UNITED STATES
                        SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C.  20549

                                   FORM 10-K/A

                                 Amendment No. 4


[X] ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE
    ACT OF 1934
                   For the fiscal year ended December 31, 2014

[ ] TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES
    EXCHANGE ACT OF 1934

           For the transition period from ___________ to ___________

                       Commission File No. 000-54626


                             SIGNAL ADVANCE, INC.
             (Exact name of registrant as specified in its charter)



                                    Texas
         (State or Other Jurisdiction of Incorporation or Organization)

                                     8731
             (Primary Standard Industrial Classification Number)

                                  76-0373052
                     (IRS Employer Identification Number)

                             2520 County Road 81
                            Rosharon, Texas 77583
                               (713) 510-7445
          (Address and telephone number of principal executive offices)


Securities registered pursuant to Section 12(b) of the Act:  None

Securities registered pursuant to Section 12(g) of the Act:  None













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Indicate by check mark whether the registrant is a well-known seasoned
issuer, as defined in Rule 405 of the Securities Act.  Yes [ ] No [X]

Indicate by check mark if the registrant is not required to file reports
pursuant to Section 13 or Section 15(d) of the Act.  Yes [ ] No [X]

Indicate by check mark whether the registrant (1) has filed all reports
required to be filed by Section 13 or 15(d) of the Securities Exchange Act
of 1934 during the preceding 12 months (or for shorter period that the
registrant as required to file such reports), and (2) has been subject to
such filing requirements for the past 90 days.  Yes [X] No [ ]

Indicate by check mark if disclosure of delinquent filers pursuant to Item
405 of Regulation S-K is not contained herein, and will not be contained, to
the best of registrant's knowledge, in definitive proxy or information
statements incorporated by reference in Part III of this Form 10-K or any
amendment to this Form 10-K.  Yes [ ] No [X]

Indicate by check mark whether the registrant is a large accelerated filer,
an accelerated filer, or a non-accelerated filer. See definition of
"accelerated filer and large accelerated filer" in Rule 12b-2 of the Exchange
Act.(Check one)

      Large accelerated filer  [ ]          Accelerated filer          [ ]
      Non-accelerated filer    [ ]          Smaller reporting company  [X]

Indicate by check mark whether the registrant is a shell company (as defined
in Rule 12b-2 of the Act).  Yes [ ] No [X]

As of November 24, 2014, the registrant had 10,460,077 shares of common stock
issued and outstanding, no par value.



                               EXPLANATORY NOTE

Signal Advance, Inc. (the "Company") is filing this Amendment No. 4 (on Form
10-K/A) to its Annual Report on Form 10-K for the fiscal year ended December
31, 2014 (the "Original Filing"), as originally filed with the Securities and
Exchange Commission on March 31, 2015 and amendments (Amendment Nos. 1, 2 and
3) filed on April 4, 2015 and November 10, 2015. This Amendment No. 4 is being
filed solely to include the correct the date on the Certification of Chief
Executive Officer and Chief Financial Officer under Section 1350 as Adopted
Pursuant to Section 906 of the Sarbanes-Oxley Act (Exhibit 32.1) and to provide
updated certifications from the Chief Executive Officer and Chief Financial
Officer pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 (Exhibits
31.1 and 31.2).

Except as described above, this Amendment No. 1 does not otherwise amend or
update any exhibit or disclosure set forth in the Original Filing or the
subsequent Amendment Nos. 1, 2 or 3.






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TABLE OF CONTENTS


                                    PART II

   ITEM 9A(T) Controls and Procedures...................................4


                                    PART IV

   ITEM 15    Exhibits..................................................6












































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                                     PART II

Item 9A(T). Controls and Procedures

MANAGEMENT'S REPORT ON DISCLOSURE CONTROLS AND PROCEDURES:  Management is
responsible for establishing and maintaining adequate internal control over
financial reporting (as defined in Exchange Act Rule 13a-15(f)). Internal
control over financial reporting is a process designed to provide reasonable
assurance regarding the reliability of financial reporting and the preparation
of financial statements for external purposes in accordance with accounting
principles generally accepted in the United States of America. Because of its
inherent limitations, internal control over financial reporting may not prevent
or detect misstatements. Also, projections of any evaluation of effectiveness
to future periods are subject to the risk that controls may become inadequate
because of changes in conditions, or that compliance with the policies or
procedures may deteriorate. Management evaluated the effectiveness of the
Company's internal control over financial reporting as of December 31, 2014
using the criteria established in 'Internal Control - Integrated Framework'
(1992) issued by the Committee of Sponsoring Organizations of the Treadway
Commission ("COSO"). Management concluded that the Company's disclosure controls
and procedures over financial reporting were not effective as of December 31,
2014 based on material weakenesses listed below.

