On 9 June 2008, McGuire temporarily hosted "A Current Affair" while regular host Tracy Grimshaw was on leave. This saw the ratings of the show increase with 1.42 million viewers tuning in to watch on his first night of hosting. Rival program "Today Tonight" still beat "ACA" with 1.470 million viewers. The ratings for ACA slumped to 1.217 million viewers the following Tuesday while Today Tonight achieved 1.549 million viewers. In February 2009, McGuire hosted a telethon for the victims of the Victorian bushfires. Since April 2009, McGuire has hosted the weeknight game show "Millionaire Hot Seat" program which airs at 5:00 pm. He also hosted a fundraising telethon from Brisbane on 9 January 2011 for victims of the 2010–2011 Queensland floods alongside Leila McKinnon and Karl Stefanovic at Suncorp Piazza.