Domenghini was capped on 33 occasions for Italy, scoring 8 goals for his country between 1963 and 1972. He represented Italy at UEFA Euro 1968 on home soil, and in the European Championship final, he notably scored the equaliser in the 80th minute against Yugoslavia from a powerful free-kick, after Italy had been trailing 1–0; this was Italy's first goal in a European Championship. Italy then went on to win the replay 2–0, which allowed them to win their first ever European Championship title; Domenghini was later named to the Team of the Tournament for his performances.