The Ramadanids played a key role in 15th-century Ottoman-Mamluk relations, being a buffer state located in the Mamluk al-'Awasim frontier zone. In 1517, Selim I incorporated the beylik into the Ottoman Empire after his conquest of the Mamluk state. The beys of Ramadanids held the administration of the Ottoman sanjak of Adana in a hereditary manner until 1608.