The regiment served in the Mexico City campaign and was in the Battle of Contreras, Battle of Churubusco, Battle of Molino del Rey and at the Battle of Chapultepec where it took a distinguished part. At the Battle of Chapultepec it was in support of the storming force, but joined with it as a part of the assault on the citadel. Sixteen officers and eleven enlisted men of the regiment were mentioned by name in the report of Major General Gideon Pillow for meritorious conduct in this battle, among the former being Second Lieutenant R. C. Drum, later a general. Another officer who served with the regiment was Major William B. Taliaferro, who became a major general in the Confederate States Army during the American Civil War.