She is also active as an indigenous rights activist on an international level, with a focus on protecting homes and land against corporate interests. She was part of a global call to stop fossil fuel extraction at the 2014 People’s Climate March. She was also among the delegates advocating for "Living Forests" protection at the global climate conferences COP20 and COP21, in Lima and Paris respectively. In the course of COP21, she drew attention to her people’s demands by sailing down the river Seine in Paris in a canoe from her village. In 2016, she was among a group of indigenous women from 7 nationalities that united to march in defense of indigenous rights and territories. Gualinga shed more light on the effects of climate change on the Kichwa people at the COP22 in Marrakech and encouraged the government to prioritize climate actions to reduce carbon emissions for the indigenous people. She was part of the Women’s Earth and Climate Action Network (WECAN), Amazon Watch and Sarayaku Delegation to COP23 in Bonn and a speaker at the event. Nina was also part of the WECAN delegation at the COP25 climate negotiations in Madrid in 2019. At the event, she called for the world to refrain from extracting fossil fuels and to listen to indigenous peoples, who have protected their lands for millennia, for solutions to the climate crisis: "If we don’t listen to indigenous peoples, if we don’t listen to indigenous women we are not going to get out of this crisis." She gave a lecture on Indigenous People of the Amazon: The Guardians of Our Future at IAAC Auditorium, Barcelona on 25th of February 2020.