Vizcaíno appeared in 73 games for the Yankees, hitting .276 with 10 runs batted in, earning a spot on the Yankees postseason roster. In the American League Division Series, he scored one run as a pinch-runner. In the American League Championship Series, he played in four games collecting two hits, three runs, and 2 runs batted in (along with two stolen bases) as the Yankees defeated the Seattle Mariners. Vizcaíno played in four of the five games in the 2000 World Series against the New York Mets. He is most known for his dramatic hit on October 21, 2000, in Game 1. In the bottom of the 12th inning of the then longest game in World Series history, Vizcaíno hit the game-winning RBI single. He earned a World Series ring when the Yankees defeated the Mets in five games. On November 1, he was granted free agency.