Clarke has called for immigration reform that would create a path to citizenship for undocumented immigrants living in the United States and direct resources away from enforcement. In 2010, she voted for the DREAM Act, which passed the House but was blocked in the Senate. Clarke has voted against legislative proposals to constrain immigration. She praised the Obama administration's DACA program and condemned the Trump administration's termination of the program, calling it "cruel and vindictive." She has also called for extending the Temporary Protected Status granted to Haitian immigrants seeking refuge after the 2010 earthquake in Haiti, and for the abolition of ICE.