Born on 12 January 1764, Sir Harford Jones-Brydges was the son of Harford Jones of Presteign, Radnorshire by Winifred, daughter of Richard Hooper of the Whittern, Herefordshire. Early in life he entered the service of the East India Company, and, acquiring great proficiency in the oriental languages, he was appointed the Company's first Resident and Consul in Baghdad. In 1798, fearing that Napoleon's expedition to Egypt might present a threat to British interests in India, the Company's Directors accepted a suggestion to establish a Residency in Baghdad. The Residency in Baghdad was intended to provide direct access to the Ottoman Vali (provincial governor) there, rather than through an agent of the Company Resident in Basra. Harford Jones had been the Company's Assistant Resident in Basra since 1784, and seems to have lobbied for establishing the post in Baghdad. However, various circumstances rendered him largely ineffective, except in arranging for the Company's overland mail to use a more secure and less expensive route through Baghdad instead of across the desert from Aleppo. He finally left Baghdad in 1806.