The main event was Raw's women's Elimination Chamber match between Natalya, Liv Morgan, Asuka, Ruby Riott, Sarah Logan, and NXT's Shayna Baszler in which the winner earned a Raw Women's Championship match against Becky Lynch at WrestleMania 36. Natalya and Riott started the match, followed by Logan as the third entrant. Baszler entered fourth and dominated her opponents, eliminating Logan, Riott, and Natalya each with the "Kirifuda Clutch" submission. As Morgan entered fifth, Baszler slammed her against the cage and the chamber pod, after which, Baszler also eliminated Morgan with the "Kirifuda Clutch" while taunting Asuka, who entered last. After Baszler and Asuka went back-and-forth in an attempt to apply their respective submission holds, Baszler applied the "Kirifuda Clutch" on Asuka, who passed out, thus eliminating Asuka to win the match and earning the Raw Women's Championship match against Lynch at WrestleMania. With this win, Baszler became the first Elimination Chamber match winner to single-handedly eliminate all other opponents, as well as tie the record for most eliminations in a single match at five (previously set by Braun Strowman in the 7-man Elimination Chamber match at the 2018 event).