CBM 2004-2 

Celiac Disease 

January 1986 through March 2004 

2382 Citations 

Prepared by 

Karen Patrias, M.L.S., National Library of Medicine 

Carolyn C. Willard, M.L.S., National Library of Medicine 

Frank A. Hamilton, M.D., M.P.H., National Institute of Diabetes and Digestive and Kidney Diseases 

2004 June 

US DEPARTMENT OF HEALTH 

 AND HUMAN SERVICES 

Public Health Service 

National Institutes of Health 

National Library of Medicine 

Reference Section 

8600 Rockville Pike 

Bethesda, Maryland 20894 
ii

SERIES NOTE 

Each bibliography in the Current Bibliographies in Medicine (CBM) series covers a distinct subject area of 

biomedicine and fulfills a current awareness function. Online databases and the Internet are the primary 

sources for citations in these bibliographies. Relevance to the subject is the only criterion for inclusion of 

works in a CBM; the format, ownership, or location of the material are not considered. 

Other publications in the Current Bibliographies in Medicine series are available through the Library's 

World Wide Web site at http://www.nlm.nih.gov/pubs/resources.html Comments and suggestions on this

series may be addressed to: 

 Karen Patrias, Editor 

 Current Bibliographies in Medicine 

 Reference Section 

 National Library of Medicine 

 Bethesda, MD 20894 

 Phone: 301-496-6097 

 E-mail: custserv@nlm.nih.gov

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iii

TABLE OF CONTENTS 

 page 

 

 Introduction v

 Sample Citations vi

 

OVERVIEWS/BACKGROUND 1 

 DIAGNOSIS 

 General 27 

 Diagnostic Tests 

 Anti-endomysial Antibodies (EMA) 35 

 Human Tissue Transglutaminase IgA Antibodies (TTG) 46 

 Anti-gliadin Antibodies (AGA) 57 

 Human Leukocyte Antigens (HLA) 68 

 Small Bowel Biopsy 79 

 Differential Diagnosis 89 

 Clinical Manifestations 

 Dermatologic 94 

 Gastrointestinal 101 

 Neuropsychologic 103 

 Other 110 

 Other 121 

 INCIDENCE AND PREVALENCE 

 Genetics 136 

 Special Populations 

 An Affected Family Member 146 

 Type I Diabetes 148 

 Iron Deficiency Anemia 155 

 Osteoporosis 157 

 Geographic Distribution 161 

 Other 168 

 ASSOCIATION WITH CANCER AND OTHER TUMORS 

 General 173 

 Lymphoma 175 

 Adenocarcinoma 178 

 Other Cancers/Tumors 179 

 SCREENING 

 General 179 

 Asymptomatic Individuals 182 

 Special Populations 183 

 THERAPY 

 Gluten-free Diet 185 

 Other 197 

 REFRACTORY SPRUE 199 

 

 
iv
v

INTRODUCTION 

Celiac disease is a disorder primarily affecting the gastrointestinal tract that is characterized by chronic 

inflammation of the mucosa, which leads to atrophy of intestinal villi, malabsorption, and protean clinical 

manifestations which may begin either in childhood or adult life. Symptoms can include abdominal 

cramping, bloating, and distention, and untreated celiac disease may lead to vitamin and mineral 

deficiencies, osteoporosis and other problems. The disease is also strongly associated with the skin 

disorder, dermatitis herpetiformis. Celiac disease's major genetic risk factors (HLA-DQ2 and HLA-DQ8), 

and environmental trigger (specific peptides present in wheat, rye and barley) have been identified and 

most patients experience complete remission after exclusion of these grains from the diet. Thus, there has 

been considerable scientific progress in understanding this complex disease and in preventing or curing its 

manifestations by dietary interventions. 

At the present time, celiac disease is widely considered to be a rare disease in the United States. However, 

recent studies, primarily in Europe but also in the United States, suggest that its prevalence is much higher 

than previous estimates, raising the concern that the disease is widely under-recognized. Recent progress in 

identification of autoantigens in celiac disease have led to the development of new serological diagnostic 

tests, but the appropriate use of testing strategies has not been well defined. Some patients with celiac 

disease may be at risk for non-Hodgkin's lymphoma, a rare cancer affecting the gastrointestinal tract. It is 

not yet clear, however, what the impact of this observation should be on diagnostic and treatment strategies. 

This bibliography has been prepared for a National Institutes of Health Consensus Development 

Conference on Celiac Disease held June 28-30, 2004, in Bethesda, Maryland. This conference was 

sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the 

Office of Medical Applications of Research (OMAR). Specifically, the conference will address the 

following key questions: 

• How is celiac disease diagnosed? 

• How prevalent is celiac disease? 

• What are the manifestations and long-term consequences of celiac disease? 

• Who should be tested for celiac disease? 

• What is the management of celiac disease? 

