Berardi opened the 2015–16 Serie A season with a Man of the Match performance in a 2–1 home win over Napoli, setting up Floro Flores's goal; however, he also picked up an injury during the match, which would reportedly rule him out for a month and a half. He returned to the pitch after an early recovery on 20 September 2015, coming on as a substitute in a 2–2 away draw against Roma. He scored his first goal of the season from the penalty spot in a 2–1 home win over Lazio on 18 October 2015. Sassuolo finished the league season in sixth place, sealing a spot in the third qualifying round of the 2016–17 UEFA Europa League.