Mahut reached the 2010 Wimbledon Singles Championship via the qualifiers, during which he beat Alex Bogdanovic in a marathon match, winning 6–3, 3–6, 24–22. A week later, he was beaten in the first round of the championship proper by John Isner in the longest match in tennis history (see below), Isner winning 6–4, 3–6, 6–7, 7–6, 70–68. Mahut also reached the qualifiers for the 2010 US Open, but lost to Julio Silva in the third qualifying round.