The Fatimids again lost the region to the Crusaders in 1099. The Crusaders set up the Kingdom of Jerusalem (1099–1291). Their control of Jerusalem and most of Palestine lasted almost a century until their defeat by Saladin's forces in 1187, after which most of Palestine was controlled by the Ayyubids, except for the years 1229–1244 when Jerusalem and other areas were retaken by the Second Kingdom of Jerusalem, by then ruled from Acre (1191–1291), but, despite seven further crusades, the Franks were no longer a significant power in the region. The Fourth Crusade, which did not reach Palestine, led directly to the decline of the Byzantine Empire, dramatically reducing Christian influence throughout the region.