Tennant appeared on fashion catwalks for Shiatzy Chen, Bill Blass, Dior and Chanel. She was a muse of the designers Karl Lagerfeld, Gianni Versace, Alexander McQueen, Nicolas Ghesquière, Riccardo Tisci and Victoria Beckham. She also appeared in numerous other advertising campaigns, including Calvin Klein, Hermès, and in 2002 in an influential campaign for Burberry. In 2010, she starred in L.K.Bennett's Spring Summer campaign photographed by Tim Walker. During the Closing Ceremony of the 2012 London Olympics, Tennant along with Naomi Campbell and Kate Moss was one of the British models wearing fashions created by British designers specifically for the event.