Irina Ratushinskaya was born in Odessa, Ukraine on 4 March 1954. Her father, Boris Leonidovich Ratushinsky, was an engineer; her mother, Irina Valentinovna Ratushinskaya, was a teacher of Russian literature. Irina had one sister. Her mother's family originated from Poland: her maternal great-grandfather was deported from Poland to Siberia, shortly after the January 1863 Uprising against forced conscription into the Russian Imperial Army.