She was appointed matron of the 18th Army Corps hospital in September 1864. Her duties included supervising other nurses, and cooking for the hospital patients, often numbering in the thousands. Marston said of her: "Miss Dame was the bravest woman I ever knew. I have seen her face a cannon battery without flinching while a man took refuge behind her for safety from flying shells. She was always present when most needed." She saw action at first Bull Run, second Bull Run, Fredericksburg, and Gettysburg. Dame's tending to the men went beyond medical attention; she would sometimes pick strawberries for the wounded, or write letters home for them. Dame's nursing duties varied as well; sometimes she would oversee supplies, other times she would investigate the sanitary conditions of other regiments. Dame remained at this hospital until the end of active war operations, when she reconvened with the 2nd New Hampshire Regiment. On December 25, 1865, the regiment was mustered out of service, ending Dame's service.