In late November 1945, Conzelman was hired for a second time to serve as head coach of the Chicago Cardinals starting with the 1946 NFL season. During the 1947 Chicago Cardinals season, the Cardinals with their "Million Dollar Backfield" compiled a 9–3 record and defeated the Philadelphia Eagles in the 1947 NFL Championship Game. Conzelman's 1948 Cardinals team compiled an 11–1 record during the regular season, led the NFL in offense with an average of 32.9 points per game, and lost to the Eagles in the 1948 NFL Championship Game. In their second stint under Conzelman, the Cardinals compiled a 26–9 record from 1946 to 1948.