Maʿsarteh is identified as the town of Madaranzu in Bit-Zamani, which was conquered by Ashurnasirpal II, King of Assyria, in 879 BC. It is later mentioned by Theophylact Simocatta and George of Cyprus as Matzaron (, ). The town was likely captured by a Sasanian army in 573 at the time of the siege of Dara, during the Roman-Sasanian War of 572-591, but was retaken and the fort was restored by the Roman commanders Theodore and Andrew in 587.