EX-10.1






Exhibit 10.1




CYTOKINETICS, INCORPORATED




2004 EQUITY INCENTIVE PLAN




(as amended and restated as of May 22,2008)




1. Purposes of the Plan.  The purposes of this Plan are:



	 	 	 
	•

	 	to attract and retain the best available personnel for positions of substantial responsibility,
	•

	 	to provide additional incentive to Employees, Directors and Consultants, and
	•

	 	to promote the success of the Company’s business.






The Plan permits the grant of Incentive Stock Options, Nonstatutory Stock Options, Restricted
Stock, Stock Appreciation Rights, Performance Units and Performance Shares.



2. Definitions.  As used herein, the following definitions will apply:




(a) “Administrator” means the Board or any of its Committees as will be
administering the Plan, in accordance with Section 4 of the Plan.




(b) “Affiliated SAR” means an SAR that is granted in connection with a related
Option, and which automatically will be deemed to be exercised at the same time that the related
Option is exercised.




(c) “Applicable Laws” means the requirements relating to the administration of
equity-based awards under U.S. state corporate laws, U.S. federal and state securities laws, the
Code, any stock exchange or quotation system on which the Common Stock is listed or quoted and
the applicable laws of any foreign country or jurisdiction where Awards are, or will be, granted
under the Plan.




(d) “Approval Authority” means an authority, governmental or otherwise, that
regulates pre-market approval of goods and services.




(e) “Award”  means, individually or collectively, a grant under the Plan of Options,
SARs, Restricted Stock, Performance Units or Performance Shares.




(f) “Award Agreement” means the written or electronic agreement setting forth the
terms and provisions applicable to each Award granted under the Plan. The Award Agreement is
subject to the terms and conditions of the Plan.




(g) “Board”  means the Board of Directors of the Company.




(h) “Cash Position” means the Company’s or a business unit’s level of cash, cash
equivalents, and available for sale marketable securities.




(i) “Change in Control” means the occurrence of any of the following events:




(i) Any “person” (as such term is used in Sections 13(d) and 14(d) of the Exchange Act)
becomes the “beneficial owner” (as defined in Rule 13d-3 of the Exchange Act), directly or
indirectly, of securities of the Company representing fifty percent (50%) or more of the total
voting power represented by the Company’s then outstanding voting securities; or




(ii) The consummation of the sale or disposition by the Company of all or substantially
all of the Company’s assets;




(iii) A change in the composition of the Board occurring within a two-year period, as a
result of which fewer than a majority of the directors are Incumbent Directors. “Incumbent
Directors” means directors who either (A) are Directors as of the effective date of the Plan,
or (B) are elected, or nominated for election, to the Board with the affirmative votes of at
least a majority of the Incumbent Directors at the time of such election or nomination (but
will not include an individual whose election or nomination is in connection with an actual or
threatened proxy contest relating to the election of directors to the Company); or




(iv) The consummation of a merger or consolidation of the Company with any other
corporation, other than a merger or consolidation which would result in the voting securities
of the Company outstanding immediately prior thereto continuing to represent (either by
remaining outstanding or by being converted into voting securities of the surviving entity or
its parent) at least fifty percent (50%) of the total voting power represented by the voting
securities of the Company or such surviving entity or its parent outstanding immediately after
such merger or consolidation.




(j) “Clinical Progression” means, for any Performance Period, a Product’s entry into
or completion of a phase of clinical development, such as when a Product enters into or completes
a Phase 1, Phase 2, Phase 3 or other clinical study.




(k) “Code” means the Internal Revenue Code of 1986, as amended. Any reference to a
section of the Code herein will be a reference to any successor or amended section of the Code.




(l) “Collaboration Arrangement” means, for any Performance Period, entry into an
agreement or arrangement with a third party for the development, commercialization, marketing or
distribution of a Product or for the conducting of a research program to discover or develop a
Product or technologies.




(m) “Collaboration Progression” means, for any Performance Period, an event that
triggers an obligation or payment right to accrue under a Collaboration Agreement.




(n) “Committee” means a committee of Directors appointed by the Board in accordance
with Section 4 of the Plan.




(o) “Common Stock” means the common stock of the Company.




(p) “Company” means Cytokinetics, Incorporated, a Delaware corporation, or any
successor thereto.




(q) “Consultant” means any person, including an advisor, engaged by the Company or a
Parent or Subsidiary to render services to such entity.




(r) “Determination Date” means the latest possible date that will not jeopardize the
qualification of an Award granted under the Plan as “performance-based compensation” under
Section 162(m) of the Code.




(s) “Director”  means a member of the Board.




(t) “Disability”  means total and permanent disability as defined in
Section 22(e)(3) of the Code, provided that in the case of Awards other than Incentive Stock
Options, the Administrator in its discretion may determine whether a permanent and total
disability exists in accordance with uniform and non-discriminatory standards adopted by the
Administrator from time to time.




(u) “Earnings Per Share” means as to any Performance Period, the Company’s or a
business unit’s Net Income, divided by a weighted average number of common shares outstanding and
dilutive common equivalent shares deemed outstanding, determined in accordance with generally
accepted accounting principles.




(v) “Employee” means any person, including Officers and Directors, employed by the
Company or any Parent or Subsidiary of the Company. Neither service as a Director nor payment of
a director’s fee by the Company will be sufficient to constitute “employment” by the Company.




(w) “Exchange Act” means the Securities Exchange Act of 1934, as amended.




(x) “Exchange Program” means a program under which (i) outstanding Awards are
surrendered or cancelled in exchange for Awards of the same type (which may have lower exercise
prices and different terms), Awards of a different type, and/or cash, (ii) Participants would
have the opportunity to transfer any outstanding Awards to a financial institution or other
person or entity selected by the Administrator, and/or (iii) the exercise price of an outstanding
Award is reduced. The Administrator will determine the terms and conditions of any Exchange
Program in its sole discretion, subject to the provisions of Section 4(c).




