Since making her debut for the Germany women's national football team in August 1996, Angerer won a total of 146 caps. She understudied Silke Rottenberg at the UEFA Women's Championship in 1997, 2001 and 2005; the FIFA Women's World Cup in 1999 and 2003; as well as the 2000 and 2004 Olympic football tournaments. When Rottenberg was injured before the 2007 FIFA Women's World Cup, Angerer took over as first choice and kept a clean sheet in every round as Germany won the tournament. She remained first choice for the 2009 and 2013 editions of the UEFA Women's Championship, the 2011 and 2015 FIFA Women's World Cups and the 2008 Olympics.