Operation Uzice was the first major counter-insurgency operation by the German Wehrmacht on the occupied territory of the Kingdom of Yugoslavia. The operation was directed against the Užice Republic, the first of several "free territories" liberated by the Yugoslav Partisans. It was named after the town of Užice, and is associated with the First Enemy Offensive () in Yugoslavian historiography. The security forces of the German-installed puppet regime of Milan Nedić also participated in the offensive.