The regiment was deployed to the West Indies in late 1739 but returned in December 1740. It formed part of the Government army sent to defeat the Jacobite rising of 1745, participating in the Battle of Falkirk in January 1746 and in the Battle of Culloden in April 1746. At this period they were commonly known as "Blakeney's" Regiment after the colonel-in-chief. In 1751, the regiment was formally titled the 27th (Enniskillen) Regiment of Foot.