In 2018, Mother Seton was placed on lock down after a vehicle chase that resulted in an overturned car and an individual being ejected. Two individuals fled the scene towards the school, resulting in it entering lock down status. The individuals were apprehended without incident. This event led to a series of schools in Central New Jersey updating security measures, including Mother Seton Regional High School. Mother Seton saw increased security measures and updated policies, with further discussion alongside the Archdiocese of Newark on future protocols. That same year, students and faculty participated in a nationwide protest against gun violence, honoring the 17 victims of the Marjory Stoneman Douglas High School shooting in Parkland, Florida. Mother Seton students attended a rally involving a video from Cardinal Tobin. After this, students proceeded outside and gathered in prayer around a statue of Saint Elizabeth Anne Seton. This service included the Prayer of Saint Francis of Assisi and reflections on Psalm Prayers. This even was supported and planned by the Archdiocese of Newark.