On 5 February 2021, Vučević scored a career-high 43 points, grabbed a season-high 19 rebounds and dished out 4 assists in a 123–119 win over the Chicago Bulls. He succeeded in two free throw shots with 2.6 seconds left to play, ending the Magic's fourth losing streak. In his efforts, Vučević joined Shaquille O’Neal and Dwight Howard as the third player in franchise history to log at least 43 points and 19 rebounds in a game. On 19 February, Vučević logged his third career triple-double with 30 points, 16 rebounds and 10 assists in a 124–120 win over the Golden State Warriors, becoming the second center (along with Nikola Jokić) to score a 30-point triple-double with zero turnovers since 1985. He also set a franchise record for the most triple-doubles for the center position. On 23 February, Vučević was named an Eastern Conference reserve for the 2021 NBA All-Star Game.