The 16th Missouri Infantry Regiment (also known as Jackman's Missouri Regiment, Caldwell's Missouri Regiment, and the 7th Missouri Infantry Regiment (Lewis')) was an infantry regiment that served in the Confederate States Army during the American Civil War. The regiment was formed from men recruited by Jeremiah V. Cockrell and Sidney D. Jackman during an expedition into Missouri in August 1862. Although the recruits fought at the Battle of Lone Jack on August 16, they were not officially mustered into Confederate service until August 31. The regiment fought at the Battle of Prairie Grove on December 7. In May 1863, the regiment was designated the 7th Missouri Infantry Regiment, although this designation was changed to the 16th Missouri Infantry Regiment in December. On July 4, the regiment fought at the Battle of Helena, suffering heavy casualties. The unit then spent time building fortifications at Little Rock, Arkansas, before leaving the town in September. The 16th Missouri then fought at the Battle of Pleasant Hill on April 9, 1864, and at the Battle of Jenkins' Ferry on April 30. On June 8, 1865, the men of the regiment were paroled and sent back to Missouri via steamboat. More men died while serving in the 16th Missouri Infantry Regiment than died in any other Missouri unit serving in the Confederate States Army.