Losing both Cleaves and Peterson to graduation following the season, MSU still began the 2000–01 season ranked No. 3 in the country. Led by sophomore Jason Richardson, freshmen Zach Randolph, and seniors Charlie Bell and Andre Hutson, the Spartans finished the non-conference schedule undefeated and ranked No.1 in the country. MSU again earned a share the Big Ten title, their fourth consecutive, with a 13–3 conference record. They suffered a surprise defeat by Penn State in the Big Ten Tournament in their attempt to win the tournament for the third consecutive year. They received their third consecutive No. 1 seed, in the South Region of the NCAA Tournament. Seeking a repeat National Championship, MSU easily dispatched Alabama State and Fresno State to reach the Sweet Sixteen for the fourth consecutive year. A win over Gonzaga and Temple led to the school's third straight trip to the Final Four. However, they were unable to repeat as National Champions, losing to Arizona in the National Semifinal. Following the season, Randolph and Richardson each left school early and declared for the NBA Draft.