Danish Sait worked as a radio jockey for "Supari" on Fever 104 FM in 2013. On the channel, he made several prank calls and enacted an array of fictional roles including Asgar, Chacko, Nagesh and Nograj. He is also a stand-up comedian and is a part of the Bengaluru-based comedy group The Improv. Starting in 2014, he hosted several sports shows including Pro Kabaddi League and the Cricket World Cup in 2015 before hosting Neevu Bhale Khiladi, a reality television show on Star Suvarna. He made his film debut with the Kannada movie "Humble Politician Nograj" in 2018 and portrayed the titular character in the film in addition to co-writing the film with director Saad Khan. The film released to positive reviews with one critic stating that "Danish Sait never fails to draw the audience, irrespective of where and how he plans to entertain. What is appealing is that he remains true to the character of Nograj ". In 2020, he starred in the Hindi-language web series "Afsos" as a tourist in Mumbai. That same year, he starred in the comedy "French Biriyani" as an auto driver along with Sal Yusuf, whom he worked with in "The Improv". In the film, he reprised the role of Asgar from his prank calls. He is set to star in "777 Charlie" alongside Rakshit Shetty.