With the coming of the American Revolution, Loxley was a committed Patriot. One of his first acts was to turn over the city stores he was in charge to the Patriots, who were then labeled "Rebels" by the British. He was elected to the Philadelphia Committee of Safety in 1775. After news was received of the Battles of Lexington and Concord, the Philadelphia Associators was reorganized, with Captain Loxley placed in command of