In 2001, Wagner took office as a co-chair of the Republican National Committee and helped preside over the 2004 Republican National Convention. In this position, she took a strong role in directing the development of the Winning Women initiative, whose aim was to improve the GOP's image with women and demonstrate the relevance of its platform to them. Her work with the committee took her to 48 states. In January 2005, she left her role as co-chair after one term.