After testing Indy Cars for multiple teams in 2000, Mears was offered a chance to drive a third entry for Team Rahal at California Speedway in October. After qualifying 15th and leading 10 laps, he posted a career-best fourth finish in his CART Series debut. He ran three IRL events at the start of the 2001 season and attempted to qualify for the 2001 Indianapolis 500, but ultimately did not make it. He ended the season by filling in for injured Champ Car driver Alex Zanardi, posting one top-10 finish in four starts.