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### UNITED STATES ENVIRONMENTAL PROTECTION AGENCY **WASHINGTON, D.C. 20460 OFFICE OF CHEMICAL SAFETY**  **AND POLLUTION PREVENTION** 

### MEMORANDUM DATE: 04/ 17 /2013 SUBJECT: **Pyraclostrobin.** Acute and Chronic Aggregate Dietary (Food and Drinking

Water) E xpos ure and Risk Assessments to Support New Use s on Sugarcane, Persimmon, Globe Artichoke, and Belgium Endive PC Code: 099100 DP Barcode: 410739 Decision No.: 465126; Registration No. : 7969 - 185; 7969 - 186; 7969 - 247; 7969 - 258; 7969 - 289; 7969 - 291 Petition No.: 2F8038 Regulatory Action: Section 3 Registration Risk Assessment T ype: Single chemical/aggregate Case No.: None T XR No.: None CAS No.: 175013 - 18 - 0 MRID No.:48237401 40 CFR: 180.582 FROM: Stephen Funk, Senior Chemist

Risk Assessment Branch III Health Effects Division (7509P) THROUGH: Nancy Dodd, Chemist

Mohsen Sahafeyan, Chemist Dietary Exposure Science Advisory Council (DESAC) Health Effects Division (7509P) And Christine Olinger, Branch Chief Risk Assessment Branch III Health Effects Division (7509P) **TO:** Tony Kish/ Dominic Schuler, Team #22

Fungicide Branch Registration Division (7505P) Barry O’Keefe, Risk Assessor Risk Assessment Branch III Health Effects Division (7509P )Py

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### Executive Summary Acute and chronic dietary (food and drinking water) exposure and risk assessments were conducted using the Dietary Exposure Evaluation M odel software with the Food Commodity Intake Database (DEEM - FCID ) , Version 3.16 . This software use s 2003

– 2008 food consumption data from the U.S. Department of Agriculture’s (USDA’s) National Health and Nutrition Examination Survey , What We Eat in America (NHANES/WWEIA). The anal ys es were conducted in support of a human - health risk assessment for the proposed Section 3 uses of py raclostrobin on sugar cane, persimmon, Belgium endive, and globe artichoke . This memorandum was reviewed b y two peer reviewers of the DESAC per the DESAC SOP. The last dietary

risk assessment for py

raclostrobin was performed in 2009 (DP Barcode #369379 , W. Cutchin) to support a new use on alfalfa. That assessment has been updated b y new estimated per cent crop treated data from BEAD (11/08/2012) , by new drinking water concentration level estimates from BEAD (02/13/2013) , and b y the addition of new comm odities (globe artic hoke, Belgium endive, persimmon). Acute Dietary

(Food and Drinking Water) Exposure Results and Characterization A slightly refined acute dietary

exposure assessment was perfo r med for p yr aclostrobin. The anal ys is used tolerance - le vel residues or highest field trial residues , 100% crop treated , and empirical or default processing factors. Experimentally derived processing factors were used for fruit juices , tomato , sugarcane, and wheat commodities . For all other processed commodities, DEEM default processing factors were assumed. Estimated drinking water concentrations (EDWCs) were also used . The estimated acute drinking water concentration for p yraclostrobin ( 0.0356 ppm) was calculated based on a turf scenario for surface water . The results of the acute dietary anal ys is for food and drinking water indicate that acute dietary risks do not exceed the Agency ’s level of concern ( < 100% of the aPAD) for the U.S. population and all subgroups. Combined dietary exposure from food an d drinking water at the 95 th 

### percentile of exposure for the U.S. population is equivalent to 1.5 % of the acute Population Adjusted Dose (aPAD). The population subgroup with the highest estimated acute dietary exposure to py

raclostrobin is females 13 - 49 ye ars , with an estimated exposure at the 95 th 

### percentile of 8 7 % of the aPAD. Chronic Dietary (Food and Drinking Water) Exposure Results and Characterization A refined chronic dietary anal ys is was conducted for this assessment in order to compensate for exp osure resulting from residential uses in the aggregate assessment. The chronic dietary anal ys is included tolerance - level or average field trial residues , average percent crop treated estimate s (20 12 ) when available , and empirical processing factors. Scre ening level estimates of agricultural uses of p yr aclostrobin w ere provided previously by the Biological & Economic Analy sis Division (BEAD). E xperimentally derived processing fa ctor s were used for fruit juices, tomato , sugar cane, and wheat commodities . For all other processed commodities, DEEMPy

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### default processing factors were assumed. The estimated drinking water concentration for py raclostrobin ( 0.0023 ppm) was calculated based on a turf scenario for surface water. The results of the refined chronic dietary (food and drinking water) anal ys is are below the Agency ’s level of concern for all population subgroups . The dietary exposure for food and drinking water for the general U.S. population is 8. 0 % of the chronic Population Adjusted Dose (c PAD ) and 2 7 % of the cPAD for children 1 - 2 y rs , the population subgroup with the highest estimated chronic dietary exposure to py raclostrobin. Cancer Dietary

Exposure Results and Characterization The Cancer Assessment Review Committee ( CARC ) concluded that the py rac lostrobin is “not likely to be carcinogenic to humans . ” Therefore, a cancer dietary exposure assessment was not conducted. **I. Introduction**  Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute and chronic assess ments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). This dose is referred to as the population adjusted dose (PAD). The PAD is equivalent to the point of d eparture ( PO D , NOAEL, LOAEL ) divided by the required uncertainty or s afety f actor s . For acute and non - cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD. References which discuss the acute an d chronic risk assessments in more detail are available on the EPA/pesticides web site: “Available Information on Assessing Exposure from Pesticides, A User’s Guide,” 6/21/2000, web link: http://www.epa.gov/fedrgstr/EPA - PEST/2000/July /Day- 12/6061.pdf ; or see SOP 99.6 (8/20/99). The most recent dietary risk assessment for p yraclostrobin was conducted by W. Cutchin (D369379, 10/30/2009) to support a new use on alfalfa. **II. Residue Information**  Py raclostrobin belongs to the strobilurin class of fungicides. Strobilurins are s ynthetic analogs of a natural antifungal substance which inhibits spore germination, mycelial growth, and sporulation of the fungus on the leaf surface. Py raclostrobin tolerances have been established in 40 CFR §180.582. Tolerances for plant commodities are listed in 40 CFR §180.582 (a)(1) for residues of the fungicide py raclostrobin , including its metabolites and degradates. Complinace with the tolerance levels is to be determined by measuring onl y the sum of pyraclostrobin (carbamic acid, [2 - [[[1 - (4 - chlorophenyl ) - 1 H - py razol - 3 - yl ]oxy]methyl]phenyl]methoxy- , methyl ester) and its desmethox y metabolite , methyl 2 - [[[1 - (4 - chlorophenyl) - 1 H - py razol - 3 - yl ]ox y] methyl]phenyl carbamate, calculated as the stoichiometric equivalent of py raclostrobin.Py

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### The HED Metabolism Assessment Review Committee (MARC memo of 10/9/01, DP# 278044, L. Cheng) determined that for purposes of tolerance and dietary risk assessments, the residues of concern in plant and rotational crop commodities include p yraclostrobin and the desmethox y metabolite. The residues of concern in livestock commodities include py raclostrobin and its metabolites convertible to 1 - (4 - chlorophenyl) - 1 H - py razol - 3 - ol and 1 - (4 - chloro - 2 - hydrox yphenyl ) - 1 H

- py razol - 3 - ol. The USDA Pesticide Data Program (PDP) monitored pesticide residues in catfish in 2008, 2009, and 2010. Over this 3 - ye ar period, PDP anal yz ed 1479 samples of catfish for py raclostrobin residues. Non e of the samples contained detectable residues (lod about 0.0 15 ppm) . As a result, residues in fish were not included in the assessment. The potential for secondary transfer of py

raclostrobin residues of concern in meat, milk, poultry , and eggs exists b ecause there are several livestock feedstuffs that are associated with the existing uses. The proposed uses do not add to the potential for transfer, as the new commodities do not include livestock feed items of regulatory interest. A summary

of the proposed and recommended tolerances for the new uses are listed in Table 1. Table 1. Tolerance Summary for P yraclostrobin for New Uses Commodity Proposed Tolerance (ppm) Recommended Tolerance (ppm) Artichoke, globe 3.0 3.0 Endive, Belgium 3.0 4.0 Persi mmon 3.0 3.0 Sugarcane, cane 0.2 0.2 Py raclostrobin and the desmethoxy metabolite were determined separatel y in the field trial samples, and the combined residue was calculated as py raclostrobin. Residue Data used for Acute and Chronic Assessments: Fo r the acute dietary

analy sis, tolerance or highest average field trial residues (HAFT) and one hundred percent crop treated was assumed for all commodities . For the refined chronic dietary analy sis, average field trial residues were calculated for certai n crops ( coffee, sorghum grain, stone fruits crop group 12, apple, broccoli, celery , collard, grape, lettuce, citrus, pepper, mustard green , and tomato ) , which are the major dietary contributors based on preliminary

run s . Average field trial values were u sed for the new commodities persimmon, Belgium endive, sugarcane, and globe artichoke. Field trial data were translated from the representative commodities to the non - representative commodities according to HED SOP 2000.1:”Guidance for Translation of Fiel d Trial Data from Representative Commodities in the Crop Group Regulation to other Commodities in Each Crop Group/Subgroup.” Residue values used for acute and chronic assessments for some of the existing and proposed uses are listed in Table 2. For thos e not listed, tolerance level residues were used.Py

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Page **5** of **34 Table 2. Residue Data used for Acute and Chronic Dietary Risk Assessments.**  **Comm odity**  **Acute (Tolerance, Highest Field Trial Residues, HR** 

**(ppm) Chronic (Average Residues,**  **AR (ppm)** Amaranth, leafy HR ( 23.38) AR (11.77) Arugula HR (23.38) AR (11.77) Chrysanthemum HR (23.38) AR (11.77) Cress, garden HR (23.38) AR (11.77) Cress, upland HR (23.38) AR (11.77) Dandelion, leaves HR (23.38) AR (11.77) Fennel HR (23.38) AR (5.02) Parsley, leaves HR (23.38 ) AR (11.77) Radicchio HR (23.38) AR (0.59) Rhubarb HR (23.38) AR (5.02) Spinach HR (23.38) AR (11.77) Swiss chard HR (23.38) AR (5.02) Apple Tol (1.5) AR (0.31) Beans, dry HR (0.21) Tol (0.5) Broccoli Tol (5.0) AR (1.10) Celery HR (10.7) AR (5.02) Chickpea, seed HR (0.34) HR (0.34) Collards Tol (16.0) AR (5.74) Grape Tol (2.0) AR (0.768) Guar, seed HR (0.34) Tol (0.5) Lettuce, head HR (14.4) AR (0.59) Lettuce, leaf HR (20.1) AR (7.68) Mustard greens Tol (16.0) AR (5.74) Orange Tol (2.0) AR (0.3) Pea, dry HR (0.1) Tol (0.5) Tomato Tol (1.4) AR (0.158) Apricot Tol (2.5) AR (0.602) Cherry (sweet & sour) Tol (2.5) AR (0.846) Nectarine Tol (2.5) AR (0.602) Peach Tol (2.5) AR (0.602) Plum Tol (2.5) AR (0.198) Coffee Tol (0.3) AR (0.064) Sorghum, grain Tol (0.6) AR (0.09) Artichoke, globe Tol (3.0) AR (0.84) Endive, Belgium Tol (4.0) AR (0.82) Persimmon Tol (3.0) AR (0.60) Sugarcane, cane Tol (0.2) AR (0.076) 

### The anal ys is includes HED - recommended tolerance level residue values for the herb subgroup 19A, although these tolerances were never finalized. The tolerances were recommended in connection with PP# 6E716 5 (D3 43754 , J. Stokes, 02 / 12 /200 8 ).Py

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### Experimentally

derived processing factors for s everal commodities were applied. For all other processed commodities, DEEM (ver. 7.81) default processing factors were assumed. See Table 3. **Table 3. Processing Factors for Pyraclostrobin Dietary Risk**

**Assessment. Comm**  **odity PF**  Apple, juice 0.2 Apple, juice - babyfood 0.2 Beet, sugar 0.4 Beet, sugar - babyfood 0.4 Beet, sugar, molasses 0.4 Beet, sugar, molasses - babyfood 0.4 Corn, field, syrup 1.5 Flaxseed, oil 1.2 Grape, juice 0.01 Grape, juice - babyfood 0.01 Grapefruit, juice 0.02 Grape - raisins 1.0 Lemon, juice 0.02 Lemon, juice - babyfood 0.02 Lime, juice 0.02 Lime, juice - babyfood 0.02 Orange, juice 0.02 Orange, juice - babyfood 0.02 Peach, dried 7.0 Plums

– prunes dried 1.3 Plums - prunes dried - babyfo od 1.3 Potato, dry (granules/ flakes) 6.5 1 Potato, dry (granules/ flakes) - babyfood 6.5 1 Potato, flour 6.5 1 Potato, flour - babyfood 6.5 1 Sugarcane, sugar 0.15 Sugrcane, molasses 0.15 Tangerine, juice 0.02 Tomato, paste 2.1 Tomato, puree 0.55 Wheat (Triticale), flour 0.7 Wheat (Triticale), flour - babyfood 0.7 Wheat , germ 0.85 1 Factor reduced to 1 based on use of tolerance for potato. 

