After making his debut for the Nigeria national football team against Kenya in May 2002, Enyeama was selected for the 2002 FIFA World Cup as a cover for Ike Shorunmu. He made his competitive debut in that tournament, keeping a clean sheet against England in the third group match. Since the retirement of Shorunmu, he has been the first-choice goalkeeper for the national team, helping the Super Eagles to third-place finishes in the 2004, 2006, 2010 Africa Cup of Nations tournaments, and captaining the team to victory of in the 2013 edition. He has also participated in the 2010 and 2014 FIFA World Cups, and the 2013 FIFA Confederations Cup.