For the majority of the war, the 50th Georgia served with the First Corps of the Army of Northern Virginia. The regiment participated in more than 45 engagements during the war. Some of the early battles in the East that the regiment took part in included South Mountain, Sharpsburg, Chancellorsville, and Gettysburg. The regiment went south when James Longstreet took his corps to Georgia and Tennessee in the fall of 1863, where it was engaged at the Siege of Knoxville. Returning to Virginia, the 50th Georgia fought in the Siege of Petersburg, the Battle of Cedar Creek, and the Battle of Sayler's Creek.