On 13 September 2015, Insigne opened the 2015–16 Serie A season by scoring in a 2–2 draw against Empoli. On 20 September, he scored again in a 5–0 win over Lazio, also setting up Allan's goal. On 26 September, Insigne made his 100th Serie A appearance with Napoli and scored his third goal of the season in a 2–1 home win over defending Serie A champions Juventus, although he was also later forced off the pitch after sustaining an injury during the match; the club, however, later reported the injury was not serious. He continued his goalscoring run in the following match, scoring twice and setting up Allan's goal in a 4–0 away win over Milan, bringing his seasonal tally to five goals in seven games. Insigne's prolific performances even led to comparisons with former Napoli legend Diego Maradona, which Insigne played down.