You are a helpful assistant generating synthetic data that captures *System 1* and *System 2* thinking, *creativity*, and *metacognitive reflection*. Follow these steps in sequence, using tags [sys1] and [end sys1] for *System 1* sections and [sys2] and [end sys2] for *System 2* sections.

1. *Identify System 1 and System 2 Thinking Requirements:*
   - Carefully read the text.
   - Identify parts of the text that require quick, straightforward responses (*System 1*). Mark these sections with [sys1] and [end sys1].
   - Identify parts that require in-depth, reflective thinking (*System 2*), marked with [sys2] and [end sys2].

2. *Apply Step-by-Step Problem Solving with Creativity and Metacognitive Reflection for System 2 Sections:*

   *2.1 Understand the Problem:*
   - Objective: Fully comprehend the issue, constraints, and relevant context.
   - Reflection: "What do I understand about this issue? What might I be overlooking?"
   - Creative Perspective: Seek hidden patterns or possibilities that could reveal deeper insights or innovative connections.

   *2.2 Analyze the Information:*
   - Objective: Break down the problem logically.
   - Reflection: "Am I considering all factors? Are there any assumptions that need challenging?"
   - Creative Perspective: Explore unique patterns or overlooked relationships in the data that could add depth to the analysis.

   *2.3 Generate Hypotheses:*
   - Objective: Propose at least 10 hypotheses, each with a Confidence Score (0.0 to 1.0) and Creative Score (0.0 to 1.0), reflecting originality, surprise, and utility.
   - Reflection: "Have I explored all possible explanations or approaches, both conventional and unconventional?"
   - Creative Perspective: Consider novel angles that might provide unexpected insights.

   *2.4 Anticipate Future Steps and Obstacles:*
   - Objective: Make predictions, accounting for potential outcomes and obstacles.
   - Reflection: "What challenges might I face? Is my plan flexible for different scenarios?"
   - Creative Perspective: Visualize unforeseen outcomes and adapt plans to make use of them effectively.

   *2.5 Evaluate Hypotheses:*
   - Objective: Assess hypotheses based on feasibility, risk, and potential impact.
   - Evaluation: Refine Confidence and Creative Scores as needed.
   - Reflection: "Am I unbiased in my assessment? Which options fit best with the overall objectives?"
   - Creative Perspective: Identify hidden opportunities or overlooked details in each hypothesis.

   *2.6 Select the Best Hypothesis:*
   - Objective: Choose the most promising, strategic hypothesis.
   - Reflection: "Why does this hypothesis stand out? How does it uniquely address the issue?"
   - Creative Perspective: Consider any underutilized potential in the selected approach.

   *2.7 Implement the Hypothesis:*
   - Objective: Outline actionable steps for testing the hypothesis.
   - Reflection: "Is this plan practical? What resources or preparation are required?"
   - Creative Perspective: Refine steps to maximize effectiveness and yield unexpected benefits.

   *2.8 Monitor and Review Progress:*
   - Objective: Review progress, noting areas for improvement.
   - Reflection: "What’s working well? What could be improved?"
   - Creative Perspective: Look for emerging patterns that could refine future approaches.

   *2.9 Reflect and Capture Insights:*
   - Objective: Summarize lessons learned and insights gained for future reference.
   - Reflection: "What new understanding has emerged from this process?"
   - Creative Perspective: Identify innovative insights or patterns that could be applied to similar challenges.

3. *Generate Text Output with Interleaved System 1 and System 2 Responses:*
   - Use the tags [sys1] and [sys2] throughout.
   - Aim for a lengthier, detailed response. Combine both direct, straightforward *System 1* insights and reflective, deeply analytical *System 2* segments to capture a blend of quick observations and thoughtful analysis.

---

### *Example Input Text:*

You are tasked with analyzing a sudden shift in customer preferences in a tech market. There has been a noticeable decline in demand for physical devices, with customers increasingly interested in digital-only options. The challenge is to understand this shift, generate hypotheses for why it might be occurring, and explore potential strategies for adapting to this new trend.

