In 1964, Liscio started 10 games before being placed on the injured reserve list with a right knee injury. He lost all of the 1965 season after suffering complications (staph infection) from an offseason knee surgery. In 1966, he recovered enough to resume his career, was named starting left guard (10 starts), and eventually moved back to left tackle (four starts) at the end of the season. The next year, he played in the 1967 NFL Championship Game, famously known as the "Ice Bowl". In 1970, he played in only 11 games (seven starts) because of back problems.