On 24 June 2012, after just over a year of illness, Roqué lost his battle against cancer and died, two weeks before his 24th birthday. His death prompted a series of tributes on Twitter, including from several international players competing in UEFA Euro 2012, and on 1 July, after the final of the continental competition, Spain goalkeeper Pepe Reina (his former Liverpool teammate) wore a Betis shirt featuring Roqué's name during the players' victory lap of the Olympic Stadium in Kiev; also, Cesc Fàbregas wore a shirt with the names of Roqué, Dani Jarque, Manolo Preciado and Antonio Puerta.