Darmian's appearances in the league became limited after a 1–1 draw against rivals Liverpool on 15 January, with him not featuring again until 19 March when he came on as a stoppage time substitute in a 3–1 win against Middlesbrough. On 9 April, he started for United, his first in the league since January, in a 3–0 victory over Sunderland at the Stadium of Light. In May 2017, Darmian played in both of the UEFA Europa League semi-final games against Spanish-side Celta Vigo, helping United go through to the final 2–1 on aggregate. On 24 May, Darmian started at left-back in the UEFA Europa League Final against Dutch-side Ajax, playing the full 90 minutes as United won 2–0.