Manuel Serifo Nhamadjo (25 March 1958 – 17 March 2020) was a Bissau-Guinean politician who served as President of the National People's Assembly of Guinea-Bissau. He was a candidate in the abortive 2012 presidential election, placing third in the first round. Following an April 2012 military coup, he was designated as Acting President as part of a transitional arrangement.