Ernest Ndjissipou (born 24 September 1972, in Bangui) is a retired Central African long-distance and marathon runner. He represented the Central African Republic in three editions of the Olympic Games (1992, 1996, and 2004), and has also set both a national record and a personal best of 2:18:06 in men's marathon from the 2003 IAAF World Championships in Paris, France.