## Chemical

- specific Inputs for EPA’s 2015 Final Updated Human Health Ambient Water Quality Criteria

1 Chemical Name CAS Cancer Slope

Factor, CSF

(per mg/kg

- d) Reference

Dose, RfD

(mg/kg

- d) Relative Source

Contribution, RSC

(

- ) Bioaccumulation Factor

Bioconcen

tration Factor

(L/kg tissue) Trophic Level 2

(L/kg tissue) Trophic Level 3

(L/kg tissue) Trophic Level 4

(L/kg tissue)

1,1,1

- Trichloroethane 71

- 55

- 6 ND 2 0.20 6.9 9.0 10

1,1,2,2

- Tetrachloroethane 79

- 34

- 5 0.2 0.02 0.20 5.7 7.4 8.4

1,1,2

- Trichloroethane 79

- 00

- 5 0.057 0.004 0.20 6.0 7.8 8.9

1,1

- Dichloroethylene 75

- 35

- 4 ND 0.05 0.20 2.0 2.4 2.6

1,2,4,5

- Tetrachlorobenzene 95

- 94

- 3 ND 0.0003 0.20 17,000 2,900 1,500

1,2,4

- Trichlorobenzene 120

- 82

- 1 0.029 0.01 0.20 2,800 1,500 430

1,2

- Dichlorobenzene 95

- 50

- 1 ND 0.3 0.20 52 71 82

1,2

- Dichloroethane 107

- 06

- 2 0.0033 0.078 0.20 1.6 1.8 1.9

1,2

- Dichloropropane 78

- 87

- 5 0.036 0.0893 0.20 2.9 3.5 3.9

1,2

- Diphenylhydrazine 122

- 66

- 7 0.8 ND ND 18 24 27

1,3

- Dichlorobenzene 541

- 73

- 1 ND 0.002 0.20 31 120 190

1,3

- Dichloropropene 542

- 75

- 6 0.122 0.025 0.20 2.3 2.7 3.0

1,4

- Dichlorobenzene 106

- 46

- 7 ND 0.07 0.20 28 66 84

2,4,5

- Trichlorophenol 95

- 95

- 4 ND 0.1 0.20 100 140 160

2,4,6

- Trichlorophenol 88

- 06

- 2 0.011 0.001 0.20 94 130 150

2,4

- Dichlorophenol 120

- 83

- 2 ND 0.003 0.20 31 42 48

2,4

- Dimethylphenol 105

- 67

- 9 ND 0.02 0.20 4.8 6.2 7.0

2,4

- Dinitrophenol 51

- 28

- 5 ND 0.002 0.20 4.4* 4.4* 4.4*

2,4

- Dinitrotoluene 121

- 14

- 2 0.667 0.002 0.20 2.8 3.5 3.9

2

- Chloronaphthalene 91

- 58

- 7 ND 0.08 0.80 150 210 240

2

- Chlorophenol 95

- 57

- 8 ND 0.005 0.20 3.8 4.8 5.4

2

- Methyl

- 4,6

- Dinitrophenol 534

- 52

- 1 ND 0.0003 0.20 6.8 8.9 10

3,3'

- Dichlorobenzidine 91

- 94

- 1 0.45 ND ND 44 60 69

3

- Methyl

- 4

- Chlorophenol 59

- 50

- 7 ND 0.1 0.20 25 34 39

Acenaphthene 83

- 32

- 9 ND 0.06 0.20 510* 510* 510*

Acrolein 107

- 02

- 8 ND 0.0005 0.20 1.0 1.0 1.0

Acrylonitrile 107

- 13

- 1 0.54 ND ND 1.0 1.0 1.0

## Chemical

- specific Inputs for EPA’s 2015 Final Updated Human Health Ambient Water Quality Criteria

2 Chemical Name CAS Cancer Slope

Factor, CSF

(per mg/kg

- d) Reference

Dose, RfD

(mg/kg

- d) Relative Source

Contribution, RSC

(

- ) Bioaccumulation Factor

Bioconcen

tration Factor

(L/kg tissue) Trophic Level 2

(L/kg tissue) Trophic Level 3

(L/kg tissue) Trophic Level 4

(L/kg tissue)

