The Solitude of Prime Numbers () is a 2010 Italian drama film based on the novel of the same name by Paolo Giordano. Directed by Saverio Costanzo, the film was nominated for the Golden Lion at the 67th Venice International Film Festival. The soundtrack was composed by Mike Patton and released in 2011. The title is explained by arguing that Mattia and Alice are like twin primes: both lonely, close to each other but separated by an even number.