A trio of matches without dropping a set saw Lewis cruise in to the quarter-finals of the 2016 World Championship and he then overcame Peter Wright 5–2 and was 5–0 up on Raymond van Barneveld in the semis. The Dutchman threatened a comeback as he reduced the gap to 5–3, but Lewis captured the set he needed to reach his third World Championship final. In a rematch of the 2011 final he faced Gary Anderson and Lewis lost 7–5, a reversal of the scoreline from five years ago. 34 180s were thrown which is a record in a professional match. He won the first UK Open Qualifier with a 6–2 victory over Phil Taylor with an average of 110 and was knocked out in the fifth round of the UK Open itself, 9–7 by Jelle Klaasen. Lewis ended Michael van Gerwen's 27 match wins in a row when he knocked out him 6–4 in the quarter-finals of the first Players Championship event of the year. He then overcame Gary Anderson 6–3 and was 5–3 ahead of Peter Wright in the final, but lost 6–5 without getting a dart for the match. Lewis advanced to the Premier League Play-offs for the first time in five years, which included a nine darter against James Wade in week 11, but he was easily defeated 10–4 by Van Gerwen.