In a surprise decision by the Australian coaching staff, Targett was selected to swim the butterfly leg of the 4×100-metre medley relay in the heats. Targett swam a 51.30 and as a result was placed into the team for the final along with Hayden Stoeckel, Christian Sprenger and James Magnussen. Australia cinched bronze in the final, behind the US who claimed gold and only 0.32 of a second behind Japan.