After the end of the Syrian campaign, "Jaguar" operated out of Alexandria, duties including escorting supply convoys to beseiged Tobruk, and shore bombardment duties off the coast of Libya. On 1 December 1941, her bridge was hit by a single 4.7 in shell accidentally fired by "Jervis" while the latter destroyer guns were being cleaned. Two men were killed, including "Jaguar"s commanding officer. Later that month, "Jaguar" was deployed to Malta for operations against Italian convoys carrying supplies to North Africa. On the night of 18/19 December, three cruisers and four destroyers of Force K set out from Malta to intercept an Italian convoy, but ran into a minefield north of Tripoli, with the cruiser striking four mines and sinking, the cruisers and also striking mines. The destroyer struck a mine when trying to rescue survivors from "Neptune", blowing her stern off. Early on 20 December, "Jaguar" found "Kandahar", but the seas were too heavy for "Jaguar" to take "Kandahar" under tow, so after picking up 165 survivors from the stricken destroyer's crew, "Jaguar" scuttled "Kandahar" with torpedoes.