Fort Chambray saw its first use during the French invasion of Malta in June 1798. When the French landed on Gozo, many inhabitants took refuge within Chambray, bringing their livestock with them. At the time, the fort was commanded by the knight de Megrigny, and it was armed with 72 pieces of artillery. The fort initially offered some resistance, but it capitulated after the French General Jean Reynier posted three companies in front of the fort, and issued a proclamation ordering its garrison to surrender. The Gozitans who had taken refuge returned to their homes with their cattle.