In April 1536 the Spanish conquistador Gonzalo Jiménez de Quesada led the main expedition into the heart of the Andes, where the Muisca Confederation was located, with around 800 Spanish soldiers and 85 horses. Around the settlements of Suesca and Nemocón the de Quesada expedition faced the first attempt of Muisca active resistance in March 1537: the Muisca "zipa" Tisquesusa made a failed effort to oust the invaders who then gave the first demonstration of their superior weaponry.