She narrowly missed qualifying for the Olympics in Athens in 2004, but during the Paralympics that were held in the same city, she won one silver and five gold medals. In the same year, her courage and achievements were acknowledged with a nomination for the Laureus World Sportsperson of the Year 2004 with Disability Award. At the 2006 Commonwealth Games she repeated her previous performance by winning the same two golds as she had in Manchester. In 2006 Du Toit also won six gold medals at the fourth IPC World Swimming Championships, finishing third overall in a race which included 36 males and 20 females.