From 12 March 2014 to 29 November 2015, Tlaltenco was closed due to technical and structural faults in the stretch Atlalilco–Tláhuac. On 28 August 2017, a passenger jumped to the tracks and survived. He was in a state of intoxication and was fined $400,000 pesos. After the 19 September 2017 earthquake damaged Line 12 tracks, Tlaltenco remained closed until 30 October 2017. The earthquake derailed a train in the Tlaltenco–Zapotitlán overpass. From 23 April to 28 June 2020, the station was temporarily closed due to the COVID-19 pandemic in Mexico. On 3 May 2021, Tlaltenco station was closed after a portion of Line 12's elevated railway collapsed near Olivos station.