Following James's failure, attention turned to his son Charles, "the Young Pretender", who led the major uprising of 1745. With the failure of this second rebellion, the Stuart hopes of regaining the British throne were effectively destroyed. James and Charles later clashed repeatedly, and relations between them broke down completely when James played a role in the appointment of his son Henry as a cardinal. Henry then took holy orders, which required him to maintain celibacy, ending the possibility that he would produce a legitimate heir, infuriating Charles, who had not been consulted.