Kluber was named a member of the 2016 American League All-Star team on July 7, 2016, his first selection, as a replacement for an injured Marco Estrada. Kluber was the winning pitcher in the All-Star Game. He finished the 2016 regular season with an 18–9 record, 3.14 ERA, an AL-leading 149 ERA+, and 227 strikeouts in 215 innings.