At the end of the calendar year, Konoplyanka was one of the shortlisted nominees for UEFA Team of the Year. He was an unused substitute in the 2016 UEFA Europa League Final, where Sevilla beat Liverpool 3–1 in Basel to claim their fifth trophy. He played seven matches in their Copa del Rey campaign, scoring a late equaliser as a substitute in a 2–2 draw at Celta Vigo in the semi-finals (6–2 aggregate), and also came off the bench in the final where they lost 2–0 to Barcelona after extra time. On 9 August, he scored a penalty in the 2016 UEFA Super Cup against Real Madrid, an eventual 3–2 loss following extra time in Trondheim.