It was one of three state volunteer regiments that fought in the Santiago Campaign in Cuba, and the only volunteer unit at the Battle of El Caney. The regiment participated in the Siege of Santiago until the city surrendered, spent several weeks in Cuba, and was moved back to the United States as a result of disease in August. After the end of a quarantine period the regiment was placed on leave and mustered out at the end of the period of leave in early November.