In response to the Berlin Crisis of August 1961, "Tweedy" was recommissioned on 2 October of that year. Following refresher training, she was assigned the home port of Newport, Rhode Island, and commenced antisubmarine barrier duties in the Caribbean early in 1962. Throughout the year, she engaged in fleet and type exercises, made goodwill visits, and served as flagship for Escort Squadron 12. On 12 June, as "Tweedy" steamed from Pensacola to Norfolk, Virginia, she came upon nine Cuban nationals in distress after two days at sea in an open, 14-foot boat. "Tweedy" aided the refugees and, later in the day, transferred them to U.S. Coast Guard representatives for assistance on their way to Miami.