On 12 August 2014, Martino was introduced as the new manager for the Argentine national team, succeeding Alejandro Sabella who took the side into the final against Germany at the World Cup in Brazil. In the 2015 Copa América, he reached the final, in which Argentina were runners-up after losing to hosts Chile on penalties. They also finished as runners-up in the Copa América Centenario Final on 26 June 2016 against Chile, again losing on penalties. On 5 July 2016, Martino resigned.