Mamlouk is said to be on good terms with all of Syria's intelligence agencies; the heads of the Air Force Intelligence Directorate and the Political Security Directorate were once his assistants. In July 2012 following the Damascus security HQ bombing, it was reported that Mamlouk would become the head of the National Security Bureau with the rank of minister overseeing the entire security apparatus, and that former military intelligence chief Abdel-Fatah Qudsiyeh would become his assistant.