Battery E, 1st Missouri Light Artillery Regiment was an artillery battery unit from Missouri that served in the Union Army during the American Civil War. The 1st Missouri Light Artillery Regiment formed on 1 September 1861. The battery participated in Frémont's expedition to Springfield in October 1861. This was followed by actions at Prairie Grove and Van Buren in December 1862. The following year, the battery fought at Cape Girardeau, Chalk Bluff, Vicksburg, the Expedition to Morganza, Brownsville, and Fort Esperanza. After performing garrison duty at Brownsville, Texas, the unit was mustered out in June 1864. For a few months at the end of 1864, a Pennsylvania battery took the name of this unit.