diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/1-iWE_Sbnvw_postprocess.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/1-iWE_Sbnvw_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..fd4e214b3f8aebb47dff6d74305810cc150a5593
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/1-iWE_Sbnvw_postprocess.srt
@@ -0,0 +1,3996 @@
+1
+00:00:03,500 --> 00:00:10,420
+أيه؟ أين راحت؟ اسمع ليني عشان أعمل share screen
+
+2
+00:00:10,420 --> 00:00:16,820
+share screen طيب
+
+3
+00:00:16,820 --> 00:00:25,200
+بسم الله الرحمن الرحيم بالنسبة
+
+4
+00:00:25,200 --> 00:00:34,630
+لـ إن شاء الله محاضرة اليومراح نتكلم عن يعني
+
+5
+00:00:34,630 --> 00:00:43,310
+تطبيقات في جانب مهم من الأمراض الوراثية والوراثة
+
+6
+00:00:43,310 --> 00:00:50,390
+ومبادئها على الجانب المهم وهو الدم، الـHemoglobin
+
+7
+00:00:50,390 --> 00:00:53,630
+فبالنسبة
+
+8
+00:00:53,630 --> 00:00:59,920
+لكتابكم، احنا بشكل عامما كنت حابب أنه كمبادئ للـ
+
+9
+00:00:59,920 --> 00:01:04,320
+Genetics أنه ندخل في الـ Specific Diseases والـ
+
+10
+00:01:04,320 --> 00:01:09,440
+Specific Conditions بس أحيانًا تضطر عشان تفهم
+
+11
+00:01:09,440 --> 00:01:15,000
+الموضوع تمامًا من ناحية الوراطب في جانب معين ويكون
+
+12
+00:01:15,000 --> 00:01:21,020
+مهم إنك تدرس مثال عليها وتفهم كيف احنا الآن في
+
+13
+00:01:21,020 --> 00:01:28,040
+العصر الحاليوبنربط الجينات
+
+14
+00:01:28,040 --> 00:01:34,480
+بتفاصيلها الدقيقة بالحالات والأمراض ونشوف كيف
+
+15
+00:01:34,480 --> 00:01:41,520
+تنتقل من جين على مستوى الـ DNA لمستوى إنه يكون مرض
+
+16
+00:01:41,520 --> 00:01:46,680
+عند الإنسان بس قبل ما ندخل في المحاضرة وندخل في
+
+17
+00:01:46,680 --> 00:01:50,980
+تفاصيل
+
+18
+00:01:50,980 --> 00:01:58,410
+الأموركنت بدي أبدأ بسؤال اللي اعتقدتمه يعني
+
+19
+00:01:58,410 --> 00:02:06,950
+افترضنا إنه احنا صوّينا الـ
+
+20
+00:02:06,950 --> 00:02:15,630
+AVO type للـ Badge تبعتكم حوالي 151 وشوفنا
+
+21
+00:02:15,630 --> 00:02:20,030
+الـ frequency of the alleles أسف الـ frequency of
+
+22
+00:02:20,030 --> 00:02:24,980
+the typesحطيت أنا النسب هذه صراحة السؤال غلط
+
+23
+00:02:24,980 --> 00:02:31,000
+ومنحلش من ناحية إنه أنا اللي حطيته نسب هيك من رأسي
+
+24
+00:02:31,000 --> 00:02:36,140
+جمعت ان يكونوا 100 وحطيتها هيك يعني وهذا كان سؤال
+
+25
+00:02:36,140 --> 00:02:46,260
+خاطر يعني مش هيك بس الحل الحل كان إن الواحد يمسك
+
+26
+00:02:46,260 --> 00:02:52,260
+في الأشياء القوية الواضحةاللي يعني إلها معلومات
+
+27
+00:02:52,260 --> 00:03:00,740
+مفيدة وفيه صراحة رقمين يعني صحيحه بالنسبة
+
+28
+00:03:00,740 --> 00:03:09,680
+كأرقام نسب حتى تهيكة بذكر فيه معادلتين المعادل
+
+29
+00:03:09,680 --> 00:03:16,260
+الأولى إنه إذا اختردنا عنا Two alleles إذا كانوا
+
+30
+00:03:16,260 --> 00:03:23,940
+في one certain locusإذا المعادلتين طبعته إنه الـP
+
+31
+00:03:23,940 --> 00:03:30,280
+زاد الـQ بساوي 1 والـP تربيع زاد 2PQ زاد Q تربيع
+
+32
+00:03:30,280 --> 00:03:33,600
+بساوي 1 دولة دايماً الرقمين اللي بدنا ندعو
+
+33
+00:03:33,600 --> 00:03:37,720
+معادلتين المهمات عشان واحد في الواحد يدبر حاله
+
+34
+00:03:37,720 --> 00:03:44,480
+فإذا افترضنا إن الـO type 30% الـO type هو
+
+35
+00:03:44,480 --> 00:03:51,120
+الـRecessive وبالتاليحتى يظهر لازم يكون homozygous
+
+36
+00:03:51,120 --> 00:03:57,180
+لازم يكون pure لازم يكون تنتم من الـO فإذا الـQ
+
+37
+00:03:57,180 --> 00:04:01,680
+تربيع بساوي يعني هو أنا بدأ ناخد الـQ تربيع لأن
+
+38
+00:04:01,680 --> 00:04:11,140
+هذه نسبة الـO فبدا تكون 0.3 فالـQ بدا تكون 0.548
+
+39
+00:04:11,140 --> 00:04:18,420
+يعني 55% تقريبًا حتى كجين على مستوى القليلتحيث إنه
+
+40
+00:04:18,420 --> 00:04:25,080
+يكون 30% recessive لهذا الدرجة واضح وبالتالي احنا
+
+41
+00:04:25,080 --> 00:04:33,680
+أنا كان يعني صحيح حصلت اثنين بس يعني الـA والـB
+
+42
+00:04:33,680 --> 00:04:41,480
+المرة هذه يعني مش بس one، one القليل غير الـO
+
+43
+00:04:41,480 --> 00:04:45,940
+الـdominant يعني عندى اثنين dominant الـA والـB
+
+44
+00:04:47,160 --> 00:04:52,120
+وكنت أنا بدي أقول إن الـFrequency تبعتهم اللي هي
+
+45
+00:04:52,120 --> 00:05:01,520
+الـA زي الـB بساوة البقية لأنه راح يكونوا عبارة عن
+
+46
+00:05:01,520 --> 00:05:07,760
+اللي أخدنا معادلة الـB زي الـQ بساوة واحد والـQ
+
+47
+00:05:07,760 --> 00:05:12,920
+طلعت هالقدة، هاي الـB اللي هي الـFrequency تبعت
+
+48
+00:05:12,920 --> 00:05:21,160
+الـA والـBبساوي اللي هو الـ P اللي هي بقيت الواحد
+
+49
+00:05:21,160 --> 00:05:29,260
+فهيكون إن الـ X والـ Y بساوية 0.452 فإن هذه
+
+50
+00:05:29,260 --> 00:05:37,540
+معادلتين ماشي، والنقطة المهمة من النسب اللي احنا
+
+51
+00:05:37,540 --> 00:05:43,620
+حصلنا عليها اللي هو الـ AB الـ AB is codominant
+
+52
+00:05:44,380 --> 00:05:51,280
+يعني الـ «A» ظاهر والـ «B» ظاهر فحتى نشوف نسبة الـ
+
+53
+00:05:51,280 --> 00:05:57,720
+Frequency هذه في الـ Population بدا تكون «X» ضارب
+
+54
+00:05:57,720 --> 00:06:04,120
+«Y» ساوي 26% فصراحة لما جيتنا نفعلنا معادلتين
+
+55
+00:06:04,120 --> 00:06:10,740
+بمجهولين ونقدر بالرياضيات نحلها، هيك الأصل وأنا
+
+56
+00:06:10,740 --> 00:06:15,930
+فكرت أن هيك تقدر بسهولةالواحد يطلّع النسب كلهم
+
+57
+00:06:15,930 --> 00:06:22,090
+ويطبّقها الصراحة طلعت تنحلّش بسبب إن الأرقام مش
+
+58
+00:06:22,090 --> 00:06:27,730
+مظبوطة يعني مافيش أرقام بتحقق هذه النسب بهذه
+
+59
+00:06:27,730 --> 00:06:36,530
+الطريقة بشكل سليم فبعتذر عن المثال كان شوية مستعجل
+
+60
+00:06:36,530 --> 00:06:44,710
+وكان يعني بيكفي الواحد من هدولة النسبتيناللي هو
+
+61
+00:06:44,710 --> 00:06:51,070
+يعني الـ O بشكل واضح والـ A وD بشكل واضح الواحد
+
+62
+00:06:51,070 --> 00:06:58,250
+كان ممكن يطلع كل الأرقام والأصل أنه كان أنا طلعت
+
+63
+00:06:58,250 --> 00:07:03,550
+الإجابات وحطيت شو هي النسب وأعطيتكم إياها عشان
+
+64
+00:07:03,550 --> 00:07:10,770
+تحلوهم بس أتوقع يعني كـ Exercise الواحد بده يشوف
+
+65
+00:07:10,770 --> 00:07:18,830
+لما يقرأ والواحدطلابكم، أحد زملائكم ذكر إنه هو
+
+66
+00:07:18,830 --> 00:07:25,130
+اتطلع على study وشاف فيها النسب وكيف كانت طلعوهم
+
+67
+00:07:25,130 --> 00:07:31,290
+وكذا، بس بتكون من هذا المبدأ، في أسئلة؟ أو في أحد
+
+68
+00:07:31,290 --> 00:07:37,390
+عنده أسئلة حتى عن الامتحان أو عن دكتور
+
+69
+00:07:37,390 --> 00:07:44,540
+أحمد، أنا عادة بالنسبة للامتحاناتبحط جزء من سواء
+
+70
+00:07:44,540 --> 00:07:50,020
+المحاضرة أو إذا كان الناس بيسموه الـ OSCE و الـ
+
+71
+00:07:50,020 --> 00:07:56,360
+Mini OSCE وكذا بحط إنه نجاوب الأسئلة يعني ماعندي
+
+72
+00:07:56,360 --> 00:08:04,100
+مشكلة إنه جزء من المحاضرة الجاية بحط الأسئلة و
+
+73
+00:08:04,100 --> 00:08:09,660
+نقرأ شو الإجابات كانت حتى الواحد ينتبهفي أسئلة قبل
+
+74
+00:08:09,660 --> 00:08:22,060
+ما نبدأ يا شباب ويا دكتورات الأسئلة
+
+75
+00:08:22,060 --> 00:08:27,020
+المعتادة يعني بيسألوا قاعدين عن النصفي في أي شبات
+
+76
+00:08:27,020 --> 00:08:31,240
+اللي راح يكون أما الأمور الامتحانات وترتيبها ما
+
+77
+00:08:31,240 --> 00:08:34,160
+بدناها هنا سبب نسأل الـ Genetics حد عنده سؤال في
+
+78
+00:08:34,160 --> 00:08:34,820
+الـ Genetics
+
+79
+00:08:48,290 --> 00:08:57,910
+أذا خلّينا نبدأ بمحاضرة اليوم اللي هي يعني بدأ
+
+80
+00:08:57,910 --> 00:09:01,490
+ندخل الـ Molecular Basis of Genetic Diseases
+
+81
+00:09:01,490 --> 00:09:08,470
+الفكرة
+
+82
+00:09:08,470 --> 00:09:15,270
+هنا إنه إحناالإنسان إذا باعتبر إن الله سبحانه
+
+83
+00:09:15,270 --> 00:09:23,450
+وتعالى خلقه في أحسن تقويم بطريقة مصبوطة بأحسن
+
+84
+00:09:23,450 --> 00:09:30,090
+تقويم لما تصير mutation كيف الـ mutation هذه تتحول
+
+85
+00:09:30,090 --> 00:09:36,450
+إلى إنه الـ mutation
+
+86
+00:09:36,450 --> 00:09:40,630
+هذه أو الطقرة هذه في الـ DNA تتحول إنها تكون مرضى
+
+87
+00:09:41,040 --> 00:09:45,780
+تكون Disease فالمبدأ
+
+88
+00:09:45,780 --> 00:09:55,000
+الأساسي وهو الـ Graph أو الـ Figure فيه
+
+89
+00:09:55,000 --> 00:10:02,180
+يعني مبادئ أساسية ورح نخدها بطريقة ثانية اللي هي
+
+90
+00:10:02,180 --> 00:10:10,180
+Table بهذا الشكل على طريقة تأثير
+
+91
+00:10:10,670 --> 00:10:16,990
+الـ «طفرة» أو الـ mutation على إنها اتسبب المرض
+
+92
+00:10:16,990 --> 00:10:24,470
+النقطة الأولى، بدل واحد يتذكر إنه «الطفرة» هذه قد
+
+93
+00:10:24,470 --> 00:10:30,910
+تكون باحتمالين إنها تعمل mutation in the coding
+
+94
+00:10:30,910 --> 00:10:35,590
+region يعني في المنطقة المسئولة تماماً عن البروتين
+
+95
+00:10:35,590 --> 00:10:45,340
+اللي ناتج عن الجين هذاأو إنها تفرق في جوانب أخرى
+
+96
+00:10:45,340 --> 00:10:50,700
+اللي هي التحكم في إنتاج البروتين بحيث إنه بالأخير
+
+97
+00:10:50,700 --> 00:10:56,380
+الـ protein structure is normal بس الـ gene
+
+98
+00:10:56,380 --> 00:11:05,850
+regulationالـ Dosage تبع البروتين اللي
+
+99
+00:11:05,850 --> 00:11:11,590
+قد يكون نتيجة يعني بتذكر الواحد إن الـSnips هدولة
+
+100
+00:11:11,590 --> 00:11:15,890
+Single Nucleotide Polymorphism اللي هم Very Common
+
+101
+00:11:15,890 --> 00:11:20,870
+اللي هي تقريبًا في أي إنسان من خمس إلى عشر ملايين
+
+102
+00:11:20,870 --> 00:11:27,720
+Snips موجودة عنده كثير منهم ما بيغيروا البروتينما
+
+103
+00:11:27,720 --> 00:11:31,420
+بيغيروه، يعني بيكون بالأخير هاي الـSnip إحنا
+
+104
+00:11:31,420 --> 00:11:35,900
+نستفيد منها في التشخيص أحيانًا في الـMarkers وكده
+
+105
+00:11:35,900 --> 00:11:42,520
+بس هي حقيقةً لا تؤثر في الوظيفة ففي ميوتاشن، بدنا
+
+106
+00:11:42,520 --> 00:11:48,740
+نفرقكم، إشي تكون في الـCoding Region بالتالي
+
+107
+00:11:48,740 --> 00:11:56,360
+بيعطينا Abnormal Proteins أو في الـRegulationتبع
+
+108
+00:11:56,360 --> 00:12:00,640
+الـ Gene Expression في حياته إنه بيصير عندي ولو إن
+
+109
+00:12:00,640 --> 00:12:05,860
+الـ Protein Structure is normal بس الكمية أو الـ
+
+110
+00:12:05,860 --> 00:12:11,020
+Function من ناحية أخرى بتكون Abnormal النقطة
+
+111
+00:12:11,020 --> 00:12:19,080
+الثانية إنه في أحيانًا الـGenetic Diseases اللي
+
+112
+00:12:19,080 --> 00:12:26,620
+بتأثر بالمحصلة على الـRNA Level يعني هناعلى الـ
+
+113
+00:12:26,620 --> 00:12:31,600
+Mutations Disturbing الـ RNA Stability يعني هاي
+
+114
+00:12:31,600 --> 00:12:37,100
+برضه جانب آخر مش دايماً أي Disease Genetic Disease
+
+115
+00:12:37,100 --> 00:12:44,740
+بلاقي إنه في الأخير فيه يعني عندي الـ DNA هو اللي
+
+116
+00:12:44,740 --> 00:12:48,760
+فيه المشكلة أحياناً بتصير أمراض نتيجة إن الـ RNA
+
+117
+00:12:48,760 --> 00:12:54,500
+بعد ما يصير Transcription بيصير عليه مشاكل ف
+
+118
+00:12:56,960 --> 00:13:05,120
+الحالات الأولى لما نكون الـ mutation أو الطفرة في
+
+119
+00:13:05,120 --> 00:13:11,240
+الـ coding DNA اللي هي مباجرة مسئولة عن الـ
+
+120
+00:13:11,240 --> 00:13:16,840
+protein abnormality اللي هي هنا فلما نكون عندنا
+
+121
+00:13:16,840 --> 00:13:22,340
+protein abnormality ممكنإذا عندها Unstable
+
+122
+00:13:22,340 --> 00:13:31,780
+Decreased Amount وهنا عبارة عن Hemoglobin نوعية
+
+123
+00:13:31,780 --> 00:13:35,580
+خاصة اللي هو Hammersmith اللي هو اسم المستشفى
+
+124
+00:13:35,580 --> 00:13:41,020
+ببريطانيا اللي اكتشفوا الـ Hemoglobin هذا عنده
+
+125
+00:13:41,020 --> 00:13:48,760
+فسموه بهذا الاسم نوعي معين ممكن أنه يكون عندي اللي
+
+126
+00:13:48,760 --> 00:13:55,570
+هي أنهالـ Loss of the protein function إنه أنا
+
+127
+00:13:55,570 --> 00:14:01,810
+أخبط للبروتين لأنه abnormal صار في عندي Loss of
+
+128
+00:14:01,810 --> 00:14:06,290
+the function أو إنه gain of functions أحياناً
+
+129
+00:14:06,290 --> 00:14:12,390
+بيكون أقوى من اللازم زي راح نأخد مثال على اللي هي
+
+130
+00:14:12,390 --> 00:14:17,690
+higher مثلاً
+
+131
+00:14:17,690 --> 00:14:24,200
+Oxygen affinity للهيمoglobinفزادت وظيفة، يعني ماسك
+
+132
+00:14:24,200 --> 00:14:27,980
+الـ Hemoglobin بالأكسجين كتير فصار الـ Endogenous
+
+133
+00:14:27,980 --> 00:14:34,940
+Function أو Noble Property يعني صفة مختلفة وجديدة
+
+134
+00:14:34,940 --> 00:14:40,600
+تماماً نتيجة الخلل اللي صار زي في حالات الـ Sickle
+
+135
+00:14:40,600 --> 00:14:44,280
+Cell Anemia الـ Sickle Cell Hemoglobin اللي هو
+
+136
+00:14:44,280 --> 00:14:48,780
+بيسموه Hemoglobin S اللي هو بيصير إنهلمّا ينقص
+
+137
+00:14:48,780 --> 00:14:53,760
+الأكسجين يصير الـ Clumping of the Hemoglobin
+
+138
+00:14:53,760 --> 00:15:01,040
+موليكيول يصير عندي Cycling ويصير عندي Disease فهذه
+
+139
+00:15:01,040 --> 00:15:05,700
+هي ميكانيزم للمرض لما يكون عندي protein abnormal
+
+140
+00:15:05,700 --> 00:15:13,640
+يعني المرض نتيجة سواء زيادة الـ Function قلة الـ
+
+141
+00:15:13,640 --> 00:15:20,390
+Function قلة البروتينأو وظيفة جديدة تماماً، ملاحظة
+
+142
+00:15:20,390 --> 00:15:28,430
+جديدة تماماً فالـ Protein abnormality بيكون
+
+143
+00:15:28,430 --> 00:15:33,110
+through multiple mechanisms leading to the disease
+
+144
+00:15:33,110 --> 00:15:38,910
+ممكن الـ Protein structure is normal بس الـ
+
+145
+00:15:38,910 --> 00:15:43,610
+mutation في الـ control فبتأثر على الـ dosage أو
+
+146
+00:15:43,610 --> 00:15:49,930
+level of the expressionفـ Decreased amount زي
+
+147
+00:15:49,930 --> 00:15:56,690
+التلاثيميا راح ناخد أنواع التلاثيميا وشو المنوعة
+
+148
+00:15:56,690 --> 00:16:01,170
+بس كمان يعني هذه الـ Abnormal Structure أو الـ
+
+149
+00:16:01,170 --> 00:16:04,810
+Function هو أنا Abnormal Function حتى في الـ Tumor
+
+150
+00:16:04,810 --> 00:16:08,730
+Suppressor Mutations بتؤدي للـ Loss of Function
+
+151
+00:16:08,730 --> 00:16:16,610
+بتلاقيها بعدين في عنديفي عندي diseases نتيجة
+
+152
+00:16:16,610 --> 00:16:21,290
+الغناط بمعنى الـ Cancer الـ Increased amount بيصير
+
+153
+00:16:21,290 --> 00:16:28,370
+لنا gain of function مثلًا Trisomy أي عبارة عن لما
+
+154
+00:16:28,370 --> 00:16:37,210
+نكون زي ما خدنا مثلًا Trisomy 21 وبالتالييعني
+
+155
+00:16:37,210 --> 00:16:42,690
+الأصل أنه فيه زيادة في level of the proteins لأنه
+
+156
+00:16:42,690 --> 00:16:46,370
+الجينات صارت أكتر فيه مرض اسمه «Charcot-Marie
+
+157
+00:16:46,370 --> 00:16:53,430
+-Tooth Type-A» تبارك عن مرض عصبي بيصير فيه ضعف
+
+158
+00:16:53,430 --> 00:17:03,610
+العضلات وضعف العصاب وهنا بتكون يعني فيه نوع من الـ
+
+159
+00:17:04,720 --> 00:17:09,700
+«Controller» جين معين بيصير عندي زيادة وبقى ضمن
+
+160
+00:17:09,700 --> 00:17:13,940
+إنه يتظامن فيه أنواع X-linked وفيه تظامن dominant
+
+161
+00:17:13,940 --> 00:17:23,700
+وفيه له أنواع مش مهمة كتير وفي عندنا اللي هي topic
+
+162
+00:17:23,700 --> 00:17:28,840
+or heterochronic expression راح نعطي أمثلة عنها
+
+163
+00:17:28,840 --> 00:17:34,970
+ويعني اللي هي إنهالأصل إنه فيه جينات بتشتغل وفيه
+
+164
+00:17:34,970 --> 00:17:39,970
+جينات ساكتة في كل مرحلة من حياة الإنسان بتلاقي
+
+165
+00:17:39,970 --> 00:17:44,430
+مفروض جينات معينة هي بتشتغل وبعدين الأشياء التانية
+
+166
+00:17:44,430 --> 00:17:50,850
+بتصير اتوقف فإذا صار إنه الشغل والتوقيف مش مظبوط،
+
+167
+00:17:50,850 --> 00:17:54,430
+ماشي تصير عندي inappropriate expression and wrong
+
+168
+00:17:54,430 --> 00:17:59,690
+time or place كانت سبب للـDisease أنا بعتبر يعني
+
+169
+00:17:59,690 --> 00:18:08,410
+كمبادئلقضية إيش اللي بيخرب وإيش كيف من الانتقال من
+
+170
+00:18:08,410 --> 00:18:11,730
+الـMutation لـDisease وليش بيكون الـDisease بهذا
+
+171
+00:18:11,730 --> 00:18:19,610
+الشكل بدا تكون يعني نتيجة خلل بأحد هذه الطرق بأحد
+
+172
+00:18:19,610 --> 00:18:28,150
+هذه الـMechanism لما ناخد يعني الـA باعتبروها الـ8
+
+173
+00:18:28,150 --> 00:18:32,860
+Stepsبالنسبة للميوتاشيون التي يمكنها تغيير نشاط
+
+174
+00:18:32,860 --> 00:18:40,540
+البروتين العادل يعني هنا بيحاولوا يعطوكم كل أنواع
+
+175
+00:18:40,540 --> 00:18:50,060
+الخلل اللي بتأدي من المرض أو الـ mutation بحيث أنه
+
+176
+00:18:50,060 --> 00:18:58,380
+يعني كانت بنتج عن الـ mutation لتوصل إلى تسبب
+
+177
+00:18:58,380 --> 00:19:07,450
+المرضالآن ممكن المشكلة تكون «at the stage» أو «at
+
+178
+00:19:07,450 --> 00:19:14,890
+the transcription» بطرحكم مثلًا الفلسينيا يعني
+
+179
+00:19:14,890 --> 00:19:22,310
+إحنا من البداية إذا في أسئلة وقفوني ما تخلونيش
+
+180
+00:19:22,310 --> 00:19:28,030
+أكمل إذا في إيش مش واضحأنا من الأهم أشياء اللي بحب
+
+181
+00:19:28,030 --> 00:19:36,650
+أركز عليها قضية المبادئ يعني مثلاً لما نقول سرطان
+
+182
+00:19:36,650 --> 00:19:44,370
+دم خلايا الدم وتكون في العقد الليمفاوي فقط بنسميه
+
+183
+00:19:44,370 --> 00:19:52,150
+lymphoma إذا بتكون وصل جوا خلايا أو وصل جوا الدم
+
+184
+00:19:52,760 --> 00:19:57,440
+يعني صارت الخلايا السرطانية جوا الدم نفسه فبنسميه
+
+185
+00:19:57,440 --> 00:20:00,980
+Leukemia فالـ Leukemia والـ Lymphoma هم نفس
+
+186
+00:20:00,980 --> 00:20:09,600
+السرطان نفس الخلايا وأحياناً بتلاقوا أنه الأمور
+
+187
+00:20:09,600 --> 00:20:13,980
+مشتبهة فهي أنا بهمني يعني من اللي بركز للدكاترة
+
+188
+00:20:13,980 --> 00:20:19,380
+والطلاب الطب أنه الواحد يفرق بين الـ Leukemia والـ
+
+189
+00:20:19,380 --> 00:20:23,810
+Lymphoma هذه المبدأ يعني فاحناالـ
+
+190
+00:20:23,810 --> 00:20:30,230
+hemoglobinopathies الـ diseases كلها تمجموعة تنقسم
+
+191
+00:20:30,230 --> 00:20:35,690
+لثلاث أنواع أو حطوها ثلاث أنواع هنا في إيش اسمه
+
+192
+00:20:35,690 --> 00:20:42,350
+ثلاثينية يعني إحنا بنقسم الـ hemoglobinopathies زي
+
+193
+00:20:42,350 --> 00:20:46,170
+ما بيقولوا quantitative و qualitative في مشكلة في
+
+194
+00:20:46,170 --> 00:20:55,770
+الكمية وفي مشكلة في الوظيفة والنوعية إذاالكمية تبع
+
+195
+00:20:55,770 --> 00:20:59,730
+الـ Hemoglobin نحن نسميه تلاثينيا فتلاثينيا هي
+
+196
+00:20:59,730 --> 00:21:03,230
+quantitative Hemoglobin Hepatocyte يمكن أن يكون
+
+197
+00:21:03,230 --> 00:21:09,570
+فيه مشكلة في عدد أو كمية الـ Hemoglobin ويكون فيه
+
+198
+00:21:09,570 --> 00:21:16,390
+مشكلة بالنسبة لها فالـ High نحن نسميها تلاثينيا
+
+199
+00:21:16,390 --> 00:21:22,730
+وفي الـ Quantitative اللي يعني أنهنفس البروتين فيه
+
+200
+00:21:22,730 --> 00:21:28,130
+مشكلة، فيه غلط، فيه مرض، فيه إشي هاي بدنا نسميها
+
+201
+00:21:28,130 --> 00:21:32,770
+زي الـ Sickle Cell Anemia الـ Sickle Cell اللي هي
+
+202
+00:21:32,770 --> 00:21:38,810
+راح ناخد الأنيميا المنجالية هذه بتكون مشكلة
+
+203
+00:21:38,810 --> 00:21:45,170
+بالنسبة للـ Type of Hemoglobin نفسه، مش الكمية
+
+204
+00:21:45,170 --> 00:21:50,370
+تبعته، النوعية تبعته وفي نوع أخر اعتبروه اللي هو
+
+205
+00:21:50,870 --> 00:21:59,270
+الـ يعني اللي هو gain of function زي persistence
+
+206
+00:21:59,270 --> 00:22:04,990
+of hemoglobin ويكون higher affinity for the oxygen
+
+207
+00:22:04,990 --> 00:22:12,910
+الآن الـ eight steps كيف الـ mutation بتتحول ل
+
+208
+00:22:12,910 --> 00:22:16,890
+disease causing it can be at the level of the
+
+209
+00:22:16,890 --> 00:22:23,700
+transcription فمثلا التلسيميايا إما الـDeletion of
+
+210
+00:22:23,700 --> 00:22:32,680
+the gene itself أو Absent Production of the
+
+211
+00:22:32,680 --> 00:22:38,920
+Globulin Messenger RNA أو Deletions أو Mutations
+
+212
+00:22:38,920 --> 00:22:42,280
+in the Regularity أو Supply Sites of the Globulin
+
+213
+00:22:42,280 --> 00:22:49,000
+gene يعني بطريقة ما عبارة عن هنا Decrease
+
+214
+00:22:51,690 --> 00:22:57,150
+«ترانسكрипشن» من تلك الجينة «Herditary Persistence
+
+215
+00:22:57,150 --> 00:23:04,650
+of Fetal Hemoglobin» هذه النوعية خللت بطريقة أخرى
+
+216
+00:23:04,650 --> 00:23:11,930
+إنه فيه إشي كان موجود الأصل إنه يكون مش موجود يعني
+
+217
+00:23:11,930 --> 00:23:17,130
+إن هذا كان الأصل إنه ما يكونش موجودبس إنه يظل بعد
+
+218
+00:23:17,130 --> 00:23:24,350
+الوقت المناسب له هذا يعني تسبب للمرض الـ
+
+219
+00:23:24,350 --> 00:23:30,390
+Translation اللي هي تحويل الـ RNA إلى البروتين
+
+220
+00:23:30,390 --> 00:23:39,890
+قولتت بتاع الـGene فما أيه برضه ممكن نتيجة يعني
+
+221
+00:23:39,890 --> 00:23:46,890
+مثال على الـ Thalassemia واللي هون حكوهميكانيزم أو
+
+222
+00:23:46,890 --> 00:23:53,310
+ممكن أن يكون هناك ميكانيزمات باثوجينيتيك أو ممكن
+
+223
+00:23:53,310 --> 00:23:54,330
+أن يكون هناك ميكانيزمات باثوجينيتيك أو ممكن أن
+
+224
+00:23:54,330 --> 00:23:54,830
+يكون هناك ميكانيزمات باثوجينيتيك أو ممكن أن يكون
+
+225
+00:23:54,830 --> 00:23:55,630
+هناك ميكانيزمات باثوجينيتيك أو ممكن أن يكون هناك
+
+226
+00:23:55,630 --> 00:24:00,890
+ميكانيزمات باثوجينيتيك أو ممكن أن يكون هناك
+
+227
+00:24:00,890 --> 00:24:03,570
+ميكانيزمات باثوجينيتيك أو ممكن أن يكون هناك
+
+228
+00:24:03,570 --> 00:24:04,990
+ميكانيزمات باثوجينيتيك أو ممكن أن يكون هناك
+
+229
+00:24:04,990 --> 00:24:09,370
+ميكانيزمات باثوجينيتيك أو ممكن أن يكون هناك
+
+230
+00:24:09,370 --> 00:24:16,790
+ميكانيزمات باثوجينيتيك أو مالـ ما نقول شو هما الـ
+
+231
+00:24:16,790 --> 00:24:19,670
+الـ Amino Acids اللي هو اسمه الـ Primary Structure
+
+232
+00:24:19,670 --> 00:24:23,630
+بعدين كنا بتحول لSecondary Structure تارشير
+
+233
+00:24:23,630 --> 00:24:29,950
+Structure لQuaternal Structure التشكل الرابعي
+
+234
+00:24:29,950 --> 00:24:39,230
+للبروتين فالـ Folding الأول هو الـ Secondary
+
+235
+00:24:39,230 --> 00:24:42,450
+Structureالـ Amino Acid Sequence و الـ Primary
+
+236
+00:24:42,450 --> 00:24:46,510
+Structure الـ Folding و الـ Relationship Between
+
+237
+00:24:46,510 --> 00:24:53,210
+Nearby Amino Acids بيسموه الـ Secondary Structure
+
+238
+00:24:53,210 --> 00:24:58,290
+وبتكون نتيجة أنه بعد ما تولنا الـ Amino Acid Chain
+
+239
+00:24:58,290 --> 00:25:02,410
+لازم تتلف وتعمل الأشياء اللي لازم تتعملها
+
+240
+00:25:02,410 --> 00:25:07,420
+فبقولولكم هنا More than 70%والـ Hemoglobinopaties
+
+241
+00:25:07,420 --> 00:25:10,940
+هم بسبب همogloبين غير عادلين مع تغيير الـ Amino
+
+242
+00:25:10,940 --> 00:25:18,600
+Acid زي الـ Hemoglobin Hammersmith وبعدين في عندي
+
+243
+00:25:18,600 --> 00:25:24,220
+Post-Translational Modification يعني مثلًا بعد ما
+
+244
+00:25:24,220 --> 00:25:28,840
+يخلص البروتين ويصير يعمل Goldie الأصل إن أنا أصير
+
+245
+00:25:28,840 --> 00:25:34,460
+مثلًا في أماكن معينة أحط Glucose أو Carbohydrate
+
+246
+00:25:43,120 --> 00:25:49,100
+بعض الأمراض، وسيضعون عليها مثلًا «مانوز سيكس
+
+247
+00:25:49,100 --> 00:25:57,240
+فوسفات» إبارة عن «مانوز» يعني سكر الموز بيكون معاه
+
+248
+00:25:57,240 --> 00:26:02,820
+فوسفات تنضج في مكان معين ضروري عشان الـ lysodomal
+
+249
+00:26:02,820 --> 00:26:10,160
+storageوبالتالي بيسبب Disease يعني هنا المشكلة في
+
+250
+00:26:10,160 --> 00:26:15,360
+step post-translational بعد ما كوّننا الـVolume
+
+251
+00:26:15,360 --> 00:26:18,420
+بتاعي وصار لها الـFolding الأصل يكون Modification
+
+252
+00:26:18,420 --> 00:26:23,040
+معينة ما بيصير بعدين
+
+253
+00:26:23,040 --> 00:26:32,300
+طبعاً الـTertiary Structure اللي هو الشكل الأخير
+
+254
+00:26:32,300 --> 00:26:40,030
+تبع البروتينبعد ما يكون في عنا يعني interaction
+
+255
+00:26:40,030 --> 00:26:46,110
+between amino acids which are separate يعني الـ
+
+256
+00:26:46,110 --> 00:26:50,290
+secondary structure اللي هو الـ Alpha Helix أو الـ
+
+257
+00:26:50,290 --> 00:26:56,170
+Beta Bleated Sheets هدولة بيكونوا مع الـ يعني
+
+258
+00:26:56,170 --> 00:26:59,630
+interaction between nearby amino acids كل واحد مع
+
+259
+00:26:59,630 --> 00:27:04,890
+اللي بجاره كيف بيترابط بطريقة مختلفةاللي لما يكون
+
+260
+00:27:04,890 --> 00:27:10,370
+الـ Amino Acid بعيدة وترتبط بالذات بالـ disulphide
+
+261
+00:27:10,370 --> 00:27:18,590
+bond بين الـ cytosine أماينو أسد ريزيوز بعيدة عن
+
+262
+00:27:18,590 --> 00:27:23,690
+بعض وتشبك مع بعض هذه بدنا نعتبرها tertial
+
+263
+00:27:23,690 --> 00:27:28,730
+structure وبالتالي assembly of monomers into
+
+264
+00:27:28,730 --> 00:27:34,780
+holomeric protein أحيانًازي وطبعاً هنا يعني
+
+265
+00:27:34,780 --> 00:27:42,520
+تعتبروها أنه التلت أو الـ Interaction يكون بين نسخ
+
+266
+00:27:42,520 --> 00:27:47,300
+متشابهة تماماً من الـ Bollywood بتاع الـ Chairs زي
+
+267
+00:27:47,300 --> 00:27:51,660
+الـ Collagen Triple Helix إذا بتتركوا Structure
+
+268
+00:27:51,660 --> 00:27:55,420
+تبع الـ Collagen فطبعاً الأمراض اللي بيكون فيها
+
+269
+00:27:55,420 --> 00:28:00,760
+Collagen Disease زي مثلاًمعرفة عن سيندروم
+
+270
+00:28:00,760 --> 00:28:06,300
+أهلردانلوس سيندروم أشياء زي هيك بتكون البروتين
+
+271
+00:28:06,300 --> 00:28:14,180
+شكله ويكون انه كل الجين اللي هو من تلت جدائل
+
+272
+00:28:14,180 --> 00:28:19,400
+مربوطات مع بعض في أحيانًا subcellular localization
+
+273
+00:28:19,400 --> 00:28:24,200
+of a polypeptide أو a holomer يعني زي الـfamily
+
+274
+00:28:24,200 --> 00:28:29,750
+الـhypercholesteric mutation مثلًاوين البروتين هذا
+
+275
+00:28:29,750 --> 00:28:34,310
+يعرف في القليل وين يقول هذا برضه أحيانًا بيكون فيه
+
+276
+00:28:34,310 --> 00:28:38,730
+defect Co-factor or prostatic group of binding to
+
+277
+00:28:38,730 --> 00:28:42,790
+a polypeptide يعني أحيانًا حتى يشتغل بالذات
+
+278
+00:28:42,790 --> 00:28:50,310
+الإنزيمات بدنا Co-factor الـ Polypeptide chain
+
+279
+00:28:50,310 --> 00:28:59,350
+يسموها الـ enzyme donorوالـ Apoenzyme أو اللي هو
+
+280
+00:28:59,350 --> 00:29:03,970
+الـ الـ small أو الـ cofactor بيكون هو الإشي
+
+281
+00:29:03,970 --> 00:29:10,790
+الصغير المطلوب عشان كل أنزايم أو بروتين يشتغل
+
+282
+00:29:10,790 --> 00:29:18,590
+أحياناً الـ mutation بتضرب هذا الـ interaction بين
+
+283
+00:29:18,590 --> 00:29:25,440
+الـ الـ quality بتاع الـ chain معالـ Co-Factor
+
+284
+00:29:25,440 --> 00:29:29,220
+المطلوب يعني
+
+285
+00:29:29,220 --> 00:29:32,360
+النتال
+
+286
+00:29:32,360 --> 00:29:38,860
+الأخير اللي هو زي الـ Sickle Cell ماشي أو غيره
+
+287
+00:29:38,860 --> 00:29:45,260
+كمسي كمسي هيمoglobin يكون أن الـ Function زادت
+
+288
+00:29:45,260 --> 00:29:50,720
+نتيجة أن البروتين
+
+289
+00:29:50,720 --> 00:29:58,790
+زاد في الـ Amountأو شغله صار أقوى وأكثر من ما هو
+
+290
+00:29:58,790 --> 00:30:06,910
+مطلوب راح نأخد أمثلة عليها فهدولة الأمثلة على كيف
+
+291
+00:30:06,910 --> 00:30:15,730
+بنحول أو يعني الأنواع التمانية من التأثيرات يا إما
+
+292
+00:30:15,730 --> 00:30:19,170
+الـMutation بتأثر على الـTranscription أو
+
+293
+00:30:19,170 --> 00:30:24,120
+Translation أو على الـFoldingأو على الـ Post
+
+294
+00:30:24,120 --> 00:30:29,240
+-Translational Modification أو على الـAssembly of
+
+295
+00:30:29,240 --> 00:30:35,180
+the monomers into holomers أو الـSubcellular يعني
+
+296
+00:30:35,180 --> 00:30:39,020
+الـMore Advanced Points about الـFunction of the
+
+297
+00:30:39,020 --> 00:30:43,700
+Protein اللي هي الـSubcellular Localization أو
+
+298
+00:30:43,700 --> 00:30:47,900
+الـInteraction مع الـCore Factor أو إنه يصير اندي
+
+299
+00:30:47,900 --> 00:30:53,940
+زيادة أو تغيير الـFunctionبشكل مختلف تماماً كوظيفة
+
+300
+00:30:53,940 --> 00:30:58,960
+مثال على ذلك الـ Sick and Sick راح نحكي عنه في
+
+301
+00:30:58,960 --> 00:31:05,020
+سؤال اتفضلي
+
+302
+00:31:05,020 --> 00:31:13,460
+يا سعاد شو دكتور أحمد؟ خلي سعاد تحكي الله عفوك يا
+
+303
+00:31:13,460 --> 00:31:18,350
+دكتور الله عفوكأول إشي بدي أسأله إنه إحنا حكينا
+
+304
+00:31:18,350 --> 00:31:22,190
+بما إنه فيه 70% من الـMutations الخاصة بالموضوع
+
+305
+00:31:22,190 --> 00:31:26,170
+هذا اللي هي الـNormal in Britain متعلقة بالـBlood
+
+306
+00:31:26,170 --> 00:31:28,670
+عشان هيك أنت الأمثلة اللي ضربتها كلها علاقة
+
+307
+00:31:28,670 --> 00:31:36,690
+بالـBlood لأ، افهمي علينا إحنا اللي حكيناها إحنا
+
+308
+00:31:36,690 --> 00:31:44,370
+اليوم بدنا ندرس كيف الـMutation تتحول لـDisease،
+
+309
+00:31:44,370 --> 00:31:50,460
+ماشي؟فالـ Chapter هذا بالذات المرة هذه مركزين على
+
+310
+00:31:50,460 --> 00:31:54,680
+الدم والأمراض التانية والمشاكل التانية حاطينها في
+
+311
+00:31:54,680 --> 00:31:58,540
+الـ Chapter اللي راح نطلعه بعد دكتوراه فبالنسبة
+
+312
+00:31:58,540 --> 00:32:04,300
+للدم يعني مثلا لو سألتي فصائل الدم كام واحد كام
+
+313
+00:32:04,300 --> 00:32:11,440
+نوع إحنا اللي بتعرفوه الـ ABO و الـ Rh صح؟ صح؟
+
+314
+00:32:11,440 --> 00:32:15,900
+الشيخ اللي بتعرفه الغالب؟في حوالي 600 نوع Blood
+
+315
+00:32:15,900 --> 00:32:21,980
+Groups في 600 نوع من الـ Blood Groups دولة الأشياء
+
+316
+00:32:21,980 --> 00:32:25,820
+اللي بنسميه Blood Group لسه في أنواع كثيرة وكل
+
+317
+00:32:25,820 --> 00:32:30,820
+واحد يمكن أشياء نادرة جدا بس موجودة في هذه الكتب
+
+318
+00:32:30,820 --> 00:32:34,280
+وإذا الواحد بدي تعامل مع المرضى والناس والمجتمع
+
+319
+00:32:34,280 --> 00:32:37,640
+بدي أكون هيك على انتباه إنه فيه إشي اسمه Blood
+
+320
+00:32:37,640 --> 00:32:42,740
+Groups مختلفة الآن أنواع الـ Hemoglobin Obesity
+
+321
+00:32:43,540 --> 00:32:52,060
+كـGenetic Diseases كأمراض دم وراثية مش أمراض دم من
+
+322
+00:32:52,060 --> 00:32:58,180
+أنواع تانية يعني نتيجة Cancer، نتيجة Nutritional
+
+323
+00:32:58,180 --> 00:33:02,480
+Deficiency، نتيجة Autoimmune Disease، مش
+
+324
+00:33:02,480 --> 00:33:06,240
+الـPathologies التانية، احنا بنحكي الـGenetic الآن
+
+325
+00:33:06,240 --> 00:33:10,360
+بتبسمهم زي ما حكينا فيه Quantitative
+
+326
+00:33:10,360 --> 00:33:13,120
+وQualitative……………………………………………………………………………………………………………………………………………………………………�
+
+327
+00:33:13,410 --> 00:33:19,410
+Blood Disease فالآن الـ من يعني الآن حتى لما نقول
+
+328
+00:33:19,410 --> 00:33:23,830
+ثلاثيميا أو Sickle Cell هدولة Big Groups ويلهن
+
+329
+00:33:23,830 --> 00:33:29,690
+أشكال وأنواع وأنواع وفي لسه في أنواع أمراض Under
+
+330
+00:33:29,690 --> 00:33:35,210
+ومش مطلوب إنك تعرفها بس على الـ Bolivar Tide
+
+331
+00:33:35,210 --> 00:33:40,110
+Folding في سبعين Hemoglobinopathy تانية كمان
+
+332
+00:33:40,110 --> 00:33:48,040
+مابدناش ندخل فيهمبس كثير منهم لها علاقة بتلوى الـ
+
+333
+00:33:48,040 --> 00:33:52,340
+«Globule Polypeptide Chain» اللي هو الـ «Holding»
+
+334
+00:33:52,340 --> 00:33:57,120
+أغلبها كانوا «Holding» أه، ماشي طيب، دكتور، إحنا
+
+335
+00:33:57,120 --> 00:34:00,140
+مطالب مثلا معناه نعرف أنه نوع من الـ «ثلاثيميا» هو
+
+336
+00:34:00,140 --> 00:34:03,400
+اللي بيعمل الـ هو اللي بيكون سبب الـ «Mutation» أو
+
+337
+00:34:03,400 --> 00:34:07,320
+اللي جعله «ثلاثيميا» مطالبين لإيش إذا شغل ما أنت
+
+338
+00:34:07,320 --> 00:34:11,810
+بترجع تسألي إسألي إن أنت كان مش فاهم أيشأما إذا
+
+339
+00:34:11,810 --> 00:34:17,910
+مطالبين أو مش مطالبين للامتحانات ماشي يعني الإنسان
+
+340
+00:34:17,910 --> 00:34:22,810
+إذا الواحد طبيب وإن شاء الله بس تخلصي تنطلق في هذه
+
+341
+00:34:22,810 --> 00:34:28,690
+الحياة وتشوف ناس وتشوف تعالجي وبدك تسير تسوي كل ما
+
+342
+00:34:28,690 --> 00:34:33,680
+الواحد يكون عنده فهم أحسنبكون أنت دكتور أفضل بيقدر
+
+343
+00:34:33,680 --> 00:34:39,420
+يعالج أفضل بنتبه للأشياء التداخلات مع بعض أما
+
+344
+00:34:39,420 --> 00:34:45,920
+الأساس مطلوب مش مطلوب يعني أنا كمعلوم أنه فيه 70
+
+345
+00:34:45,920 --> 00:34:52,200
+مرتبطة بهذه أه جيد الواحد يمكن يشوف حالة وبعدين
+
+346
+00:34:52,200 --> 00:34:59,290
+ييجي يفحص مثلا mutation في الـDNA مايلقيهاشبس
+
+347
+00:34:59,290 --> 00:35:03,230
+الحالة وراثية، يعني العيلة مصابة ومافيش غيرهم
+
+348
+00:35:03,230 --> 00:35:09,950
+مصابين وبشكل معين، ممكن يكون جزء من الأنواع الأندر
+
+349
+00:35:09,950 --> 00:35:14,970
+اللي مختلفة فأنا ما بطلب منكم ترجعوا على الـ
+
+350
+00:35:14,970 --> 00:35:21,350
+Mandalian Inherited Disease Database بالـ PubMed
+
+351
+00:35:21,350 --> 00:35:26,430
+وأقولك روح دورلي شو هم ولا شو أنواعهم، لأ، لأ،
+
+352
+00:35:26,430 --> 00:35:30,910
+شغلي نادرة جداًبدوا الواحد دايماً يفهم الـBiggest
+
+353
+00:35:30,910 --> 00:35:37,050
+Principles المبادئ الأكبر يعني، ماشي؟ فلا تسألي
+
+354
+00:35:37,050 --> 00:35:40,990
+مطلوب ولا مش مطلوب، إذا في شيء مش واضح، يعني هدول
+
+355
+00:35:40,990 --> 00:35:45,110
+السبعين اللي بيحكوا عنهم، يمكن في الدنيا كلها، كل
+
+356
+00:35:45,110 --> 00:35:49,690
+واحد منهم بتتكلم عن حالة حالتان، أسرة أسرتين، لقوة
+
+357
+00:35:49,690 --> 00:35:52,930
+ما يجي، في كذا، في كذا، في كذا، وراح نضرب أمثلة
+
+358
+00:35:52,930 --> 00:36:02,940
+عليهم، يعني على أشياءفي أسئلة في إشي مش واضح كمان؟
+
+359
+00:36:02,940 --> 00:36:10,780
+طيب بالنسبة
+
+360
+00:36:10,780 --> 00:36:20,920
+لك مبدأ آخر ماشي اللي هي قضية أنه يعني هيك الواحد
+
+361
+00:36:20,920 --> 00:36:28,000
+يفهمها فهم أنه أحيانًاالـ Diseases هي نتيجة
+
+362
+00:36:28,000 --> 00:36:35,120
+Allelic Heterogeneity أو Locus Heterogeneity يعني
+
+363
+00:36:35,120 --> 00:36:38,940
+هنا بالذات،
+
+364
+00:36:38,940 --> 00:36:43,920
+يعني دخلوها بالنسبة للـ Hemoglobin Obesity بالذات،
+
+365
+00:36:43,920 --> 00:36:55,040
+ماشي، قضية اللي هي إنه بالنسبة لمثلًا الـالـ Beta
+
+366
+00:36:55,040 --> 00:36:59,320
+-thalassemia أو بلاش الـ Sickle Cell Anemia إذا
+
+367
+00:36:59,320 --> 00:37:04,280
+بتتذكر يعني فيه الـ Hemoglobin الطبيعي الـ Beta
+
+368
+00:37:04,280 --> 00:37:12,180
+-Chain وفيه الـ Abnormal ففيه واحد ايه مثلا الـ
+
+369
+00:37:12,180 --> 00:37:15,420
+Hemoglobin A هذا هو الـ Normal والـ S Hemoglobin
+
+370
+00:37:15,420 --> 00:37:19,780
+هو الـ Abnormal وبالتالي فيه هنا بيسموه الـ
+
+371
+00:37:19,780 --> 00:37:26,060
+Allelic Heterogeneity بس أحياناًراح نخرج إنه فيه
+
+372
+00:37:26,060 --> 00:37:34,120
+Alpha-1 وAlpha-2 مثلاً في مرات في نفس الـ Protein
+
+373
+00:37:34,120 --> 00:37:37,840
+زي الـ Hemoglobin لأنه Alpha و Beta-Chain في تداخل
+
+374
+00:37:37,840 --> 00:37:43,560
+بين أكثر من Locus بحيث إنه إشي معايشي بيكون أشد
+
+375
+00:37:43,560 --> 00:37:48,500
+أكتر من سبب للمرض وإشي معايشي بيكون أخف وأحسن
+
+376
+00:37:48,500 --> 00:37:56,040
+للمرض فأحيانًا إذا بتدخلأكتر من الـ locus طبعاً كل
+
+377
+00:37:56,040 --> 00:38:01,420
+الـ locus إله قليل إله بدائل بحيث إنه البدائل
+
+378
+00:38:01,420 --> 00:38:06,880
+الموجودة تتدخل في قضية الـ genetic heterogeneity
+
+379
+00:38:06,880 --> 00:38:15,520
+الآن هذا مستوى من التعقيد والاختلافات إنه يكون
+
+380
+00:38:15,520 --> 00:38:21,440
+عنده كل القليل مختلف كل الجين نفسه كـ DNA فيه
+
+381
+00:38:21,440 --> 00:38:27,160
+اختلافاتبس أحيانًا الـ… الـHeterogeneity
+
+382
+00:38:27,160 --> 00:38:31,780
+Phenotypic يعني اللي أتكلمنا على الـPenetrance
+
+383
+00:38:31,780 --> 00:38:38,280
+أتكلمنا على Other Modifications بحيث أنه أحيانًا
+
+384
+00:38:38,280 --> 00:38:45,480
+نفس الجين أو نفس الـLocus بس بيصير عندي Variation
+
+385
+00:38:45,480 --> 00:38:49,880
+في الـPhenotype اللي أنا بشوفهفهي مبدأ يعني أنا
+
+386
+00:38:49,880 --> 00:38:57,520
+بعتبر إنه تكرار لإيش قديم أخدناه بالنسبة لـ
+
+387
+00:38:57,520 --> 00:39:04,480
+Structure of the hemoglobin subunit يكون هذه ناحية
+
+388
+00:39:04,480 --> 00:39:13,300
+مهمة كثيرة الآن هذه الصورة هي three-dimensional
+
+389
+00:39:13,300 --> 00:39:20,600
+structure لـالـ One Hemoglobin Unit فما بدك
+
+390
+00:39:20,600 --> 00:39:25,640
+تتذكروا إنه الـ Hemoglobin الصبغة الحمرة اللي في
+
+391
+00:39:25,640 --> 00:39:29,800
+الدم اللي بتعطي اللون الدم الأحمر وظيفتها حملة
+
+392
+00:39:29,800 --> 00:39:37,980
+الأكسجين عبارة عن أربع Globin Units الأربع Globin
+
+393
+00:39:37,980 --> 00:39:45,900
+Units Two Alphas وTwo Betas الـ Globin يعني إشي
+
+394
+00:39:45,900 --> 00:39:54,830
+كرميعني إشي Globular بشكل زي الطب زي الـ Cut يعني
+
+395
+00:39:54,830 --> 00:39:59,030
+مجموعة طبعاً زي الـ Immunoglobulin أو الـ
+
+396
+00:39:59,030 --> 00:40:04,650
+Hemoglobin حتى يظل بهذا الـ Structure لازم يكون
+
+397
+00:40:04,650 --> 00:40:09,690
+بين قوسين فيه Disulphide Bond لازم يكون فيه إشي
+
+398
+00:40:09,690 --> 00:40:18,430
+بالنص يعني حتىطبّة حبل، طبّة سلك، بدك تمسكها على
+
+399
+00:40:18,430 --> 00:40:22,810
+شكل كروي، بالأخير لازم تحط إشي حتى يمسكها بهذا
+
+400
+00:40:22,810 --> 00:40:31,630
+الشكل، فلو حكينا إحنا بالنسبة لما نقول بالنسبة
+
+401
+00:40:31,630 --> 00:40:37,390
+للـ secondary structure للبروتين، فعندي Alpha
+
+402
+00:40:37,390 --> 00:40:42,010
+Helix اللي هو بلف على شكل، لما يناسب، بتلف على شكل
+
+403
+00:40:42,790 --> 00:40:48,410
+بتصير حبل غليظ كثير وملتوى على نفسه أو Beta-plated
+
+404
+00:40:48,410 --> 00:40:53,150
+sheets بيكون خط رايح أو خط جاي بحيث بيعطينا زي شكل
+
+405
+00:40:53,150 --> 00:40:59,470
+الورقة أو سطح إشي هيك مستوي فالـ Hemoglobin اللي
+
+406
+00:40:59,470 --> 00:41:06,430
+بدنا نتذكره في الـHelicytes بيسموها Alpha وBeta A
+
+407
+00:41:06,430 --> 00:41:14,160
+وB وC وD وE وH وJ وكدهبدي يكون بهذا الشكل ماشي
+
+408
+00:41:14,160 --> 00:41:19,100
+وترتيب الـ Folding بتبعه بهذا الشكل هاي بالـ X-Ray
+
+409
+00:41:19,100 --> 00:41:24,380
+Crystallography بتقدر الواحد يشوفها وهي قضية
+
+410
+00:41:24,380 --> 00:41:30,340
+مرتبطة بالـ Primary Structure إنه بتخليه يفضل إنه
+
+411
+00:41:30,340 --> 00:41:36,700
+يكون يستقر على هذا الشكل بنلاحظ فيه Dysulfide Bond
+
+412
+00:41:36,700 --> 00:41:44,030
+وباعتبره هنا إنهالـ Phenylalanine at position 42
+
+413
+00:41:44,030 --> 00:41:50,830
+وتقريبًا 150 Amino Acid ماشي، يعني 147 يعني بالضبط
+
+414
+00:41:50,830 --> 00:41:57,270
+بالضبط حاطين رقم، ماشي 150 Amino Acid بلف بهذا
+
+415
+00:41:57,270 --> 00:42:03,670
+الشكل، ماشي في الـ Phenylalanine at position 42
+
+416
+00:42:03,670 --> 00:42:12,050
+مرتبط مع الهستدينبالـ Position 92 فيه Dysulfide
+
+417
+00:42:12,050 --> 00:42:17,950
+Bond أو فيه رابطة هنا زائد الـ Heme Structure الـ
+
+418
+00:42:17,950 --> 00:42:27,930
+Heme هذا عبارة عن اللي هو ببدأ من يعني اللي يعني
+
+419
+00:42:27,930 --> 00:42:32,570
+لما نتحطم هو بروفايرول الـ Ring إشي بالـ
+
+420
+00:42:32,570 --> 00:42:36,590
+Biochemistry اللي راح تخلوه عبارة عن Ring كبيرةلما
+
+421
+00:42:36,590 --> 00:42:40,830
+تتكسر تعطينا الـ bilirubin والـ biliverdin بس
+
+422
+00:42:40,830 --> 00:42:45,170
+missed الـ hemoglobin الـ hem molecule أو الـ hem
+
+423
+00:42:45,170 --> 00:42:51,530
+ring أنه بالأخير بنصها راح تيجي الـ iron atom و
+
+424
+00:42:51,530 --> 00:42:57,810
+لازم تكون الـ iron at plus two يعني فرس مش فرق مش
+
+425
+00:42:57,810 --> 00:43:01,830
+plus three إذا صارت plus three راح يصير met
+
+426
+00:43:01,830 --> 00:43:07,330
+hemoglobin وبشتغلش كويس، مايفيدشوالـ Iron هو اللي
+
+427
+00:43:07,330 --> 00:43:15,870
+بيحمل الـ Oxygen فهي هي الـ Structure تبع One Unit
+
+428
+00:43:15,870 --> 00:43:22,310
+of Hemoglobin فبنسميها الـ Hemoglobin Subunit فيه
+
+429
+00:43:22,310 --> 00:43:27,170
+ثنتين Alpha وثنتين Beta الأربعة بيشتركوا مع بعض
+
+430
+00:43:27,170 --> 00:43:31,830
+فيهم أربعة Hem أربعة Iron وبيمسكوا الـ Oxygen
+
+431
+00:43:31,830 --> 00:43:36,300
+وبيحملوا الـ Oxygen وينقلوا خدسةفهذه الـ Structure
+
+432
+00:43:36,300 --> 00:43:46,760
+تبع الـ الـ الـ Hemoglobin و Sub-unit وبيركزوا على
+
+433
+00:43:46,760 --> 00:43:52,040
+إنه يعني حتى يظل الـ Structure بهذا الشكل لازم
+
+434
+00:43:52,040 --> 00:43:54,860
+يمسك دائر الـ Sulphide Bond لازم يكون فيه Bond
+
+435
+00:43:54,860 --> 00:44:03,220
+قوية وفيه pocket زي جيبة لأي محل حتى يقدر الـ Mem
+
+436
+00:44:03,690 --> 00:44:08,810
+الـ molecule يدخل ويكون الـ iron عليها حتى يمسك
+
+437
+00:44:08,810 --> 00:44:17,090
+الـ oxygen فيها أسئلة؟ في حد عنده سؤال؟
+
+438
+00:44:17,090 --> 00:44:24,730
+طيب فالـ hemoglobin normally it will be like this
+
+439
+00:44:24,730 --> 00:44:35,530
+طيب، لما نيجي ندرس كيف الجينات بالأولتبعته بتشتغل
+
+440
+00:44:35,530 --> 00:44:39,070
+الحكاية
+
+441
+00:44:39,070 --> 00:44:43,710
+اللي حكيناها في عندي أنا two الـ hemoglobin
+
+442
+00:44:43,710 --> 00:44:49,710
+molecule فيه له two subunits فيه Alpha وفيه Beta
+
+443
+00:44:49,710 --> 00:44:56,530
+الـ Alpha في أظن الـ Chromosome 16 إذا قريتها
+
+444
+00:44:56,530 --> 00:45:07,770
+بعدين بنلاحظ أنهأظن أن هذه إيتا الـ Alpha-like
+
+445
+00:45:07,770 --> 00:45:12,930
+genes في عندي Alpha-1 و Alpha-2 في عندي الـ Eta
+
+446
+00:45:12,930 --> 00:45:23,890
+هذه الـ أو Zeta أقل Zeta حرف يوناني أو من الأحرف
+
+447
+00:45:23,890 --> 00:45:30,610
+القديمة و أظن Zeta الآن
+
+448
+00:45:58,330 --> 00:45:59,730
+بالنسبة
+
+449
+00:45:59,730 --> 00:46:01,130
+لـ’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’�
+
+450
+00:46:02,050 --> 00:46:08,990
+والـ Alpha هي جزء من الـ Hemoglobin الـ Beta هي
+
+451
+00:46:08,990 --> 00:46:16,910
+عندي خمسة وواحدة Beta الرئيسية وهنا Epsilon وGamma
+
+452
+00:46:16,910 --> 00:46:25,970
+Delta وA Delta وأسف Gamma G Gamma وA Gamma وI
+
+453
+00:46:25,970 --> 00:46:30,690
+Delta يعني
+
+454
+00:46:31,760 --> 00:46:40,820
+النقطة هذه ماشية بدّي الواحد يعني يربطها بالجدول
+
+455
+00:46:40,820 --> 00:46:48,440
+اللي تحت يعني الـHemoglobin في حياة الإنسان لما
+
+456
+00:46:48,440 --> 00:46:55,100
+نتكلم على مراحله الـEmpirionic Period الـEarly
+
+457
+00:46:55,100 --> 00:47:01,700
+Empirionic Period بعدين الـFeta Life بعدين الـالـ
+
+458
+00:47:01,700 --> 00:47:08,760
+Adult Life أو الـ Later Life الـ Life الحياة بعدين
+
+459
+00:47:08,760 --> 00:47:15,680
+لازم يكون الـ Hemoglobin اللي بتكون عندي مختلف في
+
+460
+00:47:15,680 --> 00:47:25,300
+كل مرحلة السبب واضح يعني السبب أنه أنا لما أكون في
+
+461
+00:47:25,300 --> 00:47:32,430
+بطن أمي وأنا جنينالـ Lungs ما عندي Lungs ما عندي
+
+462
+00:47:32,430 --> 00:47:38,230
+إشي يأخذ الـ Oxygen من الهوى أو من المي كسمكة ولا
+
+463
+00:47:38,230 --> 00:47:43,450
+إشي الـ Hemoglobin اللي أنا بدي أخده الـ Acid الـ
+
+464
+00:47:43,450 --> 00:47:46,710
+Oxygen اللي بدي أخده في حالة الـ embryonic period
+
+465
+00:47:46,710 --> 00:47:52,510
+أو الـ fetal period بيجي من وين؟ بيجي من الأم بيجي
+
+466
+00:47:52,510 --> 00:47:57,870
+من الـ machine الـ placenta اللي بيصير فيها إنه
+
+467
+00:47:57,870 --> 00:48:05,760
+بقتربدم الجنين مع دم الأم فإذا في المرحلة الجنينية
+
+468
+00:48:05,760 --> 00:48:14,040
+الـ Affinity اللي هي قوة استقطاب وتماسط أو مسك الـ
+
+469
+00:48:14,040 --> 00:48:21,260
+Hemoglobin للـ Oxygen متماثلة مع تبع الأم النتيجة
+
+470
+00:48:21,260 --> 00:48:26,160
+راح تكون إنه أنا مارح أقدر أخذ منها Oxygen ناشي،
+
+471
+00:48:26,160 --> 00:48:32,570
+فبالتاليما بيكون فيه Oxygen للجنين فلازم حتى ينجح
+
+472
+00:48:32,570 --> 00:48:39,270
+الـ Oxygen تبع الجنين أنه يأخذ الـ Oxygen عشان
+
+473
+00:48:39,270 --> 00:48:42,390
+ينجح الـ Hemoglobin تبع الجنين أنه يمسك الـ Oxygen
+
+474
+00:48:42,390 --> 00:48:46,430
+من الـ Hemoglobin تبع الأم لازم تكون الـ Affinity
+
+475
+00:48:46,430 --> 00:48:52,670
+تبعته للـ Oxygen أقوى من تبع الأم فبالتالي احنا في
+
+476
+00:48:52,670 --> 00:48:58,170
+عنا أكثر من نوع من Hemoglobinوالأنواع اللي بتطلع
+
+477
+00:48:58,170 --> 00:49:03,690
+في كل مرحلة لازم تكون نوعية مختلفة وبتكون بهذا
+
+478
+00:49:03,690 --> 00:49:10,630
+الشكل في نقطة يعني أنا بتأكد أكيد مرت عليكم
+
+479
+00:49:10,630 --> 00:49:16,450
+بالنسبة للـElectrophoresis أو اللي هي تكون الدم إن
+
+480
+00:49:16,450 --> 00:49:20,030
+الخلايا اللي بتكون الدم الـMetabiotic Stem Cell
+
+481
+00:49:20,030 --> 00:49:24,640
+والأشياء هذهفي المرحلة الأولى تبدأ في كيس المحة
+
+482
+00:49:24,640 --> 00:49:29,440
+اللي هو الكيس اللي فيه الصفار اللي في البيض بالله
+
+483
+00:49:29,440 --> 00:49:32,980
+فيه اللي هو ما يسمونه الـ Yolksa في مرحلة معينة من
+
+484
+00:49:32,980 --> 00:49:37,700
+حياة الجنين الـ Embryonic، Airy-Embryonic بتكون
+
+485
+00:49:37,700 --> 00:49:44,300
+الدم بتكون في الـ Yolksa بعدين later these cells
+
+486
+00:49:44,300 --> 00:49:48,960
+migrate into the liver وSpleen وكونهم المصدر
+
+487
+00:49:48,960 --> 00:49:54,130
+الأكبروراح نشوف إذا دخل في الأمراض إنه يظل زي في
+
+488
+00:49:54,130 --> 00:49:57,430
+التلاثيمية إنه يظل إلتاج الدم من الـ Liver و
+
+489
+00:49:57,430 --> 00:50:04,050
+الـSpleen بس بالأخير عند الولادة وعادة في بقية
+
+490
+00:50:04,050 --> 00:50:11,250
+حياة الإنسان الدم بتتكون بالبومارو فهذه المراحل
+
+491
+00:50:11,250 --> 00:50:19,940
+اللي من وين تطلع الدم من الإنسانإذا شُفنا أنواع
+
+492
+00:50:19,940 --> 00:50:26,160
+الدم اللي بيكون موجود، ماشي في ملاحظة قريتها لأنه
+
+493
+00:50:26,160 --> 00:50:31,960
+كنت أقرن بارح إنه بالنسبة للـ Alpha والـ Beta
+
+494
+00:50:31,960 --> 00:50:37,820
+-Genes عادة من الـEmpirionic أو Early Empirionic
+
+495
+00:50:37,820 --> 00:50:45,020
+للـFetal للأدلالـ Transcription بيكون بالأول
+
+496
+00:50:45,020 --> 00:50:48,860
+بيستخدم النوع الأول بعدين بيصير يستخدم النوع
+
+497
+00:50:48,860 --> 00:50:53,140
+الثاني أو الثالث اللي دولة مع بعض بس بالنسبة للـ
+
+498
+00:50:53,140 --> 00:50:58,460
+Beta Chain بيبدأ نوع معين بعدين بيصير لنوع ثاني و
+
+499
+00:50:58,460 --> 00:51:05,680
+النوع الثاني بعدين بتحول لنوع ثالث، ماشي؟ يعني
+
+500
+00:51:05,680 --> 00:51:13,980
+إحنا المهماتيعني اللي بدك تذكره أنه أحنا بشكل
+
+501
+00:51:13,980 --> 00:51:21,200
+طبيعي كأدل 95% أو أكثر Hemoglobin A اللي هو Alpha
+
+502
+00:51:21,200 --> 00:51:29,800
+2 Beta 2 أحنا هذا تبعنا كأدل فيه 3، 4، 5% اللي هو
+
+503
+00:51:29,800 --> 00:51:38,890
+A2 اللي هو Alpha 2 Delta 2 بهذا الشكل ماشي؟في
+
+504
+00:51:38,890 --> 00:51:43,750
+الحالة اللي حكيناها اللي هي الـ Persistence of
+
+505
+00:51:43,750 --> 00:51:49,330
+Hemoglobin F الـ Hemoglobin F هي Alpha 2 Gamma 2
+
+506
+00:51:49,330 --> 00:51:56,330
+نوع ثاني من الـ Beta Chain ماشي هدولة الثلاثة اللي
+
+507
+00:51:56,330 --> 00:52:01,810
+بدي أقوم Goer 1 و Goer 2 و Portland يعني Early
+
+508
+00:52:01,810 --> 00:52:06,130
+Empyrionic Period اللي قصد في الموضوع إنه كل ما
+
+509
+00:52:06,130 --> 00:52:11,830
+نمشي من هون لهونالـ Affinity للـ Oxygen بتقل يعني
+
+510
+00:52:11,830 --> 00:52:16,370
+هذا very strongly associated with يعني بمُص الـ
+
+511
+00:52:16,370 --> 00:52:20,490
+Oxygen قوي كتير حتى يقدر يُخض من الـ Ohm و بعدين
+
+512
+00:52:20,490 --> 00:52:27,110
+هنا أحسن شوية أو أخف شوية بس لسه أحسن من الـ A1 أو
+
+513
+00:52:27,110 --> 00:52:33,570
+الـ A و الـ A2 هنا مافيش A1، حاطين A و A2 نلتزم زي
+
+514
+00:52:33,570 --> 00:52:41,030
+ما هم حاكين، فالخلاصة تبع الموضوع هذا أنه أنا
+
+515
+00:52:41,030 --> 00:52:45,010
+بالنسبة للـ Hemoglobin Molecule في عندي Alpha
+
+516
+00:52:45,010 --> 00:52:51,130
+Chain و Beta Chain فنتين فنتين كل واحد فيها هيم
+
+517
+00:52:51,130 --> 00:52:57,050
+هذا الـFull Hemoglobin اللي عندي يعني في اللي
+
+518
+00:52:57,050 --> 00:53:07,230
+بيشترك ضمن يعني إذا بنشوف الـ… الجدول الأخيرماشي،
+
+519
+00:53:07,230 --> 00:53:13,490
+في الـ Empyrionic Period بالنسبة لـ بالأول ببدأ
+
+520
+00:53:13,490 --> 00:53:18,710
+يعني حتى بفترة مبكرة الـ Alpha Chain بيكون هو الـ
+
+521
+00:53:18,710 --> 00:53:23,230
+dominant وطبعاً دي Alpha 1 و Alpha 2 ويكون موجود
+
+522
+00:53:23,230 --> 00:53:26,890
+يمكن نسبة شويه مختلفة ولا كده بس اللي هي الـ Alpha
+
+523
+00:53:26,890 --> 00:53:31,330
+Chain وإنه في الـ Empyrionic Period في إيش اسمه
+
+524
+00:53:31,330 --> 00:53:35,920
+بالنسبة للـ Beta Chain في اسمها الـ Gamma Chainالـ
+
+525
+00:53:35,920 --> 00:53:39,400
+Gamma Chain هي بديل عن الـ Beta Chain ولمّا
+
+526
+00:53:39,400 --> 00:53:43,980
+الإنسان يولد يصير switch في حياته إنه بيبطل يطلع
+
+527
+00:53:43,980 --> 00:53:48,120
+الـ F-Hemoglobin يصير يطلع الـ Alpha الـ A
+
+528
+00:53:48,120 --> 00:53:53,380
+-Hemoglobin والـ Gamma
+
+529
+00:53:53,380 --> 00:54:02,780
+بيبطل يطلع ماشي لحد معين بنلاقي الـ Gamma صار ينزل
+
+530
+00:54:02,780 --> 00:54:08,040
+وذا ظل موجود يبقىراح يا إما يعمل Pick مشكلة أو
+
+531
+00:54:08,040 --> 00:54:12,100
+يحسّي المشكلة تانية، راح نهتز يعني وفيه عندنا
+
+532
+00:54:12,100 --> 00:54:18,300
+بالنسبة بسيطة جداً، 5 بـ2، 3، 4% بدل الـBeta Chain
+
+533
+00:54:18,300 --> 00:54:25,800
+فيه عندي الـDelta Chain اللي راح تعطيني الـA2 فأنا
+
+534
+00:54:25,800 --> 00:54:33,470
+بعتبر هذا الـSlide وهذا الجدول من أهم الجدولوهذا
+
+535
+00:54:33,470 --> 00:54:37,410
+بدي إياكم تفهموا الـ Go where one و two و three أو
+
+536
+00:54:37,410 --> 00:54:41,690
+Portland و الأشياء هذه بديش إياها، هي مش مهمة بس
+
+537
+00:54:41,690 --> 00:54:49,170
+علاقات الـ F و الـ A2 و الـ A و الأنواع المختلفة و
+
+538
+00:54:49,170 --> 00:54:54,170
+كيف ثم بيجوا و كيف التطورها في حياة الإنسان أنا
+
+539
+00:54:54,170 --> 00:54:58,890
+باعتبر هذه أهم الجوانب و لازم واحد يكون مذكرها و
+
+540
+00:54:58,890 --> 00:54:59,610
+فاهمها
+
+541
+00:55:03,130 --> 00:55:10,530
+هذه هي الـ Genetic Basis وهنا الناس، يعني We are
+
+542
+00:55:10,530 --> 00:55:16,230
+describing the normal development of Hemoglobin
+
+543
+00:55:16,230 --> 00:55:23,830
+production بيكون على مراحل مختلفة، لأنواع مختلفة،
+
+544
+00:55:23,830 --> 00:55:31,740
+بالجينات مختلفة واللي بنبه عليه أنه يعني تركيبكأنه
+
+545
+00:55:31,740 --> 00:55:36,540
+فيه حاجة Controller بمرحلة معينة بيخلّي هذا النوع
+
+546
+00:55:36,540 --> 00:55:40,120
+يطلع بعد شويه اللي بعده وبعد شويه اللي بعده
+
+547
+00:55:40,120 --> 00:55:45,320
+بالنسبة للـ Beta-Chain النوع الأول بشكل معين بعدين
+
+548
+00:55:45,320 --> 00:55:49,040
+النوع التاني وبعدين النوع التالف، بهذا الشكل يعني
+
+549
+00:55:49,040 --> 00:55:54,440
+أن الأصل أنه في كل مرحلة بتلاقي نوعية معينة من
+
+550
+00:55:54,440 --> 00:55:58,610
+الـHemoglobin لازم تطلعوبعدين بس يخلص وبنتقل على
+
+551
+00:55:58,610 --> 00:56:03,130
+النوع اللي بعدها حسب الاحتياج وحسب الوضع وحسب حياة
+
+552
+00:56:03,130 --> 00:56:08,990
+الإنسان سبحان الله تفاصيل
+
+553
+00:56:08,990 --> 00:56:16,070
+الـ Beta المعقدة أكتر وبالذات أنواع الـ Genetic
+
+554
+00:56:16,070 --> 00:56:24,050
+Mutation حكينا عنها بالنسبة
+
+555
+00:56:24,050 --> 00:56:31,880
+لـيعني للـ Hemoglobin بذكر مرة ثالثة لما نقول
+
+556
+00:56:31,880 --> 00:56:39,780
+Hemoglobinopathy يا إما نوعية نعتبرها اللي هي
+
+557
+00:56:39,780 --> 00:56:46,500
+Quantitative وفي Qualitative فالـ Qualitative ماشي
+
+558
+00:56:46,500 --> 00:56:54,800
+اللي هي إنه شكل الـ Hemoglobin اختلفما هم نتكلم
+
+559
+00:56:54,800 --> 00:57:00,240
+على بروتين طبيعي وكميته اختلفت، لأ هنا انه صار فيه
+
+560
+00:57:00,240 --> 00:57:08,860
+إشي عملناه مشكلة أهم نوع الـ Hemoglobin-S اللي هو
+
+561
+00:57:08,860 --> 00:57:12,820
+بعطينا Sickle Cell Disease Sickle Cell Disease
+
+562
+00:57:12,820 --> 00:57:18,040
+الـHemoglobin اللي فيه بيسموه Hemoglobin-S وهي
+
+563
+00:57:18,040 --> 00:57:25,560
+Autosomal Recesses اللي بيصيرإنه في الـ يعني لازم
+
+564
+00:57:25,560 --> 00:57:31,440
+واحد يكون يقدر يقرا هذه الـ Notation اللي هي إن
+
+565
+00:57:31,440 --> 00:57:40,060
+الـ Beta Chain الـ Position رقم 6 في الـ Glutamine
+
+566
+00:57:40,060 --> 00:57:44,300
+أظن أن الـ Amino Acid Glutamine بتتحول لـ Valine
+
+567
+00:57:44,300 --> 00:57:49,420
+فهي Amino Acid Substitution وهي لما نكتبوا لكم
+
+568
+00:57:49,420 --> 00:57:54,010
+الأرقام هذهالـ Glutamine position 26 صار Lycine
+
+569
+00:57:54,010 --> 00:58:00,970
+أسبارجين هذا position 99 صار ASM يجب أن يقرأ أحد
+
+570
+00:58:00,970 --> 00:58:06,470
+ما هو الـ Amino Acid نتيجة المشكلة هذه فهذه الـ
+
+571
+00:58:06,470 --> 00:58:11,190
+notation لازم الواحد يعرفها
+
+572
+00:58:11,190 --> 00:58:20,640
+الـ Sickle Cell Disease عبارة عنيعني كيف تبدأ
+
+573
+00:58:20,640 --> 00:58:26,000
+الأمر من الـGenetics
+
+574
+00:58:26,000 --> 00:58:31,280
+لـDisease Phenotype لشو اللي بنشوفه على المريض
+
+575
+00:58:31,280 --> 00:58:34,620
+الـGenetic
+
+576
+00:58:34,620 --> 00:58:41,560
+Basis إنه الـNormal Kodon GAG فبتتحول لسكل سلك
+
+577
+00:58:41,560 --> 00:58:51,030
+كودون تبع GTG بدل الـASRTفالـ Glutamine الـ «جي
+
+578
+00:58:51,030 --> 00:58:56,030
+أليو» اتحول لـ «فالين» هذا الـ «فالين» إذا بتتذكره
+
+579
+00:58:56,030 --> 00:59:03,050
+أظنه Hydrophobic تحب يشيل ميه وهذا Hydrophilic
+
+580
+00:59:03,050 --> 00:59:09,510
+طبعاً يعني سبحان الله ليش الـ Folding تيسير بالشكل
+
+581
+00:59:09,510 --> 00:59:14,410
+هذا؟ إله دخل إنه لما يسير الـ Folding بشكل طبيعي
+
+582
+00:59:14,410 --> 00:59:20,280
+اللي على السطح لازم يكونHydrophilic يعني بيحب
+
+583
+00:59:20,280 --> 00:59:27,140
+الميه واللي جوا بيكون Hydrophobic لأنه بيكون لازم
+
+584
+00:59:27,140 --> 00:59:32,020
+يكره الميه حتى يظلوا جوا ويكونوا جوا عشان مايتعرضش
+
+585
+00:59:32,020 --> 00:59:39,580
+للميه فنتيجة الاختلال هذا من Hydrophilic على
+
+586
+00:59:39,580 --> 00:59:45,000
+Hydrophobic على position معين تصير إنه
+
+587
+00:59:45,000 --> 00:59:50,310
+الـHemoglobin الـSفي حالة لما يكون Oxygenated
+
+588
+00:59:50,310 --> 00:59:54,830
+Hemoglobin في الـRed Blood Cell بتكون
+
+589
+00:59:54,830 --> 01:00:00,470
+الـHemoglobin موليكيولز يتسفرد بالشكل الطبيعي في
+
+590
+01:00:00,470 --> 01:00:06,330
+حالة الـDeoxyhemoglobin ماشي، لما يبطل ويقل نسبة
+
+591
+01:00:06,330 --> 01:00:14,310
+الأكسجين ويتحول إلى Deoxy الـHydrophobic يعني
+
+592
+01:00:14,310 --> 01:00:20,740
+الـPatch كانت تخيل عند الكرافةالأصل الكورات تضربوا
+
+593
+01:00:20,740 --> 01:00:26,680
+بعض وما يكونش فيها أي شيء لأ الكورة اتغيرت بحيث
+
+594
+01:00:26,680 --> 01:00:30,900
+أنه على قطعة منها أو على جانب معين صار إشي بلزق
+
+595
+01:00:30,900 --> 01:00:38,640
+صار إشي sticky فلما يصير ديوكسيهيمoglobin المنطقة
+
+596
+01:00:38,640 --> 01:00:43,060
+اللي بتلزق هذه بتبين أكتر وبتكون أكتر وبنتج عنها
+
+597
+01:00:43,060 --> 01:00:50,220
+أنها بتتجمع فييعني كريستال يعني على شكل بلورة هي
+
+598
+01:00:50,220 --> 01:01:05,280
+إشي كبير وإشي يعني صلب فالأصل الخلية الـ Red blood
+
+599
+01:01:05,280 --> 01:01:09,660
+cells اللي هي Biconcave بهذا الشكل easily
+
+600
+01:01:09,660 --> 01:01:15,270
+deformable يعنيتقدر تتلوى، تقدر تتغير في حالها
+
+601
+01:01:15,270 --> 01:01:21,110
+بحيث أنه تقدر تفوت في أماكن ضيقة فلمّا يصير عندي
+
+602
+01:01:21,110 --> 01:01:27,330
+الشكل السكن اللي هو المنجل بهذا الشكل نتيجة تكوّن
+
+603
+01:01:27,330 --> 01:01:32,110
+crystals من الـHemoglobin-S يصير عندي non
+
+604
+01:01:32,110 --> 01:01:37,600
+-deformability بتبطل، تقدر تتلوىاللي بيصير عندي
+
+605
+01:01:37,600 --> 01:01:42,380
+بيصير vasoclosion فبيصير عندي hemolysis جزء منه
+
+606
+01:01:42,380 --> 01:01:47,220
+وبيصير عندي تسكير بالـ capillaries بالشعيرات
+
+607
+01:01:47,220 --> 01:01:58,800
+الدموية وهذا سبب أساسي في المرض ناشي بالنسبة
+
+608
+01:01:58,800 --> 01:02:05,430
+للـ hemoglobin hemoglobin repressive اللي همالـ
+
+609
+01:02:05,430 --> 01:02:13,070
+نتيجة الـ hemoglobinopathies نتيجة الـ qualitative
+
+610
+01:02:13,070 --> 01:02:20,990
+qualitative في عندي أكثر من نوع بس ده يعني أنا إذا
+
+611
+01:02:20,990 --> 01:02:26,710
+بتذكر الـ hemoglobin S وتفاصيله بيكفي في الـ
+
+612
+01:02:26,710 --> 01:02:33,350
+hemoglobin Hammersmith بيسوي Hemolysis وبكون له
+
+613
+01:02:33,350 --> 01:02:38,500
+Oxygen Affinityبكون عندي «تغيير» مختلف «هيموجلوبين
+
+614
+01:02:38,500 --> 01:02:44,420
+هايتبارد» أو «هيموجلوبين M» بيسمينه بيكون عندي
+
+615
+01:02:44,420 --> 01:02:50,080
+«سيانوسس» ماشي، أحد أسباب أن المريض عنده ذرقاق
+
+616
+01:02:50,080 --> 01:02:58,100
+«كمسي» اللي هو polycythemia «هيموجلوبين E» بيعطينا
+
+617
+01:02:58,100 --> 01:03:04,430
+mild thalassemia فالـ «هيموجلوبين S» هي mutationفي
+
+618
+01:03:04,430 --> 01:03:10,050
+الـ Beta Chain وهيك بيعطينا، والأصل إنها Autosomal
+
+619
+01:03:10,050 --> 01:03:18,690
+Recesses لمن آجي أنا، بالنسبة بالذات لـHemoglobin
+
+620
+01:03:18,690 --> 01:03:24,710
+S ليش مهمة؟ وليش هيك؟ يعني كثير بدرسوها، وطبعاً في
+
+621
+01:03:24,710 --> 01:03:30,650
+كثير نسب مرضى Sickle Cell، والله يعينهمبعمل أمراض
+
+622
+01:03:30,650 --> 01:03:35,210
+كثيرة يعني بيسموهم حتى بيجيك المريض بـ Crisis
+
+623
+01:03:35,210 --> 01:03:42,470
+بيجيك بأزمة يعني وضع مأزوم جداً جداً في منها الـ
+
+624
+01:03:42,470 --> 01:03:48,230
+Painful Crisis يعني نتيجة تسكير القنوات الدم أو
+
+625
+01:03:48,230 --> 01:03:52,950
+الأوعي الدموية بيصير عندنا ألم شديد ونقص ثروية في
+
+626
+01:03:52,950 --> 01:03:57,210
+الأشي نقص ثروية في الدمار في القلب، في الرئتين، في
+
+627
+01:03:57,210 --> 01:04:02,600
+الـفي الرجلين، في الظهر، في كده ويبقى عندنا حتى
+
+628
+01:04:02,600 --> 01:04:08,260
+Infarction وكده وكده فبيسموه Painful Crisis فيه
+
+629
+01:04:08,260 --> 01:04:11,920
+Hemolytic Crisis بالذات يمكن مع بعض الـ Infection
+
+630
+01:04:11,920 --> 01:04:18,140
+أو بيصير إشي بيصير تكسر بالدم كتير فيه A Plastic
+
+631
+01:04:18,140 --> 01:04:24,080
+Crisis إنه من كتر ما البومر أشتغل بيصير عندي إيش
+
+632
+01:04:24,080 --> 01:04:28,900
+اسمه؟failure of the bomber وإن بطل الـ bomber يقدر
+
+633
+01:04:28,900 --> 01:04:33,520
+يشتغل فمنتج عنه aplastic crisis فهدوله كله منه
+
+634
+01:04:33,520 --> 01:04:38,620
+هدوله بيجيكوا حالات راح تيجي في الطوارئ تكون إنت
+
+635
+01:04:38,620 --> 01:04:43,200
+قاعد في الطوارئ يجيك مريض أو إنسان كان طبيعي وصار
+
+636
+01:04:43,200 --> 01:04:47,540
+نتيجة مشكلة مثلا صار عنده infection دخل ب painful
+
+637
+01:04:47,540 --> 01:04:55,690
+crisis أو aplastic أو hemolytic أوطبعًا يعني لو
+
+638
+01:04:55,690 --> 01:05:00,190
+شُفتوا المرضى الـsickle cell دايماً ممكن يوصلوا أن
+
+639
+01:05:00,190 --> 01:05:08,610
+يصيروا يعني عندهم إدمان
+
+640
+01:05:08,610 --> 01:05:13,630
+على المخدرات لأنه دايماً عندهم ألم شديد وبدوا دوة
+
+641
+01:05:13,630 --> 01:05:20,030
+قوية مورفين وغيره وغيره عشان يعالجها أو أنه مثلًا
+
+642
+01:05:20,030 --> 01:05:31,530
+بدخل أنهالـ Cyclers بيصيروا مثلًا بالأول نتيجة
+
+643
+01:05:31,530 --> 01:05:37,930
+بيهم الأطفال بيكون عندهم Spleen وMegaly الـ Spleen
+
+644
+01:05:37,930 --> 01:05:42,770
+بيكون كبير كتير نتيجة إنه الـ Bomber بيحاول يطلع
+
+645
+01:05:42,770 --> 01:05:49,270
+دم ومش ملحق وبيصير مشاكل فيها إنه الـ Bomber بيكون
+
+646
+01:05:50,540 --> 01:05:54,740
+بالأول Hyperactive وبالتالي بيصير عندهم
+
+647
+01:05:54,740 --> 01:05:59,460
+الـSplenomegaly بس لأنه بيصير Auto-infarction
+
+648
+01:05:59,460 --> 01:06:04,080
+بيصير الـOcclusive crises بالـCapillaries in the
+
+649
+01:06:04,080 --> 01:06:07,940
+spleen فبيصير عندهم By the age of eight to ten
+
+650
+01:06:07,940 --> 01:06:14,280
+بيسموه Auto-splenectomy يعني الـSpleen بتحطم من
+
+651
+01:06:14,280 --> 01:06:20,640
+جوافعادة اللي عندهم Sickle Cell على عمر العشر سنين
+
+652
+01:06:20,640 --> 01:06:24,980
+مايحسسش الـSpleen ولو بيجينا نتحسسهم مايلاقيش
+
+653
+01:06:24,980 --> 01:06:29,880
+عندهم أو عندهم Atrophic Spleen أو Spleen ضامر
+
+654
+01:06:29,880 --> 01:06:38,240
+مافيش عندهم Spleen في نقطتين ليش؟ في يعني وراح
+
+655
+01:06:38,240 --> 01:06:43,980
+نشوفها بعد شوية الـHemoglobin S طبعاً إله أنواع
+
+656
+01:06:43,980 --> 01:06:51,120
+يعنيممكن إنسان يكون Carrier يعني نص اللي عنده
+
+657
+01:06:51,120 --> 01:06:56,280
+Hemoglobin S ونصها اللي عنده Disease اللي بنسميه
+
+658
+01:06:56,280 --> 01:07:00,780
+يعني مريض بالـ Sickness and Anemia اللي بيكون عنده
+
+659
+01:07:00,780 --> 01:07:09,000
+SS Hemoglobin يعني الـTintin اللي عنده SAوعنده SA
+
+660
+01:07:09,000 --> 01:07:15,220
+أو SA2 أو يعني نوعيتين مختلفتين هذا الـ Carrier
+
+661
+01:07:15,220 --> 01:07:21,220
+بيكون أحسن الـ Carrier بالذات للـ Hemoglobin S الـ
+
+662
+01:07:21,220 --> 01:07:27,780
+Carrier State في كلام كتير على إن هؤلاء الناس
+
+663
+01:07:27,780 --> 01:07:32,960
+النتيجة إن الـ Hemoglobin S بيكونوا resistant to
+
+664
+01:07:32,960 --> 01:07:39,130
+malariaعشان هيك يعني كملاحظة إذا بتسوي هيك الـ
+
+665
+01:07:39,130 --> 01:07:44,030
+Mapping في العالم للمرضى اللي عندهم Sickle Cell S
+
+666
+01:07:44,030 --> 01:07:49,290
+-Hemoglobin والملاريا بتلاقيهم أشياء مع بعض يعني
+
+667
+01:07:49,290 --> 01:07:52,670
+منطقة حوض البحر اللي قدرهم توصل في أفريقيا في
+
+668
+01:07:52,670 --> 01:07:57,510
+أماكن معينة وإما بتشوف فيه ملاريا كتير بتلاقي نسبة
+
+669
+01:07:57,510 --> 01:08:05,450
+الـHemoglobin S أكترففي ناس يعني في نظرية لكل واحد
+
+670
+01:08:05,450 --> 01:08:09,990
+دقيق إن الـ S-Hemoglobin بيعطي نوع من الـ
+
+671
+01:08:09,990 --> 01:08:16,090
+Resistance للملاريا وفي يعني كلام على إنه لأ لأن
+
+672
+01:08:16,090 --> 01:08:20,830
+الـ Hemoglobin S المشكلة تبعته لما يكون D
+
+673
+01:08:20,830 --> 01:08:26,030
+-Oxyhemoglobin S أما لما يكون Oxyhemoglobin S مش
+
+674
+01:08:26,030 --> 01:08:33,050
+مشكلة كتير يعني إنه علىالمناطق يعني المرتفعات
+
+675
+01:08:33,050 --> 01:08:36,950
+بيكون الـOxygen أقل واحتمالية الـDeoxygenation
+
+676
+01:08:36,950 --> 01:08:42,870
+أكبر وبالتالي ما يكونش موجود بشكل، يعني فيه
+
+677
+01:08:42,870 --> 01:08:47,830
+selection الإختيار الطبيعي اللي هو الـNatural
+
+678
+01:08:47,830 --> 01:08:52,990
+Selection اللي بعتبره يعني بديل عن يعني أو جزء من
+
+679
+01:08:52,990 --> 01:08:59,500
+التفسير ليش الأمور تمشي بهذا الشكلففي عندي أكتر من
+
+680
+01:08:59,500 --> 01:09:07,600
+نوع وعندي هدولة مشاكل بسميهم نتيجة الـHemoglobin
+
+681
+01:09:07,600 --> 01:09:14,220
+ممكن الـHemoglobin S فيه Hemoglobin SC الـC
+
+682
+01:09:14,220 --> 01:09:19,160
+-Hemoglobin نوع لسه آخر على عكس المرضى بيكونوا
+
+683
+01:09:19,160 --> 01:09:24,140
+كويسين إذا فيه Persistence of F-Hemoglobin يعني
+
+684
+01:09:24,140 --> 01:09:28,420
+سبحان اللهكل الأعراض اللي حكيناها للـS-Hemoglobin
+
+685
+01:09:28,420 --> 01:09:33,420
+لما نكون مع الـA بس إذا فيه F وزيادة شويه في الـF
+
+686
+01:09:33,420 --> 01:09:41,440
+الـS بيبطل يسبب مرض يعني في علاقات مع بعض فجزء من
+
+687
+01:09:41,440 --> 01:09:47,220
+الظواهر الـPersistence of Elevated Fetal
+
+688
+01:09:47,220 --> 01:09:52,640
+Hemoglobin Expression يعني في حالاتبدل حتى بعد ما
+
+689
+01:09:52,640 --> 01:09:56,700
+نولد والأصل إن الـF-Hemoglobin يبطل ويتحول للـA
+
+690
+01:09:56,700 --> 01:10:03,320
+-Hemoglobin وبعد شويه يطلع الـA2 هذه ممكن إنها إذا
+
+691
+01:10:03,320 --> 01:10:06,820
+في ضل زيادة أو ارتفاعة الـF-Hemoglobin
+
+692
+01:10:06,820 --> 01:10:10,880
+الـVolumarization الـCrystallization تبع الـS
+
+693
+01:10:10,880 --> 01:10:21,520
+-Hemoglobin بتقلأحسن بالنسبة للـ «سيكلر» ويعني
+
+694
+01:10:21,520 --> 01:10:27,940
+الكلام اللي بحكوه عنه إذا بحطه مثال على إنه الأصل
+
+695
+01:10:27,940 --> 01:10:30,700
+اللي الواحد يشوف الـFeta-Hemoglobin يمشي بهذا
+
+696
+01:10:30,700 --> 01:10:35,300
+الشكل بالذات بعد البرد بتلاقي إنه فيه persistence
+
+697
+01:10:35,300 --> 01:10:41,560
+of F-Hemoglobin ويكون نتيجة هنا اختلال على مستوى
+
+698
+01:10:41,560 --> 01:10:51,570
+الـRNA levelيعني إشي مش بالضرورة مربوط بالـ…
+
+699
+01:10:51,570 --> 01:10:58,230
+مربوط بالـ… يعني الـCoding DNA Anomaly مش Coding
+
+700
+01:10:58,230 --> 01:11:05,610
+DNA، هنا على إشي في الـcontrol على الـDNA
+
+701
+01:11:05,610 --> 01:11:10,650
+Expression، ماشي؟ ففي عندنا Persistence of Fetal
+
+702
+01:11:10,650 --> 01:11:17,240
+Hemoglobinوهذا يعني إله تأثيرات معينة الآن
+
+703
+01:11:17,240 --> 01:11:22,740
+السعادة،
+
+704
+01:11:22,740 --> 01:11:27,400
+أه أحكي فالينا قبل ما ندخل على التلسينية هي هيك
+
+705
+01:11:27,400 --> 01:11:34,200
+حكيت النقاط اللي بديها بالنسبة للـ Sickle Cell أو
+
+706
+01:11:37,110 --> 01:11:41,730
+equalitative في فرط الـquality، hemoglobin-based،
+
+707
+01:11:41,730 --> 01:11:46,510
+آية سعيدة دكتور، في جزئيتي لما حكيت إنه بالمرتفعات
+
+708
+01:11:46,510 --> 01:11:50,150
+بيصير احتمالية إنه يصير الـdeoxygenation أكتر وإن
+
+709
+01:11:50,150 --> 01:11:53,490
+أنا المشكلة عندي في الـsickle cell أنيميا، اللي
+
+710
+01:11:53,490 --> 01:11:56,410
+بالـsickle cell إنه يكون عندي الوجود الـhemoglobin
+
+711
+01:11:56,410 --> 01:12:00,870
+acid اللي هو في هيئة الـdeoxy نعم لأن هو اللي
+
+712
+01:12:00,870 --> 01:12:05,430
+بيكون هو اللي بيعمل الـcrystals و… صحيحما فهمتش
+
+713
+01:12:05,430 --> 01:12:08,730
+أنا إيش بقى بيصير احتمالية الـDX ينقش، الـDX ينقش؟
+
+714
+01:12:08,730 --> 01:12:14,410
+لأ، يعني معناته إنه اللي عنده هاي الـSickles
+
+715
+01:12:14,410 --> 01:12:18,230
+الـHemoglobin بيروحش يعيش على المرتفعات العالية
+
+716
+01:12:18,230 --> 01:12:24,790
+يعني مناطق اللي على المرتفعات يعني بيعيش على إشياء
+
+717
+01:12:24,790 --> 01:12:30,850
+على مستوى سطح البحر يعني مثلًا تقوللي والله الناس
+
+718
+01:12:30,850 --> 01:12:36,180
+اللي عايشين على الـHimalayasفي حد عنده سكل سلة
+
+719
+01:12:36,180 --> 01:12:42,640
+هناك لما أروح أدرسهم بلاقي قليل جدا لأنه مافيش حد
+
+720
+01:12:42,640 --> 01:12:49,460
+يعني عنده سكل ويعني كأنه صار بين قوسين يعني هذه من
+
+721
+01:12:49,460 --> 01:12:53,870
+الظواهراللي الواحد بينتبه لها الانتخاب الطبيعي
+
+722
+01:12:53,870 --> 01:12:59,770
+يعني نتيجة إنه الإنسان عنده ملعق يعني زي ما تقولي
+
+723
+01:12:59,770 --> 01:13:03,810
+اللون
+
+724
+01:13:03,810 --> 01:13:09,730
+الأسمر أو الجلد الأسمر أكتر بقن الشمس فعشان هيك
+
+725
+01:13:09,730 --> 01:13:14,930
+السمار في أفريقيا حوالين خط الاستواق في القطبين
+
+726
+01:13:14,930 --> 01:13:20,080
+مافيش حد أسمر شكل طبيعي بروح كثير فاهمي عليك؟وإذا
+
+727
+01:13:20,080 --> 01:13:24,880
+أبيض وراح على خط الاستواء مثلًا بتلاقي صابه أمراض
+
+728
+01:13:24,880 --> 01:13:32,020
+زي مثلًا cancer of the skin أو بيصير عنده أشياء،
+
+729
+01:13:32,020 --> 01:13:39,080
+شو اسمه؟ ما بيقدرش يعمل adaptation ما بيقدرش يعمل
+
+730
+01:13:39,080 --> 01:13:42,620
+adaptation يعني، أه لأ يعني راح يسببله مرض، فعلى
+
+731
+01:13:42,620 --> 01:13:51,700
+مدى أجيال، على مدىيعني مدى طويل من الذات قبل السفر
+
+732
+01:13:51,700 --> 01:13:57,020
+الطويل وقبل الطب المتقدم والأشياء هذه يعني اللي
+
+733
+01:13:57,020 --> 01:14:03,080
+بيكون عنده cycling يعني إذا في مرض للـ carrier
+
+734
+01:14:03,080 --> 01:14:11,220
+ماشي بيقولوا أنه مع الـ fever بيسيبهم hematuria
+
+735
+01:14:11,220 --> 01:14:16,460
+يعني بيصير عندهمCrystallization بالـ Hemoglobin
+
+736
+01:14:16,460 --> 01:14:21,160
+للـ Carrier مش اللي عنده Disease في الـ Tubules of
+
+737
+01:14:21,160 --> 01:14:25,600
+the kidneys لما يكون عندهم Infection ولا كده لأنه
+
+738
+01:14:25,600 --> 01:14:29,960
+نسبة الـ Oxygen قليل كتير فنسبة الـ
+
+739
+01:14:29,960 --> 01:14:33,580
+Crystallization أكتر في هذا المكان في هذا الوقت
+
+740
+01:14:33,580 --> 01:14:39,840
+بسبب لهم مظهر معين إنه بيصير عندهم مرض آه آه
+
+741
+01:14:42,200 --> 01:14:51,780
+هي كتابة من القرآن الله يعطيك الله الان الموضوع
+
+742
+01:14:51,780 --> 01:15:02,480
+الثاني بدنا نتذكر أنه يعني المبدأ الثاني اللي هو
+
+743
+01:15:02,480 --> 01:15:08,840
+إنه إذا عندي مشكلة في عدد وكمية Normal Alpha أو
+
+744
+01:15:08,840 --> 01:15:16,670
+Beta Chain بدنا نسميه 30فالثلاثيمية هي لما يكون
+
+745
+01:15:16,670 --> 01:15:23,230
+عندي مش qualitative مش خلل في الـquality، لأ خلل
+
+746
+01:15:23,230 --> 01:15:28,350
+في الـquantity، ناشي؟ فالأنواع اللي حكيناها
+
+747
+01:15:28,350 --> 01:15:32,510
+للـBeta وده في Alpha، Beta، هدولة يعني
+
+748
+01:15:32,510 --> 01:15:36,630
+الـHemoglobin Structural Variants لاحظ أنا كلهم
+
+749
+01:15:36,630 --> 01:15:41,250
+Beta Chain يعني مش حاطين مثال على Alpha Chainيكون
+
+750
+01:15:41,250 --> 01:15:49,350
+فيها زي الـSickle، Equalitative الفلسيفية
+
+751
+01:15:49,350 --> 01:15:54,930
+هي لما يكون عندي Abnormalities
+
+752
+01:15:54,930 --> 01:16:02,730
+in the level of the expression of Alpha وBeta
+
+753
+01:16:02,730 --> 01:16:08,110
+chain فهم الـAlpha وBeta normal كـStructure per se
+
+754
+01:16:08,520 --> 01:16:14,080
+بس كعدد و Level فيه Abnormality في عندنا الـ
+
+755
+01:16:14,080 --> 01:16:20,880
+«تلاسيميا» بنقسمهم Alpha و Beta «تلا» ثلاثة
+
+756
+01:16:20,880 --> 01:16:26,580
+«تلاثة» يعني البحر «يميا» Blood يعني كانوا
+
+757
+01:16:26,580 --> 01:16:31,520
+اليونانيين أو كلمة من المصدر اليوناني لدم البحر
+
+758
+01:16:31,520 --> 01:16:37,060
+يعني هيك بدنا ناخدها ويكون يعني جزء منه كما ذكرت
+
+759
+01:16:37,440 --> 01:16:42,500
+الله العليم بفسره رتباطها بالـ Malaria أو يمكن
+
+760
+01:16:42,500 --> 01:16:46,240
+بنقص الأكسجين أو الأكسجين ففي عندنا Beta
+
+761
+01:16:46,240 --> 01:16:52,380
+-thalassemia وفي عندي Alpha-thalassemia، ماشي؟
+
+762
+01:16:52,380 --> 01:17:00,760
+في اللي لما نكون، في عندي إيش اسمه؟ لما نكون عندي
+
+763
+01:17:00,760 --> 01:17:05,120
+Beta-thalassemia، ماشي؟ ويكون عندي Excess of
+
+764
+01:17:05,120 --> 01:17:09,460
+Normal Alpha Chainبسموه إيش بنشوفه تحت الـ
+
+765
+01:17:09,460 --> 01:17:13,720
+Microscope بسموه Heinz Bodies يعني إبارة عن زي هيك
+
+766
+01:17:13,720 --> 01:17:23,700
+نقطة سودة أكتر أو غامقة أكتر في الـ بالنسبة لـ الـ
+
+767
+01:17:23,700 --> 01:17:28,280
+زي الـ Beta-thalassemia الأكثر اللي هم الـ Alpha
+
+768
+01:17:28,280 --> 01:17:36,510
+-thalassemia الـ Alpha-thalassemia هيوهنا Simple
+
+769
+01:17:36,510 --> 01:17:45,590
+Beta-thalassemia يعني هنا زي ما انتوا شايفين فيه
+
+770
+01:17:45,590 --> 01:17:50,110
+عندنا يعني هنا حاطين الـAffected Population
+
+771
+01:17:50,110 --> 01:17:55,910
+الـPlax، الـIndians، الـMediterranean منطقتنا
+
+772
+01:17:55,910 --> 01:18:06,060
+الـAsians، الجبانيين ففيه أكثرمن نوع من الـ
+
+773
+01:18:06,060 --> 01:18:13,540
+Mechanism حتى يعطينا Beta-thalassemia يعني الأكثر
+
+774
+01:18:13,540 --> 01:18:19,520
+أشياء أنه طبعاً يعني الملاحظة كمان نقطة لازم واحد
+
+775
+01:18:19,520 --> 01:18:25,820
+يكون منتبه إليها أنه ممكن عندي أنا Second cell
+
+776
+01:18:25,820 --> 01:18:30,100
+Beta-thalassemia ممكن يصير أو Alpha-thalassemia
+
+777
+01:18:30,590 --> 01:18:35,930
+فعشان هيك يعني بتكون إنه فيه خلالين في نفس الوقت
+
+778
+01:18:35,930 --> 01:18:40,570
+في محالين مختلفان الـ Sickle Cell S-Hemoglobin
+
+779
+01:18:40,570 --> 01:18:46,950
+نتيجة Beta Chain Mutation في مكان معين لإشي معين
+
+780
+01:18:46,950 --> 01:18:52,810
+هذا بيعطينا الـ Beta-Thalassemia الـSLS-Hemoglobin
+
+781
+01:18:52,810 --> 01:18:58,150
+والـBeta-Thalassemia في يعني
+
+782
+01:18:59,300 --> 01:19:05,040
+بالنسبة للـ Beta-thalassemia بشكل عام أشياء مش
+
+783
+01:19:05,040 --> 01:19:10,220
+deletion يعني إذا بتشوفوا شو أنواع المشاكل يعني
+
+784
+01:19:10,220 --> 01:19:15,540
+أنا الشغلات المعقدة مديش أدخل فيها أنا مش حافظها
+
+785
+01:19:15,540 --> 01:19:20,560
+يعني أو مش منتبئلها، شايف عليك؟ بس لاحظوا أهم نقطة
+
+786
+01:19:20,560 --> 01:19:25,680
+إنه مش deletion اللي هي بتوقعوا في الـAlpha
+
+787
+01:19:25,680 --> 01:19:35,240
+-thalassemiaالشغل التاني كنوع Specific للـ Defect
+
+788
+01:19:35,240 --> 01:19:40,120
+في كل نوع من الـ Beta-thalassemia هذا بيحطوا Beta
+
+789
+01:19:40,120 --> 01:19:46,140
+-thalassemia Plus أو Beta Zero Beta Zero بيكون
+
+790
+01:19:46,140 --> 01:19:52,860
+more يعني Severe in the manifestation بيكون درجة
+
+791
+01:19:52,860 --> 01:19:57,680
+الأنيميا، درجة الخلل شديد كثيرفبنكتبوا لكم Beta
+
+792
+01:19:57,680 --> 01:20:05,920
+Plus بيكون أخفر وفي مجال أحسن يعني المريض بيعيش
+
+793
+01:20:05,920 --> 01:20:09,600
+أحسن يعني أو بيكون الـHemoglobin تبعه أحسن أو
+
+794
+01:20:09,600 --> 01:20:15,140
+بعضها almost يعني almost reaching normal، ناشي؟
+
+795
+01:20:15,140 --> 01:20:21,040
+فهدولة يعني بالنسبة للـBeta-thalassemia ممكن ييجي
+
+796
+01:20:21,040 --> 01:20:25,420
+مع الـsickle cell ممكن واحد مصاب بالـCS Hemoglobin
+
+797
+01:20:25,840 --> 01:20:31,660
+والثانية فيها ثلاثينية بشكل اللي هو يؤثر على الـ
+
+798
+01:20:31,660 --> 01:20:35,700
+Level of the gene expression أو البروتين اللي
+
+799
+01:20:35,700 --> 01:20:45,520
+موجود هاي أمثلة عشان الـ Multiple للـ Beta
+
+800
+01:20:45,520 --> 01:20:51,770
+-Thalassinبالنسبة للـ Gram shift نونسينس كودون
+
+801
+01:20:51,770 --> 01:20:56,990
+Unstable Globulin Small Deletion RNA كذا يعني
+
+802
+01:20:56,990 --> 01:21:02,350
+تأثيرات الـ Mutations اللي بتسوي Beta-thalassemia
+
+803
+01:21:02,350 --> 01:21:05,690
+الآن
+
+804
+01:21:05,690 --> 01:21:14,170
+تفاصيلها بدنا أشيها، ناشي؟ بالنسبة للـ Alpha
+
+805
+01:21:14,170 --> 01:21:14,970
+-thalassemia
+
+806
+01:21:17,530 --> 01:21:24,310
+اللي طبعاً حكينا هاي أسف هاي كمان للـ Beta هاي للـ
+
+807
+01:21:24,310 --> 01:21:31,550
+Beta هاي أنواع الـ Eta والـ G Gamma والـ A Gamma
+
+808
+01:21:31,550 --> 01:21:38,010
+وكده وبيحطوا كيف في كل population من الـ Humans في
+
+809
+01:21:38,010 --> 01:21:42,270
+إشي مختلف ليش؟
+
+810
+01:21:50,200 --> 01:22:03,800
+تواني هاي بقول بالنسبة لو افترضنا أنه
+
+811
+01:22:03,800 --> 01:22:14,060
+بقول بالنسبة لقضية المرتفعات لأ هاي الـ «سلايدات»
+
+812
+01:22:14,060 --> 01:22:15,600
+مش كاملة آسف
+
+813
+01:22:18,100 --> 01:22:24,000
+بالنسبة لقضية المرتفعات آخر slide أنا حاطه بس فيه
+
+814
+01:22:24,000 --> 01:22:29,480
+أشياء بعدين ممكن نحكيها ولمرة الجاية برجع بعيد
+
+815
+01:22:29,480 --> 01:22:39,740
+عليها من الأول بالنسبة لقضية أنه يعني يعني
+
+816
+01:22:39,740 --> 01:22:46,500
+محاولة تفسير ليش بعض الأمراض أكتر في بعض الـ
+
+817
+01:22:46,500 --> 01:22:54,990
+populationsفي بعض المجموعات البشرية، ليش؟ شو اسمه؟
+
+818
+01:22:54,990 --> 01:22:59,890
+وقد يكون جزء من الموضوع اللي هي قضية إنه إذا
+
+819
+01:22:59,890 --> 01:23:08,930
+البيئة فيها يعني إذا فيها مظهر معين فيها ميز معين
+
+820
+01:23:08,930 --> 01:23:18,110
+بتفضل أو بتنفر مجموعة معينةفاللي عنده S-Hemoglobin
+
+821
+01:23:18,110 --> 01:23:26,110
+بيحب أو بيقدر أو بتحمل يروح يعيش في المرتفعات راح
+
+822
+01:23:26,110 --> 01:23:32,950
+يقول لأ لأن المرتفعات الأكسيدين فيها أقل الـ21%
+
+823
+01:23:32,950 --> 01:23:36,530
+اللي بتعرفها هذه لنسبة الأكسيدين في الهواء على سطح
+
+824
+01:23:36,530 --> 01:23:42,130
+البحر كل ما تطلع فوق، ماشي، راح تلاقي نسبة
+
+825
+01:23:42,130 --> 01:23:46,980
+الأكسيدين أقلفاحتمالية إن واحد عنده SS hemoglobin
+
+826
+01:23:46,980 --> 01:23:52,960
+يصير عنده attack ويصير عنده crisis أكبر لما يرتفع
+
+827
+01:23:52,960 --> 01:23:58,340
+الواحد على سطح البحر فهي زي ما حكينا كجانب منفر
+
+828
+01:23:58,340 --> 01:24:02,780
+لهذا الميزة يعني على عكس بتعطيه disadvantage
+
+829
+01:24:02,780 --> 01:24:10,380
+بتعطيه ضغط يعني بـ بـ بـ يعني ما بتعطيهوش أفضلية
+
+830
+01:24:10,380 --> 01:24:17,040
+بتعطيهبارد يعني بيحب ينزل على الـ الـ الـ على الـ
+
+831
+01:24:17,040 --> 01:24:20,300
+sea level عشان نسبة الـ Oxygen أكتر وإذا نسبة الـ
+
+832
+01:24:20,300 --> 01:24:25,980
+Oxygen أكتر في الأغوار وفي مكان بـ low sea level
+
+833
+01:24:25,980 --> 01:24:31,700
+أكتر ممكن أنه يكون يحب يروح هناك لأنه بيشوف حاله
+
+834
+01:24:31,700 --> 01:24:37,340
+أحسن بيصيبوش نفس المرض في أي ناحية بالنسبة للـ
+
+835
+01:24:37,340 --> 01:24:43,990
+Alpha Thalassemiaالـ Thalassemia طبعاً يعني إلها
+
+836
+01:24:43,990 --> 01:24:50,150
+برضه عراض كثيرة بالذات يعني فيه slide بما إنه أنا
+
+837
+01:24:50,150 --> 01:24:56,250
+عندي أربعة copies من الـ أربعة copies من الـ Alpha
+
+838
+01:24:56,250 --> 01:25:04,930
+genes ماشي اللي هي Alpha 1 و Alpha 2 عندي أربعة
+
+839
+01:25:04,930 --> 01:25:11,660
+copies والأمر بكون deletionفممكن إنسان الأسان
+
+840
+01:25:11,660 --> 01:25:18,000
+الطبيعي عنده الأربع إذا واحد راح، بكون إش خفيف وما
+
+841
+01:25:18,000 --> 01:25:23,900
+بسويش إشي، بعملش مرض فمن يروح اتنين، بنسميه Alpha
+
+842
+01:25:23,900 --> 01:25:31,860
+Thalassemia Carrier إذا ثلاثة راحل وبظل one copy،
+
+843
+01:25:31,860 --> 01:25:38,840
+بكون يعني Perseveredوبكون الإنسان مصاب
+
+844
+01:25:38,840 --> 01:25:42,980
+بالـClassical Thalassemia الـAlpha اللي هي بتلاقي
+
+845
+01:25:42,980 --> 01:25:46,920
+Short Stature فيه Bossing of the Bones of the Face
+
+846
+01:25:46,920 --> 01:25:51,840
+فيه Hepatosplenomegaly فيه Anemia فيه Hemolysis
+
+847
+01:25:51,840 --> 01:25:57,900
+فيه Aplastic Anemia Tendency فيه مشاكل يعني كثيرة
+
+848
+01:25:57,900 --> 01:26:05,690
+بتصير نتيجة الإنسان اللي عنده Alpha Thalassemiaف…
+
+849
+01:26:05,690 --> 01:26:13,090
+وده أربعة راحوا هذه بيسموه parts hemoglobin
+
+850
+01:26:13,090 --> 01:26:19,090
+وبيكون بس من الـ Beta-chain أربعة Beta-chain برضه
+
+851
+01:26:19,090 --> 01:26:25,410
+severe وبيكون incompatible with life يعني ما بعيش
+
+852
+01:26:25,410 --> 01:26:31,110
+الجنين هذا وبيموت في بطن إما بيسموه Hydroxpetalus
+
+853
+01:26:31,540 --> 01:26:38,880
+وهيكون سبب من أسباب إنه الإنسان هذا بعيشش النقطة
+
+854
+01:26:38,880 --> 01:26:44,700
+الأخيرة، يعني مش غلط، اقرأوها في الكتاب بالذات
+
+855
+01:26:44,700 --> 01:26:50,260
+بالنسبة للـThalassemia يعني الإنسان إنه يطلع مصاب
+
+856
+01:26:50,260 --> 01:26:56,160
+بالـThalassemia مشكلة كبيرة كتير كتير كتير يعني
+
+857
+01:26:56,160 --> 01:27:03,820
+إنسان هويت طفل من الأولهو يتغلب ويغلب أهله ويعيشوا
+
+858
+01:27:03,820 --> 01:27:11,580
+في حياة طبيعية ويكون يعني عنده مشاكل كبيرة
+
+859
+01:27:11,580 --> 01:27:17,800
+الأنيميا، بنضطر نعطيهم دم لما نعطيهم دم، بيصير
+
+860
+01:27:17,800 --> 01:27:21,340
+عندهم Iron Overload بيقولهم الـHepatitis، بيقولهم
+
+861
+01:27:21,340 --> 01:27:26,000
+الـHIV، بيقولهم أمراض بيصير عندهم تكرار
+
+862
+01:27:26,000 --> 01:27:30,420
+الـHemoglobinأو Blood Transfusion بيصير عندهم
+
+863
+01:27:30,420 --> 01:27:37,240
+Immunization فبيصيروا كل مرة وبعدين بيصير أصعب
+
+864
+01:27:37,240 --> 01:27:41,560
+وأصعب تلاقيلهم الدم تبعهم فهي حياة معاناة وغير
+
+865
+01:27:41,560 --> 01:27:49,580
+طبيعية فالملاحظ بالنسبة للثلاثينية ماشي أنه فيه
+
+866
+01:27:49,580 --> 01:27:56,560
+إمكانية التشخيص قبل الأول شيء يعني كثير من الدول
+
+867
+01:27:56,560 --> 01:28:04,060
+وأنظمةبتحط اللي هو الفحص ما قبل الزواج فطبعاً أسهل
+
+868
+01:28:04,060 --> 01:28:07,440
+طريقة أو الطريقة المعتادة مثلا عندنا في الأردن
+
+869
+01:28:07,440 --> 01:28:10,540
+اللي هو بيعملوا الـ Complete Blood Count اللي هو
+
+870
+01:28:10,540 --> 01:28:15,440
+الـCBC بندور لأن حجم الخلايا اللي عندهم
+
+871
+01:28:15,440 --> 01:28:20,400
+Hemoglobinopathy بكون أصغر وضمن مؤشرات أخرى
+
+872
+01:28:20,400 --> 01:28:24,880
+فالـMicrocytosis Indication حتى لو الـHemoglobin
+
+873
+01:28:24,880 --> 01:28:29,650
+normal كlevelنتيجة إنه عدد الخلايا أكبر بس حجمه
+
+874
+01:28:29,650 --> 01:28:33,790
+أصغر حيث إنه بيظل الـ Hemoglobin كويس يعني بس
+
+875
+01:28:33,790 --> 01:28:37,830
+بيكون شويه واضح فبتدلل على إن هذا الإنسان Carrier
+
+876
+01:28:37,830 --> 01:28:41,130
+يعني
+
+877
+01:28:41,130 --> 01:28:45,990
+إحنا الآن من الأمور الروتينية لكل المقبلين على
+
+878
+01:28:45,990 --> 01:28:52,870
+الزواج إنهم الأثنين يفحصوا الزوج والزوجة العريس
+
+879
+01:28:52,870 --> 01:28:58,740
+والعروض وإذا الأثنين عندهم المشكلةبيسيروا يقولوله
+
+880
+01:28:58,740 --> 01:29:04,620
+مروحه لأ على دكتور نقش الموضوع يعني
+
+881
+01:29:04,620 --> 01:29:12,380
+لعساس أنه نحاول أنه نتدخّل قبل ما يعني ييجي الطفل
+
+882
+01:29:12,380 --> 01:29:18,680
+والإنسان هذا فإذا كانوا الأثنين حاملين طبعا إذا
+
+883
+01:29:18,680 --> 01:29:24,760
+إنسان مصابوالتزامر السيسر في الغالب بيكون very
+
+884
+01:29:24,760 --> 01:29:30,160
+severe وما بيعيشش، مابتجوزش، مابقدرش هو بعدين ينقل
+
+885
+01:29:30,160 --> 01:29:38,160
+يعني أما اللي لما نكونه إنسان career فكل ما أقدرنا
+
+886
+01:29:38,160 --> 01:29:44,420
+نمنع زواج الأثنين المصابين بيكون أفضل وأحسن، أثناء
+
+887
+01:29:44,420 --> 01:29:50,350
+اللي بيصير يعني وبعض المجتمعات والدول ممكنبتاخدوا
+
+888
+01:29:50,350 --> 01:29:56,150
+طريق تاني يعني إذا زي ما بيقولوا زواج مدبر يعني
+
+889
+01:29:56,150 --> 01:30:03,690
+عيلة و عيلة الإممايات والآباء اتفقوا لو فحصوا لقوا
+
+890
+01:30:03,690 --> 01:30:10,030
+إنه في عدم تطابق في الغالب لأ ما يعني بيفرقش
+
+891
+01:30:10,030 --> 01:30:14,950
+الجيزة هذه لسبب طبي وبلاش من هالجيزة هذه بالذات
+
+892
+01:30:14,950 --> 01:30:21,200
+يعني ممكن اختار فرض آخر ولا كدهأحياناً المشاكل إذا
+
+893
+01:30:21,200 --> 01:30:26,380
+والله إثنين حبوا بعض وبيلا بدهم يتجوزوا وشوما يكون
+
+894
+01:30:26,380 --> 01:30:31,180
+يكون وشوما كذا بتلاقي هنا بتلاقي فيه صعوبة أخرى
+
+895
+01:30:31,180 --> 01:30:35,080
+يعني اللي هي قضية إن في بعض المجتمعات وبعض الدول
+
+896
+01:30:35,080 --> 01:30:43,060
+بيصيروا يعملوا فحص للـThalassemia عند الحمل، في
+
+897
+01:30:43,060 --> 01:30:49,690
+أول الحمل عشان لو كان الجنين مصابماشي وهذه
+
+898
+01:30:49,690 --> 01:30:55,010
+احتمالية إذا اثنين Carriers ربع وإذا الإنسان يطلع
+
+899
+01:30:55,010 --> 01:30:58,970
+منهم Carrier كمان احتماليته نصف واحتمالية تطلع
+
+900
+01:30:58,970 --> 01:31:03,810
+Completely Normal إذا اتوا Carriers ربع فنتيجة
+
+901
+01:31:03,810 --> 01:31:09,710
+الاحتماليات هذه احتمالية أنه اللي هي الربع أنه
+
+902
+01:31:09,710 --> 01:31:17,570
+يكون الجنين مصاب ففي ناس بعرضوا قضية اللي هيالـ
+
+903
+01:31:17,570 --> 01:31:21,610
+Termination أو الـ Abortion اللي هو الإجهاد إذا
+
+904
+01:31:21,610 --> 01:31:27,370
+كان وفيه الآن يعني بالذات للثلاثيميا لأنه بيعتمد
+
+905
+01:31:27,370 --> 01:31:32,930
+على الـ hematopoietic stem cells و الـ cells تبعات
+
+906
+01:31:32,930 --> 01:31:37,390
+الـ hematopoiesis بيصيروا يعملوا شو بيقولوله يعني؟
+
+907
+01:31:37,390 --> 01:31:41,510
+stem cell transplantation بيحاولوا يغيروا من الـ
+
+908
+01:31:41,510 --> 01:31:47,750
+hemoglobinوفيه يعني إذا بتسمعوا تقنية جديدة في
+
+909
+01:31:47,750 --> 01:31:52,890
+العالم ليه؟ CRISPR-9 اللي هو عبارة عن بروتين بيقدر
+
+910
+01:31:52,890 --> 01:31:57,930
+الواحد إذا بيقدر يحدد وين الجين المصاب يدخل ويعدّه
+
+911
+01:31:57,930 --> 01:32:02,090
+فهي يعني الفكرة إن هاي الـ Hemoglobin Obesity
+
+912
+01:32:02,090 --> 01:32:12,380
+بتعطي challenges للإنسانية والبشرية بحيث إنهيعني
+
+913
+01:32:12,380 --> 01:32:18,880
+في أمور كثيرة تباينات بين الدول في كيف يتعاملوا مع
+
+914
+01:32:18,880 --> 01:32:23,920
+الموضوع هذا في أسئلة؟
+
+915
+01:32:23,920 --> 01:32:27,500
+أتأخرنا
+
+916
+01:32:27,500 --> 01:32:33,580
+في البداية، أتأخرنا شويه بالنهاية وإذا في أسئلة،
+
+917
+01:32:33,580 --> 01:32:40,040
+أيوة سعادة إسألي
+
+918
+01:32:41,680 --> 01:32:46,820
+كان عندي ميوت يا دكتور، بدي أرجع للـ… للـsickle
+
+919
+01:32:46,820 --> 01:32:50,580
+-cell-anemia إن الـmutation تحول لـGlutamine
+
+920
+01:32:50,580 --> 01:32:56,360
+لـValine، تمام؟ ‏- أجل ‏- والـGlutamine تشارج
+
+921
+01:32:56,360 --> 01:33:00,180
+وValine Uncharged لما يصير عندي Uncharged، إيش
+
+922
+01:33:00,180 --> 01:33:03,380
+الفكرة اللي بدها تصير؟ اللي تخلّي الديوكسي والأخبط
+
+923
+01:33:03,380 --> 01:33:08,680
+هي؟ يعني من الأساس، أساس الفكرة ‏- حكيتلك إيها ‏-
+
+924
+01:33:08,680 --> 01:33:13,630
+انت قطع شوية الفترة ‏- أتنالك، أتنالكالـ Glutamine
+
+925
+01:33:13,630 --> 01:33:20,470
+Hydrophilic يعني بيحب الميه ‏- أه، لأنه تشارج ‏-
+
+926
+01:33:20,470 --> 01:33:25,230
+أه، و الثاني Hydrophobic يعني بيحبش الميه تتخبأ من
+
+927
+01:33:25,230 --> 01:33:30,550
+الميه فهذا المكان اللي .. اللي محل ستة هذا سطحي
+
+928
+01:33:30,550 --> 01:33:34,990
+يعني على السطح لما نكون يعني هيك الـ Theory أو هيك
+
+929
+01:33:34,990 --> 01:33:39,710
+التواقع لما نكون الـ Valine هو اللي موجود على
+
+930
+01:33:39,710 --> 01:33:45,130
+السطح و بالذات الـ Deoxyبحبش هاي الـ Status بحبش
+
+931
+01:33:45,130 --> 01:33:51,190
+هذا الوضع فبيحاول كل تنتين ذالين يلسقن بعض عشان
+
+932
+01:33:51,190 --> 01:33:55,690
+يكبوا بعض مايكونوش التنتين على السطح يعني بيصير يـ
+
+933
+01:33:55,690 --> 01:34:01,270
+Clumping بيصير هيك يتجمع مع بعض أقراها
+
+934
+01:34:01,270 --> 01:34:07,010
+و حاولوا يفهميها يعني لأنه يعني زي ما أقول كرة
+
+935
+01:34:07,010 --> 01:34:13,150
+الأصل سطح حملس مثلاًفي جزء منها بيلزق خيتي اللي
+
+936
+01:34:13,150 --> 01:34:18,090
+راح يصير إنه إذا الجزء اللي ملزق على السطح والكورة
+
+937
+01:34:18,090 --> 01:34:22,910
+اللي جنبها عليها برضه أيش بيلزق على السطح الاثنتين
+
+938
+01:34:22,910 --> 01:34:32,610
+بيلزقوا بعض عشان يخبوا بعض هيك بدأت كونها أوي
+
+939
+01:34:32,610 --> 01:34:36,190
+حتى الآن تمام خلاص بحاول أرجعلها من الكتاب كمان
+
+940
+01:34:36,190 --> 01:34:38,990
+يعني و لو واندي أسئلة أكيد هبعتك اليوم يا دكتور
+
+941
+01:34:39,700 --> 01:34:45,240
+أهلا وسهلا، طيب، الله يعطيكم العافية ونشوفكم إن
+
+942
+01:34:45,240 --> 01:34:48,980
+شاء الله يومنا نرجع، في أسئلة ثانية؟ بضالي؟ آه،
+
+943
+01:34:48,980 --> 01:34:53,420
+آه، بضالي، سمحت يعني بقصة إنه اللي هو الـcarrier
+
+944
+01:34:53,420 --> 01:34:57,440
+للـthalassemia بأخر إشي لما حكينا microcyte لما
+
+945
+01:34:57,440 --> 01:35:00,200
+يكون عنده microcytosis بالخلايا حتى لو كان
+
+946
+01:35:00,200 --> 01:35:04,420
+الهيموجلبين كويس ممكن الـcarriers للـthalassemia
+
+947
+01:35:04,420 --> 01:35:07,540
+أو Alpha-thalassemia يكون عنده microcytosis هاي
+
+948
+01:35:08,050 --> 01:35:10,930
+ولا، لازم تكون عندهم الـMicrophibrosis يعني ممكن
+
+949
+01:35:10,930 --> 01:35:16,810
+تكون عندهم المويزة الـCarrier ولا المصاب؟ لأ،
+
+950
+01:35:16,810 --> 01:35:19,550
+الـCarrier بحكي عنه، بحكي عن الـCarrier
+
+951
+01:35:19,550 --> 01:35:26,290
+الـCarrier؟ آه، آه، يعني يتزق من الـإذا أنتم
+
+952
+01:35:26,290 --> 01:35:30,930
+سريريا ماخدتوش أشياء كتيرة الـCBC، الـComplete
+
+953
+01:35:30,930 --> 01:35:38,760
+Blood Count، ماشي؟لما واحد يصير عنده أنيميا أو فيه
+
+954
+01:35:38,760 --> 01:35:43,020
+مشكلة بالنسبة للدم أكتر الشعسبب اللي هو الـ Iron
+
+955
+01:35:43,020 --> 01:35:47,280
+Deficiency Anemia الـ Iron Deficiency Anemia بيكون
+
+956
+01:35:47,280 --> 01:35:52,280
+عنده Microcytosis وAnisocytosis
+
+957
+01:35:52,280 --> 01:35:58,960
+وطبعاً Low Hemoglobin وشو اسمه؟ يعني Microcytic
+
+958
+01:35:58,960 --> 01:36:05,980
+Hypochromic Anemia اللي هويعني الـ MCHC إذا أنت
+
+959
+01:36:05,980 --> 01:36:10,300
+بتشوفي الـ CDC إذا شفتي نتيجة الـ CDC اللي بتطلع
+
+960
+01:36:10,300 --> 01:36:17,800
+من الجهاز فيها معلومات كثيرة الـ Hemoglobin و
+
+961
+01:36:17,800 --> 01:36:24,700
+بعدين الـ MCH اللي هو الـ Main Carboxylic Volume
+
+962
+01:36:24,700 --> 01:36:33,810
+MCD و MCH و MCHC فهي فيه مؤشراتإذا الـ… الـIron
+
+963
+01:36:33,810 --> 01:36:39,510
+Deficiency Anemia الفكرة تبعتها الخلايا بتكون عن
+
+964
+01:36:39,510 --> 01:36:44,670
+تصغر بيكون الإنسان بالأول طبيعي وفيه حجم الخلايا
+
+965
+01:36:44,670 --> 01:36:50,290
+قريب من الطبيعة وطبيعي ففيه تفاوت في حجم الخلايا
+
+966
+01:36:50,290 --> 01:36:54,950
+أما إذا كل الخلايا صغار بنفس الشكل بنفس الحجم
+
+967
+01:36:54,950 --> 01:37:01,340
+مافيش تفاوت بينهم الـRDW رح يكون Normalبس الـ MCV
+
+968
+01:37:01,340 --> 01:37:08,400
+Low عشان الـ Carrier حتى إنه إذا الحجم الخلية صغير
+
+969
+01:37:08,400 --> 01:37:13,420
+ويكون عنده Hemoglobin كويس بيكون عنده Increased
+
+970
+01:37:13,420 --> 01:37:20,500
+number of red blood cells، ماشي؟ فهذا بيتعود، فيه
+
+971
+01:37:20,500 --> 01:37:27,000
+تغيرات معينة إذا إنسان بلاقي مثلا كرات الدم الحمر
+
+972
+01:37:27,730 --> 01:37:32,490
+اللي عادةً مثلًا من 3.5 إلى 5 مليون per cubic
+
+973
+01:37:32,490 --> 01:37:39,890
+millimeter فلما نتسير حوالي 6، 6.5 والـ MCB low
+
+974
+01:37:39,890 --> 01:37:47,130
+والهيمoglobin 12، 13، 11، الجهات الواطي يعني أوطى
+
+975
+01:37:47,130 --> 01:37:52,350
+الطبيعي بقول شبه متأكد إن هذا تلاثيميا ألف
+
+976
+01:37:52,350 --> 01:37:57,940
+تلاثيميا carrier مش مصابالمصاب الـ Hemoglobin
+
+977
+01:37:57,940 --> 01:38:05,700
+بيكون 8، 5، 6، 7، Very Low Low أه بيكون Low فمن
+
+978
+01:38:05,700 --> 01:38:10,060
+الـCBC العادي فبقول
+
+979
+01:38:10,060 --> 01:38:14,640
+بالنسبة لفحص الـCBC العادي ممكن الإشتباه للـAlpha
+
+980
+01:38:14,640 --> 01:38:19,820
+Thalassemia Career State يكون الواحد شبه متأكد إذا
+
+981
+01:38:19,820 --> 01:38:25,690
+الـMCV Normal، لأ مافيش Alpha Thalassemiaطبعًا، دا
+
+982
+01:38:25,690 --> 01:38:29,130
+أكد أخر معلومة يا دكتور، ماعليش طولت علات الـBeta
+
+983
+01:38:29,130 --> 01:38:33,790
+-thalassemia مافيهاش deletion بشكل عام بس في عندي،
+
+984
+01:38:33,790 --> 01:38:39,150
+بس يعني عندي quantity abnormal بطرق
+
+985
+01:38:39,150 --> 01:38:43,590
+أخرى، بغير الـ… بطرق أخرى، بس بيبقى عندي الـAlpha
+
+986
+01:38:43,590 --> 01:38:48,840
+-thalassemia، فيها deletion ما اللي حكيت أنافي
+
+987
+01:38:48,840 --> 01:38:54,120
+أسلحة مش موجودة راح نعرضهم الأسبوع الجاي اللي هو
+
+988
+01:38:54,120 --> 01:38:59,920
+أنه ممكن يلاجي هم أصلا بيكونوا أربع كوبيس من Alpha
+
+989
+01:38:59,920 --> 01:39:04,840
+ممكن يلاجي واحدة رايحة تلاتة أو اثنين أو واحد أو
+
+990
+01:39:04,840 --> 01:39:10,420
+صفر بلافة في كل الاحتمالات واردة كل الاحتمالات
+
+991
+01:39:10,420 --> 01:39:13,780
+واردة الـSevere اللي هم لما يكون عندي تلاتة يعني
+
+992
+01:39:13,780 --> 01:39:15,980
+ممكن يكون رايح عندي تلاتة من Alpha أو أربع من
+
+993
+01:39:15,980 --> 01:39:21,890
+Alpha وما يكونش عندي Alpha خالصحتى أربعة يمكن أن
+
+994
+01:39:21,890 --> 01:39:26,730
+يكون عندي موت للـ fetus في مرحلة شديمية والسبب أنه
+
+995
+01:39:26,730 --> 01:39:31,430
+ماعندي Alpha chance Alpha chance، نعم، صحيح،
+
+996
+01:39:31,430 --> 01:39:34,690
+ماعجبك الله استمع، هيك المعلومات صارت واضحة، يعطيك
+
+997
+01:39:34,690 --> 01:39:40,270
+العافية يا دكتور، يعطيك
+
+998
+01:39:40,270 --> 01:39:45,530
+العافية يا دكتور، الله يسهل يا أمك، يالا السلام
+
+999
+01:39:45,530 --> 01:39:45,830
+عليك
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/1-iWE_Sbnvw_raw.json b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/1-iWE_Sbnvw_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..7f6f983d74ecbd8a41bf345b3bc0f35bf58134d0
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/1-iWE_Sbnvw_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 2768, "start": 3.5, "end": 27.68, "text": "أيه؟ أين راحت؟ اسمع ليني عشان أعمل share screen share screen طيب بسم الله الرحمن الرحيم بالنسبة لـ إن شاء الله محاضرة اليوم", "tokens": [10721, 1829, 3224, 22807, 5551, 9957, 12602, 39319, 2655, 22807, 24525, 2304, 3615, 32239, 22653, 6225, 8592, 7649, 5551, 25957, 1211, 2073, 2568, 2073, 2568, 23032, 1829, 3555, 4724, 38251, 21984, 34892, 5016, 27842, 34892, 5016, 32640, 20666, 1863, 35457, 3660, 5296, 39184, 36145, 13412, 16606, 21984, 3714, 5016, 46958, 25720, 45595, 20498], "avg_logprob": -0.32812500717463317, "compression_ratio": 1.4744525547445255, "no_speech_prob": 1.9073486328125e-06, "words": [{"start": 3.4999999999999973, "end": 4.7, "word": "أيه؟", "probability": 0.581817626953125}, {"start": 4.7, "end": 5.32, "word": " أين", "probability": 0.71630859375}, {"start": 5.32, "end": 7.48, "word": " راحت؟", "probability": 0.8096923828125}, {"start": 7.48, "end": 8.06, "word": " اسمع", "probability": 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637.53, "text": "الـ «طفرة» أو الـ mutation على إنها اتسبب المرض النقطة الأولى، بدل واحد يتذكر إنه «الطفرة» هذه قد تكون باحتمالين إنها تعمل mutation in the coding region يعني في المنطقة المسئولة تماماً عن البروتين اللي ناتج عن الجين هذا", "tokens": [6027, 39184, 4657, 9566, 5172, 25720, 5933, 34051, 2423, 39184, 27960, 15844, 36145, 11296, 1975, 2655, 35457, 3555, 9673, 43042, 28239, 47432, 3660, 16247, 12610, 7578, 12399, 47525, 1211, 36764, 24401, 7251, 2655, 8848, 37983, 36145, 3224, 4657, 6027, 9566, 5172, 25720, 5933, 29538, 12174, 3215, 6055, 30544, 4724, 995, 33753, 2304, 6027, 9957, 36145, 11296, 6055, 25957, 1211, 27960, 294, 264, 17720, 4458, 37495, 22653, 8978, 9673, 1863, 9566, 28671, 9673, 3794, 19986, 12610, 3660, 46811, 10943, 995, 14111, 18871, 2423, 26890, 35473, 9957, 13672, 1829, 8717, 9307, 7435, 18871, 25724, 9957, 23758], "avg_logprob": -0.16077302788433276, "compression_ratio": 1.6531531531531531, "no_speech_prob": 1.9848346710205078e-05, "words": [{"start": 610.67, "end": 611.37, "word": "الـ", "probability": 0.84423828125}, {"start": 611.37, "end": 613.11, "word": " «طفرة»", "probability": 0.7006591796875}, {"start": 613.11, "end": 613.35, "word": " أو", "probability": 0.96240234375}, {"start": 613.35, "end": 613.49, "word": " الـ", "probability": 0.837158203125}, {"start": 613.49, "end": 614.01, "word": " mutation", "probability": 0.436279296875}, {"start": 614.01, "end": 614.93, "word": " على", "probability": 0.56640625}, {"start": 614.93, "end": 615.51, "word": " إنها", "probability": 0.950439453125}, {"start": 615.51, "end": 616.53, "word": " اتسبب", "probability": 0.927734375}, {"start": 616.53, "end": 616.99, "word": " المرض", "probability": 0.993896484375}, {"start": 616.99, "end": 619.09, "word": " النقطة", "probability": 0.9508463541666666}, {"start": 619.09, "end": 620.11, "word": " الأولى،", "probability": 0.9207763671875}, {"start": 620.11, "end": 620.33, "word": " بدل", "probability": 0.45263671875}, {"start": 620.33, "end": 620.59, "word": " واحد", "probability": 0.9931640625}, {"start": 620.59, "end": 621.31, "word": " يتذكر", "probability": 0.9820556640625}, {"start": 621.31, "end": 622.21, "word": " إنه", "probability": 0.78076171875}, {"start": 622.21, "end": 623.09, "word": " «الطفرة»", "probability": 0.8253173828125}, {"start": 623.09, "end": 623.53, "word": " هذه", "probability": 0.96435546875}, {"start": 623.53, "end": 624.47, "word": " قد", "probability": 0.9853515625}, {"start": 624.47, "end": 625.09, "word": " تكون", "probability": 0.992919921875}, {"start": 625.09, "end": 626.63, "word": " باحتمالين", "probability": 0.9358723958333334}, {"start": 626.63, "end": 627.97, "word": " إنها", "probability": 0.9580078125}, {"start": 627.97, "end": 628.83, "word": " تعمل", "probability": 0.9606119791666666}, {"start": 628.83, "end": 629.83, "word": " mutation", "probability": 0.8984375}, {"start": 629.83, "end": 630.39, "word": " in", "probability": 0.8818359375}, {"start": 630.39, "end": 630.57, "word": " the", "probability": 0.904296875}, {"start": 630.57, "end": 630.91, "word": " coding", "probability": 0.95654296875}, {"start": 630.91, "end": 631.55, "word": " region", "probability": 0.9482421875}, {"start": 631.55, "end": 632.39, "word": " يعني", "probability": 0.76318359375}, {"start": 632.39, "end": 632.49, "word": " في", "probability": 0.9677734375}, {"start": 632.49, "end": 633.01, "word": " المنطقة", "probability": 0.9583740234375}, {"start": 633.01, "end": 633.79, "word": " المسئولة", "probability": 0.89970703125}, {"start": 633.79, "end": 634.59, "word": " تماماً", "probability": 0.8973388671875}, {"start": 634.59, "end": 634.91, "word": " عن", "probability": 0.9814453125}, {"start": 634.91, "end": 635.59, "word": " البروتين", "probability": 0.837646484375}, {"start": 635.59, "end": 635.83, "word": " اللي", "probability": 0.739990234375}, {"start": 635.83, "end": 636.49, "word": " ناتج", "probability": 0.9622395833333334}, {"start": 636.49, "end": 636.71, "word": " 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"probability": 0.96728515625}, {"start": 1446.59, "end": 1447.31, "word": " ممكن", "probability": 0.978759765625}, {"start": 1447.31, "end": 1449.37, "word": " أن", "probability": 0.9580078125}, {"start": 1449.37, "end": 1449.37, "word": " يكون", "probability": 0.95703125}, {"start": 1449.37, "end": 1449.37, "word": " هناك", "probability": 0.989013671875}, {"start": 1449.37, "end": 1449.63, "word": " ميكانيزمات", "probability": 0.9523577008928571}, {"start": 1449.63, "end": 1450.95, "word": " باثوجينيتيك", "probability": 0.93359375}, {"start": 1450.95, "end": 1450.95, "word": " أو", "probability": 0.96630859375}, {"start": 1450.95, "end": 1451.11, "word": " م", "probability": 0.9736328125}], "temperature": 1.0}, {"id": 52, "seek": 147967, "start": 1451.97, "end": 1479.67, "text": "الـ ما نقول شو هما الـ الـ Amino Acids اللي هو اسمه الـ Primary Structure بعدين كنا بتحول لSecondary Structure تارشير Structure لQuaternal Structure التشكل الرابعي للبروتين فالـ Folding الأول هو الـ Secondary 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{"start": 2506.83, "end": 2508.45, "word": " ماشي،", "probability": 0.65155029296875}, {"start": 2508.45, "end": 2508.77, "word": " يعني", "probability": 0.9443359375}, {"start": 2508.77, "end": 2510.01, "word": " 147", "probability": 0.93310546875}, {"start": 2510.01, "end": 2510.37, "word": " يعني", "probability": 0.83740234375}, {"start": 2510.37, "end": 2510.83, "word": " بالضبط", "probability": 0.9730224609375}, {"start": 2510.83, "end": 2511.21, "word": " بالضبط", "probability": 0.9432373046875}, {"start": 2511.21, "end": 2511.79, "word": " حاطين", "probability": 0.7008056640625}, {"start": 2511.79, "end": 2513.17, "word": " رقم،", "probability": 0.8953857421875}, {"start": 2513.17, "end": 2513.65, "word": " ماشي", "probability": 0.9615885416666666}, {"start": 2513.65, "end": 2514.61, "word": " 150", "probability": 0.89697265625}, {"start": 2514.61, "end": 2515.33, "word": " Amino", "probability": 0.95263671875}, {"start": 2515.33, "end": 2515.89, "word": " Acid", "probability": 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"probability": 0.9231770833333334}, {"start": 2657.65, "end": 2659.85, "word": " فالـ", "probability": 0.72314453125}, {"start": 2659.85, "end": 2660.53, "word": " hemoglobin", "probability": 0.87744140625}, {"start": 2660.53, "end": 2661.39, "word": " normally", "probability": 0.60302734375}, {"start": 2661.39, "end": 2661.91, "word": " it", "probability": 0.748046875}, {"start": 2661.91, "end": 2662.07, "word": " will", "probability": 0.86572265625}, {"start": 2662.07, "end": 2663.09, "word": " be", "probability": 0.974609375}, {"start": 2663.09, "end": 2664.31, "word": " like", "probability": 0.9248046875}, {"start": 2664.31, "end": 2664.73, "word": " this", "probability": 0.9638671875}, {"start": 2664.73, "end": 2667.11, "word": " طيب،", "probability": 0.8206787109375}, {"start": 2667.11, "end": 2667.49, "word": " لما", "probability": 0.904052734375}, {"start": 2667.49, "end": 2667.81, "word": " نيجي", "probability": 0.932861328125}, {"start": 2667.81, "end": 2668.45, "word": " ندرس", "probability": 0.9925537109375}, {"start": 2668.45, "end": 2669.53, "word": " كيف", "probability": 0.96484375}, {"start": 2669.53, "end": 2671.89, "word": " الجينات", "probability": 0.86328125}, {"start": 2671.89, "end": 2672.87, "word": " بالأول", "probability": 0.9422200520833334}], "temperature": 1.0}, {"id": 95, "seek": 270061, "start": 2673.39, "end": 2700.61, "text": "تبعته بتشتغل الحكاية اللي حكيناها في عندي أنا two الـ hemoglobin molecule فيه له two subunits فيه Alpha وفيه Beta الـ Alpha في أظن الـ Chromosome 16 إذا قريتها بعدين بنلاحظ أنه", "tokens": [2655, 3555, 34268, 3224, 39894, 8592, 2655, 17082, 1211, 21542, 4117, 995, 10632, 13672, 1829, 11331, 4117, 1829, 8315, 11296, 8978, 18871, 16254, 41850, 732, 2423, 39184, 8636, 45841, 13496, 15582, 8978, 3224, 46740, 732, 1422, 409, 1208, 8978, 3224, 20588, 4032, 41185, 3224, 33286, 2423, 39184, 20588, 8978, 5551, 19913, 1863, 2423, 39184, 1721, 40934, 423, 3165, 11933, 15730, 12174, 16572, 2655, 11296, 39182, 9957, 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genes في عندي Alpha-1 و Alpha-2 في عندي الـ Eta هذه الـ أو Zeta أقل Zeta حرف يوناني أو من الأحرف القديمة و أظن Zeta الآن", "tokens": [10721, 19913, 1863, 14739, 29538, 11933, 36081, 995, 2423, 39184, 20588, 12, 4092, 14424, 8978, 43242, 1829, 20588, 12, 16, 4032, 20588, 12, 17, 8978, 43242, 1829, 2423, 39184, 462, 1328, 29538, 2423, 39184, 34051, 1176, 7664, 5551, 4587, 1211, 1176, 7664, 11331, 28480, 7251, 11536, 7649, 1829, 34051, 9154, 16247, 5016, 28480, 25062, 16254, 46007, 4032, 5551, 19913, 1863, 1176, 7664, 6024, 48506], "avg_logprob": -0.37235576923076924, "compression_ratio": 1.455128205128205, "no_speech_prob": 4.410743713378906e-06, "words": [{"start": 2702.31, "end": 2703.31, "word": "أظن", "probability": 0.7854817708333334}, {"start": 2703.31, "end": 2703.45, "word": " أن", "probability": 0.5}, {"start": 2703.45, "end": 2703.61, "word": " هذه", "probability": 0.383056640625}, {"start": 2703.61, "end": 2704.23, "word": " إيتا", "probability": 0.55810546875}, {"start": 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"end": 3255.98, "word": " 4", "probability": 0.8857421875}, {"start": 3255.98, "end": 3256.54, "word": "%", "probability": 0.67529296875}, {"start": 3256.54, "end": 3257.42, "word": " بدل", "probability": 0.93994140625}, {"start": 3257.42, "end": 3257.9, "word": " الـBeta", "probability": 0.85101318359375}, {"start": 3257.9, "end": 3258.3, "word": " Chain", "probability": 0.79638671875}, {"start": 3258.3, "end": 3258.76, "word": " فيه", "probability": 0.64990234375}, {"start": 3258.76, "end": 3259.1, "word": " عندي", "probability": 0.7039794921875}, {"start": 3259.1, "end": 3259.96, "word": " الـDelta", "probability": 0.914794921875}, {"start": 3259.96, "end": 3260.28, "word": " Chain", "probability": 0.978515625}, {"start": 3260.28, "end": 3260.46, "word": " اللي", "probability": 0.9619140625}, {"start": 3260.46, "end": 3260.72, "word": " راح", "probability": 0.93408203125}, {"start": 3260.72, "end": 3261.64, "word": " تعطيني", "probability": 0.8253173828125}, {"start": 3261.64, "end": 3262.38, "word": " الـA2", "probability": 0.9532470703125}, {"start": 3262.38, "end": 3265.8, "word": " فأنا", "probability": 0.87109375}, {"start": 3265.8, "end": 3266.48, "word": " بعتبر", "probability": 0.8626302083333334}, {"start": 3266.48, "end": 3267.28, "word": " هذا", "probability": 0.9794921875}, {"start": 3267.28, "end": 3268.88, "word": " الـSlide", "probability": 0.8021240234375}, {"start": 3268.88, "end": 3269.68, "word": " وهذا", "probability": 0.7752278645833334}, {"start": 3269.68, "end": 3270.36, "word": " الجدول", "probability": 0.9090169270833334}, {"start": 3270.36, "end": 3271.12, "word": " من", "probability": 0.94140625}, {"start": 3271.12, "end": 3271.54, "word": " أهم", "probability": 0.9951171875}, {"start": 3271.54, "end": 3272.3, "word": " الجدول", "probability": 0.9344075520833334}], "temperature": 1.0}, {"id": 116, "seek": 329961, "start": 3272.99, "end": 3299.61, "text": "وهذا بدي إياكم تفهموا الـ Go where one و two و three أو Portland و الأشياء هذه بديش إياها، هي مش مهمة بس علاقات الـ F و الـ A2 و الـ A و الأنواع المختلفة و كيف ثم بيجوا و كيف التطورها في حياة الإنسان أنا باعتبر هذه أهم الجوانب و لازم واحد يكون مذكرها و فاهمها", "tokens": [2407, 3224, 15730, 4724, 16254, 11933, 25528, 24793, 6055, 5172, 16095, 14407, 2423, 39184, 1037, 689, 472, 4032, 732, 4032, 1045, 34051, 25020, 4032, 16247, 8592, 1829, 16606, 29538, 4724, 16254, 8592, 11933, 25528, 11296, 12399, 39896, 37893, 3714, 16095, 3660, 4724, 3794, 11203, 995, 4587, 9307, 2423, 39184, 479, 4032, 2423, 39184, 316, 17, 4032, 2423, 39184, 316, 4032, 16247, 1863, 14407, 3615, 9673, 46456, 46538, 3660, 4032, 9122, 33911, 38637, 2304, 4724, 1829, 7435, 14407, 4032, 9122, 33911, 16712, 9566, 13063, 11296, 8978, 11331, 25528, 3660, 33688, 1863, 3794, 7649, 41850, 4724, 995, 34268, 26890, 29538, 5551, 16095, 25724, 2407, 7649, 3555, 4032, 5296, 31377, 2304, 36764, 24401, 7251, 30544, 3714, 8848, 37983, 11296, 4032, 6156, 995, 16095, 11296], "avg_logprob": 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"probability": 0.811279296875}, {"start": 3281.69, "end": 3282.73, "word": " علاقات", "probability": 0.976318359375}, {"start": 3282.73, "end": 3283.57, "word": " الـ", "probability": 0.884765625}, {"start": 3283.57, "end": 3284.03, "word": " F", "probability": 0.9169921875}, {"start": 3284.03, "end": 3284.47, "word": " و", "probability": 0.76416015625}, {"start": 3284.47, "end": 3284.65, "word": " الـ", "probability": 0.84619140625}, {"start": 3284.65, "end": 3285.11, "word": " A2", "probability": 0.813232421875}, {"start": 3285.11, "end": 3285.47, "word": " و", "probability": 0.97265625}, {"start": 3285.47, "end": 3285.67, "word": " الـ", "probability": 0.95556640625}, {"start": 3285.67, "end": 3285.99, "word": " A", "probability": 0.82763671875}, {"start": 3285.99, "end": 3286.73, "word": " و", "probability": 0.83154296875}, {"start": 3286.73, "end": 3287.87, "word": " الأنواع", "probability": 0.9698486328125}, {"start": 3287.87, "end": 3288.89, "word": " المختلفة", "probability": 0.9967041015625}, {"start": 3288.89, "end": 3289.17, "word": " و", "probability": 0.94970703125}, {"start": 3289.17, "end": 3289.65, "word": " كيف", "probability": 0.901123046875}, {"start": 3289.65, "end": 3289.91, "word": " ثم", "probability": 0.626220703125}, {"start": 3289.91, "end": 3290.59, "word": " بيجوا", "probability": 0.8802490234375}, {"start": 3290.59, "end": 3290.85, "word": " و", "probability": 0.96435546875}, {"start": 3290.85, "end": 3291.45, "word": " كيف", "probability": 0.8486328125}, {"start": 3291.45, "end": 3292.41, "word": " التطورها", "probability": 0.752197265625}, {"start": 3292.41, "end": 3292.55, "word": " في", "probability": 0.98681640625}, {"start": 3292.55, "end": 3292.91, "word": " حياة", "probability": 0.9314778645833334}, {"start": 3292.91, "end": 3293.55, "word": " الإنسان", "probability": 0.9949951171875}, {"start": 3293.55, "end": 3294.17, "word": " أنا", "probability": 0.8955078125}, {"start": 3294.17, "end": 3294.63, "word": " باعتبر", "probability": 0.84210205078125}, {"start": 3294.63, "end": 3294.85, "word": " هذه", "probability": 0.3095703125}, {"start": 3294.85, "end": 3295.45, "word": " أهم", "probability": 0.81591796875}, {"start": 3295.45, "end": 3296.23, "word": " الجوانب", "probability": 0.853271484375}, {"start": 3296.23, "end": 3296.65, "word": " و", "probability": 0.83544921875}, {"start": 3296.65, "end": 3297.01, "word": " لازم", "probability": 0.98193359375}, {"start": 3297.01, "end": 3297.21, "word": " واحد", "probability": 0.978759765625}, {"start": 3297.21, "end": 3297.61, "word": " يكون", "probability": 0.98046875}, {"start": 3297.61, "end": 3298.73, "word": " مذكرها", "probability": 0.7603759765625}, {"start": 3298.73, "end": 3298.89, "word": " و", "probability": 0.97314453125}, {"start": 3298.89, "end": 3299.61, "word": " فاهمها", "probability": 0.9017333984375}], "temperature": 1.0}, {"id": 117, "seek": 333063, "start": 3303.13, "end": 3330.63, "text": "هذه هي الـ Genetic Basis وهنا الناس، يعني We are describing the normal development of Hemoglobin production بيكون على مراحل مختلفة، لأنواع مختلفة، بالجينات مختلفة واللي بنبه عليه أنه يعني تركيب", "tokens": [3224, 24192, 39896, 2423, 39184, 3632, 3532, 5859, 271, 37037, 8315, 2423, 8315, 3794, 12399, 37495, 22653, 492, 366, 16141, 264, 2710, 3250, 295, 18568, 45841, 13496, 4265, 4724, 1829, 30544, 15844, 3714, 23557, 5016, 1211, 3714, 46456, 46538, 3660, 12399, 5296, 33456, 14407, 3615, 3714, 46456, 46538, 3660, 12399, 20666, 7435, 1829, 8315, 2655, 3714, 46456, 46538, 3660, 4032, 6027, 20292, 44945, 3555, 3224, 47356, 14739, 3224, 37495, 22653, 6055, 31747, 1829, 3555], "avg_logprob": -0.2489583420753479, "compression_ratio": 1.4068627450980393, "no_speech_prob": 1.430511474609375e-06, "words": [{"start": 3303.13, "end": 3304.53, "word": "هذه", "probability": 0.832763671875}, {"start": 3304.53, "end": 3305.77, "word": " هي", "probability": 0.92431640625}, {"start": 3305.77, "end": 3306.07, "word": " الـ", "probability": 0.77734375}, {"start": 3306.07, "end": 3306.67, "word": " Genetic", "probability": 0.6468505859375}, {"start": 3306.67, "end": 3307.25, "word": " Basis", "probability": 0.891845703125}, {"start": 3307.25, "end": 3308.85, "word": " وهنا", "probability": 0.874267578125}, {"start": 3308.85, "end": 3309.97, "word": " الناس،", "probability": 0.595123291015625}, {"start": 3309.97, "end": 3310.21, "word": " يعني", "probability": 0.90234375}, {"start": 3310.21, "end": 3310.37, "word": " We", "probability": 0.11578369140625}, {"start": 3310.37, "end": 3310.53, "word": " are", "probability": 0.69677734375}, {"start": 3310.53, "end": 3311.29, "word": " describing", "probability": 0.87255859375}, {"start": 3311.29, "end": 3311.77, "word": " the", "probability": 0.44873046875}, {"start": 3311.77, "end": 3312.41, "word": " normal", "probability": 0.7255859375}, {"start": 3312.41, "end": 3313.85, "word": " development", "probability": 0.9560546875}, {"start": 3313.85, "end": 3314.59, "word": " of", "probability": 0.88525390625}, {"start": 3314.59, "end": 3316.23, "word": " Hemoglobin", "probability": 0.79296875}, {"start": 3316.23, "end": 3317.21, "word": " production", "probability": 0.85791015625}, {"start": 3317.21, "end": 3319.47, "word": " بيكون", "probability": 0.7482096354166666}, {"start": 3319.47, "end": 3320.37, "word": " على", "probability": 0.94775390625}, {"start": 3320.37, "end": 3321.53, "word": " مراحل", "probability": 0.95751953125}, {"start": 3321.53, "end": 3322.43, "word": " مختلفة،", "probability": 0.867236328125}, {"start": 3322.43, "end": 3323.03, "word": " لأنواع", "probability": 0.9747314453125}, {"start": 3323.03, "end": 3323.83, "word": " مختلفة،", "probability": 0.9755859375}, {"start": 3323.83, "end": 3324.45, "word": " بالجينات", "probability": 0.90185546875}, {"start": 3324.45, "end": 3325.43, "word": " مختلفة", "probability": 0.9830322265625}, {"start": 3325.43, "end": 3326.19, "word": " واللي", "probability": 0.7884928385416666}, {"start": 3326.19, "end": 3326.57, "word": " بنبه", "probability": 0.6358235677083334}, {"start": 3326.57, "end": 3326.99, "word": " عليه", "probability": 0.98779296875}, {"start": 3326.99, "end": 3328.13, "word": " أنه", "probability": 0.78759765625}, {"start": 3328.13, "end": 3328.95, "word": " يعني", "probability": 0.6885986328125}, {"start": 3328.95, "end": 3330.63, "word": " تركيب", "probability": 0.8623046875}], "temperature": 1.0}, {"id": 118, "seek": 335602, "start": 3331.24, "end": 3356.02, "text": "كأنه فيه حاجة Controller بمرحلة معينة بيخلّي هذا النوع يطلع بعد شويه اللي بعده وبعد شويه اللي بعده بالنسبة للـ Beta-Chain النوع الأول بشكل معين بعدين النوع التاني وبعدين النوع التالف، بهذا الشكل يعني أن الأصل أنه في كل مرحلة بتلاقي نوعية معينة من الـHemoglobin لازم تطلع", "tokens": [4117, 33456, 3224, 8978, 3224, 11331, 26108, 3660, 44969, 4724, 29973, 5016, 37977, 20449, 9957, 3660, 4724, 1829, 9778, 1211, 11703, 1829, 23758, 28239, 45367, 7251, 9566, 1211, 3615, 39182, 13412, 45865, 3224, 13672, 1829, 39182, 3224, 46599, 22488, 13412, 45865, 3224, 13672, 1829, 39182, 3224, 20666, 1863, 35457, 3660, 24976, 39184, 33286, 12, 6546, 491, 28239, 45367, 16247, 12610, 4724, 8592, 28820, 20449, 9957, 39182, 9957, 28239, 45367, 16712, 7649, 1829, 46599, 22488, 9957, 28239, 45367, 16712, 6027, 5172, 12399, 39627, 15730, 25124, 28820, 37495, 22653, 14739, 16247, 36520, 14739, 3224, 8978, 28242, 3714, 2288, 5016, 37977, 39894, 15040, 38436, 8717, 45367, 10632, 20449, 9957, 3660, 9154, 2423, 39184, 39, 443, 45841, 13496, 5296, 31377, 2304, 6055, 9566, 1211, 3615], "avg_logprob": -0.14241803132119726, "compression_ratio": 1.949579831932773, "no_speech_prob": 3.159046173095703e-06, "words": [{"start": 3331.24, "end": 3331.74, "word": "كأنه", "probability": 0.8688151041666666}, {"start": 3331.74, "end": 3332.08, "word": " فيه", "probability": 0.846923828125}, {"start": 3332.08, "end": 3332.52, "word": " حاجة", "probability": 0.9908854166666666}, {"start": 3332.52, "end": 3333.22, 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3566.76, "word": " بيكون", "probability": 0.9007161458333334}, {"start": 3566.76, "end": 3567.14, "word": " لازم", "probability": 0.990234375}, {"start": 3567.14, "end": 3567.52, "word": " يكره", "probability": 0.9768880208333334}, {"start": 3567.52, "end": 3568.0, "word": " الميه", "probability": 0.9402669270833334}, {"start": 3568.0, "end": 3568.24, "word": " حتى", "probability": 0.90869140625}, {"start": 3568.24, "end": 3568.7, "word": " يظلوا", "probability": 0.7742919921875}, {"start": 3568.7, "end": 3569.02, "word": " جوا", "probability": 0.959716796875}, {"start": 3569.02, "end": 3570.34, "word": " ويكونوا", "probability": 0.64251708984375}, {"start": 3570.34, "end": 3570.68, "word": " جوا", "probability": 0.857421875}, {"start": 3570.68, "end": 3571.12, "word": " عشان", "probability": 0.8670247395833334}, {"start": 3571.12, "end": 3572.02, "word": " مايتعرضش", "probability": 0.862109375}, {"start": 3572.02, "end": 3572.72, "word": " للميه", "probability": 0.8779296875}, {"start": 3572.72, "end": 3574.28, "word": " فنتيجة", "probability": 0.830615234375}, {"start": 3574.28, "end": 3576.14, "word": " الاختلال", "probability": 0.8794921875}, {"start": 3576.14, "end": 3576.68, "word": " هذا", "probability": 0.97509765625}, {"start": 3576.68, "end": 3577.44, "word": " من", "probability": 0.97802734375}, {"start": 3577.44, "end": 3578.96, "word": " Hydrophilic", "probability": 0.912109375}, {"start": 3578.96, "end": 3579.58, "word": " على", "probability": 0.822265625}, {"start": 3579.58, "end": 3580.58, "word": " Hydrophobic", "probability": 0.90771484375}, {"start": 3580.58, "end": 3581.3, "word": " على", "probability": 0.9345703125}, {"start": 3581.3, "end": 3581.78, "word": " position", "probability": 0.794921875}, {"start": 3581.78, "end": 3582.6, "word": " معين", "probability": 0.983154296875}, {"start": 3582.6, "end": 3584.1, "word": " تصير", "probability": 0.77783203125}, {"start": 3584.1, "end": 3585.0, "word": " إنه", "probability": 0.60302734375}, {"start": 3585.0, "end": 3586.88, "word": " الـHemoglobin", "probability": 0.8686930338541666}, {"start": 3586.88, "end": 3587.48, "word": " الـS", "probability": 0.74267578125}], "temperature": 1.0}, {"id": 127, "seek": 361753, "start": 3588.23, "end": 3617.53, "text": "في حالة لما يكون Oxygenated Hemoglobin في الـRed Blood Cell بتكون الـHemoglobin موليكيولز يتسفرد بالشكل الطبيعي في حالة الـDeoxyhemoglobin ماشي، لما يبطل ويقل نسبة الأكسجين ويتحول إلى Deoxy الـHydrophobic يعني الـPatch كانت تخيل عند الكرافة", "tokens": [41185, 11331, 6027, 3660, 5296, 15042, 7251, 30544, 16489, 8647, 770, 18568, 45841, 13496, 8978, 2423, 39184, 20544, 17428, 28859, 39894, 30544, 2423, 39184, 39, 443, 45841, 13496, 3714, 12610, 1829, 4117, 1829, 12610, 11622, 7251, 2655, 3794, 5172, 2288, 3215, 20666, 8592, 28820, 41950, 21292, 3615, 1829, 8978, 11331, 6027, 3660, 2423, 39184, 11089, 5230, 88, 28005, 45841, 13496, 3714, 33599, 1829, 12399, 5296, 15042, 7251, 3555, 9566, 1211, 4032, 1829, 4587, 1211, 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"word": " الـRed", "probability": 0.77880859375}, {"start": 3592.73, "end": 3593.05, "word": " Blood", "probability": 0.74560546875}, {"start": 3593.05, "end": 3594.05, "word": " Cell", "probability": 0.9228515625}, {"start": 3594.05, "end": 3594.83, "word": " بتكون", "probability": 0.638916015625}, {"start": 3594.83, "end": 3596.05, "word": " الـHemoglobin", "probability": 0.8865559895833334}, {"start": 3596.05, "end": 3597.33, "word": " موليكيولز", "probability": 0.6709333147321429}, {"start": 3597.33, "end": 3598.07, "word": " يتسفرد", "probability": 0.57244873046875}, {"start": 3598.07, "end": 3598.57, "word": " بالشكل", "probability": 0.9402669270833334}, {"start": 3598.57, "end": 3599.31, "word": " الطبيعي", "probability": 0.9891357421875}, {"start": 3599.31, "end": 3600.47, "word": " في", "probability": 0.84765625}, {"start": 3600.47, "end": 3601.09, "word": " حالة", "probability": 0.99853515625}, {"start": 3601.09, "end": 3602.99, "word": " الـDeoxyhemoglobin", "probability": 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"word": " الـPatch", "probability": 0.531219482421875}, {"start": 3615.17, "end": 3615.81, "word": " كانت", "probability": 0.76806640625}, {"start": 3615.81, "end": 3616.31, "word": " تخيل", "probability": 0.7714029947916666}, {"start": 3616.31, "end": 3616.79, "word": " عند", "probability": 0.7060546875}, {"start": 3616.79, "end": 3617.53, "word": " الكرافة", "probability": 0.49566650390625}], "temperature": 1.0}, {"id": 128, "seek": 364472, "start": 3618.32, "end": 3644.72, "text": "الأصل الكورات تضربوا بعض وما يكونش فيها أي شيء لأ الكورة اتغيرت بحيث أنه على قطعة منها أو على جانب معين صار إشي بلزق صار إشي sticky فلما يصير ديوكسيهيمoglobin المنطقة اللي بتلزق هذه بتبين أكتر وبتكون أكتر وبنتج عنها أنها بتتجمع في", "tokens": [6027, 10721, 36520, 33251, 13063, 9307, 6055, 11242, 25513, 14407, 45030, 11242, 4032, 15042, 7251, 30544, 8592, 8978, 11296, 36632, 44049, 38207, 5296, 10721, 33251, 13063, 3660, 1975, 2655, 17082, 13546, 2655, 4724, 5016, 1829, 12984, 14739, 3224, 15844, 12174, 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3627.52, "end": 3627.94, "word": " منها", "probability": 0.99462890625}, {"start": 3627.94, "end": 3628.22, "word": " أو", "probability": 0.97705078125}, {"start": 3628.22, "end": 3628.44, "word": " على", "probability": 0.89111328125}, {"start": 3628.44, "end": 3628.9, "word": " جانب", "probability": 0.9977213541666666}, {"start": 3628.9, "end": 3629.32, "word": " معين", "probability": 0.98779296875}, {"start": 3629.32, "end": 3629.78, "word": " صار", "probability": 0.967529296875}, {"start": 3629.78, "end": 3630.22, "word": " إشي", "probability": 0.7132975260416666}, {"start": 3630.22, "end": 3630.9, "word": " بلزق", "probability": 0.81939697265625}, {"start": 3630.9, "end": 3631.42, "word": " صار", "probability": 0.840576171875}, {"start": 3631.42, "end": 3632.08, "word": " إشي", "probability": 0.99072265625}, {"start": 3632.08, "end": 3632.66, "word": " sticky", "probability": 0.6708984375}, {"start": 3632.66, "end": 3635.2, "word": " فلما", "probability": 0.7869466145833334}, {"start": 3635.2, "end": 3635.56, "word": " يصير", "probability": 0.9085286458333334}, {"start": 3635.56, "end": 3636.9, "word": " ديوكسيهيمoglobin", "probability": 0.666455078125}, {"start": 3636.9, "end": 3638.64, "word": " المنطقة", "probability": 0.943359375}, {"start": 3638.64, "end": 3638.8, "word": " اللي", "probability": 0.957763671875}, {"start": 3638.8, "end": 3639.32, "word": " بتلزق", "probability": 0.979248046875}, {"start": 3639.32, "end": 3639.58, "word": " هذه", "probability": 0.6982421875}, {"start": 3639.58, "end": 3640.22, "word": " بتبين", "probability": 0.8030598958333334}, {"start": 3640.22, "end": 3640.72, "word": " أكتر", "probability": 0.9530029296875}, {"start": 3640.72, "end": 3641.2, "word": " وبتكون", "probability": 0.726806640625}, {"start": 3641.2, "end": 3641.9, "word": " أكتر", "probability": 0.9949951171875}, {"start": 3641.9, "end": 3642.7, "word": " وبنتج", "probability": 0.8074544270833334}, {"start": 3642.7, "end": 3643.06, "word": " عنها", "probability": 0.982666015625}, {"start": 3643.06, "end": 3643.38, "word": " أنها", "probability": 0.760986328125}, {"start": 3643.38, "end": 3644.22, "word": " بتتجمع", "probability": 0.9451171875}, {"start": 3644.22, "end": 3644.72, "word": " في", "probability": 0.9853515625}], "temperature": 1.0}, {"id": 129, "seek": 367140, "start": 3645.3, "end": 3671.4, "text": "يعني كريستال يعني على شكل بلورة هي إشي كبير وإشي يعني صلب فالأصل الخلية الـ Red blood cells اللي هي Biconcave بهذا الشكل easily deformable يعني", "tokens": [40228, 22653, 9122, 16572, 14851, 6027, 37495, 22653, 15844, 13412, 28820, 4724, 1211, 13063, 3660, 39896, 11933, 8592, 1829, 9122, 3555, 13546, 4032, 28814, 8592, 1829, 37495, 22653, 20328, 46152, 6156, 6027, 10721, 36520, 33962, 1211, 10632, 2423, 39184, 4477, 3390, 5438, 13672, 1829, 39896, 363, 299, 266, 50126, 39627, 15730, 25124, 28820, 3612, 36094, 712, 37495, 22653], "avg_logprob": -0.24073093270851395, "compression_ratio": 1.4025157232704402, "no_speech_prob": 5.960464477539062e-07, "words": [{"start": 3645.3, "end": 3646.94, "word": "يعني", "probability": 0.836669921875}, {"start": 3646.94, "end": 3647.68, "word": " كريستال", "probability": 0.78125}, {"start": 3647.68, "end": 3648.18, "word": " يعني", "probability": 0.697021484375}, {"start": 3648.18, "end": 3648.4, "word": " على", "probability": 0.95703125}, {"start": 3648.4, "end": 3648.92, "word": " شكل", "probability": 0.9814453125}, {"start": 3648.92, "end": 3650.02, "word": " بلورة", "probability": 0.7835693359375}, {"start": 3650.02, "end": 3650.22, "word": " هي", "probability": 0.57373046875}, {"start": 3650.22, "end": 3650.78, "word": " إشي", "probability": 0.8722330729166666}, {"start": 3650.78, "end": 3651.48, "word": " كبير", "probability": 0.9871419270833334}, {"start": 3651.48, "end": 3652.92, "word": " وإشي", "probability": 0.951904296875}, {"start": 3652.92, "end": 3655.48, "word": " يعني", "probability": 0.92138671875}, {"start": 3655.48, "end": 3657.6, "word": " صلب", "probability": 0.89013671875}, {"start": 3657.6, "end": 3660.58, "word": " فالأصل", "probability": 0.74151611328125}, {"start": 3660.58, "end": 3663.08, "word": " الخلية", "probability": 0.9274088541666666}, {"start": 3663.08, "end": 3663.98, "word": " الـ", "probability": 0.87451171875}, {"start": 3663.98, "end": 3664.96, "word": " Red", "probability": 0.494384765625}, {"start": 3664.96, "end": 3665.28, "word": " blood", "probability": 0.419921875}, {"start": 3665.28, "end": 3665.8, "word": " cells", "probability": 0.8447265625}, {"start": 3665.8, "end": 3666.22, "word": " اللي", "probability": 0.943603515625}, {"start": 3666.22, "end": 3666.48, "word": " هي", "probability": 0.89111328125}, {"start": 3666.48, "end": 3667.44, "word": " Biconcave", "probability": 0.58026123046875}, {"start": 3667.44, "end": 3667.82, "word": " بهذا", "probability": 0.75341796875}, {"start": 3667.82, "end": 3668.36, "word": " الشكل", "probability": 0.994140625}, {"start": 3668.36, "end": 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"end": 3754.45, "text": "الـ نتيجة الـ hemoglobinopathies نتيجة الـ qualitative qualitative في عندي أكثر من نوع بس ده يعني أنا إذا بتذكر الـ hemoglobin S وتفاصيله بيكفي في الـ hemoglobin Hammersmith بيسوي Hemolysis وبكون له Oxygen Affinity", "tokens": [6027, 39184, 8717, 31371, 7435, 3660, 2423, 39184, 8636, 45841, 13496, 27212, 530, 8717, 31371, 7435, 3660, 2423, 39184, 31312, 31312, 8978, 18871, 16254, 5551, 4117, 49115, 9154, 8717, 45367, 4724, 3794, 11778, 3224, 37495, 22653, 41850, 11933, 15730, 39894, 8848, 37983, 2423, 39184, 8636, 45841, 13496, 318, 34683, 5172, 33546, 26895, 3224, 4724, 1829, 4117, 41185, 8978, 2423, 39184, 8636, 45841, 13496, 34842, 433, 41708, 4724, 1829, 3794, 45865, 18568, 16453, 17122, 46599, 30544, 46740, 16489, 8647, 12840, 11540], "avg_logprob": -0.29031635802469136, "compression_ratio": 1.5384615384615385, "no_speech_prob": 1.7881393432617188e-06, "words": [{"start": 3724.63, "end": 3725.43, "word": "الـ", "probability": 0.515625}, {"start": 3725.43, 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أسباب أن المريض عنده ذرقاق «كمسي» اللي هو polycythemia «هيموجلوبين E» بيعطينا mild thalassemia فالـ «هيموجلوبين S» هي mutation", "tokens": [3555, 30544, 18871, 16254, 4657, 2655, 17082, 1829, 13546, 5933, 3714, 46456, 46538, 4657, 3224, 32640, 29245, 1211, 37746, 9957, 8032, 995, 36081, 3555, 9640, 3215, 5933, 34051, 4657, 3224, 32640, 29245, 1211, 37746, 9957, 376, 5933, 4724, 1829, 38251, 9957, 3224, 4724, 1829, 30544, 18871, 16254, 4657, 3794, 1829, 7649, 41779, 3794, 5933, 3714, 33599, 1829, 12399, 5551, 24401, 5551, 35457, 16758, 14739, 9673, 16572, 11242, 43242, 3224, 29910, 2288, 4587, 995, 4587, 4657, 24793, 3794, 1829, 5933, 13672, 1829, 31439, 6754, 1344, 392, 14058, 4657, 3224, 32640, 29245, 1211, 37746, 9957, 462, 5933, 4724, 40228, 9566, 1829, 8315, 15154, 258, 304, 8604, 29958, 6156, 6027, 39184, 4657, 3224, 32640, 29245, 1211, 37746, 9957, 318, 5933, 39896, 27960], "avg_logprob": -0.300781241307656, "compression_ratio": 1.751131221719457, "no_speech_prob": 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شوية", "probability": 0.8976236979166666}, {"start": 3999.68, "end": 4001.88, "word": " الـHemoglobin", "probability": 0.9261067708333334}, {"start": 4001.88, "end": 4002.3, "word": " S", "probability": 0.52001953125}, {"start": 4002.3, "end": 4002.84, "word": " طبعاً", "probability": 0.9453125}, {"start": 4002.84, "end": 4003.16, "word": " إله", "probability": 0.5032958984375}, {"start": 4003.16, "end": 4003.98, "word": " أنواع", "probability": 0.9837239583333334}, {"start": 4003.98, "end": 4004.92, "word": " يعني", "probability": 0.930419921875}], "temperature": 1.0}, {"id": 142, "seek": 402532, "start": 4005.68, "end": 4025.32, "text": "ممكن إنسان يكون Carrier يعني نص اللي عنده Hemoglobin S ونصها اللي عنده Disease اللي بنسميه يعني مريض بالـ Sickness and Anemia اللي بيكون عنده SS Hemoglobin يعني الـTintin اللي عنده SA", "tokens": [2304, 43020, 36145, 3794, 7649, 7251, 30544, 2741, 7326, 37495, 22653, 8717, 9381, 13672, 1829, 43242, 3224, 18568, 45841, 13496, 318, 4032, 1863, 9381, 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"probability": 0.95458984375}, {"start": 4010.62, "end": 4011.12, "word": " عنده", "probability": 0.9853515625}, {"start": 4011.12, "end": 4011.8, "word": " Hemoglobin", "probability": 0.8429361979166666}, {"start": 4011.8, "end": 4012.2, "word": " S", "probability": 0.68310546875}, {"start": 4012.2, "end": 4013.42, "word": " ونصها", "probability": 0.926513671875}, {"start": 4013.42, "end": 4013.94, "word": " اللي", "probability": 0.975341796875}, {"start": 4013.94, "end": 4014.3, "word": " عنده", "probability": 0.989501953125}, {"start": 4014.3, "end": 4014.84, "word": " Disease", "probability": 0.6806640625}, {"start": 4014.84, "end": 4015.22, "word": " اللي", "probability": 0.970458984375}, {"start": 4015.22, "end": 4016.28, "word": " بنسميه", "probability": 0.8775634765625}, {"start": 4016.28, "end": 4016.52, "word": " يعني", "probability": 0.635009765625}, {"start": 4016.52, "end": 4016.92, "word": " مريض", "probability": 0.9737955729166666}, {"start": 4016.92, "end": 4017.1, "word": " بالـ", "probability": 0.75439453125}, {"start": 4017.1, "end": 4017.44, "word": " Sickness", "probability": 0.626953125}, {"start": 4017.44, "end": 4017.76, "word": " and", "probability": 0.206298828125}, {"start": 4017.76, "end": 4018.46, "word": " Anemia", "probability": 0.875732421875}, {"start": 4018.46, "end": 4019.24, "word": " اللي", "probability": 0.9853515625}, {"start": 4019.24, "end": 4019.64, "word": " بيكون", "probability": 0.8536783854166666}, {"start": 4019.64, "end": 4020.78, "word": " عنده", "probability": 0.992919921875}, {"start": 4020.78, "end": 4022.02, "word": " SS", "probability": 0.8662109375}, {"start": 4022.02, "end": 4023.14, "word": " Hemoglobin", "probability": 0.8714192708333334}, {"start": 4023.14, "end": 4023.36, "word": " يعني", "probability": 0.803466796875}, {"start": 4023.36, "end": 4024.18, "word": " الـTintin", "probability": 0.533984375}, {"start": 4024.18, "end": 4024.64, "word": " اللي", "probability": 0.878662109375}, {"start": 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" Carrier", "probability": 0.754150390625}, {"start": 4035.22, "end": 4035.88, "word": " بيكون", "probability": 0.7660319010416666}, {"start": 4035.88, "end": 4036.68, "word": " أحسن", "probability": 0.9915771484375}, {"start": 4036.68, "end": 4037.9, "word": " الـ", "probability": 0.9423828125}, {"start": 4037.9, "end": 4038.32, "word": " Carrier", "probability": 0.929443359375}, {"start": 4038.32, "end": 4039.52, "word": " بالذات", "probability": 0.90283203125}, {"start": 4039.52, "end": 4039.98, "word": " للـ", "probability": 0.9345703125}, {"start": 4039.98, "end": 4040.56, "word": " Hemoglobin", "probability": 0.86474609375}, {"start": 4040.56, "end": 4040.9, "word": " S", "probability": 0.65380859375}, {"start": 4040.9, "end": 4041.22, "word": " الـ", "probability": 0.82958984375}, {"start": 4041.22, "end": 4041.62, "word": " Carrier", "probability": 0.77734375}, {"start": 4041.62, "end": 4042.22, "word": " State", "probability": 0.869140625}, {"start": 4042.22, "end": 4043.12, "word": " في", "probability": 0.8193359375}, {"start": 4043.12, "end": 4044.0, "word": " كلام", "probability": 0.76611328125}, {"start": 4044.0, "end": 4044.66, "word": " كتير", "probability": 0.94677734375}, {"start": 4044.66, "end": 4044.9, "word": " على", "probability": 0.83251953125}, {"start": 4044.9, "end": 4045.26, "word": " إن", "probability": 0.64111328125}, {"start": 4045.26, "end": 4046.48, "word": " هؤلاء", "probability": 0.69293212890625}, {"start": 4046.48, "end": 4047.78, "word": " الناس", "probability": 0.9874674479166666}, {"start": 4047.78, "end": 4049.06, "word": " النتيجة", "probability": 0.85858154296875}, {"start": 4049.06, "end": 4049.2, "word": " إن", "probability": 0.712890625}, {"start": 4049.2, "end": 4049.44, "word": " الـ", "probability": 0.765380859375}, {"start": 4049.44, "end": 4050.08, "word": " Hemoglobin", "probability": 0.9431966145833334}, {"start": 4050.08, "end": 4050.72, "word": " S", "probability": 0.95703125}, {"start": 4050.72, "end": 4052.16, "word": " بيكونوا", "probability": 0.7705078125}, {"start": 4052.16, "end": 4052.64, "word": " resistant", "probability": 0.4931640625}, {"start": 4052.64, "end": 4052.96, "word": " to", "probability": 0.88330078125}, {"start": 4052.96, "end": 4053.38, "word": " malaria", "probability": 0.7978515625}], "temperature": 1.0}, {"id": 144, "seek": 407905, "start": 4054.23, "end": 4079.05, "text": "عشان هيك يعني كملاحظة إذا بتسوي هيك الـ Mapping في العالم للمرضى اللي عندهم Sickle Cell S-Hemoglobin والملاريا بتلاقيهم أشياء مع بعض يعني منطقة حوض البحر اللي قدرهم توصل في أفريقيا في أماكن معينة وإما بتشوف فيه ملاريا كتير بتلاقي نسبة الـHemoglobin S أكتر", "tokens": [3615, 8592, 7649, 39896, 4117, 37495, 22653, 9122, 2304, 15040, 5016, 19913, 3660, 11933, 15730, 39894, 3794, 45865, 39896, 4117, 2423, 39184, 376, 10534, 8978, 18863, 45340, 5296, 19528, 43042, 7578, 13672, 1829, 43242, 16095, 43471, 306, 28859, 318, 12, 39, 443, 45841, 13496, 4032, 45340, 1211, 9640, 25528, 39894, 15040, 38436, 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"probability": 0.7421875}, {"start": 4064.03, "end": 4064.93, "word": "-Hemoglobin", "probability": 0.8478515625}, {"start": 4064.93, "end": 4066.27, "word": " والملاريا", "probability": 0.73935546875}, {"start": 4066.27, "end": 4067.45, "word": " بتلاقيهم", "probability": 0.847900390625}, {"start": 4067.45, "end": 4067.89, "word": " أشياء", "probability": 0.8907470703125}, {"start": 4067.89, "end": 4068.09, "word": " مع", "probability": 0.99365234375}, {"start": 4068.09, "end": 4068.57, "word": " بعض", "probability": 0.994384765625}, {"start": 4068.57, "end": 4069.29, "word": " يعني", "probability": 0.9228515625}, {"start": 4069.29, "end": 4069.81, "word": " منطقة", "probability": 0.978515625}, {"start": 4069.81, "end": 4070.23, "word": " حوض", "probability": 0.80517578125}, {"start": 4070.23, "end": 4070.57, "word": " البحر", "probability": 0.9817708333333334}, {"start": 4070.57, "end": 4070.67, "word": " اللي", "probability": 0.97265625}, {"start": 4070.67, "end": 4071.01, "word": " 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4077.01, "word": " بتلاقي", "probability": 0.9134114583333334}, {"start": 4077.01, "end": 4077.51, "word": " نسبة", "probability": 0.9923502604166666}, {"start": 4077.51, "end": 4078.31, "word": " الـHemoglobin", "probability": 0.8734130859375}, {"start": 4078.31, "end": 4078.57, "word": " S", "probability": 0.89599609375}, {"start": 4078.57, "end": 4079.05, "word": " أكتر", "probability": 0.982177734375}], "temperature": 1.0}, {"id": 145, "seek": 410931, "start": 4079.83, "end": 4109.31, "text": "ففي ناس يعني في نظرية لكل واحد دقيق إن الـ S-Hemoglobin بيعطي نوع من الـ Resistance للملاريا وفي يعني كلام على إنه لأ لأن الـ Hemoglobin S المشكلة تبعته لما يكون D-Oxyhemoglobin S أما لما يكون Oxyhemoglobin S مش مشكلة كتير يعني إنه على", "tokens": [5172, 41185, 8717, 32277, 37495, 22653, 8978, 8717, 19913, 2288, 10632, 5296, 28820, 36764, 24401, 11778, 38436, 4587, 36145, 2423, 39184, 318, 12, 39, 443, 45841, 13496, 4724, 40228, 9566, 1829, 8717, 45367, 9154, 2423, 39184, 45647, 5296, 19528, 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4100.09, "word": " تبعته", "probability": 0.9031982421875}, {"start": 4100.09, "end": 4100.27, "word": " لما", "probability": 0.865478515625}, {"start": 4100.27, "end": 4100.61, "word": " يكون", "probability": 0.904541015625}, {"start": 4100.61, "end": 4100.83, "word": " D", "probability": 0.4326171875}, {"start": 4100.83, "end": 4101.81, "word": "-Oxyhemoglobin", "probability": 0.8666178385416666}, {"start": 4101.81, "end": 4102.17, "word": " S", "probability": 0.8583984375}, {"start": 4102.17, "end": 4102.87, "word": " أما", "probability": 0.59466552734375}, {"start": 4102.87, "end": 4103.07, "word": " لما", "probability": 0.906494140625}, {"start": 4103.07, "end": 4103.61, "word": " يكون", "probability": 0.972412109375}, {"start": 4103.61, "end": 4105.01, "word": " Oxyhemoglobin", "probability": 0.860546875}, {"start": 4105.01, "end": 4105.45, "word": " S", "probability": 0.96044921875}, {"start": 4105.45, "end": 4106.03, "word": " مش", "probability": 0.71484375}, {"start": 4106.03, 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الـHemoglobin S فيه Hemoglobin SC الـC-Hemoglobin نوع لسه آخر على عكس المرضى بيكونوا كويسين إذا فيه Persistence of F-Hemoglobin يعني سبحان الله", "tokens": [5172, 41185, 18871, 16254, 5551, 4117, 2655, 2288, 9154, 8717, 45367, 4032, 3615, 1863, 16254, 8032, 3215, 12610, 3660, 37893, 995, 28820, 4724, 38251, 1829, 16095, 8717, 31371, 7435, 3660, 2423, 39184, 39, 443, 45841, 13496, 3714, 43020, 2423, 39184, 39, 443, 45841, 13496, 318, 8978, 3224, 18568, 45841, 13496, 9028, 2423, 39184, 34, 12, 39, 443, 45841, 13496, 8717, 45367, 5296, 3794, 3224, 19753, 34740, 15844, 6225, 4117, 3794, 9673, 43042, 7578, 4724, 1829, 30544, 14407, 9122, 45865, 3794, 9957, 11933, 15730, 8978, 3224, 14006, 468, 655, 295, 479, 12, 39, 443, 45841, 13496, 37495, 22653, 8608, 49628, 7649, 21984], "avg_logprob": -0.14016544643570394, "compression_ratio": 1.608910891089109, "no_speech_prob": 1.7881393432617188e-07, "words": [{"start": 4137.12, "end": 4138.12, "word": "ففي", "probability": 0.681884765625}, 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" يعني", "probability": 0.934326171875}, {"start": 4591.76, "end": 4592.02, "word": " هيك", "probability": 0.962158203125}, {"start": 4592.02, "end": 4592.28, "word": " بدنا", "probability": 0.843994140625}, {"start": 4592.28, "end": 4593.02, "word": " ناخدها", "probability": 0.8800048828125}, {"start": 4593.02, "end": 4594.12, "word": " ويكون", "probability": 0.7825520833333334}, {"start": 4594.12, "end": 4594.64, "word": " يعني", "probability": 0.74169921875}, {"start": 4594.64, "end": 4595.0, "word": " جزء", "probability": 0.9983723958333334}, {"start": 4595.0, "end": 4595.56, "word": " منه", "probability": 0.989501953125}, {"start": 4595.56, "end": 4596.56, "word": " كما", "probability": 0.964111328125}, {"start": 4596.56, "end": 4597.06, "word": " ذكرت", "probability": 0.9763997395833334}], "temperature": 1.0}, {"id": 164, "seek": 462647, "start": 4597.44, "end": 4626.48, "text": "الله العليم بفسره رتباطها بالـ Malaria أو يمكن بنقص الأكسجين أو الأكسجين ففي عندنا Beta-thalassemia وفي عندي Alpha-thalassemia، ماشي؟ في اللي لما نكون، في عندي إيش اسمه؟ لما نكون عندي Beta-thalassemia، ماشي؟ ويكون عندي Excess of Normal Alpha Chain", "tokens": [6027, 43761, 18863, 20292, 2304, 4724, 5172, 3794, 2288, 3224, 12602, 2655, 3555, 41193, 11296, 20666, 39184, 5746, 9831, 34051, 7251, 43020, 44945, 4587, 9381, 16247, 4117, 3794, 7435, 9957, 34051, 16247, 4117, 3794, 7435, 9957, 6156, 41185, 43242, 8315, 33286, 12, 392, 304, 640, 14058, 4032, 41185, 43242, 1829, 20588, 12, 392, 304, 640, 14058, 12399, 3714, 33599, 1829, 22807, 8978, 13672, 1829, 5296, 15042, 8717, 30544, 12399, 8978, 43242, 1829, 11933, 1829, 8592, 24525, 2304, 3224, 22807, 5296, 15042, 8717, 30544, 43242, 1829, 33286, 12, 392, 304, 640, 14058, 12399, 3714, 33599, 1829, 22807, 4032, 1829, 30544, 43242, 1829, 2111, 780, 295, 21277, 20588, 33252], "avg_logprob": -0.28732638088641343, "compression_ratio": 1.7819905213270142, "no_speech_prob": 1.710653305053711e-05, "words": [{"start": 4597.44, "end": 4597.96, 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{"start": 4629.46, "end": 4630.02, "word": " Microscope", "probability": 0.6854248046875}, {"start": 4630.02, "end": 4630.56, "word": " بسموه", "probability": 0.8133544921875}, {"start": 4630.56, "end": 4631.0, "word": " Heinz", "probability": 0.567626953125}, {"start": 4631.0, "end": 4631.34, "word": " Bodies", "probability": 0.6583251953125}, {"start": 4631.34, "end": 4632.32, "word": " يعني", "probability": 0.923095703125}, {"start": 4632.32, "end": 4632.86, "word": " إبارة", "probability": 0.8023681640625}, {"start": 4632.86, "end": 4633.04, "word": " عن", "probability": 0.78125}, {"start": 4633.04, "end": 4633.32, "word": " زي", "probability": 0.94287109375}, {"start": 4633.32, "end": 4633.72, "word": " هيك", "probability": 0.942138671875}, {"start": 4633.72, "end": 4635.72, "word": " نقطة", "probability": 0.7520345052083334}, {"start": 4635.72, "end": 4636.18, "word": " سودة", "probability": 0.91552734375}, {"start": 4636.18, "end": 4636.76, "word": " أكتر", "probability": 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"probability": 0.79365234375}, {"start": 4645.52, "end": 4647.2, "word": " الأكثر", "probability": 0.8968098958333334}, {"start": 4647.2, "end": 4647.58, "word": " اللي", "probability": 0.986083984375}, {"start": 4647.58, "end": 4647.82, "word": " هم", "probability": 0.921142578125}, {"start": 4647.82, "end": 4648.02, "word": " الـ", "probability": 0.947509765625}, {"start": 4648.02, "end": 4648.28, "word": " Alpha", "probability": 0.890625}, {"start": 4648.28, "end": 4648.96, "word": "-thalassemia", "probability": 0.965234375}, {"start": 4648.96, "end": 4650.0, "word": " الـ", "probability": 0.853515625}, {"start": 4650.0, "end": 4650.2, "word": " Alpha", "probability": 0.935546875}, {"start": 4650.2, "end": 4651.04, "word": "-thalassemia", "probability": 0.980859375}, {"start": 4651.04, "end": 4652.56, "word": " هي", "probability": 0.6015625}], "temperature": 1.0}, {"id": 166, "seek": 468193, "start": 4653.63, "end": 4681.93, "text": "وهنا Simple Beta-thalassemia يعني هنا زي ما انتوا شايفين فيه عندنا يعني هنا حاطين الـAffected Population الـPlax، الـIndians، الـMediterranean منطقتنا الـAsians، الجبانيين ففيه أكثر", "tokens": [2407, 3224, 8315, 21532, 33286, 12, 392, 304, 640, 14058, 37495, 22653, 34105, 30767, 1829, 19446, 16472, 2655, 14407, 13412, 995, 33911, 9957, 8978, 3224, 43242, 8315, 37495, 22653, 34105, 11331, 41193, 9957, 2423, 39184, 32, 11259, 292, 10215, 2776, 2423, 39184, 47, 25923, 12399, 2423, 39184, 21790, 2567, 12399, 2423, 39184, 42954, 1681, 24584, 9154, 9566, 38149, 8315, 2423, 39184, 10884, 2567, 12399, 25724, 3555, 7649, 1829, 9957, 6156, 41185, 3224, 5551, 4117, 49115], "avg_logprob": -0.32360195917518514, "compression_ratio": 1.4385026737967914, "no_speech_prob": 1.7881393432617188e-06, "words": [{"start": 4653.63, "end": 4654.87, "word": "وهنا", "probability": 0.8193359375}, {"start": 4654.87, "end": 4656.51, "word": " Simple", "probability": 0.031707763671875}, {"start": 4656.51, "end": 4656.89, "word": " Beta", "probability": 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"probability": 0.81982421875}, {"start": 4668.65, "end": 4669.33, "word": " الـAffected", "probability": 0.7787109375}, {"start": 4669.33, "end": 4670.11, "word": " Population", "probability": 0.6385498046875}, {"start": 4670.11, "end": 4671.87, "word": " الـPlax،", "probability": 0.5854736328125}, {"start": 4671.87, "end": 4673.55, "word": " الـIndians،", "probability": 0.86298828125}, {"start": 4673.55, "end": 4674.59, "word": " الـMediterranean", "probability": 0.819677734375}, {"start": 4674.59, "end": 4675.91, "word": " منطقتنا", "probability": 0.846923828125}, {"start": 4675.91, "end": 4677.77, "word": " الـAsians،", "probability": 0.7830078125}, {"start": 4677.77, "end": 4678.67, "word": " الجبانيين", "probability": 0.8162109375}, {"start": 4678.67, "end": 4681.39, "word": " ففيه", "probability": 0.7749837239583334}, {"start": 4681.39, "end": 4681.93, "word": " أكثر", "probability": 0.8896484375}], "temperature": 1.0}, {"id": 167, "seek": 471010, "start": 4682.44, "end": 4710.1, "text": "من نوع من الـ Mechanism حتى يعطينا Beta-thalassemia يعني الأكثر أشياء أنه طبعاً يعني الملاحظة كمان نقطة لازم واحد يكون منتبه إليها أنه ممكن عندي أنا Second cell Beta-thalassemia ممكن يصير أو Alpha-thalassemia", "tokens": [27842, 8717, 45367, 9154, 2423, 39184, 30175, 1434, 11331, 49975, 37495, 9566, 1829, 8315, 33286, 12, 392, 304, 640, 14058, 37495, 22653, 16247, 4117, 49115, 5551, 8592, 1829, 16606, 14739, 3224, 23032, 3555, 3615, 995, 14111, 37495, 22653, 9673, 15040, 5016, 19913, 3660, 9122, 2304, 7649, 8717, 47432, 3660, 5296, 31377, 2304, 36764, 24401, 7251, 30544, 9154, 2655, 3555, 3224, 11933, 20292, 11296, 14739, 3224, 3714, 43020, 18871, 16254, 41850, 5736, 2815, 33286, 12, 392, 304, 640, 14058, 3714, 43020, 7251, 9381, 13546, 34051, 20588, 12, 392, 304, 640, 14058], "avg_logprob": -0.15066964285714285, "compression_ratio": 1.5192307692307692, "no_speech_prob": 1.0728836059570312e-06, "words": [{"start": 4682.44, "end": 4682.94, "word": "من", "probability": 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"probability": 0.796875}, {"start": 4695.88, "end": 4696.38, "word": " طبعاً", "probability": 0.83857421875}, {"start": 4696.38, "end": 4696.7, "word": " يعني", "probability": 0.915771484375}, {"start": 4696.7, "end": 4697.84, "word": " الملاحظة", "probability": 0.98037109375}, {"start": 4697.84, "end": 4698.58, "word": " كمان", "probability": 0.7574869791666666}, {"start": 4698.58, "end": 4699.02, "word": " نقطة", "probability": 0.865234375}, {"start": 4699.02, "end": 4699.3, "word": " لازم", "probability": 0.9827473958333334}, {"start": 4699.3, "end": 4699.52, "word": " واحد", "probability": 0.9853515625}, {"start": 4699.52, "end": 4699.76, "word": " يكون", "probability": 0.990966796875}, {"start": 4699.76, "end": 4700.18, "word": " منتبه", "probability": 0.8489990234375}, {"start": 4700.18, "end": 4701.08, "word": " إليها", "probability": 0.7823893229166666}, {"start": 4701.08, "end": 4701.8, "word": " أنه", "probability": 0.80322265625}, {"start": 4701.8, "end": 4702.54, "word": " ممكن", "probability": 0.980712890625}, {"start": 4702.54, "end": 4703.0, "word": " عندي", "probability": 0.86328125}, {"start": 4703.0, "end": 4703.82, "word": " أنا", "probability": 0.8271484375}, {"start": 4703.82, "end": 4705.3, "word": " Second", "probability": 0.47119140625}, {"start": 4705.3, "end": 4705.82, "word": " cell", "probability": 0.54443359375}, {"start": 4705.82, "end": 4706.52, "word": " Beta", "probability": 0.8330078125}, {"start": 4706.52, "end": 4707.24, "word": "-thalassemia", "probability": 0.96630859375}, {"start": 4707.24, "end": 4708.16, "word": " ممكن", "probability": 0.95849609375}, {"start": 4708.16, "end": 4708.96, "word": " يصير", "probability": 0.7648111979166666}, {"start": 4708.96, "end": 4709.12, "word": " أو", "probability": 0.955078125}, {"start": 4709.12, "end": 4709.42, "word": " Alpha", "probability": 0.96630859375}, {"start": 4709.42, "end": 4710.1, "word": "-thalassemia", "probability": 0.98291015625}], "temperature": 1.0}, {"id": 168, "seek": 473814, "start": 4710.59, "end": 4738.15, "text": "فعشان هيك يعني بتكون إنه فيه خلالين في نفس الوقت في محالين مختلفان الـ Sickle Cell S-Hemoglobin نتيجة Beta Chain Mutation في مكان معين لإشي معين هذا بيعطينا الـ Beta-Thalassemia الـSLS-Hemoglobin والـBeta-Thalassemia في يعني", "tokens": [5172, 3615, 8592, 7649, 39896, 4117, 37495, 22653, 39894, 30544, 36145, 3224, 8978, 3224, 16490, 1211, 6027, 9957, 8978, 8717, 36178, 2423, 30543, 2655, 8978, 3714, 5016, 6027, 9957, 3714, 46456, 46538, 7649, 2423, 39184, 43471, 306, 28859, 318, 12, 39, 443, 45841, 13496, 8717, 31371, 7435, 3660, 33286, 33252, 376, 11380, 8978, 3714, 41361, 20449, 9957, 5296, 28814, 8592, 1829, 20449, 9957, 23758, 4724, 40228, 9566, 1829, 8315, 2423, 39184, 33286, 12, 2434, 304, 640, 14058, 2423, 39184, 50, 19198, 12, 39, 443, 45841, 13496, 16070, 39184, 33, 7664, 12, 2434, 304, 640, 14058, 8978, 37495, 22653], "avg_logprob": -0.2059659030702379, "compression_ratio": 1.5865384615384615, "no_speech_prob": 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محالين", "probability": 0.93408203125}, {"start": 4716.87, "end": 4717.71, "word": " مختلفان", "probability": 0.8111572265625}, {"start": 4717.71, "end": 4718.65, "word": " الـ", "probability": 0.87451171875}, {"start": 4718.65, "end": 4719.21, "word": " Sickle", "probability": 0.775146484375}, {"start": 4719.21, "end": 4719.47, "word": " Cell", "probability": 0.51611328125}, {"start": 4719.47, "end": 4719.79, "word": " S", "probability": 0.71337890625}, {"start": 4719.79, "end": 4720.57, "word": "-Hemoglobin", "probability": 0.80283203125}, {"start": 4720.57, "end": 4721.73, "word": " نتيجة", "probability": 0.9017333984375}, {"start": 4721.73, "end": 4722.93, "word": " Beta", "probability": 0.8984375}, {"start": 4722.93, "end": 4723.47, "word": " Chain", "probability": 0.65087890625}, {"start": 4723.47, "end": 4724.59, "word": " Mutation", "probability": 0.647705078125}, {"start": 4724.59, "end": 4724.83, "word": " في", "probability": 0.9580078125}, {"start": 4724.83, "end": 4725.19, "word": " مكان", "probability": 0.990966796875}, {"start": 4725.19, "end": 4725.79, "word": " معين", "probability": 0.9765625}, {"start": 4725.79, "end": 4726.47, "word": " لإشي", "probability": 0.8673095703125}, {"start": 4726.47, "end": 4726.95, "word": " معين", "probability": 0.99658203125}, {"start": 4726.95, "end": 4727.79, "word": " هذا", "probability": 0.88037109375}, {"start": 4727.79, "end": 4728.43, "word": " بيعطينا", "probability": 0.81943359375}, {"start": 4728.43, "end": 4728.87, "word": " الـ", "probability": 0.97509765625}, {"start": 4728.87, "end": 4729.05, "word": " Beta", "probability": 0.75830078125}, {"start": 4729.05, "end": 4729.75, "word": "-Thalassemia", "probability": 0.795703125}, {"start": 4729.75, "end": 4731.85, "word": " الـSLS", "probability": 0.636383056640625}, {"start": 4731.85, "end": 4732.81, "word": "-Hemoglobin", "probability": 0.89921875}, {"start": 4732.81, "end": 4734.09, "word": " والـBeta", "probability": 0.8594970703125}, {"start": 4734.09, "end": 4734.83, "word": "-Thalassemia", "probability": 0.9400390625}, {"start": 4734.83, "end": 4735.85, "word": " في", "probability": 0.9580078125}, {"start": 4735.85, "end": 4738.15, "word": " يعني", "probability": 0.8017578125}], "temperature": 1.0}, {"id": 169, "seek": 476632, "start": 4739.3, "end": 4766.32, "text": "بالنسبة للـ Beta-thalassemia بشكل عام أشياء مش deletion يعني إذا بتشوفوا شو أنواع المشاكل يعني أنا الشغلات المعقدة مديش أدخل فيها أنا مش حافظها يعني أو مش منتبئلها، شايف عليك؟ بس لاحظوا أهم نقطة إنه مش deletion اللي هي بتوقعوا في الـAlpha-thalassemia", "tokens": [3555, 6027, 1863, 35457, 3660, 24976, 39184, 33286, 12, 392, 304, 640, 14058, 4724, 8592, 28820, 6225, 10943, 5551, 8592, 1829, 16606, 37893, 1103, 302, 313, 37495, 22653, 11933, 15730, 39894, 8592, 38688, 14407, 13412, 2407, 14739, 14407, 3615, 9673, 8592, 995, 28820, 37495, 22653, 41850, 25124, 17082, 1211, 9307, 9673, 3615, 28543, 3660, 3714, 16254, 8592, 5551, 3215, 9778, 1211, 8978, 11296, 41850, 37893, 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{"start": 4752.16, "end": 4752.76, "word": " المعقدة", "probability": 0.980224609375}, {"start": 4752.76, "end": 4753.14, "word": " مديش", "probability": 0.5690104166666666}, {"start": 4753.14, "end": 4753.44, "word": " أدخل", "probability": 0.8822021484375}, {"start": 4753.44, "end": 4753.88, "word": " فيها", "probability": 0.97607421875}, {"start": 4753.88, "end": 4754.6, "word": " أنا", "probability": 0.95068359375}, {"start": 4754.6, "end": 4754.92, "word": " مش", "probability": 0.99267578125}, {"start": 4754.92, "end": 4755.54, "word": " حافظها", "probability": 0.976318359375}, {"start": 4755.54, "end": 4755.8, "word": " يعني", "probability": 0.79296875}, {"start": 4755.8, "end": 4755.96, "word": " أو", "probability": 0.9375}, {"start": 4755.96, "end": 4756.16, "word": " مش", "probability": 0.99365234375}, {"start": 4756.16, "end": 4757.72, "word": " منتبئلها،", "probability": 0.7434430803571429}, {"start": 4757.72, "end": 4757.96, "word": " شايف", "probability": 0.92822265625}, {"start": 4757.96, "end": 4758.5, "word": " عليك؟", "probability": 0.714599609375}, {"start": 4758.5, "end": 4758.78, "word": " بس", "probability": 0.941162109375}, {"start": 4758.78, "end": 4759.5, "word": " لاحظوا", "probability": 0.9818115234375}, {"start": 4759.5, "end": 4759.9, "word": " أهم", "probability": 0.984619140625}, {"start": 4759.9, "end": 4760.56, "word": " نقطة", "probability": 0.9811197916666666}, {"start": 4760.56, "end": 4761.36, "word": " إنه", "probability": 0.714111328125}, {"start": 4761.36, "end": 4761.86, "word": " مش", "probability": 0.97314453125}, {"start": 4761.86, "end": 4763.5, "word": " deletion", "probability": 0.7882486979166666}, {"start": 4763.5, "end": 4763.86, "word": " اللي", "probability": 0.95556640625}, {"start": 4763.86, "end": 4764.08, "word": " هي", "probability": 0.7294921875}, {"start": 4764.08, "end": 4765.14, "word": " بتوقعوا", "probability": 0.7955322265625}, {"start": 4765.14, "end": 4765.32, "word": " في", "probability": 0.292236328125}, {"start": 4765.32, "end": 4765.68, "word": " الـAlpha", "probability": 0.922119140625}, {"start": 4765.68, "end": 4766.32, "word": "-thalassemia", "probability": 0.945703125}], "temperature": 1.0}, {"id": 170, "seek": 479597, "start": 4767.68, "end": 4795.98, "text": "الشغل التاني كنوع Specific للـ Defect في كل نوع من الـ Beta-thalassemia هذا بيحطوا Beta-thalassemia Plus أو Beta Zero Beta Zero بيكون more يعني Severe in the manifestation بيكون درجة الأنيميا، درجة الخلل شديد كثير", "tokens": [6027, 8592, 17082, 1211, 16712, 7649, 1829, 9122, 1863, 45367, 20484, 1089, 24976, 39184, 1346, 1836, 8978, 28242, 8717, 45367, 9154, 2423, 39184, 33286, 12, 392, 304, 640, 14058, 23758, 4724, 1829, 5016, 9566, 14407, 33286, 12, 392, 304, 640, 14058, 7721, 34051, 33286, 17182, 33286, 17182, 4724, 1829, 30544, 544, 37495, 22653, 1100, 5887, 294, 264, 29550, 4724, 1829, 30544, 11778, 47341, 3660, 16247, 1863, 32640, 25528, 12399, 11778, 47341, 3660, 33962, 1211, 1211, 13412, 16254, 3215, 9122, 12984, 13546], "avg_logprob": -0.1987423755046798, "compression_ratio": 1.4752475247524752, "no_speech_prob": 1.7881393432617188e-07, "words": [{"start": 4767.68, "end": 4768.16, "word": "الشغل", "probability": 0.9195556640625}, {"start": 4768.16, "end": 4768.76, "word": " التاني", "probability": 0.9236653645833334}, {"start": 4768.76, "end": 4771.16, "word": " كنوع", "probability": 0.9397786458333334}, {"start": 4771.16, "end": 4772.26, "word": " Specific", "probability": 0.5924072265625}, {"start": 4772.26, "end": 4773.32, "word": " للـ", "probability": 0.691162109375}, {"start": 4773.32, "end": 4775.24, "word": " Defect", "probability": 0.61334228515625}, {"start": 4775.24, "end": 4775.84, "word": " في", "probability": 0.411865234375}, {"start": 4775.84, "end": 4776.08, "word": " كل", "probability": 0.9755859375}, {"start": 4776.08, "end": 4776.32, "word": " نوع", "probability": 0.991455078125}, {"start": 4776.32, "end": 4776.56, "word": " من", "probability": 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بـ low sea level أكتر ممكن أنه يكون يحب يروح هناك لأنه بيشوف حاله أحسن بيصيبوش نفس المرض في أي ناحية بالنسبة للـ Alpha Thalassemia", "tokens": [3555, 9640, 3215, 37495, 22653, 4724, 1829, 5016, 3555, 7251, 1863, 11622, 1211, 15844, 2423, 39184, 2423, 39184, 2423, 39184, 15844, 2423, 39184, 4158, 1496, 6225, 8592, 7649, 8717, 35457, 3660, 2423, 39184, 16489, 8647, 5551, 4117, 2655, 2288, 4032, 28814, 15730, 8717, 35457, 3660, 2423, 39184, 16489, 8647, 5551, 4117, 2655, 2288, 8978, 16247, 17082, 2407, 9640, 4032, 41185, 3714, 41361, 4724, 39184, 2295, 4158, 1496, 5551, 4117, 2655, 2288, 3714, 43020, 14739, 3224, 7251, 30544, 7251, 5016, 3555, 7251, 32887, 5016, 34105, 4117, 5296, 33456, 3224, 4724, 1829, 8592, 38688, 11331, 6027, 3224, 5551, 5016, 3794, 1863, 4724, 1829, 9381, 1829, 3555, 2407, 8592, 8717, 36178, 9673, 43042, 8978, 36632, 8717, 39319, 10632, 20666, 1863, 35457, 3660, 24976, 39184, 20588, 334, 304, 640, 14058], "avg_logprob": -0.16756889411783593, "compression_ratio": 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{"start": 5069.36, "end": 5069.72, "word": " يروح", "probability": 0.9915364583333334}, {"start": 5069.72, "end": 5070.38, "word": " هناك", "probability": 0.97412109375}, {"start": 5070.38, "end": 5071.06, "word": " لأنه", "probability": 0.9557291666666666}, {"start": 5071.06, "end": 5071.38, "word": " بيشوف", "probability": 0.9552001953125}, {"start": 5071.38, "end": 5071.7, "word": " حاله", "probability": 0.98828125}, {"start": 5071.7, "end": 5072.16, "word": " أحسن", "probability": 0.9964599609375}, {"start": 5072.16, "end": 5072.96, "word": " بيصيبوش", "probability": 0.8350655691964286}, {"start": 5072.96, "end": 5073.18, "word": " نفس", "probability": 0.994873046875}, {"start": 5073.18, "end": 5073.64, "word": " المرض", "probability": 0.990966796875}, {"start": 5073.64, "end": 5074.58, "word": " في", "probability": 0.400634765625}, {"start": 5074.58, "end": 5074.78, "word": " أي", "probability": 0.701171875}, {"start": 5074.78, "end": 5075.32, "word": " ناحية", "probability": 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{"start": 5101.85, "end": 5102.11, "word": " Alpha", "probability": 0.73681640625}, {"start": 5102.11, "end": 5102.59, "word": " 2", "probability": 0.978515625}, {"start": 5102.59, "end": 5104.57, "word": " عندي", "probability": 0.923583984375}, {"start": 5104.57, "end": 5104.93, "word": " أربعة", "probability": 0.9666341145833334}, {"start": 5104.93, "end": 5105.65, "word": " copies", "probability": 0.99365234375}, {"start": 5105.65, "end": 5106.75, "word": " والأمر", "probability": 0.773193359375}, {"start": 5106.75, "end": 5107.29, "word": " بكون", "probability": 0.79443359375}, {"start": 5107.29, "end": 5108.05, "word": " deletion", "probability": 0.7088216145833334}], "temperature": 1.0}, {"id": 182, "seek": 513643, "start": 5108.62, "end": 5136.44, "text": "فممكن إنسان الأسان الطبيعي عنده الأربع إذا واحد راح، بكون إش خفيف وما بسويش إشي، بعملش مرض فمن يروح اتنين، بنسميه Alpha Thalassemia Carrier إذا ثلاثة راحل وبظل one copy، بكون يعني Persevered", "tokens": [5172, 2304, 43020, 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CDC اللي بتطلع من الجهاز فيها معلومات كثيرة الـ Hemoglobin و بعدين الـ MCH اللي هو الـ Main Carboxylic Volume MCD و MCH و MCHC فهي فيه مؤشرات", "tokens": [40228, 22653, 2423, 39184, 376, 5462, 34, 11933, 15730, 14739, 2655, 39894, 8592, 38688, 1829, 2423, 39184, 17133, 11933, 15730, 13412, 5172, 2655, 1829, 8717, 31371, 7435, 3660, 2423, 39184, 17133, 13672, 1829, 39894, 9566, 1211, 3615, 9154, 25724, 3224, 31377, 8978, 11296, 20449, 1211, 20498, 9307, 9122, 12984, 48923, 2423, 39184, 18568, 45841, 13496, 4032, 39182, 9957, 2423, 39184, 376, 5462, 13672, 1829, 31439, 2423, 39184, 12383, 2741, 4995, 88, 1050, 38448, 376, 16508, 4032, 376, 5462, 4032, 376, 5462, 34, 6156, 3224, 1829, 8978, 3224, 3714, 33604, 46309, 9307], "avg_logprob": -0.20261548718680505, "compression_ratio": 1.5729166666666667, "no_speech_prob": 2.384185791015625e-07, "words": [{"start": 5762.84, "end": 5763.42, "word": "يعني", "probability": 0.857666015625}, {"start": 5763.42, "end": 5763.82, "word": " الـ", 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5980.27, "end": 5980.53, "word": " العافية", "probability": 0.8859049479166666}, {"start": 5980.53, "end": 5980.63, "word": " يا", "probability": 0.93017578125}, {"start": 5980.63, "end": 5983.29, "word": " دكتور،", "probability": 0.88466796875}, {"start": 5983.29, "end": 5983.51, "word": " الله", "probability": 0.42724609375}, {"start": 5983.51, "end": 5983.99, "word": " يسهل", "probability": 0.9078369140625}, {"start": 5983.99, "end": 5984.17, "word": " يا", "probability": 0.5078125}, {"start": 5984.17, "end": 5984.93, "word": " أمك،", "probability": 0.74273681640625}, {"start": 5984.93, "end": 5985.19, "word": " يالا", "probability": 0.56396484375}, {"start": 5985.19, "end": 5985.53, "word": " السلام", "probability": 0.9443359375}, {"start": 5985.53, "end": 5985.83, "word": " عليك", "probability": 0.8818359375}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 5987.776125, "duration_after_vad": 5880.630625000027}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/1-iWE_Sbnvw_raw.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/1-iWE_Sbnvw_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..fd4e214b3f8aebb47dff6d74305810cc150a5593
