In the first half of 2016, Donaldson resumed the high level of play from his MVP season. He won the June 19 Player of the Week Award after hitting three home runs, four doubles, one triple and nine runs driven in with 12 hits in 27 at bats. He led the league in total bases (27), extra-base hits (8) and tied for first in slugging percentage (1.000). On July 7, he was announced as a reserve for the American League in the 2016 All-Star Game. Heading into the All-Star break, Donaldson was batting .304 with 23 home runs and 63 RBIs. He had also scored 80 runs, which made him the first player in Blue Jays history to do so before the All-Star break. On August 28, Donaldson hit three home runs in a game for the first time in his career, leading the Blue Jays to a 9–6 win and a sweep of the Minnesota Twins. Donaldson finished the 2016 regular season with a .284 batting average, 37 home runs, and 99 RBI.