In June 1943 "Faulknor" rejoined the 8th Destroyer Flotilla for Fleet duties in the Mediterranean, arriving at Alexandria on 5 July to support the Allied invasion of Sicily (Operation Husky). She served as part of the screen for the covering force in the Ionian Sea (two aircraft carriers, three battleships, and four cruisers with 17 other Allied destroyers). After screening and patrol duties in August, she supported Allied landings on the Italian mainland (Operation Baytown) and at Salerno (Operation Avalanche) with destroyers of 4th, 8th and 24th Flotillas. She was then detached with other destroyers to screen ships escorting the Italian Fleet to Alexandria via Malta, and then was transferred to the Eastern Mediterranean to support Allied operations in defence of Aegean Islands against German invasion. She transported troops to Leros, carried out patrols, sank several cargo ships and landing craft, and carried out bombardments of shore positions before the operation was abandoned in November.