In 2015,Dos Santos was called up to Mexico's friendly against Ecuador and Paraguay. Jonathan did not start nor play in Ecuador's friendly, but he started in Paraguay's friendly which led to a 1–0 win against them at Arrowhead Stadium in Kansas City, Missouri. He was called back up for two friendlies against Costa Rica and Honduras where both matches were drawn, and he was also called up for the 2015 Gold Cup, starting in every match as Mexico won the tournament.