Cortés's fifth letter to King Charles attempts to justify his conduct, concludes with a bitter attack on "various and powerful rivals and enemies" who have "obscured the eyes of your Majesty". Charles, who was also Holy Roman Emperor, had little time for distant colonies (much of Charles's reign was taken up with wars with France, the German Protestants and the expanding Ottoman Empire), except insofar as they contributed to finance his wars. In 1521, year of the Conquest, Charles was attending to matters in his German domains and Bishop Adrian of Utrecht functioned as regent in Spain.