Dimitriou played club football for Panathinaikos, appearing in 254 league matches in more than a decade with the club. He was runner up at 1971 European Cup Final but he didn't play due to injury. He played at 1971 Intercontinental Cup. Dimitriou won 4 Greek championships (1969, 1970, 1972, 1977) and 2 Greek cups (1969, 1977).