In November 1622, the Nacotchtank faced their first death at the hand of colonial forces. This took place at the time of the Second Anglo-Powhatan War, a battle between English colonists and the Powhatan Confederacy. One tribe that the English closely allied with during this time was the Patawomeke (or "Patawomeck"). Though the Patawomeke were initially part of the Powhatan Confederacy, they were large enough so that they could lose such affiliation and side with the English. The Patawomeke, an Algonquian-speaking people, were established across from the Nacotchtank along the Potomac River, within what are now Stafford and King George counties of Northern Virginia. Such proximity to one another resulted in long-standing hostility, with the Chief of the Patawomeke referring to the Nacotchtank as their "mortal enemies." As such, the Patawomeck chief not only allied with the English, but also helped them in avenging the death of Fleet's party and in attaining corn by providing roughly 40-50 warriors to take part in a raid against the Nacotchtank. As a result of the raid, the English and Patawomeke together killed 18 Nacotchtank people and drove the rest from their cabins before plundering and burning the village. Captain Fleet remained a captive of the Nacotchtank, but would escape in 1626.