XEFO-AM signed on January 1, 1931, as the radio station of the National Revolutionary Party (later the PRI). In 1941, the PRN sold the station to Francisco Aguirre Jiménez. From 1030 AM he would build a broadcasting empire initially known as "Cadena Radio Continental", starting with XERC-AM in 1946 and growing into today's Grupo Radio Centro. That same year, the station took on the name "Radio Centro", branding as "the station of the Mexican family" and positioned itself as a general station similar to XEW-AM; while airing musical programming for most of its existence, in the 1980s, information and entertainment programs were added, and by 1998 non-talk programming had disappeared. Newscasts and sport programs were also present, but were later moved to Radio Red AM and Radio Red FM. Lately, the station aired programs focused on self-help and motivation, hosted by professionals in the topic, and it also aired the live Sunday noon mass from the Mexico City Metropolitan Cathedral (this broadcast was moved to XEN-AM and was also relocated to the Basilica of Our Lady of Guadalupe after the cathedral was damaged by the 2017 Puebla earthquake).