The Crisis of the 17th century took a heavy toll in many Castilian cities, and particularly in Guadalajara. The city was affected by the 1610 expulsion of the moriscos both in terms of the net demographic loss (10% of the population) as well as by their critical weight in key sectors of the local economy such as the artisanate and trade. Many palaces were left forsaken. The Mendozas left the city for good in 1657.