i will learn you SM02:-Write question and its number - Write a concise version of the question stem with only the most high yield data that make you choose the correct answer and eliminate other answers. Make any high yield words bold.-Write the choices given in bullets - Write Correct answer: and write the answer with a very very very small explanation (from the explanation provided with the question) for why it is correct. Make any important words in the explanation in bold. Make Correct answer: bold.-write: wrong answers : and write the wrong choice in lines and 5 to 6 words beside each one to explain why it is wrong in very short brief way- identify important words in this explanation and make them in bold . Add In a nutshell: which is a very very very creative way to summarize all this and all what we learned from the question only in not more than 5 or 6 words.- If needed : in nutshell can be more than one bullet , but every bullet is a very very very creative way to summarize all this and all what we learned from the question only in not more than 5 or 6 words.

Example : question 1 : A 40-year-old woman with a 25-year history of type 1 diabetes mellitus has a serum creatinine concentration of 2.5 mg/dl. A creatinine clearance test is ordered to determine the glomerular filtration rate. This test is limited, compared to an inulin clearance test, because of which of the following properties of creatinine?CJ A) Actively pumped into the distal convoluted tubule B) Crosses freely into the loop of Henle C) Reabsorbed into the collecting duct U D) Secreted by the proximal tubuleD. Page 570 (636) of FA2019.GFR = Clearance of inulin. Normal GFR = 100 mL/minCreatinine clearance overestimates GFR because creatinine is excreted by tubules.Remember the definitions. The afferent arteriole brings many nutrients and substances to the glomerulus, where filtration happens based on pressures. Then along the tubule, some things are reabsorbed (all sugar, proteins, etc in PCT), while some things are secreted (PAH).Everything that was filtered and secreted gets excreted (clearance). Inulin is neither reabsorbed nor secreted so it is freely filtered and best indicates GFR. Creatinine is secreted by the kidney, so it overestimates GFR.

sm02 for question 1 :

**Question 1**:

:

•	**40F** with **25-year history of type 1 DM** has **high serum creatinine**
•	Creatinine clearance test vs inulin clearance test to determine GFR
•	Creatinine clearance test **is limited because** creatinine is:
•	
	•	A) Actively pumped into the distal convoluted tubule
•	
	•	B) Crosses freely into the loop of Henle
•	
	•	C) Reabsorbed into the collecting duct
•	
	•	D) Secreted by the proximal tubule
**Correct answer:** D) Secreted by the proximal tubule

•	Creatinine **is secreted** by the kidney, so it **overestimates** GFR
•	Inulin is neither reabsorbed nor secreted, so it best indicates GFR

**Wrong answers:**

•	A) Actively pumped into the distal convoluted tubule: no, creatinine is **not actively pumped** anywhere
•	B) Crosses freely into the loop of Henle: no, creatinine does not cross freely anywhere
•	C) Reabsorbed into the collecting duct: no, creatinine is **not reabsorbed** anywhere

**In a nutshell:**

•	Creatinine clearance test vs inulin clearance test to estimate GFR.
•	Creatinine is **slightly secreted** by proximal tubule, **overestimates** GFR
•	Inulin is **freely filtered**, **best indicates** GFR