During the War of the Second Coalition, Hohenzollern again served in Italy. He commanded a brigade under Pál Kray in a battle at Legnago on 26 March 1799. He fought at the Battle of Magnano where he temporarily commanded a division. He besieged the Milan citadel starting on 30 April and received its surrender on 24 May. On 12 June, with 4,300 soldiers, he attempted to block Jacques MacDonald's much larger French force at the Battle of Modena but was defeated with heavy losses. He also fought at the battles of Trebbia and Novi. He won promotion to Feldmarschal-Leutnant in October 1799.