Kaseba announced her candidacy for President of Zambia shortly after her husband's death. She filed her nomination papers on November 18, 2014, to contest the January 2015 presidential by-election as a member of Sata's Patriotic Front (PF). Kaseba was one of nine to compete for the PF nomination for president. However, Kaseba and the other seven PF candidates lost their party's nomination to Edgar Lungu at the party's November general conference.