The competition was contested in two-legged home-and-away format between Brazilian team Palmeiras, the 2020 Copa Libertadores champions, and Argentine team Defensa y Justicia, the 2020 Copa Sudamericana champions. The first leg was hosted by Defensa y Justicia on 7 April 2021, while the second leg was hosted by Palmeiras on 14 April 2021. The matches were originally scheduled for 10 February 2021 and 3 March 2021, but were rescheduled due to the participation of Palmeiras in the 2020 FIFA Club World Cup.