Once in North Africa, the Regiment underwent further training at Casablanca. By April 29, 1944, the Regiment had landed in Italy and moved on to Corsica. On September 22, 1944, the 65th Infantry landed in France and was committed to action on the Maritime Alps at Peira Cava. On December 13, 1944, the 65th Infantry, under the command of Lieutenant Colonel Juan César Cordero Dávila, relieved the 2nd Battalion of the 442nd Infantry Regiment, a Regiment which was made up of Japanese Americans under the command of Col. Virgil R. Miller, a native of Puerto Rico. The 3rd Battalion fought against and defeated Germany's 34th Infantry Division's 107th Infantry Regiment. There were 47 battle casualties, including Private Sergio Sanchez-Sanchez and Sergeant Angel Martinez from the town of Sabana Grande, who became the first two Puerto Ricans to be killed in combat action from the 65th Infantry as a result of a German assault on Company "L". On March 18, 1945, the regiment was sent to the District of Mannheim and assigned to military occupation duties. Twenty-three (23) soldiers of the regiment were killed in action.