After the Red Sox victory in the ALCS, Lester was selected to start Game 1 of the 2013 World Series against the St. Louis Cardinals. Lester pitched to an 8–1 victory over St. Louis starter Adam Wainwright. Lester then went on to a Game 5 win again over Wainwright giving the Red Sox a series lead of 3–2. The Red Sox won the series in six games.