In 1985, the Gay and Lesbian Alliance Against Defamation (GLAAD) was created and Wolfe joined in an interest with the AIDS crisis. This same year, Wolfe was arrested for sitting in on the hearing for the Gay Rights Bill with a “Lesbian Liberation, We Won’t Go Away” sign, refusing to leave after the hearing was over and they didn't vote. As well in 1985, Wolfe got involved with ACT UP and attended the 24-hour picket of Sloan Kettering as well as the March on Washington in October 1987. Because of Wolfe's previous political experience, she led the way in getting ACT UP involved in policy instead of just advocacy to continue this mass movement. She also coordinated Woman and AIDS, an event at Shea Stadium where the METS played. Around 60 men and woman from ACT UP went to the game with signs to be televised across America and reach the large crowd of fans at the game. She was also involved with Stop the Church and organized the campaign to change the CDC definition of AIDS. In addition, Wolfe worked on campaigns and committees for AIDS research, pharmaceuticals, and more access to care and education.