Salvio made his official debut for Atlético in the 2009–10 UEFA Europa League against Galatasaray on 18 February 2010, and scored his first goals for the "Colchoneros" in a 3–1 La Liga home win over Tenerife on 25 April. On 12 May he appeared as a substitute in the Europa League final against Fulham, coming on as a substitute for José Antonio Reyes in the 76th minute of the 2–1 triumph.