### BEAD has provided updated percent crop treated information for p yr aclostrobin ( S. Haddad, 11/18/2012 ). For the chronic anal ys es, the weighted average %CT was incorporated , which i sPy

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### listed as Adjustment Factor 2 in the DEEM - FCID R98 file . One hundred percent crop treated was assumed for commodities with no % CT information . The following average percent crop treated estimates were used in the chronic dietary risk assessments for the crops that are currentl y registered for p yr aclostrobin: almonds 40%; apples 15%; apricots 25%; barley 10%; green beans 5%; blueberries 45%; broccoli 5%; cabbage 10 % ; c an eberries 50%; cantaloupes 15%; carrots 35%; cauliflower <2.5%; celery <2.5% ; cherries 50%; corn 10%; cotton <2.5%; cucumber 5%; dry beans/peas 10%; garlic 1 5 %; grapefruit 25%; grapes 30%; hazelnuts (filberts) 15%; lemons <2.5%; lettuce 5%; nectarines 10%; onions 20 % ; oranges 5%; peaches 20%; peanuts 25%; pears 15%; green peas 5 %; pecans <2.5%; peppers 10%; pi stachios 30 % ; plums/prunes 5%; potatoes 15%; pumpkins 20%; rice <1%; so ybeans 5% ; spinach 5%; squash 15%; strawberries 65%; sugar beets 45%; sugarcane 5%; sweet corn 5%; tangelos 15%; tangerines 10%; tomatoes 2 5%; walnuts <1%; watermelons 30% ; wheat 5%. Note that the sugarcane estimate is from a time limited Section 18 and not the proposed Section 3 registration. Therefore, 100% crop treated was used for sugarcane. **IV Drinking Water Data**  The drinking water residues used in the dietary risk assessment were provided by the Environmental Fate and Effects Division ( EFED; D403871, D405066, F. Khan, 02/13/2013 , Addendum 04/ 04 /2013 ) and incorporated directly into this dietary assessment. Water residues were incorporated in the DE EM - FCID into the food categories “water, direct, all sources” and “w ater, indirect, all sources.” For surface water, the estimated drinking water concentrations ( EDWCs ) were generated using EFED’s standard suite of models. Pesticide Root Zone Model (PRZM v3.12.2, May 12, 2005) and Exposure Anal ys is Modeling S ys tem (EXAMS v2.98.04.06, Apr. 25, 2005) are simulation models coupled with the input shell PRZM/EXAMS (PE v5.0, Nov. 15, 2006) to generate EDWCs of py

raclostrobin residues that may occur in surface w ater for drinking water. For ground water, Screening Concentration in Ground Water (SCI - GROW v2.3, Jul. 29, 2003) is a regression model used as a screening tool to estimate pesticide concentrations found in ground water used as drinking water. The propos ed use of py

raclostrobin in fruiting vegetables resulted in the highest surface water concentrations of at 16.6 μg/L for 1 - 10 year peak value from ground application and 1 - 10 annual ye ar average of 1.1 μg/L from aerial application. The acute and chronic ED WCs resulting from the proposed application uses are lower than the EDWCs for surface water in the previously recommended drinking water assessments for p yraclostrobin for turf uses (USEPA 2007 D389729+ ) . Since the EDWCs for s urface water for proposed uses are lower than the previously recommended EDWCs for this chemical, the EDWCs for surface water will not supersede the EDWCs previously

recommended for turf use. N ote that a proposed use on cranberries was withdrawn by IR - 4 and that this withdrawn use would have resulted in a substantially higher EDWC (30X) for the annual average. The turf use is the same evaluation provided previously by EFED and originall y used in a 2007 assessment (D389729, 9/6/2007). All proposed new uses were considered.Py

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### Table 4 provides a summary of the estimated concentrations of py raclostrobin in surface water. In the acute anal ys is, the 1 - in - 10 year peak surface water value of 35.6 ppb was used and in the chronic analy sis the surface water value of 2.3 ppb was used. Estimates of p yr aclostrobin concentration in drinking water were less for groundwater sources . The models and their descriptions are available at the EPA internet site: http://www .epa.gov/oppefed1/models/water/ . **Table 4. EDWCs of Pyraclostrobin Crop Scenario**  **PRZ M/EXAMS Estim**  **ated Concentrations in Surface Water (**  **g/L) Acute**  **1 (μg/L)**  **Chronic (μg/L)** Surface Water NJ Nursery (no irrigation) Turf 35.6 2.3 Groundwater2 N/A 0.02 0.02 1 These are the highest EDWCs for previously evaluated use scenarios and the estimated acute and annual average surface water concentrations were 35.6 and 2.3 μg/L respectively. Previously estimated groundwater concentrations for acute was 0. 02 μg/L 2007, D389729 . 2 EDWCs based on PRZM - GW model



### . **V .**  **DEEM -**  **FCIDTM Program and Consumption Information** Py raclostrobin acute and chronic dietary exposure assessments were conducted using the DEEM FCID, Version 3.16, which incorporates 2003 - 2008 consumption data from USDA’s NHANES/WWEIA. The data are based o n the reported consumption of more than 20,000 individuals over two non - consecutive survey day s. Foods “as consumed” (e.g., apple pie) are linked to EPA - defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - c ooked; fresh or N/S, baked) using publicl y available recipe translation files developed jointly

by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups. However, f or acute exposure assessment, consumption data are retained as individual consumption events. Based on anal ys is of the 2003 - 2008 WWEIA consumption data, which took into account dietary patterns and survey

respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1 - 2, children 3 - 5, children 6 - 12, youth 13 - 19, adults 20 - 49, females 13 - 49, and adults 50 - 99 ye ars old. For a chronic dietary

expo sure assessment, an estimate of the residue level in each food or food form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average dail y consumption estimate for that food/food form to produce a residue intake estima te. The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg bo dy weight/day

and as a percent of the cPAD. This procedure is performed for each population subgroup. For an acute exposure assessment, individual one - day food consumption data are used on an individual - by- individual basis. The reported consumption amounts of each food item can be multiplied by

a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or “matched” in multiple random pairings with residue valuesPy

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### and then summed in a probabilistic assessment. The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., onl y those who reported eating relevant commodities/food forms) and a per- capita (i.e., those who reported eating the relevant commoditie s as well as those who did not) basis. In accordance with HED policy, per capita exposure and risk are reported for anal ys es performed at all levels of refinement. However, for deterministic assessments, any significant differences in user vs. per capita exposure and risk are specificall y identified and noted in the risk assessment. **V I**  **. Toxicological Information**  The toxicity

endpoints pertinent for human risk assessment are summarized in Table 5 . **Table 5. Summary of Toxicological Doses and Endpoints for Pyraclostrobin for Use in Dietary Hum**  **an Health Risk Assessments.**  **Exposure/ Scenario**  **Point of**

**Departure Uncertainty/** 

**FQPA Safety Factors**  **RfD, PAD, Level**

**of Concern for Risk Assessment**  **Study and Toxicological Effects** Ac ute Dietary (General Populatio n, including Infants and Children) NOAEL =

300 mg/kg/day UF A= 10x

UF H = 10x FQPA SF= 1x Ac ute RfD = 3.0

mg/kg/day **aPAD = 3.0** mg/kg/day Rat Acute Oral Neurotoxicity

LOAEL = 1000 mg/kg/day based on decreased body weight gain in males. Ac ute Dietary (Females 13 - 49 years of age) NOAEL= 5.0

mg/kg/day UF A= 10x

UF H = 10x FQPA SF= 1x Ac ute RfD = 0.05

mg/kg/day **aPAD = 0.05** mg/kg/day Rabbit Prenatal Developmental

Toxicity LOAEL = 10.0 mg/kg/day based on developmental toxicity findings of incr eased resorptions. Chronic Dietary (All Populations) NOAEL= 3.4

mg/kg/day UF A= 10x

UF H = 10x FQPA SF= 1x Chronic RfD =

0.034 mg/kg/day **cPAD = 0.034** mg/kg/day Rat Oral Carcinogenicity

LOAEL = 9.2 mg/kg/day based on decreased body wei ght/body weight gain, kidney tubular casts and atrophy in both sexes; increased incidence of liver necrosis and erosion/ulceration of the glandular - stomach and fore stomach in males. Cancer (oral) Classification: “Not likely to be Carcinogenic to Humans” based on the absence of significant

tumor increases in two adequate rodent carcinogenicity studies. . NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UF A = extrapolation from animal to human (int er species). UF H = potential variation in sensitivity among members of the human population (intra species). UF L = use of a LOAEL to extrapolate a NOAEL. FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic). RfD = reference dose. 

### V**I I.**  **Results/Discussion** As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the PAD. The DEEM - FCIDTM anal ys es estimate the dietary exposure of the U.S.Py

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### population and various po pulation subgroups. The results reported in Table 6 and 7 are for the general U.S. Population, all infants (<1 ye ar old), children 1 - 2, children 3 - 5, children 6 - 12, youth 13 - 19, females 13 - 49, adults 20 - 49, and adults 50 - 99 ye ars. Results of Acute Diet ary (Food and Drinking Water) Exposure Anal ys is The results of the acute dietary anal ys is for food and drinking water indicate that acute dietary risks do not exceed the Agency ’s level of concern at the 95 th 

### percentile ( < 100% of the aPAD) for the U.S. p opulation and all subgroups. At the 95 th 

### percentile, the U.S. population has an exposure from food and drinking water that results in a risk estimate for the general U.S. population of 1.5 % of the aPAD . The most highly exposed subpopulation is “ females 13 - 49 ye ars ” at 8 7 % of the aPAD. Results of Chronic Dietary (Food and Drinking Water) Exposure Analy sis The results of the aggregate chronic dietary anal ysis for food and drinking water are below the Agency ’s level of concern (<100% cPAD) for the general U.S. population ( 8. 0 % cPAD) and all population subgroups. The most highly exposed population subgroup is children 1 - 2 y rs at 2 7 % of the cPAD. The results of the acute and chronic dietary exposure anal ys e s are reported in Table 6 below. **Table 6 .**  **Summ ary of Dietary Exposure and Risk for**  **Pyraclostrobin Food**  **& Drinking Water.**

Population Subgroup Ac ute Dietary (95 th Percentile) Chronic Dietary Cancer Dietary Exposure (mg/kg/day) %

aPAD Dietary

Exposure (mg/kg/day) %

cPAD Dietary

Exposure (mg/kg/day) Ri sk General U.S. Population 0.04 4721 1.5 0.002 707 8.0

A separate quantitative cancer risk assessment is not required. All Infants (< 1 year old) 0.06 1716 2. 1 0.004353 13 Children 1 - 2 years old 0.08 3049 2.8 **0.009206 27**  Children 3 - 5 years old 0.074666 2.5 0.006204 18 Children 6 - 12 years old 0.044 25 1 1.5 0.003525 10 Youth 13 - 19 years old 0.031506 1.0 0.0 0 1832 5.4 Adults 20 - 49 years old 0.04 1 724 1.4 0.002 224 6.5 Adults 50 - 99 years old 0.04 1722 1.4 0.002252 6.6 Females 13 - 49 years old **0.04 3481**  **8 7**  0.00 2 005 5.9 *T he subpopulations with the highest risk estimates are bolded. 

