### U.S. ENVIRONMENTALPROTECTIONAGENCY 

## PREMANUFACTURE NOTICE :S

1\.1;;1 UlII:' UJta.1 uUll.lVQ.l V.l pa5"';:} 

# ........ inthe Premanufac1ureNotice Form 

### AGENCY USE ONLY Date Dfreceipt



## Company Sanitized

GENERALINSTRUCTIONS You mustprovide all infonnationrequested inthis form to the extentthat it is knownto orreasonably ascertainable byyou. Make reasonable estimates ifyou do not have actual data. Before you complete this form, you should read the "InstructionsManual for Premanufacture Notification" (the Instructions Manualis availablefrom the Toxic SubstancesControl Act (TSCA) Information Service by calling 202-554-1404, orfaxing 202-554-5603). Ifa user fee has beenremitted for this notice (40 CFR700.45), indicate inthe boxes above the TS-userfee identificationnumber youhave generated. Remember, youruser fee ID number must also appear onyour correspondingfee remittance, which is sent to EPA, HQ Accounting OperationsBranch (PM-226), P.O. 360399M,Pittsburgh, PA 15251-6399, Attn. TSCAUser fee. Part**I~** GENERAL INFORMATION You must provide the currently correct Chemical Abstracts (CA) Name ofthe new chemical substance, even ifyou claimthe identity as confIdentiaL You may authorize another person to submit chemical identity information for you, butyoursubmIssion will not be complete and the review will not begin until EPA receives this information A letter in support ofyour submission should reference your TS user fee identifIcation number. You must submit an original and two copies ofthis notice including all test data Ifyou claimed any information as con:tidential, a single sanitized copy must also be submitted
Part II HUMAN EXPOSURE AND ENVIRONMENTAL RELEASE Ifthere are several manufacture, processing, or use operations to be described inPart II, sections A and B ofthisnotice, reproduce the sections as needed.

Part III LIST OF ATTACHMENTS Attach additional sheets ifthere is not enough space to answer a question fully. Label each continuation sheetwiththe corresponding section heading. In Part III, list these attachments, any test data orother data and any optional informationincluded in the notIce.

OPTIONAL INFORMATION You may include any information that you want EPA to consider in evaluating the new substance. On page 11 ofthis fonn, space has beenprovided for you to described pollution prevention and recycling informationyou may have regarding the new substance. So-called "binding" boxes are included throughoutthis form for you to indicateyour willingness to be bound to certain statementsyou make in this section, such as use, production volume, protective equipment. This optionis intended to reduce delays that routinely accompany the development ofconsent orders or SignifIcant New Use Rules. Except in the case ofexemption applications (such as TMEA, LVE, LOREX) where certaininformation provided in such notification is binding onthe submitter when the Agency approves the exemption application, checking a binding box in this notice does not by itselfprohibIt the submitterfrom later deviating from the information (except chemical identity) reported in the form.
CONFIDENTIALITY CLAIMS You may claim any information in this notice as confidential. To assert a claim onthe fonn, mark (X) the confIdential box next to the informationthatyou claim as confidential. To assert a claimin an attachment, circle orbracketthe informationyou claim as confidentiaL Ifyou claiminformation in the notices.as confidential youmust also provide a sanitizedversion ofthe notice (including attachments). For additional instructions on claimIng information as confidential, read the Instructions Manual. 

# k8J Mark (x)ifany informationinthis notice is claimed as confidential. TESTDATA AND OTHER DATA You are required to submit all test data inyourpossession or control and to provide a description ofall other dataknown to or reasonably ascertainable by you, ifthese data are related to the health and environmental effects on the manufacture, processing, distribution in commerce, use, or disposal ofthe neW chemical substance. Standard literature citations may be submitted for data in the open scientific literature. Complete testdata (written inEnglish), not summaries ofdata, mustbe submitted ifthey do not appear inthe open literature. You should clearly identify whether testdata is onthe substance or on an analog. Also, the chemical composition ofthe tested material shouldbe characterized. Following are examples oftest data and otherdata. Data should be submitted according to the requirements of§720.50 ofthe PremanufactureNotification Rule (40 CFRPart 720).

TestData (Check Below any included inthis notice) Environmental fate data 

### 181 Yes Other data 

### 181 Yes Health effects data 

### 181 Yes Risk assessments Environmental effects data 

### 181 Yes Structure/activityrelationships Physical/Chemical Properties. 

### 181 Yes Test data notinthepossessIOn or control ofthe submitter
• A pbysical and chemical properties worksheet is located on the lastpage ofthis fonn. TYPE OF NOTICE (Check Only One)

### ~ PMN (Premanufacture Notice) 

# D INTERMEDIATE PMN (submitted in sequence with final product PMN) 

# D SNUN (Significant New Use Notice) 

# D TMEA (TestMarketing Exemption Application) 

# D LVE (Low Volume Exemption)@40 CFR 

# D LOREX (LowRelease/Low ExposureExemption) @

### 4Q~R n3.50(c){2) 

# D 

# D LVE Modification LOREX Moctif!liation IS THIS A CONSOLIDATED PMN? Yes 

# D
# ofchemicals (Prenotice Communication# required, enter# onpage 3)**~DAFORM7710-25** (Rev. 5-95) Replaces previous editions ofEPA Form 7710-25. 

# IIB"V:' _IDENTIAl8USINOI INFORMATION 

# JPublic reporting burdenfor this collection ofinformation is estimated to average 110 hours perresponse, including time tor reviewing instructions, searching existing data sources, gathering andmaintaining the data needed, andcompleting andreviewing the collection of information. Sendcomments regarding the burden estimate orany other aspect ofthis collection ofinformation, including suggestions for reducing this burden, to Cruet: Information Policy Branch, PM-223, U.S. Environmental Protection Agency, 401 M St, S.W., Washington, D.C. 20460; andto the Office oCManagement and Budget, Paperwork ReductionAct (2070-0012), Washington, D.C. 20503. 

## CERTIFICATION I certify thatto the best ofmy knowledge and belief: 1. The company named in Part I, section A, subsection laofthis notice form intends to manufacture or import for a commercial pwpose, other than in small quantities solely for research and development, the substance identified in Part I, Section B. 2. All information provided in this notice is complete and truthful as ofthe date ofsubmission. 3. I am submitting withthis notice all test data in my possession or control and a description ofall other data known to or reasonably ascertainable by me as required by §720.50 ofthe Premanufacture Notification Rule.
Additional Certification Statements: If

### you are submittinga PMN, Intermediate PMN, Consolidated PMN, or SNUN, checkthe following userfee certification statementthat applies: 

## (8J The Company named in Part I, Section A has 

### remitted the fee of$2500 specified in 40 CFR 700.45(b), or 

# o The Company named in Part I, Section A has remitted the fee of$1000 for an Intermediate PMN (defined 

### @40 CFR 700.43) in accordance with 40 CFR 700.45(b), or 

# o The Company named in Part I Section A is a small business concernunder 40 CFR 700.43 and has remitted a fee ofS1OO in accordance with 40 CFR 700.45(b). If

### you are submittinga low volume exemption (LYE) application in accordance with 40 CFR 723.50(c)(I) or a Low release and low exposure exemption (LoRex) application in accordance with 40 CFR 723.50(c)(2), check the following certification statements: 

# o The manufacturer submitting this notice intends to manufacture or import the new chemical substance for commercial purposes, other than in small quantities solely for research and development, under the terms of40 CFR723.50. 

# oThe manufacturer is familiar with the terms ofthis section and will comply with those terms; and 

# o The new chemical substance for which the notice is submitted meets all applicable exemption conditions. 

# o If

### this applicationis for an LVE in accordance with 40 CFR 723.50(c)(1), the manufacturer intends to commence manufacture ofthe exempted substance for commercial pwposes within 1year ofthe date ofthe expiration ofthe 30 day review period.

Conndential

Signature ofagent
- (ifapplicable) Date

EPA FORM7710-25 (Rev. 5-95) Page 2la. Person Submitting Notice (in U.S.)

b. Agent (if applicable) Company Industries Inc. Mailmgaddress (numberand street) aza 

### NJ amnO)rtZf:a official
Company
Mailingaddress (number and street)
City, State, ZIP Code

c. Ifyou are submittingthis notice as part submission, mark Joint Submitter (if applicable)

2.

