Wegner has umpired in ten Division Series (2003, 2004, 2005, 2008, 2009, 2012, 2013, 2017, 2019, 2020), five League Championship Series (2007, 2014, 2015, 2016, 2018), and two World Baseball Classics (2009, 2013). He also officiated in the 2008 All-Star Game, the 2014 and 2018 National League Wild Card Games, and the 2013 World Series and recently the 2017 World Series. Wegner wears uniform number 14, and previously wore uniform number 47. For the 2018 regular season he was found to be a Top 10 performing home plate umpire in terms of accuracy in calling balls and strikes. His error rate was 7.28 percent. This was based on a study conducted at Boston University where 372,442 pitches were culled and analyzed.