Gilardino has played for several Italian clubs throughout his career. He first came to prominence during his time at Parma due to his consistent goalscoring, which earned him the Serie A Young Footballer of the Year Award in 2004, followed by the Serie A Footballer of the Year and the Serie A Italian Footballer of the Year Awards in 2005, as well as a move to AC Milan. With Milan, he won the 2006–07 UEFA Champions League, the 2007 UEFA Super Cup and the 2007 FIFA Club World Cup. Gilardino has also played for Chinese club Guangzhou Evergrande, with whom he won the 2014 Chinese Super League.