Soon, Piliso-Seroke was promoted to national secretary of YWCA, and she began travelling to international YWCA conferences to speak about her experiences with apartheid. In 1975, she became a member of the Executive Committee of the World YWCA in Geneva, Switzerland, and remained in that position until 1976. That year, the Soweto Uprising took place in South Africa. When Piliso-Seroke and the rest of the Executive Committee visited Soweto afterwards, they were detained by the Orlando Police Station for four days.