The first hospital was founded in the town by Bishop Fray Pedro de Silva in 1485. Those affected by the plague epidemic were treated here in 1506. During the 16th century the city experienced a cultural renaissance thanks to personalities such as the painter Luis de Morales, the composer Juan Vázquez, the humanist Rodrigo Dosma, the poet Joaquin Romero de Cepeda, the playwright Diego Sánchez de Badajoz, the Dominican mystic Fray Luis de Granada and architect Gaspar Méndez. In 1524, a board meeting between representatives of Spain and Portugal took place in the Old Town Hall in the city to clarify the status of their territorial arrangements, attended by Hernando Colón, Juan Vespucio, Sebastián Caboto, Juan Sebastián Elcano, Diego Ribeiro and Esteban Gómez. With reason to assert their rights to the Portuguese Crown, Philip II of Spain briefly moved his court to Badajoz in August 1580. Queen Anne of Austria died in the city two months later, and on 5 December 1580, Philip moved out of the city. From 1580 until 1640, as a result of the absence of war, the city flourished once again. According to the historian Vicente Navarro del Castillo, some 428 residents of Badajoz contributed to the Spanish conquest of the Americas, including Pedro de Alvarado, Luis de Moscoso, Sebastián Garcilaso de la Vega y Vargas (father of Inca Garcilaso) and Hernán Sánchez de Badajoz. In 1640 the city was attacked during the Portuguese Restoration War.