In the British black comedy "Burke and Hare" (2010), loosely based on the Burke and Hare murders, Fisher starred opposite Simon Pegg and Andy Serkis as a young former prostitute and the love interest of one of the titular characters. The film found a limited audience in theatres, and "Variety" wrote that "Pegg and Fisher, just about holding up their end of the bargain by delivering the film's portion of sweet romance, are hardly given anything funny to say", as part of an overall mixed reception. Fisher voiced a hot-tempered but good-hearted desert iguana befriending an eccentric chameleon in the 3D animated Western action comedy "Rango" (2011), featuring Johnny Depp, Abigail Breslin and Bill Nighy. The film received positive reviews and made US$245.7 million worldwide. For her role, Fisher won the Alliance of Women Film Journalists Award for Best Animated Female.