Pietrangelo has competed with Team Canada at the junior and senior level, winning a gold medal win with Canada's under-20 team at the 2009 World Junior Championships. Individually, he was named Best Defenceman at the 2010 World Junior Championship and 2011 Men's World Championship. Pietrangelo was named to the 2014 Canadian Olympic hockey team and won a gold medal at the 2014 Winter Olympics.