On 30 June 2019, Luca Pellegrini joined Serie A champions Juventus for €22 million, with Leonardo Spinazzola moving in the opposite direction for €29.5 million. On 19 August 2019, he rejoined Cagliari on loan for the 2019–20 season. On 26 September 2020, Pellegrini moved to Genoa on a one-year loan.