(y) “Fair Market Value” means, as of any date, the value of Common Stock determined
as follows:




(i) If the Common Stock is listed on any established stock exchange or a national market
system, including without limitation the Nasdaq Global Market, the Nasdaq Global Select Market
or the Nasdaq Capital Market, its Fair Market Value will be the closing sales price for such
stock (or the closing bid, if no sales were reported) as quoted on such exchange or system on
the day of determination, as reported in The Wall Street Journal or such other source as the
Administrator deems reliable;




(ii) If the Common Stock is regularly quoted by a recognized securities dealer but selling
prices are not reported, the Fair Market Value of a Share of Common Stock will be the mean
between the high bid and low asked prices for the Common Stock on the day of determination, as
reported in The Wall Street Journal or such other source as the Administrator deems
reliable; or




(iii) In the absence of an established market for the Common Stock, the Fair Market Value
will be determined in good faith by the Administrator.




(z) “Financing Event” means, for any Performance Period, the closing of any
financing event for capital raising purposes.




(aa) “Fiscal Year” means the fiscal year of the Company.




(bb) “Freestanding SAR” means an SAR that is granted independently of any Option.




(cc) “Incentive Stock Option” means an Option intended to qualify as an incentive
stock option within the meaning of Section 422 of the Code and the regulations promulgated
thereunder.




(dd) “Net Income” means as to any Performance Period, the income after taxes of the
Company or a business unit for the Performance Period determined in accordance with generally
accepted accounting principles.




(ee) “Nonstatutory Stock Option” means an Option that by its terms does not qualify
or is not intended to qualify as an Incentive Stock Option.




(ff) “Officer” means a person who is an officer of the Company within the meaning of
Section 16 of the Exchange Act and the rules and regulations promulgated thereunder.




(gg) “Operating Cash Flow” means the Company’s or a business unit’s sum of Net
Income plus depreciation and amortization less capital expenditures plus changes in working
capital comprised of accounts receivable, inventories, other current assets, trade accounts
payable, accrued expenses, product warranty, advance payments from customers and long-term
accrued expenses, determined in accordance with generally acceptable accounting principles.




(hh) “Operating Expenses” means the sum of the Company’s or a business unit’s
research and development expenses and selling and general and administrative expenses during a
Performance Period.




(ii) “Operating Income” means the Company’s or a business unit’s income from
operations determined in accordance with generally accepted accounting principles.




(jj) “Option” means a stock option granted pursuant to the Plan.




(kk) “Outside Director” means a Director who is not an Employee.




(ll) “Parent” means a “parent corporation,” whether now or hereafter existing, as
defined in Section 424(e) of the Code.




(mm) “Participant” means the holder of an outstanding Award.




(nn) “Performance Period” means any Fiscal Year or such other period as determined
by the Administrator in its sole discretion.




(oo) “Performance Share” means an Award granted to a Participant pursuant to
Section 9.




(pp) “Performance Unit” means an Award granted to a Participant pursuant to
Section 9.




(qq) “Period of Restriction” means the period during which the transfer of Shares of
Restricted Stock are subject to restrictions and therefore, the Shares are subject to a
substantial risk of forfeiture. Such restrictions may be based on the passage of time, the
achievement of target levels of performance, or the occurrence of other events as determined by
the Administrator.




(rr) “Plan” means this 2004 Equity Incentive Plan.




(ss) “Product” means any drug candidate or product candidate requiring pre-market
approval by an Approval Authority.




(tt) “Product Approval” means the approval by any Approval Authority of the right to
market or sell a Product.




(uu) “Product Revenues” means as to any Performance Period, the Company’s or a
business unit’s sales, royalties, license fees, milestones and related-party revenues, determined
in accordance with generally accepted accounting principles.




(vv) “Profit After Tax” means as to any Performance Period, the Company’s or a
business unit’s income after taxes, determined in accordance with generally accepted accounting
principles.




(ww) “Projects in Development” refers to one or more projects at any or all stages
of development from conception, discovery, and/or initial research through Product Approval,
including, but not limited to, pre-clinical studies, filing of an investigational new drug
application (IND) or foreign equivalent, Phase 1, Phase 2, and Phase 3 clinical trials and
submission and approval of a new drug application (NDA) or foreign equivalent.




(xx) “Regulatory Filings” means as to any Performance Period, filings submitted to
an Approval Authority with respect to a Product for which the Company is pursuing Product
Approval.




(yy) “Restricted Stock” means shares of Common Stock issued pursuant to a Restricted
Stock award under Section 7 of the Plan, or issued pursuant to the early exercise of an Option.




(zz) “Return on Assets” means as to any Performance Period, the percentage equal to
the Company’s or a business unit’s Operating Income before incentive compensation, divided by
average net Company or business unit, as applicable, assets, determined in accordance with
generally accepted accounting principles.




(aaa) “Return on Equity” means as to any Performance Period, the percentage equal to
the Company’s Profit After Tax divided by average stockholder’s equity, determined in accordance
with generally accepted accounting principles.




(bbb) “Revenue Growth” means as to any Performance Period, the Company’s or a
business unit’s net sales determined in accordance with generally accepted accounting principles,
compared to the net sales of the immediately preceding quarter.




(ccc) “Rule 16b-3” means Rule 16b-3 of the Exchange Act or any successor to
Rule 16b-3, as in effect when discretion is being exercised with respect to the Plan.




(ddd) “Section 16(b)” means Section 16(b) of the Exchange Act.




(eee) “Service Provider” means an Employee, Director or Consultant.




(fff) “Share” means a share of the Common Stock, as adjusted in accordance with
Section 13 of the Plan.




(ggg) “Stock Appreciation Right” or “SAR” means an Award, granted alone or
in connection with an Option, that pursuant to Section 8 is designated as a SAR.




(hhh) “Subsidiary” means a “subsidiary corporation”, whether now or hereafter
existing, as defined in Section 424(f) of the Code.




(iii) “Tandem SAR” means an SAR that is granted in connection with a related Option,
the exercise of which will require forfeiture of the right to purchase an equal number of Shares
under the related Option (and when a Share is purchased under the Option, the SAR will be
canceled to the same extent).




(jjj) “Total Stockholder Return” means the total return (change in share price plus
reinvestment of any dividends) of a share of Common Stock.