### Cancer Dietary

Exposure Results and CharacterizationPy

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### As noted above, the HED CARC revisited the cancer classification for p yraclostrobin. HED has reclassified p yr aclostrobi n as “not likely to be carcinogenic to humans . " Therefore, a cancer dietary exposure anal ys is was not conducted. **IX .**  **Characterization of Inputs/Outputs** In the course of conducting a refined dietary exposure anal ys is, decisions are made regarding the fo llowing: the residue data used in the anal ys is (e.g., field trials, monitoring data, etc.), refinements incorporated in the anal ys is (such as percent crop treated and processing factors), and a variety

of other issues which may be chemical - or crop - specif ic. The acute and chronic dietary risk assessments are considered only minimally

refined. For this assessment, tolerance - level residues and field trial residue data were incorporated in the dietary anal ys es. The use of field trial data in the assessment is unlikely to underestimate actual exposure because field trial data reflects conservative pesticide residues at the minimum pre harvest interval and the maximum application rate permitted on the proposed or existing labels. Further refine ments could h ave been carried out with the use of field trial residue data in those instances where tolerance level residue values were utilized. One hundred percent crop treated was assumed for the acute anal ys is . The chronic assessment utilized average %CT estimate s when available. Further refinements could have been carried out if additional %CT estimates were used. A limited number of experimentall y derived processing factors were used to refine the acute and chronic anal ys e s . Default DEEM processing facto rs were incorporated for all other processed commodities. The inclusion of additional empirical processing factors could also refine the dietary assessment. Estimated drinking water concentrations for surface water were also incorporated . The contributio n of residues in drinking water to the dietary risk is minimal . **IX. Conclusions**  Dietary risks for py

raclostrobin are below HED’s level of concern for dietary exposure and risk. Females 13 - 49 years old are the most highly exposed popul ation subgroup for acute exposure, with risks estimates at 8 7 % of the aPAD at the 95 th 

### percentile of exposure . Children 1 - 2 ye ars old are the most highl y exposed popul ation subgroup for chronic exposure, with risks estimates at 2 7 % of the cPAD. Risks were lower for all other population subgroups, including the general U . S . population. The acute and chronic dietary exposure assessments sup port the new uses and amendments proposed for py raclostrobin . **X. List of Attachments**  Attachment 1. Py

raclostrobin Acute Dietary Analy sis Input File - Food & Water . Attachment 2 . Py

raclostrobin Acute Dietary Analy sis Results - Food & Water . Attachment 3 . Py

raclostrobin Chronic Dietary Analy sis Input File - Food & Water . Attachment 4 . Py

raclostrobin Chronic Dietary Analy sis Result s - Food & Water .Py

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### Attachment 5 . Py

raclostrobin Screening Level Usage Anal ys is (SLUA) .Py

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### Attachment **1 . Pyraclostrobin Acute Dietary Analysis Input File**  **– Food & Water**  Filename: C: \ Documents and Settings \ sfunk \ My Documents \ DEEMversion3.16 \ PyracloAcuteR08 _04_15_13.R08 Chemical: Pyraclostrobin RfD(Chronic): .034 mg/kg bw/day NOEL(Chronic): 3.4 mg/kg bw/day RfD(Acute): 3 mg/kg bw/day NOEL(Acute): 300 mg/kg bw/day Date created/last modified: 03 - 20 - 2013/08:32:53 Program ver. 3.16, 03 - 08 - d Comment: Foo d and drinking water

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--------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------

------- 1400003000 14 Almond 0.040000 1.000 1.000 1400004000 14 Almond, oil 0.040000 1.000 1.000 1400004001 14 Almond, oil - babyfood 0.040000 1.000 1.000 1400003001 14 Almond - babyfood 0.040000 1.000 1.000 0401005000 4A Amaranth, leafy 23.380000 1.000 1.000 1100009000 11 Apple, dried 1.500000 8.000 1.000 1100009001 11 Apple, dried - babyfood 1.500000 8.000 1.000 1100007000 11 Apple, fruit with peel 1.500000 1.000 1.000 1100010000 11 Apple, juice 1.500000 0.200 1.000 1100010001 11 Apple, juice - babyfood 1.500000 0.200 1.000 1100008000 11 Apple, peeled fruit 1.500000 1.000 1.000 1100008001 11 Apple, peeled fruit - babyfood 1.500000 1.000 1.000 11000110 00 11 Apple, sauce 1.500000 1.000 1.000 1100011001 11 Apple, sauce - babyfood 1.500000 1.000 1.000 1202012000 12B Apricot 2.500000 1.000 1.000 1202013000 12B Apricot, dried 2.500000 6.000 1.000 1202014000 12B Apricot, juice 2.500000 1.000 1.000 1202014001 12B Apricot, juice - babyfood 2.500000 1.000 1.000 1202012001 12B Apricot - babyfood 2.50000 0 1.000 1.000 0103015000 1CD Arrowroot, flour 0.040000 1.000 1.000 0103017000 1CD Artichoke, Jerusalem 0.040000 1.000 1.000 9500016000 O Artichoke, globe 3.000000 1.000 1.000 040101 8000 4A Arugula 23.380000 1.000 1.000 9500020000 O Avocado 0.600000 1.000 1.000 0902021000 9B Balsam pear 0.500000 1.000 1.000 9500023000 O Banana 0.040000 1.000 1.000 9500024000 O Banana, dried 0.040000 3.900 1.000 9500024001 O Banana, dried - babyfood 0.040000 3.900 1.000 9500023001 O Banana - babyfood 0.040 000 1.000 1.000 1500027000 15 Barley, bran 1.400000 1.000 1.000 1500026000 15 Barley, flour 1.400000 1.000 1.000 1500026001 15 Barley, flour - babyfood 1.400000 1.000 1. 000 1500025000 15 Barley, pearled barley 1.400000 1.000 1.000 1500025001 15 Barley, pearled barley - babyfood 1.400000 1.000 1.000 1901029000 19A Basil, dried leaves 85.000000 1.000 1.000 1901029 001 19A Basil, dried leaves - babyfood 85.000000 1.000 1.000Py

raclostrobin Dietary Exposure and Risk Assessment DP Number: 410739

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Page **14** of **34** 1901028000 19A Basil, fresh leaves 25.000000 1.000 1.000 1901028001 19A Basil, fresh leaves - babyfood 25.000000 1.000 1.000 0603035000 6C Bean, great nor thern, seed 0.210000 1.000 1.000 0603030000 6C Bean, black, seed 0.210000 1.000 1.000 0603032000 6C Bean, broad, seed 0.210000 1.000 1.000 0602031000 6B Bean, broad, succulent 0.5000 00 1.000 1.000 0603034000 6C Bean, cowpea, seed 0.210000 1.000 1.000 0602033000 6B Bean, cowpea, succulent 0.500000 1.000 1.000 0603036000 6C Bean, kidney, seed 0.210000 1.000 1.000 06030 38000 6C Bean, lima, seed 0.210000 1.000 1.000 0602037000 6B Bean, lima, succulent 0.500000 1.000 1.000 0603039000 6C Bean, mung, seed 0.210000 1.000 1.000 0603040000 6C Bean, navy, se ed 0.210000 1.000 1.000 0603041000 6C Bean, pink, seed 0.210000 1.000 1.000 0603042000 6C Bean, pinto, seed 0.210000 1.000 1.000 0601043000 6A Bean, snap, succulent 0.50 0000 1.000 1.000 0601043001 6A Bean, snap, succulent - babyfood 0.500000 1.000 1.000 3100047000 31 Beef, fat 0.100000 1.000 1.000 3100047001 31 Beef, fat - babyfood 0.100000 1.000 1.000 310 0048000 31 Beef, kidney 0.200000 1.000 1.000 3100049000 31 Beef, liver 1.500000 1.000 1.000 3100049001 31 Beef, liver - babyfood 1.500000 1.000 1.000 3100044000 31 Beef, meat 0.100000 1.000 1.000 3100046000 31 Beef, meat byproducts 0.200000 1.000 1.000 3100046001 31 Beef, meat byproducts - babyfood 0.200000 1.000 1.000 3100045000 31 Beef, meat, dried 0. 100000 1.920 1.000 3100044001 31 Beef, meat - babyfood 0.100000 1.000 1.000 0101050000 1AB Beet, garden, roots 0.400000 1.000 1.000 0101050001 1AB Beet, garden, roots - babyfood 0.400000 1.000 1.000 0 200051000 2 Beet, garden, tops 16.000000 1.000 1.000 0101052000 1A Beet, sugar 0.200000 0.400 1.000 0101053000 1A Beet, sugar, molasses 0.200000 0.400 1.000 0101053001 1A Beet, suga r, molasses - babyfood 0.200000 0.400 1.000 0101052001 1A Beet, sugar - babyfood 0.200000 0.400 1.000 9500054000 O Belgium endive 4.000000 1.000 1.000 1301055000 13A Blackberry 4.000000 1.000 1.000 1301056000 13A Blackberry, juice 4.000000 1.000 1.000 1301056001 13A Blackberry, juice - babyfood 4.000000 1.000 1.000 1302057000 13B Blueberry 4.000000 1.000 1.000 1302057001 13B Blueberry - babyfood 4.000000 1.000 1.000 1301058000 13A Boysenberry 4.000000 1.000 1.000 1400059000 14 Brazil nut 0.040000 1.000 1.000 0501061000 5A Broccoli 5.000000 1.000 1.000 0502063000 5B Broccoli raab 16.000000 1.000 1.000 0501062000 5A Broccoli, Chinese 5.000000 1.000 1.000 0501061001 5A Broccoli - babyfood 5.000000 1.000 1.000 0501064000 5A Brussels sprouts 5.000000 1.000 1.000 0101067000 1AB Burdock 0.400000 1.000 1.000 1400068000 14 Butternut 0.040000 1.000 1.000 0501069000 5A Cabbage 5.000000 1.000 1.000 0502070000 5B Cabbage, Chinese, bok choy 16.000000 1.000 1.000 0501072000 5A Cabbage, Chinese, mustard 5.000000 1.000 1.000 0501071000 5A Cabbag e, Chinese, napa 5.000000 1.000 1.000 9500074000 O Canistel 0.600000 1.000 1.000Py

raclostrobin Dietary Exposure and Risk Assessment DP Number: 410739

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Page **15** of **34** 0901075000 9A Cantaloupe 0.500000 1.000 1.000 0402076000 4B Cardoon 23.380000 1.000 1.000 0101078000 1AB Carrot 0.400000 1.000 1.000 0101079000 1AB Carrot, juice 0.400000 1.000 1.000 0101078001 1AB Carrot - babyfood 0.400000 1.000 1.0 00 1400081000 14 Cashew 0.040000 1.000 1.000 0103082000 1CD Cassava 0.040000 1.000 1.000 0103082001 1CD Cassava - babyfood 0.040000 1.000 1.000 0501083000 5A Caul iflower 5.000000 1.000 1.000 0101084000 1AB Celeriac 0.400000 1.000 1.000 0402085000 4B Celery 10.700000 1.000 1.000 0402086000 4B Celery, juice 10.700000 1.000 1.000 0402085001 4B Celery - babyfood 10.700000 1.000 1.000 0402087000 4B Celtuce 10.700000 1.000 1.000 0902088000 9B Chayote, fruit 0.500000 1.000 1 .000 1201090000 12A Cherry 2.500000 1.000 1.000 1201091000 12A Cherry, juice 2.500000 1.500 1.000 1201091001 12A Cherry, juice - babyfood 2.500000 1.500 1.000 1201090001 12A Ch erry - babyfood 2.500000 1.000 1.000 1400092000 14 Chestnut 0.040000 1.000 1.000 4000096000 40 Chicken, fat 0.100000 1.000 1.000 4000096001 40 Chicken, fat - babyfood 0.100000 1.000 1.000 4000094000 40 Chicken, liver 0.100000 1.000 1.000 4000093000 40 Chicken, meat 0.100000 1.000 1.000 4000095000 40 Chicken, meat byproducts 0.100000 1.000 1.000 4000095001 40 Chicken, meat byproducts - babyfoo 0.100000 1.000 1.000 4000093001 40 Chicken, meat - babyfood 0.100000 1.000 1.000 4000097000 40 Chicken, skin 0.100000 1.000 1.000 4000097001 40 Chicken, skin - babyfood 0.100000 1.000 1.000 0603099000 6C Chickpea, flour 0.340000 1.000 1.000 0603098000 6C Chickpea, seed 0.340000 1.000 1.000 0603098001 6C Chickpea, seed - babyfood 0.340000 1.000 1.000 0101100000 1AB Chicory, roots 0.400000 1.000 1.000 0200101000 2 Chicory, tops 16.000000 1.000 1.000 0902102000 9B Chinese waxgourd 0.500000 1.00 0 1.000 0302103000 3B Chive, fresh leaves 25.000000 1.000 1.000 0401104000 4A Chrysanthemum, garland 23.380000 1.000 1.000 1901118000 19A Cilantro, leaves 25.000000 1.000 1.000 1901118001 19A Cilantro, leaves - babyfood 25.000000 1.000 1.000 1001106000 10A Citron 2.000000 1.000 1.000 1001107000 10A Citrus hybrids 2.000000 1.000 1.000 1001108000 10A Citrus, oil 9.000000 1.000 1.000 9500116000 O Coffee, instant 0.300000 1.000 1.000 9500115000 O Coffee, roasted bean 0.300000 1.000 1.000 0502117000 5B Collards 16.000000 1. 000 1.000 1500122000 15 Corn, field, bran 0.100000 1.000 1.000 1500120000 15 Corn, field, flour 0.100000 1.000 1.000 1500120001 15 Corn, field, flour - babyfood 0.100000 1.000 1.000 1500121000 1 5 Corn, field, meal 0.100000 1.000 1.000 1500121001 15 Corn, field, meal - babyfood 0.100000 1.000 1.000 1500125000 15 Corn, field, oil 0.200000 1.000 1.000 1500125001 15 Corn, field, oil - baby food 0.200000 1.000 1.000 1500123000 15 Corn, field, starch 0.100000 1.000 1.000 1500123001 15 Corn, field, starch - babyfood 0.100000 1.000 1.000Py

