The following year, he began by focusing on the 2010 IAAF World Indoor Championships, and he won the 60 m at the UK trials in 6.50 seconds (a time only he had bettered in the previous two seasons). His closest competitor, Ivory Williams, received a ban for marijuana usage, leaving Chambers as a strong favourite. He was the fastest in all rounds of World 60 m competition, and surged ahead of Mike Rodgers in the final to win his first world title with a time of 6.48 seconds. Banned from the 2010 Commonwealth Games, he set his sights on making the team for the 2010 European Athletics Championships.