In August 2014, Brandreth was one of 200 public figures who were signatories to a letter to "The Guardian" opposing Scottish independence in the run-up to September's referendum on that issue. In May 2016, Brandreth told "The Spectator" that he was likely to vote for the UK to stay in the European Union in the following month's referendum on the issue. In 2019, Brandreth confirmed that he had voted to remain, but accepted the result of the referendum and believed that the government had to "get Brexit done".