Miedema helped the Dutch qualify for their first-ever FIFA World Cup finals, scoring all three of her side's goals in the two-leg final of the UEFA qualification play-offs against Italy in November 2014. She finished as the top scorer in the qualification campaign with 16 goals. At the finals in Canada, she played all four matches, three group stage games and the round of 16 match, a defeat against Japan. She did not score in Canada. At the 2017 UEFA Women's European Championship, held in the Netherlands, Miedema scored four times, including in the semi-final win over England and in the final against Denmark. Her goals helped secure the first ever title for the Dutch women.