The brigade was quickly raised again on the eve of the Second Italian War of Independence in 1859 as II Cuirassier Brigade and consisted of the cuirassier regiments "Savoia Cavalleria" and "Genova Cavalleria". Together with the I Cuirassier Brigade with the regiments "Nizza Cavalleria" and "Piemonte Reale Cavalleria" the brigade formed the army's cavalry division. The brigade fought in the battles of Palestro and . After the war the brigade was garrisoned in Milan with its regiments in Turin and Vigevano. In 1863 the brigade was once more disbanded.