Pope Clement VII elected him archbishop of Florence on 11 January 1524. He resigned from that position on 11 October 1532. He served also as administrator of Vicenza from 14 March 1524 until his death, administrator of Forli (16 April 1526 - 7 August 1528). During the Sack of Rome (1527) he was taken hostage to Hugo of Moncada with other cardinals. Later he was named administrator of Viterbo (16 November 1532 – 6 June 1533), administrator of the metropolitan see of Salerno (7 February 1533 - 19 December 1548) and administrator of Imola (4 August 1533 - 17 May 1546). Pope Clement VII opted him for the deaconry of Santa Maria in Cosmedin on 19 January 1534. He participated in the Papal conclave, 1534.