It was during the following Ming dynasty, which was once again led by Han Chinese, that Guizhou was formally made a province in 1413. The Ming established many garrisons in Guizhou from which to pacify the Yao and Miao minorities during the Miao Rebellions. Chinese-style agriculture flourished with the expertise of farmers from Sichuan, Hunan and its surrounding provinces into Guizhou. Wu Sangui was responsible for the ousting the Ming in Guizhou and Yunnan during the Manchu conquest of China. During the governorship-general of the Qing Dynasty's nobleman Ortai, the "tusi" system of indirect governance of the southwest was abolished, prompting rebellions from disenfranchised chieftains and the further centralization of government. After the Second Opium War, criminal triads set up shop in Guangxi and Guizhou to sell British opium. For a time, Taiping Rebels took control of Guizhou, but they were ultimately suppressed by the Qing. Concurrently, Han Chinese soldiers moved into the Taijiang region of Guizhou, married Miao women, and their children were brought up as Miao.