It is during the rule of the Ottoman Empire that the form Kafr ʿInān (Kafr 'Anan) first appears. The village is listed in the tax records of either 1549 or 1596, as forming part of the "nahiya" (subdistrict) of "Jira", part of Safad Sanjak, with 21 households and 8 bachelors; an estimated population of 259. All the villagers were Muslim. They paid taxes on goats, beehives and on its press, which was used either for olives or grapes; a total of 12,272 akçe. All of the revenue went to a Waqf. A map from Napoleon's invasion of 1799 by Pierre Jacotin showed the place, named as "K. Hanein".