In 1805, Lusignan took command of a division in the Tyrol. In 1806 he became Proprietor (Inhaber) of "Lusignan" Infantry Regiment # 16, a position which he held until his death. The War of the Fifth Coalition found him in command of a division in the III Armeekorps under the command of Prince Friedrich of Hohenzollern-Hechingen. While leading his troops at the Battle of Teugen-Hausen on 19 April 1809, he was wounded in the head. Though forced into retirement by his injury, a grateful emperor elevated him to the rank of Feldzeugmeister on 29 May. He died on 23 December 1832 at Ivanovice na Hané in the modern-day Czech Republic.