Ophryneion is rarely mentioned in extant sources from Antiquity. Herodotus mentions that in 480 BC Xerxes passed by his way up the coast before crossing to Europe at nearby Abydos. Later that century, it was one of the Actaean cities which Mytilene lost control of following the end of the Mytilenean revolt in 427 BC. An inscription from Athens dating to 414/413 BC, which records property confiscated from Athenian nobleman implicated in the mutilation of the Herms, indicates that a relative of Alcibiades, Axiochus, earned revenues from land in the territory of Ophryneion. In the summer of 399 BC, Xenophon stopped here to offer sacrifice while marching home with the Ten Thousand. Later in the 4th century BC, a speech of the orator Demosthenes relates how a man who had been exiled from Byzantium, Parmeno, had decided to settle at Ophryneion, but was forced to move when an earthquake struck the Chersonese and brought down his house, presumably causing similar damage in the rest of the town. Some time shortly after 316 BC, the bones of Hector were moved from Ophryneion to Thebes (see above, The Tomb of Hector), although Strabo's description of Hector's precinct at Ophryneion in the 1st century AD suggests that he was still worshipped there after his bones had moved. Strabo indicates that before the Treaty of Apamea in 188 BC, Ophryneion had been under the sway of Dardanus to the north-east, whereas after this point it instead belonged to Ilium. Pot sherds and coins found at Ophryneion indicate that the site was continuously occupied until at least the Byzantine period, but with the exception of its fame as the one-time location of the bones of Hector, we hear no more about it.