"Success" was then employed on the blockade of Malta, during which, on 18 February 1800, she played a crucial role in the capture of the French 74 "Généreux", flagship of Rear-Admiral Perrée, Commander-in-Chief of the French naval forces in the Mediterranean, by raking her several times, before she was captured by the ships of the line and . "Success" made several subsequent captures during the siege. On 28 April 1800 she took the French polacca "La Bellone", from Valletta bound for Marseille, laden with cotton. On 25 June she captured the French aviso (or "Intraprenant"), under the command of "Enseigne" Louis Podesta, with four guns and a crew of 36 men, carrying provisions from Santa Messa to Valletta. The next day "Success" captured another aviso, , under "Enseigne" Jean Pierre Louis Barallier, with the same armament, establishment, and mission as "Entreprenant". Unfortunately for "Success", she had to share the prize money with a large number of other British warships. The same day she captured the French felucca "Fortune", which was apparently unarmed, but carrying provisions on the same route as the two avisos. During the night of 24 August, two French frigates, and , sailed from Valletta harbour, in an attempt to evade the British blockade. However they were seen and pursued, and after chase of several hours, and a running fight with "Success", the "Diane" surrendered to her, and "Northumberland". She mounted 42 guns, 18- and 9-pounders, but had a crew of only 114, having left the rest onshore as part of the garrison. "Justice", however, escaped under cover of darkness. Finally, on 5 February 1801 she captured the Spanish felucca "La Virgen del Rosario".