Chemical-specific Inputs for EPA’s 2015 Final Updated Human Health Ambient Water Quality Criteria

1

Chemical Name CAS

Cancer Slope 

Factor, CSF

(per mg/kg-d)

Reference 

Dose, RfD

(mg/kg-d)

Relative Source 

Contribution, RSC 

(-)

Bioaccumulation Factor

Bioconcentration Factor

(L/kg tissue)

Trophic Level 2

(L/kg tissue)

Trophic Level 3

(L/kg tissue)

Trophic Level 4

(L/kg tissue)

1,1,1-Trichloroethane 71-55-6 ND 2 0.20 6.9 9.0 10 

1,1,2,2-Tetrachloroethane 79-34-5 0.2 0.02 0.20 5.7 7.4 8.4

1,1,2-Trichloroethane 79-00-5 0.057 0.004 0.20 6.0 7.8 8.9

1,1-Dichloroethylene 75-35-4 ND 0.05 0.20 2.0 2.4 2.6

1,2,4,5-Tetrachlorobenzene 95-94-3 ND 0.0003 0.20 17,000 2,900 1,500 

1,2,4-Trichlorobenzene 120-82-1 0.029 0.01 0.20 2,800 1,500 430 

1,2-Dichlorobenzene 95-50-1 ND 0.3 0.20 52 71 82 

1,2-Dichloroethane 107-06-2 0.0033 0.078 0.20 1.6 1.8 1.9

1,2-Dichloropropane 78-87-5 0.036 0.0893 0.20 2.9 3.5 3.9

1,2-Diphenylhydrazine 122-66-7 0.8 ND ND 18 24 27 

1,3-Dichlorobenzene 541-73-1 ND 0.002 0.20 31 120 190 

1,3-Dichloropropene 542-75-6 0.122 0.025 0.20 2.3 2.7 3.0

1,4-Dichlorobenzene 106-46-7 ND 0.07 0.20 28 66 84 

2,4,5-Trichlorophenol 95-95-4 ND 0.1 0.20 100 140 160 

2,4,6-Trichlorophenol 88-06-2 0.011 0.001 0.20 94 130 150 

2,4-Dichlorophenol 120-83-2 ND 0.003 0.20 31 42 48 

2,4-Dimethylphenol 105-67-9 ND 0.02 0.20 4.8 6.2 7.0

2,4-Dinitrophenol 51-28-5 ND 0.002 0.20 4.4* 4.4* 4.4*

2,4-Dinitrotoluene 121-14-2 0.667 0.002 0.20 2.8 3.5 3.9

2-Chloronaphthalene 91-58-7 ND 0.08 0.80 150 210 240 

2-Chlorophenol 95-57-8 ND 0.005 0.20 3.8 4.8 5.4

2-Methyl-4,6-Dinitrophenol 534-52-1 ND 0.0003 0.20 6.8 8.9 10 

3,3'-Dichlorobenzidine 91-94-1 0.45 ND ND 44 60 69 

3-Methyl-4-Chlorophenol 59-50-7 ND 0.1 0.20 25 34 39 

Acenaphthene 83-32-9 ND 0.06 0.20 510* 510* 510*

Acrolein 107-02-8 ND 0.0005 0.20 1.0 1.0 1.0

Acrylonitrile 107-13-1 0.54 ND ND 1.0 1.0 1.0
Chemical-specific Inputs for EPA’s 2015 Final Updated Human Health Ambient Water Quality Criteria

2

Chemical Name CAS

Cancer Slope 

Factor, CSF

(per mg/kg-d)

Reference 

Dose, RfD

(mg/kg-d)

Relative Source 

Contribution, RSC 

(-)

Bioaccumulation Factor

Bioconcentration Factor

(L/kg tissue)

Trophic Level 2

(L/kg tissue)

Trophic Level 3

(L/kg tissue)

Trophic Level 4

(L/kg tissue)

