Her next major deployment was in July 1943, when she took part in the invasion of Sicily. She was one of 18 British, Greek and Polish destroyers which, along with four Royal Navy cruisers, made up the escort for the battleships , , and , the aircraft carriers and in the Ionian Sea. "Inglefield"s main role was to search for U-boats and to bombard enemy positions ashore. Throughout the operations on Sicily, she was based at Malta. When the invasion of Italy took place, "Inglefield" supported the landings at Salerno in a similar way. After the beachhead was established, she formed the escort back to home waters, but was soon sent back to the Mediterranean Sea for operations in Italy. One task was to escort , with British Prime Minister Winston Churchill on board, from Algiers to Alexandria.