Exhibit 31.1



CERTIFICATION



I, Thomas Looby, certify that:



| | (1) | I have reviewed this annual report on Form 10-K/A (Amendment
No. 1) of Ekso Bionics Holdings, Inc.;
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| | (2) | Based on my knowledge, this report does not contain any
untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances
under which such statements were made, not misleading with respect to the period covered by this report;
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| | (3) | Based on my knowledge, the financial statements, and other
financial information included in this report, fairly present in all material respects the financial condition, results of operations
and cash flows of the company as of, and for, the periods presented in this report;
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| | (4) | The company’s other certifying officer(s) and I are
responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and
15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules
13a-15(f) and 15d-15(f)) for the company and have:
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| | (a) | Designed such disclosure controls and procedures, or caused
such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to
the company, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during
the period in which this report is being prepared;
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| | (b) | Designed such internal
control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision,
to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for
external purposes in accordance with generally accepted accounting principles;
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| | (c) | Evaluated the effectiveness of the company’s disclosure
controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures,
as of the end of the period covered by this report based on such evaluation; and
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| | (d) | Disclosed in this report any change in the company’s
internal control over financial reporting that occurred during the period covered by the annual report that has materially affected,
or is reasonably likely to materially affect, the company’s internal control over financial reporting; and
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| | (5) | The company’s other certifying officer(s) and I have
disclosed, based on our most recent evaluation of internal control over financial reporting, to the company’s auditors and
the audit committee of the company’s board of directors (or persons performing the equivalent functions):
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| | (a) | All significant deficiencies and material weaknesses in
the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the company’s
ability to record, process, summarize and report financial information; and
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| | (b) | Any fraud, whether or not material, that involves management
or other employees who have a significant role in the company’s internal control over financial reporting.
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|Date: December 27, 2017 |                            
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|                        |                            
|                        | /s/ Thomas Looby           
|                        | Thomas Looby               
|                        | Principal Executive Officer