The Uruguayan's impressive season saw him cement his position as the Roman club's first choice in the 2009–10 season, despite the arrival of Argentine goalkeeper Albano Bizzarri on a free transfer. Muslera played in goal as Lazio opened the season with a 2–1 win over 2008–09 Serie A champions Internazionale in the 2009 Supercoppa Italiana, played in Beijing.