At the Copa América Centenario in 2016, Higuaín was named to Gerardo Martino's 23-man Argentina squad, and was selected as his team's starting centre forward. On 18 June, he scored twice in the team's 4–1 quarter-final defeat of Venezuela. Three days later, he once again scored two goals as Argentina defeated the hosts United States 4–0 in the semi-final. He played in the final against Chile eight days later, a repeat of the previous year's final, as the "Albiceleste" once again lost in a penalty shootout following a 0–0 draw after extra time. Following the match, Higuaín once again came under criticism in the media for squandering a one on one opportunity for the third consecutive final with Argentina.