Powers attended Michigan State University for four seasons. Powers couldn't play for Michigan State in her first year due to a torn achilles tendon that she suffered in practice before the season started. In her second year, Powers came back healthy and averaged 13.8 points per game in her first season for Michigan State. During her first season, Powers had 26 points and 18 rebounds against Hampton University in the first round of the NCAA Tournament, which was the third-most points scored by a Michigan State Spartan in the NCAA Tournament, while her rebounding performance broke Michigan State's NCAA Tournament single-game record. By the end of her first season, Powers was named to the All-Big Ten First Team, becoming the first Michigan State freshman to ever be named to the First Team. She was also named to the Big Ten All-Freshman Team and was a co-recipient for both Michigan State's Player of the Year and Spartan Hustle award. In her second season with Michigan State, Powers had the best year of her college career, averaging 21.9 points and 12.1 rebounds per game. During the season, she had 24 double-doubles, which tied her for first on the All-Big Ten First Team and was the third-most in the NCAA. In her final season with Michigan State, Powers averaged 21.8 points and 9.2 rebounds per game. In February 2016, Power earned espnW player of the week honors following her career-high 40 points (on 14–26 field goal shooting) along with 8 rebounds and 6 assists in a 114–106 win against Minnesota. By the end of the season, she was named to the All-American Third Team and the All-Big Ten First Team for the third time. Following her senior season, Powers entered the 2016 WNBA draft.