Following shakedown and post-shakedown shipyard availability, "Burlington" got underway from San Pedro, California, on 1 August 1944. Her first assignment took her to Espiritu Santo, where she performed patrol and escort duties in support of operations in western New Guinea. Then, from 16 October 1944 to 18 November 1944, she escorted convoys between New Guinea and the Philippine Islands in support of the invasion of Leyte. She departed the war zone on 3 December 1944 to return to California and arrived at San Francisco, California, on 25 December 1944 for repairs.