Theriot won the World Series with the San Francisco Giants in 2012. In game 4 of the Series, Theriot was used as a designated hitter for the first time in his major league career. In the 10th inning, he hit a leadoff single and eventually scored the go-ahead and winning run (coincidentally being driven in by Scutaro, who had taken his spot in the lineup 2 months before), which gave the Giants the clinching victory in a four-game sweep of the Detroit Tigers. As it turned out, Theriot scored the game- and world series-clinching run in his final on-field action in MLB.