The present structure dates from the 17th century however a much older church existed on its site. The original medieval chapel was built in 1417 by a nobleman Francesco Gattoand his wife Paola de' Castelli. On 22 January 1575 the chapel was visited by inquisitor Pietro Dusina on his apostolic visit to Malta. Prior to 1661 the chapel was owned by the Gatto Murina family. In 1661 the chapel was given to the church in Malta. The medieval chapel was damaged in the 1693 Sicily earthquake which destroyed much of Mdina including the medieval cathedral.