From 2006 to 2008 she covered Senator Barack Obama's campaign for President of the United States, and was the only independent journalist to follow him from the run up to his announcing his candidacy through his victory on election night. Tufankjian took more than 12,000 photographs throughout the campaign. She released a book featuring a selection of the photographs titled "Yes We Can: Barack Obama's History-Making Presidential Campaign" in December 2008, which sold out its initial 55,000 copy run a month before it was released.