U.S. ENVIRONMENTAL PROTECTION AGENCY 

PREMANUFACTURE 

NOTICE 

:S 

1\.1;;1 UlII:' UJta.1 uUll.lVQ.l V.l pa5"';:} ........ in the Premanufac1ure Notice 

Form 

AGENCY USE ONLY Date Dfreceipt 

Company Sanitized 

GENERAL INSTRUCTIONS 

You must provide all infonnation requested in this form to the extent that it is known to or reasonably ascertainable by you. Make reasonable estimates if you do 


not have actual data. 


Before you complete this form, you should read the "Instructions Manual for Premanufacture Notification" (the Instructions Manual is available from the Toxic 


Substances Control Act (TSCA) Information Service by calling 202-554-1404, or faxing 202-554-5603). 


Ifa user fee has been remitted for this notice (40 CFR 700.45), indicate in the boxes above the TS-user fee identification number you have generated. Remember, your user fee 

ID number must also appear on your corresponding fee remittance, which is sent to EPA, HQ Accounting Operations Branch (PM-226), P.O. 360399M, Pittsburgh, PA 

15251-6399, Attn. TSCA User fee. 

Part I~ GENERAL INFORMATION 

You must provide the currently correct Chemical Abstracts (CA) Name of the new 

chemical substance, even ifyou claim the identity as confIdentiaL You may authorize 

another person to submit chemical identity information for you, but your submIssion will 

not be complete and the review will not begin until EPA receives this information A 

letter in support of your submission should reference your TS user fee identifIcation 

number. You must submit an original and two copies of this notice including all test data 

Ifyou claimed any information as con:tidential, a single sanitized copy must also be 

submitted 

Part II HUMAN EXPOSURE AND ENVIRONMENTAL RELEASE 

Ifthere are several manufacture, processing, or use operations to be described in Part II, 

sections A and B ofthis notice, reproduce the sections as needed. 

Part III LIST OF ATTACHMENTS 

Attach additional sheets if there is not enough space to answer a question fully. Label 

each continuation sheet with the corresponding section heading. In Part III, list these 

attachments, any test data or other data and any optional information included in the 

notIce. 

OPTI ONAL INFORMATION 

You may include any information that you want EPA to consider in evaluating the new 

substance. On page 11 of this fonn, space has been provided for you to described 

pollution prevention and recycling information you may have regarding the new 

substance. 

So-called "binding" boxes are included throughout this form for you to indicate your 

willingness to be bound to certain statements you make in this section, such as use, 

production volume, protective equipment. This option is intended to reduce delays 

that routinely accompany the development of consent orders or SignifIcant New Use 

Rules. Except in the case ofexemption applications (such as TMEA, L VE, LOREX) 

where certain information provided in such notification is binding on the submitter when 

the Agency approves the exemption application, checking a binding box in this notice 

does not by itself prohibIt the submitter from later deviating from the information (except 

chemical identity) reported in the form. 

CONFIDENTIALITY CLAIMS 

You may claim any information in this notice as confidential. To assert a claim on the 

fonn, mark (X) the confIdential box next to the information that you claim as 

confidential. To assert a claim in an attachment, circle or bracket the information you 

claim as confidentiaL If you claim information in the notices. as confidential you must 

also provide a sanitized version of the notice (including attachments). For additional 

instructions on claimIng information as confidential, read the Instructions Manual. 

k8J Mark (x) ifany information in this notice is claimed as confidential. 

TEST DATA AND OTHER DATA 

You are required to submit all test data in your possession or control and to provide 

a description ofall other data known to or reasonably ascertainable by you, if these 

data are related to the health and environmental effects on the manufacture, 

processing, distribution in commerce, use, or disposal of the neW chemical 

substance. Standard literature citations may be submitted for data in the open 

scientific literature. Complete test data (written in English), not summaries ofdata, 

must be submitted if they do not appear in the open literature. You should clearly 

identify whether test data is on the substance or on an analog. Also, the chemical 

composition of the tested material should be characterized. Following are 

examples oftest data and other data. Data should be submitted according to the 

requirements of §720.50 ofthe Premanufacture Notification Rule (40 CFR Part 

720). 

Test Data (Check Below any included in this notice) 

Environmental fate data 181 Yes 	 Other data 181 Yes 

Health effects data 181 Yes 	 Risk assessments 

Environmental effects data 181 Yes 	 Structure/activity relationships 

Physical/Chemical Properties. 181 Yes 	 Test data not in the possessIOn 

or control ofthe submitter 

• A pbysical and chemical properties worksheet is located on the last page ofthis fonn. 

TYPE OF NOTICE (Check Only One) 

~ PMN (Premanufacture Notice) 

D INTERMEDIATE PMN (submitted in sequence with final product PMN) 

D SNUN (Significant New Use Notice) 

D TMEA (Test Marketing Exemption Application) 

D LVE (Low Volume Exemption)@40 CFR 

D LOREX (Low Release/Low Exposure Exemption) @ 4Q~R n3.50(c){2) 

D LVE Modification D LOREX Moctif!liation 

IS THIS A CONSOLIDATED PMN? D Yes

# of chemi cals 


(Prenotice Communication # required, enter # on page 3) 


~DAFORM7710-25 (Rev. 5-95) Replaces previous editions of EPA Form 7710-25. IIB"V:' 

_IDENTIAl8USINOI INFORMATION J 
Public reporting burden for this collection of information is estimated to average 110 hours per response, including time tor reviewing 

instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of 

information. Send comments regarding the burden estimate or any other aspect of this collection of information, including suggestions for 

reducing this burden, to Cruet: Information Policy Branch, PM-223, U.S. Environmental Protection Agency, 40 1 M St, S. W., Washington, D.C. 

20460; and to the Office oCManagement and Budget, Paperwork Reduction Act (2070-0012), Washington, D.C. 20503. 

CERTIFICATION 


I certify that to the best of my knowledge and belief: 

1. 	 The company named in Part I, section A, subsection la of this notice form intends to manufacture or import for a 

commercial pwpose, other than in small quantities solely for research and development, the substance identified in Part I, 

Section B. 

2. 	 All information provided in this notice is complete and truthful as of the date of submission. 

3. 	 I am submitting with this notice all test data in my possession or control and a description of all other data known to or 

reasonably ascertainable by me as required by §720.50 of the Premanufacture Notification Rule. 

Additional Certification Statements: 

If you are submitting a PMN, Intermediate PMN, Consolidated PMN, or SNUN, check the following user fee certification 

statement that applies: 

(8J The Company named in Part I, Section A has remitted the fee of $2500 specified in 40 CFR 700.45(b), or 

o The Company named in Part I, Section A has remitted the fee of $1000 for an Intermediate PMN (defined @40 CFR 

700.43) in accordance with 40 CFR 700.45(b), or 

o The Company named in Part I Section A is a small business concern under 40 CFR 700.43 and has remitted a fee ofS1OO 

in accordance with 40 CFR 700.45(b). 

Ifyou are submitting a low volume exemption (LYE) application in accordance with 40 CFR 723.50(c)(I) or a Low release 

and low exposure exemption (LoRex) application in accordance with 40 CFR 723.50( c)(2) , check the following certification 

statements: 

o The manufacturer submitting this notice intends to manufacture or import the new chemical substance for commercial 

purposes, other than in small quantities solely for research and development, under the terms of 40 CFR 723.50. 

o 	The manufacturer is familiar with the terms of this section and will comply with those terms; and 

o 	The new chemical substance for which the notice is submitted meets all applicable exemption conditions. 

o Ifthis application is for an LVE in accordance with 40 CFR 723.50(c)(1), the manufacturer intends to commence 

manufacture of the exempted substance for commercial pwposes within 1 year of the date of the expiration of the 30 day 

review period. 

Conndential 

Signature of agent - (if applicable) Date 

EPA FORM 7710-25 (Rev. 5-95) 	 Page 2 
la. Person 

Submitting 

Notice (in U.S.) 

b. Agent (if 

applicable) 

Company 

Industries Inc. 

Mailmg address (number and street) 

aza 

NJ 

amnO)rtZf:a official 

Company 

Mailing address (number and street) 

City, State, ZIP Code 

c. If you are submitting this notice as part submission, mark 

Joint Submitter (if 

applicable) 

2. 

3. 

Contact (in 

U.S.) 

Company 

street) 

City, State, ZIP Code 

Name of 

Company 

CYTEC Industries Inc. 

