Humphrey was born in a room over his father's drugstore in Wallace, South Dakota. He was the son of Ragnild Kristine Sannes (1883–1973), a Norwegian immigrant, and Hubert Horatio Humphrey Sr. (1882–1949). Humphrey spent most of his youth in Doland, South Dakota, on the Dakota prairie; the town's population was about 600. His father was a licensed pharmacist and merchant who served as mayor and a town council member. The father also served briefly in the South Dakota state legislature and was a South Dakota delegate to the 1944 and 1948 Democratic National Conventions. In the late 1920s, a severe economic downturn hit Doland; both banks in the town closed and Humphrey's father struggled to keep his store open.