Has any one on Depo Provera had any side effects? What were they? I was on the depo shot after my first baby in 2001. I later stopped getting them after about 3 years. I actually got pregnant again in late 2004. I was getting the shot again after my second baby was born. Now I have stopped since my husband got a vasectomy. I noticed while on the shot I gained weight. Also my periods were all wacky. I could go 2 months or the whole 3 months without a period. I also had very bad mood swings. I also had absolutly no energy and was tired all the time. I am only 24 years old. After getting off the shot the first time I started to lose some of the weight and my periods returned to normal. Someone in another post mentioned that depo depleets the calcium in your body. I fractured my ankle when I stepped down wrong when I was 8 months pregnant with my 2nd child. Normally the way I twisted my ankle would have caused maybe a sprain. But I cracked the bone. Now I am wondering if the depo provera caused my bones to be more brittle.

Summarized question: What are the side effects of Depo Provera?