Mailing address (number and street) 

5 

City, State, ZIP Code 

West Paterson, NJ 07424 

If you have had a prenotice conununication concerning this notice 

and EPA assigned a PC Number to the notice, enter the number. 

Telephone 

box. ______________________________________~ 

Telephone 

Position 

Americas 

Telephone 

Mark 

ifnone 

(X) ~ ~ 

Mark (X) .. ifnone 

4. 	 Ifyou previously submitted an exemption application for the chemical 

substance covered by this notice, enter the exemption number assigned by 

EPA If you previously submitted a PMN for this substance enter the 

PMN number assigned by EPA (i.e. withdrawn or incomplete). .. 

5. 

for the chemical substance covered by this notice, enter the notice number 

assigned by EPA. .. 

1. 	 Manufacture 

6. Type ofNotice - Mark (X) Only 

D Binding Option 

Mark 

Mark (X) .. ifnone 

2. 	 Import 

Only 3. 	 Both 

D 	 Binding Option 


Mark 


D 

EPA FORM 7710-25 (Rev. 5·95) 	 Page 3 
1. 

Complete either item I (Class I or 2 substances) or 2 (Polymers) as appropriate. Complete all other items. 

a. Class ofsubstance· Mark (X) or 

Instructions Manual) 

Class 2 

,-,,,,eHlI'''''' name correct Abstracts (CA) Name that is consistent with TSCA Inventory listings substances. 

For Class I substances a CA Index Name must be provided. For Class 2 substances either a CA Index Name or CA Preferred Name must 

be provided, which ever is appropriate based on CA 9CI nomenclature rules and conventions). 

c. Please you used to develop or notice: (check one). 

r:8J Method I (CAS Inventory Expert Service a copy ofthe Identification 0 Method 2 (Other Source) 

report obtained from the CAS Inventory Expert Services must be 

submitted as an attachment to this 

d Molecular formula and CAS Registry Number (ifa number already exists for the substance) 

e. For a class 1 substance, provide a complete and correct chemical structure diagram. For a class 2 substance - (1) List the immediate 

precursor substances with their respective CAS Registry Numbers. (2) Describe the nature ofthe reaction or process. (3) Indicate the 

range of composition and the typical composition (where appropriate). (4) Provide a correct representative or partial chemical structure 

diagram, as complete as can be known, if one can be reasonably ascertained. 

based on 

Confi· 

dential 

x 

x 

x 

x 

x 

o Mark (X) this box if you attach a continuation sheet. 

EPA FORM 7710·25 (Rev. 5·95) Page 4 
2. Confi­ Polymers (For a definition of polymer, see the Instructions Manual.) Not Applicable rNA) dential 

a. 	 Indicate the number-average weight ofthe lowest molecular weight composition ofthe polymer you intend to manufacture. 

Indicate maximum weight percent of low molecular weight species (not including residual monomers, reactants, or solvents) below 500 and 

below 1,000 absolute molecular weight ofthat composition. 

Describe the methods of measurement or the basis for your estimates: GPC 0 Other 0: (Specify) 

i) lowest number average molecular weight: 

ii) 	 maximum weight % below 500 molecular weight: 

iii) 	 maximum weight % below 1000 molecular weight: 

You must make separate 

attach a continuation sheet. 

claims for monomer or other reactant identity, composition information, and residual information. Mark (X) 

"Confidential" box next to any item you claim as confidential 

(1) 	 - Provide the specific chemical name and CAS Registry Number (ifa number exists) of each monomer or other reactant used in the manufacture of 

the polymer. 

(2) 	 Mark (X) this column if entry in column (1) is confidential. 

(3) 	 Indicate the typical weight percent of each monomer or other reactant in the polymer. 

(4) 	 Mark (X) the identity column if you want a monomer or other reactant used at two weight percent or less to be listed as part of the polymer 

desLTiption on the TSCA Chemical Substance Inventory. 

(5) 	 Mark (X) this column if entries in columns (3) and (4) are confidential. 

(6) 	 Indicate the maximum weight percent of each monomer or other reactant that may be present as a residual in the polymer as manufactured for 

commercial purposes. 

applicable to this PMN 

% % 

% % 

% % 

% % 

% % 

% % 

Mark this column if is confidential. 

Maximum 

Please identify which method you used to develop or obtain the specified chemical identity information reported in this notice (check one). 

Method 2 (other source) 

one can be reasonably ascertained. 

Page 5 

c. 

o 	Method 1 (CAS Inventory Expert Service - a copy ofthe identification report 0 

obtained from CAS Inventory Expert Service must be submitted as 

as attachment to this 

d. 	 The currently correct Chemical Abstracts (CA) name for the polymer that is consistent with TSCA Inventory 

e. 	 Provide a correct representative or partial chemical structure diagram, as complete as can be known, 

Mark (X) this box if you attach a continutation sheet 

EPA FORM 7710-25 (Rev. 5-95) 
(a) Identify each impurity that may be reasonably anticipated to be present in the chemical substance as manufactured for commercia! purpose. Provide the 

CAS Registry Number if available. Ifthere are unidentified impurities, enter "unidentified." 

Estimate the maximum % of each' Ifthere are unidentified' estimate their total 

4. Synonyms - Enter any chemical synonyms for the new chemical identified in subsection I or 2. 

o Mark (X) this box if you attach a continuation sheet. 

5. Trade identification List trade names for the new chemical substance identified in subsection I or 2. 

AERO® 5715 Promoter 

o Mark (X) this box if you attach a continuation sheet. 

6. Generic chemical name ­ claim chemical dential, you must provide a generic name for your substance that reveals 

the specific chemical identity ofthe new chemical substance to the maximum extent possible. Refer to the 

TSCA Chemical Substance Inventory, 1985 Edition, Appendix B for guidance on developing generic names. 

Thionocarbamate derivative or modified thionocarbamate. 

this box ifyou attach a continuation sheet. 

% 

% 

% 

% 

dential 

x 

x 

x 

Confidential 

x 

Describe any bypro ducts from the manufacture, processing, use, or new chemical substance. Provide the CAS Registry 

Number if available. 

None 

Mark (X) this box if you attach a continuation sheet. 

EPA FORM 7710-25 (Rev. 5-95) 

CAS 

Page 6 

Number Confidential 
Part I -- GENERAL INFORMATION -- Continued 

• Section C -- PRODUCTION. IMPORT, AND USE INFORMATION: 

Mark (X) the "Confidential" box next to any item you claim as confidential. 

1. Production volume ­ Estimate the maximum production volume during the first 12 months of production. Also estimate the maximum 

production volume for any consecutive 12-month period during the first three years ofproduction. Estimates should be on 100% new chemical 

substance basis. For a Low Volume Exemption application, if you choose to have your notice reviewed at a lower production volume than 

IO,O(}O kglyr, specify the volume and mark (x) in the binding box. Ifgranted, you are bound to this volume 

Maximum flrst 12-month production (kglyr) Maximum 12-month production (kglyr) Confi- Binding I 

(100% new chemical substance basis) (100% new chemical substance basis) dential Option 

Mark (x) 

X 

2. Use Information -- You must make separate confidentiality claims for the description of the category of use, the percent of production volume 

devoted to each category, the formulation of the new substance, and other use information. Mark (X) the "Confidential" Box next to any item 

you claim as confidential. 

a. (1) -­ Describe each intended category of use ofthe new chemical substance by function and application .. 

(2) ­ Mark (X) this column ifentry column (1) is confidential business information (CEl). 

(3)­ Indicate your willingness to have the information provided in column (I) binding. 

(4) Estimate the percent oftotal production for the first three years devoted to each category of use. 

(5) -­ Mark (X) this column ifentry in column (4) is confidential business information (CEl). 

(6) -­ Estimate the percent ofthe new substance as formulated in mixtures, suspensions, emulsions, solutions, or gels as manufactured for 

commercial purposes at sites under your control associated with each category of use. 

(7) -­ Mark (X) this column if entry in column (6) is confidential business information (CBl). 

(8) Indicate % ofproduct volume expected for the listed "use" sectors. Mark more than one box ifappropriate. Mark eX) to indicate 

your willingness to have the use type provided in (8) binding. 

(9) -­ Mark eX) this column ifentry(ies) in column (8) is (are) confidential business information (CBI). 

Category ofuse (I) CBI Bindin Produc- CBI %in CBI % ofsubstance expected per use CBI g tion% Form­ (8) Option 

(by function and application i.e. a dispersive dye Mark ulation Site- Con-* Indus- Com- Binding 

for finishing polyester fibers) (2) (x) (4) (5) (6) (7) limited sumer trial mercial Option (9) (3) 

X X X X 

% 

% 

% 

% 

% 

% 

% 

% 

% 

% 

% 

% 

* Ifyou have identified a "consumer" use, please provide on a continuation sheet a detailed description ofthe use(s) ofthis chemical substance in consumer products. 

