Nash quickly became engaged in revolutionary activities, and served as a delegate to the first three Patriot provincial congresses. In 1775, he was named lieutenant colonel of the 1st North Carolina Regiment under Colonel James Moore, and served briefly in the southern theater of the Revolutionary War before being ordered north. Nash was made a brigadier general in 1777 upon Moore's death, and given command of the North Carolina brigade of the Continental Army under General George Washington. He led North Carolina's soldiers in the Philadelphia campaign, but was wounded at the Battle of Germantown on October 4, 1777, and died several days later. Nash was one of ten Patriot generals to die from wounds received in combat between 1775 and 1781. He is honored by several city and county names, including those of Nashville, Tennessee; Nashville, North Carolina; and Nash County, North Carolina.