please spellcheck this subtitle, keep the time codes unchanged:

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Okay, so are you ready to dive deep today?
Because we are going to be like stepping

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into the world of oral medicine,
but with a COVID-19 twist.

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Oh, wow. So we're talking about, you
know, could ancient remedies actually

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have an impact
on a modern pandemic? Right.

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And we've got this fascinating
scientific review article.

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Yeah. And let me tell you,
I learned a lot prepping for this one.

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I bet you did. It's a very
in-depth article. Yeah.

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Well, and what's so
fascinating about this

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whole topic is we're
not just talking about

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folk remedies here.
We're seeing serious scientific

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inquiry into how these herbs work,
like on a molecular level,

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especially when it comes to COVID.
It really is incredible.

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It's like we've got this
treasure chest of,

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you know, this ancient
knowledge. And we're finally

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starting to understand
the science behind it.

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Specifically, this deep
dive focuses on how some

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herbs might help prevent
or even treat COVID-19.

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Exactly. And to understand
the significance,

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we need to acknowledge the
global impact of the pandemic.

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Yeah. I mean, while vaccines
have been a game changer,

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you know, they haven't been a

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perfect solution for everyone.
Right. Access is still an

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issue in many
parts of the world.

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And some people experience, you know,
less effective protection than others.

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Right. This is where exploring

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complementary approaches
like these herbal remedies

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becomes really intriguing.
It's like looking for

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extra tools in the toolkit, especially
ones that might be hiding in plain sight.

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Exactly. Now, traditional
medicine, particularly in

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Asia and Africa has relied
on herbs for centuries.

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And while the West often viewed this as,
you know, quote unquote,

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folk medicine, the scientific community
is now taking a closer look at these

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practices through a
more rigorous lens.

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It reminds me that saying
science is just magic

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that we haven't figured
out yet. I love that.

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And it's especially relevant here. Take
traditional Chinese medicine or TCM,

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for instance. It has this long documented
history of managing epidemics. Yeah.

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Think back to the 2003 SARS outbreak,

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also caused by a coronavirus.
TCM was used quite

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successfully then. So when
COVID-19 emerged,

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it was almost like they had a head start.
You mentioned some specific herbs

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used for COVID-19, and the research one
that stood out was scutillaria bicolensis,

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which I looked up. It's more commonly

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known as bakele skullcap, or
just bakele in with a deal with that.

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That's a great example.

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And it gets the heart of why
this research is so compelling. Okay.

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Bakele, and it turns
out, can actually

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interfere with the
virus's ability to replicate.

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The research highlighted how it binds to
specific proteins the virus needs,

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essentially putting a wrench
in its machinery.

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Wow. So it's not just
soothing symptoms.

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It's getting down to a
molecular level. Exactly.

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What about the citrus grandus
mentioned in the study?

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That's just tangerine peel,
right? That's right. Tangerine peel.

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And while we might think of it

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as a simple food, in TCM,
it's considered a potent medicinal.

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There's early research suggesting
that compounds in tangerine peel

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might have antiviral properties,
although more

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studies are needed to confirm
this specifically for COVID-19.

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Okay. That's really interesting.

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So tangerine peel is on my radar now,
but in the name of science, of course,

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what about that shabi jing
injection also mentioned?

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That sounds a little more intense.

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The shabi jing injection
is a great example

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of how TCM often
combines different herbs for

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a synergistic effect. It's not
just one magic bullet,

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but rather a carefully crafted formula.

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This particular injection was studied in
the context of COVID-19,

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and some preliminary findings suggest it
might help reduce the risk of pneumonia,

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a serious complication of the virus. Yeah,
it's really interesting to see these

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traditional practices being studied in
such a modern context.

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Yeah. But TCM isn't the only
traditional system showing promise.

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Ayurveda, the ancient Indian system
of medicine, also has a lot to offer.

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That's right. The research also
delved into Ayurveda and some of its,

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you know,
key players in the fight against COVID.

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What stood out to me was this herb

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Tino spra cordophilia,
also known as guduchi. Right.

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It's used in a traditional remedy called

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guduchi ganvati, which
just sounds pretty potent.

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Yeah, guduchi is
fascinating. Yeah.

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In Ayurveda,
it's considered a powerful adaptogen,

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meaning it helps the body
adapt to stress. And

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when we're talking about viral infections,
that's a really valuable property. Right.

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There's growing scientific
evidence to suggest

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that guduchi might
have antiviral properties,

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and researchers are
investigating its potential

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specifically against the
virus that causes COVID-19.

