A member of the Aspietes family, of noble Armenian origin, Constantine was probably a close relative of his contemporary Michael Aspietes, a distinguished general killed in 1176. Like his relative, Constantine too had earned distinction during Manuel I Komnenos' campaign against the Hungarians in 1167. The historian John Kinnamos records that he held the rank of "sebastos". He is next recorded as being active in 1190/1, during the Byzantine efforts to suppress the Bulgarian–Vlach rebellion of the brothers Peter and Ivan Asen. The historian Niketas Choniates records that, in an effort to sustain the troops and bolster their morale, Aspietes decided to distribute to them their delayed annual salaries. This act, however, enraged Emperor Isaac II Angelos, who saw in it almost an attempt to bribe the army to support Aspietes in overthrowing him. The emperor had Aspietes arrested and blinded, after which nothing further is known of him. He possibly died in the early years of the 13th century.