Weis served as the first vice president of the newly founded National Federation of Republican Women and served as its president in 1941. She was a delegate at large to the 1940, 1944, 1948, 1952 and 1956 Republican National Conventions. In 1948 Weis seconded the nomination of Thomas E. Dewey for president, the first woman to do so. She went on to work as associate campaign manager for the Republican Party in the 1948 election.