## UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460



## MEMORANDUM

DATE : Decembe r 19, 2012 OFF I CE OF CHEMICAL SAFETY

AND POL L UTION PREVENTION



## SUBJEC T : Flumioxazin: 

## Acute and Chronic D i etary (Food and Water) Exposu r e and Risk Assessments for t he Proposed Uses on Artichoke, Cabbage, Olive, Pomegranate, and Prick l y Pear Cactus.

PC Code: 129034


### Decision No.: 4508 1 0


### Petition No.: I F7886 

### DP Barcode: 0406069 

### Registration No.: I 00-727 

### Regulatory Action: Section 3 Registratio n 

### Risk Assessment Type: 

## Dietary

TXRNo.: NA Case No.: NA
CAS No.: 103361-09-7

40 

### CFR: 180.568 

### MRIDNo.: NA



## REV I EWER : Richard Duncan, Associate Toxicolog i st Department of Pesticide Regula t ion
Californ i a Environmental Protection Agency

Sheila

# P~~r, C h emist

# ~~**\£,~** Risk Assessment Branch VI

Hea l th Effects Division (7509P)

THROUGH : Seyed Tadayon, Chemist

# ~~ Dietary Exposure SAC (7509pf

Christine

# li**ng:~~** Act i ng Branch Chief 

# /J /

# ~ Risk Assessment Bra n ch V I

# {/?#/-~-~-- Health Effects D i vision (7509P)

TO : Andrew Ertman, Barbara Madden RM05

R i sk Integration, M i nor Use, and Emergency Response Branch Registration D i vis i o n (7505P)



## This document was originally prepared by California Department of Pesticide Regulation
(1 

## 001 I Street, Sacramento, CA 

## 95812; submitted 0811712012)

### Flumioxazin Dietary Exposure and Risk Assessment DP Number: 406069

PC Code: 129034

______________________________________________________ ________________________________

Page 2 of 17 

## Executive Summary

At the request of the Registration Division, an acute and chronic dietary risk assessment for flumioxazin was conducted using the Dietary Expo sure Evaluation Model DEEM

FCID , Version 3.16 which uses food consumption data from the U.S. Department of Agriculture’s National Health and Nutrition Examination Survey, What We Eat in

Americ a, (NHANES/WWEIA) from 2003

- 2008

. This analysis was performed to estimate the acute and chronic dietary (food and drinking water) risk resulting from current and
new uses of flumioxazin on artichoke, cabbage, olive, pomegranate

, and prickly pear

cactus.

Acute Dietary (Food and Drinking Water) Exposure Results and Characterization

An unrefined, acute dietary exposure assessment using tolerance levels , processing factors, and assuming 100% crop treated (CT) for the proposed commodities was
conducted for the general U.S. population and various population subgroups . The estimated drinking water concentration of flumioxazin was provided by the Environmental Fate and Effects Division (EFED) and incorporated directly into the acute

assessment. An estimated envi ronmental concentrations (EECs) for flumioxazin and its major degradates (482

- HA and APF) under the use as an aquatic herbicide of 400 ppb
was estimated for acute exposure.

There were no appropriate toxicological effects attributable to a single exposure (dose) for the general population or any other population subgroups except females 13

- 49 years
old ; therefore

, these population subgroups were not included in this assessment. For food and drinking water, the acute dietary risk estimate is below HED’s lev el of concern (<100% of the acute population adjusted dose (aPAD)) at the 95 th 

## percentile of exposure. The acute dietary exposure estimate for females 13

- 49 years old is 0.0 2 26 07 mg/kg/day ( 75 % of the aPAD)

.

Chronic Dietary (Food and Drinking Water) Expos ure Results and Characterization

The chronic dietary exposure and risk estimates are conservative since they assume that 100% of crops are treated , processing factors, and that the residues are present at the

t olerance levels. The EECs for flumioxazin and its major degradates (482

- HA and APF) under the use as an aquatic herbicide is 142 ppb. C ombined chronic dietary exposure estimates for food and drinking water are well below HED’s level of concern. Using the

DEEM

- FCID software, dietary exposure is est imated at 0.0039 3 2 mg/kg/day for the general U.S. population, which is equivalent to 20 % of the chronic Population Adjusted Dose (cPAD), and 0.0 08753 mg/kg/day, equivalent to 4 4 % of the cPAD for all infants ( < 1year old ) , the population subgroup with the h ighest estimated chronic dietary exposure

to flumioxazin

.

Cancer Dietary (Food and Drinking Water) Exposure Results and Characterization

### Flumioxazin Dietary Exposure and Risk Assessment DP Number: 406069

PC Code: 129034

______________________________________________________ ________________________________

Page 3 of 17 

## F lumioxazin is classified as a “ N ot likely to be carcinogenic to humans.” Therefore, a cancer dietary exposure anal ysis is not required

.

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose. This is the population a djusted dose (PAD), which HED has
concluded will result in no unreasonable adverse health effects. The PAD is the Reference Dose (RfD) divided by the FQPA Safety Factor. Dietary risk is expressed as a percentage of the PAD. For acute and non

- cancer chro nic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD. References which
discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site: “Available Information on Assessing Exposure from Pesticides, A User’s Guide”, 6/21/2000, web link: http://www.epa.gov/fedrgstr/EPA

- PEST/2000/July/Day

- 12/6061.pdf ; or see SOP 99.6 (8/20/99).

The most recent dietary risk assessment for flumioxazin was conducted by S. Piper,

D P# 401806

, 0 8 / 08 / 2012

.

II. Residue Information

Flumioxazin belongs to the N

- phenylphthalimide class of herbicides (Group 14) and is currently registered for pre

- and post

- emergence applications on a variety of fruit, vegetable, and field crops for the control of susceptible wee ds. Tolerances are currently established for residues of the herbicide flumioxazin in/on various plant commodities, at levels ranging from 0.02 to 8. 0 ppm (as listed in e

- CFR 40 §180.568 [a] , u pdated August

, 20 12 ).

The residue of concern for both the tol erance expression and risk assessment in plants is
flumioxazin. No livestock tolerances have been established. A tolerance for combined
residues of flumioxazin and its metabolites APF (3

- oxo

- 4

- prop

- 2ynyl

- 6

- amino

- 7

- fluoro

3,4

- dihydro

- 1,4

- benzoxazin) and 48 2

- HA (N

- (7

- fluoro

- 3,4

- dihdyro

- 3

- oxo

- 4

- prop

- 2

- ynyl

2H

- 1,4

- benzoxazin

- 6

- yl)cyclohex

- 1

- ene

- 1

- carboxamide

- 2

- carboxylic acid) in freshwater
fish.

