Stanisław was born in Krysk near Płońsk. He became Royal chamberlain in 1780, Great Podstoli of the Crown in 1784. He was a strong supporter of reforms in the Republic. He participated in the Great Sejm in 1788–1792 as representative of the Kraków Voivodeship for the second time. He was a member of the "Radziwill Club", which prepared the passing of the Constitution of 3 May 1791 by the Sejm. After the adoption of the Constitution, he became member and co-founder of the Assembly of Friends of the 3 May Constitution. Reportedly, he was the last known inhabitant of the Krzyżtopór castle complex, living there in the years 1782-1787.