On 30 July 2010, Khedira moved to Real Madrid after 98 Bundesliga appearances for an undisclosed fee, signing a contract until 2015. Khedira made his debut on 13 August in a friendly match against Bayern Munich, which Real Madrid won 4–2 on penalties for the Franz-Beckenbauer-Cup. His league debut came sixteen days later, in a 0–0 away draw against Mallorca. He made 40 appearances across his first season in Spain and won his first club honour on 20 April 2011 as his team won the Copa del Rey final against El Clásico rivals FC Barcelona.