Spyridon Mercouris () (1856-1939) was a Greek politician and long-serving Mayor of Athens in the early 20th century. He was born in Ermioni, Argolida, in 1856 to a prominent and wealthy family that had taken part in the Greek War of Independence in the 1820s.He was the son of Georgios Mercouris, captain and son of Spyridon Mercouris, and Theodora / Theodota, daughter of the chieftain of the Greek revolution and later MP of Ermionida and authorized representative in national assemblies Stamatis Mitsas, and sister of the military and also MP of Ermionida Antonios Mitsas. Through the Mitsa family, he was a close by marriage relative with the historical Zakynthian family of the Motsenigos.