General Wetherall is most famous for his services during the rebellion in Canada of 1837/38 during which he was the Commander of the Royals' 2nd battalion in the Battle of Saint-Charles, a battle part of the Lower Canada Rebellion fought on 25 November 1837 between Great Britain and Lower Canada Patriote rebels. After the victory, he and his troops unearthed the Colonne de la liberté, a column erected in Saint-Charles by the Patriotes for the Assembly of the Six Counties, and brought it back as a war trophy to Montreal, along with a number of prisoners.