The unit was tasked from September to October 2005 to combat the potential deadly spread of infectious diseases from insect bites due to the flooding in the aftermath of Hurricanes Katrina and Rita in late August and in September 2005. When the mission concluded, the 910th helped the people of Louisiana and Texas by spraying more than 2.8 million acres. This equates to 4,501 square miles, or approximately an area the size of Connecticut. This was the largest aerial spray tasking since the mission's conception in 1973.