The second chapel on the left, dedicated to St. Anthony of Padua (ca. 1195-1231), was instituted by Pedro Machado de Brito, who left a legacy requesting that he and his descendants be buried here. It was built in 1635 but partly destroyed in the earthquake of 1755. Its decoration reflects the early classical and geometric style of the chancel, Baroque elements of the 18th century, and the restoration efforts of the 19th century. The multicoloured statue of St. Anthony is of upholstered wood of the Mannerist period. On the side walls are two 18th-century paintings by Vieira Lusitano (1699–1783), royal painter to King John V: "St. Anthony Preaching to the Fish" and "The Temptation of St. Anthony and his Vision of the Virgin".