Born in Cesenatico, Ghezzi started his career at Rimini in 1947 and later played for Modena between 1949 and 1951. He subsequently joined Internazionale in 1951, making his Serie A debut that season in a 3–1 home win over Legnano on 21 October. He remained at the club for 7 years, playing a total of 191 matches with the team across all competitions (Serie A, European Cup and Coppa Italia). During his time with Inter, he won 2 Serie A titles in 1953 and 1954.