The station lies on the line, built by the Chemins de fer Orientaux (CO), from Istanbul to Vienna. The railway reached Lagyna during Ottoman rule, when in 1873, when the line from Istanbul to Edirne and Bulgaria was opened. A 112 km branch from Pythio to Alexandroupoli (then known as Dedeağaç) was opened in 1874. When the railway was built it was all within the Ottoman Empire. After World War I and the subsequent Greek-Turkish War from 1919 to 1922, and finally peace in the form of the Lausanne treaty, the Chemins de fer Orientaux (CO) ended up having a network straddling Turkey and Greece, Didymoteicho became part of Greece and the line administrated by Greece.