Regarded by pundits as the best goalkeeper in Tunisia and one of the best in Africa of all-time, he is famous for controlling the ball with his feet and dribbling inside the penalty area. Mathlouthi won the 2011 African Nations Championship held in Sudan. The Confederation of African Football (CAF) chose Mathlouthi as the best goalkeeper in the 2015 Africa Cup of Nations held in Equatorial Guinea so he was in the CAF Team of the Tournament. He is known for his impressive performance during the 2007 CAF Champions League by holding many clean sheets during this competition despite being 23 years old.