In March 2013, Okoye announced his intentions to play in the National Football League, despite having never played American football at school or university; he stated that five NFL teams expressed interest in him, and planned to sign after the 2013 NFL Draft. At the NFL Super Regional Combine, Okoye ran the 40-yard dash in 4.78 seconds, while scoring 36 inches on the vertical jump and 10 feet, 7 inches on the broad jump. Okoye was signed on 27 April by the San Francisco 49ers.