On 29 June 1918, Safarov, as a member of the Presidium of the Ural Regional Soviet under Alexander Beloborodov, was a party to the unanimous decision to execute the Romanovs imprisoned in Yekaterinburg, who included the deposed Emperor Nicholas II, his wife Empress Alexandra, and their five children Olga, Tatiana, Maria, Anastasia, and Alexei. Safarov was a signatory to the resolution on the shooting, and sent a final telegram to Yakov Sverdlov in Moscow along with Filipp Goloshchekin seeking final approval. Yakov Yurovsky, the chief executioner, later recorded that a signed response from Sverdlov had been passed to him by Goloshchekin around 7:00 pm on 16 July. He later assisted in the procurement of materials for the disposal of the remains, and the confiscation of the Romanov's property by the state.