The 6th Missouri Infantry was an infantry regiment of the Confederate States Army during the American Civil War. The regiment was formed on August 26, 1862, when two existing units were combined. Later that year, the regiment was then lightly engaged at the Battle of Iuka and saw heavy action at the Second Battle of Corinth. In 1863, the regiment was engaged at the Battle of Port Gibson, and was part of a major charge at the Battle of Champion Hill. After a defeat at the Battle of Big Black River Bridge, the regiment took part in the siege of Vicksburg, where it saw heavy fighting. The siege of Vicksburg ended on July 4th with a Confederate surrender; after being exchanged, the regiment combined with the 2nd Missouri Infantry to form the 2nd and 6th Missouri Infantry (Consolidated). The 6th Missouri Infantry ceased to exist as a separate unit.