During the Soviet period, Manglisi continued to function as a spa and its sanatoriums provided services for people with respiratory diseases. In 1924, the state-run airline Zakavia organized a short-lived line Tiflis—Manglis to serve local tourist interests. On August 29, 1924, the Red Army barracks in Manglisi were raided, ultimately unsuccessfully, by anti-Soviet insurgents led by Kakutsa Cholokashvili.