Although Sissoko did not belong to the governing party, Sudanese Union – African Democratic Rally, she was selected as Secretary of State for Social Affairs after the 1968 Malian coup d'état, making her Mali's first female member of government. She held this position until 1972, when the management of social affairs was taken over by the Ministry of Health. Beginning in 1985, she worked as an advisor for the Ministry of Labour and Civil Service ("ministère du Travail et de la Fonction publique").