Taglialatela moved to his native club Napoli in 1990 during their peak, but played in only three games, making his Serie A debut on 6 January 1991, in a 1–0 away defeat to Juventus. After three loan spells at Serie B sides Palermo, Ternana, and Bari, he returned to Napoli, following Giovanni Galli's transfer to Torino, playing with the club from 1993 until 1999. On this occasion, he was finally able to break into the first team, and became the club's number one keeper for several years, as well as the club's captain in 1999, also attracting attention from larger clubs, including Inter, although he elected to remain with Napoli, despite the club's financial crisis. During his third stint with Napoli, he narrowly missed out on the Coppa Italia during the 1996–97 season, as Napoli lost the final to Vicenza. His later seasons with the club were less successful, as Napoli suffered Serie B relegation during the 1997–98 season, conceding numerous goals.