Price made his major league debut with the Tampa Bay Rays on September 14, 2008, against the Yankees. The first MLB hit he allowed was a home run by New York Yankees shortstop Derek Jeter; Jeter would later record his 3,000th hit by again homering off Price in 2011. Price pitched innings of relief; he made his first major league start with the Rays on September 22, 2008, against the Baltimore Orioles. He was the winning pitcher in Game 2 of the 2008 ALCS against the Boston Red Sox, earning a postseason victory before winning a regular-season game. Price recorded the final four outs in Game 7 of the 2008 ALCS, earning his first career save (regular season or postseason; postseason statistics are recorded separately) and eliminating the defending champion Red Sox. Price then pitched innings in Game 2 of the 2008 World Series against the Philadelphia Phillies; he gave up two earned runs but nevertheless earned his second postseason save. The next day, Price introduced Barack Obama at a campaign rally in Tampa.