Known for playing with two hands on both sides, flat and quick groundstrokes, crafty gameplay, aggressive volleys, and unorthodox variety of shots, Hsieh is regarded as one of the most successful and versatile doubles players in history. She has won four Grand Slam titles in doubles, claiming the 2013 Wimbledon Championships and the 2014 French Open with Peng Shuai (with whom she also won the 2013 WTA Tour Championships), the 2019 Wimbledon Championships with Barbora Strýcová, and the 2021 Wimbledon Championships with Elise Mertens. Hsieh and Strýcová also were the runners-up at both the 2019 WTA Finals and the 2020 Australian Open. She also reached the quarterfinals in doubles at the 2012 London Olympics with compatriot Chuang Chia-jung. Though Hsieh has yet to win a Grand Slam on hard courts, most of her titles have come on hard courts, including seven of her Premier Mandatory/Premier 5 titles.