OVX 

### r a t 

### irl minl EL : 

# 1s**~kgf da** **y** 

### Bisphen o l A lmm rat 

## ir4 min L EL..: 

# 2 m9n<,gld a y ma x

H DT: 1000 mg/kg/ d ay

OVX r a t o r a l ma x H D T : 

# 6oo - mglkg/ da y 

### G e n i stein l mm rat 

## ir4 min L EL..: 

# 1 m!}tkg!da y max HD T: 5 mglkg/da y

OVX r at o r a l minLEL 

# 6o ffiw'k:gtda yOVX _ r a t _ ir4 min L E L : 1 00 mg/kg/da y 

### M e t ho xy ch l or**mm rat** **r4** m i n l E L : 50 mg/kg/da y maxHDT: 200 mglkg/ da y

OVX r a t o r a l min lEL 

# 5o ffiwk:gt da y 

## o , p'·DDT lmm

_ rat

_ i r4 min l El: 1 mglkg

OVX r a t o r a l m i n l E l: 

# 5o**g/d y**  OVX _ mouse _ oral

OVX _ mouse _ i r4

## lmm _ rat _ ora l maxHDT: 400 mg / kg

/ da{ ,.--·· 

## 5 , ___ ....


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## ;.-:_-· 

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# Buty lpa rab e n lmm_ r at_ inj m i nlEL : 70 mglkg/day



# .. -·· 

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# .·· .. -· 

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**··---~---···· ··**  **·** 

# ··-... ..-·· · 

# s < OVX _ rat _ i nj 

# · 

# .. _ 

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_ 

# ... --··· ·

- 

# .. _ 

# ······- 

# ... m in lEL: 800 mglkg/da y · ·· - ..... . 

# ---... ···----r,------·· _ . . - 

# ... ·.. . 

# .. -·· ·-. ; .-··· 

# ·- ... 

# ·- 

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# ·., 

# ········ s ···· .. · OV

X _ rat _o ral 

# · 

# .. _ 

## ·- 

# .. __ _ _ 

## ···-.. OVX mouse ora l 

# · - 

# .. .

_ _ 

## ·· **ma ~HD**  **f:"** 1000 mg/kg/da y 

# 5 

# · -. .. ·- 

# ... __ _ _ 

# .. -·· · ·--------- :-·· · ···'

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_ _ 

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# : :: :

5 _ . .--- OVX _ mouse _ inj m i nLEL: 50 mglkglda y

## l mm_ r at_o r a l m in LEL: 1 e-04 mg**(t ta** **<~os :** 

O VX _ r at _ ir4 maxHDT: 200 mglkg/day 

# Diethy l stilbestro l l mm_ r at_ i n j m i n LEL: 5e - 05 m g/kg/da y m a

x HD T: 5e-05 m g/kg / da y

OVX _ r

at

_ oral 4-Nonylphenol

l rrrn _ r at _ ir-4 m in l EL: 1 00 mglk gl da y maxH D T : 2 00 mglk g/ da y

O V X

_ r

at _ o ra l 

## OVX _ mous e _ora l OVX_mou s e_ in j

OVX

_ mouse_ir4**OVX i~** 

l mrn _ r a t _ or

a l**OVX rat** **i~** 

### 4-(1 , 1 , 3 , 3· Tetramethy l butyl)phenol l mm

_ rat

_ if'1 m i nL E L: 200 mglkg/da y

OVX_rat _ oral 

### Ethy l paraben

l mm rat tf'4 minl E L : 18o rT.gikglday 

### max

H DT : 1000 mglkg/day

OVX

_ rat

_ oral OVX _ mouse _ oral

OVX _ mouse _ t f1

OVX mouse o r al 

### HoT

: 1000 ffio.tkolda y

OVX mouse**i~** 

### maxHDT:1ooo

### ~g/da**y**

### lmm _rat_or al

ovx_r at_• rl Benzophen one 

### lnvn_r at _ill min LEL : 500 mglkglday max H DT : 200 mglkg/day



### OVX_ra t _or

a l OVX _ mouse _ ora l

OVX

_ mouse _ i!l

## lmm_ r at_o r a l m a

x H DT : 800 mg / k g(

O

VX_ r at_ i n j

l mm

_ r at _ o r

a l**OVX ra** **i~** 

# Methylparaben l m m_ r at_ i n j m i n L E L: 5 5 mg/k g/d a y ma x HDT : 8 0 m g/ k g/ d a

y

OVX _ r

a t _ o r a l B e nz( a) anthrace ne l mm

_ r

at _i f'1 m i n

l EL: 1 rngl k gf da y ' · ·· · · · ·· · · .. . 

## O V X _ m ou se _ o r a l
O

V X

_m o u s e_inj

- - - - -

.. -, -, -.,_ ,_ --- - - - .. _

, , OVX 

### mo use oral

## --**---'\ -----** **ma _:::** **,., :**  300 rriJ.rkol d a y

OVX_r a t_oral OVX mouse 111 

### max H D T-:- 300 rnQikgt d a y**OV ~** 



## lmm _ r a t _ ora l 

## l ·
OVX _r at _ in

j _ 

# . .. 

# -·· 

# .. -· ··

_ 

# .. · 

# ·- .. _



# .. ·· ·· 4 - 0c ty lphenol l mm

_ r

a t _ if'1 ma x

H D

T: 200 mglkgf da y

OVX_r a t _ or a l 

# Propy l paraben l mm_ r at_in j m i n LE L: 6 5 m g/kg/ d a y

_ 

# . .

-··· OVX _ r

a t _ o r al _ 

# .... . - ··
_ 

# .. -·· OVX _ mouse _ oral

OVX _ mouse _ i f'1



## _ _ . .. -·· avx _ m o u se _ i n

j __ .. . . . - - ·· ma xHD T : 1 000 mg/kg/ d ayl mm _ r a t

_ or

a l**OVX rat** **i~**

l mm

_ r a t

_ or

a l**OVX rat** **i~** 

### Permethrin**fTVII ral** **i~** m i nL El : 800 mgfkglda y

OVX rat o r a l maxHD T: 

# 1 so - mglkg/da y 

### Reserpine**mm rat** **i~**

O VX_rat_oral OVX _ mouse _ o ra l**OVX mouse** **i~**l mrn _ r a t _ or

a l

OVX

_ rat

_ ir-4 

### Apig e n i n l nvn_r a U r-4

OVX r a t o r a l m i nl E L: - 5

### ~g!**da y** 



### Daid z e i n**lrrvn rat** **i~** ma xHDT: 200 mglkg!d a y ' ·· ··· · - ·· · · . . . OVX _ mouse _ oral**OVX mouse** **i~**

- - - - -

.. -, - , - . , _ ,_ -- -- -- -- - - , , OVX 

### mouse oral 

### /-c -- -l,-- ---- - · _ , - m _ _ _ i "l! _ n L E C 600 mO.rk.otday**OVX mouse** **i~** OVX

_ r

a t _ oral