Vujačić was drafted by the Los Angeles Lakers with the 27th overall pick in the 2004 NBA draft. He signed a multi-year deal with the Lakers on July 20, 2004. He recorded a then-career high 22 points in a win over the Denver Nuggets on November 29, 2007. In the 2007–08 season, Vujačić made 118 of his 270 three-point field goal attempts, setting the Los Angeles Lakers single-season record for the best three-point field goal percentage (.437). During Game 3 of the 2008 NBA Finals, Vujačić scored a career playoff-high 20 points off the bench and was the only Laker, with the exception of Kobe Bryant, to score in double figures. The Lakers went on to lose the series in six games to the Boston Celtics.