After a relatively disappointing first season with the club, in which Džeko scored only 8 Serie A and 10 goals in all competitions for Roma, he started the 2016–17 season with 12 goals in 15 games, 17 goals in 20 overall, thus equaling the start of the season that Gabriel Batistuta had, in which he won the league title with Roma. On 24 November 2016, he scored a hat-trick in the Europa League, in a 4–1 win over Viktoria Plzeň. On 16 February 2017, he also scored a hat-trick in the first leg of a Europa League match against Villarreal, which Roma won 4–0. On 12 March 2017, he became the fourth Roma player to reach 30 goals in all competitions in a season.