Federal Register / Vol. 76, No. 47 / Thursday, March 10, 2011 / Notices 13195 

koelblep@nhlbi.nih.gov for more 

information. 

Active Adaptive Detuning Systems To 

Improve Safety of Interventional 

Devices 

Description of Invention: The 

invention offered for licensing and 

commercial development is in the field 

of Interventional Magnetic Resonance 

Imaging (‘‘iMRI’’). More specifically the 

invention discloses interventional 

devices in which the heat generated at 

the device during the imaging process 

can be controlled to not exceed 

acceptable levels. 

Active MRI compatible intravascular 

devices contain RF antenna so that they 

are visible under MRI. However, these 

metallic structures may heat up 

significantly during interventional MRI 

procedures due to eddy current 

formation over the conductive 

transmission lines. The electrical field 

coupling between interventional devices 

and RF transmission coils strongly 

depend on the device position and 

orientation within the bore and 

insertion length of the device. Currently, 

conventional detuning circuit is used to 

decouple the conductive intravascular 

device during RF transmission phase of 

the MRI by activating the circuit with a 

PIN diode. However, conventional 

passive techniques do not adapt for each 

possible orientation or insertion length 

of the device. The current invention 

provides for a new active detuning 

system that adapts its circuit component 

to limit heating for every possible 

orientation and insertion length. The 

system reads out the received current 

signal value during RF transmission 

phase and changes the decoupling 

capacitor value by using varactor and 

integrated circuit components to reach 

new resonant condition (very high 

impedance). 

Applications: 

• Interventional cardiology 

• MRI guided surgery 

Advantages: The device may 

fundamentally enable any ‘‘active’’ MRI 

catheter device (independent of the 

orientation and insertion length of the 

device) to be safe during real-time MRI 

guided interventional procedures. 

Development Status: In development. 

Prototype is being built. 

Inventors: Ozgur Kocaturk (NHLBI). 

Patent Status: U.S. Provisional 

Application No. 61/360,998 filed 07 Jul 

2010 (HHS Reference No. E–114–2010/ 

0–US–01) 

Relevant Publication: Overall WR, 

Pauly JM, Stang PP, Scott GC. Ensuring 

safety of implanted devices under MRI 

using reversed RF polarization. Magn 

Reson Med. 2010 Sep;64(3):823–833. 

[PubMed: 20593374] 

Licensing Status: Available for 

licensing. 

Licensing Contact: 

• Uri Reichman, PhD, MBA; 301– 

435–4616; UR7a@nih.gov. 

• Michael Shmilovich, Esq.; 301– 

435–5019; ShmilovichM@mail.nih.gov. 

Collaborative Research Opportunity: 

The National Heart, Lung, and Blood 

Institute is seeking statements of 

capability or interest from parties 

interested in collaborative research to 

further develop, evaluate, or 

commercialize this technology. Please 

contact Peg Koelble at 

koelblep@nhlbi.nih.gov for more 

information. 

Dated: March 4, 2011. 

Richard U. Rodriguez, 

Director, Division of Technology Development 

and Transfer, Office of Technology Transfer, 

National Institutes of Health. 

[FR Doc. 2011–5511 Filed 3–9–11; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

National Institute of Allergy and 

Infectious Diseases; Notice of Closed 

Meeting 

Pursuant to section 10(d) of the 

Federal Advisory Committee Act, as 

amended (5 U.S.C. App.), notice is 

hereby given of the following meeting. 

The meeting will be closed to the 

public in accordance with the 

provisions set forth in sections 

552b(c)(4) and 552b(c)(6), Title 5 U.S.C., 

as amended. The grant applications and 

the discussions could disclose 

confidential trade secrets or commercial 

property such as patentable material, 

and personal information concerning 

individuals associated with the grant 

applications, the disclosure of which 

would constitute a clearly unwarranted 

invasion of personal privacy. 

Name of Committee: National Institute of 

Allergy and Infectious Diseases Special 

Emphasis Panel; Mouse Models of Host 

Responses. 

Date: April 5, 2011. 

Time: 1 p.m. to 5 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: National Institutes of Health, 6700B 

Rockledge Drive, Bethesda, MD 20817. 

Contact Person: Brandt Randall Burgess, 

PhD, Scientific Review Officer, Scientific 

Review Program, Division of Extramural 

Activities, DHHS/NIH/NIAID, 6700B 

Rockledge Drive, MSC 7616, Bethdesda, MD 

20892, 301–451–2584, 

bburgess@niaid.nih.gov. 

(Catalogue of Federal Domestic Assistance 

Program Nos. 93.855, Allergy, Immunology, 

and Transplantation Research; 93.856, 

Microbiology and Infectious Diseases 

Research, National Institutes of Health, HHS) 

Dated: March 4, 2011. 

Jennifer S. Spaeth, 

Director, Office of Federal Advisory 

Committee Policy. 

[FR Doc. 2011–5505 Filed 3–9–11; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

Center for Scientific Review; Notice of 

Closed Meetings 

Pursuant to section 10(d) of the 

Federal Advisory Committee Act, as 

amended (5 U.S.C. App.), notice is 

hereby given of the following meetings. 

The meetings will be closed to the 

public in accordance with the 

provisions set forth in sections 

552b(c)(4) and 552b(c)(6), Title 5 U.S.C., 

as amended. The grant applications and 

the discussions could disclose 

confidential trade secrets or commercial 

property such as patentable material, 

and personal information concerning 

individuals associated with the grant 

applications, the disclosure of which 

would constitute a clearly unwarranted 

invasion of personal privacy. 

Name of Committee: Center for Scientific 

Review Special Emphasis Panel; 

Fellowships: AIDS Predoctoral and 

Postdoctoral. 

Date: March 29, 2011. 

Time: 11 a.m. to 7 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: New York Marriott East Side, 525 

Lexington Avenue at 49th Street, New York, 

NY 10017. 

Contact Person: Shiv A Prasad, PhD, 

Scientific Review Officer, Center for 

Scientific Review, National Institutes of 

Health, 6701 Rockledge Drive, Room 5220, 

MSC 7852, Bethesda, MD 20892, 301–443– 

5779, prasads@csr.nih.gov. 

Name of Committee: Center for Scientific 

Review Special Emphasis Panel; Member 

Conflict Computational Genetics and 

Genomics. 

Date: March 29, 2011. 

Time: 3 p.m. to 5 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: National Institutes of Health, 6701 

Rockledge Drive, Bethesda, MD 20892 

(Telephone Conference Call). 

Contact Person: Malgorzata Klosek, PhD, 

Scientific Review Officer, Center for 

Scientific Review, National Institutes of 

Health, 6701 Rockledge Drive, Room 4188, 

MSC 7849, Bethesda, MD 20892, (301) 435– 

2211, klosekm@csr.nih.gov. 


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