On 12 July 2015, Immobile joined Sevilla on a season-long loan after scoring just three goals in the league in his first season at Borussia Dortmund, with a total 10 goals in 34 matches across all competitions. Sevilla also had an option to sign him outright. He made his debut for the club on 11 August 2015, coming off the bench to replace Kevin Gameiro in the 80th minute of the 2015 UEFA Super Cup final, against Barcelona, and assisting Yevhen Konoplyanka's temporary equaliser to send the match into extra-time; Barcelona went on to win the match 5–4.