Pavlyuchenkova has also had success in doubles, having won five doubles titles on the WTA Tour and eight doubles titles on the ITF Circuit. She achieved a career-high ranking of No. 21 on 16 September 2013. She reached a total of six quarterfinals in the discipline across all four Grand Slams (at the Australian Open in 2013, the French Open in 2013 and 2021, Wimbledon in 2014, and the US Open in 2015 and 2018) as well as winning one Premier Mandatory title at the 2013 Madrid Open with Lucie Šafářová. She also won the Olympic gold medal at the 2020 Summer Olympics in the mixed doubles tournament with Andrey Rublev.