Ghiraldini began his career with Petrarca Rugby in his home town of Padua before moving to Rugby Calvisano in 2005 where, as captain, he won the Super 10 (now Top12) in 2008 and was a runner-up with them in 2006. In 2009, Ghiraldini moved to Benetton Treviso, which joined the Celtic League in 2010.