In 2016, the Libertarian Party's nominee for president was Gary Johnson, who promoted Bill Weld to be the vice presidential nominee. Harlos opposed Weld, arguing for a member of the Radical Caucus to be on the ticket to balance with some of Johnson's views that did not conform to typical Libertarian positions. At the 2016 Libertarian National Convention, she made a nominating speech for vice presidential candidate Will Coley, who lost to Weld.