Muirhead won the silver medal as the Scottish team skip at the 2010 Ford World Women's Curling Championship after losing 8–6 to Germany in the final, which went to an extra end. The team finished the round robin matches in third place with an 8–3 record, then advanced to the final by winning the 3 vs. 4-page playoff against Sweden, and the semi-final against Canada, both games in 8 ends and on the same day. Her teammates were third Kelly Wood, second Lorna Vevers, lead Anne Laird and alternate Sarah Reid. Muirhead's rink did not win the Scottish championship in 2011, but she was invited to play as Scotland's alternate at the 2011 Capital One World Women's Curling Championship, where the team finished 9th. The team did win the Scottish championship in 2012, and would finish 6th at the 2012 Ford World Women's Curling Championship. She won the Scottish championship for a fourth time in 2013. The team would go on to play at the 2013 World Women's Curling Championship, where they defeated Sweden's Margaretha Sigfridsson in the final. The win made Muirhead the youngest skip to ever win the World Women's Curling Championship.