"Frank Knox" again steamed across the Pacific to take part in hostilities in early July 1950, shortly after the outbreak of the Korean War. During this combat tour, which lasted into 1951, her missions included support of the Inchon invasion, shelling enemy targets ashore and patrolling the Taiwan Straits. Two more Korean War cruises followed in 1952 and 1953, and for the rest of the decade "Frank Knox" deployed regularly to WestPac for Seventh Fleet service.