The regiment sailed for India in June 1857 to help suppress the Indian Rebellion. It arrived at Calcutta in September 1857 and was welcomed by General Sir Colin Campbell. Under heavy enemy fire, the regiment, together with the 4th Punjab Infantry Regiment took part in the storming and capture of Sikandar Bagh, a walled garden fortification, on 16 November 1857. Six Victoria Crosses were awarded to members of the regiment for their service in this action. At daybreak on 17 November 1857 the Regimental colour was hoisted on top of a tower as a signal to the beleaguered garrison of the Residency at Lucknow. On the night of 19 November 1857 the regiment provided covering fire as the evacuation of the Residency took place. The regiment then saw action again at the Second Battle of Cawnpore in December 1857.