At international level, Agüero represented the Argentina under-20 team as they won the 2005 and 2007 FIFA U-20 World Cups. He played at the 2008 Olympics, scoring two goals in the semi-final against Brazil as Argentina won gold. Agüero is his country's third-highest all-time top goalscorer and has earned over 100 caps, representing the senior team at three FIFA World Cups (in 2010, 2014 and 2018) and five Copas América (in 2011, 2015, 2016, 2019 and 2021), winning the Copa América in 2021.