"Spence" sortied with TG 58.4, the fast carriers, on 6 June, to attack the Mariana Islands. As aircraft struck the islands, the destroyer moved in and bombarded Japanese positions on Guam and Saipan. The planes attacked Iwo Jima on the 16th and then returned to shell the Marianas. Spence participated in the "Marianas Turkey Shoot" during the Battle of the Philippine Sea on 19 and 20 June. On 23 and 24 June, aircraft bombed targets on Guam, Saipan and Tinian. The destroyer conducted shore bombardment against Rota, Saipan and Guam from 26 June through the end of the month setting fuel tanks afire and sinking two sampans on the 27th. "Spence" replenished at Eniwetok in July and, on 4 August, sailed for the California coast via Pearl Harbor and arrived at San Francisco on 18 August. She was drydocked all of September and, on 5 October, sailed for Pearl Harbor and the Marshalls. She arrived at Eniwetok on 31 October and was ordered to Ulithi in early November, where she was assigned to TG 38.1, the Support Unit for the fast carriers of TF 38. She screened the carriers in Philippine waters as they launched attacks against Luzon during November and the first part of December.