Nastasić signed a five-year contract with Manchester City, ending on 30 June 2017. He was part of an exchange deal with Stefan Savić. He made his debut for the club on 18 September 2012, starting in a Champions League away fixture against Real Madrid at the Santiago Bernabéu Stadium. He made his Premier League debut on 29 September in a 2–1 win against Fulham. He cemented his place in the starting XI and his great form won him the club's Player of the Month Award for November. Quickly becoming a fan favourite, the youngster pushed 30-year-old Joleon Lescott out of the starting lineup in centre-back position and was selected to start in the 2013 FA Cup Final, a 1–0 defeat by Wigan Athletic. In May 2013, he was named Manchester City's Young Player of the Season.