Liprandi married Maria Fedorovna Talyzina (1808–1843) in 1833. She was the daughter of Lieutenant General F. I. Talyzin. Their son, Rafail Pavlovich (1838-1909) was a Major General of the General Staff. He fought with distinction in the Russo-Turkish War (1877–1878), including at the Battle of Shipka Pass, for which he was awarded gold weapons and the Order of St. George 4th class.