The 2010 season saw Patrick return to drive with the newly renamed Andretti Autosport in the IndyCar Series, as well as a limited schedule with JR Motorsports in the NASCAR Nationwide Series (now Xfinity Series). As in the previous year, her season began poorly as she could only muster a 15th-place finish at the inaugural São Paulo Indy 300 after spinning in inclement weather. Nevertheless, at the season's second round, the delayed Honda Grand Prix of St. Petersburg, Patrick made her first appearance in the top in seventh. At the Indianapolis 500, she qualified a career low 23rd; in the race, Patrick struggled with her car en route to finishing sixth. The Firestone 550 at Texas Motor Speedway one week later was her best performance of the season, which saw her lead one lap and finish in second. At the Indy Grand Prix of Sonoma, Patrick set a new series record for the most consecutive races running at the finish with her 29th event passing without her failing to finish. She ended her season by equaling her best result of the season in the final IndyCar race at Homestead-Miami Speedway which enabled her to finish tenth in the drivers' standings with 367 points.