Adramyttium came under the control of the Attalid dynasty of Pergamon during the rule of Eumenes I, a nominal vassal of the Seleucid Empire, in the mid-third century BC. The alliance between Attalus I, Eumenes's successor, and Rhodes during the Cretan War led Philip V, King of Macedonia, to invade the Kingdom of Pergamon and pillage the countryside surrounding Adramyttium in 201 BC. As an ally of Rome, Pergamon fought in the Roman–Seleucid War against the Seleucid Empire. In 190 BC, Antiochus III plundered the countryside surrounding Adramyttium, but the appearance of a Roman–Pergamene fleet prevented him from taking the city. In the second century BC, "cistophori", the coinage of the Kingdom of Pergamon, were minted at Adramyttium. Attalus III, the last King of Pergamon, bestowed his kingdom to the Romans in his will, and thus, in 133 BC, Adramyttium came under Roman control. The city became part of the province of Asia.