Duhamel was the official pace car driver for the 2009 Indianapolis 500, driving the 2010 Chevrolet Camaro Pace Car. In 2010, he played the lead role in the film "When in Rome" as Nick Beamon. In 2014 Duhamel starred in the touching drama "You're Not You" (2014) playing the husband of Kate (Hilary Swank), who has the degenerative disease ALS.