He finally got his big break in 1991 when he was signed as replacement for Ferrari-bound Tyrrell team leader Jean Alesi. With a healthy group of sponsors, 1990 spec Honda engines, Pirelli tyres and a development of the successful 020 chassis much was expected of the combination, with some predicting race wins. While his season started off with 4th place at Phoenix many of the front runners had retired without Modena getting near them. The wet conditions at Imola saw similar attrition allowing Modena to reach 3rd place before transmission failure. The following race at Monaco saw an even better performance as he qualified on the front row alongside his friend and World Champion Ayrton Senna, harrying the McLaren driver until being held up in traffic and suffering a violent engine failure. A steadier run in Canada was rewarded with 2nd place after Nigel Mansell retired on the final lap. After that Modena's form dropped off badly as Pirelli struggled to develop a consistent race tyre while the heavy Honda engines made the 020 chassis (originally designed for the Cosworth DFR V8) difficult to balance. While Modena continued to qualify frequently in the top half of the grid he struggled in races, only scoring one more point for 6th place at the Japanese Grand Prix.