On 3 May 2018, Payet played in the Europa League semi-finals away to Red Bull Salzburg as Marseille played out a 1–2 away loss but secured a 3–2 aggregate win to secure a place in the 2018 UEFA Europa League Final. During the Europa League Final against Atlético Madrid, Payet suffered a hamstring injury and was substituted in the 32nd minute of the first half, leaving the field in tears. Marseille would go on to lose 3–0.