Friant commanded the 2nd Brigade (61e and 88e Ligne) of General Desaix's division in Egypt, taking part in the Battle of the Pyramids (21 July 1798), and in Desaix's brilliant campaign in Upper Egypt. He was provisionally promoted to Général de Division on 4 September 1799, and succeeded Desaix as commander in Upper Egypt after Desaix departed to play his decisive but fatal part in the Marengo campaign. Friant took a lead role in the suppression of the great revolt in Cairo in March–April 1800. Confirmed in the rank of Général de Division and named Governor of Alexandria in September 1800, he fought the British at the Second Battle of Aboukir (8 March 1801), and defended Alexandria through August 1801.