Seppi started his 2013 season at the Hopman Cup, partnering 2010 French Open champion Francesca Schiavone. Seppi lost all three of his singles rubbers, to Novak Djokovic, Bernard Tomic and Tommy Haas, but combined with Schiavone to win all their doubles rubbers, against the Serbian pairing of Djokovic and Ana Ivanovic, the Australian pairing of Tomic and Ashleigh Barty and the German pairing of Haas and Tatjana Malek. The win over the Serbian pair of Djokovic and Ivanovic marked the first victory for Seppi and Schiavone over their respective opponents in any capacity, as Seppi has never defeated Djokovic and Schiavone has never beaten Ivanovic in professional singles matches.