User: 

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Assistant: In chemistry, the reactivity of compounds is influenced by various factors, and size can play a role in different ways. Generally, larger or bulkier molecules can be either more or less reactive depending on the context:

1. **Steric Effects**: Larger molecules may be less reactive in some reactions due to steric hindrance, which blocks reactive sites (source: [Chemistry Stack Exchange](https://chemistry.stackexchange.com/questions/35013/are-bulkier-molecules-more-likely-to-react)).

2. **Stability and Reactivity**: For radicals, larger molecules could potentially be more stable due to dispersal of charge, affecting reactivity (source: [Chemistry LibreTexts](https://chem.libretexts.org/Bookshelves/General_Chemistry/Book%3A_Structure_and_Reactivity_in_Organic_Biological_and_Inorganic_Chemistry_(Schaller))).

3. **Atomic Size and Reactivity**: Larger atoms within a molecule might be more reactive because they lose electrons more readily (source: [HelpTeaching.com](https://www.helpteaching.com/lessons/1572/factors-affecting-reactivity-of-elements)).

In summary, whether larger compounds are more reactive depends significantly on the specific type of reaction and the molecular context.
User: generally larger size compoounds are more reactive?


 for "larger size molecules are more reactive?":

1.
URL: https://chem.libretexts.org/Bookshelves/General_Chemistry/Book%3A_General_Chemistry%3A_Principles_Patterns_and_Applications_(Averill)/23%3A_Organic_Compounds/23.04%3A_Reactivity_of_Organic_Molecules
Title: 23.4: Reactivity of Organic Molecules - Chemistry LibreTexts
Content: Like carbocations, a tertiary radical (R 3 C·) is <b>more</b> stable than a primary radical (RCH 2 ·). Figure 23.4.1 23.4. 1: Transient Intermediates in Organic Reactions. (a) The simplest carbocation is the methyl cation (CH 3+), which has six valence electrons and is an electrophile. Its structure is trigonal planar, with an sp 2 hybridized carbon ...

2.
URL: https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Basic_Principles_of_Organic_Chemistry_(Roberts_and_Caserio)/02%3A_Structural_Organic_Chemistry/2.02%3A_The_Sizes_and_Shapes_of_Organic_Molecules
Title: 2.2: The Sizes and Shapes of Organic Molecules
Content: This page titled 2.2: The <b>Sizes</b> and Shapes of Organic <b>Molecules</b> is shared under a CC BY-NC-SA 4.0 license and was authored, remixed, and/or curated by John D. Roberts and Marjorie C. Caserio. The <b>size</b> and shape of <b>molecules</b> <b>are</b> as much a part of molecular structure as is the order in which the component atoms are bonded.

3.
URL: https://chemistry.stackexchange.com/questions/35013/are-bulkier-molecules-more-likely-to-react
Title: organic chemistry - Are bulkier molecules more likely to react ...
Content: Usually in organic chemistry I have seen the interpretation bulky = takes up <b>more</b> space and not bulky = heavier. Sure, I consider anything connected to a tert-butyl group to be bulky in the steric sense, for example $\ce { (CH3)3COH}$, where as a functional group at the end of a linear alkane is not (but could have a higher molar mass): $\ce ...

4.
URL: https://socratic.org/questions/how-does-atomic-size-affect-reactivity
Title: How does atomic size affect reactivity? - Socratic
Content: Dec 6, 2014. The <b>larger</b> an atom is, the <b>more</b> <b>reactive</b> it will be. It helps to think about the <b>size</b> of an atom with the location of the electrons and nucleus in mind. You know that protons are positively charged and electrons are negatively charged, therefore there is a level of attraction between these two oppositely charged subatomic particles.

5.
URL: https://chemistry.stackexchange.com/questions/102832/how-does-ring-size-affect-sn2-reactions
Title: organic chemistry - How does ring size affect SN2 reactions ...
Content: From a thermodynamic point of view, cyclopropyl ring would look to be <b>more</b> <b>reactive</b> because of higher ring strain. But the answer comes from looking at the transition state, which determines the Gibbs energy of activation. In transition state, for any general SN2 S N 2 reaction, the non reacting ones substituents would be forced to be in a ...

6.
URL: https://news.cornell.edu/stories/2023/07/bulky-size-frustrates-radical-molecules-boost-chemical-reactions
Title: Bulky size frustrates radical molecules to boost chemical reactions
Content: How to harness the potential of highly <b>reactive</b> radical <b>molecules</b> to work in pairs and spur transformative chemistry? Bulk them up. That is the approach of a new Cornell-led collaboration that attached large fragments to the infamously temperamental <b>molecules</b>, increasing their girth to insulate them from their hyperreactive partners.

