During the 2009 summer transfer window, Zokora signed for Spanish La Liga side Sevilla for an undisclosed fee, including a reported €30 million release clause. He made his debut for the club on 30 August 2009 in the first round of the 2009–10 La Liga season in a 2–0 loss to Valencia, entering as a 21st-minute substitute for the injured Romaric. In his first season in Andalusia, Zokora managed to help take Sevilla back into the UEFA Champions League after finishing La Liga in fourth position. In addition to the Liga success, he helped his side claim their fifth Copa del Rey title by defeating 2010 UEFA Europa League winners Atlético Madrid 2–0 in the final at Camp Nou.