Aldrin 309

- 00

- 2 17 0.00003 0.20 18,000 310,000 650,000

alpha

- Hexachlorocyclohexane

(HCH) 319

- 84

- 6 6.3 0.008 0.20 1,700 1,400 1,500

alpha

- Endosulfan 959

- 98

- 8 ND 0.006 0.20 130 180 200

Anthracene 120

- 12

- 7 ND 0.3 0.20 610* 610* 610*

Benzene 71

- 43

- 2 0.015

– 0.055 0.0005 0.20 3.6 4.5 5.0

Benzidine 92

- 87

- 5 230 0.003 0.20 1.4 1.6 1.7

Benzo(a) a nthracene 56

- 55

- 3 0.73 ND ND 3,900* 3,900* 3,900*

Benzo(a) p yrene 50

- 32

- 8 7.3 ND ND 3,900* 3,900* 3,900*

Benzo(b)fluoranthene 205

- 99

- 2 0.73 ND ND 3,900* 3,900* 3,900*

Benzo(k)fluoranthene 207

- 08

- 9 0.073 ND ND 3,900* 3,900* 3,900*

beta

- Hexachlorocyclohexane

(HCH) 319

- 85

- 7 1.8 ND ND 110 160 180

beta

- Endosulfan 33213

- 65

- 9 ND 0.006 0.20 80 110 130

Bis(2

- Chloro

- 1

- Methylethyl) Ether 108

- 60

- 1 ND 0.04 0.20 6.7 8.8 10

Bis(2

- Chloroethyl) Ether 111

- 44

- 4 1.1 ND ND 1.4 1.6 1.7

Bis(2

- Ethylhexyl) Phthalate 117

- 81

- 7 0.014 0.06 0.20 710* 710* 710*

Bis(Chloromethyl) Ether 542

- 88

- 1 220 ND ND 1.0 1.0 1.0

Bromoform 75

- 25

- 2 0.0045 0.03 0.20 5.8 7.5 8.5

Butylbenzyl Phthalate 85

- 68

- 7 0.0019 1.3 0.20 19,000* 19,000* 19,000*

Carbon Tetrachloride 56

- 23

- 5 0.07 0.004 0.20 9.3 12 14

Chlordane 57

- 74

- 9 0.35 0.0005 0.20 5,300 44,000 60,000

Chlorobenzene 108

- 90

- 7 ND 0.02 0.20 14 19 22

Chlorodibromomethane 124

- 48

- 1 0.040 0.02 0.20 3.7 4.8 5.3

Chloroform 67

- 66

- 3 ND 0.01 0.20 2.8 3.4 3.8

Chlorophenoxy Herbicide

(2,4

- D) 94

- 75

- 7 ND 0.21 0.20 13* 13* 13*

Chlorophenoxy Herbicide

(2,4,5

- TP) [Silvex] 93

- 72

- 1 ND 0.008 0.80 58* 58* 58*

## Chemical

- specific Inputs for EPA’s 2015 Final Updated Human Health Ambient Water Quality Criteria

3 Chemical Name CAS Cancer Slope

Factor, CSF

(per mg/kg

- d) Reference

Dose, RfD

(mg/kg

- d) Relative Source

Contribution, RSC

(

- ) Bioaccumulation Factor

Bioconcen

tration Factor

(L/kg tissue) Trophic Level 2

(L/kg tissue) Trophic Level 3

(L/kg tissue) Trophic Level 4

(L/kg tissue)

