Oble served as president of African Women Ministers and Parliamentarians and a founding member of the Women Lawyers' Association. After the election of Ellen Johnson Sirleaf in neighbouring Liberia in 2005, many women encouraged her to run for the presidency. In 2010, she was a candidate in the presidential elections, the first woman to contest the position. Although she beat six of the other 13 candidates, she only received 0.27 percent of the vote. She chose to support Laurent Gbagbo in the second round of voting. After his election, she was appointed as his spokesperson, and then from 5 December 2010 to 11 April 2011, she served as Minister of Education in the Gilbert Aké government, which was not recognised by the international community. On 18 December 2010, she spoke on behalf of Gbagbo and called for the immediate withdrawal of UN and French troops from the country, saying the UN was guilty of "serious missteps" and "contempt" for the country's institutions. On 11 January 2011, the European Union placed Oble under sanctions as a member of the Ake N'Gbo government. After Gbagbo's arrest on 11 April 2011, bringing an end to the Second Ivorian Civil War, she was the only minister not disturbed by the new leaders.