Battery F commenced its participation in the Vicksburg campaign when it moved to Bruinsburg, Mississippi, on 25–30 April 1863. The battery engaged in the Siege of Vicksburg from 18 May to 4 July, including the 19 and 22 May assaults. For the campaign, Battery F under Captain J. W. Powell was in McArthur's 6th Division, Major General James B. McPherson's XVII Corps. After the capture of Vicksburg, the battery took part in the Jackson Expedition. On 5–10 July, the unit marched to Jackson, Mississippi, and on 10–17 July, it engaged in the siege of Jackson, Mississippi. From August 1863 to November 1864, Battery F formed part of Artillery, 4th Division, XVII Corps. On 15 August, Battery F moved to Natchez, Mississippi where it remained on duty until February 1864. From Natchez, it joined an expedition to Harrisonburg, Louisiana, on 1–7 September 1863, including the capture of Fort Beauregard on 4 September. From 2 February–3 March 1864, Battery F participated in the Meridian Campaign, after which it garrisoned Vicksburg until April.