Ramírez got his only win of the year by pitching a scoreless inning on September 21 in a 1–0 victory over the Cubs. He got a save against the Diamondbacks on September 30, since Giants' manager Bruce Bochy wanted to rest closer Brian Wilson, in a 4–1 victory. Ramírez posted a 1–0 record, an 0.67 ERA, 15 strikeouts, and 27 innings pitched in 25 games for the Giants as they won the National League (NL) West and reached the playoffs for the first time since 2003. For the entire season, Ramírez had a 1–3 record, a 2.99 ERA, 46 strikeouts, and innings pitched in 69 games. Ramírez's only appearance in the NLDS against the Atlanta Braves came in Game 2 on October 8, when he gave up a home run to Rick Ankiel in the 11th inning and was charged with a loss (the Giants' only loss of the series) in the 5–4 defeat. In Game 2 of the NL Championship Series, Ramírez gave up two runs in of an inning as the Giants lost 6–1 to the Phillies. In Game 5, the Giants' other loss in the series, he gave up a run in innings as the Giants lost 4–2. On October 27, in Game 1 of the World Series, he gave up two runs in inning, but the Giants defeated the Rangers 11–7. He pitched scoreless innings in Game 3 on October 30, but the Giants lost 4–2. However, that was the Giants' only loss of the series, as they defeated Texas in five games and won their first World Series since 1954.