The last chiefs of this branch were Domhnall O'Keeffe of Dromagh (d. c. 1655), who was prominent in the Catholic Rebellion of the 1640s, and his son Captain Daniel O'Keeffe, who was killed fighting for King James at the Battle of Aughrim in 1691. The family estates were confiscated in 1703, and sold to the Hollow Blades Company.