In the subsequent summer, Ménez suffered back problems and underwent surgery in Monaco. On 21 August, he was ruled out for a month as further back complications arose. An infection meant he missed the first 26 games of the 2015–16 season and was kept from playing until his return in a 2–1 league win over Genoa on 14 February 2016. On 1 March, he started a match for the first time since April 2015, playing 76 minutes and scoring twice in a 5–0 Coppa Italia defeat of Alessandria, sending Milan to the final for the first time since 2003.