Gasly made his Formula One race début at the 2017 Malaysian Grand Prix with Scuderia Toro Rosso, replacing Daniil Kvyat. He finished the Malaysian and Japanese Grands Prix outside the points. Gasly was expected to take Carlos Sainz Jr.'s seat at Austin but he was forced to miss the race due to a clash with the final round of the 2017 Super Formula Championship. He returned to the team for the , partnering with Brendon Hartley after the team decided to drop Kvyat from the Red Bull programme.