Nishimura was preselected as a referee for the 2010 FIFA World Cup. He was the referee for the Uruguay against France game at the 2010 FIFA World Cup, along with fourth official Joel Aguilar and assistant referees Jeong Hae-Sang, and Toru Sagara. Nishimura produced the first red card of the tournament, when he sent Uruguay midfielder Nicolás Lodeiro off the field for two yellow cards. During the first quarter-final game between Brazil and the Netherlands at Nelson Mandela Bay Stadium in Port Elizabeth, Nishimura sent off Felipe Melo of Brazil in the 73rd minute of the game. He was the 4th official for the final match of the World Cup, Netherlands vs. Spain.