Reyes was beaten 6–4 by Andrew Davidson in the second round of the 2016 UK Open. At the fifth Players Championship event he reached the quarter-finals of a Pro Tour event for the first time and was edged out 6–5 by Robbie Green. A 6–2 win over Mensur Suljović saw him advance to the semi-finals of the 11th event, where he lost 6–4 to Joe Cullen. A win would have seen Reyes qualify for the World Matchplay. Two further quarter-finals did see him qualify for the World Grand Prix for the first time and his first round match went to a deciding leg, which Kyle Anderson won. A 6–4 win over Robert Thornton saw Reyes reach the second round of the European Championship for the second year in a row and he lost 10–7 to Peter Wright. Reyes closed out the major events of 2016 with a 6–5 loss to Berry van Peer in the opening round of the Players Championship Finals.