The proposed use and the submitted data support the following tolerances based on the
OECD tolerance calculation f or residues of flumioxazin in/on the following commodities:

Artichoke

................................ ................................ ................................ .... 0.0 2 ppm Cabbage

................................ ................................ ................................ ...... 0.0 2 ppm Olive

................................ ................................ ................................ ........... 0.0 2 ppm Pomegranate

................................ ................................ ............................... 0.0 2 ppm Prickly Pear Cactus Fruit

................................ ................................ ........... 0. 07 ppm Prickly Pear Cactus Pads

................................ ................................ ........... 0. 06 ppm

### Flumioxazin Dietary Exposure and Risk Assessment DP Number: 406069

PC Code: 129034

______________________________________________________ ________________________________

Page 4 of 17 

## DEEM 7.81 processing factors were used for all proc essed commodities, with the exception of tomato which used the empirical processing factor of one. A tomato processing factor of 1 is based on an exaggerated (~5x) crop field trial study in which no
residues were recovered; therefore, a processing study i s not required (47005106.der , D. Rate, 6/19/ 07). 100 %CT was assumed for all commodities in this assessment.

III. Drinking Water Data

References: Drinking Water Assessment for a Section 3 New Use for Flumioxazin End

Use Products Chateau WDG and Valor WDG Applications to Agate and Prickly Pear Cactus, Olive, Pomegranate, Cabbage, and Artichoke

, D39 8751 , Larry Liu, 9/05 /2012.

A Tier I screening level drinking water assessment was conducted to support the human
health risk asses sment for the proposed new use for artichoke, cabbage, olive, pomegranate, and prickly pear cactus. EFED have indicated that the drinking waters will not change from those last used which were based on the aquatic application rates of the
herbici de since the maximum single applicat ion rate for the proposed uses (0.36 lb ai/A) is lower than the maximum single application rate (0.38 lb ai/A) used in the previous drinking water assessment (D401806, S.Piper, 08/08/12)

.

T he estimated environmental concentrations ( EECs ) for flumioxazin and the metabolites

482

- HA and APF are the residues of concern in drinking water. In order to be conservative, EECs for flumioxazin and its major degradates (482

- HA and APF) as a result of the use as an aquatic herbicide of 0.400 ppm ( peak day

- 0) for acut e exposure and of 0.142 ppm (30

- days) for chronic exposure w ere used in the dietary analyses . Table 1 lists degradate identified and their relative concentrations. Water residues were incorporated in the DEEM

- FCID into the food categories “water, direct, a ll sources” and “water, indirect, all sources .” The model and its description are available at the EPA
internet site: http://www.epa.gov/oppefed1/models/water/

.

Table 1. EECs (ppb) From the Sub surface Application of Flumioxazin as an Aquatic Herbicide Compound Peak EEC (Day 0) (ppb) EEC at Days 30 and

after (ppb)

Acute Chronic

Flumioxazin 400 10.4

482

- HA

- 21.6

APF

- 110.1

THPA

- 88.9

Total EEC 1 

## 142.1

1 

### Total E E C = Sum of Flumioxazin + 482

- HA + APF

### Flumioxazin Dietary Exposure and Risk Assessment DP Number: 406069

PC Code: 129034

______________________________________________________ ________________________________

Page 5 of 17 

## IV

. DEEM

- FCID Program and Consumption Information

Flumioxazin acute and chronic dietary exposure assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database

DEEM

- FCID, Version 3.1 6, which incorporates consumption data from USDA’s NHANES/WWEIA. This dietary survey was conducted from 2003 to 2008. The data are based on the reported consumption of more than 20,000 individuals over two non

consecutive survey days. Foods “as consumed ” (e.g., apple pie) are linked to EPA

defined food commodities (e.g., apples, peeled fruit

- cooked; fresh or N/S; baked; or
wheat flour

- cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups. However, for acute exposure assessment, consumption data are retained as individual consumption events. Based on analysis of the 2003

- 2008 WWEIA consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1

- 2, children 3

- 5, children 6

- 12, youth 13

- 19, adults 20

- 49, females 13

- 49, and adults 50+ years old.

For a chronic dietary exposure assessment, an estimate of the residue level in each food
or food

- form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food form to produce a residue intake estimate. The resulting residue intake estimate for each food/food form
is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure is performed for each population subgroup.

For an acute e xposure assessment, individual one

- day food consumption data are used on
an individual

- by

- individual basis. The reported consumption amounts of each food item can be multiplied by a residue point estimate and summed to obtain a total daily pesticide

expos ure for a deterministic exposure assessment, or “matched” in multiple random pairings with residue values and then summed in a probabilistic assessment. The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating relevant commodities/food forms) and a per

capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis. In accordance with HED policy, per capita exposure and risk are reported for

a nalyses performed at all levels of refinement. However, for deterministic assessments, any significant differences in user vs. per capita exposure and risk are specifically
identified and noted in the risk assessment.

V. Toxicological Information

The fi ndings of the flumioxazin risk assessment team, relative to dietary exposure, are
summarized in Table 2 (below). In accordance with the EPA Draft Guidelines for

### Flumioxazin Dietary Exposure and Risk Assessment DP Number: 406069

PC Code: 129034

______________________________________________________ ________________________________

Page 6 of 17 

## Carcinogen Risk Assessment (July, 1999), flumioxazin was classified as “not likely to be

carci nogenic to humans.”

Table 2

. Summary of Toxicological Doses and Endpoints for Use in Human Health Dietary

Risk Assessment for Flumioxazin.

Exposure/

Scenario Point of

Departure Uncertainty/

FQPA Safety

Factors RfD, PAD,

Level of
Concern Study and T oxicological

Effects

Acute Dietary (General Population, including Infants and Children) No endpoint attributable to a single dose (exposure) was identified in the available

studies, including the developmental toxicity studies in rats and rabbits.

Acut e Dietary

(Females 13

- 49 years of age) NOAEL = 3

mg/kg/day UF A 

### = 10x

UF H 

### = 10x

FQPA SF = 1X

Total UF = 100X Acute RfD =

NOAEL UF =

0.03 mg/kg/day

aPAD = 0.03 mg/kg/day Oral developmental and

supplemental prenatal studies
in the rat.

LOAEL = 10 mg/kg /day
based on cardiovascular effects (especially ventricular septal defects in fetuses).

Chronic Dietary (All Populations) NOAEL = 2

mg/kg/day UF A 

### = 10x

UF H 

### = 10x

FQPA SF = 1X

Total UF = 100X Chronic RfD

FQPA SF = 0.02 mg/kg/day

cPAD = 0.02 mg/kg/da y 2

- year chronic/carcinogenicity

study in the rat.

LOAEL = 18 mg/kg/day
based on increased chronic nephropathy in males, and decreased hematological parameters in females (Hgb, MCV, MCH, and MCHC).

Cancer (oral, dermal, inhalation) Classification: “Not likely to be Carcinogenic to Humans” based on

the lack of carcinogenicity in a 2

- year rat study, an 18

- month mouse study, and a battery of mutagenic studies.
Point of Departure (POD) = A data point or an estimated point that is derived from observe d dose

- response data and used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF =
uncertai nty factor. UF A = extrapolation from animal to human (intraspecies). UF H = potential variation in sensitivity among members of the human population (interspecies). UF L = use of a LOAEL to extrapolate a NOAEL. UF S = use of a short

- term study for long

- te rm risk assessment. UF DB = to account for the absence of key data (i.e., lack of a critical study). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = ch ronic). RfD =
reference dose

.



