A midfielder, Sperone played his entire playing career with Torino, the team in which he collected 138 appearances (one in Coppa Italia) in nine consecutive seasons. He began his career in the first team on 10 February 1924 in a home game against Novese (5–0); winning the title in 1926–27 (later revoked) and in 1927–28. The last match he played was a loss away to Milan on 29 May 29, 1932, 6–1.