On 8 December 2016, Mkhitaryan scored his first goal for the club, away against Zorya Luhansk, in Manchester United's last group match of the Europa League. Three days later, in United's next game, Mkhitaryan scored his first Premier League goal (and his first goal at Old Trafford) in a 1–0 victory over Tottenham Hotspur; however, he left the game in the second half after suffering an ankle injury in a tackle by Danny Rose. He returned from this injury two matches later, coming off the bench to score United's third goal against Sunderland, a scorpion kick which he described as being the best goal he had ever scored. He scored in the 2017 Europa League final to help Manchester United beat Ajax 2–0, and became the first Armenian to win a major European trophy.