### This List of Cosm Endpoints is the same list provided in appendix D of the w **hite paper. The data as scored w ould lead to a CE-LOC of 4ppb for the 60-day**  **assessment period as described in the presentations.**

**Initial Test**  **Conc (μg/L)**  **Duration (d)*** **Effect (Y/N)? Reference(s)** 

0.5 7 N Brockway et al. 1984 0.5 29 N Brockway et al. 1984 1 20 N Gustavson and W ängberg 1995 5 7 N Brockway et al. 1984 2 28 N Jurgensen and Hoagland 1990 3.2 21 N Pratt et al. 1988 5 14 N Gruessner and W atzin 1996 5 35 N van den Brink et al. 1995 10 20 N Gustavson and W ängberg 1995 10 21 N Pratt et al. 1988 10 30 N Johnson 1986 5 70 N Brockway et al. 1984 20 20 N Gustavson and W ängberg 1995 25 30 N Ly nch et al. 1985 20 42 N Stay et al. 1989 30 28 N Jurgensen and Hoagland 1990 100 28 N Jurgensen and Hoagland 1990 100 30 N Johnson 1986 6.4 36 N Rely ea, 2009 30 40 N Seguin et al. 2001a 2 40 N Seguin et al. 2001a



### Original Data

207 25 N Boone and James (2003) 20 51 N Diana et al. (2000) 25 42 N McGregor et al. (2008) 50 42 N McGregor et al. (2008) 2 40 Y Seguin et al. 2001b 1078 0.083333333 Y Guasch and Sabater (1998)

10 10 Y Berard et al. 1999a 1 , Berard et al. 1999b, Berard and Benninghoff 2001, Sequin et al. 2001b, Leboulanger et al. 2001 24.3 7 Y Downing et al. 2004
10 21 Y Kosinski 1984; Kosinski and Merkle 1984 15 15 Y Detenback et al 1996 24 12 Y Krieger et al. 1988 50 12 Y Brockway et al. 1984 32 21 Y Pratt et al. 1988 100 7 Y Brockway et al. 1984 100 7 Y Moorhead and Kosinski 1986 25 30 Y Rohr and Crumrine, 2005 30 25 Y Seguin et al. 2002 148 7 Y Downing et al. 200425 43 Y Detenback et al 1996 30 40 Y Seguin et al. 2001b
20 63 Y deNoy elles et al. 1982; deNoy elles et al. 1989 79 17 Y Detenback et al 1996 100 14 Y Hamala and Kollig 1985 100 15 Y Brockway et al. 1984 50 32 Y Detenback et al 1996 134 12 Y Krieger et al. 1988

20 365 Y Carney 1983; Kettle et al. 1987; deNoy elles et al. 1989; deNoy elles et al. 1994, deNoy elles & Kettle 1980, Dewey

1986

100 21 Y Kosinski 1984; Kosinski and Merkle 1984 110 21 Y Pratt et al. 1988 50 55 Y Brockway et al. 1984 53 53 Y Stay et al. 1985 117 28 Y Rohr et al., 2008 100 42 Y Stay et al. 1989 100 42 Y McGregor et al. (2008) 84 53 Y Stay et al. 1985 80 56 Y Hamilton et al 1987 500 12 Y Brockway et al. 1984 1000 7 Y Moorhead and Kosinski 1986 337 21 Y Pratt et al. 1988 140 56 Y Hamilton et al 1987 204 42 Y Stay et al. 1989
100 365 Y deNoy elles et al. 1989 Carney 100 365 Y deNoy elles et al. 1989 Carney 1983 100 96 Y Hamilton et al. 1988
100 96 Y Herman et al. 1986; Hamilton et al. 1989 100 360 Y deNoy elles et al. 1989 170 53 Y Stay et al. 1985 196 51 Y Diana et al. (2000) 250 42 Y McGregor et al. (2008)
84 173 Y Knauert et al., 2008; Knauert et al., 2009
200 340 Y deNoy elles et al. 1989 Carney 1983 200 360 Y deNoy elles et al. 1989
1000 21 Y Kosinski 1984; Kosinski and Merkle 1984 500 42 Y Stay et al. 1989 430 53 Y Stay et al. 1985 1000 30 Y Johnson 1986
500 63 Y deNoy elles et al. 1982; deNoy elles et al. 1989 1000 42 Y Stay et al. 1989 820 53 Y Stay et al. 1985500 365 Y Carney 1983; Kettle et al. 1987; deNoy elles et al. 1989; deNoy elles et al. 1994 5000 12 Y Brockway et al. 1984 10000 7 Y Moorhead and Kosinski 1986 2036 51 Y Diana et al. (2000)
10000 21 Y Kosinski 1984; Kosinski and Merkle 1984 5000 42 Y Stay et al. 1989 3980 53 Y Stay et al. 1985 1 18 Y Lam pert et al 1989 0.1 21 Y Lam pert et al 1989

### This List of Cosm Endpoints is the same list provided in appendix D of the w **hite paper. The data as scored w ould lead to a CE-LOC of 4ppb for the 60-day**  **assessment period as described in the presentations.**

