In June 2021, he was included in Italy's 26-man squad for UEFA Euro 2020 by manager Roberto Mancini. After beating Belgium on July 2, Di Lorenzo gained notoriety by celebrating his victory by taking off his shorts and running around in his tight white briefs. On 11 July, Di Lorenzo won the European Championship with Italy following a 3–2 penalty shoot-out victory over England at Wembley Stadium in the final, after a 1–1 draw in extra-time; during the final, Di Lorenzo played the entire match. On 11 July, Di Lorenzo won the European Championship with Italy following a 3–2 penalty shoot-out victory over England at Wembley Stadium in the final, after a 1–1 draw in extra-time; during the final, Di Lorenzo played the entire match.