After the Invasion of Kuwait by Iraq in August 1990, the squadron was put on heightened readiness status awaiting possible deployment to the Gulf Region. At the time of the invasion, the 22nd Fighter Squadron was involved in the MSIP (Multi-Stage Improvement Program) upgrade of their F-15s and could not be deployed as a coherent unit. During December 1990, those aircraft that had completed upgrades, along with pilots and maintainers from the 22nd AMU (Aircraft Maintenance Unit), augmented their sister squadron, the 53rd Tactical Fighter Squadron, for deployment to Al Kharj AB, Saudi Arabia in support of Operations Desert Shield and later Desert Storm. In January 1991, many of the remaining aircraft, pilots and maintainers from the squadron deployed to Incirlik AB, Turkey along with their other sister squadron, the 525th Tactical Fighter Squadron, and the F-15s of the 32nd Tactical Fighter Squadron from Soesterberg AB, The Netherlands. Despite their reduced numbers, the 22nd's remaining pilots and maintainers at Bitburg continued to provide aircraft for the Zulu Alert facility, as well as provided support for non-squadron F-15s en route to the war zone. In all locations, the aircraft and personnel of the 22nd Tactical Fighter Squadron performed amazing feats under demanding conditions. Not a single F-15 aircraft was lost in combat during the war and several returned with credited kills. Aircraft tail number 79-0078, one of the squadron's Al Kharj deployed aircraft, was credited with two Mig-21 kills on 6 February 1991. Aircraft tail number 79-0022, one of the squadron's aircraft deployed to Incirlik, was credited with a Mig-23 kill on 28 January 1991 and is currently on display, along with other squadron memorabilia, at the Pueblo Weisbrod Aircraft Museum in Pueblo, Colorado. In March 1991, the Incirlik-deployed squadron returned to Bitburg AB. They were followed by the last members of the Al Kharj deployment in July 1991.