In 2017, at WrestleMania 33, Lesnar defeated Goldberg to become the Universal Champion, on the same night where Reigns became the second person to defeat The Undertaker at WrestleMania. On the post-WrestleMania 33 episode of "Raw", Paul Heyman teased a match between Lesnar and Reigns for the Universal Championship since they were the only two men to have defeated The Undertaker at WrestleMania. Over the following year, Lesnar retained the Universal Championship in various matches, including a fatal four-way match at SummerSlam against Braun Strowman, Samoa Joe, and Reigns, who Lesnar pinned to retain. At Elimination Chamber in February 2018, Reigns defeated Strowman, Elias, John Cena, The Miz, Finn Bálor, and Rollins in the first-ever seven-man Elimination Chamber match to become the number one contender for the Universal Championship. In April, Lesnar had two successful, albeit controversial, televised title defenses against Reigns, first at WrestleMania 34 and then Greatest Royal Rumble inside a steel cage. Reigns eventually defeated Lesnar at SummerSlam in August, to win his first Universal Championship. On the October 22, 2018 episode of "Raw", however, Reigns relinquished the championship due to leukemia, a disease which he has been battling since 2007.