Lewis has been engaged in domestic U.S. political campaigns. Lewis was a member of the National Finance Committee for Hillary Clinton's 2008 presidential campaign, a role she held again in the 2016 presidential election cycle. She was a pledged delegate for Hillary Clinton from the District of Columbia during the 2016 Democratic National Convention in Philadelphia. She is a past member of a DNC platform standing committee and currently is an elected D.C. Democratic State Committee At-Large Committeewoman.