Zarco signed a deal with Pramac Racing in September 2020 for the 2021 season. Currently halfway through 2021, Zarco has experienced new career highs including four podium finishes, the highest points total of any of his seasons in MotoGP, and second place in the championship behind compatriot Fabio Quartararo. Zarco has also been the highest scoring rider on the factory Ducati in 2021, outpacing not only his rookie teammate Jorge Martin but also factory team riders Jack Miller and Francesco Bagnaia. Zarco and Quartararo became the first two Frenchman to share the podium in the premier class since the 1950s after the second Qatar race and the two repeated the result at the Le Mans round.