In March 2016, in Liverpool's first European matches against rivals Manchester United, Clyne won a penalty that Daniel Sturridge converted in the first leg, and conceded a penalty scored by Anthony Martial in the second, as Liverpool won 3–1 on aggregate in the last 16 of the UEFA Europa League. On 18 May, he played the full 90 minutes in the final, a 3–1 loss to Sevilla in Basel.