Elayi taught literature in Emilie de Rodat school in Toulouse between 1966 and 1968 before moving on to Notre-Dame school in Lyon where she taught for the next four years. In 1973, Elayi obtained a teaching position in the Lebanese University's faculty of letters in Beirut. Elayi's interest for the history of the Phoenicians was stirred during her short stay in Beirut. When the Lebanese civil war broke out in 1975, Elayi moved to Baghdad where she taught French literature at the Al-Mustansiriya University until 1978. Elayi settled in Paris in 1980, she taught in the Lycée Charlemagne before joining the CNRS as a researcher in ancient history in 1982.