During the Persian Gulf War's Operation Desert Storm, "Comfort" received a call to activate for Desert Shield/Desert Storm 9 August 1990 and departed Baltimore 11 August. "Comfort" was positioned in proximity to Kuwait, just off the coast of Saudi Arabia near Khafji. On 12 March 1991, "Comfort" was under way on her return trip home. She arrived in Baltimore on 15 April 1991. While deployed, "Comfort" traveled more than and consumed almost of fuel. More than 8,000 outpatients were seen, and 700 inpatients were admitted including four sailors injured in a high-pressure steam leak on . 337 surgical procedures were performed. Other notable benchmarks include: more than 2,100 safe helicopter activities; 7,000 prescriptions filled; 17,000 laboratory tests completed; 1,600 eyeglasses made; 800,000 meals served and 1,340 radiographic studies, including 141 CT scans.