On 8 December 1941, the Japanese attacked Hong Kong, and the school building was again taken over by the British Military, this time as a relief hospital. After the surrender of Hong Kong on Christmas Day 1941, the Japanese took over the school building.In December 1941 the school's operations was suspended until September 1946, and In February 1942, the Brothers were expelled from the college. During the Japanese occupation, the college was believed to have been used as a Number One Japanese military hospital (out of four in Kowloon) until August 1945.