Bregalnica (, ) is the second largest river in North Macedonia. It starts as a spring near the mountain city of Berovo and it passes near the cities of Makedonska Kamenica, Kočani, Vinica and Štip, before joining the river Vardar on its way to the Aegean Sea. Recent issues have concentrated around the pollution of the river, as many of the factories located in the cities through which it passes used it as a dumping ground for waste waters, which is further aggravated with the pesticide-treated waters of the extensive rice fields near the city of Kočani. It was the place of Battle of Bregalnica.