Guzan was unused at the 2010 FIFA World Cup and played no international games between that November and May 2012, when he came on as a substitute for Tim Howard near the end of a 5–1 friendly win over Scotland in Jacksonville. Howard took an international sabbatical after starting at the 2014 FIFA World Cup, during which Guzan was first-choice. At the 2015 CONCACAF Gold Cup, in which the United States came fourth, Guzan and Michael Bradley were the only two Americans to start every game; he won the Golden Glove. Howard returned to the team for 2016's Copa América Centenario, but Guzan kept his place in a run to the semi-finals.