In June 2021, he was included in Italy's squad for UEFA Euro 2020 by manager Roberto Mancini. He made his first and only appearance of the tournament in Italy's final group match against Wales on 20 June, coming on as a late substitute for Gianluigi Donnarumma in the team's 1–0 victory in Rome, which saw them top their group. On 11 July, Sirigu won the European Championship with Italy following a 3–2 penalty shoot-out victory over England at Wembley Stadium in the final, after a 1–1 draw in extra-time.