With the European Championships cancelled, Trusova instead participated in the 2021 Channel One Trophy, a televised team event. Trusova was elected for the Time of Firsts team captained by Evgenia Medvedeva, and placed fourth in the short program, the only lady on her team to skate cleanly. In the free skate she made errors on both quad Lutz attempts, placing third in that segment, with the team finishing in second place overall.