Wehle began her career practicing law as a clerk to a federal judge, then at the Federal Trade Commission, the Whitewater investigation, U.S. Attorney's Office, and private practice. Wehle was of counsel in the litigation group of the Washington, D.C. tax boutique Caplin &amp; Drysdale, where her work focused on asbestos creditors' rights and campaign and election law litigation. She has also practiced before the United States Supreme Court and argued several cases in the United States Court of Appeals for the D.C. Circuit.