Lozano was included in the provisional roster for the 2015 CONCACAF Gold Cup by Miguel Herrera but was cut from the final list, remaining in the Provisional List if someone else got injured. Lozano received his first call-up to the senior national team in February 2016 under coach Juan Carlos Osorio. On 10 February, Lozano earned his first cap as a starter in the friendly against Senegal, assisting fellow Pachuca teammate Rodolfo Pizarro in the second goal as Mexico won the match 2–0. The following month, Lozano scored his first international goal in the 39th minute of the 2018 FIFA World Cup qualifying third round match against Canada, which Mexico won 3–0. He was included in Mexico's 23-man squad to participate at the Copa América Centenario. He appeared in all matches of the tournament, culminating in a quarter-final exit.