On 4–5 June 1942, "Uranami" participated in the Battle of Midway by escorting Admiral Isoroku Yamamoto's Main Body, suffering minor damage after the battle in a collision with sister ship , requiring a return to Kure Naval Arsenal for repairs. Once these repairs were complete, "Uranami" escorted the armed merchant cruiser "Kiyozumi maru" as far as Singapore and then continued on to Mergui for a projected second Indian Ocean raid. The operation was cancelled due to the Guadalcanal campaign, and "Uranami" was ordered to the Solomon Islands instead. During the Battle of the Eastern Solomons on 24 August "Uranami" escorted the fleet supply group to Guadalcanal. Throughout September and October, "Uranami" participated in a very large number of "Tokyo Express" high speed transport missions to Guadalcanal.