I-380 crosses two of Iowa's major rivers, the Iowa and the Cedar. Both rivers have affected the interstate during major floods, as the case was in 1993 and in 2008. During the Great Flood of 1993, I-380 and Iowa 965 were both closed at the Iowa River's Coralville Lake reservoir between July 13 and July 28. The roads reopened after the lake's waters receded enough to allow Department of Transportation inspectors to check the three bridges over the water.