On 14 May 2019, Roma announced that they would not renew De Rossi's contract, and that he will leave the club at the end of the 2018–19 season, after 18 seasons with the team. He made his 616th and final appearance for the club on 26 May in a 2–1 home win over Parma, making him the club's second-most capped player of all time, after Totti.