Grilli was named to the 2013 National League All-Star team, and pitched the ninth inning of the 2013 MLB All-Star Game. After giving up a leadoff triple to Prince Fielder, he retired the next three batters for a scoreless inning. On July 22, Grilli became the first Pirate since 1992 to be on the cover of "Sports Illustrated"; in that night's game, he injured his forearm and was placed on the 15-day DL, another victim of the magazine's cover jinx. His replacement at the closer position was Mark Melancon. Grilli was activated from the DL on September 3, resuming his role as closer. He helped the Pirates to the 2013 playoffs, the team's first postseason appearance since 1992. Grilli pitched a scoreless ninth inning in the Pirates win over the Cincinnati Reds in the 2013 National League Wild Card Game. He appeared in three games in the Pirates series loss to the St. Louis Cardinals in the 2013 National League Division Series. Grilli has not had a run charged against him in nine career playoff appearances spanning 6 innings. In his 54 appearances in 2013, Grilli went 0–2 with a 2.70 ERA going 33 for 35 in save opportunities, striking out 74 in 50 innings.