Di Grassi was announced as one of two drivers of the brand new Virgin Racing team on 15 December 2009 and would be partnered by his former GP2 Series rival Timo Glock in a deal predicted by BBC Radio Sheffield. An important factor in his decision was the chance to work with John Booth, the Virgin team principal. It was reported by "The Daily Telegraph" that di Grassi had also provided Virgin with £5 million worth of sponsorship. Writing in "The Guardian"'s 2010 Formula One supplement, Alan Henry and Rob Bagchi predicted that Glock would outperform di Grassi throughout the season. He retired from the opening two rounds of the season (Bahrain and Australia) due to hydraulic problems. However his fortunes improved at Sepang where he took his first (and best finish) of the season with a 14th in spite of having to do the second half of the race in fuel conservation mode due to pick-up and fuel capacity problems.