raclostrobin Dietary Exposure and Risk Assessment DP Number: 410739

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Page **16** of **34** 1500124000 15 Corn, field, syrup 0.100000 1.500 1.000 1500124001 15 Corn, field, syrup - babyfood 0.100000 1.500 1.000 1500126000 15 Corn, pop 0.100000 1.000 1.000 1500127000 15 Corn, sweet 0.040000 1.000 1.000 1500127001 15 Corn, sweet - babyfood 0.040000 1.000 1.000 2003128000 20C Cottonseed, oil 0.300000 1.000 1.000 2003128001 20C Cottonseed, oil - babyfood 0.300000 1.000 1.000 1100129000 11 Crabapple 1.500000 1.000 1.000 0401133000 4A Cress, garden 23.380000 1.000 1.000 0401134000 4A Cress, upland 23.380000 1.000 1.000 0902135000 9B Cucumber 0.500000 1.000 1.000 1302136000 13B Currant 4.000000 1.000 1.000 1302137000 13B Currant, dried 4.000000 1.000 1.000 0401138000 4A Dandelion, leaves 23.380000 1.000 1.000 01031390 00 1CD Dasheen, corm 0.040000 1.000 1.000 0200140000 2 Dasheen, leaves 16.000000 1.000 1.000 1902143000 19B Dill, seed 25.000000 1.000 1.000 1901144000 19A Dillweed 25.000000 1.000 1.000 7000146000 70 Egg, white 0.100000 1.000 1.000 7000146001 70 Egg, white (solids) - babyfood 0.100000 1.000 1.000 7000145000 70 Egg, whole 0.10000 0 1.000 1.000 7000145001 70 Egg, whole - babyfood 0.100000 1.000 1.000 7000147000 70 Egg, yolk 0.100000 1.000 1.000 7000147001 70 Egg, yolk - babyfood 0.100000 1.000 1.000 080214 8000 8BC Eggplant 1.400000 1.000 1.000 1302149000 13B Elderberry 4.000000 1.000 1.000 0401150000 4A Endive 23.380000 1.000 1.000 0402152000 4B Fennel, Florenc e 23.380000 1.000 1.000 2001163000 20A Flax seed, oil 0.450000 1.200 1.000 0301165000 3A Garlic, bulb 0.900000 1.000 1.000 0301165001 3A Garlic, bulb - babyfood 0.900 000 1.000 1.000 0103166000 1CD Ginger 0.040000 1.000 1.000 0103167000 1CD Ginger, dried 0.040000 1.000 1.000 0101168000 1AB Ginseng, dried 0.400000 1.000 1.000 3200 171000 32 Goat, fat 0.100000 1.000 1.000 3200172000 32 Goat, kidney 0.200000 1.000 1.000 3200173000 32 Goat, liver 1.500000 1.000 1.000 3200169000 32 Goat, meat 0.100000 1.000 1.000 3200170000 32 Goat, meat byproducts 0.200000 1.000 1.000 1100173500 11 Goji berry 1.500000 1.000 1.000 1302174000 13B Gooseberry 4.0 00000 1.000 1.000 1304175000 13D Grape 2.000000 1.000 1.000 1304176000 13D Grape, juice 2.000000 0.010 1.000 1304176001 13D Grape, juice - babyfood 2.000000 0.010 1.000 95 00177000 O Grape, leaves 2.000000 1.000 1.000 9500178000 O Grape, raisin 7.000000 1.000 1.000 1304179000 13D Grape, wine and sherry 2.000000 1.000 1.000 1003180000 10C Grapefruit 2.000000 1.000 1.000 1003181000 10C Grapefruit, juice 2.000000 0.020 1.000 0603182000 6C Guar, seed 0.340000 1.000 1.000 0603182001 6C Guar, seed - babyfood 0 .340000 1.000 1.000 1400155000 14 Hazelnut 0.040000 1.000 1.000 1400156000 14 Hazelnut, oil 0.040000 1.000 1.000 1901184000 19A Herbs, other 25.000000 1.000 1.000Py

raclostrobin Dietary Exposure and Risk Assessment DP Number: 410739

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Page **17** of **34** 1901184001 19A Herbs, other - babyfood 25.000000 1.000 1.000 1400185000 14 Hickory nut 0.040000 1.000 1.000 0901187000 9A Honeydew melon 0.500000 1.000 1.000 9500188000 O Hop 23.000000 1.000 1.000 3300189000 33 Horse, meat 0.100000 1.000 1.000 0101190000 1AB Horseradish 0.400000 1.000 1.000 1302191000 13B Huckleberry 4.000000 1.000 1.000 0502194000 5B Kale 16.000000 1.000 1.000 1304195000 13D Kiwifruit, fuzzy 4.000000 1.000 1.000 0501196000 5A Kohlrabi 5.000000 1.000 1.000 1002197000 10B Kumquat 2.000000 1.000 1.000 0302198000 3B Leek 0.900000 1.000 1.000 1002199000 10B Lemon 2.000000 1.000 1.000 1002200000 10B Lemon, juice 2.000000 0.020 1.000 1002200001 10B Lemon, juice - babyfood 2.000000 0.020 1.000 1002201000 10B Lemon, peel 2.000000 1.000 1.000 1901202000 19A Lemongrass 25.000000 1.000 1.000 0603203000 6C Lentil, seed 0.340000 1.000 1.000 0401204000 4A Lettuce, head 14.400000 1.000 1.000 0401205000 4A Lettuce, leaf 20.100000 1.000 1.00 0 1002206000 10B Lime 2.000000 1.000 1.000 1002207000 10B Lime, juice 2.000000 0.020 1.000 1002207001 10B Lime, juice - babyfood 2.000000 0.020 1.000 1301208000 13A Logan berry 4.000000 1.000 1.000 1100210000 11 Loquat 1.500000 1.000 1.000 1400213000 14 Macadamia nut 0.040000 1.000 1.000 9500215000 O Mango 0.600000 1.000 1.000 9500216000 O Mango, dried 0.600000 1.000 1.000 9500217000 O Mango, juice 0.600000 1.000 1.000 9500217001 O Mango, juice - babyfood 0.600000 1.000 1. 000 9500215001 O Mango - babyfood 0.600000 1.000 1.000 1901220000 19A Marjoram 25.000000 1.000 1.000 1901220001 19A Marjoram - babyfood 25.000000 1.000 1.000 3800221000 38 Mea t, game 0.100000 1.000 1.000 3600222000 36 Milk, fat 0.100000 1.000 1.000 3600222001 36 Milk, fat - baby food/infant formu 0.100000 1.000 1.000 3600223000 36 Milk, nonfat solids 0.100000 1.000 1.000 3600223001 36 Milk, nonfat solids - baby food/in 0.100000 1.000 1.000 3600225001 36 Milk, sugar (lactose) - baby food/ 0.100000 1.000 1.000 3600224000 36 Milk, water 0.100000 1.000 1.000 3600224001 36 Milk, water - babyfood/infant form 0.100000 1.000 1.000 1303227000 13C Mulberry 4.000000 1.000 1.000 0502229000 5B Mustard greens 16.000000 1.000 1.000 1202230000 12B N ectarine 2.500000 1.000 1.000 1500231000 15 Oat, bran 1.200000 1.000 1.000 1500232000 15 Oat, flour 1.200000 1.000 1.000 1500232001 15 Oat, flour - babyfood 1.200000 1.000 1.000 1500233000 15 Oat, groats/rolled oats 1.200000 1.000 1.000 1500233001 15 Oat, groats/rolled oats - babyfood 1.200000 1.000 1.000 0802234000 8BC Okra 1.4 00000 1.000 1.000 0301237000 3A Onion, bulb 0.900000 1.000 1.000 0301238000 3A Onion, bulb, dried 0.900000 9.000 1.000 0301238001 3A Onion, bulb, dried - babyfood 0.900000 9.000 1.000Py

raclostrobin Dietary Exposure and Risk Assessment DP Number: 410739

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Page **18** of **34** 03 01237001 3A Onion, bulb - babyfood 0.900000 1.000 1.000 0302239000 3B Onion, green 0.900000 1.000 1.000 1001240000 10A Orange 2.000000 1.000 1.000 1001241000 10A Orange, jui ce 2.000000 0.020 1.000 1001241001 10A Orange, juice - babyfood 2.000000 0.020 1.000 1001242000 10A Orange, peel 2.000000 1.000 1.000 9500245000 O Papaya 0 .600000 1.000 1.000 9500246000 O Papaya, dried 0.600000 1.800 1.000 9500247000 O Papaya, juice 0.600000 1.500 1.000 9500245001 O Papaya - babyfood 0.600000 1.000 1.000 1901249000 19A Parsley, dried leaves 85.000000 1.000 1.000 1901249001 19A Parsley, dried leaves - babyfood 85.000000 1.000 1.000 0401248000 4A Parsley, leaves 23.380000 1.000 1.000 0101250000 1AB Parsley, turnip rooted 0.400000 1.000 1.000 0101251000 1AB Parsnip 0.400000 1.000 1.000 0101251001 1AB Parsnip - babyfood 0.400000 1.000 1.000 0603256000 6C Pea, dry 0.100000 1.000 1.000 0603256001 6C Pea, dry - babyfood 0.100000 1.000 1.000 0601257000 6A Pea, edible podded, succulent 0.500000 1.000 1.000 0603258000 6C Pea, pigeon, seed 0.100000 1.000 1.000 0602259000 6B Pea, pigeon, succulent 0.200000 1.000 1.000 0602255000 6B Pea, succulent 0.200000 1.000 1.000 0602255001 6B Pea, succulent - babyfood 0.200000 1.000 1.000 1202260000 12B Peach 2.500000 1.000 1.000 1202261000 12B Peach, dried 2.500000 7.000 1.000 1202261001 12B Peach, dried - babyfood 2.500000 7.000 1.000 1202262000 12B Peach, juice 2.500000 1.000 1.000 1202262001 12B Peach, juice - babyfood 2.500000 1.000 1.000 1202260001 12B Peach - babyfood 2.500000 1.000 1.000 9500263000 O Peanut 0.050000 1.000 1.00 0 9500264000 O Peanut, butter 0.050000 1.890 1.000 9500265000 O Peanut, oil 0.100000 1.000 1.000 1100266000 11 Pear 1.500000 1.000 1.000 1100267000 11 Pear, dried 1.500000 6.250 1.000 1100268000 11 Pear, juice 1.500000 1.000 1.000 1100268001 11 Pear, juice - babyfood 1.500000 1.000 1.000 1100266001 11 Pear - babyfood 1.500000 1.000 1.000 1400269000 14 Pecan 0.040000 1.000 1.000 0802270000 8B Pepper, bell 1.400000 1.000 1.000 0802271000 8B Pepper, bell, dried 1.400000 1.000 1. 000 0802271001 8B Pepper, bell, dried - babyfood 1.400000 1.000 1.000 0802270001 8B Pepper, bell - babyfood 1.400000 1.000 1.000 0802272000 8BC Pepper, nonbell 1.400000 1.000 1.000 0802273000 8BC Pep per, nonbell, dried 1.400000 1.000 1.000 0802272001 8BC Pepper, nonbell - babyfood 1.400000 1.000 1.000 9500275000 O Peppermint 8.000000 1.000 1.000 9500276000 O Peppermint, oil 8.000000 1.000 1.000 9500277000 O Persimmon 3.000000 1.000 1.000 1400278000 14 Pine nut 0.040000 1.000 1.000 1400282000 14 Pistachio 0.700000 1.000 1.000 9500283000 O Plantain 0.040000 1.000 1.000 9500284000 O Plantain, dried 0.040000 3.900 1.000 1203285000 12C Plum 2.500000 1.000 1.000 1203287000 12C P lum, prune, dried 2.500000 1.300 1.000Py

