The Mets clinched their spot in the playoffs, and Reyes experienced the postseason for the first time in his career. He made his playoff debut on October 4, 2006 against the Los Angeles Dodgers in the 2006 National League Division Series. Though he hit just .167 for the series, he came up big in key situations, scoring the winning run in Game 1, driving in the go-ahead run in Game 2, and knocking in the game-tying run in the 6th inning of Game 3. In Game 6 of the 2006 National League Championship Series against the St. Louis Cardinals and facing elimination, Reyes hit a leadoff home run in the first inning to jump start his team and help force a deciding Game 7, which the Mets went on to lose, 3–1.