In 2020, Duff portrayed Erin Wiley, the estranged heroin addict mother of established character Maeve in the second season of critically acclaimed Netflix original series "Sex Education". In June 2020, Duff appeared in a main role as Tracy Daszkiewicz in three-part drama "The Salisbury Poisonings". The series portrays the 2018 Novichok poisoning crisis in Salisbury, England, and the subsequent Amesbury poisonings.