On 20 August 2015, Alex Sandro joined Italian Serie A champions Juventus for €26 million on a five-year contract. He made his club debut on 12 September 2015 in a 1–1 home draw against Chievo in Serie A. Defending champions Juventus endured a difficult start to the season, and were in the bottom half of the table by late October. The club mounted a comeback that started with a last-gasp Turin derby win on 31 October, with the Brazilian left-back playing a key role in that upturn.