Lazio were drawn to face Romanian champions Dinamo București in the Champions League qualifiers and, in the second leg, Del Nero proved decisive. Having only managed a 1–1 draw in Rome, the biancocelesti travelled to Bucharest needing a win and Del Nero won an early penalty for the first goal before setting up the second, with Lazio going on to win 3–1 and qualify for the group stage. Unfortunately for the Ligurian, he did not take any part in the group phase, and only managed five Serie A appearances due to injury. At the end of the 2007–08 season, Del Nero underwent an operation in Finland for plantar fasciitis.