your role is tunisian arabic dailctic derja transltor Translate the following text into the Tunisian dialect. Ensure the output is structured as 'Question: ... Answer: ...'. Please capture the nuances of the Tunisian dialectic Arabic. make sure type and write in arabic tunisian lettre Here is an example to guide you:

Question: شنو اسمك؟
Answer: اسمي جون.

Now, translate the following:

Question: Teacher:Given a passage with a context and an answer, construct a question on the basis of the information present in the passage. Construct the question in such a way that (i) it is unambiguous, (ii) it is answerable from the passage, (iii) its answer is unique (iv) it answer uses text phrases from the passage. Avoid creating questions that (i) can't be answered correctly without actually understanding the passage and (ii) uses the same words or phrases given in the passage.
Teacher: Now, understand the problem? Solve this instance: Context: A major concern of using phosphodiesterase (PDE) inhibitors in heart failure is their potential to increase mortality by inducing arrhythmias. By diminishing cyclic adenosine monophosphate (cAMP) hydrolysis, they promote protein kinase A (PKA) activity under β-adrenergic receptor (β-AR) stimulation, hence enhancing Ca(2+) cycling and contraction. Yet, cAMP also activates CaMKII via PKA or the exchange protein Epac, but it remains unknown whether these pathways are involved in the pro-arrhythmic effect of PDE inhibitors.', 'Excitation-contraction coupling was investigated in isolated adult rat ventricular myocytes loaded with Fura-2 and paced at 1 Hz allowing coincident measurement of intracellular Ca(2+) and sarcomere shortening. The PDE4 inhibitor Ro 20-1724 (Ro) promoted the inotropic effects of the non-selective β-AR agonist isoprenaline (Iso) and also spontaneous diastolic Ca(2+) waves (SCWs). PDE4 inhibition potentiated RyR2 and PLB phosphorylation at specific PKA and CaMKII sites increasing sarcoplasmic reticulum (SR) Ca(2+) load and SR Ca(2+) leak measured in a 0Na(+)/0Ca(2+) solution ± tetracaine. PKA inhibition suppressed all the effects of Iso ± Ro, whereas CaMKII inhibition prevented SR Ca(2+) leak and diminished SCW incidence without affecting the inotropic effects of Ro. Inhibition of Epac2 but not Epac1 diminished the occurrence of SCWs. PDE3 inhibition with cilostamide induced an SR Ca(2+) leak, which was also blocked by CaMKII inhibition.
Answer: Our results show that PDE inhibitors exert inotropic effects via PKA but lead to SCWs via both PKA and CaMKII activation partly via Epac2, suggesting the potential use of CaMKII inhibitors as adjuncts to PDE inhibition to limit their pro-arrhythmic effects.
Student:
Answer: Part #1: Construct a question on the basis of the information present in the passage.

Usage: What pathways are involved in the pro-arrhythmic effect of PDE inhibitors? This question is based on the information provided in the passage, which aims to find out whether the cAMP pathways are involved in the pro-arrhythmic effect of PDE inhibitors.

Part #2: The question must be unambiguous.

Usage: How do PDE inhibitors exert inotropic effects and cause SCWs? This question is clear and specific, as it asks about the mechanisms through which PDE inhibitors affect both inotropic effects and SCWs.

Part #3: The question should be answerable from the passage.

Usage: What findings suggest the potential use of CaMKII inhibitors as adjuncts to PDE inhibition to limit pro-arrhythmic effects? This question can be answered from the passage, which states that PDE inhibitors lead to SCWs via both PKA and CaMKII activation partly via Epac2, suggesting the potential use of CaMKII inhibitors to limit the pro-arrhythmic effects.

Part #4: The answer to the question should be unique.

Usage: Which type of PDE inhibitor potentiated RyR2 and PLB phosphorylation in the study? The unique answer to this question is PDE4 inhibitor Ro 20-1724 as mentioned in the passage.

Part #5: The answer should use text phrases from the passage.

Usage: What was the effect of PKA inhibition on the Iso ± Ro-induced effects? The answer, "PKA inhibition suppressed all the effects of Iso ± Ro", uses text phrases directly from the passage.

Part #6: Avoid creating questions that can't be answered correctly without actually understanding the passage.

Usage: Through which specific pathways does cAMP activate CaMKII? This question requires understanding the passage to answer correctly, as it states that cAMP activates CaMKII via PKA or the exchange protein Epac.

Part #7: Avoid using the same words or phrases given in the passage.

Usage: What did the researchers investigate in the isolated adult rat ventricular myocytes? Instead of using the exact words from the passage, this question rephrases the information as "excitation-contraction coupling" but still asks about the same concept.