Harinordoquy entered the 2005 Six Nations with 30 caps for France. However, he missed the competition's first fixture against Scotland due to a separated shoulder suffered in his last game for Biarritz before the competition. Harinordoquy, subsequently, had difficulty regaining his form immediately after the injury; he was dropped from the squad by the end of the 2005 tournament. He returned to the team ahead of the 2007 Rugby World Cup and quickly cemented his place within the team. Harinordoquy started in France's opening match against Argentina.