Clarke's most notable appearance at the Ryder Cup was in 2006, six weeks after the death of his wife Heather. Heather had loved the Ryder Cup and encouraged Darren to compete in it, so he made himself available for selection. European captain Ian Woosnam chose Clarke as one of his two wild cards, and he contributed three points from three matches to Europe's victory, and was embraced by members of the European and U.S. teams after he finished the tournament.