The winner of the previous edition, Fausto Coppi, did not defend his title, apparently due to injury. The reasons were not clear: it could have been injury, but it was also possible that Coppi did not want to ride in the same team as his rival Gino Bartali, or that the Tour direction urged the Italian team not to select Coppi because he had dominated the 1952 Tour, or that Coppi chose to prepare for the 1953 UCI Road World Championships. The big favourites became Hugo Koblet and Louison Bobet.