Opechancanough (; 1554–1646) was paramount chief of the Powhatan Confederacy in present-day Virginia from 1618 until his death. He had been a leader in the confederacy formed by his older brother Powhatan, from whom he inherited the paramountcy. Opechancanough led the Powhatan in the Second and Third Anglo-Powhatan Wars, including the Jamestown massacre of 1622. In 1646, the aged Opechancanough was captured by the English and taken to Jamestown, where he was murdered by a soldier assigned to guard him.