On May 11, 2000, Griese entered the Bundestag as a successor for the departed MP Willfried Penner. In the 2002 general election, she was elected directly with 45.3% of the first votes for the federal constituency Mettmann II (Heiligenhaus, Ratingen, Velbert and Wülfrath). In 2005, she was re-elected with 43.5% of the first votes. In 2009, she only received 35.6% of the first votes and was not elected. On July 23, 2010, she reentered the Bundestag after Angelica Schwall-Düren was appointed State Minister for Federal Affairs, Europe and Media in the state government of North Rhine-Westphalia. In the 2013 general election, she received 37.1%, and in 2017, 30.6% of the first votes. In each case, she entered the parliament via the SPD state list.