Completed on 31 October 1942, "Agano" participated in the battles for Guadalcanal and the Solomon Islands during 1943. "Agano" was badly damaged in Rabaul harbor by aircraft from the aircraft carriers and , and in a subsequent attack by aircraft from TF38 on 11 November she received a torpedo hit. Ordered to home waters for repair, she was torpedoed and sunk north of Truk by the US submarine , on 16 February 1944.