Some of the inhabitants of this area before the Conquest were the Cohuixas and the Chontals. The indigenous community located at what is now the southern edge of the town dates back to at least 350 C. E. This community was an important regional ceremonial center as well as the headquarters for the guardian soldiers. It was also closely associated with the production of cotton and cotton products, a valuable commodity at the time. Ixcateopan was one of the last cities to be subjugated by the Aztec Empire. The location served as a point to gather and then distribute tribute from surrounding areas. Mexica from other parts of the Aztec Empire, including soldiers, came here due to the wars between them and the Purépecha Empire. Because of this, Ixcateopan, originally a purely Chontal city, became multicultural.