On 10 February 1916, "S50" took part in a sortie by 25 torpedo boats of the 2nd, 6th and 9th Torpedo-boat Flotillas into the North Sea. The sortie led to an encounter between several German torpedo boats and British minesweepers off the Dogger Bank, which resulted in the British minesweeper being torpedoed and sunk by ships of the 2nd Flotilla. "S50" took part in the Bombardment of Yarmouth and Lowestoft on 24–25 April 1916, where she formed part of the escort for the battlecruisers of the I Scouting Group. At the Battle of Jutland on 31 May–1 June 1916, "S50" was part of the 12th Half-Flotilla, 6th Torpedo Boat Flotilla, again operating in support of the I Scouting Group. The 12th Half Flotilla attempted a torpedo attack against the battlecruisers of the British 3rd Battlecruiser Squadron at about 19:00 CET (i.e. 18:00 GMT), with "S50" firing a single torpedo which circled rather than running straight. None of the four torpedoes launched by the Flotilla in this engagement found their target. Later that evening, "S50", and were sent to the rear of the retiring German fleet in order to carry out night torpedo attacks on the British fleet. They were fired on by the 2nd Light Cruiser Squadron at about 21:52 CET and turned away, with "S50" being hit by a British six-inch (152-mm) shell, which although it did not explode, knocked out one of her boilers and reduced her speed to . She returned to the main German fleet while "V69" and "V46" continued on their patrol. At about 02:00 CET on 1 June, "S50" was sailing in the vicinity of the battleship when the British 12th Destroyer Flotilla launched a torpedo attack on the German battleships. The German battleships responded with heavy fire, and when "S50" turned towards the British ships, she was fired on by her own side, and a German shell hit one of her ventilators. The pre-dreadnought battleship was sunk with the loss of all hands by a single torpedo from the British destroyer in this attack.