The Reds signed Latos to a two-year contract worth $11.5 million for the 2013 and 2014 seasons. Latos had a 21-game streak without a loss, extending from August 2012 to June 2013. He finished the 2013 season with a 14–7 win–loss record and a 3.16 ERA in innings pitched. Though he suffered an abdominal strain on June 30, he continued to pitch without missing any starts. He revealed the injury after a poor outing against the Pittsburgh Pirates in September. The Reds reached the 2013 National League Wild Card Game, opposing Pittsburgh. Reds' manager Dusty Baker wanted to start Latos for that game, but a bone spur in his elbow prevented him from being available. Baker chose Cueto as his starter. The Reds lost the game, ending their season.