He ran as head of the Podemos list in the May 2015 regional election in Madrid; elected member of the regional legislature, he became the spokesperson of the Podemos parliamentary group in the chamber. In December 2016, after the Ramón Espinar's victory in the Podemos regional primaries in Madrid in November 2016, López, considered a member of the "errejonista" faction, was replaced as spokesperson of the parliamentary group by Lorena Ruiz-Huerta.