The end of the Pre-Columbian era arrived with Spanish conquest and occupation of the Zapotec peoples region in 1521. It was first renamed 'San Jacinto Leóntepec,' It then changed again to 'San Bartolomé Coyotepec,' by Bartolomé Sanchez, a soldier of Hernán Cortés awarded a local Encomienda. The first church was built in 1532. From its Spanish foundation was one of the larger settlements with three neighborhoods. This settlement was laid out by the same architect that designed the city of Oaxaca.