In the 11th century, a bishop Michael is known through his seal; from the decoration it appears that he may have previously been a member of the clergy of the Hagia Sophia in Constantinople. In 1305 or 1306, an unnamed bishop of Chariopolis attended a synod called by Patriarch Athanasius I of Constantinople to condemn John Drimys. In 1347, the subordination of the bishopric of Chariopolis, which apparently had been vacant since the start of the Byzantine civil war of 1341–1347, to Heraclea was formally renewed by imperial "prostagma". In 1351, the local bishop, whose name is not recorded, participated in a synod against Barlaam of Calabria under Patriarch Callistus I of Constantinople.