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/1-iWE_Sbnvw_raw.srt
@@ -0,0 +1,3996 @@
+1
+00:00:03,500 --> 00:00:10,420
+أيه؟ أين راحت؟ اسمع ليني عشان أعمل share screen
+
+2
+00:00:10,420 --> 00:00:16,820
+share screen طيب
+
+3
+00:00:16,820 --> 00:00:25,200
+بسم الله الرحمن الرحيم بالنسبة
+
+4
+00:00:25,200 --> 00:00:34,630
+لـ إن شاء الله محاضرة اليومراح نتكلم عن يعني
+
+5
+00:00:34,630 --> 00:00:43,310
+تطبيقات في جانب مهم من الأمراض الوراثية والوراثة
+
+6
+00:00:43,310 --> 00:00:50,390
+ومبادئها على الجانب المهم وهو الدم، الـHemoglobin
+
+7
+00:00:50,390 --> 00:00:53,630
+فبالنسبة
+
+8
+00:00:53,630 --> 00:00:59,920
+لكتابكم، احنا بشكل عامما كنت حابب أنه كمبادئ للـ
+
+9
+00:00:59,920 --> 00:01:04,320
+Genetics أنه ندخل في الـ Specific Diseases والـ
+
+10
+00:01:04,320 --> 00:01:09,440
+Specific Conditions بس أحيانًا تضطر عشان تفهم
+
+11
+00:01:09,440 --> 00:01:15,000
+الموضوع تمامًا من ناحية الوراطب في جانب معين ويكون
+
+12
+00:01:15,000 --> 00:01:21,020
+مهم إنك تدرس مثال عليها وتفهم كيف احنا الآن في
+
+13
+00:01:21,020 --> 00:01:28,040
+العصر الحاليوبنربط الجينات
+
+14
+00:01:28,040 --> 00:01:34,480
+بتفاصيلها الدقيقة بالحالات والأمراض ونشوف كيف
+
+15
+00:01:34,480 --> 00:01:41,520
+تنتقل من جين على مستوى الـ DNA لمستوى إنه يكون مرض
+
+16
+00:01:41,520 --> 00:01:46,680
+عند الإنسان بس قبل ما ندخل في المحاضرة وندخل في
+
+17
+00:01:46,680 --> 00:01:50,980
+تفاصيل
+
+18
+00:01:50,980 --> 00:01:58,410
+الأموركنت بدي أبدأ بسؤال اللي اعتقدتمه يعني
+
+19
+00:01:58,410 --> 00:02:06,950
+افترضنا إنه احنا صوّينا الـ
+
+20
+00:02:06,950 --> 00:02:15,630
+AVO type للـ Badge تبعتكم حوالي 151 وشوفنا
+
+21
+00:02:15,630 --> 00:02:20,030
+الـ frequency of the alleles أسف الـ frequency of
+
+22
+00:02:20,030 --> 00:02:24,980
+the typesحطيت أنا النسب هذه صراحة السؤال غلط
+
+23
+00:02:24,980 --> 00:02:31,000
+ومنحلش من ناحية إنه أنا اللي حطيته نسب هيك من رأسي
+
+24
+00:02:31,000 --> 00:02:36,140
+جمعت ان يكونوا 100 وحطيتها هيك يعني وهذا كان سؤال
+
+25
+00:02:36,140 --> 00:02:46,260
+خاطر يعني مش هيك بس الحل الحل كان إن الواحد يمسك
+
+26
+00:02:46,260 --> 00:02:52,260
+في الأشياء القوية الواضحةاللي يعني إلها معلومات
+
+27
+00:02:52,260 --> 00:03:00,740
+مفيدة وفيه صراحة رقمين يعني صحيحه بالنسبة
+
+28
+00:03:00,740 --> 00:03:09,680
+كأرقام نسب حتى تهيكة بذكر فيه معادلتين المعادل
+
+29
+00:03:09,680 --> 00:03:16,260
+الأولى إنه إذا اختردنا عنا Two alleles إذا كانوا
+
+30
+00:03:16,260 --> 00:03:23,940
+في one certain locusإذا المعادلتين طبعته إنه الـP
+
+31
+00:03:23,940 --> 00:03:30,280
+زاد الـQ بساوي 1 والـP تربيع زاد 2PQ زاد Q تربيع
+
+32
+00:03:30,280 --> 00:03:33,600
+بساوي 1 دولة دايماً الرقمين اللي بدنا ندعو
+
+33
+00:03:33,600 --> 00:03:37,720
+معادلتين المهمات عشان واحد في الواحد يدبر حاله
+
+34
+00:03:37,720 --> 00:03:44,480
+فإذا افترضنا إن الـO type 30% الـO type هو
+
+35
+00:03:44,480 --> 00:03:51,120
+الـRecessive وبالتاليحتى يظهر لازم يكون homozygous
+
+36
+00:03:51,120 --> 00:03:57,180
+لازم يكون pure لازم يكون تنتم من الـO فإذا الـQ
+
+37
+00:03:57,180 --> 00:04:01,680
+تربيع بساوي يعني هو أنا بدأ ناخد الـQ تربيع لأن
+
+38
+00:04:01,680 --> 00:04:11,140
+هذه نسبة الـO فبدا تكون 0.3 فالـQ بدا تكون 0.548
+
+39
+00:04:11,140 --> 00:04:18,420
+يعني 55% تقريبًا حتى كجين على مستوى القليلتحيث إنه
+
+40
+00:04:18,420 --> 00:04:25,080
+يكون 30% recessive لهذا الدرجة واضح وبالتالي احنا
+
+41
+00:04:25,080 --> 00:04:33,680
+أنا كان يعني صحيح حصلت اثنين بس يعني الـA والـB
+
+42
+00:04:33,680 --> 00:04:41,480
+المرة هذه يعني مش بس one، one القليل غير الـO
+
+43
+00:04:41,480 --> 00:04:45,940
+الـdominant يعني عندى اثنين dominant الـA والـB
+
+44
+00:04:47,160 --> 00:04:52,120
+وكنت أنا بدي أقول إن الـFrequency تبعتهم اللي هي
+
+45
+00:04:52,120 --> 00:05:01,520
+الـA زي الـB بساوة البقية لأنه راح يكونوا عبارة عن
+
+46
+00:05:01,520 --> 00:05:07,760
+اللي أخدنا معادلة الـB زي الـQ بساوة واحد والـQ
+
+47
+00:05:07,760 --> 00:05:12,920
+طلعت هالقدة، هاي الـB اللي هي الـFrequency تبعت
+
+48
+00:05:12,920 --> 00:05:21,160
+الـA والـBبساوي اللي هو الـ P اللي هي بقيت الواحد
+
+49
+00:05:21,160 --> 00:05:29,260
+فهيكون إن الـ X والـ Y بساوية 0.452 فإن هذه
+
+50
+00:05:29,260 --> 00:05:37,540
+معادلتين ماشي، والنقطة المهمة من النسب اللي احنا
+
+51
+00:05:37,540 --> 00:05:43,620
+حصلنا عليها اللي هو الـ AB الـ AB is codominant
+
+52
+00:05:44,380 --> 00:05:51,280
+يعني الـ «A» ظاهر والـ «B» ظاهر فحتى نشوف نسبة الـ
+
+53
+00:05:51,280 --> 00:05:57,720
+Frequency هذه في الـ Population بدا تكون «X» ضارب
+
+54
+00:05:57,720 --> 00:06:04,120
+«Y» ساوي 26% فصراحة لما جيتنا نفعلنا معادلتين
+
+55
+00:06:04,120 --> 00:06:10,740
+بمجهولين ونقدر بالرياضيات نحلها، هيك الأصل وأنا
+
+56
+00:06:10,740 --> 00:06:15,930
+فكرت أن هيك تقدر بسهولةالواحد يطلّع النسب كلهم
+
+57
+00:06:15,930 --> 00:06:22,090
+ويطبّقها الصراحة طلعت تنحلّش بسبب إن الأرقام مش
+
+58
+00:06:22,090 --> 00:06:27,730
+مظبوطة يعني مافيش أرقام بتحقق هذه النسب بهذه
+
+59
+00:06:27,730 --> 00:06:36,530
+الطريقة بشكل سليم فبعتذر عن المثال كان شوية مستعجل
+
+60
+00:06:36,530 --> 00:06:44,710
+وكان يعني بيكفي الواحد من هدولة النسبتيناللي هو
+
+61
+00:06:44,710 --> 00:06:51,070
+يعني الـ O بشكل واضح والـ A وD بشكل واضح الواحد
+
+62
+00:06:51,070 --> 00:06:58,250
+كان ممكن يطلع كل الأرقام والأصل أنه كان أنا طلعت
+
+63
+00:06:58,250 --> 00:07:03,550
+الإجابات وحطيت شو هي النسب وأعطيتكم إياها عشان
+
+64
+00:07:03,550 --> 00:07:10,770
+تحلوهم بس أتوقع يعني كـ Exercise الواحد بده يشوف
+
+65
+00:07:10,770 --> 00:07:18,830
+لما يقرأ والواحدطلابكم، أحد زملائكم ذكر إنه هو
+
+66
+00:07:18,830 --> 00:07:25,130
+اتطلع على study وشاف فيها النسب وكيف كانت طلعوهم
+
+67
+00:07:25,130 --> 00:07:31,290
+وكذا، بس بتكون من هذا المبدأ، في أسئلة؟ أو في أحد
+
+68
+00:07:31,290 --> 00:07:37,390
+عنده أسئلة حتى عن الامتحان أو عن دكتور
+
+69
+00:07:37,390 --> 00:07:44,540
+أحمد، أنا عادة بالنسبة للامتحاناتبحط جزء من سواء
+
+70
+00:07:44,540 --> 00:07:50,020
+المحاضرة أو إذا كان الناس بيسموه الـ OSCE و الـ
+
+71
+00:07:50,020 --> 00:07:56,360
+Mini OSCE وكذا بحط إنه نجاوب الأسئلة يعني ماعندي
+
+72
+00:07:56,360 --> 00:08:04,100
+مشكلة إنه جزء من المحاضرة الجاية بحط الأسئلة و
+
+73
+00:08:04,100 --> 00:08:09,660
+نقرأ شو الإجابات كانت حتى الواحد ينتبهفي أسئلة قبل
+
+74
+00:08:09,660 --> 00:08:22,060
+ما نبدأ يا شباب ويا دكتورات الأسئلة
+
+75
+00:08:22,060 --> 00:08:27,020
+المعتادة يعني بيسألوا قاعدين عن النصفي في أي شبات
+
+76
+00:08:27,020 --> 00:08:31,240
+اللي راح يكون أما الأمور الامتحانات وترتيبها ما
+
+77
+00:08:31,240 --> 00:08:34,160
+بدناها هنا سبب نسأل الـ Genetics حد عنده سؤال في
+
+78
+00:08:34,160 --> 00:08:34,820
+الـ Genetics
+
+79
+00:08:48,290 --> 00:08:57,910
+أذا خلّينا نبدأ بمحاضرة اليوم اللي هي يعني بدأ
+
+80
+00:08:57,910 --> 00:09:01,490
+ندخل الـ Molecular Basis of Genetic Diseases
+
+81
+00:09:01,490 --> 00:09:08,470
+الفكرة
+
+82
+00:09:08,470 --> 00:09:15,270
+هنا إنه إحناالإنسان إذا باعتبر إن الله سبحانه
+
+83
+00:09:15,270 --> 00:09:23,450
+وتعالى خلقه في أحسن تقويم بطريقة مصبوطة بأحسن
+
+84
+00:09:23,450 --> 00:09:30,090
+تقويم لما تصير mutation كيف الـ mutation هذه تتحول
+
+85
+00:09:30,090 --> 00:09:36,450
+إلى إنه الـ mutation
+
+86
+00:09:36,450 --> 00:09:40,630
+هذه أو الطقرة هذه في الـ DNA تتحول إنها تكون مرضى
+
+87
+00:09:41,040 --> 00:09:45,780
+تكون Disease فالمبدأ
+
+88
+00:09:45,780 --> 00:09:55,000
+الأساسي وهو الـ Graph أو الـ Figure فيه
+
+89
+00:09:55,000 --> 00:10:02,180
+يعني مبادئ أساسية ورح نخدها بطريقة ثانية اللي هي
+
+90
+00:10:02,180 --> 00:10:10,180
+Table بهذا الشكل على طريقة تأثير
+
+91
+00:10:10,670 --> 00:10:16,990
+الـ «طفرة» أو الـ mutation على إنها اتسبب المرض
+
+92
+00:10:16,990 --> 00:10:24,470
+النقطة الأولى، بدل واحد يتذكر إنه «الطفرة» هذه قد
+
+93
+00:10:24,470 --> 00:10:30,910
+تكون باحتمالين إنها تعمل mutation in the coding
+
+94
+00:10:30,910 --> 00:10:35,590
+region يعني في المنطقة المسئولة تماماً عن البروتين
+
+95
+00:10:35,590 --> 00:10:45,340
+اللي ناتج عن الجين هذاأو إنها تفرق في جوانب أخرى
+
+96
+00:10:45,340 --> 00:10:50,700
+اللي هي التحكم في إنتاج البروتين بحيث إنه بالأخير
+
+97
+00:10:50,700 --> 00:10:56,380
+الـ protein structure is normal بس الـ gene
+
+98
+00:10:56,380 --> 00:11:05,850
+regulationالـ Dosage تبع البروتين اللي
+
+99
+00:11:05,850 --> 00:11:11,590
+قد يكون نتيجة يعني بتذكر الواحد إن الـSnips هدولة
+
+100
+00:11:11,590 --> 00:11:15,890
+Single Nucleotide Polymorphism اللي هم Very Common
+
+101
+00:11:15,890 --> 00:11:20,870
+اللي هي تقريبًا في أي إنسان من خمس إلى عشر ملايين
+
+102
+00:11:20,870 --> 00:11:27,720
+Snips موجودة عنده كثير منهم ما بيغيروا البروتينما
+
+103
+00:11:27,720 --> 00:11:31,420
+بيغيروه، يعني بيكون بالأخير هاي الـSnip إحنا
+
+104
+00:11:31,420 --> 00:11:35,900
+نستفيد منها في التشخيص أحيانًا في الـMarkers وكده
+
+105
+00:11:35,900 --> 00:11:42,520
+بس هي حقيقةً لا تؤثر في الوظيفة ففي ميوتاشن، بدنا
+
+106
+00:11:42,520 --> 00:11:48,740
+نفرقكم، إشي تكون في الـCoding Region بالتالي
+
+107
+00:11:48,740 --> 00:11:56,360
+بيعطينا Abnormal Proteins أو في الـRegulationتبع
+
+108
+00:11:56,360 --> 00:12:00,640
+الـ Gene Expression في حياته إنه بيصير عندي ولو إن
+
+109
+00:12:00,640 --> 00:12:05,860
+الـ Protein Structure is normal بس الكمية أو الـ
+
+110
+00:12:05,860 --> 00:12:11,020
+Function من ناحية أخرى بتكون Abnormal النقطة
+
+111
+00:12:11,020 --> 00:12:19,080
+الثانية إنه في أحيانًا الـGenetic Diseases اللي
+
+112
+00:12:19,080 --> 00:12:26,620
+بتأثر بالمحصلة على الـRNA Level يعني هناعلى الـ
+
+113
+00:12:26,620 --> 00:12:31,600
+Mutations Disturbing الـ RNA Stability يعني هاي
+
+114
+00:12:31,600 --> 00:12:37,100
+برضه جانب آخر مش دايماً أي Disease Genetic Disease
+
+115
+00:12:37,100 --> 00:12:44,740
+بلاقي إنه في الأخير فيه يعني عندي الـ DNA هو اللي
+
+116
+00:12:44,740 --> 00:12:48,760
+فيه المشكلة أحياناً بتصير أمراض نتيجة إن الـ RNA
+
+117
+00:12:48,760 --> 00:12:54,500
+بعد ما يصير Transcription بيصير عليه مشاكل ف
+
+118
+00:12:56,960 --> 00:13:05,120
+الحالات الأولى لما نكون الـ mutation أو الطفرة في
+
+119
+00:13:05,120 --> 00:13:11,240
+الـ coding DNA اللي هي مباجرة مسئولة عن الـ
+
+120
+00:13:11,240 --> 00:13:16,840
+protein abnormality اللي هي هنا فلما نكون عندنا
+
+121
+00:13:16,840 --> 00:13:22,340
+protein abnormality ممكنإذا عندها Unstable
+
+122
+00:13:22,340 --> 00:13:31,780
+Decreased Amount وهنا عبارة عن Hemoglobin نوعية
+
+123
+00:13:31,780 --> 00:13:35,580
+خاصة اللي هو Hammersmith اللي هو اسم المستشفى
+
+124
+00:13:35,580 --> 00:13:41,020
+ببريطانيا اللي اكتشفوا الـ Hemoglobin هذا عنده
+
+125
+00:13:41,020 --> 00:13:48,760
+فسموه بهذا الاسم نوعي معين ممكن أنه يكون عندي اللي
+
+126
+00:13:48,760 --> 00:13:55,570
+هي أنهالـ Loss of the protein function إنه أنا
+
+127
+00:13:55,570 --> 00:14:01,810
+أخبط للبروتين لأنه abnormal صار في عندي Loss of
+
+128
+00:14:01,810 --> 00:14:06,290
+the function أو إنه gain of functions أحياناً
+
+129
+00:14:06,290 --> 00:14:12,390
+بيكون أقوى من اللازم زي راح نأخد مثال على اللي هي
+
+130
+00:14:12,390 --> 00:14:17,690
+higher مثلاً
+
+131
+00:14:17,690 --> 00:14:24,200
+Oxygen affinity للهيمoglobinفزادت وظيفة، يعني ماسك
+
+132
+00:14:24,200 --> 00:14:27,980
+الـ Hemoglobin بالأكسجين كتير فصار الـ Endogenous
+
+133
+00:14:27,980 --> 00:14:34,940
+Function أو Noble Property يعني صفة مختلفة وجديدة
+
+134
+00:14:34,940 --> 00:14:40,600
+تماماً نتيجة الخلل اللي صار زي في حالات الـ Sickle
+
+135
+00:14:40,600 --> 00:14:44,280
+Cell Anemia الـ Sickle Cell Hemoglobin اللي هو
+
+136
+00:14:44,280 --> 00:14:48,780
+بيسموه Hemoglobin S اللي هو بيصير إنهلمّا ينقص
+
+137
+00:14:48,780 --> 00:14:53,760
+الأكسجين يصير الـ Clumping of the Hemoglobin
+
+138
+00:14:53,760 --> 00:15:01,040
+موليكيول يصير عندي Cycling ويصير عندي Disease فهذه
+
+139
+00:15:01,040 --> 00:15:05,700
+هي ميكانيزم للمرض لما يكون عندي protein abnormal
+
+140
+00:15:05,700 --> 00:15:13,640
+يعني المرض نتيجة سواء زيادة الـ Function قلة الـ
+
+141
+00:15:13,640 --> 00:15:20,390
+Function قلة البروتينأو وظيفة جديدة تماماً، ملاحظة
+
+142
+00:15:20,390 --> 00:15:28,430
+جديدة تماماً فالـ Protein abnormality بيكون
+
+143
+00:15:28,430 --> 00:15:33,110
+through multiple mechanisms leading to the disease
+
+144
+00:15:33,110 --> 00:15:38,910
+ممكن الـ Protein structure is normal بس الـ
+
+145
+00:15:38,910 --> 00:15:43,610
+mutation في الـ control فبتأثر على الـ dosage أو
+
+146
+00:15:43,610 --> 00:15:49,930
+level of the expressionفـ Decreased amount زي
+
+147
+00:15:49,930 --> 00:15:56,690
+التلاثيميا راح ناخد أنواع التلاثيميا وشو المنوعة
+
+148
+00:15:56,690 --> 00:16:01,170
+بس كمان يعني هذه الـ Abnormal Structure أو الـ
+
+149
+00:16:01,170 --> 00:16:04,810
+Function هو أنا Abnormal Function حتى في الـ Tumor
+
+150
+00:16:04,810 --> 00:16:08,730
+Suppressor Mutations بتؤدي للـ Loss of Function
+
+151
+00:16:08,730 --> 00:16:16,610
+بتلاقيها بعدين في عنديفي عندي diseases نتيجة
+
+152
+00:16:16,610 --> 00:16:21,290
+الغناط بمعنى الـ Cancer الـ Increased amount بيصير
+
+153
+00:16:21,290 --> 00:16:28,370
+لنا gain of function مثلًا Trisomy أي عبارة عن لما
+
+154
+00:16:28,370 --> 00:16:37,210
+نكون زي ما خدنا مثلًا Trisomy 21 وبالتالييعني
+
+155
+00:16:37,210 --> 00:16:42,690
+الأصل أنه فيه زيادة في level of the proteins لأنه
+
+156
+00:16:42,690 --> 00:16:46,370
+الجينات صارت أكتر فيه مرض اسمه «Charcot-Marie
+
+157
+00:16:46,370 --> 00:16:53,430
+-Tooth Type-A» تبارك عن مرض عصبي بيصير فيه ضعف
+
+158
+00:16:53,430 --> 00:17:03,610
+العضلات وضعف العصاب وهنا بتكون يعني فيه نوع من الـ
+
+159
+00:17:04,720 --> 00:17:09,700
+«Controller» جين معين بيصير عندي زيادة وبقى ضمن
+
+160
+00:17:09,700 --> 00:17:13,940
+إنه يتظامن فيه أنواع X-linked وفيه تظامن dominant
+
+161
+00:17:13,940 --> 00:17:23,700
+وفيه له أنواع مش مهمة كتير وفي عندنا اللي هي topic
+
+162
+00:17:23,700 --> 00:17:28,840
+or heterochronic expression راح نعطي أمثلة عنها
+
+163
+00:17:28,840 --> 00:17:34,970
+ويعني اللي هي إنهالأصل إنه فيه جينات بتشتغل وفيه
+
+164
+00:17:34,970 --> 00:17:39,970
+جينات ساكتة في كل مرحلة من حياة الإنسان بتلاقي
+
+165
+00:17:39,970 --> 00:17:44,430
+مفروض جينات معينة هي بتشتغل وبعدين الأشياء التانية
+
+166
+00:17:44,430 --> 00:17:50,850
+بتصير اتوقف فإذا صار إنه الشغل والتوقيف مش مظبوط،
+
+167
+00:17:50,850 --> 00:17:54,430
+ماشي تصير عندي inappropriate expression and wrong
+
+168
+00:17:54,430 --> 00:17:59,690
+time or place كانت سبب للـDisease أنا بعتبر يعني
+
+169
+00:17:59,690 --> 00:18:08,410
+كمبادئلقضية إيش اللي بيخرب وإيش كيف من الانتقال من
+
+170
+00:18:08,410 --> 00:18:11,730
+الـMutation لـDisease وليش بيكون الـDisease بهذا
+
+171
+00:18:11,730 --> 00:18:19,610
+الشكل بدا تكون يعني نتيجة خلل بأحد هذه الطرق بأحد
+
+172
+00:18:19,610 --> 00:18:28,150
+هذه الـMechanism لما ناخد يعني الـA باعتبروها الـ8
+
+173
+00:18:28,150 --> 00:18:32,860
+Stepsبالنسبة للميوتاشيون التي يمكنها تغيير نشاط
+
+174
+00:18:32,860 --> 00:18:40,540
+البروتين العادل يعني هنا بيحاولوا يعطوكم كل أنواع
+
+175
+00:18:40,540 --> 00:18:50,060
+الخلل اللي بتأدي من المرض أو الـ mutation بحيث أنه
+
+176
+00:18:50,060 --> 00:18:58,380
+يعني كانت بنتج عن الـ mutation لتوصل إلى تسبب
+
+177
+00:18:58,380 --> 00:19:07,450
+المرضالآن ممكن المشكلة تكون «at the stage» أو «at
+
+178
+00:19:07,450 --> 00:19:14,890
+the transcription» بطرحكم مثلًا الفلسينيا يعني
+
+179
+00:19:14,890 --> 00:19:22,310
+إحنا من البداية إذا في أسئلة وقفوني ما تخلونيش
+
+180
+00:19:22,310 --> 00:19:28,030
+أكمل إذا في إيش مش واضحأنا من الأهم أشياء اللي بحب
+
+181
+00:19:28,030 --> 00:19:36,650
+أركز عليها قضية المبادئ يعني مثلاً لما نقول سرطان
+
+182
+00:19:36,650 --> 00:19:44,370
+دم خلايا الدم وتكون في العقد الليمفاوي فقط بنسميه
+
+183
+00:19:44,370 --> 00:19:52,150
+lymphoma إذا بتكون وصل جوا خلايا أو وصل جوا الدم
+
+184
+00:19:52,760 --> 00:19:57,440
+يعني صارت الخلايا السرطانية جوا الدم نفسه فبنسميه
+
+185
+00:19:57,440 --> 00:20:00,980
+Leukemia فالـ Leukemia والـ Lymphoma هم نفس
+
+186
+00:20:00,980 --> 00:20:09,600
+السرطان نفس الخلايا وأحياناً بتلاقوا أنه الأمور
+
+187
+00:20:09,600 --> 00:20:13,980
+مشتبهة فهي أنا بهمني يعني من اللي بركز للدكاترة
+
+188
+00:20:13,980 --> 00:20:19,380
+والطلاب الطب أنه الواحد يفرق بين الـ Leukemia والـ
+
+189
+00:20:19,380 --> 00:20:23,810
+Lymphoma هذه المبدأ يعني فاحناالـ
+
+190
+00:20:23,810 --> 00:20:30,230
+hemoglobinopathies الـ diseases كلها تمجموعة تنقسم
+
+191
+00:20:30,230 --> 00:20:35,690
+لثلاث أنواع أو حطوها ثلاث أنواع هنا في إيش اسمه
+
+192
+00:20:35,690 --> 00:20:42,350
+ثلاثينية يعني إحنا بنقسم الـ hemoglobinopathies زي
+
+193
+00:20:42,350 --> 00:20:46,170
+ما بيقولوا quantitative و qualitative في مشكلة في
+
+194
+00:20:46,170 --> 00:20:55,770
+الكمية وفي مشكلة في الوظيفة والنوعية إذاالكمية تبع
+
+195
+00:20:55,770 --> 00:20:59,730
+الـ Hemoglobin نحن نسميه تلاثينيا فتلاثينيا هي
+
+196
+00:20:59,730 --> 00:21:03,230
+quantitative Hemoglobin Hepatocyte يمكن أن يكون
+
+197
+00:21:03,230 --> 00:21:09,570
+فيه مشكلة في عدد أو كمية الـ Hemoglobin ويكون فيه
+
+198
+00:21:09,570 --> 00:21:16,390
+مشكلة بالنسبة لها فالـ High نحن نسميها تلاثينيا
+
+199
+00:21:16,390 --> 00:21:22,730
+وفي الـ Quantitative اللي يعني أنهنفس البروتين فيه
+
+200
+00:21:22,730 --> 00:21:28,130
+مشكلة، فيه غلط، فيه مرض، فيه إشي هاي بدنا نسميها
+
+201
+00:21:28,130 --> 00:21:32,770
+زي الـ Sickle Cell Anemia الـ Sickle Cell اللي هي
+
+202
+00:21:32,770 --> 00:21:38,810
+راح ناخد الأنيميا المنجالية هذه بتكون مشكلة
+
+203
+00:21:38,810 --> 00:21:45,170
+بالنسبة للـ Type of Hemoglobin نفسه، مش الكمية
+
+204
+00:21:45,170 --> 00:21:50,370
+تبعته، النوعية تبعته وفي نوع أخر اعتبروه اللي هو
+
+205
+00:21:50,870 --> 00:21:59,270
+الـ يعني اللي هو gain of function زي persistence
+
+206
+00:21:59,270 --> 00:22:04,990
+of hemoglobin ويكون higher affinity for the oxygen
+
+207
+00:22:04,990 --> 00:22:12,910
+الآن الـ eight steps كيف الـ mutation بتتحول ل
+
+208
+00:22:12,910 --> 00:22:16,890
+disease causing it can be at the level of the
+
+209
+00:22:16,890 --> 00:22:23,700
+transcription فمثلا التلسيميايا إما الـDeletion of
+
+210
+00:22:23,700 --> 00:22:32,680
+the gene itself أو Absent Production of the
+
+211
+00:22:32,680 --> 00:22:38,920
+Globulin Messenger RNA أو Deletions أو Mutations
+
+212
+00:22:38,920 --> 00:22:42,280
+in the Regularity أو Supply Sites of the Globulin
+
+213
+00:22:42,280 --> 00:22:49,000
+gene يعني بطريقة ما عبارة عن هنا Decrease
+
+214
+00:22:51,690 --> 00:22:57,150
+«ترانسكрипشن» من تلك الجينة «Herditary Persistence
+
+215
+00:22:57,150 --> 00:23:04,650
+of Fetal Hemoglobin» هذه النوعية خللت بطريقة أخرى
+
+216
+00:23:04,650 --> 00:23:11,930
+إنه فيه إشي كان موجود الأصل إنه يكون مش موجود يعني
+
+217
+00:23:11,930 --> 00:23:17,130
+إن هذا كان الأصل إنه ما يكونش موجودبس إنه يظل بعد
+
+218
+00:23:17,130 --> 00:23:24,350
+الوقت المناسب له هذا يعني تسبب للمرض الـ
+
+219
+00:23:24,350 --> 00:23:30,390
+Translation اللي هي تحويل الـ RNA إلى البروتين
+
+220
+00:23:30,390 --> 00:23:39,890
+قولتت بتاع الـGene فما أيه برضه ممكن نتيجة يعني
+
+221
+00:23:39,890 --> 00:23:46,890
+مثال على الـ Thalassemia واللي هون حكوهميكانيزم أو
+
+222
+00:23:46,890 --> 00:23:53,310
+ممكن أن يكون هناك ميكانيزمات باثوجينيتيك أو ممكن
+
+223
+00:23:53,310 --> 00:23:54,330
+أن يكون هناك ميكانيزمات باثوجينيتيك أو ممكن أن
+
+224
+00:23:54,330 --> 00:23:54,830
+يكون هناك ميكانيزمات باثوجينيتيك أو ممكن أن يكون
+
+225
+00:23:54,830 --> 00:23:55,630
+هناك ميكانيزمات باثوجينيتيك أو ممكن أن يكون هناك
+
+226
+00:23:55,630 --> 00:24:00,890
+ميكانيزمات باثوجينيتيك أو ممكن أن يكون هناك
+
+227
+00:24:00,890 --> 00:24:03,570
+ميكانيزمات باثوجينيتيك أو ممكن أن يكون هناك
+
+228
+00:24:03,570 --> 00:24:04,990
+ميكانيزمات باثوجينيتيك أو ممكن أن يكون هناك
+
+229
+00:24:04,990 --> 00:24:09,370
+ميكانيزمات باثوجينيتيك أو ممكن أن يكون هناك
+
+230
+00:24:09,370 --> 00:24:16,790
+ميكانيزمات باثوجينيتيك أو مالـ ما نقول شو هما الـ
+
+231
+00:24:16,790 --> 00:24:19,670
+الـ Amino Acids اللي هو اسمه الـ Primary Structure
+
+232
+00:24:19,670 --> 00:24:23,630
+بعدين كنا بتحول لSecondary Structure تارشير
+
+233
+00:24:23,630 --> 00:24:29,950
+Structure لQuaternal Structure التشكل الرابعي
+
+234
+00:24:29,950 --> 00:24:39,230
+للبروتين فالـ Folding الأول هو الـ Secondary
+
+235
+00:24:39,230 --> 00:24:42,450
+Structureالـ Amino Acid Sequence و الـ Primary
+
+236
+00:24:42,450 --> 00:24:46,510
+Structure الـ Folding و الـ Relationship Between
+
+237
+00:24:46,510 --> 00:24:53,210
+Nearby Amino Acids بيسموه الـ Secondary Structure
+
+238
+00:24:53,210 --> 00:24:58,290
+وبتكون نتيجة أنه بعد ما تولنا الـ Amino Acid Chain
+
+239
+00:24:58,290 --> 00:25:02,410
+لازم تتلف وتعمل الأشياء اللي لازم تتعملها
+
+240
+00:25:02,410 --> 00:25:07,420
+فبقولولكم هنا More than 70%والـ Hemoglobinopaties
+
+241
+00:25:07,420 --> 00:25:10,940
+هم بسبب همogloبين غير عادلين مع تغيير الـ Amino
+
+242
+00:25:10,940 --> 00:25:18,600
+Acid زي الـ Hemoglobin Hammersmith وبعدين في عندي
+
+243
+00:25:18,600 --> 00:25:24,220
+Post-Translational Modification يعني مثلًا بعد ما
+
+244
+00:25:24,220 --> 00:25:28,840
+يخلص البروتين ويصير يعمل Goldie الأصل إن أنا أصير
+
+245
+00:25:28,840 --> 00:25:34,460
+مثلًا في أماكن معينة أحط Glucose أو Carbohydrate
+
+246
+00:25:43,120 --> 00:25:49,100
+بعض الأمراض، وسيضعون عليها مثلًا «مانوز سيكس
+
+247
+00:25:49,100 --> 00:25:57,240
+فوسفات» إبارة عن «مانوز» يعني سكر الموز بيكون معاه
+
+248
+00:25:57,240 --> 00:26:02,820
+فوسفات تنضج في مكان معين ضروري عشان الـ lysodomal
+
+249
+00:26:02,820 --> 00:26:10,160
+storageوبالتالي بيسبب Disease يعني هنا المشكلة في
+
+250
+00:26:10,160 --> 00:26:15,360
+step post-translational بعد ما كوّننا الـVolume
+
+251
+00:26:15,360 --> 00:26:18,420
+بتاعي وصار لها الـFolding الأصل يكون Modification
+
+252
+00:26:18,420 --> 00:26:23,040
+معينة ما بيصير بعدين
+
+253
+00:26:23,040 --> 00:26:32,300
+طبعاً الـTertiary Structure اللي هو الشكل الأخير
+
+254
+00:26:32,300 --> 00:26:40,030
+تبع البروتينبعد ما يكون في عنا يعني interaction
+
+255
+00:26:40,030 --> 00:26:46,110
+between amino acids which are separate يعني الـ
+
+256
+00:26:46,110 --> 00:26:50,290
+secondary structure اللي هو الـ Alpha Helix أو الـ
+
+257
+00:26:50,290 --> 00:26:56,170
+Beta Bleated Sheets هدولة بيكونوا مع الـ يعني
+
+258
+00:26:56,170 --> 00:26:59,630
+interaction between nearby amino acids كل واحد مع
+
+259
+00:26:59,630 --> 00:27:04,890
+اللي بجاره كيف بيترابط بطريقة مختلفةاللي لما يكون
+
+260
+00:27:04,890 --> 00:27:10,370
+الـ Amino Acid بعيدة وترتبط بالذات بالـ disulphide
+
+261
+00:27:10,370 --> 00:27:18,590
+bond بين الـ cytosine أماينو أسد ريزيوز بعيدة عن
+
+262
+00:27:18,590 --> 00:27:23,690
+بعض وتشبك مع بعض هذه بدنا نعتبرها tertial
+
+263
+00:27:23,690 --> 00:27:28,730
+structure وبالتالي assembly of monomers into
+
+264
+00:27:28,730 --> 00:27:34,780
+holomeric protein أحيانًازي وطبعاً هنا يعني
+
+265
+00:27:34,780 --> 00:27:42,520
+تعتبروها أنه التلت أو الـ Interaction يكون بين نسخ
+
+266
+00:27:42,520 --> 00:27:47,300
+متشابهة تماماً من الـ Bollywood بتاع الـ Chairs زي
+
+267
+00:27:47,300 --> 00:27:51,660
+الـ Collagen Triple Helix إذا بتتركوا Structure
+
+268
+00:27:51,660 --> 00:27:55,420
+تبع الـ Collagen فطبعاً الأمراض اللي بيكون فيها
+
+269
+00:27:55,420 --> 00:28:00,760
+Collagen Disease زي مثلاًمعرفة عن سيندروم
+
+270
+00:28:00,760 --> 00:28:06,300
+أهلردانلوس سيندروم أشياء زي هيك بتكون البروتين
+
+271
+00:28:06,300 --> 00:28:14,180
+شكله ويكون انه كل الجين اللي هو من تلت جدائل
+
+272
+00:28:14,180 --> 00:28:19,400
+مربوطات مع بعض في أحيانًا subcellular localization
+
+273
+00:28:19,400 --> 00:28:24,200
+of a polypeptide أو a holomer يعني زي الـfamily
+
+274
+00:28:24,200 --> 00:28:29,750
+الـhypercholesteric mutation مثلًاوين البروتين هذا
+
+275
+00:28:29,750 --> 00:28:34,310
+يعرف في القليل وين يقول هذا برضه أحيانًا بيكون فيه
+
+276
+00:28:34,310 --> 00:28:38,730
+defect Co-factor or prostatic group of binding to
+
+277
+00:28:38,730 --> 00:28:42,790
+a polypeptide يعني أحيانًا حتى يشتغل بالذات
+
+278
+00:28:42,790 --> 00:28:50,310
+الإنزيمات بدنا Co-factor الـ Polypeptide chain
+
+279
+00:28:50,310 --> 00:28:59,350
+يسموها الـ enzyme donorوالـ Apoenzyme أو اللي هو
+
+280
+00:28:59,350 --> 00:29:03,970
+الـ الـ small أو الـ cofactor بيكون هو الإشي
+
+281
+00:29:03,970 --> 00:29:10,790
+الصغير المطلوب عشان كل أنزايم أو بروتين يشتغل
+
+282
+00:29:10,790 --> 00:29:18,590
+أحياناً الـ mutation بتضرب هذا الـ interaction بين
+
+283
+00:29:18,590 --> 00:29:25,440
+الـ الـ quality بتاع الـ chain معالـ Co-Factor
+
+284
+00:29:25,440 --> 00:29:29,220
+المطلوب يعني
+
+285
+00:29:29,220 --> 00:29:32,360
+النتال
+
+286
+00:29:32,360 --> 00:29:38,860
+الأخير اللي هو زي الـ Sickle Cell ماشي أو غيره
+
+287
+00:29:38,860 --> 00:29:45,260
+كمسي كمسي هيمoglobin يكون أن الـ Function زادت
+
+288
+00:29:45,260 --> 00:29:50,720
+نتيجة أن البروتين
+
+289
+00:29:50,720 --> 00:29:58,790
+زاد في الـ Amountأو شغله صار أقوى وأكثر من ما هو
+
+290
+00:29:58,790 --> 00:30:06,910
+مطلوب راح نأخد أمثلة عليها فهدولة الأمثلة على كيف
+
+291
+00:30:06,910 --> 00:30:15,730
+بنحول أو يعني الأنواع التمانية من التأثيرات يا إما
+
+292
+00:30:15,730 --> 00:30:19,170
+الـMutation بتأثر على الـTranscription أو
+
+293
+00:30:19,170 --> 00:30:24,120
+Translation أو على الـFoldingأو على الـ Post
+
+294
+00:30:24,120 --> 00:30:29,240
+-Translational Modification أو على الـAssembly of
+
+295
+00:30:29,240 --> 00:30:35,180
+the monomers into holomers أو الـSubcellular يعني
+
+296
+00:30:35,180 --> 00:30:39,020
+الـMore Advanced Points about الـFunction of the
+
+297
+00:30:39,020 --> 00:30:43,700
+Protein اللي هي الـSubcellular Localization أو
+
+298
+00:30:43,700 --> 00:30:47,900
+الـInteraction مع الـCore Factor أو إنه يصير اندي
+
+299
+00:30:47,900 --> 00:30:53,940
+زيادة أو تغيير الـFunctionبشكل مختلف تماماً كوظيفة
+
+300
+00:30:53,940 --> 00:30:58,960
+مثال على ذلك الـ Sick and Sick راح نحكي عنه في
+
+301
+00:30:58,960 --> 00:31:05,020
+سؤال اتفضلي
+
+302
+00:31:05,020 --> 00:31:13,460
+يا سعاد شو دكتور أحمد؟ خلي سعاد تحكي الله عفوك يا
+
+303
+00:31:13,460 --> 00:31:18,350
+دكتور الله عفوكأول إشي بدي أسأله إنه إحنا حكينا
+
+304
+00:31:18,350 --> 00:31:22,190
+بما إنه فيه 70% من الـMutations الخاصة بالموضوع
+
+305
+00:31:22,190 --> 00:31:26,170
+هذا اللي هي الـNormal in Britain متعلقة بالـBlood
+
+306
+00:31:26,170 --> 00:31:28,670
+عشان هيك أنت الأمثلة اللي ضربتها كلها علاقة
+
+307
+00:31:28,670 --> 00:31:36,690
+بالـBlood لأ، افهمي علينا إحنا اللي حكيناها إحنا
+
+308
+00:31:36,690 --> 00:31:44,370
+اليوم بدنا ندرس كيف الـMutation تتحول لـDisease،
+
+309
+00:31:44,370 --> 00:31:50,460
+ماشي؟فالـ Chapter هذا بالذات المرة هذه مركزين على
+
+310
+00:31:50,460 --> 00:31:54,680
+الدم والأمراض التانية والمشاكل التانية حاطينها في
+
+311
+00:31:54,680 --> 00:31:58,540
+الـ Chapter اللي راح نطلعه بعد دكتوراه فبالنسبة
+
+312
+00:31:58,540 --> 00:32:04,300
+للدم يعني مثلا لو سألتي فصائل الدم كام واحد كام
+
+313
+00:32:04,300 --> 00:32:11,440
+نوع إحنا اللي بتعرفوه الـ ABO و الـ Rh صح؟ صح؟
+
+314
+00:32:11,440 --> 00:32:15,900
+الشيخ اللي بتعرفه الغالب؟في حوالي 600 نوع Blood
+
+315
+00:32:15,900 --> 00:32:21,980
+Groups في 600 نوع من الـ Blood Groups دولة الأشياء
+
+316
+00:32:21,980 --> 00:32:25,820
+اللي بنسميه Blood Group لسه في أنواع كثيرة وكل
+
+317
+00:32:25,820 --> 00:32:30,820
+واحد يمكن أشياء نادرة جدا بس موجودة في هذه الكتب
+
+318
+00:32:30,820 --> 00:32:34,280
+وإذا الواحد بدي تعامل مع المرضى والناس والمجتمع
+
+319
+00:32:34,280 --> 00:32:37,640
+بدي أكون هيك على انتباه إنه فيه إشي اسمه Blood
+
+320
+00:32:37,640 --> 00:32:42,740
+Groups مختلفة الآن أنواع الـ Hemoglobin Obesity
+
+321
+00:32:43,540 --> 00:32:52,060
+كـGenetic Diseases كأمراض دم وراثية مش أمراض دم من
+
+322
+00:32:52,060 --> 00:32:58,180
+أنواع تانية يعني نتيجة Cancer، نتيجة Nutritional
+
+323
+00:32:58,180 --> 00:33:02,480
+Deficiency، نتيجة Autoimmune Disease، مش
+
+324
+00:33:02,480 --> 00:33:06,240
+الـPathologies التانية، احنا بنحكي الـGenetic الآن
+
+325
+00:33:06,240 --> 00:33:10,360
+بتبسمهم زي ما حكينا فيه Quantitative
+
+326
+00:33:10,360 --> 00:33:13,120
+وQualitative……………………………………………………………………………………………………………………………………………………………………�
+
+327
+00:33:13,410 --> 00:33:19,410
+Blood Disease فالآن الـ من يعني الآن حتى لما نقول
+
+328
+00:33:19,410 --> 00:33:23,830
+ثلاثيميا أو Sickle Cell هدولة Big Groups ويلهن
+
+329
+00:33:23,830 --> 00:33:29,690
+أشكال وأنواع وأنواع وفي لسه في أنواع أمراض Under
+
+330
+00:33:29,690 --> 00:33:35,210
+ومش مطلوب إنك تعرفها بس على الـ Bolivar Tide
+
+331
+00:33:35,210 --> 00:33:40,110
+Folding في سبعين Hemoglobinopathy تانية كمان
+
+332
+00:33:40,110 --> 00:33:48,040
+مابدناش ندخل فيهمبس كثير منهم لها علاقة بتلوى الـ
+
+333
+00:33:48,040 --> 00:33:52,340
+«Globule Polypeptide Chain» اللي هو الـ «Holding»
+
+334
+00:33:52,340 --> 00:33:57,120
+أغلبها كانوا «Holding» أه، ماشي طيب، دكتور، إحنا
+
+335
+00:33:57,120 --> 00:34:00,140
+مطالب مثلا معناه نعرف أنه نوع من الـ «ثلاثيميا» هو
+
+336
+00:34:00,140 --> 00:34:03,400
+اللي بيعمل الـ هو اللي بيكون سبب الـ «Mutation» أو
+
+337
+00:34:03,400 --> 00:34:07,320
+اللي جعله «ثلاثيميا» مطالبين لإيش إذا شغل ما أنت
+
+338
+00:34:07,320 --> 00:34:11,810
+بترجع تسألي إسألي إن أنت كان مش فاهم أيشأما إذا
+
+339
+00:34:11,810 --> 00:34:17,910
+مطالبين أو مش مطالبين للامتحانات ماشي يعني الإنسان
+
+340
+00:34:17,910 --> 00:34:22,810
+إذا الواحد طبيب وإن شاء الله بس تخلصي تنطلق في هذه
+
+341
+00:34:22,810 --> 00:34:28,690
+الحياة وتشوف ناس وتشوف تعالجي وبدك تسير تسوي كل ما
+
+342
+00:34:28,690 --> 00:34:33,680
+الواحد يكون عنده فهم أحسنبكون أنت دكتور أفضل بيقدر
+
+343
+00:34:33,680 --> 00:34:39,420
+يعالج أفضل بنتبه للأشياء التداخلات مع بعض أما
+
+344
+00:34:39,420 --> 00:34:45,920
+الأساس مطلوب مش مطلوب يعني أنا كمعلوم أنه فيه 70
+
+345
+00:34:45,920 --> 00:34:52,200
+مرتبطة بهذه أه جيد الواحد يمكن يشوف حالة وبعدين
+
+346
+00:34:52,200 --> 00:34:59,290
+ييجي يفحص مثلا mutation في الـDNA مايلقيهاشبس
+
+347
+00:34:59,290 --> 00:35:03,230
+الحالة وراثية، يعني العيلة مصابة ومافيش غيرهم
+
+348
+00:35:03,230 --> 00:35:09,950
+مصابين وبشكل معين، ممكن يكون جزء من الأنواع الأندر
+
+349
+00:35:09,950 --> 00:35:14,970
+اللي مختلفة فأنا ما بطلب منكم ترجعوا على الـ
+
+350
+00:35:14,970 --> 00:35:21,350
+Mandalian Inherited Disease Database بالـ PubMed
+
+351
+00:35:21,350 --> 00:35:26,430
+وأقولك روح دورلي شو هم ولا شو أنواعهم، لأ، لأ،
+
+352
+00:35:26,430 --> 00:35:30,910
+شغلي نادرة جداًبدوا الواحد دايماً يفهم الـBiggest
+
+353
+00:35:30,910 --> 00:35:37,050
+Principles المبادئ الأكبر يعني، ماشي؟ فلا تسألي
+
+354
+00:35:37,050 --> 00:35:40,990
+مطلوب ولا مش مطلوب، إذا في شيء مش واضح، يعني هدول
+
+355
+00:35:40,990 --> 00:35:45,110
+السبعين اللي بيحكوا عنهم، يمكن في الدنيا كلها، كل
+
+356
+00:35:45,110 --> 00:35:49,690
+واحد منهم بتتكلم عن حالة حالتان، أسرة أسرتين، لقوة
+
+357
+00:35:49,690 --> 00:35:52,930
+ما يجي، في كذا، في كذا، في كذا، وراح نضرب أمثلة
+
+358
+00:35:52,930 --> 00:36:02,940
+عليهم، يعني على أشياءفي أسئلة في إشي مش واضح كمان؟
+
+359
+00:36:02,940 --> 00:36:10,780
+طيب بالنسبة
+
+360
+00:36:10,780 --> 00:36:20,920
+لك مبدأ آخر ماشي اللي هي قضية أنه يعني هيك الواحد
+
+361
+00:36:20,920 --> 00:36:28,000
+يفهمها فهم أنه أحيانًاالـ Diseases هي نتيجة
+
+362
+00:36:28,000 --> 00:36:35,120
+Allelic Heterogeneity أو Locus Heterogeneity يعني
+
+363
+00:36:35,120 --> 00:36:38,940
+هنا بالذات،
+
+364
+00:36:38,940 --> 00:36:43,920
+يعني دخلوها بالنسبة للـ Hemoglobin Obesity بالذات،
+
+365
+00:36:43,920 --> 00:36:55,040
+ماشي، قضية اللي هي إنه بالنسبة لمثلًا الـالـ Beta
+
+366
+00:36:55,040 --> 00:36:59,320
+-thalassemia أو بلاش الـ Sickle Cell Anemia إذا
+
+367
+00:36:59,320 --> 00:37:04,280
+بتتذكر يعني فيه الـ Hemoglobin الطبيعي الـ Beta
+
+368
+00:37:04,280 --> 00:37:12,180
+-Chain وفيه الـ Abnormal ففيه واحد ايه مثلا الـ
+
+369
+00:37:12,180 --> 00:37:15,420
+Hemoglobin A هذا هو الـ Normal والـ S Hemoglobin
+
+370
+00:37:15,420 --> 00:37:19,780
+هو الـ Abnormal وبالتالي فيه هنا بيسموه الـ
+
+371
+00:37:19,780 --> 00:37:26,060
+Allelic Heterogeneity بس أحياناًراح نخرج إنه فيه
+
+372
+00:37:26,060 --> 00:37:34,120
+Alpha-1 وAlpha-2 مثلاً في مرات في نفس الـ Protein
+
+373
+00:37:34,120 --> 00:37:37,840
+زي الـ Hemoglobin لأنه Alpha و Beta-Chain في تداخل
+
+374
+00:37:37,840 --> 00:37:43,560
+بين أكثر من Locus بحيث إنه إشي معايشي بيكون أشد
+
+375
+00:37:43,560 --> 00:37:48,500
+أكتر من سبب للمرض وإشي معايشي بيكون أخف وأحسن
+
+376
+00:37:48,500 --> 00:37:56,040
+للمرض فأحيانًا إذا بتدخلأكتر من الـ locus طبعاً كل
+
+377
+00:37:56,040 --> 00:38:01,420
+الـ locus إله قليل إله بدائل بحيث إنه البدائل
+
+378
+00:38:01,420 --> 00:38:06,880
+الموجودة تتدخل في قضية الـ genetic heterogeneity
+
+379
+00:38:06,880 --> 00:38:15,520
+الآن هذا مستوى من التعقيد والاختلافات إنه يكون
+
+380
+00:38:15,520 --> 00:38:21,440
+عنده كل القليل مختلف كل الجين نفسه كـ DNA فيه
+
+381
+00:38:21,440 --> 00:38:27,160
+اختلافاتبس أحيانًا الـ… الـHeterogeneity
+
+382
+00:38:27,160 --> 00:38:31,780
+Phenotypic يعني اللي أتكلمنا على الـPenetrance
+
+383
+00:38:31,780 --> 00:38:38,280
+أتكلمنا على Other Modifications بحيث أنه أحيانًا
+
+384
+00:38:38,280 --> 00:38:45,480
+نفس الجين أو نفس الـLocus بس بيصير عندي Variation
+
+385
+00:38:45,480 --> 00:38:49,880
+في الـPhenotype اللي أنا بشوفهفهي مبدأ يعني أنا
+
+386
+00:38:49,880 --> 00:38:57,520
+بعتبر إنه تكرار لإيش قديم أخدناه بالنسبة لـ
+
+387
+00:38:57,520 --> 00:39:04,480
+Structure of the hemoglobin subunit يكون هذه ناحية
+
+388
+00:39:04,480 --> 00:39:13,300
+مهمة كثيرة الآن هذه الصورة هي three-dimensional
+
+389
+00:39:13,300 --> 00:39:20,600
+structure لـالـ One Hemoglobin Unit فما بدك
+
+390
+00:39:20,600 --> 00:39:25,640
+تتذكروا إنه الـ Hemoglobin الصبغة الحمرة اللي في
+
+391
+00:39:25,640 --> 00:39:29,800
+الدم اللي بتعطي اللون الدم الأحمر وظيفتها حملة
+
+392
+00:39:29,800 --> 00:39:37,980
+الأكسجين عبارة عن أربع Globin Units الأربع Globin
+
+393
+00:39:37,980 --> 00:39:45,900
+Units Two Alphas وTwo Betas الـ Globin يعني إشي
+
+394
+00:39:45,900 --> 00:39:54,830
+كرميعني إشي Globular بشكل زي الطب زي الـ Cut يعني
+
+395
+00:39:54,830 --> 00:39:59,030
+مجموعة طبعاً زي الـ Immunoglobulin أو الـ
+
+396
+00:39:59,030 --> 00:40:04,650
+Hemoglobin حتى يظل بهذا الـ Structure لازم يكون
+
+397
+00:40:04,650 --> 00:40:09,690
+بين قوسين فيه Disulphide Bond لازم يكون فيه إشي
+
+398
+00:40:09,690 --> 00:40:18,430
+بالنص يعني حتىطبّة حبل، طبّة سلك، بدك تمسكها على
+
+399
+00:40:18,430 --> 00:40:22,810
+شكل كروي، بالأخير لازم تحط إشي حتى يمسكها بهذا
+
+400
+00:40:22,810 --> 00:40:31,630
+الشكل، فلو حكينا إحنا بالنسبة لما نقول بالنسبة
+
+401
+00:40:31,630 --> 00:40:37,390
+للـ secondary structure للبروتين، فعندي Alpha
+
+402
+00:40:37,390 --> 00:40:42,010
+Helix اللي هو بلف على شكل، لما يناسب، بتلف على شكل
+
+403
+00:40:42,790 --> 00:40:48,410
+بتصير حبل غليظ كثير وملتوى على نفسه أو Beta-plated
+
+404
+00:40:48,410 --> 00:40:53,150
+sheets بيكون خط رايح أو خط جاي بحيث بيعطينا زي شكل
+
+405
+00:40:53,150 --> 00:40:59,470
+الورقة أو سطح إشي هيك مستوي فالـ Hemoglobin اللي
+
+406
+00:40:59,470 --> 00:41:06,430
+بدنا نتذكره في الـHelicytes بيسموها Alpha وBeta A
+
+407
+00:41:06,430 --> 00:41:14,160
+وB وC وD وE وH وJ وكدهبدي يكون بهذا الشكل ماشي
+
+408
+00:41:14,160 --> 00:41:19,100
+وترتيب الـ Folding بتبعه بهذا الشكل هاي بالـ X-Ray
+
+409
+00:41:19,100 --> 00:41:24,380
+Crystallography بتقدر الواحد يشوفها وهي قضية
+
+410
+00:41:24,380 --> 00:41:30,340
+مرتبطة بالـ Primary Structure إنه بتخليه يفضل إنه
+
+411
+00:41:30,340 --> 00:41:36,700
+يكون يستقر على هذا الشكل بنلاحظ فيه Dysulfide Bond
+
+412
+00:41:36,700 --> 00:41:44,030
+وباعتبره هنا إنهالـ Phenylalanine at position 42
+
+413
+00:41:44,030 --> 00:41:50,830
+وتقريبًا 150 Amino Acid ماشي، يعني 147 يعني بالضبط
+
+414
+00:41:50,830 --> 00:41:57,270
+بالضبط حاطين رقم، ماشي 150 Amino Acid بلف بهذا
+
+415
+00:41:57,270 --> 00:42:03,670
+الشكل، ماشي في الـ Phenylalanine at position 42
+
+416
+00:42:03,670 --> 00:42:12,050
+مرتبط مع الهستدينبالـ Position 92 فيه Dysulfide
+
+417
+00:42:12,050 --> 00:42:17,950
+Bond أو فيه رابطة هنا زائد الـ Heme Structure الـ
+
+418
+00:42:17,950 --> 00:42:27,930
+Heme هذا عبارة عن اللي هو ببدأ من يعني اللي يعني
+
+419
+00:42:27,930 --> 00:42:32,570
+لما نتحطم هو بروفايرول الـ Ring إشي بالـ
+
+420
+00:42:32,570 --> 00:42:36,590
+Biochemistry اللي راح تخلوه عبارة عن Ring كبيرةلما
+
+421
+00:42:36,590 --> 00:42:40,830
+تتكسر تعطينا الـ bilirubin والـ biliverdin بس
+
+422
+00:42:40,830 --> 00:42:45,170
+missed الـ hemoglobin الـ hem molecule أو الـ hem
+
+423
+00:42:45,170 --> 00:42:51,530
+ring أنه بالأخير بنصها راح تيجي الـ iron atom و
+
+424
+00:42:51,530 --> 00:42:57,810
+لازم تكون الـ iron at plus two يعني فرس مش فرق مش
+
+425
+00:42:57,810 --> 00:43:01,830
+plus three إذا صارت plus three راح يصير met
+
+426
+00:43:01,830 --> 00:43:07,330
+hemoglobin وبشتغلش كويس، مايفيدشوالـ Iron هو اللي
+
+427
+00:43:07,330 --> 00:43:15,870
+بيحمل الـ Oxygen فهي هي الـ Structure تبع One Unit
+
+428
+00:43:15,870 --> 00:43:22,310
+of Hemoglobin فبنسميها الـ Hemoglobin Subunit فيه
+
+429
+00:43:22,310 --> 00:43:27,170
+ثنتين Alpha وثنتين Beta الأربعة بيشتركوا مع بعض
+
+430
+00:43:27,170 --> 00:43:31,830
+فيهم أربعة Hem أربعة Iron وبيمسكوا الـ Oxygen
+
+431
+00:43:31,830 --> 00:43:36,300
+وبيحملوا الـ Oxygen وينقلوا خدسةفهذه الـ Structure
+
+432
+00:43:36,300 --> 00:43:46,760
+تبع الـ الـ الـ Hemoglobin و Sub-unit وبيركزوا على
+
+433
+00:43:46,760 --> 00:43:52,040
+إنه يعني حتى يظل الـ Structure بهذا الشكل لازم
+
+434
+00:43:52,040 --> 00:43:54,860
+يمسك دائر الـ Sulphide Bond لازم يكون فيه Bond
+
+435
+00:43:54,860 --> 00:44:03,220
+قوية وفيه pocket زي جيبة لأي محل حتى يقدر الـ Mem
+
+436
+00:44:03,690 --> 00:44:08,810
+الـ molecule يدخل ويكون الـ iron عليها حتى يمسك
+
+437
+00:44:08,810 --> 00:44:17,090
+الـ oxygen فيها أسئلة؟ في حد عنده سؤال؟
+
+438
+00:44:17,090 --> 00:44:24,730
+طيب فالـ hemoglobin normally it will be like this
+
+439
+00:44:24,730 --> 00:44:35,530
+طيب، لما نيجي ندرس كيف الجينات بالأولتبعته بتشتغل
+
+440
+00:44:35,530 --> 00:44:39,070
+الحكاية
+
+441
+00:44:39,070 --> 00:44:43,710
+اللي حكيناها في عندي أنا two الـ hemoglobin
+
+442
+00:44:43,710 --> 00:44:49,710
+molecule فيه له two subunits فيه Alpha وفيه Beta
+
+443
+00:44:49,710 --> 00:44:56,530
+الـ Alpha في أظن الـ Chromosome 16 إذا قريتها
+
+444
+00:44:56,530 --> 00:45:07,770
+بعدين بنلاحظ أنهأظن أن هذه إيتا الـ Alpha-like
+
+445
+00:45:07,770 --> 00:45:12,930
+genes في عندي Alpha-1 و Alpha-2 في عندي الـ Eta
+
+446
+00:45:12,930 --> 00:45:23,890
+هذه الـ أو Zeta أقل Zeta حرف يوناني أو من الأحرف
+
+447
+00:45:23,890 --> 00:45:30,610
+القديمة و أظن Zeta الآن
+
+448
+00:45:58,330 --> 00:45:59,730
+بالنسبة
+
+449
+00:45:59,730 --> 00:46:01,130
+لـ’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’�
+
+450
+00:46:02,050 --> 00:46:08,990
+والـ Alpha هي جزء من الـ Hemoglobin الـ Beta هي
+
+451
+00:46:08,990 --> 00:46:16,910
+عندي خمسة وواحدة Beta الرئيسية وهنا Epsilon وGamma
+
+452
+00:46:16,910 --> 00:46:25,970
+Delta وA Delta وأسف Gamma G Gamma وA Gamma وI
+
+453
+00:46:25,970 --> 00:46:30,690
+Delta يعني
+
+454
+00:46:31,760 --> 00:46:40,820
+النقطة هذه ماشية بدّي الواحد يعني يربطها بالجدول
+
+455
+00:46:40,820 --> 00:46:48,440
+اللي تحت يعني الـHemoglobin في حياة الإنسان لما
+
+456
+00:46:48,440 --> 00:46:55,100
+نتكلم على مراحله الـEmpirionic Period الـEarly
+
+457
+00:46:55,100 --> 00:47:01,700
+Empirionic Period بعدين الـFeta Life بعدين الـالـ
+
+458
+00:47:01,700 --> 00:47:08,760
+Adult Life أو الـ Later Life الـ Life الحياة بعدين
+
+459
+00:47:08,760 --> 00:47:15,680
+لازم يكون الـ Hemoglobin اللي بتكون عندي مختلف في
+
+460
+00:47:15,680 --> 00:47:25,300
+كل مرحلة السبب واضح يعني السبب أنه أنا لما أكون في
+
+461
+00:47:25,300 --> 00:47:32,430
+بطن أمي وأنا جنينالـ Lungs ما عندي Lungs ما عندي
+
+462
+00:47:32,430 --> 00:47:38,230
+إشي يأخذ الـ Oxygen من الهوى أو من المي كسمكة ولا
+
+463
+00:47:38,230 --> 00:47:43,450
+إشي الـ Hemoglobin اللي أنا بدي أخده الـ Acid الـ
+
+464
+00:47:43,450 --> 00:47:46,710
+Oxygen اللي بدي أخده في حالة الـ embryonic period
+
+465
+00:47:46,710 --> 00:47:52,510
+أو الـ fetal period بيجي من وين؟ بيجي من الأم بيجي
+
+466
+00:47:52,510 --> 00:47:57,870
+من الـ machine الـ placenta اللي بيصير فيها إنه
+
+467
+00:47:57,870 --> 00:48:05,760
+بقتربدم الجنين مع دم الأم فإذا في المرحلة الجنينية
+
+468
+00:48:05,760 --> 00:48:14,040
+الـ Affinity اللي هي قوة استقطاب وتماسط أو مسك الـ
+
+469
+00:48:14,040 --> 00:48:21,260
+Hemoglobin للـ Oxygen متماثلة مع تبع الأم النتيجة
+
+470
+00:48:21,260 --> 00:48:26,160
+راح تكون إنه أنا مارح أقدر أخذ منها Oxygen ناشي،
+
+471
+00:48:26,160 --> 00:48:32,570
+فبالتاليما بيكون فيه Oxygen للجنين فلازم حتى ينجح
+
+472
+00:48:32,570 --> 00:48:39,270
+الـ Oxygen تبع الجنين أنه يأخذ الـ Oxygen عشان
+
+473
+00:48:39,270 --> 00:48:42,390
+ينجح الـ Hemoglobin تبع الجنين أنه يمسك الـ Oxygen
+
+474
+00:48:42,390 --> 00:48:46,430
+من الـ Hemoglobin تبع الأم لازم تكون الـ Affinity
+
+475
+00:48:46,430 --> 00:48:52,670
+تبعته للـ Oxygen أقوى من تبع الأم فبالتالي احنا في
+
+476
+00:48:52,670 --> 00:48:58,170
+عنا أكثر من نوع من Hemoglobinوالأنواع اللي بتطلع
+
+477
+00:48:58,170 --> 00:49:03,690
+في كل مرحلة لازم تكون نوعية مختلفة وبتكون بهذا
+
+478
+00:49:03,690 --> 00:49:10,630
+الشكل في نقطة يعني أنا بتأكد أكيد مرت عليكم
+
+479
+00:49:10,630 --> 00:49:16,450
+بالنسبة للـElectrophoresis أو اللي هي تكون الدم إن
+
+480
+00:49:16,450 --> 00:49:20,030
+الخلايا اللي بتكون الدم الـMetabiotic Stem Cell
+
+481
+00:49:20,030 --> 00:49:24,640
+والأشياء هذهفي المرحلة الأولى تبدأ في كيس المحة
+
+482
+00:49:24,640 --> 00:49:29,440
+اللي هو الكيس اللي فيه الصفار اللي في البيض بالله
+
+483
+00:49:29,440 --> 00:49:32,980
+فيه اللي هو ما يسمونه الـ Yolksa في مرحلة معينة من
+
+484
+00:49:32,980 --> 00:49:37,700
+حياة الجنين الـ Embryonic، Airy-Embryonic بتكون
+
+485
+00:49:37,700 --> 00:49:44,300
+الدم بتكون في الـ Yolksa بعدين later these cells
+
+486
+00:49:44,300 --> 00:49:48,960
+migrate into the liver وSpleen وكونهم المصدر
+
+487
+00:49:48,960 --> 00:49:54,130
+الأكبروراح نشوف إذا دخل في الأمراض إنه يظل زي في
+
+488
+00:49:54,130 --> 00:49:57,430
+التلاثيمية إنه يظل إلتاج الدم من الـ Liver و
+
+489
+00:49:57,430 --> 00:50:04,050
+الـSpleen بس بالأخير عند الولادة وعادة في بقية
+
+490
+00:50:04,050 --> 00:50:11,250
+حياة الإنسان الدم بتتكون بالبومارو فهذه المراحل
+
+491
+00:50:11,250 --> 00:50:19,940
+اللي من وين تطلع الدم من الإنسانإذا شُفنا أنواع
+
+492
+00:50:19,940 --> 00:50:26,160
+الدم اللي بيكون موجود، ماشي في ملاحظة قريتها لأنه
+
+493
+00:50:26,160 --> 00:50:31,960
+كنت أقرن بارح إنه بالنسبة للـ Alpha والـ Beta
+
+494
+00:50:31,960 --> 00:50:37,820
+-Genes عادة من الـEmpirionic أو Early Empirionic
+
+495
+00:50:37,820 --> 00:50:45,020
+للـFetal للأدلالـ Transcription بيكون بالأول
+
+496
+00:50:45,020 --> 00:50:48,860
+بيستخدم النوع الأول بعدين بيصير يستخدم النوع
+
+497
+00:50:48,860 --> 00:50:53,140
+الثاني أو الثالث اللي دولة مع بعض بس بالنسبة للـ
+
+498
+00:50:53,140 --> 00:50:58,460
+Beta Chain بيبدأ نوع معين بعدين بيصير لنوع ثاني و
+
+499
+00:50:58,460 --> 00:51:05,680
+النوع الثاني بعدين بتحول لنوع ثالث، ماشي؟ يعني
+
+500
+00:51:05,680 --> 00:51:13,980
+إحنا المهماتيعني اللي بدك تذكره أنه أحنا بشكل
+
+501
+00:51:13,980 --> 00:51:21,200
+طبيعي كأدل 95% أو أكثر Hemoglobin A اللي هو Alpha
+
+502
+00:51:21,200 --> 00:51:29,800
+2 Beta 2 أحنا هذا تبعنا كأدل فيه 3، 4، 5% اللي هو
+
+503
+00:51:29,800 --> 00:51:38,890
+A2 اللي هو Alpha 2 Delta 2 بهذا الشكل ماشي؟في
+
+504
+00:51:38,890 --> 00:51:43,750
+الحالة اللي حكيناها اللي هي الـ Persistence of
+
+505
+00:51:43,750 --> 00:51:49,330
+Hemoglobin F الـ Hemoglobin F هي Alpha 2 Gamma 2
+
+506
+00:51:49,330 --> 00:51:56,330
+نوع ثاني من الـ Beta Chain ماشي هدولة الثلاثة اللي
+
+507
+00:51:56,330 --> 00:52:01,810
+بدي أقوم Goer 1 و Goer 2 و Portland يعني Early
+
+508
+00:52:01,810 --> 00:52:06,130
+Empyrionic Period اللي قصد في الموضوع إنه كل ما
+
+509
+00:52:06,130 --> 00:52:11,830
+نمشي من هون لهونالـ Affinity للـ Oxygen بتقل يعني
+
+510
+00:52:11,830 --> 00:52:16,370
+هذا very strongly associated with يعني بمُص الـ
+
+511
+00:52:16,370 --> 00:52:20,490
+Oxygen قوي كتير حتى يقدر يُخض من الـ Ohm و بعدين
+
+512
+00:52:20,490 --> 00:52:27,110
+هنا أحسن شوية أو أخف شوية بس لسه أحسن من الـ A1 أو
+
+513
+00:52:27,110 --> 00:52:33,570
+الـ A و الـ A2 هنا مافيش A1، حاطين A و A2 نلتزم زي
+
+514
+00:52:33,570 --> 00:52:41,030
+ما هم حاكين، فالخلاصة تبع الموضوع هذا أنه أنا
+
+515
+00:52:41,030 --> 00:52:45,010
+بالنسبة للـ Hemoglobin Molecule في عندي Alpha
+
+516
+00:52:45,010 --> 00:52:51,130
+Chain و Beta Chain فنتين فنتين كل واحد فيها هيم
+
+517
+00:52:51,130 --> 00:52:57,050
+هذا الـFull Hemoglobin اللي عندي يعني في اللي
+
+518
+00:52:57,050 --> 00:53:07,230
+بيشترك ضمن يعني إذا بنشوف الـ… الجدول الأخيرماشي،
+
+519
+00:53:07,230 --> 00:53:13,490
+في الـ Empyrionic Period بالنسبة لـ بالأول ببدأ
+
+520
+00:53:13,490 --> 00:53:18,710
+يعني حتى بفترة مبكرة الـ Alpha Chain بيكون هو الـ
+
+521
+00:53:18,710 --> 00:53:23,230
+dominant وطبعاً دي Alpha 1 و Alpha 2 ويكون موجود
+
+522
+00:53:23,230 --> 00:53:26,890
+يمكن نسبة شويه مختلفة ولا كده بس اللي هي الـ Alpha
+
+523
+00:53:26,890 --> 00:53:31,330
+Chain وإنه في الـ Empyrionic Period في إيش اسمه
+
+524
+00:53:31,330 --> 00:53:35,920
+بالنسبة للـ Beta Chain في اسمها الـ Gamma Chainالـ
+
+525
+00:53:35,920 --> 00:53:39,400
+Gamma Chain هي بديل عن الـ Beta Chain ولمّا
+
+526
+00:53:39,400 --> 00:53:43,980
+الإنسان يولد يصير switch في حياته إنه بيبطل يطلع
+
+527
+00:53:43,980 --> 00:53:48,120
+الـ F-Hemoglobin يصير يطلع الـ Alpha الـ A
+
+528
+00:53:48,120 --> 00:53:53,380
+-Hemoglobin والـ Gamma
+
+529
+00:53:53,380 --> 00:54:02,780
+بيبطل يطلع ماشي لحد معين بنلاقي الـ Gamma صار ينزل
+
+530
+00:54:02,780 --> 00:54:08,040
+وذا ظل موجود يبقىراح يا إما يعمل Pick مشكلة أو
+
+531
+00:54:08,040 --> 00:54:12,100
+يحسّي المشكلة تانية، راح نهتز يعني وفيه عندنا
+
+532
+00:54:12,100 --> 00:54:18,300
+بالنسبة بسيطة جداً، 5 بـ2، 3، 4% بدل الـBeta Chain
+
+533
+00:54:18,300 --> 00:54:25,800
+فيه عندي الـDelta Chain اللي راح تعطيني الـA2 فأنا
+
+534
+00:54:25,800 --> 00:54:33,470
+بعتبر هذا الـSlide وهذا الجدول من أهم الجدولوهذا
+
+535
+00:54:33,470 --> 00:54:37,410
+بدي إياكم تفهموا الـ Go where one و two و three أو
+
+536
+00:54:37,410 --> 00:54:41,690
+Portland و الأشياء هذه بديش إياها، هي مش مهمة بس
+
+537
+00:54:41,690 --> 00:54:49,170
+علاقات الـ F و الـ A2 و الـ A و الأنواع المختلفة و
+
+538
+00:54:49,170 --> 00:54:54,170
+كيف ثم بيجوا و كيف التطورها في حياة الإنسان أنا
+
+539
+00:54:54,170 --> 00:54:58,890
+باعتبر هذه أهم الجوانب و لازم واحد يكون مذكرها و
+
+540
+00:54:58,890 --> 00:54:59,610
+فاهمها
+
+541
+00:55:03,130 --> 00:55:10,530
+هذه هي الـ Genetic Basis وهنا الناس، يعني We are
+
+542
+00:55:10,530 --> 00:55:16,230
+describing the normal development of Hemoglobin
+
+543
+00:55:16,230 --> 00:55:23,830
+production بيكون على مراحل مختلفة، لأنواع مختلفة،
+
+544
+00:55:23,830 --> 00:55:31,740
+بالجينات مختلفة واللي بنبه عليه أنه يعني تركيبكأنه
+
+545
+00:55:31,740 --> 00:55:36,540
+فيه حاجة Controller بمرحلة معينة بيخلّي هذا النوع
+
+546
+00:55:36,540 --> 00:55:40,120
+يطلع بعد شويه اللي بعده وبعد شويه اللي بعده
+
+547
+00:55:40,120 --> 00:55:45,320
+بالنسبة للـ Beta-Chain النوع الأول بشكل معين بعدين
+
+548
+00:55:45,320 --> 00:55:49,040
+النوع التاني وبعدين النوع التالف، بهذا الشكل يعني
+
+549
+00:55:49,040 --> 00:55:54,440
+أن الأصل أنه في كل مرحلة بتلاقي نوعية معينة من
+
+550
+00:55:54,440 --> 00:55:58,610
+الـHemoglobin لازم تطلعوبعدين بس يخلص وبنتقل على
+
+551
+00:55:58,610 --> 00:56:03,130
+النوع اللي بعدها حسب الاحتياج وحسب الوضع وحسب حياة
+
+552
+00:56:03,130 --> 00:56:08,990
+الإنسان سبحان الله تفاصيل
+
+553
+00:56:08,990 --> 00:56:16,070
+الـ Beta المعقدة أكتر وبالذات أنواع الـ Genetic
+
+554
+00:56:16,070 --> 00:56:24,050
+Mutation حكينا عنها بالنسبة
+
+555
+00:56:24,050 --> 00:56:31,880
+لـيعني للـ Hemoglobin بذكر مرة ثالثة لما نقول
+
+556
+00:56:31,880 --> 00:56:39,780
+Hemoglobinopathy يا إما نوعية نعتبرها اللي هي
+
+557
+00:56:39,780 --> 00:56:46,500
+Quantitative وفي Qualitative فالـ Qualitative ماشي
+
+558
+00:56:46,500 --> 00:56:54,800
+اللي هي إنه شكل الـ Hemoglobin اختلفما هم نتكلم
+
+559
+00:56:54,800 --> 00:57:00,240
+على بروتين طبيعي وكميته اختلفت، لأ هنا انه صار فيه
+
+560
+00:57:00,240 --> 00:57:08,860
+إشي عملناه مشكلة أهم نوع الـ Hemoglobin-S اللي هو
+
+561
+00:57:08,860 --> 00:57:12,820
+بعطينا Sickle Cell Disease Sickle Cell Disease
+
+562
+00:57:12,820 --> 00:57:18,040
+الـHemoglobin اللي فيه بيسموه Hemoglobin-S وهي
+
+563
+00:57:18,040 --> 00:57:25,560
+Autosomal Recesses اللي بيصيرإنه في الـ يعني لازم
+
+564
+00:57:25,560 --> 00:57:31,440
+واحد يكون يقدر يقرا هذه الـ Notation اللي هي إن
+
+565
+00:57:31,440 --> 00:57:40,060
+الـ Beta Chain الـ Position رقم 6 في الـ Glutamine
+
+566
+00:57:40,060 --> 00:57:44,300
+أظن أن الـ Amino Acid Glutamine بتتحول لـ Valine
+
+567
+00:57:44,300 --> 00:57:49,420
+فهي Amino Acid Substitution وهي لما نكتبوا لكم
+
+568
+00:57:49,420 --> 00:57:54,010
+الأرقام هذهالـ Glutamine position 26 صار Lycine
+
+569
+00:57:54,010 --> 00:58:00,970
+أسبارجين هذا position 99 صار ASM يجب أن يقرأ أحد
+
+570
+00:58:00,970 --> 00:58:06,470
+ما هو الـ Amino Acid نتيجة المشكلة هذه فهذه الـ
+
+571
+00:58:06,470 --> 00:58:11,190
+notation لازم الواحد يعرفها
+
+572
+00:58:11,190 --> 00:58:20,640
+الـ Sickle Cell Disease عبارة عنيعني كيف تبدأ
+
+573
+00:58:20,640 --> 00:58:26,000
+الأمر من الـGenetics
+
+574
+00:58:26,000 --> 00:58:31,280
+لـDisease Phenotype لشو اللي بنشوفه على المريض
+
+575
+00:58:31,280 --> 00:58:34,620
+الـGenetic
+
+576
+00:58:34,620 --> 00:58:41,560
+Basis إنه الـNormal Kodon GAG فبتتحول لسكل سلك
+
+577
+00:58:41,560 --> 00:58:51,030
+كودون تبع GTG بدل الـASRTفالـ Glutamine الـ «جي
+
+578
+00:58:51,030 --> 00:58:56,030
+أليو» اتحول لـ «فالين» هذا الـ «فالين» إذا بتتذكره
+
+579
+00:58:56,030 --> 00:59:03,050
+أظنه Hydrophobic تحب يشيل ميه وهذا Hydrophilic
+
+580
+00:59:03,050 --> 00:59:09,510
+طبعاً يعني سبحان الله ليش الـ Folding تيسير بالشكل
+
+581
+00:59:09,510 --> 00:59:14,410
+هذا؟ إله دخل إنه لما يسير الـ Folding بشكل طبيعي
+
+582
+00:59:14,410 --> 00:59:20,280
+اللي على السطح لازم يكونHydrophilic يعني بيحب
+
+583
+00:59:20,280 --> 00:59:27,140
+الميه واللي جوا بيكون Hydrophobic لأنه بيكون لازم
+
+584
+00:59:27,140 --> 00:59:32,020
+يكره الميه حتى يظلوا جوا ويكونوا جوا عشان مايتعرضش
+
+585
+00:59:32,020 --> 00:59:39,580
+للميه فنتيجة الاختلال هذا من Hydrophilic على
+
+586
+00:59:39,580 --> 00:59:45,000
+Hydrophobic على position معين تصير إنه
+
+587
+00:59:45,000 --> 00:59:50,310
+الـHemoglobin الـSفي حالة لما يكون Oxygenated
+
+588
+00:59:50,310 --> 00:59:54,830
+Hemoglobin في الـRed Blood Cell بتكون
+
+589
+00:59:54,830 --> 01:00:00,470
+الـHemoglobin موليكيولز يتسفرد بالشكل الطبيعي في
+
+590
+01:00:00,470 --> 01:00:06,330
+حالة الـDeoxyhemoglobin ماشي، لما يبطل ويقل نسبة
+
+591
+01:00:06,330 --> 01:00:14,310
+الأكسجين ويتحول إلى Deoxy الـHydrophobic يعني
+
+592
+01:00:14,310 --> 01:00:20,740
+الـPatch كانت تخيل عند الكرافةالأصل الكورات تضربوا
+
+593
+01:00:20,740 --> 01:00:26,680
+بعض وما يكونش فيها أي شيء لأ الكورة اتغيرت بحيث
+
+594
+01:00:26,680 --> 01:00:30,900
+أنه على قطعة منها أو على جانب معين صار إشي بلزق
+
+595
+01:00:30,900 --> 01:00:38,640
+صار إشي sticky فلما يصير ديوكسيهيمoglobin المنطقة
+
+596
+01:00:38,640 --> 01:00:43,060
+اللي بتلزق هذه بتبين أكتر وبتكون أكتر وبنتج عنها
+
+597
+01:00:43,060 --> 01:00:50,220
+أنها بتتجمع فييعني كريستال يعني على شكل بلورة هي
+
+598
+01:00:50,220 --> 01:01:05,280
+إشي كبير وإشي يعني صلب فالأصل الخلية الـ Red blood
+
+599
+01:01:05,280 --> 01:01:09,660
+cells اللي هي Biconcave بهذا الشكل easily
+
+600
+01:01:09,660 --> 01:01:15,270
+deformable يعنيتقدر تتلوى، تقدر تتغير في حالها
+
+601
+01:01:15,270 --> 01:01:21,110
+بحيث أنه تقدر تفوت في أماكن ضيقة فلمّا يصير عندي
+
+602
+01:01:21,110 --> 01:01:27,330
+الشكل السكن اللي هو المنجل بهذا الشكل نتيجة تكوّن
+
+603
+01:01:27,330 --> 01:01:32,110
+crystals من الـHemoglobin-S يصير عندي non
+
+604
+01:01:32,110 --> 01:01:37,600
+-deformability بتبطل، تقدر تتلوىاللي بيصير عندي
+
+605
+01:01:37,600 --> 01:01:42,380
+بيصير vasoclosion فبيصير عندي hemolysis جزء منه
+
+606
+01:01:42,380 --> 01:01:47,220
+وبيصير عندي تسكير بالـ capillaries بالشعيرات
+
+607
+01:01:47,220 --> 01:01:58,800
+الدموية وهذا سبب أساسي في المرض ناشي بالنسبة
+
+608
+01:01:58,800 --> 01:02:05,430
+للـ hemoglobin hemoglobin repressive اللي همالـ
+
+609
+01:02:05,430 --> 01:02:13,070
+نتيجة الـ hemoglobinopathies نتيجة الـ qualitative
+
+610
+01:02:13,070 --> 01:02:20,990
+qualitative في عندي أكثر من نوع بس ده يعني أنا إذا
+
+611
+01:02:20,990 --> 01:02:26,710
+بتذكر الـ hemoglobin S وتفاصيله بيكفي في الـ
+
+612
+01:02:26,710 --> 01:02:33,350
+hemoglobin Hammersmith بيسوي Hemolysis وبكون له
+
+613
+01:02:33,350 --> 01:02:38,500
+Oxygen Affinityبكون عندي «تغيير» مختلف «هيموجلوبين
+
+614
+01:02:38,500 --> 01:02:44,420
+هايتبارد» أو «هيموجلوبين M» بيسمينه بيكون عندي
+
+615
+01:02:44,420 --> 01:02:50,080
+«سيانوسس» ماشي، أحد أسباب أن المريض عنده ذرقاق
+
+616
+01:02:50,080 --> 01:02:58,100
+«كمسي» اللي هو polycythemia «هيموجلوبين E» بيعطينا
+
+617
+01:02:58,100 --> 01:03:04,430
+mild thalassemia فالـ «هيموجلوبين S» هي mutationفي
+
+618
+01:03:04,430 --> 01:03:10,050
+الـ Beta Chain وهيك بيعطينا، والأصل إنها Autosomal
+
+619
+01:03:10,050 --> 01:03:18,690
+Recesses لمن آجي أنا، بالنسبة بالذات لـHemoglobin
+
+620
+01:03:18,690 --> 01:03:24,710
+S ليش مهمة؟ وليش هيك؟ يعني كثير بدرسوها، وطبعاً في
+
+621
+01:03:24,710 --> 01:03:30,650
+كثير نسب مرضى Sickle Cell، والله يعينهمبعمل أمراض
+
+622
+01:03:30,650 --> 01:03:35,210
+كثيرة يعني بيسموهم حتى بيجيك المريض بـ Crisis
+
+623
+01:03:35,210 --> 01:03:42,470
+بيجيك بأزمة يعني وضع مأزوم جداً جداً في منها الـ
+
+624
+01:03:42,470 --> 01:03:48,230
+Painful Crisis يعني نتيجة تسكير القنوات الدم أو
+
+625
+01:03:48,230 --> 01:03:52,950
+الأوعي الدموية بيصير عندنا ألم شديد ونقص ثروية في
+
+626
+01:03:52,950 --> 01:03:57,210
+الأشي نقص ثروية في الدمار في القلب، في الرئتين، في
+
+627
+01:03:57,210 --> 01:04:02,600
+الـفي الرجلين، في الظهر، في كده ويبقى عندنا حتى
+
+628
+01:04:02,600 --> 01:04:08,260
+Infarction وكده وكده فبيسموه Painful Crisis فيه
+
+629
+01:04:08,260 --> 01:04:11,920
+Hemolytic Crisis بالذات يمكن مع بعض الـ Infection
+
+630
+01:04:11,920 --> 01:04:18,140
+أو بيصير إشي بيصير تكسر بالدم كتير فيه A Plastic
+
+631
+01:04:18,140 --> 01:04:24,080
+Crisis إنه من كتر ما البومر أشتغل بيصير عندي إيش
+
+632
+01:04:24,080 --> 01:04:28,900
+اسمه؟failure of the bomber وإن بطل الـ bomber يقدر
+
+633
+01:04:28,900 --> 01:04:33,520
+يشتغل فمنتج عنه aplastic crisis فهدوله كله منه
+
+634
+01:04:33,520 --> 01:04:38,620
+هدوله بيجيكوا حالات راح تيجي في الطوارئ تكون إنت
+
+635
+01:04:38,620 --> 01:04:43,200
+قاعد في الطوارئ يجيك مريض أو إنسان كان طبيعي وصار
+
+636
+01:04:43,200 --> 01:04:47,540
+نتيجة مشكلة مثلا صار عنده infection دخل ب painful
+
+637
+01:04:47,540 --> 01:04:55,690
+crisis أو aplastic أو hemolytic أوطبعًا يعني لو
+
+638
+01:04:55,690 --> 01:05:00,190
+شُفتوا المرضى الـsickle cell دايماً ممكن يوصلوا أن
+
+639
+01:05:00,190 --> 01:05:08,610
+يصيروا يعني عندهم إدمان
+
+640
+01:05:08,610 --> 01:05:13,630
+على المخدرات لأنه دايماً عندهم ألم شديد وبدوا دوة
+
+641
+01:05:13,630 --> 01:05:20,030
+قوية مورفين وغيره وغيره عشان يعالجها أو أنه مثلًا
+
+642
+01:05:20,030 --> 01:05:31,530
+بدخل أنهالـ Cyclers بيصيروا مثلًا بالأول نتيجة
+
+643
+01:05:31,530 --> 01:05:37,930
+بيهم الأطفال بيكون عندهم Spleen وMegaly الـ Spleen
+
+644
+01:05:37,930 --> 01:05:42,770
+بيكون كبير كتير نتيجة إنه الـ Bomber بيحاول يطلع
+
+645
+01:05:42,770 --> 01:05:49,270
+دم ومش ملحق وبيصير مشاكل فيها إنه الـ Bomber بيكون
+
+646
+01:05:50,540 --> 01:05:54,740
+بالأول Hyperactive وبالتالي بيصير عندهم
+
+647
+01:05:54,740 --> 01:05:59,460
+الـSplenomegaly بس لأنه بيصير Auto-infarction
+
+648
+01:05:59,460 --> 01:06:04,080
+بيصير الـOcclusive crises بالـCapillaries in the
+
+649
+01:06:04,080 --> 01:06:07,940
+spleen فبيصير عندهم By the age of eight to ten
+
+650
+01:06:07,940 --> 01:06:14,280
+بيسموه Auto-splenectomy يعني الـSpleen بتحطم من
+
+651
+01:06:14,280 --> 01:06:20,640
+جوافعادة اللي عندهم Sickle Cell على عمر العشر سنين
+
+652
+01:06:20,640 --> 01:06:24,980
+مايحسسش الـSpleen ولو بيجينا نتحسسهم مايلاقيش
+
+653
+01:06:24,980 --> 01:06:29,880
+عندهم أو عندهم Atrophic Spleen أو Spleen ضامر
+
+654
+01:06:29,880 --> 01:06:38,240
+مافيش عندهم Spleen في نقطتين ليش؟ في يعني وراح
+
+655
+01:06:38,240 --> 01:06:43,980
+نشوفها بعد شوية الـHemoglobin S طبعاً إله أنواع
+
+656
+01:06:43,980 --> 01:06:51,120
+يعنيممكن إنسان يكون Carrier يعني نص اللي عنده
+
+657
+01:06:51,120 --> 01:06:56,280
+Hemoglobin S ونصها اللي عنده Disease اللي بنسميه
+
+658
+01:06:56,280 --> 01:07:00,780
+يعني مريض بالـ Sickness and Anemia اللي بيكون عنده
+
+659
+01:07:00,780 --> 01:07:09,000
+SS Hemoglobin يعني الـTintin اللي عنده SAوعنده SA
+
+660
+01:07:09,000 --> 01:07:15,220
+أو SA2 أو يعني نوعيتين مختلفتين هذا الـ Carrier
+
+661
+01:07:15,220 --> 01:07:21,220
+بيكون أحسن الـ Carrier بالذات للـ Hemoglobin S الـ
+
+662
+01:07:21,220 --> 01:07:27,780
+Carrier State في كلام كتير على إن هؤلاء الناس
+
+663
+01:07:27,780 --> 01:07:32,960
+النتيجة إن الـ Hemoglobin S بيكونوا resistant to
+
+664
+01:07:32,960 --> 01:07:39,130
+malariaعشان هيك يعني كملاحظة إذا بتسوي هيك الـ
+
+665
+01:07:39,130 --> 01:07:44,030
+Mapping في العالم للمرضى اللي عندهم Sickle Cell S
+
+666
+01:07:44,030 --> 01:07:49,290
+-Hemoglobin والملاريا بتلاقيهم أشياء مع بعض يعني
+
+667
+01:07:49,290 --> 01:07:52,670
+منطقة حوض البحر اللي قدرهم توصل في أفريقيا في
+
+668
+01:07:52,670 --> 01:07:57,510
+أماكن معينة وإما بتشوف فيه ملاريا كتير بتلاقي نسبة
+
+669
+01:07:57,510 --> 01:08:05,450
+الـHemoglobin S أكترففي ناس يعني في نظرية لكل واحد
+
+670
+01:08:05,450 --> 01:08:09,990
+دقيق إن الـ S-Hemoglobin بيعطي نوع من الـ
+
+671
+01:08:09,990 --> 01:08:16,090
+Resistance للملاريا وفي يعني كلام على إنه لأ لأن
+
+672
+01:08:16,090 --> 01:08:20,830
+الـ Hemoglobin S المشكلة تبعته لما يكون D
+
+673
+01:08:20,830 --> 01:08:26,030
+-Oxyhemoglobin S أما لما يكون Oxyhemoglobin S مش
+
+674
+01:08:26,030 --> 01:08:33,050
+مشكلة كتير يعني إنه علىالمناطق يعني المرتفعات
+
+675
+01:08:33,050 --> 01:08:36,950
+بيكون الـOxygen أقل واحتمالية الـDeoxygenation
+
+676
+01:08:36,950 --> 01:08:42,870
+أكبر وبالتالي ما يكونش موجود بشكل، يعني فيه
+
+677
+01:08:42,870 --> 01:08:47,830
+selection الإختيار الطبيعي اللي هو الـNatural
+
+678
+01:08:47,830 --> 01:08:52,990
+Selection اللي بعتبره يعني بديل عن يعني أو جزء من
+
+679
+01:08:52,990 --> 01:08:59,500
+التفسير ليش الأمور تمشي بهذا الشكلففي عندي أكتر من
+
+680
+01:08:59,500 --> 01:09:07,600
+نوع وعندي هدولة مشاكل بسميهم نتيجة الـHemoglobin
+
+681
+01:09:07,600 --> 01:09:14,220
+ممكن الـHemoglobin S فيه Hemoglobin SC الـC
+
+682
+01:09:14,220 --> 01:09:19,160
+-Hemoglobin نوع لسه آخر على عكس المرضى بيكونوا
+
+683
+01:09:19,160 --> 01:09:24,140
+كويسين إذا فيه Persistence of F-Hemoglobin يعني
+
+684
+01:09:24,140 --> 01:09:28,420
+سبحان اللهكل الأعراض اللي حكيناها للـS-Hemoglobin
+
+685
+01:09:28,420 --> 01:09:33,420
+لما نكون مع الـA بس إذا فيه F وزيادة شويه في الـF
+
+686
+01:09:33,420 --> 01:09:41,440
+الـS بيبطل يسبب مرض يعني في علاقات مع بعض فجزء من
+
+687
+01:09:41,440 --> 01:09:47,220
+الظواهر الـPersistence of Elevated Fetal
+
+688
+01:09:47,220 --> 01:09:52,640
+Hemoglobin Expression يعني في حالاتبدل حتى بعد ما
+
+689
+01:09:52,640 --> 01:09:56,700
+نولد والأصل إن الـF-Hemoglobin يبطل ويتحول للـA
+
+690
+01:09:56,700 --> 01:10:03,320
+-Hemoglobin وبعد شويه يطلع الـA2 هذه ممكن إنها إذا
+
+691
+01:10:03,320 --> 01:10:06,820
+في ضل زيادة أو ارتفاعة الـF-Hemoglobin
+
+692
+01:10:06,820 --> 01:10:10,880
+الـVolumarization الـCrystallization تبع الـS
+
+693
+01:10:10,880 --> 01:10:21,520
+-Hemoglobin بتقلأحسن بالنسبة للـ «سيكلر» ويعني
+
+694
+01:10:21,520 --> 01:10:27,940
+الكلام اللي بحكوه عنه إذا بحطه مثال على إنه الأصل
+
+695
+01:10:27,940 --> 01:10:30,700
+اللي الواحد يشوف الـFeta-Hemoglobin يمشي بهذا
+
+696
+01:10:30,700 --> 01:10:35,300
+الشكل بالذات بعد البرد بتلاقي إنه فيه persistence
+
+697
+01:10:35,300 --> 01:10:41,560
+of F-Hemoglobin ويكون نتيجة هنا اختلال على مستوى
+
+698
+01:10:41,560 --> 01:10:51,570
+الـRNA levelيعني إشي مش بالضرورة مربوط بالـ…
+
+699
+01:10:51,570 --> 01:10:58,230
+مربوط بالـ… يعني الـCoding DNA Anomaly مش Coding
+
+700
+01:10:58,230 --> 01:11:05,610
+DNA، هنا على إشي في الـcontrol على الـDNA
+
+701
+01:11:05,610 --> 01:11:10,650
+Expression، ماشي؟ ففي عندنا Persistence of Fetal
+
+702
+01:11:10,650 --> 01:11:17,240
+Hemoglobinوهذا يعني إله تأثيرات معينة الآن
+
+703
+01:11:17,240 --> 01:11:22,740
+السعادة،
+
+704
+01:11:22,740 --> 01:11:27,400
+أه أحكي فالينا قبل ما ندخل على التلسينية هي هيك
+
+705
+01:11:27,400 --> 01:11:34,200
+حكيت النقاط اللي بديها بالنسبة للـ Sickle Cell أو
+
+706
+01:11:37,110 --> 01:11:41,730
+equalitative في فرط الـquality، hemoglobin-based،
+
+707
+01:11:41,730 --> 01:11:46,510
+آية سعيدة دكتور، في جزئيتي لما حكيت إنه بالمرتفعات
+
+708
+01:11:46,510 --> 01:11:50,150
+بيصير احتمالية إنه يصير الـdeoxygenation أكتر وإن
+
+709
+01:11:50,150 --> 01:11:53,490
+أنا المشكلة عندي في الـsickle cell أنيميا، اللي
+
+710
+01:11:53,490 --> 01:11:56,410
+بالـsickle cell إنه يكون عندي الوجود الـhemoglobin
+
+711
+01:11:56,410 --> 01:12:00,870
+acid اللي هو في هيئة الـdeoxy نعم لأن هو اللي
+
+712
+01:12:00,870 --> 01:12:05,430
+بيكون هو اللي بيعمل الـcrystals و… صحيحما فهمتش
+
+713
+01:12:05,430 --> 01:12:08,730
+أنا إيش بقى بيصير احتمالية الـDX ينقش، الـDX ينقش؟
+
+714
+01:12:08,730 --> 01:12:14,410
+لأ، يعني معناته إنه اللي عنده هاي الـSickles
+
+715
+01:12:14,410 --> 01:12:18,230
+الـHemoglobin بيروحش يعيش على المرتفعات العالية
+
+716
+01:12:18,230 --> 01:12:24,790
+يعني مناطق اللي على المرتفعات يعني بيعيش على إشياء
+
+717
+01:12:24,790 --> 01:12:30,850
+على مستوى سطح البحر يعني مثلًا تقوللي والله الناس
+
+718
+01:12:30,850 --> 01:12:36,180
+اللي عايشين على الـHimalayasفي حد عنده سكل سلة
+
+719
+01:12:36,180 --> 01:12:42,640
+هناك لما أروح أدرسهم بلاقي قليل جدا لأنه مافيش حد
+
+720
+01:12:42,640 --> 01:12:49,460
+يعني عنده سكل ويعني كأنه صار بين قوسين يعني هذه من
+
+721
+01:12:49,460 --> 01:12:53,870
+الظواهراللي الواحد بينتبه لها الانتخاب الطبيعي
+
+722
+01:12:53,870 --> 01:12:59,770
+يعني نتيجة إنه الإنسان عنده ملعق يعني زي ما تقولي
+
+723
+01:12:59,770 --> 01:13:03,810
+اللون
+
+724
+01:13:03,810 --> 01:13:09,730
+الأسمر أو الجلد الأسمر أكتر بقن الشمس فعشان هيك
+
+725
+01:13:09,730 --> 01:13:14,930
+السمار في أفريقيا حوالين خط الاستواق في القطبين
+
+726
+01:13:14,930 --> 01:13:20,080
+مافيش حد أسمر شكل طبيعي بروح كثير فاهمي عليك؟وإذا
+
+727
+01:13:20,080 --> 01:13:24,880
+أبيض وراح على خط الاستواء مثلًا بتلاقي صابه أمراض
+
+728
+01:13:24,880 --> 01:13:32,020
+زي مثلًا cancer of the skin أو بيصير عنده أشياء،
+
+729
+01:13:32,020 --> 01:13:39,080
+شو اسمه؟ ما بيقدرش يعمل adaptation ما بيقدرش يعمل
+
+730
+01:13:39,080 --> 01:13:42,620
+adaptation يعني، أه لأ يعني راح يسببله مرض، فعلى
+
+731
+01:13:42,620 --> 01:13:51,700
+مدى أجيال، على مدىيعني مدى طويل من الذات قبل السفر
+
+732
+01:13:51,700 --> 01:13:57,020
+الطويل وقبل الطب المتقدم والأشياء هذه يعني اللي
+
+733
+01:13:57,020 --> 01:14:03,080
+بيكون عنده cycling يعني إذا في مرض للـ carrier
+
+734
+01:14:03,080 --> 01:14:11,220
+ماشي بيقولوا أنه مع الـ fever بيسيبهم hematuria
+
+735
+01:14:11,220 --> 01:14:16,460
+يعني بيصير عندهمCrystallization بالـ Hemoglobin
+
+736
+01:14:16,460 --> 01:14:21,160
+للـ Carrier مش اللي عنده Disease في الـ Tubules of
+
+737
+01:14:21,160 --> 01:14:25,600
+the kidneys لما يكون عندهم Infection ولا كده لأنه
+
+738
+01:14:25,600 --> 01:14:29,960
+نسبة الـ Oxygen قليل كتير فنسبة الـ
+
+739
+01:14:29,960 --> 01:14:33,580
+Crystallization أكتر في هذا المكان في هذا الوقت
+
+740
+01:14:33,580 --> 01:14:39,840
+بسبب لهم مظهر معين إنه بيصير عندهم مرض آه آه
+
+741
+01:14:42,200 --> 01:14:51,780
+هي كتابة من القرآن الله يعطيك الله الان الموضوع
+
+742
+01:14:51,780 --> 01:15:02,480
+الثاني بدنا نتذكر أنه يعني المبدأ الثاني اللي هو
+
+743
+01:15:02,480 --> 01:15:08,840
+إنه إذا عندي مشكلة في عدد وكمية Normal Alpha أو
+
+744
+01:15:08,840 --> 01:15:16,670
+Beta Chain بدنا نسميه 30فالثلاثيمية هي لما يكون
+
+745
+01:15:16,670 --> 01:15:23,230
+عندي مش qualitative مش خلل في الـquality، لأ خلل
+
+746
+01:15:23,230 --> 01:15:28,350
+في الـquantity، ناشي؟ فالأنواع اللي حكيناها
+
+747
+01:15:28,350 --> 01:15:32,510
+للـBeta وده في Alpha، Beta، هدولة يعني
+
+748
+01:15:32,510 --> 01:15:36,630
+الـHemoglobin Structural Variants لاحظ أنا كلهم
+
+749
+01:15:36,630 --> 01:15:41,250
+Beta Chain يعني مش حاطين مثال على Alpha Chainيكون
+
+750
+01:15:41,250 --> 01:15:49,350
+فيها زي الـSickle، Equalitative الفلسيفية
+
+751
+01:15:49,350 --> 01:15:54,930
+هي لما يكون عندي Abnormalities
+
+752
+01:15:54,930 --> 01:16:02,730
+in the level of the expression of Alpha وBeta
+
+753
+01:16:02,730 --> 01:16:08,110
+chain فهم الـAlpha وBeta normal كـStructure per se
+
+754
+01:16:08,520 --> 01:16:14,080
+بس كعدد و Level فيه Abnormality في عندنا الـ
+
+755
+01:16:14,080 --> 01:16:20,880
+«تلاسيميا» بنقسمهم Alpha و Beta «تلا» ثلاثة
+
+756
+01:16:20,880 --> 01:16:26,580
+«تلاثة» يعني البحر «يميا» Blood يعني كانوا
+
+757
+01:16:26,580 --> 01:16:31,520
+اليونانيين أو كلمة من المصدر اليوناني لدم البحر
+
+758
+01:16:31,520 --> 01:16:37,060
+يعني هيك بدنا ناخدها ويكون يعني جزء منه كما ذكرت
+
+759
+01:16:37,440 --> 01:16:42,500
+الله العليم بفسره رتباطها بالـ Malaria أو يمكن
+
+760
+01:16:42,500 --> 01:16:46,240
+بنقص الأكسجين أو الأكسجين ففي عندنا Beta
+
+761
+01:16:46,240 --> 01:16:52,380
+-thalassemia وفي عندي Alpha-thalassemia، ماشي؟
+
+762
+01:16:52,380 --> 01:17:00,760
+في اللي لما نكون، في عندي إيش اسمه؟ لما نكون عندي
+
+763
+01:17:00,760 --> 01:17:05,120
+Beta-thalassemia، ماشي؟ ويكون عندي Excess of
+
+764
+01:17:05,120 --> 01:17:09,460
+Normal Alpha Chainبسموه إيش بنشوفه تحت الـ
+
+765
+01:17:09,460 --> 01:17:13,720
+Microscope بسموه Heinz Bodies يعني إبارة عن زي هيك
+
+766
+01:17:13,720 --> 01:17:23,700
+نقطة سودة أكتر أو غامقة أكتر في الـ بالنسبة لـ الـ
+
+767
+01:17:23,700 --> 01:17:28,280
+زي الـ Beta-thalassemia الأكثر اللي هم الـ Alpha
+
+768
+01:17:28,280 --> 01:17:36,510
+-thalassemia الـ Alpha-thalassemia هيوهنا Simple
+
+769
+01:17:36,510 --> 01:17:45,590
+Beta-thalassemia يعني هنا زي ما انتوا شايفين فيه
+
+770
+01:17:45,590 --> 01:17:50,110
+عندنا يعني هنا حاطين الـAffected Population
+
+771
+01:17:50,110 --> 01:17:55,910
+الـPlax، الـIndians، الـMediterranean منطقتنا
+
+772
+01:17:55,910 --> 01:18:06,060
+الـAsians، الجبانيين ففيه أكثرمن نوع من الـ
+
+773
+01:18:06,060 --> 01:18:13,540
+Mechanism حتى يعطينا Beta-thalassemia يعني الأكثر
+
+774
+01:18:13,540 --> 01:18:19,520
+أشياء أنه طبعاً يعني الملاحظة كمان نقطة لازم واحد
+
+775
+01:18:19,520 --> 01:18:25,820
+يكون منتبه إليها أنه ممكن عندي أنا Second cell
+
+776
+01:18:25,820 --> 01:18:30,100
+Beta-thalassemia ممكن يصير أو Alpha-thalassemia
+
+777
+01:18:30,590 --> 01:18:35,930
+فعشان هيك يعني بتكون إنه فيه خلالين في نفس الوقت
+
+778
+01:18:35,930 --> 01:18:40,570
+في محالين مختلفان الـ Sickle Cell S-Hemoglobin
+
+779
+01:18:40,570 --> 01:18:46,950
+نتيجة Beta Chain Mutation في مكان معين لإشي معين
+
+780
+01:18:46,950 --> 01:18:52,810
+هذا بيعطينا الـ Beta-Thalassemia الـSLS-Hemoglobin
+
+781
+01:18:52,810 --> 01:18:58,150
+والـBeta-Thalassemia في يعني
+
+782
+01:18:59,300 --> 01:19:05,040
+بالنسبة للـ Beta-thalassemia بشكل عام أشياء مش
+
+783
+01:19:05,040 --> 01:19:10,220
+deletion يعني إذا بتشوفوا شو أنواع المشاكل يعني
+
+784
+01:19:10,220 --> 01:19:15,540
+أنا الشغلات المعقدة مديش أدخل فيها أنا مش حافظها
+
+785
+01:19:15,540 --> 01:19:20,560
+يعني أو مش منتبئلها، شايف عليك؟ بس لاحظوا أهم نقطة
+
+786
+01:19:20,560 --> 01:19:25,680
+إنه مش deletion اللي هي بتوقعوا في الـAlpha
+
+787
+01:19:25,680 --> 01:19:35,240
+-thalassemiaالشغل التاني كنوع Specific للـ Defect
+
+788
+01:19:35,240 --> 01:19:40,120
+في كل نوع من الـ Beta-thalassemia هذا بيحطوا Beta
+
+789
+01:19:40,120 --> 01:19:46,140
+-thalassemia Plus أو Beta Zero Beta Zero بيكون
+
+790
+01:19:46,140 --> 01:19:52,860
+more يعني Severe in the manifestation بيكون درجة
+
+791
+01:19:52,860 --> 01:19:57,680
+الأنيميا، درجة الخلل شديد كثيرفبنكتبوا لكم Beta
+
+792
+01:19:57,680 --> 01:20:05,920
+Plus بيكون أخفر وفي مجال أحسن يعني المريض بيعيش
+
+793
+01:20:05,920 --> 01:20:09,600
+أحسن يعني أو بيكون الـHemoglobin تبعه أحسن أو
+
+794
+01:20:09,600 --> 01:20:15,140
+بعضها almost يعني almost reaching normal، ناشي؟
+
+795
+01:20:15,140 --> 01:20:21,040
+فهدولة يعني بالنسبة للـBeta-thalassemia ممكن ييجي
+
+796
+01:20:21,040 --> 01:20:25,420
+مع الـsickle cell ممكن واحد مصاب بالـCS Hemoglobin
+
+797
+01:20:25,840 --> 01:20:31,660
+والثانية فيها ثلاثينية بشكل اللي هو يؤثر على الـ
+
+798
+01:20:31,660 --> 01:20:35,700
+Level of the gene expression أو البروتين اللي
+
+799
+01:20:35,700 --> 01:20:45,520
+موجود هاي أمثلة عشان الـ Multiple للـ Beta
+
+800
+01:20:45,520 --> 01:20:51,770
+-Thalassinبالنسبة للـ Gram shift نونسينس كودون
+
+801
+01:20:51,770 --> 01:20:56,990
+Unstable Globulin Small Deletion RNA كذا يعني
+
+802
+01:20:56,990 --> 01:21:02,350
+تأثيرات الـ Mutations اللي بتسوي Beta-thalassemia
+
+803
+01:21:02,350 --> 01:21:05,690
+الآن
+
+804
+01:21:05,690 --> 01:21:14,170
+تفاصيلها بدنا أشيها، ناشي؟ بالنسبة للـ Alpha
+
+805
+01:21:14,170 --> 01:21:14,970
+-thalassemia
+
+806
+01:21:17,530 --> 01:21:24,310
+اللي طبعاً حكينا هاي أسف هاي كمان للـ Beta هاي للـ
+
+807
+01:21:24,310 --> 01:21:31,550
+Beta هاي أنواع الـ Eta والـ G Gamma والـ A Gamma
+
+808
+01:21:31,550 --> 01:21:38,010
+وكده وبيحطوا كيف في كل population من الـ Humans في
+
+809
+01:21:38,010 --> 01:21:42,270
+إشي مختلف ليش؟
+
+810
+01:21:50,200 --> 01:22:03,800
+تواني هاي بقول بالنسبة لو افترضنا أنه
+
+811
+01:22:03,800 --> 01:22:14,060
+بقول بالنسبة لقضية المرتفعات لأ هاي الـ «سلايدات»
+
+812
+01:22:14,060 --> 01:22:15,600
+مش كاملة آسف
+
+813
+01:22:18,100 --> 01:22:24,000
+بالنسبة لقضية المرتفعات آخر slide أنا حاطه بس فيه
+
+814
+01:22:24,000 --> 01:22:29,480
+أشياء بعدين ممكن نحكيها ولمرة الجاية برجع بعيد
+
+815
+01:22:29,480 --> 01:22:39,740
+عليها من الأول بالنسبة لقضية أنه يعني يعني
+
+816
+01:22:39,740 --> 01:22:46,500
+محاولة تفسير ليش بعض الأمراض أكتر في بعض الـ
+
+817
+01:22:46,500 --> 01:22:54,990
+populationsفي بعض المجموعات البشرية، ليش؟ شو اسمه؟
+
+818
+01:22:54,990 --> 01:22:59,890
+وقد يكون جزء من الموضوع اللي هي قضية إنه إذا
+
+819
+01:22:59,890 --> 01:23:08,930
+البيئة فيها يعني إذا فيها مظهر معين فيها ميز معين
+
+820
+01:23:08,930 --> 01:23:18,110
+بتفضل أو بتنفر مجموعة معينةفاللي عنده S-Hemoglobin
+
+821
+01:23:18,110 --> 01:23:26,110
+بيحب أو بيقدر أو بتحمل يروح يعيش في المرتفعات راح
+
+822
+01:23:26,110 --> 01:23:32,950
+يقول لأ لأن المرتفعات الأكسيدين فيها أقل الـ21%
+
+823
+01:23:32,950 --> 01:23:36,530
+اللي بتعرفها هذه لنسبة الأكسيدين في الهواء على سطح
+
+824
+01:23:36,530 --> 01:23:42,130
+البحر كل ما تطلع فوق، ماشي، راح تلاقي نسبة
+
+825
+01:23:42,130 --> 01:23:46,980
+الأكسيدين أقلفاحتمالية إن واحد عنده SS hemoglobin
+
+826
+01:23:46,980 --> 01:23:52,960
+يصير عنده attack ويصير عنده crisis أكبر لما يرتفع
+
+827
+01:23:52,960 --> 01:23:58,340
+الواحد على سطح البحر فهي زي ما حكينا كجانب منفر
+
+828
+01:23:58,340 --> 01:24:02,780
+لهذا الميزة يعني على عكس بتعطيه disadvantage
+
+829
+01:24:02,780 --> 01:24:10,380
+بتعطيه ضغط يعني بـ بـ بـ يعني ما بتعطيهوش أفضلية
+
+830
+01:24:10,380 --> 01:24:17,040
+بتعطيهبارد يعني بيحب ينزل على الـ الـ الـ على الـ
+
+831
+01:24:17,040 --> 01:24:20,300
+sea level عشان نسبة الـ Oxygen أكتر وإذا نسبة الـ
+
+832
+01:24:20,300 --> 01:24:25,980
+Oxygen أكتر في الأغوار وفي مكان بـ low sea level
+
+833
+01:24:25,980 --> 01:24:31,700
+أكتر ممكن أنه يكون يحب يروح هناك لأنه بيشوف حاله
+
+834
+01:24:31,700 --> 01:24:37,340
+أحسن بيصيبوش نفس المرض في أي ناحية بالنسبة للـ
+
+835
+01:24:37,340 --> 01:24:43,990
+Alpha Thalassemiaالـ Thalassemia طبعاً يعني إلها
+
+836
+01:24:43,990 --> 01:24:50,150
+برضه عراض كثيرة بالذات يعني فيه slide بما إنه أنا
+
+837
+01:24:50,150 --> 01:24:56,250
+عندي أربعة copies من الـ أربعة copies من الـ Alpha
+
+838
+01:24:56,250 --> 01:25:04,930
+genes ماشي اللي هي Alpha 1 و Alpha 2 عندي أربعة
+
+839
+01:25:04,930 --> 01:25:11,660
+copies والأمر بكون deletionفممكن إنسان الأسان
+
+840
+01:25:11,660 --> 01:25:18,000
+الطبيعي عنده الأربع إذا واحد راح، بكون إش خفيف وما
+
+841
+01:25:18,000 --> 01:25:23,900
+بسويش إشي، بعملش مرض فمن يروح اتنين، بنسميه Alpha
+
+842
+01:25:23,900 --> 01:25:31,860
+Thalassemia Carrier إذا ثلاثة راحل وبظل one copy،
+
+843
+01:25:31,860 --> 01:25:38,840
+بكون يعني Perseveredوبكون الإنسان مصاب
+
+844
+01:25:38,840 --> 01:25:42,980
+بالـClassical Thalassemia الـAlpha اللي هي بتلاقي
+
+845
+01:25:42,980 --> 01:25:46,920
+Short Stature فيه Bossing of the Bones of the Face
+
+846
+01:25:46,920 --> 01:25:51,840
+فيه Hepatosplenomegaly فيه Anemia فيه Hemolysis
+
+847
+01:25:51,840 --> 01:25:57,900
+فيه Aplastic Anemia Tendency فيه مشاكل يعني كثيرة
+
+848
+01:25:57,900 --> 01:26:05,690
+بتصير نتيجة الإنسان اللي عنده Alpha Thalassemiaف…
+
+849
+01:26:05,690 --> 01:26:13,090
+وده أربعة راحوا هذه بيسموه parts hemoglobin
+
+850
+01:26:13,090 --> 01:26:19,090
+وبيكون بس من الـ Beta-chain أربعة Beta-chain برضه
+
+851
+01:26:19,090 --> 01:26:25,410
+severe وبيكون incompatible with life يعني ما بعيش
+
+852
+01:26:25,410 --> 01:26:31,110
+الجنين هذا وبيموت في بطن إما بيسموه Hydroxpetalus
+
+853
+01:26:31,540 --> 01:26:38,880
+وهيكون سبب من أسباب إنه الإنسان هذا بعيشش النقطة
+
+854
+01:26:38,880 --> 01:26:44,700
+الأخيرة، يعني مش غلط، اقرأوها في الكتاب بالذات
+
+855
+01:26:44,700 --> 01:26:50,260
+بالنسبة للـThalassemia يعني الإنسان إنه يطلع مصاب
+
+856
+01:26:50,260 --> 01:26:56,160
+بالـThalassemia مشكلة كبيرة كتير كتير كتير يعني
+
+857
+01:26:56,160 --> 01:27:03,820
+إنسان هويت طفل من الأولهو يتغلب ويغلب أهله ويعيشوا
+
+858
+01:27:03,820 --> 01:27:11,580
+في حياة طبيعية ويكون يعني عنده مشاكل كبيرة
+
+859
+01:27:11,580 --> 01:27:17,800
+الأنيميا، بنضطر نعطيهم دم لما نعطيهم دم، بيصير
+
+860
+01:27:17,800 --> 01:27:21,340
+عندهم Iron Overload بيقولهم الـHepatitis، بيقولهم
+
+861
+01:27:21,340 --> 01:27:26,000
+الـHIV، بيقولهم أمراض بيصير عندهم تكرار
+
+862
+01:27:26,000 --> 01:27:30,420
+الـHemoglobinأو Blood Transfusion بيصير عندهم
+
+863
+01:27:30,420 --> 01:27:37,240
+Immunization فبيصيروا كل مرة وبعدين بيصير أصعب
+
+864
+01:27:37,240 --> 01:27:41,560
+وأصعب تلاقيلهم الدم تبعهم فهي حياة معاناة وغير
+
+865
+01:27:41,560 --> 01:27:49,580
+طبيعية فالملاحظ بالنسبة للثلاثينية ماشي أنه فيه
+
+866
+01:27:49,580 --> 01:27:56,560
+إمكانية التشخيص قبل الأول شيء يعني كثير من الدول
+
+867
+01:27:56,560 --> 01:28:04,060
+وأنظمةبتحط اللي هو الفحص ما قبل الزواج فطبعاً أسهل
+
+868
+01:28:04,060 --> 01:28:07,440
+طريقة أو الطريقة المعتادة مثلا عندنا في الأردن
+
+869
+01:28:07,440 --> 01:28:10,540
+اللي هو بيعملوا الـ Complete Blood Count اللي هو
+
+870
+01:28:10,540 --> 01:28:15,440
+الـCBC بندور لأن حجم الخلايا اللي عندهم
+
+871
+01:28:15,440 --> 01:28:20,400
+Hemoglobinopathy بكون أصغر وضمن مؤشرات أخرى
+
+872
+01:28:20,400 --> 01:28:24,880
+فالـMicrocytosis Indication حتى لو الـHemoglobin
+
+873
+01:28:24,880 --> 01:28:29,650
+normal كlevelنتيجة إنه عدد الخلايا أكبر بس حجمه
+
+874
+01:28:29,650 --> 01:28:33,790
+أصغر حيث إنه بيظل الـ Hemoglobin كويس يعني بس
+
+875
+01:28:33,790 --> 01:28:37,830
+بيكون شويه واضح فبتدلل على إن هذا الإنسان Carrier
+
+876
+01:28:37,830 --> 01:28:41,130
+يعني
+
+877
+01:28:41,130 --> 01:28:45,990
+إحنا الآن من الأمور الروتينية لكل المقبلين على
+
+878
+01:28:45,990 --> 01:28:52,870
+الزواج إنهم الأثنين يفحصوا الزوج والزوجة العريس
+
+879
+01:28:52,870 --> 01:28:58,740
+والعروض وإذا الأثنين عندهم المشكلةبيسيروا يقولوله
+
+880
+01:28:58,740 --> 01:29:04,620
+مروحه لأ على دكتور نقش الموضوع يعني
+
+881
+01:29:04,620 --> 01:29:12,380
+لعساس أنه نحاول أنه نتدخّل قبل ما يعني ييجي الطفل
+
+882
+01:29:12,380 --> 01:29:18,680
+والإنسان هذا فإذا كانوا الأثنين حاملين طبعا إذا
+
+883
+01:29:18,680 --> 01:29:24,760
+إنسان مصابوالتزامر السيسر في الغالب بيكون very
+
+884
+01:29:24,760 --> 01:29:30,160
+severe وما بيعيشش، مابتجوزش، مابقدرش هو بعدين ينقل
+
+885
+01:29:30,160 --> 01:29:38,160
+يعني أما اللي لما نكونه إنسان career فكل ما أقدرنا
+
+886
+01:29:38,160 --> 01:29:44,420
+نمنع زواج الأثنين المصابين بيكون أفضل وأحسن، أثناء
+
+887
+01:29:44,420 --> 01:29:50,350
+اللي بيصير يعني وبعض المجتمعات والدول ممكنبتاخدوا
+
+888
+01:29:50,350 --> 01:29:56,150
+طريق تاني يعني إذا زي ما بيقولوا زواج مدبر يعني
+
+889
+01:29:56,150 --> 01:30:03,690
+عيلة و عيلة الإممايات والآباء اتفقوا لو فحصوا لقوا
+
+890
+01:30:03,690 --> 01:30:10,030
+إنه في عدم تطابق في الغالب لأ ما يعني بيفرقش
+
+891
+01:30:10,030 --> 01:30:14,950
+الجيزة هذه لسبب طبي وبلاش من هالجيزة هذه بالذات
+
+892
+01:30:14,950 --> 01:30:21,200
+يعني ممكن اختار فرض آخر ولا كدهأحياناً المشاكل إذا
+
+893
+01:30:21,200 --> 01:30:26,380
+والله إثنين حبوا بعض وبيلا بدهم يتجوزوا وشوما يكون
+
+894
+01:30:26,380 --> 01:30:31,180
+يكون وشوما كذا بتلاقي هنا بتلاقي فيه صعوبة أخرى
+
+895
+01:30:31,180 --> 01:30:35,080
+يعني اللي هي قضية إن في بعض المجتمعات وبعض الدول
+
+896
+01:30:35,080 --> 01:30:43,060
+بيصيروا يعملوا فحص للـThalassemia عند الحمل، في
+
+897
+01:30:43,060 --> 01:30:49,690
+أول الحمل عشان لو كان الجنين مصابماشي وهذه
+
+898
+01:30:49,690 --> 01:30:55,010
+احتمالية إذا اثنين Carriers ربع وإذا الإنسان يطلع
+
+899
+01:30:55,010 --> 01:30:58,970
+منهم Carrier كمان احتماليته نصف واحتمالية تطلع
+
+900
+01:30:58,970 --> 01:31:03,810
+Completely Normal إذا اتوا Carriers ربع فنتيجة
+
+901
+01:31:03,810 --> 01:31:09,710
+الاحتماليات هذه احتمالية أنه اللي هي الربع أنه
+
+902
+01:31:09,710 --> 01:31:17,570
+يكون الجنين مصاب ففي ناس بعرضوا قضية اللي هيالـ
+
+903
+01:31:17,570 --> 01:31:21,610
+Termination أو الـ Abortion اللي هو الإجهاد إذا
+
+904
+01:31:21,610 --> 01:31:27,370
+كان وفيه الآن يعني بالذات للثلاثيميا لأنه بيعتمد
+
+905
+01:31:27,370 --> 01:31:32,930
+على الـ hematopoietic stem cells و الـ cells تبعات
+
+906
+01:31:32,930 --> 01:31:37,390
+الـ hematopoiesis بيصيروا يعملوا شو بيقولوله يعني؟
+
+907
+01:31:37,390 --> 01:31:41,510
+stem cell transplantation بيحاولوا يغيروا من الـ
+
+908
+01:31:41,510 --> 01:31:47,750
+hemoglobinوفيه يعني إذا بتسمعوا تقنية جديدة في
+
+909
+01:31:47,750 --> 01:31:52,890
+العالم ليه؟ CRISPR-9 اللي هو عبارة عن بروتين بيقدر
+
+910
+01:31:52,890 --> 01:31:57,930
+الواحد إذا بيقدر يحدد وين الجين المصاب يدخل ويعدّه
+
+911
+01:31:57,930 --> 01:32:02,090
+فهي يعني الفكرة إن هاي الـ Hemoglobin Obesity
+
+912
+01:32:02,090 --> 01:32:12,380
+بتعطي challenges للإنسانية والبشرية بحيث إنهيعني
+
+913
+01:32:12,380 --> 01:32:18,880
+في أمور كثيرة تباينات بين الدول في كيف يتعاملوا مع
+
+914
+01:32:18,880 --> 01:32:23,920
+الموضوع هذا في أسئلة؟
+
+915
+01:32:23,920 --> 01:32:27,500
+أتأخرنا
+
+916
+01:32:27,500 --> 01:32:33,580
+في البداية، أتأخرنا شويه بالنهاية وإذا في أسئلة،
+
+917
+01:32:33,580 --> 01:32:40,040
+أيوة سعادة إسألي
+
+918
+01:32:41,680 --> 01:32:46,820
+كان عندي ميوت يا دكتور، بدي أرجع للـ… للـsickle
+
+919
+01:32:46,820 --> 01:32:50,580
+-cell-anemia إن الـmutation تحول لـGlutamine
+
+920
+01:32:50,580 --> 01:32:56,360
+لـValine، تمام؟ ‏- أجل ‏- والـGlutamine تشارج
+
+921
+01:32:56,360 --> 01:33:00,180
+وValine Uncharged لما يصير عندي Uncharged، إيش
+
+922
+01:33:00,180 --> 01:33:03,380
+الفكرة اللي بدها تصير؟ اللي تخلّي الديوكسي والأخبط
+
+923
+01:33:03,380 --> 01:33:08,680
+هي؟ يعني من الأساس، أساس الفكرة ‏- حكيتلك إيها ‏-
+
+924
+01:33:08,680 --> 01:33:13,630
+انت قطع شوية الفترة ‏- أتنالك، أتنالكالـ Glutamine
+
+925
+01:33:13,630 --> 01:33:20,470
+Hydrophilic يعني بيحب الميه ‏- أه، لأنه تشارج ‏-
+
+926
+01:33:20,470 --> 01:33:25,230
+أه، و الثاني Hydrophobic يعني بيحبش الميه تتخبأ من
+
+927
+01:33:25,230 --> 01:33:30,550
+الميه فهذا المكان اللي .. اللي محل ستة هذا سطحي
+
+928
+01:33:30,550 --> 01:33:34,990
+يعني على السطح لما نكون يعني هيك الـ Theory أو هيك
+
+929
+01:33:34,990 --> 01:33:39,710
+التواقع لما نكون الـ Valine هو اللي موجود على
+
+930
+01:33:39,710 --> 01:33:45,130
+السطح و بالذات الـ Deoxyبحبش هاي الـ Status بحبش
+
+931
+01:33:45,130 --> 01:33:51,190
+هذا الوضع فبيحاول كل تنتين ذالين يلسقن بعض عشان
+
+932
+01:33:51,190 --> 01:33:55,690
+يكبوا بعض مايكونوش التنتين على السطح يعني بيصير يـ
+
+933
+01:33:55,690 --> 01:34:01,270
+Clumping بيصير هيك يتجمع مع بعض أقراها
+
+934
+01:34:01,270 --> 01:34:07,010
+و حاولوا يفهميها يعني لأنه يعني زي ما أقول كرة
+
+935
+01:34:07,010 --> 01:34:13,150
+الأصل سطح حملس مثلاًفي جزء منها بيلزق خيتي اللي
+
+936
+01:34:13,150 --> 01:34:18,090
+راح يصير إنه إذا الجزء اللي ملزق على السطح والكورة
+
+937
+01:34:18,090 --> 01:34:22,910
+اللي جنبها عليها برضه أيش بيلزق على السطح الاثنتين
+
+938
+01:34:22,910 --> 01:34:32,610
+بيلزقوا بعض عشان يخبوا بعض هيك بدأت كونها أوي
+
+939
+01:34:32,610 --> 01:34:36,190
+حتى الآن تمام خلاص بحاول أرجعلها من الكتاب كمان
+
+940
+01:34:36,190 --> 01:34:38,990
+يعني و لو واندي أسئلة أكيد هبعتك اليوم يا دكتور
+
+941
+01:34:39,700 --> 01:34:45,240
+أهلا وسهلا، طيب، الله يعطيكم العافية ونشوفكم إن
+
+942
+01:34:45,240 --> 01:34:48,980
+شاء الله يومنا نرجع، في أسئلة ثانية؟ بضالي؟ آه،
+
+943
+01:34:48,980 --> 01:34:53,420
+آه، بضالي، سمحت يعني بقصة إنه اللي هو الـcarrier
+
+944
+01:34:53,420 --> 01:34:57,440
+للـthalassemia بأخر إشي لما حكينا microcyte لما
+
+945
+01:34:57,440 --> 01:35:00,200
+يكون عنده microcytosis بالخلايا حتى لو كان
+
+946
+01:35:00,200 --> 01:35:04,420
+الهيموجلبين كويس ممكن الـcarriers للـthalassemia
+
+947
+01:35:04,420 --> 01:35:07,540
+أو Alpha-thalassemia يكون عنده microcytosis هاي
+
+948
+01:35:08,050 --> 01:35:10,930
+ولا، لازم تكون عندهم الـMicrophibrosis يعني ممكن
+
+949
+01:35:10,930 --> 01:35:16,810
+تكون عندهم المويزة الـCarrier ولا المصاب؟ لأ،
+
+950
+01:35:16,810 --> 01:35:19,550
+الـCarrier بحكي عنه، بحكي عن الـCarrier
+
+951
+01:35:19,550 --> 01:35:26,290
+الـCarrier؟ آه، آه، يعني يتزق من الـإذا أنتم
+
+952
+01:35:26,290 --> 01:35:30,930
+سريريا ماخدتوش أشياء كتيرة الـCBC، الـComplete
+
+953
+01:35:30,930 --> 01:35:38,760
+Blood Count، ماشي؟لما واحد يصير عنده أنيميا أو فيه
+
+954
+01:35:38,760 --> 01:35:43,020
+مشكلة بالنسبة للدم أكتر الشعسبب اللي هو الـ Iron
+
+955
+01:35:43,020 --> 01:35:47,280
+Deficiency Anemia الـ Iron Deficiency Anemia بيكون
+
+956
+01:35:47,280 --> 01:35:52,280
+عنده Microcytosis وAnisocytosis
+
+957
+01:35:52,280 --> 01:35:58,960
+وطبعاً Low Hemoglobin وشو اسمه؟ يعني Microcytic
+
+958
+01:35:58,960 --> 01:36:05,980
+Hypochromic Anemia اللي هويعني الـ MCHC إذا أنت
+
+959
+01:36:05,980 --> 01:36:10,300
+بتشوفي الـ CDC إذا شفتي نتيجة الـ CDC اللي بتطلع
+
+960
+01:36:10,300 --> 01:36:17,800
+من الجهاز فيها معلومات كثيرة الـ Hemoglobin و
+
+961
+01:36:17,800 --> 01:36:24,700
+بعدين الـ MCH اللي هو الـ Main Carboxylic Volume
+
+962
+01:36:24,700 --> 01:36:33,810
+MCD و MCH و MCHC فهي فيه مؤشراتإذا الـ… الـIron
+
+963
+01:36:33,810 --> 01:36:39,510
+Deficiency Anemia الفكرة تبعتها الخلايا بتكون عن
+
+964
+01:36:39,510 --> 01:36:44,670
+تصغر بيكون الإنسان بالأول طبيعي وفيه حجم الخلايا
+
+965
+01:36:44,670 --> 01:36:50,290
+قريب من الطبيعة وطبيعي ففيه تفاوت في حجم الخلايا
+
+966
+01:36:50,290 --> 01:36:54,950
+أما إذا كل الخلايا صغار بنفس الشكل بنفس الحجم
+
+967
+01:36:54,950 --> 01:37:01,340
+مافيش تفاوت بينهم الـRDW رح يكون Normalبس الـ MCV
+
+968
+01:37:01,340 --> 01:37:08,400
+Low عشان الـ Carrier حتى إنه إذا الحجم الخلية صغير
+
+969
+01:37:08,400 --> 01:37:13,420
+ويكون عنده Hemoglobin كويس بيكون عنده Increased
+
+970
+01:37:13,420 --> 01:37:20,500
+number of red blood cells، ماشي؟ فهذا بيتعود، فيه
+
+971
+01:37:20,500 --> 01:37:27,000
+تغيرات معينة إذا إنسان بلاقي مثلا كرات الدم الحمر
+
+972
+01:37:27,730 --> 01:37:32,490
+اللي عادةً مثلًا من 3.5 إلى 5 مليون per cubic
+
+973
+01:37:32,490 --> 01:37:39,890
+millimeter فلما نتسير حوالي 6، 6.5 والـ MCB low
+
+974
+01:37:39,890 --> 01:37:47,130
+والهيمoglobin 12، 13، 11، الجهات الواطي يعني أوطى
+
+975
+01:37:47,130 --> 01:37:52,350
+الطبيعي بقول شبه متأكد إن هذا تلاثيميا ألف
+
+976
+01:37:52,350 --> 01:37:57,940
+تلاثيميا carrier مش مصابالمصاب الـ Hemoglobin
+
+977
+01:37:57,940 --> 01:38:05,700
+بيكون 8، 5، 6، 7، Very Low Low أه بيكون Low فمن
+
+978
+01:38:05,700 --> 01:38:10,060
+الـCBC العادي فبقول
+
+979
+01:38:10,060 --> 01:38:14,640
+بالنسبة لفحص الـCBC العادي ممكن الإشتباه للـAlpha
+
+980
+01:38:14,640 --> 01:38:19,820
+Thalassemia Career State يكون الواحد شبه متأكد إذا
+
+981
+01:38:19,820 --> 01:38:25,690
+الـMCV Normal، لأ مافيش Alpha Thalassemiaطبعًا، دا
+
+982
+01:38:25,690 --> 01:38:29,130
+أكد أخر معلومة يا دكتور، ماعليش طولت علات الـBeta
+
+983
+01:38:29,130 --> 01:38:33,790
+-thalassemia مافيهاش deletion بشكل عام بس في عندي،
+
+984
+01:38:33,790 --> 01:38:39,150
+بس يعني عندي quantity abnormal بطرق
+
+985
+01:38:39,150 --> 01:38:43,590
+أخرى، بغير الـ… بطرق أخرى، بس بيبقى عندي الـAlpha
+
+986
+01:38:43,590 --> 01:38:48,840
+-thalassemia، فيها deletion ما اللي حكيت أنافي
+
+987
+01:38:48,840 --> 01:38:54,120
+أسلحة مش موجودة راح نعرضهم الأسبوع الجاي اللي هو
+
+988
+01:38:54,120 --> 01:38:59,920
+أنه ممكن يلاجي هم أصلا بيكونوا أربع كوبيس من Alpha
+
+989
+01:38:59,920 --> 01:39:04,840
+ممكن يلاجي واحدة رايحة تلاتة أو اثنين أو واحد أو
+
+990
+01:39:04,840 --> 01:39:10,420
+صفر بلافة في كل الاحتمالات واردة كل الاحتمالات
+
+991
+01:39:10,420 --> 01:39:13,780
+واردة الـSevere اللي هم لما يكون عندي تلاتة يعني
+
+992
+01:39:13,780 --> 01:39:15,980
+ممكن يكون رايح عندي تلاتة من Alpha أو أربع من
+
+993
+01:39:15,980 --> 01:39:21,890
+Alpha وما يكونش عندي Alpha خالصحتى أربعة يمكن أن
+
+994
+01:39:21,890 --> 01:39:26,730
+يكون عندي موت للـ fetus في مرحلة شديمية والسبب أنه
+
+995
+01:39:26,730 --> 01:39:31,430
+ماعندي Alpha chance Alpha chance، نعم، صحيح،
+
+996
+01:39:31,430 --> 01:39:34,690
+ماعجبك الله استمع، هيك المعلومات صارت واضحة، يعطيك
+
+997
+01:39:34,690 --> 01:39:40,270
+العافية يا دكتور، يعطيك
+
+998
+01:39:40,270 --> 01:39:45,530
+العافية يا دكتور، الله يسهل يا أمك، يالا السلام
+
+999
+01:39:45,530 --> 01:39:45,830
+عليك
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/A4ftaxBd5gA.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/A4ftaxBd5gA.srt
new file mode 100644
index 0000000000000000000000000000000000000000..ed9f9cc3690004e1b6e1e40e7fe55a027dc33bdb
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/A4ftaxBd5gA.srt
@@ -0,0 +1,3092 @@
+1
+00:00:00,000 --> 00:00:05,100
+فصول أو هن أربعة، يعني في فصلين قريبات من بعض
+
+2
+00:00:05,100 --> 00:00:12,600
+وإقصار، فممكن ناخدهم في فصل، وفي فصل عن الـ ethical
+
+3
+00:00:12,600 --> 00:00:17,960
+considerations، الجوانب الأخلاقية ممتاز، يعني كويس أن
+
+4
+00:00:17,960 --> 00:00:24,380
+الواحد يتناوله في هذا الجانب. فقداش بقينا للمساق؟
+
+5
+00:00:24,380 --> 00:00:31,760
+هو إحنا تقريباً حالياً في الأسبوع، أعتقد التاسع يعني
+
+6
+00:00:31,760 --> 00:00:36,060
+يتبقى حوالي أربع أسابيع، يعني على ... على يعني أقصى
+
+7
+00:00:36,060 --> 00:00:40,020
+تقضية أربع أسابيع، أو يعني إشي زيّك، يعني أنا كل
+
+8
+00:00:40,020 --> 00:00:43,900
+أسبوع بكون محاضرتين، يعني إذا قولنا ست ... ست يعني
+
+9
+00:00:43,900 --> 00:00:47,940
+بالمتوسط ست محاضرات، أو خمسة، يعني أنا ... أنا حابب
+
+10
+00:00:47,940 --> 00:00:51,720
+الصراحة أحد عشر، آه أنا في شباب بيقولوا إحنا الأسبوع
+
+11
+00:00:51,720 --> 00:00:57,120
+أحد عشر، خلاص تمام تقريباً، يعني تقريباً زي ما قلت ست
+
+12
+00:00:57,120 --> 00:01:00,420
+محاضرات تقريباً بالمعدل، هات ست محاضرات إن شاء الله
+
+13
+00:01:00,420 --> 00:01:08,420
+أنا حابب أني ... to overview كبلان، والـ ... والـ USMLE
+
+14
+00:01:08,420 --> 00:01:12,920
+والـ Medical Genetics، الـ References الثانية الـ
+
+15
+00:01:12,920 --> 00:01:18,260
+Summaries، والهذه الأشياء، يعني أنا بالأول ما حبيت
+
+16
+00:01:18,260 --> 00:01:26,090
+أن نستخدمهم، باعتبار أنه فيهم يعني شرح كويس
+
+17
+00:01:26,090 --> 00:01:31,050
+للمفاهيم، عبارة عن أسئلة، يعني بدك تكون أنت مرّ عليك
+
+18
+00:01:31,050 --> 00:01:37,990
+المفاهيم، وهذه بتكون تذكير فيها، يعني فإن شاء الله
+
+19
+00:01:37,990 --> 00:01:44,870
+إحنا اليوم راح نراجع الأسئلة، ويعني
+
+20
+00:01:44,870 --> 00:01:51,890
+حابب ده، فيه أنا بشكل عام الأسئلة
+
+21
+00:01:51,890 --> 00:01:57,210
+يعني كانت في كثير منها سهلة، يعني في كثير منها
+
+22
+00:01:57,210 --> 00:02:02,990
+difficult index كان مرتفع، تقريباً الكل، أو نسبة
+
+23
+00:02:02,990 --> 00:02:11,020
+عالية، 80، 90، 70% جابوها، وفي سؤالين، ثلاثة بس اللي
+
+24
+00:02:11,020 --> 00:02:18,380
+فيهم مشاكل، كان يعني واحد بس اللي تحت الـ 20% جاوبه
+
+25
+00:02:18,380 --> 00:02:28,020
+صح، فممكن إحنا نراجع الأسئلة، ويعني حابب إنه الـ
+
+26
+00:02:29,230 --> 00:02:34,630
+الطلاب هم اللي جابوا، أو على أقل، إذا حد عنده أي
+
+27
+00:02:34,630 --> 00:02:38,590
+استفسار، في بعضهم بدوا يودوا أسئلة كيف هيك، و ليش
+
+28
+00:02:38,590 --> 00:02:45,290
+هيك، وكده، إحنا ما بديش أقول تغيير، بقدر ما إنه
+
+29
+00:02:45,290 --> 00:02:52,590
+اتفقنا مع دارة الكلية، أنه مراجع زي الـ USMLE، يعني
+
+30
+00:02:52,590 --> 00:02:59,640
+هي تقريباً كل اللي أنا شرحته فيها، بس في جوانب، يعني
+
+31
+00:02:59,640 --> 00:03:05,620
+على قل "so far"، بالنسبة للامتحان الأول، فيه نقطتين
+
+32
+00:03:05,620 --> 00:03:10,180
+يعني هيك ببالي، أنه نعيد شرحهم بطريقة، أو يعني نركز
+
+33
+00:03:10,180 --> 00:03:16,160
+عليهم، لأن الواحد لازم يكون منتبه عليهم، فالآن
+
+34
+00:03:16,160 --> 00:03:23,940
+يعني بطلب من الشباب، الدكاترة والدكتورات، أنه يعني
+
+35
+00:03:23,940 --> 00:03:28,720
+بالذات كمان الـ MCQs، كأسئلة، يعني إحنا الغالبية
+
+36
+00:03:28,720 --> 00:03:35,200
+العظمة من الطب، والعلم، والمبادئ أخذناها، يعني تقريباً
+
+37
+00:03:35,200 --> 00:03:41,080
+المفروض الواحد عنده حصيلة جيدة، بيظل أنه بده يأخذ
+
+38
+00:03:41,080 --> 00:03:46,780
+حصيلة أخرى من الحالات السريرية، ويعني يفكر في
+
+39
+00:03:46,780 --> 00:03:52,120
+الموضوع من خلال الأمراض، يعني هيك القصد، فماشي
+
+40
+00:03:52,120 --> 00:03:58,710
+الحال، في أسئلة؟ إن شاء الله، يعني أنا يعني في إمكاني
+
+41
+00:03:58,710 --> 00:04:03,770
+أي حد بيقدر يعمل unmute للـ للحساب تبعه، ويتكلم مع
+
+42
+00:04:03,770 --> 00:04:09,450
+الدكتور بشكل عام مباشر، مافي مشكلة، مافي مشكلة، هبدأ
+
+43
+00:04:09,450 --> 00:04:19,390
+وسوي share screen، عشان بالنسبة لتشوف الأسئلة، و
+
+44
+00:04:23,540 --> 00:04:31,460
+انتبهت دكتور أحمد، أني أنا هتعطيك واحد وخمسين سؤال،
+
+45
+00:04:31,460 --> 00:04:36,360
+مش خمسين، في سؤال كان مشبوك اتنين ببعض، في مرات
+
+46
+00:04:36,360 --> 00:04:45,820
+واحد، يعني مهما يبدو الجهد، بيظل يعني بيظل في بعض
+
+47
+00:04:45,820 --> 00:04:51,040
+المرات هيك بنتبهش في أشياء، وبيحاول أنه يعني
+
+48
+00:04:51,040 --> 00:04:56,130
+يعملها مظبوط. طيب، لعنة خير، لعنة خير، المشكلة
+
+49
+00:04:56,130 --> 00:05:00,850
+الثانية بالنسبة
+
+50
+00:05:00,850 --> 00:05:08,450
+للـ الـ الـ file تبع الـ Excel تبع التقييم الأسئلة
+
+51
+00:05:08,450 --> 00:05:13,390
+عابه، أو مشكلته، مش بنفس الترتيب اللي أنا أعطيتكم إياه
+
+52
+00:05:13,390 --> 00:05:21,230
+يعني مرات بكون، يعني أنا ما عرفش السؤال الصعب، ولا
+
+53
+00:05:21,230 --> 00:05:31,080
+السهل. المهم، طيب إحنا المحاضرة اليوم قصيرة، إن شاء
+
+54
+00:05:31,080 --> 00:05:39,020
+الله، وإذا حد عنده أسئلة، هاي موجودة عندكم اللي
+
+55
+00:05:39,020 --> 00:05:47,400
+بتفرج أنا عليه، ماشي؟ الآن النقطة الأولى، All are
+
+56
+00:05:47,400 --> 00:05:51,200
+true about the origin of genetics understanding by
+
+57
+00:05:51,200 --> 00:05:52,100
+Mendel except
+
+58
+00:05:54,950 --> 00:06:01,310
+طبعاً، يعني دائماً من الأشياء المفهومة، أنه هو اشتغل
+
+59
+00:06:01,310 --> 00:06:05,470
+على الـ Bees، ولما
+
+60
+00:06:05,470 --> 00:06:11,510
+اشتغل، أعلن التجارب تبعته، ونشرها، بس ما حدا قبلها،
+
+61
+00:06:11,510 --> 00:06:15,690
+ما حدا طلى عليها، يمكن تلاتين سنة، بعدين كانوا
+
+62
+00:06:15,690 --> 00:06:20,710
+اكتشفوها، وكان هو أول إنسان بيتكلم عن صفات سائدة
+
+63
+00:06:20,710 --> 00:06:26,330
+ومتنحية، وكدا، هو درس تمان خواص في الـ ... في
+
+64
+00:06:26,330 --> 00:06:33,050
+الـ Pea plant، الطول، قصيرة ولا طويلة، اللون،  الجلقة
+
+65
+00:06:33,050 --> 00:06:37,570
+ولا smooth، تاكه، يعني الـSurface تبع حتة
+
+66
+00:06:37,570 --> 00:06:44,630
+الـ Pea plant، الـ ... الوردة تبعتها، طرفية من فوق، يعني
+
+67
+00:06:44,630 --> 00:06:50,150
+بنهاية النبات من فوق، ولا بتجند، يعني تمان خواص
+
+68
+00:06:50,700 --> 00:06:59,000
+والحظ، يعني نصيبه كان، الملاحظة تبعته، إنه بالنسبة
+
+69
+00:06:59,000 --> 00:07:02,860
+له، كل الـ traits دولة كانوا على different
+
+70
+00:07:02,860 --> 00:07:09,520
+chromosomes، فهذه الصدفة تبعته، يعني ظبطت معاه، إنه
+
+71
+00:07:09,520 --> 00:07:14,050
+كان عنده segregation of character، يعني إنه ما كان
+
+72
+00:07:14,050 --> 00:07:21,750
+فيه يعني ارتباط بين أي صفتين كان يدرسهم، أحياناً
+
+73
+00:07:21,750 --> 00:07:25,370
+إذا الـ "تو جين" كانت مع نفسها كروموزوم، ومرتبطة
+
+74
+00:07:25,370 --> 00:07:32,790
+"تو" كانت مرتبطة مع بعض، ويكون فيه اختلاف عن النسب
+
+75
+00:07:32,790 --> 00:07:38,530
+والأشياء اللي جابها، فهذه السؤال الأول، فيه أسئلة؟
+
+76
+00:07:39,350 --> 00:07:44,090
+إذا حد عنده أي سؤال، يعني أنا بشرح شو، فكرة السؤال
+
+77
+00:07:44,090 --> 00:07:49,950
+الأهم، شيء إن واحد ياخد الفكرة، بغض النظر، يعني بدي
+
+78
+00:07:49,950 --> 00:07:55,630
+أتعود على الـArticulation، يعني طريقة كتابة السؤال
+
+79
+00:07:55,630 --> 00:08:02,050
+لكل واحد، إيه طريقة، يعني كأستاذ، أو حتى في الـUSMLE
+
+80
+00:08:02,050 --> 00:08:06,600
+يعني من هيك الأشياء اللي لازم تنتبه لها، بالنسبة
+
+81
+00:08:06,600 --> 00:08:10,640
+للـ USMLE، مرات بيحطوا أسئلة، عشان يقيموا الأسئلة
+
+82
+00:08:10,640 --> 00:08:14,500
+يعني بيكونوا هم مش عارفين لسه، هل هذا السؤال واضح،
+
+83
+00:08:14,500 --> 00:08:21,060
+مش واضح، في مرات الإشكالية بتكون، إنه الصياغة فيها،
+
+84
+00:08:21,060 --> 00:08:26,580
+يعني أنا بالنسبة لفي سؤال عن، راح نيجي بعدين
+
+85
+00:08:26,580 --> 00:08:30,380
+بفجيكم إياه، الاختلاف عن المرة الأولى اللي عملتموها
+
+86
+00:08:30,380 --> 00:08:35,080
+الفاصلة، القامة، بجرد إن حطيتها، ولا ما حطيتها، عشان
+
+87
+00:08:35,080 --> 00:08:41,540
+أفرقت شوية، أو أوضحت أكثر السؤال
+
+88
+00:08:41,540 --> 00:08:48,300
+الثاني، All are true statements، الـGene's
+
+89
+00:08:48,300 --> 00:08:51,760
+definition، هو segments of the DNA that get
+
+90
+00:08:51,760 --> 00:08:55,940
+transcribed to RNA and proteins، الـGenome هو
+
+91
+00:08:55,940 --> 00:09:00,990
+الـAll genes of a cell، أو living organism، الـ Human
+
+92
+00:09:00,990 --> 00:09:04,590
+Genome Project، قعد حوالي عشر سنين، خلّصه قريباً
+
+93
+00:09:04,590 --> 00:09:10,750
+بالـ 2003، أول Whole Genome كان Drosophila، اللي هو
+
+94
+00:09:10,750 --> 00:09:16,190
+ذبابة الفاكهة، ذبابة الفاكهة، فيها أربع كروموزومات،
+
+95
+00:09:16,190 --> 00:09:20,410
+فاعتبروا إنها راح تكون أصغر واحدة، وتكون سهلة تنعمل،
+
+96
+00:09:20,410 --> 00:09:26,720
+فلما عملوا Sequence، كان دا الـDrosophila، الآن
+
+97
+00:09:26,720 --> 00:09:31,220
+الإمكانية عمل الـ Whole-Genome Sequencing، وكده
+
+98
+00:09:31,220 --> 00:09:38,100
+بتكون، لأن الـ Machinery، والتكنولوجيا، يعني الآن
+
+99
+00:09:38,100 --> 00:09:45,900
+ملايين المرات الـ ... الـMachines تريد الـSequence
+
+100
+00:09:45,900 --> 00:09:50,840
+DNA are much faster، much stronger، أحسن من تبعات
+
+101
+00:09:50,840 --> 00:09:59,570
+زمان، كانت أبطأ، وأقل كفاءة، ماشي، هي أسئلة، فهنا
+
+102
+00:09:59,570 --> 00:10:03,770
+الـ third genome was for Drosophila، هاي الخطأ
+
+103
+00:10:03,770 --> 00:10:08,730
+السؤال
+
+104
+00:10:08,730 --> 00:10:14,590
+التالت، all are areas used for genetics and
+
+105
+00:10:14,590 --> 00:10:18,590
+genomics؟ الـ cancer، الـ forensic medicine، الطب
+
+106
+00:10:18,590 --> 00:10:22,360
+الشرعي؟ Disease management and pathogenesis، الـ
+
+107
+00:10:22,360 --> 00:10:26,420
+Transplantation، كلهم بدهم الـ Genetics وGenomics
+
+108
+00:10:26,420 --> 00:10:32,040
+الـ Political Science، وما له دخل، مع أنه يعني مش
+
+109
+00:10:32,040 --> 00:10:38,060
+كتير غلط، إنه حتى بالنسبة للسياسة
+
+110
+00:10:38,060 --> 00:10:41,420
+الجينات
+
+111
+00:10:41,420 --> 00:10:46,850
+أحياناً تدخل في الـ يعني في العلوم السياسية،
+
+112
+00:10:46,850 --> 00:10:52,650
+التفريق العنصري، يعني
+
+113
+00:10:52,650 --> 00:10:57,530
+فيه مرات أشياء، أفكار، يعني القومية العربية مثلاً
+
+114
+00:10:57,530 --> 00:11:02,050
+يمكن تعتمد على جينات معينة، وكذا القوميات، وكذا،
+
+115
+00:11:02,050 --> 00:11:12,670
+يعني السؤال الرابع، الـDNA usually is loose، the DNA
+
+116
+00:11:12,670 --> 00:11:17,720
+becomes condensed، وDensely compacted، يعني في أكثر
+
+117
+00:11:17,720 --> 00:11:25,200
+شيء بيسمّيه كروموزوم، It's not a DNA probe،
+
+118
+00:11:25,200 --> 00:11:30,980
+الكروماتين هو segment من الكروموزوم، بيكون موجود في
+
+119
+00:11:30,980 --> 00:11:37,620
+حالة ما لم يتم استخدامه، اللايسوزوم لأ، هو vacuole
+
+120
+00:11:37,620 --> 00:11:43,720
+أو organelle in the cell، اللايسوزوم، والـ
+
+121
+00:11:43,720 --> 00:11:49,340
+Environmental factors ما لهم  بحاجة، آه يا محمود، إذا
+
+122
+00:11:49,340 --> 00:11:52,600
+في سؤال؟
+
+123
+00:11:52,600 --> 00:11:56,900
+في حد رفع إيده؟
+
+124
+00:11:56,900 --> 00:12:08,360
+تقريباً لأ، طيب، ليش هيك هذا؟ بس ثواني، خليني
+
+125
+00:12:13,390 --> 00:12:21,210
+مرة ثانية، حاول
+
+126
+00:12:21,210 --> 00:12:33,050
+أنزل تحت، طيب، لما
+
+127
+00:12:33,050 --> 00:12:37,850
+نكون، إحنا يعني لازم نفكر بالنسبة للـGenetic
+
+128
+00:12:37,850 --> 00:12:42,750
+Diseases into three types، main types، في الـ
+
+129
+00:12:42,750 --> 00:12:48,530
+Mendelian، هو اللي هو بيكون single gene disease due
+
+130
+00:12:48,530 --> 00:12:56,870
+to single gene، الـ other type بيكون many، يعني
+
+131
+00:12:56,870 --> 00:13:01,410
+whole segment of either the whole chromosome، أو
+
+132
+00:13:01,410 --> 00:13:04,630
+segment of the chromosome، بنسميه chromosomal
+
+133
+00:13:04,630 --> 00:13:09,450
+disease، ماشي، Multiple genes مع بعض، ويكون ده هو
+
+134
+00:13:09,450 --> 00:13:13,070
+الـChromosomal، يعني زي الـDown Syndrome، Turner،
+
+135
+00:13:13,490 --> 00:13:17,470
+Klinefelter، أشياء زي هيك، بدنا نسمّيها Chromosomes
+
+136
+00:13:17,470 --> 00:13:27,330
+الباقي Epigenetic، وPolygenic، دولة عبارة عن اللي هو
+
+137
+00:13:27,330 --> 00:13:31,070
+إحنا بنعتبرهم الـFair Type، ولّي هم الـCommon
+
+138
+00:13:31,070 --> 00:13:37,100
+اللي هي بتكون Multifactorial، يعني بالنسبة للـGenes،
+
+139
+00:13:37,100 --> 00:13:39,440
+الـGenetic Involvement، "هناك تجارب تجارب تجارب
+
+140
+00:13:39,440 --> 00:13:44,780
+تجارب"، Definite، Familial، منتشر أكثر بين
+
+141
+00:13:44,780 --> 00:13:50,640
+الـFamilies، بس بتكون مش جين واحد، ولا مجموعة جينات،
+
+142
+00:13:50,640 --> 00:13:55,060
+يعني مجموعة جينات متفرقة، بس مش في كروموزوم واحد، ولا
+
+143
+00:13:55,060 --> 00:13:58,560
+في segment of the chromosome، short arm، long arm
+
+144
+00:13:58,560 --> 00:14:03,560
+of a chromosome مثلاً، ولا كده، لأ، ما بتكون، فهي لما
+
+145
+00:14:03,560 --> 00:14:07,660
+تكون segment of many hundreds of thousands of
+
+146
+00:14:07,660 --> 00:14:15,100
+genes، بتكون في الـChromosome، الآن الـMicrobiome
+
+147
+00:14:15,100 --> 00:14:23,700
+يعني على كلمة genome، -ome، تعني اللي هي موضوع كل
+
+148
+00:14:23,700 --> 00:14:28,660
+الجينات تبعات الإنسان، أو تبعات الخلية، أي خلية
+
+149
+00:14:28,660 --> 00:14:35,480
+بيكون، يعني مثلًا نقول Cat Genome، يعني للبسة، أجي أبحث
+
+150
+00:14:35,480 --> 00:14:42,320
+الـ DNA كله، فالـ Genome هو وصف لكل الجينة، فبنفس
+
+151
+00:14:42,320 --> 00:14:48,300
+الطريقة، في طرق الآن نستخدم، بيسمّوه الـ Microbiome،
+
+152
+00:14:48,300 --> 00:14:57,050
+الـ Microbiome، اللي هو بندرسه بشكل محدد، أنواع الـ
+
+153
+00:14:57,050 --> 00:15:03,350
+Ribosomal RNA of the bacteria، وبندرس، يعني بناخد
+
+154
+00:15:03,350 --> 00:15:09,090
+مثلاً سامبل من الـ Gut، سامبل من الـ Skin، بكتيريا
+
+155
+00:15:09,090 --> 00:15:13,610
+أو Gut بكتيريا، أو Respiratory tract بكتيريا،
+
+156
+00:15:13,610 --> 00:15:20,950
+Mycosis، وبندرس كل أنواع الـ RNA، وRibosomal RNA
+
+157
+00:15:20,950 --> 00:15:25,640
+تبعتها، فبنعرف الـ Species تبعت البكتيريا، فالدراسة
+
+158
+00:15:25,640 --> 00:15:31,200
+الكاملة لهذا الموضوع، اسمها "microbiome"، أحياناً الـ
+
+159
+00:15:31,200 --> 00:15:34,700
+"epigenetics"، اللي هي "regulation of the genetics"،
+
+160
+00:15:34,700 --> 00:15:39,740
+أي ما أنا ذكرته، "metabolome"، "metabolomics"، اللي
+
+161
+00:15:39,740 --> 00:15:49,820
+هو، أو "exposome"، هو برضه طرق دراسة، بشكل كامل، مجمل
+
+162
+00:15:49,820 --> 00:15:56,030
+العوامل المؤثرة على الإنسان، يعني مثلًا بالنسبة
+
+163
+00:15:56,030 --> 00:16:03,630
+لنّوعية غذائنا، شو من المكونات تبعته، هي بشكل مجمل، مش
+
+164
+00:16:03,630 --> 00:16:12,930
+بشكل فردي، وشكل موحّد، فالـMicrobiome، والـGenome،
+
+165
+00:16:12,930 --> 00:16:17,910
+والـExposome، لازم يعني المفاهيم اللي واحد يكون
+
+166
+00:16:17,910 --> 00:16:19,550
+عارفها، ضروري يفهمها،
+
+167
+00:16:22,810 --> 00:16:27,950
+سؤال السابع، الـ
+
+168
+00:16:27,950 --> 00:16:34,510
+Somatic cells، عكس الـ Gonads، 97% من الـ DNA هو الـ
+
+169
+00:16:34,510 --> 00:16:40,770
+Nuclear DNA، ويكون بالـ Nucleus، الـ 3% يكون في
+
+170
+00:16:40,770 --> 00:16:47,570
+الميتوكوندريا، الميتوكوندريا نفسها، بالنسبة للـ A
+
+171
+00:16:47,570 --> 00:16:51,410
+طبعاً موجودة في الـ Both males and females، أنه
+
+172
+00:16:51,410 --> 00:16:54,450
+ميتوكوندريا في كل خلية، ففي جزء منها الـ
+
+173
+00:16:54,450 --> 00:16:58,970
+mitochondrial chromosomes، وبتكون بتبتدئ لحوالي 3% من
+
+174
+00:16:58,970 --> 00:17:03,890
+الـ DNA، الـ
+
+223
+00:21:44,710 --> 00:21:49,710
+polygenetic، هكذا المقصود؟ segment لما نقول عن
+
+224
+00:21:49,710 --> 00:21:55,200
+الـ DNA يعني اللي هو الـ Bands والـ  والـ
+
+225
+00:21:55,200 --> 00:22:00,540
+Chromosome نفسه، الـ Big Arm والـ Short Arm، هذان
+
+226
+00:22:00,540 --> 00:22:04,160
+بيكون فيهما Hundreds of Genes على الأقل أو Thousand
+
+227
+00:22:04,160 --> 00:22:08,140
+ماشي، فهذان Chromosomal، يعني الـ Chromosome هو
+
+228
+00:22:08,140 --> 00:22:12,920
+segment من الـ DNA، إنه 64 Chromosome، 46
+
+229
+00:22:12,920 --> 00:22:19,020
+Chromosome، ويكون فيه مشكلة في واحد منهما، فلما يكون
+
+230
+00:22:19,020 --> 00:22:23,540
+كل الـ Chromosome، الـ Chromosome من 1 إلى 22 والـ
+
+231
+00:22:23,540 --> 00:22:28,740
+X والـ Y، فيصبح فيهما مشكلة، هذه تُسمى Chromosomal
+
+232
+00:22:28,740 --> 00:22:36,980
+القريب منه، مثلاً، في سؤال سيأتينا، مريضة عندها، ما
+
+233
+00:22:36,980 --> 00:22:42,620
+اسمه؟ عندها، بتخلف الناس عندهم Down، وصار عندها
+
+234
+00:22:42,620 --> 00:22:47,870
+Trisomy 21، إنه Translocation من الـ Short-arm تبع
+
+235
+00:22:47,870 --> 00:22:51,390
+الـ، ما هو فيه بعض الـ Short-arm، ما فيه
+
+236
+00:22:51,390 --> 00:22:54,430
+كروموزومات كثيرة، يعني هي قطعة من الـ chromosome
+
+237
+00:22:54,430 --> 00:22:59,890
+يقول long أو short-arm، زايدة، ناقصة، متغيرة، هكذا
+
+238
+00:22:59,890 --> 00:23:06,770
+فلما يكون definitely، الـ C والـ D والـ E والـ A، ما
+
+239
+00:23:06,770 --> 00:23:12,050
+تُظبط، أقرب واحد للـ definition اللي هو إنه اللي فيه
+
+240
+00:23:12,050 --> 00:23:16,170
+كروموزوم، ماشي؟
+
+241
+00:23:22,680 --> 00:23:32,140
+سؤال ثمانية، ماشي، الإجابة
+
+242
+00:23:32,140 --> 00:23:38,380
+Which statement about DNA is correct، الـ backbone
+
+243
+00:23:38,380 --> 00:23:43,680
+هما الـ sugar والـ phosphate، الـ nitrogen base
+
+244
+00:23:43,680 --> 00:23:48,980
+اعتبرناها كالسلم، في درجات السلم، الـ nitrogen bases
+
+245
+00:23:49,990 --> 00:23:54,830
+الـ Sugar part، الـ DNA، الـ Deoxyribose،  ليس
+
+246
+00:23:54,830 --> 00:24:00,010
+Ribose، الـ phosphate group alternates with the
+
+247
+00:24:00,010 --> 00:24:02,850
+sugar one in the backbone، هي الإجابة الصحيحة
+
+248
+00:24:02,850 --> 00:24:07,090
+الأدينين والجوانين هما الـ Purines، التايمين
+
+249
+00:24:07,090 --> 00:24:13,290
+والسايتوزين هما البيريميدينات، عكستهم، فهذه هي المفروض
+
+250
+00:24:13,290 --> 00:24:13,990
+أنها واضحة
+
+251
+00:24:17,370 --> 00:24:23,590
+لما نستخدم X-Ray Crystallography، هذه الطريقة التي
+
+252
+00:24:23,590 --> 00:24:29,510
+هي... السؤال من نائل، بالنسبة لسؤال سبعة، نعم، الأولى
+
+253
+00:24:29,510 --> 00:24:36,290
+صحيحة، لماذا؟ انتظر، دعني أرى سؤال سبعة، آه، الأولى صحيحة
+
+254
+00:24:36,290 --> 00:24:41,710
+طبعاً، الناقل،
+
+255
+00:24:41,710 --> 00:24:46,500
+يعني الـ Mitochondrial DNA موجود لدى الـ Males والـ
+
+256
+00:24:46,500 --> 00:24:49,560
+Females، عندهم Mitochondria، أي خلية Male وFemale
+
+257
+00:24:49,560 --> 00:24:54,540
+فيها Mitochondria،  لكن الـ الـ الوراثة تبعته هي التي
+
+258
+00:24:54,540 --> 00:24:58,040
+فيها اختلاف، الوراثة تبعته بالنسبة لـ Mitochondrial
+
+259
+00:24:58,040 --> 00:25:04,680
+DNA، عن طريق الأم فقط، لأن الـ الـ الـ Sperm  لا  يحتوي
+
+260
+00:25:04,680 --> 00:25:09,240
+Mitochondrial،  لا يحتوي على Mitochondrial، ماشي،  الذي يشارك
+
+261
+00:25:09,240 --> 00:25:14,460
+يعني، الذي  ينقل الطاقة، في الـ Sperm لا يأخذه في منطقة الـ
+
+262
+00:25:14,460 --> 00:25:20,580
+Neck والرأس تبعه، الذي فيه الـ Tail، فالـ Tail تتحرك
+
+263
+00:25:20,580 --> 00:25:25,580
+لكي تُمكّن الـ Sperm من الحركة، لكن الـ Mitochondria التي
+
+264
+00:25:25,580 --> 00:25:29,120
+تحتاج طاقة موجودة في الـ Nucleus، لا تدخل في الـ
+
+265
+00:25:29,120 --> 00:25:35,660
+Fertilized egg، لما يأتي الـ Sperm ويخصب الـ، يعني
+
+266
+00:25:35,660 --> 00:25:41,500
+الميتوكندريا، الـ DNA  موجودة في الميتوكندريا
+
+267
+00:25:41,500 --> 00:25:48,070
+والـ DNA تبعها موجودة، بالنسبة للـ Inheritance
+
+268
+00:25:48,070 --> 00:25:52,770
+والإنتقال، فالسؤال
+
+269
+00:25:52,770 --> 00:25:59,310
+الإجابة A، هي جملة صحيحة وليست خاطئة، أما الـ D فهي
+
+270
+00:25:59,310 --> 00:26:05,310
+الخاطئة، واضح؟
+
+271
+00:26:05,310 --> 00:26:08,370
+أنا هنا، ما يعني، الـ male والـ female، يجب أن
+
+272
+00:26:08,370 --> 00:26:12,920
+يكون عندهما mitochondria، لكن الـ Mitochondrial
+
+273
+00:26:12,920 --> 00:26:21,900
+تبعته لا تنتقل للبنات وللأولاد إلا من الأم فقط، لما
+
+274
+00:26:21,900 --> 00:26:26,600
+نأتي لننظر باستخدام X-Ray Crystallography، وقد نرى
+
+275
+00:26:26,600 --> 00:26:31,620
+at a very، يعني، low level of resolution، الـ 2
+
+276
+00:26:31,620 --> 00:26:37,440
+نانومتر، نرى الـ Double Helix للـ DNA باستخدام الـ
+
+277
+00:26:37,440 --> 00:26:43,500
+X-Ray Crystallography، يجعل المادة التي تحتوي على الـ DNA
+
+278
+00:26:43,500 --> 00:26:50,720
+تأخذ شكل كريستال، ماشي، وبعدين they shine X-ray on
+
+279
+00:26:50,720 --> 00:26:55,720
+them، ويرون كيف الـ reflection  تبعها، ما
+
+280
+00:26:55,720 --> 00:27:00,300
+الانعكاس، ما الصورة التي ستظهر، يستنتجون منها كيف
+
+281
+00:27:00,300 --> 00:27:04,240
+الـ structure تبع هذه البلورة، طبعاً يجعلوها  يجب أن
+
+282
+00:27:04,240 --> 00:27:11,850
+تتبلور، تصبح على شكل بلورة، الـ average number of
+
+283
+00:27:11,850 --> 00:27:19,550
+genes per chromosome، تقريباً ألف، يعني هكذا بالمتوسط
+
+284
+00:27:19,550 --> 00:27:25,190
+في بعض الجينات very little، زي الـ Y-chromosome
+
+285
+00:27:25,190 --> 00:27:30,770
+ما فيه  فيه كثيراً، قصير وصغير، وبالنسبة مثلاً زي
+
+286
+00:27:30,770 --> 00:27:34,690
+chromosome 1، very large، يمكن فيه حوالي 2000 gene
+
+287
+00:27:34,690 --> 00:27:44,960
+فالـ average تقريباً ألف، يعني Recall، بالنسبة للـ Cell
+
+288
+00:27:44,960 --> 00:27:53,680
+Cycle أو Cell Division Cycle، نقسمها G0، لما يكون
+
+289
+00:27:53,680 --> 00:28:00,580
+الخلايا توقفت عن الإنقسام أو لا تريد أن تنقسم، ومراحل هذا عادة
+
+290
+00:28:00,580 --> 00:28:05,360
+الخلايا  المنقسمة، لما تنقسم تكون في مرحلة نسميها
+
+291
+00:28:05,360 --> 00:28:10,410
+G1، يعني، هي الخلية العادية، الخلية التي تكون
+
+292
+00:28:10,410 --> 00:28:16,490
+«between divisions»، وتؤدي وظيفتها، لما تقرر أنها
+
+293
+00:28:16,490 --> 00:28:22,470
+تنقسم، أو يأتيها أمر بأن تنقسم، تصبح الـ S-phase
+
+294
+00:28:22,470 --> 00:28:27,190
+التي هي هنا
+
+295
+00:28:27,190 --> 00:28:30,870
+«all are through stages of self-divisional cycle
+
+296
+00:28:30,870 --> 00:28:37,440
+except»، الـ S-phase، لا، هذه صحيحة، أنا ماذا وضعت؟ All
+
+297
+00:28:37,440 --> 00:28:41,880
+are true stages، الـ G0 التي هي when cells are not
+
+298
+00:28:41,880 --> 00:28:47,960
+dividing، صحيحة، الـ G1، الـ cells between divisions،
+
+299
+00:28:47,960 --> 00:28:55,740
+صحيحة، الـ S phase هي الـ
+
+300
+00:28:55,740 --> 00:28:59,080
+M phase when the cell division occurs، G2 phase
+
+301
+00:28:59,080 --> 00:29:03,200
+when cell prepares، صحيحة
+
+302
+00:29:04,880 --> 00:29:09,360
+دكتور، عفواً، هذا السؤال، كل إجاباته صحيحة، أظن هكذا
+
+303
+00:29:09,360 --> 00:29:14,920
+صحيح، أنا تَلَبَّسْتُ في الـ، يعني كل ما يظهر عن
+
+304
+00:29:14,920 --> 00:29:19,740
+الإجابات صحيح، نعم، ماشي، يعني، يعني يا دكتور هذا
+
+305
+00:29:19,740 --> 00:29:24,340
+هذا يُحذف، يعني ماذا يعني، ماشي، هذا يُحذف، هذا
+
+306
+00:29:24,340 --> 00:29:28,820
+نُحذفه، لا مشكلة، أه، دكتور أحمد؟ تمام، إن شاء الله
+
+307
+00:29:28,820 --> 00:29:34,660
+نحذف السؤال، ما، ما يُزعجك، آه، ماشي، الذي أنا
+
+308
+00:29:34,660 --> 00:30:02,180
+أقوله…………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………
+
+309
+00:30:02,540 --> 00:30:06,400
+دكتور، ينفع نجعله bonus بدلاً من حذفه، لأنه ضيَّعَ نُقطة
+
+310
+00:30:06,400 --> 00:30:08,720
+ونحن نتلبس في السؤال، يمكن نقضي ثلاث دقائق أو
+
+311
+00:30:08,720 --> 00:30:11,700
+أكثر ونحن نتحيّر في السؤال، كيف؟ أنا بالنسبة
+
+312
+00:30:11,700 --> 00:30:17,900
+لدكتور أحمد، أرى، دكتور أحمد، اسمعني، كم الـ
+
+313
+00:30:17,900 --> 00:30:21,680
+average وكم الـ standard deviation،  أُشيرُ إلى العلامة
+
+314
+00:30:21,680 --> 00:30:27,080
+والوسط العلامة للأسف، يعني من ناحية الوسط العلامة في
+
+315
+00:30:27,080 --> 00:30:32,840
+يعني، ثمانية طلاب تحت الخمسة عشر، أعلى علامة تسعة وعشرون
+
+316
+00:30:32,840 --> 00:30:37,300
+لم يحصل أحد على ثلاثين، تسعة
+
+317
+00:30:37,300 --> 00:30:41,440
+وعشرون من خمسين، تسعة وعشرون من ثلاثين، تسعة
+
+318
+00:30:41,440 --> 00:30:41,600
+وعشرون من ثلاثين، تسعة وعشرون من ثلاثين، تسعة
+
+319
+00:30:41,600 --> 00:30:43,360
+وعشرون من ثلاثين، تسعة وعشرون من ثلاثين، تسعة
+
+320
+00:30:43,360 --> 00:30:44,800
+وعشرون، ثلاثين، تسعة وعشرون، ثلاثين، تسعة وعشرون
+
+321
+00:30:44,800 --> 00:30:48,240
+ثلاثين، تسعة وعشرون، ثلاثين، تسعة وعشرون، ثلاثين
+
+322
+00:30:48,240 --> 00:30:51,420
+تسعة، وعشرون، ثلاثين، ثلاثين، ثلاثين، ثلاثين، ثلاثين
+
+323
+00:30:51,420 --> 00:30:52,340
+ثلاثين، ثلاثين، ثلاثين، ثلاثين، ثلاثين، ثلاثين، ثلاثين
+
+324
+00:30:52,340 --> 00:30:59,540
+ثلاثين، ثلاثين،  والله، تريد أن تجعله، اجعله الـ Average
+
+325
+00:30:59,540 --> 00:31:05,520
+إذاً، يعني، أنا أرى هكذا، يعني فيه good distribution
+
+326
+00:31:05,520 --> 00:31:10,440
+يعني،  معناته الأسئلة، أنا أرى أن الأسئلة كانت بشكل
+
+327
+00:31:10,440 --> 00:31:14,940
+عام مقبولة، فيه كثير علامات كاملة، كان فيها تقريباً
+
+328
+00:31:14,940 --> 00:31:18,580
+يعني فيه عدد أسئلة جيد، وفيه أسئلة كان فيها تلابُس
+
+329
+00:31:19,110 --> 00:31:26,170
+يعني يمكن هذا السؤال، الذي ربما تَلَبَّسَ الطلاب عليه كله
+
+330
+00:31:26,170 --> 00:31:30,550
+انظر لإدارة الكلية، أنا ليس لدي مشكلة، اجعله bonus، إذا
+
+331
+00:31:30,550 --> 00:31:37,650
+كنتَ تريد أن تعتبَرَه هكذا، أُعيد التصحيح واجعله، أو أحذفه وأُعيد
+
+332
+00:31:37,650 --> 00:31:41,190
+التصحيح مرة ثانية،  أيضاً يصبح bonus،
+
+333
+00:31:41,190 --> 00:31:47,270
+bonus أكثر، bonus أكثر، ماشي، ماشي، إن شاء الله
+
+334
+00:31:47,270 --> 00:31:50,750
+بالنسبة
+
+335
+00:31:50,750 --> 00:31:55,550
+للـ Stages، الـ Cell Division هذه، يعني،  بالتحديد لما
+
+336
+00:31:55,550 --> 00:32:01,130
+يرجع المرء  إلى ما يخص الـ USMLE، يجد  عليها أسئلة
+
+337
+00:32:01,130 --> 00:32:08,330
+ويجب على المرء أن يحفظها، وابنتي علمتني، تقول P-Math
+
+338
+00:32:08,330 --> 00:32:14,430
+ماشي؟ التي  إن على المرء أن يحفظ الـ Stages، ماشي؟
+
+339
+00:32:16,350 --> 00:32:22,270
+بالأول الـ Prophase، Metaphase، أول شيء Prophase،
+
+340
+00:32:22,270 --> 00:32:25,270
+ثم Pro-Metaphase، ثم Metaphase، Anaphase،
+
+341
+00:32:25,270 --> 00:32:32,690
+Telophase، ففي النهاية MAD، وفي البداية P، P، P، P، MAD
+
+342
+00:32:32,690 --> 00:32:37,630
+فالآن، which stage of cell division by mitosis
+
+343
+00:32:38,240 --> 00:32:43,140
+بالتالي، كان هناك مبنى نوكلياري، والـ Centromere لازال
+
+344
+00:32:43,140 --> 00:32:49,340
+هي الأولى، أول بداية، فتكون الـ Prophase، البقية
+
+345
+00:32:49,340 --> 00:32:53,840
+لا يكون فيها مبنى نوكلياري، الـ Centromere، الـ
+
+346
+00:32:53,840 --> 00:32:59,420
+Centrosome يكون موجوداً ويبدأ بالتكون، حتى يفصل
+
+347
+00:32:59,420 --> 00:33:06,400
+الكروموزومات عن بعضها، هذه
+
+348
+00:33:06,400 --> 00:33:07,320
+الـ Prophase
+
+349
+00:33:10,580 --> 00:33:14,700
+الآن، الـ «Chromosomes are arranged in the middle
+
+350
+00:33:14,700 --> 00:33:18,400
+with microtubules directing them to the central
+
+351
+00:33:18,400 --> 00:33:22,100
+zones»، التي تبدأ في حالة الـ «Metaphase»، لما
+
+352
+00:33:22,100 --> 00:33:26,960
+تترتب في هذا الشكل، بعدين تبدأ بالإنشداد على الجهتين
+
+353
+00:33:26,960 --> 00:33:31,020
+وينفصلوا، الـ «Anaphase»،  وبمجرد الإنتهاء، تتغير «Phase»
+
+354
+00:33:31,020 --> 00:33:33,360
+تعود الـ «Nuclear Membrane»،  تنفصل
+
+355
+00:33:36,720 --> 00:33:42,080
+الـ Usual Karyotyping و Binding of chromosomes، الـ
+
+356
+00:33:42,080 --> 00:33:49,860
+Right Stain، بالنسبة لنا نستخدمه مثل النيلسون للـ TD
+
+357
+00:33:49,860 --> 00:33:52,940
+الهيماتوكسيلينيوسين
+
+358
+00:33:52,940 --> 00:33:58,300
+للـ Stain، والـ Gram Stain للبكتيريا، ليس لنا دخل
+
+359
+00:33:58,300 --> 00:34:02,380
+الـ Right Stain للـ Red و Blood Cell والـ
+
+360
+00:34:02,380 --> 00:34:05,360
+Hematology، لكن الذي يستخدم الـ Giemsa Stain
+
+361
+00:34:09,510 --> 00:34:13,390
+بالنسبة لـ stage of cell division، الـ two gametes
+
+362
+00:34:13,390 --> 00:34:18,130
+في نهاية meiosis، تكون، هي الـ Anaphase 2
+
+363
+00:34:18,130 --> 00:34:23,090
+حتى
+
+364
+00:34:23,090 --> 00:34:27,530
+أنا، يعني، طبعاً  يجب أن نلاحظ، الـ meiosis فيه two
+
+365
+00:34:27,530 --> 00:34:33,500
+stages، Stage 1 وStage 2، ففي بعضها وضعت، يعني
+
+366
+00:34:33,500 --> 00:34:38,680
+يمكن لو كانت Telophase 2،  يمكن أكون أصحّ، أقرب
+
+367
+00:34:38,680 --> 00:34:44,440
+بين الـ Anaphase والـ Telophase، في النهاية، يجب أن تكون Anaphase
+
+368
+00:34:44,440 --> 00:34:49,160
+two، ليست الـ Metaphase ولا الـ Prometaphase، الـ Phase
+
+369
+00:34:49,160 --> 00:34:55,980
+one، لا يُقسم إلى two gametes لازال في الـ G2 phase
+
+370
+00:34:55,980 --> 00:35:01,600
+الـ DNA content is 4L normally،  اجعله لما بدأ ينقسم
+
+371
+00:35:01,600 --> 00:35:07,020
+بالـ G2، بالـ Mitosis
+
+372
+00:35:07,020 --> 00:35:13,680
+يبدأ  بالتكون، ما اسمه؟ 4M، يعني أصبح الـ S-Phase، وأصبح
+
+373
+00:35:13,680 --> 00:35:18,380
+الـ Duplication للـ DNA، لأن
+
+374
+00:35:18,380 --> 00:35:24,970
+all are true statements about the genome،  الكثيرة
+
+375
+00:35:24,970 --> 00:35:28,170
+العامة من الـ DNA في جسد الإنسان هي الـ Coding
+
+376
+00:35:28,170 --> 00:35:33,590
+للبروتينات المهمة، لا، 4، 5% فقط في الـ Human Genome
+
+377
+00:35:33,590 --> 00:35:38,790
+وهذا عكس كثير من الكائنات الحية الأخرى، يعني هذا
+
+378
+00:35:38,790 --> 00:35:43,390
+الجانب، يمكن المرء أن يطلع عليه، الكائنات
+
+379
+00:35:43,390 --> 00:35:51,660
+الأخرى، يعني الـ DNA أو المادة الوراثية، استُخدمت حتى
+
+380
+00:35:51,660 --> 00:35:57,880
+تستخدم بشكل كثيف لإنتاج البروتينات، والتي تكون
+
+381
+00:35:57,880 --> 00:36:03,300
+coding، الـ DNA، بينما الإنسان من الكائنات، يعني
+
+382
+00:36:03,300 --> 00:36:06,860
+الأشياء التي تكون فيها الـ non-coding هي
+
+383
+00:36:06,860 --> 00:36:13,800
+الـ majority، الـ Genes تُنسخ، ثم
+
+384
+00:36:13,800 --> 00:36:18,880
+يُتلاعب بها بالـ Splicing، لتصبح الـ Messenger RNA
+
+385
+00:36:20,150 --> 00:36:25,410
+باستخدام إزالة الـ Intron، صحيحة، الـ Messenger RNA
+
+386
+00:36:25,410 --> 00:36:32,910
+تُترجم إلى البروتينات، صحيحة، الترجمة تحصل في النواة
+
+387
+00:36:32,910 --> 00:36:37,390
+والترجمة في الريبوسومات، صحيحة، الـ Polypeptide Chains
+
+388
+00:36:37,390 --> 00:36:42,130
+تُعدَّل بعد ذلك بإزالة الجلد والميكانيزمات
+
+389
+00:36:42,130 --> 00:36:49,270
+الصحيحة، فهذه جميعها جمل صحيحة، ما عدا الأولى، الآن
+
+390
+00:36:51,110 --> 00:36:56,870
+كلها اختلافات حقيقية، إلا أن الفوسفات هي نفسها
+
+391
+00:36:56,870 --> 00:37:03,130
+الاختلاف في الـ DNA، السكر هو ديوكسي، ليس الريبوز
+
+392
+00:37:03,130 --> 00:37:08,550
+في الـ Uracil والتايمين، فيه اختلاف بينهما، الـ DNA
+
+393
+00:37:08,550 --> 00:37:14,2
+
+445
+00:41:59,990 --> 00:42:06,630
+«بروفيسور» بكون لسه موجود ماشي، اتطلع على الصورة وشوفها،
+
+446
+00:42:06,630 --> 00:42:07,490
+ماشي
+
+447
+00:42:11,980 --> 00:42:20,220
+بتكم ناخذ اللي هي الـ Human Genome خلّيني بس أفرج،
+
+448
+00:42:20,220 --> 00:42:26,880
+أطلّع على الصورة تبعتها هاي
+
+449
+00:42:26,880 --> 00:42:30,180
+وبعدين،
+
+450
+00:42:30,180 --> 00:42:34,640
+هاي، ثواني خلّيني أسوي لكم share بعد شوية بس،
+
+451
+00:42:34,640 --> 00:42:45,460
+ثواني على الـ… هايطيب، هاي هون الـ Genetic
+
+452
+00:42:45,460 --> 00:42:52,820
+Diversity نعم،
+
+453
+00:42:52,820 --> 00:43:00,980
+مش هذه هاي
+
+454
+00:43:00,980 --> 00:43:04,480
+طبعاً الـ Psychogenetics
+
+455
+00:43:15,530 --> 00:43:23,570
+وين راحت؟ مش شايف الصورة هسه لو أنا الـ human genome
+
+456
+00:43:55,820 --> 00:44:07,780
+أخر مرة أشوف هذه سبحان
+
+457
+00:44:07,780 --> 00:44:15,180
+الله كيف لما بدك إشي ما بتلاقيهوش، المهم ارجع للـ
+
+458
+00:44:15,180 --> 00:44:25,180
+بالنسبة للترتيب هذا، اتطلع على الصورة ويعني أنا
+
+459
+00:44:25,180 --> 00:44:33,020
+أظن الكلام واضح بالنسبة للـ… الكلام واضح بالنسبة
+
+460
+00:44:33,020 --> 00:44:39,700
+للـ… الـ Stage اللي هي يعني ركز على موضوع اللي هو
+
+461
+00:44:39,700 --> 00:44:44,400
+وجود الـ Cell Membrane، مش عارف عليه؟ آسف الـ
+
+462
+00:44:44,400 --> 00:44:47,650
+Nuclear Membrane، الـ Stage الوحيد اللي فيها Nuclear
+
+463
+00:44:47,650 --> 00:44:56,230
+Membrane هي الـ Prophase، بالنسبة للآن
+
+464
+00:44:56,230 --> 00:45:07,270
+السؤال على اللي هو أظن 1917 بالكوانين الآن
+
+465
+00:45:07,270 --> 00:45:16,360
+بس بنذبحكم على شغل بالنسبة لسؤال 19، ماشي يعني
+
+466
+00:45:16,360 --> 00:45:26,020
+بالنسبة لهنا، هاي الـShare بالنسبة
+
+467
+00:45:26,020 --> 00:45:29,860
+لترتيب الـ…
+
+468
+00:45:29,860 --> 00:45:36,460
+بالنسبة لترتيب الـ… إنه Amino Acids وTriplets كيف؟
+
+469
+00:45:36,460 --> 00:45:41,940
+وAnode coding for what؟ وكده فبدأ أطلب منكم
+
+470
+00:45:41,940 --> 00:45:52,860
+تتذكروا شغلة اللي هي… صراحة لقيتها في الـ USMLE
+
+471
+00:45:52,860 --> 00:46:00,960
+وغيره الآن، هذه الجدول اللي احنا شوفناها والـ First
+
+472
+00:46:00,960 --> 00:46:06,480
+Base هي الـ U وC وA وG، وهذه الـ Second Base اللي
+
+473
+00:46:06,480 --> 00:46:16,020
+هي الـ U وC وA وG، وهذه الـ Third Base هنا، فكل
+
+474
+00:46:16,020 --> 00:46:20,500
+ثلاثية هو أنا بعطيكم شو الـ Amino Acid تبعها
+
+475
+00:46:20,500 --> 00:46:27,800
+فالفينيل ألانين الـ UUU أو UUC مثلاً، يمكن يكون في
+
+476
+00:46:27,800 --> 00:46:34,900
+غيرهم، ماشي؟ الأشياء اللي لاحظته مركزين عليه ويله
+
+477
+00:46:34,900 --> 00:46:36,420
+تأثير في
+
+478
+00:46:38,900 --> 00:46:43,940
+يعني له تأثير في قضية بعض الحالات وبعض الأمراض
+
+479
+00:46:43,940 --> 00:46:50,580
+اللي حطينا اللي هو الـ «UAA»
+
+480
+00:46:50,580 --> 00:46:55,020
+و «UAG»، أنا ماكنتش حافظهم أو عمري ما حفظتهم أيه، بس
+
+481
+00:46:55,020 --> 00:47:00,900
+مش غلط الواحد يتذكر «UAA» أو «UAG»، هاي الـ «Stop
+
+482
+00:47:00,900 --> 00:47:10,770
+Codon» و «UGA»، هاي تلاتة ماشية دولة ثلاثة sequences
+
+483
+00:47:10,770 --> 00:47:19,470
+بتاعني stop، ماشي، فهدولة لما ييجيوكم مش عارف كيف
+
+484
+00:47:19,470 --> 00:47:28,050
+الواحد يحفظها UAA UGA UAG، يعني هدولة أولها U
+
+485
+00:47:28,050 --> 00:47:34,450
+وآخرها G وA، هدولة بمعنى stop، لما يحكوا لك ويديبوا
+
+486
+00:47:34,450 --> 00:47:42,610
+لك قصة وفيه سؤال جبته إنه فيه بالأخير خلل فيه إنه
+
+487
+00:47:42,610 --> 00:47:47,130
+صار إشي بدل إشي بحيث إنه اتكونت واحدة من هدولة
+
+488
+00:47:47,130 --> 00:47:55,090
+التلاتة بتخلي إنه يصير عند الحالة بيصير يعني بيصير
+
+489
+00:47:55,090 --> 00:47:58,510
+stop
+
+490
+00:47:58,510 --> 00:48:04,540
+reading of the بروتين أو التكوين للبروتين بيوقف
+
+491
+00:48:04,540 --> 00:48:12,880
+في مرحلة مش طبيعية، فهي ناحية مهمة، بس خلّيني أشوف
+
+492
+00:48:12,880 --> 00:48:25,200
+وين راحت هذه الصورة؟ فالآن
+
+493
+00:48:25,200 --> 00:48:30,970
+بالنسبة للسؤال اللي سألوا زميلكم، يعني احنا المهم
+
+494
+00:48:30,970 --> 00:48:37,730
+بدل واحد يتذكر فيه P-MAT أو P-MAT، فالـ Chromosome
+
+495
+00:48:37,730 --> 00:48:42,570
+الصورة هنا، الـ Prophase فيه Nuclear Membrane هي
+
+496
+00:48:42,570 --> 00:48:46,890
+الوحيد اللي فيها Nuclear Membrane لسه ما اتحطمش
+
+497
+00:48:46,890 --> 00:48:51,810
+بعد ما كثرت الـ DNA تبعها والـ Centromeres هي
+
+498
+00:48:51,810 --> 00:49:00,830
+الموجودة، فالسؤال الأتناش، شو اسمه؟ السؤال الأتناش
+
+499
+00:49:00,830 --> 00:49:09,370
+صحيح، ويعني هي الموجودة، ماشي الـ
+
+500
+00:49:09,370 --> 00:49:16,490
+Epigenetic Mechanisms، main point إنه they are
+
+501
+00:49:16,490 --> 00:49:21,710
+difficult to understand and difficult to study، يعني
+
+502
+00:49:21,710 --> 00:49:27,570
+الـ Mechanisms تبعتها للآن ما استقر العلم عليها
+
+503
+00:49:27,570 --> 00:49:36,190
+بشكل واضح، كامل، مبسط، سهل، كده، They are needed to
+
+504
+00:49:36,190 --> 00:49:40,390
+control which genes are activated in each type of
+
+505
+00:49:40,390 --> 00:49:47,310
+cell، صحيح، كل الجينات تبعت كل الخلايا في جسم
+
+506
+00:49:47,310 --> 00:49:52,190
+الإنسان زي بعض، اللي بيفرق خلية عن خلية إنه الجين
+
+507
+00:49:52,190 --> 00:49:56,230
+اللي اشتغل في هذه الخلية؟ كيف هذا الجين بيشتغل أو
+
+508
+00:49:56,230 --> 00:50:00,850
+مابيشتغلش؟ هذا الـ Epigenetic Mechanism، فهي صعبة
+
+509
+00:50:00,850 --> 00:50:07,150
+تدرس و تفهمها، الـ Genetic Imprinting أو الـ
+
+510
+00:50:07,150 --> 00:50:11,230
+Parental Imprinting، هذا والله للآن ماني فاهمه،
+
+511
+00:50:11,230 --> 00:50:15,530
+ماشي؟ بس هو Epigenetic Mechanism، يصير عندنا DNA
+
+512
+00:50:15,530 --> 00:50:20,280
+Methylation، Testosterone Variation وMethylation والـ
+
+513
+00:50:20,280 --> 00:50:25,200
+Genetic Imprinting، كلهم ميكانيزم للـ Epigenetic
+
+514
+00:50:25,200 --> 00:50:30,260
+Mechanism، اللي هما يعني مش في الـ Coding DNA، هدولة
+
+515
+00:50:30,260 --> 00:50:34,900
+في الـ Controlling DNA أو Controlling Mechanism
+
+516
+00:50:34,900 --> 00:50:42,060
+للـ Expression، ماشي، في أسئلة؟
+
+517
+00:50:42,060 --> 00:50:45,360
+الآن في موضوع اتكلمنا عنه اسمه الـ Allelic
+
+518
+00:50:45,360 --> 00:50:53,220
+Expression، اللي هو أنه الذي يتم إظهاره الأليل، وإذا
+
+519
+00:50:53,220 --> 00:50:57,400
+كان هناك إثنين أليل فهو يجب أن يتم إظهار الأليل
+
+520
+00:50:57,400 --> 00:51:03,720
+أحياناً تكون جينات معينة أن كلا الأليل تم إظهارهما
+
+521
+00:51:03,720 --> 00:51:09,300
+بشكل متساوي، صحيح، في أحيان بيحصل اسمه أشياء أليلية
+
+522
+00:51:09,300 --> 00:51:12,580
+في الانفجار، يعني يكون عنده أشياء مختلفة
+
+523
+00:51:25,250 --> 00:51:30,310
+الخيار الأول كأنه بيقول إن الـ expression خمسين
+
+524
+00:51:30,310 --> 00:51:34,850
+خمسين بالنِّسبة، الخيار الثاني صفر ومية
+
+525
+00:51:37,460 --> 00:51:41,260
+أحياناً ما بتكون في هالـ Two extremes، خمسين وخمسين
+
+526
+00:51:41,260 --> 00:51:46,200
+أو صفر ومية، مرات سبعين وثلاثين، ستين واربعين
+
+527
+00:51:46,200 --> 00:51:50,580
+مثلاً، فابدأ أسموه Unbalanced expression which
+
+528
+00:51:50,580 --> 00:51:54,920
+occurs in early embryogenesis، صحيحة، in females
+
+529
+00:51:54,920 --> 00:51:58,520
+الـ X chromosome inactivation randomly occurs
+
+530
+00:51:58,520 --> 00:52:03,640
+صحيح، وSomatic mutations which is a cause of
+
+531
+00:52:03,640 --> 00:52:10,320
+allelic expression variation، برضه صحيحة، بالنسبة للـ
+
+532
+00:52:10,320 --> 00:52:16,760
+Mutations، لما ندرس الـ Genome، الـ Most Common في
+
+533
+00:52:16,760 --> 00:52:23,520
+أي خلية تقريباً عن الـ Standard بيكون حوالي 5 إلى
+
+534
+00:52:23,520 --> 00:52:28,980
+10 مليون اللي هم Single Nucleotide Polymorphism
+
+535
+00:52:28,980 --> 00:52:34,040
+هدولة لما نسيروا ما بيقدّوا لهذا الشيء مرات كثيرة
+
+536
+00:52:34,040 --> 00:52:39,080
+خصوصاً إنه ممكن هذا يحدث في منطقة Non-coding، يعني
+
+537
+00:52:39,080 --> 00:52:45,180
+ما لهاش قيمة، يعني في بعضهم في عندنا Frame Shift
+
+538
+00:52:45,180 --> 00:52:50,000
+Type، Deletion Type، Inversion Type، Copy Number
+
+539
+00:52:50,000 --> 00:52:55,260
+Variation Type، هدولة Different Forms of Variation
+
+540
+00:52:55,260 --> 00:52:59,680
+بس أقوى إشي أكتر شي حدوثاً اللي هو Single
+
+541
+00:52:59,680 --> 00:53:06,960
+Nucleotide Polymorphism، الآن إذا صار عندي Deletion
+
+542
+00:53:06,960 --> 00:53:13,940
+أو Insertion، إذا ثلاثات أو مضاعفاتها ما لها قيمة
+
+543
+00:53:13,940 --> 00:53:18,400
+كبيرة ما بيأثر كثير على البروتين النهائي، بس لما
+
+544
+00:53:18,400 --> 00:53:21,700
+يصير عندي deletion أو insertion لـ one أو two
+
+545
+00:53:21,700 --> 00:53:28,960
+nucleotides، هذا هو المشكلة، إذا ثلاثة يعني بضيف
+
+546
+00:53:28,960 --> 00:53:35,220
+amino acid، ففي الغالب البروتين بتحمل وممكن يكون
+
+547
+00:53:35,220 --> 00:53:45,500
+يعني في منطقة مش مؤثرة، ماشي 6 و0 و3 ومضاعفاتها ما
+
+548
+00:53:45,500 --> 00:53:54,420
+في مشكلة، بس 1 و2 هي اللي فيها المشكلة، ماشي الحال؟
+
+549
+00:53:54,420 --> 00:54:01,500
+لما ندرس الـ Single Nucleotide Polymorphism
+
+550
+00:54:01,500 --> 00:54:08,020
+يعني خلّينا نتذكر كلمة… لما أريد أن أدرس كـ
+
+551
+00:54:08,020 --> 00:54:14,240
+Chromosome Anomaly، Turner-Klein Filter، كذا،
+
+552
+00:54:14,240 --> 00:54:19,920
+تعمل شيء يسمونه كـ Karyotype، لما أريد أن أدرس على
+
+553
+00:54:19,920 --> 00:54:24,420
+Single Nucleotide Polymorphism، لازم أعمل Sequencing
+
+554
+00:54:24,420 --> 00:54:30,360
+with PCR Reaction، ماشي، Polymerase Chain Reaction
+
+555
+00:54:30,360 --> 00:54:37,650
+فهذه الـ… الـ «سيجمان»
+
+556
+00:54:37,650 --> 00:54:45,330
+فيها غلط بالكتابة، ماشي، الـ sequencing of the DNA
+
+557
+00:54:45,330 --> 00:54:51,330
+الـ «BF» غلط، مش مفروض يكون هناك، ظهر بالطباعة
+
+558
+00:54:51,330 --> 00:54:58,270
+يعني الكاريوتيب ما بيظبط فيكي، بدرسش الكبير الـ
+
+559
+00:54:58,270 --> 00:55:05,000
+Fluorescent والـ Microsatellites
+
+560
+00:55:05,000 --> 00:55:12,700
+وحتى الـ Routine Banding، ماشي، هدولة مثلاً زي Dijard
+
+561
+00:55:12,700 --> 00:55:17,800
+Syndrome، زي يعني بيكون فيها segment كبير ما بيكون
+
+562
+00:55:17,800 --> 00:55:25,680
+تقدر تكشفني على Single Nucleotide Polymorphism، آه،
+
+563
+00:55:25,680 --> 00:55:31,910
+في سؤال؟ في سؤال مهم، في سؤال بيقول ليش ما عملنا
+
+564
+00:55:31,910 --> 00:55:36,670
+الـ FISH، الـ Fluorescent In Situ Hybridization، ال
+
+565
+00:55:36,670 --> 00:55:45,910
+… شوف سؤال 24، آه ما هو 24 خيار C، لأ احنا الـ FISH
+
+566
+00:55:45,910 --> 00:55:55,170
+أنا طريقته إني أنا بحط قطعة بتكون مثلاً عشرة، عشرين
+
+567
+00:55:55,170 --> 00:56:00,400
+ثلاثين، أربعين، ما بعرفش كده يعني بالضبط مية بالمية من
+
+568
+00:56:00,400 --> 00:56:07,300
+الـ DNA Nucleotides، ماشي، بحط ترتيب معين لحيث إنه
+
+569
+00:56:07,300 --> 00:56:12,460
+يعني شوف إذا تخيلنا، بطلب من الكل دائماً هيك يفكر
+
+570
+00:56:12,460 --> 00:56:18,000
+فيها، تتذكرها وكده، لما نتكلم عن Single Nucleotide
+
+571
+00:56:18,000 --> 00:56:23,820
+إذا تخيلنا البروتين قلنا مثال بالأول، البروتين هو
+
+572
+00:56:23,820 --> 00:56:33,680
+عبارة عن قصيدة شعر، ماشي، لما أنا بدي أدور على اختلاف
+
+573
+00:56:33,680 --> 00:56:40,560
+حرف، لازم أستخدم تقنية مختلفة، عامة من اللي بدي أدور
+
+574
+00:56:40,560 --> 00:56:45,920
+إذا فيه اختلاف بيت معين أو Segment، يعني لما
+
+575
+00:56:45,920 --> 00:56:51,060
+أنا بستخدم الـ FISH والـ Microsatellite
+
+576
+00:56:51,060 --> 00:56:56,540
+Array Test، هدولة والـ Karyotyping بدور على الكروموزوم
+
+577
+00:56:56,540 --> 00:57:02,510
+كله، ماشي؟ وما بيستحيل يفرجيني الـ Chromosome كله
+
+578
+00:57:02,510 --> 00:57:06,790
+الـ Single Nucleotide Polymorphism، الـ Fluorescent
+
+579
+00:57:06,790 --> 00:57:11,230
+In Situ Hybridization والـ Micro Satellite Array
+
+580
+00:57:11,230 --> 00:57:17,470
+بدك تحط الـ Segment of Interest، لازم تكون كبيرة
+
+581
+00:57:17,470 --> 00:57:24,150
+شوية حتى إنه يقدر يكون فيه تطابق بين قطعتين مع بعض
+
+582
+00:57:24,570 --> 00:57:28,730
+يعني زي كأنك بتعمل Google search، بتحف على شطر
+
+583
+00:57:28,730 --> 00:57:33,530
+القصيدة وبتشوف إني قصيدة قالوا فيها هالكلام مثلاً
+
+584
+00:57:33,530 --> 00:57:39,770
+وقوفا بها صاحبي عليا مطيهم، يقولوا لـ… تهلك أسن
+
+585
+00:57:39,770 --> 00:57:44,190
+وتجلد في… هدولة في على الأقل شاعرين في الجاهلية
+
+586
+00:57:44,190 --> 00:57:50,850
+قالوها، وقوفا بها صاحبي… بقول هذه القطعة هي المميزة
+
+587
+00:57:50,850 --> 00:57:57,330
+اللي أنا بدي إياها، بجيب برنامج كمبيوتر زي جوجل في
+
+588
+00:57:57,330 --> 00:58:02,970
+كل قصائد الشعر في الدنيا وبزدت عليها، وبأدور مين حكى
+
+589
+00:58:02,970 --> 00:58:08,910
+مثل هذا البيت، ماشي، هيك، هدولة FISH و Micro
+
+590
+00:58:08,910 --> 00:58:13,570
+satellite array، بس عشان أدقق إنه في حرف اختلف بين
+
+591
+00:58:13,570 --> 00:58:19,890
+حرف بين قصيدة وقصيدة تانية في مكان معين في شخص
+
+592
+00:58:19,890 --> 00:58:24,370
+معين أو كذا، بدي أعمل Polymerase Chain Reaction والـ
+
+593
+00:58:24,370 --> 00:58:27,410
+Sequencing، ما راح يديني إلا الـ Sequencing
+
+594
+00:58:27,410 --> 00:58:33,210
+ماشي، يعني الـ Sequencing بتعطيني براءة أحرف الـ
+
+595
+00:58:33,210 --> 00:58:39,370
+Nucleotides تبعات الـ… الـ DNA هذا عند هذا الإنسان
+
+596
+00:58:39,370 --> 00:58:45,290
+فلمّا نبدأ ندور على SNP، Staining الـ Nucleotides
+
+597
+00:58:45,290 --> 00:58:49,910
+Polymorphism اللي اسمها SNP، لازم أعمل Sequencing و
+
+598
+00:58:49,910 --> 00:58:50,370
+PCR
+
+599
+00:58:55,020 --> 00:59:01,240
+25 و26 من جدول straightforward، الـ Abbreviations
+
+600
+00:59:01,240 --> 00:59:05,440
+لازم الواحد يعرفها، الـ Marker Chromosome اللي هو الـ
+
+601
+00:59:05,440 --> 00:59:10,460
+MAR، يعني لما نستخدم الـ FISH والـ Microsatellite
+
+602
+00:59:10,460 --> 00:59:14,560
+الـ M هو الـ Maternal Chromosome، عكس الـ
+
+603
+00:59:14,560 --> 00:59:17,860
+Paternal Chromosome، يعني الـ Chromosome نسخة من
+
+604
+00:59:17,860 --> 00:59:24,680
+الأم مش من الأب، ماشي، الـ Maternal، فهذه واحدة، لما
+
+605
+00:59:24,680 --> 00:59:30,760
+يحطوا Abbreviation يكون فيها بالأخير Positive فيه
+
+606
+00:59:30,760 --> 00:59:34,480
+Gain of function، بعض الـ Diseases يا إما Loss أو
+
+607
+00:59:34,480 --> 00:59:38,460
+Gain of function، وفيه Translocation، الـ T والـ P
+
+608
+00:59:38,460 --> 00:59:41,900
+والـ Q والـ Short والـ Long، أعرف هدولة Standard
+
+609
+00:59:41,900 --> 00:59:47,240
+Abbreviation، يعني أنا بأعتقد عشان الواحد بعدين في
+
+610
+00:59:47,240 --> 00:59:51,880
+حياته لما يقرأ النتائج
+
+611
+00:59:54,460 --> 00:59:59,380
+يكون متذكر هدول الـ abbreviations مهمات، يعني أنا بـ
+
+612
+00:59:59,380 --> 01:00:05,440
+… كويس الواحد يتذكرها، الـ Commonest Mechanism of
+
+613
+01:00:05,440 --> 01:00:08,980
+Down Syndrome اللي هو associated with high
+
+614
+01:00:08,980 --> 01:00:13,300
+maternal age، اللي هو non-disjunction in meiosis
+
+615
+01:00:13,300 --> 01:00:19,440
+هذه الإجابة الصحيحة، في سؤال من دكتور بتقول في ممكن
+
+616
+01:00:19,440 --> 01:00:23,180
+توضيح أكثر لسؤال 21 اللي هو إيش؟
+
+617
+01:00:29,840 --> 01:00:35,700
+بس إنسان إنسان
+
+618
+01:00:35,700 --> 01:00:43,860
+عنده مثلاً Two chromosomes، ناخد مثلاً الـ Blood
+
+619
+01:00:43,860 --> 01:00:52,980
+Group AB-O system، ماشي، الآن اللي عنده Group AB عنده
+
+620
+01:00:52,980 --> 01:00:57,580
+Two chromosomes which are أو عنده Two alleles
+
+621
+01:00:5
+
+667
+01:05:38,070 --> 01:05:42,930
+الـCentromere يفشل، الـCentrosome يفشل، وكل الـTwo
+
+668
+01:05:42,930 --> 01:05:48,310
+copies يروح في جهة واحدة، فبالتالي الـSperm أو
+
+669
+01:05:48,310 --> 01:05:52,190
+الـEgg راح يكون فيه Two N مش One N، فلما تصير
+
+670
+01:05:52,190 --> 01:05:59,460
+التلقيح بيصير Three N أو ممكن يصير 4N، فهذه لما تحدث
+
+671
+01:05:59,460 --> 01:06:06,640
+هذا فاشل نهائيًا، لا يمكن يكمل، البقية تحدث، ممكن
+
+672
+01:06:06,640 --> 01:06:12,400
+يُوصل الـDown Syndrome، تحدث الـSuper Female XXX،
+
+673
+01:06:12,400 --> 01:06:17,120
+تحدث الـBalance Rearrangement في الأب نفسه أو
+
+674
+01:06:17,120 --> 01:06:23,150
+الأم، بيكون إذا حدثت مظبوط، والـXYY برضه بتحدث، هدولة
+
+675
+01:06:23,150 --> 01:06:31,290
+مش incompatible with lifestyle، ناشي؟ الـMost
+
+676
+01:06:31,290 --> 01:06:34,210
+Important Risk Factor for the occurrence of
+
+677
+01:06:34,210 --> 01:06:37,790
+Trisomy 21 اللي هو الـIncreasing Maternal Age، الـ
+
+678
+01:06:37,790 --> 01:06:41,450
+Smoking، الـMumps، الـExposure، الـRadiation،
+
+679
+01:06:41,450 --> 01:06:46,030
+جرمن نيزل، هدولة كلهم بيعملوا مشاكل تانية بس مش
+
+680
+01:06:46,030 --> 01:06:51,810
+الـDown Syndrome. Example of chromosomal segment
+
+681
+01:06:51,810 --> 01:06:59,670
+اللي هي الـshort arm الـP11، short arm of the
+
+682
+01:06:59,670 --> 01:07:06,110
+chromosome 22 أو 21، اللي هو DiGeorge Syndrome.
