Kondapalli Seetharamaiah, at a young age, joined the communist movements. He went on to become the Krishna District Secretary of the Communist Party of India. His CPI unit was active during the Telangana Rebellion. When the Communist Party of India was divided in 1964, Seetharamaiah withdrew from political life. He began working as a Hindi teacher at St. Gabriel's High School in Warangal. In Warangal he befriended K.G. Sathyamurthy. Both men joined the Communist Party of India (Marxist-Leninist). Seetharamaiah became a member of the Andhra Pradesh State Committee of CPI(ML). When the Communist Party of India (Marxist-Leninist) was torn by internal strife, Seetharamaiah joined the Central Organising Committee, Communist Party of India (Marxist–Leninist) in 1972. In August 1974, the Andhra Pradesh State Committee of COC, CPI(ML) was organised, with Seetharamaiah as one of its three members.