Bishmizzine has a huge historical heritage, starting from the pre-history period. Archaeological evidence covers a period from the Paleolithic/Mesolithic Age to the Bronze Age and Iron Age, up to the late Ancient/Byzantine Age to the Islamic/Middle Age. The name Bishmizzine is thought to be derived from the Aramaic word “"Bit Gismeia"”, which dates back to the Neo-Assyrian Empire (911–609 B.C.). Additionally, one of the several churches of Bishmizzine, "Saydeh" (Virgin Mary), dates back to the Crusader Era (between 1095 and 1291 AD) and contains the typical ecclesiastical characteristics one would see in Crusader architecture. During the Era of the Crusades in the 13th century, Bishmizzine was called "Besmedin". From 1220, it was the seat of an independent rule as a fief of the Count of Tripoli, which was assigned to Lord Bartolomeo Embriaco, a branch of the Lords of Gibelet (modern-day Byblos). The crusaders had developed Besmedin to include a castle or a fortified manor, but no traces of such are preserved today as it is believed they were razed to the ground during the Muslim Mamluk invasion and capture of Tripoli.