In 1622, battles continued between neighboring tribes and English Settlers. This eventually became known as the Indian Massacre of 1622. Three years later in 1625, a smallpox and measles outbreak killed many Native Indians who did not have natural immunity to such illnesses. In 1650, European presence increased as more and more settlers arrived in North Carolina. With such large numbers of men arriving, the male to female ratio in the Albemarle region of North Carolina was close to 8 to 1. In 1670, marriages between British settlers and Indian women started to occur. This encouraged the exchange of cultures and prompted negotiations to end the constant battles.: During negotiations the battles continued and as a result the tribe's population dramatically decrease. By 1700, it is believed that the Weapemeoc tribe only had a population of around 200 people.