For the 1988 season he was signed by the Osella Formula One team, and drew good notices for his valiant performances in the hugely uncompetitive car, with a best result of 9th in the Monaco Grand Prix. He would continue with Osella in the 1989 season, their much-improved car suffering from the lottery of pre-qualifying. However, Larini continued to shine, running 6th at the San Marino Grand Prix until a hub failure, and running third at the Canadian Grand Prix until an electrical failure. He would also qualify 10th for the Japanese Grand Prix.