The ship saw extensive service in World War II, which Italy entered in June 1940. She frequently operated against British convoys to Malta in the Mediterranean, and after the North African Campaign began, she escorted Italian convoys to support the Italo-German forces fighting there. In the course of these operations, she took part in the battles at Calabria, Cape Spartivento, and First and Second Sirte. "Gorizia" was also attacked numerous times by Allied bombers while in port, culminating in a major raid in April 1943 that inflicted serious damage to the ship. Under repair when Italy surrendered to the Allies in September, the ship was seized by occupying Germany forces, who found the ship to be unusable and so abandoned her. Italian and British frogmen tried unsuccessfully to sink the ship in 1944. After Germany's defeat in 1945, the Italian Navy determined the ship was beyond economical repair, and so she was broken up for scrap in 1947.