Companies of the Bertie County Regiment were engaged in five known battles and skirmishes: Battle of Brier Creek in Georgia on March 3, 1779, Battle of Stono Ferry in South Carolina on June 20, 1779, Siege of Charleston from March 18 to May 12, 1780, Little Lynches Creek in South Carolina on August 11, 1780, and the Battle of Camden in South Carolina on August 16, 1780.