In Game three of the 2010 NLDS against the Atlanta Braves, Sánchez struck out eleven batters in a game the Giants won 3–2. Sánchez gave up three runs over six innings in Game two of the 2010 NLCS, but he was the losing pitcher in a 6–1 loss. Sánchez also started Game six. He only lasted two innings, giving up two runs and getting pulled from the game after an argument with Chase Utley. However, the Giants won the game 3–2 and returned to the World Series. Sánchez's only World Series game was unsuccessful, as he gave up all four runs in 4.2 innings in the Giants' 4–2 loss to the Texas Rangers in Game three. However, the Giants ultimately won the World Series for the first time in fifty-six years.