On 18 August 2015, Đurđević was signed by Italian club Palermo. He marked his Serie A debut by scoring an 88th-minute equalizer after coming off the bench in a 2–2 home draw with Carpi on 13 September 2015. Unfortunately, in his second appearance for the "Rosanero", Đurđević fractured his ankle in a game against Milan at San Siro on 19 September 2015. He returned to action on 12 December 2015, being substituted at half-time by Alberto Gilardino, in an eventual 4–1 win over Frosinone at the Stadio Renzo Barbera. On 7 February 2016, Đurđević scored his second goal in Serie A, netting the equalizer in a 2–2 draw against Sassuolo. He collected a total of 14 league appearances and scored two times in the 2015–16 campaign.