When the Spanish arrived in the 16th century, the region was dominated by the Totonacs, who were then in turn dominated by the Aztec Empire. Because of this, the Totonacs allied with the Spanish against the Aztecs to conquer Tenochtitlán . However, war, disease and forced labor brought the Totonac population down drastically. The Totonac population in Cempoala is estimated to have been about 80,000 when the Spanish arrived in 1519 but with only eighty left in 1550. The Spanish also took their lands for cattle raising until the ethnicity occupied only about half of what it used to. In many areas, the Totonac population was replaced by Spanish, mestizo and African peoples. Until the 17th century, the Spanish mostly respected Totonac leadership as their help against the Aztec made them non-threatening militarily. Evangelization was likewise slow, with only sixteen parishes in all of Totonacapan by 1750.