Hjorth-Hansen competed for the Danish swimming squad in the women's 200 m individual medley at the 2008 Summer Olympics in Beijing. Leading up to the Games, she cleared a FINA A-standard entry time of 2:12.74 at the Mare Nostrum Arena International Meet in Canet-en-Roussillon, France. Hjorth-Hansen dipped under the 2:12 barrier in the prelims to secure her spot for the semifinals, checking in with a Danish record and fifth fastest time of 2:11.99. Followed by the next morning's session, Hjorth-Hansen failed to advance to the final, as she finished her semifinal run with a tenth-place overall time in 2:12.26. Hjorth-Hansen also teamed up with Louise Mai Jansen, Micha Østergaard, and Lotte Friis in the 4 × 200 m freestyle relay. Swimming the lead-off leg, Hjorth-Hansen recorded a split of 1:59.16, and the Danish team finished the preliminary heats in tenth overall with a new national record of 8:00.81.