In 1810, he was appointed the commander of the 1st Cuirassier Division, which at the beginning of the Patriotic War of 1812 was part of the 1st Western Army. In this capacity, Depreradovich participated in the Patriotic War of 1812 and foreign campaigns. On 30 August 1813, he was promoted to the rank of lieutenant general. Depreradovich especially distinguished himself in the battles of Kulm and Fère-Champenoise. At Fère-Champenoise, it was Depreradovich's actions that decided the outcome of the battle.