In 1966, after taking part in a singing contest with a cover version of The Monkees' "I'm a Believer", she was put under contract by CBS. In 1967 Musiani got her first success with "Ode per Billie Joe", a cover version of Bobbie Gentry's "Ode to Billie Joe". In the following years she took part to the most important musical events in Italy, including Canzonissima, Cantagiro, Festivalbar and two editions of the Sanremo Music Festival, in 1974 and in 1975.