Bruno started his career with his home-town side U.S. Lecce in 1979. The defender moved north to Como in 1983, and then four years later joined Juventus in 1987. Although his time with the "Bianconeri" was predominantly disappointing, due to the club's crisis following the retirement of legend Michel Platini, he won a UEFA Cup medal during the 1989–90 season, under manager Dino Zoff, as Juventus defeated Italian rivals Fiorentina in the 1990 UEFA Cup Final, and a Coppa Italia winners medal the same season, defeating Milan in the final. Although Bruno often declared that he had not formed friendships with footballers, partially due to his combative style of play and aggressive behaviour, he notably formed a close friendship with team-mate Ian Rush during his time at the club.