Henderson had problems with a badly strained right hamstring throughout the season, which limited him to just 20 games played, and caused him to miss 104 consecutive games between May 5 and the start of September. He hit just 9-for-63 (.143) for the season, with 2 RBIs. While Oakland won the AL West (then lost to Toronto in six games in the 1992 ALCS), Henderson was left off of the postseason roster due to his injury.