London Irish moved into the Madejski in 2000 after a year of ground sharing at the Stoop Memorial Ground in Twickenham. On 11 January 2008, it was announced that London Irish had reached an agreement to continue playing home games at the Madejski Stadium until 2026. However, they were to leave after the 2019–20 season. Irish played their last game at Madejski on 1 March, 2020 when they were defeated by Wasps. The COVID-19 pandemic had truncated the season causing a premature end to their tenancy.