In 2006, Blanton's ERA rose over a full point to 4.82 and gave up the fifth highest number of hits in the American League (241), resulting in a .309 batting average against. However, he had four more wins than the previous year, posting a 16–12 record, striking out 107 batters and walking 58. He pitched his first career complete game shutout against the Kansas City Royals on May 31. Blanton did not pitch in the ALDS for the Athletics, but was named to the roster for the ALCS, where he pitched two innings in one appearance, allowing no hits or runs.