Sexton started all five 2016 Six Nations matches. He scored 11 points (three penalties and a conversion) in a 16–16 draw with Wales. In the second match he scored all of Ireland's points in a 9–10 defeat to France. In the third match he scored three points in a 10–21 defeat to England. In the penultimate match of the tournament he scored nine points (a penalty and three conversions) in a 58–15 win against Italy. In the last match of the tournament he scored 15 points (three penalties and three conversions) against Scotland. Despite Sexton's getting sin binned in the 76th minute for a maul infringement, Ireland won 35–25.