In 573, during the Byzantine–Sasanian War of 572–591, Khosrow sent an army under Adarmahan to invade Syria, while he himself, along with Izadgushasp and Fariburz, led an army towards Dara, capturing the city after four months. Adarmahan sacked several cities in Syria, which included Apamea. The Byzantine emperor Justin II reportedly lost his mind after these Byzantine disasters and abdicated. In 579, Khosrow was succeeded by his son Hormizd IV, who later ordered the death of 13,600 nobles and religious members, including Izadgushasp, who was first imprisoned and then executed.