Sun Ce was assassinated in 200 CE while he was out on a hunting expedition and was succeeded by Sun Quan. In 208, Zhou Tai participated in the Battle of Jiangxia against Huang Zu. Later that year, Zhou Tai fought at the Battle of Red Cliffs under the command of Zhou Yu and Cheng Pu, and the allied forces of Sun Quan and Liu Bei scored a major victory over Cao Cao's forces. Zhou Tai was also involved in the Battle of Jiangling, a follow-up to Red Cliffs, and Sun Quan's forces defeated Cao Cao's general Cao Ren and captured Nan Commandery (南郡; around present-day Jingzhou, Hubei). After the battles, Zhou Tai was ordered to garrison at Cen County ().