Senderos began his career at Servette, before moving to England as a teenager with Arsenal. He made 116 appearances over seven seasons with the North London club, and won the FA Cup in 2005. Following loans to Milan and Everton, he then moved to Fulham on a free transfer in 2010, where he played for four seasons. Senderos then had brief spells at clubs in Spain, England, Scotland, Switzerland and the United States.