The brigade participated in the First Italian War of Independence, fighting in the battles of Santa Lucia, Goito, Pastrengo and Novara, where the 5th Regiment was awarded a Silver Medal of Military Valor. In 1855 the brigade provided two battalions for the Sardinian Expeditionary Corps in the Crimean War. In the Second Italian War of Independence the brigade was employed in the battles of Magenta and Solferino. The brigade was awarded a Gold Medal of Military Valor for its conduct at Solferino. Furthermore, the IV Battalion of the 5th Regiment was awarded a Bronze Medal of Military Valor for its conduct during the Battle of Aspromonte. In the following years the brigade was employed in Calabria and the region of Salerno to suppress the popular revolt of the peasant population against the annexation of the Kingdom of the Two Sicilies into the new Kingdom of Italy. In the Third Italian War of Independence the brigade fought in the Battle of Custoza.