In October, 2016, Shamlian interviewed Arianne Zucker, the actress who Donald Trump made suggestive comments about in an Access Hollywood video recorded in 2005. Also in 2016, she reported from the scene of the Orlando nightclub shooting and from France, just hours after the 2016 Nice truck attack, where she was vacationing with her family. Previously, she has reported on national and international events for NBC, including the Deepwater Horizon oil spill and Hurricane Katrina. In 2007, Shamlian conducted the first evening network broadcast interview with Michelle Obama, the wife of then presidential candidate Barack Obama, on the NBC Nightly News.