Little Cacapon is an unincorporated community in Hampshire County in the U.S. state of West Virginia. Little Cacapon is located at the mouth of the Little Cacapon River on the Potomac, east of Okonoko. Okonoko-Little Cacapon Road (West Virginia Secondary Route 2/7) and Spring Gap-Neals Run Road (West Virginia Secondary Route 2) converge south of Little Cacapon. Because of its key location at the mouth of the Little Cacapon and on the Baltimore and Ohio Railroad, Little Cacapon played important roles in both the French and Indian and American Civil Wars. Generally pronounced . Sometimes, despite the current spelling of the word (derived from local Native American for "medicine water") some locals say .