He was also a member of the winning Biathlon World Championship relay team in 2001, and the 2004 team which won bronze. At the Biathlon World Championship 2007 in Antholz, Defrasne earned a bronze medal, in the 12.5 km pursuit and a silver medal in the Mixed Relay event. In 2009 at the World Championships in Pyeongchang, Defrasne was part of the victorious mixed relay team.