The 2nd U.S. Artillery, Battery E was an artillery battery that served in the Union Army during the American Civil War. The unit fought at the battles of First Bull Run in 1861 and Yorktown, the Seven Days, Second Bull Run, Chantilly, Antietam, and Fredericksburg in 1862. The following year, Battery E moved to the Western Theater where it served at Vicksburg and Knoxville. In 1864, the unit transferred back to the Eastern Theater where it fought at the Wilderness, Spotsylvania, Totopotomoy, and Cold Harbor. For the rest of the war it became part of the Washington D.C. garrison.