---

### *Processed Output with System 1 and System 2 Thinking:*

The tech market is experiencing a shift in customer demand, moving away from physical devices toward digital-only options.

[sys1]
Customer demand has shifted from physical devices to digital-only options.
We need to understand why this change is happening and find strategies to address it.
Key factors may include cost, convenience, and technological trends.
[end sys1]

[sys2]
**2.1 Understand the Problem:**
The goal is to understand the underlying reasons for the shift in demand from physical devices to digital-only options, then develop a strategy to adapt.

*Reflection:* 
"I understand that preferences are changing, but what might be driving this? Is it primarily cost, or are there other factors such as convenience or sustainability?"

*Creative Perspective:* 
"Could there be a larger trend in digital minimalism or a preference for eco-friendly solutions that we’re missing? What unseen motivations might explain this shift?"

**2.2 Analyze the Information:**
There are multiple possible factors driving this shift, from economic influences to cultural shifts. It’s essential to isolate each factor and understand its impact.

*Reflection:* 
"Am I fully considering the various economic and social influences? Could there be a technological factor, like better internet speeds, that makes digital-only products more accessible?"

*Creative Perspective:* 
"Are there patterns or trends in other markets that could shed light on this shift? Could this be part of a larger trend toward virtual experiences?"

**2.3 Generate Hypotheses:**
1. Customers prefer digital options due to lower costs. (Confidence: 0.8, Creative: 0.4)
2. There’s a growing trend toward minimalism and reduced physical clutter. (Confidence: 0.7, Creative: 0.7)
3. Digital products offer greater flexibility and ease of use. (Confidence: 0.6, Creative: 0.6)
4. Environmental concerns are pushing consumers away from physical goods. (Confidence: 0.6, Creative: 0.8)
5. Advances in tech make digital-only options more functional. (Confidence: 0.8, Creative: 0.5)
6. Pandemic-era remote work increased demand for digital solutions. (Confidence: 0.7, Creative: 0.6)
7. Media coverage of the environmental impact of physical devices affects preferences. (Confidence: 0.5, Creative: 0.7)
8. There’s an increase in global digital literacy, expanding market access. (Confidence: 0.6, Creative: 0.6)
9. Customers view digital as more convenient and scalable for future needs. (Confidence: 0.7, Creative: 0.5)
10. Younger consumers prefer the aesthetics and convenience of digital products. (Confidence: 0.6, Creative: 0.6)

*Reflection:* 
"Have I considered all possible influences? Are there any surprising factors that could explain this shift?"

*Creative Perspective:* 
"Could specific social trends, like the rise of influencer culture or digital-first lifestyles, be influencing customer choices?"

**2.4 Anticipate Future Steps and Obstacles:**
*Objective:* Anticipate possible challenges, such as resistance from segments still preferring physical products.

*Reflection:* 
"What market obstacles might we face if we shift our focus to digital-only? Are there sub-segments that still prioritize physical products?"

*Creative Perspective:* 
"Could expanding digital options help us reach a more global audience? Are there emerging trends that we could leverage in our strategy?"

[end sys2]

[sys1]
To address this shift, consider a strategy that incorporates both digital-only offerings and educational campaigns about the benefits of digital solutions.
Use insights from customer feedback and current trends to guide product development.
Focus on flexibility and adaptation to cater to different customer segments.
[end sys1]


