In New York City, in 1842, she married Dr. Mayo Gerrish Smith, son of Foster Smith. Soon after her marriage, she came with her husband to Newburyport, and lived for some months in the family of her father-in-law, on Smith's court, removing later to a dwelling house on Essex street, where her husband had an office fitted up for his use as a surgeon dentist. After the discovery of gold in California, in 1849, Dr. Smith went to the Pacific coast, and remained there seven years.