It is unknown whether Cambysene was incorporated into the Achaemenid Empire. When the Kingdom of Armenia under the Artaxiad dynasty was at its territorial apex, during the reign of Tigranes II of Armenia (95–55 BC), Cambysene was one of its provinces or districts. Cambysene remained part of Armenia until it was conquered by Caucasian Albania, most likely after Tigranes was defeated in 69 BC by the Romans at the Battle of Tigranocerta.