On 19 June 2017, following a lengthy transfer saga which had Lozano linked to a number of European clubs, including Manchester United, Manchester City, Benfica and Ajax, it was announced that Dutch club PSV Eindhoven had secured the signing of Lozano on a six-year contract. He temporarily left the Mexican national side which was in Russia for the Confederations Cup in order to secure the transfer. He became the fifth Mexican player to join PSV.