From São Leopoldo and Novo Hamburgo, the German immigrants spread into others areas of Rio Grande do Sul, mainly close to sources of rivers. The whole region of Vale dos Sinos was populated by Germans. During the 1830s and part of the 1840s German immigration to Brazil was interrupted due to conflicts in the country (Ragamuffin War). The immigration restarted after 1845 with the creation of new colonies. The most important ones were Blumenau, in 1850, and Joinville in 1851, both in Santa Catarina state; these attracted thousands of German immigrants to the region.