In Toronto's last match of the regular season on 22 October 2017, a 2–2 away draw to Atlanta United FC, the former club broke the league's point record of 68 points, set by LA Galaxy in 1998, by one point. Eight days later, in the first leg of the Eastern Conference semi-finals in the play-offs, Vázquez scored the opening goal in a 2–1 away win over the New York Red Bulls. On 29 November, in the return leg of the Eastern final against Columbus Crew SC, at BMO Field, he missed a penalty in the 26th minute, but later set up the only goal of the match scored by Altidore, which saw his side emerge conference winners for the second consecutive year and earn a place in the MLS Cup Final. On 9 December, in the decisive match played at the same venue, he was involved in Altidore's opener and subsequently scored the final goal in a 2–0 win over the Seattle Sounders FC for an unprecedented domestic treble.