In 1961, Scuderia Serenissima entered the Formula One World Championship. They first entered a Cooper T51 for Maurice Trintignant at the 1961 Monaco Grand Prix, where he finished seventh. In Belgium, Trintignant retired on lap 23 with a broken gearbox after having qualified his car in 19th place. At the 1961 French Grand Prix, Scuderia Serenissima entered two cars. Again the Cooper for Trintignant and a De Tomaso for Giorgio Scarlatti. Trintignant finished in 13th place while Scarlatti retired on lap 15 when his engine broke down. At the German Grand Prix Trintignant retired on lap 12 when his engine broke down. In the 1961 Italian Grand Prix, Scuderia Serenissima again entered two cars, the Cooper for Trintignant and a De Tomaso for Nino Vaccarella. Trintignant finished the race in ninth place and Vaccarella retired on lap 13 when his engine broke down. In 1962, now called Scuderia SSS Republica di Venezia, they entered cars for Nino Vaccarella. In Monaco, Vaccarella failed to qualify for the race. Three races later in Germany, Vaccarella finished in 15th place. At the last race for the Scuderia in Italy Vaccarella finished in 9th place. In 1966 Serenissima supplied engines to McLaren. And at the 1966 British Grand Prix Bruce McLaren finished in sixth place, scoring one World Championship point.