On 15 August 2010, in the first Premier League match of the 2010–11 season, Rosický was brought on as a substitute when Arsenal were trailing by a goal to Liverpool at Anfield, producing a cross in the 89th minute that was diverted by Marouane Chamakh against the post. The ball then hit Liverpool goalkeeper Pepe Reina before crossing the line for the equalising goal as the game finished 1–1. He scored his only goal of the season in an FA Cup tie away to League One side Leyton Orient at Brisbane Road on 20 February 2011 with a 53rd-minute header, although the match finished in a 1–1 draw. On 27 February 2011, Rosický started the 2011 League Cup Final against Birmingham City at Wembley, playing the full 90 minutes as Arsenal were defeated 2–1. At the end of the campaign, Rosický had scored one goal and made 34 appearances in all competitions for the Gunners.