A material weakness is a deficiency, or combination of deficiencies, in
internal control over financial reporting, such that there is a reasonable
possibility that a material misstatement of the Company's annual or interim
financial statements will not be prevented or detected on a timely basis.

MANAGEMENT'S REPORT ON INTERNAL CONTROL OF FINANCIAL REPORTING.  Management is
also responsible for establishing and maintaining adequate internal control over
financial reporting. In its assessment of the effectiveness of internal control
over financial reporting as of December 31, 2014, based on the above referenced
guidelines, the Company determined that there were control deficiencies that
constituted material weaknesses, as listed below.

1) We do not have an Audit Committee - While not being legally obligated to
   have one, management believes that such a committee, including a financial
   expert member, is an important entity level control over the Company's
   financial statement. Currently, the Board of Directors acts as the Audit
   Committee, and does not include an independent member to provide the
   necessary oversight over management's activities.

2) We did not maintain appropriate cash controls - Due to accounting resource
   limitations, as of December 31, 2014, the Company has not maintained
   sufficient internal controls over financial reporting for the cash process
   based on the failure to segregate cash handling and accounting functions,
   and the lack of the requirement for dual signatures on the Company's bank
   accounts. Alternatively, the effects of poor cash controls were mitigated by
   the fact that the Company had limited transactions in their bank accounts.

3) We did not implement appropriate information technology controls - As at
   December 31, 2014, the Company retains copies of all financial data and
   material agreements and periodically make backups of the Company's data;
   however there is no formal procedure or evidence of normal backup of the
   Company's data or off-site storage of data in the event of theft,
   misplacement, or loss due to unmitigated factors.

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As such, the Company concluded that these control deficiencies resulted in a
reasonable possibility that a material misstatement of the annual or interim
financial statements will not be prevented or detected on a timely basis by the
company's internal controls.  As a result of the material weaknesses described
above, management has concluded that the Company did not maintain effective
internal control over financial reporting as of December 31, 2014 based on
criteria established in Internal Control - Integrated Framework (1992) issued
by COSO.

CHANGES IN INTERNAL CONTROL OVER FINANCIAL REPORTING:  There has been no
change in our internal control over financial reporting identified in connection
with our evaluation we conducted of the effectiveness of our internal control
over financial reporting as of December 31, 2014, that occurred subsequent to
the evaluation that has materially affected, or is reasonably likely to
materially affect, our internal control over financial reporting.

This annual report does not include an attestation report of the Company's
registered public accounting firm regarding internal control over financial
reporting. Management's report was not subject to attestation by the Company's
registered public accounting firm pursuant to rules of the SEC applicable to an
Emerging Growth Company  that permit the Company to provide only management's
report in this annual report.

































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                                  PART IV

Item 15. Exhibits


Exhibit 31.1:  Certification of Chief Executive Officer pursuant to Section
               302(a) of the Sarbanes-Oxley Act

Exhibit 31.2:  Certification of Chief Financial Officer pursuant to Section
               302(a) of the Sarbanes-Oxley Act

Exhibit 32.1:  Certification of Chief Executive Officer and Chief Financial
               Officer under Section 1350 as Adopted Pursuant to Section 906
               of the Sarbanes-Oxley Act











































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SIGNATURES

In accordance with the requirements of the Exchange Act, the registrant
caused this report to be signed on its behalf by the undersigned, thereunto
duly authorized.



Dated: November 24, 2015
SIGNAL ADVANCE, INC.


                                       By: /s/ Chris M. Hymel




                                        Chris M. Hymel, President/Treasurer

Pursuant to the requirements of the Securities Act of 1933, this Registration
Statement has been signed by the following persons in the capacities and as
of the dates indicated.

SIGNATURE                 TITLE                              DATE
-----------------------   -------------------------------    -----------------

/s/ Chris M. Hymel        Member, Board of Directors,        November 24, 2015
Chris M. Hymel            President and Treasurer
                          (Principal Executive, Financial
                           and Accounting Officer)


/s/ Malcolm H. Skolnick   Member: Board of Directors,        November 24, 2015
Malcolm H. Skolnick       Secretary


/s/ Richard C. Seltzer    Member: Board of Directors         November 24, 2015
Richard C. Seltzer



























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