Chien-Ming Wang was called upon to start Game 4 on three days' rest for the Yankees. Grady Sizemore hit a leadoff home run off Wang, who then allowed a one-out single to Travis Hafner, who moved to second on a groundout and scored on Jhonny Peralta's single. Next inning, the Indians loaded the bases off of Wang with no outs on two singles and a hit-by-pitch. Mike Mussina came on in relief and allowed one run to score on Sizemore's double play and another on Asdrúbal Cabrera's single. Wang was charged with four runs in one inning while Mussina threw solid innings, but in the fourth, allowed Cleveland to load the bases on a double and two walks before Víctor Martínez's two-run single proved to be the difference in the Indians 6–4 win. Though four Yankee relievers held Cleveland scoreless for the rest of the game, Cleveland starter Paul Byrd labored but earned the win with five innings of two-run ball. The only runs came on Yankees Captain Derek Jeter's bases loaded single in the second and Robinson Canó's home run in the sixth. Alex Rodriguez's home run in the seventh off of Rafael Perez cut the Indians lead to 6−3, but Joe Borowski earned the save in the ninth despite allowing a home run to Bobby Abreu. The loss marked the third time in five years (2003, 2004, and 2007) the Yankees were eliminated from a postseason series at home. This was the final postseason game ever played at the old Yankee Stadium and the last game that Joe Torre would manage for the Yankees.