## V I

. Results/Discussion

As stated abov e, for acute or chronic dietary assessments, HED is concerned when dietary risk exceeds 100% of the PAD. The DEEM

- FCID analyses estimate the dietary

### Flumioxazin Dietary Exposure and Risk Assessment DP Number: 406069

PC Code: 129034

______________________________________________________ ________________________________

Page 7 of 17 

## exposure of the US population and various population subgroups. The results reported in
Table 3 (below) a re for the general US population (total), all infants <1, children 1

- 2,
children 3

- 5, children 6

- 12, youths 13

- 19, females 13

- 49, adults 20

- 49, and adults 50+ for chronic exposure and females 13

- 49 for acute exposure.

Results of Acute Dietary Exposure A nalysis

Flumioxazin acute dietary (food + water ) exposure estimates using the DEEM

- FCID
software are below HED ’s level of concern for females 13

- 49 . The acute dietary exposure for the females, 13

- 49 years old, utilized 75 % of the aPAD at the 95 th



## percent ile

.

Results of Chronic Dietary Exposure Analysis

Flumioxazin chronic dietary (food + water) exposure estimates using the DEEM

- FCID
software are below HED ’s level of concern for the U.S. population and each of the population subgroups

. Chronic dietary e xposure utilized 20 % of the cPAD for the U.S. population. T he chronic dietary exposure for the highest reported exposed population subg roup, all infants (<1 year old) , was 4 4 % of the cPA D.

Table 3 . Summary of Dietary Exposure and Risk for Flumioxazin.

Population Subgroup 1 

## DEEM Acute Dietary Analysis, 95 th 

## Percentile DEEM Chronic Dietary Analysis

aPAD (mg/kg) Exposure

(mg/kg/day) %

aPAD cPAD (mg/kg/day) Exposure

(mg/kg/day) %

cPAD

General U.S. Population

NA 2 

## 0.02 0.0039 32 20

All I nfants (< 1 year old) 0.02 0.0 08753 44

Children 1

- 2 years old 0.02 0.00 68 1 1 34

Children 3

- 5 years old 0.02 0.00 5959 30

Children 6

- 12 years old 0.02 0.00 4 253 21

Youth 13

- 19 years old 0.02 0.00 3 116 16

Adults 20

- 49 years old 0.02 0.003 715 1 9

Adults 50+ years old 0.02 0.003 6 3 3 1 8

Females 13

- 49 years old 0.03 0.0 2 26 07 75 0.02 0.003 692 1 9

1 Values for the population with the highest ri sk for each type of risk assessment are bolded

. 2 NA = Not Applicable; no acute dietary endpoint was identified for these population subgroups



## VII. Characterization of Inputs/Outputs

### Flumioxazin Dietary Exposure and Risk Assessment DP Number: 406069

PC Code: 129034

______________________________________________________ ________________________________

Page 8 of 17 

## The assumptions made in this assessment are conservative, and are v ery likely to result in exposure and risk values that considerably overestimate actual dietary exposure to
flumioxazin. Although not needed at this time, t he analy se s could be further refined through the use of average residues based on field trial data, percent crop treated data and/or preparation/cooking factors. Since risk estimates are below HED ’s level of concern, a more highly refined analysis is not needed at this time

.

VI I I

. Conclusions

This highly conservative, unrefined analysis demonstrates that the requested uses for flumioxazin will not result in acute and chronic dietary risk estimates that exceed HED’s level of concern for any of the regulated populated subgroups, including those comprised
of infants and children.

I X

. List of Attachmen ts

Attachment 1: Acute Food plus Water Residue Input File
Attachment 2: Acute Results File Attachment 3: Chronic Food plus Water Residue Input File
Attachment 4 : Chronic Results File

.

### Flumioxazin Dietary Exposure and Risk Assessment DP Number: 406069

PC Code: 129034

______________________________________________________ ________________________________

Page 9 of 17 

## Attachment 1: Acute Food plus Water Residue Input File

US EPA Ver. 3.16, 03

- 08

- d

DEEM

- FCID Acute analysis for FLUMIOXAZIN

Residue file name: C: \ Deemfcid \ FLUMIOXAZIN_ACUTE2.R08 Analysis Date 10

- 15

- 2012 Residue file dated: 10

- 15

- 2012/10:57:13

Reference do se: aRfD = 0.03 mg/kg bw/day NOEL = 3 mg/kg bw/day Comment: Food + Drinking Water

---------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment

Code Grp Food Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ------- 1400003000 14 Almond 0.020000 1.000 1.000

1400003001 14 Almond

- babyf ood 0.020000 1.000 1.000 1400004000 14 Almond, oil 0.020000 1.000 1.000 1400004001 14 Almond, oil

- babyfood 0.020000 1.000 1.000 1100007000 11 Apple, fruit with peel 0.020000 1.000 1.000 1100008000 11 Apple, peeled fruit 0.020000 1.000 1.000 1100008001 11 Apple, peeled fruit

- babyfood 0.020000 1.000 1.000 1100009000 11 Apple, dried 0.020000 8.000 1.000

1100009001 11 Apple, dried

- babyfood 0.020000 8.000 1.000 1100010000 11 Apple, juice 0.020000 1.300 1.000 1100010001 11 Apple, juice

- babyfood 0.020000 1.300 1.000 1100011000 11 Apple, sauce 0.020000 1.000 1.000 1100011001 11 Apple, sauce

- babyfood 0.020000 1.000 1.000 1202012000 12B Apricot 0.020000 1.000 1.000 1202012001 12B Apricot

- babyfood 0.020000 1.000 1.000

12 02013000 12B Apricot, dried 0.020000 6.000 1.000 1202014000 12B Apricot, juice 0.020000 1.000 1.000 1202014001 12B Apricot, juice

- babyfood 0.020000 1.000 1.000 0103015000 1CD Arrowroot, flour 0.020000 1.000 1.000 0103015001 1CD Arrowroot, flour

- babyfood 0.020000 1.000 1.000 9500016000 O Artichoke, globe 0.020000 1.000 1.000new us

Full comment: new use 0103017000 1CD Artichoke, Jerusalem 0.020000 1.000 1.000 9500019000 O Asparagus 0.020000 1.000 1.000 0902021000 9B Balsam pear 0.030000 1.000 1.000 0603030000 6C Bean, black, seed 0.0700 00 1.000 1.000 0603032000 6C Bean, broad, seed 0.070000 1.000 1.000 0603034000 6C Bean, cowpea, seed 0.070000 1.000 1.000 0603035000 6C Bean, great northern, seed 0.070000 1.000 1.000

0603036000 6C Bean, kidney, seed 0.070000 1.000 1.000 0603038000 6C Bean, lima, seed 0.070000 1.000 1.000 0603039000 6C Bean, mung, seed 0.070000 1.000 1.000 0603040000 6C Bean, navy, seed 0.070000 1.000 1.000 0603041000 6C Bean, pink, seed 0.070000 1.000 1.000 0603042000 6C Bean, pinto, seed 0.070000 1.000 1.000 1302057000 13B Blueberry 0.020000 1.000 1.000 1302057001 13B Blueberry

- babyfood 0.020000 1.000 1.000

1400059000 14 Brazil nut 0.020000 1.000 1.000

1400068000 14 Butternut 0.020000 1.000 1.000 0501069000 5A Cabbage 0.020000 1.000 1.000new us

