Van der Wel had already been assigned the stage name "100% Isis" when she started her performance career at age 17 with a residency at Amsterdam club RoXY from 1992 -1994. This launched her long running International career, performing at dance venues and festivals in Europe, South America, Asia, USA and Africa. In 1993 she performed at a Prince concert in Brussels. Together with Eric Nouhan, Isis received her first production assignment in 1995 given by Bols. From 1995 until 2000 Isis became a resident DJ at Amsterdam club "Chemistry" (aka 'Escape', Rembrandtplein). In 1995 she was contracted by EMI, Virgin, Ariola, and BMG. In 1996 and 1997 Isis’ mix albums ("100% Isis 1" and "100% Isis 2") were ranked on various Electronic dance music national top ten charts. At the World Expo '98 in Lisbon Portugal, Isis performed as an official representative of the Netherlands. Isis was subsequently asked to perform during Holland Festival in 2000. Her mix album "Reformation" was ranked in the top ten mix albums of 2001. In 2002 her talent was recognized globally and she was ranked in top ten of worldwide female Tech-House DJ's. In 2003 she was ranked in the top 600 of the best DJ's worldwide. At the World Climate Summit 2009 in Copenhagen Isis achieved her audience capacity record, reaching up to 100,000 spectators.