On 6 January 2014, Rami made his debut in Serie A, coming on as a substitute for Cristián Zapata in a match against Atalanta, a 3–0 win. On 1 February, he scored his first goal in Serie A, against Torino. On 23 February, he scored his second goal against Sampdoria. His third and last goal of the Serie A season came on 16 March, against Parma.