In June 2007, The Sabin Vaccine Institute, named Milano a Founding Ambassador for the Global Network for Neglected Tropical Diseases, an alliance formed to advocate and mobilize resources in the fight to control neglected tropical diseases (NTDs), to which Milano donated US$250,000. She is also a UNICEF Goodwill Ambassador for the United States of America, Her field work for the organization has included a 2004 trip to Angola to speak with HIV-positive women and people disfigured by land mines during the country's civil war; a trip to India to meet displaced mothers living in squalor following the 2004 tsunami; and a 2010 trip to the settlement of Kolonia in western Kosovo to witness impoverished living conditions. Milano wrote on her blog that the latter trip was "the hardest experience I've had on a field visit", and described a waste dump close to the settlement where children spent time looking for metal to sell or scavenging for food.