US 15 continues south as the James Madison Highway toward Farmville, while US 33 continues paralleling the railroad along Spotswood Trail. At Trevilians, US 33 becomes concurrent with SR 22 (Louisa Road). US 33 and SR 22 head into the town of Louisa as Main Street. On the east side of this county seat, the highways intersect SR 208 (Courthouse Road). SR 208 joins the two highways for a short distance until the state highways diverge from US 33, following the railroad east along Davis Highway toward Mineral, near the epicenter of the 2011 Virginia earthquake, with US 33 continuing southeast along Jefferson Highway. The route passes south of Northeast Creek Reservoir before a short concurrency with US 522 in Cuckoo, where US 522 heads north as Pendleton Road toward Mineral and south as Cross County Highway toward Goochland. Continuing eastward, US 33 then approaches the Richmond Metropolitan Area.