The zenith of the Braganza dynasty came with the long reign of D. João V (1706–1750), who ruled with grandeur and piety. The reign of D. José I, son of D. João V, was marked by the great earthquake, which struck Lisbon in 1755. The political genius of his reign was the 1st Marquis of Pombal. The end of the 18th century was characterized by stability, under the rule of Dona Maria I (1777–1816), who discharged Pombal at her accession. Unfortunately Dona Maria became psychologically unstable, displaying similar symptoms to George III of the United Kingdom in his later years.