In the government of Chancellor Angela Merkel, Reiche first served as Parliamentary State Secretary at the Federal Ministry for the Environment, Nature Conservation and Nuclear Safety under successive ministers Norbert Röttgen (2009-2012) and Peter Altmaier (2012-2013) from 2009 to 2013. Following the 2013 elections, she was named Parliamentary State Secretary at the Federal Ministry of Transport and Digital Infrastructure, this time under the leadership of minister Alexander Dobrindt.