Scofield married Elizabeth Clark Wright in 1867. Together they had five children: William, Donald, Sherman, Harriet, and Douglas. Scofield's four sons all worked at his architectural firm. The Scofields were members of First Baptist Church of Greater Cleveland. Elizabeth Scofield died in 1914 and was interred at Lake View Cemetery in a mausoleum designed by her husband. Three years later, in 1917, Scofield passed away at his home. He too was interred in the family mausoleum. The Scofield mausoleum was used as a temporary resting place for assassinated president James A. Garfield in 1881 while the construction of his memorial was undertaken nearby.