On 27 August 2010, Reyes opened the scoring in the 2–0 defeat of Inter Milan for the UEFA Super Cup, after a one-two combination with Argentine Sergio Agüero. His first league goal of the campaign came in a 1–4 defeat at Hércules CF on 10 January 2011, which inspired an impressive run of scoring form, with goals in successive home games in February/March, against Valencia CF, former club Sevilla and Villarreal.