Vukovich was killed in a chain-reaction crash while holding a 17-second lead on the 57th lap of the 1955 Indianapolis 500. He was exiting the second turn, trailing three slower cars—driven by Rodger Ward, Al Keller, and Johnny Boyd—when Ward's car hit the backstretch outer wall and flipped, resting in the middle of the track as a result of a broken axle. Keller, swerving into the infield to avoid Ward, lost control and slid back onto the track, striking Boyd's car and pushing it into Vukovich's path. After his car went over the outside wall and become airborne, it cartwheeled through the air multiple times landing on top of a group of parked cars before coming to rest upside down and bursting into flames. The cockpit side of his car struck a low bridge near Turn 2 when it was airborne. Boyd's car also flipped over and landed upside down as well. As the car burned, Ed Elisian stopped his undamaged car and raced towards Vukovich in an attempt to save him. It did not matter; Vukovich had perished instantly. He had been partially decapitated upon his car's impact with the low bridge. Two spectators were also injured when Vukovich's car landed on their Jeep.