Zampedri was seriously injured in the 1996 Indianapolis 500, suffering severe foot and leg injuries on the last lap of the race. While running fourth, Zampedri was collected in a crash with Roberto Guerrero and Eliseo Salazar. Zampedri's car became airborne and crashed into the fence at the head of the main straightaway. The car came to rest near the pit entry. A portion of Zampedri's left foot and three toes had to be amputated as a result of the accident.