Trainor and Legend sang "Like I'm Gonna Lose You" on "The Tonight Show Starring Jimmy Fallon" on May 21, 2015. She performed the track solo in a set for "The Today Show" on May 22, 2015, along with "Dear Future Husband", "All About That Bass" and "Lips Are Movin". An a cappella rendition of the song by Trainor and Legend premiered on May 27, 2015, by "Entertainment Weekly", as part of Pop TV's "Massive Musical Mash-Up". Trainor also performed the song alone on "Jimmy Kimmel Live!" in July 2015, and then along with Legend on "The Ellen DeGeneres Show" on October 14, 2015. Trainor performed the song on the American Music Awards of 2015 on November 22, 2015, in a medley with Charlie Puth's collaboration "Marvin Gaye". Girl group Fifth Harmony, with whom Trainor previously collaborated on their debut album "Reflection", covered the song at the 2016 Billboard Women in Music ceremony, at which Trainor was supposed to perform but was unable to due to her vocal cords being damaged. The song was part of the setlist for Trainor's The Untouchable Tour (2016), where Trainor was joined by James Corden during a performance.