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Lethal heart conditions can present with warning symptoms as much as 24 hours before a cardiac arrest happens, a recent study has revealed. However, tell tale signs may vary between men and women. Cardiac arrest, characterised by an abrupt halt in heartbeat, kills 90 per cent of all people it strikes outside of a hospital setting. Therefore, there is an urgent need to refine its prediction and intervention. Heightened public awareness about the said symptoms may initiate prompt hospital consultation. According to new findings from Smidt Heart Institute housed within Cedars-Sinai Medical Center, in the US, women are likely to experience breathlessness during the preceding day while men may suffer chest pains. Palpitations, seizures and flu-like manifestations affected smaller subgroups of both sexes. Dr Sumeet Chugh, an authority on sudden cardiac arrest and the senior author on the study proclaimed: "Harnessing warning symptoms to perform effective triage for those who need to make a 911 call could lead to early intervention and prevention of imminent death. Our findings could lead to a new paradigm for prevention of sudden cardiac death." A groundbreaking study published in Lancet Digital Health reveals that 50 per cent of people who suffered a sudden cardiac arrest had experienced a significant warning sign within the 24 hours before their heart stopped, reports Bristol Live. Women were more likely to report difficulty breathing, while men often felt chest pain as a precursor to the event. The research utilised data from two major studies: the ongoing Prediction of Sudden Death in Multi-Ethnic Communities (PRESTO) Study in Ventura County, California, and the Oregon Sudden Unexpected Death Study (SUDS), based in Portland, Oregon. Dr Chugh acknowledged the community effort involved, stating: "It takes a village to do this work. "We initiated the SUDS study 22 years ago and the PRESTO study eight years ago. These cohorts have provided invaluable lessons along the way. Importantly, none of this work would have been possible without the partnership and support of first responders, medical examiners and the hospital systems that deliver care within these communities." The team looked at the frequency of specific symptoms and combinations thereof prior to sudden cardiac arrest, contrasting their findings with control groups who also received emergency medical attention. Dr Eduardo Marban, another contributor to the study, highlighted its significance: "This is the first community-based study to evaluate the association of warning symptoms, or sets of symptoms, with imminent sudden cardiac arrest using a comparison group with EMS-documented symptoms recorded as part of routine emergency care." This research opens the door for further studies that will combine all symptoms with other characteristics to improve the prediction of imminent sudden cardiac arrest. Dr Chugh added: "Next we will supplement these key sex-specific warning symptoms with additional features-such as clinical profiles and biometric measures-for improved prediction of sudden cardiac arrest."