In late April 1918, the regiment joined an attack on Es Salt, which was undertaken as part of a plan to capture the village so it could be used as a staging point for a further advance towards the railway junction at Deraa. The regiment's role in the raid was to advance up the eastern side of the Jordan River to capture a crossing to the north of Es Salt at Jisr ed Damieh to stop Ottoman reinforcements being sent to Es Salt from Nablus. Initially, the operation met with success, and although two of the 12th's squadrons met strong resistance and were stopped at the bridge on the Es Salt track, the village was secured by dusk on 30 April by troops of the 3rd Light Horse Brigade. Throughout the night, the 4th Light Horse Brigade assumed defensive positions: the 12th in the centre with the 4th on their left and the 11th on their right. The following day, they were confronted by a force of around 4,000 Ottoman infantry along the Es Salt track, while another force of 1,000 infantry and 500 cavalry were further south, ready to force a second crossing. After coming under attack, and finding themselves hard pressed, the 4th Light Horse Brigade was forced back to the south, exposing the rear of the troops holding Es Salt. Over the course of next few days little progress was made by the British Empire troops and, despite the arrival of reinforcements, the commander of the operation, Lieutenant General Harry Chauvel, decided that it was necessary to withdraw from the position on 3 May. The regiment crossed the Jordan and two days later had returned to its previous positions around Jericho.