By the late 16th century Norwich had grown to become the second-largest city in England, but over one-third of its population died in the plague epidemic of 1579, and in 1665 the Great Plague again killed around one-third of the population. During the English Civil War Norfolk was largely Parliamentarian. The economy and agriculture of the region declined somewhat. During the Industrial Revolution Norfolk developed little industry, except in Norwich which was a late addition to the railway network.