In the general elections of October 2019, Rodríguez stood as a candidate for senator for Cochabamba as a member of the Movement for Socialism party. His broad appeal and frequent presence next to Morales led him to be seen by many as a possible successor to the president. Rodríguez often appeared in public events next to the president and even hosted the inauguration of Morales' 2019 presidential campaign in Chimore on 18 May. Disputes surrounding the 2019 elections ultimately caused the resignation of Morales and the annulment of the results.