Grande performed "Side to Side" for the first time in "Vevo Presents" show in May 2016. Later, she performed at the 2016 MTV Video Music Awards with Minaj. Stationary bicycles and a pommel horse were featured as props in the performance. Grande also performed the song on "The Tonight Show Starring Jimmy Fallon" on September 8, 2016. Additionally, she performed the single in an acoustic medley with "Into You" on "The Ellen DeGeneres Show" on September 14, 2016. On September 24, 2016, she performed the song at the 2016 iHeartRadio Music Festival on The CW. On November 20, 2016, Grande and Minaj performed "Side to Side" at the 2016 American Music Awards. It was named the best performance of the night by editor Andrew Unterberger from "Billboard". On June 4, 2017, the song was part of Grande's set list for "One Love Manchester", a benefit concert for the victims of the Manchester Arena bombing. Minaj has performed the song on the setlist of her 2019 Europe tour, The Nicki Wrld Tour. Similarly, Grande has performed the song on her Sweetener World Tour and at Coachella Valley Music and Arts Festival, along with Minaj at the latter.