James Pattison Walker (17 March 1823 – 14 February 1906, Clacton-on-Sea) was a British surgeon who served as Surgeon-General in the Indian Medical Service. He was present at the fort of Agra during the 1857 rebellion and was appointed the first Superintendent of the Penal Settlement in the Andamans, which had been created to accommodate prisoners from the 1857 uprising.