In the shortened 2020 season, Adames played 54 games for the first place Tampa Bay Rays. He slashed .259/.332/.481 with 8 home runs and 23 RBIs. That year, the Rays won the American League pennant. Adames batted .143 with one RBI in the World Series, which the Rays lost to the Los Angeles Dodgers in six games. Adames was the last out of the 2020 World Series as Julio Urías retired the side, and got the save.