Listed are fatalities of riders in the World Grand Prix Motorcycle Racing Championship races since its foundation in 1949. In total, 104 riders have died from incidents that occurred at a Grand Prix motorcycle racing event, with Ben Drinkwater being the first in 1949. Three riders died in the 1940s; twenty-nine in the 1950s; twenty-seven in the 1960s; twenty-four in the 1970s; fourteen in the 1980s; two in the 1990s; one in the 2000s; three in the 2010s; and one in the 2020s. The most recent fatal accident occurred in May 2021 when Jason Dupasquier was killed after a crash during qualifying at the Italian Grand Prix, while the most recent fatal accident to occur in the 500cc/MotoGP class happened in October 2011, when Marco Simoncelli was killed after he was struck by Valentino Rossi and Colin Edwards during the Malaysian Grand Prix.