3. Stock Subject to the Plan.




(a) Stock Subject to the Plan.  Subject to the provisions of Section 13 of the Plan,
the maximum aggregate number of Shares that may be optioned and sold under the Plan is
(A) 8,817,040 Shares plus (B) any Shares returned on or after February 29, 2008 to the 1997 Stock
Option/Stock Issuance Plan as a result of termination of options or repurchase of Shares issued
under such plan up to a maximum of 1,220,000 Shares. The Shares may be authorized, but unissued,
or reacquired Common Stock.




(b) Full Value Awards.  Any Shares subject to Awards granted with an exercise price
less than the Fair Market Value on the date of grant of such Awards will be counted against the
numerical limits of this Section 3 as two Shares for every one Share subject thereto. Further, if
Shares acquired pursuant to any such Award are forfeited or repurchased by the Company and would
otherwise return to the Plan pursuant to Section 3(c), two times the number of Shares so
forfeited or repurchased will return to the Plan and will again become available for issuance.




(c) Lapsed Awards.  If an Award expires or becomes unexercisable without having been
exercised in full, or, with respect to Restricted Stock, Performance Shares or Performance Units,
is forfeited to or repurchased by the Company, the unpurchased Shares (or for Awards other than
Options and Stock Appreciation Rights, the forfeited or repurchased Shares) which were subject
thereto will become available for future grant or sale under the Plan (unless the Plan has
terminated). Upon exercise of a Stock Appreciation Right settled in Shares, the gross number of
Shares covered by the portion of the Award so exercised will cease to be available under the
Plan. If the exercise price of an Option is paid by tender to the Company, or attestation to the
ownership, of Shares owned by the Participant, the number of Shares available for issuance under
the Plan will be reduced by the gross number of Shares for which the Option is exercised. Shares
that have actually been issued under the Plan under any Award will not be returned to the Plan
and will not become available for future distribution under the Plan; provided, however, that if
unvested Shares of Restricted Stock, Performance Shares or Performance Units are repurchased by
the Company or are forfeited to the Company, such Shares will become available for future grant
under the Plan. Shares used to pay the tax and exercise price of an Award will not become
available for future grant or sale under the Plan. To the extent an Award under the Plan is paid
out in cash rather than Shares, such cash payment will not result in reducing the number of
Shares available for issuance under the Plan. Notwithstanding the foregoing provisions of this
Section 3(c), subject to adjustment provided in Section 13, the maximum number of Shares that may
be issued upon the exercise of Incentive Stock Options will equal the aggregate Share number
stated in Section 3(a), plus, to the extent allowable under Section 422 of the Code, any Shares
that become available for issuance under the Plan under this Section 3(c).




(d) Share Reserve.  The Company, during the term of this Plan, will at all times
reserve and keep available such number of Shares as will be sufficient to satisfy the
requirements of the Plan.



4. Administration of the Plan.




	 	 	 	(a) Procedure.






(i) Multiple Administrative Bodies.  Different Committees with respect to
different groups of Service Providers may administer the Plan.




(ii) Section 162(m).  To the extent that the Administrator determines it to be
desirable to qualify Awards granted hereunder as “performance-based compensation” within the
meaning of Section 162(m) of the Code, the Plan will be administered by a Committee of two or
more “outside directors” within the meaning of Section 162(m) of the Code.




(iii) Rule 16b-3.  To the extent desirable to qualify transactions hereunder as
exempt under Rule 16b-3, the transactions contemplated hereunder will be structured to satisfy
the requirements for exemption under Rule 16b-3.




(iv) Other Administration.  Other than as provided above, the Plan will be
administered by (A) the Board or (B) a Committee, which committee will be constituted to
satisfy Applicable Laws.




(b) Powers of the Administrator.  Subject to the provisions of the Plan, and in the
case of a Committee, subject to the specific duties delegated by the Board to such Committee, the
Administrator will have the authority, in its discretion:




(i) to determine the Fair Market Value;




(ii) to select the Service Providers to whom Awards may be granted hereunder;




(iii) to determine the number of Shares to be covered by each Award granted hereunder;




(iv) to approve forms of agreement for use under the Plan;




(v) to determine the terms and conditions of any, and with the approval of the Company’s
stockholders, to institute an Exchange Program;




(vi) to determine the terms and conditions, not inconsistent with the terms of the Plan,
of any Award granted hereunder. Such terms and conditions include, but are not limited to, the
exercise price, the time or times when Awards may be exercised (which may be based on
performance criteria), any vesting acceleration or waiver of forfeiture restrictions, and any
restriction or limitation regarding any Award or the Shares relating thereto, based in each
case on such factors as the Administrator will determine;




(vii) to construe and interpret the terms of the Plan and Awards granted pursuant to the
Plan;




(viii) to prescribe, amend and rescind rules and regulations relating to the Plan,
including rules and regulations relating to sub-plans established for the purpose of satisfying
applicable foreign laws;




(ix) to modify or amend each Award (subject to Section 18(c) of the Plan), including the
discretionary authority to extend the post-termination exercisability period of Awards longer
than is otherwise provided for in the Plan;




(x) to allow Participants to satisfy withholding tax obligations by electing to have the
Company withhold from the Shares to be issued upon exercise of an Award that number of Shares
having a Fair Market Value equal to the minimum amount required to be withheld (the Fair Market
Value of the Shares to be withheld will be determined on the date that the amount of tax to be
withheld is to be determined and all elections by a Participant to have Shares withheld for
this purpose will be made in such form and under such conditions as the Administrator may deem
necessary or advisable);




(xi) to authorize any person to execute on behalf of the Company any instrument required
to effect the grant of an Award previously granted by the Administrator;




(xii) to allow a Participant to defer the receipt of the payment of cash or the delivery
of Shares that would otherwise be due to such Participant under an Award




(xiii) to make all other determinations deemed necessary or advisable for administering
the Plan.




(c) Prohibition Against Repricing.  Subject to adjustments made pursuant to
Section 13, in no event shall the Administrator have the right to amend the terms of any Award to
reduce the exercise price of such outstanding Award or cancel an outstanding Award in exchange
for cash or other Awards with an exercise price that is less than the exercise price of the
original Award without stockholder approval.




(d) Effect of Administrator’s Decision.  The Administrator’s decisions,
determinations and interpretations will be final and binding on all Participants and any other
holders of Awards.



