Perry campaigned for the UK to remain in the EU during the 2016 membership referendum, and argued after the vote that some members of her party were "like jihadis" in their support for a "hard Brexit" and said the tone of the debate on leaving the European Union "borders on the hysterical". She was one of only seven Conservative MPs to vote for an amendment arguing that Parliament should have the final say on any deal to leave the EU. She subsequently voted with her party in approving the decision to invoke Article 50.