Born in Pedaso, in the Province of Fermo, Marche, De Angelis started his career at an amateur club in Comunanza, in the Province of Ascoli Piceno, Marche. He was signed by Serie C2 club Civitanovese in 1987, located in Province of Macerata, Marche. In 1989, he was signed by Ancona Calcio, located in Ancona, the capital of Marche region. He made his Serie B debut for the club. The club finished as the third of 1991–92 Serie B, thus promoted to Serie A. In November 1992 De Angelis was loaned to Barletta of Serie C1, after no appearances in 1992–93 Serie A. Ancona relegated back to Serie B in 1993, which De Angelis continued to play for the Marche club until 1995.