Natalino was included into the first team during the 2010–11 Serie A season due to an injury crisis. Natalino then made his competitive debut for the first team on 28 November 2010, aged 18 years and 8 months, coming on for Davide Santon in the half-time break of a home league match against Parma, then ended in a 5–2 win for Inter. Natalino was successively featured in the starting line-up by head coach Rafael Benítez in the next match against Lazio, that ended in a 3–1 defeat for the "Nerazzurri".