Zhou got to the last 16 of the 2016 International Championship with wins over Anthony McGill and Mark Joyce, but lost 6–2 to John Higgins. He progressed through to the same stage of the UK Championship by defeating his World Cup partner Yan Bingtao 6–5 and was beaten 6–2 by Shaun Murphy. Zhou dropped just two frames in four matches at the Welsh Open to reach his first ranking event quarter-final, but was whitewashed 5–0 by Scott Donaldson. He beat Christopher Keogan 10–5, Ian Preece 10–8 and Ben Woollaston 10–9 to qualify for his first World Championship and said he hoped to draw Ronnie O'Sullivan in the opening round. Instead he faced Ding Junhui and was defeated 10–5. Zhou broke in to the top 32 in the world rankings for the first time at the end of the season.