On 17 January 2021, Koeman managed Barcelona for the first time in a cup final, with his side losing 3–2 to Athletic Bilbao after extra time in the final of the 2020–21 Supercopa de España at the Estadio La Cartuja in Seville. On 7 February, Koeman led Barcelona to their sixth consecutive away win in La Liga after winning 3–2 against Real Betis, equalling Luis Enrique's feat achieved in the 2015–16 season. On 11 March, Barcelona were knocked out of the Champions League in the round of 16 against PSG after failing to turn around a 1–4 loss at home, losing 2–5 on aggregate. On 10 April, Barcelona's 19 game unbeaten run in La Liga came to an end after falling to Real Madrid 2–1 away from home in the second "El Clásico" of the season. On 17 April, Koeman led "Barça" to a 4–0 win over Athletic Bilbao the 2021 Copa del Rey Final, gaining revenge for the Supercopa defeat at the same venue three months earlier. On 29 April, Barcelona were presented with a golden opportunity to go top of La Liga but failed to capitalize after losing out to Granada away 2–1 despite taking the lead. Barcelona's title charge ended with a disappointment after winning only two of their last five matches and eventually finished third in the league table. On 3 June, club president Joan Laporta confirmed that Koeman would be staying in charge for another season.