Estudiantes earned its place in the final after having won the 1910 Copa de Competencia Jockey Club, where the squad beat Argentino de Rosario (1–0 in Palermo), Newell's Old Boys (3–3, 4–3 in Palermo and Rosario respectively), and Gimnasia y Esgrima in the final (3–1 at Ferro C. Oeste). The match was held in Gimnasia y Esgrima Stadium in Palermo (that had been completely refurbished for the Copa Centenario Revolución de Mayo) on 7 August 1910.