The 4th Texas was at the Battle of South Mountain on 14 September 1862 where it lost six killed and two wounded. At the Battle of Antietam on 17 September the regiment suffered its worst losses of the war, losing 57 killed, 130 wounded, and 23 captured, a total of 210 casualties. Another source listed 11 killed and 110 wounded, a total of 121. The Texas Brigade was led by William T. Wofford since Hood was appointed to lead the division. The 4th Texas participated in a skirmish the evening before Antietam. At 7:00 am the following day, after the initial Union attack broke through the Confederate first line, the 2,300 men of Hood's division charged into the battle. The division consisted of Law's brigade and the Texas Brigade under the command of William T. Wofford. The 5th Texas advanced to the right into the East Wood along with the 4th Alabama. The rest of Hood's division charged into the Miller cornfield, throwing back the Federal units there. The 1st Texas rushed to the northern edge of the cornfield where it confronted a fresh Union battle line and was nearly destroyed. The 4th Texas swung left to defend a fence line against Federals attacking from the west, and also suffered terrible losses. Later, Hood was asked where his division was and he answered, "Dead on the field".