The discovery that nephropathies are progressively worsened by a state of oxidative stress not yet controllable by orthodox medicine compels me to strongly advise the application of ozone therapy either in acute, chronic and terminal stage of the disease. I hope that nephrologists will endorse this idea and test this new approach. The real possibility of controlling the hyperoxidative state and inducing a feeling of wellness are eloquent and encouraging advantages. The study of gene and stem-cell biology is most important and likely will produce amazing therapeutic innovations but, realistically, growing replacement organs is still a long way off (Soares, 2004). As renal transplantation is still unable to satisfy the global need, what is wrong in trying to help patients with ozone therapy? I honestly cannot justify the obstracism of orthox medicine and the the negligence of Health Authorities in disregarding the beneficial help of this approach. I remain faithful to the concept that only the combination of treatments is the best way to correct the multiform derangements typical of chronic diseases.

There are rational bases for entertaining the application of ozone therapy in dermatological diseases such as psoriasis and atopic dermatitis. However, orthodox medicine, thanks to colossal commercial enterprises, has made available new interesting drugs, which are effective but not totally devoid of risks. This is one reason for dermatologists to obstruct the evaluation of ozone therapy with the consequent difficulty of recruiting patients for clinical studies. Moreover patients with these diseases are often very distressed and understandably anxious to receive the most effective treatment immediately. Ozonetherapy may yield some benefit at a slow pace and patients will accept it only if, at least in the initial period, they are assisted with the proven topical drugs. On the other hand, the use of ozonated water and oil for chronically infected wounds and ulcers yields wonderful results and official medicine will have, sooner or later, to acknowledge the value of ozone in these dermatological affections, which worry so much diabetics and old people.

I have reviewed a good clinical study, meaningful assumptions and a few anecdotal hints for justifying the use of ozone therapy in asthma, COPD, IPF, ARDS, and emphysema. It is felt that ozone therapy could act as a synergistic adjuvant when combined to orthodox therapy. The acceptance of this proposal will imply reduction of medical and social costs but, above all, a better and longer life for many patients. It is unbelievable and regrettable that the medical establishment and World Health Authorities remain sceptical and do not help evaluating the application of ozone therapy.

Familiarity (hence, genetic factors), age and sex and an extremely variable number of causes are responsible for tinnitus and SHL. If vascular defects were predominant, we ought to have noted an improvement in at least a few patients. It is however possible that, once the symptoms appeared, the lesions are either already irreversible or cannot be modified by ozone therapy. To my knowledge, ozone therapy had not been evaluated before in these pathologies and I will be grateful to exchange information with anyone more knowledgeable