The son of Luis de la Cruz and of Josefa Prieto Sotomayor, and was a cousin of future presidents José Joaquín Prieto and Manuel Bulnes. He joined the Army on October 27, 1811, and participated actively in the battles of Chacabuco, Maipu and Pangal during the Chilean War of Independence. He married Josefa Zañartu Trujillo, and had a single daughter: Delfina de la Cruz Zañartu who in turn was the wife of future president Aníbal Pinto.