After her repairs were completed, the ship spent most of 1941 on convoy escort duties before she was transferred to the Far East after the start of the Pacific War in December. "Exeter" was generally assigned to escorting convoys to and from Singapore during the Malayan Campaign, and she continued on those duties in early February 1942 as the Japanese prepared to invade the Dutch East Indies. Later that month, she was assigned to the Striking Force of the joint American-British-Dutch-Australian Command (ABDACOM), and she took on a more active role in the defence of the Dutch East Indies. The culmination of this was her engagement in the Battle of the Java Sea later in the month as the Allies attempted to intercept several Imperial Japanese Navy invasion convoys. "Exeter" was crippled early in the battle, and she did not play much of a role as she withdrew. Two days later, she attempted to escape approaching Japanese forces, but she was intercepted and sunk by Japanese ships at the beginning of March in the Second Battle of the Java Sea.