In Game 3 of the 2020 National League Championship Series, he was one of three Dodgers to hit a home run in the first inning, marking the first time that three players from the same team had homered in the first inning of a playoff game. On Pederson's playoff success, Dodgers starting pitcher Alex Wood quipped, "They call it 'Joctober' for a reason." Pederson had seven hits in 18 at bats in that series. In Game 5 of the 2020 World Series, Pederson hit the fifth home run of his World Series career, a second-inning solo shot against Tyler Glasnow that would prove the winning margin of victory in Los Angeles's 4–2 triumph. Max Muncy noted that "The guy performs on the huge stage. This is just what he does." In the World Series, Pederson had four hits in 10 at bats as the Dodgers won the championship.