"Twiggs" joined the Bombardment Group which sortied from Ulithi on 10 February for rehearsals at Loesip Island. On 16 February, the force arrived off Iwo Jima where "Twiggs" quickly began fire support for pre-assault underwater demolition operations off the eastern beaches. She also conducted screening and harassing activities, firing on Japanese shore units and providing illumination. On the 17th, a suicide plane attack on "Twiggs" resulted in a close call when the plane, in an obvious attempt to crash into the destroyer, crossed her fantail before hitting the water off her port beam and sinking without exploding. The destroyer continued activities to support American ground forces during the grueling battle for Iwo Jima. On 10 March, she retired toward the Carolines, arriving at Ulithi two days later for rest and replenishment.