By the time the Great Patriotic War began, the band was in the Belarusian SSR where it was staging a series of concerts in the Minsk Military District. Where the band performed at the Narev river, one side saw the band's performance while the other saw the German Wehrmacht preparing for Operation Barbarossa. The following day the war broke out. On 25 June 1941, the band returned to Moscow, three days after the start of hostiities. In September of 1941, twenty-eight musicians from the band received an order to go to the Western Front. A month later, the band got surrounded by the German 3rd Panzer Army and 4th Panzer Army near the city of Vyazma during the Battle of Bryansk. Although receiving the orders to break through the enemy circle and withdraw, the transport vehicle that was meant to do so was caught in the crossfire of multiple units. Nine musicians died immediately, ten going missing. Despite this setback, the band never ceased to perform over the course of the war, staging over 500 concerts and making 150 appearances on the All-Union radio. Among its activities were the ceremonies of awarding units their colors and state honors.