War with France had broken out while "Bolton" was at Africa on her first voyage. Captain Roger Lee acquired a letter of marque on 23 October 1793. "Bolton" sailed from Liverpool on 17 November. "Bolton" arrived at Kingston, Jamaica on 17 April 1794. She had embarked 432 slaves and she arrived with 431, having suffered only one slave death on the Middle Passage. She arrived back at Liverpool on 16 September 1794. She had left Liverpool with 49 crew members and she suffered eight crew deaths on the voyage.