On the final lap of the 2010 Indianapolis 500, Conway was battling side by side with Ryan Hunter-Reay when the two cars became entangled as Hunter-Reay's Dallara ran low on fuel and stuttered between turns 3 and 4, resulting in Conway's Dallara-Honda being launched into the air. Conway suffered a broken leg during the crash and was flown straight to the Methodist Hospital of Indianapolis. Conway also received a compression fracture of one of his thoracic vertebrae and has been fitted with back brace. The injuries effectively ended his participation in the rest of the 2010 Izod IndyCar Series season.