the foregoing do not apply,
the last closing bid price or last trade price, respectively, of the Common Stock in the over-the-counter market on the electronic
bulletin board for the Common Stock as reported by Bloomberg, or, if no closing bid price or last trade price, respectively, is
reported for the Common Stock by Bloomberg, the average of the bid prices, or the ask prices, respectively, of any market makers
for the Common Stock as reported by OTC Markets Group, Inc., and any successor thereto. If the Closing Bid Price or the Closing
Trade Price cannot be calculated for the Common Stock on a particular date on any of the foregoing bases, the Closing Bid Price
or the Closing Trade Price (as the case may be) of the Common Stock on such date shall be the fair market value as mutually determined
by Lender and Borrower. If Lender and Borrower are unable to agree upon the fair market value of the Common Stock, then such dispute
shall be resolved in accordance with the procedures in Section 14.2. All such determinations shall be appropriately adjusted
for any stock dividend, stock split, stock combination or other similar transaction during such period.


 


A3.              
“Default Effect” means multiplying the Outstanding Balance as of the date the applicable Event of Default
occurred by (a) 15% for each occurrence of any Major Default, or (b) 5% for each occurrence of any Minor Default, and then adding
the resulting product to the Outstanding Balance as of the date the applicable Event of Default occurred, with the sum of the foregoing
then becoming the Outstanding Balance under this Note as of the date the applicable Event of Default occurred; provided that the
Default Effect may only be applied three (3) times hereunder with respect to Major Defaults and three (3) times hereunder with
respect to Minor Defaults; and provided further that the Default Effect shall not apply to any Event of Default pursuant to Section
4.1(b) hereof.


 


A4.              
“DTC” means the Depository Trust Company or any successor thereto.


 


A5.              
“DTC Eligible” means, with respect to the Common Stock, that such Common Stock is eligible to be deposited
in certificate form at the DTC, cleared and converted into electronic shares by the DTC and held in the name of the clearing firm
servicing Lender’s brokerage firm for the benefit of Lender.


 


A6.              
“DTC/FAST Program” means the DTC’s Fast Automated Securities Transfer program.


 


A7.              
“DWAC” means the DTC’s Deposit/Withdrawal at Custodian system.


 


A8.              
“DWAC Eligible” means that (a) Borrower’s Common Stock is eligible at DTC for full services pursuant
to DTC’s operational arrangements, including without limitation transfer through DTC’s DWAC system, (b) Borrower has
been approved (without revocation) by DTC’s underwriting department, (c) Borrower’s transfer agent is approved as an
agent in the DTC/FAST Program, (d) the Conversion Shares that are Rule 144 Eligible are otherwise eligible for delivery via DWAC;
(e) Borrower has previously delivered all Conversion Shares that were Rule 144 Eligible to Lender via DWAC; and (f) Borrower’s
transfer agent does not have a policy prohibiting or limiting delivery of the Conversion Shares that are Rule 144 Eligible via
DWAC.


 






    Exhibit A to Convertible Promissory Note, Page 1


     


    

 


A9.              
“Fundamental Transaction” means that (a) (i) Borrower or any of its subsidiaries shall, directly
or indirectly, in one or more related transactions, consolidate or merge with or into (whether or not Borrower or any of its subsidiaries
is the surviving corporation) any other person or entity, or (ii) Borrower or any of its subsidiaries shall, directly or indirectly,
in one or more related transactions, sell, lease, license, assign, transfer, convey or otherwise dispose of all or substantially
all of its respective properties or assets to any other person or entity, or (iii) Borrower or any of its subsidiaries shall,
directly or indirectly, in one or more related transactions, allow any other person or entity to make a purchase, tender or exchange
offer that is accepted by the holders of more than 50% of the outstanding shares of voting stock of Borrower (not including any
shares of voting stock of Borrower held by the person or persons making or party to, or associated or affiliated with the persons
or entities making or party to, such purchase, tender or exchange offer), or (iv) Borrower or any of its subsidiaries shall,
directly or indirectly, in one or more related transactions, consummate a stock or share purchase agreement or other business combination
(including, without limitation, a reorganization, recapitalization, spin-off or scheme of arrangement) with any other person or
entity whereby such other person or entity acquires more than 50% of the outstanding shares of voting stock of Borrower (not including
any shares of voting stock of Borrower held by the other persons or entities making or party to, or associated or affiliated with
the other persons or entities making or party to, such stock or share purchase agreement or other business combination), or (v) Borrower
or any of its subsidiaries shall, directly or indirectly, in one or more related transactions, reorganize, recapitalize or reclassify
the Common Stock, other than an increase in the number of authorized shares of Borrower’s Common Stock and other than a reverse
split as described in the Company’s definitive proxy statement filed with the SEC on August 14, 2015), or (b) any “person”
or “group” (as these terms are used for purposes of Sections 13(d) and 14(d) of the 1934 Act and the rules and regulations
promulgated thereunder) is or shall become the “beneficial owner” (as defined in Rule 13d-3 under the 1934 Act),
directly or indirectly, of 50% of the aggregate ordinary voting power represented by issued and outstanding voting stock of Borrower.


