In January 1943, the destroyer escorted a convoy from England to Cape Town, then made for Victoria, Australia for refit. After work was completed, "Quiberon" was assigned to the British Eastern Fleet, primarily as a convoy escort across the Indian Ocean. In July 1943, the ship rescued survivors from , that was sunk by U-boat "U-177". In April 1944, the destroyer was part of the carrier escort screen during Operation Cockpit, then again in May for Operation Transom: air raids against Japanese forces occupying the Dutch East Indies. After a brief refit in Melbourne, "Quiberon" resumed operations with the Eastern Fleet in August. In October, she took part in a series of fleet bombardments of the Japanese-held Nicobar Islands. In mid December, "Quiberon" was reassigned to Australian waters as a convoy escort and anti-submarine patrol vessel. During early 1945, the destroyer was attached to the British Pacific Fleet. Operating from Manus Island, "Quiberon" took part in operations in support of the American seizure of Okinawa and attacks on the Japanese home islands.