EX-4.1




 Exhibit 4.1 

Execution Version 

AMYRIS, INC. 
 1.50%
CONVERTIBLE SENIOR NOTES DUE 2026 
 INDENTURE 

DATED AS OF NOVEMBER 15, 2021 

U.S. BANK NATIONAL ASSOCIATION, 

AS TRUSTEE 
  











 TABLE OF CONTENTS 

 
  

 

							
	 	 	 	  	PAGE	 
	
	ARTICLE 1	  

	
	DEFINITIONS AND INCORPORATION BY REFERENCE	  

			
	 Section 1.01.
	 	 Definitions
	  	 	1	 
	 Section 1.02.
	 	 Other Definitions
	  	 	10	 
	 Section 1.03.
	 	 Rules of Construction
	  	 	11	 
	 Section 1.04.
	 	 References to Additional Interest
	  	 	11	 
	
	ARTICLE 2	  

	
	THE SECURITIES	  

			
	 Section 2.01.
	 	 Form and Dating
	  	 	11	 
	 Section 2.02.
	 	 Execution and Authentication; Payments of Interest and Defaulted Amounts
	  	 	13	 
	 Section 2.03.
	 	 Registrar, Paying Agent and Conversion Agent
	  	 	15	 
	 Section 2.04.
	 	 Paying Agent to Hold Money in Trust
	  	 	16	 
	 Section 2.05.
	 	 Holder
	  	 	16	 
	 Section 2.06.
	 	 Transfer and Exchange; Transfer Restrictions
	  	 	17	 
	 Section 2.07.
	 	 Replacement Securities
	  	 	22	 
	 Section 2.08.
	 	 Outstanding Securities
	  	 	22	 
	 Section 2.09.
	 	 Treasury Securities
	  	 	23	 
	 Section 2.10.
	 	 Temporary Securities
	  	 	23	 
	 Section 2.11.
	 	 Cancellation; Repurchase
	  	 	23	 
	 Section 2.12.
	 	 Additional Transfer and Exchange Requirements
	  	 	24	 
	 Section 2.13.
	 	 CUSIP Numbers
	  	 	26	 
	
	ARTICLE 3	  

	
	OPTIONAL REDEMPTION; REPURCHASE UPON A FUNDAMENTAL CHANGE	  

			
	 Section 3.01.
	 	 Optional Redemption
	  	 	26	 
	 Section 3.02.
	 	 Notice of Optional Redemption; Selection of Securities
	  	 	26	 
	 Section 3.03.
	 	 Payment of Securities Called for Redemption
	  	 	28	 
	 Section 3.04.
	 	 Restrictions on Redemption
	  	 	28	 
	 Section 3.05.
	 	 Repurchase at Option of the Holder upon a Fundamental Change
	  	 	28	 
	 Section 3.06.
	 	 Compliance with Securities Laws upon Purchase of Securities
	  	 	31	 
	 Section 3.07.
	 	 No Repurchase upon Acceleration
	  	 	31	 
	 Section 3.08.
	 	 Repayment to the Company
	  	 	31	 
	 Section 3.09.
	 	 Partial Repurchase
	  	 	31	 


  
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	ARTICLE 4	  

	
	CONVERSION	  

			
	 Section 4.01.
	 	 Conversion Rights
	  	 	32	 
	 Section 4.02.
	 	 Settlement upon Conversion; Conversion Procedures
	  	 	35	 
	 Section 4.03.
	 	 Company to Provide Stock
	  	 	39	 
	 Section 4.04.
	 	 Adjustment to Conversion Rate upon a Make-Whole Fundamental Change or Redemption
Notice
	  	 	40	 
	 Section 4.05.
	 	 Conversion Rate Adjustments
	  	 	42	 
	 Section 4.06.
	 	 Adjustments of Prices
	  	 	53	 
	 Section 4.07.
	 	 Effect of Recapitalizations, Reclassifications and Changes of the Common Stock
	  	 	53	 
	 Section 4.08.
	 	 Cancellation of Converted Securities
	  	 	55	 
	 Section 4.09.
	 	 Shareholders Rights
	  	 	55	 
	 Section 4.10.
	 	 Trustee’s Disclaimer
	  	 	55	 
	 Section 4.11.
	 	 Exchange in Lieu of Conversion
	  	 	56	 
	
	ARTICLE 5	  

	
	COVENANTS	  

			
	 Section 5.01.
	 	 Payment on the Securities
	  	 	57	 
	 Section 5.02.
	 	 SEC Reports and Rule 144A Information Requirement
	  	 	57	 
	 Section 5.03.
	 	 Compliance Certificates
	  	 	59	 
	 Section 5.04.
	 	 Further Instruments and Acts
	  	 	60	 
	 Section 5.05.
	 	 Maintenance of Corporate Existence
	  	 	60	 
	 Section 5.06.
	 	 Stay, Extension and Usury Laws
	  	 	60	 
	
	ARTICLE 6	  

	
	CONSOLIDATION, MERGER, SALE, CONVEYANCE, TRANSFER OR LEASE	  

			
	 Section 6.01.
	 	 Company May Consolidate, Etc., Only on Certain Terms
	  	 	60	 
	 Section 6.02.
	 	 Successor Substituted
	  	 	61	 
	
	ARTICLE 7	  

	
	DEFAULT AND REMEDIES	  

			
	 Section 7.01.
	 	 Events of Default
	  	 	61	 
	 Section 7.02.
	 	 Acceleration
	  	 	62	 
	 Section 7.03.
	 	 Other Remedies
	  	 	63	 
	 Section 7.04.
	 	 Additional Interest
	  	 	63	 
	 Section 7.05.
	 	 Waiver of Defaults and Events of Default
	  	 	64	 
	 Section 7.06.
	 	 Control by Majority
	  	 	64	 
	 Section 7.07.
	 	 Limitations on Suits
	  	 	65	 
	 Section 7.08.
	 	 Rights of Holders to Receive Payment and to Convert
	  	 	65	 
	 Section 7.09.
	 	 Collection Suit by Trustee
	  	 	65	 
	 Section 7.10.
	 	 Trustee May File Proofs of Claim
	  	 	66	 


  
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	 Section 7.11.
	 	 Priorities
	  	 	66	 
	 Section 7.12.
	 	 Undertaking for Costs
	  	 	67	 
	
	ARTICLE 8	  

	
	TRUSTEE	  

			
	 Section 8.01.
	 	 Duties of Trustee
	  	 	67	 
	 Section 8.02.
	 	 Rights of Trustee
	  	 	68	 
	 Section 8.03.
	 	 Individual Rights of Trustee
	  	 	69	 
	 Section 8.04.
	 	 Trustee’s Disclaimer
	  	 	70	 
	 Section 8.05.
	 	 Notice of Default or Events of Default
	  	 	70	 
	 Section 8.06.
	 	 [Reserved]
	  	 	70	 
	 Section 8.07.
	 	 Compensation and Indemnity
	  	 	70	 
	 Section 8.08.
	 	 Replacement of Trustee
	  	 	71	 
	 Section 8.09.
	 	 Successor Trustee by Merger, Etc.
	  	 	72	 
	 Section 8.10.
	 	 Eligibility; Disqualification
	  	 	72	 
	
	ARTICLE 9	  

	
	SATISFACTION AND DISCHARGE OF INDENTURE	  

			
	 Section 9.01.
	 	 Satisfaction and Discharge of Indenture
	  	 	72	 
	 Section 9.02.
	 	 Application of Trust Money
	  	 	73	 
	 Section 9.03.
	 	 Repayment to Company
	  	 	73	 
	 Section 9.04.
	 	 Reinstatement
	  	 	73	 
	
	ARTICLE 10	  

	
	AMENDMENTS, SUPPLEMENTS AND WAIVERS	  

			
	 Section 10.01.
	 	 Without Consent of Holders
	  	 	74	 
	 Section 10.02.
	 	 With Consent of Holders
	  	 	75	 
	 Section 10.03.
	 	 [Reserved]
	  	 	76	 
	 Section 10.04.
	 	 Revocation and Effect of Consents
	  	 	76	 
	 Section 10.05.
	 	 Notation on or Exchange of Securities
	  	 	76	 
	 Section 10.06.
	 	 Trustee to Sign Amendments, Etc.
	  	 	76	 
	 Section 10.07.
	 	 Effect of Supplemental Indentures
	  	 	77	 
	
	ARTICLE 11	  

	
	MISCELLANEOUS	  

			
	 Section 11.01.
	 	 [Reserved]
	  	 	77	 
	 Section 11.02.
	 	 Notices
	  	 	77	 
	 Section 11.03.
	 	 Communications by Holders with Other Holders
	  	 	79	 
	 Section 11.04.
	 	 Certificate and Opinion as to Conditions Precedent
	  	 	79	 
	 Section 11.05.
	 	 Record Date for Vote or Consent of Holders
	  	 	80	 
	 Section 11.06.
	 	 Rules by Trustee, Paying Agent, Registrar and Conversion Agent
	  	 	80	 
	 Section 11.07.
	 	 Legal Holidays
	  	 	80	 


  
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	 Section 11.08.
	 	 Governing Law; Jurisdiction
	  	 	80	 
	 Section 11.09.
	 	 No Adverse Interpretation of Other Agreements
	  	 	81	 
	 Section 11.10.
	 	 Interpretation
	  	 	81	 
	 Section 11.11.
	 	 No Personal Liability of Directors, Officers, Employees or Shareholders
	  	 	81	 
	 Section 11.12.
	 	 Successors
	  	 	81	 
	 Section 11.13.
	 	 Multiple Counterparts
	  	 	81	 
	 Section 11.14.
	 	 Separability
	  	 	82	 
	 Section 11.15.
	 	 [Reserved.]
	  	 	82	 
	 Section 11.16.
	 	 Table of Contents, Headings, Etc.
	  	 	82	 
	 Section 11.17.
	 	 Force Majeure
	  	 	82	 
	 Section 11.18.
	 	 Waiver of Jury Trial
	  	 	82	 
	 Section 11.19.
	 	 Calculations
	  	 	82	 
	 Section 11.20.
	 	 U.S.A. PATRIOT Act
	  	 	83	 
		
	 EXHIBIT
	  			
		
	 Exhibit A – Form of Security
	  	 	A-1	 

  

  
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 INDENTURE, dated as of November 15, 2021, between AMYRIS, INC., a Delaware corporation
(the “Company,” as more fully set forth in Section 1.01), and U.S. Bank National Association, a national banking association, as trustee (the “Trustee,” as more fully set forth in Section 1.01). 

The Company and the Trustee agree as follows for the benefit of each other and for the equal and ratable benefit of the Holders of the
Company’s 1.50% Convertible Senior Notes due 2026 (as are issued under this Indenture, and as amended or supplemented from time to time, the “Securities”). 

ARTICLE 1 
 DEFINITIONS
AND INCORPORATION BY REFERENCE 
 Section 1.01. Definitions. 

“Additional Interest” means all amounts, if any, payable pursuant to Section 5.02(d), Section 5.02(e) and
Section 7.04, as applicable. 
 “Affiliate” means, with respect to any specified Person, any other Person directly or
indirectly controlling or controlled by or under direct or indirect common control with such specified Person. For the purposes of this definition, “control,” when used with respect to any Person, means the power to direct the management
and policies of such Person, directly or indirectly, whether through the ownership of voting securities, by contract or otherwise, and the terms “controlling” and “controlled” have meanings correlative to the foregoing. 

“Agent” means any Registrar, Paying Agent, Securities Custodian, Bid Solicitation Agent or Conversion Agent. 

“Applicable Procedures” means, with respect to any payment, tender, conversion, redemption, transfer or exchange of
beneficial ownership interests in a Global Security, the rules and procedures of the Depositary, in each case to the extent applicable to such payment, tender, conversion, redemption, transfer or exchange. 

“Authorized Officer” shall have the meaning specified in Section 11.02. 

“Bankruptcy Law” means Title 11 of the United States Code (or any successor thereto) or any similar federal or state law for
the relief of debtors. 
 “Bid Solicitation Agent” means the Person appointed by the Company to solicit bids for the
Trading Price of the Securities in accordance with Section 4.01(c). The Company shall initially act as the Bid Solicitation Agent. 

“Board of Directors” means either the board of directors of the Company or any committee of the board of directors of the
Company authorized to act for it with respect to this Indenture. 

  
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 “Business Day” means any day other than a Saturday, a Sunday or a day on
which the Federal Reserve Bank of New York is authorized or required by law or executive order to close or be closed. 
 “Called
Securities” means Securities called for Optional Redemption pursuant to Section 3.01 or subject to a Deemed Redemption. 

“Capital Stock” of any Person means (a) in the case of a corporation, corporate stock of such Person, (b) in the
case of an association or business entity, shares, interests, participations, rights or other equivalents (however designated) of corporate stock of such Person, (c) in the case of a partnership or limited liability company, partnership or
membership interests (whether general or limited) of such Person and (d) in the case of any other legal form, any other interest or participation of such Person that confers the right to receive a share of the profits and losses of, or
distribution of assets of, such Person. 
 “Cash” or “cash” means such coin or currency of the United
States as at any time of payment is legal tender for the payment of public and private debts. 
 “Certificated Security”
means a permanent certificated Security substantially in the form attached hereto as Exhibit A that is in registered form issued in denominations of $1,000 principal amount and integral multiples thereof. 

“close of business” means 5:00 p.m., New York City time. 

“Common Stock” means the common stock of the Company, $0.0001 par value per share, subject to Section 4.07. 

“Company” means the party named as such in the first paragraph of this Indenture until a successor replaces it pursuant to
the applicable provisions of this Indenture, and thereafter “Company” shall mean such successor Company. 
 “Conversion
Price” means as of any date $1,000, divided by the Conversion Rate as of such date. 
 “Corporate Trust
Office” means the office of the Trustee at the address specified in Section 11.02, and for Agent services such office shall also mean the office or agency of the Trustee in the contiguous United States located on the date hereof at 633
West Fifth Street, 24th floor, Los Angeles, CA 90071, Attn: B. Scarbrough (Amyris Convertible Senior Notes due 2026), or such other address as to which the Trustee may give notice to the Company.

 “Custodian” means any receiver, trustee, assignee, liquidator, sequestrator or similar official under any Bankruptcy
Law. 
 “Daily Conversion Value” means, for each of the 40 consecutive Trading Days during the Observation Period, 2.5% of
the product of (a) the Conversion Rate on such Trading Day and (b) the Daily VWAP for such Trading Day. 

  
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 “Daily Measurement Value” means the Specified Dollar Amount (if any),
divided by 40. 
 “Daily Settlement Amount,” for each of the 40 consecutive Trading Days during the Observation
Period, shall consist of: 
 (a) cash equal to the lesser of (i) the Daily Measurement Value and (ii) the Daily Conversion Value;
and 
 (b) if the Daily Conversion Value exceeds the Daily Measurement Value, a number of shares of Common Stock equal to (i) the
difference between the Daily Conversion Value and the Daily Measurement Value, divided by (ii) the Daily VWAP for such Trading Day. 

“Daily VWAP” means, for each of the 40 consecutive Trading Days during the relevant Observation Period, the per share
volume-weighted average price as displayed under the heading “Bloomberg VWAP” on Bloomberg page “AMRS <equity> AQR” (or any successor thereto) in respect of the period from the scheduled opening time of The Nasdaq Global
Select Market to the scheduled closing time of The Nasdaq Global Select Market on such Trading Day (or if such volume-weighted average price is unavailable at such time, the market value of one share of Common Stock on such Trading Day as
determined, using, if practicable, a volume-weighted average method, by a nationally recognized independent investment banking firm retained for this purpose by the Company). The “Daily VWAP” shall be determined without regard to
after-hours trading or any other trading outside of the regular trading session trading hours. 
 “Deemed Redemption” shall
have the meaning specified in Section 4.01(d). 
 “Default” or “default” means, when used with
respect to the Securities, any event that is or, after notice or passage of time or both, would be an Event of Default. 

“Defaulted Amounts” means any amounts on any Securities (including, without limitation, the Redemption Price, the Fundamental
Change Repurchase Price, principal and interest) that are payable but are not punctually paid or duly provided for. 

“delivered”, “given”, “mailed”, “notify”, or “sent”, with
respect to any notice to be delivered, given or mailed to a Holder pursuant to this Indenture, shall mean notice (x) given to the Depositary (or its designee) pursuant to the standing instructions from the Depositary or its designee, including
by electronic mail in accordance with accepted practices or procedures at the Depositary (in the case of a Global Security) or (y) mailed to such Holder by first class mail, postage prepaid, or delivered by guaranteed overnight courier, in each
case, at its address as it appears on the register (in the case of a Certificated Security), in each case in accordance with Section 11.02. Notice so “delivered” shall be deemed to include any notice to be “mailed” or
“given,” as applicable, under this Indenture. 
 “Effective Date” shall have the meaning specified in
Section 4.04(c), except that, as used in Section 4.05 and Section 4.06, “Effective Date” means the first date on which shares of the Common Stock trade on the applicable exchange or in the applicable market, regular
way, reflecting the relevant share split or share combination, as applicable. 

  
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 “Electronic Means” shall have the meaning specified in Section 11.02.

 “Ex-Dividend Date” means the first date on which the shares of the Common Stock
trade on the applicable exchange or in the applicable market, regular way, without the right to receive the issuance, dividend or distribution in question, from the Company or, if applicable, from the seller of Common Stock on such exchange or
market (in the form of due bills or otherwise) as determined by such exchange or market. 
 “Exchange Act” means the
Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated thereunder, as in effect from time to time. 

“Exchange in Lieu of Conversion” shall have the meaning specified in Section 4.11(a). 

“Fundamental Change” shall be deemed to have occurred at the time after the Securities are originally issued if any of the
following occurs: 
 (a) the Common Stock (or other Reference Property into which the Securities are then convertible) ceases to be listed on
any of The New York Stock Exchange, The Nasdaq Global Select Market or The Nasdaq Global Market (or any of their respective successors); 

(b) any Person, including any group deemed to be a “person” under Section 13(d)(3) of the Exchange Act, acquires beneficial
ownership, directly or indirectly, through a purchase, merger or other acquisition transaction or series of transactions or otherwise, of shares of Common Stock representing 50% or more of the total voting power of all shares of Common Stock, other
than an acquisition by the Company or any of its Wholly Owned Subsidiaries; 
 (c) the (i) consolidation, share exchange or merger of
the Company pursuant to which the Common Stock is converted into cash, securities or other property, (ii) the sale, lease, transfer, conveyance or other disposition, in one or a series of related transactions, of all or substantially all of the
Company’s and the Company’s Subsidiaries’ assets, taken as a whole, to any “person” (as this term is used in Section 13(d)(3) of the Exchange Act) or (iii) any recapitalization, reclassification or change of the
Common Stock (other than changes resulting from a subdivision or combination) as a result of which the Common Stock would be converted into, or exchanged for, stock, other securities, other property or assets; provided that, with respect to
clause (i), any transaction pursuant to which the holders of 50% or more of the total voting power of all shares of the Company’s Capital Stock entitled to vote generally in elections of directors immediately prior to such transaction have the
right to exercise, directly or indirectly, 50% or more of the total voting power of all shares of the Company’s Capital Stock (or other securities issued in such transaction) entitled to vote generally in elections of directors of the
continuing or surviving person or the parent entity thereof immediately after giving effect to such transaction, in substantially the same proportions as such ownership immediately prior to such transaction, shall not constitute a “Fundamental
Change”; or 
 (d) the Company’s stockholders approve any plan or proposal for the liquidation or dissolution of the Company; 

  
 4 












 provided, however, that a transaction or transactions described in clause (c) above shall
not constitute a Fundamental Change and Holders shall not have the right to require the Company to repurchase any Securities (and the Company shall not be required to deliver the Fundamental Change Repurchase Right Notice incidental thereto under
Section 3.05(b)) if at least 90% of the consideration paid for the Common Stock (excluding cash payments for fractional shares and cash payments made pursuant to dissenters’ or appraisal rights) in connection with such transaction or
transactions consists of shares of common stock that are listed or quoted on any of The New York Stock Exchange, The Nasdaq Global Select Market or The Nasdaq Global Market (or any of their respective successors) or will be so traded or quoted
immediately following such transaction or transactions and, as a result of such transaction or transactions, such consideration, excluding cash payments for fractional shares and cash payments made pursuant to dissenters’ or appraisal rights,
becomes the Reference Property pursuant to Section 4.07. In addition, for purposes of this definition, a transaction or event that constitutes a Fundamental Change under both clause (b) and clause (c) above (without regard to the
proviso in clause (c) above) and does not constitute a Fundamental Change under clause (c) above by reason of the proviso in clause (c) above will also not be deemed to constitute a Fundamental Change solely under clause
(b) of this definition of Fundamental Change. For purposes of this definition, whether a Person is a “beneficial owner” will be determined in accordance with Rule 13d-3 under the Exchange Act,
and “Person” includes any syndicate or group that would be deemed to be a “person” under Section 13(d)(3) of the Exchange Act. 

“GAAP” means generally accepted accounting principles in the United States of America as in effect as of the date of this
Indenture, including those set forth in (1) the opinions and pronouncements of the Accounting Principles Board of the American Institute of Certified Public Accountants, (2) the statements and pronouncements of the Financial Accounting
Standards Board, (3) such other statements by such other entity as approved by a significant segment of the accounting profession and (4) the rules and regulations of the SEC governing the inclusion of financial statements (including pro
forma financial statements) in registration statements filed under the Securities Act and periodic reports required to be filed pursuant to Section 13 of the Exchange Act, including opinions and pronouncements in staff accounting bulletins and
similar written statements from the accounting staff of the SEC. 
 “Global Security” means a permanent Security in
substantially the form attached hereto as Exhibit A that is deposited with the Depositary or its custodian and registered in the name of the Depositary or its nominee. 

“Holder” means the Person in whose name a Security is registered on the Primary Registrar’s books. 

“Indenture” means this Indenture as amended or supplemented from time to time pursuant to the terms of this Indenture. 

“Instructions” shall have the meaning specified in Section 11.02. 

“Interest Payment Date” means each May 15 and November 15 of each year, beginning on May 15, 2022. 

  
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 “Last Reported Sale Price” of the Common Stock on any date means the
closing sale price per share (or if no closing sale price is reported, the average of the bid and ask prices or, if more than one in either case, the average of the average bid and the average ask prices) on that date as reported in composite
transactions for the principal U.S. national or regional securities exchange on which the Common Stock is traded. If the Common Stock is not listed for trading on a U.S. national or regional securities exchange on the relevant date, the
“Last Reported Sale Price” shall be the last quoted bid price for the Common Stock in the over-the-counter market on the relevant date as reported by
OTC Markets Group Inc. or a similar organization. If the Common Stock is not so quoted, the “Last Reported Sale Price” shall be the average of the mid-point of the last bid and ask prices for
the Common Stock on the relevant date from each of at least three nationally recognized independent investment banking firms selected by the Company for this purpose. 

“Legal Holiday” is any day other than a Business Day. 

“Make-Whole Fundamental Change” means any transaction or event that constitutes a Fundamental Change (as defined above and
determined after giving effect to any exceptions to or exclusions from such definition, but without regard to the proviso in clause (c) of the definition thereof). 

“Market Disruption Event” means (a) a failure by the primary U.S. national or regional securities exchange or market on
which the Common Stock is listed or admitted for trading to open for trading during its regular trading session or (b) the occurrence or existence prior to 1:00 p.m., New York City time, on any Scheduled Trading Day for the Common Stock for
more than one half-hour period in the aggregate during regular trading hours of any suspension or limitation imposed on trading (by reason of movements in price exceeding limits permitted by the relevant stock exchange or otherwise) in the Common
Stock or in any options contracts or future contracts relating to the Common Stock. 
 “Maturity Date” means
November 15, 2026. 
 “Observation Period” with respect to any Security surrendered for conversion means:
(a) subject to clause (b), if the relevant Conversion Date occurs prior to June 15, 2026, the 40 consecutive Trading Day period beginning on, and including, the second Trading Day immediately succeeding such Conversion Date; (b) with
respect to any Called Securities, if the relevant Conversion Date occurs during the related Redemption Period, the 40 consecutive Trading Days beginning on, and including, the 41st Scheduled Trading Day immediately preceding the related Redemption
Date; and (c) subject to clause (b), if the relevant Conversion Date occurs on or after June 15, 2026, the 40 consecutive Trading Days beginning on, and including, the 41st Scheduled Trading Day immediately preceding the Maturity Date.

 “Officer” means the Chairman of the Board, the Chief Executive Officer, the President, any Vice President, the Chief
Operating Officer, the Chief Financial Officer, the Treasurer, any Assistant Treasurer, the Controller, the Secretary or any Assistant Secretary of the Company. 

“Officers’ Certificate” means a certificate signed on behalf of the Company by at least two Officers that meets the
requirements of Section 11.04. 
 “open of business” means 9:00 a.m., New York City time. 

  
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 “Opinion of Counsel” means a written opinion that meets the requirements of
Section 11.04 from legal counsel. The counsel may be an employee of or counsel to the Company or any Subsidiary of the Company, or other counsel who is acceptable to the Trustee. 

“Optional Redemption” shall have the meaning specified in Section 3.01. 

“Partial Redemption Limitation” shall have the meaning specified in Section 3.02(d). 

“Person” means any individual, corporation, partnership, limited liability company, joint venture, association, joint-stock
company, trust, unincorporated organization, government or any agency or political subdivision thereof or any other entity. 

“Principal” or “principal” of a debt security, including the Securities, means the principal of the
security, plus, when appropriate, the premium, if any, on such security. 
 “Record Date” means, with respect to any
dividend, distribution or other transaction or event in which the holders of Common Stock (or other applicable security) have the right to receive any cash, securities or other property or in which the Common Stock (or such other security) is
exchanged for or converted into any combination of cash, securities or other property, the date fixed for determination of holders of Common Stock (or such other security) entitled to receive such cash, securities or other property (whether such
date is fixed by the Board of Directors, by statute, by contract or otherwise). 
 “Redemption Date” shall have the meaning
specified in Section 3.02(a). 
 “Redemption Notice” shall have the meaning specified in Section 3.02(a). 

“Redemption Period” means, with respect to any Redemption Notice, the period beginning on, and including, the date of such
Redemption Notice and ending at the close of business on the Scheduled Trading Day prior to the related Redemption Date (or, if the Company defaults in the payment of the Redemption Price, until the Redemption Price has been paid or duly provided
for). 
 “Redemption Price” means, for any Securities to be redeemed pursuant to Section 3.01, 100% of the principal
amount of such Securities, plus accrued and unpaid interest, if any, to, but excluding, the Redemption Date (unless the Redemption Date falls after a Regular Record Date but on or prior to the immediately succeeding Interest Payment Date, in
which case interest accrued to the Interest Payment Date will be paid to Holders of record of such Securities as of the close of business on such Regular Record Date, and the Redemption Price will be equal to 100% of the principal amount of such
Securities). 
 “Regular Record Date,” with respect to any Interest Payment Date, shall mean the May 1 or
November 1 (whether or not such day is a Business Day) immediately preceding the applicable May 15 or November 15 Interest Payment Date, respectively. 

“Resale Restriction Termination Date” shall have the meaning specified in Section 2.06(d). 

  
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 “Responsible Officer,” when used with respect to the Trustee, means any
officer within the Corporate Trust Office of the Trustee having direct responsibility for the administration of this Indenture, or any other officer to whom such matter relating to this Indenture is referred because of his or her knowledge of and
familiarity with the particular subject. 
 “Restricted Securities” shall have the meaning specified in
Section 2.06(d). 
 “Rule 144” means Rule 144 as promulgated under the Securities Act. 

“Rule 144A” means Rule 144A as promulgated under the Securities Act. 

“Scheduled Trading Day” means a day that is scheduled to be a Trading Day on the principal U.S. national or regional
securities exchange or market on which the Common Stock is listed or admitted for trading. If the Common Stock is not so listed or admitted for trading, “Scheduled Trading Day” means a Business Day. 

“SEC” means the U.S. Securities and Exchange Commission. 

“Securities Act” means the Securities Act of 1933, as amended, and the rules and regulations promulgated thereunder, as in
effect from time to time. 
 “Securities Custodian” means the Trustee, as custodian for DTC, with respect to any Global
Security, or any successor thereto. 
 “Settlement Method” means, with respect to any conversion of the Securities,
Physical Settlement, Cash Settlement or Combination Settlement, as elected (or deemed to have been elected) by the Company. 

“Significant Subsidiary” means, in respect of any Person, a Subsidiary of such Person that would constitute a
“significant subsidiary,” as such term is defined in Rule 1-02 of Regulation S-X under the Exchange Act; provided that, in the case of a Subsidiary
that meets the criteria of clause (1)(iii) of the definition thereof but not clause (1)(i) or (1)(ii) thereof, such Subsidiary shall not be deemed to be a Significant Subsidiary unless the Subsidiary’s income from continuing operations before
income taxes exclusive of amounts attributable to any non-controlling interests for the last completed fiscal year prior to the date of such determination exceeds $30,000,000 (or its foreign currency
equivalent). For the avoidance of doubt, to the extent any such Subsidiary would not be deemed to be a “Significant Subsidiary” under the relevant definition set forth in Article 1, Rule
1-02(w) of Regulation S-X (or any successor rule) as in effect on the relevant date of determination, such Subsidiary shall not be deemed to be a “Significant
Subsidiary” under this Indenture irrespective of whether such Subsidiary has greater than $30,000,000 (or its foreign currency equivalent) in income from continuing operations as described in the immediately preceding sentence. 

“Specified Dollar Amount” means the maximum cash amount per $1,000 principal amount of Securities to be received upon
conversion as specified (or deemed specified) in the Settlement Notice related to any converted Securities. 

  
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 “Subsidiary” means, in respect of any Person, any corporation, association,
partnership or other business entity of which more than 50% of the total voting power of shares of Capital Stock or other interests (including partnership interests) entitled (without regard to the occurrence of any contingency) to vote in the
election of directors, managers, general partners or trustees thereof is at the time owned or controlled, directly or indirectly, by (a) such Person; (b) such Person and one or more Subsidiaries of such Person; or (c) one or more
Subsidiaries of such Person. 
 “Successor Company” shall have the meaning specified in Section 6.01(a). 

“Trading Day” means a day on which (a) trading in the Common Stock (or other security for which a Last Reported Sale
Price must be determined) generally occurs on The Nasdaq Global Select Market or, if the Common Stock (or such other security) is not then listed on The Nasdaq Global Select Market, on the principal other U.S. national or regional securities
exchange on which the Common Stock (or such other security) is then listed or, if the Common Stock (or such other security) is not then listed on a U.S. national or regional securities exchange, on the principal other market on which the Common
Stock (or such other security) is then traded and (b) a Last Reported Sale Price for the Common Stock (or such other security) is available on such securities exchange or market; provided that if the Common Stock (or such other security)
is not so listed or traded, “Trading Day” means a Business Day; and provided further that for purposes of determining amounts due upon conversion only, “Trading Day” means a day on which (i) there is no
Market Disruption Event and (ii) trading in the Common Stock generally occurs on The Nasdaq Global Select Market or, if the Common Stock is not then listed on The Nasdaq Global Select Market, on the principal other U.S. national or regional
securities exchange on which the Common Stock is then listed or, if the Common Stock is not then listed on a U.S. national or regional securities exchange, on the principal other market on which the Common Stock is then listed or admitted for
trading, except that if the Common Stock is not so listed or admitted for trading, “Trading Day” means a Business Day. 

