He made his international debut against Canada on May 30, 2000, and received his final cap against Nicaragua on February 15, 2007. The high point of Izaguirre's international career came in the consolation match of the 2001 Copa América against Uruguay, when he scored in regulation time and hit the decisive penalty in the shootout to secure third-place honors for Honduras. He has represented his country in 2 FIFA World Cup qualification matches and played at the 2001 and 2007 UNCAF Nations Cups as well as at the 2005 CONCACAF Gold Cup.