In the postseason, Price started Game 2 of the Division Series against the New York Yankees. He allowed three runs on three hits and was removed after innings, taking the loss. This was the tenth postseason game that Price had started during his career, all ten of which had resulted in losses for his teams. Price's next postseason start was Game 2 of the Championship Series against the Houston Astros, which the Red Sox won, 7–5, with Price allowing four runs, five hits, and four walks in innings; he received a no decision as he did not complete the fifth inning. When Chris Sale became unavailable to start Game 5 of that series for health reasons, Price was called on to start again on only three days' rest, and earned the win, holding Houston scoreless through six innings while allowing just three hits and striking out nine. Winning 4–1, the Red Sox clinched their first trip to the World Series since 2013. It was Price's first win in 12 career postseason starts, and his third postseason win overall; the two earlier wins had been earned in relief during the 2008 ALCS and 2015 ALDS.