The population of the region took part in the Uprising of Petar Delyan (1040–1041) and the Uprising of Georgi Voiteh (1072) against Byzantine rule. Kutmichevitsa was retaken by Kaloyan of the Second Bulgarian Empire in 1203. During that time Devol was once again administrative center of a "hora" (an administrative division of the Second Empire). In the turmoil following the death of Ivan Asen II in 1241, the region shared the fate of neighbouring Macedonia and was conquered by the Byzantines. It was finally lost to Bulgaria during the Uprising of Ivaylo.