I AM A 37 YEAR OLD FEMALE, MOTHER OF 11 CHILDREN. The youngest is 12 months old. I have always suffered from headaches and about 5 months ago my neurologists place me on Amatriptelene. 2 -10mg tablets at night before bed. It knocked out the headaches, however within 2 weeks I began to gain a lot of weight. At about 6 months postpartum i weighed 160. However in a matter of months, I now weigh 198 lbs. In addition I started feeling very bloated and having pain in the middle of my upper abdomen. As a result my doctor ordered an ultrasound. I received the results this morning....An enlarged spleen and liver. My family history is one that includes my father who suffers from polycythemia vera which has progressed to leukemia. He has an enlarged spleen and liver. My 49 year old brother was diagnosed with stage 4 colon cancer last year that spread to both the liver and lungs. Need less to say, I m a bit concerned. I was under the impression that PV was not hereditary but now I wonder. Also as of this morning I m feeling burning during urination. But all labs showed up no infection anywhere. Do you have any advice as I proceed on this journey?

Summarized question: Can enlarged spleen and liver lead to polycythemia vera?