Under his father, at the beginning of the War of the Spanish Succession the administration of the Imperial Reichspost was moved from Brussels to Frankfurt am Main. When his father died, Anselm Franz was appointed Postmaster General by Charles VI in 1715, and returned to the family's home in Brussels, but the city now had no significance for the Reichspost. He therefore moved back to Frankfurt am Main in 1724, where he bought a plot of land on which he later started construction of the Baroque Palais Thurn und Taxis in 1729. In 1725, he was able to lease the postal system of the Austrian Netherlands as a Habsburg fief. His move to Frankfurt was drawn out over several years, as the city council had some objections and in any case the construction of his palace took its time. From 1737 he lived in the still unfinished palace in Frankfurt, but then returned in 1739 to Brussels, where he died unexpectedly.