"Henry B. Wilson" served as plane guard for carriers on Yankee Station in the Tonkin Gulf, participated in Sea Dragon operations, patrolled on search and rescue duties and carried out naval gunfire support missions during the Vietnam War. In April 1975, she participated in Operation Eagle Pull (the evacuation of Phnom Penh, Cambodia) and in May 1975 she participated in Operation Frequent Wind (the evacuation of South Viet Nam) where part of her duties was to protect the ships loading evacuees by drawing fire from the shore batteries. During the same month she was one of the primaries in the operation to recapture the hijacked merchant ship in Cambodian waters.