During the first half of the season, Henderson hit well, batting .298 with 18 home runs and 50 RBIs, and was selected for the 1991 All-Star Game with over 1.5 million fan votes. He started the All-Star Game for the AL in right field, and was 0-for-2 at the plate before being pinch hit for by Rubén Sierra in the sixth inning. In August, Henderson hit three home runs in a single game, in a losing effort against the Minnesota Twins, with all three coming in consecutive at bats off of starting pitcher David West. Henderson's average dipped in the second half of the season and he finished the year at .276 with 85 RBIs and a career-high 25 home runs. The Athletics finished with an 84–78 record, 4th place in the AL West.