Cape Verde sent a delegation to compete at the 2000 Summer Olympics in Sydney, Australia from 15 September to 1 October 2000. This was Cape Verde's second appearance at a Summer Olympic Games after the 1996 Summer Olympics in Atlanta four years prior. The Cape Verdean delegation to Sydney consisted of two track and field athletes, Isménia do Frederico and António Zeferino, who were both making their second Olympic appearance. Do Frederico did not advance out of her heat in the women's 100 meters, while Zeferino finished 67th of 81 finishers in the men's marathon.