In the middle of the 14th century, the region was conquered by Stefan Dushan for Serbia, but it did not take long for the Serbian Empire's control over the region to fragment as the local families reasserted control. Four decades later, the Battle of Savra (as one of the plains of Myzeqe was known in the Middle Ages) marked the ascendancy of the Ottoman Empire in the region. In the 15th century, the Muzaka family and other local Albanian lords joined Skanderbeg's League of Lezhë to try to contain the growing dominance of the Ottomans, but after a long conflict, Myzeqe as well as wider Albania ended up decisively under Ottoman rule until the early 20th century. Some of the local Albanian rulers as well as some of the population ended up fleeing to foreign countries, but some of the rulers stayed and became integrated into the Ottoman power apparatus.