On February 23, 2021, Gobert, alongside teammate Donovan Mitchell, was once again named a Western Conference reserve for the 2021 NBA All-Star Game, marking the pair's second consecutive All-Star selection. On March 22, Gobert logged 21 points, 10 rebounds and a career-high nine blocks in 120–95 victory over the Chicago Bulls. On June 9, 2021, Gobert was named the NBA Defensive Player of the Year for the third time in four years, making him the fourth player in NBA history to win three or more of the award. Gobert's win marked the first time in NBA history where four consecutive defensive player of the year awards had been won by international players. On June 11, Gobert recorded a playoff career-high 20 rebounds in a Game 2 second-round victory over the Los Angeles Clippers.