At the 2010 PDC World Championship, Whitlock made a great impression, beating Colin Osborne (3–1), Wayne Jones (4–0) and Terry Jenkins (4–2), before going on to beat James Wade 5–3 in an epic encounter, setting up a semi final clash against Raymond van Barneveld which he won 6–5, after falling 4-2 behind. In the final against Phil Taylor, he lost the first set before winning the next two, including his second 170 checkout of the tournament, but Taylor would also make his second 170 checkout later in the match and went on to win 7–3.