On 8 June 2017, Lozano was named in Mexico's 23-man squad for the FIFA Confederations Cup in Russia. In their final group stage match against the hosts, Lozano scored the second goal in a 2–1 win after chasing a long clearance from Héctor Herrera and beating goalkeeper Igor Akinfeev to the ball towards the edge of the box, allowing Lozano to nip in and head it into the open net. His performance led him to be named man of the match.