3. Contact (in U.S.) Company
street)
City, State, ZIP Code

Name of
Company CYTEC Industries Inc. Mailingaddress (numberand street) 

### 5 City, State, ZIP Code West Paterson, 

### NJ 07424 Ifyou have had a prenotice conununication concerningthis notice and EPA assigned a PC Number to the notice, enterthe number. Telephone box.

______________________________________**~**

Telephone

Position Americas

Telephone

Mark (X)**~**

### ~ ifnone
Mark(X) 

# .. ifnone 4. Ifyou previously submitted anexemption application for the chemical substance covered by this notice, enter the exemptionnumber assigned by EPA Ifyoupreviously submitted a PMN for this substance enter the PMNnumber assigned by EPA (i.e. withdrawn or incomplete). .. 5. for the chemical substance covered bythis notice, enterthe notice number assigned by EPA. .. 1. Manufacture 6. Type ofNotice

- Mark (X) Only 

# D Binding Option Mark Mark(X) 

# .. ifnone 2. Import Only 3. Both 

# D Binding Option Mark 

# D

EPA FORM 7710-25 (Rev. 5·95) Page 31. Complete eitheritem I (Class I or 2 substances) or2 (Polymers) asappropriate. Complete all otheritems.

a. Class ofsubstance·Mark (X) or Instructions Manual) Class 2 ,-,,,,eHlI'''''' name correct Abstracts (CA) Namethat is consistent with TSCAInventory listings substances. For Class I substances a CAIndexName must be provided. ForClass 2 substances either a CAIndexName or CAPreferred Name must be provided, which ever is appropriate based onCA 9CI nomenclature rules andconventions).

c. Please you used to develop or notice: (check one). 

## r:8J Method I (CAS Inventory Expert Service a copy ofthe Identification 

# 0 Method 2 (Other Source) report obtainedfrom the CAS Inventory Expert Services must be submitted asan attachmenttothis d Molecular formula and CAS Registry Number (ifa number already exists for the substance)

e. For a class 1 substance, provide a complete and correct chemical structure diagram. For a class 2 substance

- (1) Listthe immediate precursor substances withtheirrespective CAS Registry Numbers. (2) Describethe nature ofthe reaction orprocess. (3) Indicatethe range ofcomposition andthetypical composition (where appropriate). (4) Provide a correctrepresentative orpartial chemical structure diagram, as complete as can be known, ifone can be reasonably ascertained. basedon

Confi· dential



# x 

# x

x
x


# x



# o Mark (X) this box ifyou attach a continuation sheet.

EPA FORM 7710·25 (Rev. 5·95) Page 42. Confi­ Polymers (For a definition ofpolymer, see the Instructions Manual.) 

### NotApplicable rNA) dential a. Indicate the number-average weight ofthe lowestmolecular weight composition ofthepolymer you intendto manufacture. Indicate maximum weightpercent oflow molecular weight species (not including residual monomers, reactants, or solvents) below 500 and below 1,000 absolute molecular weight ofthat composition. Describe the methods ofmeasurement or the basis for your estimates: GPC

# 0 Other 

# 0: (Specify) i) lowest numberaverage molecular weight: ii) maximum weight % below 500 molecular weight: iii) maximum weight % below 1000 molecular weight:

You must make separate attach a continuation sheet. claims for monomer or otherreactant identity, composition information, andresidual information. Mark (X) "Confidential" box next to any item you claim as confidential (1)

- Providethe specific chemical name and CAS Registry Number (ifa number exists) ofeach monomer or otherreactant used inthe manufacture of the polymer. (2) Mark (X)this columnifentry in column (1) is confidential. (3) Indicate thetypical weight percent ofeach monomer orother reactant inthe polymer. (4) Mark (X)the identity column ifyou want a monomer or otherreactant used attwo weight percent or less to be listed as part ofthe polymer desLTiption onthe TSCAChemical Substance Inventory. (5) Mark (X) this column ifentries in columns (3) and (4) are confidential. (6) Indicate the maximum weight percent ofeach monomer or otherreactantthatmay be present as a residual inthe polymer as manufactured for commercial purposes.
applicable

### to this PMN % % % % % % % % % % % % Mark this columnif is confidential. Maximum

Please identify which method you used to develop or obtainthe specified chemical identity informationreported inthis notice (check one). Method 2 (other source)

one can be reasonably ascertained.

Page 5 c. 

# oMethod 1 (CAS Inventory Expert Service - a copy ofthe identification report 

# 0 obtained from CAS Inventory Expert Service must be submitted as as attachment to this d. The currently correct Chemical Abstracts (CA) name for the polymerthatis consistent with TSCA Inventory

e. Provide a correctrepresentative or partial chemical structure diagram, as complete as can be known,

Mark (X)this boxifyou attach a continutation sheet

EPA FORM 7710-25 (Rev. 5-95)(a) Identify eachimpuritythat may bereasonably anticipated to be present inthe chemical substance as manufactured for commercia! purpose. Provide the CAS Registry Number ifavailable. Ifthere areunidentified impurities, enter "unidentified." Estimatethe maximum % ofeach' Ifthere are unidentified' estimatetheirtotal

4. Synonyms

- Enter any chemical synonyms for the new chemical identified in subsection I or 2. 

# o Mark (X)this box ifyou attach a continuation sheet. 5. Trade identification Listtrade names for the new chemical substance identified in subsection I or2. 

### AERO® 5715 Promoter 

# o Mark (X) this box ifyou attach a continuation sheet. 6. Generic chemical name ­ claim chemical dential, you must provide a generic name for your substancethatreveals the specific chemical identity ofthenew chemical substanceto the maximum extentpossible. Refertothe TSCAChemical Substance Inventory, 1985 Edition, Appendix B for guidance on developing generic names. 

### Thionocarbamate derivative or modified thionocarbamate.

this box ifyou attach a continuation sheet. %

%

%

% dential 

# x 

# x x

Confidential



## x

Describe any byproducts from the manufacture, processing,use, or new chemical substance. Providethe CAS Registry Numberifavailable. 

### None

Mark (X)this box ifyou attach a continuation sheet.

EPA FORM 7710-25 (Rev. 5-95) CAS

Page 6 Number Confidential

## Part I

-- GENERAL INFORMATION

-- Continued
• Section C

-- PRODUCTION. IMPORT, AND USE INFORMATION: Mark (X) the "Confidential" box nextto any itemyou claim as confidential. 1. Production volume

­ Estimatethe maximumproduction volume during the first 12 months ofproduction. Also estimatethe maximum production volume for any consecutive 12-month period during the first three years ofproduction. Estimates shouldbe on 100%newchemical substance basis. For a Low Volume Exemption application, ifyou choose to have your notice reviewed at a lowerproduction volume than IO,O(}O kglyr, specifythe volume andmark (x) inthe bindingbox. Ifgranted, you are boundtothis volume Maximumflrst 12-monthproduction (kglyr) Maximum 12-monthproduction (kglyr) Confi- Binding I (100%new chemical substancebasis) (100%new chemical substance basis) dential Option Mark (x) 

### X 2. Use Information

-- You mustmake separate confidentiality claims for the description ofthe category ofuse, thepercentofproduction volume devoted to eachcategory, the formulation of the new substance, and otheruse information. Mark (X)the "Confidential" Box nextto any item you claim as confidential. a. (1)

-­ Describe eachintendedcategory ofuse ofthe newchemical substance by function and application
.. (2)

­ Mark (X)this columnifentry column (1) isconfidential business information (CEl). (3)­ Indicate your willingness to have the informationprovidedin column (I)binding. (4) Estimatethe percentoftotalproduction for the first three years devoted to eachcategory ofuse. (5)

-­ Mark (X)this columnifentry in column (4) is confidentialbusiness information (CEl). (6)

-­ Estimatethepercent ofthenew substance as formulated inmixtures, suspensions, emulsions, solutions, orgels asmanufactured for commercialpurposes at sitesunder your control associated with each category ofuse. (7)

-­ Mark (X)this column ifentry in column (6) is confidential business information (CBl). (8) Indicate % ofproductvolume expected for the listed "use" sectors. Markmore than one boxifappropriate. Mark eX) to indicate your willingnessto have the use type providedin (8)binding. (9)

-­ Mark eX)this column ifentry(ies) incolumn (8)is (are) confidentialbusiness information (CBI). Category ofuse (I) CBI Bindin Produc- CBI %in CBI % ofsubstance expectedperuse CBI g tion% Form­ (8) Option (by function and application i.e. a dispersive dye Mark ulation Site- Con-* Indus- Com- Binding for finishing polyester fibers) (2) (x) (4) (5) (6) (7) limited sumer trial mercial Option (9) (3) 

### X X X X % % % % % % % % % % % % 

### * Ifyou have identified a "consumer" use, please provide on a continuation sheet a detailed description ofthe use(s) ofthis chemical substance in consumer products.

