During the second game of the 2006-07 Guinness Premiership season against Worcester Warriors on Friday, 8 September, Wilkinson was helped from the pitch after 47 minutes with a knee injury incurred when one of his team members fell on him after he was tackled. A scan confirmed that he had torn the medial ligament of his right knee. He returned to play a full 80 minutes in the 26–21 win against leaders Bristol on Friday, 3 November, kicking a conversion, a drop-goal and two penalties. It was reported on 9 November that Wilkinson suffered a lacerated kidney during the match. He returned from this injury in the Premiership game against Leicester Tigers on 27 January 2007, coming off the bench after 37 minutes. On 29 January 2007, Wilkinson was selected at fly-half in the starting line up for England in their 2007 Six Nations Championship opener against Scotland. England comprehensively beat Scotland 42–20 to regain the Calcutta Cup, Wilkinson making an impressive return, scoring 27 points with five penalties, two conversions, a drop goal, and a try. This broke the previous Calcutta Cup individual record of 24, set by Rob Andrew. Wilkinson was awarded the RBS Man of the Match as adjudicated by BBC commentator, Brian Moore.