During his run on "Thirtysomething", "People" magazine named him one of the "50 Most Beautiful People". Horton acted in television shows including "St. Elsewhere", "The White Shadow", "Dallas", "Eight Is Enough", "In Treatment" and "The Geena Davis Show", played the lead in the short-lived series "Brimstone", and played Crane McFadden in the one season series (1982–1983) "Seven Brides for Seven Brothers". He played Jacob in the 1982 feature film "Split Image", Father Mahoney in the 1986 feature film "Where the River Runs Black" Roy Fox in the 1996 film "Two Days In The Valley" and played Burt in the 1984 Stephen King movie "Children of the Corn". He had a minor role in Cameron Crowe's Seattle romantic comedy, "Singles". He played Harry Landers in the "Hospital" skit from "Amazon Women on the Moon" opposite wife Michelle Pfeiffer, whom he had previously directed in the ABC Afterschool Special "One Too Many" in 1985. Horton also appeared in the 1997 TV movie version of the Jon Krakauer book "", playing Scott Fischer, the leader of the disastrous 1996 climb on Mount Everest. He was also in the movie "Sideout" (1990) as Zach Barnes, a down and out ex-volleyball champ. As a director he has worked on several television series including "The Shield", "Thirtysomething", "The Wonder Years", "Once and Again", and directed the pilot for "Grey's Anatomy" as well as pilots for "Class of '96", "Birdland", "Dirty Sexy Money", "The Philanthropist" and "Reconstruction". He directed the 1990 film for television "Extreme Close-up" as well as the 1995 feature film "The Cure". As a producer he produced "Reconstruction" (which he co-created), "Lone Star", "The Philanthropist", "The Body Politic" (which he also co-created), "Grey's Anatomy", "Six Degrees" and "Murder Live" (for which he wrote the story).