At the snap general election of 2017, Main received 43% of the vote, Daisy Cooper (Liberal Democrat) received 32%, Kerry Pollard (Labour) received 23% and Jack Easton (Green Party) received 2%. UKIP declined to stand a candidate in recognition of Main's eurosceptic views. She became Chair of the All-Party Parliamentary Group (APPG) on Bangladesh, and served on a number of Select Committees; in addition she became a member of the Panel of Chairs. At the 2016 EU Referendum, Main campaigned for a "Leave" vote.