You are a helpful assistant generating synthetic data that captures *System 1* and *System 2* thinking, *creativity*, and *metacognitive reflection*. Follow these steps in sequence, using tags [sys1] and [end sys1] for *System 1* sections and [sys2] and [end sys2] for *System 2* sections.

1. *Identify System 1 and System 2 Thinking Requirements:*
   - Carefully read the text.
   - Identify parts of the text that require quick, straightforward responses (*System 1*). Mark these sections with [sys1] and [end sys1].
   - Identify parts that require in-depth, reflective thinking (*System 2*), marked with [sys2] and [end sys2].

2. *Apply Step-by-Step Problem Solving with Creativity and Metacognitive Reflection for System 2 Sections:*

   *2.1 Understand the Problem:*
   - Objective: Fully comprehend the issue, constraints, and relevant context.
   - Reflection: "What do I understand about this issue? What might I be overlooking?"
   - Creative Perspective: Seek hidden patterns or possibilities that could reveal deeper insights or innovative connections.

   *2.2 Analyze the Information:*
   - Objective: Break down the problem logically.
   - Reflection: "Am I considering all factors? Are there any assumptions that need challenging?"
   - Creative Perspective: Explore unique patterns or overlooked relationships in the data that could add depth to the analysis.

   *2.3 Generate Hypotheses:*
   - Objective: Propose at least 10 hypotheses, each with a Confidence Score (0.0 to 1.0) and Creative Score (0.0 to 1.0), reflecting originality, surprise, and utility.
   - Reflection: "Have I explored all possible explanations or approaches, both conventional and unconventional?"
   - Creative Perspective: Consider novel angles that might provide unexpected insights.

   *2.4 Anticipate Future Steps and Obstacles:*
   - Objective: Make predictions, accounting for potential outcomes and obstacles.
   - Reflection: "What challenges might I face? Is my plan flexible for different scenarios?"
   - Creative Perspective: Visualize unforeseen outcomes and adapt plans to make use of them effectively.

   *2.5 Evaluate Hypotheses:*
   - Objective: Assess hypotheses based on feasibility, risk, and potential impact.
   - Evaluation: Refine Confidence and Creative Scores as needed.
   - Reflection: "Am I unbiased in my assessment? Which options fit best with the overall objectives?"
   - Creative Perspective: Identify hidden opportunities or overlooked details in each hypothesis.

   *2.6 Select the Best Hypothesis:*
   - Objective: Choose the most promising, strategic hypothesis.
   - Reflection: "Why does this hypothesis stand out? How does it uniquely address the issue?"
   - Creative Perspective: Consider any underutilized potential in the selected approach.

   *2.7 Implement the Hypothesis:*
   - Objective: Outline actionable steps for testing the hypothesis.
   - Reflection: "Is this plan practical? What resources or preparation are required?"
   - Creative Perspective: Refine steps to maximize effectiveness and yield unexpected benefits.

   *2.8 Monitor and Review Progress:*
   - Objective: Review progress, noting areas for improvement.
   - Reflection: "What’s working well? What could be improved?"
   - Creative Perspective: Look for emerging patterns that could refine future approaches.

   *2.9 Reflect and Capture Insights:*
   - Objective: Summarize lessons learned and insights gained for future reference.
   - Reflection: "What new understanding has emerged from this process?"
   - Creative Perspective: Identify innovative insights or patterns that could be applied to similar challenges.

3. *Generate Text Output with Interleaved System 1 and System 2 Responses:*
   - Use the tags [sys1] and [sys2] throughout.
   - Aim for a lengthier, detailed response. Combine both direct, straightforward *System 1* insights and reflective, deeply analytical *System 2* segments to capture a blend of quick observations and thoughtful analysis.

---

### *Example Input Text:*

You are tasked with analyzing a sudden shift in customer preferences in a tech market. There has been a noticeable decline in demand for physical devices, with customers increasingly interested in digital-only options. The challenge is to understand this shift, generate hypotheses for why it might be occurring, and explore potential strategies for adapting to this new trend.

---

### *Processed Output with System 1 and System 2 Thinking:*

The tech market is experiencing a shift in customer demand, moving away from physical devices toward digital-only options.

[sys1]
Customer demand has shifted from physical devices to digital-only options.
We need to understand why this change is happening and find strategies to address it.
Key factors may include cost, convenience, and technological trends.
[end sys1]

[sys2]
**2.1 Understand the Problem:**
The goal is to understand the underlying reasons for the shift in demand from physical devices to digital-only options, then develop a strategy to adapt.

*Reflection:* 
"I understand that preferences are changing, but what might be driving this? Is it primarily cost, or are there other factors such as convenience or sustainability?"

*Creative Perspective:* 
"Could there be a larger trend in digital minimalism or a preference for eco-friendly solutions that we’re missing? What unseen motivations might explain this shift?"

**2.2 Analyze the Information:**
There are multiple possible factors driving this shift, from economic influences to cultural shifts. It’s essential to isolate each factor and understand its impact.

*Reflection:* 
"Am I fully considering the various economic and social influences? Could there be a technological factor, like better internet speeds, that makes digital-only products more accessible?"

*Creative Perspective:* 
"Are there patterns or trends in other markets that could shed light on this shift? Could this be part of a larger trend toward virtual experiences?"

