Dating from the end of the 15th century to 1623 the village was owned by Okunia family and the Mokrowski family. In 1522 Grodzisk Mazowiecki has received Municipal Rights from king Zygmunt (Sigismund) I Old. In 1540 Grodzisk was destroyed by the fire and was not reconstructed until the end of 16th century. After the reconstruction, Grodzisk Mazowiecki became a local trade and production centre due to its location and the local traffic routes. In 1655 it was again destroyed during Swedish Deluge and then restored. In 1708 the town was struck by a cholera epidemic and as a result its population diminished down to 370 people. During the November Uprising (1830–1831) the town was the place of fights between the insurrectionists’ forces and Russian army. The recovery of the local economy was possible to the prosperous railway route connecting Warsaw and Skierniewice built in 1846. In 1870 the town's municipal rights were taken away. Between the 19th and 20th century Grodzisk was known as recreation center with hydropathic establishment founded by . In 1915 Grodzisk regained its municipal rights