Elise Matthysen (born 13 July 1992 in Kalmthout) is a retired Belgian swimmer who specialised in breaststroke. During the 2008 European Aquatics Championships she came 4th in the final of the 100 m breaststroke in which she broke the national record of Brigitte Becue. With this excellent performance, she managed to qualify herself for the Olympics. At the Olympics, while still only 16 years of age, she qualified for the semi-finals for both the 100 m breaststroke and 200 m breaststroke with a new Belgian record; eventually she finished respectively 13th and 16th overall.