Murray was named in Ireland's training squad for the 2013 Six Nations Championship on 17 January 2013. He started at scrum-half for Ireland's opening 30–22 win against Wales on 2 February 2013, their 12–6 defeat to England on 10 February 2013, and the 12–8 loss to Scotland. He put in an outstanding performance to win the Man-of-the Match award in Ireland's 13–13 draw with France. He started in Ireland's final game of the tournament, a 22–15 loss to Italy, on 16 March 2013.