On 2 January 2021, Pochettino was appointed as the head coach of Paris Saint-Germain on a 18-month contract, where he had spent two years during his playing career. He replaced Thomas Tuchel. His first match in charge was four days later, a 1–1 away league draw against Saint-Étienne. On 9 January, Pochettino won his first game in a 3–0 home win over Brest. Four days later, he won the first honour of his managerial career as Paris Saint-Germain defeated rivals Marseille with a 2–1 victory in the Trophée des Champions. On 16 February 2021, Pochettino took charge of his first Champions League match with the Parisians, guiding them to a 4–1 win over Barcelona at the Camp Nou in the first leg of the round of 16 tie. This marked Pochettino's first European victory as Paris Saint-Germain coach. In the Champions League quarter-finals, PSG won against the title holders Bayern Munich on the away goal rule, due to a 3–2 away victory at the Allianz Arena. However, PSG lost in both legs in the semi-finals against Manchester City. Pochettino finished the season with a win in the Coupe de France Final against Monaco, and in second place in the Ligue 1 behind Lille. In July 2021, he extended his contract until 2023.