The Indians swept Boston in the ALDS and Miller completed four innings in two appearances, permitting two hits, walking two and striking out seven. He played in two innings each of Games 1 and 2 in the American League Championship Series (ALCS) against the Toronto Blue Jays, striking out ten of 12 batters faced. After striking out Kevin Pillar in the seventh inning of Game 2, he matched Phil Coke in the 2012 World Series as the only pitchers to strike out at least five consecutive batters in the postseason. Miller also became the first pitcher in major league history to strike out at least five batters each on consecutive days. Covering his first four appearances in the 2016 postseason, he struck out 17 in innings.