Mario Bertini (; born 7 January 1944) is an Italian former professional footballer who played as a defender and midfielder. Throughout his career Bertini played for Italian clubs Empoli, Fiorentina, Inter Milan, Prato, and Rimini; he spent nine seasons with Inter, winning a Serie A title in 1971. At international level, he represented the Italy national team on 25 occasions between 1966 and 1972, scoring twice, and was a member of the team that reached the 1970 FIFA World Cup Final.