treated reasonably well with either antiviral drugs or ozonetherapy. However, for the many patients, who suffer more or less frequently of these affections, this is an unsatisfactory information because they only want to know which is the most rapid and effective treatment. It would be a great advancement if we could programme a comparative study including three arms:

antivirals, ozonetherapy and both. Such a huge study involves hundreds of patients, many clinicians and great resources for various analyses and it is beyond our possibility. Only imaginative public-health leaders could undertake this endeavour but do they exist?

Meantime the solution that may yield the best and lasting result (if not the cure) can be obtained by COMBINING the orthodox antiviral agents with ozonated major plus minor autohaemotherapy and topical application of ozonated oil. Genital herpes is the infection that often causes severe psychological effects and the majority of patients feel devastated when they learn the diagnosis. This is the reason why I strongly recommend a combination therapy carried out for a prolonged period and likely to reduce recurrency and the risk of transmission.

It can be said that ozone, in spite of its potent disinfectant activity in vitro, is NOT as active in vivo because pathogens are normally protected by the plasma and cellular antioxidants. This point must be emphasized to prevent the direct intravenous administration of gas into patients practised by quacks, which often leads to deadly oxygen embolism. Nevertheless ozone can be useful in infectious diseases by activating ancillary mechanisms. Luckily orthodox medicine has made available a number of antivirals, which, when used in COMBINATION, are effective (but not always curative) in rapidly clearing viruses from the plasma and cells. Unfortunately the hope to eradicate the HIV has not come true and, at this point, ozonetherapy can become useful because it is able to activate several biochemical and immunological pathways that eventually may further reduce the morbidity. This is a realistic vision that regretfully is not shared by orthodox infectivologists but it is hoped that the tendency of treating chronic and complex diseases with reductionist approaches will vanish when clinicians will become convinced of the effectiveness and atoxicity of ozonetherapy. What is at stake is not the validity of one or the other approach but the wellbeing of the patient!

A combination of the basic orthodox medicine and a life-long prolongation of ozone therapy is potentially able to correct the chronic oxidative stress underlying the vascular disease and restore health in seriously ill-patients. This is due to the multiform and simultaneous effects elicited by ozone therapy, a virtue not shared by other approaches. Patients are very much interested to know which will be the best and simple course for taking full advantage of ozone therapy. Among the described approaches

AHT, RI, BOEX and the “gluco-peroxide”infusion are the least invasive, well tolerated and absolutely atoxic in the long term. RI is the least expensive and the instructed patient can do it at home. In such a case, ozone concentrations