Following two successive disappointments, newly appointed manager Marcello Lippi kept Nesta in the starting lineup as Italy topped their qualification group en route to the 2006 World Cup. Despite starting the final tournament strongly, helping Italy to keep a clean sheet in their opening win over Ghana, the World Cup turned out to be a personal disappointment for Nesta, as an injury in the final group game against the Czech Republic, which Italy won 2–0, put him on the sidelines while Italy went on to win the trophy. After the World Cup, Nesta made one appearance in the Euro 2008 qualifiers, in a 3–1 away win against Georgia on 11 October 2006, but continuous injuries forced him to retire from the international team. Prior to the final tournament, Nesta declined Roberto Donadoni's invitation to return to the national team. Two years later, he similarly turned down an invitation from Marcello Lippi prior to the 2010 World Cup. In total he made 78 appearances for Italy.