Pruss was commander of the airship during the "Hindenburg" disaster of 6 May 1937. This was his first time commanding a trip to Lakehurst. Pruss and several crew members rode the "Hindenburg" down to the ground as it burned, then ordered everybody out. He carried radio operator Willy Speck out of the wreckage, then looked for survivors until rescuers were forced to restrain him. Pruss, however, suffered extensive burns and had to be taken out by ambulance to Paul Kimball Hospital in Lakewood. The burns were so extensive that he was given last rites, but although his face was disfigured for the rest of his life, his condition improved over the next few months. Pruss was unable to testify at investigative committees, but officially he was not held responsible.