Exhibit 31.1:  Certification of Chief Executive Officer pursuant to Section
               302(a) of the Sarbanes-Oxley Act

                   CERTIFICATION OF THE CHIEF EXECUTIVE OFFICER
               PURSUANT TO SECTION 302(a) OF THE SARBANES OAXLEY-ACT


I, Chris M. Hymel, certify that:

1. I have reviewed the annual report (on Form 10-K) for the year ended December
   31, 2014 as well as Amendment Nos. 1, 2, 3 and 4 (on Form 10-K/A) of Signal
   Advance, Inc.;

2. Based on my knowledge, this report does not contain any untrue statement of a
   material fact or omit to state a material fact necessary to make the state-
   ments made, in light of the circumstances under which such statements were
   made, not misleading with respect to the period covered by this report;

3. Based on my knowledge, the financial statements, and other financial
   information included in this report, fairly present in all material respects
   the financial condition, results of operations and cash flows of the
   registrant as of, and for, the periods presented in this report;

4. I am responsible for establishing and maintaining disclosure controls and
   procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and
   internal control over financial reporting (as defined in Exchange Act Rules
   13a-15(f) and 15d-15(f)) for the registrant and have:

   a. Designed such disclosure controls and procedures, or caused such
      disclosure controls and procedures, to be designed under my supervision,
      to ensure that material information relating to the registrant, including
      any consolidated subsidiaries, is made known to me by others within those
      entities, particularly during the period in which this report is being
      prepared;

   b. Designed such internal control over financial reporting, or caused such
      internal control over financial reporting to be designed under my
      supervision, to provide reasonable assurance regarding the reliability of
      financial reporting and the preparation of financial statements for
      external purposes in accordance with generally accepted accounting
      principles;

   c. Evaluated the effectiveness of the registrant's disclosure controls and
      procedures and presented in this report my conclusions about the
      effectiveness of the disclosure controls and procedures, as of the end of
      the period covered by this report based on such evaluation; and

   d. Disclosed in this report any change in the registrant's internal control
      over financial reporting that occurred during the registrant's most recent
      fiscal quarter (the registrant's fourth fiscal quarter in the case of an
      annual report) that has materially affected, or is reasonably likely to
      materially affect, the registrant's internal control over financial
      reporting; and




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5. I have disclosed, based on my most recent evaluation of internal control over
   financial reporting, to the registrant's auditors and the audit committee of
   the registrant's board of directors (or persons performing the equivalent
   functions):

   a. All significant deficiencies and material weaknesses in the design or
      operation of internal control over financial reporting which are
      reasonably likely to adversely affect the registrant's ability to record,
      process, summarize and report financial information; and

   b. Any fraud, whether or not material, that involves management or other
      employees who have a significant role in the registrant's internal control
      over financial reporting.


     /s/Chris M. Hymel

     Chris M. Hymel
     President/Treasurer


November 24, 2015




































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