On October 16, in the 2014 National League Championship Series, Panik hit a two-run home run in Game 5 to help lead the Giants to an eventual 6–3 victory over the Cardinals to advance to the 2014 World Series against the Royals. On October 29, in Game 7 of the World Series, the Giants beat the Kansas City Royals 3–2 to win the series. In the bottom of the third inning with a runner on first, Panik made a diving stop on a ball up the middle and flipped the ball with his glove to shortstop Brandon Crawford to get the lead runner out. Crawford then threw to first to try to get a sliding Eric Hosmer out. Initially, Hosmer was called safe on the play but after a three-minute replay review, the call was overturned for the 4–6–3 double play. It was the first ever overturned call in the World Series since the replay review system was implemented, and the double play was regarded by multiple sportswriters as one of the most spectacular plays in World Series history.