Muffat qualified to enter three events at the 2012 Summer Olympics in London. She won the gold medal in the 400 m freestyle with a new Olympic record, as well as the silver medal in the 200 m freestyle event. Also, her 4 × 200 m freestyle team won the bronze medal in a time of 7:47.49. [Camille Muffat (1:55.51); Charlotte Bonnet (1:57.78); Ophélie-Cyrielle Étienne (1:58.05); Coralie Balmy (1:56.15)]. She thus equalled Laure Manaudou's 2004 Olympics achievement of one gold, one silver and one bronze, and also became only the third Frenchwoman after Micheline Ostermeyer and Manaudou to win three medals in a single summer or winter Olympic Games.