• What are the recommendations for future research on celiac disease and related conditions? 

Citations for this bibliography were selected from a search of relevant online databases. It contains 

references to English-language journal articles published from 1986 through March 2004. Letters to the 

editor, meeting abstracts, and single case reports were excluded. References have been arranged into 

subject categories that reflect the topics discussed at the Conference; a citation may appear under more than 

one category. 

The compilers wish to thank Phyllis Levine, National Library of Medicine, for her valuable production 

assistance. 

This bibliography is not copyrighted and may be freely reproduced. However any reproductions of this 

bibliography, in whole or in part, should include all credits. If you wish to cite this bibliography, the correct 

format is: 

Patrias, Karen; Willard, Carolyn C.; Hamilton, Frank A., compilers. Celiac disease [bibliography]. 

Bethesda (MD): National Library of Medicine (US); 2004 Jun. 2382 citations from January 1986 through 

March 2004. 
vi

SAMPLE CITATIONS 

Citations are formatted according to the rules established for Index Medicus®*. A sample journal citation 

appears below. 

Note also for journal articles than an availability statement follows many citations. This statement contains 

the identification number (PMID) for the citation in the NLM PubMed retrieval system. The user may enter 

this number in PubMed on the NLM Web site (http://pubmed.gov/) to retrieve the record, which includes 

an abstract for most articles and may also provide a link to the publisher's Internet site. 

 Journal Article: 

 Auricchio S, Greco L, Troncone R. Gluten-sensitive enteropathy in childhood. Pediatr Clin North 

 Am. 1988 Feb;35 (1):157-87. Available from: PubMed; PMID 3277130 

 Order, with separating punctuation: 

 Author 1, Author 2, Author 3. Article Title. Abbreviated Journal Title. 

 Date;Volume(Issue):Pages. Availability. 

______________ 

 * For details of the formats used for references, see the following publications: 

 Patrias, Karen. National Library of Medicine recommended formats for bibliographic citation. 

 Bethesda (MD): The Library; 1991 Apr. Available from: 

 http://www.nlm.nih.gov/pubs/formats/recommendedformats.html 

 Patrias, Karen. National Library of Medicine recommended formats for bibliographic citation. 

 Supplement: Internet formats. Bethesda (MD): The Library; 2001 Jul. Available from: 

 http://www.nlm.nih.gov/pubs/formats/recommendedformats.html 
1

OVERVIEWS/BACKGROUND 

Abdulkarim AS, Murray JA. Celiac disease. Curr 

Treat Options Gastroenterol. 2002 Feb;5(1):27-

38. Available from: PubMed; PMID 11792235 

 

Abdulkarim AS, Murray JA. Review article: the 

diagnosis of coeliac disease. Aliment Pharmacol 

Ther. 2003 Apr 15;17(8):987-95. Available 

from: PubMed; PMID 12694080 

 

Achyuthan KE, Goodell RJ, Kennedye JR, Lee 

KN, Henley A, Stiefer JR, Birckbichler PJ. 

Immunochemical analyses of human plasma 

fibronectin-cytosolic transglutaminase 

interactions. J Immunol Methods. 1995 Mar 

13;180(1):69-79. Available from: PubMed; 

PMID 7534805 

 

Aleanzi M, Demonte AM, Esper C, Garcilazo S, 

Waggener M. Celiac disease: antibody 

recognition against native and selectively 

deamidated gliadin peptides. Clin Chem. 2001 

Nov;47(11):2023-8. Available from: PubMed; 

PMID 11673371 

 

Alfonso P, Soto C, Albar JP, Camafeita E, 

Escobar H, Suarez L, Rico M, Bruix M, Mendez 

E. Beta structure motif recognition by antigliadin antibodies in coeliac disease. FEBS Lett. 

1998 May 1;427(1):36-40. Available from: 

PubMed; PMID 9613595 

 

Alpers DH. Another piece to the celiac puzzle. J 

Pediatr Gastroenterol Nutr. 1987 Jan-Feb;6(1):5-

7. Available from: PubMed; PMID 3794933 

 

Altmann DM, Sansom D, Marsh SG. What is the 

basis for HLA-DQ associations with 

autoimmune disease? Immunol Today. 1991 

Aug;12(8):267-70. Available from: PubMed; 

PMID 1910448 

 

American Gastroenterological Association 

medical position statement: Celiac Sprue. 

Gastroenterology. 2001 May;120(6):1522-5. 

Available from: PubMed; PMID 11313323 

 

American Gastroenterological Association 

medical position statement: guidelines on 

osteoporosis in gastrointestinal diseases. 

Gastroenterology. 2003 Mar;124(3):791-4. 

