In his twenty-seventh league appearance of the 2015–16 season, on 20 April 2016, Matteo scored his first Manchester United and Premier League goal, a powerful volley from the edge of the penalty area, in a 2–0 victory against Crystal Palace. He was presented with the club's Man of the Match award for his performance in this fixture and hailed his 55th-minute strike as the best goal of his career, thus far. His cross, in the fourth minute of play, had also previously forced an own goal from Damien Delaney. Darmian featured in the 2016 FA Cup Final against Crystal Palace on 21 May, coming on in the 66th minute for Marcos Rojo, helping United achieve a 2–1 victory.