Khuzayma ibn Khazim ibn Khuzayma al-Tamimi () (died 818/9) was a powerful grandee in the early Abbasid Caliphate. The son of the distinguished military leader Khazim ibn Khuzayma, he inherited a position of privilege and power, and served early on in high state offices. He was crucial in securing the accession of Harun al-Rashid in 786, and was an influential figure throughout his reign. During the civil war of 811–813 he sided with al-Amin, but finally defected to the camp of al-Amin's brother al-Ma'mun and played a decisive role in ending the year-long siege of Baghdad in a victory for al-Ma'mun's forces.