The station facilities are accessible for the disabled. In 2019, the station had an average daily ridership of 3,492 passengers, making it the 192nd busiest station in the network and the least busy of the line. Since it was opened, Tlaltenco station has had multiple incidents, including a 20-month closure in 2014 due to structural faults found in the elevated section of the line, a closure caused by the 19 September 2017 earthquake, and the subsequent collapse of the track near Olivos station in 2021.