It is a hip hop song with lyrics about breast cancer and empowerment, representing the struggle of women who are diagnosed with it. "Yo Contra Ti" has been critically well received, garnering Susan G. Komen Puerto Rico and J. Walter Thompson numerous awards for its campaign, as well as five nominations at the 2018 Cannes Lions International Festival of Creativity for the song and music video. "Yo Contra Ti" was nominated for a &lt;a href="Latin%20Grammy%20Award%20for%20Best%20Urban%20Fusion/Performance"&gt;Latin Grammy Award for Best Urban Fusion/Performance&lt;/a&gt; at the 19th Latin Grammy Awards. Commercially, the single failed to rank on any chart, although it was reported that the campaign has amassed over a million dollars for Susan G. Komen.