He and his wife were often seen driving in a four-wheel-drive Land Rover truck in Afghan cities. After the April 1978 Saur Revolution in Afghanistan, Dupree was arrested and deported from the country. He moved back to the United States but often visited neighboring Pakistan to monitor the Soviet–Afghan War. He has worked with the mujahideen forces who were fighting the Soviet-backed government of Afghanistan. He spent time in Peshawar, Pakistan, along with his wife, assisting Afghan refugees. He had previously stayed in Pakistan as a Fulbright Scholar and as an advisor on Afghan affairs to the US ambassador in Pakistan.