On the October 2 episode of "Raw", Kalisto returned as the newest member of the cruiserweight division. As all other members of the division had broken WWE Cruiserweight Champion Enzo Amore's "no contact" clause and were not eligible to challenge him for the title, general manager Kurt Angle signed Kalisto to the division as Amore's next challenger. The following day, Kalisto defeated Ariya Daivari in his "205 Live" debut. On the October 9 episode "Raw", Kalisto defeated Amore in a main event lumberjack match to become the new Cruiserweight Champion. It was reported that Kalisto was a late replacement for Neville, who did not appear at the show. He lost the title back to Amore on October 22 at , failing to regain it in a rematch on November 19 at the Survivor Series kickoff show. Kalisto failed to regain the championship from Cedric Alexander at the Greatest Royal Rumble event on April 27, 2018.