The combination of Mediterranean climate, geography and geology of the region are conducive to growing quality wine grapes. John Patchett established the Napa Valley's first commercial vineyard in 1858. In 1861 Charles Krug established another of Napa Valley's first commercial wineries in St. Helena. Viticulture in Napa suffered several setbacks in the late 19th and early 20th centuries, including an outbreak of the vine disease phylloxera, the institution of Prohibition, and the Great Depression. The wine industry in Napa Valley recovered, and helped by the results of the Paris Wine Tasting of 1976, came to be seen as capable of producing the best quality wine – equal to that of Old World wine regions. Napa Valley is now a major enotourism destination.