Anne married secondly in about 1474 to Thomas St. Leger (c. 1440 – 1483), a loyal follower of his brother-in-law King Edward IV (1461–1483). He took part in the Duke of Buckingham's attempted rebellion against King Edward's younger brother and eventual successor King Richard III (1483–1485), on the failure of which he was executed in 1483. King Edward IV had however in 1467 extended the remainder of most of the former Duke of Exeter's lands to the King's sister, Anne, and to any heirs of her body. Thus, if she remarried any future children could inherit them.