In the Second World War "City of Venice" carried troops and supplies between the UK, Africa, India and Egypt. In 1941 she paid one visit to Halifax, Nova Scotia, from where she sailed to Liverpool in Convoy HX 146. She sailed mostly unescorted, with only occasional convoy protection. After the Allied invasion of French North Africa she sailed between the Clyde and the Mediterranean, starting with Convoy KMS 3G that left the Clyde on 8 November and reached Philippeville in French Algeria on 26 November.