"Centurion" was paid off in 1752, and underwent another Middling Repair, this time at Chatham, between October 1752 and August 1753. She was recommissioned in October 1754 under the command of Captain William Mantell, this time serving as the flagship of her old commander, Commodore Augustus Keppel. She sailed to Virginia in 1754, and then to Nova Scotia in 1756, before returning to Britain. She sailed again for North America in April 1757, and was present at the Siege of Louisbourg in 1758, followed by the assault on Quebec in 1759. She underwent another survey in 1760, before passing that year under the command of Captain James Galbraith. She sailed to Jamaica in 1760, where she spent time as the flagship of Sir James Douglas. She was active in the operations against Havana in the summer of 1762, after which she was again paid off.