Ophelia S. Lewis published her first book, titled "My Dear Liberia", a memoir of pre-civil war Liberia, in 2004. Next she published a book of poems, a collection of short stories, a series of children's books and a novel. Lewis was an officiating member of the Liberian Writers Network during its formation in 2005. She has been featured in scholarly publications such as "Thinking Classroom: An International Journal of Reading, Writing and Critical Reflections" and "Sea Breeze: A Journal of Contemporary Liberian Writings".