Whitlock was beaten 4–0 in the second round of the 2017 World Championship as Darren Webster averaged 104.64. In the final of the second UK Open Qualifier Whitlock took out a 154 finish with his opponent Gary Anderson waiting on 20 to lead 5–3 and went on to win 6–4. He also claimed the fifth event by seeing off Ronny Huybrechts 6–3. At the main event progressed through to the quarter-finals and held a 7–4 advantage over Daryl Gurney, before losing five legs in a row. Whitlock fought back to force a last leg shoot-out, but lost it to be defeated 10–9. His third ranking event title of 2017 came a week later as he overcame Gary Anderson 6–5 in the quarter-finals and Kim Huybrechts 6–4 in the semis, before dispatching Darren Johnson 6–3 to win the fourth Players Championship.