During Germany's successful title defence at the 2007 FIFA Women's World Cup, Garefrekes was part of the team's starting line-up in all of the six matches. She scored twice, including the opener in the quarter-final victory against North Korea. Garefrekes again claimed bronze at the 2008 Summer Olympics and won the European Championship for a second time in 2009. She has been called up for Germany's 2011 FIFA Women's World Cup squad. A few months before the start of the World Cup, she scored a hat trick in a friendly match against Nigeria. Following the tournament she retired from international play.