In 1999 it moved from the Arts Centre into a larger gallery space in the Old Post Office Building on 209 Tuam Street. The Christchurch earthquakes forced a temporary relocation to Sandyford Street in Sydenham under recently appointed director Stephen Cleland. In 2013 the gallery returned to 209 Tuam Street with new director Melanie Oliver, formerly of Enjoy and the Govett-Brewster Gallery. Since Oliver left in 2016 to become Senior Curator at the Dowse, the Physics Room has been run by Jamie Hanton, former director of the Blue Oyster in Dunedin. In January 2018 the gallery relocated to 49–59 Worcester Boulevard.