On 12 August 2018, Salcedo played in his first competitive game of the season in Frankfurt's 5–0 loss to Bayern Munich for the DFL-Supercup. On 1 September, during a league match against Werder Bremen, which Frankfurt lost 2–1, Salcedo suffered a high ankle sprain, meaning he would be ruled out of action for an undetermined amount of time. On 2 December, he reappeared as an unused substitute in Frankfurt's 2–1 loss to Wolfsburg. Six days later, he made his return to the starting eleven in Frankfurt's 1–0 loss to Hertha Berlin.