Quigley played for DePaul University in Chicago. After graduating in 2008, Quigley was drafted by Seattle Storm with the 22nd overall pick in the 2008 WNBA Draft. After five years playing for four teams in the WNBA, Quigley returned to Chicago as a member of the Chicago Sky in 2013. Quigley was voted winner of the WNBA Sixth Woman of the Year Award for 2014 after helping the Sky reach the WNBA Finals for the first time, and won the award again in 2015. She was named a WNBA All-Star in 2017, 2018, and 2019. She won the All-Star Weekend Three-Point Contest in 2017, 2018, and 2021.