On June 20, 2016, Jansen picked up his 162nd career save against the Washington Nationals, breaking the all-time franchise record held by Éric Gagné. He was also selected to the National League team for the 2016 Major League Baseball All-Star Game, his first all-star selection. On August 24, 2016, Jansen tied Jim Brewer's franchise record for strikeouts by a reliever with the 604th of his career. In 71 games, he was 3–2 with a 1.83 ERA and 47 saves, earning him the Trevor Hoffman National League Reliever of the Year Award. Of all MLB pitchers, he held right-handed batters to the lowest batting average, .107 (in 30 or more innings). In the 2016 NLDS against the Washington Nationals, Jansen pitched in four games and worked innings, allowing four runs and saving two games. In the 2016 NLCS against the Chicago Cubs he pitched innings over three games, with one save, and struck out 10 while only allowing one hit.