On 19 September 1899, he was promoted to lieutenant-colonel and assumed command of the 7th Dragoon Guards. The regiment embarked the SS "Armenian" in Southampton on 8 February 1900, and departed for service in South Africa, with Lowe in command of the men on the ship. From 1900 to 1902, he led the regiment in the Second Boer War, being present at the capture of Pretoria and the Battle of Diamond Hill, and was promoted brevet colonel in November 1900. Lord Kitchener's despatch of 8 August 1901 related how "at midnight on the 30th July Colonel Lowe, 7th Dragoon Guards, successfully surprised a farmhouse, from which he took 11 armed prisoners with rifles, bandoliers and horses." Lowe was twice more Mentioned in Despatches: in Lord Roberts' Recommendations, 2 April 1901 and in