De Rossi made his professional debut with Roma during the 2001–02 season, and made his Serie A debut the following year. With the club, he won the Coppa Italia twice in 2007 and 2008, and the 2007 Supercoppa Italiana. He was named Serie A Young Footballer of the Year in 2006, and the Serie A Italian Footballer of the Year in 2009. De Rossi inherited the captaincy of Roma at the start of the 2017–18 season, following the retirement of Francesco Totti, during which he helped Roma to the Champions League semi-final for the first time in the Champions League era. At the end of the 2018–19 season, he left Roma after 18 seasons with the team. With 616 appearances for Roma in all competitions, he is the club's second-most capped player of all time, behind Totti. He subsequently joined Argentine club Boca Juniors in the summer of 2019, and retired from professional football in January of the following year.