Antigua Guatemala Cathedral () is a Roman Catholic church in Antigua Guatemala, Guatemala. The original church was built around 1541, but suffered several earthquakes throughout its history, and the first church building was demolished in 1669. The cathedral was rebuilt and consecrated in 1680. By 1743 the cathedral was one of the largest in Central America. However, the devastating 1773 Guatemala earthquake seriously damaged much of the building, though the two towers at the front remained largely intact. These have undergone restoration work, and the cathedral has been partly rebuilt