At the outbreak of hostilities between Kingdom of Italy and the Austrian Empire in 1915 the Cremona along with the "Friuli" Brigade formed the 16th Division of the Line. For next years the brigade was on the Isonzo front and participated in the twelve Battles of the Isonzo. After the Italian Army's collapse after the Twelfth Battle of the Isonzo the brigade managed to retreat to the Piave front, but had to absorb the remnants of the "Tortona" Brigade to compensate for the heavy losses it had suffered. In 1918 the brigade fought in the second and third Battles of Monte Grappa.