Prior to and during Israel's 1982 invasion of Lebanon, al-Wazir planned numerous attacks inside Israel against both civilian and military targets. He prepared Beirut's defense against incoming Israeli forces. Nonetheless, the Israeli military prevailed and al-Wazir was exiled from Lebanon with the rest of the Fatah leadership. He settled in Amman for a two-year period and was then exiled to Tunis in 1986. From his base there, he started to organize youth committees in the Palestinian territories; these eventually formed a major component of the Palestinian forces in the First Intifada. However, he did not live to command the uprising. On 16 April 1988, he was assassinated at his home in Tunis by Israeli commandos.