After its monks were slaughtered by Turks in 1821 during the Greek Revolution of Independence, Toplou was again deserted until 1828. In 1866, during the massive Cretan revolt against the Turks, it was once again devastated. During the German occupation of 1941-44, Toplou was providing shelter to resistance fighters and housed their wireless radio. When this was discovered by the Germans, the abbot and two monks were tortured and executed.