Presutti provided initial coverage following the 2013 Boston Marathon bombing, returning to report on the event's first anniversary. In 2014, she partnered with a cappella group, Pentatonix, to cover the first use of Google Glass at a professional concert. Presutti covered Hillary Clinton's headquarters and concession speech after the candidate's 2016 presidential election loss. In 2019, she led the US coverage of the agency-wide project, The Worth of a Girl, which won numerous national and international awards. Presutti covered the 2020 election and Joe Biden's acceptance speech in Wilmington, Delaware.