On June 21, 2011, Moreland hit his first career walk-off home run off of Enerio Del Rosario of the Houston Astros. For the 2011 season, Moreland batted .259 with 16 home runs and 51 RBIs in 134 games played. The Rangers were in the World Series for the second season in a row; Moreland had one home run during the Series against the St. Louis Cardinals, which the Rangers lost in seven games.