Eight months after the events of "Re-Animator", doctors Herbert West and Dan Cain are working as medics in the middle of a bloody Peruvian civil war. In the chaos of battle and with plenty of casualties to work on, they are free to experiment with West's re-animation reagent. When their medical tent is stormed by the enemy troops, West and Cain return home to Arkham, Massachusetts. There, they resume their former jobs as doctors at Miskatonic University Hospital, and West returns to the basement laboratory of Cain's house to continue his research.