Wozniacki began her season by representing Denmark at the 2012 Hopman Cup with Frederik Nielsen as her partner. Wozniacki won two of her three round robin matches in singles, defeating Bethanie Mattek-Sands and Tsvetana Pironkova, then lost to world No. 2 Petra Kvitová. Her first WTA event was the Apia International Sydney. Wozniacki defeated Dominika Cibulková when trailing 4–0 in the third set. She lost to Agnieszka Radwańska in three sets in the quarterfinals, after serving for the match at 5–4 up in the second set.