Hülkenberg made his debut at the , recovering from an early spin to finish in fourteenth position. At the second round in Australia, he was involved in a first-lap incident with Kamui Kobayashi, after the Japanese driver's front wing failed and sent him into the barrier, rebounding into the path of Hülkenberg. At the third round in Malaysia, Hülkenberg made it to Q3 for the first time, qualifying in fifth place; out-qualifying teammate Barrichello for the first time. Hülkenberg looked set to finish eleventh in the race until Fernando Alonso blew his engine three laps from the end, thus promoting Hülkenberg to tenth place and with the new-for-2010 points system, Hülkenberg along with Jaime Alguersuari scored their first points in Formula One. He was tenth again at Silverstone, and at the he finished sixth, a career best. He also picked up points finishes in Italy, Singapore, and Korea. At the , Renault driver Vitaly Petrov misjudged a move at the start and cut across Hülkenberg's nose thus taking them both out of the race. Towards the end of the season there were reports that he could lose his seat at Williams to the GP2 Series champion Pastor Maldonado due to the money Maldonado could bring to the team. Force India's Adrian Sutil was also linked to replace Hülkenberg at Williams.