As a result, Floccari sealed a loan move to struggling Lazio, for €500,000. He made his debut after just one training session and scored twice in a 4–1 win over Livorno. Following that, Floccari made a surprising impact on the team, and was one of the key players in guiding the club to 12th in the league, well clear of the relegation zone. He missed a vital penalty in the defeat against Roma in the vital derby, but made up for it by scoring the winner against former club Genoa seven days later, a result that all but granted Lazio's Serie A status for 2010–11. At the end of season Lazio signed him permanently for a €8.5 million transfer fee having agreed a four-year contract.