After some friendly games and qualifiers, Schortsanitis' first appearance at a major FIBA competition with the senior men's Greek national basketball team was at the 2006 FIBA World Championship, which was held in Japan. He helped Greece to win the silver medal at the tournament, after they defeated Team USA, by a score of 101–95, in the semifinals. Schortsanitis scored 14 points, in 17 minutes played during the game. He also played with Greece at the 2008 Summer Olympics.