On 27 September, Valverde scored Real Madrid's first goal of the 2020–21 season away to Betis in La Liga in an eventual 3–2 win and was selected as the 'King of The Match'. This was also his 50th La Liga match for Los Blancos. One month later on 24 October, Valverde scored against FC Barcelona at the Camp Nou in just five minutes in an eventual 3–1 league win. Valverde became just the second Uruguayan to score in El Clásico (after Luis Suárez) and the first for Real Madrid. One week later Valderde scored again, against Huesca in a 4–1 league win at the Alfredo Di Stéfano Stadium. This was his third goal of the season, meaning he had already scored more this season than the entirety of the previous campaign.