"Quiberon" first served on North Atlantic convoy escort duty, operating out of Scapa Flow. She was assigned to support the Allied landings in North Africa in October 1942. On 28 November, "Quiberon" attacked and sank the Italian submarine off the Tunisian coast. After this, the destroyer was assigned to "Force Q", which was based at Bone and consisted of three cruisers and two other Q-class destroyers.