Grace placed 5th in 4:22.7 at 2016 Fifth Avenue Mile. Grace improved her personal best time to 1:58.28 at Weltklasse Zürich of 2016 IAAF Diamond League in a fifth-place finish. Grace placed eighth in the final of Athletics at the 2016 Summer Olympics – Women's 800 metres. Grace placed first in 800 m ahead of Team USA teammates Ajee' Wilson and Chrishuna Williams at 2016 United States Olympic Trials (track and field) and represented USA at Athletics at the 2016 Summer Olympics. Grace won 4:05.65 at 2016 Hoka One One Mid Distance Classic May 20 at Occidental College a week after running 2:00.05 in the Portland Rain 2016 Portland Twilight women 800 meters.