Prifti's involvement in the War of Liberation began with his enrollment in the 1st Brigade. He was later assigned as a Commisar in the 2nd Division and by October 1944 was in charge of its political section. From December 1944 to March 1945 Prifti served as Commisar of the 1st Division. The following month, he was named as Secretary General of the Government. From 1947 onwards, he held several diplomatic posts, first as ambassador to the Soviet Union and later China. He also served as Deputy Minister of Foreign Affairs. Prifti was elected a member of the People's Assembly from 1952-1960 and served as Chairman of the Assembly from 1951-1954. From 1961-1975 he was director of the Pedagogical Institute of Shkodër. He died on March 16, 1986 in Tirana.