On 15 June 2019, Miedema became the all-time top scorer of the Netherlands women's national football team after scoring her 60th goal in a 3–1 win against Cameroon at the 2019 FIFA Women's World Cup in France. She passed the record held by Melis and extended her lead of the men's team's leading scorer, Robin van Persie. During the Netherlands' 2–0 quarter-final victory over Italy, she scored both goals, was named Player of the Match, and led the Dutch team to its first–ever World Cup semi-final. Miedema's performance throughout the tournament was instrumental in leading the Netherlands to the final, where they fell 2–0 to defending champions United States.