Klaveno was cast in HBO's "True Blood" in the role of Lorena, the vampire "maker" of the main character Bill Compton. She first appeared in the fifth episode of season one and became a regular with starring credits in the second half of season two. Klaveno was nominated with the starring cast for the "Outstanding Performance by an Ensemble in a Drama Series" at the 16th Screen Actors Guild Awards in January 2010. She and her costar Stephen Moyer were awarded the "Holy Shit Scene of the Year" award at the Spike 2010 Scream Awards for their scene in season three where Bill turns Lorena's head around 180 degrees while having sex.