When campaigning for re-election at the 2017 general election, Wollaston promised her constituents, at a hustings, that she would "accept the result" of the 2016 EU referendum, noting that 54% of her constituents had voted to leave. She went on to state that "one of the things that annoys people is telling them that they didn't know what they were voting for", rejecting the idea of holding a second referendum. She was returned with a reduced majority of 13,477, despite gaining 2,031 more votes. She was appointed Chair of the Liaison Committee after the election.