+
+683
+01:07:06,110 --> 01:07:12,750
+الأكندروبلازيا، Single mutation of chromosomal
+
+684
+01:07:12,750 --> 01:07:18,450
+dominant، الـBronchial asthma، بوليجينية، الهيموفيليا
+
+685
+01:07:18,450 --> 01:07:25,670
+A وB عبارة عن Single Gene، والـCystic Fibrosis مش
+
+686
+01:07:25,670 --> 01:07:30,650
+كرومزوم، سيجمند، كرومزوم كامل، بيبقى Problem، فده
+
+687
+01:07:30,650 --> 01:07:40,210
+الـ DiGeorge's Syndrome، الصحيح. فالـ31، What's
+
+688
+01:07:40,210 --> 01:07:44,630
+the main driving force for normal female sex
+
+689
+01:07:45,150 --> 01:07:48,950
+الـDevelopment هي الـDefault، وعدم وجود الـY
+
+690
+01:07:48,950 --> 01:07:56,410
+Chromosome اللي بيخلّي الإنسان يصير Female، إنه
+
+691
+01:07:56,410 --> 01:08:02,370
+مافيش Y-Chromosome أو مش شغال، و
+
+692
+01:08:02,370 --> 01:08:09,440
+الـInactive X-Chromosome اللي هو الـBarr Body، الـ
+
+693
+01:08:09,440 --> 01:08:14,260
+(أنومالي) الميل في
+
+694
+01:08:14,260 --> 01:08:22,680
+الـ(فينوتيب)، الـ(كلاينفلتر) اللي هو XYY، لما
+
+695
+01:08:22,680 --> 01:08:26,560
+يكون في عندي Double Lines بالنسبة للـPedigree،
+
+696
+01:08:26,560 --> 01:08:32,920
+اللي هو إن وجود Consanguinity لما نحط Double Lines،
+
+697
+01:08:32,920 --> 01:08:38,690
+ماشي، الـHorizontal Lines، الـProband بيحطوه هيك،
+
+698
+01:08:38,690 --> 01:08:45,290
+سهل، الـtwins identical و not identical، دو الـmale
+
+699
+01:08:45,290 --> 01:08:51,430
+و female، سيمبل، الدائرة و المربع و كده و هيك، main
+
+700
+01:08:51,430 --> 01:08:55,250
+second degree relative، الـparents و الـbrothers و
+
+701
+01:08:55,250 --> 01:08:59,810
+الـchildren، first degree، الـparents و الـ
+
+702
+01:08:59,810 --> 01:09:05,270
+brothers و الـchildren، الـspouse، الأصل بعيد الأصل،
+
+703
+01:09:06,420 --> 01:09:13,120
+الـSecond degree relative، الـGrandparents، الآن،
+
+704
+01:09:13,120 --> 01:09:18,920
+الـDisease transmitted on maternal line only، الـ
+
+705
+01:09:18,920 --> 01:09:22,060
+Females transmit the disease to their children،
+
+706
+01:09:22,060 --> 01:09:25,700
+both males and females، and affected males do not
+
+707
+01:09:25,700 --> 01:09:27,900
+transmit the disease، الـDefinition تبع
+
+708
+01:09:27,900 --> 01:09:35,770
+الميتوكوندريالية، حكينا السبب من قبل. هذا سؤال اللي
+
+709
+01:09:35,770 --> 01:09:41,270
+هو Single gene disease that affects males، المفروض
+
+710
+01:09:41,270 --> 01:09:45,930
+كان حطيت كومة، والـfemales are normal carriers،
+
+711
+01:09:45,930 --> 01:09:50,690
+اللي هو X-linked recessive، الناس قالوها جملة واحدة،
+
+712
+01:09:50,690 --> 01:09:56,270
+affects males and females، لأ طيب.
+
+713
+01:10:00,200 --> 01:10:04,320
+بالنسبة لسؤال 38، regarding the frequencies of
+
+714
+01:10:04,320 --> 01:10:07,120
+different types of genetic disorders in different
+
+715
+01:10:07,120 --> 01:10:16,820
+stages of life، All statements، نتذكر إنه الأول،
+
+716
+01:10:16,820 --> 01:10:23,480
+نسبة أو احتمالية حدوث سواء single gene أو
+
+717
+01:10:23,480 --> 01:10:30,440
+chromosomal disorders much higher، واللي بيظل عند
+
+718
+01:10:30,440 --> 01:10:35,360
+الإنسان لما يكون كبير بالعمر أو كان يكبر بالعمر أو
+
+719
+01:10:35,360 --> 01:10:37,880
+الـGeneral population بتكون Multifactorial
+
+720
+01:10:37,880 --> 01:10:42,460
+Diseases، فالـFrequencies of single gene disorders
+
+721
+01:10:42,460 --> 01:10:47,760
+are rarer، less frequent than genome، اللي هو
+
+722
+01:10:47,760 --> 01:10:52,300
+Multifactorial or Chromosomal disorders and all
+
+723
+01:10:52,300 --> 01:10:56,120
+stages، هاي غلط.
+
+724
+01:10:57,720 --> 01:11:04,640
+Multifactorial في الأول صحيح، هما لسه الـMost
+
+725
+01:11:04,640 --> 01:11:09,460
+Frequent، بس يعني إذا بتشوف الصورة مثلًا عشرة Single
+
+726
+01:11:09,460 --> 01:11:14,680
+Gene وخمسين Multifactorial، بعدها بيصير الـSingle
+
+727
+01:11:14,680 --> 01:11:19,880
+Gene مثلًا عشرين على الـGeneral Population،
+
+728
+01:11:19,880 --> 01:11:23,240
+والـMultifactorial 600، بصورة، ده بيصير عددهم كبير
+
+729
+01:11:23,240 --> 01:11:27,770
+كتير. الـSingle Gene and Genome and Chromosome، الـ
+
+730
+01:11:27,770 --> 01:11:31,070
+Single Gene and Genome and Chromosome، الـ
+
+731
+01:11:31,070 --> 01:11:35,090
+disorders are more frequent at birth، صحيح؟ إذا في
+
+732
+01:11:35,090 --> 01:11:40,370
+Single Gene وChromosomal disorders at birth، الـ
+
+733
+01:11:40,370 --> 01:11:43,070
+Multifactorial disorders increasing prevalence، و
+
+734
+01:11:43,070 --> 01:11:46,310
+decreasing age in general population، صحيح؟ وفي
+
+735
+01:11:46,310 --> 01:11:50,630
+حوالي 600 Multifactorial disease، صحيح؟
+
+736
+01:11:54,060 --> 01:11:58,600
+الـNormal Distribution تعريفه إنه الـ(مين) والـ
+
+737
+01:11:58,600 --> 01:12:02,820
+(مود) والـ(ميديان)، (المين) متوسط الحسابي، (المود)
+
+738
+01:12:02,820 --> 01:12:08,740
+اللي هو أكتر قراءة طالعة، (الميديان) هو اللي
+
+739
+01:12:08,740 --> 01:12:13,340
+بنرتبهم من الأول لأخر، بنحط المنتصف، المنصّف، الـ
+
+740
+01:12:13,340 --> 01:12:18,000
+(ميديان)، فدولة كلهم بيكونوا قريبين من بعض، فهذا الصحيح. الـ(مين)
+
+741
+01:12:18,000 --> 01:12:21,820
+plus minus one standard deviation، 67% من
+
+742
+01:12:21,820 --> 01:12:25,930
+الـpopulation، صحيح. اللي بتبدو مثلًا كـBell-shaped
+
+743
+01:12:25,930 --> 01:12:30,090
+with two tails، صحيح. الـmean plus two standard
+
+744
+01:12:30,090 --> 01:12:34,730
+deviations، 95% من المجتمع، صحيح. الـmany traits and
+
+745
+01:12:34,730 --> 01:12:38,610
+distributions follow
+
+746
+01:12:38,610 --> 01:12:41,550
+this distribution، الـnormal distribution، و it's
+
+747
+01:12:41,550 --> 01:12:47,490
+important for research، صحيحة جدًا. أقوى familial
+
+748
+01:12:47,490 --> 01:12:52,190
+aggregation، اللي هي الـrisk ratio، اللي هي الرمز
+
+749
+01:12:52,190 --> 01:12:56,780
+هذه، λs، في هذه الشكلة أيضًا، اللي هو الأولى للـ
+
+750
+01:12:56,780 --> 01:13:01,980
+Autism، 150، يعني شفت البقية كلهم فيهن بس هي أقوى
+
+751
+01:13:01,980 --> 01:13:06,840
+واحدة، درجتها أكبر بكثير يعني.
+
+752
+01:13:06,840 --> 01:13:14,960
+الـRecall مباشر، يعني إذا بنلاقي Familial
+
+753
+01:13:14,960 --> 01:13:21,750
+Aggregation of Disease، بعد مصادر الجينية، أي مصادر
+
+754
+01:13:21,750 --> 01:13:25,950
+قد تشرح الـAggregation، بدي يكونوا
+
+755
+01:13:25,950 --> 01:13:31,190
+shared environmental exposure، يعني والله المرض هذا
+
+756
+01:13:31,190 --> 01:13:36,730
+بيسببوا تسمم بالرصاص مثلًا، اللي هو إذا طفل
+
+757
+01:13:36,730 --> 01:13:40,870
+اتسمم بالرصاص في هذه العيلة، ممكن إخوانه، قرابته
+
+758
+01:13:40,870 --> 01:13:44,350
+اللي عايشين عندهم كانوا بيتعرضوا لنفس الرصاص، لأنهم
+
+759
+01:13:44,350 --> 01:13:48,670
+بيعيشوا بنفس البيئة، فـshared الـEnvironmental
+
+760
+01:13:48,670 --> 01:13:52,250
+Exposure هو الـOther Explanation of the Familial
+
+761
+01:13:52,250 --> 01:13:56,610
+Aggregation of Disease، الـGene Polymorphism،
+
+762
+01:13:56,610 --> 01:14:02,630
+وDevelopmental Of Mutation، وSame Family Name، يعني
+
+763
+01:14:02,630 --> 01:14:07,490
+كلها مش هي المسببة، أو التفسير الآخر للـFamilial
+
+764
+01:14:07,490 --> 01:14:11,010
+Aggregation، اللي هي Shared Environmental Exposure.
+
+765
+01:14:12,620 --> 01:14:17,600
+السؤال، هذا، الأسئلة اللي بعدين هي من المراجع
+
+766
+01:14:17,600 --> 01:14:27,980
+تبعتها، فيها يعني قصص، أو stories وكذا، وبنجيب
+
+767
+01:14:27,980 --> 01:14:34,600
+يعني أظن فيها يعني points مش غلط الواحد يتطلع عليها.
+
+768
+01:14:37,480 --> 01:14:44,840
+فيه researcher اللي الواحد بيقراها، بده يدرس الـ
+
+769
+01:14:44,840 --> 01:14:53,140
+Fast Ligand Interaction، وفي حالة في عائلة بيشوف إن
+
+770
+01:14:53,140 --> 01:14:59,680
+فيها مشكلة فيها، أيوة هدول فيه
+
+771
+01:14:59,680 --> 01:15:02,800
+أسئلة كأنه في حد بده
+
+772
+01:15:07,970 --> 01:15:16,090
+الآن الـ… الـبالنسبة لهذا السؤال، فيه بيحكي عن إن
+
+773
+01:15:16,090 --> 01:15:20,010
+الـFas-Fas-Ligand interaction مهم عشان الـ
+
+774
+01:15:20,010 --> 01:15:28,070
+control لـالـApoptosis، وفي أشياء كتيرة فالـ الآن
+
+775
+01:15:28,070 --> 01:15:34,450
+لقى في هذه الحالة إن الـFas-Protein هم كلهم الـ
+
+776
+01:15:34,450 --> 01:15:38,320
+Fas-Fas-Ligand هم عبارة عن self-service protein، فهو
+
+777
+01:15:38,320 --> 01:15:42,960
+بيشرح شو هي وبيحكي معلومات عنها، فلاحظ عند العائلة
+
+778
+01:15:42,960 --> 01:15:48,600
+هذه إن الـSoluble Fas Protein اللي لقاهم Shorter
+
+779
+01:15:48,600 --> 01:15:58,720
+وLacked Transmembrane Domain، ماشي؟ لما
+
+780
+01:15:58,720 --> 01:16:03,200
+شاف الـDNA Analysis of these cells revealed no
+
+781
+01:16:03,200 --> 01:16:10,100
+Fas gene mutation، يعني نفس الجين موجود بالثنتين، بس
+
+782
+01:16:10,100 --> 01:16:15,260
+الأصل يكون البروتين عبارة عن Trans-Membrane Domain،
+
+783
+01:16:15,260 --> 01:16:18,760
+وIntra-Cytoplasmic Membrane، والـExtra-Cytoplasmic،
+
+784
+01:16:18,760 --> 01:16:22,480
+يعني Extra-Cytoplasmic، والـTrans-Membrane، والـ
+
+785
+01:16:22,480 --> 01:16:27,820
+Intra-Cytoplasmic، تاني، هيك الأصل. فالـDNA متشابه،
+
+786
+01:16:27,820 --> 01:16:32,060
+فالـexplanation
+
+787
+01:16:33,640 --> 01:16:37,040
+اللي هو الـAlternative Splicing، الـAlternative
+
+788
+01:16:37,040 --> 01:16:43,040
+Splicing، اللي هو بيقطع الأشياء، الـDefective
+
+789
+01:16:43,040 --> 01:16:47,320
+polyadenylation، وDNA methylation، دولة تبعات الـ
+
+790
+01:16:47,320 --> 01:16:52,960
+polygenic أو الـEpigenetic Control، الـProtein
+
+791
+01:16:52,960 --> 01:16:58,180
+Lubrication والأشياء دي، كمال، هيتخلط مش هيك من
+
+792
+01:16:58,180 --> 01:17:05,390
+المرجع، وإذا كان واحد قاري وعرف يجيبها، أحسن. نعم يا
+
+793
+01:17:05,390 --> 01:17:08,750
+هديل، هذا
+
+794
+01:17:08,750 --> 01:17:12,090
+السؤال، يعني إحنا لما أنت شرحتينا إياه ماقلتلي ما
+
+795
+01:17:12,090 --> 01:17:14,530
+تركزوش كتير على الـalternative splicing والشغلات
+
+796
+01:17:14,530 --> 01:17:17,870
+هذه، لأنها مش كتير بتهمكم. هو صح كلامك إنه السؤال من
+
+797
+01:17:17,870 --> 01:17:23,430
+المرجع، بس إن إحنا عندنا الـأساس، اسمعي علي يا هديل،
+
+798
+01:17:23,430 --> 01:17:26,650
+ما بيجيبوني أسئلة، اسمعي علي يا هديل، غير لما
+
+799
+01:17:26,650 --> 01:17:29,350
+يكونوا إن أنا بدرسها من الكتاب، ما ركزتش عليها كتير،
+
+800
+01:17:29,350 --> 01:17:37,110
+أفهمي علي، لا لا، افهمي علي، يعني هي الفكرة، الفكرة
+
+801
+01:17:37,110 --> 01:17:42,730
+أنا لازم في الامتحانات أحط بعض الأسئلة الأصعب اللي
+
+802
+01:17:42,730 --> 01:17:49,370
+ما مش كل الناس يجاوبوها، ماشي؟ وبعدين يعني أنا الـ
+
+803
+01:17:49,370 --> 01:17:54,770
+trick في السؤال هذا، النقطة اللي بدي أخبيها منه هو
+
+804
+01:17:54,770 --> 01:18:00,190
+بصفّلك، يعني للأسف السؤال طويل، يعني ماشي، هو يمكن
+
+805
+01:18:00,190 --> 01:18:04,840
+أصعب من غيره، فالواحد يكون في بعض الأسئلة الصعبة مش غلط.
+
+806
+01:18:04,840 --> 01:18:14,000
+بالنسبة للأن زي هيك البروتين العادي، تفكري لأنك يا
+
+807
+01:18:14,000 --> 01:18:19,940
+دكتور بيكون طويل، فهمتي؟ والـDNA يعني هذا البروتين
+
+808
+01:18:19,940 --> 01:18:25,180
+قصير، والـDNA the same، يعني لمّا نقدر نفحص نفس
+
+809
+01:18:25,180 --> 01:18:29,900
+الـgene تبع الـDNA، على مستوى الـDNA مالكاش فيه
+
+810
+01:18:29,900 --> 01:18:36,100
+مشكلة، ففي الحالة هذه، المشكلة
+
+811
+01:18:36,100 --> 01:18:39,300
+أو الملاحظة راح تكون إنه في عندي الـAlternative
+
+812
+01:18:39,300 --> 01:18:42,480
+splicing، most likely، يعني by guessing you
+
+813
+01:18:42,480 --> 01:18:49,820
+might have got it، أما هو شوية سؤال أصعب و.. أه، أنا
+
+814
+01:18:49,820 --> 01:18:52,480
+يا دكتور، لعند إن الـDNA مافيش عليها مشاكل، معناها
+
+815
+01:18:52,480 --> 01:18:54,580
+إنو الشيء في الـepigenetic mechanisms، عشانك أنا
+
+816
+01:18:54,580 --> 01:18:57,760
+يوم حطيتها DNA methylation، ما ركزتش كتير على
+
+817
+01:18:57,760 --> 01:18:59,580
+الـalternative splicing، لأن إحنا أصلا مش
+
+818
+01:18:59,580 --> 01:19:00,340
+مابنعرفش على
+
+819
+01:19:00,340 --> 01:19:19,120
+الـ……………………………………………………………………………………………………………………………………………………………………………………
+
+820
+01:19:19,390 --> 01:19:23,490
+ماشي، الـEpigenetic… (كامل إنهيبش للإنزايم ممكن)
+
+821
+01:19:23,490 --> 01:19:28,930
+نعم، لأ لأ، الـ(ممكن تعمل إنهيبش للبروتين)، يعني
+
+822
+01:19:28,930 --> 01:19:33,750
+إيه؟ (ممكن تعمل إيه، دكتور؟) الـEpigenetic
+
+823
+01:19:33,750 --> 01:19:40,570
+Control هو بيقرر هل البروتين هذا هيطلع ولا لأ، بس
+
+824
+01:19:40,570 --> 01:19:44,750
+ما بيغيّر في البروتين، يعني هو بيغيّر كمية اللي طلع منه،
+
+825
+01:19:44,750 --> 01:19:49,200
+بس ما بيغيّر في شكل البروتين نفسه. فالقصص اللي
+
+826
+01:19:49,200 --> 01:19:53,980
+بيحكيلك إياها في الـFast Protein اللي طلعت هنا هي
+
+827
+01:19:53,980 --> 01:19:58,220
+على مسألة، إحنا حكينا، اللي بدل واحد يتذكر إنه أول
+
+828
+01:19:58,220 --> 01:20:02,400
+شيء الـDNA بيصير له Messenger RNA، أو للـRNA الـ
+
+829
+01:20:02,400 --> 01:20:06,820
+Primary، وفيه Introns وExtrons، وبيصير قص، أو لصق،
+
+830
+01:20:06,820 --> 01:20:09,440
+وبالذات لما نقول Trans-Membrane وIntra-
+
+831
+01:20:09,440 --> 01:20:13,180
+Cytoplasmic Domain، هذه بالـAlternative Splicing،
+
+832
+01:20:13,810 --> 01:20:18,510
+يعني حتى أنا بالنسبة لموضوع زي الـSecreted وCell
+
+833
+01:20:18,510 --> 01:20:23,850
+Surface Form of Immunoglobulins، بالمنعها، أمر على
+
+834
+01:20:23,850 --> 01:20:27,310
+مستوى الـRNA بالـAlternative Splicing، يعني مافيه
+
+835
+01:20:27,310 --> 01:20:30,590
+إشي بالمرحلة دي. على كل حال، يعني يا دكتور، حكيت
+
+836
+01:20:30,590 --> 01:20:34,690
+نفسي أول ما جيبت نفسي ريتها وانت بتشرحها، إيش هو؟
+
+837
+01:20:34,690 --> 01:20:39,510
+أصلًا ماجبتهاش، وماجبتها، الله يرضى عليكي، أنت أصلًا
+
+838
+01:20:39,510 --> 01:20:43,230
+المهم، جيبيها، ولما تيجي تدرسي الـUSMLE، جيبيها صح.
+
+839
+01:20:43,550 --> 01:20:49,610
+فبنجيلك زي هيك إنه فيه مشكلة إنه أكثر من Form اللي
+
+840
+01:20:49,610 --> 01:20:53,430
+صارت، يعني، أو اللي هي راح نجي بعدين أنا لأن ما كنت
+
+841
+01:20:53,430 --> 01:20:59,490
+شرحتها. سبب ثاني، إذا بيحكوا عنه اللي هو الـStop
+
+842
+01:20:59,490 --> 01:21:
+
+889
+01:24:26,390 --> 01:24:30,070
+دي اتحدث عنها الدكتور وربما ذكرها كتاب «تومسون»
+
+890
+01:24:30,070 --> 01:24:33,830
+فالفكرة أنه حتى الامتحان نفسه إحنا بنتعلم كمان منه
+
+891
+01:24:33,830 --> 01:24:37,250
+والأسئلة اللي بتيجي في الامتحان إحنا بناخد منها
+
+892
+01:24:37,250 --> 01:24:41,350
+معلومات فمش هنجف عند كل سؤال نقول هذا أجاب وهذا
+
+893
+01:24:41,350 --> 01:24:45,430
+ماجاناش، مظبوط إزاي؟ و يعني المادة بتمشي صح
+
+894
+01:24:45,430 --> 01:24:50,190
+خليني أقول الكلام اللي قصديها، الآن الأسئلة
+
+895
+01:24:50,190 --> 01:24:55,420
+الباقية كلها من مراجع من برة الآن، healthy couple
+
+896
+01:24:55,420 --> 01:25:06,440
+وعندهم autosomal recessive disease ماشي، وأُجِيء الـ
+
+897
+01:25:06,440 --> 01:25:10,180
+next child، what is the probability to be affected؟
+
+898
+01:25:10,180 --> 01:25:18,120
+الربع ماشي، standard لأنه هما من متقاربين، احتمال مش
+
+899
+01:25:18,120 --> 01:25:21,600
+Consanguinity، بس إثنينهم من Eastern Europe، في
+
+900
+01:25:21,600 --> 01:25:27,780
+أمريكا، وFirst Diseased Child، في الغالب بمعنى هما too
+
+901
+01:25:27,780 --> 01:25:33,340
+Healthy، معناته دول autosomal recessive وبالتالي
+
+902
+01:25:33,340 --> 01:25:41,620
+كل birth، الاحتمالية ربع. السؤال اللي بعده فيه شيء
+
+903
+01:25:41,620 --> 01:25:47,190
+يعني اللي هو بيسموه the Transcription Regulators
+
+904
+01:25:47,190 --> 01:25:53,730
+برضه هذا، يعني إن أنا ما عرضتوش كتير بس شفت إنه
+
+905
+01:25:53,730 --> 01:25:58,970
+مهم من ناحية الـ، يعني اقرأوا المرجعين دول يعني
+
+906
+01:25:58,970 --> 01:26:06,570
+على قُلّ، يعني بتكون فيها points اللي هو
+
+907
+01:26:06,570 --> 01:26:12,260
+the Transcription Regulators، H1 هستون برضه ما شرحتهاش
+
+908
+01:26:12,260 --> 01:26:19,440
+أبدًا، بس برضه يعني ترتيبها والـ، يعني بداية الـ
+
+909
+01:26:19,440 --> 01:26:29,640
+guessing شكل شو اسمه مفيد. 26 year old woman فيه
+
+910
+01:26:29,640 --> 01:26:37,330
+الآن high autosomal resistance story، الـstory مش
+
+911
+01:26:37,330 --> 01:26:41,770
+مهمة، يعني بالأخير واحد ياخد الفكرة، إذا اتزامل،
+
+912
+01:26:41,770 --> 01:26:47,070
+what is the probability that the unborn child will
+
+913
+01:26:47,070 --> 01:26:51,610
+inherit one or more؟ يعني هل هو heterozygous or
+
+914
+01:26:51,610 --> 01:26:55,310
+homozygous for the disease؟ راح يكون بما أن الـ
+
+915
+01:26:55,310 --> 01:26:58,810
+disease موجود في العائلة، والtwo parents are
+
+916
+01:26:58,810 --> 01:27:03,510
+carriers، فboth are obligate heterozygous، لازم
+
+917
+01:27:03,510 --> 01:27:10,370
+يكونوا heterozygous، فبكون 75%. المثال اللي حاطينه
+
+918
+01:27:10,370 --> 01:27:17,590
+هنا 47، الـpedigree لـX-linked recessive، ولد أو
+
+919
+01:27:17,590 --> 01:27:23,750
+شاب أو حد، وخاله مصابين. فالواحد وخاله لما بتشوفهم
+
+920
+01:27:23,750 --> 01:27:31,290
+دول X-linked recessive، الـhigh female جاي بـtwo
+
+921
+01:27:31,290 --> 01:27:35,900
+Down syndrome، فهي مش Non-disjunction، عمرها 26 سنة
+
+922
+01:27:35,900 --> 01:27:42,220
+يعني صغير بالعمر، فمش Non-disjunction. فالسبب إذا
+
+923
+01:27:42,220 --> 01:27:46,160
+بتصير هذه اللي هي Reciprocal Translocation مع
+
+924
+01:27:46,160 --> 01:27:51,660
+Chromosome 21، عادة بركب على Chromosome 14، فهي
+
+925
+01:27:51,660 --> 01:27:57,260
+عندها بتعطي أولادها two copies of Chromosome 22
+
+926
+01:27:57,260 --> 01:28:02,690
+و21، يعني، والأب بيعطي one copy، فبيصير Down syndrome
+
+927
+01:28:02,690 --> 01:28:10,150
+هاي زيادة. a man with hemophilia A، له X-linked
+
+928
+01:28:10,150 --> 01:28:16,950
+recessive، والزوجة واحدة heterozygous
+
+929
+01:28:16,950 --> 01:28:23,690
+carrier، فwhat proportion؟ الزلمة الـX تبعه مصاب
+
+930
+01:28:23,690 --> 01:28:28,650
+والـY طبيعي، أو الـY مالوش دخل. زوجة واحدة عندها طبيعي
+
+931
+01:28:28,650 --> 01:28:35,850
+ومصاب، فالبنات تبعتهم اللي
+
+932
+01:28:35,850 --> 01:28:41,930
+بيكون فيه نسبة خمسين بالمية بيكونوا مصابين، وخمسين
+
+933
+01:28:41,930 --> 01:28:46,810
+بالمية بيكونوا carriers، لازم يكون هيك. الـMarfan
+
+934
+01:28:46,810 --> 01:28:54,400
+Syndrome اللي هي Autosomal Dominant، وصار عندها بنت
+
+935
+01:28:54,400 --> 01:28:58,340
+في العائلة، ودورت في كل العائلة ما في حد عنده مثل هذا
+
+936
+01:28:58,340 --> 01:29:03,800
+الشيء، فهذه البنت أخدتها من الـNew Mutation، صارت
+
+937
+01:29:03,800 --> 01:29:12,020
+في أحد أبويها، اللي هي الـD، وخمسين اللي هو اسمه
+
+938
+01:29:12,020 --> 01:29:16,340
+Missense Mutation، اللي بعطيني هذا الشيء. أنا مضطر
+
+939
+01:29:16,340 --> 01:29:22,670
+عندي تدريس ثاني، إذا في أسئلة على الـGenetics هذه
+
+940
+01:29:22,670 --> 01:29:26,850
+كلها من المرجع، تطلعوا عليه وإن شاء الله المرات
+
+941
+01:29:26,850 --> 01:29:31,110
+الجاية برضه راح ناخد محاضرات، تبقى نسوي revision من
+
+942
+01:29:31,110 --> 01:29:35,550
+خلال أسئلة، وده في عندكم أسئلة عامة. ماشي، دكتور أحمد
+
+943
+01:29:35,550 --> 01:29:40,170
+أنا مضطر أطلع الآن، عشانك يا دكتور. مشكور جدًا على
+
+944
+01:29:40,170 --> 01:29:44,530
+يعني وقتك اللي… لا هذا واجب، مافي مشكلة إن شاء
+
+945
+01:29:44,530 --> 01:29:49,120
+الله نكون بنفيد. والـWhatsApp group، الـWhatsApp
+
+946
+01:29:49,120 --> 01:29:54,120
+Group، إذا حد بيختلّي سؤال عليه يعني، أخوة وأخوات
+
+947
+01:29:54,120 --> 01:30:02,320
+زملاء كتير بيبعتولي على الخاص، إلي لوحدي فيعني ما في
+
+948
+01:30:02,320 --> 01:30:08,660
+مشكلة، دايمًا بطلب إنه أبعته على التبعين الكل وأنا
+
+949
+01:30:08,660 --> 01:30:15,040
+يعني على طول، إذا بشوف أي سؤال برد عليه، وخلّينا نرد
+
+950
+01:30:15,040 --> 01:30:20,370
+من خلال الـGroup، ويخليها الواحد على الأسئلة، أما
+
+951
+01:30:20,370 --> 01:30:26,570
+إن داخل مش داخل، شرحته وما شرحتوش، هذا بنفع هذا
+
+952
+01:30:26,570 --> 01:30:32,010
+بنفعش، ما ندخلش في هذا السهل، يعني واجبي، وزي ما
+
+953
+01:30:32,010 --> 01:30:35,430
+اتفضل الدكتور أحمد، أنه من خلال الامتحان الواحد
+
+954
+01:30:35,430 --> 01:30:39,910
+كمان بيتعلم، يعني أنا ما بتذكرش الأسئلة اللي جوابتها
+
+955
+01:30:39,910 --> 01:30:43,950
+صح في المواد، بس اللي عالق في مخي أكتر من مرة
+
+956
+01:30:43,950 --> 01:30:48,610
+الأشياء اللي جوابتها غلط، وعارفة ليش جوابتها غلط.
+
+957
+01:30:48,610 --> 01:30:53,510
+خلوا أحد جزء من الدراسة، نشوف المراجع. أنا المراجع
+
+958
+01:30:53,510 --> 01:30:57,630
+اللي فيها أسئلة ما قدّرتش أبدأ فيها، من ناحية إنه
+
+959
+01:30:57,630 --> 01:31:02,770
+خلّينا ناخد شوية يعني خميرة من المعلومات العلمية
+
+960
+01:31:02,770 --> 01:31:08,880
+وأخيرًا يعني تفاصيل الأمراض، هاي إن شاء الله عندكم
+
+961
+01:31:08,880 --> 01:31:13,980
+طريق طويل تاخدوها بعدين. يالله يعطيكم العافية، يعطيك
+
+962
+01:31:13,980 --> 01:31:17,820
+ألف عافية، دكتور. الله يحييكم، نشوفكم يوم الأربعاء إن
+
+963
+01:31:17,820 --> 01:31:22,920
+شاء الله رب العالمين. يعطيكم العافية دكاترة، نشوفكم
+
+964
+01:31:22,920 --> 01:31:23,600
+إن شاء الله يوم الاثنين
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/A4ftaxBd5gA_postprocess.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/A4ftaxBd5gA_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..f59f1251722ebe7adadd1d56e13342af43745763
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/A4ftaxBd5gA_postprocess.srt
@@ -0,0 +1,3856 @@
+1
+00:00:00,000 --> 00:00:05,100
+فصول أو هن أربعة يعني في فصلين قريبات من بعض
+
+2
+00:00:05,100 --> 00:00:12,600
+وإقصار فممكن ناخدهم في فصل وفي فصل عن الـ ethical
+
+3
+00:00:12,600 --> 00:00:17,960
+considerations الجوانب الأخلاقي ممتاز يعني كويس أن
+
+4
+00:00:17,960 --> 00:00:24,380
+الواحد يتناوله في هذا الجانب فقداش بقينا للمساق؟
+
+5
+00:00:24,380 --> 00:00:31,760
+هو احنا تقريبا حاليا في الأسبوع أعتقدتاسع يعني
+
+6
+00:00:31,760 --> 00:00:36,060
+يتبقى حوالي أربع أسابيع يعني على .. على يعني أقصى
+
+7
+00:00:36,060 --> 00:00:40,020
+تقضية أربع أسابيع أو يعني إشي زييك يعني أنا كل
+
+8
+00:00:40,020 --> 00:00:43,900
+أسبوع بكون محاضرتين يعني إذا قولنا ست .. ست يعني
+
+9
+00:00:43,900 --> 00:00:47,940
+بالمتوسط ست محاضرات أو خمسة يعني انا .. انا حابب
+
+10
+00:00:47,940 --> 00:00:51,720
+الصراحة أحداشر اه انا في شباب بيقولوا احنا الأسبوع
+
+11
+00:00:51,720 --> 00:00:57,120
+أحداشر خلاص تمامتقريبًا، يعني تقريبًا زي ما قلت ست
+
+12
+00:00:57,120 --> 00:01:00,420
+محاضرات تقريبًا بالمعدل هات ست محاضرات إن شاء الله
+
+13
+00:01:00,420 --> 00:01:08,420
+أنا حابب أني … to overview كبلان والـ … والـ USMLE
+
+14
+00:01:08,420 --> 00:01:12,920
+والـ Medical Genetics الـ References الثانية الـ
+
+15
+00:01:12,920 --> 00:01:18,260
+Summaries والهذه الأشياء يعني أنا بالأول ماحبتش
+
+16
+00:01:18,260 --> 00:01:26,090
+أنينستخدمهم باعتبار أنه فيهم يعني شرح كويس
+
+17
+00:01:26,090 --> 00:01:31,050
+للمفاهيم عبارة عن أسئلة يعني بدك تكون انت مر عليك
+
+18
+00:01:31,050 --> 00:01:37,990
+المفاهيم وهذه بتكون تذكير فيها يعني فإن شاء الله
+
+19
+00:01:37,990 --> 00:01:44,870
+احنا اليوم راح نراجع الأسئلة ويعني
+
+20
+00:01:44,870 --> 00:01:51,890
+حابب ده فيهأنا بشكل عام الأسئلة
+
+21
+00:01:51,890 --> 00:01:57,210
+يعني كانت في كثير منها سهلة يعني في كثير منها
+
+22
+00:01:57,210 --> 00:02:02,990
+difficult index كان مرتفع تقريباً الكل أو نسبة
+
+23
+00:02:02,990 --> 00:02:11,020
+عالية80، 90، 70% جابوها وفي سؤالين، ثلاثة بس اللي
+
+24
+00:02:11,020 --> 00:02:18,380
+فيهم مشاكل كان يعني واحد بس اللي تحت الـ 20% جاوبه
+
+25
+00:02:18,380 --> 00:02:28,020
+صح فممكن احنا نراجع الأسئلة ويعني حابب إنه الـ
+
+26
+00:02:29,230 --> 00:02:34,630
+الطلاب هم اللي جابوا أو على أقل إذا حد عنده أي
+
+27
+00:02:34,630 --> 00:02:38,590
+استفسار في بعضهم بدوا يودوا أسئلة كيف هيك و ليش
+
+28
+00:02:38,590 --> 00:02:45,290
+هيك و كده أحنا ما بديش أقول تغيير بقدر ما أنه
+
+29
+00:02:45,290 --> 00:02:52,590
+اتفقنا مع دارة الكلية أنه مراجع زي الـ USMLE يعني
+
+30
+00:02:52,590 --> 00:02:59,640
+هي تقريبًا كل اللي أنا شرحتهفيها، بس في جوانب يعني
+
+31
+00:02:59,640 --> 00:03:05,620
+على قل «so far» بالنسبة للامتحان الأول فيه نقطتين
+
+32
+00:03:05,620 --> 00:03:10,180
+يعني هيك ببالي أنه نعيد شرحهم بطريقة أو يعني نركز
+
+33
+00:03:10,180 --> 00:03:16,160
+عليهم لأن الواحد لازم يكون منتبه عليهم فالآن
+
+34
+00:03:16,160 --> 00:03:23,940
+يعني بطلب من الشباب الدكاترة والدكتورات أنهيعني
+
+35
+00:03:23,940 --> 00:03:28,720
+بالذات كمان الـ MCQs كأسئلة يعني احنا الغالبية
+
+36
+00:03:28,720 --> 00:03:35,200
+العظمة من الطب والعلم والمبادئ أخدناها يعني تقريبا
+
+37
+00:03:35,200 --> 00:03:41,080
+المفروض الواحد عنده حصيلة جيدة بيظل أنه بده يأخذ
+
+38
+00:03:41,080 --> 00:03:46,780
+حصيلة أخرى من الحالات السريرية ويعني يفكر في
+
+39
+00:03:46,780 --> 00:03:52,120
+الموضوع من خلال الأمراض يعني هيك القصد، فماشي
+
+40
+00:03:52,120 --> 00:03:58,710
+الحالفي أسئلة؟ إن شاء الله يعني أنا يعني في إمكاني
+
+41
+00:03:58,710 --> 00:04:03,770
+أي حد بيقدر يعمل unmute للـ للحساب تبعه ويتكلم مع
+
+42
+00:04:03,770 --> 00:04:09,450
+الدكتور بشكل عام مباشر مافي مشكلة مافي مشكلة هبدأ
+
+43
+00:04:09,450 --> 00:04:19,390
+وسوي share screen عشان بالنسبة لتشوف الأسئلة و
+
+44
+00:04:23,540 --> 00:04:31,460
+انتبهت دكتور أحمد أني أنا هتعطيك واحد وخمسين سؤال
+
+45
+00:04:31,460 --> 00:04:36,360
+مش خمسين، في سؤال كان مشبوك اتنين ببعض، في مرات
+
+46
+00:04:36,360 --> 00:04:45,820
+واحد يعني مهما يبدو الجهد بيظل يعني بيظل في بعض
+
+47
+00:04:45,820 --> 00:04:51,040
+المرات هيك بنتبهش في أشياء و بيحاول أنه يعني
+
+48
+00:04:51,040 --> 00:04:56,130
+يعملها مظبوططيب، لعنة خير، لعنة خير المشكلة
+
+49
+00:04:56,130 --> 00:05:00,850
+الثانية بالنسبة
+
+50
+00:05:00,850 --> 00:05:08,450
+للـ الـ الـ file تبع الـ Excel تبع التقييم الأسئلة
+
+51
+00:05:08,450 --> 00:05:13,390
+عابه أو مشكلته مش بنفس الترتيب اللي أنا أعطيتكميه
+
+52
+00:05:13,390 --> 00:05:21,230
+يعني مرات بكون يعني أنا ماعرفش السؤال الصعب ولا
+
+53
+00:05:21,230 --> 00:05:31,080
+السهلالمهم طيب إحنا المحاضرة اليوم قصيرة إن شاء
+
+54
+00:05:31,080 --> 00:05:39,020
+الله وإذا حد عنده أسئلة هاي موجودة عندكم اللي
+
+55
+00:05:39,020 --> 00:05:47,400
+بتفرج أنا عليه، ماشي؟ الآن النقطة الأولى All are
+
+56
+00:05:47,400 --> 00:05:51,200
+true about the origin of genetics understanding by
+
+57
+00:05:51,200 --> 00:05:52,100
+Mendel except
+
+58
+00:05:54,950 --> 00:06:01,310
+طبعًا يعني دائمًا من الأشياء المفهومة أنه هو اشتغل
+
+59
+00:06:01,310 --> 00:06:05,470
+على الـ Bees ولمّا
+
+60
+00:06:05,470 --> 00:06:11,510
+اشتغل أعلن التجارب تبعته ونشرها بس ما حدا قبلها،
+
+61
+00:06:11,510 --> 00:06:15,690
+ما حدا طلّى عليها يمكن تلاتين سنة بعدين كانوا
+
+62
+00:06:15,690 --> 00:06:20,710
+اكتشفوا وكان هو أول إنسان بتكلم عن صفات سائدة
+
+63
+00:06:20,710 --> 00:06:26,330
+ومتنحيةوكدا، هو درس تمان خواص في الـ… في
+
+64
+00:06:26,330 --> 00:06:33,050
+الـBasella الطول قصيرة ولا طويلة، اللون الجعلقة
+
+65
+00:06:33,050 --> 00:06:37,570
+ولا smooth تاكه، يعني الـSurface تبع حتة
+
+66
+00:06:37,570 --> 00:06:44,630
+الـBasella الـ… الوردة تبعتها طرفية من فوق، يعني
+
+67
+00:06:44,630 --> 00:06:50,150
+بنهاية النبات من فوق ولا بتجند، يعني تمان خواص
+
+68
+00:06:50,700 --> 00:06:59,000
+والحفظ يعني نصيبه كان الملاحظة تبعته إنه بالنسبة
+
+69
+00:06:59,000 --> 00:07:02,860
+له كل الـ traits دولة كانوا على different
+
+70
+00:07:02,860 --> 00:07:09,520
+chromosomes فهذه الصدفة تبعته يعني تظبطت معاه إنه
+
+71
+00:07:09,520 --> 00:07:14,050
+كان عنده segregation of character يعنيإنه ما كان
+
+72
+00:07:14,050 --> 00:07:21,750
+فيه يعني إرتباط بين أي صفتين كان يدرسهم أحيانًا
+
+73
+00:07:21,750 --> 00:07:25,370
+إذا الـ «تو جين» كانت مع نفسها كروموزوم ومرتبطة
+
+74
+00:07:25,370 --> 00:07:32,790
+«تو» كانت مرتبطة مع بعض ويكون فيه اختلاف عن النسب
+
+75
+00:07:32,790 --> 00:07:38,530
+والأشياء اللي جابها فهذه السؤال الأول، فيه أسئلة؟
+
+76
+00:07:39,350 --> 00:07:44,090
+إذا حد عنده أي سؤال يعني أنا بشرح شوه فكرة السؤال
+
+77
+00:07:44,090 --> 00:07:49,950
+الأهمشي إن واحد ياخد الفكرة بغض النظر يعني بدي
+
+78
+00:07:49,950 --> 00:07:55,630
+أتعود على الـArticulation يعني طريقة كتابة السؤال
+
+79
+00:07:55,630 --> 00:08:02,050
+لكل واحد إيه طريقة يعني كأستاذ أو حتى في الـUSMLE
+
+80
+00:08:02,050 --> 00:08:06,600
+يعني من هيك الأشياء اللي لازم تنتبه إلهابالنسبة
+
+81
+00:08:06,600 --> 00:08:10,640
+للـ USMLE مرات بيحطوا أسئلة عشان يقيموا الأسئلة
+
+82
+00:08:10,640 --> 00:08:14,500
+يعني بيكونوا هم مش عارفين لسه هل هذا السؤال واضح،
+
+83
+00:08:14,500 --> 00:08:21,060
+مش واضح، في مرات الإشكالية بتكون إنه الصياغة فيها،
+
+84
+00:08:21,060 --> 00:08:26,580
+يعني أنا بالنسبة لفي سؤال عن، راح نيجي بعدين
+
+85
+00:08:26,580 --> 00:08:30,380
+بتفجيكم إياه الإختلف عن المرة الأولى اللي عملتموها
+
+86
+00:08:30,380 --> 00:08:35,080
+الفاصلة، القامةبجرد إن حطيتها ولا ما حطيتها عشان
+
+87
+00:08:35,080 --> 00:08:41,540
+أفرقت شويه أو أوضحت أكتر السؤال
+
+88
+00:08:41,540 --> 00:08:48,300
+الثاني All are true statements الـGene's
+
+89
+00:08:48,300 --> 00:08:51,760
+definition هو segments of the DNA that get
+
+90
+00:08:51,760 --> 00:08:55,940
+transcribed to RNA and proteins الـGenome هو
+
+91
+00:08:55,940 --> 00:09:00,990
+الـAll genes of a cell أو living organismالـ Human
+
+92
+00:09:00,990 --> 00:09:04,590
+Genome Project قعد حوالي عشر سنين خلصته قريبًا
+
+93
+00:09:04,590 --> 00:09:10,750
+بالـ 2003 أول Whole Genome كان Drosophila اللي هو
+
+94
+00:09:10,750 --> 00:09:16,190
+دبابة الفاكهة دبابة الفاكهة فيها أربع كروموزومات
+
+95
+00:09:16,190 --> 00:09:20,410
+فاعتبروا إنها راح تكون أصغر واحدة وتكون سهلة تنعمل
+
+96
+00:09:20,410 --> 00:09:26,720
+فلما عملوا Sequence كان دا الـDrosophilaالآن
+
+97
+00:09:26,720 --> 00:09:31,220
+الإمكانية عمل الـ Whole-Genome Sequencing وكده
+
+98
+00:09:31,220 --> 00:09:38,100
+بتكون لأن الـ Machinery والتكنولوجيا يعني الآن
+
+99
+00:09:38,100 --> 00:09:45,900
+ملايين المرات الـ… الـMachines تريد الـSequence
+
+100
+00:09:45,900 --> 00:09:50,840
+DNA are much faster، much stronger أحسن من تبعات
+
+101
+00:09:50,840 --> 00:09:59,570
+زمان، كانت أبطأوأقل كفاءة، ماشي، هي أسئلة، فالهنا
+
+102
+00:09:59,570 --> 00:10:03,770
+الـ third genome was for Drosophila، هاي الخطأ
+
+103
+00:10:03,770 --> 00:10:08,730
+السؤال
+
+104
+00:10:08,730 --> 00:10:14,590
+التالت، all are areas used for genetics and
+
+105
+00:10:14,590 --> 00:10:18,590
+genomics؟ الـ cancer، ال forensic medicine، الطب
+
+106
+00:10:18,590 --> 00:10:22,360
+الشرعي؟Disease management and pathogenesis، الـ
+
+107
+00:10:22,360 --> 00:10:26,420
+Transplantation كلهم بدهم الـ Genetics وGenomics
+
+108
+00:10:26,420 --> 00:10:32,040
+الـ Political Science وما له دخل مع أنه يعني مش
+
+109
+00:10:32,040 --> 00:10:38,060
+كتير غلط إنه حتى بالنسبة للسياسة
+
+110
+00:10:38,060 --> 00:10:41,420
+الجينات
+
+111
+00:10:41,420 --> 00:10:46,850
+أحيانًا تدخل في الـيعني في العلوم السياسية،
+
+112
+00:10:46,850 --> 00:10:52,650
+التفريق العنصري يعني
+
+113
+00:10:52,650 --> 00:10:57,530
+فيه مرات أشياء، أفكار يعني القومية العربية مثلا
+
+114
+00:10:57,530 --> 00:11:02,050
+يمكن تعتمد على جينات معينة وكذا القوميات وكذا،
+
+115
+00:11:02,050 --> 00:11:12,670
+يعني السؤال الرابع الـDNA usually is loose the DNA
+
+116
+00:11:12,670 --> 00:11:17,720
+becomes condensedوDensely compacted يعني في أكتر
+
+117
+00:11:17,720 --> 00:11:25,200
+شيء بيسميه كروموزوم It's not a DNA probe
+
+118
+00:11:25,200 --> 00:11:30,980
+الكروماتين هو segment من الكروموزوم بيكون موجود في
+
+119
+00:11:30,980 --> 00:11:37,620
+حالة ما لم يتم استخدامه اللايسوزوم لأ هو vacuole
+
+120
+00:11:37,620 --> 00:11:43,720
+أو organelle in the cell اللايسوزوموالـ
+
+121
+00:11:43,720 --> 00:11:49,340
+Environmental factors ما لهم بحاجة آه يا محمود إذا
+
+122
+00:11:49,340 --> 00:11:52,600
+في سؤال؟
+
+123
+00:11:52,600 --> 00:11:56,900
+في حد رفع إيده؟
+
+124
+00:11:56,900 --> 00:12:08,360
+تقريباً لأ طيب، ليش هيكي هذا؟ بس ثواني، خليني
+
+125
+00:12:13,390 --> 00:12:21,210
+مرة تانية حاول
+
+126
+00:12:21,210 --> 00:12:33,050
+أنزل تحت طيب لما
+
+127
+00:12:33,050 --> 00:12:37,850
+نكون، احنا يعني لازم نفكر بالنسبة للـGenetic
+
+128
+00:12:37,850 --> 00:12:42,750
+Diseases into three types، main typesفي الـ
+
+129
+00:12:42,750 --> 00:12:48,530
+Mendelian هو اللي هو بيكون single gene disease due
+
+130
+00:12:48,530 --> 00:12:56,870
+to single gene الـ other type بيكون many يعني
+
+131
+00:12:56,870 --> 00:13:01,410
+whole segment of either the whole chromosome أو
+
+132
+00:13:01,410 --> 00:13:04,630
+segment of ال chromosome بنسميه chromosomal
+
+133
+00:13:04,630 --> 00:13:09,450
+diseaseماشي، Multiple genes مع بعض ويكون ده هو
+
+134
+00:13:09,450 --> 00:13:13,070
+الـChromosome يعني زي الـDown Syndrome، Turner,
+
+135
+00:13:13,490 --> 00:13:17,470
+Klinefelter أشياء زي هيك، بدنا نسميها Chromosomes
+
+136
+00:13:17,470 --> 00:13:27,330
+البقية Epigenetic وPolygenic دولة عبارة عن اللي هو
+
+137
+00:13:27,330 --> 00:13:31,070
+إحنا بنعتبرهم الـFair Type ولي هم الـCommunist
+
+138
+00:13:31,070 --> 00:13:37,100
+اللي هي بتكون Multifactorialيعني بالنسبة للـGenes،
+
+139
+00:13:37,100 --> 00:13:39,440
+الـGenetic Involvement «هناك تجارب تجارب تجارب
+
+140
+00:13:39,440 --> 00:13:44,780
+تجارب» Definite، Familial، منتشر أكتر بين
+
+141
+00:13:44,780 --> 00:13:50,640
+الـFamilies بس بتكون مش جين واحد ولا مجموعة جينات،
+
+142
+00:13:50,640 --> 00:13:55,060
+يعني مجموعة جينات متفرقة بس مش في كرومزوم واحد ولا
+
+143
+00:13:55,060 --> 00:13:58,560
+في segment of the chromosome short arm، long arm
+
+144
+00:13:58,560 --> 00:14:03,560
+of a chromosome مثلا ولا كده، لأ ما بتكونفهي لما
+
+145
+00:14:03,560 --> 00:14:07,660
+تكون segment of many hundreds of thousands of
+
+146
+00:14:07,660 --> 00:14:15,100
+genes بتكون في الـChromosome الآن الـMicrobiome
+
+147
+00:14:15,100 --> 00:14:23,700
+يعني على كلمة genome –ome تعني اللي هي موضوع كل
+
+148
+00:14:23,700 --> 00:14:28,660
+الجينات تبعات الإنسان أو تبعات الخلية، أي خلية
+
+149
+00:14:28,660 --> 00:14:35,480
+بيكونيعني مثلًا نقول Cat Genome يعني للبس أجي أبحث
+
+150
+00:14:35,480 --> 00:14:42,320
+الـ DNA كله فالـ Genome هو وصف لكل الجينة فبنفس
+
+151
+00:14:42,320 --> 00:14:48,300
+الطريقة في طرق الآن نستخدم بيسموه الـ Microbiome
+
+152
+00:14:48,300 --> 00:14:57,050
+الـ Microbiome اللي هو بدرسه بشكل محدد أنواعالـ
+
+153
+00:14:57,050 --> 00:15:03,350
+Ribosomal RNA of the bacteria وبندرس، يعني بناخد
+
+154
+00:15:03,350 --> 00:15:09,090
+مثلاً سامبل من الـ Gut سامبل من الـ Skin بكتيريا
+
+155
+00:15:09,090 --> 00:15:13,610
+أو Gut بكتيريا أو Respiratory tract بكتيريا،
+
+156
+00:15:13,610 --> 00:15:20,950
+Mycosis وبندرس كل أنواع الـ RNA وRibosomal RNA
+
+157
+00:15:20,950 --> 00:15:25,640
+تبعتها فبنعرف الـ Species تبعت البكتيريافدراسة
+
+158
+00:15:25,640 --> 00:15:31,200
+كاملة لهذا الموضوع اسمها «microbiome» أحياناً الـ
+
+159
+00:15:31,200 --> 00:15:34,700
+«epigenetics» اللي هي «regulation of the genetics»
+
+160
+00:15:34,700 --> 00:15:39,740
+أي ما أنا ذكرته «metabolome» «metabolosome» اللي
+
+161
+00:15:39,740 --> 00:15:49,820
+هو أو «exposome» هو برضه طرق دراسة بشكل كامل مجمل
+
+162
+00:15:49,820 --> 00:15:56,030
+العوامل المؤثرة على الإنسانيعني مثلًا بالنسبة
+
+163
+00:15:56,030 --> 00:16:03,630
+لنوعية غذائنا شو من المكونات تبعته هي بشكل مجمل مش
+
+164
+00:16:03,630 --> 00:16:12,930
+بشكل فردي وشكل موحد فالـMicrobiome والـGenome
+
+165
+00:16:12,930 --> 00:16:17,910
+والـExposome لازم يعني المفاهيم اللي واحد يكون
+
+166
+00:16:17,910 --> 00:16:19,550
+عارفها ضروري يفهمها
+
+167
+00:16:22,810 --> 00:16:27,950
+سؤال السابع الـ
+
+168
+00:16:27,950 --> 00:16:34,510
+Somatic cells عكس الـ Gonads 97% من الـ DNA هو الـ
+
+169
+00:16:34,510 --> 00:16:40,770
+Nuclear DNA ويكون بالـ Nucleus الـ 3% يكون في
+
+170
+00:16:40,770 --> 00:16:47,570
+الميتوكندرية الميتوكندرية نفسها بالنسبة للـ A
+
+171
+00:16:47,570 --> 00:16:51,410
+طبعاً موجودة في الـ Botمايلز وفيميلز أنه
+
+172
+00:16:51,410 --> 00:16:54,450
+ميتوكندرية في كل خلية ففي جزء منها الـ
+
+173
+00:16:54,450 --> 00:16:58,970
+mitochondrial chromosomes وبتكون تبتد لحوالي 3% من
+
+174
+00:16:58,970 --> 00:17:03,890
+الـ DNA الـ mitochondrial chromosomes found in the
+
+175
+00:17:03,890 --> 00:17:07,710
+site of LASK الـ inheritance of mitochondrial DNA
+
+176
+00:17:07,710 --> 00:17:11,970
+is not similar لـ nuclear DNA، هذه الإجابة الـ
+
+177
+00:17:11,970 --> 00:17:17,010
+nuclear DNA نص من الأب ونص من الأم ال
+
+178
+00:17:17,010 --> 00:17:23,410
+mitochondrial DNAوكون فقط من طريق الأم الـ spare
+
+179
+00:17:23,410 --> 00:17:33,910
+مافي micro-conditioning ماشي و .. في طلاب طبعا
+
+180
+00:17:33,910 --> 00:17:44,270
+سؤال خمسة و انا و سؤال خمسة اه اذا
+
+181
+00:17:44,270 --> 00:17:56,630
+ال .. لما يكونproblem كثرة قلة عدم وجود تكرار كذا
+
+182
+00:17:56,630 --> 00:18:04,510
+لعدد كبير من الجينات نسميه chromosomal disease هذا
+
+183
+00:18:04,510 --> 00:18:11,210
+أقرب إشي، شايف عليه؟ segment معين، من داليا بدا
+
+184
+00:18:11,210 --> 00:18:15,530
+تكون one gene فقطكل الـExamples اللي كنت أعطيكوا
+
+185
+00:18:15,530 --> 00:18:19,490
+بيها مندليان، هي مندليان الـDown Syndrome، Client
+
+186
+00:18:19,490 --> 00:18:25,710
+Filter، Turner، أشياء زي هيك، هي الـChromosomal
+
+187
+00:18:25,710 --> 00:18:31,790
+Disease، هاي هي اللي بالسؤال، شو المشكلة؟ –أقصد
+
+188
+00:18:31,790 --> 00:18:37,210
+أنه ليش كل الـGenetic تطلع خطأ؟ –إيش هو؟ –ليش كل
+
+189
+00:18:37,210 --> 00:18:40,010
+الـGenetic تطلع خطأ، اللي هو الطيار دال؟ –كل
+
+190
+00:18:40,010 --> 00:18:44,690
+الـGeneticاللي هي لما الـ Disease مثلًا زي الربو
+
+191
+00:18:44,690 --> 00:18:53,310
+الربو بقدره إنه تقريبًا طبعًا الربو مثلًا فيه واضح
+
+192
+00:18:53,310 --> 00:18:58,630
+إنه فيه genetic factor يعني بتلاقي العيل أو
+
+193
+00:18:58,630 --> 00:19:02,930
+الإنسان المصاب في الغالب كمان في أعضاء تعائلته
+
+194
+00:19:02,930 --> 00:19:07,310
+مصابين أكثر من الـ General Population فبيعتبروا
+
+195
+00:19:07,310 --> 00:19:13,140
+هذا مؤشر على إنهفيه رولة جينية بس لما حاولوا
+
+196
+00:19:13,140 --> 00:19:17,080
+يعزلوا إيش الجين اللي بيعمل هذه المشكلة لقوم حوالي
+
+197
+00:19:17,080 --> 00:19:22,720
+خمسين جين وفي أماكن متفرقة فاهم عليك كده؟ يعني
+
+198
+00:19:22,720 --> 00:19:32,740
+الـIgE-Receptor جين Interleukin-4 نفسه Interleukin
+
+199
+00:19:32,740 --> 00:19:37,840
+-4-Receptor جين يعني في مجموعة جينات بتشترك في هذا
+
+200
+00:19:37,840 --> 00:19:42,680
+الموضوعوهدولة ما بيكونوا جنب بعض، ما بيكونوا مع
+
+201
+00:19:42,680 --> 00:19:48,960
+بعض فلما نكون، يعني لما أنت تيجي تاخد أنه أنا
+
+202
+00:19:48,960 --> 00:19:52,580
+بقولك أنه فيه عدد كبير من الجينات والمتوسط، هذا
+
+203
+00:19:52,580 --> 00:19:58,580
+سؤال راح ييجي بعدين أنه المتوسط عدد الجينات متوسط
+
+204
+00:19:58,580 --> 00:20:06,400
+في الـChromosome هو ألف جين أو مئات على الأقلفأقرب
+
+205
+00:20:06,400 --> 00:20:10,620
+شيء للـ Definition اللي مش Polygenic لما نقول
+
+206
+00:20:10,620 --> 00:20:16,720
+Polygenic المقصود فيه مجموعة جينات متعددة في أماكن
+
+207
+00:20:16,720 --> 00:20:21,600
+مختلفة مش هيك Signal ما بتكون على شكل Signal
+
+208
+00:20:21,600 --> 00:20:29,540
+فحاولت أحط الـ Definition كلمات أكتر عشان أوجه إنه
+
+209
+00:20:29,540 --> 00:20:35,550
+Chromosomal Disease مش Polygenicيعني هو صبعًا Poly
+
+210
+00:20:35,550 --> 00:20:41,250
+هي فيها عدد كبير بس مش هذا المفروض تبعها الـ
+
+211
+00:20:41,250 --> 00:20:45,030
+Polygenic بدخل فيها الـ Epigenetic يعني برضه
+
+212
+00:20:45,030 --> 00:20:51,730
+بتعتبر الـ Epigenetic والـ Polygenic متقاربة يعني
+
+213
+00:20:51,730 --> 00:21:00,470
+الـ Polygenicنتكلم عن ما يمكن يكون ميوتاشيا وطفرات
+
+214
+00:21:00,470 --> 00:21:05,190
+في نفس الجين اللي بسبب المرض بطريقة معينة والـ
+
+215
+00:21:05,190 --> 00:21:10,990
+Epigenetic هي طريقة تفعيله يعني بتلاقي اثنين
+
+216
+00:21:10,990 --> 00:21:17,090
+إنسانين، شخصين عندهم نفس الجين، في واحد شغال، في
+
+217
+00:21:17,090 --> 00:21:22,250
+واحد مش شغال هائل أو شغال كتير ومش شغال كتير،
+
+218
+00:21:22,250 --> 00:21:23,470
+هذولة Epigenetic
+
+219
+00:21:25,910 --> 00:21:31,790
+ماشي؟ إذا في أياسي لإسأله وخلّينا يعني مع الدكتور
+
+220
+00:21:31,790 --> 00:21:37,790
+ماني ماشي تحكولي، ماشي؟ دكتور يعني نفهم الـGeta
+
+221
+00:21:37,790 --> 00:21:42,350
+إنه طالما على أكتر من جين على نفس الـsegment
+
+222
+00:21:42,350 --> 00:21:44,710
+معناها كرمزومة أما إذا كانت أكتر من segment معناها
+
+223
+00:21:44,710 --> 00:21:49,710
+polygenetic، هيك المقصود؟ segment لما نقول عن
+
+224
+00:21:49,710 --> 00:21:55,200
+الـDNAيعني اللي هو الـ Bands و الـ و الـ
+
+225
+00:21:55,200 --> 00:22:00,540
+Chromosome نفسه الـ Big Arm و الـ Short Arm هدولة
+
+226
+00:22:00,540 --> 00:22:04,160
+بيكون فيهم Hundreds of Genes على الأقل أو Thousand
+
+227
+00:22:04,160 --> 00:22:08,140
+ماشي، فهدولة Chromosomal يعني الـ Chromosome هو
+
+228
+00:22:08,140 --> 00:22:12,920
+segment من الـ DNA إنه 64 Chromosome، 46
+
+229
+00:22:12,920 --> 00:22:19,020
+Chromosome و بيكون فيه مشكلة في واحد منهمفلما يكون
+
+230
+00:22:19,020 --> 00:22:23,540
+كل الـ Chromosome الـ Chromosome من 1 إلى 22 والـ
+
+231
+00:22:23,540 --> 00:22:28,740
+X والـ Y فبصير فيهم مشكلة، هذه اسمها Chromosomal
+
+232
+00:22:28,740 --> 00:22:36,980
+القريب منه مثلا في سؤال راح يجينا مريضة عندها، شو
+
+233
+00:22:36,980 --> 00:22:42,620
+اسمه؟ عندها، بتخلف الناس عندهم Down وصار عندها
+
+234
+00:22:42,620 --> 00:22:47,870
+Trisomy 21 إنه Translocationمن الـ Short-arm تبع
+
+235
+00:22:47,870 --> 00:22:51,390
+الـ ما هو فيه بعض الـ Short-arm مافيش فيها
+
+236
+00:22:51,390 --> 00:22:54,430
+كرموزومات كتير يعني هي قطعة من الـ chromosome
+
+237
+00:22:54,430 --> 00:22:59,890
+بتقول long أو short-arm زايدة، ناقصة، متغيرة، كده
+
+238
+00:22:59,890 --> 00:23:06,770
+فلما يكون definitely الـC والـD والـE والـA ما
+
+239
+00:23:06,770 --> 00:23:12,050
+بتظبط أقرب واحد لل definition اللي هو إنه اللي فيه
+
+240
+00:23:12,050 --> 00:23:16,170
+كرموزومة ماشي؟
+
+241
+00:23:22,680 --> 00:23:32,140
+سؤال تمانية ماشي الإجابة
+
+242
+00:23:32,140 --> 00:23:38,380
+Which statement about DNA is correct الـ backbone
+
+243
+00:23:38,380 --> 00:23:43,680
+هما الـ sugar و الـ phosphate الـ nitrogen base
+
+244
+00:23:43,680 --> 00:23:48,980
+اعتبرنا زي السلم في درجات السلم الـ nitrogen bases
+
+245
+00:23:49,990 --> 00:23:54,830
+الـ Sugar part، الـ DNA، الـ Deoxyribose، مش
+
+246
+00:23:54,830 --> 00:24:00,010
+Ribose الـ phosphate group alternates with the
+
+247
+00:24:00,010 --> 00:24:02,850
+sugar one in the backbone، هي الإيجابة الصحيحة
+
+248
+00:24:02,850 --> 00:24:07,090
+الأدينين والجوانين هم الـ Purines التايمين
+
+249
+00:24:07,090 --> 00:24:13,290
+والسايتوزين هم البريميدين، عكستهم، فهذه هي المفروض
+
+250
+00:24:13,290 --> 00:24:13,990
+أنها واضحة
+
+251
+00:24:17,370 --> 00:24:23,590
+لما نستخدم X-Ray Crystallography هذه الطريقة اللي
+
+252
+00:24:23,590 --> 00:24:29,510
+هي…–السؤال من نائل بالنسبة لسؤال سبعة نعم، الأولى
+
+253
+00:24:29,510 --> 00:24:36,290
+صح ليش، استنى علي أشوف سؤال سبعة أه، الأولى صح
+
+254
+00:24:36,290 --> 00:24:41,710
+طبعا الناقل،
+
+255
+00:24:41,710 --> 00:24:46,500
+يعني الـMitochondrial DNA موجودالـ Males و الـ
+
+256
+00:24:46,500 --> 00:24:49,560
+Females عندهم Mitochondria أي خلية Male و Female
+
+257
+00:24:49,560 --> 00:24:54,540
+فيها Mitochondria بس الـ الـ الوراثة تبعته هي اللي
+
+258
+00:24:54,540 --> 00:24:58,040
+فيها اختلاف الوراثة تبعته بالنسبة لـ Mitochondrial
+
+259
+00:24:58,040 --> 00:25:04,680
+DNA عن طريق الأم فقط لأن الـ الـ الـ Spare مافيه
+
+260
+00:25:04,680 --> 00:25:09,240
+Mitochondrial مافيه Mitochondrial ماشي اللي بيشترك
+
+261
+00:25:09,240 --> 00:25:14,460
+يعني اللي الطاقة في الـ Spare ماحتخده في منطقة الـ
+
+262
+00:25:14,460 --> 00:25:20,580
+Neckوالرأس تبعه اللي فيه الـ Tail فالـ Tail بتحرك
+
+263
+00:25:20,580 --> 00:25:25,580
+عشان يخلّي الـ Sperm يمشي بس الـ Mitochondria اللي
+
+264
+00:25:25,580 --> 00:25:29,120
+بدها طاقة موجودة في الـ Nucleus ما بتدخل في الـ
+
+265
+00:25:29,120 --> 00:25:35,660
+Fertilized egg لما يجي الـ Sperm يلقّع الـ يعني
+
+266
+00:25:35,660 --> 00:25:41,500
+الميتوكندريا الـ DNA موجودين في اثنين الميتوكندريا
+
+267
+00:25:41,500 --> 00:25:48,070
+والـ DNA تبعها موجودة بسبالنسبة للـ Inheritance
+
+268
+00:25:48,070 --> 00:25:52,770
+والاقتلاف فالسؤال
+
+269
+00:25:52,770 --> 00:25:59,310
+الإجابي إيه؟ هي جملة صحيحة ومش غلط أما الـ D هي
+
+270
+00:25:59,310 --> 00:26:05,310
+الغلط واضح؟
+
+271
+00:26:05,310 --> 00:26:08,370
+أنا هنا ما يعني ال male و ال female لازم يكون
+
+272
+00:26:08,370 --> 00:26:12,920
+عندهم mitochondria بس ال malesالـ Mitochondrial
+
+273
+00:26:12,920 --> 00:26:21,900
+تبعته ما بتنتقل للبنات ولأولاد كان من الأم فقط لما
+
+274
+00:26:21,900 --> 00:26:26,600
+نيجي نتفرج بالـ X-Ray Crystallography وقدنا نشوف
+
+275
+00:26:26,600 --> 00:26:31,620
+at a very يعني low level of my resolution الـ 2
+
+276
+00:26:31,620 --> 00:26:37,440
+نانومتر نشوف الـ Double Helix للـ DNA باستخدام الـ
+
+277
+00:26:37,440 --> 00:26:43,500
+X-Ray Crystallographyبيخلّوا المادة تلاقي الـ DNA
+
+278
+00:26:43,500 --> 00:26:50,720
+تأخذ شكل كريستال، ماشي، وبعدين they shine X-ray on
+
+279
+00:26:50,720 --> 00:26:55,720
+them وبيشوفوا كيف الـ reflection تبعتها، شو
+
+280
+00:26:55,720 --> 00:27:00,300
+الانطباع، شو الصورة راح تطلع، بيستنتجوا منها كيف
+
+281
+00:27:00,300 --> 00:27:04,240
+الـ structure تبع هذه البلّورة طبعاً بيخلّوه لازم
+
+282
+00:27:04,240 --> 00:27:11,850
+يتبلر، يصير على شكل بلّورةالـ average number of
+
+283
+00:27:11,850 --> 00:27:19,550
+genes per chromosome تقريبًا ألف يعني هيك بالمتوسط
+
+284
+00:27:19,550 --> 00:27:25,190
+في بعض الجينات very little زي الـ Y-chromosome
+
+285
+00:27:25,190 --> 00:27:30,770
+مافيش فيه كتير، قصير وصغير وبالنسبة مثلًا زي
+
+286
+00:27:30,770 --> 00:27:34,690
+chromosome 1 very large يمكن فيه حوالي 2000 gene
+
+287
+00:27:34,690 --> 00:27:44,960
+فالـ averageتقريبًا L يعني Recall بالنسبة للـ Cell
+
+288
+00:27:44,960 --> 00:27:53,680
+Cycle أو Cell Division Cycle بنقسمها G0 لما يكون
+
+289
+00:27:53,680 --> 00:28:00,580
+الخلايا بطلت تنقسم أو بدهاش تنقسم وملاجئها عادة
+
+290
+00:28:00,580 --> 00:28:05,360
+الخلايا المنقسمة لما تنقسم بتكون في مرحلة نسميها
+
+291
+00:28:05,360 --> 00:28:10,410
+G1يعني اللي هي الخلية العادية الخلية اللي بتكون
+
+292
+00:28:10,410 --> 00:28:16,490
+«between divisions» وبتقدر وظيفتها لما تقرر إنها
+
+293
+00:28:16,490 --> 00:28:22,470
+تنقسم أو اللي جيها أمر إنها تنقسم بتصير الـS-phase
+
+294
+00:28:22,470 --> 00:28:27,190
+اللي هي هنا
+
+295
+00:28:27,190 --> 00:28:30,870
+«all are through stages of self-divisional cycle
+
+296
+00:28:30,870 --> 00:28:37,440
+except» الـS-phase، لأ، هاي صح، أنا شو حطينا؟All
+
+297
+00:28:37,440 --> 00:28:41,880
+are true stages الـ G0 اللي هي when cells are not
+
+298
+00:28:41,880 --> 00:28:47,960
+dividing، صحيح الـ G1 الـ cells between divisions،
+
+299
+00:28:47,960 --> 00:28:55,740
+صحيح الـ S phase هي الـ
+
+300
+00:28:55,740 --> 00:28:59,080
+M phase when the cell division occurs، G2 phase
+
+301
+00:28:59,080 --> 00:29:03,200
+when cell prepares، صحيح
+
+302
+00:29:04,880 --> 00:29:09,360
+دكتور يا عفوا يا هذا السؤال كل إجابته صح أتوقع هيك
+
+303
+00:29:09,360 --> 00:29:14,920
+صحيح أنا خربطت في ال .. يعني كل اللي بيطلع عن
+
+304
+00:29:14,920 --> 00:29:19,740
+الجوابات صحيح يعني نعم ماشي يعني يعني يا دكتور هذا
+
+305
+00:29:19,740 --> 00:29:24,340
+.. هذا بنشيله يعني إيش يعني .. ماشي هذا بنشيله هذا
+
+306
+00:29:24,340 --> 00:29:28,820
+بنشيله مافي مشكلة أه دكتور أحمد؟ تمام ان شاء الله
+
+307
+00:29:28,820 --> 00:29:34,660
+بنخدف السؤال ما .. ما تقلبك أه ماشياللي أنا
+
+308
+00:29:34,660 --> 00:30:02,180
+بكون…………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………�
+
+309
+00:30:02,540 --> 00:30:06,400
+دكتور بنفع تخليه bonus بدل ما تحزفه لأنه ضيع نوجت
+
+310
+00:30:06,400 --> 00:30:08,720
+و احنا بنستلقع في السؤال يمكن نقعدنا تلت دقايق او
+
+311
+00:30:08,720 --> 00:30:11,700
+اكتر و احنا بنتحيرنا في السؤال ازاي أنا بالنسبة
+
+312
+00:30:11,700 --> 00:30:17,900
+لدكتور أحمد بشوفي دكتور أحمد اسمع علي كداش ال
+
+313
+00:30:17,900 --> 00:30:21,680
+average و كداش ال standard deviation شوق على علامة
+
+314
+00:30:21,680 --> 00:30:27,080
+و أوطة علامة للأسف يعني في من ناحية أوطة علامة في
+
+315
+00:30:27,080 --> 00:30:32,840
+يعنيثمن طلاب تحت الخمستاش أعلى علام تسعة و عشرين
+
+316
+00:30:32,840 --> 00:30:37,300
+محدش جاب تلاتين تسعة
+
+317
+00:30:37,300 --> 00:30:41,440
+و عشرين من خمسين تسعة و عشرين من تلاتين تسعة و
+
+318
+00:30:41,440 --> 00:30:41,600
+عشرين من تلاتين تسعة و عشرين من تلاتين تسعة و
+
+319
+00:30:41,600 --> 00:30:43,360
+عشرين من تلاتين تسعة و عشرين من تلاتين تسعة و
+
+320
+00:30:43,360 --> 00:30:44,800
+عشرين تلاتين تسعة و عشرين تلاتين تسعة و عشرين
+
+321
+00:30:44,800 --> 00:30:48,240
+تلاتين تسعة و عشرين تلاتين تسعة و عشرين تلاتين
+
+322
+00:30:48,240 --> 00:30:51,420
+تسعة و عشرين تلاتين تلاتين تلاتين تلاتين تلاتين
+
+323
+00:30:51,420 --> 00:30:52,340
+تلاتين تلاتين تلاتين تلاتين تلاتين تلاتين تلاتين
+
+324
+00:30:52,340 --> 00:30:59,540
+تلاتين تلاتين تلوالله بدك تخليه خليه الـ Average
+
+325
+00:30:59,540 --> 00:31:05,520
+إذا يعني أنا شايف هيك يعني فيه good distribution
+
+326
+00:31:05,520 --> 00:31:10,440
+يعني معناته الأسئلة أنا بشوف إن الأسئلة كانت بشكل
+
+327
+00:31:10,440 --> 00:31:14,940
+عام مقبولة فيه كتير علامات كاملة كان فيها تقريبا
+
+328
+00:31:14,940 --> 00:31:18,580
+يعني فيه عدد أسئلة كويس وفيها أسئلة كان فيها خربطة
+
+329
+00:31:19,110 --> 00:31:26,170
+يعني يمكن هذا السؤال اللي يمكن خربط الطلاب على كله
+
+330
+00:31:26,170 --> 00:31:30,550
+شوف إدارة الكلية أنا ماعندي مشكلة خلّيه bonus إذا
+
+331
+00:31:30,550 --> 00:31:37,650
+كان بدك تعتبره هيك تعيد التصليح و تخليه أو تحذفه و
+
+332
+00:31:37,650 --> 00:31:41,190
+تعيد التصليح مرة تانية برضه بيصير يعني bonus،
+
+333
+00:31:41,190 --> 00:31:47,270
+bonus أكثر، bonus أكثر ماشي، ماشيماشي إن شاء الله
+
+334
+00:31:47,270 --> 00:31:50,750
+بالنسبة
+
+335
+00:31:50,750 --> 00:31:55,550
+للـ Stages، الـ Cell Division هذه يعني، بالذات لما
+
+336
+00:31:55,550 --> 00:32:01,130
+واحد يرجع للتبعات الـ USMLE بتلاقي في عليها أسئلة
+
+337
+00:32:01,130 --> 00:32:08,330
+و لازم الواحد يحفظهم و بنتي علمتني بيقولها P-Math
+
+338
+00:32:08,330 --> 00:32:14,430
+ماشي؟ اللي إن حتى الواحد يحفظ الـ Stages ماشي؟
+
+339
+00:32:16,350 --> 00:32:22,270
+بالأول الـ Prophase، Metaphase أول شي Prophase،
+
+340
+00:32:22,270 --> 00:32:25,270
+بعدين Pro-Metaphase، بعدين Metaphase، Anaphase،
+
+341
+00:32:25,270 --> 00:32:32,690
+Telophase، فبالأخير MAD وبالأول P، P، P، P، MAD
+
+342
+00:32:32,690 --> 00:32:37,630
+فالآن which stage of cell division by mitosis
+
+343
+00:32:38,240 --> 00:32:43,140
+بالتالي كان هناك مبنى نوكليار والـ Centromere لسه
+
+344
+00:32:43,140 --> 00:32:49,340
+هي أول واحدة أول بداية فتكون الـ Prophase البقية
+
+345
+00:32:49,340 --> 00:32:53,840
+مايكونش فيه مبنى نوكليار الـ Centromere الـ
+
+346
+00:32:53,840 --> 00:32:59,420
+Centrosome بيكون موجود ويبدأ يتكون حتى يفصل
+
+347
+00:32:59,420 --> 00:33:06,400
+الكرمزومات عن بعض هذه
+
+348
+00:33:06,400 --> 00:33:07,320
+الـ Prophase
+
+349
+00:33:10,580 --> 00:33:14,700
+الأن الـ «Chromosomes are arranged in the middle
+
+350
+00:33:14,700 --> 00:33:18,400
+with microtubules directing them to the central
+
+351
+00:33:18,400 --> 00:33:22,100
+zones» اللي هي بتبدأ في حالة الـ «Metaphase» لما
+
+352
+00:33:22,100 --> 00:33:26,960
+تترتب في هذه الشغل بعدين بيبدو ينشدوا على الجهتين
+
+353
+00:33:26,960 --> 00:33:31,020
+وينفصلوا الـ «Anaphase» وبس يخلص يبتدلوا «Phase»
+
+354
+00:33:31,020 --> 00:33:33,360
+ترجع الـ «Nuclear Membrane» تنفصل
+
+355
+00:33:36,720 --> 00:33:42,080
+الـ Usual Karyotyping و Binding of chromosomes الـ
+
+356
+00:33:42,080 --> 00:33:49,860
+Right Stain بالنسبة لنا نستخدمه زي نلسان للـ TD
+
+357
+00:33:49,860 --> 00:33:52,940
+همتوكسلينيوسين
+
+358
+00:33:52,940 --> 00:33:58,300
+للـ Stain والـ Gram Stain للبكتيريا، ماعناش دخل
+
+359
+00:33:58,300 --> 00:34:02,380
+الـ Right Stain للـ Red و Blood Cell و الـ
+
+360
+00:34:02,380 --> 00:34:05,360
+Hematology بس اللي بيستخدم الـ Gemma Stain
+
+361
+00:34:09,510 --> 00:34:13,390
+بالنسبة لـ stage of cell division الـ two gametes
+
+362
+00:34:13,390 --> 00:34:18,130
+at the end of meiosis بكون اللي هي الـ Anaphase 2
+
+363
+00:34:18,130 --> 00:34:23,090
+حتى
+
+364
+00:34:23,090 --> 00:34:27,530
+أنا يعني طبعاً بدنا نلاحظ الـ meiosis فيه two
+
+365
+00:34:27,530 --> 00:34:33,500
+stages Stage 1 و Stage 2فالواحد في بعضها حطيت يعني
+
+366
+00:34:33,500 --> 00:34:38,680
+يمكن كانت لو في تيلو phase two يمكن أظبط أحسن أقرب
+
+367
+00:34:38,680 --> 00:34:44,440
+بين الأنا والتيلو بالأخير بس لازم كتو أنا phase
+
+368
+00:34:44,440 --> 00:34:49,160
+two مش الـmetaphase ولا الـbrometaphase الـphase
+
+369
+00:34:49,160 --> 00:34:55,980
+one ما بيكونش بنقسم لتو جميت لسه في الـG2 phase
+
+370
+00:34:55,980 --> 00:35:01,600
+الـDNA content is 4L normallyخلّيه لما بدأ تنقسم
+
+371
+00:35:01,600 --> 00:35:07,020
+بالـG2 بالـMyotosis
+
+372
+00:35:07,020 --> 00:35:13,680
+بدأ تكون شو اسمه؟ 4M يعني صار الـS-Phase وصار
+
+373
+00:35:13,680 --> 00:35:18,380
+الـDuplication للـDNA لأن
+
+374
+00:35:18,380 --> 00:35:24,970
+all are true statements about the genomeالكثيرية
+
+375
+00:35:24,970 --> 00:35:28,170
+العامة من الـ DNA في جسد الإنسان هي الـ Coding
+
+376
+00:35:28,170 --> 00:35:33,590
+للبروتينات المهمة، لأ 4، 5% بس في الـ Human Genome
+
+377
+00:35:33,590 --> 00:35:38,790
+وهذا عكس كثير من الكائنات الحي الأخرى يعني هذا
+
+378
+00:35:38,790 --> 00:35:43,390
+الجانب يمكن الواحد جيد إن يطلع عليه الكائنات
+
+379
+00:35:43,390 --> 00:35:51,660
+الثانية يعني الـ DNA أو المادة الوراثية سبعتهاحتى
+
+380
+00:35:51,660 --> 00:35:57,880
+تستخدم بشكل كثيف لإنتاج البروتينات واللي يكون
+
+381
+00:35:57,880 --> 00:36:03,300
+coding الـDNA بينما الإنسان من الكائنات، يعني
+
+382
+00:36:03,300 --> 00:36:06,860
+الأشياء اللي بيكون فيها الـnon-coding هو
+
+383
+00:36:06,860 --> 00:36:13,800
+الـmajority الـGenes are transcribed وبعدين
+
+384
+00:36:13,800 --> 00:36:18,880
+manipulated بالـSplicing عشان الـMessenger RNA
+
+385
+00:36:20,150 --> 00:36:25,410
+باستخدام إزالة الـ Intron صحيحة الـ Messenger RNA
+
+386
+00:36:25,410 --> 00:36:32,910
+تترجم إلى البروتينات صحيح الترجمة حصلت في النوكليا
+
+387
+00:36:32,910 --> 00:36:37,390
+والترجمة في مكان الأرض صحيح الـ Polypeptide Chains
+
+388
+00:36:37,390 --> 00:36:42,130
+تم تغييرها بعد ذلك بإزالة الجلد والميكانيزمات
+
+389
+00:36:42,130 --> 00:36:49,270
+الصحيحة فهذه كل جمل صحيحة ما كانت الأولى الآن
+
+390
+00:36:51,110 --> 00:36:56,870
+كلها اختلافات حقيقية إلا أن الفوسفات هي نفسها
+
+391
+00:36:56,870 --> 00:37:03,130
+الاختلاف في الـ DNA، الشجر هو ديوكسي، ليس الريبوز
+
+392
+00:37:03,130 --> 00:37:08,550
+في الـUracil والثامين، فيه اختلاف بينهم الـ DNA
+
+393
+00:37:08,550 --> 00:37:14,230
+دائماً عاديةً مجموعة مدعومة بس فيه مجموعة مدعومة
+
+394
+00:37:14,230 --> 00:37:18,530
+DNA ممكن نصنع، ممكن بعض الفيروسات فيها مجموعة
+
+395
+00:37:18,530 --> 00:37:23,420
+مدعومة DNA، تصيربس الـ most of the DNA is double
+
+396
+00:37:23,420 --> 00:37:27,300
+-stranded و الـ most of the RNA is single
+
+397
+00:37:27,300 --> 00:37:32,020
+-stranded، هيك بسيطة either can be the genetic
+
+398
+00:37:32,020 --> 00:37:36,040
+source of living material، صحيح ذات الـ viruses
+
+399
+00:37:36,040 --> 00:37:43,520
+بعضهم DNA viruses بعضهم RNA virus يعني، بالتالي،
+
+400
+00:37:43,520 --> 00:37:50,040
+can be for both، ماشي؟ فالـ phosphate group مافي
+
+401
+00:37:50,040 --> 00:37:50,860
+اختلاف تاني
+
+402
+00:37:54,290 --> 00:37:58,590
+بالنسبة لـ All are true statements about reading
+
+403
+00:37:58,590 --> 00:38:03,830
+the DNA into finally proteins الـ Always read from
+
+404
+00:38:03,830 --> 00:38:09,790
+five prime to three prime direction صحيح لأنه
+
+405
+00:38:09,790 --> 00:38:16,530
+في عنا twenty different amino acids وعندي four
+
+406
+00:38:16,530 --> 00:38:19,390
+nitrogen bases ماشي
+
+407
+00:38:21,150 --> 00:38:27,250
+يعني بيعطيني أربعة nucleotides فلازم يكون كل ثلاثة
+
+408
+00:38:27,250 --> 00:38:31,370
+مع بعض يعني مش four nucleotides are used to
+
+409
+00:38:31,370 --> 00:38:35,670
+indicate the amino acid لازم three nucleotides are
+
+410
+00:38:35,670 --> 00:38:40,370
+used to indicate the amino acid نسميها triplets أو
+
+411
+00:38:40,370 --> 00:38:47,590
+الـ Codon فالـ
+
+412
+00:38:47,590 --> 00:38:55,030
+B هي الغلطماشي يعني عشان أغطي عشرين amino acid و
+
+413
+00:38:55,030 --> 00:38:59,050
+start و stop يعني او واحد عشرين amino acid أو
+
+414
+00:38:59,050 --> 00:39:02,970
+عشرين amino acid و ال start و ال stop هدولة صاروا
+
+415
+00:39:02,970 --> 00:39:09,430
+تلاتة و عشرين أو اتنين و عشرين message بديها أو
+
+416
+00:39:09,430 --> 00:39:19,110
+أقدر أحددها فاللي لازم يكون على أقل تلاتة basesلأ،
+
+417
+00:39:19,110 --> 00:39:24,170
+دي هي الـNucleotides لأنه أربعة أقصد ثلاث بيسووا
+
+418
+00:39:24,170 --> 00:39:30,930
+أربعة وستين يعني أربعة في أربعة في أربعة أربعة
+
+419
+00:39:30,930 --> 00:39:35,730
+وستين وأربعة وستين بتغطي العشرين طبعاً معناته إنه
+
+420
+00:39:35,730 --> 00:39:42,630
+بعض الـAmino Acids بيكون أكتر من Sequence بيغطيهم
+
+421
+00:39:42,630 --> 00:39:47,770
+يعني مش واحد لواحد تماماً ففيه جدوة اللي فرجتكم
+
+422
+00:39:47,770 --> 00:39:54,400
+اليومالجدول، خلّيني أدخل لـ «دكتور، بس given
+
+423
+00:39:54,400 --> 00:39:59,040
+الجدول، فيه سؤال، يعني فيه أسئلة بخصوص السؤال 12»
+
+424
+00:39:59,040 --> 00:40:04,860
+«12» «متعلق بقضية الـ stages أعتقد، في محمد بيقول
+
+425
+00:40:04,860 --> 00:40:09,100
+الـ Bromephase» «هو ليس لديه سينتروزومات، بدأت في
+
+426
+00:40:09,100 --> 00:40:17,880
+الـ Brometaphase» لأ، ال .. شو اسمه؟ سؤال رقم 12
+
+427
+00:40:21,490 --> 00:40:28,910
+بداية الـ Cell Division، ماشي؟ إحنا خلّينا الـ
+
+428
+00:40:28,910 --> 00:40:32,330
+Bromata Phase بيكون فيها Nuclear Membrane و لا
+
+429
+00:40:32,330 --> 00:40:38,670
+مافيش Nuclear Membrane؟ خلّيه يراجع الصورة، ماشي؟
+
+430
+00:40:38,670 --> 00:40:47,250
+يعني أنا السمرات إحنا لما نصف الحركات أو الـ Steps
+
+431
+00:40:47,840 --> 00:40:53,620
+يعني وجود الـ Centrosome تكوينه بتزامن تقريبًا
+
+432
+00:40:53,620 --> 00:40:58,260
+يمكن، ماعرفش، يعني ما بيقدرش الواحد يعني يحط حد
+
+433
+00:40:58,260 --> 00:41:04,840
+فاصل تمامًا بس الـ Prophase بالأول بيكون بداية
+
+434
+00:41:04,840 --> 00:41:11,280
+تكون يعني الـ Mitosis بعد ما الخلية دوبلت الـ DNA
+
+435
+00:41:11,280 --> 00:41:15,320
+تبعها يعني بالأول في الـ S-phase لما اتقررت، يعني
+
+436
+00:41:15,320 --> 00:41:20,130
+لما بدأت تقرر تنقسمبالأول بتكرر الـ DNA تبعها،
+
+437
+00:41:20,130 --> 00:41:25,790
+الجهد بعدين تبدأ تشتغل، فتدخل بالـ Pro-phase لما
+
+438
+00:41:25,790 --> 00:41:29,350
+يكون لسه فيه Nuclear Membrane الوحيد اللي في الصور
+
+439
+00:41:29,350 --> 00:41:31,770
+كلها اللي فيها Nuclear Membrane هو الـ Pro-phase
+
+440
+00:41:31,770 --> 00:41:37,750
+الـ Pro-metaphase والـ Metaphase، لأ مافيش Nuclear
+
+441
+00:41:37,750 --> 00:41:41,270
+Membrane فاختفاء الـ Nuclear Membrane أنا أخدته
+
+442
+00:41:41,270 --> 00:41:45,710
+إنه الـ Pro-metaphase ف… وبيبدأ من أول شيء يتشكل
+
+443
+00:41:45,710 --> 00:41:54,470
+الـ Centrosomeيعني هسا اللي خدها أقوى يعني بالنسبة
+
+444
+00:41:54,470 --> 00:41:59,990
+للـ «نوكليار ممبرين» اللي هو إنه طبعاً بالـ
+
+445
+00:41:59,990 --> 00:42:06,630
+«بروفيس» بكون لسه موجود ماشي، اتطلع الصورة وشوفها،
+
+446
+00:42:06,630 --> 00:42:07,490
+ماشي
+
+447
+00:42:11,980 --> 00:42:20,220
+بتكم ناخذ اللي هي Human Genome خلّيني بس أفرج،
+
+448
+00:42:20,220 --> 00:42:26,880
+أطلّع الصورة تبعتها هاي
+
+449
+00:42:26,880 --> 00:42:30,180
+وبعدين،
+
+450
+00:42:30,180 --> 00:42:34,640
+هاي، ثواني خلّيني أسوي لكم share بعد شوية بس،
+
+451
+00:42:34,640 --> 00:42:45,460
+ثواني على الـ… هايطيب، هاي هونا الـ Genetic
+
+452
+00:42:45,460 --> 00:42:52,820
+Diversity نعم،
+
+453
+00:42:52,820 --> 00:43:00,980
+مش هذه هاي
+
+454
+00:43:00,980 --> 00:43:04,480
+طبعاً Psychogenetics
+
+455
+00:43:15,530 --> 00:43:23,570
+وين راحت مش شايف الصورة هسه لو أنا human genome
+
+456
+00:43:55,820 --> 00:44:07,780
+أخر مرة أشوف هذه سبحان
+
+457
+00:44:07,780 --> 00:44:15,180
+الله كيف لما بدك إشي ما بتلاقيهوش المهم ارجع للـ
+
+458
+00:44:15,180 --> 00:44:25,180
+بالنسبة لـالترتيب هذا، اتطلع على الصورة ويعني أنا
+
+459
+00:44:25,180 --> 00:44:33,020
+أظن الكلام واضح بالنسبة لـ الـ الكلام واضح بالنسبة
+
+460
+00:44:33,020 --> 00:44:39,700
+لـ الـ Stage اللي هي يعني ركز على موضوع اللي هو
+
+461
+00:44:39,700 --> 00:44:44,400
+وجود الـ Cell Membrane مش عارف عليه؟ آسف الـ
+
+462
+00:44:44,400 --> 00:44:47,650
+Nuclear Membraneالـ Stage الوحيد اللي فيها Nuclear
+
+463
+00:44:47,650 --> 00:44:56,230
+Membrane هي الـ Prophase الـ بالنسبة لـ الآن
+
+464
+00:44:56,230 --> 00:45:07,270
+السؤال على الـ اللي هو أظن 1917 بالكوانين الآن
+
+465
+00:45:07,270 --> 00:45:16,360
+بس بنذبحكم على شغل بالنسبة لسؤال 19 ماشييعني
+
+466
+00:45:16,360 --> 00:45:26,020
+بالنسبة هنا هاي الـShare بالنسبة
+
+467
+00:45:26,020 --> 00:45:29,860
+لترتيب الـ…
+
+468
+00:45:29,860 --> 00:45:36,460
+بالنسبة لترتيب الـ… إنه Amino Acids وTriplets كيف؟
+
+469
+00:45:36,460 --> 00:45:41,940
+وAnode coding for what؟ وكده فبدأ أطلب منكم
+
+470
+00:45:41,940 --> 00:45:52,860
+تتذكروا شغلة اللي هيصراحة لقيتها في USMLE
+
+471
+00:45:52,860 --> 00:46:00,960
+وغيره الآن هذه الجدول اللي احنا شوفناها والـ First
+
+472
+00:46:00,960 --> 00:46:06,480
+Base هي الـ U وC وA وG وهذه الـ Second Base اللي
+
+473
+00:46:06,480 --> 00:46:16,020
+هي الـ U وC وA وG وهذه الـ Third Base هنا فكل
+
+474
+00:46:16,020 --> 00:46:20,500
+ثلاثية هو أنا بعطيكم شو الـ Amino Acid تبعها
+
+475
+00:46:20,500 --> 00:46:27,800
+فالفنع الأنالين الـ UUU أو UUC مثلا، يمكن يكون في
+
+476
+00:46:27,800 --> 00:46:34,900
+غيرهم، ماشي؟ الأشياء اللي لاحظته مركزين عليه ويله
+
+477
+00:46:34,900 --> 00:46:36,420
+تأثير في
+
+478
+00:46:38,900 --> 00:46:43,940
+يعني له تأثير في قضية بعض الحالات وبعض الأمراض
+
+479
+00:46:43,940 --> 00:46:50,580
+اللي حطينا اللي هو الـ «UAA»
+
+480
+00:46:50,580 --> 00:46:55,020
+و «UAG» أنا ماكنتش حافظهم أو عمري ماحفظتهم أيه بس
+
+481
+00:46:55,020 --> 00:47:00,900
+مش غلط الواحد يتذكر «UAA» أو «UAG» هاي الـ «Stock
+
+482
+00:47:00,900 --> 00:47:10,770
+Codon» و «UGA» هاي تلافة ماشيهدولة ثلاثة sequences
+
+483
+00:47:10,770 --> 00:47:19,470
+بتاعني stop ماشي فهدولة لما ييجيوكم مش عارف كيف
+
+484
+00:47:19,470 --> 00:47:28,050
+الواحد يحفظها UAA UGA UAG يعني هدولة أولها U
+
+485
+00:47:28,050 --> 00:47:34,450
+وآخرها G وA هدولة بمعنى stopلما يحكوا لك ويديبوا
+
+486
+00:47:34,450 --> 00:47:42,610
+لك قصة وفيه سؤال جبته إنه فيه بالأخير خلل فيه إنه
+
+487
+00:47:42,610 --> 00:47:47,130
+صار إشي بدل إشي بحيث إنه اتكونت واحدة من هدولة
+
+488
+00:47:47,130 --> 00:47:55,090
+التلاتة بتخلي إنه يصير عند الحالة بيصير يعني بيصير
+
+489
+00:47:55,090 --> 00:47:58,510
+stop
+
+490
+00:47:58,510 --> 00:48:04,540
+reading of theالبروتين أو التكوين للبروتين بيوقف
+
+491
+00:48:04,540 --> 00:48:12,880
+في مرحلة مش طبيعية فهي ناحية مهمة بس خلّيني أشوف
+
+492
+00:48:12,880 --> 00:48:25,200
+وين راحت هذه الصورة فالآن
+
+493
+00:48:25,200 --> 00:48:30,970
+بالنسبة للسؤال اللي سألوا زميلكميعني احنا المهم
+
+494
+00:48:30,970 --> 00:48:37,730
+بدل واحد يتذكر فيه P-MAT أو P-MAT فالـ Chrome
+
+495
+00:48:37,730 --> 00:48:42,570
+الصورة هنا الـ Prophets فيه Nuclear Membrane هي
+
+496
+00:48:42,570 --> 00:48:46,890
+الوحيد اللي فيها Nuclear Membrane لسه ما اتحطمش
+
+497
+00:48:46,890 --> 00:48:51,810
+بعد ما كثرت الـ DNA تبعها والـ Central Zones هي
+
+498
+00:48:51,810 --> 00:49:00,830
+الموجودينفالسؤال الأتناش، شو اسمه؟ السؤال الأتناش
+
+499
+00:49:00,830 --> 00:49:09,370
+صحيح ويعني هي الموجودة، ماشي الـ
+
+500
+00:49:09,370 --> 00:49:16,490
+Epigenetic Mechanisms main point إنه they are
+
+501
+00:49:16,490 --> 00:49:21,710
+difficult to understand and difficult to studyيعني
+
+502
+00:49:21,710 --> 00:49:27,570
+الـ Mechanisms تبعتها للآن ما استقر الإلم عليها
+
+503
+00:49:27,570 --> 00:49:36,190
+بشكل واضح، كامل، مبسط، سهل، كده They are needed to
+
+504
+00:49:36,190 --> 00:49:40,390
+control which genes are activated in each type of
+
+505
+00:49:40,390 --> 00:49:47,310
+cell، صحيح كل الجينات تبعت كل الخلايا في جسم
+
+506
+00:49:47,310 --> 00:49:52,190
+الإنسان زي بعض اللي بيفرق خلية عن خليةأنه الجين
+
+507
+00:49:52,190 --> 00:49:56,230
+اللي اشتغل في هذه الكلمة؟ كيف هذا الجين بيشتغل أو
+
+508
+00:49:56,230 --> 00:50:00,850
+مابيشتغلش؟ هذا الـ Epigenetic Mechanism فهي صعبة
+
+509
+00:50:00,850 --> 00:50:07,150
+تدرس و تفهمها الـ Genetic Imprinting أو الـ
+
+510
+00:50:07,150 --> 00:50:11,230
+Parental Imprinting هذا والله للآن ماني فاهمه،
+
+511
+00:50:11,230 --> 00:50:15,530
+ماشي؟ بس هو Epigenetic Mechanism يصير عندنا DNA
+
+512
+00:50:15,530 --> 00:50:20,280
+Mutilation Testosterone Variation وMutilationوالـ
+
+513
+00:50:20,280 --> 00:50:25,200
+Genetic Imprinting كلهم ميكانيزم للـ Epigenetic
+
+514
+00:50:25,200 --> 00:50:30,260
+Mechanism اللي هما يعني مش في الـ Coding DNA هدولة
+
+515
+00:50:30,260 --> 00:50:34,900
+في الـ Controlling DNA أو Controlling Mechanism
+
+516
+00:50:34,900 --> 00:50:42,060
+للـ Expression ماشي، في أسئلة؟
+
+517
+00:50:42,060 --> 00:50:45,360
+الآن في موضوع اتكلمنا عنه اسمه الـ Allelic
+
+518
+00:50:45,360 --> 00:50:53,220
+Expression اللي هو أنهالذي يتم إظهاره الأليل وإذا
+
+519
+00:50:53,220 --> 00:50:57,400
+كان هناك إثنين أليل فهو يجب أن يتم إظهاره الأليل
+
+520
+00:50:57,400 --> 00:51:03,720
+أحياناً تكون جينات معينة أن كلا الأليل تم إظهارهم
+
+521
+00:51:03,720 --> 00:51:09,300
+بشكل متساوي صحيح في أحيان بيحصل اسمه أشياء أليلة
+
+522
+00:51:09,300 --> 00:51:12,580
+في الانفجار يعني يكون عنده أشياء مختلفة
+
+523
+00:51:25,250 --> 00:51:30,310
+الخيار الأول كأنه بيقول ان ال expression خمسين
+
+524
+00:51:30,310 --> 00:51:34,850
+خمسين بالنية الخيار الثاني صفر ومية
+
+525
+00:51:37,460 --> 00:51:41,260
+أحيانًا ما بتكون في هالـ Two extremes خمسين وخمسين
+
+526
+00:51:41,260 --> 00:51:46,200
+أو صفر ومية مرات سبعين وثلاثين، ستين واربعين
+
+527
+00:51:46,200 --> 00:51:50,580
+مثلًا، فابدى أسموه Unbalanced expression which
+
+528
+00:51:50,580 --> 00:51:54,920
+occurs in early embryogenesis صحيحة، in females
+
+529
+00:51:54,920 --> 00:51:58,520
+الـ X chromosome inactivation randomly occurs
+
+530
+00:51:58,520 --> 00:52:03,640
+صحيح، وSomatic mutations which is a cause of
+
+531
+00:52:03,640 --> 00:52:10,320
+allylic expression variation برضه صحيحةبالنسبة للـ
+
+532
+00:52:10,320 --> 00:52:16,760
+Mutations لما ندرس الـ Genome الـ Most Common في
+
+533
+00:52:16,760 --> 00:52:23,520
+أي خلية تقريبًا عن الـ Standard بيكون حوالي 5 إلى
+
+534
+00:52:23,520 --> 00:52:28,980
+10 مليون اللي هم Single Nucleotide Polymorphism
+
+535
+00:52:28,980 --> 00:52:34,040
+هدولة لما نسيروا ما بيقدّوا لهذا الشيء مرات كثيرة
+
+536
+00:52:34,040 --> 00:52:39,080
+خصوصًا إنه ممكن هذا يحدث في منطقة Non-codingيعني
+
+537
+00:52:39,080 --> 00:52:45,180
+ما لهاش قيمة يعني في بعضهم في عندنا Frame Shift
+
+538
+00:52:45,180 --> 00:52:50,000
+Type Deletion Type Inversion Type Copy Number
+
+539
+00:52:50,000 --> 00:52:55,260
+Variation Type هدولة Different Forms of Variation
+
+540
+00:52:55,260 --> 00:52:59,680
+بس أقوى أشي أكتر أشي حدوثًا اللي هو Single
+
+541
+00:52:59,680 --> 00:53:06,960
+Nucleotide Polymorphism الآن إذا صار عندي Deletion
+
+542
+00:53:06,960 --> 00:53:13,940
+أو Insertionإذا ثلاثات أو مضاعفاتها ما لها قيمة
+
+543
+00:53:13,940 --> 00:53:18,400
+كبيرة ما بيأثر كثير على البروتين النهائي بس لما
+
+544
+00:53:18,400 --> 00:53:21,700
+يصير عندي deletion أو insertion لـ one أو two
+
+545
+00:53:21,700 --> 00:53:28,960
+nucleotides هذا هو المشكلة إذا ثلاثة يعني بضيف
+
+546
+00:53:28,960 --> 00:53:35,220
+amino acid ففي الغالب البروتين بتحمل وممكن يكون
+
+547
+00:53:35,220 --> 00:53:45,500
+يعني في منطقة مش مؤثرة ماشيف6 و0 و3 ومضاعفاتها ما
+
+548
+00:53:45,500 --> 00:53:54,420
+في مشكلة بس 1 و2 هي اللي فيها المشكلة ماشي الحال؟
+
+549
+00:53:54,420 --> 00:54:01,500
+لما ندرس الـ Single-Newt Cleotide Polymorphism
+
+550
+00:54:01,500 --> 00:54:08,020
+يعني خلّينا نتذكر كلمةلما أريد أن أدرس كـ
+
+551
+00:54:08,020 --> 00:54:14,240
+Chromosome، Anomaly، Turner-Klein Filter، كذا،
+
+552
+00:54:14,240 --> 00:54:19,920
+تعمل شيء يسمونه كـ Karyotype لما أريد أن أدرس على
+
+553
+00:54:19,920 --> 00:54:24,420
+Single Nucleotide Polymorphism لازم أعمل Sequence
+
+554
+00:54:24,420 --> 00:54:30,360
+with PCR Reaction ماشي، Polymerase Chain Reaction
+
+555
+00:54:30,360 --> 00:54:37,650
+فهذه الـالـ «سيجمان»
+
+556
+00:54:37,650 --> 00:54:45,330
+فيها غلط بالكتابة، ماشي الـ sequencing of the DNA
+
+557
+00:54:45,330 --> 00:54:51,330
+الـ «BF» غلط، مش مفروض يكون هناك، ظهر بالتباعة
+
+558
+00:54:51,330 --> 00:54:58,270
+يعني الكاريوتيب ما بيظبط فيكي، بدرسش كبير الـ
+
+559
+00:54:58,270 --> 00:55:05,000
+Fluorescentوالـ Microsatellites
+
+560
+00:55:05,000 --> 00:55:12,700
+وحتى الـ Routine Banding ماشي هدولة مثلا زي Dijard
+
+561
+00:55:12,700 --> 00:55:17,800
+Syndrome زي يعني بيكون فيها segment كبير ما بيكون
+
+562
+00:55:17,800 --> 00:55:25,680
+تقدر تكشفني على Single Nucleotide Polymerism آه،
+
+563
+00:55:25,680 --> 00:55:31,910
+في سؤال؟ في سؤال منمهم في سؤال بيقول ليش ما عملنا
+
+564
+00:55:31,910 --> 00:55:36,670
+الـ FISH الـ Fluorescent and Cytohybridization ال
+
+565
+00:55:36,670 --> 00:55:45,910
+.. شوف سؤال 24 آه ما هو 24 خيار C لأ احنا الـ FISH
+
+566
+00:55:45,910 --> 00:55:55,170
+أنا طريقته اني انا بحط قطعة بتكون مثلا عشرة عشرين
+
+567
+00:55:55,170 --> 00:56:00,400
+ثلاثين اربعين ماعرفش كده يعني بالضبط مية بالميةمن
+
+568
+00:56:00,400 --> 00:56:07,300
+الـ «DNA Nucleotides» ماشي بحط ترتيب معين لحيث أنه
+
+569
+00:56:07,300 --> 00:56:12,460
+يعني شوف إذا اتخيلنا بطلب من الكل دائما هيك يفكر
+
+570
+00:56:12,460 --> 00:56:18,000
+فيها تتذكرها وكده لما نتكلم عن Single Nucleotide
+
+571
+00:56:18,000 --> 00:56:23,820
+إذا اتخيلنا البروتين قلنا مثال بالأول البروتين هو
+
+572
+00:56:23,820 --> 00:56:33,680
+عبارة عن قصيدة شعر ماشيلما أنا بدي أدور على اختلاف
+
+573
+00:56:33,680 --> 00:56:40,560
+حرف لازم أستخدم تقنية مختلفة عامة من اللي بدي أدور
+
+574
+00:56:40,560 --> 00:56:45,920
+إذا فيه اختلاف بيت معين أو Shutterbait يعني لما
+
+575
+00:56:45,920 --> 00:56:51,060
+أنا بستخدم الـFish والـMicrosatellite
+
+576
+00:56:51,060 --> 00:56:56,540
+Array Test ودولة الـKaryotyping بدور على الكرمزون
+
+577
+00:56:56,540 --> 00:57:02,510
+كله، ماشي؟وما باستحيل يفرجيني الـ Chromosome كله
+
+578
+00:57:02,510 --> 00:57:06,790
+الـ Single Nucleotide Polymorphism الـ Fluorescent
+
+579
+00:57:06,790 --> 00:57:11,230
+Encyto-Hybridization والـ Micro Satellite Array
+
+580
+00:57:11,230 --> 00:57:17,470
+بدك تحط الـ Segment of Interest لازم تكون كبير
+
+581
+00:57:17,470 --> 00:57:24,150
+شوية حتى إنه يقدر يكون فيه تفابق بين قطعتين مع بعض
+
+582
+00:57:24,570 --> 00:57:28,730
+يعني زي كأنك بتعمل Google search بتحف على شطر
+
+583
+00:57:28,730 --> 00:57:33,530
+القصيدة وبتشوف أني قصيدة قالوا فيها هالكلام مثلا
+
+584
+00:57:33,530 --> 00:57:39,770
+وقوفا بها صاحبي عليا مطيهم يقولوا للا تهلك أسن
+
+585
+00:57:39,770 --> 00:57:44,190
+وتجلد في هدولة في على الأقل شاعرين في الجهلية
+
+586
+00:57:44,190 --> 00:57:50,850
+قالوها فوقوفا بها صاحبي بقول هذه القطعة هي المميز
+
+587
+00:57:50,850 --> 00:57:57,330
+اللي أنا بدي إياها بجيببرنامج كمبيوتر زي جوجل في
+
+588
+00:57:57,330 --> 00:58:02,970
+كل قصاد الشعر في الدنيا وبزدت عليها وبدور مين حكى
+
+589
+00:58:02,970 --> 00:58:08,910
+مثل هذا البيت ماشي هيك هذولة fish و micro
+
+590
+00:58:08,910 --> 00:58:13,570
+-satellite array بس عشان أدقق إنه في حرف اختلف بين
+
+591
+00:58:13,570 --> 00:58:19,890
+حرف بين قصيدة وقصيدة تانية في مكان معين في شخص
+
+592
+00:58:19,890 --> 00:58:24,370
+معين أو كذا بدي أعمل polymerase chain reactionوالـ
+
+593
+00:58:24,370 --> 00:58:27,410
+Sequencing ما راح يديب ليها إلا الـ Sequencing
+
+594
+00:58:27,410 --> 00:58:33,210
+ماشي، يعني الـ Sequencing بتطلقلي براءة أحرف الـ
+
+595
+00:58:33,210 --> 00:58:39,370
+Nucleotides تبعات الـ ال DNA هذا عند هذا الإنسان
+
+596
+00:58:39,370 --> 00:58:45,290
+فلمّا نبدأ أدور على SNP Staining الـ Nucleotides
+
+597
+00:58:45,290 --> 00:58:49,910
+Polymorphism اللي اسمها SNP لازم أعمل Sequencing و
+
+598
+00:58:49,910 --> 00:58:50,370
+PCR
+
+599
+00:58:55,020 --> 00:59:01,240
+25 و26 من جدول straightforward الـ Abbreviations
+
+600
+00:59:01,240 --> 00:59:05,440
+لازم واحد يعرفها الـ Marker Chromosome اللي هو الـ
+
+601
+00:59:05,440 --> 00:59:10,460
+MAR يعني لما نستخدم الـ Fish والـ Microsatellite
+
+602
+00:59:10,460 --> 00:59:14,560
+الـ Math هو الـ Maternal Chromosome عكس الـ
+
+603
+00:59:14,560 --> 00:59:17,860
+Paternal Chromosome يعني الـ Chromosome نسخة من
+
+604
+00:59:17,860 --> 00:59:24,680
+الأم مش من الأب ماشي الـ Maternal فهذه واحدةلما
+
+605
+00:59:24,680 --> 00:59:30,760
+يحطوا Abbreviation يكون فيها بالأخير Positive فيه
+
+606
+00:59:30,760 --> 00:59:34,480
+Gain of function بعض الـ Diseases يا إما Loss أو
+
+607
+00:59:34,480 --> 00:59:38,460
+Gain of function وفيه Translocation الـT والـP
+
+608
+00:59:38,460 --> 00:59:41,900
+والـQ والـShort والـLong، أعرف هدولة Standard
+
+609
+00:59:41,900 --> 00:59:47,240
+Abbreviation يعني أنا بعتقد عشان الواحد بعدين في
+
+610
+00:59:47,240 --> 00:59:51,880
+حياته لما يقرأ النتائج
+
+611
+00:59:54,460 --> 00:59:59,380
+يكون متذكر هدول الـ abbreviation مهمات يعني أنا ب
+
+612
+00:59:59,380 --> 01:00:05,440
+.. كويس الواحد يتذكرها الـ Communist Mechanism of
+
+613
+01:00:05,440 --> 01:00:08,980
+Down Syndrome اللي هو associated with high
+
+614
+01:00:08,980 --> 01:00:13,300
+maternal age اللي هو non-disjunction in meiosis
+
+615
+01:00:13,300 --> 01:00:19,440
+هذه الإجابة الصحيحة في سؤال من دكتور بتقول في ممكن
+
+616
+01:00:19,440 --> 01:00:23,180
+توضيح أكثر لسؤال 21 اللي هو إيش؟
+
+617
+01:00:29,840 --> 01:00:35,700
+بس إنسان إنسان
+
+618
+01:00:35,700 --> 01:00:43,860
+عنده مثلًا Two chromosomes ناخد مثلًا الـ Blood
+
+619
+01:00:43,860 --> 01:00:52,980
+Group AB-Osystem ماشي الآن اللي عنده Group AB عنده
+
+620
+01:00:52,980 --> 01:00:57,580
+Two chromosomes which are أو عنده Two alleles
+
+621
+01:00:57,580 --> 01:01:03,000
+which are differentباعطونا Different Proteins اللي
+
+622
+01:01:03,000 --> 01:01:09,540
+هم الـ A و الـ B الإنسان العادي أو اللي بيصير في
+
+623
+01:01:09,540 --> 01:01:14,180
+الخلية العادية اللي كانت Red Blood Cell راح تصير
+
+624
+01:01:14,180 --> 01:01:19,660
+Red Blood Cell في الـ Development تبع الـ Red
+
+625
+01:01:19,660 --> 01:01:24,900
+Blood Cell اللي عنده AB على كل خلية بظهر الـ A و
+
+626
+01:01:24,900 --> 01:01:31,340
+بظهر الـ B بنفس الدرجة فهدولةبتكون equal
+
+627
+01:01:31,340 --> 01:01:38,080
+expression of the two alleles هاي ظاهرة بتحدث في
+
+628
+01:01:38,080 --> 01:01:42,560
+بعض الخلايا، في بعض الأليل وبالنسبة للي بيسموها
+
+629
+01:01:42,560 --> 01:01:47,260
+Allelic Expression Level ماشي، فيها slide شرحناها
+
+630
+01:01:47,260 --> 01:01:55,720
+من قبل فالآن، هاي ظاهرة بتحدث بس كمان بتحدث إنه
+
+631
+01:01:55,720 --> 01:01:59,940
+بيكون إنهيعني هنا بدنا نعتبر الـ Expression في هذه
+
+632
+01:01:59,940 --> 01:02:05,680
+الخلية لهذه الـ Two Alleles fifty-fifty خمسين
+
+633
+01:02:05,680 --> 01:02:10,560
+خمسين، قط بعض أحياناً في بعض الخلايا التانية أو
+
+634
+01:02:10,560 --> 01:02:15,260
+البروتينات التانية أو الأوضاع التانية بنلاقي الـ
+
+635
+01:02:15,260 --> 01:02:21,320
+Expression مية صفر يعني هو عنده Two Alleles ماشي
+
+636
+01:02:21,320 --> 01:02:29,620
+في هذه الخلية الـA مية والـB صفرخلية ثانية الـ B
+
+637
+01:02:29,620 --> 01:02:35,060
+صفر الـ B100 والـ A صفر ماشي ففي اللي هنا بدنا
+
+638
+01:02:35,060 --> 01:02:39,060
+نسميه اسمه الـ Allelic Exclusion يعني في كل خلية
+
+639
+01:02:39,060 --> 01:02:46,780
+القليل اللي بيشتغل بمنع القليل التاني يتكوّن واضح؟
+
+640
+01:02:46,780 --> 01:02:53,260
+فهي بنسميه اللي هو Allelic Exclusion يعني ما بيصير
+
+641
+01:02:53,260 --> 01:02:58,860
+نفس الخلية تتطلعنوعين مختلفين من الـA والـB بتطلع
+
+642
+01:02:58,860 --> 01:03:04,440
+يا A يا B هاي أحياناً بحده وأحياناً fifty-fifty في
+
+643
+01:03:04,440 --> 01:03:08,880
+نفس الخلية برضه بحده ومرات Unbalanced Expression
+
+644
+01:03:08,880 --> 01:03:15,100
+برضه بحده ماشي الـLionization اللي هو for X
+
+645
+01:03:15,100 --> 01:03:20,680
+-Chromosome deactivation هو Allelic Exclusion يعني
+
+646
+01:03:20,680 --> 01:03:26,150
+في كل خليةيا هذا الـ X-Chromosome شغال من الأبو
+
+647
+01:03:26,150 --> 01:03:29,910
+الـ X-Chromosome تبع الأب يا إما الـ X-Chromosome
+
+648
+01:03:29,910 --> 01:03:34,150
+تبع الأم يكون شغال في الخلية الواحدة بس في جسم
+
+649
+01:03:34,150 --> 01:03:43,330
+الإنسان يعني قد يكون نص بالنص، ربع بالتلترباع،
+
+650
+01:03:43,330 --> 01:03:49,650
+أنايت، يعني بس النوعين موجودة فاهمي علي؟ فأحيانًا
+
+651
+01:03:49,650 --> 01:03:55,650
+الـ يعني هي الـ Early Embryogenesisتضطر الخلايا
+
+652
+01:03:55,650 --> 01:04:02,390
+إنه تقرر أنه واحد منهم بدي يشتغل وفي كل نواتج هذه
+
+653
+01:04:02,390 --> 01:04:07,390
+الخلايا إذا قررت إن هذا الـChromosome أو هذا
+
+654
+01:04:07,390 --> 01:04:13,190
+الأليل اللي بدي يشتغل هو بيظلها عليه، بتجلبش على
+
+655
+01:04:13,190 --> 01:04:18,430
+النوع التاني إن شاء الله إنه واضح، إذا في تحديد
+
+656
+01:04:18,430 --> 01:04:21,890
+أكبر لإيش اللي مش واضح، تحكيليه
+
+657
+01:04:30,120 --> 01:04:35,440
+بالنسبة لـ Chromosomal Anomaly Not Compatible With
+
+658
+01:04:35,440 --> 01:04:41,180
+Live Birth الـ Triploid و التترابلويد هذه مش
+
+659
+01:04:41,180 --> 01:04:46,200
+compatible، ما في إنا إيه يعني الـ Triploid و
+
+660
+01:04:46,200 --> 01:04:52,860
+التترابلويد في النباتات شائعة جدا يعني إحنا في
+
+661
+01:04:52,860 --> 01:05:00,730
+خلايانا كلها 2MالـEgg والـSperm 1N في الـCell
+
+662
+01:05:00,730 --> 01:05:05,830
+Division فليه لما تنقسم أو في الـCancer ممكن نلاقي
+
+663
+01:05:05,830 --> 01:05:16,090
+4N، 5N، 6N يكون أو 6N يعني تطلع تـTriploid، ناشي؟
+
+664
+01:05:16,090 --> 01:05:22,870
+لما نقول Ploid لكل الجينوم، لكل الكرمزومات، ناشي؟
+
+665
+01:05:22,870 --> 01:05:30,830
+فهذه لما تتـ .. يعني يصيربشكل ما مثلا بدل ما يعني
+
+666
+01:05:30,830 --> 01:05:38,070
+الخلية تيجي تنقسم في حالة الـSperm أو الـEgg ومثلا
+
+667
+01:05:38,070 --> 01:05:42,930
+الـCentromere يفشل الـCentrosome يفشل وكل الـTwo
+
+668
+01:05:42,930 --> 01:05:48,310
+copies يروح في جهة واحدة فبالتالي الـSperm أو
+
+669
+01:05:48,310 --> 01:05:52,190
+الـEgg راح يكون فيه Two N مش One N فلما تصير
+
+670
+01:05:52,190 --> 01:05:59,460
+التلقيح بيصير Three N أوممكن يصير 4M فهذه لما تحدث
+
+671
+01:05:59,460 --> 01:06:06,640
+هذا فاشل نهائيًا لا يمكن يكمل البقية تحدث ممكن
+
+672
+01:06:06,640 --> 01:06:12,400
+يوصل الـ Down Syndrome تحدث الـ Super Female XXX
+
+673
+01:06:12,400 --> 01:06:17,120
+تحدث الـ Balance Rearrangement في الأب نفسه أو
+
+674
+01:06:17,120 --> 01:06:23,150
+الأمبكون إذا حدثت مظبوط والـ XYY برضه بتحدث هدولة
+
+675
+01:06:23,150 --> 01:06:31,290
+مش incompatible with lifestyle ناشي؟ الـ Most
+
+676
+01:06:31,290 --> 01:06:34,210
+Important Risk Factor for the occurrence of
+
+677
+01:06:34,210 --> 01:06:37,790
+Trisomy 21 اللي هو الـ Increasing Maternal Age الـ
+
+678
+01:06:37,790 --> 01:06:41,450
+Smoking، الـ Mumps، الـ Exposure، الـ Radiation
+
+679
+01:06:41,450 --> 01:06:46,030
+جرمن نيزل، هدولة كلهم بيعملوا مشاكل تانية بس مش
+
+680
+01:06:46,030 --> 01:06:51,810
+الـ Down SyndromeالـExample of chromosomal segment
+
+681
+01:06:51,810 --> 01:06:59,670
+اللي هي الـshort arm الـP11 short arm of the
+
+682
+01:06:59,670 --> 01:07:06,110
+chromosome 22 أو 21 اللي هو Diehard Syndrome
+
+683
+01:07:06,110 --> 01:07:12,750
+الأكندروبلازيا Single mutation of chromosomal
+
+684
+01:07:12,750 --> 01:07:18,450
+dominant الـBronchial asthma بوليجينيةالهيموفيليا
+
+685
+01:07:18,450 --> 01:07:25,670
+A وB عبارة عن Single Gene والـ Clam Filter مش
+
+686
+01:07:25,670 --> 01:07:30,650
+كرومزوم، سيجمند، كرومزوم كامل، بيبقى Problem فده
+
+687
+01:07:30,650 --> 01:07:40,210
+الـ George's Syndrome الصحيح فالـ 31 What's
+
+688
+01:07:40,210 --> 01:07:44,630
+the main driving force for normal for female sex
+
+689
+01:07:45,150 --> 01:07:48,950
+الـ Development هي الـ Default وعدم وجود الـ Y
+
+690
+01:07:48,950 --> 01:07:56,410
+-Chromosome اللي بيخلّي الإنسان يصير Female إنه
+
+691
+01:07:56,410 --> 01:08:02,370
+مافيش Y-Chromosome أو مش شغال و
+
+692
+01:08:02,370 --> 01:08:09,440
+الـ Inactive X-Chromosome اللي هو الـ Bar Bodyالـ
+
+693
+01:08:09,440 --> 01:08:14,260
+Communist Sex Chromosome الـ «أنوميلي» الميل في
+
+694
+01:08:14,260 --> 01:08:22,680
+الـ «تينوتيب» الـ «Kleinfilter» اللي هو XYY لما
+
+695
+01:08:22,680 --> 01:08:26,560
+يكون في عندي Double Lines بالنسبة للـ Pedigree
+
+696
+01:08:26,560 --> 01:08:32,920
+اللي هو إن وجود Consanguinity لما نحط Double Lines
+
+697
+01:08:32,920 --> 01:08:38,690
+ماشي، الـ Horizontal Linesالـ Probant بيحطوه هيك
+
+698
+01:08:38,690 --> 01:08:45,290
+سهل الـ twins identical و not identical دو ال male
+
+699
+01:08:45,290 --> 01:08:51,430
+و female سيمبل الدائرة و المربع و كده و هيك main
+
+700
+01:08:51,430 --> 01:08:55,250
+second degree relative ال parents و ال brothers و
+
+701
+01:08:55,250 --> 01:08:59,810
+ال children ا first degree ال parents و ال
+
+702
+01:08:59,810 --> 01:09:05,270
+brothers و ال children ال spouse الأصل بعيد الأصل
+
+703
+01:09:06,420 --> 01:09:13,120
+الـ Second degree relative، الـ Grandparents الآن،
+
+704
+01:09:13,120 --> 01:09:18,920
+الـ Disease transmitted on maternal line only الـ
+
+705
+01:09:18,920 --> 01:09:22,060
+Females transmit the disease to their children،
+
+706
+01:09:22,060 --> 01:09:25,700
+both males and females and affected males do not
+
+707
+01:09:25,700 --> 01:09:27,900
+transmit the disease، الـ Definition تبع
+
+708
+01:09:27,900 --> 01:09:35,770
+الميتيكودريالية، حكينا السبب من قبلهذا سؤال اللي
+
+709
+01:09:35,770 --> 01:09:41,270
+هو Single gene disease that affects male المفروض
+
+710
+01:09:41,270 --> 01:09:45,930
+كان حطيت كومة والـ females are normal carriers
+
+711
+01:09:45,930 --> 01:09:50,690
+اللي هو X-linked recesses الناس قالوها جملة واحدة
+
+712
+01:09:50,690 --> 01:09:56,270
+affects males and females لأ طيب
+
+713
+01:10:00,200 --> 01:10:04,320
+بالنسبة لسؤال 38 regarding the frequencies of
+
+714
+01:10:04,320 --> 01:10:07,120
+different types of genetic disorders in different
+
+715
+01:10:07,120 --> 01:10:16,820
+stages of life، All statements، نتذكر إنه الأول،
+
+716
+01:10:16,820 --> 01:10:23,480
+نسبة أو احتمالية حدوث سواء single gene أو
+
+717
+01:10:23,480 --> 01:10:30,440
+chromosomal disorders much higherواللي بيظل عند
+
+718
+01:10:30,440 --> 01:10:35,360
+الإنسان لما يكون كبير بالعمر أو كان يكبر بالعمر أو
+
+719
+01:10:35,360 --> 01:10:37,880
+الـ General population بتكون Multifactorial
+
+720
+01:10:37,880 --> 01:10:42,460
+Diseases فالـ Frequencies of single gene disorders
+
+721
+01:10:42,460 --> 01:10:47,760
+are rarer، less frequent than genome اللي هو
+
+722
+01:10:47,760 --> 01:10:52,300
+Multifactorial or Chromosomal disorders and all
+
+723
+01:10:52,300 --> 01:10:56,120
+stages هاي غلط
+
+724
+01:10:57,720 --> 01:11:04,640
+Multifactorial في الأول صحيح هما لسه الـMost
+
+725
+01:11:04,640 --> 01:11:09,460
+Frequent بس يعني إذا بتشوف الصورة مثلا عشرة Single
+
+726
+01:11:09,460 --> 01:11:14,680
+Gene وخمسين Multifactorial بعدها بيصير الـSingle
+
+727
+01:11:14,680 --> 01:11:19,880
+Gene مثلا عشرين على الـGeneral Population
+
+728
+01:11:19,880 --> 01:11:23,240
+والـMultifactorial 600 بصورة ده بيصير عددهم كبير
+
+729
+01:11:23,240 --> 01:11:27,770
+كتيرالـ Single Gene and Genome and Chromosome الـ
+
+730
+01:11:27,770 --> 01:11:31,070
+Single Gene and Genome and Chromosome الـ
+
+731
+01:11:31,070 --> 01:11:35,090
+disorders are more frequent at birth صحيح؟ إذا في
+
+732
+01:11:35,090 --> 01:11:40,370
+Single Gene وChromosomal disorders at birth الـ
+
+733
+01:11:40,370 --> 01:11:43,070
+Multifactorial disorders increasing prevalence و
+
+734
+01:11:43,070 --> 01:11:46,310
+decreasing age in general population صحيح؟ وفي
+
+735
+01:11:46,310 --> 01:11:50,630
+حوالي 600 Multifactorial disease صحيح؟
+
+736
+01:11:54,060 --> 01:11:58,600
+الـ Normal Distribution تعريفه إنه الـ «مين» والـ
+
+737
+01:11:58,600 --> 01:12:02,820
+«مود» والـ «ميديان» «المين» متوسط الحسابي «المود»
+
+738
+01:12:02,820 --> 01:12:08,740
+اللي هو أكتر بقراءة طالعة «الميديان» هو اللي
+
+739
+01:12:08,740 --> 01:12:13,340
+بنرتبهم من الأول لأخر بنحط المنتصف المنصي الـ
+
+740
+01:12:13,340 --> 01:12:18,000
+«ميديان» فدولة كلهم جات بعض فهذا الصحيح الـ «مين»
+
+741
+01:12:18,000 --> 01:12:21,820
+plus minus one standard deviation 67% من
+
+742
+01:12:21,820 --> 01:12:25,930
+الpopulation صحيحاللي تبدو مثلًا كـ Bell-shaped
+
+743
+01:12:25,930 --> 01:12:30,090
+with two tails، صحيح الـmean plus two standard
+
+744
+01:12:30,090 --> 01:12:34,730
+deviations 95% من المجتمع، صحيح الـmany traits and
+
+745
+01:12:34,730 --> 01:12:38,610
+distribution follow
+
+746
+01:12:38,610 --> 01:12:41,550
+this distribution، الـnormal distribution و it's
+
+747
+01:12:41,550 --> 01:12:47,490
+important for research، صحيحة جدًا أقوى familial
+
+748
+01:12:47,490 --> 01:12:52,190
+aggregation، اللي هي الـrisk ratio، اللي هي الرمزة
+
+749
+01:12:52,190 --> 01:12:56,780
+هذهLambda S في هذه الشكلة أيضًا اللي هو الأولى للـ
+
+750
+01:12:56,780 --> 01:13:01,980
+Autism 150 يعني شفت البقية كلهم فيهن بس هي أقوى
+
+751
+01:13:01,980 --> 01:13:06,840
+واحد الدرجات أكبر بكتير يعني
+
+752
+01:13:06,840 --> 01:13:14,960
+الـ Recall مباشر يعني إذا بنلاقي Familial
+
+753
+01:13:14,960 --> 01:13:21,750
+Aggregation of Diseaseبعد مصادر الجنية، أي مصادر
+
+754
+01:13:21,750 --> 01:13:25,950
+قد تشرح الفميلة الـ Aggregation بديوا يكونوا
+
+755
+01:13:25,950 --> 01:13:31,190
+shared environmental exposure يعني والله المرض هذا
+
+756
+01:13:31,190 --> 01:13:36,730
+بيسببوا تسمم بالرصاص مثلا، اللي ما هو إذا طفل
+
+757
+01:13:36,730 --> 01:13:40,870
+اتسمم بالرصاص في هذه العيلة ممكن إخوانه القواكب
+
+758
+01:13:40,870 --> 01:13:44,350
+اللي عايشين عندهم كانوا بتعرضوا لنفس الرصاص لأنهم
+
+759
+01:13:44,350 --> 01:13:48,670
+بيعيشوا بنفس البيئة ف sharedالـ Environmental
+
+760
+01:13:48,670 --> 01:13:52,250
+Exposure هو الـ Other Explanation of the Familial
+
+761
+01:13:52,250 --> 01:13:56,610
+Aggregation of Disease الـ Gene Polymorphism
+
+762
+01:13:56,610 --> 01:14:02,630
+وDevelopmental Of Mutation وSame Family Name يعني
+
+763
+01:14:02,630 --> 01:14:07,490
+كلها مش هي المسببة أو التفسير الآخر للـ Familial
+
+764
+01:14:07,490 --> 01:14:11,010
+Aggregation اللي هي Shared Environmental Exposure
+
+765
+01:14:12,620 --> 01:14:17,600
+السؤال، هذا الأسئلة اللي بعدين هي من المراجع
+
+766
+01:14:17,600 --> 01:14:27,980
+تبعتها فيها يعني قصص أو stories وكذا وبنجيب
+
+767
+01:14:27,980 --> 01:14:34,600
+يعني أظن فيها يعني points مش غلط الواحد يتطلع عليه
+
+768
+01:14:37,480 --> 01:14:44,840
+فيه researcher اللي الواحد بيقراها بده يدرس الـ
+
+769
+01:14:44,840 --> 01:14:53,140
+Fast Ligand Interaction وفي حالة في عائلة بيشوف إن
+
+770
+01:14:53,140 --> 01:14:59,680
+فيها مشكلة فيها أيوة هدين فيه
+
+771
+01:14:59,680 --> 01:15:02,800
+أسئلة كأنه في حد بده
+
+772
+01:15:07,970 --> 01:15:16,090
+الآن الـ… الـ بالنسبة لهذا السؤال فيه بيحكي عن إن
+
+773
+01:15:16,090 --> 01:15:20,010
+الـ Fas-Fas-Ligand interaction مهم عشان الـ
+
+774
+01:15:20,010 --> 01:15:28,070
+control لـ الـ Apoptosis وفي أشياء كتيرة فالـ الآن
+
+775
+01:15:28,070 --> 01:15:34,450
+لقى في هذه الحالة إن الـ Fas-Protein هم كلهم الـ
+
+776
+01:15:34,450 --> 01:15:38,320
+Fas-Fas-Ligand هم عبارة عن self-service proteinفهو
+
+777
+01:15:38,320 --> 01:15:42,960
+بيشرح شو هي وبيحكي معلومات عنها فلاحظ عند العائلة
+
+778
+01:15:42,960 --> 01:15:48,600
+هذه إن الـ Soluble Fas Protein اللي لقاهم Shorter
+
+779
+01:15:48,600 --> 01:15:58,720
+وLacked Transmembrane Domain ماشي؟ لما
+
+780
+01:15:58,720 --> 01:16:03,200
+شاف الـ DNA Analysis of these cells revealed no
+
+781
+01:16:03,200 --> 01:16:10,100
+Fas gene mutationيعني نفس الجين موجود بالثنتين بس
+
+782
+01:16:10,100 --> 01:16:15,260
+الأصل يكون البروتين عبارة عن Trans-Membrane Domain
+
+783
+01:16:15,260 --> 01:16:18,760
+وIntra-Cytoplasmic Membrane والـ Extra-Cytoplasmic
+
+784
+01:16:18,760 --> 01:16:22,480
+يعني Extra-Cytoplasmic والـ Trans-Membrane والـ
+
+785
+01:16:22,480 --> 01:16:27,820
+Intra-Cytoplasmic تاني هيك الأصل فالـ DNA متشابه
+
+786
+01:16:27,820 --> 01:16:32,060
+فالـ explanation
+
+787
+01:16:33,640 --> 01:16:37,040
+اللي هو الـ Alternative Splicing الـ Alternative
+
+788
+01:16:37,040 --> 01:16:43,040
+Splicing اللي هو بيقطع الأشياء الـ Defective
+
+789
+01:16:43,040 --> 01:16:47,320
+polyadenylation و DNA methylation دولة تبعات الـ
+
+790
+01:16:47,320 --> 01:16:52,960
+polygenic أو الـ Epigenetic Control الـ Protein
+
+791
+01:16:52,960 --> 01:16:58,180
+Lubrication والأشياء دي كمال هيتخلط مش هيك من
+
+792
+01:16:58,180 --> 01:17:05,390
+المرجع وإذا كان واحد قارى وعرف يجيبهاأحسن، نعم يا
+
+793
+01:17:05,390 --> 01:17:08,750
+هديل هذا
+
+794
+01:17:08,750 --> 01:17:12,090
+السؤال يعني إحنا لما أنت شرحتينا إياه ماقولتلى ما
+
+795
+01:17:12,090 --> 01:17:14,530
+تركزوش كتير على ال alternatives splicing و الشغلات
+
+796
+01:17:14,530 --> 01:17:17,870
+هذه لإنها مش كتير بتهمك هو صح كلامك إنه السؤال من
+
+797
+01:17:17,870 --> 01:17:23,430
+المرجع بس إن إحنا عندنا الـ أسا اسمع علي، يا هديل،
+
+798
+01:17:23,430 --> 01:17:26,650
+ما بيجيبوني أسألهم اسمع علي يا هديل، غير لما
+
+799
+01:17:26,650 --> 01:17:29,350
+يكونوا إن أنا بدرسها من الكتاب، ماركزتش عليها كتير
+
+800
+01:17:29,350 --> 01:17:37,110
+أفهمي علي، لا لا، افهمي علييعني هي الفكرة الفكرة
+
+801
+01:17:37,110 --> 01:17:42,730
+أنا لازم في الامتحانات أحط بعض الأسئلة الأصعب اللي
+
+802
+01:17:42,730 --> 01:17:49,370
+ما مش كل الناس يجاوبوها ماشي و بعدين يعني أنا ال
+
+803
+01:17:49,370 --> 01:17:54,770
+trick في السؤال هذا النقطة اللي بدي تخبية منه هو
+
+804
+01:17:54,770 --> 01:18:00,190
+بصفلك يعني للأسف السؤال طويل يعني ماشي هو يمكن
+
+805
+01:18:00,190 --> 01:18:04,840
+أصعب من غيرهفالواحد يكون بعض الأسئلة الصعبة مش غلط
+
+806
+01:18:04,840 --> 01:18:14,000
+بالنسبة للأن زي هيك البروتين العادي تفكر لانك يا
+
+807
+01:18:14,000 --> 01:18:19,940
+دكتور بيكون طويل فهمتي؟ والـ DNA يعني هذا البروتين
+
+808
+01:18:19,940 --> 01:18:25,180
+طلق أقصى والـ DNA the same يعني لمّا نقدر نفعث نفس
+
+809
+01:18:25,180 --> 01:18:29,900
+الـ gene تبع الـ DNA على مستوى الـ DNA مالكاش فيه
+
+810
+01:18:29,900 --> 01:18:36,100
+مشكلةففي الحالة هذه المشكلة
+
+811
+01:18:36,100 --> 01:18:39,300
+أو الملاحظة راح تكون إنه في عندي الـAlternative
+
+812
+01:18:39,300 --> 01:18:42,480
+slicing pool most likely يعني by guessing you
+
+813
+01:18:42,480 --> 01:18:49,820
+might have got it أما هو شويه سؤال أصعب و .. أهأنا
+
+814
+01:18:49,820 --> 01:18:52,480
+يا دكتور، لعند إن الـDNA مافيش عليها مشاكل معناها
+
+815
+01:18:52,480 --> 01:18:54,580
+إنه الأشي في الـepigenetics mechanism عشانك أنا
+
+816
+01:18:54,580 --> 01:18:57,760
+يوم حطيتها DNA methylation مادكتش كتير على
+
+817
+01:18:57,760 --> 01:18:59,580
+الـAlternatives of splicing لأن أحنا أصلا مش
+
+818
+01:18:59,580 --> 01:19:00,340
+مابنعرفش على
+
+819
+01:19:00,340 --> 01:19:19,120
+الـ……………………………………………………………………………………………………………………………………………………………………………………
+
+820
+01:19:19,390 --> 01:19:23,490
+ماشي، الـ Epigenetic… «كامل إنهيبش للإنزين ممكن»
+
+821
+01:19:23,490 --> 01:19:28,930
+نعم، لأ لأ، الـ «ممكن تعمل إنهيبش للبروتين» يعني
+
+822
+01:19:28,930 --> 01:19:33,750
+أيه؟ «ممكن تعمل أيه، دكتور؟» الـ Epigenetic
+
+823
+01:19:33,750 --> 01:19:40,570
+Control هو بيقرر هل البروتين هذا هيطلع ولا لأ بس
+
+824
+01:19:40,570 --> 01:19:44,750
+ما بيغير بالبروتين يعني هي بيغير كمية اللي طلع منه
+
+825
+01:19:44,750 --> 01:19:49,200
+بس ما بيغير في شكل البروتين نفسهفالقصص اللي
+
+826
+01:19:49,200 --> 01:19:53,980
+بيحكيلك إياها في الـ Fast Protein اللي طلعت هنا هي
+
+827
+01:19:53,980 --> 01:19:58,220
+على مسكواة إحنا حكينا اللي بدل واحد يتذكر إنه أول
+
+828
+01:19:58,220 --> 01:20:02,400
+شيء الـ DNA بيصير له Messenger RNA أو للـ RNA الـ
+
+829
+01:20:02,400 --> 01:20:06,820
+Primary وفيه Introns و Extrons وبيصير قطة أو لسق
+
+830
+01:20:06,820 --> 01:20:09,440
+وبالذات لما نقوله Trans-Membrane وIntra
+
+831
+01:20:09,440 --> 01:20:13,180
+-Cytoplasmic Domain هذه بالـ Alternative Splicing
+
+832
+01:20:13,810 --> 01:20:18,510
+يعني حتى أنا بالنسبة لموضوع زي الـSecreted وCell
+
+833
+01:20:18,510 --> 01:20:23,850
+Surface Form of Immunoglobulins بالمنعها، أمر على
+
+834
+01:20:23,850 --> 01:20:27,310
+مستوى الـRNA بالـAlternative Splicing، يعني مافيه
+
+835
+01:20:27,310 --> 01:20:30,590
+إشي بالمرحلة دي، على كل ما –يعني يا دكتور، حكيت
+
+836
+01:20:30,590 --> 01:20:34,690
+نفسي أول ما جيبت نفسي ريتها وانت بتشرحها –إيش هو؟
+
+837
+01:20:34,690 --> 01:20:39,510
+أسا ماجيبتهاش وماجيبتها الله يرضى عليكي، أنت أسا
+
+838
+01:20:39,510 --> 01:20:43,230
+المهم جيبيها ولمّا تيجي تدرس الـUSMLE، جيبيها صح
+
+839
+01:20:43,550 --> 01:20:49,610
+فبنجيلك زي هيك إنه فيه مشكلة إنه أكتر من Form اللي
+
+840
+01:20:49,610 --> 01:20:53,430
+صارت يعني أو اللي هي راح نجي بعدين أنا لأن ما كنت
+
+841
+01:20:53,430 --> 01:20:59,490
+شرحتها سبب ثاني إذا بيحكوا عنه اللي هو الـ Stop
+
+842
+01:20:59,490 --> 01:21:04,430
+Codon يعني سبب ثاني يعني بدل ما هي البروتين طويل
+
+843
+01:21:04,430 --> 01:21:08,650
+كتير وفيه أكتر من قطعة إذا فيه Stop Codon ممكن
+
+844
+01:21:08,650 --> 01:21:12,070
+يكون تفسير آخر يعني لو حطوا Stop Codon يمكن أنت
+
+845
+01:21:12,070 --> 01:21:19,590
+كنت راح أقبلهعلى كل المعرفة هديل إذا ما عليك ترجع
+
+846
+01:21:19,590 --> 01:21:22,950
+إلى المرجع اللي أخدت السؤال منه هيحطته فيه موجود
+
+847
+01:21:22,950 --> 01:21:27,410
+مفروض عندكم وإقرأ ال explanation ليش باقية الأشياء
+
+848
+01:21:27,410 --> 01:21:32,490
+مابتدفعش فاهمي عليك؟ قرأته قرأته والله قرأته بس
+
+849
+01:21:32,490 --> 01:21:35,190
+إنه أنا قصدي إنه هذا يعني هذا إشي إحنا ماأخدنهش
+
+850
+01:21:35,190 --> 01:21:37,990
+يعني ماكنش في نطاق درستنا لما درستنا للامتحان فإنه
+
+851
+01:21:37,990 --> 01:21:42,260
+يعني يعني السؤال يعني المفروض إن مثلالأ لما .. لأ
+
+852
+01:21:42,260 --> 01:21:47,680
+لأ لأ لأ لأ اسمع عليك اسمع عليك لأ لأ لأ ما شو أحط
+
+853
+01:21:47,680 --> 01:21:53,200
+شو ما أحط أنا كل ما تطلعوا أحسن اسمع عليك كل ما
+
+854
+01:21:53,200 --> 01:21:59,860
+تطلعوا أحسن تكونوا أحسن ماشي و أنا بظن يعني أنا
+
+855
+01:21:59,860 --> 01:22:03,400
+اللي عجبني على الأقل حتى بالإجابة الأولى كنت راحلة
+
+856
+01:22:03,400 --> 01:22:07,000
+لما أقرأ الإجابات و أقرأ السؤالالفرق في إنه
+
+857
+01:22:07,000 --> 01:22:11,660
+الاختلاف الـ methylation مش راح يوقف الـ البروتين
+
+858
+01:22:11,660 --> 01:22:16,200
+ولا الـ polyadenylation ولا الـ RNA يعني ممكن
+
+859
+01:22:16,200 --> 01:22:19,900
+الشغل على الـ messenger RNA كنت راح أشوف فيه لو
+
+860
+01:22:19,900 --> 01:22:22,960
+ماكنتش عارف أنها أيه يعني بس قريت الـ stem اللي
+
+861
+01:22:22,960 --> 01:22:28,820
+فوق على كل حال يعني السؤال يمكن خلافك على إنه هل
+
+862
+01:22:28,820 --> 01:22:35,490
+هذا مناسب نجيبه ولا مانجيبوشبقول ممكن أنه أنا جيت
+
+863
+01:22:35,490 --> 01:22:39,870
+إشي من المرجع ممكن أنتم طلعتوا عليها وما طلعتوش
+
+864
+01:22:39,870 --> 01:22:44,070
+عليها وما .. ما بتلزموني أنه لازم تجيب سؤال اللي
+
+865
+01:22:44,070 --> 01:22:47,950
+أنا كنت شرحته ولا ما شرحته إذا عايشي في المرجع،
+
+866
+01:22:47,950 --> 01:22:51,830
+إذا عايشي في المرجع أو في اللي .. اللي أنا شرحته
+
+867
+01:22:51,830 --> 01:22:56,610
+بالكلام فهو كلام مقبول، على كل درجة ما هو يا
+
+868
+01:22:56,610 --> 01:23:00,010
+دكتور، بس إحنا مارجعنا الكتاب، مارجعنا كل كتاب
+
+869
+01:23:00,010 --> 01:23:03,240
+كتاببس احنا مارجعنا الكتاب و كلامك في المادة، صح
+
+870
+01:23:03,240 --> 01:23:08,140
+ولا لأ؟ هذا كان كلام صحيح، بس اسمع عليه، اسمع
+
+871
+01:23:08,140 --> 01:23:13,360
+عليه، الأشياء، الأشياء اللي فيها MCQ زي هيك سهلة
+
+872
+01:23:13,780 --> 01:23:18,820
+أنا إن شاء الله لما نخلص ال .. أنا جد مادخلتش
+
+873
+01:23:18,820 --> 01:23:22,200
+المراجع التاني سبعة ال «unsecured» أنا ماكن قصدي
+
+874
+01:23:22,200 --> 01:23:25,680
+بس هذا الكتاب اللي أنتم بدكم ترجعوا إليه شاهد
+
+875
+01:23:25,680 --> 01:23:29,040
+عليه؟ و من دكتور أحمد تفاهمي هو دكتور كتاب
+
+876
+01:23:29,040 --> 01:23:31,880
+«تومسون» يعني كتاب «تومسون» كتير كتير كبير و كتير
+
+877
+01:23:31,880 --> 01:23:33,400
+متعين في الدراسة دكتور حديث، دكتور حديث، دكتور
+
+878
+01:23:33,400 --> 01:23:34,340
+حديث، دكتور حديث، دكتور حديث، دكتور حديث، دكتور
+
+879
+01:23:34,340 --> 01:23:38,680
+حديث، دكتور حديث، دكتور حديث، دكتور حديث، دكتور
+
+880
+01:23:38,680 --> 01:23:46,010
+حديث، دكتور حديفيه بروتين أكتر من segment واتوقف
+
+881
+01:23:46,010 --> 01:23:51,490
+عند segment معينة المشكلة هي ممكن في stop codon
+
+882
+01:23:51,490 --> 01:23:56,830
+بالأخير يعطيني shorter messenger RNA أو
+
+883
+01:23:56,830 --> 01:24:02,550
+بالـAlternative splicing، ماجبش شي على تكون هيك
+
+884
+01:24:02,550 --> 01:24:07,390
+أنا الساعة عشر عندى محاضرة تانية وعندى شغل تانيأه
+
+885
+01:24:07,390 --> 01:24:12,350
+لك الله يا دكتور، اللي إحنا يعني بدناش نجف على
+
+886
+01:24:12,350 --> 01:24:18,230
+يعني نقطة معينة مثلا، الدكتور لما حكى السؤال بحد
+
+887
+01:24:18,230 --> 01:24:21,210
+ذاته، بيتكلم مش عن انفاص بروتين ولا بيتكلم على
+
+888
+01:24:21,210 --> 01:24:26,390
+القضايا هذه، بيتكلم عن صناعة البروتينأعتقد النقطة
+
+889
+01:24:26,390 --> 01:24:30,070
+دي اتحدث عنها الدكتور و ربما ذكرها كتاب «تومسون»
+
+890
+01:24:30,070 --> 01:24:33,830
+فالفكرة أنه حتى الامتحان نفسه احنا بنتعلم كمان منه
+
+891
+01:24:33,830 --> 01:24:37,250
+و الأسئلة اللي تيجي في الامتحان احنا بناخد منها
+
+892
+01:24:37,250 --> 01:24:41,350
+معلومات فمش هنجف عند كل سؤال نقول هذا لأجان و هذا
+
+893
+01:24:41,350 --> 01:24:45,430
+مجاناش، مظبوط إزايك و يعني المادة بتمشيش صحيح
+
+894
+01:24:45,430 --> 01:24:50,190
+خليني بالمية الكلام اللي قصديها، الآن الأسئلة
+
+895
+01:24:50,190 --> 01:24:55,420
+الباقية كلها من مراجع من براالآن healthy couple
+
+896
+01:24:55,420 --> 01:25:06,440
+وعندهم autosomal recessive disease ماشي وأجت ال ال
+
+897
+01:25:06,440 --> 01:25:10,180
+next child what is the probability to be affected
+
+898
+01:25:10,180 --> 01:25:18,120
+الربع ماشي standard لأنههم من متقاربين احتمال مش
+
+899
+01:25:18,120 --> 01:25:21,600
+Consanguinity بس أثنانهم من Eastern Europe في
+
+900
+01:25:21,600 --> 01:25:27,780
+أمريكا وFirst Diseased Child في الغالب بمعنهم Too
+
+901
+01:25:27,780 --> 01:25:33,340
+Healthy معناتها هدولة Ethosomal Recessive وبالتالي
+
+902
+01:25:33,340 --> 01:25:41,620
+كل Birth الاحتمالية ربع السؤال اللي بعده فيه إشي
+
+903
+01:25:41,620 --> 01:25:47,190
+يعني الاللي هو بيسموه Transcription Regulators
+
+904
+01:25:47,190 --> 01:25:53,730
+برضه هذا يعني إنكن أنا ما عرضتوش كتير بس شفت إنه
+
+905
+01:25:53,730 --> 01:25:58,970
+مهم من ناحية الـ يعني اقرأوا المرجعين هدولة يعني
+
+906
+01:25:58,970 --> 01:26:06,570
+على قل يعني بتكون فيها Points اللي هو
+
+907
+01:26:06,570 --> 01:26:12,260
+Transcription RegulatorsH1 هستون برضه ما شرحتهاش
+
+908
+01:26:12,260 --> 01:26:19,440
+أبداً بس برضه يعني ترتيبها والـ يعني بداية الـ
+
+909
+01:26:19,440 --> 01:26:29,640
+guessing شكل شو اسمه مفيد 26 year old woman فيه
+
+910
+01:26:29,640 --> 01:26:37,330
+الآن high autosomal resistance storyالـ story مش
+
+911
+01:26:37,330 --> 01:26:41,770
+مهمة، يعني بالأخير واحد ياخد الفكرة إذا أتزامل،
+
+912
+01:26:41,770 --> 01:26:47,070
+what is the probability that the unborn child will
+
+913
+01:26:47,070 --> 01:26:51,610
+inherit one or more؟ يعني هل هو heterozygous or
+
+914
+01:26:51,610 --> 01:26:55,310
+homozygous for the disease؟ راح يكون بما أن ال
+
+915
+01:26:55,310 --> 01:26:58,810
+disease موجود في العائلة وال two parents are
+
+916
+01:26:58,810 --> 01:27:03,510
+carriers فboth are obligate heterozygous، لازم
+
+917
+01:27:03,510 --> 01:27:10,370
+يكونوا heterozygousفبكون 75% المثال اللي حاطينه
+
+918
+01:27:10,370 --> 01:27:17,590
+هنا 47 الـ pedigree لـ X-linked recesses ولد أو
+
+919
+01:27:17,590 --> 01:27:23,750
+شاب أو حدا وخاله مصابين فالواحد وخاله لما بتشوفهم
+
+920
+01:27:23,750 --> 01:27:31,290
+هدولة X-linked recesses الـ high female جاي بـ two
+
+921
+01:27:31,290 --> 01:27:35,900
+down syndromeفهي مش Non-disjunction عمرها 26 سنة
+
+922
+01:27:35,900 --> 01:27:42,220
+يعني صغير بالعمر فمش Non-disjunction فالسبب إذا
+
+923
+01:27:42,220 --> 01:27:46,160
+بتصير هذه اللي هي Reciprocal Translocation مع
+
+924
+01:27:46,160 --> 01:27:51,660
+Chromosome 21 عادة بركب على Chromosome 14 فهي
+
+925
+01:27:51,660 --> 01:27:57,260
+عندها بتعطي أولادها Two copies of Chromosome 22
+
+926
+01:27:57,260 --> 01:28:02,690
+و21يعني والأب بيعطي one copy فبصير down syndrome
+
+927
+01:28:02,690 --> 01:28:10,150
+هاي زيادة a man with hemophilia A له X-linked
+
+928
+01:28:10,150 --> 01:28:16,950
+recessive والذوج واحدة heterozygous
+
+929
+01:28:16,950 --> 01:28:23,690
+career ف what proportion فالزلمة ال X تبعه مصاب
+
+930
+01:28:23,690 --> 01:28:28,650
+وال Y طبيعي أو ال Y مالوش دخلزوج واحدة عندها طبيعي
+
+931
+01:28:28,650 --> 01:28:35,850
+ومصاب فالابنات تبعتهم اللي
+
+932
+01:28:35,850 --> 01:28:41,930
+بيكون فيه نسبة خمسين بالمية بيكونوا مصابين وخمسين
+
+933
+01:28:41,930 --> 01:28:46,810
+بالمية بيكونوا Carriers لازم يكون هيك الـ Marfan
+
+934
+01:28:46,810 --> 01:28:54,400
+Syndrome اللي هي Autosomal Dominant وصار عندهابينت
+
+935
+01:28:54,400 --> 01:28:58,340
+في عائلة ودورت في كل العائلة ما في حد عنده مثل هذا
+
+936
+01:28:58,340 --> 01:29:03,800
+الشيء فهذه البنت أخدتها من الـ New Mutation صارت
+
+937
+01:29:03,800 --> 01:29:12,020
+في أحد أبويها اللي هي الـ D وخمسين اللي هو اسمه
+
+938
+01:29:12,020 --> 01:29:16,340
+Miss Sense Mutation اللي بعطيني هذا الشيء أنا مضطر
+
+939
+01:29:16,340 --> 01:29:22,670
+عندي تدريس ثاني إذا في أسئلة على الـ Geneticsهذه
+
+940
+01:29:22,670 --> 01:29:26,850
+كلها من المرجع تطلعوا عليه وإن شاء الله المرات
+
+941
+01:29:26,850 --> 01:29:31,110
+الجاية برضه راح ناخد محاضرات تبقى نسوي revision من
+
+942
+01:29:31,110 --> 01:29:35,550
+خلال أسئلة وده في عندكم أسئلة عامة ماشي دكتور أحمد
+
+943
+01:29:35,550 --> 01:29:40,170
+أنا مضطر أطلع الآن عشانك يا دكتور مشكور جدا على
+
+944
+01:29:40,170 --> 01:29:44,530
+يعني وقتك اللي … لا هذا واجب مافي مشكلة إن شاء
+
+945
+01:29:44,530 --> 01:29:49,120
+الله نكون بنفيد والـWhatsApp groupالـ WhatsApp
+
+946
+01:29:49,120 --> 01:29:54,120
+Group إذا حد بخطللي سؤال عليه يعني أخوة وأخوات
+
+947
+01:29:54,120 --> 01:30:02,320
+زملاء كتير بودولي على الخاص إلي لوحدي فيعني ما في
+
+948
+01:30:02,320 --> 01:30:08,660
+مشكلة دايماً بطلب إنه ابعته على التبعين الكل وأنا
+
+949
+01:30:08,660 --> 01:30:15,040
+يعني على طول إذا بشوف أي سؤال برد عليه وخلّينا نرد
+
+950
+01:30:15,040 --> 01:30:20,370
+من خلال الـ Groupويخلّيها الواحد على الأسئلة أما
+
+951
+01:30:20,370 --> 01:30:26,570
+ان داخل مش داخل شرحته وما شرحتوش هذا بنفع هذا
+
+952
+01:30:26,570 --> 01:30:32,010
+بنفعش ما ندخلش في هذا السهل يعني واجبي وزي ما
+
+953
+01:30:32,010 --> 01:30:35,430
+اتفضل الدكتور أحمد أنه من خلال الانتحار الواحد
+
+954
+01:30:35,430 --> 01:30:39,910
+كمان بتعلم يعني أنا مابتذكرشالأسئلة اللي جوابتها
+
+955
+01:30:39,910 --> 01:30:43,950
+صح في المواد بس اللي عارق في مخي أكتر من اليوم مرة
+
+956
+01:30:43,950 --> 01:30:48,610
+الأشياء اللي جوابتها غلط وعارفت ليش جوابتها غلط
+
+957
+01:30:48,610 --> 01:30:53,510
+خلوا أحد جزء من الدراسة نشوف المراجع أنا المراجع
+
+958
+01:30:53,510 --> 01:30:57,630
+اللي فيها أسئلة ماقدتش أبدأ فيها من ناحية إنه
+
+959
+01:30:57,630 --> 01:31:02,770
+خلّينا ناخد شوية يعني خميرة من المعلومات العلمية
+
+960
+01:31:02,770 --> 01:31:08,880
+وأخيرًا يعني تفاصيل الأمراض، هاي إن شاء اللهعندكم
+
+961
+01:31:08,880 --> 01:31:13,980
+طريق طويل تاخدوها بعدين يالله يعطيكم العافية يعطيك
+
+962
+01:31:13,980 --> 01:31:17,820
+ألف عافية دكتور الله يحييكم نشوفكم يوم الأربعة ان
+
+963
+01:31:17,820 --> 01:31:22,920
+شاء الله رب العالمين يعطيكم العافية دكاترة نشوفكم
+
+964
+01:31:22,920 --> 01:31:23,600
+ان شاء الله يوم الأولى
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/A4ftaxBd5gA_raw.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/A4ftaxBd5gA_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..f59f1251722ebe7adadd1d56e13342af43745763
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/A4ftaxBd5gA_raw.srt
@@ -0,0 +1,3856 @@
+1
+00:00:00,000 --> 00:00:05,100
+فصول أو هن أربعة يعني في فصلين قريبات من بعض
+
+2
+00:00:05,100 --> 00:00:12,600
+وإقصار فممكن ناخدهم في فصل وفي فصل عن الـ ethical
+
+3
+00:00:12,600 --> 00:00:17,960
+considerations الجوانب الأخلاقي ممتاز يعني كويس أن
+
+4
+00:00:17,960 --> 00:00:24,380
+الواحد يتناوله في هذا الجانب فقداش بقينا للمساق؟
+
+5
+00:00:24,380 --> 00:00:31,760
+هو احنا تقريبا حاليا في الأسبوع أعتقدتاسع يعني
+
+6
+00:00:31,760 --> 00:00:36,060
+يتبقى حوالي أربع أسابيع يعني على .. على يعني أقصى
+
+7
+00:00:36,060 --> 00:00:40,020
+تقضية أربع أسابيع أو يعني إشي زييك يعني أنا كل
+
+8
+00:00:40,020 --> 00:00:43,900
+أسبوع بكون محاضرتين يعني إذا قولنا ست .. ست يعني
+
+9
+00:00:43,900 --> 00:00:47,940
+بالمتوسط ست محاضرات أو خمسة يعني انا .. انا حابب
+
+10
+00:00:47,940 --> 00:00:51,720
+الصراحة أحداشر اه انا في شباب بيقولوا احنا الأسبوع
+
+11
+00:00:51,720 --> 00:00:57,120
+أحداشر خلاص تمامتقريبًا، يعني تقريبًا زي ما قلت ست
+
+12
+00:00:57,120 --> 00:01:00,420
+محاضرات تقريبًا بالمعدل هات ست محاضرات إن شاء الله
+
+13
+00:01:00,420 --> 00:01:08,420
+أنا حابب أني … to overview كبلان والـ … والـ USMLE
+
+14
+00:01:08,420 --> 00:01:12,920
+والـ Medical Genetics الـ References الثانية الـ
+
+15
+00:01:12,920 --> 00:01:18,260
+Summaries والهذه الأشياء يعني أنا بالأول ماحبتش
+
+16
+00:01:18,260 --> 00:01:26,090
+أنينستخدمهم باعتبار أنه فيهم يعني شرح كويس
+
+17
+00:01:26,090 --> 00:01:31,050
+للمفاهيم عبارة عن أسئلة يعني بدك تكون انت مر عليك
+
+18
+00:01:31,050 --> 00:01:37,990
+المفاهيم وهذه بتكون تذكير فيها يعني فإن شاء الله
+
+19
+00:01:37,990 --> 00:01:44,870
+احنا اليوم راح نراجع الأسئلة ويعني
+
+20
+00:01:44,870 --> 00:01:51,890
+حابب ده فيهأنا بشكل عام الأسئلة
+
+21
+00:01:51,890 --> 00:01:57,210
+يعني كانت في كثير منها سهلة يعني في كثير منها
+
+22
+00:01:57,210 --> 00:02:02,990
+difficult index كان مرتفع تقريباً الكل أو نسبة
+
+23
+00:02:02,990 --> 00:02:11,020
+عالية80، 90، 70% جابوها وفي سؤالين، ثلاثة بس اللي
+
+24
+00:02:11,020 --> 00:02:18,380
+فيهم مشاكل كان يعني واحد بس اللي تحت الـ 20% جاوبه
+
+25
+00:02:18,380 --> 00:02:28,020
+صح فممكن احنا نراجع الأسئلة ويعني حابب إنه الـ
+
+26
+00:02:29,230 --> 00:02:34,630
+الطلاب هم اللي جابوا أو على أقل إذا حد عنده أي
+
+27
+00:02:34,630 --> 00:02:38,590
+استفسار في بعضهم بدوا يودوا أسئلة كيف هيك و ليش
+
+28
+00:02:38,590 --> 00:02:45,290
+هيك و كده أحنا ما بديش أقول تغيير بقدر ما أنه
+
+29
+00:02:45,290 --> 00:02:52,590
+اتفقنا مع دارة الكلية أنه مراجع زي الـ USMLE يعني
+
+30
+00:02:52,590 --> 00:02:59,640
+هي تقريبًا كل اللي أنا شرحتهفيها، بس في جوانب يعني
+
+31
+00:02:59,640 --> 00:03:05,620
+على قل «so far» بالنسبة للامتحان الأول فيه نقطتين
+
+32
+00:03:05,620 --> 00:03:10,180
+يعني هيك ببالي أنه نعيد شرحهم بطريقة أو يعني نركز
+
+33
+00:03:10,180 --> 00:03:16,160
+عليهم لأن الواحد لازم يكون منتبه عليهم فالآن
+
+34
+00:03:16,160 --> 00:03:23,940
+يعني بطلب من الشباب الدكاترة والدكتورات أنهيعني
+
+35
+00:03:23,940 --> 00:03:28,720
+بالذات كمان الـ MCQs كأسئلة يعني احنا الغالبية
+
+36
+00:03:28,720 --> 00:03:35,200
+العظمة من الطب والعلم والمبادئ أخدناها يعني تقريبا
+
+37
+00:03:35,200 --> 00:03:41,080
+المفروض الواحد عنده حصيلة جيدة بيظل أنه بده يأخذ
+
+38
+00:03:41,080 --> 00:03:46,780
+حصيلة أخرى من الحالات السريرية ويعني يفكر في
+
+39
+00:03:46,780 --> 00:03:52,120
+الموضوع من خلال الأمراض يعني هيك القصد، فماشي
+
+40
+00:03:52,120 --> 00:03:58,710
+الحالفي أسئلة؟ إن شاء الله يعني أنا يعني في إمكاني
+
+41
+00:03:58,710 --> 00:04:03,770
+أي حد بيقدر يعمل unmute للـ للحساب تبعه ويتكلم مع
+
+42
+00:04:03,770 --> 00:04:09,450
+الدكتور بشكل عام مباشر مافي مشكلة مافي مشكلة هبدأ
+
+43
+00:04:09,450 --> 00:04:19,390
+وسوي share screen عشان بالنسبة لتشوف الأسئلة و
+
+44
+00:04:23,540 --> 00:04:31,460
+انتبهت دكتور أحمد أني أنا هتعطيك واحد وخمسين سؤال
+
+45
+00:04:31,460 --> 00:04:36,360
+مش خمسين، في سؤال كان مشبوك اتنين ببعض، في مرات
+
+46
+00:04:36,360 --> 00:04:45,820
+واحد يعني مهما يبدو الجهد بيظل يعني بيظل في بعض
+
+47
+00:04:45,820 --> 00:04:51,040
+المرات هيك بنتبهش في أشياء و بيحاول أنه يعني
+
+48
+00:04:51,040 --> 00:04:56,130
+يعملها مظبوططيب، لعنة خير، لعنة خير المشكلة
+
+49
+00:04:56,130 --> 00:05:00,850
+الثانية بالنسبة
+
+50
+00:05:00,850 --> 00:05:08,450
+للـ الـ الـ file تبع الـ Excel تبع التقييم الأسئلة
+
+51
+00:05:08,450 --> 00:05:13,390
+عابه أو مشكلته مش بنفس الترتيب اللي أنا أعطيتكميه
+
+52
+00:05:13,390 --> 00:05:21,230
+يعني مرات بكون يعني أنا ماعرفش السؤال الصعب ولا
+
+53
+00:05:21,230 --> 00:05:31,080
+السهلالمهم طيب إحنا المحاضرة اليوم قصيرة إن شاء
+
+54
+00:05:31,080 --> 00:05:39,020
+الله وإذا حد عنده أسئلة هاي موجودة عندكم اللي
+
+55
+00:05:39,020 --> 00:05:47,400
+بتفرج أنا عليه، ماشي؟ الآن النقطة الأولى All are
+
+56
+00:05:47,400 --> 00:05:51,200
+true about the origin of genetics understanding by
+
+57
+00:05:51,200 --> 00:05:52,100
+Mendel except
+
+58
+00:05:54,950 --> 00:06:01,310
+طبعًا يعني دائمًا من الأشياء المفهومة أنه هو اشتغل
+
+59
+00:06:01,310 --> 00:06:05,470
+على الـ Bees ولمّا
+
+60
+00:06:05,470 --> 00:06:11,510
+اشتغل أعلن التجارب تبعته ونشرها بس ما حدا قبلها،
+
+61
+00:06:11,510 --> 00:06:15,690
+ما حدا طلّى عليها يمكن تلاتين سنة بعدين كانوا
+
+62
+00:06:15,690 --> 00:06:20,710
+اكتشفوا وكان هو أول إنسان بتكلم عن صفات سائدة
+
+63
+00:06:20,710 --> 00:06:26,330
+ومتنحيةوكدا، هو درس تمان خواص في الـ… في
+
+64
+00:06:26,330 --> 00:06:33,050
+الـBasella الطول قصيرة ولا طويلة، اللون الجعلقة
+
+65
+00:06:33,050 --> 00:06:37,570
+ولا smooth تاكه، يعني الـSurface تبع حتة
+
+66
+00:06:37,570 --> 00:06:44,630
+الـBasella الـ… الوردة تبعتها طرفية من فوق، يعني
+
+67
+00:06:44,630 --> 00:06:50,150
+بنهاية النبات من فوق ولا بتجند، يعني تمان خواص
+
+68
+00:06:50,700 --> 00:06:59,000
+والحفظ يعني نصيبه كان الملاحظة تبعته إنه بالنسبة
+
+69
+00:06:59,000 --> 00:07:02,860
+له كل الـ traits دولة كانوا على different
+
+70
+00:07:02,860 --> 00:07:09,520
+chromosomes فهذه الصدفة تبعته يعني تظبطت معاه إنه
+
+71
+00:07:09,520 --> 00:07:14,050
+كان عنده segregation of character يعنيإنه ما كان
+
+72
+00:07:14,050 --> 00:07:21,750
+فيه يعني إرتباط بين أي صفتين كان يدرسهم أحيانًا
+
+73
+00:07:21,750 --> 00:07:25,370
+إذا الـ «تو جين» كانت مع نفسها كروموزوم ومرتبطة
+
+74
+00:07:25,370 --> 00:07:32,790
+«تو» كانت مرتبطة مع بعض ويكون فيه اختلاف عن النسب
+
+75
+00:07:32,790 --> 00:07:38,530
+والأشياء اللي جابها فهذه السؤال الأول، فيه أسئلة؟
+
+76
+00:07:39,350 --> 00:07:44,090
+إذا حد عنده أي سؤال يعني أنا بشرح شوه فكرة السؤال
+
+77
+00:07:44,090 --> 00:07:49,950
+الأهمشي إن واحد ياخد الفكرة بغض النظر يعني بدي
+
+78
+00:07:49,950 --> 00:07:55,630
+أتعود على الـArticulation يعني طريقة كتابة السؤال
+
+79
+00:07:55,630 --> 00:08:02,050
+لكل واحد إيه طريقة يعني كأستاذ أو حتى في الـUSMLE
+
+80
+00:08:02,050 --> 00:08:06,600
+يعني من هيك الأشياء اللي لازم تنتبه إلهابالنسبة
+
+81
+00:08:06,600 --> 00:08:10,640
+للـ USMLE مرات بيحطوا أسئلة عشان يقيموا الأسئلة
+
+82
+00:08:10,640 --> 00:08:14,500
+يعني بيكونوا هم مش عارفين لسه هل هذا السؤال واضح،
+
+83
+00:08:14,500 --> 00:08:21,060
+مش واضح، في مرات الإشكالية بتكون إنه الصياغة فيها،
+
+84
+00:08:21,060 --> 00:08:26,580
+يعني أنا بالنسبة لفي سؤال عن، راح نيجي بعدين
+
+85
+00:08:26,580 --> 00:08:30,380
+بتفجيكم إياه الإختلف عن المرة الأولى اللي عملتموها
+
+86
+00:08:30,380 --> 00:08:35,080
+الفاصلة، القامةبجرد إن حطيتها ولا ما حطيتها عشان
+
+87
+00:08:35,080 --> 00:08:41,540
+أفرقت شويه أو أوضحت أكتر السؤال
+
+88
+00:08:41,540 --> 00:08:48,300
+الثاني All are true statements الـGene's
+
+89
+00:08:48,300 --> 00:08:51,760
+definition هو segments of the DNA that get
+
+90
+00:08:51,760 --> 00:08:55,940
+transcribed to RNA and proteins الـGenome هو
+
+91
+00:08:55,940 --> 00:09:00,990
+الـAll genes of a cell أو living organismالـ Human
+
+92
+00:09:00,990 --> 00:09:04,590
+Genome Project قعد حوالي عشر سنين خلصته قريبًا
+
+93
+00:09:04,590 --> 00:09:10,750
+بالـ 2003 أول Whole Genome كان Drosophila اللي هو
+
+94
+00:09:10,750 --> 00:09:16,190
+دبابة الفاكهة دبابة الفاكهة فيها أربع كروموزومات
+
+95
+00:09:16,190 --> 00:09:20,410
+فاعتبروا إنها راح تكون أصغر واحدة وتكون سهلة تنعمل
+
+96
+00:09:20,410 --> 00:09:26,720
+فلما عملوا Sequence كان دا الـDrosophilaالآن
+
+97
+00:09:26,720 --> 00:09:31,220
+الإمكانية عمل الـ Whole-Genome Sequencing وكده
+
+98
+00:09:31,220 --> 00:09:38,100
+بتكون لأن الـ Machinery والتكنولوجيا يعني الآن
+
+99
+00:09:38,100 --> 00:09:45,900
+ملايين المرات الـ… الـMachines تريد الـSequence
+
+100
+00:09:45,900 --> 00:09:50,840
+DNA are much faster، much stronger أحسن من تبعات
+
+101
+00:09:50,840 --> 00:09:59,570
+زمان، كانت أبطأوأقل كفاءة، ماشي، هي أسئلة، فالهنا
+
+102
+00:09:59,570 --> 00:10:03,770
+الـ third genome was for Drosophila، هاي الخطأ
+
+103
+00:10:03,770 --> 00:10:08,730
+السؤال
+
+104
+00:10:08,730 --> 00:10:14,590
+التالت، all are areas used for genetics and
+
+105
+00:10:14,590 --> 00:10:18,590
+genomics؟ الـ cancer، ال forensic medicine، الطب
+
+106
+00:10:18,590 --> 00:10:22,360
+الشرعي؟Disease management and pathogenesis، الـ
+
+107
+00:10:22,360 --> 00:10:26,420
+Transplantation كلهم بدهم الـ Genetics وGenomics
+
+108
+00:10:26,420 --> 00:10:32,040
+الـ Political Science وما له دخل مع أنه يعني مش
+
+109
+00:10:32,040 --> 00:10:38,060
+كتير غلط إنه حتى بالنسبة للسياسة
+
+110
+00:10:38,060 --> 00:10:41,420
+الجينات
+
+111
+00:10:41,420 --> 00:10:46,850
+أحيانًا تدخل في الـيعني في العلوم السياسية،
+
+112
+00:10:46,850 --> 00:10:52,650
+التفريق العنصري يعني
+
+113
+00:10:52,650 --> 00:10:57,530
+فيه مرات أشياء، أفكار يعني القومية العربية مثلا
+
+114
+00:10:57,530 --> 00:11:02,050
+يمكن تعتمد على جينات معينة وكذا القوميات وكذا،
+
+115
+00:11:02,050 --> 00:11:12,670
+يعني السؤال الرابع الـDNA usually is loose the DNA
+
+116
+00:11:12,670 --> 00:11:17,720
+becomes condensedوDensely compacted يعني في أكتر
+
+117
+00:11:17,720 --> 00:11:25,200
+شيء بيسميه كروموزوم It's not a DNA probe
+
+118
+00:11:25,200 --> 00:11:30,980
+الكروماتين هو segment من الكروموزوم بيكون موجود في
+
+119
+00:11:30,980 --> 00:11:37,620
+حالة ما لم يتم استخدامه اللايسوزوم لأ هو vacuole
+
+120
+00:11:37,620 --> 00:11:43,720
+أو organelle in the cell اللايسوزوموالـ
+
+121
+00:11:43,720 --> 00:11:49,340
+Environmental factors ما لهم بحاجة آه يا محمود إذا
+
+122
+00:11:49,340 --> 00:11:52,600
+في سؤال؟
+
+123
+00:11:52,600 --> 00:11:56,900
+في حد رفع إيده؟
+
+124
+00:11:56,900 --> 00:12:08,360
+تقريباً لأ طيب، ليش هيكي هذا؟ بس ثواني، خليني
+
+125
+00:12:13,390 --> 00:12:21,210
+مرة تانية حاول
+
+126
+00:12:21,210 --> 00:12:33,050
+أنزل تحت طيب لما
+
+127
+00:12:33,050 --> 00:12:37,850
+نكون، احنا يعني لازم نفكر بالنسبة للـGenetic
+
+128
+00:12:37,850 --> 00:12:42,750
+Diseases into three types، main typesفي الـ
+
+129
+00:12:42,750 --> 00:12:48,530
+Mendelian هو اللي هو بيكون single gene disease due
+
+130
+00:12:48,530 --> 00:12:56,870
+to single gene الـ other type بيكون many يعني
+
+131
+00:12:56,870 --> 00:13:01,410
+whole segment of either the whole chromosome أو
+
+132
+00:13:01,410 --> 00:13:04,630
+segment of ال chromosome بنسميه chromosomal
+
+133
+00:13:04,630 --> 00:13:09,450
+diseaseماشي، Multiple genes مع بعض ويكون ده هو
+
+134
+00:13:09,450 --> 00:13:13,070
+الـChromosome يعني زي الـDown Syndrome، Turner,
+
+135
+00:13:13,490 --> 00:13:17,470
+Klinefelter أشياء زي هيك، بدنا نسميها Chromosomes
+
+136
+00:13:17,470 --> 00:13:27,330
+البقية Epigenetic وPolygenic دولة عبارة عن اللي هو
+
+137
+00:13:27,330 --> 00:13:31,070
+إحنا بنعتبرهم الـFair Type ولي هم الـCommunist
+
+138
+00:13:31,070 --> 00:13:37,100
+اللي هي بتكون Multifactorialيعني بالنسبة للـGenes،
+
+139
+00:13:37,100 --> 00:13:39,440
+الـGenetic Involvement «هناك تجارب تجارب تجارب
+
+140
+00:13:39,440 --> 00:13:44,780
+تجارب» Definite، Familial، منتشر أكتر بين
+
+141
+00:13:44,780 --> 00:13:50,640
+الـFamilies بس بتكون مش جين واحد ولا مجموعة جينات،
+
+142
+00:13:50,640 --> 00:13:55,060
+يعني مجموعة جينات متفرقة بس مش في كرومزوم واحد ولا
+
+143
+00:13:55,060 --> 00:13:58,560
+في segment of the chromosome short arm، long arm
+
+144
+00:13:58,560 --> 00:14:03,560
+of a chromosome مثلا ولا كده، لأ ما بتكونفهي لما
+
+145
+00:14:03,560 --> 00:14:07,660
+تكون segment of many hundreds of thousands of
+
+146
+00:14:07,660 --> 00:14:15,100
+genes بتكون في الـChromosome الآن الـMicrobiome
+
+147
+00:14:15,100 --> 00:14:23,700
+يعني على كلمة genome –ome تعني اللي هي موضوع كل
+
+148
+00:14:23,700 --> 00:14:28,660
+الجينات تبعات الإنسان أو تبعات الخلية، أي خلية
+
+149
+00:14:28,660 --> 00:14:35,480
+بيكونيعني مثلًا نقول Cat Genome يعني للبس أجي أبحث
+
+150
+00:14:35,480 --> 00:14:42,320
+الـ DNA كله فالـ Genome هو وصف لكل الجينة فبنفس
+
+151
+00:14:42,320 --> 00:14:48,300
+الطريقة في طرق الآن نستخدم بيسموه الـ Microbiome
+
+152
+00:14:48,300 --> 00:14:57,050
+الـ Microbiome اللي هو بدرسه بشكل محدد أنواعالـ
+
+153
+00:14:57,050 --> 00:15:03,350
+Ribosomal RNA of the bacteria وبندرس، يعني بناخد
+
+154
+00:15:03,350 --> 00:15:09,090
+مثلاً سامبل من الـ Gut سامبل من الـ Skin بكتيريا
+
+155
+00:15:09,090 --> 00:15:13,610
+أو Gut بكتيريا أو Respiratory tract بكتيريا،
+
+156
+00:15:13,610 --> 00:15:20,950
+Mycosis وبندرس كل أنواع الـ RNA وRibosomal RNA
+
+157
+00:15:20,950 --> 00:15:25,640
+تبعتها فبنعرف الـ Species تبعت البكتيريافدراسة
+
+158
+00:15:25,640 --> 00:15:31,200
+كاملة لهذا الموضوع اسمها «microbiome» أحياناً الـ
+
+159
+00:15:31,200 --> 00:15:34,700
+«epigenetics» اللي هي «regulation of the genetics»
+
+160
+00:15:34,700 --> 00:15:39,740
+أي ما أنا ذكرته «metabolome» «metabolosome» اللي
+
+161
+00:15:39,740 --> 00:15:49,820
+هو أو «exposome» هو برضه طرق دراسة بشكل كامل مجمل
+
+162
+00:15:49,820 --> 00:15:56,030
+العوامل المؤثرة على الإنسانيعني مثلًا بالنسبة
+
+163
+00:15:56,030 --> 00:16:03,630
+لنوعية غذائنا شو من المكونات تبعته هي بشكل مجمل مش
+
+164
+00:16:03,630 --> 00:16:12,930
+بشكل فردي وشكل موحد فالـMicrobiome والـGenome
+
+165
+00:16:12,930 --> 00:16:17,910
+والـExposome لازم يعني المفاهيم اللي واحد يكون
+
+166
+00:16:17,910 --> 00:16:19,550
+عارفها ضروري يفهمها
+
+167
+00:16:22,810 --> 00:16:27,950
+سؤال السابع الـ
+
+168
+00:16:27,950 --> 00:16:34,510
+Somatic cells عكس الـ Gonads 97% من الـ DNA هو الـ
+
+169
+00:16:34,510 --> 00:16:40,770
+Nuclear DNA ويكون بالـ Nucleus الـ 3% يكون في
+
+170
+00:16:40,770 --> 00:16:47,570
+الميتوكندرية الميتوكندرية نفسها بالنسبة للـ A
+
+171
+00:16:47,570 --> 00:16:51,410
+طبعاً موجودة في الـ Botمايلز وفيميلز أنه
+
+172
+00:16:51,410 --> 00:16:54,450
+ميتوكندرية في كل خلية ففي جزء منها الـ
+
+173
+00:16:54,450 --> 00:16:58,970
+mitochondrial chromosomes وبتكون تبتد لحوالي 3% من
+
+174
+00:16:58,970 --> 00:17:03,890
+الـ DNA الـ mitochondrial chromosomes found in the
+
+175
+00:17:03,890 --> 00:17:07,710
+site of LASK الـ inheritance of mitochondrial DNA
+
+176
+00:17:07,710 --> 00:17:11,970
+is not similar لـ nuclear DNA، هذه الإجابة الـ
+
+177
+00:17:11,970 --> 00:17:17,010
+nuclear DNA نص من الأب ونص من الأم ال
+
+178
+00:17:17,010 --> 00:17:23,410
+mitochondrial DNAوكون فقط من طريق الأم الـ spare
+
+179
+00:17:23,410 --> 00:17:33,910
+مافي micro-conditioning ماشي و .. في طلاب طبعا
+
+180
+00:17:33,910 --> 00:17:44,270
+سؤال خمسة و انا و سؤال خمسة اه اذا
+
+181
+00:17:44,270 --> 00:17:56,630
+ال .. لما يكونproblem كثرة قلة عدم وجود تكرار كذا
+
+182
+00:17:56,630 --> 00:18:04,510
+لعدد كبير من الجينات نسميه chromosomal disease هذا
+
+183
+00:18:04,510 --> 00:18:11,210
+أقرب إشي، شايف عليه؟ segment معين، من داليا بدا
+
+184
+00:18:11,210 --> 00:18:15,530
+تكون one gene فقطكل الـExamples اللي كنت أعطيكوا
+
+185
+00:18:15,530 --> 00:18:19,490
+بيها مندليان، هي مندليان الـDown Syndrome، Client
+
+186
+00:18:19,490 --> 00:18:25,710
+Filter، Turner، أشياء زي هيك، هي الـChromosomal
+
+187
+00:18:25,710 --> 00:18:31,790
+Disease، هاي هي اللي بالسؤال، شو المشكلة؟ –أقصد
+
+188
+00:18:31,790 --> 00:18:37,210
+أنه ليش كل الـGenetic تطلع خطأ؟ –إيش هو؟ –ليش كل
+
+189
+00:18:37,210 --> 00:18:40,010
+الـGenetic تطلع خطأ، اللي هو الطيار دال؟ –كل
+
+190
+00:18:40,010 --> 00:18:44,690
+الـGeneticاللي هي لما الـ Disease مثلًا زي الربو
+
+191
+00:18:44,690 --> 00:18:53,310
+الربو بقدره إنه تقريبًا طبعًا الربو مثلًا فيه واضح
+
+192
+00:18:53,310 --> 00:18:58,630
+إنه فيه genetic factor يعني بتلاقي العيل أو
+
+193
+00:18:58,630 --> 00:19:02,930
+الإنسان المصاب في الغالب كمان في أعضاء تعائلته
+
+194
+00:19:02,930 --> 00:19:07,310
+مصابين أكثر من الـ General Population فبيعتبروا
+
+195
+00:19:07,310 --> 00:19:13,140
+هذا مؤشر على إنهفيه رولة جينية بس لما حاولوا
+
+196
+00:19:13,140 --> 00:19:17,080
+يعزلوا إيش الجين اللي بيعمل هذه المشكلة لقوم حوالي
+
+197
+00:19:17,080 --> 00:19:22,720
+خمسين جين وفي أماكن متفرقة فاهم عليك كده؟ يعني
+
+198
+00:19:22,720 --> 00:19:32,740
+الـIgE-Receptor جين Interleukin-4 نفسه Interleukin
+
+199
+00:19:32,740 --> 00:19:37,840
+-4-Receptor جين يعني في مجموعة جينات بتشترك في هذا
+
+200
+00:19:37,840 --> 00:19:42,680
+الموضوعوهدولة ما بيكونوا جنب بعض، ما بيكونوا مع
+
+201
+00:19:42,680 --> 00:19:48,960
+بعض فلما نكون، يعني لما أنت تيجي تاخد أنه أنا
+
+202
+00:19:48,960 --> 00:19:52,580
+بقولك أنه فيه عدد كبير من الجينات والمتوسط، هذا
+
+203
+00:19:52,580 --> 00:19:58,580
+سؤال راح ييجي بعدين أنه المتوسط عدد الجينات متوسط
+
+204
+00:19:58,580 --> 00:20:06,400
+في الـChromosome هو ألف جين أو مئات على الأقلفأقرب
+
+205
+00:20:06,400 --> 00:20:10,620
+شيء للـ Definition اللي مش Polygenic لما نقول
+
+206
+00:20:10,620 --> 00:20:16,720
+Polygenic المقصود فيه مجموعة جينات متعددة في أماكن
+
+207
+00:20:16,720 --> 00:20:21,600
+مختلفة مش هيك Signal ما بتكون على شكل Signal
+
+208
+00:20:21,600 --> 00:20:29,540
+فحاولت أحط الـ Definition كلمات أكتر عشان أوجه إنه
+
+209
+00:20:29,540 --> 00:20:35,550
+Chromosomal Disease مش Polygenicيعني هو صبعًا Poly
+
+210
+00:20:35,550 --> 00:20:41,250
+هي فيها عدد كبير بس مش هذا المفروض تبعها الـ
+
+211
+00:20:41,250 --> 00:20:45,030
+Polygenic بدخل فيها الـ Epigenetic يعني برضه
+
+212
+00:20:45,030 --> 00:20:51,730
+بتعتبر الـ Epigenetic والـ Polygenic متقاربة يعني
+
+213
+00:20:51,730 --> 00:21:00,470
+الـ Polygenicنتكلم عن ما يمكن يكون ميوتاشيا وطفرات
+
+214
+00:21:00,470 --> 00:21:05,190
+في نفس الجين اللي بسبب المرض بطريقة معينة والـ
+
+215
+00:21:05,190 --> 00:21:10,990
+Epigenetic هي طريقة تفعيله يعني بتلاقي اثنين
+
+216
+00:21:10,990 --> 00:21:17,090
+إنسانين، شخصين عندهم نفس الجين، في واحد شغال، في
+
+217
+00:21:17,090 --> 00:21:22,250
+واحد مش شغال هائل أو شغال كتير ومش شغال كتير،
+
+218
+00:21:22,250 --> 00:21:23,470
+هذولة Epigenetic
+
+219
+00:21:25,910 --> 00:21:31,790
+ماشي؟ إذا في أياسي لإسأله وخلّينا يعني مع الدكتور
+
+220
+00:21:31,790 --> 00:21:37,790
+ماني ماشي تحكولي، ماشي؟ دكتور يعني نفهم الـGeta
+
+221
+00:21:37,790 --> 00:21:42,350
+إنه طالما على أكتر من جين على نفس الـsegment
+
+222
+00:21:42,350 --> 00:21:44,710
+معناها كرمزومة أما إذا كانت أكتر من segment معناها
+
+223
+00:21:44,710 --> 00:21:49,710
+polygenetic، هيك المقصود؟ segment لما نقول عن
+
+224
