On 23 May 2015, he was promoted as head coach of Pescara after the dismissal of Marco Baroni with only one game remaining, a home match against Livorno (coached by former Italy teammate Christian Panucci), with both teams still involved in the race for a promotion playoff spot. The game ended with a 3–0 win for Pescara, which qualified the team to the Serie A promotion playoffs. On 9 June 2016, Oddo led Pescara to Serie A promotion after beating out Trapani 3–1 on aggregate in the Serie B promotion play-off final. On 15 July 2016, Pescara extended Oddo's contract by three years, keeping him as manager of the club until June 2019. He was sacked on 14 February 2017.