On 9 February 2016, it was confirmed that Chiellini would miss the Serie A match on 13 February against Napoli, as well as the first round of 16 leg of the Champions League on 23 February against Bayern Munich due to an injury. Chiellini returned to action on 28 February to take on rivals Internazionale, yet again sustaining an injury to his thigh which caused him to limp off the pitch and substituted off in the 35th minute. After already having missed the first round of 16 leg against Bayern, there was further doubt as to if he would miss the second leg as well on 16 March. However, after medical testing it was estimated he would only be out for ten days, initially thought to only miss the second leg of the Coppa Italia semi-finals against Internazionale on 2 March and a Serie A match against Atalanta on 6 March; he wouldn't be fit for the second round of 16 leg of the Champions League, and missed the match. He returned from injury on 2 April, starting in a 1–0 home win over Empoli, but sustained yet another injury to his adductor longus muscle in his right thigh before being substituted off in the 54th minute of that match; further tests in the following days revealed he would be out for 20 days. He returned to action once again in a 2–1 away defeat to Verona, on 8 May. After constant injury spells throughout the season, Chiellini scored in the last match of the season on 14 May in the 77th minute of a 5–0 home win over Sampdoria, as Juventus celebrated winning the league title for a fifth consecutive time since the 2011–12 season; this was Chiellini's 400th appearance for Juventus. On 21 May, Chiellini captained Juventus in the 2016 Coppa Italia Final in Rome; he played a key role in a 1–0 extra-time victory over Milan (the club's eleventh Coppa Italia title in total), helping his team to defend the title and keep a clean sheet. He later lifted the trophy as Juventus became the first Italian club ever to win consecutive domestic doubles.