raclostrobin Dietary Exposure and Risk Assessment DP Number: 410739

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Page **19** of **34** 1203287001 12C Plum, prune, dried - babyfood 2.500000 1.300 1.000 1203286000 12C Plum, prune, fresh 2.500000 1.000 1.000 1203286001 12C Plum, prune, fresh - babyfoo d 2.500000 1.000 1.000 1203288000 12C Plum, prune, juice 2.500000 1.400 1.000 1203288001 12C Plum, prune, juice - babyfood 2.500000 1.400 1.000 1203285001 12C Plum - babyfood 2.500000 1.000 1.000 3400293000 34 Pork, fat 0.100000 1.000 1.000 3400293001 34 Pork, fat - babyfood 0.100000 1.000 1.000 3400294000 34 Pork, kidney 0.200000 1.000 1.000 3400295000 34 Pork, liver 1.500000 1.000 1.000 3400290000 34 Pork, meat 0.100000 1.000 1.000 3400292000 34 Pork, meat byproducts 0.200000 1.000 1.000 3400292001 34 Pork, meat byproducts - ba byfood 0.200000 1.000 1.000 3400290001 34 Pork, meat - babyfood 0.100000 1.000 1.000 3400291000 34 Pork, skin 0.100000 1.000 1.000 0103296000 1C Potato, chips 0.040000 1.0 00 1.000 0103297000 1C Potato, dry (granules/ flakes) 0.040000 1.000 1.000 0103297001 1C Potato, dry (granules/ flakes) - b 0.040000 1.000 1.000 0103298000 1C Potato, flour 0.040000 1.000 1.000 0103298001 1C Potato, flour - babyfood 0.040000 1.000 1.000 0103300000 1C Potato, tuber, w/o peel 0.040000 1.000 1.000 0103300001 1C Potato, tuber, w/o peel - babyfood 0.040000 1.000 1.000 0103299000 1C Potato, tuber, w/peel 0.040000 1.000 1.000 6000304000 60 Poultry, other, fat 0.100000 1.000 1.000 6000302000 60 Poultry, other, liver 0.100000 1.000 1.000 6000301000 60 Poultry, other, meat 0.100000 1 .000 1.000 6000303000 60 Poultry, other, meat byproducts 0.100000 1.000 1.000 6000305000 60 Poultry, other, skin 0.100000 1.000 1.000 1003307000 10C Pummelo 2.000000 1.000 1.000 0902308000 9B Pumpkin 0.500000 1.000 1.000 0902309000 9B Pumpkin, seed 0.500000 1.000 1.000 1100310000 11 Quince 1.500000 1.000 1.000 3900312000 39 Rabbit, meat 0.100000 1.000 1.000 0401313000 4A Radicchio 23.380000 1.000 1.000 0101316000 1AB Radish, Oriental, roots 0.400000 1.000 1.000 0101314000 1AB Radish, roots 0.400000 1.000 1.000 0502318000 5B Rape greens 16.000000 1.000 1.000 2001319000 20A Rapeseed, oil 0.450000 1.000 1.000 2001319001 20A Rapeseed, oil - babyfood 0.450000 1.000 1.000 130132000 0 13A Raspberry 4.000000 1.000 1.000 1301321000 13A Raspberry, juice 4.000000 1.000 1.000 1301321001 13A Raspberry, juice - babyfood 4.000000 1.000 1.000 1301320001 13A Raspberry - babyfood 4.000000 1.000 1.000 0402322000 4B Rhubarb 23.380000 1.000 1.000 0101327000 1AB Rutabaga 0.400000 1.000 1.000 1500328000 15 Rye, grain 0.040000 1.000 1.000 2002330000 20B Safflower, oil 0.450000 1.000 1.000 2002330001 20B Safflower, oil - babyfood 0.450000 1.000 1.000 0101331000 1AB Salsify, roots 0.400000 1.000 1. 000 9500333000 O Sapote, Mamey 0.600000 1.000 1.000 1901334000 19A Savory 25.000000 1.000 1.000 2001337000 20A Sesame, oil 0.450000 1.000 1.000 2001337001 20A Ses ame, oil - babyfood 0.450000 1.000 1.000Py

raclostrobin Dietary Exposure and Risk Assessment DP Number: 410739

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Page **20** of **34** 2001336000 20A Sesame, seed 0.450000 1.000 1.000 2001336001 20A Sesame, seed - babyfood 0.450000 1.000 1.000 0301338000 3A Shallot, bulb 0.900000 1.000 1.000 0302338500 3B Shallot, fresh leaves 0.900000 1.000 1.000 3500341000 35 Sheep, fat 0.100000 1.000 1.000 3500341001 35 Sheep, fat - babyfood 0.100000 1.000 1.000 3500342000 35 Sheep, kidney 0.200000 1.000 1.000 3500343000 35 Sheep, liver 1.500000 1.000 1.000 3500339000 35 Sheep, meat 0.100000 1.000 1.000 3500340000 35 S heep, meat byproducts 0.200000 1.000 1.000 3500339001 35 Sheep, meat - babyfood 0.100000 1.000 1.000 1500344000 15 Sorghum, grain 0.600000 1.000 1.000 1500345000 15 Sorghum, syrup 0.600000 1.000 1.000 0603348000 6C Soybean, flour 0.040000 1.000 1.000 0603348001 6C Soybean, flour - babyfood 0.040000 1.000 1.000 0600350000 6 Soybean, oil 0.040000 0.800 1.000 0600350001 6 Soybean, oil - babyfood 0.040000 0.800 1.000 0600347000 6 Soybean, seed 0.040000 1.000 1.000 0600349000 6 Soybean, soy milk 0.040000 1.000 1.000 0600349001 6 Soybean, soy milk - babyfood or in 0.040000 1.000 1.000 9500352000 O Spearmint 8.000000 1.000 1.000 9500353000 O Spearmint, oil 8.000000 1.000 1.000 0401355000 4A Spinach 23.380000 1.000 1.000 0401355001 4A Spinach - babyfood 23.380000 1.000 1.000 0902356000 9B Squash, summer 0.500000 1.000 1.000 0902356001 9B Squash, summer - babyfood 0.500000 1.0 00 1.000 0902357000 9B Squash, winter 0.500000 1.000 1.000 0902357001 9B Squash, winter - babyfood 0.500000 1.000 1.000 1307359000 13G Strawberry 4.000000 1.000 1.000 1307360000 13 G Strawberry, juice 1.200000 1.000 1.000 1307360001 13G Strawberry, juice - babyfood 1.200000 1.000 1.000 1307359001 13G Strawberry - babyfood 1.200000 1.000 1.000 9500363000 O Sugarcane, molasses 0.200000 0.150 1.000 9500363001 O Sugarcane, molasses - babyfood 0.200000 0.150 1.000 9500362000 O Sugarcane, sugar 0.200000 0.150 1.000 9500362001 O Sugarcane, sugar - babyfood 0.200000 0 .150 1.000 2002365000 20B Sunflower, oil 0.450000 1.000 1.000 2002365001 20B Sunflower, oil - babyfood 0.450000 1.000 1.000 2002364000 20B Sunflower, seed 0.450000 1.000 1.000 0103366000 1CD Sweet potato 0.040000 1.000 1.000 0103366001 1CD Sweet potato - babyfood 0.040000 1.000 1.000 0402367000 4B Swiss chard 23.380000 1.000 1.000 1001369000 10A Tangerine 2.000000 1.000 1.000 1001370000 10A Tangerine, juice 2.000000 0.020 1.000 0103371000 1CD Tanier, corm 0.040000 1.000 1.000 0801374000 8A Tomatillo 1.400000 1.000 1.000 0801375000 8A Tomato 1.400000 1.000 1.000 0801380000 8A Tomato, Tree 1.400000 1.000 1.000 0801378000 8A Tomato, dried 1.400000 14.300 1.000 080137800 1 8A Tomato, dried - babyfood 1.400000 14.300 1.000 0801379000 8A Tomato, juice 1.400000 1.500 1.000 0801376000 8A Tomato, paste 1.400000 2.100 1.000 0801376001 8A Tomato, paste - baby food 1.400000 2.100 1.000 0801377000 8A Tomato, puree 1.400000 0.550 1.000Py

raclostrobin Dietary Exposure and Risk Assessment DP Number: 410739

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Page **21** of **34** 0801377001 8A Tomato, puree - babyfood 1.400000 0.550 1.000 0801375001 8A Tomato - babyfood 1.400000 1.000 1.000 1500381000 15 Triticale, flour 0.020000 0.700 1.000 1500381001 15 Triticale, flour - babyfood 0.020000 1.000 1.000 5000385000 50 Turkey, fat 0.100000 1.000 1.000 5000385 001 50 Turkey, fat - babyfood 0.100000 1.000 1.000 5000383000 50 Turkey, liver 0.100000 1.000 1.000 5000383001 50 Turkey, liver - babyfood 0.100000 1.000 1.000 5000382000 50 Turkey, meat 0.100000 1.000 1.000 5000384000 50 Turkey, meat byproducts 0.100000 1.000 1.000 5000384001 50 Turkey, meat byproducts - babyfood 0.100000 1.000 1.000 5000382001 50 Turkey, meat - babyfood 0.1000 00 1.000 1.000 5000386000 50 Turkey, skin 0.100000 1.000 1.000 5000386001 50 Turkey, skin - babyfood 0.100000 1.000 1.000 0103387000 1CD Turmeric 0.040000 1.000 1.000 05023 89000 5B Turnip, greens 16.000000 1.000 1.000 0101388000 1AB Turnip, roots 0.400000 1.000 1.000 1400391000 14 Walnut 0.040000 1.000 1.000 8601000000 86A Water, direct, all sources 0.035600 1.000 1.000 8602000000 86B Water, indirect, all sources 0.035600 1.000 1.000 0901399000 9A Watermelon 0.500000 1.000 1.000 0901400000 9A Watermelon, juice 0.50 0000 1.000 1.000 1500404000 15 Wheat, bran 0.020000 1.000 1.000 1500402000 15 Wheat, flour 0.020000 0.700 1.000 1500402001 15 Wheat, flour - babyfood 0.020000 0.700 1.000 150 0403000 15 Wheat, germ 0.020000 0.850 1.000 1500401000 15 Wheat, grain 0.020000 1.000 1.000 1500401001 15 Wheat, grain - babyfood 0.020000 1.000 1.000 0103407000 1CD Yam bean 0.040000 1.000 1.000 0103406000 1CD Yam, true 0.040000 1.000 1.000



### Attachment 2 **. Pyraclostrobin Acute Dietary Analysis Results –**  **Food & Water** US EPA Ver. 3.16, 03 - 08 - d DEEM - FCID ACUTE Analysis for PYRACLOSTROBIN NHANES 2003 - 2008 2 - Day Residue file: PyracloAcuteR08_04_15_13.R08 Adjustment factor #2 NOT used. Analysis Date: 04 - 23 - 2013/07:06:22 Residue file dated: 04 - 23 - 2013/07:04:21 NOEL (Acute) = 300.000000 mg/kg body - wt/day RAC/FF intake summed over 24 hours Run Comment: "Food and drinking water"

=============================================================================== Summary calculations -- per capita:

--- 9 5th Percentile ---- --- 99th Percentile ---- --- 99.9th Percentile ---- Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE

