Conflict in the region intensified after the independence of the former Spanish and Portuguese colonies in the first quarter of the 19th century. Interests in the territories and the navigation rights over the Platine region played a major role in many armed conflicts throughout the century, including the Argentine civil wars, the Cisplatine and Platine wars, and the Paraguayan War. The river was blockaded by France and Britain in 1838–1840 and 1845–1850.