In 1516 Lautrec received the government of the Milanese duchy, but by his severity made the French domination insupportable. In 1521 he succeeded in defending the duchy against the Spanish army, but in 1522 he was completely defeated at the Battle of Bicocca, and was forced to evacuate the Milanese. The mutiny of his Swiss troops had compelled him, against his wish, to engage in the battle.