The following commander of the unit would be Militia Major Emeterio Rodríguez Sanabria. Under his command the 49th Mixed Brigade took part in the Battle of Teruel and later in the Battle of Alfambra, where its ranks were heavily depleted while trying to conquer 961 Hill "(Cota 961)" on 7 and 10 January. Only in the first day it suffered 213 casualties. On 3 April the unit found itself at the breaking point of the front which was submitted to vehement attacks by the forces of rebel general Antonio Aranda and it had to withdraw from the first line after being badly shattered. On 30 May the 49th Mixed Brigade was again very hard hit fighting the rebel Levante Offensive in the Ares del Maestrat-La Jana sector. Towards the beginning of July the much depleted unit was defending Castellón under the command of Infantry Major Amado Granell, but on the 15 it was definitively withdrawn for its reorganization. Following the Levante battles Militia Major Fernando Gil Ferragut became the new leader of the unit and the brigade was transferred to the less active southern front of the Levantine Army.