He scored his first goal in Serie A for Inter on 21 October in a 2–0 victory at the San Siro against Catania. On 4 November, he scored the final goal in a 1–3 win against defending league champions Juventus while on 8 November, he scored a brace in a Europa League match against Partizan (1–3) that took Inter into the competition's round of 32 with two group stage matches to spare. During a second round match in the Coppa Italia against Hellas Verona on 18 December, after an injury to goalkeeper Luca Castellazzi and after all three of the club's substitutions were exhausted, Palacio, wearing Vid Belec's jersey number 27, was put into goal for the final 15 minutes of the match. He did not concede a goal to the opposition in a 2–0 final win and even made a fine save in the 91st minute, stopping a diving header from the right side of goal by Verona midfielder Alessandro Carrozza.