Amal Kassir was born and raised in Denver, the fourth of five children. Her name means "hope" in Arabic. She was born to Melissa, an Iowa-German convert to Islam living in Nebraska and Mahmoud Kassir, a Syrian. Her mom had converted to Islam as a teenager. They moved to Denver to join a growing Muslim community. She was passionate for human rights from a young age, as her mother recalled how once when Amal was four and they were cleaning the garage, the child climbed atop the pile of castoff items and began reciting the Pledge of Allegiance. "She thrust her finger in the air and shouted, 'And liberty and justice for all!'" Melissa Kassir recalled. As two years later the terrorist attack against the Twin Towers on the 11 September occurred, a person threw a brick-stone through the window of the family restaurant and Kassir was insulted for wearing a hijab. On her first day at the private school her parents sent her to, a teacher asked Amal which she liked better, America or Syria. When Amal replied "America," the teacher slapped her face. Her parents decided to move to Kassir grandmother's house in outskirts of the Syrian capital, Damascus. Amal Kassir lived in Syria for three years, learning Arabic and bonded with her “60-something cousins.” A decade later, Kassir grieved as 15 of those family members were killed during the Syrian civil war. After attending community college, Kassir graduated from the University of Colorado.