The Ghisi family was a Venetian noble family, originally from Padua or Aquileia. Following the establishment of Crusader states in Greece after the Fourth Crusade, the Ghisi became an important dynasty there. Andrea Ghisi became lord of the islands of Tinos and Mykonos, while his brother Geremia Ghisi became ruler of Skopelos, Skiathos, and Skyros. Later members of the family were also active in the Principality of Achaea and the Triarchy of Negroponte.