Gesualdo died in isolation, at his castle Gesualdo in Avellino, three weeks after the death of his son Emanuele, his first son by his marriage to Maria. One 20th-century biographer has raised the possibility that he was murdered by his wife. He was buried in the chapel of Saint Ignatius, in the Church of the Gesù Nuovo, in Naples. The sepulchre was destroyed in the earthquake of 1688. When the church was rebuilt, the tomb was covered over, and now lies beneath it. The burial plaque, however, remains visible.