Pellerano Alfau served as editor and publisher of the newspaper until his death in the early 1930s. During his tenure, "Listín Diario" championed some of the era's more significant regional issues, such as: Cuban Independence, from 1894-98, during which time it regularly published letters from Dominican General Máximo Gómez, who fought on the Cuban side; during the American intervention of 1916-24, Listín maintained a serene opposition to the intervention, regularly publishing articles and editorial columns written by the Dominican patriots. Listín's biggest battle of the first half of the twentieth century was against General Rafael Leónidas Trujillo, whom it opposed during the first ten years of his mandate, and as a consequence, was financially strangled by the dictator, having to shut down operations for all of 21 years.