The Potez 452 was active as a reconnaissance aircraft during the early months of World War II. During that time there was no significant naval action in the Mediterranean where most of the French Navy was operating. After the French capitulation to Germany in June 1940, these aircraft continued to serve with their ships and as part of Vichy France's military, briefly engaged their former ally Great Britain. Other Potez 452s were deployed to French colonies in French Indochina, which included reconnaissance duty in the 1940–1941 Franco-Thai War between the Vichy French controlled colonies and Thailand and some remained in service until 1944, by which time the final survivors were retired. In 1937 a single Potez 452 had been supplied to the Imperial Japanese Navy Air Service for evaluation as the Potez HXP1.