Mariana and her family served in the Ten Years' War, Little War (1868–78) and the War of 1895. Jose and Antonio Maceo Grajales, sons of Mariana, served as generals in the Liberation Army from 1868 through 1878. During her time serving in the war, Mariana ran hospitals and provision grounds on the base camps of her son Antonio, frequently entering the battlefield to aid wounded soldiers, both Spaniard and Cuban.