After nearly 11 years in reserve at Suisun Bay, "Repose" was recommissioned on 16 October 1965 for service in Vietnam. Arriving on 3 January 1966, she was permanently deployed to Southeast Asia and earned the nickname “Angel of the Orient.” Operating mainly in the I Corps area, she treated over 9,000 battle casualties and 24,000 inpatients while deployed. Notably, USS "Repose" was on station during the 1967 USS "Forrestal" fire that killed 134 sailors and injured 161. Her medical staff also treated legendary marksman Staff Sergeant Carlos Hathcock in September 1969 after he and seven other U.S. Marines suffered extensive burns from an anti-tank mine blast. The "Repose" departed Vietnam 14 March 1970 and was decommissioned in May 1970 and used as a hospital annex for Long Beach Naval Hospital. This proved uneconomical and she was sold for scrap in 1975.