In addition include estimates ofthe concentration ofthe new chemical substance as expected in consumer products and deseribe the chemical reactions by which this 

substance loses its identity in the consumer product. 

DMark (X) this box if you attach a continuation sheet. 

b. Generic Ifyou claim any category of use deseription in subsection 2a as confidential, enter a generic description ofthat category, Read the 

use Instru~"tions Manual for examples of generic use descriptions. 

description Sulfide Mineral Processing Reagent 

D Mark (X) this box ifyou attach a continuation sheet. 

3. Hazard Information Include in the notice a copy ofreasonable facsimile of any hazard warning statement, label, material safety data sheet, or other Binding 

information which will be provided to any person who is reasonably likely to be exposed to this substance regarding protective equipment or practices Option 

fOf the safe handing, transport, use, or disposal ofthe new substance. List in part III hazard information you include. Mark (x) 

Mark (X) this box ifyou attach hazard information. See Attachments 1 and 2: MSDS and Label. 

EPA FORM 7710-25 (Rev. 5-95) Page 7 
Part ll-­

Complete section A for each type of manufacture, processing, or use operation involving the new chemical substance at industrial sites you 

you 

control. Importers do not have to complete this section for operations outside the US.; however, you may still have reporting requirements if 

there are further industrial . or use . after' You must describe these . See instructions manual 

I. 

of the site at "Which the will occur. 

Name 

This substance will be imported. See below 

Site address (number and street) 

City, County, State, ZIP code 

If the same operation will occur at more than one slte, enter the number of SIteS. Identify the 

additional sites on a continuation sheet, and ifany of the sites have significantly different 

production rates or operations, include all the information requested in this section for those 

sites as attachments. 

1. Batch 

2. Continuous 

Maximum kgtbatch (100% new chemical Hourslbatch 

substance) 

d. Process description Mark (X) to indicate your willingness to have your process description binding. 

Use 

Batches/year 

Batches/year 

(1) Diagram the major unit operation steps and chemical conversions. Include interim storage and transport containers (specify- e.g. 5 gallon pails, 55 gallon 

drum, rail car, tank truck, etc.). 

(2) Provide the identity, the approximate weight (by kg/day or kg/batch on a 100% new chemical substance basis), and entry point of aU starting materials and 

feedstocks (including reactants, solvents, catalysts, etc.), and of all products, recycle streams, and wastes. Include cleaning chemicals (note frequency if not 

used daily or per batch.). 

(3) Identify by number the points of release, including small or intermittent releases, to the environment ofthe new chemical substance. 

The information requested on this page does not apply for this substance because it is imported. 

None is manufactured in the U.S. by the submitter. The product will be imported either to a 

warehouse or directly to the customer mine site. The manufacturer's quality control data will be used 

and reported routinely 

D Mark (X) this box if you attach a continuation sheet. 

EP A FORM 7710-25 (Rev. 5-95) PageS 
I 

Part TI-- HUMAN EXPOSURE AND ENVIRONMENTAL RELEASE -- Continued 

Section A -- INDUSTRIAL SITES CONTROLLED BY THE SUBMITTER - Continued 

2. Occupational Exposure You must make separate confidentiality claims for the description of worker activity, physical form ofthe new chemical substance, 

number of works exposed, and duration of activity. Mark (X) the "Confidential" box next to any item you claim as confidential. 

(I) •• Describe the activities (i.e. bag dumping, tote filling, unloading drums, sampling, cleaning, etc.) in which workers may be exposed to the substance. 

(2) •• Mark (X) this column if entry in column (I) is confidential business information (CBI). 

(3)·· Describe any protective equipment and engineering controls used to protect workers. 

(4) and (6) •• Inaicate your willingness to have the information provided in column (3) or (5) binding. 

(5) •• Indicate the physical formes) ofthe new chemical substance (e.g., solid: crystal, granule, powder, or dust) and % new chemical substance (if part ofa mixture) 

at the time of exposure. 

(7)·· Mark (X) this column if entry in column (5) is confidential business information (CHI). 

(8) •• Estimate the maximum number of workers involved in each activity for all sites combined. 

(9) •• Mark (X) this column if entry in column (8) is confidential business information (CBI). 

(10) and (II)·· Estimate the maximum duration ofthe activity for any worker in hours per day and days per year. 

(12) .. Mark' '~"iN 10) and (I 1) are confidential business information CBl). 

Worker activity Protective Equipment! Binding Physical forms(s) Binding eBI #of eBI Maximu eBI 

m 

(i.e., bag dumping, filling drums) Engineering Controls Option and % new Option Worker Hrs/day Daysfyr Mark (x) substance Mark (x) S 

(1) (3) (4) (5) (6) (7) Expose (9) (10) (1) (12) 

d 

(8) 

No exposure is 

expected in import and 

transshipment r procedures. Refer to 

Attachment 5: Risk 

Evaluation. 

I:8J Mark (X) this box if you attach a continuation sheet. See Attachment 5. 

3. Envirolll1lental Release and Disposal •• You must make separate confidentiality claims for the release number and the amount ofthe new chemical substance 

released and other release and disposal information. Mark (X) the "Confidential" box next to each item you claim as confidential. 

(1) .• Enter the number of each release point identified in the process description, part II, section A, subsection Id(3). 

(2)·· Estimate the amount ofthe new substance released (a) directly to the environment or (b) into control technology (in kg/day or kg/batch). 

(3) .. Mark (X) this column if entries in columns (1) and (2) are confidential business information (CHI). 

(4) .• Identify the media (stack air, fugitive air (optional·see Instruction Manual), surface water, on·site or off·site land or incineration, POTW, or other (specifY)) to 

which the new substance will be released from that release point. 

(5) .. a. Describe control technology, if any, and control efficiency that will be used to limit the release of the new substance to the environment. For releases 

disposed of on land, characterize the disposal method and state whether it is approved for disposal ofRCRA hazardous waste. On a continuation sheet, for 

each site describe any additional disposal methods that will be used and whether the waste is subject to secondary or tertiary on·site treatment. b. Estimate 

the amount released to the environment after control technology (in kg/day). 

(6) •• Mark (X) this column if entries in columns (4) and (5) are confidential business information (CBI). 

(7) •• IdentifY the destination(s) of releases to water. Please supply NPDES (National Pollutant Discharge Elimination System) numbers for direct discharges or 

NPDES numbers ofthe POTW (Publici Owned Treatment Works). Mark (X) ifthe POTW name or NPDES # is confidential business information (CBI). 

Release Amount ofnew substance CHI Media of Control technology and efficiency (you may wish to optionally attach efficiency data) CBI 

Number released release 

(I) (2a e.g.naekair Binding 

(3) (4) (5a) Mark (X) (5b) (6) 

No release is expected in import 

procedures, refer to Attachment 

5: Risk Evaluation. 

(7) Mark (X) the o POTW provide name(s) below: CHI o Navigable o Other· SpecifY provide NPDES # CBI '--­ destination(s) of waterway 

releases to water. NA NA orno NA 

releases 

Mark (X) this box ifyou attach a continuation sheet. See Attachment 5 

EPA FORM 7710·25 (Rev. 5·95) Page 9 
Part 11-- HUMAN EXPOSURE AND ENVIRONMENTAL RELEASE -- Continued 

Section B --INDUSTRIAL SITES CONTROLLED BY OTHERS 

Complete section B for typical processing or use operations involving the new chemical substance at sites you do not control. Importers do not have to complete this 

section for operations outside the U.S.; however, you must report any processing or use activities after import. See the Instructions Manual. Complete a separate 

section B for each type ofprocessing. or use operation involving the new chemical substance. If the same operation is perfonned at more than one site describe the 

ty ical 0 eration common to these sites. Identi additional sites on a continuation sheet. 

1. Operation Description •• To claim information in this section as confidential, circle or bracket the specific infonnation that you claim as confidential. 

