Zalatoris' first professional victory came in July 2020, when he won the TPC Colorado Championship by one stroke. The win moved him to first place on the Korn Ferry Tour points list and qualified him for the U.S. Open at Winged Foot. At the U.S. Open, he aced the par-3 7th hole during the first round, very nearly replicating it six holes later, and tied for sixth place, at five-over par, alongside world number one Dustin Johnson; it was his first top-10 finish in a major championship. He followed it up with a T8 at the Corales Puntacana Resort and Club Championship, and secured Special Temporary Member status after the Bermuda Championship in early November.