Until the late 17th century, the name of the town was spelled "Wyszemierzyce" (also "Vyszemierzice" and "Wyssemierzyce"). The name comes from a male given name Wyszemir. Wyśmierzyce was granted Magdeburg rights on December 12, 1338, and like many other locations in northern Lesser Poland, was stripped of them after January Uprising (1869), by the government of Tsarist-controlled Congress Poland. In 1378, first Roman Catholic parish was opened here, and in 1657, the town was completely destroyed by the army of Transilvanian prince George II Rakoczi during the Swedish Invasion of Poland. After the Partitions of Poland, Wyśmierzyce at first belonged to Austria’s West Galicia, and in 1815 it became part of Tsarist-controlled Congress Poland, from 1844 on as part of Radom Governorate. The village regained its town charter in 1922, when it belonged to Second Polish Republic’s Kielce Voivodeship.