On April 11, 2017, Sin Cara was moved to the SmackDown brand as part of the Superstar Shake-up. On the October 17 episode of "SmackDown Live", Sin Cara started a feud with the United States Champion Baron Corbin, but on November 6, Sin Cara revealed on Twitter that he suffered a legitimate leg injury during the European tour against Baron Corbin. However, the injury was not severe and he was cleared to compete shortly afterwards. On the November 14 episode of "SmackDown Live", Sin Cara failed to win the United States Championship, after being defeated by Corbin. At WrestleMania 34 on April 8, 2018, Sin Cara competed in the André the Giant Memorial Battle Royal, but failed to win. On the May 29 episode of "SmackDown Live", Sin Cara tried to reconnect with Andrade "Cien" Almas only to be blown off. At Extreme Rules on July 15, Sin Cara lost to Almas. On August 15, it was reported that Sin Cara underwent knee surgery. In March 2019, he was cleared to return to in-ring action. At Super ShowDown on June 7, 2019, Sin Cara competed in the 51-man battle royal, but failed to win.