In 2007 Neffa composed the musical score of Ferzan Özpetek's "Saturn in Opposition", for which he won a Globo d'oro for best score and a Nastro d'Argento and a Ciak d'oro for best original song ("Passione"). In 2010 he started the musical project Due di Picche with the rapper J-Ax. In 2016 he returned to compete at the 66th edition of the Sanremo Music Festival with the song "Sogni e nostalgia".