She started her year at the 2012 Hopman Cup partnering Lleyton Hewitt. In the first tie against Spain, Gajdošová put Australia up by beating Medina Garrigues in three sets. They eventually lost the tie by losing the deciding mixed doubles, 9–11 in the final set tiebreak despite leading 5–1. In the second tie against France, Gajdošová left the court in tears after losing to Marion Bartoli, 0–6, 0–6. In the final tie against China, Gajdošová lost to Li Na, however Australia won the tie in the mixed doubles. She then played at the Hobart International, where she was the defending champion. In the first round, she defeated Ayumi Morita in straight sets and then defeated Anastasia Rodionova in a very tough second-round match. Although she started well against qualifier Mona Barthel, she lost in three sets to the eventual champion.