“Trading Price” per $1,000 principal amount of Securities on any date of determination means the average of the secondary
market bid quotations obtained by the Bid Solicitation Agent for $2.0 million principal amount of Securities at approximately 3:30 p.m., New York City time, on such determination date from three independent nationally recognized securities
dealers the Company selects for this purpose; provided that if three such bids cannot reasonably be obtained by the Bid Solicitation Agent but two such bids are obtained, then the average of the two bids shall be used, and if only one such
bid can reasonably be obtained by the Bid Solicitation Agent, that one bid shall be used. If the Bid Solicitation Agent cannot reasonably obtain at least one bid for $2.0 million principal amount of Securities from a nationally recognized
securities dealer, then the Trading Price per $1,000 principal amount of Securities shall be deemed to be less than 98% of the product of the Last Reported Sale Price of the Common Stock and the Conversion Rate. 

“transfer” shall have the meaning specified in Section 2.06(d). 

“Trustee” means the party named as such in the first paragraph of this Indenture until a successor trustee shall have become
such pursuant to the applicable provisions of this Indenture, and thereafter shall mean or include each Person who is then a Trustee hereunder. 

  
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 “Vice President” when used with respect to the Company or the Trustee,
means any vice president, whether or not designated by a number or a word or words added before or after the title “vice president.” 

“Wholly Owned Subsidiary” means, with respect to any Person, any Subsidiary of such Person, except that, solely for purposes
of this definition, the reference to “more than 50%” in the definition of “Subsidiary” shall be deemed replaced by a reference to “100%”. 

Section 1.02. Other Definitions. 
  

			
	 Term
	  	 Where Defined

	“Additional Shares”	  	4.04(a)
	“Agent Members”	  	2.01(b)
	“Cash Settlement”	  	4.02(a)
	“Clause A Distribution”	  	4.05(c)
	“Clause B Distribution”	  	4.05(c)
	“Clause C Distribution”	  	4.05(c)
	“Combination Settlement”	  	4.02(a)
	“Company Order”	  	2.02(c)
	“Conversion Agent”	  	2.03
	“Conversion Date”	  	4.02(c)
	“Conversion Notice”	  	4.02(b)
	“Conversion Obligation”	  	4.01(a)
	“Conversion Rate”	  	4.01(a)
	“Depositary”	  	2.01(b)
	“Distributed Property”	  	4.05(c)
	“DTC”	  	2.01(b)
	“Event of Default”	  	7.01
	“Fundamental Change Repurchase Date”	  	3.05(d)
	“Fundamental Change Repurchase Price”	  	3.05(a)
	“Fundamental Change Repurchase Right Notice”	  	3.05(b)
	“Measurement Period”	  	4.01(c)
	“Merger Event”	  	4.07(a)
	“Non-Separate Rights”	  	4.09
	“Paying Agent”	  	2.03
	“Physical Settlement”	  	4.02(a)
	“Primary Registrar”	  	2.03
	“Reference Property”	  	4.07(a)
	“Registrar”	  	2.03
	“Repurchase Exercise Notice”	  	3.05(c)
	“Securities”	  	Recitals
	“Settlement Amount”	  	4.02(a)(ii)
	“Settlement Notice”	  	4.02(a)(i)
	“Spin-Off”	  	4.05(c)
	“Stock Price”	  	4.04(c)
	“Trigger Event”	  	4.05(c)
	“unit of Reference Property”	  	4.07(a)
	“Valuation Period”	  	4.05(c)


  
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 Section 1.03. Rules of Construction. Unless the context otherwise requires: 

(a) a term has the meaning assigned to it; 

(b) an accounting term not otherwise defined has the meaning assigned to it in accordance with GAAP; 

(c) words in the singular include the plural, and words in the plural include the singular; 

(d) provisions apply to successive events and transactions; 

(e) the term “merger” includes a statutory share exchange and the term “merged” has a correlative meaning; 

(f) the masculine gender includes the feminine and the neuter; 

(g) references to agreements and other instruments include subsequent amendments thereto; and 

(h) “herein,” “hereof,” “hereunder” and other words of similar import refer to this Indenture as a whole and not
to any particular Article, Section or other subdivision. 
 Section 1.04. References to Additional Interest. Unless the context
otherwise requires, any reference to interest on, or in respect of, any Security in this Indenture shall be deemed to include Additional Interest if, in such context, Additional Interest is, was or would be payable pursuant to any of
Section 5.02(d), Section 5.02(e) or Section 7.04, as applicable. Unless the context otherwise requires, any express mention of Additional Interest in any provision hereof shall not be construed as excluding Additional Interest in
those provisions hereof where such express mention is not made. 
 ARTICLE 2 

THE SECURITIES 

Section 2.01. Form and Dating. (a) The Securities and the Trustee’s certificate of authentication shall be substantially
in the respective forms set forth in Exhibit A, which Exhibit is incorporated in and made part of this Indenture. The Securities may have notations, legends or endorsements required by law, stock exchange rule or usage. The Company shall provide any
such notations, legends or endorsements to the Trustee in writing. Each Security shall be dated the date of its authentication. The terms and provisions contained in the Securities shall constitute, and are hereby expressly made, a part of this
Indenture, and the Company and the Trustee, by their execution and delivery of this Indenture, expressly agree to such terms and 

  
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provisions and to be bound thereby. Any Security may be endorsed with or have incorporated in the text thereof such legends or recitals or changes not inconsistent with the provisions of this
Indenture as may be required by the Securities Custodian or the Depositary, or as may be required to comply with any applicable law or any regulation thereunder or with the rules and regulations of any securities exchange or automated quotation
system upon which the Securities may be listed or traded or designated for issuance or to conform with any usage with respect thereto, or to indicate any special limitations or restrictions to which any particular Securities are subject. 

(b) All of the Securities shall be issued initially in the form of one or more Global Securities, without interest coupons, which shall be
deposited on behalf of the purchasers of the Securities represented thereby with the Securities Custodian, at its Corporate Trust Office, as custodian for The Depository Trust Company (“DTC”) (such depositary, or any successor
thereto, being hereinafter referred to as the “Depositary”), and registered in the name of its nominee, Cede & Co., duly executed by the Company and authenticated by the Trustee as hereinafter provided. The Company has
entered into a letter of representations with DTC in the form provided by DTC and the Trustee and each Agent are hereby authorized to act in accordance with such letter and the Applicable Procedures. 

Each Global Security shall represent such of the outstanding Securities as shall be specified therein and each shall provide that it shall
represent the aggregate amount of outstanding Securities from time to time endorsed thereon and that the aggregate amount of outstanding Securities represented thereby may from time to time be reduced or increased, as appropriate, to reflect
exchanges, purchases, redemptions, or conversions of such Securities. Any adjustment of the aggregate principal amount of a Global Security to reflect the amount of any increase or decrease in the amount of outstanding Securities represented thereby
shall be made by the Trustee in accordance with instructions given by the Holder thereof as required by Section 2.12 and shall be made on the records of the Trustee and the Depositary. 

Members of, or participants in, the Depositary (“Agent Members”) shall have no rights under this Indenture with respect to
any Global Security held on their behalf by the Depositary or under the Global Security, and the Depositary (including, for this purpose, its nominee) may be treated by the Company, the Trustee and any agent of the Company or the Trustee as the
absolute owner and Holder of such Global Security for all purposes whatsoever. Notwithstanding the foregoing, nothing herein shall (1) prevent the Company, the Trustee or any agent of the Company or the Trustee from giving effect to any written
certification, proxy or other authorization furnished by the Depositary or (2) impair, as between the Depositary and its Agent Members, the operation of customary practices governing the exercise of the rights of a Holder of any Security. 

(c) The Company shall execute and the Trustee shall, in accordance with this Section 2.01(c), authenticate and deliver initially one or
more Global Securities that (1) shall be registered in the name of the Depositary, (2) shall be delivered by the Trustee to the Depositary or pursuant to the Depositary’s instructions and (3) shall bear a legend substantially to
the following effect: 

  
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 “UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY
TRUST COMPANY TO THE COMPANY OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE
DEPOSITORY TRUST COMPANY (AND ANY PAYMENT HEREON IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE
BY OR TO ANY PERSON IS WRONGFUL SINCE THE REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN. THIS SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A
DEPOSITARY OR A NOMINEE THEREOF. THIS SECURITY IS EXCHANGEABLE FOR SECURITIES REGISTERED IN THE NAME OF A PERSON OTHER THAN THE DEPOSITARY OR ITS NOMINEE ONLY IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE AND, UNLESS AND UNTIL IT IS
EXCHANGED IN WHOLE OR IN PART FOR SECURITIES IN DEFINITIVE FORM, THIS SECURITY MAY NOT BE TRANSFERRED EXCEPT AS A WHOLE BY THE DEPOSITARY TO A NOMINEE OF THE DEPOSITARY OR BY A NOMINEE OF THE DEPOSITARY TO THE DEPOSITARY OR ANOTHER NOMINEE OF THE
DEPOSITARY OR BY THE DEPOSITARY OR ANY SUCH NOMINEE TO A SUCCESSOR DEPOSITARY OR A NOMINEE OF SUCH SUCCESSOR DEPOSITARY.” 

Section 2.02. Execution and Authentication; Payments of Interest and Defaulted Amounts. (a) The Securities shall be issuable
only in registered form without coupons and only in denominations of $1,000 principal amount and any integral multiple thereof. An Officer shall sign the Securities for the Company by manual, facsimile or other electronic signature. Typographic and
other minor errors or defects in any such facsimile signature shall not affect the validity or enforceability of any Security which has been authenticated and delivered by the Trustee. If an Officer whose signature is on a Security no longer holds
that office at the time the Trustee authenticates the Security, the Security shall be valid nevertheless. A Security shall not be valid until an authorized signatory of the Trustee manually signs the certificate of authentication on the Security.
The signature shall be conclusive evidence that the Security has been authenticated under this Indenture. 
 (b) The Trustee shall act as the
initial authenticating agent. Thereafter, the Trustee may appoint an authenticating agent acceptable to the Company to authenticate Securities. An authenticating agent may authenticate Securities whenever the Trustee may do so. Each reference in
this Indenture to authentication by the Trustee includes authentication by such agent. An authenticating agent shall have the same rights as an Agent to deal with the Company or an Affiliate of the Company. 

(c) The Trustee shall authenticate and make available for delivery Securities for original issue in the aggregate principal amount of up to
$690,000,000 upon receipt of a written order or orders of the Company signed by at least two Officers (a “Company Order”). The Company Order shall specify the amount of Securities to be authenticated, shall provide that all such
Securities will be represented by a Global Security and the date on which each original 

  
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issue of Securities is to be authenticated. The Company at any time or from time to time may, without the consent of the Holders, reopen this Indenture and issue additional Securities under this
Indenture having the same ranking, interest rate, Maturity Date and other terms as the Securities initially issued hereunder (other than differences in the issue date, issue price and interest accrued prior to the issue date of such additional
Securities) in an unlimited aggregate principal amount, and entitled to all of the benefits of this Indenture; provided that if any such additional Securities are not fungible with the Securities initially issued hereunder for U.S. federal
income tax purposes or securities laws purposes, such additional Securities shall have a separate CUSIP number. Such additional Securities shall, together with the Securities initially issued hereunder, constitute a single series of Securities under
this Indenture, including without limitation in determining the necessary Holders who may take the actions or consent to the taking of actions as specified in this Indenture. In authenticating such Securities, and accepting the additional
responsibilities under this Indenture in relation to such additional Securities, the Trustee shall receive, and, shall be fully protected in relying upon, (a) an Officers’ Certificate delivered in accordance with Section 2.01 and
Section 11.04 and (b) an Opinion of Counsel which shall state (1) that the form and terms of such Securities have been established by or pursuant to a resolution of the Board of Directors in accordance with Section 2.01 and
Section 2.02 and in conformity with the provisions of this Indenture, (2) that such Securities, when authenticated and delivered by the Trustee and issued by the Company in the manner and subject to any conditions specified in such Opinion
of Counsel, will constitute valid and legally binding obligations of the Company, enforceable in accordance with their terms, subject to bankruptcy, insolvency, reorganization and other laws of general applicability relating to or affecting the
enforcement of creditors’ rights and to general equity principles, and (3) that all conditions precedent under this Indenture in respect of the execution and delivery by the Company of such Securities have been complied with. 

(d) Accrued interest on the Securities shall be computed on the basis of a 360-day year composed of
twelve 30-day months and for partial months, on the basis of the number of days actually elapsed in a 30-day month. The Person in whose name any Security (or its
predecessor) is registered on the register of the Primary Registrar at the close of business on any Regular Record Date with respect to any Interest Payment Date shall be entitled to receive the interest payable on such Interest Payment Date.
Interest shall be payable at the office or agency of the Company maintained by the Company for such purposes in the contiguous United States, which shall initially be the Corporate Trust Office. The Company shall pay interest (i) on any
Certificated Securities by check mailed to the address of the registered Holder of such Security; provided, however, that the Company will pay interest to any Holder of more than $2,000,000 aggregate principal amount of Certificated
Securities by wire transfer in immediately available funds to an account within the United States designated by such Holder in a written application delivered by such Holder to the Trustee and the Paying Agent not later than the Regular Record Date
for the relevant Interest Payment Date, which application will remain in effect until such Holder notifies the Trustee and Paying Agent, in writing, to the contrary or (ii) on any Global Security by wire transfer of immediately available funds
to the account of the Depositary or its nominee. 
 (e) Any Defaulted Amounts shall forthwith cease to be payable to the Holder on the
relevant payment date by virtue of its having been such Holder but shall accrue interest per annum at the rate borne by the Securities, subject to the enforceability thereof under applicable law, from, and including, such relevant payment date to,
but excluding, the date on which such Defaulted Amounts shall have been paid by the Company, at its election in each case, as provided in subsection (i) or (ii) below: 

  
 14 












 (i) The Company may elect to make payment of any Defaulted Amounts to the
Persons in whose names the Securities (or their respective predecessor Securities) are registered at the close of business on a special record date for the payment of such Defaulted Amounts, which shall be fixed in the following manner. The Company
shall notify the Trustee in writing of the amount of the Defaulted Amounts proposed to be paid on each Security and the date of the proposed payment (which shall be not less than 15 days after the receipt by the Trustee of such notice, unless the
Trustee shall consent to an earlier date), and at the same time the Company shall deposit with the Trustee an amount of money equal to the aggregate amount to be paid in respect of such Defaulted Amounts or shall make arrangements satisfactory to
the Trustee for such deposit on or prior to the date of the proposed payment, such money when deposited to be held in trust for the benefit of the Persons entitled to such Defaulted Amounts as in this clause provided. Thereupon the Company shall fix
a special record date for the payment of such Defaulted Amounts which shall be not more than 15 days and not less than 10 days prior to the date of the proposed payment, and not less than 10 days after the receipt by the Trustee of the notice of the
proposed payment. The Company shall promptly notify the Trustee of such special record date and shall cause notice of the proposed payment of such Defaulted Amounts and the special record date therefor to be delivered to each Holder, not less than
10 days prior to such special record date. Notice of the proposed payment of such Defaulted Amounts and the special record date therefor having been so delivered, such Defaulted Amounts shall be paid to the Persons in whose names the Securities (or
their respective predecessor Securities) are registered at the close of business on such special record date and shall no longer be payable pursuant to the following subsection (ii) of this Section 2.02(e). 

(ii) The Company may make payment of any Defaulted Amounts in any other lawful manner not inconsistent with the requirements of
any securities exchange or automated quotation system on which the Securities may be listed or designated for issuance, and upon such notice as may be required by such exchange or automated quotation system, if, after notice given by the Company to
the Trustee of the proposed payment pursuant to this clause, such manner of payment shall be deemed practicable by the Trustee. 

Section 2.03. Registrar, Paying Agent and Conversion Agent. The Company shall maintain one or more offices or agencies where
Securities may be presented on the Maturity Date, upon redemption, for registration of transfer or exchange or conversion (each, a “Registrar”), one or more offices or agencies where Securities may be presented for payment (each, a
“Paying Agent”), one or more offices or agencies where Securities may be presented for conversion (each, a “Conversion Agent”) and one or more offices or agencies where notices and demands to or upon the Company in
respect of the Securities and this Indenture may be served, such offices and agencies to be maintained in the contiguous United States. The Company will at all times maintain a Paying Agent, Conversion Agent, Registrar and an office or agency where
notices and demands to or upon the Company in respect of the Securities and this Indenture may be served. One of the Registrars (the “Primary Registrar”) shall keep a register of the Securities and of their registration of transfer
and exchange. The Company shall give prompt written notice to the Trustee of the location, and any change in the location, of such office or agency. 

  
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 The Company shall enter into an appropriate agency agreement with any Agent not a party to
this Indenture. The agreement shall implement the provisions of this Indenture that relate to such Agent. The Company shall give prompt written notice to the Trustee of the name and address of any Agent not a party to this Indenture. If the Company
fails to maintain a Registrar, Paying Agent, Conversion Agent or agent for service of notices and demands in any place required by this Indenture, or fails to give the foregoing notice, the Trustee shall act as such. The Company or any Affiliate of
the Company may act as Paying Agent or Bid Solicitation Agent (except for the purposes of Section 5.01 and Article 9). Upon any bankruptcy, reorganization or similar proceeding with respect to the Company, the Trustee shall automatically serve
as Paying Agent for the Securities. 
 The Company hereby initially designates the Trustee as Paying Agent, Primary Registrar, Securities
Custodian and Conversion Agent and the Corporate Trust Office of the Trustee as the office or agency of the Company in the contiguous United States for each of the aforesaid purposes, provided, that the Corporate Trust Office of the Trustee shall
not be the office or agency of the Company for the service of legal process. The Company shall initially act as the Bid Solicitation Agent under this Indenture. 

Section 2.04. Paying Agent to Hold Money in Trust. Prior to 12:00 p.m., New York City time, on each due date of the principal of
or interest on any Securities, the Company shall deposit with a Paying Agent a sum sufficient to pay such principal or interest so becoming due. A Paying Agent shall segregate and hold in trust for the benefit of the Holders or the Trustee all money
held by the Paying Agent for the payment of principal of or interest on the Securities, and shall notify the Trustee of any default by the Company (or any other obligor on the Securities) in making any such payment. If the Company or an Affiliate of
the Company acts as Paying Agent, it shall, before 12:00 p.m., New York City time, on each due date of the principal of or interest on any Securities, segregate the money and hold it as a separate trust fund for the benefit of the Holders. The
Company at any time may require a Paying Agent to pay all money held by it to the Trustee, and the Trustee may at any time during the continuance of any default, upon written request to a Paying Agent, require such Paying Agent to pay forthwith to
the Trustee all sums so held in trust by such Paying Agent. Upon doing so, the Paying Agent (other than the Company) shall have no further liability for the money. 

Section 2.05. Holder. The Trustee shall preserve in as current a form as is reasonably practicable the most recent list available
to it of the names and addresses of the Holders. If the Trustee is not the Primary Registrar, the Company shall furnish to the Trustee at least seven Business Days before each Interest Payment Date, and at such other times as the Trustee may request
in writing, a list in such form and as of such date as the Trustee may reasonably require of the names and addresses of the Holders. 

  
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 Section 2.06. Transfer and Exchange; Transfer Restrictions. (a) Subject to
compliance with any applicable additional requirements contained in Section 2.12, when a Security is presented to a Registrar with a request to register a transfer thereof or to exchange such Security for an equal principal amount of Securities
of other authorized denominations, the Registrar shall register the transfer or make the exchange as requested; provided, however, that every Security presented or surrendered for registration of transfer or exchange shall be duly
endorsed or accompanied by an assignment form in form satisfactory to the Registrar duly executed by the Holder thereof or its attorney duly authorized in writing. To permit registration of transfers and exchanges, upon surrender of any Security for
registration of transfer or exchange at an office or agency maintained pursuant to Section 2.03, the Company shall execute and the Trustee shall authenticate Securities of a like aggregate principal amount at the Registrar’s request. Any
exchange or registration of transfer shall be without charge, except that the Company or the Registrar may require payment of a sum sufficient to cover any tax or other governmental charge that may be imposed in relation thereto; provided
that this sentence shall not apply to any exchange pursuant to Section 2.07, Section 2.10, Section 3.09, Section 4.02(d) or Section 10.05. 

Neither the Company, any Registrar nor the Trustee shall be required to exchange or register a transfer of any Securities or portions thereof
selected for Optional Redemption, in respect of which a Repurchase Exercise Notice pursuant to Section 3.05(c) has been delivered and not validly withdrawn by the Holder thereof or that have been converted (except, in the case of the an
Optional Redemption of a Security in part, purchase of a Security in part, or conversion of a Security in part, the portion thereof not to be redeemed, purchased or converted, as the case may be). 

All Securities issued upon any registration of transfer or exchange of Securities shall be valid obligations of the Company, evidencing the
same debt and entitled to the same benefits under this Indenture, as the Securities surrendered upon such registration of transfer or exchange. The registered Holder of a Security will be treated as its owner for all purposes. The registered Holder
of all Global Securities shall be the Depositary. 
 (b) Any Registrar appointed pursuant to Section 2.03 shall provide to the Trustee
such information as the Trustee may reasonably require in connection with the delivery by such Registrar of Securities upon transfer or exchange of Securities. 

(c) Each Holder agrees to indemnify the Company, each Registrar and the Trustee against any liability that may result from the registration of
transfer, exchange or assignment of such Holder’s Security in violation of any provision of this Indenture and/or applicable United States federal or state securities law. 

(d) Every Security that bears or is required under this Section 2.06(d) to bear the legend set forth in this Section 2.06(d)
(together with any Common Stock issued upon conversion of the Securities that is required to bear the legend set forth in Section 2.06(e), collectively, the “Restricted Securities”) shall be subject to the restrictions on
transfer set forth in this Section 2.06(d) (including the legend set forth below), unless such restrictions on transfer shall be eliminated or otherwise waived by written consent of the Company, and the Holder of each such Restricted Security,
by such Holder’s acceptance thereof, agrees to be bound by all such restrictions on transfer. As used in this Section 2.06(d) and Section 2.06(e), the term “transfer” encompasses any sale, pledge, transfer or other
disposition whatsoever of any Restricted Security. 

  
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 Until the date (the “Resale Restriction Termination Date”) that is the
later of (1) the date that is one year after the last date of original issuance of the Securities, or such shorter period of time as permitted by Rule 144 under the Securities Act or any successor provision thereto, and (2) such later
date, if any, as may be required by applicable law, any certificate evidencing such Security (and all securities issued in exchange therefor or substitution thereof, other than Common Stock, if any, issued upon conversion thereof, which shall bear
the legend set forth in Section 2.06(e), if applicable) shall bear a legend in substantially the following form (unless such Securities have been transferred pursuant to a registration statement that has become or been declared effective under
the Securities Act and that continues to be effective at the time of such transfer, or sold pursuant to the exemption from registration provided by Rule 144 or any similar provision then in force under the Securities Act, or unless otherwise agreed
by the Company in writing, with notice thereof to the Trustee): 
 THIS SECURITY AND THE COMMON STOCK, IF ANY, ISSUABLE UPON CONVERSION OF
THIS SECURITY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND MAY NOT BE OFFERED, SOLD, PLEDGED OR OTHERWISE TRANSFERRED EXCEPT IN ACCORDANCE WITH THE FOLLOWING SENTENCE. BY ITS
ACQUISITION HEREOF OR OF A BENEFICIAL INTEREST HEREIN, THE ACQUIRER: 
 (i) REPRESENTS THAT IT AND ANY ACCOUNT FOR WHICH IT
IS ACTING IS A “QUALIFIED INSTITUTIONAL BUYER” (WITHIN THE MEANING OF RULE 144A UNDER THE SECURITIES ACT) AND THAT IT EXERCISES SOLE INVESTMENT DISCRETION WITH RESPECT TO EACH SUCH ACCOUNT, AND 

(ii) AGREES FOR THE BENEFIT OF AMYRIS, INC. (THE “COMPANY”) THAT IT WILL NOT OFFER, SELL, PLEDGE OR OTHERWISE
TRANSFER THIS SECURITY OR ANY BENEFICIAL INTEREST HEREIN PRIOR TO THE DATE THAT IS THE LATER OF (X) ONE YEAR AFTER THE LAST ORIGINAL ISSUE DATE HEREOF OR SUCH SHORTER PERIOD OF TIME AS PERMITTED BY RULE 144 UNDER THE SECURITIES ACT OR ANY
SUCCESSOR PROVISION THERETO AND (Y) SUCH LATER DATE, IF ANY, AS MAY BE REQUIRED BY APPLICABLE LAW, EXCEPT: 
 (A) TO THE
COMPANY OR ANY SUBSIDIARY OF THE COMPANY, OR 
 (B) PURSUANT TO A REGISTRATION STATEMENT THAT HAS BECOME EFFECTIVE UNDER THE
SECURITIES ACT, OR 
 (C) TO A PERSON THAT IS REASONABLY BELIEVED TO BE A QUALIFIED INSTITUTIONAL BUYER THAT IS PURCHASING
FOR ITS OWN ACCOUNT OR FOR THE ACCOUNT OF ANOTHER QUALIFIED INSTITUTIONAL BUYER AND TO WHOM NOTICE IS GIVEN THAT THE TRANSFER IS BEING MADE IN RELIANCE ON RULE 144A, ALL IN COMPLIANCE WITH RULE 144A (IF AVAILABLE), OR 

  
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 (D) PURSUANT TO AN EXEMPTION FROM REGISTRATION PROVIDED BY RULE 144 UNDER
THE SECURITIES ACT (IF AVAILABLE), OR ANY OTHER AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT. 
 PRIOR TO
THE REGISTRATION OF ANY TRANSFER IN ACCORDANCE WITH CLAUSE (2)(D) ABOVE, THE COMPANY AND THE TRUSTEE RESERVE THE RIGHT TO REQUIRE THE DELIVERY OF SUCH LEGAL OPINIONS, CERTIFICATIONS OR OTHER EVIDENCE AS MAY REASONABLY BE REQUIRED IN ORDER FOR THE
COMPANY TO DETERMINE THAT THE PROPOSED TRANSFER IS BEING MADE IN COMPLIANCE WITH THE SECURITIES ACT AND APPLICABLE STATE SECURITIES LAWS. NO REPRESENTATION IS MADE AS TO THE AVAILABILITY OF ANY EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE
SECURITIES ACT. 
 No transfer of any Security prior to the Resale Restriction Termination Date will be registered by the Security Registrar
unless the applicable box on the Form of Assignment (as set forth as an attachment to the Form of Security set forth in Exhibit A hereto) has been checked. 

Any Security (or security issued in exchange or substitution therefor) as to which such restrictions on transfer shall have expired in
accordance with their terms may, upon surrender of such Security for exchange to the Security Registrar in accordance with the provisions of this Section 2.06(d), be exchanged for a new Security or Securities, of like tenor and aggregate
principal amount, which shall not bear the restrictive legend required by this Section 2.06(d) and shall not be assigned a restricted CUSIP number. The Company shall be entitled to instruct the Securities Custodian in writing to so surrender
any Global Security as to which such restrictions on transfer shall have expired in accordance with their terms for exchange pursuant to the Applicable Procedures, and, upon such instruction, the Securities Custodian shall so surrender such Global
Security for exchange, and any new Global Security so exchanged therefor shall not bear the restrictive legend specified in this Section 2.06(d) and shall not be assigned a restricted CUSIP number. The Company shall promptly notify the Trustee
upon the occurrence of the Resale Restriction Termination Date and promptly after a registration statement, if any, with respect to the Securities or any Common Stock issued upon conversion of the Securities has been declared effective under the
Securities Act. 
 (e) Until the Resale Restriction Termination Date, any stock certificate representing Common Stock issued upon conversion
of such Security shall bear a legend in substantially the following form (unless the Security or such Common Stock has been transferred pursuant to a registration statement that has become or been declared effective under the Securities Act and that
continues to be effective at the time of such transfer, or pursuant to the exemption from registration provided by Rule 144 or any similar provision then in force under the Securities Act, or such Common Stock has been issued upon conversion of
Securities that have been transferred pursuant to a registration statement that has become or been declared effective under the Securities Act and that continues to be effective at the time of such transfer, or pursuant to the exemption from
registration provided by Rule 144 or any similar provision then in force under the Securities Act, or unless otherwise agreed by the Company with written notice thereof to the Trustee and any transfer agent for the Common Stock): 

  
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 THIS SECURITY HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE
“SECURITIES ACT”), AND MAY NOT BE OFFERED, SOLD, PLEDGED OR OTHERWISE TRANSFERRED EXCEPT IN ACCORDANCE WITH THE FOLLOWING SENTENCE. BY ITS ACQUISITION HEREOF OR OF A BENEFICIAL INTEREST HEREIN, THE ACQUIRER: 

(i) REPRESENTS THAT IT AND ANY ACCOUNT FOR WHICH IT IS ACTING IS A “QUALIFIED INSTITUTIONAL BUYER” (WITHIN THE
MEANING OF RULE 144A UNDER THE SECURITIES ACT) AND THAT IT EXERCISES SOLE INVESTMENT DISCRETION WITH RESPECT TO EACH SUCH ACCOUNT, AND 

(ii) AGREES FOR THE BENEFIT OF AMYRIS, INC. (THE “COMPANY”) THAT IT WILL NOT OFFER, SELL, PLEDGE OR OTHERWISE
TRANSFER THIS SECURITY OR ANY BENEFICIAL INTEREST HEREIN PRIOR TO THE DATE THAT IS THE LATER OF (X) ONE YEAR AFTER THE LAST ORIGINAL ISSUE DATE OF THE SERIES OF NOTES UPON THE CONVERSION OF WHICH THIS SECURITY WAS ISSUED OR SUCH SHORTER PERIOD
OF TIME AS PERMITTED BY RULE 144 UNDER THE SECURITIES ACT OR ANY SUCCESSOR PROVISION THERETO AND (Y) SUCH LATER DATE, IF ANY, AS MAY BE REQUIRED BY APPLICABLE LAW, EXCEPT: 

(A) TO THE COMPANY OR ANY SUBSIDIARY OF THE COMPANY, OR 

(B) PURSUANT TO A REGISTRATION STATEMENT THAT HAS BECOME EFFECTIVE UNDER THE SECURITIES ACT, OR 

(C) TO A PERSON THAT IS REASONABLY BELIEVED TO BE A QUALIFIED INSTITUTIONAL BUYER THAT IS PURCHASING FOR ITS OWN ACCOUNT OR FOR
THE ACCOUNT OF ANOTHER QUALIFIED INSTITUTIONAL BUYER AND TO WHOM NOTICE IS GIVEN THAT THE TRANSFER IS BEING MADE IN RELIANCE ON RULE 144A, ALL IN COMPLIANCE WITH RULE 144A (IF AVAILABLE), OR 

(D) PURSUANT TO AN EXEMPTION FROM REGISTRATION PROVIDED BY RULE 144 UNDER THE SECURITIES ACT (IF AVAILABLE) OR ANY OTHER
AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT. 
 PRIOR TO THE REGISTRATION OF ANY TRANSFER IN ACCORDANCE
WITH CLAUSE (2)(D) ABOVE, THE COMPANY AND THE TRANSFER AGENT FOR THE COMPANY’S COMMON STOCK RESERVE THE RIGHT TO REQUIRE THE DELIVERY OF SUCH LEGAL OPINIONS, CERTIFICATIONS OR OTHER EVIDENCE AS MAY REASONABLY BE REQUIRED IN ORDER FOR THE
COMPANY TO DETERMINE THAT THE PROPOSED TRANSFER IS BEING MADE IN COMPLIANCE WITH THE SECURITIES ACT AND APPLICABLE STATE SECURITIES LAWS. NO REPRESENTATION IS MADE AS TO THE AVAILABILITY OF ANY EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE
SECURITIES ACT. 

