In 2010–11 season Di Francisca earned a medal in six out of the seven World Cup events in which she took part, including two golds in Seoul and Tauberbischofsheim. At the European Championships she met again Vezzali in the final. After being led for the first two periods, Di Francisca levelled the score and hit twice in the last ten seconds to win the bout 10–8 and claim her first continental title. Vezzali took her revenge at the World Championships in Catania when they met once again in the final. Vezzali took a 0–6 lead in the first bout and kept until the final score of 7–15. "I didn't understand anything", commented Di Francisca. "It's as if she had a walkie talkie earpiece suggesting everything I was going to do. She anticipated everything and riposted." The silver medal however strengthened her ranking and she won the 2010–11 World Cup series.