Antikyra was destroyed and rebuilt during the 4th- and 3rd-century BC wars of Macedonia and Rome and following a 7th-century AD earthquake. During the 14th century, it was held by Catalan mercenaries. Politically it was a primary port of ancient Phocis. in modern times it became a municiplality of Boeotia, along with Distomo and Arachova. During the Kallikrates reform of 2011, which sought to decrease governmental substructure by combining municipalities, it was made a unit of the new unified municipality of Distomo-Arachova-Antikyra.