Agüero was included in Gerardo Martino's 23-man squad for the Copa América Centenario and scored his first goal of the tournament in Argentina's second group match, a 5–0 win over Panama on 10 June 2016, which allowed them to advance to the quarter-finals of the competition. Agüero considered retiring from international football shortly after losing against Chile in a penalty shootout in the final of the tournament for a second consecutive time.