Mokarzel was a vehement opponent of the Great Syrian Revolt of 1925 which pitted Syrian and Lebanese rebels against the French Mandatory authorities. Mokarzel formed the "Committee to help the Lebanese victims and the refugees" and initiated a fundraising campaign supervised by the Lebanon League of Progress for the benefit of Lebanese victims of the uprising from Rashaya, Hasbaya and Marjayoun. He managed to collect more than half a million dollars that were transferred to a committee in Lebanon headed by Moussa Nammour, a member of the Lebanese parliament. "Meraat-ul-Gharb" (The Mirror of the Occident), a rival newspaper, accused Nammour of socializing with the French and accused Nammour's organization of corruption. Mokarzel was opposed to Emir Shakib Arslan, a leading figure of the Druze revolt, with whom he had fundamental political disagreements. He called on his readers to petition the US government to ask for the deportation of Arslan and of his delegation. Mokarzel managed to get the delegation under surveillance.