Destroyed in the Great Fire of London in 1666, the church was rebuilt to a design by Sir Christopher Wren in 1678 at a cost of £4,687 4s 6d. The parish was united with that of St Mary Bothaw, also destroyed in the fire, but not rebuilt. The new church was 61 feet long and 42 feet wide. It had a tower and spire rising from the north-west corner of the building, with a total height of about 150 feet.