Scifo made his first team debut with R.S.C. Anderlecht in 1983, at the age of 17. After winning three Belgian First Division championships with the club, and helping the team to the 1984 UEFA Cup Final, only to lose out to Tottenham on penalties, Scifo earned a reputation as one of the most promising young stars of his generation, and moved to Italian club Internazionale in 1987 for a fee of 7.5 billion Lire. After an unsuccessful spell in Milan, which saw him manage only four league goals in 28 appearances, he moved to French club Bordeaux in 1988 where he again disappointed, and faced injuries and conflict with senior squad members. His career was revived by a successful move to Auxerre in 1989, at the age of 23, under manager Guy Roux, which led to a return to Italy with Torino in 1991; his second spell in Serie A was more successful, as he reached the 1992 UEFA Cup Final in his first season with Torino, and won the Coppa Italia the following season. Scifo then moved to AS Monaco in 1993, where he endured a similar level of success and won the French championship in 1997. He returned to Anderlecht later that year and won his fourth Belgian league title in the 1999–2000 season. He joined Charleroi in 2000, but retired later in the same season, at the age of 36, after being diagnosed with chronic arthritis. In total, Scifo scored 121 league goals in 478 official matches.