+00:21:49,710 --> 00:21:55,200
+الـDNAيعني اللي هو الـ Bands و الـ و الـ
+
+225
+00:21:55,200 --> 00:22:00,540
+Chromosome نفسه الـ Big Arm و الـ Short Arm هدولة
+
+226
+00:22:00,540 --> 00:22:04,160
+بيكون فيهم Hundreds of Genes على الأقل أو Thousand
+
+227
+00:22:04,160 --> 00:22:08,140
+ماشي، فهدولة Chromosomal يعني الـ Chromosome هو
+
+228
+00:22:08,140 --> 00:22:12,920
+segment من الـ DNA إنه 64 Chromosome، 46
+
+229
+00:22:12,920 --> 00:22:19,020
+Chromosome و بيكون فيه مشكلة في واحد منهمفلما يكون
+
+230
+00:22:19,020 --> 00:22:23,540
+كل الـ Chromosome الـ Chromosome من 1 إلى 22 والـ
+
+231
+00:22:23,540 --> 00:22:28,740
+X والـ Y فبصير فيهم مشكلة، هذه اسمها Chromosomal
+
+232
+00:22:28,740 --> 00:22:36,980
+القريب منه مثلا في سؤال راح يجينا مريضة عندها، شو
+
+233
+00:22:36,980 --> 00:22:42,620
+اسمه؟ عندها، بتخلف الناس عندهم Down وصار عندها
+
+234
+00:22:42,620 --> 00:22:47,870
+Trisomy 21 إنه Translocationمن الـ Short-arm تبع
+
+235
+00:22:47,870 --> 00:22:51,390
+الـ ما هو فيه بعض الـ Short-arm مافيش فيها
+
+236
+00:22:51,390 --> 00:22:54,430
+كرموزومات كتير يعني هي قطعة من الـ chromosome
+
+237
+00:22:54,430 --> 00:22:59,890
+بتقول long أو short-arm زايدة، ناقصة، متغيرة، كده
+
+238
+00:22:59,890 --> 00:23:06,770
+فلما يكون definitely الـC والـD والـE والـA ما
+
+239
+00:23:06,770 --> 00:23:12,050
+بتظبط أقرب واحد لل definition اللي هو إنه اللي فيه
+
+240
+00:23:12,050 --> 00:23:16,170
+كرموزومة ماشي؟
+
+241
+00:23:22,680 --> 00:23:32,140
+سؤال تمانية ماشي الإجابة
+
+242
+00:23:32,140 --> 00:23:38,380
+Which statement about DNA is correct الـ backbone
+
+243
+00:23:38,380 --> 00:23:43,680
+هما الـ sugar و الـ phosphate الـ nitrogen base
+
+244
+00:23:43,680 --> 00:23:48,980
+اعتبرنا زي السلم في درجات السلم الـ nitrogen bases
+
+245
+00:23:49,990 --> 00:23:54,830
+الـ Sugar part، الـ DNA، الـ Deoxyribose، مش
+
+246
+00:23:54,830 --> 00:24:00,010
+Ribose الـ phosphate group alternates with the
+
+247
+00:24:00,010 --> 00:24:02,850
+sugar one in the backbone، هي الإيجابة الصحيحة
+
+248
+00:24:02,850 --> 00:24:07,090
+الأدينين والجوانين هم الـ Purines التايمين
+
+249
+00:24:07,090 --> 00:24:13,290
+والسايتوزين هم البريميدين، عكستهم، فهذه هي المفروض
+
+250
+00:24:13,290 --> 00:24:13,990
+أنها واضحة
+
+251
+00:24:17,370 --> 00:24:23,590
+لما نستخدم X-Ray Crystallography هذه الطريقة اللي
+
+252
+00:24:23,590 --> 00:24:29,510
+هي…–السؤال من نائل بالنسبة لسؤال سبعة نعم، الأولى
+
+253
+00:24:29,510 --> 00:24:36,290
+صح ليش، استنى علي أشوف سؤال سبعة أه، الأولى صح
+
+254
+00:24:36,290 --> 00:24:41,710
+طبعا الناقل،
+
+255
+00:24:41,710 --> 00:24:46,500
+يعني الـMitochondrial DNA موجودالـ Males و الـ
+
+256
+00:24:46,500 --> 00:24:49,560
+Females عندهم Mitochondria أي خلية Male و Female
+
+257
+00:24:49,560 --> 00:24:54,540
+فيها Mitochondria بس الـ الـ الوراثة تبعته هي اللي
+
+258
+00:24:54,540 --> 00:24:58,040
+فيها اختلاف الوراثة تبعته بالنسبة لـ Mitochondrial
+
+259
+00:24:58,040 --> 00:25:04,680
+DNA عن طريق الأم فقط لأن الـ الـ الـ Spare مافيه
+
+260
+00:25:04,680 --> 00:25:09,240
+Mitochondrial مافيه Mitochondrial ماشي اللي بيشترك
+
+261
+00:25:09,240 --> 00:25:14,460
+يعني اللي الطاقة في الـ Spare ماحتخده في منطقة الـ
+
+262
+00:25:14,460 --> 00:25:20,580
+Neckوالرأس تبعه اللي فيه الـ Tail فالـ Tail بتحرك
+
+263
+00:25:20,580 --> 00:25:25,580
+عشان يخلّي الـ Sperm يمشي بس الـ Mitochondria اللي
+
+264
+00:25:25,580 --> 00:25:29,120
+بدها طاقة موجودة في الـ Nucleus ما بتدخل في الـ
+
+265
+00:25:29,120 --> 00:25:35,660
+Fertilized egg لما يجي الـ Sperm يلقّع الـ يعني
+
+266
+00:25:35,660 --> 00:25:41,500
+الميتوكندريا الـ DNA موجودين في اثنين الميتوكندريا
+
+267
+00:25:41,500 --> 00:25:48,070
+والـ DNA تبعها موجودة بسبالنسبة للـ Inheritance
+
+268
+00:25:48,070 --> 00:25:52,770
+والاقتلاف فالسؤال
+
+269
+00:25:52,770 --> 00:25:59,310
+الإجابي إيه؟ هي جملة صحيحة ومش غلط أما الـ D هي
+
+270
+00:25:59,310 --> 00:26:05,310
+الغلط واضح؟
+
+271
+00:26:05,310 --> 00:26:08,370
+أنا هنا ما يعني ال male و ال female لازم يكون
+
+272
+00:26:08,370 --> 00:26:12,920
+عندهم mitochondria بس ال malesالـ Mitochondrial
+
+273
+00:26:12,920 --> 00:26:21,900
+تبعته ما بتنتقل للبنات ولأولاد كان من الأم فقط لما
+
+274
+00:26:21,900 --> 00:26:26,600
+نيجي نتفرج بالـ X-Ray Crystallography وقدنا نشوف
+
+275
+00:26:26,600 --> 00:26:31,620
+at a very يعني low level of my resolution الـ 2
+
+276
+00:26:31,620 --> 00:26:37,440
+نانومتر نشوف الـ Double Helix للـ DNA باستخدام الـ
+
+277
+00:26:37,440 --> 00:26:43,500
+X-Ray Crystallographyبيخلّوا المادة تلاقي الـ DNA
+
+278
+00:26:43,500 --> 00:26:50,720
+تأخذ شكل كريستال، ماشي، وبعدين they shine X-ray on
+
+279
+00:26:50,720 --> 00:26:55,720
+them وبيشوفوا كيف الـ reflection تبعتها، شو
+
+280
+00:26:55,720 --> 00:27:00,300
+الانطباع، شو الصورة راح تطلع، بيستنتجوا منها كيف
+
+281
+00:27:00,300 --> 00:27:04,240
+الـ structure تبع هذه البلّورة طبعاً بيخلّوه لازم
+
+282
+00:27:04,240 --> 00:27:11,850
+يتبلر، يصير على شكل بلّورةالـ average number of
+
+283
+00:27:11,850 --> 00:27:19,550
+genes per chromosome تقريبًا ألف يعني هيك بالمتوسط
+
+284
+00:27:19,550 --> 00:27:25,190
+في بعض الجينات very little زي الـ Y-chromosome
+
+285
+00:27:25,190 --> 00:27:30,770
+مافيش فيه كتير، قصير وصغير وبالنسبة مثلًا زي
+
+286
+00:27:30,770 --> 00:27:34,690
+chromosome 1 very large يمكن فيه حوالي 2000 gene
+
+287
+00:27:34,690 --> 00:27:44,960
+فالـ averageتقريبًا L يعني Recall بالنسبة للـ Cell
+
+288
+00:27:44,960 --> 00:27:53,680
+Cycle أو Cell Division Cycle بنقسمها G0 لما يكون
+
+289
+00:27:53,680 --> 00:28:00,580
+الخلايا بطلت تنقسم أو بدهاش تنقسم وملاجئها عادة
+
+290
+00:28:00,580 --> 00:28:05,360
+الخلايا المنقسمة لما تنقسم بتكون في مرحلة نسميها
+
+291
+00:28:05,360 --> 00:28:10,410
+G1يعني اللي هي الخلية العادية الخلية اللي بتكون
+
+292
+00:28:10,410 --> 00:28:16,490
+«between divisions» وبتقدر وظيفتها لما تقرر إنها
+
+293
+00:28:16,490 --> 00:28:22,470
+تنقسم أو اللي جيها أمر إنها تنقسم بتصير الـS-phase
+
+294
+00:28:22,470 --> 00:28:27,190
+اللي هي هنا
+
+295
+00:28:27,190 --> 00:28:30,870
+«all are through stages of self-divisional cycle
+
+296
+00:28:30,870 --> 00:28:37,440
+except» الـS-phase، لأ، هاي صح، أنا شو حطينا؟All
+
+297
+00:28:37,440 --> 00:28:41,880
+are true stages الـ G0 اللي هي when cells are not
+
+298
+00:28:41,880 --> 00:28:47,960
+dividing، صحيح الـ G1 الـ cells between divisions،
+
+299
+00:28:47,960 --> 00:28:55,740
+صحيح الـ S phase هي الـ
+
+300
+00:28:55,740 --> 00:28:59,080
+M phase when the cell division occurs، G2 phase
+
+301
+00:28:59,080 --> 00:29:03,200
+when cell prepares، صحيح
+
+302
+00:29:04,880 --> 00:29:09,360
+دكتور يا عفوا يا هذا السؤال كل إجابته صح أتوقع هيك
+
+303
+00:29:09,360 --> 00:29:14,920
+صحيح أنا خربطت في ال .. يعني كل اللي بيطلع عن
+
+304
+00:29:14,920 --> 00:29:19,740
+الجوابات صحيح يعني نعم ماشي يعني يعني يا دكتور هذا
+
+305
+00:29:19,740 --> 00:29:24,340
+.. هذا بنشيله يعني إيش يعني .. ماشي هذا بنشيله هذا
+
+306
+00:29:24,340 --> 00:29:28,820
+بنشيله مافي مشكلة أه دكتور أحمد؟ تمام ان شاء الله
+
+307
+00:29:28,820 --> 00:29:34,660
+بنخدف السؤال ما .. ما تقلبك أه ماشياللي أنا
+
+308
+00:29:34,660 --> 00:30:02,180
+بكون…………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………�
+
+309
+00:30:02,540 --> 00:30:06,400
+دكتور بنفع تخليه bonus بدل ما تحزفه لأنه ضيع نوجت
+
+310
+00:30:06,400 --> 00:30:08,720
+و احنا بنستلقع في السؤال يمكن نقعدنا تلت دقايق او
+
+311
+00:30:08,720 --> 00:30:11,700
+اكتر و احنا بنتحيرنا في السؤال ازاي أنا بالنسبة
+
+312
+00:30:11,700 --> 00:30:17,900
+لدكتور أحمد بشوفي دكتور أحمد اسمع علي كداش ال
+
+313
+00:30:17,900 --> 00:30:21,680
+average و كداش ال standard deviation شوق على علامة
+
+314
+00:30:21,680 --> 00:30:27,080
+و أوطة علامة للأسف يعني في من ناحية أوطة علامة في
+
+315
+00:30:27,080 --> 00:30:32,840
+يعنيثمن طلاب تحت الخمستاش أعلى علام تسعة و عشرين
+
+316
+00:30:32,840 --> 00:30:37,300
+محدش جاب تلاتين تسعة
+
+317
+00:30:37,300 --> 00:30:41,440
+و عشرين من خمسين تسعة و عشرين من تلاتين تسعة و
+
+318
+00:30:41,440 --> 00:30:41,600
+عشرين من تلاتين تسعة و عشرين من تلاتين تسعة و
+
+319
+00:30:41,600 --> 00:30:43,360
+عشرين من تلاتين تسعة و عشرين من تلاتين تسعة و
+
+320
+00:30:43,360 --> 00:30:44,800
+عشرين تلاتين تسعة و عشرين تلاتين تسعة و عشرين
+
+321
+00:30:44,800 --> 00:30:48,240
+تلاتين تسعة و عشرين تلاتين تسعة و عشرين تلاتين
+
+322
+00:30:48,240 --> 00:30:51,420
+تسعة و عشرين تلاتين تلاتين تلاتين تلاتين تلاتين
+
+323
+00:30:51,420 --> 00:30:52,340
+تلاتين تلاتين تلاتين تلاتين تلاتين تلاتين تلاتين
+
+324
+00:30:52,340 --> 00:30:59,540
+تلاتين تلاتين تلوالله بدك تخليه خليه الـ Average
+
+325
+00:30:59,540 --> 00:31:05,520
+إذا يعني أنا شايف هيك يعني فيه good distribution
+
+326
+00:31:05,520 --> 00:31:10,440
+يعني معناته الأسئلة أنا بشوف إن الأسئلة كانت بشكل
+
+327
+00:31:10,440 --> 00:31:14,940
+عام مقبولة فيه كتير علامات كاملة كان فيها تقريبا
+
+328
+00:31:14,940 --> 00:31:18,580
+يعني فيه عدد أسئلة كويس وفيها أسئلة كان فيها خربطة
+
+329
+00:31:19,110 --> 00:31:26,170
+يعني يمكن هذا السؤال اللي يمكن خربط الطلاب على كله
+
+330
+00:31:26,170 --> 00:31:30,550
+شوف إدارة الكلية أنا ماعندي مشكلة خلّيه bonus إذا
+
+331
+00:31:30,550 --> 00:31:37,650
+كان بدك تعتبره هيك تعيد التصليح و تخليه أو تحذفه و
+
+332
+00:31:37,650 --> 00:31:41,190
+تعيد التصليح مرة تانية برضه بيصير يعني bonus،
+
+333
+00:31:41,190 --> 00:31:47,270
+bonus أكثر، bonus أكثر ماشي، ماشيماشي إن شاء الله
+
+334
+00:31:47,270 --> 00:31:50,750
+بالنسبة
+
+335
+00:31:50,750 --> 00:31:55,550
+للـ Stages، الـ Cell Division هذه يعني، بالذات لما
+
+336
+00:31:55,550 --> 00:32:01,130
+واحد يرجع للتبعات الـ USMLE بتلاقي في عليها أسئلة
+
+337
+00:32:01,130 --> 00:32:08,330
+و لازم الواحد يحفظهم و بنتي علمتني بيقولها P-Math
+
+338
+00:32:08,330 --> 00:32:14,430
+ماشي؟ اللي إن حتى الواحد يحفظ الـ Stages ماشي؟
+
+339
+00:32:16,350 --> 00:32:22,270
+بالأول الـ Prophase، Metaphase أول شي Prophase،
+
+340
+00:32:22,270 --> 00:32:25,270
+بعدين Pro-Metaphase، بعدين Metaphase، Anaphase،
+
+341
+00:32:25,270 --> 00:32:32,690
+Telophase، فبالأخير MAD وبالأول P، P، P، P، MAD
+
+342
+00:32:32,690 --> 00:32:37,630
+فالآن which stage of cell division by mitosis
+
+343
+00:32:38,240 --> 00:32:43,140
+بالتالي كان هناك مبنى نوكليار والـ Centromere لسه
+
+344
+00:32:43,140 --> 00:32:49,340
+هي أول واحدة أول بداية فتكون الـ Prophase البقية
+
+345
+00:32:49,340 --> 00:32:53,840
+مايكونش فيه مبنى نوكليار الـ Centromere الـ
+
+346
+00:32:53,840 --> 00:32:59,420
+Centrosome بيكون موجود ويبدأ يتكون حتى يفصل
+
+347
+00:32:59,420 --> 00:33:06,400
+الكرمزومات عن بعض هذه
+
+348
+00:33:06,400 --> 00:33:07,320
+الـ Prophase
+
+349
+00:33:10,580 --> 00:33:14,700
+الأن الـ «Chromosomes are arranged in the middle
+
+350
+00:33:14,700 --> 00:33:18,400
+with microtubules directing them to the central
+
+351
+00:33:18,400 --> 00:33:22,100
+zones» اللي هي بتبدأ في حالة الـ «Metaphase» لما
+
+352
+00:33:22,100 --> 00:33:26,960
+تترتب في هذه الشغل بعدين بيبدو ينشدوا على الجهتين
+
+353
+00:33:26,960 --> 00:33:31,020
+وينفصلوا الـ «Anaphase» وبس يخلص يبتدلوا «Phase»
+
+354
+00:33:31,020 --> 00:33:33,360
+ترجع الـ «Nuclear Membrane» تنفصل
+
+355
+00:33:36,720 --> 00:33:42,080
+الـ Usual Karyotyping و Binding of chromosomes الـ
+
+356
+00:33:42,080 --> 00:33:49,860
+Right Stain بالنسبة لنا نستخدمه زي نلسان للـ TD
+
+357
+00:33:49,860 --> 00:33:52,940
+همتوكسلينيوسين
+
+358
+00:33:52,940 --> 00:33:58,300
+للـ Stain والـ Gram Stain للبكتيريا، ماعناش دخل
+
+359
+00:33:58,300 --> 00:34:02,380
+الـ Right Stain للـ Red و Blood Cell و الـ
+
+360
+00:34:02,380 --> 00:34:05,360
+Hematology بس اللي بيستخدم الـ Gemma Stain
+
+361
+00:34:09,510 --> 00:34:13,390
+بالنسبة لـ stage of cell division الـ two gametes
+
+362
+00:34:13,390 --> 00:34:18,130
+at the end of meiosis بكون اللي هي الـ Anaphase 2
+
+363
+00:34:18,130 --> 00:34:23,090
+حتى
+
+364
+00:34:23,090 --> 00:34:27,530
+أنا يعني طبعاً بدنا نلاحظ الـ meiosis فيه two
+
+365
+00:34:27,530 --> 00:34:33,500
+stages Stage 1 و Stage 2فالواحد في بعضها حطيت يعني
+
+366
+00:34:33,500 --> 00:34:38,680
+يمكن كانت لو في تيلو phase two يمكن أظبط أحسن أقرب
+
+367
+00:34:38,680 --> 00:34:44,440
+بين الأنا والتيلو بالأخير بس لازم كتو أنا phase
+
+368
+00:34:44,440 --> 00:34:49,160
+two مش الـmetaphase ولا الـbrometaphase الـphase
+
+369
+00:34:49,160 --> 00:34:55,980
+one ما بيكونش بنقسم لتو جميت لسه في الـG2 phase
+
+370
+00:34:55,980 --> 00:35:01,600
+الـDNA content is 4L normallyخلّيه لما بدأ تنقسم
+
+371
+00:35:01,600 --> 00:35:07,020
+بالـG2 بالـMyotosis
+
+372
+00:35:07,020 --> 00:35:13,680
+بدأ تكون شو اسمه؟ 4M يعني صار الـS-Phase وصار
+
+373
+00:35:13,680 --> 00:35:18,380
+الـDuplication للـDNA لأن
+
+374
+00:35:18,380 --> 00:35:24,970
+all are true statements about the genomeالكثيرية
+
+375
+00:35:24,970 --> 00:35:28,170
+العامة من الـ DNA في جسد الإنسان هي الـ Coding
+
+376
+00:35:28,170 --> 00:35:33,590
+للبروتينات المهمة، لأ 4، 5% بس في الـ Human Genome
+
+377
+00:35:33,590 --> 00:35:38,790
+وهذا عكس كثير من الكائنات الحي الأخرى يعني هذا
+
+378
+00:35:38,790 --> 00:35:43,390
+الجانب يمكن الواحد جيد إن يطلع عليه الكائنات
+
+379
+00:35:43,390 --> 00:35:51,660
+الثانية يعني الـ DNA أو المادة الوراثية سبعتهاحتى
+
+380
+00:35:51,660 --> 00:35:57,880
+تستخدم بشكل كثيف لإنتاج البروتينات واللي يكون
+
+381
+00:35:57,880 --> 00:36:03,300
+coding الـDNA بينما الإنسان من الكائنات، يعني
+
+382
+00:36:03,300 --> 00:36:06,860
+الأشياء اللي بيكون فيها الـnon-coding هو
+
+383
+00:36:06,860 --> 00:36:13,800
+الـmajority الـGenes are transcribed وبعدين
+
+384
+00:36:13,800 --> 00:36:18,880
+manipulated بالـSplicing عشان الـMessenger RNA
+
+385
+00:36:20,150 --> 00:36:25,410
+باستخدام إزالة الـ Intron صحيحة الـ Messenger RNA
+
+386
+00:36:25,410 --> 00:36:32,910
+تترجم إلى البروتينات صحيح الترجمة حصلت في النوكليا
+
+387
+00:36:32,910 --> 00:36:37,390
+والترجمة في مكان الأرض صحيح الـ Polypeptide Chains
+
+388
+00:36:37,390 --> 00:36:42,130
+تم تغييرها بعد ذلك بإزالة الجلد والميكانيزمات
+
+389
+00:36:42,130 --> 00:36:49,270
+الصحيحة فهذه كل جمل صحيحة ما كانت الأولى الآن
+
+390
+00:36:51,110 --> 00:36:56,870
+كلها اختلافات حقيقية إلا أن الفوسفات هي نفسها
+
+391
+00:36:56,870 --> 00:37:03,130
+الاختلاف في الـ DNA، الشجر هو ديوكسي، ليس الريبوز
+
+392
+00:37:03,130 --> 00:37:08,550
+في الـUracil والثامين، فيه اختلاف بينهم الـ DNA
+
+393
+00:37:08,550 --> 00:37:14,230
+دائماً عاديةً مجموعة مدعومة بس فيه مجموعة مدعومة
+
+394
+00:37:14,230 --> 00:37:18,530
+DNA ممكن نصنع، ممكن بعض الفيروسات فيها مجموعة
+
+395
+00:37:18,530 --> 00:37:23,420
+مدعومة DNA، تصيربس الـ most of the DNA is double
+
+396
+00:37:23,420 --> 00:37:27,300
+-stranded و الـ most of the RNA is single
+
+397
+00:37:27,300 --> 00:37:32,020
+-stranded، هيك بسيطة either can be the genetic
+
+398
+00:37:32,020 --> 00:37:36,040
+source of living material، صحيح ذات الـ viruses
+
+399
+00:37:36,040 --> 00:37:43,520
+بعضهم DNA viruses بعضهم RNA virus يعني، بالتالي،
+
+400
+00:37:43,520 --> 00:37:50,040
+can be for both، ماشي؟ فالـ phosphate group مافي
+
+401
+00:37:50,040 --> 00:37:50,860
+اختلاف تاني
+
+402
+00:37:54,290 --> 00:37:58,590
+بالنسبة لـ All are true statements about reading
+
+403
+00:37:58,590 --> 00:38:03,830
+the DNA into finally proteins الـ Always read from
+
+404
+00:38:03,830 --> 00:38:09,790
+five prime to three prime direction صحيح لأنه
+
+405
+00:38:09,790 --> 00:38:16,530
+في عنا twenty different amino acids وعندي four
+
+406
+00:38:16,530 --> 00:38:19,390
+nitrogen bases ماشي
+
+407
+00:38:21,150 --> 00:38:27,250
+يعني بيعطيني أربعة nucleotides فلازم يكون كل ثلاثة
+
+408
+00:38:27,250 --> 00:38:31,370
+مع بعض يعني مش four nucleotides are used to
+
+409
+00:38:31,370 --> 00:38:35,670
+indicate the amino acid لازم three nucleotides are
+
+410
+00:38:35,670 --> 00:38:40,370
+used to indicate the amino acid نسميها triplets أو
+
+411
+00:38:40,370 --> 00:38:47,590
+الـ Codon فالـ
+
+412
+00:38:47,590 --> 00:38:55,030
+B هي الغلطماشي يعني عشان أغطي عشرين amino acid و
+
+413
+00:38:55,030 --> 00:38:59,050
+start و stop يعني او واحد عشرين amino acid أو
+
+414
+00:38:59,050 --> 00:39:02,970
+عشرين amino acid و ال start و ال stop هدولة صاروا
+
+415
+00:39:02,970 --> 00:39:09,430
+تلاتة و عشرين أو اتنين و عشرين message بديها أو
+
+416
+00:39:09,430 --> 00:39:19,110
+أقدر أحددها فاللي لازم يكون على أقل تلاتة basesلأ،
+
+417
+00:39:19,110 --> 00:39:24,170
+دي هي الـNucleotides لأنه أربعة أقصد ثلاث بيسووا
+
+418
+00:39:24,170 --> 00:39:30,930
+أربعة وستين يعني أربعة في أربعة في أربعة أربعة
+
+419
+00:39:30,930 --> 00:39:35,730
+وستين وأربعة وستين بتغطي العشرين طبعاً معناته إنه
+
+420
+00:39:35,730 --> 00:39:42,630
+بعض الـAmino Acids بيكون أكتر من Sequence بيغطيهم
+
+421
+00:39:42,630 --> 00:39:47,770
+يعني مش واحد لواحد تماماً ففيه جدوة اللي فرجتكم
+
+422
+00:39:47,770 --> 00:39:54,400
+اليومالجدول، خلّيني أدخل لـ «دكتور، بس given
+
+423
+00:39:54,400 --> 00:39:59,040
+الجدول، فيه سؤال، يعني فيه أسئلة بخصوص السؤال 12»
+
+424
+00:39:59,040 --> 00:40:04,860
+«12» «متعلق بقضية الـ stages أعتقد، في محمد بيقول
+
+425
+00:40:04,860 --> 00:40:09,100
+الـ Bromephase» «هو ليس لديه سينتروزومات، بدأت في
+
+426
+00:40:09,100 --> 00:40:17,880
+الـ Brometaphase» لأ، ال .. شو اسمه؟ سؤال رقم 12
+
+427
+00:40:21,490 --> 00:40:28,910
+بداية الـ Cell Division، ماشي؟ إحنا خلّينا الـ
+
+428
+00:40:28,910 --> 00:40:32,330
+Bromata Phase بيكون فيها Nuclear Membrane و لا
+
+429
+00:40:32,330 --> 00:40:38,670
+مافيش Nuclear Membrane؟ خلّيه يراجع الصورة، ماشي؟
+
+430
+00:40:38,670 --> 00:40:47,250
+يعني أنا السمرات إحنا لما نصف الحركات أو الـ Steps
+
+431
+00:40:47,840 --> 00:40:53,620
+يعني وجود الـ Centrosome تكوينه بتزامن تقريبًا
+
+432
+00:40:53,620 --> 00:40:58,260
+يمكن، ماعرفش، يعني ما بيقدرش الواحد يعني يحط حد
+
+433
+00:40:58,260 --> 00:41:04,840
+فاصل تمامًا بس الـ Prophase بالأول بيكون بداية
+
+434
+00:41:04,840 --> 00:41:11,280
+تكون يعني الـ Mitosis بعد ما الخلية دوبلت الـ DNA
+
+435
+00:41:11,280 --> 00:41:15,320
+تبعها يعني بالأول في الـ S-phase لما اتقررت، يعني
+
+436
+00:41:15,320 --> 00:41:20,130
+لما بدأت تقرر تنقسمبالأول بتكرر الـ DNA تبعها،
+
+437
+00:41:20,130 --> 00:41:25,790
+الجهد بعدين تبدأ تشتغل، فتدخل بالـ Pro-phase لما
+
+438
+00:41:25,790 --> 00:41:29,350
+يكون لسه فيه Nuclear Membrane الوحيد اللي في الصور
+
+439
+00:41:29,350 --> 00:41:31,770
+كلها اللي فيها Nuclear Membrane هو الـ Pro-phase
+
+440
+00:41:31,770 --> 00:41:37,750
+الـ Pro-metaphase والـ Metaphase، لأ مافيش Nuclear
+
+441
+00:41:37,750 --> 00:41:41,270
+Membrane فاختفاء الـ Nuclear Membrane أنا أخدته
+
+442
+00:41:41,270 --> 00:41:45,710
+إنه الـ Pro-metaphase ف… وبيبدأ من أول شيء يتشكل
+
+443
+00:41:45,710 --> 00:41:54,470
+الـ Centrosomeيعني هسا اللي خدها أقوى يعني بالنسبة
+
+444
+00:41:54,470 --> 00:41:59,990
+للـ «نوكليار ممبرين» اللي هو إنه طبعاً بالـ
+
+445
+00:41:59,990 --> 00:42:06,630
+«بروفيس» بكون لسه موجود ماشي، اتطلع الصورة وشوفها،
+
+446
+00:42:06,630 --> 00:42:07,490
+ماشي
+
+447
+00:42:11,980 --> 00:42:20,220
+بتكم ناخذ اللي هي Human Genome خلّيني بس أفرج،
+
+448
+00:42:20,220 --> 00:42:26,880
+أطلّع الصورة تبعتها هاي
+
+449
+00:42:26,880 --> 00:42:30,180
+وبعدين،
+
+450
+00:42:30,180 --> 00:42:34,640
+هاي، ثواني خلّيني أسوي لكم share بعد شوية بس،
+
+451
+00:42:34,640 --> 00:42:45,460
+ثواني على الـ… هايطيب، هاي هونا الـ Genetic
+
+452
+00:42:45,460 --> 00:42:52,820
+Diversity نعم،
+
+453
+00:42:52,820 --> 00:43:00,980
+مش هذه هاي
+
+454
+00:43:00,980 --> 00:43:04,480
+طبعاً Psychogenetics
+
+455
+00:43:15,530 --> 00:43:23,570
+وين راحت مش شايف الصورة هسه لو أنا human genome
+
+456
+00:43:55,820 --> 00:44:07,780
+أخر مرة أشوف هذه سبحان
+
+457
+00:44:07,780 --> 00:44:15,180
+الله كيف لما بدك إشي ما بتلاقيهوش المهم ارجع للـ
+
+458
+00:44:15,180 --> 00:44:25,180
+بالنسبة لـالترتيب هذا، اتطلع على الصورة ويعني أنا
+
+459
+00:44:25,180 --> 00:44:33,020
+أظن الكلام واضح بالنسبة لـ الـ الكلام واضح بالنسبة
+
+460
+00:44:33,020 --> 00:44:39,700
+لـ الـ Stage اللي هي يعني ركز على موضوع اللي هو
+
+461
+00:44:39,700 --> 00:44:44,400
+وجود الـ Cell Membrane مش عارف عليه؟ آسف الـ
+
+462
+00:44:44,400 --> 00:44:47,650
+Nuclear Membraneالـ Stage الوحيد اللي فيها Nuclear
+
+463
+00:44:47,650 --> 00:44:56,230
+Membrane هي الـ Prophase الـ بالنسبة لـ الآن
+
+464
+00:44:56,230 --> 00:45:07,270
+السؤال على الـ اللي هو أظن 1917 بالكوانين الآن
+
+465
+00:45:07,270 --> 00:45:16,360
+بس بنذبحكم على شغل بالنسبة لسؤال 19 ماشييعني
+
+466
+00:45:16,360 --> 00:45:26,020
+بالنسبة هنا هاي الـShare بالنسبة
+
+467
+00:45:26,020 --> 00:45:29,860
+لترتيب الـ…
+
+468
+00:45:29,860 --> 00:45:36,460
+بالنسبة لترتيب الـ… إنه Amino Acids وTriplets كيف؟
+
+469
+00:45:36,460 --> 00:45:41,940
+وAnode coding for what؟ وكده فبدأ أطلب منكم
+
+470
+00:45:41,940 --> 00:45:52,860
+تتذكروا شغلة اللي هيصراحة لقيتها في USMLE
+
+471
+00:45:52,860 --> 00:46:00,960
+وغيره الآن هذه الجدول اللي احنا شوفناها والـ First
+
+472
+00:46:00,960 --> 00:46:06,480
+Base هي الـ U وC وA وG وهذه الـ Second Base اللي
+
+473
+00:46:06,480 --> 00:46:16,020
+هي الـ U وC وA وG وهذه الـ Third Base هنا فكل
+
+474
+00:46:16,020 --> 00:46:20,500
+ثلاثية هو أنا بعطيكم شو الـ Amino Acid تبعها
+
+475
+00:46:20,500 --> 00:46:27,800
+فالفنع الأنالين الـ UUU أو UUC مثلا، يمكن يكون في
+
+476
+00:46:27,800 --> 00:46:34,900
+غيرهم، ماشي؟ الأشياء اللي لاحظته مركزين عليه ويله
+
+477
+00:46:34,900 --> 00:46:36,420
+تأثير في
+
+478
+00:46:38,900 --> 00:46:43,940
+يعني له تأثير في قضية بعض الحالات وبعض الأمراض
+
+479
+00:46:43,940 --> 00:46:50,580
+اللي حطينا اللي هو الـ «UAA»
+
+480
+00:46:50,580 --> 00:46:55,020
+و «UAG» أنا ماكنتش حافظهم أو عمري ماحفظتهم أيه بس
+
+481
+00:46:55,020 --> 00:47:00,900
+مش غلط الواحد يتذكر «UAA» أو «UAG» هاي الـ «Stock
+
+482
+00:47:00,900 --> 00:47:10,770
+Codon» و «UGA» هاي تلافة ماشيهدولة ثلاثة sequences
+
+483
+00:47:10,770 --> 00:47:19,470
+بتاعني stop ماشي فهدولة لما ييجيوكم مش عارف كيف
+
+484
+00:47:19,470 --> 00:47:28,050
+الواحد يحفظها UAA UGA UAG يعني هدولة أولها U
+
+485
+00:47:28,050 --> 00:47:34,450
+وآخرها G وA هدولة بمعنى stopلما يحكوا لك ويديبوا
+
+486
+00:47:34,450 --> 00:47:42,610
+لك قصة وفيه سؤال جبته إنه فيه بالأخير خلل فيه إنه
+
+487
+00:47:42,610 --> 00:47:47,130
+صار إشي بدل إشي بحيث إنه اتكونت واحدة من هدولة
+
+488
+00:47:47,130 --> 00:47:55,090
+التلاتة بتخلي إنه يصير عند الحالة بيصير يعني بيصير
+
+489
+00:47:55,090 --> 00:47:58,510
+stop
+
+490
+00:47:58,510 --> 00:48:04,540
+reading of theالبروتين أو التكوين للبروتين بيوقف
+
+491
+00:48:04,540 --> 00:48:12,880
+في مرحلة مش طبيعية فهي ناحية مهمة بس خلّيني أشوف
+
+492
+00:48:12,880 --> 00:48:25,200
+وين راحت هذه الصورة فالآن
+
+493
+00:48:25,200 --> 00:48:30,970
+بالنسبة للسؤال اللي سألوا زميلكميعني احنا المهم
+
+494
+00:48:30,970 --> 00:48:37,730
+بدل واحد يتذكر فيه P-MAT أو P-MAT فالـ Chrome
+
+495
+00:48:37,730 --> 00:48:42,570
+الصورة هنا الـ Prophets فيه Nuclear Membrane هي
+
+496
+00:48:42,570 --> 00:48:46,890
+الوحيد اللي فيها Nuclear Membrane لسه ما اتحطمش
+
+497
+00:48:46,890 --> 00:48:51,810
+بعد ما كثرت الـ DNA تبعها والـ Central Zones هي
+
+498
+00:48:51,810 --> 00:49:00,830
+الموجودينفالسؤال الأتناش، شو اسمه؟ السؤال الأتناش
+
+499
+00:49:00,830 --> 00:49:09,370
+صحيح ويعني هي الموجودة، ماشي الـ
+
+500
+00:49:09,370 --> 00:49:16,490
+Epigenetic Mechanisms main point إنه they are
+
+501
+00:49:16,490 --> 00:49:21,710
+difficult to understand and difficult to studyيعني
+
+502
+00:49:21,710 --> 00:49:27,570
+الـ Mechanisms تبعتها للآن ما استقر الإلم عليها
+
+503
+00:49:27,570 --> 00:49:36,190
+بشكل واضح، كامل، مبسط، سهل، كده They are needed to
+
+504
+00:49:36,190 --> 00:49:40,390
+control which genes are activated in each type of
+
+505
+00:49:40,390 --> 00:49:47,310
+cell، صحيح كل الجينات تبعت كل الخلايا في جسم
+
+506
+00:49:47,310 --> 00:49:52,190
+الإنسان زي بعض اللي بيفرق خلية عن خليةأنه الجين
+
+507
+00:49:52,190 --> 00:49:56,230
+اللي اشتغل في هذه الكلمة؟ كيف هذا الجين بيشتغل أو
+
+508
+00:49:56,230 --> 00:50:00,850
+مابيشتغلش؟ هذا الـ Epigenetic Mechanism فهي صعبة
+
+509
+00:50:00,850 --> 00:50:07,150
+تدرس و تفهمها الـ Genetic Imprinting أو الـ
+
+510
+00:50:07,150 --> 00:50:11,230
+Parental Imprinting هذا والله للآن ماني فاهمه،
+
+511
+00:50:11,230 --> 00:50:15,530
+ماشي؟ بس هو Epigenetic Mechanism يصير عندنا DNA
+
+512
+00:50:15,530 --> 00:50:20,280
+Mutilation Testosterone Variation وMutilationوالـ
+
+513
+00:50:20,280 --> 00:50:25,200
+Genetic Imprinting كلهم ميكانيزم للـ Epigenetic
+
+514
+00:50:25,200 --> 00:50:30,260
+Mechanism اللي هما يعني مش في الـ Coding DNA هدولة
+
+515
+00:50:30,260 --> 00:50:34,900
+في الـ Controlling DNA أو Controlling Mechanism
+
+516
+00:50:34,900 --> 00:50:42,060
+للـ Expression ماشي، في أسئلة؟
+
+517
+00:50:42,060 --> 00:50:45,360
+الآن في موضوع اتكلمنا عنه اسمه الـ Allelic
+
+518
+00:50:45,360 --> 00:50:53,220
+Expression اللي هو أنهالذي يتم إظهاره الأليل وإذا
+
+519
+00:50:53,220 --> 00:50:57,400
+كان هناك إثنين أليل فهو يجب أن يتم إظهاره الأليل
+
+520
+00:50:57,400 --> 00:51:03,720
+أحياناً تكون جينات معينة أن كلا الأليل تم إظهارهم
+
+521
+00:51:03,720 --> 00:51:09,300
+بشكل متساوي صحيح في أحيان بيحصل اسمه أشياء أليلة
+
+522
+00:51:09,300 --> 00:51:12,580
+في الانفجار يعني يكون عنده أشياء مختلفة
+
+523
+00:51:25,250 --> 00:51:30,310
+الخيار الأول كأنه بيقول ان ال expression خمسين
+
+524
+00:51:30,310 --> 00:51:34,850
+خمسين بالنية الخيار الثاني صفر ومية
+
+525
+00:51:37,460 --> 00:51:41,260
+أحيانًا ما بتكون في هالـ Two extremes خمسين وخمسين
+
+526
+00:51:41,260 --> 00:51:46,200
+أو صفر ومية مرات سبعين وثلاثين، ستين واربعين
+
+527
+00:51:46,200 --> 00:51:50,580
+مثلًا، فابدى أسموه Unbalanced expression which
+
+528
+00:51:50,580 --> 00:51:54,920
+occurs in early embryogenesis صحيحة، in females
+
+529
+00:51:54,920 --> 00:51:58,520
+الـ X chromosome inactivation randomly occurs
+
+530
+00:51:58,520 --> 00:52:03,640
+صحيح، وSomatic mutations which is a cause of
+
+531
+00:52:03,640 --> 00:52:10,320
+allylic expression variation برضه صحيحةبالنسبة للـ
+
+532
+00:52:10,320 --> 00:52:16,760
+Mutations لما ندرس الـ Genome الـ Most Common في
+
+533
+00:52:16,760 --> 00:52:23,520
+أي خلية تقريبًا عن الـ Standard بيكون حوالي 5 إلى
+
+534
+00:52:23,520 --> 00:52:28,980
+10 مليون اللي هم Single Nucleotide Polymorphism
+
+535
+00:52:28,980 --> 00:52:34,040
+هدولة لما نسيروا ما بيقدّوا لهذا الشيء مرات كثيرة
+
+536
+00:52:34,040 --> 00:52:39,080
+خصوصًا إنه ممكن هذا يحدث في منطقة Non-codingيعني
+
+537
+00:52:39,080 --> 00:52:45,180
+ما لهاش قيمة يعني في بعضهم في عندنا Frame Shift
+
+538
+00:52:45,180 --> 00:52:50,000
+Type Deletion Type Inversion Type Copy Number
+
+539
+00:52:50,000 --> 00:52:55,260
+Variation Type هدولة Different Forms of Variation
+
+540
+00:52:55,260 --> 00:52:59,680
+بس أقوى أشي أكتر أشي حدوثًا اللي هو Single
+
+541
+00:52:59,680 --> 00:53:06,960
+Nucleotide Polymorphism الآن إذا صار عندي Deletion
+
+542
+00:53:06,960 --> 00:53:13,940
+أو Insertionإذا ثلاثات أو مضاعفاتها ما لها قيمة
+
+543
+00:53:13,940 --> 00:53:18,400
+كبيرة ما بيأثر كثير على البروتين النهائي بس لما
+
+544
+00:53:18,400 --> 00:53:21,700
+يصير عندي deletion أو insertion لـ one أو two
+
+545
+00:53:21,700 --> 00:53:28,960
+nucleotides هذا هو المشكلة إذا ثلاثة يعني بضيف
+
+546
+00:53:28,960 --> 00:53:35,220
+amino acid ففي الغالب البروتين بتحمل وممكن يكون
+
+547
+00:53:35,220 --> 00:53:45,500
+يعني في منطقة مش مؤثرة ماشيف6 و0 و3 ومضاعفاتها ما
+
+548
+00:53:45,500 --> 00:53:54,420
+في مشكلة بس 1 و2 هي اللي فيها المشكلة ماشي الحال؟
+
+549
+00:53:54,420 --> 00:54:01,500
+لما ندرس الـ Single-Newt Cleotide Polymorphism
+
+550
+00:54:01,500 --> 00:54:08,020
+يعني خلّينا نتذكر كلمةلما أريد أن أدرس كـ
+
+551
+00:54:08,020 --> 00:54:14,240
+Chromosome، Anomaly، Turner-Klein Filter، كذا،
+
+552
+00:54:14,240 --> 00:54:19,920
+تعمل شيء يسمونه كـ Karyotype لما أريد أن أدرس على
+
+553
+00:54:19,920 --> 00:54:24,420
+Single Nucleotide Polymorphism لازم أعمل Sequence
+
+554
+00:54:24,420 --> 00:54:30,360
+with PCR Reaction ماشي، Polymerase Chain Reaction
+
+555
+00:54:30,360 --> 00:54:37,650
+فهذه الـالـ «سيجمان»
+
+556
+00:54:37,650 --> 00:54:45,330
+فيها غلط بالكتابة، ماشي الـ sequencing of the DNA
+
+557
+00:54:45,330 --> 00:54:51,330
+الـ «BF» غلط، مش مفروض يكون هناك، ظهر بالتباعة
+
+558
+00:54:51,330 --> 00:54:58,270
+يعني الكاريوتيب ما بيظبط فيكي، بدرسش كبير الـ
+
+559
+00:54:58,270 --> 00:55:05,000
+Fluorescentوالـ Microsatellites
+
+560
+00:55:05,000 --> 00:55:12,700
+وحتى الـ Routine Banding ماشي هدولة مثلا زي Dijard
+
+561
+00:55:12,700 --> 00:55:17,800
+Syndrome زي يعني بيكون فيها segment كبير ما بيكون
+
+562
+00:55:17,800 --> 00:55:25,680
+تقدر تكشفني على Single Nucleotide Polymerism آه،
+
+563
+00:55:25,680 --> 00:55:31,910
+في سؤال؟ في سؤال منمهم في سؤال بيقول ليش ما عملنا
+
+564
+00:55:31,910 --> 00:55:36,670
+الـ FISH الـ Fluorescent and Cytohybridization ال
+
+565
+00:55:36,670 --> 00:55:45,910
+.. شوف سؤال 24 آه ما هو 24 خيار C لأ احنا الـ FISH
+
+566
+00:55:45,910 --> 00:55:55,170
+أنا طريقته اني انا بحط قطعة بتكون مثلا عشرة عشرين
+
+567
+00:55:55,170 --> 00:56:00,400
+ثلاثين اربعين ماعرفش كده يعني بالضبط مية بالميةمن
+
+568
+00:56:00,400 --> 00:56:07,300
+الـ «DNA Nucleotides» ماشي بحط ترتيب معين لحيث أنه
+
+569
+00:56:07,300 --> 00:56:12,460
+يعني شوف إذا اتخيلنا بطلب من الكل دائما هيك يفكر
+
+570
+00:56:12,460 --> 00:56:18,000
+فيها تتذكرها وكده لما نتكلم عن Single Nucleotide
+
+571
+00:56:18,000 --> 00:56:23,820
+إذا اتخيلنا البروتين قلنا مثال بالأول البروتين هو
+
+572
+00:56:23,820 --> 00:56:33,680
+عبارة عن قصيدة شعر ماشيلما أنا بدي أدور على اختلاف
+
+573
+00:56:33,680 --> 00:56:40,560
+حرف لازم أستخدم تقنية مختلفة عامة من اللي بدي أدور
+
+574
+00:56:40,560 --> 00:56:45,920
+إذا فيه اختلاف بيت معين أو Shutterbait يعني لما
+
+575
+00:56:45,920 --> 00:56:51,060
+أنا بستخدم الـFish والـMicrosatellite
+
+576
+00:56:51,060 --> 00:56:56,540
+Array Test ودولة الـKaryotyping بدور على الكرمزون
+
+577
+00:56:56,540 --> 00:57:02,510
+كله، ماشي؟وما باستحيل يفرجيني الـ Chromosome كله
+
+578
+00:57:02,510 --> 00:57:06,790
+الـ Single Nucleotide Polymorphism الـ Fluorescent
+
+579
+00:57:06,790 --> 00:57:11,230
+Encyto-Hybridization والـ Micro Satellite Array
+
+580
+00:57:11,230 --> 00:57:17,470
+بدك تحط الـ Segment of Interest لازم تكون كبير
+
+581
+00:57:17,470 --> 00:57:24,150
+شوية حتى إنه يقدر يكون فيه تفابق بين قطعتين مع بعض
+
+582
+00:57:24,570 --> 00:57:28,730
+يعني زي كأنك بتعمل Google search بتحف على شطر
+
+583
+00:57:28,730 --> 00:57:33,530
+القصيدة وبتشوف أني قصيدة قالوا فيها هالكلام مثلا
+
+584
+00:57:33,530 --> 00:57:39,770
+وقوفا بها صاحبي عليا مطيهم يقولوا للا تهلك أسن
+
+585
+00:57:39,770 --> 00:57:44,190
+وتجلد في هدولة في على الأقل شاعرين في الجهلية
+
+586
+00:57:44,190 --> 00:57:50,850
+قالوها فوقوفا بها صاحبي بقول هذه القطعة هي المميز
+
+587
+00:57:50,850 --> 00:57:57,330
+اللي أنا بدي إياها بجيببرنامج كمبيوتر زي جوجل في
+
+588
+00:57:57,330 --> 00:58:02,970
+كل قصاد الشعر في الدنيا وبزدت عليها وبدور مين حكى
+
+589
+00:58:02,970 --> 00:58:08,910
+مثل هذا البيت ماشي هيك هذولة fish و micro
+
+590
+00:58:08,910 --> 00:58:13,570
+-satellite array بس عشان أدقق إنه في حرف اختلف بين
+
+591
+00:58:13,570 --> 00:58:19,890
+حرف بين قصيدة وقصيدة تانية في مكان معين في شخص
+
+592
+00:58:19,890 --> 00:58:24,370
+معين أو كذا بدي أعمل polymerase chain reactionوالـ
+
+593
+00:58:24,370 --> 00:58:27,410
+Sequencing ما راح يديب ليها إلا الـ Sequencing
+
+594
+00:58:27,410 --> 00:58:33,210
+ماشي، يعني الـ Sequencing بتطلقلي براءة أحرف الـ
+
+595
+00:58:33,210 --> 00:58:39,370
+Nucleotides تبعات الـ ال DNA هذا عند هذا الإنسان
+
+596
+00:58:39,370 --> 00:58:45,290
+فلمّا نبدأ أدور على SNP Staining الـ Nucleotides
+
+597
+00:58:45,290 --> 00:58:49,910
+Polymorphism اللي اسمها SNP لازم أعمل Sequencing و
+
+598
+00:58:49,910 --> 00:58:50,370
+PCR
+
+599
+00:58:55,020 --> 00:59:01,240
+25 و26 من جدول straightforward الـ Abbreviations
+
+600
+00:59:01,240 --> 00:59:05,440
+لازم واحد يعرفها الـ Marker Chromosome اللي هو الـ
+
+601
+00:59:05,440 --> 00:59:10,460
+MAR يعني لما نستخدم الـ Fish والـ Microsatellite
+
+602
+00:59:10,460 --> 00:59:14,560
+الـ Math هو الـ Maternal Chromosome عكس الـ
+
+603
+00:59:14,560 --> 00:59:17,860
+Paternal Chromosome يعني الـ Chromosome نسخة من
+
+604
+00:59:17,860 --> 00:59:24,680
+الأم مش من الأب ماشي الـ Maternal فهذه واحدةلما
+
+605
+00:59:24,680 --> 00:59:30,760
+يحطوا Abbreviation يكون فيها بالأخير Positive فيه
+
+606
+00:59:30,760 --> 00:59:34,480
+Gain of function بعض الـ Diseases يا إما Loss أو
+
+607
+00:59:34,480 --> 00:59:38,460
+Gain of function وفيه Translocation الـT والـP
+
+608
+00:59:38,460 --> 00:59:41,900
+والـQ والـShort والـLong، أعرف هدولة Standard
+
+609
+00:59:41,900 --> 00:59:47,240
+Abbreviation يعني أنا بعتقد عشان الواحد بعدين في
+
+610
+00:59:47,240 --> 00:59:51,880
+حياته لما يقرأ النتائج
+
+611
+00:59:54,460 --> 00:59:59,380
+يكون متذكر هدول الـ abbreviation مهمات يعني أنا ب
+
+612
+00:59:59,380 --> 01:00:05,440
+.. كويس الواحد يتذكرها الـ Communist Mechanism of
+
+613
+01:00:05,440 --> 01:00:08,980
+Down Syndrome اللي هو associated with high
+
+614
+01:00:08,980 --> 01:00:13,300
+maternal age اللي هو non-disjunction in meiosis
+
+615
+01:00:13,300 --> 01:00:19,440
+هذه الإجابة الصحيحة في سؤال من دكتور بتقول في ممكن
+
+616
+01:00:19,440 --> 01:00:23,180
+توضيح أكثر لسؤال 21 اللي هو إيش؟
+
+617
+01:00:29,840 --> 01:00:35,700
+بس إنسان إنسان
+
+618
+01:00:35,700 --> 01:00:43,860
+عنده مثلًا Two chromosomes ناخد مثلًا الـ Blood
+
+619
+01:00:43,860 --> 01:00:52,980
+Group AB-Osystem ماشي الآن اللي عنده Group AB عنده
+
+620
+01:00:52,980 --> 01:00:57,580
+Two chromosomes which are أو عنده Two alleles
+
+621
+01:00:57,580 --> 01:01:03,000
+which are differentباعطونا Different Proteins اللي
+
+622
+01:01:03,000 --> 01:01:09,540
+هم الـ A و الـ B الإنسان العادي أو اللي بيصير في
+
+623
+01:01:09,540 --> 01:01:14,180
+الخلية العادية اللي كانت Red Blood Cell راح تصير
+
+624
+01:01:14,180 --> 01:01:19,660
+Red Blood Cell في الـ Development تبع الـ Red
+
+625
+01:01:19,660 --> 01:01:24,900
+Blood Cell اللي عنده AB على كل خلية بظهر الـ A و
+
+626
+01:01:24,900 --> 01:01:31,340
+بظهر الـ B بنفس الدرجة فهدولةبتكون equal
+
+627
+01:01:31,340 --> 01:01:38,080
+expression of the two alleles هاي ظاهرة بتحدث في
+
+628
+01:01:38,080 --> 01:01:42,560
+بعض الخلايا، في بعض الأليل وبالنسبة للي بيسموها
+
+629
+01:01:42,560 --> 01:01:47,260
+Allelic Expression Level ماشي، فيها slide شرحناها
+
+630
+01:01:47,260 --> 01:01:55,720
+من قبل فالآن، هاي ظاهرة بتحدث بس كمان بتحدث إنه
+
+631
+01:01:55,720 --> 01:01:59,940
+بيكون إنهيعني هنا بدنا نعتبر الـ Expression في هذه
+
+632
+01:01:59,940 --> 01:02:05,680
+الخلية لهذه الـ Two Alleles fifty-fifty خمسين
+
+633
+01:02:05,680 --> 01:02:10,560
+خمسين، قط بعض أحياناً في بعض الخلايا التانية أو
+
+634
+01:02:10,560 --> 01:02:15,260
+البروتينات التانية أو الأوضاع التانية بنلاقي الـ
+
+635
+01:02:15,260 --> 01:02:21,320
+Expression مية صفر يعني هو عنده Two Alleles ماشي
+
+636
+01:02:21,320 --> 01:02:29,620
+في هذه الخلية الـA مية والـB صفرخلية ثانية الـ B
+
+637
+01:02:29,620 --> 01:02:35,060
+صفر الـ B100 والـ A صفر ماشي ففي اللي هنا بدنا
+
+638
+01:02:35,060 --> 01:02:39,060
+نسميه اسمه الـ Allelic Exclusion يعني في كل خلية
+
+639
+01:02:39,060 --> 01:02:46,780
+القليل اللي بيشتغل بمنع القليل التاني يتكوّن واضح؟
+
+640
+01:02:46,780 --> 01:02:53,260
+فهي بنسميه اللي هو Allelic Exclusion يعني ما بيصير
+
+641
+01:02:53,260 --> 01:02:58,860
+نفس الخلية تتطلعنوعين مختلفين من الـA والـB بتطلع
+
+642
+01:02:58,860 --> 01:03:04,440
+يا A يا B هاي أحياناً بحده وأحياناً fifty-fifty في
+
+643
+01:03:04,440 --> 01:03:08,880
+نفس الخلية برضه بحده ومرات Unbalanced Expression
+
+644
+01:03:08,880 --> 01:03:15,100
+برضه بحده ماشي الـLionization اللي هو for X
+
+645
+01:03:15,100 --> 01:03:20,680
+-Chromosome deactivation هو Allelic Exclusion يعني
+
+646
+01:03:20,680 --> 01:03:26,150
+في كل خليةيا هذا الـ X-Chromosome شغال من الأبو
+
+647
+01:03:26,150 --> 01:03:29,910
+الـ X-Chromosome تبع الأب يا إما الـ X-Chromosome
+
+648
+01:03:29,910 --> 01:03:34,150
+تبع الأم يكون شغال في الخلية الواحدة بس في جسم
+
+649
+01:03:34,150 --> 01:03:43,330
+الإنسان يعني قد يكون نص بالنص، ربع بالتلترباع،
+
+650
+01:03:43,330 --> 01:03:49,650
+أنايت، يعني بس النوعين موجودة فاهمي علي؟ فأحيانًا
+
+651
+01:03:49,650 --> 01:03:55,650
+الـ يعني هي الـ Early Embryogenesisتضطر الخلايا
+
+652
+01:03:55,650 --> 01:04:02,390
+إنه تقرر أنه واحد منهم بدي يشتغل وفي كل نواتج هذه
+
+653
+01:04:02,390 --> 01:04:07,390
+الخلايا إذا قررت إن هذا الـChromosome أو هذا
+
+654
+01:04:07,390 --> 01:04:13,190
+الأليل اللي بدي يشتغل هو بيظلها عليه، بتجلبش على
+
+655
+01:04:13,190 --> 01:04:18,430
+النوع التاني إن شاء الله إنه واضح، إذا في تحديد
+
+656
+01:04:18,430 --> 01:04:21,890
+أكبر لإيش اللي مش واضح، تحكيليه
+
+657
+01:04:30,120 --> 01:04:35,440
+بالنسبة لـ Chromosomal Anomaly Not Compatible With
+
+658
+01:04:35,440 --> 01:04:41,180
+Live Birth الـ Triploid و التترابلويد هذه مش
+
+659
+01:04:41,180 --> 01:04:46,200
+compatible، ما في إنا إيه يعني الـ Triploid و
+
+660
+01:04:46,200 --> 01:04:52,860
+التترابلويد في النباتات شائعة جدا يعني إحنا في
+
+661
+01:04:52,860 --> 01:05:00,730
+خلايانا كلها 2MالـEgg والـSperm 1N في الـCell
+
+662
+01:05:00,730 --> 01:05:05,830
+Division فليه لما تنقسم أو في الـCancer ممكن نلاقي
+
+663
+01:05:05,830 --> 01:05:16,090
+4N، 5N، 6N يكون أو 6N يعني تطلع تـTriploid، ناشي؟
+
+664
+01:05:16,090 --> 01:05:22,870
+لما نقول Ploid لكل الجينوم، لكل الكرمزومات، ناشي؟
+
+665
+01:05:22,870 --> 01:05:30,830
+فهذه لما تتـ .. يعني يصيربشكل ما مثلا بدل ما يعني
+
+666
+01:05:30,830 --> 01:05:38,070
+الخلية تيجي تنقسم في حالة الـSperm أو الـEgg ومثلا
+
+667
+01:05:38,070 --> 01:05:42,930
+الـCentromere يفشل الـCentrosome يفشل وكل الـTwo
+
+668
+01:05:42,930 --> 01:05:48,310
+copies يروح في جهة واحدة فبالتالي الـSperm أو
+
+669
+01:05:48,310 --> 01:05:52,190
+الـEgg راح يكون فيه Two N مش One N فلما تصير
+
+670
+01:05:52,190 --> 01:05:59,460
+التلقيح بيصير Three N أوممكن يصير 4M فهذه لما تحدث
+
+671
+01:05:59,460 --> 01:06:06,640
+هذا فاشل نهائيًا لا يمكن يكمل البقية تحدث ممكن
+
+672
+01:06:06,640 --> 01:06:12,400
+يوصل الـ Down Syndrome تحدث الـ Super Female XXX
+
+673
+01:06:12,400 --> 01:06:17,120
+تحدث الـ Balance Rearrangement في الأب نفسه أو
+
+674
+01:06:17,120 --> 01:06:23,150
+الأمبكون إذا حدثت مظبوط والـ XYY برضه بتحدث هدولة
+
+675
+01:06:23,150 --> 01:06:31,290
+مش incompatible with lifestyle ناشي؟ الـ Most
+
+676
+01:06:31,290 --> 01:06:34,210
+Important Risk Factor for the occurrence of
+
+677
+01:06:34,210 --> 01:06:37,790
+Trisomy 21 اللي هو الـ Increasing Maternal Age الـ
+
+678
+01:06:37,790 --> 01:06:41,450
+Smoking، الـ Mumps، الـ Exposure، الـ Radiation
+
+679
+01:06:41,450 --> 01:06:46,030
+جرمن نيزل، هدولة كلهم بيعملوا مشاكل تانية بس مش
+
+680
+01:06:46,030 --> 01:06:51,810
+الـ Down SyndromeالـExample of chromosomal segment
+
+681
+01:06:51,810 --> 01:06:59,670
+اللي هي الـshort arm الـP11 short arm of the
+
+682
+01:06:59,670 --> 01:07:06,110
+chromosome 22 أو 21 اللي هو Diehard Syndrome
+
+683
+01:07:06,110 --> 01:07:12,750
+الأكندروبلازيا Single mutation of chromosomal
+
+684
+01:07:12,750 --> 01:07:18,450
+dominant الـBronchial asthma بوليجينيةالهيموفيليا
+
+685
+01:07:18,450 --> 01:07:25,670
+A وB عبارة عن Single Gene والـ Clam Filter مش
+
+686
+01:07:25,670 --> 01:07:30,650
+كرومزوم، سيجمند، كرومزوم كامل، بيبقى Problem فده
+
+687
+01:07:30,650 --> 01:07:40,210
+الـ George's Syndrome الصحيح فالـ 31 What's
+
+688
+01:07:40,210 --> 01:07:44,630
+the main driving force for normal for female sex
+
+689
+01:07:45,150 --> 01:07:48,950
+الـ Development هي الـ Default وعدم وجود الـ Y
+
+690
+01:07:48,950 --> 01:07:56,410
+-Chromosome اللي بيخلّي الإنسان يصير Female إنه
+
+691
+01:07:56,410 --> 01:08:02,370
+مافيش Y-Chromosome أو مش شغال و
+
+692
+01:08:02,370 --> 01:08:09,440
+الـ Inactive X-Chromosome اللي هو الـ Bar Bodyالـ
+
+693
+01:08:09,440 --> 01:08:14,260
+Communist Sex Chromosome الـ «أنوميلي» الميل في
+
+694
+01:08:14,260 --> 01:08:22,680
+الـ «تينوتيب» الـ «Kleinfilter» اللي هو XYY لما
+
+695
+01:08:22,680 --> 01:08:26,560
+يكون في عندي Double Lines بالنسبة للـ Pedigree
+
+696
+01:08:26,560 --> 01:08:32,920
+اللي هو إن وجود Consanguinity لما نحط Double Lines
+
+697
+01:08:32,920 --> 01:08:38,690
+ماشي، الـ Horizontal Linesالـ Probant بيحطوه هيك
+
+698
+01:08:38,690 --> 01:08:45,290
+سهل الـ twins identical و not identical دو ال male
+
+699
+01:08:45,290 --> 01:08:51,430
+و female سيمبل الدائرة و المربع و كده و هيك main
+
+700
+01:08:51,430 --> 01:08:55,250
+second degree relative ال parents و ال brothers و
+
+701
+01:08:55,250 --> 01:08:59,810
+ال children ا first degree ال parents و ال
+
+702
+01:08:59,810 --> 01:09:05,270
+brothers و ال children ال spouse الأصل بعيد الأصل
+
+703
+01:09:06,420 --> 01:09:13,120
+الـ Second degree relative، الـ Grandparents الآن،
+
+704
+01:09:13,120 --> 01:09:18,920
+الـ Disease transmitted on maternal line only الـ
+
+705
+01:09:18,920 --> 01:09:22,060
+Females transmit the disease to their children،
+
+706
+01:09:22,060 --> 01:09:25,700
+both males and females and affected males do not
+
+707
+01:09:25,700 --> 01:09:27,900
+transmit the disease، الـ Definition تبع
+
+708
+01:09:27,900 --> 01:09:35,770
+الميتيكودريالية، حكينا السبب من قبلهذا سؤال اللي
+
+709
+01:09:35,770 --> 01:09:41,270
+هو Single gene disease that affects male المفروض
+
+710
+01:09:41,270 --> 01:09:45,930
+كان حطيت كومة والـ females are normal carriers
+
+711
+01:09:45,930 --> 01:09:50,690
+اللي هو X-linked recesses الناس قالوها جملة واحدة
+
+712
+01:09:50,690 --> 01:09:56,270
+affects males and females لأ طيب
+
+713
+01:10:00,200 --> 01:10:04,320
+بالنسبة لسؤال 38 regarding the frequencies of
+
+714
+01:10:04,320 --> 01:10:07,120
+different types of genetic disorders in different
+
+715
+01:10:07,120 --> 01:10:16,820
+stages of life، All statements، نتذكر إنه الأول،
+
+716
+01:10:16,820 --> 01:10:23,480
+نسبة أو احتمالية حدوث سواء single gene أو
+
+717
+01:10:23,480 --> 01:10:30,440
+chromosomal disorders much higherواللي بيظل عند
+
+718
+01:10:30,440 --> 01:10:35,360
+الإنسان لما يكون كبير بالعمر أو كان يكبر بالعمر أو
+
+719
+01:10:35,360 --> 01:10:37,880
+الـ General population بتكون Multifactorial
+
+720
+01:10:37,880 --> 01:10:42,460
+Diseases فالـ Frequencies of single gene disorders
+
+721
+01:10:42,460 --> 01:10:47,760
+are rarer، less frequent than genome اللي هو
+
+722
+01:10:47,760 --> 01:10:52,300
+Multifactorial or Chromosomal disorders and all
+
+723
+01:10:52,300 --> 01:10:56,120
+stages هاي غلط
+
+724
+01:10:57,720 --> 01:11:04,640
+Multifactorial في الأول صحيح هما لسه الـMost
+
+725
+01:11:04,640 --> 01:11:09,460
+Frequent بس يعني إذا بتشوف الصورة مثلا عشرة Single
+
+726
+01:11:09,460 --> 01:11:14,680
+Gene وخمسين Multifactorial بعدها بيصير الـSingle
+
+727
+01:11:14,680 --> 01:11:19,880
+Gene مثلا عشرين على الـGeneral Population
+
+728
+01:11:19,880 --> 01:11:23,240
+والـMultifactorial 600 بصورة ده بيصير عددهم كبير
+
+729
+01:11:23,240 --> 01:11:27,770
+كتيرالـ Single Gene and Genome and Chromosome الـ
+
+730
+01:11:27,770 --> 01:11:31,070
+Single Gene and Genome and Chromosome الـ
+
+731
+01:11:31,070 --> 01:11:35,090
+disorders are more frequent at birth صحيح؟ إذا في
+
+732
+01:11:35,090 --> 01:11:40,370
+Single Gene وChromosomal disorders at birth الـ
+
+733
+01:11:40,370 --> 01:11:43,070
+Multifactorial disorders increasing prevalence و
+
+734
+01:11:43,070 --> 01:11:46,310
+decreasing age in general population صحيح؟ وفي
+
+735
+01:11:46,310 --> 01:11:50,630
+حوالي 600 Multifactorial disease صحيح؟
+
+736
+01:11:54,060 --> 01:11:58,600
+الـ Normal Distribution تعريفه إنه الـ «مين» والـ
+
+737
+01:11:58,600 --> 01:12:02,820
+«مود» والـ «ميديان» «المين» متوسط الحسابي «المود»
+
+738
+01:12:02,820 --> 01:12:08,740
+اللي هو أكتر بقراءة طالعة «الميديان» هو اللي
+
+739
+01:12:08,740 --> 01:12:13,340
+بنرتبهم من الأول لأخر بنحط المنتصف المنصي الـ
+
+740
+01:12:13,340 --> 01:12:18,000
+«ميديان» فدولة كلهم جات بعض فهذا الصحيح الـ «مين»
+
+741
+01:12:18,000 --> 01:12:21,820
+plus minus one standard deviation 67% من
+
+742
+01:12:21,820 --> 01:12:25,930
+الpopulation صحيحاللي تبدو مثلًا كـ Bell-shaped
+
+743
+01:12:25,930 --> 01:12:30,090
+with two tails، صحيح الـmean plus two standard
+
+744
+01:12:30,090 --> 01:12:34,730
+deviations 95% من المجتمع، صحيح الـmany traits and
+
+745
+01:12:34,730 --> 01:12:38,610
+distribution follow
+
+746
+01:12:38,610 --> 01:12:41,550
+this distribution، الـnormal distribution و it's
+
+747
+01:12:41,550 --> 01:12:47,490
+important for research، صحيحة جدًا أقوى familial
+
+748
+01:12:47,490 --> 01:12:52,190
+aggregation، اللي هي الـrisk ratio، اللي هي الرمزة
+
+749
+01:12:52,190 --> 01:12:56,780
+هذهLambda S في هذه الشكلة أيضًا اللي هو الأولى للـ
+
+750
+01:12:56,780 --> 01:13:01,980
+Autism 150 يعني شفت البقية كلهم فيهن بس هي أقوى
+
+751
+01:13:01,980 --> 01:13:06,840
+واحد الدرجات أكبر بكتير يعني
+
+752
+01:13:06,840 --> 01:13:14,960
+الـ Recall مباشر يعني إذا بنلاقي Familial
+
+753
+01:13:14,960 --> 01:13:21,750
+Aggregation of Diseaseبعد مصادر الجنية، أي مصادر
+
+754
+01:13:21,750 --> 01:13:25,950
+قد تشرح الفميلة الـ Aggregation بديوا يكونوا
+
+755
+01:13:25,950 --> 01:13:31,190
+shared environmental exposure يعني والله المرض هذا
+
+756
+01:13:31,190 --> 01:13:36,730
+بيسببوا تسمم بالرصاص مثلا، اللي ما هو إذا طفل
+
+757
+01:13:36,730 --> 01:13:40,870
+اتسمم بالرصاص في هذه العيلة ممكن إخوانه القواكب
+
+758
+01:13:40,870 --> 01:13:44,350
+اللي عايشين عندهم كانوا بتعرضوا لنفس الرصاص لأنهم
+
+759
+01:13:44,350 --> 01:13:48,670
+بيعيشوا بنفس البيئة ف sharedالـ Environmental
+
+760
+01:13:48,670 --> 01:13:52,250
+Exposure هو الـ Other Explanation of the Familial
+
+761
+01:13:52,250 --> 01:13:56,610
+Aggregation of Disease الـ Gene Polymorphism
+
+762
+01:13:56,610 --> 01:14:02,630
+وDevelopmental Of Mutation وSame Family Name يعني
+
+763
+01:14:02,630 --> 01:14:07,490
+كلها مش هي المسببة أو التفسير الآخر للـ Familial
+
+764
+01:14:07,490 --> 01:14:11,010
+Aggregation اللي هي Shared Environmental Exposure
+
+765
+01:14:12,620 --> 01:14:17,600
+السؤال، هذا الأسئلة اللي بعدين هي من المراجع
+
+766
+01:14:17,600 --> 01:14:27,980
+تبعتها فيها يعني قصص أو stories وكذا وبنجيب
+
+767
+01:14:27,980 --> 01:14:34,600
+يعني أظن فيها يعني points مش غلط الواحد يتطلع عليه
+
+768
+01:14:37,480 --> 01:14:44,840
+فيه researcher اللي الواحد بيقراها بده يدرس الـ
+
+769
+01:14:44,840 --> 01:14:53,140
+Fast Ligand Interaction وفي حالة في عائلة بيشوف إن
+
+770
+01:14:53,140 --> 01:14:59,680
+فيها مشكلة فيها أيوة هدين فيه
+
+771
+01:14:59,680 --> 01:15:02,800
+أسئلة كأنه في حد بده
+
+772
+01:15:07,970 --> 01:15:16,090
+الآن الـ… الـ بالنسبة لهذا السؤال فيه بيحكي عن إن
+
+773
+01:15:16,090 --> 01:15:20,010
+الـ Fas-Fas-Ligand interaction مهم عشان الـ
+
+774
+01:15:20,010 --> 01:15:28,070
+control لـ الـ Apoptosis وفي أشياء كتيرة فالـ الآن
+
+775
+01:15:28,070 --> 01:15:34,450
+لقى في هذه الحالة إن الـ Fas-Protein هم كلهم الـ
+
+776
+01:15:34,450 --> 01:15:38,320
+Fas-Fas-Ligand هم عبارة عن self-service proteinفهو
+
+777
+01:15:38,320 --> 01:15:42,960
+بيشرح شو هي وبيحكي معلومات عنها فلاحظ عند العائلة
+
+778
+01:15:42,960 --> 01:15:48,600
+هذه إن الـ Soluble Fas Protein اللي لقاهم Shorter
+
+779
+01:15:48,600 --> 01:15:58,720
+وLacked Transmembrane Domain ماشي؟ لما
+
+780
+01:15:58,720 --> 01:16:03,200
+شاف الـ DNA Analysis of these cells revealed no
+
+781
+01:16:03,200 --> 01:16:10,100
+Fas gene mutationيعني نفس الجين موجود بالثنتين بس
+
+782
+01:16:10,100 --> 01:16:15,260
+الأصل يكون البروتين عبارة عن Trans-Membrane Domain
+
+783
+01:16:15,260 --> 01:16:18,760
+وIntra-Cytoplasmic Membrane والـ Extra-Cytoplasmic
+
+784
+01:16:18,760 --> 01:16:22,480
+يعني Extra-Cytoplasmic والـ Trans-Membrane والـ
+
+785
+01:16:22,480 --> 01:16:27,820
+Intra-Cytoplasmic تاني هيك الأصل فالـ DNA متشابه
+
+786
+01:16:27,820 --> 01:16:32,060
+فالـ explanation
+
+787
+01:16:33,640 --> 01:16:37,040
+اللي هو الـ Alternative Splicing الـ Alternative
+
+788
+01:16:37,040 --> 01:16:43,040
+Splicing اللي هو بيقطع الأشياء الـ Defective
+
+789
+01:16:43,040 --> 01:16:47,320
+polyadenylation و DNA methylation دولة تبعات الـ
+
+790
+01:16:47,320 --> 01:16:52,960
+polygenic أو الـ Epigenetic Control الـ Protein
+
+791
+01:16:52,960 --> 01:16:58,180
+Lubrication والأشياء دي كمال هيتخلط مش هيك من
+
+792
+01:16:58,180 --> 01:17:05,390
+المرجع وإذا كان واحد قارى وعرف يجيبهاأحسن، نعم يا
+
+793
+01:17:05,390 --> 01:17:08,750
+هديل هذا
+
+794
+01:17:08,750 --> 01:17:12,090
+السؤال يعني إحنا لما أنت شرحتينا إياه ماقولتلى ما
+
+795
+01:17:12,090 --> 01:17:14,530
+تركزوش كتير على ال alternatives splicing و الشغلات
+
+796
+01:17:14,530 --> 01:17:17,870
+هذه لإنها مش كتير بتهمك هو صح كلامك إنه السؤال من
+
+797
+01:17:17,870 --> 01:17:23,430
+المرجع بس إن إحنا عندنا الـ أسا اسمع علي، يا هديل،
+
+798
+01:17:23,430 --> 01:17:26,650
+ما بيجيبوني أسألهم اسمع علي يا هديل، غير لما
+
+799
+01:17:26,650 --> 01:17:29,350
+يكونوا إن أنا بدرسها من الكتاب، ماركزتش عليها كتير
+
+800
+01:17:29,350 --> 01:17:37,110
+أفهمي علي، لا لا، افهمي علييعني هي الفكرة الفكرة
+
+801
+01:17:37,110 --> 01:17:42,730
+أنا لازم في الامتحانات أحط بعض الأسئلة الأصعب اللي
+
+802
+01:17:42,730 --> 01:17:49,370
+ما مش كل الناس يجاوبوها ماشي و بعدين يعني أنا ال
+
+803
+01:17:49,370 --> 01:17:54,770
+trick في السؤال هذا النقطة اللي بدي تخبية منه هو
+
+804
+01:17:54,770 --> 01:18:00,190
+بصفلك يعني للأسف السؤال طويل يعني ماشي هو يمكن
+
+805
+01:18:00,190 --> 01:18:04,840
+أصعب من غيرهفالواحد يكون بعض الأسئلة الصعبة مش غلط
+
+806
+01:18:04,840 --> 01:18:14,000
+بالنسبة للأن زي هيك البروتين العادي تفكر لانك يا
+
+807
+01:18:14,000 --> 01:18:19,940
+دكتور بيكون طويل فهمتي؟ والـ DNA يعني هذا البروتين
+
+808
+01:18:19,940 --> 01:18:25,180
+طلق أقصى والـ DNA the same يعني لمّا نقدر نفعث نفس
+
+809
+01:18:25,180 --> 01:18:29,900
+الـ gene تبع الـ DNA على مستوى الـ DNA مالكاش فيه
+
+810
+01:18:29,900 --> 01:18:36,100
+مشكلةففي الحالة هذه المشكلة
+
+811
+01:18:36,100 --> 01:18:39,300
+أو الملاحظة راح تكون إنه في عندي الـAlternative
+
+812
+01:18:39,300 --> 01:18:42,480
+slicing pool most likely يعني by guessing you
+
+813
+01:18:42,480 --> 01:18:49,820
+might have got it أما هو شويه سؤال أصعب و .. أهأنا
+
+814
+01:18:49,820 --> 01:18:52,480
+يا دكتور، لعند إن الـDNA مافيش عليها مشاكل معناها
+
+815
+01:18:52,480 --> 01:18:54,580
+إنه الأشي في الـepigenetics mechanism عشانك أنا
+
+816
+01:18:54,580 --> 01:18:57,760
+يوم حطيتها DNA methylation مادكتش كتير على
+
+817
+01:18:57,760 --> 01:18:59,580
+الـAlternatives of splicing لأن أحنا أصلا مش
+
+818
+01:18:59,580 --> 01:19:00,340
+مابنعرفش على
+
+819
+01:19:00,340 --> 01:19:19,120
+الـ……………………………………………………………………………………………………………………………………………………………………………………
+
+820
+01:19:19,390 --> 01:19:23,490
+ماشي، الـ Epigenetic… «كامل إنهيبش للإنزين ممكن»
+
+821
+01:19:23,490 --> 01:19:28,930
+نعم، لأ لأ، الـ «ممكن تعمل إنهيبش للبروتين» يعني
+
+822
+01:19:28,930 --> 01:19:33,750
+أيه؟ «ممكن تعمل أيه، دكتور؟» الـ Epigenetic
+
+823
+01:19:33,750 --> 01:19:40,570
+Control هو بيقرر هل البروتين هذا هيطلع ولا لأ بس
+
+824
+01:19:40,570 --> 01:19:44,750
+ما بيغير بالبروتين يعني هي بيغير كمية اللي طلع منه
+
+825
+01:19:44,750 --> 01:19:49,200
+بس ما بيغير في شكل البروتين نفسهفالقصص اللي
+
+826
+01:19:49,200 --> 01:19:53,980
+بيحكيلك إياها في الـ Fast Protein اللي طلعت هنا هي
+
+827
+01:19:53,980 --> 01:19:58,220
+على مسكواة إحنا حكينا اللي بدل واحد يتذكر إنه أول
+
+828
+01:19:58,220 --> 01:20:02,400
+شيء الـ DNA بيصير له Messenger RNA أو للـ RNA الـ
+
+829
+01:20:02,400 --> 01:20:06,820
+Primary وفيه Introns و Extrons وبيصير قطة أو لسق
+
+830
+01:20:06,820 --> 01:20:09,440
+وبالذات لما نقوله Trans-Membrane وIntra
+
+831
+01:20:09,440 --> 01:20:13,180
+-Cytoplasmic Domain هذه بالـ Alternative Splicing
+
+832
+01:20:13,810 --> 01:20:18,510
+يعني حتى أنا بالنسبة لموضوع زي الـSecreted وCell
+
+833
+01:20:18,510 --> 01:20:23,850
+Surface Form of Immunoglobulins بالمنعها، أمر على
+
+834
+01:20:23,850 --> 01:20:27,310
+مستوى الـRNA بالـAlternative Splicing، يعني مافيه
+
+835
+01:20:27,310 --> 01:20:30,590
+إشي بالمرحلة دي، على كل ما –يعني يا دكتور، حكيت
+
+836
+01:20:30,590 --> 01:20:34,690
+نفسي أول ما جيبت نفسي ريتها وانت بتشرحها –إيش هو؟
+
+837
+01:20:34,690 --> 01:20:39,510
+أسا ماجيبتهاش وماجيبتها الله يرضى عليكي، أنت أسا
+
+838
+01:20:39,510 --> 01:20:43,230
+المهم جيبيها ولمّا تيجي تدرس الـUSMLE، جيبيها صح
+
+839
+01:20:43,550 --> 01:20:49,610
+فبنجيلك زي هيك إنه فيه مشكلة إنه أكتر من Form اللي
+
+840
+01:20:49,610 --> 01:20:53,430
+صارت يعني أو اللي هي راح نجي بعدين أنا لأن ما كنت
+
+841
+01:20:53,430 --> 01:20:59,490
+شرحتها سبب ثاني إذا بيحكوا عنه اللي هو الـ Stop
+
+842
+01:20:59,490 --> 01:21:04,430
+Codon يعني سبب ثاني يعني بدل ما هي البروتين طويل
+
+843
+01:21:04,430 --> 01:21:08,650
+كتير وفيه أكتر من قطعة إذا فيه Stop Codon ممكن
+
+844
+01:21:08,650 --> 01:21:12,070
+يكون تفسير آخر يعني لو حطوا Stop Codon يمكن أنت
+
+845
+01:21:12,070 --> 01:21:19,590
+كنت راح أقبلهعلى كل المعرفة هديل إذا ما عليك ترجع
+
+846
+01:21:19,590 --> 01:21:22,950
+إلى المرجع اللي أخدت السؤال منه هيحطته فيه موجود
+
+847
+01:21:22,950 --> 01:21:27,410
+مفروض عندكم وإقرأ ال explanation ليش باقية الأشياء
+
+848
+01:21:27,410 --> 01:21:32,490
+مابتدفعش فاهمي عليك؟ قرأته قرأته والله قرأته بس
+
+849
+01:21:32,490 --> 01:21:35,190
+إنه أنا قصدي إنه هذا يعني هذا إشي إحنا ماأخدنهش
+
+850
+01:21:35,190 --> 01:21:37,990
+يعني ماكنش في نطاق درستنا لما درستنا للامتحان فإنه
+
+851
+01:21:37,990 --> 01:21:42,260
+يعني يعني السؤال يعني المفروض إن مثلالأ لما .. لأ
+
+852
+01:21:42,260 --> 01:21:47,680
+لأ لأ لأ لأ اسمع عليك اسمع عليك لأ لأ لأ ما شو أحط
+
+853
+01:21:47,680 --> 01:21:53,200
+شو ما أحط أنا كل ما تطلعوا أحسن اسمع عليك كل ما
+
+854
+01:21:53,200 --> 01:21:59,860
+تطلعوا أحسن تكونوا أحسن ماشي و أنا بظن يعني أنا
+
+855
+01:21:59,860 --> 01:22:03,400
+اللي عجبني على الأقل حتى بالإجابة الأولى كنت راحلة
+
+856
+01:22:03,400 --> 01:22:07,000
+لما أقرأ الإجابات و أقرأ السؤالالفرق في إنه
+
+857
+01:22:07,000 --> 01:22:11,660
+الاختلاف الـ methylation مش راح يوقف الـ البروتين
+
+858
+01:22:11,660 --> 01:22:16,200
+ولا الـ polyadenylation ولا الـ RNA يعني ممكن
+
+859
+01:22:16,200 --> 01:22:19,900
+الشغل على الـ messenger RNA كنت راح أشوف فيه لو
+
+860
+01:22:19,900 --> 01:22:22,960
+ماكنتش عارف أنها أيه يعني بس قريت الـ stem اللي
+
+861
+01:22:22,960 --> 01:22:28,820
+فوق على كل حال يعني السؤال يمكن خلافك على إنه هل
+
+862
+01:22:28,820 --> 01:22:35,490
+هذا مناسب نجيبه ولا مانجيبوشبقول ممكن أنه أنا جيت
+
+863
+01:22:35,490 --> 01:22:39,870
+إشي من المرجع ممكن أنتم طلعتوا عليها وما طلعتوش
+
+864
+01:22:39,870 --> 01:22:44,070
+عليها وما .. ما بتلزموني أنه لازم تجيب سؤال اللي
+
+865
+01:22:44,070 --> 01:22:47,950
+أنا كنت شرحته ولا ما شرحته إذا عايشي في المرجع،
+
+866
+01:22:47,950 --> 01:22:51,830
+إذا عايشي في المرجع أو في اللي .. اللي أنا شرحته
+
+867
+01:22:51,830 --> 01:22:56,610
+بالكلام فهو كلام مقبول، على كل درجة ما هو يا
+
+868
+01:22:56,610 --> 01:23:00,010
+دكتور، بس إحنا مارجعنا الكتاب، مارجعنا كل كتاب
+
+869
+01:23:00,010 --> 01:23:03,240
+كتاببس احنا مارجعنا الكتاب و كلامك في المادة، صح
+
+870
+01:23:03,240 --> 01:23:08,140
+ولا لأ؟ هذا كان كلام صحيح، بس اسمع عليه، اسمع
+
+871
+01:23:08,140 --> 01:23:13,360
+عليه، الأشياء، الأشياء اللي فيها MCQ زي هيك سهلة
+
+872
+01:23:13,780 --> 01:23:18,820
+أنا إن شاء الله لما نخلص ال .. أنا جد مادخلتش
+
+873
+01:23:18,820 --> 01:23:22,200
+المراجع التاني سبعة ال «unsecured» أنا ماكن قصدي
+
+874
+01:23:22,200 --> 01:23:25,680
+بس هذا الكتاب اللي أنتم بدكم ترجعوا إليه شاهد
+
+875
+01:23:25,680 --> 01:23:29,040
+عليه؟ و من دكتور أحمد تفاهمي هو دكتور كتاب
+
+876
+01:23:29,040 --> 01:23:31,880
+«تومسون» يعني كتاب «تومسون» كتير كتير كبير و كتير
+
+877
+01:23:31,880 --> 01:23:33,400
+متعين في الدراسة دكتور حديث، دكتور حديث، دكتور
+
+878
+01:23:33,400 --> 01:23:34,340
+حديث، دكتور حديث، دكتور حديث، دكتور حديث، دكتور
+
+879
+01:23:34,340 --> 01:23:38,680
+حديث، دكتور حديث، دكتور حديث، دكتور حديث، دكتور
+
+880
+01:23:38,680 --> 01:23:46,010
+حديث، دكتور حديفيه بروتين أكتر من segment واتوقف
+
+881
+01:23:46,010 --> 01:23:51,490
+عند segment معينة المشكلة هي ممكن في stop codon
+
+882
+01:23:51,490 --> 01:23:56,830
+بالأخير يعطيني shorter messenger RNA أو
+
+883
+01:23:56,830 --> 01:24:02,550
+بالـAlternative splicing، ماجبش شي على تكون هيك
+
+884
+01:24:02,550 --> 01:24:07,390
+أنا الساعة عشر عندى محاضرة تانية وعندى شغل تانيأه
+
+885
+01:24:07,390 --> 01:24:12,350
+لك الله يا دكتور، اللي إحنا يعني بدناش نجف على
+
+886
+01:24:12,350 --> 01:24:18,230
+يعني نقطة معينة مثلا، الدكتور لما حكى السؤال بحد
+
+887
+01:24:18,230 --> 01:24:21,210
+ذاته، بيتكلم مش عن انفاص بروتين ولا بيتكلم على
+
+888
+01:24:21,210 --> 01:24:26,390
+القضايا هذه، بيتكلم عن صناعة البروتينأعتقد النقطة
+
+889
+01:24:26,390 --> 01:24:30,070
+دي اتحدث عنها الدكتور و ربما ذكرها كتاب «تومسون»
+
+890
+01:24:30,070 --> 01:24:33,830
+فالفكرة أنه حتى الامتحان نفسه احنا بنتعلم كمان منه
+
+891
+01:24:33,830 --> 01:24:37,250
+و الأسئلة اللي تيجي في الامتحان احنا بناخد منها
+
+892
+01:24:37,250 --> 01:24:41,350
+معلومات فمش هنجف عند كل سؤال نقول هذا لأجان و هذا
+
+893
+01:24:41,350 --> 01:24:45,430
+مجاناش، مظبوط إزايك و يعني المادة بتمشيش صحيح
+
+894
+01:24:45,430 --> 01:24:50,190
+خليني بالمية الكلام اللي قصديها، الآن الأسئلة
+
+895
+01:24:50,190 --> 01:24:55,420
+الباقية كلها من مراجع من براالآن healthy couple
+
+896
+01:24:55,420 --> 01:25:06,440
+وعندهم autosomal recessive disease ماشي وأجت ال ال
+
+897
+01:25:06,440 --> 01:25:10,180
+next child what is the probability to be affected
+
+898
+01:25:10,180 --> 01:25:18,120
+الربع ماشي standard لأنههم من متقاربين احتمال مش
+
+899
+01:25:18,120 --> 01:25:21,600
+Consanguinity بس أثنانهم من Eastern Europe في
+
+900
+01:25:21,600 --> 01:25:27,780
+أمريكا وFirst Diseased Child في الغالب بمعنهم Too
+
+901
+01:25:27,780 --> 01:25:33,340
+Healthy معناتها هدولة Ethosomal Recessive وبالتالي
+
+902
+01:25:33,340 --> 01:25:41,620
+كل Birth الاحتمالية ربع السؤال اللي بعده فيه إشي
+
+903
+01:25:41,620 --> 01:25:47,190
+يعني الاللي هو بيسموه Transcription Regulators
+
+904
+01:25:47,190 --> 01:25:53,730
+برضه هذا يعني إنكن أنا ما عرضتوش كتير بس شفت إنه
+
+905
+01:25:53,730 --> 01:25:58,970
+مهم من ناحية الـ يعني اقرأوا المرجعين هدولة يعني
+
+906
+01:25:58,970 --> 01:26:06,570
+على قل يعني بتكون فيها Points اللي هو
+
+907
+01:26:06,570 --> 01:26:12,260
+Transcription RegulatorsH1 هستون برضه ما شرحتهاش
+
+908
+01:26:12,260 --> 01:26:19,440
+أبداً بس برضه يعني ترتيبها والـ يعني بداية الـ
+
+909
+01:26:19,440 --> 01:26:29,640
+guessing شكل شو اسمه مفيد 26 year old woman فيه
+
+910
+01:26:29,640 --> 01:26:37,330
+الآن high autosomal resistance storyالـ story مش
+
+911
+01:26:37,330 --> 01:26:41,770
+مهمة، يعني بالأخير واحد ياخد الفكرة إذا أتزامل،
+
+912
+01:26:41,770 --> 01:26:47,070
+what is the probability that the unborn child will
+
+913
+01:26:47,070 --> 01:26:51,610
+inherit one or more؟ يعني هل هو heterozygous or
+
+914
+01:26:51,610 --> 01:26:55,310
+homozygous for the disease؟ راح يكون بما أن ال
+
+915
+01:26:55,310 --> 01:26:58,810
+disease موجود في العائلة وال two parents are
+
+916
+01:26:58,810 --> 01:27:03,510
+carriers فboth are obligate heterozygous، لازم
+
+917
+01:27:03,510 --> 01:27:10,370
+يكونوا heterozygousفبكون 75% المثال اللي حاطينه
+
+918
+01:27:10,370 --> 01:27:17,590
+هنا 47 الـ pedigree لـ X-linked recesses ولد أو
+
+919
+01:27:17,590 --> 01:27:23,750
+شاب أو حدا وخاله مصابين فالواحد وخاله لما بتشوفهم
+
+920
+01:27:23,750 --> 01:27:31,290
+هدولة X-linked recesses الـ high female جاي بـ two
+
+921
+01:27:31,290 --> 01:27:35,900
+down syndromeفهي مش Non-disjunction عمرها 26 سنة
+
+922
+01:27:35,900 --> 01:27:42,220
+يعني صغير بالعمر فمش Non-disjunction فالسبب إذا
+
+923
+01:27:42,220 --> 01:27:46,160
+بتصير هذه اللي هي Reciprocal Translocation مع
+
+924
+01:27:46,160 --> 01:27:51,660
+Chromosome 21 عادة بركب على Chromosome 14 فهي
+
+925
+01:27:51,660 --> 01:27:57,260
+عندها بتعطي أولادها Two copies of Chromosome 22
+
+926
+01:27:57,260 --> 01:28:02,690
+و21يعني والأب بيعطي one copy فبصير down syndrome
+
+927
+01:28:02,690 --> 01:28:10,150
+هاي زيادة a man with hemophilia A له X-linked
+
+928
+01:28:10,150 --> 01:28:16,950
+recessive والذوج واحدة heterozygous
+
+929
+01:28:16,950 --> 01:28:23,690
+career ف what proportion فالزلمة ال X تبعه مصاب
+
+930
+01:28:23,690 --> 01:28:28,650
+وال Y طبيعي أو ال Y مالوش دخلزوج واحدة عندها طبيعي
+
+931
+01:28:28,650 --> 01:28:35,850
+ومصاب فالابنات تبعتهم اللي
+
+932
+01:28:35,850 --> 01:28:41,930
+بيكون فيه نسبة خمسين بالمية بيكونوا مصابين وخمسين
+
+933
+01:28:41,930 --> 01:28:46,810
+بالمية بيكونوا Carriers لازم يكون هيك الـ Marfan
+
+934
+01:28:46,810 --> 01:28:54,400
+Syndrome اللي هي Autosomal Dominant وصار عندهابينت
+
+935
+01:28:54,400 --> 01:28:58,340
+في عائلة ودورت في كل العائلة ما في حد عنده مثل هذا
+
+936
+01:28:58,340 --> 01:29:03,800
+الشيء فهذه البنت أخدتها من الـ New Mutation صارت
+
+937
+01:29:03,800 --> 01:29:12,020
+في أحد أبويها اللي هي الـ D وخمسين اللي هو اسمه
+
+938
+01:29:12,020 --> 01:29:16,340
+Miss Sense Mutation اللي بعطيني هذا الشيء أنا مضطر
+
+939
+01:29:16,340 --> 01:29:22,670
+عندي تدريس ثاني إذا في أسئلة على الـ Geneticsهذه
+
+940
+01:29:22,670 --> 01:29:26,850
+كلها من المرجع تطلعوا عليه وإن شاء الله المرات
+
+941
+01:29:26,850 --> 01:29:31,110
+الجاية برضه راح ناخد محاضرات تبقى نسوي revision من
+
+942
+01:29:31,110 --> 01:29:35,550
+خلال أسئلة وده في عندكم أسئلة عامة ماشي دكتور أحمد
+
+943
+01:29:35,550 --> 01:29:40,170
+أنا مضطر أطلع الآن عشانك يا دكتور مشكور جدا على
+
+944
+01:29:40,170 --> 01:29:44,530
+يعني وقتك اللي … لا هذا واجب مافي مشكلة إن شاء
+
+945
+01:29:44,530 --> 01:29:49,120
+الله نكون بنفيد والـWhatsApp groupالـ WhatsApp
+
+946
+01:29:49,120 --> 01:29:54,120
+Group إذا حد بخطللي سؤال عليه يعني أخوة وأخوات
+
+947
+01:29:54,120 --> 01:30:02,320
+زملاء كتير بودولي على الخاص إلي لوحدي فيعني ما في
+
+948
+01:30:02,320 --> 01:30:08,660
+مشكلة دايماً بطلب إنه ابعته على التبعين الكل وأنا
+
+949
+01:30:08,660 --> 01:30:15,040
+يعني على طول إذا بشوف أي سؤال برد عليه وخلّينا نرد
+
+950
+01:30:15,040 --> 01:30:20,370
+من خلال الـ Groupويخلّيها الواحد على الأسئلة أما
+
+951
+01:30:20,370 --> 01:30:26,570
+ان داخل مش داخل شرحته وما شرحتوش هذا بنفع هذا
+
+952
+01:30:26,570 --> 01:30:32,010
+بنفعش ما ندخلش في هذا السهل يعني واجبي وزي ما
+
+953
+01:30:32,010 --> 01:30:35,430
+اتفضل الدكتور أحمد أنه من خلال الانتحار الواحد
+
+954
+01:30:35,430 --> 01:30:39,910
+كمان بتعلم يعني أنا مابتذكرشالأسئلة اللي جوابتها
+
+955
+01:30:39,910 --> 01:30:43,950
+صح في المواد بس اللي عارق في مخي أكتر من اليوم مرة
+
+956
+01:30:43,950 --> 01:30:48,610
+الأشياء اللي جوابتها غلط وعارفت ليش جوابتها غلط
+
+957
+01:30:48,610 --> 01:30:53,510
+خلوا أحد جزء من الدراسة نشوف المراجع أنا المراجع
+
+958
+01:30:53,510 --> 01:30:57,630
+اللي فيها أسئلة ماقدتش أبدأ فيها من ناحية إنه
+
+959
+01:30:57,630 --> 01:31:02,770
+خلّينا ناخد شوية يعني خميرة من المعلومات العلمية
+
+960
+01:31:02,770 --> 01:31:08,880
+وأخيرًا يعني تفاصيل الأمراض، هاي إن شاء اللهعندكم
+
+961
+01:31:08,880 --> 01:31:13,980
+طريق طويل تاخدوها بعدين يالله يعطيكم العافية يعطيك
+
+962
+01:31:13,980 --> 01:31:17,820
+ألف عافية دكتور الله يحييكم نشوفكم يوم الأربعة ان
+
+963
+01:31:17,820 --> 01:31:22,920
+شاء الله رب العالمين يعطيكم العافية دكاترة نشوفكم
+
+964
+01:31:22,920 --> 01:31:23,600
+ان شاء الله يوم الأولى
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/DpkVcBuiaNg.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/DpkVcBuiaNg.srt
new file mode 100644
index 0000000000000000000000000000000000000000..a024eb24036cbbd570ea057927116ff83c3e6129
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/DpkVcBuiaNg.srt
@@ -0,0 +1,2571 @@
+1
+00:00:00,000 --> 00:00:04,560
+في آخر المحاضرة الأخيرة، احنا استعجلنا شوية هيك بس
+
+2
+00:00:04,560 --> 00:00:11,360
+أظن كانت المفاهيم واضحة، ويعني الواحد يعني بالنسبة
+
+3
+00:00:11,360 --> 00:00:21,320
+للطب الحديث الآن، بتلاقي الإنسان يعني إمكانية إذا
+
+4
+00:00:21,320 --> 00:00:27,380
+في إمكانيات طبية وصحية في البلاد المتقدمة، يعني إنه
+
+5
+00:00:27,380 --> 00:00:31,820
+فعلاً النظام الصحي يعتني بكل إنسان حسب احتياجه وحسب
+
+6
+00:00:31,820 --> 00:00:36,960
+أمراضه وحسب تاريخه المرضي، يعني حتى كـ Family
+
+7
+00:00:36,960 --> 00:00:40,960
+History و Genetic Testing و كذا، والآن
+
+8
+00:00:40,960 --> 00:00:45,540
+الأدوات والآلات إذا موجودة، وممكن يعني الإمكانات
+
+9
+00:00:45,540 --> 00:00:50,270
+موجودة، هتلاقي أمور جميلة، ممكن الواحد إذا بعرفها
+
+10
+00:00:50,270 --> 00:00:56,050
+يسويها، والكلام بشكل أساسي للأخوة والأخوات الطالبات
+
+11
+00:00:56,050 --> 00:01:02,650
+والطلاب، المحاضرة الأخيرة حسب الكتاب، عشان إن شاء
+
+12
+00:01:02,650 --> 00:01:10,750
+الله المرات القادمة، نسير يعني نراجع الأسئلة
+
+13
+00:01:10,750 --> 00:01:11,350
+التبعية
+
+14
+00:01:13,920 --> 00:01:20,620
+تبعات الـ USMLE أو غيرهم من المراجع الثانية إن شاء
+
+15
+00:01:20,620 --> 00:01:24,480
+الله، بيكون احنا يعني عند كل واحد بيقرأ هذه الأسئلة
+
+16
+00:01:24,480 --> 00:01:32,640
+يعني نوع من الفهم، وممكن أهو يكون فعلاً تمتحن لقدرات
+
+17
+00:01:32,640 --> 00:01:38,060
+الطالب والدكتور بشكل جيد، حول المناعة اليوم،
+
+18
+00:01:38,060 --> 00:01:44,370
+المحاضرة، حقيقة الفصل الأخير بصراحة من أهم الفصول
+
+19
+00:01:44,370 --> 00:01:51,430
+وأنا أعتبرها من أجملها، ولكن بالنسبة لي أنا الـ
+
+20
+00:01:51,430 --> 00:01:57,330
+الـ... بالذات اللي حاطينه هو هم، يعني ما بعبر عن شو
+
+21
+00:01:57,330 --> 00:02:01,840
+هيك، طموحي أنه نتناقش في هذه الجوانب، الجوانب
+
+22
+00:02:01,840 --> 00:02:07,300
+الأخلاقية، والجوانب الاجتماعية، والجوانب الفكرية في
+
+23
+00:02:07,300 --> 00:02:13,800
+طب الوراثة، فالاسم الفصل الأخير في الكتاب قبل ما
+
+24
+00:02:13,800 --> 00:02:17,580
+يدخل في الأمراض وتفاصيلها، «ethical and social
+
+25
+00:02:17,580 --> 00:02:23,340
+issues in genetics and genomics»، فحقيقة يعني هذا
+
+26
+00:02:23,340 --> 00:02:30,240
+جانب، أنا راح أحط مقدمتين، ثلاث حتى على الأقل
+
+27
+00:02:30,240 --> 00:02:35,720
+لخلفية كل واحد مننا، الإسلامية، العربية، منطقة الشرق
+
+28
+00:02:35,720 --> 00:02:42,040
+الأوسط، في هذا المكان تكون الأمور واضحة، ويكون
+
+29
+00:02:42,040 --> 00:02:50,920
+الواحد عنده مبادئ أو نقاط ثابتة أو أسس ثابتة
+
+30
+00:02:50,920 --> 00:02:56,080
+بينطلق منها في التعامل في هذه الجوانب، الجوانب
+
+31
+00:02:56,080 --> 00:03:02,380
+الأخلاقية، صراحة من أهم الجوانب، وحقيقة الطب يعني
+
+32
+00:03:02,380 --> 00:03:08,560
+وأنا دائماً بقول لطلابي: إحنا بقوسين، وظيفتكم الآن
+
+33
+00:03:08,560 --> 00:03:14,400
+تتعلموا، فاحنا مطلوب منا أن نعلمكم ما هو مطلوب، بس أن
+
+34
+00:03:14,400 --> 00:03:18,160
+أعلمكم التشريح والعلوم الطبية، وكيف تتعامل مع
+
+35
+00:03:18,160 --> 00:03:24,230
+المريض وكذا، فيه جوانب أخلاقية لازم تتعلموها، ولازم
+
+36
+00:03:24,230 --> 00:03:28,130
+تعرفوها، فحقيقة
+
+37
+00:03:28,130 --> 00:03:34,110
+أنا أظن أنه على الأقل، الحمد لله، بالنسبة لنا كمسلمين
+
+38
+00:03:34,110 --> 00:03:41,330
+وعرب، أن تاريخنا والوضوح
+
+39
+00:03:41,330 --> 00:03:48,390
+كبير جداً، وإن كان حتى قبل الإسلام وقبل العرب، هناك
+
+40
+00:03:48,390 --> 00:03:53,580
+مبادئ عالمية يشترك فيها الناس كلها، فيه شوية جوانب
+
+41
+00:03:53,580 --> 00:03:59,400
+الأخلاقية في الطب ابتداءً، وبعد ذلك أكثر في الـ
+
+42
+00:03:59,400 --> 00:04:04,080
+وراثة وعلوم الوراثة، والإمكانات الحديثة، وكيف
+
+43
+00:04:04,080 --> 00:04:09,420
+الواحد يتعامل مع هذه الجوانب، المقدمتين اللي كنت
+
+44
+00:04:09,420 --> 00:04:16,260
+حابب أني أذكرهم، أولاً، يعني أنا أظن كل واحد منكم
+
+45
+00:04:16,260 --> 00:04:21,890
+بيعرف أنّه مجرد ما تتخرج من الجامعة، وإن شاء
+
+46
+00:04:21,890 --> 00:04:27,290
+الله في حفلة التخرج، بتقسم هذا القسم، حقيقة قسم مهم
+
+47
+00:04:27,290 --> 00:04:34,970
+وأقرأه، ويعني هذا القسم جزء كبير منه مأخوذ حتى من ما
+
+48
+00:04:34,970 --> 00:04:39,750
+يسمى قسم أبقراط، أبو قراط، اللي هو يعتبر من الأسور
+
+49
+00:04:39,750 --> 00:04:46,710
+اليونانية، يعني قبل ميلاد سيدنا المسيح بكذا، 400
+
+50
+00:04:46,710 --> 00:04:52,570
+سنة، 500 سنة على الأقل، لقى مشهور وبيتكلم عن نفس
+
+51
+00:04:52,570 --> 00:04:56,650
+المبادئ، وإن كان يعني إذا حد قرأ نفس القسم القديم
+
+52
+00:04:57,020 --> 00:05:02,380
+هتلاقي إنه بيتكلم إنه بيحلف في أبولو، ملك إله الطب
+
+53
+00:05:02,380 --> 00:05:08,360
+يعني بيخبص تخبصاته، بس المبادئ الأساسية، فإحنا لما
+
+54
+00:05:08,360 --> 00:05:12,820
+الواحد مننا يقسم، يقسم بالله العظيم أن أراقب الله
+
+55
+00:05:12,820 --> 00:05:17,560
+في مهنتي، وأن أسعى لحياة الإنسان في كافة أدواره في
+
+56
+00:05:17,560 --> 00:05:22,760
+كل الظروف والأحوال، باذلاً وسعي لاستنقاذها من الهلاك
+
+57
+00:05:22,760 --> 00:05:28,570
+والمرض والألم والقلق، مطلوب منه أن أحافظ على الإنسان
+
+58
+00:05:28,570 --> 00:05:32,590
+اللي أمامنا من الهلاك والمرض والألم والقلق، وأن
+
+59
+00:05:32,590 --> 00:05:38,310
+أحفظ للناس كرامتهم، وأستر عورتهم، وأكتم سرهم، وأن
+
+60
+00:05:38,310 --> 00:05:42,470
+أكون على الدوام من وسائل رحمة الله، بادلاً رعاية
+
+61
+00:05:42,470 --> 00:05:47,810
+طبية للقريب والبعيد، للصديق والعدو، وأن أثابر على طلب العلم، وسأسخره لدفع
+
+62
+00:05:47,810 --> 00:05:52,710
+الضرر عن الإنسان، لا لأذاه، وأن أوقر من علمني، وأعلم من
+
+63
+00:05:52,710 --> 00:05:57,570
+يصغرني، وأكون لكل زميل في المهنة الطبية
+
+64
+00:05:57,570 --> 00:06:01,590
+متعاوناً على البر والتقوى، وأن تكون حياتي مصداقاً
+
+65
+00:06:01,590 --> 00:06:07,030
+ليماني في سري، وعلى نيتي نقية مما يشينها تجاه الله
+
+66
+00:06:07,030 --> 00:06:12,550
+ورسوله والمؤمنين، الله على ما أقول شهيد، عقيقة، يعني
+
+67
+00:06:17,270 --> 00:06:23,810
+مبادئ، أنا بعتبر حفظ كرامة الإنسان، حفظ سر الإنسان،
+
+68
+00:06:24,280 --> 00:06:32,820
+حفظ الإنسان من الهلاك والمرض والألم والقلق، والتعامل
+
+69
+00:06:32,820 --> 00:06:36,640
+مع الزملاء وغيرها، هذه المبادئ الأخلاقية العامة
+
+70
+00:06:36,640 --> 00:06:44,960
+الطبية، وهي مشمولة في القسم، حقيقة لازم الواحد يكون
+
+71
+00:06:44,960 --> 00:06:51,280
+متنبهاً لها، ويكون مطبقاً لها، يعني يتشربها ويعتبرها
+
+72
+00:06:51,280 --> 00:06:58,590
+مبادئ تحكم تفكيره، وتحكم يعني تصرفاته، يعني ما بيصير
+
+73
+00:06:58,590 --> 00:07:02,630
+الواحد يكون مثلاً، فقط وظيفته: أنا بدي أصبح دكتور
+
+74
+00:07:02,630 --> 00:07:09,930
+عشان أجمع مصاري، وأجرم الناس جرم بالمصاري، وأكون احتم
+
+75
+00:07:09,930 --> 00:07:16,530
+مريض، بدفع ودفع، وعنده مصاري أدور عليه، وأتقاتل أنا
+
+76
+00:07:16,530 --> 00:07:21,900
+والملاقمين، راح يعمل العملية، ومين راح يعالج هذا
+
+77
+00:07:21,900 --> 00:07:28,260
+المريض، ولا كذا ولا كذا، فحقيقة قسم
+
+78
+00:07:28,260 --> 00:07:33,960
+الطبيب من الأول، وهذا ستأخذونه إن شاء الله في حفلة
+
+79
+00:07:33,960 --> 00:07:39,380
+التخرج، أتوقع هيقعد في الدنيا كلها، إنه كل واحد يجب
+
+80
+00:07:39,380 --> 00:07:44,120
+أن يقسم هذا، ويجب الواحد منا أن يعتبر هذا القسم
+
+81
+00:07:44,120 --> 00:07:49,480
+والميثاق، بينه وبين الله الذي يراقبه بالسر والعلن،
+
+82
+00:07:49,480 --> 00:07:56,720
+لوحدك، ولا مع غيرك ولا كذا، لما
+
+83
+00:07:56,720 --> 00:08:01,660
+تكون طبيب، تتعامل معه، إن شاء الله تكون المفاهيم
+
+84
+00:08:01,660 --> 00:08:05,620
+واضحة، وإذا في حد عنده استفسار، يا دكتور أحمد يكلمني
+
+85
+00:08:05,620 --> 00:08:13,740
+ماشي، يعني الواحد بيكمل المحاضرة، لما
+
+86
+00:08:13,740 --> 00:08:24,090
+تتعاملوا، ترى بعد ذلك ما الذي يحكمك، ما الذي يعني أنت
+
+87
+00:08:24,090 --> 00:08:32,350
+مطالب بتنفيذه، وتنفيذه في حياتك
+
+88
+00:08:32,350 --> 00:08:41,810
+الطبية كطبيب في المجتمع، هناك يعني من الـ يمكن في
+
+89
+00:08:41,810 --> 00:08:47,150
+فترة، أن يكون الطالب يعني
+
+90
+00:08:47,150 --> 00:08:53,630
+في أعلى مقاعد الدراسة، قد لا يكون عنده احتكاك، وتفهم
+
+91
+00:08:53,630 --> 00:09:01,850
+ويعني، وتطبيق لجوانب مفروض أساسية يكون الواحد فاهمها،
+
+92
+00:09:01,850 --> 00:09:12,130
+إحنا في أي بلد، هناك قانون للصحة، وهناك شيء اسمه
+
+93
+00:09:12,130 --> 00:09:18,470
+قانون الصحة، زي قانون السير، زي قانون وزارة التعليم،
+
+94
+00:09:18,470 --> 00:09:21,750
+وعنا يعني في الأردن، لا أعرف إيش كان النظام في
+
+95
+00:09:21,750 --> 00:09:27,590
+غزة، بالنسبة كتطبيق، يعني اللي هناك تلات أو أربع
+
+96
+00:09:27,590 --> 00:09:32,650
+درجات من الأنظمة، والأشياء اللي احنا بنفتقر لها،
+
+97
+00:09:32,650 --> 00:09:38,080
+يعني بالأخير، والله أنا بسوق بالسيارة، دخلت عدوار،
+
+98
+00:09:38,080 --> 00:09:42,380
+دا عامة، بس يقول عليك أنت الحق، يقول لك لأ أنت عليك
+
+99
+00:09:42,380 --> 00:09:46,780
+الحق، احنا بنحتكم لقانون، حتى لو ما انتبهناش، بس
+
+100
+00:09:46,780 --> 00:09:51,580
+احنا محكمين بالقانون، ولا بتصير حياة البشر غابة،
+
+101
+00:09:51,580 --> 00:09:58,300
+فالقانون طبعاً، أعلى قوانين أي مجتمع، ما يسمى دستور،
+
+102
+00:09:59,300 --> 00:10:02,440
+يمكن في غزة، ما أعرف كيف النظام، يكون، مائي بالمائي،
+
+103
+00:10:02,440 --> 00:10:07,680
+بس بحكي عن الأردن، الدستور الأردني، الدستور هو يعني
+
+104
+00:10:07,680 --> 00:10:12,220
+شيء، حتى في أمريكا، الدستور الأمريكي، وتعديلاته وكذا،
+
+105
+00:10:12,220 --> 00:10:16,620
+وكذا، كان المبادئ الحاكمة الأساسية للعقد الاجتماعي
+
+106
+00:10:16,620 --> 00:10:23,500
+للمجتمع بأكمله، فالدستور يعني هو أساس القوانين
+
+107
+00:10:23,500 --> 00:10:30,890
+جميعاً، وبالتالي هو الذي يعني يحكم كل شيء، ويكون فيه
+
+108
+00:10:30,890 --> 00:10:37,270
+مبادئ عامة تمثل هوية المجتمع، وهوية الدولة، ومبادئها
+
+109
+00:10:37,270 --> 00:10:41,750
+وقيمها، وجوانب تفصيلية أخرى للقضايا الكلية، زي ما
+
+110
+00:10:41,750 --> 00:10:47,630
+بقول، القانون يعني بيجي بعد الدستور، هناك القوانين،
+
+111
+00:10:48,200 --> 00:10:52,380
+القوانين زي قانون الصحة، قانون السير، قانون
+
+112
+00:10:52,380 --> 00:10:56,860
+العقوبات، قانون الجوانب
+
+113
+00:10:56,860 --> 00:11:01,240
+الكثيرة هنا، القانون الاقتصادي، القانون إنه هو
+
+114
+00:11:01,240 --> 00:11:10,890
+الشيء الذي، أو الأحكام، أو المنظمة لنا، اللي يعني في
+
+115
+00:11:10,890 --> 00:11:16,310
+الأردن، تقترحها الحكومة، ليوافق عليها البرلمان
+
+116
+00:11:16,310 --> 00:11:21,470
+البرلمان اللي هو يعني، المجلس النواب، ومجلس الأعيان
+
+117
+00:11:21,470 --> 00:11:27,190
+إنها برلمانين، وبعد ذلك، بس يتم الموافقة عليها، والكل
+
+118
+00:11:27,190 --> 00:11:31,970
+يشترك في الموافقة عليها، تُوشّح بإرادة ملكية، ورئيس
+
+119
+00:11:31,970 --> 00:11:37,690
+الدولة أو الحكم، يوافق عليها، فهي يعني، أعلى بعد
+
+120
+00:11:37,690 --> 00:11:42,490
+الدستور، تيجي مرتبة ثانية، بعدين هناك ما يسمى
+
+121
+00:11:42,490 --> 00:11:47,850
+الأنظمة، الأنظمة، ونظام زي مثلاً، نظام جامعة العلوم
+
+122
+00:11:47,850 --> 00:11:54,580
+والتكنولوجيا، شايف  عليك؟ فالنظام هو يعني برضه
+
+123
+00:11:54,580 --> 00:12:01,320
+تعليمات نابعة من قانون، بقوم الوزير، هو يعني صلاحية
+
+124
+00:12:01,320 --> 00:12:05,740
+الوزير، لما إننا بدنا نغير في النظام شيء، الوزير هو
+
+125
+00:12:05,740 --> 00:12:10,240
+اللي بيقدر يغير، ما فيش داعي لمدّس نواب، ومدّس أعيان،
+
+126
+00:12:10,240 --> 00:12:15,540
+وإرادة ملكية، والمبادئ، هذا القانون، وبعدين في
+
+127
+00:12:15,540 --> 00:12:21,180
+داخل المؤسسة، يعني هذه اللي مثلاً عندنا وزير التعليم
+
+128
+00:12:21,180 --> 00:12:27,600
+العالي، بيصدر، بيسموه نظام الجامعات، أو نظام كذا، لأن
+
+129
+00:12:27,600 --> 00:12:30,780
+احنا اللي بنحكم فيه، وبعدين المستوى الأخير بيسموه
+
+130
+00:12:30,780 --> 00:12:35,020
+التعليمات، التعليمات، يعني أي مؤسسة زي جامعة العلوم
+
+131
+00:12:35,020 --> 00:12:39,740
+والتكنولوجيا، الهندسية، عندها تعليمات ترقية أعضاء
+
+132
+00:12:39,740 --> 00:12:44,220
+الهيئة التدريسية، تعليمات نظام الإجازات، أو تعليمات
+
+133
+00:12:44,220 --> 00:12:48,880
+الإجازات في هذه المؤسسة، المهم، يعني الفكرة في هذا
+
+134
+00:12:48,880 --> 00:12:53,880
+الموضوع، إنه الواحد مننا بده يكون متنبهاً لهذه
+
+135
+00:12:53,880 --> 00:12:58,700
+الأهمية، هذه الجوانب، بقول، عشان هيك يعني، البرلمانات،
+
+136
+00:12:58,700 --> 00:13:02,520
+شيء مهم، إحنا ما نأخذها إن والله، هاي سياسي، وشكلي،
+
+137
+00:13:02,520 --> 00:13:07,480
+وما لهاش دخل، إحنا محكمين فيها، احنا كأشخاص، قانون
+
+138
+00:13:07,480 --> 00:13:10,560
+السير بيمشي عليّ، لو في شيء غلط بقانون السير،
+
+139
+00:13:10,560 --> 00:13:13,840
+المفروض يُعدّل، يعني مش هذا الشيء الكبير، يعني
+
+140
+00:13:13,840 --> 00:13:19,410
+والسياسة، 90% منها بتنظيم حياة الناس، بتكون أشياء
+
+141
+00:13:19,410 --> 00:13:23,790
+يعني مش سهلة منك تتفق، أجمع عقول الناس
+
+142
+00:13:23,790 --> 00:13:28,710
+الكبيرة فيها، يعني، فكل
+
+143
+00:13:28,710 --> 00:13:34,030
+بلد لها قوانين، وبدّ الواحد يكون فاهم شو قانون
+
+144
+00:13:34,030 --> 00:13:38,150
+البلد اللي أنا فيه، قانون الصحة مثلاً، إنه، أو راح
+
+145
+00:13:38,150 --> 00:13:42,250
+نيجي مثلاً، ندخل على، مثلاً، سرية المعلومة، وعدم سرية
+
+146
+00:13:42,250 --> 00:13:48,050
+المعلومة، أنا بقول، احنا الأول، أنا محكوم بقانون الصحة،
+
+147
+00:13:48,050 --> 00:13:52,710
+ثم أمر المحكمة، يعني مثلاً، عندنا في القانون في
+
+148
+00:13:52,710 --> 00:13:58,430
+الأردن، بسبب يعني، تأثيره على الصحة العامة، إنسان
+
+149
+00:13:58,430 --> 00:14:07,050
+عنده سل، إنسان عنده مثلاً التهاب الكبد الوبائي B أو
+
+150
+00:14:07,050 --> 00:14:13,340
+C، الـ Malaria،  مش عارف، هذه أمراض كذا، ثبت إن إنسان
+
+151
+00:14:13,340 --> 00:14:18,600
+عنده هذا المرض، فبالقانون، بالقانون التابع للصحة،
+
+152
+00:14:18,600 --> 00:14:24,360
+هناك تعريف للأمراض التي يجب أن تُبلغ عنها، هو طبعاً
+
+153
+00:14:24,360 --> 00:14:28,300
+يعني عادة، مش الطبيب اللي بيبلغ، بس عادة، حتى المختبر
+
+154
+00:14:28,300 --> 00:14:33,860
+فيه نظام، بيقول في المختبر، إنه لما تكون الحالة
+
+155
+00:14:33,860 --> 00:14:39,430
+الفلانية هي اللي تم تشخيصها، يتم التبليغ، والسبب حتى
+
+156
+00:14:39,430 --> 00:14:43,410
+لو الإنسان أراد أو لم يرد، هناك واجب للمجتمع، يحمي
+
+157
+00:14:43,410 --> 00:14:50,870
+المجتمع، إنه مرته وولاده، جيرانه، يمكن شخص مخالط له،
+
+158
+00:14:50,870 --> 00:14:55,990
+بدك تفحصه، بدك تشوفه، بدك تحميه، بدك تنبهه إنه يعني
+
+159
+00:14:55,990 --> 00:15:00,970
+داخل على حالة مرض، يعني مثلاً، ممكن نقول حتى لو الـ
+
+160
+00:15:00,970 --> 00:15:04,670
+COVID تبعنا في الأيام الأخيرة هذه، يعني بعض الناس
+
+161
+00:15:04,670 --> 00:15:12,780
+إذا أصيبوا، ممكن يعني، أكبر مثال هذا، يعني رئيس الولايات
+
+162
+00:15:12,780 --> 00:15:16,920
+المتحدة الأمريكية، مهمل للموضوع، مش مصدق إنه هذا
+
+163
+00:15:16,920 --> 00:15:22,340
+مرض بيخوف وكذا، لا بديه، بس كان مهمل، وعشان هي
+
+164
+00:15:22,340 --> 00:15:25,200
+كل اللي حواليه، كثير منهم هو انصاب، وغير انصابوا،
+
+165
+00:15:25,200 --> 00:15:32,260
+انتشروا، فهناك قوانين للصحة، الواحد يجب أن يعرف ما
+
+166
+00:15:32,260 --> 00:15:37,300
+هي هذه القوانين اللي بتحكمه، يعني لو في لحظة معينة في
+
+167
+00:15:37,300 --> 00:15:41,400
+مثلاً، إنه قانون للصحة، وقانون لنقابة الأطباء، أو
+
+168
+00:15:41,400 --> 00:15:47,160
+نظام لنقابة الأطباء أظن، وفيه آليات وتعليمات يجب أن
+
+169
+00:15:47,160 --> 00:15:53,520
+الواحد ينتبه للمسميات هذه، ويشوف هو
+
+223
+00:20:39,400 --> 00:20:44,180
+حياته أنه يعني إذا مثلاً بعرف الواحد في مرض اسمه
+
+224
+00:20:44,180 --> 00:20:49,320
+مرض ويجنر، ويجنر-granulomatosis هذا، ويجنر عالم
+
+225
+00:20:49,320 --> 00:20:54,200
+ألماني وهو يعني يعني دقيق جداً، وأبحاثه من أجمل
+
+226
+00:20:54,200 --> 00:21:00,440
+الأبحاث وكده، شو اسمه؟ كان يعني أجرم في اليهود وكان
+
+227
+00:21:00,440 --> 00:21:06,380
+من الذين حُكموا في محاكمات Nuremberg هذه، محاكمات
+
+228
+00:21:06,380 --> 00:21:11,140
+مشهورة كانت للأطباء والعلماء بعد الحرب العالمية
+
+229
+00:21:11,140 --> 00:21:15,140
+الثانية، وأنتجت عنها أنه كان المفروض أن تأخذ
+
+230
+00:21:15,140 --> 00:21:19,980
+موافقة الإنسان اللي أنت بدك تعمل عليه تجربة، كان
+
+231
+00:21:19,980 --> 00:21:27,290
+المفروض مثلاً تعمل كده تعمل كده، فالـ هناك مبادئ
+
+232
+00:21:27,290 --> 00:21:34,190
+للأبحاث الطبية، يعني أنت الأصل أنك أنت تعمل العلاج
+
+233
+00:21:34,190 --> 00:21:38,690
+وتتعامل مع المريض لمصلحة هذا المريض، لما أنت بدك
+
+234
+00:21:38,690 --> 00:21:42,730
+تعمل بحث، أنت ما بتفوّت الشغل لأنك عارف أنك أنت
+
+235
+00:21:42,730 --> 00:21:48,350
+بتعالج هذا المريض، إنما أنت تعمل التجربة عشان تفيد
+
+236
+00:21:48,350 --> 00:21:54,110
+المجتمع، عشان تفيد البشرية، فبالتالي الأبحاث الطبية
+
+237
+00:21:55,070 --> 00:22:02,650
+منها أنه لازم البحث يأخذ موافقة اللي يسمّونه IRB، الـ
+
+238
+00:22:02,650 --> 00:22:08,290
+Institutional Review Board، يعني لجنة تقييم
+
+239
+00:22:08,290 --> 00:22:14,050
+أخلاقيات البحث، هل هذا البحث يعني أنا إذا بعمل
+
+240
+00:22:14,050 --> 00:22:18,470
+تجربة وما لهاش قيمة علمية، حرام، ليش أعملها؟ لازم
+
+241
+00:22:18,470 --> 00:22:23,080
+يكون إن فيه قيمة علمية، ومش الباحث نفسه اللي بيقرر
+
+242
+00:22:23,080 --> 00:22:25,960
+أنه هي لها قيمة علمية، غيره لازم نقوله «آه والله
+
+243
+00:22:25,960 --> 00:22:29,620
+باحثك هذا كويس، اعمله»، يعني أنا بتيجي إن استشارات
+
+244
+00:22:29,620 --> 00:22:32,860
+مثلاً مرات أنه شو رأيك؟ وأنا والله عندي كده، بدي
+
+245
+00:22:32,860 --> 00:22:37,340
+أعمل كده، نعمل ولا ما نعملش، غيره لازم نقول غير
+
+246
+00:22:37,340 --> 00:22:40,860
+الباحث، الباحث ده ممكن بده شهرة، بده يجيب براءة،
+
+247
+00:22:40,860 --> 00:22:45,840
+بده كده، بعمل الشغل، فبالتالي الأبحاث الطبية اللي
+
+248
+00:22:45,840 --> 00:22:50,220
+لها مبادئ، وبده الواحد لما يشتغل فيها يكون عارف شو
+
+249
+00:22:50,220 --> 00:22:56,880
+هي المبادئ، ويتطبّقها، ويتعامل معاها، الحاكم
+
+250
+00:22:56,880 --> 00:23:02,720
+الرابع لتعامل الواحد، هي قضية أنا بشتغل في مؤسسة
+
+251
+00:23:02,720 --> 00:23:07,340
+يعني أنا بشتغل في جامعة العلوم والتكنولوجيا
+
+252
+00:23:07,340 --> 00:23:11,640
+الأردنية، موظفة فيها، وفي مستشفى الملك المؤسس في
+
+253
+00:23:11,640 --> 00:23:17,220
+إربد أو في الرمثا شمال الأردن، فالمؤسسة
+
+254
+00:23:17,220 --> 00:23:22,930
+أنا تعاقدت معاها، فعقدت عقد، إذا ما التزمت أنا بالعقد
+
+255
+00:23:22,930 --> 00:23:27,930
+لهم حق يعاقبوني، وأحياناً يعني في مُحددات حتى إضافية
+
+256
+00:23:27,930 --> 00:23:31,910
+غير المبادئ القانونية العامة من المؤسسة التابعة لها،
+
+257
+00:23:31,910 --> 00:23:36,730
+إذا ما التزمت فيها أنت مش ناجح، أنت مش يعني مُخَلِّص
+
+258
+00:23:36,730 --> 00:23:40,890
+يعني مش مش أنت علاج سبب في التأخر، سبب في التخلّف،
+
+259
+00:23:40,890 --> 00:23:45,890
+سبب في النزاع، سبب في الشفاقة، الأصل أنه أنا أكون
+
+260
+00:23:45,890 --> 00:23:50,290
+عارفة نظام المؤسسة اللي أنا بشتغل فيه، وإني وافقت
+
+261
+00:23:50,290 --> 00:23:56,490
+عليه، وبتعامل معاه، يعني صراحة من أجمل الأمثلة، ومش
+
+262
+00:23:56,490 --> 00:24:00,430
+غلط الواحد دائماً يذكر الخير لأهله، أنا روحت على
+
+263
+00:24:00,430 --> 00:24:05,530
+أمريكا بالـ 91، وأول مرة يعني أنا كنت في الكويت
+
+264
+00:24:05,530 --> 00:24:09,390
+وإنّا أتجرب في مجتمع قريب من غزة في الكويت، كيف
+
+265
+00:24:09,390 --> 00:24:13,790
+الناس بتتعامل، مرات كثير في أشياء كثيرة إحنا عندنا
+
+266
+00:24:13,790 --> 00:24:20,500
+في بلادنا بتروح بتأمن سيارة، بتروح بتتَوظّف في مكان،
+
+267
+00:24:20,500 --> 00:24:25,320
+ولما ودّوني بقيت، هل بتتعامل مع بنك تأخذ قرض،
+
+268
+00:24:25,320 --> 00:24:28,880
+بيبعتوك  صفحة أوراق، والمسؤول بيقول لك وقّع هنا
+
+269
+00:24:28,880 --> 00:24:32,180
+وقّع هنا، وقّع هنا، وقّع هنا، وقّع هنا، وأنت مش قارئ
+
+270
+00:24:32,180 --> 00:24:36,440
+ومش فاهم، ومش عامل أيش، فاهم عليّ؟ أنت ملزم وخلاص
+
+271
+00:24:36,440 --> 00:24:41,280
+وقّع، والله لما كنت في أمريكا، أول ما اشتغلت في
+
+272
+00:24:41,280 --> 00:24:46,980
+المستشفى، وأنا بوقع العقد معهم، اللي انضميت لهم، عطوني
+
+273
+00:24:46,980 --> 00:24:54,760
+ليست أوراق فيها حقوقي وواجباتي بشكل تفصيلي، شو
+
+274
+00:24:54,760 --> 00:24:59,700
+لازم أعمل، وكيف أتصرف، طبعاً يمكن الواحد أولها ما كانش
+
+275
+00:24:59,700 --> 00:25:04,260
+فاهم كثير، بس فعلاً بقلّة تعاملي معهم، فعلاً برجع
+
+276
+00:25:04,260 --> 00:25:13,780
+للمبادئ هذه، وعقدت أخيراً، إحنا مسلمين، حقيقةً النظام
+
+277
+00:25:13,780 --> 00:25:21,220
+الإسلامي هو أرقى وأفضل وأعلى نظام يعني بشري، أنا
+
+278
+00:25:21,220 --> 00:25:25,380
+عشان هيك بقول مثلاً مبادئ حقوق الإنسان، ومبادئ
+
+279
+00:25:25,380 --> 00:25:29,360
+العالمية بفهمها في ضوء الإسلام، هذا قرار شخصي
+
+280
+00:25:29,360 --> 00:25:35,360
+اللي بسمّيه، بس يعني أنا بشوف إنها كثيراً متوافقة مع
+
+281
+00:25:35,360 --> 00:25:40,850
+مبادئ الدين الإسلامي، ومنظمة إله، والواحد يتذكر أنه
+
+282
+00:25:40,850 --> 00:25:46,890
+في الدنيا مش لوحده، يعني ممكن بسهولة الإنسان يسافر
+
+283
+00:25:46,890 --> 00:25:52,090
+يكون حتى في سفره يدخل في بلاد ثانية، بدي يكون البشر
+
+284
+00:25:52,090 --> 00:25:57,310
+يعني، وغير ذلك تكون الحياة غابة، القوي أكل الضعيف،
+
+285
+00:25:57,310 --> 00:26:01,770
+بغير يعني، بتعدي أو ظلم.
+
+286
+00:26:05,210 --> 00:26:10,550
+الإسلام يعني من الأشياء اللي يجب كمسلم وعربي يكون
+
+287
+00:26:10,550 --> 00:26:14,430
+الواحد واضح عنده بالذات في الأمور (بين قوسين)
+
+288
+00:26:14,430 --> 00:26:21,950
+الفقهية، يعني الدين، ديننا، في أشياء علوم غيبية، إذا
+
+289
+00:26:21,950 --> 00:26:25,850
+واحد بيقول ما فيش آخرة، ومش حاسب، أسابي الآخر، وفي جنّة
+
+290
+00:26:25,850 --> 00:26:30,410
+ونار، هو حر طبعاً، هذا الجانب ربنا اللي بعرفه، يعرف
+
+291
+00:26:30,410 --> 00:26:36,280
+شو قلب الواحد، وشو يعني جوا، وفكري الواحد، و ليش الواحد
+
+292
+00:26:36,280 --> 00:26:40,660
+بيستوي هذا الموضوع، بس في الأمور الفقهية، الفقهية
+
+293
+00:26:40,660 --> 00:26:45,180
+لما نقول فقه يعني هذا من المبادئ الجميلة، أنا أمين
+
+294
+00:26:45,180 --> 00:26:48,560
+سر جمعية العلم الطبي الإسلامي في نقاط الأطباء
+
+295
+00:26:48,560 --> 00:26:53,580
+الأردنيين، الفقه
+
+296
+00:26:53,580 --> 00:26:59,930
+هو الجانب العملي من العبادات ومن المبادئ، يعني
+
+297
+00:26:59,930 --> 00:27:06,790
+الجوانب العملية، كيف تصلي، كيف تصوم، أي فقه، كيف
+
+298
+00:27:06,790 --> 00:27:13,410
+تتزوج، كيف تطلق، أي فقه، كيف مثلاً تبيع وتشتري، فقه
+
+299
+00:27:13,410 --> 00:27:19,090
+لأنه أمور عملية، مش علوم غيبية أو علوم يعني فكرية
+
+300
+00:27:19,090 --> 00:27:25,310
+مطلوبة من الإنسان، والإيمان مطلوب وضروري على الأقل
+
+301
+00:27:25,310 --> 00:27:30,320
+إيمان بالجنة والنار، والحساب، والإيقاف في القيامه
+
+302
+00:27:30,320 --> 00:27:37,720
+يقال هناك فيه مقاصد وقواعد، المقاصد يجمعها قضية
+
+303
+00:27:37,720 --> 00:27:43,680
+مهمة هي الضروريات الخمسة، يعني إحنا لما نتعامل
+
+304
+00:27:43,680 --> 00:27:50,700
+الإسلام بينظر ضرورة المحافظة على الدين، على الحياة
+
+305
+00:27:50,700 --> 00:27:57,960
+أو النفس، على العقل، على العرض، وعلى المال، والحقوق
+
+306
+00:27:59,630 --> 00:28:04,710
+ماشي، فهذه مقاصد الشريعة الإسلامية، يقول لك ما بجزء
+
+307
+00:28:04,710 --> 00:28:08,950
+منك تأخذ فلساً من بني آدم آخر، إذا ما هو راضٍ وعن
+
+308
+00:28:08,950 --> 00:28:16,630
+طيب خاطر وعن قناعة، غير هيك إذا ما يعني، فهذه مقاصد
+
+309
+00:28:16,630 --> 00:28:21,370
+الشريعة للحفاظ على هذه الأمور، والحفاظ على الصحة هو
+
+310
+00:28:21,370 --> 00:28:28,340
+من مقاصد الحفاظ على الحياة، فالـ يعني يكفي الإنسان
+
+311
+00:28:28,340 --> 00:28:35,480
+فقرة، إن الله سبحانه وتعالى في يعني بعد ذكر قصة قابيل
+
+312
+00:28:35,480 --> 00:28:40,320
+وقابيل في القرآن الكريم، يعني بذكر من أجل ذلك كتبنا
+
+313
+00:28:40,320 --> 00:28:46,000
+على بني إسرائيل أنه من قتل نفساً بغير نفس فكأنه
+
+314
+00:28:46,000 --> 00:28:49,920
+فكأنه قتل الناس جميعاً، ومن أحياها فكأنه أحيى
+
+315
+00:28:49,920 --> 00:28:54,160
+الناس جميعاً، أظن أني ممكن خربطت الآية شوية، بس ومن
+
+316
+00:28:54,160 --> 00:28:59,750
+أحياه فكأنما أحيى الناس جميعاً، يعني يوم من قتل
+
+317
+00:28:59,750 --> 00:29:02,790
+قابيل، يعني الواحد يقول نصف البشرية، ربع البشرية
+
+318
+00:29:02,790 --> 00:29:09,370
+ماتت، الواحد يعني ينقذ حياة إنسان، هذا من مقاصد
+
+319
+00:29:09,370 --> 00:29:14,770
+الشريعة الأساسية، فهناك مقاصد يجب أن يفهمها الواحد
+
+320
+00:29:14,770 --> 00:29:20,410
+ينظر في التراث الإسلامي، ومبادئ عظيمة من القرآن
+
+321
+00:29:20,410 --> 00:29:24,210
+الكريم، القرآن يعني
+
+322
+00:29:25,410 --> 00:29:32,510
+يعني هو رسالة الله إلى البشرية الخالدة، الرسالة
+
+323
+00:29:32,510 --> 00:29:38,670
+يعني أنا بحكي كثير للأصدقاء اللي كنا في أمريكا وفي
+
+324
+00:29:38,670 --> 00:29:45,010
+دول ثانية، مؤتمرات أو غيره، أنه لما نحن نتكلم
+
+325
+00:29:45,010 --> 00:29:51,710
+عن القرآن، الإنجليز أنفسهم، إنجليز شيكسبير اللي هو
+
+326
+00:29:51,710 --> 00:29:57,520
+عاش قبل 400 سنة، بس بتعطيه الكلام اللي ذكره شيكسبير
+
+327
+00:29:57,520 --> 00:30:03,040
+نفسه لا يفهموه، فطبعاً التوراة والإنجيل ما حد بيقدر
+
+328
+00:30:03,040 --> 00:30:05,980
+يقول أنه الآن اللي بين أيديهِم توراة وإنجيل هي
+
+329
+00:30:05,980 --> 00:30:10,120
+توراة وإنجيل اللي نزلت على سيدنا موسى وعيسى عليه
+
+330
+00:30:10,120 --> 00:30:15,080
+السلام، بينما القرآن الكريم محفوظ بحفظ الله سبحانه
+
+331
+00:30:15,080 --> 00:30:20,260
+وتعالى، وكذلك كثير من السنة النبوية محفوظة، ولغتها
+
+332
+00:30:20,260 --> 00:30:24,830
+محفوظة وثابتة إلى يوم القيامة، هذه حقيقة المعجزة
+
+333
+00:30:24,830 --> 00:30:30,230
+الإسلام، إنه يعني شغل ما تغيرت طويل هذا السنين
+
+334
+00:30:30,230 --> 00:30:36,770
+والعقود، وآلاف السنين وهي ثابتة لا تتغير، عندما تتلو
+
+335
+00:30:36,770 --> 00:30:40,730
+القرآن الكريم، فأنت تتلوه كما تلاه سيدنا محمد صلى
+
+336
+00:30:40,730 --> 00:30:45,050
+الله عليه وسلم، في لغة ثابته قبل 200 سنة من
+
+337
+00:30:45,050 --> 00:30:51,090
+الإسلام، فمقاصد الشريعة المفروض الواحد يتنبه لها،
+
+338
+00:30:51,090 --> 00:30:58,570
+وقواعدها، هناك قواعد شرعية في الفقه، قواعد فقهية، كأنّا
+
+339
+00:30:58,570 --> 00:31:05,050
+كنا في دورات فقهية، الصراحة يعني فيها أبيات شعر
+
+340
+00:31:05,050 --> 00:31:12,210
+جميلة جداً، ذُكرت لنا، وحفظتها، وأذكركم إياها
+
+341
+00:31:12,210 --> 00:31:20,110
+أحدها، نسيت العالم اللي ذكرها، يقول خمس مقرّرات قواعد
+
+342
+00:31:20,110 --> 00:31:27,770
+مذهب الشافعية، فكُن بهنا علينا، خمس قواعد وهي جملة
+
+343
+00:31:27,770 --> 00:31:32,650
+تعطي قاعدة، تنطبق على مسائل فقهية كثيرة، حتى
+
+344
+00:31:32,650 --> 00:31:38,950
+الواحد يحكم، خمس مقرّرات قواعد مذهب الشافعية فكن بهنا
+
+345
+00:31:38,950 --> 00:31:43,970
+علينا، الإمام الشافعي رضي الله عنه كان من أهم
+
+346
+00:31:43,970 --> 00:31:49,660
+المؤثرين في الفقه، وأصول الفقه، وأصول الدين، وغيرها من
+
+347
+00:31:49,660 --> 00:31:54,460
+المبادئ، حقيقة الإنسان عظيم، فالإمام الشافعي هذا
+
+348
+00:31:54,460 --> 00:31:58,320
+اللي بقوله عن الإمام الشافعي عنده خمس قواعد: ضرر
+
+349
+00:31:58,320 --> 00:32:04,200
+يزال، وعادةٌ قد حُكمت، وكذا المشاقة تجلب التيسيرة،
+
+350
+00:32:04,200 --> 00:32:12,960
+والشك لا يُحكم به متيقناً، وقصدٌ أخلص إن أردت أجرة، هو
+
+351
+00:32:12,960 --> 00:32:19,860
+قواعده اللي هي أنه في الفقه والشرع والدين أولاً أنه
+
+352
+00:32:19,860 --> 00:32:24,100
+لا ضرر ولا ضرار، وحتى في كتابكم الآن هيجيب يقول لك لا
+
+353
+00:32:24,100 --> 00:32:28,660
+ضرر ولا ضرار، يعني هناك طبعاً قواعد شرعية هي قواعد
+
+354
+00:32:28,660 --> 00:32:32,740
+كلية كما يقال، يعني دائماً من القواعد الفقهية
+
+355
+00:32:32,740 --> 00:32:39,490
+تقال أحياناً دفع الضرر مقدم على جلب المنفعة، والله
+
+356
+00:32:39,490 --> 00:32:47,250
+أنا حرّ، بدي أجيب مروحة أحطها عليّ، وأنا عشاني حرّ،
+
+357
+00:32:47,250 --> 00:32:51,050
+يجي واحد بس أنا حرّ شوية، يعني مش مش مشكلة، مش ضارة
+
+358
+00:32:51,050 --> 00:32:57,610
+كبيرة، فينما اللي جنبي عنده رشح أو عنده مرض، فهوية
+
+359
+00:32:57,610 --> 00:33:03,490
+عليه المروحة، هذه القضية تجلب له مرض، فعندها لأ
+
+360
+00:33:03,490 --> 00:33:08,310
+بنقول بنطفي المروحة، بنضويهاش، لأنّه دفع المضرة مقدم
+
+361
+00:33:08,310 --> 00:33:13,490
+على جلب المنفعة، في هذه الطريقة، فضرر يزال، وهذا في
+
+362
+00:33:13,490 --> 00:33:19,050
+حديث الرسول ﷺ لا ضرر ولا ضرار، ويعني من المبادئ أنه
+
+363
+00:33:19,050 --> 00:33:24,710
+لا ضرر ولا ضرار، بعدين وعادةٌ قد حُكّمت، إذا الناس
+
+364
+00:33:24,710 --> 00:33:31,670
+اتفقوا على عادة معينة وما في لها مخالفة شرعية، الأمر
+
+365
+00:33:31,670 --> 00:33:37,520
+يعني يُلتفت له ويُحكم، الإمام الشافعي كان بالعراق
+
+366
+00:33:37,520 --> 00:33:42,000
+كان يحكم بطريقة، ويفتي بطريقة، راح على مصر صار يفتي
+
+367
+00:33:42,000 --> 00:33:45,300
+بطريقة ثانية، قالوا له يا شيخ أنت في العراق كنت تفتي
+
+368
+00:33:45,300 --> 00:33:49,880
+فتوى هيك، قالوا آه كنا في وضع، وكانت فتوى هيك، صرنا في وضع
+
+369
+00:33:49,880 --> 00:33:54,320
+آخر، بنفتي بالطريقة اللي حسبناها، يعني أنا مثلاً مشهورة
+
+370
+00:33:54,320 --> 00:34:00,460
+من الشغلات اللي نذكرها مثلاً الـ dowry عندنا في
+
+371
+00:34:00,460 --> 00:34:07,790
+فلسطين والأردن وكذا ودول كثيرة، معروف المهر بتدفع
+
+372
+00:34:07,790 --> 00:34:13,830
+كل شيء البيت والشقة والأثاث والمهر وكذا، المهر
+
+373
+00:34:13,830 --> 00:34:18,770
+بتدفع كل شيء، هيك عادة الناس، والواحد هو حظه، المهر
+
+374
+00:34:18,770 --> 00:34:28,730
+بده يدفع، إذا زوجة بتتوفى، أما في مصر معروف الشقة
+
+375
+00:34:28,730 --> 00:34:35,020
+على المهر، والأثاث على المرأة، خلاص هي عادة الناس
+
+376
+00:34:35,020 --> 00:34:40,000
+وعرفهم إنهم بيعملوا هيك، ما دام متفقين عليه في الشرع
+
+377
+00:34:40,000 --> 00:34:44,580
+وفي الدين، هذا يصبح أصل شرعي، وعادة قد حُكّمت، فيجب
+
+378
+00:34:44,580 --> 00:34:49,940
+القاضي ولا كده، يحكم حسب عرفها في آية في القرآن، وأمر
+
+379
+00:34:49,940 --> 00:34:53,400
+بالعرف، العرف ما اتفق عليه الناس، حتى ما يصير خلاف
+
+380
+00:34:53,400 --> 00:35:00,020
+ما يصير مشاكل، وعادة قد حُكّمت، وكذا المشاقة تجلب
+
+381
+00:35:00,020 --> 00:35:04,260
+التيسيرة، في الشرق والدين اللي عايش، كل ما ضاقت
+
+382
+00:35:04,260 --> 00:35:10,720
+انفرجت، والله أنا مريض، كنت تصلي، مطلوب منك تقوم، تصوم
+
+383
+00:35:10,720 --> 00:35:16,380
+تقوم، تقعد، كنت كذا، تعمل كذا، كل ما هناك مشاقة من فضل
+
+384
+00:35:16,380 --> 00:35:23,500
+الله علينا جعلها تيسير، والشك لا يُحكم به متيقناً،
+
+385
+00:35:23,500 --> 00:35:31,250
+يعني اليقين يغلب الشك، ماشي، فإذا أنا والله
+
+386
+00:35:31,250 --> 00:35:37,710
+اتوضيت،
+
+445
+00:41:04,640 --> 00:41:08,840
+الثالثة Avoidance of Maleficence اللي هو يعني
+
+446
+00:41:08,840 --> 00:41:12,680
+دايما بيقولوا القاعدة الأولى في الطب First of all
+
+447
+00:41:12,680 --> 00:41:17,600
+do no harm باللغة الإنجليزية، القانون الأول في الطب
+
+448
+00:41:17,600 --> 00:41:24,480
+لا يعني do no harm أي من حتى اللاتينية Primum Non
+
+449
+00:41:24,480 --> 00:41:30,020
+-Nucrilic نوسريلي اللي هي ذلك، الله أعلم، يعني من
+
+450
+00:41:30,020 --> 00:41:34,520
+اللغة اللاتينية من «abocrat» وهي إنه لا تؤذي
+
+451
+00:41:34,520 --> 00:41:37,220
+الإنسان، إذا ما قدرتش تفيده على الأقل أنت ما
+
+452
+00:41:37,220 --> 00:41:43,920
+تتضرّشه، ماشي؟ إذا شاء يعني يعمل أو تدبّر إن هذا يسبب
+
+453
+00:41:43,920 --> 00:41:48,740
+ضرر، يسبب مرض، وإذا عملت كذا راح يكون فيه مشكلة
+
+454
+00:41:48,740 --> 00:41:53,300
+المفروض إنك أنت ما تسويها. الأمر الأخير، أو القاعدة
+
+455
+00:41:53,300 --> 00:41:57,950
+الأخيرة هي قضية العدالة «justice»، ensuring that all
+
+456
+00:41:57,950 --> 00:42:01,550
+individuals are treated equally and fairly. هذه
+
+457
+00:42:01,550 --> 00:42:05,730
+مبادئ إسلامية. يعني الرسول صلى الله عليه وسلم عندما
+
+458
+00:42:05,730 --> 00:42:12,050
+يعني يقول: إنما أهلك من كان قبلكم كان إذا سرق
+
+459
+00:42:12,050 --> 00:42:16,570
+الشريف فيهم تركوه، وإذا سرق فيهم الضعيف أقاموا عليه
+
+460
+00:42:16,570 --> 00:42:22,590
+الحد. عندهم خيار وفقوس، ويعني الناس أنواع ودرجات
+
+461
+00:42:22,590 --> 00:42:27,830
+وهذه يعني عيب في أي مجتمع. المفروض تكون يعني مبدأ
+
+462
+00:42:27,830 --> 00:42:34,670
+العدالة. يعني أنا مثلاً، مرات كثيرة تصدف الواحد يجي
+
+463
+00:42:34,670 --> 00:42:40,330
+مرضى. طبعاً هذه القضايا الأخلاقية بدّ الواحد ياخد
+
+464
+00:42:40,330 --> 00:42:46,170
+مجمل القواعد كلها ويطبق عليها، وهنشوف أنّه لأ، أن
+
+465
+00:42:46,170 --> 00:42:50,510
+أحياناً القاعدتين بتضاربو، وبالتالي بدّ الواحد يحكم
+
+466
+00:42:50,510 --> 00:42:57,070
+بينهم، وربنا يهديه إلى القرار الأفضل. العدالة شغل
+
+467
+00:42:57,070 --> 00:43:06,110
+مطلوبة. يعني مثلاً كان عندنا يكون مشكلة أن أنت تطالب
+
+468
+00:43:06,110 --> 00:43:10,350
+بتقرير: هل هي حالة طارئة ولا مش طارئة؟ كنا لشغل
+
+469
+00:43:10,350 --> 00:43:15,230
+التأمين، ما تأميني. يضطروا نروح على المريض اللي داخل
+
+470
+00:43:15,230 --> 00:43:18,750
+على التأمين في مستشفى خاص، المفروض ما راح عليه
+
+471
+00:43:18,750 --> 00:43:25,250
+مريض، شو اسمه؟ نروح نشوف، والله قالوا لي كانوا
+
+472
+00:43:25,250 --> 00:43:29,790
+بالأول يقولوا لي: إذا الإنسان ما كان بدّه يموت، وفعلاً
+
+473
+00:43:29,790 --> 00:43:37,210
+يعني فعلاً، خالص خالص، هاي كان ممكن يروح على مستشفى
+
+474
+00:43:37,210 --> 00:43:43,240
+الحكومي، وبالتالي هي مش طارئة. فنروح، وفعلاً كنت أطبق
+
+475
+00:43:43,240 --> 00:43:48,000
+هذا الموضوع. لو كان واحد جاي بتجلطة أو حادث سير و
+
+476
+00:43:48,000 --> 00:43:53,700
+بيجيبوا على الفور في مستشفى، وكان مستشفى خاص فخلاص
+
+477
+00:43:53,700 --> 00:43:59,380
+هي طارئة. لما واحد عنده مثلاً حمّة صار لها أسبوع ومتعبان
+
+478
+00:43:59,380 --> 00:44:03,020
+ومتعب كتير، واخذوه على، يعني كان عندهم قرار يعني
+
+479
+00:44:03,020 --> 00:44:07,180
+مجال يودّوه على المستشفى، كنت بقول هي مش طارئة لحد ما
+
+480
+00:44:07,180 --> 00:44:14,740
+يوم من الأيام، بيجيني، الله يرضى عليه، كان وزير سابقاً
+
+481
+00:44:14,740 --> 00:44:21,580
+يعني، وكانت والدته، فقال لي: يا دكتور أنا هاي والدتي
+
+482
+00:44:21,580 --> 00:44:26,500
+وهي مريضة درجة أولى، وطبعاً والدة وزير، وأنا بدّي
+
+483
+00:44:26,500 --> 00:44:30,380
+أدخّلها بالمكان اللي فلان عاجبك عاجبك، ما عجبك مش
+
+484
+00:44:30,380 --> 00:44:35,420
+ما عجبك نوصلّها للملك ونمشيها غصب عنها. فاتصلت في
+
+485
+00:44:35,420 --> 00:44:38,920
+المسؤول عني، بقول له: هيك هيك هيك، الزلمة هذا بيحكي، قال
+
+486
+00:44:38,920 --> 00:44:43,800
+يا عمي ما هو وزير، هاي أمه، خلاص، مشّيها يعني مش
+
+487
+00:44:43,800 --> 00:44:48,260
+طارئة، مش طارئة، مشّيها. كنت حاضر، همشّيها، بس والله
+
+488
+00:44:48,260 --> 00:44:52,520
+بعد ذلك، كل إنسان عنده إشي بيقول: تقول لي طارئة ولا
+
+489
+00:44:52,520 --> 00:44:55,280
+مش طارئة، مدام هي طلعت وراحت على الطوارئ، هقول لكم
+
+490
+00:44:55,280 --> 00:44:59,940
+إنّه طارئة، فصرت أمشّي كل الناس طارئة، لأنه بحب أعمل
+
+491
+00:44:59,940 --> 00:45:05,160
+الناس بعدالة، لكل الناس عندي سواسية، ما فيه تفضيل
+
+492
+00:45:05,160 --> 00:45:13,370
+أو تَبْكير. فهذه المبادئ الأساسية، الـ هناك يعني بالذات
+
+493
+00:45:13,370 --> 00:45:20,430
+أمور الوراثة، مبادئ يعني أو نقاط معينة واضحة ضمن
+
+494
+00:45:20,430 --> 00:45:28,190
+المبادئ اللي حكيناها. يعني هل يعني يوافق عليها
+
+495
+00:45:28,190 --> 00:45:33,110
+الواحد ولا لا يوافق؟ فمثلاً الـ prenatal diagnosis
+
+496
+00:45:33,110 --> 00:45:40,300
+مثلاً قضية الـ non-disease traits أو sex مثلاً. يعني
+
+497
+00:45:40,300 --> 00:45:43,840
+مثلاً من المشهور، معروف، يقول: كيف عيب الدنيا بتتخربط
+
+498
+00:45:43,840 --> 00:45:50,740
+مثلاً في الهند، في نقص شديد في النساء، بسبب إيش؟
+
+499
+00:45:50,740 --> 00:45:54,260
+بالموجات فوق الصوتية، من أول ما يبين الأعضاء التناسلية، وإذا
+
+500
+00:45:54,260 --> 00:45:58,780
+أنتِ بتكتشفيها يعني، وإذا هي مؤنّثة تسوّي لها إيش؟ هي دي
+
+501
+00:45:58,780 --> 00:46:03,080
+المؤنّثة، ماشي؟ يصير الواحد مثلاً يشوف: إذا بالذات
+
+502
+00:46:03,080 --> 00:46:07,770
+إذا الشغل مش مرض. يعني أنا بدّي ابني يطلع طويل، إذا
+
+503
+00:46:07,770 --> 00:46:11,630
+والله طلع قصير، وإيش قدرت أدرسها، إذا عرفت الـGene
+
+504
+00:46:11,630 --> 00:46:15,010
+على طول بقى مسؤول عن الطول، إذا واحد اللي قصير
+
+505
+00:46:15,010 --> 00:46:20,470
+بدّه يطوّل بيصير واحد يعني يتخذ إجراءات معينة.
+
+506
+00:46:20,470 --> 00:46:24,730
+Testing of asymptomatic adults for genotypes that
+
+507
+00:46:24,730 --> 00:46:29,250
+predispose to late onset diseases. يعني هل هذا جائز
+
+508
+00:46:29,250 --> 00:46:32,910
+مش جائز؟ Testing asymptomatic children for
+
+509
+00:46:32,910 --> 00:46:36,550
+genotypes that predispose to adult-onset diseases.
+
+510
+00:46:36,550 --> 00:46:41,470
+يعني بالذات إنت لما تعمل الفحص هذا،  العيش بده كِثار
+
+511
+00:46:41,910 --> 00:46:46,610
+ممكن أنا أبحث فيه، ممكن واحد من نتائج الدراسات يكون
+
+512
+00:46:46,610 --> 00:46:52,070
+عنده معلومة معينة. Secondary
+
+513
+00:46:52,070 --> 00:46:55,410
+findings and the right to not to know about
+
+514
+00:46:55,410 --> 00:46:59,230
+clearly deleterious mutations that will cause
+
+515
+00:46:59,230 --> 00:47:03,330
+disease that could be ameliorated or prevented if
+
+516
+00:47:03,330 --> 00:47:08,890
+the risks were known. يعني أحياناً يعني في أشياء
+
+517
+00:47:09,530 --> 00:47:16,150
+يمكن تطلع بشكل ثانوي، بس يعني هل حق الإنسان يعرفها؟
+
+518
+00:47:16,150 --> 00:47:22,850
+هل واجب علينا نبلغه؟ هل مرات بتكون الأمور مُشتبهة؟
+
+519
+00:47:22,850 --> 00:47:29,050
+Privacy of genetic information. يعني قضية سرية
+
+520
+00:47:29,050 --> 00:47:36,290
+المعلومات. سرية المعلومات من النواحي المهمة في الـ
+
+521
+00:47:36,290 --> 00:47:45,810
+Chats نحكي
+
+522
+00:47:45,810 --> 00:47:51,490
+بالآخر قضية
+
+523
+00:47:51,490 --> 00:48:01,710
+إنّه إذا سويت تجربة، هل الموضوع علني ولا سري؟ يعني
+
+524
+00:48:01,710 --> 00:48:06,570
+مثلاً حكينا اللي راح نحكي، مثلاً بالآخر الـGenetic
+
+525
+00:48:06,570 --> 00:48:14,160
+Screening، من قضية برضه فيها Privacy. يعني إذا أنا
+
+526
+00:48:14,160 --> 00:48:21,800
+والله عملت Screen وطلع إنسان إيجابي، ممكن هناك مثلاً
+
+527
+00:48:21,800 --> 00:48:26,940
+ناس بيرغبوا في أن حد يعرف عنهم، في مثلاً قد تكون نوع
+
+528
+00:48:26,940 --> 00:48:34,060
+من سبب الخجل، سبب التأثر، قلق، وإحنا مطلوب كدكتور
+
+529
+00:48:34,060 --> 00:48:39,860
+إنّه نخفّف قلق أي إنسان. يعني هذا واجب لجميع المرضى
+
+530
+00:48:39,860 --> 00:48:47,980
+ماشي؟ إلا الأمور فيها خطر على صحة المجتمع، أو مرض
+
+531
+00:48:47,980 --> 00:48:53,040
+معدٍ، وإذا أنا ما حجرت هذا الإنسان وما عمّمت على
+
+532
+00:48:53,040 --> 00:48:57,660
+إنّه هذا مصاب لفترة معينة، أنا منع أن أتعامل معه، أنا
+
+533
+00:48:57,660 --> 00:49:01,880
+أسّس زي الـ COVID. هذا مشكلة، إذا الواحد يقول: كل واحد
+
+534
+00:49:01,880 --> 00:49:06,420
+أنا حقي أنا أسري معلومتي، إذا أنا إيجابي إنك ما
+
+535
+00:49:06,420 --> 00:49:11,870
+تبلغ، وما تخلي حد يعرف، ويضل الواحد يشتم زي ما بدّه
+
+536
+00:49:11,870 --> 00:49:15,890
+ناشي؟ فالـ Privacy of genetic information أو
+
+537
+00:49:15,890 --> 00:49:19,490
+medical information. Misuse of genetic information
+
+538
+00:49:19,490 --> 00:49:26,430
+يعني هذه أهم شيء. مثلاً مرات في خيارات مثلاً جوانب
+
+539
+00:49:26,430 --> 00:49:32,870
+زي التأمين، مثلاً توظيف كذا. يعني إحنا في أمريكا
+
+540
+00:49:32,870 --> 00:49:36,210
+المساواة بين الأعراق، من المبادئ اللي عندهم مشكلة
+
+541
+00:49:36,210 --> 00:49:42,380
+فيها. والله أنا بعلم للتوضيح، لون الإنسان هو شغل
+
+542
+00:49:42,380 --> 00:49:48,920
+واضح، وأنا آسف، يجيني أبيض أو يجيني أسود ما أضيقش
+
+543
+00:49:48,920 --> 00:49:54,520
+خصوصاً إذا كان من الحكومة، أو من الأشياء، مش المؤسسات
+
+544
+00:49:54,520 --> 00:50:00,050
+الخاصة، الخاصة. إذا بالذات يعني زي ما تقول شخصية، أنا
+
+545
+00:50:00,050 --> 00:50:08,110
+والله حرّ، والله إنسان يعني أسمر اللون وكذا، بعتبره
+
+546
+00:50:08,110 --> 00:50:14,710
+مرعب، بعتبره يعني عندي حق، يعني هذا مالي وأنا صاحب
+
+547
+00:50:14,710 --> 00:50:20,510
+المؤسسة، وأنا حر. بتكون مؤسسات عامة، بتكون حكومية،
+
+548
+00:50:20,510 --> 00:50:27,770
+بتكون كذا، لأ، الأصل تكون النسب متساوي. يعني عشرة
+
+549
+00:50:27,770 --> 00:50:32,770
+بالمئة من الـ population سود أو فَرقاء، إذا عشرة
+
+550
+00:50:32,770 --> 00:50:36,310
+بالمئة من الشرطة لازم تكون سود، عشرة بالمئة
+
+551
+00:50:36,310 --> 00:50:41,250
+من موظفي الحكومة لازم تكون سود، ما بيصير مثلاً كلهم
+
+552
+00:50:41,250 --> 00:50:45,310
+يكونوا بيض، ما يكونش ولا واحد أسود، يعني فإيش قضية
+
+553
+00:50:45,310 --> 00:50:50,070
+التأمين، قضية التوظيف، قضية الحقوق والتعامل مع
+
+554
+00:50:50,070 --> 00:50:56,840
+الناس كلها فيها مشاكل أخلاقية، ويليها. يعني مبادئ
+
+555
+00:50:56,840 --> 00:51:02,560
+أخلاقية يجب أن ينتبه لها الواحد. فيعني هدول يعني
+
+556
+00:51:02,560 --> 00:51:10,500
+كأمثلة، من ضمن الأشياء اللي قد تكون هنا، آخر الـ
+
+557
+00:51:10,500 --> 00:51:21,700
+slide حاطينه على إنه قصة امرأة شو اسمه، عمرها الآن
+
+558
+00:51:21,700 --> 00:51:25,930
+أربعين سنة، عندها طلع بيّن Autosomal Dominant
+
+559
+00:51:25,930 --> 00:51:30,130
+Disorder. يعني اللي حكيناها، مثلاً زي Alzheimer، آسف
+
+560
+00:51:30,130 --> 00:51:34,050
+اللي هو Huntington's Chorea. هذا مرض والله سيء
+
+561
+00:51:34,050 --> 00:51:38,990
+وبيقتل الإنسان بالأخير، بس بيظهر وبيبدأ على عمر متأخر
+
+562
+00:51:38,990 --> 00:51:45,830
+فصدفة إنّه اكتشفنا المرض عند هذه السيدة
+
+563
+00:51:45,830 --> 00:51:51,930
+ولقينا عندها mutation معيّن. عندها بنت من زوجها
+
+564
+00:51:51,930 --> 00:51:57,980
+الأول، والبنت كمان عندها. كأنّه هاي الـ mutation
+
+565
+00:51:57,980 --> 00:52:06,760
+وعرفت عندها ابن أو أخ غير شقيق من رجل آخر بعد طلاق
+
+566
+00:52:06,760 --> 00:52:11,520
+الزوجين الأولين. المرأة هاي اللي عمرها الآن أربعين
+
+567
+00:52:11,520 --> 00:52:18,540
+تزوجت زلمة ثانية وجابت منه طفل، ولد. فالبنت والأم
+
+568
+00:52:19,390 --> 00:52:24,530
+عندهم الـ Genetic Mutation لـ Autosomal Dominant
+
+569
+00:52:24,530 --> 00:52:29,730
+وهي Serious وبتبين على عمر صغير. هل واجب أن نبحث
+
+570
+00:52:29,730 --> 00:52:35,170
+أخوهم؟ اللي هو يعني الغير شقيق للأخت، للبنت هذه
+
+571
+00:52:35,170 --> 00:52:40,270
+المصابة. هل يجب أن نخبره عن هذا الموضوع ولا لأ؟
+
+572
+00:52:40,270 --> 00:52:45,510
+نتركه وما نقول لهوش ولا كده؟ يعني إذا الواحد بيقرأ
+
+573
+00:52:45,510 --> 00:52:54,380
+هذا السيناريو، مثلاً، هل يجب أن نبلغه ولا ما نبلغوش؟
+
+574
+00:52:54,380 --> 00:52:59,260
+هو أنا بشرح طريقة تفكير المؤلفين، إنّه فيه أول شي
+
+575
+00:52:59,260 --> 00:53:09,440
+Clinical Question، يعني القرار. يعني في الفقه هناك
+
+576
+00:53:09,440 --> 00:53:17,920
+قاعدة بتقول: الحكم
+
+577
+00:53:17,920 --> 00:53:26,040
+على الشيء فرع من فهمه لهذا الشيء. يعني عشان هيك
+
+578
+00:53:26,040 --> 00:53:29,580
+كان فيه كثير من القضايا الطبية، بالذات اللي كانت
+
+579
+00:53:29,580 --> 00:53:36,120
+فيها جوانب أخلاقية، قانونية، كده نجد القضاء وفقهاء
+
+580
+00:53:36,120 --> 00:53:40,840
+الشرع الحنيف بيقول لك، بيعملوا اجتماعات معنى كأطباء
+
+581
+00:53:40,840 --> 00:53:47,600
+عشان يسألونا شو معنى كده، شو معنى كده، والله. بالذات
+
+582
+00:53:47,600 --> 00:53:51,800
+يعني، يعني بالذات في جوانب الأخلاقية، إذا بننتبه
+
+583
+00:53:51,800 --> 00:53:58,220
+الواحد. نقطتين: بداية الحياة ونهاية الحياة، هدول
+
+584
+00:53:58,220 --> 00:54:03,800
+بتلاقي عليهم جدال أخلاقي كبير. إذا مثلاً هولندا
+
+585
+00:54:03,800 --> 00:54:10,520
+لإنسان طبيعي، مش مكتئب، مش عنده depression، يقول لك
+
+586
+00:54:10,520 --> 00:54:15,270
+والله أنا عندي سرطان أو عندي مرض لا يُرجى شفاؤه،
+
+587
+00:54:15,270 --> 00:54:19,090
+يا دكتور في عيد ميلادي الجاي، اقضي عليّ، واعطيني حقنة
+
+588
+00:54:19,090 --> 00:54:26,610
+أموت وأخلص، وأحرّق جسمي وخلاص، ملّيت من هذا التوتر
+
+589
+00:54:26,610 --> 00:54:32,810
+والقلق وكذا. فيه في هولندا هذا بيحصلوا، مقبول شرعياً
+
+590
+00:54:32,810 --> 00:54:36,470
+وأخلاقياً
+
+591
+00:54:36,470 --> 00:54:40,290
+ومجتمعياً، يعني فيه غالبية أو ناس كبيرة بتقبل هذا
+
+592
+00:54:40,290 --> 00:54:45,200
+الأشياء. بتلاقيهم كلهم، بتلاقي اللي والله أنا بعد
+
+593
+00:54:45,200 --> 00:54:51,400
+الشهرين أنا متّفق مع الدكتور يخلص عليّ، ومدام أنا مش
+
+594
+00:54:51,400 --> 00:54:58,440
+مُبتَعب، وبالقانون، بيصير يعني، باعطي الدكتور الحقنة
+
+595
+00:54:58,440 --> 00:55:06,840
+القاتلة، والإنسان هذا بيكمل. فالسيناريو هذا يعني
+
+596
+00:55:06,840 --> 00:55:15,860
+بيؤكد على، أولاً، إنّه إحنا يجب علينا يعني، نتعامل مع
+
+597
+00:55:15,860 --> 00:55:21,720
+هذا الجانب، ويريد أن يعطي حكماً أخلاقياً، وانتباه
+
+598
+00:55:21,720 --> 00:55:27,240
+لهذا الجانب. أول شيء يجب أن يكون فهماً تماماً جوانب
+
+599
+00:55:27,240 --> 00:55:31,740
+الطبية، الصحية، العلمية من هذه الحالة. قضية
+
+600
+00:55:31,740 --> 00:55:35,220
+Penetrance of the Disorder. يعني هل هناك احتمالية
+
+601
+00:55:35,220 --> 00:55:40,020
+أن هذا الفحص صحيح؟ قال إنّه في اشتباه بيصير هذه
+
+602
+00:55:40,020 --> 00:55:47,140
+الحالة. بس هل هي متأكدة؟ ما فيش احتمالي إن الفحص هذا
+
+603
+00:55:47,140 --> 00:55:55,480
+مش بالقوّة؟ هل هو lethal؟ هل هي كذا؟ طبعاً بيرجع
+
+604
+00:55:55,480 --> 00:55:59,820
+الأمر حسب القانون. يعني في دول كتيرة القانون بيقول لك
+
+605
+00:55:59,820 --> 00:56:05,460
+الإجهاض حرام، ولا تستطيع يعني، يعني يعاقب الطبيب
+
+606
+00:56:05,460 --> 00:56:09,860
+النسائي اللي ما بيسوي الإجهاض. مثلاً السبب إنّه
+
+607
+00:56:09,860 --> 00:56:14,380
+بيقول لك: إذا المرأة هذه إن هي مقررة وهذا جزء من جسمها
+
+608
+00:56:14,380 --> 00:56:18,680
+مقررة بدّها تخلص منه، إذا أنت ما سويت لها يا طبيب
+
+609
+00:56:18,680 --> 00:56:23,340
+الإجهاض بطريقة سليمة علمياً أو طبياً أو صحياً
+
+610
+00:56:23,340 --> 00:56:28,220
+بتروح تسويها عند إنسان غير متخصص، وما فيش نِبْاطي
+
+611
+00:56:28,220 --> 00:56:32,660
+وما فيش كذا، وبتتوفّى لأنها سوّت الإجهاض بطريقة غير
+
+612
+00:56:
+
+667
+01:02:26,490 --> 01:02:33,150
+منهم لما نسوي الـ Population Screen راح يكون أو
+
+668
+01:02:33,150 --> 01:02:40,610
+افترضنا إنه الـ HIV واحد بالمائة ألف فالنتيجة كل
+
+669
+01:02:40,610 --> 01:02:49,670
+مليون فيهم عشرة، وعندي عشر ملايين، بلاش 100 مليون،
+
+670
+01:02:49,670 --> 01:02:53,790
+واحد بالـ100 ألف، خَلّي الـHIV واحد بالعشرة آلاف،
+
+671
+01:02:53,790 --> 01:02:57,590
+نفترض أظن أنه أقرب لواحد بالـ100 ألف، بس افتراضًا
+
+672
+01:02:57,590 --> 01:03:02,190
+نفترض أنه واحد بالمليون، واحد بالعشرة آلاف فكل
+
+673
+01:03:02,190 --> 01:03:06,010
+مليون فيهم مئة، وعشر ملايين يعني بيطلعوا عشرة آلاف
+
+674
+01:03:06,010 --> 01:03:10,510
+بني آدم أنا راح أصيد العشرة آلاف بني آدم، العشرة
+
+675
+01:03:10,510 --> 01:03:16,340
+آلاف راح يكونوا تسعمئة وتسعون ألفًا وتسعمئة وتسعون
+
+676
+01:03:16,340 --> 01:03:20,900
+واحد راح أصيبهم، وعشرة ملايين مش راح أصيبهم
+
+677
+01:03:20,900 --> 01:03:27,680
+فأنا لقيت تسعمئة وتسعون ألفًا وتسعمئة وتسعة و تسعون واحد عندهم
+
+678
+01:03:27,680 --> 01:03:32,800
+المرض بالفعل، بس شو اللي راح يصير؟ لأن أنا أعمل فحص
+
+679
+01:03:32,800 --> 01:03:39,780
+لكل الناس، أنا لازم أفحص عشر ملايين، العشر ملايين
+
+680
+01:03:40,620 --> 01:03:44,000
+التسعة ملايين يعني الغالبية العظمى منهم ما عندهمش تقريبًا
+
+681
+01:03:44,000 --> 01:03:48,500
+عشر ملايين يعني غير العشرة آلاف، البقية التسعة
+
+682
+01:03:48,500 --> 01:03:54,580
+ملايين، التسعمئة وتسعون ألفًا ما عندهمش المرض، فلما
+
+683
+01:03:54,580 --> 01:03:58,940
+يكون الـ specificity برضه تسعة وتسعون بالمئة
+
+684
+01:03:58,940 --> 01:04:06,000
+النتيجة إنه واحد بالمئة من التسعة ملايين راح يطلع
+
+685
+01:04:06,000 --> 01:04:15,140
+حوالي، تقريبًا بقدر مثلًا 1% من 9، 10 ملايين تقريبًا
+
+686
+01:04:15,140 --> 01:04:24,760
+راح يطلعوا تقريبًا، شو اسمه؟ مئة ألف ماشي، 1% من 10
+
+687
+01:04:24,760 --> 01:04:31,760
+ملايين كم بتطلع؟ هيك يحفظوه تقريبًا مئة
+
+688
+01:04:31,760 --> 01:04:39,010
+ألف، واحد بالمئة من المليون في عشرة آلاف في
+
+689
+01:04:39,010 --> 01:04:45,630
+عشرة راح يطلع مئة ألف واحد صحيح، صح راح يطلع إنه
+
+690
+01:04:45,630 --> 01:04:50,150
+إيجابي من الـ Negative False Positive يعني هو من
+
+691
+01:04:50,150 --> 01:04:52,890
+الـ Negative بالأصل بس راح يطلع False Positive
+
+692
+01:04:52,890 --> 01:04:58,610
+راح يطلع بحدود مئة ألف واحد، فشو النتيجة صارت؟
+
+693
+01:04:58,610 --> 01:05:03,920
+إنه لما يطلع عندك Test Positive حقيقةً عشرة بالمئة
+
+694
+01:05:03,920 --> 01:05:08,520
+بس من الـ positives هم الـ true positives، وتسعون
+
+695
+01:05:08,520 --> 01:05:12,160
+بالمئة من الـ positives هم كانوا false positives
+
+696
+01:05:12,160 --> 01:05:15,920
+يعني هم negative، فأنا في الحالة هذه ما استفدت من
+
+697
+01:05:15,920 --> 01:05:22,880
+الفحص، ما بيصير، ما بيصيرش أسويها، ليش؟ لأن الفحص
+
+698
+01:05:22,880 --> 01:05:28,000
+هذا أنا بسويه في مجموعة احتمالية وجود المرض قليلة
+
+699
+01:05:28,000 --> 01:05:35,320
+جدا، وبالتالي أنا وبالتالي راح يكون الاستفادة منه مش
+
+700
+01:05:35,320 --> 01:05:42,020
+كتيرة، واضح؟ بينما لو جبت هذا الـ Test، وروحت مثلًا
+
+701
+01:05:42,020 --> 01:05:48,400
+على سجن، قلنا السجن فيه ناس مدمنين مخدرات، فيه ناس
+
+702
+01:05:48,400 --> 01:05:54,560
+بيدمنوا الحقن (IV Drug Abuse)، فيه ناس عندهم سلوكيات جنسية
+
+703
+01:05:54,560 --> 01:06:03,520
+غير سوية مثلًا، ماشي، والـ HIV نسبته بتوقع أنها
+
+704
+01:06:03,520 --> 01:06:07,480
+أعلى، أو أنا ممكن أكون درست وشفت أنه عندهم نسبة
+
+705
+01:06:07,480 --> 01:06:13,520
+أعلى، باستخدام هذا الفحص بيصير في هذه المجموعة كـ
+
+706
+01:06:13,520 --> 01:06:19,920
+Diagnostic Testing اللي… اللي شو اسمه؟ اللي لما
+
+707
+01:06:19,920 --> 01:06:22,760
+يكون Positive بيكون فعلاً Positive، لما يكون
+
+708
+01:06:22,760 --> 01:06:27,720
+Negative فعلاً بيكون Negative، فاهم عليك كده؟ فهنا
+
+709
+01:06:27,720 --> 01:06:31,690
+أنت الـ test مرة استخدمته كـ Screening للـ
+
+710
+01:06:31,690 --> 01:06:37,810
+population، والنتيجة راح تكون إنه أنت يعني ما راح
+
+711
+01:06:37,810 --> 01:06:43,730
+تستفيد، فاهم عليك كده؟ أما إذا استخدمته كـ Diagnostic
+
+712
+01:06:43,730 --> 01:06:47,570
+Testing، يعني شوف هنا، اقرأ معاه الـ Clinical
+
+713
+01:06:47,570 --> 01:06:53,350
+Validity، في الحالة الأولى أنا جيت، شو سويت؟ جبت الـ
+
+714
+01:06:53,350 --> 01:06:58,050
+population وكل الـ Asymptomatic Individuals، Age 65
+
+715
+01:06:58,050 --> 01:07:04,650
+لـ 74، جيت على مجتمع كل البني آدمين اللي من عمره 65
+
+716
+01:07:04,650 --> 01:07:11,430
+لـ 74، جيت وهم ما عندهم، ما بعرف، جيت فحصتهم أنا
+
+717
+01:07:11,430 --> 01:07:15,090
+بعرف الـ Population Prevalence of this condition
+
+718
+01:07:15,090 --> 01:07:21,410
+اللي هو Alzheimer Disease 3000%، شايف عليا؟ اللي
+
+719
+01:07:21,410 --> 01:07:27,010
+لما تشوف الـ Test اللي أنت، مع إنه كويس، هو بالأخير
+
+720
+01:07:27,010 --> 01:07:32,750
+مالوش قيمة، الـ Positive Predictive Value لو هذه 6%
+
+721
+01:07:32,750 --> 01:07:38,150
+الـ Positive Predictive Value لـ 23% يعني أنت
+
+722
+01:07:38,150 --> 01:07:43,930
+حتى الـ 23% معناته 77% من اللي راح يطلعوا Positive
+
+723
+01:07:43,930 --> 01:07:50,050
+هم False Positive، هم Negative بالأصل، ماشي؟
+
+724
+01:07:50,050 --> 01:07:56,030
+و الملاحظة الثالثة كمان، إنه لهذه الحالة، و لهذه
+
+725
+01:07:56,030 --> 01:08:01,600
+المرض ما فيش إيش تسوي له، فيش إيش تسوي، تقول ماشي، بفحص
+
+726
+01:08:01,600 --> 01:08:06,740
+بظل بهمني يعني الـ Phenylketonuria ما هو under من
+
+727
+01:08:06,740 --> 01:08:11,880
+3%، أقل من 3%، مع ذلك بنسويه، لأنه فيش إيش تسوي، بس
+
+728
+01:08:11,880 --> 01:08:18,240
+هنا ما فيش يعني intervention أو علاج تقدر تسويه، شو
+
+729
+01:08:18,240 --> 01:08:22,220
+راح تسبب؟ أنت راح تعمل psychological stress for
+
+730
+01:08:22,220 --> 01:08:26,700
+most people، يعني كثير ناس هيطلع false positive و
+
+731
+01:08:26,700 --> 01:08:30,970
+Negative و False Positive وبالتالي راح تسوي له قلق
+
+732
+01:08:30,970 --> 01:08:37,570
+و اللي مرات عنده الـ Negative، يطلع مرتاح و ب… ب…
+
+733
+01:08:37,570 --> 01:08:41,030
+ب… يعني ب… ب… ب… بيفرح، وأنا والله طلعت
+
+734
+01:08:41,030 --> 01:08:44,150
+Negative مش راح يصيبني هذا، وأنت بتعطيه False
+
+735
+01:08:44,150 --> 01:08:50,530
+Reaction، لأنه ممكن يكون غلط، وإنما لو أنا جيت مثال
+
+736
+01:08:50,530 --> 01:08:57,770
+آخر، أخدت اللي أعمارهم برضه 65 لـ 74 بس عنده أعراض الـ
+
+737
+01:08:57,770 --> 01:09:02,630
+dimension، هدول مجموعة ناس أجوا اشتكوا، والله أنا
+
+738
+01:09:02,630 --> 01:09:06,390
+بنسى، والله أنا بحط الـ issue وبعدين بنسى وين
+
+739
+01:09:06,390 --> 01:09:11,590
+حطيته، طلعت على السوق، وبعدين ما عرفتش أرجع بيتي
+
+740
+01:09:11,590 --> 01:09:16,730
+والله أنا كذا، يعني ناس عندهم مشكلة، ماشي واضح يا
+
+741
+01:09:16,730 --> 01:09:17,190
+كريم؟
+
+742
+01:09:19,940 --> 01:09:23,880
+- يا عزيزي، يا عزيزي، يا عزيزي، يا عزيزي، يا
+
+743
+01:09:23,880 --> 01:09:24,100
+عزيزي، يا عزيزي، يا عزيزي، يا عزيزي، يا عزيزي، يا
+
+744
+01:09:24,100 --> 01:09:27,360
+عزيزي، يا عزيزي، يا عزيزي، يا عزيزي، يا عزيزي، يا
+
+745
+01:09:27,360 --> 01:09:31,180
+عزيزي، يا عزيزي، يا عزيزي، يا عزيزي، يا عزيزي، يا
+
+746
+01:09:31,180 --> 01:09:35,400
+عزيزي، يا عزيزي، يا عزيزي، يا عزيزي، يا عزيزي، يا
+
+747
+01:09:35,400 --> 01:09:41,640
+عزيزي، يا عزيزي، يا عزيزي، يا عزيزي، يا عزيزي، يا
+
+748
+01:09:41,640 --> 01:09:49,930
+عزيزي، يا عزيزي، يا عزيزي، يطلع عندهم ثلاثة حقيقيين
+
+749
+01:09:49,930 --> 01:09:54,210
+واحد بس كاذب، أو إذا الـ Combination الثانية أنت
+
+750
+01:09:54,210 --> 01:10:00,950
+بتوصل 98%، يعني من خمسين بني آدم تسعة وأربعون
+
+751
+01:10:00,950 --> 01:10:06,990
+بيكونوا حقيقيين، فالفائدة تبع الـ Test بهذه الطريقة
+
+752
+01:10:06,990 --> 01:10:13,310
+بتكون الفائدة لهذا الـ Test في هذه الطريقة إيش؟ إنه لو
+
+753
+01:10:13,310 --> 01:10:21,910
+كان إنسان عنده… عنده dementia حقيقية وبداية
+
+754
+01:10:21,910 --> 01:10:27,110
+أعراض، والـ Test طالع Negative، فأروح أدور على شيء
+
+755
+01:10:27,110 --> 01:10:30,490
+ثاني، هذا مش الـ Alzheimer اللي أنا ما أقدرش أتوَقّعه
+
+756
+01:10:30,490 --> 01:10:35,630
+شيء لأ، هذا مثلًا عنده الغدة الدرقية مضروبة، والله
+
+757
+01:10:35,630 --> 01:10:42,390
+عنده نقص تروية من شرايين الدماغ، عنده سبب آخر للـ
+
+758
+01:10:42,390 --> 01:10:47,190
+dementia، فبالتالي لما نكون حاليًا بهذه الطريقة
+
+759
+01:10:47,190 --> 01:10:52,870
+بيصير عندي Suspicion that other potentially
+
+760
+01:10:52,870 --> 01:10:57,150
+treatable cause، بيكون، لو عنده Hypothyroidism
+
+761
+01:10:57,150 --> 01:11:00,750
+بيعطيه Thyroxine بيحسّنه، بتروح، بيصير كويس، بتروح
+
+762
+01:11:00,750 --> 01:11:06,050
+هاي الشغل منه، واحد عنده مرض نفسي، اكتئاب، كذا،
+
+763
+01:11:06,050 --> 01:11:09,960
+بيعطيه دواء، بتحسن، بتروح، فأنت هنا بتصير تدور على
+
+764
+01:11:09,960 --> 01:11:14,120
+شيء ثاني، لأنك إذا قلت إنه high Alzheimer خلاص،
+
+765
+01:11:14,120 --> 01:11:17,600
+ما بتقدرش تسوي له شيء، و produces unnecessary
+
+766
+01:11:17,600 --> 01:11:25,700
+testing، فهذه الأهمية، إنه الفحص، ولو إن الاتنين 99%
+
+767
+01:11:25,700 --> 01:11:32,200
+sensitive و specific، شو أهميته؟ وين تبقى بسويها؟
+
+768
+01:11:32,200 --> 01:11:35,400
+ففيه Clinical Validity و Clinical Utility، يعني
+
+769
+01:11:36,300 --> 01:11:40,700
+استفادة، ومن وين هو valid، يعني الـ test هذا للـ
+
+770
+01:11:40,700 --> 01:11:44,220
+population screening غلط، ما بيصير أسويه، مش يقول
+
+771
+01:11:44,220 --> 01:11:47,140
+أنا عندي الـ test، يلّا كل واحد عنده، خلاص بعمله
+
+772
+01:11:47,140 --> 01:11:51,860
+يا وصير أخبص، فاهم عليك؟ إن شاء الله إنه يكون حق
+
+773
+01:11:51,860 --> 01:11:55,440
+- طبعًا، يعني القصد إنه الـ symptoms أو الـ
+
+774
+01:11:55,440 --> 01:11:57,360
+diagnosis ممكن يعمل reduce للـ general
+
+775
+01:11:57,360 --> 01:12:01,780
+population ويسهل المنطق، الفوصات؟ - لأ، بدك تقول
+
+776
+01:12:01,780 --> 01:12:09,070
+إنه، بدك تقول if not، هذا الـ test بهذه النسب لازم
+
+777
+01:12:09,070 --> 01:12:13,650
+عمله عند وجود الأعراض، إذا ما فيش أعراض ما بصيرش أسويه
+
+778
+01:12:13,650 --> 01:12:20,690
+ماشي؟ يعني مش واحد لأنه قلقان هيك، والله أنا خايف
+
+779
+01:12:20,690 --> 01:12:24,690
+عند الـ Alzheimer ولا ما عنديش، تعال أعمل هذا الـ
+
+780
+01:12:24,690 --> 01:12:29,170
+test موجود عندنا، خليني نعمله، لأ، إذا ما عندكش المرض
+
+781
+01:12:29,170 --> 01:12:33,780
+من قبل راح تدخل حالك في دوامة وتصير تعمل فحوصات
+
+782
+01:12:33,780 --> 01:12:37,260
+وتقلق من أشياء وهو بالأخير بيطلع غلط، أما لو في
+
+783
+01:12:37,260 --> 01:12:41,600
+أعراض، آه لازم تعمله، له قيمة أكبر، وله
+
+784
+01:12:41,600 --> 01:12:47,320
+أهمية، وله validity، يعني valid يعني سليم أو مظبوط
+
+785
+01:12:47,320 --> 01:12:50,060
+إنك تعمله هيك، أو صحيح إنك تعمله
+
+786
+01:12:52,600 --> 01:12:54,140
+- تمام، كنت أتكلم على هذا الأمر في الأخير.
+- تقول
+
+787
+01:12:54,140 --> 01:12:56,920
+على إنك كنت تحصل على هذا، ولا كنت يعني، بس أتأمل
+
+788
+01:12:56,920 --> 01:13:03,080
+إنه واضح يعني، هي الفكرة إنه من ال… إذا لو أنت
+
+789
+01:13:03,080 --> 01:13:08,440
+فاهم الـ Prevalence تبع الـ Disease بالـ Population
+
+790
+01:13:08,440 --> 01:13:14,140
+دوره في الـ Sensitivity والـ Specificity، إذا بسوي
+
+791
+01:13:14,140 --> 01:13:18,260
+أنا Screening، بدي إياه Sensitive، أنا إذا بسوي
+
+792
+01:13:18,260 --> 01:13:24,160
+شيء Screening، بدي إياه عشان أصيب كل الناس اللي عندهم
+
+793
+01:13:24,160 --> 01:13:28,520
+المرض، هذا بيهمني فيه، بس ممكن في الحالة هذه راح
+
+794
+01:13:28,520 --> 01:13:32,920
+أصيب ناس ما عندهمش المرض، فبدي بعدها أسوي specific
+
+795
+01:13:32,920 --> 01:13:37,500
+test اللي هو إنه بتأكد إنه ما عندوش المرض، ما عندوش
+
+796
+01:13:37,500 --> 01:13:41,100
+المرض، يعني بدك تسويها بالـ two steps في هذا
+
+797
+01:13:41,100 --> 01:13:46,480
+الطريق، آه ماشي؟ يا طيب يا عزيزي يا دكتور، الله
+
+798
+01:13:46,480 --> 01:13:51,840
+يحييك، في إذا في أي أسئلة ثانية إن شاء الله خير، أنا
+
+799
+01:13:51,840 --> 01:13:56,580
+بظن الامتحان راح يكون MCQ نفس الـ quiz الأولين
+
+800
+01:13:56,580 --> 01:14:01,620
+ونفس الـ midterm بنفس الطريقة، الله يوفقكم، وشُدّ حيلكم
+
+801
+01:14:01,620 --> 01:14:05,900
+نراكم على خير، دكتور، يعني… يعني امتحان يوم الجمعة إن
+
+802
+01:14:05,900 --> 01:14:11,220
+شاء الله، هيكون فيه أسئلة U word دي، ليش؟ ولا بس
+
+803
+01:14:11,220 --> 01:14:16,600
+أسئلة MCQ قصيرة؟ أنت شو مشكلتك؟ ادرس،  آه
+
+804
+01:14:16,600 --> 01:14:21,780
+يمكن تطلع هنا، يمكن تطلع هنا، ماشي، توفقكم، آه
+
+805
+01:14:21,780 --> 01:14:24,420
+الدورة على… حاضر يا دكتور، حاضر، ماشي، الله
+
+806
+01:14:24,420 --> 01:14:29,520
+يوفقكم، يعطيك العفو يا دكتور، مع السلامة، مع
+
+807
+01:14:29,520 --> 01:14:34,700
+السلامة، يالا نشوفكم على خير، بكرا المساء بودي لك
+
+808
+01:14:34,700 --> 01:14:38,520
+الأسئلة يا دكتور، يعطيك العفو يا دكتور، سلام عليكم
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/DpkVcBuiaNg_raw.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/DpkVcBuiaNg_raw.srt
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@@ -0,0 +1,3233 @@
+1
+00:00:00,000 --> 00:00:04,560
+في آخر المحاضرة الأخيرة احنا استعجلنا شويه هيك بس
+
+2
+00:00:04,560 --> 00:00:11,360
+أظن كانت المفاهيم واضحة ويعني الواحد يعني بالنسبة
+
+3
+00:00:11,360 --> 00:00:21,320
+للطب الحديث الآن بتلاقي الإنسان يعني إمكانية إذا
+
+4
+00:00:21,320 --> 00:00:27,380
+في إمكانيات طبية وصحية في البلاد المتقدمةيعني إنه
+
+5
+00:00:27,380 --> 00:00:31,820
+فعلاً النظام الصحي يعتنب كل إنسان حسب احتياجه وحسب
+
+6
+00:00:31,820 --> 00:00:36,960
+أمراضه وحسب تاريخه المرضى يعني حتى كـ Family
+
+7
+00:00:36,960 --> 00:00:40,960
+History و لا Genetic Testing و لا كذا والآن
+
+8
+00:00:40,960 --> 00:00:45,540
+الأدوات والآلات إذا موجودة وممكن يعني الإمكانات
+
+9
+00:00:45,540 --> 00:00:50,270
+موجودة هتلاقي أمور جميلة ممكن الواحدإذا بعرفها
+
+10
+00:00:50,270 --> 00:00:56,050
+يسويها والكلام بشكل أساسي للأخوة والأخوات الطالبات
+
+11
+00:00:56,050 --> 00:01:02,650
+والطلاب المحاضرة الأخيرة حسب الكتاب عشان إن شاء
+
+12
+00:01:02,650 --> 00:01:10,750
+الله المرات القادمة نسير يعني نراجع الأسئلة
+
+13
+00:01:10,750 --> 00:01:11,350
+التبعات
+
+14
+00:01:13,920 --> 00:01:20,620
+تبعات الـ USMLE أو غيرهم من المراجع التانية إن شاء
+
+15
+00:01:20,620 --> 00:01:24,480
+الله بيكون أحنا يعني عند كل واحد بيقرأ هذه الأسئلة
+
+16
+00:01:24,480 --> 00:01:32,640
+يعني نوع من الفهم وممكن أه يكون فعلاً تمتحن لقدرات
+
+17
+00:01:32,640 --> 00:01:38,060
+الطالب والدكتور بشكل جيد حول المناعة اليوم
+
+18
+00:01:38,060 --> 00:01:44,370
+المحاضرة حقيقة الفصل الأخيربصراحة من أهم الفصول
+
+19
+00:01:44,370 --> 00:01:51,430
+وأنا أعتبرها من أجملها ولكن بالنسبة لي أنا ال ..
