"Ro-41" departed Tokuyama on 24 December 1944 for her fifth war patrol, assigned a patrol area northeast of the Philippine Islands. By 4 January 1945 she was operating west of Luzon. U.S. forces entered Lingayen Gulf and U.S. forces landed on Luzon on 9 January 1945, but "Ro-41" did not engage any Allied forces during her patrol. She arrived at Kure on 31 January 1945.