Reina was also in Spain's squad for the 2013 Confederations Cup, in which they reached the final. His sole appearance in the tournament came in the second group game against Oceanian champions Tahiti, a 10–0 win at the Maracanã. With Spain's elimination already confirmed, he was selected to start in Spain's final group match of the 2014 World Cup keeping a clean sheet against Australia in a 3–0 win.