"Nizam" spent the early part of her service in the Atlantic, then was reassigned to the Mediterranean, where she was involved in the Crete and Syria-Lebanon Campaigns, the Tobruk Ferry Service, and the Malta Convoys. During 1942, the destroyer was involved in Operation Vigorous and the Madagascar Campaign. The next year saw the ship involved in patrols of the Indian and South Atlantic oceans, searching for German ships and submarines, and rescuing the survivors of U-boat attacks. After returning to Australia for a refit at the end of 1944, ten sailors were washed overboard in February 1945, with none ever seen again. The rest of World War II was spent operating in the Philippines and New Guinea regions.