All of the E class were assigned to the 5th Destroyer Flotilla (DF) of the Home Fleet upon commissioning during 1934. Following the Italian invasion of Abyssinia, the entire flotilla was sent to the Red Sea in August 1935 to monitor Italian warship movements until April 1936. Refitted upon their return, many were deployed to Spanish waters during the Spanish Civil War in 1936–39 to intercept shipping carrying contraband goods to Spain and to protect British-flagged ships. While the F-class ships were assigned to the 6th Destroyer Flotilla of the Home Fleet, they followed much the same pattern as their E-class sisters. In April 1939 the 5th and 6th DFs were renumbered the 7th and 8th Destroyer Flotillas, respectively. In mid-1939, newly commissioned J-class destroyers began to replace the E-class ships and they were reduced to reserve for lack of manpower. Increasing tensions with Nazi Germany in August, caused the British to mobilize the Navy's reserves, which allowed the ships to be manned again and assigned to the 12th Destroyer Flotilla of the Home Fleet.