In May 2019, Sandro was included in Brazil's 23-man squad for the 2019 Copa América on home soil by manager Tite. In Brazil's final group match on 22 June, a 5–0 win against Peru, Sandro made a substitute appearance, coming on for Filipe Luís. In the quarter-final match against Paraguay on 27 June, he once again made a substitute appearance, replacing the injured Filipe Luís at half-time; following a 0–0 draw, Brazil advanced to the semi-finals 4–3 on penalties. Sandro started in the 2019 Copa América Final against Peru on 7 July, at the Maracanã Stadium; the match ended in a 3–1 victory to Brazil.