Lowe arrived back at Gibraltar shortly after the outbreak of war between Britain and France in early 1793. The 50th were sent to take part in the Defence of Toulon which had been seized by an Allied force under Lord Hood after an invitation by French Royalists in the city. The 50th arrived too late to assist the defence, as the Allied forces had already withdrawn from the city. They were then redirected to Corsica, a French-owned island, where British troops had been sent to join with Corsicans under Pasquale Paoli. Lowe's regiment served as part of General Dundas's force during the Siege of Bastia and Siege of Calvi driving the French from the island. The regiment was stationed in Bastia. Lowe volunteered to fetch supplies from Livorno in Italy, but nearly died of malaria during the journey there.