The town of Zabłudów was founded in 1553, it was also granted Magdeburg town rights. An annual fair and weekly market were established. It was a private town which in the late 16th century passed successively to the families of Pac, Sapieha, Leszczyński, Sanguszko, and from 1598 until the beginning of the 19th century it was owned by the Radziwiłł family. In the 17th century, there were guilds of tailors, shoemakers and potters; agriculture also developed. Also in the 17th century, Protestants, including the Polish Brethren, as well as Jews, settled in the town. In 1654, King John II Casimir Vasa confirmed Zabłudów's town rights and granted the coat of arms. In 1659 during the Russian-Polish War it was destroyed by invading Russian forces.