Scherff made his professional debut in the Redskins' season-opening 17-10 loss to the Miami Dolphins. He started all 16 regular season games, played 752 snaps, and helped the Redskins finish first in the NFC East with a 9-7 record. In January 2016, he started his first career postseason game, as the Redskins were routed by the Green Bay Packers in the NFC Wildcard game 35-18. Scherff finished his second season starting in all 16 regular season games, and due to his highly regarded performance that year, he was voted to the 2017 Pro Bowl, his first such vote. He was also voted to the 2018 Pro Bowl the following year.