In late June, the regiment moved to the Virginia Peninsula and became part of the 2nd Brigade, 2nd Division, 1st Corps, Pope's Army of Virginia until July 1862. The regiment saw considerable action during the Northern Virginia Campaign in the late summer, and was engaged in skirmishing during the Second Bull Run operations. As part of the Army of the Potomac, the 6th Ohio Cavalry participated in the Fredericksburg operations in November–December 1862. It subsequently went into winter quarters, guarding the Rappahannock River.