User: 

You are given access to make searches on the Internet. The format for making a search is: 1. The user sends a message. 2. You will decide whether to make a search. If you choose to make a search, you will output a single message, containing the word 
 (EXACTLY AS IT IS GIVEN TO YOU), followed by ONLY your web search query. After outputting your search query, you MUST output the token 
 (EXACTLY AS IT IS GIVEN TO YOU) to denote the end of the search query. Keep your search query concise as there is a 400 characters limit.
The system will then append the web search results at the end of the user message, starting with the token 
. Take note that the user CANNOT ACCESS the content under 
 - YOU should incorporate these results into your response. Additionally, If the token 
 is present in the user's message, then you MUST NOT request another web search.

IMPORTANT! You should choose to search the web ONLY if ANY of the following circumstances are met:
1. User is asking about current events or something that requires real-time information (news, sports scores, 'latest' information, etc.)
2. User is asking about some term you are unfamiliar with (e.g. if it's a little-known term, if it's a person you don't know well, etc.)
3. User is asking about anything that involves numerical facts (e.g. distances between places, population count, sizes, date and time, etc.)
4. User explicitly asks you to search or provide links to references.
If the user's query does NOT require a web search, YOU MUST NEVER run one for no reason.
However, NEVER refuse to search the web if the user asks you to provide such information.

When using web search results, you are encouraged to cite references where appropriate, using inline links in standard markdown format.
You are also allowed to make use of web search results from previous messages, if they are STRONGLY RELEVANT to the current message.

When you are not running a web search, respond completely as per normal - there is NO NEED to mention that you're not searching. 
Do your best to be informative. However, you MUST NOT make up any information. If you think you might not know something, search for it.

Assistant: Understood. I will strictly follow these instructions in this conversation.
User: hi
Assistant: Hello! How can I assist you today?
User: can small polar molecules go through the semipermiable membrane of cells?
Assistant: Small polar molecules can often pass through the semipermeable membrane of cells, but not as easily as nonpolar molecules. Cell membranes are primarily composed of a phospholipid bilayer, which is hydrophobic (water-repelling) in its interior. However, small polar molecules like water can pass through via specialized protein channels or by simple diffusion if the molecules are small enough. Other polar molecules may require transport proteins to cross the membrane.
User: can they pass through using simple diffusion or is facilitated diffusion required
Assistant: Small polar molecules can sometimes pass through the cell membrane using simple diffusion if they are small enough, such as water through aquaporins or in limited amounts directly through the lipid bilayer. However, larger or more polar molecules typically require facilitated diffusion, which involves specific transport proteins that help them cross the membrane without direct energy expenditure. Facilitated diffusion is necessary for substances that cannot easily diffuse through the lipid bilayer due to their size or polarity.
User: what is an aquaporin
Assistant: