Fabrizio was born sometime before 1452. He was married to Agnese da Montefeltro daughter of Federico da Montefeltro, 1st Duke of Urbino, and Battista Sforza. Fabrizio was known as count of Tagliacozzo and grand constable of the kingdom of Naples. During the Italian War of 1499–1504, he played a notable part in the Battle of Cerignola in 1503. He was a general in the Holy League that fought against Louis XII of France from 1509 to 1515, and at the Battle of Ravenna, he commanded the army of the Papal States against France.