After his death the city fell under Seleucid dominion, and during the wars between Seleucus Callinicus and Ptolemy Euergetes it passed from the hands of the Seleucids into those of the Ptolemies. Whether these latter set the town free, or whether it emancipated itself, is uncertain; at any rate it entered into the relation of sympolity with the Aetolian League. In 287 BC, the city was severely damaged by an earthquake, as reported by the Roman historian Justin (17.1.1-3). In 277 BC, near Lysimachia the Macedonian king Antigonus II Gonatas defeated the Gauls. As the Aetolians were not able to afford the town the necessary protection, it was destroyed again in 197 BC by the Thracians during the war of the Romans against Philip V of Macedon. The Seleucid king Antiochus the Great restored the place, collected the scattered and enslaved inhabitants, and attracted colonists from all parts by generous promises. This restoration, however, appears to have been unsuccessful, and under the dominion of Rome it decayed more and more.