In June 2021, Bernardeschi was included in Italy's squad for UEFA Euro 2020 by manager Roberto Mancini. On 6 July, following a 1–1 draw after extra-time against Spain in the semi-final of the competition, Bernardeschi converted his spot-kick in an eventual 4–2 penalty shoot-out victory, to send Italy to the final. On 11 July, Bernardeschi won the European Championship with Italy following a 3–2 penalty shoot-out victory over England at Wembley Stadium in the final, after a 1–1 draw in extra-time; during the match, he replaced the injured Federico Chiesa late on in the second half, towards the end of regulation time, and later scored Italy's fourth spot-kick in the shoot-out.