In 1513, during the War of the League of Cambrai, he had to accept the role of quartermaster-general for the army, which had closed ranks near Vicenza. Andrea Loredan died in the Battle of La Motta in that same year, beheaded by two soldiers who fought over his body. In 1581, his heirs obtained permission from the Council of Ten to sell off the Palace to the Duke of Brunswick for fifty thousand ducats.