Ghedina was born in Cortina d'Ampezzo in the province of Belluno, and his mother tongue is Ladin. He studied in Innsbruck and made his World Cup debut in 1989. The following year, after a series of initial podiums and a ruinous fall, he won the last two downhills of the season. He won the silver medal in the Combined race of the 1991 World Championships at Saalbach, Austria; however, the following year he suffered a serious car crash.