Khoury was born in Trieste, Italy in 1976 from a Lebanese father and a Syrian mother from Assyrian ancestry. Khoury grew up in an era defined by Lebanon’s civil war. In 1997 Khoury graduated from the Lebanese American University (LAU), with a B.A. degree in Communication Arts. After working as an actress and assistant director in few television shows and plays as well as hosting two radio shows, Khoury moved to the United States, where she pursued her graduate studies and earned her M.F.A in Theatre Directing from the University of Arkansas (UOA) in 2002.