Agüero was named in the Argentine squad for the 2015 Copa América, and in a warm-up game on 7 June against Bolivia in San Juan, he scored his first international hat-trick in a 5–0 victory. On 13 June, he scored Argentina's opening goal of the tournament in a 2–2 group stage draw with Paraguay. Three days later at the same ground, he headed a cross from Manchester City teammate Pablo Zabaleta for a 1–0 win against holders Uruguay. At the semi-final stage, Agüero headed in Ángel Di María's cross as Argentina defeated Paraguay 6–1 to reach the 2015 Copa América Final. Agüero started the final against Chile, but was replaced in the 74th minute for Gonzalo Higuaín in an eventual penalty shootout loss.