On 5 February 2020, López returned to the Italian top division, signing with second-from-bottom Brescia Calcio following Eugenio Corini's sacking. His contract with the club – also owned by Cellino – was terminated by mutual consent on 12 August following relegation, and Luigi Delneri succeeded him. On 6 October, however, he returned to the "Stadio Mario Rigamonti". He was shown the door again on 7 December, after a run of three defeats.