In 1996, Zammit Lupi started working as a photographer with the "Times of Malta" and in the following year he became a freelance correspondent for Reuters. His work documents the migration crisis in the Mediterranean, the devastating Tsunamis of Southeast Asia, the Millennium Development Goals in different areas of Africa, the 2009 L'Aquila earthquake, the Costa Concordia disaster, the Libyan conflict, and other international events.