Quixall joined Manchester United in September 1958 for a then British record fee of £45,000, one of Matt Busby's key recruits in building a new team in the aftermath of the Munich air disaster, which had killed eight players and ended the careers of two others on 6 February that year. After seven games without a win for United, Quixall eventually helped the team go on a run of only two losses in 23 matches to end the season as runners-up in the First Division. Quixall's only medal with the club was the 1963 FA Cup. Altogether, he scored 56 goals in 184 games for the Red Devils. Manchester United midfielder Bobby Charlton recalled in his autobiography that Quixall played a key role in many of his goals in this era. He noted that Quixall "played a significant role in my rush of goals. When I broke through an offside trap, often it was to get on to the end of one of Albert's perfectly placed passes".