From 334 BCE to 331 BCE, Alexander the Great, defeated Darius III in the battles of Granicus, Issus and Gaugamela, swiftly conquering the Persian Empire by 331 BCE. Alexander's empire broke up shortly after his death, and Alexander's general, Seleucus I Nicator, tried to take control of Iran, Mesopotamia, and later Syria and Anatolia. His empire was the Seleucid Empire. He was killed in 281 BCE by Ptolemy Keraunos.