Vrbno was founded probably in the 11th or 12th century in the area inhabited since the 5th millennium before Christ. Mentioned for the first time in 1241 it was the possession of the Queens of Bohemia who owned the castle of Mělník. Then in the 14th century it was enlarged by Queen Elisabeth of Bohemia, the wife of John of Bohemia, and divided between the Queen’s dominion of Mělník and the local noble family which sold its possession to the Knights of the Cross of the Red Star. This division remained unchanged till the Revolution of 1848, and then Vrbno became a municipality with three cadastral areas. In 1932 there lived 496 permanent residents. Because of the decreasing number of inhabitants, it was united with adjacent municipalities of Hořín and Brozánky in 1960. During the European floods in 2002 the whole village was flooded, many buildings seriously damaged, the third part of addresses destroyed. Nevertheless, the centre of Vrbno was put on the list of the Village Monuments Areas in 2004. For its untouched picturesque atmosphere Vrbno became a place where many movies were taken, e.g. about Jules Maigret and "Les Misérables".