Husyev made his senior international debut for Ukraine on 20 August 2003, replacing fellow debutant Serhiy Tkachenko at half time in a 0–2 friendly defeat to Romania at the Shakhtar Stadium in Donetsk. He scored his first goal for the team on 17 November 2004, opening a 3–0 away win over Turkey in the ninth minute, for 2006 World Cup qualification. Husyev played all five of Ukraine's games as they reached the quarter-finals at their first World Cup in Germany, scoring the winner in their last-16 penalty shootout against Switzerland. He also played all of their matches as they co-hosted UEFA Euro 2012 with Poland, in a group stage exit.