**7-Day Test Concentration 14-Day Test Concentration**  **30-Day Test Concentration**

0.50 0.25 0.12 2.07 1.04 0.48 2.86 1.43 0.67 5.00 2.50 1.17 8.00 4.00 1.87 9.60 4.80 2.24 10.00 5.00 2.33 25.00 12.50 5.83 28.57 14.29 6.67 30.00 15.00 7.00 42.86 21.43 10.00 50.00 25.00 11.67 57.14 28.57 13.33 107.14 53.57 25.00 120.00 60.00 28.00 120.00 60.00 28.00 400.00 200.00 93.33 428.57 214.29 100.00 32.91 16.46 7.68 171.43 85.71 40.00 11.43 5.71 2.67



### Endpoints Normalized to A **ssessment Period**

739.29 369.64 172.50 145.71 72.86 34.00 150.00 75.00 35.00 300.00 150.00 70.00 11.43 5.71 2.67 12.83 6.42 2.99

14.29 7.14 3.33

24.30 12.15 5.67
30.00 15.00 7.00
32.14 16.07 7.50 41.14 20.57 9.60 85.71 42.86 20.00 96.00 48.00 22.40 100.00 50.00 23.33 100.00 50.00 23.33 107.14 53.57 25.00 107.14 53.57 25.00 148.00 74.00 34.53153.57 76.79 35.83 171.43 85.71 40.00
180.00 90.00 42.00
191.86 95.93 44.77 200.00 100.00 46.67 214.29 107.14 50.00 228.57 114.29 53.33 229.71 114.86 53.60

1042.86 521.43 243.33

300.00 150.00 70.00
330.00 165.00 77.00 392.86 196.43 91.67 401.29 200.64 93.63 468.00 234.00 109.20 600.00 300.00 140.00 600.00 300.00 140.00 636.00 318.00 148.40 640.00 320.00 149.33 857.14 428.57 200.00 1000.00 500.00 233.33 1011.00 505.50 235.90 1120.00 560.00 261.33 1224.00 612.00 285.60
5214.29 2607.14 1216.67
1371.43 685.71 320.00
1371.43 685.71 320.00
5142.86 2571.43 1200.00 1287.14 643.57 300.33 1428.00 714.00 333.20 1500.00 750.00 350.00
2076.00 1038.00 484.40

9714.29 4857.14 2266.67
10285.71 5142.86 2400.00
3000.00 1500.00 700.00
3000.00 1500.00 700.00 3255.71 1627.86 759.67 4285.71 2142.86 1000.00
4500.00 2250.00 1050.00
6000.00 3000.00 1400.00 6208.57 3104.29 1448.6726071.43 13035.71 6083.33

8571.43 4285.71 2000.00 10000.00 5000.00 2333.33 14833.71 7416.86 3461.20
30000.00 15000.00 7000.00
30000.00 15000.00 7000.00 30134.29 15067.14 7031.33 2.57 1.29 0.60 0.30 0.15 0.07

### This List of Cosm Endpoints is the same list provided in appendix D of the w **hite paper. The data as scored w ould lead to a CE-LOC of 4ppb for the 60-day** 

**assessment period as described in the presentations.**

**60-Day Test Concentration**

0.06 AVERAGE 13.99 430.29 50 0.24 0.33 **60-DA**

**Y No Effects**  **Effects** 0.58 0.93 Min 0.06 0.04 **CE-LOC** 1.12 Max 86.25 3515.67 **4** 1.17 5th percentile 0.26 1.51 5 **4** 2.92 10th percentile 0.43 3.55 10 **4** 3.33 20th percentile 1.08 12.00 20 **4** 3.50 50th percentile 5.00 74.20 50 **4** 5.00 95th percentile 49.33 2910.56 95 **4** 5.83 6.67 12.50 14.00 14.00 46.67 **30-DA**

**Y No Effects**  **Effects** 50.00 3.84 Min 0.12 0.07 **CE-LOC** 20.00 Max 172.50 7031.33 **8** 1.33 5th percentile 0.52 3.03 5 **8**

Sum ma ry

Data for Plotting on Figures

Percentile Rank Percentile Rank

1.33 5th percentile 0.52 3.03 5 **8** 86.25 10th percentile 0.87 7.10 10 **8** 17.00 20th percentile 2.17 24.00 20 **8** 17.50 50th percentile 10.00 148.40 50 **8** 35.00 95th percentile 98.67 5821.12 95 **8** 1.33 1.50

1.67

2.84
3.50
3.75 4.80 **14-DA**

**Y No Effects**  **Effects** 10.00 11.20 Min 0.25 0.15 For Plotting Distributions 11.67 Max 369.64 15067.14 **CE-LOC 15**  11.67 5th percentile 1.11 6.49 5 **15** 12.50 10th percentile 1.86 15.21 10 **15** 12.50 20th percentile 4.64 51.43 20 **15** 17.27 50th percentile 21.43 318.00 50 **15**17.92 95th percentile 211.43 12473.83 95 **15** 20.00
21.00
22.38 **7-DA**

