In July Seryugin was appointed commander of the 160th Rifle Division, which as part of the 6th Army of the Voronezh Front distinguished itself in the Battle of Voronezh. Subsequently, the 160th fought as part of the Voronezh, and from December the Southwestern Fronts, with an active role in Operation Little Saturn. He was wounded on 18 February 1943 while departing for reconnaissance in the area of Height 179.6 and evacuated to a hospital for treatment, being replaced by deputy division commander Colonel Aleksei Baksov. Seryugin resumed command of the division on 9 April, and the 160th was converted to the 89th Guards Rifle Division on 19 April. He led it in the Donbas strategic offensive, the Battle of the Dnieper, the Nikopol–Krivoi Rog offensive, the Bereznegovatoye–Snigirevka offensive, and the Odessa Offensive. Seryugin was promoted to major general on 1 September 1943. Between 2 June and 5 July 1944 Seryugin temporarily commanded the 49th Rifle Corps in the second echelon of the 53rd Army of the 2nd Ukrainian Front during the hospitalization of corps commander Major General Gury Terentyev. After the latter returned, Seryugin resumed command of the 89th Guards, which fought in the Second Jassy–Kishinev offensive as part of the 5th Shock Army. He was evaluated as having "skillfully led divisional units" in the breakthrough of Axis defenses in the Kishinev sector and the repulse of tank counterattacks. Seryugin was described as acting "energetically and competently" despite the presence of Axis tanks in the rear of the division.