Despite being ranked no. 19 in the world entering Wimbledon, Isner was seeded 24th by the tournament committee due to his lack of experience on grass, but was moved up to 23rd following the withdrawal of Radek Štěpánek. In the first round, Isner played Nicolas Mahut in the longest match in tennis history, prevailing 6–4, 3–6, 6–7, 7–6, 70–68. However, fatigued and having little time to recover his energy, Isner was beaten by Thiemo de Bakker in the second round, 0–6, 3–6, 2–6, having served no aces. He also pulled out of the doubles, where he and Querrey had been 12th seeds. Despite having been eliminated in the second round, Isner's total of 113 aces were more than any other player throughout the championship. His Wimbledon performance brought his ranking to a career-high no. 18 in the world.