In November, Itō, along with one regiment of the 38th Division, was shipped to Guadalcanal. On 11 November, during the pivotal Battle of Guadalcanal, Itō was positioned by Lieutenant-General Harukichi Hyakutake to attack Marines under the command of United States General Alexander Archer Vandegrift who were involved in the Matanikau offensive against Japanese positions. However, Vandegrift called off his offensive that day after receiving intelligence reports of Hyakutake's plans. Itō later helped command 38th Division troops during the Battle of Mount Austen, the Galloping Horse, and the Sea Horse. He and the 38th's survivors on Guadalcanal were evacuated by the Japanese navy during the first week of February 1943. Itō became commander of the 40th Independent Mixed Brigade, stationed at New Ireland on 8 July 1944. He was promoted to lieutenant-general on November 26 of that year.