In 2012, Guerrero was cast in "Orange is the New Black" in the role of Maritza Ramos, a Bronx-bred character with Colombian roots. For season 2, she was part of the cast that earned recognition for Outstanding Performance by an Ensemble in a Comedy Series at the 21st Screen Actors Guild Awards. The cast earned recognition for Outstanding Performance by an Ensemble in a Comedy Series again at the 22nd Screen Actors Guild Awards and 23rd Screen Actors Guild Awards. She remained part of the show through season 5. She returned for the final season in 2019.