In 1510, in the midst of the Italian Wars, Pope Julius II wanted to eliminate France's presence in Northern Italy. In order to accomplish this, the Pope dissolved the League of Cambrai, originally established in 1508 as an anti-Venetian alliance between France and the Papal States. In place of the League of Cambrai, the Pope established the Holy League, forming an alliance between the Papal States and Venice. The exclusion of France from the Holy League caused tension to escalate between Julius II and Louis XII. After the Papal States lost Bologna to France, Julius II agreed to negotiate with Louis XII. Negotiations were held between Bishop Andrew Forman and others, including Felice's husband, Gian Giordano Orsini. Julius II sent Felice to accompany Gian Giordano to France in July 1511 where she was involved in negotiations with Queen Anne of Brittany for two years.