In 2011, Wise returned to JR Motorsports part-time and also drove for Go Green Racing and Key Motorsports. Wise raced part-time in 2011 bouncing between three different teams but still managed to finish 16th in the Nationwide Series drivers standings, He also made his Cup Series debut at Chicago, driving for Max Q Motorsports; he qualified for three additional races over the rest of the year. In 2012, Wise ran the majority of the Nationwide Series schedule for The Motorsports Group. He also competed full-time, except for the Daytona 500, in the Sprint Cup Series, competing for rookie of the year, driving the Front Row Motorsports No. 26. Wise mostly ran the 26 as a start and park entry and finished behind Stephen Leicht in ROTY standings.