Anderson took the fourth UK Open Qualifier with a 6–1 victory over James Wade, but at the main event suffered a huge surprise fourth round loss as amateur Barry Lynn won 9–3. He finished third in the Premier League to qualify for the semi-finals and rallied from 8–4 down against Phil Taylor to trail by one leg, but would be beaten 10–7. Anderson had an exceptional year in the invitational World Series events as he claimed the Dubai Masters, Auckland Darts Masters and Tokyo Darts Masters. He reached the semi-finals of the World Matchplay for the second time, but lost 17–8 to Taylor. Anderson's second Pro Tour title of 2016 was the 12th Players Championship which he won by edging out Terry Jenkins 6–5.