**Y No Effects**  **Effects** 23.33 25.00 Min 0.50 0.30 For Plotting Distributions 26.67 Max 739.29 30134.29 **CE-LOC 18**  26.80 5th percentile 2.23 13.05 5 **18**

121.67 10th percentile 3.71 30.64 10 **18**

35.00 20th percentile 9.28 104.29 20 **18**
38.50 50th percentile 42.86 618.00 50 **18** 45.83 95th percentile 422.86 24385.77 95 **18** 46.82 54.60 70.00 **Ac tual Conc.**  **No Effects Effects**  70.00 74.20 Min 0.50 0.10 For Plotting Distributions 74.67 Max 207.00 10000.00 **CE-LOC 4**  100.00 5th percentile 0.60 10.00 5 **4** 116.67 10th percentile 1.40 20.00 10 **4** 117.95 20th percentile 2.96 30.00 20 **4** 130.67 50th percentile 10.00 100.00 50 **4** 142.80 95th percentile 100.00 4898.00 95 **4**
608.33
160.00
160.00
600.00 150.17 166.60 175.00
242.20

1133.33
1200.00
350.00
350.00 379.83 500.00
525.00
700.00 724.333041.67

1000.00 1166.67 1730.60
3500.00
3500.00 3515.67 0.30 0.040.10 1.00 10.00 100.00 1000.00 10000.00

0 10 20 30 40 50 60 70 80**C o** **n c** **e n** **t r** **a t** **i o** **n (** **u g** **/ L** **)**

**Percentile Rank** 

# Cosm E **ff ects and No E**  **ff ects Dis**  **tribution Normaliz**  **ed to a 60** 

**Da y Dur**  **ation. (Conc.*Dur** **ation/60)**

For Plotting Distributions **Percentile Rank**

10.00 100.00 1000.00 10000.00**C o** **n c** **e n** **t r** **a t** **i o** **n (** **u g** **/ L** **)** 

# Cosm E **ff ects and No E**  **ff ects Dis**  **tribution Normaliz**  **ed to a 30** 

**Da y Dur**  **ation. (Conc.*Dur** **ation/30)**For Plotting Distributions

For Plotting Distributions 0.10 1.00

0 10 20 30 40 50 60 70 80**C o** **n c** **e n** **t r** **a t** **i o** **n (** **u g** **/ L** **)**

**Percentile Rank**

100.00 1000.00 10000.00 100000.00**C o** **n c** **e n** **t r** **a t** **i o** **n (** **u g** **/ L** **)** 

# Cosm E **ff ects and No E**  **ff ects Dis**  **tribution Normaliz**  **ed to a 14** 

**Da y Dur**  **ation. (Conc.*Dur** **ation/14)**

1.00 10.00 100.00

0 10 20 30 40 50 60 70 80**C o** **n c** **e n** **t r** **a t** **i o** **n (** **u g** **/ L** **)**

**Percentile Rank**

100000.00 

# Cosm E **ff ects and No E**  **ff ects Dis**  **tribution Normaliz**  **ed to a 7** 

**Da y Dur**  **ation. (Conc.*Dur** **ation/7)**1.00 10.00 100.00 1000.00 10000.00

0 10 20 30 40 50 60 70 80**C o** **n c** **e n** **t r** **a t** **i o** **n (** **u g** **/ L** **)**

**Percentile Rank**

10000.00 

# Cosm E **ff ects and No E**  **ff ects Dis**  **tribution Over V**  **ariable Dur**  **ations. (Concentr**  **ation Re**  **port ed)** 

0.10 1.00 10.00 100.00 1000.00 10000.00

0 10 20 30 40 50 60 70 80**C o** **n c** **e n** **t r** **a t** **i o** **n (** **u g** **/ L** **)** 

# Cosm E **ff ects and No E**  **ff ects Dis**  **tribution Over V**  **ariable Dur**  **ations. (Concentr**  **ation Re**  **port ed)** 0 10 20 30 40 50 60 70 80 **Percentile Rank**90 100 

# Cosm E **ff ects and No E**  **ff ects Dis**  **tribution Normaliz**  **ed to a 60** 

**-**

Effects No Effects
CE

- LOC



# Cosm E **ff ects and No E**  **ff ects Dis**  **tribution Normaliz**  **ed to a 30** 

**-**

Effects No Effects CE

- LOC90 100



# Cosm E **ff ects and No E**  **ff ects Dis**  **tribution Normaliz**  **ed to a 14** 

**-**

Effects No Effects
CE

- LOC

90 100



# Cosm E **ff ects and No E**  **ff ects Dis**  **tribution Normaliz**  **ed to a 7** 

**-**90 100 Effects No Effects
CE

- LOC



# Cosm E **ff ects and No E**  **ff ects Dis**  **tribution Over V**  **ariable Dur**  **ations. (Concentr**  **ation Re**  **port ed)** 

90 100 

# Cosm E **ff ects and No E**  **ff ects Dis**  **tribution Over V**  **ariable Dur**  **ations. (Concentr**  **ation Re**  **port ed)** 

Effects No Effects
CE

- LOC90 100