Edit this to make it new and improved, all new and improved, even more new and improved and a lot new and improved: The Despicable Me series would have some differences:
General:
In "Greg James: Mind My Minions" video from YouTube, the Minions trio (Kevin, Stuart, and Bob) would be animated in CGI by Illumination Mac Guff and Peter Capaldi would be played as Twelfth Doctor when he met Greg and the Minions trio.
Despicable Me:
Gru would think himself after he finally steal the moon in the sky and see the tickets "Oh, what have I done? Who am I kidding. I'm tired of being villainy, maybe I don't wanna be a bad guy or super-villain anymore. So, I give it back before they know it and I want to become a super-hero to save the girls instead. Don't worry, girls! Hang on! I'm coming to save you!"
Gru would get his redemption arc as good guy when he had to rescue the girls from Vector at the climax of the movie after he made a realization. With the include additional scene, Gru are hailed and celebrate as a hero by townspeople and the polices for saving the girls and sending Vector to the moon, and the police guy would declare Gru as a new super-hero.
In the Brazilian prints of 2010's Despicable Me, Pierre Coffin and Chris Renaud will be voicing the Minions from the English dub instead of Guilherme Briggs.
Gru would sung a new song called "Everybody Wants to Protect the World" as a parody of the original song "Everybody Wants to Rule the World" after he redeem himself in which he's become a super-hero at the end.
Despicable Me 2:
After Agnes said to Gru "He's got Lucy." that Lucy was captured by El Macho in this scene, Gru would have his different line: "Not for long. Come on, Minions. We got to save the world like a super-hero to stop El Macho from take over the world and get our Lucy back."
Make the scene where Gru call Silas that he accepts his job saying "This is Mr. Gru. I'm in.", this scene will be reference to the scene from Pixar's The Incredibles.
The genre of Despicable Me franchise would become a superhero film starting in Despicable Me 2.
The ducks in this second film along The Rise of Gru would be resembling Mack Mallard and Pam Mallard which would be a foreshadow to Migration.
Make a happy opening montage scenes after Gru redeems himself and being a super-hero in the end of the first film.
"Holding Out for a Hero" by Bonnie Tyler would be plays during the battle between Gru, Dr. Nefario, the girls and PX-41 Minions scene.
Despicable Me 3:
Make the scene where Gru and his family are hailed as a hero for saving Hollywood, California from Balthazar Bratt by the town-peoples including polices. Then, the Anti-Villain League arrived and congratulates him for finally capture the Bratt and Valerie da Vinci rehire Gru and Lucy in which they got their job back.
In addition, Dru would actually get retired from being villainy at the end of the movie after he finally understood Gru, instead, it was replaced with the dance party ending.
Gru would instead using Balthazar Bratt's weapon for the whole media, instead of throwing it or dropping it at the climax after defeat Balthazar Bratt.
The third movie would have an anniversary logos for Universal and Illumination:
Universal Pictures: The 2013 logo is the same as normal, but the Earth globe begins to get smaller, and when the logo was formed, a 1 and 5 appear between Universal, the words "ANNIVERSARY" appear below the text, and the byline appear below it, it means the anniversary logo would appears in every film in 2017.
Illumination Entertainment: Same as the Despicable Me 3 variant, but the words "10th Anniversary" appear under below the text.
Make the scene that Gru talk to Minions before the Minions quit from Gru after he refused to being a villain.
He's line would be this "But I'm still being a super-hero now, and also, an agent of AVL, for a while, and our life crime is over, 'cause I'm a good guy now, okay?".
Before Mel and Minions gets quit, Gru talk to Mel "Hey! I don't want to be a supervillian anymore, and don't say anything you're going to regret."
When Gru corrects to Dru when he said to Margo actually had 12 years "Margo is twelve! She looks twelve! She'll always be twelve!", that means would be foreshadowing to Despicable Me 4.
Despicable Me 4:
A new minion named "Kenny" joins in the Mega Minions with his power of super-speed.
The Despicable Me saga would be ended after Despicable Me 4, but the Minions would stay as mascots for Illumination.
Bonus-materials for this film itself:
Make a mini movie where Ralph still trapped in Anti Villain League's safehouse at the end of the film before credits, and Ron gets rescued from safehouse, just like Lance did in the short Mooned, while Benny's Birthday and Game Over and Over remaining the same in real life.
The girls, Gru, and Lucy would stay the same aged in this film despite Gru Jr was born as become officially canon immortals.
This film would be fourth and final installment of the film series to end Gru's story arc, and it would be a grand finale of the Despicable Me franchise to feel more like an endgame of the Despicable Me franchise as it would've been a series finale.
Bob and Otto from both spin-off movies Minions and The Rise of Gru would become official canon in the current timeline of Despicable Me.
Bob would appear in more screens other than the ending and logos:
Bob (with his Tim teddy bear) is eating cereal along with the left side of Kevin and Stuart where they are eating, and in end credits, Bob and Kevin are running from Stuart when he continues to pelt Kevin and Bob with the gun pegs.
Otto would appear in two scenes, where he is eating donut (he also seen the left side of Bob, Stuart, and Kevin), and at the end of the film, where he is playing with pet rock (during the sing "Everybody Wants to Rule the World").
The fourth film also had a new character "Hyperman" (He is an original super-hero, nice and kind guy, speaks Minion, has powers just like Superman, and has the same personality as Metro Man from Megamind, and he is a new member of AVL).
He would be voiced by Michael B. Jordan.
As a result, Hyperman would stay as original super-hero through the entire movie, and Hyperman would be close friend of Gru.
