Retained by new head coach Andy Farrell in his squad for the 2020 Six Nations Championship, Stander started in Ireland's 19–12 opening win against Scotland on 1 February 2020, their 24–14 win against defending champions Wales on 8 February, and their 24–12 defeat against England, before the tournament was suspended due to the COVID-19 pandemic. The tournament eventually resumed in October 2020, with Stander starting and scoring a try in Ireland's 50–17 win against Italy and starting in the 35–27 defeat against France in their final fixture of the tournament. Stander was nominated for the 2020 Six Nations "Player of the Championship".