After the Jamaican earthquake of 1692, in which Port Royal was almost completely destroyed, Rose travelled to London. He died in 1694 and was buried at St Peter's church, Cornhill, on 29 March 1694. In 1695, his widow Elizabeth Langley Rose took as her second husband Sir Hans Sloane, meaning that her one-third share of the income from Rose's estates ultimately became available to Sloane who received regular shipments of hogsheads of sugar in the following years.