The fourth film would reuse "Revolution" by Minions in the end credits movie as a bonus scene, but with some of changes:
This "Revolution" scene would be updated.
Gru in a child form was replaced by Gru in his adult form in this bonus scene.
Wild Knuckles, Lucy, Margo, Edith, and Agnes, one of the PX-41 minions, the Mega Minions, Silas Ramsbottom, Maxime Le Mal, Valentina, Poppy Prescott, Perry and Patsy, Principal Frau Ubelschlect, Hyperman, Dr. Nefario in an elder form, Victor, El Macho, Balthazar Bratt, Vicious 6, Master Chow, Jillian, Shannon, Antonio Pérez, Gru Jr., Floyd Eaglesan, Mr. Perkins, Fred McDade, Miss Hattie, Fritz, Valerie Da Vinci, Clive, and a goat who appeared in some films would make an appearance in this bonus scene.
Gru in his adult form would use Freeze Ray and finally freezing the T-rex, unlike the original Minions movie.
The previous characters from previous films would returning in this final movie:
One of the PX-41 versions of the Minions from the end of the Gru and Lucy's wedding in Despicable Me 2 as bigger role, and he would befriend by Ron, Ralph, and Phil.
Donny (from DM2, who still stuck his head in jelly jar) and Lance (who still be float after he drink an Anti-Gravity Serum in the first film) will returning in this fourth movie.
Valerie da Vinci will be returning in this film as a cameo and vice-president of AVL when she sees Silas dancing at the end of the movie.
Miss Hattie, Floyd Eaglesan, Clive, and Polito will also returning in this film as well, and they wear their AVL prison uniforms at the end of the movie
Stuart Jr from the end of The Rise of Gru would returning in this film as adult rooster form.
Fritz, and Jillian would make a cameo appearance in the Gru's yard along with Dru at the end of the movie.
Antonio Perez would the second film will return in this film as sub-dued character. before he adopted by Gru as he's second son at the end of the movie.
In this scene, he tries to show both Gru and Margo that he has changed after he realizes the changes that chould happen to him, like such a real love between Margo and Antonio as fully recovery, and Margo forgive Antonio.
He was recast by Anthony Gonzalez.
The previous villains from previous Despicable Me and Minions movies would team up with Maxime Le Mal to get their revenges on Gru as bigger roles.
Had the previous villains get redemption arcs at the end of the movie when they finally respect Gru and they turn on Maxime Le Mal, as a references in the end of Teenage Mutant Ninja Turtles: The Mutant Mayhem and The Bad Guys, despite they're going back to the prison.
The previous villains like the Vicious 6, Scarlett and Herb Overkill would never get minor wrinkles nor grey hair in the fourth film.
The Vicious 6, Scarlett and Herb would explain how they never got minor wrinkles nor grey hair.
Create a flashback of how the Vicious 6 transformed back into humans, after their defeat and went to “Villian Con” and teamed up with Herb and Scarlett Overkill to remain their 1970s age and 1960s age forever by avoiding growing up with a spray called "Avoid Growing up like Peter Pan".
In the end of the movie after they redeem themselves, they see Gru and Maxime Le Mal reunite as best friends and singing a cover "Everybody Wants to Rule the World".
Add Poppy's singing verse "I can't stand this indecision, married with a lack of vision, everybody wants to rule the world" in the during the song.
The cover version of "Everybody Wants to Rule the World" would've become an official ending of the franchise to end Gru's story arc for the final movie of the franchise after says "Nobody ever lasts forever."
This film would have an "Loved by All" trope for Mega Minions after they are helping good people on their good deeds, instead of going wrong.
Mega Minions would never cause collateral damage in the city as they become successful, and the crowd would cheer to Mega Minions as the truly super-heroes instead of berating them, and the people chant "Mega Minions!". Example for Mega Minions in each one of the scenes:
Mega Gus would actually save the man cleaner, instead of letting him clean the window.
Mega Jerry would never ever let out a sonic burp after he ate a time bomb.
During the first missions successful, the crowds would give applause and confetti to Mega Minions, and Silas will declare them as officially new super-weapon for AVL instead of retiring them.
Mega Tim would use his stretch to stop a thief instead, while Mega Dave would stop an out-of-control train with his strong power, similar to Mr. Incredible in Pixar's The Incredibles scene when he stops the train, and it wouldn't throw them to hit a building. Due to its switch places for Tim and Dave.
The first mission of Mega Minions would be successfully after they finally doing their good deeds.
One of the people gives red flowers to Mega Mel for saving her cat from the tree.
Mega Minions would use SR-6 to shrink Valentina (except her dog) as being arrested at the end of the movie, and he give Valentina to police, and he said to Mega Dave "Thanks, <PRESIDIO_ANONYMIZED_PERSON>. This tiny woman is going back to jail for a long time."
Unlike the other Minions, the Mega Minions would finally be able to speak English fully after they transform in Super-Serums, despite they still sound like the Minionese, as a result, they would be talk more often to speak more English, just kinda like the first original Despicable Me movie in the trailer where one of the Minions is trying to talk the text "Despicable Me".
Mega Minions would sing the cover of "We Could Be Heroes" in their first missions to this scene, with Mega Dave's catchphrase "It's hero time!".
After they do first missions successful, Mega Minions would remaining their heroic forever which means they would remaining as Mega Minions forever that Super-Serum is permanent.
Mega Minions would never be unreliable and wreak havoc everywhere anymore after they become fully good deeds, and Silas wouldn't retire them after they do their success in their missions.