In addition include estimates ofthe concentration ofthenew chemical substance as expected in consumer products and deseribe the chemical reactions by whichthis substance loses its identity in the consumerproduct. DMark(X)this boxifyou attach a continuation sheet. b. Generic Ifyou claim any category ofuse deseription in subsection 2aas confidential, entera generic description ofthatcategory, Read the use**Instru~"tions** Manual for examples ofgeneric use descriptions. description 

### Sulfide Mineral Processing Reagent



# D Mark (X)this boxifyou attach a continuation sheet. 3. Hazard Information Includeinthe notice a copy ofreasonable facsimile ofany hazard warning statement, label, material safety data sheet, or other Binding

information which will be providedto anyperson who is reasonably likelytobe exposedtothis substance regarding protective equipment or practices Option fOfthe safe handing, transport, use, ordisposal ofthe new substance. List in partIII hazard information you include. Mark (x)

Mark (X) this box ifyou attach hazard information. 

## See Attachments 1 and 2: MSDS and Label.

EPAFORM 7710-25 (Rev. 5-95) Page 7

## Part ll-­ Complete section A for eachtype ofmanufacture, processing, or use operation involving the newchemical substance atindustrial sites you you
control. Importers do nothaveto complete this section for operations outsidethe US.; however, you may still havereporting requirements if there are further industrial
. or use . after' You mustdescribe these
. See instructionsmanual I. ofthe site at "Whichthe will occur. Name 

### This substance will be imported. See below Site address (number and street) City, County, State, ZIP code
Ifthe sameoperationwill occur atmorethanone slte, enterthe number ofSIteS. Identify the additional sites on a continuation sheet, andifany ofthe siteshave significantly different productionrates or operations, include all the informationrequestedinthis sectionfor those sites asattachments.

1. Batch

2. Continuous Maximumkgtbatch (100%new chemical Hourslbatch substance)
d. Process description Mark (X) to indicate your willingness to have your process description binding. Use Batches/year
Batches/year

(1) Diagramthe major unit operation steps and chemical conversions. Includeinterim storage andtransport containers (specify- e.g. 5 gallon pails, 55 gallon drum, rail car, tanktruck, etc.). (2) Providethe identity,the approximate weight (by kg/day or kg/batch on a 100%new chemical substance basis), and entry point ofaU starting materials and feedstocks (includingreactants, solvents, catalysts, etc.), and ofall products, recycle streams, and wastes. Include cleaning chemicals (note frequency ifnot used daily orperbatch.). (3) Identify by numberthe points ofrelease, including small or intermittent releases, tothe environment ofthenew chemical substance. 

### The information requested on this page does not apply for this substance because it is imported. None is manufactured in the U.S. by the submitter. The product will be imported either to a warehouse or directly to the customer mine site. The manufacturer's quality control data will be used and reported routinely



# D Mark (X)this boxifyou attacha continuation sheet.

EPA FORM 7710-25 (Rev. 5-95) PageS

# I Part TI-- HUMAN EXPOSURE AND ENVIRONMENTAL RELEASE

-- Continued Section A

-- INDUSTRIAL SITES CONTROLLED BY THE SUBMITTER

- Continued 2. OccupationalExposure You must make separate confidentiality claims for the description ofworker activity, physical form ofthe new chemical substance, number ofworks exposed, and duration ofactivity. Mark (X)the "Confidential" box nextto any itemyou claim as confidential. (I) •• Describe the activities (i.e. bag dumping, tote filling, unloading drums, sampling, cleaning, etc.) in which workers may be exposedtothe substance. (2) •• Mark (X)this columnifentry in column (I) is confidential business information (CBI). (3)··Describe any protective equipment and engineering controls usedto protect workers. (4) and (6) •• Inaicate your willingness to havethe informationprovided in column (3) or (5)binding. (5) •• Indicate thephysical formes) ofthe new chemical substance (e.g., solid: crystal, granule, powder, or dust) and % new chemical substance (ifpart ofa mixture) atthe time ofexposure. (7)··Mark (X)this columnifentry in column (5) is confidential business information (CHI). (8) •• Estimatethe maximum number ofworkers involved in each activity for all sites combined. (9) •• Mark (X)this column ifentry in column (8) is confidential business information (CBI). (10) and (II)·· Estimate the maximum duration ofthe activity for any worker in hours per day and days per year. (12)
..Mark'**'~"iN** 10) and (I 1) are confidential business information CBl). Worker activity Protective Equipment! Binding Physical forms(s) Binding eBI #of eBI Maximu eBI m (i.e., bag dumping, filling drums) Engineering Controls Option and % new Option Worker Hrs/day Daysfyr Mark (x) substance Mark (x) S (1) (3) (4) (5) (6) (7) Expose (9) (10) (1) (12) d (8) 

### No exposure is expected in import and transshipment 

# r procedures. Refer to Attachment 5: Risk Evaluation. 

# I:8J Mark (X)this boxifyou attach a continuation sheet. 

### See Attachment 5. 3. Envirolll1lentalRelease and Disposal •• You must make separate confidentiality claims for therelease number and the amount ofthenew chemical substance released and other release and disposal information. Mark (X)the "Confidential"box nextto each item you claim as confidential. (1) .•Enter the number ofeach release point identifiedinthe process description, partII, section A, subsection Id(3). (2)··Estimate the amount ofthe new substancereleased (a) directlyto the environment or(b) into control technology (inkg/day or kg/batch). (3)
..Mark (X) this column ifentries in columns (1) and (2) are confidential business information (CHI). (4) .•Identifythemedia (stack air, fugitive air (optional·see Instruction Manual), surface water, on·site or off·site land or incineration, POTW, orother (specifY))to which the new substance will be released from thatrelease point. (5)
..a. Describe control technology, ifany, and control efficiencythat will be usedto limit the release ofthe new substance tothe environment. Forreleases disposed ofon land, characterizethe disposal method and state whether itis approved for disposal ofRCRAhazardous waste. On a continuation sheet, for each site describe any additional disposal methods that will be used and whetherthe waste is subjectto secondary ortertiary on·sitetreatment. b. Estimate the amount releasedtothe environment after controltechnology (in kg/day). (6) •• Mark (X)this column ifentries in columns (4) and (5) are confidential business information (CBI). (7) •• IdentifY the destination(s) ofreleases to water. Please supply NPDES (National PollutantDischarge Elimination System) numbers for direct discharges or NPDES numbers ofthe POTW (Publici Owned Treatment Works). Mark (X) ifthe POTW name or NPDES # is confidential business information(CBI). Release Amount ofnew substance CHI Media of Controltechnology and efficiency (you may wishto optionally attach efficiency data) CBI Number released release

(I) (2a e.g.naekair Binding (3) (4) (5a) Mark (X) (5b) (6) 

### No release is expected in import procedures, refer to Attachment 5: Risk Evaluation.

(7) Mark (X) the 

# o POTW provide name(s) below: CHI 

# o Navigable 

# o Other· SpecifY provide NPDES # CBI '--­ destination(s) of waterway releases to water. 

### NA NA orno NA releases Mark (X) this box ifyou attach a continuation sheet. 

### See Attachment 5 EPAFORM 7710·25 (Rev. 5·95) Page 9

### Part 11-- HUMAN EXPOSURE AND ENVIRONMENTAL RELEASE -- Continued Section B --INDUSTRIAL SITES 

### CONTROLLED BY OTHERS Complete section B fortypical processing or use operations involvingthe new chemical substance at sites you do not control. Importers do not have to complete this section for operations outsidethe U.S.; however, you mustreportanyprocessing or use activities after import. Seethe Instructions Manual. Complete a separate sectionBfor each type of processing. oruse operation involving the newchemical substance. Ifthe same operation is perfonned at more than one site describe the ty ical 0 eration commontothese sites. Identi additional sites ona continuation sheet. 1. OperationDescription •• To claim information in this section as confidential, circle or bracketthe specific infonnation that you claim as confidential. (l) Diagram the major unitoperation steps and chemical conversions, including interim storage andtransport containers (specifY

