During Latham's final year at Indiana, he played in 11 of 12 games. He would finish the 2015 season second on the team with four sacks (22 yards) and third on the team with 10 tackles for loss (35 yards). Additionally, he would record a total of 33 tackles, 16 solo, one interception, one pass breakup and two blocked kicks. Latham would finish the 2015 season receiving Honorable mention for the All-Big Ten team (coaches). On December 30, 2015, Latham declared his intention to enter the NFL Draft.