Scirea made his Serie A debut for Atalanta against Cagliari on 24 September 1972. He remained with Atalanta for two seasons, before transferring to Juventus, with whom he would stay until the end of his playing career. In all he made 397 appearances in Serie A, scoring 24 goals. Scirea saw great success with Juventus, playing alongside Antonio Cabrini, and the hard-hitting Claudio Gentile, as well as goalkeeper Dino Zoff. He managed the impressive feat of winning every UEFA Club and domestic competition during his time at the club (seven Serie A titles, two Coppa Italias, one UEFA Cup, one Cup Winners' Cup, one European Cup, one UEFA Super Cup, and one Intercontinental Cup).