Byrne has a history of supporting gun rights. He voted against universal background check legislation for gun sales, and against a measure to grant law enforcement additional time to run background checks for gun sales. In 2015, Byrne co-sponsored legislature to allow cross-state concealed carry. In 2019, he hosted a town hall meeting at a gun store, three days after the Dayton mass shooting, which killed 9 people. During the meeting, Byrne said that red flag laws violate the Second Amendment and are not effective.