In June 1423 at Troyes, Anne married John of Lancaster, 1st Duke of Bedford, son of Henry IV of England, a marriage agreed by the terms of the 1423 Treaty of Amiens. The marriage was meant to cement relations between England and Anne's brother Philip the Good, Duke of Burgundy. This alliance was vital for continued English success in France as, in 1422, John had been appointed Regent of France, during the minority of his nephew, Henry VI of England, who was seven months old at the death of his father on 31 August 1422. Burgundy's antagonism towards the House of Valois (which caused the Armagnac–Burgundian Civil War) had been one of the leading factors in the losses faced by the French at the hands of the English. John and Anne were happily married. Their union remained childless.