In January 2016, Sirusho released a new single "Mi Togh Indz Menak" (Do released Leave Me Alone) along with its music video. In August 2016 she performed live at Barclaycard Arena in Hamburg, Germany, and was announced as the Best Armenian Female Act at Daf BAMA Music Awards and performed Qele Qele (Remix version). In the same month Sirusho announced the upcoming release of her new album called "Armat" ("Root") that would represent the Armenian culture. In 2017 Sirusho released a new summer hit song "Vuy Aman" together with Armenian-American singer, songwriter, Sebu Simonian of the Capital Cities band. She performed at the opening ceremony of the 2019 CONIFA European Football Cup in the "de facto" Republic of Artsakh. In 2021, Sirusho released a collaboration single titled "Stay" featuring Norwegian singer Alexander Rybak, who won the 2009 Eurovision Song Contest.