He reduced mortality from tuberculosis in Romania and played a leading role in the development of a national strategy involving the research, prophylaxis and treatment of tuberculosis, as well as the establishment of a network of sanatoria and clinics for the treatment of pulmonary diseases in Romania. Nasta laid the foundations for the teaching of modern epidemiology of tuberculosis, set up the first Chair of Phthisiology at the Bucharest Faculty of Medicine and fostered research in the field of bacteriology. He founded and directed a leading hospital and research center in the field of respiratory medicine called "Institutul de Ftiziologie". In 1959, his career was cut short by the communist regime that "exposed" him for his "cosmopolitan behavior". After the fall of communism in Romania in 1989, his contributions to the scientific, medical and academic field were once again recognised and the institute was renamed "Institutul de Pneumoftiziologie Marius Nasta" in his honour. He is regarded as "one of the fathers of the care, treatment, and study of tuberculosis of the lung in Romania".