Di Stéfano made his international debut on 4 December 1947, in a match against Bolivia at the Estadio George Capwell in Ecuador, during the 1947 South American Championship. He scored his first international goal in that same match, helping Argentina to a 7–0 win. Di Stéfano scored five more goals during the championship - including his first hat-trick against Colombia - as Argentina successfully defended the title they had won the previous year on home soil.