Subsequently, Liuzzi was announced that he would be testing for Hispania Racing at Circuit de Catalunya, as the Spanish team evaluated him for their second race seat alongside Narain Karthikeyan. Liuzzi was confirmed in this role on 9 March 2011. He did not qualify for the and retired in Malaysia after the team withdrew him for safety reasons. He recorded his first finishes with the team with a pair of 22nd-place finishes in China and Turkey but retired in Spain with a gearbox issue. He took a 16th-place finish in Monaco, and a 13th place in Canada, Hispania's best finish to date. After a 23rd-place finish at Valencia and an 18th at the , he failed to finish in Germany with electrical problems. Liuzzi finished as the final classified finisher in Hungary (20th), and Belgium (19th), before a first-lap retirement in Italy after contact with Heikki Kovalainen. As a result of the contact, Liuzzi slid across the grass and directly into Vitaly Petrov and Nico Rosberg. He finished as the final classified finisher in Singapore (20th), Japan (23rd) and Korea (21st).