Rémy began his career playing for a local youth club in his home city of Lyon, before joining the biggest club in the city, Lyon, joining their youth academy. In 2005, he was promoted to the senior team and struggled to establish himself in three seasons under managers Gérard Houllier and Alain Perrin. In 2008, he was loaned out to RC Lens and, after a successful stint, was purchased by Nice ahead of the 2008–09 season. With Nice, Rémy flourished in the lead striker role scoring over 25 goals in his two years with the club. In 2010, after enduring interest from several clubs domestically and abroad, Rémy joined the defending champions Marseille on a five-year contract. He moved abroad for the first time to join Queens Park Rangers in January 2013, but could not prevent their relegation. The following season, he remained in the Premier League on loan at Newcastle United. In the summer of 2014, Rémy signed for Chelsea for a reported £10.5 million, where he won the League Cup and Premier League in his first season. He was sent out on loan to Crystal Palace on 30 August 2016 but returned almost immediately on 10 September 2016 to Chelsea after sustaining an ankle injury.