In the spring of 2011, several major tornado outbreaks affected the Central and Southern United States. Forty-three people were killed in a tornado outbreak from April 14–16. Approximately 350+ people were killed in a tornado outbreak from April 25–28, the deadliest U.S. tornado outbreak in 75 years (since the 1936 Tupelo-Gainesville tornado outbreak). States particularly hit hard by the outbreaks included Oklahoma, Arkansas, Mississippi, Tennessee, Georgia, North Carolina, Virginia, and most especially, Alabama, which sustained over 250 fatalities alone. The latter outbreak produced $10 billion in damage, making it the costliest tornado outbreak in history. On May 22, an EF5 tornado devastated Joplin, Missouri, killing 154, injuring over 1,000 people, and causing $1–3 billion in damage, making it the deadliest single U.S. tornado in 64 years and the costliest single tornado of all time.