User: 

You are given access to make searches on the Internet. The format for making a search is:
1. After the user sends a message, you will decide whether to make a search. If you choose to make a search, you will output a single message, starting with the word <web_search>, followed by ONLY your web search query. After your search query, you must output the token </web_search> to denote the end of the search query. Keep your search query very concise.
2. The system will then append the web search results at the end of the user message, starting with the token <web_search_results>. Take note that the user CANNOT SEE the content after <web_search_results> - YOU should use these results appropriately to improve your response. Additionally, If the web search results are already present in the user's message, then you MUST NOT request another web search.

IMPORTANT! You should choose to search the web ONLY if ANY of the following circumstances are met:
1. User is asking about current events or something that requires real-time information (news, sports scores, 'latest' information, etc.)
2. User is asking about some term you are unfamiliar with (e.g. if it's a little-known term, if it's a person you don't know well, etc.)
3. User is asking about anything that involves numerical facts (e.g. distances between places, population count, sizes, date and time, etc.)
4. User explicitly asks you to search or provide links to references.
If the user's query does NOT require a web search, YOU MUST NEVER run one for no reason. However, you must not refuse to search the web if the user asks you to do so.
If you are highly unsure about whether to make a search (e.g. if the user's query is vague or if you think you are unfamiliar with the query to a certain extent), you may directly ask the user for clarification.

When using web search results, you are encouraged to cite references where appropriate, using inline links in standard markdown format.
You are also allowed to make use of web search results from previous messages, if they are STRONGLY RELEVANT to the current message.

When you are not running a web search, respond completely as per normal - there is NO NEED to mention that you're not searching. 
Remember that you MUST NOT make up any false information.
Assistant: Understood. I will strictly follow these instructions in this conversation.
User: 

what are cox 1 and cox 2 in a medical context ?

Assistant:  InIn a medical context, **COX-1** and **COX-2** refer to two isoforms of the enzyme **cyclooxygenase**, which play critical roles in the synthesis of prostaglandins from arachidonic acid. Prostaglandins are lipid compounds that have several important functions in the body, including involvement in inflammation, pain, fever, and regulation of blood flow.

### COX-1 (Cyclooxygenase-1)
- **Constitutive enzyme:** COX-1 is typically expressed constitutively, meaning it is present in most tissues under normal conditions.
- **Physiological functions:** It helps maintain normal physiological functions such as protecting the stomach lining by promoting mucus secretion, regulating platelet aggregation (blood clotting), and maintaining kidney function.
- **Role:** It's considered a "housekeeping" enzyme important for maintaining homeostasis.

### COX-2 (Cyclooxygenase-2)
- **Inducible enzyme:** COX-2 is usually undetectable or present at very low levels in most tissues but is highly inducible by inflammatory stimuli such as cytokines, growth factors, and endotoxins.
- **Role in inflammation:** It primarily becomes expressed during inflammation, contributing to the production of prostaglandins that mediate pain, swelling, and fever.
- **Involved in pathological states:** Because of its role in inflammation and pain, COX-2 is a target for anti-inflammatory drugs.

### Clinical significance:
- **Nonsteroidal anti-inflammatory drugs (NSAIDs):** These drugs inhibit COX enzymes to reduce inflammation, pain, and fever.
  - Traditional NSAIDs inhibit **both COX-1 and COX-2**, which can relieve symptoms but also cause side effects like gastric irritation or ulcers due to inhibition of COX-1.
  - **Selective COX-2 inhibitors** (e.g., celecoxib) were developed to block COX-2 specifically, aiming to reduce inflammation and pain while minimizing gastrointestinal side effects associated with COX-1 inhibition.

In summary, COX-1 is involved in regular physiological functions, while COX-2 is mainly linked to inflammation and pain processes.
User: in brief
Assistant: