The Jewish population in 1900 was 5,080. During World War II, Pruzhany was occupied by the Germans from 26 June 1941 to 17 July 1944. In 1941, the Nazis herded the Jews of Białystok and the vicinity here to create a ghetto. In "Aktion" roundups on 28-31 January 1943, the Nazis deported 10,000 Jews of the Pruzhany ghetto to Auschwitz, via Birkenau, where the men, women and children were murdered.