Santa Cruz moved up to featherweight and fought his first fight on 2 May 2015. His opponent was announced as Mexican Jose Cayetano (17-3, 8 KOs) in a scheduled 10 round bout on the Mayweather vs. Pacquiao super fight undercard at the MGM Grand Arena. Santa Cruz won every round on all three judges scorecards (100-90, 3 times). Still undefeated, Santa Cruz boasted a record of 30 wins, no losses and 1 draw, with 17 inside the distance.