The brigade remained at Vicksburg until about the first of May, when General Pemberton decided to meet the enemy in the field. Toward the end of this campaign, on May 17, while guarding a bridge over the Big Black River, Vaughn's Brigade was overwhelmed by a Federal division at the Battle of Big Black River Bridge. The 60th regiment surrendered to Brigadier General Stephen G. Burbridge's 1st Brigade, 10th Division. A regimental report stated: "Lieutenant Colonel Gregg, one captain, three 1st lieutenants, seven 2nd lieutenants, six brevet 2nd lieutenants, captured at Big Black, Mississippi on May 17, 1863, and have not been exchanged. Enlisted men captured at Big Black: 239. They belonged to Companies "A", "B", "C", "D", "E" "F", "H" and "I". This report was dated October, 1864. The Federal reports of this action stated that the regiment, with 360 stand of arms, was captured without the loss of a man by the Federal troops. What was left of the regiment fell back into Vicksburg, and remained in the trenches until the surrender on July 4, 1863. The brigade was surrendered as part of Major General Morgan Lewis Smith's Division, and paroled a few days after the surrender.