In June 2021, Insigne was included in Italy's squad for UEFA Euro 2020 by manager Roberto Mancini. In the opening match of the tournament on 11 June, he scored Italy's final goal in a 3–0 win over Turkey. On 2 July, he scored Italy's second goal of the match in a 2–1 win over Belgium in the quarter-finals of the competition, with a curling right-footed effort from outside the box following an individual run; for his performance, he was named "star of the match" by UEFA, while the goal later placed second in UEFA's "2020–21 Goal of the Season," behind only Mehdi Taremi's overhead kick goal for Porto against Chelsea in the Champions League quarter-finals. On 11 July, Insigne won the European Championship with Italy following a 3–2 penalty shoot-out victory over England at Wembley Stadium in the final, after a 1–1 draw in extra-time; Insigne started the match, but was replaced by Andrea Belotti late in the second half of regulation time. Throughout the competition, Insigne made more solo runs into the penalty area (16) than any other player.