The settlement of Psachna was built by refugees after the sack of Chalcis in 1470 during the First Ottoman–Venetian War. During the Ottoman occupation, it was a small village with few houses. After Greek independence, refugees from Samos were installed in Psachna, leading to the naming of a district of Psachna as "Samiotika". The population of Psachna was increased in the last century when residents of the more mountainous villages such as Pyxaria, Vavoula, Apogremno moved in. In August 2020, the town and the region was badly hit from catastrophic floods that resulted in 6 deaths.