Nicomedes IV's brother, Socrates Chrestus, assisted by Mithridates VI, defeated Nicomedes IV's army in 90 BC, and Nicomedes IV was forced to flee to Italy. He was restored to his throne by Manius Aquillius due to Rome's influence in the region. However, Aquillius encouraged Nicomedes IV to raid Mithridates VI's territory, prompting Mithridates VI to retaliate again in 88 BC. Nicomedes IV fled once again to Rome. Mithridates invaded and conquered Bithynia and the Roman provinces of Asia starting the First Mithridatic War.