Nedow changed college after his first year and began studying at DePaul University, gaining a place on their DePaul Blue Demons track team. There he worked under coach Dave Dopek, a former NCAA indoor champion. He was third in the shot put at the Big East Conference indoor meet. Outdoors he was fourth in the shot put and sixth in the discus at the Big East Championships, then was a finalist at the NCAA Men's Outdoor Track and Field Championship. He ended the season with bests of for the shot put and for the discus. He was a much improved athlete in 2011 and threw a personal record of in January. He won the Big East shot put titles indoors and out, as well as a fourth-place finish in the discus throw at the outdoor meet. His appearance at the NCAA Men's Indoor Track and Field Championship broke a nine-year absence for DePaul University, although Nedow failed to record a valid mark. He placed in the top twenty of both throws at the 2011 NCAA Outdoor meet. He began to establish himself at national level, coming second in the shot put at the Canadian Track and Field Championships. He made his second international appearance through the Summer Universiade and he finished twelfth at the event in Shenzhen, China.