Yastrzemski and the Red Sox suffered another World Series loss in , losing four games to three to the Cincinnati Reds. He made the final out in Game 7 on a fly out to center, trailing by one run. Coincidentally, he also made the final out of the 1978 American League East tie-breaker game with a foul pop to third base. This game featured Bucky Dent's famous homer (although Reggie Jackson's was the eventual winning run). Earlier in the game, Yastrzemski began the scoring with a home run off left-handed pitcher Ron Guidry, who was having a career year (25 wins, 3 losses and a 1.74 ERA). It was the only homer the Cy Young Award winner allowed to a left-hander all season.