At the World Championships, Tuktamysheva cleanly performed her short program to place third in the segment, behind Anna Shcherbakova and Rika Kihira. In the free skate, Tuktamysheva landed both of her triple Axel attempts cleanly, but fell on a triple flip later in the program. Despite the mistake and placing only third in the free program, she was able to claim second place overall due to mistakes from Kihira, and Alexandra Trusova coming back from a major deficit after the short program. She took the silver medal in between countrywomen Shcherbakova with the gold, and Trusova with the bronze. This was the second time, after the United States in 1991, that a single country swept the ladies' podium at the World Championships. Tuktamysheva's placement, combined with Shcherbakova's, qualified three berths for Russian ladies at the 2022 Winter Olympic Games in Beijing.