  
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 Any such Common Stock as to which such restrictions on transfer shall have expired in
accordance with their terms may, upon surrender of the certificates representing such shares of Common Stock for exchange in accordance with the procedures of the transfer agent for the Common Stock, be exchanged for a new certificate or
certificates for a like aggregate number of shares of Common Stock, which shall not bear the restrictive legend required by this Section 2.06(e). 

Any Security or Common Stock issued upon the conversion or exchange of a Security that is repurchased or owned by any Affiliate of the Company
(or any Person who was an Affiliate of the Company at any time during the three months preceding) may not be resold by such Affiliate (or such Person, as the case may be) unless registered under the Securities Act or resold pursuant to an exemption
from the registration requirements of the Securities Act in a transaction that results in such Security or Common Stock, as the case may be, no longer being a “restricted security” (as defined under Rule 144 under the Securities Act). The
Company shall cause any Security that is repurchased or owned by it or any of its Subsidiaries to be surrendered to the Trustee for cancellation in accordance with Section 2.11. 

The Trustee shall have no obligation or duty to monitor, determine or inquire as to compliance with any restrictions on transfer imposed under
this Indenture or under applicable law with respect to any transfer of any interest in any Security (including any transfers between or among Agent Members or other beneficial owners of interests in any Global Security) other than to require
delivery of such certificates and other documentation or evidence as are expressly required by, and to do so if and when expressly required by the terms of, this Indenture, and to examine the same to determine substantial compliance as to form with
the express requirements hereof. 
 Neither the Trustee nor any Agent shall have any responsibility for any actions taken or not taken by
the Depositary. Neither the Trustee nor any Agent shall have any responsibility or obligation to any beneficial owner of an interest in a Global Security, Agent Members or any other Persons with respect to the accuracy of the records of DTC or its
nominee or of Agent Members, with respect to any ownership interest in the Securities or with respect to the delivery to any Agent Member, beneficial owner or other Person (other than DTC) of any notice or the payment of any amount or delivery of
any Securities (or other security or property) under or with respect to such Securities. All notices and communications to be given to the Holders and all payments to be made to Holders in respect of the Securities shall be given or made only to or
upon the order of the registered Holders (which shall be the Depositary or its nominee in the case of a Global Security). The rights of beneficial owners in any Global Security shall be exercised only through the Depositary, subject to the
Applicable Procedures. The Trustee may rely and shall be fully protected in relying upon information furnished by DTC with respect to its Agent Members and any beneficial owners. 

  
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 The Trustee shall have no obligation or duty to monitor, determine or inquire as to
compliance with any restrictions on transfer imposed under this Indenture or under applicable law with respect to any transfer of any interest in any Security (including any transfers between or among Agent Members or beneficial owners in any
Security) other than to require delivery of such certificates and other documentation or evidence as are expressly required by, and to do so if and when expressly required by, the terms of this Indenture, and to examine the same to determine
substantial compliance as to form with the express requirements hereof. 
 Section 2.07. Replacement Securities. If any
mutilated Security is surrendered to the Company, a Registrar or the Trustee, or the Trustee receives evidence to its satisfaction of the destruction, loss or theft of any Security, and there is delivered to the Company, the applicable Registrar and
the Trustee such security or indemnity as will be required by them to save each of them harmless, then, in the absence of notice to the Company, such Registrar or the Trustee that such Security has been acquired by a protected purchaser, the Company
shall execute, and upon its written request the Trustee shall authenticate and deliver, in exchange for any such mutilated Security or in lieu of any such destroyed, lost or stolen Security, a new Security of like tenor and principal amount, bearing
a number not contemporaneously outstanding. 
 In case any such mutilated, destroyed, lost or stolen Security has become or is about to
become due and payable, or is about to be repurchased by the Company pursuant to Article 3, the Company in its discretion may, instead of issuing a new Security, pay or repurchase such Security, as the case may be. 

Upon the issuance of any new Securities under this Section 2.07, the Company may require the payment of a sum sufficient to cover any
tax, assessment or other governmental charge that may be imposed in relation thereto and any other reasonable expenses (including the reasonable fees and expenses of the Trustee or the Registrar) in connection therewith. 

Every new Security issued pursuant to this Section 2.07 in lieu of any mutilated, destroyed, lost or stolen Security shall constitute an
original additional contractual obligation of the Company, whether or not the mutilated, destroyed, lost or stolen Security shall be at any time enforceable by anyone, and shall be entitled to all benefits of (but shall be subject to all the
limitations set forth in) this Indenture equally and proportionately with any and all other Securities duly issued hereunder. 
 The
provisions of this Section 2.07 are (to the extent lawful) exclusive and shall preclude (to the extent lawful) all other rights and remedies with respect to the replacement or payment of mutilated, destroyed, lost or stolen Securities. 

Section 2.08. Outstanding Securities. Securities outstanding at any time are all Securities authenticated by the Trustee, except
for those canceled by it, those redeemed pursuant to Article 3, those converted pursuant to Article 4, those repurchased pursuant to Section 2.11 or Article 3, those delivered to it for cancellation or surrendered for transfer or exchange and
those described in this Section 2.08 as not outstanding. 
 If a Security is replaced pursuant to Section 2.07, it ceases to be
outstanding unless the Trustee receives proof satisfactory to it that the replaced Security is held by a protected purchaser. 

  
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 If a Paying Agent (other than the Company or an Affiliate of the Company) holds by 12:00
p.m., New York City time, on the Maturity Date, any Redemption Date in respect of Securities subject to Optional Redemption or any Fundamental Change Repurchase Date in respect of Securities subject to repurchase upon a Fundamental Change, money
sufficient to pay the principal of and accrued interest on Securities (or portions thereof) payable on that date, then on and after such date such Securities (or portions thereof, as the case may be) shall cease to be outstanding and interest on
them shall cease to accrue. 
 Subject to the restrictions contained in Section 2.09, a Security does not cease to be outstanding
because the Company or an Affiliate of the Company holds the Security. 
 Section 2.09. Treasury Securities. In determining
whether the Holders of the required principal amount of Securities have concurred in any notice, direction, waiver or consent, Securities owned by the Company or any other obligor on the Securities or by any Affiliate of the Company or of such other
obligor shall be disregarded, except that, for purposes of determining whether the Trustee shall be protected in relying on any such notice, direction, waiver or consent, only Securities that a Responsible Officer of the Trustee actually knows are
so owned shall be so disregarded. Securities so owned that have been pledged in good faith shall not be disregarded if the pledgee establishes to the satisfaction of the Trustee the pledgee’s right so to act with respect to the Securities and
that the pledgee is not the Company or any other obligor on the Securities or any Affiliate of the Company or of such other obligor. 

Section 2.10. Temporary Securities. Until definitive Securities are ready for delivery, the Company may prepare and execute, and,
upon receipt of a Company Order, the Trustee shall authenticate and deliver, temporary Securities. Temporary Securities shall be substantially in the form of Certificated Securities but may have variations that the Company considers appropriate for
temporary Securities and as shall be reasonably acceptable to the Trustee. Without unreasonable delay, the Company shall prepare and the Trustee, upon receipt of a Company Order, shall authenticate and deliver definitive Securities in exchange for
temporary Securities. Holders of temporary Securities shall be entitled to all the benefits of and subject to the same limitations under this Indenture as Certificated Securities authenticated and delivered hereunder. 

Section 2.11. Cancellation; Repurchase. The Company shall cause all Securities surrendered for the purpose of payment, purchase
upon a Fundamental Change in accordance with Article 3, repurchase, redemption, registration of transfer or exchange or conversion, if surrendered to any Person other than the Trustee (including any of the Company’s Agents, Subsidiaries or
Affiliates), to be delivered to the Trustee for cancellation. The Registrar, the Paying Agent and the Conversion Agent shall forward to the Trustee or its agent any Securities surrendered to them for registration of transfer, exchange, payment or
conversion. The Company shall instruct the Trustee in writing to cancel all Securities surrendered by it to the Trustee, and upon such instructions the Trustee shall cancel all Securities surrendered to it for the purpose of payment, repurchase,
redemption, registration of transfer, exchange, conversion or cancellation, and the Trustee and no one else shall cancel, in accordance with its customary procedures, all Securities so surrendered and shall dispose of canceled Securities (subject to
the record retention requirements of the Trustee and the Exchange Act), in accordance with its standard procedures, and no Securities shall be authenticated in exchange thereof except as expressly permitted by any of the provisions of this
Indenture. The Company may not hold or resell such Securities or issue new Securities to replace Securities that it has purchased or otherwise acquired or that have been delivered to the Trustee for cancellation. 

  
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 The Company may, to the extent permitted by law, and directly or indirectly (regardless of
whether such Securities are surrendered to the Company), repurchase Securities in the open market, by tender offer or exchange offer, by private agreement through counterparties or otherwise, whether by the Company or its Subsidiaries, including by
cash-settled swaps or other derivatives and, in each case, at any price. The Company shall cause any Securities so repurchased (other than Securities repurchased pursuant to cash-settled swaps or other derivatives that are not physically settled) to
be surrendered to the Trustee for cancellation in accordance with this Section 2.11, and they shall no longer be considered outstanding under this Indenture upon their repurchase. Any Securities held by the Company or one of its Affiliates
shall be disregarded for voting purposes in connection with any notice, waiver, consent or direction requiring the vote or concurrence of Holders. 

Section 2.12. Additional Transfer and Exchange Requirements. (a) A Global Security may not be transferred, in whole or in
part, to any Person other than the Depositary or a nominee or any successor thereof, and no such transfer to any such other Person may be registered; provided that the foregoing shall not prohibit any transfer of a Security that is issued in
exchange for a Global Security but is not itself a Global Security. No transfer of a Security to any Person shall be effective under this Indenture or the Securities unless and until such Security has been registered in the name of such Person.
Notwithstanding any other provisions of this Indenture or the Securities, transfers of a Global Security, in whole or in part, shall be made only in accordance with this Section 2.12. 

(b) The provisions of subsections (i), (ii), (iii), (iv) and (v) below shall apply only to Global Securities: 

(i) Notwithstanding any other provisions of this Indenture or the Securities, a Global Security shall not be exchanged in whole
or in part for a Security registered in the name of any Person other than the Depositary or one or more nominees thereof; provided that a Global Security may be exchanged for Certificated Securities registered in the names of any Person
designated by the Depositary in the event that (A) the Depositary has notified the Company that it is unwilling or unable to continue as Depositary for such Global Security or the Depositary has ceased to be a “clearing agency”
registered under the Exchange Act, and a successor Depositary is not appointed by the Company within 90 days or (B) an Event of Default has occurred and is continuing and a beneficial owner requests through DTC that its Securities be exchanged
for Certificated Securities. Any Global Security exchanged pursuant to clause (A) above shall be so exchanged in whole and not in part, and any Global Security exchanged pursuant to clause (B) above may be exchanged in whole or from time
to time in part as directed by the Depositary. Any Security issued in exchange for a Global Security or any portion thereof shall be a Global Security; provided that any such Security so issued that is registered in the name of a Person other
than the Depositary or a nominee thereof shall not be a Global Security. 
 (ii) Securities issued in exchange for a Global
Security or any portion thereof shall be issued in fully registered book-entry form, without interest coupons, shall have an aggregate principal amount equal to that of such Global Security or portion thereof to be so exchanged, shall be registered
in such names and be in such authorized denominations as the Depositary shall designate and shall bear any applicable legend 

  
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provided for herein. Any Global Security to be exchanged in whole shall be surrendered by the Depositary to the Trustee, as Registrar. With regard to any Global Security to be exchanged in part,
either such Global Security shall be so surrendered for exchange or, if the Trustee is acting as Securities Custodian for the Depositary or its nominee with respect to such Global Security, the principal amount thereof shall be reduced, by an amount
equal to the portion thereof to be so exchanged, by means of an appropriate adjustment made on the records of the Trustee. Upon any such surrender or adjustment, the Trustee shall authenticate and deliver the Security issuable on such exchange to or
upon the order of the Depositary or an authorized representative thereof; provided, however, that any Global Security surrendered for exchange shall be duly endorsed or accompanied by a written instrument of transfer in accordance with
the proviso to the first sentence of the first paragraph of Section 2.06(a). 
 (iii) Subject to the provisions
of subsection (v) below, the registered Holder may grant proxies and otherwise authorize any Person, including Agent Members and Persons that may hold interests through Agent Members, to take any action which a Holder is entitled to take under
this Indenture or the Securities. 
 (iv) In the event of the occurrence of any of the events specified in subsection
(i) above, the Company will promptly make available to the Trustee a reasonable supply of Certificated Securities in definitive, fully registered form, without interest coupons. 

(v) Except as specifically provided in this Indenture, neither Agent Members nor any other Persons on whose behalf Agent
Members may act shall have any rights under this Indenture with respect to any Global Security registered in the name of the Depositary or any nominee thereof, or under any such Global Security, and the Depositary or such nominee, as the case may
be, may be treated by the Company, the Trustee and any agent of the Company or the Trustee as the absolute owner and Holder of such Global Security for all purposes whatsoever. Notwithstanding the foregoing, nothing herein shall prevent the Company,
the Trustee or any agent of the Company or the Trustee from giving effect to any written certification, proxy or other authorization furnished by the Depositary or such nominee, as the case may be, or impair, as between the Depositary, its Agent
Members and any other Person on whose behalf an Agent Member may act, the operation of customary practices of such Persons governing the exercise of the rights of a Holder of any Security. 

(c) In the event that Certificated Securities are issued in exchange for beneficial interests in Global Securities and, thereafter, the events
or conditions specified in Section 2.12(b)(i) that required such exchange shall cease to exist, the Company shall deliver notice to the Trustee and to the Holders stating that Holders may exchange Certificated Securities for interests in Global
Securities by complying with the procedures set forth in this Indenture and briefly describing such procedures and the events or circumstances requiring that such notice be given. Thereafter, if Certificated Securities are presented by a Holder to a
Registrar with a request: 
 (i) to register the transfer of such Certificated Securities to a Person who will take delivery
thereof in the form of a beneficial interest in a Global Security; or 

  
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 (ii) to exchange such Certificated Securities for an equal principal amount
of beneficial interests in a Global Security, which beneficial interests will be owned by the Holder transferring such Certificated Securities, 
 the
Registrar shall register the transfer or make the exchange as requested by canceling such Certificated Securities and causing, or directing the Securities Custodian to cause, the aggregate principal amount of the applicable Global Security to be
increased accordingly and, if no such Global Security is then outstanding, the Company shall issue and the Trustee, upon receipt of a Company Order, shall authenticate and deliver a new Global Security; provided, however, that the
Certificated Securities presented or surrendered for registration of transfer or exchange shall be duly endorsed or accompanied by a written instrument of transfer in accordance with the proviso to the first sentence of the first paragraph of
Section 2.06(a). 
 Section 2.13. CUSIP Numbers. The Company in issuing the Securities may use one or more
“CUSIP” numbers (if then generally in use), and, if so, the Trustee shall use “CUSIP” numbers in notices as a convenience to Holders; provided that any such notice may state that no representation is made as to the
correctness of such numbers either as printed on the Securities or as contained in any notice and that reliance may be placed only on the other identification numbers printed on the Securities, and any such notice or related action by the Company
contemplated thereby shall not be affected by any defect in or omission of such numbers. The Company will promptly notify the Trustee in writing of any change in the “CUSIP” numbers. 

ARTICLE 3 
 OPTIONAL
REDEMPTION; REPURCHASE UPON A FUNDAMENTAL CHANGE 
 Section 3.01. Optional Redemption. No sinking fund is provided for the
Securities. The Securities shall not be redeemable by the Company prior to November 20, 2024. On or after November 20, 2024, Company may redeem (an “Optional Redemption”) for cash all or any portion of the Securities
(subject to the Partial Redemption Limitation), at the Redemption Price, if the Last Reported Sale Price of the Common Stock has been at least 130% of the Conversion Price then in effect for at least 20 Trading Days (whether or not consecutive)
during any 30 consecutive Trading Day period (including the last Trading Day of such period) ending on, and including, the Trading Day immediately preceding the date on which the Company provides the Redemption Notice in accordance with
Section 3.02. 
 Section 3.02. Notice of Optional Redemption; Selection of Securities. (a) In case the Company
exercises its Optional Redemption right to redeem all or, as the case may be, any part of the Securities pursuant to Section 3.01, it shall fix a date for redemption (each, a “Redemption Date”) and it or, at its written request
together with the Redemption Notice to be given, an Officers’ Certificate and an Opinion of Counsel received by the Trustee not less than 55 Scheduled Trading Days prior to the Redemption Date (or such shorter period of time as may be
acceptable to the Trustee), the Trustee, in the name of and at the expense of the Company, shall deliver or cause to be delivered a notice of such Optional Redemption (a “Redemption Notice”) not less than 50 nor more than 65
Scheduled Trading Days prior to the Redemption Date to each Holder of Securities so to be redeemed as a whole or in part; provided, however, that, if the Company is then otherwise permitted to settle conversions of Securities by
Physical 

  
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Settlement (and, for the avoidance of doubt, has not irrevocably elected another Settlement Method), and the Company elects to settle all conversions of Called Securities with a Conversion Date
that occurs during the related Redemption Period by Physical Settlement, then the Company may instead elect to choose a Redemption Date that is a Business Day not less than 15 nor more than 50 Scheduled Trading Days after the date the Company sends
such Redemption Notice. If the Company shall give such notice, it shall also give a copy of the Redemption Notice to the Trustee and the Paying Agent (if other than the Trustee). The Redemption Date must be a Business Day, and the Company shall not
specify a Redemption Date that falls on or after the 45th Scheduled Trading Day immediately preceding the Maturity Date. 
 (b) The
Redemption Notice, if delivered in the manner herein provided, shall be conclusively presumed to have been duly given, whether or not the Holder receives such notice. In any case, failure to give such Redemption Notice by mail or any defect in the
Redemption Notice to the Holder of any Security designated for redemption as a whole or in part shall not affect the validity of the proceedings for the redemption of any other Security. 

(c) Each Redemption Notice shall specify: 

(i) the Redemption Date; 

(ii) the Redemption Price; 

(iii) that on the Redemption Date, the Redemption Price will become due and payable upon each Security to be redeemed, and that
interest thereon, if any, shall cease to accrue on and after the Redemption Date; 
 (iv) the place or places where such
Securities are to be surrendered for payment of the Redemption Price; 
 (v) that Holders of Called Securities may surrender
such Securities for conversion on account of such Optional Redemption at any time prior to the close of business on the Scheduled Trading Day immediately preceding the Redemption Date; 

(vi) the procedures a converting Holder must follow to convert its Securities and the Settlement Method and Specified Dollar
Amount, if applicable; 
 (vii) the Conversion Rate and, if applicable, the number of Additional Shares added to the
Conversion Rate in accordance with Section 4.04; 
 (viii) the CUSIP, ISIN or other similar numbers, if any, assigned to
such Securities; and 
 (ix) in case any Security is to be redeemed in part only, the portion of the principal amount thereof
to be redeemed and on and after the Redemption Date, upon surrender of such Security, a new Security in principal amount equal to the unredeemed portion thereof shall be issued. 

  
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 A Redemption Notice shall be irrevocable. 

(d) If fewer than all of the outstanding Securities are to be redeemed, at least $100.0 million aggregate principal amount of Securities
must be outstanding and not subject to Optional Redemption as of the relevant Redemption Date (such requirement, the “Partial Redemption Limitation”). If fewer than all of the outstanding Securities are to be redeemed, and the
Securities are Global Securities, the Securities to be redeemed will be selected by the Depositary in accordance with the Applicable Procedures. If fewer than all of the outstanding Securities are to be redeemed, and the Securities to be redeemed
are not Global Securities, the Trustee shall select the Securities or portions thereof of a Global Security or the Securities in certificated form to be redeemed (in principal amounts of $1,000 or multiples thereof) by lot, on a pro rata
basis or by another method the Trustee considers to be fair and appropriate. If any Security selected for partial redemption is submitted for conversion in part after such selection, the portion of the Security submitted for conversion shall be
deemed (so far as may be possible) to be the portion selected for redemption, subject to the Applicable Procedures. 
 Section 3.03.
Payment of Securities Called for Redemption. (a) If any Redemption Notice has been given in respect of all or any part of the Securities in accordance with Section 3.02, the Securities subject to such Redemption Notice shall become
due and payable on the Redemption Date at the place or places stated in the Redemption Notice and at the applicable Redemption Price, and such Securities shall be paid and redeemed by the Company at the applicable Redemption Price. 

(b) Prior to 12:00 p.m., New York City time, on the Redemption Date, the Company shall deposit with the Paying Agent or, if the Company or a
Subsidiary of the Company is acting as the Paying Agent, shall segregate and hold in trust an amount of cash (in immediately available funds if deposited on the Redemption Date), sufficient to pay the Redemption Price of all of the Securities to be
redeemed on such Redemption Date. Subject to receipt of funds by the Paying Agent, payment for the Securities to be redeemed shall be made on the Redemption Date for such Securities. The Paying Agent shall, promptly after such payment and upon
written demand by the Company, return to the Company any funds in excess of the Redemption Price. 
 Section 3.04. Restrictions on
Redemption. The Company may not redeem any Securities on any date if the principal amount of the Securities has been accelerated in accordance with the terms of this Indenture, and such acceleration has not been rescinded, on or prior to the
Redemption Date (except in the case of an acceleration resulting from a Default by the Company in the payment of the Redemption Price with respect to such Securities). 

Section 3.05. Repurchase at Option of the Holder upon a Fundamental Change. (a) Subject to the satisfaction of the
requirements of this Article 3, if a Fundamental Change occurs at any time prior to the Maturity Date, each Holder shall have the right, at its option, to require the Company to repurchase for cash all of their Securities, or any portion of the
principal thereof that is equal to $1,000 or an integral multiple of $1,000 at a repurchase price (the “Fundamental Change Repurchase Price”) equal to 100% of the principal amount of the Securities to be repurchased, plus accrued
and unpaid interest, if any, to, but excluding, the Fundamental Change Repurchase Date (unless such Fundamental Change Repurchase Date falls after a Regular Record Date and on or prior to the corresponding Interest Payment Date, in which case the
Company shall pay the full amount of accrued and unpaid interest payable on such Interest Payment Date to the Holder of record at the close of business on such Regular Record Date and the Fundamental Change Repurchase Price shall be equal to 100% of
the principal amount of the Securities to be repurchased). 

  
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 (b) On or before the tenth Business Day after the date on which a Fundamental Change becomes
effective, the Company shall provide to all Holders of the Securities, the Trustee and the Conversion Agent (if other than the Trustee) a written notice of the occurrence of the Fundamental Change and of the resulting repurchase right (the
“Fundamental Change Repurchase Right Notice”). The Fundamental Change Repurchase Right Notice shall state: 

(i) the event or events giving rise to the Fundamental Change; 

(ii) if the Fundamental Change also constitutes a Make-Whole Fundamental Change; 

(iii) if applicable, the Conversion Rate and any adjustments to the Conversion Rate; 

(iv) the effective date of the Fundamental Change; 

(v) the last date on which a Holder may exercise the repurchase right; 

(vi) the Fundamental Change Repurchase Price; 

(vii) the Fundamental Change Repurchase Date; 

(viii) the name and address of the Paying Agent and the Conversion Agent; 

(ix) that the Securities with respect to which a Repurchase Exercise Notice has been given by the Holder may be converted only
if the Holder withdraws the Repurchase Exercise Notice as described in Section 3.05(d); and 
 (x) the procedures that
Holders must follow to require the Company to repurchase their Securities. 
 Simultaneously with providing the Fundamental Change
Repurchase Right Notice, the Company shall publish the information on the Company’s website or through a public medium the Company may use at that time. 

(c) To exercise the repurchase right in connection with a Fundamental Change, a Holder must deliver, prior to the close of business on the
Business Day immediately preceding the Fundamental Change Repurchase Date, the Securities to be purchased to the Paying Agent, duly endorsed for transfer, or effect book-entry transfer of the Securities to the Paying Agent, together with a written
notice exercising its right to require the Company to repurchase its Securities or a portion thereof (a “Repurchase Exercise Notice”), substantially in the form included in Exhibit A hereto, duly completed, to the Paying Agent. The
Repurchase Exercise Notice must state: 
 (i) if the Securities are Certificated Securities, the certificate numbers of the
Securities to be delivered for repurchase; 

  
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 (ii) the portion of the principal amount of the Securities to be
repurchased, which must be equal to $1,000 or an integral multiple thereof; and 
 (iii) that the Securities are to be
repurchased by the Company as of the Fundamental Change Repurchase Date pursuant to the applicable provisions of the Securities and this Indenture. 

If the Securities are Global Securities, the Repurchase Exercise Notice must comply with the Applicable Procedures. 

A Holder may withdraw any Repurchase Exercise Notice (in whole or in part) by a written notice of withdrawal delivered to the Paying Agent
prior to the close of business on the Business Day prior to the Fundamental Change Repurchase Date. The notice of withdrawal must state: 

(i) the principal amount of the Securities for which the Repurchase Exercise Notice has been withdrawn; 

(ii) if Certificated Securities have been issued, the certificate numbers of the withdrawn Securities; and 

(iii) the principal amount, if any, that remains subject to the Repurchase Exercise Notice. 

If the Securities are Global Securities, the withdrawal notice must comply with the Applicable Procedures. 

(d) The Company must repurchase the Securities on a date (the “Fundamental Change Repurchase Date”) chosen by the Company that
is no less than 20 and no more than 35 Business Days after the date of the Fundamental Change Repurchase Right Notice with respect to the occurrence of the relevant Fundamental Change. To receive payment of the Fundamental Change Repurchase Price, a
Holder must either effect book-entry transfer or deliver the Securities, together with necessary endorsements, to the office of the Paying Agent after delivery of the Repurchase Exercise Notice. Holders shall receive payment of the Fundamental
Change Repurchase Price on the later of (i) the Fundamental Change Repurchase Date and (ii) the time of book-entry transfer or the delivery of the Securities. If the Paying Agent holds by 11:00 a.m. New York City time money deposited by
the Company sufficient to pay the Fundamental Change Repurchase Price of the Securities on the Fundamental Change Repurchase Date, then with respect to the Securities that have been properly surrendered for repurchase and have not been validly
withdrawn: 
 (i) the Securities will cease to be outstanding and interest, if any, will cease to accrue (whether or not
book-entry transfer of the Securities is made or whether or not the Securities are delivered to the Paying Agent); and 

  
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 (ii) all other rights of the Holder of such Securities will terminate (other
than the right to receive the Fundamental Change Repurchase Price upon delivery or transfer of the Securities). 
 Section 3.06.
Compliance with Securities Laws upon Purchase of Securities. In connection with any offer to purchase the Securities under Section 3.05, the Company shall comply with all tender offer rules applicable to the Company under the Exchange
Act. The Company shall (a) comply with the provisions of Rule 13e-4, Rule 14e-1 (or any successor to either such Rule) and any other tender offer rules, if
applicable, under the Exchange Act, (b) file a Schedule TO (or any successor or similar schedule, form or report), if required, under the Exchange Act and (c) otherwise comply with all federal and state securities laws in connection with
such offer by the Company to purchase the Securities upon a Fundamental Change, so as to permit the rights of the Holders and obligations of the Company under Section 3.05 to be exercised in the time and in the manner specified therein. 

Section 3.07. No Repurchase upon Acceleration. No Securities may be repurchased on any date at the option of Holders upon a
Fundamental Change if the principal amount of the Securities has been accelerated, and such acceleration has not been rescinded, on or prior to such date (except in the case of an acceleration resulting from a Default by the Company in the payment
of the Fundamental Change Repurchase Price with respect to such Securities). The Paying Agent will promptly return to the respective Holders thereof any Certificated Securities held by it following the acceleration of the Securities (except in the
case of an acceleration resulting from a Default by the Company in the payment of the Fundamental Change Repurchase Price with respect to such Securities), and any instructions for book-entry transfer of the Securities in compliance with the
procedures of the Depositary shall be deemed to have been cancelled, and, upon such return or cancellation, as the case may be, the Fundamental Change Repurchase Notice with respect thereto shall be deemed to have been withdrawn. 

Section 3.08. Repayment to the Company. To the extent that the aggregate amount of cash deposited by the Company pursuant to
Section 3.05 exceeds the aggregate Fundamental Change Repurchase Price of the Securities or portions thereof that the Company is obligated to purchase, then promptly after the Fundamental Change Repurchase Date, the Trustee or a Paying Agent,
as the case may be, shall return any such excess cash to the Company. 
 Section 3.09. Partial Redemption or Repurchase. Upon
surrender of a Security that is to be redeemed in part pursuant to Section 3.01 or repurchased in part pursuant to Section 3.05, the Company shall execute and the Trustee shall authenticate and deliver (or transfer by book entry) to the
Holder a new Security in an authorized denomination equal in principal amount to the redeemed or unrepurchased, as applicable, portion of the Security surrendered. 

  
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 ARTICLE 4 

CONVERSION 

Section 4.01. Conversion Rights. (a) Subject to and upon compliance with the provisions of this Article 4, each Holder of a
Security shall have the right, at such Holder’s option, to convert all or any portion (if the portion to be converted is $1,000 principal amount or an integral multiple thereof) of such Security (i) subject to satisfaction of one or more
of the conditions described in subsections (b) through (f) of this Section 4.01, at any time prior to the close of business on the Business Day immediately preceding June 15, 2026 under the circumstances and during the periods set
forth in subsections (b) through (f) of this Section 4.01, and (ii) irrespective of the conditions set forth in subsections (b) through (f) of this Section 4.01, on or after June 15, 2026 and prior to the close of
business on the second Scheduled Trading Day immediately preceding the Maturity Date, in each case at an initial conversion rate of 93.0579 shares of Common Stock (subject to adjustment as provided in this Article 4, the “Conversion
Rate”) per $1,000 principal amount of Securities (subject to the settlement provisions of Section 4.02, the “Conversion Obligation”). 

