From September 1983 to December 1989, Njie-Saidy was Deputy Executive Secretary of the Women's Bureau, the executive decision-making body of the National Women's Council. Two years after the 1994 Gambian coup d'état in which Yahya Jammeh seized power, in July 1996 Njie-Saidy was appointed as Minister of Health, Social Welfare and Women's Affairs. On 20 March 1997, a few months after the 1996 presidential election in which Jammeh was victorious, Njie-Saidy was appointed as Vice-President of the Gambia and Secretary of State for Health, Social Welfare and Women's Affairs.