Ganassi moved to Honda engines for the 2006 season, when Dixon was partnered with Englishman Dan Wheldon, the 2005 Indianapolis 500 winner and IRL series champion. Before the IRL season even started, they successfully combined as a one-car team (with Casey Mears) to win the 24 Hours of Daytona. Dixon repeated his 2005 Indy Grand Prix win at Watkins Glen, and became the first driver to win an IRL race run in wet conditions. At Nashville Superspeedway, he won the Gibson Guitar Trophy by a couple of car lengths over his teammate Wheldon. He finished fourth in the standings, completing a series-high 2,504 of a possible 2,510 laps and being the only driver to finish every race, and finishing just 15 points behind Sam Hornish Jr. and Wheldon.