Makrypoulia graduated from Vasilis Diamantopoulos' Drama School in 1994, while she has also attended acting classes at Theatro ton Allagon. Then she started appearing on television and has participated in various shows and commercials for the last 14 years. She also has worked in various television productions. Makrypoulia appeared in the hit series Para Pente, with her performance as a naive village girl in the series. Zeta and actor/scriptwriter Giorgos Kapoutzidis were commentators of the 51st Eurovision Song Contest in Athens.