(b) Prior to the close of business on the Business Day immediately preceding June 15, 2026, a Holder may surrender all or any portion of
its Securities for conversion during any calendar quarter commencing after the calendar quarter ending on December 31, 2021 (and only during such calendar quarter), if the Last Reported Sale Price of the Common Stock for at least 20 Trading
Days (whether or not consecutive) during the period of 30 consecutive Trading Days ending on the last Trading Day of the immediately preceding calendar quarter is greater than or equal to 130% of the Conversion Price on each applicable Trading Day.
Neither the Trustee nor any Agent shall have any obligation to make any calculation or to determine whether the Securities may be surrendered for conversion, or to notify the Company, the Depositary, DTC or any of the Holders of the Securities if
the Securities have become convertible. 
 (c) Prior to the close of business on the Business Day immediately preceding June 15, 2026, a
Holder of the Securities may surrender all or any portion of its Securities for conversion during the five Business Day period after any five consecutive Trading Day period (the “Measurement Period”) in which the Trading Price per
$1,000 principal amount of the Securities, as determined following a request by a Holder of the Securities in accordance with the procedures described below, for each Trading Day of the Measurement Period was less than 98% of the product of the Last
Reported Sale Price of Common Stock and the Conversion Rate on each such Trading Day. The Bid Solicitation Agent (if other than the Company) shall have no obligation to determine the Trading Price of the Securities unless the Company has requested
such determination in writing, and the Company shall have no obligation to make such request (or, if the Company is acting as Bid Solicitation Agent, it shall have no obligation to determine the Trading Price) unless a Holder or Holders of at least
$2.0 million in aggregate principal amount of the Securities request(s) in writing that the Company make such a determination and provides the Company with reasonable evidence that the Trading Price per $1,000 principal amount of the Securities
would be less than 98% of the product of the Last Reported Sale Price of Common Stock and the Conversion Rate. At such time, the Company shall instruct the Bid Solicitation Agent (if other than the Company) to determine (and such Bid Solicitation
Agent shall provide such determination to the Company), or if the Company is acting as Bid Solicitation Agent, the Company shall determine, the Trading Price per $1,000 principal amount of Securities beginning on the next Trading Day and on each
successive Trading Day until the Trading Price per $1,000 principal amount of Securities is greater than or equal to 98% of the product of the Last Reported Sale Price of Common Stock and the Conversion Rate. If the Company determines that the
trading price condition set forth in this clause (c) has been met, the Company shall notify the Holders, the Trustee and the Conversion Agent (if other than the Trustee) in writing. If, at any time after the trading price condition set forth in
this clause (c) has 

  
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been met, the Trading Price per $1,000 principal amount of Securities is greater than or equal to 98% of the product of the Last Reported Sale Price of Common Stock and the Conversion Rate for
such date, the Company shall notify the Holders, the Trustee and the Conversion Agent (if other than the Trustee) in writing. If (i) the Company is not acting as the Bid Solicitation Agent, and the Company does not, when it is required to do
so, instruct the Bid Solicitation Agent to obtain bids, or if the Company gives such instruction to the Bid Solicitation Agent and the Bid Solicitation Agent fails to make such determination; or (ii) the Company is acting as Bid Solicitation
Agent and it fails to make such determination, then, in either case, the Trading Price per $1,000 principal amount of Securities will be deemed to be less than 98% of the product of the Last Reported Sale Price of Common Stock and the Conversion
Rate for each Trading Day on which such failure occurs. 
 (d) If the Company calls any Security for Optional Redemption pursuant to
Section 3.01, then the Holder of a Called Security in respect of the relevant Redemption Notice may surrender such Security for conversion at any time prior to the close of business on the Scheduled Trading Day prior to the Redemption Date,
even if such Security is not otherwise convertible at such time. After that time, the right to convert such Called Security on account of the Company’s delivery of such Redemption Notice shall expire, unless the Company defaults in the payment
of the Redemption Price, in which case a Holder of such Called Security may convert such Security (or a portion thereof) until the Redemption Price has been paid or duly provided for. If the Company elects to redeem fewer than all of the outstanding
Securities and the Holder of any Security (or any owner of a beneficial interest in any Global Security) is reasonably not able to determine, before the close of business on the 49th Scheduled Trading Day immediately before the relevant Redemption
Date (or if, as permitted pursuant to Section 3.02(a), the Company delivers a Redemption Notice not less than 15 nor more than 50 Scheduled Trading Days prior to the related Redemption Date with an election to settle all conversions of Called
Securities in respect of the related Redemption Period by Physical Settlement, then prior to close of business on the 14th Scheduled Trading Day immediately before the relevant Redemption Date), whether such Security or beneficial interest, as
applicable, is to be redeemed pursuant to such Optional Redemption, then such Holder or owner, as applicable, shall be entitled to convert such Security or beneficial interest, as applicable, at any time during the related Redemption Period, and
each such conversion shall be deemed to be of a Security called for Optional Redemption (a “Deemed Redemption”). The Trustee shall not be obligated to make any determination in connection with the foregoing sentence. 

(e) If, prior to the close of business on the Business Day immediately preceding June 15, 2026, the Company elects to: 

(i) issue to all or substantially all holders of Common Stock any rights, options or warrants (other than pursuant to a
stockholder rights plan in connection with the initial adoption by the Company, so long as such rights have not separated from the Common Stock) entitling them, for a period of not more than 60 calendar days after the announcement date of such
issuance, to subscribe for or purchase shares of Common Stock at a price per share that is less than the average of the Last Reported Sale Prices of the Common Stock for the ten consecutive Trading Day period ending on, and including, the Trading
Day immediately preceding the date of announcement of such issuance; or 

  
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 (ii) distribute to all or substantially all holders of Common Stock the
Company’s assets, securities or rights to purchase the Company’s securities, which distribution has a per share value, as reasonably determined by the Board of Directors, exceeding 10% of the Last Reported Sale Price of the Common Stock on
the Trading Day preceding the date of announcement of such distribution, 
 then, in either case, the Company shall notify the Holders of the Securities
(with a copy of such notice to the Trustee and the Conversion Agent (if other than the Trustee)) in writing at least 50 Scheduled Trading Days prior to the Ex-Dividend Date for such issuance or distribution;
provided, however, that if the Company is then otherwise permitted to settle conversions of Securities by Physical Settlement (and, for the avoidance of doubt, have not irrevocably elected another Settlement Method), then the Company
may instead elect to provide such notice at least ten Scheduled Trading Days prior to such Ex-Dividend Date, in which case the Company shall be required to settle all conversions of Securities with a
Conversion Date occurring during the period on or after the date the Company provides such notice and before such Ex-Dividend Date (or, if earlier, the date the Company announces that such issuance or
distribution will not take place) by Physical Settlement, and the Company shall describe the same in such notice. Once the Company has given such notice, Holders may surrender all or any portion of their Securities for conversion at any time until
the earlier of (a) the close of business on the Business Day immediately preceding the Ex-Dividend Date for such issuance or distribution and (b) the Company’s announcement that such issuance or
distribution will not take place, even if the Securities are not otherwise convertible at such time. No Holder may convert any of its Securities pursuant to the conditions set forth in this Section 4.01(e) if such Holder otherwise participates
in such issuance or distribution, at the same time and upon the same terms as holders of Common Stock and as a result of holding the Securities, without having to convert their Securities, as if they held a number of shares of Common Stock equal to
the applicable Conversion Rate, multiplied by the principal amount (expressed in thousands) of Securities held by such Holder. 
 (f)
If a transaction or event that constitutes a Fundamental Change or Make-Whole Fundamental Change occurs prior to the close of business on the Business Day immediately preceding June 15, 2026, regardless of whether a Holder of the Securities has
the right to require the Company to repurchase the Securities pursuant to Section 3.05, or if the Company is a party to a consolidation, merger, binding share exchange, or transfer or lease of all or substantially all of the Company’s
assets that occurs prior to the close of business on the Business Day immediately preceding June 15, 2026, in each case, pursuant to which Common Stock would be converted into cash, securities or other assets, then all or any portion of a
Holder’s Securities may be surrendered for conversion at any time from or after the effective date of the transaction (or, if later, the Business Day after the Company gives notice of such transaction) until 35 Trading Days after the effective
date of such transaction or, if such transaction also constitutes a Fundamental Change, until the related Fundamental Change Repurchase Date. The Company shall notify the Holders, the Trustee and the Conversion Agent (if other than the Trustee) in
writing (i) at least 10 Scheduled Trading Days prior to the anticipated effective date of such transaction or (ii) if the Company has not publicly announced such transaction at least 10 Scheduled Trading Days prior to the anticipated
effective date of such transaction, then within one Business Day of the day the Company publicly announces such transaction, and in no event later than the actual effective date of such transaction. 

  
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 (g) On or after June 15, 2026, a Holder may convert all or any portion of its
Securities at any time prior to the close of business on the second Scheduled Trading Day immediately preceding the Maturity Date. 

Section 4.02. Settlement upon Conversion; Conversion Procedures. (a) Subject to this Section 4.02, Section 4.04 and
Section 4.07, upon conversion of any Security, the Company shall pay or deliver, as the case may be, to the converting Holder, in respect of each $1,000 principal amount of Securities being converted, cash (“Cash Settlement”),
shares of Common Stock, together with cash, if applicable, in lieu of any fractional share of Common Stock in accordance with subsection (i) of this Section 4.02 (“Physical Settlement”) or a combination of cash and shares
of Common Stock, together with cash, if applicable, in lieu of any fractional share of Common Stock in accordance with subsection (i) of this Section 4.02 (“Combination Settlement”), at its election, as set forth in this
Section 4.02. 
 (i) (A) All conversions of Called Securities for which the relevant Conversion Date occurs during
the related Redemption Period, and all conversions for which the relevant Conversion Date occurs on or after June 15, 2026, shall be settled using the same Settlement Method. Except for any such conversions of Called Securities for which the
relevant Conversion Date occurs during a Redemption Period, and any conversions for which the relevant Conversion Date occurs on or after June 15, 2026, and any conversions following our delivery of an irrevocable Settlement Notice as described
in Section 4.01(e) or Section 4.02(a)(i)(B), the Company shall use the same Settlement Method for all conversions occurring on the same Conversion Date, but the Company shall not have any obligation to use the same Settlement Method with
respect to conversions with different Conversion Dates. If, in respect of any Conversion Date (or one of the periods described in the third immediately succeeding set of parentheses, as the case may be), the Company elects to deliver a notice (the
“Settlement Notice”) of the relevant Settlement Method in respect of such Conversion Date (or such period, as the case may be), the Company shall deliver such Settlement Notice to converting Holders no later than the close of
business on the Trading Day immediately following the relevant Conversion Date (or, in the case of (x) any conversions of Called Securities for which the relevant Conversion Date occurs during the related Redemption Period, in the related
Redemption Notice, or (y) any conversions of Securities for which the relevant Conversion Date occurs on or after June 15, 2026, no later than June 15, 2026). If the Company does not elect a Settlement Method prior to the deadline set
forth in the immediately preceding sentence, the Company shall no longer have the right to elect Cash Settlement or Physical Settlement with respect to such Securities and the Company shall be deemed to have elected Combination Settlement in respect
of its Conversion Obligation, and the Specified Dollar Amount per $1,000 principal amount of Securities shall be deemed to be $1,000. Such Settlement Notice shall be prepared by the Company and shall specify the relevant Settlement Method and, in
the case of an election of Combination Settlement, the relevant Settlement Notice shall indicate the Specified Dollar Amount. If the Company elects Combination Settlement but does not timely notify converting Holders of the Specified Dollar Amount
per $1,000 principal amount of Securities, such Specified Dollar Amount will be deemed to be $1,000. The Company shall separately provide to the Trustee and the Conversion Agent (if other than the Trustee) in writing any notice contemplated by this
clause (A). 

  
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 (B) By notice to Holders of the Securities, the Company may, prior to
June 15, 2026, at the Company’s option, irrevocably elect to satisfy its Conversion Obligation with respect to the Securities through any Settlement Method that the Company is then permitted to elect for all Conversion Dates occurring
subsequent to delivery of such notice. Notwithstanding the foregoing, no such irrevocable election will affect any Settlement Method theretofore elected (or deemed to be elected) with respect to any Security pursuant to this Section 4.02. For
the avoidance of doubt, such an irrevocable election, if made, will be effective without the need to amend this Indenture or the Securities, including pursuant to Section 10.01(f). However, the Company may nonetheless choose to execute such an
amendment at its option. If the Company irrevocably fixes the Settlement Method pursuant to this Section 4.02(a)(i)(B), then the Company shall simultaneously provide written notice to the Trustee and the Conversion Agent (if other than the
Trustee) and either post the fixed Settlement Method on the Company’s website or disclose the same in a current report on Form 8-K (or any successor form) that is filed with the Commission. 

(ii) With respect to any conversion of Securities, the cash, shares of Common Stock or combination of cash and shares of Common
Stock in respect of such conversion (the “Settlement Amount”) shall be computed as follows: 
 (A) if the
Company elects to satisfy its Conversion Obligation in respect of such conversion by Physical Settlement, the Company shall deliver to the converting Holder in respect of each $1,000 principal amount of Securities being converted a number of shares
of Common Stock equal to the Conversion Rate on the Conversion Date; 
 (B) if the Company elects to satisfy its Conversion
Obligation in respect of such conversion by Cash Settlement, the Company shall pay to the converting Holder in respect of each $1,000 principal amount of Securities being converted cash in an amount equal to the sum of the Daily Conversion Values
for each of the 40 consecutive Trading Days during the related Observation Period; and 
 (C) if the Company elects (or is
deemed to have elected) to satisfy its Conversion Obligation in respect of such conversion by Combination Settlement, the Company shall pay or deliver, as the case may be, in respect of each $1,000 principal amount of Securities being converted, a
Settlement Amount equal to the sum of the Daily Settlement Amounts for each of the 40 consecutive Trading Days during the related Observation Period. 

(iii) The Daily Settlement Amounts (if applicable) and the Daily Conversion Values (if applicable) shall be determined by the
Company promptly following the last day of the Observation Period. Promptly after such determination of the Daily Settlement Amounts or the Daily Conversion Values, as the case may be, and the amount of cash payable in lieu of any fractional share,
the Company shall notify the Trustee and the Conversion Agent (if other than the Trustee) of the Daily Settlement Amounts or the Daily Conversion Values, as the case may be, and the amount of cash payable in lieu of fractional shares of Common
Stock. 

  
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 (b) Subject to Section 4.02(e), before any Holder of a Security shall be entitled to
convert a Security as set forth above, such Holder shall (i) in the case of a Certificated Security (or if required by the Applicable Procedures in effect at that time in the case of a Global Security) (A) complete and deliver an
irrevocable notice to the Conversion Agent as set forth in the Form of Conversion Notice attached to the Form of Security set forth in Exhibit A hereto (a “Conversion Notice”) at the office of the Conversion Agent and state in
writing therein the principal amount of Securities to be converted and the name or names (with addresses) in which such Holder wishes the certificate or certificates for any shares of Common Stock to be delivered by the Company or its agent upon
settlement of the Conversion Obligation to be registered, (B) deliver such Security, duly endorsed to the Company or in blank (and accompanied by appropriate endorsement and transfer documents), to the Conversion Agent and (C) if required,
pay funds equal to interest payable on the next Interest Payment Date to which such Holder is not entitled as set forth in subsection (g) of this Section 4.02 and (ii) subject to clause (i), in the case of a Global Security, comply
with the Depositary’s procedures for converting a beneficial interest in a Global Security and, if required, pay funds equal to interest payable on the next Interest Payment Date to which such Holder is not entitled as set forth in subsection
(g) of this Section 4.02. The Trustee (and, if different, the Conversion Agent) shall notify the Company of any conversion pursuant to this Article 4 on the Conversion Date for such conversion. No Conversion Notice with respect to any
Securities may be surrendered by a Holder thereof if such Holder has also delivered a Fundamental Change Repurchase Notice to the Company in respect of such Securities and not validly withdrawn such Fundamental Change Repurchase Notice in accordance
with Section 3.05(c). 
 If more than one Security shall be surrendered for conversion at one time by the same Holder, the Conversion
Obligation with respect to such Securities shall be computed on the basis of the aggregate principal amount of the Securities (or specified portions thereof to the extent permitted thereby) so surrendered. 

(c) A Security shall be deemed to have been converted immediately prior to the close of business on the Business Day (the “Conversion
Date”) that the Holder has complied with the requirements set forth in subsection (b) above; provided that in the case of a Global Security, no Holder shall be deemed to have complied with the requirements set forth in
subsection (b) above on any Business Day that the Depositary is not open for business. Except as set forth in Section 4.04(b) and Section 4.07(a), the Company shall pay or deliver, as the case may be, the consideration due in respect
of the Conversion Obligation on the second Business Day immediately following the relevant Conversion Date, in the case of Physical Settlement, or on the second Business Day immediately following the last Trading Day of the Observation Period, in
the case of any other Settlement Method. If any shares of Common Stock are due to converting Holders, the Company shall issue or cause to be issued, and deliver to such Holder, or such Holder’s nominee or nominees, certificates or a book-entry
transfer through the Depositary for the full number of shares of Common Stock to which such Holder shall be entitled in satisfaction of the Company’s Conversion Obligation. 

  
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 (d) In case any Security shall be surrendered for partial conversion, the Company shall
execute and the Trustee shall authenticate and deliver to or upon the written order of the Holder of the Security so surrendered a new Security or Securities in authorized denominations in an aggregate principal amount equal to the unconverted
portion of the surrendered Security, without payment of any service charge by the converting Holder but, if required by the Company or Trustee, with payment of a sum sufficient to cover any transfer tax or similar governmental charge required by law
or that may be imposed in connection therewith as a result of the name of the Holder of the new Securities issued upon such conversion being different from the name of the Holder of the old Securities surrendered for such conversion. 

(e) If a Holder submits a Security for conversion, the Company shall pay any documentary, stamp or similar issue or transfer tax due on any
issuance of any shares of Common Stock upon the conversion, unless the tax is due because the Holder requests any shares to be issued in a name other than the Holder’s name, in which case the Holder shall pay that tax. The Company or its stock
transfer agent may refuse to deliver the certificates representing the shares of Common Stock being issued in a name other than the Holder’s name until the Company or its representative receives a sum sufficient to pay any tax that is due by
such Holder in accordance with the immediately preceding sentence. 
 (f) Upon the conversion of an interest in a Global Security, the
Trustee, or the Securities Custodian at the direction of the Trustee, shall make a notation on such Global Security as to the reduction in the principal amount represented thereby. The Company shall notify the Trustee in writing of any conversion of
Securities effected through any Conversion Agent other than the Trustee. 
 (g) Except as described below, the Company shall not make any
separate cash payment for accrued and unpaid interest, if any, upon conversion of Securities. The Company’s settlement of the Conversion Obligation shall be deemed to satisfy in full its obligation to pay the principal amount of the Security
and accrued and unpaid interest, if any, attributable to the period from, and including, the most recent Interest Payment Date to, but excluding, the relevant Conversion Date. As a result, accrued and unpaid interest, if any, to, but excluding, the
Conversion Date shall be deemed to be paid in full rather than cancelled, extinguished or forfeited. Upon a conversion of Securities into a combination of cash and shares of Common Stock, accrued and unpaid interest shall be deemed to be paid first
out of the cash paid upon such conversion. Notwithstanding the foregoing, if Securities are submitted for conversion after the close of business on a Regular Record Date and prior to the open of business on the immediately following Interest Payment
Date, Holders of such Securities as of the close of business on such Regular Record Date shall receive the full amount of interest payable on such Securities on such Interest Payment Date notwithstanding the conversion, and Securities surrendered
for conversion after the close of business on a Regular Record Date and prior to the open of business on the immediately following Interest Payment Date must be accompanied by funds equal to the amount of interest payable on the principal amount of
the Securities being converted; provided that no such payment need be made: 
 (i) for conversions after the close of
business on November 1, 2026, which is the Regular Record Date immediately preceding the Maturity Date; 

  
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 (ii) if the Company has specified a Redemption Date that is (A) after a
Regular Record Date and (B) on or prior to the Business Day immediately following the corresponding Interest Payment Date; 

(iii) if the Company has specified a Fundamental Change Repurchase Date that is (A) after a Regular Record Date and
(B) on or prior to the second Business Day immediately following the corresponding Interest Payment Date; or 
 (iv) to
the extent of any Defaulted Amounts, if any Defaulted Amounts exist at the time of conversion with respect to such Security. 
 As a result
of the foregoing, the Company shall pay interest on the Maturity Date on all Securities converted after the Regular Record Date preceding the Maturity Date, and Holders shall not be required to pay the Company equivalent interest amounts. For the
avoidance of doubt, each Holder of Securities at the close of business on the Regular Record Date immediately preceding the Maturity Date, any Fundamental Change Repurchase Date as described in the preceding paragraph or any Redemption Date as
described in the preceding paragraph, in each case, with respect to such Securities shall receive the full payment of accrued and unpaid interest on the Maturity Date or other applicable Interest Payment Date regardless of whether such Holder’s
Securities have been converted following such Regular Record Date. 
 (h) Upon a conversion of Securities, such Person shall no longer be a
Holder of such Securities surrendered for conversion. 
 (i) The Company shall not issue any fractional share of Common Stock upon conversion
of the Securities and shall instead pay cash in lieu of delivering any fractional share of Common Stock issuable upon conversion based on the Daily VWAP for the relevant Conversion Date (in the case of Physical Settlement) or based on the Daily VWAP
for the last Trading Day of the relevant Observation Period (in the case of Combination Settlement). For each Security surrendered for conversion, if the Company has elected (or is deemed to have elected) Combination Settlement, the full number of
shares that shall be issued upon conversion thereof shall be computed on the basis of the aggregate Daily Settlement Amounts for the applicable Observation Period and any fractional shares remaining after such computation shall be paid in cash. 

(j) Each conversion shall be deemed to have been effected as to any Security surrendered for conversion on the Conversion Date;
provided, however, that the Person in whose name any shares of Common Stock shall be issuable upon such conversion shall become the holder of record of such shares as of the close of business on the Conversion Date (in the case of
Physical Settlement) or the close of business on the last Trading Day of the relevant Observation Period (in the case of Combination Settlement). 

Section 4.03. Company to Provide Stock. The Company shall, prior to issuance of any Securities hereunder, and from time to time as
may be necessary, reserve, out of its authorized but unissued Common Stock, a sufficient number of shares of Common Stock to permit the conversion of all outstanding Securities into shares of Common Stock (assuming that at the time of computation of
such number of shares, all such Securities would be converted by a single Holder and that Physical Settlement (giving effect to the maximum number of Additional Shares pursuant to Section 4.04) is applicable). 

  
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 All shares of Common Stock delivered upon conversion of the Securities shall be newly issued
shares, shall be duly authorized, validly issued, fully paid and nonassessable and shall be free from preemptive rights and free of any lien or adverse claim. 

The Company shall endeavor promptly to comply with all federal and state securities laws regulating the offer and delivery of shares of Common
Stock upon conversion of Securities, if any, and will list or cause to have quoted such shares of Common Stock on each national securities exchange, over-the-counter
market or such other market on which the Common Stock is then listed or quoted; provided, however, that if rules of such automated quotation system or exchange permit the Company to defer the listing of such Common Stock until the
first conversion of the Securities into Common Stock in accordance with the provisions of this Indenture, the Company covenants to list such Common Stock issuable upon conversion of the Securities in accordance with the requirements of such
automated quotation system or exchange at such time. 
 Section 4.04. Adjustment to Conversion Rate upon a Make-Whole Fundamental
Change or Redemption Notice. (a) If and only to the extent that (i) a Holder converts its Securities in connection with a Make-Whole Fundamental Change that occurs prior to the Maturity Date or (ii) the Company gives a Redemption
Notice with respect to any or all of the Securities in accordance with Section 3.02 and a Holder elects to convert its Called Securities in connection with such Redemption Notice, the Company shall, under the circumstances set forth in this
Section 4.04, increase the Conversion Rate for the Securities so surrendered for conversion by a number of additional shares (the “Additional Shares”), as described below. 

(b) Upon surrender of Securities for conversion in connection with a Make-Whole Fundamental Change or Redemption Notice, the Company shall, at
its option, satisfy its Conversion Obligation by Physical Settlement, Cash Settlement or Combination Settlement in accordance with Section 4.02. However, if the consideration for the Common Stock in any Make-Whole Fundamental Change described
in clause (c) of the definition of Fundamental Change is composed entirely of cash, for any conversion of the Securities following the Effective Date of such Make-Whole Fundamental Change, the Conversion Obligation shall be calculated based
solely on the Stock Price for the transaction and shall be deemed to be an amount in cash per $1,000 principal amount of converted Securities equal to the Conversion Rate (including any increase to reflect the Additional Shares as described in this
Section 4.04), multiplied by such Stock Price. In such event, the Conversion Obligation shall be determined and paid to Holders in cash on the second Business Day following the Conversion Date. The Company shall notify in writing Holders
(with a copy to the Trustee and the Conversion Agent) of the Effective Date of any Make-Whole Fundamental Change and issue a press release announcing such Effective Date no later than five Business Days after such Effective Date. 

(c) The number of Additional Shares, if any, by which the Conversion Rate shall be increased shall be determined by reference to the table set
forth in clause (f) below, based on the date on which the Make-Whole Fundamental Change occurs or becomes effective or the date of the Redemption Notice, as the case may be (in each case, the “Effective Date”) and the price


  
 40 












 
(the “Stock Price”) paid (or deemed to be paid) per share of Common Stock in such Make-Whole Fundamental Change or with respect to the redemption, as the case may be. If holders
of Common Stock receive in exchange for their Common Stock only cash in a Make-Whole Fundamental Change described in clause (c) of the definition of Fundamental Change, the Stock Price shall be the cash amount paid per share of Common Stock.
Otherwise, the Stock Price shall be the average of the Last Reported Sale Prices of the Common Stock on each of the five consecutive Trading Days prior to, but excluding, the Effective Date of the Make-Whole Fundamental Change or the date of the
Redemption Notice, as the case may be. 
 (d) A conversion of Securities by a Holder shall be deemed for these purposes to be “in
connection with” a Make-Whole Fundamental Change if the Conversion Notice is received by the Conversion Agent on or after the Effective Date of the Make-Whole Fundamental Change and prior to the close of business on the Business Day immediately
preceding the related Fundamental Change Repurchase Date (or, in the case of a Make-Whole Fundamental Change that would have been a Fundamental Change but for the proviso in clause (c) of the definition of Fundamental Change, the 35th
Trading Day following the actual Effective Date of the Make-Whole Fundamental Change). A conversion of Securities will be deemed for these purposes to be “in connection with” a Redemption Notice if such Securities are Called Securities and
the relevant Conversion Date occurs during the related Redemption Period. For the avoidance of doubt, the Company shall increase the Conversion Rate during the related Redemption Period only with respect to conversions of Called Securities, and not
for Securities that are not Called Securities. 
 (e) The Stock Prices set forth in the first row of the following table (i.e., the column
headings) shall be adjusted as of any date on which the Conversion Rate is adjusted pursuant to Section 4.05. The adjusted Stock Prices shall equal the Stock Prices applicable immediately prior to such adjustment, multiplied by a
fraction, the numerator of which is the Conversion Rate immediately prior to the adjustment giving rise to the Stock Price adjustment and the denominator of which is the Conversion Rate as so adjusted. The number of Additional Shares will be
adjusted in the same manner, at the same time and for the same events as the Conversion Rate as set forth in Section 4.05. 
 (f) The
following table sets forth the number of Additional Shares by which the Conversion Rate for the Securities will be increased per $1,000 principal amount of Securities for each Stock Price and Effective Date set forth below: 

 

																																																	
	 	 	Stock Price	 
	 Effective Date
	 	$	7.96	 	 	$	9.00	 	 	$	10.75	 	 	$	12.00	 	 	$	13.98	 	 	$	15.00	 	 	$	17.50	 	 	$	20.00	 	 	$	22.50	 	 	$	25.00	 	 	$	30.00	 	 	$	40.00	 
		 	  
	  
	 	 	  
	  
	 	 	  
	  
	 	 	  
	  
	 	 	  
	  
	 	 	  
	  
	 	 	  
	  
	 	 	  
	  
	 	 	  
	  
	 	 	  
	  
	 	 	  
	  
	 	 	  
	  
	 
	 November 15, 2021
	 	 	32.5702	 	 	 	26.1856	 	 	 	17.7870	 	 	 	13.7583	 	 	 	9.3770	 	 	 	7.7600	 	 	 	4.9549	 	 	 	3.1955	 	 	 	2.0547	 	 	 	1.2984	 	 	 	0.4520	 	 	 	0.0000	 
	 November 15, 2022
	 	 	32.5702	 	 	 	25.6378	 	 	 	16.9888	 	 	 	12.9075	 	 	 	8.5494	 	 	 	6.9713	 	 	 	4.2880	 	 	 	2.6565	 	 	 	1.6316	 	 	 	0.9748	 	 	 	0.2807	 	 	 	0.0000	 
	 November 15, 2023
	 	 	32.5702	 	 	 	25.0222	 	 	 	15.9888	 	 	 	11.8258	 	 	 	7.5014	 	 	 	5.9793	 	 	 	3.4720	 	 	 	2.0200	 	 	 	1.1516	 	 	 	0.6240	 	 	 	0.1187	 	 	 	0.0000	 
	 November 15, 2024
	 	 	32.5702	 	 	 	24.0100	 	 	 	14.4167	 	 	 	10.1708	 	 	 	5.9714	 	 	 	4.5700	 	 	 	2.3926	 	 	 	1.2400	 	 	 	0.6116	 	 	 	0.2664	 	 	 	0.0083	 	 	 	0.0000	 
	 November 15, 2025
	 	 	32.5702	 	 	 	21.8622	 	 	 	11.3814	 	 	 	7.1608	 	 	 	3.4807	 	 	 	2.4140	 	 	 	0.9829	 	 	 	0.3755	 	 	 	0.1129	 	 	 	0.0128	 	 	 	0.0000	 	 	 	0.0000	 
	 November 15, 2026
	 	 	32.5702	 	 	 	18.0533	 	 	 	0.0000	 	 	 	0.0000	 	 	 	0.0000	 	 	 	0.0000	 	 	 	0.0000	 	 	 	0.0000	 	 	 	0.0000	 	 	 	0.0000	 	 	 	0.0000	 	 	 	0.0000	 


  
 41 












 The exact Stock Price and Effective Date may not be set forth in the table above, in which
case: 
 (i) if the Stock Price is between two Stock Prices in the table or the Effective Date is between two Effective Dates
in the table, the number of Additional Shares by which the Conversion Rate for the Securities will be increased shall be determined by straight-line interpolation between the number of Additional Shares set forth for the higher and lower Stock
Prices and the earlier and later Effective Dates, as applicable, based on a 365-day year; 

(ii) if the Stock Price is more than $40.00 per share (subject to adjustment in the same manner as the Stock Prices set forth
in the column headings of the table above), no Additional Shares shall be added to the Conversion Rate; and 
 (iii) if the
Stock Price is less than $7.96 per share (subject to adjustment in the same manner as the Stock Prices set forth in the column headings of the table), no Additional Shares shall be added to the Conversion Rate. 

Notwithstanding the foregoing, in no event shall the Conversion Rate per $1,000 principal amount of Securities exceed 125.6281 shares of
Common Stock, subject to adjustment in the same manner, at the same time and for the same events as the Conversion Rate as set forth in Section 4.05. 

Section 4.05. Conversion Rate Adjustments. The Conversion Rate shall be adjusted from time to time by the Company, upon the
occurrence of any of the following events, except that the Company shall not make any adjustments to the Conversion Rate if Holders of the Securities participate (other than in the case of (i) a share split or share combination or (ii) a
tender or exchange offer), at the same time and upon the same terms as holders of the Common Stock and solely as a result of holding the Securities, in any of the events described in this Section 4.05, without having to convert their Securities
as if they held a number of shares of Common Stock equal to the Conversion Rate, multiplied by the principal amount (expressed in thousands) of Securities held by such Holder. 

