In May 2015, Godín was named as captain for Uruguay's defence of the Copa América during the 2015 continental tournament in Chile. He was also picked for the Copa América Centenario squad, heading home from a Carlos Sánchez long cross in the opener against Mexico where both teams ended with ten players (1–3 loss). He won his 100th cap in the following match, a 0–1 defeat to Venezuela at the Lincoln Financial Field.