"Manitowoc" conducted two deployments off Vietnam in 1971 and 1972 during the Vietnam War. She carried troops to Lebanon in 1982 and 1983 during the U.S. participation in the Beirut Multinational Peacekeeping Force. En route to Lebanon in October 1983 she also participated in Operation Urgent Fury, the invasion of Grenada as part of Amphibious Squadron Four. On 25 October "Manitowoc" and , a , were unexpectedly ordered to transit to the western shore of the island to open a second front on the enemy forces. A beachhead at Grand Mal Bay near the capital city was secured by 13 amphibious landing craft carrying a company of marines which were launched from the LST. "Manitowoc" participated in the Gulf War before decommissioning on 30 June 1993.