Wood earned two wins in the Divisional Series against the Atlanta Braves and was the starter in Game 3 of the 2003 National League Championship Series, which the Cubs won in extra innings. However, the Cubs lost in seven games to the eventual World Series champion Florida Marlins. In the decisive Game 7, Wood hit the first home run by a pitcher in an NLCS game since another Cub, Rick Sutcliffe, did so in Game 1 in 1984. However, the Marlins won the game 9-6. Wood was the losing pitcher and the Cubs were eliminated.