Following the Tree of Life synagogue massacre in Squirrel Hill, Pittsburgh, Weiss was a guest on "Real Time with Bill Maher" in early November 2018. She said of American Jews who support President Donald Trump: "I hope this week that American Jews have woken up to the price of that bargain: They have traded policies that they like for the values that have sustained the Jewish people—and frankly, this country—forever: Welcoming the stranger; dignity for all human beings; equality under the law; respect for dissent; love of truth." In 2019, "The Jerusalem Post" named Weiss the seventh most influential Jew in the world.