This paper proposes a Bayesian counterpart to the widespread univariate analysis, taking into account the compositional character of a metabolome. Since each metabolome is a collection of some small-molecule metabolites in a biological material, the relative structure of metabolomic data, which is inherently contained in ratios between metabolites, is of the main interest. Therefore, a proper choice of logratio coordinates is an essential step for any statistical analysis of such data. In addition, a concept of b-values is introduced together with a Bayesian version of the volcano plot incorporating distance levels of the posterior highest density intervals from zero. The theoretical background of the contribution is illustrated using two data sets containing samples of patients suffering from 3-hydroxy-3-methylglutaryl-CoA lyase deficiency and medium-chain acyl-CoA dehydrogenase deficiency. To evaluate the stability of the proposed method as well as the benefits of the compositional approach, two simulations designed to mimic a loss of samples and a systematical measurement error, respectively, are added.

Deng, X., Feng, J., Pan, S., Wang, Z., Zhang, J., Chen, W., 2020. An improved model for the migration of fluids caused by hydrate dissociation in porous media. Journal of Petroleum Science and Engineering 188, 106876.

http://www.sciencedirect.com/science/article/pii/S0920410519312926 Natural gas hydrates may be the world's future resources, but extracting from the reservoirs involves accurately understanding the transport mechanism of the fluids caused by hydrate dissociation. In this paper, based on Darcy's unsaturated soil mechanics theory, we establish a coupling model of two-phase flow and heat transfer caused by hydrate dissociation, which considering methane gas compressibility and capillary force naturally. The new model is validated through Masuda's test dataset, and notably, the experimental phenomenon of the small peak in the gas pressure of the far-end boundary (Run 4) is reproduced for the first time. Additionally, an implicit function of pore pressure and time in the initial stage of hydrate dissociation is deduced to interpret the in-situ pore accumulation of the gas generated in dissociation, which leads to a more comprehensive description of the migration mechanism of hydrate reservoir fluids. Furthermore, the initial hydrate saturation of the Run 4 sample in Masuda's test is proved to be closer to 0.501 instead of 0.443 that the author reported, which can help Masuda's test dataset being a benchmark for the hydrate dissociation researching in future. Thus, this work provides further insight into the migration mechanism of the gases caused by hydrate dissociation and services practical support for efficiently and safely extracting methane gas from the hydrate reservoirs.

Deng, X., Kamal, M.S., Patil, S., Hussain, S.M.S., Zhou, X., 2020. A review on wettability alteration in carbonate rocks: Wettability modifiers. Energy &Fuels 34, 31-54.

https://doi.org/10.1021/acs.energyfuels.9b03409 More than half of the global oil reserves are in carbonate reservoirs. Carbonate rocks, however, in most cases tend to be mixed-wet or oil-wet. Wettability alteration of carbonate reservoir rock has been proven to increase oil recovery significantly. Several chemicals have shown their effect on wettability; however, selection of an appropriate wettability modifier should be made on the basis of the underlying mechanisms and their behavior at reservoir conditions. This review discusses techniques that can help in assessing wettability alteration or reflect on the underlying mechanism and describes several categories of wettability modifiers focusing on their structure - property relationship and factors affecting their performance at reservoir conditions. Surfactants, nanoparticles, salts, and alkalis are four major categories of wettability modifiers that are discussed in this review. Among surfactants, gemini surfactants have great potential and could be a major focus of future research in this area. Nanoparticles are relatively novel materials for wettability alteration with the capability to reduce contact angle significantly at low cost. This review also identifies the current and future challenges related to the performance of various wettability modifiers at high-temperature and high-salinity conditions.

Dhakal, S., Gupta, I., 2020. Predictive modeling of thermogenic methane hydrate formation and geobody distribution - Results from numerical simulations. Journal of Natural Gas Science and Engineering 75, 103154.