During this century, the Ottoman Empire was expanding mightily in southeastern Europe. It completed the absorption of the Byzantine Empire in 1453 under Sultan Mehmet II by conquering Constantinople and Galata. It seized Genoa's last bastions in the Black Sea in 1475 and Venice's Greek colony of Euboea in 1479. Turkish troops invaded the Friuli region in northeastern Italy in 1479 and again in 1499–1503. The Apulian harbor town of Otranto, located about 100 kilometers southeast of Brindisi, was seized in 1480 (Ottoman invasion of Otranto), but the Turks were routed there in 1481 by an alliance of several Italian city-states, Hungary and France led by the prince Alphonso II of Naples, when Mehmet died and a war for his succession broke out. Cem Sultan, pretender to the Ottoman throne, was defeated despite being supported by the pope; he fled with his family to the Kingdom of Naples, where his male descendants were bestowed with the title of Principe de Sayd by the Pope in 1492. They lived in Naples until the 17th century and in Sicily until 1668 before relocating to Malta.