On 26 May 2015, Ambríz was confirmed as the new manager at Club América, signing a two-year contract. He led América to a disappointing run at the FIFA Club World Cup, losing the quarter-final match to Chinese team Guangzhou Evergrande, and defeating Congolese club TP Mazembe to claim a fifth place finish in the competition. The following year, Ambríz led América to the CONCACAF Champions League finals, defeating Tigres UANL 4–1 on aggregate, thus earning their qualification to the 2016 FIFA Club World Cup. In September, he was ranked as the 10th best coach according to "Football Coach World Ranking". On 17 September, after suffering a 2–0 home defeat to León, Ambríz was sacked as manager the following day.