The 2021 Murray River Open was a tournament on the 2021 ATP Tour. It was played on outdoor hard courts in Melbourne, Australia. It was organised as a lead-up tournament to the 2021 Australian Open, and was held at the same venue, due to other tournaments in Australia being cancelled as a result from the COVID-19 pandemic. This tournament took place simultaneously with the 2021 Great Ocean Road Open and the 2021 ATP Cup.