At the start of 1942, "Nizam" and her sister ship, sailed for Singapore to join as escort for the aircraft carrier . In June, the N class ships joined the escort of a large convoy to Malta, during which "Nestor" was sunk by aircraft. "Nizam" and her sisters were assigned to the Madagascar Campaign during September. On 22 September, "Nizam" was assigned to Durban to patrol for Vichy French merchant ships, capturing one and forcing another to scuttle during the week spent in this role. The destroyer then sailed to Simon's Town in South Africa for a refit, which lasted until the end of the year.