At the Second Battle of Corinth on October 3 and 4, the 2nd Missouri Infantry was in Colonel Elijah Gates' brigade, along with the 16th Arkansas Infantry Regiment, 3rd Missouri Infantry Regiment, 5th Missouri Infantry Regiment, 1st Missouri Cavalry Regiment, and Wade's Missouri Battery. On October 3, the 2nd Missouri Infantry reinforced the brigade of Brigadier General Martin E. Green, and helped Green's brigade defeat a stubborn Union defensive position by enfilading the 11th Missouri Infantry Regiment. The next day, Gates' brigade, including the 2nd Missouri Infantry, charged the Union interior line. The attack was aimed for a fortification known as Battery Powell. The Confederate charge hit the division of Brigadier General Thomas A. Davies, breaking the Union line. The Confederate charge was also able to drive the Union artillerymen defending Battery Powell out of the fortification. The 2nd Missouri Infantry charged the 6th Wisconsin Battery, driving the battery's crews from the guns and taking the pieces. The Confederate charge had broken a large hole in the Union line. However, reinforcements were not sent to follow up the breakthrough, and a Union counterattack drove the 2nd Missouri Infantry and the rest of Gates' brigade from the ground they had won. At Second Corinth, the regiment lost 47 men killed, 107 wounded, and 91 missing, for a total of 245. The regiment then spent the next several months in camp.