The Penske years saw de Ferran finally fulfill the promise of the earlier part of his career with two CART titles and an Indy 500 victory. His analytical approach earned him comparisons with Penske's first driver, Mark Donohue. He also garnered praise for his politeness and integrity: when Penske switched to the Indy Racing League in 2002, he did not criticize the move even though it meant he could not defend his CART title. In 2003, de Ferran was injured during a race at Phoenix, suffering a broken back. Despite the injury, de Ferran passed his teammate, Castroneves with 31 laps left to win an emotional victory at the 2003 Indianapolis 500. It also was the second 1-2 finish for Penske Racing in the Indianapolis 500.