Wise was traded along with Bernie Carbo from the Cardinals to the Red Sox for Reggie Smith and Ken Tatum on October 26, 1973. In 1975, he won 19 for the Red Sox, winners of the AL East. Wise had another no-hitter broken up against the Milwaukee Brewers on July 2. In the first game of a doubleheader, former Red Sox George Scott homered off Wise with two out in the ninth to break up the no-hitter. Wise would have joined Cy Young and Jim Bunning as pitchers who had hurled no-hitters in both leagues (Nolan Ryan, Hideo Nomo and Randy Johnson have done it since). Wise went on to win his only start in the 1975 ALCS against Oakland, and was the relief pitcher of record in Game 6 when Carlton Fisk ended the 12-inning game with his oft-replayed walk-off home run.