Jagannathan has appeared on several TV shows like "Big Little Lies", "Better Call Saul" and "Ramy". She played Blacklister #44 on "The Blacklist", and appeared as the guest lead on "" for their 18th year's double-season-finale episodes. In 2017, she played one of the leads in A24's film "Share". "Share" premiered at the 2019 Sundance Film Festival, winning Best Screenplay and Best Actor, and was immediately acquired by HBO.