Yusuff Ali is very closely involved in many social, charitable and humanitarian activities both in India as well as in the Arab states of the Gulf. He has done various philanthropic activities across the globe. As part of its Global CSR policy, the LuLu Group joined hands with Dubai Cares and adopted schools in Gaza and Nepal. Yusuff Ali contributed and took initiative to open a multi-faith funeral centre for the Indian community in Sharjah that spread across 8.3 acres. He also took initiative to sell and promote organic products grown by the special needs community in UAE through LuLu Hypermarkets Yusuff Ali donated generously towards the Gujarat earthquake, Tsunami Relief Fund in Asia, and Typhoon and flood relief in other parts of the world. He also donated Rs 9.5 crores for relief and rehabilitation of Kerala flood victims in August 2018. He is also actively involved in ensuring the social, economic and religious welfare of expatriate Indians in the Persian Gulf region. He played a major role in finding land for the Christian community in the region to build churches, and secure cremation grounds for the Hindu populace in the Gulf region. M. A. Yusuff Ali also extended help to Indians during the amnesty period in the Persian Gulf when hundreds of Indians lost their livelihood. He helped rehabilitate people who lost their livelihood in the Calicut market fire as well. Yusuff Ali has pledged to donate of Rs 50 million (Dh2.5 million) for the flood-hit south Indian state of Kerala in the event of the 2019 Kerala floods.