At international level, Zambrotta won 98 caps for the Italy national team, playing at three FIFA World Cups, three UEFA European Championship, the 2009 FIFA Confederations Cup and the 2000 Summer Olympics. He was part of their side that reached the Euro 2000 final, and he was also selected to the Euro 2004 Team of the Tournament. He was most notably a key member of the starting lineup of the Italian squad that won the 2006 World Cup, and he was selected in the Team of the Tournament for his performances.