+
+20
+00:01:51,430 --> 00:01:57,330
+ال .. بالذات اللي حاطينه هو هم يعني ما بعبر عن شو
+
+21
+00:01:57,330 --> 00:02:01,840
+هيك طموحي أنه نتناقش في هذه الجوانبالجوانب
+
+22
+00:02:01,840 --> 00:02:07,300
+الأخلاقية والجوانب الاجتماعية والجوانب الفكرية في
+
+23
+00:02:07,300 --> 00:02:13,800
+طب الوراشة فالاسم الفصل الأخير في الكتاب قبل ما
+
+24
+00:02:13,800 --> 00:02:17,580
+يدخل في الأمراض وتفاصيلها «ethical and social
+
+25
+00:02:17,580 --> 00:02:23,340
+issues in genetics and genomics» فحقيقة يعني هذا
+
+26
+00:02:23,340 --> 00:02:30,240
+جانب أنا راح أحط مقدمتين، تلاتة حتىعلى الأقل
+
+27
+00:02:30,240 --> 00:02:35,720
+لخلفية كل واحد مننا الإسلامية العربية منطقة الشرق
+
+28
+00:02:35,720 --> 00:02:42,040
+الأوسط في هذا المكان تكون الأمور واضحة ويكون
+
+29
+00:02:42,040 --> 00:02:50,920
+الواحد عنده مبادئ أو نقاط ثابتة أو أسس ثابتة
+
+30
+00:02:50,920 --> 00:02:56,080
+بينطلق منها في التعامل في هذه الجوانبفالجوانب
+
+31
+00:02:56,080 --> 00:03:02,380
+الأخلاقية صراحة من أهم الجوانب وحقيقة الطب يعني
+
+32
+00:03:02,380 --> 00:03:08,560
+وأنا دايما بقول لطلابي إحنا بقوسين وظيفتكم الآن
+
+33
+00:03:08,560 --> 00:03:14,400
+تتعلموا فاحنا مطلوب منها أن نعلمكم ما مطلوب بس أن
+
+34
+00:03:14,400 --> 00:03:18,160
+أعلمكم التشريح والعلوم الطبية وكيف تتعامل مع
+
+35
+00:03:18,160 --> 00:03:24,230
+المريض وكذا فيه جوانب أخلاقية لازم تتعلمهاولازم
+
+36
+00:03:24,230 --> 00:03:28,130
+تعرفها فحقيقة
+
+37
+00:03:28,130 --> 00:03:34,110
+أنا بظن أنه على الأقل الحمد لله بالنسبة أن كمسلمين
+
+38
+00:03:34,110 --> 00:03:41,330
+وعرب أن تاريخ والوضوح
+
+39
+00:03:41,330 --> 00:03:48,390
+كبير جدا وإن كان حتى قبل الإسلام وقبل العرب هناك
+
+40
+00:03:48,390 --> 00:03:53,580
+مبادئ عالميةبيشترك فيها الناس كلها فيه شويه جوانب
+
+41
+00:03:53,580 --> 00:03:59,400
+الأخلاقية في الطب ابتداءًا وبعد ذلك أكتر في الـ
+
+42
+00:03:59,400 --> 00:04:04,080
+الوراثة وعلوم الوراثة والإمكانات الحديثة وكيف
+
+43
+00:04:04,080 --> 00:04:09,420
+الواحد يتعامل مع هذه الجوانب المقدمتين اللي كنت
+
+44
+00:04:09,420 --> 00:04:16,260
+حابب أني أذكرهم أولًا يعني أنا أظن كل واحد منكم
+
+45
+00:04:16,260 --> 00:04:21,890
+بيعرف أنهمجرد ما اتقرر بتخلص من الجامعة وإن شاء
+
+46
+00:04:21,890 --> 00:04:27,290
+الله في حفلة التخرج بتقسم هذا القسم حقيقة قسم مهم
+
+47
+00:04:27,290 --> 00:04:34,970
+وأقرأه ويعني هذا قسم جزء كبير منه مأخوذ حتى من ما
+
+48
+00:04:34,970 --> 00:04:39,750
+يسمى قسم أبقراأبو قراط اللي هو يعتبر من الأسور
+
+49
+00:04:39,750 --> 00:04:46,710
+اليونانية يعني قبل ميلاد سيدنا المسيح بكذا 400
+
+50
+00:04:46,710 --> 00:04:52,570
+سنة، 500 سنة على الأقل لقى مشهور وبيتكلم عن نفس
+
+51
+00:04:52,570 --> 00:04:56,650
+المبادئ وإن كان يعني إذا حد قرأ نفس القسم القديم
+
+52
+00:04:57,020 --> 00:05:02,380
+علاقي إنه بيتكلم إنه بيحلف في أبولو ملك إله الطب
+
+53
+00:05:02,380 --> 00:05:08,360
+يعني بيخبص تخبصاتهم بس المبادئ الأساسية فإحنا لما
+
+54
+00:05:08,360 --> 00:05:12,820
+الواحد مننا يقسم أقسم بالله العظيم أن أراقب الله
+
+55
+00:05:12,820 --> 00:05:17,560
+في مهنتيه وأن أسونا حياة الإنسان في كافة أدواره في
+
+56
+00:05:17,560 --> 00:05:22,760
+كل الظروف والأحوال باذلا وسعي استنقاذها من الهلاك
+
+57
+00:05:22,760 --> 00:05:28,570
+والمرض والألم والقلقمطلوب منه أن أحافظ على الإنسان
+
+58
+00:05:28,570 --> 00:05:32,590
+اللي أمامنا من الهلاك والمرض والألم والقلق وأن
+
+59
+00:05:32,590 --> 00:05:38,310
+أحفظ للناس كرامتهم وأستر عورتهم وأكفتهم سرهم وأن
+
+60
+00:05:38,310 --> 00:05:42,470
+أكون على الدوام من وسائل رحمة الله بادلا رعاية
+
+61
+00:05:42,470 --> 00:05:47,810
+الطبية للقريب والبعيد للصالح والخاطر والصديق
+
+62
+00:05:47,810 --> 00:05:52,710
+والعدو وأن أثابر على طلب العلم وسأسخره لدفع
+
+63
+00:05:52,710 --> 00:05:57,570
+الإنسان لا لأذاهوأن أوقّر من علّمني وأعلم من
+
+64
+00:05:57,570 --> 00:06:01,590
+يصغرني وأكون أخل لكل زميل في المهنة الطبية
+
+65
+00:06:01,590 --> 00:06:07,030
+متعاونين على البر والتقوى وأن تكون حياتي مصداقة
+
+66
+00:06:07,030 --> 00:06:12,550
+إيماني في سرّي وعلى نيتي نقية مما يشينها تجاه الله
+
+67
+00:06:12,550 --> 00:06:17,270
+ورسوله والمؤمنين الله على ما أقول شهيد عقيقة يعني
+
+68
+00:06:17,270 --> 00:06:23,810
+مبادئ أنا بعتبر حفظ كرامة الإنسان حفظ سر الإنسان
+
+69
+00:06:24,280 --> 00:06:32,820
+حفظ الأحداث من الهلاك والمرض والألم والقلق وتعامل
+
+70
+00:06:32,820 --> 00:06:36,640
+مع الزملاء وغيرها هذه المبادئ الأخلاقية العامة
+
+71
+00:06:36,640 --> 00:06:44,960
+الطبية وهي مشمولة في القسم حقيقة لازم واحد يكون
+
+72
+00:06:44,960 --> 00:06:51,280
+متنبه لها ويكون مطبق لها يعني يتشربها ويعتبرها
+
+73
+00:06:51,280 --> 00:06:58,590
+مبادئتحكم تفكيره وتحكم يعني تصرفاته يعني ما بيصير
+
+74
+00:06:58,590 --> 00:07:02,630
+الواحد يكون مثلا فقط وظيفته أنا بدي أصبح دكتور
+
+75
+00:07:02,630 --> 00:07:09,930
+عشان ألم مصاري وأجرم الناس جرم بالمصاري وأكون احتم
+
+76
+00:07:09,930 --> 00:07:16,530
+مريض بدفع ودفيع وعنده مصاري أدور عليه واتقاتل أنا
+
+77
+00:07:16,530 --> 00:07:21,900
+والملاقمين راح يعمل العملية ومين راح يعالج هذا
+
+78
+00:07:21,900 --> 00:07:28,260
+المريض ولا كذا ولا كذا فحقيقة قسم
+
+79
+00:07:28,260 --> 00:07:33,960
+الطبيب من الأول وهذا ستاخدوه إن شاء الله في حفلة
+
+80
+00:07:33,960 --> 00:07:39,380
+التخرج أتوقع هيقعد في الدنيا كلها إنه كل واحد يجب
+
+81
+00:07:39,380 --> 00:07:44,120
+أن يقسم هذا ويجب الواحد مننا أن يعتبر هذا القسم
+
+82
+00:07:44,120 --> 00:07:49,480
+والميتاقبينه وبين الله الذي يراقبه بالسر والعلان
+
+83
+00:07:49,480 --> 00:07:56,720
+لوحدك ولا مع غيرك ولا كده لما
+
+84
+00:07:56,720 --> 00:08:01,660
+تكون طبيب تتعامل معاه إن شاء الله تكون المفاهيم
+
+85
+00:08:01,660 --> 00:08:05,620
+واضحة وإذا في حد عنده استفسار يا دكتور أحمد يكلمني
+
+86
+00:08:05,620 --> 00:08:13,740
+ماشي يعني الواحد بيكمل المحاضرة لما
+
+87
+00:08:13,740 --> 00:08:24,090
+تتعاملوترى بعد ذلك ما الذي يحكمك ما الذي يعني أنت
+
+88
+00:08:24,090 --> 00:08:32,350
+مطالب بتنفيذه وتنفيذه في حياتك
+
+89
+00:08:32,350 --> 00:08:41,810
+الطبية كطبيب في المجتمعهناك يعني من الـ يمكن في
+
+90
+00:08:41,810 --> 00:08:47,150
+فترة أن يكون الطالب يعني
+
+91
+00:08:47,150 --> 00:08:53,630
+في أعلى مقاعد الدراسة قد لا يكون عنده احتكاك وتفهم
+
+92
+00:08:53,630 --> 00:09:01,850
+ويعني وتطبيق لجوانب مفروض أساسية يكون الواحد فاهم
+
+93
+00:09:01,850 --> 00:09:12,130
+إحنا في أي بلدهناك قانون للصحة وهناك شيء اسمه
+
+94
+00:09:12,130 --> 00:09:18,470
+قانون الصحة زي قانون السير، زي قانون وزارة التعليم
+
+95
+00:09:18,470 --> 00:09:21,750
+وعنا يعني في القردن، لا أعرف إيش كانت النظام في
+
+96
+00:09:21,750 --> 00:09:27,590
+غزة بالنسبة كتطبيق يعني اللي هناك تلت أو أربع
+
+97
+00:09:27,590 --> 00:09:32,650
+درجات من الأنظمة والأشياء اللي احنا بنفتق عليها،
+
+98
+00:09:32,650 --> 00:09:38,080
+يعني بالأخيروالله أنا بسوق بالسيارة، دخلت عدوار،
+
+99
+00:09:38,080 --> 00:09:42,380
+دا عامة، بس يقول عليك أنت الحق، يقولك لأ أنت عليك
+
+100
+00:09:42,380 --> 00:09:46,780
+الحق، احنا بنحتكم لقانون، حتى لو ما انتبهناش، بس
+
+101
+00:09:46,780 --> 00:09:51,580
+احنا محكمين بالقانون، ولا بتصير حياة البشر غابة،
+
+102
+00:09:51,580 --> 00:09:58,300
+فالقانون طبعا أعلى قوانين أي مجتمع ما يسمى دستور
+
+103
+00:09:59,300 --> 00:10:02,440
+يمكن في غزة، ماعرفش كيف النظام يكون مائي بالمائي
+
+104
+00:10:02,440 --> 00:10:07,680
+بس بحكي عن الأردن الدستور الأردني الدستور هو يعني
+
+105
+00:10:07,680 --> 00:10:12,220
+شيء حتى في أمريكا الدستور الأمريكي وتعديلاته وكذا
+
+106
+00:10:12,220 --> 00:10:16,620
+وكذا كان المبادئ الحاكمة الأساسية للعقد الاجتماعي
+
+107
+00:10:16,620 --> 00:10:23,500
+للمجتمع بأكبر فالدستور يعني هو أساس القوانين
+
+108
+00:10:23,500 --> 00:10:30,890
+جميعًاوبالتالي هو الذي يعني يحكم كل شيء ويكون فيه
+
+109
+00:10:30,890 --> 00:10:37,270
+مبادئ عامة تمثل هوية المجتمع وهمية الدولة ومبادئها
+
+110
+00:10:37,270 --> 00:10:41,750
+وقيمها وجوانب تفصيلية أخرى للقضايا الكلية زي ما
+
+111
+00:10:41,750 --> 00:10:47,630
+بقول القانون يعني بيجي بعد الدستور هناك القوانين
+
+112
+00:10:48,200 --> 00:10:52,380
+القوانين زي قانون الصحة، قانون السير، قانون
+
+113
+00:10:52,380 --> 00:10:56,860
+العقوبات، قانون الجوانب
+
+114
+00:10:56,860 --> 00:11:01,240
+الكثيرة هنا، القانون الاقتصادية القانون إنها هو
+
+115
+00:11:01,240 --> 00:11:10,890
+الشيء الذيأو الأحكام أو المنظمة لنا اللي يعني في
+
+116
+00:11:10,890 --> 00:11:16,310
+الأردن تقترحها الحكومة لوافق عليها البرلمان
+
+117
+00:11:16,310 --> 00:11:21,470
+بالبرلمان اللي هو يعني المجلس النواب ومجلس العيال
+
+118
+00:11:21,470 --> 00:11:27,190
+أنها برلمانينوبعد ذلك بس يتم الموافق عليها والكل
+
+119
+00:11:27,190 --> 00:11:31,970
+يشترك في الموافق عليه توشح بإرادة ملكية ورئيس
+
+120
+00:11:31,970 --> 00:11:37,690
+الدولة أو الحكم بوافق عليها فهي يعني أعلى بعد
+
+121
+00:11:37,690 --> 00:11:42,490
+الدستور تيجي مرتبة ثانية بعدين هناك ما يسمى
+
+122
+00:11:42,490 --> 00:11:47,850
+الأنظمة الأنظمة ونظام زي مثلا نظام جامعة العلوم
+
+123
+00:11:47,850 --> 00:11:54,580
+والتكنولوجيا شايف عليك؟فالنظام هو يعني برضه
+
+124
+00:11:54,580 --> 00:12:01,320
+تعليمات نابعة من قانون بقوم الوزير، هو يعني صلاحية
+
+125
+00:12:01,320 --> 00:12:05,740
+الوزير لما أننا بدنا نغير في النظام إشي الوزير هو
+
+126
+00:12:05,740 --> 00:12:10,240
+اللي بيقدر يغير، مافيش داعي لمدّس نواب ومدّس عيال
+
+127
+00:12:10,240 --> 00:12:15,540
+وإرادة ملكية والمبادئ، هذا القانون، و بعدين في
+
+128
+00:12:15,540 --> 00:12:21,180
+داخل المؤسسةيعني هذه اللي مثلا عندنا وزير التعليم
+
+129
+00:12:21,180 --> 00:12:27,600
+العالي بيصدر بيسموه نظام الجامعات أو نظام كذا لإن
+
+130
+00:12:27,600 --> 00:12:30,780
+احنا اللي نحكم فيه وبعدين المستوى الأخير بيسموه
+
+131
+00:12:30,780 --> 00:12:35,020
+التعليمات التعليمات يعني أي مؤسسة زي جامعة العلوم
+
+132
+00:12:35,020 --> 00:12:39,740
+والتكنولوجيا الهندنية عندها تعليمات ترقية عضاء
+
+133
+00:12:39,740 --> 00:12:44,220
+الهيئة التدريس تعليمات نظام الإجازات أو تعليمات
+
+134
+00:12:44,220 --> 00:12:48,880
+الإجازات في هذه المؤسسةفالمهم، يعني الفكرة في هذا
+
+135
+00:12:48,880 --> 00:12:53,880
+الموضوع إنه الواحد مننا بده يكون متنبه لهذه
+
+136
+00:12:53,880 --> 00:12:58,700
+الأهمية هذه الجوال، بقول عشان هيك يعني البرلمانات،
+
+137
+00:12:58,700 --> 00:13:02,520
+إشي مهم، إحنا ما ناخدها إن والله هاي سياسي وشكلي
+
+138
+00:13:02,520 --> 00:13:07,480
+ومالهاش دخل، إحنا محكمين فيها، إحنا كشخاص قانون
+
+139
+00:13:07,480 --> 00:13:10,560
+السير بيمشي عليا، لو في إشي غلط بقانون السير،
+
+140
+00:13:10,560 --> 00:13:13,840
+المفروض يعدّل، يعني مش هالإشي الكبير، يعني
+
+141
+00:13:13,840 --> 00:13:19,410
+والسياسة 90% منهابتنظيم حياة الناس بتكون أشياء
+
+142
+00:13:19,410 --> 00:13:23,790
+يعني مش سهولة منك تتفق أجمع العقلة من الناس
+
+143
+00:13:23,790 --> 00:13:28,710
+الكبيرة فيها يعني فكل
+
+144
+00:13:28,710 --> 00:13:34,030
+بلد إلها قوانين وبدوا الواحد يكون فاهم شو قانون
+
+145
+00:13:34,030 --> 00:13:38,150
+البلد اللي أنا فيه قانون الصحة مثلا إنه أو راح
+
+146
+00:13:38,150 --> 00:13:42,250
+نيجي مثلا ندخل على مثلا سرية المعلومة وعدم سرية
+
+147
+00:13:42,250 --> 00:13:48,050
+المعلومة أنا بقولأحنا الأول أنا محكوم بقانون الصحة
+
+148
+00:13:48,050 --> 00:13:52,710
+ثم أمر المحكمة يعني مثلا عندنا في القانون في
+
+149
+00:13:52,710 --> 00:13:58,430
+الأردن بسبب يعني تأثيره على الصحة العامة إنسان
+
+150
+00:13:58,430 --> 00:14:07,050
+عنده ثلج إنسان عنده مثلا التهاب الكبد الوبائي B أو
+
+151
+00:14:07,050 --> 00:14:13,340
+Cالـ Malaria المش عارف، هذه أمراض كذا ثبت إن إنسان
+
+152
+00:14:13,340 --> 00:14:18,600
+عنده هذا المرض فبالقانون بالقانون التابعة الصحة
+
+153
+00:14:18,600 --> 00:14:24,360
+هناك تعريف للأمراض التي يجب أن تبلغ عنها هو طبعا
+
+154
+00:14:24,360 --> 00:14:28,300
+يعني عادة مش الطبيب اللي ببلغ بس عادة حتى المختبر
+
+155
+00:14:28,300 --> 00:14:33,860
+في نظام يقول في المختبر إنه لما تكون الحالة
+
+156
+00:14:33,860 --> 00:14:39,430
+الفلانية هي اللي تم تشخيصها يتم التبلغ والسببحتى
+
+157
+00:14:39,430 --> 00:14:43,410
+لو الإنسان أراد أو لم يرد هناك واجب للمجتمع يحمي
+
+158
+00:14:43,410 --> 00:14:50,870
+المجتمع إنه مرته وولاده جيرانه يمكن شخص مخالط له
+
+159
+00:14:50,870 --> 00:14:55,990
+بدك تفحص بدك تشوفه بدك تحميه بدك تنبهه إنه يعني
+
+160
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+داخل على حالة مرض يعني مثلا ممكن نقول حتى لو الـ
+
+161
+00:15:00,970 --> 00:15:04,670
+COVID تبعنا في الأيام الحياة هذه يعني بعض الناس
+
+162
+00:15:04,670 --> 00:15:12,780
+إذا أصيبممكن يعني أكبر مثال هذا يعني رئيس الولايات
+
+163
+00:15:12,780 --> 00:15:16,920
+المتحدة الأمريكية مهمل للموضوع مش مصدق إنه هذا
+
+164
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+مرضه بيخوف وكده لا بديه بس كان معمل ومهمل وعشان هي
+
+165
+00:15:22,340 --> 00:15:25,200
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+167
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+
+168
+00:15:37,300 --> 00:15:41,400
+مثلًا إنه قانون للصحة وقانون لنقابة الأطباء أو
+
+169
+00:15:41,400 --> 00:15:47,160
+نظام لنقابة الأطباء أظن وفيه إلاج وتعليمات يجب أن
+
+170
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+الواحد ينتبه للمسميات هذه ويشوف هو في التعامل مع
+
+171
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+الصحة في مكانه ما الذي ينطبق عليه شوف قانوني
+
+172
+00:15:58,560 --> 00:16:02,320
+القانون الصحي التابعي بالزمن بماذا وهذه القضية
+
+173
+00:16:02,320 --> 00:16:06,900
+بدأت تكون واضحةفتمّى لأن الموضوع واضح هنا قانون
+
+174
+00:16:06,900 --> 00:16:14,300
+الصحة في أسئلة؟
+
+175
+00:16:14,300 --> 00:16:18,640
+تمام يا دكتور ما في حد سأله الله يرضى عليك المبدأ
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+176
+00:16:18,640 --> 00:16:25,720
+التاني مبدأ مبادئ حقوق الإنسان بالذات سنة 1948
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+177
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+اتفق العالم يعنيأحنا خصوصيتنا أحنا مسلمين أحنا عرب
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+178
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+179
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+الأوسط وعنا مبادئ معينة ولكن يعني وهناك يعني مبادئ
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+180
+00:16:49,680 --> 00:16:56,920
+ضمنا تعتبر كل البلاد الموقع عليها مشتركة فيها اللي
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+181
+00:16:56,920 --> 00:17:04,190
+هي مبادئ حقوق الإنسانوهذه أنا في 99% منها لا
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+182
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+أعتبرها وعلى أكثر أعتبر الإسلام هو اللي بيدعى لها
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+يعني لما تسمع مقولة سيدنا عمرو اللي خطاب «ما
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+184
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+تستعبدتم الناس وقد ولدتهم أمهاتهم أحرارة» يعني
+
+185
+00:17:16,530 --> 00:17:21,670
+مبادع حقوق الإنسان لمجرد إنه إنسان عربي، مسلم،
+
+186
+00:17:21,670 --> 00:17:28,360
+هندي، تعتبره أسود، أبيض، شلعرفيعني حتى دائما يُذكر
+
+187
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+أنه على مدخل جامعة «هارفرد» يقول لك ذكر سيدنا محمد
+
+188
+00:17:34,660 --> 00:17:39,440
+صلى الله عليه وسلم أنه لا أفضل عربي على عجمي ولاد
+
+189
+00:17:39,440 --> 00:17:44,440
+أو على أبيض على أسود إلا بالتقوى، ناشي؟ فهناك
+
+190
+00:17:44,440 --> 00:17:48,180
+مبادئ لحقوق الإنسان حقه في الحياة، حقه في الصحة،
+
+191
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+حقه في التعليم حقه في حرية التنقل، حقه في إبداء
+
+192
+00:17:53,620 --> 00:17:59,650
+الأفكار، حق يعني المبادئفسنة 48 كانت أول مبادئ
+
+193
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+لحقوق الإنسان وهذا يعني ما تم التوافق عليه وأنا
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+196
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+الشخص اللي أمامك النازيين
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+197
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+الألمان الحرب العالمية التانية أو قبلهاكان عندهم
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+198
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+يعني حقيقةً تجاوزات شديدة جداً في الناحية يعني
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+199
+00:18:33,800 --> 00:18:38,820
+العلم ما بين الحربين العالميين كان أكتر مكان متقدم
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+200
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+201
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+
+202
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+من غيرهموإنه لمجرد إنك أنت ألماني لمجرد إنك أنت
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+203
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+أسود أو أبيض أبيض على أسود تعتبر إنه من حقه يعمل
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+204
+00:19:00,250 --> 00:19:05,290
+أي شيء فكانوا يقتلوا المتخلفين عقلياً مش بس اليهود
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+205
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+207
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+208
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+يعني احنا مش بعيدين عنهم، كانت اسياق سيئة فعمله
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+211
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+212
+00:19:40,880 --> 00:19:46,430
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+213
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+215
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+اشترك لبقى التجربة ويمكن تموت فيها بس نعفيك من
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+216
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+217
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+
+219
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+يعني صيدوا وأثروا الأطباء والعلماء الألمان اللي
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+220
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+أجروا تجارب بالذات اليهود وكان التجارب يعني علمياً
+
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+من أدق التجارب من أفضل التجارب استفدنا منها كتير
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+224
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+225
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+226
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+228
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+237
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+منها إنه لازم البحث يأخذ مؤافقة اللي يسموه IRB الـ
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+238
+00:22:02,650 --> 00:22:08,290
+Institutional Review Board يعني لجنة تقييم
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+239
+00:22:08,290 --> 00:22:14,050
+أخلاقيات البحث هل هذا البحث يعني أنا إذا بعمل
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+
+243
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+باحثك هذا كويس، اعمله» يعني أنا بتيجي إن استشارات
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+
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+
+251
+00:23:02,720 --> 00:23:07,340
+يعني أنا بشتغل في جامعة العلوم التكنولوجية
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+252
+00:23:07,340 --> 00:23:11,640
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+253
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+255
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+
+256
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+
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+
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+غلط الواحد دايما يذكر الخير لأهله أنا روحت على
+
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+أمريكا بالـ 91 وأول مرة يعني أنا كنت في الكويت
+
+264
+00:24:05,530 --> 00:24:09,390
+وإنا أتجارب في مجتمع قريب من غزة في الكويت كيف
+
+265
+00:24:09,390 --> 00:24:13,790
+الناس بتتعامل مرات كتير في أشياء كتيرة إحنا عندنا
+
+266
+00:24:13,790 --> 00:24:20,500
+في بلادنابتروح بتأمن سيارة، بتروح بتتوظف في مكان،
+
+267
+00:24:20,500 --> 00:24:25,320
+ولمّا ودّوني بقيت، هل بتتعامل مع بنك تأخذ قرن،
+
+268
+00:24:25,320 --> 00:24:28,880
+بيبعتوك صفتة الأوراق والمسئول بيقول لك وقّع هون
+
+269
+00:24:28,880 --> 00:24:32,180
+وقّع هون وقّع هون وقّع هون وقّع هون وانت مش فقار
+
+270
+00:24:32,180 --> 00:24:36,440
+ومش فاهم ومش عامل أيش، فاهم عليك؟ انت ملزم وخلاص
+
+271
+00:24:36,440 --> 00:24:41,280
+وقّع، والله لما كنت في أمريكا أول ما اشتغلت في
+
+272
+00:24:41,280 --> 00:24:46,980
+المستشفى وانا بوقع العقد معهماللي انضميت لهم عطوني
+
+273
+00:24:46,980 --> 00:24:54,760
+ليست أوراقها القدّي حقوقي وواجباتي بشكل تفصيلي شو
+
+274
+00:24:54,760 --> 00:24:59,700
+لازم أعمل وكيف أتصرف طبعا يمكن الواحد أولها ماكانش
+
+275
+00:24:59,700 --> 00:25:04,260
+فاهم كتير بس فعلا بقلال تعاملي معهم فعلا برجع
+
+276
+00:25:04,260 --> 00:25:13,780
+للمبادئ هذه وعقدت أخيرا إحنا مسلمينحقيقةً النظام
+
+277
+00:25:13,780 --> 00:25:21,220
+الإسلامي هو أرقى وأفضل وأعلى نظام يعني بشري أنا
+
+278
+00:25:21,220 --> 00:25:25,380
+عشان هيك بقول مثلا مبادئ حقوق الإنسان ومبادئ
+
+279
+00:25:25,380 --> 00:25:29,360
+العالمية بفهمها في ضوء الإسلام هذا قرار الشخصي
+
+280
+00:25:29,360 --> 00:25:35,360
+اللي بسميه بس يعني أنا بشوف إنها كثير متوافقة مع
+
+281
+00:25:35,360 --> 00:25:40,850
+مبادئ الدين الإسلاميومنظمة إله والواحد يتذكر إنه
+
+282
+00:25:40,850 --> 00:25:46,890
+في الدنيا مش لوحده يعني ممكن بسهولة الإنسان يسافر
+
+283
+00:25:46,890 --> 00:25:52,090
+يكون حتى في سفره يدخل في بلاد تانية بدي يكون البشر
+
+284
+00:25:52,090 --> 00:25:57,310
+يعني وغير ذلك تكون الحياة غابة القوية أكلت ضعيفك
+
+285
+00:25:57,310 --> 00:26:01,770
+بغير يعني بتعدي أو ضلم
+
+286
+00:26:05,210 --> 00:26:10,550
+الإسلام يعني من الأشياء اللي يجب كمسلم وعربي يكون
+
+287
+00:26:10,550 --> 00:26:14,430
+الواحد واضح عنده بالذات في الأمور بين قوسين
+
+288
+00:26:14,430 --> 00:26:21,950
+الفقهية يعني الدين، ديننا، في أشياء علوم غيبية إذا
+
+289
+00:26:21,950 --> 00:26:25,850
+واحد بيقول مافيش آخرة ومش حاسب أسابي الآخر وفي جن
+
+290
+00:26:25,850 --> 00:26:30,410
+ونار، هو حر طبعا هذا الجانب ربنا اللي بعرفه، يعرف
+
+291
+00:26:30,410 --> 00:26:36,280
+شو قلب الواحدوشو يعني جوا وفكري الواحد وليش الواحد
+
+292
+00:26:36,280 --> 00:26:40,660
+بيستوي هذا الموضوع بس في الأمور الفقهية الفقهية
+
+293
+00:26:40,660 --> 00:26:45,180
+لما نقول فقه يعني هذا من المبادئ الجميلة أنا أمين
+
+294
+00:26:45,180 --> 00:26:48,560
+سير جمعية العلم الطبية الإسلامية في نقاط الأطباء
+
+295
+00:26:48,560 --> 00:26:53,580
+الوردنية الفقه
+
+296
+00:26:53,580 --> 00:26:59,930
+هو الجانب العملي من العبادات ومن المبادئيعني
+
+297
+00:26:59,930 --> 00:27:06,790
+الجوانب العملية كيف تصلي، كيف تصوم، أي فقه كيف
+
+298
+00:27:06,790 --> 00:27:13,410
+تتزوج، كيف تطلق، أي فقه كيف مثلا تبيع وتشتري، فقه
+
+299
+00:27:13,410 --> 00:27:19,090
+لأنه أمور عملية مش علوم غيبية أو علوم يعني فكرية
+
+300
+00:27:19,090 --> 00:27:25,310
+مطلوبة من الإنسان والإيمان مطلوب وضروري على الأقل
+
+301
+00:27:25,310 --> 00:27:30,320
+إيمان من الجنة والنار والحساب والإيقافففي القيقه
+
+302
+00:27:30,320 --> 00:27:37,720
+يقال هناك فيه مقاصد وقواعد المقاصد يجمعها قضية
+
+303
+00:27:37,720 --> 00:27:43,680
+مهمة هي الضرورات الخامسة يعني إحنا لما نتعامل
+
+304
+00:27:43,680 --> 00:27:50,700
+الإسلام بينظر ضرورة المحافظة على الدين على الحياة
+
+305
+00:27:50,700 --> 00:27:57,960
+أو النفس على العقل على العرض وعلى المال والحقوق
+
+306
+00:27:59,630 --> 00:28:04,710
+ماشي، فهذه مقاصد الشريعة الإسلام يقول لك ما بجزء
+
+307
+00:28:04,710 --> 00:28:08,950
+منك تأخذ الفلس من بني آدم آخر إذا ما هو راضي وعن
+
+308
+00:28:08,950 --> 00:28:16,630
+طيب خاطر وعن قناعه، غير هيك إذا ما يعني فهذه مقاصد
+
+309
+00:28:16,630 --> 00:28:21,370
+الشريعة للحفاظ على هذه الأمور والحفاظ على الصحة هو
+
+310
+00:28:21,370 --> 00:28:28,340
+من مقاصد الحفاظ على الحياةفالـ يعني يكفي الإنسان
+
+311
+00:28:28,340 --> 00:28:35,480
+فقر إن الله سبحانه وتعالى في يعني بعد ذكر قصة أبيل
+
+312
+00:28:35,480 --> 00:28:40,320
+وأبيل في القرآن الكريم يعني بيدكر من أجل ذلك كتبنا
+
+313
+00:28:40,320 --> 00:28:46,000
+على بني إسرائيل أنه من قتل نفسا بغير نفسه فكأنه
+
+314
+00:28:46,000 --> 00:28:49,920
+فكأنه ما قتل الناس جميعه ومن أحياه فكأنه ما أحيى
+
+315
+00:28:49,920 --> 00:28:54,160
+الناس جميعها أظن أني ممكن خربطت الآية شوية بس ومن
+
+316
+00:28:54,160 --> 00:28:59,750
+أحياهفكأنما أحيى الناس جميعًا يعني يوم من قتل
+
+317
+00:28:59,750 --> 00:29:02,790
+الهبيل يعني الواحد يقول نص البشرية ربع البشرية
+
+318
+00:29:02,790 --> 00:29:09,370
+ماتت الواحد يعني ينقل حياة إنسان هذا من مقاصد
+
+319
+00:29:09,370 --> 00:29:14,770
+الشرق الأساسية فهناك مقاصد يجب أن يفهمها الواحد
+
+320
+00:29:14,770 --> 00:29:20,410
+ينظر في التراث الإسلامي ومبادئ العظيمة من القرآن
+
+321
+00:29:20,410 --> 00:29:24,210
+الكريم القرآن يعني
+
+322
+00:29:25,410 --> 00:29:32,510
+يعني هو رسالة الله إلى البشرية الخالدة الرسالة
+
+323
+00:29:32,510 --> 00:29:38,670
+يعني أنا بحكي كثير للأصدقاء اللي كنا في أمريكا وفي
+
+324
+00:29:38,670 --> 00:29:45,010
+دول تانية مؤتمرات أو غيره أنه اللي لما نحنا نتكلم
+
+325
+00:29:45,010 --> 00:29:51,710
+عن القرآن الانجليزي نفسهم انجليزي شيكسبير اللي هو
+
+326
+00:29:51,710 --> 00:29:57,520
+عاش قبل 400 سنة بسوتعطيهم الكلام اللي ذكره شيكسبير
+
+327
+00:29:57,520 --> 00:30:03,040
+نفسه لا يفهموه فطبعا التوراة والإنجيل ما حد بيقدر
+
+328
+00:30:03,040 --> 00:30:05,980
+يقول أنه الآن اللي بين إيديهم توراة وإنجيل هي
+
+329
+00:30:05,980 --> 00:30:10,120
+توراة وإنجيل اللي نزلت على سيدنا موسى وعيسى عليه
+
+330
+00:30:10,120 --> 00:30:15,080
+السلام بينما القرآن الكريم محفوظ بحفظ الله سبحانه
+
+331
+00:30:15,080 --> 00:30:20,260
+وتعالى وكذلك كثير من السنة النبوية محفوظة ولغتها
+
+332
+00:30:20,260 --> 00:30:24,830
+محفوظة وثابتة إلى يوم القيامةهذه حقيقة المعجزة
+
+333
+00:30:24,830 --> 00:30:30,230
+الإسلام إنه يعني شغل ما تغيرت طيل هذا السنين
+
+334
+00:30:30,230 --> 00:30:36,770
+والعقود وألاف السنين وهي ثابتة لا تتغير عندما تتلو
+
+335
+00:30:36,770 --> 00:30:40,730
+القرآن الكريم فانت تتلوه كما تلاه سيدنا محمد صلى
+
+336
+00:30:40,730 --> 00:30:45,050
+الله عليه وسلم في لغة قبل ذلك اتثرت قبل 200 سنة من
+
+337
+00:30:45,050 --> 00:30:51,090
+الإسلام فمقاصد الشرق المفروض الواحد يتنبهها إلها
+
+338
+00:30:51,090 --> 00:30:58,570
+وقواعدهناك قواعد شرعية في الفقه، قواعد فقهية كأنا
+
+339
+00:30:58,570 --> 00:31:05,050
+كنا في دورات فقهية الصراحة يعني فيها بيات شعر
+
+340
+00:31:05,050 --> 00:31:12,210
+جميلة جدا ذُكرت لنا في حفظتها، وأذكركم إياها
+
+341
+00:31:12,210 --> 00:31:20,110
+أحدهم، نسيت العالم اللي ذكرها، يقولخمس مقررة قواعد
+
+342
+00:31:20,110 --> 00:31:27,770
+مذهب للشافعية فكن بهنا علينا خمس قواعد وهي جملة
+
+343
+00:31:27,770 --> 00:31:32,650
+تعطي قاعدة تنطبق على مسائل الفقهية كثيرة حتى
+
+344
+00:31:32,650 --> 00:31:38,950
+الواحد يحكم خمس مقررة قواعد مذهب للشافعية فكن بهنا
+
+345
+00:31:38,950 --> 00:31:43,970
+علينا الإمام الشافعي رضي الله عنه كان من أهم
+
+346
+00:31:43,970 --> 00:31:49,660
+المؤثرين للفقهوأصول الفتاة وأصول الدين غيرها من
+
+347
+00:31:49,660 --> 00:31:54,460
+المبادر حقيقة الإنسان عظيم فالإمام الشافعي هذا
+
+348
+00:31:54,460 --> 00:31:58,320
+اللي بقوله عن الإمام الشافعي عنده خمس قواعد ضرر
+
+349
+00:31:58,320 --> 00:32:04,200
+يزال وعادة قد حُكمت وكذا المشاقة تجلب التيسيرة
+
+350
+00:32:04,200 --> 00:32:12,960
+والشك لا تحفع به متيطنا وقصد أخلص إن أردت أجورة هو
+
+351
+00:32:12,960 --> 00:32:19,860
+قواعده اللي هي أنهفي الفقه والشرع والدين أولاً أنه
+
+352
+00:32:19,860 --> 00:32:24,100
+لا ضرر ولا درار وحتى في كتابكم الآن حيجيب يقولك لا
+
+353
+00:32:24,100 --> 00:32:28,660
+ضرر ولا درار يعني هناك طبعاً قواعد سرعية هي قواعد
+
+354
+00:32:28,660 --> 00:32:32,740
+الكلية كما يقال يعني دائماً من القواعد الفقهية
+
+355
+00:32:32,740 --> 00:32:39,490
+تقال أحياناً دفع الضرر مقدم على جانب المنفعوالله
+
+356
+00:32:39,490 --> 00:32:47,250
+أنا حرام بدي أجيب مروحة أحطها عليّ وأنا عشاني حرام
+
+357
+00:32:47,250 --> 00:32:51,050
+ييجي واحد بس أنا حرام شوية يعني مش مشكلة مش ضارة
+
+358
+00:32:51,050 --> 00:32:57,610
+كبيرة فينما اللي جنبي عنده رشحة ولا عنده مرض فهويت
+
+359
+00:32:57,610 --> 00:33:03,490
+عليه المروحة هذه القضية تجلب له مرض فعندها لأ
+
+360
+00:33:03,490 --> 00:33:08,310
+بنقول بنطفل المروحة بنضويهاش لأنهدفع المضارة مقدّم
+
+361
+00:33:08,310 --> 00:33:13,490
+على جلب المنطقة في هذه الطريقة فضرر يزالي وهذا في
+
+362
+00:33:13,490 --> 00:33:19,050
+حديث الرسول ﷺ لا ضرر ولا ضرار ويعني من المبادئ إنه
+
+363
+00:33:19,050 --> 00:33:24,710
+لا ضرر ولا ضرار بعدين وعادة قد حُكّم إذا الناس
+
+364
+00:33:24,710 --> 00:33:31,670
+اتفقوا على عاد معين وما في لها مخالفة شرعية الأمر
+
+365
+00:33:31,670 --> 00:33:37,520
+يعني يُلتفت له ويُحكمالإمام الشافعي كان بالعراق
+
+366
+00:33:37,520 --> 00:33:42,000
+كان يحكم الطريقة ويفت الطريقة راح على مصر صار يفت
+
+367
+00:33:42,000 --> 00:33:45,300
+الطريقة تاني قالوله يا شيخ أنت في العراق كنت تفت
+
+368
+00:33:45,300 --> 00:33:49,880
+فت هيك قالت آه كنا في وضع وكانت فت هيك صرنا في وضع
+
+369
+00:33:49,880 --> 00:33:54,320
+آخر بنفت الطريقة اللي حسبناها يعني أنا مثلا مشهورة
+
+370
+00:33:54,320 --> 00:34:00,460
+من الشغلات اللي نذكرها مثلا الـ Jesus عندنا في
+
+371
+00:34:00,460 --> 00:34:07,790
+فلسطين والأردن وكذاودول كثيرة معروف الذلمي بتدفع
+
+372
+00:34:07,790 --> 00:34:13,830
+كل إشي البيت والشقة والأثات والمهر وكذا الذلمي
+
+373
+00:34:13,830 --> 00:34:18,770
+بتدفع كل إشي هيك عادت الناس والواحد هو حظه الذلمي
+
+374
+00:34:18,770 --> 00:34:28,730
+بده يدفع إذا زوجة بتدفنها أما في مصر معروف الشقة
+
+375
+00:34:28,730 --> 00:34:35,020
+على الذلمي والأثات على المرأةخلاص هي عادة الناس
+
+376
+00:34:35,020 --> 00:34:40,000
+وعرفهم إنهم بيعملوا هيك مدام متفقين عليه في الشرع
+
+377
+00:34:40,000 --> 00:34:44,580
+وفي الدين هذا يصبح أصل شرعي وعادة قد حُكّمه فيجب
+
+378
+00:34:44,580 --> 00:34:49,940
+القاضي ولا كده يحكم حسب عرفه في آية في القرآن وأمر
+
+379
+00:34:49,940 --> 00:34:53,400
+بالعرف العرف ما تعرف عليه الناس حتى ما يصير خلاف
+
+380
+00:34:53,400 --> 00:35:00,020
+مايصير مشاكل وعادة قد حُكّمهوكذا المشاقة تجلب
+
+381
+00:35:00,020 --> 00:35:04,260
+التيسيرة في الشرق والدين اللي عايش كل ما ضاقت
+
+382
+00:35:04,260 --> 00:35:10,720
+انفرجت والله أنا مريض كنت تصلي مطلوب منك تقوم تسير
+
+383
+00:35:10,720 --> 00:35:16,380
+تقعد تقعد كنت كذا تعمل كذا كل ما هناك مشاقة من فضل
+
+384
+00:35:16,380 --> 00:35:23,500
+الله علينا جعلنا تيسير والشك لا تنقض به متيقنا
+
+385
+00:35:23,500 --> 00:35:31,250
+يعني الشك اليقين يغلب الشكماشي فإذا أنا والله
+
+386
+00:35:31,250 --> 00:35:37,710
+اتوضيت شكيت أنا متأكد إن اتوضيت وشكيت إن أنا نقطت
+
+387
+00:35:37,710 --> 00:35:41,410
+الوضوء ولا ما قطتش إذا مش متأكد إن أنا نقطت الوضوء
+
+388
+00:35:41,410 --> 00:35:46,010
+خلاص وضوء جاهز كامل وغض النظر ما يوثوث في الواحد
+
+389
+00:35:46,010 --> 00:35:51,130
+ده حالة وقضية إنما الأعمال بالنيات وهذا من كبار
+
+390
+00:35:51,130 --> 00:35:55,710
+الأحاديث وعليها أشياء كثيرة إنه النية في العمل هي
+
+391
+00:35:55,710 --> 00:36:01,820
+الأساسولا قصد أخلص إن أردت أجورة اللي هي مبدأ أو
+
+392
+00:36:01,820 --> 00:36:06,820
+قاعدة إنما الأعمال بنفسها فهذه حقيقة يعني الجانب
+
+393
+00:36:06,820 --> 00:36:11,080
+اللي ما حد يعني أردت أوضيحه بزيادة عن ما ذُكر في
+
+394
+00:36:11,080 --> 00:36:16,400
+الكتاب والكتاب بيركز على ال effects تبعات
+
+395
+00:36:16,400 --> 00:36:23,740
+الأخلاقيات الطبية للدراسة الوراطية علم الوراطة
+
+396
+00:36:23,740 --> 00:36:28,860
+وعلم ال genomics وغيرها من الأشياء العاديةفبعد هذه
+
+397
+00:36:28,860 --> 00:36:32,600
+المقدمة يعني
+
+398
+00:36:32,600 --> 00:36:35,640
+في
+
+399
+00:36:35,640 --> 00:36:41,420
+جزء أنا بعتبر أنه مهم جدا أيضا من ناحية كتابكم
+
+400
+00:36:41,420 --> 00:36:48,320
+قضية إن هناك أربع مبادئ تحكم أخلاقيات التعامل مع
+
+401
+00:36:48,320 --> 00:36:52,860
+الوراتة وعلم الوراتة وقرصات الوراتة وأمراض الوراتة
+
+402
+00:36:52,860 --> 00:37:01,760
+وغيرهاالمبادئ هذه أولاً وطبعاً هتشوفها في يعني من
+
+403
+00:37:01,760 --> 00:37:08,760
+مبادئ سواء حقوق الإنسان العالمية حقوق الأبحاث
+
+404
+00:37:08,760 --> 00:37:13,120
+وأخلاقيات الأبحاث وغيرها من قسم الطبيب وغيرها
+
+405
+00:37:13,120 --> 00:37:18,460
+وغيرها أولاً يعني هناك أربع مبادئ أولاً Respect
+
+406
+00:37:18,460 --> 00:37:22,200
+for individual autonomySafeguarding an
+
+407
+00:37:22,200 --> 00:37:25,280
+individual's right to control his or her medical
+
+408
+00:37:25,280 --> 00:37:30,380
+care and medical information free of coercion يعني
+
+409
+00:37:30,380 --> 00:37:37,520
+أنه أنت مطالب بالمحافظة على استقلالية الفرد الذي
+
+410
+00:37:37,520 --> 00:37:43,040
+أمامك بالذات يعني هنا إحنا بيحط حريتك كما يتقال في
+
+411
+00:37:43,040 --> 00:37:46,760
+الأمثلة تنتهي عندما تبدأ حرية الآخرين
+
+412
+00:37:49,430 --> 00:37:59,410
+فالإنسان حر ويعني بأموره الشخصية ماشي وبالذات في
+
+413
+00:37:59,410 --> 00:38:06,270
+جسده ما تستطيع تجبره أو تتعدى على حريته وعلى
+
+414
+00:38:06,270 --> 00:38:13,690
+استقلاليته في قراراته لأن كل إنسان له مبادئ وله
+
+415
+00:38:13,690 --> 00:38:21,350
+يعني ما يعتبره ثمين لديهحق كل واحد كما أنت ترغب
+
+416
+00:38:21,350 --> 00:38:25,630
+يعني عامل الناس كما تحب أن يعاملوه لا تريد منهم
+
+417
+00:38:25,630 --> 00:38:33,710
+يعني أنه يجبروك على شيء أنت لا ترغبه، ناشي؟ فالحق
+
+418
+00:38:33,710 --> 00:38:38,170
+الإنسان في التصرف بجسمه، حق الإنسان يعني هذه قضية
+
+419
+00:38:38,170 --> 00:38:43,700
+إنه أنا جسمي ملكي، لأ مش ملكك للبيعبس أنا اللي
+
+420
+00:38:43,700 --> 00:38:48,100
+بتتصرف فيه ولاجب أنه يعني لما أي مريض يدخل
+
+421
+00:38:48,100 --> 00:38:52,960
+المستشفى الأصل يوقّع تفويت للمستشفى خطيه بس إذا
+
+422
+00:38:52,960 --> 00:38:57,200
+بده عملية لازم يوقّع إنه موافق على العملية إذا
+
+423
+00:38:57,200 --> 00:39:01,780
+الإنسان مابدوش وافق لأ مابتجبره تجبره وإذا بتعرف
+
+424
+00:39:01,780 --> 00:39:06,960
+إن الإنسان عنده يعني مفاهيم معينة في حقوقه بشكل
+
+425
+00:39:06,960 --> 00:39:14,300
+معين لأ بدك تطبقها حتى لو بموتيعني من الأمثل
+
+426
+00:39:14,300 --> 00:39:19,280
+المشهورة في طائفة من المسيحيين إيه بيسموهم شهود
+
+427
+00:39:19,280 --> 00:39:23,720
+يهوة باللغة العربية Jehovah Witnesses باللغة
+
+428
+00:39:23,720 --> 00:39:30,760
+الإنجليزية هذولة ناس مجموعة بصراحة لطيفين جدا
+
+429
+00:39:30,760 --> 00:39:36,420
+ومتدينين والله يهديهم إنه حد يشرح لهم الإسلام بشكل
+
+430
+00:39:36,420 --> 00:39:42,770
+جيد هذولة عندهم نقل الدم والأعباء حرفيعني كأن
+
+431
+00:39:42,770 --> 00:39:49,770
+تيجيك واحدة و لا تنزف و لا من حمل و لا تيجيك واحدة
+
+432
+00:39:49,770 --> 00:39:56,830
+منهم عندها مثلا دم ضعيف جدا و أنت اللي بتعرفه أنه
+
+433
+00:39:56,830 --> 00:40:02,610
+لازم تنقض حياتها بنقل الدم الله لو أنا ثبت عندي
+
+434
+00:40:02,610 --> 00:40:06,730
+أنه أنا بعالج إنسان هو من هذه الطائفة و هذه الشغل
+
+435
+00:40:06,730 --> 00:40:14,100
+عندهمهمة إنه لا يقبل نقل دم فخلاص، بدي التزن،
+
+436
+00:40:14,100 --> 00:40:19,660
+ماشي؟ respect for individual autonomy beneficence
+
+437
+00:40:19,660 --> 00:40:25,340
+حتى دورت مبارح عشان أجيب معناها بالعربي doing good
+
+438
+00:40:25,340 --> 00:40:32,120
+بمعنى الإحسان عمل الخير، اللي هي يعني أن تحسن
+
+439
+00:40:33,040 --> 00:40:37,060
+الإحسان والتقوى يعني أنك تراقب الله في أنك ماتز
+
+440
+00:40:37,060 --> 00:40:41,200
+بالإنسان اللي أمامك دايماً تعمل خير وطول قصدك تعمل
+
+441
+00:40:41,200 --> 00:40:47,640
+خير كقصد avoid يعني ال beneficience اللي هو
+
+442
+00:40:47,640 --> 00:40:54,040
+الإحسان باللغة العربية أن تكون محسن إحسان يعني مش
+
+443
+00:40:54,040 --> 00:40:58,500
+تكافئ الإنسان اللي أمامك لأنه عملك خير لأ أنت تبدأ
+
+444
+00:40:58,500 --> 00:41:04,640
+بأنك تعمل إشي خيروتكون تعمل عملية كافية الشغلة
+
+445
+00:41:04,640 --> 00:41:08,840
+الثالثة Avoidance of Maleficence اللي هو يعني
+
+446
+00:41:08,840 --> 00:41:12,680
+دايما بيقولوا القاعد الأولى في الطب First of all
+
+447
+00:41:12,680 --> 00:41:17,600
+do no harm باللغة الإنجليزية القانون الأول في الطب
+
+448
+00:41:17,600 --> 00:41:24,480
+لا يعني do no harm أي من حتى اللاتينية Primum Non
+
+449
+00:41:24,480 --> 00:41:30,020
+-Nucrilic نوسريلي اللي هي ذلك الله العظيميعني من
+
+450
+00:41:30,020 --> 00:41:34,520
+اللغة اللاتينية من «abocrat» وهي إنه لا تؤذي
+
+451
+00:41:34,520 --> 00:41:37,220
+الإنسان إذا ما تقدرتش تفيده على الأقل أنت ما
+
+452
+00:41:37,220 --> 00:41:43,920
+تتضروش ماشي إذا شاء يعني يعمل أو تدبّى إن هذا يسبب
+
+453
+00:41:43,920 --> 00:41:48,740
+ضرر، يسبب مرض وإذا عملت كذا راح يكون فيه مشكلة
+
+454
+00:41:48,740 --> 00:41:53,300
+المفروض إنك أنت ما تسويها الأمر الأخير أو القاعدة
+
+455
+00:41:53,300 --> 00:41:57,950
+الأخيرة هي قضية العدالة «justice»ensuring that all
+
+456
+00:41:57,950 --> 00:42:01,550
+individuals are treated equally and fairly هذه
+
+457
+00:42:01,550 --> 00:42:05,730
+مبادئ اسلامية يعني الرسول صلى الله عليه وسلم عندما
+
+458
+00:42:05,730 --> 00:42:12,050
+يعني يقول إنما أهلك من كان قبلكم كان إذا سرق
+
+459
+00:42:12,050 --> 00:42:16,570
+الشريف فيهم تركوه وإذا سرق فيهم الضعيف أقاموا عليه
+
+460
+00:42:16,570 --> 00:42:22,590
+الحد عندهم خيار وفقوس ويعني الناس أنواع ودرجات
+
+461
+00:42:22,590 --> 00:42:27,830
+وهذه يعني عيب في أي مجتمعالمفروض تكون يعني مبدأ
+
+462
+00:42:27,830 --> 00:42:34,670
+العدالة يعني أنا مثلا مرات كثيرة تصدف الواحد يجي
+
+463
+00:42:34,670 --> 00:42:40,330
+مرضى طبعا هذه القضايا الأخلاقية بد الواحد ياخد
+
+464
+00:42:40,330 --> 00:42:46,170
+مجمل القواعد كلها ويطبق عليها وهنشوف أنثى لأ أن
+
+465
+00:42:46,170 --> 00:42:50,510
+أحيانا القاعدتين بتضربوا وبالتالي بد الواحد يحكم
+
+466
+00:42:50,510 --> 00:42:57,070
+بينهم وربنا يهديه إلى الفرار الأفضلفالعدالة شغل
+
+467
+00:42:57,070 --> 00:43:06,110
+مطلوبة يعني مثلا كان عندنا يكون مشكلة أن أنت تطالب
+
+468
+00:43:06,110 --> 00:43:10,350
+بتقرير هل هي حالة طارية ولا مش طارية كنا لشغل
+
+469
+00:43:10,350 --> 00:43:15,230
+التأمين، ما تأمينيضطرون نروح على المريض اللي داخل
+
+470
+00:43:15,230 --> 00:43:18,750
+على التأمين في مستشفى خاص المفروض ما راح عليه
+
+471
+00:43:18,750 --> 00:43:25,250
+مريضة شو اسمه؟ نروح نشوف، والله قالولي كانوا
+
+472
+00:43:25,250 --> 00:43:29,790
+بالأول يقولولي إذا الإنسان ما كان بده يموت وفعلا
+
+473
+00:43:29,790 --> 00:43:37,210
+يعني فعلا خالص خالص، هاي كان ممكن يروح على مستشفى
+
+474
+00:43:37,210 --> 00:43:43,240
+الحكومي وبالتالي هي مش طارقةفنروح وفعلا كنت أتطبق
+
+475
+00:43:43,240 --> 00:43:48,000
+هذا الموضوع لو كان واحد جاي تجلطة أو حادث سير و
+
+476
+00:43:48,000 --> 00:43:53,700
+بيزموه على الفوارق في مستشفى وكان مستشفى خاص فخلاص
+
+477
+00:43:53,700 --> 00:43:59,380
+هي طارق لما واحد عنده مثلا حمّة صار لأسبوع ومتعبان
+
+478
+00:43:59,380 --> 00:44:03,020
+ومتعب كتير واخدوه على يعني كان عندهم قرار يعني
+
+479
+00:44:03,020 --> 00:44:07,180
+مجال يودوه على المستشفى كنت بقول هي مش طارق لحد ما
+
+480
+00:44:07,180 --> 00:44:14,740
+يوم من الأيامبجيني الله يرضى عليه كان وزير سابقا
+
+481
+00:44:14,740 --> 00:44:21,580
+يعني وكانت والدته فقاللي يا دكتور أنا هاي والدتي
+
+482
+00:44:21,580 --> 00:44:26,500
+وهي مؤمنة درجة أولى وطبعا والدة وزير وانا بدأ
+
+483
+00:44:26,500 --> 00:44:30,380
+أدخلها بالمكان اللي فلاني عجبك عجبك ماعجبك مش
+
+484
+00:44:30,380 --> 00:44:35,420
+ماعجبك نوصلها للملك ونمشيها غصبا عنها فاتصلت في
+
+485
+00:44:35,420 --> 00:44:38,920
+المسئول عني بقوله هيك هيك هيك الزلمة هذا بيحكيقال
+
+486
+00:44:38,920 --> 00:44:43,800
+يا عمي ما هو وزيره، هاي أمه، خلاص مشيها يعني مش
+
+487
+00:44:43,800 --> 00:44:48,260
+طارقة، مش طارقة، مشيها كنت حاضر، همشيها، بس والله
+
+488
+00:44:48,260 --> 00:44:52,520
+بعد ذلك كل إنسان عنده إشي بيقول تقوللي طارقة و لا
+
+489
+00:44:52,520 --> 00:44:55,280
+مش طارقة، مدام هي طلعت و راحت على الطوارق، هقولكم
+
+490
+00:44:55,280 --> 00:44:59,940
+إنه طارقة، فصرت أمشي كل الناس طارقة، لأنه بحب أعمل
+
+491
+00:44:59,940 --> 00:45:05,160
+الناس بعدالة، لكل الناس عندي سواسية، ما فيه خيار
+
+492
+00:45:05,160 --> 00:45:13,370
+تبكور، فهذه المبادئ الأساسيةالـ هناك يعني بالذات
+
+493
+00:45:13,370 --> 00:45:20,430
+أمور الوراثة مبادئ يعني أو نقاط معينة واضحة ضمن
+
+494
+00:45:20,430 --> 00:45:28,190
+المبادئ اللي حكيناها يعني هل يعني يوافق عليها
+
+495
+00:45:28,190 --> 00:45:33,110
+الواحد ولا لا يوافق فمثلا الـ prenatal diagnosis
+
+496
+00:45:33,110 --> 00:45:40,300
+مثلا قضية الـ non-disease traits أو sex مثلايعني
+
+497
+00:45:40,300 --> 00:45:43,840
+مثلًا من المشهور معروف يقول كيف عيب الدنيا بتتخربط
+
+498
+00:45:43,840 --> 00:45:50,740
+مثلًا في الهند في نقص شديد في النساء سبب بأي
+
+499
+00:45:50,740 --> 00:45:54,260
+مالوسونار من أول ما يبين العضايا التناثلية وإذا
+
+500
+00:45:54,260 --> 00:45:58,780
+أنت بتجهدوها يعني وإذا الموؤودة تسويلت هي دي
+
+501
+00:45:58,780 --> 00:46:03,080
+الموؤودة ماشي يصير الواحد مثلًا يشوف إذا بالذات
+
+502
+00:46:03,080 --> 00:46:07,770
+إذا الشغل مش مرضيعني أنا بدي ابني يطلع طويل، إذا
+
+503
+00:46:07,770 --> 00:46:11,630
+والله طلع قصير وإيه جدرت أدرسها إذا عرفت الـGene
+
+504
+00:46:11,630 --> 00:46:15,010
+على بقى مسئول عن الطيق الطول إذا واحد اللي قصير
+
+505
+00:46:15,010 --> 00:46:20,470
+بديه شيعة بيصير واحد يعني يتخذ إجراءات معينة
+
+506
+00:46:20,470 --> 00:46:24,730
+Testing of asymptomatic adults for genotypes that
+
+507
+00:46:24,730 --> 00:46:29,250
+predispose to late onset diseases يعني هل هذا جائز
+
+508
+00:46:29,250 --> 00:46:32,910
+مش جائز؟Testing asymptomatic children for
+
+509
+00:46:32,910 --> 00:46:36,550
+genotypes that predispose to adult-onset diseases
+
+510
+00:46:36,550 --> 00:46:41,470
+يعني بالذات إنت لما تعمل الفحص هذا، العيش بده كيار
+
+511
+00:46:41,910 --> 00:46:46,610
+ممكن أنا أبحث فيه ممكن واحد من نتاج الدراسات يكون
+
+512
+00:46:46,610 --> 00:46:52,070
+عنده معلومة معينة Secondary
+
+513
+00:46:52,070 --> 00:46:55,410
+findings and the right to not to know about
+
+514
+00:46:55,410 --> 00:46:59,230
+clearly deleterious mutations that will cause
+
+515
+00:46:59,230 --> 00:47:03,330
+disease that could be ameliorated or prevented if
+
+516
+00:47:03,330 --> 00:47:08,890
+the risks were known يعني أحياناً يعني في أشياء
+
+517
+00:47:09,530 --> 00:47:16,150
+يمكن تطلع بشكل ثانوي بس يعني هل حق الإنسان يعرفها؟
+
+518
+00:47:16,150 --> 00:47:22,850
+هل واجب عليها بلغه؟ هل مرات بتكون الأمور مشتبهة؟
+
+519
+00:47:22,850 --> 00:47:29,050
+privacy of genetic information يعني قضية سرية
+
+520
+00:47:29,050 --> 00:47:36,290
+المعلوماتسرية المعلومات من النواحي المهمة في الـ
+
+521
+00:47:36,290 --> 00:47:45,810
+Chats نحكي
+
+522
+00:47:45,810 --> 00:47:51,490
+بالاخر قضية
+
+523
+00:47:51,490 --> 00:48:01,710
+إنه إذا سويت تجربة هل الموضوع علني ولا سرييعني
+
+524
+00:48:01,710 --> 00:48:06,570
+مثلًا حكينا اللي راح نحكي مثلًا بالاخير الـGenetic
+
+525
+00:48:06,570 --> 00:48:14,160
+Screeningمن قضية برضه فيها Privacy يعني إذا أنا
+
+526
+00:48:14,160 --> 00:48:21,800
+والله عملت Screen وطلع إنسان إيجابي ممكن هناك مثلا
+
+527
+00:48:21,800 --> 00:48:26,940
+ناس بيرغبوش في أن حد يعرف عنهم في مثلا قد تكون نوع
+
+528
+00:48:26,940 --> 00:48:34,060
+من سبب الخجل، سبب التأثير، قلق واحنا مطلوب كدكتور
+
+529
+00:48:34,060 --> 00:48:39,860
+أنه نخفف قلق أي إنسان يعنيفهذا واجب لجميع المرضى
+
+530
+00:48:39,860 --> 00:48:47,980
+ماشي إذا الأمور فيها خطر على صحة المجتمع أو مرض
+
+531
+00:48:47,980 --> 00:48:53,040
+معدي وإذا أنا ما حجرت هذا الإنسان وما عمّمت على
+
+532
+00:48:53,040 --> 00:48:57,660
+إنه هذا مصاب لفترة معينة أنا منع أن أتعامل معه أنا
+
+533
+00:48:57,660 --> 00:49:01,880
+أسس زي الـ COVID هذا مشكلة إذا الواحد يقول كل واحد
+
+534
+00:49:01,880 --> 00:49:06,420
+أنا حقي أنا سريت معلومتي إذا أنا إيجابي إنك ما
+
+535
+00:49:06,420 --> 00:49:11,870
+تبلغوما تخلّي حد يعرف ويظل الواحد يشتم زي ما بده
+
+536
+00:49:11,870 --> 00:49:15,890
+ناشي؟ فالـ Privacy of genetic information أو
+
+537
+00:49:15,890 --> 00:49:19,490
+medical information Misuse of genetic information
+
+538
+00:49:19,490 --> 00:49:26,430
+يعني هذه أهم شيء مثلًا مرات في خيارات مثلًا جوانب
+
+539
+00:49:26,430 --> 00:49:32,870
+زي التأمين مثلًا توظيف كذا يعني احنا في أمريكا
+
+540
+00:49:32,870 --> 00:49:36,210
+المساواة بين العراق من المبادئ اللي عندهم مشكلة
+
+541
+00:49:36,210 --> 00:49:42,380
+فيهاوالله أنا بعلم للتوضيح اللون الإنسان هو شغل
+
+542
+00:49:42,380 --> 00:49:48,920
+واضح وأنا أسير يجيني أبيض أو يجيني أسود ماوضقوش
+
+543
+00:49:48,920 --> 00:49:54,520
+خصوصا إذا كان من الحكومة أو من الأشياء مش المؤسسات
+
+544
+00:49:54,520 --> 00:50:00,050
+الخاصة الخاصة إذا بالذاتيعني زي ما تقول شخصية أنا
+
+545
+00:50:00,050 --> 00:50:08,110
+والله حر والله إنسان يعني أسمر اللون وكذا بعتبره
+
+546
+00:50:08,110 --> 00:50:14,710
+مرعب بعتبره يعني عندي حق يعني هذا مالي وانا صاحب
+
+547
+00:50:14,710 --> 00:50:20,510
+المؤسسة وانا حر، بتكون مؤسسات عامة، بتكون حكومية،
+
+548
+00:50:20,510 --> 00:50:27,770
+بتكون كذا، لأ الأصل تكون النسب متساوييعني عشرة
+
+549
+00:50:27,770 --> 00:50:32,770
+بالمئة من الـ population سود أو فارقة إذا عشرة
+
+550
+00:50:32,770 --> 00:50:36,310
+بالمئة من الشرطة لازم تكون سود عشرة بالمئة
+
+551
+00:50:36,310 --> 00:50:41,250
+بالموظفي الفكومة لازم تكون سود ما بيصير مثلا كلهم
+
+552
+00:50:41,250 --> 00:50:45,310
+يكونوا بيض مايكونش ولا واحد أسود يعني فإيه قضية
+
+553
+00:50:45,310 --> 00:50:50,070
+التأمين، قضية التوظيف، قضية الحقوق والتعامل مع
+
+554
+00:50:50,070 --> 00:50:56,840
+الناس كلها فيها مشاكل أخلاقية ويلهايعني مبادئ
+
+555
+00:50:56,840 --> 00:51:02,560
+أخلاقية يجب أن ينتبه لها الواحدة فيعني هدولة يعني
+
+556
+00:51:02,560 --> 00:51:10,500
+كأمثلة من المناطق الأشياء اللي قد تكون هنا آخر الـ
+
+557
+00:51:10,500 --> 00:51:21,700
+slide حاطينه على إنه قصة إمرأة شو اسمه عمرها الآن
+
+558
+00:51:21,700 --> 00:51:25,930
+أربعين سنةعندها طلع بيّن Autosomal Dominant
+
+559
+00:51:25,930 --> 00:51:30,130
+Disorder يعني اللي حكيناها مثلا زي Alzheimer أسف
+
+560
+00:51:30,130 --> 00:51:34,050
+اللي هو Huntington's Chorea هذا مرض والله سيء
+
+561
+00:51:34,050 --> 00:51:38,990
+وبيقتل الإنسان بالأخير بس بيظهر وبيبدأ على عمره
+
+562
+00:51:38,990 --> 00:51:45,830
+متأخر فصدفة إنه اكتشفنا المرض عند هذه السيدة
+
+563
+00:51:45,830 --> 00:51:51,930
+ولقينا عندها mutation معين عندها بنت من زوجها
+
+564
+00:51:51,930 --> 00:51:57,980
+الأولوالبنت كمان عندها كأنه هاي الـ motivation
+
+565
+00:51:57,980 --> 00:52:06,760
+وعرفت عندها ابن أو أخ غير شقيق من رجل آخر بعد طلاق
+
+566
+00:52:06,760 --> 00:52:11,520
+الزوجين الأولين المرأة هاي اللي عمرها الآن أربعين
+
+567
+00:52:11,520 --> 00:52:18,540
+تزوجت زلمة تانية وجابت منه طفل ولد فالبنت والأم
+
+568
+00:52:19,390 --> 00:52:24,530
+عندهم الـ Genetic Mutation لـ Autosomal Dominant
+
+569
+00:52:24,530 --> 00:52:29,730
+وهي Serious وبتبين على عمر صغير هل واجب أن نبحث
+
+570
+00:52:29,730 --> 00:52:35,170
+أخوهم؟ اللي هو يعني الغير شقيق للأخت للبنت هذه
+
+571
+00:52:35,170 --> 00:52:40,270
+المصابة هل يجب أن نخبره عن هذا الموضوع ولا لأ؟
+
+572
+00:52:40,270 --> 00:52:45,510
+نتركه وما نقولهوش ولا كده؟ يعني إذا الواحد بقرا
+
+573
+00:52:45,510 --> 00:52:54,380
+هذا السيناريو مثالهل يجب أن نبلغه ولا ما نبلغوش؟
+
+574
+00:52:54,380 --> 00:52:59,260
+هو أنا بشرح طريقة تفكير المؤلفين إنه فيه أول شي
+
+575
+00:52:59,260 --> 00:53:09,440
+Clinical Question يعني القرار يعني في الفقه هناك
+
+576
+00:53:09,440 --> 00:53:17,920
+قاعدة تقول الحكم
+
+577
+00:53:17,920 --> 00:53:26,040
+على الشيءفرق ليه الفهم عن هذا الشيء يعني عشان هيك
+
+578
+00:53:26,040 --> 00:53:29,580
+كان فيه كثير من القضايا الطبية بالذات اللي كانت
+
+579
+00:53:29,580 --> 00:53:36,120
+فيها جوانب أخلاقية قانونية كده نجد القضاء وفقهاء
+
+580
+00:53:36,120 --> 00:53:40,840
+الشرق الحنيف بيقولك بيعملوا اجتماعات معنى كطباء
+
+581
+00:53:40,840 --> 00:53:47,600
+عشان يسألونا شو معنى كده شو معنى كده واللهبالذات
+
+582
+00:53:47,600 --> 00:53:51,800
+يعني، يعني بالذات في جوانب الأخلاقية إذا بنتبه
+
+583
+00:53:51,800 --> 00:53:58,220
+الواحد، نقطتين، بداية الحياة ونهاية الحياة، هدولة
+
+584
+00:53:58,220 --> 00:54:03,800
+بتلاقي عليهم جدال أخلاقي كبير، إذا مثلا الهولندا
+
+585
+00:54:03,800 --> 00:54:10,520
+لإنسان طبيعي، مش مكتئب، مش عنده depression، يقولك
+
+586
+00:54:10,520 --> 00:54:15,270
+والله أنا عندي سرطان أو عندي مرض لا يرجع شفاهيا
+
+587
+00:54:15,270 --> 00:54:19,090
+دكتور في عيد ميلادي الجاي اقضي عليّ واعطيني حقني
+
+588
+00:54:19,090 --> 00:54:26,610
+أموت وأكمل وأحرجوا جسمي وخلاص ملّيت من هذا التوتر
+
+589
+00:54:26,610 --> 00:54:32,810
+والقلق وكذا فيه في هولندا هذا بيحصلوا مقبول شرعيا
+
+590
+00:54:32,810 --> 00:54:36,470
+وأخلاقيا
+
+591
+00:54:36,470 --> 00:54:40,290
+ومجتمعيا يعني فيه غالبية أو ناس كبيرة بتقبل هذا
+
+592
+00:54:40,290 --> 00:54:45,200
+الاشياء بتلاقيهم كلهم بتلاقي الليفوالله أنا بعد
+
+593
+00:54:45,200 --> 00:54:51,400
+الشهرين أنا متفق مع الدكتور يخلص عليّ ومدام أنا مش
+
+594
+00:54:51,400 --> 00:54:58,440
+مبتعب وبالقانون وبيصير يعني باعطي الدكتور الحقنة
+
+595
+00:54:58,440 --> 00:55:06,840
+القاتلة والإنسان هذا بيكمل فالسيناريو هذا يعني
+
+596
+00:55:06,840 --> 00:55:15,860
+بيأكد على أولا إنه إحنا يجب علىمن يعني يتعامل مع
+
+597
+00:55:15,860 --> 00:55:21,720
+هذا الجانب ويريد أن يعطي حكمًا أخلاقيًا وانتباه
+
+598
+00:55:21,720 --> 00:55:27,240
+لهذا الجانب أول شيء يجب أن يكون فهما تمامًا جوانب
+
+599
+00:55:27,240 --> 00:55:31,740
+الطبية الصحية العلمية من هذا الحالة قضية
+
+600
+00:55:31,740 --> 00:55:35,220
+Penetrance of the Disorder يعني هل هناك احتمالية
+
+601
+00:55:35,220 --> 00:55:40,020
+أن هذا الفحث صحيح قال إنه في اشتباه يصير هذا
+
+602
+00:55:40,020 --> 00:55:47,140
+الحالةبس هل هي متأكدة؟ مافيش احتمالي إن الفحص هذا
+
+603
+00:55:47,140 --> 00:55:55,480
+مش بالقوة؟ هل هو lethal؟ هل هي كذا؟ طبعاً بيرجع
+
+604
+00:55:55,480 --> 00:55:59,820
+الأمر حسب القانون يعني في دول كتيرة القانون بيقولك
+
+605
+00:55:59,820 --> 00:56:05,460
+الإجهاد حلال ولا تستطيع يعني يعني يعاقب الطبيب
+
+606
+00:56:05,460 --> 00:56:09,860
+النسائي اللي ما بيسوي الإجهاد مثلا السبب إنه
+
+607
+00:56:09,860 --> 00:56:14,380
+بيقولكإذا المرأة هذه إن هي مقررة وهذا جزء من جسمها
+
+608
+00:56:14,380 --> 00:56:18,680
+مقررة بدها تخلص منه إذا أنت ما سويت لها يا طبيب
+
+609
+00:56:18,680 --> 00:56:23,340
+الإجهاض بطريقة سليمة علمياً أو طبياً أو صحياً
+
+610
+00:56:23,340 --> 00:56:28,220
+بتروح تسويها عند إنسان غير متخصص ومافيش نباطي
+
+611
+00:56:28,220 --> 00:56:32,660
+ومافيش كذا وبتتوفى لأنها سوّت الإجهاض بطريقة غير
+
+612
+00:56:32,660 --> 00:56:41,540
+صحية فهناك يعني موازين مختلفة فبالتالي يعنييجب أن
+
+613
+00:56:41,540 --> 00:56:48,820
+يكون هناك أسئلة للألم والطب تبع الحالة والـ
+
+614
+00:56:48,820 --> 00:56:54,780
+Counseling Questions ما هي الأسئلة التي يعني والـ
+
+615
+00:56:54,780 --> 00:57:00,840
+المتضادات من القواعد
+
+616
+00:57:00,840 --> 00:57:05,800
+الأخلاقية وبعدين الـ Legal و الـ Practical Issues
+
+617
+00:57:05,800 --> 00:57:12,310
+كموال جوارب القانونيةوالعملية لهذا الجانب فهذا
+
+618
+00:57:12,310 --> 00:57:19,030
+سيناريو مثال ويعني كما ذكرنا في جميع هذه النقاط إن
+
+619
+00:57:19,030 --> 00:57:24,570
+شاء الله ربنا يوفقنا ويهدينا ونتعلم يعني يصير واحد
+
+620
+00:57:24,570 --> 00:57:29,510
+زي ما بعرف التشريح و ال chemistry و ال
+
+621
+00:57:29,510 --> 00:57:33,590
+biochemistry و ال physiology يصير يعني كمانفي الـ
+
+622
+00:57:33,590 --> 00:57:40,810
+Ethics والمبادئ الأخلاقية والمبادئ القانونية
+
+623
+00:57:40,810 --> 00:57:45,790
+والمبادئ الاجتماعية في الطب كذلك مبارك الله فيكم
+
+624
+00:57:45,790 --> 00:57:52,750
+وبتوقف فيك إذا حد عنده أي سؤال أنا جاهز نقطة أخيرة
+
+625
+00:57:52,750 --> 00:57:57,290
+كأنه إنتبهت إنه حد بيسأل كيف راح يكون امتحان يوم
+
+626
+00:57:57,290 --> 00:58:01,090
+الجمعة برضه راح يكون MCQ زي المرة اللي حدت فسعاد
+
+627
+00:58:01,090 --> 00:58:08,350
+الشباترالأخيرة، نعم في
+
+628
+00:58:08,350 --> 00:58:11,650
+المحاضرة
+
+629
+00:58:11,650 --> 00:58:14,770
+اللي فاتت تقول بدا تريد شرح الـ Validity و الـ
+
+630
+00:58:14,770 --> 00:58:20,690
+Utility أعتقد شرحتهم بسرعة فبعت لك صورة فيها الـ
+
+631
+00:58:20,690 --> 00:58:23,810
+screenshot يعني إذا كنت فاعترضها و تريد شرحها
+
+632
+00:58:23,810 --> 00:58:31,010
+عسرية هاي ال screenshot بالنسبة لمحاضرة اليوم هاي
+
+633
+00:58:31,010 --> 00:58:38,760
+downloadده محاضرة اليوم فيها
+
+634
+00:58:38,760 --> 00:58:45,260
+سلعة محاضرة اليوم؟ لأ، المحاضرة اليوم بسيطة، الحمد
+
+635
+00:58:45,260 --> 00:58:53,660
+لله، وصغيرة أه، طيب، بس فيها مبادئ أساسية صحيح
+
+636
+00:58:53,660 --> 00:59:00,980
+يعني شوف، حط إن عندك يعني ده هيك بنحطها بمثال سريع
+
+637
+00:59:02,280 --> 00:59:08,420
+لما تأخذ أنساء مثلًا أنا ممكن تعمل شريح سكرين لها
+
+638
+00:59:08,420 --> 00:59:12,700
+بس يا دكتور نعم ممكن تعمل شريح سكرين لها بس عشان
+
+639
+00:59:12,700 --> 00:59:17,820
+تحدد فيه نقطة معينة فيها بتاعة التوضيح أشي النقطة
+
+640
+00:59:17,820 --> 00:59:26,980
+اللي بدك إياها أه وإن screen أو photo أه إيش
+
+641
+00:59:26,980 --> 00:59:32,420
+السؤال؟من عند قصة الـPPV والأرقام هذه اللي قدامي
+
+642
+00:59:32,420 --> 00:59:42,000
+اسمع، خدها كفاهم، الآن مثلا، مثلا، ناخد مثال
+
+643
+00:59:42,000 --> 00:59:51,560
+وحقيقة أنا باجي فحص للـHIV، الـHIV له سبب الـAIDS
+
+644
+00:59:51,560 --> 00:59:58,290
+وعندي فحص ممتاز إليه جدا، 99%Sensitive و99%
+
+645
+00:59:58,290 --> 01:00:07,250
+Specific صح؟ نفترض هيك معاي؟
+
+646
+01:00:07,250 --> 01:00:16,970
+أه تمام سيدي فإفرض إنه أنا هذا الفحص هو ممتاز 99%
+
+647
+01:00:16,970 --> 01:00:21,850
+جيت أخدته بالحالة الأولى ك population screening
+
+648
+01:00:21,850 --> 01:00:29,580
+يعني قررتمثلًا في الأردن احتمالية إنسان عنده HIV
+
+649
+01:00:29,580 --> 01:00:34,860
+مثلًا واحد بقدر يعني هيك تقديري واحد بالمائة ألف
+
+650
+01:00:34,860 --> 01:00:40,760
+ماشي يعني هيك يعني احنا تقريبًا من شخص من أول ما
+
+651
+01:00:40,760 --> 01:00:46,620
+بدأ الآن بقدر على مدى سنين كلها أوالي ألف بني آدم
+
+652
+01:00:46,620 --> 01:00:53,940
+تقريبًا فلما تخذها إنه هي شو الاحتمالية وجودهاواحد
+
+653
+01:00:53,940 --> 01:00:59,940
+بالألف وواحد بالـ 100 ألف مثلًا، نفترض هيك ماشي؟
+
+654
+01:00:59,940 --> 01:01:04,620
+ماشي معاه كريم؟
+
+655
+01:01:04,620 --> 01:01:11,980
+فلمّا أجي لهذا الفحص، هنا حاطينه كمثال حقيقي على
+
+656
+01:01:11,980 --> 01:01:19,150
+أرقام الـ APOE هذا عبارة عن فحص للـ Alzheimerبدل
+
+657
+01:01:19,150 --> 01:01:24,330
+الـ HIV اللي هنا بندرس الـ Alzheimer ماشي وبدل فحص
+
+658
+01:01:24,330 --> 01:01:28,310
+الـ Antibody أو شغل معين الـ Antigen بفحص هذا
+
+659
+01:01:28,310 --> 01:01:34,130
+الشيء بس الفكرة أنه الفحص أنا استخدمته لـ
+
+660
+01:01:34,130 --> 01:01:40,330
+Population Screen لحالة بنقصين نادرة فهنا مثلا
+
+661
+01:01:40,330 --> 01:01:45,670
+بالنسبة للـ HIV افرض واحد بالميت ألف لما تيجي تحط
+
+662
+01:01:45,670 --> 01:01:52,810
+الأرقاممقول فحص 99% sensitive 99% specific مافيش
+
+663
+01:01:52,810 --> 01:01:59,110
+عادة فحص بهذه الأرقام يعني 95، 90% ممتاز كتير أنا
+
+664
+01:01:59,110 --> 01:02:09,550
+بقولك خليه 99% شو نتيجة الأمر هذا أنه أنت راح صحيح
+
+665
+01:02:09,550 --> 01:02:18,110
+تقريبًا تصيد كل الناس اللي عندهم الـ HIV99% يعني
+
+666
+01:02:18,110 --> 01:02:26,490
+مثلًا الأردن شو اسمه الأردن 10 ملايين أقريبًا 99%
+
+667
+01:02:26,490 --> 01:02:33,150
+منهم لما نسوي الـ Population Screen راح يكون أو
+
+668
+01:02:33,150 --> 01:02:40,610
+افترضنا إنه الـ HIV واحد بالمائة ألف فالنتيجة كل
+
+669
+01:02:40,610 --> 01:02:49,670
+مليون فيهم عشرةوعندي عشر ملايين، بلاش 100 مليون،
+
+670
+01:02:49,670 --> 01:02:53,790
+واحد بالـ100 ألف خلّي الـHIV واحد بالعشر تلات،
+
+671
+01:02:53,790 --> 01:02:57,590
+نفترض أظن أنه أقرب لواحد بالـ100 ألف، بس افتراضًا
+
+672
+01:02:57,590 --> 01:03:02,190
+نفترض أنه واحد بالمليون، واحد بالعشر تلات فكل
+
+673
+01:03:02,190 --> 01:03:06,010
+مليون فيهم مية، وعشر ملايين يعني بيطلعوا عشر تلات
+
+674
+01:03:06,010 --> 01:03:10,510
+بني أدم أنا راح أصيد العشر تلات بني أدم، العشر
+
+675
+01:03:10,510 --> 01:03:16,340
+تلاتراح يكونوا تسعمية و تسعين تسعمية تسعتلاف و
+
+676
+01:03:16,340 --> 01:03:20,900
+تسعمية و تسعين واحد راح أصيبهم وعشرة مش راح أصيبهم
+
+677
+01:03:20,900 --> 01:03:27,680
+فأنا لقيت تسعمية و تسعتلاف و تسعمية واحد عندهم
+
+678
+01:03:27,680 --> 01:03:32,800
+المرض ستهم، بس شو اللي راح يصير؟ لإن أنا أعمل فحص
+
+679
+01:03:32,800 --> 01:03:39,780
+لكل الناس أنا لازم أفحصل عشر ملايين، العشر ملايين
+
+680
+01:03:40,620 --> 01:03:44,000
+التسعة يعني الغالبية العظمة منهم ما عندهمش تقريبًا
+
+681
+01:03:44,000 --> 01:03:48,500
+عشر ملايين يعني غير العشر تلافة دولة البقية التسع
+
+682
+01:03:48,500 --> 01:03:54,580
+ملايين، التسعمية، وتسعين ألف ماعندهمش المرض فلما
+
+683
+01:03:54,580 --> 01:03:58,940
+يكون الـ specificity برضه تسعة و تسعين بالمية
+
+684
+01:03:58,940 --> 01:04:06,000
+النتيجة إنه واحد بالمية من التسع ملايين راح يطلع
+
+685
+01:04:06,000 --> 01:04:15,140
+حواليتقريبًا بقدر مثلًا 1% من 9، 10 ملايين تقريبًا
+
+686
+01:04:15,140 --> 01:04:24,760
+راح يطلعوا تقريبًا شو اسمه؟ 100 ألف ماشي، 1% من 10
+
+687
+01:04:24,760 --> 01:04:31,760
+ملايين كام بتطلعوا هيك يحفظوه تقريبًا 10
+
+688
+01:04:31,760 --> 01:04:39,010
+ملايينواحد بالمية المية المليون في عشر تلات في
+
+689
+01:04:39,010 --> 01:04:45,630
+عشرة راح يطلع مائة ألف واحد صحيح صح راح يطلع إنه
+
+690
+01:04:45,630 --> 01:04:50,150
+إيجابي من الـ Negative False Positive يعني هو من
+
+691
+01:04:50,150 --> 01:04:52,890
+الـ Negative بالأصلي بس راح يطلع False Positive
+
+692
+01:04:52,890 --> 01:04:58,610
+راح يطلع بحدود أبو مائة ألف واحد فشو النتيجة صفتت؟
+
+693
+01:04:58,610 --> 01:05:03,920
+إنه لما يطلع عندك Test Positiveحقيقةً عشرة بالمية
+
+694
+01:05:03,920 --> 01:05:08,520
+بس من الـ positives هم الـ true positives وتسعين
+
+695
+01:05:08,520 --> 01:05:12,160
+بالمية من ال positives هم كانوا false positives
+
+696
+01:05:12,160 --> 01:05:15,920
+يعني هم negative فأنا في الحالة هذه ما استفدت من
+
+697
+01:05:15,920 --> 01:05:22,880
+الفحص ما بيصير، ما بيصيرش أسويها، ليش؟ لأن الفحص
+
+698
+01:05:22,880 --> 01:05:28,000
+هذا أنا بسويه في مجموعة احتمالية وجود المرض قليل
+
+699
+01:05:28,000 --> 01:05:35,320
+كتير وبالتالي أنابالتالي راح يكون الاستفادة منه مش
+
+700
+01:05:35,320 --> 01:05:42,020
+كتيرة واضح؟ بينما لو جبت هذا الـ Test وروحت مثلا
+
+701
+01:05:42,020 --> 01:05:48,400
+على سجن قلنا السجن فيه ناس تبعين مخدرات فيه ناس
+
+702
+01:05:48,400 --> 01:05:54,560
+بضربوا IV Drug Abuse فيه ناس عندهم سلوكيات أخلاقية
+
+703
+01:05:54,560 --> 01:06:03,520
+جنسية غير سوية مثلا ماشي والـ HIVبنسبته بتوقع أنها
+
+704
+01:06:03,520 --> 01:06:07,480
+أعلى أو أنا ممكن أكون درست وشوفت أنه عندهم نسبة
+
+705
+01:06:07,480 --> 01:06:13,520
+أعلى باستخدام هذا الفحص بيصير في هذه المجموعة كـ
+
+706
+01:06:13,520 --> 01:06:19,920
+Diagnostic Testing اللي .. اللي شو اسمه؟ اللي لما
+
+707
+01:06:19,920 --> 01:06:22,760
+يكون Positive بيكون فعلا Positive لما يكون
+
+708
+01:06:22,760 --> 01:06:27,720
+Negative فعلا بيكون Negative فاهم عليك كده؟ فهنا
+
+709
+01:06:27,720 --> 01:06:31,690
+انت ال testمرة استخدمته كـ Screening للـ
+
+710
+01:06:31,690 --> 01:06:37,810
+population والنتيجة راح تكون أنه أنت يعني ما راح
+
+711
+01:06:37,810 --> 01:06:43,730
+تستفيد فهم عليك كده؟ أما إذا بستخدمه كـ Diagnostic
+
+712
+01:06:43,730 --> 01:06:47,570
+Testing يعني شوف هنا، اقرأ معاه الـ Clinical
+
+713
+01:06:47,570 --> 01:06:53,350
+Validity في الحالة الأولى أنا جيت، شو سويت؟ جبت ال
+
+714
+01:06:53,350 --> 01:06:58,050
+population وكل الـ Asymptomatic Individuals Age 65
+
+715
+01:06:58,050 --> 01:07:04,650
+لـ 74جيت على مجتمع كل البني آدمين اللي من عمره 65
+
+716
+01:07:04,650 --> 01:07:11,430
+لـ 74 جيت وهم ماعندهم مش عارفين جيت فحصتهم أنا
+
+717
+01:07:11,430 --> 01:07:15,090
+بعرف الـ Population Prevalence of this condition
+
+718
+01:07:15,090 --> 01:07:21,410
+اللي هو Alzheimer Disease 3000% شايف عليا؟ اللي
+
+719
+01:07:21,410 --> 01:07:27,010
+لما تشوف الـ Test اللي انت مع أنه كويس هو بالأخير
+
+720
+01:07:27,010 --> 01:07:32,750
+مالوش قيمةالـ Positive Predictive Value لو هذه 6%
+
+721
+01:07:32,750 --> 01:07:38,150
+الـ Positive Predictive Value لـ الـ 23% يعني أنت
+
+722
+01:07:38,150 --> 01:07:43,930
+حتى الـ 23% معناته 77% من اللي راح يطلعوا Positive
+
+723
+01:07:43,930 --> 01:07:50,050
+هم False Positive هم Negative بالأصل ماشي؟
+
+724
+01:07:50,050 --> 01:07:56,030
+والملاحظة الثالثة كمان أنه لهذه الحالة و لهذه
+
+725
+01:07:56,030 --> 01:08:01,600
+المرض مافي إيش تسويهلو في إيش تسويه تقول ماشي بفحص
+
+726
+01:08:01,600 --> 01:08:06,740
+بظل بهمني يعني الـ Phenylketonuria ما هو under من
+
+727
+01:08:06,740 --> 01:08:11,880
+3% أقل من 3% مع ذلك بنسويه لأنه في إيش تسويه بس
+
+728
+01:08:11,880 --> 01:08:18,240
+هنا مافيش يعني intervention أو علاج تقدر تسويه شو
+
+729
+01:08:18,240 --> 01:08:22,220
+راح تسبب؟ أنت راح تعمل psychological stress for
+
+730
+01:08:22,220 --> 01:08:26,700
+most people يعني كتير ناس هيطلع false positive و
+
+731
+01:08:26,700 --> 01:08:30,970
+negativeو False Positive وبالتالي راح تسوي له قلق
+
+732
+01:08:30,970 --> 01:08:37,570
+و اللي مرات عنده الـ Negative طلعت برتاح و ب .. ب
+
+733
+01:08:37,570 --> 01:08:41,030
+.. ب .. يعني ب .. ب .. بفرد جرين و أنا والله طلعت
+
+734
+01:08:41,030 --> 01:08:44,150
+Negative مش راح يصيبني هذا و أنت بتعطيه False
+
+735
+01:08:44,150 --> 01:08:50,530
+Reaction لأنه ممكن يكون غلط وإنما لو أنا جيت مثال
+
+736
+01:08:50,530 --> 01:08:57,770
+آخر أخدت اللي عمارهمبرضه 65 ل 74 بس عنده معراضة ال
+
+737
+01:08:57,770 --> 01:09:02,630
+dimension هدولة مجموعة ناس أجوا اشتكوا والله أنا
+
+738
+01:09:02,630 --> 01:09:06,390
+بنسأت والله أنا بحط ال issue و بعدين بنسأت وين
+
+739
+01:09:06,390 --> 01:09:11,590
+حطيته طلعت على السوق و بعدين ماعرفتش أرجع بيتي
+
+740
+01:09:11,590 --> 01:09:16,730
+والله أنا كذا يعني ناس عندهم مشاكلة ماشي واضح يا
+
+741
+01:09:16,730 --> 01:09:17,190
+كريم؟
+
+742
+01:09:19,940 --> 01:09:23,880
+- يا عزيزي، يا عزيزي، يا عزيزي، يا عزيزي، يا
+
+743
+01:09:23,880 --> 01:09:24,100
+عزيزي، يا عزيزي، يا عزيزي، يا عزيزي، يا عزيزي، يا
+
+744
+01:09:24,100 --> 01:09:27,360
+عزيزي، يا عزيزي، يا عزيزي، يا عزيزي، يا عزيزي، يا
+
+745
+01:09:27,360 --> 01:09:31,180
+عزيزي، يا عزيزي، يا عزيزي، يا عزيزي، يا عزيزي، يا
+
+746
+01:09:31,180 --> 01:09:35,400
+عزيزي، يا عزيزي، يا عزيزي، يا عزيزي، يا عزيزي، يا
+
+747
+01:09:35,400 --> 01:09:41,640
+عزيزي، يا عزيزي، يا عزيزي، يا عزيزي، يا عزيزي، يا
+
+748
+01:09:41,640 --> 01:09:49,930
+عزيزي، يا عزيزي، يا عزيزيتطلع عندهم ثلاث حقيقيين
+
+749
+01:09:49,930 --> 01:09:54,210
+واحد بس الكذب أو إذا الـ Combination التانية أنت
+
+750
+01:09:54,210 --> 01:10:00,950
+بتوصل 98% يعني من خمسين بني آدم تسعة و أربعين
+
+751
+01:10:00,950 --> 01:10:06,990
+بيكونوا حقيقيين فالفائدة تبع الـ Test بهذه الطريقة
+
+752
+01:10:06,990 --> 01:10:13,310
+بتكون الفائدة لهذه الـ Test في الطريقة إيش إنه لو
+
+753
+01:10:13,310 --> 01:10:21,910
+كان إنسان عندهالـ… عنده dementia حقيقية وبداية
+
+754
+01:10:21,910 --> 01:10:27,110
+عراض والـ Test طالع Negative فاروح بدور على إشي
+
+755
+01:10:27,110 --> 01:10:30,490
+ثاني هذا مش الـ Alzheimer اللي أنا ماقدرش أتويله
+
+756
+01:10:30,490 --> 01:10:35,630
+إشي لأ هذا مثلا عنده الغد الدراقية مضروبة والله
+
+757
+01:10:35,630 --> 01:10:42,390
+عنده نقص تروية من شرايين الدماغ عنده سبب آخر للـ
+
+758
+01:10:42,390 --> 01:10:47,190
+dementia فبالتاليلما نكون الحالي بهذه الطريقة
+
+759
+01:10:47,190 --> 01:10:52,870
+بيصير عندي Suspicion that other potentially
+
+760
+01:10:52,870 --> 01:10:57,150
+treatable cause بيكون، لو عنده Hypothyroidism
+
+761
+01:10:57,150 --> 01:11:00,750
+بيعطيه Thyroxine بيحسنه، بتروح، بيصير كويس، بتروح
+
+762
+01:11:00,750 --> 01:11:06,050
+هاي الشغل منه، واحد عنده مرض نفسي، اكتئاب، كذا،
+
+763
+01:11:06,050 --> 01:11:09,960
+بيعطيه دوة، بتحسن، بتروحفانت هنا بتصير تدور على
+
+764
+01:11:09,960 --> 01:11:14,120
+إشي ثاني لأنك إذا قلت إنه high Alzheimer خلاص،
+
+765
+01:11:14,120 --> 01:11:17,600
+مابتقدرش تسوي له إشي و produces unnecessary
+
+766
+01:11:17,600 --> 01:11:25,700
+testing فهذه الأهمية إنه الفحص ولو إن اتنينهم 99%
+
+767
+01:11:25,700 --> 01:11:32,200
+sensitive و specific، شوه أهمية وين تبقى بسويها؟
+
+768
+01:11:32,200 --> 01:11:35,400
+ففيه Clinical Validity و Clinical Utility يعني
+
+769
+01:11:36,300 --> 01:11:40,700
+استفادة ومن وين هو valid يعني الـ «تست» هذا للـ
+
+770
+01:11:40,700 --> 01:11:44,220
+population screening غلط، ما بيصير استويت، مش يقول
+
+771
+01:11:44,220 --> 01:11:47,140
+أنا عندها الـ «تست» يلّا كل واحد عنده، خلاص بعمله
+
+772
+01:11:47,140 --> 01:11:51,860
+يا وصير أخبص، فاهم عليك؟ إن شاء الله أنه يكون حق
+
+773
+01:11:51,860 --> 01:11:55,440
+–طبعا، يعني القصد إنه الـ «symptoms» أو الـ
+
+774
+01:11:55,440 --> 01:11:57,360
+«diagnosis» ممكن يعمل «reduce» للـ «general
+
+775
+01:11:57,360 --> 01:12:01,780
+population» ويسهلك المنطق الفوصات؟ –لأ، بدك تقول
+
+776
+01:12:01,780 --> 01:12:09,070
+إنه، بدك تقول if not، هذا الـ«test»بهاي النسب لاجب
+
+777
+01:12:09,070 --> 01:12:13,650
+عمله عند وجود الأعراض إذا مافيش أعراض بصيرش أسوي
+
+778
+01:12:13,650 --> 01:12:20,690
+ماشي يعني مش واحد لأنه قلقام هيك والله أنا خايف
+
+779
+01:12:20,690 --> 01:12:24,690
+عند الـ Alzheimer ولا ماعنديش تعالي أعمل هذا ال
+
+780
+01:12:24,690 --> 01:12:29,170
+test موجود عندنا خليني نعمله لأ إذا ماعندكش المرض
+
+781
+01:12:29,170 --> 01:12:33,780
+من قبل راح تدخل حالك في دوامةوتصير تعمل فعصات
+
+782
+01:12:33,780 --> 01:12:37,260
+وتقلق من أشياء و هو بالأخير بيطلع غلط أما لو في
+
+783
+01:12:37,260 --> 01:12:41,600
+أعراف أه لازم تعملها بكتير إله قيمة أكبر وإله
+
+784
+01:12:41,600 --> 01:12:47,320
+أهمية وإله validity يعني valid يعني سليم أو مظبوط
+
+785
+01:12:47,320 --> 01:12:50,060
+أنك تعمله هيك أو صحيح أنك تعمله
+
+786
+01:12:52,600 --> 01:12:54,140
+- تمام، كنت أتكلم على هذا الأمر في الأخترار.
+-تقول
+
+787
+01:12:54,140 --> 01:12:56,920
+على إنك كنت تحصل على هذا، ولا كنت يعني، بس أتأمل
+
+788
+01:12:56,920 --> 01:13:03,080
+إنه واضح يعني، هي الفكرة إنه من ال .. إذا لو أنت
+
+789
+01:13:03,080 --> 01:13:08,440
+فاهمان الـPrevalence تبع الـDisease بالـPopulation
+
+790
+01:13:08,440 --> 01:13:14,140
+دوره في الـSensitivity والـSpecificity إذا بسوي
+
+791
+01:13:14,140 --> 01:13:18,260
+أنا Screening، بدي إياه Sensitive، أنا إذا بسوي
+
+792
+01:13:18,260 --> 01:13:24,160
+إشي Screening،بدي يا عشان أصيب كل الناس اللي عندهم
+
+793
+01:13:24,160 --> 01:13:28,520
+المرض هذا بيهمني فيه بس ممكن في الحالة هذه راح
+
+794
+01:13:28,520 --> 01:13:32,920
+أصيب ناس ماعندهم مش المرض فبدي بعدها أسوي specific
+
+795
+01:13:32,920 --> 01:13:37,500
+test اللي هو إنه بتأكد إنه ماعندوش مرض، ماعندوش
+
+796
+01:13:37,500 --> 01:13:41,100
+المرض يعني بدك تسويها بالـ two steps في هذا
+
+797
+01:13:41,100 --> 01:13:46,480
+الطريق، أه ماشي؟ يا طيب يا عزيزي يا دكتور الله
+
+798
+01:13:46,480 --> 01:13:51,840
+يحييكفي إذا في أي أسئلة ثانية إن شاء الله خير أنا
+
+799
+01:13:51,840 --> 01:13:56,580
+بظن الإمتحان راح يكون MCQ نفس الـ quiz الأولان
+
+800
+01:13:56,580 --> 01:14:01,620
+ونفس ال midterm بنفس الطريقة الله يوفقكم وشدحانكم
+
+801
+01:14:01,620 --> 01:14:05,900
+نراكم على خير دكتور يعني يعني إمتحان يوم الجمعة إن
+
+802
+01:14:05,900 --> 01:14:11,220
+شاء الله هيكون فيه أسئلة U word دي ليش؟ ولا بس
+
+803
+01:14:11,220 --> 01:14:16,600
+أسئلة MCQ قصيرة انت شو مشكلتك؟ادرس الفنتين، آه
+
+804
+01:14:16,600 --> 01:14:21,780
+يمكن تطلع هون، يمكن تطلع هون، ماشي، تضاركوا تفو
+
+805
+01:14:21,780 --> 01:14:24,420
+الدورة على .. حاضر يا دكتور، حاضر، ماشي، الله
+
+806
+01:14:24,420 --> 01:14:29,520
+يوفركم يعطيك العفو يا دكتور، مع السلامة، مع
+
+807
+01:14:29,520 --> 01:14:34,700
+السلامة، يالا نشوفكم على خير، بكرا المساء بودي لك
+
+808
+01:14:34,700 --> 01:14:38,520
+الأسئلة يا دكتور، يعطيك العفو يا دكتور، سلام عليكم
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/J6cZgtP3lRU_postprocess.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/J6cZgtP3lRU_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..4d3ef1133b0d8c226eabe82345a2cf014d88bcde
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/J6cZgtP3lRU_postprocess.srt
@@ -0,0 +1,3956 @@
+1
+00:00:00,000 --> 00:00:08,060
+أربعة ‏so far ‏طيب احنا المحاضرة بتتسجل ‏وإن شاء
+
+2
+00:00:08,060 --> 00:00:13,520
+الله يعني بالنسبة
+
+3
+00:00:13,520 --> 00:00:21,540
+لكم نبدأ ‏وبالنسبة لزي ما حكينا كل مرة ‏أول شيء ده
+
+4
+00:00:21,540 --> 00:00:28,220
+حد عنده أي أسئلة يعنيمراجعات كيف صلّح الكمبيوتر
+
+5
+00:00:28,220 --> 00:00:31,440
+وإن أنا غلطت وإن كان قصدي هيك أو مش قصدي هيك، فما
+
+6
+00:00:31,440 --> 00:00:38,880
+تتراجعي، فبتجننوك الطلاب وبرضوش وبتضيع الوقت أحنا
+
+7
+00:00:38,880 --> 00:00:44,000
+المهم أن الواحد يستفيد ويكون يعني حتى بالنسبة
+
+8
+00:00:44,000 --> 00:00:49,220
+للسؤال فاهم ليش هي صح ليش هي غلط المهم الفهم، بغض
+
+9
+00:00:49,220 --> 00:00:53,200
+النظر عن العلامة يعني العلامة مش مهم كتير، الله
+
+10
+00:00:53,200 --> 00:01:01,100
+أعينفي أسئلة يا دكتور أحمد؟ لأ، بخصوص المادة لا
+
+11
+00:01:01,100 --> 00:01:09,000
+لسه طيب إن شاء الله اليوم راح نتكلم عن موضوع
+
+12
+00:01:09,000 --> 00:01:14,200
+السرطانات أو الـ Cancer Genetics وGenomics بصراحة
+
+13
+00:01:14,200 --> 00:01:21,140
+يعني فيه ثلاث سلايدات مهمات جداً عشان يعني تبين
+
+14
+00:01:21,140 --> 00:01:22,720
+مفاهيم معينة
+
+15
+00:01:27,780 --> 00:01:33,160
+والدراسة أو يعني محاولة الدراسة هتكون على نوعين
+
+16
+00:01:33,160 --> 00:01:37,360
+اللي هم الـ Genetics والـ Genomics يعني لنشوف شو
+
+17
+00:01:37,360 --> 00:01:41,900
+دور هاي وهاي وكيف نشتغل فيها وشو اللي بيكون موجود
+
+18
+00:01:41,900 --> 00:01:50,100
+الـ Cancer اللي هي الأورام أو الورم يعني is a big
+
+19
+00:01:50,100 --> 00:01:56,280
+concept مفهوم كبير في الطبوحالات كثيرة ومن أهم
+
+20
+00:01:56,280 --> 00:02:03,120
+الأمراض اللي بتسبب وفيات ومن أهم الأمراض اللي يعني
+
+21
+00:02:03,120 --> 00:02:09,880
+بتتم دراستها وفي صعوبة في معالجتها والميزة
+
+22
+00:02:09,880 --> 00:02:16,100
+الأساسية فيها أن التسبب فيها معقد جداًوإن المناعة
+
+23
+00:02:16,100 --> 00:02:19,720
+اللي أنا من نفس خلايا الجسم ما بتقدر تقاومها يعني
+
+24
+00:02:19,720 --> 00:02:23,560
+it is highly complex in etiology الـ etiology
+
+25
+00:02:23,560 --> 00:02:29,160
+تبعتها تسبب فيها عادة multifactorial with so many
+
+26
+00:02:29,160 --> 00:02:34,420
+other components وأكثر من خلل معين بيصير بس واضح
+
+27
+00:02:34,420 --> 00:02:38,060
+إن الجينات والوراثة اللي دخل فيها والمناعة اللي
+
+28
+00:02:38,060 --> 00:02:47,050
+دخل فيها وفيه يعني مفاهيم كثيرةالورم هي يعني اللي
+
+29
+00:02:47,050 --> 00:02:50,910
+هي الـ Abnormal cells is like a mass يعني بالأخير
+
+30
+00:02:50,910 --> 00:02:56,590
+ورم يعني كتلة هيكي فحتى تصير كتلة يعني الواحد لازم
+
+31
+00:02:56,590 --> 00:03:01,730
+يتذكر إنه راح يكون في الغالب نمو غير طبيعي يعني
+
+32
+00:03:01,730 --> 00:03:09,020
+خلايا تتكاثر بشكل غير طبيعي زيادة عن اللزومفهذا قد
+
+33
+00:03:09,020 --> 00:03:13,700
+يكون إيتيولوجيا ويكون سبب بس كمان في أحيانا بتكون
+
+34
+00:03:13,700 --> 00:03:18,160
+إن الخلايا بتموتش بالشكل السريع يعني زي ما ممكن
+
+35
+00:03:18,160 --> 00:03:22,700
+تكون increased cell division as a cause of the
+
+36
+00:03:22,700 --> 00:03:31,180
+tumor formation ممكن decreased apoptosisبالعكس من
+
+37
+00:03:31,180 --> 00:03:35,600
+الجهة التانية بيكون أحيانًا هو السبب يعني بس
+
+38
+00:03:35,600 --> 00:03:41,880
+بالأخير يعني بنعتبر abnormal cell cycle الـ
+
+39
+00:03:41,880 --> 00:03:47,680
+cancers اللي هم two other major behavior problems
+
+40
+00:03:47,680 --> 00:03:56,560
+الخلايا الطبيعية لما تشوف خلية مش شابهة لها يعني
+
+41
+00:03:56,560 --> 00:03:59,960
+لو جبت بتري دش وحطيت شوية خلايا
+
+42
+00:04:11,660 --> 00:04:17,440
+الخلايا اللي من نفس النوع لما انتصل جنب بعض بتوقف
+
+43
+00:04:17,440 --> 00:04:21,140
+و الـ cell membrane تبعها بيبطل يتحرك و هذا بيسموه
+
+44
+00:04:21,140 --> 00:04:25,140
+contact inhibition فالـ cancer cells they don't
+
+45
+00:04:25,140 --> 00:04:32,470
+have contact inhibition they keep movingيعني
+
+46
+00:04:32,470 --> 00:04:38,490
+الوصول إلى موقع مستقبل المعانات يعني كثير من
+
+47
+00:04:38,490 --> 00:04:42,810
+الخلايا الثانية اللي بتكون محترمة هيكي و بس تصل
+
+48
+00:04:42,810 --> 00:04:46,030
+مكان معين بتوقف عنده، ما عدا الخلايا السرطانية
+
+49
+00:04:46,030 --> 00:04:50,110
+الخلايا السرطانية، هم يفقدون انهيبشتهم بالتواصل
+
+50
+00:04:50,110 --> 00:04:56,350
+وهم لديهم تندنسية لـMetastasis لـMetastasize نتيجة
+
+51
+00:04:56,350 --> 00:05:01,320
+الانتشار هذا، بتلاقيها بتروح لماكن بعيدةفالـ
+
+52
+00:05:01,320 --> 00:05:06,320
+«سلايد» الأول اللي حاطيه لكم إياه بيبين فيها كيف
+
+53
+00:05:06,320 --> 00:05:11,660
+مراحل النشوء
+
+54
+00:05:11,660 --> 00:05:16,540
+وحدوث مشكلة السرطان طبعاً المشكلة حتى لو ظهرت في
+
+55
+00:05:16,540 --> 00:05:20,860
+لحظة معينة عند إنسان بتكون صالة زمان وهي ماشية
+
+56
+00:05:20,860 --> 00:05:27,220
+وبتتكون وبتمر بـ stages كتير قبل حتى ما نشوفهاهذه
+
+57
+00:05:27,220 --> 00:05:30,900
+مثلًا الـ Normal Epithelium سواء بالـ GI Tract أو
+
+58
+00:05:30,900 --> 00:05:36,900
+في أي محل نجد أن هناك الـ Normal Epithelium اللي
+
+59
+00:05:36,900 --> 00:05:41,160
+موجود والـ Sub-epithelial areas اللي من الـ
+
+60
+00:05:41,160 --> 00:05:45,120
+Appropriate ويكون مثلًا فيه Lymphatic vessels
+
+61
+00:05:45,120 --> 00:05:50,300
+وBlood vessels والأشياء عادية هناالمشكلة الحرارية
+
+62
+00:05:50,300 --> 00:05:55,760
+تبدأ بـExcessive proliferation of abnormal cells
+
+63
+00:05:55,760 --> 00:06:00,940
+بيبدأ في المنطقة الميكوزالية وبتكون في الـ Stage
+
+64
+00:06:00,940 --> 00:06:06,480
+الأولى بهذا الشكل لأنهم فقدوا انهياب الاتصال
+
+65
+00:06:06,480 --> 00:06:15,410
+وبدأوا بالـMetastasizeتتخرج من
+
+66
+00:06:15,410 --> 00:06:19,770
+محيطها، تتخرج من مكانها، تتدخل إلى الـsub-mucosal
+
+67
+00:06:19,770 --> 00:06:23,350
+area يعني احنا كثير مثلا في أشياء في الجلد أو في
+
+68
+00:06:23,350 --> 00:06:27,650
+الـGI tract لوين خازقة ولوين واصلة، هذا إشي مهم
+
+69
+00:06:27,650 --> 00:06:31,830
+للـstage وشو اللي نحتاج نعمله للـtreatment
+
+70
+00:06:31,830 --> 00:06:36,590
+والـmanagement ولكذافتبدأ بتخرق بالـ Surrounding
+
+71
+00:06:36,590 --> 00:06:41,200
+Tissues، وبعدين They Extend Into Localالـ lymph
+
+72
+00:06:41,200 --> 00:06:46,700
+nodes وبعدين بيصير إذا بينتشر بالدم بيصير يقدر
+
+73
+00:06:46,700 --> 00:06:49,760
+يروح على distant metastases مثل الـ liver، الـ
+
+74
+00:06:49,760 --> 00:06:53,360
+kidneys، الـ lungs يعني الـ lungs number one لأن
+
+75
+00:06:53,360 --> 00:06:57,640
+كل الـ circulation بالأخير لازم تمر بالـ lungs at
+
+76
+00:06:57,640 --> 00:07:01,880
+some stage to oxygenate the hemoglobin فالـ lung
+
+77
+00:07:01,880 --> 00:07:05,940
+metastases، الـ liver، but any other organ they
+
+78
+00:07:05,940 --> 00:07:12,390
+can have metastasesهذه مرحلة عادية
+
+79
+00:07:12,390 --> 00:07:15,430
+في
+
+80
+00:07:15,430 --> 00:07:22,490
+الـ «تيومر»
+
+81
+00:07:22,490 --> 00:07:27,810
+أو الـ «كانسيروم» أو الـ «تيولوجيا» أو الـ
+
+82
+00:07:27,810 --> 00:07:33,350
+«جينيسيا» أو الـ «تيومر»الـ Stage الأولى يعني مرات
+
+83
+00:07:33,350 --> 00:07:39,730
+ممكن يسموها «Carcinoma in Situ» يعني لسه محصورة
+
+84
+00:07:39,730 --> 00:07:46,590
+ومش منتشرة وبعدين «Local Invasion» وبعدين «Frank
+
+85
+00:07:46,590 --> 00:07:50,250
+Invasion» و«Reaching the Regional Lymph Nodes»
+
+86
+00:07:50,250 --> 00:07:53,870
+وبعدين بيصير «Distant Metastasis» وهنا بيكون
+
+87
+00:07:53,870 --> 00:07:59,710
+الأمور يعني تقريبًا في الغالب انتهت يعنيالحالة
+
+88
+00:07:59,710 --> 00:08:10,390
+متقدمة والوضع سيء لما نأتي نشوف هذا الموضوع الآن
+
+89
+00:08:10,390 --> 00:08:13,290
+ستكون عملية عملية عملية عملية عملية عملية عملية
+
+90
+00:08:13,290 --> 00:08:14,050
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+91
+00:08:14,050 --> 00:08:17,450
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+92
+00:08:17,450 --> 00:08:17,470
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+93
+00:08:17,470 --> 00:08:17,730
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+94
+00:08:17,730 --> 00:08:19,150
+عملية
+
+95
+00:08:29,880 --> 00:08:40,360
+في النهاية، يعني فيه table أو فيه paragraph في box
+
+96
+00:08:40,360 --> 00:08:51,100
+حاطين فيه الـ biggest points بالنسبة
+
+97
+00:08:51,100 --> 00:08:58,920
+للـ cancer، their behavior is differentسيل سايكلهم
+
+98
+00:08:58,920 --> 00:09:06,820
+مختلفة إنهم يكتشفوا بروتينات جديدة ما نسميه مرات
+
+99
+00:09:06,820 --> 00:09:12,900
+تمور أنتيجين بيكونوا بروتينات جديدة أو شيء مختلف
+
+100
+00:09:12,900 --> 00:09:21,380
+فالـ tumor أو الـ driver genes
+
+101
+00:09:25,240 --> 00:09:29,640
+يعني وين الواحد إذا بده يروح يدور أو شوهي أنواع
+
+102
+00:09:29,640 --> 00:09:34,280
+الجينات اللي بتكون mutated in cancer بالاخر واحد
+
+103
+00:09:34,280 --> 00:09:41,360
+إنه it's mainly really about cell
+
+104
+00:09:41,360 --> 00:09:43,160
+cycle regulation
+
+105
+00:09:45,670 --> 00:09:48,310
+الـ….الـ….الـ…… الـ…… الـ…… الـ…… الـ…… الـ……
+
+106
+00:09:48,310 --> 00:09:48,730
+الـ…… الـ…… الـ…… الـ…… الـ…… الـ…… الـ…… الـ……
+
+107
+00:09:48,730 --> 00:09:49,370
+الـ…… الـ…… الـ…… الـ…… الـ…… الـ…… الـ…… الـ……
+
+108
+00:09:49,370 --> 00:09:54,030
+الـ…… الـ…… الـ…… الـ…… الـ…… الـ…… الـ…… الـ……
+
+109
+00:09:54,030 --> 00:10:06,730
+الـ…… الـ…… الـ…… الـ…… الـ……
+
+110
+00:10:06,730 --> 00:10:09,310
+الـ…
+
+111
+00:10:11,820 --> 00:10:19,880
+الخلية تبدأ تدخل الـ Cell Cycle
+
+112
+00:10:19,880 --> 00:10:23,280
+أو الـ Apoptosis تبدأ تدخل الـ Cell Cycle أو الـ
+
+113
+00:10:27,210 --> 00:10:34,010
+الـG1 والـG2 والـS-Phase والـM والكذا كلهم بيكونوا
+
+114
+00:10:34,010 --> 00:10:37,990
+بيكونوا بيكونوا بيكونوا بيكونوا بيكونوا بيكونوا
+
+115
+00:10:37,990 --> 00:10:38,850
+بيكونوا بيكونوا بيكونوا بيكونوا بيكونوا بيكونوا
+
+116
+00:10:38,850 --> 00:10:38,930
+بيكونوا بيكونوا بيكونوا بيكونوا بيكونوا بيكونوا
+
+117
+00:10:38,930 --> 00:10:38,990
+بيكونوا بيكونوا بيكونوا بيكونوا بيكونوا بيكونوا
+
+118
+00:10:38,990 --> 00:10:39,050
+بيكونوا بيكونوا بيكونوا بيكونوا بيكونوا بيكونوا
+
+119
+00:10:39,050 --> 00:10:56,470
+بيكونوا بي
+
+120
+00:11:02,000 --> 00:11:06,260
+بالنسبة للـ Cell Cycle وفيه Cell Proliferation
+
+121
+00:11:07,560 --> 00:11:12,500
+لانقسام الخلايا أو تكاثر الخلايا فيه لـSignal معين
+
+122
+00:11:12,500 --> 00:11:17,600
+إذا صار فيها mutation هنا ويكون فيها نوع من
+
+123
+00:11:17,600 --> 00:11:21,600
+الـSpecific effect on cellular proliferation فإذا
+
+124
+00:11:21,600 --> 00:11:26,880
+فيه Transcription factors إشي بيخلي certain gene
+
+125
+00:11:26,880 --> 00:11:33,220
+become transcribedممكن الـ Receptors for الـ
+
+126
+00:11:33,220 --> 00:11:36,900
+Transcription Factors اللي هم الـ Main Group هم
+
+127
+00:11:36,900 --> 00:11:40,160
+الـ Tyrosine Kinases الـ Tyrosine هو الـ Amino
+
+128
+00:11:40,160 --> 00:11:43,880
+Acid والـ Kinase هو اللي بيحط الفسفات على الـ
+
+129
+00:11:43,880 --> 00:11:48,440
+Tyrosineأو بيقعوا بيشيلوا منها الفوسفات مرات أخرى
+
+130
+00:11:48,440 --> 00:11:55,680
+فـTyrosine kinase هم مجموعات من طرابات إتصالية
+
+131
+00:11:55,680 --> 00:12:05,240
+لعديد من الهرمونات أو إتصالات من خارج الجسم لتصل
+
+132
+00:12:05,240 --> 00:12:08,410
+إلى الـNucleus ويسبب فيه الأفعالفيه الـ Growth
+
+133
+00:12:08,410 --> 00:12:12,030
+Factors، الـ Changes أو الـ Mutations الـ
+
+134
+00:12:12,030 --> 00:12:15,190
+Intracellular Other Type of كيناز اللي هم الـ
+
+135
+00:12:15,190 --> 00:12:18,590
+Serine، الـ Theriorinine اللي هم أنواع من الـ
+
+136
+00:12:18,590 --> 00:12:25,270
+Amino Acids كينازيز الـ PI-3 كينازيز اللي هم الـ
+
+137
+00:12:25,270 --> 00:12:33,470
+Phosphatidyl-Inostol-3 كيناز يعني إحنا في المناعة
+
+138
+00:12:34,130 --> 00:12:39,390
+في إذا بتنتبهوا أو انتبهتوا عليه فيه إيش اسمه في
+
+139
+00:12:39,390 --> 00:12:43,110
+الـSignal Transduction Topic فيه إيش بيسموه
+
+140
+00:12:43,110 --> 00:12:48,550
+الـJack والستاد الـJack اللي هو يعني إله اسم
+
+141
+00:12:48,550 --> 00:12:54,390
+«Genus Associated Kinase» إله اسم غريب بس بالنسبة
+
+142
+00:12:54,390 --> 00:12:57,910
+ل… يعني أستاد إلي كان يقول لي «Just another
+
+143
+00:12:57,910 --> 00:13:04,140
+kinase» ففي عندنا أنواع كثيرة من الـMoleculesالتي
+
+144
+00:13:04,140 --> 00:13:06,280
+تعمل على عملية عبارة عن عبارة عن عبارة عن عبارة عن
+
+145
+00:13:06,280 --> 00:13:08,840
+عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة
+
+146
+00:13:08,840 --> 00:13:09,980
+عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن
+
+147
+00:13:09,980 --> 00:13:13,680
+عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة
+
+148
+00:13:13,680 --> 00:13:15,920
+عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن
+
+149
+00:13:15,920 --> 00:13:16,700
+عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة
+
+150
+00:13:16,700 --> 00:13:17,480
+عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن
+
+151
+00:13:17,480 --> 00:13:24,520
+عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة
+
+152
+00:13:24,520 --> 00:13:29,510
+عنففيه كمان الـ G-Proteins والـ «G-Protein Coupled
+
+153
+00:13:29,510 --> 00:13:32,290
+Receptors» كمان هدولة اللي مدخل بالـ Signal
+
+154
+00:13:32,290 --> 00:13:38,710
+Transduction فيه هنا «M mammalian target of
+
+155
+00:13:38,710 --> 00:13:46,090
+rapamycin» هدولة الـ Signal Pathway كمان «Winet»
+
+156
+00:13:46,090 --> 00:13:50,510
+«B» «Beta» «Catenin signaling transcription
+
+157
+00:13:50,510 --> 00:13:57,760
+factors»حاطينهم مكررينها مرتين، هذا غلط إملائي أو
+
+158
+00:13:57,760 --> 00:14:01,700
+عدم انتباه من اللي حاطط، بس إن هناك أمثلة كثيرة
+
+159
+00:14:01,700 --> 00:14:07,080
+Differentiation and Lineage Survivalحكينا إحنا
+
+160
+00:14:07,080 --> 00:14:11,280
+هذولة يمكن الـ Jack و الـ Stat و هذولة مشتركات من
+
+161
+00:14:11,280 --> 00:14:16,060
+أكتر من نوع من الخلايا بس لازم يكون لكل نوع خلية
+
+162
+00:14:16,060 --> 00:14:21,040
+فيه specific transcription factor أو regulator for
+
+163
+00:14:21,040 --> 00:14:27,480
+each type of cell وفيه regulators of apoptosis الـ
+
+164
+00:14:27,480 --> 00:14:32,280
+other group of genes اللي هم global effects on the
+
+165
+00:14:32,280 --> 00:14:40,170
+genome and DNA integrity أوGene Expressionالمطلوب
+
+166
+00:14:40,170 --> 00:14:45,490
+أنه الـGenome Integrity اللي فيه DNA Repair
+
+167
+00:14:45,490 --> 00:14:48,550
+الـChromosomal
+
+168
+00:14:48,550 --> 00:14:51,670
+Segregation الـGenome and Gene Mutation Inhibition
+
+169
+00:14:51,670 --> 00:14:56,650
+يعني الـRegulation الـGene Expression with
+
+170
+00:14:56,650 --> 00:15:01,950
+Abnormal Metabolizing Effect يعني التأثيرات على
+
+171
+00:15:01,950 --> 00:15:06,630
+الـGene Expression اللي فيه Certain Epigenetic
+
+172
+00:15:06,630 --> 00:15:11,560
+Mutationفنتكلم عنهم بما فيه الـ «DNA Methylation»
+
+173
+00:15:11,560 --> 00:15:16,460
+أو «Hydroxyl Methylation» و«Histone Methylation»
+
+174
+00:15:16,460 --> 00:15:20,480
+أو «Demethylation» أو «Acetylation» «Nucleosome
+
+175
+00:15:20,480 --> 00:15:26,360
+Remodeling» «Chromatin Accessibility»
+
+176
+00:15:26,360 --> 00:15:30,360
+يعني سهولة الوصول لقطع معينة و«Compaction» لما
+
+177
+00:15:30,360 --> 00:15:34,120
+ينضغطوبالتالي ما يقدرش أي شيء يقرأ منها
+
+178
+00:15:34,120 --> 00:15:37,820
+الـDifferent levels of gene expression with
+
+179
+00:15:37,820 --> 00:15:41,980
+certain post-transcriptional alterations زي
+
+180
+00:15:41,980 --> 00:15:47,580
+التأثيرات على الـApparent RNA والـMicro-RNAs
+
+181
+00:15:47,580 --> 00:15:53,080
+وهدولة يعتبروا كمان من الـEpigenetic Control واللي
+
+182
+00:15:53,080 --> 00:15:56,300
+على الـGene Expression أو الـProtein Stability أو
+
+183
+00:15:56,300 --> 00:15:58,440
+Turnover هدولة
+
+184
+00:16:00,200 --> 00:16:05,640
+أمثلة على الـ «جينات» وأشياء اللي دخلت بالـ
+
+185
+00:16:05,640 --> 00:16:12,100
+«كانسورز» ويعني الحابين
+
+186
+00:16:12,100 --> 00:16:17,040
+هنا يفرقوهم لـ «جينات» بأفعال محددة على الـ
+
+187
+00:16:17,040 --> 00:16:21,400
+Cellular Proliferation أو الـ Apoptosis وعلى الـ
+
+188
+00:16:21,400 --> 00:16:23,860
+«جينوم» أو الـ DNA Integrity أو الـ Gene
+
+189
+00:16:23,860 --> 00:16:28,340
+Expression بالنوع الثاني في حد عنده سؤال؟
+
+190
+00:16:31,930 --> 00:16:35,090
+إذا كان هناك أي سؤال، يا دكتور أحمد، واقفني
+
+191
+00:16:35,090 --> 00:16:39,030
+وأخبرهم أن يسألوا ونرى إذا كان هناك أي شيء غير
+
+192
+00:16:39,030 --> 00:16:45,770
+واضح. الآن، عندما نأتي ونرى
+
+193
+00:16:45,770 --> 00:16:51,250
+كيف الوضع، لكي نرى أي أماكن في الغالب،في
+
+194
+00:16:51,250 --> 00:17:00,670
+الـCancers، أين هي الـAnomalies؟ أين هي التغييرات
+
+195
+00:17:00,670 --> 00:17:04,590
+المحددة؟ وحكينا
+
+196
+00:17:04,590 --> 00:17:09,550
+الملاحظة عن الموضوع هذا كما حكيت بالأول، إنه عادةً
+
+197
+00:17:09,550 --> 00:17:13,940
+كمplex، إنه عادةً أكتر من واحد فاكتورأكيد فيه الـ
+
+198
+00:17:13,940 --> 00:17:19,020
+Environmental Factors كثيرة زي مثلًا الـ
+
+199
+00:17:19,020 --> 00:17:22,860
+Radiation، الـ Chemicals زي الـ Smoking، الـ
+
+200
+00:17:22,860 --> 00:17:29,960
+Asbestos، الـ Drugs، الـ Viral Infections أو الـ
+
+201
+00:17:29,960 --> 00:17:33,360
+Infections in general ممكن يكون إليها دخل ففيها
+
+202
+00:17:33,360 --> 00:17:36,840
+أشياء كثيرة بتتدخل إنه بالأخير بيصير عندي الورم
+
+203
+00:17:36,840 --> 00:17:41,460
+اللي أنا بشوفه وبشوف الخلايا اللي بتشتغل بشكل غير
+
+204
+00:17:41,460 --> 00:17:51,770
+طبيعيالآن إذا شُفت أنا إيش الوضع بالنسبة لـ الـ
+
+205
+00:17:51,770 --> 00:17:58,790
+بالنسبة لو أطلع على إيش بيصير بالنسبة للـ Normal
+
+206
+00:17:58,790 --> 00:18:04,810
+Cell Behavior وكيف تشتغل، فأقول أنا بالأول عندي
+
+207
+00:18:04,810 --> 00:18:09,510
+The Whole Genome والـ Genome هذا Controlled، يعني
+
+208
+00:18:09,510 --> 00:18:13,990
+كل الخلايا لما تنقسمالـ DNA Replication لازم يكون
+
+209
+00:18:13,990 --> 00:18:20,130
+Perfect لازم يكون مية بالمية، مافيش نسبة خطأ وإذا
+
+210
+00:18:20,130 --> 00:18:22,630
+صار خطأ لازم فيه Mechanisms أو There are
+
+211
+00:18:22,630 --> 00:18:27,190
+Mechanisms for Repairوفي ND لازم عشان أعرف أنا
+
+212
+00:18:27,190 --> 00:18:31,570
+أسوي الـ Transcription لازم الـ Chromosome هتكون
+
+213
+00:18:31,570 --> 00:18:36,390
+Stable و able to segregate يعني لما تنقسم الخلية،
+
+214
+00:18:36,390 --> 00:18:41,410
+الانقسام يكون متساوي ونفس الـ Copy of the whole
+
+215
+00:18:41,410 --> 00:18:49,230
+genome is transferred to the daughter cells فلما
+
+216
+00:18:49,230 --> 00:18:54,030
+أنا أجي أعمل Gene Expressionأفتح الـ Transcription
+
+217
+00:18:54,030 --> 00:19:00,070
+و Translation لازم أفتح الـ Two Strands of DNA
+
+218
+00:19:00,070 --> 00:19:07,250
+يعني هو أصلا الـ DNA ملفوف، لف شديد زي طبّة إحبال
+
+219
+00:19:07,250 --> 00:19:13,550
+مربوطة كثير في شكل كرة و اللي بيخلّيه ثابت في هذا
+
+220
+00:19:13,550 --> 00:19:17,210
+الـ EC Structures حكينا هم الـ Histones الـ
+
+221
+00:19:17,210 --> 00:19:22,980
+Histones have to beعلى مجموعة جينات مستخدمة
+
+222
+00:19:22,980 --> 00:19:27,100
+للتواصل مع بعضها لازم الـ Histone في المنطقة اللي
+
+223
+00:19:27,100 --> 00:19:33,480
+فيها الجين المطلوب يتم تغييره بشكل بحيث أنه الـ
+
+224
+00:19:33,480 --> 00:19:37,600
+Chromatin والـ DNA يكون accessible للـ RNA
+
+225
+00:19:37,600 --> 00:19:41,640
+بوليماريز اللي راح من الـ DNA يعني يعمل عملية الـ
+
+226
+00:19:41,640 --> 00:19:46,520
+Transcription للـ DNAويعطيني الـ Gene Expression
+
+227
+00:19:46,520 --> 00:19:51,660
+اللي هو الـ Messenger RNA وبعدين الـ Messenger RNA
+
+228
+00:19:51,660 --> 00:19:57,500
+طبعاً بالأول RNA عادي كامل أو أولي، وبعدين بتصير
+
+229
+00:19:57,500 --> 00:20:05,940
+Splicing وبتكون الـ Messenger RNA المطلوب حتى يصير
+
+230
+00:20:05,940 --> 00:20:11,740
+الـ Gene Protein Expression فهذه هنا، بيصير عندي
+
+231
+00:20:11,740 --> 00:20:15,760
+Variation أنهالـ Copy Number وبكلها بتأثر على الـ
+
+232
+00:20:15,760 --> 00:20:24,360
+Translation و Transcription وبعدين Translation بعد
+
+233
+00:20:24,360 --> 00:20:30,660
+هيك الخلايا هذه بحاجة أن تصير أنها لها Cell Cycle
+
+234
+00:20:30,660 --> 00:20:35,560
+Control وControlled Proliferation يعني إشي قريب من
+
+235
+00:20:35,560 --> 00:20:39,380
+هذا الموضوعيعني الـ Cell Cycle Control يعني اللي
+
+236
+00:20:39,380 --> 00:20:43,660
+هي الـ Checkpoints البروتينز عبارة عن Signal
+
+237
+00:20:43,660 --> 00:20:49,180
+وجزيئات داخل الخلية إذا تنشطت بتطلب من الخلية
+
+238
+00:20:49,180 --> 00:20:52,740
+تسوّي الاشي المطلوب اللي هو تنقسم في عندي Growth
+
+239
+00:20:52,740 --> 00:20:56,640
+Factors ودولة راح يكونوا الـ Stimuli from the
+
+240
+00:20:56,640 --> 00:21:00,480
+outside الـ Growth Factors ودولة specific لكل نوع
+
+241
+00:21:00,480 --> 00:21:04,580
+من الخلايا يعني الـ Hemoglobin أو الـ Red Blood
+
+242
+00:21:04,580 --> 00:21:08,190
+Cellsالـ Erythropoietin هو الـ Growth Factor تبعه
+
+243
+00:21:08,190 --> 00:21:13,230
+أو مثلا نقول الـ Azenophils هم الـ Interleukin-5
+
+244
+00:21:13,230 --> 00:21:17,970
+هو اللي بيخليهم يكونوا يتنشطوا مثلا، ففي Growth
+
+245
+00:21:17,970 --> 00:21:20,910
+Factors بس الـ Growth Factor حتى يشتغل و هو برا
+
+246
+00:21:20,910 --> 00:21:26,450
+لازم يكون له Receptor على الـ Cell Surface فدولة
+
+247
+00:21:26,450 --> 00:21:29,790
+في عندي Growth Factors بس خلولي يصير عندي الـ
+
+248
+00:21:29,790 --> 00:21:32,950
+Controlled Proliferation اللي بيعطيني الـ Function
+
+249
+00:21:32,950 --> 00:21:38,780
+المطلوبةوبعدين لما تصير مثلًا بالـ Hematopoiesis
+
+250
+00:21:38,780 --> 00:21:45,020
+للـ White والـ Red والـ Platelets of the blood
+
+251
+00:21:45,020 --> 00:21:49,420
+cells الـ Terminal Differentiation لأنه فيه أنه
+
+252
+00:21:49,420 --> 00:21:54,020
+Transcription Factors وفيه أنه Apoptosis زي أخدته
+
+253
+00:21:54,020 --> 00:21:57,760
+عن الـ Fast Fast Ligand Interaction This is one of
+
+254
+00:21:57,760 --> 00:22:04,950
+the mainStimuli أو Direct Orders for Cells to Die
+
+255
+00:22:04,950 --> 00:22:09,450
+in Programmed Cell Death اللي هو الـ Apoptosis الـ
+
+256
+00:22:09,450 --> 00:22:13,590
+Apoptosis مختلف عن الـ Necrosis الـ Necrosis اللي
+
+257
+00:22:13,590 --> 00:22:20,130
+هو بيكون الخلية بتموت بانفجار وبكون يعني فيه
+
+258
+00:22:20,130 --> 00:22:24,270
+Inflammatory Response الـ Apoptosis الخلية بتتحلل
+
+259
+00:22:24,270 --> 00:22:31,730
+بتتحول إلى كتل صغير من الأكل والـوالـ Proteins
+
+260
+00:22:31,730 --> 00:22:35,490
+والـ Amino Acids والـ Sugars والـ Lipids وبتلتحك
+
+261
+00:22:35,490 --> 00:22:39,270
+بالخلايا اللي حواليها يعني الـ Apoptosis عادة في
+
+262
+00:22:39,270 --> 00:22:42,870
+تحت الميكروسكوب ما بنشوفه ممكن نشوف الخلايا وهي
+
+263
+00:22:42,870 --> 00:22:50,510
+تمقسم بس لما نتموت عادة ما بنشوفهاش كثير فهذه
+
+264
+00:22:53,500 --> 00:22:58,560
+الخطوات الرئيسية والسطحيات لعمل
+
+265
+00:22:58,560 --> 00:23:01,180
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+266
+00:23:01,180 --> 00:23:01,980
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+267
+00:23:01,980 --> 00:23:02,260
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+268
+00:23:02,260 --> 00:23:03,020
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+269
+00:23:03,020 --> 00:23:03,480
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+270
+00:23:03,480 --> 00:23:04,040
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+271
+00:23:04,040 --> 00:23:06,800
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+272
+00:23:06,800 --> 00:23:13,860
+عملية عملية عملية عملية ععن طريق الـDNA Repair
+
+273
+00:23:13,860 --> 00:23:18,560
+Proteins فيه Certain Enzymes وCertain Molecules
+
+274
+00:23:18,560 --> 00:23:26,440
+اللي يعني تحفظ جودة الـReplication من الـDNA لكي
+
+275
+00:23:26,440 --> 00:23:31,280
+لا يحصل أي خطأ في القراءة وبالنسبة لفيه الـProcess
+
+276
+00:23:31,280 --> 00:23:39,460
+of CBG DNA Methylation بـCertain Sites أو
+
+277
+00:23:39,460 --> 00:23:40,920
+Hydroxymethylation
+
+278
+00:23:43,950 --> 00:23:48,830
+وDNA Modification Enzymes هاي بتمثل الـ Epigenetic
+
+279
+00:23:48,830 --> 00:23:53,030
+Control اللي هو بتحكم أي جروب من الجينات هم اللي
+
+280
+00:23:53,030 --> 00:23:55,810
+بيصير اللي لهم الـ Gene Expression مش كل الجينات
+
+281
+00:23:55,810 --> 00:23:59,210
+في كل الخلايا كلهم بيشتغلوا لأ في كل نوع من
+
+282
+00:23:59,210 --> 00:24:04,150
+الخلايا في certain genes that are activated others
+
+283
+00:24:04,150 --> 00:24:08,090
+are suppressed فهذا كله من خلال الـ Epigenetic
+
+284
+00:24:08,090 --> 00:24:13,340
+ControlControl ويله الـ Many Mechanisms زي الـ DNA
+
+285
+00:24:13,340 --> 00:24:16,920
+Methylation، DX Methylation الـ Stone Modification
+
+286
+00:24:16,920 --> 00:24:22,600
+والـ mRNA Control، الـ Micro RNA Control هدولة
+
+287
+00:24:22,600 --> 00:24:27,160
+كلهم Epigenetic Control فكل هما دولة في
+
+288
+00:24:27,160 --> 00:24:33,540
+Interaction بينهم وبين بعض حتى يتم لما نيجي نتطلع
+
+289
+00:24:33,540 --> 00:24:40,660
+على الـ Cancer Cellsفي عدة ملاحظات، هناك خسارة من
+
+290
+00:24:40,660 --> 00:24:45,900
+الـ Genomic Integrity يعني ممكن أنا حكيتها مرة
+
+291
+00:24:45,900 --> 00:24:49,580
+كلمة إنه في certain cancers نلاقي بعض اللي لما
+
+292
+00:24:49,580 --> 00:24:56,480
+تاخد يعني هنا أنت أخدت نفس الخلايا السرطانيةحاولت
+
+293
+00:24:56,480 --> 00:24:59,740
+تدرس شو فارقة بالـ «DNA» والـ «Genetics» أو الـ
+
+294
+00:24:59,740 --> 00:25:04,200
+«Genomics» عن الخلايا الطبيعية ففيه «Loss of
+
+295
+00:25:04,200 --> 00:25:11,600
+Genomic Integrity» «Replication» «Segregation» مش
+
+296
+00:25:11,600 --> 00:25:16,540
+مظبوط، احنا غلطنا فـ «DNA Replication Repair»
+
+297
+00:25:16,540 --> 00:25:20,940
+«Chromosome Stability and Segregation» «Abnormal
+
+298
+00:25:20,940 --> 00:25:24,300
+Epigenetic Control» طبعا يعني هنا الـ «DNA Repair
+
+299
+00:25:24,300 --> 00:25:29,780
+Protein»يعني لما يكون هذا موجود، هي كارثة بتخلي
+
+300
+00:25:29,780 --> 00:25:36,520
+هذا الإنسان معرض جداً يكون عنده سرطان في إيمان
+
+301
+00:25:36,520 --> 00:25:44,520
+بدأت تتكلم، احكي ماشي،
+
+302
+00:25:44,520 --> 00:25:52,540
+فبالنسبة لكل الـ Normal steps if anomalies occur
+
+303
+00:25:52,540 --> 00:25:56,060
+أو if problems occurسيسببون في نهاية الحصول على
+
+304
+00:25:56,060 --> 00:26:01,900
+الـCancer عدد المعاملات أو عدد المصطلحات أو عدد
+
+305
+00:26:01,900 --> 00:26:02,040
+المصطلحات أو عدد المصطلحات أو عدد المصطلحات أو عدد
+
+306
+00:26:02,040 --> 00:26:08,020
+المصطلحات أو عدد المصطلحات أو عدد المصطلحات أو عدد
+
+307
+00:26:08,020 --> 00:26:08,700
+المصطلحات أو عدد المصطلحات أو عدد المصطلحات أو عدد
+
+308
+00:26:08,700 --> 00:26:08,800
+المصطلحات أو عدد المصطلحات أو عدد المصطلحات أو عدد
+
+309
+00:26:08,800 --> 00:26:14,720
+المصطلحات أو عدد المصطلحات أو عدد المصطلحات أو عدد
+
+310
+00:26:14,720 --> 00:26:21,900
+المصطلحات أو عدد المصطلحات أو عدد المصطلحات أو عدد
+
+311
+00:26:21,900 --> 00:26:23,760
+المصطلح
+
+312
+00:26:26,440 --> 00:26:29,140
+متحكمين ممتازين من التحكم الطبيعي
+
+313
+00:26:29,140 --> 00:26:50,720
+‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏
+
+314
+00:26:54,380 --> 00:26:58,620
+اللي بوحدهم كلهم، Radiation وChemicals وViral
+
+315
+00:26:58,620 --> 00:27:03,240
+Infection وDrugs وغيره وغيره وغيره، بالأخير كلهم
+
+316
+00:27:03,240 --> 00:27:07,700
+بيخربوا الـDNA كلهم بيخربوا، بيشتغلوا على الـ…
+
+317
+00:27:07,700 --> 00:27:13,060
+الـ… الـGene Axis تبع الـCell Division من جهة
+
+318
+00:27:13,060 --> 00:27:17,880
+والـCell Proliferation والـApoptosis والنقاط هذه
+
+319
+00:27:17,880 --> 00:27:24,510
+فهي الـGeneral View of the Lectureمنعقد الموضوع
+
+320
+00:27:24,510 --> 00:27:32,810
+أكثر ونحكي بعض الأمثلة أيها الكريم أحكي الله عفوك
+
+321
+00:27:32,810 --> 00:27:37,350
+يا دكتور الله عفوك، فضل بالنسبة لخلايا السرطان
+
+322
+00:27:37,350 --> 00:27:40,370
+اللي نزلت عنها في الـStudy اللي حدثت مش هارد أن
+
+323
+00:27:40,370 --> 00:27:42,990
+تكون الخلال في كل مراحل الـcycle أو في كل مراحل
+
+324
+00:27:42,990 --> 00:27:47,050
+الـkill على طول حياتك عشان تكون في الخلال في مرحلة
+
+325
+00:27:47,050 --> 00:27:52,590
+واحدةنعم، عيد السؤال وعلي صوتك، قريبًا أنا رافع
+
+326
+00:27:52,590 --> 00:27:56,890
+صوت عندي على خير، مش سامعك كثير، كله إن الخلايا
+
+327
+00:27:56,890 --> 00:28:01,230
+السرطانية كمان عندها cell cycle، طبعًا، بس هذا فيه
+
+328
+00:28:01,230 --> 00:28:06,810
+abnormality عادة ال cycle، ولكن عشان يصير مثلًا،
+
+329
+00:28:06,810 --> 00:28:11,270
+يصير lung cancer أو أي سرطان مثلًا في أي خلية،
+
+330
+00:28:11,270 --> 00:28:14,390
+لازم يصير خلل، مش شرط كل ال cycle فيه خلل، بس كيف
+
+331
+00:28:14,390 --> 00:28:19,060
+مرحلة واحدة يصير خلل، بدلة سرطانلأ، لأ، لأ، لأ،
+
+332
+00:28:19,060 --> 00:28:26,780
+اسمع عليه إحنا بالأخير مثلًا مثلًا الـ Tissue زي
+
+333
+00:28:26,780 --> 00:28:34,680
+الـ Lung في مثلًا نفترض مليون سلب مثلًا نفترض هيكي
+
+334
+00:28:34,680 --> 00:28:40,700
+هذولة الأصل إنه مثلًا يعني تقريبًا واحدة بالألف من
+
+335
+00:28:40,700 --> 00:28:46,480
+كل خلية بتنقسم مرة باليوم فإنت المتوقع إنهمنها
+
+336
+00:28:46,480 --> 00:28:52,080
+المليون فيه ألف كل يوم بنقسمه بس حتى تكون الأمور
+
+337
+00:28:52,080 --> 00:28:54,880
+stable وتشوف الـ tissue زي ما هو يعني أنا مثلا
+
+338
+00:28:54,880 --> 00:29:02,720
+الجلد عندي أنا شايفه نفس الحجم، مااختلفش فاللي
+
+339
+00:29:02,720 --> 00:29:09,960
+بيصير أن هالألف اللي انقسموا وصاروا ألفين مقابلهم
+
+340
+00:29:09,960 --> 00:29:16,310
+فيه ألف راح يموتبحيث إنه يظل الرقم مليون ويظل كل
+
+341
+00:29:16,310 --> 00:29:22,130
+يوم ألف يولدوا جديد يعني تكون ألفين اجداد ونخسر
+
+342
+00:29:22,130 --> 00:29:26,590
+ألف بالـ Apoptosis ويظل العدد زي ما هو لما تقول
+
+343
+00:29:26,590 --> 00:29:33,010
+سرطان أنت هذا المليون في مكان صار مليون وربع،
+
+344
+00:29:33,010 --> 00:29:38,090
+مليون ونص، مليونين، تلات ملايين، أربع ملايين فعدد
+
+345
+00:29:38,090 --> 00:29:43,990
+الخلايا عادة بزيدممكن هذا لأن الإنقسام صار أسرع أو
+
+346
+00:29:43,990 --> 00:29:50,150
+إن الخلايا بطلة تموت يعني إنت كان عندك ألف صاروا
+
+347
+00:29:50,150 --> 00:29:54,270
+ألفين لأن ألف خلية انقسمت بس بدل ما يموت ألف مات
+
+348
+00:29:54,270 --> 00:30:00,430
+خمسمية فبتصير أنت بالمحصلة عندك بدل ما هو ألف صار
+
+349
+00:30:00,430 --> 00:30:05,930
+ألف وخمسمية زيادة فلما تشوف أنت tumor معناته يا
+
+350
+00:30:05,930 --> 00:30:13,570
+إما increased cell divisionأو Decreased Apoptosis
+
+351
+00:30:13,570 --> 00:30:19,010
+وبالأخير، حتى يصير ورم، يعني كتلة إضافية مش الكتلة
+
+352
+00:30:19,010 --> 00:30:22,030
+النمو الطبيعي اللي بدك إياها أو اللي موجود أو الـ
+
+353
+00:30:22,030 --> 00:30:27,470
+Control فحتى يكون هذا، عدد الخلايا لازم يزيد يعني
+
+354
+00:30:27,470 --> 00:30:31,450
+هي فيها تلقائي راح تكون، إن شاء الله واضح يا كريم
+
+355
+00:30:31,450 --> 00:30:37,750
+عرفت، دعوني أسألك دعوني أسألك دعوني أسألك دعوني
+
+356
+00:30:37,750 --> 00:30:38,930
+أسألك دعوني أسألك دعوني أسألك
+
+357
+00:30:42,810 --> 00:30:47,530
+أه مالك؟ هل جيتها أنت قولت اللي بقى اللي فيها ال
+
+358
+00:30:47,530 --> 00:30:53,790
+cancer؟ أه الأولى؟ لأ ال fourth، ال رابعة تصبح ال
+
+359
+00:30:53,790 --> 00:30:58,610
+رابعة فيها ال .. في ال رابعة أه هل جيتها عشان فيه
+
+360
+00:30:58,610 --> 00:31:02,970
+رفلية فيها cancer أو فيه فيها normal growth؟ لازم
+
+361
+00:31:02,970 --> 00:31:05,410
+في خلال في مرحلة واحدة من المراحل؟ ولا كل مراحل
+
+362
+00:31:05,410 --> 00:31:12,420
+هذه لازم فيها خلال؟ يا دكتورفي كل نوع من السرطانات
+
+363
+00:31:12,420 --> 00:31:18,000
+فيه بشكل أوضح وأكبر يمكن إنه نوع معين من الـ
+
+364
+00:31:18,000 --> 00:31:21,620
+Anomalies مش كلهم راح تلاقيهم في كل أنواع
+
+365
+00:31:21,620 --> 00:31:26,300
+السرطانات أو لازم كلهم يكونوا وفي الغالب ما بيكون
+
+366
+00:31:26,300 --> 00:31:30,520
+في أي سرطان بس واحدة هي اللي فيها خلال لازم يكون،
+
+367
+00:31:30,520 --> 00:31:36,010
+حكيتلك Multifactorial يعني فيها أكثر من جانببس
+
+368
+00:31:36,010 --> 00:31:39,770
+اللي، اللي، اللي راح نحكي عنه دلوقتي كأمثلة أكتر
+
+369
+00:31:39,770 --> 00:31:46,190
+يعني هاي لكل أنواع السرطانات بشكل عام ماشي، هسة
+
+370
+00:31:46,190 --> 00:31:51,110
+لما نيجي ناخذ سرطان معين كمثال يمكن الآن اللي
+
+371
+00:31:51,110 --> 00:31:56,250
+اكتشفناه مثلا جانب معين بشكل أوضح بس هو في الأخير
+
+372
+00:31:56,250 --> 00:32:02,550
+حتى يسير السرطان لازم يكون في عندي مشكلة في أحد
+
+373
+00:32:02,550 --> 00:32:08,250
+هذه الجوانبفيه تفاوت يمكن في حسب ما هو حسب انت شو
+
+374
+00:32:08,250 --> 00:32:15,290
+درسته ودراسة هذه المواضيع للأسف صعبة جدا يعني انك
+
+375
+00:32:15,290 --> 00:32:22,880
+انت تكون عندك قدرة مثلا واللهأشوف الـ «DNA repair»
+
+376
+00:32:22,880 --> 00:32:26,680
+أو «replication» في السرطان اللي فلاني بدي أخد
+
+377
+00:32:26,680 --> 00:32:30,680
+السخلايا و بدي أعيشهم في المختبر و بدي أخليهم
+
+378
+00:32:30,680 --> 00:32:33,880
+ينقسموا و بدي أدرس الـ«repair» ولا
+
+379
+00:32:33,880 --> 00:32:38,540
+الـ«replication» ولا بدي كذا، يعني هي أمر بيستهل،
+
+380
+00:32:38,540 --> 00:32:46,450
+بس الفكرة أن هذا اللي موجود في كل عموم السرطانةهي
+
+381
+00:32:46,450 --> 00:32:50,850
+ملخص لكل أنواع السرطانات يكون فيه لازم يكون أكتر
+
+382
+00:32:50,850 --> 00:32:56,950
+من مشكلة واحدة يعني في الغالب مش مشكلة وحيدة فقط
+
+383
+00:32:56,950 --> 00:33:00,830
+يعني دايماً السرطانات والـ Autoimmune Diseases
+
+384
+00:33:00,830 --> 00:33:06,530
+بيقولوا عنها إن فيها Multifactorial Pathology يعني
+
+385
+00:33:06,530 --> 00:33:13,330
+تسبب فيها خلل من أكتر من جهة ماشي، هذه ناحية،
+
+386
+00:33:13,330 --> 00:33:18,630
+الناحية الثانيةيعني قيمة الدراسة هذه وفهم هذا
+
+387
+00:33:18,630 --> 00:33:23,470
+المواضيع زي ما راح نحكي في جزء منه في الأخير قضية
+
+388
+00:33:23,470 --> 00:33:30,150
+إنه إذا اكتشفت إنه لنوع سرطان معين a certain
+
+389
+00:33:30,150 --> 00:33:36,790
+pathology is the most important واستطعت to develop
+
+390
+00:33:36,790 --> 00:33:41,050
+a certain type of drug or treatment to counteract
+
+391
+00:33:41,050 --> 00:33:48,060
+it، to change itربما يكون لديك إجابة أو إجابة يعني
+
+392
+00:33:48,060 --> 00:33:51,000
+زي راح ناخد بعدين الـ Transcription Factor
+
+393
+00:33:51,000 --> 00:33:55,640
+Inhibitor الـ Tyrosine Kinase Inhibitor هدولة في
+
+394
+00:33:55,640 --> 00:34:00,840
+بعض أنواع السرطانات ممتازة جدا ويعني فتح وطيور
+
+395
+00:34:00,840 --> 00:34:06,300
+علاج خيالي يعني بتعتبره فالفهم المواضيع هذه
+
+396
+00:34:06,300 --> 00:34:11,340
+المقصود الآن في المرحلة هذه إنه إحنا لازم يكون
+
+397
+00:34:11,340 --> 00:34:16,510
+عندنا استيعاب لشو هيالخطوات المسببة للسرطان
+
+398
+00:34:16,510 --> 00:34:23,830
+وبالتالي هي نوع من الاحتماليات أو تعطينا أفكار على
+
+399
+00:34:23,830 --> 00:34:29,410
+كيفية علاجه، ورح ناخد أمثلة عليه، الآن ما بتكلم عن
+
+400
+00:34:29,410 --> 00:34:34,490
+سرطان محدد، وكل أنواع خلايا الجسم ممكن تتحول
+
+401
+00:34:34,490 --> 00:34:39,350
+للسرطانيعني المكان الوحيد اللي ما عمري سمعت إنه
+
+402
+00:34:39,350 --> 00:34:44,730
+بتتكون فيه سرطان هو الجزء الأول أو الثاني من الـ12
+
+403
+00:34:44,730 --> 00:34:47,970
+يعني
+
+404
+00:34:47,970 --> 00:34:52,870
+هذا النوع، هذا المكان في الجسم من النادر أو عمري
+
+405
+00:34:52,870 --> 00:34:56,270
+ما سمعت إنه فيه سرطان في الـDeudenum في هذا
+
+406
+00:34:56,270 --> 00:34:59,190
+المكان، سرطان في الصمم، في الـOesophagus، في
+
+407
+00:34:59,190 --> 00:35:02,350
+الـSmall Intestine، بالـLarge Intestine، مش عارف
+
+408
+00:35:02,350 --> 00:35:07,330
+إيشبتلاقي كل أنواع الجسم بتلاقي فيه سرطانات جلد،
+
+409
+00:35:07,330 --> 00:35:12,850
+دم، عصاب، عظام أي نوع خلايا بيمكن تتحول للسرطان
+
+410
+00:35:12,850 --> 00:35:21,910
+وهي كله بيكون في الـ… شو اسمه؟ بيكون من الـ…
+
+411
+00:35:21,910 --> 00:35:27,250
+الـAbnormality البطارية كانت تتضعف فهي كلها بيشير
+
+412
+00:35:27,250 --> 00:35:31,800
+Abnormality بالنسبة للـCell Cycle Regulationبالـ
+
+413
+00:35:31,800 --> 00:35:35,180
+«DNA»، يعني بالأخير في مشكلة في الـ «DNA» أتأمل
+
+414
+00:35:35,180 --> 00:35:40,420
+النقطة واضحة يا كريم أهلا و شكرا يا دكتور أهلا
+
+415
+00:35:40,420 --> 00:35:48,240
+وسهلا فالآن العلماء
+
+416
+00:35:48,240 --> 00:35:56,080
+أو التدارسين للمواضيع هذه لكل نوع من السلطنات
+
+417
+00:35:56,080 --> 00:36:03,090
+أحيانًا بينجحواإنه يتعرفوا أو يعرفوا الـ «site»
+
+418
+00:36:03,090 --> 00:36:07,970
+حسب ما راح نتفرج بعدين كيف درسوها وكيف اكتشفوها
+
+419
+00:36:07,970 --> 00:36:12,550
+إنه السرطان اللي فلاني في المكان اللي فلاني فيه
+
+420
+00:36:12,550 --> 00:36:17,670
+جين محدد هو اللي بيكون فيه certain mutations،
+
+421
+00:36:17,670 --> 00:36:22,270
+anomalies، changes فيحيث إنه بيعطينا بالأخير
+
+422
+00:36:22,270 --> 00:36:33,230
+السرطان هذا فالـ «جين» المسؤول عن تكوين أحيانًا
+
+423
+00:36:33,230 --> 00:36:38,470
+الـ «بروتين» related to that type of cancer أو
+
+424
+00:36:38,470 --> 00:36:42,450
+للكترول في نوع معين من الـ «كانسر» بيسموه «proto
+
+425
+00:36:42,450 --> 00:36:46,630
+-oncogene» «onco» for cancer «oncology» يعني علم
+
+426
+00:36:46,630 --> 00:36:50,630
+السرطان هذا المحفز
+
+427
+00:36:50,630 --> 00:36:56,600
+لنمو السرطان المعين هذالكل نوع ورح نشوف أمثل عليهم
+
+428
+00:36:56,600 --> 00:37:05,100
+بدنا نسميه هيك بشكل عام «Proto-Oncogene» فإذا كان
+
+429
+00:37:05,100 --> 00:37:10,700
+هذا الجين المطلوب منه ينتج بروتين معين الأصل كان
+
+430
+00:37:10,700 --> 00:37:16,820
+كمية قليلة أو كمية معينة وكذا الـ… الـ…
+
+431
+00:37:16,820 --> 00:37:20,540
+الـAnomalies that you can expect and try to find
+
+432
+00:37:20,540 --> 00:37:23,860
+what type of problem there isبإمكانها أن يكون هناك
+
+433
+00:37:23,860 --> 00:37:29,340
+ميوتيشنات كودية يعني بيعطيك البروتين الهوانة الـ
+
+434
+00:37:29,340 --> 00:37:35,200
+Regulatory mutations الـ الـ ميوتيشن اللي حاطينها
+
+435
+00:37:35,200 --> 00:37:41,680
+يعني تطلع في المنطقة اللي هي جزء من التركيب
+
+436
+00:37:41,680 --> 00:37:47,760
+لبروتين نفسه اللي موجود أكتر في الـ Cancer ماشي
+
+437
+00:37:47,760 --> 00:37:52,980
+فهذه بعض الـ mutations بتكون بهذا الشكل أحياناًحتى
+
+438
+00:37:52,980 --> 00:37:59,360
+يصير الـ Extraction لأي جين في الـ Regulatory يعني
+
+439
+00:37:59,360 --> 00:38:05,880
+الـ Promoter Area، الـ Initiator Area المنطقة اللي
+
+440
+00:38:05,880 --> 00:38:10,360
+قبل اللي راح تخلي البروتين هذا ينقرة فهذه
+
+441
+00:38:10,360 --> 00:38:14,880
+Regulatory Mutations في مرات معينة، هناك مشكلة قبل
+
+442
+00:38:14,880 --> 00:38:19,440
+ذلكيعني البروتين الأخير بالأخير راح يطلع نفس
+
+443
+00:38:19,440 --> 00:38:23,120
+البروتين اللي بيكون بالخلية العادية بس هنا كميته
+
+444
+00:38:23,120 --> 00:38:29,420
+أكبر وهذا الاختلاف أحيانًا الـ Translocation مثلًا
+
+445
+00:38:29,420 --> 00:38:33,860
+من قطعة ثانية راح ناخد مثال عليها الـ Philadelphia
+
+446
+00:38:33,860 --> 00:38:38,700
+chromosome نسميه بيكون اللي بيطلع عندي بروتين
+
+447
+00:38:38,700 --> 00:38:43,340
+مختلف تمامًا وظيفته أحيانًا مختلفةوأحيانًا في عندي
+
+448
+00:38:43,340 --> 00:38:47,980
+gene amplification هنا نفس الـ gene ككمية بس
+
+449
+00:38:47,980 --> 00:38:52,380
+الوظيفة صارت أقوى بكتير وأحيانًا بيكون أنه بيصير
+
+450
+00:38:52,380 --> 00:38:57,420
+عندي amplification بدل ما يكون عندي one copy of
+
+451
+00:38:57,420 --> 00:39:01,600
+that gene بيصير عندي multiple copies ويكون بالتالي
+
+452
+00:39:01,600 --> 00:39:05,420
+إذا كلهم صارلهم transcription فهيصير برضه عندي
+
+453
+00:39:05,420 --> 00:39:08,560
+excessive amount of the protein which is normal أو
+
+454
+00:39:08,560 --> 00:39:13,790
+similar to the original proteinهذه كلها ميكانيزمات
+
+455
+00:39:13,790 --> 00:39:17,130
+ميوتيشيالية تؤدي إلى اكتفاء البروتو-أنكوجين
+
+456
+00:39:17,130 --> 00:39:21,550
+أحياناً تحصل عندها اكتفاء كبير في أماكن معينة
+
+457
+00:39:21,550 --> 00:39:27,890
+وتكون نتيجة أنواع الاختلالات هذه سواء في الـCoding
+
+458
+00:39:27,890 --> 00:39:32,250
+Mutation أو الـRegulatory Mutation أو التغيير أو
+
+459
+00:39:32,250 --> 00:39:36,230
+التعيين من مجموعة أخرى مع مفعولة بروتين جديد أو
+
+460
+00:39:36,230 --> 00:39:40,780
+بروتين جديد تعمل أكتر أو أقلأو على الـGene
+
+461
+00:39:40,780 --> 00:39:47,740
+Amplification فهذه ميكانيزات مختلفة أحنا عادةً
+
+462
+00:39:47,740 --> 00:39:52,360
+الـNormal Cell نتوقعها
+
+463
+00:39:52,360 --> 00:39:58,260
+تظلها بشكل معيّر الـStages بيحصل أولاً بـIncreased
+
+464
+00:39:58,260 --> 00:40:02,760
+Proliferation وبتكون إنه صارت أندي خلل في مكان A
+
+465
+00:40:04,210 --> 00:40:08,950
+وبعدين صار عندى mutation in site B وبعدين عندي
+
+466
+00:40:08,950 --> 00:40:13,410
+mutation في الـthird place يعني اللي بدى واحد
+
+467
+00:40:13,410 --> 00:40:20,390
+يتذكره إنه إحنا في الغالب ما بنتكلم عن إنه single
+
+468
+00:40:20,390 --> 00:40:24,230
+thing that will lead to the cancer it has to be at
+
+469
+00:40:24,230 --> 00:40:28,670
+multiple sites وبالتالي بعد ال increase
+
+470
+00:40:28,670 --> 00:40:33,140
+proliferation مثلا في الـGIبيعطينا مثلًا الـ
+
+471
+00:40:33,140 --> 00:40:37,200
+Benign Adenoma الـ Adenoma بتكون إنه إزالة الـ
+
+472
+00:40:37,200 --> 00:40:39,900
+proliferation وبتكون it's a benign looking thing
+
+473
+00:40:39,900 --> 00:40:44,880
+هذه بتصير Early Neoplasia، Progressive Neoplasia،
+
+474
+00:40:44,880 --> 00:40:48,600
+مع ال progression أكتر، بيصير عندي بالأخير الـ
+
+475
+00:40:48,600 --> 00:40:53,360
+Carcinoma، والأسوأ نوع اللي هو بيروح بالوطن، يعني
+
+476
+00:40:53,360 --> 00:40:56,940
+بتطور أكتر لإنه يصير Endometastasis، and this is
+
+477
+00:40:56,940 --> 00:41:04,400
+way different than the normal cell.غير الـ
+
+478
+00:41:04,400 --> 00:41:09,380
+Mutations في Multiple Genes الـ Chromosomal
+
+479
+00:41:09,380 --> 00:41:17,000
+Unemployment يعني أنا إذا الـ Normal Tissue بشوف
+
+480
+00:41:17,000 --> 00:41:24,060
+الخلايا 2N doing their work و Stable و بتكون
+
+481
+00:41:24,060 --> 00:41:30,630
+حالياً بتكونفنشينال وكويسة الـ cancer cells
+
+482
+00:41:30,630 --> 00:41:34,670
+وبالذات لما نكون كل ما هو more advanced more
+
+483
+00:41:34,670 --> 00:41:42,810
+metastatic more aggressive ماشي بنلاقي increased
+
+484
+00:41:42,810 --> 00:41:46,910
+genetic anomalies including chromosomal aneuplosis
+
+485
+00:41:46,910 --> 00:41:53,590
+يعني الـ DNA repair و modification و الـ chromatin
+
+486
+00:41:53,590 --> 00:41:57,620
+modification الـ genes هذا بالأولبس كل ما هذه
+
+487
+00:41:57,620 --> 00:42:02,320
+الخلايا بتتكثروا بسرعة كتير السرعة بتخلي احتمالية
+
+488
+00:42:02,320 --> 00:42:06,620
+الأخطاء تصير أكبر وهنا بتصير الأخطاء أكتر على
+
+489
+00:42:06,620 --> 00:42:11,360
+مستوى الـChromosomes كلها مش بس Single Gene أو الـ
+
+490
+00:42:11,360 --> 00:42:16,950
+Proto Oncogene الأول بس فبالتالي لما واحد يشوفالـ
+
+491
+00:42:16,950 --> 00:42:20,590
+Advanced Cancer مثلًا اللي موجود في الـ Metastasis
+
+492
+00:42:20,590 --> 00:42:26,550
+بسهولة بيلاقي 3N، 4N، 8N of Genetic Material
+
+493
+00:42:26,550 --> 00:42:31,870
+Highly Abnormal ويكون هذا جزء من الـ
+
+494
+00:42:31,870 --> 00:42:38,230
+Aggressiveness يعني ليش السرطان هذا سيء وشرس
+
+495
+00:42:38,230 --> 00:42:42,230
+وبيهاجم بسرعة وبينتشر بسرعة؟ فبيكون لأن الـ
+
+496
+00:42:42,230 --> 00:42:44,770
+Control على الجينات سبعته سيء
+
+497
+00:42:47,210 --> 00:42:57,950
+فا I think this يعني slide أو يعني الفكرة تبعته
+
+498
+00:42:57,950 --> 00:43:05,730
+إنه regardless of whatever cancer wherever the
+
+499
+00:43:05,730 --> 00:43:10,170
+cancer occurs sporadically أو individual أو نتيجة
+
+500
+00:43:10,170 --> 00:43:12,770
+من ميوسماتيكية أو مستلزمة أو مستلزمة أو مستلزمة أو
+
+501
+00:43:12,770 --> 00:43:13,030
+مستلزمة أو مستلزمة أو مستلزمة أو مستلزمة أو
+
+502
+00:43:13,030 --> 00:43:14,650
+مستلزمة أو مستلزمة أو مستلزمة أو مستلزمة أو
+
+503
+00:43:14,650 --> 00:43:15,030
+مستلزمة أو مستلزمة أو مستلزمة أو مستلزمة أو
+
+504
+00:43:15,030 --> 00:43:16,660
+مستلزمة أو مستلزمة أو مستيعني حكينا أو يمكن راح
+
+505
+00:43:16,660 --> 00:43:22,580
+نحكي بعد شوية إنه السرطان أحيانًا فيه أشياء منه
+
+506
+00:43:22,580 --> 00:43:27,920
+genetic و inherited يعني راح ناخد أمثلة عليها وبعض
+
+507
+00:43:27,920 --> 00:43:32,880
+الأشياء الموجودة ومعروفة ممكن واحد يدرسها في
+
+508
+00:43:32,880 --> 00:43:39,920
+certain families فسواء هو individual أو سواء هو في
+
+509
+00:43:39,920 --> 00:43:48,660
+family أوكـ Hereditary trait بالأخير السرطان هو
+
+510
+00:43:48,660 --> 00:43:54,700
+Genetic Phenomenon Genetic Disease لأنه سواء الـ
+
+511
+00:43:54,700 --> 00:43:59,480
+Oncogene بالاندويدوال أو إذا بالـ Family ويكون
+
+512
+00:43:59,480 --> 00:44:03,840
+أحياناً فيه tumor suppressor gene على عكس الـ
+
+513
+00:44:03,840 --> 00:44:11,280
+Oncogenes يعني الـ Genes involved in cancerتكون من
+
+514
+00:44:11,280 --> 00:44:15,420
+نوعين مختلفة في الـ Oncogenes اللي بيزودوا السرطان
+
+515
+00:44:15,420 --> 00:44:19,200
+وفي الـ Tumor Suppressor Genes وكثير من الـ Genes
+
+516
+00:44:19,200 --> 00:44:25,260
+ومهمتهم هو تقليل الـ Cancer فإذا هذا النوع من الـ
+
+517
+00:44:25,260 --> 00:44:30,000
+Genes صار له Suppression صار له Inhibition
+
+518
+00:44:30,000 --> 00:44:34,680
+وSuppression لـ Tumor Suppressor Genes فنفي النفي
+
+519
+00:44:34,680 --> 00:44:41,700
+اتباع، وبالتالي بيصير عندي السرطانفهي يعني أنا بظن
+
+520
+00:44:41,700 --> 00:44:50,140
+اقرأوا الجزء هذا ويعني هاي مفاهيم مهمة تداخل بين
+
+521
+00:44:50,140 --> 00:44:57,800
+الـ الـ genes وبالنسبة للـ يعني different types of
+
+522
+00:44:57,800 --> 00:45:03,720
+problems with different types of cancer
+
+523
+00:45:06,060 --> 00:45:10,820
+من الأشياء اللي حكينا عنهم أحيانًا في certain،
+
+524
+00:45:10,820 --> 00:45:15,300
+many types of genes and for different types of
+
+525
+00:45:15,300 --> 00:45:22,520
+cells أنه for any type of cell to either divide أو
+
+526
+00:45:22,520 --> 00:45:28,340
+أحيانًا أبكتوث أو do anything it starts with a
+
+527
+00:45:28,340 --> 00:45:31,740
+certain stimulus اللي هو الـHormone اللي بدنا
+
+528
+00:45:31,740 --> 00:45:38,140
+نسميه الـLigam هناالـ L for Ligand فالـ Ligand حتى
+
+529
+00:45:38,140 --> 00:45:44,220
+يشتغل بذات الـ protein hormones إذا كربوهيرد، إذا
+
+530
+00:45:44,220 --> 00:45:46,460
+lipid كربوهيرد، كربوهيرد، كربوهيرد، كربوهيرد،
+
+531
+00:45:46,460 --> 00:45:47,300
+كربوهيرد، كربوهيرد، كربوهيرد، كربوهيرد، كربوهيرد،
+
+532
+00:45:47,300 --> 00:45:48,060
+كربوهيرد، كربوهيرد، كربوهيرد، كربوهيرد، كربوهيرد،
+
+533
+00:45:48,060 --> 00:45:50,900
+كربوهيرد، كربوهيرد، كربوهيرد، كربوهيرد، كربوهيرد،
+
+534
+00:45:50,900 --> 00:45:54,080
+كربوهيرد، كربوهيرد، كربوهيرد، كربوهيرد، كربوهيرد،
+
+535
+00:45:54,080 --> 00:45:58,840
+كربوهيرد، كربوهيرد،
+
+536
+00:45:58,840 --> 00:46:08,950
+كربالـ Cell Surface Receptor مرات كتير بيكون يعني
+
+537
+00:46:08,950 --> 00:46:15,230
+شوي متبعد عن بعضه لما يصير Interaction بين الـ
+
+538
+00:46:15,230 --> 00:46:21,910
+Cell Surface Receptor مع الـ Ligand تبعه بيصير
+
+539
+00:46:21,910 --> 00:46:27,730
+بيقولوله «confirmational change» يعني شكل البروتين
+
+540
+00:46:27,730 --> 00:46:33,200
+بتغيربنضب على بعض وبتغير فهنا المثال اللي حاطينه
+
+541
+00:46:33,200 --> 00:46:37,440
+إنه بعد ما كانت الـ two chains بعاد عن بعض صار
+
+542
+00:46:37,440 --> 00:46:44,580
+نقراب و became activated مرات كتيرة بكون الـ
+
+543
+00:46:44,580 --> 00:46:48,640
+enzyme which is a kinase اللي هو يعني وظيفة وظيفة
+
+544
+00:46:48,640 --> 00:46:58,810
+phosphate على الـ group بكون incorporatedإلى الـ
+
+545
+00:46:58,810 --> 00:47:05,550
+Cell Surface Receptor يعني يكون جزء منه فلما نكون
+
+546
+00:47:05,550 --> 00:47:08,770
+بعيد، بيكون هذا مش شرذان لما هدول القطعة تانية
+
+547
+00:47:08,770 --> 00:47:15,110
+بعادة عن بعض بعد ما يشوف الـ Cell Surface Receptor
+
+548
+00:47:15,110 --> 00:47:19,370
+يشوف الـLigand أو الهرمون أو الـ Stimulus بيصير
+
+549
+00:47:19,370 --> 00:47:24,210
+اندياaktivation للفعلين بضيف الـ unit of phosphate
+
+550
+00:47:24,210 --> 00:47:34,910
+on itهذه نسميها steps of signal transduction وهنا
+
+551
+00:47:34,910 --> 00:47:38,610
+حاطيني على مثال الـ Retinoplastoma أو الـ
+
+552
+00:47:38,610 --> 00:47:39,550
+Retinoplastoma أو الـ Retinoplastoma أو الـ
+
+553
+00:47:39,550 --> 00:47:39,990
+Retinoplastoma أو الـ Retinoplastoma أو الـ
+
+554
+00:47:39,990 --> 00:47:41,070
+Retinoplastoma أو الـ Retinoplastoma أو الـ
+
+555
+00:47:41,070 --> 00:47:42,990
+Retinoplastoma أو الـ Retinoplastoma أو الـ
+
+556
+00:47:42,990 --> 00:47:44,410
+Retinoplastoma أو الـ Retinoplastoma أو الـ
+
+557
+00:47:44,410 --> 00:47:44,550
+Retinoplastoma أو الـ Retinoplastoma أو الـ
+
+558
+00:47:44,550 --> 00:47:47,310
+Retinoplastoma أو الـ Retinoplastoma أو الـ
+
+559
+00:47:47,310 --> 00:47:49,870
+Retinoplastoma أو الـ Retinoplastoma أو الـ
+
+560
+00:47:49,870 --> 00:47:56,010
+Retinoplastoma أو الـ Retinoplastoma
+
+561
+00:47:56,010 --> 00:47:59,420
+أو الـ Retinالتغيير في تغيير الوصول للإشعار الهاتف
+
+562
+00:47:59,420 --> 00:48:04,520
+بيصير عندي ركوots of multiple proteins and
+
+563
+00:48:04,520 --> 00:48:08,600
+activate other kinases and small g-proteins that
+
+564
+00:48:08,600 --> 00:48:12,500
+in turn activate various transcription factors
+
+565
+00:48:12,500 --> 00:48:20,360
+يعني بالأخير أنا لما مثلا ييجي هرمون على الـ cell
+
+566
+00:48:20,360 --> 00:48:24,740
+surface وتشوف الخلية يتفاعل مع الـ receptor تبعه
+
+567
+00:48:25,650 --> 00:48:29,110
+بالأخير إذا بقى بيصير عندي Cell Division أو New
+
+568
+00:48:29,110 --> 00:48:33,470
+Protein Function لازم الـ Stimulus تصل الـ Nucleus
+
+569
+00:48:33,470 --> 00:48:41,630
+فتبدأ في الغالب بـ Kinases زي الـ Jax الـ Jax Just
+
+570
+00:48:41,630 --> 00:48:45,830
+Another Kinase زي ما يقول وضيفته إنه يعمل
+
+571
+00:48:45,830 --> 00:48:50,770
+Phosphorylation فالـ Phosphorylation هنا بعدين
+
+572
+00:48:50,770 --> 00:48:55,730
+بيكون خطوة أو أكتر هنابالأخير بيصير عندي
+
+573
+00:48:55,730 --> 00:48:59,790
+Transcription Factor Transcription اللي هو Change
+
+574
+00:48:59,790 --> 00:49:07,950
+of DNA to RNA يعني بيفتح الـ DNA في محل معين بيصير
+
+575
+00:49:07,950 --> 00:49:14,750
+له Transcription لـ Messenger RNA فالـ Changes هذه
+
+576
+00:49:15,600 --> 00:49:19,580
+بالأخير حتى يصير عندي cancer الـ end result should
+
+577
+00:49:19,580 --> 00:49:23,000
+be to stimulate proliferation to suppress
+
+578
+00:49:23,000 --> 00:49:27,620
+apoptosis واحدة منها، يعني ياها يا هي، بطريقتين
+
+579
+00:49:27,620 --> 00:49:33,800
+هدولة، فبالأخير احنا بكل السلطنات لازم نحاول نفهم
+
+580
+00:49:33,800 --> 00:49:41,370
+ال steps هذهوأحيانًا هذه تعطينا بالأول رؤية ونظرة
+
+581
+00:49:41,370 --> 00:49:46,470
+وفهم لليش السرطان اتكوّن بس ممكن تعطينا حلول في
+
+582
+00:49:46,470 --> 00:49:50,050
+بعض أنواع السرطانات زي ما راح نشوف كمان بعد شوية
+
+583
+00:49:50,050 --> 00:49:54,110
+في أسئلة؟
+
+584
+00:49:54,110 --> 00:50:04,610
+الآن في أمثلة على الـTumour Suppressor Genes يعني
+
+585
+00:50:04,610 --> 00:50:10,690
+الصراحةالأمثلة هذولة والجينات اللي راح نحكي عنهم
+
+586
+00:50:10,690 --> 00:50:18,250
+ونلاحظ عليهم أنه صرنا نعرف عنهم من دراسة خلايا
+
+587
+00:50:18,250 --> 00:50:27,390
+السرطانات وتبعات المرضى يعني هنا حاطين في حالات
+
+588
+00:50:27,390 --> 00:50:32,390
+الـSporadic Cases الـRetinoplastoma مثلا لهذا
+
+589
+00:50:32,390 --> 00:50:40,740
+الأشيأنا بدي يعني اتطلع على كل الجدول هذا ماشي بدي
+
+590
+00:50:40,740 --> 00:50:47,040
+بس تحفظوا Bracket 1 و Bracket 2 ماشي الـ Bracket 1
+
+591
+00:50:47,040 --> 00:50:55,080
+يعني حتى زي ما بقول الواحد يتذكرها يعني بدنا نطلع
+
+592
+00:50:55,080 --> 00:50:58,380
+شوية يعني هي في الطب يعني بس بدنا ندخل على التمثيل
+
+593
+00:50:58,380 --> 00:51:03,340
+شويةمن الممثلات المشهورات «واجونة على الأردن»
+
+594
+00:51:03,340 --> 00:51:07,280
+«زاروا مخيمات اللاجئين» «ولها نشاط إنساني»
+
+595
+00:51:07,280 --> 00:51:15,140
+«أنجلينا جولي» تسمعوا فيها صح؟ ممثلة مشهورة اللي
+
+596
+00:51:15,140 --> 00:51:22,700
+حدا بيشوف أفلام بيلاقيها يعني معروفة هاي الممثلة
+
+597
+00:51:22,700 --> 00:51:26,380
+عندها «very strong family history of bilateral
+
+598
+00:51:26,380 --> 00:51:28,320
+breast cancer»
+
+599
+00:51:30,430 --> 00:51:35,730
+والـ Braca 1 طلع Positive عندها و Two Doses فعملت
+
+600
+00:51:35,730 --> 00:51:40,230
+Breast يعني Mastectomy Bilateral وهي ما عندهاش
+
+601
+00:51:40,230 --> 00:51:46,470
+سرطانات فالـ ال .. ال .. بالذات الـ Braca 1 و
+
+602
+00:51:46,470 --> 00:51:52,370
+Braca 2 إذا بدك تنسى بقية الأشياء ماشي انساهن بس
+
+603
+00:51:52,370 --> 00:51:57,590
+هدولة احفظهن كمثال على هذا الأمر ماشي
+
+604
+00:51:59,870 --> 00:52:08,270
+فالـ يعني راح نشوف بعدين كيف تم عملية اكتشاف إن
+
+605
+00:52:08,270 --> 00:52:12,050
+هذا الـ gene هو المسؤول أو إشي قريب من هذا المكان
+
+606
+00:52:12,050 --> 00:52:14,430
+هو المسؤول عن السرطان هذا
+
+607
+00:52:18,220 --> 00:52:24,080
+فالأنواع يعني Retinoblastoma I ولقوا بعدين الـ
+
+608
+00:52:24,080 --> 00:52:27,960
+Protein تبعه ثواني يا كريم أخلص الجملة وبعدين
+
+609
+00:52:27,960 --> 00:52:34,920
+بخليك تسأل الـ TP53 يعني لاحظوا الشغل الـ Gene
+
+610
+00:52:34,920 --> 00:52:41,740
+دائماً كبتة Letter الـ Gene Product والبروتين
+
+611
+00:52:41,740 --> 00:52:46,860
+بيحطوه Small Letter أحياناًإحنا على الـMolecular
+
+612
+00:52:46,860 --> 00:52:53,220
+Weight يعني مثلًا مرات بيسموه Protein بيه 110 وزنه
+
+613
+00:52:53,220 --> 00:53:01,100
+110 بيه Protein بيه GP 160، GP 120، GP 41 تبعين
+
+614
+00:53:01,100 --> 00:53:07,460
+الـHIV وغيره وغيره فهي لها معاني بالنسبة لكيف على
+
+615
+00:53:07,460 --> 00:53:11,340
+شو بندور فالـ…
+
+616
+00:53:11,340 --> 00:53:16,220
+فيه a lot of cancersWe said they can be familial
+
+617
+00:53:16,220 --> 00:53:19,980
+ويكون يعني strong association with certain types
+
+618
+00:53:19,980 --> 00:53:26,060
+of genes و الـ BRCA1 و BRCA2 بالـ breast cancer و
+
+619
+00:53:26,060 --> 00:53:30,300
+الـ ovarian cancer والأنواع الثانية في الأنواع
+
+620
+00:53:30,300 --> 00:53:35,880
+الثانية أنا مش عارفهم كتير يعني بده الواحد لما
+
+621
+00:53:35,880 --> 00:53:42,750
+ييجي يتعامل مع حاله يحاول عشان يفهم ليش الـالمرض
+
+622
+00:53:42,750 --> 00:53:46,430
+الإفلاني، الدواء الإفلاني بيفيدني، اتفضل يا كريم
+
+623
+00:53:46,430 --> 00:53:50,030
+كريم
+
+624
+00:53:50,030 --> 00:53:53,650
+كيف تواجد الجين هذا الأول في جسم الإنسان حد ما
+
+625
+00:53:53,650 --> 00:53:59,290
+ممكن يؤدي لتحرى ويهدى السلطان؟ إيش هو؟ مرة ثانية
+
+626
+00:53:59,290 --> 00:54:04,670
+تواجد الجين الأول، لو يتواجد هي في جسم الإنسان،
+
+627
+00:54:04,670 --> 00:54:08,710
+هذا بلقى …ما فهمتش قانون الجين الأول، مافهمتش،
+
+628
+00:54:08,710 --> 00:54:09,490
+فهمني السؤال
+
+629
+00:54:13,030 --> 00:54:16,790
+في العمول الأول، اللي فيه الجينات، لو أي جين يهدف
+
+630
+00:54:16,790 --> 00:54:19,630
+إلى جسد الجسم، هذا بقدر لنسبة كبيرة، يعني إن الناس
+
+631
+00:54:19,630 --> 00:54:22,410
+بيتسرطر… –لو أي جين من الجسم، من هدول الجينات،
+
+632
+00:54:22,410 --> 00:54:27,650
+ماله؟ –مثلا، عليك تقولي مدرسة، ده سهل، لو هدفت
+
+633
+00:54:27,650 --> 00:54:29,670
+واحدة لجسم الإنسان، يعني لنسبة كبيرة إنه هيكي
+
+634
+00:54:29,670 --> 00:54:34,210
+يتسرط أو يتسرط كذا؟ –لأ، لأ، هم هدول الجينات، كل
+
+635
+00:54:34,210 --> 00:54:39,090
+غالب، لأ، وهن الأصل إنهم موجودات، بس certain قليل،
+
+636
+00:54:39,090 --> 00:54:45,320
+certain mutationبشكل معين هي اللي بتعطينا إنه
+
+637
+00:54:45,320 --> 00:54:51,320
+الارتباط مع السرطان يعني الـ RB1 هذا بالـ
+
+638
+00:54:51,320 --> 00:54:54,800
+Retinoblastoma اللي هي نوع من السرطان، وهنا بتكون
+
+639
+00:54:54,800 --> 00:55:00,500
+familial بالأخر هو Cell Cycle Regulator، ماشي؟
+
+640
+00:55:00,500 --> 00:55:04,820
+وإله دخل في أكتر من شغل يعني بالـ Retinoblastoma،
+
+641
+00:55:04,820 --> 00:55:08,400
+بالـSmall Cell Cancer، بالـBreast Cancer لأخو مثل
+
+642
+00:55:08,400 --> 00:55:14,790
+هذا البروتين، إله دخلفاهم عليك كيف؟ هدولة الجينات
+
+643
+00:55:14,790 --> 00:55:20,850
+الأصل إن هما موجودين وطبيعية بس هنا إحنا بنحطهم
+
+644
+00:55:20,850 --> 00:55:28,850
+كمثال على جين هو بالأصل وظيفته إنه يكون suppressor
+
+645
+00:55:28,850 --> 00:55:33,570
+gene tumor suppressor gene بحيث إنه هاي الـnormal
+
+646
+00:55:33,570 --> 00:55:40,050
+function تبعه فلما يكون فيصير disorderماشي أو
+
+647
+00:55:40,050 --> 00:55:46,410
+mutation أو anomaly بشكل معين بنتج عنه سرطان معين
+
+648
+00:55:46,410 --> 00:55:52,310
+زي هذه الأنواع لكل نوع عشان الممثل هذه احفظ الـ
+
+649
+00:55:52,310 --> 00:55:59,030
+Brachia 1 و Brachia 2 ماشي يعني الصراحة يا كريم
+
+650
+00:55:59,030 --> 00:56:07,090
+أسماء الجينات وشو المرض اللي بتسوي ما أظن حد بيقدر
+
+651
+00:56:07,090 --> 00:56:11,990
+يحفظهبس RB يعني Retinoblastoma يمكن واضحة شوية
+
+652
+00:56:11,990 --> 00:56:17,250
+المقال البقية، ليش علاقتها بهذا السرطان، شو دخلها
+
+653
+00:56:17,250 --> 00:56:21,670
+و ليش هيك و ليش هيك، مابعرف وما أظن يعني إذا أنت
+
+654
+00:56:21,670 --> 00:56:26,570
+ماكنت متخصص إنك بدك تدرس هذا الجانب إنه إيه له
+
+655
+00:56:26,570 --> 00:56:34,460
+قيمة عندك يعني، ماشي؟فاحنا بس خلّينا يعني نفهم الـ
+
+656
+00:56:34,460 --> 00:56:41,580
+Concept إنه يعني الـ Mutation في هذا الـ Site can
+
+657
+00:56:41,580 --> 00:56:48,600
+be tested وبالتالي أحيانًا نستفيد منها إنه مثلًا
+
+658
+00:56:48,600 --> 00:56:54,660
+والله يعني راح نشوف بعدين إنه اللي بيكون عنده هذا
+
+659
+00:56:54,660 --> 00:56:59,150
+النوع ممكن فيه دوة معينة بيفيدهشايف علي؟ ممكن إذا
+
+660
+00:56:59,150 --> 00:57:02,530
+شُكت كتير من هذه الأشكال أنا بدي أفرّق هل هي
+
+661
+00:57:02,530 --> 00:57:06,350
+cancerous ولا pre-cancerous اللي هي يعني لسه
+
+662
+00:57:06,350 --> 00:57:13,430
+benign فوجود الـ الـ الـ mutations بشكل معين في
+
+663
+00:57:13,430 --> 00:57:18,130
+أشياء معينة يخليني أشك أكتر إنه سرطان أو
+
+664
+00:57:18,130 --> 00:57:21,590
+aggressive أو يفيدوا إشي أو كده يعني أنا ضربتلك
+
+665
+00:57:21,590 --> 00:57:27,220
+مثال على الـ BRCA1 و BRCA2للممثلة عملت major
+
+666
+00:57:27,220 --> 00:57:32,760
+procedure bilateral mastectomy حطت implants ويعني
+
+667
+00:57:32,760 --> 00:57:38,280
+غيرت الشكل أو الجسم خوفاً من السرطان لأنه فيه
+
+668
+00:57:38,280 --> 00:57:44,780
+familial incidents بشكل قوي كتير، واضح؟
+
+669
+00:57:44,780 --> 00:57:47,980
+نعم، كنت أقول إن بقيت أملك الـ mastectomy جاب ما
+
+670
+00:57:47,980 --> 00:57:53,270
+يكون سرطانكنت بتبقى أعرف أن الـ «أندوطفرا» هذا كنت
+
+671
+00:57:53,270 --> 00:57:57,410
+تفيرة أو إستمال كبير من الـGangster Cancer أه لأ،
+
+672
+00:57:57,410 --> 00:58:02,190
+بالذات الأنواع الـFamilial هي الطفرة موجودة
+
+673
+00:58:02,190 --> 00:58:07,570
+بالعائلة كلها، ماشي، في تفاوت أحيانًا very
+
+674
+00:58:07,570 --> 00:58:10,610
+aggressive أحيانًا very late، حسب إذا في أشياء
+
+675
+00:58:10,610 --> 00:58:16,110
+تانية، بس النقطة كمان اتذكر أنهمش بس واحدة كافية
+
+676
+00:58:16,110 --> 00:58:19,750
+حتى يتكون سرطان لازم يكون أكتر من محله وأكتر من
+
+677
+00:58:19,750 --> 00:58:24,550
+مكانه بس وجود إشي معين أحياناً إذا فيه سهولة أننا
+
+678
+00:58:24,550 --> 00:58:29,950
+ندرسها راح يكون very suggestive وممكن على ضوءها
+
+679
+00:58:29,950 --> 00:58:34,470
+الواحد يقرر يعمل إشي preventive يعني زي ما حكينا
+
+680
+00:58:34,470 --> 00:58:37,770
+عن هذه الممثلة، وشو عندنا؟ ناشي؟
+
+681
+00:58:40,910 --> 00:58:51,650
+الـ الـ فيه concept يعني أنا أظن كمان مهم بالنسبة
+
+682
+00:58:51,650 --> 00:58:56,790
+الـ Mendelian أو يعني الـ familial و الـ inherited
+
+683
+00:58:56,790 --> 00:59:03,330
+forms of tumors و cancer وأحياناً Sporadic المثال
+
+684
+00:59:03,330 --> 00:59:07,950
+يعني Retinoblastomas الـ Retinoblastomas أحياناً
+
+685
+00:59:07,950 --> 00:59:13,060
+بيكونفاميليا، يعني تلاقيه موجودة في العائلة،
+
+686
+00:59:13,060 --> 00:59:32,620
+وفـ’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’
+
+687
+00:59:35,280 --> 00:59:41,100
+بالنسبة لـ Mendelian type of inheritance بتكون الـ
+
+688
+00:59:41,100 --> 00:59:44,760
+suggestive أو الـ very clear single mutation
+
+689
+00:59:44,760 --> 00:59:49,280
+وبالتالي هنا مثلا autosomal dominant males و
+
+690
+00:59:49,280 --> 00:59:52,960
+females و كل ال generation مصابين فبالتالي هذه
+
+691
+00:59:52,960 --> 00:59:57,200
+autosomal dominant mutation
+
+692
+00:59:57,200 --> 01:00:04,980
+والنتيجة أن الـ tumors usually are multipleيعني في
+
+693
+01:00:04,980 --> 01:00:10,500
+حالة الـDNA repair برضه mutation بيكون فيه skin
+
+694
+01:00:10,500 --> 01:00:14,760
+cancer وبيكون muscle cancer وبيكون كده بتلاقي
+
+695
+01:00:14,760 --> 01:00:19,060
+الـTumor في أكثر من محل وتكون bilateral وتكون
+
+696
+01:00:19,060 --> 01:00:26,460
+early onset طبعاً إذا early onset وaffects life
+
+697
+01:00:26,460 --> 01:00:31,730
+بشكل واضحفي الغالب ما راح تقدر العائلة تكمل
+
+698
+01:00:31,730 --> 01:00:37,390
+ويتكونوا هيك يعني المصاب ما vintage يعني بس يعني
+
+699
+01:00:37,390 --> 01:00:42,510
+هاي الـ الـ الـ characteristics that tells you
+
+700
+01:00:42,510 --> 01:00:48,030
+that this mutation in the germ line أو in in يعني
+
+701
+01:00:48,030 --> 01:00:52,230
+is a Mendelian type of inheritance type of cancer
+
+702
+01:00:52,230 --> 01:00:58,660
+causation في الـ sporadicفي الغالب Single Tumors،
+
+703
+01:00:58,660 --> 01:01:03,280
+Unilateral، Later Onset ويكون Somatic Mutation
+
+704
+01:01:03,280 --> 01:01:08,280
+Multiple وبتيجي بعدين في الحياة لحيث إنه شخص واحد
+
+705
+01:01:08,280 --> 01:01:12,740
+هو المصاب والبقية مش مصابة فأحياناً بعض السرطانات
+
+706
+01:01:12,740 --> 01:01:17,740
+بتلاقيها إما Sporadic أو Familial أو Inherited
+
+707
+01:01:17,740 --> 01:01:22,660
+ويكون يعني اللي بدي استنتج الواحد من هذا الكلام
+
+708
+01:01:22,660 --> 01:01:28,240
+إنه في هذه الحالة المندليانالـ effect of that
+
+709
+01:01:28,240 --> 01:01:31,800
+single mutation is very powerful is much stronger
+
+710
+01:01:31,800 --> 01:01:38,420
+than المطلوب وبتكون هنا من الـ germline mutation
+
+711
+01:01:38,420 --> 01:01:42,660
+وهنا بدأنا بـ normal gene وصار عندي somatic
+
+712
+01:01:42,660 --> 01:01:46,880
+mutation بدأنا هنا germline mutation وادتني إشي
+
+713
+01:01:46,880 --> 01:01:53,120
+تاني صوتها بزيادة وخبصت المعضلةهدولة يعني برضه من
+
+714
+01:01:53,120 --> 01:01:59,720
+الطواهر اللي بتحدث وبتكون موجودة الـ two slides
+
+715
+01:01:59,720 --> 01:02:06,580
+هدولة بيعطونا فكرة وهو دليل على إنه السرطانات is
+
+716
+01:02:06,580 --> 01:02:15,560
+in part is familial أو is genetic فيه variation في
+
+717
+01:02:15,560 --> 01:02:24,970
+الـ riskعلى كل نوع من الحرارة في عائلة معينة يعني
+
+718
+01:02:24,970 --> 01:02:33,150
+هنا بالأول هنا one parent اللي affected ب certain
+
+719
+01:02:33,150 --> 01:02:39,030
+cancer يعني if one parent is affected مثلا cancer
+
+720
+01:02:39,030 --> 01:02:46,380
+of the testicles almost five timesالإنسان إذا واحد
+
+721
+01:02:46,380 --> 01:02:50,500
+أبوه صار عنده سرطان الخصية يصير هو عنده سرطان
+
+722
+01:02:50,500 --> 01:02:54,700
+الخصي كمان five times more than the average
+
+723
+01:02:54,700 --> 01:03:02,820
+population البقية برضه فيها نسبة أقل بالنسبة
+
+724
+01:03:02,820 --> 01:03:08,000
+إلى إذا فيه sibling يعني أخ أو أخت أقوى سرطان ممكن
+
+725
+01:03:08,000 --> 01:03:11,780
+الإنسان يصيبه
+
+726
+01:03:11,780 --> 01:03:17,010
+هو thyroid gland cancerيعني تقريبًا 15 مرة أكتر من
+
+727
+01:03:17,010 --> 01:03:22,210
+عادة اللي هو الـ Standardized Incidence Ratio ‏for
+
+728
+01:03:22,210 --> 01:03:29,450
+cancer فالفكرة إذا الإنسان عنده Relatives أو
+
+729
+01:03:29,450 --> 01:03:33,050
+Relatives with certain types of cancer you can
+
+730
+01:03:33,050 --> 01:03:37,590
+appreciate that they can have increased risk for
+
+731
+01:03:37,590 --> 01:03:40,850
+cancer and part of this is because of shared
+
+732
+01:03:40,850 --> 01:03:46,700
+genetics بس كمان بيظل عنديمبدأ إنه ممكن الـ
+
+733
+01:03:46,700 --> 01:03:48,180
+«إنكريزد ريسك» «إنكريزد ريسك» «إنكريزد ريسك»
+
+734
+01:03:48,180 --> 01:03:48,740
+«إنكريزد ريسك» «إنكريزد ريسك» «إنكريزد ريسك»
+
+735
+01:03:48,740 --> 01:03:49,500
+«إنكريزد ريسك» «إنكريزد ريسك» «إنكريزد ريسك»
+
+736
+01:03:49,500 --> 01:03:52,980
+«إنكريزد ريسك» «إنكريزد ريسك» «إنكريزد ريسك»
+
+737
+01:03:52,980 --> 01:03:53,880
+«إنكريزد ريسك» «إنكريزد ريسك» «إنكريزد ريسك»
+
+738
+01:03:53,880 --> 01:04:05,360
+«إنكريزد ريسك» «إنكريزد ريسك» «إنكريزد
+
+739
+01:04:05,360 --> 01:04:12,920
+ريسك
+
+740
+01:04:13,420 --> 01:04:20,600
+يعني يمكن تقريبًا أربعين أو خمسين سنة فيه بالذات
+
+741
+01:04:20,600 --> 01:04:26,360
+مرض أو سرطان الدم اللي هو «CML» اللي بيسموه
+
+742
+01:04:26,360 --> 01:04:32,520
+«Chronic Myeloid Leukemia» سرطان الدم من نوعي معين
+
+743
+01:04:32,520 --> 01:04:38,520
+وهو سرطان بطيء ومزمن فهو «Chronic Myeloid
+
+744
+01:04:38,520 --> 01:04:45,740
+Leukemia» «CML»لاحظنا فيهم هدولة كمثال على الـ
+
+745
+01:04:45,740 --> 01:04:51,980
+كمثال على الـ Genetic Anomaly أنه فيه عندهم إشي
+
+746
+01:04:51,980 --> 01:04:55,960
+اسمه Philadelphia chromosome بالذات هذا السرطان
+
+747
+01:04:55,960 --> 01:05:00,580
+يعني راح نتكلم عنه لأنه فيه أشياء specific إله
+
+748
+01:05:00,580 --> 01:05:15,710
+أكتر يعني محددة أكتر وبتكون يعنياللي بتكون ال ..