(a) If the Company exclusively issues shares of Common Stock as a dividend or distribution on shares of its Common Stock, or if the Company
effects a share split or share combination, the Conversion Rate shall be adjusted based on the following formula: 
  

									
		 	CR’ = CR0	 	x	 	        OS’
	 	
	 	  OS0	 	

 where, 
  

					
	CR0	  	=	  	the Conversion Rate in effect immediately prior to the open of business on the Ex-Dividend Date of such dividend or distribution, or immediately prior to the open of business on the Effective
Date of such share split or share combination, as applicable;


  
 42 













					
	CR’	  	=	  	the Conversion Rate in effect immediately after the open of business on such Ex-Dividend Date or Effective Date;
			
	OS0	  	=	  	the number of shares of Common Stock outstanding immediately prior to the open of business on such Ex-Dividend Date or Effective Date; and
			
	OS’	  	=	  	the number of shares of Common Stock outstanding immediately after, and solely as a result of, giving effect to such dividend, distribution, share split or share combination.

 Any adjustment made under this Section 4.05(a) shall become effective immediately after the open of
business on the Ex-Dividend Date for such dividend or distribution, or immediately after the open of business on the Effective Date for such share split or share combination, as applicable. If any dividend or
distribution of the type described in this Section 4.05(a) is declared but not so paid or made, the Conversion Rate shall be immediately readjusted, effective as of the date the Board of Directors determines not to pay such dividend or
distribution, to the Conversion Rate that would then be in effect if such dividend or distribution had not been declared. 
 (b) If the
Company issues to all or substantially all holders of its Common Stock any rights, options or warrants entitling them, for a period of not more than 60 calendar days after the announcement date of such issuance, to subscribe for or purchase shares
of Common Stock at a price per share that is less than the average of the Last Reported Sale Prices of the Common Stock for the ten consecutive Trading Day period ending on, and including, the Trading Day immediately preceding the date of
announcement of such issuance, the Conversion Rate shall be increased based on the following formula: 
  

									
		 	CR’ = CR0	 	  x  	 	     

  OS0 + X  
	  	
	 	  OS0 + Y  	  	

 where, 
  

					
	CR0	  	=	  	the Conversion Rate in effect immediately prior to the open of business on the Ex-Dividend Date for such issuance;
			
	CR’	  	=	  	the Conversion Rate in effect immediately after the open of business on such Ex-Dividend Date;
			
	OS0	  	=	  	the number of shares of Common Stock outstanding immediately prior to the open of business on such Ex-Dividend Date;
			
	X	  	=	  	the total number of shares of Common Stock issuable pursuant to such rights, options or warrants; and
			
	Y	  	=	  	the number of shares of Common Stock equal to the aggregate price payable to exercise such rights, options or warrants, divided by the average of the Last Reported Sale Prices of the Common Stock over the ten consecutive
Trading Day period ending on, and including, the Trading Day immediately preceding the date of announcement of the issuance of such rights, options or warrants.


  
 43 












 Any increase made under this Section 4.05(b) shall be made successively whenever any
such rights, options or warrants are issued and shall become effective immediately after the open of business on the Ex-Dividend Date for such issuance. To the extent that shares of Common Stock are not
delivered after the expiration of such rights, options or warrants, the Conversion Rate shall be decreased to the Conversion Rate that would then be in effect had the increase with respect to the issuance of such rights, options or warrants been
made on the basis of delivery of only the number of shares of Common Stock actually delivered. If such rights, options or warrants are not so issued, or if no such rights, options or warrants are exercised prior to their expiration, the Conversion
Rate shall be decreased to the Conversion Rate that would then be in effect if such Ex-Dividend Date for such issuance had not occurred. 

For purposes of this Section 4.05(b) and for the purpose of Section 4.01(e)(i), in determining whether any rights, options or
warrants entitle the holders to subscribe for or purchase shares of the Common Stock at less than such average of the Last Reported Sale Prices of the Common Stock for the ten consecutive Trading Day period ending on, and including, the Trading Day
immediately preceding the date of announcement for such issuance, and in determining the aggregate offering price of such shares of Common Stock, there shall be taken into account any consideration received by the Company for such rights, options or
warrants and any amount payable on exercise or conversion thereof, the value of such consideration, if other than cash, to be determined by the Board of Directors. 

(c) If the Company distributes shares of its Capital Stock, evidences of its indebtedness, other assets or property of the Company or rights,
options or warrants to acquire its Capital Stock or other securities, to all or substantially all holders of the Common Stock, excluding (i) dividends, distributions or issuances as to which an adjustment was effected pursuant to
Section 4.05(a) or Section 4.05(b), (ii) rights issued under a stockholder rights plan (except as set forth below in Section 4.09), (iii) dividends or distributions paid exclusively in cash as to which the provisions set forth in
Section 4.05(d) shall apply, (iv) distributions of Reference Property in exchange for the Common Stock as described in Section 4.07 and (v) Spin-Offs as to which the provisions set forth below in this Section 4.05(c) shall
apply, then the Conversion Rate shall be increased based on the following formula: 
  

									
		 	CR’ = CR0	 	  x  	 	     

        SP0   
  
	  	
	 	SP0 – FMV	  	

 where, 
  

					
	CR0	  	=	  	the Conversion Rate in effect immediately prior to the open of business on the Ex-Dividend Date for such distribution;


  
 44 













					
	CR’	  	=	  	the Conversion Rate in effect immediately after the open of business on such Ex-Dividend Date;
			
	SP0	  	=	  	the average of the Last Reported Sale Prices of the Common Stock over the ten consecutive Trading Day period ending on, and including, the Trading Day immediately preceding the Ex-Dividend
Date for such distribution; and
			
	FMV	  	=	  	the fair market value (as determined by the Board of Directors) of the shares of Capital Stock, evidences of indebtedness, assets, property, rights, options or warrants to acquire Capital Stock or other securities of the Company
(the “Distributed Property”) distributed with respect to each outstanding share of the Common Stock on the Ex-Dividend Date for such distribution.

 Any increase made under the portion of this Section 4.05(c) above shall become effective immediately
after the open of business on the Ex-Dividend Date for such distribution. If such distribution is not so paid or made, the Conversion Rate shall be decreased to the Conversion Rate that would then be in effect
if such distribution had not been declared. Notwithstanding the foregoing, if “FMV” (as defined above) is equal to or greater than “SP0” (as defined above), in lieu of the
foregoing increase, each Holder of a Security shall receive, in respect of each $1,000 principal amount thereof, at the same time and upon the same terms as holders of the Common Stock receive the Distributed Property, the amount and kind of
Distributed Property such Holder would have received if such Holder owned a number of shares of Common Stock equal to the Conversion Rate in effect on the Ex-Dividend Date for the distribution. If the Board of
Directors determines the “FMV” (as defined above) of any distribution for purposes of this Section 4.05(c) by reference to the actual or when-issued trading market for any securities, it shall in doing so consider the prices in such
market over the same period used in computing the Last Reported Sale Prices of the Common Stock over the ten consecutive Trading Day period ending on the Trading Day immediately preceding the Ex-Dividend Date
for such distribution. 
 With respect to an adjustment pursuant to this Section 4.05(c) where there has been a payment of a dividend
or other distribution on the Common Stock of shares of Capital Stock of any class or series, or similar equity interest, of or relating to a Subsidiary or other business unit of the Company, that are, or, when issued, will be, listed or admitted for
trading on a U.S. national securities exchange (a “Spin-Off”), the Conversion Rate shall be increased based on the following formula: 

 

									
		 	CR’ = CR0	 	  x  	 	     

  FMV0 + MP0  
	  	
	 	        MP0	  	

 where, 
  

					
	CR0	  	=	  	the Conversion Rate in effect immediately prior to the end of the Valuation Period;


  
 45 













					
	CR’	  	=	  	the Conversion Rate in effect immediately after the end of the Valuation Period;
			
	FMV0	  	=	  	the average of the Last Reported Sale Prices of the Capital Stock or similar equity interest distributed to holders of the Common Stock applicable to one share of the Common Stock (determined by reference to the definition of Last
Reported Sale Price as if references therein to Common Stock were to such Capital Stock or similar equity interest) over the first ten consecutive Trading Day period after, and including, the Ex-Dividend Date
of the Spin-Off (the “Valuation Period”); and
			
	MP0	  	=	  	the average of the Last Reported Sale Prices of the Common Stock over the Valuation Period.

 The increase to the Conversion Rate under the preceding paragraph shall occur at the close of business on the
last Trading Day of the Valuation Period; provided that (x) in respect of any conversion of Securities for which Physical Settlement is applicable, if the relevant Conversion Date occurs during the Valuation Period, the reference to
“ten” in the preceding paragraph shall be deemed replaced with such lesser number of Trading Days as have elapsed from, and including, the Ex-Dividend Date for such
Spin-Off to, and including, such Conversion Date in determining the Conversion Rate and (y) in respect of any conversion of Securities for which Cash Settlement or Combination Settlement is applicable,
for any Trading Day that falls within the relevant Observation Period for such conversion and within the Valuation Period, the reference to “ten” in the preceding paragraph shall be deemed replaced with such lesser number of Trading Days
as have elapsed from, and including, the Ex-Dividend Date for such Spin-Off to, and including, such Trading Day in determining the Conversion Rate as of such Trading
Day. If the distribution constituting the Spin-Off is not so paid or made, the Conversion Rate shall be decreased to the Conversion Rate that would have been in effect if such distribution had not been
declared. 
 For purposes of the foregoing, “FMV0” will be determined by
reference to (i) the actual trading market for the Capital Stock or similar equity interest to be distributed in the Spin-Off or (ii) for any Trading Day in the Valuation Period as of which such
Capital Stock or similar equity interest has not commenced trading in the actual trading market for such security, the when-issued trading market for such security, as applicable. 

For purposes of this Section 4.05(c) (and subject in all respects to Section 4.09), rights, options or warrants distributed by the
Company, pursuant to a shareholder rights plan to all or substantially all holders of its Common Stock entitling them to subscribe for or purchase shares of the Company’s Capital Stock, including Common Stock (either initially or under certain
circumstances), which rights, options or warrants, until the occurrence of a specified event or events (“Trigger Event”): (i) are deemed to be transferred with such shares of the Common Stock; (ii) are not exercisable; and
(iii) are also issued in respect of future issuances of the Common Stock, shall be deemed not to have been distributed for purposes of this Section 4.05(c) (and no adjustment to the Conversion Rate under this Section 4.05(c) will be
required) until the occurrence of the earliest Trigger Event, whereupon such rights, options or warrants shall be deemed to have been distributed and an appropriate adjustment (if any is required) to the


  
 46 












 
Conversion Rate shall be made under this Section 4.05(c). If any such right, option or warrant, including any such existing rights, options or warrants distributed prior to the date of this
Indenture, are subject to events, upon the occurrence of which such rights, options or warrants become exercisable to purchase different securities, evidences of indebtedness or other assets, then the date of the occurrence of any and each such
event shall be deemed to be the date of distribution and Ex-Dividend Date with respect to new rights, options or warrants with such rights (in which case the existing rights, options or warrants shall be
deemed to terminate and expire on such date without exercise by any of the holders thereof). In addition, in the event of any distribution (or deemed distribution) of rights, options or warrants, or any Trigger Event or other event (of the type
described in the immediately preceding sentence) with respect thereto that was counted for purposes of calculating a distribution amount for which an adjustment to the Conversion Rate under this Section 4.05(c) was made, (1) in the case of
any such rights, options or warrants that shall all have been redeemed or purchased without exercise by any holders thereof, upon such final redemption or purchase (x) the Conversion Rate shall be readjusted as if such rights, options or
warrants had not been issued and (y) the Conversion Rate shall then again be readjusted to give effect to such distribution, deemed distribution or Trigger Event, as the case may be, as though it were a cash distribution, equal to the per share
redemption or purchase price received by a holder or holders of Common Stock with respect to such rights, options or warrants (assuming such holder had retained such rights, options or warrants), made to all holders of Common Stock as of the date of
such redemption or purchase, and (2) in the case of such rights, options or warrants that shall have expired or been terminated without exercise by any holders thereof, the Conversion Rate shall be readjusted as if such rights, options and
warrants had not been issued. 
 For purposes of Section 4.05(a), Section 4.05(b) and this Section 4.05(c), any dividend or
distribution to which this Section 4.05(c) is applicable that also includes one or both of: 
 (A) a dividend or
distribution of shares of Common Stock to which Section 4.05(a) is applicable (the “Clause A Distribution”); or 

(B) a dividend or distribution of rights, options or warrants to which Section 4.05(b) is applicable (the “Clause
B Distribution”), 
 then (1) such dividend or distribution, other than the Clause A Distribution and the Clause B Distribution, shall be
deemed to be a dividend or distribution to which this Section 4.05(c) is applicable (the “Clause C Distribution”) and any Conversion Rate adjustment required by this Section 4.05(c) with respect to such Clause C
Distribution shall then be made, and (2) the Clause A Distribution and Clause B Distribution shall be deemed to immediately follow the Clause C Distribution and any Conversion Rate adjustment required by Section 4.05(a) and
Section 4.05(b) with respect thereto shall then be made, except that, if determined by the Company, (I) the “Ex-Dividend Date” of the Clause A Distribution and the Clause B
Distribution shall be deemed to be the Ex-Dividend Date of the Clause C Distribution and (II) any shares of Common Stock included in the Clause A Distribution or Clause B Distribution shall be deemed not
to be “outstanding immediately prior to the open of business on such Ex-Dividend Date or Effective Date” within the meaning of Section 4.05(a) or “outstanding immediately prior to the open
of business on such Ex-Dividend Date” within the meaning of Section 4.05(b). 

  
 47 












 (d) If the Company makes any cash dividend or distribution to all or substantially all
holders of the Common Stock, the Conversion Rate shall be adjusted based on the following formula: 
  

									
		 	CR’ = CR0	 	   x   	 	     

      SP0     
 
	 	
	 	   SP0 – C	 	

 where, 
  

					
	CR0	  	=	  	the Conversion Rate in effect immediately prior to the open of business on the Ex-Dividend Date for such dividend or distribution;
			
	CR’	  	=	  	the Conversion Rate in effect immediately after the open of business on the Ex-Dividend Date for such dividend or distribution;
			
	SP0	  	=	  	the Last Reported Sale Price of the Common Stock on the Trading Day immediately preceding the Ex-Dividend Date for such dividend or distribution; and
			
	C	  	=	  	the amount in cash per share the Company distributes to holders of its Common Stock.

 Any increase pursuant to this Section 4.05(d) shall become effective immediately after the open of
business on the Ex-Dividend Date for such dividend or distribution. If such dividend or distribution is not so paid, the Conversion Rate shall be decreased, effective as of the date the Board of Directors
determines not to make or pay such dividend or distribution, to the Conversion Rate that would then be in effect if such dividend or distribution had not been declared. Notwithstanding the foregoing, if “C” (as defined above) is equal to
or greater than “SP0” (as defined above), in lieu of the foregoing increase, each Holder of a Security shall receive, for each $1,000 principal amount of Securities, at the same time
and upon the same terms as holders of shares of the Common Stock, the amount of cash that such Holder would have received if such Holder owned a number of shares of Common Stock equal to the Conversion Rate on the
Ex-Dividend Date for such cash dividend or distribution. 
 (e) If the Company or any of its
Subsidiaries makes a payment in respect of a tender or exchange offer for the Common Stock, to the extent that the cash and value of any other consideration included in the payment per share of the Common Stock exceeds the average of the Last
Reported Sale Prices of the Common Stock over the ten consecutive Trading Day period commencing on, and including, the Trading Day next succeeding the last date on which tenders or exchanges may be made pursuant to such tender offer or exchange
offer, as the case may be, the Conversion Rate shall be increased based on the following formula: 
  

									
		 	CR’ = CR0	 	   x   	 	     

AC + (SP’ x OS’)
	 	
	 	OS0 x SP’	 	

 where, 

  
 48 













					
	CR0	  	=	  	the Conversion Rate in effect immediately prior to the close of business on the tenth Trading Day immediately following, and including, the Trading Day next succeeding the date such tender or exchange offer expires;
			
	CR’	  	=	  	the Conversion Rate in effect immediately after the close of business on the tenth Trading Day immediately following, and including, the Trading Day next succeeding the date such tender or exchange offer expires;
			
	AC	  	=	  	the aggregate value of all cash and any other consideration (as determined by the Board of Directors) paid or payable for shares of Common Stock purchased in such tender or exchange offer;
			
	OS0	  	=	  	the number of shares of Common Stock outstanding immediately prior to the date such tender or exchange offer expires (prior to giving effect to the purchase of all shares of Common Stock accepted for purchase or exchange in such
tender or exchange offer);
			
	OS’	  	=	  	the number of shares of Common Stock outstanding immediately after the date such tender or exchange offer expires (after giving effect to the purchase of all shares of Common Stock accepted for purchase or exchange in such tender or
exchange offer); and
			
	SP’	  	=	  	the average of the Last Reported Sale Prices of the Common Stock over the ten consecutive Trading Day period commencing on, and including, the Trading Day next succeeding the date such tender or exchange offer expires.

 The increase to the Conversion Rate under this Section 4.05(e) shall occur at the close of business on
the tenth Trading Day immediately following, and including, the Trading Day next succeeding the date such tender or exchange offer expires; provided that (x) in respect of any conversion of Securities for which Physical Settlement is
applicable, if the relevant Conversion Date occurs during the ten Trading Days immediately following, and including, the Trading Day next succeeding the date any tender or exchange offer expires, references to “ten” or “tenth” in
the preceding paragraph shall be deemed replaced with such lesser number of trading days as have elapsed from, and including, the Trading Day next succeeding the date such tender or exchange offer expires to, and including, such Conversion Date in
determining the Conversion Rate and (y) in respect of any conversion of Securities for which Cash Settlement or Combination Settlement is applicable, for any Trading Day that falls within the relevant Observation Period for such conversion and
within the ten Trading Days immediately following, and including, the Trading Day next succeeding the date any tender or exchange offer expires, references to “ten” or “tenth” in the preceding paragraph shall be deemed replaced
with such lesser number of Trading Days as have elapsed from, and including, the Trading Day next succeeding the date such tender or exchange offer expires to, and including, such Trading Day in determining the Conversion Rate as of such Trading
Day. For the avoidance of doubt, no adjustment under Section 4.05(e) will be made if such adjustment would result in a decrease in the applicable Conversion Rate. 

  
 49 












 (f) Notwithstanding this Section 4.05 or any other provision of this Indenture or the
Securities, if a Conversion Rate adjustment becomes effective on any Ex-Dividend Date, and a Holder that has converted its Securities on or after such Ex-Dividend Date
and on or prior to the related Record Date would be treated as the record holder of the Common Stock as of the related Conversion Date as described under Section 4.02(j) based on an adjusted Conversion Rate for such Ex-Dividend Date, then, notwithstanding the Conversion Rate adjustment provisions in this Section 4.05, the Conversion Rate adjustment relating to such Ex-Dividend Date
shall not be made for such converting Holder. Instead, such Holder shall be treated as if such Holder were the record owner of the shares of Common Stock on an unadjusted basis and participate in the related dividend, distribution or other event
giving rise to such adjustment. 
 (g) Except as stated herein, the Company shall not adjust the Conversion Rate for the issuance of shares
of its Common Stock or any securities convertible into or exchangeable for shares of its Common Stock or the right to purchase shares of its Common Stock or such convertible or exchangeable securities. In addition, the Company shall not adjust the
Conversion Rate for guarantees issued in respect of any of its outstanding securities. 
 (h) In addition to those adjustments required by
subsections (a), (b), (c), (d) and (e) of this Section 4.05, and to the extent permitted by applicable law and subject to the applicable rules of The Nasdaq Global Select Market, the Company from time to time may increase the Conversion
Rate by any amount for any period of at least 20 Business Days if the Board of Directors has determined that such increase would be in the Company’s best interest. In addition, the Company may (but is not required to), subject to the applicable
rules of The Nasdaq Global Select Market, increase the Conversion Rate, as the Board of Directors considers advisable, to avoid or diminish any income tax to holders of Common Stock or rights to purchase Common Stock resulting from any dividend or
distribution of stock (or rights to acquire stock) or from any event treated as such for tax purposes. Whenever the Conversion Rate is increased pursuant to either of the preceding two sentences, the Company shall mail to the Holder of each Security
at its last address appearing on the register of the Primary Registrar, the Trustee and the Conversion Agent a written notice of the increase at least 15 days prior to the date the increased Conversion Rate takes effect, and such notice shall state
the increased Conversion Rate and the period during which it will be in effect. 
 (i) Notwithstanding anything to the contrary in this
Section 4.05, the Conversion Rate shall not be adjusted: 
 (i) upon the issuance of any shares of Common Stock pursuant
to any present or future plan providing for the reinvestment of dividends or interest payable on the Company’s securities and the investment of additional optional amounts in shares of Common Stock under any plan; 

(ii) upon the issuance of any shares of Common Stock or options or rights to purchase those shares pursuant to any present or
future employee, director or consultant benefit plan or program of or assumed by the Company or any of its Subsidiaries; 

  
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 (iii) on account of stock repurchases, including structured or derivative
transactions, in each case, that are not tender offers or exchange offers referred to in Section 4.05(e) of the adjustments above; 

(iv) upon the issuance of any shares of Common Stock pursuant to any option, warrant, right (other than rights under a
shareholder rights plan as described in Section 4.09) or exercisable, exchangeable or convertible security not described in Section 4.05(b) or Section 4.05(c) and outstanding as of the date the Securities were first issued; 

(v) solely for a change in the par value of the Common Stock; or 

(vi) for accrued and unpaid interest, if any. 

(j) Notwithstanding anything to the contrary in this Indenture, the Company shall not be required to make an adjustment pursuant to clauses
(a), (b), (c), (d) or (e) of this Section 4.05 unless such adjustment would result in a change of at least 1% of the Conversion Rate. However, the Company shall carry forward any adjustments that are less than 1% of the Conversion Rate and
make such carried forward adjustments with respect to the Securities, except that all such adjustments must be given effect immediately upon the earliest to occur of any of the following: (1) when all such deferred adjustments would result in
an aggregate change of at least 1% to the Conversion Rate; and (2) regardless of whether the adjustment (or such cumulative net effect) is less than 1% of the Conversion Rate (i) (x) on the Conversion Date for any Securities (in the case
of Physical Settlement) and (y) on each Trading Day of any Observation Period for any Securities (in the case of Cash Settlement or Combination Settlement); (ii) on the date any Fundamental Change or Make-Whole Fundamental Change occurs or
becomes effective; (iii) the date the Company sends a Redemption Notice for all or any Securities; and (iv) June 15, 2026. All calculations and other determinations in respect of the Conversion Rate shall be made by the Company to the
nearest 1/10,000th of a share. 
 (k) Whenever the Conversion Rate is adjusted pursuant to this Section 4.05, the Company shall compute
the adjusted Conversion Rate in accordance with this Section 4.05 and shall prepare an Officers’ Certificate setting forth (i) the adjusted Conversion Rate, (ii) the subsection of this Section 4.05 pursuant to which such
adjustment has been made, showing in reasonable detail the facts upon which such adjustment is based, (iii) the calculation of such adjustment and (iv) the date as of which such adjustment is effective, and such Officers’ Certificate
shall promptly be delivered to the Trustee and each Conversion Agent (which certificates shall be conclusive evidence of the accuracy of such adjustment absent manifest error). As soon as practicable after each such adjustment, the Company shall
deliver to the Holders (with a copy to the Trustee and the Conversion Agent) a notice stating that the Conversion Rate has been adjusted and setting forth the adjusted Conversion Rate and setting forth the date as of which such adjustment is
effective. Failure to deliver such notice shall not affect the legality or validity of any such adjustment. Unless and until a Responsible Officer of the Trustee and each Conversion Agent shall receive an Officers’ Certificate with respect to
an adjustment of the Conversion Rate, the Trustee and each Conversion Agent may assume without inquiry that the Conversion Rate has not been adjusted and that the last Conversion Rate of which it has knowledge remains in effect. Neither the Trustee
nor any Conversion Agent shall be under any duty or responsibility with respect to any such certificate or the information and calculations contained therein, except to exhibit the same to any Holder of Securities desiring inspection thereof at its
office during normal business hours. 

  
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 (l) For purposes of this Section 4.05, the number of shares of Common Stock at any time
outstanding shall not include shares held in the treasury of the Company so long as the Company does not pay any dividend or make any distribution on shares of Common Stock held in the treasury of the Company, but shall include shares issuable in
respect of scrip certificates issued in lieu of fractions of shares of Common Stock. 
 (m) In the event of a taxable distribution to holders
of shares of Common Stock that results in an adjustment of the Conversion Rate, Holders may, in certain circumstances, be deemed to have received a distribution subject to U.S. federal income tax as a dividend. Because this deemed distribution would
not give rise to any cash from which any applicable withholding tax could be satisfied, if withholding taxes (including any backup withholding) are paid on behalf of a Holder, those withholding taxes may be set off against payments of cash or Common
Stock, if any, payable on the Securities (or, in some circumstances, against any payments on the Common Stock). 
 (n) Notwithstanding any of
the foregoing, if: 
 (i) the Company elects (or is deemed to have elected) to satisfy its Conversion Obligation through
Combination Settlement and shares of Common Stock are deliverable to settle the Daily Settlement Amount for a given Trading Day within the Observation Period applicable to Securities that a Holder has converted; 

(ii) any distribution or transaction described in subsections (a), (b), (c), (d) or (e) of this Section 4.05 has not
yet resulted in an adjustment to the Conversion Rate on the Trading Day in question; and 
 (iii) the shares of Common Stock
that such Holder will receive in respect of such Trading Day are not entitled to participate in the relevant distribution or transaction (because such shares of Common Stock were not held on a related Record Date or otherwise), 

then such Holder will be treated as if such Holder were the record owner of such shares of Common Stock on an unadjusted basis and participate in the related
dividend, distribution or other event giving rise to such adjustment and the Company shall take such corporate actions as required to give effect to the foregoing. 

(o) Notwithstanding any of the foregoing, if: 

(i) the Company elects to satisfy (or is otherwise required to satisfy) its Conversion Obligation solely in shares of Common
Stock (other than cash in lieu of any fractional shares); 
 (ii) any distribution or transaction described in subsections
(a), (b), (c), (d) or (e) of this Section 4.05 has not yet resulted in an adjustment to the Conversion Rate on a given Conversion Date; and 

  
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 (iii) the shares of Common Stock deliverable on settlement of the related
conversion are not entitled to participate in the relevant distribution or transaction (because such shares of Common Stock were not held on a related Record Date or otherwise), 

then such Holder will be treated as if such Holder were the record owner of such shares of Common Stock on an unadjusted basis and participate in the related
dividend, distribution or other event giving rise to such adjustment and the Company shall take such corporate actions as required to give effect to the foregoing. 

Section 4.06. Adjustments of Prices. Whenever any provision of this Indenture requires the Company to calculate the Last Reported
Sale Prices, the Daily VWAPs, the Daily Conversion Values or the Daily Settlement Amounts over a span of multiple days (including an Observation Period and the period for determining the Stock Price for purposes of a Make-Whole Fundamental Change or
Redemption Notice), the Board of Directors shall make appropriate adjustments to each to account for any adjustment to the Conversion Rate that becomes effective, or any event requiring an adjustment to the Conversion Rate where the Ex-Dividend Date, the Effective Date or the expiration date of the event occurs, at any time during the relevant period. 

Section 4.07. Effect of Recapitalizations, Reclassifications and Changes of the Common Stock. 

(a) In the case of: 

(i) any recapitalization, reclassification or change of the Common Stock (other than changes resulting from a subdivision or
combination), 
 (ii) any consolidation, merger or combination involving the Company, 

(iii) any sale, lease or other transfer to a third party of the consolidated assets of the Company and the Company’s
Subsidiaries substantially as an entirety or 
 (iv) any statutory share exchange, 

in each case, as a result of which the Common Stock would be converted into, or exchanged for, stock, other securities, other property or assets (including
cash or any combination thereof) (any such event, a “Merger Event”), then the Company or the successor or purchasing company, as the case may be, will execute with the Trustee, without the consent of the Holders, a supplemental
indenture providing that, at and after the effective time of such Merger Event, the right to convert each $1,000 principal amount of Securities shall be changed into a right to convert such principal amount of Securities into the kind and amount of
shares of stock, other securities or other property or assets (including cash or any combination thereof) that a holder of a number of shares of Common Stock equal to the Conversion Rate immediately prior to such Merger Event would have owned or
been entitled to receive (the “Reference Property,” with each “unit of Reference Property” meaning the kind and amount of Reference Property that a holder of one share of Common Stock is entitled to receive) upon
such Merger Event; provided, however, that at and after the effective time of the Merger Event, (A) the Company shall 

  
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continue to have the right to determine the form of consideration to be paid or delivered, as the case may be, upon conversion of Securities in accordance with Section 4.02 and (B)(I) any
amount payable in cash upon conversion of the Securities in accordance with Section 4.02 shall continue to be payable in cash, (II) any shares of Common Stock that the Company would have been required to deliver upon conversion of the
Securities in accordance with Section 4.02 shall instead be deliverable in the amount and type of Reference Property that a holder of that number of shares of Common Stock would have been entitled to receive in such Merger Event and
(III) the Daily VWAP shall be calculated based on the value of a unit of Reference Property that a holder of one share of Common Stock would have received in such transaction. If the Merger Event causes the Common Stock to be converted into, or
exchanged for, the right to receive more than a single type of consideration (determined based in part upon any form of shareholder election), then the Reference Property into which the Securities will be convertible shall be deemed to be the
weighted average of the types and amounts of consideration actually received by the holders of Common Stock. The Company shall notify Holders, the Trustee and the Conversion Agent (if other than the Trustee) in writing of the weighted average as
soon as practicable after the determination is made. 
 Such supplemental indenture shall provide for anti-dilution and other adjustments
that are as nearly equivalent as possible to the adjustments provided for in this Article 4. If the Reference Property in respect of any Merger Event includes shares of stock, securities or other property or assets of a Person other than the Company
or the successor or purchasing corporation, as the case may be, in such Merger Event, such other Person will also execute such supplemental indenture, and such supplemental indenture shall contain such additional provisions to protect the interests
of the Holders, including the right of Holders to require the Company to repurchase their Securities upon a Fundamental Change pursuant to Article 3, as the Board of Directors shall reasonably consider necessary by reason of the foregoing. 

If the holders of Common Stock receive only cash in such Merger Event, then for all conversions of Securities that occur after the effective
date of such Merger Event (x) the consideration due upon conversion of each $1,000 principal amount of Securities shall be solely cash in an amount equal to the Conversion Rate in effect on the Conversion Date (as may be increased pursuant to
Section 4.04), multiplied by the price paid per share of Common Stock in such Merger Event and (y) the Company shall satisfy the Conversion Obligation by paying cash to converting Holders on the second Business Day immediately
following the Conversion Date. 
 (b) Upon execution of a supplemental indenture pursuant to subsection (a) of this Section 4.07,
the Company shall promptly file with the Trustee an Officers’ Certificate briefly stating the reasons therefor, the kind or amount of cash, securities or property or asset that will comprise the Reference Property after any such Merger Event,
any adjustment to be made with respect thereto and that all conditions precedent have been complied with, and shall promptly mail notice thereof to all Holders. The Company shall cause notice of the execution of such supplemental indenture to be
mailed to each Holder, at its address appearing on the register of the Primary Registrar (with a copy to the Trustee) provided for in this Indenture, within 20 days after execution thereof. Failure to deliver such notice shall not affect the
legality or validity of such supplemental indenture. 

