Drax campaigned for Brexit during the 2016 referendum. In April 2019, in a speech in the House of Commons, Drax said that he "made the wrong call" by supporting the government's Brexit deal and called for the resignation of Theresa May if she failed to take the UK out of the EU by 12 April. Drax praised May's successor, Boris Johnson, for achieving a trade deal in December 2020, but in February 2021 expressed concern over the Northern Ireland Protocol and disruption to trade in Northern Ireland.