Clayton's first appearance at the UK Open came in the 2016 edition, but he was defeated 6–3 by James Wilson in the second round. Clayton recorded a quarter-final showing at the eighth Players Championship and reached his first semi-final at the 12th event, but was whitewashed 6–0 by Gary Anderson. A 2–0 victory over Tony Darlow saw Clayton claim the non-ranking Worthingtons Darts Champion of Champions title. He lost 6–3 to Darren Webster in round one of the Players Championship Finals.