The settlement of Agryz first appeared in historical records in 1646. After the suppression of Pugachev's uprising in 1775, Agryz became part of the Sarapulsky county (uyezd) within the Vyatka province. In 1914-1915, a railway connecting Kazan with the Urals was built near the Agryz settlement. Since the founding of the railway station, Agryz has become one of the largest railway hubs in the region. The Agryzsky district was first formed in 1924. In 1963, the district's territory was included in the Yelabuga agricultural region, but a year later Agryz would be restored within its former borders.