The first of the Anglo-Powhatan Wars occurred from 1610 to 1614, starting after a raid from the Virginian settlers killed dozens of Powhatan. In 1622, the second Anglo-Powhatan War broke out when the Powhatan attacked Jamestown and killed 347 settlers, roughly 30% of the settlement's population at the time. In 1644, the Powhatan attacked Jamestown in the same method as the 1622 attack. They killed 400 settlers, about 10% of Jamestown's population at the time, which started the third Anglo-Powhatan War.