In the 2010 National League Division Series against the Braves, Sanchez batted .125 but scored two runs. In Game 3, Sanchez batted in the ninth inning with two outs and the Giants down 2–1. Craig Kimbrel got two strikes on him, but Sanchez hit a single, then later scored the tying run as the Giants came back to win the game 3–2 that inning. The Giants defeated Atlanta in four games. He batted .320 in the 2010 National League Championship Series against the Philadelphia Phillies, with three multi-hit games as the Giants beat the Phillies in six games. In Game 1 of the 2010 World Series against the Texas Rangers, he became the first player in history to collect three doubles in his first three World Series at-bats during the Giants' 11–7 victory over the Rangers. "I think it’s crazy to have my name up there with all the guys that have played in the World Series that have done that before," he said. "Obviously for no one to have done that yet, I think it’s something special. For just a little guy like me to go out there and be able to do it. But getting the win was the most important thing, but that’s something special and something I can enjoy along with the win." Sanchez had four hits total in that game, and he had two more in the Series. In Game 4, he made a leaping catch of a line drive off the bat of Jeff Francoeur with two outs in the second inning, falling on his back but hanging onto the ball. The Giants won that game 4–0, then won the series in five games, earning their first World Series title since 1954.