Kambule taught in Zambia, Malawi as well as several schools in South Africa before being appointed Principal of Orlando High School in Soweto in 1958. He campaigned to ensure the children had the best education possible, despite the restrictions of the Bantu Education Act, 1953. Orlando High School had a library named after Robert Birley, a visiting professor at the University of the Witwatersrand. He led the Rand Bursary Fund, a support program that provided scholarships for pupils in need. The fund allowed more than 1,000 students to complete high school. His former pupils included Desmond Tutu and Jackie Selebi. In 1976 during the Soweto uprising, the schoolchildren revolted against being forced to learn in the Afrikaans language. An undetermined number of children were shot dead by police, and education in townships fell apart. Kambule resigned in 1977 to protest against the Department of Bantu Education, and became the head of Pace College.