In the 2010 season he competed at the World Indoor Championships for the first time. He was a 400 m semifinalist but an injury to Ayre in the relay meant the Jamaican relay team did not finish. He improved his personal best to 44.54 seconds with a run at the Herculis meeting in Monaco, finishing second behind compatriot Jermaine Gonzales. He was selected to represent the Americas team over 400 m at the 2010 IAAF Continental Cup and he won his first medal at a global competition. He ran near his personal best, recording 44.59 seconds, to take the silver medal behind his teammate Jeremy Wariner. He closed the competition by running the anchor leg of the relay for the Americas team which won in a championship record of 2:59.00, breaking the USA's 29-year-old mark.