On 31 August 2010, Kaladze signed with Genoa; Milan later revealed that it was a free transfer. In the 2010–11 season, he played 26 matches and scored one goal, which came against Parma on 30 January 2011. He was named as second-best defender of the 2010–11 Serie A by "La Gazzetta dello Sport", being surpassed only by his former teammate, Milan's Thiago Silva. On 12 May 2012, Kaladze announced his retirement from football.