The former chapel of the Middlesex Hospital by John Loughborough Pearson is now the only surviving building of the Hospital. The chapel was completed after the architect's death under the supervision of his son, Frank, also an architect. The chapel was structurally complete by the mid-1920s; the surrounding hospital was then demolished and rebuilt around it between 1928 and 1929. The chapel was not formally opened until 1929, by which time much of the lavish interior decoration of marbles and mosaic in a mix of Italian gothic and romanesque styles had been added, giving it the appearance it broadly retains today. The chapel is a Grade II* Listed building.