Although the South Korea (LCK) representative, Kingzone DragonX, lost to China's (LPL) representative Royal Never Give Up (LPL) in 2018 Mid-Season Invitational (MSI) Finals, all three teams from South Korea (LCK) started in the Main Group Stage, having won the 2017 Mid-Season Invitational and the previous two World Championships. With the results of 2018 MSI and following their separation from the rest of the Southeast Asian (SEA) region, Vietnam (VCS) had a direct seed into the Main Group Stage for the summer split victor in their region, but unlike the previous year, Vietnam had no additional slots in the Play-In Stage for their summer runner-up team, because of the 24 team limit. The North American (NA LCS) summer split champion team was seeded to Pool 2 due to their performance at the 2018 Mid-Season Invitational.