On a miserably cold (51 degrees) and rainy evening, Morgan Ensberg's first-pitch home run off starter Mark Buehrle put the Astros on top in the second inning. The White Sox answered in the bottom of the second with two runs of their own off Andy Pettitte. Lance Berkman drove in three runs in the game, two of them on a go-ahead double in the top of the fifth. In the seventh inning, Dan Wheeler loaded the bases with a double to Juan Uribe, a walk to Tadahito Iguchi, and home plate umpire Jeff Nelson's ruling that Jermaine Dye was hit by a pitched ball. The ruling was considered questionable, as television replays showed that the ball hit Dye's bat (which would have made the pitch a foul ball rather than a HBP). The Astros brought in Chad Qualls, who promptly served up a grand slam to Paul Konerko on the very first pitch he threw, the eighteenth grand slam in the annals of the Fall Classic. In the top of the ninth, White Sox closer Bobby Jenks blew the save when he gave up a two-run game-tying pinch hit single to José Vizcaíno. In the bottom half of the ninth, Astros closer Brad Lidge gave up a one-out, walk-off home run — the fourteenth in Series history — to Scott Podsednik, giving Lidge his second loss in as many post-season appearances (his previous appearance was in Game 5 of 2005 National League Championship Series). Podsednik had not hit a single homer in the regular season, and this was his second of the postseason. The Series moved to Houston with the White Sox leading 2-0.