Kean made his professional debut for Juventus on 19 November 2016, at the age of 16 years, 8 months and 23 days, coming on in the 84th minute for Mario Mandžukić in a 3–0 win over Pescara in Serie A. Upon doing so, he became the club's youngest-ever debutant and the first player born in the 2000s to compete in one of Europe's four major leagues. On 22 November, he became the first player born in the 2000s to feature in a UEFA Champions League match, after being substituted on in the 84th minute of a 3–1 away win over Sevilla. On 27 May 2017, Juventus' final match of the 2016–17 Serie A season, Kean scored his first goal for Juventus, the winning goal of a 2–1 away victory over Bologna, also becoming the first player born in the 2000s to score a goal in one of Europe's five major leagues.