SAT Report

PMN Number: P-12-0150

SAT Date: 1/27/2012

Print Date: 12/3/2013

Related cases:

Health related cases: 

Ecotox related cases: 

Concern levels:

Type of Concern: Health Eco Comments

Level of Concern: 1 3

 Persistence Bioaccum Toxicity Comments

1 11

Exposure Based Review:

Health: No

Ecotox: Yes

Routes of exposure: Health: No exposures needed

Ecotox: All releases to water

Fate: ;

P2Rec Comments:

Comment: Forward

Keywords:

 Keywords: AQUATOX-A,C

Summary of Assessment:

 Fate:

Fate Summary: P-12-0150
log Fish BCF = 1.60 (E)

log Fish BAF = 1.11 (E) 

POTW removal (%) = 90 via biodeg; OECD 301B (Mod Sturm CO2 ev): 91%/28d.

Time for complete ultimate aerobic biodeg = wk

Sorption to soils/sediments = low

PBT Potential: P1B1

*CEB FATE: Migration to ground water = slow due to biodeg

 Health:

 Health Summary: Absorption is poor all routes based on analogs. Expect 

poor hydrolysis of the esters. No significant health concerns. Low concern. 

 Test Data: TOXICITY DATA for close analog 

negative in Salmonella with and without activation

negative in oral rat micronucleus assay

negative in mouse lymphoma cells with and without activation

14-day oral study in rats - no deaths or signs of toxicity at doses up to 2.3 g/kg

slight eye irritant in rabbits

slight dermal irritant in rabbits

acute intravenous study in mice - no deaths at doses up to 2.3 g/kg; recumbent position, 

piloerection, absence of spontaneous locomotor activity, decrease in muscle tone

acute oral study in mice - no deaths or signs of toxicity at doses up to 2.3 g/kg

acute intravenous study in rats - deaths a t 2.3 and 1.15 g/kg, no deaths at 0.575 g/kg; reduced 

spontaneous locomotor activity, absence of reactivity, decrease in body, abdominal, and limb 

tone at 0.575 g/kg

acute oral study in rats - no deaths or signs of toxicity at doses up to 2.3 g/kg

negative for dermal sensitization in the mouse local lymph node assay at 100% concentration

oral developmental toxicity study in rats - no adverse effects at doses up to 2.3 g/kg ( 2 fetuses 

from the same litter had omphalocele/protrusion of part of the intestine at the umbilicus)

90-day oral study in rats - reduced body weight gain in males at 1.15 and 2.3 g/kg; decrease in 

mobile spermatozoa ans total number of spermatozoa at 2.3 g/kg

28-day oral study in rats - NOAEL = 2.3 g/kg

oral developmental toxicity study in rats - marginal reduction in ossification and reduced fetal 

weights ay 2.3 g/kg

oral absorption and excretion study in rats - half-life = 1.9 to 3.4 hours

 Ecotox:

Test Organism Test 

Type

Test End 

Point

Predicted Measured Comments

fish 96-h LC50 *

daphnid 48-h LC50 * > 100 (invalid)

green algal 96-h EC50 0.099

fish _ chronic value 0.010
daphnid _ chronic 

value

0.097

algal _ chronic 

value

0.089

Sewage Sludge 3-h EC50 _

Sewage Sludge _ Chronic 

Value

_

Ecotox Values Comments: Predictions are based on SARs for esters; SAR chemical class = 

ester; MW 399; 

 pH7; effective concentrations based on 100% active ingredients and mean measured 

concentrations; hardness <150.0 mg/L as CaCO3; and TOC <2.0 mg/L;

Factors Values Comments

Assessment Factor 10

Concentration of Concern 

(ppb)

1

SARs esters

SAR Class ester

Ecotox Category Esters

Ecotox Factors Comments: 

 SAT Chair: L Keifer 564-8916