At the 2021 Russian Championships, Panfilova/Rylov earned their best placement at the senior national championships to date, fifth overall in a field of seasoned senior competitors. The team ranked fourth after the short program, due in part to an uncharacteristic error from Mishina/Galliamov, but fell to fifth in the free skate and fifth overall after a series of errors, including Panfilova falling on a downgraded triple salchow, as well as other underrotation and step-out issues.