He entered Formula One in 1959, although only with sporadic appearances at first. He drove various cars under the banner of the ENB team, including a Cooper T51, a Lotus 18 and an Emeryson. After a couple of races for the UDT Laystall team in 1961, driving another Lotus, he returned to ENB for whom he drove their ENB-Maserati. He finally secured a more regular drive in Formula One in 1968, with the Cooper-BRM team, although success was elusive despite a bright start. Bianchi managed his best Formula One performance, finishing third at the 1968 Monaco Grand Prix, in his first race for Cooper.