Plazzi was part of the Luna Rossa Challenge team that won the 2000 Louis Vuitton Cup, the Challenger Selection Series which took place in Auckland in advance of the 2000 America's Cup. Matteo Plazzi remained stayed with Luna Rossa Challenge for the 2003 and 2007 Louis Vuitton Cup America's Cup campaigns before joining Oracle Racing and as navigator on "USA 17" when it won the 2010 America's Cup. Plazzi returned to Luna Rossa Challenge for the 2013 America's Cup.