In 1905 she married fellow artist Jean-Jacques Midderigh (1877-1970) with whom she had two children. Midderigh-Bokhorst continued her career, creating illustrations for children's books, magazines, fashion, and advertising. Midderigh-Bokhorst worked through her life, her last book "Glans en gloed uit donkere diepten" was published in 1955. The same year she painted murals for the agricultural school in Zoetermeer . She often collaborated with her husband. In 1910 she was received a gold medal at the Brussels Exposition Universelle et Internationale for book decoration. In 1913 her work was included in the exhibition De Vrouw 1813-1913.