She made a breakthrough at senior level at a World Cup meeting in Val-d'Isère just before Christmas 2016: she took a seventh place in her first World Cup start in downhill, and took her first podium finish when she finished second in the combined. Later that season at the World Championships in St. Moritz, Gisin took a silver medal in the combined, finishing behind teammate Wendy Holdener in a one-two finish for the Swiss on home snow.