When Romania entered World War II on June 22, 1941, Sănătescu was the commanding officer of the 4th Army Corps. He participated for two years in the battles on the Eastern Front, standing out in the Battle of Odessa and the Battle of Stalingrad. He was decorated on November 7, 1941, with the "Order of the Star of Romania " with swords in the rank of Grand Officer with the ribbon of "Military Virtue" "for the dexterity with which he led the troops of the Army Corps in the battle of Odessa. Acting with all his might, he definitively defeated the enemy resistance in the South Tătarca region, entering Odessa." He was promoted to the rank of Army Corps General on January 24, 1942.