- e.g. 5 gallonpails, 55 gallon drums, rail cars,tanktrucks, etc). Onthe diagram, identifY byletter andbriefly describe each worker activity. (2)

-- Providethe identity, the approximate weight (by kg/day orkg/batch, on an 100%new chemical substance basis), and entry point ofall feedstocks (includingreactants, solvents and catalysts, etc) and all products, recycle streams, and wastes. Include cleaning chemicals (note frequency ifnot used daily orper batch). (3)

-- Identify by numberthe points ofreiease, including small orintermittent releases, tothe environment ofthe new chemical substance. (4) Please enter the # ofsites (remembertoidentifythelocations of these sites on a continuation sheet):
# ofsites



# t8J Mark (X) this box ifyou attach a continuation sheet. 

### See a e lOA. 3-5 

### sites (by year 3). 2. WorkerExposurelEnvironmental.Release (I) Fromthe diagram above, providethe letter for eachworker activity. Complete 2-8 for each worker activity described (2)
..Estimate thenumber ofworkers exposed for all sites combined. (4)

-- Estimatethetypical duration ofexposure perworker in(a) hours per day and (b) days per year. (6)

-- Describe physical form ofexposure and % new chemical substance (ifin mixture), and anyprotective equipment and engineering controls, ifany, usedto protectworkers. (7)

-- Estimatethe percentofthe new substance as fonnulated when packaged orused as a fmal product. (9) _. From the process diagram above, enter the number ofeachreleasepoint. Complete 9-13 for eachrelease point identified. (10)

-- Estimatethe amount ofthenew substance released (a) directlytothe environment or(b) into controltechnologytothe environment (inkg/day orkgibatch). (12) .- Describe media ofreleasei.e. stack air, fugitive air (optional-see Instructions Manual), surface water, on-site or off-site land orincineration, POTW, orother (specifY) and control technology, ifany. that will be usedto limitthe release ofthe new substancetothe environment. (14)

-- Identify byproducts which may result from the operation.

(3), (5), (8), 11), (13) and (15)

-­ Mark (X) this column ifany ofthe proceeding entries are confidential business information (CBI). Letter #of CBI Duration CBI Protective Equip. / %in eBI Release Amountof CDI MediaofRelease em

of Workers of Engineering Controls! Form- Number New & Control Act- Exposed Exposure Physical Fonn and % ulation Substance Technology ivity new substance Released (I) (2) (3) (4a) (4b) (5) (6) (1) (8) (9) (lOa) (lOb) (11) (12) (13) X X

X X

X 

# W**~** I (15)



# t8J Mark (X)this boxifyou attach a continuation sheet, 

### seepage lOA EPAFORM 7710-25 (Rev. 5-95) Page 10

## OPTIONAL POLLUTION PREVENTION INFORMATION To claim information

### inthis section as confidential circle orbracketthe specific informationthatyou claim as confidential. 

### In this section you may provide information not reported elsewhere in this form regarding your efforts to reduce orminimize potential risks associated with activities surrounding manufacturing, processing, use and disposal ofthe PMN substance. Please include new information pertinent to pollution prevention, including source reduction, recycling activities and safer processes or products available due to the new chemical substance. Source reduction includes the reduction in the amount ortoxicity ofchemical wastes by technological modification, process and procedure modification, productreformulation, raw materials substitution, andlor inventory control. Recycling refers to the reclamation ofuseful chemical components from wastes that would otherwise be treated orreleased as air emissions or water discharges, orland disposal. Descriptions ofpollution prevention, source reduction and recycling should emphasize potential risk reduction subsequent to compliance with existing regulatory requirements and canbe either quantitative or qualitative. The EPA is interested in the information to assess overall net reductions in toxicity or environmental releases and exposures, not the shifting ofrisks to other environmental media or non-environmental areas (e.g., occupational or consumer exposure). In addition, information on the relative cost or performance characteristics ofthe PMN substance to potential alternatives may be provided. All 

### information provided in this section will be taken into consideration during the review ofthis substance. See Instructions Manual and Pollution Prevention Guidance manual for guidance and examples. Describe the expected netbenefits, such as (I) an overallreduction

### inriskto humanhealth orthe environment; (2) a reduction inthe volume manufactured; (3) a reductioninthe generation ofwaste materials throughrecycling, source reduction or other means; (4) a reduction inpotential toxicity orhumanexposure and/or environmentalrelease; (5) anincrease 

### inproductperformance, a decrease 

### in the cost ofproduction and/or improved operation efficiency ofthe new chemical substance 

### in comparisonto existing chemical substances used in similar application; or (6) the extentto whichthe new chemical substance may be a substitute for anexisting substance thatposes a greater overall risk to humanhealthorthe environment. 

### This substance will be imported into the US, thereby eliminating possible releases associated with manufacturing. However, CYTEC is committed to protection of health and the environment under all statutes and regulations for those products that are manufactured in the US. This includes our commitment to CMA's Responsible Care program (including Pollution Prevention and Product Stewardship Codes).



# D Mark (X) thisboxifyou attach a continuation sheet.

EPA FORM 7710-25 (Rev. 5-95) Page II

## Part III -- LIST OF ATTACHMENTS Attach continuation sheets for sections ofthe form andtestdata and other data (including physicaVchemical properties and structure/activity information), and optional informationafterthis page. Clearly identify the attachment andthe section ofthe form to which it relates, ifappropriate. Numberconsecutivelythe pages ofthe attachments. Inthecolumn below, enter the inclusive page numbers ofeach attachment. Mark(X)the "Confidential"box next to any attachment name you claim as confidential. Read theInstructionsManualfor guidance on how to claim any informationinanattachment as confidential. You mustinclude withthe sanitized copy ofthe notice form a sanitized version ofany attachment inwhich you claiminformation as confidential. Attachmentname 

### Attachment 1: Material Safety Data Sheet (MSDS) Attachment 2: Label Attachment 3: CAS Inventory Expert Service Report Attachment 4: IR Spectrum Attachment 5: Tox Summary Attachment 6: Risk Evaluation Attachment 7: Process Description Attachment 8: MSDS for Reactants Attachment 9: Final Toxicological Testing Reports Attachment page number(s) 

### 14-21 22-23 24-27

28 29-33 34-35

36 37-55 56-205 Confidential



### X X

X X X

I I I

I
I



# D Mark (X)this boxifyou attach a continuation sheet. Enterthe attachmentname and number.

EPA FORM7710-25 (Rev. 5-95) Page 12

### PHYSICAL AND CHEMICAL PROPERTIES WORKSHEET To assist EPA'sreview ofphysical and chemicalproperties data, please complete the following worksheet for data you provide and include it inthenotice. Identifythe propertymeasured, the page ofthe notice on which the property appears, the value ofthe property, theunits in whichthe property is measured (as necessary), and whether or not the propertyis claimed as confidential. The physical state ofthe neat substance should be provided. These measured properties should be for the neat (100%pure) chemical substance. Propertiesthat are measured for mixtures or formulations should be so noted (% PMN substance in

### -.l. You are notrequired to submitthis worksheet; however, EPA strongly recommendsthatyou do so, as it will simplifyreview and ensurethat confidential -information is properlyprotected. You should submit this worksheet as a supplementto your submission oftest data. 'This worksheet is not a substitute for submission oftest data. Property Page Value [Measured 0 Conndential (a) Physical state ofneat substance Vapor pressure @ Temperature °C Density/relative density @25°C Solubility 

### @ Temperature °C

Solvent Solubility in water 

### @ Temperature °C Meltingtemperature Boiling/ sublimationtemperature@ torrpressure Spectra 

### IR., NMR Dissociation constant Particle size distribution Octanollwaterpartition coefficient Henry's Law constant IVolitalizationfrom water 

# IVolitalizationfrom soil rPh @ concentration 10%indeionized water Flammability (Flashpoint) Explodability Adsorption 

### I coefficient Other

- Specify number (c) (s) X (1) (g)
Torr X 0.991 glcm3 X Ivery soluble in most polar solvents e.g. acetone, alcohols acetonitrile etc. gIL X insoluble gIL °C °C

X 3.45 X 105 

### OF Estimate Mark (X) (M or E) (d)

M



# =

M M

ATTACHMENT PAGE 13

# IYTEI: h,tclmology 

## ahaQ,/of 

## its limam 

### MSDS: 0014173 Date: 02/04/2003 

## MATERIAL SAFETY DATA SHEET 

# 1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATION Product Name: 

### AERO® 5715 Promoter Synonyms: None Chemical Family: Modified Thionocarbamate Molecular Formula: Mixture MolecularWeight: Mixture CYTEC INDUSTRIES INC

.. FIVE GARRET MOUNTAIN PLAZA, WEST PATERSON. NEW JERSEY 07424, USA For Product Information call 1-800/652-6013. Outside the USA and Canada call 1-973/357-3193. EMERGENCY PHONE: For emergency involving spill. leak. fire. exposure or accident call CHEMTREC: '!-8001424­ 

### 9300. Outside the USA and Canada call 1-703/527-3887. 

### ® indicates trademark registered in the U.S. Outside the U.S., mark may be registered. pending or a trademark. Mark is or may be used under license. 

# ---------------_._-----­ 2. COMPOSITION/INFORMATION ON INGREDIENTS OSHA REGULATED COMPONENTS Component 

### I CAS No. Isobutanol 78-83-1 

### % 15 - 20 

### (w/w) OSHA (PEL): 100 ppm ACGIH (TLV) 50 ppm Carcinogen

Quinoline 91-22-5 1 - 2' Not Established Not Established
Modified thionocarbamate Proprietary No! Established Not Established



# 3. HAZARDS IDENTIFICATION EMERGENCY OVERVIEW APPEARANCE AND ODOR: Color: Appearance: Odor: brown to amber clear liquid alcohol/aromatic STATEMENTS OF HAZARD:AERO® 5715 Promoter MSDS: 0014173 Date: 02104/2003 Page 2 of8
WARNING! COMBUSTIBLE LIQUID AND VAPOR MAY CAUSE ALLERGIC SKIN REACTION MAY CAUSE EYE IRRITATION CHRONIC HAZARD WARNING: CONTAINS MATERIAL WHICH CAUSED GENETIC CHANGES IN LABORATORY ANIMAL TESTS Risk of effects depends on duration and level ofexposure 

### POTENTIAL HEALTH EFFECTS EFFECTS OF OVEREXPOSURE: The acute oral (rat) LD50 value is estimated to be greater than 500 mg/kg and less than 1,000 mg/kg. The dermal (rabbit) LDSO value is greater than 2.000 mg/kg. Direct contact with this material may cause mild eye and minimal skin irritation. Repeated or prolonged dermal contact may cause allergic skin reactions. Overexposure to vapors may cause irritation of the respiratory tract and eyes and may cause central nervous system effects. Refer to Section 11 for toxicology information on the regulated components of this product. 

## 4. FIRST AID MEASURES Ingestion: Ifswallowed, call a physician immediately. Only induce vomiting at the instruction of a physician. Never give anything by mouth to an unconscious person. 

### Skin Cm,tact: Wash immediately with plenty ofwater and soap. Remove contaminated clothing and shoes'without delay. Obtain medical attention. Do net reuse contaminated clothing without laundering. Destroy or thoroughly clean shoes before reuse. 

### Eye Contact: Rinse immediately with plenty ofwater for at least 15 minutes. 

### Inhalation: Remove to fresh air. If breathing is difficult, give oxygen. Obtain medical advice if there are persistant symptoms.


# 5. FIRE-FIGHTING MEASURES Extinguishing Media: Use water spray. alcohol foam, carbon dioxide or dry chemical to extinguish fires. Water stream may be ineffective. 

### Protective Equipment: Firefighters, and others exposed, wear self-contained breathing apparatus. Wear full firefighting protective clothing. See Section 8 (Exposure Controls/Personal Protection). Use approved air-:;upplied full face respirator. 

### Special Hazards: Keep containers cool by spraying with water ifexposed to fire.


## 6. ACCIDENTAL RELEASE MEASURES Personal Precautions: Where exposure level is known, wear approved respirator suitable for level of exposure. Where exposure level is not known, wear approved, positive pressure, self-contained respirator. In addition to the protective clothing/equipment in Section 8 (Exposure Controls/Personal Protection), wear impermeable boots.AERO® 5715 Promoter MSDS: 0014173 Date: 02104/2003 Page 3 of8
Methods For Cleaning Up: Cover spills with some inert absorbent material; sweep up and place in a waste disposal container. Flush spill area with wate·r. Remove sources of ignition. Environmental Precautions: Use appropriate containment to avoid environmental contamination.


# 7. HANDLING AND STORAGE HANDLING Precautionary Measures: Keep away from heat and flame. Avoid prolonged or repeated contact with skin. Avoid contact with eyes. Wash thoroughly after handling. Handling Statements: None STORAGE Areas containing this material should have fire safe practices and electrical equipment in accordance with applicable regualtions and/or guidelines. Standards are primarily based on the material's flashpoint, but may also take into account properties such as miscibility with water ortoxicity. All local and national regulations should be followed. In the Americas, National Fire Protection Association (NFPA) 30: Flammable and Combustible Liquids Code, is a widely used standard. NFPA 30 establishes storage conditions for the following classes of materials: Class I Flammable Liquids, Flashpoint <37.SC Class II Combustible Liquids, 37.SC < Flashpoint <60C Class Ilia Combustible Liquids, 60 C < Flashpoint < 93C Class Illb Combustible Liquids, Flashpoint > 93 C StorageTemperature: Room temperature Reason: Integrity 

# 8. EXPOSURE CONTROLS/PERSONAL PROTECTION Engineering Measures: Where this material is not used in a closed system, good enclosure and local exhaust ventilation should be provided to control exposure. Respiratory Protection: Where exposures are below the established exposure limit. no respiratory protection is required. Where exposures exceed the established exposure limit. use respiratory protection recommended for the material and level of exposure. Eye Protection: Wear eye/face protection such as chemical splash proof goggles or face shield. Eyewash equipment and safety shower should be provided in areas of potential exposure. Skin Protection: Avoid skin contact. Wear impermeable gloves and suitable protective clothing. Additional Advice: Food, beverages, and tobacco products should not be carried, stored, or consumed where this material is in use. Before eating, drinking. or smoking. wash face and hands thoroughly with soap and water. It is recommended that a shower be taken after completion ofworkshift especially ifsignificant contact has occurred. Work clothing should then be laundered prior to reuse. Street clothing should be stored separately from work clothing and protective equipment Work clothing and shoes should not be taken home. 

# 9. PHYSICAL AND CHEMICAL PROPERTIES Color: brown to amber Appearance: clear liquidAERO® 5715 Promoter MSDS: 0014173 Date: 02104/2003 Page 4 of 8
Odor: Boiling Point: Melting Point: Vapor Pressure: Specific Gravity: Vapor Density: Percent Volatile (By Wt.): pH: Saturation In Air 

### (% ByVo!.): Evaporation Rate: Solubility In Water: Volatile Organic Content: Flash Point: Flammable Limits (% ByVol): Autoignition Temperature: Decomposition Temperature: Partition coefficient (n­ octanollwater): Odor-rhreshold: alcohol/aromatic Not available Not available Not available 0.991 Not available Not available 3.45 Not available (value for isobutanol) Dispersible Not available 40.6 °C 105 OF Pensky-Martens Closed Cup Not available Not available Not available Not available See Section 2 for exposure limits. 

