I have taken enbrel injections and methotrexate for several years.  Are there adverse long-term effects? I have psoriatic arthritis. The meds control the psoriasis but not the arthritis very well. I often wonder if taking these meds is worth future effects.  Most of the time I feel fatigued and very sore.  I also take 4 high blood pressure meds.  I hate taking so many meds, and it's very expensive.  Is there anyone out there who has taken the methotrexate and enbrel injections for any length of time? I would like to know if you have experienced any adverse effects.  I am not interested in switching to humira or remicade b/c my insurance does not cover them.  I am also interested in any feedback from other psoriatic sufferers.

Summarized question: Are there any adverse long-term effects of Enbrel injections and methotrexate?