During the summer of 1759 "Squirrel" was part of the British naval force at the siege of Quebec. On 18 July she, under Hamilton's command, was part of a small squadron that ran up the river past the city. The vessels included , of 50 guns, three transports with three companies of grenadiers and a battalion of the Royal Americans, and two armed sloops. , of 32 guns, was part of the squadron, but she grounded and did not make the passage. "Squirrel" was among the Royal Navy vessels that received prize money for the capture of a number of small vessels in the St Lawrence River in 1759.