At the end of the preceding Pliocene, the previously isolated North and South American continents were joined by the Isthmus of Panama, causing a faunal interchange between the two regions and changing ocean circulation patterns, with the onset of glaciation in the Northern Hemisphere occurring around 2.7 million years ago. During the Early Pleistocene (2.58–0.8 Ma), archaic humans of the genus "Homo" originated in Africa and spread throughout Afro-Eurasia. The end of the Early Pleistocene is marked by the Mid-Pleistocene Transition, with the cyclicity of glacial cycles changing from 41,000 year cycles to 100,000 year cycles. The Late Pleistocene witnessed the spread of modern humans outside of Africa as well as the extinction of all other human species. Humans also spread to the Australian continent and the Americas for the first time, co-incident with the extinction of most large bodied animals in these regions.