Rejoining the 5th Destroyer Flotilla on 5 June, the destroyer escorted Convoy WS19Z to Malta in Operation Harpoon, then did the same for the aircraft carrier HMS "Argus" for the return journey. After helping to cover Convoy PQ 17 to the Soviet Union, the destroyer was refitted at Liverpool from 20 July to 24 September. Following the completion of the refit, she escorted the aircraft carrier HMS "Furious" to Gibraltar, arriving on 25 October. After again escorting Convoys KMF1 and KMF2 for Operation Torch, she returned to Greenock on 19 November with Convoy MKF1(X). "Escapade" was repaired on the Thames between 27 November and 23 December, joining Escort Group B3 of the Western Approaches Command for convoy escort duty in the North Atlantic, on which she spent the next six months. This period included escort duty with Convoys HX 228, ONS 175, HX 232, and HX 239 during the defeat of the U-boat campaign in May 1943. Receiving the Hedgehog anti-submarine mortar during a refit at Cardiff between 3 June and 5 September, "Escapade" began escorting Convoy ONS 18 after a brief working up. While engaged in this duty off Northern Ireland on 20 September, she fired her Hedgehog at a submarine contact, but one of its projectiles prematurely exploded, killing fifteen ratings, and wounding ten others, one mortally, in addition to destroying 'B' gun, the Hedgehog and heavily damaging the bridge and wheelhouse. It took more than a year to repair "Escapade", which returned to duty on 30 December 1944.