Harrison opened her 2016 indoor season winning the 60 metres hurdles in Lexington, Kentucky, Karlsruhe, Germany and Glasgow in 7.92. In a tightly competed race at the 2016 USA Indoor Track and Field Championships, Harrison took second place by one hundredth of a second to Brianna Rollins, setting a personal record of 7.77 seconds and moving herself into 13th place on the all-time lists. At the 2016 IAAF World Indoor Championships one week later, Harrison led the qualifying with 7.81 seconds. However, in the final she hit the first hurdle heavily and never recovered, ending in eighth while Nia Ali (the least favoured American) took the title.