During World War I, "Vendetta" participated in the Second Battle of Heligoland Bight, and operated against Bolshevik forces during the British Baltic Campaign. Most of the ship's post-war career was spent operating in the Mediterranean. In 1933, "Vendetta" was one of five destroyers selected for transfer to the RAN. Over the next six years, the ship was either involved in peacetime activities or was in reserve, but when World War II started, she was assigned to the Mediterranean as part of the 'Scrap Iron Flotilla'. During the Greek Campaign, "Vendetta" was involved in the transportation of Allied troops to Greece, then the evacuation to Crete. After, the destroyer served with the Tobruk Ferry Service, and made the highest number of runs to the besieged city of Tobruk.