Medrán made his first-team – and La Liga – debut on 18 October 2014, replacing Luka Modrić in the 79th minute of a 5–0 away rout of Levante UD. On 9 December, in his UEFA Champions League maiden appearance, he scored his first senior goal for the club after replacing Gareth Bale in the 83rd minute, netting the last in the 4–0 defeat of PFC Ludogorets Razgrad for the group stage five minutes later. Later that month, he was part of the squad that won the FIFA Club World Cup in Morocco, but did not take to the field.