The program primarily features interviews with reporters covering the major stories of the evening, panels composed of former government officials and subject matter experts, and the occasional politician. Williams eschews the conflict-ridden panels of competing opinion shows. Interviews with newsmakers are either live or to tape as close to air time as possible, to maintain immediacy. Similar to the original "Nightline" which focused on the Iran hostage crisis, the program focused primarily on the actions of the presidency of Donald Trump and Williams leads each broadcast noting the number of days since the Trump presidency began, as well as how many days remain before it ends. Since the presidency of Joe Biden began, the program now counts the number of days of the Biden administration and mostly discusses Biden administration actions.