In 1609, the Statutes of Iona attempted to enforce the Scottish reformation in the highlands, but the Rough Bounds remained resolutely Roman Catholic, and sided with the Royalists during the Civil War. In the following century, the area became a hotbed of Jacobite sympathy, and even resorted to burning down Tioram Castle, in order to prevent it falling into anti-Jacobite hands. Following the failure of the Jacobite rising of 1745, it was the last part of Scotland in which Bonnie Prince Charlie found sanctuary, and the one from which he left for exile in France, on 20 September 1746.