Guerreiro was selected by the main squad for their Euro 2016 campaign, playing the full 90 minutes in the first game, a 1–1 draw with Iceland in Saint-Étienne. Portugal went on to win the competition, defeating hosts France 1–0 in the final in extra time; following his performances throughout the competition, he was nominated for the Young Player of the Tournament Award, which ultimately went to his teammate Renato Sanches.