Prince Roman Fedorovich Sanguszko (c. 1537-12 May 1571) was a soldier and statesman of the Grand Duchy of Lithuania. He served as governor ("voivode") of Bracław and was hetman of Lithuania from 1567 until his death. He fought at the Battle of Ula in 1564 and belonged to the nesuhoizhskoy branch of the House of Sanguszko.