In the 2010 NLDS, Oswalt pitched Game 2 of the Phillies' three-game sweep of the Cincinnati Reds; he gave up 4 runs in 5 innings, but the Phillies came back to win 7–4. In the 2010 NLCS against the San Francisco Giants, Oswalt won Game 2 by allowing only 1 run in 8 innings, which was his ninth postseason start without a loss. Oswalt entered Game 4 in the bottom of the ninth inning, attempting to preserve a tie game, but took the loss. In Game 6, Oswalt allowed 2 runs in 6 innings but left with the game tied; the Giants later broke the tie to win that game and the series.