She succeeded in defending her gold medal again at the 2010 Commonwealth Games at Delhi. The Northeast Frontier Railway employee set a new Games snatch record with a lift of 90 kg in her final attempt. Renu added 107 kg to her snatch record to total 197 to win the gold medal for the second successive time. She heaved 88 kg and broke the prior record held by Maryse Turcotte from Canada during the 2002 Games, and improved it in her next attempt to bring it up to 90 kg. Her national record is 93 for snatch, 119 for clean jerk and 209 for total. She dedicated her gold medal to the people of India and to the Indian Weightlifting Federation, saying that her win would help the Federation to recover from their recent setbacks. She expressed her pride and the significance of her achievements for someone hailing from a financially troubled background, and described her medal as a token of acknowledgement for the efforts her family, and coaches put in for her training.