SUBJECT: family lineage with three types of genetic disorder
MESSAGE: In our family line there are three children with different genetic disorders, i want to know if this is a congenital condition that could affect future offspring in this lineage.  One has downs syndrome, one had wolf herschhorn, and one has 46xy, 46xxy and 46xxxy; together referred to as Mosaic. they are all third cousins, there are many other children who will one day possibly have offspring is there a danger, should each have genetic testing

Summarized question: What are the inheritnce patterns of Downs Syndrome, Wolf Hirschhorn Syndrome, and 46xy, 46xxy, 46xxxy mosaicism?