On 28 April the tanker departed California for Dutch Harbor, Alaska. Arriving on 5 May, she sailed again the next day for Adak whence she operated throughout the Aleutian Islands Campaign. After that campaign "Neosho" returned to the South Pacific, departing Pearl Harbor on 10 November with Task Force 50, to refuel and replenish Task Groups 50.2 and 50.3 prior to the Gilbert and Marshall Islands campaign. After the bloody, but successful, landings there she joined TU 16.10.11 to fuel TF 53 as it steamed toward the next objective, the Marshall Islands.