After living in Munich (Germany) and in Basel (Switzerland), he took refuge in Liège (Belgium) with his wife and several other conventional regicides, including the former president of the Convention and deputy of Marne Thuriot de la Rozière, and the deputies of Ille-et-Vilaine , of Lot-et-Garonne , of Haute-Garonne Mailhe, of Indre-et-Loire Ysabeau and of Oise Matthieu-Miranpal. He was helped for his settlement in the Belgian city by a certain police commissioner Wassin, who at first took him for his younger brother (the Colonel of Napoleon's Grande Armée, Jean-Chrysostôme Calès) with whom he had served. There, to survive, he continued practicing medicine, as well as other activities, such as works on the agricultural economy, as he mentioned himself in a revelatory letter addressed to one of his nephews Godefroy Calès (and to his five-year-old grand-nephew, Jean Jules Godefroy Calès, both future Republican representatives in 1848 and 1885), which gives an interesting piece of information about his new life in the Belgian city. He also demonstrates in this letter that, until the twilight of his life, he kept a constant execration of the nobility: « "These nobles have no nobility and, as long as this caste will exist, it will be the misfortune of France. I do not wish it to be annihilated, but I would have it put into the inability to harm." »Shortly after his arrival at Liège, the Bourbons, answering to the solicitations of a friend to whom Calès had saved the life during the Terror, consented to let him return to France, but Calès refused, alleging that being exiled by a law, he could only come back by a law. After the Revolution of July 1830, he did not wish to take advantage of the abrogation of the amnesty law promulgated by the Monarchy of July, and thus he never returned to France.