# Job Post & Description: Postdoctoral Researcher

Prof. Roger Geiger (Systems Immunology Lab)

Bellinzona, Switzerland

## Institute for Research in Biomedicine (Istituto di ricercia in biomedicine) (IRB)

The Institute for Research in Biomedicine (IRB) is a center of excellence for research in human immunology, with an emphasis on the mechanisms underlying host defenses against cancer, autoimmunity and infectious disease. We recently moved into a new, state-of-the-art facility equipped with advanced technologies including mass-spectrometry, flow cytometry, microscopy and genomic core facilities. Located in the Italian-speaking region of southern Switzerland, the IRB is centrally placed between Zurich and Milan with immediate access to the Alps. Bellinzona is famous for its three medieval castles, which provide a stunning backdrop for researchers performing cutting edge science.

## Geiger Lab, Istituto di ricercia in biomedicina (IRB)

The Geiger lab employs a variety of approaches including mass spectrometry-based proteomics, functional genetics, and microfluidics-based applications centered around studying T cell biology in the context of cancer. We recently engineered bacteria to recycle metabolic waste products to promote anti-tumor T-cell responses (Canale et al., Nature 2021), applied quantitative systems-level proteomics to reveal a dynamic program of protein turnover in human T cells (Wolf et al., Nature Immunology 2020), and are currently developing CRISPR screening platforms to interrogate genetic determinants of cancer cell resistance to CAR-T cell predation. For more information, visit: https://www.geigerlab.org/

## Opportunity

The Geiger lab is recruiting a postdoctoral researcher to lead a project(s) investigating cancer-immune cell interactions. We are seeking a highly motivated candidate excited to explore the intersection of immunology, cancer cell biology, immunotherapy and genome engineering. The applicant should help foster a creative, cooperative, and collaborative research group.

## Scope of Work

The postdoc will be performing mouse studies, culturing primary immune and cancer cells, executing functional assays using novel CRISPR-based technologies, conducting fluorescence activated cell sorting (FACS) to analyze cellular phenotypes, as well as leveraging mass-spectrometry based proteomics and genetic, epigenetic and transcriptional analyses using next-generation sequencing (NGS).

Required Qualifications:

- • or MD/PhD in immunology, cell biology or a related field • or MD/PhD in immunology, cell biology or a related field
- • experience with tumor mouse models • experience with tumor mouse models
- • experience with flow cytometry, mass-spectrometry, molecular biology, NGS and • experience with flow cytometry, mass-spectrometry, molecular biology, NGS and computational biology
- • to work independently & cooperatively • to work independently & cooperatively
- • interpersonal communication skills (written & verbal) • interpersonal communication skills (written & verbal)
- • to prioritize tasks, coordinate with others and meet multiple deadlines • to prioritize tasks, coordinate with others and meet multiple deadlines

Preferred Qualifications:

- • with statistical analyses of high-dimensional / omics data in R and/or Python • with statistical analyses of high-dimensional / omics data in R and/or Python
- • track record of first-author publications • track record of first-author publications

## Expected period of performance

The contract is for 2 years, with the possibility of extension.