Isaac Makwala (born 24 September 1985) is a Motswana sprinter who specializes in the 400 metres. He was the gold medallist at the Commonwealth Games in 2018. He has also won continental titles at the distance, winning at the 2015 African Games and twice at the African Championships in Athletics (2012, 2014). He has represented his country at the 2016 Summer Olympics, three times at the Commonwealth Games, and five times at the World Championships in Athletics (2007, 2009, 2013, 2015, 2017). With the Botswana 4 × 400 metres relay team he has won the bronze medal at the 2020 Tokyo Olympics, a silver medal at the 2017 IAAF World Relays and medals at the African Games and Championships.