Sophia spent the rest of her life as a member of Athenian high society and sponsor of charitable endeavors. In 1902, after witnessing the sufferings of Greek soldiers of the recent war with Turkey, she and a group of society ladies sponsored the construction of a sanatorium for tuberculosis sufferers in Goudi. She served on its board of directors from 1919 until her death in 1932. The institution has since become the Sotiria Thoracic Disease Hospital, the largest pulmonary center in Greece.