The 1904 Republican National Convention selected Fairbanks as the running mate for President Theodore Roosevelt. As vice president, Fairbanks worked against Roosevelt's progressive policies. Fairbanks unsuccessfully sought the Republican nomination at the 1908 Republican National Convention and backed William Howard Taft in 1912 against Roosevelt. Fairbanks sought the presidential nomination at the 1916 Republican National Convention, but was instead selected as the vice presidential nominee, serving on a ticket with Charles Evans Hughes. In the 1916 election, the Republican ticket lost to the Democratic ticket of President Woodrow Wilson and Vice President Thomas R. Marshall.