In 2016, Meili placed second in the 100-meter breaststroke at the US Olympic Trials and qualified for the US Olympic team for the 2016 Summer Olympics in Rio de Janeiro, Brazil. At the Olympics, she touched third in the 100-meter breaststroke behind Lilly King and Yuliya Yefimova, earning her the bronze medal. She also swam the breaststroke leg of the 4 × 100-meter medley relay in the preliminary heats, splitting a quick 1:04.93, to help the US qualify for the final. She earned a gold medal when the US team won in the finals.