On 26 April 1959, Tajuddin married Syeda Zohra Khatun (d. 20 December 2013) a daughter of a professor. They had four children, three daughters—Sharmin Ahmad (Reepi), Simeen Hussain Rimi, Mahjabin Ahmad (Mimi) and one son Tanjim Ahmad Sohel Taj. Zohra was highly supportive of Tajuddin's political activism but had no involvement in politics during his lifetime. After the assassinations of Sheikh Mujib and Tajuddin, she reorganised and led the Awami League from 1975 to 1981.