Between 1954 and 1956 Salvadori drove a Maserati 250F in Formula One for Syd Greene's Gilby Engineering team, taking a numerous good results in predominantly non-championship F1 races, with one entry for Officine Alfieri Maserati in the Großer Preis der Schweiz where he did not start and the car was driven by Sergio Mantovani. It was in the 1956 RAC British Grand Prix at Silverstone when only a similarly 250F mounted Moss shaded him and a possible victory was lost to a fuel line problem, marked him out as a potential top-level driver. However, he remained particularly active in domestic motor sport and in sports cars for Aston Martin.