In the run-up of the 2016 constitutional referendum the UdC campaigned for the "No", while the NCD was among the keenest supporters of the "Yes". After the referendum, which saw a huge defeat of the "Yes" side, the UdC left Popular Area altogether. However, some UdC splinters, notably including Pier Ferdinando Casini, Gianpiero D'Alia and Gian Luca Galletti, launched an alternative party named Centrists for Europe (CpE) and confirmed their alliance with the NCD within Popular Area.