After Nagayoshi's death, Sen married one of the three main members of the Toyotomi government, daimyo Nakamura Kazuuji, who was born in Nakamura-ku, Nagoya. During her marriage, Sen gave birth to two children. Her most notable son was Nakamura Kazutada, the first lord who ruled the Yonago Domain. Kazutada married Ieyasu's adopted daughter, further strengthening the relations between the Ikeda clan and the Tokugawa clan even more. Sen's husband, Nakamura Kazuuji, died in August 1600, just before the Battle of Sekigahara.