The following year, Aránguiz was once again a key player for Chile in their 2016 Copa América Centenario triumph. Aránguiz scored the crucial opening goal against Colombia in Chile's 2–0 semi-final victory over them. He then also played great in the final against Argentina and he converted a vital penalty in the penalty shoot-out which gave Chile victory once again against Argentina. Chile raised the Copa America trophy with this triumph and Aránguiz was a key player for them throughout the tournament.