The IV Scythia took part in Trajan's Parthian Campaign, As well as the war against the Parthians between 161 and 166. Between AD 181 and 183 Septimius Severus acted as the commander of the Eastern legions, and he later relied on the power of said legions to become emperor. The Legion's former commander, now Emperor, Semptimus Severus would lead another campaign against the Parthians. This campaign also used the IV Scythia. The IV Scythica was most likely involved in the eastern campaign of Caracalla. In 219.