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    Write a perfect professional academic email toSteven S. Rosenfeld, M.D., Ph.D.,with these biography and research interests and papers " is a neurologist whose research focuses on identifying novel and effective therapeutics to treat glioblastoma, the most common and lethal of primary brain tumors. In particular, Dr. Rosenfeld's laboratory team is developing treatment approaches that target molecular motors — intracellular enzymes that move cells, driving tumor cell invasion, and chromosomes, driving tumor cell proliferation. Dr. Rosenfeld's team has shown that targeting molecular motors with genetic and pharmacologic means in animal models of glioblastoma is well tolerated and effective in prolonging survival, key first steps in getting new therapies into the clinic. Dr. Rosenfeld is also examining how to improve on this therapeutic approach by combining it with established anticancer drugs and radiation therapy.

Focus areas
Molecular motor targeting. Dr. Rosenfeld is focusing on small molecule inhibitory strategies that block glioblastoma invasion and proliferation by targeting mitotic kinesins and myosins that are involved in driving tumor cell invasion and proliferation. He is also interested in understanding how tumor resistance to these therapies develops, and his team has uncovered a novel mechanism for this process that can be reversed with drugs already approved by the U.S. Food and Drug Administration (FDA). He and his team are now exploring how to most effectively combine a molecular motor therapeutic with a drug regimen designed to prevent development of treatment resistance in animal models of glioblastoma.
Enhancing the efficacy of other cytoskeletal targeting therapies. Microtubule-targeting drugs have been successful in treating a variety of other cancers but disappointing for glioblastoma. Dr. Rosenfeld's team has determined that this is partly due to the fact that glioblastomas can enhance the stability of their microtubules through a single post-translational modification — acetylation of a single lysine residue in the alpha tubulin subunit. Dr. Rosenfeld has shown that glioblastoma cells with high levels of tubulin acetylation are resistant to the effects of FDA-approved microtubule depolymerizing drugs, including vinca alkaloids. He has also shown that suppressing the one enzyme that acetylates alpha tubulin — tubulin acetyl transferase (ATAT1) — restores sensitivity to these drugs. His lab is now exploring how to take advantage of this ATAT1 dependency for a therapeutic effect.
Approaching glioblastoma heterogeneity from a therapeutic perspective. The intratumoral heterogeneity that characterizes glioblastoma also provides an obstacle to effectiveness for a second set of tumor therapeutics — kinase inhibitors. Dr. Rosenfeld's lab has shown that glioblastomas consist of subpopulations of tumor cells that depend on different oncogenic kinases, with each subpopulation sensitive to a limited set of kinase inhibitors. Consequently, his lab has found that treatment with one such inhibitor simply allows the other, insensitive tumor cell subpopulations to continue to grow. Dr. Rosenfeld's lab is now studying genetically engineered mouse models of glioblastoma and using a novel ex vivo platform for studying freshly resected human glioblastomas to see how to target each subpopulation in a glioblastoma simultaneously, using kinase inhibitors in combinations or dosing schemes that are individualized to each specific tumor.
Significance to patient care
The general focus of Dr. Rosenfeld's research laboratory is to develop novel therapeutics to treat glioblastoma. This disease remains a death sentence for patients despite more than 50 years of intensive clinical and basic research on glioblastoma. Novel approaches are desperately needed to make an impact on this disease, particularly approaches that are guided by the unique biology of glioblastoma. Dr. Rosenfeld's goal is to introduce the novel therapeutic approaches his lab is developing into phase 0, phase 1 and phase 2 clinical trials for patients.1A novel mechanoeffector role of fibroblast S100A4 in myofibroblast transdifferentiation and fibrosis.
Southern BD, et al. Among authors: rosenfeld ss. J Biol Chem. 2024. PMID: 38072048 Free PMC article.
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Multiplexed single-cell lineage tracing of mitotic kinesin inhibitor resistance in glioblastoma.
Cheng YL, et al. Among authors: rosenfeld ss. Cell Rep. 2024. PMID: 38652658 Free PMC article.
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Glioma-Induced Alterations in Excitatory Neurons are Reversed by mTOR Inhibition.
Goldberg AR, et al. Among authors: rosenfeld ss. bioRxiv. 2024. PMID: 38293120 Free PMC article. Preprint.
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Altered glutamatergic and inflammatory pathways promote glioblastoma growth, invasion, and seizures: An overview.
Feyissa AM, et al. Among authors: rosenfeld ss. J Neurol Sci. 2022. PMID: 36368135 Review.
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5
The mechanism of kinesin inhibition by kinesin-binding protein.
Atherton J, et al. Among authors: rosenfeld ss. Elife. 2020. PMID: 33252036 Free PMC article.
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Nucleotide-free structures of KIF20A illuminate atypical mechanochemistry in this kinesin-6.
Ranaivoson FM, et al. Among authors: rosenfeld ss. Open Biol. 2023. PMID: 37726093 Free PMC article.
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Multiplexed single-cell lineage tracing of mitotic kinesin inhibitor resistance in glioblastoma.
Cheng YL, et al. Among authors: rosenfeld ss. bioRxiv. 2023. PMID: 37745469 Free PMC article. Updated. Preprint.
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8
Myosin 10 Regulates Invasion, Mitosis, and Metabolic Signaling in Glioblastoma.
Kenchappa RS, et al. Among authors: rosenfeld ss. iScience. 2020. PMID: 33299973 Free PMC article.
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The kinesin-5 tail and bipolar minifilament domains are the origin of its microtubule crosslinking and sliding activity.
Nithianantham S, et al. Among authors: rosenfeld ss. Mol Biol Cell. 2023. PMID: 37610838 Free PMC article.
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Protein kinase Cι and SRC signaling define reciprocally related subgroups of glioblastoma with distinct therapeutic vulnerabilities.
Kenchappa RS, et al. Among authors: rosenfeld ss. Cell Rep. 2021. PMID: 34818553 Free PMC article"tell him that I adore him and his works. I really love to work and study under his guidance. Also add scientific details to email that shows my knowledge relevant to his field and try to write it impressively and interestingly with creative manner that he would love to work with me