1st Indiana Cavalry Regiment, also known as the 28th Regiment of Volunteers was a cavalry unit that served in the Union Army during the American Civil War. Organized in August 1861, it did most of its fighting in the state of Arkansas. The regiment was in action at Cotton Plant, Helena, Bayou Fourche, Pine Bluff, Mount Elba, and Marks' Mills. One company was detached and fought in several actions in the Vicksburg campaign. The regiment was discharged in June 1865.