Carl Bridenbaugh is one of the historians who have speculated that Don Luís was the same person as Opechancanough, younger half-brother (or close relative) of the Powhatan (Wahunsonacock), paramount chief of an alliance of Algonquian-speakers in the Tidewater. Opechancanough succeeded to the post of paramount chief and led two noted attacks on Jamestown settlers, one in 1622 and another in 1644, in an effort to expel them. The Virginia anthropologist Helen C. Rountree has suggested this is an unlikely coincidence, arguing that the Virginia Indians may have claimed otherwise "in an attempt to disavow their association with Opechancanough, whose memory was still so detested by the English due to the attack of 1622." Alternatively, Don Luís may have been the father of Powhatan who had arrived from Spanish dominion in the West Indies according to English accounts.