In the 2015–16 season. Yuskov opened his season winning the 1500 m gold at the 2015–16 ISU Speed Skating World Cup in Calgary, setting a new personal record clocking a time of 1:41.88. He then competed at the Inzell World Cup in Germany winning gold in men's 1500 m and a silver in 1000 m behind Dutch speed skater Kjeld Nuis. At the 2015–16 ISU World Cup in Heerenveen, Yuskov won 2 silver medals in 1000 m behind teammate Pavel Kulizhnikov and in 1500 m behind American Joey Mantia. In December 2015, he repeated as the allround champion at the 2016 Russian Nationals. On 9–10 January, Yuskov competed at the 2016 European Speed Skating Championships in Minsk where he placed first in men's 500 m and 1500 m however he was unable to finish the allaround events, as he later withdrew in men's 10000 m because of a minor groin injury. He returned to competition in 29–31 January at the ISU World Cup in Stavanger where he won gold in 1500 and bronze in 1000 m. On 11–14 February, At the 2016 World Single Distance Speed Skating Championships in Kolomna, Yuskov won the gold in men's 1500 m and silver in men's 1000 m behind teammate Pavel Kulizhnikov.