### SAT Report PMN Number: P-12-0150 SAT Date: 1/27/2012 Print Date: 12/3/2013

Related cases : Health related cases : Ecotox related cases:

Concern levels : Type of Concern: Health Eco Comments Level of Concern: 1 3

Persistence Bioaccum Toxicity Comments 1 11

Exposure Based Review : Health: N o Ecotox: Yes
Routes of exposure : Health: N o exposures needed Ecotox: All releases to water Fate: ;

P 2 Rec Comments : Comment: Forward
Keywords : Keywords: AQUATOX-A,C
Summary of Assessment :
Fate : Fate Summary: P-12-0150log Fish BCF = 1.60 (E) log Fish BAF = 1.11 (E) POTW removal (%) = 90 via biodeg; OECD 301B (Mod Sturm CO2 ev): 91%/28d. Time for complete ultimate aerobic biodeg = wk Sorption to soils/sediments = low PBT Potential: P1B1 *CEB FATE: Migration to ground water = slow due to biodeg

Health : Health Summary: Absorption is poor all routes based on analogs. Expect p oor hydrolysis of the esters. N o significant health concerns. Low concern. Test Data: TOXICITY DATA for close analog negative in Salmonella with and without activation negative in oral rat micronucleus assay negative in mouse lymphoma cells with and without activation 14-day oral study in rats - no deaths or signs of toxicity at doses up to 2.3 g/kg slight eye irritant in rabbits slight dermal irritant in rabbits acute intravenous study in mice - no deaths at doses up to 2.3 g/kg; recumbent position, p iloerection, absence of spontaneous locomotor activity, decrease in muscle tone acute oral study in mice - no deaths or signs of toxicity at doses up to 2.3 g/kg acute intravenous study in rats - deaths a t 2.3 and 1.15 g/kg, no deaths at 0.575 g/kg; reduced spontaneous locomotor activity, absence of reactivity, decrease in body, abdominal, and limb tone at 0.575 g/kg acute oral study in rats - no deaths or signs of toxicity at doses up to 2.3 g/kg negative for dermal sensitization in the mouse local lymph node assay at 100% concentration oral developmental toxicity study in rats - no adverse effects at doses up to 2.3 g/kg ( 2 fetuses from the same litter had omphalocele/ p rotrusion of part of the intestine at the umbilicus) 90-day oral study in rats - reduced body weight gain in males at 1.15 and 2.3 g/kg; decrease in mobile spermatozoa ans total number of spermatozoa at 2.3 g/kg 28-day oral study in rats - N OAEL = 2.3 g/kg oral developmental toxicity study in rats - marginal reduction in ossification and reduced fetal weights ay 2.3 g/kg oral absorption and excretion study in rats - half-life = 1.9 to 3.4 hours

Ecotox :
Test Organism Test Type Test End Point Predicted Measured Comments

fish 96-h LC50 * daphnid 48-h LC50 * > 100 (invalid) green algal 96-h EC50 0.099 fish

_ chronic value 0.010daphnid

_ chronic value 0.097
algal

_ chronic value 0.089
Sewage Sludge 3-h EC50

_ Sewage Sludge

_ Chronic Value _

Ecotox Values Comments: Predictions are based on SARs for esters; SAR chemical class = ester; MW 399; p H7; effective concentrations based on 100% active ingredients and mean measured concentrations; hardness <150.0 mg/L as CaCO3; and TOC <2.0 mg/L;

Factors Values Comments Assessment Factor 10 Concentration of Concern ( p pb) 1

SARs esters SAR Class ester Ecotox Category Esters

Ecotox Factors Comments:

SAT Chair: L Keifer 564-8916