In his 14th NBA season, Conley was named an All-Star for the first time in his career as it was announced that he would be a reserve for the 2021 NBA All-Star Game, replacing the injured Devin Booker. His 14-year wait is the longest ever for a first time All-Star. He recorded three points, one rebound, and two assists in 12 minutes in the game. Conley was also announced as Booker's replacement in the Three-Point Contest, where he competed against teammate Donovan Mitchell. Conley lost in the final round to Stephen Curry, 28–27.