John Aisance (Ojibwe name Aisance) was a chief among the Chippewas of Lakes Huron and Simcoe and leader of the Otter clan of that people from at least 1815 until his death in 1847. He participated in the Lake Simcoe–Lake Huron Purchase in 1815, served the provincial government during the Upper Canada Rebellion, and was the first and founding chief of the Beausoleil First Nation.