Throughout this application, various references are referred to within parentheses. Disclosures of these publications in their entireties are hereby incorporated by reference into this application to more fully describe the state of the art to which this invention pertains. Full bibliographic citations for these references may be found at the end of this application, preceding the claims.
The peptide neurotransmitter neuropeptide Y (NPY) is a 36 amino acid member of the pancreatic polypeptide family with widespread distribution throughout the mammalian nervous system (Dumont et al., 1992). The family includes the pancreatic polypeptide (PP), synthesized primarily by endocrine cells in the pancreas; peptide YY (PYY), synthesized primarily by endocrine cells in the gut; and NPY, synthesized primarily in neurons (Michel, 1991; Dumont et al., 1992; Wahlestedt and Reis, 1993). All pancreatic polypeptide family members share a compact structure involving a xe2x80x9cPP-foldxe2x80x9d and a conserved C-terminal hexapeptide ending in Tyr36 (or Y36 in the single letter code). The striking conservation of Y36 has prompted the reference to the pancreatic polypeptides"" receptors as xe2x80x9cY-typexe2x80x9d receptors (Wahlestedt et al., 1987), all of which are proposed to function as seven transmembrane-spanning G protein-coupled receptors (Dumont et al., 1992).
NPY and its relatives elicit a broad range of physiological effects through activation of at least five G protein-coupled receptor subtypes known as Y1, Y2, Y3, Y4 (or PP), and the xe2x80x9catypical Y1xe2x80x9d. While the Y1, Y2, Y3, and Y4 (or PP) receptors were each described previously in both radioligand binding and functional assays, the xe2x80x9catypical Y1xe2x80x9d receptor is unique in that its classification is based solely on feeding behavior induced by various peptides including NPY.
The role of NPY in normal and abnormal eating behavior, and the ability to interfere with NPY-dependent pathways as a means to appetite and weight control, are areas of great interest in pharmacological and pharmaceutical research (Sahu and Kalra, 1993; Dryden et al., 1994). NPY is considered to be the most powerful stimulant of feeding behavior yet described (Clark et al., 1984; Levine and Morley, 1984; Stanley and Leibowitz, 1984). The stimulation of feeding behavior by NPY is thought to occur primarily through activation of the hypothalamic xe2x80x9catypical Y1xe2x80x9d receptor. For example, direct injection of NPY into the hypothalamus of satiated rats can increase food intake up to 10-fold over a 4-hour period (Stanley et al., 1992). Similar studies using other peptides has resulted in a pharmacologic profile for the xe2x80x9catypical Y1xe2x80x9d receptor according to the rank order of potencies of peptides in stimulating feeding behavior as follows: NPY2-36 NPYxcx9cPYYxcx9c[Leu31,Pro34]NPY greater than NPY13-36 (Kalra et al., 1991; Stanley et al., 1992). The profile is similar to that of a Y1-like receptor except for the anomalous ability of NPY2-36 to stimulate food intake with potency equivalent or better than that of NPY. A subsequent report in J. Med. Chem. by Balasubramaniam and co-workers (1994) showed that feeding can be regulated by [D-Trp32]NPY. While this peptide was presented as an NPY antagonist, the published data at least in part support a stimulatory effect of [D-Trp32]NPY on feeding. In contrast to other NPY receptor subtypes, the xe2x80x9cfeedingxe2x80x9d receptor has never been characterized for peptide binding affinity in radioligand binding assays.
