Marking his England debut with a hat-trick of tries in the 58–3 win over Romania in Bucharest in May 1989, Guscott received a call-up for the in-progress British and Irish Lions tour of Australia, making a series-winning contribution in the second and third Tests. He travelled to New Zealand in 1993 with the Lions, playing in all three Tests; though in this particular tour the Lions lost 2 matches to 1.