On 22 July 2015, Kononenko launched to the International Space Station as Soyuz Commander, together with NASA astronaut Kjell Lindgren and Kimiya Yui from the Japanese Aerospace Exploration Agency (JAXA) on Soyuz-TMA-17M. They spent 5 months on the International Space Station as members of the Expedition 44 and Expedition 45 Crews. The trio returned to Earth in rare night landing on 11 December 2015, when their Soyuz TMA-17M landed safely on the steppe of Kazakhstan. Kononenko spent 142 days in space on his third mission.