In April 2018, Salcedo was listed as one of three center-backs nominated for the Bundesliga "Team of the Season", alongside Mats Hummels and Jerome Boateng. On 14 May, Eintracht Frankfurt announced they had signed Salcedo to a four-year contract, tying him to the club until 2022. On 19 May, Salcedo won the DFB-Pokal with Eintracht Frankfurt after they defeated Bayern Munich 3–1 in the final.