In 1948, De Mello became the founder-President of the Asian Cricket Conference. He was the president of the Table Tennis Federation of India and a founder of the Table Tennis Federation of Asia. In 1949, he launched the National Sports Club of India, and was an organizer of the 1952 World Table Tennis Championships in Bombay. He was also President of the Bombay Provincial Olympic Association and a key organiser for the 1950 National Games at Bombay.