On 18 February 2016 Haryanto was confirmed as a driver of Manor Racing for the 2016 Formula One season alongside 2015 DTM Champion Pascal Wehrlein. He made his debut at the 2016 Australian Grand Prix, however got off to a rocky start with an incident involving Romain Grosjean when they collided in the pit lane during practice. Haryanto was later issued a three-place grid penalty for the incident, as well as two penalty points added to his licence. Haryanto retired from his debut race due to a drive link problem on the 18th lap. Amusingly however, Haryanto was the most-voted driver in F1's newly-introduced Driver of the Day vote, before the award went to Romain Grosjean, who scored points for the debuting Haas team.