Full comment: new use 0502070000 5B Cabbage, Chinese, bok choy 0.020000 1.000 1.000new us

Full comment: new use 0501071000 5A Cabbage, Chinese, napa 0.020000 1.000 1.000new us

Full comment: new use 0501072000 5A Cabbage, Chinese, mustard 0.020000 1.000 1.000new us

Full comment: new use

9500073000 O Cactus

110

- Uncooked; Fresh or N/S; Cook Meth N/S

0.070000 1.000 1.000 new us

Full comment: new use

210

- Cooked; Fresh or N/S; Cook Meth N/S

0.070000 1.000 1.000 new us

### Flumioxazin Dietary Exposure and Risk Assessment DP Number: 406069

PC Code: 129034

______________________________________________________ ________________________________

Page 10 of 17 Full comment: new use 0901075000 9A Cantaloupe 0.030000 1.000 1.000

0402076000 4B Cardoon 0.020000 1.000 1.000

1400081000 14 Cashew 0.020000 1.000 1.000

01030 82000 1CD Cassava 0.020000 1.000 1.000

0103082001 1CD Cassava

- babyfood 0.020000 1.000 1.000 0402085000 4B Celery 0.020000 1.000 1.000 0402085001 4B Celery

- babyfood 0.020000 1.000 1.000 0402086000 4B Celery, juice 0.020000 1.000 1.000

0402087000 4B Celtuce 0.020000 1.000 1.000 0902088000 9B Chayote, fruit 0.030000 1.000 1.000 1201090000 12A Cherry 0.020000 1.000 1.000 1201090001 12A Cherry

- babyfood 0.020000 1.000 1.000 1201091000 12A Cherry, juice 0.020000 1.500 1.000 1201091001 12A Cherry, juice

- babyfood 0.020000 1.500 1.000

1400092000 14 Chestnut 0.020000 1.000 1.000 0603098000 6C Chickpea, seed 0.070000 1.000 1.000 0603098001 6C Chickpea, seed

- babyfood 0.0 70000 1.000 1.000 0603099000 6C Chickpea, flour 0.070000 1.000 1.000 0902102000 9B Chinese waxgourd 0.030000 1.000 1.000 1500120000 15 Corn, field, flour 0.020000 1.000 1.000

1500120001 15 Corn, field, flour

- babyfood 0.020000 1.000 1.000 1500121000 15 Corn, field, meal 0.020000 1.000 1.000 1500121001 15 Corn, field, meal

- babyfood 0.020000 1.000 1.000 1500122000 15 Corn, field, bran 0.020000 1.000 1.000 1500123000 15 Corn, field, starch 0.020000 1.000 1.000 1500123001 15 Corn, field, starch

- babyfood 0.020000 1.000 1.000 1500124000 15 Corn, field, syrup 0.020000 1.000 1.0 00 1500124001 15 Corn, field, syrup

- babyfood 0.020000 1.000 1.000 1500125000 15 Corn, field, oil 0.020000 1.000 1.000 1500125001 15 Corn, field, oil

- babyfood 0.020000 1.000 1.000 2003128000 20C Cottonseed, oil 0.020000 1.000 1.000 2003128001 20C Cottonseed, oil

- babyfood 0.020000 1.000 1.000 1100129000 11 Crabapple 0.020000 1.000 1.000

0902135000 9B Cucumber 0.030000 1.000 1.000

1302136000 13B Currant 0.020000 1.000 1.000 1302137000 13B Currant, dried 0.020000 1.000 1.000 0103139000 1CD Dasheen, corm 0.020000 1.000 1.000

0802148000 8BC Eggplant 0.020000 1.000 1.000 1302149000 13B Elderberry 0.020000 1.000 1.000 0402152000 4B Fennel, Florence 0.020000 1.000 1.000

1400155000 14 Hazelnut 0.020000 1.000 1.000 1400156000 14 Hazelnut, oil 0.020000 1.000 1.000

8000157000 80 Fish

- freshwater finfish 1.500000 1.000 1.000

8000158000 80 Fish

- freshwater finfish, farm ra 1.500000 1.000 1.000

20 01163000 20A Flax seed, oil 0.400000 1.000 1.000 0301165000 3A Garlic, bulb 0.020000 1.000 1.000 0301165001 3A Garlic, bulb

- babyfood 0.020000 1.000 1.000 0103166000 1CD Ginger 0.020000 1.000 1.000 0103166001 1CD Ginger

- babyfood 0.020000 1.000 1.000 0103167000 1CD Ginger, dried 0.020000 1.000 1.000 1302174000 13B Gooseberry 0.020000 1. 000 1.000 1304175000 13D Grape 0.020000 1.000 1.000 1304176000 13D Grape, juice 0.020000 1.200 1.000 1304176001 13D Grape, juice

- babyfood 0.020000 1.200 1.000 9500177000 O Grap e, leaves 0.020000 1.000 1.000 9500178000 O Grape, raisin 0.020000 4.300 1.000 1304179000 13D Grape, wine and sherry 0.020000 1.000 1.000 0603182000 6C Guar, seed 0.070000 1.000 1.000 0603182001 6C Guar, seed

- babyfood 0.070000 1.000 1.000 1400185000 14 Hickory nut 0.020000 1.000 1.000 0901187000 9A Honeydew melon 0.030000 1.000 1.000

9500188 000 O Hop 0.050000 1.000 1.000 1302191000 13B Huckleberry 0.020000 1.000 1.000 0603203000 6C Lentil, seed 0.070000 1.000 1.000 1100210000 11 Loquat 0.020000 1.000 1.000

### Flumioxazin Dietary Exposure and Risk Assessment DP Number: 406069

PC Code: 129034

______________________________________________________ ________________________________

Page 11 of 17 1400213000 14 Macadamia nut 0.020000 1.000 1.000

1202230000 12B Nectarine 0.020000 1.000 1.000

0802234000 8BC Okra 0.020000 1.000 1.000

9500235000 O Olive 0.020000 1.000 1.000new us

Full comment: new use 9500236000 O Olive, oil 0.020000 1.000 1.000new us

Full comment: new use 0301237000 3A Onion, b ulb 0.020000 1.000 1.000 0301237001 3A Onion, bulb

- babyfood 0.020000 1.000 1.000 0301238000 3A Onion, bulb, dried 0.020000 9.000 1.000 0301238001 3A Onion, bulb, dried

- babyfood 0.02 0000 9.000 1.000 0603256000 6C Pea, dry 0.070000 1.000 1.000 0603256001 6C Pea, dry

- babyfood 0.070000 1.000 1.000 0603258000 6C Pea, pigeon, seed 0.070000 1.000 1.000

1202260000 12B Peach 0.020000 1.000 1.000

1202260001 12B Peach

- babyfood 0.020000 1.000 1.000 1202261000 12B Peach, dried 0.020000 7.000 1.000 1202261001 12B Peach, dried

- babyfood 0.020000 7.000 1.000 1202262000 12B Peach, juice 0.020000 1.500 1.000 1202262001 12B Peach, juice

- babyfood 0.020000 1.500 1.000

9500263000 O Peanut 0.020000 1.000 1.00 0 9500264000 O Peanut, butter 0.020000 1.890 1.000 9500265000 O Peanut, oil 0.020000 1.000 1.000