5. Eligibility.  Nonstatutory Stock Options, Restricted Stock, Stock Appreciation
Rights, Performance Units and Performance Shares may be granted to Service Providers. Incentive
Stock Options may be granted only to Employees.



6. Stock Options.  



(a) Limitations.




(i) Each Option will be designated in the Award Agreement as either an Incentive Stock
Option or a Nonstatutory Stock Option. However, notwithstanding such designation, to the extent
that the aggregate Fair Market Value of the Shares with respect to which Incentive Stock Options
are exercisable for the first time by the Participant during any calendar year (under all plans
of the Company and any Parent or Subsidiary) exceeds $100,000, such Options will be treated as
Nonstatutory Stock Options. For purposes of this Section 6(a), Incentive Stock Options will be
taken into account in the order in which they were granted. The Fair Market Value of the Shares
will be determined as of the time the Option with respect to such Shares is granted.




(ii) The following limitations will apply to grants of Options:




(1) No Service Provider will be granted, in any Fiscal Year, Options to purchase more than
1,500,000 Shares.




(2) In connection with his or her initial service, a Service Provider may be granted
Options to purchase up to an additional 1,500,000 Shares, which will not count against the
limit set forth in Section 6(a)(ii)(1) above.




(3) The foregoing limitations will be adjusted proportionately in connection with any
change in the Company’s capitalization as described in Section 13.




(4) If an Option is cancelled in the same Fiscal Year in which it was granted (other than
in connection with a transaction described in Section 13), the cancelled Option will be counted
against the limits set forth in subsections (1) and (2) above.



(b) Term of Option.  The term of each Option will be stated in the Award Agreement. In
the case of an Incentive Stock Option, the term will be ten (10) years from the date of grant or
such shorter term as may be provided in the Award Agreement. Moreover, in the case of an Incentive
Stock Option granted to a Participant who, at the time the Incentive Stock Option is granted, owns
stock representing more than ten percent (10%) of the total combined voting power of all classes of
stock of the Company or any Parent or Subsidiary, the term of the Incentive Stock Option will be
five (5) years from the date of grant or such shorter term as may be provided in the Award
Agreement.



(c) Option Exercise Price and Consideration.  



(i) Exercise Price.  The per share exercise price for the Shares to be issued pursuant
to exercise of an Option will be determined by the Administrator, subject to the following:




(1) In the case of an Incentive Stock Option




a) granted to an Employee who, at the time the Incentive Stock Option is granted, owns
stock representing more than ten percent (10%) of the voting power of all classes of stock of
the Company or any Parent or Subsidiary, the per Share exercise price will be no less than 110%
of the Fair Market Value per Share on the date of grant.




b) granted to any Employee other than an Employee described in paragraph (A) immediately
above, the per Share exercise price will be no less than 100% of the Fair Market Value per
Share on the date of grant.




c) Notwithstanding the foregoing, Incentive Stock Options may be granted with a per Share
exercise price of less than 100% of the Fair Market Value per Share on the date of grant
pursuant to a transaction described in, and in a manner consistent with, Section 424(a) of the
Code.




(2) In the case of a Nonstatutory Stock Option, the per Share exercise price will be
determined by the Administrator. In the case of a Nonstatutory Stock Option intended to qualify
as “performance-based compensation” within the meaning of Section 162(m) of the Code, the per
Share exercise price will be no less than 100% of the Fair Market Value per Share on the date of
grant.



(ii) Waiting Period and Exercise Dates.  At the time an Option is granted, the
Administrator will fix the period within which the Option may be exercised and will determine any
conditions that must be satisfied before the Option may be exercised.



(iii) Form of Consideration.  The Administrator will determine the acceptable form of
consideration for exercising an Option, including the method of payment. In the case of an
Incentive Stock Option, the Administrator will determine the acceptable form of consideration at
the time of grant. Such consideration may consist entirely of: (1) cash; (2) check; (3) promissory
note; (4) other Shares, provided that such Shares have a Fair Market Value on the date of surrender
equal to the aggregate exercise price of the Shares as to which said Option will be exercised and
provided that accepting such Shares, in the sole discretion of the Administrator, shall not result
in any adverse accounting consequences to the Company; (5) consideration received by the Company
under a cashless exercise program implemented by the Company in connection with the Plan; (6) a
reduction in the amount of any Company liability to the Participant, including any liability
attributable to the Participant’s participation in any Company-sponsored deferred compensation
program or arrangement; (7) such other consideration and method of payment for the issuance of
Shares to the extent permitted by Applicable Laws; or (8) any combination of the foregoing methods
of payment.



(d) Exercise of Option.



(i) Procedure for Exercise; Rights as a Stockholder.  Any Option granted hereunder
will be exercisable according to the terms of the Plan and at such times and under such conditions
as determined by the Administrator and set forth in the Award Agreement. An Option may not be
exercised for a fraction of a Share.



An Option will be deemed exercised when the Company receives: (i) written or electronic notice
of exercise (in accordance with the Award Agreement) from the person entitled to exercise the
Option, and (ii) full payment for the Shares with respect to which the Option is exercised. Full
payment may consist of any consideration and method of payment authorized by the Administrator and
permitted by the Award Agreement and the Plan. Shares issued upon exercise of an Option will be
issued in the name of the Participant or, if requested by the Participant, in the name of the
Participant and his or her spouse. Until the Shares are issued (as evidenced by the appropriate
entry on the books of the Company or of a duly authorized transfer agent of the Company), no right
to vote or receive dividends or any other rights as a stockholder will exist with respect to the
Shares, notwithstanding the exercise of the Option. The Company will issue (or cause to be issued)
such Shares promptly after the Option is exercised. No adjustment will be made for a dividend or
other right for which the record date is prior to the date the Shares are issued, except as
provided in Section 13 of the Plan.



Exercising an Option in any manner will decrease the number of Shares thereafter available,
both for purposes of the Plan and for sale under the Option, by the number of Shares as to which
the Option is exercised.



