During his time in office, Gröhe also focused heavily on global health issues. Alongside his colleague Gerd Müller, he travelled to Ghana and Liberia right after the West African Ebola virus epidemic in 2015. That same year, he accompanied Merkel when she spoke at the opening of the annual World Health Assembly in Geneva on the need for reforming the World Health Organization (WHO) to ensure there is prompt response to health emergencies. As part of Germany's G7 presidency in 2015, he brought together G7 Health Ministers to adopt a declaration addressing antimicrobial resistance (AMR).