During the Irish Confederate Wars (1641–1652), the fort at Duncannon was initially occupied by English soldiers and used as a base for an attack on nearby Redmond's Hall (now Loftus Hall). During this period it was besieged three times. In 1645, it was taken by an Irish Confederate army under general Thomas Preston. Its English garrison surrendered after lengthy bombardment, during which their second in command Larcan was killed, and a ship, "The Great Lewis", trying to bring supplies to the garrison was sunk with the loss of 200 lives (see Siege of Duncannon). During the Cromwellian conquest of Ireland, Duncannon was besieged again, as part of the Siege of Waterford, firstly in November 1649 by Oliver Cromwell and Michael Jones in 1649. The fort's Irish garrison held out, and the siege was abandoned in December of that year. However, in July 1650, Henry Ireton renewed the siege, and the fort and town surrendered after the fall of Waterford, but before their food and supplies had run out.