Daly was named in the England team to face France at Twickenham in the first game of the 2017 Six Nations on Saturday 4 February. He scored a long-range penalty and was denied a try by a last-gasp tackle from the French. Daly started on the wing again against Wales in Cardiff on Saturday 11 February. With England losing 16-14 and 5 minutes left on the clock, Daly took a pass from Owen Farrell, escaped the clutches of Alex Cuthbert and sprinted 20 metres to dive over in the corner, winning the match for England. Daly scored his second try of the tournament during England's 36-15 win over Italy. In the 2019 Six Nations, Daly played at fullback and scored the second try in England's opening 32-20 away win over Ireland, grounding his own grubber kick following Jacob Stockdale's handling error under pressure.