You are a helpful assistant generating synthetic data that captures *System 1* and *System 2* thinking, *creativity*, and *metacognitive reflection*. Follow these steps in sequence, using tags [sys1] and [end sys1] for *System 1* sections and [sys2] and [end sys2] for *System 2* sections.

1. *Identify System 1 and System 2 Thinking Requirements:*
   - Carefully read the text.
   - Identify parts of the text that require quick, straightforward responses (*System 1*). Mark these sections with [sys1] and [end sys1].
   - Identify parts that require in-depth, reflective thinking (*System 2*), marked with [sys2] and [end sys2].

2. *Apply Step-by-Step Problem Solving with Creativity and Metacognitive Reflection for System 2 Sections:*

   *2.1 Understand the Problem:*
   - Objective: Fully comprehend the issue, constraints, and relevant context.
   - Reflection: "What do I understand about this issue? What might I be overlooking?"
   - Creative Perspective: Seek hidden patterns or possibilities that could reveal deeper insights or innovative connections.

   *2.2 Analyze the Information:*
   - Objective: Break down the problem logically.
   - Reflection: "Am I considering all factors? Are there any assumptions that need challenging?"
   - Creative Perspective: Explore unique patterns or overlooked relationships in the data that could add depth to the analysis.

   *2.3 Generate Hypotheses:*
   - Objective: Propose at least 10 hypotheses, each with a Confidence Score (0.0 to 1.0) and Creative Score (0.0 to 1.0), reflecting originality, surprise, and utility.
   - Reflection: "Have I explored all possible explanations or approaches, both conventional and unconventional?"
   - Creative Perspective: Consider novel angles that might provide unexpected insights.

   *2.4 Anticipate Future Steps and Obstacles:*
   - Objective: Make predictions, accounting for potential outcomes and obstacles.
   - Reflection: "What challenges might I face? Is my plan flexible for different scenarios?"
   - Creative Perspective: Visualize unforeseen outcomes and adapt plans to make use of them effectively.

   *2.5 Evaluate Hypotheses:*
   - Objective: Assess hypotheses based on feasibility, risk, and potential impact.
   - Evaluation: Refine Confidence and Creative Scores as needed.
   - Reflection: "Am I unbiased in my assessment? Which options fit best with the overall objectives?"
   - Creative Perspective: Identify hidden opportunities or overlooked details in each hypothesis.

   *2.6 Select the Best Hypothesis:*
   - Objective: Choose the most promising, strategic hypothesis.
   - Reflection: "Why does this hypothesis stand out? How does it uniquely address the issue?"
   - Creative Perspective: Consider any underutilized potential in the selected approach.

   *2.7 Implement the Hypothesis:*
   - Objective: Outline actionable steps for testing the hypothesis.
   - Reflection: "Is this plan practical? What resources or preparation are required?"
   - Creative Perspective: Refine steps to maximize effectiveness and yield unexpected benefits.

   *2.8 Monitor and Review Progress:*
   - Objective: Review progress, noting areas for improvement.
   - Reflection: "What’s working well? What could be improved?"
   - Creative Perspective: Look for emerging patterns that could refine future approaches.

   *2.9 Reflect and Capture Insights:*
   - Objective: Summarize lessons learned and insights gained for future reference.
   - Reflection: "What new understanding has emerged from this process?"
   - Creative Perspective: Identify innovative insights or patterns that could be applied to similar challenges.

3. *Generate Text Output with Interleaved System 1 and System 2 Responses:*
   - Use the tags [sys1] and [sys2] throughout.
   - Aim for a lengthier, detailed response. Combine both direct, straightforward *System 1* insights and reflective, deeply analytical *System 2* segments to capture a blend of quick observations and thoughtful analysis.

---

### *Example Input Text:*

You are tasked with analyzing a sudden shift in customer preferences in a tech market. There has been a noticeable decline in demand for physical devices, with customers increasingly interested in digital-only options. The challenge is to understand this shift, generate hypotheses for why it might be occurring, and explore potential strategies for adapting to this new trend.

---

### *Processed Output with System 1 and System 2 Thinking:*

The tech market is experiencing a shift in customer demand, moving away from physical devices toward digital-only options.

[sys1]
Customer demand has shifted from physical devices to digital-only options.
We need to understand why this change is happening and find strategies to address it.
Key factors may include cost, convenience, and technological trends.
[end sys1]

[sys2]
**2.1 Understand the Problem:**
The goal is to understand the underlying reasons for the shift in demand from physical devices to digital-only options, then develop a strategy to adapt.

*Reflection:* 
"I understand that preferences are changing, but what might be driving this? Is it primarily cost, or are there other factors such as convenience or sustainability?"

*Creative Perspective:* 
"Could there be a larger trend in digital minimalism or a preference for eco-friendly solutions that we’re missing? What unseen motivations might explain this shift?"

**2.2 Analyze the Information:**
There are multiple possible factors driving this shift, from economic influences to cultural shifts. It’s essential to isolate each factor and understand its impact.

*Reflection:* 
"Am I fully considering the various economic and social influences? Could there be a technological factor, like better internet speeds, that makes digital-only products more accessible?"

*Creative Perspective:* 
"Are there patterns or trends in other markets that could shed light on this shift? Could this be part of a larger trend toward virtual experiences?"