# 10. STABILITY AND REACTIVITY Stability: Conditions To Avoid: Polymerization: Materials To Avoid: Hazardous Decomposition Products: Stable Avoid contact with oxidizing agents, bases or amines. Will not occur Alkali or amines, oxidizing agents. carbon dioxide carbon monoxide oxides of nitrogen oxides ofsulfur (includes sulfur di and tri oxides) 

# 11. TOXICOLOGICAL INFORMATION Toxicological information for the product is found under Section 3. HAZARDS IDENTIFICATION. Toxicological information on the regulated components ofthis product is as follows: Modified thionocarbamate toxicological properties have not been fully investigated. This material was negative in the Ames Salmonella Assay and was negative for Chromosome Aberrations, however, it was positive in the Mouse Micronucleus Assay. Based on a structurally similar material, the estimated acute oral (rat) LD50 and acute dermal (rabbit) LD50 values are >1.700 mg/kg and >2.000 mg/kg, respectively. Direct contact with this material may cause mild eye and moderate skin. Repeated or prolonged dermal contact with modified thionocarbamate may cause allergic skin reactions. Isobutanol has acute oral (rat) and dermal (rabbit) LD50 values of2.46 g/kg and 3.4 g/kg, respectively. The LC50 (rat) following a 4-hour inhalation exposure is >8000 ppm (24.24 mg/L). Acute overexposure to isobutanol vapor can cause irritation to the eyes (severe), skin (moderate). and mucous membranes, as well as, central nervous system depression. Direct contact with isobutanol may cause severe eye and mild to moderate skin irritation.AERO® 5715 Promoter MSDS: 0014173 Dale: 02104/2003 Page 5 of 8
Quinoline (CAS# 91-22-5) has acute oral (rat) and dermal (rabbit) LD50 values of 331 mg/kg and 591 

### mg/kg. Direct c9ntact**~ith** this material may cause moderate-severe eye irritation and moderate skin irritation. The vapor can irritate the eyes, nose, throat and respiratory tract. NTP reports that this material has produced both positive and negative results in chromosome aberration assays, was negative in the mouse lymphoma assay, and positive in the salmonella (Ames) assay for mutagenicity. This material was a liver tumorigen in sub-chronic mouse and rat studies. Quinoline has been reported to be toxic to the retina or optic nerve, affecting vision. California Proposition 65 Warning (applicable in California only)
- This product contains (a) chemical(s) known to the State of California to cause cancer. 

# 12. ECOLOGICAL INFORMATION Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. This material is not readily biodegradable. ALGAE TEST RESULTS Test: Growth Inhibition (OECD 201) Duration: 72 hr Species: Green Algae (Selenastrum capricornutum) >1 - 10 mg/l EbC50 Information based on a structurally similar material. >10 - 100 mg/l ErCSO Information based on a structurally similar material.
FISH TEST RESULTS Test: Acute toxicity. freshwater (OECD 203) Duration: 96 hr. Species: Rainbow Trout (Oncorhyncus mykiss) 

### 7.1 mg/l LCSO

INVERTEBRATETEST RESULTS Test: Acute Immobilization (OECD 202) Duration: 48 hr Species: Water Flea (Daphnia magna) 

### 7.7 mg/l ECSO

DEGRADATION Test: C02 Evolution: Modified Sturm (OECD 301 B) Duration: 28 day Procedure: Ready biodegradability 17.S %AERO® 5715 Promoter MSDS: 0014173 Date: 02104/2003 Page 6 of 8 

## 13. DISPOSAL CONSIDERATIONS The information on RCRA waste classification and disposal methodology provided below applies only to the Cytec product, as supplied. If the material has been altered or contaminated, or it has exceeded its recommended shelf life, the guidance may be inapplicable. Hazardous waste classification under federal regulations (40 CFR Part 261 et seq) is dependent upon whether a material is a RCRA 'listed hazardous waste'or has any of the four RCRA 'hazardous waste characteristics.' Refer to 40 CFR Part 261.33 to determine if a given material to be disposed of is a RCRA 'listed hazardous waste'; information contained in Section 15 ofthis MSDS is not intended to indicate if the product is a 'listed hazardous waste:RCRA Hazardous Waste Characteristics: There are four characteristics defined in 40 CFR Section 261.21-61.24: Ignitability, Corrosivity, Reactivity, and Toxicity. To determine Ignitability, see Section 9 of this MSDS {flash point}. For Corrosivity, see Sections 9 and 14 (pH and DOT corrosivity). For Reactivity, see Section 10 (incompatible materials). For Toxicity, see Section 2 (composition). Federal regulations are subject to change. State and local requirements, which may differ from or be more stringent than the federal regulations, may also apply to the classification ofthe material if it is to be disposed. Cytec encourages the recycle, recovery and reuse of materials, where permitted, as an alternate to disposal as a waste. Cytec recommends that organic materials classified as RCRA hazardous wastes be disposed of by thermal treatment or incineration at EPA approved facilities. Cytec has provided the foregoing for information only; the person generating the waste is responsible for determining the waste classification and disposal method. 

## 14. TRANSPORT INFORMATION This section provides basic shipping classification information. Refer to appropriate transportation regulations for specific requirements. US DOT Proper Shipping Name: Flammable liquid, n.o.s. Hazard Class: 3 Packing Group: III UNIID Number: UN1993 Transport Label Required: Flammable Liquid Marine Pollutant Technical Name (N.O.S.): Contains isobutanol and modified thionocarbamate Hazardous Substances: Component / CAS No. Reportable Quantity of Product (lbs) Isobutanol 25000
TRANSPORT CANADA Proper Shipping Name: Flammable liquid, n.o.s. Hazard Class: 3 Packing Group: III UN Number: 1993 Transport Label Required: Flammable Liquid Marine Pollutant Technical Name {N.O.S.}: Contains isobutanol and modified thionocarbamate ICAOIIATA Proper Shipping Name: Flammable liquid, n.o.s. Hazard Class: 3 Packing Group: III UN Number: 1993 Transport Label Required: Flammable Liquid Marine Pollutant Packing Instructions/Maximum Net Quantity Per Package: Passenger Aircraft: 309; 60 L Cargo Ajrcraft: 310; 220 LAERO® 5715 Promoter MSDS: 0014173 Date: 02104/2003 Page 7 of 8
Technical Name (N.O.S.): Contains isobutanol and modified thionocarbamate
IMO Proper Shipping Name: Flammable liquid, n.o.s. Hazard Class: 3 UN Number: 1993 Packing Group: III Transport Label Required: Flammable Liquid Marine Pollutant Technical Name (N.O.S.): Contains isobutanol and modified thionocarbamate 

# 15. REGULATORY INFORMATION INVENTORY INFORMATION United States (USA): The chemical, physical, and toxicological properties of this material have not been fully investigated. Its handling or use may be hazardous. Exercise Due Care. Since this material may contain chemicals not included in the Toxic Substances Control Act Inventory, it must be used under the supervision of technically qualified individuals. Materials not included in the Toxic Substance Control Act Inventory must not be used for commercial purposes. Canada: This product contains components not on the Domestic Substances List. European Union (EU): Product is not included in the European Inventory of Existing Chemical Substances (EINECS). Product can be supplied in quantities less than 10 kg/year according to Council Directive 67/548/EEC and its amendments. OTHER ENVIRONMENTAL INFORMATION The following components of this product may be subject to reporting requirements pursuant to Section 313 of CERCLA (40 CFR 372), Section 12(b) ofTSCA, or may be subject to release reporting requirements (40 CFR 307, 40 CFR 311, etc.) See Section 13 for information on waste classification and waste disposal of this product. Component 

### I CAS No. TPQ(lbs) RQ(lbs) S313 TSCA12B Isobutanol NONE 5000 No No 78-83-1 Quinoline NONE 5000 Yes No 91-22-5
PRODUCT HAZARD CLASSIFICATION UNDER SECTION 311 OF SARA • Acute • Chronic • Fire 

# 16. OTHER INFORMATION NFPA Hazard Rating (National Fire Protection Association) Health: 2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury. Fire: 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Reactivity: 0 - Materials that in themselves are normally stable, even under fire exposure conditions.AERO® 5715 Promoter MSDS: 0014173 Date: 02104/2003 Page 8 of 8
Reasons For Issue: 

### New Product
Randy Deskin, Ph.D., DABT +1-973-357-3100 This information is given without any warranty or representation. We do not assume any legal responsibility for same, nor do we give permission, inducement, or recommendation to practice any patented invention without a license. It is offered solely for your consideration, investigation, and verification. Before using any product, read its label.US Label Prototype # LUS 0014173 02104/2003 AERO® 5715 Promoter Page 1 of2 

# rYTEI: 1;'dmology ahead ofits limam 

# AERO® 5715 Promoter Sulfide mineral collector 

### Precautionary Warning Statement: WARNING! COMBUSTIBLE LIQUID AND VAPOR MAY CAUSE ALLERGIC SKIN REACTION MAY CAUSE EYE IRRITATION



### ONTAtNSMATERIALWHICH CAUSED GENETIC CHANGES IN LABORATORYANIMAL TESTS isk ofeffects de ends on duration and level ofex osure Keep away from heat and flame. Avoid prolonged or repeated contact with skin. Avoid contact with eyes. Wash thoroughly after handling. 

