Between 1849 and 1867 Spence contributed to the exhibition of the Royal Academy five times: in 1850 with "Ophelia", in 1856 "Venus and Cupid", in 1861 "Hippolytus", and in 1867 "The Parting of Hector and Andromache". He contributed "Highland Mary" to the Exposition Universelle 1855, and two works, "Finding of Moses" and "Jeanie Deans before Queen Caroline", to the International Exhibition 1862. A number works of his that were not exhibited in England were engraved for the "Art Journal".