Simone started off as a youth product of Deportivo Cali. He took part in the 2010 edition of the Copa Colombia where Cali eventually won. He then gained the interests of Inter Milan where he was an unused sub in the 2011 Supercoppa Italiana, where Inter lost to bitter rivals A.C. Milan. After one season, he was sold to Parma before being loaned out to low division club Martina Franca.