On 18 August 2017, Guzmán scored his first goal and brace of the 2017–18 season against Morelia resulting in a 2–1 victory. Four days later, he would score another brace and contribute one assist in a 4–1 victory over Veracruz. He scored another brace the following month in a 4–0 win over Cruz Azul. He ended the Apertura 2017 as the highest scoring Mexican goalscorer with eight goals, and was included in the Best XI of the Apertura. On 9 December, in the FIFA Club World Cup quarter-final match against Wydad Casablanca, Guzmán scored the winning goal in extra-time.