Chisnall's third round 2016 World Championship game with Peter Wright went to a deciding set. Chisnall missed one match dart, but then took out a 130 checkout to save the game after Wright had missed a match dart of his own. However, Wright broke once more and, after Chisnall missed double top to complete a 125 finish, he won the match 4–3. The defeat meant that Chisnall is yet to reach a quarter-final in a PDC World Championship. Chisnall recovered from an 8–0 deficit in the first round of the Masters to beat Robert Thornton 10–9 and then came past Kim Huybrechts 10–5 and James Wade 11–6 to reach the final. However, he would lose his third PDC major final 11–6 to Michael van Gerwen. He lost 9–7 to Gary Anderson in the third round of the UK Open after being 7–5 up. After whitewashing Thornton 7–0 on the opening night of the Premier League, Chisnall could not pick another win from his next eight matches to finish 9th in the table and be relegated from the competition.