The 159th Infantry Brigade was an infantry brigade of the British Army. Part of the Territorial Army (TA), the brigade was assigned to the 53rd (Welsh) Infantry Division and served with the division in the early stages of the Second World War until May 1942 when it was transferred to be the motorised infantry element of the 11th Armoured Division. The brigade would serve with the 11th Armoured in North-west Europe from June 1944 to May 1945.