The combat unit was soon reformed and placed under the command of Lieutenant-Colonel Pedro Conde. On 19 January 1817, the companies of the regiment formed the vanguard of the patriot forces of General Soler. They crossed the Andes through the Paso de Los Patos, taking part in the Battles of Achupayas, Putaendo, Las Coimas and Guardia Vieja. El 12 February 1817, the formation played an important role in the victory obtained during the Battle of Chacabuco against Spanish backed forces. The combat companies were then placed under the command of General Bernardo O' Higgins, taking part in the liberation of southern Chile, fighting at the Battles of Gavilán, Carampague and Talcahuano. Durante the Second Battle of Cancha Rayada, the regiment held firm despite a surprise enemy counterattack.