Patrick remained with Stewart-Haas Racing for the duration of the renamed Monster Energy NASCAR Cup Series in 2017. She began her campaign with her best finish in any NASCAR Cup Series race with a fourth place at the Advance Auto Parts Clash exhibition race at Daytona. Patrick was credited with a 33rd-place finish for the season-opening Daytona 500 after she was forced into retirement from being caught up in a multi-car accident. She later took her first top-ten finish in seventy-seven races when she placed tenth at Dover on June 4. On November 17, Patrick announced that she would step away from full-time racing after the season finale at Homestead-Miami, though she also announced plans to compete in the 2018 Daytona 500 and 2018 Indianapolis 500. She retired halfway through when her right-rear tire blew after glancing the wall and she collided heavily with another barrier. Patrick finished the 2017 season with one top-ten, eleven DNFs and an average finish of 23.8. She scored 511 points, putting her twenty-eighth in the drivers' standings.