On 4 January 2010, Pandev signed a four-and-a-half year contract with Inter Milan, wearing the number 27 shirt. He made his Inter debut as a starter in the 1–0 away win against Chievo on 6 January. His first two games for the "Nerazzurri" resulted in him contributing to both winners — setting up Mario Balotelli against Chievo and setting up Walter Samuel to score a last minute winner against Siena. He opened his scoring account in his third appearance for the club, pulling a goal back for Inter in an eventual 2–2 draw at Bari. Pandev was the main protagonist in the 2–0 victory over local rivals Milan as he first assisted Diego Milito with an overhead cross and scored a curling freekick to complete the win. He continued with his solid performances throughout the season, being an important player in Inter's winning of the first treble in the history of Italian football. Inter won their 5th consecutive Serie A title by defeating Siena in the final match, and also defeated Roma at Stadio Olimpico to win the Coppa Italia. On 22 May 2010, Inter won the UEFA Champions League in the final against Bayern Munich, with Pandev playing for 79 minutes and becoming the third Macedonian football player in history to ever win this championship.