(l) Diagram the major unit operation steps and chemical conversions, including interim storage and transport containers (specifY - e.g. 5 gallon pails, 55 gallon 

drums, rail cars, tank trucks, etc). On the diagram, identifY by letter and briefly describe each worker activity. (2) -- Provide the identity, the approximate weight 

(by kg/day or kg/batch, on an 100% new chemical substance basis), and entry point of all feedstocks (including reactants, solvents and catalysts, etc) and all 

products, recycle streams, and wastes. Include cleaning chemicals (note frequency if not used daily or per batch). (3) -- Identify by number the points ofrei ease, 

including small or intermittent releases, to the environment ofthe new chemical substance. (4) Please enter the # of sites (remember to identify the locations of 

these sites on a continuation sheet): 

# of sites 

t8J Mark (X) this box ifyou attach a continuation sheet. See a e lOA. 3-5 sites (by year 3). 

2. Worker ExposurelEnvironmental. Release 

(I) From the diagram above, provide the letter for each worker activity. Complete 2-8 for each worker activity described 

(2) .. Estimate the number of workers exposed for all sites combined. 

(4) -- Estimate the typical duration of exposure per worker in (a) hours per day and (b) days per year. 

(6) -- Describe physical form of exposure and % new chemical substance (if in mixture), and any protective equipment and engineering controls, if any, used to 

protect workers. 

(7) -- Estimate the percent ofthe new substance as fonnulated when packaged or used as a fmal product. 

(9) _. From the process diagram above, enter the number of each release point. Complete 9-13 for each release point identified. 

(10) -- Estimate the amount ofthe new substance released (a) directly to the environment or (b) into control technology to the environment (in kg/day or kgibatch). 

(12) .- Describe media ofrelease i.e. stack air, fugitive air (optional-see Instructions Manual), surface water, on-site or off-site land or incineration, POTW, or other 

(specifY) and control technology, if any. that will be used to limit the release of the new substance to the environment. 

(14) -- Identify bypro ducts which may result from the operation. 

(3), (5), (8), 11), (13) and (15) -­ Mark (X) this column if any of the proceeding entries are confidential business information (CBI). 

Letter #of CBI Duration CBI Protective Equip. / %in eBI Release Amount of CDI Media of Release em 

of Workers of Engineering Controls! Form- Number New & Control 

Act- Exposed Exposure Physical Fonn and % ulation Substance Technology 

ivity new substance Released 

(I) (2) (3) (4a) (4b) (5) (6) (1) (8) (9) (lOa) (lOb) (11) (12) (13) 

X X 

X X 

X 

W ~ I (15) 

t8J Mark (X) this box if you attach a continuation sheet, see page lOA 

EPA FORM 7710-25 (Rev. 5-95) Page 10 
OPTIONAL POLLUTION PREVENTION INFORMATION 

To claim information in this section as confidential circle or bracket the specific information that you claim as confidential. 

In this section you may provide information not reported elsewhere in this form regarding your efforts to reduce 

or minimize potential risks associated with activities surrounding manufacturing, processing, use and disposal 

ofthe PMN substance. Please include new information pertinent to pollution prevention, including source 

reduction, recycling activities and safer processes or products available due to the new chemical substance. 

Source reduction includes the reduction in the amount or toxicity of chemical wastes by technological 

modification, process and procedure modification, product reformulation, raw materials substitution, andlor 

inventory control. Recycling refers to the reclamation ofuseful chemical components from wastes that would 

otherwise be treated or released as air emissions or water discharges, or land disposal. Descriptions of pollution 

prevention, source reduction and recycling should emphasize potential risk reduction subsequent to compliance 

with existing regulatory requirements and can be either quantitative or qualitative. The EPA is interested in the 

information to assess overall net reductions in toxicity or environmental releases and exposures, not the shifting 

of risks to other environmental media or non-environmental areas (e.g., occupational or consumer exposure). In 

addition, information on the relative cost or performance characteristics of the PMN substance to potential 

alternatives may be provided. 

All information provided in this section will be taken into consideration during the review of this 

substance. See Instructions Manual and Pollution Prevention Guidance manual for guidance and 

examples. 

Describe the expected net benefits, such as (I) an overall reduction in risk to human health or the environment; (2) a reduction in the 

volume manufactured; (3) a reduction in the generation of waste materials through recycling, source reduction or other means; (4) a 

reduction in potential toxicity or human exposure and/or environmental release; (5) an increase in product performance, a decrease in 

the cost of production and/or improved operation efficiency of the new chemical substance in comparison to existing chemical 

substances used in similar application; or (6) the extent to which the new chemical substance may be a substitute for an existing 

substance that poses a greater overall risk to human health or the environment. 

This substance will be imported into the US, thereby eliminating possible releases associated with 

manufacturing. However, CYTEC is committed to protection of health and the environment under all 

statutes and regulations for those products that are manufactured in the US. This includes our 

commitment to CMA's Responsible Care program (including Pollution Prevention and Product 

Stewardship Codes). 

D Mark (X) this box if you attach a continuation sheet. 

EPA FORM 7710-25 (Rev. 5-95) Page II 
Part III -- LIST OF ATTACHMENTS 

Attach continuation sheets for sections ofthe form and test data and other data (including physicaVchemical properties and 

structure/activity information), and optional information after this page. Clearly identify the attachment and the section of the form to 

which it relates, if appropriate. Number consecutively the pages of the attachments. In the column below, enter the inclusive page 

numbers of each attachment. 

Mark (X) the "Confidential" box next to any attachment name you claim as confidential. Read the Instructions Manual for guidance on 

how to claim any information in an attachment as confidential. You must include with the sanitized copy of the notice form a sanitized 

version of any attachment in which you claim information as confidential. 

Attachment name 

Attachment 1: Material Safety Data Sheet (MSDS) 

Attachment 2: Label 

Attachment 3: CAS Inventory Expert Service Report 

Attachment 4: IR Spectrum 

Attachment 5: Tox Summary 

Attachment 6: Risk Evaluation 

Attachment 7: Process Description 

Attachment 8: MSDS for Reactants 

Attachment 9: Final Toxicological Testing Reports 

Attachment 

page number(s) 

14-21 

22-23 

24-27 

28 

29-33 

34-35 

36 

37-55 

56-205 

Confidential 

X 

X 

X 

X 

X 

I 

I 

I 

I 

I 

D Mark (X) this box ifyou attach a continuation sheet. Enter the attachment name and number. 

EPA FORM 7710-25 (Rev. 5-95) Page 12 
PHYSICAL AND CHEMICAL PROPERTIES WORKSHEET 

To assist EPA's review ofphysical and chemical properties data, please complete the following worksheet for data you provide and 

include it in the notice. Identify the property measured, the page ofthe notice on which the property appears, the value ofthe property, 

the units in which the property is measured (as necessary), and whether or not the property is claimed as confidential. The physical 

state ofthe neat substance should be provided. These measured properties should be for the neat (100% pure) chemical substance. 

Properties that are measured for mixtures or formulations should be so noted (% PMN substance in -.l. You are not required to 

submit this worksheet; however, EPA strongly recommends that you do so, as it will simplify review and ensure that confidential 

-information is properly protected. You should submit this worksheet as a supplement to your submission oftest data. 'This worksheet 

is not a substitute for submission oftest data. 

Property Page Value [Measured 0 Conndential 

(a) 

Physical state of neat substance 

Vapor pressure 

@ Temperature °C 

Density/relative density @25°C 

Solubility 

@ Temperature °C 

Solvent 

Solubility in water @ Temperature °C 

Melting temperature 

Boiling / sublimation temperature@ torr pressure 

Spectra IR., NMR 

Dissociation constant 

Particle size distribution 

Octanoll water partition coefficient 

Henry's Law constant 

IVolitalization from water 

IVolitalization from soil 

rPh @ concentration 10% in deionized water 

Flammability (Flash point) 

Explodability 

Adsorption I coefficient 

Other - Specify 

number 

(c) 

(s) X (1) (g) 

Torr 

X 

0.991 glcm3 

X 

Ivery soluble in most polar 

solvents e. g. acetone, alcohols 

acetonitrile etc. 

gIL 

X 

insoluble gIL 

°C 

°C 

X 

3.45 

X 105 OF 

Estimate Mark (X) 

(M or E) (d) 

M 

= 

M 

M 

ATTACHMENT 


PAGE 13 


IYTEI: 

h,tclmology ahaQ,/ ofits limam 

MSDS: 0014173 

Date: 02/04/2003 

MATERIAL SAFETY DATA SHEET 

1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATION 

Product Name: AERO® 5715 Promoter 

Synonyms: None 

Chemical Family: Modified Thionocarbamate 

Molecular Formula: Mixture 

Molecular Weight: Mixture 

CYTEC INDUSTRIES INC .. FIVE GARRET MOUNTAIN PLAZA, WEST PATERSON. NEW JERSEY 07424, USA 


For Product Information call 1-800/652-6013. Outside the USA and Canada call 1-973/357-3193. 


