may range from an initial 5 mcg up to 20 mcg/ml, increasing the gas volume progressively from 150 ml to 450 ml in 2 weeks The other methods, depending upon the stage of the disease, require two cycles (of 14-20 treatments each) per year with at least one monthly treatment as maintenance in between. Chronic limb ischaemia is often accompanied by an ulcer that will never heal unless we normalize the delivery of oxygen and stimulate tissue regeneration. In this disease, ozone delivers its best messages and behaves really as a wonderful drug when the ozonetherapist combines the ozonated AHT with domiciliary topical therapy with ozonated oil. The local induction and release of growth factors in a sterile and revascularized tissue has a fundamental importance for the healing process. The disappointing clinical outcome from growth factor trials (Bennett et al., 2003) is due to the fact that exogenous hormones applied on an infected and ischaemic tissue are useless. Almost needless to say that the patient must continue the basic conventional therapy that aims to block the progression of the disease.

It seems to us that, although ozone therapy is a fairly unknown and boycotted (by orthodox ophtalmologists) complementary medical approach, it should not be viewed with scepticism and, with the limitations objectively discussed above, deserves to be applied in suitable patients, Even though they regain only a fraction of their original visual acuity, when there is NO OTHER USEFUL TREATMENT, patients are greatly appreciative as demonstrated by an excellent compliance along the years.

Neurodegenerative disorders affect about 50 million people in the world and have a terrific and increasingly negative social-economic impact on families and society. While a better understanding of degenerative events may allow devising medical therapies able to slow down the demise of critical populations of neurons, we should not disregard the corroborant effect of ozone therapy particularly in the early stage of the disease. If ozone therapy is endowed with the capacity of mobilizing BMSC or activating dormant SC in the brain, we may be able to drastically change a gloomy prognosis. At the least patients have only to gain a better quality of life by associating useful medical therapies to ozone therapy.

In the last few years, I have made an effort to explain that ozone therapy, by triggering different mechanisms of action, may be able to create an environment hostile to cancer cells (Bocci, 1988c). This is a new line of thought stating that the cell malignancy can be tamed through the use of a multiform biological modifier. The rationale of the approach, a possible timing of application, either alone in patients with minimal residual disease or in combination with orthodox treatments and the already used therapeutic scheme have been described in details.

The dysmetabolic syndrome is recognized as one of the most serious disease in Western countries caused by a number of metabolic alterations such as type 2 diabetes, hypercholesterolaemia, atherosclerosis, renal dysfunction with the common denominator represented by a chronic oxidative stress. Although orthodox medicine has several good drugs for blocking the progression of diabetes and atherosclerosis, it continues to ignore the