Joining the PNȚ-CD after the 1989 Revolution, Opriş became leader of its youth organization on 1991 (serving until 1993), a junior member of its Leadership Bureau (1991–1995, during the time when the party was headed by Corneliu Coposu) and its Vice President in 1996. As a member of the Chamber, he sat on its Committee for Health and Family throughout his mandates, and advanced legislation on medical practice, the creation of a College of Romanian Doctors, health insurance, and forensic science.