In May 2019, Zambrano was named in Peru's final 23-man squad for the 2019 Copa América by manager Ricardo Gareca, earning his first call–up in three years. He made his first national appearance in three years, starting the whole game, in a 0–0 draw against Venezuela on 15 June 2019. Despite suffering from an injury, Zambrano became the national side first choice centre–back position and helped Peru reached the final of the Copa América. He appeared in the 2019 Copa América Final against hosts Brazil on 7 July, at the Maracanã Stadium; the match eventually ended in a 3–1 victory to Brazil.