Between 2005 and 2006 Deborah recorded her fourth album, called "Destination Moon", arranged and produced by Rob Mounsey. A tribute album to jazz singer Dinah Washington, Cox noted it a concept album that she had in mind for years. Most of the album was recorded live with a forty-piece orchestra with Rob Mounsey arranging. Eventually released by Decca Records in June 2017, "Destination Moon" peaked at number three on the "Billboard" Top Jazz Albums. The same year, Cox co-starred alongside Golden Brooks and Darius McCrary in Leslie Small's film "A Good Man is Hard to Find". Based on the musical stage play of the same name, the comedy depicts the story of three women who each undergo romantic crises that challenge their personal and spiritual relationships. In 2008, Cox performed the Canadian national anthem at the NBA All-Star Game in New Orleans, receiving rave reviews. She also contributed the song "This Gift" to the soundtrack of the 2008 romantic drama film "Meet the Browns", directed by Tyler Perry, and served as a supporting act on Cyndi Lauper's True Colors Tour 2008.