Sir Francis Wyatt (1588–1644) was an English nobleman, knight, politician, and government official. He was the first English royal governor of Virginia. He sailed for America on 1 August 1621 on board the "George". He became governor shortly after his arrival in October, taking with him the first written constitution for an English colony. Also sailing with him on this voyage was his second cousin Henry Fleete Sr., who helped found colonies in both Virginia and Maryland. In 1622 he rallied the defense of Jamestown which was attacked by Native Americans, during which the lives of some 400 settlers were lost and he then oversaw the contraction of the colony from scattered outposts into a defensive core.