Although the press initially reported that Fisher would compete in the 2010 Honda Grand Prix of St. Petersburg for the first time since 2007, she chose to forgo the race and the following Indy Grand Prix of Alabama at Barber Motorsports Park and replace herself with fellow American driver Graham Rahal, persuading her primary sponsor that Rahal was ideal for her team. The two-race agreement reduced Fisher's 2010 schedule from nine to seven rounds. Thus, her first race of 2010 was at Kansas, where she finished 17th after a season-best qualifying start of 14th. At the Indianapolis 500, Fisher had a career-worst start of 29th; she finished the race 26th after she was collected in a lap 124 multi-car crash. Fisher's best result of the season was a 15th-place, which she achieved in Texas as well as in Chicagoland. She ended the season with a 22nd-place finish at Homestead-Miami Speedway. Fisher was 26th in the drivers' standings with 92 points. She looked for a full-time driver to replace her because she thought her driving was taking away from her ability to adequately run the team. Fisher left open that she would still run a part-time schedule the next season. In November, however, she announced her retirement from racing, and driver Ed Carpenter replaced her in the No. 67 car for the 2011 season.