Soon after its formation, the Euphrates Liberation Brigade fought the Islamic State of Iraq and the Levant (ISIL) west of Manbij during the Battle of al-Bab, in course of which it was allegedly bombed by the Turkish Air Force on 20 November. In April 2017, elements of the Euphrates Liberation Brigade were among a contingent of 200 MMC fighters that were sent to al-Thawrah in order to help the SDF to capture the city from ISIL. Under the command of Ibrahim Semho, the militia also took part in the following battle for ISIL's self-proclaimed capital Raqqa. Other parts of the unit remained at the frontlines west of Manbij, where at least one of their fighters was captured by Turkish-backed rebels in May 2017.