Enderlein luged at the FIL World Luge Championships 1965 on 6 and 7 February in Davos and won her first World Championship title with an advantage of over one second after four heats, ahead of Petra Tierlich, Ilse Geisler and Barbara Winter. A week later at the 1965 GDR Championships in Oberhof she won with a one-second advantage ahead of Petra Tierlich and Ilse Geisler, despite disqualification in the second heatonly two of the three heats were counted. Because of her consistent achievements, Enderlein was ranked third in the vote for East German Sportswoman of the Year, behind Hannelore Suppe and Gabriele Seyfert. The 1966 Luge Championships on the Spießbergbahn in Friedrichroda was cancelled due to föhn winds and the associated thaw; there were also no national championships that year. Enderlein inaugurated a new open-air public bath in Raschau on 22 June 1966.