In 1910 Perkins achieved statewide prominence as head of the New York office of the National Consumers League and lobbied with vigor for better working hours and conditions. She also taught as a professor of sociology at Adelphi College. The next year, she witnessed the tragic Triangle Shirtwaist Factory fire, a pivotal event in her life. The factory employed hundreds of workers, mostly young women, but lacked fire escapes. When the building caught fire, many workers tried unsuccessfully to escape through the windows. Just a year before, these same women and girls had fought for and won the 54-hour work week and other benefits that Perkins had championed. One hundred and forty-six workers died. Perkins blamed lax legislation for the loss.