(ii) Termination of Relationship as a Service Provider.  If a Participant ceases to be
a Service Provider, other than upon the Participant’s death or Disability, the Participant may
exercise his or her Option within such period of time as is specified in the Award Agreement to the
extent that the Option is vested on the date of termination (but in no event later than the
expiration of the term of such Option as set forth in the Award Agreement). In the absence of a
specified time in the Award Agreement, the Option will remain exercisable for three (3) months
following the Participant’s termination. Unless otherwise provided by the Administrator, if on the
date of termination the Participant is not vested as to his or her entire Option, the Shares
covered by the unvested portion of the Option will revert to the Plan. If after termination the
Participant does not exercise his or her Option within the time specified by the Administrator, the
Option will terminate, and the Shares covered by such Option will revert to the Plan.



(iii) Disability of Participant.  If a Participant ceases to be a Service Provider as
a result of the Participant’s Disability, the Participant may exercise his or her Option within
such period of time as is specified in the Award Agreement to the extent the Option is vested on
the date of termination (but in no event later than the expiration of the term of such Option as
set forth in the Award Agreement). In the absence of a specified time in the Award Agreement, the
Option will remain exercisable for twelve (12) months following the Participant’s termination.
Unless otherwise provided by the Administrator, if on the date of termination the Participant is
not vested as to his or her entire Option, the Shares covered by the unvested portion of the Option
will revert to the Plan. If after termination the Participant does not exercise his or her Option
within the time specified herein, the Option will terminate, and the Shares covered by such Option
will revert to the Plan.



(iv) Death of Participant.  If a Participant dies while a Service Provider, the Option
may be exercised following the Participant’s death within such period of time as is specified in
the Award Agreement to the extent that the Option is vested on the date of death (but in no event
may the option be exercised later than the expiration of the term of such Option as set forth in
the Award Agreement), by the Participant’s designated beneficiary, provided such beneficiary has
been designated prior to Participant’s death in a form acceptable to the Administrator. If no such
beneficiary has been designated by the Participant, then such Option may be exercised by the
personal representative of the Participant’s estate or by the person(s) to whom the Option is
transferred pursuant to the Participant’s will or in accordance with the laws of descent and
distribution. In the absence of a specified time in the Award Agreement, the Option will remain
exercisable for twelve (12) months following Participant’s death. Unless otherwise provided by the
Administrator, if at the time of death Participant is not vested as to his or her entire Option,
the Shares covered by the unvested portion of the Option will immediately revert to the Plan. If
the Option is not so exercised within the time specified herein, the Option will terminate, and the
Shares covered by such Option will revert to the Plan.



7. Restricted Stock.



(a) Grant of Restricted Stock. Subject to the terms and provisions of the Plan, the
Administrator, at any time and from time to time, may grant Shares of Restricted Stock to Service
Providers in such amounts as the Administrator, in its sole discretion, will determine.



(b) Restricted Stock Agreement.  Each Award of Restricted Stock will be evidenced by
an Award Agreement that will specify the Period of Restriction, the number of Shares granted, and
such other terms and conditions as the Administrator, in its sole discretion, will determine.
Notwithstanding the foregoing sentence, for Restricted Stock intended to qualify as
“performance-based compensation” within the meaning of Section 162(m) of the Code, during any
Fiscal Year no Participant will receive more than an aggregate of 1,000,000 Shares of Restricted
Stock. Notwithstanding the foregoing limitation, in connection with his or her initial service as
an Employee, for Restricted Stock intended to qualify as “performance-based compensation” within
the meaning of Section 162(m) of the Code, an Employee may be granted an aggregate of up to an
additional 1,000,000 Shares of Restricted Stock. Unless the Administrator determines otherwise,
Shares of Restricted Stock will be held by the Company as escrow agent until the restrictions on
such Shares have lapsed.



(c) Transferability.  Except as provided in this Section 7, Shares of Restricted Stock
may not be sold, transferred, pledged, assigned, or otherwise alienated or hypothecated until the
end of the applicable Period of Restriction.



(d) Other Restrictions.  The Administrator, in its sole discretion, may impose such
other restrictions on Shares of Restricted Stock as it may deem advisable or appropriate.



(e) Removal of Restrictions.  Except as otherwise provided in this Section 7, Shares
of Restricted Stock covered by each Restricted Stock grant made under the Plan will be released
from escrow as soon as practicable after the last day of the Period of Restriction. The
Administrator, in its discretion, may accelerate the time at which any restrictions will lapse or
be removed.



(f) Voting Rights.  During the Period of Restriction, Service Providers holding Shares
of Restricted Stock granted hereunder may exercise full voting rights with respect to those Shares,
unless the Administrator determines otherwise.



(g) Dividends and Other Distributions.  During the Period of Restriction, Service
Providers holding Shares of Restricted Stock will be entitled to receive all dividends and other
distributions paid with respect to such Shares unless otherwise provided in the Award Agreement. If
any such dividends or distributions are paid in Shares, the Shares will be subject to the same
restrictions on transferability and forfeitability as the Shares of Restricted Stock with respect
to which they were paid.



(h) Return of Restricted Stock to Company.  On the date set forth in the Award
Agreement, the Restricted Stock for which restrictions have not lapsed will revert to the Company
and again will become available for grant under the Plan.



(i) Section 162(m) Performance Restrictions.  For purposes of qualifying grants of
Restricted Stock as “performance-based compensation” under Section 162(m) of the Code, the
Administrator, in its discretion, may set restrictions based upon the achievement of Performance
Goals. The Performance Goals will be set by the Administrator on or before the Determination Date.
In granting Restricted Stock which is intended to qualify under Section 162(m) of the Code, the
Administrator will follow any procedures determined by it from time to time to be necessary or
appropriate to ensure qualification of the Award under Section 162(m) of the Code (e.g., in
determining the Performance Goals).



8. Stock Appreciation Rights.



(a) Grant of SARs.  Subject to the terms and conditions of the Plan, a SAR may be
granted to Service Providers at any time and from time to time as will be determined by the
Administrator, in its sole discretion. The Administrator may grant Affiliated SARs, Freestanding
SARs, Tandem SARs, or any combination thereof.



(b) Number of Shares.  The Administrator will have complete discretion to determine
the number of SARs granted to any Service Provider; provided, however, no Service Provider will be
granted, in any Fiscal Year, SARs covering more than 1,500,000 Shares. Notwithstanding the
limitation in the previous sentence, in connection with his or her initial service a Service
Provider may be granted SARs covering up to an additional 1,500,000 Shares. The foregoing
limitations will be adjusted proportionately in connection with any change in the Company’s
capitalization as described in Section 13. In addition, if a SAR is cancelled in the same Fiscal
Year in which it was granted (other than in connection with a transaction described in Section 13),
the cancelled SAR will be counted against the numerical share limits set forth above.



