She beat four other actresses for one of the lead roles on ABC's "Desperate Housewives", in which she starred as Susan Mayer, a role for which she won the Golden Globe Award in January 2005. Later that year, Hatcher won the Screen Actors Guild (SAG) award in the same category. In July 2005, she was nominated for an Emmy award as Outstanding Lead Actress in a Comedy Series, along with co-stars Marcia Cross and Felicity Huffman.