Sémmane represented Denmark in the Eurovision Song Contest in Athens on 20 May 2006. She won the chance to sing on the Dansk Melodi Grand Prix on February 11, 2006 with the song "Twist of Love", written by Niels Drevsholt, which she later went on to sing at the Eurovision Song Contest. At the age of 17, she was the youngest participant to take place in the Danish Melodi Grand Prix. She placed 18th at Eurovision.