Fenati started the 2016 season with a pole position at Qatar. However, he only managed 4th in the race. He finished in 20th in Argentina, before his first win of the season in the United States. He was seventh at Jerez, before a second-place finish at Le Mans, losing out to Brad Binder by 0.099 seconds. Fenati qualified on pole at Mugello, but failed to finish the race. He was fourth in both Catalunya and Netherlands, before a pointless 18 position in Germany. Fenati was dropped by Sky Racing VR46 in Austria as a disciplinary action for disagreeing with Uccio Salucci. On 16 August the VR46 team terminated their contract with Romano for the 2016 and 2017 seasons stating behavioural issues in conflict with team policy as the reason behind the split.