| **STATEMENTS OF OPERATIONS (Unaudited) (USD $)In Thousands, except Per Share data** | 3 Months Ended | 9 Months Ended |
|-------------------------------------------------------------------------------------|----------------|----------------|
||
| **Revenues:**                                                                       |           |           |   |   |
| Collaboration revenue                                                               | $ 2,855        | $ 82           | $ 76,398 | $ 1,175 |
| Royalty income                                                                      | 1,240          | 620            | 1,767 | 1,826 |
| Research grants                                                                     | 1,681          | 1,234          | 4,346 | 2,667 |
| Other revenues                                                                      | 28             | 31             | 88 | 127 |
| Total revenues                                                                      | 5,804          | 1,967          | 82,599 | 5,795 |
| **Expenses:**                                                                       |           |           |   |   |
| Research and development                                                            | 12,406         | 12,967         | 44,887 | 35,518 |
| License fees - research and development                                             | 114            | 110            | 566 | 1,217 |
| General and administrative                                                          | 4,064          | 5,414          | 14,213 | 17,568 |
| Royalty expense                                                                     | 147            | 62             | 274 | 182 |
| Depreciation and amortization                                                       | 520            | 532            | 1,581 | 2,283 |
| Total expenses                                                                      | 17,251         | 19,085         | 61,521 | 56,768 |
| Operating income (loss)                                                             | (11,447)       | (17,118)       | 21,078 | (50,973) |
| **Other income:**                                                                   |           |           |   |   |
| Interest income                                                                     | 15             | 17             | 49 | 48 |
| Total other income                                                                  | 15             | 17             | 49 | 48 |
| Net income (loss)                                                                   | $ (11,432)     | $ (17,101)     | $ 21,127 | $ (50,925) |
| Net income (loss) per share - basic                                                 | $ (0.34)       | $ (0.52)       | $ 0.63 | $ (1.57) |
| Weighted-average shares - basic                                                     | 33,710         | 32,814         | 33,501 | 32,444 |
| Net income (loss) per share - diluted                                               | $ (0.34)       | $ (0.52)       | $ 0.63 | $ (1.57) |
| Weighted-average shares - diluted                                                   | 33,710         | 32,814         | 33,664 | 32,444 |

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The amount of net income or loss for the period per each share of common stock outstanding during the reporting period; and the amount of net income or loss for the period per each share of common stock and dilutive common stock equivalents outstanding during the reporting period.
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| - Definition
Revenue earned during the period from non-repayable sum of money awarded to an entity to carry out a specific purpose as provided in grant agreements, combined with the revenue earned during the period arising from products sold or services provided under the terms of a contract, not elsewhere specified in the taxonomy. May include government contracts, construction contracts, and any other contract related to a particular project or product.
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| - Definition
Number of [basic] shares, after adjustment for contingently issuable shares and other shares not deemed outstanding, determined by relating the portion of time within a reporting period that common shares have been outstanding to the total time in that period; and the average number of shares issued and outstanding that are used in calculating diluted EPS, determined based on the timing of issuance of shares in the period.
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| - Definition
Cost of generating revenue from multiple-deliverable arrangements that include licensing fees and services revenue. Licensing revenue is consideration received from another party for the right to use, but not own, certain of the entity's intangible assets. Licensing arrangements include, but are not limited to, rights to use a patent, copyright, technology, manufacturing process, software or trademark. Licensing fees are generally, but not always, fixed as to amount and not dependent upon the revenue generated by the licensing party. An entity may receive licensing fees for licenses that also generate royalty payments to the entity. Services revenue may be derived by providing other, nonspecified, services during the reporting period.
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Total costs of sales and operating expenses for the period.
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The aggregate expense recognized in the current period that allocates the cost of tangible assets, intangible assets, or depleting assets to periods that benefit from use of the assets.
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| - Definition
The amount of net income or loss for the period per each share of common stock outstanding during the reporting period.
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The aggregate total of expenses of managing and administering the affairs of an entity, including affiliates of the reporting entity, which are not directly or indirectly associated with the manufacture, sale or creation of a product or product line.
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| - Definition
Income derived from investments in debt securities and on cash and cash equivalents the earnings of which reflect the time value of money or transactions in which the payments are for the use or forbearance of money.
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| - Definition
The portion of consolidated profit or loss for the period, net of income taxes, which is attributable to the parent. If the entity does not present consolidated financial statements, the amount of profit or loss for the period, net of income taxes.
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| - Definition
The aggregate amount of income (expense) from ancillary business-related activities (that is to say, excluding major activities considered part of the normal operations of the business).
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The net result for the period of deducting operating expenses from operating revenues.
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| - Definition
Revenues from the sale of other goods or rendering of other services, not elsewhere specified in the taxonomy; net of (reduced by) sales adjustments, returns, allowances, and discounts.
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| - Definition
The costs incurred in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, excluding in-process research and development acquired in a business combination consummated during the period. Excludes software research and development, which has a separate concept.
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Amount of expense related to royalty payments under a contractual arrangement such as payment for mineral and drilling rights and use of technology or intellectual property.
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| - Definition
Revenue earned during the period from the leasing or otherwise lending to a third party the entity's rights or title to certain property. Royalty revenue is derived from a percentage or stated amount of sales proceeds or revenue generated by the third party using the entity's property. Examples of property from which royalties may be derived include patents and oil and mineral rights.
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| - Definition
Total revenue from sale of goods and services rendered during the reporting period, in the normal course of business, reduced by sales returns and allowances, and sales discounts.
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