On 8 August 2017, Isco scored a goal in the 2017 UEFA Super Cup, contributing to Real Madrid's 2–1 victory against Manchester United. His performance earned him the man of the match award. In September 2017, he signed a new deal with Real Madrid until June 2022. During the 2017–18 UEFA Champions League, he made eleven appearances, when Madrid won their third consecutive and 13th overall Champions League title as they beat Liverpool 3–1 in Kyiv. He made 23 appearances during the league season, as Real Madrid won the 2019–20 La Liga.