Alessandro was unveiled at Brescia on 25 August 2010 and chose to continue wearing the number 32 shirt. Due to his popularity, ability and playing style, comparisons were drawn between Diamanti and former club icon Roberto Baggio, which Diamanti played down, however. In his debut season at Brescia, Diamanti scored six Serie A goals, behind only Andrea Caracciolo as the club's top scorer for the domestic season. Diamanti's sixth goal came in a 2–1 loss against Catania which confirmed Brescia's relegation to Serie B, just one season after promotion to the top-flight.