On the April 20 episode of "Raw," Mysterio defeated Murphy to qualify for the Money in the Bank ladder match. At Money in the Bank, Mysterio failed to win the match. On the May 11 episode of "Raw", Mysterio and Aleister Black were booked to face Seth Rollins and Murphy in a tag team match, where they won by disqualification when Rollins pulled Mysterio off of the ring apron and used the corner of the steel steps to pierce Mysterio's eye, taking Mysterio out of action. This resulted in speculation that Mysterio would "retire", following weeks of being mocked by Rollins. However, Mysterio and Dominik later began targeting Rollins, with Mysterio challenging Rollins to an Eye for an Eye match at The Horror Show at Extreme Rules, and the match was won by "removing" an opponent's eyeball. At Extreme Rules, Mysterio lost the match in a gruesome manner, but doctors believed his eye was able to be saved. At Payback, Mysterio and his son, Dominik Mysterio would go on to defeat Rollins and Murphy in a tag team match. As part of the 2020 Draft in October, Mysterio was drafted to the SmackDown brand. Mysterio and Dominik would continue feuding with Rollins and Murphy. Mysterio and Rollins would eventually face each other in a No Holds Barred Final Chapter match on the November 13 episode of SmackDown, where Mysterio would pick up the win after assistance from Murphy, who turned on Rollins. At Survivor Series, Rey and Dominik would both compete in a dual brand battle royal, but both men were eliminated. On January 31, 2021, at Royal Rumble, Mysterio would enter the Royal Rumble match at number 26, but would be eliminated by Omos.