On 3 June 2018, he survived an assassination attempt by the Taliban in Wanna who opened fire on him, killing three supporters of the PTM and injuring dozens others, including Ali Wazir's cousin Arif Wazir. On 16 December 2020, Ali Wazir was arrested by the Sindh Police in Peshawar, where he was present to commemorate the 2014 Peshawar school massacre.