On 1 July 2008, Palermo announced to have finalised the signing of Lanzafame from Juventus in a co-ownership deal, for €2.5 million, as part of the deal that saw Amauri, move to Juventus, while Antonio Nocerino also transferred outright to Palermo . After a disappointing time with Palermo during the first half of the 2008–09 Serie A season, where Lanzafame saw little playing time and no first team action, co-owners, Juventus, ensured that a loan deal was executed, also wanting their youth product to remain in Serie A. On 26 December 2008, he moved from Palermo to Bari on loan for the remainder of the season. Lanzafame underwent a second successful spell with A.S. Bari, making 18 league appearances and scoring 2 goals. Following his second return from Bari, Lanzafame returned to Palermo, only to be loaned out to Serie A side, F.C. Parma. In his first full season of Serie A football, Lanzafame impressed, scoring 7 goals in 27 league matches. He also scored against his parent club in 3–2 win for Parma over Juventus on 9 May 2010.