1100266000 11 Pear 0.020000 1.000 1.000

1100266001 11 Pear

- babyfood 0.020000 1.000 1.000 1100267000 11 Pear, dried 0.020000 6.250 1.000 1100268000 11 Pear, juice 0.020000 1.500 1.000 1100268001 11 Pear, juice

- babyfood 0.020000 1.000 1.000

1400269000 14 Pecan 0.020000 1.000 1.000 0802270000 8B Pepper, bell 0.020000 1.000 1.000 0802270001 8B Pepper, bell

- babyfood 0.020000 1.000 1.000

0802271000 8B Pepper, bell, dried 0.020000 1.000 1.000 0802271001 8B Pepper, bell, dried

- babyfood 0.020000 1.000 1.000 0802272000 8BC Pepper, nonbell 0.020000 1.000 1.000 0802272001 8BC Pepper, nonbell

- babyfood 0.020000 1.000 1.000 0802273000 8BC Pepper, nonbell, dried 0.020000 1.000 1.000 9500275000 O Peppermint 0.040000 1.000 1.000 9500276000 O Peppermint, oil 0.040000 1.000 1.000

140 0282000 14 Pistachio 0.020000 1.000 1.000

1203285000 12C Plum 0.020000 1.000 1.000

1203285001 12C Plum

- babyfood 0.020000 1.000 1.000 1203286000 12C Plum, prune, fresh 0.020000 1.000 1.000 1203286001 12C Plum, prune, fresh

- babyfood 0.020000 1.000 1.000 1203287000 12C Plum, prune, dried 0.020000 5.000 1.000 1203287001 12C Plum, prune, dried

- babyfood 0.020000 5.0 00 1.000 1203288000 12C Plum, prune, juice 0.020000 1.400 1.000 1203288001 12C Plum, prune, juice

- babyfood 0.020000 1.400 1.000 9500289000 O Pomegranate 0.020000 1.000 1.000new us

Full comment: new use 0103296000 1C Potato, chips 0.020000 1.000 1.000 0103297000 1C Potato, dry (granules/ flakes) 0.020000 6.500 1.000 0103297001 1C Potato, dry (granules/ flakes)

- b 0.020000 6.500 1.000

0103298000 1C Potato, flour 0.020000 1.000 1.000 0103298001 1C Potato, flour

- babyfood 0.020000 1.000 1.000 0103299000 1C Potato, tuber, w/peel 0.020000 1.000 1.000 0103299001 1C Potato, tuber, w/peel

- babyfoo d 0.020000 1.000 1.000 0103300000 1C Potato, tuber, w/o peel 0.020000 1.000 1.000 0103300001 1C Potato, tuber, w/o peel

- babyfood 0.020000 1.000 1.000 0902308000 9B Pumpkin 0.030000 1.000 1.000

0 902309000 9B Pumpkin, seed 0.030000 1.000 1.000 1100310000 11 Quince 0.020000 1.000 1.000 2001319000 20A Rapeseed, oil 0.400000 1.000 1.000 2001319001 20A Rapeseed, oil

- ba byfood 0.400000 1.000 1.000

0402322000 4B Rhubarb 0.020000 1.000 1.000 2002330000 20B Safflower, oil 0.500000 1.000 1.000 2002330001 20B Safflower, oil

- babyfood 0.500000 1 .000 1.000

### Flumioxazin Dietary Exposure and Risk Assessment DP Number: 406069

PC Code: 129034

______________________________________________________ ________________________________

Page 12 of 17 0600347000 6 Soybean, seed 0.020000 1.000 1.000 0603348000 6C Soybean, flour 0.020000 1.000 1.000 0603348001 6C Soybean, flour

- babyfood 0.020000 1.000 1.000 0600349000 6 Soy bean, soy milk 0.020000 1.000 1.000 0600349001 6 Soybean, soy milk

- babyfood or in 0.020000 1.000 1.000 0600350000 6 Soybean, oil 0.020000 1.000 1.000 0600350001 6 Soybean, oil

- babyfood 0.020000 1.000 1.000 9500352000 O Spearmint 0.040000 1.000 1.000 9500353000 O Spearmint, oil 0.040000 1.000 1.000 0902356000 9B Squash, summer 0.030000 1.000 1.000

090235 6001 9B Squash, summer

- babyfood 0.030000 1.000 1.000 0902357000 9B Squash, winter 0.030000 1.000 1.000 0902357001 9B Squash, winter

- babyfood 0.030000 1.000 1.000 1307359000 13G Strawberry 0.070000 1.000 1.000 1307359001 13G Strawberry

- babyfood 0.070000 1.000 1.000 1307360000 13G Strawberry, juice 0.070000 1.000 1.000 1307360001 13G Strawberry, juice

- babyfood 0.070000 1.000 1.000 9500362000 O Sugarcane, sugar 0.200000 1.000 1.000 9500362001 O Sugarcane, sugar

- babyfood 0.200000 1.000 1.000 9500363000 O Sugarcane, molasses 0.200000 1.000 1.000 9500363001 O Sugarcan e, molasses

- babyfood 0.200000 1.000 1.000 2002364000 20B Sunflower, seed 0.500000 1.000 1.000 2002365000 20B Sunflower, oil 0.500000 1.000 1.000 2002365001 20B Sunflower, oil

- babyfood 0.50 0000 1.000 1.000 0103366000 1CD Sweet potato 0.020000 1.000 1.000 0103366001 1CD Sweet potato

- babyfood 0.020000 1.000 1.000

0402367000 4B Swiss chard 0.020000 1.000 1.000

0103371000 1CD Tanier, corm 0.020000 1.000 1.000

0801374000 8A Tomatillo 0.020000 1.000 1.000

0801375000 8A Tomato 0.020000 1.000 1.000

0801375001 8A Tomato

- babyfood 0.020000 1.000 1.000 0801376000 8A Tomato, paste 0.020000 1.000 1.000 0801376001 8A Tomato, paste

- babyfood 0.020000 1.000 1.000 0801377000 8A Tomato, puree 0.020000 1.000 1.00 0 0801377001 8A Tomato, puree

- babyfood 0.020000 1.000 1.000 0801378000 8A Tomato, dried 0.020000 1.000 1.000 0801378001 8A Tomato, dried

- babyfood 0.020000 1.000 1.000 0801379000 8A Tomato, juice 0.020000 1.000 1.000

0103387000 1CD Turmeric 0.020000 1.000 1.000

1400391000 14 Walnut 0.020000 1.000 1.000 8601000000 86A Water, direct, all sources 0.400000 1.000 1.000aquati

Full comment: aquatic herbicide 8602000000 86B Water, indirect, all sources 0.400000 1.000 1.000aquati

Full comment: aquatic herbicide

0901399000 9A Watermelon 0.030000 1.000 1.000 0901400000 9A Watermelon, juice 0.030000 1.000 1.000 1500401000 15 Wheat, grain 0.400000 1.000 1.000 1500401001 15 Wheat, grain

- babyfood 0.400000 1.000 1.000 1500402000 15 Wheat, f lour 0.400000 1.000 1.000 1500402001 15 Wheat, flour