  
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 (c) The Company shall not become a party to any Merger Event unless its terms are consistent
with this Section 4.07. None of the foregoing provisions shall affect the right of a Holder of Securities to convert its Securities into cash, shares of Common Stock or a combination of cash and shares of Common Stock, as applicable, as set
forth in Section 4.01 and Section 4.02 prior to the effective date of such Merger Event. 
 (d) The above provisions of this
Section 4.07 shall similarly apply to successive Merger Events. 
 Section 4.08. Cancellation of Converted Securities. All
Certificated Securities delivered for conversion shall be delivered to the Trustee or its agent to be canceled by or at the direction of the Trustee, which shall dispose of the same as provided in this Indenture. Upon conversions of beneficial
interests in any Global Security, the Trustee or the Securities Custodian, at the direction of the Trustee, shall reduce the aggregate principal amount of outstanding Securities represented by such Global Security to reflect the conversion. 

Section 4.09. Shareholders Rights. If the Company has a shareholder rights plan in effect upon conversion of the Securities, each
share of Common Stock, if any, issued upon such conversion shall be entitled to receive the appropriate number of rights, if any, under such shareholder rights plan and the certificates representing the Common Stock issued upon such conversion shall
bear such legends, if any, in each case as may be provided by the terms of any such shareholder rights plan, as the same may be amended from time to time (such rights prior to separation from the Common Stock,
“Non-Separate Rights”). However, if prior to any conversion the rights have separated from the shares of Common Stock in accordance with the provisions of the applicable shareholder rights
plan so that the Holders would not be entitled to receive any rights in respect of Common Stock, if any, issuable upon conversion of the Securities, the Conversion Rate shall be increased at the time of separation as if the Company distributed to
all or substantially all holders of Common Stock shares of Capital Stock of the Company, evidences of its indebtedness, other assets or property or rights, options or warrants to acquire its Capital Stock or other securities as provided in
Section 4.05(c), subject to decrease in the event of the expiration, termination or redemption of such rights. A distribution of rights pursuant to such a shareholder rights plan shall not trigger a Conversion Rate adjustment pursuant to
Section 4.05(c) if Holders of the Securities participate in such distribution on an as-converted basis in accordance with the first paragraph of Section 4.05. 

Section 4.10. Trustee’s Disclaimer. The Trustee shall have no duty to determine when an adjustment to the
Conversion Rate under this Article 4 should be made, how it should be made or what such adjustment should be, but may accept as conclusive evidence of that fact or the correctness of any such adjustment to, and shall be protected in relying upon,
the Officers’ Certificate that the Company is obligated to deliver to the Trustee pursuant to Section 4.05(k). The Trustee makes no representation as to the validity or value of any securities or assets issued upon conversion of
Securities, and the Trustee shall not be responsible for the Company’s failure to comply with any provisions of this Article 4. The Trustee and the Conversion Agent (if other than the Trustee) shall have no responsibility for determination of
the Daily Settlement Amounts (if applicable) or the Daily Conversion Values (if applicable). In addition, in no event shall the Trustee or Conversion Agent be responsible for making any calculations under this Indenture or for determining amounts to
be paid or for monitoring any Stock Price. For the avoidance of 

  
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doubt, the Trustee and the Conversion Agent shall rely conclusively on the calculations and information provided to them by the Company as to the Daily VWAP, Trading Price, Daily Conversion
Value, Daily Settlement Amount and Last Reported Sale Price. Neither the Trustee nor the Conversion Agent shall be charged with knowledge of or have any duties to monitor any Measurement Period or Observation Period or determine whether the
Securities are convertible or to notify the Company, the Holders or the Depositary if the Securities have become convertible, or whether any Merger Event has occurred, or whether any adjustments to the Conversion Rate are required. The rights,
privileges, protections, immunities and benefits given to the Trustee, including without limitation its right to be compensated, reimbursed and indemnified, are extended to, and shall be enforceable by, the Trustee in each of its capacities
hereunder, including its capacity as Conversion Agent and as Bid Solicitation Agent (if applicable). 
 The Trustee shall not be under any
responsibility to determine the correctness of any provisions contained in any supplemental indenture executed pursuant to Section 10.01, but may accept as conclusive evidence of the correctness thereof, and shall be fully protected in relying
upon, the Officers’ Certificate with respect thereto which the Company is obligated to file with the Trustee pursuant to Section 10.06. 

Section 4.11. Exchange in Lieu of Conversion. (a) When a Holder surrenders Securities for conversion, the Company may, at its
election, direct the Conversion Agent to surrender, on or prior to the Scheduled Trading Day immediately preceding the first Trading Day of the applicable Observation Period (or, if the Company has elected Physical Settlement, on or prior to the
Business Day immediately following the relevant Conversion Date), such Securities to a financial institution designated by the Company for exchange in lieu of conversion (each, an “Exchange in Lieu of Conversion”). In order to
accept any Securities surrendered for conversion, the designated financial institution must agree to pay and/or deliver, as the case may be, in exchange for such Securities, all of the cash, shares of Common Stock or a combination thereof due upon
conversion, all in accordance with Section 4.02. By the close of business on the Scheduled Trading Day immediately preceding the first Trading Day of the applicable Observation Period (or, if the Company has elected Physical Settlement, by the
close of business on the Business Day immediately following the relevant Conversion Date), the Company shall notify in writing the Holder surrendering Securities for conversion, the Trustee and the Conversion Agent that the Company has directed the
designated financial institution to make an Exchange in Lieu of Conversion. 
 (b) If the designated financial institution accepts any such
Securities, it shall pay and/or deliver, as the case may be, the cash, shares of Common Stock or a combination thereof due upon conversion to the Conversion Agent or such Holder, and the Conversion Agent shall pay and/or deliver such cash and/or
shares of Common Stock to such Holder on the second Business Day immediately following the last Trading Day of the applicable Observation Period (or, if the Company has elected Physical Settlement, on the second Business Day immediately following
the relevant Conversion Date). Any Securities exchanged by the designated institution shall remain outstanding, subject to the Applicable Procedures. If the designated financial institution agrees to accept any Securities for exchange but does not
timely pay and/or deliver the related cash, shares of Common Stock or a combination thereof, as the case may be, or if such designated financial institution does not accept the Securities for exchange, the Company shall


  
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convert the Securities and pay and/or deliver, as the case may be, the cash, shares of Common Stock or a combination thereof due upon conversion on the second Business Day immediately following
the last Trading Day of the applicable Observation Period (or, if the Company has elected Physical Settlement, on the second Business Day immediately following the relevant Conversion Date) in accordance with Section 4.02. 

(c) The Company’s designation of a financial institution to which the Securities may be submitted for exchange does not require the
financial institution to accept any Securities (unless the financial institution has separately made an agreement with the Company). The Company may, but shall not be obligated to, enter into a separate agreement with any designated financial
institution that would compensate the designated financial institution for any such transaction. The Company shall comply, and cause any designated financial institution to comply, with the Applicable Procedures. 

ARTICLE 5 
 COVENANTS

 Section 5.01. Payment on the Securities. The Company shall promptly make all payments in respect of the Securities on the
dates and in the manner provided in the Securities and this Indenture. Principal (including the Redemption Price and Fundamental Change Repurchase Price, if applicable) of and interest on the Securities shall be considered paid on the date it is
due, if the Paying Agent (if other than the Company or an Affiliate thereof) holds as of 12:00 p.m., New York City time, on the due date money, deposited by the Company or an Affiliate thereof in immediately available funds, designated for and
sufficient to pay all principal (including the Redemption Price and the Fundamental Change Repurchase Price, if applicable) and interest then due on the Securities. 

Payment of the principal of and interest on the Securities shall be made at the office or agency of the Company maintained for that purpose
(which shall initially be the Corporate Trust Office of the Trustee); provided, however, that at the option of the Company payment of interest may be made by check mailed to the address of the Person entitled thereto as such address appears
in the Register; provided, further that a Holder with an aggregate principal amount in excess of $2,000,000 will be paid by wire transfer to an account within the United States in immediately available funds at the election of such Holder if
such Holder has provided wire transfer instructions to the Company and the Trustee at least ten Business Days prior to the payment date, it being understood that as long as the Securities are Global Securities, payment will be made by wire transfer
to DTC. 
 Section 5.02. SEC Reports and Rule 144A Information Requirement. 

(a) The Company shall file with the Trustee within 15 days after the same are required to be filed with the SEC, copies of any documents or
reports that the Company is required to file with the SEC pursuant to Section 13 or 15(d) of the Exchange Act (giving effect to any grace period provided by Rule 12b-25 under the Exchange Act). Any such
document or report that the Company files with the SEC via the EDGAR system shall be deemed to be filed with the Trustee for purposes of this Section 5.02 at the time such documents are filed via EDGAR, though the Trustee shall have no
obligation to determine whether such filings have been made or the contents therein. 

  
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 (b) Delivery of such reports, information and documents to the Trustee is for informational
purposes only and the Trustee’s receipt of such shall not constitute constructive notice of any information contained therein or determinable from information contained therein, including the Company’s compliance with any of its covenants
hereunder (as to which the Trustee is entitled to rely exclusively on an Officers’ Certificate). The Trustee shall have no obligation whatsoever to monitor or determine, on a continuing basis or otherwise, whether or not such information,
documents or reports have been filed pursuant to the EDGAR system or postings to any website have occurred. 
 (c) At any time the Company is
not subject to Section 13 or 15(d) of the Exchange Act, the Company shall, so long as any of the Securities or any shares of Common Stock issuable upon conversion thereof shall, at such time, constitute “restricted securities” within
the meaning of Rule 144(a)(3) under the Securities Act, promptly provide to the Trustee and, upon written request, any Holder, beneficial owner or prospective purchaser of such Securities or any shares of Common Stock issuable upon conversion of
such Securities, the information required to be delivered pursuant to Rule 144A(d)(4) under the Securities Act to facilitate the resale of such Securities or shares of Common Stock pursuant to Rule 144A. 

(d) If, at any time during the six-month period beginning on, and including, the date that is six
months after the last date of original issuance of the Securities, the Company fails to timely file any document or report that it is required to file with the Commission pursuant to Section 13 or 15(d) of the Exchange Act, as applicable (after
giving effect to all applicable grace periods thereunder and other than Current Reports on Form 8-K), or the Securities are not otherwise freely tradable pursuant to Rule 144 by Holders other than the
Company’s Affiliates or Holders that were the Company’s Affiliates at any time during the three months preceding (as a result of restrictions pursuant to U.S. securities laws or the terms of this Indenture or the Securities), the Company
shall pay Additional Interest on the Securities. Such Additional Interest shall accrue on the Securities at the rate of 0.50% per annum of the principal amount of the Securities outstanding for each day during which the Company’s failure to
file has occurred and is continuing or the Securities are not otherwise freely tradable as described above by Holders other than the Company’s Affiliates (or Holders that have been the Company’s Affiliates at any time during the three
months preceding). As used in this Section 5.02(d), documents or reports that the Company is required to “file” with the Commission pursuant to Section 13 or 15(d) of the Exchange Act do not include documents or reports that the
Company furnishes to the Commission pursuant to Section 13 or 15(d) of the Exchange Act. 
 (e) If, and for so long as, the restrictive
legend on the Securities specified in Section 2.06(d) has not been removed, the Securities are assigned a restricted CUSIP or the Securities are not otherwise freely tradable pursuant to Rule 144 by Holders other than the Company’s
Affiliates or Holders that were the Company’s Affiliates at any time during the three months preceding (without restrictions pursuant to U.S. securities laws or the terms of this Indenture or the Securities) as of the 380th day after the last
date of original issuance of the Securities, the Company shall pay Additional Interest on the Securities at a rate equal to 0.50% per annum of the principal amount of Securities outstanding until the restrictive legend on the Securities has been
removed, the Securities are assigned an unrestricted CUSIP and the Securities are freely tradable as described above by Holders other than the Company’s Affiliates (or Holders that were the Company’s Affiliates at any time during the three
months preceding). 

  
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 (f) Additional Interest will be payable in arrears on each Interest Payment Date following
accrual in the same manner as regular interest on the Securities. 
 (g) The Additional Interest that is payable in accordance with
Section 5.02(d) or Section 5.02(e) shall be in addition to, and not in lieu of, any Additional Interest that may be payable as a result of the Company’s election pursuant to Section 7.04. However, in no event shall the Additional
Interest that may accrue as a result of the Company’s failure to timely file any document or report that the Company is required to file with the Commission pursuant to Section 13 or 15(d) of the Exchange Act, as applicable, as set forth
in Section 5.02(d), together with any Additional Interest that may accrue in the event the Company elects to pay Additional Interest in respect of an Event of Default relating to its failure to comply with its obligations as set forth in
Section 5.02(a), as provided in Section 7.04, accrue at a rate in excess of 0.50% per annum pursuant to this Indenture, regardless of the number of events or circumstances giving rise to the requirement to pay such Additional Interest.

 (h) If Additional Interest is payable by the Company pursuant to Section 5.02(d), Section 5.02(e) or Section 7.04, the
Company shall deliver to the Trustee and the Paying Agent, prior to the time such Additional Interest is payable, an Officers’ Certificate to that effect stating (i) the amount of such Additional Interest that is payable in reasonable
detail and (ii) the date on which such Additional Interest is payable. Unless and until a Responsible Officer of the Trustee receives at the Corporate Trust Office such a certificate, the Trustee may assume without inquiry that no such
Additional Interest is payable. Neither the Trustee nor the Paying Agent shall have any responsibility or liability for the determination, verification or calculation of any Additional Interest. If the Company has paid Additional Interest directly
to the Persons entitled to it, the Company shall deliver to the Trustee an Officers’ Certificate setting forth the particulars of such payment. 

Section 5.03. Compliance Certificates. 

(a) The Company shall deliver to the Trustee within 120 days after the end of each fiscal year during which any Securities were outstanding an
Officers’ Certificate (that need not comply with Section 11.04(b)) stating whether or not the signers thereof know of any Default or Event of Default that occurred during such fiscal year and that the Company has complied with all
conditions and covenants under this Indenture. For purposes of this Section 5.03, such compliance shall be determined without regard to any period of grace or requirement of notice provided under this Indenture. If the Officers of the Company
signing such Officers’ Certificate have knowledge of such a Default or Event of Default, the Officers’ Certificate shall describe any such Default or Event of Default and its status. 

(b) The Company shall, so long as any of the Securities are outstanding, deliver to the Trustee in writing, forthwith, and in any event within
five Business Days, after any Officer becoming aware of the occurrence of any Default or Event of Default, an Officers’ Certificate specifying such Default or Event of Default and what action the Company is taking or proposes to take with
respect thereto. 

  
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 Section 5.04. Further Instruments and Acts. Upon request of the Trustee, the
Company will execute and deliver such further instruments and do such further acts as may be reasonably necessary or proper to carry out more effectively the purposes of this Indenture. 

Section 5.05. Maintenance of Corporate Existence. Subject to Article 6, the Company will do or cause to be done all things
necessary to preserve and keep in full force and effect its corporate existence. 
 Section 5.06. Stay, Extension and Usury
Laws. The Company covenants (to the extent that it may lawfully do so) that it shall not at any time insist upon, plead, or in any manner whatsoever claim or take the benefit or advantage of, any stay, extension or usury law or other law which
would prohibit or forgive the Company from paying all or any portion of the principal of or interest on the Securities as contemplated herein, wherever enacted, now or at any time hereafter in force, or which may affect the covenants or the
performance of this Indenture, and the Company (to the extent it may lawfully do so) hereby expressly waives all benefit or advantage of any such law and covenants that it will not, by resort to any such law, hinder, delay or impede the execution of
any power herein granted to the Trustee, but will suffer and permit the execution of every such power as though no such law had been enacted. 

ARTICLE 6 

CONSOLIDATION, MERGER, SALE, CONVEYANCE, TRANSFER OR LEASE 

Section 6.01. Company May Consolidate, Etc., Only on Certain Terms. The Company shall not, directly or indirectly, in a
single transaction or a series of transactions, consolidate with or merge into any other Person or sell, convey, transfer or lease all or substantially all of its properties and assets to another Person, unless: 

(a) either (i) the Company is the continuing Person or (ii) the resulting, successor or transferee Person, if not the Company (such
Person, the “Successor Company”), is a corporation organized and existing under the laws of the United States, any State of the United States, or the District of Columbia; 

(b) such Person (if other than the Company) expressly assumes by an indenture supplemental hereto, executed and delivered to the Trustee, in
form satisfactory to the Trustee, the due and punctual payment of the principal of and interest on all the Securities and the performance or observance of every covenant of this Indenture on the part of the Company to be performed or observed and
the conversion rights provided for in accordance with Article 4; 
 (c) immediately after giving effect to such transaction, no Event of
Default, and no event which, after notice or lapse of time or both, would become an Event of Default, shall have occurred and be continuing; 

  
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 (d) if as a result of such transaction the Securities become convertible into common stock
or other securities issued by a third party, such third party fully and unconditionally guarantees all of the obligations of the Company or such Successor Company under the Securities and this Indenture; and 

(e) the Company has delivered to the Trustee an Officers’ Certificate and an Opinion of Counsel, each stating that such consolidation,
merger, sale, conveyance, transfer or lease and, if a supplemental indenture is required in connection with such transaction, such supplemental indenture, comply with this Article 6 and that all conditions precedent herein provided for relating to
such transaction have been complied with. 
 Section 6.02. Successor Substituted. Upon any consolidation of the Company with, or
merger of the Company into, any other Person or any sale, conveyance, transfer or lease of all or substantially all of the properties and assets of the Company in accordance with Section 6.01 in which the Company is not the continuing
corporation, there shall be an adjustment to the Conversion Rate and the Successor Company shall succeed to, and be substituted for, and may exercise every right and power of, the Company under this Indenture with the same effect as if such
Successor Company had been named as the Company herein, and thereafter, except in the case of a lease, the Company shall be relieved of all obligations and covenants under this Indenture and the Securities. 

ARTICLE 7 
 DEFAULT AND
REMEDIES 
 Section 7.01. Events of Default. An “Event of Default” shall occur if: 

(1) the Company fails to pay the principal of any Security when due and payable at its stated maturity, upon Optional Redemption, upon any
required repurchase, upon declaration of acceleration or otherwise; 
 (2) the Company fails to pay the interest on any Security when due and
payable and such failure continues for a period of 30 days; 
 (3) the Company fails to convert any Security in accordance with this
Indenture upon exercise of a Holder’s conversion right for a period of three Business Days; 
 (4) the Company fails to provide timely
notice pursuant to Section 3.05(b), Section 4.01(e), Section 4.01(f) or Section 4.04(b), in each case when due; 
 (5)
the Company fails to comply with its obligations set forth in Article 6; 
 (6) the Company fails to perform any other agreement required of
it in this Indenture or the Securities and such failure continues for 60 days after written notice is given in accordance with the immediately succeeding paragraph; 

  
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 (7) any indebtedness for money borrowed by the Company or any of its Significant
Subsidiaries in an aggregate outstanding principal amount in excess of $50,000,000 (or its foreign currency equivalent) is not paid at final maturity or upon acceleration, and such indebtedness is not discharged, or such acceleration is not cured or
rescinded, within 30 days after written notice is given in accordance with the immediately succeeding paragraph; 
 (8) the Company or any
Significant Subsidiary, pursuant to or within the meaning of any Bankruptcy Law: 
 (A) commences a voluntary case or
proceeding; 
 (B) consents to the entry of an order for relief against it in an involuntary case or proceeding; 

(C) consents to the appointment of a Custodian of it or for all or substantially all of its property; or 

(D) makes a general assignment for the benefit of its creditors; or 

(9) a court of competent jurisdiction enters an order or decree under any Bankruptcy Law that: 

(A) is for relief against the Company or any Significant Subsidiary in an involuntary case or proceeding; 

(B) appoints a Custodian of the Company or any Significant Subsidiary or for all or substantially all of the property of the
Company or any Significant Subsidiary; or 
 (C) orders the liquidation of the Company or any Significant Subsidiary; 

and in each case the order or decree remains unstayed and in effect for 60 consecutive days. 

The notice given pursuant to this Section 7.01 may be given by written notice to the Company by the Trustee or by notice to the Company
and the Trustee by the Holders of at least 25% in aggregate principal amount of the Securities then outstanding (with a copy to the Trustee) and must specify the default, demand that it be remedied and state that the notice is a “Notice of
Default.” When any default under this Section 7.01 is cured, it ceases. 
 Section 7.02. Acceleration. If an Event
of Default (other than an Event of Default specified in clause (8) or (9) of Section 7.01 with respect to the Company (and not a Significant Subsidiary of the Company)) occurs and is continuing, the Trustee may, by notice to the Company,
or the Holders of at least 25% in aggregate principal amount of the Securities then outstanding may, by notice to the Company and the Trustee, declare all unpaid principal to the date of acceleration on the Securities then outstanding (if not then
due and payable) to be due and payable upon any such declaration, and the same shall become and be immediately due and payable. If an Event of Default specified in clause (8) or (9) of Section 7.01 occurs with respect to the Company (and
not a Significant Subsidiary), all unpaid principal of the Securities then outstanding shall ipso facto become and be immediately due and payable without any declaration 

  
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or other act on the part of the Trustee or any Holder. After any acceleration, but before a judgment or decree based on acceleration, the Holders of a majority in aggregate principal amount of
the Securities may, except with respect to the nonpayment of principal (including the Redemption Price and the Fundamental Change Repurchase Price, if applicable) or interest or with respect to the failure to pay and/or deliver the consideration due
upon conversion, rescind and annul such acceleration by notice to the Trustee if (a) all existing Events of Default, other than the nonpayment of accelerated principal, have been cured or waived; (b) to the extent the payment of such
interest is lawful, interest (calculated at the rate per annum borne by the Securities) on overdue installments of interest and overdue principal, which has become due otherwise than by such declaration of acceleration, has been paid; (c) the
rescission would not conflict with any judgment or decree of a court of competent jurisdiction; and (d) all payments due to the Trustee and any predecessor Trustee under Section 8.07 have been made. No such rescission shall affect any
subsequent default or impair any right consequent thereto. 
 Section 7.03. Other Remedies. If an Event of Default occurs and is
continuing, the Trustee may, but shall not be obligated to, pursue any available remedy by proceeding at law or in equity to collect the payment of the principal of or interest on the Securities or to enforce the performance of any provision of the
Securities or this Indenture. 
 The Trustee may maintain a proceeding even if it does not possess any of the Securities or does not produce
any of them in the proceeding. A delay or omission by the Trustee or any Holder in exercising any right or remedy accruing upon an Event of Default shall not impair the right or remedy or constitute a waiver of or acquiescence in the Event of
Default. No remedy is exclusive of any other remedy. All available remedies are cumulative to the extent permitted by law. If the Trustee or any Holder has instituted any proceeding to enforce any right or remedy under this Indenture and such
proceeding has been discontinued or abandoned for any reason, or has been determined adversely to the Trustee or to such Holder, then and in every such case, subject to any determination in such proceedings, the Company, the Trustee and the Holders
shall be restored severally and respectively to their former positions hereunder and thereafter all rights and remedies of the Trustee and the Holders shall continue as though no such proceeding has been instituted. 

Section 7.04. Additional Interest. (a) Notwithstanding anything in this Indenture or in the Securities to the contrary, to
the extent the Company elects, the sole remedy for an Event of Default during the first 360 days after the occurrence of an Event of Default (which, for the avoidance of doubt, shall not commence until the notice set forth in clause (6) of
Section 7.01 has been given, and the related 60-day period set forth in clause (6) of Section 7.01 has passed) relating to the Company’s failure to comply with its obligations as set forth
in Section 5.02(a), shall after the occurrence of such an Event of Default consist exclusively of the right to receive Additional Interest on the Securities, at a rate equal to (i) for the first 180 days after the occurrence of such an
Event of Default, 0.25% per annum of the principal amount of the Securities outstanding for each day during which such Event of Default is continuing during such period, beginning on, and including, the date on which such an Event of Default first
occurs, and (ii) for the 180 days from and after the 181st day after the occurrence of such an Event of Default, 0.50% per annum of the principal amount of the Securities outstanding for each day during which such Event of Default is continuing
during such period. Additional Interest payable pursuant to this Section 7.04 shall be in addition to, not in lieu of, any Additional Interest payable pursuant to Section 5.02(d) or Section 5.02(e), subject to Section 7.04(c).


  
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 (b) If the Company so elects, such Additional Interest shall be payable in the same manner
and on the same dates as the stated interest payable on the Securities. On the 361st day after such Event of Default (if such Event of Default is not cured or waived prior to such 361st day, and which period shall not commence until expiration of
the 60-day period set forth in clause (6) of Section 7.01), the Securities will be subject to acceleration as provided in Section 7.02. This Section 7.04 shall not affect the rights of
Holders in the event of the occurrence of any other Event of Default. If the Company does not elect to pay Additional Interest following an Event of Default in accordance with this Section 7.04, or if it so elects but fails to pay the
Additional Interest when due, the Securities shall be immediately subject to acceleration as provided in Section 7.02. To elect to pay Additional Interest as the sole remedy during the first 360 days after the occurrence of an Event of Default
relating to the failure to comply with the reporting obligations in accordance with subsection (a) of this Section 7.04 and this subsection (b), the Company must notify in writing all Holders of the Securities, the Trustee and the Paying
Agent of such election prior to the beginning of such 360-day period. Upon the Company’s failure to timely give such notice or if the Company gives such notice but does not pay the Additional Interest
when due, the Securities shall be immediately subject to acceleration as provided in Section 7.02. 
 (c) In no event shall the
Additional Interest described in this Section 7.04, together with any Additional Interest that may accrue as a result of the Company’s failure to timely file any document or report that the Company is required to file with the Commission
pursuant to Section 13 or 15(d) of the Exchange Act, as applicable, as provided in Section 5.02(d), accrue at a rate in excess of 0.50% per annum pursuant to this Indenture, regardless of the number of events or circumstances giving rise
to the requirement to pay such Additional Interest. 
 Section 7.05. Waiver of Defaults and Events of Default. Subject to
Section 7.08 and Section 10.02, the Holders of a majority in aggregate principal amount of the Securities then outstanding by notice to the Trustee may waive an existing default or Event of Default and its consequence, except (a) a
default or Event of Default in the payment of the principal (including the Redemption Price and the Fundamental Change Repurchase Price, if applicable) of or interest on any Security, (b) a failure by the Company to convert any Securities in
accordance with the provisions of the Securities and this Indenture or (c) any default or Event of Default in respect of any provision of this Indenture or the Securities that, under Section 10.02, cannot be modified or amended without the
consent of the Holder of each Security affected. When a default or Event of Default is waived, it is cured and ceases. 
 Section 7.06.
Control by Majority. The Holders of a majority in aggregate principal amount of the outstanding Securities will have the right to direct the time, method and place of conducting any proceeding for any remedy available to the Trustee or
exercising any trust or power conferred on the Trustee with respect to the Securities. However, the Trustee may refuse to follow any direction that it determines is unduly prejudicial to the rights of any other Holder (it being agreed that the
Trustee shall have no obligation to determine whether such direction is prejudicial to any Holder) or that violates law or this Indenture or that would result in the Trustee incurring personal liability; provided, however, that the
Trustee may take any other action deemed proper by the Trustee that is not inconsistent with such direction. 

  
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 Section 7.07. Limitations on Suits. A Holder may not pursue any remedy with
respect to this Indenture or the Securities (except actions for the enforcement of payment of the principal (including the Redemption Price and the Fundamental Change Repurchase Price, if applicable) or interest on any Security on or after the
applicable due date or the right to convert the Securities or to receive the consideration due upon such conversion in accordance with Article 4) unless: 

(1) the Holder has previously given the Trustee written notice of a continuing Event of Default; 

(2) the Holders of at least 25% in aggregate principal amount of the Securities then outstanding have made a written request and have offered
to the Trustee security or indemnity reasonably satisfactory to the Trustee against loss, cost, liability or expense to institute such proceeding as Trustee; and 

(3) the Trustee has failed to institute such proceeding within 60 days after such notice, request and offer, and has not received from the
Holders of a majority in aggregate principal amount of the Securities then outstanding a direction inconsistent with such request within 60 days after such notice, request and offer. 

A Holder may not use this Indenture to prejudice the rights of another Holder or to obtain a preference or priority over such other Holder.

 Section 7.08. Rights of Holders to Receive Payment and to Convert. Each Holder shall have the right to receive payment or
delivery, as the case may be, of (a) the principal (including the Redemption Price and the Fundamental Change Repurchase Price, if applicable) of, (b) accrued and unpaid interest, if any, on, and (c) the consideration due upon
conversion of, its Securities, on or after the respective due dates expressed or provided for in this Indenture, or to institute suit for the enforcement of any such payment or delivery, as the case may be, and such right to receive payment or
delivery, as the case may be, on or after such respective dates shall not be impaired or affected without the consent of such Holder. 

Section 7.09. Collection Suit by Trustee. If an Event of Default in the payment of principal or interest specified in clause
(1) or (2) of Section 7.01 occurs and is continuing, the Trustee may recover judgment in its own name and as trustee of an express trust against the Company or another obligor on the Securities for the whole amount of principal and accrued
interest remaining unpaid, together with, to the extent that payment of such interest is lawful, interest on overdue principal and on overdue installments of interest, in each case at the rate per annum borne by the Securities and such further
amount as shall be sufficient to cover the costs and expenses of collection, including the reasonable compensation, expenses, disbursements and advances of the Trustee, its agents and counsel. 

  
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 Section 7.10. Trustee May File Proofs of Claim. The Trustee may file such proofs
of claim and other papers or documents as may be necessary or advisable in order to have the claims of the Trustee (including any claim for the reasonable compensation, expenses, disbursements and advances of the Trustee, its agents and counsel) and
the Holders allowed in any judicial proceedings relative to the Company (or any other obligor on the Securities), its creditors or its property and shall be entitled and empowered to collect and receive any money or other property payable or
deliverable on any such claims and to distribute the same, and any Custodian in any such judicial proceeding is hereby authorized by each Holder to make such payments to the Trustee and, in the event that the Trustee shall consent to the making of
such payments directly to the Holders, to pay to the Trustee any amount due to it for the reasonable compensation, expenses, disbursements and advances of the Trustee, its agents and counsel, and any other amounts due the Trustee under
Section 8.07, and to the extent that such payment of the reasonable compensation, expenses, disbursements and advances in any such proceedings shall be denied for any reason, payment of the same shall be secured by a lien on, and shall be paid
out of, any and all distributions, dividends, money, securities and other property which the Holders may be entitled to receive in such proceedings, whether in liquidation or under any plan of reorganization or arrangement or otherwise. Nothing
herein contained shall be deemed to authorize the Trustee to authorize or consent to, or, on behalf of any Holder, to authorize, accept or adopt any plan of reorganization, arrangement, adjustment or composition affecting the Securities or the
rights of any Holder thereof, or to authorize the Trustee to vote in respect of the claim of any Holder in any such proceeding. 

