Upon Cesare Prandelli taking the helm as national coach, Sirigu was named in his first squad list for the friendly against Ivory Coast. He made his international debut in that game losing 1–0, on 10 August 2010. On 3 September, on his second cap, he played his first competitive match, a 2–1 away win against Estonia for Euro 2012 qualifying. He was eventually selected to go to UEFA Euro 2012 as the third choice keeper of the Italian team, behind Gianluigi Buffon and Morgan De Sanctis; he did not feature in the tournament as Italy reached the final.