The regiment moved to Union City, Tennessee, where 150 men died from the effects of measles. Later it was involved in the conflicts at Shiloh and Baton Rouge, and in October, 1862, contained 249 effectives. Attached to Buford's and Beall's Brigade, Department of Mississippi and East Louisiana, the 10th was part of the garrison that surrendered at Port Hudson on July 9, 1863. After being exchanged, the men returned to Arkansas and were reorganized as the 10th or Witt's Cavalry Regiment.