Section 7.11. Priorities. If the Trustee collects any money or property pursuant to this Article 7, or after an Event of Default
any moneys or properties are distributable in respect of the Company’s obligations under this Indenture, the money or property shall be paid out or distributed in the following order: 

FIRST, to the Trustee for amounts due under Section 8.07; 

SECOND, in case the principal of the outstanding Securities shall not have become due and be unpaid, to the payment of interest on, and any
cash due upon conversion of, the Securities in default in the order of the date due of the payments of such interest and cash due upon conversion, as the case may be, with interest (to the extent that such interest has been collected by the Trustee)
upon such overdue payments at the rate borne by the Securities at such time, such payments to be made ratably to the Persons entitled thereto; 

THIRD, in case the principal of the outstanding Securities shall have become due, by declaration or otherwise, and be unpaid, to the payment
of the whole amount (including, if applicable, the payment of the Redemption Price and the Fundamental Change Repurchase Price and any cash due upon conversion) then owing and unpaid upon the Securities for principal and interest, if any, with
interest on the overdue principal and, to the extent that such interest has been collected by the Trustee, upon overdue installments of interest at the rate borne by the Securities at such time, and in case such monies shall be insufficient to pay
in full the whole amounts so due and unpaid upon the Securities, then to the payment of such principal (including, if applicable, the Redemption Price and the Fundamental Change Repurchase Price and any cash due upon conversion) and interest without
preference or priority of principal over interest, or of interest over principal or of any installment of interest over any other installment of interest, or of any Security over any other Security, ratably to the aggregate of such principal
(including, if applicable, the Redemption Price and the Fundamental Change Repurchase Price and any cash due upon conversion) and accrued and unpaid interest; and 

  
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 FOURTH, to the Company or such party as a court of competent jurisdiction shall direct. 

The Trustee may fix a record date and payment date for any payment to Holders pursuant to this Section 7.11. 

Section 7.12. Undertaking for Costs. In any suit for the enforcement of any right or remedy under this Indenture or in any suit
against the Trustee for any action taken or omitted by it as Trustee, a court in its discretion may require the filing by any party litigant in the suit of an undertaking to pay the costs of the suit, and the court in its discretion may assess
reasonable costs, including reasonable attorneys’ fees and expenses, against any party litigant in the suit, having due regard to the merits and good faith of the claims or defenses made by the party litigant. This Section 7.12 does not
apply to a suit made by the Trustee, a suit by a Holder pursuant to Section 7.07, or a suit by Holders of more than 10% in aggregate principal amount of the Securities then outstanding. 

ARTICLE 8 
 TRUSTEE

 Section 8.01. Duties of Trustee. (a) If an Event of Default has occurred and is continuing, the Trustee shall
exercise such of the rights and powers vested in it by this Indenture and use the same degree of care and skill in their exercise as a prudent Person would exercise or use under the circumstances in the conduct of his or her own affairs. 

(b) Except during the continuance of an Event of Default: 

(i) the duties of the Trustee shall be determined solely by the express provisions of this Indenture and the Trustee need
perform only those duties that are specifically set forth in this Indenture and no others, and no implied covenants or obligations shall be read into this Indenture against the Trustee; and 

(ii) in the absence of bad faith on its part, the Trustee may conclusively rely, as to the truth of the statements and the
correctness of the opinions expressed therein, upon certificates or opinions furnished to the Trustee and conforming to the requirements of this Indenture. The Trustee, however, shall examine any certificates and opinions which by any provision
hereof are specifically required to be delivered to the Trustee to determine whether or not they conform to the requirements of this Indenture (but need not confirm or investigate the accuracy of mathematical calculations or other facts stated
therein). 
 (c) The Trustee may not be relieved from liability for its own negligent action, its own negligent failure to act, or its own
willful misconduct, except that: 
 (i) this paragraph does not limit the effect of subsection (b) of this
Section 8.01; 

  
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 (ii) the Trustee shall not be liable for any error of judgment made in good
faith by a Responsible Officer, unless it is proved that the Trustee was negligent in ascertaining the pertinent facts; and 

(iii) the Trustee shall not be liable with respect to any action it takes or omits to take in good faith in accordance with a
direction received by it pursuant to Section 7.06. 
 (d) No provision of this Indenture shall require the Trustee to expend or risk its
own funds or incur any liability in performing its duties or in the exercise of any rights or powers. The Trustee shall be under no obligation to exercise any of the rights or powers vested in it by this Indenture at the request or direction of any
of the Holders pursuant to this Indenture, unless such Holders shall have offered and, if requested, provided to the Trustee security or indemnity satisfactory to the Trustee against the costs, losses, expenses and liabilities that might be incurred
by it in compliance with such request or direction. The Trustee shall not be required to give any bond or surety in respect of the performance of its powers or duties hereunder. 

(e) Every provision of this Indenture that in any way relates to the Trustee is subject to subsections (a), (b), (c) and (d) of this
Section 8.01. 
 (f) The Trustee shall not be liable for interest on any money received by it except as the Trustee may agree in writing
with the Company. Money and other property held in trust by the Trustee need not be segregated from other funds except to the extent required by law. 

Section 8.02. Rights of Trustee. Subject to Section 8.01: 

(a) The Trustee may rely conclusively on any document (whether in its original or facsimile form) believed by it to be genuine and to have been
signed or presented by the proper Person. The Trustee need not investigate any fact or matter stated in the document. 
 (b) Before the
Trustee acts or refrains from acting, it may require an Officers’ Certificate and an Opinion of Counsel, which shall conform to Section 11.04(b). The Trustee shall not be liable for any action it takes or omits to take in good faith in
reliance on such Officers’ Certificate or Opinion of Counsel. 
 (c) The Trustee may act through its agents and shall not be responsible
for the misconduct or negligence of any agent appointed with due care. 
 (d) The Trustee shall not be liable for any action it takes or
omits to take in good faith which it believes to be authorized or within its rights or powers conferred upon it by this Indenture. 
 (e) The
Trustee may consult with counsel of its selection, and the written or verbal advice or opinion of such counsel as to matters of law shall be full and complete authorization and protection from liability in respect of any such action taken, omitted
or suffered by it hereunder in good faith and in accordance with the advice or opinion of such counsel. 

  
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 (f) The Trustee shall not be bound to make any investigation into the facts or matters
stated in any resolution, certificate, statement, instrument, opinion, report, notice, request, direction, consent, order, bond, debenture, note, other evidence of indebtedness or other paper or document, but the Trustee, in its discretion, may make
such further inquiry or investigation into such facts or matters as it may see fit, and, if the Trustee shall determine to make such further inquiry or investigation, it shall be entitled to examine the books, records and premises of the Company,
personally or by agent or attorney at the sole cost of the Company and shall incur no liability or additional liability of any kind by reason of such inquiry or investigation. 

(g) The Trustee shall not be charged with knowledge of any Default or Event of Default unless written notice thereof shall have been actually
received by a Responsible Officer at the Corporate Trust Office of the Trustee from the Company, a Paying Agent, any Holder or any agent of any Holder. 

(h) The rights, privileges, protections, immunities and benefits given to the Trustee, including, without limitation, its right to be
compensated, reimbursed and indemnified, are extended to, and shall be enforceable by, the Trustee in each of its capacities hereunder, and to each agent, custodian and other Person employed to act hereunder. 

(i) The Trustee may request that the Company deliver an Officers’ Certificate setting forth the names of individuals and/or titles of
Officers authorized at such time to take specified actions pursuant to this Indenture, which Officers’ Certificate may be signed by any Person authorized to sign an Officers’ Certificate, including any Person specified as so authorized in
any such certificate previously delivered and not superseded. 
 (j) In no event shall the Trustee be responsible or liable for special,
punitive, indirect or consequential loss or damage of any kind whatsoever (including, but not limited to, loss of profit) irrespective of whether the Trustee has been advised of the likelihood of such loss or damage and regardless of the form of
action. 
 (k) The permissive rights or powers of the Trustee to do things enumerated in this Indenture shall not be construed as a duty of
the Trustee. 
 (l) In connection with any proposed exchange of a certificated Security for a Global Security, the Company shall be required
to use reasonable efforts to provide or cause to be provided to the Trustee all information within its possession that is requested by the Trustee and necessary to allow the Trustee to comply with any applicable tax reporting obligations, including
without limitation any cost basis reporting obligations under Section 6045 of the Internal Revenue Code. The Trustee may rely on information provided to it and shall have no responsibility to verify or ensure the accuracy of such information.

 Section 8.03. Individual Rights of Trustee. The Trustee in its individual or any other capacity may become the owner or
pledgee of Securities and may become a creditor of, or otherwise deal with, the Company or any of its Affiliates with the same rights it would have if it were not Trustee. Any Agent may do the same with like rights and duties. 

  
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 Section 8.04. Trustee’s Disclaimer. The Trustee shall not be
responsible for and makes no representation as to the validity, priority or adequacy of this Indenture or the Securities or the Common Stock, it shall not be accountable for the Company’s use of the proceeds from the Securities or any money
paid to the Company or upon the Company’s direction under any provision of this Indenture, it shall not be responsible for the use or application of any money received by any Paying Agent (other than the Trustee) and it shall not be responsible
for any statement or recital herein or any statement in the Securities or in the offering memorandum relating to the offer and sale of the Securities or any other document in connection with the sale of the Securities or pursuant to this Indenture
other than its certificate of authentication. Under no circumstances shall the Trustee be liable in its individual capacity for the obligations evidenced by the Securities. The Trustee shall not be bound to ascertain or inquire as to the
performance, observance or breach of any covenants, conditions, representations, warranties or agreements on the part of the Company but the Trustee may require full information and advice as to the performance of the aforementioned covenants. The
Trustee (including in each of its capacities hereunder) shall have no obligations to independently determine or verify if any Fundamental Change, Make-Whole Fundamental Change, Merger Event or any other event has occurred or notify the Holders of
any such event. The Trustee (including in each of its capacities hereunder) shall have no responsibility for any act or omission of any financial institution the Company designates in connection with any Exchange in Lieu of Conversion. 

Section 8.05. Notice of Default or Events of Default. If a Default or an Event of Default occurs and is continuing and if it is
actually known to a Responsible Officer of the Trustee in accordance with the terms of this Indenture, the Trustee shall mail to each Holder notice of the Default or Event of Default within 90 days after it receives notice thereof. However, the
Trustee may withhold the notice if and so long as the Trustee in good faith determines that withholding notice is in the interests of Holders, except in the case of a Default or an Event of Default in (a) payment of the principal of (including
the Redemption Price and the Fundamental Change Repurchase Price, if applicable) or interest on any Security or (b) payment or delivery, as the case may be, of the consideration due upon conversion. 

Section 8.06. [Reserved]. 

Section 8.07. Compensation and Indemnity. The Company shall pay to the Trustee, in each of its capacities hereunder, from time to
time such compensation (as agreed to from time to time by the Company and the Trustee in writing) for its services (which compensation shall not be limited by any provision of law in regard to the compensation of a trustee of an express trust). The
Company shall reimburse the Trustee promptly upon request for all reasonable disbursements, expenses and advances reasonably incurred or made by it in addition to the compensation for its services. Such expenses may include the reasonable
compensation, disbursements and expenses of the Trustee’s agents and counsel. 
 The Company shall indemnify each of the Trustee and
any predecessor Trustee against any and all losses, liabilities, damages, claims or expenses (including taxes, other than taxes based upon, measured by or determined by the income of the Trustee and reasonable attorneys’ fees and expenses)
incurred by it arising out of or in connection with the acceptance or administration of its duties under this Indenture, including the costs and expenses of enforcing this Indenture against the Company (including this Section 8.07) including
reasonable attorney’s fees and expenses and court costs and defending itself against any claim (whether asserted by the Company or any Holder or any other Person) or liability in connection with the exercise or performance of any of its powers
or duties hereunder. 

  
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 The Company need not reimburse the Trustee for any expense or indemnify it against any loss
or liability incurred by it resulting from its negligence or willful misconduct as finally adjudicated by a court of competent jurisdiction. 

To secure the Company’s payment obligations in this Section 8.07, the Trustee shall have a lien prior to the Securities on all money
or property held or collected by the Trustee, except such money or property held in trust to pay the principal of, interest on and amounts due upon conversion of, the Securities. 

When the Trustee incurs expenses or renders services after an Event of Default specified in clause (8) or clause (9) of
Section 7.01 occurs, the expenses and the compensation for the services (including the fees and expenses of its agents and counsel) are intended to constitute expenses of administration under any Bankruptcy Law. The obligations of the Company
under this Section 8.07 shall survive the termination or satisfaction and discharge of this Indenture or the resignation or removal of the Trustee for any reason. “Trustee” for the purposes of this Section 8.07 shall include any
predecessor Trustee and the Trustee in each of its capacities hereunder and each agent, custodian and other person employed to act hereunder; provided, however, that the negligence or willful misconduct of any Trustee hereunder shall
not affect the rights of any other Trustee hereunder. 
 Section 8.08. Replacement of Trustee. The Trustee may resign upon 30
days’ notice by so notifying the Company in writing and by mailing notice thereof to the Holders at their addresses as they appear on the Primary Registry. The Holders of a majority in aggregate principal amount of the Securities then
outstanding may remove the Trustee by so notifying the Trustee and the Company in writing upon 30 days’ notice and may, with the Company’s written consent, appoint a successor Trustee. The Company may remove the Trustee if: 

(1) the Trustee fails to comply with Section 8.10; 

(2) the Trustee is adjudged a bankrupt or an insolvent or relief is entered with respect to the Trustee under any Bankruptcy Law; 

(3) a receiver or other public officer takes charge of the Trustee or its property; or 

(4) the Trustee becomes incapable of acting. 

If the Trustee resigns or is removed or if a vacancy exists in the office of Trustee for any reason, the Company shall promptly appoint a
successor Trustee. The resignation or removal of a Trustee shall not be effective until a successor Trustee shall have delivered the written acceptance of its appointment as described below. 

If a successor Trustee does not take office within 60 days after the retiring Trustee resigns or is removed, the retiring Trustee, the Company
or the Holders of 10% in principal amount of the Securities then outstanding may petition any court of competent jurisdiction for the appointment of a successor Trustee at the expense of the Company. 

  
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 If the Trustee fails to comply with Section 8.10, any Holder who has been a Holder for
at least six months may petition any court of competent jurisdiction for the removal of the Trustee and the appointment of a successor Trustee. 

A successor Trustee shall deliver a written acceptance of its appointment to the retiring Trustee and to the Company. Immediately after that,
the retiring Trustee shall transfer all property held by it as Trustee to the successor Trustee (provided that all sums owing to the Trustee hereunder have been paid) and be released from its obligations (exclusive of any liabilities that the
retiring Trustee may have incurred while acting as Trustee) hereunder, the resignation or removal of the retiring Trustee shall become effective, and the successor Trustee shall have all the rights, powers and duties of the Trustee under this
Indenture. A successor Trustee shall mail notice of its succession to each Holder. 
 A retiring Trustee shall not be liable for the acts or
omissions of any successor Trustee after its succession. 
 Notwithstanding replacement of the Trustee pursuant to this Section 8.08,
the Company’s obligations under Section 8.07 shall continue for the benefit of the retiring Trustee. 
 Section 8.09.
Successor Trustee by Merger, Etc. If the Trustee consolidates with, merges or converts into, or transfers all or substantially all of its corporate trust assets (including the administration of this Indenture) to, another corporation, by sale
or otherwise, the resulting, surviving or transferee corporation, without any further act, shall be the successor Trustee, provided such transferee corporation shall qualify and be eligible under Section 8.10 without the execution or
filing of any paper or any further act on the part of any of the parties hereto. 
 Section 8.10. Eligibility; Disqualification.
The Trustee (or its parent holding company) shall have a combined capital and surplus of at least $50,000,000. If at any time the Trustee shall cease to satisfy such requirement, it shall resign immediately in the manner and with the effect
specified in this Article 8. 
 ARTICLE 9 

SATISFACTION AND DISCHARGE OF INDENTURE 

Section 9.01. Satisfaction and Discharge of Indenture. This Indenture shall upon request of the Company contained in an
Officers’ Certificate cease to be of further effect, and the Trustee, at the expense of the Company, shall execute proper instruments acknowledging satisfaction and discharge of this Indenture, when (a) (i) all Securities theretofore
authenticated and delivered (other than Securities that have been destroyed, lost or stolen and which have been replaced or paid as provided in Section 2.07) have been delivered to the Trustee for cancellation; or (ii) the Company has
deposited with the Trustee or delivered to Holders, as applicable, after the Securities have become due and payable, whether at the Maturity Date, any Redemption Date, any Fundamental Change Repurchase Date, upon conversion or otherwise, cash or
cash and/or, solely to satisfy the Company’s Conversion Obligation, shares of Common Stock, as applicable, sufficient to pay all of the outstanding Securities and all other sums due and payable under this Indenture by the Company; and
(b) the Company has delivered to the Trustee an Officers’ Certificate and an Opinion of Counsel, each stating that all conditions precedent herein provided for relating to the satisfaction and discharge of this Indenture have been complied
with. 

  
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 Notwithstanding the satisfaction and discharge of this Indenture, the obligations of the
Company to the Trustee under Section 8.07 shall survive and, if money shall have been deposited with the Trustee pursuant to paragraph (a)(ii) of this Section 9.01, the provisions of Section 9.02 and Section 9.04 shall survive
until the Securities have been paid in full. 
 Section 9.02. Application of Trust Money. Subject to the provisions of
Section 9.03, the Trustee or a Paying Agent shall segregate and hold in trust, for the benefit of the Holders, all money deposited with it pursuant to Section 9.01 and shall apply the deposited money and in accordance with this Indenture
and the Securities to the payment or delivery, as the case may be, of the principal of, and interest on, and the consideration due upon conversion of, the Securities. 

Section 9.03. Repayment to Company. The Trustee and each Paying Agent shall promptly pay to the Company upon request any excess
money (a) deposited with them pursuant to Section 9.01 and (b) held by them at any time. 
 The Trustee and each Paying Agent
shall, subject to compliance with applicable abandoned property law, pay to the Company upon request any money held by them for the payment or delivery, as the case may be, of principal, interest or amounts due upon conversion that remains unclaimed
for two years after a right to such money has matured. After payment or delivery to the Company, Holders entitled to money or share of Common Stock must look only to the Company for payment as general creditors unless an applicable abandoned
property law designates another Person and the Trustee and each Agent shall have no liability therefor. In the absence of a written request from the Company to return unclaimed funds or shares to the Company, the Trustee shall from time to time
deliver all unclaimed funds or shares to or as directed by applicable escheat authorities, as determined by the Trustee in its sole discretion, in accordance with the customary practices and procedures of the Trustee. Any unclaimed funds or shares
held by the Trustee pursuant to this Section 9.03 shall be held uninvested and without any liability for interest. 

Section 9.04. Reinstatement. If the Trustee or any Paying Agent is unable to apply any money or shares of Common Stock in
accordance with Section 9.02 by reason of any legal proceeding or by reason of any order or judgment of any court or governmental authority enjoining, restraining or otherwise prohibiting such application, then the Company’s obligations
under this Indenture and the Securities shall be revived and reinstated as though no deposit had occurred pursuant to Section 9.01 until such time as the Trustee or such Paying Agent is permitted to apply all such money or shares of Common
Stock in accordance with Section 9.02; provided, however, that if the Company has made any payment or delivery, as the case may be, of the principal of, interest on, or amounts due upon conversion of, any Securities because of the
reinstatement of its obligations, the Company shall be subrogated to the rights of the Holders of such Securities to receive any such payment or delivery from the money or shares of Common Stock held by the Trustee or such Paying Agent. 

  
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 ARTICLE 10 

AMENDMENTS, SUPPLEMENTS AND WAIVERS 

Section 10.01. Without Consent of Holders. The Company and the Trustee may amend or supplement this Indenture or the Securities
without notice to, or the consent of, any Holder: 
 (a) to cure any ambiguity, defect or inconsistency that does not materially adversely
affect Holders, as determined in good faith by the Company; 
 (b) to provide for the assumption by a Successor Company of the Company’s
obligations under this Indenture pursuant to Article 6; 
 (c) to add guarantees with respect to the Securities; 

(d) to secure the Company’s obligations with respect to the Securities; 

(e) to increase the Conversion Rate; 

(f) to irrevocably select a Settlement Method and/or Specified Dollar Amount, or eliminate the Company’s right to choose a particular
Settlement Method, on conversion of the Securities; 
 (g) to add to the covenants of the Company for the benefit of the Holders or to
surrender any right or power conferred upon the Company; 
 (h) to make any other change that does not adversely affect the rights of any
Holder, as determined by the Company in good faith; 
 (i) in connection with any Merger Event, to provide that the Securities are
convertible into Reference Property, subject to the provisions of Section 4.02, and make such related changes to the terms of the Securities to the extent expressly required by Section 4.07; 

(j) to conform the provisions of this Indenture to the “Description of notes” section in the preliminary offering memorandum relating
to the offering and sale of the Securities, as supplemented by the related pricing term sheet as evidenced by an Officers’ Certificate; or 

(k) to evidence and provide for the acceptance of appointment hereunder by a successor Trustee with respect to the Securities and to add to or
change any of the provisions of this Indenture as shall be necessary for or facilitate the administration of the trusts hereunder by such successor Trustee, pursuant to the provisions of Section 8.08. 

Upon the request of the Company accompanied by a resolution of its Board of Directors authorizing the execution of any such amended or
supplemental indenture, and upon receipt by the Trustee of the documents described in Section 10.06 and Section 11.04, the Trustee shall join with the Company in the execution of any amended or supplemental indenture authorized or
permitted by the terms of this Indenture and to make any further appropriate agreements and stipulations that may be therein contained, but the Trustee shall not be obligated to enter into such amended or supplemental indenture that affects its own
rights, duties or immunities under this Indenture or otherwise. 

  
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 Section 10.02. With Consent of Holders. The Company and the Trustee may amend or
supplement this Indenture or the Securities with the written consent of the Holders of at least a majority in aggregate principal amount of the Securities then outstanding. Subject to the exclusions set forth in Section 7.05, the Holders of at
least a majority in aggregate principal amount of the Securities then outstanding may waive compliance in a particular instance by the Company with any provision of this Indenture or the Securities without notice to any Holder. However,
notwithstanding the foregoing but subject to Section 10.04, without the written consent of the Holder of each outstanding Security, an amendment, supplement or waiver, including a waiver pursuant to Section 7.05, may not: 

(a) change the stated maturity of the principal of, or interest on, any Security; 

(b) reduce the principal amount of or interest on any Security; 

(c) reduce the amount of principal payable upon acceleration of the maturity of any Security; 

(d) change the place or currency of payment of principal of, or interest on, any Security; 

(e) impair the right to institute suit for the enforcement of any payment on, or with respect to, any Security; 

(f) modify the provisions with respect to the Company’s obligation to redeem the Securities or to repurchase Securities pursuant to
Article 3 upon a Fundamental Change in a manner adverse to Holders; 
 (g) change the ranking of the Securities; 

(h) adversely affect the right of Holders to convert Securities other than as required in or under Article 4 of this Indenture: 

(i) reduce the percentage in principal amount of outstanding Securities required for modification or amendment of this Indenture; 

(j) reduce the percentage in principal amount of outstanding Securities necessary for waiver of compliance with any provision of this Indenture
or the waiver of any Event of Default under this Indenture; or 
 (k) modify provisions of this Section 10.02 or Section 7.05 in a
manner adverse to the Holders. 
 It shall not be necessary for the consent of the Holders under this Section 10.02 to approve the
particular form of any proposed amendment, supplement or waiver, but it shall be sufficient if such consent approves the substance thereof. 

  
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 Upon the request of the Company accompanied by a resolution of its Board of Directors
authorizing the execution of any such amended or supplemental indenture, and upon the filing with the Trustee of evidence satisfactory to the Trustee of the consent of the Holders as aforesaid, and upon receipt by the Trustee of the documents
described in Section 10.06 and Section 11.04, the Trustee shall join with the Company in the execution of such amended or supplemental indenture unless such amended or supplemental indenture directly affects the Trustee’s own rights,
duties or immunities under this Indenture or otherwise, in which case the Trustee may in its discretion, but shall not be obligated to, enter into such amended or supplemental indenture. 

After an amendment, supplement or waiver under this Section 10.02 or Section 10.01 becomes effective, the Company shall mail to the
Holders affected thereby (with a copy to the Trustee) a notice briefly describing the amendment, supplement or waiver. Any failure of the Company to mail such notice, or any defect therein, shall not, however, in any way impair or affect the
validity of any such amendment, supplement or waiver. 
 Section 10.03. [Reserved]. 

Section 10.04. Revocation and Effect of Consents. Until an amendment, supplement or waiver becomes effective, a consent to it by a
Holder is a continuing consent by the Holder and every subsequent Holder of a Security or portion of a Security that evidences the same debt as the consenting Holder’s Security, even if notation of the consent is not made on any Security.
However, any such Holder or subsequent Holder may revoke the consent as to its Security or portion of a Security if the Trustee receives the notice of revocation before the date the amendment, supplement or waiver becomes effective. 

After an amendment, supplement or waiver becomes effective, it shall bind every Holder, unless it makes a change described in any of clauses
(a) through (k) of Section 10.02. In that case, the amendment, supplement or waiver shall bind each Holder of a Security who has consented to it and every subsequent Holder of a Security or portion of a Security that evidences the same
debt as the consenting Holder’s Security. 
 Section 10.05. Notation on or Exchange of Securities. The Trustee may place an
appropriate notation about an amendment, supplement or waiver on any Security thereafter authenticated. The Company in exchange for all Securities may issue and the Trustee shall, upon receipt of a Company Order, authenticate new Securities that
reflect the amendment, supplement or waiver. Failure to make the appropriate notation or issue a new Security shall not affect the validity and effect of such amendment, supplement or waiver. 

Section 10.06. Trustee to Sign Amendments, Etc. The Trustee shall sign any amendment or supplemental indenture authorized pursuant
to this Article 10 if the amendment or supplemental indenture does not adversely affect the rights, duties, liabilities or immunities of the Trustee. If it does, the Trustee may, in its sole discretion, but need not sign it. In signing or refusing
to sign such amendment or supplemental indenture, the Trustee shall be provided with and, subject to Section 8.01, shall be fully protected in relying upon in addition to the documents required by Section 11.04, an Officers’
Certificate and an Opinion of Counsel each stating that such amendment or supplemental indenture is authorized or permitted by this Indenture, and an 

  
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Opinion of Counsel stating that it will be valid and binding upon the Company and enforceable in accordance with its terms (subject to customary exceptions as to bankruptcy, insolvency,
creditors’ rights and equitable principles). The Company may not sign an amendment or supplemental indenture until the Board of Directors approves it. 

Section 10.07. Effect of Supplemental Indentures. Upon the execution of any supplemental indenture under this Article 10, this
Indenture shall be modified in accordance therewith, and such supplemental indenture shall form a part of this Indenture for all purposes, and every Holder of Securities theretofore or thereafter authenticated and delivered hereunder shall be bound
thereby. 
 ARTICLE 11 

MISCELLANEOUS 

Section 11.01. [Reserved]. 

Section 11.02. Notices. Any notice or communication to the Company or the Trustee under this Indenture shall be given in writing
and delivered in Person, by first-class mail (registered or certified, return receipt requested), facsimile transmission (confirmed by delivery in Person or by first-class mail (registered or certified, return receipt requested)), by guaranteed
overnight courier or by electronic mail to the applicable e-mail address, as follows: 
 If to the
Company, to: 
 Amyris, Inc. 

5885 Hollis Street, Suite 100 

Emeryville, California 94608 

Attention: Chief Financial Officer 

Email: kieftenbeld@amyris.com 

chieflegalofficer@amyris.com 

With a copy to: 

Fenwick & West LLP 

801 California Street 
 Mountain
View, California 94041 
 Attention: David Michaels, Esq. 

Fax: (650) 938-5200 

If to the Trustee, to: 
 U.S.
Bank National Association 
 633 West Fifth Street, 24th Floor 

Los Angeles, CA 90071 
 Attn: B.
Scarbrough (Amyris Convertible Senior Notes due 2026) 
 Fax: (213) 615-6197 

  
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 All notices and communications (other than those sent to Holders) shall be deemed to have
been duly given at the time delivered by hand, if personally delivered; five Business Days after being deposited in the mail, if mailed by first-class mail (registered or certified, return receipt requested) or overnight courier service; upon
acknowledgment of receipt, if transmitted by facsimile; the next Business Day after timely delivery to the courier, if sent by guaranteed overnight courier; and when sent by attachment in PDF format, if sent by
e-mail, absent receipt of a failure to deliver notice (it being understood that an “out of office” reply does not constitute a failure to deliver notice for this purpose) (provided that if
such notice or other communication is not sent during normal business hours of the recipient, such notice or communication shall be deemed to have been sent at the opening of business on the next Business Day). All notices to the Trustee and the
Conversion Agent shall be sufficiently given upon actual receipt by the Trustee or the Conversion Agent. 
 The Company or the Trustee by
notice to the other may designate additional or different addresses for subsequent notices or communications. 
 Any notice or communication
mailed to a Holder shall be mailed by first-class mail or delivered by guaranteed overnight courier or by other electronic means to it at its address shown on the register kept by the Primary Registrar. Any notice or communication shall also be so
mailed to any Person described in TIA Section 313(c), to the extent required by the TIA. 
 Failure to mail a notice or communication
to a Holder or any defect in it shall not affect its sufficiency with respect to other Holders. If a notice or communication to a Holder is mailed in the manner provided above, it is duly given, whether or not the addressee receives it. 

If the Company mails a notice or communication to Holders, it shall mail a copy to the Trustee and each Agent at the same time. 

Notwithstanding any other provision of this Indenture or any Security, where this Indenture or any Security provides for notice of any event
or any other communication to a Holder of a Global Security (whether by mail or otherwise), such notice shall be sufficiently given if given to the Depositary (or its designee) pursuant to the standing instructions from the Depositary (or its
designee), including by electronic mail in accordance with accepted practices at the Depositary, and in compliance with the Applicable Procedures. 

The Trustee shall have the right to accept and act upon instructions, including funds transfer instructions (“Instructions”)
given by the Company pursuant to this Indenture and delivered using unsecured email, facsimile transmission or other similar unsecured electronic methods (including PDF files) (“Electronic Means”); provided, however,
that the Company shall provide to the Trustee an incumbency certificate listing Officers with the authority to provide such Instructions (each, an “Authorized Officer”) and containing specimen signatures of such Authorized Officers,
which incumbency certificate shall be amended by the Company whenever a person is to be added or deleted from the listing. If the Company elects to give the Trustee Instructions using Electronic Means and the Trustee in its discretion elects to act
upon such Instructions, the Trustee’s understanding of such Instructions shall be deemed controlling. The Company understands and agrees that the Trustee cannot determine the identity of the actual


  
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sender of such Instructions and that the Trustee shall conclusively presume that Instructions that purport to have been sent by an Authorized Officer listed on the incumbency certificate provided
to the Trustee have been sent by such Authorized Officer. The Company shall be responsible for ensuring that only Authorized Officers transmit such Instructions to the Trustee and that the Company and all Authorized Officers are solely responsible
to safeguard the use and confidentiality of applicable user and authorization codes, passwords and/or authentication keys upon receipt by the Company. The Trustee shall not be liable for any losses, costs or expenses arising directly or indirectly
from the Trustee’s reliance upon and compliance with such Instructions notwithstanding such Instructions conflict or are inconsistent with a subsequent written instruction. The Company agrees: (a) to assume all risks arising out of the use
of Electronic Means to submit Instructions to the Trustee, including without limitation the risk of the Trustee acting on unauthorized Instructions, and the risk of interception and misuse by third parties; and (b) to notify the Trustee
immediately upon learning of any compromise or unauthorized use of the security procedures. 
 Section 11.03. Communications by
Holders with Other Holders. Holders may communicate pursuant to TIA Section 312(b) with other Holders with respect to their rights under this Indenture or the Securities. The Company, the Trustee, the Registrar and any other Person shall
have the protection of TIA Section 312(c). 
 Section 11.04. Certificate and Opinion as to Conditions Precedent. 

