The 2016 United States Olympic Trials saw Schmitt finishing fourth at the 200m (1:56.72), qualifying her to the relay team. Schmitt became the ninth American female swimmer to appear in three Olympics, and only she and Elizabeth Beisel were members of each team since 2008. She was named one of the captains of the U.S. Olympic Swim Team, alongside Phelps, Beisel, Nathan Adrian, Anthony Ervin, and Cammile Adams. Schmitt earned her seventh Olympic medal by taking part in the qualifying heat of the 4 × 100 m freestyle relay, and during the finals the U.S. team won the silver. Schmitt earned her fourth gold medal, and eighth Olympic medal, by swimming in the finals of the 4 × 200 m freestyle relay with Leah Smith, Maya DiRado, and Katie Ledecky.