In Game 4 of the 2016 National League Division Series against the San Francisco Giants with the Cubs having a 2–1 series lead, Zobrist drove in Kris Bryant to score the first run in the top of the ninth and later scored the tying run on a two-run single by Willson Contreras. The Cubs scored another run later that inning, sending them to the National League Championship Series. Following the Cubs' Game 7 victory in the 2016 World Series, after driving in the first of two go-ahead runs in the top of the 10th inning, he was named the World Series Most Valuable Player and received his second World Series ring.