Clemente Biondetti participated in one Formula One World Championship event, the 1950 Italian Grand Prix. Driving a self-built Ferrari-Jaguar hybrid car, engine problems forced him out of the race thus he failed to score any championship points. Biondetti loved racing cars and continued to compete in sports car and endurance events, earning a second-place finish in a Ferrari at the 12 Hours of Pescara in 1952 against much younger drivers. After suffering from cancer for a number of years, he was forced to retire in 1954. He succumbed to cancer on 24 February 1955 in Florence. As a result, he became the first Formula One World Championship driver to die of natural causes.