In 1976, with the spread of the Soweto uprising into other areas of the country, Mufamadi became a member of Zoutpansberg Students Organisation, which led to the boycotts in Venda during October 1977. Many student leaders were arrested, and others, including Mufamadi, went underground. When the schools re-opened, he was refused re-admission and was briefly prevented from completing his schooling. He moved to Johannesburg and enrolled at an international Correspondence College.