In 2000, the squadron received the C-141C with an electronic "glass cockpit". In October 2000 after the USS "Cole" bombing in Yemen, seventeen members of the unit and the 183rd Aeromedical Evacuation Squadron deployed to Ramstein Air Base Germany. They picked up four injured sailors from Ramstein and flew them to Norfolk Naval Station, Virginia. In February 2003 the 183rd retired its last Starlifter in preparation for the arrival of the wing's first Boeing C-17 Globemaster III.