The Great Famine of 1315 began a number of acute crises in the English agrarian economy. The famine centered on a sequence of harvest failures in 1315, 1316 and 1321, combined with an outbreak of the murrain sickness amongst sheep and oxen between 1319 and 1321 and the fatal ergotism fungi amongst the remaining stocks of wheat. In the ensuing famine, many people died and the peasantry were said to have been forced to eat horses, dogs and cats as well to have conducted cannibalism against children, although these last reports are usually considered to be exaggerations. The Great Famine firmly reversed the population growth of the 12th and 13th centuries and left a domestic economy that was "profoundly shaken, but not destroyed".