In June 2021, he was included in Italy's squad for UEFA Euro 2020 by manager Roberto Mancini. On 6 July, following a 1–1 draw after extra-time against Spain in the semi-final of the competition, Jorginho scored the decisive penalty kick in the resulting shoot-out to send Italy to the final; during the match, he completed a tournament high of eight interceptions. In the final on 11 July against England at Wembley Stadium, after a 1–1 draw following extra time, his spot-kick was saved in the penalty shootout by Jordan Pickford, but Italy would go on to win 3–2 in the shootout. Throughout the tournament, he covered the most ground of any player (86.6 km in total), made the most recoveries alongside Manuel Akanji (46), and completed the second most passes of any player after Aymeric Laporte (497 out of 529 attempted, with a 93% passing accuracy); he also won the most fouls (19) and made the most interceptions (25) of any other player, breaking Marcel Desailly's record of 24 interceptions in a single tournament from UEFA Euro 1996, since these statistics first began to be recorded at UEFA Euro 1980. For his performances, he was included in the "team of the tournament".