Following his transfer to the Florence-based club, Salifu was hardly utilized as a first team member. The young midfielder made his Serie A debut for Fiorentina on 23 April 2011 in a match against Cagliari, when he came on as a 90th minute substitute for former club captain, Adrian Mutu. He would eventually go on to make an additional 12 appearances throughout the 2011–12 Serie A season, before being loaned to Calcio Catania in June 2012. He has made 11 appearances in all competitions for the club since his arrival, generally serving as a reserve for the likes of Sergio Almirón, Francesco Lodi, and Marco Biagianti.