Udhruh was inhabited by the Nabateans as early as the 1st century BCE and later became the site of a fortified Roman military camp used as the headquarters of Legio VI Ferrata. Udhruh continued to thrive and by the 6th century was one of the most prosperous towns in Palaestina Tertia. It submitted to the Islamic prophet Muhammad in 631. It later became the site of two decisive conferences in 658 and 661 that respectively arbitrated the end of the First Muslim Civil War and the onset Muawiyah I’s caliphate. As late as the 9th century it was the regional center of the Sharat district. During the Ottoman era a fort was built in the town. Udhruh was abandoned during this era and the modern settlement was founded in the late 1930s.