Gené got his big break in 1999, occupying a race seat with the Minardi team. It was a difficult year; however, after several ninth places and an eighth, he managed to score his first point, and Minardi's first since 1995, with a sixth place at the European Grand Prix, while his team-mate Luca Badoer broke down in tears after his car's gearbox failed and denied the Italian his first points finish in Formula One, as he was running in fourth place with 13 laps to go. Gené continued with Minardi in 2000, but failed to score a single point, with his best finish being eighth at the Australian and Austrian Grands Prix. His team-mate in 2000 was Argentina's Gastón Mazzacane, who also achieved a best finish of eighth, at the European Grand Prix.