Melis earned her last cap on 9 March 2016 in a home game against Sweden, a qualification game for the 2016 Olympics. She scored her last goal, her 59th, in the penultimate match of her career, against Norway. Hers was the only Dutch goal in the 4–1 loss. Her highest number of goals in one match was four, scored in a 6–0 win over Serbia in 2011. In September 2013, she scored a hat-trick against Albania during 2015 FIFA Women's World Cup qualification. Serbia and Switzerland are the teams against which she has scored the most, six goals total, from two and six games respectively. Four of her 59 goals came from penalties; 25 were scored on home soil. Her most productive year was 2011 with 10 goals from 12 games. For nearly nine years Melis held the all-time goalscoring record, until 15 June 2019, when Vivianne Miedema surpassed Melis by scoring her 60th goal in a 3–1 win over Cameroon at a group stage match at the FIFA World Cup Finals in France. As of December 2020 Melis ranked second on the all-time goalscoring list for the Netherlands women's football team.