In 1940, during the Nazi Occupation of Poland, German authorities established a Jewish ghetto in Piaseczno, in order to confine its Jewish population for the purpose of persecution and exploitation. The ghetto was liquidated in January 1941, when all its 2,500 inhabitants were transported in cattle trucks to the Warsaw Ghetto, the largest ghetto in all of Nazi occupied Europe with over 400,000 Jews crammed into an area of . From there, most victims were sent to Treblinka extermination camp.