Epidemic disease was the overwhelming cause of the population decline of the Indigenous peoples. After initial contact with Europeans and Africans, Old World diseases caused the deaths of 90 to 95% of the native population of the New World in the following 150 years. Smallpox killed from one third to half of the native population of Hispaniola in 1518. By killing the Incan ruler Huayna Capac, smallpox caused the Inca Civil War of 1529–1532. Smallpox was only the first epidemic. Typhus (probably) in 1546, influenza and smallpox together in 1558, smallpox again in 1589, diphtheria in 1614, measles in 1618—all ravaged the remains of Inca culture.