On July 27, 2012, Scutaro was traded, along with cash considerations, to the San Francisco Giants for infielder Charlie Culberson. In a game against the St. Louis Cardinals at Busch Stadium on August 8, 2012, Scutaro drove in a career high seven runs including a grand slam. He hit .306 for the regular season, including .362 as a Giant, helping the Giants win the National League West title. He was awarded the NLCS MVP after tying the NLCS record with 14 hits and also batting .500 (14 for 28) with six runs scored and four runs batted in during the seven game series against the Cardinals. On October 28, in the tenth inning of Game 4 of the 2012 World Series, Scutaro drove in Ryan Theriot for the winning run, as the Giants swept the Detroit Tigers.