Berkman made key contributions in Game 6 of the 2011 World Series vs the Texas Rangers. He hit his first home run in a World Series game in the first inning and in the ninth, with St. Louis down to their final strike before elimination, Berkman was driven home followed by Albert Pujols after a game-tying 2-run triple by David Freese. After Texas scored two runs in the top of the tenth and Ryan Theriot hit a run-scoring groundout, Berkman hit a two-out two-strike RBI single scoring Jon Jay to tie the game. Berkman won his first World Series championship as the Cardinals defeated the Texas Rangers in the series in 7 games.