São Tomé and Príncipe competed at the 2016 Summer Paralympics in Rio de Janeiro, Brazil from 7 to 18 September 2016. The country's participation in Rio marked its debut appearance in the quadrennial event, although it had competed in the Summer Olympics six times since the 1996 Games. The delegation consisted of a single short-distance runner Alex Anjos, who was chosen as São Tomé and Príncipe's flag bearer for the opening ceremony. Anjos was disqualified from the men's 100 metres (T47) for arriving late and failed to advance into the final of the men's 400 metres (T47) after failing to set a fast enough lap time.