In the mid-1930s, Mastibek married Margo Mamlezade, a Lezginka by nationality, with whom he had another son, Ulugbek. During the 1948 Ashgabat earthquake, Ulugbek died when a wall collapsed on him in front of Mastibek and Margo. Upon return to Tajikistan, She and Margo adopted two-year-old Akhmadbek, the son of Mastibek's younger brother, Davlatbek.