Coming off their road win over the Rams, the Bills flew to the University of Phoenix Stadium for a Week 5 interconference game with the Arizona Cardinals.  In the first quarter, Buffalo trailed early as Cardinals QB Kurt Warner completed a 2-yard TD pass to WR Larry Fitzgerald.  In the second quarter, Arizona increased its lead as RB Tim Hightower got a 17-yard TD run.  The Bills responded as QB J.P. Losman completing an 87-yard TD pass to WR Lee Evans, yet the Cardinals replied with RB Edgerrin James getting a 1-yard TD run.  Buffalo answered with Losman's 1-yard TD run, yet Arizona closed out the half with kicker Neil Rackers getting a 47-yard field goal. In the third quarter, the Bills tried to catch up as kicker Rian Lindell got a 48-yard field goal, but the Cardinals answered with Warner completing a 2-yard TD pass to Fitzgerald.  In the fourth quarter, Arizona pulled away as Rackers nailed a 38-yard field goal, along with Hightower getting a 2-yard TD run, With the loss, Buffalo went into their bye week at 4-1. QB Trent Edwards (3/3 for 18 yards), who originally started, was knocked out the game on the Bills' third offensive play by Cardinals safety Adrian Wilson with a concussion.

Question: What was the longest touchdown play of the game?
Answer: 87-yard TD pass

Question: Who caught both Cardinal touchdown passes?
Answer: Larry Fitzgerald

Question: What is the Bills record after the loss?
Answer: 4-1

Question: How long was James touchdown run?
Answer: 1-yard TD run

Question: Which player threw more touchdown passes?
Answer: QB Kurt Warner

Question: In what quarter did both teams score two touchdowns?
Answer: second quarter

Question: What was the longest touchdown play of the game?
Answer: 87-yard TD pass

Question: Which team scored the most in the first two quarters?
Answer: Cardinals

Question: How many touchdowns did Cardinals make before halftime?
Answer: 3

Question: How many field goals did Cardinals make before halftime?
Answer: 1

Question: Who kicked the longest field goal?
Answer: Rian Lindell

Question: Who kicked the longest field goal in the fourth quarter?
Answer: Rackers

Question: Who threw the longest touchdown pass in the first quarter?
Answer: Kurt Warner

Question: Who threw the longest touchdown pass of the game?
Answer: QB J.P. Losman

Question: How many yards longer was the longest field goal Rackers kicked?
Answer: 9

Question: Who threw the longest touchdown pass of the game?
Answer: J.P. Losman

Question: How many yards did Antonio Brown gain on his first two touchdowns scored?
Answer: 81

Question: How many yards longer was Antonio Brown's second touchdown compared to his first?
Answer: 13

Question: How many yards longer was David Akers' first field goal relative to Shaun Suisham's first field goal?
Answer: 10

Question: How many yards were gained on Shaun Suisham's first field goal when combined with David Akers' first field goal?
Answer: 60

Question: How many yards longer was Calvin Johnson's longest touchdown when compared to the longest field goal?
Answer: 44

Question: How many field goals measuring longer than 30 yards were converted?
Answer: 2

Question: Which kicker made the longest field goal of the game?
Answer: David Akers

Question: Which quarterback had the longest passing touchdown of the game?
Answer: Matthew Stafford

Question: Which player scored a passing touchdown measuring longer than 75-yards long?
Answer: Matthew Stafford

Question: Which player caught the shortest touchdown reception of the game?
Answer: Will Johnson

Question: How many points did both teams combine for at the end of the game?
Answer: 61