During the civil wars of the 14th century, the Tagaris family were loyalists. Manuel supported the reigning emperor against his upstart grandson during the civil war of 1321–1328 and George supported the Emperor John V Palaiologos against the rebel John Kantakouzenos during the civil war of 1341–1347. On foreign policy the family favoured close ties with the Catholic powers of the West. George seems to have converted to Catholicism late in life. His brother Paul was a Catholic prelate for a time.