Pazzini began the 2011–12 season on a weak note, failing to score until the fifth matchday in a 3–1 victory over Bologna. He then scored in the next match after a dribble from teammate Yuto Nagatomo in a 3–2 away victory against CSKA Moscow. He later suffered a three-month goal drought until he scored Inter's opener in a 2–0 victory against Fiorentina. Pazzini also added another goal later that month against Lecce and scored in Inter's opening match of the 2012 calendar year in a 5–0 victory against Parma. Owing partially to the excellent form of his teammate Diego Milito and partially due to a lack of consistency in managerial preferences and squad selection, Pazzini made a majority of his appearances for Inter during the 2011–12 season as a substitute off the bench. As such, Pazzini was only able to score five goals in Serie A for the season and was often frustrated in front of goal in European competition as well.