### FIRST AID Eye Contact: Rinse immediately with plenty ofwater for at least 15 minutes. 

### Skin Contact: Wash immediately with plenty ofwater and soap. Remove contaminated clothing and shoes without delay. Obtain medical attention. Do not reuse contaminated clothing without laundering. Destroy or thoroughly clean shoes before reuse. 

### Inhalation: Remove to fresh air. If breathing is difficult. give oxygen. Obtain medical advice if there are persistant symptoms. 

### Ingestion: If swallowed. call a physician immediately. Only induce vomiting at the instruction of a physician. Never give anything by mouth to an unconscious person. Notice: FOR RESEARCH AND DEVELOPMENT PURPOSES ONLY The chemical. physical and toxicological properties ofthis material have not been fully investigated. Its handling or use may be hazardous. Exercise due care. Since this material may contain chemicals not included in the Toxic Substances Control Act Inventory. it must be used under the supervision oftechnically qualified individuals. Materials not included in the Toxic Substances Control Act Inventory must not be used for commercial purposes. 

### ® indicates trademark registered in the U.S. Outside the U.S.• mark may be registered, pending or a trademark. Mark is or may be used under license. 

### Right-to-know data for Component 

### I CAS No. Before handling this material, read Cytec Material Safety Data Sheet

### # 0014173 for more detailed safety, health and environmental data. The following components of this product are listed in accordance with right-to-know laws: 

### Component 

### I CAS No. Isobutanol 78-83-1 Quinoline 91-22-5US Label Prototype # LUS 0014173 02/04/2003 AERO® 5715 Promoter Page 2 of 2
Modified thionocarbamate

Standard Packaging Statements: Drums: ATTENTION
- Container headspace may contain hazardous gas or vapor. Open container with care, using adequate ventilation and avoiding ignition sources. Do not use air pressure or apply heat with open flame to remove contents of container. After emptied, container may retain solid, liquid, and/or vapor residues. Continue to observe all precautions, if any, on label. Do not cut, puncture, torch, or weld on or near emptied container. Do not use for other purposes. Bags: ATTENTION
- After emptying, bag may retain solid, liquid, and/or vapor residues. Continue to observe all precautions, if any, on label. Do not cut, puncture, torch, or weld on or near emptied container. Do not use for other purposes. Tank car/truck (bulk): ATTENTION
- Container headspace may contain hazardous gas or vapor. Open container with care, using adequate ventilation and avoiding ignition sources. DO NOT REMOVE TAG UNTIL TANK IS CLEANED.

CYTEC INDUSTRIES INC.
- WEST PATERSON, NJ 07424 USA Emergency Phone
- In Canada: 905/356-8310; In USA: 1-800/424-9300 or 703/527-3887

## TOXICOLOGY SUMMARY Toxicology test results include data for the P:MN substance (98+%) as well as data for a final fonnulated product, which contains the P:MN substance at (-70%). It 

### should be noted that the P:MN substance will be supplied to customers in product fonnulations only, and not as a "pure" chemical. Test Material- PMN Substance (98+%) Ames Test

- Salmonella typhimurium 

### strains TA1535, TA1537, TA98, TAlOO and E. 

### coli strain WP2uvrA- were treated with solutions ofthe test material using the Ames plate incorporation method at up to seven dose levels, in triplicate, both with and without the addition of a rat liver homogenate metabolizing system. No significant increases in the frequency ofrevertant colonies were recorded for any of the bacterial strains, with any dose ofthe test material, either with or without metabolic activation. Based on these results, the test material was considered to be non-mutagenic. 

### In Vitro ChromosomeAberrations Test in Human Lymphocytes

- Duplicate cultures ofhuman lymphocytes. treated with the test material, were evaluated for chromosome aberrations at up to three dose levels, together with vehicle and positive controls. Four treatment conditions were used in this study, i.e. in Experiment 1,4 hours in the presence of an induced rat liverhomogenate metabolizing system (S9), at a 1 % final concentration with cell harvest after a 20-hour expression period and a 4-hourexposure in the absence ofmetabolic activation (S9) with a 20-hour expression period. In Experiment 2, the 4­ hourexposure with addition ofS9 was repeated (using a 2% final S9 concentration), while in the absence ofmetabolic activation the exposure time was increased to 24 hours. All vehicle (solvent) controls gave frequencies ofcells with aberrations within the range expected for nonnal human lymphocytes. All positive control treatments gave statistically significant increases in the frequency of cells with aberrations indicating the satisfactory perfonnance ofthe test and the activity ofthe metabo1izing system. The test material did not induce any statistically significant increases in the frequency of cells with aberrations, in either ofthe two separate experiments, using a dose range that included a dose level that induced approximately 50% mitotic inhibition. Based on these results, the test material was shown to be non-clastogenic to human lymphocytes. Initial

### In Vivo Mouse Micronucleus Test - A range-finding study was perfonned to find suitable does levels ofthe test material and to investigate to see ifthere was a marked difference in toxic responses between the sexes. There was no marked difference

### in test material toxicity between the sexes; therefore the main study was performed using only male mice. The micronucleus study was conducted using the oral route in groups of seven mice (males) at the maximum tolerated dose (MTD) 200 mglkg with 100 and 50 mg/kg as the two lower dose levels. Animals were sacrificed 24 or48 hours later, the bone marrow extracted and smear preparations made and stained. Polychromatic (PCE) and normochromatic (NCE) erythrocytes were scored for the presence ofmicronuclei. Further groups ofmice were given a single oral dose ofarachis oil (7 mice) or dosed orally with cyclophosphamide (5 mice), to serve as vehicle andpositive controls, respectively. Vehicle control animals were sacrificed 24 or48 hours later, and positive control animals were sacrificed after 24 hours. A statistically significant decrease in the PCElNCE ratio was observed in the 48-hour test material dose group when compared to the concurrent control group, indicating a cytotoxic response in the bone marrow. This was accompanied by the observation of premature deaths and clinical signs and was taken to indicate that systemic absorption and exposure to the target tissue had occurred. Increases in the incidence ofmicronucleated polychromatic erythrocytes (MNPCE) were observed in animals dosed with the test material when compared to the concurrent vehicle controls groups. However, the increases in the incidence ofMNPCEs in both the 24 and 48-hour 200 mg/kg test material groups were not statistically significant. In both cases the increase was greater than two-fold overthe concurrentcontrol and some individual animals had frequencies ofMNPCEs that were far in excess ofthe historical maxima. The positive control material produced a marked increase in the frequency of micronucleated polychromatic erythrocytes. Based on these results, the test material was considered to be weakly genotoxic at a dose level thatwas close to the toxic 

### limit. Second

### In Vivo Mouse Micronucleus Assay

- Due to the equivocal positive result seen only at the high dose (200 mg/kg) in the original study, we conducted a second assay at a second independent laboratory, using the same dose levels, male mice, but with a different strain ofmouse. Seven mice/dose group were sacrificed approximately 24 hr (control and test article treatment groups), and 48 hr (control and 200 mglkg groups only) after treatment, and bone marrow was evaluated for cytotoxicity and micronucleus formation. A vehicle control group and a urethane positive control group (this group contained 5 mice only and was sacrificed at 24 hr) were treated similarly and evaluated concurrently with the treated test material groups. There was no significant suppression ofPCE among red bloodcells at any dose level, which indicates the absence ofbone marrow cytotoxicity_ There was a statistically

### significant increase in the frequency ofmicronucleated peE 

### at all dose levels at both the 24 and 48 hr time points. 

## Based on these data,the test material was considered to be genotoxic. Test Material- Formulated Product AERO® 5715 Promoter (CT-752-02 & 

## CT765-02) TEST MATERIAL COMPOSITION: PMN Substance -70% Isobutanol -20% Isobutyl carbamate -5% Diisobutyl carbonate -4.5% Quinoline -1% Acute OralToxicity (In Progress)

- Results to date: 5/5 male rats dead at 5000 mglkg; 4/5 male rats at 2000 mg/kg; 3/5 male rats dead at 1000 mg/kg. Dosing of additional five male rats at 500 mg/kg set for the week of2110/03. 

