He qualified on pole position for the Spanish Grand Prix. With this pole position he took the record for youngest ever polesitter in the MotoGP class, a record previously held by Marc Márquez since 2013. He also qualified on pole position in Catalunya (ultimately finishing the race in second place) and the following race in Assen, setting a new lap record and becoming the youngest rider with consecutive pole positions in MotoGP history. He finished third in Assen, behind Maverick Viñales and Marc Márquez. The next race at the Sachsenring, he qualified second, behind Marc Márquez. During the second lap of the race Quartararo slumped in the third corner while sitting on the inside with Danilo Petrucci. He ended up in the gravel. This crash was the first crash during a race in his rookie season in MotoGP. Quartararo achieved further podium finishes on the season with a third place in Austria and four second place finishes in San Marino, Thailand, Japan, and Valencia. He started from pole position in Thailand, Malaysia, and Valencia. Quartararo ultimately finished the season in 5th place of the riders' standings with 192 points, 7 podiums, and 6 pole positions.