In the mid to late 3rd century, the army was afflicted by a combination of military disasters and of pestilence, the so-called Crisis of the Third Century. In 251–271, Gaul, the Alpine regions and Italy, the Balkans and the East were simultaneously overrun by Alamanni, Sarmatians, Goths and Persians respectively. At the same time, the Roman army was struggling with the effects of a devastating pandemic, probably of smallpox: the Plague of Cyprian, which began in 251 and was still raging in 270, when it claimed the life of emperor Claudius II Gothicus. The evidence for an earlier pandemic, the Antonine Plague (also smallpox) indicates a mortality of 15–30% in the empire as a whole. The armies would likely have suffered deaths at the top end of the range, due to their close concentration of individuals and frequent movements across the empire. This probably led to a steep decline in military numbers, which only recovered at the end of the century under Diocletian (r. 284–305).