Large married the former Josephine Ramsey on November 15, 1877, and she died not long before their sixtieth anniversary, on January 5, 1937. They had three children: George Knowles (born February 3, 1879), Edwin Kirk (born August 14, 1880), and Helen Brokaw (born August 12, 1889). George K. Large served as judge of the Hunterdon County Court of Common Pleas and was an assistant prosecutor in the Lindbergh kidnapping trial. Edwin K. Large served as postmaster of Atlanta, Georgia.