The family moved to Osawatomie, Kansas, in 1859, but the frontier violence caused them to move to Missouri in 1860. Eventually, Daniel succeeded in curing Martha's disease. As the American Civil War neared, violence spread into Missouri during the Bleeding Kansas incidents. In October 1860 several men led by Duff Green demanded that Daniel Marshall provide medical assistance to the pro-slavery faction, but he refused, and the men left. When the Marshalls' neighbors warned that Green was planning to return and murder them, the family quickly packed their belongings and escaped by steamboat to Illinois. The Marshalls remained in Illinois only briefly, before relocating to Indiana, which was even farther from the volatile border region.