After a break from the sport, she returned a few years later to run at the 2010 Commonwealth Games in New Delhi. She reached the women's 100 m final and came away with the Commonwealth gold medal after a chaotic series of events: A dual false start by Laura Turner and Sally Pearson, saw just Turner eliminated and Mayers finished third for the bronze medal behind Pearson and Oludamola Osayomi. Pearson was then disqualified on appeal, meaning Mayers was elevated to the silver medal behind Osayomi. However, the placings changed yet again as the Nigerian winner was disqualified after failing a drugs test, leaving Mayers as the event winner. This made her the first woman to win at the Commonwealth Games for Saint Vincent and Grenadines, the country's only medallist at the Games, and only their second gold medallist ever after Frankie Lucas's middleweight title at the 1974 edition.