In the 2014 National League Championship Series, Ishikawa batted 5-for-13 (.385) with 7 RBIs. He recorded the game-winning RBI in Game 1 and drove in three runs via a bases-loaded double in Game 3. In Game 5, with the Giants leading the series three games to one, Ishikawa hit a 3-run walk-off home run in the bottom of the ninth inning off of St. Louis Cardinals pitcher Michael Wacha to clinch the pennant for the Giants and their third World Series appearance in the past five seasons. Ishikawa's home run was the first to send a National League team to the World Series since Bobby Thomson's Shot Heard 'Round the World in 1951. Ishikawa's home run was the first ever to end an NLCS and the fourth to end any LCS, after Chris Chambliss (1976 ALCS), Aaron Boone (2003 ALCS), and Magglio Ordonez (2006 ALCS).