Hamparian founded and directed the Nayiri Dance Group of New York in 1963, which specialized in Armenian folk dances, but also performed original works by Hamparian. Her children were members of the group, as was her sister-in-law, Alice Aghavni Kasbarian. The group performed at the World's Fair in New York in 1964 and 1965; later they also performed at Carnegie Hall, the Democratic National Convention, and the American Bicentennial festival at Rockefeller Center. She was a member of the Armenian Folk Dance Society of New York.