The New Jersey Nets selected him in the second round of the 2001 NBA draft. The Nets made consecutive NBA Finals his first two years, and Scalabrine played four seasons with the team. In 2005, he signed with the Boston Celtics and won a championship with the team in 2008. The Celtics also appeared in the 2010 NBA Finals. Scalabrine signed with the Chicago Bulls the following season, and played with them until 2012. Throughout his NBA career, Scalabrine served as a backup power forward.