On May 12, 2013, Sale threw a one-hit shutout during a 3–0 Sox victory over the Los Angeles Angels of Anaheim. Sale took a perfect game into the seventh inning. With one out in the top of the seventh inning, Mike Trout singled up the middle for the only hit of the game. Sale finished the game with 7 strikeouts and no walks, allowing Trout as the only base runner. Sale began the 2013 season with a 6–8 record and a 2.85 ERA. He was named an All-Star for the 2nd season in a row. Sale came on to pitch for the 2nd and 3rd innings, allowing no hits, no runs, no walks and striking out two NL hitters. He was named the winning pitcher for the American League, which won the game 3–0.