On 9 March 2015, the Manor Marussia team announced that Merhi would drive in the , alongside Britain's Will Stevens. However, Marussia did not compete in Australia due to a technical problem. In the Malaysian Grand Prix Merhi competed in his first Formula One race despite problems to his teammate Stevens' car. Merhi failed to set a lap time within 107% of the fastest time in Q1, but the race stewards allowed Merhi to start the race. Merhi finished in 15th place, 3 laps down on race winner Sebastian Vettel. In the Chinese Grand Prix, Merhi finished in 16th place behind his teammate Stevens. In Bahrain and Spain Merhi also finished behind Stevens. However, in the Monaco Grand Prix Merhi finished in 16th ahead of Stevens. In the Canadian Grand Prix, Merhi qualified ahead of Stevens and would start in 16th thanks to penalties to Sebastian Vettel and Max Verstappen. As well as that Jenson Button failed to set a lap time in qualifying because of an engine issue. In the race, Merhi was a minute ahead of Stevens but on lap 56, he was forced to retire due to a drive-shaft problem. It was the first time that Merhi failed to finish a Formula One race that he started, but he remained ahead of Stevens in the Drivers' Championship. In Austria, Merhi finished in 14th position, 3 laps behind race winner Nico Rosberg. Merhi was dropped in favour of Alexander Rossi for five of the last seven Grands Prix of 2015, the exceptions being Russia and Abu Dhabi, before taking a subsequent demotion to Formula E in 2017 and Formula 2 in 2018.