With their performance in the 2016 LCS season, Cloud9 qualified as the second seed in the North American Regional Qualifiers tournament for the 2016 World Championship. At the Regional Qualifiers, they swept Team EnVyUs, 3–0, in the second round and defeated Immortals, 3–1, in the finals, giving them the third seed for North America in the 2016 World Championship. At the 2016 World Championship, Cloud9 was placed in a group with IMay, SK Telecom T1, and Flash Wolves. Cloud9 went 3–3 in the group and earned the a spot a spot in quarterfinals, where they faced Samsung Galaxy on October 14. The team was swept by Samsung, 0–3, and were eliminated from the playoffs.