On 5 July 2021, he was selected as the next Prime Minister of Haiti by President Jovenel Moïse, but two days later Moïse was assassinated, stalling the transfer of power. At the time, incumbent Prime Minister Claude Joseph took control of the government, with the backing of the military and was acknowledged by the United States as the rightful prime minister. On 19 July 2021, Joseph announced that he will stand down as prime minister in favour of Henry. Henry was sworn-in as the prime minister on 20 July.