The mid-3rd century saw the empire plunged into a military and economic crisis which almost resulted in its disintegration. It consisted of a series of military catastrophes in 251–271 when Gaul, the Alpine regions and Italy, the Balkans and the East were overrun by Alamanni, Sarmatians, Goths and Persians. At the same time, the Roman army was struggling with the effects of a devastating pandemic, now thought to have been smallpox, the Plague of Cyprian which began in 251 and was still raging in 270, when it claimed the life of Emperor Claudius II Gothicus (268–70). The evidence for the earlier Antonine pandemic of the late 2nd century, probably also smallpox, indicates a mortality of 15–30% in the empire as a whole. Zosimus describes the Cyprianic outbreak as even worse. The armies and, by extension, the frontier provinces where they were based (and mainly recruited), would likely have suffered deaths at the top end of the range, due to their close concentration of individuals and frequent movements across the empire.