On 10 February, "Biloxi" joined TG 58.4 and sailed for operations against Iwo Jima. Following carrier-launched fighter sweeps against Japanese airfields in the Tokyo area, the task group closed Iwo Jima to support landing operations. During the morning of 19 February, "Biloxi" provided naval gunfire support for the troops ashore. She then shifted to harassing fire that evening. This pattern of operations continued until the 21st when 5 inch mount #6 fired into the barrels of gun mount #5, slightly injuring several sailors and destroying the latter mount.