On 10 August 2015, Hernandez renewed his contract until 2019 and was definitively promoted to the main squad. His maiden appearance in the UEFA Champions League took place on 15 March 2016, as he replaced injured Diego Godín for extra time of the round-of-16 tie against PSV Eindhoven (0–0 after 120 minutes, 8–7 penalty shootout win); he entered at the same point in the final, a shootout loss to neighbours Real Madrid in the San Siro on 28 May.