In May 2019, Filipe Luís was included in the 23-man squad for the 2019 Copa América on home soil. In the quarter-final match against Paraguay on 27 June, he was replaced by Alex Sandro at half-time after suffering an injury, as his team advanced to the next stage after winning 4–3 on penalties; they subsequently went on to win the title, following a 3–1 win over Peru in the final at the Maracanã Stadium.