The Rays went up 1–0 in the second on rookie Evan Longoria's leadoff home run in his first postseason at-bat off of Javier Vazquez, but starter James Shields allowed consecutive leadoff singles in the third before DeWayne Wise's two-out three-run home run put the White Sox up 3−1. In the bottom of the inning, however, Jason Bartlett hit a leadoff single and scored on Akinori Iwamura's triple. After B. J. Upton struck out, Willy Aybar's sacrifice fly tied the game before Longoria's home run put Tampa up 4–3. The Rays added to their lead on Longoria's one-out single with two on off of Vazquez, who was then relieved by Clayton Richard and allowed an RBI single to Carl Crawford. Paul Konerko's leadoff home run in the ninth off of Dan Wheeler made it 6–4 Tampa, but Wheeler retired the next three batters to end the game and give the Rays a 1–0 series lead as they won their first postseason game in franchise history. Longoria became only the second ever player to homer in his first two career post-season at-bats, the other being Gary Gaetti in 1987.