Kalil was born Ryan Joseph Kalil in 1985 to Frank and Cheryl Kalil. His father, Frank, played football for the University of Arkansas and the University of Arizona. He was drafted by the National Football League Buffalo Bills in 1982 and later played in the United States Football League until 1984. His mother, Cheryl (Van Cleave), was Miss California in 1981. He is of Lebanese and Mexican heritage and has two siblings. His brother, Matt, is a former starting offensive tackle at USC and was drafted fourth overall by the Minnesota Vikings in 2012. They were the third set of brothers to play on the same offensive line in the NFL when Matt joined Ryan on the Panthers in 2017 and the first set of brothers to do it in 24 years. Their sister Danielle sang the national anthem at the Vikings–Panthers game, which featured both her brothers, on October 13, 2013.