After earning his spot through sectional qualifying, Thompson led after the first round of the 2012 U.S. Open after shooting a four-under par round of 66, which included seven birdies, to lead by three strokes. This was the low round of the week. He followed this up with rounds of 75–74 to enter the final round six back of the leaders. Thompson then completed a three-under par round of 67 to hold the clubhouse lead at +2, until Webb Simpson bettered it by a stroke. Thompson finished tied for second with Graeme McDowell to record his best finish in a major championship. Thompson moved up over 50 places in the Official World Golf Ranking (OWGR) to 52nd with this finish.