Wüst started the season with two titles and one second place at the 2007 Dutch Distance Championships. She also won the 2007 Dutch Allround Championships. At the 2007 European Championships Wüst led the championships after 3 of 4 distances but was beaten by Martina Sáblíková. The next weekend she competed in the 2007 World Sprint Speed Skating Championships in Hamar, again winning the silver medal. She became World Allround Champion during the 2007 World Allround Championships for the home crowd in Heerenveen. She won the 2006–07 World Cup in the 1500m after winning two of the six races, as well as the 1000m during the World Cup Final in Calgary. At the 2007 World Distance Championships she won a gold medal in the 1000m, breaking the national record, and another in the 1500m. With Renate Groenewold and Paulien van Deutekom she won silver in the team pursuit behind Canada.