In April 2019, he was named in England's squad for the 2019 Cricket World Cup. On 14 June 2019, in the match against the West Indies, Wood took his 50th wicket in ODIs. On 11 July 2019, in the semi-final against Australia, Wood played in his 50th ODI match for England. In the Cricket World Cup Final, Wood, batting at number 11, was run out off the last ball of the match which led to the game going to a Super Over. Wood also sustained a side injury during the game, which ruled him out of the first three Tests of the 2019 Ashes series.