With Sergio Agüero preferred as the lone centre-forward in a three-man Argentine attack, Higuaín made his first start of the 2015 Copa América in the final group match, against Jamaica in Viña del Mar. Winning his 50th cap, he scored the only goal of the game in the 11th minute when set up by Ángel Di María, sending Argentina through to the quarter-finals as group winners. On 30 June, he scored the final goal of Argentina's 6–1 win over Paraguay in the semi-finals, two minutes after coming on in place of Agüero. On 4 July, Higuaín was one of two Argentina players to fail to convert their kicks in a penalty shootout loss to Chile in the 2015 Copa América Final, blasting his attempt over the crossbar; during regulation time he had previously been provided with a late goalscoring opportunity, but failed to convert Ezequiel Lavezzi's low cross.