On 31 August 2010, he moved to English Premier League club Birmingham City, signing a one-year deal, having rejected offers from a variety of clubs. Jiránek made his debut in the starting eleven for the League Cup third-round match against MK Dons, and had a good chance to score as Birmingham won 3–1. His second start came in a tidy performance as several first-team regulars were rested for the FA Cup third round tie against Millwall which Birmingham won 4–1. After Scott Dann was injured in the first leg of the League Cup semi-final against West Ham United, Jiránek became a regular starter, and he was in the starting eleven as Birmingham beat favourites Arsenal 2–1 in the League Cup Final at Wembley Stadium. A toe injury that eventually required surgery disrupted the latter part of his season, and following Birmingham's relegation from the Premier League, he rejected the option of another season with the club.