 


A10.          
“Major Default” means any Event of Default occurring under Sections 4.1(a) (payments), 4.1(k) (Share
Reserve), or 4.1(o) (breach of certain covenants) of this Note.


 


A11.          
“Mandatory Default Amount” means the greater of (a) the Outstanding Balance divided by the Conversion
Price on the date the Mandatory Default Amount is demanded, multiplied by the VWAP on the date the Mandatory Default Amount is
demanded, or (b) the Outstanding Balance following the application of the Default Effect.


 


A12.          
“Market Capitalization” means the product equal to (a) the average VWAP of the Common Stock for the immediately
preceding fifteen (15) Trading Days, multiplied by (b) the aggregate number of outstanding shares of Common Stock as reported on
Borrower’s most recently filed Form 10-Q or Form 10-K.


 


A13.          
“Minor Default” means any Event of Default that is not a Major Default.


 


A14.          
“OID” means an original issue discount.


 


A15.          
“Other Agreements” means, collectively, (a) all existing and future agreements and instruments between,
among or by Borrower (or an affiliate), on the one hand, and Lender (or an affiliate), on the other hand, and (b) any financing
agreement or a material agreement that affects Borrower’s ongoing business operations.


 


A16.          
“Outstanding Balance” means as of any date of determination, the Purchase Price, as reduced or increased,
as the case may be, pursuant to the terms hereof for payment, Conversion, offset, or otherwise, plus the OID, the Transaction Expense
Amount, accrued but unpaid interest, collection and enforcements costs (including attorneys’ fees) incurred by Lender, transfer,
stamp, issuance and similar taxes and fees related to Conversions, and any other fees or charges (including without limitation
Conversion Delay Late Fees) incurred under this Note.


 


A17.          
“Par Value” means the par value of the Common Stock on any relevant date of determination. The Par Value
as of the Effective Date is $0.0001.


 


A18.          
“Par Value Adjustment Amount” means an amount calculated as follows: (a) the number of Conversion Shares
deliverable under a particular Conversion Notice (prior to any Par Value Adjustment) multiplied by the Par Value, less (b) the
Conversion Amount (prior to any Par Value Adjustment), plus (c) $500.00. For illustration purposes only, if for a given Conversion,
the Conversion Amount was $20,000.00, the Conversion Price was $0.0008 and the Par Value was $0.001 then the Par Value Adjustment
Amount would be $5,500.00 (25,000,000 Conversion Shares ($20,000.00/$0.0008) multiplied by the Par Value of $0.001 ($25,000.00)
minus the Conversion Amount of $20,000.00 plus $500.00 equals $5,500.00).


 


A19.          
“Purchase Price Date” means the date the Purchase Price is delivered by Lender to Borrower.


 


A20.          
“Rule 144 Eligible” means Conversion Shares that are eligible for immediate resale without restriction
pursuant to the registration exemption afforded by Rule 144.


 


A21.          
“Trading Day” means any day on which the New York Stock Exchange is open for trading.


 


A22.          
“VWAP” means the volume weighted average price of the Common stock on the principal market for a particular
Trading Day or set of Trading Days, as the case may be, as reported by Bloomberg.


 






    Exhibit
A to Convertible Promissory Note, Page 2


     


    

 


EXHIBIT A


 





St. George Investments LLC


303 East Wacker Drive, Suite 1040


Chicago, Illinois 60601


 


	Protea Biosciences Group, Inc.	Date:                                 


Attn: Stephen Turner, CEO


1311 Pineview Drive, Suite 501


Morgantown, West Virginia 26505


 


CONVERSION NOTICE


 


The above-captioned
Lender hereby gives notice to Protea Biosciences Group, Inc., a Delaware corporation (the “Borrower”), pursuant
to that certain Convertible Promissory Note made by Borrower in favor of Lender on March 4, 2016 (the “Note”),
that Lender elects to convert the portion of the Note balance set forth below into fully paid and non-assessable shares of Common
Stock of Borrower as of the date of conversion specified below. Said conversion shall be based on the Conversion Price set forth
below. In the event of a conflict between this Conversion Notice and the Note, the Note shall govern, or, in the alternative, at
the election of Lender in its sole discretion, Lender may provide a new form of Conversion Notice to conform to the Note. Capitalized
terms used in this notice without definition shall have the meanings given to them in the Note.







