Perišić made his debut for the Croatia national team in 2011, and represented his nation at Euro 2012, 2016 and 2020, as well as the 2014 and 2018 World Cup, reaching the final of the latter. Instrumental to Croatia's second "golden generation", Perišić is the nation's player with most goal contributions at the major tournaments (14), and the first Croatian player ever to score in a World Cup final.