In January 1619, William Spence along with John Fowler received a patent for 300 acres in Archer's Hope, a few miles from Jamestown. Since Spence continued to live at Jamestown Island, McCartney surmises that he placed indentured servants on the property along with his partner, John Fowler, who lived there. Fowler and four others, not including Spence or his wife, were killed in the Indian massacre of 1622 at Spence's house at Archer's Hope. A list of Virginia land patents sent to England in 1625 included 300 acres in Archer's Hope in the name of William Spence.