Pedroia was hitless through the first three games of the 2008 ALDS, recording only an RBI double in Game 4. The Red Sox defeated the Angels in four games. In the ALCS against the Tampa Bay Rays, Pedroia collected nine hits in 26 plate appearances, including three home runs and a double. The rest of the team struggled to a .234 batting average against the Tampa pitching staff, and the Red Sox lost the series.