President Hitchcock was married in December 1837, to Miss Clarissa Maria Ford, daughter of Stephen Ford, of Burton, Ohio. He had eleven children, of whom five, with their mother, survived him. His daughter Sarah Melissa Hitchcock married Thomas Day Seymour. Two of their sons were graduates of Western Reserve College in 1859; the elder of whom was a clergyman, and the younger was killed at the battle of Stone River, in Tennessee, December 31, 1862.