Ganesh Ghosh hailed from Chittagong, now in Bangladesh. In 1922, he took admission in the Bengal Technical Institute in Calcutta. Later, he became a member of the Chittagong Jugantar party. He participated in the Chittagong armoury raid, along with Surya Sen and other revolutionaries on 18 April 1930. He fled from Chittagong and took shelter in Chandannagar, Hooghly. After few days police commissioner Charles Tegart attacked the safe house of them in Chandannagar and arrested him. One young fellow revolutionary Jiban Ghoshal Alias Makhan killed by the police at time of arrest operation.