Aldrin 309-00-2 17 0.00003 0.20 18,000 310,000 650,000 

alpha-Hexachlorocyclohexane 

(HCH) 319-84-6 6.3 0.008 0.20 1,700 1,400 1,500 

alpha-Endosulfan 959-98-8 ND 0.006 0.20 130 180 200 

Anthracene 120-12-7 ND 0.3 0.20 610* 610* 610* 

Benzene 71-43-2 0.015 – 0.055 0.0005 0.20 3.6 4.5 5.0

Benzidine 92-87-5 230 0.003 0.20 1.4 1.6 1.7

Benzo(a)anthracene 56-55-3 0.73 ND ND 3,900* 3,900* 3,900* 

Benzo(a)pyrene 50-32-8 7.3 ND ND 3,900* 3,900* 3,900* 

Benzo(b)fluoranthene 205-99-2 0.73 ND ND 3,900* 3,900* 3,900* 

Benzo(k)fluoranthene 207-08-9 0.073 ND ND 3,900* 3,900* 3,900* 

beta-Hexachlorocyclohexane 

(HCH) 319-85-7 1.8 ND ND 110 160 180 

beta-Endosulfan 33213-65-9 ND 0.006 0.20 80 110 130 

Bis(2-Chloro-1-Methylethyl) Ether 108-60-1 ND 0.04 0.20 6.7 8.8 10 

Bis(2-Chloroethyl) Ether 111-44-4 1.1 ND ND 1.4 1.6 1.7

Bis(2-Ethylhexyl) Phthalate 117-81-7 0.014 0.06 0.20 710* 710* 710* 

Bis(Chloromethyl) Ether 542-88-1 220 ND ND 1.0 1.0 1.0

Bromoform 75-25-2 0.0045 0.03 0.20 5.8 7.5 8.5

Butylbenzyl Phthalate 85-68-7 0.0019 1.3 0.20 19,000* 19,000* 19,000* 

Carbon Tetrachloride 56-23-5 0.07 0.004 0.20 9.3 12 14 

Chlordane 57-74-9 0.35 0.0005 0.20 5,300 44,000 60,000 

Chlorobenzene 108-90-7 ND 0.02 0.20 14 19 22 

Chlorodibromomethane 124-48-1 0.040 0.02 0.20 3.7 4.8 5.3

Chloroform 67-66-3 ND 0.01 0.20 2.8 3.4 3.8

Chlorophenoxy Herbicide 

(2,4-D) 94-75-7 ND 0.21 0.20 13* 13* 13*

Chlorophenoxy Herbicide

(2,4,5-TP) [Silvex] 93-72-1 ND 0.008 0.80 58* 58* 58*
Chemical-specific Inputs for EPA’s 2015 Final Updated Human Health Ambient Water Quality Criteria

3

Chemical Name CAS

Cancer Slope 

Factor, CSF

(per mg/kg-d)

Reference 

Dose, RfD

(mg/kg-d)

Relative Source 

Contribution, RSC 

(-)

Bioaccumulation Factor

Bioconcentration Factor

(L/kg tissue)

Trophic Level 2

(L/kg tissue)

Trophic Level 3

(L/kg tissue)

Trophic Level 4

(L/kg tissue)

