The film charts the meeting, courtship and marriage of Julie Gardiner (Irene Dunne) and Roger Adams (Cary Grant) through the playing of popular songs relevant to each time period. After their spur-of-the-moment marriage on New Year's Eve and a night in Roger's train compartment en route to San Francisco, a pregnant Julie rejoins Roger in Tokyo, where he has a stint as a reporter. Julie loses their unborn child in the 1923 Tokyo earthquake and returns with Roger to California despondent, until their friend Applejack Carney (Edgar Buchanan) encourages them to adopt a child. While Roger struggles to keep a newspaper going in the fictional California town of Rosalia, Julie keeps house and fits out the nursery.