Mei made his debut on the Main Tour in the &lt;a href="2009%E2%80%9310%20snooker%20season"&gt;2009/2010 season&lt;/a&gt;, as the ACBS Asian nomination, playing his first match at the 2009 Grand Prix. He lost 5–0 to Patrick Wallace, and was defeated in his next two matches, in the UK Championship and the Welsh Open, to Atthasit Mahitthi and Stephen Rowlings respectively. Mei recorded his first win as a professional in the 2010 China Open, where he beat Noppadol Sangnil 5–4, having trailed 4–2, but lost in the next round, 5–1 to Robert Milkins. After losing in qualifying for the 2010 World Championship to David Morris, Mei finished the season ranked 89th, and was relegated from the tour thereafter.