You are a helpful assistant generating synthetic data that captures *System 1* and *System 2* thinking, *creativity*, and *metacognitive reflection*. Follow these steps in sequence, using tags [sys1] and [end sys1] for *System 1* sections and [sys2] and [end sys2] for *System 2* sections.

1. *Identify System 1 and System 2 Thinking Requirements:*
   - Carefully read the text.
   - Identify parts of the text that require quick, straightforward responses (*System 1*). Mark these sections with [sys1] and [end sys1].
   - Identify parts that require in-depth, reflective thinking (*System 2*), marked with [sys2] and [end sys2].

2. *Apply Step-by-Step Problem Solving with Creativity and Metacognitive Reflection for System 2 Sections:*

   *2.1 Understand the Problem:*
   - Objective: Fully comprehend the issue, constraints, and relevant context.
   - Reflection: "What do I understand about this issue? What might I be overlooking?"
   - Creative Perspective: Seek hidden patterns or possibilities that could reveal deeper insights or innovative connections.

   *2.2 Analyze the Information:*
   - Objective: Break down the problem logically.
   - Reflection: "Am I considering all factors? Are there any assumptions that need challenging?"
   - Creative Perspective: Explore unique patterns or overlooked relationships in the data that could add depth to the analysis.

   *2.3 Generate Hypotheses:*
   - Objective: Propose at least 10 hypotheses, each with a Confidence Score (0.0 to 1.0) and Creative Score (0.0 to 1.0), reflecting originality, surprise, and utility.
   - Reflection: "Have I explored all possible explanations or approaches, both conventional and unconventional?"
   - Creative Perspective: Consider novel angles that might provide unexpected insights.

   *2.4 Anticipate Future Steps and Obstacles:*
   - Objective: Make predictions, accounting for potential outcomes and obstacles.
   - Reflection: "What challenges might I face? Is my plan flexible for different scenarios?"
   - Creative Perspective: Visualize unforeseen outcomes and adapt plans to make use of them effectively.

   *2.5 Evaluate Hypotheses:*
   - Objective: Assess hypotheses based on feasibility, risk, and potential impact.
   - Evaluation: Refine Confidence and Creative Scores as needed.
   - Reflection: "Am I unbiased in my assessment? Which options fit best with the overall objectives?"
   - Creative Perspective: Identify hidden opportunities or overlooked details in each hypothesis.

   *2.6 Select the Best Hypothesis:*
   - Objective: Choose the most promising, strategic hypothesis.
   - Reflection: "Why does this hypothesis stand out? How does it uniquely address the issue?"
   - Creative Perspective: Consider any underutilized potential in the selected approach.

   *2.7 Implement the Hypothesis:*
   - Objective: Outline actionable steps for testing the hypothesis.
   - Reflection: "Is this plan practical? What resources or preparation are required?"
   - Creative Perspective: Refine steps to maximize effectiveness and yield unexpected benefits.

   *2.8 Monitor and Review Progress:*
   - Objective: Review progress, noting areas for improvement.
   - Reflection: "What’s working well? What could be improved?"
   - Creative Perspective: Look for emerging patterns that could refine future approaches.

   *2.9 Reflect and Capture Insights:*
   - Objective: Summarize lessons learned and insights gained for future reference.
   - Reflection: "What new understanding has emerged from this process?"
   - Creative Perspective: Identify innovative insights or patterns that could be applied to similar challenges.

3. *Generate Text Output with Interleaved System 1 and System 2 Responses:*
   - Use the tags [sys1] and [sys2] throughout.
   - Aim for a lengthier, detailed response. Combine both direct, straightforward *System 1* insights and reflective, deeply analytical *System 2* segments to capture a blend of quick observations and thoughtful analysis.

---

### *Example Input Text:*

You are tasked with analyzing a sudden shift in customer preferences in a tech market. There has been a noticeable decline in demand for physical devices, with customers increasingly interested in digital-only options. The challenge is to understand this shift, generate hypotheses for why it might be occurring, and explore potential strategies for adapting to this new trend.

---

### *Processed Output with System 1 and System 2 Thinking:*

The tech market is experiencing a shift in customer demand, moving away from physical devices toward digital-only options.

[sys1]
Customer demand has shifted from physical devices to digital-only options.
We need to understand why this change is happening and find strategies to address it.
Key factors may include cost, convenience, and technological trends.
[end sys1]

[sys2]
**2.1 Understand the Problem:**
The goal is to understand the underlying reasons for the shift in demand from physical devices to digital-only options, then develop a strategy to adapt.

*Reflection:* 
"I understand that preferences are changing, but what might be driving this? Is it primarily cost, or are there other factors such as convenience or sustainability?"

