In October 1942, Sinenko was appointed commander of the 3rd Tank Corps in the Reserve of the Supreme High Command. He was promoted to major general of tank forces on 10 November. The corps was sent to the Southwestern Front in January 1943 to fight in Operation Gallop, during which it captured Kramatorsk and Druzhkovka. In mid-1943 the corps fought in the Battle of Kursk as part of the 2nd Tank Army. From October, Sinenko served as chief of the Combat Training Directorate, and from April 1944 was First Deputy Chief of the Main Directorate for Formation and Combat Training of the Armed and Mechanized Forces of the Red Army. In September 1944 he was appointed first deputy commander-in-chief of the 5th Guards Tank Army. On October, during the Memel Offensive, Sinenko became acting commander of the 3rd Guards Tank Corps when corps commander Lieutenant General Aleksei Panfilov was replaced due to illness. Under his command, the corps crossed the Minija and fought its way to Memel. He was credited with "skillful organization" of the repulse of German tank counterattacks as the corps held its line before infantry units could catch up to its advance. Sinenko returned to his duties as army first deputy commander by 16 October after Panfilov recovered.