In 1803 "Caroline" brought the news of the declaration of war with France to the East Indies where she would stay for the rest of her service. The ship's main role in the Indies was attacking the possessions of the French and their allies and as such she participated in a number of important events, including the Java campaign of 1806–1807 in which she fought the action of 18 October 1806. The frigate also played an active role in the Persian Gulf campaign of 1809, the invasion of the Spice Islands where her crew were instrumental in capturing Banda Neira, and the invasion of Java in 1811. After this "Caroline" returned home to be paid off at Portsmouth where she was hulked. Her last, and most successful, commander was Captain Sir Christopher Cole. "Caroline" was broken up at Deptford in 1815.