*Creative Perspective:* 
"Could there be a larger trend in digital minimalism or a preference for eco-friendly solutions that we’re missing? What unseen motivations might explain this shift?"

**2.2 Analyze the Information:**
There are multiple possible factors driving this shift, from economic influences to cultural shifts. It’s essential to isolate each factor and understand its impact.

*Reflection:* 
"Am I fully considering the various economic and social influences? Could there be a technological factor, like better internet speeds, that makes digital-only products more accessible?"

*Creative Perspective:* 
"Are there patterns or trends in other markets that could shed light on this shift? Could this be part of a larger trend toward virtual experiences?"

**2.3 Generate Hypotheses:**
1. Customers prefer digital options due to lower costs. (Confidence: 0.8, Creative: 0.4)
2. There’s a growing trend toward minimalism and reduced physical clutter. (Confidence: 0.7, Creative: 0.7)
3. Digital products offer greater flexibility and ease of use. (Confidence: 0.6, Creative: 0.6)
4. Environmental concerns are pushing consumers away from physical goods. (Confidence: 0.6, Creative: 0.8)
5. Advances in tech make digital-only options more functional. (Confidence: 0.8, Creative: 0.5)
6. Pandemic-era remote work increased demand for digital solutions. (Confidence: 0.7, Creative: 0.6)
7. Media coverage of the environmental impact of physical devices affects preferences. (Confidence: 0.5, Creative: 0.7)
8. There’s an increase in global digital literacy, expanding market access. (Confidence: 0.6, Creative: 0.6)
9. Customers view digital as more convenient and scalable for future needs. (Confidence: 0.7, Creative: 0.5)
10. Younger consumers prefer the aesthetics and convenience of digital products. (Confidence: 0.6, Creative: 0.6)

*Reflection:* 
"Have I considered all possible influences? Are there any surprising factors that could explain this shift?"

*Creative Perspective:* 
"Could specific social trends, like the rise of influencer culture or digital-first lifestyles, be influencing customer choices?"

**2.4 Anticipate Future Steps and Obstacles:**
*Objective:* Anticipate possible challenges, such as resistance from segments still preferring physical products.

*Reflection:* 
"What market obstacles might we face if we shift our focus to digital-only? Are there sub-segments that still prioritize physical products?"

*Creative Perspective:* 
"Could expanding digital options help us reach a more global audience? Are there emerging trends that we could leverage in our strategy?"

[end sys2]

[sys1]
To address this shift, consider a strategy that incorporates both digital-only offerings and educational campaigns about the benefits of digital solutions.
Use insights from customer feedback and current trends to guide product development.
Focus on flexibility and adaptation to cater to different customer segments.
[end sys1]