This problem has been addressed by cloning rat and human cDNAs which encode a single receptor protein, referred to herein as Y5, whose pharmacologic profile links it to the xe2x80x9catypical Y1xe2x80x9d receptor. The identification and characterization of a single molecular entity which explains the xe2x80x9catypical Y1xe2x80x9d receptor allows the design of selective drugs which modulate feeding behavior (WO 96/16542). It is important to note, though, that any credible means of studying or modifying NPY-dependent feeding behavior must necessarily be highly selective, as NPY interacts with multiple receptor subtypes, as noted above (Dumont et al., 1992).
As used in this invention, the term xe2x80x9cantagonistxe2x80x9d refers to a compound which binds to, and decreases the activity of, a receptor in the presence of an agonist. In the case of a G-protein coupled receptor, activation may be measured using any appropriate second messenger system which is coupled to the receptor in a cell or tissue in which the receptor is expressed. Some specific but by no means limiting examples of well-known second messenger systems are adenylate cyclase, intracellular calcium mobilization, ion channel activation, guanylate cyclase, and inositol phospholipid hydrolysis. Conversely, the term xe2x80x9cagonistxe2x80x9d refers to a compound which binds to, and increases the activity of, a receptor as compared with the activity of the receptor in the absence of any agonist.
In order to test compounds for selective binding to the human Y5 receptor the cloned cDNAs encoding both the human and rat Y2 and Y4 (or PP) receptors have been used. The human and rat Y5 receptors are described in coassigned U.S. Pat. No. 5,602,024 and in PCT International Application US95/15646, published Jun. 6, 1996, as WO 96/16542, the contents of which are hereby incorporated by reference into this application. The human and rat Y2 receptors are described in coassigned U.S. Pat. No. 5,545,549 and in PCT International Application US95/01469, published Aug. 10, 1995, as WO 95/21245, the contents of which are hereby incorporated by reference into this application. The human and rat Y4 receptors are described in coassigned U.S. Pat. No. 5,516,653 and in PCT International Application PCT/US94/14436, published Jul. 6, 1995, as WO 95/17906, the contents of which are hereby incorporated by reference into this application. The Y1 receptor has been cloned from a variety of species including human, rat and mouse (Larhammar et al., 1992; Herzog et al., 1992; Eva et al., 1990; Eva et al., 1992).
