Collins-Muhammad was a known leader in the protest movement following the 2014 death of teenager Michael Brown in Ferguson, Missouri. He expressed criticism of police militarization and the way the crisis was handled within the community. During the protests, Collins-Muhammad was among the protesters who were tear-gassed by law enforcement and policing agencies. He assisted in the organizing of rallies, events, and protest demonstrations calling for the resignation of Ferguson Police Chief Tom Jackson and the immediate arrest of police officer Darren Wilson. He was fired in 2014 from the Village of Uplands Park in St. Louis County for making inflammatory remarks on national television about the shooting of two St. Louis area police officers. Fellow Ferguson protester and Black Lives Matter surrogate Tory Russell is a known associate of Collins-Muhammad and served as his campaign manager.