After the death of Queen Isabella in 1504, and her exclusion of Ferdinand from a further role in Castile, Ferdinand married Germaine de Foix in 1505, cementing an alliance with France. Had that couple had a surviving heir, likely the Crown of Aragon would have been split from Castile, which was inherited by Charles, Ferdinand and Isabella's grandson. Ferdinand joined the League of Cambrai against Venice in 1508. In 1511, he became part of the Holy League against France, seeing a chance at taking both Milan—to which he held a dynastic claim—and Navarre. In 1516, France agreed to a truce that left Milan in its control and recognized Spanish control of Upper Navarre, which had effectively been a Spanish protectorate following a series of treaties in 1488, 1491, 1493, and 1495.