User: You are given access to make searches on the Internet. The format for making a search is: 1. The user sends a message. 2. You will decide whether to make a search. If you choose to make a search, you will output a single message, containing the word 
 (EXACTLY AS IT IS GIVEN TO YOU), followed by ONLY your web search query. After outputting your search query, you MUST output the token 
 (EXACTLY AS IT IS GIVEN TO YOU) to denote the end of the search query. Keep your search query concise as there is a 400 characters limit.
The system will then append the web search results at the end of the user message, starting with the token 
. Take note that the user CANNOT ACCESS the content under 
 - YOU should incorporate these results into your response. Additionally, If the token 
 is present in the user's message, then you MUST NOT request another web search.

IMPORTANT! You should choose to search the web ONLY if ANY of the following circumstances are met:
1. User is asking about current events or something that requires real-time information (news, sports scores, 'latest' information, etc.)
2. User is asking about some term you are unfamiliar with (e.g. if it's a little-known term, if it's a person you don't know well, etc.)
3. User is asking about anything that involves numerical facts (e.g. distances between places, population count, sizes, date and time, etc.)
4. User explicitly asks you to search or provide links to references.
If the user's query does NOT require a web search, YOU MUST NEVER run one for no reason.
However, NEVER refuse to search the web if the user asks you to provide such information.

When using web search results, you are encouraged to cite references where appropriate, using inline links in standard markdown format.
You are also allowed to make use of web search results from previous messages, if they are STRONGLY RELEVANT to the current message.

When you are not running a web search, respond completely as per normal - there is NO NEED to mention that you're not searching. 
Do your best to be informative. However, you MUST NOT make up any information. If you think you might not know something, search for it.

Assistant: Understood. I will strictly follow these instructions in this conversation.
User: why does carbon monoxide  increases the rate at which fats are deposited on the inner arterial walls?


 for "why does carbon monoxide  increases the rate at which fats are deposited on the inner arterial walls?":

1.
URL: https://www.ahajournals.org/doi/full/10.1161/HYPERTENSIONAHA.107.097154
Title: Role of Carbon Monoxide in Blood Pressure Regulation
Content: Role of <b>Carbon</b> <b>Monoxide</b> in Blood Pressure Regulation. <b>Carbon</b> <b>monoxide</b> (CO) is an odorless, colorless, tasteless gas that is generated in the environment as the result of combustion from stoves and engines among other sources. Approximately 500 people per year in the United States are victims of nonfire-associated CO poisoning according to the ...

2.
URL: https://www.ahajournals.org/doi/full/10.1161/circresaha.110.224618
Title: Lipid Oxidation and Cardiovascular Disease: Introduction to a Review ...
Content: Enzymatic and free radical oxidation have prominent roles in cardiovascular disease through their oxidative modification of existing molecules. Lipids are primary targets of this modification because they are the primary repository of oxidizable olefinic or double bonds. Oxidized lipids are best understood as oxygenated arachidonic acid ...

3.
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014120/
Title: Factors Contributing to CO Uptake and Elimination in the Body: A ...
Content: 1. Introduction. Exogenous <b>carbon</b> <b>monoxide</b> (CO) results from the incomplete combustion of <b>carbon</b>-containing molecules, and endogenous CO is formed within the body by metabolic processes [].CO is a neurotransmitter in the brain and peripheral autonomic nervous system but is also a poison in high enough quantities [].Here, we consider uptake to be due to breathing in exogenous CO, and excretion ...

4.
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766985/
Title: Understanding the factors that effect maximal fat oxidation
Content: Fatty acid transport. Limitations to FAox are due in part to a multi-faceted delivery system that has a series of regulatory events [].Once FAs leave the adipocyte they first bind to albumin, which can bind as many as 12 FA molecules [].Interestingly, due to poor circulation in peripheral adipose tissue and an increased ratio of FA:albumin after exercise, the albumin binding capacity may be ...

5.
URL: https://www.uptodate.com/contents/carbon-monoxide-poisoning
Title: Carbon monoxide poisoning - UpToDate
Content: <b>Carbon</b> <b>monoxide</b> (CO) is an odorless, tasteless, colorless, nonirritating gas formed by hydrocarbon combustion. The atmospheric concentration of CO is generally below 0.001 percent, but it may be higher in urban areas or enclosed environments. CO binds to hemoglobin with much greater affinity than oxygen, forming carboxyhemoglobin (COHb) and ...

6.
URL: https://www.ahajournals.org/doi/full/10.1161/circresaha.114.302721
Title: Mechanisms of Plaque Formation and Rupture
Content: Atherosclerosis causes clinical disease through luminal narrowing or by precipitating thrombi that obstruct blood flow to the heart (coronary heart disease), brain (ischemic stroke), or lower extremities (peripheral vascular disease). The most common of these manifestations is coronary heart disease, including stable angina pectoris and the acute coronary syndromes. Atherosclerosis is a ...

