For the 2007 America's Cup, Spithill was chosen by Francesco De Angelis, whom he had beaten in the 2003 Louis Vuitton quarter-finals, as his heir as helmsman of Luna Rossa Challenge. Spithill was a mainstay of the team, which he led to the final of the Louis Vuitton Cup 2007 after beating one of the favourites, Oracle BMW Racing, 5–1 in the semifinals. He earned the nickname of "James Pitbull" among Italian fans because of his aggressive tactics during the pre-start phase of the races. He is the protagonist of what is arguably remembered as the greatest pre-start in the history of the America's Cup, forcing two penalties to BMW Oracle skipper Chris Dickson in race five of the Louis Vuitton Cup 2007, causing Dickson's resignation a few days later. Spithill went on to lose 5–0 to Emirates Team New Zealand in the 2007 Louis Vuitton Cup final.