The Dominican Republic Olympic Committee selected Castillo as the Dominican Republic Flag bearer for the 2010 Central American and Caribbean Games held at Mayagüez, Puerto Rico, from July 17, 2010, to August 1, 2010. In the volleyball tournament of the Regional Games, she won with her team the gold medal. She later played in Chiapas, Mexico winning the Best Libero and Best Receiver awards, along with the gold medal with her National Senior Team at the 2010 Final Four Cup. Castillo later participated in her first Senior World Championship in Japan, finishing second in digs and Best Libero categories, and being 17th with her national team.