Spearman sought re-election in 2016, when her first term ended. She was challenged by Republican Arsen Ter-Petrosyan, who had never run for office before. During the campaign season, Spearman supported presidential candidate Hillary Clinton, and held a speech at the Democratic National Convention on July 25, talking about LGBT rights, and saying how the Republican presidential ticket would threaten those rights. During her own campaign, Spearman said schools had to adapt to the available career opportunities. Moreover, she supported Ballot Question 2, a voter initiative to legalize cannabis. During a council meeting of the League of Women Voters of Las Vegas, she said she would introduce bills concerning equal pay, the ratification of the Equal Rights Amendment, and voter registration. She won the election, that was held on November 8, with 65% of the votes. She had raised over $235,000.