Targett was only selected for the 4×100-metre freestyle relay alongside countrymen James Magnussen, Eamon Sullivan and James Roberts. As favorites leading up to the London Games, the team was dubbed "Weapons of Mass Destruction" by the Australian media. The morning team, of which Targett and Sullivan were not part of, qualified fastest for the final. In what has been named by some to be "darkest day" in swimming in recent memory, the team came only 4th behind France, the US and Russia. After a slow start by Magnussen, Targett as second swimmer held on to gain a position, while Sullivan, who had the fastest split of the team retained third place, however anchor James Roberts was unable to hold off a Russian powerhouse team, and was pipped at the wall and finished in 4th position.