Neuner is the most successful female biathlete in the history of Biathlon World Championships. She has won seventeen medals, twelve gold, four silver and one bronze. At her debut during the 2007 World Championships in Antholz, Italy, Neuner won three titles (sprint, pursuit and relay). One year later at the 2008 World Championships in Östersund, Sweden, she again claimed three gold medals, winning the mass start, relay and mixed relay events. Neuner did not win a title at the 2009 World Championships in Pyeongchang, South Korea; her best result was the silver medal in the relay event. She won her second mixed relay gold in Khanty-Mansiysk, Russia, in 2010. At the 2011 World Championships, she won three more titles (sprint, mass start, relay) and two silver medals (pursuit and mixed relay). At her final championships in 2012, Neuner won her world titles eleven (sprint) and twelve (relay), as well as her fourth silver (pursuit) and her first bronze medal (mixed relay).