Spiridonova was out for the majority of the season due to a comminuted ankle fracture she sustained in late 2018. In August she returned to competition at the Russian Cup where she only competed on uneven bars and balance beam. She won gold on uneven bars, finishing ahead of 2019 Junior World Uneven Bars Champion Vladislava Urazova and 2019 European Games Uneven Bar Champion Angelina Melnikova. Shortly after the conclusion of the Russian Cup Spiridonova was named to the nominative team for the 2019 World Championships alongside Melnikova, Lilia Akhaimova, Angelina Simakova (later replaced by Maria Paseka), Anastasia Agafonova, and Aleksandra Shchekoldina.