Combi was born in Turin on 20 November 1902 and played for Juventus' youth side; he debuted in the Italian Serie A on 5 February 1922 in a match against Milan. Combi spent his entire club career with Juventus F.C.; he played 351 games in Serie A, winning five titles – in 1926 (having conceded only 18 goals during the season), 1931, 1932, 1933 and 1934 as part of the first "golden age" of the club with a record of five championship victories in a row, a feat known as "Il Quinquennio d'Oro" (The Golden Quinquennium).