Van de Donk was selected to the final squad for the 2019 FIFA Women’s World Cup in France. Ahead of the tournament, ESPN named her to their top 25 player ranking. After winning all three of their group stage matches, the team finished at the top of their group and advanced to the knockout stage. During the Round of 16, the Dutch team faced 2011 champions, Japan, who had knocked them out of the 2015 World Cup. This time, the Netherlands won 2–1 and advanced to the quarterifinals. Of the match, "The Guardian" called Van de Donk "Holland's best player tonight." The Dutch team faced Italy in the quarterfinal and won 2–1 advancing to the semifinal for the first time in team history. Van de Donk played every minute of the semifinal against Sweden until the team scored a goal in the ninth goal of extra time and won the match 1-0 advancing to the final for the first time. The Netherlands faced 2015 champions the United States and lost 2–0. Van de Donk played every minute of the Final. Following the loss, she noted, "The growth [of women’s football in the Netherlands] is ridiculous. If I look at women’s football and the hype, it’s amazing. I think that’s what I’m most proud of, that we got so much respect from the Netherlands."