In Week 1 against the Washington Redskins, Wentz finished with 307 passing yards, two touchdowns, and an interception from a pass tipped at the line of scrimmage as the Eagles won by a score of 30–17. In Week 2 against the Kansas City Chiefs, Wentz threw for 333 yards, two touchdowns, and one interception. In addition, he rushed for 55 yards in the 27–20 loss. In a Week 5 34–7 rout over the Arizona Cardinals, Wentz finished the game with 304 yards and a career-high four passing touchdowns. In the first five games of 2017, he passed for 1,362 yards and 10 touchdowns with three interceptions. After this start, NFL insiders and reports ranked Wentz as a possible NFL MVP. Wentz was named the NFC Offensive Player of the Week for Week 7 after passing for 268 yards and a career-high tying four touchdowns in a 34–24 win over the Redskins. During Week 9 against the Denver Broncos, Wentz finished with 199 passing yards and 4 touchdowns as the Eagles won 51–23. During Week 14 against the Los Angeles Rams, Wentz left the game due to an apparent knee injury. He finished with 291 passing yards, 4 touchdowns, and an interception as the Eagles won 43–35. The win earned Wentz's first NFC East Title in the Pederson/Wentz era. The next day, an MRI revealed that he suffered a torn ACL, keeping him out for the remainder of the season. In 13 starts, Wentz finished the year with 3,296 passing yards, 33 touchdowns, 7 interceptions, a 60.2 completion percentage, and a 101.9 quarterback rating. On December 13, Wentz underwent successful surgery on his ACL. Wentz was selected to his first Pro Bowl on December 19, but could not participate due to the aftermath of his recent knee surgery. He was ranked third by his fellow players on the NFL Top 100 Players of 2018. Led by Nick Foles, the Eagles defeated the New England Patriots 41–33 in Super Bowl LII, the first Super Bowl win in franchise history.