His brothers were Tadeusz Manteuffel and Edward Manteuffel-Szoege. He graduated from the Warsaw University under the supervision of Zygmunt Radliński. During the II World War he worked in conspiracy under the pseudonym "Krab" (literally Crab). For the whole German occupation he worked in clinic. Manteuffel-Szoege was one of three physicians who survived the Wola massacre.