In November 2010, she announced a comeback, indicating her desire to race at the 2012 Summer Olympics. At the 2011 Pan American Championships, Hughes won the individual time trial and road race, both by a big margin. In May 2011, she took first in the Tour of the Gila, winning two stages. In July 2011, she finished first in the inaugural Crusher in the Tushar in Beaver, Utah. At the Chrono Gatineau time trials in May 2011, she finished first among an international slate of riders. In June 2012, she was selected to become part of Canada's 2012 London Olympics team, as one of four in cycling, with two other women and a man. She finished 32nd, with the peloton, in the road race and finished 5th in the road time trial at the 2012 Olympics.