Some of MacKinnon's images have received wider attention, sometimes beyond Canada's borders. In 2014, after a reservist on ceremonial sentry duty at the nation's National War Memorial was killed by a shooter who then broke into the parliament building and had a gun battle with security, MacKinnon depicted the bronze World War I soldiers of the memorial extending their hands to the murdered man. In response to the Las Vegas mass shooting, MacKinnon drew a cartoon depicting Uncle Sam using his body to shield a spokesman for the National Rifle Association and reassuringly saying, "Everything's okay... you're safe..." while they are surrounded by the sprawled, bloody corpses of the shooting victims. That cartoon was widely shared in 2017, and again in 2018 following other gun attacks. After the Parkland High School shooting, the cartoon was shared over 600,000 times on Facebook and was retweeted over a million times by Twitter users, including Mark Hamill, Steven Van Zandt and Ron Perlman. In 2018, during the confirmation hearings for U.S. Supreme Court nominee Brett Kavanaugh that included a contentious sexual assault investigation, MacKinnon drew a cartoon showing Lady Justice being violently pinned to the floor and having her mouth covered by the hands of Republican men, mimicking the account of Christine Blasey Ford. The image was profusely shared, and also appeared on protest signs.