On 26 January 2020, he started his first game after being a year out against Leganés that ended up as a goalless draw. He was subbed off for Ivan Šaponjić in 88th minute. On 18 February, he started the home leg of the Champions League round-of-16 fixture against ruling champions Liverpool that ended up as a 1–0 victory. On 10 August, Atlético announced that Vrsaljko and teammate Ángel Correa were both positive for COVID-19, ruling them out of the team's quarter-final fixture against RB Leipzig.