Following the departure of Rubinho in 2016, Audero was promoted to the club's third-choice goalkeeper behind Gianluigi Buffon and Neto for the 2016–17 season. After 61 call-ups in the league, Audero made his professional debut with Juventus on 27 May 2017, at the age of 20, in the final match of the 2016–17 Serie A season, a 2–1 away victory over Bologna.