Wecht became famous appearing on television and consulting on deaths with a high media profile. Some of the cases include; Robert F. Kennedy, Sharon Tate, Brian Jones, the Symbionese Liberation Army shootout, John F. Kennedy, the Legionnaires' Disease outbreak, Elvis Presley, Kurt Cobain, JonBenét Ramsey, Dr. Herman Tarnower (the Scarsdale diet guru), Danielle van Dam, Sunny von Bülow, the Branch Davidian incident, Vincent Foster, Laci Peterson, Daniel and Anna Nicole Smith, and Rebecca Zahau. During his career, Wecht performed more than 14,000 autopsies. He is a clinical professor at the University of Pittsburgh School of Medicine and an adjunct professor of law at Duquesne University.