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Okay. So it's like,
guduchi is giving our bodies

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backup for dealing
with the stress of a virus.

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Then there's Piper Longum,
or Papali, which kind of

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sounds like something
straight out of a fantasy novel.

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Right. What's its story? Papali is a great
example of how Ayurveda often uses herbs

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in combination to enhance their effects.
It's traditionally used to improve the

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bioavailability of other herbs,
which essentially means it helps your

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body absorb and
utilize them better.

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It's like Papali is the ultimate wingman
for other herbs. So it's boosting their

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effectiveness, like a sidekick
with a superpower.

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I'm also curious about Kata,
the traditional

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Indian herbal decoction.
I remember hearing

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about it during the
pandemic. You're right,

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Kata received a lot of attention.
It's a blend of herbs and spices,

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often including ginger,
turmeric, black pepper, and holy

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basil, all known for their
immune boosting properties.

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It's like a turbocharged tea that's been
used for centuries to ward off colds and

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infections during the COVID-19 outbreak.
The Indian government even recommended

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Kata to the public as a way
to potentially boost immunity.

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It seems governments were looking
for all the

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help they could get even turning
to these ancient remedies.

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But this all begs the question,

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how do these herbs actually
work? Can't just be magic, right?

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You're right, it's not magic,

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although it can sometimes
feel that way. Plants

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produce a vast array of
compounds called secondary

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metabolites as part of their
natural defense mechanisms.

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Think of it this way.

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Plants can't run away from predators
or fight back in the same way animals do,

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so they've evolved these chemical
compounds to protect themselves.

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So they're like tiny warriors
armed with chemical weapons?

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Exactly. And what's fascinating is
that many of

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these compounds which help
plants survive and

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thrive also have beneficial
effects on human health.

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We've identified
thousands of these

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secondary metabolites,
and we're just beginning

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to scratch the surface
of their potential.

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It's like we're borrowing
their superpowers.

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The research mentioned four key
groups of these

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plant compounds, terpenes, phenolics,
and polyphenols, glycosides, and alkaloids.

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What can you tell us about them?

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Each group has its own
unique mechanisms of action,

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and that's what makes
this field of so exciting.

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For example, terpenes are
those wonderfully fragrant

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compounds found
in essential oils.

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They give pine needles, lavender, and
citrus fruits their characteristic sense.

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But here's where it
gets really interesting.

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Some terpenes have been
shown to exhibit antiviral activity.

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They can actually interfere with the virus's
ability to bind to and enter our cells,

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essentially disarming them. So they're
like tiny bouncers

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blocking the virus from
getting into the party.

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I like that analogy.
Then we have glycosides,

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a diverse group of compounds often

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known for their medicinal
properties. One intriguing

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example is glycerizin
found in licorice root.

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What licorice? I like the candy.
The very same licorice

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root has a long history of use in
traditional medicine. Glucorizin is known for

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its anti-inflammatory effects,
and there's some early

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research suggesting
it might also inhibit the

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replication of certain viruses,
including coronaviruses.

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Okay, now I'm picturing licorice whips as
tiny superheroes fighting off viruses.

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This is wild. What about
the other compounds?

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Well, we also have
phenolics and polyphenols,

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which are powerful antioxidants found
in many fruits,

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vegetables, and teas. One well-known example
is corsetin found in foods like berries,

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onions, and apples.
Corstin has demonstrated

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antiviral activity against a
range of viruses

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and researchers are exploring
its potential

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against COVID-19 as well.
So it's like these

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compounds are boosting our
defenses from the inside out.

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What about alkaloids? Those
sound a bit more intense.

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Alkaloids are a fascinating group.
They include some potent compounds,

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some of which are already used in
modern medicine. One example mentioned

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in the research is culticine,
a medication traditionally

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used to treat gout,
which is a type of inflammatory arthritis.

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Culticine has shown potential in reducing

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inflammation associated with COVID-19,
and researchers are investigating

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its antiviral
properties as well.

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It's incredible to think that these compounds
found in planets all around us might

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hold the key to fighting
a global pandemic.

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This is definitely making me
rethink my grocery list.

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It's certainly an area
ripe for further exploration.

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However, it's
crucial to remember

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that we're still in the early stages of
research. While these findings are promising,

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more studies are needed to confirm these
effects and to determine the appropriate

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dosages and forms of administration.
It's important not to jump to

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conclusions or self-medicate
based on preliminary findings.

