During his rookie season with the Jets, Scheifele played for the senior Canadian team at the 2014 IIHF World Championship in Minsk. However, they failed to medal at the tournament after being eliminated by Finland in the quarter-finals. He was later named to Team Canada's 2016 IIHF World Championship roster, held in Moscow and Saint Petersburg, where he won the gold medal. Following this, Scheifele was named Kitchener-Waterloo and area's top athlete for 2016. Later that year, Scheifele represented Team North America at the 2016 World Cup of Hockey, playing on the top line alongside Auston Matthews and Connor McDavid. In 2019, Scheifele announced his decision to skip the 2019 IIHF World Championship after the Jets were eliminated from the Stanley Cup playoffs.