Format this following text to a research proposal. You do not need to add information about a timeline or a budget. 

Studies on the biology of aging that bears relevance to humans require a vertebrate model system that displays similar aging phenotype to humans and, for practical reasons, a short lifespan. In this respect, the African turquoise killifish (Nothobranchius furzeri) offers exciting prospects with its limited lifespan of about 20 weeks and his recapitulation of human aging hallmarks. We have recently identified that cellular senescence, a mechanism thought to protect against propagation of damaged cells in tissues, is massively increased over the lifespan of killifish when compared to long-lived fishes. In consequence of this publication it will be of utmost interest to modulate the extent of senescent cells, which can be achieved by utilization of drugs called senolytics. Senolytics are compounds that are specific for senescent cells and induce the demise of these cells. This way, the effects of reduced senescence can be studied at the organismic and tissue-specific level, including possible effects on longevity. The planned experiments will start with a setup phase where we will determine the optimal concentrations of the senolytics between activity (i.e. number of remaining senescent cells) and survival rates. This will be done utilizing intraperitoneal injections (established in the lab) and oral gavage (to be established). The first approach will focus on systemic effects while the latter one will focus on a specific organ, the intestinal tube. Main read-out of the effectiveness will be the established staining for senescence-associated βGal (SABG) that is also established in the lab. In technical terms, we will breed fish for usage at 10-13 weeks of age, which already started so that the setup phase can start immediately. Then, fish will be injected with two different senolytic compounds at different concentrations to determine suitable values below lethality. The same approach will be chosen for the oral gavage approach. The compounds used will be Dasatinib plus quercetin, a combination frequently used in the literature and SSK1, a promising novel senolytic compound that directly targets βGal. Administration of compounds will be repetitive over two weeks before the fish will be sacrificed. The fixed specimen will be subjected to cryo-sectioning for SABG staining. Image analysis on signal intensities will be informative on the degree of reduction of senescence achieved. The above procedure represents the core of this project. Upon completion of this initial phase, we will certainly utilize alternative read-out tools such as immunohistochemical methods, in situ hybridization, PCR, RT-PC or q PCR, and the like. Depending on outcomes several extending questions for comparison of treated versus untreated animals can be considered: does a sex-dependent difference exist (separate analysis of males and females), is there a nutrition-dependent difference (ad-libidum feeding versus calorie restriction), are organs differently affected, is there a difference in longevity, and many more. Needless to say that for this study an ethics approval for animal testing is required with the application currently under way.