With the brigade, the regiment fought in the Siege of Corinth, Mississippi between May 26 and 30, then in the pursuit to Booneville between May 31 and June 12. It marched to Jacinto and Ripley between June 29 and July 4, and remained at Corinth until August 14. On the latter date, it began a march through Alabama to Nashville, Tennessee and Louisville, Kentucky in pursuit of the Confederate Army of Tennessee that lasted until September 26. The regiment became part of the 31st Brigade of the 9th Division of the Army of the Ohio in September, with the division becoming part of the 3rd Army Corps of the army in October. The regiment fought in the pursuit of the Army of Tennessee into Kentucky during the Confederate Heartland Offensive between October 1 and 16, including the Battle of Perryville on October 8 and the action at Stanford on October 14.