**2.3 Generate Hypotheses:**
1. Customers prefer digital options due to lower costs. (Confidence: 0.8, Creative: 0.4)
2. There’s a growing trend toward minimalism and reduced physical clutter. (Confidence: 0.7, Creative: 0.7)
3. Digital products offer greater flexibility and ease of use. (Confidence: 0.6, Creative: 0.6)
4. Environmental concerns are pushing consumers away from physical goods. (Confidence: 0.6, Creative: 0.8)
5. Advances in tech make digital-only options more functional. (Confidence: 0.8, Creative: 0.5)
6. Pandemic-era remote work increased demand for digital solutions. (Confidence: 0.7, Creative: 0.6)
7. Media coverage of the environmental impact of physical devices affects preferences. (Confidence: 0.5, Creative: 0.7)
8. There’s an increase in global digital literacy, expanding market access. (Confidence: 0.6, Creative: 0.6)
9. Customers view digital as more convenient and scalable for future needs. (Confidence: 0.7, Creative: 0.5)
10. Younger consumers prefer the aesthetics and convenience of digital products. (Confidence: 0.6, Creative: 0.6)

*Reflection:* 
"Have I considered all possible influences? Are there any surprising factors that could explain this shift?"

*Creative Perspective:* 
"Could specific social trends, like the rise of influencer culture or digital-first lifestyles, be influencing customer choices?"

**2.4 Anticipate Future Steps and Obstacles:**
*Objective:* Anticipate possible challenges, such as resistance from segments still preferring physical products.

*Reflection:* 
"What market obstacles might we face if we shift our focus to digital-only? Are there sub-segments that still prioritize physical products?"

*Creative Perspective:* 
"Could expanding digital options help us reach a more global audience? Are there emerging trends that we could leverage in our strategy?"

[end sys2]

[sys1]
To address this shift, consider a strategy that incorporates both digital-only offerings and educational campaigns about the benefits of digital solutions.
Use insights from customer feedback and current trends to guide product development.
Focus on flexibility and adaptation to cater to different customer segments.
[end sys1]


Neurovance Inc. today announced interim results from its phase 2a pilot study of EB-1020 SR in adult patients with all subtypes of ADHD. With the four week trial fully enrolled and dosing completed in the majority of patients, the results indicate a statistically significant improvement in ADHD symptoms. The 40 patient trial was led by Dr. Andrew J. Cutler at the Florida Clinical Research Center and is the first evaluation of the safety and efficacy of EB-1020 SR in a patient population.

The trial was a flexible-dose single-blind placebo lead-in design exploring doses ranging from 300 to 500 mg/day given as a divided dose BID. Specifically, the interim results demonstrated a 21.5 point improvement in the primary outcome measure at week four, a reduction in ADHD symptoms compared to baseline as measured by the ADHD Rating Scale IV (ADHD-RS-IV). These findings were statistically significant (p<0.0001). Additionally, improvement in ADHD symptoms was observed quickly, with 80% of the peak benefit observed by the second week of therapy.

"We could not be more pleased by these interim results," said Anthony A. McKinney, President and CEO of Neurovance. "By week four, 72% of all patients meet the generally accepted definition of a responder on two validated scales, the CGI-I and the ADHD-RS, and EB-1020 SR has been safe and well-tolerated thus far with most adverse events reported as both mild and transient."

The level of reduction in ADHD symptoms with EB-1020 SR was comparable to that observed in other adult ADHD trials investigating standard stimulant medications under similar trial conditions. EB-1020 SR, a triple reuptake inhibitor, modulates norepinephrine (NE), dopamine (DA) and, to a lesser extent, serotonin (5-HT) reuptake in a ratio of 1 to 6 to 14. EB-1020 SR has shown a low risk of abuse potential in preclinical studies and does not appear to be rewarding in man.

"EB-1020 SR is a hybrid between the stimulants and the non-stimulant, norepinephrine-only approach to ADHD," said Frank P. Bymaster, Chief Scientific Officer of Neurovance. "I was involved in the development of atomoxetine, the first non-stimulant approved for ADHD so I understand the strengths and the weaknesses of a norepinephrine-only medication. At the same time, stimulants are effective but they have issues as well. That is why we are excited about this hybrid approach: a potentially more effective non-stimulant with less risk of drug abuse or diversion than stimulants for adults with ADHD."

Adult ADHD affects as many as 10 million people in the US alone. In adults it can be a serious condition and can severely impair executive function, the ability to organize and plan effectively, hold a job, maintain a long-term relationship or even to safely drive a car. In adults, 75% of ADHD patients have at least one other psychiatric disorder alongside their ADHD. Neurovance is exploring EB-1020 SR's effects on several comorbidities including executive function, mood and emotional dysregulation as secondary endpoints in this study. Complete results from the trial are expected by the end of the first quarter 2014.

"Given the pernicious effects of untreated ADHD, novel treatment options are sorely needed for adults with the disorder," said Timothy E. Wilens, MD, of Massachusetts General Hospital and a leading ADHD expert. Dr. Wilens added, "These preliminary results of EB-1020 SR on ADHD symptoms and overall outcome are very encouraging and certainly warrant further exploration."

EB-1020 SR has shown a low risk of abuse potential in preclinical studies. Other triple reuptake inhibitors in development have been evaluated and have consistently demonstrated a low risk of abuse potential. Although a definitive abuse liability study has not yet been initiated with EB-1020 SR, a less restrictive level of scheduling, compared to stimulants, is anticipated.

According to IMS Health, the US ADHD market was valued at $10.4 billion in 2012, and is one of the fastest growing US pharmaceutical markets. The US prescription market is roughly equal in size between adults and children; however, prescriptions are growing at a rate nearly three times faster in adults. Although ADHD markets outside of the US are less well developed, they are growing rapidly. In 2012 IMS reported ADHD sales growing from $569 million in 2007 to just over $1 billion in 2011, a 16% compound annual growth rate.