Nikola Hristić was married to Juliana (born Hadži-Jovanović), the granddaughter of Toma Vučić-Perišić, one of the leaders of the Serbian Revolution. Hristić's son – Kosta (1852–1927) – was a lawyer, diplomat and minister of justice; his daughter Poleksija (1861–1933) was married to Laza Lazarević, the famed Serbian physician writer.