EMERGENCY PHONE: For emergency involving spill. leak. fire. exposure or accident call CHEMTREC: '!-8001424­

9300. Outside the USA and Canada call 1-703/527-3887. 


® indicates trademark registered in the U.S. Outside the U.S., mark may be registered. pending or a trademark. Mark 


is or may be used under license. 


---------------_._-----­

2. COMPOSITION/INFORMATION ON INGREDIENTS 

OSHA REGULATED COMPONENTS 

Component I CAS No. 

Isobutanol 

78-83-1 

% 

15 - 20 

(w/w) OSHA (PEL): 

100 ppm 

ACGIH (TLV) 

50 ppm 

Carcinogen 

Quinoline 

91-22-5 

1 - 2' Not Established Not Established 

Modified thionocarbamate Proprietary No! Established Not Established 

3. HAZARDS IDENTIFICATION 


EMERGENCY OVERVIEW 

APPEARANCE AND ODOR: 

Color: 

Appearance: 

Odor: 

brown to amber 

clear liquid 

alcohol/aromatic 

STATEMENTS OF HAZARD: 
AERO® 5715 Promoter 	 MSDS: 0014173 Date: 02104/2003 Page 2 of8 

WARNING! 	 COMBUSTIBLE LIQUID AND VAPOR 


MAY CAUSE ALLERGIC SKIN REACTION 


MAY CAUSE EYE IRRITATION 


CHRONIC HAZARD WARNING: 

CONTAINS MATERIAL WHICH CAUSED GENETIC CHANGES IN LABORATORY ANIMAL TESTS 

Risk of effects depends on duration and level of exposure 

POTENTIAL HEALTH EFFECTS 

EFFECTS OF OVEREXPOSURE: 

The acute oral (rat) LD50 value is estimated to be greater than 500 mg/kg and less than 1,000 mg/kg. The 

dermal (rabbit) LDSO value is greater than 2.000 mg/kg. 

Direct contact with this material may cause mild eye and minimal skin irritation. Repeated or prolonged dermal 

contact may cause allergic skin reactions. Overexposure to vapors may cause irritation of the respiratory tract 

and eyes and may cause central nervous system effects. Refer to Section 11 for toxicology information on the 

regulated components of this product. 

4. FIRST AID MEASURES 

Ingestion: 


If swallowed, call a physician immediately. Only induce vomiting at the instruction of a physician. Never give anything 


by mouth to an unconscious person. 


Skin Cm,tact: 


Wash immediately with plenty of water and soap. Remove contaminated clothing and shoes' without delay. Obtain 


medical attention. Do net reuse contaminated clothing without laundering. Destroy or thoroughly clean shoes before 


reuse. 


Eye Contact: 


Rinse immediately with plenty of water for at least 15 minutes. 


Inhalation: 


Remove to fresh air. If breathing is difficult, give oxygen. Obtain medical advice if there are persistant symptoms. 


5. FIRE-FIGHTING MEASURES 

Extinguishing Media: 


Use water spray. alcohol foam, carbon dioxide or dry chemical to extinguish fires. Water stream may be ineffective. 


Protective Equipment: 


Firefighters, and others exposed, wear self-contained breathing apparatus. Wear full firefighting protective clothing. 


See Section 8 (Exposure Controls/Personal Protection). Use approved air-:;upplied full face respirator. 


Special Hazards: 


Keep containers cool by spraying with water if exposed to fire. 


6. ACCIDENTAL RELEASE MEASURES 

Personal Precautions: 


Where exposure level is known, wear approved respirator suitable for level of exposure. Where exposure level is not 


known, wear approved, positive pressure, self-contained respirator. In addition to the protective clothing/equipment in 


Section 8 (Exposure Controls/Personal Protection), wear impermeable boots. 

AERO® 5715 Promoter MSDS: 0014173 Date: 02104/2003 Page 3 of 8 

Methods For Cleaning Up: 


Cover spills with some inert absorbent material; sweep up and place in a waste disposal container. Flush spill area 


with wate·r. Remove sources of ignition. 


Environmental Precautions: 


Use appropriate containment to avoid environmental contamination. 


7. HANDLING AND STORAGE 

HANDLING 

Precautionary Measures: Keep away from heat and flame. Avoid prolonged or repeated contact with skin. Avoid 

contact with eyes. Wash thoroughly after handling. 

Handling Statements: None 

STORAGE 

Areas containing this material should have fire safe practices and electrical equipment in accordance with applicable 

regualtions and/or guidelines. Standards are primarily based on the material's flashpoint, but may also take into 

account properties such as miscibility with water or toxicity. All local and national regulations should be followed. 

In the Americas, National Fire Protection Association (NFPA) 30: Flammable and Combustible Liquids Code, is a 

widely used standard. NFPA 30 establishes storage conditions for the following classes of materials: Class I 

Flammable Liquids, Flashpoint <37.SC Class II Combustible Liquids, 37.SC < Flashpoint <60C Class Ilia Combustible 

Liquids, 60 C < Flashpoint < 93C Class Illb Combustible Liquids, Flashpoint > 93 C 

Storage Temperature: Room temperature 

Reason: Integrity 

8. EXPOSURE CONTROLS/PERSONAL PROTECTION 

Engineering Measures: 


Where this material is not used in a closed system, good enclosure and local exhaust ventilation should be provided to 


control exposure. 


Respiratory Protection: 


Where exposures are below the established exposure limit. no respiratory protection is required. Where exposures 


exceed the established exposure limit. use respiratory protection recommended for the material and level of exposure. 


Eye Protection: 


Wear eye/face protection such as chemical splash proof goggles or face shield. Eyewash equipment and safety 


shower should be provided in areas of potential exposure. 


Skin Protection: 


Avoid skin contact. Wear impermeable gloves and suitable protective clothing. 


Additional Advice: 


Food, beverages, and tobacco products should not be carried, stored, or consumed where this material is in use. 


Before eating, drinking. or smoking. wash face and hands thoroughly with soap and water. It is recommended that a 


shower be taken after completion of workshift especially if significant contact has occurred. Work clothing should then 


be laundered prior to reuse. Street clothing should be stored separately from work clothing and protective equipment 


Work clothing and shoes should not be taken home. 


9. PHYSICAL AND CHEMICAL PROPERTIES 

Color: brown to amber 

Appearance: clear liquid 
AERO® 5715 Promoter MSDS: 0014173 Date: 02104/2003 Page 4 of 8 

Odor: 


Boiling Point: 


Melting Point: 


Vapor Pressure: 


Specific Gravity: 


Vapor Density: 


Percent Volatile (By Wt.): 


pH: 


Saturation In Air (% By Vo!.): 


Evaporation Rate: 


Solubility In Water: 


Volatile Organic Content: 


Flash Point: 


Flammable Limits (% By Vol): 


Autoignition Temperature: 


Decomposition Temperature: 


Partition coefficient (n­


octanollwater): 


Odor -rhreshold: 


alcohol/aromatic 

Not available 

Not available 

Not available 

0.991 

Not available 

Not available 

3.45 

Not available 

(value for isobutanol) 

Dispersible 

Not available 

40.6 °C 105 OF Pensky-Martens Closed Cup 

Not available 

Not available 

Not available 

Not available 

See Section 2 for exposure limits. 

10. STABILITY AND REACTIVITY 


Stability: 


Conditions To Avoid: 


Polymerization: 


Materials To Avoid: 


Hazardous Decomposition 

Products: 

Stable 

Avoid contact with oxidizing agents, bases or amines. 

Will not occur 

Alkali or amines, oxidizing agents. 

carbon dioxide 

carbon monoxide 

oxides of nitrogen 

oxides of sulfur (includes sulfur di and tri oxides) 

11. TOXICOLOGICAL INFORMATION 

Toxicological information for the product is found under Section 3. HAZARDS IDENTIFICATION. 

Toxicological information on the regulated components of this product is as follows: 

Modified thionocarbamate toxicological properties have not been fully investigated. This material was negative in the 

Ames Salmonella Assay and was negative for Chromosome Aberrations, however, it was positive in the Mouse 

Micronucleus Assay. Based on a structurally similar material, the estimated acute oral (rat) LD50 and acute dermal 

(rabbit) LD50 values are >1.700 mg/kg and >2.000 mg/kg, respectively. Direct contact with this material may cause 

mild eye and moderate skin. Repeated or prolonged dermal contact with modified thionocarbamate may cause 

allergic skin reactions. 

