Karen Serobi Demirchyan (; 17 April 1932 – 27 October 1999) was a Soviet and Armenian politician. He served as the First Secretary of the Armenian Soviet Socialist Republic from 1974 to 1988. Soon after his reemergence into active politics in independent Armenia in the late 1990s, he became President of the National Assembly in 1999 until his assassination with other politicians in parliament in the Armenian parliament shooting.