Chrysene 218

- 01

- 9 0.0073 ND ND 3,900* 3,900* 3,900*

Cyanide 57

- 12

- 5 ND 0.0006 0.20 ND ND ND 1 **

Dibenzo(a,h)anthracene 53

- 70

- 3 7.3 ND ND 3,900* 3,900* 3,900*

Dichlorobromomethane 75

- 27

- 4 0.034 0.003 0.20 3.4 4.3 4.8

Dieldrin 60

- 57

- 1 16 0.00005 0.20 14,000 210,000 410,000

Diethyl Phthalate 84

- 66

- 2 ND 0.8 0.20 920* 920* 920*

Dimethyl Phthalate 131

- 11

- 3 ND 10 0.20 4,000* 4,000* 4,000*

Di

- n

- Butyl Phthalate 84

- 74

- 2 ND 0.1 0.20 2,900* 2,900* 2,900*

Dinitrophenols 25550

- 58

- 7 ND 0.002 0.20 ND ND ND 1.51 **

Endosulfan Sulfate 1031

- 07

- 8 ND 0.006 0.20 88 120 140

Endrin 72

- 20

- 8 ND 0.0003 0.80 4,600 36,000 46,000

Endrin Aldehyde 7421

- 93

- 4 ND 0.0003 0.80 440 920 850

Ethylbenzene 100

- 41

- 4 ND 0.022 0.20 100 140 160

Fluoranthene 206

- 44

- 0 ND 0.04 0.20 1,500* 1,500* 1,500*

Fluorene 86

- 73

- 7 ND 0.04 0.20 230 450 710

gamma

- Hexachlorocyclohexane

(HCH) 58

- 89

- 9 ND 0.0047 0.50 1,200 2,400 2,500

Heptachlor 76

- 44

- 8 4.1 0.0001 0.20 12,000 180,000 330,000

Heptachlor Epoxide 1024

- 57

- 3 5.5 0.000013 0.20 4,000 28,000 35,000

Hexachlorobenzene 118

- 74

- 1 1.02 0.0008 0.20 18,000 46,000 90,000

Hexachlorobutadiene 87

- 68

- 3 0.04 0.0003 0.20 23,000 2,800 1,100

Hexachlorocyclohexane (HCH)

-
Technical 608

- 73

- 1 1.8 ND ND 160 220 250

Hexachlorocyclopentadiene 77

- 47

- 4 ND 0.006 0.20 620 1,500 1,300

Hexachloroethane 67

- 72

- 1 0.04 0.0007 0.20 1,200 280 600

Indeno(1,2,3

- cd)pyrene 193

- 39

- 5 0.73 ND ND 3,900* 3,900* 3,900*

Isophorone 78

- 59

- 1 0.00095 0.2 0.20 1.9 2.2 2.4

Methoxychlor 72

- 43

- 5 ND 0.00002 0.80 1,400 4,800 4,400

## Chemical

- specific Inputs for EPA’s 2015 Final Updated Human Health Ambient Water Quality Criteria

4 Chemical Name CAS Cancer Slope

Factor, CSF

(per mg/kg

- d) Reference

Dose, RfD

(mg/kg

- d) Relative Source

Contribution, RSC

(

- ) Bioaccumulation Factor

Bioconcen

tration Factor

(L/kg tissue) Trophic Level 2

(L/kg tissue) Trophic Level 3

(L/kg tissue) Trophic Level 4

(L/kg tissue)

Methyl Bromide 74

- 83

- 9 ND 0.02 0.20 1.2 1.3 1.4

Methylene Chloride 75

- 09

- 2 0.002 0.006 0.20 1.4 1.5 1.6

Nitrobenzene 98

- 95

- 3 ND 0.002 0.20 2.3 2.8 3.1

Pentachlorobenzene 608

- 93

- 5 ND 0.0008 0.20 3,500 4,500 10,000

Pentachlorophenol 87

- 86

- 5 0.4 0.005 0.20 44 290 520

Phenol 108

- 95

- 2 ND 0.6 0.20 1.5 1.7 1.9

p,p'

- Dichlorodiphenyldichloroethane

(DDD) 72

- 54

- 8 0.24 0.0005 0.20 33,000 140,000 240,000

p,p'

- Dichlorodiphenyldichloroethylene

(DDE) 72

- 55

- 9

0.167 0.0005 0.20 270,000 1,100,000 3,100,000

p,p'

- Dichlorodiphenyltrichloroethane

(DDT) 50

- 29

- 3 0.34 0.0005 0.20 35,000 240,000 1,100,000

Pyrene 129

- 00

- 0 ND 0.03 0.20 860* 860* 860*

Tetrachloroethylene

(Perchloroethylene) 127

- 18

- 4 0.0021 0.006 0.20 49 66 76

Toluene 108

- 88

- 3 ND 0.0097 0.20 11 15 17

Toxaphene 8001

- 35

- 2 1.1 0.00035 0.20 1,700 6,600 6,300

trans

- 1,2

- Dichloroethylene (DCE) 156

- 60

- 5 ND 0.02 0.20 3.3 4.2 4.7

Trichloroethylene (TCE) 79

- 01

- 6 0.05 0.0005 0.20 8.7 12 13

Vinyl Chloride 75

- 01

- 4 1.5 0.003 0.20 1.4 1.6 1.7

ND = No data.

* This bioaccumulation factor was estimated from laboratory

- measured bioconcentration factors ; EPA multiplied this bioaccumulation factor by the overall national

recommended fish consumption rate of 22.0 g/d (see EPA’s 2014 Estimated Fish Consumption Rates for the U.S. Population and Selected Subpopulations (NHANES 2003

- 2010) )

to calculate the 2015 final updated human health criteria

.

** EPA multi plied this bioconcentration factor by the overall national recommended fish consumption rate of 22.0 g/d (see EPA’s 2014 Estimated Fish Consumption Rates for the

U.S. Population and Selected Subpopulations (NHANES 2003

- 2010) ) to calculate the 2015 final updated human health criteria

.