(c) Exercise Price and Other Terms.  The Administrator, subject to the provisions of
the Plan, will have complete discretion to determine the terms and conditions of SARs granted under
the Plan; provided, however, that the per Share exercise price of a SAR will be no less than 100%
of the Fair Market Value per Share on the date of grant. However, the exercise price of Tandem or
Affiliated SARs will equal the exercise price of the related Option.



(d) Exercise of Tandem SARs.  Tandem SARs may be exercised for all or part of the
Shares subject to the related Option upon the surrender of the right to exercise the equivalent
portion of the related Option. A Tandem SAR may be exercised only with respect to the Shares for
which its related Option is then exercisable. With respect to a Tandem SAR granted in connection
with an Incentive Stock Option: (a) the Tandem SAR will expire no later than the expiration of the
underlying Incentive Stock Option; (b) the value of the payout with respect to the Tandem SAR will
be for no more than one hundred percent (100%) of the difference between the exercise price of the
underlying Incentive Stock Option and the Fair Market Value of the Shares subject to the underlying
Incentive Stock Option at the time the Tandem SAR is exercised; and (c) the Tandem SAR will be
exercisable only when the Fair Market Value of the Shares subject to the Incentive Stock Option
exceeds the Exercise Price of the Incentive Stock Option.



(e) Exercise of Affiliated SARs.  An Affiliated SAR will be deemed to be exercised
upon the exercise of the related Option. The deemed exercise of an Affiliated SAR will not
necessitate a reduction in the number of Shares subject to the related Option.



(f) Exercise of Freestanding SARs.  Freestanding SARs will be exercisable on such
terms and conditions as the Administrator, in its sole discretion, will determine.



(g) SAR Agreement.  Each SAR grant will be evidenced by an Award Agreement that will
specify the exercise price, the term of the SAR, the conditions of exercise, and such other terms
and conditions as the Administrator, in its sole discretion, will determine.



(h) Maximum Term/Expiration of SARs.  An SAR granted under the Plan will expire upon
the date determined by the Administrator, in its sole discretion, and set forth in the Award
Agreement. Notwithstanding the foregoing, the rules of Section 6(b) relating to the maximum term
and Section 6(d) relating to exercise also will apply to SARs.



(i) Payment of SAR Amount.  Upon exercise of an SAR, a Participant will be entitled to
receive payment from the Company in an amount determined by multiplying:




(i) The difference between the Fair Market Value of a Share on the date of exercise over the
exercise price; times




(ii) The number of Shares with respect to which the SAR is exercised.



At the discretion of the Administrator, the payment upon SAR exercise may be in cash, in
Shares of equivalent value, or in some combination thereof.



9. Performance Units and Performance Shares.



(a) Grant of Performance Units/Shares.  Performance Units and Performance Shares may
be granted to Service Providers at any time and from time to time, as will be determined by the
Administrator, in its sole discretion. The Administrator will have complete discretion in
determining the number of Performance Units and Performance Shares granted to each Participant
provided that during any Fiscal Year, for Performance Units or Performance Shares intended to
qualify as “performance-based compensation” within the meaning of Section 162(m) of the Code,
(i) no Participant will receive Performance Units having an initial value greater than $4,000,000,
and (ii) no Participant will receive more than 1,000,000 Performance Shares. Notwithstanding the
foregoing limitation, for Performance Shares intended to qualify as “performance-based
compensation” within the meaning of Section 162(m) of the Code, in connection with his or her
initial service, a Service Provider may be granted up to an additional 1,000,000 Performance
Shares.



(b) Value of Performance Units/Shares.  Each Performance Unit will have an initial
value that is established by the Administrator on or before the date of grant. Each Performance
Share will have an initial value equal to the Fair Market Value of a Share on the date of grant.



(c) Performance Objectives and Other Terms.  The Administrator will set performance
objectives or other vesting provisions in its discretion which, depending on the extent to which
they are met, will determine the number or value of Performance Units/Shares that will be paid out
to the Service Providers. Each Award of Performance Units/Shares will be evidenced by an Award
Agreement that will specify the Performance Period, and such other terms and conditions as the
Administrator, in its sole discretion, will determine. The Administrator may set performance
objectives based upon the achievement of Company-wide, divisional, or individual goals, applicable
federal or state securities laws, or any other basis determined by the Administrator in its
discretion.



(d) Earning of Performance Units/Shares.  After the applicable Performance Period has
ended, the holder of Performance Units/Shares will be entitled to receive a payout of the number of
Performance Units/Shares earned by the Participant over the Performance Period, to be determined as
a function of the extent to which the corresponding performance objectives or other vesting
provisions have been achieved. After the grant of a Performance Unit/Share, the Administrator, in
its sole discretion, may reduce or waive any performance objectives or other vesting provisions for
such Performance Unit/Share.



(e) Form and Timing of Payment of Performance Units/Shares.  Payment of earned
Performance Units/Shares will be made as soon as practicable after the expiration of the applicable
Performance Period. The Administrator, in its sole discretion, may pay earned Performance
Units/Shares in the form of cash, in Shares (which have an aggregate Fair Market Value equal to the
value of the earned Performance Units/Shares at the close of the applicable Performance Period) or
in a combination thereof.



(f) Cancellation of Performance Units/Shares.  On the date set forth in the Award
Agreement, all unearned or unvested Performance Units/Shares will be forfeited to the Company, and
again will be available for grant under the Plan.



(g) Section 162(m) Performance Restrictions.  For purposes of qualifying grants of
Performance Units/Shares as “performance-based compensation” under Section 162(m) of the Code, the
Administrator, in its discretion, may set restrictions based upon the achievement of Performance
Goals. The Performance Goals will be set by the Administrator on or before the Determination Date.
In granting Performance Units/Shares which are intended to qualify under Section 162(m) of the
Code, the Administrator will follow any procedures determined by it from time to time to be
necessary or appropriate to ensure qualification of the Award under Section 162(m) of the Code
(e.g., in determining the Performance Goals).



