He also scored in the first league game of the season, against Genoa on 25 August; his goal came in injury time, giving Inter a 2–0 win, which was followed by another goal and an assist in a 3–0 win against Catania. On 20 October, Palacio scored twice to give Inter a 3–3 draw against Torino at the Stadio Olimpico, and six days later scored in a 4–2 triumph against recently promoted Hellas Verona at San Siro. On 3 November, Palacio continued his fine form, scoring a header and assisting in a 0–3 away win against Udinese at the Stadio Friuli. On 22 December, he scored a superb goal in the 86th minute with the back of his heel after an assist from Fredy Guarín, which proved to be decisive with Inter winning 1–0 against Milan. That was his first competitive goal in the "Derby della Madonnina".