Pruzzo passed to Roma in 1979, for the then record sum of 3 billions liras. Here he became famous as one of the most effective Italian strikers of the 1980s, winning one scudetto during the 1982–83 season, and four Italian Cups in 1980, 1981, 1983, and 1986. He also won the Serie A top scorer award three times, in 1981, 1982, and 1986, as well as the Coppa Italia top scorer award in 1980. He also scored a goal in the 1984 European Cup Final, when Roma, playing at home, was beaten on penalties by Liverpool.