Edward Worthington (1750-1754–1804) was an 18th-early 19th century American frontiersman, longhunter, surveyor, soldier, pioneer, and state militia officer who explored and later helped settle the Kentucky frontier. A veteran of the American Revolution and the Indian Wars, he also served as a paymaster under George Rogers Clark during the Illinois campaign. His grandson, William H. Worthington, was an officer with the 5th Iowa Volunteer Infantry Regiment during the American Civil War. Historian and author, Kathleen L. Lodwick is a direct descendant of Edward Worthington.