Betts was selected to the 2016 MLB All-Star Game, the first of his career. He started in right field and was 1-for-2 with a single, and a RBI. Betts was named the AL Player of the Month for July, when he batted .368 (35-for-95) with five home runs, 15 RBIs, five stolen bases and a 1.068 OPS in 23 games. On September 20, Betts became the first player to reach 200 hits during the 2016 MLB season. In 158 games played, Betts finished the season with a .318 batting average, 214 hits, 122 runs scored, 42 doubles, 31 home runs, 113 RBI, and an MLB-leading 359 total bases. His 67 multi-hit games also led MLB. He also was 2nd in the league in power-speed number (28.3).