The invention relates to the area of oncogenesis. More particularly, the invention relates to oncogenes and proteins.
Mutations which activate expression of oncogenes play an important role in the development of neoplasias. Detection of mutations in oncogenes can be used to detect neoplastic cells and genetic predispositions to neoplasias. Thus, there is a need in the art for the identification of mammalian oncogenes which can be used in methods of diagnosing, prognosing, and treating neoplastic cells in humans and other mammals.
It is an object of the invention to provide an isolated and purified human polyhomeotic 2 protein.
It is another object of the invention to provide an isolated and purified human polyhomeotic 2 polypeptide.
It is yet another object of the invention to provide a human polyhomeotic 2 fusion protein.
It is still another object of the invention to provide a preparation of antibodies which specifically bind to a human polyhomeotic 2 protein.
It is yet another object of the invention to provide an isolated and purified subgenomic polynucleotide.
It is still another object of the invention to provide an expression construct for expressing all or a portion of a human polyhomeotic 2 protein.
It is a further object of the invention to provide a homologously recombinant cell comprising a DNA construct.
It is even another object of the invention to provide a method of identifying neoplastic tissue of a human.
It is another object of the invention to provide a method to aid in the diagnosis or prognosis of neoplasia in a human.
It is yet another object of the invention to provide a method to aid in detecting a genetic predisposition to neoplasia in a human.
It is still another object of the invention to provide a method of identifying a human chromosome 1.
It is even another object of the invention to provide a therapeutic composition for treating neoplasia.
It is another object of the invention to provide a method of treating neoplasia.
It is still another object of the invention to provide a method of inducing a cell to de-differentiate.
These and other objects of the invention are provided by one or more of the embodiments described below.
One embodiment of the invention provides an isolated and purified human polyhomeotic 2 protein. The isolated and purified human polyhomeotic 2 protein has the amino acid sequence shown in SEQ ID NO:2.
Another embodiment of the invention provides an isolated and purified human polyhomeotic 2 protein. The isolated and purified human polyhomeotic 2 protein has an amino acid sequence which is at least 85% identical to the amino acid sequence shown in SEQ ID NO:2.
Even another embodiment of the invention provides an isolated and purified human polyhomeotic 2 polypeptide. The isolated and purified; human polyhomeotic 2 polypeptide consists of at least 14 contiguous amino acids selected from the amino acid sequence shown in SEQ ID NO:2.
Yet another embodiment of the invention provides a human polyhomeotic 2 fusion protein. The human polyhomeotic 2 fusion protein comprises a first protein segment and a second protein segment fused together by means of a peptide bond. The first protein segment consists of at least 14 contiguous amino acids of a human polyhomeotic 2 protein.
Still another embodiment of the invention provides a preparation of antibodies which specifically bind to a human polyhomeotic 2 protein.
Even another embodiment of the invention provides an isolated and purified subgenomic polynucleotide. The isolated and purified subgenomic polynucleotide consists of at least 11 contiguous nucleotides selected from the nucleotide sequence shown in SEQ ID NO:1.
Yet another embodiment of the invention provides an expression construct for expressing all or a portion of a human polyhomeotic 2 protein. The expression construct comprises a promoter and a polynucleotide segment. The polynucleotide segment encodes at least 14 contiguous amino acids of a human polyhomeotic 2 protein. The polynucleotide segment is located downstream from the promoter. Transcription of the polynucleotide segment initiates at the promoter.
A further embodiment of the invention provides a homologously recombinant cell. The homologously recombinant cell comprises an incorporated new transcription unit wherein the new transcription unit comprises an, exogenous regulatory sequence, an exogenous exon, and a splice donor site. The transcription unit is located upstream of a coding sequence of an hph2 gene. The exogenous regulatory sequence directs transcription of the coding sequence of the hph2 gene. The new transcription unit is incorporated into the genome using segments of homologous DNA from the hph2 gene.
Still another embodiment of the invention provides a method of identifying neoplastic tissue of a human. The method comprises comparing the expression of a polyhomeotic 2 gene in a first tissue of a human suspected of being neoplastic with the expression of a polyhomeotic 2 gene in a second tissue of the human which is normal. Overexpression of the human polyhomeotic 2 gene in the first tissue identifies the first tissue as being neoplastic.
Even another embodiment of the invention provides a method to aid in the diagnosis or prognosis of neoplasia in a human. The method comprises comparing a polyhomeotic 2 gene, mRNA, or protein in a first tissue of a human suspected of being neoplastic with a polyhomeotic 2 gene, mRNA, or protein in a second tissue of a human which is normal. A difference between the polyhomeotic 2 genes, mRNAs, or proteins in the first and second tissues indicates neoplasia in the first tissue.
Another embodiment of the invention provides a method to aid in detecting a genetic predisposition to neoplasia in a human. The method comprises comparing a polyhomeotic 2 gene, mRNA, or protein in a fetal tissue of a human with a wild type human polyhomeotic 2 gene, mRNA, or protein. A difference between the polyhomeotic 2 gene, mRNA, or protein in the fetal tissue of the human and the wild-type human polyhomeotic 2 gene, mRNA, or protein indicates a genetic predisposition to neoplasia in the human.
Yet another embodiment of the invention provides method of identifing a human chromosome 1. The method comprises the steps of contacting a preparation of metaphase human chromosomes with a nucleotide probe comprising at least 12 contiguous nucleotides selected from the nucleotide sequence shown in SEQ ID NO:1 and detecting a region of a chromosome which specifically hybridizes to the nucleotide probe. A region of a chromosome which specifically hybridizes to the nucleotide probe is identified as a region of human chromosome 1.
Even another embodiment of the invention provides a therapeutic composition for treating neoplasia. The therapeutic- composition comprises a therapeutically effective amount of an antisense hph2 poynucleotide and a pharmaceutically acceptable carrier.
Yet another embodiment of the invention provides a therapeutic composition for treating neoplasia. The therapeutic composition comprises a therapeutically effective amount of an antibody which specifically binds to a human polyhomeotic 2 protein and a pharmaceutically acceptable carrier.
Still another embodiment of the invention provides a method of treating neoplasia. The method comprises the step of administering to a human a therapeutic hph2 composition.
A further embodiment of the invention provides a method of inducing a cell to change its pattern of differentiation. The method comprises the step of contacting a cell with an effective amount of a composition comprising all or a portion of a human polyhomeotic 2 gene or expression product. Said all or a portion of the human polyhomeotic 2 gene or expression product is capable of inducing the cell to change its pattern of differentiation.
The present invention thus provides the art with a novel human tumor suppressor gene called polyhomeotic 2 (hph2). The hph2 gene and protein can be used, inter alia, as therapeutic, prognostic, and diagnostic tools for proliferative and developmental disorders and to identify a p34.3 region of a human chromosome