In 2006, she landed a recurring role as Barb, opposite Julia Louis-Dreyfus, on the sitcom "The New Adventures of Old Christine"; she became a series regular during the series' third season in 2008. She also guest starred in the "Will &amp; Grace" episode "Buy, Buy Baby" in 2006. She provided voices for the 2006 films "Over the Hedge", "Barnyard", and "Brother Bear 2". She had a part in "My Super Ex-Girlfriend" and after playing in "Evan Almighty", had a bit part in "License to Wed". Sykes's first HBO Comedy Special, entitled "Wanda Sykes: Sick &amp; Tired", premiered on October 14, 2006; it was nominated for a 2007 Emmy Award. In 2008, she performed as part of Cyndi Lauper's True Colors Tour for LGBT rights.