During her first World Cup season, Neuner only appeared in ten races, finishing 34th in the overall standings. In the 2006–07 season, she became a regular in the German team and ended the season in fourth place. Neuner won the Biathlon World Cup for the first time in 2007–08; she also won the sprint and mass start disciplines. She finished the 2008–09 season fourth, winning the individual discipline that year. In the 2009–10 season, Neuner won the overall World Cup for a second time; by winning the pursuit and mass start scores as well, she has claimed each World Cup title at least once. In 2010–11, she won the sprint discipline for a second time and finished fifth in the season ranking. In her final World Cup season in 2011–12, Neuner won her third Overall World Cup title, as well as the sprint discipline.