Khon Kaen Hospital was constructed in 1947 and was opened on 1 January 1951, as 3 one-storey wooden buildings. Between 1957-1967, the hospital was further expanded due to high popularity within the area. The hospital was involved in sending medical personnel to the Princess Mother's Volunteer Doctors and psychologists to combat the Communist Insurgency in the 1960s-80s. In the same time, the Japan International Cooperation Agency (JICA) funded an ambulance service for the hospital and helped set up the first trauma registry of the Ministry of Public Health at Khon Kaen.