Henry Middleton (1717 – June 13, 1784) was a planter and public official from South Carolina. A member of the colonial legislature, during the American Revolution he attended the Continental Congress and served as that body's presiding officer for a few days in 1774. He left Congress before it declared independence. Back in South Carolina, he served as president of the provincial congress and senator in the newly created state government. After his capture by the British in 1780, he accepted defeat and returned to the status of a British subject until the end of the war.