+
+749
+01:05:15,710 --> 01:05:21,790
+يعني راح نحكي له عن نوع من العلاج له نتيجة فهمنا
+
+750
+01:05:21,790 --> 01:05:29,870
+للـ Pathogenesis تبع الـ Disease فيه
+
+751
+01:05:29,870 --> 01:05:37,520
+Two Genesواحد اسمه الـ B-cell receptor اللي هو PCR
+
+752
+01:05:37,520 --> 01:05:40,940
+يعني الـ Associated Protein with the B-cell
+
+753
+01:05:40,940 --> 01:05:43,460
+receptor اللي تبع الـ Immunoglobulin بس هو مش الـ
+
+754
+01:05:43,460 --> 01:05:49,000
+Immunoglobulin هو أنا في إيش ذبوب PCR فالـ PCR هذا
+
+755
+01:05:49,000 --> 01:05:55,560
+موجود على كرمزوم 22 وفي another gene برضه related
+
+756
+01:05:55,560 --> 01:06:03,170
+to theالـ Hematologic Series أو الـ Blood Cell الـ
+
+757
+01:06:03,170 --> 01:06:10,550
+White وحتى الـ Red Blood Cell على كرومزوم 9 اسمه
+
+758
+01:06:10,550 --> 01:06:15,430
+ABL-1 فالذين
+
+759
+01:06:15,430 --> 01:06:19,970
+لاحظوا من الأول وحتى قبل ما يفهموا ليش الأمر بتم
+
+760
+01:06:19,970 --> 01:06:27,340
+في الـCML بهذا الشكلإنه لدي لقوا Translocation
+
+761
+01:06:27,340 --> 01:06:36,640
+يعني فيه segment من كروموزوم 22 هذه الـ long arm
+
+762
+01:06:36,640 --> 01:06:43,820
+انتحار بتيجي وبتشبك على كروموزوم 9 قريبة بين هذه
+
+763
+01:06:43,820 --> 01:06:47,580
+بحيث اللي لقوا إن اللي عندهم هذا النوع من السرطان
+
+764
+01:06:47,580 --> 01:06:55,100
+الـ mutation عندهم إنه بيصير عندي Translocationزي
+
+765
+01:06:55,100 --> 01:07:00,600
+الـ Chromosome 22 على الـ Chromosome 9 وبتصير عندي
+
+766
+01:07:00,600 --> 01:07:10,720
+بيقرب الـ VCR على الـ AVL1 فالـ VCR AVL1 هو
+
+767
+01:07:10,720 --> 01:07:16,820
+البروتين الجديد الـ Product تبعه ولأنه دخل بالـ
+
+768
+01:07:16,820 --> 01:07:21,900
+VCR يعني بالـ B Cell Surface Receptor بيخلّي أنه
+
+769
+01:07:21,900 --> 01:07:28,480
+بيخرّبالخلايا الدم بحيث إنه بيكون نوع من السلطنات
+
+770
+01:07:28,480 --> 01:07:33,380
+محدد أو بشكل معين، اسمه الـCML ويكون عندي
+
+771
+01:07:33,380 --> 01:07:37,780
+Translocation بين أدولة الـTwo Points والنتيجة إن
+
+772
+01:07:37,780 --> 01:07:45,720
+الـABL1 جين والبروتين تبعه يصير يشبك مع الـPCR
+
+773
+01:07:48,160 --> 01:07:53,660
+جين وبروتين حيث تصير عندك نوتاتجين أو نوتاتج
+
+774
+01:07:53,660 --> 01:07:57,980
+بروتين بتطلع وهو اللي بيظن إنه بيخلّي الخلايا ما
+
+775
+01:07:57,980 --> 01:08:02,720
+تموت وبيخلّي السرطان يتشوّر فهذا هو
+
+776
+01:08:02,720 --> 01:08:08,140
+الـPhiladelphia Chromosome هو لـ«ماليقننسية
+
+777
+01:08:08,140 --> 01:08:12,540
+كينيطولوجية» من نوع معين أحياناً حتى بيساعدنا إنه
+
+778
+01:08:12,540 --> 01:08:18,900
+نتشخّص شو نوعية الخلية اللي عاملة المشكلةوفي عندها
+
+779
+01:08:18,900 --> 01:08:22,820
+هذه الاشياء وهذه كمان ملاحظة في كتير من الـ
+
+780
+01:08:22,820 --> 01:08:27,640
+hematologic malignancies أحنا هاي البركة الليمبومة
+
+781
+01:08:27,640 --> 01:08:31,280
+acute lymphoplastic leukemia acute lymphoplasty
+
+782
+01:08:31,280 --> 01:08:36,640
+اللي فيه more than for acute lymphoplastic acute
+
+783
+01:08:36,640 --> 01:08:42,120
+promyelocytic اللي قابلني ALL7A3
+
+784
+01:08:42,120 --> 01:08:46,640
+لـpromyelocytic أو chronic lymphocytic leukemiaأو
+
+785
+01:08:46,640 --> 01:08:50,360
+Follicular lymphoma أو Burkitt lymphoma طبعاً يعني
+
+786
+01:08:50,360 --> 01:08:53,580
+المبدأ
+
+787
+01:08:53,580 --> 01:08:57,860
+الأساسي يجب أن تتذكروا كلمة leukemia يعني سرطان في
+
+788
+01:08:57,860 --> 01:09:02,700
+الدم لما نفس الخلايا بتكون لسه بالـ lymph node
+
+789
+01:09:02,700 --> 01:09:07,840
+وموصة الدم نسميها lymphoma ففي Burkitt، Hodgkin،
+
+790
+01:09:07,840 --> 01:09:11,220
+Non-Hodgkin الـBurkitt هو من نوع من الـNon-Hodgkin
+
+791
+01:09:11,220 --> 01:09:15,630
+lymphoma فسهم كلهم نفس الخلاياودولة بيكون عندي
+
+792
+01:09:15,630 --> 01:09:23,030
+Translocation وفي تفاوت بالـ percentages الـ cases
+
+793
+01:09:23,030 --> 01:09:29,670
+و الـ affected proto-oncogene affected الـ PCR
+
+794
+01:09:29,670 --> 01:09:33,150
+ABL1 اللي هو الفلادلفيا البروميزوم وموجود في أكتر
+
+795
+01:09:33,150 --> 01:09:40,730
+منها اللي بدي أكم تتذكرون منه هو تبع الـ CML هذا
+
+796
+01:09:40,730 --> 01:09:50,000
+موجود 95% منالـ «CML» وبكون بالشكل اللي حكيناه
+
+797
+01:09:50,000 --> 01:09:53,300
+طبعاً يعني كمان النقطة التانية اللي واحد ينتبه
+
+798
+01:09:53,300 --> 01:09:59,600
+إلها لما هم يرسميكم إياها هنا إنه «Which test I
+
+799
+01:09:59,600 --> 01:10:04,300
+should use to diagnose this translocation»
+
+800
+01:10:04,300 --> 01:10:07,500
+«translocation» يعني قطعة كبيرة أحنا ما بنتكلم عن
+
+801
+01:10:07,500 --> 01:10:11,530
+الـ mutation زي single nucleotide polymorphismالـ
+
+802
+01:10:11,530 --> 01:10:15,050
+«سنب» أو الـ «مايكروسيتالايت» أو الأشياء الصغيرة
+
+803
+01:10:15,050 --> 01:10:19,790
+هذه قطعة، شنقة كويسة، كبيرة فبالتالي أنا لازم أعمل
+
+804
+01:10:19,790 --> 01:10:24,510
+«Caryotype» هنا بنعمل الـ «Chromosome
+
+805
+01:10:24,510 --> 01:10:29,230
+Translocation» نعملها Translocation حتى نفحصها
+
+806
+01:10:29,230 --> 01:10:33,890
+نفحص من خلال الـ «Caryotype» وبلاغي هذه الأنواع
+
+807
+01:10:33,890 --> 01:10:39,030
+نتذكر الـ «CML» والفرديل فيها Chromosome اللي
+
+808
+01:10:39,030 --> 01:10:48,530
+بيصير عنديTranslocation بين كرمزوم 9 و22 بالـ9،
+
+809
+01:10:48,530 --> 01:10:55,790
+الـQ هو 34 وبالـ22، الـQ هو 11 الـSegment بتبعات
+
+810
+01:10:55,790 --> 01:11:02,030
+الـDNA أو بتبعات الكرمزوم حتى يصير هذه المشكلة
+
+811
+01:11:02,030 --> 01:11:10,290
+وافتشفنا بعدين إن الـPCR-ABL-1 Joining هو اللي له
+
+812
+01:11:10,290 --> 01:11:16,980
+مشكلةوبعمل المشكلة باقية الأشياء ما تحصلوا آخر
+
+813
+01:11:16,980 --> 01:11:30,440
+سلايدين يعني بتكلم عن أو آخر موضوعين بدنا
+
+814
+01:11:30,440 --> 01:11:37,880
+نحاول نفهم كيف باكتشف أنه جين هو اللي عمل المشكلة
+
+815
+01:11:37,880 --> 01:11:47,210
+الموضوع هذابكون من خلال دراسة عدد كبير من الجينات
+
+816
+01:11:47,210 --> 01:11:54,830
+والدراسة ممكن يكون لها أكتر من طريقة الـSNP
+
+817
+01:11:54,830 --> 01:12:01,190
+والـSequencing بالـPCR وغيره بكون من خلال
+
+818
+01:12:01,190 --> 01:12:07,670
+Sequencing وأقرأ الـNucleotides وأحاول أشوف
+
+819
+01:12:07,670 --> 01:12:12,580
+الـVariation فيها أحيانًافي الطريقة الثانية حتى
+
+820
+01:12:12,580 --> 01:12:21,080
+أستنتج إن صار في خلل الجين إن أشوف أنه جينات صار
+
+821
+01:12:21,080 --> 01:12:24,660
+إلها activation أكتر وأنه جينات صار إلها
+
+822
+01:12:24,660 --> 01:12:29,220
+activation أقل يعني أنا بدرسها بطريقة مختلفة أنا
+
+823
+01:12:29,220 --> 01:12:35,600
+هنا ما بدرس نفس تركيب الـCoding Gene وشو هو فيه
+
+824
+01:12:35,600 --> 01:12:40,710
+مشكلة أنا بحاول أدرس كامهذا الـ gene اشتغل وكم
+
+825
+01:12:40,710 --> 01:12:48,270
+النسخ تبعته فالـ الـ الـ الـ حتى ينجح بهذا الأمر
+
+826
+01:12:48,270 --> 01:12:55,990
+أول شيء لازم يكون عندي good sample from يعني
+
+827
+01:12:55,990 --> 01:13:01,950
+controls and affected people يعني في الغالب هذه
+
+828
+01:13:01,950 --> 01:13:06,590
+الشيء بقدر أتحثها على عائلة عندي مجموعة أفراد فيها
+
+829
+01:13:07,040 --> 01:13:11,020
+زي مثلًا حكينا ثمين للـ Retinoplastoma أو لا إشي
+
+830
+01:13:11,020 --> 01:13:16,300
+أو أنا أجيب مجموعة مصابين بسرطان معين مثلًا
+
+831
+01:13:16,300 --> 01:13:20,940
+Thyroid Cancer أو CML أو أي نوع Cancer وأجيب
+
+832
+01:13:20,940 --> 01:13:25,180
+مجموعة مصابين وأكون أنا عارف الـStandard
+
+833
+01:13:27,610 --> 01:13:35,170
+شو اسمه؟ عارف الـ Standard Result تبع الفشر
+
+834
+01:13:35,170 --> 01:13:40,230
+العاديين مجموعة أخرى طبيعية مش مصابية طريقة
+
+835
+01:13:40,230 --> 01:13:45,610
+الدراسة هنا اللي بيسموها Expression Profiling يعني
+
+836
+01:13:45,610 --> 01:13:52,810
+بالأخير أنا بقيس كام نسخ الـ RNA على مستوى الـ RNA
+
+837
+01:13:52,810 --> 01:14:00,830
+أحياناًأو مستوى البروتين كده اندي بروتين ناتج في
+
+838
+01:14:00,830 --> 01:14:08,770
+هذه الخلايا تبع هذه المجموعة وهذه المجموعة طريقة
+
+839
+01:14:08,770 --> 01:14:17,350
+القراءة، فانت هنا الجهاز هذا، الدراسة هذه في هذه
+
+840
+01:14:17,350 --> 01:14:22,710
+الـStudies Specifically درسوا عن حوالي 100 جيون
+
+841
+01:14:23,590 --> 01:14:31,970
+طبعًا هذه الصفات اللي يعني نعتبرها الـ «جديدة
+
+842
+01:14:31,970 --> 01:14:38,290
+التكنولوجيا» لتعمل الدراسات اللي هي إنه أنا عند
+
+843
+01:14:38,290 --> 01:14:42,070
+الآلة قوي جدًا زي كمبيوتر سريق جدًا زي جوجل هيك،
+
+844
+01:14:42,070 --> 01:14:47,770
+بتحطله كلمتين بتجيبك البحث خلال واحد بالمئة من
+
+845
+01:14:47,770 --> 01:14:54,310
+التاني وكذا فهي أدوات قوية جدًاوهنا أنا بفحص سواء
+
+846
+01:14:54,310 --> 01:14:58,290
+على مستوى الـ RNA أو البروتين على الـ Gene
+
+847
+01:14:58,290 --> 01:15:04,170
+Expression فأنا هنا أخدت 100 جين بحاول أدرسهم
+
+848
+01:15:04,170 --> 01:15:10,530
+وأشوف درجة الـ Expression تبعت الجين هذا الـ
+
+849
+01:15:10,530 --> 01:15:15,670
+Expression تبعه بدي تكون RNA أو بروتين بالأخير راح
+
+850
+01:15:15,670 --> 01:15:21,430
+أحصل for individual sample نقط بدي تكون بهذا الشكل
+
+851
+01:15:22,110 --> 01:15:27,770
+لما يكون أصفر معناته هذا الـ gene الـ expression
+
+852
+01:15:27,770 --> 01:15:33,610
+تبعه زيه زي الـ normal person إذا حاطين أخضر أحمر
+
+853
+01:15:33,610 --> 01:15:39,850
+بالأول معناته إنه هذا الـ expression تبعه قلب بطل
+
+854
+01:15:39,850 --> 01:15:45,790
+يكون منه وبالنسبة لأخضر معناته الـ expression
+
+855
+01:15:45,790 --> 01:15:52,010
+level أكبر فهنا زي ما هم حاطينك هناto a reference
+
+856
+01:15:52,010 --> 01:15:58,610
+expression profile طبعاً يعني لو أنا جيت بدي أشوف
+
+857
+01:15:58,610 --> 01:16:04,130
+مثل هذه الأشياء ممكن لو أخد لنفس الإنسان وهيسووها
+
+858
+01:16:04,130 --> 01:16:08,970
+لنفس الإنسان tissues from different sites أو
+
+859
+01:16:08,970 --> 01:16:12,800
+organsأنا باخده من العضلات شوية من الجلد شوية من
+
+860
+01:16:12,800 --> 01:16:18,160
+الدم شوية من الـ GI tract من كده من كده و أشوف أيش
+
+861
+01:16:18,160 --> 01:16:21,060
+الدينات اللي بتشتغل أكتر و أيش الدينات اللي بتبطل
+
+862
+01:16:21,060 --> 01:16:27,220
+أكتر فأنا عندي ثماني individuals بصفهم بهذا الشكل
+
+863
+01:16:27,220 --> 01:16:32,380
+يعني أنا الـresult لكل واحد بتكون بهذا الشكل و
+
+864
+01:16:32,380 --> 01:16:38,040
+بعدين بصفهم هنا ثمان أفراد بالـMeat Gene اللي أنا
+
+865
+01:16:38,040 --> 01:16:45,510
+درستهموبعدين أنا بقسم بعدين النتائج ليعني بالأخير
+
+866
+01:16:45,510 --> 01:16:54,050
+بهمني شو المجموعة اللي مجموعة الجينات اللي يعني
+
+867
+01:16:54,050 --> 01:16:58,830
+صار لها over expression ومجموعة الجينات اللي صار
+
+868
+01:16:58,830 --> 01:17:04,430
+لها under expression فهنا كمثال يعني hypothetical
+
+869
+01:17:04,430 --> 01:17:11,250
+افتراضيإنه أنا بس جيت درست الموضوع هذا كان عندي
+
+870
+01:17:11,250 --> 01:17:15,690
+مثلا tumor A من المجموعة الـ Individual اللي عندهم
+
+871
+01:17:15,690 --> 01:17:19,490
+كان tumor A و tumor B وقارنت بينهم أو ممكن حطوا
+
+872
+01:17:19,490 --> 01:17:22,890
+طبعاً بالأول بيكونوا حاطين الـ Background أو الأصل
+
+873
+01:17:22,890 --> 01:17:29,190
+اللي هو الـ Normal فأنا راح ألاقي إنه المجموعة هذه
+
+874
+01:17:29,190 --> 01:17:33,930
+certain genes هذه بالزاوية هذه بيكون much higher
+
+875
+01:17:33,930 --> 01:17:41,710
+in A than in Bويعني هنا دول المجموعة الـA
+
+876
+01:17:41,710 --> 01:17:46,270
+الـExpression تبعهم أخضر لهذه الجينات جين 1، جين
+
+877
+01:17:46,270 --> 01:17:53,310
+25 و27 بحدد أي جينات اللي هنا وهنا أقل مجموعة
+
+878
+01:17:53,310 --> 01:17:58,090
+بالنسبة للـTumor B أقل من إتريا هنا بتصير قل
+
+879
+01:17:58,090 --> 01:18:03,870
+وبعدين هنا مجموعة الجينات هذه شغالة أكتر كثير عند
+
+880
+01:18:03,870 --> 01:18:09,430
+اللي عندهم Type B tumorوأكتر من الـ Type A الجينات
+
+881
+01:18:09,430 --> 01:18:13,990
+هذه بشوف درجة اللي لو كان عندي عدد بشوف قوة
+
+882
+01:18:13,990 --> 01:18:18,410
+الارتباط بين expression over expression أو under
+
+883
+01:18:18,410 --> 01:18:21,310
+expression of certain gene to any type of cancer
+
+884
+01:18:21,310 --> 01:18:26,250
+هدولة يعني من الدراسات اللي ممكن تعمل تعتمد على
+
+885
+01:18:26,250 --> 01:18:31,830
+تقنيات حديثة تعتمد على إنه أنا أجيب عينات مناسبة
+
+886
+01:18:32,390 --> 01:18:36,650
+أقدر أقارن بينهم سواء الـ «تجارب مختلفة» «تجارب
+
+887
+01:18:36,650 --> 01:18:41,390
+مختلفة» «تجارب مختلفة» «تجارب مختلفة» «تجارب
+
+888
+01:18:41,390 --> 01:18:43,570
+مختلفة» «تجارب مختلفة» «تجارب مختلفة» «تجارب
+
+889
+01:18:43,570 --> 01:18:43,590
+مختلفة» «تجارب مختلفة» «تجارب مختلفة» «تجارب
+
+890
+01:18:43,590 --> 01:18:43,750
+مختلفة» «تجارب مختلفة» «تجارب مختلفة» «تجارب
+
+891
+01:18:43,750 --> 01:18:44,010
+مختلفة» «تجارب مختلفة» «تجارب مختلفة» «تجارب
+
+892
+01:18:44,010 --> 01:18:44,770
+مختلفة» «تجارب مختلفة» «تجارب مختلفة» «تجارب
+
+893
+01:18:58,620 --> 01:19:03,060
+واللي مثلًا كله أصفر بالباقية معناته لأ ما كان إله
+
+894
+01:19:03,060 --> 01:19:08,260
+دخله ما إله كان إله دور يعني هاي الأشياء بتكون
+
+895
+01:19:08,260 --> 01:19:16,280
+بأذا الشكل هنا بنفس الطريقة يعني هاي على نفس
+
+896
+01:19:16,280 --> 01:19:21,740
+المبدأ اللي شفناها قبل شوية
+
+897
+01:19:29,310 --> 01:19:35,570
+هذه الأنواع من الدراسات صراحة يعني معقدة جدا
+
+898
+01:19:35,570 --> 01:19:40,990
+وللأسف يعني أحياناً كتيرة حتى لو بحاول أقراها في
+
+899
+01:19:40,990 --> 01:19:46,150
+مجلات علمية وبحاول أرجع للـ Original Data مرات
+
+900
+01:19:46,150 --> 01:19:51,110
+كتير بتكون غير مفهومة بشكل قوي وبالتالي يعني
+
+901
+01:19:51,110 --> 01:19:58,250
+بتخربط الواحد اللي بدهم يحكوه هناإنه حتى يثبتوا
+
+902
+01:19:58,250 --> 01:20:06,490
+إنه والله الجين الإفلاني هو المهم وهو اللي يعني
+
+903
+01:20:06,490 --> 01:20:09,690
+اللي
+
+904
+01:20:09,690 --> 01:20:18,890
+له دور أكبر أحيانًا من يعني طريقة المتابعة للمرضى
+
+905
+01:20:21,460 --> 01:20:24,820
+إنه أنا أربط الموضوع هذا بالنسبة للـGene
+
+906
+01:20:24,820 --> 01:20:32,140
+Expression مع الـSurvivor يعني أنا عندي الآن مثلا
+
+907
+01:20:32,140 --> 01:20:38,720
+ميت مريض lung cancer نفترض هيك وأخدت بالـDiagnosis
+
+908
+01:20:38,720 --> 01:20:44,820
+lung cancer وجيت بعدين عملت نوع من الدراسة زي هذه
+
+909
+01:20:45,490 --> 01:20:51,670
+بتورت أشوف اجدرت بطريقة معينة أنه أخليهم cluster
+
+910
+01:20:51,670 --> 01:21:00,850
+يعني يكون مجموعة يعني ممكن نوعية معينة مثلا إشي
+
+911
+01:21:00,850 --> 01:21:05,070
+مميز لها فأهمية
+
+912
+01:21:05,070 --> 01:21:10,310
+الـ Gene بالذات على الـ pathogenesis على الـ
+
+913
+01:21:10,310 --> 01:21:15,390
+Prognosis على إذا أحيانًا Treatment Modalityإنه
+
+914
+01:21:15,390 --> 01:21:20,490
+أنا يعني هنا نوع دراسي تاني مختلفة إنه بعد ما عرفت
+
+915
+01:21:20,490 --> 01:21:25,690
+إنه أنا قسمت الخلايا أو قسمت الـ Sample إنه هدولة
+
+916
+01:21:25,690 --> 01:21:30,210
+مجموعة عندهم certain genes هم اللي مش شغلات و
+
+917
+01:21:30,210 --> 01:21:33,070
+certain genes هم الشغلات على العكس الـCluster B
+
+918
+01:21:33,820 --> 01:21:40,060
+بلاقي إنه بعدين تابعت المرضى هذولة وخصوصاً هنا
+
+919
+01:21:40,060 --> 01:21:43,140
+الحالة بقاعي بالـ months على كلامهم يعني هنا
+
+920
+01:21:43,140 --> 01:21:47,360
+تابعوا المرضى عشر سنين زي الـCML أو الـprostate
+
+921
+01:21:47,360 --> 01:21:51,960
+cancer هذولة cancer ولو إنهم cancer بس بطيل وبعض
+
+922
+01:21:51,960 --> 01:21:56,100
+أنواع السرطانات هيك فنتج عن الأمر هذا إنه أنا
+
+923
+01:21:56,100 --> 01:22:01,400
+لاحظتإن اللي عندهم بهذا الشكل لأ والله شغلهم أحسن
+
+924
+01:22:01,400 --> 01:22:05,580
+يعني أنا هنا ما بكون aggressive ما بكون هذا هذا
+
+925
+01:22:05,580 --> 01:22:10,440
+المريض بروستيت كانسر والله مرات كتير بحكي و بقول
+
+926
+01:22:10,440 --> 01:22:14,580
+الأهل المرضى هو مرضى إذ ذات كبير بالعمر و عنده
+
+927
+01:22:14,580 --> 01:22:19,860
+نوعية بطيقة بقوله يمكن لو علجناه نذبحه أسرع نقتل
+
+928
+01:22:19,860 --> 01:22:27,340
+المريض أسرع من إنسان تركناه لحالهفهنا بثبتوا إنها
+
+929
+01:22:27,340 --> 01:22:34,340
+Two clusters by the gene expression واستفدت منها
+
+930
+01:22:34,340 --> 01:22:38,480
+إنه اللي عنده الـCluster A لازم يكون Aggressive
+
+931
+01:22:38,480 --> 01:22:42,740
+لأن هذا الإنسان راح يكون الـPrognosis تبعه Bad،
+
+932
+01:22:42,740 --> 01:22:46,460
+Poor، على العكس لو كان على الـCluster B وهي فائدة
+
+933
+01:22:46,460 --> 01:22:49,960
+لهذا النوع من الدراسات الـLong Term Survival
+
+934
+01:22:49,960 --> 01:22:57,730
+النقطة الأخيرةإنه يعني حتى في مفهوم قضية إن كل
+
+935
+01:22:57,730 --> 01:23:01,510
+خلية لازم يكون لها كل نوع من الخلايا لازم يكون لها
+
+936
+01:23:01,510 --> 01:23:05,430
+نوع معدد من الـ Transcription Factor من Certain
+
+937
+01:23:05,430 --> 01:23:12,370
+Signals Signal Transduction فهذه أنتجت إنه صار
+
+938
+01:23:12,370 --> 01:23:17,210
+عندي أنواع كتير من الأدوية اللي بتحاول تخرّب أو
+
+939
+01:23:17,210 --> 01:23:25,940
+تنشط مرات Certain Signal Transductionفهدولة يعني
+
+940
+01:23:25,940 --> 01:23:30,140
+نسميهم «Tyrosine Kinase Inhibitor» أحيانًا
+
+941
+01:23:30,140 --> 01:23:36,620
+«Activator» بس يعني «Tyrosine Kinase» يعني
+
+942
+01:23:36,620 --> 01:23:46,120
+«Inhibitor» أو أحيانًا «Modifier» أو كده ففيه
+
+943
+01:23:46,120 --> 01:23:49,580
+الآن طالع عندي مجموعة «Cancer Treatments Targeted
+
+944
+01:23:49,580 --> 01:23:53,140
+to Specific Activated Driver Oncogenes»
+
+945
+01:23:56,310 --> 01:24:04,410
+الأدوية اسمها كتير فإحنا بس بدي منكم اثنين الـ
+
+946
+01:24:04,410 --> 01:24:14,350
+Imatinib اللي هو نسيت اسمه نسيت Imatinib في لسن
+
+947
+01:24:14,350 --> 01:24:21,870
+تجاري مشهور جدا بس راح انبالي هذا عبارة عن يعني
+
+948
+01:24:21,870 --> 01:24:27,350
+بالذات للـ CMLيعني قريب بدخل في زي ما حكينا
+
+949
+01:24:27,350 --> 01:24:35,850
+الفلاجينفيا chromosome هذا عبارة عن يعني drug very
+
+950
+01:24:35,850 --> 01:24:43,850
+specific to the myeloid series ونتيجته إنه كأنه
+
+951
+01:24:43,850 --> 01:24:49,170
+الـ Apoptosis تبع الخلايا بوقّط الـCMLهو بتجبر
+
+952
+01:24:49,170 --> 01:24:54,570
+الخلايا تظل تنقسم وتكمل هو Specific Inhibitor of
+
+953
+01:24:54,570 --> 01:25:00,550
+Tyrosine Kinase الـNIP إذا بتنتبهوا عليها بالأخير
+
+954
+01:25:00,550 --> 01:25:07,710
+هاي اللي هما الأسماء تبعات الـInhibitors of
+
+955
+01:25:07,710 --> 01:25:13,530
+Tyrosine Kinase الـNIPS دولة فـGifety-NIP، Matty
+
+956
+01:25:13,530 --> 01:25:17,810
+-NIP، Milton-NIP ومش عارف دستاني-NIPالذول إذا
+
+957
+01:25:17,810 --> 01:25:22,250
+بتشوف إشي زي هيك اسمه بالأخير هذا Inhibitor of a
+
+958
+01:25:22,250 --> 01:25:26,970
+Certain Tyrosine Kinase وبصير يعني نتيجة بدأ الأمر
+
+959
+01:25:26,970 --> 01:25:30,950
+إنه أنا أول شي درست الـGene ودرست الـ… هو
+
+960
+01:25:30,950 --> 01:25:34,890
+الـOncogene أو Driver Oncogene وشبت الـSignal
+
+961
+01:25:34,890 --> 01:25:39,450
+Transaction تبعه أنه Tyrosine Kinase صرت أجيب أدوي
+
+962
+01:25:39,450 --> 01:25:43,030
+ومركبات وأشياء أشوف مين اللي بيطبط هذا الـTyrosine
+
+963
+01:25:43,030 --> 01:25:48,660
+Kinase وطلعوا مجموعة أدوي كبيرةفهذه الآن يعني هي
+
+964
+01:25:48,660 --> 01:25:54,040
+دراسة Targeted وهدولة كلهم من شركات أجرت دراسات
+
+965
+01:25:54,040 --> 01:25:59,640
+على السرطانات بهذا الشكل بتأخذ السرطان، بتعزل الـ
+
+966
+01:25:59,640 --> 01:26:04,360
+Thyrosinkinase تبعه بتحاول أن تتألف دواء ضد الـ
+
+967
+01:26:04,360 --> 01:26:09,380
+Thyrosinkinase فهذا مجموعة أدوية في أشياء كتيرة
+
+968
+01:26:09,380 --> 01:26:15,970
+أنا بس بطلب منكم الـ Imatinibاللي هو بالـ CML لأنه
+
+969
+01:26:15,970 --> 01:26:20,210
+فقعات جداً وكويس والـ side effects تبعه قليل يعني
+
+970
+01:26:20,210 --> 01:26:24,070
+إله major side effects بس نسبياً مش جد الكيموتراب
+
+971
+01:26:24,070 --> 01:26:28,290
+التاني و ال .. و ال .. يعني و الـ much better
+
+972
+01:26:28,290 --> 01:26:35,270
+tolerated أحسن الجروب التانية اللي هي بالأخير MAP
+
+973
+01:26:35,270 --> 01:26:42,830
+مثلًا Mplexigmap وغيرها اللي هو Trajectomapاللي هو
+
+974
+01:26:42,830 --> 01:26:50,150
+Amplified HER2-Gene في الـ Breast Cancer فالـ
+
+975
+01:26:50,150 --> 01:26:53,450
+Breast Cancer، الآن إحنا عندنا حتى في مستشفى الملك
+
+976
+01:26:53,450 --> 01:26:58,390
+المؤسس أي إمرأة أو إنسان، حتى ما يمكن نصيب الذكور
+
+977
+01:26:58,390 --> 01:27:04,390
+الـ Breast Cancer بإذا في حالة عندي HER2-Receptor
+
+978
+01:27:04,390 --> 01:27:09,630
+Positive نعطيه هذا الدواء، طبعا مشكلته الأنبول
+
+979
+01:27:09,630 --> 01:27:13,620
+الواحدة يبدو المريض مثلافي كل جرعة، انبولتين،
+
+980
+01:27:13,620 --> 01:27:19,380
+تلاتي، أربعة أحياناً بالألاف يعني all these drugs
+
+981
+01:27:19,380 --> 01:27:24,380
+are very extensive، very recent وفي شغل كتير عليهم
+
+982
+01:27:24,380 --> 01:27:30,000
+الـMAPS اللي هم الـMonoclonal Antibody ناشي، ويله
+
+983
+01:27:30,000 --> 01:27:33,920
+أنواعه المفروض تكونوا تعرفوا عنه من الـImmunology
+
+984
+01:27:33,920 --> 01:27:37,540
+في أحد عنده أسئلة؟ أي آخر slide؟
+
+985
+01:27:42,970 --> 01:27:47,890
+الله يعطيكم العافية وإن شاء الله إذا في أسئلة
+
+986
+01:27:47,890 --> 01:27:52,750
+للأسبوع القادم وبنكمل إن شاء الله الله يعطيكم
+
+987
+01:27:52,750 --> 01:27:57,370
+العافية ويذريكم الخير ونشوفكم الأسبوع اللي جاي
+
+988
+01:27:57,370 --> 01:28:01,390
+يعطيك ألف عافية دكتور الله يرضى عليك الله حييك
+
+989
+01:28:01,390 --> 01:28:03,950
+الله يكرمك سلام عليك برعاية الله
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/J6cZgtP3lRU_raw.json b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/J6cZgtP3lRU_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..b028526137762f614b7668cb29372e7d1984ec0c
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/J6cZgtP3lRU_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 2368, "start": 0.0, "end": 23.68, "text": "أربعة ‏so far ‏طيب احنا المحاضرة بتتسجل ‏وإن شاء الله يعني بالنسبة لكم نبدأ ‏وبالنسبة لزي ما حكينا كل مرة ‏أول شيء ده حد عنده أي أسئلة يعني", "tokens": [10721, 25513, 27884, 1059, 237, 539, 1400, 1059, 237, 9566, 1829, 3555, 1975, 5016, 8315, 9673, 5016, 46958, 25720, 39894, 2655, 3794, 7435, 1211, 1059, 237, 2407, 28814, 1863, 13412, 16606, 21984, 37495, 22653, 20666, 1863, 35457, 3660, 5296, 24793, 8717, 44510, 10721, 1059, 237, 37746, 6027, 1863, 35457, 3660, 5296, 11622, 1829, 19446, 11331, 4117, 1829, 8315, 28242, 3714, 25720, 1059, 237, 10721, 12610, 44049, 38207, 11778, 3224, 11331, 3215, 43242, 3224, 36632, 5551, 3794, 19986, 37977, 37495, 22653], "avg_logprob": -0.2349537095905822, "compression_ratio": 1.5590062111801242, "no_speech_prob": 4.76837158203125e-07, "words": [{"start": 0.0, "end": 0.68, "word": "أربعة", "probability": 0.804931640625}, {"start": 0.68, "end": 1.68, "word": " ‏so", "probability": 0.4953816731770833}, {"start": 1.68, "end": 2.14, "word": " far", "probability": 0.97607421875}, {"start": 2.14, "end": 3.36, "word": " ‏طيب", "probability": 0.725341796875}, {"start": 3.36, "end": 3.86, "word": " احنا", "probability": 0.7489420572916666}, {"start": 3.86, "end": 5.76, "word": " المحاضرة", "probability": 0.9766845703125}, {"start": 5.76, "end": 6.7, "word": " بتتسجل", "probability": 0.9587890625}, {"start": 6.7, "end": 7.84, "word": " ‏وإن", "probability": 0.5791748046875}, {"start": 7.84, "end": 8.06, "word": " شاء", "probability": 0.987548828125}, {"start": 8.06, "end": 8.4, "word": " الله", "probability": 0.9599609375}, {"start": 8.4, "end": 9.54, "word": " يعني", "probability": 0.697021484375}, {"start": 9.54, "end": 13.52, "word": " بالنسبة", "probability": 0.9381103515625}, {"start": 13.52, "end": 14.04, "word": " لكم", "probability": 0.831787109375}, {"start": 14.04, "end": 15.3, "word": " نبدأ", "probability": 0.9563802083333334}, {"start": 15.3, 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0.9735107421875}, {"start": 639.05, "end": 639.05, "word": " بيكونوا", "probability": 0.973388671875}, {"start": 639.05, "end": 639.07, "word": " بيكونوا", "probability": 0.9735107421875}, {"start": 639.07, "end": 656.47, "word": " بي", "probability": 0.97216796875}], "temperature": 1.0}, {"id": 27, "seek": 66626, "start": 662.0, "end": 666.26, "text": "بالنسبة للـ Cell Cycle وفيه Cell Proliferation", "tokens": [3555, 6027, 1863, 35457, 3660, 24976, 39184, 28859, 10295, 2160, 4032, 41185, 3224, 28859, 1705, 75, 44987], "avg_logprob": -0.19531250331136915, "compression_ratio": 0.9375, "no_speech_prob": 0.0, "words": [{"start": 662.0, "end": 663.12, "word": "بالنسبة", "probability": 0.88642578125}, {"start": 663.12, "end": 663.32, "word": " للـ", "probability": 0.91748046875}, {"start": 663.32, "end": 663.48, "word": " Cell", "probability": 0.73583984375}, {"start": 663.48, "end": 664.04, "word": " Cycle", "probability": 0.825927734375}, {"start": 664.04, "end": 664.66, "word": " وفيه", "probability": 0.6304524739583334}, {"start": 664.66, "end": 664.94, "word": " Cell", "probability": 0.91845703125}, {"start": 664.94, "end": 666.26, "word": " Proliferation", "probability": 0.9225260416666666}], "temperature": 1.0}, {"id": 28, "seek": 68856, "start": 667.56, "end": 688.56, "text": "لانقسام الخلايا أو تكاثر الخلايا فيه لـSignal معين إذا صار فيها mutation هنا ويكون فيها نوع من الـSpecific effect on cellular proliferation فإذا فيه Transcription factors إشي بيخلي certain gene become transcribed", "tokens": [1211, 7649, 4587, 3794, 10943, 33962, 15040, 25528, 34051, 6055, 4117, 5718, 104, 2288, 33962, 15040, 25528, 8978, 3224, 5296, 39184, 50, 788, 304, 20449, 9957, 11933, 15730, 20328, 9640, 8978, 11296, 27960, 34105, 4032, 1829, 30544, 8978, 11296, 8717, 45367, 9154, 2423, 39184, 19588, 22856, 1802, 322, 29267, 24398, 44987, 6156, 28814, 15730, 8978, 3224, 6531, 12432, 6771, 11933, 8592, 1829, 4724, 1829, 9778, 20292, 1629, 12186, 1813, 1145, 18732], "avg_logprob": 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0.89697265625}, {"start": 673.3, "end": 673.84, "word": " mutation", "probability": 0.37353515625}, {"start": 673.84, "end": 674.28, "word": " هنا", "probability": 0.9814453125}, {"start": 674.28, "end": 675.06, "word": " ويكون", "probability": 0.6824544270833334}, {"start": 675.06, "end": 675.74, "word": " فيها", "probability": 0.97607421875}, {"start": 675.74, "end": 677.34, "word": " نوع", "probability": 0.9638671875}, {"start": 677.34, "end": 677.6, "word": " من", "probability": 0.98876953125}, {"start": 677.6, "end": 678.7, "word": " الـSpecific", "probability": 0.74163818359375}, {"start": 678.7, "end": 679.1, "word": " effect", "probability": 0.41455078125}, {"start": 679.1, "end": 679.34, "word": " on", "probability": 0.71923828125}, {"start": 679.34, "end": 679.66, "word": " cellular", "probability": 0.82763671875}, {"start": 679.66, "end": 680.56, "word": " proliferation", "probability": 0.987060546875}, {"start": 680.56, "end": 681.6, "word": " فإذا", "probability": 0.83544921875}, {"start": 681.6, "end": 682.4, "word": " فيه", "probability": 0.706298828125}, {"start": 682.4, "end": 683.12, "word": " Transcription", "probability": 0.893798828125}, {"start": 683.12, "end": 683.94, "word": " factors", "probability": 0.66015625}, {"start": 683.94, "end": 684.8, "word": " إشي", "probability": 0.6813151041666666}, {"start": 684.8, "end": 685.36, "word": " بيخلي", "probability": 0.802001953125}, {"start": 685.36, "end": 686.28, "word": " certain", "probability": 0.55224609375}, {"start": 686.28, "end": 686.88, "word": " gene", "probability": 0.87255859375}, {"start": 686.88, "end": 687.64, "word": " become", "probability": 0.767578125}, {"start": 687.64, "end": 688.56, "word": " transcribed", "probability": 0.879638671875}], "temperature": 1.0}, {"id": 29, "seek": 70508, "start": 689.16, "end": 705.08, "text": "ممكن الـ Receptors for الـ Transcription Factors اللي هم الـ Main Group هم الـ Tyrosine Kinases الـ Tyrosine هو الـ Amino Acid والـ Kinase هو اللي بيحط الفسفات على الـ Tyrosine", "tokens": [2304, 43020, 2423, 39184, 1300, 1336, 830, 337, 2423, 39184, 6531, 12432, 33375, 830, 13672, 1829, 8032, 2304, 2423, 39184, 12383, 10500, 8032, 2304, 2423, 39184, 5569, 2635, 533, 27950, 1957, 2423, 39184, 5569, 2635, 533, 31439, 2423, 39184, 2012, 2982, 5097, 327, 16070, 39184, 27950, 651, 31439, 13672, 1829, 4724, 1829, 5016, 9566, 27188, 3794, 5172, 9307, 15844, 2423, 39184, 5569, 2635, 533], "avg_logprob": -0.33942307692307694, "compression_ratio": 1.5359477124183007, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 689.16, "end": 689.62, "word": "ممكن", "probability": 0.765380859375}, {"start": 689.62, "end": 689.8, "word": " الـ", "probability": 0.606201171875}, {"start": 689.8, "end": 690.62, "word": " Receptors", "probability": 0.6929728190104166}, {"start": 690.62, "end": 691.34, "word": " for", "probability": 0.274169921875}, {"start": 691.34, "end": 693.22, "word": " الـ", "probability": 0.5863037109375}, {"start": 693.22, "end": 694.02, "word": " Transcription", "probability": 0.8916015625}, {"start": 694.02, "end": 694.74, "word": " Factors", "probability": 0.867919921875}, {"start": 694.74, "end": 695.22, "word": " اللي", "probability": 0.7208251953125}, {"start": 695.22, "end": 695.4, "word": " هم", "probability": 0.605712890625}, {"start": 695.4, "end": 695.62, "word": " الـ", "probability": 0.7646484375}, {"start": 695.62, "end": 696.2, "word": " Main", "probability": 0.568359375}, {"start": 696.2, "end": 696.6, "word": " Group", "probability": 0.77392578125}, {"start": 696.6, "end": 696.9, "word": " هم", "probability": 0.496337890625}, {"start": 696.9, "end": 697.1, "word": " الـ", "probability": 0.61029052734375}, {"start": 697.1, "end": 697.58, "word": " Tyrosine", "probability": 0.84716796875}, {"start": 697.58, "end": 698.3, "word": " Kinases", "probability": 0.724853515625}, {"start": 698.3, "end": 699.0, "word": " الـ", "probability": 0.740234375}, {"start": 699.0, "end": 699.44, "word": " Tyrosine", "probability": 0.8359375}, {"start": 699.44, "end": 699.64, "word": " هو", "probability": 0.90869140625}, {"start": 699.64, "end": 699.78, "word": " الـ", "probability": 0.6754150390625}, {"start": 699.78, "end": 700.16, "word": " Amino", "probability": 0.880859375}, {"start": 700.16, "end": 700.58, "word": " Acid", "probability": 0.945068359375}, {"start": 700.58, "end": 700.82, "word": " والـ", "probability": 0.5546875}, {"start": 700.82, "end": 701.18, "word": " Kinase", "probability": 0.902587890625}, {"start": 701.18, "end": 701.3, "word": " هو", "probability": 0.9228515625}, {"start": 701.3, "end": 701.38, "word": " اللي", "probability": 0.96923828125}, {"start": 701.38, "end": 701.7, "word": " بيحط", "probability": 0.8759765625}, {"start": 701.7, "end": 702.3, "word": " الفسفات", "probability": 0.660888671875}, {"start": 702.3, "end": 703.16, "word": " على", "probability": 0.7822265625}, {"start": 703.16, "end": 703.88, "word": " الـ", "probability": 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"compression_ratio": 1.5368421052631578, "no_speech_prob": 1.7881393432617188e-07, "words": [{"start": 705.74, "end": 705.96, "word": "أو", "probability": 0.6767578125}, {"start": 705.96, "end": 706.2, "word": " بيقعوا", "probability": 0.5794189453125}, {"start": 706.2, "end": 706.58, "word": " بيشيلوا", "probability": 0.8810546875}, {"start": 706.58, "end": 706.76, "word": " منها", "probability": 0.977294921875}, {"start": 706.76, "end": 707.34, "word": " الفوسفات", "probability": 0.8243408203125}, {"start": 707.34, "end": 707.8, "word": " مرات", "probability": 0.88037109375}, {"start": 707.8, "end": 708.44, "word": " أخرى", "probability": 0.9921875}, {"start": 708.44, "end": 710.7, "word": " فـTyrosine", "probability": 0.5365651448567709}, {"start": 710.7, "end": 711.26, "word": " kinase", "probability": 0.759033203125}, {"start": 711.26, "end": 711.42, "word": " هم", "probability": 0.4854736328125}, {"start": 711.42, "end": 712.06, "word": " مجموعات", "probability": 0.6040283203125}, {"start": 712.06, "end": 713.34, "word": " من", "probability": 0.5498046875}, {"start": 713.34, "end": 713.44, "word": " طرابات", "probability": 0.40106201171875}, {"start": 713.44, "end": 715.68, "word": " إتصالية", "probability": 0.44173583984375}, {"start": 715.68, "end": 717.3, "word": " لعديد", "probability": 0.608001708984375}, {"start": 717.3, "end": 718.22, "word": " من", "probability": 0.96923828125}, {"start": 718.22, "end": 720.7, "word": " الهرمونات", "probability": 0.6801409040178571}, {"start": 720.7, "end": 720.94, "word": " أو", "probability": 0.9423828125}, {"start": 720.94, "end": 721.48, "word": " إتصالات", "probability": 0.88671875}, {"start": 721.48, "end": 721.8, "word": " من", "probability": 0.765625}, {"start": 721.8, "end": 722.28, "word": " خارج", "probability": 0.8751627604166666}, {"start": 722.28, "end": 722.74, "word": " الجسم", "probability": 0.35845947265625}, {"start": 722.74, "end": 725.24, "word": " لتصل", "probability": 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"word": " و", "probability": 0.61376953125}, {"start": 2512.95, "end": 2513.09, "word": " الـ", "probability": 0.5869140625}, {"start": 2513.09, "end": 2513.59, "word": " chromatin", "probability": 0.7568359375}, {"start": 2513.59, "end": 2514.55, "word": " modification", "probability": 0.818359375}, {"start": 2514.55, "end": 2514.95, "word": " الـ", "probability": 0.4205322265625}, {"start": 2514.95, "end": 2515.21, "word": " genes", "probability": 0.79296875}, {"start": 2515.21, "end": 2515.45, "word": " هذا", "probability": 0.8583984375}, {"start": 2515.45, "end": 2515.93, "word": " بالأول", "probability": 0.9720052083333334}], "temperature": 1.0}, {"id": 99, "seek": 253626, "start": 2516.62, "end": 2536.26, "text": "بس كل ما هذه الخلايا بتتكثروا بسرعة كتير السرعة بتخلي احتمالية الأخطاء تصير أكبر وهنا بتصير الأخطاء أكتر على مستوى الـChromosomes كلها مش بس Single Gene أو الـ Proto Oncogene الأول بس فبالتالي لما واحد يشوف", "tokens": [3555, 3794, 28242, 19446, 29538, 33962, 15040, 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السرطان هذا سيء وشرس وبيهاجم بسرعة وبينتشر بسرعة؟ فبيكون لأن الـ Control على الجينات سبعته سيء", "tokens": [6027, 39184, 26951, 26127, 50113, 1211, 14111, 995, 13672, 1829, 3714, 29245, 23328, 8978, 2423, 39184, 6377, 525, 26632, 4724, 3794, 3224, 12610, 3660, 4724, 1829, 15040, 38436, 805, 45, 12399, 1017, 45, 12399, 1649, 45, 295, 3632, 3532, 29160, 5229, 356, 2847, 23157, 4032, 1829, 30544, 23758, 10874, 11622, 38207, 9154, 2423, 39184, 41512, 735, 8477, 37495, 22653, 32239, 8592, 21136, 2288, 9566, 7649, 23758, 8608, 1829, 38207, 4032, 46309, 3794, 4032, 21292, 3224, 26108, 2304, 4724, 3794, 2288, 27884, 4032, 21292, 29399, 46309, 4724, 3794, 2288, 27884, 22807, 6156, 3555, 1829, 30544, 5296, 33456, 2423, 39184, 12912, 15844, 25724, 1829, 8315, 2655, 8608, 3555, 34268, 3224, 8608, 1829, 38207], "avg_logprob": -0.2018694266942995, "compression_ratio": 1.4621212121212122, "no_speech_prob": 1.7881393432617188e-05, "words": [{"start": 2536.41, "end": 2536.95, "word": "الـ", 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أو مستلزمة أو مستلزمة أو مستلزمة أو مستلزمة أو مستلزمة أو مستلزمة أو مستلزمة أو مستلزمة أو مستلزمة أو مستلزمة أو مستلزمة أو مستلزمة أو مستلزمة أو مستلزمة أو مستلزمة أو مستلزمة أو مست", "tokens": [5172, 995, 286, 519, 341, 37495, 22653, 4137, 34051, 37495, 22653, 27188, 4117, 25720, 6055, 3555, 34268, 3224, 36145, 3224, 10060, 295, 2035, 5592, 8660, 264, 5592, 11843, 43729, 345, 984, 34051, 2609, 34051, 8717, 31371, 7435, 3660, 9154, 3714, 1829, 2407, 38251, 9307, 1829, 4117, 10632, 34051, 3714, 14851, 1211, 11622, 46007, 34051, 3714, 14851, 1211, 11622, 46007, 34051, 3714, 14851, 1211, 11622, 46007, 34051, 3714, 14851, 1211, 11622, 46007, 34051, 3714, 14851, 1211, 11622, 46007, 34051, 3714, 14851, 1211, 11622, 46007, 34051, 3714, 14851, 1211, 11622, 46007, 34051, 3714, 14851, 1211, 11622, 46007, 34051, 3714, 14851, 1211, 11622, 46007, 34051, 3714, 14851, 1211, 11622, 46007, 34051, 3714, 14851, 1211, 11622, 46007, 34051, 3714, 14851, 1211, 11622, 46007, 34051, 3714, 14851, 1211, 11622, 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4024.58, "word": " VCR", "probability": 0.6661376953125}, {"start": 4024.58, "end": 4025.02, "word": " على", "probability": 0.73486328125}, {"start": 4025.02, "end": 4025.4, "word": " الـ", "probability": 0.946044921875}, {"start": 4025.4, "end": 4026.36, "word": " AVL1", "probability": 0.8450520833333334}, {"start": 4026.36, "end": 4028.42, "word": " فالـ", "probability": 0.93212890625}, {"start": 4028.42, "end": 4029.04, "word": " VCR", "probability": 0.85400390625}, {"start": 4029.04, "end": 4030.16, "word": " AVL1", "probability": 0.97021484375}, {"start": 4030.16, "end": 4030.72, "word": " هو", "probability": 0.97900390625}, {"start": 4030.72, "end": 4032.5, "word": " البروتين", "probability": 0.610382080078125}, {"start": 4032.5, "end": 4033.18, "word": " الجديد", "probability": 0.8483072916666666}, {"start": 4033.18, "end": 4033.9, "word": " الـ", "probability": 0.696533203125}, {"start": 4033.9, "end": 4034.2, "word": " Product", "probability": 0.59716796875}, {"start": 4034.2, "end": 4034.94, "word": " تبعه", "probability": 0.9344482421875}, {"start": 4034.94, "end": 4036.1, "word": " ولأنه", "probability": 0.8020833333333334}, {"start": 4036.1, "end": 4036.58, "word": " دخل", "probability": 0.7803548177083334}, {"start": 4036.58, "end": 4036.82, "word": " بالـ", "probability": 0.871826171875}, {"start": 4036.82, "end": 4037.32, "word": " VCR", "probability": 0.795654296875}, {"start": 4037.32, "end": 4038.06, "word": " يعني", "probability": 0.80126953125}, {"start": 4038.06, "end": 4038.46, "word": " بالـ", "probability": 0.737060546875}, {"start": 4038.46, "end": 4038.7, "word": " B", "probability": 0.63427734375}, {"start": 4038.7, "end": 4038.98, "word": " Cell", "probability": 0.289794921875}, {"start": 4038.98, "end": 4039.78, "word": " Surface", "probability": 0.7021484375}, {"start": 4039.78, "end": 4040.92, "word": " Receptor", "probability": 0.9267578125}, {"start": 4040.92, "end": 4041.64, "word": " بيخلّي", "probability": 0.7975667317708334}, {"start": 4041.64, "end": 4041.9, "word": " أنه", "probability": 0.769775390625}, {"start": 4041.9, "end": 4042.5, "word": " بيخرّب", "probability": 0.90849609375}], "temperature": 1.0}, {"id": 155, "seek": 406572, "start": 4044.22, "end": 4065.72, "text": "الخلايا الدم بحيث إنه بيكون نوع من السلطنات محدد أو بشكل معين، اسمه الـCML ويكون عندي Translocation بين أدولة الـTwo Points والنتيجة إن الـABL1 جين والبروتين تبعه يصير يشبك مع الـPCR", "tokens": [6027, 9778, 15040, 25528, 32748, 2304, 4724, 5016, 1829, 12984, 36145, 3224, 4724, 1829, 30544, 8717, 45367, 9154, 21136, 1211, 9566, 8315, 2655, 3714, 24401, 3215, 34051, 4724, 8592, 28820, 20449, 9957, 12399, 24525, 2304, 3224, 2423, 39184, 34, 12683, 4032, 1829, 30544, 18871, 16254, 6531, 5842, 399, 49374, 5551, 3215, 12610, 3660, 2423, 39184, 33594, 44763, 16070, 29399, 1829, 7435, 3660, 36145, 2423, 39184, 13868, 43, 16, 10874, 9957, 16070, 26890, 35473, 9957, 6055, 3555, 3615, 3224, 7251, 9381, 13546, 7251, 8592, 3555, 4117, 20449, 2423, 39184, 12986, 49], "avg_logprob": -0.17256181809928392, "compression_ratio": 1.4660194174757282, "no_speech_prob": 1.4007091522216797e-05, "words": [{"start": 4044.2200000000003, "end": 4045.3, "word": "الخلايا", "probability": 0.8878173828125}, {"start": 4045.3, "end": 4045.8, "word": " الدم", "probability": 0.915771484375}, {"start": 4045.8, "end": 4046.2, "word": " بحيث", "probability": 0.8572998046875}, {"start": 4046.2, "end": 4046.62, "word": " إنه", "probability": 0.76416015625}, {"start": 4046.62, "end": 4047.16, "word": " بيكون", "probability": 0.86767578125}, {"start": 4047.16, "end": 4047.48, "word": " نوع", "probability": 0.97900390625}, {"start": 4047.48, "end": 4047.68, "word": " من", "probability": 0.96728515625}, {"start": 4047.68, "end": 4048.48, "word": " السلطنات", "probability": 0.74462890625}, {"start": 4048.48, "end": 4049.14, "word": " محدد", "probability": 0.9471028645833334}, {"start": 4049.14, "end": 4049.78, "word": " أو", "probability": 0.97705078125}, 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malignancies أحنا هاي البركة الليمبومة acute lymphoplastic leukemia acute lymphoplasty اللي فيه more than for acute lymphoplastic acute promyelocytic اللي قابلني ALL7A3 لـpromyelocytic أو chronic lymphocytic leukemia", "tokens": [2407, 41185, 43242, 11296, 29538, 2423, 33599, 1829, 16606, 37037, 24192, 9122, 2304, 7649, 3714, 15040, 5016, 19913, 3660, 8978, 9122, 2655, 13546, 9154, 2423, 39184, 8636, 267, 36661, 2806, 788, 32286, 5551, 5016, 8315, 8032, 47302, 2423, 26890, 4117, 3660, 13672, 32640, 3555, 20498, 3660, 24390, 31070, 33224, 2750, 45970, 29958, 24390, 31070, 33224, 9820, 13672, 1829, 8978, 3224, 544, 813, 337, 24390, 31070, 33224, 2750, 24390, 2234, 88, 338, 905, 43658, 13672, 1829, 12174, 16758, 1211, 22653, 14824, 22, 32, 18, 5296, 39184, 28722, 88, 338, 905, 43658, 34051, 14493, 31070, 905, 43658, 45970, 29958], "avg_logprob": -0.35395409166812897, "compression_ratio": 1.6069868995633187, "no_speech_prob": 1.0132789611816406e-06, "words": [{"start": 4096.56, "end": 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هذه الخلايا تبع هذه المجموعة وهذه المجموعة طريقة القراءة، فانت هنا الجهاز هذا، الدراسة هذه في هذه الـStudies Specifically درسوا عن حوالي 100 جيون", "tokens": [10721, 2407, 3714, 14851, 2407, 7578, 2423, 26890, 35473, 9957, 9122, 3215, 3224, 16472, 16254, 4724, 32887, 2655, 9957, 8717, 9307, 7435, 8978, 29538, 33962, 15040, 25528, 6055, 3555, 3615, 29538, 9673, 7435, 2304, 2407, 27884, 4032, 3224, 24192, 9673, 7435, 2304, 2407, 27884, 23032, 16572, 28671, 25062, 2288, 16606, 3660, 12399, 6156, 7649, 2655, 34105, 25724, 3224, 31377, 23758, 12399, 32748, 23557, 3794, 3660, 29538, 8978, 29538, 2423, 39184, 42665, 530, 26058, 11778, 2288, 3794, 14407, 18871, 11331, 2407, 6027, 1829, 2319, 10874, 1829, 11536], "avg_logprob": -0.19881465791285724, "compression_ratio": 1.6294416243654823, "no_speech_prob": 2.7894973754882812e-05, "words": [{"start": 4433.89, "end": 4434.31, "word": "أو", "probability": 0.979736328125}, {"start": 4434.31, "end": 4435.25, "word": " مستوى", "probability": 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"word": " أحمر", "probability": 0.8605143229166666}, {"start": 4533.61, "end": 4534.41, "word": " بالأول", "probability": 0.9205729166666666}, {"start": 4534.41, "end": 4535.55, "word": " معناته", "probability": 0.9873046875}, {"start": 4535.55, "end": 4536.35, "word": " إنه", "probability": 0.597412109375}, {"start": 4536.35, "end": 4536.91, "word": " هذا", "probability": 0.951171875}, {"start": 4536.91, "end": 4537.37, "word": " الـ", "probability": 0.7529296875}, {"start": 4537.37, "end": 4537.79, "word": " expression", "probability": 0.92724609375}, {"start": 4537.79, "end": 4538.25, "word": " تبعه", "probability": 0.977783203125}, {"start": 4538.25, "end": 4539.13, "word": " قلب", "probability": 0.683837890625}, {"start": 4539.13, "end": 4539.85, "word": " بطل", "probability": 0.83984375}, {"start": 4539.85, "end": 4540.13, "word": " يكون", "probability": 0.98681640625}, {"start": 4540.13, "end": 4540.55, "word": " منه", "probability": 0.981201171875}, {"start": 4540.55, "end": 4542.29, "word": " وبالنسبة", "probability": 0.89921875}, {"start": 4542.29, "end": 4544.13, "word": " لأخضر", "probability": 0.91162109375}, {"start": 4544.13, "end": 4545.03, "word": " معناته", "probability": 0.9601236979166666}, {"start": 4545.03, "end": 4545.39, "word": " الـ", "probability": 0.8603515625}, {"start": 4545.39, "end": 4545.79, "word": " expression", "probability": 0.849609375}, {"start": 4545.79, "end": 4546.33, "word": " level", "probability": 0.5546875}, {"start": 4546.33, "end": 4546.87, "word": " أكبر", "probability": 0.94482421875}, {"start": 4546.87, "end": 4547.71, "word": " فهنا", "probability": 0.8466796875}, {"start": 4547.71, "end": 4547.91, "word": " زي", "probability": 0.980224609375}, {"start": 4547.91, "end": 4548.03, "word": " ما", "probability": 0.95361328125}, {"start": 4548.03, "end": 4548.13, "word": " هم", "probability": 0.69482421875}, {"start": 4548.13, "end": 4548.73, "word": " حاطينك", "probability": 0.9512939453125}, {"start": 4548.73, 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{"start": 4604.75, "end": 4605.51, "word": " بالأخير", "probability": 0.87158203125}, {"start": 4605.51, "end": 4606.53, "word": " بهمني", "probability": 0.79248046875}, {"start": 4606.53, "end": 4606.81, "word": " شو", "probability": 0.916015625}, {"start": 4606.81, "end": 4607.61, "word": " المجموعة", "probability": 0.85615234375}, {"start": 4607.61, "end": 4608.43, "word": " اللي", "probability": 0.87060546875}, {"start": 4608.43, "end": 4609.61, "word": " مجموعة", "probability": 0.826806640625}, {"start": 4609.61, "end": 4610.53, "word": " الجينات", "probability": 0.906494140625}, {"start": 4610.53, "end": 4611.37, "word": " اللي", "probability": 0.990478515625}, {"start": 4611.37, "end": 4614.05, "word": " يعني", "probability": 0.900146484375}, {"start": 4614.05, "end": 4615.51, "word": " صار", "probability": 0.958251953125}, {"start": 4615.51, "end": 4615.77, "word": " لها", "probability": 0.5928955078125}, {"start": 4615.77, "end": 4616.07, "word": " over", "probability": 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" hypothetical", "probability": 0.95947265625}, {"start": 4624.43, "end": 4625.65, "word": " افتراضي", "probability": 0.7925618489583334}], "temperature": 1.0}, {"id": 176, "seek": 465587, "start": 4626.23, "end": 4655.87, "text": "إنه أنا بس جيت درست الموضوع هذا كان عندي مثلا tumor A من المجموعة الـ Individual اللي عندهم كان tumor A و tumor B وقارنت بينهم أو ممكن حطوا طبعاً بالأول بيكونوا حاطين الـ Background أو الأصل اللي هو الـ Normal فأنا راح ألاقي إنه المجموعة هذه certain genes هذه بالزاوية هذه بيكون much higher in A than in B", "tokens": [28814, 1863, 3224, 41850, 4724, 3794, 10874, 36081, 11778, 2288, 14851, 9673, 2407, 11242, 45367, 23758, 25961, 18871, 16254, 50113, 15040, 22512, 316, 9154, 9673, 7435, 2304, 2407, 27884, 2423, 39184, 37292, 13672, 1829, 43242, 16095, 25961, 22512, 316, 4032, 22512, 363, 4032, 4587, 9640, 1863, 2655, 49374, 16095, 34051, 3714, 43020, 11331, 9566, 14407, 23032, 3555, 3615, 995, 14111, 20666, 10721, 12610, 4724, 1829, 30544, 14407, 11331, 41193, 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راح", "probability": 0.99169921875}, {"start": 4645.05, "end": 4645.49, "word": " ألاقي", "probability": 0.97509765625}, {"start": 4645.49, "end": 4646.71, "word": " إنه", "probability": 0.798095703125}, {"start": 4646.71, "end": 4648.89, "word": " المجموعة", "probability": 0.86572265625}, {"start": 4648.89, "end": 4649.19, "word": " هذه", "probability": 0.8486328125}, {"start": 4649.19, "end": 4649.63, "word": " certain", "probability": 0.23193359375}, {"start": 4649.63, "end": 4650.07, "word": " genes", "probability": 0.95654296875}, {"start": 4650.07, "end": 4650.33, "word": " هذه", "probability": 0.677734375}, {"start": 4650.33, "end": 4651.07, "word": " بالزاوية", "probability": 0.880859375}, {"start": 4651.07, "end": 4651.51, "word": " هذه", "probability": 0.943359375}, {"start": 4651.51, "end": 4652.53, "word": " بيكون", "probability": 0.76953125}, {"start": 4652.53, "end": 4653.43, "word": " much", "probability": 0.7958984375}, {"start": 4653.43, "end": 4653.93, "word": " higher", "probability": 0.92529296875}, {"start": 4653.93, "end": 4654.37, "word": " in", "probability": 0.94970703125}, {"start": 4654.37, "end": 4654.75, "word": " A", "probability": 0.95556640625}, {"start": 4654.75, "end": 4655.35, "word": " than", "probability": 0.95849609375}, {"start": 4655.35, "end": 4655.63, "word": " in", "probability": 0.94140625}, {"start": 4655.63, "end": 4655.87, "word": " B", "probability": 0.9951171875}], "temperature": 1.0}, {"id": 177, "seek": 468575, "start": 4656.99, "end": 4685.75, "text": "ويعني هنا دول المجموعة الـA الـExpression تبعهم أخضر لهذه الجينات جين 1، جين 25 و27 بحدد أي جينات اللي هنا وهنا أقل مجموعة بالنسبة للـTumor B أقل من إتريا هنا بتصير قل وبعدين هنا مجموعة الجينات هذه شغالة أكتر كثير عند اللي عندهم Type B tumor", "tokens": [2407, 40228, 22653, 34105, 11778, 12610, 9673, 7435, 2304, 2407, 27884, 2423, 39184, 32, 2423, 39184, 11149, 79, 2775, 6055, 3555, 3615, 16095, 5551, 9778, 11242, 2288, 46740, 24192, 25724, 1829, 8315, 2655, 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"text": "أقدر أقارن بينهم سواء الـ «تجارب مختلفة» «تجارب مختلفة» «تجارب مختلفة» «تجارب مختلفة» «تجارب مختلفة» «تجارب مختلفة» «تجارب مختلفة» «تجارب مختلفة» «تجارب مختلفة» «تجارب مختلفة» «تجارب مختلفة» «تجارب مختلفة» «تجارب مختلفة» «تجارب مختلفة» «تجارب مختلفة» «تجارب مختلفة» «تجارب مختلفة» «تجارب مختلفة» «تجارب مختلفة» «تجارب مختلفة» «تجارب مختلفة»", "tokens": [10721, 28543, 2288, 5551, 4587, 9640, 1863, 49374, 16095, 8608, 2407, 16606, 2423, 39184, 4657, 2655, 7435, 9640, 3555, 3714, 46456, 46538, 3660, 5933, 4657, 2655, 7435, 9640, 3555, 3714, 46456, 46538, 3660, 5933, 4657, 2655, 7435, 9640, 3555, 3714, 46456, 46538, 3660, 5933, 4657, 2655, 7435, 9640, 3555, 3714, 46456, 46538, 3660, 5933, 4657, 2655, 7435, 9640, 3555, 3714, 46456, 46538, 3660, 5933, 4657, 2655, 7435, 9640, 3555, 3714, 46456, 46538, 3660, 5933, 4657, 2655, 7435, 9640, 3555, 3714, 46456, 46538, 3660, 5933, 4657, 2655, 7435, 9640, 3555, 3714, 46456, 46538, 3660, 5933, 4657, 2655, 7435, 9640, 3555, 3714, 46456, 46538, 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بالباقية معناته لأ ما كان إله دخله ما إله كان إله دور يعني هاي الأشياء بتكون بأذا الشكل هنا بنفس الطريقة يعني هاي على نفس المبدأ اللي شفناها قبل شوية", "tokens": [2407, 6027, 20292, 50113, 1211, 14111, 995, 28242, 3224, 5551, 9381, 5172, 2288, 20666, 3555, 995, 4587, 10632, 20449, 8315, 47395, 5296, 10721, 19446, 25961, 11933, 43761, 11778, 9778, 1211, 3224, 19446, 11933, 43761, 25961, 11933, 43761, 11778, 13063, 37495, 22653, 8032, 47302, 16247, 8592, 1829, 16606, 39894, 30544, 4724, 10721, 15730, 25124, 28820, 34105, 44945, 36178, 41950, 16572, 28671, 37495, 22653, 8032, 47302, 15844, 8717, 36178, 9673, 44510, 10721, 13672, 1829, 13412, 5172, 8315, 11296, 12174, 36150, 13412, 2407, 10632], "avg_logprob": -0.2016006110281479, "compression_ratio": 1.8493975903614457, "no_speech_prob": 1.7881393432617188e-07, "words": [{"start": 4738.62, "end": 4739.14, "word": "واللي", "probability": 0.8738606770833334}, {"start": 4739.14, "end": 4739.56, "word": " مثلًا", "probability": 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{"start": 4796.87, "end": 4797.39, "word": " حتى", "probability": 0.936767578125}, {"start": 4797.39, "end": 4798.25, "word": " يثبتوا", "probability": 0.96796875}, {"start": 4798.25, "end": 4799.05, "word": " إنه", "probability": 0.84716796875}, {"start": 4799.05, "end": 4799.89, "word": " والله", "probability": 0.95166015625}, {"start": 4799.89, "end": 4800.37, "word": " الجين", "probability": 0.76318359375}, {"start": 4800.37, "end": 4801.77, "word": " الإفلاني", "probability": 0.75498046875}, {"start": 4801.77, "end": 4802.87, "word": " هو", "probability": 0.93359375}, {"start": 4802.87, "end": 4804.17, "word": " المهم", "probability": 0.882568359375}, {"start": 4804.17, "end": 4804.79, "word": " وهو", "probability": 0.68359375}, {"start": 4804.79, "end": 4805.37, "word": " اللي", "probability": 0.9599609375}, {"start": 4805.37, "end": 4806.49, "word": " يعني", "probability": 0.803955078125}, {"start": 4806.49, "end": 4809.69, "word": " اللي", "probability": 0.919677734375}, {"start": 4809.69, "end": 4810.25, "word": " له", "probability": 0.1639404296875}, {"start": 4810.25, "end": 4810.57, "word": " دور", "probability": 0.9921875}, {"start": 4810.57, "end": 4811.11, "word": " أكبر", "probability": 0.9806315104166666}, {"start": 4811.11, "end": 4812.35, "word": " أحيانًا", "probability": 0.932861328125}, {"start": 4812.35, "end": 4813.01, "word": " من", "probability": 0.96826171875}, {"start": 4813.01, "end": 4814.99, "word": " يعني", "probability": 0.775634765625}, {"start": 4814.99, "end": 4815.77, "word": " طريقة", "probability": 0.9923502604166666}, {"start": 4815.77, "end": 4817.77, "word": " المتابعة", "probability": 0.928955078125}, {"start": 4817.77, "end": 4818.89, "word": " للمرضى", "probability": 0.9078369140625}], "temperature": 1.0}, {"id": 183, "seek": 484482, "start": 4821.46, "end": 4844.82, "text": "إنه أنا أربط الموضوع هذا بالنسبة للـGene Expression مع الـSurvivor يعني أنا عندي الآن مثلا ميت مريض lung cancer نفترض هيك وأخدت بالـDiagnosis lung cancer وجيت بعدين عملت نوع من الدراسة زي هذه", "tokens": [28814, 1863, 3224, 41850, 5551, 25513, 9566, 9673, 2407, 11242, 45367, 23758, 20666, 1863, 35457, 3660, 24976, 39184, 38, 1450, 21391, 2775, 20449, 2423, 39184, 36616, 27810, 284, 37495, 22653, 41850, 18871, 16254, 6024, 48506, 50113, 15040, 3714, 36081, 3714, 16572, 11242, 16730, 5592, 8717, 5172, 2655, 43042, 39896, 4117, 36725, 9778, 3215, 2655, 20666, 39184, 35, 72, 4535, 8211, 16730, 5592, 49610, 36081, 39182, 9957, 6225, 42213, 2655, 8717, 45367, 9154, 32748, 23557, 3794, 3660, 30767, 1829, 29538], "avg_logprob": -0.16982422526925803, "compression_ratio": 1.4444444444444444, "no_speech_prob": 2.205371856689453e-06, "words": [{"start": 4821.46, "end": 4822.32, "word": "إنه", "probability": 0.7775065104166666}, {"start": 4822.32, "end": 4822.52, "word": " أنا", "probability": 0.796875}, {"start": 4822.52, "end": 4823.06, "word": " أربط", "probability": 0.9723307291666666}, {"start": 4823.06, "end": 4823.58, "word": " 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"word": " ميت", "probability": 0.833740234375}, {"start": 4832.54, "end": 4832.94, "word": " مريض", "probability": 0.9895833333333334}, {"start": 4832.94, "end": 4833.16, "word": " lung", "probability": 0.5283203125}, {"start": 4833.16, "end": 4833.84, "word": " cancer", "probability": 0.9658203125}, {"start": 4833.84, "end": 4835.2, "word": " نفترض", "probability": 0.9288330078125}, {"start": 4835.2, "end": 4835.56, "word": " هيك", "probability": 0.826171875}, {"start": 4835.56, "end": 4837.42, "word": " وأخدت", "probability": 0.7958984375}, {"start": 4837.42, "end": 4838.72, "word": " بالـDiagnosis", "probability": 0.8483072916666666}, {"start": 4838.72, "end": 4839.06, "word": " lung", "probability": 0.55712890625}, {"start": 4839.06, "end": 4839.86, "word": " cancer", "probability": 0.9306640625}, {"start": 4839.86, "end": 4841.24, "word": " وجيت", "probability": 0.85400390625}, {"start": 4841.24, "end": 4842.66, "word": " بعدين", "probability": 0.7392578125}, {"start": 4842.66, 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0.689361572265625}, {"start": 5281.39, "end": 5281.61, "word": " الله", "probability": 0.4921875}, {"start": 5281.61, "end": 5282.03, "word": " يكرمك", "probability": 0.916259765625}, {"start": 5282.03, "end": 5282.29, "word": " سلام", "probability": 0.5211181640625}, {"start": 5282.29, "end": 5282.93, "word": " عليك", "probability": 0.933837890625}, {"start": 5282.93, "end": 5283.73, "word": " برعاية", "probability": 0.8044921875}, {"start": 5283.73, "end": 5283.95, "word": " الله", "probability": 0.96240234375}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 5287.206875, "duration_after_vad": 5171.885343750018}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/K4hCcRDLuUY_postprocess.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/K4hCcRDLuUY_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..25b3c5c84ff884645e818984da47ef65ef07ac85
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/K4hCcRDLuUY_postprocess.srt
@@ -0,0 +1,3956 @@
+1
+00:00:00,000 --> 00:00:08,880
+بحب إنه الواحد مننا يكون بهنه صورة كاملة وهيك
+
+2
+00:00:08,880 --> 00:00:13,120
+يحاول يفهم إحنا بنحاول شو نقول أو شو ندرس أو شو
+
+3
+00:00:13,120 --> 00:00:16,980
+نتعامل الآن
+
+4
+00:00:16,980 --> 00:00:23,480
+الوراثة بتعتمد على إن الـDNA اللي اتكلمنا عنه اللي
+
+5
+00:00:23,480 --> 00:00:29,450
+هو أساس في تكون البروتينوهو المسئول عن تكوين
+
+6
+00:00:29,450 --> 00:00:38,290
+البروتينات وهو موجود بشكل متساوي في الغالب يعني كل
+
+7
+00:00:38,290 --> 00:00:45,230
+الخلايا، ما عدا الخلايا الجنسية ويكون الخلايا
+
+8
+00:00:45,230 --> 00:00:52,350
+بتقوم بطريقة دقيقة جداً بعملية تكرار الـDNA حيث
+
+9
+00:00:52,350 --> 00:00:57,670
+إنه دايماًالـ «DNA» تبع كل الخلايا الأصلي يقول
+
+10
+00:00:57,670 --> 00:01:07,450
+«كله متشابه» بعدين يعني اتكلمنا عن إنه عندنا يعني
+
+11
+00:01:07,450 --> 00:01:12,390
+هيك كمبدأ بدي الواحد هيك يتذكر وبعدين قضية إنه
+
+12
+00:01:12,390 --> 00:01:18,290
+احنا تقريباً كأنواع مراد وحلال بتمني في الوراثة
+
+13
+00:01:18,290 --> 00:01:24,990
+نتكلم على ثلاث أنواعفي حالات أو أمراض نتيجة تخلني
+
+14
+00:01:24,990 --> 00:01:29,090
+في الكروموزوم كله فالـ Chromosomal Diseases هدول
+
+15
+00:01:29,090 --> 00:01:33,370
+عادة اكبار كثير واللي هم مشاكل كثيرة زي الـ Down
+
+16
+00:01:33,370 --> 00:01:39,910
+Syndrome وفي Mendelian Diseases اللي هي بيقول فقط
+
+17
+00:01:39,910 --> 00:01:44,890
+Single Gene هو المسؤول عن المرض وفي علاقة بينهم
+
+18
+00:01:44,890 --> 00:01:49,910
+وفي لها أمثلةوالشغل الثالث اللي هي الغالبين أغمض
+
+19
+00:01:49,910 --> 00:01:53,170
+من كثير من الأمراض زي الضغط والسكري والربو
+
+20
+00:01:53,170 --> 00:02:00,050
+والأمراض الكثيرة في حالات بيكون أنه بيشترك عدد
+
+21
+00:02:00,050 --> 00:02:04,430
+كبير من الجينات فيها بس مش chromosome عدد كبير من
+
+22
+00:02:04,430 --> 00:02:14,470
+الجينات النوع الثالث هذا مرتبط بقالية التحكم في
+
+23
+00:02:14,470 --> 00:02:21,680
+الـExpression للـGeneيعني بدك تفهم إنك أنت الجين
+
+24
+00:02:21,680 --> 00:02:26,920
+الواحد مش شغال في كل الخلايا الخلية اللي بتحتاج
+
+25
+00:02:26,920 --> 00:02:32,120
+هذا الجين يشتغل هي الخلية اللي راح تشغله وأحيانًا
+
+26
+00:02:32,120 --> 00:02:41,210
+كثيرة يعني من الـ22، 23 ألف جين موجودينبكون عدد
+
+27
+00:02:41,210 --> 00:02:46,310
+قليل من الجينات اللي… يعني نسبة قليلة من الجينات
+
+28
+00:02:46,310 --> 00:02:53,570
+بتتم تشغيلها، ف… آليات التحكم في مين من الجينات
+
+29
+00:02:53,570 --> 00:02:57,950
+يشتغل ومين ما يشتغلش وإمتى يشتغل وإمتى ما يشتغلش،
+
+30
+00:02:57,950 --> 00:03:01,910
+هذه بدنا نسميها Epigenetic Mechanisms، اللي هي
+
+31
+00:03:01,910 --> 00:03:09,740
+آليات التحكم في التنشيط أو تنويم الجيناتوالفروقات
+
+32
+00:03:09,740 --> 00:03:15,320
+فيها فهذه الظواهر اللي بنتكلم عنها كـ Epigenetic
+
+33
+00:03:15,320 --> 00:03:22,800
+عملية التخلق كيف بتتم عمليات متعددة وكثيرة وهي
+
+34
+00:03:22,800 --> 00:03:27,300
+يعني يعني
+
+35
+00:03:27,300 --> 00:03:33,520
+هي بتقوم الآن يعني بيحاولوا أنه من خلالها يعني
+
+36
+00:03:33,520 --> 00:03:39,620
+يفهموا كثير من الأمراض، بعض الأمراضوبيلاحظوا إنه
+
+37
+00:03:39,620 --> 00:03:45,920
+ممكن نفهم منها أو من خلالها أيضًا للآن ما نجحوش بس
+
+38
+00:03:45,920 --> 00:03:53,480
+بتأملوا إنه يكونوا أدوي أو طرائق تعديل المرض من
+
+39
+00:03:53,480 --> 00:04:00,560
+خلال التدخل بطريقة مفيدة أو ضد المرض في إنه شو
+
+40
+00:04:00,560 --> 00:04:04,830
+اللي بدنا يعيش تشتغل وشو اللي بدنا يعيش مشتغلشالآن
+
+41
+00:04:04,830 --> 00:04:11,050
+المحاضرة الفاصلة الثالث هي بتتكلم عن تركيب
+
+42
+00:04:11,050 --> 00:04:17,690
+الكرموزومات والجينات وكيف هي موجودة على الـDNA في
+
+43
+00:04:17,690 --> 00:04:24,170
+وسط الخلية المحاضرة اللي بعدها، الثانية، راح نتكلم
+
+44
+00:04:24,170 --> 00:04:29,430
+كيف إحنا متنوعين، شو الاختلافات اللي موجودة بين
+
+45
+00:04:29,430 --> 00:04:38,020
+البشر عموما، وبالتالي يعني محاولة تشرحالوجود تفاوت
+
+46
+00:04:38,020 --> 00:04:44,460
+بين البشر إنه مش بس التفاوت هو نتيجة اختلاف الـ
+
+47
+00:04:44,460 --> 00:04:49,620
+DNA نفسه على مستوى الجينات نفسها الـ Epigenetic
+
+48
+00:04:49,620 --> 00:04:54,260
+Mechanisms دولة كمان اللي لهم دور في إنه هذا
+
+49
+00:04:54,260 --> 00:04:59,000
+الإنسان يطلع شويه مختلف عن الإنسانفهنا مثلًا مثال
+
+50
+00:04:59,000 --> 00:05:04,480
+إنه أنا الـ… بالـKaryotype طبعًا إذا حد مش فاهم
+
+51
+00:05:04,480 --> 00:05:11,340
+إيش يوقف يعني دكتور أحمد أطلب من أي إنسان عنده أنا
+
+52
+00:05:11,340 --> 00:05:16,200
+مش حاطط الـChat أو مش مبين معاه الـChat إذا بدكم
+
+53
+00:05:16,200 --> 00:05:21,180
+أحطه Show Video Grid ولا كده إذا حد بيحب يسأل أو
+
+54
+00:05:21,180 --> 00:05:26,590
+على الـFacebook أو الـWhatsApp بيسأل سؤالبرضه
+
+55
+00:05:26,590 --> 00:05:30,850
+بيصير فإذا
+
+56
+00:05:30,850 --> 00:05:38,130
+أخدنا الآن يعني لما إحنا نيجي نقرأ الـ بدقة أكثر
+
+57
+00:05:38,130 --> 00:05:44,550
+تركيب الـ Gene وتركيب الـ DNA أو الـ Chromosome
+
+58
+00:05:44,550 --> 00:05:50,530
+اللي هو الكتلة الكبيرة بلاقي إن أنا لما أجي أشوف
+
+59
+00:05:50,530 --> 00:05:55,630
+Chromosome زي هنا Chromosome 11كنا نحكي إنه فيه
+
+60
+00:05:55,630 --> 00:06:00,470
+Centromere بالنصر عشان يعرف يتوجه للجهتين
+
+61
+00:06:00,470 --> 00:06:05,010
+المتضادات في انقسام الخلية في إشي زي الـTelomere
+
+62
+00:06:05,010 --> 00:06:09,810
+عشان اللي هو الإشي المطرف اللي آخرته مسبحة عشان
+
+63
+00:06:09,810 --> 00:06:16,570
+يتحكم في عدد مرات انقسام الخلايا فإذا بناخد إنه
+
+64
+00:06:16,570 --> 00:06:22,050
+أنا جبت في لحظة معينة اللي هو الـChromosome 11
+
+65
+00:06:23,210 --> 00:06:28,890
+المنطقة اللي هي الخامس
+
+66
+00:06:28,890 --> 00:06:34,070
+وفاصل الخمستاشر إلى الخامس وفاصل الخمس وثلاثين
+
+67
+00:06:34,070 --> 00:06:40,070
+يعني هنا هاي القطعة الصغيرة اللي بيسموها الـP اللي
+
+68
+00:06:40,070 --> 00:06:46,270
+هي P للتحت وبعدين الـQ الطويل للتحت عادةً بنبدأ من
+
+69
+00:06:46,270 --> 00:06:52,780
+فوق ونمشي فيهم للتحتفبنلاحظ إنه في مناطق فيها كثير
+
+70
+00:06:52,780 --> 00:06:58,760
+جينات وفيها طريقة إن الواحد يعرف إن هذا عبارة عن
+
+71
+00:06:58,760 --> 00:07:07,420
+جين يعني قطعة الـ DNA يتم قراءتها يقدر زي ما حكيت
+
+72
+00:07:07,420 --> 00:07:12,700
+المرة اللي فاتت إنه حوالي 4% فقط من الـ DNA في
+
+73
+00:07:12,700 --> 00:07:19,900
+الإنسان عبارة عن coding DNA يعنيإبارة عن إشي راح
+
+74
+00:07:19,900 --> 00:07:25,160
+يتم استفادة منه في عمل البروتين لاحقًا والغالبية
+
+75
+00:07:25,160 --> 00:07:30,480
+العظمى من الـDNA إبارة عن الـNon-Coding DNA يعني
+
+76
+00:07:30,480 --> 00:07:38,620
+بس تكمالة وحشوة وإشي موجود بالنصيعني يظن إن هذا
+
+77
+00:07:38,620 --> 00:07:43,100
+بيساعد لأنه حتى لو صار خلل في الـ DNA إنه يصير
+
+78
+00:07:43,100 --> 00:07:48,300
+احتمالية أكبر إن يكون الخلل في منطقة غير ضارة أو
+
+79
+00:07:48,300 --> 00:07:54,680
+غير مسببة لمرض يعني هيك يظن الآن فلو جينا ناخد هذه
+
+80
+00:07:54,680 --> 00:07:58,300
+القطعة الصغيرة اللي هي موجودة هنا بالـ Karyotype
+
+81
+00:07:58,300 --> 00:08:03,900
+بشكل الـ Karyotype لـ Chromosome 11 وأنا أكبرها
+
+82
+00:08:03,900 --> 00:08:09,140
+أكترفإذا دخلت بتفاصيل أكثر، وحلاقي إنه في حوالي
+
+83
+00:08:09,140 --> 00:08:12,780
+هنا بعد وظنني قالوا عشر جينات موجودات في هذا
+
+84
+00:08:12,780 --> 00:08:19,520
+المكان وفي الغالب بنلاحظ إنه في تقارب في وظائف هذه
+
+85
+00:08:19,520 --> 00:08:25,120
+الجيناتففي الغالب هنا بتتكلموا على إشي اسمه الـ
+
+86
+00:08:25,120 --> 00:08:29,620
+Olfactory Receptor Genes وهدولة خمسة بجانب بعض
+
+87
+00:08:29,620 --> 00:08:34,440
+وفيه إشي اللي دخل بالـ Beta Globulin Genes وفيه
+
+88
+00:08:34,440 --> 00:08:39,320
+خمسة منهم ولمّا نيجي نقرأه، نقرأ بهذا الشكل وبكون
+
+89
+00:08:39,320 --> 00:08:48,100
+هكذا فهذا تركيب الـ DNA وتركيبه على مستوى أول شيء
+
+90
+00:08:48,100 --> 00:08:52,560
+على مستوى الكرمозوموعلى مستوى الـ Bands تبعة الـ
+
+91
+00:08:52,560 --> 00:09:01,120
+Chromosome وعلى مستوى بعدين اللي بنسميه القراءة
+
+92
+00:09:01,120 --> 00:09:04,200
+الدقيقة تبعته اللي بنسميها الـ Sequencing تبعته
+
+93
+00:09:04,200 --> 00:09:10,100
+فهذه درجات تعقيد الموضوع وبالتالي، بدل واحد يكون
+
+94
+00:09:10,100 --> 00:09:19,180
+متنبه لها نذكر مرة ثانية إنه مقارنة بالـ DNAاللي
+
+95
+00:09:19,180 --> 00:09:23,040
+هو الـ Deoxyribonucleic Acid اللي فيه الـ
+
+96
+00:09:23,040 --> 00:09:30,240
+Deoxyribose كشجر وفسفيت والأربع نيوكليك أسد أو
+
+97
+00:09:30,240 --> 00:09:36,220
+الأربع نيتروجينيس بايزيز اللي هي الـ Purines
+
+98
+00:09:36,220 --> 00:09:43,900
+والبريمدين الـ RNA تركيبه مختلف في ناحيتين أساسية
+
+99
+00:09:43,900 --> 00:09:49,520
+أول شيءإن الشجر هو الـ «ريبوز» وليس الـ
+
+100
+00:09:49,520 --> 00:09:56,500
+«أكسيريبوز» البدل للثامين
+
+101
+00:09:56,500 --> 00:10:04,140
+في الـ «نيوراسيل» كـ «نيتروجينس بيس» وطبعًا يتغير
+
+102
+00:10:04,140 --> 00:10:09,280
+إنه في الجسم بشكل طبيعي أو في غالبية الوقت بشكل
+
+103
+00:10:09,280 --> 00:10:18,000
+طبيعي يكون على شكل Single Strandمن دراسة الأمراض
+
+104
+00:10:18,000 --> 00:10:22,140
+اللي هي زي الـ «Autoimmune Diseases» أمراض المناعة
+
+105
+00:10:22,140 --> 00:10:26,960
+الداتية اللي فيه عنا Double-Stranded RNA ممكن
+
+106
+00:10:26,960 --> 00:10:33,960
+يتشكل بشكل صناعي Single-Stranded DNA يعني بتلاقي
+
+107
+00:10:33,960 --> 00:10:39,280
+فيه إنه أنا ممكن يكون عندي أنواع أخرى ففي حد عنده
+
+108
+00:10:39,280 --> 00:10:46,240
+سؤال so farهذه اللي هي الاختلافات بين الـ «RNA»
+
+109
+00:10:46,240 --> 00:10:52,720
+والـ «DNA» الـ «DNA» بيظلوا جوا النواء الـ
+
+110
+00:10:52,720 --> 00:11:00,920
+«Nucleus» الـ «RNA» بيتم Transcription له بيكون هو
+
+111
+00:11:00,920 --> 00:11:07,330
+لسه جوا النواء بيتم عملية قص و لصق لهبحيث إن
+
+112
+00:11:07,330 --> 00:11:12,430
+الـFull Messenger RNA المطلوب هو اللي بتتم إخراجه
+
+113
+00:11:12,430 --> 00:11:21,150
+فهنا أمثلة على إنه إحنا كتير في قضايا البروتينات
+
+114
+00:11:21,150 --> 00:11:27,870
+اللي بتكون مفيدة في الجسم وضرورية بتتم من خلال
+
+115
+00:11:27,870 --> 00:11:34,750
+استخدام قطعة كثيرة من الـDNA
+
+116
+00:11:34,750 --> 00:11:42,030
+بحيث إنهالمنطقة اللي يتم استخدامها في عمل البروتين
+
+117
+00:11:42,030 --> 00:11:47,510
+بسميها الـ Exon بسبب أن مثلًا هذه القطعة بدها
+
+118
+00:11:47,510 --> 00:11:53,670
+مثلًا أول بروتين مثلًا هذا له أربع Exons مثلًا أي
+
+119
+00:11:53,670 --> 00:11:59,870
+هنا فوق واللي بينهم بنسميه الـ Introns اللي هم يتم
+
+120
+00:11:59,870 --> 00:12:08,890
+قصهم ويعني رميهموبكون يعني لقليات أو لهدف يعني ما
+
+121
+00:12:08,890 --> 00:12:15,290
+بأعرفه الآن بس إحنا الـ «هي» بتكون step أو مرحلة
+
+122
+00:12:15,290 --> 00:12:19,490
+ضرورية في صناعة كثير من البروتينات إنه بتكون أكثر
+
+123
+00:12:19,490 --> 00:12:26,770
+من قطعة وبتعطينا تحكم أكبر في ناتج البروتيني من
+
+124
+00:12:26,770 --> 00:12:31,090
+هذا الـGene فالـ«هي» بشكل عام
+
+125
+00:12:33,890 --> 00:12:40,390
+حتى القليات عملية الـ Transcription للـ DNA into
+
+126
+00:12:40,390 --> 00:12:48,150
+RNA تبدأ بدها تكون أول شيء تتعرف على نقطة اللي هي
+
+127
+00:12:48,150 --> 00:12:53,210
+حاطينها هنا بالأول اسمها Start of Transcription
+
+128
+00:12:53,210 --> 00:13:01,390
+يعني في عادة لكل جين في منطقة في مقدمتهبكون الـ
+
+129
+00:13:01,390 --> 00:13:07,370
+Transcription Mechanism الميكانيكيات أو آليات
+
+130
+00:13:07,370 --> 00:13:15,470
+العمل بتفهموا إنه ابدأ من هنا وراح يكون إن
+
+131
+00:13:15,470 --> 00:13:21,190
+الـInitiator Codon اللي هو الـCodon اللي هو ثلاثي
+
+132
+00:13:21,190 --> 00:13:26,430
+الـNucleotides بترتيب معين بتقول ابدأ هنا فبيبدأ
+
+133
+00:13:26,430 --> 00:13:31,910
+يقرأوهذه الـ Direction of Transcription لحد ما يصل
+
+134
+00:13:31,910 --> 00:13:37,550
+بالأخير إلى الـ Termination Codon اللي يقول له
+
+135
+00:13:37,550 --> 00:13:44,510
+واقف هنا وبعدين حتى يحميه ويمشي خطوات أخرى بيكون
+
+136
+00:13:44,510 --> 00:13:50,930
+فيه Untranslated Region و Polyadenylation Signal
+
+137
+00:13:50,930 --> 00:13:56,230
+وفي أشياء إضافية حتى تساعد في عملية التحكمفي
+
+138
+00:13:56,230 --> 00:14:02,010
+الـTranscription إلى الـTranslation إلى الـProtein
+
+139
+00:14:02,010 --> 00:14:07,850
+synthesis فمثلًا، دكتور، دكتور، نعم ففي بس سؤال من
+
+140
+00:14:07,850 --> 00:14:12,570
+دكتور هديل نعم بخصوص مستويات تركيب الـDNA نعم
+
+141
+00:14:12,570 --> 00:14:17,510
+بتقول، على أي أساس صاروا الثلاثة؟ لأ، إحنا لما
+
+142
+00:14:17,510 --> 00:14:24,790
+نتكلم عن الـDNA هو نفسه خط طويليعني بيقولّك إذا
+
+143
+00:14:24,790 --> 00:14:30,110
+بتلفيه Single Nucleotides واحد ورا الثاني، بيلف
+
+144
+00:14:30,110 --> 00:14:35,050
+الكورة الأرضية، ماشي؟ فأنا إذا بدي أتخيل كيف بدي
+
+145
+00:14:35,050 --> 00:14:38,950
+أتعامل معاه، ممكن أنا بكون في مرحلة معينة، في لحظة
+
+146
+00:14:38,950 --> 00:14:44,230
+معينة، بتكلم عن كرومزومات، فهو أي جين موجود على
+
+147
+00:14:44,230 --> 00:14:49,880
+كرومزوم معينففي أحداث ترتبط بالـ Chromosomes والـ
+
+148
+00:14:49,880 --> 00:14:53,980
+Chromosomes مهمة بهذا الشكل المضغوط اللي بنشوفه في
+
+149
+00:14:53,980 --> 00:14:58,100
+هذه اللحظة يعني هو الـ Chromosome مارحش ماشي، بس
+
+150
+00:14:58,100 --> 00:15:06,500
+شكله زي يعني خيط فالت ومش ملفوف بقى بالـ Pistons
+
+151
+00:15:06,500 --> 00:15:12,200
+بشكل مضغوط كتير الدغطة الشديدة هي أنا بديها وقت
+
+152
+00:15:12,200 --> 00:15:19,360
+الـ Cell Divisionفوقتها بحتاج الكروموزوم يكون بهذا
+
+153
+00:15:19,360 --> 00:15:24,960
+الشكل اللي هو حاطناه فوق فلما أنا أشوفه بهذا الشكل
+
+154
+00:15:24,960 --> 00:15:30,080
+هنا بالمتوسط كلنا كل كروموزوم فيه حوالي ألف جين
+
+155
+00:15:30,080 --> 00:15:34,860
+فأنا مقدرش أتعامل مع الألف جين أحياناً فيه ظواهر
+
+156
+00:15:34,860 --> 00:15:42,860
+وأمراض وحالات بتكون قطعة منه بسومرات الكرموزومات
+
+157
+00:15:42,860 --> 00:15:45,940
+زي ما هنا حاطين بيسموها الـ Binding هذا الـ
+
+158
+00:15:45,940 --> 00:15:54,280
+Binding هي مرتبط بكم عدد الجينات في هذه القطعة من
+
+159
+00:15:54,280 --> 00:16:01,320
+الـ DNA أو من الكرموزوم وبعدين بدرجة أدق يعني الـ
+
+160
+00:16:01,320 --> 00:16:08,000
+Binds إشي جاي بالنص يعني هذا الآن اللي يعني ده
+
+161
+00:16:08,000 --> 00:16:15,150
+بدنا نتخيل هناالـ Chromosome هذا حوالي ألف جين الـ
+
+162
+00:16:15,150 --> 00:16:18,410
+Band الوحدي هنا اللي حاطينا هي عبارة عن خمستاشر
+
+163
+00:16:18,410 --> 00:16:23,330
+جين بس بس بعدين لما أدخل أنا بالتفصيل طبعاً هنا
+
+164
+00:16:23,330 --> 00:16:29,630
+الـ Chromosome هذا مقسم حوالي مثلاً نقول ثلاثين
+
+165
+00:16:29,630 --> 00:16:35,770
+Band كل Band مثلاً فيها عشرين، ثلاثين جينوالجين
+
+166
+00:16:35,770 --> 00:16:40,890
+الواحد لسه كمان له تعقيد جوا زي اللي بنشوفه هنا
+
+167
+00:16:40,890 --> 00:16:47,750
+فأنا بتكلم على إنه الواحد لازم يكون هيك لما نقرا
+
+168
+00:16:47,750 --> 00:16:54,710
+أي معلومة ماشي، بده هيك بسرعة يفهم شو المقصود من
+
+169
+00:16:54,710 --> 00:16:58,910
+الكلام هذا اللي هو احنا بنتكلم على مستوى كـ
+
+170
+00:16:58,910 --> 00:17:04,360
+Chromosome في Band معينةنتحدث عن نفس الـ «جين»
+
+171
+00:17:04,360 --> 00:17:12,240
+اللي سنتحدث عنه مثلًا مثلًا الـ «FMF» الـ «Family
+
+172
+00:17:12,240 --> 00:17:19,960
+Mediterranean Fever» أبارعًا «جين» حوالي نتحدث عن
+
+173
+00:17:19,960 --> 00:17:26,540
+مركب اسمه الـ «بايرين» فيه حوالي 11 «كودون» 11 أسف
+
+174
+00:17:26,540 --> 00:17:33,550
+«إكزون» يعني فيه11 قطعة يتم قرائتها ولسقة وفيها
+
+175
+00:17:33,550 --> 00:17:40,210
+حوالي عشرة بالنص راح يطيروا الآن الـ FMF هي عبارة
+
+176
+00:17:40,210 --> 00:17:50,050
+عن مشكلة في الـ Exons رقم 2 ورقم 10 دواهر اللي
+
+177
+00:17:50,050 --> 00:17:55,670
+عنده يعني لو واحد عنده mutation في Exons تانين
+
+178
+00:17:55,670 --> 00:18:04,740
+مايكونش عنده مرض فاحنا نتكلم علىالآن وصف لمستويات
+
+179
+00:18:04,740 --> 00:18:11,240
+البعد عن نظر على تركيب الـDNA يعني بدأ حدا منكم
+
+180
+00:18:11,240 --> 00:18:17,660
+يستخدم مثلًا Google Earth ماشي، لما أنت تتفرج من
+
+181
+00:18:17,660 --> 00:18:21,120
+ارتفاع عالي جدًا جدًا جدًا على كل الكورة الأرضية
+
+182
+00:18:21,120 --> 00:18:28,150
+يمكن كل القارة دوبة تشوفها بمستوى واحدبعدين بتنزل
+
+183
+00:18:28,150 --> 00:18:33,690
+بشكل أدق بتصير مثلًا بلد زي فلسطين أو الأردن
+
+184
+00:18:33,690 --> 00:18:37,690
+بتتبين كلها في الشاشة بحيث أنه بتصير القرى
+
+185
+00:18:37,690 --> 00:18:44,370
+والأسماء المدن تتبين أكثروبعدين بتدخل بدقة أكثر،
+
+186
+00:18:44,370 --> 00:18:48,930
+بتصير مثلا والله صورة الشارع، صورة البيت، صورة
+
+187
+00:18:48,930 --> 00:18:53,830
+الكذا فأنا بتتكلم على مستويات ثلاثة أنا بالنسبة
+
+188
+00:18:53,830 --> 00:18:58,190
+إلي، بشبهها أنه عن إيش أنت بتتكلم على مستوى
+
+189
+00:18:58,190 --> 00:19:01,730
+الـChromosome، على مستوى Band في الـChromosome
+
+190
+00:19:01,730 --> 00:19:05,570
+وفيه حوالي مثلا تلاتين، أربعين، أشرين، أقل أكثر
+
+191
+00:19:05,570 --> 00:19:10,940
+Bandوبعدين كل Band فيها عدد من الجينات وبعدين لما
+
+192
+00:19:10,940 --> 00:19:16,060
+تدخل في الجين مثلًا، هذولة ثلاث جينات بيحطونها الـ
+
+193
+00:19:16,060 --> 00:19:21,180
+Beta-Globulin تبع الـHemoglobin اللي هو تبع الـ…
+
+194
+00:19:21,180 --> 00:19:24,000
+المعروفين الـ2-Alpha-Chain و2-Beta-Chain وفيه
+
+195
+00:19:24,000 --> 00:19:32,120
+Braca، هذا عبارة عن جين مسئول إذا في خلل عن حدوث
+
+196
+00:19:32,120 --> 00:19:38,080
+الـCancerفبراكا I وبراكا II، براكا I يعني إحنا راح
+
+197
+00:19:38,080 --> 00:19:43,780
+ناخد بعدين أمثلة عليها وفي الـmyocardial heart
+
+198
+00:19:43,780 --> 00:19:49,780
+muscle gene نسمينه MyH7 اللي دخل
+
+199
+00:19:49,780 --> 00:19:54,160
+بالـcardiomyopathy inherited hypertrophic
+
+200
+00:19:54,160 --> 00:20:00,040
+cardiomyopathy فالآن هذا أنا بتكلم على مستوى
+
+201
+00:20:00,040 --> 00:20:07,430
+الـDNAأنا بتكلم الـ Globulin part مثلًا بيبدأ هون
+
+202
+00:20:07,430 --> 00:20:14,990
+يلو ثلاث Exons فيه Two Introns اللي بالنص هذول
+
+203
+00:20:14,990 --> 00:20:20,350
+اللي راح يطيروا وهونا البداية وهونا النهاية
+
+204
+00:20:20,350 --> 00:20:28,410
+البراكا البراكا يعني انتوا كل هذه الأشياء يمكنيعني
+
+205
+00:20:28,410 --> 00:20:32,330
+إذا الواحد ما بيربطاش القصة هيكي بتفتكره في حالة،
+
+206
+00:20:32,330 --> 00:20:39,550
+في حاجة يعني هذا عبارة عن جيل مشهور جداً لإصابات
+
+207
+00:20:39,550 --> 00:20:44,150
+سرطان الثدي وسرطان الرحم عند النساء بالذات وهذه
+
+208
+00:20:44,150 --> 00:20:49,110
+ممثلة مشهورة جداً في العالم Angelina Jolie هذه
+
+209
+00:20:49,110 --> 00:20:55,070
+اللي عمل فير ولي أفلامها، لو حدا كان شاب فالمريضة
+
+210
+00:20:55,070 --> 00:20:57,430
+هذه والدتها في عندها
+
+211
+00:21:03,710 --> 00:21:08,990
+عشان هي عملت بيلاترال مستكتومي على ضوء إنه طلع الـ
+
+212
+00:21:08,990 --> 00:21:15,450
+mutation في هذا الجين موجود ففيه جين اسمه Braca
+
+213
+00:21:15,450 --> 00:21:23,970
+إله دخل بالكانسر والـ MyH7 إله حالة دخل في حالة
+
+214
+00:21:23,970 --> 00:21:29,730
+اللي هيتضخم عضلة القلب بحيث أنه تلاقي اللي إذا
+
+215
+00:21:29,730 --> 00:21:33,990
+بتلاقي بيقولك لاعب كرة قدم وهو صغير ماعندهوش سكري
+
+216
+00:21:33,990 --> 00:21:39,430
+ولا ضغط فجأة الطب كله الطب ساكن فبيصير عنده افتلال
+
+217
+00:21:39,430 --> 00:21:44,970
+في نظم القلب بيصير عندهم وفاة مفاجئة وبيقول أنه
+
+218
+00:21:44,970 --> 00:21:49,470
+دخل في حالة ورافية اللي هي الحالة اللي بتكون
+
+219
+00:21:49,470 --> 00:21:53,560
+حالتها يعني أحياناًتضخم القلب هذا، بيكون مش وراثي
+
+220
+00:21:53,560 --> 00:21:57,440
+بس الحالة الوراثية بتكون إلها دخل بهذا الـGene
+
+221
+00:21:57,440 --> 00:22:03,280
+ملاحظة يعني أخيرًا تبقوا عليها تفضل اللي هي إن
+
+222
+00:22:03,280 --> 00:22:07,360
+أسماء الجينات لما نحكي عن الجينات بيحطوها كلها
+
+223
+00:22:07,360 --> 00:22:11,900
+Capital Letters في النهاية لما يقعدوا يشرحوا على
+
+224
+00:22:11,900 --> 00:22:16,280
+إن الشغل الإفلاني بيحط لكيها كلها Capital فهو قصده
+
+225
+00:22:16,280 --> 00:22:22,000
+الـGene، ماشي؟ في سؤال ثاني اسألهفي سؤال من
+
+226
+00:22:22,000 --> 00:22:26,060
+الدكتورة أسماء بخصوص الـ«بولي أدينالياشن» بتقول
+
+227
+00:22:26,060 --> 00:22:32,180
+أنه أخدوا قبل ذلك أن يتم إضافة الـNucleotide A بعد
+
+228
+00:22:32,180 --> 00:22:36,460
+عملية إزالة الانترون ولكن في الصورة بيتم إضافة
+
+229
+00:22:36,460 --> 00:22:44,620
+الـA قبل إزالة الانترون والله في الصورة مبين إنه
+
+230
+00:22:44,620 --> 00:22:46,400
+في الـ«أدينالياشن» Signal
+
+231
+00:22:49,050 --> 00:22:54,190
+موجودة قبل ما يتم عملية تقطيع الـ Exons؟ يمكن،
+
+232
+00:22:54,190 --> 00:23:00,670
+يمكن، أنا، شوف، مية بالمية، بلاش ندخل التفاصيل،
+
+233
+00:23:00,670 --> 00:23:06,110
+أنا ماعندي علم أقولك هيك بيصير أو هيك بيصيرش، بس
+
+234
+00:23:06,110 --> 00:23:13,350
+الملاحظ يعني لما تيجي الصورة هذه ماشية، اللي هي
+
+235
+00:23:13,350 --> 00:23:20,180
+بتتكلم أكثر عن الناحية هذه،إنه بطريقة ما الـ
+
+236
+00:23:20,180 --> 00:23:25,640
+«high» على مستوى الـ «DNA» بدّك تفرطه وتبعده عن
+
+237
+00:23:25,640 --> 00:23:31,680
+بعض حتى تفعل الـ Transcription وتمشي من الـ «5
+
+238
+00:23:31,680 --> 00:23:36,920
+End» لـ «3 End» دائماً، من «5 Prime» لـ «3 Prime»
+
+239
+00:23:36,920 --> 00:23:42,630
+ففي هنا الـ «Startup»وفي الـ Promoter Region الـ
+
+240
+00:23:42,630 --> 00:23:46,930
+Promoter Region شوية منطقة أقعد شوية لقدام واللي
+
+241
+00:23:46,930 --> 00:23:51,690
+قصد فيها إنها تنبه الـ Transcription Mechanism
+
+242
+00:23:51,690 --> 00:23:55,510
+هاليات الـ Transcription إنه ابدأ من هون، فيه هنا
+
+243
+00:23:55,510 --> 00:24:00,190
+إشي وفي الـ Startup Codon اللي هو بيقولك ابدأ هنا
+
+244
+00:24:00,190 --> 00:24:09,700
+فبتم نسخ الـ RNAكله بما فيه الـ Exon اللي هم هذولة
+
+245
+00:24:09,700 --> 00:24:15,880
+المفيدات والـ Intron اللي بدهم انقطعه وبتم إضافة
+
+246
+00:24:15,880 --> 00:24:24,940
+بعدين «ذيل» ماشي أنا بفهم إن هذا يتم الاستفادة منه
+
+247
+00:24:24,940 --> 00:24:32,760
+في قضية تحريك الـ Messenger RNA خارج النواة الـ
+
+248
+00:24:32,760 --> 00:24:38,180
+Transcriptionبيكون خلال النواة والـAlternative
+
+249
+00:24:38,180 --> 00:24:44,480
+Splicing أو Processing of the RNA بحيث إنه هذولة
+
+250
+00:24:44,480 --> 00:24:52,200
+الـIntrons بتم قصهم والـExons بتم وصلهم مع بعض،
+
+251
+00:24:52,200 --> 00:24:55,840
+بحيث يعطيني هذا اللي راح يكون مسؤول عن البروتين
+
+252
+00:24:55,840 --> 00:25:01,060
+النهائي، هذا يعني الله أعلم يمكن الـPoly-A tail
+
+253
+00:25:02,850 --> 00:25:10,910
+مطلوب عشان يتم سهولة تخريجه من النواة حتى يدخل
+
+254
+00:25:10,910 --> 00:25:14,250
+الـCytoplasm ويروح على الـRough Endoplasmic
+
+255
+00:25:14,250 --> 00:25:19,250
+Reticulum ويروح على غيره ويقدر بعدين يجي جنبه
+
+256
+00:25:19,250 --> 00:25:27,050
+الـRibosome اللي راح زي سحاب البنطلون أو سحاب
+
+257
+00:25:27,050 --> 00:25:35,020
+الجاكيت أحيانًا ولا إشيبصير، بمسك الـ الـ كل ثلاثة
+
+258
+00:25:35,020 --> 00:25:39,240
+الـ nucleotides وبيقراهم وبيحط الـ amino acid
+
+259
+00:25:39,240 --> 00:25:44,280
+اللازم لحيث إنه بيبني الـ amino acid chain
+
+260
+00:25:44,280 --> 00:25:48,440
+المطلوبة اللي هي الـ growing polypeptide chain
+
+261
+00:25:48,440 --> 00:25:54,540
+فالـ الـ الـ terminal poly-A addition ماشي، ظاهرة
+
+262
+00:25:54,540 --> 00:26:02,660
+بتحدث والله ما بعرف شو هميتها100% يعني ما بعرف إذا
+
+263
+00:26:02,660 --> 00:26:08,700
+في مثلًا ناس عندهم أمراض نتيجة إنها لا تتم أو شو
+
+264
+00:26:08,700 --> 00:26:12,240
+دورة، بس هاي شغلة يعني الله العليم إنها لكل
+
+265
+00:26:12,240 --> 00:26:15,760
+الجينات أو لعدد كبير من الجينات، بلاش أقول كل
+
+266
+00:26:15,760 --> 00:26:27,040
+الجينات، واضح؟ في أسئلة؟فهذه الظواهر اللي الواحد
+
+267
+00:26:27,040 --> 00:26:37,700
+بده يتذكرها الـ Expression أو المظهريًا الجين
+
+268
+00:26:37,700 --> 00:26:44,960
+مسؤول عن البروتين وبتم هذه المسؤولية وبتم هذه
+
+269
+00:26:44,960 --> 00:26:51,400
+الظاهرة من خلال الخطوات
+
+270
+00:26:51,400 --> 00:26:57,980
+هذه Transcriptionوبعدين RNA Processing تقوم هنا
+
+271
+00:26:57,980 --> 00:27:01,420
+بالـ Transport لازم تكون من جوه الخلية لبره الخلية
+
+272
+00:27:01,420 --> 00:27:05,840
+بيصير عندى عملية الـ Translation من الـ Messenger
+
+273
+00:27:05,840 --> 00:27:10,700
+RNA لـ Polypeptide Chain وبعدين بيصير عند الـ
+
+274
+00:27:10,700 --> 00:27:13,840
+Protein Assembly اللي هو راح يقدّل وظيفة، راح
+
+275
+00:27:13,840 --> 00:27:20,040
+يقدّل الشيء المطلوب، ماشي؟ هاي اللي يعني سموها هو
+
+276
+00:27:20,040 --> 00:27:23,620
+هنا الـ Flow of Informationمن ديانات وارانات
+
+277
+00:27:23,620 --> 00:27:33,080
+وبروتين على إشي افتراضي، ماشي؟ الآن،
+
+278
+00:27:33,080 --> 00:27:40,940
+كيف الـDNA مسئول عن البروتين؟
+
+279
+00:27:40,940 --> 00:27:48,360
+نتذكر إن أنا عندي أربع نيكليك أسند أو نيكليوتايد
+
+280
+00:27:48,360 --> 00:27:53,710
+أو Nitrogenous basesفالأربعة الـ Nucleotides طبعًا
+
+281
+00:27:53,710 --> 00:28:00,650
+جايين بترتيب إنه كل واحد لازم يقابله إش محدد فإحنا
+
+282
+00:28:00,650 --> 00:28:05,130
+بنحكي عن صف واحد، من جهة واحدة لسه اللي هي من
+
+283
+00:28:05,130 --> 00:28:10,430
+الخمسة للثلاثة اللي راح يكون من خلالها عملية
+
+284
+00:28:10,430 --> 00:28:18,650
+القراءة بهذا الترتيب نتذكر شغلة أول شيء استنتجوها
+
+285
+00:28:18,650 --> 00:28:28,170
+حسابياًوبعدين تبدأ بالواقع وبالمشاهدات وبالتجارب
+
+286
+00:28:28,170 --> 00:28:34,370
+وكذا لو افترضنا طبعاً أنا بعرف أنه أنا كـ Protein
+
+287
+00:28:34,370 --> 00:28:41,870
+Structure في عندي 20 Amino Acids وهي أساميهم ويلهم
+
+288
+00:28:41,870 --> 00:28:47,170
+طريقة كتابتهم وراح نقرأ عنهم بعدين في ثلاث طرق
+
+289
+00:28:47,170 --> 00:28:54,190
+ممكننحط ثلاث أحرف «لوسين» هذا الإسم الكامل تبعه
+
+290
+00:28:54,190 --> 00:28:59,650
+وفي أحيانًا بيرمزوا للـ Amino Acid بحرف واحد اللي
+
+291
+00:28:59,650 --> 00:29:05,490
+هو الـ «L» لما نحطه «K» اللي هو الـ «Lysine» هذا
+
+292
+00:29:05,490 --> 00:29:10,550
+اسمه، هذا كلهم Amino Acids طبعًا الـ Amino Acid
+
+293
+00:29:10,550 --> 00:29:15,920
+Structure لازم تكونوا عارفين فيالـ Carboxyl
+
+294
+00:29:15,920 --> 00:29:20,120
+Terminal وفي الـ Nitrogen Terminal في الـ N
+
+295
+00:29:20,120 --> 00:29:25,660
+Terminal يعني الـ Backbone يعني إشي قريب من الـ من
+
+296
+00:29:25,660 --> 00:29:32,020
+الـ DNA يعني إذا تخيلنا الـ DNA الـ DNA ديوكسي
+
+297
+00:29:32,020 --> 00:29:36,380
+رايبوز فوسفيت ديوكسي رايبوز فوسفيت ديوكسي رايبوز
+
+298
+00:29:36,380 --> 00:29:42,820
+فوسفيت وفي النصر بينهم في الـ Nitrogen Space بس
+
+299
+00:29:42,820 --> 00:29:49,120
+الـالـ Amino Acids ماشي، عبارة عن فيه Carboxyl
+
+300
+00:29:49,120 --> 00:29:54,660
+Terminal اللي دايماً بنبدأ بيبدو بالـ N Terminal
+
+301
+00:29:54,660 --> 00:29:59,720
+اللي هي البداية وبيجي بعدين الـ Carboxyl Terminal
+
+302
+00:29:59,720 --> 00:30:06,440
+تبعتها بالطرف فيه Side Chain Side Chain هي اللي هي
+
+303
+00:30:06,440 --> 00:30:12,120
+بتسوي الاختلافات بين الـ Amino Acids ففي عندنا
+
+304
+00:30:12,120 --> 00:30:18,430
+Structure متكرراللي هو Nitrogen-based terminal
+
+305
+00:30:18,430 --> 00:30:22,270
+وCarboxyl terminal نيتروجين تيرمينال وCarboxyl
+
+306
+00:30:22,270 --> 00:30:26,710
+terminal والـ Side Chain هم اللي بيعطينا الخواص
+
+307
+00:30:26,710 --> 00:30:31,110
+الأخرى والتفاعلات الأخرى والأشياء هذه فأنا بما أنه
+
+308
+00:30:31,110 --> 00:30:35,330
+أنا عندي، هذه مراجعة شوية للـBiochemistry بما أنه
+
+309
+00:30:35,330 --> 00:30:42,470
+أنا عندي أشرين Amino Acid لو كان كل Amino Acid هو
+
+310
+00:30:42,470 --> 00:30:48,560
+نتيجةقراة نيكليوتايد واحد أو Nitrogen Base واحدة
+
+311
+00:30:48,560 --> 00:30:53,700
+كان راح يكون إنه أنا عندي أربع Nitrogen Bases راح
+
+312
+00:30:53,700 --> 00:31:00,560
+يكونوا مسئولين عدفة عن أربع Amino Acids بالتالي،
+
+313
+00:31:00,560 --> 00:31:08,160
+ما بظبط، ما راح يكون كافي، فلو كنا أثنينالـ2 إبارة
+
+314
+00:31:08,160 --> 00:31:12,780
+عن 4×4 صارت الاحتماليات أحسن بل الـ16 لسة ما بيكفي
+
+315
+00:31:12,780 --> 00:31:24,500
+الـ20 أمائن واسر فكانت النتيجة أنه فعليًا
+
+316
+00:31:24,500 --> 00:31:31,320
+كل 3 أماء الـNitrogenous Bases كل 3 نيكليوتايد
+
+317
+00:31:31,320 --> 00:31:35,760
+بالترتيب اللي هم موجودين فيه بيكونوا مسؤولين عن
+
+318
+00:31:37,960 --> 00:31:44,900
+بتحديد الـ Amino Acid المطلوب إذا أخذنا أربعة
+
+319
+00:31:44,900 --> 00:31:50,240
+بأربعة بأربعة بيصير عندي أربعة وستين، شو اسمه؟
+
+320
+00:31:50,240 --> 00:31:56,280
+أربعة وستين possibility
+
+321
+00:31:56,280 --> 00:32:01,340
+والأربعة وستين، عشان يـCalculate عشرين Amino
+
+322
+00:32:01,340 --> 00:32:08,630
+Acids، راح تلاحظ أنهكل أحيانًا أكثر من كودون أكثر
+
+323
+00:32:08,630 --> 00:32:13,890
+من ثلاث من الـNucleotides ورا بعض لما تجيب ترتيب
+
+324
+00:32:13,890 --> 00:32:20,850
+معين روح تتأشرنا على نوع معين من الـAmino Acids
+
+325
+00:32:20,850 --> 00:32:27,670
+فهذا جدول اللي هم ترتيب الكودونات، ماشي؟ وكل واحد
+
+326
+00:32:27,670 --> 00:32:33,570
+شو يمثل كـAmino Acid فمثلًا إذا جبنا إن أنا عندي
+
+327
+00:32:34,040 --> 00:32:41,240
+AAA رح هذا يعطينا الـ Lysine إذا AAG كمان رح
+
+328
+00:32:41,240 --> 00:32:48,380
+يعطينا الـ Lysine مثلاً هذا الـ Leucine UUA بعطينا
+
+329
+00:32:48,380 --> 00:32:52,840
+الـ Leucine UUG بعطينا الـ Leucine CUU بعطينا الـ
+
+330
+00:32:52,840 --> 00:32:59,740
+Leucine فهك تطلعوا عليه راح تلاقي إنه بالأخير هناك
+
+331
+00:32:59,740 --> 00:33:03,480
+العشرين amino acid فيه كل واحد منه على الأقل له
+
+332
+00:33:04,190 --> 00:33:10,010
+Codon معين، ثلاثة معينة ورا بعض تعطيك إيش هو الـ
+
+333
+00:33:10,010 --> 00:33:17,030
+Amino Acid اللازم بالإضافة لإذا إنتبهت هنا في كمان
+
+334
+00:33:17,030 --> 00:33:22,550
+واحد اسمه Stop Codon يعني عبارة عن إشي إذا الـ
+
+335
+00:33:22,550 --> 00:33:28,030
+Mechanism تبع القراءة شافها «UAA» معناه تـStop
+
+336
+00:33:28,030 --> 00:33:34,720
+«UAG» معناه تـStop «UGA» برضه Stopوفيه مفروض واحدة
+
+337
+00:33:34,720 --> 00:33:42,020
+تكون Start، ماشي، بحاول أطلع عليها بس شكلها صعب أو
+
+338
+00:33:42,020 --> 00:33:49,960
+مانيش شايفها، ففيه ال .. ال .. يعني لازم يكون فيه
+
+339
+00:33:49,960 --> 00:33:53,400
+startup
+
+340
+00:33:53,400 --> 00:34:00,320
+codon، يعني Start، وفيه إشي لل Stop، حتى الـ «AOG»
+
+341
+00:34:00,320 --> 00:34:06,530
+يا دكتور، الـ Start Codonعادةً بتكون، عادةً بتكون،
+
+342
+00:34:06,530 --> 00:34:12,510
+أه، مش شايفة بالجدول اللي حاطينه، ماشي، فالمهم،
+
+343
+00:34:12,510 --> 00:34:15,690
+موجود، موجود، موجود مع الـ، مع وجود قبال
+
+344
+00:34:15,690 --> 00:34:23,430
+المثيونين، أه، المهم، يعني الفكرة أنه اللي لما
+
+345
+00:34:23,430 --> 00:34:28,860
+نيجي نقرأ، اللي لما نعمل بنسميهالـ... نقرأ الـ...
+
+346
+00:34:28,860 --> 00:34:33,880
+الـNucleotides تبعات الـDNA لقطع الـDNA في الـGene
+
+347
+00:34:33,880 --> 00:34:36,620
+أو في غيره أو Whole Genome Sequence نسميها
+
+348
+00:34:36,620 --> 00:34:42,480
+Sequencing بدي أنتباه إنه كل ثلاثة راح يعطينا
+
+349
+00:34:42,480 --> 00:34:47,520
+مقابلها Amino Acid فهنا يعني فيه ظواهر كتيرة راح
+
+350
+00:34:47,520 --> 00:34:52,880
+تتمني إحنا اللي اتكلمنا المرة اللي فاتت على قضية
+
+351
+00:34:52,880 --> 00:35:03,430
+إنه الـعلى قضية إنه أحيانًا لو فيه ND-SNP اللي هو
+
+352
+00:35:03,430 --> 00:35:07,530
+الـ Single Nucleotide Polymorphism أحيانًا مالهاش
+
+353
+00:35:07,530 --> 00:35:13,590
+قيمة يعني، Okay، فيه اختلاف بين ترتيب الـ
+
+354
+00:35:13,590 --> 00:35:20,010
+Nucleotides في جين معين في قرايتها في حالة معينة
+
+355
+00:35:20,010 --> 00:35:25,430
+بين شخص وشخص تانيوبس هاي بالأخير على مستوى وظيفي
+
+356
+00:35:25,430 --> 00:35:29,970
+على مستوى شكل البروتين على شكل وظيفة البروتين
+
+357
+00:35:29,970 --> 00:35:39,030
+بعدين قد لا يكون هناك قيمة كثيرة فإذا افترضنا هذه
+
+358
+00:35:39,030 --> 00:35:43,670
+موجودة هنا الـ ATG مثلاً اعتبرناها Start Codon
+
+359
+00:35:43,670 --> 00:35:50,480
+الواحد بده ينتبه، ماشيقضية إنه بالأخير إحنا كل
+
+360
+00:35:50,480 --> 00:35:55,380
+ثلاثة نقراهم مع بعض أكبر كارثة راح تصير في جهة
+
+361
+00:35:55,380 --> 00:36:01,140
+كلها النظام إنه لو واحد أو اثنين نيكليوتيز يصيرهم
+
+362
+00:36:01,140 --> 00:36:06,020
+«Deletion» هذا راح يخبص الدنيا ويخربط الدنيا لأن
+
+363
+00:36:06,020 --> 00:36:11,440
+كل اللي بعده راح يصير غير مفهوم، ماشي؟ فهذه ظاهرة
+
+364
+00:36:11,440 --> 00:36:15,840
+بتحدث، فإحنا هنا يعني إذا افترضنا هذا الـDNA الأول
+
+365
+00:36:16,810 --> 00:36:20,410
+رح يصير عملية الـ Transcription رح يطلعني
+
+366
+00:36:20,410 --> 00:36:25,930
+Messenger RNA هذا بالأول قالله ابدأ هنا الـ
+
+367
+00:36:25,930 --> 00:36:31,510
+Messenger RNA هيه الترتيب طلع مكافئ للي قبل لما
+
+368
+00:36:31,510 --> 00:36:36,690
+نعمل عملية الـ Translation بتصير لازم تكون ثلاثيات
+
+369
+00:36:36,690 --> 00:36:43,520
+فمن أول ما بيبدأ كل ثلاثة بنصير ينقرنيعني هو أنا
+
+370
+00:36:43,520 --> 00:36:49,200
+أظن بالين، هستين، لوسين، ثرونين، برولين، جليسين،
+
+371
+00:36:49,200 --> 00:36:54,060
+كذا، فبصير الـ Transcription، الـ Translation اللي
+
+372
+00:36:54,060 --> 00:36:58,420
+بعطينا البروتين اللي راح أشوفه حسب الترتيب فاللي
+
+373
+00:36:58,420 --> 00:37:04,360
+بتحكم بترتيب شكل الـ Amino Acids في البروتين هو
+
+374
+00:37:04,360 --> 00:37:10,000
+ترتيب الـ Nucleotides في الـ DNA كل Amino Acid هو
+
+375
+00:37:10,000 --> 00:37:18,240
+نتيجة ثلاثةورا بعض اسمهم Codon من الـ «DNA» أو الـ
+
+376
+00:37:18,240 --> 00:37:24,800
+«RNA» المكافئله بنسميه Reading Frame يعني القطع
+
+377
+00:37:24,800 --> 00:37:29,880
+اللي بنقراها هذه ضرورية تكون مظبوطة تماماً حتى
+
+378
+00:37:29,880 --> 00:37:34,140
+تطلع القراءة سليمة غير هيك راح يطلع إشي مالوش معنى
+
+379
+00:37:34,140 --> 00:37:35,960
+يعني في اسلة
+
+380
+00:37:41,180 --> 00:37:47,200
+الآن هذه مرة ثانية موضوع إنه أنا أحيانًا بكون في
+
+381
+00:37:47,200 --> 00:37:52,840
+عندى Exons اللي هم المنطقة اللي يتم الاستفادة منها
+
+382
+00:37:52,840 --> 00:37:56,480
+و التعامل معها وهي اللي بدنا إياها وفي Introns
+
+383
+00:37:56,480 --> 00:38:03,680
+اللي هم ما لهومش معنى هذولة يعني نظريًا يتم قصهم و
+
+384
+00:38:03,680 --> 00:38:09,820
+التخلص منهم فاحنا نحكي بعد شويةإنه الـ «non»
+
+385
+00:38:09,820 --> 00:38:16,000
+بيسموه يعني «non-coding RNA» ماشي الـ «DNA» لما
+
+386
+00:38:16,000 --> 00:38:21,020
+حكينا «non-coding» كنا نقول يعني بفهمها على مستوين
+
+387
+00:38:21,020 --> 00:38:29,120
+اللي هي إنه ممكن تكون «non-coding» يعني نهائيًا لا
+
+388
+00:38:29,120 --> 00:38:37,570
+يتم نسقه، ماشيالـ L-introns بيتم نسخها بس بيتم
+
+389
+00:38:37,570 --> 00:38:42,610
+الاستغناء عنها بس ممكن قطع من الـ DNA لا يتم نسخها
+
+390
+00:38:42,610 --> 00:38:47,590
+أصلاً مش فيها بداية وإبدأ هون وPromote ال region
+
+391
+00:38:47,590 --> 00:38:51,770
+وأشياء حتى تتحكم فيها ففي أشياء لا يتم نسخها
+
+392
+00:38:51,770 --> 00:38:58,930
+نهائياً فهذا بنعتبره Non-coding الـ DNAوفي الـ RNA
+
+393
+00:38:58,930 --> 00:39:04,610
+اللي راح يطلع بالنسبة للآن كـ Intron هو Non-coding
+
+394
+00:39:04,610 --> 00:39:09,830
+فعلى مستوى الـ RNA الـ Exons، هنا ثلاثة في هذا
+
+395
+00:39:09,830 --> 00:39:17,270
+البروتين الـ Exons هم الـ Coded بحيث أنه يتم
+
+396
+00:39:17,270 --> 00:39:22,010
+استفادة من الـ RNA تبعهم في عمل البروتين والـ
+
+397
+00:39:22,010 --> 00:39:27,810
+Introns هو Non-coding RNA اللي راح يطلع، ماشي؟فهذه
+
+398
+00:39:27,810 --> 00:39:32,750
+درجة من التعقيد ومن الطواهر اللي موجودة و… لما
+
+399
+00:39:32,750 --> 00:39:39,670
+نيجي ندرس أي حالة، أي مرض، أي خلية، أي جزء من جسم
+
+400
+00:39:39,670 --> 00:39:44,670
+الإنسان من ناحية وراثية، فيه سرطان معين، فيه مرض
+
+401
+00:39:44,670 --> 00:39:50,970
+معين، نتعامل مع هذه المفاهيم، ماشي؟ إنهلمّا بدي
+
+402
+00:39:50,970 --> 00:39:55,050
+أصف أنا، وشو اللي موجود عندهم؟ وليش صار المرض؟ وشو
+
+403
+00:39:55,050 --> 00:39:59,130
+الاختلال؟ لأن طبعاً بالأول بدي أفهم كيف الطبيعي
+
+404
+00:39:59,130 --> 00:40:06,570
+وكيف الإنسان الأصلي أموره سالكة وماشي، ماشي، لأن
+
+405
+00:40:06,570 --> 00:40:10,090
+الـ،
+
+406
+00:40:10,090 --> 00:40:18,350
+حسا، الكتابكم دخل في المرحلة هذه ظاهرة مهمة جدا،
+
+407
+00:40:18,350 --> 00:40:27,210
+بتحاول تفسرليش أو كيف نتحكم بالـ Expression تبع
+
+408
+00:40:27,210 --> 00:40:32,030
+الـGene؟ يعني إحنا في جسم الإنسان فيه مليارات
+
+409
+00:40:32,030 --> 00:40:40,290
+الخلايا يعني عدد مهول لما تيجي تأخذ عشرة أو كسام،
+
+410
+00:40:40,290 --> 00:40:46,370
+ستين مرة أو خمسين مرة لما تيجي تضرب التوافق
+
+411
+00:40:46,370 --> 00:40:51,500
+والتوبة دي، إحنا بالملياراتكيف كل خلية بتهتدي؟ شو
+
+412
+00:40:51,500 --> 00:41:00,960
+الجينات اللي هي لازم تعملها؟ لو سألتكم سؤال الجنين
+
+413
+00:41:00,960 --> 00:41:05,960
+كيف بتنفس؟ كيف باخد الأكسجين من الأم؟ في حد بيقدر
+
+414
+00:41:05,960 --> 00:41:11,140
+يفسرلي ليش في الـMachine الطفل أو الجنين باخد
+
+415
+00:41:11,140 --> 00:41:14,980
+أكسجين الأم؟ مين بعرف؟
+
+416
+00:41:20,240 --> 00:41:24,380
+أنا آسف إذا بدي أسمع منكم، يعني يا دكتور أحمد لو
+
+417
+00:41:24,380 --> 00:41:30,940
+في حد بيقدر يجاوب أو يعني في حد عنده معرفة أو
+
+418
+00:41:30,940 --> 00:41:31,520
+اقتراح
+
+419
+00:41:37,230 --> 00:41:41,670
+السؤال يعني انسمع، بس في سؤال برضه من دكتورة بسمة
+
+420
+00:41:41,670 --> 00:41:46,930
+قبل مش عارفه السؤال، بتسأل يعني الـIntron من
+
+421
+00:41:46,930 --> 00:41:50,170
+الـNon-coding RNA يعني هي سؤالها إنه هل هو موجود
+
+422
+00:41:50,170 --> 00:41:53,990
+ولا لأ، مش فاهم السؤال دكتورة بسمة لأ، هي لما نيجي
+
+423
+00:41:53,990 --> 00:42:00,690
+نتفرج بعدين، وين هذا الـIntron، حسب شكله، حسب
+
+424
+00:42:00,690 --> 00:42:07,920
+الرسمة، قطعة RNA انقصت وإنها في النواعهل هي تطلع
+
+425
+00:42:07,920 --> 00:42:14,100
+في الـ Cytoplasm؟ أكيد، أتوقع ذلك، بس أنا اللي
+
+426
+00:42:14,100 --> 00:42:18,160
+بعرفه من دراسات أخرى ومن أشياء أحنا درسناها اللي
+
+427
+00:42:18,160 --> 00:42:23,440
+هو بيسموها الـ Micro RNAs اللي في الـ Serum، يعني
+
+428
+00:42:23,440 --> 00:42:30,020
+حتى برا الخلايا تمامًا، أسه هو شيء موجود، ماشي؟
+
+429
+00:42:30,020 --> 00:42:37,850
+يعني نتيجة تكون الـ Messenger RNAونجاحه وخروجه من
+
+430
+00:42:37,850 --> 00:42:44,290
+النواء أو تكونه في قطع إضافية فأحيانًا كثيرة هذه
+
+431
+00:42:44,290 --> 00:42:48,130
+القطع الإضافية يمكن إلها أدوار، يمكن إلها همية
+
+432
+00:42:48,130 --> 00:42:55,690
+فأنا اللي بحكيه أنا متأكد من أنه هو يُعتبر من
+
+433
+00:42:55,690 --> 00:43:00,270
+الظواهر اللي يتم دراستها في التسبب في بعض الأمراض
+
+434
+00:43:00,270 --> 00:43:08,860
+يعني بقيسه قداش أطوالهاوكمييتها حجم معين كثير قليل
+
+435
+00:43:08,860 --> 00:43:14,660
+وبتوصل إنها موجودة في الـ Serum يعني نسحبها من دم
+
+436
+00:43:14,660 --> 00:43:19,280
+المريض ونفحص عليها اللي هي الـ Micro RNA شغل صعب
+
+437
+00:43:19,280 --> 00:43:25,220
+مش سهل وإن الواحد يقيمها بس هذه الظاهرة هي ظاهرة
+
+438
+00:43:25,220 --> 00:43:32,960
+تحدث، موجودة، شو دورها؟ خلّينا الآن نتفق على مبدأ
+
+439
+00:43:33,380 --> 00:43:42,200
+إنه قد تكون من آليات التحكم في تشغيل الجينات، «ليش
+
+440
+00:43:42,200 --> 00:43:46,000
+هذا الجين بيشتغل؟» «ليش هذا الجين كامل؟» «ليش هذا
+
+441
+00:43:46,000 --> 00:43:50,100
+الجين اشتغل 50%؟» «ليش هذا الجين اشتغل 90%؟» «ليش
+
+442
+00:43:50,100 --> 00:43:55,720
+هذا الجين اشتغل 10%؟» يعني ظواهر زي هيك سؤالك برجع
+
+443
+00:43:55,720 --> 00:44:00,940
+مرة ثانية الآن الإنسان الطبيعي الـHemoglobin اللي
+
+444
+00:44:00,940 --> 00:44:07,520
+في دمه عنديعني في الحياة هو بنسميه Hemoglobin A1
+
+445
+00:44:07,520 --> 00:44:13,000
+وA2 هدولة اللي موجودين، هدولة اللي بيفيدونه الجنين
+
+446
+00:44:13,000 --> 00:44:17,880
+في بطن أمه ما بيفيده يكون عنده من نفس هذا النوع من
+
+447
+00:44:17,880 --> 00:44:24,480
+الـ Hemoglobin فربنا بيجعل في الجنين في مرحلة الـ
+
+448
+00:44:24,480 --> 00:44:27,820
+مرحلة الجنينية التسعة أشهر اللي واحدة في بطن أمه
+
+449
+00:44:28,320 --> 00:44:32,100
+إنه يكون عنده إشي بيقولوله الـS-Hemoglobin F
+
+450
+00:44:32,100 --> 00:44:36,980
+-Hemoglobin، الـS تبع الـSickle Cell فالـF
+
+451
+00:44:36,980 --> 00:44:39,560
+-Hemoglobin اللي بيسموه Fetal Hemoglobin نوعية
+
+452
+00:44:39,560 --> 00:44:43,180
+مختلفة من الـHemoglobin بس هو Hemoglobin، Okay
+
+453
+00:44:43,180 --> 00:44:49,500
+ميزته إن ارتباطه بالـOxygen أقوى فهو بيسحب
+
+454
+00:44:49,500 --> 00:44:56,920
+الـOxygen من الأم فالفكرة إنه أنا في كلنا، مش بس
+
+455
+00:44:56,920 --> 00:45:03,610
+أنا، كلنافي مرحلة الجنينية من حياتنا بحاجة إنه
+
+456
+00:45:03,610 --> 00:45:09,470
+نكوّن Hemoglobin F وليس Hemoglobin A1 وA2 اللي
+
+457
+00:45:09,470 --> 00:45:13,490
+موجود معانا في بعد الحياة فاللي بيصير بس يولد
+
+458
+00:45:13,490 --> 00:45:17,690
+الإنسان ويتغير البيئة اللي هو فيها بيصير الدريقتين
+
+459
+00:45:17,690 --> 00:45:24,170
+تتنفس ويصير يختلف شويه شويه الـHemoglobin بتغير
+
+460
+00:45:24,750 --> 00:45:29,310
+الجسم بيبطل يطلع الـ F- Hemoglobin ويصير يطلع الـ
+
+461
+00:45:29,310 --> 00:45:34,830
+A1 والـ A2 Hemoglobin فهذه ظاهرة كيف ربنا سوّاها
+
+462
+00:45:34,830 --> 00:45:41,230
+فينا، ليش تتحدث؟ هي طبعًا واضحة سببها إنه أنا لو
+
+463
+00:45:41,230 --> 00:45:45,970
+كان عندي نفس القوة تجذب الـ Oxygen زي الـ
+
+464
+00:45:45,970 --> 00:45:50,170
+Hemoglobin تبع الوالد معناته ما راح أخد Oxygen
+
+465
+00:45:50,170 --> 00:45:56,820
+منها، ما راح ينتقل الـ Oxygenففي لحظة معينة الـ
+
+466
+00:45:56,820 --> 00:46:02,220
+Hemoglobin F هذا لازم هو اللي انبنى وبعدين بس
+
+467
+00:46:02,220 --> 00:46:06,540
+نولد، هذا بيوقف، بيصير بيطلع نوع ثاني فهذه الظواهر
+
+468
+00:46:06,540 --> 00:46:13,500
+بتحدث في جسم الإنسان كتير وكل نوع خلايا بتلاقي فيه
+
+469
+00:46:13,500 --> 00:46:18,380
+إشي لازم يتشغل وفيه إشي لازم يتوقف فيه إشي بتشغل،
+
+470
+00:46:18,380 --> 00:46:21,500
+فيه إشي بتوقف شو الأليات اللي بتتحكم في هذا الأمر؟
+
+471
+00:46:21,910 --> 00:46:25,210
+القاليات اللي بتتحكم فيه هي الـ Epigenetic
+
+472
+00:46:25,210 --> 00:46:31,330
+Mechanisms أحنا أساى بطلنا نتكلم شو الـ DNA نفسه
+
+473
+00:46:31,330 --> 00:46:37,350
+عنده شو المعلوم اللي فيه أحنا أساى الـ يعني كل
+
+474
+00:46:37,350 --> 00:46:41,230
+خلايا الجسم راح يكون فيها الـ Hemoglobin F و الـ
+
+475
+00:46:41,230 --> 00:46:48,350
+Hemoglobin S و الـ A1 و A2 كجين آه كلها فيها الجين
+
+476
+00:46:48,350 --> 00:46:55,460
+هذا والجينات هذهبس في مرحلة معينة، في حياة معينة،
+
+477
+00:46:55,460 --> 00:47:01,440
+في ظرف معين بيصير فيه داعي لإيش محدد فبيتم إنتاجه
+
+478
+00:47:01,440 --> 00:47:06,160
+أو بيتم تشغيله أو بيتم، بيقول سويًا لما نقول عن
+
+479
+00:47:06,160 --> 00:47:09,920
+الـDNA بيصير الـTranscription تبعه عشان يعطينا
+
+480
+00:47:09,920 --> 00:47:15,980
+الـMessenger RNA عشان يعطينا الـProtein تبعه حتى
+
+481
+00:47:15,980 --> 00:47:19,740
+تقدر الوظيفة المطلوبة فلما أنا أشوف الـProtein طلع
+
+482
+00:47:20,300 --> 00:47:24,360
+معناته الجين تبعه اشتغل طب ليش اشتغل؟ ليش بعدين
+
+483
+00:47:24,360 --> 00:47:29,460
+وقف؟ هذه دواهر الـ Epigenetics دواهر الـ
+
+484
+00:47:29,460 --> 00:47:37,460
+Epigenetics في جزء منها يعني راح نحكي عن فيه
+
+485
+00:47:37,460 --> 00:47:46,840
+اختلافات وتفاوت بين كمية التعديل الكيماوي على نفس
+
+486
+00:47:46,840 --> 00:47:57,570
+الـDNA أو الـHistonesواللي هي بيعتبروها الـ
+
+487
+00:47:57,570 --> 00:48:02,610
+«هستون» ففي عندي ظاهرة الـ «DNA methylation» يعني
+
+488
+00:48:02,610 --> 00:48:09,870
+الـ «DNA» بعد ما كان شو اسمه؟
+
+489
+00:48:09,870 --> 00:48:16,210
+الـ «DNA» بعد ما كان بطريقته العادية مثلًا أنه في
+
+490
+00:48:16,210 --> 00:48:20,150
+مكان معين بيصير عملية «methylation»أو على الـ
+
+491
+00:48:20,150 --> 00:48:28,290
+Histone ممكن تكون فيها Variations أو Glucosylation
+
+492
+00:48:28,290 --> 00:48:33,010
+أو Methylation كمان للـ Histone أو الـ Histone-T
+
+493
+00:48:33,010 --> 00:48:38,450
+يعني الـ Histone هو القطعة
+
+494
+00:48:38,450 --> 00:48:44,590
+اللي بتملف الـ DNA عليها بشكل أكبر حتى يصغر حجمه
+
+495
+00:48:44,590 --> 00:48:51,260
+حتى نعرف ندخله كله بالكرموزومماشي، إذا ما كانش فيه
+
+496
+00:48:51,260 --> 00:48:59,980
+«هستون» و«كروماتيد» أو الـ… الـ… يعني الأشياء
+
+497
+00:48:59,980 --> 00:49:04,640
+الثانية اللي هي إضافية حتى يتم عملية لف الـDNA ما
+
+498
+00:49:04,640 --> 00:49:09,000
+بيكون بالشكل اللي بيطلع فيه بشكل مضغوط وبعدين يكون
+
+499
+00:49:09,000 --> 00:49:14,140
+هيك مرتب وييجي جانب بعض وينفصلوا عن بعض لو كان فيه
+
+500
+00:49:14,140 --> 00:49:20,060
+اختلال في اللفومش مضغوط بشكل كبير ممكن يخرّب
+
+501
+00:49:20,060 --> 00:49:25,360
+الدنيا إن انفصالها ما يكون انفصال سلس وسهل متكافئ
+
+502
+00:49:25,360 --> 00:49:33,100
+مظبوط زي ما بدنايا واضح؟ في أسئلة؟
+
+503
+00:49:33,100 --> 00:49:38,920
+في أسئلة؟
+
+504
+00:49:38,920 --> 00:49:44,440
+ماشي فالآن
+
+505
+00:49:45,120 --> 00:49:49,960
+الظواهر الـ Epigenetics اللي هي حكينا وتكلمنا عن
+
+506
+00:49:49,960 --> 00:49:57,060
+الـ Micro-RNA أو الـ Non-coding RNA وجوده كيف
+
+507
+00:49:57,060 --> 00:50:05,020
+أدواره، الـ DNA methylation الـ Histone سواء Tail
+
+508
+00:50:05,020 --> 00:50:09,720
+methylation أو Histone variation، هذه كلها ظواهر
+
+509
+00:50:09,720 --> 00:50:17,740
+موجودة وتشتركفي قضية التحكم في عملية قراءة الجينات
+
+510
+00:50:17,740 --> 00:50:22,180
+أنه الجين اللي يشتغل وأنه الجين اللي يظل ساكن فهذه
+
+511
+00:50:22,180 --> 00:50:27,940
+كلها غواهر موجودة وإن شاء الله لما ندخل بعدين في
+
+512
+00:50:27,940 --> 00:50:32,690
+بعض المحاضرات يمكن نضرب أنفل عليهمبس أنا بظن إنه
+
+513
+00:50:32,690 --> 00:50:38,430
+مهم كمبدأ فكري هيكي عقلي الواحد يكون فاهمه ويستوعب
+
+514
+00:50:38,430 --> 00:50:42,030
+لمن يسمع هذه الكلمة شو اللي موجود وشو اللي بتكلم
+
+515
+00:50:42,030 --> 00:50:47,590
+عنه، هاي الـ Methylation فالـ Cytosine ممكن يتحول
+
+516
+00:50:47,590 --> 00:50:53,030
+لـ Methylcytosine وFive-Hydroxymethylcytosine كنوع
+
+517
+00:50:53,030 --> 00:51:03,360
+موجودة الأشياء هذه أحيانًا تتدخل إنهلمّا تم قراءة
+
+518
+00:51:03,360 --> 00:51:12,400
+أو تعامل الـ DNA بتم أحيانًا استخدام هذه التراكيب
+
+519
+00:51:12,400 --> 00:51:17,640
+في إنه كيف يقرأ، كيف، من وين لوين، كيف يقرأ الـ
+
+520
+00:51:17,640 --> 00:51:21,100
+Three-dimensional architecture الـ Dynamic
+
+521
+00:51:21,100 --> 00:51:23,800
+packaging of the genome بيوضع Increasing Level of
+
+522
+00:51:23,800 --> 00:51:28,530
+Resolutionفيه هنا الـ Individual Chromosome
+
+523
+00:51:28,530 --> 00:51:35,710
+Territories يعني في النواة كل كروموزوم هكي لف صارت
+
+524
+00:51:35,710 --> 00:51:40,110
+مش مضغوطة كثير زي ما بنشوفه عند الـ Karyotype في
+
+525
+00:51:40,110 --> 00:51:43,910
+الـ Cell Division بس كل واحد إله زي ما بيقولوا هنا
+
+526
+00:51:43,910 --> 00:51:48,870
+معتبرينه إله منطقة، إله Territoryوبعدين أحيانًا
+
+527
+00:51:48,870 --> 00:51:53,830
+بتفاعلوا مع بعض بس في الأخير لما بدنا نيجي نقرأ
+
+528
+00:51:53,830 --> 00:52:00,890
+إشي بده الـ Promoter Region تبدأ تشتغل ويتم تحفيز
+
+529
+00:52:00,890 --> 00:52:06,010
+القليات نسق الـ DNA أو اللي هو الـ Transcription
+
+530
+00:52:06,010 --> 00:52:09,510
+للـ DNA وأحيانًا، يعني هون الظاهرة اللي بديوا
+
+531
+00:52:09,510 --> 00:52:14,310
+يحكوها أنه أصل أن الـ Promoter Region إحنا نكون
+
+532
+00:52:14,310 --> 00:52:22,110
+قبلالـ Coding Gene Segment مباشرة بس أحيانًا فيه
+
+533
+00:52:22,110 --> 00:52:27,790
+Promoter Areas أو Promoter Regions بتكون أبعد
+
+534
+00:52:27,790 --> 00:52:34,210
+بكتير بس نتيجة الحبل الطويل ممكن يكونوا جنب بعض في
+
+535
+00:52:34,210 --> 00:52:42,210
+لحظة معينة بحيث أن هذا يساعد على أنه قليلة التحكم
+
+536
+00:52:42,210 --> 00:52:47,800
+أنه وين تبدأ في القراءةماشي، من وين أبدأ في الـDNA
+
+537
+00:52:47,800 --> 00:52:55,540
+اللازم؟ فهذه قطع وظواهر بتحدث الآن
+
+538
+00:52:55,540 --> 00:53:03,200
+أنا هذا الموضوع أتوقفنا عنده المرة اللي فاتت ويعني
+
+539
+00:53:03,200 --> 00:53:14,060
+خلّينا نفهمه من خلال أمثلةنفترض أنا بدي أدرس الـ
+
+540
+00:53:14,060 --> 00:53:18,080
+«جين»، في أسئلة؟
+
+541
+00:53:18,080 --> 00:53:22,500
+دكتور أحمد، في إيش أسئلة؟ تقريبًا لحد الآن، لأ
+
+542
+00:53:22,500 --> 00:53:29,560
+طيب، أسسا نفترض أنا بدرس الـ «ABO System Blood
+
+543
+00:53:29,560 --> 00:53:37,800
+Group» فيه قليل، فيه مكان، وإلي أكثر من خيار،
+
+544
+00:53:37,800 --> 00:53:42,840
+ماشي؟أنا الـ Blood Group الـ Inheritance تبعتها
+
+545
+00:53:42,840 --> 00:53:47,440
+الـ ABO System ومفهوم شوهيه واللي ده بندخل فيها
+
+546
+00:53:47,440 --> 00:53:54,000
+تفاصيلة بعدين بيصير بس نفترض إنسان AB شو صار فيه
+
+547
+00:53:54,000 --> 00:53:59,340
+هذا الإنسان؟ لازم يكون أخذ الـA من الأب وأخذ الـB
+
+548
+00:53:59,340 --> 00:54:04,840
+من الأم مثلا أو العكسفالفكرة إنه في عندي Two
+
+549
+00:54:04,840 --> 00:54:09,040
+Chromosomes لهذا القليل الآن اللي هيحكي أنا بهمني
+
+550
+00:54:09,040 --> 00:54:16,020
+في عندي نسختين موجودة من الأب والأم وكل واحد موجود
+
+551
+00:54:16,020 --> 00:54:22,920
+على Chromosome تبعه وكل واحد على مستوى الجين موجود
+
+552
+00:54:22,920 --> 00:54:31,390
+أثناء حالة الـ ABO System نفترض لحالة إنسان ABاللي
+
+553
+00:54:31,390 --> 00:54:35,790
+راح يصير عندى بيسميه فوق Balanced Expression شو
+
+554
+00:54:35,790 --> 00:54:41,370
+يعني؟ يعني لما أنا أجى أحفظه على مستوى البروتين
+
+555
+00:54:41,370 --> 00:54:44,890
+اللي هو الـ enzyme اللي راح يغير الـ H-antigen للـ
+
+556
+00:54:44,890 --> 00:54:49,530
+A B-antigen بحيث إنه أنا بلما ألاقي الـ A والـ B
+
+557
+00:54:49,530 --> 00:54:54,290
+-antigen معناته الـ enzyme موجود والـ enzyme أجى
+
+558
+00:54:54,290 --> 00:55:05,150
+من الـ RNA اللي أجى من الـ DNAلما أنا آجي أشوف كم
+
+559
+00:55:05,150 --> 00:55:09,910
+عنده من هذا النوع ومن هذا النوع من الـ DNA ومن الـ
+
+560
+00:55:09,910 --> 00:55:19,670
+RNA راح ألاقي إن الـ Two copies من المصدرين
+
+561
+00:55:19,670 --> 00:55:29,190
+أثنينهم شغلت، ماشي؟ المثال عندكم هناحطينه إنه أنا
+
+562
+00:55:29,190 --> 00:55:34,830
+بدرس الموضوع تبع إنه الـ «RNA» للي من أبوي في SNP
+
+563
+00:55:34,830 --> 00:55:39,230
+إنه في هذا المكان Single Nucleotide Polymorphism
+
+564
+00:55:39,230 --> 00:55:45,350
+يعني لما قريته كل المتشابهات معادة بس في مكان واحد
+
+565
+00:55:45,350 --> 00:55:53,430
+هذا طلع «G» مش الـ «A» ماشي، فهذه بنسميها «SNP»الـ
+
+566
+00:55:53,430 --> 00:55:58,990
+SNP هذا خلّتني على مستوى الـ RNA أقدر أفرّق بينهم
+
+567
+00:55:58,990 --> 00:56:05,810
+أما وظيفياً كشيء في الوظيفة يمكن أثنينهم بيؤدي
+
+568
+00:56:05,810 --> 00:56:09,490
+لنفس الـ Amino Acid وبالتالي ما في اختلاف بالوظيفة
+
+569
+00:56:09,490 --> 00:56:14,150
+يعني هو مش إنه اختلفوا عن بعض بس هي قالية قراءة
+
+570
+00:56:14,150 --> 00:56:22,070
+وفهم من وين أجت هذه الـ RNAفهنا بالمثال اللي
+
+571
+00:56:22,070 --> 00:56:26,950
+حاطينه الـSnap إنه على المصدر هذا اللي هو ضمن
+
+572
+00:56:26,950 --> 00:56:34,450
+الـApp بيكون إنه فيه الـT هنا وهنا من الـM فيه
+
+573
+00:56:34,450 --> 00:56:41,030
+الـC فالـRNA راح يكون هنا الـG وهنا الـA فلما يكون
+
+574
+00:56:41,030 --> 00:56:45,550
+عندي حالة زي مثلا واحد blood group تبعته AB blood
+
+575
+00:56:45,550 --> 00:56:51,490
+groupفيه Expression Balanced راح يكون معروف الـ A
+
+576
+00:56:51,490 --> 00:57:00,270
+والـ B ونختار أنهم زي بعض، ماشي فهي ظاهرة بتحدث أن
+
+577
+00:57:00,270 --> 00:57:07,950
+أحيانًا في جينات لما نكون عنده Two copies أثنان هم
+
+578
+00:57:07,950 --> 00:57:13,670
+شغالين بما يرضي الله بحيث أنه البروتين الناتج من
+
+579
+00:57:13,670 --> 00:57:20,450
+RNAلقنا بنسبة 50% لهذا النوع و50% من هذا النوع،
+
+580
+00:57:20,450 --> 00:57:27,770
+ماشي؟ الآن ناخد المثال اللي تحت وبدى أنا أركز عليه
+
+581
+00:57:27,770 --> 00:57:33,170
+من ناحية اللي أنه في المناعم اللي هو الـ Light
+
+582
+00:57:33,170 --> 00:57:39,490
+Chain والـ Heavy Chain تبع الـ Immunoglobulin الـ
+
+583
+00:57:39,490 --> 00:57:44,310
+Immunoglobulin مثلا الـ Light Chain نعرف فيه Kappa
+
+584
+00:57:44,310 --> 00:57:52,820
+وLambdaوالـ Lambda والـ Kappa مني عندي نوعين واحد
+
+585
+00:57:52,820 --> 00:57:57,340
+من أبوي وواحد من أمي والـ Lambda عندي برضه نوعين
+
+586
+00:57:57,340 --> 00:58:04,360
+واحد من أبوي وواحد من أمي فبالنسبة للـ Light Chain
+
+587
+00:58:04,360 --> 00:58:12,600
+Gene في عندي أربع copies هذولة أربع copies موجودة
+
+588
+00:58:12,600 --> 00:58:18,350
+في كل خلايا الجسموفي الجينات، في الـDNA، على
+
+589
+00:58:18,350 --> 00:58:24,830
+الـChromosome أظن Chromosome 22، وهناكم موجودين،
+
+590
+00:58:24,830 --> 00:58:32,430
+ماشي، الشيء اسمه، الأربعة موجودين، Chromosomes
+
+591
+00:58:32,430 --> 00:58:39,910
+222، فعندي أربعة نصفين، في أي خلية في الجسم، يعني
+
+592
+00:58:39,910 --> 00:58:42,770
+أنا بمسك الـB-Lymphocytes المسؤولات عن
+
+593
+00:58:42,770 --> 00:58:47,530
+الـImmunoglobulinsوباجي بدرسهم في اختلافات بينهم
+
+594
+00:58:47,530 --> 00:58:53,530
+إنه كل واحد منهم من الأربع نسخ من الجينات واحدة
+
+595
+00:58:53,530 --> 00:58:58,850
+بتكون شغالة يعني أنا باجي هنا أدرس الـ Protein
+
+596
+00:58:58,850 --> 00:59:04,050
+الناتج وله جاي من الـ RNA فأنا درست الـ RNA الناتج
+
+597
+00:59:04,050 --> 00:59:10,490
+بلاقي هذا كله إيه فاللي صار إنه في هذه الخلية
+
+598
+00:59:10,490 --> 00:59:13,310
+تحديداً
+
+599
+00:59:14,280 --> 00:59:17,840
+هذه النسقة هي اللي شغالة وهذه النسقة تمامًا مش
+
+600
+00:59:17,840 --> 00:59:25,560
+شغالة واضح؟ فهذه أحيانًا ظاهرة بتحدث بنسميها الـ
+
+601
+00:59:25,560 --> 00:59:30,240
+Monoallelic Expression أو بالـ دائمًا بيقولونها
+
+602
+00:59:30,240 --> 00:59:35,220
+Allelic Exclusion يعني إنه إذا اشتغل واحد بيمنع
+
+603
+00:59:35,220 --> 00:59:39,260
+الثاني يشتغل فهدولة
+
+604
+00:59:39,260 --> 00:59:45,400
+زي ما تقول Two Extremes يا إما50%، 50%، 50%، 50%،
+
+605
+00:59:45,400 --> 00:59:45,760
+50%، 50%، 50%، 50%، 50%، 50%، 50%، 50%، 50%، 50%،
+
+606
+00:59:45,760 --> 00:59:55,880
+50%، 50%، 50%، 50%، 50%، 50%، 50%، 50%، 50%، 50%،
+
+607
+00:59:55,880 --> 01:00:00,760
+50%، 50%، 50%، 50%، 50%، 50%، 50%، 50%، 50%، 50%،
+
+608
+01:00:00,760 --> 01:00:01,600
+50%، 50%، 50%، 50%، 50%، 50%، 50%، 50%، 50%، 50%،
+
+609
+01:00:01,600 --> 01:00:03,980
+50%، 50%، 50%، 50%، 50%، 50%، 50%، 50%، 50%، 50%،
+
+610
+01:00:03,980 --> 01:00:08,320
+50%، 50%، 50%، 50%، 50%، 50%، 50%، 50%، 50%،
+
+611
+01:00:08,320 --> 01:00:09,560
+50%، 50%، 50%، 50%، 50%، 50%، 50%، 50%، 50%، 50%،
+
+612
+01:00:09,560 --> 01:00:20,660
+50%، 50%فهنا أنا استخدمت آلية الـ Snip ولقيت بمحض
+
+613
+01:00:20,660 --> 01:00:25,980
+الصدفة حظ الواحد يكويس إنه فيه Snip معين واضح
+
+614
+01:00:25,980 --> 01:00:31,200
+بيفرقلي إن هذا جاي من وين وهذا جاي من وين إذا لقيت
+
+615
+01:00:31,200 --> 01:00:38,100
+إشي وبقدر أقيم قداش شغل كل قليل من الـGene هذا
+
+616
+01:00:38,100 --> 01:00:39,700
+واضحة
+
+617
+01:00:43,240 --> 01:00:47,380
+في أسئلة؟ في سؤال، يا دكتور، على الـ «سلايد»
+
+618
+01:00:47,380 --> 01:00:51,160
+السابق الموضوع الـ Subchromosomal domains اللي
+
+619
+01:00:51,160 --> 01:00:56,100
+موجود في اللي هو الصورة «A» بتسأل، بتسأل الدكتورة
+
+620
+01:00:56,100 --> 01:00:57,860
+أيش الفرق بين الـ «Chromosome» والـ
+
+621
+01:00:57,860 --> 01:01:00,080
+«Subchromosomal domains» أو الـ «Chromosomal
+
+622
+01:01:00,080 --> 01:01:02,580
+domains» أه الـ «Subchromosomal domains» والـ
+
+623
+01:01:02,580 --> 01:01:07,280
+«Chromosome» أيش الفرق بينهم؟ لأ، لأ، الحين الـ
+
+624
+01:01:07,280 --> 01:01:12,160
+«Chromosomes» أنت بتشوفها في حالة الـ «Karyotype»
+
+625
+01:01:13,720 --> 01:01:19,700
+اللي هو الشكل المضغوط تمامًا اللي بنستفيد أو
+
+626
+01:01:19,700 --> 01:01:26,580
+بحاجته لما الخلية تنقسم، هي عند الانقسام، ماشي؟
+
+627
+01:01:26,580 --> 01:01:30,860
+حتى الـ «DNA» يشتغل والـ «Chromosome» والـ
+
+628
+01:01:30,860 --> 01:01:37,800
+«Werabi» تشتغل، بس لازم الـ «DNA» ما يكون بهذا
+
+629
+01:01:37,800 --> 01:01:43,960
+الشكل المضغوط، لازم يفك، فاهم عليك؟فلما تقول إنه
+
+630
+01:01:43,960 --> 01:01:50,940
+Fact اللي راح يصير إنه في الـ Nucleus كل كروموزوم
+
+631
+01:01:50,940 --> 01:01:58,380
+كأنه ماخذ حيز ماشي أحيانًا في مساعدة بين بعض
+
+632
+01:01:58,380 --> 01:02:04,220
+المساعدة المطلوبة إن أحيانًا الـ Promoter Region
+
+633
+01:02:04,220 --> 01:02:11,100
+هو قطعة بشكل على الـ Primary Structure أو علىالـ
+
+634
+01:02:11,100 --> 01:02:17,020
+«لو» على الحبل أو الخير تبع الـ «DNA» هي منطقة
+
+635
+01:02:17,020 --> 01:02:26,680
+بعيدة فلازم يصير ال .. وين أنت بتحكي الـ domain؟
+
+636
+01:02:26,680 --> 01:02:31,260
+شوف تحت، شو اللي بتحكي أنت عنها؟ في في الصورة أو
+
+637
+01:02:31,260 --> 01:02:36,160
+في التعليق على الصورة BASF بيقول إن الـ «Chromatin
+
+638
+01:02:36,160 --> 01:02:40,240
+Organized Enlarged Subchromosomaldomain within
+
+639
+01:02:40,240 --> 01:02:44,840
+each territory with loops ده طبعاً بيكمل، بيفصل
+
+640
+01:02:44,840 --> 01:02:48,440
+إيش ال interaction بس، فبتسأل إيش الفرق ما بين
+
+641
+01:02:48,440 --> 01:02:51,720
+الـsubchromosome الدمين اللي بيحكي عنها أنا و
+
+642
+01:02:51,720 --> 01:02:56,880
+الـchromosome، يعني حتة … لأ، لأ، إسمعلي، إسمعلي،
+
+643
+01:02:56,880 --> 01:03:04,200
+الـchromosome هو الخير لفة حبل، ماشي؟ أنت لما تروح
+
+644
+01:03:04,200 --> 01:03:09,310
+تشتريها مثلا من عند البقالة، كيف تشتري الحبل؟بدو
+
+645
+01:03:09,310 --> 01:03:15,990
+يعطيك إياه ملفوف ومربوط وكذا، صح؟ صح؟ تمام لما
+
+646
+01:03:15,990 --> 01:03:23,450
+تيجي بدك تستخدمه فعليًا، ماشي؟ بدك تفكه، صح؟ صحيح
+
+647
+01:03:23,450 --> 01:03:29,710
+الفك والربط من خلال الترتيب هذا بس في داخل النواء
+
+648
+01:03:29,710 --> 01:03:35,590
+كل كروموزوم زي كأنه ماخذ جهة حتى هيك ياخد راحته
+
+649
+01:03:35,590 --> 01:03:41,150
+إنه يفكه، ماشي؟ صحيحبهذه الناحية، حسناً، في ملاحظة
+
+650
+01:03:41,150 --> 01:03:47,010
+ثانية حتى أي قطع الجين على مستوى الجين حسناً،
+
+651
+01:03:47,010 --> 01:03:52,070
+الـChromosome الواحد فيه ألف جين، صح؟ صحيح الجين
+
+652
+01:03:52,070 --> 01:03:57,130
+الواحد، حتى يشتغل، لازم يكون فيه تهيئة من منطقة
+
+653
+01:03:57,130 --> 01:04:03,150
+قبله إنه فيه Promoter Region، في منطقة بدها يعني
+
+654
+01:04:03,150 --> 01:04:08,210
+تهيئ أنه آه والله، ابدأ أقرأ من هنااللي هي الـ
+
+655
+01:04:08,210 --> 01:04:14,550
+Starton Codon للبداية فالـ Promoter Regions
+
+656
+01:04:14,550 --> 01:04:20,950
+أحيانًا قد تكون إيش اللي هي الجزء المباشر وأحيانًا
+
+657
+01:04:20,950 --> 01:04:26,150
+بتكون منطقة بعيدة وأحيانًا زي ما حاطين هنا من لسه
+
+658
+01:04:26,150 --> 01:04:32,750
+فتعة ثانية يعني يعني زي ما هم حاطين هنا أنه «high»
+
+659
+01:04:32,750 --> 01:04:39,610
+و «high» يعني فيه كروموزومالجين ويكون الـ Promoter
+
+660
+01:04:39,610 --> 01:04:46,390
+Region تبعه باتحاج لقطع ثاني من خيط ثاني موجود
+
+661
+01:04:46,390 --> 01:04:50,250
+جنبه، بس لازم يكون جنبه بحيث أنه يقدر يتفاعل معاه،
+
+662
+01:04:50,250 --> 01:04:53,050
+حتى لو هو بعيد عن بعض، واضحة؟
+
+663
+01:04:56,080 --> 01:05:00,280
+تمام، يعني دكتورة أتمنى يكون سؤال وضح يعني دكتورة
+
+664
+01:05:00,280 --> 01:05:04,200
+أسماء، هو يعني اللي المقصود غالبًا الحيث اللي
+
+665
+01:05:04,200 --> 01:05:07,940
+بيحتلوا الكرموزوم من النواء بشكل رئيسي، هو السبق
+
+666
+01:05:07,940 --> 01:05:10,940
+كرموزوم الدولي أفضل، لما نكون في النواء، لازم يكون
+
+667
+01:05:10,940 --> 01:05:16,800
+مفكوك زيادة صحيح ممكن تشتغل عليه وانت لفه لف شديد،
+
+668
+01:05:16,800 --> 01:05:22,490
+ممكنش تقرا منه إيش، لازم تفكه هيك شويةولمّا بدك
+
+669
+01:05:22,490 --> 01:05:26,690
+تصل للمنطقة اللي بدك إياها ضروري كتير كتير لسه بدك
+
+670
+01:05:26,690 --> 01:05:34,750
+تفكها أكثر، واضح؟ إن شاء الله فالآن يعني إحنا اللي
+
+671
+01:05:34,750 --> 01:05:41,150
+بدنا نحكي إنه من الظواهر اللي كمان الموجودة إنه
+
+672
+01:05:41,150 --> 01:05:53,840
+أحيانًا الـ… الـ… الـExpression تبعالـ DNA يعني
+
+673
+01:05:53,840 --> 01:05:57,460
+الـ expression للـ DNA للجين يعني قضية شو اللي
+
+674
+01:05:57,460 --> 01:06:02,800
+يقرأ، ماشي؟ وليش أي خلية فيها الجين اللي فلاني
+
+675
+01:06:02,800 --> 01:06:09,260
+يقرأ سواء نتيجة يعني من الـ chromosome اللي من
+
+676
+01:06:09,260 --> 01:06:12,720
+الأب ولا من الأم، يعني هذه اللي هي الـ Allelic
+
+677
+01:06:12,720 --> 01:06:17,600
+imbalance، يعني أهمية أنهأحيانًا يعني نفترض أنا
+
+678
+01:06:17,600 --> 01:06:25,340
+عندي Two copies أبوي مريض عنده مرض معين مثلًا
+
+679
+01:06:25,340 --> 01:06:30,220
+Female patient والدها أخذت Two X-Chromosomes واحد
+
+680
+01:06:30,220 --> 01:06:34,180
+من الأم وواحد من الأب افرض الأب عنده مرض
+
+681
+01:06:34,180 --> 01:06:41,120
+Hemophilia هل الـHemophilia هي عندها واحد شغال من
+
+682
+01:06:41,120 --> 01:06:46,530
+الأم، صح؟بس هل دايماً فقط الأم اللي يشغالي ومافيش
+
+683
+01:06:46,530 --> 01:06:50,890
+إشي من الأب ولا شو دخله ولا كده فلما يكون عندي
+
+684
+01:06:50,890 --> 01:06:56,510
+ظواهر يعني أنا هنا بحكي اللي هي الـ Unbalanced
+
+685
+01:06:56,510 --> 01:07:01,790
+Expression يعني اللي هي إحنا نفترض زي الـ ABO
+
+686
+01:07:01,790 --> 01:07:05,010
+System إن أثنين راح يشتغلوا و أثنين راح يجيبوا
+
+687
+01:07:05,010 --> 01:07:08,650
+خمسين بالمية من اللازم ويعطونا الأشي الكمية اللي
+
+688
+01:07:08,650 --> 01:07:13,300
+أنا بديها زي الـ ABO Systemفهذه اللي بيكون فيها
+
+689
+01:07:13,300 --> 01:07:18,500
+الـ Allelic Balance نسميه بيكون اثنينها مشغلة الـ
+
+690
+01:07:18,500 --> 01:07:23,700
+Unbalanced Expression هو نحطين إنه حوالي من خمس
+
+691
+01:07:23,700 --> 01:07:27,080
+إلى عشرين بالمئة من الـ Autosomal Genes يعني هي
+
+692
+01:07:27,080 --> 01:07:33,540
+ظاهرة بتحدث في نسبة قليلة من الـ Autosomal Genes،
+
+693
+01:07:33,540 --> 01:07:38,680
+ناشي؟ فالـ ليش؟
+
+694
+01:07:40,360 --> 01:07:47,580
+هنا يعني بالأخير Epigenetic Changes يعني ظواهر
+
+695
+01:07:47,580 --> 01:07:51,580
+معينة يمكن درجة الـ methylation لهذه الأشياء غير
+
+696
+01:07:51,580 --> 01:07:54,740
+درجة الـ methylation لهذا الـ يعني الـ copy من
+
+697
+01:07:54,740 --> 01:07:58,580
+الأب غير الـ copy من الأم في درجة الـ methylation
+
+698
+01:07:58,580 --> 01:08:05,160
+مثلاً فخلت واحدة تقدر تكون أنجحة مثلاً وهذه يعني
+
+699
+01:08:05,160 --> 01:08:11,470
+نسبة قليلة من الجينات بتتثثر بهذه الظاهرةوالـ يعني
+
+700
+01:08:11,470 --> 01:08:21,650
+في الغالب هذه في المرحلة الأولى من الحياة النواحي
+
+701
+01:08:21,650 --> 01:08:27,850
+الثانية الأمثل الثانية حاطينا أربعة أنه أربعة
+
+702
+01:08:27,850 --> 01:08:32,250
+بيكونوا واحدة من الـ Two copies هي الشغالة
+
+703
+01:08:32,250 --> 01:08:38,530
+والثانية نهائيا مش شغالة، ماشي؟فهي اللي بيسموها
+
+704
+01:08:38,530 --> 01:08:42,210
+«monoallelic expression» حكينا قبل شوية على
+
+705
+01:08:42,210 --> 01:08:45,550
+الخلايا المنعم الـ «T» والـ «B» الـ «Lymphocytes»
+
+706
+01:08:45,550 --> 01:08:48,590
+للـ «Amminoglobulin» الـ «heavy and light chains»
+
+707
+01:08:48,590 --> 01:08:51,410
+وللـ «Alpha» و«Beta» الـ «Chains» تبعات الـ «T
+
+708
+01:08:51,410 --> 01:08:57,350
+Cell» فهدولة في «Somatic Rearrangement» يعني
+
+709
+01:08:57,350 --> 01:09:06,220
+بطريقة ما حتى تصير مكوّنإمكانية إنه يكون عندنا
+
+710
+01:09:06,220 --> 01:09:11,380
+Antibodies ومناعة تهاجم أي إشي في الحياة، أي إشي
+
+711
+01:09:11,380 --> 01:09:17,100
+في الكون، أي إشي ممكن نتعرض إليه، يعني الـTCR
+
+712
+01:09:17,100 --> 01:09:20,340
+والـImmunoglobulin نتكلم عن عشر أو أس أحداشر لعشر
+
+713
+01:09:20,340 --> 01:09:25,260
+أو أس تمانتاش، Antibodies، Variable Region فلما
+
+714
+01:09:25,260 --> 01:09:31,360
+تكون هذه الشغلة تمت، بصير قص ولسق في الـDNA اللي
+
+715
+01:09:31,360 --> 01:09:37,390
+يسمونه Somatic Rearrangementفهذه الظاهرة يعني
+
+716
+01:09:37,390 --> 01:09:43,450
+مكلفة جداً وأنا مثلاً للـ B-Lymphocytes للـ
+
+717
+01:09:43,450 --> 01:09:46,790
+Immunoglobulins بكون عندي Two copies واحد على
+
+718
+01:09:46,790 --> 01:09:51,930
+كروموزوم 14 من أبوي واحد على كروموزوم تبع أمي
+
+719
+01:09:51,930 --> 01:09:56,930
+بيكون في أي خلية B-Lymphocytes واحد شغلت مايكونوش
+
+720
+01:09:56,930 --> 01:10:01,170
+اثنين شغلت في نفس الخلية في خلاية بتشغل هذا ال
+
+721
+01:10:01,170 --> 01:10:05,700
+copy في خلاية مشغلة ال copy التانيةبالنسبة للـ
+
+722
+01:10:05,700 --> 01:10:10,520
+Light Chain، في عندى أربع نسخ برضه واحد من الأربع
+
+723
+01:10:10,520 --> 01:10:15,000
+هي اللي شغلها الـ ثلاث الثانيات، يا إما مجربات، يا
+
+724
+01:10:15,000 --> 01:10:20,260
+إما مش مجربات بس بالأخير أي De-Lymphocyte ناجحة
+
+725
+01:10:20,260 --> 01:10:25,880
+يكون فيها one copy لـ الـ one قليل هو اللي بس شغال
+
+726
+01:10:25,880 --> 01:10:31,820
+الثاني ساكن، مافيش إله expression فهي ظاهرة موجودة
+
+727
+01:10:31,820 --> 01:10:36,610
+وظاهرة مهمةوبيسموها من خلال الـ Somatic
+
+728
+01:10:36,610 --> 01:10:40,830
+Rearrangement وهي ظاهرة يعني متأكدة منها وسهلة
+
+729
+01:10:40,830 --> 01:10:47,410
+ومفهومة يعني فيه كانوا يقولولنا وإحنا طلاب على من
+
+730
+01:10:47,410 --> 01:10:52,530
+زمان على X-chromosome in inactivation يعني بالنسبة
+
+731
+01:10:52,530 --> 01:11:00,330
+بالذات للـFemales لما أنا آجي أدرس الـ … لما أنا
+
+732
+01:11:00,330 --> 01:11:07,400
+آجي أدرسكيف أنه الـ X-Chromosome اللي بيشتغل راح
+
+733
+01:11:07,400 --> 01:11:12,420
+نلاقي إنه كل خلاياها راح ينقسموا يا إما خلية
+
+734
+01:11:12,420 --> 01:11:17,220
+بتشتغل على الـ Chromosome مثلا X تبع الأب أو الـ
+
+735
+01:11:17,220 --> 01:11:22,980
+Chromosome تبع الأم وهذه بالـ Early Empyrogenesis
+
+736
+01:11:22,980 --> 01:11:27,600
+ماشي، ظاهرة بتحدث، بالتالت إذا مثلا في كوبي فيها
+
+737
+01:11:27,600 --> 01:11:32,590
+مرض وفي كوبي مافيش فيها مرض، ماشي؟على مستوى
+
+738
+01:11:32,590 --> 01:11:38,250
+الجزيئي على مستوى الـ «بيو كيميكل» على مستوى أدرس
+
+739
+01:11:38,250 --> 01:11:43,830
+الـ «RNA» والبروتين الموجود في الخلية هذه بيلاقيه
+
+740
+01:11:43,830 --> 01:11:49,530
+كله من مصدر واحد مش من المصدرين في نفس الخلية فهذه
+
+741
+01:11:49,530 --> 01:11:53,950
+بدنا نسميها «mono-allelic expression» فهي ظاهرة
+
+742
+01:11:53,950 --> 01:12:00,990
+بتحدث اللي حاطينا هنا أنت هذه الأصل أنت هيك موجود
+
+743
+01:12:02,360 --> 01:12:07,820
+وشكلها ظاهرة بتحدث لـ… يعني فيه لها Ex
+
+744
+01:12:07,820 --> 01:12:16,240
+-inactivation center حاطينه هنا فالخلية
+
+745
+01:12:16,240 --> 01:12:24,380
+في الـ Early Epidermogenesis في بداية تخلق الخلايا
+
+746
+01:12:24,380 --> 01:12:28,660
+في جسم الإنسان في المرحلة الأولى لما عدد الخلايا
+
+747
+01:12:29,240 --> 01:12:39,040
+120، 40، كذا، بتم انقسامها أو بتم ملاحظة إنه بس
+
+748
+01:12:39,040 --> 01:12:42,200
+نصها واحدة من الـ X-Chromosome شغال والثاني
+
+749
+01:12:42,200 --> 01:12:46,960
+بيعطينا اسمه Bar Body بكون هكذا، Condensed
+
+750
+01:12:46,960 --> 01:12:55,960
+وUnactivated فالـ … هنا مثلا، هذا تبع الأب الشغال
+
+751
+01:12:55,960 --> 01:13:00,350
+وهذا تبع الأم اللي كان نايمالخلية التانية جنبها،
+
+752
+01:13:00,350 --> 01:13:06,190
+لأ، تبع الأم هو اللي شغال وتبع الأب أو بالعكس اللي
+
+753
+01:13:06,190 --> 01:13:12,010
+ناعم فـ Serial and clonal maintenance of that gene
+
+754
+01:13:12,010 --> 01:13:24,250
+هذا يعني بيعطينا تفسير تخيل أنه أنا بفترض لو إنسان
+
+755
+01:13:24,250 --> 01:13:31,060
+عنده two copiesللـ X-Chromosome عليهم مرض معين
+
+756
+01:13:31,060 --> 01:13:37,300
+الأصل إذا كان الـChromosome الواحد شفال، شفال كويس
+
+757
+01:13:37,300 --> 01:13:42,680
+وبيعطينا الاشي المطلوب أن هذه المرأة مش بس إنها
+
+758
+01:13:42,680 --> 01:13:46,940
+حامل حامل، ممكن تنقل إلى أطفالها، بس الأصل مايكون
+
+759
+01:13:46,940 --> 01:13:50,800
+عندها مرض بس لو لقينا درجة بسيطة من المرض، شو
+
+760
+01:13:50,800 --> 01:13:56,200
+معناته؟معناته إنه صار في جزء من الخلايا في جسمها
+
+761
+01:13:56,200 --> 01:14:01,560
+فعلاً حامل لو بتعرض الجين أو بتعرض البروتين أو
+
+762
+01:14:01,560 --> 01:14:07,400
+بتعرض الإشي اللي عامل المشكلة وبالتالي فبتكون
+
+763
+01:14:07,400 --> 01:14:12,320
+عندها نسبة من المرض أخف مش مقارنة زي الذكر اللي
+
+764
+01:14:12,320 --> 01:14:16,020
+بيكون بس «1X» وده disease بيكون Catastrophic يعني
+
+765
+01:14:16,020 --> 01:14:20,500
+إشي قوي كثير بس مابتكونش Normal زي الإنسان العادي
+
+766
+01:14:22,650 --> 01:14:28,970
+فهدولة ضاهرتين سهلات Random Allelic Silencing أو
+
+767
+01:14:28,970 --> 01:14:33,610
+Activation أو Genomic Imprinting بالأخير، هدولة
+
+768
+01:14:33,610 --> 01:14:37,570
+Epigenetic Details
+
+769
+01:14:37,570 --> 01:14:43,290
+أنا والله يعني، بالذات على هدولة الطواهر يعني مش
+
+770
+01:14:45,390 --> 01:14:50,470
+يعني مش aware الآن على شو الحالة، شو المرض شو
+
+771
+01:14:50,470 --> 01:14:56,830
+الأشي اللي بحكوا عنه بس يعني بالأخير يعني الرسالة
+
+772
+01:14:56,830 --> 01:15:05,070
+اللي بدنا إياها أنه أنا عندي أكتر أحيانًا one pair
+
+773
+01:15:05,070 --> 01:15:11,190
+أحيانًا أكتر من نفس الـGene وحتى لو عندي أكتر من
+
+774
+01:15:11,190 --> 01:15:19,810
+pair هناكلسة كمان درجة من التعقيد في إنه كمية الـ
+
+775
+01:15:19,810 --> 01:15:26,850
+Transcription إنه شو درجة الشغل لو كان، يعني هسة
+
+776
+01:15:26,850 --> 01:15:30,830
+صحيح فيه جينات معينة في خلايا معينة، بدك إيه؟ Red
+
+777
+01:15:30,830 --> 01:15:34,370
+blood cell بدها الـ Hemoglobin مثلاً الـ
+
+778
+01:15:34,370 --> 01:15:36,530
+Immunoglobin أو الـ B-Lymphocyte بدها الـ
+
+779
+01:15:36,530 --> 01:15:40,230
+Immunoglobin جين يشتغل بس، طب أنا عندي أكتر من
+
+780
+01:15:40,230 --> 01:15:45,600
+خيار، شو بشتغل؟عندى Two copies بيشتغلوا تماما زى
+
+781
+01:15:45,600 --> 01:15:52,080
+بعض أحيانا نعم بس في خمس لعشرين بالمية من الـ
+
+782
+01:15:52,080 --> 01:15:58,080
+Autosomal Genes بيصير Unbalanced ممكن توصل إنه
+
+783
+01:15:58,080 --> 01:16:02,480
+Monoallelic Expression إنه 100% من مصدر المصدر
+
+784
+01:16:02,480 --> 01:16:09,910
+التاني المائل ودخل وممكن يكوننسب أقل متفاوتة ما
+
+785
+01:16:09,910 --> 01:16:13,950
+بين خمسين بالمية وخمسين بالمية ومية بالمية وصفر
+
+786
+01:16:13,950 --> 01:16:19,750
+فكل الظواهر اللي بتتكلم عنها هي بنسميها Epigenetic
+
+787
+01:16:19,750 --> 01:16:27,050
+Influences Epigenetic Control ماشي والسبب من ليش
+
+788
+01:16:27,050 --> 01:16:31,030
+بنسميه Epigenetic مش Genetic لأنه الـGene نفسه
+
+789
+01:16:31,030 --> 01:16:34,290
+الـGene ما تغيرش الـGene هو اللي بدي يعطينا
+
+790
+01:16:34,290 --> 01:16:39,950
+البروتين هذا لسهبينهم ما فيش هالفرق، يعني ما كانش
+
+791
+01:16:39,950 --> 01:16:45,790
+فيه فرق ناتج عن الجين نفسه، في أسئلة؟ دكتور، في
+
+792
+01:16:45,790 --> 01:16:52,050
+سؤال، بس أخير من الدكتورة، أعتقد، بخصوص الـClonal
+
+793
+01:16:52,050 --> 01:16:56,270
+Maintenance بعد ما يصير عملية الـClonal
+
+794
+01:16:56,270 --> 01:17:02,010
+Maintenance معناته أنه إذا بدت بشكل معين، بتكمل
+
+795
+01:17:02,010 --> 01:17:07,750
+بهذا الشكل، ماشي؟يعني بيصير جوا جسم الإنسان
+
+796
+01:17:07,750 --> 01:17:14,190
+مجموعتين من الخلايا بالنسبة لهذا الـGene، ماشي؟
+
+797
+01:17:14,190 --> 01:17:20,750
+يعني نخترض Chromosome معين أو الـX-Chromosome
+
+798
+01:17:20,750 --> 01:17:27,070
+مثلا، اللي حطينا عليه قبل شوية الآن،
+
+799
+01:17:27,070 --> 01:17:32,590
+إما هعمل مثلا نقول بالـG6PD Deficiencyماشي، فيه
+
+800
+01:17:32,590 --> 01:17:38,530
+الـG6PD الـ… الـEnzyme هذا فيه على الـX-Chromosome
+
+801
+01:17:38,530 --> 01:17:49,310
+وفيه مرض فس… الـ… الـ… الـ… الـ… لما نتكلم عن شو
+
+802
+01:17:49,310 --> 01:17:57,530
+اسمه؟ الـ… الـ… الخلايا تبعت الـ… الـ… اللي بظن
+
+803
+01:17:57,530 --> 01:18:05,840
+الواحد إذا كانبديت إنسان ذكر وقعدت أفحص في الـ
+
+804
+01:18:05,840 --> 01:18:12,380
+«expression» تبع هذا الـ «جين»، ماشي؟ بلاقي إن كل
+
+805
+01:18:12,380 --> 01:18:17,940
+خلايا مش قادرة تعمل الـ «بروتين» اللي أنا بديها،
+
+806
+01:18:17,940 --> 01:18:23,700
+بس في مرحلة مبكرة في حياة الأنثى، بكون أنا عندي
+
+807
+01:18:23,700 --> 01:18:28,540
+two copies، بس مايصير أثنينهم يشتغلوا أحيانًابتكون
+
+808
+01:18:28,540 --> 01:18:33,500
+إنه لهذا لغرض الجين معين لسبب معين لشغل معينة
+
+809
+01:18:33,500 --> 01:18:39,380
+بتلاقي بس نسخة واحدة اشتغلت ففي مرحلة معينة يمكن
+
+810
+01:18:39,380 --> 01:18:45,340
+يكون مش 100%، 50%، 50% خلايا شغلت هذا الجين وخلايا
+
+811
+01:18:45,340 --> 01:18:50,540
+شغلت هذا الجين يمكن مثلا 20%، 80% إشي شغل هذا
+
+812
+01:18:50,540 --> 01:18:57,760
+الجين و80% شغل الجين التاني الـ20% بيظلوا 20%كل ما
+
+813
+01:18:57,760 --> 01:19:04,640
+بنقسمه بيظلهم نفسهم من ناحية تشغيلهم لأي نسخة من
+
+814
+01:19:04,640 --> 01:19:10,420
+الـ X-Chromosome والمجموعة الثانية بتظل تشغل نفس
+
+815
+01:19:10,420 --> 01:19:18,000
+الـG يعني هذه خاصية تظل تورث في الخلايا الناتجة عن
+
+816
+01:19:18,000 --> 01:19:22,960
+انقسام الخلية اللي ظهرت فيها هذه الناحية، واضح؟
+
+817
+01:19:25,080 --> 01:19:29,560
+طبعًا، دكتور، بس ثاني من الـ أو النقطة يعني الحابب
+
+818
+01:19:29,560 --> 01:19:32,900
+الكريم أنه اتوضح أنه عمره يخد الـ chromosomal
+
+819
+01:19:32,900 --> 01:19:36,980
+domain اللي حكينا عنه قبل شوية فيه مكان للنقطة دي
+
+820
+01:19:36,980 --> 01:19:42,880
+يعني ما لها ال chromosomal domain؟ بده تعيد بس
+
+821
+01:19:42,880 --> 01:19:47,340
+النقطة يعني أو الشرح إلها يعني إيش هي أو تطلع يعني
+
+822
+01:19:47,340 --> 01:19:52,040
+يعني، يعني ما تأخدوش المواضيع كثيرة، ماشي، احنا
+
+823
+01:19:52,040 --> 01:19:57,490
+بهمناالشيء بالذات إذا إله تطبيق سريري إذا إله
+
+824
+01:19:57,490 --> 01:20:09,290
+أهمية حتى أقدر أنسخ وأعمل Transcription لـDNA بدي
+
+825
+01:20:09,290 --> 01:20:16,410
+حبل الغسيل، حبل سلك الغسيل يكون المفروض إذا ملفوف
+
+826
+01:20:16,410 --> 01:20:21,860
+كثير كثير كثير ماعرفش أستخدمه، واضح؟ف… صحيح و أنا
+
+827
+01:20:21,860 --> 01:20:24,700
+دكتور برضه يعني بركز على هذه النقطة يعني قضية انه
+
+828
+01:20:24,700 --> 01:20:30,040
+يعني ما تسألوش عن أشياء يعني عشان ما تسيريش مطلوب
+
+829
+01:20:30,040 --> 01:20:33,440
+منكوا يعني قضية الدكتور معتز برضه بيسأل عن الـ
+
+830
+01:20:33,440 --> 01:20:38,000
+«خدها ببساطة» «خدها ببساطة» يعني الدكتور معتز برضه
+
+831
+01:20:38,000 --> 01:20:41,360
+بيسأل عن «Genomic Imprinting» الدكتور طب يعني ما
+
+832
+01:20:41,360 --> 01:20:45,280
+عرش حاجاته لو فرقته أنا بقولك هي نوع من الـ يعني
+
+833
+01:20:45,280 --> 01:20:49,380
+نوع من الـ Epigenetic Mechanisms بس في ملاحظة يعني
+
+834
+01:20:49,380 --> 01:20:55,440
+بدكم تفهموا شغلتالكتاب هذا مع أنه ممتاز و up to
+
+835
+01:20:55,440 --> 01:21:02,020
+date ومهم وكويس، بس مش قرآن، مش حقيقة مطلقة، مش
+
+836
+01:21:02,020 --> 01:21:09,160
+إشي يعني يمكن بعد نسختين من الكتاب يشيلوها كلها
+
+837
+01:21:09,900 --> 01:21:14,180
+يعني الـ Genetic Imprinting هذه إذا بدي أدخل فيها
+
+838
+01:21:14,180 --> 01:21:22,140
+يعني هي تفسير، هي ملاحظة بتعرفوا يعني كلمة نظرية،
+
+839
+01:21:22,140 --> 01:21:26,680
+شو يعني نظرية؟ نظرية هي تفسير قابل إن يكون صح أو
+
+840
+01:21:26,680 --> 01:21:32,410
+خطأما في شيء مطلب، هيك أنه بس لما نحكي عن يعني
+
+841
+01:21:32,410 --> 01:21:37,510
+ظاهرة بتحدث وأنا بفسرها بشكل معين أنا بحاول أنه أو
+
+842
+01:21:37,510 --> 01:21:44,130
+أنا بتدعي والواحد بده يدعي هيك أنه هذا هو التفسير
+
+843
+01:21:44,130 --> 01:21:50,270
+الحقيقي لأنه الظاهرة الإفلانية حدثت بس ممكن بعدين
+
+844
+01:21:50,270 --> 01:21:53,950
+نكتشف أنه الكلام هذا غلط وبعدين يعني يطلع أنه
+
+845
+01:21:53,950 --> 01:21:58,700
+مالوش قيمة كتير، هاي من ناحيةوالناحية الثانية اللي
+
+846
+01:21:58,700 --> 01:22:05,700
+هي أنه يعني حسب الأدوات اللي عندها حسب الإمكانات
+
+847
+01:22:05,700 --> 01:22:09,220
+اللي عندها يعني أنا لما نصير عندي إمكانات أكثر
+
+848
+01:22:09,220 --> 01:22:15,400
+وأدق بقول بقدر أسويها فالـ Imprinting صراحة يعني
+
+849
+01:22:15,400 --> 01:22:20,480
+فيه ظاهرة بقراها الـ Epigenetics معقدة الـ
+
+850
+01:22:20,480 --> 01:22:24,140
+Epigenetics كلها، Mechanisms، كيف بتتم، وشو هي
+
+851
+01:22:25,580 --> 01:22:33,600
+بدّعي إنه للآن ما حدا عنده أدوات انعدل الـ
+
+852
+01:22:33,600 --> 01:22:41,640
+Epigenetics ماشي، فهي ظواهر هيك تظن هيك النظرية
+
+853
+01:22:41,640 --> 01:22:50,080
+العالية المقبولة اللي هي يعني إنها يعني التفسير
+
+854
+01:22:50,080 --> 01:22:55,950
+الأقرب للصحة نعتبره بهذا الشكلبس يعني أنا
+
+855
+01:22:55,950 --> 01:23:01,070
+مافهمتهاش كثير مش كده، قولتلكم أنا ماعنديش أمثلة
+
+856
+01:23:01,070 --> 01:23:05,910
+يعني اللي هي تفسرها زي مثلا بالنسبة للـ B-cells
+
+857
+01:23:05,910 --> 01:23:09,530
+والـ Immunoglobulin الـGenes وكيف بتعامل الجسم
+
+858
+01:23:09,530 --> 01:23:13,170
+معاهم وكيف اختلافات الـ B-Lymphocytes وكيف كده
+
+859
+01:23:13,170 --> 01:23:17,690
+وكيف كده فهي بتعتمد على إنك يكون عندك آلات أو
+
+860
+01:23:17,690 --> 01:23:23,310
+أدوات وتكون تدور على إشي معين وتستفيد منهبس هي
+
+861
+01:23:23,310 --> 01:23:30,110
+نظريات بقولك فيه إشي زي هيك ماشي فيه
+
+862
+01:23:30,110 --> 01:23:36,070
+يعني هيك بتدخلونا بإشي يعني ممكن نطول ومش راح
+
+863
+01:23:36,070 --> 01:23:40,390
+أعتبره داخل لأنه أنا مش متأكد منه فيه بيقولك ليش
+
+864
+01:23:40,390 --> 01:23:45,930
+براءة الرحم وليش الإمرأة المطلقة و لا الإمرأة
+
+865
+01:23:45,930 --> 01:23:51,620
+المات عند زوجها الأرماليلازم تمتنع كدا عن الزواج
+
+866
+01:23:51,620 --> 01:24:02,480
+لأنه فيه يعني فيه أختام، فيه تأثيرات في جسم المرأة
+
+867
+01:24:02,480 --> 01:24:09,200
+من زوجها، ماشي وأحيانًا هذه الشغلات بتتم توريثها
+
+868
+01:24:09,200 --> 01:24:15,210
+يعني، ده بتتذكروا، يعني هي إشي بعرفهالـMHC
+
+869
+01:24:15,210 --> 01:24:18,710
+Molecules، الـAntibodies اللي كنا نستخدمهم عشان
+
+870
+01:24:18,710 --> 01:24:23,090
+نعرف شو الـType تبع الـHLA، الـTyping وكذا من
+
+871
+01:24:23,090 --> 01:24:29,290
+النساء، اتزوجوا رجال كثيرين يعني بتلاقيها عندها
+
+872
+01:24:29,290 --> 01:24:34,930
+دمها فيه Antibodies بشكل معين يعني فإنها تترك بصمة
+
+873
+01:24:34,930 --> 01:24:38,210
+Imprinting يعني البصمة الوراثية، هو أنا بدنا
+
+874
+01:24:38,210 --> 01:24:43,270
+نسميها أيه كده أسس أنا بفهمهاخلّينا هيك ناخدها
+
+875
+01:24:43,270 --> 01:24:53,390
+البساطة إنه عبارة عن قالية للتحكم أنه copy من الـ
+
+876
+01:24:53,390 --> 01:25:00,130
+DNA اللي بتتم تشغيله الجسم والخلايا متنوعة جداً
+
+877
+01:25:00,130 --> 01:25:05,170
+فيه خلايا كلها تشتغل الـ two couples زي بعض
+
+878
+01:25:05,170 --> 01:25:11,350
+وشغالين اثنين مع اختلافهم عن بعض بنسبة 50% و50%
+
+879
+01:25:12,280 --> 01:25:15,640
+والمثال اللي حطيناه على مستوى إنك درسته على مستوى
+
+880
+01:25:15,640 --> 01:25:19,560
+الـ RNA لسه مش على مستوى البروتين يمكن البروتين
+
+881
+01:25:19,560 --> 01:25:22,760
+يطلع إنه مافيش فرق بينهم على الـ SNP اللي
+
+882
+01:25:22,760 --> 01:25:29,780
+حطوناياهم أما الأمثل الثاني عبارة عن فيه تفاوت إنه
+
+883
+01:25:29,780 --> 01:25:36,760
+النسختين من الـ DNA لا يتم قراءتهم بشكل متساوي،
+
+884
+01:25:36,760 --> 01:25:41,390
+واضحة؟عشان برضه يا دكتور بعد أذنك يعني عشان يعني
+
+885
+01:25:41,390 --> 01:25:48,130
+كنقطة أخيرة يعنييعني ثبتها .. يعني الـ chapter زي
+
+886
+01:25:48,130 --> 01:25:52,050
+ما حكت تسأل يعني هدير يعني ال chapter فيه معلومات
+
+887
+01:25:52,050 --> 01:25:55,450
+كبيرة وكثيرة ومليان معلومات يعني فيه كتير معلومات
+
+888
+01:25:55,450 --> 01:25:59,890
+ممكن الدكتور ما اتطرق إلها فإنتوا ما ت .. يعني
+
+889
+01:25:59,890 --> 01:26:03,410
+تسددوش على حالك و ترجعوا تسألوا عنها وخلاص يعني
+
+890
+01:26:03,410 --> 01:26:06,850
+طالما الدكتور ما ركز عليها فالتركيز عليها مش هيكون
+
+891
+01:26:06,850 --> 01:26:11,910
+بالقدر اللي الدكتور شاهو يعني صحيح .. صحيحالمراجع
+
+892
+01:26:11,910 --> 01:26:18,310
+اللي زي هيك أنا بقول يعني، يعني إذا الواحد عنده
+
+893
+01:26:18,310 --> 01:26:22,830
+اهتمام بمرض معين، بحالة معينة، بده يفهم جانب معين،
+
+894
+01:26:22,830 --> 01:26:28,550
+مش غلط، يكون طبعاً يعني في عزد الـNet والإنترنت
+
+895
+01:26:28,550 --> 01:26:34,330
+والـGoogle وكذا، ممكن الأمور اختلفت، بس عيب
+
+896
+01:26:34,330 --> 01:26:39,040
+المصادر التانية في المعلوماتاللي هي قضية إن
+
+897
+01:26:39,040 --> 01:26:44,660
+أحيانًا مش موثقة الـ «نت» يمكن تقع في مصدر يعتبر
+
+898
+01:26:44,660 --> 01:26:51,640
+ضعيف، يعتبر بالأخير أي معلومة ممكن تكون عبارة عن
+
+899
+01:26:51,640 --> 01:26:59,740
+نسميها رأي شخص معين يعني، مش عارف عليا؟ مش بقصين
+
+900
+01:26:59,740 --> 01:27:08,860
+حقيقة فالآن لما نقر هذا الكتاب ماشيأنا باعتبر إذا
+
+901
+01:27:08,860 --> 01:27:13,400
+الواحد بدي يدرس طب ويكون عنده خصوصا يعني أنا مقدر
+
+902
+01:27:13,400 --> 01:27:17,660
+أنه عندكم امتحانات تانية ومواد تانية ومواضيع تانية
+
+903
+01:27:17,660 --> 01:27:25,610
+مطلوبة منكم أنهالواحد بدي يوخد زي ما تقول يركز في
+
+904
+01:27:25,610 --> 01:27:31,690
+ذهنه على إنه يستوعب المفاهيم ويستوعب المفاهيم بقدر
+
+905
+01:27:31,690 --> 01:27:38,430
+المستطاع من خلال أمثلة تقرّب له الفهم وتكون يعني
+
+906
+01:27:38,430 --> 01:27:44,450
+فيه إلها يعني شيء هو شافه يعني أنا والله، آه والله
+
+907
+01:27:44,450 --> 01:27:47,960
+شوفت ثلاثيميا أو شوفت «Skills of Anemia»شايف Down
+
+908
+01:27:47,960 --> 01:27:51,760
+Syndrome شايف ناس عندهم Cancer الأشياء اللي أنت
+
+909
+01:27:51,760 --> 01:27:56,980
+بتشوفها لما تكون إشي بتكون بتشوفه إنك تفهم بدقة
+
+910
+01:27:56,980 --> 01:28:01,500
+ليش هذا الأمر حدث، هذا ضروري جداً فلما يكون حد
+
+911
+01:28:01,500 --> 01:28:06,120
+بيشرحلك التفصيل زيادة يا ريت يكون عندي مرجع أقدر
+
+912
+01:28:06,120 --> 01:28:12,460
+أرجعله عشان أقرأ عن هذه الحالة أما كالآن مفاهيم
+
+913
+01:28:12,980 --> 01:28:19,740
+بالذات إن نتكلم عن المناع، عن الوراثة، المفاهيم
+
+914
+01:28:19,740 --> 01:28:26,460
+يعني، بدل واحد لما نتكلم على شو يعني الـStructure
+
+915
+01:28:26,460 --> 01:28:30,980
+of the DNA، فيه كروموزوم، المقول كروموزوم موجود،
+
+916
+01:28:30,980 --> 01:28:35,820
+سواء يعني الحبل هذا لفته ولا فرته، ما هو حبل،
+
+917
+01:28:35,820 --> 01:28:40,740
+بالأخير حبل، ماشي؟ في حالة الـCell Division، بديها
+
+918
+01:28:40,740 --> 01:28:45,130
+مضغوط كتير،في حالة اللي لما بدي أشتغل عليها، بدي
+
+919
+01:28:45,130 --> 01:28:51,730
+أفكه لما أنا أفكه، مرات بفكه نصف فكة عشان يعني
+
+920
+01:28:51,730 --> 01:28:56,890
+بكون فيها مجال وقتها إنه فيه promoter regions في
+
+921
+01:28:56,890 --> 01:29:00,870
+بعض الـ«بروموتر ريجن» قبل الجين تماماً وفيه
+
+922
+01:29:00,870 --> 01:29:05,290
+promoter regions ممكن تكون بعيد عنه بما فيها بعيد
+
+923
+01:29:05,290 --> 01:29:09,870
+عنه حتى لو على كرموزوم ثاني بس لأنه كل واحد إله
+
+924
+01:29:09,870 --> 01:29:15,930
+مكانهماشي هيك باحتفظ فيه الأمور بالنسبة للإسلاك
+
+925
+01:29:15,930 --> 01:29:19,850
+هذه والإحبال هذه ماشي حاجة بتقدر الوظيف المطلوب
+
+926
+01:29:19,850 --> 01:29:25,030
+يعني خليها بشكل مبسط ولمّا أنتوا تقرأوا من الكتاب
+
+927
+01:29:25,030 --> 01:29:32,570
+تطلعوا الصور اقرأوا الجداول اقرأوا المربعات
+
+928
+01:29:32,570 --> 01:29:36,550
+هيك اللي حاطط فيها إشي اقرأوا المقدمة واقرأوا
+
+929
+01:29:36,550 --> 01:29:44,010
+الختاميعني دايماً إذا بيحطلك إشي هو بيكون بديك
+
+930
+01:29:44,010 --> 01:29:48,230
+تفهم مقهوم معين، هذا اللي بيهمناه، ماشي؟ الـToo
+
+931
+01:29:48,230 --> 01:29:54,150
+much details مش مطلوبة، ماشي؟ ومش شطارة يعني، ومش
+
+932
+01:29:54,150 --> 01:30:02,350
+بالذات إذا شغل يعني يمكن مش متفق عليها، ماشي؟طبعا
+
+933
+01:30:02,350 --> 01:30:05,170
+نستغل وجودك يا دكتور برضه في نقطة تانية يعني أنه
+
+934
+01:30:05,170 --> 01:30:09,790
+الـ «جدول» اللي بعتناله للطلاب صحيح إنه فيه يعني
+
+935
+01:30:09,790 --> 01:30:12,670
+هذا الكلام بوجهه للطلاب يعني صحيح إنه فيه 18
+
+936
+01:30:12,670 --> 01:30:16,490
+chapter موجودين لكن طبيعي مش هيفتم شرح الـ18
+
+937
+01:30:16,490 --> 01:30:19,810
+chapter بالتفصيل يعني الدكتور وصللي صورة ويعني
+
+938
+01:30:19,810 --> 01:30:24,650
+أتمنى أن أؤكدها كمان أجيتهاإن الشباتر الأخيرة لن
+
+939
+01:30:24,650 --> 01:30:27,770
+تتم تأخذ الأمراض فيها بالتفاصيل، لأن هذه كلها
+
+940
+01:30:27,770 --> 01:30:31,530
+أمراض سريرية التفاصيل
+
+941
+01:30:31,530 --> 01:30:36,970
+السريرية طبعا ما هذه كل حياتك بدك تتعلم عليها، وهي
+
+942
+01:30:36,970 --> 01:30:41,750
+لمرحلة لاحقة بالظبط الأمراض السريرية ما بدنا ندخل
+
+943
+01:30:41,750 --> 01:30:45,880
+تفاصيلهايعني أن تمنتاشر شابتر صحيح عدد لكن في
+
+944
+01:30:45,880 --> 01:30:48,820
+المضمون هيكون على عدد الأسابيع اللي موجودة اللي هي
+
+945
+01:30:48,820 --> 01:30:53,140
+14 أو 13 أسبوع بالظبط يعني مش هنأخد تمنتاشر شابتر
+
+946
+01:30:53,140 --> 01:30:59,240
+بالتفصيل يعني المفهوم بترسخ من خلال المثال صحيح
+
+947
+01:30:59,240 --> 01:31:04,820
+مثال إذا أنت فاهم كمرضإنه في حالة اسمها كدا، بيجي
+
+948
+01:31:04,820 --> 01:31:08,460
+المريض عنده هيك لاحظنا عليه هيك، ليش بيكون هيك
+
+949
+01:31:08,460 --> 01:31:13,520
+فإنت هنا بتسيب يعني ممكن حتى طبعاً يمكن الآن على
+
+950
+01:31:13,520 --> 01:31:19,660
+مستوى طالب طب ثاني ثاني ثالث بدايته يمكن يعني
+
+951
+01:31:19,660 --> 01:31:24,360
+معلومات كتير وتفاصيل كتيرة بس إحنا بناخذها أنا
+
+952
+01:31:24,360 --> 01:31:30,430
+بهمني الأمثلة اللي بتوضح المفهومفاهم عليك كيف؟
+
+953
+01:31:30,430 --> 01:31:34,230
+يعني لما تقولّي «A.B.O System» كلكم بتعرفوا كيف
+
+954
+01:31:34,230 --> 01:31:37,330
+الـGenetics تبعته ومين الـDominant ومين
+
+955
+01:31:37,330 --> 01:31:40,670
+الـRecessive
+
+956
+01:31:40,670 --> 01:31:45,050
+وكيف بكون وكيف كذا وكيف كذا فيعني هذه الأشياء أنا
+
+957
+01:31:45,050 --> 01:31:50,190
+بهمن المفاهيم والمفاهيم يتم شرحها في شكل مبسط من
+
+958
+01:31:50,190 --> 01:31:55,450
+خلال أمثلة فإذا في مثال يعني بالذات بيبين مفهوم
+
+959
+01:31:55,450 --> 01:32:01,560
+معينكويس والواحد هيك ياخده بشكل مبسط نعش ناخد
+
+960
+01:32:01,560 --> 01:32:06,840
+بالتفاصيل الدقيقة وإن كان يعني إذا الواحد يعني هسا
+
+961
+01:32:06,840 --> 01:32:11,480
+سمع الـ يعني هسا الـ band اللي فلاني في الـ
+
+962
+01:32:11,480 --> 01:32:14,700
+chromosome اللي فلاني أنت بتتخيل وين هي، شو هي،
+
+963
+01:32:14,700 --> 01:32:19,820
+ماشي ولمّا نتلاقى ال segment فيها كده من gene كيف
+
+964
+01:32:19,820 --> 01:32:24,460
+ترتيبها وكم intron وكم exon وكده يعني لما أنا أقول
+
+965
+01:32:24,460 --> 01:32:28,670
+والله الـFFM، FMFالجين اللي هو الـ Pyrene الـ
+
+966
+01:32:28,670 --> 01:32:34,250
+«إجزون» رقم 2 ورقم 10 هم اللي فيهم بليمارفزم اللي
+
+967
+01:32:34,250 --> 01:32:38,690
+هي حوالي 200 نوع بليمارفزم وإذا كان double يعني
+
+968
+01:32:38,690 --> 01:32:42,950
+double heterozygous أو homozygous هي اللي بتكون
+
+969
+01:32:42,950 --> 01:32:48,930
+شديدة وكذا وكذا يعني بتعطيك تصور بساعدك في فهم
+
+970
+01:32:48,930 --> 01:32:53,230
+المرض بساعدك في قراءة المعلومات إذا قريتها من مجلة
+
+971
+01:32:53,230 --> 01:33:01,560
+أو من محلطبعًا إن شاء الله إن شاء الله خير أنا إن
+
+972
+01:33:01,560 --> 01:33:07,000
+شاء الله يعني اليوم الـ chapter التالت جاي مش طويل
+
+973
+01:33:07,000 --> 01:33:13,700
+كتير فلينا إذا في حد عنده أسئلة في group الـ
+
+974
+01:33:13,700 --> 01:33:19,910
+WhatsAppبرضه بيحط الواحد إذا بده أسئلة اسأله أنا
+
+975
+01:33:19,910 --> 01:33:24,090
+مبسوط اليوم إنه إذا في أسئلة وحتى نشرح ببطء مش
+
+976
+01:33:24,090 --> 01:33:28,690
+حريص على إنه أخلص كل شيء يعني يمكن في فصول نقدر
+
+977
+01:33:28,690 --> 01:33:34,250
+نشير إليها إشارة بسيطة عادرة بقدر ما إنه في أشياء
+
+978
+01:33:34,250 --> 01:33:39,970
+مفاهيم أهم يعنيو بممكنكوا تجمعوا الأسئلة سواء يعني
+
+979
+01:33:39,970 --> 01:33:43,250
+خلال المحاضرات أو في بداية أي محاضرة، يعني الدكتور
+
+980
+01:33:43,250 --> 01:33:46,650
+بيترك فرصة لكوا تسألوا سواء بالصوت، سواء بالنص
+
+981
+01:33:46,650 --> 01:33:50,590
+كتابة، زي ما بتحبوا بتسألوا في بداية كل محاضرة أو
+
+982
+01:33:50,590 --> 01:33:54,370
+في نص المحاضرة، يعني الأمر متروك لكوا بكل الحرية
+
+983
+01:33:54,370 --> 01:33:57,970
+إن شاء الله الله يعطيكم العافية، و الله يرضى
+
+984
+01:33:57,970 --> 01:34:01,780
+عليكم، و نشوفكم على خير بعد دكرةسامحنا على الغلب
+
+985
+01:34:01,780 --> 01:34:03,580
+يا دكتور، يعطينا الفعالية لا، لا، ليس غلب، أنا
+
+986
+01:34:03,580 --> 01:34:09,760
+والله أتشرف أني أشترك معاكم، و الله يوفقكم، يعطينا
+
+987
+01:34:09,760 --> 01:34:11,880
+الفعالية وإحنا والله أكثر زادنا الشرف يا دكتور،
+
+988
+01:34:11,880 --> 01:34:15,160
+والله يكفي الله يحيط، الله يحيط، يلا السلام عليكم
+
+989
+01:34:15,160 --> 01:34:15,960
+في رعاية الله
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/KblmxBN0mak.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/KblmxBN0mak.srt
new file mode 100644
index 0000000000000000000000000000000000000000..44a7bc67b8afdb73d758c008c9651d69f9081294
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/KblmxBN0mak.srt
@@ -0,0 +1,2210 @@
+1
+00:00:00,930 --> 00:00:08,650
+خلّيني عشان أعمل share فيه
+
+2
+00:00:08,650 --> 00:00:15,430
+ابتداءً، فيه أسئلة من المحاضرة
+
+3
+00:00:15,430 --> 00:00:25,890
+السابقة؟ حد عنده أي ملاحظات، يعني
+
+4
+00:00:25,890 --> 00:00:37,990
+إحنا في المحاضرة اللي فاتت، بدأنا نحكي عن الأمثلة
+
+5
+00:00:37,990 --> 00:00:45,770
+الأقوى والأشد من أنواع الأمراض الوراثية، وبكون إنه
+
+6
+00:00:45,770 --> 00:00:53,310
+قطعة كروموزوم كاملة أو جزء منها، قطعة كبيرة، بتم إن
+
+7
+00:00:53,310 --> 00:00:59,150
+يكون فيها خلل، سواء… وعرفنا إنه ممكن تحدث، ممكن
+
+8
+00:00:59,150 --> 00:01:05,870
+تتكرر، تتزداد، تتقل، تتغير، كذا، وإنه بدأنا نحكي عن
+
+9
+00:01:05,870 --> 00:01:13,970
+الأمثلة على هذا الموضوع. في حد عنده أسئلة؟ أهم
+
+10
+00:01:13,970 --> 00:01:19,950
+ميكانزم، اللي هو Abnormal Chromosomal Segregation،
+
+11
+00:01:19,950 --> 00:01:23,950
+اللي هي قضية الـ Non-Disjunction، يعني إنه لما كان
+
+12
+00:01:23,950 --> 00:01:28,190
+الكروموزومين جانب بعض، لما ييجي في الـ Metaphase، في
+
+13
+00:01:28,190 --> 00:01:35,570
+قضية الـ Cell Division، ينفصلوا لنصين متساويين، بتكون
+
+14
+00:01:35,570 --> 00:01:40,270
+الانقسام بشكل غير متساوي، فالجهة بتكون فيها زيادة،
+
+15
+00:01:40,270 --> 00:01:45,990
+وجهة بتكون فيها نقصان. فهذا الـ… يعني هذه الظاهرة
+
+16
+00:01:48,480 --> 00:01:55,320
+يعني بالذات إذا حدثت، وكانت فقط موجودة، وبحيث إنه
+
+17
+00:01:55,320 --> 00:02:02,880
+بيقولوا إنه كمية الـ DNA متوازنة في الشخص، راح يكون
+
+18
+00:02:02,880 --> 00:02:07,800
+في الغالب ما إلها مشكلة عنده، بقدر ما إنه في ذريته
+
+19
+00:02:07,800 --> 00:02:12,720
+في الـ gametes تبعه، لما تحتاج هذه الخلايا تنقسم،
+
+20
+00:02:12,720 --> 00:02:18,770
+برضه راح يصير فيها مشكلة. وتكلمنا عن Trisomy 21، اللي
+
+21
+00:02:18,770 --> 00:02:24,390
+هو الـ Down Syndrome، وحكينا ارتباطه بكبر عمر الأم
+
+22
+00:02:24,390 --> 00:02:30,470
+بالذات، وكيف أحيانًا أنه بيكون عبارة عن… حتى لما أجي
+
+23
+00:02:30,470 --> 00:02:38,230
+أعده كـ Trisomy 21، بلاقي لأ مافيش نسخة زايدة، إنما
+
+24
+00:02:38,230 --> 00:02:45,340
+نسخة زايدة شابكة على كروموزوم 14، فهي Translocation
+
+25
+00:02:45,340 --> 00:02:48,420
+من
+
+26
+00:02:48,420 --> 00:02:54,540
+الأمثلة على جزء
+
+27
+00:02:54,540 --> 00:03:01,220
+من الـ DNA، اللي هي موضوع الـ DiGeorge Syndrome.
+
+28
+00:03:01,730 --> 00:03:07,230
+بالنسبة للـ DiGeorge Syndrome، خلينا نفرجيكم
+
+29
+00:03:07,230 --> 00:03:19,430
+الصورة هذه. DiGeorge Syndrome images.
+
+30
+00:03:19,430 --> 00:03:25,370
+هذه
+
+31
+00:03:25,370 --> 00:03:28,410
+Save images.
+
+32
+00:03:48,020 --> 00:03:55,700
+الـ DiGeorge Syndrome، الـ
+
+33
+00:03:55,700 --> 00:03:59,900
+DiGeorge
+
+34
+00:03:59,900 --> 00:04:09,180
+Syndrome، هو عبارة عن… الكروموزوم برضه 22، اللي هو
+
+35
+00:04:09,180 --> 00:04:19,760
+يعني الـ Chromosome 22 segment 11.2، عبارة عن قطعة
+
+36
+00:04:19,760 --> 00:04:29,790
+بتكون فيها اختلال. فالـ DiGeorge Syndrome، حكينا نتيجة
+
+37
+00:04:29,790 --> 00:04:35,290
+اختلال هذه
+
+38
+00:04:35,290 --> 00:04:38,910
+القطعة، بيصير خلل في الـ third و fourth pharyngeal
+
+39
+00:04:38,910 --> 00:04:44,470
+pouches تبعات الـ embryogenesis، اللي هم المرحلة
+
+40
+00:04:44,470 --> 00:04:50,230
+الجنينية في خلق الإنسان، اللي هي محل ما كأنه قطعة
+
+41
+00:04:50,230 --> 00:04:53,690
+اللبان مأكولة، هيك الإنسان بيكون في مرحلة معينة.