Available from: PubMed; PMID 12612916 

 

Anderson RP, Degano P, Godkin AJ, Jewell DP, 

Hill AV. In vivo antigen challenge in celiac 

disease identifies a single transglutaminasemodified peptide as the dominant A-gliadin Tcell epitope. Nat Med. 2000 Mar;6(3):337-42. 

Available from: PubMed; PMID 10700238 

 

Antonioli DA. Celiac disease: a progress report. 

Mod Pathol. 2003 Apr 1;16(4):342-6. Available 

from: PubMed; PMID 12692199 

 

Are your GI symptoms linked to wheat? Johns 

Hopkins Med Lett Health After 50. 2003 

Jul;15(5):3,7. Available from: PubMed; PMID 

12838912 

 

Ascher H. Paediatric aspects of coeliac disease: 

old challenges and new ones... Dig Liver Dis. 

2002 Mar;34(3):216-24. Available from: 

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Ashkenazi A. Living with celiac disease. Child 

Hosp Q. 1989;1(3):265-71. 

 

Astill TP, Ellis RJ, Arif S, Tree TI, Peakman M. 

Promiscuous binding of proinsulin peptides to 

Type 1 diabetes-permissive and -protective HLA 

class II molecules. Diabetologia. 2003 

Apr;46(4):496-503. Available from: PubMed; 

PMID 12684749 

 

Auricchio S, Greco L, Troncone R. Glutensensitive enteropathy in childhood. Pediatr Clin 

North Am. 1988 Feb;35(1):157-87. Available 

from: PubMed; PMID 3277130 

 

Auricchio S, Troncone R, Maurano F. Coeliac 

disease in the year 2000. Ital J Gastroenterol 

Hepatol. 1999 Nov;31(8):773-80. Available 

from: PubMed; PMID 10730570 
2 

 

Austin AS, Logan RF, Thomason K, Holmes 

GK. Cigarette smoking and adult coeliac disease. 

Scand J Gastroenterol. 2002 Aug;37(8):978-82. 

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Bai J, Moran C, Martinez C, Niveloni S, Crosetti 

E, Sambuelli A, Boerr L. Celiac sprue after 

surgery of the upper gastrointestinal tract. Report 

of 10 patients with special attention to diagnosis, 

clinical behavior, and follow-up. J Clin 

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Balas A, Garcia-Novo MD, Martinez J, GarciaSanchez F, Santos S, Vicario JL. Intestinal 

alphabeta T cells of symptomatic celiac disease 

patients show oligoclonal TCRBV repertoire but 

polyclonal rearrangement patterns. Hum 

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Bansal AS, Bruce J, Thomson A, Kerlin P. 

Serum levels of sCD23, interleukin-10 and 

interferon-gamma in patients with coeliac 

disease. J Gastroenterol Hepatol. 1997 Oct;12(9-

10):685-9. Available from: PubMed; PMID 

9407334 

 

Barbato M, Miglietta MR, Viola F, Iulianella 

VR, Frediani T, Lucarelli S, Tozzi AE, Cardi E. 

Impact of modification of diagnostic techniques 

and criteria on the presentation of celiac disease 

in the last 16 years. Observation in Rome. 

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Barnes RM, Harvey MM, Blears J, Finn R, 

Johnson PM. IgG subclass of human serum 

antibodies reactive with dietary proteins. Int 

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Barr G, Cameron D, King S, Ryan J, Selby W, 

Shepherd S, Tobin J, Pan C. Current status and 

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Barr GD, Grehan MJ. Coeliac disease. Med J 

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Beaumont DM, Mian MS. Coeliac disease in old 

age: 'a catch in the rye'. Age Ageing. 1998 

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Beckett CG, Ciclitira PJ. Celiac disease. Curr 

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Beckett CG, Dell'Olio D, Ellis HJ, RosenBronson S, Ciclitira PJ. The detection and 

localization of inducible nitric oxide synthase 

production in the small intestine of patients with 

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1998 Aug;10(8):641-7. Available from: 

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Beckett CG, Dell'Olio D, Schidrawi RG, RosenBronson S, Ciclitira PJ. Gluten-induced nitric 

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Bentley AC. A survey of celiac-sprue patients: 

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Bernstein CN, Leslie WD. The pathophysiology 

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Biagi F, Corazza GR. Clinical features of coeliac 

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Biagi F, Corazza GR. Gene and gliadin/gut and 

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Oct;97(10):2486-8. Comment on: Am J 

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3

Biagi F, Ellis HJ, Parnell ND, Shidrawi RG, 

Thomas PD, O'Reilly N, Corazza GR, Ciclitira 

PJ. A non-toxic analogue of a coeliac-activating 

gliadin peptide: a basis for immunomodulation? 

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Biagi F, Zimmer KP, Thomas PD, Ellis HJ, 

Ciclitira PJ. Is gliadin mispresented to the 

immune system in coeliac disease? A hypothesis. 