Isobutanol has acute oral (rat) and dermal (rabbit) LD50 values of 2.46 g/kg and 3.4 g/kg, respectively. The LC50 

(rat) following a 4-hour inhalation exposure is >8000 ppm (24.24 mg/L). Acute overexposure to isobutanol vapor can 

cause irritation to the eyes (severe), skin (moderate). and mucous membranes, as well as, central nervous system 

depression. Direct contact with isobutanol may cause severe eye and mild to moderate skin irritation. 
AERO® 5715 Promoter MSDS: 0014173 Dale: 02104/2003 Page 5 of 8 

Quinoline (CAS# 91-22-5) has acute oral (rat) and dermal (rabbit) LD50 values of 331 mg/kg and 591 mg/kg. Direct 

c9ntact ~ith this material may cause moderate-severe eye irritation and moderate skin irritation. The vapor can irritate 

the eyes, nose, throat and respiratory tract. NTP reports that this material has produced both positive and negative 

results in chromosome aberration assays, was negative in the mouse lymphoma assay, and positive in the salmonella 

(Ames) assay for mutagenicity. This material was a liver tumorigen in sub-chronic mouse and rat studies. Quinoline 

has been reported to be toxic to the retina or optic nerve, affecting vision. 

California Proposition 65 Warning (applicable in California only) - This product contains (a) chemical(s) known to the 

State of California to cause cancer. 

12. ECOLOGICAL INFORMATION 

Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. 


This material is not readily biodegradable. 


ALGAE TEST RESULTS 


Test: Growth Inhibition (OECD 201) 


Duration: 72 hr 


Species: Green Algae (Selenastrum capricornutum) 


>1 - 10 mg/l EbC50 Information based on a structurally similar material. 


>10 - 100 mg/l ErCSO Information based on a structurally similar material. 


FISH TEST RESULTS 


Test: Acute toxicity. freshwater (OECD 203) 


Duration: 96 hr. 


Species: Rainbow Trout (Oncorhyncus mykiss) 


7.1 mg/l LCSO 

INVERTEBRATE TEST RESULTS 

Test: Acute Immobilization (OECD 202) 

Duration: 48 hr 

Species: Water Flea (Daphnia magna) 

7.7 mg/l ECSO 

DEGRADATION 

Test: C02 Evolution: Modified Sturm (OECD 301 B) 

Duration: 28 day Procedure: Ready biodegradability 

17.S % 
AERO® 5715 Promoter MSDS: 0014173 Date: 02104/2003 Page 6 of 8 

13. DISPOSAL CONSIDERATIONS 

The information on RCRA waste classification and disposal methodology provided below applies only to the Cytec 

product, as supplied. If the material has been altered or contaminated, or it has exceeded its recommended shelf life, 

the guidance may be inapplicable. Hazardous waste classification under federal regulations (40 CFR Part 261 et seq) 

is dependent upon whether a material is a RCRA 'listed hazardous waste'or has any of the four RCRA 'hazardous 

waste characteristics.' Refer to 40 CFR Part 261.33 to determine if a given material to be disposed of is a RCRA 'listed 

hazardous waste'; information contained in Section 15 of this MSDS is not intended to indicate if the product is a 

'listed hazardous waste:RCRA Hazardous Waste Characteristics: There are four characteristics defined in 40 CFR 

Section 261.21-61.24: Ignitability, Corrosivity, Reactivity, and Toxicity. To determine Ignitability, see Section 9 of this 

MSDS {flash point}. For Corrosivity, see Sections 9 and 14 (pH and DOT corrosivity). For Reactivity, see Section 10 

(incompatible materials). For Toxicity, see Section 2 (composition). Federal regulations are subject to change. State 

and local requirements, which may differ from or be more stringent than the federal regulations, may also apply to the 

classification of the material if it is to be disposed. Cytec encourages the recycle, recovery and reuse of materials, 

where permitted, as an alternate to disposal as a waste. Cytec recommends that organic materials classified as 

RCRA hazardous wastes be disposed of by thermal treatment or incineration at EPA approved facilities. Cytec has 

provided the foregoing for information only; the person generating the waste is responsible for determining the waste 

classification and disposal method. 

14. TRANSPORT INFORMATION 

This section provides basic shipping classification information. Refer to appropriate transportation regulations for 

specific requirements. 

US DOT 

Proper Shipping Name: Flammable liquid, n.o.s. 

Hazard Class: 3 

Packing Group: III 

UNIID Number: UN1993 

Transport Label Required: Flammable Liquid 

Marine Pollutant 

Technical Name (N.O.S.): Contains isobutanol and modified thionocarbamate 

Hazardous Substances: 

Component / CAS No. Reportable Quantity of Product (lbs) 

Isobutanol 25000 

TRANSPORT CANADA 

Proper Shipping Name: Flammable liquid, n.o.s. 

Hazard Class: 3 

Packing Group: III 

UN Number: 1993 

Transport Label Required: Flammable Liquid 

Marine Pollutant 

Technical Name {N.O.S.}: Contains isobutanol and modified thionocarbamate 

ICAOIIATA 

Proper Shipping Name: Flammable liquid, n.o.s. 

Hazard Class: 3 

Packing Group: III 

UN Number: 1993 

Transport Label Required: Flammable Liquid 

Marine Pollutant 

Packing Instructions/Maximum Net Quantity Per Package: 

Passenger Aircraft: 309; 60 L 

Cargo Ajrcraft: 310; 220 L 
AERO® 5715 Promoter MSDS: 0014173 Date: 02104/2003 Page 7 of 8 

Technical Name (N.O.S.): Contains isobutanol and modified thionocarbamate 

IMO 

Proper Shipping Name: Flammable liquid, n.o.s. 

Hazard Class: 3 

UN Number: 1993 

Packing Group: III 

Transport Label Required: Flammable Liquid 

Marine Pollutant 

Technical Name (N.O.S.): Contains isobutanol and modified thionocarbamate 

15. REGULATORY INFORMATION 

INVENTORY INFORMATION 

United States (USA): The chemical, physical, and toxicological properties of this material have not been fully 

investigated. Its handling or use may be hazardous. Exercise Due Care. Since this material may contain 

chemicals not included in the Toxic Substances Control Act Inventory, it must be used under the supervision of 

technically qualified individuals. Materials not included in the Toxic Substance Control Act Inventory must not be 

used for commercial purposes. 

Canada: This product contains components not on the Domestic Substances List. 

European Union (EU): Product is not included in the European Inventory of Existing Chemical Substances 

(EINECS). Product can be supplied in quantities less than 10 kg/year according to Council Directive 67/548/EEC 

and its amendments. 

OTHER ENVIRONMENTAL INFORMATION 

The following components of this product may be subject to reporting requirements pursuant to Section 313 of 

CERCLA (40 CFR 372), Section 12(b) of TSCA, or may be subject to release reporting requirements (40 CFR 307, 40 

CFR 311, etc.) See Section 13 for information on waste classification and waste disposal of this product. 

Component I CAS No. TPQ(lbs) RQ(lbs) S313 TSCA12B 

Isobutanol NONE 5000 No No 

78-83-1 

Quinoline NONE 5000 Yes No 

91-22-5 

PRODUCT HAZARD CLASSIFICATION UNDER SECTION 311 OF SARA 

• Acute 

• Chronic 

• Fire 

16. OTHER INFORMATION 

NFPA Hazard Rating (National Fire Protection Association) 

Health: 2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury. 

Fire: 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before 

ignition can occur. 

Reactivity: 0 - Materials that in themselves are normally stable, even under fire exposure conditions. 
AERO® 5715 Promoter MSDS: 0014173 Date: 02104/2003 Page 8 of 8 

Reasons For Issue: New Product 

Randy Deskin, Ph.D., DABT +1-973-357-3100 

This information is given without any warranty or representation. We do not assume any legal responsibility for same, nor do we give permission, 

inducement, or recommendation to practice any patented invention without a license. It is offered solely for your consideration, investigation, and 

verification. Before using any product, read its label. 

US Label Prototype # LUS 0014173 02104/2003 AERO® 5715 Promoter Page 1 of2 

rYTEI: 

1;'dmology ahead ofits limam 

AERO® 5715 Promoter 

Sulfide mineral collector 

Precautionary Warning Statement: 

WARNING! 

