Brenner immigrated to Palestine (then part of the Ottoman Empire) in 1909. He worked as a farmer, eager to put his Zionist ideology into practice. Unlike A. D. Gordon, however, he could not take the strain of manual labor, and soon left to devote himself to literature and teaching at the Gymnasia Herzliya in Tel Aviv. According to biographer Anita Shapira, he suffered from depression and problems of sexual identity. He was murdered in Jaffa in May 1921 during the Jaffa riots.