During the 2005 NLCS, Lidge gave up a 3-run home run to Albert Pujols in Game 5 in Houston which forced a Game 6 back in St. Louis, which the Astros would win to clinch their first World Series berth in franchise history. In his very next appearance, Lidge gave up a walk off home run to Scott Podsednik in Game 2 of the 2005 World Series and the series winning run and hit in Game 4 to go 0-2 in the series and complete the White Sox sweep of the Astros.