Andrei of Polotsk (, , , ca. 1325 – 12 August 1399, in the Battle of the Vorskla River) was the eldest son of Algirdas, Grand Duke of Lithuania, and his first wife Maria of Vitebsk. He was the Prince of Pskov (through his deputy Yuri, 1342–1348) and Polotsk (1342–1387). As the eldest son of the Grand Duke, Andrei claimed his right to the throne after his father's death in 1377. Algirdas left Jogaila, his eldest son with his second wife Uliana of Tver, as the rightful heir. Andrei's rivalry with Jogaila, Grand Duke of Lithuania and later King of Poland, eventually led to his demise.