Lisicki began her 2016 season at the Hopman Cup representing Germany with Alexander Zverev. They were eliminated in the group stage with a 1–2 record, with their only victory coming against France. Her next tournament was the Sydney International. She lost in the second round to eventual champion, Svetlana Kuznetsova. Seeded 30th at the Australian Open, she was defeated in the second round by Denisa Allertová.