In the 1950 World Cup he helped Brazil to progress to the final, but their surprise 2–1 defeat to Uruguay tarnished his reputation. Zizinho played a total of 53 times for his national team, scoring 30 goals. He turned down last minute invitations by the CBF to join first the 1954 World Cup Squad and then the 1958 squad, citing on both occasions that it would be unfair on the player being dropped at the last minute to make way for him.