EXHIBIT 31.1



CERTIFICATION OF PRINCIPAL EXECUTIVE OFFICER

PURSUANT TO EXCHANGE ACT RULES 13a-14(a)
AND 15d-14(a),

AS ADOPTED PURSUANT TO

SECTION 302 OF THE SARBANES-OXLEY ACT
OF 2002



I, Michael Scott Maguire, certify that:



| | 1. | I have reviewed this Amendment No. 1 to the Annual Report on Form 10-K of Xenetic Biosciences, Inc.;
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| | 2. | Based on my knowledge, this report does not contain any untrue
                                         statement of a material fact or omit to state a material fact necessary to make the statements
                                         made, in light of the circumstances under which such statements were made, not misleading
                                         with respect to the period covered by this report;
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| | 3. | Based on my knowledge, the financial statements, and other financial
                                         information included in this report, fairly present in all material respects the financial
                                         condition, results of operations and cash flows of the registrant as of, and for, the
                                         periods presented in this report;
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| | 4. | The registrant’s other certifying officer and I are responsible
                                         for establishing and maintaining disclosure controls and procedures (as defined in Exchange
                                         Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as
                                         defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:
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| | a. | Designed such disclosure controls and procedures, or caused
                                         such disclosure controls and procedures to be designed under our supervision, to ensure
                                         that material information relating to the registrant, including its consolidated subsidiaries,
                                         is made known to us by others within those entities, particularly during the period in
                                         which this report is being prepared;
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| | b. | Designed such internal control over financial reporting, or
                                         caused such internal control over financial reporting to be designed under our supervision,
                                         to provide reasonable assurance regarding the reliability of financial reporting and
                                         the preparation of financial statements for external purposes in accordance with generally
                                         accepted accounting principles;
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| | c. | Evaluated the effectiveness of the registrant’s disclosure
                                         controls and procedures and presented in this report our conclusions about the effectiveness
                                         of the disclosure controls and procedures, as of the end of the period covered by this
                                         report based on such evaluation; and
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| | d. | Disclosed in this report any change in the registrant’s
                                         internal control over financial reporting that occurred during the registrant’s
                                         most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case
                                         of an annual report) that has materially affected, or is reasonably likely to materially
                                         affect, the registrant’s internal control over financial reporting; and
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| | 5. | The registrant’s other certifying officer and I have disclosed,
                                         based on our most recent evaluation of internal control over financial reporting, to
                                         the registrant’s auditors and the audit committee of the registrant’s board
                                         of directors (or persons performing the equivalent functions):
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| | a. | All significant deficiencies and material weaknesses in the
                                         design or operation of internal control over financial reporting which are reasonably
                                         likely to adversely affect the registrant’s ability to record, process, summarize
                                         and report financial information; and
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| | b. | Any fraud, whether or not material, that involves management
                                         or other employees who have a significant role in the registrant’s internal control
                                         over financial reporting.
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Dated: April 29, 2016



By: /s/ Michael Scott Maguire

Michael Scott Maguire

Principal Executive Officer, President
and Director