Andújar got off to a 12–1 start in , and made his fourth All-Star team. The Cardinals and New York Mets became embroiled in a heated battle for the NL East crown that came down to the wire. Andújar went 3–1 with a 4.29 ERA against the Mets that season. A 5–2 loss on October 2 against Dwight Gooden allowed the Mets to pull within a game of the Cardinals. This loss became perhaps the most memorable game Andújar pitched in the rivalry that developed between the two clubs. The Cardinals won the following day and ended up taking the division by three games over the Mets. Andújar ended the season at 21–12 with a 3.40 ERA. In the 1985 National League Championship Series, He was ineffective in his Game 2 start against the Los Angeles Dodgers, which put the Cardinalss in a two-game hole. St. Louis came back to win the following four games, which paved the Cardinals' way to the World Series. (Andújar started the decisive Game 6 of the NLCS but did not figure into the decision.)