Having spent the vast majority of his career as a seventh inning and eighth inning reliever, Herrera took over the role of the Kansas City Royals' closer following a sidelining injury to Wade Davis in 2016. Herrera collected 12 saves in 15 opportunities as closer. He ended his season with a 2.75 ERA, striking out 86 in 72 innings pitched surrendering a career low 12 walks in a season. Herrera was named to the 2016 MLB All-Star Game, his second consecutive trip to the Midsummer Classic. In 72 games, he had an ERA of 2.75 with 12 saves.