In late March 1864, the 10th Missouri Infantry was assigned to a brigade commanded by Colonel Simon P. Burns in a division commanded by Parsons. In early April, a Union army under command of Major General Nathaniel P. Banks began moving towards Shreveport, Louisiana, in the Red River Campaign. On April 9, Burns' Brigade joined the command of Major General Richard Taylor at Pleasant Hill, Louisiana. Later that day, the regiment participated in the Battle of Pleasant Hill. Parsons' division, which was on the right flank of the Confederate line, attacked the Union line. The attack was initially successful, driving in part of the Union line, but a Union counterattack defeated the Confederates. The Confederates retreated in some disarray. The Union force abandoned the field after the battle. At Pleasant Hill, the regiment lost 10 men killed and 25 wounded, for a total of 35.