In the aftermath of the Nat Turner slave rebellion and other events, slavery emerged as an increasingly prominent political issue. Calhoun attacked Van Buren, saying that he could not be trusted to protect Southern interests and accusing the sitting Vice President of affiliating with abolitionists. Van Buren defeated Harrison by a margin of 51.4% to 48.6% in the North, and he defeated White by a similar margin of 50.7% to 49.3% in the South.