On 23 October 2011, Di Natale scored a brace in a 3–0 defeat of Novara which sent Udinese to the top of the Serie A table. On 13 May 2012, he opened the scoring against Catania on the final matchday of the Serie A season, and Diego Fabbrini added a second-half strike to secure four-straight Serie A victories and ensure Udinese a place in next season's UEFA Champions League qualifying round. On 4 July 2012, Di Natale signed a new two-year contract with the club.