In , Lohse's first full year as a starter, he posted a 13–8 record with an ERA of 4.23. He followed that with success in , starting 33 games and going 14–11 with a 4.61 ERA. In , he did not fare as well, going 9–13 with a 5.34 ERA. Lohse has been to one ALCS, with the Twins in 2002.