After his F3000 championship victory in 1990, Comas was selected to drive for the Ligier F1 team in 1991. The Ligier JS35 with its Lamborghini engine proved uncompetitive throughout the season. Comas failed to qualify for the race on his first attempt in Brazil, achieved his first finish with 10th at Imola, and achieved his highest finish of the season with 8th in Canada, scoring no points during the season. Although he failed to qualify on two other occasions and suffered a spectacular crash at Hockenheim, he generally compared well with more experienced teammate Thierry Boutsen who also failed to score any points. Early in 1992, Comas's place in the team was briefly threatened by Alain Prost who tested the team's new Renault-powered car with a view to driving for, and possibly buying the team. Ultimately Prost chose not to proceed, and Comas retained his drive alongside Boutsen for the season. The 1992 car, the Ligier JS37 seemed promising, a brand new design featuring the race-winning Renault V10 engine, but it proved to be only inconsistently competitive. Comas scored his first career F1 point with 6th place in Canada, scored 5th at Ligier's home race in France and a further point in Germany during a mid-season revival of the team's fortunes. With four points, he was generally faster than and outscored Boutsen, and finished 11th in the Driver's Championship. At the 1992 Belgian Grand Prix Comas was involved in a severe accident at the Blanchimont corner during Saturday qualifying. Left unconscious in his car beached in the middle of the track with the engine still running, Comas was rescued by Ayrton Senna who stopped his own car, ran to help Comas, and held the Frenchman's head in a stable position until medical assistance arrived. Comas credited Senna with saving his life.