After repeating as the national silver medalist, Uno finished fourth behind Patrick Chan, Jin Boyang and Yan Han at the 2016 Four Continents Championships, having ranked second to Jin in the short program and fifth in the free skate. At the 2016 World Championships in Boston, he placed 4th in the short program, 6th in the long, and 7th overall. At the 2016 Team Challenge Cup, Uno became the first skater to ever land a quadruple flip at an international competition. He landed two quads in his short program, 4F and 4T-3T combination, and scored a personal best of 105.74 points.