He then turned to coaching and successfully managed Independiente, leading them national league titles in 1963 and 1970. In 1968, he led Vélez Sarsfield to the Argentine championship; it was the club's first national title. His greatest success was winning the 1964 and 1965 Copa Libertadores cups, also finishing as runners-up in the 1964 and 1964 Intercontinental Cups, losing both times to Inter Milan, at the time coached by fellow Argentine Helenio Herrera.