When Liu Bei sought refuge with Liu Biao, he sent Mi Zhu first to meet and discuss with him. And for his effort in soothing the relation between them was appointed as General of the Left's Attending Official Internal Cadet. After Liu Bei conquered Yi Province (covering present-day Sichuan and Chongqing) in 214, Mi Zhu was promoted to General Who Pacifies Han (). Although he was not given any troops to command, as military manoeuver were not his expertise, he was nonetheless the most highly esteemed among Liu Bei's subjects. He was viewed as a role model official for the state of Shu and many young civil officials looked up to him as they did to Zhuge Liang, Fa Zheng, Dong He and Xu Jing.