El-Ghandour has refereed the 2002 African Cup of Nations final (Cameroon vs Senegal), the second leg of the 2002 African Cup Winners' Cup final (Kotoko (Gha) 2:1 WAC (Mar)), and five successive African Cup of Nations, 1994, 1996, 1998, 2000, and 2002. He is the first African referee to run a match in the UEFA European Football Championship. He has also participated in one Olympic Games, one FIFA Confederation Cup (2001), and one AFC Asian Cup.