In May 2019, Marquinhos was included in Brazil's 23-man squad for the 2019 Copa América on home soil. In the semi-finals against Argentina on 2 July, Marquinhos was tasked with marking Lionel Messi while suffering from diarrhea. He helped Brazil to a 2–0 victory over their rivals; he came off in second half for Miranda. On 7 July, Marquinhos started in Brazil's 3–1 win over Peru in the final at the Maracanã Stadium.