In Sevilla's UEFA Champions League campaign in 2017–18, Ben Yedder scored all three goals in a group stage victory over Slovenia's Maribor on 26 September, his first hat-trick in the competition. On 21 November, after scoring twice as Sevilla came from a 0–3 deficit at half time to draw with Liverpool, he taunted A.C. Milan – who lost the 2005 UEFA Champions League Final to Liverpool in a similar fashion – over Twitter. On 13 March 2018, in the second leg of the 2017–18 UEFA Champions League round of 16 against Manchester United at Old Trafford, Ben Yedder came on as a substitute in the 72nd minute and scored two goals in the span of 4 minutes to help secure a 2–1 win and enable Sevilla to reach the quarter-finals of the UEFA Champions League for the first time since 1958, and for the first time ever in the Champions League era.