---------- ------- -------- ---------- ------- -------- ---------- ------- -------- Total US Pop ulation: 0.044721 1.49 6708 0.077398 2.58 3876 0.126870 4.23 2364 All Infants: 0.061716 2.06 4860 0.094284 3.14 3181 0.253340 8.44 1184Py

raclostrobin Dietary Exposure and Risk Assessment DP Number: 410739

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Page **22** of **34** Children 1 - 2: 0.083049 2.77 3612 0.126814 4.23 2365 0.200895 6.70 1493 Children 3 - 5: 0.074666 2.49 4017 0.124057 4.14 2418 0.201824 6.73 1486 Children 6 - 12: 0.044251 1.48 6779 0.076218 2.54 3936 0.110749 3.69 2708 Youth 13 - 19: 0.03150 6 1.05 9522 0.058879 1.96 5095 0.112688 3.76 2662 Adults 20 - 49: 0.041724 1.39 7190 0.072384 2.41 4144 0.115778 3.86 2591 Adults 50 - 99: 0.041722 1.39 7190 0.069793 2.33 4298 0.118280 3.94 2536

US EPA Ver. 3.16, 03 - 08 - d DEEM - FCID ACUTE Analysis for PYRACLOSTROBIN NHANES 2003 - 2008 2 - Day Residue file: PyracloAcuteR08_04_15_13.R08 Adjustment factor #2 NOT u sed. Analysis Date: 04 - 23 - 2013/07:08:44 Residue file dated: 04 - 23 - 2013/07:04:21 NOEL (Acute) = 5.000000 mg/kg body - wt/day RAC/FF intake summed over 24 hours Run Comment: "Food and drinking water"

======================================================= ======================== Summary calculations -- per capita:

--- 95th Percentile ---- --- 99th Percentile ---- --- 99.9th Percentile ---- Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE

---------- ------- -------- ---------- ------- -------- ---------- ------- -------- Female 13 - 49: 0.043481 86.96 114 0.073936 147.87 67 0.120543 241.09 41Py

raclostrobin Dietary Exposure and Risk Assessment DP Number: 410739

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Page **23** of **34** 

### Attachment **3 . Pyraclostrobin Chronic Dietary Analysis Input File**  **– Fo**  **od & Water** Filename: C: \ Documents and Settings \ sfunk \ My Documents \ DEEMversion3.16 \ PyracloChronic04_15_13.R08 Chemical: Pyraclostrobin RfD(Chronic): .034 mg/kg bw/day NOEL(Chronic): 3.4 mg/kg bw/day RfD(Acute): 3 mg/kg bw/day NOEL(Acute): 300 mg/kg bw/day Date created/last mod ified: 04 - 15 - 2013/10:38:44 Program ver. 3.16, 03 - 08 - d Comment: Food and drinking water

--------------------------------------------------------------------------

--------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------

------- 1400003000 14 Almond 0.040000 1.000 0.400 1400004000 14 Almond, oil 0.040000 1.000 0.400 1400004001 14 Almond, oil - babyfood 0.040000 1.000 1.000 1400003001 14 Almond - babyfood 0.040000 1.000 1.000 0401005000 4A Amaranth, leafy 11.770000 1.000 1.000 1100009000 11 Apple, dried 0.310000 8.000 0.150 1100009001 11 Apple, dried - babyfood 0.310000 8.000 0.150 1100007000 11 Apple, fruit with peel 0.310000 1.0 00 0.150 1100010000 11 Apple, juice 0.310000 0.200 0.150 1100010001 11 Apple, juice - babyfood 0.310000 0.200 0.150 1100008000 11 Apple, peeled fruit 0.310000 1.000 0.150 1100008001 11 Apple, peeled fruit - babyfood 0.310000 1.000 0.150 1100011000 11 Apple, sauce 0.310000 1.000 0.150 1100011001 11 Apple, sauce - babyfood 0.310000 1.000 0.150 1202012000 12B Apricot 0.602000 1.000 0.250 1202013000 12B Apricot, dried 0.602000 6.000 0.250 1202014000 12B Apricot, juice 0.602000 1.000 0.250 1202014001 12B Apricot, juice - babyfood 0.602000 1 .000 0.250 1202012001 12B Apricot - babyfood 0.602000 1.000 0.250 0103015000 1CD Arrowroot, flour 0.040000 1.000 1.000 0103015001 1CD Arrowroot, flour - babyfood 0.040000 1.000 1.000 0103017000 1CD Artichoke, Jerusalem 0.040000 1.000 1.000 9500016000 O Artichoke, globe 0.840000 1.000 1.000 0401018000 4A Arugula 11.770000 1.000 1.000 9500020000 O Avocado 0.600000 1.000 1.000 0902021000 9B Balsam pear 0.500000 1.000 1.000 9500023000 O Banana 0.040000 1.000 1.000 9500024000 O Banana, dried 0.040000 3.900 1.000 9500024001 O Banana, dried - babyfood 0.040000 3.900 1.000 9500023001 O Banana - babyfood 0.040000 1.000 1.000 1500027000 15 Barley, bran 1.400000 1.000 0.100 150002600 0 15 Barley, flour 1.400000 1.000 0.100 1500026001 15 Barley, flour - babyfood 1.400000 1.000 0.100 1500025000 15 Barley, pearled barley 1.400000 1.000 0.100 1500025001 15 Barley, pearled ba rley - babyfood 1.400000 1.000 0.100Py

raclostrobin Dietary Exposure and Risk Assessment DP Number: 410739

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Page **24** of **34** 1901029000 19A Basil, dried leaves 85.000000 1.000 1.000 1901029001 19A Basil, dried leaves - babyfood 85.000000 1.000 1.000 1901028000 19A Basil, fresh leaves 25.000000 1.000 1.000 1901028001 19A Basil, fresh leaves - babyfood 25.000000 1.000 1.000 0603035000 6C Bean, great northern, seed 0.500000 1.000 0.100 0603030000 6C Bean, black, seed 0.500000 1.000 0.100 0603032 000 6C Bean, broad, seed 0.500000 1.000 0.100 0602031000 6B Bean, broad, succulent 0.500000 1.000 0.050 0603034000 6C Bean, cowpea, seed 0.500000 1.000 0.100 0602033000 6B Bean, cowpea, su cculent 0.500000 1.000 0.050 0603036000 6C Bean, kidney, seed 0.500000 1.000 0.100 0603038000 6C Bean, lima, seed 0.500000 1.000 0.100 0602037000 6B Bean, lima, succulent 0.5000 00 1.000 0.050 0603039000 6C Bean, mung, seed 0.500000 1.000 0.100 0603040000 6C Bean, navy, seed 0.500000 1.000 0.100 0603041000 6C Bean, pink, seed 0.500000 1.000 0.100 06030 42000 6C Bean, pinto, seed 0.050000 1.000 0.100 0601043000 6A Bean, snap, succulent 0.500000 1.000 0.050 0601043001 6A Bean, snap, succulent - babyfood 0.500000 1.000 0.050 3100047000 31 Beef, fat 0.100000 1.000 1.000 3100047001 31 Beef, fat - babyfood 0.100000 1.000 1.000 3100048000 31 Beef, kidney 0.200000 1.000 1.000 3100049000 31 Beef, liver 1.50 0000 1.000 1.000 3100049001 31 Beef, liver - babyfood 1.500000 1.000 1.000 3100044000 31 Beef, meat 0.100000 1.000 1.000 3100046000 31 Beef, meat byproducts 0.200000 1.000 1.000 310 0046001 31 Beef, meat byproducts - babyfood 0.200000 1.000 1.000 3100045000 31 Beef, meat, dried 0.100000 1.920 1.000 3100044001 31 Beef, meat - babyfood 0.100000 1.000 1.000 0101050000 1AB Beet, garden , roots 0.400000 1.000 1.000 0101050001 1AB Beet, garden, roots - babyfood 0.400000 1.000 1.000 0200051000 2 Beet, garden, tops 16.000000 1.000 1.000 0101052000 1A Beet, sugar 0. 200000 0.400 0.450 0101053000 1A Beet, sugar, molasses 0.200000 0.400 0.450 0101053001 1A Beet, sugar, molasses - babyfood 0.200000 0.400 0.450 0101052001 1A Beet, sugar - babyfood 0.200000 0.400 0.450 9 500054000 O Belgium endive 0.820000 1.000 1.000 1301055000 13A Blackberry 4.000000 1.000 0.500 1301056000 13A Blackberry, juice 4.000000 1.000 0.500 1301056001 13A Blackberry , juice - babyfood 4.000000 1.000 0.500 1302057000 13B Blueberry 4.000000 1.000 0.450 1302057001 13B Blueberry - babyfood 4.000000 1.000 0.450 1301058000 13A Boysenberry 4.000000 1.000 0.500 1400059000 14 Brazil nut 0.040000 1.000 1.000 0501061000 5A Broccoli 1.100000 1.000 0.050 0502063000 5B Broccoli raab 16.000000 1.000 1.000 0501062000 5A Broccoli, Chinese 5.000000 1.000 1.000 0501061001 5A Broccoli - babyfood 1.100000 1.000 0.050 0501064000 5A Brussels sprouts 5.000000 1.000 1.000 0101067000 1AB Burdock 0.400000 1.000 1.000 1400068000 14 Butternut 0.040000 1.000 1.000 0501069000 5A Cabbage 5.000000 1.000 0.100 0502070000 5B Cabbage, Chinese, bok choy 16.000000 1.000 1.000 0501072000 5A Cabbage, Chinese, mustard 5.000000 1.000 1.000Py

raclostrobin Dietary Exposure and Risk Assessment DP Number: 410739

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Page **25** of **34** 0501071000 5A Cabbage, Chinese, napa 5.000000 1.000 1.000 9500074000 O Canistel 0.600000 1.000 1.000 0901075000 9A Cantaloupe 0.500000 1.000 0.150 0402076000 4B Cardoon 5.020000 1.000 1.000 0101078000 1AB Carrot 0.400000 1.000 0.350 0101079000 1AB Carrot , juice 0.400000 1.000 0.350 0101078001 1AB Carrot - babyfood 0.400000 1.000 0.350 1400081000 14 Cashew 0.040000 1.000 1.000 0103082000 1CD Cassava 0.040000 1.000 1.000 0103082001 1CD Cassava - babyfood 0.040000 1.000 1.000 0501083000 5A Cauliflower 5.000000 1.000 0.025 0101084000 1AB Celeriac 0.400000 1.000 1.0 00 0402085000 4B Celery 5.020000 1.000 0.025 0402086000 4B Celery, juice 5.020000 1.000 0.025 0402085001 4B Celery - babyfood 5.020000 1.000 0.025 0402087000 4B Celt uce 5.020000 1.000 1.000 0902088000 9B Chayote, fruit 0.500000 1.000 1.000 1201090000 12A Cherry 0.846000 1.000 0.500 1201091000 12A Cherry, juice 0.846000 1.500 0.500 1201091001 12A Cherry, juice - babyfood 0.846000 1.500 0.500 1201090001 12A Cherry - babyfood 0.846000 1.000 0.500 1400092000 14 Chestnut 0.040000 1.000 1 .000 4000096000 40 Chicken, fat 0.100000 1.000 1.000 4000096001 40 Chicken, fat - babyfood 0.100000 1.000 1.000 4000094000 40 Chicken, liver 0.100000 1.000 1.000 4000093000 40 Ch icken, meat 0.100000 1.000 1.000 4000095000 40 Chicken, meat byproducts 0.100000 1.000 1.000 4000095001 40 Chicken, meat byproducts - babyfoo 0.100000 1.000 1.000 4000093001 40 Chicken, meat - babyfood 0.100000 1.000 1.000 4000097000 40 Chicken, skin 0.100000 1.000 1.000 4000097001 40 Chicken, skin - babyfood 0.100000 1.000 1.000 0603099000 6C Chickpea, flour 0.340000 1.000 0.100 0603098000 6C Chickpea, seed 0.340000 1.000 0.100 0603098001 6C Chickpea, seed - babyfood 0.340000 1.000 0.100 0101100000 1AB Chicory, roots 0.400000 1.000 1.000 0200101000 2 Chicory, tops 16.000000 1.000 1.000 0902102000 9B Chinese waxgourd 0.500000 1.000 1.000 0302103000 3B Chive, fresh leaves 25.000000 1.000 1.000 0401104000 4A Chrysanthemum, garland 11.770000 1.000 1.000 1901118000 19A Cilantro, leaves 25.000000 1.000 1.000 1901118001 19A Cilantro, leaves - babyfood 25.000000 1.000 1.000 1001106000 10A Citron 2.000000 1.00 0 1.000 1001107000 10A Citrus hybrids 2.000000 1.000 1.000 1001108000 10A Citrus, oil 9.000000 1.000 1.000 9500116000 O Coffee, instant 0.064000 1.000 1.000 9500115000 O Coffee, roasted bean 0.064000 1.000 1.000 0502117000 5B Collards 5.740000 1.000 1.000 1500122000 15 Corn, field, bran 0.100000 1.000 0.100 1500120000 15 Corn, field, flour 0.100000 1.000 0.100 1500120001 15 Corn, field, flour - babyfood 0.100000 1.000 0.100 1500121000 15 Corn, field, meal 0.100000 1.000 0.100 1500121001 15 Corn, field, meal - babyfood 0.100000 1. 000 0.100 1500125000 15 Corn, field, oil 0.200000 1.000 0.100 1500125001 15 Corn, field, oil - babyfood 0.200000 1.000 0.100Py

