In 1959, Dupre played in only the first 4 regular games of the season. His only touchdown was a 2-yard pass from John Unitas against the Chicago Bears on October 18. He sustained a season-ending injury while driving home from a Tuesday practice. He put on the brakes and felt something pop in his leg, that caused ruptured blood vessels in his thigh. Dupre was a member of the 1959 Baltimore Colts championship team, but due to his injury, he did not play in the rematch against the Giants, which the Colts won 31-16. Halfback Mike Sommer substituted for Dupre in the 1959 NFL Championship Game.