Following the army reforms of 1751, the regiment was retitled 4th (King's Own) Regiment of Foot. At the start of the Seven Years' War in 1756, it was part of the Menorca garrison; forced to surrender in June it was transported to Gibraltar. It spent the rest of the war in the West Indies, taking part in the capture of Guadeloupe, Martinique and Saint Lucia before returning home in July 1764.