Gameiro scored a goal in either half against Espanyol on 6 April, helping his side record a 4–1 league victory. On 10 April 2014, Gameiro came off the bench and scored Sevilla's fourth and final goal in a Europa League quarter-final second-leg match, securing a 4–2 aggregate victory over Porto and a spot in the semi-finals of the 2013–14 Europa League. In the 2013–14 La Liga Seville derby against Real Betis three days later, Gameiro scored twice more to give Sevilla a 2–0 away victory. In the final of the 2013–14 Europa League against Portuguese side Benfica on 14 May 2014, Gameiro came off the bench in extra time and scored the game-winning penalty kick to secure a 4–2 shoot-out victory for Sevilla.