Wigglesworth started his professional career with Sale Sharks coming through the youth ranks, and starting the 2005–06 Premiership final. In June 2010, Wigglesworth moved to Saracens. During his time at Saracens he won five further Premiership titles in 2011, 2015, 2016, 2018 and 2019, with Wigglesworth featuring in all five finals. He also helped Saracens win the European Champions Cup in 2016, 2017 and 2019. He left Saracens at the conclusion of the 2019–20 season.