Tzompantepec is a town and municipality located in the eastern portion of the Mexican state of Tlaxcala. It is located in the Central Mexican Plateau, almost entirely on the slopes of the La Malinche Volcano. The area was the earliest to be inhabited in Tlaxcala and it was also the site of the defeat of the Tlaxcallans in the early part of the Spanish Conquest. The municipality is mostly farmland but urban sprawl has limited both natural vegetation and wildlife.