The church was destroyed on 14 October 1529, during the first siege of Vienna. It was rebuilt in 1534 and renovated in 1668. Both the church and the hospital were destroyed in the second siege of Vienna in 1683, whereafter only the church was rebuilt. In 1745, Cardinal Sigismund von Kollonitz donated an artefact belonging to Saint Severinus to the church, which has been revered as a holy relic ever since. The church spire was built in 1752.