On January 18, 2016, Pederson was hired as head coach of the Eagles replacing Chip Kelly. Despite having Sam Bradford on the roster as the starting quarterback, the Eagles drafted Carson Wentz with the second overall pick in 2016. Right before the 2016 season began, Bradford was traded to the Minnesota Vikings and Wentz was named the starting quarterback as a rookie. Pederson and Wentz won their first three NFL games together, but finished the season 7–9, missing the playoffs.