Honduran Olympic Committee () sent the nation's second-largest delegation to the Games, matching its roster size with Beijing 2008. A total of 26 athletes, 25 men and 1 woman, were selected to the Honduran team across eight sports, with the men's football squad returning for its third consecutive appearance at these Games. Among the Honduran athletes were weightlifter Cristopher Pavón, butterfly swimmer Allan Gutiérrez, taekwondo fighter Miguel Ferrera, and track sprinter Rolando Palacios, who led the squad as the nation's flag bearer in the opening ceremony.