The 5th Missouri Infantry Regiment was an infantry regiment that served in the Confederate States Army during the American Civil War. The regiment entered into service on September 1, 1862, when the elements of two preceding battalions were combined. Many of the men entering the regiment had seen service with the secessionist Missouri State Guard. James McCown was the regiment's first colonel. After playing a minor role at the Battle of Iuka on September 19th, the regiment then fought in the Second Battle of Corinth on October 3rd and 4th. After being only lightly engaged on the 3rd, the regiment charged the Union lines on the 4th, capturing a fortification known as Battery Powell. However, Union reinforcements counterattacked and drove the regiment from the field. In early 1863, the regiment was transferred to Grand Gulf, Mississippi, where it built fortifications. The unit spent part of April operating in Louisiana, before again crossing the Mississippi River to return to Grand Gulf.