Sean Safo-Antwi (born 31 October 1990 in London) is a Ghanaian sprinter. He competed for Great Britain before switching allegiance to Ghana in early 2016, a move that was not opposed by the British Federation. He was due to represent Ghana for the first time at the 2016 World Indoor Championships but was withdrawn at the last minute. In 2016 he represented Ghana in the 100 metres at the 2016 Summer Olympics in Rio de Janeiro, Brazil.