At the start of the War of the Second Coalition in 1798, the 2nd Dragoon Regiment fought in southwestern Germany as part of the Army of the Danube. In 1799, it fought in the Second Battle of Zurich, earning itself a battle honour. In 1800, the regiment was part of the Army of the Rhine, in Marshal Laurent de Gouvion Saint-Cyr's Centre Corps, fighting at the battles of Biberach and Hohenlinden. From 1801 to 1805, the regiment was stationed at towns in the Flanders region and Picardy.