At the LPGA Playoffs at the ADT, the last event of the 2008 season, Creamer was hospitalized with a stomach ailment, which was originally thought to be peritonitis. The ailment continued to affect her in the opening few months of the 2009 season, with doctors unable to make an exact diagnosis. At the 2009 U.S. Women's Open, held at Saucon Valley Country Club, Creamer finished tied for sixth. In her third Solheim Cup, she was 3–1 as the U.S. again won the competition. Creamer finished 10th on the 2009 LPGA money list with earnings of over $1.1 million. Her highest finishes during the season were a pair of second-place results, at the LPGA Corning Classic and Lorena Ochoa Invitational.