Comnen was assigned to lead Foreign Affairs during the early stages of King Carol II's authoritarian regime. His ministerial term was highly turbulent, overlapping with the expansion of Nazi power, Western appeasement, and a sudden deterioration of Romanian–Soviet relations. Comnen recognized the "Anschluss", helped "liquidate" the Abyssinian question, and tried to obtain guarantees from Romania's hostile neighbors at Bled and Salonika. A full crisis followed the Munich Agreement, during which Comnen worked to preserve both a Czechoslovakian state and the Little Entente. He tacitly gave the Soviet Air Forces access to Romania's airspace, and refused to participate in a partition of Carpathian Ruthenia.