In the First Anglo-Dutch War "Brederode" was present under Tromp's command at the Battle of Dover on 29 May 1652. After Tromp's failure to bring the English to battle off the Shetland Islands in July, Tromp was relieved and Michiel de Ruyter took over command. When De Ruyter was subordinated to De With in September, "Brederode"s crew refused to let the latter come on board to take command, so he had to content himself with "Prins Willem". Without Tromp, "Brederode" fought at the Battle of the Kentish Knock on 8 October 1652.