Domnentiolus is first mentioned in April, 531, at about the time of the Battle of Callinicum. The Iberian War was still ongoing. His uncle Bouzes was stationed at Amida, an illness preventing him from campaigning. He tasked Domnentiolus with leading an army to Abhgarsat. This location is only mentioned once by Zacharias. The Byzantine forces faced the Sassanid army and were defeated. Domnentiolus himself was captured by his enemies and transported to the interior of the Sassanid Empire. In 532, the Eternal Peace was concluded between the two powers. Domnentiolus was released "in an exchange of prisoners".