Among the cities in the region, Varaždin and Zagreb occupy particularly prominent places in terms of culture. Varaždin is often considered the most significant centre of baroque culture and heritage in Croatia. That claim is reflected in the city's historical architecture and cultural events, based on traditions of the city from the era. Zagreb, on the other hand, is the largest cultural centre, not only in the region, but also in Croatia as a whole. It is home to dozens of galleries, museums, and theatres as well as being the site of numerous landmarks. The landmarks include the Zagreb Cathedral, founded in 1093 and rebuilt numerous times since, the last major reconstruction being after the 1880 earthquake. The cathedral is the tallest structure in Croatia. Zagreb is the most significant centre of scientific work and education in the region and the entire country. It is the site of the University of Zagreb—the oldest place of higher education in Croatia and Southeast Europe, operating continuously since 1669. It is also home to the Ruđer Bošković Institute—the leading Croatia's scientific research institute—and to the Croatian Academy of Sciences and Arts.