On November 3, 1941, "Corallo" under command of captain Andreani was deployed west of Malta as a protective screen for a large Italian "Beta" convoy travelling to Libya. Her job was to detect and report any British naval movements west of Malta, and attack the sighted ships when possible. On November 9, 1941, the "Beta" convoy was intercepted and destroyed by British Force K in the Battle of the Duisburg Convoy. Force K managed to leave Malta without "Corallo" being able to detect it since it did not pass through her area of operation, but rather through the one controlled by . At sunset, the submarine left her assigned area and moved to her new area of operations off Algeria and Tunisia.