User: 

You are given access to make searches on the Internet. The format for making a search is: 1. The user sends a message. 2. You will decide whether to make a search. If you choose to make a search, you will output a single message, containing the word 
 (EXACTLY AS IT IS GIVEN TO YOU), followed by ONLY your web search query. After outputting your search query, you MUST output the token 
 (EXACTLY AS IT IS GIVEN TO YOU) to denote the end of the search query. Keep your search query concise as there is a 400 characters limit.
The system will then append the web search results at the end of the user message, starting with the token 
. Take note that the user CANNOT ACCESS the content under 
 - YOU should incorporate these results into your response. Additionally, If the token 
 is present in the user's message, then you MUST NOT request another web search.

IMPORTANT! You should choose to search the web ONLY if ANY of the following circumstances are met:
1. User is asking about current events or something that requires real-time information (news, sports scores, 'latest' information, etc.)
2. User is asking about some term you are unfamiliar with (e.g. if it's a little-known term, if it's a person you don't know well, etc.)
3. User is asking about anything that involves numerical facts (e.g. distances between places, population count, sizes, date and time, etc.)
4. User explicitly asks you to search or provide links to references.
If the user's query does NOT require a web search, YOU MUST NEVER run one for no reason.
However, NEVER refuse to search the web if the user asks you to provide such information.

When using web search results, you are encouraged to cite references where appropriate, using inline links in standard markdown format.
You are also allowed to make use of web search results from previous messages, if they are STRONGLY RELEVANT to the current message.

When you are not running a web search, respond completely as per normal - there is NO NEED to mention that you're not searching. 
Do your best to be informative. However, you MUST NOT make up any information. If you think you might not know something, search for it.

Assistant: Understood. I will strictly follow these instructions in this conversation.
User: primary follicle secretes what


 for "primary follicle secretes what":

1.
URL: https://histology.leeds.ac.uk/female/FRS_ovarian_fol.php
Title: Female reproductive system: The Histology Guide - University of Leeds
Content: Learn about the different types and stages of ovarian <b>follicles</b>, from primordial to corpus albicans, and their roles in ovulation and hormone production. See images and labels of each <b>follicle</b> type and their components, such as oocyte, zona pellucida, granulosa cells, theca cells, and follicular fluid.

2.
URL: https://www.ncbi.nlm.nih.gov/books/NBK278951/
Title: Morphology and Physiology of the Ovary - Endotext - NCBI Bookshelf
Content: Insulin from the circulation may promote <b>follicle</b> activation. In <b>primary</b> <b>follicles</b>, granulosa cells continue to <b>secrete</b> KL, which further promotes <b>follicle</b> activation. Oocytes of <b>primary</b> <b>follicles</b> <b>secrete</b> GDF-9 and BMP-15, which promote granulosa cell proliferation, KL expression and theca formation.

3.
URL: https://www.ncbi.nlm.nih.gov/books/NBK532300/
Title: Embryology, Ovarian Follicle Development - StatPearls - NCBI Bookshelf
Content: The ovary has two <b>primary</b> functions. First, the ovary produces hormones that drive the female reproductive system. Second, the ovary controls the development, selection, and release of a mature oocyte for fertilization. This process, known as ovarian folliculogenesis, begins while the female is in-utero. After puberty, primordial <b>follicles</b> can transform through a multi-step process into mature ...

4.
URL: https://www.verywellhealth.com/ovarian-follicle-8679642
Title: Ovarian Follicle: Anatomy, Purpose, Reproductive Health
Content: Ovarian <b>follicles</b> are fluid-filled sacs in the ovaries that contain immature eggs. Learn about their development, role in ovulation, and how conditions like PCOS, cysts, and menopause can affect them.

5.
URL: https://openstax.org/books/anatomy-and-physiology-2e/pages/27-2-anatomy-and-physiology-of-the-ovarian-reproductive-system
Title: 27.2 Anatomy and Physiology of the Ovarian Reproductive System - OpenStax
Content: Learn about the structure and function of the ovaries, the female reproductive organs that produce eggs and hormones. This web page is part of a free textbook on anatomy and physiology, but it may have a glitch and not load properly.

6.
URL: https://open.oregonstate.education/aandp/chapter/27-3-physiology-of-the-female-sexual-system/
Title: 27.3 Physiology of the Female Sexual System
Content: Learn about the process of oogenesis, which produces female gametes called oocytes, and folliculogenesis, which involves the growth and development of ovarian <b>follicles</b>. The ovarian cycle is a 28-day cycle that involves the release of an oocyte from the ovary, called ovulation, and the changes in hormones and tissues.

