After studying with Berteau, Jean-Pierre Duport made his debut at the age of 19 at the Concert Spirituel, then the center for non-operatic music in Paris. Between 1766 and 1769 Duport was employed by the Prince of Conti, after which he spent two years in England and two years in Spain. In 1773, Frederick the Great the King of Prussia offered Duport a position as principal cellist of his orchestra, and Duport accepted and remained in Berlin for the rest of his life. Duport was the cello tutor of Frederick's nephew, Prince Friedrich Wilhelm II, and soon after Friedrich Wilhelm II was crowned king in 1786, Duport was placed in charge of all chamber music at the court. In 1790, Duport's younger brother Jean-Louis Duport joined him in Berlin, fleeing the French Revolution. Between the two of them, and the patronage of Friedrich Wilhelm II, Berlin became a "magnet for new compositions for the cello" until Napoleon defeated Prussia and captured Berlin in 1806. At this point the younger brother returned to Paris, while the elder Duport remained in Berlin until his death in 1818.