In September 1942, it began transferring to the positions in North Africa at the border with Egypt, finally taking responsibility for the Bardia-Sallum-Naqb al Halfayah defensive line. It failed to hold the positions after the severe British attack, starting 11 November 1942. After a long retreat, it was able to re-establish the defensive line at Mareth, from 4 February 1943. On 6 March 1943, the "Pistoia" division attacked the British positions "en masse" with the goal of disrupting British offensive preparations and trigger a premature counter-offensive, as part of the Battle of Medenine. After the failure of these attacks, the "Pistoia" division fell back to the Mareth Line. When the British started the heavy attack 19 March 1943, it held the positions until 25 March 1943, but then retreated to El Hamma under the threat of being outflanked. The "Pistoia" division was targeted again by British forces on 5 April 1943, and again started to retreat 7 April 1943. By the time it reached Enfidha on 13 April 1943, the division was severely decimated. After a few days, despite some successful counter-attacks at the west of the Takrunah (Takrouna) road junction, the Allies had effectively put "Pistoia" division under siege. The last of its positions were overrun by 13 May 1943.