On 12 March 1560, the Holy League captured the island of Djerba, which had a strategic location and could control the sea routes between Algiers and Tripoli. As a response, Suleiman sent an Ottoman fleet of 120 ships under the command of Piyale Pasha, which arrived at Djerba on 9 May 1560. The battle lasted until 14 May 1560, and the forces of Piyale Pasha and Turgut Reis (who joined Piyale Pasha on the third day of the battle) won an overwhelming victory at the Battle of Djerba. The Holy League lost 60 ships (30 galleys) and 20,000 men, and Giovanni Andrea Doria was barely able to escape with a small vessel. The Ottomans retook the Fortress of Djerba, whose Spanish commander, D. Álvaro de Sande, attempted to escape with a ship but was followed and eventually captured by Turgut Reis. In 1565 the Ottomans sent a large expedition to Malta, which laid siege to several forts on the island, taking some of them. The Spanish sent a relief force, which finally drove the Ottoman army out of the island.