The film had its world premiere at the Venice International Film Festival on 2 September 2018, where it won the Silver Lion for Best Direction, and was theatrically released in the United States on 21 September 2018. "The Sisters Brothers" received positive reviews from critics, with most praise going to its performances, characters, direction and soundtrack. It was a box office bomb, grossing $13.1 million against its $38 million production budget. It was the final feature film featuring Rutger Hauer released before his death, although he had finished filming several projects released after his passing.