The division was activated in September 1917 at Camp Sherman, Ohio, and went overseas in June 1918. It was designated as the 2nd Depot Division. Thus it supplied over 195,000 officers and enlisted men as replacements in France without seeing action as a complete formation. Certain division units saw action, such as the 332nd Infantry Regiment, in Italy (Battle of Vittorio Veneto). Its commanders were Maj. Gen. Edwin F. Glenn (25 August 1917), Brig. Gen. Frederick Perkins (13 January 1918), Brig. Gen. Willard A. Holbrook (23 March 1918), and finally Maj. Gen. Edwin F. Glenn (3 April 1918). It was demobilized in October 1919.