In 1796, Despinoy joined Bonaparte's Army of Italy and fought at the Battle of Mondovì. Promoted to general of division in June 1796, he directed the siege of the citadel of Milan until its surrender. Bonaparte removed him from the command of his division "for refusing to engage the Austrians on 3 August" during the Battle of Lonato. On 14 August 1796, Bonaparte wrote of him, Without energy or audacity. Is not a natural soldier, is not loved by his men, does not lead them into action. Has high principles, a good mind, sound political views. A good commander in the interior."