Henderson spent the 2017–18 season as a first-team regular, on 23 September 2017 he scored his only goal of the season, a winner against Leicester City in a 3–2 win. On 15 August 2017 Henderson captained Liverpool for the first time in the Champions League against German side Hoffenheim. He would go on to captain Liverpool all the way to the final, ending up on the losing side after Liverpool were beaten 3–1 by Real Madrid in Kiev. Henderson ended the 2017–18 season with 41 appearances in all competitions, scoring 1 goal.