Powel corresponded widely, including with the political elite of the time. She was a close friend and confidante to George Washington and was among those who convinced him to continue for a second term as president. She wrote extensively, but privately, on a wide range of subjects, including politics, the role of women, medicine, education, and philosophy. Powel is said to be the person who asked Benjamin Franklin, "What have we got, a republic or a monarchy?", to which he reportedly replied, "A republic... if you can keep it", an often quoted statement about the Constitution of the United States. The exchange was first recorded by James McHenry, a delegate of the Constitutional Convention, in his journal entry dated September 18, 1787. Powel's exchange with Franklin was adapted over time, with the role played by Powel all but removed in 20th-century versions and replaced with an anonymous "lady", "woman", or "concerned citizen". The setting of the conversation was also revised from her home at the Powel House to the steps of Independence Hall.