Chrysene 218-01-9 0.0073 ND ND 3,900* 3,900* 3,900* 

Cyanide 57-12-5 ND 0.0006 0.20 ND ND ND 1**

Dibenzo(a,h)anthracene 53-70-3 7.3 ND ND 3,900* 3,900* 3,900* 

Dichlorobromomethane 75-27-4 0.034 0.003 0.20 3.4 4.3 4.8

Dieldrin 60-57-1 16 0.00005 0.20 14,000 210,000 410,000 

Diethyl Phthalate 84-66-2 ND 0.8 0.20 920* 920* 920*

Dimethyl Phthalate 131-11-3 ND 10 0.20 4,000* 4,000* 4,000* 

Di-n-Butyl Phthalate 84-74-2 ND 0.1 0.20 2,900* 2,900* 2,900* 

Dinitrophenols 25550-58-7 ND 0.002 0.20 ND ND ND 1.51**

Endosulfan Sulfate 1031-07-8 ND 0.006 0.20 88 120 140 

Endrin 72-20-8 ND 0.0003 0.80 4,600 36,000 46,000 

Endrin Aldehyde 7421-93-4 ND 0.0003 0.80 440 920 850 

Ethylbenzene 100-41-4 ND 0.022 0.20 100 140 160 

Fluoranthene 206-44-0 ND 0.04 0.20 1,500* 1,500* 1,500* 

Fluorene 86-73-7 ND 0.04 0.20 230 450 710 

gamma- Hexachlorocyclohexane 

(HCH) 58-89-9 ND 0.0047 0.50 1,200 2,400 2,500 

Heptachlor 76-44-8 4.1 0.0001 0.20 12,000 180,000 330,000 

Heptachlor Epoxide 1024-57-3 5.5 0.000013 0.20 4,000 28,000 35,000 

Hexachlorobenzene 118-74-1 1.02 0.0008 0.20 18,000 46,000 90,000 

Hexachlorobutadiene 87-68-3 0.04 0.0003 0.20 23,000 2,800 1,100 

Hexachlorocyclohexane (HCH)-

Technical 608-73-1 1.8 ND ND 160 220 250 

Hexachlorocyclopentadiene 77-47-4 ND 0.006 0.20 620 1,500 1,300 

Hexachloroethane 67-72-1 0.04 0.0007 0.20 1,200 280 600 

Indeno(1,2,3-cd)pyrene 193-39-5 0.73 ND ND 3,900* 3,900* 3,900* 

Isophorone 78-59-1 0.00095 0.2 0.20 1.9 2.2 2.4

Methoxychlor 72-43-5 ND 0.00002 0.80 1,400 4,800 4,400 
Chemical-specific Inputs for EPA’s 2015 Final Updated Human Health Ambient Water Quality Criteria

4

Chemical Name CAS

Cancer Slope 

Factor, CSF

(per mg/kg-d)

Reference 

Dose, RfD

(mg/kg-d)

Relative Source 

Contribution, RSC 

(-)

Bioaccumulation Factor

Bioconcentration Factor

(L/kg tissue)

Trophic Level 2

(L/kg tissue)

Trophic Level 3

(L/kg tissue)

Trophic Level 4

(L/kg tissue)

Methyl Bromide 74-83-9 ND 0.02 0.20 1.2 1.3 1.4

Methylene Chloride 75-09-2 0.002 0.006 0.20 1.4 1.5 1.6

Nitrobenzene 98-95-3 ND 0.002 0.20 2.3 2.8 3.1

Pentachlorobenzene 608-93-5 ND 0.0008 0.20 3,500 4,500 10,000 

Pentachlorophenol 87-86-5 0.4 0.005 0.20 44 290 520 

Phenol 108-95-2 ND 0.6 0.20 1.5 1.7 1.9

p,p'-Dichlorodiphenyldichloroethane

(DDD) 72-54-8 0.24 0.0005 0.20 33,000 140,000 240,000 

p,p'-

Dichlorodiphenyldichloroethylene

(DDE)

72-55-9

0.167 0.0005 0.20 270,000 1,100,000 3,100,000 

p,p'-Dichlorodiphenyltrichloroethane

(DDT) 50-29-3 0.34 0.0005 0.20 35,000 240,000 1,100,000 

Pyrene 129-00-0 ND 0.03 0.20 860* 860* 860*

Tetrachloroethylene

(Perchloroethylene) 127-18-4 0.0021 0.006 0.20 49 66 76 

Toluene 108-88-3 ND 0.0097 0.20 11 15 17 

Toxaphene 8001-35-2 1.1 0.00035 0.20 1,700 6,600 6,300 

trans-1,2-Dichloroethylene (DCE) 156-60-5 ND 0.02 0.20 3.3 4.2 4.7

Trichloroethylene (TCE) 79-01-6 0.05 0.0005 0.20 8.7 12 13 

Vinyl Chloride 75-01-4 1.5 0.003 0.20 1.4 1.6 1.7

ND = No data.

* This bioaccumulation factor was estimated from laboratory-measured bioconcentration factors; EPA multiplied this bioaccumulation factor by the overall national 

recommended fish consumption rate of 22.0 g/d (see EPA’s 2014 Estimated Fish Consumption Rates for the U.S. Population and Selected Subpopulations (NHANES 2003-2010)) 

to calculate the 2015 final updated human health criteria.

** EPA multiplied this bioconcentration factor by the overall national recommended fish consumption rate of 22.0 g/d (see EPA’s 2014 Estimated Fish Consumption Rates for the 

U.S. Population and Selected Subpopulations (NHANES 2003-2010)) to calculate the 2015 final updated human health criteria.