Raimundi-Ortiz's early work often examined pop, hip-hop and comic culture, depicting famous people (like Celia Cruz) or her own epic characters (like "Wepa Woman" and "Chuleta") in mural form. But her most notable work is multi-disciplinary or performance-based such as "RicanStruction" that was featured in Performa '05 Biennial creating a pop-up stereotypically Nuyorican beauty parlor. Another of her more interactive performance works was featured in "The Post Millennial Black Madonna," an exhibition at Museum of Contemporary African Diasporan Arts in 2007. In 2011 Raimundi-Ortiz performed her "Hush" series in New York City and at Gyeongnam Art Museum in South Korea. In response to the Pulse shooting, she held a calavera making workshop in Orlando that culminated in a Dia de los Muertos ofrenda. This shrine was exhibited in the National Museum of Mexican Art in Chicago in 2016. Raimundi-Ortiz had work in "Silos", an exhibition at American University in 2016. She was a 2016-17 recipient of a Franklin Furnace Fund. Raimundi-Ortiz is a professor at University of Central Florida.