On 10 June 2016, Vidal produced a man of the match performance, scoring both goals in a 2–1 win over Bolivia in Chile's second group match of the Copa América Centenario. He provided two assists in Chile's 7–0 victory over Mexico in the quarter-final on 18 June, but also received his second booking of the tournament for a foul on Jesús Dueñas in the 38th minute, which ruled him out of the victorious semi-final match against Colombia. In the final of the tournament, a repeat of the previous year's tournament, against Argentina, the match once again went to a penalty shoot-out following a 0–0 deadlock after extra-time. Vidal missed Chile's first penalty, but his nation won the shoot-out 4–2 to defend the title. Vidal was once again named to the Team of the Tournament for his performances.