In the late 1950s, Manuel Neri was a member of the artist-run cooperative gallery, Six Gallery in San Francisco, along with Joan Brown, Bruce Conner, Jay DeFeo, and other artists. In October 1955, he helped organize "6 Poets at 6 Gallery" Six Gallery reading, a landmark Beat era event where Allen Ginsberg gave the first public reading of Howl. In 1959, Neri was an original member of Bruce Conner's Rat Bastard Protective Association. In the 1960s, he was associated with the Bay Area Figurative Movement. He was married to Bay Area artist Joan Brown from 1962 to 1966, though their relationship and artistic collaboration dated back several years prior to this.