Following the 2012 Northern Italy earthquakes, the hospital suffered numerous damages to its structures, especially the modern ones (while the 1908 buildings suffered few injuries), for a total of 27,348,000 euro, which led already on the morning of 20 May 2012 to evacuate all the patients, who were then transferred to other hospitals in the area, and to build a large temporary field hospital in the parking in front of it. The following 25 June, the "Concert for Emilia" was held to raise funds for the reconstruction of the Bernardino Ramazzini hospital in Carpi and the Santa Maria Bianca hospital in Mirandola. In the following months, the hospital departments were gradually reactivated, despite the limitations and cuts imposed by the 2011-2013 PAL.