Manuel Aurelio Cruz was born in Havana, Cuba on December 2, 1953 to Juan and Caridad Cruz. He fled to the United States with his parents in 1966 to escape the revolution, living in Florida before settling in Union City, New Jersey. In his youth, he spent eight years as a member of the emergency department staff at Saint James Hospital in Newark. He attended Seton Hall University, graduating with a Bachelor of Arts in Philosophy and a Master of Arts in Sacred Scripture. He studied for the priesthood at the Immaculate Conception Seminary School of Theology.