Born in Treviso, Buso initially began his career playing as a striker or as a centre-forward with Juventus in Serie A in 1985, at the age of 16, immediately winning the 1985–86 Serie A title and the 1985 Intercontinental Cup, although he was mainly a reserve player at the club, behind forwards Aldo Serena, Ian Rush, and Alessandro Altobelli. He later moved to Fiorentina in 1989, where he was deployed alongside Roberto Baggio and Oscar Dertycia as a winger, or as a supporting striker. During his time at the club, he played and scored in the 1990 UEFA Cup Final against his former team, although Fiorentina would lose the tournament. He subsequently moved to Sampdoria in 1991, where he won the 1991 Supercoppa Italiana. He began to be deployed as a midfielder as his career progressed, and he later also played for Napoli (1993–1996), Lazio (1996–97), Piacenza (1997–2000), Cagliari (2000–01), ending his career with La Spezia in Serie C1 (2001–04).