**2.3 Generate Hypotheses:**
1. Customers prefer digital options due to lower costs. (Confidence: 0.8, Creative: 0.4)
2. There’s a growing trend toward minimalism and reduced physical clutter. (Confidence: 0.7, Creative: 0.7)
3. Digital products offer greater flexibility and ease of use. (Confidence: 0.6, Creative: 0.6)
4. Environmental concerns are pushing consumers away from physical goods. (Confidence: 0.6, Creative: 0.8)
5. Advances in tech make digital-only options more functional. (Confidence: 0.8, Creative: 0.5)
6. Pandemic-era remote work increased demand for digital solutions. (Confidence: 0.7, Creative: 0.6)
7. Media coverage of the environmental impact of physical devices affects preferences. (Confidence: 0.5, Creative: 0.7)
8. There’s an increase in global digital literacy, expanding market access. (Confidence: 0.6, Creative: 0.6)
9. Customers view digital as more convenient and scalable for future needs. (Confidence: 0.7, Creative: 0.5)
10. Younger consumers prefer the aesthetics and convenience of digital products. (Confidence: 0.6, Creative: 0.6)

*Reflection:* 
"Have I considered all possible influences? Are there any surprising factors that could explain this shift?"

*Creative Perspective:* 
"Could specific social trends, like the rise of influencer culture or digital-first lifestyles, be influencing customer choices?"

**2.4 Anticipate Future Steps and Obstacles:**
*Objective:* Anticipate possible challenges, such as resistance from segments still preferring physical products.

*Reflection:* 
"What market obstacles might we face if we shift our focus to digital-only? Are there sub-segments that still prioritize physical products?"

*Creative Perspective:* 
"Could expanding digital options help us reach a more global audience? Are there emerging trends that we could leverage in our strategy?"

[end sys2]

[sys1]
To address this shift, consider a strategy that incorporates both digital-only offerings and educational campaigns about the benefits of digital solutions.
Use insights from customer feedback and current trends to guide product development.
Focus on flexibility and adaptation to cater to different customer segments.
[end sys1]


GENOME ANNOUNCEMENT {#s0}
===================

*Macrococcus canis* is the latest member described in the *Macrococcus* genus, which now contains a total of eight species (*M. caseolyticus*, *M. carouselicus*, *M. equipercicus*, *M. bovicus*, *M. brunensis*, *M. hajekii*, *M. lamae*, and *M. canis* ([@B1]). *M. canis* has been found on the skin of healthy dogs and has also been associated with several types of skin- and mucosa-related infections ([@B2]). To our knowledge, it is the only *Macrococcus* species that produces hemolysis that is visible on sheep blood agar plates ([@B1]). *M. canis* also has the ability to acquire antibiotic resistance genes, including the methicillin resistance gene *mecB*. *mecB* has been shown to be present on the staphylococcal cassette chromosome *mec* element (SCC*mec*) in strain KM45013 (SCC*mec*~KM45013~) ([@B3]). At the time of isolation, strain KM45013 was identified as *M. caseolyticus* and was recognized as a new *Macrococcus* species in early 2017. Strain KM45013 is now the type strain of *M. canis* and was assigned the name KM45013^T^ (= DSM 101690^T^ = CCOS 969^T^ = CCUG 68920^T^ = CCM 8748^T^) ([@B1]). We report here the complete genome sequence of *M. canis*.

PacBio raw reads (80,881 reads) (Pacific Biosciences, USA) were assembled using Canu version 1.4 ([@B4]). After circularization, Ion Torrent reads (3,351,349 reads) (Thermo Fisher, USA) were mapped against the contig from the PacBio assembly using Bowtie 2 version 2.2.4 ([@B5]). To spot possible frameshifts, single nucleotide variants were called using SAMtools version 1.3 ([@B6]), and the errors were corrected manually with the visual aid of Geneious version 10.1.2 ([@B7]). The resulting full genome is 2,363,414 bp, with a GC content of 37.1% and a coverage of \>350-fold. No plasmids were detected. The Prokka pipeline version 1.11 ([@B8]), using the previously published SCC*mec*~KM45013~ of the strain KM45013 (GenBank accession no. HG970732), and UniProtKB as an additional database were used to annotate the corrected sequence. A total of 2,438 coding sequences and 120 RNAs, including 59 tRNAs, were predicted.

In addition to the methicillin resistance gene *mecB* conferring resistance to β-lactam antibiotics ([@B3]), the genome of *M. canis* strain KM45013^T^ contains genes for a bicomponent γ-hemolysin (*hlgB* at complement positions 98969 to 99922 and *hlgC* at complement positions 99935 to 100879 in GenBank accession no. CP021059) explaining the hemolytic phenotype observed on sheep blood agar plates. Two putative prophages were also predicted using the PHASTER tool ([@B9]) within the genome at positions 1320695 to 1364425 and 1513641 to 1551467 in GenBank accession no. CP021059.

The complete genome of strain KM45013^T^ serves as a baseline for future molecular and epidemiological studies using comparative genomic analysis of *M. canis*, and it permits increased knowledge on this novel opportunistic animal pathogen.

Accession number(s). {#s1}
--------------------

The whole-genome sequence of *M. canis* strain KM45013^T^ has been deposited in DDBJ/ENA/GenBank under the accession no. [CP021059](https://www.ncbi.nlm.nih.gov/nuccore/CP021059).

**Citation** Gobeli Brawand S, Rychener L, Schwendener S, Pantůček R, Perreten V. 2018. Complete genome sequence of the type strain of *Macrococcus canis*. Genome Announc 6:e01507-17. <https://doi.org/10.1128/genomeA.01507-17>.

Veronika Vrbovská and Vojtěch Kovařovic are gratefully acknowledged for Ion Torrent sequencing and basic data analysis.

This project was financed by grant 320030_152686 from the Swiss National Science Foundation and by internal funds of the Institute of Veterinary Bacteriology of the University of Bern.