At international level, Mané has registered 24 goals in 76 appearances for Senegal since his debut in 2012, and currently ranks as his nation's third all-time top goalscorer, and fifth all-time for appearances. He represented Senegal at the 2012 Olympics, as well as the 2015 and 2017 editions of the Africa Cup of Nations. In the 2019 iteration, Mané helped Senegal to a runners-up finish, and a year later, was named African Footballer of the Year. Mané also represented his nation at the 2018 FIFA World Cup, in their second ever appearance in the competition. Mané was cited as one of the Top 100 most influential Africans by "New African" magazine in 2020.