Coached by Riccardo Piatti, Gasquet kicked off his 2012 season by competing at the 2012 Hopman Cup alongside top-10 WTA pro Marion Bartoli. The French won all three of their round-robin ties to reach the final, where they lost to the Czech Republic. Gasquet lost in the quarterfinals in Sydney to Denis Istomin. He competed in the Australian Open shortly afterward, defeating Andreas Seppi, Andrey Golubev, and ninth seed Janko Tipsarević en route to the fourth round. There, he faced and lost to fifth seed David Ferrer. Immediately thereafter, he made the quarterfinals at the Open Sud de France, where he lost to Philipp Kohlschreiber.