On June 23, 2016, Labissière was selected by the Phoenix Suns with the 28th overall pick in the 2016 NBA draft, becoming the highest drafted Haitian player since Samuel Dalembert (26th overall in 2001). His rights were later traded to the Sacramento Kings on draft night, and on July 15, he signed his rookie scale contract with the Kings. Labissière made his NBA debut on November 5, 2016, recording eight points and three rebounds in 15 minutes off the bench in a 117–91 loss to the Milwaukee Bucks. On February 23, 2017, in just his ninth game of the season, Labissière had a season-high 12 points in a 116–100 win over the Denver Nuggets. On March 1, 2017, in his first career start, Labissière had 10 points and five rebounds in 15 minutes in a 109–100 loss to the Brooklyn Nets. On March 15, 2017, he scored 21 of his career-high 32 points in the fourth quarter of the Kings' 107–101 win over Phoenix, becoming the first rookie from the 2016 draft class to score at least 30. He also had 11 rebounds to record his first career double-double. He became the youngest Kings player to record a 30-10 game and the fourth Kings player to do it as a reserves since the 1984–85 season. His points total was the highest for a Kings first-year player since teammate Ben McLemore scored 31 in 2013–14. Labissière became only the 41st player in NBA history to score at least 32 points while age 20 or younger—the only other player to achieve this feat in franchise history is Tyreke Evans. During his rookie season, he had multiple assignments with the Reno Bighorns of the NBA Development League.