Each episode of the show features a theme or central story which Terry and Strawn alternate recanting for the other and the listeners. The episodes air on Wednesday and usually range from 1–2 hours including introductions, though some episodes have been more lengthy given the cases or to allow time for the hosts and/or guests to discuss their reactions and theories. In a 2020 profile with Shoutout LA, the creators stated that they "research and discuss only things that [they] find interesting, that way the content never feels forced". Topics hail from around the world and throughout history, including but not limited to: popular folklore like The Mothman of West Virginia, internet cases and phenomena such as the Happy Valley Dream Survey and the Lake City Quiet Pills, true crime cases like the Setagaya family murders and the disappearance of Lars Mittank, and historical events like the Dyatlov Pass Incident, Operation Wandering Soul, and the Andes Flight Disaster. The hosts do thorough research about each case, often first providing background of the time and location for each story.