Milik signed with Napoli on 1 August 2016; his €35 million transfer was officially confirmed by the club the following afternoon. He made his club debut on 27 August, scoring his first two goals for Napoli in a 4–2 home win over Milan in Serie A. He scored braces again against Dynamo Kyiv and Bologna in September, but on 8 October, Milik tore his anterior cruciate ligament in a Polish international fixture against Denmark and was expected to be out for the rest of the season. However, as of 12 February 2017, he resumed playing and was fielded again on 15 February in the Champions League match against Real Madrid.