- babyfood 0.400000 1.000 1.000 1500403000 15 Wheat, germ 0.400000 1.000 1.000 1500404000 15 Wheat, bran 0.40 0000 1.000 1.000 0103406000 1CD Yam, true 0.020000 1.000 1.000

0103407000 1CD Yam bean 0.020000 1.000 1.000 0301338000 3A Shallot, bulb 0.020000 1.000 1.000

1100173500 11 Goji berry 0.020000 1.000 1.000



## A ttachment 2: Acute Results File

US EPA Ver. 3.16, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for FLUMIOXAZIN NHANES 2003

- 2008 2

- Day Residue file: FLUMIOXAZIN_ACUTE2.R08 Adjustment factor #2 NOT used. Analysis Date: 10

- 15

- 2012/11:02:50 Residue file dated: 10

- 15

- 2012/10:57:13

### Flumioxazin Dietary Exposure and Risk Assessment DP Number: 406069

PC Code: 129034

______________________________________________________ ________________________________

Page 13 of 17 NOEL (Acute) = 3.000000 mg/kg body

- wt/day RAC/FF intake summed over 24 hours

Run Comment: "Food + Drinking Water"

===============================================================================

Summary calculations

-- per capita:

--- 95th Percentile

---- --- 99th Percentile

---- --- 99.9th Percentile

---- Exposure % aRfD MOE Expo sure % aRfD MOE Exposure % aRfD MOE

---------- ------- -------- ---------- ------- -------- ---------- ------- -------- Female 13

- 49:

0.022607 75.36 132 0.033034 110.11 90 0.045900 153.00 65



## Attachment 3 : Ch ronic Food plus Water Residue Input File

US EPA Ver. 3.16, 03

- 08

- d

DEEM

- FCID Chronic analysis for FLUMIOXAZIN

Residue file: C: \ Deemfcid \ FLUMIOXAZIN_CHRONIC2.R08 Adjust. #2 used Analysis Date 08

- 31

- 2012 Residue file dated: 08

- 31

- 2012/17:39:04 Reference dose (RfD) = 0.02 mg/kg bw/day Comment:Food + Drinking Water

---------------------------------------------------------------------------------- Food Crop Residue Adj.Factors EPA Code Grp Food Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ 1400003000 14 Almond 0.020 000 1.000 1.000

1400003001 14 Almond

- babyfood 0.020000 1.000 1.000 1400004000 14 Almond, oil 0.020000 1.000 1.000 1400004001 14 Almond, oil

- babyfood 0.020000 1.00 0 1.000 1100007000 11 Apple, fruit with peel 0.020000 1.000 1.000 1100008000 11 Apple, peeled fruit 0.020000 1.000 1.000 1100008001 11 Apple, peeled fruit

- babyfood 0.020000 1.000 1.0 00 1100009000 11 Apple, dried 0.020000 8.000 1.000 1100009001 11 Apple, dried

- babyfood 0.020000 8.000 1.000 1100010000 11 Apple, juice 0.020000 1.300 1.000

1100 010001 11 Apple, juice

- babyfood 0.020000 1.300 1.000 1100011000 11 Apple, sauce 0.020000 1.000 1.000 1100011001 11 Apple, sauce

- babyfood 0.020000 1.000 1.000

1202012000 12B Apricot 0.020000 1.000 1.000 1202012001 12B Apricot

- babyfood 0.020000 1.000 1.000 1202013000 12B Apricot, dried 0.020000 6.000 1.000 1202014000 12B Apricot, juice 0.020000 1.000 1.000 1202014001 12B Apricot, juice

- babyfood 0.020000 1.000 1.000 0103015000 1CD Arrowroot, flour 0.020000 1.000 1.000 0103015001 1CD Arrowroot, flour

- b abyfood 0.020000 1.000 1.000 9500016000 O Artichoke, globe 0.060000 1.000 1.000 0103017000 1CD Artichoke, Jerusalem 0.020000 1.000 1.000 9500019000 O Asparagus 0.020000 1.000 1.000 0902021000 9B Balsam pear 0.030000 1.000 1.000 0603030000 6C Bean, black, seed 0.070000 1.000 1.000 0603032000 6C Bean, broad, seed 0.0 70000 1.000 1.000 0603034000 6C Bean, cowpea, seed 0.070000 1.000 1.000 0603035000 6C Bean, great northern, seed 0.070000 1.000 1.000 0603036000 6C Bean, kidney, seed 0.070000 1. 000 1.000 0603038000 6C Bean, lima, seed 0.070000 1.000 1.000 0603039000 6C Bean, mung, seed 0.070000 1.000 1.000 0603040000 6C Bean, navy, seed 0.070000 1.000 1 .000 0603041000 6C Bean, pink, seed 0.070000 1.000 1.000 0603042000 6C Bean, pinto, seed 0.070000 1.000 1.000 1302057000 13B Blueberry 0.020000 1.000 1.000

13 02057001 13B Blueberry

- babyfood 0.020000 1.000 1.000

### Flumioxazin Dietary Exposure and Risk Assessment DP Number: 406069

PC Code: 129034

______________________________________________________ ________________________________

Page 14 of 17 1400059000 14 Brazil nut 0.020000 1.000 1.000

1400068000 14 Butternut 0.020000 1.000 1.000

0501069000 5 A Cabbage 0.060000 1.000 1.000 0502070000 5B Cabbage, Chinese, bok choy 0.060000 1.000 1.000 0501071000 5A Cabbage, Chinese, napa 0.060000 1.000 1.000 0501072000 5A Cabbag e, Chinese, mustard 0.060000 1.000 1.000

9500073000 O Cactus 0.070000 1.000 1.000 0901075000 9A Cantaloupe 0.030000 1.000 1.000

0402076000 4B Cardoon 0.020000 1.000 1.000

1400081000 14 Cashew 0.020000 1.000 1.000

0103082000 1CD Cassava 0.020000 1.000 1.000

0103082001 1CD Cassava

- babyfood 0.020000 1.000 1.000 0402085000 4B Celery 0.020000 1.000 1.000 0402085001 4B Celery

- babyfood 0.020000 1.000 1.000 0402086000 4B Celery, juice 0 .020000 1.000 1.000

0402087000 4B Celtuce 0.020000 1.000 1.000 0902088000 9B Chayote, fruit 0.030000 1.000 1.000 1201090000 12A Cherry 0.020000 1.000 1.000 1201090001 12A Cherry

- babyfood 0.020000 1.000 1.000 1201091000 12A Cherry, juice 0.020000 1.500 1.000 1201091001 12A Cherry, juice

- babyfood 0.020000 1.500 1.000

1400092000 14 Chestnut 0.020000 1.000 1.000 0603098000 6C Chickpea, seed 0.070000 1.000 1.000 0603098001 6C Chickpea, seed

- babyfood 0.070000 1.000 1.000 0603099000 6C Chickpea, flour 0.070000 1.000 1.000 0902102000 9B Chinese waxgourd 0.030000 1.000 1.000 1500120000 15 Corn, field, flour 0.020000 1.000 1.000

1500120001 15 Corn, field, flour

- babyfood 0.020000 1.000 1.000 1500121000 15 Corn, field, meal 0.020000 1.000 1.000 1500121001 15 Corn, field, meal

