On 28 May 2015, Di María was named in Argentina's squad for the 2015 Copa América. On 6 June, he was selected to captain the team in the absence of Lionel Messi for a warm-up match against Bolivia, scoring twice in a 5–0 win. A week later, in their opening match of the tournament against Paraguay in La Serena, Di María won a penalty which Messi scored in a 2–2 draw. On 30 June, he scored twice and assisted a goal for Sergio Agüero, as Argentina defeated Paraguay 6–1 to reach the final. He was substituted with a hamstring injury within the first half-hour of the final against hosts Chile, which his team lost in a penalty shootout after a goalless draw.