In Peru's second game of the 2019 Copa América, Farfán scored a goal in Peru's 3-1 victory over Bolivia. Farfán suffered an injury to his left knee prior to Peru's last-eight clash against Uruguay, ruling him out of the rest of the tournament. The Peruvian Football Federation (FPF) confirmed the injury, with Farfán expected to be sidelined for 6 to 9 months. On 6 July 2019, Farfán underwent knee surgery in Barcelona, just hours before his team faced hosts Brazil in the 2019 Copa América Final. Peru went on to lose the game 3–1 in his absence.