In 184, Han Sui and his colleague Bian Zhang joined Beigong Boyu in the Liang Province rebellion. Together they attacked Chang'an in 185 and 188/189. After their first failure to take Chang'an, Han Sui killed Beigong Boyu and seized command himself with Wang Guo as a figurehead. They failed to take Chang'an again in 189. Wang Guo was deposed and the rebel forces split up into three groups: Han Sui in Jincheng Commandery, Ma Teng in Longxi Commandery, and Song Jian on the upper Yellow River. He initially supported Dong Zhuo and his successor Li Jue, but turned on them in 194 when he joined Ma Teng in attacking Chang'an. They were defeated at Changping Slope northwest of Chang'an and Han Sui was forced to withdraw to Youfufeng Commandery. Han Sui fell out with Ma Teng, possibly due to the machinations of Cao Cao's agent Zhong Yao, and they began to skirmish with Ma Teng taking the heavier losses, causing him to join Cao Cao. In 210 Han Sui defeated Zhang Meng in Wuwei Commandery. In 211 Cao Cao sent troops against Zhang Lu. Believing that this was a preliminary attack on themselves, Han Sui and Ma Chao forged an alliance and confronted the enemy troops with initial success, driving them away. Later, Cao Cao personally led an army against the western alliance. When the three armies met at Huayin, Han Sui attempted to negotiate with Cao Cao and talked of the old days when they were friends at Luoyang, but Cao Cao's replies were mixed. The two sides agreed on a day to do battle. Han Sui and Ma Chao were defeated and forced to retreat. In 214 Xiahou Yuan drove Han Sui from Hanyang Commandery. Han Sui's officer Yan Xing rebelled against him and defected to Cao Cao. Han Sui died in 215 at the age of 70.