Lisicki entered the Mercury Insurance Open as the fifth seed but pulled out with an abdominal injury. She went straight back to London to prepare for the 2012 Summer Olympics. She entered singles where she was seeded 15, and in mixed doubles with Christopher Kas where they were unseeded. In the singles, she beat Ons Jabeur and Yaroslava Shvedova in the first and second round respectively. She lost to Maria Sharapova in the third round, after winning the first set and leading 4–2 in the second. In doubles, Lisicki and Kerber beat British pair Laura Robson and Heather Watson in the first round, after losing the first set whilst taking only eleven points and going 4–2 down in the second set. In the second round, they lost to Venus and Serena Williams. In mixed doubles, Lisicki and Kas beat second seeds Bob Bryan and Liezel Huber in the first round, and Daniele Bracciali and Roberta Vinci in the quarterfinals. In the semifinals, they lost to Andy Murray and Laura Robson. In the bronze medal match, they lost to third seeds Mike Bryan and Lisa Raymond.