In the 2019 FIFA Women's World Cup qualification – UEFA play-offs Miedema scored twice against Switzerland, taking her country to the World Cup finals in France, where she scored three times. On 15 June 2019, Miedema became the all-time top scorer of the Netherlands women's national football team after scoring her 60th goal in a 3–1 Group E win against Cameroon. She passed the record held by Manon Melis and extended her lead over the men's team's leading scorer, Robin van Persie, who scored 50 goals before retiring. In the quarter-final against Italy she scored the first goal of the match, helping the Dutch progress. In the final against the United States the Netherlands did not score and lost 2–0. At the 2020 Olympics in Tokyo Miedema broke the record of most goals scored in a single Olympic tournament: 10. In 100 appearances for the senior national team as of July 2021, Miedema has scored 83 goals. None of her goals have come from penalty kicks. She has scored five hat-tricks; against Portugal (2013 and 2014), Greece (2013), Russia (2017), and Zambia (2021), when she scored four goals. Her most productive year was 2017 with 20 goals from 21 games.