In spring 1466, Sultan Mehmed marched with a large army against Skanderbeg and the Albanians. Skanderbeg had repeatedly sought assistance from Italy, and believed that the ongoing Ottoman–Venetian War (1463–1479) offered a golden opportunity to reassert Albanian independence; for the Venetians, the Albanians provided a useful cover to the Venetian coastal holdings of Durrës () and Shkodër (). The major result of this campaign was the construction of the fortress of Elbasan, allegedly within just 25 days. This strategically sited fortress, at the lowlands near the end of the old "Via Egnatia", cut Albania effectively in half, isolating Skanderbeg's base in the northern highlands from the Venetian holdings in the south. However, following the Sultan's withdrawal Skanderbeg himself spent the winter in Italy, seeking aid. On his return in early 1467, his forces sallied from the highlands, defeated Ballaban Pasha, and lifted the siege of the fortress of Croia (Krujë); they also attacked Elbasan but failed to capture it. Mehmed II responded by marching again against Albania. He energetically pursued the attacks against the Albanian strongholds, while sending detachments to raid the Venetian possessions to keep them isolated. The Ottomans failed again to take Croia, and they failed to subjugate the country. However, the winter brought an outbreak of plague, which would recur annually and sap the strength of the local resistance. Skanderbeg himself died of malaria in the Venetian stronghold of Lissus (Lezhë), ending the ability of Venice to use the Albanian lords for its own advantage. The Albanians were left to their own devices and were gradually subdued over the next decade.