Born about 1645, it is likely that Exquemelin was a native of Honfleur, France, who on his return from buccaneering settled in Holland, possibly because he was a Huguenot. In 1666 he was engaged by the French West India Company and went to Tortuga, where he worked as an indentured servant for three years. There he enlisted with the buccaneers, in particular with the band of Henry Morgan, whose confidante he was, probably as a barber-surgeon, and remained with them until 1674. Shortly afterwards he returned to Europe and settled in Amsterdam where he qualified professionally as a surgeon, his name appearing on the 1679 register of the Dutch Surgeons' Guild. However, he was later once again in the Caribbean as his name appears on the muster-roll as a surgeon in the attack on Cartagena in 1697.