The plague returned at intervals with varying virulence and mortality until the early 19th century. In England, for example, the plague returned in 1360–63, killing 20% of Londoners, and in 1369, killing 10–15%. At the end of the 16th century, the plague hit San Cristóbal de La Laguna (1582–83) in the Canary Islands. In the 17th century, outbreaks were a series of "great plagues": the Great Plague of Seville (1647–52), the Great Plague of London (1665–66) and the Great Plague of Vienna (1679). In its virulent form, after the Great Plague of Marseille in 1720–22, the Great Plague of 1738 (which hit Eastern Europe) and the Russian plague of 1770–1772, it seems to have gradually disappeared from Europe, though it lingered in Egypt and the Middle East. By the early 19th century, the threat of plague had diminished, but it was quickly replaced by a new disease, the Asiatic cholera, which was the first of several cholera pandemics to sweep through Asia and Europe during the 19th and 20th centuries.