The reorganized regiment was sent south to Louisiana to resist Major General Banks, and fought in many minor engagements, including Cross Landing, Greenfield, Plum's Store, and with the First Alabama and Thirteenth Mississippi, engaged at Keller's Lane a largely superior force, which they routed, taking many prisoners and valuable stores. The regiment was called into the fortifications of Port Hudson, when attacked by the army and navy of the United States. The unit fought at Plains Store, the first engagement of the siege. Captain Reed, of Company G, was killed on May 29, 1863; Captain Hubbard, of Company D, was also killed. Within a day or two, Captain Stevenson died from wounds received. Capt. E. Wilson died from concussion of the brain, caused by being struck with a shell. This regiment sustained the highest number of casualties of any unit defending the post, eighty-one percent. The regiment started the siege of Port Hudson with 484 men, and came out with only 92.