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We don't want people raiding
their spice cabinets just yet.

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But speaking of things we consume,
this deep dive also explored the role of

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functional foods in supporting
our immune systems.

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Yes, functional
foods are fascinating.

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These are foods that go
beyond basic nutrition,

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offering additional health benefits
due to their

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unique composition of vitamins,
minerals, antioxidants,

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and other bioactive compounds.

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Think of them as everyday
foods with superpowers.

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Okay, I'm all ears. Give us the
rundown on these superfoods.

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What kind of things are
we talking about here?

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Well, you know me, I'm always

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game to hear about
foods with superpowers. So

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give me the rundown
on these functional foods.

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Okay, so think about foods that
are naturally rich in vitamins,

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minerals, antioxidants,

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things we often consider, you know,
quote-unquote, immune boosting.

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Right, for example,

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vitamin D plays a critical role
in regulating our immune response.

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Right. Vitamin D,
we always hear about that,

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especially during flu season.

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Exactly. And studies have shown that
adequate vitamin D levels might be linked to

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less severe COVID-19 outcomes. Okay.
It's not a cure-all. Right.

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But it highlights the importance

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of a well-rounded
approach to health. It makes

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you think about how
interconnected everything is,

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what we eat our immune systems and how
our bodies respond to threats like viruses.

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Right.

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It's all part of the same system.
Precisely. Then there's vitamin C,

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another powerhouse nutrient.

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It's a potent antioxidant and
plays a crucial

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role in supporting various
immune functions.

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Yeah. Vitamin C always seems to be the go
-to when we're feeling under the weather.

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And for good reason,
while more research is needed to

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understand its specific effects on COVID-19,
some studies suggest that vitamin C

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might help manage the
excessive inflammatory

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response that can occur
with the virus. So it's

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like it's helping our bodies
keep things in check,

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not overreacting to
the virus. What about

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zinc? I know that's
important for immunity too.

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Absolutely. Zinc is essential for
immune cell development and function.

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And there's some evidence to suggest
that zinc might even interfere with

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the virus's ability
to replicate.

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Again, it's not about one
single nutrient being a

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magic bullet, but rather
about supporting our bodies

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with the tools they need
to function optimally.

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It's like we're talking about
building a fortress

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from the inside out. Yeah. Strong
walls, well-equipped defenses.

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That's what these
nutrients are helping us do.

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I love that analogy. And we can't forget
about the importance of healthy fats,

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specifically omega-3 fatty acids.
They're known for

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their anti-inflammatory properties
and have

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been shown to play a role in
supporting immune regulation.

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Right. Omega-3s,
those are the ones we

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get from fatty fish like
salmon, right? Exactly.

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Also, flax seeds, chia seeds,
and walnuts are great sources.

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It's fascinating to consider how
incorporating these foods into our diets

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might contribute to a more
resilient immune system.

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It's like we've had an
army of microscopic allies

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all along hidden in plain
sight in our kitchens.

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So as we wrap up this deep dive,

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what are the key takeaways you
hope our listeners walk away with?

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Well, firstly,

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I think it's crucial to remember that this
research is still emerging. It's exciting,

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but we need more studies to
confirm these findings and

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understand the best ways to
apply this knowledge.

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Absolutely. We don't
want people ditching

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their medications or
trying to treat themselves

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with herbs they find growing
in their backyard.

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Always consult with a
qualified health care

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professional before making any
health decisions.

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I couldn't agree more.
It's about having informed

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conversations with health care providers
and making choices

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that align with individual
needs and circumstances.

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On that note, I want to emphasize that this
deep dive wasn't about presenting quick

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fixes or miracle cures.
It was about exploring

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the fascinating intersection of
ancient wisdom

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and modern science and opening our
minds to the possibilities

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that exist when we look
to nature for answers.

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Precisely, it's about
appreciating the intricate ways

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in which our bodies interact with the natural
world and recognizing the potential of

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these traditional remedies as
valuable tools in

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our collective health toolkit.
It's been an incredible

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journey from exploring ancient
healing systems

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to delving into the molecular
world of plant compounds.

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What started as a question about herbs

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and COVID-19 has opened up
a whole new perspective

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on the interconnectedness of
our health and the natural world.

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It's a reminder that there's always
more to learn and that nature holds a

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wealth of wisdom waiting
to be unlocked. And

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that's what makes these
deep dives so rewarding.

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Thank you for joining
us on this exploration

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of oral medicine and
its potential role in a

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modern pandemic. Until next time,
stay curious.