His son Henry Holland, 3rd Duke of Exeter would succeed, and though he married the daughter of Richard, Duke of York, he remained a staunch Lancastrian in the War of the Roses. He was a commander in the Lancastrian victories at Wakefield (1460) and St Albans (1461), before being defeated at Towton and attainted while in exile, and his properties awarded to his wife, the sister of Edward IV, who had separated from Holland. With the Readeption of Henry VI in 1470, Holland was restored to his lands but was again defeated at Barnet, deprived and divorced. He drowned under mysterious circumstances in 1475, his only child having predeceased him.