In the year 1736, Kalhoro was officially entitled as the "Kalhora Nawab of Sindh" and was given the title "Nawab Khuda-Yar Khan" by the Mughal Emperor Muhammad Shah. In 1739, during the invasion of the Mughal Empire by Nader Shah, Mian fled to Umerkot for shelter but was captured by the King of Iran. Mian Noor Mohammad Kalhoro sent a small force to assassinate Nader Shah and turn events in favor of the Mughal Emperor during the notorious Battle of Karnal in 1739, but this plot failed.