On 3 July 2019, Ocampos signed a five-year contract with La Liga side Sevilla for an undisclosed fee. On 11 August 2020, he scored the winning goal for Sevilla in the 88th minute, in a 1–0 win against Wolverhampton Wanderers in the 2019–20 UEFA Europa League quarter-finals. In his debut season with Sevilla, Ocampos scored 14 goals in La Liga to finish 4th in the table, and eventually won the Europa League. On 24 September 2020, he scored from a penalty in 1–2 defeat against Bayern Munich in the 2020 UEFA Super Cup.