In 2010, Felix focused on running more 400-meter races. Running the 200 meters and the 400 meters, she became the first person ever to win two IAAF Diamond League trophies in the same year. She continued her dominance by winning 21 out of 22 races, only losing to Veronica Campbell-Brown in New York. Felix also became the U.S. 100 meters champion by winning the sprint in 11.27 seconds against a strong −2.5 m/s headwind.