Sailing from the West Coast for the western Pacific on 28 September 1965, she provided gunfire support off Vietnam, operated as a plane guard in the South China Sea, and fired on targets in the Mekong Delta, before returning to Long Beach on 8 April. Getting underway again for the western Pacific on 28 March 1967, she patrolled off North Vietnam, as part of Operation Sea Dragon, and protected aircraft carriers in the Tonkin Gulf, before arriving at Long Beach on 20 September. Underway from Long Beach to the western Pacific on 18 July 1968, she again conducted several shore bombardments and guarded carriers in the Tonkin Gulf before returning to Long Beach on 26 February 1969.