Vizziello moved up to the Superbike World Championship for 2005, riding a Yamaha YZF-R1 for the Italia Lorenzini by Leoni team. Vizziello endured a difficult rookie season as he only scored points three times with a best finish of 10th at Imola. He finished 28th in the championship with 9 points. Vizziello made a surprise return to the Superbike World Championship midway through the 2015 season, riding a Kawasaki ZX-10R for the Grillini SBK Team for the remainder of the season. He scored 13 points with a best finish of eleventh at Magny-Cours. Vizziello substituted for Román Ramos at the 2016 rounds of Imola and Sepang after Ramos got injured in second free practice at Imola. Later that season Vizziello rejoined the Grillini Racing Team for the remainder of the season.