Hernández made his competitive debut on 8 August and scored his first goal in the process, netting United's second of a 3–1 victory over Chelsea in the 2010 FA Community Shield. He came on at the start of the second half and got on the end of a pass from Antonio Valencia before the Mexican's shot deflected off his own face and into the net. On 16 August, Hernández made his Premier League debut as he replaced Wayne Rooney in the 63rd minute of their 3–0 home victory over Newcastle United. He scored his first Champions League goal on 29 September, coming off the bench to score the only goal in an away win over Valencia. He scored his first league goal for United in a 2–2 home draw against West Bromwich Albion on 16 October. Eight days later he scored his first brace for the club, also his first away league goals, in a 2–1 away win over Stoke City. Two days on from this display, he came off the bench to score a last-minute winner, his first ever League Cup goal, in a 3–2 win over Wolves which sent them through to the quarter-finals where they were then knocked out by West Ham United. On 1 January 2011, he came off the bench to head the winning goal in a 2–1 away win over West Bromwich Albion. Hernández became the top scoring Mexican in Premier League history after opening the scoring in a 2–1 home victory over Stoke City on 4 January.