Blind rose through the youth ranks at Ajax, becoming a regular after a loan to Groningen, and won four consecutive Eredivisie titles with the club. In September 2014, he transferred to Manchester United for £13.8 million, where he was part of the team that won four trophies including the FA Cup, EFL Cup and UEFA Europa League. In the summer of 2018, Blind returned to Ajax where he won his fifth Eredivisie title and first-ever KNVB Cup in his first season back at the club.