Musso was fatally injured during the 1958 French Grand Prix at Reims when his Ferrari hurtled off the course on the 10th lap of the 50 lap race. Running wide at the tricky "Gueux Curve" while chasing the leader, fellow Ferrari driver Mike Hawthorn, Musso's Ferrari struck a ditch and somersaulted. Musso was airlifted to hospital with critical head injuries and died later that day. Hawthorn went on to win the race.