Following Brissett's freshman season, there was speculation that he could test the waters in the 2018 NBA Draft. However, he announced his intention to return to Syracuse for his sophomore season on April 11, 2018. As a sophomore, Brissett averaged 12.4 points and 7.5 rebounds per game. After the season, he declared his eligibility for the NBA Draft and forfeited his remaining two years of collegiate eligibility. However, Brissett was not drafted.