Al-Amoudi was a founder of the Islamic Society of Boston (ISB). He signed the Society's articles of incorporation and served as the first president of the Society's Cambridge, Massachusetts mosque, which was also attended by the Boston Marathon bombers (Dzhokhar Tsarnaev and his brother, Tamerlan Tsarnaev), as well as by convicted terrorists Aafia Siddiqui and Tarek Mehanna.