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Bianchi ML, Bardella MT. Bone and celiac 

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Black KE, Murray JA, David CS. HLA-DQ 

determines the response to exogenous wheat 

proteins: a model of gluten sensitivity in 

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Bontems P, Deprettere A, Cadranel S, 

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Borch K, Grodzinsky E, Petersson F, Jonsson KA, Mardh S, Valdimarsson T. Prevalence of 

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adult population sample: A histomorphological 

and serological survey. Inflammopharmacology. 

2000;8(4):341-50. 

 

Borner H, Osman AA, Meergans T, Weiske T, 

Mothes T. Isolation of antigens recognized by 

coeliac disease autoantibodies and their use in 

enzyme immunoassay of endomysium and 

reticulin antibody-positive human sera. Clin Exp 

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Bottaro G, Failla P, Rotolo N, Sanfilippo G, 

Azzaro F, Spina M, Patane R. Changes in coeliac 

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Braegger CP, MacDonald TT. The immunologic 

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Brandtzaeg P. Immunologic basis for celiac 

disease, inflammatory bowel disease, and type B 

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Branski D, Troncone R. Celiac disease: a 

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Camarero C, Eiras P, Asensio A, Leon F, 

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Cardenas A, Kelly CP. Celiac sprue. Semin 

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Carlsson AK, Lindberg BA, Bredberg AC, 

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Carter MJ, Willcocks MM, Mitchison HC, 

Record CO, Madeley CR. Is a persistent 

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Catassi C, Fornaroli F, Fasano A. Celiac disease: 

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Catassi C, Ratsch IM, Fabiani E, Rossini M, 

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343(8891):188; Lancet. 1994 Mar 12; 

343(8898):675; Lancet. 1995 Jul 1; 

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Ciccocioppo R, D'Alo S, Di Sabatino A, Parroni 

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Ciccocioppo R, Di Sabatino A, Parroni R, D'alo 

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Ciccocioppo R, Di Sabatino A, Parroni R, Muzi 

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Ciclitira PJ. Coeliac disease: foreword. Dig Liver 

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Ciclitira PJ. Recent advances in coeliac disease. 

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Ciclitira PJ, Ellis HJ. In vivo gluten ingestion in 

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Ciclitira PJ, Hall MA. Coeliac disease. Baillieres 

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5

Ciclitira PJ, King AL, Fraser JS. AGA technical 

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Ciclitira PJ, Moodie SJ. Transition of care 

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Ciclitira PJ, Sturgess R. Clinicopathologic 

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Clemente MG, Musu MP, Frau F, Brusco G, 

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Collin P, Kaukinen K, Valimaki M, Salmi J. 

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Collin P, Pukkala E, Reunala T. Malignancy and 

survival in dermatitis herpetiformis: a 

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Collin P, Reunala T, Pukkala E, Laippala P, 

Keyrilainen O, Pasternack A. Coeliac disease--

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PMID 7959226 

 

Collin P, Reunala T, Rasmussen M, Kyronpalo 

S, Pehkonen E, Laippala P, Maki M. High 

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Colombel JF, Torpier G, Janin A, Klein O, 

Cortot A, Capron M. Activated eosinophils in 

adult coeliac disease: evidence for a local release 

of major basic protein. Gut. 1992 

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PMID 1427370 

 

Colston KW, Mackay AG, Finlayson C, Wu JC, 

Maxwell JD. Localisation of vitamin D receptor 

in normal human duodenum and in patients with 

coeliac disease. Gut. 1994 Sep;35(9):1219-25. 

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Cook HB, Burt MJ, Collett JA, Whitehead MR, 

Frampton CM, Chapman BA. Adult coeliac 

disease: prevalence and clinical significance. J 

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Coppo R, Mazzucco G, Martina G, Roccatello 

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Sena LM. Gluten-induced experimental IgA 

glomerulopathy. Lab Invest. 1989 

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PMID 2709812 

 

Corazza G, Valentini RA, Frisoni M, Volta U, 

Corrao G, Bianchi FB, Gasbarrini G. Gliadin 

immune reactivity is associated with overt and 

latent enteropathy in relatives of celiac patients. 

Gastroenterology. 1992 Nov;103(5):1517-22. 

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Corazza GR, Andreani ML, Biagi F, Corrao G, 

Pretolani S, Giulianelli G, Ghironzi G, 

Gasbarrini G. The smaller size of the 'coeliac 

iceberg' in adults. Scand J Gastroenterol. 1997 

Sep;32(9):917-9. Available from: PubMed; 

PMID 9299671 

 

Corazza GR, Biagi F, Volta U, Andreani ML, De 

Franceschi L, Gasbarrini G. Autoimmune 

enteropathy and villous atrophy in adults. 

Lancet. 1997 Jul 12;350(9071):106-9. Comment 
6 

in: Lancet. 1997 Sep27;350(9082):959-60. 

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