He took charge of the final of the 2012 UEFA European Under-19 Football Championship as a UEFA Elite referee. On 18 August 2020, UEFA named 37-years old Makkelie as the referee for the 2020 UEFA Europa League Final between Sevilla and Inter Milan. Previously, he was an additional assistant referee in the 2018 UEFA Europa League Final. He also refereed the semifinal between Brazil's Palmeiras and Mexico's UANL in the 2020 FIFA Club World Cup in Qatar. Makkelie was selected as a referee for the UEFA Euro 2020, where he was in charge of two group stage matches, the R16 clash between England and Germany and the Wembley semi-final between England and Denmark.