+
+42
+00:04:54,160 --> 00:04:56,340
+الثالثة والرابعة، هي الـ pouches الفرنجية التي
+
+43
+00:04:56,340 --> 00:05:04,620
+تعطينا الـ Thymus، وفيها تتم التطور والتكوين والـ T
+
+44
+00:05:04,620 --> 00:05:10,040
+-cells، والمناعة الخلوية المتخصصة. فبالتالي بيصير
+
+45
+00:05:10,040 --> 00:05:14,020
+عندنا نقصان مناعة، بيكون عندنا congenital heart
+
+46
+00:05:14,020 --> 00:05:17,840
+disease، وبيكون عندنا hyperparathyroidism،
+
+47
+00:05:17,840 --> 00:05:20,960
+hypoparathyroidism، و hypocalcemia، لأن الـ
+
+48
+00:05:20,960 --> 00:05:25,140
+parathyroid glands بتطلع من الـ
+
+49
+00:05:25,140 --> 00:05:28,320
+third والـ fourth pharyngeal pouches، فما بيكون عندهم
+
+50
+00:05:28,320 --> 00:05:35,880
+بالأخير، الصورة هذه هي لطفل عنده هذه الـ DiGeorge
+
+51
+00:05:35,880 --> 00:05:42,280
+Syndrome. أولًا، الأذنين كما تشاهدون، نزلت لأسفل،
+
+52
+00:05:42,280 --> 00:05:49,500
+فبيسموها low-set ears، و Increased Philtrum، اللي هو
+
+53
+00:05:49,500 --> 00:05:57,500
+المسافة ما بين طرف الأنف وطرف الشفة، بتلاقيها مسافة
+
+54
+00:05:57,500 --> 00:06:02,980
+طويلة. وبيسموها Increased Philtrum، وهي من المظاهر
+
+55
+00:06:02,980 --> 00:06:10,890
+اللي هي… للـ DiGeorge Syndrome. ممكن الواحد لما نيجي
+
+56
+00:06:10,890 --> 00:06:17,730
+ندور عليهم، ده مش كروموزوم كامل، باخد اللي بيسموه
+
+57
+00:06:17,730 --> 00:06:23,870
+Microarray، أو باخد الـ FISH، اللي هو Fluorescence
+
+58
+00:06:23,870 --> 00:06:30,390
+in situ Hybridization. يعني باخد الواحد عبارة عن
+
+59
+00:06:30,390 --> 00:06:40,160
+آلية حتى يدور عليها. في الأمراض الأخرى، ما
+
+60
+00:06:40,160 --> 00:06:44,080
+بدنا شيها، بعدين
+
+61
+00:06:44,080 --> 00:06:49,900
+بدنا ندخل على sex chromosomes، وحكينا في الـ X والـ
+
+62
+00:06:49,900 --> 00:06:58,580
+Y chromosomes، التعقيد بمظهر الإنسان الجنسي، كذكر أو
+
+63
+00:06:58,580 --> 00:07:08,350
+أنثى، بيتم من خلال ثلاث مراحل. المرحلة الأولى، حكينا
+
+64
+00:07:08,350 --> 00:07:13,450
+عنها، هي الـ Chromosomes، وما هي الجينات اللي عندها،
+
+65
+00:07:13,450 --> 00:07:21,130
+ومسؤول عن التحكم في أشياء معينة. الجينات هذه والـ
+
+66
+00:07:21,130 --> 00:07:26,750
+Chromosomes، الـ X والـ Y، بتأثر على الأعضاء
+
+67
+00:07:26,750 --> 00:07:33,770
+التناسلية، الـ Testicles والـ Ovaries، وبتأثر عليها
+
+68
+00:07:33,770 --> 00:07:39,330
+في تطورها، بيأثر عليها في وظيفتها، بيأثر عليها في
+
+69
+00:07:39,330 --> 00:07:45,050
+قضية إفرازها للـ Hormones، ونشاطها بشكل اللازم
+
+70
+00:07:45,050 --> 00:07:50,310
+والطبيعي، بحيث إنه بالأخير بيعطينا المظهر الخارجي
+
+71
+00:07:50,310 --> 00:07:57,070
+لرجل أو امرأة، ذكر أو أنثى، بهذا الشكل. المرحلة
+
+72
+00:07:57,070 --> 00:08:04,710
+الثانية، مهمة في تطور الجنس للإنسان، قضية البيئة
+
+73
+00:08:04,710 --> 00:08:10,970
+اللي هو موجود فيها، يعني قضية التربية، قضية
+
+74
+00:08:10,970 --> 00:08:14,130
+التعليم،
+
+75
+00:08:14,130 --> 00:08:19,180
+على سلوك معين. دائماً بيقولوا، يعني ولد صغير، بتلاقيه
+
+76
+00:08:19,180 --> 00:08:25,360
+وقع، بعيط، بيقولوا إيه؟ بتعيط؟ أنت زلمة، كيف بتعيط؟
+
+77
+00:08:25,360 --> 00:08:29,820
+ما يصيرش تعيط؟ كده يعني، بتلاقيه بأثر عليه بشكل
+
+78
+00:08:29,820 --> 00:08:37,460
+بيخليه يتصرف بشكل معين. فبالنسبة للتطور الجنسي،
+
+79
+00:08:37,460 --> 00:08:45,020
+بالنسبة للـ X و Y كروموزومات، هذه ناحية مهمة جداً. الـ
+
+80
+00:08:45,020 --> 00:08:48,780
+Y-Chromosome، بشكل عام، مافيش فيه عدد كبير من
+
+81
+00:08:48,780 --> 00:08:57,800
+الجينات، يعني قطعة صغيرة، وبتلاقي فيها يعني عدد قليل
+
+82
+00:08:57,800 --> 00:09:02,780
+من الـ… من الجينات، وحجمه صغير.
+
+83
+00:09:06,840 --> 00:09:12,960
+التراكيب الجنسية عند الإنسان في الـ Embryogenesis،
+
+84
+00:09:12,960 --> 00:09:20,860
+بتمر بفترة بيكون عند الإنسان التراكيب مشتركة، وبيكون
+
+85
+00:09:20,860 --> 00:09:26,520
+التراكيب ذكرية وأنثوية. ففي مرحلة، Mesonephric duct،
+
+86
+00:09:26,520 --> 00:09:33,840
+و Müllerian duct، و الـ Ambiguous أو Ambipotent
+
+87
+00:09:33,840 --> 00:09:41,860
+Gonade، يعني هذه غدة، أو مبيض، مستعدة تكون أي نوع،
+
+88
+00:09:41,860 --> 00:09:48,200
+وبتكون جاهزة أن تتوجه هيك أو تتوجه هيك. فهنا
+
+89
+00:09:48,200 --> 00:09:54,320
+التراكيب الجنسية الداخلية، مرتبطة بالتراكيب الجنسية
+
+90
+00:09:54,320 --> 00:10:03,040
+الخارجية. أهم عامل حتى يتم التوجيه باتجاه أن يكون
+
+91
+00:10:03,040 --> 00:10:10,080
+هناك ذكر، هو وجود الـ Y-Chromosome، وعدم وجوده يجعل
+
+92
+00:10:10,080 --> 00:10:15,980
+الأجهزة والـ Development، تتوجه باتجاه الـ Female،
+
+93
+00:10:15,980 --> 00:10:21,090
+يعني هذه ناحية مهمة. فإذا كان فيه Y-Chromosome، بينتج
+
+94
+00:10:21,090 --> 00:10:26,070
+عنه أنه تتحول لقضية الـ Testicles، و Spermatogenesis،
+
+95
+00:10:26,070 --> 00:10:31,090
+وفيه Androgens زي التستوستيرون، وبعطينا الـ Male
+
+96
+00:10:31,090 --> 00:10:35,010
+Internal و External Genitalia و Characteristics. إذا
+
+97
+00:10:35,010 --> 00:10:40,370
+ما فيه، الأمور باتجاهها بتكون Female، فهذه ناحية
+
+98
+00:10:40,370 --> 00:10:41,070
+مهمة.
+
+99
+00:10:44,550 --> 00:10:52,130
+بالنسبة لـ… يعني هناك اختلالات أو بتحدث ظواهر
+
+100
+00:10:52,130 --> 00:10:59,990
+كثيرة في هذا الأمر. ماشي، بس النقطة المهمة، إنه يعني
+
+101
+00:10:59,990 --> 00:11:03,890
+الأهم هو الـ X-Chromosome. الـ X-Chromosome عليه
+
+102
+00:11:03,890 --> 00:11:09,970
+عدد كبير من الجينات، مسؤول عنه كثير من التكون، وفي
+
+103
+00:11:09,970 --> 00:11:17,230
+أشياء كثيرة عليه، يعني يمكن 1500 جين. يعني بالنسبة
+
+104
+00:11:17,230 --> 00:11:24,210
+للـ X-Chromosome، مهما كان عدد النسخ تبع الـ X
+
+105
+00:11:24,210 --> 00:11:28,570
+-Chromosome، واحد منها فقط هو الشغال، الـ Active
+
+106
+00:11:28,570 --> 00:11:33,930
+بيكون، راح يكون Active، والبقية راح تكون نسميهم Barr
+
+107
+00:11:33,930 --> 00:11:40,510
+Bodies، و Inactive. وأنا حاطط أمثلة إن هاي الـ
+
+108
+00:11:40,510 --> 00:11:46,210
+Normal Female، الأول واحدة، اللي إحنا شايفينه هو 46
+
+109
+00:11:46,210 --> 00:11:51,690
+كروموزوم، زي ما نعمله كاريوتايب، وكان XX. فبهذا
+
+110
+00:11:51,690 --> 00:11:58,290
+الشكل، فيه هناك بيسموها Super Female، ممكن تلاقي شخص
+
+111
+00:11:58,290 --> 00:12:01,730
+أو أنثى، عندها 47 كروموزوم،
+
+112
+00:12:05,010 --> 00:12:09,610
+الأصلية اللي هم الأربع وعشرون pair، زائد
+
+113
+00:12:09,610 --> 00:12:18,230
+XXX، أو XXXX، أو… يعني حتى أربع نسخ من inactive
+
+114
+00:12:18,230 --> 00:12:27,170
+form of X-chromosome. فلو كان مثلًا في الـ Male،
+
+115
+00:12:27,170 --> 00:12:31,850
+مظهريًا، اللي بيسموه Turner Syndrome، بتلاقوا عندها
+
+116
+00:12:31,850 --> 00:12:38,250
+45,X0. الـ O يعني مافيش عندها نسخة ثانية. فبلاقي لما
+
+117
+00:12:38,250 --> 00:12:44,230
+نعمل دراسة بهذا الشكل، كـ Karyotype، أو عشان ندور
+
+118
+00:12:44,230 --> 00:12:48,430
+على الـ Inactive X-Chromosome، نلاقي فيه صفر، مافيش
+
+119
+00:12:48,430 --> 00:12:54,110
+فيه. نفس الظاهرة ممكن تحدث في الـ Males، عادةً الـ
+
+120
+00:12:54,110 --> 00:13:00,710
+Male، أهم جانب، بشكل طبيعي، أنه وجود الـ Y، ما ندخل عدد
+
+121
+00:13:00,710 --> 00:13:13,330
+نسخ الـ X. ماشي، في أسئلة هنا؟ بقول لكم، بالنسبة، نتوقع
+
+122
+00:13:13,330 --> 00:13:20,710
+يعني كيف بالنسبة للـ Females، راح نلاقي إنه
+
+123
+00:13:21,290 --> 00:13:28,770
+في كل خلية، أو مجموعة خلايا، بتلاقي أحد نسختين الـ X
+
+124
+00:13:28,770 --> 00:13:33,850
+-Chromosome inactive، يا إما الـ X اللي جاي من الأب،
+
+125
+00:13:33,850 --> 00:13:39,790
+أو الـ X اللي جاي من الأم. فهي يعني أحيانًا بتأثر
+
+126
+00:13:39,790 --> 00:13:49,260
+على… يعني إذا مثلًا في مرض عند الأب، بتلاقي، أو
+
+127
+00:13:49,260 --> 00:13:55,960
+بالعكس. يعني مثلًا، هناك أنثى حاملة لـ Gene، لـ
+
+128
+00:13:55,960 --> 00:14:00,760
+Gene على الـ X-Chromosome، وفيه مرض، فإيه الأصل؟
+
+129
+00:14:00,760 --> 00:14:04,880
+بنقول هي حاملة، وغير مصابة. غير مصابة، يعني مافيش
+
+130
+00:14:04,880 --> 00:14:10,990
+عندها مشكلة. وبيكون، إذا كان عندها مظهر، بعض مظاهر
+
+131
+00:14:10,990 --> 00:14:15,750
+المشكلة، بيكون إنه هاي في الخلايا اللي… إن النسخة
+
+132
+00:14:15,750 --> 00:14:19,010
+الموروثة من الأب، هي اللي فاعلة، أو هي اللي active،
+
+133
+00:14:19,010 --> 00:14:27,370
+فهي أحيانًا ظاهرة بتحدث فيها. سؤال؟
+
+134
+00:14:27,370 --> 00:14:33,070
+الآن بالنسبة
+
+135
+00:14:33,070 --> 00:14:40,310
+للأمراض والمشاكل اللي هي فيه Abnormalities في الـ
+
+136
+00:14:40,310 --> 00:14:44,390
+Sex Chromosomes، يعني الـ Whole Chromosome Anomaly،
+
+137
+00:14:44,390 --> 00:14:50,190
+فيه مرض اسمه Klinefelter syndrome. البقية بدنا نسيبها، يعني
+
+138
+00:14:50,190 --> 00:15:03,130
+ناشي الـ… الـ… بالنسبة لـ Klinefelter syndrome، بتلاقي 47
+
+139
+00:15:03,130 --> 00:15:06,690
+كروموزوم،
+
+140
+00:15:06,690 --> 00:15:14,170
+الـ Total موجود، و 44، أو 22 زوج autosomes، وبعدين الـ
+
+141
+00:15:14,170 --> 00:15:20,750
+sex chromosomes، في XXY، ماشي؟ هذه تقريبًا واحد في كل
+
+142
+00:15:20,750 --> 00:15:29,330
+600 ذكر. حوالي تقريبًا… في أحدكم بعت لي سؤال، نحفظ
+
+143
+00:15:29,330 --> 00:15:33,430
+الأرقام هذه؟ أنا بقول ما في داعي الواحد يحفظها،
+
+144
+00:15:33,430 --> 00:15:39,330
+بقدر ما إنه يعني ينتبه لعلاقاتهم مع بعض، اللي هي
+
+145
+00:15:39,330 --> 00:15:46,350
+قضية إنه مثلًا، أشيع مرض اللي هو Klinefelter syndrome، ماشي؟
+
+146
+00:15:46,350 --> 00:15:52,350
+حوالي واحد في ستمية، ماشي؟ بالـ Females، أكثر أشيع
+
+147
+00:15:52,350 --> 00:15:57,550
+شيء هو الـ Turner syndrome، واحد في كل أربعة آلاف، ماشي؟
+
+148
+00:15:57,940 --> 00:16:02,000
+فأحيانًا إنك تشوف رقم واحد هيك، تنتبهي إن هو رقم
+
+149
+00:16:02,000 --> 00:16:07,960
+واحد. ناحية مهمة، دكتور، في سؤال كريم، بيتكلم عن الـ
+
+150
+00:16:07,960 --> 00:16:11,800
+Inactivation للـ X، بيسأل كيف بيصير، يعني بيسأل عن
+
+151
+00:16:11,800 --> 00:16:17,970
+الـ Mechanism. المطلوب، زي ما شفنا في النسخ اللي فيها
+
+152
+00:16:17,970 --> 00:16:25,470
+Barr Bodies، إنه في أي خلية، واحد من الـ X
+
+153
+00:16:25,470 --> 00:16:31,250
+-Chromosomes هو اللي وحيد اللي شغال، فبالظبط كيف
+
+154
+00:16:31,250 --> 00:16:37,730
+بيحدث؟ ليش بيحدث بهذه الطريقة؟ يعني ما… ماعندي يعني
+
+155
+00:16:37,730 --> 00:16:43,510
+تفسير، بقدر ما إنها هي هيك بتحدث، هيك ربنا حاططها،
+
+156
+00:16:43,510 --> 00:16:54,020
+فينافها. الآن هذول أربع إناث، ماشي؟ لما نيجي، وحاطين هنا
+
+157
+00:16:54,020 --> 00:17:01,260
+صورة… بعدين التوزيع، يعني كم لو جبت ألف أنثى، أو
+
+158
+00:17:01,260 --> 00:17:06,980
+درست الـ X-Chromosomes تبعينهم، هتلاقي الغالبية العظمى،
+
+159
+00:17:06,980 --> 00:17:16,860
+XX، وأمور طبيعية، بشكل يعتبر عشوائي، Random، يعني مش
+
+160
+00:17:16,860 --> 00:17:22,760
+شيء مقصود، هيك يظن يعني، ماشي. الغالبية العظمى راح
+
+161
+00:17:22,760 --> 00:17:29,900
+تلاقوا إنه في واحد فقط من النسخ تبعات الـ X، هي
+
+162
+00:17:29,900 --> 00:17:37,720
+النشطة، هي الـ Euchromatin بسموها، يعني هي اللي فايته
+
+163
+00:17:37,720 --> 00:17:45,540
+الحبل أو الخيط تبع الـ DNA، بدل ما هو مضغوط وقت الـ
+
+164
+00:17:45,540 --> 00:17:50,480
+Cell Division، لأ، بيكون مفكوك، عشان يتم قراءة
+
+165
+00:17:50,480 --> 00:17:56,240
+الجينات اللي عليه. فهذا راح يكون نسخة واحدة بس هي
+
+166
+00:17:56,240 --> 00:18:03,870
+شغالة. بهذه الطريقة، البقية بتكون Inactive. فحسب إذا
+
+167
+00:18:03,870 --> 00:18:08,950
+كانت هذه الـ Normal Female اللي هي الـ XX، بتلاقي
+
+168
+00:18:08,950 --> 00:18:15,530
+بتشوف هيك واحد Barr Body، اللي هو شو اسمه؟ اللي هو
+
+169
+00:18:15,530 --> 00:18:22,390
+Inactive X-Chromosome. إذا عندها XXX، بتكون واحد
+
+170
+00:18:22,390 --> 00:18:29,270
+Active، واثنين Inactive. إذا XXXX، أربع نسخ، واحد
+
+171
+00:18:29,270 --> 00:18:34,590
+active، وثلاثة inactive، بالشكل هذا. لماذا
+
+172
+00:18:34,590 --> 00:18:42,670
+بالضبط هكذا تحصل؟ أنا ما بعرف، ماعندي تفسير بشكل
+
+173
+00:18:42,6
+
+223
+00:23:56,340 --> 00:24:03,480
+الـAndrogen، بس وظيفة الهرمونات الذكرية غير فاعلة
+
+224
+00:24:03,480 --> 00:24:12,820
+ففي هذا المظهر، بتلاقيها مظهريًا بتبين أنثى، يعني
+
+225
+00:24:12,820 --> 00:24:20,430
+الأداء المجلة الـ bowling خارجي ماشي بيكون على شكل
+
+226
+00:24:20,430 --> 00:24:28,950
+أنثى، و.. بس من جوا الـ gonads والتراكيب الداخلية
+
+227
+00:24:28,950 --> 00:24:36,930
+يعني ما عندها رحم، ما عندها مبايض، بتلاقي موجود شو
+
+228
+00:24:36,930 --> 00:24:46,920
+اسمه اللي هو خصية جوا، وتراكيب ثانية، ومشبك التراكيب
+
+229
+00:24:46,920 --> 00:24:52,760
+الخارجية، المهبل بتلاقيه موجود، وهذولة ميزتهم يعني
+
+230
+00:24:52,760 --> 00:24:59,140
+حتى لو واحد يتذكر هذه الحالة، بتقول إن الشعر في
+
+231
+00:24:59,140 --> 00:25:08,620
+منطقة العانة والإبط مش موجود، هذولة يعني حالة خاصة
+
+232
+00:25:08,620 --> 00:25:15,330
+بيقول فيها Y-Chromosome بس مش شغال، كأنه مش موجود
+
+233
+00:25:15,330 --> 00:25:21,630
+وبشبه نظريًا الـ Female، بتكون الأمور مخربطة، ماشي؟
+
+234
+00:25:21,630 --> 00:25:27,300
+فهذولة الحالة اللي بنعتبرها ثالثة بشكل عام، الـ Klinefelter
+
+235
+00:25:27,300 --> 00:25:31,780
+Syndrome، والـ Turner Syndrome، أذكروهم طبعًا Super Female أو
+
+236
+00:25:31,780 --> 00:25:40,360
+XXY بيكون اللي هو XXY Klinefelter Syndrome أو أكثر، XXXY أو
+
+237
+00:25:40,360 --> 00:25:46,580
+غيره، ماشي؟ وفي اللي هو الـ Androgen Insensitivity
+
+238
+00:25:46,580 --> 00:25:52,260
+Syndrome، اللي هو بيكون نوعية ثالثة، بيكون صح الـ Y
+
+239
+00:25:52,260 --> 00:25:56,720
+موجود، بس مش شغال، كأنه مش موجود، وبالتالي فبتطلع
+
+240
+00:25:56,720 --> 00:25:57,720
+الأمور مقلوبة
+
+241
+00:26:05,730 --> 00:26:15,210
+هنا تفاصيل أكثر عن إيش يعني الـ «Klinefelter Syndrome»
+
+242
+00:26:15,210 --> 00:26:19,910
+حكينا تقريبًا هو واحد على ألف وواحد على ستمائة
+
+243
+00:26:19,910 --> 00:26:29,120
+بيكون طولهم طويل، يعني هنا الـ… بيكونوا في عندهم مشاكل
+
+244
+00:26:29,120 --> 00:26:33,600
+في الخصية وما بيستطيعوا يعني فيه Hypogonadism،
+
+245
+00:26:33,600 --> 00:26:38,420
+أزوسبيرميا، Infertility، وبيكونوا في عندهم مشاكل
+
+246
+00:26:38,420 --> 00:26:46,180
+الـXYY بالنسبة للـSex Development طبيعي، برضه Tall
+
+247
+00:26:46,180 --> 00:26:49,860
+Male، يعني
+
+248
+00:26:49,860 --> 00:26:56,170
+هو بيحاولوا الـ… يعطوكم المظاهر
+
+249
+00:26:56,170 --> 00:27:02,690
+تبعيتهم، وبالنسبة للـ Turner اللي هو الواحد في كل
+
+250
+00:27:02,690 --> 00:27:08,670
+أربعة آلاف تقريبًا، بـ Short Stature، بيكون قصيرة في
+
+251
+00:27:08,670 --> 00:27:15,070
+الـ Web Neck، اللي هو جلد زائد على الرقبة، بيكون زي
+
+252
+00:27:15,070 --> 00:27:21,620
+الغشاء هيك على جانب، طالع، Risk of Cardiac Anomalies،
+
+253
+00:27:21,620 --> 00:27:30,020
+عادة الـ Mental ممكن Typically Normal، بس أحيانًا
+
+254
+00:27:30,020 --> 00:27:36,690
+بيكون فيه Retardation شوية، أو الـ Impaired Social
+
+255
+00:27:36,690 --> 00:27:43,050
+Adjustments، يعني هون الأمثلة على الأمراض الأساسية
+
+256
+00:27:43,050 --> 00:27:48,250
+تبعات الـ X-Chromosome Abnormalities، أو الـ Sex
+
+257
+00:27:48,250 --> 00:27:53,050
+Chromosome Anomalies، ماشي؟ في أسئلة أخرى؟
+
+258
+00:27:58,010 --> 00:28:07,450
+الآن تكرار تفاصيل الجينات المسؤولة عن تكوين الخصية
+
+259
+00:28:07,450 --> 00:28:12,690
+والبربخ والقناة، مجرى البول بالشكل هذا عند الذكور
+
+260
+00:28:12,690 --> 00:28:26,440
+وعند الإناث وكذا، بدنا إيش يعني؟ ماشي؟ تفاصيل التعقيد
+
+261
+00:28:26,440 --> 00:28:34,420
+الأكثر من الـ Sex chromosomes، وبعدين
+
+262
+00:28:34,420 --> 00:28:38,640
+الجينات اللي على الـ Sex chromosomes، وكيف تتحكم في
+
+263
+00:28:38,640 --> 00:28:43,830
+أن المظهر يكون بالشكل هذا، اللي راح فيه عندنا حالة
+
+264
+00:28:43,830 --> 00:28:49,130
+يعني إذا بتعرفوها «precocious puberty»، يعني
+
+265
+00:28:49,130 --> 00:28:55,850
+البلوغ المبكر، بتلاقي أنثى أو ذكر، طبعًا بالأول
+
+266
+00:28:55,850 --> 00:29:02,900
+الإنسان، يعني بيولد بطول وحجم معين، بتلاقي المرحلة
+
+267
+00:29:02,900 --> 00:29:09,720
+الطفولة، بتلاقي الإنسان ما عنده مظاهر جنسية، نموه
+
+268
+00:29:09,720 --> 00:29:14,620
+بشكل عام، بعد أول سنة بيصير يبطأ يبطأ لحد ما تيجي
+
+269
+00:29:14,620 --> 00:29:21,180
+فترة البلوغ، وبعدين بتلاقي نموه بشد بشكل كبير، فاللي
+
+270
+00:29:21,180 --> 00:29:30,010
+عنده بلوغ مبكر، ماشي؟ بتلاقي أولًا، أولها بيتلاقي فترة
+
+271
+00:29:30,010 --> 00:29:34,950
+وارتفاع بشكل كبير، وصار النمو عنده في الطول وفي
+
+272
+00:29:34,950 --> 00:29:40,810
+المظاهر كبير، بس بعدين في المحصلة النهائية راح تكون
+
+273
+00:29:40,810 --> 00:29:46,150
+إنه هو راح يطلع طوله أقصر من غيره اللي بتأخره، بس
+
+274
+00:29:46,150 --> 00:29:51,170
+بيضلوا مدة أكبر وهو ينمو، فهذه المظاهر بتأثر على
+
+275
+00:29:51,170 --> 00:29:55,860
+أشياء كثيرة، وبالأخير يعني كمان نحكي إنه غير هذه
+
+276
+00:29:55,860 --> 00:29:59,620
+الأمور كعوامل
+
+277
+00:29:59,620 --> 00:30:06,420
+مؤثرة على نمو وتطور الإنسان الجنسي، كما تتدخل فيها
+
+278
+00:30:06,420 --> 00:30:13,620
+الجوانب الاجتماعية والمجتمعية، وتعامل المجتمع معه
+
+279
+00:30:13,620 --> 00:30:23,500
+وتقبل الناس له كشخص واضح، حتى
+
+280
+00:30:23,500 --> 00:30:30,660
+في الشارع، يوجد مباحث معينة تقول الخنثى يعني شخص
+
+281
+00:30:30,660 --> 00:30:36,540
+أعضائه مش مبينة، هي ذكر ولا أنثى، هذه آه والله
+
+282
+00:30:36,540 --> 00:30:41,420
+بتحدث، وأحيانًا في ناس هيك، وكيف ده بتتعامل معاه،
+
+283
+00:30:41,420 --> 00:30:47,860
+فيه له جانب في الطب، أطباء يعني الغدد الصماء
+
+284
+00:30:47,860 --> 00:30:52,600
+بتدخلوا فيها، أطباء المسالك البولية، أو أطباء
+
+285
+00:30:52,600 --> 00:31:01,300
+النسائية، بتلاقي يعني فيه تخصصات في الطب بيدرسوا
+
+286
+00:31:01,300 --> 00:31:07,720
+يعني كيفية… يعني فيه اللي بيسموه true hermaphrodite،
+
+287
+00:31:07,720 --> 00:31:13,020
+true hermaphrodite، اللي هو يعني الخنثى الحقيقية
+
+288
+00:31:13,020 --> 00:31:21,480
+بتلاقي شخص عنده خصية، ومثلاً قضيب، وذكر، ويحيط
+
+289
+00:31:21,480 --> 00:31:26,640
+فيه رحم حقيقي بالداخل، حيث أنه بتصير دورة شهرية
+
+290
+00:31:26,640 --> 00:31:32,320
+وبنزل الدم، بتلاقي أحيانًا يعني أشخاص عندهم
+
+291
+00:31:32,320 --> 00:31:40,040
+ابتلاءات وأمراض بتكون إنه التطور الجنسي غير كامل،
+
+292
+00:31:40,040 --> 00:31:45,920
+غير واضح، غير سليم، يعني هناك إشكالية فيها، فهذه
+
+293
+00:31:45,920 --> 00:31:49,180
+جوانب
+
+294
+00:31:49,180 --> 00:31:57,310
+يعني خليني على الأمثلة الكبيرة، يعني اللي حطيناها
+
+295
+00:31:57,310 --> 00:32:04,290
+قبل شوية، وخلينا الأمثلة كبيرة، ونفهم تداخلها ما
+
+296
+00:32:04,290 --> 00:32:11,510
+بين أولًا كروموزومات، لجينات، لهرمونات، لتراكيب، بعد
+
+297
+00:32:11,510 --> 00:32:20,430
+ذلك تدخل في قضية يعني كيف المجتمع يتعامل مع هذا
+
+298
+00:32:20,430 --> 00:32:27,990
+الموضوع، يعني إذا التراكيب البولية الخارجية مش واضحة،
+
+299
+00:32:27,990 --> 00:32:33,810
+أحيانًا بتضطر حتى عمر صغير، أحيانًا الجراح
+
+300
+00:32:33,810 --> 00:32:38,410
+بتضطر يدخل ويعدل ويظبط وكذا، إذا مثلًا فيه
+
+301
+00:32:38,410 --> 00:32:45,500
+hypospadias، بتكون فتحة قناة مجرى البول عند الولد
+
+302
+00:32:45,500 --> 00:32:53,880
+يعني فيها مشكلة، وبتلاقي الجراح مثلاً بدخل، بظبطها ب
+
+303
+00:32:53,880 --> 00:32:58,420
+… ب… ب… في عمليات طبعًا تسمعوا عنها للناس
+
+304
+00:32:58,420 --> 00:33:02,960
+أحيانًا نتيجة هذه المشكلة بيصير عنده مرض نفسي، ومش
+
+305
+00:33:02,960 --> 00:33:07,100
+عارف حاله ولد ولا بنت، ذكر ولا أنثى، ويصير يطلب
+
+306
+00:33:07,100 --> 00:33:16,800
+يغيروا جنسه، يعني هذه أشياء… يعني صحيح المجتمعات اللي
+
+307
+00:33:16,800 --> 00:33:23,200
+بتدخل فيها أحيانًا، ولكن أيضًا الـ… يعني في أحيانًا
+
+308
+00:33:23,200 --> 00:33:31,700
+بشر عندهم مرض، وبكون ما بين يعني هرموناته،
+
+309
+00:33:31,700 --> 00:33:38,760
+جيناته، كروموزوماته، بتكون الأمور مختلفة، زائد تأثير
+
+310
+00:33:38,760 --> 00:33:43,390
+المجتمع، يعني كيف الأهل بيربوا الولد أو بيربوا البنت،
+
+311
+00:33:43,390 --> 00:33:47,770
+يعني البنت بيجيبوا لها لعب، بيلبسوا لها بشكل حلو،
+
+312
+00:33:47,770 --> 00:33:53,070
+بيهتموا فيها بطريقة مختلفة، اللعب اللي بتكون وكذا،
+
+313
+00:33:53,070 --> 00:33:57,970
+أحيانًا هي بتأثر نفسيًا على حتى تطور الإنسان، بعد
+
+314
+00:33:57,970 --> 00:34:06,830
+ذلك، فلحد هنا، هاي اللي هي المواضيع اللي يعني
+
+315
+00:34:09,650 --> 00:34:14,250
+المواضيع اللي بنعتبر كانت
+
+316
+00:34:14,250 --> 00:34:18,430
+في قضية الـ
+
+317
+00:34:18,430 --> 00:34:23,510
+«Closed Zone»؟ لأ، خليني أشوف، أساسًا ندخل على
+
+318
+00:34:23,510 --> 00:34:31,990
+المحاضرة التالية، في أسئلة؟ في حد في عنده صعوبة في
+
+319
+00:34:31,990 --> 00:34:35,330
+شغلة؟ «Genetics»؟
+
+320
+00:34:38,950 --> 00:34:54,170
+عشان أفتح المحاضرة اللي بعدها هسا
+
+321
+00:34:54,170 --> 00:35:04,130
+المجموعة اللي بعدها، إحنا خلصنا أكبر أو المجموعة
+
+322
+00:35:04,130 --> 00:35:11,360
+اللي مميز لها كثرة المظاهر المرضية، بسبب أنه عدد
+
+323
+00:35:11,360 --> 00:35:18,260
+الجينات المشتركة في قضية الاختلال، نتيجة أن
+
+324
+00:35:18,260 --> 00:35:22,600
+الكروموزوم كله فيه شيء غلط، فراح ينتج عنه عادة
+
+325
+00:35:22,600 --> 00:35:30,600
+أمراض شديدة، وبتكون أحيانًا كثيرة، يعني غير not
+
+326
+00:35:30,600 --> 00:35:35,180
+compatible even with life، يعني أشياء زي ما حكينا
+
+327
+00:35:35,600 --> 00:35:43,200
+مرتبطة أكثر بقضية الـ Abortions، حالات الإجهاض
+
+328
+00:35:43,200 --> 00:35:48,860
+وبتكون نتيجة إنه عدد كبير من الجينات بتكون مصابة
+
+329
+00:35:48,860 --> 00:35:53,930
+أو مختلة، سواء بالزيادة، بالنقصان، بالتغيير،
+
+330
+00:35:53,930 --> 00:35:58,550
+بالتخريب، بالـ «كذا»، ففيها أشياء كثيرة، في سؤال من
+
+331
+00:35:58,550 --> 00:36:04,510
+«مروة سماح»، قالت يعني دكتور مش مطلوب منا نعرف
+
+332
+00:36:04,510 --> 00:36:07,410
+الأمراض الناتجة عن خلل بالجينات، بس نقتصر على
+
+333
+00:36:07,410 --> 00:36:13,990
+الأمراض الرئيسية؟ لأ، أنا يعني مش مطلوب، ومطلوب
+
+334
+00:36:13,990 --> 00:36:21,760
+يعني لو واحد قرأ وحاول يفهم ونجح، ممتاز، كويس يصير
+
+335
+00:36:21,760 --> 00:36:26,660
+عنده معلومات أكثر، بس أنا بتكلم أنه تفاصيل الأمور
+
+336
+00:36:26,660 --> 00:36:31,660
+يعني على إيش الجينات الموجودة على الـ Y-Chromosome
+
+337
+00:36:31,660 --> 00:36:38,340
+وشو الآليات اللي بتخلي هذا الرجل يصير شكله رجل؟ لأنه اللي
+
+338
+00:36:38,340 --> 00:36:43,320
+بيأثر على الشعر، أنه اللي بيأثر شعر اللحية، يعني
+
+339
+00:36:43,320 --> 00:36:49,540
+ليش صوته بقى جش، وحجم الحنجرة أكبر؟ ليش الـSperms
+
+340
+00:36:49,540 --> 00:36:53,180
+هم اللي بيطلعوا؟ كيف بيسيطر؟ يعني تفاصيل الأمور،
+
+341
+00:36:53,180 --> 00:37:01,560
+خلاص اتركوني، ماشي؟ ما تقعد تدقق وكذا وهكذا،
+
+342
+00:37:01,560 --> 00:37:10,470
+ماشي؟ ما تشدّود، بشدّ عليكم، فاتركوا الموضوع، أهم
+
+343
+00:37:10,470 --> 00:37:15,490
+شيء المبادئ، الـ Barr body يمثل Inactive X-Chromosome،
+
+344
+00:37:15,490 --> 00:37:20,150
+فشو ما كان فيه X-Chromosomes Inactive راح يبين
+
+345
+00:37:20,150 --> 00:37:26,750
+عددهم بشكل، Barr body الأصلي في مظهر الرجل، يعني الـ
+
+346
+00:37:26,750 --> 00:37:31,930
+Default، لو ما فيش شيء، بتطلع أنثى، يعني الإعداد
+
+347
+00:37:31,930 --> 00:37:36,390
+الافتراضي لـ System البشر ربنا حطّه إنه تطلع
+
+348
+00:37:36,390 --> 00:37:43,030
+بالأول أنثى، ماشي؟ وجود الـ Y هو اللي بيُبينه على
+
+349
+00:37:43,030 --> 00:37:47,610
+شكل الرجل، فأهمية الـ Y، هذه ناحية ثانية، الشغل
+
+350
+00:37:47,610 --> 00:37:52,550
+الثالث إنه صح لو الـ Y موجود، بس برضه مش ضروري إنه
+
+351
+00:37:52,550 --> 00:37:58,650
+يطلع ذكر، ممكن يكون Y بس يكون شكلها أنثى، ويكون أمور
+
+352
+00:37:58,650 --> 00:38:02,760
+مخربطة من جوا، ماشي؟ خلينا نحطها بهذا الشكل
+
+353
+00:38:02,760 --> 00:38:08,200
+الجداول اللي حطيتها، أو الصور اللي حطيتها
+
+354
+00:38:08,200 --> 00:38:16,200
+بالنسبة للشكل، Klinefelter Syndrome، Turner Syndrome، كيف بتكون، هاي آه
+
+355
+00:38:16,200 --> 00:38:21,820
+هي حكيتها وذكرناها، تفاصيل أكثر من هيك، exact
+
+356
+00:38:21,820 --> 00:38:25,620
+details ما بدنا إياها، في شيء ثاني؟
+
+357
+00:38:28,670 --> 00:38:33,030
+تمام يا دكتور، لا شيء يعني، لحد اللي أنا نفسي طيب،
+
+358
+00:38:33,030 --> 00:38:36,270
+الآن
+
+359
+00:38:36,270 --> 00:38:42,770
+بدنا ندخل على اللي بيسموها الوراثة المندلية، اللي
+
+360
+00:38:42,770 --> 00:38:50,630
+هي الأمراض والحالات والمشاكل اللي بيكون single
+
+361
+00:38:50,630 --> 00:39:02,780
+gene هو المسؤول عنها، وهذولة يعني صحيح، يعني حتلاقي
+
+362
+00:39:02,780 --> 00:39:07,620
+أعدادهم بالألوف، يعني الـ Online Mendelian
+
+363
+00:39:07,620 --> 00:39:15,820
+Inheritance Website، حتلاقي حوالي يعني بعشرات
+
+364
+00:39:15,820 --> 00:39:22,260
+الآلاف من الأمراض، وهناك مراجع ويتم تحديثها دائمًا
+
+365
+00:39:22,260 --> 00:39:35,950
+بقضايا يعني بقضايا جديدة، أنا بس بدي أحط صورة، وديتها
+
+366
+00:39:35,950 --> 00:39:43,690
+للدكتور أحمد الأسبوع اللي فات، فخليني
+
+367
+00:39:43,690 --> 00:39:48,830
+بس أضيفها، هاي
+
+368
+00:39:48,830 --> 00:39:49,730
+هنا
+
+369
+00:39:53,470 --> 00:40:04,470
+خليني أشوف إذا بتبين هنا، لأ مش هذا، ما هو اسمه؟
+
+370
+00:40:04,470 --> 00:40:09,650
+Save image على
+
+371
+00:40:09,650 --> 00:40:11,430
+الـ desktop، ماشي
+
+372
+00:40:21,420 --> 00:40:25,340
+دكتور أنت ما تنسخها داخل مربع النص، انسخها على
+
+373
+00:40:25,340 --> 00:40:28,400
+الشريحة نفسها، يعني خارج الشريحة، يعني انقر خارج
+
+374
+00:40:28,400 --> 00:40:34,660
+الشريحة، والصقها، طيب خليني أشوف دقيقة، دقيقة، دقيقة،
+
+375
+00:40:34,660 --> 00:40:38,340
+دقيقة، دقيقة، دقيقة،
+
+376
+00:40:38,340 --> 00:40:41,340
+دقيقة، دقيقة، دقيقة، دقيقة، دقيقة، دقيقة، دقيقة،
+
+377
+00:40:41,340 --> 00:40:43,220
+دقيقة، دقيقة، دقيقة، دقيقة، دقيقة، دقيقة، دقيقة،
+
+378
+00:40:43,220 --> 00:40:46,380
+دقيقة، دقيقة، دقيقة، دقيقة، دقيقة، دقيقة، دقيقة،
+
+379
+00:40:46,380 --> 00:40:47,800
+دقيقة، دقيقة، دقيقة، دقيقة، دقيقة، دقيقة، دقيقة،
+
+380
+00:40:47,800 --> 00:40:50,410
+دقيقة، دقيقة، دقيقة، دقيقة، دقيقة، هذه صورة من
+
+381
+00:40:50,410 --> 00:41:01,110
+عندي، يعني عبارة عن عائلة اللي بتحكيها، عبارة
+
+382
+00:41:01,110 --> 00:41:06,990
+عن أب وأم، هما أخوة من سوريا، في قرابة بين الأب
+
+383
+00:41:06,990 --> 00:41:16,450
+والأم، عندهم تسعة أبناء وبنات، التسعة، خمسة منهم بطلع
+
+384
+00:41:16,450 --> 00:41:23,710
+على أيديهم ورجليهم وعلى رأسهم تدرنات بهذا الشكل،
+
+385
+00:41:23,710 --> 00:41:34,350
+ماشي؟ هذه الظاهرة، يعني أول شيء طبعًا لما واحد
+
+386
+00:41:34,350 --> 00:41:40,610
+يتعرف على عائلة بهذا الشكل، ماشي؟ النقطة الأساسية
+
+387
+00:41:40,610 --> 00:41:47,910
+أولًا يعني لازم يحاول يروح يدور في المراجع العلمية،
+
+388
+00:41:47,910 --> 00:41:53,370
+ويحاول يشوف إذا فيه شيء حد ذكر حالة قريبة، حالة
+
+389
+00:41:53,370 --> 00:42:01,430
+يعني مشابهة، حالة قريبة منها، فأقرب شيء لهذا المنظر
+
+390
+00:42:01,430 --> 00:42:04,670
+عبارة عن حالة تسمى «Infantile Digital
+
+391
+00:42:04,670 --> 00:42:13,740
+Fibromatosis»، يعني في الأطفال على
+
+392
+00:42:13,740 --> 00:42:23,880
+الأصابع يكون هناك تليفات، يعني أنا حتى الأقرب شيء
+
+393
+00:42:23,880 --> 00:42:31,420
+بستطيع أقول إنه
+
+445
+00:47:42,590 --> 00:47:48,950
+مش مُجعلة يعني فكل صفة من اللي كان بدرسها مندل
+
+446
+00:47:48,950 --> 00:47:53,890
+كانت على كروموزوم مختلف، وبالتالي أعطتنا شكل معين من
+
+447
+00:47:53,890 --> 00:47:59,230
+كان استطاع أن ينتبه لمبادئ في الوراثة مهمة كثيرة، بس
+
+448
+00:47:59,230 --> 00:48:04,930
+لأنه كمان أن الحق خدمه أن الصفات اللي درسها كانت
+
+449
+00:48:04,930 --> 00:48:12,210
+منفصلة عن بعضها. أما لو تخيلنا أن صفتين قريبتين على
+
+450
+00:48:12,210 --> 00:48:17,370
+بعض في نفس الـChromosome، إذا مثلاً إنسان عنده شيء
+
+451
+00:48:17,370 --> 00:48:23,190
+سائد مع أحدهما مثلاً متنحي مع الآخر، راح تصير عملية
+
+452
+00:48:23,190 --> 00:48:26,810
+الوراثة وعملية انتقال الصفات الوراثية راح تكون
+
+453
+00:48:26,810 --> 00:48:33,270
+خربطة، أو مش بالسهولة اللي بنتكلم عنها. من الأشياء
+
+454
+00:48:33,270 --> 00:48:36,690
+اللي سويتها على طول للعائلة السورية اللي أنا
+
+455
+00:48:36,690 --> 00:48:45,070
+سويتها، قضية أنه يرسم الواحد شجرة العائلة، شجرة
+
+456
+00:48:45,070 --> 00:48:54,210
+العائلة، مجرد حتى يعني، يعني يقترب للطبيب أو الباحث
+
+457
+00:48:54,210 --> 00:49:00,400
+من احتمالية أن يكون هناك مرض وراثي. وممكن الواحد
+
+458
+00:49:00,400 --> 00:49:05,640
+يشترك مع العالم كله أنه يعني بعدين يلاقي وين الجين
+
+459
+00:49:05,640 --> 00:49:09,720
+المسؤول عن هذا الأمر. فيه هناك عدد كبير من الجينات
+
+460
+00:49:09,720 --> 00:49:14,100
+نحن لا نعلم ما وظيفتها بالضبط، ليش ربنا حطها فينا،
+
+461
+00:49:14,100 --> 00:49:19,360
+وكيف بتشتغل، كيف بتعمل، لسه فيه مجاهيل كثيرة،
+
+462
+00:49:19,360 --> 00:49:25,240
+وبدال الواحد دائماً يشترك أنه يطور الموضوع، فأهم شيء
+
+463
+00:49:25,240 --> 00:49:32,500
+أنه بالأول، بأول ما يشوف الحالة، يرسم شجرة العائلة،
+
+464
+00:49:32,500 --> 00:49:38,220
+يرسم اللي بيسموه الـPedigree، اللي هو الشجرة
+
+465
+00:49:38,220 --> 00:49:46,320
+العائلة للإصابة وللعائلة المصابة، وبالتالي يعني يجمع
+
+466
+00:49:46,320 --> 00:49:57,540
+تفاصيل في شكل يعني بسيط، ويعني جدول صغير، حجمه صغير،
+
+467
+00:49:57,540 --> 00:50:05,120
+بس يحط فيه معلومات كبيرة جداً جداً. فالآن الـ
+
+468
+00:50:05,120 --> 00:50:10,440
+Pedigree بتبدأ أن الواحد لازم يميز الرموز الموجودة
+
+469
+00:50:10,440 --> 00:50:19,060
+لما نحط مربع، فالمقصود فيه Male، هو ذكر. المستديرة
+
+470
+00:50:19,060 --> 00:50:27,340
+Female. إذا حطّها مُعين، فإنه يكون sex unspecified، يعني
+
+471
+00:50:27,340 --> 00:50:34,720
+مثلاً إجهاض مبكر، وكان مش مبين أن هذا ذكر ولا أنثى.
+
+472
+00:50:34,720 --> 00:50:42,630
+والله جدة أمي كان عندها سبعة أبناء وبنات. طب قداش
+
+473
+00:50:42,630 --> 00:50:47,030
+الذكور؟ قداش الإناث؟ حد عنده تفصيل؟ لأ والله ما حد
+
+474
+00:50:47,030 --> 00:50:51,370
+عنده تفصيل. إذا ما عنديش تفصيل بحطه بشكل يعني ده بقى
+
+475
+00:50:51,370 --> 00:50:57,090
+كنت لا أعلم إذا كان بشكل أكيد ذكر ولا أنثى، بحط
+
+476
+00:50:57,090 --> 00:51:06,330
+الواحد هذا الشكل في جيل معين، ماشي؟ إذا بحط أرقام
+
+477
+00:51:06,330 --> 00:51:13,650
+ماشي بهذا
+
+478
+00:51:13,650 --> 00:51:18,830
+الشكل هنا، number of children of six indicated، يعني
+
+479
+00:51:18,830 --> 00:51:23,330
+زي ما حكينا هنا مثلاً قبل شوية، واحد يقول جدة خالي
+
+480
+00:51:23,330 --> 00:51:29,690
+أبوي كان عندها خمسة، ثلاثة ذكور واثنين إناث، بهذا
+
+481
+00:51:29,690 --> 00:51:34,170
+الشكل. إذا حطّوا الرقم جوا على العكس هنا، واحد،
+
+482
+00:51:34,170 --> 00:51:39,390
+اثنين، ثلاثة، فهنا الشخص الأول، الشخص الثاني، الشخص
+
+483
+00:51:39,390 --> 00:51:43,970
+الثالث. الأول ولد، الثاني بنت، وبعدين بنت، بهذا
+
+484
+00:51:43,970 --> 00:51:47,990
+الترتيب هنا، number of children of six indicated،
+
+485
+00:51:47,990 --> 00:51:54,410
+يعني المجموع. الأب والأم هؤلاء مثلاً جابوا خمسة
+
+486
+00:51:54,410 --> 00:52:00,860
+ثلاثة ولاد وبنتين، هكذا. لما نحط اللون الأزرق، ماشي؟
+
+487
+00:52:00,860 --> 00:52:05,900
+فبمعناته affected، مصاب. segments filled for
+
+488
+00:52:05,900 --> 00:52:12,220
+different components of the phenotype. يعني أنا كنت
+
+489
+00:52:12,220 --> 00:52:19,460
+بعرف مثلاً أنثى حامل بهذا الشكل. إنسان أنا درسته
+
+490
+00:52:19,460 --> 00:52:25,060
+يعني مثلاً عنده الـgene اللي فلان، أنا عارف مثلاً
+
+491
+00:52:25,060 --> 00:52:30,520
+واحد عنده blood group أ، هو ممكن يكون AA، ممكن
+
+492
+00:52:30,520 --> 00:52:37,080
+يكون AO. فإذا أنا عارف أنه مثلاً AO، بحطه أنه نص A
+
+493
+00:52:37,080 --> 00:52:42,960
+ونص O مثلاً. يعني ده كنت بعرف Non-penetrant carrier،
+
+494
+00:52:42,960 --> 00:52:50,880
+may manifest disease. يعني هو أنا أحياناً نحكي
+
+495
+00:52:50,880 --> 00:52:54,440
+عن بعض الـ يعني بنحب أنه نظن أنه
+
+496
+00:52:57,770 --> 00:53:02,370
+الجينات والمادة الوراثية والصفات الوراثية، بنفكر
+
+497
+00:53:02,370 --> 00:53:05,090
+الأليل الـdominant والـrecessive. الـdominant
+
+498
+00:53:05,090 --> 00:53:10,070
+يعني بظهر، والـrecessive يعني متنحي وبتخبأ،
+
+499
+00:53:10,070 --> 00:53:15,530
+ما ببينش. بس الدنيا مش أبيض وأسود، مش فقط يا إما مصاب
+
+500
+00:53:15,530 --> 00:53:22,810
+يا إما غير مصاب أو سليم. أحياناً في درجة ظهور الحالة
+
+501
+00:53:22,810 --> 00:53:29,350
+الوراثية تتأثر بأشياء ثانية، يعني مثلاً الصُّلع جزء
+
+502
+00:53:29,350 --> 00:53:36,430
+منه فيه جين مسؤول عن الصُّلع وبيأثر. إذا الأنثى
+
+503
+00:53:36,430 --> 00:53:42,390
+عندها اثنين منه، آه بتبين، يعني فيه بيبين صُلع أكثر
+
+504
+00:53:42,390 --> 00:53:49,360
+على رأسها بشكل واضح. بينما في الأنثى لازم اثنين يكون
+
+505
+00:53:49,360 --> 00:53:54,340
+الجينات المسببة للصلع. بينما عند الرجال واحد بس
+
+506
+00:53:54,340 --> 00:53:58,380
+بيكفي، بيكون dominant وبتلاقي، بيبين صلع أكثر من
+
+507
+00:53:58,380 --> 00:54:03,080
+كثير. هي قضية اللي بيسموها الـPenetration of the
+
+508
+00:54:03,080 --> 00:54:08,880
+Character، يعني درجة قدرتها على الظهور. Obligate
+
+509
+00:54:08,880 --> 00:54:12,460
+carrier will not manifest disease. يعني ليه الحامل
+
+510
+00:54:12,460 --> 00:54:18,660
+للمرض أحياناً، يعني إحنا بنكون متأكدين أنه ظهر عند
+
+511
+00:54:18,660 --> 00:54:26,260
+إنسان مرض وكان نتيجة أنه موجود عند أبوه أو أمه، بس
+
+512
+00:54:26,260 --> 00:54:33,000
+كان الواحد منهم مش مصاب. بس يعني إذا ما كانت طفرة في
+
+513
+00:54:33,000 --> 00:54:37,680
+نفس الشخص، فلازم تكون في والده أو والدته، وبالتالي
+
+514
+00:54:37,680 --> 00:54:45,610
+نرسمها بهذا الشكل. إذا الشخص اللي بنتكلم عنه «موت»،
+
+515
+00:54:45,610 --> 00:54:51,370
+يعني متوفى، بنحط عليه خط بهذا الشكل. Spontaneous
+
+516
+00:54:51,370 --> 00:55:00,270
+abortion، يعني قضية إجهاض ذاتي، بيكون سواء مصاب أو
+
+517
+00:55:00,270 --> 00:55:07,310
+غير مصاب، طبعاً هو إجهاض مبكر، فبالتالي يعني في الأشهر
+
+518
+00:55:07,310 --> 00:55:12,530
+الأولى من الحمل ممكن ما يبين ذكر ولا أنثى، ماشي؟
+
+519
+00:55:12,530 --> 00:55:17,070
+بنرسمها بهذا الشكل. دكتور، في سؤال من كريم، بيسأل
+
+520
+00:55:17,070 --> 00:55:23,850
+شو في أمثلة على الـobligate carrier؟ لأ، أنت لما
+
+521
+00:55:23,850 --> 00:55:34,190
+تتكلم عن حالة مثلاً، نفترض، ناخد مرض Huntington's
+
+522
+00:55:34,190 --> 00:55:41,800
+Chorea، مثلاً، عبارة عن مرض «Autosomal Dominant»، فهو
+
+523
+00:55:41,800 --> 00:55:45,920
+سائد، بتلاقي
+
+524
+00:55:45,920 --> 00:55:49,800
+الإنسان
+
+525
+00:55:49,800 --> 00:55:56,720
+أنت شفته، مرض، يعني يعني
+
+526
+00:55:56,720 --> 00:56:01,340
+لما بدك تاخذه، لما تشوف إنسان مصاب فيه، أحياناً ممكن
+
+527
+00:56:01,340 --> 00:56:06,850
+يكون أنه هي طفرة اللي سببت المرض نشأت في هذا الشخص
+
+528
+00:56:06,850 --> 00:56:12,330
+وهو هينقلها لأولاده وبناته، ماشي؟ بس بيظل في
+
+529
+00:56:12,330 --> 00:56:18,350
+أحياناً احتمالية أنه كان موجود في أبوه أو أمه
+
+530
+00:56:18,350 --> 00:56:23,410
+وكانت Carrier، ولازم يكون Carrier. يعني إذا بتاخد
+
+531
+00:56:23,410 --> 00:56:27,890
+مثلاً في الـX-Chromosomes، مثلاً الـG6PD
+
+532
+00:56:27,890 --> 00:56:34,660
+Deficiency، جزء منه X-linked recessive، فالأم الأنثى
+
+533
+00:56:34,660 --> 00:56:40,100
+هي الحامل، لازم بشكل إجباري تكون هي الحامل حتى
+
+534
+00:56:40,100 --> 00:56:45,860
+تعطيه. يعني إذا واحد في مرض هو أخواله، اللي هو الـX
+
+535
+00:56:45,860 --> 00:56:53,320
+-linked chromosomes، بتلاقي معناته الأم الأنثى كانت
+
+536
+00:56:53,320 --> 00:56:57,340
+هي، ما بنقول عنها مصابة، بس لازم تكون حامل لأنه غير
+
+537
+00:56:57,340 --> 00:57:02,420
+هيك ما كان انتقل للطفل هذا. فاهم عليك كيف؟ يعني هي
+
+538
+00:57:02,420 --> 00:57:09,440
+الفكرة أن أنا بس الآن بدي آخذكم خلال الرموز هذه
+
+539
+00:57:09,440 --> 00:57:13,460
+حتى لما تشوفوها بعدين تفهموا شو معناها. يعني أنا
+
+540
+00:57:13,460 --> 00:57:17,680
+هذا الآن بحاول أُوجزه، ماشي؟ تفاصيل الأمور، راح
+
+541
+00:57:17,680 --> 00:57:21,920
+ناخد أمثلة كثيرة ونتكلم عنها، يصير الواحد يكون
+
+542
+00:57:21,920 --> 00:57:27,200
+مرتاح، ويحكي عن حاجة معينة، ماشي؟
+
+543
+00:57:29,990 --> 00:57:35,770
+الخط الثاني من فوق، Marriage أو Union، يعني زواج. لما
+
+544
+00:57:35,770 --> 00:57:40,810
+نحط ذكر وأنثى بهذا الشكل، إذا حطيت خطين بالنص هنا
+
+545
+00:57:40,810 --> 00:57:45,790
+يعني مطلقين. إذا حطيت Double Bond، يعني
+
+546
+00:57:45,790 --> 00:57:53,110
+Consanguinity، يعني زواج أقارب. ماشي؟ لما تحط أنه
+
+547
+00:57:53,110 --> 00:57:57,090
+مثلاً من العائلة هذه، الذكر والأنثى هذول مثلاً
+
+548
+00:57:57,650 --> 00:58:03,410
+تنزلّك خطين بهذا الشكل، وبينهم بعدين خط بالنص.
+
+549
+00:58:03,410 --> 00:58:08,010
+«monozygotic twins»، «monozygotic»، يعني توائم
+
+550
+00:58:08,010 --> 00:58:16,850
+متطابقة، فبتكون من نفس الجنس وبيكونوا متطابقين، نحطها
+
+551
+00:58:16,850 --> 00:58:22,900
+هكذا. إذا «dizygotic twins»، ممكن يكون واحد ذكر واحد
+
+552
+00:58:22,900 --> 00:58:27,520
+أنثى مثلاً، أو واحد ذكر واحد أنثى، أو اثنينهم إناث
+
+553
+00:58:27,520 --> 00:58:32,900
+أو اثنينهم ذكور، بيصير، بس بنحطها بهذا الشكل. يعني مش
+
+554
+00:58:32,900 --> 00:58:38,300
+زي الصورة هذه. هنا العائلة هذه مثلاً، الأب والأم
+
+555
+00:58:38,300 --> 00:58:42,860
+جابوا الطفل الأول ذكر، بعدين الطفل الثاني كانت أنثى،
+
+556
+00:58:42,860 --> 00:58:47,560
+يعني بهذا الشكل، جابوهم في حمل مختلف، فبنحط من نفس
+
+557
+00:58:47,560 --> 00:58:56,630
+المصدر، بيكون في نفس الحمل. ماشي؟ إذا كان فيه عدم ..
+
+558
+00:58:56,630 --> 00:59:04,150
+يعني عدم تأكد من نوعية الـZygote، يعني هل هو توائم
+
+559
+00:59:04,150 --> 00:59:08,330
+متطابقة أو غير متطابقة، الواحد بحط علامة استفهام،
+
+560
+00:59:08,330 --> 00:59:17,410
+إذا ما عنده يعني ثقة 100%. Stillbirth، اللي هو وفاة
+
+561
+00:59:17,410 --> 00:59:27,200
+في آخر الحمل، بحيث أنه يكون مبين ذكره أو أنثى، وبينحط
+
+562
+00:59:27,200 --> 00:59:34,200
+عليه علامة خط، ماشي؟ بهذا الشكل، still birth، وبكون
+
+563
+00:59:34,200 --> 00:59:40,500
+يعني وفاة في أواخر الحمل، بكون مرحلة متقدمة. adopted
+
+564
+00:59:40,500 --> 00:59:46,400
+into the family، بهذا الشكل، الحالة اللي هو التبني،
+
+565
+00:59:46,400 --> 00:59:52,260
+يعني شخص ماديته الوراثية مش من هذه العائلة، بس اتبنته
+
+566
+00:59:52,260 --> 00:59:58,080
+هذه العائلة. adopted out of the family، يعني حاطين
+
+567
+00:59:58,080 --> 01:00:06,620
+هنا الفروقات، شكل الخط اللي يعني حاطينه للعلاقة
+
+568
+01:00:06,620 --> 01:00:12,720
+العائلية هذه بهذا الإنسان، هنا ذكر. هنا انتهينا
+
+569
+01:00:12,720 --> 01:00:19,400
+الأمثلة. أخدت عائلة ثانية، وهنا العائلة أخذت بكر من
+
+570
+01:00:19,400 --> 01:00:28,060
+عائلة أخرى. pregnancy with information on details،
+
+571
+01:00:28,060 --> 01:00:33,700
+if available، يعني حالياً في حمل، بس إحنا مش عارفين
+
+572
+01:00:33,700 --> 01:00:42,730
+يعني لسه ما ولدت هي. last menstrual period، تاريخ أو
+
+573
+01:00:42,730 --> 01:00:47,730
+أنه حامل على أربعة وعشرين أسبوع من أربعين أسبوع
+
+574
+01:00:47,730 --> 01:00:53,070
+للحمل، تسعة أشهر، أو أن آخر يوم في الدورة في هذا
+
+575
+01:00:53,070 --> 01:00:57,550
+الحمل بتاريخ اثنين، عشرين، اثنا عشر، ألفين وأربعة عشر،
+
+576
+01:00:57,550 --> 01:01:02,570
+مثلاً. فإذا كان يعني عندنا details عن الـpregnancy،
+
+577
+01:01:02,570 --> 01:01:07,510
+بنحطها بهذا الشكل. الآن هذه بيسموها الـPedigree،
+
+578
+01:01:07,510 --> 01:01:14,300
+اللي هو اللي بيكون بهذا الشكل. لما نحط الـTimes
+
+579
+01:01:14,300 --> 01:01:19,100
+Roman، في هذا الشكل اللي هو الأجيال. هذا الجيل
+
+580
+01:01:19,100 --> 01:01:23,040
+الأول، هذا الجيل الثاني، هذا الجيل الثالث، الرابع،
+
+581
+01:01:23,040 --> 01:01:29,500
+قدر ما بدي. بحط الشخص الأول هنا، الجيل الأول مثلاً،
+
+582
+01:01:29,500 --> 01:01:34,950
+الذكر، وبعدين زوجته، وبعدين هنا الجيل الثاني، ذكر
+
+583
+01:01:34,950 --> 01:01:39,390
+ولد الأول، وبعدين البنت الثانية، والبنت الثالثة.
+
+584
+01:01:39,390 --> 01:01:44,610
+البنت الثانية هي المصابة. أحياناً الـproband،
+
+585
+01:01:44,610 --> 01:01:50,250
+اللي هو الشخص اللي خلانا نكتشف المشكلة في هذه
+
+586
+01:01:50,250 --> 01:01:54,010
+العائلة، أو خلانا ندرس هذا الموضوع في هذه العائلة.
+
+587
+01:01:54,010 --> 01:02:00,030
+يعني ممكن مثلاً أنا آجي إنسان مثلاً إندونيسي، يعمل له
+
+588
+01:02:00,030 --> 01:02:03,670
+الـBT والـBTT، ويشوف أن هي طالعة عنده هموفيليا،
+
+589
+01:02:04,110 --> 01:02:09,050
+الـHemophilia X-Linked Recessive، اكتشفتها هنا،
+
+590
+01:02:09,050 --> 01:02:13,230
+بعدين باجي بدقق في أهله، آه والله أخواله في عندهم
+
+591
+01:02:13,230 --> 01:02:17,870
+كان فيهم مشكلة معينة، بصير بعدين يطلع، وبعدين أخوال
+
+592
+01:02:17,870 --> 01:02:22,570
+أمه في بلد ثاني ما بعرفوش عنها، يمكن يكون شخص مصاب،
+
+593
+01:02:22,570 --> 01:02:28,450
+فكل ما يعني نكتشف أكثر، بنضيف أفراد وحالات، وشو
+
+594
+01:02:28,450 --> 01:02:34,770
+وضعم. ولما أنا أكون الشخص اللي بدأت في الاهتمام في
+
+595
+01:02:34,770 --> 01:02:38,710
+هذه القصة، بنسميه الـProband، اللي هو الشخص اللي
+
+596
+01:02:38,710 --> 01:02:45,770
+بدأنا فيه القصة. Arrow indicates consulted seeking
+
+597
+01:02:45,770 --> 01:02:53,520
+counseling. هنا راح نحكي مثلاً مثال. شغلات بتخوف، وبظل
+
+598
+01:02:53,520 --> 01:02:58,880
+الواحد لما تصير، يصير قلقان، بدي يفحص الجينات عشان
+
+599
+01:02:58,880 --> 01:03:05,580
+يشوف هل أنا مصاب؟ هل في احتمالية إصابتي؟ كم نسبة
+
+600
+01:03:05,580 --> 01:03:12,600
+لغيري؟ كذا كذا. إذا شخص لسه بده يعرف هل هو هيصاب أو
+
+601
+01:03:12,600 --> 01:03:18,060
+لا يصاب أو كذا، بنحطه سهم بهذا الشكل. إذا سهم على
+
+602
+01:03:18,060 --> 01:03:26,620
+يعني فراغ مُصمّت باللون الأزرق كامل بهذا الشكل، فهو
+
+603
+01:03:26,620 --> 01:03:31,080
+مصاب. وهنا الـProband، اللي هو يعني بدأت الدراسة
+
+604
+01:03:31,080 --> 01:03:38,430
+عليه. إذا هنا فهو شخص يأتي يستفتي عشان يسأل: هل أنا
+
+605
+01:03:38,430 --> 01:03:43,350
+سأصاب ولا لأ؟ بدي أعيش وأضغط، فبحطه على شكل بهذا
+
+606
+01:03:43,350 --> 01:03:49,110
+الشكل. إذا شخصين ما كان عندهم ذرية، no offspring،
+
+607
+01:03:49,110 --> 01:03:55,780
+بنحطها بهذا الشكل. وإذا واحد اتزوج زوجتين، فبتقول
+
+608
+01:03:55,780 --> 01:03:59,980
+الزوجة الأولى، وهذه الزوجة الثانية، نحطهم بهذا الشكل.
+
+609
+01:03:59,980 --> 01:04:08,820
+إذا صار إجهاض مش spontaneous، يعني إجهاض زي في دول
+
+610
+01:04:08,820 --> 01:04:13,870
+ثانية أو في أوضاع ثانية، بكون المرأة حقاً تجد حالها
+
+611
+01:04:13,870 --> 01:04:18,510
+فبتصير يعني إنه Termination of Pregnancy، بتبروها
+
+612
+01:04:18,510 --> 01:04:24,510
+في بعض المجتمع
+
+667
+01:10:12,200 --> 01:10:18,580
+Phenotype on RBCs يعني هذول الـ Antigens هذول
+
+668
+01:10:18,580 --> 01:10:24,040
+المظهر بتاع الإنسان هذا نتيجة هذه الجينات بهذا
+
+669
+01:10:24,040 --> 01:10:30,960
+الشكل لو جيت أنا أشوف الـ Anti-A والـ Anti-B اللي بحطه
+
+670
+01:10:30,960 --> 01:10:37,700
+لما قاعد أفحص الـ blood group، ماشي بحط نقطة
+
+671
+01:10:37,700 --> 01:10:42,420
+الـ Anti-A والـ Anti-B وبسوّي وبعدين بشوف هيك وعشان
+
+672
+01:10:42,420 --> 01:10:46,800
+أشوف فيه agglutination وبكون معناته positive،
+
+673
+01:10:46,800 --> 01:10:51,220
+فيه reaction، إذا مافيه reaction للإثنين، بكون O
+
+674
+01:10:51,220 --> 01:10:57,410
+إذا كانت reaction للـA بس، فهو A، جينياً يا AA
+
+675
+01:10:57,410 --> 01:11:03,250
+أو AO، إذا B بس، يعني B الـ Blood Group، يا BB
+
+676
+01:11:03,250 --> 01:11:10,730
+يا BO، إذا اشترك بالإثنين، بتكون AB، لهذا الشكل،
+
+677
+01:11:10,730 --> 01:11:20,830
+هذول بالـ Test، ماشي، بعد عمر السنة يعني الـ
+
+678
+01:11:20,830 --> 01:11:25,270
+Antigens للـ ABO Blood Group بتكون مش بس على الـ
+
+679
+01:11:25,270 --> 01:11:27,450
+Red Blood Cells، اللي أهم من الـ Red Blood Cells
+
+680
+01:11:27,450 --> 01:11:32,090
+موجودة على الـ Endothelium، موجودة على غشاء الطبقة
+
+681
+01:11:32,090 --> 01:11:37,030
+المبطنة للأوعية الدموية، فهي أهم من الـ Red Blood
+
+682
+01:11:37,030 --> 01:11:41,590
+Cells، بس طبعاً احنا اكتشفناهم على تأثيرهم على الـ
+
+683
+01:11:41,590 --> 01:11:49,280
+Red Blood Cells، فبعد عمر السنة بظهر في الإنسان بالـ
+
+684
+01:11:49,280 --> 01:11:53,780
+Antibodies اللي موجودة في الـ Serum، فاللي عنده AB
+
+685
+01:11:53,780 --> 01:11:58,480
+Blood Group ماعندوش أي نوع Antibodies ضد الـ A ولا
+
+686
+01:11:58,480 --> 01:12:04,200
+ضد الـ B، إذا عنده B Blood Group راح يتكون في جسمه
+
+687
+01:12:04,200 --> 01:12:09,480
+Anti-A، وإذا عنده Blood Group A بتكون الـ Anti-B
+
+688
+01:12:09,480 --> 01:12:15,850
+وإذا عنده O بيتكون Anti-A و Anti-B، طبعاً هذول
+
+689
+01:12:15,850 --> 01:12:20,310
+مبادئ أهميتهم أولاً في الـ Blood Transfusion، أمتى
+
+690
+01:12:20,310 --> 01:12:26,350
+بقدر أعطي دم الإنسان لإنسان، لازم مافي مجال أعطيه
+
+691
+01:12:26,350 --> 01:12:34,130
+كرات دم حمرا يكون في جسمه أجسام مضادة ضدهم، وبالتالي
+
+692
+01:12:34,130 --> 01:12:41,890
+تعمل reaction وتعمل مشكلة كبيرة كتير، أنا مضطر أن
+
+693
+01:12:41,890 --> 01:12:50,750
+أوقف هنا وبنكمل الأسبوع الجاي، في أسئلة؟
+
+694
+01:12:50,750 --> 01:12:57,850
+في أسئلة؟ إذا في أسئلة عندكم يا دكاترة، فيا ..
+
+695
+01:12:57,850 --> 01:13:01,670
+يعني يا بت .. بتسألوها أو بتبعتوها رسالة، رسالة
+
+696
+01:13:01,670 --> 01:13:06,170
+يعني نعم، نعم، ماشي
+
+697
+01:13:07,180 --> 01:13:12,860
+الله يوفقكم، وبعتذر اليوم يعني غير شكل، كان عندي
+
+698
+01:13:12,860 --> 01:13:17,820
+شغل إضافي، عارف هيك الحمد لله على كل حال، الله
+
+699
+01:13:17,820 --> 01:13:19,960
+يعطيك الخير يا دكتور، الله يعطيك الخير يا دكتور
+
+700
+01:13:19,960 --> 01:13:20,640
+الله يعطيك الخير يا دكتور، الله يعطيك الخير يا
+
+701
+01:13:20,640 --> 01:13:20,880
+دكتور، الله يعطيك الخير يا دكتور، الله يعطيك الخير
+
+702
+01:13:20,880 --> 01:13:20,900
+يا دكتور، الله يعطيك الخير يا دكتور، الله يعطيك
+
+703
+01:13:20,900 --> 01:13:21,160
+الخير يا دكتور، الله يعطيك الخير يا دكتور، الله
+
+704
+01:13:21,160 --> 01:13:22,880
+يعطيك الخير يا دكتور، الله يعطيك الخير يا دكتور
+
+705
+01:13:22,880 --> 01:13:24,160
+الله يعطيك الخير يا دكتور، الله يعطيك الخير يا
+
+706
+01:13:24,160 --> 01:13:25,560
+دكتور، الله يعطيك الخير يا دكتور، الله يعطيك الخير
+
+707
+01:13:25,560 --> 01:13:25,800
+يا دكت
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/KblmxBN0mak_postprocess.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/KblmxBN0mak_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..e42bb931cb648d2151ea86cab2fc69295e4ddf06
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/KblmxBN0mak_postprocess.srt
@@ -0,0 +1,2828 @@
+1
+00:00:00,930 --> 00:00:08,650
+خلّيني عشان أعمل share فيه
+
+2
+00:00:08,650 --> 00:00:15,430
+ابتدان، فيه أسئلة من المحاضرة
+
+3
+00:00:15,430 --> 00:00:25,890
+السابقة حد عنده أي ملاحظات يعني
+
+4
+00:00:25,890 --> 00:00:37,990
+احنا المحاضرة اللي فاتتبدأنا نحكي عن الأمثلة
+
+5
+00:00:37,990 --> 00:00:45,770
+الأقوى والأشد من أنواع الأمراض الوراثة وبكون إنه
+
+6
+00:00:45,770 --> 00:00:53,310
+قطعة كروموزوم كاملة أو جزء منها، قطعة كبيرةبتم إن
+
+7
+00:00:53,310 --> 00:00:59,150
+يكون فيها خلل سواء وعرفنا إنه ممكن تنحدث ممكن
+
+8
+00:00:59,150 --> 00:01:05,870
+تتكرر، تتزداد، تتقل، تتغير، كذا وإنه بدأنا نحكي عن
+
+9
+00:01:05,870 --> 00:01:13,970
+الأمثلة على هذا الموضوع في حد عنده أسئلة؟ أهم
+
+10
+00:01:13,970 --> 00:01:19,950
+ميكانزماللي هو Abnormal Chromosomal Segregation
+
+11
+00:01:19,950 --> 00:01:23,950
+اللي هي قضية الـNon-Disjunction يعني أنه لما كان
+
+12
+00:01:23,950 --> 00:01:28,190
+الكرومزومين جانب بعض لما ييجي في الـMetaphase في
+
+13
+00:01:28,190 --> 00:01:35,570
+قضية الـCell Division ينفصلوا لنصين متساويين بتكون
+
+14
+00:01:35,570 --> 00:01:40,270
+الإنقسام بشكل غير متساوي فالجهة بتكون فيها زيادة
+
+15
+00:01:40,270 --> 00:01:45,990
+وجهة بتكون فيها نقصان فهذا الـ… يعني هذه الظاهرة
+
+16
+00:01:48,480 --> 00:01:55,320
+يعني بالذات إذا حدثت وكانت فقط موجودة وبحيث أنه
+
+17
+00:01:55,320 --> 00:02:02,880
+بيقولها إنه كمية الـ DNA متوازنة في الشخص راح يكون
+
+18
+00:02:02,880 --> 00:02:07,800
+في الغالب ما إلها مشكلة عنده بقدر ما إنه في ذريته
+
+19
+00:02:07,800 --> 00:02:12,720
+في البروجينيت تبعه لما تحتاج هذه الخلايا تنقسم
+
+20
+00:02:12,720 --> 00:02:18,770
+برضه راح يصير فيها مشكلةوتكلمنا عن Trisomy 21 اللي
+
+21
+00:02:18,770 --> 00:02:24,390
+هو الـ Down Syndrome وحكينا ارتباطه بكبر عمر الأم
+
+22
+00:02:24,390 --> 00:02:30,470
+بالذات وكيف أحيانًا أنه بيكون عبارة عن حتى لما أجي
+
+23
+00:02:30,470 --> 00:02:38,230
+أعده كـ Trisomy 21 بلاقي لأ مافيش نسخة زايدة إنما
+
+24
+00:02:38,230 --> 00:02:45,340
+نسخة زايدة شابقة على كروموزوم 14فهي Translocation
+
+25
+00:02:45,340 --> 00:02:48,420
+من
+
+26
+00:02:48,420 --> 00:02:54,540
+الأمثلة على جزء
+
+27
+00:02:54,540 --> 00:03:01,220
+من الـ DNA اللي هي موضوع الـ Dijord Syndrome
+
+28
+00:03:01,730 --> 00:03:07,230
+بالنسبة للـ Die George Syndrome خلّينا نفرجيكم
+
+29
+00:03:07,230 --> 00:03:19,430
+الصورة هذه Die George Syndrome images
+
+30
+00:03:19,430 --> 00:03:25,370
+هذه
+
+31
+00:03:25,370 --> 00:03:28,410
+Save images
+
+32
+00:03:48,020 --> 00:03:55,700
+الـ Dijord Syndrome الـ
+
+33
+00:03:55,700 --> 00:03:59,900
+Dijord
+
+34
+00:03:59,900 --> 00:04:09,180
+Syndrome هو عبارة عنالـ Chromosome برضه 22 اللي هو
+
+35
+00:04:09,180 --> 00:04:19,760
+يعني الـ Chromosome 22 segment 11.2 إبارة عن قطعة
+
+36
+00:04:19,760 --> 00:04:29,790
+بتكون فيها اختلال فالـ Digort Syndromeحكينا نتيجة
+
+37
+00:04:29,790 --> 00:04:35,290
+اختلال هذه
+
+38
+00:04:35,290 --> 00:04:38,910
+القطعة بيصير خلل في الـ third و fourth pharyngeal
+
+39
+00:04:38,910 --> 00:04:44,470
+pouches تبعات الـ embryogenesis اللي هم المرحلة
+
+40
+00:04:44,470 --> 00:04:50,230
+المضغة في خلق الإنسان اللي هي محل ما كأنه قطعة
+
+41
+00:04:50,230 --> 00:04:53,690
+البان مأكولة هيك الإنسان بيكون في مرحلة معينة
+
+42
+00:04:54,160 --> 00:04:56,340
+الثالث والأربعاء هي الـ Pouches الفرنجية التي
+
+43
+00:04:56,340 --> 00:05:04,620
+تعطينا الـ Thymus وفيها تتم التطور والتكوين والـ T
+
+44
+00:05:04,620 --> 00:05:10,040
+-cells والمناعةالمتخصصة للخلوية فبالتالي بيصير
+
+45
+00:05:10,040 --> 00:05:14,020
+عندنا نقصان مناعة بيكون عندنا congenital heart
+
+46
+00:05:14,020 --> 00:05:17,840
+disease وبيكون عندنا hyperparathyroidism،
+
+47
+00:05:17,840 --> 00:05:20,960
+hypoparathyroidism وhypocalcemia لأن الـ
+
+48
+00:05:20,960 --> 00:05:25,140
+adrenaline الـ hypoparathyroid glands تطلع من الـ
+
+49
+00:05:25,140 --> 00:05:28,320
+third والfourth pharyngeal pouches فما بيكون عندهم
+
+50
+00:05:28,320 --> 00:05:35,880
+بالأخير الصورة هذه هي لطفل عندهده الـ Dijort
+
+51
+00:05:35,880 --> 00:05:42,280
+Syndrome أولاً، الذنين كما تشاهدون نزلت لأسفل
+
+52
+00:05:42,280 --> 00:05:49,500
+فبيسموها Lost Ears وIncreased Philtrum اللي هو
+
+53
+00:05:49,500 --> 00:05:57,500
+المسافة ما بين طرف الأنف وطرف الشفة بتلاقيها مسافة
+
+54
+00:05:57,500 --> 00:06:02,980
+طويلة وبيسموها Increased Philtrum وهي من المظاهر
+
+55
+00:06:02,980 --> 00:06:10,890
+اللي هيالـ Dijard Syndrome ممكن الواحد لما نيجي
+
+56
+00:06:10,890 --> 00:06:17,730
+يدور عليهم ده مش كرموزوم كامل باخد اللي بيسموه
+
+57
+00:06:17,730 --> 00:06:23,870
+Microarray و لا باخد الـ Fish اللي هو Fluorescence
+
+58
+00:06:23,870 --> 00:06:30,390
+in Cytohybridization يعني باخد الواحد عبارة عن
+
+59
+00:06:30,390 --> 00:06:40,160
+آلية حتى يدورعليها في الأمراض الأمراض الثانية ما
+
+60
+00:06:40,160 --> 00:06:44,080
+بدنا شيها بعدين
+
+61
+00:06:44,080 --> 00:06:49,900
+بدنا ندخل على six chromosomes وحكينا في الـ X والـ
+
+62
+00:06:49,900 --> 00:06:58,580
+Y chromosomes التعقيد مظهر الإنسان الجنسي كذكر أو
+
+63
+00:06:58,580 --> 00:07:08,350
+أنثى بتتم من خلال ثلاثمراحل المرحلة الأولى حكينا
+
+64
+00:07:08,350 --> 00:07:13,450
+عنها هي الـ Chromosomes وما هي الجينات اللي عندها
+
+65
+00:07:13,450 --> 00:07:21,130
+ومسؤول عن التحكم في أشياء معينة الجينات هذه والـ
+
+66
+00:07:21,130 --> 00:07:26,750
+Chromosomes الـ X والـ Y بتأثر على الأعضاء
+
+67
+00:07:26,750 --> 00:07:33,770
+التناسلية الـ Testicles والـ Ovariesوبتأثر عليها
+
+68
+00:07:33,770 --> 00:07:39,330
+في تطورها بيأثر عليها في وظيفتها بيأثر عليها في
+
+69
+00:07:39,330 --> 00:07:45,050
+قضية إفرازها للـHormones ونشاطها بشكل اللازم
+
+70
+00:07:45,050 --> 00:07:50,310
+والطبيعي بحيث إنه بالأخير بيعطينا المظهر الخارجي
+
+71
+00:07:50,310 --> 00:07:57,070
+لرجل أو امرأة ذكر أو أنثى بهذا الشكلالمرحلة
+
+72
+00:07:57,070 --> 00:08:04,710
+الأخيرة مهمة في تطور الجنس للإنسان قضية البيئة
+
+73
+00:08:04,710 --> 00:08:10,970
+اللي هو موجود فيها يعني قضية الترباية، قضية
+
+74
+00:08:10,970 --> 00:08:14,130
+التعليم
+
+75
+00:08:14,130 --> 00:08:19,180
+على سلوك معيندائماً بيقولوا يعني ولد صغير بتلاقي
+
+76
+00:08:19,180 --> 00:08:25,360
+وقع بعيط بيقولوا إيه؟ بتعيط؟ أنت زلمة، كيف اتعيط؟
+
+77
+00:08:25,360 --> 00:08:29,820
+ماصيرش اتعيط؟ كده يعني بتلاقيه بأثر عليه بشكل
+
+78
+00:08:29,820 --> 00:08:37,460
+بيخليه يتصرف بشكل معين فبالنسبة للتطور الجنسي
+
+79
+00:08:37,460 --> 00:08:45,020
+بالنسبة للـ X وY كرموزومات هذه ناحية مهمة كثيرةالـ
+
+80
+00:08:45,020 --> 00:08:48,780
+Y-Chromosome بشكل عام مافيش فيه عدد كبير من
+
+81
+00:08:48,780 --> 00:08:57,800
+الجينات يعني قطعة صغيرة وبتلاقي فيها يعني عدد قليل
+
+82
+00:08:57,800 --> 00:09:02,780
+من الـ من الجينات وحجمه صغير
+
+83
+00:09:06,840 --> 00:09:12,960
+التراكيب الجنسي عند الإبشر في الـ Embryogenesis
+
+84
+00:09:12,960 --> 00:09:20,860
+بتمر فترة بيكون عند الإنسان التراكيب مشتركة وبيكون
+
+85
+00:09:20,860 --> 00:09:26,520
+التراكيب ذكرية وأنثوية ففي بارة Mesonephric duct
+
+86
+00:09:26,520 --> 00:09:33,840
+وMesonephric ductوالـ Ambiguant أو Ambipotent
+
+87
+00:09:33,840 --> 00:09:41,860
+Guenade يعني هذه قصية أو مبيض مستعدة تكون أي نوع
+
+88
+00:09:41,860 --> 00:09:48,200
+وبتكون جاهزة أن تتوجه هيك أو تتوجه هيك فوهنا
+
+89
+00:09:48,200 --> 00:09:54,320
+التراكيب الجنسية الداخلية ترتبط بالتراكيب الجنسية
+
+90
+00:09:54,320 --> 00:10:03,040
+الخارجيةأهم عامل حتى يتم التوجيه باتجاه أن يكون
+
+91
+00:10:03,040 --> 00:10:10,080
+هناك ذكر هو وجود الـ Y-Chromosome وعدم وجوده يجعل
+
+92
+00:10:10,080 --> 00:10:15,980
+الأجهزة والـ Development تتوجه باتجاه الـ Female،
+
+93
+00:10:15,980 --> 00:10:21,090
+يعني هذه ناحية مهمةفإذا كان فيه Y-Chromosome بنتج
+
+94
+00:10:21,090 --> 00:10:26,070
+عنه أنه تتحول لقصية Testicles وSpermatogenesis
+
+95
+00:10:26,070 --> 00:10:31,090
+وفيه Androgens زي التستيرون وبعطينا الـ Male
+
+96
+00:10:31,090 --> 00:10:35,010
+Internal و External Genitalia وCharacteristics إذا
+
+97
+00:10:35,010 --> 00:10:40,370
+ما فيه، الأمور باتجاهنا تكون Female، فهذه ناحية
+
+98
+00:10:40,370 --> 00:10:41,070
+مهمة
+
+99
+00:10:44,550 --> 00:10:52,130
+بالنسبة لـ … يعني هناك اختلالات أوبتحدث دواهر
+
+100
+00:10:52,130 --> 00:10:59,990
+كثيرة في هذا الأمر ماشي بس النقطة المهمة أنه يعني
+
+101
+00:10:59,990 --> 00:11:03,890
+الأهم هو الـ X-Chromosome الـ X-Chromosome عليه
+
+102
+00:11:03,890 --> 00:11:09,970
+عدد كبير من الجينات مسؤول عنه كثير من التكون وفي
+
+103
+00:11:09,970 --> 00:11:17,230
+أشياء كثيرة عليه يعني يمكن 1500 جين يعني فبالنسبة
+
+104
+00:11:17,230 --> 00:11:24,210
+للـ X-Chromosomeشوما كان عدد النسخ تبع الـ X
+
+105
+00:11:24,210 --> 00:11:28,570
+-Chromosome واحد منها فقط هو الشغال الـ Active
+
+106
+00:11:28,570 --> 00:11:33,930
+بيكون راح يكون Active والبقية راح تكون نسميهم Par
+
+107
+00:11:33,930 --> 00:11:40,510
+Bodies وInactive وانا حاطين أمثلة إن هاي الـ
+
+108
+00:11:40,510 --> 00:11:46,210
+Normal Female أول واحدةاللي احنا شايفينه هو 46
+
+109
+00:11:46,210 --> 00:11:51,690
+كروموزوم زي ما نعمله كاريو تايب وكان XX فبهذا
+
+110
+00:11:51,690 --> 00:11:58,290
+الشكل فيه هناك بيسموها super female ممكن تلاقي شخص
+
+111
+00:11:58,290 --> 00:12:01,730
+أو أنثى عندها 47 كروموزوم
+
+112
+00:12:05,010 --> 00:12:09,610
+الأصليات اللي هم الأربعة واثنين وعشرين pair زائد
+
+113
+00:12:09,610 --> 00:12:18,230
+XXX أو XXXX أو XX يعني حتى أربع نسخة من inactive
+
+114
+00:12:18,230 --> 00:12:27,170
+form of X-chromosome فلو كان مثلًافي الـ Male
+
+115
+00:12:27,170 --> 00:12:31,850
+مظهريًا اللي بيسموه «تيرنر سندروم» بتلاقوا عندها
+
+116
+00:12:31,850 --> 00:12:38,250
+45XO الـ O يعني مافيش عندها نسخة ثانية فبلاقي لما
+
+117
+00:12:38,250 --> 00:12:44,230
+نعمل دراسة بهذا الشكل كـ Karyotype أو عشان ندور
+
+118
+00:12:44,230 --> 00:12:48,430
+على الـ Inactive X-Chromosome نلاقي فيه صفر، مافيش
+
+119
+00:12:48,430 --> 00:12:54,110
+فيه نفس الظاهرة ممكن تحدث في الـ Males عادةً الـ
+
+120
+00:12:54,110 --> 00:13:00,710
+Male أهم جانببشكل طبيعي أنه وجود الـ Y ما ندخل عدد
+
+121
+00:13:00,710 --> 00:13:13,330
+نسخ الـ X ماشي في أسئلة هنا بقولكم بالنسبة لنتوقع
+
+122
+00:13:13,330 --> 00:13:20,710
+يعني كيف بالنسبة لغربية الـ Females راح نلاقي أنه
+
+123
+00:13:21,290 --> 00:13:28,770
+في كل خلية أو مجموعة خلايا بتلاقي أحد نسختين الـ X
+
+124
+00:13:28,770 --> 00:13:33,850
+-Chromosome inactive يا إما الـ X اللي جاي من الأب
+
+125
+00:13:33,850 --> 00:13:39,790
+أو الـ X اللي جاي من الأم فهي يعني أحياناً بتأثر
+
+126
+00:13:39,790 --> 00:13:49,260
+على يعني إذا مثلاً في مرض عند الأبوبتلاقي أو
+
+127
+00:13:49,260 --> 00:13:55,960
+بالعكس يعني مثلًا هناك أنثى حامل لـ Chromosome لـ
+
+128
+00:13:55,960 --> 00:14:00,760
+Gene على الـ X-Chromosome وفيه مرض فإيه الأصل؟
+
+129
+00:14:00,760 --> 00:14:04,880
+بنقول هي حامل وغير مصابة غير مصابة يعني مافيش
+
+130
+00:14:04,880 --> 00:14:10,990
+عندها مشكلةوبكون إذا كان عندها مظهر، بعض مظاهر
+
+131
+00:14:10,990 --> 00:14:15,750
+المشكلة بيكون إنه هاي في الخلايا اللي إن النسخة
+
+132
+00:14:15,750 --> 00:14:19,010
+المضروبة من الـ X هي اللي فاعلة أو هي اللي active
+
+133
+00:14:19,010 --> 00:14:27,370
+فهي أحيانًا ظاهرة بتحدث فيها سؤالة؟
+
+134
+00:14:27,370 --> 00:14:33,070
+الآن بالنسبة
+
+135
+00:14:33,070 --> 00:14:40,310
+للأمراض والمشاكلاللي هي فيه Abnormalities في الـ
+
+136
+00:14:40,310 --> 00:14:44,390
+Sex Chromosome يعني الـ Whole Chromosome Anomaly
+
+137
+00:14:44,390 --> 00:14:50,190
+ففيه مرض اسمه Client Filter البقية بدناشي يعني
+
+138
+00:14:50,190 --> 00:15:03,130
+ناشي ال .. ال .. بالنسبة لـ Client Filterبتلاقي 47
+
+139
+00:15:03,130 --> 00:15:06,690
+كروموزومز
+
+140
+00:15:06,690 --> 00:15:14,170
+الـ Total موجود و44 أو 22 زوج أوتوزامل وبعدين الـ
+
+141
+00:15:14,170 --> 00:15:20,750
+6 كروموزومز في XXY، ماشي؟ هذه تقريبًا واحد في كل
+
+142
+00:15:20,750 --> 00:15:29,330
+600 ذكر حوالي تقريبًا في أحدكم بعتليسؤال، نحفظ
+
+143
+00:15:29,330 --> 00:15:33,430
+الأرقام هذه؟ أنا بقول ما في داعي الواحد يحفظها
+
+144
+00:15:33,430 --> 00:15:39,330
+بقدر ما أنه يعني ينتبه لعلاقاتهم مع بعض اللي هي
+
+145
+00:15:39,330 --> 00:15:46,350
+قضية أنه مثلا أشع مرض اللي هو Climfilter، ماشي؟
+
+146
+00:15:46,350 --> 00:15:52,350
+حوالي واحد في ستمية، ماشي؟ بالـFemales أكثر أشع
+
+147
+00:15:52,350 --> 00:15:57,550
+يشيل هو الـTurner واحد في كل أربع تلاف، ماشي؟
+
+148
+00:15:57,940 --> 00:16:02,000
+فأحيانًا إنك تشوف رقم واحد هيك تنتبهين إن هو رقم
+
+149
+00:16:02,000 --> 00:16:07,960
+واحد ناحية مهمة دكتور في سؤال كريم يتكلم عن الـ
+
+150
+00:16:07,960 --> 00:16:11,800
+Inactivation للـ X بيسأل كيف بيصير، يعني بيسأل عن
+
+151
+00:16:11,800 --> 00:16:17,970
+الـ Mechanismالمطلوب زي ما شُفت في النسخ اللي فيها
+
+152
+00:16:17,970 --> 00:16:25,470
+Bar Bodies إنه في أي خلية واحد من الـ X
+
+153
+00:16:25,470 --> 00:16:31,250
+-Chromosomes هو اللي وحيد اللي شغّال، فبالظبط كيف
+
+154
+00:16:31,250 --> 00:16:37,730
+بحدث؟ ليش بحدث بهذه الطريقة؟ يعني ما، ماعندي يعني
+
+155
+00:16:37,730 --> 00:16:43,510
+تفسير، بقدر ما إنها هي هيك بتحدث هيك ربنا حاططها
+
+156
+00:16:43,510 --> 00:16:54,020
+فينافالآن هذولة أربع إناث ماشي لما نيجي وحاطين هنا
+
+157
+00:16:54,020 --> 00:17:01,260
+صورة لبعدين التوزيع يعني كام لو جبت ألف أنثى أو
+
+158
+00:17:01,260 --> 00:17:06,980
+درست الـ X-Chromosomes تبعينهم حلاق الغالبي العظمى
+
+159
+00:17:06,980 --> 00:17:16,860
+XX وامور تيادية بشكل يعتبرعشوائي، راندوم، يعني مش
+
+160
+00:17:16,860 --> 00:17:22,760
+إشي مقفود، هيك يظن يعني، ماشي الغالبية العظمى راح
+
+161
+00:17:22,760 --> 00:17:29,900
+تلاقوا إنه في واحد فقط من النسخ تبعات الـ X هي
+
+162
+00:17:29,900 --> 00:17:37,720
+النشطة هي الـ Euchromatin بسموها، يعني هي اللي طبة
+
+163
+00:17:37,720 --> 00:17:45,540
+الحبل أو الخيط تبع الـ DNAبدل ما هو مضغوط وقت الـ
+
+164
+00:17:45,540 --> 00:17:50,480
+Cell Division لأ، بيكون فايلت عشان يتم قراءة
+
+165
+00:17:50,480 --> 00:17:56,240
+الجينات اللي عليه فهذا راح يكون نسخة واحدة بس هي
+
+166
+00:17:56,240 --> 00:18:03,870
+شغالة بهذه الطريقة البقية بتكون Inactiveفحسب إذا
+
+167
+00:18:03,870 --> 00:18:08,950
+كانت هذه الـ Normal Female اللي هي الـ XX بتلاقي
+
+168
+00:18:08,950 --> 00:18:15,530
+بتشوف هيكي واحد Bar Body اللي هو شو اسمه اللي هو
+
+169
+00:18:15,530 --> 00:18:22,390
+Inactive X-Chromosome إذا عندها XXX بتكون واحد
+
+170
+00:18:22,390 --> 00:18:29,270
+Active واثنين Inactive إذا XXXX أربع نسخواحد
+
+171
+00:18:29,270 --> 00:18:34,590
+«active» وثلاثة «inactive» بالشكل هذا لأن لماذا
+
+172
+00:18:34,590 --> 00:18:42,670
+بالضبط هكذا تحصل؟ أنا ماعرف، ماعندي تفسير بشكل
+
+173
+00:18:42,670 --> 00:18:48,530
+مقنع لماذا هذه الظاهرة تحصل هكذاالنوعية الجينات
+
+174
+00:18:48,530 --> 00:18:55,430
+اللي بنحتاجها، إذا في آليات أخرى، يعني زي تبعات
+
+175
+00:18:55,430 --> 00:18:59,050
+الـ Immunoglobulins، Allelic Exclusion، إذا واحد
+
+176
+00:18:59,050 --> 00:19:04,530
+اشتغل، هو بيسكر على الثاني، ما بعرف، ماشي؟ بس هذه
+
+177
+00:19:04,530 --> 00:19:08,410
+الظاهرة هيك بتصير، يعني هي النقطة اللي بدك تاخدها،
+
+178
+00:19:08,410 --> 00:19:16,330
+ماشي؟في سؤال من أسماء تتكلم بتقول المحاضرة السابقة
+
+179
+00:19:16,330 --> 00:19:21,370
+ذكرت لدكتور أنه ممكن نميز المرأة عن الرجل عن طريق
+
+180
+00:19:21,370 --> 00:19:27,030
+الـ bar body لعدم وجودها في الرجل ولكن تم تصنيف
+
+181
+00:19:27,030 --> 00:19:33,850
+مرض Turner على أنه أنثى رغم عدم احتواء على الـ bar
+
+182
+00:19:33,850 --> 00:19:36,970
+body فكيف هذه النقطة؟ مش عارف إذا جريت السؤال صح
+
+183
+00:19:36,970 --> 00:19:41,770
+يا أسماء أو لايعني هي بتسأل أنه الـ bar body هو
+
+184
+00:19:41,770 --> 00:19:47,110
+اللي كان بيميز المرأة عن الراجل؟ لأ لأ لأ مش ما
+
+185
+00:19:47,110 --> 00:19:54,530
+قلت هيك أو مش هاي المظبوط افهم الشغل أسس التراكيب
+
+186
+00:19:54,530 --> 00:20:04,000
+الجنسية سواء الخارجيةقناة «مجرال بول» كيف الأعضاء
+
+187
+00:20:04,000 --> 00:20:12,420
+التناثلية الخصيطين المبايض بشكل استدى كذا كذا هذه
+
+188
+00:20:12,420 --> 00:20:20,600
+الظواهر وهذه الأشياء بدرجة أساسية تكون مرتبطة مع
+
+189
+00:20:20,600 --> 00:20:25,080
+وجود أو عدم وجود الـY-Chromosome دعوني أتفق على
+
+190
+00:20:25,080 --> 00:20:31,560
+ناحية هذهلما تشوفي Turner ماشي، انت بتحطه صور
+
+191
+00:20:31,560 --> 00:20:36,420
+الـTurner هسه أنا صور بعض الأشياء اللي موجودة لهذه
+
+192
+00:20:36,420 --> 00:20:42,000
+الأشياء يعني محرج شويه، ماحطيتش صورها بس طلع عليها
+
+193
+00:20:42,000 --> 00:20:51,940
+في الكتاب منظر الـTurner هي أنثى قصيرة المظاهر
+
+194
+00:20:51,940 --> 00:20:57,830
+الأنوث عليها مش peer قويةوفيه على الرقب بتحس
+
+195
+00:20:57,830 --> 00:21:04,350
+بيسموها يعني Web اللي هو يعني حوالين الرقب يلهم
+
+196
+00:21:04,350 --> 00:21:10,470
+مظهر مميز فالآن بس بالأخير يعني شكل الأعضاء
+
+197
+00:21:10,470 --> 00:21:15,370
+التناسلية بتقول هي أنفة ما بتقول عنها رجل فاهم
+
+198
+00:21:15,370 --> 00:21:21,050
+علي؟ فالآن إذا
+
+199
+00:21:21,050 --> 00:21:29,490
+افترضنا الإنسانضمن مجموعة وأظن إنه يعني هو جزء من
+
+200
+00:21:29,490 --> 00:21:33,970
+الطبيعي يعني مش يعني صحيح ممكن بعض الناس يكون عنده
+
+201
+00:21:33,970 --> 00:21:40,790
+مختلال بس بيكون نخترض إنسان طبيعي ولغرض ما زي
+
+202
+00:21:40,790 --> 00:21:48,730
+تيرنر آجي أنا بعمل الـ الـ الـ Bar Buddy مثلا راح
+
+203
+00:21:48,730 --> 00:21:53,540
+ألاقي إنه فعلا مافيش Bar Buddyهو أقرب للذكورة، بس
+
+204
+00:21:53,540 --> 00:21:57,840
+الذكورة أهم شي بميزة وجود الـY الـY مش موجود، مش
+
+205
+00:21:57,840 --> 00:22:05,400
+يعني، مدام الـY مش موجود، ماشي، راح تتحول الأليات
+
+206
+00:22:05,400 --> 00:22:10,900
+كلها باتجاه الأنثى، هيك بيكون، ماشي، فليش تيرنر
+
+207
+00:22:10,900 --> 00:22:16,500
+أنثى؟ لأنه مافيش Y، هذا باختصار، بس مش أنثى طبيعية
+
+208
+00:22:16,500 --> 00:22:24,050
+لأنه ماعنداش XX اللي هو متوقعبتكون XO ماشي وفيه
+
+209
+00:22:24,050 --> 00:22:31,210
+Super Female بتلاقي XXX مثلا وش اسمه؟ وفيه يعني
+
+210
+00:22:31,210 --> 00:22:37,690
+هدولة بشكل عام يعني واضح؟
+
+211
+00:22:37,690 --> 00:22:47,300
+آخر يعني مع النقطة اللي بدنا نحكيهااللي هي
+
+212
+00:22:47,300 --> 00:22:54,380
+Androgen Insensitivity Syndrome أو اللي هنا حاطينا
+
+213
+00:22:54,380 --> 00:23:00,120
+بالـ Female بالنسبة للـ XY فأحنا يعني أنا اللي
+
+214
+00:23:00,120 --> 00:23:04,420
+شرحته قبل شوية كل الكلام على إنه إذا الـ Y موجود
+
+215
+00:23:04,420 --> 00:23:10,960
+فالغالب راح يشتغل إنه يكون يطلع بشكل ذكر، ماشي؟
+
+216
+00:23:10,960 --> 00:23:17,980
+بالنسبة للمن يكون أحيانًاالـ Y كمان موجود بس
+
+217
+00:23:17,980 --> 00:23:22,720
+مظهريًا بتبين أنت ماشي، هذا بيسموه تفتكلر
+
+218
+00:23:22,720 --> 00:23:27,120
+-feminization syndrome أحيانًا إلها اسم زي هيته أو
+
+219
+00:23:27,120 --> 00:23:32,740
+الـ Androgen Insensitivity Syndrome الوصف لهذا
+
+220
+00:23:32,740 --> 00:23:42,140
+الإنسان، ماشي، بيكون إنه أولًا عنده خصية، ماعندهوش
+
+221
+00:23:42,140 --> 00:23:50,040
+مبايظيعني بتكون التراكيب الجنسية الداخلية ذكر
+
+222
+00:23:50,040 --> 00:23:56,340
+بيكون عنده خصية بيكون الخصية بتشتغل، بتطلع
+
+223
+00:23:56,340 --> 00:24:03,480
+الـAndrogen بس وظيفة الهرمونات الذكرية غير فاعلة
+
+224
+00:24:03,480 --> 00:24:12,820
+ففي هذا المظهر بتلاقيها مظهريًا بتبين أنثى يعني
+
+225
+00:24:12,820 --> 00:24:20,430
+الأداءالمجلة الـ bowling خارجي ماشي بيكون على شكل
+
+226
+00:24:20,430 --> 00:24:28,950
+أنثى و .. بس من جوا الـ gonads والتراكيب الداخلية
+
+227
+00:24:28,950 --> 00:24:36,930
+يعني ما عندها رحمة ما عندها مضايض بتلاقي موجود شو
+
+228
+00:24:36,930 --> 00:24:46,920
+اسمه اللي هو خصية جوا وتراكيب ثانية ومشبس التراكيب
+
+229
+00:24:46,920 --> 00:24:52,760
+الخارجي المهبل بتلاقيه موجود وهدولة ميزتهم يعني
+
+230
+00:24:52,760 --> 00:24:59,140
+حتى لو واحد يتذكر هذه الحالة بتقول إن الشعر في
+
+231
+00:24:59,140 --> 00:25:08,620
+منطقة العاني والإبط مش موجود هدولة يعني حالة خاصة
+
+232
+00:25:08,620 --> 00:25:15,330
+بيقول فيها Y-Chromosomeبس مش شغال كأنه مش موجود
+
+233
+00:25:15,330 --> 00:25:21,630
+وبشبه نظرياً الـ Female بتكون الأمور مخربطة، ماشي؟
+
+234
+00:25:21,630 --> 00:25:27,300
+فهدولة الحالة اللي بنعتبرها ثالثةبشكل عام الـ Clam
+
+235
+00:25:27,300 --> 00:25:31,780
+Filter والـ Turner اذكروهم طبعاً Super Female أو
+
+236
+00:25:31,780 --> 00:25:40,360
+XXY بيكون اللي هو XXY Clam Filter أو أكثر XXXY أو
+
+237
+00:25:40,360 --> 00:25:46,580
+غيره، ماشي وفي اللي هو الـ Androgen Insensitivity
+
+238
+00:25:46,580 --> 00:25:52,260
+Syndrome اللي هو بيكون نوعية ثالثةبيكون صح الـ Y
+
+239
+00:25:52,260 --> 00:25:56,720
+موجود بس مش شغال كأنه مش موجود وبالتالي فبتطلع
+
+240
+00:25:56,720 --> 00:25:57,720
+الأمور مقربة
+
+241
+00:26:05,730 --> 00:26:15,210
+هنا تفاصيل أكثر عن إيش يعني الـ «Climb Filter»
+
+242
+00:26:15,210 --> 00:26:19,910
+حكينا تقريباً هو أشعة واحد ألف وواحد على ستمية
+
+243
+00:26:19,910 --> 00:26:29,120
+بكون طول ماليعني هنا الـ… بيكونوا في عندهم مشاكل
+
+244
+00:26:29,120 --> 00:26:33,600
+في الخلف وما بيستطيع يعني فيه Hypogonadism
+
+245
+00:26:33,600 --> 00:26:38,420
+أزوسبيرميا، Infertility وبيكونوا في عندهم مشاكل
+
+246
+00:26:38,420 --> 00:26:46,180
+الـXYY بالنسبة للـSex Development طبيعي برضه Tall
+
+247
+00:26:46,180 --> 00:26:49,860
+Male يعني
+
+248
+00:26:49,860 --> 00:26:56,170
+هو بيحاولوا الـيعطوكم المظاهر
+
+249
+00:26:56,170 --> 00:27:02,690
+تبعيتهم وبالنسبة للـ Turner اللي هو الواحد في كل
+
+250
+00:27:02,690 --> 00:27:08,670
+أربع تلاف تقريبًا بـ Short Stature بيكون قصيرة في
+
+251
+00:27:08,670 --> 00:27:15,070
+الـ Web Neck اللي هو حكيمة على الرقبة بيكون زي
+
+252
+00:27:15,070 --> 00:27:21,620
+الغشاء هيكعلى جانب طالع Risk of Cardiac Anomalies
+
+253
+00:27:21,620 --> 00:27:30,020
+عادة الـ Mental ممكن Typically Normal بس أحياناً
+
+254
+00:27:30,020 --> 00:27:36,690
+بيكون فيه Retardation شويةأو الـ Impaired Social
+
+255
+00:27:36,690 --> 00:27:43,050
+Adjustments يعني هون الأمثلة على الأمراض الأساسية
+
+256
+00:27:43,050 --> 00:27:48,250
+تبعات الـ X-Chromosome Abnormalities أو الـ Sex
+
+257
+00:27:48,250 --> 00:27:53,050
+Chromosome Anomalies، ماشي، قاسي الأخرى؟
+
+258
+00:27:58,010 --> 00:28:07,450
+الأن تكرار تفاصيل الجينات المسؤولة عن تكوين الخصي
+
+259
+00:28:07,450 --> 00:28:12,690
+والبربخ والقناة مجرى البول بالشكل هذا عند الذكور
+
+260
+00:28:12,690 --> 00:28:26,440
+وعند الإناث وكذا، بدناشي يعنيماشي، تفاصيل التعقيد
+
+261
+00:28:26,440 --> 00:28:34,420
+الأكثر من الـ Sex chromosomes وبعدين
+
+262
+00:28:34,420 --> 00:28:38,640
+الجينات اللي على الـ Sex chromosomes وكيف تتحكم في
+
+263
+00:28:38,640 --> 00:28:43,830
+أن المظهر يكون بالشكل هذااللي راح فيه عندنا حالة
+
+264
+00:28:43,830 --> 00:28:49,130
+يعني إذا بتعرفوها «precocious pre-puberty» يعني
+
+265
+00:28:49,130 --> 00:28:55,850
+البلوغ المبكر بتلاقي أنثى أو ذكر طبعاً بالأول
+
+266
+00:28:55,850 --> 00:29:02,900
+الإنسان يعنيبيولد بطوله حجم معين بتلاقي المرحلة
+
+267
+00:29:02,900 --> 00:29:09,720
+الطفولة بتلاقي الإنسان ماعلوش مظاهر جنسية نموه
+
+268
+00:29:09,720 --> 00:29:14,620
+بشكل عام بعد أول سنة بيصير يبطأ يبطأ لحد ما تيجي
+
+269
+00:29:14,620 --> 00:29:21,180
+فترة الغلوغ وبعدين بتلاقي نموه بشد بشكل كبير فاللي
+
+270
+00:29:21,180 --> 00:29:30,010
+عنده غلوغ مبكر ماشي بتلاقي أولاًأولها بيتلاقي فترة
+
+271
+00:29:30,010 --> 00:29:34,950
+وارتفعة بشكل كبير وصار النمو عنده في الطول وفي
+
+272
+00:29:34,950 --> 00:29:40,810
+المظاهر كبير بس بعدين في المحصلة النهائية راح تكون
+
+273
+00:29:40,810 --> 00:29:46,150
+إنه لأ راح يطلع طوله أقصر من غيره اللي بتأخره بس
+
+274
+00:29:46,150 --> 00:29:51,170
+بيظلوا مدة أكبر وهو ينمو فهذه المظاهر بتأثر على
+
+275
+00:29:51,170 --> 00:29:55,860
+أشياء كثيرة وبالأخير يعني كمان نحكي إنهغير هذه
+
+276
+00:29:55,860 --> 00:29:59,620
+الأمور كعوامل
+
+277
+00:29:59,620 --> 00:30:06,420
+تأثير على نمو وتطور الإنسان الجنسيكما تتدخل فيها
+
+278
+00:30:06,420 --> 00:30:13,620
+الجوانب الإجتماعي والمجتمعية وتعامل المجتمع معاه
+
+279
+00:30:13,620 --> 00:30:23,500
+وتقبل الناس إليه كشخص واضح حتى
+
+280
+00:30:23,500 --> 00:30:30,660
+في الشارع يوجد مباحث معينة تقولالخمسة يعني شخص
+
+281
+00:30:30,660 --> 00:30:36,540
+أعضاءه مش مبينة هي ذكر ولا أنثى، هذه أه و الله
+
+282
+00:30:36,540 --> 00:30:41,420
+بتحدث و أحياناً في ناس هيكي و كيف ده بتتعامل معاه،
+
+283
+00:30:41,420 --> 00:30:47,860
+فيه له جانب في الطبلأطباء يعني الغدد الصماء
+
+284
+00:30:47,860 --> 00:30:52,600
+بتدخلوا فيها أطباء المسالك البولية أو أطباء
+
+285
+00:30:52,600 --> 00:31:01,300
+النسائية بتلاقي يعني فيه تخصصات في الطببيدرسوا
+
+286
+00:31:01,300 --> 00:31:07,720
+يعني كيفية يعني فيه اللي بيسموه true hermaphrodite
+
+287
+00:31:07,720 --> 00:31:13,020
+true hermaphrodite اللي هو يعني الخنثة الحقيقية
+
+288
+00:31:13,020 --> 00:31:21,480
+بتلاقي شخص عنده خصية و مثلا قضيب و ذكر و يحيط
+
+289
+00:31:21,480 --> 00:31:26,640
+فهناك رحم حقيقي الداخل في حيث أنه بتصير دورة شهرية
+
+290
+00:31:26,640 --> 00:31:32,320
+و بنزل الدمبتلاقي أحيانًا يعني أشخاص عندهم
+
+291
+00:31:32,320 --> 00:31:40,040
+إبتلاءات وأمراض بتكون إنه التطور الجنسي غير كامل
+
+292
+00:31:40,040 --> 00:31:45,920
+غير واضح، غير سليم، يعني هناك إشكالية فيها فهذه
+
+293
+00:31:45,920 --> 00:31:49,180
+جوانب
+
+294
+00:31:49,180 --> 00:31:57,310
+يعني خلّيني على الأمثلة الكبيرةيعني اللي حطناها
+
+295
+00:31:57,310 --> 00:32:04,290
+قبل شوية وخلّينا الأمثل الكبير ونفهم تداخلها ما
+
+296
+00:32:04,290 --> 00:32:11,510
+بين أولاً كروموزومات لجينات لهرمونات لتراكيب بعد
+
+297
+00:32:11,510 --> 00:32:20,430
+ذلك تدخل في قضية يعني كيف المجتمع يتعامل مع هذا
+
+298
+00:32:20,430 --> 00:32:27,990
+الموضوعيعني إذا التراكيب البولية الخارجية مش واضحة
+
+299
+00:32:27,990 --> 00:32:33,810
+أحيانًا بتضطر على حتى عمر صغير أحيانًا الجراح
+
+300
+00:32:33,810 --> 00:32:38,410
+بتضطر يدخل ويعدل ويظبط وكذا إذا مثلًا فيه
+
+301
+00:32:38,410 --> 00:32:45,500
+hypospadias بتكون فتحة قناة Magical Ballعند الولد
+
+302
+00:32:45,500 --> 00:32:53,880
+يعني فيها مشكلة و بتلاقي الجراح مثلا بدخل بظبطها ب
+
+303
+00:32:53,880 --> 00:32:58,420
+.. ب .. ب .. في عمليات طبعاً تسمعوا عنها للناس
+
+304
+00:32:58,420 --> 00:33:02,960
+أحياناً نتيجة هذه المشكلة بيصير عنده مرض نفسي ومش
+
+305
+00:33:02,960 --> 00:33:07,100
+عارف حاله ولد ولا بنت، ذكر ولا أمثة ويصير يطلب
+
+306
+00:33:07,100 --> 00:33:16,800
+يغيروا جنسه يعني هذه أشياءيعني صحيح المجتمعات اللي
+
+307
+00:33:16,800 --> 00:33:23,200
+أدخل فيها أحيانًا ولكن أيضًا الـ يعني في أحيانًا
+
+308
+00:33:23,200 --> 00:33:31,700
+بشر عندهم مرض وبكون ما بين يعني هرموناته،
+
+309
+00:33:31,700 --> 00:33:38,760
+جيناته، روموزوماته بتكون الأمور مختلفة زائد تأثير
+
+310
+00:33:38,760 --> 00:33:43,390
+المجتمع يعني كيف الأهلبيربوا الولد أو بيربوا البنت
+
+311
+00:33:43,390 --> 00:33:47,770
+يعني البنت بيجيبولها لعاب بيلبسوها بشكل حلو
+
+312
+00:33:47,770 --> 00:33:53,070
+بيهتموا فيها بطريقة مختلفة اللعبة اللي بتكون وكذا
+
+313
+00:33:53,070 --> 00:33:57,970
+أحياناً هي بتأثر نفسية على حتى تطور الإنسان بعد
+
+314
+00:33:57,970 --> 00:34:06,830
+ذلك فلحد هنا هاي اللي هي المواضيع اللي يعني
+
+315
+00:34:09,650 --> 00:34:14,250
+المواضيع اللي بنعتبر كانت
+
+316
+00:34:14,250 --> 00:34:18,430
+في قضية الـ
+
+317
+00:34:18,430 --> 00:34:23,510
+«Closed Zone»؟ لأ، خلّيني أشوف، أسسا ندخل على
+
+318
+00:34:23,510 --> 00:34:31,990
+المحاضرة التالية في أسئلة؟ في حد في عنده صعوبة في
+
+319
+00:34:31,990 --> 00:34:35,330
+شغله؟ «Genetics»؟
+
+320
+00:34:38,950 --> 00:34:54,170
+عشان أفتح المحاضرة اللي بعدها هسا
+
+321
+00:34:54,170 --> 00:35:04,130
+المجموعة اللي بعدها إحنا خلصنا أكبر أو المجموعة
+
+322
+00:35:04,130 --> 00:35:11,360
+اللي مميز إلها كثرتالمظاهر المرضية بسبب أنه عدد
+
+323
+00:35:11,360 --> 00:35:18,260
+الجينات المشتركة في قضية الاختلال نتيجة أن
+
+324
+00:35:18,260 --> 00:35:22,600
+الكروموزوم كله فيه إشي غلط فراح ينتج عنه عادة
+
+325
+00:35:22,600 --> 00:35:30,600
+أمراض شديدة وبتكون أحياناً كثيرة يعني غير not
+
+326
+00:35:30,600 --> 00:35:35,180
+compatible even with life يعني أشياء زي ما حكينا
+
+327
+00:35:35,600 --> 00:35:43,200
+مربوط أكثر بقضية الـ Abortions، حلّات الإجهاد
+
+328
+00:35:43,200 --> 00:35:48,860
+وبتكون نتيجة إنه حدد كبير من الجينات بتكون مصابة
+
+329
+00:35:48,860 --> 00:35:53,930
+أو مختلة، سواء بالزيادة، بالنقصانبالتغيير،
+
+330
+00:35:53,930 --> 00:35:58,550
+بالتخريب، بالـ «كدا»، ففيها أشياء كثيرة في سؤال من
+
+331
+00:35:58,550 --> 00:36:04,510
+«مورا سماح»، قال يعني دكتور مش مطلوب منه نعرف
+
+332
+00:36:04,510 --> 00:36:07,410
+الأمراض الناتجة عن خلل بالجينات، بس نقتصر على
+
+333
+00:36:07,410 --> 00:36:13,990
+الأمراض الرئيسية؟ لأ، أنا يعني مش مطلوب ومطلوب
+
+334
+00:36:13,990 --> 00:36:21,760
+يعني لو واحد قرأهوحاول يفهم ونجح، ممتاز، كويس يصير
+
+335
+00:36:21,760 --> 00:36:26,660
+عنده معلومات أكثر بس أنا بتكلم أنه تفاصيل الأمور
+
+336
+00:36:26,660 --> 00:36:31,660
+يعني على إيش الجينات الموجودة على الـ Y-Chromosome
+
+337
+00:36:31,660 --> 00:36:38,340
+وشو الأليات تتخلي هذا الرجل يصير شكله رجلأنه اللي
+
+338
+00:36:38,340 --> 00:36:43,320
+بيأثر على الشعر، أنه اللي بيأثر شعر اللحن، يعني
+
+339
+00:36:43,320 --> 00:36:49,540
+ليش صوته بقى جش وحجم الحنجرة أكبر؟ ليش الـSperms
+
+340
+00:36:49,540 --> 00:36:53,180
+هم اللي بيطلعوا؟ كيف بيسيطر؟ يعني تفاصيل الأمور،
+
+341
+00:36:53,180 --> 00:37:01,560
+خلاص، اتركوني، ماشي، ما تقعدي تدقيقي وكذا وهكذا،
+
+342
+00:37:01,560 --> 00:37:10,470
+ماشي، ما تشددوشفيشدد عليكم، فاتركوا الموضوع أهم
+
+343
+00:37:10,470 --> 00:37:15,490
+شيء المبادئ الـ Barbary يمثل Inactive X-Chromosome
+
+344
+00:37:15,490 --> 00:37:20,150
+فشو ما كان فيه X-Chromosomes Inactive راح يبين
+
+345
+00:37:20,150 --> 00:37:26,750
+عددهم بشكل Barbary الأصل في مظهر الرجل يعني الـ
+
+346
+00:37:26,750 --> 00:37:31,930
+Default لو مافيش إشي تطلع أنثىيعني الإعداد
+
+347
+00:37:31,930 --> 00:37:36,390
+الإفتراضي لـ System البشر ربنا حطنا إنه تطلع
+
+348
+00:37:36,390 --> 00:37:43,030
+بالأول أنثى، ماشي؟ وجود الـ Y هو اللي يبينه على
+
+349
+00:37:43,030 --> 00:37:47,610
+شكل الرجل فأهمية الـ Y، هذه ناحية ثانية الشغل
+
+350
+00:37:47,610 --> 00:37:52,550
+الثالث إنه صح لو الـ Y موجود بس برضه مش ضروري إنه
+
+351
+00:37:52,550 --> 00:37:58,650
+يطلع ذكر ممكن يكون Y بس يكون شكلها أنثى ويكون أمور
+
+352
+00:37:58,650 --> 00:38:02,760
+مخربطة من جوهرناماشي خلّينا نحطها بهذا الشكل
+
+353
+00:38:02,760 --> 00:38:08,200
+الجداول اللي حطيتها على أو الصور اللي حطوها
+
+354
+00:38:08,200 --> 00:38:16,200
+بالنسبة الشكل climb filter تيرنار كيف بتكون هاي أه
+
+355
+00:38:16,200 --> 00:38:21,820
+هي حكيتها وذكرناها تفاصيل أكثر من هيك exact
+
+356
+00:38:21,820 --> 00:38:25,620
+details مابدوش أه في إشي تاني
+
+357
+00:38:28,670 --> 00:38:33,030
+تمام، يا دكتور، لا شيء يعني لحد اللي أنا نفسي طيب
+
+358
+00:38:33,030 --> 00:38:36,270
+الآن
+
+359
+00:38:36,270 --> 00:38:42,770
+بدنا ندخل على اللي بيسموها الوراثة المنديلية اللي
+
+360
+00:38:42,770 --> 00:38:50,630
+هم الأمراض والحالات والمشاكل اللي بيكون single
+
+361
+00:38:50,630 --> 00:39:02,780
+gene هو المسؤول عنها وهدولة يعني صحيحيعني هتلاقي
+
+362
+00:39:02,780 --> 00:39:07,620
+أعدادهم بالألاف يعني الـ Online Mendelian
+
+363
+00:39:07,620 --> 00:39:15,820
+Inheritance Website هتلاقي حوالي يعني بعشرات
+
+364
+00:39:15,820 --> 00:39:22,260
+الألاف من الأمراض وهناك مراجع ويتم تحديثها دائما
+
+365
+00:39:22,260 --> 00:39:35,950
+بقضايا يعنيبقضايا جديدة أنا بس بدي أحط صورة وديتها
+
+366
+00:39:35,950 --> 00:39:43,690
+للدكتور أحمد الأسبوع اللي فات فخليني
+
+367
+00:39:43,690 --> 00:39:48,830
+بس أضيفها هاي
+
+368
+00:39:48,830 --> 00:39:49,730
+هنا
+
+369
+00:39:53,470 --> 00:40:04,470
+خلّيني أشوف إذا بتبين هنا، لأ مش هذا، ما هو اسمه؟
+
+370
+00:40:04,470 --> 00:40:09,650
+save image على
+
+371
+00:40:09,650 --> 00:40:11,430
+الـ desktop، ماشي
+
+372
+00:40:21,420 --> 00:40:25,340
+دكتور انت ما تنسخها داخل مربع النص انسخها على
+
+373
+00:40:25,340 --> 00:40:28,400
+الشريحة نفسها يعني خارج الشريحة يعني انقر خارج
+
+374
+00:40:28,400 --> 00:40:34,660
+الشريحة اللصحة طيب خليني أشوف دقيقة، دقيقة، دقيقة،
+
+375
+00:40:34,660 --> 00:40:38,340
+دقيقة، دقيقة، دقيقة،
+
+376
+00:40:38,340 --> 00:40:41,340
+دقيقة، دقيقة، دقيقة، دقيقة، دقيقة، دقيقة، دقيقة،
+
+377
+00:40:41,340 --> 00:40:43,220
+دقيقة، دقيقة، دقيقة، دقيقة، دقيقة، دقيقة، دقيقة،
+
+378
+00:40:43,220 --> 00:40:46,380
+دقيقة، دقيقة، دقيقة، دقيقة، دقيقة، دقيقة، دقيقة،
+
+379
+00:40:46,380 --> 00:40:47,800
+دقيقة، دقيقة، دقيقة، دقيقة، دقيقة، دقيقة، دقيقة،
+
+380
+00:40:47,800 --> 00:40:50,410
+دقيقة، دقيقة، دقيقة، دقيقة، دقيقة، دهذه صورة من
+
+381
+00:40:50,410 --> 00:41:01,110
+عندي يعني عبارة عن عائلة اللي بتحكيها عبارة
+
+382
+00:41:01,110 --> 00:41:06,990
+عن أب و أم هما الأخوة من سوريا في قرابة بين الأب
+
+383
+00:41:06,990 --> 00:41:16,450
+والأم عندهم تسع أبناء و بنات التسعة خمسة منهمبطلع
+
+384
+00:41:16,450 --> 00:41:23,710
+على إيديهم ورجليهم وعلى راسهم تدرونات بهذا الشكل،
+
+385
+00:41:23,710 --> 00:41:34,350
+ماشي؟ هذه الظاهرة يعني أول شيء طبعاً لما واحد
+
+386
+00:41:34,350 --> 00:41:40,610
+يتعرف على عائلة بهذا الشكل، ماشي؟النقطة الأساسية
+
+387
+00:41:40,610 --> 00:41:47,910
+أولًا يعني لازم يحاول يروح يدور في المراجع العلمية
+
+388
+00:41:47,910 --> 00:41:53,370
+ويحاول يشوف إذا فيه إشي حد ذكر حالة قريبة حالة
+
+389
+00:41:53,370 --> 00:42:01,430
+يعني مشابهة، حالة قريبة منها فأقرب شيء لهذا المنظر
+
+390
+00:42:01,430 --> 00:42:04,670
+عبارة عن حالة تسمى «Infantile Digital
+
+391
+00:42:04,670 --> 00:42:13,740
+Fibromatosis»يعني في الأطفال على
+
+392
+00:42:13,740 --> 00:42:23,880
+الأصابع يكون هناك تليفات فيعني أنا حتى الأقرب شيء
+
+393
+00:42:23,880 --> 00:42:31,420
+بستطيع أقول إنه هذا قريب من شيء عند إنسان كانت إنه
+
+394
+00:42:31,420 --> 00:42:34,600
+هذا أقرب حالي لما حطيت الصورة تبع الـInfantile
+
+395
+00:42:34,600 --> 00:42:40,910
+Digital Fibromasosisفهي طبعًا بتكون على موليد جدد
+
+396
+00:42:40,910 --> 00:42:45,090
+هاي الظاهرة عند هاي العائلة بهذا الأطفال اللي
+
+397
+00:42:45,090 --> 00:42:48,090
+عندهم الأبناء والبنات المصابين على عمر العشرة
+
+398
+00:42:48,090 --> 00:42:53,510
+وخمستاشر سنة لإنها تبدأ تظهر وبيظل لحد عمره كبير
+
+399
+00:42:53,510 --> 00:42:57,070
+ويطلع أشياء جديدة في التلاتينات والأربعينات يعني
+
+400
+00:42:57,070 --> 00:43:02,730
+الأباء خمسينات أو ستينات الأب والأموالأبناء فيه
+
+401
+00:43:02,730 --> 00:43:07,650
+إشي تلاتين وخمس وتلاتين واشياء لحوالي عشر سنوات
+
+402
+00:43:07,650 --> 00:43:14,090
+بعضهم مصابين فلما تلاقي الواحد موضوع زي هيك بصير
+
+403
+00:43:14,090 --> 00:43:21,050
+يعني الإشكالية عندنا أول شيء دكوره إناث مصابين في
+
+404
+00:43:21,050 --> 00:43:31,300
+العائلة وعدد كبير مشترك فشكنا إنه يكونيعني خلال
+
+405
+00:43:31,300 --> 00:43:37,800
+اللي فيه قرابة بين الأبوين ممكن تكون هي autosomal
+
+406
+00:43:37,800 --> 00:43:42,980
+وليس الـ X-linked process لو X-linked كان الذكور
+
+407
+00:43:42,980 --> 00:43:47,080
+مصابين الإناف غير مصابات بس بما أنه فيه ذكور وإناف
+
+408
+00:43:47,080 --> 00:43:53,840
+معناته مشكلة بهذا الشكلالإشكالية اللي عنا وجهناها
+
+409
+00:43:53,840 --> 00:44:02,840
+لما حاولنا ندرس ويعني to report this case كانت إنه
+
+410
+00:44:02,840 --> 00:44:12,600
+ما فيش أي في العالم كله شيء سابق عن يعني قضية
+
+411
+00:44:12,600 --> 00:44:21,330
+المسبب لهذا المرض فعشان هيك يعني الـ Karyotypeأظن
+
+412
+00:44:21,330 --> 00:44:25,670
+إنه مرح، الاحتمال إنه يعني غير الأصابع وجود
+
+413
+00:44:25,670 --> 00:44:30,310
+المشكلة عليهم بهذا الشكل في الدماغ، في القلب، في
+
+414
+00:44:30,310 --> 00:44:34,790
+الأعضاء الداخلية العائلة الطبيعية، ماكانش عندهم
+
+415
+00:44:34,790 --> 00:44:39,330
+مشاكل يعني فبالنسبة إلينا يعني الاحتمال إنه هاي
+
+416
+00:44:39,330 --> 00:44:44,290
+Single Gene Disorder وبالتالي بنقول عنها
+
+417
+00:44:44,290 --> 00:44:50,600
+«Mendelian» وحاليًا أحنا غير قادرين على إنهنحدد
+
+418
+00:44:50,600 --> 00:44:54,860
+أنهو الجين فالأسلم
+
+419
+00:44:54,860 --> 00:44:59,060
+والأحسن هو أن الواحد يعمل اللي بيسموه «whole
+
+420
+00:44:59,060 --> 00:45:03,180
+genome sequencing» أني قاعد أقرأ كل الـ «DNA» تبع
+
+421
+00:45:03,180 --> 00:45:10,400
+مصاب أو مصابين وسليمان اثنين ومع الأب والأم لو عند
+
+422
+00:45:10,400 --> 00:45:18,090
+العيلة هذه بالكامل ودرستها كلهابصير بقدر أنا أحدد
+
+423
+00:45:18,090 --> 00:45:25,110
+أكثر أنه أتوقع الجين المسؤول عن هذا الأمر يعني هذه
+
+424
+00:45:25,110 --> 00:45:31,270
+تجربة خلال الفترة القريبة اللي السابقة لحالي وإنه
+
+425
+00:45:31,270 --> 00:45:36,770
+هيك العلم بتقدم إنه الواحد بيشوف مظهر معين بيشوف
+
+426
+00:45:36,770 --> 00:45:42,050
+حالة معينة بيشوف ظاهرة معينة بيحاول بعدين يفكر
+
+427
+00:45:42,050 --> 00:45:48,220
+فيها ويشوف شو أسبابهاالفكرة الثانية هي قضية إنه
+
+428
+00:45:48,220 --> 00:45:53,400
+الواحد لازم يفرق بين ما يسمى الـ «فينوتيب» والـ
+
+429
+00:45:53,400 --> 00:45:59,600
+«جينوتيب» عندما نتكلم عن تركيب الجينات والوراثة
+
+430
+00:45:59,600 --> 00:46:05,740
+لإنسان معين ماشي، ندرس هذا المستوى بيكون إحنا
+
+431
+00:46:05,740 --> 00:46:12,700
+بنتكلم عن مستوى الجيناتطبعًا من الـ … يعني كنت في
+
+432
+00:46:12,700 --> 00:46:17,960
+المحاضرة الأولى ذكرت جاروب مندل «جريجوري مندل»
+
+433
+00:46:17,960 --> 00:46:24,460
+بالـ 1840 على البازلاء وإشي كان طويل، إشي قصير،
+
+434
+00:46:24,460 --> 00:46:31,800
+إشي أخضر، إشي أصفر، إشي الوردة تبعته طرفية على
+
+435
+00:46:31,800 --> 00:46:38,660
+النهائي من فوق أو على جانب، جانبية ف… وحط قضية إنه
+
+436
+00:46:38,890 --> 00:46:45,990
+هناك مظاهر أو صفات وراثية سائدة وهناك صفات متنحية
+
+437
+00:46:45,990 --> 00:46:55,990
+فلمّا مبدأ سائد ومتنحي نتكلم هنا عن الـ Single
+
+438
+00:46:55,990 --> 00:47:02,630
+gene disorders الأشياء اللي بتكون مسؤول عنها جين
+
+439
+00:47:02,630 --> 00:47:06,950
+واحد حفظ
+
+440
+00:47:06,950 --> 00:47:13,070
+مندلإنه ما
+
+441
+00:47:13,070 --> 00:47:16,870
+قام من دراسته من كل الصفات حوالي ستة أو ثمانية
+
+442
+00:47:16,870 --> 00:47:23,690
+كانت كلها على كرموزومات مختلفة فنتج عن ذلك إنه
+
+443
+00:47:23,690 --> 00:47:33,270
+انفصال الصفاتين يعني مثلًا البازلة الصفرة الـ الـ
+
+444
+00:47:33,270 --> 00:47:42,590
+الـ المجعلقةشكل الحب تبعتها مجعلكة ولا smooth يعني
+
+445
+00:47:42,590 --> 00:47:48,950
+مش مش مجعلكة يعني فكل صفة من اللي كان بدرسها مندل
+
+446
+00:47:48,950 --> 00:47:53,890
+كانت على كرموزوم مختلف وبالتالي أعطتنا شكل معين من
+
+447
+00:47:53,890 --> 00:47:59,230
+كان استطاع أنه ينتبه لمبادع في الوراثة مهم كثير بس
+
+448
+00:47:59,230 --> 00:48:04,930
+لأنه كمان أن الحق خدمهإن السفات اللي درسها كانت
+
+449
+00:48:04,930 --> 00:48:12,210
+منفصلة عن بعض أما لو تخيلنا إنه سفتين قريبات على
+
+450
+00:48:12,210 --> 00:48:17,370
+بعض في نفس الـ Chromosome إذا مثلا إنسان عنده شيء
+
+451
+00:48:17,370 --> 00:48:23,190
+سائد لحدهما مثلا متنحي مع الآخر راح تصير عملية
+
+452
+00:48:23,190 --> 00:48:26,810
+الوراثة وعملية انتقال للسفات الوراثية راح تكون
+
+453
+00:48:26,810 --> 00:48:33,270
+خربطة أو مش بالسهولة اللي بنتكلم عنهامن الأشياء
+
+454
+00:48:33,270 --> 00:48:36,690
+اللي سويتها على طول للعائلة السورية اللي أنا
+
+455
+00:48:36,690 --> 00:48:45,070
+سويتها قضية إنه يرسم الواحد شجرة العائلة شجرة
+
+456
+00:48:45,070 --> 00:48:54,210
+العائلة مجرد حتى يعني، يعني يقترب للطبيب أو الباحث
+
+457
+00:48:54,210 --> 00:49:00,400
+من احتمالية إن يكون هناك مرض وراثيوممكن الواحد
+
+458
+00:49:00,400 --> 00:49:05,640
+يشترك مع العالم كله أنه يعني بعدين يلاقي وين الجين
+
+459
+00:49:05,640 --> 00:49:09,720
+المسؤول عن هذا الأمر فيه هناك عدد كبير من الجينات
+
+460
+00:49:09,720 --> 00:49:14,100
+نحن لا نعلم شو وظيفتها بالضبط، ليش ربنا حطها فينا،
+
+461
+00:49:14,100 --> 00:49:19,360
+وكيف بتشتغل، كيو بتعمل، لسه فيه مجاهيل كثيرة،
+
+462
+00:49:19,360 --> 00:49:25,240
+وبدالواحد دايما يشترك أنه يطور الموضوع، فأهم شيء
+
+463
+00:49:25,240 --> 00:49:32,500
+أنهبالأول، بأول ما يشوف الحالة يرسم شجرة العائلة
+
+464
+00:49:32,500 --> 00:49:38,220
+يرسم اللي بيسموه الـ Pedigree اللي هو الشجرة
+
+465
+00:49:38,220 --> 00:49:46,320
+العائلة للإصابة وللعائل المصابة وبالتالي يعني يجمع
+
+466
+00:49:46,320 --> 00:49:57,540
+تفاصيل في شكل يعني بسيط ويعنيجدول صغير حجمه صغير
+
+467
+00:49:57,540 --> 00:50:05,120
+بس يحط فيه معلومات كبيرة جداً جداً فالآن الـ
+
+468
+00:50:05,120 --> 00:50:10,440
+Pedigree بتبدأ إن الواحد لازم يميز الرموز الموجودة
+
+469
+00:50:10,440 --> 00:50:19,060
+لما نحط مربع فالمقصود فيه Male هو ذكر المستديرة
+
+470
+00:50:19,060 --> 00:50:27,340
+Femaleإذا حطه معين فإنه يكون sex unspecified يعني
+
+471
+00:50:27,340 --> 00:50:34,720
+مثلا إجهاد مبكر وكان مش مبين إن هذا ذكر ولا أنثى
+
+472
+00:50:34,720 --> 00:50:42,630
+والله جدة إمي كان عندها سبع أبناء وبناتطب قداش
+
+473
+00:50:42,630 --> 00:50:47,030
+الذكور؟ قداش الإنث؟ حد عنده تفصيل؟ لأ والله ما حد
+
+474
+00:50:47,030 --> 00:50:51,370
+عنده تفصيل إذا ماعنديش تفصيل بحطه بشكل يعني ده بقى
+
+475
+00:50:51,370 --> 00:50:57,090
+كنت لا أعلم إذا كان بشكل أكيد ذكر ولا أنثى بحط
+
+476
+00:50:57,090 --> 00:51:06,330
+الواحد هذا الشكل في جيل معين ماشيإذا بحط أرقام
+
+477
+00:51:06,330 --> 00:51:13,650
+ماشي بهذا
+
+478
+00:51:13,650 --> 00:51:18,830
+الشكل هنا number of children of six indicated يعني
+
+479
+00:51:18,830 --> 00:51:23,330
+زي ما حكينا هنا مثلا قبل شوية واحد يقول جدة أخال
+
+480
+00:51:23,330 --> 00:51:29,690
+أبوي كان عندها خمسة تلاتة ذكور واثنين اناث بهذا
+
+481
+00:51:29,690 --> 00:51:34,170
+الشكلفإذا حطوا الرقم جوا على العكس هنا واحد،
+
+482
+00:51:34,170 --> 00:51:39,390
+اثنين، ثلاثة فهنا الشخص الأول، الشخص الثاني، الشخص
+
+483
+00:51:39,390 --> 00:51:43,970
+الثالث الأول ولد، ثاني بنت وبعدين بنت، بهذا
+
+484
+00:51:43,970 --> 00:51:47,990
+الترتيب هنا number of children of six indicated
+
+485
+00:51:47,990 --> 00:51:54,410
+يعني المجموع الأب والأم هؤلاء مثلًا جابوا خمسة
+
+486
+00:51:54,410 --> 00:52:00,860
+ثلاث ولاد وبنتين، هكذا لما نحط اللون الأزرقماشي
+
+487
+00:52:00,860 --> 00:52:05,900
+فبمعناته affected مصاب segments filled for
+
+488
+00:52:05,900 --> 00:52:12,220
+different components of the phenotype يعني أنا كنت
+
+489
+00:52:12,220 --> 00:52:19,460
+بعرف مثلا أنثى حامل بهذا الشكل إنسان أنا درسته
+
+490
+00:52:19,460 --> 00:52:25,060
+يعني مثلا عنده الـ gene اللي فلاني أنا عارف مثلا
+
+491
+00:52:25,060 --> 00:52:30,520
+واحد عنده blood group إيههو الممكن يكون AA ممكن
+
+492
+00:52:30,520 --> 00:52:37,080
+يكون AO فإذا أنا عارف أنه مثلا AO بحطه أنه نص A
+
+493
+00:52:37,080 --> 00:52:42,960
+ونص O مثلا يعني ده كنت بعرف Non-penetrant carrier
+
+494
+00:52:42,960 --> 00:52:50,880
+may manifest disease يعني هو أنا اللي أحياناً نحكي
+
+495
+00:52:50,880 --> 00:52:54,440
+عن بعض الـ يعني بنحب أنه نظن أنه
+
+496
+00:52:57,770 --> 00:53:02,370
+الجينات والماد الوراثية والصفات الوراثية بنفكر
+
+497
+00:53:02,370 --> 00:53:05,090
+الأليل الـ dominant و الـ recessive الـ dominant
+
+498
+00:53:05,090 --> 00:53:10,070
+يعني بظهر و الـ recessive يعني متنحي و بتخبأ،
+
+499
+00:53:10,070 --> 00:53:15,530
+ببينش بس الدنيا مش أبيض و أسود مش فقط يا إما مصاب
+
+500
+00:53:15,530 --> 00:53:22,810
+يا إما غير مصاب أو سليم أحياناًفي درجة ظهور الحالة
+
+501
+00:53:22,810 --> 00:53:29,350
+الوراثية تتأثر بأشياء ثانية، يعني مثلًا الصلاق جزء
+
+502
+00:53:29,350 --> 00:53:36,430
+منه فيه جين مسؤول عن الصلاق وبيأثر إذا الأنثى
+
+503
+00:53:36,430 --> 00:53:42,390
+عندها أثنين منه أه بتبين يعني فيه بيبين صلاق أكثر
+
+504
+00:53:42,390 --> 00:53:49,360
+على رأسها بشكل واضحبينما في الأنثى لازم اثنين يكون
+
+505
+00:53:49,360 --> 00:53:54,340
+الجينات المسببة للصلاة بينما عند الرجال واحد بس
+
+506
+00:53:54,340 --> 00:53:58,380
+بيكفي، بيكون dominant وبتلاقي، بيبين صلاة أكثر من
+
+507
+00:53:58,380 --> 00:54:03,080
+كثير هي قضية اللي بيسموها الـ Penetration of the
+
+508
+00:54:03,080 --> 00:54:08,880
+Character يعني درجة قدرتها على الظهورObligate
+
+509
+00:54:08,880 --> 00:54:12,460
+carrier will not manifest disease يعني ليه الحامل
+
+510
+00:54:12,460 --> 00:54:18,660
+للمرضأحيانًا، يعني إحنا بنكون متأكدين إنه ظهر عند
+
+511
+00:54:18,660 --> 00:54:26,260
+إنسان مرض وكان نتيجة إنه موجود عند أبوه أو أمه، بس
+
+512
+00:54:26,260 --> 00:54:33,000
+كان الواحد منهم مش مصعب بس يعني إذا ماكنتش طفرة في
+
+513
+00:54:33,000 --> 00:54:37,680
+نفس الشخص فلازم تكون في والده أو والدته، وبالتالي
+
+514
+00:54:37,680 --> 00:54:45,610
+نرسمها بهذا الشكلإذا الشخص اللي بنتكلم عنه «موت»
+
+515
+00:54:45,610 --> 00:54:51,370
+يعني متوفى بنحط عليه خط بهذا الشكل Spontaneous
+
+516
+00:54:51,370 --> 00:55:00,270
+abortion يعني قضية إجهاد ذاتي بكون سواء مصاب أو
+
+517
+00:55:00,270 --> 00:55:07,310
+غير مصاب طبعاً هو أنا مبكر فبالتالي يعني في الأشهر
+
+518
+00:55:07,310 --> 00:55:12,530
+الأولى من الحمليمكن ما يبين ذكر ولا أنثى، ماشي،
+
+519
+00:55:12,530 --> 00:55:17,070
+بنرسمها بهذا الشكل دكتور، في سؤال من كريم، بيسأل
+
+520
+00:55:17,070 --> 00:55:23,850
+شو في أمثلة على الـobligate career؟ لأ، أنت لما
+
+521
+00:55:23,850 --> 00:55:34,190
+تتكلم عن حالة مثلا، نفترض ناخد مرض Huntington's
+
+522
+00:55:34,190 --> 00:55:41,800
+Chorea، مثلاإبارة عن مرض «Autosomal Dominant» فهو
+
+523
+00:55:41,800 --> 00:55:45,920
+سائد بتلاقي
+
+524
+00:55:45,920 --> 00:55:49,800
+الانسان
+
+525
+00:55:49,800 --> 00:55:56,720
+أنت شفته مرض يعني يعني
+
+526
+00:55:56,720 --> 00:56:01,340
+لما بدك تاخذه لما تشوف إنسان مصاب فيه أحيانًا ممكن
+
+527
+00:56:01,340 --> 00:56:06,850
+يكون أنههي طفرة اللي سببت المرض نشأت في هذا الشخص
+
+528
+00:56:06,850 --> 00:56:12,330
+وهو هينقلها لأولاده وبناته، ماشي؟ بس بيظل في
+
+529
+00:56:12,330 --> 00:56:18,350
+أحيانًا احتمالية إنه كان موجود في أبوه أو أمه
+
+530
+00:56:18,350 --> 00:56:23,410
+وكانت Carrier ولازم يكون Carrier يعني إذا بتاخد
+
+531
+00:56:23,410 --> 00:56:27,890
+مثلًا في الـ X-Chromosomes مثلًا الـG6PD
+
+532
+00:56:27,890 --> 00:56:34,660
+Deficiency جزء منه X-linked recessiveفالأم الأنثى
+
+533
+00:56:34,660 --> 00:56:40,100
+هي الحامل لازم بشكل إجباري تكون هي الحامل حتى
+
+534
+00:56:40,100 --> 00:56:45,860
+تعطيه يعني إذا واحد في مرض هو أخواله اللي هو الـ X
+
+535
+00:56:45,860 --> 00:56:53,320
+-linked chromosomes بتلاقي معناته الأم الأنثى كانت
+
+536
+00:56:53,320 --> 00:56:57,340
+هي ما بنقول عنها مصابة بس لازم تكون حامل لأنه غير
+
+537
+00:56:57,340 --> 00:57:02,420
+هيك ما كان انتقل للطفل هذافاهم عليك كيف؟ فيعني هي
+
+538
+00:57:02,420 --> 00:57:09,440
+الفكرة أن أنا بس الآن بدي أخذكم خلال الرموز هذه
+
+539
+00:57:09,440 --> 00:57:13,460
+حتى لما تشوفوها بعدين تفهموا شو معناها يعني أنا
+
+540
+00:57:13,460 --> 00:57:17,680
+هذا الآن بحاول أزويه، ماشي؟ تفاصيل الأمور، راح
+
+541
+00:57:17,680 --> 00:57:21,920
+ناخد أمثل كثيرة ونتكلم عنها، يصير الواحد يكون
+
+542
+00:57:21,920 --> 00:57:27,200
+مرتاحة ويحكي عن حاجة معينة، ماشي؟
+
+543
+00:57:29,990 --> 00:57:35,770
+الخط الثاني من فوق Marriage أو Union يعني زواج لما
+
+544
+00:57:35,770 --> 00:57:40,810
+نحط ذكر وأنثى بهذا الشكل إذا حطيت خطين بالنص هنا
+
+545
+00:57:40,810 --> 00:57:45,790
+يعني مطلقين إذا حطيت Double Bond يعني
+
+546
+00:57:45,790 --> 00:57:53,110
+Consanguinity يعني زواج أقارب ماشي لما تحط إنه
+
+547
+00:57:53,110 --> 00:57:57,090
+مثلًا من العائلة هذه الذكر والأنثى هذولة مثلًا
+
+548
+00:57:57,650 --> 00:58:03,410
+تنزلك خطين بهذا الشكل وبينهم بعدين خط بالنص
+
+549
+00:58:03,410 --> 00:58:08,010
+«monozygotic twins» «monozygotic» يعني توائم
+
+550
+00:58:08,010 --> 00:58:16,850
+متطابقة فبتكون من نفس الجنس وبيكون متطابقين، نحطها
+
+551
+00:58:16,850 --> 00:58:22,900
+هكذا إذا «dizygotic twins» ممكن يكون واحدذاكر واحد
+
+552
+00:58:22,900 --> 00:58:27,520
+أنثى مثلًا توقم واحد ذكر واحد أنثى أو إثنينهم إناث
+
+553
+00:58:27,520 --> 00:58:32,900
+أو إثنينهم ذكور بيصير بس بنحطها بهذا الشكل يعني مش
+
+554
+00:58:32,900 --> 00:58:38,300
+زي الصورة هذه هنا العيلة هذه مثلًا الأب والأم
+
+555
+00:58:38,300 --> 00:58:42,860
+جابوا الطفل الأول ذكر بعدين الطفل الثاني كانت أنثى
+
+556
+00:58:42,860 --> 00:58:47,560
+يعني بهذا الشكل جابوه محمال مختلفة فبنحط من نفس
+
+557
+00:58:47,560 --> 00:58:56,630
+المصدر بيكون في نفس الحملماشي إذا كان فيه عدم ..
+
+558
+00:58:56,630 --> 00:59:04,150
+يعني عدم تأكد من نوعية الـ Zygote يعني هل هو توائم
+
+559
+00:59:04,150 --> 00:59:08,330
+متطابقة أو لغير متطابقة الواحد بحق علامة استفهام
+
+560
+00:59:08,330 --> 00:59:17,410
+إذا ما عنده يعني ثقة 100% Stillbirth اللي هو وفاة
+
+561
+00:59:17,410 --> 00:59:27,200
+في آخر الحملبحيث أنه يكون مبين ذكره لأنثى وبينحط
+
+562
+00:59:27,200 --> 00:59:34,200
+عليه علامة خط ماشي بهذا الشكل still birth وبكون
+
+563
+00:59:34,200 --> 00:59:40,500
+يعني وفاة في أواخر الحمل بكون مرحلة متقدمة adopted
+
+564
+00:59:40,500 --> 00:59:46,400
+into the family بهذا الشكلالحالة اللي هو التبني
+
+565
+00:59:46,400 --> 00:59:52,260
+يعني شخص مادة الوراثية مش من هذه العائلة بس اتبنته
+
+566
+00:59:52,260 --> 00:59:58,080
+هذه العائلة adopted out of the family يعني حاطين
+
+567
+00:59:58,080 --> 01:00:06,620
+هنا الفروقات شكل الخط اللي يعني حاطينه للعلاقة
+
+568
+01:00:06,620 --> 01:00:12,720
+العائلة هذه بهذا الإنسان هنا ذكر هنا أنتهنا
+
+569
+01:00:12,720 --> 01:00:19,400
+الأمثلة أخدت عائلة ثانية وهنا العائلة أخدت بكر من
+
+570
+01:00:19,400 --> 01:00:28,060
+عائلة أخرى pregnancy with information on details
+
+571
+01:00:28,060 --> 01:00:33,700
+if available يعني حالياً في حمل بس احنا مش عارفين
+
+572
+01:00:33,700 --> 01:00:42,730
+يعني لسه ماولدت هي last menstrual periodتاريخ أو
+
+573
+01:00:42,730 --> 01:00:47,730
+أنه حامل على أربع وعشرين أسبوع من أربعين أسبوع
+
+574
+01:00:47,730 --> 01:00:53,070
+لحمل تسعة شهر أو أنه آخر يوم في الدورة في هذا
+
+575
+01:00:53,070 --> 01:00:57,550
+الحمل بتاريخ أتنين، أشرين، أتناش، ألفين واربعتاش
+
+576
+01:00:57,550 --> 01:01:02,570
+مثلاً، فإذا كان يعني عندنا details عن ال pregnancy
+
+577
+01:01:02,570 --> 01:01:07,510
+بنحطها بهذا الشكل الآن هذه بيسموها الـ Pedigree
+
+578
+01:01:07,510 --> 01:01:14,300
+اللي هو اللي بيكون بهذا الشكللما نحط الـ Times
+
+579
+01:01:14,300 --> 01:01:19,100
+Roman في هذا الشكل اللي هو الأجيال، هذا الجيل
+
+580
+01:01:19,100 --> 01:01:23,040
+الأول، هذا الجيل الثاني، هذا الجيل الثالث، الرابع،
+
+581
+01:01:23,040 --> 01:01:29,500
+قدر ما بدي بحط الشخص الأول هنا، الجيل الأول مثلا
+
+582
+01:01:29,500 --> 01:01:34,950
+الذكر، و بعدين زوجته، و بعدين هنا الجيل الثانيذاكر
+
+583
+01:01:34,950 --> 01:01:39,390
+ولد الأول وبعدين البنت الثانية والبنت الثالثة
+
+584
+01:01:39,390 --> 01:01:44,610
+البنت الثانية هي المصابة أحياناً الـ broadband
+
+585
+01:01:44,610 --> 01:01:50,250
+اللي هو الشخص اللي خلانا نكتشف المشكلة في هذه
+
+586
+01:01:50,250 --> 01:01:54,010
+العائلة أو خلانا ندرس هذا الموضوع في هذه العائلة
+
+587
+01:01:54,010 --> 01:02:00,030
+يعني ممكن مثلا أنا أجيإنسان مثلًا إندونازف يعمل له
+
+588
+01:02:00,030 --> 01:02:03,670
+الـ Bt و الـ Btt و يشوف أن هي طالع عنده هموفيليا
+
+589
+01:02:04,110 --> 01:02:09,050
+الـ Hemophilia Ex-Linked Recessive اكتشفتها هنا
+
+590
+01:02:09,050 --> 01:02:13,230
+بعدين باجي بدقيق الأهل آه والله أخواله في عندهم
+
+591
+01:02:13,230 --> 01:02:17,870
+كان فيهم مشكلة معينة بصير بعدين يطلع و بعدين أخوال
+
+592
+01:02:17,870 --> 01:02:22,570
+أمه في بلد ثاني مابيعرفوش عنها يمكن يكون شخص مصاب
+
+593
+01:02:22,570 --> 01:02:28,450
+فكل ما يعني نكتشف أكثر بنضيف أفراد و حالات و شو
+
+594
+01:02:28,450 --> 01:02:34,770
+وضعهمولما انا اكون الشخص اللي بدأت في الاهتمام في
+
+595
+01:02:34,770 --> 01:02:38,710
+هذه القصة بنسميه الـ Proband اللي هو الشخص اللي
+
+596
+01:02:38,710 --> 01:02:45,770
+بدأنا فيه القصة Arrow indicates consulted seeking
+
+597
+01:02:45,770 --> 01:02:53,520
+counselingهنا راح نحكي مثلًا مثال شغلات بتخوف وبظل
+
+598
+01:02:53,520 --> 01:02:58,880
+الواحد لما تصير يصير قلقان بدي يفحص الجينات عشان
+
+599
+01:02:58,880 --> 01:03:05,580
+يشوف هل أنا مصاب، هل في احتمالية إصابتي، كم نسبة
+
+600
+01:03:05,580 --> 01:03:12,600
+لغيري، كذا كذافإذا شخص لسه بده يعرف هل هو هيصاب أو
+
+601
+01:03:12,600 --> 01:03:18,060
+لا يصاب أو كذا بنحطه سهم بهذا الشكل إذا سهم على
+
+602
+01:03:18,060 --> 01:03:26,620
+يعني فراغ مصمت باللون الأزرق كامل بهذا الشكل فهو
+
+603
+01:03:26,620 --> 01:03:31,080
+مصاب وهنا الـ Proband اللي هو يعني بدأت الدراسة
+
+604
+01:03:31,080 --> 01:03:38,430
+عليهإذا هنا فهو شخص يأتي يستفتي عشان يسأل هل أنا
+
+605
+01:03:38,430 --> 01:03:43,350
+سأصاب ولا لأ، بدي أعيش و أضغط، فبحطه على شكل بهذا
+
+606
+01:03:43,350 --> 01:03:49,110
+الشكل، إذا شخصين ما كان عندهم ضرية، no offspring،
+
+607
+01:03:49,110 --> 01:03:55,780
+بنحطها بهذا الشكل، وإذا واحد اتزوج زوجتين،فبتقول
+
+608
+01:03:55,780 --> 01:03:59,980
+الزوج الأولى وهذه الزوج الثانية نحطهم بهذا الشكل
+
+609
+01:03:59,980 --> 01:04:08,820
+إذا صار إجهاض مش spontaneous يعني إجهاض زي في دول
+
+610
+01:04:08,820 --> 01:04:13,870
+ثانية أو في أوضاع ثانيةبكون المرأة حقًا تجد حالها
+
+611
+01:04:13,870 --> 01:04:18,510
+فبتصير يعني إنه Termination of Pregnancy بتبروها
+
+612
+01:04:18,510 --> 01:04:24,510
+في بعض المجتمعات حق للأنثى بشو اسمه؟ بيكون إنه
+
+613
+01:04:24,510 --> 01:04:30,410
+بتحطها بهذا الشكل، ماشي فهي مجمل يعني أنا بعتبر
+
+614
+01:04:30,410 --> 01:04:40,450
+مهم كثير لحضراتكم إنه الواحد يعرف وينتبهويميز شو
+
+615
+01:04:40,450 --> 01:04:46,250
+معنى كل رمز من الرموز هذه في الـ Pedigree اللي
+
+616
+01:04:46,250 --> 01:04:50,030
+لازم نرسمه وراح نلاحظ بعدين لما تتطلع على الـ
+
+617
+01:04:50,030 --> 01:04:55,830
+Pedigree وتشوف يعني كيف شكله وشو هو تقدر تحدد أنه
+
+618
+01:04:55,830 --> 01:05:02,620
+المتوقع طبيعة الورافة للمرض اللي أنت بتتكلم عنههذه
+
+619
+01:05:02,620 --> 01:05:12,180
+هنا يعني مثلًا عائلة طرينا ندرسها من خمس أجيال،
+
+620
+01:05:12,180 --> 01:05:19,720
+ماشي؟ الشخص المصاب اللي هي أنثى هي عبارة عن اللي
+
+621
+01:05:19,720 --> 01:05:28,080
+عليها السهم بهذا الشكل، ماشي؟ هنا هي مصابة وهي
+
+622
+01:05:28,080 --> 01:05:34,570
+اللي يعني بدأت اهتمامنا بهذه العائلةطبعًا متزوجي
+
+623
+01:05:34,570 --> 01:05:48,030
+رجل طبيعي، أبيض، وخلفت منه تلت أفراد، بنت وولدين،
+
+624
+01:05:48,030 --> 01:05:54,190
+عندهم المشكلة هذه، يعني زي أمهم طالعين هيك، حاطين
+
+625
+01:05:54,190 --> 01:06:01,170
+هنا ال .. يعني ال .. ال .. ال .. لما نتكلم
+
+626
+01:06:03,530 --> 01:06:09,450
+عن الشخص المصاب اللي هو هنا، ماشي؟ لما نتكلم عن
+
+627
+01:06:09,450 --> 01:06:17,590
+الشخص المصاب هنا اللي عليها السهم، ماشي؟ لما نحطه
+
+628
+01:06:17,590 --> 01:06:21,710
+جنبها واحد، فهي اللي يسموها الـ First-degree
+
+629
+01:06:21,710 --> 01:06:26,650
+relative يعني قرابة من الدرجة الأولى، مين أقربها
+
+630
+01:06:26,650 --> 01:06:32,250
+الإنسان الدرجة الأولى؟ أول شيء، أبوه وأمه، ماشي؟
+
+631
+01:06:32,660 --> 01:06:37,140
+فهي بالـ Third Generation إذا بتنتبهوا هنا هذا
+
+632
+01:06:37,140 --> 01:06:41,640
+والدها وهذه أمها فهذا بنعتبرها First Degree
+
+633
+01:06:41,640 --> 01:06:48,160
+أخوانها وخواتها برضه First Degree ولادها وبناتها
+
+634
+01:06:48,160 --> 01:06:54,400
+First Degree فدولة يعني هنا لما نيجي نتكلم يعني
+
+635
+01:06:54,400 --> 01:06:58,820
+مثلا على الـ Risk للـ Atherosclerosis المفروض كلمة
+
+636
+01:06:58,820 --> 01:07:04,120
+دايما بحكيها للطلاب إنهاإنه والله واحد يقول لي إبن
+
+637
+01:07:04,120 --> 01:07:08,120
+عمي صابه مشكلة قلب على عمره صغير، هاي مش risk
+
+638
+01:07:08,120 --> 01:07:11,060
+factor له، مش first degree، مش اللي هي اللي
+
+639
+01:07:11,060 --> 01:07:13,280
+بيسموها الـ major risk factors لأولاد الـ
+
+640
+01:07:13,280 --> 01:07:20,940
+sclerosis، هاي تعتبر minor risk factor أو مش لأنها
+
+641
+01:07:20,940 --> 01:07:24,260
+first degree relative فاللي حاطين عليهم واحد
+
+642
+01:07:24,260 --> 01:07:29,760
+حوالين البنت هذه، ماشي، هاي first degree relative
+
+643
+01:07:30,400 --> 01:07:37,700
+انتبهوا إن زوجها وجوز بنتها لا تعتبر قرابي بينهم
+
+644
+01:07:37,700 --> 01:07:43,300
+وبينها، ماشي؟ فدولة مافيش قرابي بينها وبينها، لما
+
+645
+01:07:43,300 --> 01:07:50,040
+نيجي ناخد جيل أبكر من ذلك، مثلا الجدود، هدولة
+
+646
+01:07:50,040 --> 01:07:56,940
+second degree relative، ولاد العم، يعني الـ، آسف،
+
+647
+01:07:56,940 --> 01:08:05,200
+هنا، هي هنا المصابة،ماشي هذا أبوها إذا هاي عمتها
+
+648
+01:08:05,200 --> 01:08:14,720
+هنا هاي أمها يبقى هذا خالها الخال والعم مثلا
+
+649
+01:08:14,720 --> 01:08:21,200
+second degree relative ماشي الحفيد second degree
+
+650
+01:08:21,200 --> 01:08:27,200
+relative ماشي ال .. بالنسبة لل third degree
+
+651
+01:08:27,200 --> 01:08:33,830
+relative يعني كل ما ببعددرجة بثير باعتبره درجة
+
+652
+01:08:33,830 --> 01:08:43,250
+القرابة وقوة التطابق في المادة الوراثية يعني ماشي
+
+653
+01:08:43,250 --> 01:08:49,070
+فمن
+
+654
+01:08:49,070 --> 01:08:56,490
+الأشياء اللي يعني هيك بشكل واضح منديلية
+
+655
+01:08:57,010 --> 01:09:03,470
+الفصيلة الدم الـ ABO blood group الماشي الـ ABO
+
+656
+01:09:03,470 --> 01:09:10,430
+blood group لما نتكلم على مستوى الـ Genotype يعني
+
+657
+01:09:10,430 --> 01:09:15,950
+على مستوى الأليلز الموجودة في الـ DNA اللي موجودة
+
+658
+01:09:15,950 --> 01:09:22,710
+في هذا الـ locus بتلاقي الاحتمالات في ثلاث أليلز،
+
+659
+01:09:22,710 --> 01:09:29,530
+الـ O والـ A والـ Bوالإنسان يا إما OO أو AB أو AA
+
+660
+01:09:29,530 --> 01:09:36,770
+أو AB أو BB أو BO أو AO يعني بهذه الإحتمالات الـ
+
+661
+01:09:36,770 --> 01:09:41,970
+Phenotype بين البشر اللي أنا بلاقيهم إذا OO راح
+
+662
+01:09:41,970 --> 01:09:48,630
+يطلع O إذا AB فيه Co-dominant يعني هذه مبدأ إن
+
+663
+01:09:48,630 --> 01:09:55,220
+أثنين أقوياء وظاهرين أثنينهم dominant على الـ Oبس
+
+664
+01:09:55,220 --> 01:10:00,640
+إذا اثنين كان «A» و «B» إثنين بيبينوا «A» «B» فهي
+
+665
+01:10:00,640 --> 01:10:07,080
+بتكون طبعاً إذا «AA» أو «AO» بيبين Phenotype «A»
+
+666
+01:10:07,080 --> 01:10:12,200
+إذا «BB» أو «BO» بيبين Phenotype «B» هذولة الـ
+
+667
+01:10:12,200 --> 01:10:18,580
+Phenotype on RBCs يعني هذولة الـ Antigen هذولة
+
+668
+01:10:18,580 --> 01:10:24,040
+المظهر تبعت الإنسان هذا نتيجة هذه الجينات بهذا
+
+669
+01:10:24,040 --> 01:10:30,960
+الشكللو جيت أنا أشوف الـ Anti-A وAnti-B اللي بحطه
+
+670
+01:10:30,960 --> 01:10:37,700
+لما قاعد أفحص الـ الـ blood group، ماشي بحط نقطة
+
+671
+01:10:37,700 --> 01:10:42,420
+الـ Anti-A وAnti-B وبسوي وبعدين بحر هن هيكي وعشان
+
+672
+01:10:42,420 --> 01:10:46,800
+أشوف ده فيه agglutination وبكون معناته positive،
+
+673
+01:10:46,800 --> 01:10:51,220
+فيه reaction إذا مافيه reaction للإثنين، بكون O
+
+674
+01:10:51,220 --> 01:10:57,410
+إذا كانت reaction للـA بس، فهو Aبس جينياً ياما AA
+
+675
+01:10:57,410 --> 01:11:03,250
+أو AO إذا بي بس، يعني بي، الـ Blood Group، يا BB
+
+676
+01:11:03,250 --> 01:11:10,730
+يا BO إذا اشترك بالإثنين، بتكون AB، لهذا الشكل،
+
+677
+01:11:10,730 --> 01:11:20,830
+فدولا بالـ Test، ماشي، بعد عمر السنةيعني الـ
+
+678
+01:11:20,830 --> 01:11:25,270
+Antigens للـ ABO Blood Group بتكون مش بس على الـ
+
+679
+01:11:25,270 --> 01:11:27,450
+Red Blood Cells اللي أهم من الـ Red Blood Cells
+
+680
+01:11:27,450 --> 01:11:32,090
+موجودة على الـ Endothelium موجودة على غشاء الطبقة
+
+681
+01:11:32,090 --> 01:11:37,030
+المبطنة للأوعي الدموية فهي أهم من الـ Red Blood
+
+682
+01:11:37,030 --> 01:11:41,590
+Cells بس طبعاً احنا اكتشفناهم على تأثيرهم على الـ
+
+683
+01:11:41,590 --> 01:11:49,280
+Red Blood Cells فبعد عمر السنةبظهر في الإنسان بالـ
+
+684
+01:11:49,280 --> 01:11:53,780
+Antibodies اللي موجودة في الـ Serum فاللي عنده AB
+
+685
+01:11:53,780 --> 01:11:58,480
+Blood Group ماعندوش أي نوع Antibodies ضد الـ A ولا
+
+686
+01:11:58,480 --> 01:12:04,200
+ضد الـ B إذا عنده B Blood Group راح يتكون في جسمه
+
+687
+01:12:04,200 --> 01:12:09,480
+Anti-A وإذا عنده Blood Group A بتكون الـ Anti-B
+
+688
+01:12:09,480 --> 01:12:15,850
+وإذا عنده Oبيتكون A وB، Anti-A وAnti-B طبعاً هذولة
+
+689
+01:12:15,850 --> 01:12:20,310
+مبادئ أهميتهم أولاً في الـBlood Transfusion أمتى
+
+690
+01:12:20,310 --> 01:12:26,350
+بقدر أعطي دم الإنسان لإنسان، لازم مافي مجال أعطيه
+
+691
+01:12:26,350 --> 01:12:34,130
+كرات دم حمر يكون في جسمه أجسام مضادة ضدهم وبالتالي
+
+692
+01:12:34,130 --> 01:12:41,890
+تعمل reaction وتعمل مشكلة كبيرة كثيرأنا مضطر أن
+
+693
+01:12:41,890 --> 01:12:50,750
+أقف هنا و بنكمل الأسبوع الجاي، في أسئلة؟
+
+694
+01:12:50,750 --> 01:12:57,850
+في أسئلة؟ إذا في أسئلة عندكم يا دكاترة، فيا ..
+
+695
+01:12:57,850 --> 01:13:01,670
+يعني يا بت .. بتسألوها أو بتبعتوها رسالة، رسالة
+
+696
+01:13:01,670 --> 01:13:06,170
+يعني نعم، نعم، ماشي
+
+697
+01:13:07,180 --> 01:13:12,860
+الله يوفقكم و باعتدر اليوم يعني غير شكل كان عندي
+
+698
+01:13:12,860 --> 01:13:17,820
+شغل إيماني عارف هيك الحمد لله على كل حالة الله
+
+699
+01:13:17,820 --> 01:13:19,960
+يعطيك الخير يا دكتور الله يعطيك الخير يا دكتور
+
+700
+01:13:19,960 --> 01:13:20,640
+الله يعطيك الخير يا دكتور الله يعطيك الخير يا
+
+701
+01:13:20,640 --> 01:13:20,880
+دكتور الله يعطيك الخير يا دكتور الله يعطيك الخير
+
+702
+01:13:20,880 --> 01:13:20,900
+يا دكتور الله يعطيك الخير يا دكتور الله يعطيك
+
+703
+01:13:20,900 --> 01:13:21,160
+الخير يا دكتور الله يعطيك الخير يا دكتور الله
+
+704
+01:13:21,160 --> 01:13:22,880
+يعطيك الخير يا دكتور الله يعطيك الخير يا دكتور
+
+705
+01:13:22,880 --> 01:13:24,160
+الله يعطيك الخير يا دكتور الله يعطيك الخير يا
+
+706
+01:13:24,160 --> 01:13:25,560
+دكتور الله يعطيك الخير يا دكتور الله يعطيك الخير
+
+707
+01:13:25,560 --> 01:13:25,800
+يا دكت
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/KblmxBN0mak_raw.json b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/KblmxBN0mak_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..5e9f4df7dd6673fc4cf4c8d2de28f03e8c3db034
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/KblmxBN0mak_raw.json
@@ -0,0 +1 @@
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Translocation", "probability": 0.7801106770833334}, {"start": 165.34, "end": 168.42, "word": " من", "probability": 0.8505859375}, {"start": 168.42, "end": 169.12, "word": " الأمثلة", "probability": 0.97705078125}, {"start": 169.12, "end": 169.46, "word": " على", "probability": 0.9375}, {"start": 169.46, "end": 174.54, "word": " جزء", "probability": 0.8400065104166666}, {"start": 174.54, "end": 174.76, "word": " من", "probability": 0.9931640625}, {"start": 174.76, "end": 175.14, "word": " الـ", "probability": 0.970947265625}, {"start": 175.14, "end": 175.56, "word": " DNA", "probability": 0.65625}, {"start": 175.56, "end": 177.8, "word": " اللي", "probability": 0.69091796875}, {"start": 177.8, "end": 178.08, "word": " هي", "probability": 0.87548828125}, {"start": 178.08, "end": 178.86, "word": " موضوع", "probability": 0.965576171875}, {"start": 178.86, "end": 179.96, "word": " الـ", "probability": 0.876708984375}, {"start": 179.96, "end": 180.64, "word": " Dijord", "probability": 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"start": 228.02, "end": 241.52, "text": "الـ Dijord Syndrome الـ Dijord Syndrome هو عبارة عن", "tokens": [6027, 39184, 413, 1718, 765, 44545, 2423, 39184, 413, 1718, 765, 44545, 31439, 6225, 3555, 9640, 3660, 18871], "avg_logprob": -0.38754111528396606, "compression_ratio": 1.2, "no_speech_prob": 0.0, "words": [{"start": 228.01999999999998, "end": 229.14, "word": "الـ", "probability": 0.63623046875}, {"start": 229.14, "end": 229.74, "word": " Dijord", "probability": 0.360595703125}, {"start": 229.74, "end": 230.3, "word": " Syndrome", "probability": 0.533203125}, {"start": 230.3, "end": 235.7, "word": " الـ", "probability": 0.6820068359375}, {"start": 235.7, "end": 239.9, "word": " Dijord", "probability": 0.777099609375}, {"start": 239.9, "end": 240.36, "word": " Syndrome", "probability": 0.796875}, {"start": 240.36, "end": 240.74, "word": " هو", "probability": 0.8037109375}, {"start": 240.74, "end": 241.24, "word": " عبارة", "probability": 0.9971923828125}, {"start": 241.24, "end": 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"end": 260.96, "word": " بتكون", "probability": 0.909912109375}, {"start": 260.96, "end": 261.92, "word": " فيها", "probability": 0.986328125}, {"start": 261.92, "end": 262.78, "word": " اختلال", "probability": 0.9658203125}, {"start": 262.78, "end": 264.88, "word": " فالـ", "probability": 0.8790690104166666}, {"start": 264.88, "end": 265.56, "word": " Digort", "probability": 0.3814697265625}, {"start": 265.56, "end": 266.08, "word": " Syndrome", "probability": 0.77294921875}], "temperature": 1.0}, {"id": 11, "seek": 29369, "start": 267.71, "end": 293.69, "text": "حكينا نتيجة اختلال هذه القطعة بيصير خلل في الـ third و fourth pharyngeal pouches تبعات الـ embryogenesis اللي هم المرحلة المضغة في خلق الإنسان اللي هي محل ما كأنه قطعة البان مأكولة هيك الإنسان بيكون في مرحلة معينة", "tokens": [5016, 4117, 1829, 8315, 8717, 31371, 7435, 3660, 1975, 46456, 1211, 6027, 29538, 25062, 9566, 27884, 4724, 1829, 9381, 13546, 16490, 1211, 1211, 8978, 2423, 39184, 2636, 4032, 6409, 903, 39008, 432, 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"word": " يدور", "probability": 0.7788899739583334}, {"start": 371.25, "end": 372.63, "word": " عليهم", "probability": 0.97607421875}, {"start": 372.63, "end": 373.65, "word": " ده", "probability": 0.43798828125}, {"start": 373.65, "end": 374.51, "word": " مش", "probability": 0.98193359375}, {"start": 374.51, "end": 375.17, "word": " كرموزوم", "probability": 0.7952473958333334}, {"start": 375.17, "end": 375.81, "word": " كامل", "probability": 0.9969075520833334}, {"start": 375.81, "end": 376.97, "word": " باخد", "probability": 0.9363606770833334}, {"start": 376.97, "end": 377.19, "word": " اللي", "probability": 0.953857421875}, {"start": 377.19, "end": 377.73, "word": " بيسموه", "probability": 0.82578125}, {"start": 377.73, "end": 378.81, "word": " Microarray", "probability": 0.59716796875}, {"start": 378.81, "end": 379.33, "word": " و", "probability": 0.333251953125}, {"start": 379.33, "end": 379.65, "word": " لا", "probability": 0.8935546875}, {"start": 379.65, "end": 380.63, "word": " باخد", "probability": 0.9615885416666666}, {"start": 380.63, "end": 381.51, "word": " الـ", "probability": 0.879638671875}, {"start": 381.51, "end": 381.89, "word": " Fish", "probability": 0.403564453125}, {"start": 381.89, "end": 382.57, "word": " اللي", "probability": 0.940185546875}, {"start": 382.57, "end": 382.87, "word": " هو", "probability": 0.98486328125}, {"start": 382.87, "end": 383.87, "word": " Fluorescence", "probability": 0.806640625}, {"start": 383.87, "end": 384.23, "word": " in", "probability": 0.27197265625}, {"start": 384.23, "end": 385.75, "word": " Cytohybridization", "probability": 0.7671875}, {"start": 385.75, "end": 386.51, "word": " يعني", "probability": 0.94873046875}, {"start": 386.51, "end": 387.17, "word": " باخد", "probability": 0.9599609375}, {"start": 387.17, "end": 387.89, "word": " الواحد", "probability": 0.9853515625}, {"start": 387.89, "end": 389.83, "word": " عبارة", "probability": 0.9443359375}, {"start": 389.83, "end": 390.39, "word": " عن", 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بس مش شغال كأنه مش موجود وبالتالي فبتطلع الأمور مقربة", "tokens": [3555, 1829, 30544, 20328, 5016, 2423, 39184, 398, 3714, 29245, 23328, 4724, 3794, 37893, 13412, 17082, 6027, 9122, 33456, 3224, 37893, 3714, 29245, 23328, 46599, 6027, 2655, 6027, 1829, 6156, 3555, 2655, 9566, 1211, 3615, 16247, 2304, 13063, 3714, 4587, 25513, 3660], "avg_logprob": -0.21166423725527386, "compression_ratio": 1.316831683168317, "no_speech_prob": 3.993511199951172e-06, "words": [{"start": 1550.42, "end": 1551.54, "word": "بيكون", "probability": 0.4405110677083333}, {"start": 1551.54, "end": 1551.9, "word": " صح", "probability": 0.8525390625}, {"start": 1551.9, "end": 1552.14, "word": " الـ", "probability": 0.800048828125}, {"start": 1552.14, "end": 1552.26, "word": " Y", "probability": 0.55224609375}, {"start": 1552.26, "end": 1552.9, "word": " موجود", "probability": 0.9820963541666666}, {"start": 1552.9, "end": 1553.2, "word": " بس", "probability": 0.712890625}, {"start": 1553.2, "end": 1553.5, "word": " 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"end": 2628.82, "text": "يعني خلال اللي فيه قرابة بين الأبوين ممكن تكون هي autosomal وليس الـ X-linked process لو X-linked كان الذكور مصابين الإناف غير مصابات بس بما أنه فيه ذكور وإناف معناته مشكلة بهذا الشكل", "tokens": [40228, 22653, 16490, 1211, 6027, 13672, 1829, 8978, 3224, 12174, 2288, 16758, 3660, 49374, 16247, 3555, 2407, 9957, 3714, 43020, 6055, 30544, 39896, 1476, 329, 298, 304, 4032, 20292, 3794, 2423, 39184, 1783, 12, 22473, 292, 1399, 45164, 1783, 12, 22473, 292, 25961, 32545, 4117, 13063, 3714, 9381, 16758, 9957, 33688, 8315, 5172, 32771, 13546, 3714, 9381, 16758, 9307, 4724, 3794, 4724, 15042, 14739, 3224, 8978, 3224, 29910, 4117, 13063, 4032, 28814, 8315, 5172, 20449, 8315, 47395, 37893, 28820, 3660, 39627, 15730, 25124, 28820], "avg_logprob": -0.19319852871053358, "compression_ratio": 1.6149732620320856, "no_speech_prob": 8.940696716308594e-07, "words": [{"start": 2608.92, "end": 2609.52, "word": "يعني", "probability": 0.54522705078125}, {"start": 2609.52, "end": 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4100.7, "word": " second", "probability": 0.96337890625}, {"start": 4100.7, "end": 4101.2, "word": " degree", "probability": 0.97216796875}, {"start": 4101.2, "end": 4101.76, "word": " relative", "probability": 0.9619140625}, {"start": 4101.76, "end": 4103.62, "word": " ماشي", "probability": 0.8302408854166666}, {"start": 4103.62, "end": 4104.82, "word": " ال", "probability": 0.73583984375}, {"start": 4104.82, "end": 4105.4, "word": " ..", "probability": 0.47607421875}, {"start": 4105.4, "end": 4106.18, "word": " بالنسبة", "probability": 0.99072265625}, {"start": 4106.18, "end": 4106.48, "word": " لل", "probability": 0.859375}, {"start": 4106.48, "end": 4106.86, "word": " third", "probability": 0.7724609375}, {"start": 4106.86, "end": 4107.2, "word": " degree", "probability": 0.97900390625}, {"start": 4107.2, "end": 4107.64, "word": " relative", "probability": 0.970703125}, {"start": 4107.64, "end": 4107.86, "word": " يعني", "probability": 0.94189453125}, {"start": 4107.86, "end": 4108.06, "word": " كل", "probability": 0.9912109375}, {"start": 4108.06, "end": 4108.18, "word": " ما", "probability": 0.8681640625}, {"start": 4108.18, "end": 4108.72, "word": " ببعد", "probability": 0.8684895833333334}], "temperature": 1.0}, {"id": 162, "seek": 413649, "start": 4109.69, "end": 4136.49, "text": "درجة بثير باعتبره درجة القرابة وقوة التطابق في المادة الوراثية يعني ماشي فمن الأشياء اللي يعني هيك بشكل واضح منديلية", "tokens": [3215, 47341, 3660, 4724, 12984, 13546, 4724, 995, 34268, 26890, 3224, 11778, 47341, 3660, 25062, 2288, 16758, 3660, 4032, 4587, 2407, 3660, 16712, 9566, 16758, 4587, 8978, 9673, 18513, 3660, 2423, 13063, 5718, 104, 10632, 37495, 22653, 3714, 33599, 1829, 6156, 27842, 16247, 8592, 1829, 16606, 13672, 1829, 37495, 22653, 39896, 4117, 4724, 8592, 28820, 4032, 46958, 5016, 9154, 16254, 1211, 10632], "avg_logprob": -0.19010417234329952, "compression_ratio": 1.6259541984732824, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 4109.69, "end": 4110.41, "word": "درجة", "probability": 0.7705078125}, {"start": 4110.41, "end": 4111.51, "word": " بثير", "probability": 0.5943603515625}, {"start": 4111.51, "end": 4113.31, "word": " باعتبره", "probability": 0.73505859375}, {"start": 4113.31, "end": 4113.83, "word": " درجة", "probability": 0.9529622395833334}, {"start": 4113.83, "end": 4116.37, "word": " القرابة", "probability": 0.8834228515625}, {"start": 4116.37, "end": 4117.51, "word": " وقوة", "probability": 0.8160400390625}, {"start": 4117.51, "end": 4119.27, "word": " التطابق", "probability": 0.992431640625}, {"start": 4119.27, "end": 4119.55, "word": " في", "probability": 0.83447265625}, {"start": 4119.55, "end": 4120.81, "word": " المادة", "probability": 0.9767252604166666}, {"start": 4120.81, "end": 4121.57, "word": " الوراثية", "probability": 0.97978515625}, {"start": 4121.57, "end": 4121.91, "word": " يعني", "probability": 0.653076171875}, {"start": 4121.91, "end": 4123.25, "word": " ماشي", "probability": 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B", "tokens": [6027, 5172, 9381, 26895, 3660, 32748, 2304, 2423, 39184, 13838, 46, 3390, 1594, 9673, 33599, 1829, 2423, 39184, 13838, 46, 3390, 1594, 5296, 15042, 8717, 2655, 4117, 19528, 15844, 3714, 14851, 2407, 7578, 2423, 39184, 3632, 13108, 37495, 22653, 15844, 3714, 14851, 2407, 7578, 16247, 20292, 1211, 11622, 9673, 29245, 23328, 3660, 8978, 2423, 39184, 8272, 13672, 1829, 3714, 29245, 23328, 3660, 8978, 23758, 2423, 39184, 450, 1149, 39894, 15040, 38436, 42963, 33753, 2304, 6027, 9307, 8978, 38637, 1211, 5718, 104, 5551, 20292, 1211, 11622, 12399, 2423, 39184, 422, 16070, 39184, 316, 16070, 39184, 363], "avg_logprob": -0.1595052044528226, "compression_ratio": 1.8412698412698412, "no_speech_prob": 5.364418029785156e-07, "words": [{"start": 4137.01, "end": 4138.31, "word": "الفصيلة", "probability": 0.744775390625}, {"start": 4138.31, "end": 4138.67, "word": " الدم", "probability": 0.953125}, {"start": 4138.67, "end": 4138.85, "word": " الـ", "probability": 0.8662109375}, 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4183.85, "end": 4184.31, "word": " AB", "probability": 0.95263671875}, {"start": 4184.31, "end": 4185.29, "word": " فيه", "probability": 0.78515625}, {"start": 4185.29, "end": 4185.43, "word": " Co", "probability": 0.5576171875}, {"start": 4185.43, "end": 4186.13, "word": "-dominant", "probability": 0.8870849609375}, {"start": 4186.13, "end": 4186.99, "word": " يعني", "probability": 0.93701171875}, {"start": 4186.99, "end": 4187.87, "word": " هذه", "probability": 0.3857421875}, {"start": 4187.87, "end": 4188.41, "word": " مبدأ", "probability": 0.90576171875}, {"start": 4188.41, "end": 4188.63, "word": " إن", "probability": 0.6787109375}, {"start": 4188.63, "end": 4189.07, "word": " أثنين", "probability": 0.69757080078125}, {"start": 4189.07, "end": 4190.31, "word": " أقوياء", "probability": 0.9156494140625}, {"start": 4190.31, "end": 4191.25, "word": " وظاهرين", "probability": 0.90126953125}, {"start": 4191.25, "end": 4192.47, "word": " أثنينهم", "probability": 0.9189453125}, {"start": 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{"start": 4396.34, "end": 4396.58, "word": " على", "probability": 0.91064453125}, {"start": 4396.58, "end": 4396.84, "word": " كل", "probability": 0.9892578125}, {"start": 4396.84, "end": 4397.56, "word": " حالة", "probability": 0.751708984375}, {"start": 4397.56, "end": 4397.82, "word": " الله", "probability": 0.271240234375}, {"start": 4397.82, "end": 4398.06, "word": " يعطيك", "probability": 0.7862548828125}, {"start": 4398.06, "end": 4398.18, "word": " الخير", "probability": 0.66552734375}, {"start": 4398.18, "end": 4398.28, "word": " يا", "probability": 0.97021484375}, {"start": 4398.28, "end": 4398.6, "word": " دكتور", "probability": 0.9739990234375}, {"start": 4398.6, "end": 4399.06, "word": " الله", "probability": 0.487548828125}, {"start": 4399.06, "end": 4399.24, "word": " يعطيك", "probability": 0.80694580078125}, {"start": 4399.24, "end": 4399.38, "word": " الخير", "probability": 0.700927734375}, {"start": 4399.38, "end": 4399.38, "word": " يا", "probability": 0.52685546875}, {"start": 4399.38, "end": 4399.96, "word": " دكتور", "probability": 0.9471435546875}, {"start": 4399.96, "end": 4399.96, "word": " الله", "probability": 0.60205078125}, {"start": 4399.96, "end": 4400.1, "word": " يعطيك", "probability": 0.7996826171875}, {"start": 4400.1, "end": 4400.1, "word": " الخير", "probability": 0.91064453125}, {"start": 4400.1, "end": 4400.1, "word": " يا", "probability": 0.84521484375}, {"start": 4400.1, "end": 4400.1, "word": " دكتور", "probability": 0.9869384765625}, {"start": 4400.1, "end": 4400.34, "word": " الله", "probability": 0.7529296875}, {"start": 4400.34, "end": 4400.64, "word": " يعطيك", "probability": 0.9146728515625}, {"start": 4400.64, "end": 4400.64, "word": " الخير", "probability": 0.9560546875}, {"start": 4400.64, "end": 4400.64, "word": " يا", "probability": 0.92919921875}, {"start": 4400.64, "end": 4400.64, "word": " دكتور", "probability": 0.99609375}, {"start": 4400.64, "end": 4400.64, "word": " الله", "probability": 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0.986328125}, {"start": 4400.9, "end": 4400.9, "word": " يا", "probability": 0.953125}, {"start": 4400.9, "end": 4400.9, "word": " دكتور", "probability": 0.99755859375}, {"start": 4400.9, "end": 4400.9, "word": " الله", "probability": 0.767578125}, {"start": 4400.9, "end": 4400.9, "word": " يعطيك", "probability": 0.9783935546875}, {"start": 4400.9, "end": 4400.9, "word": " الخير", "probability": 0.9873046875}, {"start": 4400.9, "end": 4400.9, "word": " يا", "probability": 0.9462890625}, {"start": 4400.9, "end": 4400.9, "word": " دكتور", "probability": 0.99755859375}, {"start": 4400.9, "end": 4400.9, "word": " الله", "probability": 0.78564453125}, {"start": 4400.9, "end": 4400.9, "word": " يعطيك", "probability": 0.980224609375}, {"start": 4400.9, "end": 4400.9, "word": " الخير", "probability": 0.98779296875}, {"start": 4400.9, "end": 4400.96, "word": " يا", "probability": 0.93798828125}, {"start": 4400.96, "end": 4400.96, "word": " دكتور", "probability": 0.99755859375}, {"start": 4400.96, "end": 4401.16, "word": " الله", "probability": 0.80419921875}, {"start": 4401.16, "end": 4401.16, "word": " يعطيك", "probability": 0.9814453125}, {"start": 4401.16, "end": 4401.16, "word": " الخير", "probability": 0.988037109375}, {"start": 4401.16, "end": 4401.16, "word": " يا", "probability": 0.92822265625}, {"start": 4401.16, "end": 4401.16, "word": " دكتور", "probability": 0.9971923828125}, {"start": 4401.16, "end": 4401.26, "word": " الله", "probability": 0.83837890625}, {"start": 4401.26, "end": 4401.66, "word": " يعطيك", "probability": 0.982666015625}, {"start": 4401.66, "end": 4402.22, "word": " الخير", "probability": 0.987548828125}, {"start": 4402.22, "end": 4402.84, "word": " يا", "probability": 0.91162109375}, {"start": 4402.84, "end": 4402.88, "word": " دكتور", "probability": 0.996826171875}, {"start": 4402.88, "end": 4402.88, "word": " الله", "probability": 0.8828125}, {"start": 4402.88, "end": 4402.88, "word": " يعطيك", "probability": 0.9825439453125}, {"start": 4402.88, "end": 4402.9, "word": " الخير", "probability": 0.98681640625}, {"start": 4402.9, "end": 4403.08, "word": " يا", "probability": 0.90234375}, {"start": 4403.08, "end": 4403.34, "word": " دكتور", "probability": 0.9964599609375}, {"start": 4403.34, "end": 4403.34, "word": " الله", "probability": 0.91357421875}, {"start": 4403.34, "end": 4403.34, "word": " يعطيك", "probability": 0.9832763671875}, {"start": 4403.34, "end": 4403.36, "word": " الخير", "probability": 0.986328125}, {"start": 4403.36, "end": 4404.16, "word": " يا", "probability": 0.8984375}, {"start": 4404.16, "end": 4404.16, "word": " دكتور", "probability": 0.9962158203125}, {"start": 4404.16, "end": 4404.16, "word": " الله", "probability": 0.9384765625}, {"start": 4404.16, "end": 4404.44, "word": " يعطيك", "probability": 0.9842529296875}, {"start": 4404.44, "end": 4404.44, "word": " الخير", "probability": 0.98486328125}, {"start": 4404.44, "end": 4404.44, "word": " يا", "probability": 0.884765625}, {"start": 4404.44, "end": 4404.8, "word": " دكتور", "probability": 0.99560546875}, {"start": 4404.8, "end": 4405.04, "word": " الله", "probability": 0.943359375}, {"start": 4405.04, "end": 4405.2, "word": " يعطيك", "probability": 0.98486328125}, {"start": 4405.2, "end": 4405.56, "word": " الخير", "probability": 0.980224609375}, {"start": 4405.56, "end": 4405.8, "word": " يا", "probability": 0.78173828125}, {"start": 4405.8, "end": 4405.8, "word": " دكت", "probability": 0.9934895833333334}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 4407.5885625, "duration_after_vad": 4307.98999999998}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/QjHQ6ziYtVc.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/QjHQ6ziYtVc.srt
new file mode 100644
index 0000000000000000000000000000000000000000..5510029b2587e4fe7e34432ebf9a32bb7037e6c3
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/QjHQ6ziYtVc.srt
@@ -0,0 +1,2954 @@
+1
+00:00:00,000 --> 00:00:07,320
+بسم الله الرحمن الرحيم. في المحاضرة السابقة كنا
+
+2
+00:00:07,320 --> 00:00:15,780
+نتكلم عن تركيب الـ DNA والمادة الوراثية، وكيف هي
+
+3
+00:00:15,780 --> 00:00:24,980
+موجودة في خلايانا، ووصلنا ووقفنا شوية عند هذه
+
+4
+00:00:24,980 --> 00:00:29,840
+الصورة، وتناقشنا فيها شوية، اللي هي يعني حاطين فيها
+
+5
+00:00:29,840 --> 00:00:36,520
+مبادئ أن داخل الـ Chromosome بيكون الـ DNA على
+
+6
+00:00:36,520 --> 00:00:41,920
+شكل اللي هو الـ Double Helix، السلم اللولبي، وأن
+
+7
+00:00:41,920 --> 00:00:48,360
+لما نحن نيجي نتعامل معه، دائماً نأخذ الأصل اللي
+
+8
+00:00:48,360 --> 00:00:53,630
+يكون اللي هو القطعة اللي ماشية من الجهة الـ Five
+
+9
+00:00:53,630 --> 00:00:58,150
+Prime إلى Three Prime، يعني بترتيب معين طبعاً، لأن
+
+10
+00:00:58,150 --> 00:01:03,710
+الـ Double Helix، درجاته عبارة عن الـ Purine
+
+11
+00:01:03,710 --> 00:01:07,870
+والـ Pyrimidine، نوعين من القواعد النيتروجينية،
+
+12
+00:01:07,870 --> 00:01:15,110
+وبالتالي كل واحد يرتبط مع نوع آخر محدد، يعني في
+
+13
+00:01:15,110 --> 00:01:21,390
+أي موقع بكون أنا عندي أربع احتمالات: الـ C، والـ G،
+
+14
+00:01:21,390 --> 00:01:27,660
+والـ A، والـ T، وبالتالي المكافئ
+
+15
+00:01:27,660 --> 00:01:33,960
+له بيكون محدداً، بطريقة محددة، فالـصورة
+
+16
+00:01:33,960 --> 00:01:41,660
+هذه سببت إشكالية شوية، اللي هي أننا لما نتعامل
+
+17
+00:01:41,660 --> 00:01:47,760
+مع الـ DNA، ومن هذول الأحرف الأربعة، الواحد من
+
+18
+00:01:47,760 --> 00:01:53,000
+الأربعة، إنه ثلاثة، أقصد تسعة، ثلاثة في عشر، أقصد تسعة
+
+19
+00:01:53,000 --> 00:01:57,680
+وتلات مليارات نيوكليوتيد
+
+20
+00:01:57,680 --> 00:02:05,150
+(bases) أو Nucleotides، وبكونوا لما نتعامل معها في
+
+21
+00:02:05,150 --> 00:02:13,490
+حالات قراءتها، في القراءات، في الـ... في أي خلية أو
+
+22
+00:02:13,490 --> 00:02:16,870
+في خلية إنسان معين، زي ما سوينا في الـ Human
+
+23
+00:02:16,870 --> 00:02:23,030
+Genome، طلعنا ما يسمى في أي موقع معين، في جين معين
+
+24
+00:02:23,030 --> 00:02:26,790
+أنا مهتم فيه، بقول، بطلع الـ Reference Sequence،
+
+25
+00:02:26,790 --> 00:02:32,080
+وهذا اللي بأعتمد عليه من خلال الـ Human Genome Project.
+
+26
+00:02:32,080 --> 00:02:38,000
+هذا بأعتبره المرجع بالنسبة لي، فإذا أنا بأعمل دراسة
+
+27
+00:02:38,000 --> 00:02:42,780
+معينة، وهي فرضية أو افتراض، في حالة معينة، أن أنا
+
+28
+00:02:42,780 --> 00:02:47,160
+جيت أركز بسبب المرض، أو الحالة، أو الشيء اللي أنا
+
+29
+00:02:47,160 --> 00:02:53,480
+بدرسه فيه، جيت درست مجموعة أشخاص، الشخص الأول، صدفة
+
+30
+00:02:53,480 --> 00:02:56,900
+هيك، أو طلع معه، إنه طلعت تماماً زي الـ Reference
+
+31
+00:02:56,900 --> 00:03:02,630
+Sequence، وكان هذا الشخص الأول. في الشخص الثاني
+
+32
+00:03:02,630 --> 00:03:07,550
+والثالث، كان فيه تبديل في أحد القواعد النيتروجينية،
+
+33
+00:03:07,550 --> 00:03:11,890
+وهذا بيصير، ومش كل الناس زي بعض، عشان هيك نحن
+
+34
+00:03:11,890 --> 00:03:19,350
+مختلفين، فبتلاقوا الواحد في الموقع هذا، بدل ما هي
+
+35
+00:03:19,350 --> 00:03:25,850
+جاي T، صار C، نيوكليوتيد أو nitrogenous base، فهذا
+
+36
+00:03:25,850 --> 00:03:32,150
+إنسان مختلف بشكل بسيط، حتى بيسموهم SNPs، Single
+
+37
+00:03:32,150 --> 00:03:37,270
+Nucleotide Polymorphisms، يعني أن فيه اختلاف في
+
+38
+00:03:37,270 --> 00:03:41,770
+حرف واحد من الأحرف الأربعة، في موقع معين، والشخص
+
+39
+00:03:41,770 --> 00:03:46,810
+الثاني والثالث في هذا الموقع متشابهين. الشخص الرابع
+
+40
+00:03:46,810 --> 00:03:52,690
+في عنده تبديل آخر، في موقع آخر، في حرف آخر، ممكن تحدث
+
+41
+00:03:52,690 --> 00:03:59,140
+بهذه الطريقة. والشخص الخامس كان عنده أن طول الـ DNA
+
+42
+00:03:59,140 --> 00:04:03,800
+في هذا الموقع أقصر، بحيث أن صار فيه إزالة لنوعين.
+
+43
+00:04:03,800 --> 00:04:11,740
+وهذه يعني كأنها تمثل نوع من، يعني لما يجي الطبيب أو
+
+44
+00:04:11,740 --> 00:04:16,700
+العالم أو الباحث، يجي يدرس موقع معين لمرض معين أو
+
+45
+00:04:16,700 --> 00:04:21,000
+لحالة معينة، ويدرس مجموعة من البشر، ويلاقي هذه
+
+46
+00:04:21,000 --> 00:04:26,960
+الاختلافات بهذا الشكل، لا تعني شيء، يعني من ناحية
+
+47
+00:04:26,960 --> 00:04:32,300
+الآن، أن نأخذها أن هذا يمثل مرض، أو نتيجتها كذا أو
+
+48
+00:04:32,300 --> 00:04:39,700
+كذا، يعني، بس بقدر ما إنها هي أمثلة لطريق
+
+49
+00:04:39,700 --> 00:04:45,180
+دراسة الـ DNA في الأيام الحالية، أن دائماً نستخدم الـ
+
+50
+00:04:45,180 --> 00:04:51,710
+PCR، بحيث أن نطلع شو الترتيب الحالي للأحرف تبعات
+
+51
+00:04:51,710 --> 00:05:00,210
+الـ Nucleotides أو الـ DNA، وكذلك النقطة اللي بعدها،
+
+52
+00:05:00,210 --> 00:05:03,610
+أن
+
+53
+00:05:03,610 --> 00:05:09,210
+22 أو 23 زوج من الكروموزومات، 22 متشابهة جسمية،
+
+54
+00:05:09,210 --> 00:05:18,210
+تقريباً، يعني حسب الـ Graph هذا، كل ما، يعني هو
+
+55
+00:05:18,210 --> 00:05:26,150
+تقريباً ذكرنا فيه حوالي 25 ألف جين،
+
+56
+00:05:26,150 --> 00:05:32,050
+في الـ Human Genome، هذا تقديرهم حسب الـ Human Genome
+
+57
+00:05:32,050 --> 00:05:37,830
+Project، فتقريباً أن الإنسان يقدر أن في كل
+
+58
+00:05:37,830 --> 00:05:42,390
+كروموزوم فيه حوالي ألف تقريباً، بس فيه تفاوض شديد،
+
+59
+00:05:42,390 --> 00:05:48,100
+يعني الكروموزوم رقم واحد، يعني بنلاقي في آخر الـ
+
+60
+00:05:48,100 --> 00:05:53,380
+جدول، الـ Graph هذا، في أعلى شيء، حجمه أكبر شيء،
+
+61
+00:05:53,380 --> 00:05:59,900
+حوالي 250 ميجابايز، يعني مليون قاعدة بهذا الشكل،
+
+62
+00:05:59,900 --> 00:06:07,960
+ويقدر أن فيه حوالي 2000 جين، عدد الجينات أو القطع،
+
+63
+00:06:07,960 --> 00:06:15,610
+اللي تتحول إلى بروتين. فهكذا ترتيب وتوزيع الـ... الـ...
+
+64
+00:06:15,610 --> 00:06:22,170
+الكروموزومات تبع الـ DNA في النواة، وطبعاً بنلاحظ،
+
+65
+00:06:22,170 --> 00:06:27,010
+أن في الـ X والـ Y، كروموزومات الـ X هو الأكبر، واللي
+
+66
+00:06:27,010 --> 00:06:36,190
+فيه جينات أكثر. الـ Y فقير للجينات، يعني حوالي ممكن
+
+67
+00:06:36,190 --> 00:06:41,890
+خمسين جين، أو عدد قليل من الجينات، وهذه تمت دراستها
+
+68
+00:06:41,890 --> 00:06:42,510
+سابقاً.
+
+69
+00:06:45,000 --> 00:06:50,340
+محاضرة الإستكمال، محاضرة اليوم، نبدأ بوصف الظواهر
+
+70
+00:06:50,340 --> 00:06:56,660
+اللي بتحدث، نتيجة تكاثر الجسم، وتكون الإنسان،
+
+71
+00:06:56,660 --> 00:07:02,940
+انطلاقاً من خلية واحدة، اللي هي الـ Fertilized Egg، من
+
+72
+00:07:02,940 --> 00:07:08,280
+أولها إلى آخر يوم في حياته، يكون هناك انقسام في
+
+73
+00:07:08,280 --> 00:07:12,120
+الخلايا، وهناك نوعين من الانقسام، وكلها معلومات
+
+74
+00:07:12,120 --> 00:07:18,430
+تعرفوها. إذا في حد عنده أي استفسار يوقفني، وإذا
+
+75
+00:07:18,430 --> 00:07:24,390
+الأمور واضحة، بنكمل. الانقسام
+
+76
+00:07:24,390 --> 00:07:31,530
+على نوعين، فيه الانقسام الخلوي، أو الانقسام اللي
+
+77
+00:07:31,530 --> 00:07:36,330
+هو الـ Mitotic باللغة الإنجليزية، وهناك الـ Meiosis،
+
+78
+00:07:36,330 --> 00:07:42,430
+اللي هو الانقسام المنصف. فالانقسام للخلايا العادية
+
+79
+00:07:43,250 --> 00:07:50,590
+بكون أنهم، يعني توصف بأنها تمر في cell cycle، في
+
+80
+00:07:50,590 --> 00:07:58,230
+دورة حياة الخلية، فإنها تكون تؤدي وظائفها، وتعمل حسب
+
+81
+00:07:58,230 --> 00:08:04,770
+أنواع مختلفة من الخلايا، بتكون بالـ G1 phase، يعني
+
+82
+00:08:04,770 --> 00:08:08,570
+اللي هي في مرحلة أنها تكون خلية عادية، تقوم
+
+83
+00:08:08,570 --> 00:08:11,530
+بوظيفتها حسب الشيء المطلوب منها.
