A second season-long loan to Roma was agreed by Arsenal, ahead of the 2016–17 season. During the summer of 2016, Roma also signed Brazilian goalkeeper Alisson from Internacional, meaning that Szczęsny would face competition for a starting spot in the team. In his second season in the Italian capital, Szczęsny kept the most clean sheets in Serie A (14), helping Roma to set a club seasonal record of 87 points, and earn a second-place finish in the league. In total, he made 72 appearances in Serie A over the course of his two seasons with Roma.