- babyfood 0.020000 1.000 1.000

1500122000 15 Corn , field, bran 0.020000 1.000 1.000 1500123000 15 Corn, field, starch 0.020000 1.000 1.000 1500123001 15 Corn, field, starch

- babyfood 0.020000 1.000 1.000 1500124000 15 Corn, field, s yrup 0.020000 1.000 1.000 1500124001 15 Corn, field, syrup

- babyfood 0.020000 1.000 1.000 1500125000 15 Corn, field, oil 0.020000 1.000 1.000 1500125001 15 Corn, field, oil

- babyfoo d 0.020000 1.000 1.000 2003128000 20C Cottonseed, oil 0.020000 1.000 1.000 2003128001 20C Cottonseed, oil

- babyfood 0.020000 1.000 1.000 1100129000 11 Crabapple 0.020000 1.000 1.000

0902135000 9B Cucumber 0.030000 1.000 1.000

1302136000 13B Currant 0.020000 1.000 1.000 1302137000 13B Currant, dried 0.020000 1.000 1.000 0103139000 1CD Dasheen, corm 0.020000 1.000 1.000 0802148000 8BC Eggplant 0.020000 1.000 1.000 1302149000 13B Elderberry 0.020000 1.000 1.000 0402152000 4B Fennel, Florence 0.020000 1.000 1.000

1400155000 14 Hazelnut 0.020000 1.000 1.000 1400156000 14 Hazelnut, oil 0.020000 1.000 1.000

8000157000 80 Fish

- freshwater finfish 1.500000 1.000 1.000

8000158000 80 Fish

- freshwater finfish, farm ra 1.500000 1.000 1.000 2001163000 20A Flax seed, oil 0.400000 1.000 1.000

03011650 00 3A Garlic, bulb 0.020000 1.000 1.000 0301165001 3A Garlic, bulb

- babyfood 0.020000 1.000 1.000 0103166000 1CD Ginger 0.020000 1.000 1.000

0103166001 1CD Gi nger

- babyfood 0.020000 1.000 1.000 0103167000 1CD Ginger, dried 0.020000 1.000 1.000 1302174000 13B Gooseberry 0.020000 1.000 1.000 1304175000 13D Grape 0.020000 1.000 1.000 1304176000 13D Grape, juice 0.020000 1.200 1.000 1304176001 13D Grape, juice

- babyfood 0.020000 1.200 1.000 9500177000 O Grape, leaves 0.020000 1.000 1.000 9500178000 O Grape, raisin 0.020000 4.300 1.000 1304179000 13D Grape, wine and sherry 0.020000 1.000 1.000 0603182000 6C Guar, seed 0.070000 1.000 1.000 0603182001 6C Guar, seed

- babyfood 0.070000 1.000 1.000

### Flumioxazin Dietary Exposure and Risk Assessment DP Number: 406069

PC Code: 129034

______________________________________________________ ________________________________

Page 15 of 17 1400185000 14 Hickory nut 0.020000 1.000 1.000 0901187000 9A Honeydew melon 0.03000 0 1.000 1.000 9500188000 O Hop 0.050000 1.000 1.000 1302191000 13B Huckleberry 0.020000 1.000 1.000 0603203000 6C Lentil, seed 0.070000 1.000 1.000 1100210000 11 Loquat 0.020000 1.000 1.000

1400213000 14 Macadamia nut 0.020000 1.000 1.000

1202230000 12B Nectarine 0.020000 1.000 1.000

0802234000 8BC Okra 0.020000 1.000 1.000

9500235000 O Olive 0.060000 1.000 1.000 9500236000 O Olive, oil 0.060000 1.000 1.000

030123 7000 3A Onion, bulb 0.020000 1.000 1.000 0301237001 3A Onion, bulb

- babyfood 0.020000 1.000 1.000 0301238000 3A Onion, bulb, dried 0.020000 9.000 1.000

0301238001 3A Onion, bulb, dried

- babyfood 0.020000 9.000 1.000 0603256000 6C Pea, dry 0.070000 1.000 1.000 0603256001 6C Pea, dry

- babyfood 0.070000 1.000 1.000 0603258000 6C Pea, pigeo n, seed 0.070000 1.000 1.000

1202260000 12B Peach 0.020000 1.000 1.000

1202260001 12B Peach

- babyfood 0.020000 1.000 1.000 1202261000 12B Peach, dried 0.020000 7.000 1.000 1202261001 12B Peach, dried

- babyfood 0.020000 7.000 1.000 1202262000 12B Peach, juice 0.020000 1.500 1.000 1202262001 12B Peach, juice

- babyfood 0.020000 1.500 1.000

9500263000 O Peanut 0.020000 1.000 1.000 9500264000 O Peanut, butter 0.020000 1.890 1.000 9500265000 O Peanut, oil 0.020 000 1.000 1.000

1100266000 11 Pear 0.020000 1.000 1.000

1100266001 11 Pear

- babyfood 0.020000 1.000 1.000 1100267000 11 Pear, dried 0.020000 6.25 0 1.000 1100268000 11 Pear, juice 0.020000 1.000 1.000 1100268001 11 Pear, juice

- babyfood 0.020000 1.000 1.000

1400269000 14 Pecan 0.020000 1.000 1.0 00 0802270000 8B Pepper, bell 0.020000 1.000 1.000 0802270001 8B Pepper, bell

- babyfood 0.020000 1.000 1.000 0802271000 8B Pepper, bell, dried 0.020000 1.000 1.000

0802 271001 8B Pepper, bell, dried

- babyfood 0.020000 1.000 1.000 0802272000 8BC Pepper, nonbell 0.020000 1.000 1.000 0802272001 8BC Pepper, nonbell

- babyfood 0.020000 1.000 1.000

0802273000 8BC Pepper, nonbell, dried 0.020000 1.000 1.000 9500275000 O Peppermint 0.040000 1.000 1.000 9500276000 O Peppermint, oil 0.040000 1.000 1.000

1400282000 14 Pistachi o 0.020000 1.000 1.000

1203285000 12C Plum 0.020000 1.000 1.000

1203285001 12C Plum

- babyfood 0.020000 1.000 1.000 1203286000 12C Plum, prune, fresh 0.020000 1.000 1.000 1203286001 12C Plum, prune, fresh

- babyfood 0.020000 1.000 1.000 1203287000 12C Plum, prune, dried 0.020000 5.000 1.000 1203287001 12C Plum, prune, dried

- babyfood 0.020000 5.000 1.000 1203288000 12C Plum, prune, juice 0.020000 1.400 1.000 1203288001 12C Plum, prune, juice

- babyfood 0.020000 1.400 1.000 9500289000 O Pomegranate 0.0 60000 1.000 1.000 0103296000 1C Potato, chips 0.020000 1.000 1.000 0103297000 1C Potato, dry (granules/ flakes) 0.020000 6.500 1.000 0103297001 1C Potato, dry (granules/ flakes)

- b 0.020000 6. 500 1.000 0103298000 1C Potato, flour 0.020000 1.000 1.000 0103298001 1C Potato, flour