(a) Upon any request or application by the Company to the Trustee to take any action under this Indenture, the Company shall furnish to the
Trustee: 
 (i) an Officers’ Certificate stating that all conditions precedent (including any covenants, compliance with
which constitutes a condition precedent), if any, provided for in this Indenture relating to the proposed action have been complied with; and 

(ii) an Opinion of Counsel stating that, in the opinion of such counsel, all such conditions precedent (including any
covenants, compliance with which constitutes a condition precedent) have been complied with. 
 (b) Each Officers’ Certificate and
Opinion of Counsel with respect to compliance with a condition or covenant provided for in this Indenture shall include: 

(i) a statement that the Person making such certificate or opinion has read such covenant or condition; 

(ii) a brief statement as to the nature and scope of the examination or investigation upon which the statements or opinions
contained in such certificate or opinion are based; 
 (iii) a statement that, in the opinion of such Person, he or she has
made such examination or investigation as is necessary to enable him or her to express an informed opinion as to whether or not such covenant or condition has been complied with; and 

  
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 (iv) a statement as to whether or not, in the opinion of such Person, such
condition or covenant has been complied with; 
 provided, however, that with respect to matters of fact an Opinion of Counsel may rely on an
Officers’ Certificate or certificates of public officials. 
 Section 11.05. Record Date for Vote or Consent of Holders.
The Company (or, in the event deposits have been made pursuant to Section 9.01, the Trustee) may set a record date for purposes of determining the identity of Holders entitled to vote or consent to any action by vote or consent authorized or
permitted under this Indenture, which record date shall not be more than 30 days prior to the date of the commencement of solicitation of such action. Notwithstanding the provisions of Section 10.04, if a record date is fixed, those Persons who
were Holders of Securities at the close of business on such record date (or their duly designated proxies), and only those Persons, shall be entitled to take such action by vote or consent or to revoke any vote or consent previously given, whether
or not such Persons continue to be Holders after such record date. 
 Section 11.06. Rules by Trustee, Paying Agent, Registrar and
Conversion Agent. The Trustee may make reasonable rules (not inconsistent with the terms of this Indenture) for action by or at a meeting of Holders. Any Registrar, Paying Agent or Conversion Agent may make reasonable rules for its functions.

 Section 11.07. Legal Holidays. If a payment date is a Legal Holiday, payment shall be made on the next succeeding day that is
not a Legal Holiday, and no interest shall accrue for the intervening period. If a Regular Record Date is a Legal Holiday, the Regular Record Date shall not be affected. 

Section 11.08. Governing Law; Jurisdiction. THIS INDENTURE AND THE SECURITIES, AND ANY CLAIM, CONTROVERSY OR DISPUTE ARISING UNDER
OR RELATED TO THIS INDENTURE OR THE SECURITIES, SHALL BE GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH, THE LAWS OF THE STATE OF NEW YORK. 

The Company irrevocably consents and agrees, for the benefit of the Holders from time to time of the Securities and the Trustee, that any
legal action, suit or proceeding against it with respect to obligations, liabilities or any other matter arising out of or in connection with this Indenture or the Securities may be brought in the courts of the State of New York or the courts of the
United States located in the Borough of Manhattan, The City of New York, New York and, until amounts due and to become due in respect of the Securities have been paid, hereby irrevocably consents and submits to the nonexclusive jurisdiction of each
such court in personam, generally and unconditionally with respect to any action, suit or proceeding for itself in respect of its properties, assets and revenues. 

The Company irrevocably and unconditionally waives, to the fullest extent permitted by law, any objection which it may now or hereafter have
to the laying of venue of any of the aforesaid actions, suits or proceedings arising out of or in connection with this Indenture brought in the courts of the State of New York or the courts of the United States located in the Borough of Manhattan,
The City of New York, New York and hereby further irrevocably and unconditionally waives and agrees not to plead or claim in any such court that any such action, suit or proceeding brought in any such court has been brought in an inconvenient forum.


  
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 Section 11.09. No Adverse Interpretation of Other Agreements. This Indenture may
not be used to interpret another indenture, loan or debt agreement of the Company or a Subsidiary of the Company. Any such indenture, loan or debt agreement may not be used to interpret this Indenture. 

Section 11.10. Interpretation. Unless specifically referenced therein, no provision of this Indenture shall be understood with
respect to, interpreted by reference to, or incorporate any meaning relating to, any provisions, requirements or limitations set forth in the TIA or any related rules, regulations, case law or other applicable guidance. 

Section 11.11. No Personal Liability of Directors, Officers, Employees or Shareholders. No past, present or future director,
officer, employee, incorporator or shareholder of the Company, as such, shall have any liability for any obligations of the Company under the Securities, this Indenture or for any claim based on, in respect of, or by reason of, such obligations or
their creation. Each Holder by accepting a Security waives and releases all such liability. The waiver and release are part of the consideration for issuance of the Securities. 

Section 11.12. Successors. All agreements of the Company in this Indenture and the Securities shall bind its successor. All
agreements of the Trustee in this Indenture shall bind its successor. 
 Section 11.13. Multiple Counterparts. The parties may
sign multiple counterparts of this Indenture. The exchange of copies of this Indenture and of signature pages by facsimile, PDF transmission or electronic mail (including in “.pdf” format or any electronic signature covered by the U.S.
federal ESIGN Act of 2000, Uniform Electronic Transactions Act, the Electronic Signatures and Records Act or other applicable law, e.g., www.docusign.com) shall constitute effective execution and delivery of this Indenture as to the parties hereto
and may be used in lieu of the original Indenture for all purposes. Signatures of the parties hereto transmitted by facsimile, PDF or electronic mail shall be deemed to be their original signatures for all purposes. This Indenture shall be valid,
binding, and enforceable against a party when executed and delivered by an authorized individual on behalf of the party by means of (i) an original manual signature, (ii) a faxed, scanned, or photocopied manual signature or (iii) any
other electronic signature permitted by the federal Electronic Signatures in Global and National Commerce Act, state enactments of the Uniform Electronic Transactions Act and/or any other relevant electronic signatures law, including any relevant
provisions of the Uniform Commercial Code (collectively, “Signature Law”), in each case to the extent applicable. Each faxed, scanned, or photocopied manual signature, or other electronic signature, shall for all purposes have the
same validity, legal effect, and admissibility in evidence as an original manual signature. Each party hereto shall be entitled to conclusively rely upon, and shall have no liability with respect to, any faxed, scanned, or photocopied manual
signature, or other electronic signature, of any other party and shall have no duty to investigate, confirm or otherwise verify the validity or authenticity thereof. This Indenture may be executed in any number of counterparts, each of which shall
be deemed to be an original, but such counterparts shall, together, constitute one and the same instrument. For 

  
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the avoidance of doubt, original manual signatures shall be used for execution or endorsement of writings when required under any Signature Law due to the character or intended character of the
writings. All notices, approvals, consents, requests and any communications hereunder must be in writing (provided that any such communication sent to the Trustee hereunder must be in the form of a document that is signed manually or by way of a
digital signature provided by Docusign (or such other digital signature provider as specified in writing to the Trustee by the authorized representative), in English. The Company agrees to assume all risks arising out of the use of using digital
signatures and electronic methods to submit communications to the Trustee, including without limitation the risk of the Trustee acting on unauthorized instructions, and the risk of interception and misuse by third parties. 

Section 11.14. Separability. In case any provisions in this Indenture or in the Securities shall be invalid, illegal or
unenforceable, the validity, legality and enforceability of the remaining provisions shall not in any way be affected or impaired thereby. 

Section 11.15. [Reserved.]  

Section 11.16. Table of Contents, Headings, Etc. The table of contents and headings of the Articles and Sections of this Indenture
have been inserted for convenience of reference only, are not to be considered a part hereof, and shall in no way modify or restrict any of the terms or provisions hereof. 

Section 11.17. Force Majeure. In no event shall the Trustee or any Agent be responsible or liable for any failure or delay in the
performance of its obligations hereunder arising out of or caused by, directly or indirectly, forces beyond its control, including, without limitation, strikes, work stoppages, accidents, acts of war or terrorism, civil or military disturbances,
nuclear or natural catastrophes or acts of God, and interruptions, loss or malfunctions of utilities, communications or computer (software and hardware) services, or other unavailability of the Federal Reserve Bank wire or facsimile or other wire or
communication facility; provided that the Trustee or any such Agent shall use reasonable efforts consistent with accepted practices in the banking industry to resume performance as soon as practicable under the circumstances. 

Section 11.18. Waiver of Jury Trial. EACH OF THE COMPANY AND THE TRUSTEE HEREBY IRREVOCABLY WAIVES, TO THE FULLEST EXTENT
PERMITTED BY APPLICABLE LAW, ANY AND ALL RIGHT TO TRIAL BY JURY IN ANY LEGAL PROCEEDING ARISING OUT OF OR RELATING TO THIS INDENTURE, THE SECURITIES OR THE TRANSACTIONS CONTEMPLATED HEREBY. 

Section 11.19. Calculations. The Company shall be responsible for making all calculations called for under the Securities or this
Indenture. These calculations include, but are not limited to, determinations of the Last Reported Sale Prices of the Common Stock, the Daily VWAPs, the Daily Conversion Values, the Daily Settlement Amounts, accrued interest payable on the
Securities and the Conversion Rate of the Securities and any adjustments thereto. The Company shall make all these calculations in good faith and, absent manifest error, the Company’s calculations shall be final and binding on Holders of
Securities, the Trustee and the Conversion Agent. The Company shall provide a schedule of its calculations to each of the Trustee and the Conversion Agent, and each of the Trustee and Conversion Agent is entitled to rely conclusively upon the
accuracy of the Company’s calculations without independent verification. The Trustee will forward the Company’s calculations to any Holder of Securities upon the request of that Holder at the sole cost and expense of the Company. 

  
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 Section 11.20. U.S.A. PATRIOT Act. The
Company acknowledges that in accordance with Section 326 of the U.S.A. PATRIOT Act, the Trustee, like all financial institutions and in order to help fight the funding of terrorism and money laundering, is required to obtain, verify and record
information that identifies each person or legal entity that establishes a relationship or opens an account with the Trustee. The parties to this Indenture agree that they will provide the Trustee with such information as it may request in order for
the Trustee to satisfy the requirements of the U.S.A. PATRIOT Act. 
 [SIGNATURE PAGE FOLLOWS] 

 

  
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 IN WITNESS WHEREOF, the parties hereto have hereunto set their hands as of the date and year
first above written. 
  

			
	AMYRIS, INC.
		
	By:	 	 /s/ John Melo

		 	Name: John Melo
		 	Title: Chief Executive Officer
		
	By:	 	 /s/ Han Kieftenbeld

		 	Name: Han Kieftenbeld
		 	Title: Chief Financial Officer



  
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	U.S. BANK NATIONAL ASSOCIATION, AS TRUSTEE.
		
	By:	 	 /s/ Fonda Hall

		 	Name: Fonda Hall
		 	Title: Vice President


  

  
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 EXHIBIT A 

[Form of Face of Security] 

NO AFFILIATE (AS DEFINED IN RULE 144 UNDER THE SECURITIES ACT) OF AMYRIS, INC. OR PERSON THAT HAS BEEN AN AFFILIATE (AS DEFINED IN RULE 144
UNDER THE SECURITIES ACT) OF AMYRIS, INC. DURING THE IMMEDIATELY PRECEDING THREE MONTHS MAY PURCHASE, OTHERWISE ACQUIRE OR HOLD THIS SECURITY OR A BENEFICIAL INTEREST HEREIN. 

[INCLUDE FOLLOWING LEGEND IF A GLOBAL SECURITY] 

[UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY TO THE COMPANY OR ITS AGENT FOR
REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY (AND ANY PAYMENT HEREON
IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL SINCE THE
REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN. THIS SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE THEREOF. THIS SECURITY IS
EXCHANGEABLE FOR SECURITIES REGISTERED IN THE NAME OF A PERSON OTHER THAN THE DEPOSITARY OR ITS NOMINEE ONLY IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE AND, UNLESS AND UNTIL IT IS EXCHANGED IN WHOLE OR IN PART FOR SECURITIES IN
DEFINITIVE FORM, THIS SECURITY MAY NOT BE TRANSFERRED EXCEPT AS A WHOLE BY THE DEPOSITARY TO A NOMINEE OF THE DEPOSITARY OR BY A NOMINEE OF THE DEPOSITARY TO THE DEPOSITARY OR ANOTHER NOMINEE OF THE DEPOSITARY OR BY THE DEPOSITARY OR ANY SUCH
NOMINEE TO A SUCCESSOR DEPOSITARY OR A NOMINEE OF SUCH SUCCESSOR DEPOSITARY.] 
 [INCLUDE FOLLOWING LEGEND IF A RESTRICTED SECURITY] 

[THIS SECURITY AND THE COMMON STOCK, IF ANY, ISSUABLE UPON CONVERSION OF THIS SECURITY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF
1933, AS AMENDED (THE “SECURITIES ACT”), AND MAY NOT BE OFFERED, SOLD, PLEDGED OR OTHERWISE TRANSFERRED EXCEPT IN ACCORDANCE WITH THE FOLLOWING SENTENCE. BY ITS ACQUISITION HEREOF OR OF A BENEFICIAL INTEREST HEREIN, THE ACQUIRER:


  
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 (i) REPRESENTS THAT IT AND ANY ACCOUNT FOR WHICH IT IS ACTING IS A
“QUALIFIED INSTITUTIONAL BUYER” (WITHIN THE MEANING OF RULE 144A UNDER THE SECURITIES ACT) AND THAT IT EXERCISES SOLE INVESTMENT DISCRETION WITH RESPECT TO EACH SUCH ACCOUNT, AND 

(ii) AGREES FOR THE BENEFIT OF AMYRIS, INC. (THE “COMPANY”) THAT IT WILL NOT OFFER, SELL, PLEDGE OR OTHERWISE
TRANSFER THIS SECURITY OR ANY BENEFICIAL INTEREST HEREIN PRIOR TO THE DATE THAT IS THE LATER OF (X) ONE YEAR AFTER THE LAST ORIGINAL ISSUE DATE HEREOF OR SUCH SHORTER PERIOD OF TIME AS PERMITTED BY RULE 144 UNDER THE SECURITIES ACT OR ANY
SUCCESSOR PROVISION THERETO AND (Y) SUCH LATER DATE, IF ANY, AS MAY BE REQUIRED BY APPLICABLE LAW, EXCEPT: 
 (A) TO THE
COMPANY OR ANY SUBSIDIARY OF THE COMPANY, OR 
 (B) PURSUANT TO A REGISTRATION STATEMENT THAT HAS BECOME EFFECTIVE UNDER THE
SECURITIES ACT, OR 
 (C) TO A PERSON THAT IS REASONABLY BELIEVED TO BE A QUALIFIED INSTITUTIONAL BUYER THAT IS PURCHASING
FOR ITS OWN ACCOUNT OR FOR THE ACCOUNT OF ANOTHER QUALIFIED INSTITUTIONAL BUYER AND TO WHOM NOTICE IS GIVEN THAT THE TRANSFER IS BEING MADE IN RELIANCE ON RULE 144A, ALL IN COMPLIANCE WITH RULE 144A (IF AVAILABLE), OR 

(D) PURSUANT TO AN EXEMPTION FROM REGISTRATION PROVIDED BY RULE 144 UNDER THE SECURITIES ACT (IF AVAILABLE), OR ANY OTHER
AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT. 
 PRIOR TO THE REGISTRATION OF ANY TRANSFER IN ACCORDANCE
WITH CLAUSE (2)(D) ABOVE, THE COMPANY AND THE TRUSTEE RESERVE THE RIGHT TO REQUIRE THE DELIVERY OF SUCH LEGAL OPINIONS, CERTIFICATIONS OR OTHER EVIDENCE AS MAY REASONABLY BE REQUIRED IN ORDER FOR THE COMPANY TO DETERMINE THAT THE PROPOSED TRANSFER
IS BEING MADE IN COMPLIANCE WITH THE SECURITIES ACT AND APPLICABLE STATE SECURITIES LAWS. NO REPRESENTATION IS MADE AS TO THE AVAILABILITY OF ANY EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT.] 

  
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 AMYRIS, INC. 

1.50% CONVERTIBLE SENIOR NOTES DUE 2026 
  

			
	 No. [ ]
	  	[Initially]1 $[________]
		
	 CUSIP No.: 03236M AH42
	  	
		
	 ISIN No.: US03236MAH43
	  	

 Amyris, Inc., a Delaware corporation (the “Company,” which term shall include any successor
corporation under the Indenture referred to on the reverse hereof), promises to pay to [CEDE & CO., in accordance with the rules and procedures of the Depositary]3 [_______]4, or registered assigns, the principal sum [as set forth in the “Schedule of Exchanges of Securities” attached hereto]5 [of
$[_______]]6, which amount, taken together with the principal amounts of all other outstanding Securities, shall not, unless permitted by the Indenture, exceed $690,000,000 in aggregate at any
time, on November 15, 2026, and interest thereon as set forth below. 
 This Security shall bear interest at the rate of 1.50% per year
from November 15, 2021, or from the most recent date to which interest had been paid or provided for to, but excluding, the next scheduled Interest Payment Date until November 15, 2026. Interest is payable semiannually in arrears on each
May 15 and November 15, commencing on May 15, 2022, to Holders of record at the close of business on the preceding May 1 or November 1 (whether or not such day is a Business Day), respectively. Additional Interest will be
payable as set forth in Section 5.02(d), Section 5.02(e) and Section 7.04 of the within-mentioned Indenture, and any reference to interest on, or in respect of, any Security therein shall be deemed to include Additional Interest if,
in such context, Additional Interest is, was or would be payable pursuant to any of Section 5.02(d), Section 5.02(e) or Section 7.04 and any express mention of the payment of Additional Interest in any provision therein shall not be
construed as excluding Additional Interest in those provisions thereof where such express mention is not made. Interest will be computed on the basis of a 360-day year of twelve
30-day months. 
  

	1 	 Include if a global security. 



	2 	 This Security will be deemed to be identified by CUSIP No. 03236M AJ0 from and after such time when the
Company delivers, pursuant to Section 2.06(d) of the within-mentioned Indenture, written notice to the Trustee of the occurrence of the Resale Restriction Termination Date and the removal of the restrictive legend affixed to this Security in
accordance with the Applicable Procedures. 



	3 	 Include if a global security. 



	4 	 Include if a certificated security. 



	5 	 Include if a global security. 



	6 	 Include if a certificated security. 




  
 A-3 












 Any Defaulted Amounts shall accrue interest per annum at the rate borne by the Securities,
subject to the enforceability thereof under applicable law, from, and including, the relevant payment date to, but excluding, the date on which such Defaulted Amounts shall have been paid by the Company, at its election, in accordance with
Section 2.02(e) of the Indenture. 
 The Company shall pay the principal of and interest on this Security so long as such Security is a
Global Security, in immediately available funds to the Depositary or its nominee, as the case may be, as the registered Holder of such Security. As provided in and subject to the provisions of the Indenture, the Company shall pay the principal of
any Securities (other than Securities that are Global Securities) at the office or agency designated by the Company for that purpose. The Company has initially designated the Trustee as Paying Agent, Primary Registrar, Securities Custodian and
Conversion Agent and the Corporate Trust Office of the Trustee as an office or agency of the Company for each of the aforesaid purposes. 

Reference is made to the further provisions of this Security set forth on the reverse hereof, including, without limitation, provisions giving
the Holder of this Security the right to convert this Security into cash, shares of Common Stock or a combination of cash and shares of Common Stock, at the Company’s election, on the terms and subject to the limitations set forth in the
Indenture. Such further provisions shall for all purposes have the same effect as though fully set forth at this place. 
 This Security
shall not be valid or become obligatory for any purpose until the certificate of authentication hereon shall have been manually signed by the Trustee or a duly authorized authenticating agent under the Indenture. 

[SIGNATURE PAGE FOLLOWS] 

  
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 IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed. 

 

			
	AMYRIS, INC.
		
	By:	 	
                    


		 	Name:
		 	Title:



  
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 Dated: 

TRUSTEE’S CERTIFICATE OF AUTHENTICATION 

This is one of the Securities referred to in the within-mentioned Indenture. 

 

			
	U.S. BANK NATIONAL ASSOCIATION, AS TRUSTEE
		
	By:	 	
                

		 	Authorized Signatory


  
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 [FORM OF REVERSE OF SECURITY] 

AMRYIS, INC. 
 1.50%
CONVERTIBLE SENIOR NOTES DUE 2026 
 This Security is one of a duly authorized issuance of Securities of the Company, designated as its
1.50% Convertible Senior Notes due 2026 (the “Securities”), limited in aggregate principal amount of up to $690,000,000, all issued or to be issued under and pursuant to an Indenture dated as of November 15, 2021 (the
“Indenture”), between the Company and U.S. Bank National Association (the “Trustee”), to which Indenture and all indentures supplemental thereto reference is hereby made for a description of the rights, limitations
of rights, obligations, duties and immunities thereunder of the Trustee, the Company and the Holders of the Securities. Additional Securities may be issued in an unlimited aggregate principal amount, subject to certain conditions specified in the
Indenture. 
 In case an Event of Default, as defined in the Indenture, shall have occurred and be continuing, the principal of all
Securities may be declared, by either the Trustee or Holders of at least 25% in aggregate principal amount of Securities then outstanding, and upon said declaration shall become, due and payable, in the manner, with the effect and subject to the
conditions and certain exceptions set forth in the Indenture. In case an Event of Default occurs as a result of certain events of bankruptcy, insolvency or reorganization of the Company, the principal of all Securities then outstanding shall ipso
facto become and be immediately due and payable without any declaration or other act on the part of the Trustee or any Holder. 
 Subject to
the terms and conditions of the Indenture, the Company will make all payments and deliveries in respect of the Fundamental Change Repurchase Price, the Redemption Price of Securities called for Optional Redemption on any Redemption Date and the
principal amount on the Maturity Date, as the case may be, to the Holder who surrenders a Security to a Paying Agent to collect such payments in respect of the Security. The Company will pay cash amounts in money of the United States that at the
time of payment is legal tender for payment of public and private debts. 
 The Indenture contains provisions permitting the Company and the
Trustee in certain circumstances, without the consent of the Holders of the Securities, and in certain other circumstances, with the consent of the Holders of not less than a majority in aggregate principal amount of the Securities at the time
outstanding, evidenced as in the Indenture provided, to execute supplemental indentures modifying the terms of the Indenture and the Securities as described therein. It is also provided in the Indenture that, subject to certain exceptions, the
Holders of a majority in aggregate principal amount of the Securities at the time outstanding may on behalf of the Holders of all of the Securities waive any past Default or Event of Default under the Indenture and its consequences. 

  
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 The Securities are issuable in registered form without coupons in denominations of $1,000
principal amount and integral multiples thereof. At the office or agency of the Company referred to on the face hereof, and in the manner and subject to the limitations provided in the Indenture, Securities may be exchanged for a like aggregate
principal amount of Securities of other authorized denominations, without payment of any service charge but, if required by the Company or Trustee, with payment of a sum sufficient to cover any transfer or similar tax that may be imposed in
connection therewith as a result of the name of the Holder of the new Securities issued upon such exchange of Securities being different from the name of the Holder of the old Securities surrendered for such exchange. 

The Securities shall be redeemable at the Company’s option on or after November 20, 2024 in accordance with the terms and subject to
the conditions specified in the Indenture. No sinking fund is provided for the Securities. 
 Upon the occurrence of a Fundamental Change,
the Holder has the right, at such Holder’s option, to require the Company to repurchase for cash all of such Holder’s Securities or any portion thereof (in principal amounts of $1,000 or integral multiples thereof) on the Fundamental
Change Repurchase Date at a price equal to the Fundamental Change Repurchase Price. 
 Subject to the provisions of the Indenture, the
Holder hereof has the right, at its option, prior to the close of business on the Business Day immediately preceding June 15, 2026 only upon the occurrence of certain conditions specified in the Indenture, and on or after June 15, 2026
until the close of business on the second Scheduled Trading Day immediately preceding November 15, 2026 regardless of the occurrence of such conditions, to convert all of its Securities or any portion thereof that is $1,000 or an integral
multiple thereof, into cash, shares of Common Stock or a combination of cash and shares of Common Stock, at the Company’s election, at the Conversion Rate specified in the Indenture, as adjusted from time to time as provided in the Indenture.

 All terms used in this Security but not specifically defined herein are defined in the Indenture and are used herein as so defined. 

In the case of any conflict between the provisions of this Security and the Indenture, the provisions of the Indenture shall control. 

This Security shall not be valid until an authorized signatory of the Trustee manually signs the certificate of authentication on this
Security. 
 THE INDENTURE AND THIS SECURITY, AND ANY CLAIM, CONTROVERSY OR DISPUTE ARISING UNDER OR RELATED TO THE INDENTURE OR THIS
SECURITY, SHALL BE GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH, THE LAWS OF THE STATE OF NEW YORK. 
 The Company will furnish to any
Holder, upon written request and without charge, a copy of the Indenture. Requests may be made to: Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, Attention: Chief Financial Officer. 

  
 A-8 












 ABBREVIATIONS AND DEFINITIONS 

Customary abbreviations may be used in the name of the Holder or an assignee, such as: 

TEN COM (= tenants in common) 

TEN ENT (= tenants by the entireties) 

JT TEN (= joint tenants with right of survivorship and not as tenants in common) 

CUST (= Custodian) 
 UGMA (=
Uniform Gifts to Minors Act). 
 Additional abbreviations may also be used though not in the above list. 

  
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 ASSIGNMENT FORM 

To assign this Security, fill in the form below: 
 I or we
assign and transfer this Security to: 
  
  

 
  

(Insert assignee’s social security or tax I.D. number) 
  

 
  

 
  

 
  

 
  

 
  

 
  

 
  

 
 (Print or type assignee’s name, address and zip
code) 
 and irrevocably appoint 
  

 
  

 
 agent to transfer this Security on the books of the
Company. 
 The agent may substitute another to act for him or her. 

In connection with any transfer of the within Security occurring prior to the Resale Restriction Termination Date, as defined in the Indenture governing such
Security, the undersigned confirms that such Security is being transferred: 
 ☐ To Amyris, Inc. or any subsidiary of Amyris, Inc.; or 

☐ Pursuant to a registration statement that has become effective under the Securities Act of 1933, as amended; or 

☐ To a Person that is reasonably believed to be a “qualified institutional buyer” (as defined in Rule 144A under the Securities Act of 1933)
that is purchasing for its own account or for the account of another qualified institutional buyer and to whom notice is given that the transfer is being made in reliance on Rule 144A under the Securities Act of 1933, as amended, all in compliance
with Rule 144A under the Securities Act of 1933, as amended (if available); or 
 ☐ Pursuant to an exemption from registration provided by Rule 144
under the Securities Act of 1933, as amended (if available) or any other available exemption from the registration requirements of the Securities Act of 1933, as amended. 

  
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	Date:	  	Your Signature
	  
	  	  

		  	(Sign exactly as your name appears on the other side of this Security)

  

	*	 Signature guaranteed by: 



 

			
	By:	 	
                     
 


  

	*	 The signature must be guaranteed by an institution which is a member of one of the following recognized
signature guaranty programs: (i) the Securities Transfer Agent Medallion Program (STAMP); (ii) the New York Stock Exchange Medallion Program (MSP); (iii) the Stock Exchange Medallion Program (SEMP); or (iv) such other guaranty program
acceptable to the Trustee. 



  
 A-11 












 CONVERSION NOTICE 

To convert this Security into cash, shares of Common Stock or a combination of cash and shares of Common Stock, as applicable, check the
box:  ☐ 
 To convert only part of this Security, state the principal amount to be converted (which must be $1,000 or an integral multiple
of $1,000): $ 
 If you want the stock certificate made out in another Person’s name, fill in the form below: 

 
  
  

 
 (Insert assignee’s social security or tax I.D.
number) 
  
  

 
  
  

 
  

 
  

 
  

 
  

 
  

 
 (Print or type assignee’s name, address and zip
code) 
  

			
	Date:	  	Your Signature
	  
	  	  

		  	(Sign exactly as your name appears on the other side of this Security)

  

	*	 Signature guaranteed by: 



 

			
	By:	 	
                     
 


  

	*	 The signature must be guaranteed by an institution which is a member of one of the following recognized
signature guaranty programs: (i) the Securities Transfer Agent Medallion Program (STAMP); (ii) the New York Stock Exchange Medallion Program (MSP); (iii) the Stock Exchange Medallion Program (SEMP); or (iv) such other guaranty program
acceptable to the Trustee. 



  
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 REPURCHASE EXERCISE NOTICE UPON A FUNDAMENTAL CHANGE 

To: Amyris, Inc. 
 The undersigned registered
owner of this Security hereby irrevocably acknowledges receipt of a notice from Amyris, Inc. (the “Company”) as to the occurrence of a Fundamental Change with respect to the Company and requests and instructs the Company to
repurchase the entire principal amount of this Security, or the portion thereof (which is $1,000 or an integral multiple thereof) below designated, in accordance with the terms of the Indenture referred to in this Security at the Fundamental Change
Repurchase Price, to the registered Holder hereof. 
  

			
	Dated: ___________________________________	  	
		
		  	Signature(s)
		
		  	Signature(s) must be guaranteed by a qualified guarantor institution with membership in an approved signature guarantee program pursuant to Rule 17Ad-15 under the Securities Exchange Act of
1934.
		
		  	  

		  	Signature Guaranty

 Principal amount to be repurchased 

(in an integral multiple of $1,000, if less than all): 
 NOTICE:
The signature to the foregoing Election must correspond to the name as written upon the face of the Security in every particular, without alteration or any change whatsoever. 

  
 A-13 












 SCHEDULE OF EXCHANGES OF SECURITIES 

The initial principal amount of this Global Security is _______ DOLLARS ($[_________]). The following increases or decreases in this Global
Security have been made: 
  

									
	 Date of

Exchange,
 Repurchase
or
 Conversion
	 	 Amount of

Decrease in

Principal
 Amount of

this Global

Security
	 	 Amount of

Increase in

Principal
 Amount of

this Global

Security
	  	 Principal

Amount of
 this
Global
 Security

Following
 Such
Decrease
 or Increase
	  	 Signature of

Authorized
 Signatory
of
 Securities

Custodian



  
 A-14