She was an early member of the executive of the Working People's Alliance (WPA) in Guyana, alongside Walter Rodney, among others, and served as Coordinator and Editor, International Secretary and Women's Secretary, until 2000. A founding member of the women's development organization Red Thread in Guyana in 1986, Andaiye was also an executive member of the Caribbean Association for Feminist Research and Action (CAFRA). She worked with the Women and Development Unit of the University of the West Indies (WAND) from 1987 to 1992, and from 1987 to 1996 with CARICOM, where she was a resource person preparatory to the 1995 World Conference on Women held in Beijing. Other groups with which she worked include the Global Women's Strike (GWS), the Women’s International Network for Wages for Caring Work, and Women Against Violence Everywhere (WAVE).