The artillery component never materialized, but the legion was organized in fall 1861 and assigned to Evans' Brigade. William Porcher DuBose, later an Episcopal priest and noted theologian, served as its adjutant until 1862. The legion helped defend Charleston, South Carolina, in the summer of 1862. On July 17, Evans was ordered to move his unit to Richmond, Virginia. After reaching the city, the legion's infantry and cavalry were separated, never to be reunited, a common fate for Civil War legions. The cavalry was assigned to bolster the city's defense and eventually became part of the 7th South Carolina Cavalry Regiment. The Holcombe Legion fought in the Second Battle of Bull Run (or Second Manassas), South Mountain and Antietam (or Sharpsburg), all in August and September 1862. The legion suffered 24 dead and 131 wounded at Second Manassas, and DuBose wrote, "The Holcombe Legion was practically destroyed as a regiment; when we gathered up the remains there were about a hundred men." The legion served as skirmishers for a delaying force at the Battle of South Mountain. In September 1863, it mustered 276 men. It participated in the 1864 Siege of Petersburg and the 1865 Appomattox Campaign which ended in Robert E. Lee's surrender to Ulysses S. Grant, effectively ending the war.