In September, the ship took part in full-scale amphibious exercises in California, departing from San Diego on 17 October for her first deployment to the western Pacific. However, as the crisis flared up on 19 October over the introduction of offensive missiles into Cuba, "Iwo Jima" returned to San Diego, embarked Marines 22 October to 27 October, and departed quickly for the Caribbean. As part of America's powerful and mobile force afloat, she cruised in a "ready" status until December brought an easing of the Cuban situation. She arrived in San Diego on 13 December.