The regiment was created as a result of the Treaty of Kurukove, between the Zaporozhian Cossacks and the Polish–Lithuanian Commonwealth which led the establishment of six regiments of registered cossacks that existed before the Khmelnytsky Uprising. The regiment occupied a large amount area on the Right-bank Ukraine, and bordered by the Kyiv Regiment to the east, Korsun regiment by the south, and the Uman regiment to the west. In 1648 the regiment was incorporated into the Cossack Hetmanate when the Khmelnytsky uprising occurred. Following the signing of the treaty of Zboriv in 1649 it consisted of a total of 23 sotnias, and had 2,990 registered Cossacks. During the uprising the regiment took part in battles in batih, and Starokostiantyniv.