Maxwell worked as a field organizer for the 2008 Obama presidential campaign, and was director of Progressive Media for the 2016 Hillary Clinton campaign. She is now director of Progressive Programming for SiriusXM, and hosts a weekly radio show on SiriusXM, "Signal Boost". In September 2017, Maxwell interviewed Hillary Clinton for a SiriusXM Progress Town Hall. In October 2020, Maxwell began hosting the daily news show "Zerlina" on Peacock TV.