It was in 1126, after the First Crusade, when a German pilgrim and his wife, whose names are unknown, founded a hospice for pilgrims from the Holy Roman Empire. He joined the Hospice of St. John of Jerusalem. Celestine II sets the rules in 1143, taking the hospital under his protection, but with a right of prior review of the Order of St. John. The building was partly destroyed by the attacks of 1187, and rebuilt in 1229. Frederick II assigned it to the Teutonic Knights in April 1229, but then it went to the Order of St. John by order of Pope Gregory IX. As a result of the capture of Jerusalem in 1244, the hospice and church were left in ruins.