Zokie of Planet Ruby: Quirky 10-year-old vlogger Ruby discovers her only video channel follower is a tail-zapping space alien from the planet Pudge named Zokie Sparkleby, and they quickly become best friends. Along with their friend Earl, a talking con-man squirrel, Ruby teaches Zokie about her version of Earth, while Zokie learns to control his unpredictable powers.

Ruby: Ruby is a bubbly 10 year old girl who is determined to make it big as a vlogger under the name "Planet Ruby". She is friendly to everyone she meets and is always willing to cheer up anyone who feels down. Ruby cares a lot for her peers, but also sometimes feels like she isn't appreciated enough. Before Zokie arrived, she spent most of her time alone since she had nobody to hang out with. She wants to be liked by her classmates but worries that she's too weird - but this doesn't stop her from trying to make friends. She describes herself as a weirdo.

Zokie: Zokie comes from the alien planet named "Planet Pudge", where he serves King Pootywinkle as his sandwich maker. Zokie is gullible and naive, which leads him to believing most words at face value - however, this doesn't stop him from having a great time. He is eager to help his best friend Ruby, and uses his alien gadgets to solve any problem; and though his intentions are always right, his results are sometimes unexpected. Zokie is very close to Ruby and he feels very sad leaving her every Earth night to return to Planet Pudge. He struggles to say some English words such as 'Leprechaun'.

Earl: Earl is a lazy and selfish squirrel who lives in a tree in the front yard of Ruby's house. He is described to be a rude con man, who frequently becomes unwillingly involved in Ruby and Zokie's plans for internet stardom. He often acts as the "third wheel" of their friendship, and likes to steal items in order to sell them so he can be rich.

Tweenkle: Tweenkle is a bratty tweenaged girl who makes awesome online videos. She is the rival of Ruby. She lives in a large mansion on the same street as her rival Ruby's house. She is a tween celebrity known for her online video channel, which has millions of subscribers. Her videos usually involve makeup tutorials, talking with lots of cat pictures and airhorn sound effects.
Tweenkle is bratty and vain, possibly due to her riches and success with social media. She wants to be the center of attention at all times and is irritated at the thought of somebody surpassing her follower count online. Tweenkle usually looks down on Ruby and Zokie because their channel is much less successful than hers.

King Pootywinkle: King Pootywinkle is the strict yet cute king of Planet Pudge. All the aliens on the planet work for him to make sure he is pleased, and those who fail to please him are punished accordingly. His followers worship him and aim to make him happy at all costs.
King Pootywinkle's aim on earth is to bring Zokie back to Planet Pudge, because Zokie was his sandwich maker. King Pootywinkle has a small and fluffy appearance, but that doesn't stop him from being tough. He is whiny and complains due to his incredibly high standards. He comes off as spoiled, having everything he wants given to him without doing much for it. He does not show any signs of manners or gratefulness, and fails to see his servants as individuals.