Matuidi began his football career playing for amateur clubs in the Île-de-France region, such as US Fontenay-sous-Bois and CO Vincennois. In 1999, he was selected to attend the prestigious Clairefontaine academy. After departing Clairefontaine, Matuidi joined semi-professional club Créteil and spent three years developing in the club's youth academy. In 2004, he signed with professional club Troyes and made his professional debut in the 2004–05 season. After three seasons with Troyes, Matuidi joined Saint-Étienne. With Saint-Étienne, he played European football for the first time after participating in the 2008–09 edition of the UEFA Cup. In the 2009–10 season, he was named first-choice captain under manager Alain Perrin. In July 2011, after four seasons with Saint-Étienne, Matuidi transferred to Paris Saint-Germain on a three-year deal. He won 16 domestic honours during his time with the club, including four consecutive Ligue 1 titles. In 2017, he joined Italian side Juventus, winning a domestic double in his first season, followed by two more consecutive league titles over the next two seasons, as well as the 2018 Supercoppa Italiana. He joined MLS club Inter Miami in the summer of 2020.