After the Great Schism the Orthodox Church promoted it to its own metropolitanate in early fourteenth century. By this time Tenedos was part of the but its location made it a key target of the Venetians, the Genoese and the Ottoman Empire. The weakened Byzantine Empire and wars between Genoa and Venice for trade routes made Tenedos a key strategic location. Although in 1304, Andrea Morisco, a Genoese adventurer, backed by a title from the Byzantine emperor Andronikos III, took over Tenedos and later, sensing political tension in the Byzantine empire just before the Second Byzantine Civil War, the Venetians offered 20,000 ducats in 1350 to John V Palaiologos for control of Tenedos, no Latin bishopric was established.