At the 2021 Azerbaijan Grand Prix, Pérez qualified in 7th place, starting in 6th place due to a grid penalty for Lando Norris. In the race he made a strong start, moving up to 3rd place by lap 8. In the pit stop window, he then passed Lewis Hamilton to take 2nd place. Having stayed in this position for most of the race, Pérez moved into the lead following a tyre failure for teammate Max Verstappen on lap 47. With the race restarting on lap 50, he remained in the lead for the final 2 laps to take the second win of his career and his first for Red Bull.