Born in La Seca, Province of Valladolid, Eusebio started playing professionally with hometown's Real Valladolid, being an automatic first-choice from an early age and moving to Atlético Madrid for 1987–88. After that sole season in Madrid he joined FC Barcelona, proceeding to be one of coach Johan Cruyff's most used squad members in the subsequent years – he played the full 90 minutes at both the victorious 1989 Cup Winners' Cup and the 1992 European Cup Finals.