On June 8, the 75th Pennsylvania participated in the Battle of Cross Keys near Harrisonburg, Virginia. The regiment arrived in an open area to the left of the Cross Keys Road, just past Pirkey's farm, at a little after 2:00 p.m. The men formed into double columns, but were held in reserve. The 75th Pennsylvania advanced to relieve other units on the left flank, sustaining heavy losses. However, as the regiment started to deploy, it was ordered to retreat into a gully to give the artillery a clear lane of fire. Thereafter, the regiment executed an orderly withdrawal. The next morning, federal troops found that the Confederates had abandoned their positions during the night. The Battle of Cross Keys was considered a Confederate victory.