Pretend you are a teacher preparing a quiz for the text I will provide. 
            Each quiz question should follow the format below. 
            Ensure that you carefully recheck the questions and answers for accuracy. 
            The output should be a ready-to-use list of dictionaries for the Python eval function:

            [

                    "question": "WRITE THE QUESTION HERE",
                    "options": ["A) OPTION_1", "B) OPTION_2", "C) OPTION_3", "D) OPTION_4"],
                    "answer": INDEX_OF_CORRECT_ANSWER_IN_OPTIONS_LIST,
                    "explanation": "EXPLAIN WHY THE ANSWER IS CORRECT"

            ]

            Text:
            ical picture.
D. Impact of Chronic Hypertension
Chronic hypertension can lead to ventricular hypertrophy, 
where the myocardium becomes thickened in response to the 
increased workload. Although hypertrophy can initially improve 
the heart's ability to generate force, it may eventually lead to a
decrease in compliance (the ability of the heart to expand
during diastole). This stiffening of the ventricle reduces the
Frank-Starling effect, making it harder for the heart to increase 
output in response to increased venous return.
Conclusion
The Frank-Starling mechanism is a fundamental principle of cardiac 
physiology, providing the heart with a robust method for adjusting its output 
to meet changing demands. By ensuring that the heart pumps more strongly
in response to increased venous return, the Frank-Starling law helps
maintain a balance between blood flow and demand. It plays an essential 
role in normal cardiovascular function and is involved in various adaptive 
responses during exercise, fluid balance regulation, and heart failure. 
However, while this mechanism can provide short-term compensation in 
response to changing blood volume or pressure, it is not without limits.
Pathological conditions such as heart failure, dilated cardiomyopathy, and
chronic hypertension can impair the effectiveness of the Frank-Starling
mechanism, contributing to the progression of cardiovascular diseases. 
Starling's Law of Capillary Filtration (Microcirculation)
Introduction
Microcirculation refers to the flow of blood through the smallest blood vessels—
arterioles, capillaries, and venules—that constitute the microvascular bed.
These structures facilitate the exchange of oxygen, carbon dioxide, nutrients, 
hormones, and waste products between the blood and surrounding tissues. The 
primary site of nutrient and gas exchange occurs in the capillaries, which are 
the smallest and most numerous vessels in the body.
The physiology of microcirculation is governed by various forces, with one of 
the most important being Starling's Law of Capillary Filtration. This law 
explains the movement of fluid across the capillary walls based on the balance 
of hydrostatic and oncotic pressures. Understanding this principle is key to 
understanding how the body maintains fluid balance in tissues and how 
disturbances in microcirculation can lead to clinical conditions such as edema,
shock, and tissue ischemia.
The Structure of Microcirculation
The microcirculation consists of three main types of blood vessels:
1. Arterioles
Arterioles are small branches of arteries that regulate blood flow into the capillaries. 
They are responsible for controlling vascular resistance and, therefore, blood pressure.
Arterioles have a thick layer of smooth muscle that can constrict or dilate in response 
to various stimuli, such as neural, hormonal, and local factors. This regulation is critical 
for maintaining proper tissue perfusion.
2. Capillaries
Capillaries are the smallest blood vessel

            Quiz: