On 30 January 1969, "Stribling" put to sea from Mayport, Florida, to make her second voyage to the Far East. Heading via the Panama Canal, San Diego, and Pearl Harbor, the destroyer made for Yokosuka, Japan, and then operations off the coast of Vietnam. "Stribling" participated in "Sea Dragon" and "Market Time" operations, and her duties also included bombardments on the gunline, search and rescue missions usually for downed carrier pilots, and Positive Identification Radar Advisory Zone (PIRAZ) duty. The latter assignment involved riding "shotgun" for larger PIRAZ ships armed with more sophisticated radar and target designation systems. That summer, "Stribling" plane-guarded for the carriers operating on "Yankee Station" in the Gulf of Tonkin. When not operating in the combat zone, she put into Kaohsiung, Taiwan; Hong Kong; and Subic Bay in the Philippines for repairs after a collision with a barge being towed by RVN tug during a nighttime underway replenishment . On 2 August 1969, "Stribling" cleared the combat zone to return home. On her way, she stopped at Kure and Yokosuka, Japan; Pearl Harbor; San Diego; Acapulco Mexico, and Panama. On 17 September 1969, she reentered Mayport.