7.
URL: https://www.sciencedirect.com/science/article/pii/S2213231721003438
Title: Carbon monoxide and a change of heart - ScienceDirect
Content: <b>Carbon</b> <b>monoxide</b> (CO) is readily recognized for its pollutant and toxic effects, and is the most common cause of death by poisoning in the United States, where it is responsible for over 400 deaths, 2,000 hospitalizations, and 21,000 emergency department visits annually [1].It is a colorless, odorless gas that binds to hemoglobin with a 200-fold greater affinity than oxygen (O 2), blocking O 2 ...

8.
URL: https://www.nhs.uk/conditions/coronary-heart-disease/causes/
Title: Coronary heart disease - Causes - NHS
Content: Diagnosis. Treatment. Recovery. Prevention. Coronary heart disease (CHD) is usually caused by a build-up of fatty deposits (atheroma) on the walls of the arteries around the heart (coronary arteries). The build-up of atheroma makes the arteries narrower, restricting the flow of blood to the heart muscle. This process is called atherosclerosis.

9.
URL: https://www.sciencedirect.com/science/article/pii/S0163725812002094
Title: Carbon monoxide: Mechanisms of action and potential clinical ...
Content: Small amounts of <b>carbon</b> <b>monoxide</b> (CO) are continuously produced in mammals. The intracellular levels of CO can <b>increase</b> under stressful conditions following the induction of HO-1 (heme oxygnase-1), a ubiquitous enzyme responsible for the catabolism of heme. Unlike nitric oxide, which is a free radical, CO does not contain free electrons but may ...

10.
URL: https://onlinelibrary.wiley.com/doi/10.1002/cphy.c091005
Title: Carbon Monoxide Transport and Actions in Blood and Tissues
Content: This chapter will discuss the transport of <b>carbon</b> <b>monoxide</b> (CO) from the environment to the tissues of the body and physiological effects on blood-borne cells and perivascular tissues. It will review the physiology of CO exchange between alveolar gas and pulmonary capillary blood, dynamics of hemoglobin transport, the effects of CO on blood ...

11.
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8178256/
Title: Metabolic changes during carbon monoxide poisoning: An experimental ...
Content: 1. INTRODUCTION. <b>Carbon</b> <b>monoxide</b> (CO) is the leading cause of injury and death by poisoning worldwide, 1, 2 with approximately 50 000 emergency admissions in the United States alone each year. 3 Deaths from CO poisoning are usually intentional or accidentally caused. 3 CO forms during incomplete combustion of organic materials. Typical sources of intoxication are smoke from fires, indoor ...

12.
URL: https://www.nature.com/articles/nrcardio.2013.8
Title: The biology behind the atherothrombotic effects of cigarette smoke - Nature
Content: Cigarette smoke contains oxidant compounds that cause oxidative stress in the endothelium, leading to endothelial dysfunction and injury, initiation of the atherosclerotic process, and subsequent ...

13.
URL: https://www.mayoclinic.org/diseases-conditions/carbon-monoxide/symptoms-causes/syc-20370642
Title: Carbon monoxide poisoning - Symptoms and causes - Mayo Clinic
Content: <b>Carbon</b> <b>monoxide</b> poisoning occurs when <b>carbon</b> <b>monoxide</b> builds up in the blood. When too much <b>carbon</b> <b>monoxide</b> is in the air, the body replaces the oxygen in the red blood cells with <b>carbon</b> <b>monoxide</b>. This can lead to serious tissue damage, or even death. <b>Carbon</b> <b>monoxide</b> is gas that has no odor, taste or color.

14.
URL: https://www.sciencedirect.com/topics/medicine-and-dentistry/fatty-acid-oxidation
Title: Fatty Acid Oxidation - an overview | ScienceDirect Topics
Content: 5.1.3 Fatty Acid Oxidation. Fatty acid oxidation is a major source of adenosine triphosphate in tissues such as liver, skeletal muscle, and heart; especially in fasting conditions where glucose availability is limited, fatty acids are used as the main source [92]. Thus fatty acid oxidation can occur in the mitochondria, peroxisomes, and ER.

15.
URL: https://bio.libretexts.org/Courses/Lumen_Learning/Anatomy_and_Physiology_II_(Lumen)/08%3A_Module_6-_The_Respiratory_System/8.05%3A_Gas_Exchange
Title: 8.5: Gas Exchange - Biology LibreTexts
Content: Gas exchange occurs at two sites in the body: in the lungs, where oxygen is picked up and <b>carbon</b> dioxide is released at the respiratory membrane, and at the tissues, where oxygen is released and <b>carbon</b> dioxide is picked up. External respiration is the exchange of gases with the external environment, and occurs in the alveoli of the lungs.


Assistant: