Pyrrhus and his campaign in Italy was effectively the only chance for Greece to check the advance of Rome towards domination of the Mediterranean world. Rather than banding together, the various Hellenistic powers continued to quarrel among themselves, sapping the financial and military strength of Greece and to a lesser extent, Macedon and the greater Hellenistic world. By 197 BC, Macedonia and many southern Greek city-states became Roman client states; in 188 BC, the Seleucid Empire was forced to cede most of Asia Minor to Rome's ally Pergamon (Pergamum). Rome inherited that state, and most of Asia Minor in 133 BC. Total Roman domination over Greece proper was marked by the destruction of Corinth in 146 BC; Greece then formed an integral part of the Roman world leading into the Byzantine period.