Giles flew home from the 2006 Ashes tour of Australia on 1 December in order to care for his wife who had a brain tumour. He was not selected for England's 2007 World Cup squad, nor in their 2007 summer performance squad. On Warwickshire's pre-season tour he suffered some hip discomfort, which revealed a need for an operation. It kept him out for most of the 2007 English county series, and on 9 August, Giles officially announced his retirement from all forms of cricket, following advice from doctors in light of his injury.