Moyer bounced back in the Mariners' 116-win 2001 season. He earned 20 wins, ranked tied for second in the American League, and his 3.43 ERA was sixth in the AL. He earned his 150th career win against the Texas Rangers on September 24. He became only the second Mariner in history to win 20 games on October 5, former teammate Randy Johnson being the other. Moyer went 3–0 with a 1.89 ERA in the postseason. He won Games 2 and 5 for the Mariners against the Cleveland Indians in the ALDS. Moyer also won Game 3 against the New York Yankees in the ALCS. However, this would be Seattle's only victory in the series, as New York defeated them in five games to advance to their fourth consecutive World Series.