On 9 August 2010, Milito signed a new four-year contract with the "Nerazzurri". On 26 August, at the ceremony called for the delivery of the UEFA Club Football Awards, Milito was voted the best player and striker in the previous season's European club by winning the prestigious UEFA Club Footballer of the Year and UEFA Club Forward of the Year. Inter followed the previous season's success with a victory in the Supercoppa Italiana against Roma. He failed to convert a penalty in the 90th minute, however, in the 2010 UEFA Super Cup match against UEFA Europa League champions Atlético Madrid; the game finished 2–0 for the Spaniards. He played his first match of the league on 30 August 2010 in week one against Bologna, where Inter started the season with a goalless draw. On 14 September, Milito scored an accidental own-goal in first match of group stage in Champions League against Twente. Eight days later, on 22 September, Milito scored his first goals of the season in a 4–0 win against nearly promoted club Bari at San Siro, helping the team to reach in top of the league. After that, he went to wait until 10 November to score his next goal, where he scored against Lecce to put his team ahead in 76th minute, but, however, Lecce would equalizing three minutes later with Uruguay international Rubén Olivera. He dedicated the goal to his teammate Walter Samuel, who three days ago ended his season after suffered a severe knee injury.