Lavezzi scored his first goal of the 2011–12 campaign in a commanding 3–1 victory over Cesena on 10 September, opening the scoring in the third minute after controlling a long-ball from Hugo Campagnaro. Lavezzi was named "Man of the Match" as he volleyed in a lobbed pass from strike partner Edinson Cavani to send Napoli to a 2–0 victory over Udinese on 26 October. Shortly before the winter break, Lavezzi netted once and provided an assist for one of Cavani's goals as Napoli outclassed Lecce 4–2.