Vázquez was originally kept out of the squad list by head coach Gennaro Gattuso and therefore ineligible to play in any matches for the first half of the 2013–14 Serie B season. However, he was reincluded into the first team roster by new boss Giuseppe Iachini later in January 2014 as a replacement to on-loan youngster Valerio Verre. Vázquez was then being used also as a second striker in a more regular basis, a role that gave him the opportunity to score goals. In the following 2014–15 Serie A campaign, Vázquez gained notoriety thanks to him forming a successful and effective striking partnership with Paulo Dybala, which saw them both finish the season as two of the top assist providers in the league, with ten assists. On 16 January 2015, he agreed a contract extension with Palermo lasting until 30 June 2019. On 15 May 2016, he scored in a 3–2 home win over Hellas Verona to help save Palermo from relegation at the conclusion of the 2015–16 Serie A season.