Bowe continued to represent Ireland throughout 2010. He was selected in Ireland's squad for the 2011 Six Nations Championship, and scored the opening try of Ireland's demolition of a Grand-Slam chasing England on 19 March. He went to the 2011 Rugby World Cup, his first such tournament, and scored a try against the USA in Ireland's opening Pool C game. He was selected in the squad for the 2012 Six Nations Championship, during which he rediscovered his try-scoring ability. scoring 5 tries in Ireland's first three games, including braces against Italy and France.