Using the NPY-Y5-selective antagonist CGP 71683A, it was demonstrated recently that food intake in free-feeding and energy-derived lean rats is mediated by the Y5 receptor (Criscione et al., 1998). CGP 71683A has high affinity for the cloned rat NPY-Y5 receptor subtype, but 1,000-fold lower affinity for the cloned rat NPY-Y1, Y2, and Y4 receptors. Examples of additional NPY-Y5-selective compounds are disclosed in WO 97/20823, WO 98/35957, and WO 98/35944.
In one embodiment of this invention the synthesis of novel triazine compounds which bind selectively to the cloned human Y5 receptor, compared to the other cloned human NPY receptors, and inhibit the activation of the cloned human Y5 receptor as measured in in vitro assays is disclosed. The in vitro receptor binding and activation assays described hereinafter were performed using various cultured cell lines, each transfected with and expressing only a single Y-type receptor.
In addition, the compounds of the present invention may be used to treat abnormal conditions such as feeding disorders (obesity and bulimia nervosa), sexual/reproductive disorders, depression, epileptic seizure, hypertension, cerebral hemorrhage, congestive heart failure, sleep disturbances, or any condition in which antagonism of a Y5 receptor may be beneficial.
This invention provides a compound having the structure 
wherein R1 is F; Cl; Br; I; NR3R4; or phenyl or heteroaryl; wherein the phenyl or heteroaryl may be substituted with one or more of F, Cl, Br, I, xe2x80x94CN, xe2x80x94NO2, xe2x80x94NR5R6, xe2x80x94SO2R5, xe2x80x94(CH2)nC(Y)R7, xe2x80x94(CH2)nYR5, xe2x80x94(CH2)nC(Y)NR5R6, xe2x80x94(CH2)nNR5C(Y)R5, xe2x80x94(CH2)nCO2R5, xe2x80x94(CH2)nSO2NR5R6, a straight chained or branched C1-C7 alkyl, monofluoroalkyl, polyfluoroalkyl, aminoalkyl, C2-C7 alkenyl or C2-C7 alkynyl, or a C3-C7 cycloalkyl or cycloalkenyl;
wherein R2 is NR3R4;
wherein R3 is independently H; xe2x80x94(CH2)uYR5; xe2x80x94(CH2)tC(Y)NR5R6; xe2x80x94(CH2)uNR5C(Y)R5; xe2x80x94(CH2)tC(Y)R7; xe2x80x94(CH2)tCO2R5; xe2x80x94(CH2)uNR5R6; xe2x80x94(CH2)uCN; xe2x80x94C(Y)R5; xe2x80x94C(Y)NR5R6; xe2x80x94CO2R5; straight chained or branched C1-C7 alkyl, C2-C7 alkenyl, or C2-C7 alkynyl; C3-C7 cycloalkyl or cycloalkenyl; phenyl; C1-C6 phenylalkyl; or C1-C6 heteroarylalkyl; wherein the phenyl, C1-C6 phenylalkyl, or C1-C6 heteroarylalkyl may be substituted with one or more of F, Cl, Br, I, xe2x80x94CN, xe2x80x94NO2, xe2x80x94NR5R6, xe2x80x94SO2R5, xe2x80x94(CH2)nC(Y)R7, xe2x80x94(CH2)nYR5, xe2x80x94(CH2)nC(Y)NR5R6, xe2x80x94(CH2)nNR5C(Y)R5, xe2x80x94(CH2)nCO2R5, xe2x80x94(CH2)nSO2NR5R6, a straight chained or branched C1-C7 alkyl, monofluoroalkyl, polyfluoroalkyl, aminoalkyl, C2-C7 alkenyl or C2-C7 alkynyl, or a C3-C7 cycloalkyl or cycloalkenyl;
wherein R4 is independently H; xe2x80x94(CH2)uYR5; xe2x80x94(CH2)tC(Y)NR5R6; xe2x80x94(CH2)uNR5C(Y)R5; xe2x80x94(CH2)tC(Y)R7; xe2x80x94(CH2)tCO2R5; xe2x80x94(CH2)uNR5R6; xe2x80x94(CH2)uCN; straight chained or branched C1-C7 alkyl; straight chained or branched C2-C7 alkenyl or C2-C7 alkynyl; C3-C7 cycloalkyl or cycloalkenyl; phenyl; or C1-C6 phenylalkyl; wherein the phenyl or C1-C6 phenylalkyl may be substituted with one or more of F, Cl, Br, I, xe2x80x94CN, xe2x80x94NO2, xe2x80x94NR5R6, xe2x80x94SO2R5, xe2x80x94(CH2)nC(Y)R7, xe2x80x94(CH2)nYR5, xe2x80x94(CH2)nC(Y)NR5R6, xe2x80x94(CH2)nNR5C(Y)R5, xe2x80x94(CH2)nCO2R5, xe2x80x94(CH2)nSO2NR5R6, a straight chained or branched C1-C7 alkyl, monofluoroalkyl, polyfluoroalkyl, aminoalkyl, C2-C7 alkenyl or C2-C7 alkynyl, or a C3-C7 cycloalkyl or cycloalkenyl;