10. Performance Goals.  The granting and/or vesting of Awards of Restricted Stock,
Performance Shares and Performance Units and other incentives under the Plan may be made subject to
the attainment of performance goals relating to one or more business criteria within the meaning of
Section 162(m) of the Code and may provide for a targeted level or levels of achievement
(“Performance Goals” ) including: (i) Cash Position, (ii) Clinical Progression, (iii) Collaboration
Arrangement, (iv) Collaboration Progression, (v) Earnings Per Share, (vi) Financing Event,
(vii) Net Income, (viii) Operating Cash Flow, (ix) Operating Expenses, (x) Operating Income,
(xi) Product Approval, (xii) Product Revenues, (xiii) Profit After Tax, (xiv) Projects in
Development, (xv) Regulatory Filings, (xvi) Return on Assets, (xvii) Return on Equity,
(xviii) Revenue Growth, and (xix) Total Stockholder Return. Prior to the Determination Date, the
Administrator will determine whether any significant element(s) will be included in or excluded
from the calculation of any Performance Goal with respect to any Participant. Any Performance Goals
may be used to measure the performance of the Company as a whole or a business unit of the Company
and may be measured relative to a peer group or index. With respect to any Award, Performance Goals
may be used alone or in combination. The Performance Goals may differ from Participant to
Participant and from Award to Award. Prior to the Determination Date, the Administrator will
determine whether any significant element(s) will be included in or excluded from the calculation
of any Performance Goal with respect to any Participant. In all other respects, Performance Goals
will be calculated in accordance with the Company’s financial statements, generally accepted
accounting principles, or under a methodology established by the Administrator prior to the
issuance of an Award, which is consistently applied and identified in the financial statements,
including footnotes, or the management discussion and analysis section of the Company’s annual
report. In determining the amounts earned by a Participant pursuant to an Award intended to
qualified as “performance-based compensation” under Section 162(m) of the Code, the Administrator
will have the right to reduce or eliminate (but not to increase) the amount payable at a given
level of performance to take into account additional factors that the Administrator may deem
relevant to the assessment of individual or corporate performance for the Performance Period. A
Participant will be eligible to receive payment pursuant to an Award intended to qualify as
“performance-based compensation” under Section 162(m) of the Code for a Performance Period only if
the Performance Goals for such period are achieved.



11. Leaves of Absence.  Unless the Administrator provides otherwise, vesting of Awards
granted hereunder will be suspended during any unpaid leave of absence. A Service Provider will not
cease to be an Employee in the case of (i) any leave of absence approved by the Company or (ii)
transfers between locations of the Company or between the Company, its Parent, or any Subsidiary.
For purposes of Incentive Stock Options, no such leave may exceed ninety (90) days, unless
reemployment upon expiration of such leave is guaranteed by statute or contract. If reemployment
upon expiration of a leave of absence approved by the Company is not so guaranteed, then six months
and a day following the 1st day of such leave any Incentive Stock Option held by the Participant
will cease to be treated as an Incentive Stock Option and will be treated for tax purposes as a
Nonstatutory Stock Option.



12. Transferability of Awards.  Unless determined otherwise by the Administrator, an
Award may not be sold, pledged, assigned, hypothecated, transferred, or disposed of in any manner
other than by will or by the laws of descent or distribution and may be exercised, during the
lifetime of the Participant, only by the Participant. If the Administrator makes an Award
transferable, such Award will contain such additional terms and conditions as the Administrator
deems appropriate; provided, however, that the Administrator may only make an Award transferable to
one or more of the following: (i) the Participant’s spouse, children or grandchildren (including
any adopted and step children or grandchildren), parents, grandparents, siblings or any “Family
Member” (as defined pursuant to Rule 701 of the Securities Act of 1933, as amended) of the
Participant; (ii) a trust for the benefit of one or more of the Participant or the persons referred
to in clause (i); (iii) a partnership, limited liability company or corporation in which the
Participant or the persons referred to in clause (i) are the only partners, members or
stockholders; or (iv) charitable donations.



13. Adjustments; Dissolution or Liquidation; Merger or Change in Control.



(a) Adjustments.  In the event that any dividend or other distribution (whether in the
form of cash, Shares, other securities, or other property), recapitalization, stock split, reverse
stock split, reorganization, merger, consolidation, split-up, spin-off, combination, repurchase, or
exchange of Shares or other securities of the Company, or other change in the corporate structure
of the Company affecting the Shares occurs, the Administrator, in order to prevent diminution or
enlargement of the benefits or potential benefits intended to be made available under the Plan,
shall appropriately adjust the number and class of Shares that may be delivered under the Plan
and/or the number, class, and price of Shares covered by each outstanding Award, the numerical
Share limits in Sections 3, 6, 7, 8, and 9 of the Plan.



(b) Dissolution or Liquidation.  In the event of the proposed dissolution or
liquidation of the Company, the Administrator will notify each Participant as soon as practicable
prior to the effective date of such proposed transaction. To the extent it has not been previously
exercised, an Award will terminate immediately prior to the consummation of such proposed action.



(c) Change in Control.  In the event of a Change in Control, each outstanding Award
will be assumed or an equivalent option or right substituted by the successor corporation or a
Parent or Subsidiary of the successor corporation. In the event that the successor corporation
refuses to assume or substitute for the Award, the Participant will fully vest in and have the
right to exercise all of his or her outstanding Options and Stock Appreciation Rights, including
Shares as to which such Awards would not otherwise be vested or exercisable, all restrictions on
Restricted Stock shall lapse, and, with respect to Performance Shares and Performance Units, all
performance goals or other vesting criteria will be deemed achieved at target levels and all other
terms and conditions met. In addition, if an Option or Stock Appreciation Right is not assumed or
substituted for in the event of a Change in Control, the Administrator will notify the Participant
in writing or electronically that the Option or Stock Appreciation Right will be fully vested and
exercisable for a period of time determined by the Administrator in its sole discretion, and the
Option or Stock Appreciation Right will terminate upon the expiration of such period.



