The regiment was part of the amphibious expedition to the Caribbean and participated in the disastrous British defeat at the Battle of Cartagena de Indias in March 1741 during the War of Jenkins' Ear. The regiment was ranked as 24th in the British Army order of precedence in 1747 and became the 24th Regiment of Foot in 1751. It took part in the Siege of Fort St Philip in Menorca in April 1756 during the Seven Years' War. It was also part of the amphibious expedition against, or descent on, the coast of France and participated in the disastrous British defeat at the Battle of Saint Cast in September 1758.