On 23 October 2018, Alex Sandro made his 50th UEFA Champions League appearance (excluding qualifying rounds) in a 1–0 away win over Manchester United. He made his 100th Serie A appearance with Juventus on 30 March 2019, in a 1–0 home win over Empoli. In Juventus's following league match on 2 April, a 2–0 away win over Cagliari, he made his 150th appearance for the club. On 20 April, he scored the temporary equaliser as Juventus came from behind to defeat rivals Fiorentina 2–1 at home and win the Serie A title.