With respect to Awards granted to an Outside Director that are assumed or substituted for, if
on the date of or following such assumption or substitution the Participant’s status as a Director
or a director of the successor corporation, as applicable, is terminated other than upon a
voluntary resignation by the Participant not at the request of the successor, then the Participant
will fully vest in and have the right to exercise Options and/or Stock Appreciation Rights as to
all of the Shares subject to the Award, including Shares as to which such Awards would not
otherwise be vested or exercisable, all restrictions on Restricted Stock shall lapse, and, with
respect to Performance Shares and Performance Units, all performance goals or other vesting
criteria will be deemed achieved at target levels and all other terms and conditions met.



For the purposes of this subsection (c), an Award will be considered assumed if, following the
Change in Control, the Award confers the right to purchase or receive, for each Share subject to
the Award immediately prior to the Change in Control, the consideration (whether stock, cash, or
other securities or property) or, in the case of a Stock Appreciation Right upon the exercise of
which the Administrator determines to pay cash or a Performance Share or Performance Unit which the
Administrator can determine to pay in cash, the fair market value of the consideration received in
the merger or Change in Control by holders of Common Stock for each Share held on the effective
date of the transaction (and if holders were offered a choice of consideration, the type of
consideration chosen by the holders of a majority of the outstanding Shares); provided, however,
that if such consideration received in the Change in Control is not solely common stock of the
successor corporation or its Parent, the Administrator may, with the consent of the successor
corporation, provide for the consideration to be received upon the exercise of an Option or Stock
Appreciation Right or upon the payout of a Performance Share or Performance Unit, for each Share
subject to such Award (or in the case of Performance Units, the number of implied shares determined
by dividing the value of the Performance Units by the per share consideration received by holders
of Common Stock in the Change in Control), to be solely common stock of the successor corporation
or its Parent equal in fair market value to the per share consideration received by holders of
Common Stock in the Change in Control.



Notwithstanding anything in this Section 13(c) to the contrary, an Award that vests, is earned
or paid-out upon the satisfaction of one or more performance goals will not be considered assumed
if the Company or its successor modifies any of such performance goals without the Participant’s
consent; provided, however, a modification to such performance goals only to reflect the successor
corporation’s post-Change in Control corporate structure will not be deemed to invalidate an
otherwise valid Award assumption.



14. Tax Withholding



(a) Withholding Requirements.  Prior to the delivery of any Shares or cash pursuant to
an Award (or exercise thereof), the Company will have the power and the right to deduct or
withhold, or require a Participant to remit to the Company, an amount sufficient to satisfy
federal, state, local, foreign or other taxes (including the Participant’s FICA obligation)
required to be withheld with respect to such Award (or exercise thereof).



(b) Withholding Arrangements.  The Administrator, in its sole discretion and pursuant
to such procedures as it may specify from time to time, may permit a Participant to satisfy such
tax withholding obligation, in whole or in part by (without limitation) (i) paying cash,
(ii) electing to have the Company withhold otherwise deliverable cash or Shares having a Fair
Market Value equal to the amount required to be withheld, (iii) delivering to the Company
already-owned Shares having a Fair Market Value equal to the amount required to be withheld, or
(iv) selling a sufficient number of Shares otherwise deliverable to the Participant through such
means as the Administrator may determine in its sole discretion (whether through a broker or
otherwise) equal to the amount required to be withheld. The amount of the withholding requirement
will be deemed to include any amount which the Administrator agrees may be withheld at the time the
election is made, not to exceed the amount determined by using the maximum federal, state or local
marginal income tax rates applicable to the Participant with respect to the Award on the date that
the amount of tax to be withheld is to be determined. The Fair Market Value of the Shares to be
withheld or delivered will be determined as of the date that the taxes are required to be withheld.



15. No Effect on Employment or Service.  Neither the Plan nor any Award will confer
upon a Participant any right with respect to continuing the Participant’s relationship as a Service
Provider with the Company, nor will they interfere in any way with the Participant’s right or the
Company’s right to terminate such relationship at any time, with or without cause, to the extent
permitted by Applicable Laws.



16. Date of Grant.  The date of grant of an Award will be, for all purposes, the date
on which the Administrator makes the determination granting such Award, or such later date as is
determined by the Administrator. Notice of the determination will be provided to each Participant
within a reasonable time after the date of such grant.



17. Term of Plan.  Subject to Section 21 of the Plan, the Plan will become effective
upon its adoption by the Board. It will continue in effect for a term of ten (10) years unless
terminated earlier under Section 18 of the Plan.



18. Amendment and Termination of the Plan.



(a) Amendment and Termination.  The Administrator may at any time amend, alter,
suspend or terminate the Plan.



(b) Stockholder Approval.  The Company will obtain stockholder approval of any Plan
amendment to the extent necessary and desirable to comply with Applicable Laws.



(c) Effect of Amendment or Termination.  No amendment, alteration, suspension or
termination of the Plan will impair the rights of any Participant, unless mutually agreed otherwise
between the Participant and the Administrator, which agreement must be in writing and signed by the
Participant and the Company. Termination of the Plan will not affect the Administrator’s ability to
exercise the powers granted to it hereunder with respect to Awards granted under the Plan prior to
the date of such termination.



19. Conditions Upon Issuance of Shares.



(a) Legal Compliance.  Shares will not be issued pursuant to the exercise of an Award
unless the exercise of such Award and the issuance and delivery of such Shares will comply with
Applicable Laws and will be further subject to the approval of counsel for the Company with respect
to such compliance.



(b) Investment Representations.  As a condition to the exercise of an Award, the
Company may require the person exercising such Award to represent and warrant at the time of any
such exercise that the Shares are being purchased only for investment and without any present
intention to sell or distribute such Shares if, in the opinion of counsel for the Company, such a
representation is required.



20. Inability to Obtain Authority.  The inability of the Company to obtain authority
from any regulatory body having jurisdiction, which authority is deemed by the Company’s counsel to
be necessary to the lawful issuance and sale of any Shares hereunder, will relieve the Company of
any liability in respect of the failure to issue or sell such Shares as to which such requisite
authority will not have been obtained.



21. Stockholder Approval.  The Plan will be subject to approval by the stockholders of
the Company within twelve (12) months after the date the Plan is adopted. Such stockholder approval
will be obtained in the manner and to the degree required under Applicable Laws.