On 20 August, Higuaín scored the winning goal on his Juventus debut in their opening match against Fiorentina of a 2–1 home win. On 10 September, he scored a brace in a 3–1 home win over Sassuolo. On 29 October, he scored the winning goal against his former team, Napoli, but did not celebrate his goal, in a 2–1 home win. On 5 April 2017, Higuaín scored twice against Napoli in the 2016–17 Coppa Italia second semi-final leg to put Juventus through to the final 5–4 on aggregate, in spite of a 3–2 away loss. The following week, he became the first player to score more than 20 goals in his debut season for Juventus since John Charles and Omar Sívori had managed the same feat during the 1957–58 Serie A season, when he scored a brace against Chievo. On 15 April, Higuaín scored both goals in a 2–0 away win against Pescara, which included his 200th league goal in Europe. On 3 June, Higuaín started in the Champions League Final, but Juventus were defeated 4–1 by defending champions Real Madrid; he set up Mario Mandžukić's temporary equaliser in the first half.