Kalla took the first gold medal awarded at the 2018 Games in Pyeongchang when she won the skiathlon, breaking away from the leading group on the last lap of the course to take victory with a lead of 7.8 seconds over second-placed Marit Bjørgen. Her win made her the first Swedish woman to win three Winter Olympic golds, and tied her with canoer Agneta Andersson as the female Swede with most Olympic gold medals overall. It was also Kalla's sixth Olympic medal, equalling Anja Pärson's record for the most Winter Olympic medals among Swedish women. She then went on to win silver in the 10 km freestyle individual start, the 4 × 5 km relay (together with Anna Haag, Ebba Andersson and Stina Nilsson) and the team sprint (with Stina Nilsson).