		A.	Date of Conversion: ____________



		B.	Conversion #: ____________



		C.	Conversion Amount: ____________



		D.	Conversion Price: _______________



		E.	Conversion Shares: _______________ (C divided by D)



		F.	Remaining Outstanding Balance of Note: ____________*



 


* Subject to adjustments for corrections,
defaults, interest and other adjustments permitted by the Transaction Documents (as defined in the Purchase Agreement), the terms
of which shall control in the event of any dispute between the terms of this Conversion Notice and such Transaction Documents.


 


Please transfer the Conversion Shares
electronically (via DWAC) to the following account:


	Broker:	 		Address:	 
	DTC#:	 	 	 	 
	Account #:	 	 	 	 
	Account Name:	 	 	 	 




 


To the extent the
Conversion Shares are not able to be delivered to Lender electronically via the DWAC system, deliver all such certificated shares
to Lender via reputable overnight courier after receipt of this Conversion Notice (by facsimile transmission or otherwise) to:


_____________________________________


_____________________________________


_____________________________________


 


 


 


[Remainder of page intentionally left
blank; signature page follows]


 


 






    Exhibit
A to Convertible Promissory Note, Page 3


     


    

 





Sincerely,


 


Lender:


 


St.
George Investments LLC







 





	By:	Fife Trading, Inc., Manager	 
	 	 	 
	 	 	 
	 	By:	 	 
	 	 	John M. Fife, President	 


 






    Exhibit
A to Convertible Promissory Note, Page 4


     


    

 





EXHIBIT B


 





St. George Investments LLC


303 East Wacker Drive, Suite 1040


Chicago, Illinois 60601










 








	Protea Biosciences Group, Inc.	 	Date:
__________________


Attn: Stephen Turner, CEO


1311 Pineview Drive, Suite 501


Morgantown, West Virginia 26505


 


CONVERSION NOTICE


 





The above-captioned
Lender hereby gives notice to Protea Biosciences Group, Inc., a Delaware corporation (the “Borrower”), pursuant
to that certain Convertible Promissory Note made by Borrower in favor of Lender on March 4, 2016 (the “Note”),
that Lender elects to convert the portion of the Note balance set forth below into fully paid and non-assessable shares of Common
Stock of Borrower as of the date of conversion specified below. Said conversion shall be based on the Conversion Price set forth
below. In the event of a conflict between this Conversion Notice and the Note, the Note shall govern, or, in the alternative, at
the election of Lender in its sole discretion, Lender may provide a new form of Conversion Notice to conform to the Note. Capitalized
terms used in this notice without definition shall have the meanings given to them in the Note.










		A.	Date of Conversion: ____________



		B.	Conversion #: ____________



		C.	Conversion Amount: ____________



		D.	Par Value Adjustment Amount: _______________



		E.	Conversion Price: _______________ (Par Value)



		F.	Conversion Shares: _______________ (C divided by E)



		G.	Remaining Outstanding Balance of Note: ____________*



 


* Subject to adjustments for corrections,
defaults, interest and other adjustments permitted by the Transaction Documents (as defined in the Purchase Agreement), the terms
of which shall control in the event of any dispute between the terms of this Conversion Notice and such Transaction Documents.


 


Please transfer the Conversion Shares
electronically (via DWAC) to the following account:





	Broker:	 		Address:	 
	DTC#:	 	 	 	 
	Account #:	 	 	 	 
	Account Name:	 	 	 	 


 





To the extent the Conversion Shares are
not able to be delivered to Lender electronically via the DWAC system, deliver all such certificated shares to Lender via reputable
overnight courier after receipt of this Conversion Notice (by facsimile transmission or otherwise) to:


_____________________________________


_____________________________________


_____________________________________


 


 


The Par Value Adjustment Amount must be
paid in cash within one (1) Trading Day of your receipt of this Conversion Notice.


 


 


[Remainder of page intentionally left
blank; signature page follows]


 






    


Exhibit B to Convertible Promissory Note,
Page 1







     


    

 


 








Sincerely,


 


Lender:


 


St.
George Investments LLC







 





	By:	Fife Trading, Inc., Manager	 
	 	 	 
	 	 	 
	 	By:	 	 
	 	 	John M. Fife, President	 


 



 


 






    
Exhibit B to Convertible Promissory Note, Page 2