In 2010 Hunter-Reay began to drive for Andretti Autosport in a part-time schedule that would consist of all races through the Indianapolis 500. Hunter-Reay would drive the #37 Izod Dallara IR07-Ilmor-Indy V8 HI7R. At the season-opening São Paulo Indy 300 on the Streets of São Paulo Hunter-Reay started 4th and would lead for 20 laps, only to be passed by Will Power on lap 58 of 61. Three races later at the Toyota Grand Prix of Long Beach on the Streets of Long Beach Hunter-Reay started 2nd, set the fastest race lap and led for 64 of 85 laps to win the race. Following the race Hunter-Reay was ranked 3rd in points. At the next race, the RoadRunner Turbo Indy 300 at Kansas Speedway Hunter-Reay started 22nd and finished 5th. At the Indianapolis 500 Hunter-Reay qualified in a disappointing 17th place. In the race Hunter-Reay was on his way to a top 10 finish when on lap 199 in turn 3 he ran out of fuel causing Mike Conway to drive over the left side of Hunter-Reay's car and flip into the catchfence. At the same time Hunter-Reay lost control and drove into the wall. Hunter-Reay would finish in 18th place. Following the race Hunter-Reay was 5th in points and was given additional races. The team would race with additional sponsorship from Ethanol at select races. Prior to the Camping World Grand Prix at The Glen at Watkins Glen International Hunter-Reay was announced as a driver for all the remaining races. Hunter-Reay's best finish following Indianapolis was a 3rd at the Honda Indy Toronto at Exhibition Place. Hunter-Reay would finish 7th in the final point standings with 445 points.