On June 21, 2018, the Minnesota Timberwolves drafted Okogie with the 20th overall pick in the 2018 NBA draft. On July 2, 2018, he signed with the Timberwolves. He participated in the 2018 NBA Summer League. After Jimmy Butler was traded from Minnesota in early November, Okogie entered the starting lineup, averaging nearly 22 minutes a game on the season. After the season, he participated in the 2019 NBA Summer League. On January 29, 2019, he was named a member of the World Team for the 2019 Rising Stars Challenge.