Protić returned to Serbia again and took part in the Second Serbian Uprising. He participated in the negotiations with Marashli Ali Pasha in Ćuprija. During these negotiations, Protić compiled a complaint on behalf of the Serbian people addressed to the Sultan Mahmud II, and in that complaint all crimes of the Turks against the Serbs after the end of the First Serbian Uprising. In addition, he helped to translate this complaint into Turkish. With Marashli Ali Pasha's approval and with his envoys, he left Ćuprija before Reşid Mehmed Pasha, to inform him about the agreement between Marashli Ali Pasha and Miloš Obrenović, and thus to prevent an attack on the insurgents from the Bosnian side. Another insurgent Pavle Cukić was dissatisfied with the peace agreement, which prince Miloš made a deal with Marashli Ali Pasha, so he opposed and exiled himself in the Manasija monastery. Anta Protić helped Pavle Cukić a lot to persuade him to surrender to Prince Miloš, but to no avail.