Wilson drove Dreyer &amp; Reinbold Racing's (DRR) No. 22 car in the 2010 season. A disagreement over the length of his contract with DCR, the departure of key team personnel and a desire for another experience led him to assess driving elsewhere. Wilson received a telephone call from Dreyer &amp; Reinbold co-owners Robbie Buhl and Dennis Reinbold and visited their workshop in January 2010. He was impressed by what he observed and signed to the team soon after. Wilson mentored his teammate Mike Conway on oval track racing and advised DRR on road courses. In the first four races he finished second at the Grand Prix of St. Petersburg and the Grand Prix of Long Beach. After qualifying 11th for the Indianapolis 500, Wilson led eleven laps and took seventh. Four races later, he took his first IndyCar pole position for the Honda Indy Toronto. The rest of Wilson's season saw him achieve a best of sixth at the Indy Grand Prix of Sonoma. He was 11th in the drivers' standings with 361 points.