Exhibit 10.1 

      

      

      
        THIRD LEASE AMENDMENT

        

        

        This Lease Amendment made this 9th day of September, 2021 by and between DUKE & DUKE, a Limited Partnership,
          of 37000 Grand River Avenue, Suite 360, Farmington Hills, MI 48335, as “LANDLORD” and Ocuphire Pharma, Inc. of 37000 Grand River Avenue, Suite 120, Farmington Hills, MI 48335, as “TENANT’.

        

        

        WITNESSETH

        

        

        WHEREAS, on or about the 31st day of August, 2021, Landlord and Tenant
          entered into a Lease Agreement with a First Amendment on October 29, 2019, and a Second Amendment on November 17, 2020. The Lease together with any and all Amendments and/or riders is herein collectively referred to as, “Lease”. The certain
          demised premises consists of 1,623 rentable square feet and being commonly known as Suite 120 at 37000 Grand River Avenue, Farmington Hills, MI 48335; and

         

        WHEREAS, the parties wish to amend this Lease in respect to the demised premises in that Tenant will extend the term of the Lease; and

        

        

        NOW THEREFORE, in consideration of monies to be paid and covenants and conditions to be performed, IT IS HEREBY AGREED AS FOLLOWS:

        

        

        	

              	1.	
                That the rent for the Suite known as Suite 120 will be as follows;

              


         

        

        
          
            
              
                	 	
                        01/01/2022 – 12/31/2022

                      	
                        $22.00 per rentable square foot

                      


              

            

          

        


        

        

        	

              	2.	
                That the expiration date of Tenant’s Lease shall be December 31, 2022.

              


        

        

        
          
            
              	

                    	3.

                    	Tenant Share: 	2.13%


            

          

        

         

        

        
          
            	

                  	4.

                  	Base Tax:

                  	$1.39


          

        

        

        

        5.            Miscellaneous: The Lease remains in full force and effect and has not been
            modified or extended except as specifically set in this Third Amendment and extension of lease agreement. To the extent of any conflict between this Amendment and extension of lease agreement and the lease, the provisions of this Third
            Amendment shall control.

        

        

        	
                TENANT:

              	 	
                LANDLORD:

              	 
	 	 	 	 
	
                Ocuphire Pharma, Inc.

              	 	
                DUKE & DUKE,

              	 
	 	 	
                a Limited Partnership

              	 
	 	 	 	 
	
                /s/ Mina Sooch

              	 	
                /s/ Thomas Duke

              	 
	
                Name: Mina Sooch

              	 	
                Name: Thomas Duke

              	 
	
                Its: CEO

              	 	
                Its: Gen Ptnr

              	 
	
                Date: 9/9/2021

              	 	
                Date: 9/9/2021