The activity of the D’Antona ranged in all fields of surgery. He also dealt with orthopedics and traumatology. His observations on the victims of the 1908 Messina earthquake allowed him to highlight some particularities of the injuries and to describe the crush syndrome. Again, he had extensive experience in gynecology; in many works he gave precise documentation of a large personal case series on the subject of hysterectomy and ovariectomy. He dealt with vascular surgery and thoracoplasty of thoracic fistulas. In the more strictly technical field, D’Antona is remembered above all for the introduction of the antiseptic method in the Neapolitan surgical school, which resulted in a sensational decrease in operative mortality. The antisepsis advocated by D’Antona then completed the improvement of the surgical techniques carried out by Gallozzi, making possible the great progress of the modern surgical clinic.