Guramishvili began playing chess at age five. She regularly qualified for and participated in the World Youth Chess Championships from age ten onwards. She won a silver medal in the under-12 girls' division in 2003 and a gold medal in the under-16 girls' division in 2006. Guramishvili first qualified for the Georgian Women's Chess Championship at age 17. Her best finish was in 2009, when she came in joint second place and earned a WGM norm. Guramishvili was awarded the WGM title in 2009 at age 18 and the IM title in 2012 at age 21. She earned her last IM norm at the 2011 Nakhchivan Open, during which she defeated Sergey Fedorchuk, a Ukrainian Grandmaster (GM) rated 2662. Guramishvili has routinely performed well at the European Individual Women's Chess Championship, earning a double IM norm in 2010 and twice qualifying for the Women's World Chess Championship 64-player knockout tournament because of her 2013 and 2015 results. At the 2017 Women's World Championship, she eliminated higher-seeded Sarasadat Khademalsharieh and reached the round of 16. Guramishvili had her two best tournament performance ratings in 2016, with a career-best of 2509 at the Tata Steel Tienkamp.