Reynders won her first world road title in 1959. In 1961 she won her second, defeating Burton and Elsy Jacobs, and also won the world individual pursuit title the same year. She won two more road world titles, in 1963 on home ground in the Belgian city of Ronse, and in 1966 at the Nürburgring in West Germany, and another two track rainbow jerseys, in 1964 and 1965. She initially retired from competition in 1967, however she returned to racing in 1976 at the age of 39: she took her final world championship medal, a bronze, at that year's Road World Championships. She retired a second time the following year.