In the 2005 World Series of Poker (WSOP), Mizrachi tied the record of seven money finishes in a single year. In the 2008 World Series of Poker, he finished third in the $10,000 Pot-Limit Omaha World Championship. In 2010, Mizrachi won his first bracelet in The Poker Player's Championship, defeating Vladimir Shchemelev heads-up and winning $1,559,046. His brother Robert Mizrachi finished 5th in the same event. Later that year, Mizrachi also made the November Nine in the Main Event. He would go on to finish 5th, earning $2,332,992, and was eliminated by eventual winner Jonathan Duhamel. Despite his strong performance at the 2010 WSOP, Frank Kassela was awarded the Player of the Year award based on the pre-existing scoring system. This was controversial because some felt that Mizrachi's year was better, which resulted in a refinement of the scoring system. Mizrachi's success in 2010 led to ESPN poker announcer Norman Chad labelling it "The Year of The Grinder".