raclostrobin Dietary Exposure and Risk Assessment DP Number: 410739

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Page **26** of **34** 1500123000 15 Corn, field, starch 0.100000 1.000 0.100 1500123001 1 5 Corn, field, starch - babyfood 0.100000 1.000 0.100 1500124000 15 Corn, field, syrup 0.100000 1.500 0.100 1500124001 15 Corn, field, syrup - babyfood 0.100000 1.500 1.000 1500126000 15 Corn, pop 0.100000 1.000 1.000 1500127000 15 Corn, sweet 0.040000 1.000 0.050 1500127001 15 Corn, sweet - babyfood 0.040000 1.000 0.050 2003128000 20C Cottonseed, oil 0.300000 1.000 0.025 2003128001 20C Cottonseed, oil - babyfood 0.300000 1.000 0.025 1100129000 11 Crabapple 1.500000 1.000 1.000 0401133000 4A Cress, garden 11.770000 1.000 1.000 0401134000 4A Cress, upland 11.770000 1.000 1.000 0902135000 9B Cucumber 0.500000 1.000 0.050 1302136000 13B Currant 4.000000 1.000 1.000 1302137000 13B Currant, dried 4.000000 1.000 1.000 0401138000 4A Dandelion, leaves 11.770000 1.000 1.000 0103139000 1CD Dasheen, corm 0.040000 1.000 1.000 0200140000 2 Dasheen, leaves 16.000000 1.000 1.000 1902143000 19B Dill, seed 25.000000 1.000 1.000 1901144000 19A Dillweed 25.000000 1.000 1.000 7000146000 70 Egg, white 0.100000 1.000 1.000 70001460 01 70 Egg, white (solids) - babyfood 0.100000 1.000 1.000 7000145000 70 Egg, whole 0.100000 1.000 1.000 7000145001 70 Egg, whole - babyfood 0.100000 1.000 1.000 7000147000 70 Egg, yolk 0.100000 1.000 1.000 7000147001 70 Egg, yolk - babyfood 0.100000 1.000 1.000 0802148000 8BC Eggplant 1.400000 1.000 1.000 1302149000 13B Elderberry 4.00000 0 1.000 1.000 0401150000 4A Endive 11.770000 1.000 1.000 0402152000 4B Fennel, Florence 5.020000 1.000 1.000 2001163000 20A Flax seed, oil 0.450000 1.200 1.000 030116 5000 3A Garlic, bulb 0.900000 1.000 0.150 0301165001 3A Garlic, bulb - babyfood 0.900000 1.000 0.150 0103166000 1CD Ginger 0.040000 1.000 1.000 0103167000 1CD Ginger, dried 0.040000 1.000 1.000 0103166001 1CD Ginger - babyfood 0.040000 1.000 1.000 0101168000 1AB Ginseng, dried 0.400000 1.000 1.000 3200171000 32 Goat, fat 0.100 000 1.000 1.000 3200172000 32 Goat, kidney 0.200000 1.000 1.000 3200173000 32 Goat, liver 1.500000 1.000 1.000 3200169000 32 Goat, meat 0.100000 1.000 1.000 3200 170000 32 Goat, meat byproducts 0.200000 1.000 1.000 1100173500 11 Goji berry 1.500000 1.000 1.000 1302174000 13B Gooseberry 4.000000 1.000 1.000 1304175000 13D Grape 0.768000 1.000 0.300 1304176000 13D Grape, juice 0.768000 0.010 0.300 1304176001 13D Grape, juice - babyfood 0.768000 0.010 0.300 9500177000 O Grape, leaves 0.7 68000 1.000 0.300 9500178000 O Grape, raisin 0.768000 1.000 0.300 1304179000 13D Grape, wine and sherry 0.768000 1.000 0.300 1003180000 10C Grapefruit 2.000000 1.000 0.250 10 03181000 10C Grapefruit, juice 2.000000 0.020 0.250 0603182000 6C Guar, seed 0.500000 1.000 0.100 0603182001 6C Guar, seed - babyfood 0.500000 1.000 0.100Py

raclostrobin Dietary Exposure and Risk Assessment DP Number: 410739

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Page **27** of **34** 1400155000 14 Hazelnut 0.040000 1.000 0.150 1400156000 14 Hazelnut, oil 0.040000 1.000 1.000 1901184000 19A Herbs, other 25.000000 1.000 1.000 1901184001 19A Herbs, other - babyfood 25 .000000 1.000 1.000 1400185000 14 Hickory nut 0.040000 1.000 1.000 0901187000 9A Honeydew melon 0.500000 1.000 1.000 9500188000 O Hop 23.000000 1.000 1.000 3300189000 33 Horse, meat 0.100000 1.000 1.000 0101190000 1AB Horseradish 0.400000 1.000 1.000 1302191000 13B Huckleberry 4.000000 1.000 1.000 0502194000 5B Kale 16.000000 1.000 1.000 1304195000 13D Kiwifruit, fuzzy 0.768000 1.000 1.000 0501196000 5A Kohlrabi 5.000000 1.000 1.000 1002197000 10B Kumquat 2.000000 1.000 1.000 0302198000 3B Leek 0.900000 1.000 1.000 1002199000 10B Lemon 2.000000 1.000 0.025 1002200000 10B Lemon, juice 2.000000 0.020 0.025 1002200001 10B Lemon, juice - babyfood 2.000000 0.020 0.025 1002201000 10B Lemon, peel 2.000000 1.000 0.025 1901202000 19A Lemongrass 25.000000 1.000 1.000 0603203000 6C Lentil, seed 0.500000 1.000 0.100 0401204000 4A Lettuce, head 0.590000 1.000 0.050 0401205000 4A Lettuce, leaf 7.680000 1.000 0.050 1002206000 10B Lime 2.000000 1.000 1.000 1002207000 10B Lime, juice 2.000000 0.020 1.000 1002207001 10B Lime, juice - babyfood 2.000000 0.020 1.000 1301208000 13A Loganberry 4.000000 1.000 0.50 0 1100210000 11 Loquat 1.500000 1.000 1.000 1400213000 14 Macadamia nut 0.040000 1.000 1.000 9500215000 O Mango 0.600000 1.000 1.000 9500216000 O Mango , dried 0.600000 1.000 1.000 9500217000 O Mango, juice 0.600000 1.000 1.000 9500217001 O Mango, juice - babyfood 0.600000 1.000 1.000 9500215001 O Mango - babyfood 0.600000 1.000 1.000 1901220000 19A Marjoram 25.000000 1.000 1.000 1901220001 19A Marjoram - babyfood 25.000000 1.000 1.000 3600222000 36 Milk, fat 0.100000 1.000 1. 000 3600222001 36 Milk, fat - baby food/infant formu 0.100000 1.000 1.000 3600223000 36 Milk, nonfat solids 0.100000 1.000 1.000 3600223001 36 Milk, nonfat solids - baby food/in 0.100000 1.000 1.000 3600225001 36 Mil k, sugar (lactose) - baby food/ 0.100000 1.000 1.000 3600224000 36 Milk, water 0.100000 1.000 1.000 3600224001 36 Milk, water - babyfood/infant form 0.100000 1.000 1.000 1303227000 13C Mulberry 4.000000 1.000 1.000 0502229000 5B Mustard greens 5.740000 1.000 1.000 1202230000 12B Nectarine 0.602000 1.000 0.100 1500231000 15 Oat, bran 1.200000 1.000 1.000 1500232000 15 Oat, flour 1.200000 1.000 1.000 1500232001 15 Oat, flour - babyfood 1.200000 1.000 1.000 1500233000 15 Oat, groats/rolled oats 1.200000 1.000 1.000 1500233001 15 O at, groats/rolled oats - babyfood 1.200000 1.000 1.000 0802234000 8BC Okra 1.400000 1.000 1.000 0301237000 3A Onion, bulb 0.900000 1.000 0.200 0301238000 3A Onion, bulb, dried 0.900000 9.000 0.200Py

raclostrobin Dietary Exposure and Risk Assessment DP Number: 410739

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Page **28** of **34** 0301238001 3A Onion, bulb, dried - babyfood 0.900000 9.000 0.200 0301237001 3A Onion, bulb - babyfood 0.900000 1.000 0.200 0302239000 3B Onion, green 0.900000 1.000 0.200 1001240000 10A Orange 0.300000 1.000 0.050 1001241000 10A Orange, juice 0.300000 0.020 0.050 1001241001 10A Orange, juice - babyfood 0.300000 0.020 0.050 1001242000 10A Orange, peel 0.300000 1.000 0.050 9500245000 O Papaya 0.600000 1.000 1.000 9500246000 O Papaya, dried 0.600000 1.800 1.000 9500247000 O Papaya, juice 0.600000 1.500 1.000 9500245001 O Papaya - babyfood 0.600000 1.000 1.000 1901249000 19A Parsley, dried leaves 85.000000 1.000 1.000 1901249001 19A Parsley, dried leaves - babyfood 85.000000 1.0 00 1.000 0401248000 4A Parsley, leaves 11.770000 1.000 1.000 0101250000 1AB Parsley, turnip rooted 0.400000 1.000 1.000 0101251000 1AB Parsnip 0.400000 1.000 1.000 0101251001 1A B Parsnip - babyfood 0.400000 1.000 1.000 0603256000 6C Pea, dry 0.500000 1.000 0.100 0603256001 6C Pea, dry - babyfood 0.500000 1.000 0.100 0601257000 6A Pea, edible podded, su cculent 0.500000 1.000 1.000 0603258000 6C Pea, pigeon, seed 0.500000 1.000 0.100 0602259000 6B Pea, pigeon, succulent 0.200000 1.000 0.050 0602255000 6B Pea, succulent 0.200000 1 .000 0.050 0602255001 6B Pea, succulent - babyfood 0.200000 1.000 0.050 1202260000 12B Peach 0.602000 1.000 0.200 1202261000 12B Peach, dried 0.602000 7.000 0.200 1202261001 12B Peach, dried - babyfood 0.602000 7.000 0.200 1202262000 12B Peach, juice 0.602000 1.000 0.200 1202262001 12B Peach, juice - babyfood 0.602000 1.000 0.200 1202260001 12B Peach - babyfood 0.602000 1.000 0.200 9500263000 O Peanut 0.050000 1.000 0.250 9500264000 O Peanut, butter 0.050000 1.890 0.250 9500265000 O Peanut, oil 0.100000 1.000 0.250 1100266000 11 Pear 1.500000 1.000 0.150 1100267000 11 Pear, dried 1.500000 6.250 0.150 1100268000 11 Pear, juice 1.500000 1.000 0.150 110026800 1 11 Pear, juice - babyfood 1.500000 1.000 0.150 1100266001 11 Pear - babyfood 1.500000 1.000 0.150 1400269000 14 Pecan 0.040000 1.000 0.025 0802270000 8B Pepper, bell 1.400000 1.000 0.100 0802271000 8B Pepper, bell, dried 1.400000 1.000 0.100 0802271001 8B Pepper, bell, dried - babyfood 1.400000 1.000 0.100 0802272000 8BC Pepper, nonbell 1.400000 1.000 0.100 0802273000 8BC Pepper, nonbell, dried 1.400000 1.000 0.100 0802272001 8BC Pepper, nonbell - babyfood 1.400000 1.000 0.100 9500275000 O Peppermint 8.000000 1.000 1.000 9500276 000 O Peppermint, oil 8.000000 1.000 1.000 9500277000 O Persimmon 0.600000 1.000 1.000 1400278000 14 Pine nut 0.040000 1.000 1.000 1400282000 14 Pistachio 0.700000 1.000 0.300 9500283000 O Plantain 0.040000 1.000 1.000 9500284000 O Plantain, dried 0.040000 3.900 1.000 1203285000 12C Plum 0.1980 00 1.000 0.050 1203287000 12C Plum, prune, dried 0.198000 1.300 0.050Py

