Jusufi was born into an ethnic Gorani family in the village of Zli Potok near Dragaš (Vardar Banovina, Kingdom of Yugoslavia). During his career, he played for FK Partizan, Eintracht Frankfurt, Germania Wiesbaden and FC Dornbirn, retiring in 1972. He was part of the Partizan squad when they became vice-champions of Europe after losing the 1966 European Cup Final against Real Madrid.