Eustace de Vesci (1169–1216) was an English lord of Alnwick Castle, and a "Magna Carta" surety. He also held lands in Sprouston, Roxburghshire, Scotland as brother in-law to King Alexander II of Scotland. Eustace was a leader during the Barons' War in 1215 and was killed while undertaking a siege of Barnard Castle in 1216.