The current settlement dates to 1207, when, following the destruction of Mosynopolis by the Bulgarian tsar Kaloyan, the remnant population fled and established themselves within the walls of the abandoned fortress. Since then the population had been increasing continuously until it became an important town within the area. In 1331 John Kantakouzenos referred to her as "Koumoutzina" in his account of the Byzantine civil war of 1321–1328. In 1332 Andronikos III Palaiologos set camp in Komotini to face Umur Bey of Smyrna at the Panagia village close to the Panagia Vathirryakos (Fatirgiaka) monastery. However, Umur departed without a battle. In 1341 the historian Nikephoros Phokas referred to the town with its current name. In 1343, during the civil war between John VI Kantakouzenos and John V Palaiologos, Komotini along with the neighbouring forts of Asomatos, Paradimi, Kranovouni and Stylario joined Kantakouzenos' side. John VI Kantakouzenos escaped to Komotini to survive from a battle with the army of the Bulgarian brigand Momchil near the already ruined Mosynopolis.