On 21 May 2019, he was included in Lionel Scaloni's final 23-man Argentina squad for the 2019 Copa América. In Argentina's final group match against Qatar on 23 June, Agüero scored the second goal in a 2–0 win, which enabled his team to advance to the knock-out stages. On 28 June, in the quarter-finals of the tournament, Agüero assisted Lautaro Martínez's opening goal, and was also involved in the second goal, scored by Giovani Lo Celso, as Argentina defeated Venezuela 2–0 to advance to the semi-finals. In the third-place match against Chile on 6 July, Agüero scored the opening goal in an eventual 2–1 win, to help Argentina capture the bronze medal.