In 573, during Khosrow I's offensive during the Byzantine–Sasanian War of 572–591, the Sasanian King ordered General Adarmahan to cross the Euphrates near Circesium in order to attack the eastern Byzantine provinces from there. In 580, Circesium was turned into the garrison base for Emperor Maurice's offensive during the Byzantine–Sasanian War of 572–591. During the flight of Khosrow II (590–628) in 590, the latter was briefly sheltered by the Byzantine garrison commander of Circesium, Probus, before moving to Hierapolis.