It is believed that the soldiers of Tipu Sultan had tented at Nadayalparamba and Cholakamad in Kalpakanchery during the Mysorean conquest of Malabar. Some 20,000 people attended a Khilafat Movement meeting held in Kalpakanchery under the leadership of K. P. Kesava Menon just before the 1921 Malabar rebellion. During the uprising, a gang under the leadership of Odayappurath Chekkutty, who was also a great admirer and helper of the freedom fighter Mohammed Abdur Rahiman, from Kalpakanchery guarded the "Kizhake Kovilakam" (a seat of the ruling family of the Zamorin of Calicut) and Arya Vaidya Sala at Kottakkal. The Kalpakanchery Gram Panchayat was formed on 10 October 1940, as a part of the British Malabar District Board. It is one of the oldest Gram Panchayats in Malabar region. At the time of 1951 Census of India, the erstwhile Malabar District was divided into only 100 Gram Panchayats and Kalpakanchery was one among them.