The area began to attract refugees from nearby Mexico who were fleeing the Mexican Revolution of 1910. The Castolon area was the site on a U.S. Army encampment, called Campo Santa Helena, to house units patrolling the Mexican–American border. However, by the time the camp was complete in 1920 the border was quiet and the camp buildings were never used by the Army. In 1921 the La Harmonia Company was established in the barracks, operating a trading post and farming cotton. The La Harmonia Company was established in 1918 by Howard Perry, who owned the Chisos Mining Company in Terlingua, in partnership with Wayne Cartledge. Cartledge and his son Eugene chose the name and managed the company. The La Harmonia Company lasted until 1961, when it was sold to the National Park Service. The store burned down in a fire in May 2019.