San José de los Ramos was founded in 1844 when the first houses were built near the Júcaro railway. At the centre was the church or chapel of the same name. The original name of the community was Cunagua, a native word which is now one of the neighbourhoods. In 1527, it was sold to Andrés Recio and took the name Las Ciegas (The Blind Women) before becoming San José de los Ramos. In 1879, San José became a municipality (ayuntamiento). In 1902, it was annexed to Colón but was separated again in 1910. In 1940, it became an integral part of the judicial and fiscal district of Colón. In 1943, it consisted of the districts of Banagüises (also Managüises) with a population of 4,103, Cunagua, population 1,187, and San José de los Ramos, population 3,916. In the War of Independence, more than a hundred of its citizens took up arms against Spain.