His first senior international medal was a silver at the 2000 African Championships in Athletics. He competed at the 2001 World Championships in Athletics and finished sixth in his first global final. At his first Commonwealth Games, Mulaudzi was first past the finish line to become the 2002 Commonwealth champion in the 800 m. He won a bronze medal at the 2003 World Championships the following year, in addition to a silver medal from the 2003 All-Africa Games.