On 23 December 1941, CruDiv6 supported the second assault on Wake Island in which Japanese troops were able to capture the island after the intense Battle of Wake Island. In May 1942, from CruDiv6, Gotō commanded an element of the "Main Body Support Force," providing cover, along with the light aircraft carrier , for the Operation Mo offensive, including landings on Tulagi and an attempted assault on Port Moresby, New Guinea that resulted in the Battle of the Coral Sea. During the battle, U.S. aircraft attacked and sank "Shōhō", with Gotō's cruisers located too far away to provide anti-aircraft protection for the carrier, for the loss of .