In 2014, Wilkins was called up to the Wales women's national rugby union team, making her international debut against Italy in the first match of the 2014 Women's Six Nations Championship, scoring two penalties. A gain of weight and decrease in fitness as a result of low confidence and motivation affected her performance throughout 2015 but an increase in training reversed all that the following year due to help she received from the WRU's conditioning and strength coach. Wilkins has played for the Wales national team 50 times since her debut in 2014, having reached the 50 cap milestone against Ireland at the 2021 Women's Six Nations Championship. She played 33 Women's Six Nations matches, scoring two tries and 77 points. Wilkins competed for Wales at the 2014 Women's Rugby World Cup and the 2017 Women's Rugby World Cup. She has also played for the Wales women's national rugby sevens team.