Molinari has been in the top 100 of the World Rankings continuously since the end of 2008. Playing with his brother Edoardo, they won the 2009 Omega Mission Hills World Cup, Italy's only win in the event. Molinari won the 2010 WGC-HSBC Champions and has represented Europe in three winning Ryder Cup teams, in 2010, 2012 and 2018.