William Holburne took command of the 80-gun , which formed part of the expedition to Louisbourg under his brother in 1757. He went to the Mediterranean in 1759, and served as part of Admiral Sir Edward Boscawen's fleet at the Battle of Lagos. During the battle Boscawen's flagship, was badly damaged and un-manoeuvrable. Boscawen therefore shifted his flag to Holburne's "Newark". Holburne did not command any more ships after "Newark", and died on 1 April 1760.