The Ruthven family descended from Sir William Ruthven, who was created Lord Ruthven in the Peerage of Scotland in 1488. Lord Ruthven's son and heir, William Ruthven, Master of Ruthven, was one of the many Scottish nobles killed at the Battle of Flodden in 1513. Lord Ruthven died in 1528 and was succeeded by his grandson, William, the second Lord, the son of the Master of Ruthven. The second Lord was an Extraordinary Lord of Session and Keeper of the Privy Seal of Scotland. He was succeeded by his son, Patrick, the third Lord. Patrick was the leader of the band which murdered David Rizzio. After the murder he fled to England where he died in 1566. He was succeeded by his son, William, the aforementioned fourth Lord, who was created Earl of Gowrie in 1581 (see above).