After the Spanish conquest of Iberian Navarre in 1512, he was appointed in 1521 by Henry II of Navarre commander of a Gascoigne-Navarrese army, to try for the third time to recapture the Kingdom of Navarre. At first, the campaign was successful and Navarre was recaptured in May, but on June 30, 1521, Lesparre's army suffered a crushing defeat in the Battle of Noáin against the Spanish. 5.000 men were lost and Lesparre himself was wounded and captured, but later released for ransom.