On 25 August 2011, following the UEFA European Under-21 Championship, Domínguez was called up to the senior national team by coach Vicente del Bosque for matches against Chile and Liechtenstein. Domínguez failed to feature in either match but made his debut on 26 May the following year, playing 45 minutes in a 2–0 friendly win over Serbia ahead of the 2012 European Championship. He featured again four days later in Spain's 4–1 win over South Korea but ultimately missed out on a place in the final tournament squad.