At the 2008 Summer Olympics, Weber-Gale was as a member of the 4 × 100 m freestyle relay team in a final that has been heralded as the best relay in the history of swimming. He was the second leg of that relay and had a split of 47.02 as the US won the gold ahead of pre-race favorite France. Weber-Gale also earned a gold medal for his contribution in the heats of the 4 × 100 m medley relay. Weber-Gale also competed in both the 50 m and 100 m freestyle events but did not advance past the semifinals of either one.