7.
URL: https://chem.libretexts.org/Bookshelves/Inorganic_Chemistry/Supplemental_Modules_and_Websites_(Inorganic_Chemistry)/Descriptive_Chemistry/Elements_Organized_by_Block/2_p-Block_Elements/Group_17%3A_The_Halogens/0Group_17%3A_Physical_Properties_of_the_Halogens/Group_17%3A_General_Properties_of_Halogens
Title: Group 17: General Properties of Halogens - Chemistry LibreTexts
Content: This characteristic makes them <b>more</b> <b>reactive</b> than other non-metal groups. Introduction. ... The <b>size</b> of the <b>molecules</b> increases down the group. This increase in <b>size</b> means an increase in the strength of the van der Waals forces. ... In addition, <b>more</b> energy levels are added with each period. This results in a <b>larger</b> orbital, and therefore a ...

8.
URL: http://science.marshall.edu/castella/chm448/chap6.pdf
Title: <span class="result__type">PDF</span> Chapter 6 - The Structure and Reactivity of Molecules
Content: <b>larger</b> than single bonds because of the presence of the off-axis -clouds. As a result, when placing atoms around a <b>molecule</b>, atoms bound to the central atom by a multiple bond are placed in the least crowded positions. This <b>size</b> difference also has some subtle effects. For example, the bond angles in CH4 are all 109.5º as predicted.

9.
URL: https://www.scientificamerican.com/article/react-fast-how-size-determines-rate/
Title: React Fast: How Size Determines Rate | Scientific American
Content: Place the folded paper on a solid surface and use a spoon to carefully crush the tablet into a powder. Keep the powder folded into the paper and set it aside. Use a measuring cup to add about 250 ...

10.
URL: https://courses.lumenlearning.com/suny-mcc-organicchemistry/chapter/factors-that-determine-acid-strength/
Title: Factors That Determine Acid Strength | MCC Organic Chemistry
Content: HI, with a pK a of about -9, is one the strongest acids known. <b>More</b> importantly to the study of biological organic chemistry, this trend tells us that thiols are <b>more</b> acidic than alcohols. The pK a of the thiol group on the cysteine side chain, for example, is approximately 8.3, while the pK a for the hydroxl on the serine side chain is on the ...

11.
URL: https://www.masterorganicchemistry.com/2012/03/07/7-factors-that-stabilize-positive-charge-in-organic-chemistry/
Title: 7 Factors That Stabilize Positive Charge in Organic Chemistry
Content: Simply put, the lower the charge density, the <b>more</b> stable the positive charge will be. For this reason the (ridiculous) case of H 4 O(2+) is far <b>more</b> unstable than H 3 O(+) which is <b>more</b> unstable than neutral H 2 O. 3. Factor #2: The Lower The Electronegativity Of The Atom, The Better It Can Stabilize Positive Charge

12.
URL: https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Supplemental_Modules_(Organic_Chemistry)/Fundamentals/Intermolecular_Forces
Title: Intermolecular Forces - Chemistry LibreTexts
Content: CH 3 NO 2 (61) 101. The melting points of crystalline solids cannot be categorized in as simple a fashion as boiling points. The distance between <b>molecules</b> in a crystal lattice is small and regular, with intermolecular forces serving to constrain the motion of the <b>molecules</b> <b>more</b> severely than in the liquid state.

13.
URL: https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/cssc.202201323
Title: The Diverse Modes of Oxygen Reactivity in Life &amp; Chemistry
Content: The <b>more</b> <b>reactive</b> forms of oxygen (1 O 2, O 3) are usually not stored but generated from 3 O 2 in situ or on-site. 24 The largest single consumer of O 2 is the steel industry, which requires huge quantities of O 2 for the oxidation of carbon and sulfur impurities to volatile CO 2 and SO 2 flue gases.

14.
URL: https://chem.libretexts.org/Bookshelves/General_Chemistry/Book%3A_Structure_and_Reactivity_in_Organic_Biological_and_Inorganic_Chemistry_(Schaller)/III%3A_Reactivity_in_Organic_Biological_and_Inorganic_Chemistry_1/03%3A_Addition_to_Carbonyls/3.25%3A_Relative_Reactivity_of_Carbonyls
Title: 3.25: Relative Reactivity of Carbonyls - Chemistry LibreTexts
Content: Figure 3.25.1 3.25. 1: There is a general rule about cation stability on carbon atoms: a carbocation with <b>more</b> carbons attached to it is <b>more</b> stable than a carbocation with <b>more</b> hydrogens attached to it. This observation is sometimes explained as an inductive effect. The positively charged carbon is <b>more</b> electronegative than the uncharged ...

15.
URL: https://www.helpteaching.com/lessons/1572/factors-affecting-reactivity-of-elements
Title: Factors Affecting Reactivity of Elements - HelpTeaching.com
Content: Fluorine, the most electronegative element, is highly <b>reactive</b> due to its strong electron-attracting ability. <b>Larger</b> atoms tend to lose electrons <b>more</b> readily, exhibiting increased reactivity. Alkali metals and alkali earth metals display high reactivity due to their relatively large atomic <b>sizes</b>.


Assistant: