The 17th century in central and parts of eastern Europe was a period of general decline; the region experienced more than 150 famines in a 200-year period between 1501 and 1700. From the Union of Krewo (1385) east-central Europe was dominated by the Kingdom of Poland and the Grand Duchy of Lithuania. The hegemony of the vast Polish–Lithuanian Commonwealth had ended with the devastation brought by the Second Northern War (Deluge) and subsequent conflicts; the state itself was partitioned and ceased to exist at the end of the 18th century.