This regiment would initially first serve in the Dutch Wars, and the Siege of Luxembourg, playing minor roles. They would enter combat at numerous points in the War of the League of Augsburg, the Battle of Neerwinden, the early bombardment of Brussels, and the War of the Spanish Succession, proving effective in most of these encounters. Following more Succession crisis in Europe, with the Penthievre Regiment serving in most of these wars, (War of the Spanish Succession, War of the Polish Succession, War of the Austrian Succession) the Penthievre Regiment lost its commander in the Seven Years War, and took no further action in following events.