Over the course of nine seasons, Scuderia Centro Sud entered a total of 49 World Championship rounds, with cars such as the Maserati 250F, various Maserati-powered Coopers and, in the 1960s, a BRM P57. After a very promising start (they scored their first points at their debut with Luigi Villoresi), Centro Sud went on to earn a further total of 24 points, mostly with Masten Gregory and Tony Maggs, but never won a race, with Gregory's third place at the 1957 Monaco Grand Prix as the team's best result.