Lusseyran was born in Paris, France. He became totally blind in a school accident at the age of 7. He soon learned to adapt to being blind and maintained many close friendships, particularly with one boy named Jean. At a young age he became alarmed at the rise of Adolf Hitler in Germany and decided to learn the German language so that he could listen to German radio broadcasts. By 1938, when Nazi Germany annexed Austria, he had accomplished this task.