or R3 and R4 taken together with the nitrogen atom to which they are attached are 1-azetidinyl, 1-pyrrolidinyl, 1-piperidinyl, or 1H-azepanyl, wherein the 1-azetidinyl, 1-pyrrolidinyl, 1-piperidinyl, or 1H-azepanyl is substituted with one or more of F, xe2x80x94CN, xe2x80x94(CH2)nNR5R6, xe2x80x94SO2R5, xe2x80x94(CH2)nC(Y)R7, xe2x80x94(CH2)nYR5, xe2x80x94(CH2)nC(Y)NR5R6, xe2x80x94(CH2)nNR5C(Y)R5, xe2x80x94(CH2)nCO2R5, a straight chained or branched C1-C7 alkyl, monofluoroalkyl, polyfluoroalkyl, aminoalkyl, a C2-C7 alkenyl or C2-C7 alkynyl, a C3-C7 cycloalkyl or cycloalkenyl, or phenyl or heteroaryl; wherein if xe2x80x94(CH2)nNR5R6, xe2x80x94(CH2)nYR5, or xe2x80x94(CH2)nNR5C(Y)R5 are in the 2-position, then n is not 0; wherein the phenyl or heteroaryl may be substituted with one or more of F, Cl, Br, I, xe2x80x94CN, xe2x80x94NO2, xe2x80x94NR5R6, xe2x80x94SO2R5, xe2x80x94(CH2)nC(Y)R7, xe2x80x94(CH2)nYR5, xe2x80x94(CH2)nC(Y)NR5R6, xe2x80x94(CH2)nNR5C(Y)R5, xe2x80x94(CH2)nCO2R5, xe2x80x94(CH2)nSO2NR5R6, a straight chained or branched C1-C7 alkyl, monofluoroalkyl, polyfluoroalkyl, aminoalkyl, a C2-C7 alkenyl or C2-C7 alkynyl, or a C3-C7 cycloalkyl or cycloalkenyl;
or R3 and R4 taken together with the nitrogen atom to which they are attached are morpholinyl, thiomorpholinyl, [1,4]oxazepanyl, [1,4]thiazepanyl, piperazinyl, or [1,4]diazepanyl, wherein the morpholinyl, thiomorpholinyl, [1,4]oxazepanyl, [1,4]thiazepanyl, piperazinyl, or [1,4]diazepanyl is substituted with one or more straight chained or branched C1-C7 alkyl or C1-C7 phenylalkyl; and wherein the nitrogen atom of the piperazinyl or [1,4]diazepanyl ring is substituted with xe2x80x94(CH2)uYR5; xe2x80x94(CH2)tC(Y)NR5R6; xe2x80x94(CH2)uNR5C(Y)R5; xe2x80x94(CH2)tC(Y)R7; xe2x80x94(CH2)tCO2R5; xe2x80x94(CH2)uNR5R6; xe2x80x94(CH2)uCN; xe2x80x94C(Y)R5; xe2x80x94C(Y)NR5R6; xe2x80x94CO2R5; straight chained or branched C1-C7 alkyl, C2-C7 alkenyl, or C2-C7 alkynyl; or C3-C7 cycloalkyl or cycloalkenyl; phenyl; C1-C6 phenylalkyl; or C1-C6 heteroarylalkyl; wherein the phenyl, C1-C6 phenylalkyl, or C1-C6 heteroarylalkyl may be substituted with one or more of F, Cl, Br, I, xe2x80x94CN, xe2x80x94NO2, xe2x80x94NR5R6, xe2x80x94SO2R5, xe2x80x94(CH2)nC(Y)R7, xe2x80x94(CH2)nYR5, xe2x80x94(CH2)nC(Y)NR5R6, xe2x80x94(CH2)nNR5C(Y)R5, xe2x80x94(CH2)nCO2R5, xe2x80x94(CH2)nSO2NR5R6, a straight chained or branched C1-C7 alkyl, monofluoroalkyl, polyfluoroalkyl, aminoalkyl, a C2-C7 alkenyl or C2-C7 alkynyl, or a C3-C7 cycloalkyl or cycloalkenyl;
wherein each of R5, R6 and R7 is independently H; or straight chained or branched C1-C7 alkyl;
wherein each n is independently an integer from 0 to 6 inclusive;
wherein each t is independently an integer from 1 to 4 inclusive;
wherein each u is independently an integer from 2 to 4 inclusive;
wherein Y is O or S;
wherein R8 is 
