Bose co-wrote the Bedabrata Pain directed film Chittagong, a period drama that chronicles the 1930 Chittagong armoury raid. Her 2014 production, "Margarita, with a Straw", starring Kalki Koechlin as a girl with cerebral palsy, premiered at 2014 Toronto International Film Festival to critical acclaim. The film won the NETPAC Award for Best Asian Film at the event. She had begun working on the script a year after the death of her son; the film's initial draft won the Sundance Mahindra Global Filmmaker Award, at the 2012 Sundance Film Festival. Bose was inspired to make the film by her real life experiences of studying in New York, her relationship with her cousin Malini Chib who has cerebral palsy, and her and Chib's sexuality as queer and disabled people respectively. The film was originally rejected by the censor board in India, but won an appeal and was released shortly after the ban on homosexuality in India was lifted.