COMBUSTIBLE LIQUID AND VAPOR 

MAY CAUSE ALLERGIC SKIN REACTION 

MAY CAUSE EYE IRRITATION 

ONTAtNSMATERIAL WHICH CAUSED GENETIC CHANGES IN LABORATORY ANIMAL TESTS 

isk of effects de ends on duration and level of ex osure 

Keep away from heat and flame. 


Avoid prolonged or repeated contact with skin. 


Avoid contact with eyes. 


Wash thoroughly after handling. 


FIRST AID 

Eye Contact: Rinse immediately with plenty of water for at least 15 minutes. 

Skin Contact: Wash immediately with plenty of water and soap. Remove contaminated clothing and shoes without 

delay. Obtain medical attention. Do not reuse contaminated clothing without laundering. Destroy or thoroughly clean 

shoes before reuse. 

Inhalation: Remove to fresh air. If breathing is difficult. give oxygen. Obtain medical advice if there are persistant 

symptoms. 

Ingestion: If swallowed. call a physician immediately. Only induce vomiting at the instruction of a physician. Never 

give anything by mouth to an unconscious person. 

Notice: FOR RESEARCH AND DEVELOPMENT PURPOSES ONLY 

The chemical. physical and toxicological properties of this material have not been fully investigated. Its handling or use 

may be hazardous. Exercise due care. Since this material may contain chemicals not included in the Toxic 

Substances Control Act Inventory. it must be used under the supervision of technically qualified individuals. Materials 

not included in the Toxic Substances Control Act Inventory must not be used for commercial purposes. 

® indicates trademark registered in the U.S. Outside the U.S .• mark may be registered, pending or a trademark. Mark 

is or may be used under license. 

Right-to-know data for Component I CAS No. 

Before handling this material, read Cytec Material Safety Data Sheet # 0014173 for more detailed safety, health and 

environmental data. 

The following components of this product are listed in accordance with right-to-know laws: 

Component I CAS No. 

Isobutanol 78-83-1 

Quinoline 91-22-5 
US Label Prototype # LUS 0014173 02/04/2003 AERO® 5715 Promoter Page 2 of 2 

Modified thionocarbamate 

Standard Packaging Statements: 

Drums: 

ATTENTION - Container headspace may contain hazardous gas or vapor. Open container with care, using 

adequate ventilation and avoiding ignition sources. Do not use air pressure or apply heat with open flame to 

remove contents of container. After emptied, container may retain solid, liquid, and/or vapor residues. Continue 

to observe all precautions, if any, on label. Do not cut, puncture, torch, or weld on or near emptied container. Do 

not use for other purposes. 

Bags: 

ATTENTION - After emptying, bag may retain solid, liquid, and/or vapor residues. Continue to observe all 

precautions, if any, on label. Do not cut, puncture, torch, or weld on or near emptied container. Do not use for 

other purposes. 

Tank car/truck (bulk): 

ATTENTION - Container headspace may contain hazardous gas or vapor. Open container with care, using 

adequate ventilation and avoiding ignition sources. DO NOT REMOVE TAG UNTIL TANK IS CLEANED. 

CYTEC INDUSTRIES INC. - WEST PATERSON, NJ 07424 USA Emergency Phone - In Canada: 905/356-8310; In 

USA: 1-800/424-9300 or 703/527-3887 

TOXICOLOGY SUMMARY 


Toxicology test results include data for the P:MN substance (98+%) as well as data for a 

final fonnulated product, which contains the P:MN substance at (-70%). It should be 

noted that the P:MN substance will be supplied to customers in product fonnulations only, 

and not as a "pure" chemical. 

Test Material- PMN Substance (98+%) 

Ames Test - Salmonella typhimurium strains TA1535, TA1537, TA98, TAlOO and E. 

coli strain WP2uvrA- were treated with solutions of the test material using the Ames 

plate incorporation method at up to seven dose levels, in triplicate, both with and without 

the addition of a rat liver homogenate metabolizing system. 

No significant increases in the frequency of revertant colonies were recorded for any of 

the bacterial strains, with any dose of the test material, either with or without metabolic 

activation. 

Based on these results, the test material was considered to be non-mutagenic. 

In Vitro Chromosome Aberrations Test in Human Lymphocytes - Duplicate cultures 

of human lymphocytes. treated with the test material, were evaluated for chromosome 

aberrations at up to three dose levels, together with vehicle and positive controls. Four 

treatment conditions were used in this study, i.e. in Experiment 1,4 hours in the presence 

of an induced rat liver homogenate metabolizing system (S9), at a 1 % final concentration 

with cell harvest after a 20-hour expression period and a 4-hour exposure in the absence 

of metabolic activation (S9) with a 20-hour expression period. In Experiment 2, the 4­

hour exposure with addition of S9 was repeated (using a 2% final S9 concentration), 

while in the absence of metabolic activation the exposure time was increased to 24 hours. 

All vehicle (solvent) controls gave frequencies of cells with aberrations within the range 

expected for nonnal human lymphocytes. 

All positive control treatments gave statistically significant increases in the frequency of 

cells with aberrations indicating the satisfactory perfonnance of the test and the activity 

of the metabo1izing system. 

The test material did not induce any statistically significant increases in the frequency of 

cells with aberrations, in either of the two separate experiments, using a dose range that 

included a dose level that induced approximately 50% mitotic inhibition. 

Based on these results, the test material was shown to be non-clastogenic to human 

lymphocytes. 

Initial In Vivo Mouse Micronucleus Test - A range-finding study was perfonned to 

find suitable does levels of the test material and to investigate to see if there was a 

marked difference in toxic responses between the sexes. There was no marked difference 
in test material toxicity between the sexes; therefore the main study was performed using 

only male mice. The micronucleus study was conducted using the oral route in groups of 

seven mice (males) at the maximum tolerated dose (MTD) 200 mglkg with 100 and 50 

mg/kg as the two lower dose levels. Animals were sacrificed 24 or 48 hours later, the 

bone marrow extracted and smear preparations made and stained. Polychromatic (PCE) 

and normochromatic (NCE) erythrocytes were scored for the presence of micronuclei. 

Further groups of mice were given a single oral dose of arachis oil (7 mice) or dosed 

orally with cyclophosphamide (5 mice), to serve as vehicle and positive controls, 

respectively. Vehicle control animals were sacrificed 24 or 48 hours later, and positive 

control animals were sacrificed after 24 hours. 

A statistically significant decrease in the PCElNCE ratio was observed in the 48-hour test 

material dose group when compared to the concurrent control group, indicating a 

cytotoxic response in the bone marrow. This was accompanied by the observation of 

premature deaths and clinical signs and was taken to indicate that systemic absorption 

and exposure to the target tissue had occurred. 

Increases in the incidence of micronucleated polychromatic erythrocytes (MNPCE) were 

observed in animals dosed with the test material when compared to the concurrent 

vehicle controls groups. However, the increases in the incidence of MNPCEs in both the 

24 and 48-hour 200 mg/kg test material groups were not statistically significant. In both 

cases the increase was greater than two-fold over the concurrent control and some 

individual animals had frequencies of MNPCEs that were far in excess of the historical 

maxima. 

The positive control material produced a marked increase in the frequency of 

micronucleated polychromatic erythrocytes. 

Based on these results, the test material was considered to be weakly genotoxic at a 

dose level that was close to the toxic limit. 

Second In Vivo Mouse Micronucleus Assay - Due to the equivocal positive result seen 

only at the high dose (200 mg/kg) in the original study, we conducted a second assay at a 

second independent laboratory, using the same dose levels, male mice, but with a 

different strain of mouse. 

Seven mice/dose group were sacrificed approximately 24 hr (control and test article 

treatment groups), and 48 hr (control and 200 mglkg groups only) after treatment, and 

bone marrow was evaluated for cytotoxicity and micronucleus formation. A vehicle 

control group and a urethane positive control group (this group contained 5 mice only and 

was sacrificed at 24 hr) were treated similarly and evaluated concurrently with the treated 

test material groups. 

There was no significant suppression of PCE among red blood cells at any dose level, 

which indicates the absence of bone marrow cytotoxicity_ There was a statistically 
significant increase in the frequency of micronucleated peE at all dose levels at both the 


24 and 48 hr time points. 


Based on these data, the test material was considered to be genotoxic. 


Test Material- Formulated Product AERO® 5715 Promoter (CT-752-02 & CT765-02) 

TEST MATERIAL COMPOSITION: 

PMN Substance -70% 

Isobutanol -20% 

Isobutyl carbamate -5% 

Diisobutyl carbonate -4.5% 

Quinoline -1% 

Acute Oral Toxicity (In Progress) - Results to date: 5/5 male rats dead at 5000 mglkg; 

4/5 male rats at 2000 mg/kg; 3/5 male rats dead at 1000 mg/kg. Dosing of additional five 

male rats at 500 mg/kg set for the week of 2110/03. 

