In the 2007–08 season, Meghni joined Lazio on a co-ownership deal for €1.75 million fee. His early performances for the Biancocelesti were not impressive, and he failed to nail down a regular place in the line-up, only starting seven matches for the season. He did make his debut in the UEFA Champions League, setting up a crucial goal for Tommaso Rocchi, which gave the club their only win in the competition, at home to Werder Bremen. In June 2008 the co-ownership was renewed, but in July, Meghni was fully bought by Lazio from Bologna for another €1.75 million. (as part of the deal of Gaby Mudingayi) After the arrival of Matuzalém, and due to many injury's, Meghni became a backup player, and in December 2009 injured. His contract with Lazio was mutually terminated on 10 June 2011.