In Game 4 of the World Series, Uehara picked off St. Louis Cardinals pinch runner Kolten Wong for the last out of a 4–2 Red Sox win. In Game 5, he recorded his seventh save of the postseason, tying the record for most saves in a single postseason. (The next year Greg Holland matched his record for saves in the playoffs, tying John Wetteland, Robb Nen, Troy Percival, and Brad Lidge.) Uehara threw the winning pitch in the series, closing out the 6–1 win over the Cardinals in Game 6 at Fenway Park, Boston. During Boston's post-win celebrations on the field, David Ortiz playfully lifted Uehara over his shoulder after games five and six.