Cape Verde sent a delegation to compete at the 2016 Summer Paralympics in Rio de Janeiro, Brazil, from 7 to 18 September 2016. This was the nations' fourth appearance at a Summer Paralympic Games since it made its debut at the 2004 Athens Summer Paralympics. Cape Verde was represented by two athletes in Rio de Janeiro: sprinter Gracelino Barbosa and javelin thrower Márcio Fernandes, who qualified for the Games by meeting the qualification standards of their events. Barbosa won the country's first Paralympic medal with his third-place finish in the men's 400 metres T20 competition and Fernandes came ninth in the F44 men's javelin event.