The Papal States covered central Italy and were expanded by warrior popes such as Julius II. Italy, although divided in several states, saw a period of great prosperity during the Renaissance. In 1420, Pope Martin V re-established Rome as the sole seat of the Catholic Church and put an end to the Western Schism. Between 1494 and the second half of the 16th century, Italy was the battleground of Europe. Competing monarchs, including Popes, clashed for European supremacy in Italy. In the late 1500s and early 1600s, the Papacy led the Counter-reformation effort. Pontiffs such as Paul III and Pius V, exercised great diplomatic influence in Europe. Popes mediated the Peace of Nice (1538) between the Holy Roman Empire and France, as well as the Peace of Vervins (1598) between France and Spain. In the new world, thousands were converted to Catholicism by missionaries. Many European and Italian states (such as the Republic of Venice and the Republic of Genoa) were brought by the Papacy into "Holy Leagues" to defeat the Ottoman Empire: defeats occurred in Rhodes (1522), Preveza (1538), Budapes (1541), Algiers (1541), whereas victories took place at Vienna (1529), Tunis (1535), Lepanto (1571), and Malta (1565). Similarly, the Church supported catholic leagues in the European wars of religion fought in France, the Low Countries, and Germany. France remained catholic following the conversion of the French king, whereas half of the Low Countries were lost to Protestantism. It was the 30 years war that ultimately ended the status of the Papacy as a great power. Although the Pope declared Westphalia "null and void", European rulers refused to obey Papal orders and even rejected Papal mediation at the negotiations of the treaty.