On 13 January 2016, Sensi was signed by Serie A club Sassuolo. He would spend the first 6 months of the contract on loan with Cesena. He returned in Sassuolo in July 2016 ahead of 2016–17 season, making his Serie A debut by playing full 90 minutes in the opening championship match against Palermo, which ended in a 1–0 away win. His first top flight goal came later in October 2016 in a 2–1 home win over newly promoted side Crotone. Sensi concluded his first season at Mapei Stadium by playing 19 matches in all competitions, scoring only once. In the 2017–18 season, he scored two goals in 17 league appearances. Sensi was a protagonist in the 2018–19 season under manager Roberto De Zerbi, making 30 appearances between league and cup, netting twice in the process.