Following the earthquake that destroyed Catania and the Val di Noto in 1693, Giuseppe Asmundo was one of the leaders of urban and cultural rebirth in the affected areas. In Catania, among other works, he rebuilt the girls' school Conservatorio delle Verginelle as a refuge for needy orphan girls and contributed, through the prior Bartolomeo Asmundo, to the construction of the church of the Immacolata Concezione ai Minoritelli. In Noto, he was the commissioner general for reconstruction. Together with Giuseppe Lanza (vicar general for the Val di Noto), Giovanni Montalto, Sipione Coppola, and the Jesuit architect Angelo Italia, he was one of the architects of the form of renaissance that took the name Sicilian Baroque.