There is no information available on his father, thus historians assume he died in his youth. Mantigirdaitis was married twice. His first wife was Anna, daughter of Jonas Vėževičius, regent of Smolensk. They had a son and a daughter. Their son Jonas died in the Battle of Vedrosha ending the family line. Their daughter Sophia married Stanisław Kiszka, who inherited the family's substantial wealth. Mantigirdaitis' second wife was Anna, daughter of Alexander Olshanski or of , son of Kaributas; they had no children. In 1482, Anna funded the Chapel of Holy Trinity in Vilnius Cathedral. It is likely that Mantigirdaitis funded the Catholic church in Iwye, his most important estate.