Süle tore his anterior cruciate ligament in the twelfth minute of the team's eight league match of the season and was expected to be out of the line-up for eight to ten months, preventing him from participating with Germany for UEFA Euro 2020, before the tournament was postponed. On 8 August 2020, Süle played against Chelsea in the Champions League marking his first match since October 2019. He then started from bench in the later games in the Champions League. On 23 August 2020, Süle came on from the bench in the 2020 UEFA Champions League Final and replaced Jérôme Boateng after he suffered an early injury. He won the Champions League, completing the continental treble for that season.