In June 2021, Chiesa was included in Italy's squad for UEFA Euro 2020. He was named Man of the Match by UEFA in Italy's final group match, a 1–0 victory over Wales in Rome on 20 June, which saw them top their group. On 26 June, he scored the opening goal in a 2–1 extra-time win over Austria in the round of 16 of the tournament at Wembley Stadium. His father Enrico had scored 25 years and 12 days earlier in Italy's second group match at UEFA Euro 1996 in England, a 2–1 loss against eventual runners-up Czech Republic; as such they became the first father and son pair to have scored a goal at the Euros. In the semi-final against Spain on 6 July, he scored the opening goal in a 1–1 draw; a game in which Italy advanced to the final of the tournament after extra time following a 4–2 penalty shoot-out victory. For his performance, Chiesa was named Man of the Match by UEFA for the second time. On 11 July, Chiesa suffered an injury late in the second half of regulation time in the UEFA Euro 2020 Final against England at Wembley Stadium, and was subsequently replaced by Federico Bernardeschi in the 86th minute; Italy went on to win the European Championship following a 3–2 victory in a penalty shoot-out after a 1–1 draw in extra-time. For his performances throughout the competition, he was named in the "Team of the Tournament".