Dating from 1493, when the Spanish settled on the island, and officially from 5 August 1498, Santo Domingo became the oldest European city in the Americas. Bartholomew Columbus founded the settlement and named it La Nueva Isabela, after an earlier settlement in the north named after the Queen of Spain Isabella I. In 1495 it was renamed "Santo Domingo", in honor of Saint Dominic. Santo Domingo came to be known as the "Gateway to the Caribbean" and the chief town in Hispaniola from then on. Expeditions which led to Ponce de León's colonization of Puerto Rico, Diego Velázquez de Cuéllar's colonization of Cuba, Hernando Cortes' conquest of Mexico, and Vasco Núñez de Balboa's sighting of the Pacific Ocean were all launched from Santo Domingo.