After Sunderland failed to sign Hutton on a permanent deal, he returned to Spurs, scored in the opening game of the season, and won a penalty, allowing newly signed Rafael van der Vaart to convert and score Tottenham's first goal in the match, a 3–1 win against Wolverhampton Wanderers. He since started and played the full 90 minutes against Manchester United at Old Trafford in a 2–0 Premier League defeat. At the end of the 2010–11 season, he made 26 appearances for Spurs in all competitions. The next appearance, Hutton scored again, as Tottenham Hotspur lost to Bolton Wanderers. He was Tottenham's first choice right-back for the majority of the 2010–11 season, often being preferred to Croatian international Vedran Ćorluka on the right hand side of the Spurs defence. Hutton was also an important fixture in Tottenham's 2010–11 UEFA Champions League campaign that saw them reach the quarter-finals, including being part of the team that produced a memorable 3–1 victory over European champions Internazionale. However, his season ended in April, after suffering a knee injury, which ruled him out for the rest of the season.