He begun the new season on 21 August by winning the 2010 Supercoppa Italiana under Rafael Benítez, scoring the equalizer versus Roma in an eventual 3–1 home win for the first silverware of the season. Six days later, he made an appearance as substitute as Inter lost the 2010 UEFA Super Cup to Atlético Madrid. Later in December 2010, Pandev was part of the team that competed at 2010 FIFA Club World Cup. He made his debut in the competition by playing full-90 minutes in the 3–0 win versus Seongnam Ilhwa Chunma in the semi-final. On 18 December, in the final against Congo's TP Mazembe, Pandev netted inside 13 minutes to make it his first goal in a major final as Inter won 3–0 to lift the trophy. On 15 March 2011, in the second leg of 2010–11 UEFA Champions League round of 16 tie against Bayern Munich, Pandev resulted decisive by scoring in the 88th minute following a Samuel Eto'o pass to make it 3–2 for Inter. Inter progressed to the quarter-finals on away goals rule, with Pandev describing his goal as the "most important" of his career. Later on 29 May 2011, in the 2011 Coppa Italia Final match against Palermo, Pandev entered in the second half and provided the assist of Diego Milito goal in the 92nd minute for a 3–1 success. This turned out to be his last appearance for the club as he was removed during the summer transfer window.