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Page **29** of **34** 1203287001 12C Plum, prune, dried - babyfood 0.198000 1.300 0.050 1203286000 12C Plum, prune, fresh 0.198000 1.000 0.050 12032 86001 12C Plum, prune, fresh - babyfood 0.198000 1.000 0.050 1203288000 12C Plum, prune, juice 0.198000 1.400 0.050 1203288001 12C Plum, prune, juice - babyfood 0.198000 1.400 0.050 1203285001 12C Plum - babyfood 0.198000 1.000 0.050 3400293000 34 Pork, fat 0.100000 1.000 1.000 3400293001 34 Pork, fat - babyfood 0.100000 1.000 1.000 3400294000 34 Pork, kidney 0.20 0000 1.000 1.000 3400295000 34 Pork, liver 1.500000 1.000 1.000 3400290000 34 Pork, meat 0.100000 1.000 1.000 3400292000 34 Pork, meat byproducts 0.200000 1.000 1.000 340 0292001 34 Pork, meat byproducts - babyfood 0.200000 1.000 1.000 3400290001 34 Pork, meat - babyfood 0.100000 1.000 1.000 3400291000 34 Pork, skin 0.100000 1.000 1.000 0103296000 1C Potato, chip s 0.040000 1.000 0.150 0103297000 1C Potato, dry (granules/ flakes) 0.040000 1.000 0.150 0103297001 1C Potato, dry (granules/ flakes) - b 0.040000 1.000 0.150 0103298000 1C Potato, flour 0. 040000 1.000 0.150 0103298001 1C Potato, flour - babyfood 0.040000 1.000 0.150 0103300000 1C Potato, tuber, w/o peel 0.040000 1.000 0.150 0103300001 1C Potato, tuber, w/o peel - babyfood 0.040000 1.000 0.150 0 103299000 1C Potato, tuber, w/peel 0.040000 1.000 0.150 0103299001 1C Potato, tuber, w/peel - babyfood 0.040000 1.000 0.150 6000304000 60 Poultry, other, fat 0.100000 1.000 1.000 6000302000 60 Poultry, o ther, liver 0.100000 1.000 1.000 6000301000 60 Poultry, other, meat 0.100000 1.000 1.000 6000303000 60 Poultry, other, meat byproducts 0.100000 1.000 1.000 6000305000 60 Poultry, other, skin 0.100000 1.000 1.000 1003307000 10C Pummelo 2.000000 1.000 1.000 0902308000 9B Pumpkin 0.500000 1.000 0.200 0902309000 9B Pumpkin, seed 0.500000 1.000 0.200 1100310000 11 Quince 1.500000 1.000 1.000 0401313000 4A Radicchio 0.590000 1.000 1.000 0101316000 1AB Radish, Oriental, roots 0.400000 1.000 1.000 0200317000 2 Radish, Oriental, tops 16.000000 1.000 1.000 0101314000 1AB Radish, roots 0.400000 1.000 1.000 0200315000 2 Radish, tops 16.000000 1.000 1.000 0502318000 5B Rape greens 16.000000 1.000 1.000 2001319000 20A Rapeseed, oil 0.450000 1.000 1.000 2001319001 20A Rapeseed, oil - babyfood 0.450000 1.000 1.000 1301320000 13A Raspberry 4.000000 1.000 0.500 1301321000 13A Raspberry, juice 4.000000 1.000 0.500 1301321001 13A Raspberry, juice - babyfood 4.000000 1.000 0.500 1301320001 13A Raspberry - babyfood 4.000000 1.000 0.500 0402322000 4B Rhubar b 5.020000 1.000 1.000 0101327000 1AB Rutabaga 0.400000 1.000 1.000 1500329000 15 Rye, flour 0.040000 1.000 1.000 1500328000 15 Rye, grain 0.040000 1.000 1.000 2002330000 20B Safflower, oil 0.450000 1.000 1.000 2002330001 20B Safflower, oil - babyfood 0.450000 1.000 1.000 0101331000 1AB Salsify, roots 0.400000 1.000 1.0 00 0200332000 2 Salsify, tops 16.000000 1.000 1.000 9500333000 O Sapote, Mamey 0.600000 1.000 1.000Py

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Page **30** of **34** 1901334000 19A Savory 25.000000 1.000 1.000 2001337000 20A Sesa me, oil 0.450000 1.000 1.000 2001337001 20A Sesame, oil - babyfood 0.450000 1.000 1.000 2001336000 20A Sesame, seed 0.450000 1.000 1.000 2001336001 20A Sesame, seed - babyfood 0.450000 1.000 1.000 0301338000 3A Shallot, bulb 0.900000 1.000 1.000 0302338500 3B Shallot, fresh leaves 0.900000 1.000 1.000 3500341000 35 Sheep, fat 0.100000 1.000 1 .000 3500341001 35 Sheep, fat - babyfood 0.100000 1.000 1.000 3500342000 35 Sheep, kidney 0.200000 1.000 1.000 3500343000 35 Sheep, liver 1.500000 1.000 1.000 3500339000 35 Sh eep, meat 0.100000 1.000 1.000 3500340000 35 Sheep, meat byproducts 0.200000 1.000 1.000 3500339001 35 Sheep, meat - babyfood 0.100000 1.000 1.000 1500344000 15 Sorghum, grain 0.090000 1.000 1.000 1500345000 15 Sorghum, syrup 0.090000 1.000 1.000 0603348000 6C Soybean, flour 0.040000 1.000 0.050 0603348001 6C Soybean, flour - babyfood 0.040000 1.000 0.050 0600350000 6 Soybean, oil 0.040000 1.000 0.050 0600350001 6 Soybean, oil - babyfood 0.040000 1.000 0.050 0600347000 6 Soybean, seed 0.040000 1.000 0.050 0600349000 6 Soybean, soy milk 0.040000 1.000 0.050 0600349001 6 Soybean, soy milk - babyfood or in 0.040000 1.000 0.050 9500352000 O Spearmint 8.000000 1.000 1.000 9500353000 O Spearmint, oil 8.000000 1.000 1.000 0401355000 4A Spinach 11.770000 1.000 0.050 0401355001 4A Spinach - babyfood 11.770000 1.000 0.050 0902356000 9B Squash, summer 0.500000 1.00 0 0.150 0902356001 9B Squash, summer - babyfood 0.500000 1.000 0.150 0902357000 9B Squash, winter 0.500000 1.000 0.150 0902357001 9B Squash, winter - babyfood 0.500000 1.000 0.150 1307359000 13G Strawberry 1.200000 1.000 0.650 1307360000 13G Strawberry, juice 1.200000 1.000 0.650 1307360001 13G Strawberry, juice - babyfood 1.200000 1.000 0.650 1307359001 13G Strawberry - babyfood 1.200000 1.000 0.650 9500363000 O Sugarcane, molasses 0.076000 0.150 1.000 9500363001 O Sugarcane, molasses - babyfood 0.076000 0.150 1.000 9500362000 O Sugarcane, sugar 0.076000 0. 150 1.000 9500362001 O Sugarcane, sugar - babyfood 0.076000 0.150 1.000 2002365000 20B Sunflower, oil 0.450000 1.000 1.000 2002365001 20B Sunflower, oil - babyfood 0.450000 1.000 1.000 2002364000 2 0B Sunflower, seed 0.450000 1.000 1.000 0103366000 1CD Sweet potato 0.040000 1.000 1.000 0103366001 1CD Sweet potato - babyfood 0.040000 1.000 1.000 0402367000 4B Swiss chard 5.020000 1.000 1.000 1001369000 10A Tangerine 2.000000 1.000 0.100 1001370000 10A Tangerine, juice 2.000000 0.020 0.100 0103371000 1CD Tanier, corm 0.040000 1.000 1.000 0801374000 8A Tomatillo 0.158000 1.000 1.000 0801375000 8A Tomato 0.158000 1.000 0.250 0801378000 8A Tomato, dried 0.158000 14.300 0.250 0801378001 8A Tomato, dried - babyfood 0.158000 14.300 0.250 0801379000 8A Tomato, juice 0.158000 1.500 0.250 0801376000 8A Tomato, paste 0.158000 2.100 0.250Py

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Page **31** of **34** 0801376001 8A Tomato, paste - babyf ood 0.158000 2.100 0.250 0801377000 8A Tomato, puree 0.158000 0.550 0.250 0801377001 8A Tomato, puree - babyfood 0.158000 0.550 0.250 0801375001 8A Tomato - babyfood 0.158000 1.000 0.250 1500381000 15 Triticale, flour 0.020000 0.700 1.000 1500381001 15 Triticale, flour - babyfood 0.020000 1.000 1.000 5000385000 50 Turkey, fat 0.100000 1.000 1.000 50003850 01 50 Turkey, fat - babyfood 0.100000 1.000 1.000 5000383000 50 Turkey, liver 0.100000 1.000 1.000 5000383001 50 Turkey, liver - babyfood 0.100000 1.000 1.000 5000382000 50 Turkey, meat 0.100000 1.000 1.000 5000384000 50 Turkey, meat byproducts 0.100000 1.000 1.000 5000384001 50 Turkey, meat byproducts - babyfood 0.100000 1.000 1.000 5000382001 50 Turkey, meat - babyfood 0.10000 0 1.000 1.000 5000386000 50 Turkey, skin 0.100000 1.000 1.000 5000386001 50 Turkey, skin - babyfood 0.100000 1.000 1.000 0103387000 1CD Turmeric 0.040000 1.000 1.000 050238 9000 5B Turnip, greens 16.000000 1.000 1.000 0101388000 1AB Turnip, roots 0.400000 1.000 1.000 1400391000 14 Walnut 0.040000 1.000 0.010 8601000000 86A Water, direct, all sources 0.002300 1.000 1.000 8602000000 86B Water, indirect, all sources 0.002300 1.000 1.000 0901399000 9A Watermelon 0.500000 1.000 0.300 0901400000 9A Watermelon, juice 0.500 000 1.000 0.300 1500404000 15 Wheat, bran 0.020000 1.000 0.050 1500402000 15 Wheat, flour 0.020000 0.700 0.050 1500402001 15 Wheat, flour - babyfood 0.020000 0.700 0.050 1500 403000 15 Wheat, germ 0.020000 0.850 0.050 1500401000 15 Wheat, grain 0.020000 1.000 0.050 1500401001 15 Wheat, grain - babyfood 0.020000 1.000 0.050 0103407000 1CD Yam bean 0.040000 1.000 1.000 0103406000 1CD Yam, true 0.040000 1.000 1.000Py

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### Attachment 4. Pyraclostrobin Chronic Dietary Analysis Results **– Food & Water**  US EPA Ver. 3.16, 03 - 08 - d DEEM - FCID Chronic analysis for PYRACLOSTROBIN NHANES 2003 - 2008 2 - day Residue file name: C: \ Documents and Settings \ sfunk \ My Documents \ DEEMversion3.16 \ PyracloChronic04_15_13.R08 Adjustment factor #2 used. Analysis Date 04 - 23 - 2013/07:12:23 Residue file dated: 04 - 23 - 2013/07:11:41 Reference dose (RfD, Chronic) = .034 mg/kg bw/day COMMENT 1: Food and drinking water

=========================================== ==================================== Total exposure by population subgroup

------------------------------------------------------------------------------- Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- ---------------- Total US Population 0.002707 8.0% Hispanic 0.002691 7.9% Non - Hisp - White 0.002669 7.8% Non - Hisp - Black 0.002711 8.0% Non - Hisp - Other 0.003270 9.6% Nursing Infants 0.002498 7.3% Non - Nursing Infants 0.005182 15.2% Female 13+ PREG 0.002189 6.4% Children 1 - 6 0.007078 20.8% Children 7 - 12 0.003255 9.6% Male 13 - 19 0.001989 5.8% Female 13 - 19/NP 0.001683 5.0% Male 20+ 0.002326 6.8% Female 20+/NP 0.002153 6.3% Seniors 55+ 0.002196 6.5% All Infants 0.004353 12.8% Female 13 - 50 0.002005 5.9% Children 1 - 2 0.009206 27.1% Children 3 - 5 0.006204 18.2% Children 6 - 12 0.003525 10.4% Youth 13 - 19 0.001832 5.4% Adults 20 - 49 0.002224 6.5% Adults 50 - 99 0.002252 6.6% Female 13 - 49 0.002005 5.9%Py

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### Attachment **5 . Pyraclostrobin**  **Screening Level Usage Analysis (SLUA)**Py

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