Falcao missed the first La Liga match of 2013 due to muscle fatigue, but returned in the second match against Real Zaragoza on 13 January, where he scored a penalty in a 2-0 victory. In the first leg of the Copa del Rey quarter-finals against Betis, Falcao scored a header in a 2–0 victory on 18 January. He suffered an muscle injury in a match on 20 January, causing him to miss 3 games, including the second leg of the Copa del Rey quarter final against Betis and the first leg of the semi finals against Sevilla. Falcao returned for the second leg to score against Sevilla in a 2–2 draw, helping Atlético advance to the finals with a 4–3 aggregate scoreline. Falcao scored a double against Granada in a comfortable 5–0 victory on 14 April. The second goal marked Falcao's 200th career goal (counting both club and nation). A week later, Falcao scored the only goal in a 0–1 away victory against Sevilla at the Ramón Sánchez Pizjuán Stadium.