His grandson Louis II (1460-1525), commanded French troops in the conquest of Lombardy for Louis XII. Defeated and wounded fighting the Swiss at Novarra in 1513, he redeemed his reputation by raising the siege of Marseilles against the Constable de Bourbon's Imperial troops in 1523 before being killed at the Battle of Pavia in 1524. In 1485 he had wed the "princesse du sang" Gabrielle de Bourbon, daughter of Louis I, comte de Montpensier, subsequently marrying the daughter of Cesare Borgia. He inherited from his mother Marguerite d'Amboise, vicomtesse de Thouars, the title, "prince de Talmond", which Du Cange noted, in his "Glossarium mediæ et infimæ latinitatis", had become attached to an allodial "seigneurie" in the Vendée. It was his grandson, François de La Trémoïlle (1505-1541), who succeeded Louis II in his titles, his father Charles, prince de Talmond (1486-1515), having been killed at the Battle of Marignano. He was taken prisoner at the battle of Pavia at which his grandfather was killed, but was subsequently ransomed. François wed the heiress Anne de Laval in 1521, who eventually brought to their descendants the pretendership to a royal throne. Their two younger sons, George (died 1584) and Claude (died 1566) founded, respectively, the branches of the marquis d'Royan (extinct 1698) and of the ducs de Noirmoutier (extinct 1733).