Gyan is the all-time leading goalscorer of the Ghana national team, with 51 goals. He represented Ghana at the 2006, 2010 and 2014 FIFA World Cups. With 6 goals, he is the top African goalscorer in the history of the World Cup. Gyan has also represented Ghana at the 2004 Summer Olympics and in seven Africa Cup of Nations in 2008, 2010, 2012, 2013, 2015, 2017 and 2019, helping them finish in third-place in 2008 and runner-up in 2010 and 2015.