In 1836 the Kingdom was struck by a cholera epidemic which killed 65,000 in Sicily alone. In the following years the Neapolitan countryside saw sporadic local insurrections. In the 1840s, clandestine political pamphlets circulated, evading censorship. Moreover, in September 1847 an uprising saw insurrectionists crossing from mainland Calabria over to Sicily before government forces were able to suppress them. On 13 January 1848, an open rebellion began in Palermo and demands were made for the reintroduction of the 1812 constitution. King Ferdinand II appointed a liberal prime minister, broke off diplomatic relations with Austria and even declared war on the latter (7 April). Although revolutionaries who had risen in several mainland cities outside Naples shortly after the Sicilians approved of the new measures (April 1848), Sicily continued with her revolution. Faced with these differing reactions to his moves, King Ferdinand, using the Swiss Guard, took the initiative and ordered the suppression of the revolution in Naples (15 May) and by July the mainland was again under royal control and by September, also Messina. Palermo, the revolutionaries' capital and last stronghold, fell to the government some months later on 15 May 1849.