In January 2008 Sissoko transferred to Italian club Juventus, where he would team up with former coach Claudio Ranieri, for a fee of €11 million. He made his first appearance for the club in February 2008, coming in as a 67th minute substitution for Tiago in a Serie A fixture versus Cagliari Calcio. Sissoko scored his first goal for Juventus on 2 March 2008, the equaliser against Fiorentina. During the first half of the 2008–09 season, he regularly featured in the starting line-up, forming a partnership with youngster Claudio Marchisio as the centre midfield pair in Claudio Ranieri's 4–4–2 formation. His season ended early after he broke his foot in March 2009 ruling him out for the rest of that season and into the start of the 2009–10 season.