Hecking became manager of Wolfsburg on 22 December 2012. He made his debut on 19 January 2013 in a 2–0 win against Stuttgart. During the 2012–13 season, Wolfsburg lost to Bayern Munich twice. Wolfsburg lost to Bayern 2–0 in the league on 15 February 2013 and 6–1 in the German Cup on 16 April 2013. Wolfsburg finished in 11th place. Wolfsburg started the 2013–14 season with a 3–1 win against Karlsruher SC. Wolfsburg again got to the semi-finals of the German Cup. This time losing to Borussia Dortmund. Wolfsburg finished the season in fifth place and won a spot in the Europa League. Wolfsburg started the 2014–15 season by knocking out SV Darmstadt 98. The match finished in a 0–0 draw before Wolfsburg defeated Darmstadt in a shootout. Wolfsburg started the league season with a 2–1 loss to Bayern Munich. However, in the reverse fixture, Wolfsburg won 4–1. In March 2015, in the Europa League, in the round of 16, Wolfsburg defeated Inter Milan by a 3–1 score in the first leg and 2–1 in the second leg for a 5–2 aggregate score. Wolfsburg were eliminated by Napoli. Wolfsburg finished the league season in second place, 10 points behind Bayern. The second-place finish qualified Wolfsburg for the Champions League. On 30 May 2015 Wolfsburg defeated Borussia Dortmund 3–1 in the German Cup final. This was Hecking's first major trophy. Wolfsburg started the 2015–16 season by defeating Bayern Munich in a shootout to win German Super Cup. In Champions League, Wolfsburg won Group B, finishing two points above PSV Eindhoven. Wolfsburg were eventually eliminated by Real Madrid in the quarter-finals. Wolfsburg finished the league season in eighth place. Wolfsburg sacked Hecking on 17 October 2016. Hecking's final match was a 1–0 loss to RB Leipzig. Wolfsburg were in 14th place when Wolfsburg sacked Hecking. Hecking finished with a record of 81 wins, 41 draws, and 43 losses in 165 matches.