He was overlooked for the Ireland match day squad to play Italy in the tournament's opening game, however, despite his form. He was again excluded from the squad the following week when Ireland were narrowly defeated by France in Paris, however on 19 February 2008 Bowe was named in the starting team at for the visit of Scotland to Croke Park, a match in which he scored two tries. He then played in the losses to Wales and England. On 4 February Bowe came on for Keith Earls as a replacement in the 2017 Six Nations Championship against Scotland national rugby union team.