Patrick began racing stock cars in 2010 in the NASCAR Nationwide Series (now Xfinity Series) with her best result coming in the form of a fourth-place finish at Las Vegas Motor Speedway in 2011. She placed a career-high tenth in the 2012 season standings and was the second woman to clinch a pole position in the Nationwide Series after Shawna Robinson in 1994. Patrick started in the Sprint Cup Series (now NASCAR Cup Series) in 2012. She became the first woman to win a Cup Series pole position by setting the fastest qualifying lap for the 2013 Daytona 500, finishing eighth. Patrick bested Janet Guthrie's record for the most top-ten finishes by a woman in the Sprint Cup Series in 2015. She stopped racing full-time after the 2017 season, but competed at the 2018 Daytona 500 and the 2018 Indianapolis 500 before officially retiring.