The first large-scale use of the CANT Z.1007s took place with the outbreak of the Italian invasion of Greece. During the invasion of Greece, the "Regia Aeronautica" deployed the largest number of CANT Z.1007s. On 28 October 1940, first day of invasion, 47° "Stormo Bombardamento Terrestre" (based on Grottaglie airfield) and 50° "Gruppo" of 50° "Stormo" (based on Brindisi airfield) had on line 44 "Alcione". On 5 November, those units were joined by 41° "Gruppo" of 12° "Stormo", with 16 aircraft. The "Stormi" suffered few losses, among them two made by a PZL P.24, manned by Second Lieutenant Marinos Mitralexis, who managed to bring down one of the two CANT Z.1007s by ramming its tail. During January 1941, 41° Gruppo was replaced by 95° "Gruppo" of 35° "Stormo". It was in this war theatre that the wooden structure of the CANT Z.1007s began to show its weaknesses. The heavy rains damaged it, forcing continuous repairs by the ground crews.