"Mystery of Love" was nominated for awards at several ceremonies, including the Critics' Choice Movie Awards, Georgia Film Critics Association, and Guild of Music Supervisors Awards. It was also nominated by the Academy of Motion Picture Arts and Sciences for the Academy Award for Best Original Song. The song also received a nomination for the Grammy Award for Best Song Written for Visual Media at the 61st ceremony. Commercially, "Mystery of Love" entered "Billboard"s Hot Rock Songs chart in the United States and reached the main record charts in France, Hungary, Portugal, and Scotland.