Mkhitaryan played three games for Arsenal before, on 2 September 2019, he joined Italian club A.S. Roma on a season-long loan deal for €3 million, plus an additional €100,000 in variables. Mkhitaryan made his debut against Sassuolo on 15 September and scored a goal in Roma's 4–2 win. In late September, Mkhitaryan suffered an injury to his adductor muscle in a 1–0 win over Lecce. Initially expected to be out for three weeks, he returned to the squad in late November. On his first game back from injury, Mkhitaryan scored in a 3–1 win over Hellas Verona. He then scored two games later against SPAL on 12 December 2019, sending Roma up to fourth place in the Serie A table.