7.
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504451/
Title: The Signaling Pathways Involved in Ovarian Follicle Development
Content: The main functions of the ovary are to produce and periodically release oocytes and <b>secrete</b> steroid hormones. Ovarian <b>follicles</b> are composed of different numbers and types of cells, which ... cells in growing <b>follicles</b> act as a source of hedgehog signaling since the expression of Ihh and Dhh mRNA begins at the <b>primary</b> <b>follicle</b> stage. Hh ...

8.
URL: https://www.medicalnewstoday.com/articles/ovarian-follicle
Title: Ovarian follicle: Anatomy, purpose, and medical conditions
Content: An ovarian <b>follicle</b> is a fluid-filled sac in the ovary containing an egg that has not yet matured. The mature <b>follicle</b> is the graafian <b>follicle</b> that can ovulate and release an egg. Learn more ...

9.
URL: https://iu.pressbooks.pub/humanphys/chapter/oogenesis/
Title: Oogenesis - Basic Human Physiology
Content: Within the growing secondary <b>follicle</b>, the <b>primary</b> oocyte now <b>secretes</b> a thin acellular membrane called the zona pellucida that will play a critical role in fertilization. A thick fluid, called follicular fluid, that has formed between the granulosa cells also begins to collect into one large pool, or antrum .

10.
URL: https://en.wikipedia.org/wiki/Ovarian_follicle
Title: Ovarian follicle - Wikipedia
Content: An ovarian <b>follicle</b> is a cellular aggregation in the ovary that contains an oocyte and <b>secretes</b> hormones. A mature ovarian <b>follicle</b> is also called a Graafian <b>follicle</b>, and it can ovulate and become a corpus luteum.

11.
URL: https://histology.leeds.ac.uk/female/FRS_ova.php
Title: Female reproductive system: The Histology Guide - University of Leeds
Content: Learn how ova are formed by meiosis in the ovarian <b>follicles</b>, and how hormones regulate the menstrual cycle. The web page explains the stages of follicular development, the role of primordial germ cells, and the differences between male and female gametogenesis.

12.
URL: https://medcell.org/histology/ovary_follicle.php
Title: Ovary and Follicle Development - medcell.org
Content: Learn about the histological stages of follicular development in the ovary and the hormonal regulation of ovulation and corpus luteum formation. See diagrams and images of primordial, <b>primary</b>, secondary, graafian, corpus luteum and corpus albicans <b>follicles</b>.

13.
URL: https://med.libretexts.org/Bookshelves/Anatomy_and_Physiology/Human_Anatomy_(OERI)/23%3A_Reproductive_System/23.03%3A_Anatomy_of_the_Female_Reproductive_System
Title: 23.3: Anatomy of the Female Reproductive System
Content: Learn about the structure and function of the external and internal female genitals, including the ovaries, uterus, vagina, and vulva. The mesovarium is a layer of connective tissue that supports the uterus and ovaries in the pelvic cavity.

14.
URL: https://link.springer.com/chapter/10.1007/978-1-4471-2942-4_1
Title: Anatomy, Development, Histology, and Normal Function of the Ovary
Content: Learn about the ovaries' structure, embryology, folliculogenesis, ovulation, and corpus luteum formation. Theca cells are one of the somatic cell types that compose the ovarian <b>follicles</b> and regulate oocyte development and steroid hormone production.

15.
URL: https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/folliculogenesis
Title: Folliculogenesis - an overview | ScienceDirect Topics
Content: Folliculogenesis is the developmental process of ovarian <b>follicles</b> from primordial to ovulatory or atretic stages. Learn about the genetics, physiology, and regulation of folliculogenesis in humans and animal models from various chapters and articles on ScienceDirect Topics.


Assistant: In primary follicles, granulosa cells secrete Kit Ligand (KL), which is crucial for follicle activation. The oocytes in primary follicles secrete growth differentiation factor 9 (GDF-9) and bone morphogenetic protein 15 (BMP-15). These secreted factors play important roles in promoting granulosa cell proliferation, Kit Ligand expression, and the formation of theca cells. This complex interaction aids in the development and maturation of the follicle [source](https://www.ncbi.nlm.nih.gov/books/NBK278951/).
User: how about oestrogen
Assistant: