Even though the Onodera had managed to defeat or at least stall numerous invasions by outsiders over time, their position finally became untenable in 1600. In the war for the control over Japan between the forces loyal to Tokugawa Ieyasu and Toyotomi Hideyori, Onodera Yoshimichi had chosen to side with the latter. The other lords in the Akita region instead pledged allegiance to the Tokugawa cause. Toyotomi Hideyori's followers were decisively defeated at Sekigahara, but Yoshimichi refused to give up. This provided the Mogami, who had sided with Tokugawa Ieyasu, with the chance to subjugate the now isolated Onodera. They invaded with a large army in late 1600 and quickly overran the Onodera, forcing Yoshimichi to surrender, whereupon he was exiled.