On 30 August 2010 Daprelà joined Brescia for an undisclosed fee signing a five-year contract and joining up with Swiss teammate Gaetano Berardi. On 26 September 2011, Daprelà made his debut for Brescia in a 2–1 loss against A.S. Bari. In his first season at Brescia, Daprelà made ten appearance (coming on as substitute five times) but his team played poorly and were relegated to Serie B after just one season in Serie A. Following Brescia's relegation Daprelà stayed, while some of the club's key players left. His first season at Brescia was mixed for Daprelà.