Scherzer continued his brilliance into the 2013 ALCS against the eventual World Series champion Boston Red Sox. In Game 2, he no-hit Boston for innings before surrendering two hits and a run in the bottom of the sixth. He left the game with a 5–1 lead after seven innings, striking out 13. However, a quartet of Tiger relievers blew the lead in the eighth inning, and Boston won it, 6–5, on a walk-off single in the ninth. Scherzer was the losing pitcher in the Tigers' 5–2 loss in Game 6, the deciding and final game of that series.