- babyfood 0.020000 1.000 1.000 0103299000 1C Potato, tuber, w/peel 0.020000 1.000 1 .000 0103299001 1C Potato, tuber, w/peel

- babyfood 0.020000 1.000 1.000 0103300000 1C Potato, tuber, w/o peel 0.020000 1.000 1.000 0103300001 1C Potato, tuber, w/o peel

- babyfood 0.020000 1.000 1.000

09 02308000 9B Pumpkin 0.030000 1.000 1.000 0902309000 9B Pumpkin, seed 0.030000 1.000 1.000 1100310000 11 Quince 0.020000 1.000 1.000

2001319000 2 0A Rapeseed, oil 0.400000 1.000 1.000 2001319001 20A Rapeseed, oil

- babyfood 0.400000 1.000 1.000

### Flumioxazin Dietary Exposure and Risk Assessment DP Number: 406069

PC Code: 129034

______________________________________________________ ________________________________

Page 16 of 17 0402322000 4B Rhubarb 0.020000 1.000 1.000

2002330000 20B Safflo wer, oil 0.500000 1.000 1.000 2002330001 20B Safflower, oil

- babyfood 0.500000 1.000 1.000 0600347000 6 Soybean, seed 0.020000 1.000 1.000 0603348000 6C Soybean, flour 0.020000 1.000 1.000 0603348001 6C Soybean, flour

- babyfood 0.020000 1.000 1.000 0600349000 6 Soybean, soy milk 0.020000 1.000 1.000 0600349001 6 Soybean, soy milk

- babyfood or in 0.020000 1.000 1.000 0600350000 6 Soybean, oil 0.020000 1.000 1.000 0600350001 6 Soybean, oil

- babyfood 0.020000 1.000 1.000 9500352000 O Spearmint 0 .040000 1.000 1.000 9500353000 O Spearmint, oil 0.040000 1.000 1.000 0902356000 9B Squash, summer 0.030000 1.000 1.000 0902356001 9B Squash, summer

- babyfood 0.030000 1.000 1.000 0902357000 9B Squash, winter 0.030000 1.000 1.000 0902357001 9B Squash, winter

- babyfood 0.030000 1.000 1.000 1307359000 13G Strawberry 0.070000 1.000 1.000 1307359001 13G Strawberry

- babyfood 0.070000 1.000 1.000 1307360000 13G Strawberry, juice 0.070000 1.000 1.000 1307360001 13G Strawberry, juice

- babyfood 0.070000 1.000 1.000 9500362000 O Sugarcane, sugar 0.200000 1.000 1.000 9500362001 O Sugarcane, sugar

- babyfood 0.200000 1.000 1.000 9500363000 O Sugarcane, molasses 0.200000 1.000 1.000

9500363001 O Sugarcane, molasses

- babyfood 0.200000 1.000 1.000 2002364000 20B Sunflower, seed 0.500000 1.000 1.000 2002365000 20B Sunflower, oil 0.500000 1.000 1.000

2002365001 20B Sunf lower, oil

- babyfood 0.500000 1.000 1.000 0103366000 1CD Sweet potato 0.020000 1.000 1.000 0103366001 1CD Sweet potato

- babyfood 0.020000 1.000 1.000

0402367000 4B Swiss chard 0.020000 1.000 1.000 0103371000 1CD Tanier, corm 0.020000 1.000 1.000

0801374000 8A Tomatillo 0.020000 1.000 1.000

0801375000 8A Tomato 0.020000 1.000 1.000

0801375001 8A Tomato

- babyfood 0.020000 1.000 1.000 0801376000 8A Tomato, paste 0.020000 1.000 1.000 0801376001 8A Tomato, paste

- babyfood 0.020000 1.000 1.000 0801377000 8A Tomato, puree 0.020000 1.000 1.000 0801377001 8A Tomato, puree

- babyfood 0.020000 1.000 1.000 0801378000 8A Tomato, dried 0.020000 1.000 1.000 0801378001 8A Tomato, dried

- babyfood 0.020000 1.000 1.000 0801379000 8A Tomato, juice 0.020000 1.000 1.000

0103387000 1CD Turmeric 0.020000 1.000 1.000

1400391000 14 Walnut 0.020000 1.000 1.000 8601000000 86A Water, direct, all sources 0.142000 1.000 1.000 8602000000 86B Water, indirect, all sources 0.142000 1.000 1.000

0901399000 9A Watermelon 0.030000 1.000 1.000 0901400000 9A Watermelon, juice 0.030000 1.000 1.000 1500401000 15 Wheat, grain 0.400000 1.000 1.000

15004010 01 15 Wheat, grain

- babyfood 0.400000 1.000 1.000 1500402000 15 Wheat, flour 0.400000 1.000 1.000 1500402001 15 Wheat, flour

- babyfood 0.400000 1.000 1.000

1500403000 15 Wh eat, germ 0.400000 1.000 1.000 1500404000 15 Wheat, bran 0.400000 1.000 1.000 0103406000 1CD Yam, true 0.020000 1.000 1.000

0103407000 1CD Yam bean 0.020000 1.000 1.000 0301338000 3A Shallot, bulb 0.020000 1.000 1.000 1100173500 11 Goji berry 0.020000 1.000 1.000



## A ttachment 4 : Chronic Results Fil e

### Flumioxazin Dietary Exposure and Risk Assessment DP Number: 406069

PC Code: 129034

______________________________________________________ ________________________________

Page 17 of 17 US EPA Ver. 3.16, 03

- 08

- d

DEEM

- FCID Chronic analysis for FLUMIOXAZIN NHANES 2003

- 2008 2

- day

Residue file name: C: \ Deemfcid \ FLUMIOXAZIN_CHRONIC.R08 Adjustment factor #2 NOT used. Analysis Date 10

- 15

- 2012/11:22:21 Residue file dated: 10

- 15

- 2012/11:19:15 Reference dose (RfD, Chronic) = .02 mg/kg bw/day COMMENT 1: Food + Drinking Water

=============================================== ================================ Total exposure by population subgroup

-------------------------------------------------------------------------------

Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- - ------------ ---------------- Total US Population 0.003932 19.7% Hispanic 0.003804 19.0%

Non

- Hisp

- White 0.004018 20.1 %

Non

- Hisp

- Black 0.003371 16.9%

Non

- Hisp

- Other 0.004465 22.3% Nursing Infants 0.003246 16.2%

Non

- Nursing Infants 0.011213 56.1%

Female 13+ PREG 0.003582 17.9%

Children 1

- 6 0.006199 31.0%

Children 7

- 12 0.004024 20.1%

Male 13

- 19 0.003069 15.3%

Female 13

- 19/NP 0.003164 15.8%

Male 20+ 0.003539 17.7% Female 20+/NP 0.003812 19.1%

Seniors 55+ 0.003567 17.8%

All Infants 0.008753 43.8%

Female 13

- 50 0.003692 18.5%

Children 1

- 2 0.006811 34.1%

Children 3

- 5 0.005959 29.8%

Children 6

- 12 0.004253 21.3%

Youth 13

- 19 0.003116 15.6%

Adults 20

- 49 0.003715 18.6%

Adults 50

- 99 0.003633 18.2%

Female 13

- 49 0.003692 18.5%

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