In 2014, Degenkolb most notably won the Belgian classic Gent–Wevelgem ahead of Arnaud Démare and Peter Sagan. During the Paris–Nice stage race, he won stage 3 from a bunch sprint, temporarily taking over the race lead, and went on to win the overall points classification. He also earned the points classification and 3 stages of the Tour Méditerranéen and 4 stages of the Vuelta a España. The first stage he won contained two categorised climbs and was raced in oven-like heat. The second one was a massive sprint where FDJ rider Nacer Bouhanni complained he had been unfairly pushed to the barriers by Degenkolb, who still retained the victory. The third success was a 'crazy finish' according to Degenkolb, who had the better of second placed Tom Boonen. The fourth victory came on Stage 17 and saw him edge Michael Matthews for the line. Right after the Vuelta and conquering the points classification jersey, Degenkolb had to be hospitalized for a lymphatic infection.