Panis had the potential for a big season in while driving for Alain Prost, who had purchased Ligier. On Bridgestone tyres, he took the tyre company's first podium at Brazil. He was running second in Argentina before retirement. After 6 races, he stood third in the championship thanks to another podium finish with second place in Spain. A win could have been possible in that race had he not been held up lapping backmarkers for seven laps, losing him a total of 6 seconds to leader Jacques Villeneuve. At the 1997 Canadian Grand Prix, he broke both legs in a high-speed accident, causing him to miss the next seven races of the season. His place in the team was taken by Jarno Trulli, until he returned for the final three races of the season. He achieved sixth place at Luxembourg and appeared to show that he had fully recovered from his accident, as he drove as well as he had done before the crash. Despite missing half of the year, he still managed 9th in the championship with 16 points.