## Acute Dermal Toxicity (Complete

- waiting for final report)

- A group offive healthy male New Zealand White rabbits were dosed dermally at 2000 mglkg ofbody weight. The test article was kept in contact with the skin for 24 hours. Dermal responses were recorded at 24 hours postdose and again on day 7. Animals were observed at 1, 4 and 24 hours postdose for mortality, toxicity and clinical signs and once daily thereafter for seven days for mortality only. Fouroffive animals survived the 2000 mg/kg dermal application. One animal died on day 4. Instances offew feces were noted at the 24-hour observation in two animals. Body weight changes were normal in % 

### survivors. One animal lost weight. Dermal responses were absent to well defined at 24 hours and absent on day 7. 

## Based on these results, the acute dermal (rabbit) LD50 is greaterthan 2000 mg/kg. PrimaryDermaVOcular Irritation (Complete

- waiting for final report)

- The test material was applied to one intact site (0.5 ml/site) on the clipped back ofeach ofthree New Zealand White rabbits for an exposure period of4 hours. During the 4 hour occluded exposure the test sites were examined at 3 minutes and gain at 1hour postdose. At4 hours the wrappings were removed and the skin reactions were scored at 24, 48 and 72 hours after patch removal. There was no erythema or edema noted at any observation period. The modified Primary Dermal Irritation Index is 

### O. 

## Based on these data, the test material was non-irritating to rabbit skin.

### The same three rabbits used in the dermal portion ofthe study were also used to assess the oculareffects ofthe test materiaL In this study, a single application ofthe test material (0.1 ml) to the eyes ofthree New Zealand Albino rabbits produced conjunctival irritation in 3/3 unwashed and 3/3 washed eyes, which cleared in all eyes by 72 hours. There was no iritis or corneal opacity noted at any observation period. There were no abnormal clinical signs noted during the observation period. Based on these data, the test material is considered to be a minimal-mild eye irritant in rabbits. Guinea Pig Sensitization (Buehler)

- In progress 

### In Vivo MouseMicronucleus Assay

- Based on the results of a dose rangefinding assay, the maximum tolerated dose was estimated to be 1500 mg/kg. In the definitive assay, the test material was mixed with 21.02% isobutanol in cell culture grade water. The doses were administered via oral gavage to six males per dose level at each scheduled harvest timepoint. The dose levels were 375, 750 or 1500 mglkg. Five animals were dosed with the test material at 375 or 750 mglkg and five animals dosed with the positive control article were euthanized -24 hours after dosing for extraction of the bone marrow. Five animals perharvest timepoint dosed with the test material at 1500 mg/kg and five animals perharvest timepoint dosed with the vehicle control were euthanized 24 or48 hours after dosing for extraction ofthe bone marrow. At least 2000 PCEs per animal were analyzed for the frequency ofmicronuclei. Cytotoxicity was assessed by scoring the number ofPCEs and normochromatic erythrocytes (NCEs) in at least the first 500 erythrocytes for each animal. The vehicle control article, 21.02% isobutanol in cell culture grade water, induced signs of slight hypoactivity and/or ataxia in all ofthe animals immediately postdose; all animals were normal by 1 hour postdose. The test material, induced slight hypoactivity and ataxia, as well as irregular respiration, squinted eyes, recumbency, and labored respiration. Six ofthe eighteen animals dosed at 1500 mglkg were found dead 2 days after dose administration. The test material induced a statistically significant increase in micronucleated PCEs at the high dose at the 48-hourharvest period. In addition, the test material was cytotoxic to the bone marrow (I.e., a statistically significant decrease in the PCE:NCE ratios) at the 48­ hour harvest timepoint. Based on these results, the test material was considered to be genotoxic at a dose level that was close to the toxic limit. Ecological Endpoints: Final Reports To Be Supplied To EPA Upon Receipt Acute Toxicity To

### Daphnia magna - 48-hour EC50 is 7.7 mgIL; NOEC 4.0 mgIL

## Acute Toxicity To Rainbow Trout

- 96-hour LC50 is 

## 7.1 mgIL; NOEC 4.0 mgIL Acute Toxicity To Green Algae

- 

## In Progress 28-Day Biodegradation (Modified SturmTest) 

## -17.5% degradation

### RISK ASSESSMENT Introduction: Riskevaluation is based on hazard and exposure assessments. Hazard refers to the toxicity ofthe material and exposure refers to contact with the material. Human and environmental exposure to the PMN substance is predicted to be low. The PMN substance is manufactured outside ofthe United States. Only formulated products containing 15-50% PMN substance will be imported into the US. As such. data on the product as it is intended for use is more appropriate for assessing potential toxicity and risk to human health and the environment. 

### Health Effects: Mutagenicity tests with the PMN Substance (Purity of98+%) provided the following results: Ames SalmonellalE.Coli 

### Assay Not mutagenic; In vitro 

### Chromosomal Aberrations Assay in Human Lymphocytes

- Not Clastogenic; In vivo 

### Mouse Micronucleus Assay

- Genotoxic Specific toxicological properties ofa formulated product, containing -70% PMN substance, are as follows: acute oral (rat) LD50 is expected to be >500<1000 mglkg (in-progress)

- this would result in a "harmful" classification; acute dermal (rabbit) LD50 >2000 mglkg

- Not classified; non-irritating to rabbit skin; minimal-mildly irritating to rabbit eyes; dermal sensitization (Buehler method)

- in progress; in vivo 

### Mouse Micronucleus Assay considered genotoxic at a dose level that was close to the toxic limit. 

### Environmental Effects: Specific environmental results, to date, indicate that for fish and Daphnids the PMN substance would be classified as " moderately toxic" by standard acute toxicity rating scales. Test results include an acute 96-hour LC50 to rainbow trout of7.1 mg/L, and an acute 48-hour EC50 to Daphnia magna 

### of7.7 mg/L. Acute toxicity testing in green algae is currently in progress. Assessment ofbiodegradability (Modified Sturm) indicated partial degradation, at 17.5%; however, the overall product assessment is not readily biodegradable. 

### Exposure: The PMN substance will 

### be manufactured outside ofthe US in ourAtequiza, Mexico plant; therefore, eliminating this exposure/release scenario. However, the PMN substance will 

### be manufactured using a closed system, where possible. This will be supplemented by the use of personal protective equipment, such as gloves and eye protection. Formulated products containing 15-70%, PMN substance will be imported to either a warehouse or directly to the customer mine site, no handling or processing ofthe PMN substance will occurduring this activity. At the customer mine site the formulated product containing the PMN substance will 

### be metered in by pump orgravity fed to the floatation cell in the closed-loop water recirculation circuit. Usage ofthe formulated product is in the range of

- 10-50 glton ofore, with the ore comprising about 30% ofthe slurry. Therefore, the circuit concentration ofthe PMN substance is approximately 10-50ppm.

### The continuous and recycling nature ofmodern mineral processing operations minimize worker exposure and environmental release at customer sites. 

### In flotation operations, human exposure is 'greatly minimized by use ofautomated continuous operation, minimal staffing and consistent industrial hygiene practices common to the industry. It is predicted that these products will be used at -3-5 mining sites overthe next 3 years. The typical floatation operation would average about 6-12 operators (total for all shifts). Typically, impervious gloves, protective clothing and ventilation are employed as standard industrial hygiene measures. Continuous recycling operations, low concentrations ofPMN substance and high selectivity for metal-bearing sulfide particles also result in minimal environmental release. Destruction orthe entrained PMN substance occurs in the ensuing smelting operations. Smelting occurs at high temperatures (900-1000C) and has a long residence time (0.5-1.0 hrs). This will destroy any remaining PMN substance by oxidation. Risk Evaluation: Although the PMN substance was shown to be genotoxic in the Mouse Micronucleus Assay, we believe that the PMN substance poses a minimal risk to human health and the environment. This conclusion is based on the fact that the potential hazards can be mitigated by the use of appropriate personnel protection equipment, and due to nature ofthe mineral processing operation including tremendous dilution, potential for human orenvironmental exposure is low.