In 2019, he was the presidential candidate for the "Alianza Bolivia Dice No" as a member of the Democrat Social Movement for the 2019 general elections. Ortiz obtained fourth place with 4.24% of the popular vote, though the results were annulled as a consequence of the ensuing political crisis. The crisis resulted in the resignation of Morales and the assumption to the presidency of opposition Jeanine Áñez, a member of Ortiz's party.