In 2013, Layún received his first national team call up by coach José Manuel de la Torre after his performances with Club América during the Clausura tournament. He was selected for the 2013 CONCACAF Gold Cup held in the United States, with the entire squad being made up of players from the Mexican league. He made his debut on 11 July in the group stage match against Canada at CenturyLink Field in Seattle. He played the entire ninety minutes in Mexico's 2–0 victory. Mexico was eventually eliminated from the competition by Panama in the semi-finals.