Neuner started biathlon when she was nine years old and won five junior world championship titles from 2004 to 2006. She made her World Cup debut in 2006 and won her first World Cup race in January 2007. One month later, she claimed three gold medals in her first appearance at the Biathlon World Championships. In the 2007–08 season, Neuner won the Overall World Cup and once more claimed three titles at the 2008 World Championships. After a less successful winter in 2008–09, she participated in her first Winter Olympic Games in 2010, winning the gold medal in both the pursuit and the mass start, and silver in the sprint race. Neuner also claimed the 2009–10 Overall World Cup title. At the 2011 World Championships, she won three more gold medals. In her final winter on the World Cup tour, Neuner won two more titles at the 2012 World Championships and claimed the Overall World Cup for a third time.