In 2008 Tramuto founded Physicians Interactive Holdings, which provided mobile and Web-based medical reference tools, electronic drug sampling, and interactive education to the healthcare industry. Venture capital was supplied by Perseus, a private equity firm. The company's proprietary technology could be used to transmit a patient's medical data to a physician through a handheld device. After the 2010 earthquake in Haiti, physicians there used it to communicate with medical experts in the U.S.