On 7 January 2019, Martino was announced as head coach of the Mexico national team in his return to international management since leaving Argentina in May 2016. On 22 March, Martino won his first match with Mexico with a 3–1 win over Chile in a friendly. Later in the same year, Martino and Mexico won the CONCACAF Gold Cup over rivals the United States in a 1–0 victory, his first national title. But in 2021 Martino lost both 2021 CONCACAF Nations League Final and CONCACAF Gold Cup to the United States.