Perhaps the most notable example was the Chernobyl nuclear reactor accident in Ukraine in April, 1986. The reactor began to overheat at about 1:30am because critical cooling valves were shut off. The shiftworkers, sleep-deprived and likely experiencing microsleeps with consequent reduced decision-making ability, mistakenly disabled the cooling system, causing the reactor to overheat. As a result, there was a destructive explosion, resulting in numerous radiation-related injuries and casualties.