The film had its world premiere on May 15, 2016, at the Cannes Film Festival, where it won the Prix du Jury. The film was released in a limited release on September 30, 2016, by A24. In 2017, Lane starred in "Born in the Maelstrom", a short film directed by Meryam Joobeur. In 2018, Lane starred in "Hearts Beat Loud", opposite Nick Offerman and Kiersey Clemons, directed by Brett Haley, and "The Miseducation of Cameron Post" directed by Desiree Akhavan. "The Miseducation of Cameron Post" won Top Prize at the 2018 Sundance Film Festival and has been praised for its “sensitive, understated portrayal of adolescent self-doubt and discovery.” In 2019, Lane played Alice Monaghan in "Hellboy", directed by Neil Marshall.