In January 2020, Lovato made their first musical appearance since their hiatus with a performance of single "Anyone" at the 62nd Annual Grammy Awards. The song, which was recorded four days prior to their 2018 drug overdose, was released on iTunes immediately after. On February 2, 2020, Lovato performed "The Star-Spangled Banner" at Super Bowl LIV. On March 6, Lovato released a new single titled "I Love Me". The release was supplemented by both a guest appearance and guest-host role on "The Ellen DeGeneres Show". On April 16, they released a collaboration titled "I'm Ready", alongside Sam Smith. A remix of "Lonely Hearts" by JoJo featuring Lovato was released on August 28, 2020. At the 2020 MTV Video Music Awards, Lovato received two nominations for their song "I Love Me", becoming the first artist in VMA history to receive a nomination every year for eight consecutive years. On September 10, Lovato released a collaboration with American DJ, Marshmello, titled "OK Not to Be OK", in partnership with the Hope For The Day suicide prevention movement. On September 30, 2020, they released "Still Have Me" via Twitter. This was later released on digital platforms. On October 14, they released a political ballad titled "Commander in Chief", ahead of the 2020 presidential election. They hosted the 46th People's Choice Awards on November 15, 2020. On November 20, they featured on a song titled "My Reputation" by American rapper, Jeezy, appearing on his album "The Recession 2". On December 4, Lovato featured on a remix of the song "Monsters" by rock band All Time Low, alongside Blackbear.