Muslera began the 2008–09 season as second-choice goalkeeper behind new signing Juan Pablo Carrizo, but regained the starting spot in January 2009 following a run of poor form by Carrizo, coupled with conflicts with team management. Muslera's first starting appearance in the Serie A season saw him make several saves in a 3–1 loss to Sampdoria, including saving an Antonio Cassano penalty. Further impressive performances in away wins over Napoli and Genoa, as well as in his first ever "Derby della Capitale" against Roma, saw Muslera regain a considerable amount of faith he had lost the previous season.