The pre-inaugural voyage started in St. Nazaire and ended in Genoa. She called in Lisbon (Portugal), Cadiz (Spain), Casablanca (Morocco), Valencia (Spain), and Marseille (France), before arriving in the port of Genoa on March 22. Between winter 2013 and spring 2014, "MSC Preziosa" was operating on South America cruises from Santos. Its destination calls in March 2015 in Tunisia were cancelled due to the terrorist attack in Sousse. In April 2014, it navigated in the Canale della Giudecca, in Venice, Italy. Between March and October, "MSC Preziosa" was scheduled to operate on Mediterranean cruises from Genoa.