Acute Dermal Toxicity (Complete - waiting for final report) - A group of five healthy 

male New Zealand White rabbits were dosed dermally at 2000 mglkg of body weight. 

The test article was kept in contact with the skin for 24 hours. Dermal responses were 

recorded at 24 hours postdose and again on day 7. Animals were observed at 1, 4 and 24 

hours postdose for mortality, toxicity and clinical signs and once daily thereafter for 

seven days for mortality only. 

Four of five animals survived the 2000 mg/kg dermal application. One animal died on 

day 4. Instances of few feces were noted at the 24-hour observation in two animals. 

Body weight changes were normal in % survivors. One animal lost weight. Dermal 

responses were absent to well defined at 24 hours and absent on day 7. 

Based on these results, the acute dermal (rabbit) LD50 is greater than 2000 mg/kg. 

Primary DermaVOcular Irritation (Complete - waiting for final report) - The test 

material was applied to one intact site (0.5 ml/site) on the clipped back of each of three 

New Zealand White rabbits for an exposure period of 4 hours. During the 4 hour 

occluded exposure the test sites were examined at 3 minutes and gain at 1 hour postdose. 

At 4 hours the wrappings were removed and the skin reactions were scored at 24, 48 and 

72 hours after patch removal. 

There was no erythema or edema noted at any observation period. The modified Primary 

Dermal Irritation Index is O. 

Based on these data, the test material was non-irritating to rabbit skin. 
The same three rabbits used in the dermal portion of the study were also used to assess 

the ocular effects of the test materiaL 

In this study, a single application of the test material (0.1 ml) to the eyes of three New 

Zealand Albino rabbits produced conjunctival irritation in 3/3 unwashed and 3/3 washed 

eyes, which cleared in all eyes by 72 hours. There was no iritis or corneal opacity noted 

at any observation period. There were no abnormal clinical signs noted during the 

observation period. 

Based on these data, the test material is considered to be a minimal-mild eye irritant 

in rabbits. 

Guinea Pig Sensitization (Buehler) - In progress 

In Vivo Mouse Micronucleus Assay - Based on the results of a dose rangefinding 

assay, the maximum tolerated dose was estimated to be 1500 mg/kg. In the definitive 

assay, the test material was mixed with 21.02% isobutanol in cell culture grade water. 

The doses were administered via oral gavage to six males per dose level at each 

scheduled harvest timepoint. The dose levels were 375, 750 or 1500 mglkg. Five 

animals were dosed with the test material at 375 or 750 mglkg and five animals dosed 

with the positive control article were euthanized -24 hours after dosing for extraction of 

the bone marrow. Five animals per harvest timepoint dosed with the test material at 1500 

mg/kg and five animals per harvest timepoint dosed with the vehicle control were 

euthanized 24 or 48 hours after dosing for extraction of the bone marrow. At least 2000 

PCEs per animal were analyzed for the frequency of micronuclei. Cytotoxicity was 

assessed by scoring the number of PCEs and normochromatic erythrocytes (NCEs) in at 

least the first 500 erythrocytes for each animal. 

The vehicle control article, 21.02% isobutanol in cell culture grade water, induced signs 

of slight hypoactivity and/or ataxia in all of the animals immediately postdose; all 

animals were normal by 1 hour postdose. The test material, induced slight hypoactivity 

and ataxia, as well as irregular respiration, squinted eyes, recumbency, and labored 

respiration. Six of the eighteen animals dosed at 1500 mglkg were found dead 2 days 

after dose administration. 

The test material induced a statistically significant increase in micronucleated PCEs at the 

high dose at the 48-hour harvest period. In addition, the test material was cytotoxic to the 

bone marrow (I.e., a statistically significant decrease in the PCE:NCE ratios) at the 48­

hour harvest timepoint. 

Based on these results, the test material was considered to be genotoxic at a dose 

level that was close to the toxic limit. 

Ecological Endpoints: Final Reports To Be Supplied To EPA Upon Receipt 

Acute Toxicity To Daphnia magna - 48-hour EC50 is 7.7 mgIL; NOEC 4.0 mgIL 
Acute Toxicity To Rainbow Trout - 96-hour LC50 is 7.1 mgIL; NOEC 4.0 mgIL 

Acute Toxicity To Green Algae - In Progress 

28-Day Biodegradation (Modified Sturm Test) -17.5% degradation 

RISK ASSESSMENT 


Introduction: 

Risk evaluation is based on hazard and exposure assessments. Hazard refers to the toxicity of the 

material and exposure refers to contact with the material. Human and environmental exposure to 

the PMN substance is predicted to be low. The PMN substance is manufactured outside of the 

United States. Only formulated products containing 15-50% PMN substance will be imported 

into the US. As such. data on the product as it is intended for use is more appropriate for 

assessing potential toxicity and risk to human health and the environment. 

Health Effects: 

Mutagenicity tests with the PMN Substance (Purity of 98+%) provided the following results: 

Ames SalmonellalE.Coli Assay Not mutagenic; In vitro Chromosomal Aberrations Assay in 

Human Lymphocytes - Not Clastogenic; In vivo Mouse Micronucleus Assay - Genotoxic 

Specific toxicological properties of a formulated product, containing -70% PMN substance, are 

as follows: acute oral (rat) LD50 is expected to be >500<1000 mglkg (in-progress) - this would 

result in a "harmful" classification; acute dermal (rabbit) LD50 >2000 mglkg - Not classified; 

non-irritating to rabbit skin; minimal-mildly irritating to rabbit eyes; dermal sensitization 

(Buehler method) - in progress; in vivo Mouse Micronucleus Assay considered genotoxic at a 

dose level that was close to the toxic limit. 

Environmental Effects: 

Specific environmental results, to date, indicate that for fish and Daphnids the PMN substance 

would be classified as " moderately toxic" by standard acute toxicity rating scales. Test results 

include an acute 96-hour LC50 to rainbow trout of 7.1 mg/L, and an acute 48-hour EC50 to 

Daphnia magna of7.7 mg/L. Acute toxicity testing in green algae is currently in progress. 

Assessment of biodegradability (Modified Sturm) indicated partial degradation, at 17.5%; 

however, the overall product assessment is not readily biodegradable. 

Exposure: 

The PMN substance will be manufactured outside of the US in our Atequiza, Mexico plant; 

therefore, eliminating this exposure/release scenario. However, the PMN substance will be 

manufactured using a closed system, where possible. This will be supplemented by the use of 

personal protective equipment, such as gloves and eye protection. Formulated products 

containing 15-70%, PMN substance will be imported to either a warehouse or directly to the 

customer mine site, no handling or processing of the PMN substance will occur during this 

activity. 

At the customer mine site the formulated product containing the PMN substance will be metered 

in by pump or gravity fed to the floatation cell in the closed-loop water recirculation circuit. 

Usage of the formulated product is in the range of - 10-50 glton of ore, with the ore comprising 

about 30% of the slurry. Therefore, the circuit concentration of the PMN substance is 

approximately 10-50 ppm. 
The continuous and recycling nature of modern mineral processing operations minimize worker 

exposure and environmental release at customer sites. In flotation operations, human exposure is 

'greatly minimized by use of automated continuous operation, minimal staffing and consistent 

industrial hygiene practices common to the industry. It is predicted that these products will be 

used at -3-5 mining sites over the next 3 years. The typical floatation operation would average 

about 6-12 operators (total for all shifts). Typically, impervious gloves, protective clothing and 

ventilation are employed as standard industrial hygiene measures. 

Continuous recycling operations, low concentrations of PMN substance and high selectivity for 

metal-bearing sulfide particles also result in minimal environmental release. Destruction or the 

entrained PMN substance occurs in the ensuing smelting operations. Smelting occurs at high 

temperatures (900-1000C) and has a long residence time (0.5-1.0 hrs). This will destroy any 

remaining PMN substance by oxidation. 

Risk Evaluation: 

Although the PMN substance was shown to be genotoxic in the Mouse Micronucleus Assay, we 

believe that the PMN substance poses a minimal risk to human health and the environment. This 

conclusion is based on the fact that the potential hazards can be mitigated by the use of 

appropriate personnel protection equipment, and due to nature of the mineral processing 

operation including tremendous dilution, potential for human or environmental exposure is low.