For the next two-and-a-half years, the 13th Brigade took part in the fighting in the trenches along the Western Front in France and Belgium and was engaged in a number of significant actions. Its first major action came at Mouquet Farm in August 1916, which was followed by further actions at Messines and Passchendaele during 1917, and around Dernancourt, on the River Ancre, where the brigade fought a defensive action in early 1918. But, the brigade's most notable action came during the Allied attack on Villers-Bretonneux on 25 April 1918, during the Second Battle of the Somme that took place amidst the German Spring Offensive in early 1918. The brigade's casualties during the offensive were heavy, and as a result one of its battalions – the 52nd – was broken up and its personnel used to reinforce the other three battalions in mid-May 1918. After the German offensive was blunted, the remaining three battalions of the brigade undertook further actions as the Allies went on the offensive, launching their Hundred Days Offensive around Amiens in August. They continued operations into late September, attacking the Hindenburg Line. Early the following month, the majority of the Australian Corps brigade was withdrawn from the line for rest.