On 27 November 1961 "Mazama" again recommissioned. Home ported at Mayport, Florida for the next four years, she participated in fleet exercises along the Atlantic seaboard and in the Caribbean. During fall 1962 exercises in the latter area she was called on to support the ships enforcing the Cuban quarantine. In 1964 she was again deployed to the Mediterranean, where during a rearming of the Roosevelt CVA 42 and the USS "Mazama" AE 9 there was a collision, only one sailor was injured, Seaman Albert with a concussion during the collision. There was severe damage to the Mazama and she was transported to Roto Spain for repairs. During the month of August, she stood by in support of the Cyprus patrol as civil unrest and fighting between Greek and Turkish Cypriots threatened an uneasy peace in the eastern Mediterranean.