Panarin was not selected in the 2010 NHL Entry Draft and began his professional hockey career in the Kontinental Hockey League (KHL) with HC Vityaz. On 31 January 2013, having produced 18 points in 40 games, Panarin was traded to SKA Saint Petersburg in exchange for a draft pick. In the 2014–15 season, Panarin recorded 26 goals and 62 points in 54 appearances for SKA. He played a significant role in the team's championship run, scoring 20 points in 20 playoff games. He was named to the KHL first all-star team for the 2014–15 season.