Title: Meta-analysis on Risk Factors for Childhood Tuberculous Meningitis Mortality

1. Selection of Topic and Study Design:
- The aim of this meta-analysis is to identify the risk factors associated with mortality in children with tuberculous meningitis.
- The study design will involve conducting a systematic review and meta-analysis of published studies on the subject.

2. Retrieval and Collection of original literature:
- A comprehensive search will be conducted in electronic databases (such as PubMed, Embase, and Cochrane Library) to identify relevant studies.
- The search strategy will include appropriate medical subject headings (MeSH terms) and keywords related to childhood tuberculous meningitis mortality and risk factors.
- Additional sources, such as reference lists of retrieved articles and relevant reviews, will be scanned to identify any additional studies.

3. Inclusion of eligible studies based on selection criteria:
- Studies will be screened based on predetermined inclusion criteria, including:
- Studies reporting on risk factors associated with mortality in children with confirmed or suspected tuberculous meningitis.
- Studies with a defined study population of children (age range specified).
- Studies with clear outcome measures related to mortality.
- Observational studies (cohort, case-control, or cross-sectional design).
- Exclusion criteria may include studies with incomplete or insufficient data, duplicate publications, or studies without a control/comparison group.

4. Assessment of quality of included studies:
- The quality of included studies will be assessed using appropriate tools, such as the Newcastle-Ottawa Scale for non-randomized studies or the Cochrane Collaboration’s Risk of Bias tool for randomized controlled trials.
- Assessment will be performed independently by two reviewers, and any discrepancies will be resolved through discussion or consultation with a third reviewer.

5. Data extraction, completion of data extraction forms, and database establishment:
- Relevant data will be extracted from included studies, including study characteristics (author, year, country), participant characteristics (age, gender, sample size), risk factors assessed, and outcome measures.
- Data will be entered into a pre-designed data extraction form and stored in a database for analysis.

6. Data synthesis and analysis:
- Meta-analysis will be performed using appropriate statistical methods, such as random-effects models or fixed-effects models, depending on the heterogeneity of included studies.
- Subgroup analyses or sensitivity analyses will be conducted if applicable and deemed necessary.
- Forest plots and summary measures, such as odds ratios or risk ratios, will be used to present the pooled estimates with corresponding confidence intervals.

7. Summary and reporting:
- The results of the meta-analysis will be summarized and reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines.
- The conclusions regarding the identified risk factors for childhood tuberculous meningitis mortality will be discussed, highlighting the strength of evidence and implications for clinical practice.

翻译为中文（要求语句通顺，逻辑流畅）