As from the 2012–13 season De Sciglio was assigned the number 2 shirt, which he called "very important" as in the past it was worn "by great players like Mauro Tassotti and Cafu", adding that he hoped to "live up to their standards". Throughout the season, De Sciglio became a regular in the starting line-up thanks to a series of convincing performances. He made 33 appearances in the 2012–13 season, managing three assists in the process. He played as both a left back and right back, showing competence on either flank.