Spanoulis' retirement from the senior Greek national basketball team was announced on September 17, 2015, after the 2015 EuroBasket. He ended his senior men's Greek national basketball team career, having been the leading scorer in every major tournament that he played in, from 2006 onward (9 tournaments in total: 2006 FIBA World Cup, 2007 EuroBasket, 2008 FIBA World Olympic Qualifying Tournament, 2008 Summer Olympics, 2009 EuroBasket, 2010 FIBA World Cup, 2012 FIBA World Olympic Qualifying Tournament, 2013 EuroBasket, and the 2015 EuroBasket).