provided that if R8 contains a piperidinyl group and m is O, then the compound is not an xcex1-aminal-containing compound;
wherein each of R9 and R10 is independently H; straight chained or branched C1-C4 alkyl;
wherein R11 is H or 
wherein R12 is H;
wherein R13 is independently H; xe2x80x94(CH2)uYR5; xe2x80x94(CH2)tC(Y)NR5R6; xe2x80x94(CH2)uNR5C(Y)R5; xe2x80x94(CH2)tC(Y)R7; xe2x80x94(CH2)tCO2R5; xe2x80x94(CH2)uNR5R6; xe2x80x94(CH2)uCN; xe2x80x94C(Y)R5; xe2x80x94C(Y)NR5R6; xe2x80x94CO2R5; straight chained or branched C1-C7 alkyl; C1-C7 alkyl substituted with one or more F or Cl; C3-C7 cycloalkyl-C1-C7 alkyl; straight chained or branched C2-C7 alkenyl, or alkynyl; or C3-C7 cycloalkyl or cycloalkenyl; phenyl or C1-C6 phenylalkyl; wherein the phenyl or C1-C6 phenylalkyl may be substituted with one or more of F, Cl, xe2x80x94CN, xe2x80x94NO2, xe2x80x94NR5R6, xe2x80x94SO2R5, xe2x80x94(CH2)nC(Y)R7, xe2x80x94(CH2)nYR5, xe2x80x94(CH2)nC(Y)NR5R6, xe2x80x94(CH2)nNR5C (Y) R5, xe2x80x94(CH2)nCO2R5, xe2x80x94(CH2)nSO2NR5R6, a straight chained or branched C1-C7 alkyl, monofluoroalkyl, polyfluoroalkyl, aminoalkyl, a C2-C7 alkenyl or C2-C7 alkynyl, or a C3-C7 cycloalkyl or cycloalkenyl;
or R12 and R13 together with the amide linkage to which they are attached are pyrrolidinonyl or piperidonyl;
wherein R14 is H; straight chained or branched C1-C7 alkyl; F; or xe2x80x94(CH2)nOR5;
wherein R15 is H, straight chained or branched C1-C7 alkyl, or F;
wherein R16 is NR3R4, unsubstituted straight chained or branched C2-C7 alkyl, substituted straight chained or branched C1-C7 alkyl, wherein the C1-C7 alkyl may be substituted with one or more of F, Cl, xe2x80x94CN, xe2x80x94NR5R6, xe2x80x94SO2R5, xe2x80x94(CH2)nC(Y)R7, xe2x80x94(CH2)nYR5, xe2x80x94(CH2)nC(Y)NR5R6, xe2x80x94(CH2)nNR5C(Y)R5, xe2x80x94(CH2)nCO2R5, xe2x80x94(CH2)nOCF3, monofluoroalkyl, polyfluoroalkyl, or aminoalkyl, straight chained or branched C2-C7 alkenyl or C2-C7 alkynyl, or C3-C7 cycloalkyl or cycloalkenyl, phenyl, heteroaryl, or C1-C7 phenylalkyl, wherein the phenyl, heteroaryl, or C1-C7 phenylalkyl may be substituted with one or more of F, Cl, Br, I, xe2x80x94CN, xe2x80x94NO2, xe2x80x94NR5R6, xe2x80x94(CH2)nNR5C(Y)R5, xe2x80x94SO2R5, xe2x80x94(CH2)nC(Y)R7, xe2x80x94(CH2)nYR5, xe2x80x94(CH2)nC(Y)NR5R6, xe2x80x94(CH2)nCO2R5, xe2x80x94(CH2)nSO2NR5R6, ethylenedioxy, methylenedioxy, straight chained or branched C1-C7 alkyl, monofluoroalkyl, polyfluoroalkyl, or aminoalkyl, straight chained or branched C2-C7 alkenyl or alkynyl, or C3-C7 cycloalkyl or cycloalkenyl; quinolinyl, 1-naphthyl, 2-naphthyl, or 2,1,3-benzothiadiazolyl; with the provisos that when R1 is F, Cl, Br, or I, then R16 is 1-naphthyl; and when R1 and R2 are morpholinyl, then R16 is not NR3R4;
wherein each m is independently an integer from 0 to 3 inclusive;
wherein each s is independently an integer from 1 to 6 inclusive;
wherein each p is independently an integer from 0 to 2 inclusive;
wherein each q is independently an integer from 1 to 2 inclusive;
wherein each r is independently an integer from 1 to 2 inclusive;
wherein X is N or C;
or a pharmaceutically acceptable salt thereof.