Sérurier led a division in Napoleon Bonaparte's Italian campaign of 1796, except during bouts of illness. He especially distinguished himself at the Battle of Mondovì and the Siege of Mantua. In 1799, he again fought in Italy during the War of the Second Coalition at Verona, Magnano and Cassano, being captured in the latter action. After being paroled, he supported Napoleon's rise to political power in the Coup of 18 Brumaire in late 1799. The apex of his career occurred on 19 May 1804 when Napoleon appointed him a Marshal of the Empire. His active military career over, Sérurier served in the French Senate and was ennobled by Napoleon. In 1814 as the First French Empire was crumbling, he burned all the many flags captured by the French armies. His troops called him the "Virgin of Italy" for his rigorous standards of discipline and honesty in an army known for generals who enriched themselves by plundering the conquered territories. His surname is one of the names inscribed under the Arc de Triomphe, on Column 24.