By 2011, Ledesma announced he would retire at the end of the season, and his last professional club game was a 29–6 loss to in the semi-final of the 2010–11 Top 14 season. However, his career hadn't ended yet, for he was selected for his fourth World Cup campaign in 2011. Ledesma was one of the leaders of Los Pumas' pack, and helped his side finish the pool stage 2nd, losing only to England. In the quarter-final, saw Argentina face hosts New Zealand, who won the game 33–10. When Ledesma came off at the 70th minute, it was his final appearance for his nation. During the World Cup, The Daily Telegraph considered Ledesma as one of the best in his position at the 2011 World Cup.