After departing Malta on 3 November, the boat was assigned to patrol north of Sicily, Italy, to support the Allied landings in North Africa. On the way to her patrol area, "Safari" was attacked by German Messerschmitt Bf 109 fighter aircraft, but was not damaged. She sank the Italian vessel "Bice" on 13 November, east of Sousse, Tunisia. After changing her patrol area to the Gulf of Sirte three days later, she torpedoed and sank the German transport "Hans Arp", anchored along with a German minesweeper, off Ras Ali, Libya. "Safari" launched a torpedo at several barges anchored at Ras Ali on 17 November, but their draught was too shallow and the torpedo passed under and hit the port's mole, destroying it along a distance of , killing five and wounding fifteen men. "Safari" also attacked an unidentified schooner with a torpedo later in the day, but missed. On 18 November, the boat sank a small vessel and damaged a landing barge with gunfire in the same area. She fired a torpedo on 21 November at a landing barge in Ras Ali, but the torpedo again went under and hit the mole as it had four days prior. On 22 November, she damaged another landing craft off of Ras Sulta with gunfire, but had to break off the attack after expending all her 3-inch ammunition. The boat returned to Malta on 24 November.