When Ferdinando died in 1626, his brother Vincenzo II (1594–1627), also a cardinal, succeeded him as Duke of Mantua and Montferrat. Despite marrying, following the resignation of Ferdinando and the expulsion of Vincenzo from the Sacred College of Cardinals (for violating the celibacy), neither produced any legitimate children. A new crisis erupted when Vincenzo II died on 26 December 1627, leading to the War of the Mantuan Succession (1627–1632).