During World War I, Mittwoch was the head of the German Nachrichtenstelle für den Orient from 1916 until 1918. After the agency initially employed people who advocated Jihad and violence against the Western powers, Mittwoch hired more liberal and cosmopolitan writers and intellectuals for the Nachrichtenstelle such as the Swiss Max Rudolf Kaufmann (Mittwoch hired him for the Nachrichtenstelle, after he arrested, briefly imprisoned and deported from Turkey because Turkish intelligence had found letter of Kaufmann criticizing German-Turkish militarism and jingoism), the Social Democrat Friedrich Schrader and the Zionist Nahum Goldmann. Schrader and Kaufmann were correspondents for the Jewish-owned liberal Frankfurter Zeitung and close associates of , one of the sharpest critics of German collaboration with the genocidal politics of the Young Turks.