In May 2019, Chukwueze was invited to represent Nigeria's senior team at the Africa Cup of Nations and the Under-20 team at the Under-20 World Cup. However, Villarreal said he could only play in one of the tournaments. He ultimately decided to take part with Nigerian's senior squad for Africa Cup of Nations hosted in Egypt and scored his first senior goal in Nigeria's 2–1 win over South Africa in the quarter finals.