Protestant settlers from Scotland, England, and elsewhere in Ireland, settled in the County in the early 17th century. Many would be killed or forced to flee because of the 1641 Rebellion, during which a number of massacres were committed by the Catholic Gaelic Irish, most notably at Shrule in 1642. A third of the overall population was reported to have perished due to warfare, famine and plague between 1641 and 1653, with several areas remaining disturbed and frequented by Reparees into the 1670s.