He was given squad number 11, and made his competitive debut on 20 August in the opening Serie A matchday against his former side Fiorentina, featuring full-90 minutes as Inter won 3–0. Vecino scored his maiden Inter goal six days later in the next match against Roma, netting the third goal in an eventual 1–3 away win, the first win at Stadio Olimpico over Roma after nine years.