+
+84
+00:08:14,460 --> 00:08:22,280
+النواة بيكون المادة الوراثية فيها زي الخيط الطويل،
+
+85
+00:08:22,280 --> 00:08:29,660
+وما في داعي يكون مربوط أو مكور بشكل مضغوط، حتى يتم
+
+86
+00:08:29,660 --> 00:08:37,380
+عملية الانقسام. عند حدوث أو تهيؤ لبداية الانقسام،
+
+87
+00:08:39,710 --> 00:08:48,090
+بتتم، يعني بعد ما تكون في حالة الـ G1، تدخل في المرحلة
+
+88
+00:08:48,090 --> 00:08:53,350
+ما تسمى الـ S phase، وهي المرحلة اللي يتم فيها إعادة
+
+89
+00:08:53,350 --> 00:09:01,550
+أو مضاعفة، تكوين الـ DNA والكروموزومات بشكل كامل، بحيث
+
+90
+00:09:01,550 --> 00:09:06,330
+أن تصبح للخلية نسختين من المادة الوراثية، الـ
+
+91
+00:09:06,330 --> 00:09:12,830
+Chromosome، يعني بشكل مهم، حتى يشترك في هذه العملية،
+
+92
+00:09:12,830 --> 00:09:20,970
+بيكون يصبح على شكل مضغوط، ويكون على شكل يعني قطعة
+
+93
+00:09:20,970 --> 00:09:27,550
+الـ الـ الـ DNA الملفوف بشكل شديد ومضغوط، وله
+
+94
+00:09:27,550 --> 00:09:34,640
+حتى يتم فصله على جهتين الخليتين المتفصلتين، بعدين بيكون
+
+95
+00:09:34,640 --> 00:09:41,580
+عنده Centromere، اللي هو النقطة عليه التي يتم جذب
+
+96
+00:09:41,580 --> 00:09:50,420
+الكروموزومين المتشابهين إلى زاويتي خليتين متكونتين
+
+97
+00:09:50,420 --> 00:09:55,100
+جديدتين. فالـ Centromere هذا، وظيفته بيشبك مع الـ
+
+98
+00:09:55,100 --> 00:09:58,970
+Spindle  للـ Centrosomes على الجوانب. وهناك ما
+
+99
+00:09:58,970 --> 00:10:06,130
+يسمى التيلومير، التيلومير هي يعني بدك تشبهها بمسبحة
+
+100
+00:10:06,130 --> 00:10:13,310
+على طرف ونهاية الكروموزومات. التيلومير، حد بيقدر يقول
+
+101
+00:10:13,310 --> 00:10:23,130
+أن، عشان أفهم، أن اللي معي سامعيني واضح، التيلومير
+
+102
+00:10:23,130 --> 00:10:29,420
+إيه، له قصة، يعني... يعني بيجدر الواحد ينتبه
+
+103
+00:10:29,420 --> 00:10:38,280
+لها. الـ Telomere، يعني يقدر، يعني هذا التقدير أن
+
+104
+00:10:38,280 --> 00:10:45,600
+الخلايا، من بداية تكون النطفة المخصبة، أو الـ
+
+105
+00:10:45,600 --> 00:10:50,880
+Fertilized Egg، أن تمتلك حوالي ستين مرة من القدرة
+
+106
+00:10:50,880 --> 00:10:56,870
+على الانقسام. وهذا العدد الانقسامات هذه الستين، اثنين
+
+107
+00:10:56,870 --> 00:11:02,550
+لأس ستين، إذا بتتذكروا قصة اللي اخترع
+
+108
+00:11:02,550 --> 00:11:06,730
+لعبة
+
+109
+00:11:06,730 --> 00:11:12,290
+الشطرنج، أن طلب للملك، طلب الملك، اللي قاله اطلب
+
+110
+00:11:12,290 --> 00:11:18,030
+اللي بدك إياه، وأعطاه إياه بله بسيطة، بدي تحط لي حبة قمح في
+
+111
+00:11:18,030 --> 00:11:24,300
+أول مربع في الـ 64 مربع، وبعدين تحط لي حبتين قمح
+
+112
+00:11:24,300 --> 00:11:29,660
+بالمربع الثاني، أو أربع حبات، ويضاعف كل مرة، فثبت أن
+
+113
+00:11:29,660 --> 00:11:34,820
+يعني كل إنتاج العالم من القمح، لن يكفي لتغطية هذا
+
+114
+00:11:34,820 --> 00:11:40,740
+الطلب. فـ 60 انقسام، يعني كمية مهولة جداً، ينتج عنها
+
+115
+00:11:40,740 --> 00:11:47,860
+ما بدي أقول مليارات المليارات من الخلايا، فحتى يتم
+
+116
+00:11:47,860 --> 00:11:53,210
+التحكم بهذا الأمر، في نهاية الكروموزوم يكون هناك مثل
+
+117
+00:11:53,210 --> 00:12:00,350
+المسبحة، فيها ستين حبة، بحيث مع كل انقسام، بتطير حبة
+
+118
+00:12:00,350 --> 00:12:04,610
+من المسبحة هذه، بحيث عشان هيك يعني دراسة الـ
+
+119
+00:12:04,610 --> 00:12:12,010
+Telomere، في أول كائن مستنسخ من خلية، يعني جابوها
+
+120
+00:12:12,010 --> 00:12:17,960
+بطريقة مختلفة، اللي هي النعجة دولي، كتبت أن حتى
+
+121
+00:12:17,960 --> 00:12:23,760
+عند ولادتها هي، تقريباً بمثل عمر أمها، بسبب أن الـ
+
+122
+00:12:23,760 --> 00:12:30,460
+Telomere تبعها كان أقصر. فهذا جانب مهم للتحكم
+
+123
+00:12:30,460 --> 00:12:35,780
+في العملية الكلية لقضية انقسام الخلايا في الجسم.
+
+124
+00:12:35,780 --> 00:12:41,340
+فهناك ما يسمى الـ Telomeres. دكتور، بعد إذنك، في
+
+125
+00:12:41,340 --> 00:12:45,760
+سؤال من الدكتور أسديهان، بخصوص وظيفة الـ
+
+126
+00:12:45,760 --> 00:12:53,280
+Centromere. Centromere هو المركز اللي يعني إحنا
+
+127
+00:12:53,280 --> 00:13:01,100
+راح... هون، إذا بتنتبه، الخلية هذه كانت واحدة، تضاعفت
+
+128
+00:13:01,100 --> 00:13:07,500
+الـ DNA اللي فيها، فبعد ذلك انقسمت نصفين إلى خليتين،
+
+129
+00:13:08,350 --> 00:13:12,810
+والسبب في الانقسام، أن هناك راح يكون حاجة نحكي
+
+130
+00:13:12,810 --> 00:13:17,370
+عنها Centrosome، مش Centromere، Centrosome بيكون
+
+131
+00:13:17,370 --> 00:13:23,150
+بالطرف، من الجهتين الخليتين اللي راح يتكونوا، وراح
+
+132
+00:13:23,150 --> 00:13:30,830
+يتم جذب الكروموزومات، أو الكروماتيد، لكل طرف،
+
+133
+00:13:30,830 --> 00:13:35,790
+عن طريق اللي هم يعني الـ Spindle Fibers، بقولوا لهم،
+
+134
+00:13:36,280 --> 00:13:39,620
+وبيشبكوا ما بين الـ Centrosome مع الـ Centromere،
+
+135
+00:13:39,620 --> 00:13:51,280
+حتى يفصل الـ DNA إلى نصفين متساويين، واضحة؟ فالـ
+
+136
+00:13:51,280 --> 00:13:58,420
+Centromere هو قطعة في الـ DNA، في الـ Chromosome،
+
+137
+00:13:58,420 --> 00:14:06,510
+وظيفتها تسهيل والتحكم في عملية فصل نصفي الـ
+
+138
+00:14:06,510 --> 00:14:13,330
+Chromosomes إلى طرفي الخلية المنقسمة، ماشي؟ لسه
+
+139
+00:14:13,330 --> 00:14:16,370
+برضه النقطة يبدو أنها ما واضحة، تقريباً راح نشوفها
+
+140
+00:14:16,370 --> 00:14:21,010
+بعدين بشكل تفصيلي، يعني الآن مش راسمينها، بس راح
+
+141
+00:14:21,010 --> 00:14:26,550
+تيجي مرة ثانية، ماشي؟ راح نشوفها كثير، شيء ضروري
+
+142
+00:14:26,550 --> 00:14:34,030
+عشان نقدر نفصلهم، يعني إذا أنا مثلاً عندي Top 10
+
+143
+00:14:34,030 --> 00:14:40,220
+خيوط، وبدي أفصلهم عن بعض، لازم من مكان معين أمسكهم،
+
+144
+00:14:40,220 --> 00:14:45,040
+عشان أجرهم للجهتين المختلفتين، فهذا المكان في
+
+145
+00:14:45,040 --> 00:14:49,820
+الـ Chromosome هو الـ Centromere، وإله أشياء، وبعدين
+
+146
+00:14:49,820 --> 00:14:58,840
+تاخذوها في الطب السريري، يعني، ماشي، فالآن لما
+
+147
+00:14:58,840 --> 00:15:08,950
+نتكلم على ظواهر أو تسميات أخرى، بتكون الخلايا في الـ
+
+148
+00:15:08,950 --> 00:15:19,170
+G1، يعني هنا الـ G1 حاطينه بهذا الشكل، اللي هو
+
+149
+00:15:19,170 --> 00:15:24,350
+الخلية في المرحلة تبعها، بتمر في مرحلة إحنا ما
+
+150
+00:15:24,350 --> 00:15:28,070
+بنشوفها، اللي هي الـ S-phase، للإستعداد لعملية
+
+151
+00:15:28,070 --> 00:15:34,450
+الانقسام، بتتم فيها عملية إعادة أو مضاعفة كمية
+
+152
+00:15:34,450 --> 00:15:40,950
+الـ DNA، لما يتضاعف، الخلية تصبح لديها ضعف كمية
+
+153
+00:15:40,950 --> 00:15:47,090
+الـ DNA، تبدأ تدخل في عملية الانقسام. فالانقسام يتم
+
+154
+00:15:47,090 --> 00:15:52,430
+في مرحلة الـ G2، أو بعد ما تدخل الـ G2، بتكتر شوية،
+
+155
+00:15:52,430 --> 00:15:58,130
+تبدأ تدخل في الـ Mitosis، الـ Mitosis اللي هو
+
+156
+00:15:58,130 --> 00:16:04,500
+الانقسام الطبيعي، بتبدأ بالـ Interphase، تدخل بالـ
+
+157
+00:16:04,500 --> 00:16:07,480
+Prophase، وبعدين Pro-Metaphase، Metaphase،
+
+158
+00:16:07,480 --> 00:16:13,060
+Anaphase، Telophase، وبعدين Cytokinesis، تنقسم
+
+159
+00:16:13,060 --> 00:16:21,660
+شوية المراحل، بدنا نشوف الظواهر التالية. هنا صار
+
+160
+00:16:21,660 --> 00:16:28,120
+عندي ضعف كمية الـ DNA، فلما تبدأ عملية الانقسام،
+
+161
+00:16:28,120 --> 00:16:35,690
+أول شيء الـ Centrosomes تظهر، يعني بتتكور بشكل أقوى،
+
+162
+00:16:35,690 --> 00:16:42,710
+وأوضح، بدي إثنين منهم. الخطوة التالية، أن بعد ما
+
+163
+00:16:42,710 --> 00:16:50,610
+كان الخيط أو الـ DNA طويل، وطويل وغير ظاهر داخل
+
+164
+00:16:50,610 --> 00:17:00,010
+النواة، يتم تكتيفه، والتواءه على بعض، بحيث يكون الـ
+
+165
+00:17:00,010 --> 00:17:03,870
+Chromatids والـ Chromosomes، بالشكل اللي بنشوفه،
+
+166
+00:17:03,870 --> 00:17:09,590
+هنا، لما يبدأ يظهروا، تبدأ أن الخلية هذه مستعدة
+
+167
+00:17:09,590 --> 00:17:14,290
+لعملية الانقسام، وتسمى هذه مرحلة الـ Prophase. بيصير
+
+168
+00:17:14,290 --> 00:17:19,330
+أن الـ Centrosome يظهر، الـ Chromatin أو الـ
+
+169
+00:17:19,330 --> 00:17:25,050
+Chromosomes تظهر، بعد ما كانت الخيوط مفروقة، بتصير
+
+170
+00:17:25
+
+223
+00:22:47,450 --> 00:22:55,830
+أنها «2N» لأنه في نسختين، فالـ طبعاً نسختين،
+
+224
+00:22:55,830 --> 00:23:02,110
+نصفها من الأب ونصفها من الأم، حتى يتم عملية الإنقسام
+
+225
+00:23:02,110 --> 00:23:08,510
+بدها تظهر خلية البنت أو الناتجة تماثل تمامًا
+
+226
+00:23:08,510 --> 00:23:14,570
+الخلية الأم، تبعتها. فحتى يتم هذا الأمر لازم في لحظة
+
+227
+00:23:14,570 --> 00:23:21,430
+معينة يتم عملية تكتير الـDNA، يعني مضاعفته، اللي هي
+
+228
+00:23:21,430 --> 00:23:24,890
+الـS-phase. فاحنا بنكون بالـG1 phase، هي الخلية
+
+229
+00:23:24,890 --> 00:23:33,370
+العادية، الـDNA لما نحكي عنها 46 كروموزوم، DNA كامل.
+
+230
+00:23:33,370 --> 00:23:38,350
+بالوصف اللي بنصفه إحنا بنكون نصف الـ DNA تبع هذه
+
+231
+00:23:38,350 --> 00:23:44,230
+المرحلة. فحتى يتم عملية الإنقسام لازم بالأول يتم
+
+232
+00:23:44,230 --> 00:23:49,370
+عملية مضاعفة الـ DNA. ففي الـ G2 الخلية في هذه
+
+233
+00:23:49,370 --> 00:23:54,450
+المرحلة بكون ضاعفت الـ DNA تبعتها، فصار 4N
+
+234
+00:23:54,450 --> 00:24:01,510
+فصار عندها أربعة أضعاف كمية الـ DNA، يعني من المفردة
+
+235
+00:24:01,510 --> 00:24:06,810
+اللي هي راح نشوف موجودة في الـ Sperms والـ Eggs
+
+236
+00:24:06,810 --> 00:24:14,810
+اللي هما في الانقسام الثاني. فهو نتوءًا، الـ S
+
+237
+00:24:14,810 --> 00:24:21,230
+بضاعف الـ DNA، بنقسم في الـ Mitosis بهذه الطريقة،
+
+238
+00:24:21,230 --> 00:24:27,960
+برجع توءامه. هذه المصطلحات اللي بيستخدمها لكمية الـ
+
+239
+00:24:27,960 --> 00:24:34,140
+DNA اللي موجودة، واضح؟ في سؤال آخر يا دكتور بخصوص
+
+240
+00:24:34,140 --> 00:24:41,040
+الـ نعم، اللي هو الـ microtubule، الشو بتفرج عن الـ
+
+241
+00:24:41,040 --> 00:24:45,360
+spindle fiber؟ هم spindle fiber هم نفسهم، هم
+
+242
+00:24:45,360 --> 00:24:50,220
+نفسهم، عبارة عن يعني بالأخير أكتين وميوسين، يعني
+
+243
+00:24:50,220 --> 00:24:57,590
+زي العضلات، إيش عشان يجد؟ عشان يعني يخلّي الخلية
+
+244
+00:24:57,590 --> 00:25:04,810
+تنقسم، لأن الـ DNA ينقسم، ففي خيوط تبدأ من الـ
+
+245
+00:25:04,810 --> 00:25:11,630
+Centrosome على الطرف، تصل لـ Centromere في نص الـ
+
+246
+00:25:11,630 --> 00:25:19,720
+Chromosome حتى تشده لطرفين، ماشي؟ في برضه سؤال من
+
+247
+00:25:19,720 --> 00:25:27,020
+عمر بخصوص يعني إنه عدد الـN، يعني الـ A's، بقول حرف
+
+248
+00:25:27,020 --> 00:25:31,960
+الـN بيمثل عدد الـDNA ولا كمية الكروموسومات؟ كمية
+
+249
+00:25:31,960 --> 00:25:38,400
+الكروموسومات، هيك بعتبرهم على أساس نربطهم لبعض، one
+
+250
+00:25:38,400 --> 00:25:45,200
+N اللي موجود في الـ sperm أو في الـ egg، راح ناخده
+
+251
+00:25:45,200 --> 00:25:49,520
+بعد شوية. في الخلية العادية اللي بتقوم في الشغل،
+
+252
+00:25:49,520 --> 00:25:54,600
+بكون عندي «2N»، بس بعد ما تخلص الـ «S» تدخل، بتكون
+
+253
+00:25:54,600 --> 00:25:58,560
+أنها في مرحلة «4N»، اللي هي بالـ «G2»، وبعدين
+
+254
+00:25:58,560 --> 00:26:02,940
+بتسوي عملية الإنقسام. فهو بعينك بيقول، يعني هل لما
+
+255
+00:26:02,940 --> 00:26:08,640
+تصير «4N»، بيصير عدد الأزواج يعني 64 زوج؟ آه،
+
+256
+00:26:08,640 --> 00:26:12,400
+نعم، لأ، شو 64؟ لأ، مش 64، أنا استغربت من السؤال،
+
+257
+00:26:12,400 --> 00:26:17,370
+لأ، 46 زوج، صحيح؟ 46 زوج بدأت تضربهم بـ2 كمان، يعني
+
+258
+00:26:17,370 --> 00:26:24,310
+تصير 92 زوج، صحيح، واضح يا طارق إن شاء الله بخصوص
+
+259
+00:26:24,310 --> 00:26:29,970
+السؤال اللي سألته الآن.
+
+260
+00:26:29,970 --> 00:26:36,310
+من التجارب اللي أجرتها وكنت أسويها زمان وإحنا طلاب،
+
+261
+00:26:36,310 --> 00:26:40,530
+حتى إذا كان عندنا مجال نعملها، اللي هو فحص بهذا
+
+262
+00:26:40,530 --> 00:26:48,740
+الشكل، بنسميه الـ Karyotype. الـ Karyotype إنه أول
+
+263
+00:26:48,740 --> 00:26:53,460
+شيء إحنا يعني
+
+264
+00:26:53,460 --> 00:26:58,000
+بنعطي الدواء اللي هو الـ Colchicine، لحيث أنه يخرب الـ
+
+265
+00:26:58,000 --> 00:27:04,180
+Spindle Fibers. وفي حالة ما، ناخد الخلايا في مرحلة
+
+266
+00:27:04,180 --> 00:27:10,280
+يعني أنا بعطي شيء بيوقف انقسام الخلايا، ماشي، من إنه
+
+267
+00:27:10,280 --> 00:27:13,320
+بيخرب الـ Spindle Fibers أو الـ Microtubules،
+
+268
+00:27:13,320 --> 00:27:19,100
+فبتوصل الخلية لمرحلة الـ Metaphase اللي بيكون في
+
+269
+00:27:19,100 --> 00:27:25,980
+الـ DNA على شكل، أكبر شكل مضغوط فيه. فأنا بخلي الـ
+
+270
+00:27:25,980 --> 00:27:31,040
+الـ الـ الـ الـ DNA والكروموزومات تصبح بشكل مضغوط،
+
+271
+00:27:31,040 --> 00:27:37,530
+وبعد ذلك كنا نوقف، حتى تظبط هذا الأمر نوقفها على طاولة
+
+272
+00:27:37,530 --> 00:27:43,950
+على إيش؟ يعني بارتفاع طويل، ونلقي الخلية
+
+273
+00:27:43,950 --> 00:27:50,750
+أو الشريحة اللي فيه الخلايا، وفي لحظة معينة بتجدوا
+
+274
+00:27:50,750 --> 00:27:56,050
+صورة مثل هذه الصورة. فهذا فحص يسمى Karyotype، يتم
+
+275
+00:27:56,050 --> 00:27:59,670
+صبغ الـDNA بالجِيزة
+
+276
+00:28:02,810 --> 00:28:06,790
+Stain اللي هو بيسموه الـ G-banding بهذا الشكل،
+
+277
+00:28:06,790 --> 00:28:12,390
+وبنتج عندي صورة بهذا الشكل، بقدر من خلالها أدرس
+
+278
+00:28:12,390 --> 00:28:19,450
+خواص وأدرس الـ chromosomes والـ DNA كله بشكل كامل،
+
+279
+00:28:19,450 --> 00:28:25,450
+يعني كمجموعة كاملة موجودة في الخلية. فهذه عبارة عن
+
+280
+00:28:25,450 --> 00:28:30,820
+أن أنا وقفت انقسام الخلية عند مرحلة الـ Metaphase،
+
+281
+00:28:30,820 --> 00:28:37,700
+وبيكون الـ DNA بأكبر شكل مضغوط فيه، وبستخدم صبغة،
+
+282
+00:28:37,700 --> 00:28:41,840
+وبحاول أزيدها بحيث تتناثر الـ Chromosomes شوية،
+
+283
+00:28:41,840 --> 00:28:47,040
+بعيد عن بعض، عايز أشوفها. ولما أشوف الصورة هذه اللي
+
+284
+00:28:47,040 --> 00:28:52,320
+هي هذه، بتكون مطبوعة على ورقة، بجيب مقص وبقص الـ
+
+285
+00:28:52,320 --> 00:28:58,980
+Chromosomes وبرتبها بهذا الشكل. فأحيانًا، يعني كل
+
+286
+00:28:58,980 --> 00:29:02,900
+اثنين من الكروموزومات لازم يكونوا متشابهات، وبدها
+
+287
+00:29:02,900 --> 00:29:10,660
+تخيل إن الشيء محطوط بشكل مظبوط. فالـ كروموزومات
+
+288
+00:29:10,660 --> 00:29:17,600
+واحد الـ Pairs اللي هم الـ22 وهنا ذكر الـXY
+
+289
+00:29:17,600 --> 00:29:24,800
+كروموزومات، وبكون شكلهم بهذا الشكل. هذه تجربة أنا
+
+290
+00:29:24,800 --> 00:29:30,000
+كطالب طب، كنا في الكويت سويتها وعملتها بيدي، إني
+
+291
+00:29:30,000 --> 00:29:36,700
+أشوف. وهذا يعني إذا بدكم إياها، تفق مع مختبر اللي هو
+
+292
+00:29:36,700 --> 00:29:40,560
+بيسوي عملية فحص الجينات عن طريق، بيقولوله فحص الـ
+
+293
+00:29:40,560 --> 00:29:45,840
+Karyotype. هنا لا نستطيع يعني التكلم عن
+
+294
+00:29:45,840 --> 00:29:50,590
+الـIndividual Genes. إحنا هنا نقدر مثلًا زي ما
+
+295
+00:29:50,590 --> 00:29:54,750
+تعرفوا تسمعوا «Down Syndrome»، «Trisomy 21»، إنه
+
+296
+00:29:54,750 --> 00:29:59,010
+بيكون بدل ما عندي مثلًا كروموزوم 21، بدل ما هم
+
+297
+00:29:59,010 --> 00:30:07,470
+اثنين، pair، بيكون عندي ثلاثة، أو XXY مثلًا، أو
+
+298
+00:30:07,470 --> 00:30:10,670
+«Trisomy»، يعني راح نحكي على الكروموزوم
+
+299
+00:30:10,670 --> 00:30:14,090
+الـ Anomalies، وهذول بيكونوا من خلال هذا الفحص اللي
+
+300
+00:30:14,090 --> 00:30:20,290
+بتسميه «Karyotype». فهذا أحد الفيقوسات، وهذه هنا بهذا
+
+301
+00:30:20,290 --> 00:30:27,090
+الشكل هي Metaphase في الـ Mitosis، بتكون يعني في
+
+302
+00:30:27,090 --> 00:30:31,750
+لحظة ما بتكون الـ DNA Condensed، وهذه بتكون، شو
+
+303
+00:30:31,750 --> 00:30:37,470
+اسمها؟ بتكون يعني لدراسة الكروموزومات الموجودة والـ
+
+304
+00:30:37,470 --> 00:30:42,750
+G-banding، يعني هو اللي نستفيد منه حتى أحيانًا في
+
+305
+00:30:42,750 --> 00:30:50,330
+تشخيص بعض الحالات، أو وين الواحد يبحث أو شو الأشياء
+
+306
+00:30:50,330 --> 00:30:54,670
+اللي بتكون موجودة. يعني دائمًا إحنا لما نرسم الـDNA
+
+307
+00:30:54,670 --> 00:31:00,750
+أو الـ Chromosome بنرسمه بهذا الشكل، وعليه نطاقات،
+
+308
+00:31:00,750 --> 00:31:04,990
+عليه شيء أغمق، أفتح، كده، هذه بتساعد في عملية
+
+309
+00:31:04,990 --> 00:31:09,770
+الوصف وعملية التعامل
+
+310
+00:31:09,770 --> 00:31:14,490
+مع الـ Chromosome، في سؤال؟ في سؤال، يا دكتور،
+
+311
+00:31:14,490 --> 00:31:18,210
+بخصوص المادة، يعني الدكتورة اسمها بتسأل، المادة
+
+312
+00:31:18,210 --> 00:31:20,830
+اللي بتوقف عملية الـ metaphase أو المقصر،
+
+313
+00:31:20,830 --> 00:31:24,210
+الـ Colchicine، آه الـ Colchicine، حكيتها، مخرب
+
+314
+00:31:24,210 --> 00:31:28,250
+الـ Spindle fiber أو الـ Microtubules، هذول، هذا
+
+315
+00:31:28,250 --> 00:31:31,730
+الـ mechanism of action، يعتبر الـ main mechanism of
+
+316
+00:31:31,730 --> 00:31:35,510
+action، وده يستخدم بشكل كبير، طبعًا الجرعات بتكون
+
+317
+00:31:35,510 --> 00:31:42,780
+مختلفة، وبتحطوه على الـ، شو بيسموها، يعني الـ الـ Cell
+
+318
+00:31:42,780 --> 00:31:48,260
+Culture، يعني في الـ Environment تبع الخلية، فأه،
+
+319
+00:31:48,260 --> 00:31:53,180
+ماشي، يعني هذه تجربة بتسمى عملية الـ Karyotype،
+
+320
+00:31:53,180 --> 00:31:59,020
+وهيك بتكون نتيجتها، بتكون إنها تظهر الكروموزومات
+
+321
+00:31:59,020 --> 00:32:04,960
+بشكل مضغوط، ويتم صبغها بحيث تظهر فيها النطاقات أو
+
+322
+00:32:04,960 --> 00:32:09,860
+الـ Banding هذا، وهيستفاد منها في عملية دراسة
+
+323
+00:32:10,230 --> 00:32:15,130
+بالذات الأمراض الكروموزومية أو ما يُعرف بالكروموزوم
+
+324
+00:32:15,130 --> 00:32:20,650
+بس مش لجين واحد، لأنه بالمتوسط كل كروموزوم فيه
+
+325
+00:32:20,650 --> 00:32:25,650
+حوالي ألف جين، يعني عدد كبير من الجينات، فبالتالي
+
+326
+00:32:25,650 --> 00:32:30,730
+يعني ما بتفيد لدراسة شيء دقيق، إنما هيك بيكون لظاهرة
+
+327
+00:32:30,730 --> 00:32:34,970
+كبيرة كتير زي الـ Chromosomal Anomalies. فاحنا رح نحكي
+
+328
+00:32:34,970 --> 00:32:35,830
+عنهم بعد شوية.
+
+329
+00:32:38,690 --> 00:32:43,950
+فالـ … الـ إحنا يعني اللي بدنا نـ … يعني من
+
+330
+00:32:43,950 --> 00:32:51,130
+الظواهر اللي نتكلم عنها، إنه في حالة، في مرحلة معينة الـ
+
+331
+00:32:51,130 --> 00:32:58,790
+Interphase اللي بيكون فيه داخل الخلية، بيكون هناك
+
+332
+00:32:58,790 --> 00:33:05,670
+جدار نواة، وهناك يكون الـ DNA على شكل خيط رفيع،
+
+333
+00:33:06,370 --> 00:33:11,770
+فبالتالي خيط يعني، حتى يتم نسخه، لتكوين
+
+334
+00:33:11,770 --> 00:33:18,630
+الـ Chromosomes، فيه آسف، ونسخه، وعمل الـ RNA وتكوين
+
+335
+00:33:18,630 --> 00:33:23,130
+البروتينات منه، بيكون ما يسمى Decondensed، يعني
+
+336
+00:33:23,130 --> 00:33:30,750
+بيكون مش مضغوط. فلما نبدأ في عملية الـ Mitosis لازم
+
+337
+00:33:30,750 --> 00:33:37,770
+هذا الـ DNA يتم لفه وربطه بشكل مضغوط جدًا جدًا في
+
+338
+00:33:37,770 --> 00:33:42,250
+الـ Prophase، ويهيئه لعملية الـ Metaphase، لما نوقفه
+
+339
+00:33:42,250 --> 00:33:47,670
+بالنص، ويتم فصله. فدايمًا في كل عملية انقسام خلية،
+
+340
+00:33:48,660 --> 00:33:54,100
+الخيط الـ DNA اللي هو كان أصلًا خيط طويل جدًا،
+
+341
+00:33:54,100 --> 00:34:02,040
+بتم لفه وربطه، يعني زي ضمة أحبال ملفوفة بشكل شديد،
+
+342
+00:34:02,040 --> 00:34:07,080
+بحيث تقريبًا تصبح جسم صلب أو جسم منفصل، بحيث يتم
+
+343
+00:34:07,080 --> 00:34:12,640
+فصله لنسختين، وبعدين يتم فكه مرة ثانية. الـ Prophase
+
+344
+00:34:12,640 --> 00:34:17,040
+والـ Metaphase بيكون فيه غشاء نواة، بنشيله، وبعدين
+
+345
+00:34:17,040 --> 00:34:22,080
+برجع مرة ثانية. فهذه كلها ظواهر بتكون موجودة، ولازم
+
+346
+00:34:22,080 --> 00:34:28,800
+واحد ينتبه لها. الـ Chromosome replication في
+
+347
+00:34:28,800 --> 00:34:34,860
+حالة اللي حكينا 4N، كيف بيكون؟ إذا افترضنا إنه
+
+348
+00:34:34,860 --> 00:34:42,380
+الـ … أنا بالأول كان عندي كروموزوم بهذا الشكل الـ …
+
+349
+00:34:42,380 --> 00:34:50,510
+الـ … الـ N، هنا بدنا نتكلم، يعني ندخل على قضية
+
+350
+00:34:50,510 --> 00:34:55,110
+الانقسام المنصف اللي هو الـ Meiosis، اللي هو بتتم
+
+351
+00:34:55,110 --> 00:35:04,510
+فيه بتكوين اللي هما الـ Sperm والـ Egg.
+
+352
+00:35:05,150 --> 00:35:10,570
+أيوا يا رُباط، احكي، في سؤال يا دكتور، يعني قبل ما
+
+353
+00:35:10,570 --> 00:35:13,430
+تسأل دكتور رُباط، في سؤال من دكتورة جمانة تقول
+
+354
+00:35:13,430 --> 00:35:19,470
+عملية النسخ بتصير في الـ Interphase، بس؟ لأ، بالـ S،
+
+355
+00:35:19,470 --> 00:35:27,630
+النسخ هي، اللي هي هنا يعني، حتى لما نيجي بهذه
+
+356
+00:35:27,630 --> 00:35:35,450
+الظاهرة، ماشي، النسخ بتتم في هذه اللحظة، اللي هي
+
+357
+00:35:35,450 --> 00:35:40,110
+بتكون الخلية بدأت في الـ G1، بتكون شغالة على راحتها،
+
+358
+00:35:40,110 --> 00:35:45,830
+بتقرر أو بتجيها أمر أو دافع إنها بدأت تنقسم، أو
+
+359
+00:35:45,830 --> 00:35:51,270
+بحاجة تنقسم. أول شيء بتعمله، بتضاعف كمية الـ DNA
+
+360
+00:35:51,270 --> 00:35:56,570
+تبعتها، بترتاح شوية بالـ G2 phase، وبعدين تبدأ تدخل
+
+361
+00:35:56,570 --> 00:36:01,350
+في الـ mitosis اللي هي عملية الإنقسام. فالانقسام من
+
+362
+00:36:01,350 --> 00:36:07,980
+2N لـ 4N بتتم في الـ S-Phase. وهنا أعطيكم، إذا افترضنا
+
+363
+00:36:07,980 --> 00:36:14,700
+الخلية انقسمت خلال 24 ساعة، مرة بتكون في الـ G1 مثلًا
+
+364
+00:36:14,700 --> 00:36:19,360
+نص النهار، وبعدين بدها 6 ساعات، أو آسف يعني، إنت
+
+365
+00:36:19,360 --> 00:36:26,280
+قريبًا 12 ساعة ثانية عشان تنقسم، بالأول بتضاعف
+
+366
+00:36:26,280 --> 00:36:31,280
+الـ DNA اللي هي الـ S-Phase، وبعدين بترتاح شوية
+
+367
+00:36:31,280 --> 00:36:36,340
+بالـ G2، يعني بتجهز، عشان تبدأ الـ Mitosis،
+
+368
+00:36:36,340 --> 00:36:40,560
+وبعدين بتصير الـ Mitosis. الـ Mitosis هذا، اللي هو
+
+369
+00:36:40,560 --> 00:36:46,640
+إنه بتكون Centrosomes، وبصير الـ DNA والـ
+
+370
+00:36:46,640 --> 00:36:51,680
+Chromosomes هيك تتبين وتـ Condense، وبعدين الـ
+
+371
+00:36:51,680 --> 00:36:56,200
+Prometaphase بتبدأ يكون Spindle Fiber وبختفي الـ
+
+372
+00:36:56,200 --> 00:37:01,100
+Nuclear Membrane، وبعدين بالـ Metaphase بتصف بهذا
+
+373
+00:37:01,100 --> 00:37:06,270
+الشكل، وبعدين بيتم جر الـ DNA للطرفين، وبعدين تنقسم
+
+374
+00:37:06,270 --> 00:37:11,350
+الخلية، بتنتصف. فده برجع تكوين الـ Nuclear Membrane،
+
+375
+00:37:11,350 --> 00:37:19,090
+وبيفك الـ DNA وبيصير Uncondensed، واضح؟ رُباط؟ بدها
+
+376
+00:37:19,090 --> 00:37:24,470
+أي شيء؟ يبدو أنه ما عندها سؤال، أو لم تُجب عن السؤال.
+
+377
+00:37:24,470 --> 00:37:31,430
+بالنسبة للظاهرة الأخرى اللي هي عملية الـ Meiosis،
+
+378
+00:37:31,430 --> 00:37:36,930
+اللي هو الانقسام المنصف، اللي هو إنه بنتج فيه الجاميتات
+
+379
+00:37:36,930 --> 00:37:44,390
+اللي هما الـ Sperm والـ Egg، تبدأ
+
+380
+00:37:44,390 --> 00:37:50,930
+أيضًا يعني بتكون الـ Resting Cell، أو الخلية
+
+381
+00:37:50,930 --> 00:37:57,750
+الأصلية بتكون عندنا كمية DNA معينة، ماشي. نبدأ إنه
+
+382
+00:37:57,750 --> 00:38:04,680
+أول شيء الـ DNA بتضعف، وبعدين بتنقسم على مرحلتين،
+
+383
+00:38:04,680 --> 00:38:11,980
+المرحلة الأولى بتصير كروموزوم واحد في كل جهة، وبعدين
+
+384
+00:38:11,980 --> 00:38:17,640
+بنقسم نص الكروموزوم، اللي هي الـ Haploid Gametes،
+
+385
+00:38:17,640 --> 00:38:25,180
+يعني بالأخير بكون 2N، بوصل 4N، بعطينا أربعة 1N
+
+386
+00:38:25,180 --> 00:38:32,280
+Gametes، أو اللي هي Sperm أو Fertilized. فهذه خطوات
+
+387
+00:38:32,280 --> 00:38:38,100
+
+445
+00:43:58,510 --> 00:44:04,610
+تبدأ التورة بتصير أن Secondary Oocyte و Myotic
+
+446
+00:44:04,610 --> 00:44:10,590
+Spindle و First Polar Body بتاخد عنهم بعدين بحيث
+
+447
+00:44:10,590 --> 00:44:17,110
+أنه بتكون عندي الـ يعني هنا الـ Meiosis I اللي أنا
+
+448
+00:44:17,110 --> 00:44:22,110
+بتذكرها بحيث هنا الـ Meiosis II بحيث أنه ينتج عندي
+
+449
+00:44:22,110 --> 00:44:29,030
+بيضة واحدة بالنسبة لإذا مقارنتها بالذكر يعني هنا
+
+450
+00:44:29,030 --> 00:44:37,120
+كان 2N مرحلة صار 4N وبالـ Meiosis 1 انتهى لـ 2N
+
+451
+00:44:37,120 --> 00:44:44,720
+وMeiosis 2 صار 1N ان نتخيل انه في الأنثى الـ
+
+452
+00:44:44,720 --> 00:44:52,780
+Female بعد ما أصبح عندي 4N هذا الجزء تحول إلى ما
+
+453
+00:44:52,780 --> 00:44:58,570
+يسمونه Polar Body يعني خلية ميتة لأنه يعني في
+
+454
+00:44:58,570 --> 00:45:03,710
+الأنثى المطلوب بويضة واحدة فقط فما في داعي نكون
+
+455
+00:45:03,710 --> 00:45:09,530
+بويضات كثير فالـ الـ الـ الـ لما تمشي بالطريق راح
+
+456
+00:45:09,530 --> 00:45:13,590
+تمشي كأنه بطريق في هذا الشكل واحد فبما أنه
+
+457
+00:45:13,590 --> 00:45:17,950
+انقسامين، الانقسام الأول بيعطينا اسمه الـ First
+
+458
+00:45:17,950 --> 00:45:22,210
+Polar Body فهذا طبعا ما بتكونه، وبعدين لما تنقسم
+
+459
+00:45:22,210 --> 00:45:25,690
+من Two End لـ One End برضه بتعطينا Polar Body ثاني
+
+460
+00:45:26,090 --> 00:45:31,870
+فزي ما هم شايفين هنا، بيحطوا إنه الـ Fertilized Egg
+
+461
+00:45:31,870 --> 00:45:36,810
+أو قبل الـ Fertilization، بدي يكون الـ First Polar
+
+462
+00:45:36,810 --> 00:45:41,130
+Body وبعدين الـ Second Polar Body اللي هم يعني،
+
+463
+00:45:41,130 --> 00:45:46,370
+لأن الأنثى، احنا بحاجة عادة في كل دورة لخلية واحدة
+
+464
+00:45:46,370 --> 00:45:51,450
+بس فقط، بيضة واحدة، فهذه كلها دواهر بتصير وبعدين
+
+465
+00:45:51,450 --> 00:45:55,630
+بيصير عملية الـ Fertilization وبترجع بتكون الإنسان
+
+466
+00:45:55,630 --> 00:46:02,610
+من 2N و Fertilized egg فهذه باقية الـ أو الظواهر
+
+467
+00:46:02,610 --> 00:46:09,170
+اللي بتصير في اللي بنسميه الـ Meiosis الـ Meiosis
+
+468
+00:46:09,170 --> 00:46:13,490
+اللي هو الإنقسام المنصف اللي بنتجه إنه الـ Eggs
+
+469
+00:46:13,490 --> 00:46:19,810
+والـ Sperms وبكون النتيجة إنه راح يكون عندنا 1N of
+
+470
+00:46:19,810 --> 00:46:26,700
+DNA بيكون موجود في الخلية هذه؟ في أسئلة؟ فيها دكتور
+
+471
+00:46:26,700 --> 00:46:30,540
+سؤال من دكتور معتز بخصوص عملية الـ Recombination
+
+472
+00:46:30,540 --> 00:46:37,240
+نعم بيسأل هل لها تأثير؟ طبعاً لها تأثير كبير، يعني
+
+473
+00:46:37,240 --> 00:46:43,580
+في ظواهر كثيرة راح نحكي شوفوا، الأهمية اللي بنحكي
+
+474
+00:46:43,580 --> 00:46:51,270
+اللي هو حتى يفسر الواحد الأمراض والحالات وكيف
+
+475
+00:46:51,270 --> 00:46:56,770
+الإنسان بتكون وأسباب ليش تمشي الأمور بهذا الشكل
+
+476
+00:46:56,770 --> 00:46:59,950
+يعني
+
+477
+00:46:59,950 --> 00:47:06,230
+إذا تخيلنا قضية إنه لو افترضنا إنه كل البشر
+
+478
+00:47:06,230 --> 00:47:12,490
+متشابهين تمامًا ماشي كان لو أتى أي مرض أو أي حالة
+
+479
+00:47:12,490 --> 00:47:21,110
+أو أي عدو بتلاقينا كلنا راح نتأثر بشكل شديد ولكن
+
+480
+00:47:21,110 --> 00:47:26,170
+يعني وقاية للبشرية
+
+481
+00:47:26,170 --> 00:47:29,690
+كلها ربنا حاط فينا إنه فيه اختلافات بيننا
+
+482
+00:47:29,690 --> 00:47:37,650
+والاختلافات بيظلها متكررة وما فيش تقريبًا لإثنين
+
+483
+00:47:37,650 --> 00:47:44,390
+بشر متشابهين تمامًا حتى لو يعني أقارب يعني راح
+
+484
+00:47:44,390 --> 00:47:49,000
+نحكي عن ظواهر بالمعنى كروموزوم مش كروموزوم ثاني،
+
+485
+00:47:49,000 --> 00:47:53,600
+يعني تستنى على هذه المواضيع، أه، إلها أهمية كبيرة،
+
+486
+00:47:53,600 --> 00:47:59,680
+Recombination، وبتتدخل يعني في جوانب كثيرة، نعم،
+
+487
+00:47:59,680 --> 00:48:03,520
+في أسئلة أخرى؟ في سؤال من الدكتور، الدكتور
+
+488
+00:48:03,520 --> 00:48:09,060
+أويجدان، بخصوص الـ Polar Body، أيش المقصود فيها؟
+
+489
+00:48:09,060 --> 00:48:16,110
+لما تسير عملية الإنقسام المنصف، ماشي، الانقسام
+
+490
+00:48:16,110 --> 00:48:24,870
+المنصف الذكر أنا بدي الأربع Sperms الـ Sperms
+
+491
+00:48:24,870 --> 00:48:32,090
+يعني الذكر بيكون عنده ملايين الحيوانات المنوية
+
+492
+00:48:32,090 --> 00:48:36,110
+وتتسابق اللي يخفي يكون أفضل واحد فيها اللي يصل
+
+493
+00:48:36,110 --> 00:48:42,310
+اللي يلقح البويضة عند الأنثى المطلوب أن تكون بويضة
+
+494
+00:48:42,310 --> 00:48:50,530
+واحدة فقط، فإذا تخيلتي يعني كانت الخلية بدأت بالـ
+
+495
+00:48:50,530 --> 00:48:57,610
+Meiosis I وبتكون قبلها وصلت زي ما ذكرنا من قبل إنه
+
+496
+00:48:57,610 --> 00:49:05,090
+أعطت سوّت S phase وعملت 4N فلما تنقسم الإنقسام
+
+497
+00:49:05,090 --> 00:49:10,270
+الأول واحدة من البيتين اللي أحسن أو اللي راح تكون
+
+498
+00:49:10,270 --> 00:49:16,710
+بيضة أحسن هي اللي بتكمل والثانية يتم يعني تجميدها
+
+499
+00:49:16,710 --> 00:49:24,850
+ويتم يعني ديش أقول قضاء عليها بيظل إنه في داخل
+
+500
+00:49:24,850 --> 00:49:32,930
+تركيب الـ Polar Body في المبيض الأنثى بنلاقي هيك نواة
+
+501
+00:49:32,930 --> 00:49:40,800
+يعني مضغوطة بشكل بيسموه Polar Body بكون هو الخلية
+
+502
+00:49:40,800 --> 00:49:46,100
+الثانية اللي يتم التخلص منها بهذا الطريق فمع
+
+503
+00:49:46,100 --> 00:49:49,860
+الإنقسام الأول، بتتم تكوين الـ First Polar Body
+
+504
+00:49:49,860 --> 00:49:54,320
+كمية الـ DNA اللي فيه بدي تكون 2N زي اللي جنبها
+
+505
+00:49:54,320 --> 00:50:01,900
+التانية لما تنقسم بالـ Meiosis 2 وتعطينا 1N DNA برضه
+
+506
+00:50:01,900 --> 00:50:08,340
+بتكون Polar Body ثاني، بيكون فيه 1N DNA وبكون اثنين
+
+507
+00:50:08,340 --> 00:50:12,200
+موجودات، لأنه أنا عندي انقسامين وفي حالة البويضة
+
+508
+00:50:12,200 --> 00:50:16,940
+أنا ما بدي غير بويضة واحدة، بس، ماشي، فعشان هيك
+
+509
+00:50:16,940 --> 00:50:25,200
+طريقتها مختلفة وهذا الـ Polar Body هو تمثيل أو بقية
+
+510
+00:50:25,200 --> 00:50:33,260
+الخلية اللي كانت في الانقسام اللي لم تكمل الطريق
+
+511
+00:50:33,260 --> 00:50:37,070
+ولم يكتب لها إنها تكمل الطريق، بحيث إنه بكون عندي
+
+512
+00:50:37,070 --> 00:50:41,050
+بويضة واحدة يعني هي عشان ننتج بويضة واحدة من
+
+513
+00:50:41,050 --> 00:50:48,230
+الخلية الأصلية اللي هي كانت صارت 4N بعد ما كانت 2N
+
+514
+00:50:48,230 --> 00:50:54,730
+اللي هي بداية ما يوصف، واضح؟
+
+515
+00:50:54,730 --> 00:51:06,150
+فيه أسئلة؟ هيك احنا بنكون خلصنا دواهر الفصل الثاني
+
+516
+00:51:06,340 --> 00:51:12,700
+أه، في حد عنده سؤال؟ لحد الآن تمام يا دكتور أيه؟
+
+517
+00:51:12,700 --> 00:51:18,720
+نبدأ الآن بمحاضرة اليوم في سؤال من أحمد يعني يعني
+
+518
+00:51:18,720 --> 00:51:23,000
+هو سؤال ربما يعني لسه بدري عليه كيف بتصير التوائم
+
+519
+00:51:23,000 --> 00:51:29,040
+الغير متطابقة؟ أه، شوف التوائم الغير متطابقة
+
+520
+00:51:29,040 --> 00:51:38,830
+أحيانًا بتنتج Boy-The-Tail يعني ويدتين بتكونوا و
+
+521
+00:51:38,830 --> 00:51:49,150
+أحيانًا يعني بتتم عملية تخصيبهم بحيوانين منويين
+
+522
+00:51:49,150 --> 00:51:55,070
+اثنين أحيانًا يعني الطواقم المتطابقة إنه بعد ما
+
+523
+00:51:55,070 --> 00:52:01,750
+خلية واحدة تكون ملقحة تنقسم إلى خليتين يُعاملوا
+
+524
+00:52:01,750 --> 00:52:06,580
+على إنهم بيطلب من الجسم واحد وبنقسمه لجسمين
+
+525
+00:52:06,580 --> 00:52:14,540
+وبالتالي بيصبحوا خليتين فيه دراسات حدثت بالتاريخ
+
+526
+00:52:14,540 --> 00:52:20,680
+وموجودة يعني إنه امرأة بتطلع ببويضتين ويتم تلقيحهم
+
+527
+00:52:20,680 --> 00:52:24,880
+بحيوانات منوية من شخصين مختلفين، تخيل يعني شو صار
+
+528
+00:52:24,880 --> 00:52:29,820
+بالحالة هذه يعني، بس هي شيء موجود في دراسة
+
+529
+00:52:29,820 --> 00:52:35,340
+الكروموزومات البشر والأشياء العجيبة غريبة يعني فهي
+
+530
+00:52:35,340 --> 00:52:41,160
+كلها ظواهر ممكنة وإن شاء الله سنتكلم بشكل أدق كيف
+
+531
+00:52:41,160 --> 00:52:46,030
+يتم دراسة في هذا الموضوع الآن دائمًا حتى يفهم
+
+532
+00:52:46,030 --> 00:52:51,170
+الواحد شو اللي بيصير بدي أكون عنده آليات للدراسة
+
+533
+00:52:51,170 --> 00:52:56,290
+ميكروسكوبات معينة حتى أشوف شو اللي بيصير فعلى
+
+534
+00:52:56,290 --> 00:53:02,630
+استخدام الأجهزة والـ والفهم كيف يدرس هذا الموضوع
+
+535
+00:53:02,630 --> 00:53:07,710
+ممكن الواحد يعني يفهمها بشكل أفضل يعني فهي كما
+
+536
+00:53:07,710 --> 00:53:11,450
+ذكرت يعني راح ناخدها بشكل أدق يعني، ماشي؟
+
+537
+00:53:14,610 --> 00:53:20,110
+المحاضرة اليوم راح نبدأ بالـ Human Genome والجين
+
+538
+00:53:20,110 --> 00:53:27,730
+Structure and Function يعني نفهم كيف الـ DNA
+
+539
+00:53:27,730 --> 00:53:31,970
+المادة هذه اللي موجودة في النواة اللي موجودة في كل
+
+540
+00:53:31,970 --> 00:53:39,910
+الخلايا زي بعض اللي هي فيها الشيفرة الوراثية اللي
+
+541
+00:53:39,910 --> 00:53:46,130
+فيها المحدد لكيف مظهر الإنسان راح يكون بيعطينا
+
+542
+00:53:46,130 --> 00:53:51,990
+المظهر اللي احنا بنشوفه بالآخر فاحنا
+
+543
+00:53:51,990 --> 00:54:04,270
+عندما نتكلم عن الإنسان كـ يعني كمخلوق أو ككائن حي
+
+544
+00:54:04,270 --> 00:54:14,250
+أو organism، ماشي لما نيجي ندرسه ندرس طريقة تركيبه
+
+545
+00:54:14,250 --> 00:54:19,870
+من خلال الفهم التشريح وظائف الأعضاء والسلوكيات
+
+546
+00:54:19,870 --> 00:54:27,010
+و يعني الكيميائيات تبعته والأشياء هذه لما ندرس حتى
+
+547
+00:54:27,010 --> 00:54:31,330
+تركيب هذه الترتيب
+
+548
+00:54:31,330 --> 00:54:37,630
+هذه المظاهر الكبيرة نجد أنها بالأخير يعني وحدة
+
+549
+00:54:37,630 --> 00:54:44,280
+بناء الإنسان هي من الخلايا تفاعل الخلايا وتأثر
+
+550
+00:54:44,280 --> 00:54:48,940
+الخلايا ووظيفة الخلايا وتفاعل الخلايا مع بعض هو ما
+
+551
+00:54:48,940 --> 00:54:54,980
+يعطينا المظهر الخارجي بالنهاية ففي
+
+552
+00:54:54,980 --> 00:55:00,740
+كل جوانب وظائف الخلايا تجد أنها تعتمد على
+
+553
+00:55:00,740 --> 00:55:05,380
+البروتينات في الـ Jacket الرئيسي أو المركبات
+
+554
+00:55:05,380 --> 00:55:11,310
+الموجودة فيها فالـ Idea تبعت هذه الخلية التشارك
+
+555
+00:55:11,310 --> 00:55:17,550
+الخلايا مع بعض بالتحكم ببعض والإشارة لبعض عن بعض
+
+556
+00:55:17,550 --> 00:55:22,130
+لعمل أشياء معينة تحرك الخلايا، انقسام الخلايا
+
+557
+00:55:22,130 --> 00:55:31,310
+التصاق الخلايا ببعض حتى تكون عضو الإنفعال عند حدوث
+
+558
+00:55:31,310 --> 00:55:41,100
+مهيج خارجي وشيء خارجي كلها تعتمد على يعني تفاعل
+
+559
+00:55:41,100 --> 00:55:49,240
+البروتينات مع بعض مع الواقع مع غيرها فالبروتينات
+
+560
+00:55:49,240 --> 00:55:52,360
+هذه اللي احنا بنشوفها ورسميها بهذا الشكل على هذا
+
+561
+00:55:52,360 --> 00:55:59,880
+المستوى تكون نتيجة إنه من الجينوم اللي هو مجمل
+
+562
+00:55:59,880 --> 00:56:07,160
+المادة الوراثية الـ DNA كله يكون هناك قطع تسمى
+
+563
+00:56:07,160 --> 00:56:14,620
+جينات ماشي، كل جين بتتم عملية راح نحكي عملية الـ
+
+564
+00:56:14,620 --> 00:56:20,560
+Transcription ليعطينا الـ RNA اللي هو الـ
+
+565
+00:56:20,560 --> 00:56:25,900
+Messenger RNA طبعاً بالأول بيكون Primary RNA ممكن
+
+566
+00:56:25,900 --> 00:56:32,960
+ما يكونش الـ Messenger أول ما يطلع وبتكون يعني RNA
+
+567
+00:56:32,960 --> 00:56:37,540
+يمكن هنا الـ Nascent أو Early أو الـ Primary RNA
+
+568
+00:56:37,540 --> 00:56:40,980
+بنسميه مثلاً أحياناً فـ  يعطينا بعدين
+
+569
+00:56:40,980 --> 00:56:45,260
+بالـ Translation عملية إنه يعطينا البروتين البروتين
+
+570
+00:56:45,260 --> 00:56:50,600
+هذا هو اللي بيقدي الوظيفة من خلال الـ Cell
+
+571
+00:56:50,600 --> 00:56:56,460
+Function اللي بيعطينا تكوين الـ Organs اللي بيعطينا
+
+572
+00:56:56,460 --> 00:57:02,320
+بعدين كل الـ Organism في يعني
+
+573
+00:57:02,320 --> 00:57:10,450
+الأخير كثير من الخواص والظواهر والـ فصيلة الدم
+
+574
+00:57:10,450 --> 00:57:15,530
+ولون الشعر وقوة العضلات ووظيفة الإنسولين ووظيفة
+
+575
+00:57:15,530 --> 00:57:21,070
+المناعة ووظيفة كذا وذكاء هذا الإنسان وقدراته
+
+576
+00:57:21,070 --> 00:57:26,870
+العقلية وردود فعله كيف وكذا كلها بالأخير ترجع إلى
+
+577
+00:57:26,870 --> 00:57:33,330
+التفاعل الدرجة الأساسية للـ Genome مع ممكن الـ
+
+578
+00:57:33,330 --> 00:57:37,770
+Environment في جانب ثاني بحيث إنه بيعطينا الـ Gene
+
+579
+00:57:37,770 --> 00:57:41,270
+Products اللي هم البروتينات اللي أنا بشوفها اللي
+
+580
+00:57:41,270 --> 00:57:45,470
+بالأخير بتعطيني خواص هذا الإنسان وميزته طبعاً
+
+581
+00:57:45,470 --> 00:57:52,130
+الإنسان يعني إلا يكون البيئة الها دور في قضية
+
+582
+00:57:52,130 --> 00:57:58,250
+مظهريته وقدراته السابقة وما تعرض له من إشعاع
+
+583
+00:57:58,250 --> 00:58:04,570
+وكيميائيات وغذاء واحتياجات وميكروبات وغيرها كلها
+
+584
+00:58:04,570 --> 00:58:12,510
+بتعطينا خاصية الواحد منها فهي أهمية فهم الجينوم
+
+585
+00:58:12,510 --> 00:58:24,050
+وفهم الجينات اللي فيه لما ندرس هذا الموضوع
+
+586
+00:58:25,370 --> 00:58:31,270
+فهنا مثلًا مثال، أنا كان صراحة عندي هيك بوستر كبير
+
+587
+00:58:31,270 --> 00:58:38,110
+حوالي يعني متر ونصف متر، يعني شيء كبير حاطين
+
+588
+00:58:38,110 --> 00:58:44,850
+الـ 44، الـ 46 كروموزوم أو الـ 23 كروموزوم على
+
+589
+00:58:44,850 --> 00:58:52,430
+أساس المعدل الـ X والـ Y وحاطين كل واحد القطع تبعينه
+
+590
+00:58:53,340 --> 00:59:01,660
+الـ الـ الـ Chromosome لما نشوفه الـ P القطعة
+
+591
+00:59:01,660 --> 00:59:07,680
+الصغيرة الـ Q القطعة الطويلة هذه فبنسميها وبعدين
+
+592
+00:59:07,680 --> 00:59:13,820
+أنا ممكن أدرس يعني فيه من خلال تقنية الـ PCR
+
+593
+00:59:13,820 --> 00:59:16,220
+Polymerase Chain Reaction اللي هي عملية
+
+594
+00:59:16,220 --> 00:59:21,570
+الـ Sequencing اللي هي أنه أنا أدرس الـ الـ DNA
+
+595
+00:59:21,570 --> 00:59:26,250
+وأنا كنت ذكرت معلومة بالذات للـ DNA تبع البشر إنه
+
+596
+00:59:26,250 --> 00:59:32,610
+حوالي 95% منه لا قيمة له عبارة عن repeats وواضح
+
+597
+00:59:32,610 --> 00:59:37,050
+لما تيجي تقرأ كأنه يعني إذا اعتبرت أحرف
+
+598
+00:59:39,650 --> 00:59:45,370
+مثلًا، يعني نفترض إنه هذا الـ Gene هو قصيدة معينة
+
+599
+00:59:45,370 --> 00:59:53,870
+مثلًا، ولد الـ  يعني في مدح الرسول ﷺ أو طلع البدر
+
+600
+00:59:53,870 --> 00:59:59,010
+علينا، نفترض هيك، فبتلاقي قطعة كبيرة مثلًا، نفترض
+
+601
+00:59:59,010 --> 01:00:03,850
+بالأحرف مثلًا، ألف، ألف، ألف، ألف، ألف، ألف، ألف،
+
+602
+01:00:03,850 --> 01:00:07,010
+ألف، ألف، ألف، ألف، ألف، ألف، ألف، ألف، ألف، ألف،
+
+603
+01:00:19,540 --> 01:00:20,940
+عالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعال
+
+604
+01:00:26,570 --> 01:00:31,170
+حكينا الـ Centromere اللي هو حكيناه هنا اللي
+
+605
+01:00:31,170 --> 01:00:38,010
+استفاد منه في عملية فصل الـ Myosis والـ Metaphase
+
+606
+01:00:38,010 --> 01:00:41,290
+وهذه
+
+607
+01:00:41,290 --> 01:00:45,130
+بتكون عملية الـ Bands لما أنا أجي أدرس الـ Band
+
+608
+01:00:45,130 --> 01:00:52,410
+هذه بلاقي إن أنا كل ما أدرس بشكل أدق بلاقي الجينات
+
+609
+01:00:52,410 --> 01:01:00,160
+موجودة بشكل متفاوت، مناطق ما لهاش قيمة ومناطق غنية
+
+610
+01:01:00,160 --> 01:01:04,900
+بالجينات اللي هي بتأثر فمثلًا على الـ Chromosome
+
+611
+01:01:04,900 --> 01:01:15,340
+11 اللي هو 135 ميجا يعني اللي هو تقريبًا مليون
+
+612
+01:01:15,340 --> 01:01:21,520
+Base of DNA فلمّا
+
+613
+01:01:21,520 --> 01:01:27,990
+تيجي على الـ يعني هذه القطع بعدين بيسموها في One
+
+614
+01:01:27,990 --> 01:01:35,190
+و Two و Three و Four بيصير يسمي
+
+667
+01:07:14,220 --> 01:07:17,560
+لما نأخذ إحنا الـ DNA راح نشوف الأشياء بهذه
+
+668
+01:07:17,560 --> 01:07:27,600
+الطريقة، أي جين يتم بعدين نسخه حتى يتم التعرف على
+
+669
+01:07:27,600 --> 01:07:31,780
+أن هذا هو الجين، وإنه إحنا من هنا لازم نبدأ ننسخ
+
+670
+01:07:31,780 --> 01:07:38,580
+وبعدين كيف بدخل الأمور مع بعض، باللاقي أنه يعني بعد
+
+671
+01:07:38,580 --> 01:07:45,040
+طبعاً أنا في الـ strand أو في الجهة
+
+672
+01:07:45,040 --> 01:07:48,760
+اللي راح أنسخها من الـ five prime لـ three prime
+
+673
+01:07:48,760 --> 01:07:53,480
+يعني هذه، يعني قاعد نعتمد عليها، وهيك بيعتبروها
+
+674
+01:07:53,480 --> 01:08:00,030
+أنه بالأول في promoter region، يعني فيه لازم يكون في
+
+675
+01:08:00,030 --> 01:08:05,850
+سلسلة الأحرف هذه، فيه شيء معين أو قطعة معينة أو
+
+676
+01:08:05,850 --> 01:08:12,550
+ترتيب معين يكون يعني يساعدنا ويساعد عملية الـ
+
+677
+01:08:12,550 --> 01:08:17,150
+Transcription، أنه تبدأ من هذا المكان حتى يطلع عندي
+
+678
+01:08:17,150 --> 01:08:21,170
+البروتين اللازم أو الـ RNA اللازم اللي بحتاجه
+
+679
+01:08:21,170 --> 01:08:28,230
+ففي عندي الـ Start of Transcription، يعني هنا في شيء
+
+680
+01:08:28,230 --> 01:08:33,390
+لما نبدأ عملية الـ Transcription، بتروح، بتدور على
+
+681
+01:08:33,390 --> 01:08:40,870
+هذه القطعة حتى إنها تبدأ من هنا، يعني إذا الواحد بياخد
+
+682
+01:08:40,870 --> 01:08:44,090
+شرح عملية الـ Transcription، Translation، يعني مشابه
+
+683
+01:08:44,090 --> 01:08:49,850
+الواحد بسحاب البنطلون أو سحاب الجاكيت أو الشيء
+
+684
+01:08:49,850 --> 01:08:54,950
+يعني فبدنا شيء بالأول نميزه، إنه أنا بدي أبدأ حتى
+
+685
+01:08:55,450 --> 01:08:58,970
+يتوافق هذا مع هذا بشكل جيد،
+إنه أنا بدي أبدأ من هذا
+
+686
+01:08:58,970 --> 01:09:04,350
+المكان، بالنسبة للجينات، ليس بالضرورة أن يكون الـ
+
+687
+01:09:04,350 --> 01:09:12,470
+Protein ناتج عن قطعة متصلة من الـ DNA، أحياناً أكثر
+
+688
+01:09:12,470 --> 01:09:19,150
+من قطعة يتم استخدامها، وبالتالي، لما نتكلم على أي
+
+689
+01:09:19,150 --> 01:09:25,890
+بيتكلم على أي بروتين هنا، مثلاً هناك ما يسمى الـ
+
+690
+01:09:25,890 --> 01:09:31,050
+Exon والـ Intron، الـ Intron هي القطع الـ
+
+691
+01:09:31,050 --> 01:09:34,430
+intervening sequences اللي لن يتم الاستفادة منها
+
+692
+01:09:34,430 --> 01:09:39,330
+وبالتالي يعني لما أنا بدي أقول البروتين الحقيقي
+
+693
+01:09:39,330 --> 01:09:44,190
+على مستوى الـ DNA، بيكون بهذا الشكل، طويل شوية زيادة
+
+694
+01:09:44,190 --> 01:09:51,790
+يعني متسلسل، وهناك قطع من المنتصف لا يتم الاستفادة
+
+695
+01:09:51,790 --> 01:09:56,510
+منها، أحياناً، يعني زي هذا البروتين، الـ Introns
+
+696
+01:09:56,510 --> 01:10:00,890
+والـ Exons، والـ Exons تبعينه متصلة، يعني بهذا الشكل
+
+697
+01:10:00,890 --> 01:10:08,110
+ففي هذا المثال، الـ Codon،
+
+698
+01:10:08,110 --> 01:10:12,630
+الـ Initiator Codon، راح نحكي عنه بعد شوية، اللي
+
+699
+01:10:12,630 --> 01:10:16,950
+راح يبدأ عملية الـ Transcription، وراح يكون هذا
+
+700
+01:10:16,950 --> 01:10:21,450
+اللي بدنا نأخذه، هذا راح نقطعه وما بدنا إياه، بناخد هذا
+
+701
+01:10:21,450 --> 01:10:24,290
+القطعة، وبعدين بنقطع هذا الجزء، وبعدين بناخد هذا
+
+702
+01:10:24,290 --> 01:10:28,050
+الجزء، وبعدين بنقطع هذا الجزء، بهذه الطريقة لحد ما
+
+703
+01:10:28,050 --> 01:10:34,510
+ننهي المطلوب منه، فهذه الظاهرة بتتم، أنه على مستوى
+
+704
+01:10:34,510 --> 01:10:41,510
+الـ DNA، ما يتم، يعني أحياناً بتكون هذه الظاهرة على
+
+705
+01:10:41,510 --> 01:10:47,400
+مستوى الـ RNA، وبعدين اللي هي القص واللصق فيها، بس
+
+706
+01:10:47,400 --> 01:10:54,160
+لازم يكون بالأول شيء يظهر لبدء عملية الـ
+
+707
+01:10:54,160 --> 01:10:58,500
+Transcription، إنه أبدأ من هذه النقطة، Initiator
+
+708
+01:10:58,500 --> 01:11:03,680
+Codon، و Termination Codon لوقف عملية نسخ تبع الـ
+
+709
+01:11:03,680 --> 01:11:11,220
+DNA إلى Messenger RNA أو إلى الـ RNA، ولأنواع مختلفة بتلاقي
+
+710
+01:11:11,220 --> 01:11:16,810
+على الكروموزومات المختلفة، بتلاقي الجينات بهذا الشكل، بكون
+
+711
+01:11:16,810 --> 01:11:21,410
+أنا بقرأ أشياء ما لهاش قيمة، ما لهاش معنى كثير،
+
+712
+01:11:21,410 --> 01:11:29,470
+وبعدين بدخل في مناطق بلاقي فيها مادة مفيدة لـ…
+
+713
+01:11:29,470 --> 01:11:34,670
+كجيناتها، فكان زمان يقدروا يمكن فيه خمسين لـ مئة ألف
+
+714
+01:11:34,670 --> 01:11:38,990
+جين، بس لما عملوا الـ Human Genome، وقروا
+
+715
+01:11:38,990 --> 01:11:42,390
+الـ Nucleotides واحد وراء الثاني، واحد وراء الثاني،
+
+716
+01:11:42,390 --> 01:11:45,860
+واحد وراء الثاني، لقينا، اللي هي الرقم اللي بيقدروه
+
+717
+01:11:45,860 --> 01:11:54,100
+الآن، من 22 ألف لـ 25 ألف جين، من خلال اللي هي إنه
+
+718
+01:11:54,100 --> 01:12:01,260
+واضح إنه هذه المنطقة فيها شيء راح ينقره، أيوة، إيه
+
+719
+01:12:01,260 --> 01:12:05,900
+أسئلة؟ تفضلي، ليش
+
+720
+01:12:05,900 --> 01:12:06,520
+السؤال؟
+
+721
+01:12:12,050 --> 01:12:17,970
+دكتور أحمد، في سؤال، إن شاء الله الأمور واضحة، أجل
+
+722
+01:12:17,970 --> 01:12:31,670
+فضلًا، دكتورة أيناس، إذا عندك سؤال، يبدو
+
+723
+01:12:31,670 --> 01:12:38,650
+أن هناك سؤال، فإن شاء الله الأمور واضحة الآن، يعني
+
+724
+01:12:38,650 --> 01:12:42,810
+هذه، نرجع مرة ثانية، لما واحد يتعامل مع الـ DNA
+
+725
+01:12:42,810 --> 01:12:47,550
+والوراثة بهذا الشكل، مصطلح Transcription،
+
+726
+01:12:47,550 --> 01:12:53,050
+Translation، Protein Assembly، وصف الخطوات هذه، يجب
+
+727
+01:12:53,050 --> 01:13:00,290
+أن يكون الواحد فاهماً، حكينا
+
+728
+01:13:00,290 --> 01:13:05,230
+الـ DNA اللي هو الـ Double Helix اللي يتم قراءته
+
+729
+01:13:05,230 --> 01:13:14,800
+هو اللي من خمسة لثلاثة، ماشي، فبتم
+
+730
+01:13:14,800 --> 01:13:20,500
+دايماً قراءة واحد من الـ Double Helix، ما يتم قراءة
+
+731
+01:13:20,500 --> 01:13:27,240
+اثنين، بتكون من جهة واحدة، بيكون من خمسة لثلاثة، الـ
+
+732
+01:13:27,240 --> 01:13:35,740
+Transcription، بنتج عنها اللي هو الـ، يعني يسمونه
+
+733
+01:13:35,740 --> 01:13:43,400
+الـ nascent أو الـ RNA الأولي، ماشي، وبكون عندي
+
+734
+01:13:43,400 --> 01:13:47,180
+فيه بالأول اللي هو "Start-up Codon" وفيه
+
+735
+01:13:47,180 --> 01:13:51,220
+"Termination Codon"، حتى نعرف إنه أنا بحاجة إن أعمل
+
+736
+01:13:51,220 --> 01:13:55,660
+Transcription للقطعة هذه وأكملها، بيبدأ النظام زي
+
+737
+01:13:55,660 --> 01:14:00,360
+سحاب، يمسك واحد واحد، كل واحد من الـ Nucleotides
+
+738
+01:14:00,360 --> 01:14:05,000
+يقراه، شو هو، ويعطينا المكافئ تبعه، حسب قواعد
+
+739
+01:14:05,000 --> 01:14:10,020
+التزاوج أو التكافؤ، بحيث إنه بنبدأ من هون، وبتكون هي
+
+740
+01:14:10,020 --> 01:14:14,140
+ظاهرة لأنه أنا احتجت إني أنسخ هذا الـ DNA في هذه
+
+741
+01:14:14,140 --> 01:14:18,760
+القطعة، فتبدأ من هنا وبتظل تكتمل لحد ما تشوف شيء
+
+742
+01:14:18,760 --> 01:14:24,900
+يقول وقف، فلما تصل هنا بوقف، فهذا يطلع اللي هو
+
+743
+01:14:24,900 --> 01:14:31,540
+الـ Primary RNA، الـ Primary RNA فيه الـ Exons اللي هم
+
+744
+01:14:31,540 --> 01:14:35,380
+هذول اللي تم الاستفادة منهم، وفيه إيش اسمه
+
+745
+01:14:35,380 --> 01:14:42,830
+الـ Intron اللي بالنص، الـ Intron بتتم قصهم، ولصق الـ
+
+746
+01:14:42,830 --> 01:14:51,630
+Messenger RNA بشكل متصل كامل، بحيث أنه بنسميها
+
+747
+01:14:51,630 --> 01:14:56,230
+the alternative، أو RNA Processing، أو Alternative
+
+748
+01:14:56,230 --> 01:15:00,950
+Splicing، بتسموه مرات، يعني قص ولصق على مستوى الـ
+
+749
+01:15:00,950 --> 01:15:08,920
+RNA، بحيث إنه القطع المطلوبة تمّ، يعني لصقها بشكل
+
+750
+01:15:08,920 --> 01:15:15,660
+متصل، بحيث يعطينا الـ Messenger RNA، المرحلة الأولى
+
+751
+01:15:15,660 --> 01:15:19,940
+بتكون في الـ Nucleus، هنا المفروض يرسموا لنا
+
+752
+01:15:19,940 --> 01:15:25,500
+الـ Nuclear Membrane، و الـ Pores، المسنجر RNA اللي هو
+
+753
+01:15:25,500 --> 01:15:32,580
+الكامل، بيطلع لبرا، فبيروح جوا الـ Cytoplasm، بيروح
+
+754
+01:15:32,580 --> 01:15:37,970
+بالذات على الـ Golgi Apparatus، بتتم عملية، بالذات الـ
+
+755
+01:15:37,970 --> 01:15:40,810
+Protein synthesis، عند الـ Rough endoplasmic
+
+756
+01:15:40,810 --> 01:15:46,030
+reticulum، اللي هي من تراكيب الخلية، وفيها بتتم عملية
+
+757
+01:15:46,030 --> 01:15:50,410
+بناء البروتين، بناء البروتين، إنه بيجي شيء
+
+758
+01:15:50,410 --> 01:15:58,970
+اسمه Ribosome، زي سنّ السحاب، بيبدأ يشبك على
+
+759
+01:15:58,970 --> 01:16:04,050
+Messenger RNA، ويكون هنا فيه، بيسموه Ribosome
+
+760
+01:16:04,050 --> 01:16:07,920
+الـ RNA، هذا الـ Messenger RNA، وبعدين بيجي الـ
+
+761
+01:16:07,920 --> 01:16:13,840
+Ribosome، الـ RNA، الـ Ribosome، الـ RNA، بطريقة معينة
+
+762
+01:16:13,840 --> 01:16:20,340
+بيكون فيه Transfer of RNA، بيشبك عليه الـ Amino
+
+763
+01:16:20,340 --> 01:16:30,340
+Acid، فالـ… مع سير الـ Ribosome على الـ Messenger
+
+764
+01:16:30,340 --> 01:16:36,460
+RNA، الـ Polypeptide Chain، اللي هي الـ "أحماض
+
+765
+01:16:36,460 --> 01:16:41,080
+الأمينية"، تتشبك وراء بعض، one after another، بيصير تشبك
+
+766
+01:16:41,080 --> 01:16:44,600
+وراء بعض، وبالتالي كل ما يقرأ أكثر بيعطينا حجم
+
+767
+01:16:44,600 --> 01:16:50,040
+البروتين أكبر، بحيث إنه بالأخير بنتج عندي البروتين
+
+768
+01:16:50,040 --> 01:16:55,100
+وبعدين بسوي البروتين Assembly بهذا الشكل، فهذه
+
+769
+01:16:55,100 --> 01:17:01,460
+الظواهر بتتم، يعني إحنا هنا بنصف بشكل أدق، وتفصيلي
+
+770
+01:17:02,230 --> 01:17:09,490
+مجمل الظواهر في كيفية تحويل المعلومات والشفرة اللي
+
+771
+01:17:09,490 --> 01:17:13,470
+موجودة في الـ DNA، بحيث إنه بالأخير تعطيني الـ
+
+772
+01:17:13,470 --> 01:17:18,230
+Protein اللي أنا بحتاجه أو تحتاجه هذه الخلية، بحيث إنه
+
+773
+01:17:18,230 --> 01:17:23,310
+راح يكون بالأول عملية unfolding of the DNA، وبعدين
+
+774
+01:17:23,310 --> 01:17:27,810
+for the transcribed strand، عملية الـ Transcription
+
+775
+01:17:28,640 --> 01:17:33,420
+وفيه اللي هي Start و فيه End و فيه Poly-A-Addition
+
+776
+01:17:33,420 --> 01:17:38,500
+بالأخير، حتى يكون نهاية، وبعدين بيصير عملية تنظيف
+
+777
+01:17:38,500 --> 01:17:42,660
+للـ RNA على مستوى الـ RNA، حيث إنه بيعطينا
+
+778
+01:17:42,660 --> 01:17:46,240
+الـ Messenger RNA، بيطلع في الـ… سواء Rough end
+
+779
+01:17:46,240 --> 01:17:49,640
+-plasmic reticulum، نسميها Rough end-plasmic
+
+780
+01:17:49,640 --> 01:17:52,920
+reticulum، لأنها بيكون فيها، لما واحد يشوف
+
+781
+01:17:52,920 --> 01:17:58,920
+الـ Ribosomes هذه، بيشوفها، بيخلي المظهر مش Smooth، مش
+
+782
+01:17:58,920 --> 01:18:07,840
+هيك يعني، مُجَعْعَلَقْ، يعني، فبتصير عملية الـ Translation
+
+783
+01:18:07,840 --> 01:18:14,880
+اللي بتعطيني الـ Protein Assembly، فهي الظواهر اللي
+
+784
+01:18:14,880 --> 01:18:18,260
+بتتم، وهي كلها علوم يعني أنتم أخذتوها أصلاً
+
+785
+01:18:18,260 --> 01:18:23,160
+بالثانوية العامة أو بالمدارس، وشغلات يعني مشهورة، بس
+
+786
+01:18:23,160 --> 01:18:28,090
+الواحد يكون فاهماً عنها، دكتور، في سؤال من أحمد بخصوص
+
+787
+01:18:28,090 --> 01:18:32,530
+القضية اللي هو اتجاه عملية الـ Transcription، تكون
+
+788
+01:18:32,530 --> 01:18:37,870
+من المبين في الصورة، فعلاً، من الـ 3' إلى الـ 5'، هو
+
+789
+01:18:37,870 --> 01:18:41,310
+عملية اللي هو الـ Transcription على الـ DNA، لكن
+
+790
+01:18:41,310 --> 01:18:45,150
+عملية الـ Translation صارت من الـ 5' إلى الـ 3'
+
+791
+01:18:45,490 --> 01:18:51,390
+للـ RNA، فهو بيسأل… بالله أنا اللي بقرا أنه الـ
+
+792
+01:18:51,390 --> 01:18:55,040
+Transcription Direction من 5 إلى 3، بس انبهر في
+
+793
+01:18:55,040 --> 01:18:57,200
+الصورة، أنه هو الـ "تجارب" – اللي بيكون غلط في
+
+794
+01:18:57,200 --> 01:19:02,740
+الرسم، أحياناً ممكن تلاقي الرسومات غلط، فدايماً يعني
+
+795
+01:19:02,740 --> 01:19:05,460
+سواء في الـ transcription أو بتوقع حتى في
+
+796
+01:19:05,460 --> 01:19:11,000
+الـ replication، الآليات إنك أنت بتبدأ من الـ يعني
+
+797
+01:19:11,000 --> 01:19:15,220
+الـ strand that is transcribed بيكون من الخمسة
+
+798
+01:19:15,220 --> 01:19:22,860
+لثلاثة، هيك بفهمه، يعني هنا خمسة "برايم" لثلاثة
+
+799
+01:19:22,860 --> 01:19:27,800
+"برايم"، هيك بالفعل، ماشي، فالـ "strand" الموجود
+
+800
+01:19:27,800 --> 01:19:32,200
+هنا اللي تم، يعني النسخ منه من الـ اللي هو
+
+801
+01:19:32,200 --> 01:19:35,820
+الـ "DNA"، كان الـ "strand" اتجاه النسخ عليه من
+
+802
+01:19:35,820 --> 01:19:40,440
+ثلاثة "برايم" لخمسة "برايم"، يعني هي شوية confusing
+
+803
+01:19:40,440 --> 01:19:47,680
+هنا، أنا يعني خليني يعني أقول لك، اللي كل الـ… أو
+
+804
+01:19:47,680 --> 01:19:51,640
+يعني كثير من المرات بيكتبوها، يعني إنه في
+
+805
+01:19:51,640 --> 01:19:56,140
+الـ Reference Strand، وفي الـ… كيف نتكلم مع الـ Strand
+
+806
+01:19:56,140 --> 01:20:01,300
+وكيف بدنا نترجم، يعني لما شوفت الصورة اللي اختلفنا
+
+807
+01:20:01,300 --> 01:20:05,660
+عليها شوية، في الخمس أشخاص اللي كنا عنها، Reference
+
+808
+01:20:05,660 --> 01:20:11,060
+Strand، وكده، إنه دايماً نمشي من الـ 5' إلى الـ 3'،
+
+809
+01:20:11,060 --> 01:20:14,160
+يعني هي كمية… هو المقصود، على حسب ما أذكر أنا
+
+810
+01:20:14,160 --> 01:20:19,260
+برضه، المقصود إنه إنشاء نسخة من الـ DNA اللي هو
+
+811
+01:20:19,260 --> 01:20:23,960
+أساساً non-transcribed strand، يعني الهدف إنه أنا
+
+812
+01:20:23,960 --> 01:20:27,260
+آخذ نسخة من الـ non-transcribed strand اللي هو من
+
+813
+01:20:27,260 --> 01:20:31,720
+5' إلى 3'. فأنا عشان هيك بنسخ من الـ strand
+
+814
+01:20:31,720 --> 01:20:37,580
+المقابل، اللي هو من 3' إلى 5'. شوف هاي معلومة دقيقة
+
+815
+01:20:37,580 --> 01:20:42,500
+كثير كثير كثير، يمكن ما لهاش فائدة كثير، بس بشكل عام
+
+816
+01:20:42,500 --> 01:20:50,080
+لما نحكي عن ترتيب الـ Nucleotides ومواقعها، يعني
+
+817
+01:20:50,080 --> 01:20:56,900
+أنت أساساً لما تأخذ، بعدين، راح نتكلم على تسمية طفرة
+
+818
+01:20:56,900 --> 01:21:02,380
+معينة، فهيقول لك G مثلاً، اللي هو يعني الـ Amino Acid
+
+819
+01:21:02,380 --> 01:21:03,320
+الأولاني
+
+820
+01:21:05,620 --> 01:21:11,920
+بديل برقم 100، بعدين C مثلاً نفترض بهذا الشكل، المئة
+
+821
+01:21:11,920 --> 01:21:18,060
+هذه اللي بدك تأخذها، إنه أنت بتقرأ القطعة من الـ
+
+822
+01:21:18,060 --> 01:21:22,280
+DNA، ولا الـ Transcription، ولا الـ كذا، راح تقراها
+
+823
+01:21:22,280 --> 01:21:26,340
+من الخمسة إلى الثلاثة، بدك تأخذها بهذا الشكل، فاهم
+
+824
+01:21:26,340 --> 01:21:31,650
+عليك كيف؟ فهذه الصورة هي عملية النسخ، إنه أنا لما
+
+825
+01:21:31,650 --> 01:21:37,870
+أنسخ الـ strand اللي هو بيكون مقابل للـ strand
+
+826
+01:21:37,870 --> 01:21:41,190
+الأصلي، أو خليني نسميه الـ strand اللي أنا بدي منه
+
+827
+01:21:41,190 --> 01:21:46,570
+نسخة، هم اثنين، اسمعي، اسمعي، حسناً، أنت لما يكون
+
+828
+01:21:46,570 --> 01:21:53,570
+عندك السلسلتين من DNA ملتصقتين مع بعض، ماشي، تمام، تفصلهم،
+
+829
+01:21:53,570 --> 01:21:59,430
+صح؟ إذا بدي أعمل DNA replication، شو راح أسوي؟
+
+830
+01:21:59,430 --> 01:22:04,470
+الجهتين، كل واحد، راح أحط المقابل له، طبعاً
+
+831
+01:22:04,470 --> 01:22:06,250
+طبعاً طبعاً طبعاً طبعاً طبعاً طبعاً
+
+832
+01:22:06,250 --> 01:22:06,710
+طبعاً طبعاً طبعاً طبعاً طبعاً طبعاً
+
+833
+01:22:06,710 --> 01:22:07,430
+طبعاً طبعاً طبعاً طبعاً طبعاً طبعاً
+
+834
+01:22:07,430 --> 01:22:12,550
+طبعاً طبعاً طبعاً طبعاً طبعاً طبعاً
+
+835
+01:22:12,550 --> 01:22:21,110
+طبعاً طبعاً
+
+836
+01:22:22,650 --> 01:22:27,160
+واللي بي
+
+889
+01:26:56,550 --> 01:27:01,370
+جزء منه إنه الـTelomere اللي هو الـ«تلي» يعني
+
+890
+01:27:01,370 --> 01:27:07,890
+بعيد أو مطرف، فالـTelomere فيه عبارة عن زي مسبحة
+
+891
+01:27:07,890 --> 01:27:12,990
+أو حبات مسبحة، كيف خير، في طرف الـChromosome بحيث
+
+892
+01:27:12,990 --> 01:27:18,560
+إنه مع كل انقسام حبة بتطير، حبة بتطير، حبة بتطير، فلما
+
+893
+01:27:18,560 --> 01:27:23,540
+أنا بفترض تقديراً يعني، بتوقع يمكن ما بعرفش رقم 100
+
+894
+01:27:23,540 --> 01:27:28,420
+% حوالي 60 حبة، لأنه يقال إن الخلايا تنقسم 60 مرة
+
+895
+01:27:28,420 --> 01:27:33,040
+ولمّا تنقسم 60 مرة هذا بتعطينا كمية مهولة جداً من
+
+896
+01:27:33,040 --> 01:27:40,560
+الخلايا، يعني إشي كبير جداً، فالـTelomere لما يعني
+
+897
+01:27:40,560 --> 01:27:45,780
+تسمع في الكتب أو في الدراسات يقول لك والله النعجة
+
+898
+01:27:45,780 --> 01:27:53,840
+دوللي صحيح ولدت من خلية أمها، اللي هي يعني ولدت اليوم
+
+899
+01:27:53,840 --> 01:28:00,680
+بس حقيقة يعني، الأم كانت مثلاً نفترض زي مثلاً نفترض
+
+900
+01:28:00,680 --> 01:28:06,900
+بشر، إنسان عمره ثلاثين سنة، واخدت منه خلية نقلتها في
+
+901
+01:28:06,900 --> 01:28:11,820
+استنساخ، عملت خلية ثانية وكائن بشري ثاني، الطفل أو
+
+902
+01:28:11,820 --> 01:28:16,130
+الإنسان هذا لما يولد عمره ثلاثين، مش عمره يوم، يعني
+
+903
+01:28:16,130 --> 01:28:21,590
+ما يعني إذا الإنسان بعيش سبعين سنة، الانقسامات
+
+904
+01:28:21,590 --> 01:28:25,710
+الباقية له اللي هي أربعين سنة، عشان هيك المعجز دول
+
+905
+01:28:25,710 --> 01:28:31,450
+ماتت مبكراً، شيخوها مبكراً، لأنه قليتها عمرها كبير
+
+906
+01:28:31,450 --> 01:28:37,570
+بسبب إنه الـ… شو اسمه؟ قليتها عمرها كبير بسبب إنه
+
+907
+01:28:37,570 --> 01:28:44,350
+الـ… الـ… شو اسمه؟ الـTelomeres، قليلة لأن
+
+908
+01:28:44,350 --> 01:28:48,570
+المسبحة انقسم منها كثير بالانقسامات القديمة، يعني
+
+909
+01:28:48,570 --> 01:28:54,750
+بهذا الشكل بدنا نفهمه، واضح؟ إن شاء الله يكون
+
+910
+01:28:54,750 --> 01:28:59,930
+الجواب يعني وصل إلى الدكتورة أسماء، الدكتورة هذه
+
+911
+01:28:59,930 --> 01:29:03,410
+اللي بتقول يعني الـPolar Body، خلية فيها Cytoplasm
+
+912
+01:29:03,410 --> 01:29:08,230
+قليل، يعني نعم، صحيح، وجاي على الطرف، يعني الجسم
+
+913
+01:29:08,230 --> 01:29:15,260
+القطبي، الـPolar يعني قطبي، صحيح؟ أه طبعاً، لحد الآن
+
+914
+01:29:15,260 --> 01:29:19,500
+الأسئلة هي كذلك، تم الإجابة عليها تقريباً ومعظمها
+
+915
+01:29:19,500 --> 01:29:24,880
+نقطة الأخيرة، واللي خلينا على الموضوع هذا طويل،
+
+916
+01:29:24,880 --> 01:29:29,080
+صارت الساعة عشرة، فموعدنا غداً إن شاء الله الساعة
+
+917
+01:29:29,080 --> 01:29:33,420
+ثمانية ونصف، ونبدأ من هذه النقطة بإذن الله تعالى، بس
+
+918
+01:29:33,420 --> 01:29:38,260
+بعد إذنك يا دكتور، إذا الـPowerPoint بالظبط ببعت لك
+
+919
+01:29:38,260 --> 01:29:44,060
+الآن محاضرتين، اليوم وبكرة إن شاء الله رب العالمين، بس
+
+920
+01:29:44,060 --> 01:29:48,320
+يبقى نفسي اللي في الكتاب، في الغالب ما جبتش إشي
+
+921
+01:29:48,320 --> 01:29:52,580
+خارجي، ماشي، ماشي، فيه بس بعد إذنك يا دكتور قبل ما
+
+922
+01:29:52,580 --> 01:29:57,300
+ننهي، فيه يعني كان اقتراح من بعض الطلاب بخصوص الـ
+
+923
+01:29:57,300 --> 01:30:04,400
+slides، لو يتم بس يعني كتابة بعض النقاط يعني بعد
+
+924
+01:30:04,400 --> 01:30:09,480
+الصور أو كذا، عشان تكون معينة يعني على خلال عملية
+
+925
+01:30:09,480 --> 01:30:13,500
+التدوين، في الشرح، المتابع للشرح، يعني بعض النقاط
+
+926
+01:30:13,500 --> 01:30:18,950
+الرئيسية اللي بتكلم عن كل صورة، اسمع علي، المرجع
+
+927
+01:30:18,950 --> 01:30:25,730
+بصراحة ثري جداً وعميق الأصل
+
+928
+01:30:25,730 --> 01:30:29,590
+يعني إذا الواحد ما عندهوش قدرة أو يمكن تفاصيل
+
+929
+01:30:29,590 --> 01:30:35,470
+المعلومات، هي جيدة، تكون مرجع لوحد مثلاً بده يعطي
+
+930
+01:30:35,470 --> 01:30:40,870
+المحاضرة أو بده يفهم نقطة محددة بشكل دقيق، يعني زي
+
+931
+01:30:40,870 --> 01:30:44,490
+اللي أختك بتفهم عن Polar Body بشكل أدق ولا كده
+
+932
+01:30:44,990 --> 01:30:50,290
+فبتلاقي يمكن فقرة جوا موجودة، أنا بعتبر إنه مدان ما
+
+933
+01:30:50,290 --> 01:30:56,210
+ركزت عليها، يعني إنها مش كتير مهمة لكم، يعني فالآن
+
+934
+01:30:56,210 --> 01:31:03,410
+اللي أنا بفضله إنه يعني كل محاضرة عبارة عن فصل من
+
+935
+01:31:03,410 --> 01:31:09,890
+الكتاب، الفصل هتلاقي فيه مقدمة، فيه جداول، فيه
+
+936
+01:31:09,890 --> 01:31:16,640
+الرسمات اللي بنعرضها، بالأخير فيه يعني ملخص، فأنا اللي
+
+937
+01:31:16,640 --> 01:31:21,840
+باقترحه إنه كمان الواحد يرجع للنقاط الرئيسية في
+
+938
+01:31:21,840 --> 01:31:30,020
+الكتاب اللي هي العناوين، الجداول، الصور، إذا إشي حاطط
+
+939
+01:31:30,020 --> 01:31:33,520
+بنت عليه عريض، هذه اللي الواحد، الأشياء اللي يركز
+
+940
+01:31:33,520 --> 01:31:39,900
+عليها، فأنتم كمان يعني، التفاريغ دائماً بقول كانت
+
+941
+01:31:39,900 --> 01:31:44,080
+مفيدة إلي لما أنا أكون اللي كتبتها، أن أنا بتذكر،
+
+942
+01:31:44,080 --> 01:31:47,940
+فاسمعوا كلامي وشوفوا الكتاب، ارجعوا هيك إليه
+
+943
+01:31:47,940 --> 01:31:52,180
+بسرعة، لا تضيعوا وقتكم كثير في تفاصيل المعلومات
+
+944
+01:31:52,180 --> 01:31:58,120
+الخط الصغير، المعلومات الكثيرة، يعني هي بتعينك على
+
+945
+01:31:58,120 --> 01:32:02,180
+الفهم بشكل اللي يعني من خلال زي ما أنا بقول هيك،
+
+946
+01:32:02,180 --> 01:32:07,870
+بشرح كيف تظهر هذا بالتمثيل أو كيف كذا، أما التفاصيل
+
+947
+01:32:07,870 --> 01:32:13,190
+مش راح تكون يعني، إذا الواحد فهم المبدأ والقاعدة
+
+948
+01:32:13,190 --> 01:32:17,830
+زي ما بيقولوا بيقدر يتذكر الأشياء بإذن الله تعالى،
+
+949
+01:32:17,830 --> 01:32:20,490
+إن شاء الله رب العالمين، يعطيك العفو يا دكتور، الله
+
+950
+01:32:20,490 --> 01:32:23,530
+يرضى عليكم، بنروح نقتل إن شاء الله، إن شاء الله رب
+
+951
+01:32:23,530 --> 01:32:27,470
+العالمين، نكمل من هنا، السلام عليكم، السلام عليكم،
+
+952
+01:32:27,470 --> 01:32:28,010
+في رعاية الله
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/QjHQ6ziYtVc_postprocess.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/QjHQ6ziYtVc_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..a443ac47dc0302966ae8c3886c9acb3d4d6b19eb
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/QjHQ6ziYtVc_postprocess.srt
@@ -0,0 +1,3809 @@
+1
+00:00:00,000 --> 00:00:07,320
+بسم الله الرحمن الرحيم في المحاضرة السابقة كنا
+
+2
+00:00:07,320 --> 00:00:15,780
+نتكلم عن تركيب الـ DNA والمادة الأورافية وكيف هي
+
+3
+00:00:15,780 --> 00:00:24,980
+موجودة في خلايانا ووصلنا ووقفنا شوية عند هذه
+
+4
+00:00:24,980 --> 00:00:29,840
+الصورة واتناقشنا فيها شوية، اللي هييعني حاطين فيها
+
+5
+00:00:29,840 --> 00:00:36,520
+مبادئ إنه داخل الـ Chromosome بيكون الـ DNA على
+
+6
+00:00:36,520 --> 00:00:41,920
+شكل اللي هو الـ Double Helix السلم اللولبي وإنه
+
+7
+00:00:41,920 --> 00:00:48,360
+لما نحنا نيجي نتعامل معاه دائما ناخد الأصل اللي
+
+8
+00:00:48,360 --> 00:00:53,630
+يكون اللي هو القطعة اللي ماشية من الجهةالـFive
+
+9
+00:00:53,630 --> 00:00:58,150
+Prime لـThree Prime يعني بترتيب معين طبعاً لأن
+
+10
+00:00:58,150 --> 00:01:03,710
+الـDouble Helix الدرجات تبعاته عبارة عن الـPurine
+
+11
+00:01:03,710 --> 00:01:07,870
+و البريميدين نوعين من القواعد النيتروجينية
+
+12
+00:01:07,870 --> 00:01:15,110
+وبالتالي كل واحد بيرتبط مع نوع آخر محدد يعني ففي
+
+13
+00:01:15,110 --> 00:01:21,390
+أي موقع بكون أنا عندي أربع احتمالات الـC و الـG و
+
+14
+00:01:21,390 --> 00:01:27,660
+الـA و الـTوبالتالي المكافئة
+
+15
+00:01:27,660 --> 00:01:33,960
+له بيكون محددة، طريقة محددة فالصورة
+
+16
+00:01:33,960 --> 00:01:41,660
+هذه سببت إشكالية شوية اللي هي إنه إحنا لما نتعامل
+
+17
+00:01:41,660 --> 00:01:47,760
+مع الـ «DNA» ومن هدول الأحرف الأربعةالواحد من
+
+18
+00:01:47,760 --> 00:01:53,000
+الأربعة إنه عشر أقصد تسعة ثلاثة في عشر أقصد تسعة
+
+19
+00:01:53,000 --> 00:01:57,680
+وتلت مليارات نيتروجين
+
+20
+00:01:57,680 --> 00:02:05,150
+أسبايس أو Nucleotidesوبكونوا لما نتعامل معها في
+
+21
+00:02:05,150 --> 00:02:13,490
+حالات قراءتها في القراءتها في الـ…. في أي خلية أو
+
+22
+00:02:13,490 --> 00:02:16,870
+في خلية بني آدم معين زي ما سوّينا في الـHuman
+
+23
+00:02:16,870 --> 00:02:23,030
+Genome طلعنا ما يسمى في مأي موقع معين، في Gen معين
+
+24
+00:02:23,030 --> 00:02:26,790
+أنا مهتم فيه، بقول، بطلع الـReference Sequence
+
+25
+00:02:26,790 --> 00:02:32,080
+وهذا اللي بعتمده من خلالالـ Human Genome Project
+
+26
+00:02:32,080 --> 00:02:38,000
+هذا بعتبره المرجع بالنسبة لي فإذا أنا بعمل دراسة
+
+27
+00:02:38,000 --> 00:02:42,780
+معينة وهي فرضية أو افتراض في حالة معينة إنه أنا
+
+28
+00:02:42,780 --> 00:02:47,160
+جيت أركز بسبب المرض أو الحالة أو الإشي اللي أنا
+
+29
+00:02:47,160 --> 00:02:53,480
+بدرسه فيه جيت درست مجموعة أشخاص الشخص الأول الصدفة
+
+30
+00:02:53,480 --> 00:02:56,900
+هيك أو طلع معاه إنه طلعت تماما زي الـReference
+
+31
+00:02:56,900 --> 00:03:02,630
+Sequence وكان هذا الشخص الأولفي الشخص الثاني
+
+32
+00:03:02,630 --> 00:03:07,550
+والثالث كان فيه تبديل في أحد القواعد النيتروجينية
+
+33
+00:03:07,550 --> 00:03:11,890
+وهذا بيصير ومش كل الناس زي بعض عشان هيك أحنا
+
+34
+00:03:11,890 --> 00:03:19,350
+مختلفين فبتلاقوا الواحد في الموقع هذا بدل ما هي
+
+35
+00:03:19,350 --> 00:03:25,850
+جاي T صار C نيكليوتايد أو nitrogenous base فهذا
+
+36
+00:03:25,850 --> 00:03:32,150
+إنسان مختلف بشكل بسيطحتى بيسموهم Snips Single
+
+37
+00:03:32,150 --> 00:03:37,270
+Nucleotide Polymorphisms يعني إنه فيه اختلاف في
+
+38
+00:03:37,270 --> 00:03:41,770
+حرف واحد من الأحرف الأربعة في موقع معين والشخص
+
+39
+00:03:41,770 --> 00:03:46,810
+التاني والتالت في هذا الموقع متشابهين الشخص الرابع
+
+40
+00:03:46,810 --> 00:03:52,690
+في عنده تبديل آخر في موقع آخر في حرف آخر ممكن تحدث
+
+41
+00:03:52,690 --> 00:03:59,140
+بهذه الطريقة والشخص الخامس كان عنده إنهطول الـ DNA
+
+42
+00:03:59,140 --> 00:04:03,800
+في هذا الموقع أقصر بحيث أنه صار فيه إزالة لإنواعين
+
+43
+00:04:03,800 --> 00:04:11,740
+وهذه يعني كأنها تمثل نوع من يعني لما يجي الطبيب أو
+
+44
+00:04:11,740 --> 00:04:16,700
+العالم أو الباحث يجي يدرس موقع معين لمرض معين أو
+
+45
+00:04:16,700 --> 00:04:21,000
+لحالة معينة ويدرس مجموعة من البشر ويلاقي هذه
+
+46
+00:04:21,000 --> 00:04:26,960
+الاختلافات بهذا الشكل لا تعني شيءيعني من ناحية
+
+47
+00:04:26,960 --> 00:04:32,300
+الآن إنه ناخدها إنه هذا يمثل مرض أو نتيجتها كذا أو
+
+48
+00:04:32,300 --> 00:04:39,700
+كذا يعني بس بقدر ما إنها هي أمثلة لطريق
+
+49
+00:04:39,700 --> 00:04:45,180
+دراسة الـ DNA بالأيام الحالية إنه دائما نستخدم الـ
+
+50
+00:04:45,180 --> 00:04:51,710
+PCR بحيث إنه نطلع شو الترتيب الحالي للـأحرف تبعات
+
+51
+00:04:51,710 --> 00:05:00,210
+الـ Nucleotides أو الـ DNA وكذلك النقطة اللي بعدها
+
+52
+00:05:00,210 --> 00:05:03,610
+إنه
+
+53
+00:05:03,610 --> 00:05:09,210
+22 أو 23 زوج من الكرموزومات 22 متشابقة جسمية
+
+54
+00:05:09,210 --> 00:05:18,210
+تقريبًا يعني حسب الـ Graph هذاكل ما يعني هو
+
+55
+00:05:18,210 --> 00:05:26,150
+تقريبًا ذكرنا فيه حوالي 25 ألف جين
+
+56
+00:05:26,150 --> 00:05:32,050
+في الـHuman Genome هذا تقديرهم حسب الـHuman Genome
+
+57
+00:05:32,050 --> 00:05:37,830
+Project فتقريبًا إنه الإنسان يقدر إنه في كل
+
+58
+00:05:37,830 --> 00:05:42,390
+كروموزوم فيه حوالي ألف تقريبًا بس فيه تفاوض شديد
+
+59
+00:05:42,390 --> 00:05:48,100
+يعني الكروموزوم رقم واحديعني بنلاقي في آخر الـ
+
+60
+00:05:48,100 --> 00:05:53,380
+«جدوس» الـ «جراف» هذا في أعلى شيء حجمه أكبر شيء
+
+61
+00:05:53,380 --> 00:05:59,900
+حوالي 250 ميجابيز يعني مليون قاعدة بهذا الشكل
+
+62
+00:05:59,900 --> 00:06:07,960
+ويقدر أنه في حوالي 2000 جين عدد الجينات أو القطع
+
+63
+00:06:07,960 --> 00:06:15,610
+اللي تحول إلى بروتين فـهكذا ترتيب وتوزيع الـ… الـ…
+
+64
+00:06:15,610 --> 00:06:22,170
+الـ«كروموزومات» تبع الـDNA في النواة وطبعًا بنلاحظ
+
+65
+00:06:22,170 --> 00:06:27,010
+أنه في الـX والـY كروموزومات الـX هو الأكبر واللي
+
+66
+00:06:27,010 --> 00:06:36,190
+فيه جينات أكثر الـY فقير للجينات يعني حوالي ممكن
+
+67
+00:06:36,190 --> 00:06:41,890
+خمسين جين أو عدد قليل من الجينات وهذه تمت دراستها
+
+68
+00:06:41,890 --> 00:06:42,510
+سابقًا
+
+69
+00:06:45,000 --> 00:06:50,340
+محاضرة الاستكمال، محاضرة اليوم نبدأ بوصف الظواهر
+
+70
+00:06:50,340 --> 00:06:56,660
+اللي بتحدث إنه نتيجة تكاثر الجسم وتكون الإنسان
+
+71
+00:06:56,660 --> 00:07:02,940
+اتداعاً من خلية واحدة اللي هي الـFertilized Egg من
+
+72
+00:07:02,940 --> 00:07:08,280
+أولها إلى آخر يوم في حياته يكون هناك انقسام في
+
+73
+00:07:08,280 --> 00:07:12,120
+الخلايا وهناك نوعين من انقسام وكلها معلومات
+
+74
+00:07:12,120 --> 00:07:18,430
+تعرفوهاإذا في حد عنده أي استفسار يوقفني وإذا
+
+75
+00:07:18,430 --> 00:07:24,390
+الأمور واضحة بنكمل الانقسام
+
+76
+00:07:24,390 --> 00:07:31,530
+على نوعين فيه الانقسام الجسماني أو الانقسام اللي
+
+77
+00:07:31,530 --> 00:07:36,330
+هو الـ Mitotic باللغة الإنجليزية وهناك الـ Meiosis
+
+78
+00:07:36,330 --> 00:07:42,430
+اللي هو الانقسام المنصف فالانقسام للخلايا العادية
+
+79
+00:07:43,250 --> 00:07:50,590
+بكون أنهم يعني توصف بأنها تمر في cell cycle في
+
+80
+00:07:50,590 --> 00:07:58,230
+دورة حياة الخلية فأنها تكون تؤدي وظائفها وتعمل حسب
+
+81
+00:07:58,230 --> 00:08:04,770
+أنواع مختلفة من الخلايا بتكون بالـ G1 phase يعني
+
+82
+00:08:04,770 --> 00:08:08,570
+اللي هي في مرحلة أنها تكون خلية عادية تقوم
+
+83
+00:08:08,570 --> 00:08:11,530
+بوظيفتها حسب الاشي المطلوب منها
+
+84
+00:08:14,460 --> 00:08:22,280
+النواة بيكون المادة الوراثية فيها زي الخيط الفالد
+
+85
+00:08:22,280 --> 00:08:29,660
+وما في داعي يكون مربوط أو مكور بشكل مضغوط حتى يتم
+
+86
+00:08:29,660 --> 00:08:37,380
+عملية الانقسام عند حدوث أو تهيأ لبداية الانقسام
+
+87
+00:08:39,710 --> 00:08:48,090
+بتم يعني بعد ما تكون في حالة الـG1 تدخل في المرحلة
+
+88
+00:08:48,090 --> 00:08:53,350
+ما تسمى الـS phase وهي المرحلة اللي يتم فيها إعادة
+
+89
+00:08:53,350 --> 00:09:01,550
+أو مضاعفة تكوين الـDNA والكرموزومات بشكل كامل بحيث
+
+90
+00:09:01,550 --> 00:09:06,330
+أنه تصبح للخلية نسختين من المادة الوراثيةالـ
+
+91
+00:09:06,330 --> 00:09:12,830
+Chromosome يعني بشكل مهم حتى يشترك في هذه العملية
+
+92
+00:09:12,830 --> 00:09:20,970
+بيكون يصبح على شكل مضغوط ويكون على شكل يعني قطعة
+
+93
+00:09:20,970 --> 00:09:27,550
+الـ الـ الـ DNA الملفوف بشكل شديد ومضغوط ويلديه
+
+94
+00:09:27,550 --> 00:09:34,640
+حتى يتم فصله على جهتين الخليتين المفصلات بعدينبكون
+
+95
+00:09:34,640 --> 00:09:41,580
+عنده «سينترومير» اللي هو النقطة عليه التي يتم جذب
+
+96
+00:09:41,580 --> 00:09:50,420
+الكرمزومين المتشابهين إلى زاويتين خلايتين متكونتين
+
+97
+00:09:50,420 --> 00:09:55,100
+جديدتين فالـ «سينترومير» هذا وظيفته بيشبك مع الـ
+
+98
+00:09:55,100 --> 00:09:58,970
+«Spindle» للـ «سينتروزونز» على الجوانبوهناك ما
+
+99
+00:09:58,970 --> 00:10:06,130
+يسمى التلومير التلومير هي يعني بدك تشبهها بمسبحة
+
+100
+00:10:06,130 --> 00:10:13,310
+على طرف ونهاية الكرموزومات التلومير حد بيقدر يقول
+
+101
+00:10:13,310 --> 00:10:23,130
+إنه عشان أفهم إنه اللي معاي سامعيني واضح التلومير
+
+102
+00:10:23,130 --> 00:10:29,420
+إيه له قصة يعنييعني بيجيزوا يعني جيد الواحد يتنبه
+
+103
+00:10:29,420 --> 00:10:38,280
+لها الـ Telomere يعني يقدر يعني هذا التقدير أنه
+
+104
+00:10:38,280 --> 00:10:45,600
+الخلايا من بداية تكون النطفة المخصبة أو الـ
+
+105
+00:10:45,600 --> 00:10:50,880
+Fertilized Egg أنه تمتلك حوالي ستين مرة من القدرة
+
+106
+00:10:50,880 --> 00:10:56,870
+على الإنقسام وهذا العدد الإنقسامات هذه الستينإثنين
+
+107
+00:10:56,870 --> 00:11:02,550
+لعشرة، إثنين لأس ستين، إذا بتتذكروا قصة اللي اخترع
+
+108
+00:11:02,550 --> 00:11:06,730
+لعبة
+
+109
+00:11:06,730 --> 00:11:12,290
+الشطرانج أنه طلب للملك طلب الملك اللي قلّه اطلب
+
+110
+00:11:12,290 --> 00:11:18,030
+اللي بدكيا واطمناه بله بسيطة بدي تحطلي حبة قمح في
+
+111
+00:11:18,030 --> 00:11:24,300
+أول مربع في الـ 64 مربعوبعدين تحطي لي حبتين قمح
+
+112
+00:11:24,300 --> 00:11:29,660
+بالمربع الثاني أو أربع حبات ويضاعف كل مرة فثبت إنه
+
+113
+00:11:29,660 --> 00:11:34,820
+يعني كل إنتاج العالم من القمح لن يكفي لتغطية هذا
+
+114
+00:11:34,820 --> 00:11:40,740
+الطلب فـ 60 انقسام يعني كمية مهولة جدا ينتج عنها
+
+115
+00:11:40,740 --> 00:11:47,860
+ما بديش أقول مليارات المليارات من الخلايا فحتى يتم
+
+116
+00:11:47,860 --> 00:11:53,210
+التحكم بهذا الأمرفي نهاية الكروموزوم يكون هناك مثل
+
+117
+00:11:53,210 --> 00:12:00,350
+المسبحة فيها ستين حبة بحيث مع كل انقسام بتطير حبة
+
+118
+00:12:00,350 --> 00:12:04,610
+من المسبحة هذه بحيث عشان هيك يعني دراسة الـ
+
+119
+00:12:04,610 --> 00:12:12,010
+Telomere في أول كائن مستنسخ من خلية يعني جبوها
+
+120
+00:12:12,010 --> 00:12:17,960
+بطريقة مختلفة اللي هي النعجة «دولي»كتبت إنه حتى
+
+121
+00:12:17,960 --> 00:12:23,760
+عند ولادتها هي تقريبًا بمثل عمر إمها بسبب إن الـ
+
+122
+00:12:23,760 --> 00:12:30,460
+Telomere تبعها كان أقصر فهذا جانب مهم للتحكم
+
+123
+00:12:30,460 --> 00:12:35,780
+في العملية الكلية لقضية انقسام الخلايا في الجسم
+
+124
+00:12:35,780 --> 00:12:41,340
+فهناك ما يسمى الـ Telomeresدكتور، بعد إذنك، في
+
+125
+00:12:41,340 --> 00:12:45,760
+سؤال من الدكتور «أسديهان» بخصوص وظيفة الـ
+
+126
+00:12:45,760 --> 00:12:53,280
+«سينترومير» «سينترومير» هو المركز اللي يعني احنا
+
+127
+00:12:53,280 --> 00:13:01,100
+راح .. هون إذا بتنتبه الخلية هذه كانت واحدة تضاعف
+
+128
+00:13:01,100 --> 00:13:07,500
+الـ DNA اللي فيها فبعد ذلك انقسمت نص إلى خليتين
+
+129
+00:13:08,350 --> 00:13:12,810
+والسبب في الانقسام أنه هناك راح يكون حاجة نحكي
+
+130
+00:13:12,810 --> 00:13:17,370
+عنها «سينتروزوم» مش «سينترومير»، «سينتروزوم» بيكون
+
+131
+00:13:17,370 --> 00:13:23,150
+بالطرف من الجهتين الخليتين اللي راح يتكونوا وراح
+
+132
+00:13:23,150 --> 00:13:30,830
+يتم جد الـ «كرومزومات» أو الـ «كروماتيد» لكل طرف
+
+133
+00:13:30,830 --> 00:13:35,790
+عن طريق اللي هم يعني الـ Spindle Fibers بقولهم
+
+134
+00:13:36,280 --> 00:13:39,620
+وبيشبكوا ما بين الـ Centrosome مع الـ Centromere
+
+135
+00:13:39,620 --> 00:13:51,280
+حتى يفصل الـ DNA إلى نصفين متساوية، واضحة؟ فالـ
+
+136
+00:13:51,280 --> 00:13:58,420
+Centromere هو قطعة في الـ DNA، في الـ Chromosome
+
+137
+00:13:58,420 --> 00:14:06,510
+وظيفتها تسهيل والتحكم في عملية فصل نصفيالـ
+
+138
+00:14:06,510 --> 00:14:13,330
+Chromosomes إلى طرفي الخلية المنقسمة، ماشي؟ لسه
+
+139
+00:14:13,330 --> 00:14:16,370
+برضه النقطة يبدو أنها ما واضحة تقريبا راح نشوفها
+
+140
+00:14:16,370 --> 00:14:21,010
+بعدين بشكل تفصيلي، يعني الآن مش راسمينها، بس راح
+
+141
+00:14:21,010 --> 00:14:26,550
+تيجي مرة ثانية، ماشي؟ راح نشوفها كثير، إشي ضروري
+
+142
+00:14:26,550 --> 00:14:34,030
+عشان نقدر نفصلهم، يعني إذا أنا مثلا عندي Top 10
+
+143
+00:14:34,030 --> 00:14:40,220
+خيطوبدي أفصلهم عن بعض، لازم من مكان معين أمسكهم
+
+144
+00:14:40,220 --> 00:14:45,040
+عشان أجرهم للجهتين المختلفتين، فهذا المكان في
+
+145
+00:14:45,040 --> 00:14:49,820
+الـChromosome هو الـCentromere، وإله أشياء وبعدين
+
+146
+00:14:49,820 --> 00:14:58,840
+تاخدوها في الطب السريري يعني، ماشي، فالآن لما
+
+147
+00:14:58,840 --> 00:15:08,950
+نتكلم على دواهر أو تسمي أخرىبتكون الخلايا في الـ
+
+148
+00:15:08,950 --> 00:15:19,170
+G1 يعني هنا الـ G1 حاطينه بهذا الشكل اللي هو
+
+149
+00:15:19,170 --> 00:15:24,350
+الخلية في المرحلة تبعتها بتمر في مرحلة إحنا ما
+
+150
+00:15:24,350 --> 00:15:28,070
+بنشوفها اللي هي الـ S-phase للاستعداد لعملية
+
+151
+00:15:28,070 --> 00:15:34,450
+الانقسام بتتم فيها عملية إعادةأو مضاعفة كمية
+
+152
+00:15:34,450 --> 00:15:40,950
+الـDNA لما يتضاعف الخلية تصبح لديها ضعف كمية
+
+153
+00:15:40,950 --> 00:15:47,090
+الـDNA تبدأ تدخل في عملية الانقسام فالانقسام بيتم
+
+154
+00:15:47,090 --> 00:15:52,430
+في حملة الـG2 أو بعد ما تدخل الـG2 تكتر تحت شوية
+
+155
+00:15:52,430 --> 00:15:58,130
+تبدأ تدخل في الـmitosis الـmitosis اللي هو
+
+156
+00:15:58,130 --> 00:16:04,500
+الانقسام الطبيعيبتبدأ بالـ Interphase، تدخل بالـ
+
+157
+00:16:04,500 --> 00:16:07,480
+Prophase، وبعدين Pro-Metaphase، Metaphase،
+
+158
+00:16:07,480 --> 00:16:13,060
+Anaphase، Telophase، وبعدين Cytokinesis، تنقسم
+
+159
+00:16:13,060 --> 00:16:21,660
+شوية المراحل، بدنا نشوف الظواهر التالية هنا صار
+
+160
+00:16:21,660 --> 00:16:28,120
+عندي ضعف كمية الـ DNA فلما تبدأ عملية الانقسام،
+
+161
+00:16:28,120 --> 00:16:35,690
+أول شيءالـ Centrosomes تظهر يعني بتتكوّر بشكل أقوى
+
+162
+00:16:35,690 --> 00:16:42,710
+وأوضحه بدي إثنين منهم الخطوة التالية إنه بعد ما
+
+163
+00:16:42,710 --> 00:16:50,610
+كان الخيط أو الـ DNA فالت وطويل وغير ظاهر داخل
+
+164
+00:16:50,610 --> 00:17:00,010
+النواء يتم تكتيفه والتواءه على بعض بحيث يكوّنالـ
+
+165
+00:17:00,010 --> 00:17:03,870
+Chromatids والـ Chromosomes بالشكل اللي ابنراها
+
+166
+00:17:03,870 --> 00:17:09,590
+هنا لما يبدوا يظهروا تبدأ أن الخلية هذه مستعدة
+
+167
+00:17:09,590 --> 00:17:14,290
+لعملية الإنقسام وتسمى هذه مرحلة الـ Prophase بيصير
+
+168
+00:17:14,290 --> 00:17:19,330
+أن الـ Ocentrosome يظهر الـ Chromatin أو الـ
+
+169
+00:17:19,330 --> 00:17:25,050
+Chromosomes تظهر بعد ما كانت القيوط فارقة بتصير
+
+170
+00:17:25,050 --> 00:17:34,150
+تندغط وبعد ذلكيزول غلاء غشاء النواعي الـNuclear
+
+171
+00:17:34,150 --> 00:17:41,950
+Membrane بيختفي فهذه الظواهر اللي بتحدث أو بتبدأ
+
+172
+00:17:41,950 --> 00:17:46,330
+تحدث بالـProphase الـProphase بعدها بتدخل
+
+173
+00:17:46,330 --> 00:17:52,170
+بالـPrometaphase بيصير Indicator عليه إنه
+
+174
+00:17:52,170 --> 00:17:58,550
+الـCentrosomes تتجه إلى الطرفين في الخليةيعني
+
+175
+00:17:58,550 --> 00:18:04,350
+بيروحوا من هون وهون والـ «Chromatids» والـ
+
+176
+00:18:04,350 --> 00:18:12,290
+«Chromosomes» بتبدأ ترتبط من خلال أو يعني بواسطة
+
+177
+00:18:12,290 --> 00:18:18,470
+أو من محل الـ «Centrosomes» اللي آسف «Centromeres»
+
+178
+00:18:18,470 --> 00:18:22,810
+اللي حكت أنا زي ما سألت أنا قبل شوية هي المنطقة
+
+179
+00:18:22,810 --> 00:18:26,890
+اللي هتربط باللي هيسمى الـ «Spindle Fibers» إبارة
+
+180
+00:18:26,890 --> 00:18:34,780
+عنتقريبًا خيوط عضلية مركباتها تشبه العضلات فالـ
+
+181
+00:18:34,780 --> 00:18:40,760
+Centrosomes بيربطوا بالـ Centromere من خلال الـ
+
+182
+00:18:40,760 --> 00:18:45,040
+Spindle Fibers ففي
+
+183
+00:18:45,040 --> 00:18:51,520
+الـ Pro Metaphase تبدأ الظاهرة تتكون أكثر والـ
+
+184
+00:18:51,520 --> 00:18:56,740
+Chromosomes بتتشكل بشكل مضغوط جدًاوبشكل، بهذا
+
+185
+00:18:56,740 --> 00:19:02,960
+الشكل الذي نراه ولمّا حتى يتم عملية فصلهم إلى
+
+186
+00:19:02,960 --> 00:19:11,880
+الطرفين ونقطتين بتصير عملية الـMetaphasis إنه أنا
+
+187
+00:19:11,880 --> 00:19:20,080
+برتب كل زوج من الكروموزومات لأن هنا بتصير الـ…
+
+188
+00:19:20,080 --> 00:19:26,310
+الـ… الـ… الـDNA يُقال له «4N»يعني عندي ضعف كمية
+
+189
+00:19:26,310 --> 00:19:33,550
+الـ DNA فكل قطعتين متشابهات يقفوا بالنص في مستوى،
+
+190
+00:19:33,550 --> 00:19:38,810
+في نص الخلية ويكون على الطرفين الـ Centrosomes
+
+191
+00:19:38,810 --> 00:19:43,310
+ودولة اسمهم Spindle Fibers ويكون عندي الـ
+
+192
+00:19:43,310 --> 00:19:48,290
+Chromosomes بالنص فهدولة بيسموها Microtubules يعني
+
+193
+00:19:48,290 --> 00:19:55,480
+اللي هم زي خيوط العضلية بعد ذلك يبدأ شدالكرموزومات
+
+194
+00:19:55,480 --> 00:20:02,440
+للطرفين فهذه مرحلة الـ Anaphase فـInterphase،
+
+195
+00:20:02,440 --> 00:20:05,700
+Prophase، Prometaphase، Metaphase، Anaphase،
+
+196
+00:20:05,700 --> 00:20:11,300
+Telophase وبعدين تنقسم الخلية فبتم عملية الشد
+
+197
+00:20:11,300 --> 00:20:17,720
+للطرفين لما تنتهي وتصبح كل مجموعة الكرموزومات في
+
+198
+00:20:17,720 --> 00:20:24,410
+جهةتبدأ الـ Telophase إنه الخلية بتبدأ تنقسم تتخصر
+
+199
+00:20:24,410 --> 00:20:30,250
+في المنتصف وبعدين تنقسم إلى خليتها بعدها بيرجع
+
+200
+00:20:30,250 --> 00:20:36,270
+لشعر نواء ظاهر بيتكوّن مرة ثانية وبرجع الـ DNA يفك
+
+201
+00:20:36,270 --> 00:20:42,050
+وبتصير Decondensed كروماتين يعني الكرومازومات غير
+
+202
+00:20:42,050 --> 00:20:50,690
+مضغوطةهذا الإنقسام الطبيعي وبكون نتيجته إنه كل
+
+203
+00:20:50,690 --> 00:21:01,110
+خلية لديها 2N-DNA لديها DNA متشابه
+
+204
+00:21:01,110 --> 00:21:07,870
+تمامًا وبكون يعني مطابق للـDNA اللي كان موجود في
+
+205
+00:21:07,870 --> 00:21:13,010
+الخلية الأصلية فهذه الظاهرة في عملية الإنقساموأي
+
+206
+00:21:13,010 --> 00:21:18,910
+خلية بتنقسم وهذه كلها يعني معرفة المعلومات هذه
+
+207
+00:21:18,910 --> 00:21:23,630
+اللي دخل في حتى معرفة الأدوية معرفة الأمراض معرفة
+
+208
+00:21:23,630 --> 00:21:28,350
+الأشياء بعد ذلك يعني ما يخرب الـMicrotubules اللي
+
+209
+00:21:28,350 --> 00:21:32,330
+هم الـConscious من الأدوية اللي نستخدم للنقرص
+
+210
+00:21:32,330 --> 00:21:36,850
+واللي نستخدمه في أدوية كثيرة بتلاقيها تاريخهم يؤثر
+
+211
+00:21:36,850 --> 00:21:40,940
+على الـMicrotubulesفي مرات الـ Antibody تتكون
+
+212
+00:21:40,940 --> 00:21:47,400
+تدوسنترومير اللي هو موجود في منتصف الكروموزوم
+
+213
+00:21:47,400 --> 00:21:51,140
+Anticentromere Antibody في الـ Crest أو
+
+214
+00:21:51,140 --> 00:21:58,640
+درماتوميوسايتس أو أنواع من الأمراض تكون موجودة
+
+215
+00:21:58,640 --> 00:22:06,310
+فيها فالـ Mitosis هي الإنقسامالحقيقي وليس من
+
+216
+00:22:06,310 --> 00:22:10,950
+انتصاب المنصق المنصق، راح نحكي عنه بعد شوية ويكون
+
+217
+00:22:10,950 --> 00:22:16,870
+بهذه الطريقة، في أسئلة؟ في سؤال من الدكتورة هديل،
+
+218
+00:22:16,870 --> 00:22:23,670
+بخصوص ليش «4N»؟ لربما المقصود يعني قصد عدد اللي هو
+
+219
+00:22:23,670 --> 00:22:26,750
+اللي لها بلايد وديبلايد واشياء اللي زيها؟ أه، كمية
+
+220
+00:22:26,750 --> 00:22:36,830
+الـDNA، الأن الإنسان الطبيعيحكينا عنده 23 زوج فإذا
+
+221
+00:22:36,830 --> 00:22:42,090
+افترضنا نصهم أو كمية الـ «DNA» اللي موجودة في
+
+222
+00:22:42,090 --> 00:22:47,450
+الخلية الطبيعية في أي مرحلة بنقول عنها، نمثلها
+
+223
+00:22:47,450 --> 00:22:55,830
+أنها «2N» لأنه في نسختين فالـ الـ طبعاً نسختين،
+
+224
+00:22:55,830 --> 00:23:02,110
+نصفها من الأب ونصفها من الأمحتى يتم عملية الإنقسام
+
+225
+00:23:02,110 --> 00:23:08,510
+بدها تظهر خلية البنت أو الناتجة تماثل تمامًا
+
+226
+00:23:08,510 --> 00:23:14,570
+الخلية الأم تبعتها فحتى يتم هذا الأمر لازم في لحظة
+
+227
+00:23:14,570 --> 00:23:21,430
+معينة يتم عملية تكتير الـDNA يعني مضاعفته اللي هي
+
+228
+00:23:21,430 --> 00:23:24,890
+الـS-phase فاحنا بنكون بالـG1 phase هي الخلية
+
+229
+00:23:24,890 --> 00:23:33,370
+العادية الـDNA لما نحكي عنها46 كروموزوم DNA كامل
+
+230
+00:23:33,370 --> 00:23:38,350
+بالوصف اللي بنصفه إحنا بنكون نصف الـ DNA تبع هذه
+
+231
+00:23:38,350 --> 00:23:44,230
+المرحلة فحتى يتم عملية الإنقسام لازم بالأول يتم
+
+232
+00:23:44,230 --> 00:23:49,370
+عملية مضاعفة الـ DNA ففي الـ G2 الخلية في هذه
+
+233
+00:23:49,370 --> 00:23:54,450
+المرحلة بكون ضاعفة الـ DNA تبعتها فصار أربعة N
+
+234
+00:23:54,450 --> 00:24:01,510
+فصار عندها أربع أبعادكمية الـ DNA يعني من المفردة
+
+235
+00:24:01,510 --> 00:24:06,810
+اللي هي راح نشوف موجودة في الـ Spares والـ Eggs
+
+236
+00:24:06,810 --> 00:24:14,810
+اللي هما في الانقسام الثاني فهو نتوءًا، الـ S
+
+237
+00:24:14,810 --> 00:24:21,230
+بضاعف الـ CR4M بنقسم في الـ Mitosis بهذه الطريقة،
+
+238
+00:24:21,230 --> 00:24:27,960
+برجع توءًاهذه المصطلحات اللي بيستخدمها لكمية الـ
+
+239
+00:24:27,960 --> 00:24:34,140
+DNA اللي موجودة، واضح؟ في سؤال آخر يا دكتور بخصوص
+
+240
+00:24:34,140 --> 00:24:41,040
+الـ نعم اللي هو الـ microtubule، الشو بتفرج عن الـ
+
+241
+00:24:41,040 --> 00:24:45,360
+spindle fiber؟ هم spindle fiber هم نفسهم، هم
+
+242
+00:24:45,360 --> 00:24:50,220
+نفسهم، عبارة عن يعني بالأخير أكتين وميوسين، يعني
+
+243
+00:24:50,220 --> 00:24:57,590
+زي العضلات، إيش عشان يجد؟عشان يعني يخلّي الخلية
+
+244
+00:24:57,590 --> 00:25:04,810
+تنقسم لإن الـ DNA ينقسم ففي خيوط تبدأ من الـ
+
+245
+00:25:04,810 --> 00:25:11,630
+Centrosome على الطرف تصل لـ Centromere في نص الـ
+
+246
+00:25:11,630 --> 00:25:19,720
+Chromosome حتى تشده لطرفين، ماشي؟في برضه سؤال من
+
+247
+00:25:19,720 --> 00:25:27,020
+عمر بخصوص يعني إنه عدد الـN يعني الـA's، بقول حرف
+
+248
+00:25:27,020 --> 00:25:31,960
+الـN بيمثل عدد الـDNA و لا كمية الكرموسومات؟ كمية
+
+249
+00:25:31,960 --> 00:25:38,400
+الكرموسومات، هيك بعتبرهم على أساس نسربهم لبعض، one
+
+250
+00:25:38,400 --> 00:25:45,200
+N اللي موجود في الـspare أو في الـegg، راح ناخده
+
+251
+00:25:45,200 --> 00:25:49,520
+بعد شويةففي الخلية العادية اللي بتقوم في الشغل،
+
+252
+00:25:49,520 --> 00:25:54,600
+بكون عندى «2N»، بس بعد ما تخلص الـ «S» تدخل، بتكون
+
+253
+00:25:54,600 --> 00:25:58,560
+أنها في مرحلة «4N»، اللي هي بالـ «G2»، وبعدين
+
+254
+00:25:58,560 --> 00:26:02,940
+بتسوي عملية الإنقسام. فهو بعينك بيقول، يعني هل جيت
+
+255
+00:26:02,940 --> 00:26:08,640
+لما تصير «4N»، بيصير عدد الأزواج يعني 64 زوج؟ آه،
+
+256
+00:26:08,640 --> 00:26:12,400
+نعم، لأ، شو 64؟ لأ، مش 64، أنا استغربت من السؤال،
+
+257
+00:26:12,400 --> 00:26:17,370
+لأ، 46 زوج، صحيح؟46 زوج بدأت تضربهم بـ2 كمان يعني
+
+258
+00:26:17,370 --> 00:26:24,310
+تصير 92 زوج صحيح واضح يا طارق إن شاء الله بخصوص
+
+259
+00:26:24,310 --> 00:26:29,970
+السؤال اللي سألته الآن
+
+260
+00:26:29,970 --> 00:26:36,310
+من التجارب اللي أجرتها وكنت أسويها زمان واحنا طلاب
+
+261
+00:26:36,310 --> 00:26:40,530
+حتى إذا كان عندنا مجال نعملها اللي هو فحص بهذا
+
+262
+00:26:40,530 --> 00:26:48,740
+الشكل بنسميهالـ Karyotype الـ Karyotype إنه أول
+
+263
+00:26:48,740 --> 00:26:53,460
+شيء إحنا يعني
+
+264
+00:26:53,460 --> 00:26:58,000
+بنعطي الدواء لهو الـ Colchicine لحيث أنه يخرب الـ
+
+265
+00:26:58,000 --> 00:27:04,180
+Spindle Fibers وفي حالة ما ناخد الخلايا في مرحلة
+
+266
+00:27:04,180 --> 00:27:10,280
+يعني أنا بعطي إشي بوقف انقسام الخلاياماشي، من إنه
+
+267
+00:27:10,280 --> 00:27:13,320
+بيخرب الـ Spindle Fibers أو الـ Microtubules
+
+268
+00:27:13,320 --> 00:27:19,100
+فبتوصل الخلية مستوى الـ Metaphase اللي بيكون في
+
+269
+00:27:19,100 --> 00:27:25,980
+الـ DNA على شكل أكبر شكل مضغوط فيه فأنا بخلّي الـ
+
+270
+00:27:25,980 --> 00:27:31,040
+الـ الـ الـ الـ DNA والكرمزومات تصبح شكل مضغوط
+
+271
+00:27:31,040 --> 00:27:37,530
+وبعد ذلك كنا نوقفحتى تظبط هذا الأمر نوقف على طاولة
+
+272
+00:27:37,530 --> 00:27:43,950
+على إيش يعني بارتفاع طويل ونلقي الخلية
+
+273
+00:27:43,950 --> 00:27:50,750
+أو الساقل اللي فيه الخلايا وفي لحظة معينة بتجدوا
+
+274
+00:27:50,750 --> 00:27:56,050
+صورة مثل هذه الصورة فهذا فحص يسمى Carry Time يتم
+
+275
+00:27:56,050 --> 00:27:59,670
+صبغ الـDNA بالجِمزة
+
+276
+00:28:02,810 --> 00:28:06,790
+Stain اللي هى بيسموه الـ G-banding بهذا الشكل
+
+277
+00:28:06,790 --> 00:28:12,390
+وبنتج عندى صورة بهذا الصور بقدر من خلالها أدرس
+
+278
+00:28:12,390 --> 00:28:19,450
+خواص و أدرس الـ chromosomes والـ DNA كله بشكل كامل
+
+279
+00:28:19,450 --> 00:28:25,450
+يعني كمجموعة كاملة موجودة في الخلية فهذه عبارة عن
+
+280
+00:28:25,450 --> 00:28:30,820
+أنه أنا وقفت القسام الخلية عند مرحلةالـ Metaphase
+
+281
+00:28:30,820 --> 00:28:37,700
+وبكون الـ DNA بأكبر شكل مضغوط فيه وبستخدم صبغة
+
+282
+00:28:37,700 --> 00:28:41,840
+وبحاول أزيدها بحيث تتناثر الـ Chromosomes شوية
+
+283
+00:28:41,840 --> 00:28:47,040
+بعيد عن بعض عايز أشوفها ولمّا أشوف الصورة هذه اللي
+
+284
+00:28:47,040 --> 00:28:52,320
+هي هذه بتكون مطبوعة على ورقة بجيب مقص و بقص الـ
+
+285
+00:28:52,320 --> 00:28:58,980
+Chromosomes و برتبها بهذا الشكلفأحيانًا، يعني كل
+
+286
+00:28:58,980 --> 00:29:02,900
+إثنين من الكرموزومات لازم يكونوا متشابهات وبدها
+
+287
+00:29:02,900 --> 00:29:10,660
+تخيل إن الإشي محطوط بشكل مظبوط فالـ «روموزومات»
+
+288
+00:29:10,660 --> 00:29:17,600
+واحد الـPairs اللي هم الـ22 وهنا ذكر الـXY
+
+289
+00:29:17,600 --> 00:29:24,800
+كرموزومات وبكون شكلهم بهذا الشكلفهذه تجربة أنا
+
+290
+00:29:24,800 --> 00:29:30,000
+كطالب طب كنا في الكويت سويتها وعملتها بيدي إني
+
+291
+00:29:30,000 --> 00:29:36,700
+أشوف وهذا يعني إذا بدكم إياها تفق مع مختبر اللي هو
+
+292
+00:29:36,700 --> 00:29:40,560
+بيسوي عملية فحص الجينات عن طريق بيقولوله فحص الـ
+
+293
+00:29:40,560 --> 00:29:45,840
+Karyotype هنا لا نستطيع يعني التكلم عن
+
+294
+00:29:45,840 --> 00:29:50,590
+الـIndividual Genesأحنا هنا نقدر مثلًا زي ما
+
+295
+00:29:50,590 --> 00:29:54,750
+تعرفوا تسمعوا «Down Syndrome» «Trisomy 21» إنه
+
+296
+00:29:54,750 --> 00:29:59,010
+بيكون بدل ما عندي مثلًا كروموزوم 21 بدل ما هم
+
+297
+00:29:59,010 --> 00:30:07,470
+اثنين، pair، بيكون عندي خلافة أو XXY مثلًا أو
+
+298
+00:30:07,470 --> 00:30:10,670
+«Trisomy» يعني راح نحكي على الكروموزوم
+
+299
+00:30:10,670 --> 00:30:14,090
+الـAnomalies وهدولة بيكونوا من خلال هذا الفحص اللي
+
+300
+00:30:14,090 --> 00:30:20,290
+بتسميه «Karyotype»فهذا أحد الفيقوسات وهذه هنا بهذا
+
+301
+00:30:20,290 --> 00:30:27,090
+الشكل هي Metaphase في الـ Mitosis بتكون يعني في
+
+302
+00:30:27,090 --> 00:30:31,750
+لحظة ما بتكون الـ DNA Condensed وهذه بتكون، شو
+
+303
+00:30:31,750 --> 00:30:37,470
+اسمها؟ بتكون يعني لدراسة الكرمозومات الموجودة والـ
+
+304
+00:30:37,470 --> 00:30:42,750
+G-banding يعني هو اللي نستفيد منه حتى أحيانًا في
+
+305
+00:30:42,750 --> 00:30:50,330
+وصفسواء الحالات أو وين الواحد يبحث أو شوه الأشياء
+
+306
+00:30:50,330 --> 00:30:54,670
+اللي بتكون موجودة يعني دايماً إحنا لما نرسم الـDNA
+
+307
+00:30:54,670 --> 00:31:00,750
+أو الـChromosome برسموه بهذا الشكل وعليه نطاقات،
+
+308
+00:31:00,750 --> 00:31:04,990
+عليه إشي أغمق، أفتح، كده، هذه بتساعد في عملية
+
+309
+00:31:04,990 --> 00:31:09,770
+الوصف وعملية التعامل
+
+310
+00:31:09,770 --> 00:31:14,490
+مع الـChromosome، في سؤال؟في سؤالة، يا دكتور،
+
+311
+00:31:14,490 --> 00:31:18,210
+بخصوص المادة، يعني الدكتورة أسمها بتسأل المادة
+
+312
+00:31:18,210 --> 00:31:20,830
+اللي بتوقف عملية الـmetaphase أو المقصر،
+
+313
+00:31:20,830 --> 00:31:24,210
+الـColchicine، أه الـColchicine، حكيتها، مخرب
+
+314
+00:31:24,210 --> 00:31:28,250
+الـSpindelfiber أو الـMicrotubules دولة، هذا
+
+315
+00:31:28,250 --> 00:31:31,730
+الـmechanism of action، يعتبر الـmain mechanism of
+
+316
+00:31:31,730 --> 00:31:35,510
+action، وده يستخدم شكل كبير، طبعاً الجرع بدأ تكون
+
+317
+00:31:35,510 --> 00:31:42,780
+مختلفة وبتحطوه على الـشو بيسموها، يعني الـالـ Cell
+
+318
+00:31:42,780 --> 00:31:48,260
+Culture يعني في الـ Environment تبع الخلية، فأه،
+
+319
+00:31:48,260 --> 00:31:53,180
+ماشي، يعني هذه تجربة بتسمى عملية الـ Karyotype
+
+320
+00:31:53,180 --> 00:31:59,020
+وهيك بتكون نتيجتها، بتكون إنها تظهر الكروموزومات
+
+321
+00:31:59,020 --> 00:32:04,960
+بشكل مضغوط ويتم صبغها بحيث تظهر فيها النطاقات أو
+
+322
+00:32:04,960 --> 00:32:09,860
+الـ Binding هذا، وهيستفاد منها في عملية دراسة
+
+323
+00:32:10,230 --> 00:32:15,130
+بالذات الأمراض الكروموزومية أو ما دون الكروموزوم
+
+324
+00:32:15,130 --> 00:32:20,650
+بس مش لجين واحد لأنه بالمتوسط كل كروموزوم فيه
+
+325
+00:32:20,650 --> 00:32:25,650
+حوالي ألف جين يعني عدد كبير من الجينة فبالتالي
+
+326
+00:32:25,650 --> 00:32:30,730
+يعني ما بتفيد لإيش دقيق إنما هيك بيكون لظاهرة
+
+327
+00:32:30,730 --> 00:32:34,970
+كبيرة كتير زي الـChromosomal Anomalies فاحنا بقعد
+
+328
+00:32:34,970 --> 00:32:35,830
+عنهم بعد شوية
+
+329
+00:32:38,690 --> 00:32:43,950
+فالـ … الـ إحنا يعني اللي بدنا نـ … يعني من
+
+330
+00:32:43,950 --> 00:32:51,130
+الظواهر نتكلم عنها إنه في حالة، في مرحلة معينة الـ
+
+331
+00:32:51,130 --> 00:32:58,790
+interface اللي بيكون فيه داخل الخلية بيكون هناك
+
+332
+00:32:58,790 --> 00:33:05,670
+جدار نواء وهناك يكون الـ DNA على شكل خط ثالث
+
+333
+00:33:06,370 --> 00:33:11,770
+فبالتالي خيط يعني حتى يتم نسخه لو تكوين
+
+334
+00:33:11,770 --> 00:33:18,630
+الـChromosomes فيه آسف ونسخه عمل الـRNA وتكوين
+
+335
+00:33:18,630 --> 00:33:23,130
+البروتينات منه بيكون ما يسمى Decondensed يعني
+
+336
+00:33:23,130 --> 00:33:30,750
+بيكون مش مضغوطفلما نبدأ في عملية الـ Mitosis لازم
+
+337
+00:33:30,750 --> 00:33:37,770
+هذا الـ DNA يتم لفه وربطه بشكل مضغوط جداً جداً في
+
+338
+00:33:37,770 --> 00:33:42,250
+الـ Prophase ويهيئه لعملية الـ Metaphase لما نوقف
+
+339
+00:33:42,250 --> 00:33:47,670
+بالنص ويتم فصله فدايماً في كل عملية انقسام خلية
+
+340
+00:33:48,660 --> 00:33:54,100
+الخيط الـ «DNA» اللي هو كان أصل خيط فالد طويل جداً
+
+341
+00:33:54,100 --> 00:34:02,040
+بتم لفه في ربطة يعني زي ضمة إحبال ملفوفة بشكل شديد
+
+342
+00:34:02,040 --> 00:34:07,080
+بحيث تقريباً تصبح جسم صلب أو جسم منفصي بحيث يتم
+
+343
+00:34:07,080 --> 00:34:12,640
+فصله لنسختين وبعدين يتم فكه مرة ثانية الـProphase
+
+344
+00:34:12,640 --> 00:34:17,040
+والـMetaphase بيكونش فيه غشاء نوع، بنشعل، وبعدين
+
+345
+00:34:17,040 --> 00:34:22,080
+برجع مرة ثانيةفهذه كلها ظواهر بتكون موجودة ولازم
+
+346
+00:34:22,080 --> 00:34:28,800
+واحد ينتبهها الـ… الـChromosome replication في
+
+347
+00:34:28,800 --> 00:34:34,860
+حالة اللي حكينا 4N، كيف بيكون؟ إذا افترضنا إنه
+
+348
+00:34:34,860 --> 00:34:42,380
+الـ… أنا بالأول كان عندي كرموزوم بهذا الشكل الـ…
+
+349
+00:34:42,380 --> 00:34:50,510
+الـ… الـN هنابدنا نتكلم، يعني ندخل على قضية
+
+350
+00:34:50,510 --> 00:34:55,110
+الانقسام المنصر اللي هو الـ Meiosis اللي هو بتتم
+
+351
+00:34:55,110 --> 00:35:04,510
+فيه بتكوين اللي هما الـSperm والـEgg
+
+352
+00:35:05,150 --> 00:35:10,570
+أيوة يا رُباط، احكوا في سؤال يا دكتور، يعني قبل ما
+
+353
+00:35:10,570 --> 00:35:13,430
+تسأل دكتور رُباط، في سؤال من دكتورة جمانة تقول
+
+354
+00:35:13,430 --> 00:35:19,470
+عملية النسخ بتصير في الـInterface، بس؟ لأ، بالـS،
+
+355
+00:35:19,470 --> 00:35:27,630
+النسخ هاي، اللي هي هنا يعني حتى لما نيجي بهذه
+
+356
+00:35:27,630 --> 00:35:35,450
+الظاهرة، ماشي، النسخ بتتم في هذه اللحظةاللي هي
+
+357
+00:35:35,450 --> 00:35:40,110
+بتكون الخلية بدأت في الـG1 بتكون شغالة أمان الله
+
+358
+00:35:40,110 --> 00:35:45,830
+بتقرر أو بتجيها أمر أو دافع إنها بدأت تنقسم أو
+
+359
+00:35:45,830 --> 00:35:51,270
+بحاجة تنقسم أول شي بتعمله بتضاعف كمية الـDNA
+
+360
+00:35:51,270 --> 00:35:56,570
+تبعتها ترتاحلها شوية بالـG2 phase وبعدين تبدأ تدخل
+
+361
+00:35:56,570 --> 00:36:01,350
+في الـmitosis اللي هي عملية الإنقسام فالانقسام من
+
+362
+00:36:01,350 --> 00:36:07,980
+2N ل4N بتتمفي الـ S-Phase وهنا أعطيكم إذا افترضنا
+
+363
+00:36:07,980 --> 00:36:14,700
+الخلية انقسمت خلال 24 ساعة مرة بتكون في الـG1 مثلا
+
+364
+00:36:14,700 --> 00:36:19,360
+نص النهار وبعدين بدها 6 ساعات أو آسف يعني انت
+
+365
+00:36:19,360 --> 00:36:26,280
+قريبا 12 ساعة ثانيات عشان تنقسم بالأول بتضاعف
+
+366
+00:36:26,280 --> 00:36:31,280
+الـDNA اللي هي الـS-Phase وبعدين بترتاح شويه
+
+367
+00:36:31,280 --> 00:36:36,340
+بالـG2يعني بتجهز على لإنها تبدأ الـ Mitosis،
+
+368
+00:36:36,340 --> 00:36:40,560
+وبعدين بتصوّر الـ Mitosis الـ Mitosis هذا، اللي هو
+
+369
+00:36:40,560 --> 00:36:46,640
+إنه بتكون Centrosomes وبصير الـ DNA والـ
+
+370
+00:36:46,640 --> 00:36:51,680
+Chromosomes هيك تتبين و تـ Condense، وبعدين الـ
+
+371
+00:36:51,680 --> 00:36:56,200
+Brometaphase بتبدأ يكون Spindle Fiber وبختفي الـ
+
+372
+00:36:56,200 --> 00:37:01,100
+Nuclear Membrane، وبعدين بالـ Metaphase بتصف بهذا
+
+373
+00:37:01,100 --> 00:37:06,270
+الشكلوبعدين بيتم جرّة DNA للطرفين وبعدين القسق
+
+374
+00:37:06,270 --> 00:37:11,350
+الخلية بتنتصف فده بترجع تكوّن الـ Nuclear Membrane
+
+375
+00:37:11,350 --> 00:37:19,090
+وبيفك الـ DNA وبيصير Uncondensed واضح؟ روبة؟ بدها
+
+376
+00:37:19,090 --> 00:37:24,470
+أي شيء؟ يبدو أنه ما عندها سؤال أو لم إجابة السؤال
+
+377
+00:37:24,470 --> 00:37:31,430
+بالنسبة للظاهرة الأخرى اللي هي عمليةالـ Meiosis
+
+378
+00:37:31,430 --> 00:37:36,930
+اللي هو الانقسام المنصف اللي هو إنه بنتج في الجميز
+
+379
+00:37:36,930 --> 00:37:44,390
+اللي هما الـ Sperm والـ Egg تبدأ
+
+380
+00:37:44,390 --> 00:37:50,930
+أيضًا يعني بتكون الـ Resting Cell أو الخلية
+
+381
+00:37:50,930 --> 00:37:57,750
+الأصلية بتكون عندنا كمية DNA معينة، ماشي نبدأ إنه
+
+382
+00:37:57,750 --> 00:38:04,680
+أول شيء الـ DNA بتضعفوبعدين بتنقسم على مرحلتين
+
+383
+00:38:04,680 --> 00:38:11,980
+المرحل الأولى بتصير كروموزوم واحد في كل جهة وبعدين
+
+384
+00:38:11,980 --> 00:38:17,640
+بنقسم نص الكروموزوم اللي هي الـHafloid Gametes
+
+385
+00:38:17,640 --> 00:38:25,180
+يعني بالأخير بكون 2N بوصل 4N بعطينا أربعة 1N
+
+386
+00:38:25,180 --> 00:38:32,280
+Gametes أو اللي هي Sperm أو Fertilizedفهذه خطوات
+
+387
+00:38:32,280 --> 00:38:38,100
+الـ Meiosis يعني بالأخير على مرحلتين ونتيجته إن
+
+388
+00:38:38,100 --> 00:38:43,320
+كمية الـ DNA بدأت تكون نص الكمية اللي هي 1N لأنه
+
+389
+00:38:43,320 --> 00:38:48,360
+بالكالية العادية بتكون 2N فالأمر
+
+390
+00:38:48,360 --> 00:38:55,080
+بتتم من خلال مرحلتين بتسميهم Meiosis I اللي هي
+
+391
+00:38:55,080 --> 00:39:00,120
+بهذا الشكل بتبدأ بـ Interphase بعدين بتروح لـ
+
+392
+00:39:00,120 --> 00:39:06,790
+Prophaseوبعدين متى phase one وانا phase one بحيث
+
+393
+00:39:06,790 --> 00:39:14,830
+انه بعطيني يعني اللي هما two يعني حسب راح ناخدهم
+
+394
+00:39:14,830 --> 00:39:20,530
+حسب الـ «وين» هل هي male ولا female بحيث بعطيني
+
+395
+00:39:20,530 --> 00:39:28,040
+الأخير الجامعي بدخل بعدين enter phase twoميتا فايز
+
+396
+00:39:28,040 --> 00:39:32,760
+تُو وأنا فايز تُو لقاد ما يعطينا الجامعات فهذه
+
+397
+00:39:32,760 --> 00:39:39,140
+خطوات الإنقسام المنصر بالترتيب هذا، interface،
+
+398
+00:39:39,140 --> 00:39:44,040
+بعدين، أيه أخدنا هنا Pro phase وميتا Pro phase،
+
+399
+00:39:44,040 --> 00:39:45,740
+وميتا Pro phase، وميتا Pro phase، وميتا Pro phase،
+
+400
+00:39:45,740 --> 00:39:45,900
+وميتا Pro phase، وميتا Pro phase، وميتا Pro phase،
+
+401
+00:39:45,900 --> 00:39:46,340
+وميتا Pro phase، وميتا Pro phase، وميتا Pro phase،
+
+402
+00:39:46,340 --> 00:39:48,360
+وميتا Pro phase، وميتا Pro phase، وميتا Pro phase،
+
+403
+00:39:48,360 --> 00:39:52,490
+وميتالـ Metaphase يعني عشان نتذكر لما نكون الـ
+
+404
+00:39:52,490 --> 00:39:55,750
+«كروموزوماتيك» مصففة بالنص وفيه عندي Two
+
+405
+00:39:55,750 --> 00:39:59,050
+Centrosomes وفيه عندي Spindle Fiber، هاي الـ
+
+406
+00:39:59,050 --> 00:40:02,370
+Metaphase وبعدها بتصير عملية الشد اللي يسميه
+
+407
+00:40:02,370 --> 00:40:06,130
+Anaphase فالنقطة
+
+408
+00:40:06,130 --> 00:40:14,070
+هنا في أي انقسام ماشي بالذات
+
+409
+00:40:14,070 --> 00:40:22,480
+يعني هنافي حالة اللي حكينا عنه الـ Meiosis اللي هو
+
+410
+00:40:22,480 --> 00:40:29,240
+الانقسام المنصر الـ Mitosis نفس الـ Chromosome
+
+411
+00:40:29,240 --> 00:40:34,500
+بيكون عنده من الـ Centromere تبعه بنفصلنا نصين
+
+412
+00:40:34,500 --> 00:40:43,020
+بيكونوا متشابهات إذا تخيلنا أنا عندي سلكين كتوال
+
+413
+00:40:43,020 --> 00:40:48,940
+أو لفتينحبل، ملفوفات وأنا باجي بحطهم مقبال بعض
+
+414
+00:40:48,940 --> 00:40:54,600
+وباجي بفصلهم إلا أحيانًا بيحدث إنه Recombination
+
+415
+00:40:54,600 --> 00:41:02,940
+يعني اللي هي إن الـ «DNA» يعني هناك آليات لقطع أو
+
+416
+00:41:02,940 --> 00:41:08,200
+إذا صار قطع إنه يصير عملية وصل مرة ثانية للقطع
+
+417
+00:41:08,200 --> 00:41:14,370
+فإذا أحيانًا حبلين أو سلكين التفن على بعضعشان
+
+418
+00:41:14,370 --> 00:41:20,490
+نفكهم مظبوط بتم عملية قطع وصل بحيث أنه أحيانًا بتم
+
+419
+00:41:20,490 --> 00:41:26,410
+عملية نقل المادة الوراثية من فرق إلى فرق آخر أو من
+
+420
+00:41:26,410 --> 00:41:31,570
+جهة إلى جهة أخرى أحيانًا نتيجة الـHomologous
+
+421
+00:41:31,570 --> 00:41:36,430
+Recombination الـMyosis Homologous يعني متساوي أو
+
+422
+00:41:36,430 --> 00:41:45,110
+متكافئ، ماشي؟ هنا بمعنى إنهاللي صار إنه القطع اللي
+
+423
+00:41:45,110 --> 00:41:49,530
+طارت من هون مشابه للقطع اللي طارت لهذه الجهة
+
+424
+00:41:49,530 --> 00:41:55,990
+الأخرى فهنا إذا ابتدينا بيعني هذا الـChromosome
+
+425
+00:41:55,990 --> 00:42:00,410
+اللي أخدته من والدي وهذا من والدتيوكانوا في حالة
+
+426
+00:42:00,410 --> 00:42:07,770
+الـ Meiosis وقفوا قبال بعض هذا الـGene، يعني مثلًا
+
+427
+00:42:07,770 --> 00:42:15,050
+نخد وصفة وفصيلة الدم الـHLA-type، وفصيلة كدا، أي
+
+428
+00:42:15,050 --> 00:42:20,070
+شيء بعد ما كان على كرموزوم معين ممكن تنتقل إلى
+
+429
+00:42:20,070 --> 00:42:26,030
+الكرموزوم الثاني والسبب أننا نتعامل مع خيط كان
+
+430
+00:42:26,030 --> 00:42:32,250
+الأصل فارد وطويللفناها، بس أحيانًا مع الالتفاف هذا
+
+431
+00:42:32,250 --> 00:42:36,690
+وتوقيفهم جانب بعض بيصير عملية أحيانًا انتقال
+
+432
+00:42:36,690 --> 00:42:41,450
+فأحيانًا الانتقال مش متساوي بتروح هنا قطعة تطلع
+
+433
+00:42:41,450 --> 00:42:45,230
+كبيرة وهنا تطلع قطعة صغيرة بس أحيانًا ممكن نكون
+
+434
+00:42:45,230 --> 00:42:52,550
+متكافئ تمامًا لأنه مظهريًا بالخارق الأخير القطعتين
+
+435
+00:42:52,550 --> 00:42:59,660
+متساويات في الحجمفي الـ «أندرذاكر» في الخصية
+
+436
+00:42:59,660 --> 00:43:07,180
+«Testis»، في «Spermatogoa»، بتمر بالـ «Meiosis I»
+
+437
+00:43:07,590 --> 00:43:13,370
+فـPrimary هون «Spermatogonium» لـ«Primary
+
+438
+00:43:13,370 --> 00:43:18,610
+Spermatocyte» و«Secondary Spermatocytes» بعدين
+
+439
+00:43:18,610 --> 00:43:23,210
+بدخل إشي بنسميه «Spermatids» لحد ما يعطينا
+
+440
+00:43:23,210 --> 00:43:33,610
+«Sperms» كان هنا الخلية «XY» يعني بتكون «2N» دخلت
+
+441
+00:43:33,610 --> 00:43:39,930
+بـ«4N» عطتنا «2N» لكل واحدةبس بعدين لما تنقسم من
+
+442
+00:43:39,930 --> 00:43:46,530
+القسام الثاني بتصير one M في كل صفير I عند الذكر
+
+443
+00:43:46,530 --> 00:43:52,250
+في القصير في المبيض عند الأنثى الـ ovary primary
+
+444
+00:43:52,250 --> 00:43:58,510
+of a side بتظلها خاملة لحد عند البلوغ وبعدين لما
+
+445
+00:43:58,510 --> 00:44:04,610
+تبدأ التورة بتصير أنSecondary Oocyte وMyotic
+
+446
+00:44:04,610 --> 00:44:10,590
+Spindle وFirst Polar Body بتاخد عنهم بعدين بحيث
+
+447
+00:44:10,590 --> 00:44:17,110
+أنه بتكون عندي الـ يعني هنا الـ Meiosis I اللي أنا
+
+448
+00:44:17,110 --> 00:44:22,110
+بتذكرها بحيث هنا الـ Meiosis II بحيث أنه ينتج عندي
+
+449
+00:44:22,110 --> 00:44:29,030
+بيضة واحدة بالنسبة لإذا مقارنتها بالذكر يعني هنا
+
+450
+00:44:29,030 --> 00:44:37,120
+كان2N مرحلة صار 4N وبالـ Meiosis 1 انتهى لـ2N
+
+451
+00:44:37,120 --> 00:44:44,720
+وMeiosis 2 صار 1N ان نتخيل انه في الأنثى الـ
+
+452
+00:44:44,720 --> 00:44:52,780
+Female بعد ما أصبح عندي 4N هذا الجزء تحول إلى ما
+
+453
+00:44:52,780 --> 00:44:58,570
+يسمونه Polar Body يعني خلية ميتة لأنهيعني في
+
+454
+00:44:58,570 --> 00:45:03,710
+الأنثى المطلوب بويضة واحدة فقط فما في داعي نكون
+
+455
+00:45:03,710 --> 00:45:09,530
+بويضات كثير فالـ الـ الـ الـ لما تمشي بالطريق راح
+
+456
+00:45:09,530 --> 00:45:13,590
+تمشي كأنه بطريق في هذا الشكل واحد فبما أنه
+
+457
+00:45:13,590 --> 00:45:17,950
+انقسامين، الانقسام الأول بيعطينا اسمه الـ First
+
+458
+00:45:17,950 --> 00:45:22,210
+Polar Body فهذا طبعا ما بتكونه، و بعدين لما تنقسم
+
+459
+00:45:22,210 --> 00:45:25,690
+من Two End لOne End برضه بتعطينا Polar Body ثاني
+
+460
+00:45:26,090 --> 00:45:31,870
+فزي ما هم شايفين هنا، بيحطوا إنه الـFertilized Egg
+
+461
+00:45:31,870 --> 00:45:36,810
+أو قبل الـFertilization، بدي يكون الـFirst Boiler
+
+462
+00:45:36,810 --> 00:45:41,130
+Body وبعدين الـSecond Boiler Body اللي هم يعني،
+
+463
+00:45:41,130 --> 00:45:46,370
+لأن الأنثى، احنا بحاجة عادة في كل دورة لخلية واحدة
+
+464
+00:45:46,370 --> 00:45:51,450
+بس فقط، بيضة واحدة، فهذه كلها دواهر بتصيروبعدين
+
+465
+00:45:51,450 --> 00:45:55,630
+بيصير عملية الـ Fertilization وبترجع بتكون الإنسان
+
+466
+00:45:55,630 --> 00:46:02,610
+من 2N وFertilized egg فهذه باقية الـ أو الظواهر
+
+467
+00:46:02,610 --> 00:46:09,170
+اللي بتصير في اللي بنسميه الـ Meiosis الـ Meiosis
+
+468
+00:46:09,170 --> 00:46:13,490
+اللي هو الإبتسام المنصق اللي بنتجه إنه الـ Eggs
+
+469
+00:46:13,490 --> 00:46:19,810
+والـ Sperms وبكون النتيجة إنه راح يكون عندنا 1N of
+
+470
+00:46:19,810 --> 00:46:26,700
+DNAبيكون موجود في الخلية هذه؟ في أسئلة؟ فيها دكتور
+
+471
+00:46:26,700 --> 00:46:30,540
+سؤال من دكتور معتز بخصوص عملية الـRecombination
+
+472
+00:46:30,540 --> 00:46:37,240
+نعم بيسأل هل لها تأثير؟ طبعاً لها تأثير كبير، يعني
+
+473
+00:46:37,240 --> 00:46:43,580
+في ظواهر كثيرة راح نحكي شوفوا، الأهمية اللي بنحكي
+
+474
+00:46:43,580 --> 00:46:51,270
+اللي هو حتى يفسر الواحد الأمراضوالحالات وكيف
+
+475
+00:46:51,270 --> 00:46:56,770
+الإنسان بتكون وأسباب ليش تمشي الأمور بهذا الشكل
+
+476
+00:46:56,770 --> 00:46:59,950
+يعني
+
+477
+00:46:59,950 --> 00:47:06,230
+إذا تخيلنا قضية إنه لو افترضنا إنه كل البشر
+
+478
+00:47:06,230 --> 00:47:12,490
+متشابهين تمامًا ماشي كان لو أتى أي مرض أو أي حالة
+
+479
+00:47:12,490 --> 00:47:21,110
+أو أي عدو بتلاقينا كلنا راحنتأثر بشكل شديد ولكن
+
+480
+00:47:21,110 --> 00:47:26,170
+يعني وقائة للبشرية
+
+481
+00:47:26,170 --> 00:47:29,690
+كلها ربنا حاط فينا إنه فيه اختلافات بيننا
+
+482
+00:47:29,690 --> 00:47:37,650
+والاختلافات بيظلها متكررة ومافيش تقريبًا لإثنين
+
+483
+00:47:37,650 --> 00:47:44,390
+بشر متشابهين تمامًا حتى لو يعني أقارب يعني راح
+
+484
+00:47:44,390 --> 00:47:49,000
+نحكي عن ظواهر بالتمعلى كروموزوم مش كروموزوم ثاني،
+
+485
+00:47:49,000 --> 00:47:53,600
+يعني تستنى على هذه المواضيع، أه، إلها همية كبيرة،
+
+486
+00:47:53,600 --> 00:47:59,680
+Recombination، وبتتدخل يعني في جوانب كثيرة، نعم،
+
+487
+00:47:59,680 --> 00:48:03,520
+في أسئلة أخرى؟ في سؤال من الدكتور، الدكتور
+
+488
+00:48:03,520 --> 00:48:09,060
+أويجدان، بخصوص الـPolar Body، أيش المقصود فيها؟
+
+489
+00:48:09,060 --> 00:48:16,110
+لما تسير عملية الإنقسام المنصف، ماشي،الانقسام
+
+490
+00:48:16,110 --> 00:48:24,870
+المنصف الذكر أنا بدي الأربع «Sperms» الـ «Sperms»
+
+491
+00:48:24,870 --> 00:48:32,090
+يعني الذكر بيكون عنده ملايين الحيوانات المنوية
+
+492
+00:48:32,090 --> 00:48:36,110
+وتتسابق اللي يخفي يكون أفضل واحد فيها اللي يصل
+
+493
+00:48:36,110 --> 00:48:42,310
+اللي يلقح البويضة عند الأنثة المطلوب أن تكون بويضة
+
+494
+00:48:42,310 --> 00:48:50,530
+واحدة فقطفإذا تخيلتي يعني كانت الغالية بدأت بالـ
+
+495
+00:48:50,530 --> 00:48:57,610
+Meiosis I وبتكون قبلها وصلت زي ما ذكرنا من قبل إنه
+
+496
+00:48:57,610 --> 00:49:05,090
+أعطت سوّت S phase وعملت 4N فلما تنقسم الإنقسام
+
+497
+00:49:05,090 --> 00:49:10,270
+الأول واحدة من البيتين اللي أحسن أو اللي راح تكون
+
+498
+00:49:10,270 --> 00:49:16,710
+بيضة أحسنهي اللي بتكمل والثانية يتم يعني تجميدها
+
+499
+00:49:16,710 --> 00:49:24,850
+ويتم يعني ديش أقول قضاء عليها بيظل إنه في داخل
+
+500
+00:49:24,850 --> 00:49:32,930
+تركيب الـ Boiler في المبيض الأنثى بنلاقي هيك نواة
+
+501
+00:49:32,930 --> 00:49:40,800
+يعني مضغوطة بشكل بيسموه Polar Bodyبكون هو الخلية
+
+502
+00:49:40,800 --> 00:49:46,100
+الثانية اللي يتم تخلص منها بهذا الطريق فمع
+
+503
+00:49:46,100 --> 00:49:49,860
+الإنقسام الأول، بتتم تكوين الـFirst Polar Body
+
+504
+00:49:49,860 --> 00:49:54,320
+كمية الـDNA اللي فيه بدي تكون 2N زي اللي جنبها
+
+505
+00:49:54,320 --> 00:50:01,900
+التانية لما تنقسم بالمياثيس 2 وتعطينا 1N DNA برضه
+
+506
+00:50:01,900 --> 00:50:08,340
+بتكون Polar Body ثاني، بيكون فيه 1N DNAوبكون اثنين
+
+507
+00:50:08,340 --> 00:50:12,200
+موجودات، لأنه أنا عندى انقسامين وفي حالة البويضة
+
+508
+00:50:12,200 --> 00:50:16,940
+أنا مابدى غير بويضة واحد، بس، ماشي، فعشان هيك
+
+509
+00:50:16,940 --> 00:50:25,200
+طريقتها مختلفة وهذا الـPolar Body هو تمثيل أو بقية
+
+510
+00:50:25,200 --> 00:50:33,260
+الخلية اللي كانت في الانقسام اللي لم تكمل الطريق
+
+511
+00:50:33,260 --> 00:50:37,070
+ولم يُكتب لها إنها تكمل الطريق، بحيث إنهبكون عندى
+
+512
+00:50:37,070 --> 00:50:41,050
+بوايضة واحدة يعني هي عشان ننتج بوايضة واحدة من
+
+513
+00:50:41,050 --> 00:50:48,230
+الخلية الأصلية اللى هى كانت صارت 4N بعد ما كانت 2N
+
+514
+00:50:48,230 --> 00:50:54,730
+اللى هى بداية ما يوصف، واضح؟
+
+515
+00:50:54,730 --> 00:51:06,150
+فيه أسلة؟ هيك احنا بنكون خلصنا دواهر الفصل الثانى
+
+516
+00:51:06,340 --> 00:51:12,700
+أه، في حد عنده سؤال؟ لحد الآن تمام يا دكتور أيه؟
+
+517
+00:51:12,700 --> 00:51:18,720
+نبدأ الآن بمحاضرة اليوم في سؤال من أحمد يعني يعني
+
+518
+00:51:18,720 --> 00:51:23,000
+هو سؤال ربما يعني لسه بدري عليه كيف بتصير التوائم
+
+519
+00:51:23,000 --> 00:51:29,040
+الغير متطابقة؟ أه، شوف التوائم الغير متطابقة
+
+520
+00:51:29,040 --> 00:51:38,830
+أحيانا بتنتج Boy-The-Tailيعني ويدتين بتكونوا و
+
+521
+00:51:38,830 --> 00:51:49,150
+أحياناً يعني بتتم عملية تخصيبهم بحيوانين منويين
+
+522
+00:51:49,150 --> 00:51:55,070
+اتنين أحياناً يعني الطواقم المتطابقة إنه بعد ما
+
+523
+00:51:55,070 --> 00:52:01,750
+خلية واحدة تكون ملقحة تنقسم إلى خليتين يُعاملوا
+
+524
+00:52:01,750 --> 00:52:06,580
+على إنهمبتطلب من الجسم واحد وبنقسمه لجسمين
+
+525
+00:52:06,580 --> 00:52:14,540
+وبالتالي بيصبحوا خليتين فيه دراسات حدثت بالتاريخ
+
+526
+00:52:14,540 --> 00:52:20,680
+وموجودة يعني إنه إمرأة بتطلع بوايدتين ويتم تلقيحهم
+
+527
+00:52:20,680 --> 00:52:24,880
+بحيوانات منوية من شخصين مختلفين، تخيل يعني شو صار
+
+528
+00:52:24,880 --> 00:52:29,820
+بالحالة هذه يعني، بس هاي شيء موجود في دراسة
+
+529
+00:52:29,820 --> 00:52:35,340
+الكروموزوماتالبشر والأشياء العجيبة غريبة يعني فهي
+
+530
+00:52:35,340 --> 00:52:41,160
+كلها ظواهر ممكنة وإن شاء الله سنتكلم بشكل أدق كيف
+
+531
+00:52:41,160 --> 00:52:46,030
+يتم دراسة في هذا الموضوعالآن دائماً حتى يفهم
+
+532
+00:52:46,030 --> 00:52:51,170
+الواحد شو اللي بيصير بدي أكون عنده آليات للدراسة
+
+533
+00:52:51,170 --> 00:52:56,290
+ماكروسكوبات معينة حتى أشوف شو اللي بيصير فعلى
+
+534
+00:52:56,290 --> 00:53:02,630
+استخدام الأجهزة والـ والفهم كيف يدرس هذا الموضوع
+
+535
+00:53:02,630 --> 00:53:07,710
+ممكن الواحد يعني يفهمها بشكل أفضل يعني فهي كما
+
+536
+00:53:07,710 --> 00:53:11,450
+ذكرت يعني راح ناخدها بشكل أدق يعني، ماشي؟
+
+537
+00:53:14,610 --> 00:53:20,110
+المحاضرة اليوم راح نبدأ بالـ «Human Genome والجين
+
+538
+00:53:20,110 --> 00:53:27,730
+Structure and Function» يعني نفهم كيف الـ «DNA»
+
+539
+00:53:27,730 --> 00:53:31,970
+المادة هذه اللي موجودة في النواة اللي موجودة في كل
+
+540
+00:53:31,970 --> 00:53:39,910
+الخلايا زي بعض اللي هي فيها الشيفرة الوراثية اللي
+
+541
+00:53:39,910 --> 00:53:46,130
+فيهاالمحدد لكيف مظهر الإنسان راح يكون بيعطينا
+
+542
+00:53:46,130 --> 00:53:51,990
+المظهر اللي إحنا بنشوفه بالاخير فإحنا
+
+543
+00:53:51,990 --> 00:54:04,270
+عندما نتكلم عن الإنسان كـ يعني كمخلوق أو ككائن حي
+
+544
+00:54:04,270 --> 00:54:14,250
+أو organism، ماشي لما نيجي ندرسهندرس طريقة تركيبه
+
+545
+00:54:14,250 --> 00:54:19,870
+من خلال الفهم التشريح وظائف الأعضاء والسلوكيات
+
+546
+00:54:19,870 --> 00:54:27,010
+ويعني الكيمويات تبعته والأشياء هذه لما ندرس حتى
+
+547
+00:54:27,010 --> 00:54:31,330
+تركيب هذه الترتيب
+
+548
+00:54:31,330 --> 00:54:37,630
+هذه المظاهر الكبيرة نجد أنها بالأخير يعني وحدة
+
+549
+00:54:37,630 --> 00:54:44,280
+بناء الإنسان هي من الخلايافتفاعل الخلايا وتأثر
+
+550
+00:54:44,280 --> 00:54:48,940
+الخلايا ووظيفة الخلايا وتفاعل الخلايا مع بعض هو ما
+
+551
+00:54:48,940 --> 00:54:54,980
+يعطينا المظهر الخارجي بالنهاية ففي
+
+552
+00:54:54,980 --> 00:55:00,740
+كل جوانب وظائف الخلايا تجد أنها تعتمد على
+
+553
+00:55:00,740 --> 00:55:05,380
+البروتينات في الـJacket الرئيسي أو المُركّبات
+
+554
+00:55:05,380 --> 00:55:11,310
+الموجودة فيها فالـIdea تبعت هذه الخليةالتشارك
+
+555
+00:55:11,310 --> 00:55:17,550
+الخلايا مع بعض بالتحكم ببعض والإشارة لبعض عن بعض
+
+556
+00:55:17,550 --> 00:55:22,130
+لعمل أشياء معينة تحرك الخلايا، انقسام الخلايا
+
+557
+00:55:22,130 --> 00:55:31,310
+انتصاق الخلايا ببعض حتى تكون عضو الإنفعال عند حدوث
+
+558
+00:55:31,310 --> 00:55:41,100
+مهيج خارجي وشيء خارجي كلها تعتمد علىيعني تفاعل
+
+559
+00:55:41,100 --> 00:55:49,240
+البروتينات مع بعض مع الواقع مع غيرها فالبروتينات
+
+560
+00:55:49,240 --> 00:55:52,360
+هذه اللي احنا بنشوفها ورسميها بهذا الشكل على هذا
+
+561
+00:55:52,360 --> 00:55:59,880
+المستوى تكون نتيجة إنه من الجينوم اللي هو مجمل
+
+562
+00:55:59,880 --> 00:56:07,160
+المادة الوراثية الـDNA كله يكون هناك قطع تسمى
+
+563
+00:56:07,160 --> 00:56:14,620
+جيناتماشي، كل جين بتتم عملية راح نحكي عملية الـ
+
+564
+00:56:14,620 --> 00:56:20,560
+Transcription ليعطينا الـ RNA اللي هو الـ
+
+565
+00:56:20,560 --> 00:56:25,900
+Messenger RNA طبعاً بالأول بيكون Primary RNA ممكن
+
+566
+00:56:25,900 --> 00:56:32,960
+مايكونش الـ Messenger أول ما يطلع وبتكون يعني RNA
+
+567
+00:56:32,960 --> 00:56:37,540
+يمكن هنا الـ Nascentأو Early أو الـPrimary RNA
+
+568
+00:56:37,540 --> 00:56:40,980
+بنسميه مثلا أحياناً فـHealth بيعطينا بعدين
+
+569
+00:56:40,980 --> 00:56:45,260
+بالـTranslation عملية إنه يعطينا البروتين البروتين
+
+570
+00:56:45,260 --> 00:56:50,600
+هذا هو اللي بيقدّي الوظيفة من خلال الـCell
+
+571
+00:56:50,600 --> 00:56:56,460
+Function اللي بيعطينا تكوين الـOrgans اللي بيعطينا
+
+572
+00:56:56,460 --> 00:57:02,320
+بعدين كل الـOrganism فيعني
+
+573
+00:57:02,320 --> 00:57:10,450
+الأخيركثير من الخواص والظواهر والـ «فاصيلة الدم»
+
+574
+00:57:10,450 --> 00:57:15,530
+ولون الشعر وقوة العضلات ووظيفة الإنسولين ووظيفة
+
+575
+00:57:15,530 --> 00:57:21,070
+المناعة ووظيفة كذا وذكاء هذا الإنسان وقدراته
+
+576
+00:57:21,070 --> 00:57:26,870
+العقلية وردود فعله كيف وكذا كلها بالأخير ترجع إلى
+
+577
+00:57:26,870 --> 00:57:33,330
+التفاعل الدرجة الأساسية للـGenomeمع ممكن الـ
+
+578
+00:57:33,330 --> 00:57:37,770
+Environment في جانب ثاني بحيث إنه بعطينا الـ Gene
+
+579
+00:57:37,770 --> 00:57:41,270
+Products اللي هم البروتينات اللي أنا بشوفها اللي
+
+580
+00:57:41,270 --> 00:57:45,470
+بالأخير بتعطيني خواص هذا الإنسان وميزته طبعا
+
+581
+00:57:45,470 --> 00:57:52,130
+الإنسان يعني إلا يكون البيئة إلها دور في قضية
+
+582
+00:57:52,130 --> 00:57:58,250
+مظهريته وقبراته السابقة وما اتعرض لهمن إشعاع
+
+583
+00:57:58,250 --> 00:58:04,570
+وكيمويات وغذاء واحتياجات وميكروبات وغيرها كلها
+
+584
+00:58:04,570 --> 00:58:12,510
+بتعطينا خاصية الواحد منها فهي أهمية فهم الجينوم
+
+585
+00:58:12,510 --> 00:58:24,050
+وفهم الجينات اللي فيه لما ندرس هذا الموضوع
+
+586
+00:58:25,370 --> 00:58:31,270
+فهنا مثلًا مثال، أنا كان صراحة عندي هيك بوستر كبير
+
+587
+00:58:31,270 --> 00:58:38,110
+حوالي يعني متر ونصف متر، يعني إشي كبير حاطين
+
+588
+00:58:38,110 --> 00:58:44,850
+الـ44، الـ46 كروموزوم أو الـ32، الـ23 كروموزوم على
+
+589
+00:58:44,850 --> 00:58:52,430
+أساس المعدل الـX والـY وحاطين كل واحد القطع تبعينه
+
+590
+00:58:53,340 --> 00:59:01,660
+الـ… الـ… الـChromosome لما نشوفه الـP القطعة
+
+591
+00:59:01,660 --> 00:59:07,680
+الصغيرة الـQ القطعة الطويلة هذه فبنسميها وبعدين
+
+592
+00:59:07,680 --> 00:59:13,820
+أنا ممكن أدرس يعني فيه من خلال تقنية الـPCR
+
+593
+00:59:13,820 --> 00:59:16,220
+Polymerase Chain Reaction اللي هي عملية
+
+594
+00:59:16,220 --> 00:59:21,570
+الـSequencing اللي هي أنه أنا أدرس الـ…الـ DNA
+
+595
+00:59:21,570 --> 00:59:26,250
+وأنا كنت ذكرت معلومة بالذات للـ DNA تبع البشر إنه
+
+596
+00:59:26,250 --> 00:59:32,610
+حوالي 95% منه لا قيمة له عبارة عن repeats وواضح
+
+597
+00:59:32,610 --> 00:59:37,050
+لما تيجي تقرأ كأنه يعني إذا اعتبرت أحرف
+
+598
+00:59:39,650 --> 00:59:45,370
+مثلًا، يعني نفترض إنه هذا الـGene هو قصيدة معينة
+
+599
+00:59:45,370 --> 00:59:53,870
+مثلًا، ولد ال .. يعني في مزح الرسول ﷺ أو طلع البدر
+
+600
+00:59:53,870 --> 00:59:59,010
+علينا، نفترض هيك، فبتلاقي قطعة كبيرة مثلًا، نفترض
+
+601
+00:59:59,010 --> 01:00:03,850
+بالأحرف مثلًا، ألف، ألف، ألف، ألف، ألف، ألف، ألف،
+
+602
+01:00:03,850 --> 01:00:07,010
+ألف، ألف، ألف، ألف، ألف، ألف، ألف، ألف، ألف، ألف،
+
+603
+01:00:19,540 --> 01:00:20,940
+عالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعال
+
+604
+01:00:26,570 --> 01:00:31,170
+حكينا الـ Centromere اللي هو حكيناه هنا اللي
+
+605
+01:00:31,170 --> 01:00:38,010
+استفاد منه في عملية فصل الـ Myosis والـ Metaphase
+
+606
+01:00:38,010 --> 01:00:41,290
+وهذه
+
+607
+01:00:41,290 --> 01:00:45,130
+بتكون عملية الـ Bands لما أنا أجي أدرس الـ Band
+
+608
+01:00:45,130 --> 01:00:52,410
+هذه بلاقي إن أنا كل ما أدرس بشكل أدق بلاقي الجينات
+
+609
+01:00:52,410 --> 01:01:00,160
+موجودة بشكل مراتمناطق ما لهاش قيمة ومناطق غنية
+
+610
+01:01:00,160 --> 01:01:04,900
+بالجينات اللي هي بتأثر فمثلًا على الـ Chromosome
+
+611
+01:01:04,900 --> 01:01:15,340
+11 اللي هو 135 ميجا يعني اللي هو تقريبًا مليون
+
+612
+01:01:15,340 --> 01:01:21,520
+Base of DNA فلمّا
+
+613
+01:01:21,520 --> 01:01:27,990
+تيجي على الـ يعنيهذه القطع بعدين بيسموها في One
+
+614
+01:01:27,990 --> 01:01:35,190
+وTwo وThree وFour بيصير يسميهم ويعني هذه تعتبروها
+
+615
+01:01:35,190 --> 01:01:40,110
+زي إشارات على الطريق يعني أو تقسيمات أو شوارع أو
+
+616
+01:01:40,110 --> 01:01:47,150
+بلوكات أو يعني حتى يكون نوع من العنوان لإشي لما
+
+617
+01:01:47,150 --> 01:01:53,110
+نيجي ندرسه ففي الموقع الفلاني بنلاقي فيهاللي هو
+
+618
+01:01:53,110 --> 01:01:58,250
+مثلًا هنا Olfactory Receptor Gene يعني اللي هي
+
+619
+01:01:58,250 --> 01:02:06,290
+الجينات المسؤولة على مستقبلات حصة الشم فلما نيجي
+
+620
+01:02:06,290 --> 01:02:11,570
+نأخذها بشكل أدق بنلاقي مثلًا هنا Beta Chain، Delta
+
+621
+01:02:11,570 --> 01:02:18,570
+Chain، A, Gamma، G, Gamma، Epsilon، I، بتكون
+
+622
+01:02:18,570 --> 01:02:25,820
+موجودةودايمًا إحنا يعني كقاعدة لما نتكلم على
+
+623
+01:02:25,820 --> 01:02:31,040
+الـDNA إنه الـTranscription Direction اللي هو من
+
+624
+01:02:31,040 --> 01:02:36,100
+الخمس إلى الثلاث يعني هذه ترتيبها اللي تم عملية
+
+625
+01:02:36,100 --> 01:02:43,740
+الـTranscription تبعتها فهنا يعني نوع من التعقيد
+
+626
+01:02:43,740 --> 01:02:51,830
+بحيث إنه يعني شو أنا بحاجة إنهحتى أفهم من اللي هو
+
+627
+01:02:51,830 --> 01:02:56,050
+القطعة الكبيرة اللي فيها آلاف الكرموزومات آلاف
+
+628
+01:02:56,050 --> 01:03:06,330
+الجينات كواحد من الـ46 كرموزوم للجينوم بنزل الواحد
+
+629
+01:03:06,330 --> 01:03:18,980
+لمستوى إنه يشوف الجينات فيه واضح، فيها سلة،على هذا
+
+630
+01:03:18,980 --> 01:03:23,760
+الـ «سلايف»؟
+
+631
+01:03:23,760 --> 01:03:30,140
+طيب حكينا
+
+632
+01:03:30,140 --> 01:03:33,740
+نرجع
+
+633
+01:03:33,740 --> 01:03:45,160
+مرة ثانية الـ «DNA» في الـ «ريبوز» هذا للـ «RNA»
+
+634
+01:03:45,160 --> 01:03:53,720
+الـ «DNA» ديوكسي ريبوزفبكون في عندى Phosphate فالـ
+
+635
+01:03:53,720 --> 01:03:59,780
+الـ الـ الـ طرفي السلم اللولبي من الـ
+
+636
+01:03:59,780 --> 01:04:04,000
+Phosphatribose Phosphatribose Phosphatribose هدولة
+
+637
+01:04:04,000 --> 01:04:09,620
+الطرفين الدرج أو المصطبى اللي بتحط إجرك عليها في
+
+638
+01:04:09,620 --> 01:04:15,340
+السلم بتكون من Two Bases بكون شبكين الـ Base
+
+639
+01:04:15,340 --> 01:04:19,760
+Nitrogenous Base بتكون ماسكة بهذا الشكلفعندي
+
+640
+01:04:19,760 --> 01:04:26,540
+Purines وPrimidines وفي حالة الـ RNA فيه اختلافين
+
+641
+01:04:26,540 --> 01:04:33,880
+ثانيات الـ RNA فيه بدل الـ Deoxyribose فيه الـ
+
+642
+01:04:33,880 --> 01:04:45,340
+Ribose يعني بنقص منه ذرة Oxygen وبدل الـ T فيه U
+
+643
+01:04:45,340 --> 01:04:52,230
+الـ Uracineففيه اختلافين بالنسبة لشكل الـ… الـRNA
+
+644
+01:04:52,230 --> 01:04:57,710
+عن الـDNA هنا
+
+645
+01:04:57,710 --> 01:05:02,730
+يعني برضه تفصيل
+
+646
+01:05:02,730 --> 01:05:09,970
+لأنواع مختلفة من التركيب الـDNA على مستوى الـGene،
+
+647
+01:05:09,970 --> 01:05:18,310
+ماشي؟ الـGene هي قطع من الـDNA يتمعملية الـ
+
+648
+01:05:18,310 --> 01:05:24,250
+Transcription تبعتها إلى RNA وبالتالي بعد ذلك إلى
+
+649
+01:05:24,250 --> 01:05:32,850
+البروتين يعني هذه اللي بدنا نفهمها إحنا الآن نتكلم
+
+650
+01:05:32,850 --> 01:05:44,370
+على مستوى الـ DNA أي قطعة حتى يتم عملية نقلها،
+
+651
+01:05:44,370 --> 01:05:48,890
+اللي هي Transcriptionلأرى إنها حتى تتحول لـ
+
+652
+01:05:48,890 --> 01:05:56,790
+Protein بكون الـ الـ الـ الـ DNA تبعها في مكان
+
+653
+01:05:56,790 --> 01:06:05,710
+محدد بكون بشكل محدد وبكون يعني إله مجموعات من الـ
+
+654
+01:06:05,710 --> 01:06:10,850
+يعني من القطع حتى
+
+655
+01:06:10,850 --> 01:06:16,010
+يعني هنا بشكل افتراضيالـ Beta-Globulin تبع الـ
+
+656
+01:06:16,010 --> 01:06:22,330
+«هيموجلوبين» الـ «براكا» راح ناخد عنها وهي يعني
+
+657
+01:06:22,330 --> 01:06:25,410
+عبارة عن بروتين اللي له أهمية في انقسام القلايا
+
+658
+01:06:25,410 --> 01:06:30,350
+فهو مربوط وموجود في أنواع من السرطانات ولا
+
+659
+01:06:30,350 --> 01:06:34,410
+احتمالية يعني وجدوا وجود اختلالات في هذا الجين
+
+660
+01:06:34,410 --> 01:06:40,360
+بسبب أنه أنواع من السرطانات بتحدثوبروتين آخر أو
+
+661
+01:06:40,360 --> 01:06:46,580
+جين آخر مسؤول عن تكون العضلات في القلب فبيسوي
+
+662
+01:06:46,580 --> 01:06:50,160
+hypertrophic obstructive cardiomyopathy أو
+
+663
+01:06:50,160 --> 01:06:56,540
+كارديومايوباتي بيسوي ضعف عضلة القلب فالجينات هذه
+
+664
+01:06:56,540 --> 01:07:01,200
+على مستوى الـ DNA كل
+
+665
+01:07:01,200 --> 01:07:05,200
+واحد منهم هنا حاطين راح يصير بعدين إحنا شو ناخد
+
+666
+01:07:05,200 --> 01:07:14,220
+ككس؟عن مرض إله دخل بهذه الحالة فالـ الـ الـ الـ
+
+667
+01:07:14,220 --> 01:07:17,560
+لما ناخد إحنا الـ DNA راح نشوف الأشياء بهذه
+
+668
+01:07:17,560 --> 01:07:27,600
+الطريقة أي Gen يتم بعدين نسخه حتى يتم التعرف على
+
+669
+01:07:27,600 --> 01:07:31,780
+إن هذا هو الـ Gen وإنه احنا من هنا لازم نبدأ ننسخ
+
+670
+01:07:31,780 --> 01:07:38,580
+وبعدين كيف بدخل الأمور مع بعضباللاقي أنه يعني بعد
+
+671
+01:07:38,580 --> 01:07:45,040
+طبعاً أنا في الـ الـ الـ الـ strand أو في الجهة
+
+672
+01:07:45,040 --> 01:07:48,760
+اللي راح أنسخها من الـ five prime ل three prime
+
+673
+01:07:48,760 --> 01:07:53,480
+يعني هاي ده يعني قاعد نعتمد عليها و هيك بيعتبروها
+
+674
+01:07:53,480 --> 01:08:00,030
+أنه بالأول في promoted region يعنيفيه لازم يكون في
+
+675
+01:08:00,030 --> 01:08:05,850
+سلسلة الأحرف هذه فيه شيء معين أو قطعة معينة أو
+
+676
+01:08:05,850 --> 01:08:12,550
+ترتيب معين يكون يعني يساعدنا ويساعد عملية الـ
+
+677
+01:08:12,550 --> 01:08:17,150
+Transcription أنه تبدأ من هذا المكان حتى يطلع عندي
+
+678
+01:08:17,150 --> 01:08:21,170
+الـ Protein اللازم أو الـ RNA اللازم اللي بحتاجه
+
+679
+01:08:21,170 --> 01:08:28,230
+ففي عندي الـ Start of Transcription يعنيهنا في شيء
+
+680
+01:08:28,230 --> 01:08:33,390
+لما نبدأ عملية الـ Transcription بتروح، بتدور على
+
+681
+01:08:33,390 --> 01:08:40,870
+هذه قطعة حتى إنها تبدأ من هنا يعني إذا الواحد باخد
+
+682
+01:08:40,870 --> 01:08:44,090
+شوه عملية الـ Transcription، Translation يعني مشبه
+
+683
+01:08:44,090 --> 01:08:49,850
+الواحد بسحاب البنطلون أو سحاب الجاكيت أو الشيء
+
+684
+01:08:49,850 --> 01:08:54,950
+يعني فبدنا إشي بالأول انميز إنه أنا بدي أبدأ حتى
+
+685
+01:08:55,450 --> 01:08:58,970
+يغطبت هذا مع هذا بشكل جيد،
+إنه أنا بدي أبدأ من هذا
+
+686
+01:08:58,970 --> 01:09:04,350
+المكان بالنسبة للجينات ليس بالضرورة أن يكون الـ
+
+687
+01:09:04,350 --> 01:09:12,470
+Protein ناتج عن قطعة متصلة من الـ DNA أحيانًا أكثر
+
+688
+01:09:12,470 --> 01:09:19,150
+من قطعة بتتم استخدامها وبالتالي، لما نتكوّن على أي
+
+689
+01:09:19,150 --> 01:09:25,890
+بيتكلم على أي Protein هنا مثلًاهناك ما يسمى الـ
+
+690
+01:09:25,890 --> 01:09:31,050
+Exon والـ Intron الـ Intron هي القطع الـ
+
+691
+01:09:31,050 --> 01:09:34,430
+intervening sequences اللي لن يتم الاستفادة منها
+
+692
+01:09:34,430 --> 01:09:39,330
+وبالتالي يعني لما أنا بدي أكول البروتين الحقيقي
+
+693
+01:09:39,330 --> 01:09:44,190
+على مستوى الـ DNA بيكون بهذا الشكل فارط شويه زيادة
+
+694
+01:09:44,190 --> 01:09:51,790
+يعني متساق وهناك قطع من المنتصف لا يتم الاستفادة
+
+695
+01:09:51,790 --> 01:09:56,510
+منهاأحيانًا، يعني زي هذا البروتين الـIntrons
+
+696
+01:09:56,510 --> 01:10:00,890
+والـExons والـExons تبعينه تتساعر، يعني بهذا الشكل
+
+697
+01:10:00,890 --> 01:10:08,110
+ففي هذه المثال الـCodon،
+
+698
+01:10:08,110 --> 01:10:12,630
+الـInitiator الـCodon، راح نحكي عنه بعد شوية اللي
+
+699
+01:10:12,630 --> 01:10:16,950
+راح يبدأ العملية الـTranscription وراح يكون هذا
+
+700
+01:10:16,950 --> 01:10:21,450
+بدنا ناخده، هذا راح نقصه وما بدنا نشيهبناخد هذا
+
+701
+01:10:21,450 --> 01:10:24,290
+القطعة، وبعدين بنقص هذا الجزء وبعدين بناخد هذا
+
+702
+01:10:24,290 --> 01:10:28,050
+الجزء وبعدين بنقص هذا الجزء بهذه الطريقة لحد ما
+
+703
+01:10:28,050 --> 01:10:34,510
+أنهي المطلوب منه فهذه الظاهرة بتتم أنه على مستوى
+
+704
+01:10:34,510 --> 01:10:41,510
+الـDNA ما يتم يعني أحياناً بتكون هذه الظاهرة على
+
+705
+01:10:41,510 --> 01:10:47,400
+مثل مستوى الـRNA وبعدين اللي هي القص واللصب فيهابس
+
+706
+01:10:47,400 --> 01:10:54,160
+لازم يكون بالأول شيء يظهر للقالية عملية الـ
+
+707
+01:10:54,160 --> 01:10:58,500
+Transcription إنه ابدا من هذه النقطة Initiator
+
+708
+01:10:58,500 --> 01:11:03,680
+Codon و Termination Codon لوقف عملية نسخ تبع الـ
+
+709
+01:11:03,680 --> 01:11:11,220
+DNA لمسينجر RNA أو للـ RNA ولأنواع مختلفة بتلاقي
+
+710
+01:11:11,220 --> 01:11:16,810
+على كرموزومات مختلفة بتلاقي الجينات بهذا الشكلبكون
+
+711
+01:11:16,810 --> 01:11:21,410
+أنا بقرأ أشياء ما لهاش قيمة، ما لهاش معنى كتير،
+
+712
+01:11:21,410 --> 01:11:29,470
+وبعدين بدخل في مناطق بلاقي فيها مادة مفيدة لـ…
+
+713
+01:11:29,470 --> 01:11:34,670
+كجينها، فكان زمان يقدروا يمكن فيه خمسين لـ100 ألف
+
+714
+01:11:34,670 --> 01:11:38,990
+جين، بس لما عملوا الـHuman Genome وقروا
+
+715
+01:11:38,990 --> 01:11:42,390
+الـNucleotides واحد ورا الثاني، واحد ورا الثاني،
+
+716
+01:11:42,390 --> 01:11:45,860
+واحد ورا الثاني،لقينا، اللي هي الرقم اللي بيقدروا
+
+717
+01:11:45,860 --> 01:11:54,100
+الآن من 22 ألف لـ25 ألف Gen من خلال اللي هي إنه
+
+718
+01:11:54,100 --> 01:12:01,260
+واضح إنه هذه منطقة فيها شيء راح ينقره، أيوة، إيه
+
+719
+01:12:01,260 --> 01:12:05,900
+ناس؟ تفضلي، ليش
+
+720
+01:12:05,900 --> 01:12:06,520
+السؤال؟
+
+721
+01:12:12,050 --> 01:12:17,970
+دكتور أحمد، في سؤال إن شاء الله الأمور واضحة، أجل
+
+722
+01:12:17,970 --> 01:12:31,670
+فضلها دكتور أيناس، إذا عندك سؤال يبدو
+
+723
+01:12:31,670 --> 01:12:38,650
+أن هناك سؤال فإن شاء الله الأمور واضحة الآن، يعني
+
+724
+01:12:38,650 --> 01:12:42,810
+هذه نرجع مرة ثانيةلما واحد يتعامل مع الـ DNA
+
+725
+01:12:42,810 --> 01:12:47,550
+والوراثة بهذا الشكل مصطلح، Transcription،
+
+726
+01:12:47,550 --> 01:12:53,050
+Translation، Protein Assembly وصف الخطوات هذه، يجب
+
+727
+01:12:53,050 --> 01:13:00,290
+أن يكون الواحد فاهم حكينا
+
+728
+01:13:00,290 --> 01:13:05,230
+الـ DNA اللي هو الـ Double Helix اللي يتم قراءته
+
+729
+01:13:05,230 --> 01:13:14,800
+هو اللي من خمس لثلاثةماشي، فبتم
+
+730
+01:13:14,800 --> 01:13:20,500
+دايماً قراءة واحد من الـ Double Helix ما يتم قراءة
+
+731
+01:13:20,500 --> 01:13:27,240
+اتنين، بتكون من جهة واحدة، بكون من خمسة لثلاثة الـ
+
+732
+01:13:27,240 --> 01:13:35,740
+Transcription بنتج عنها اللي هو الـ يعني يسمونه
+
+733
+01:13:35,740 --> 01:13:43,400
+الـ nascent أو الـ الـ RNA الأوليماشي، وبكون عندي
+
+734
+01:13:43,400 --> 01:13:47,180
+فيه بالأول اللي هو «Start-up Codon» وفيه
+
+735
+01:13:47,180 --> 01:13:51,220
+«Termination Codon» حتى نعرف إنه أنا بحاجة إن أعمل
+
+736
+01:13:51,220 --> 01:13:55,660
+Transcription للقطعة هذه وأكملها، بيبدأ النظام زي
+
+737
+01:13:55,660 --> 01:14:00,360
+سحاب يمسك واحد واحد كل واحد من الـNucleotides
+
+738
+01:14:00,360 --> 01:14:05,000
+يقراها شو هي ويعطينا المكافئة تبعها حسب قليل
+
+739
+01:14:05,000 --> 01:14:10,020
+التصاق أو التكافؤبحيث إنه بنبدأ من هون وبتكون هي
+
+740
+01:14:10,020 --> 01:14:14,140
+ظاهرة لأنه أنا احتجت إني أنسخ هذا الـDNA في هذه
+
+741
+01:14:14,140 --> 01:14:18,760
+القطعة فتبدأ من هنا وبتظل أتكمل لحد ما تشوف أشي
+
+742
+01:14:18,760 --> 01:14:24,900
+كله وقف فلما انتصل هنا بوقف فهذا طلع إني اللي هو
+
+743
+01:14:24,900 --> 01:14:31,540
+الـPrimary RNA الـPrimary RNA في الـExons اللي هم
+
+744
+01:14:31,540 --> 01:14:35,380
+هذولة اللي تم الاستفادة منهم وفي إيش اسمه
+
+745
+01:14:35,380 --> 01:14:42,830
+الـIntron اللي بالنصرالـ Intron بتتم قصهم ولصق الـ
+
+746
+01:14:42,830 --> 01:14:51,630
+Messenger RNA بشكل متلاصق كامل بحيث أنه بنسميها
+
+747
+01:14:51,630 --> 01:14:56,230
+The Alternative أو RNA Processing أو Alternative
+
+748
+01:14:56,230 --> 01:15:00,950
+Splicing بتسموه مرات يعني قص و لصق على مستوى الـ
+
+749
+01:15:00,950 --> 01:15:08,920
+RNA بحيث أنه القطع المطلوبة تميعني لصقة بشكل
+
+750
+01:15:08,920 --> 01:15:15,660
+متلاصق بحيث يعطينا الـMessenger RNA المرحلة الأولى
+
+751
+01:15:15,660 --> 01:15:19,940
+بتكون في الـNucleus هنا المفروض يرسموننا
+
+752
+01:15:19,940 --> 01:15:25,500
+الـNuclear Membrane، P-Pores المسنجر RNA اللي هو
+
+753
+01:15:25,500 --> 01:15:32,580
+الكامل بتطلع لبرا فبروح جوا الـCytoplasm، بروح
+
+754
+01:15:32,580 --> 01:15:37,970
+بالذات على الـGolgi Apparatusبتم عملية بالذات الـ
+
+755
+01:15:37,970 --> 01:15:40,810
+Protein synthesis عند الـ Rough endoplasmic
+
+756
+01:15:40,810 --> 01:15:46,030
+reticulum اللي هي من تراكيب الخلية وفيها بتم عملية
+
+757
+01:15:46,030 --> 01:15:50,410
+بناء الـ Protein بناء الـ Protein إنه بيجي إشي
+
+758
+01:15:50,410 --> 01:15:58,970
+اسمه Ribosome زي الزبر تبع السحاب بيبدأ يشبك على
+
+759
+01:15:58,970 --> 01:16:04,050
+Messenger RNA ويكون هنا فيه، بيسموه Ribosome
+
+760
+01:16:04,050 --> 01:16:07,920
+الـRNAهذا الـ Messenger RNA وبعدين بيجي الـ
+
+761
+01:16:07,920 --> 01:16:13,840
+Ribosome الـ RNA الـ Ribosome الـ RNA بطريقة معينة
+
+762
+01:16:13,840 --> 01:16:20,340
+بيكون فيه الـ Transfer of RNA بشبك عليه الـ Amino
+
+763
+01:16:20,340 --> 01:16:30,340
+Acid فالـ… مع سير الـ Ribosome على الـ Messenger
+
+764
+01:16:30,340 --> 01:16:36,460
+RNA الـالـ Polypeptide Chain اللي هي الـ «أمانو
+
+765
+01:16:36,460 --> 01:16:41,080
+أسد» تتشبك وراء بعض، one after another بيصير تشبك
+
+766
+01:16:41,080 --> 01:16:44,600
+وراء بعض وبالتالي كل ما يقرأ أكتر بيعطينا حجم
+
+767
+01:16:44,600 --> 01:16:50,040
+البروتين أكبر بحيث إنه بالأخير بنتج عندي البروتين
+
+768
+01:16:50,040 --> 01:16:55,100
+وبعدين بسوي البروتين الـAssembly بهذا الشكل فهذه
+
+769
+01:16:55,100 --> 01:17:01,460
+الظواهر بتتم يعني إحنا هنا بنصف بالشكل أدق وتفصيلي
+
+770
+01:17:02,230 --> 01:17:09,490
+مجمل الظواهر في كيفية تحويل المعلومات والشفرة اللي
+
+771
+01:17:09,490 --> 01:17:13,470
+موجودة في الـ DNA بحيث إنه بالأخير تعطيني الـ
+
+772
+01:17:13,470 --> 01:17:18,230
+Protein أنا بحتاجه أو تحتاجه هذه الخلية بحيث إنه
+
+773
+01:17:18,230 --> 01:17:23,310
+راح يكون بالأول عملية unfolding of the DNA وبعدين
+
+774
+01:17:23,310 --> 01:17:27,810
+for the transcribed strand عملية الـ Transcription
+
+775
+01:17:28,640 --> 01:17:33,420
+وفيه اللي هي Starton وفيه End وفيه Poly-A-Addition
+
+776
+01:17:33,420 --> 01:17:38,500
+بالأخير حتى يكون نهاية وبعدين بيصير عملية تنظيف
+
+777
+01:17:38,500 --> 01:17:42,660
+للـRNA على مستوى الـRNA حيث إنه بيعطينا
+
+778
+01:17:42,660 --> 01:17:46,240
+الـMessenger RNA بيطلع في الـ… سواء Rough end
+
+779
+01:17:46,240 --> 01:17:49,640
+-plasmic reticulum نسميها Rough end-plasmic
+
+780
+01:17:49,640 --> 01:17:52,920
+reticulum لأنها بيكون فيها، لما واحد يشوف
+
+781
+01:17:52,920 --> 01:17:58,920
+الـRibosomes هذه بيشوفها، بيخلي المظهر مش Smoothمش
+
+782
+01:17:58,920 --> 01:18:07,840
+هيك يعني مجعلق يعني فبتصير عملية الـ Translation
+
+783
+01:18:07,840 --> 01:18:14,880
+اللي بتعطيني الـ Protein Assembly فهي الظواهر اللي
+
+784
+01:18:14,880 --> 01:18:18,260
+بتتم وهي كلها علوم يعني أنتوا أخدتوها الأصل
+
+785
+01:18:18,260 --> 01:18:23,160
+بالثانوية العامة أو بالمدارس وشغلات يعني مشهورة بس
+
+786
+01:18:23,160 --> 01:18:28,090
+الواحد يكون فاهم عنهادكتور، في سؤال من أحمد بخصوص
+
+787
+01:18:28,090 --> 01:18:32,530
+القضية اللي هو اتجاه عملية الـ Transcription تكون
+
+788
+01:18:32,530 --> 01:18:37,870
+من المبين في الصورة فعلاً من الـ3' إلى الـ5' هو
+
+789
+01:18:37,870 --> 01:18:41,310
+عملية اللي هو الـ Transcription على الـDNA لكن
+
+790
+01:18:41,310 --> 01:18:45,150
+عملية الـ Translation صارت من الـ5' إلى الـ3'
+
+791
+01:18:45,490 --> 01:18:51,390
+للـRNA، فهو بيسأل … بالله أنا اللي بقرا أنه الـ
+
+792
+01:18:51,390 --> 01:18:55,040
+Transcription Direction من 5 إلى 3بس انبهر في
+
+793
+01:18:55,040 --> 01:18:57,200
+الصورة أنه هو الـ «تجارب» – اللي بيكون غلط في
+
+794
+01:18:57,200 --> 01:19:02,740
+الرسم أحياناً ممكن تلاقي الرسمات غلط، فدايماً يعني
+
+795
+01:19:02,740 --> 01:19:05,460
+سواء في الـtranscription أو بتوقع حتى في
+
+796
+01:19:05,460 --> 01:19:11,000
+الـreplication الأليات إنك أنت بتبدأ من الـ يعني
+
+797
+01:19:11,000 --> 01:19:15,220
+الـ strand that is transcribed بيكون من الخمس
+
+798
+01:19:15,220 --> 01:19:22,860
+لثلاث، هيك بفهميعني هنا خمسة «برايم» لثلاثة
+
+799
+01:19:22,860 --> 01:19:27,800
+«برايم»، هيك بالفعل، ماشي فالـ «ستراند» الموجود
+
+800
+01:19:27,800 --> 01:19:32,200
+هنا اللي تم يعني النسخ منه من الـ الـ الـ اللي هو
+
+801
+01:19:32,200 --> 01:19:35,820
+الـ «DNA» كان الـ «ستراند» اتجاه النسخ عليه من
+
+802
+01:19:35,820 --> 01:19:40,440
+تلاتة «برايم» لخمسة «برايم» يعني هي شوية confusing
+
+803
+01:19:40,440 --> 01:19:47,680
+هناأنا يعني خلّيني يعني أقولك اللي كل ال .. أو
+
+804
+01:19:47,680 --> 01:19:51,640
+يعني كثير من المرة بيكتبوها يعني إنه في
+
+805
+01:19:51,640 --> 01:19:56,140
+الـReference Strand وفي الـكيف نتكلم مع الـStrand
+
+806
+01:19:56,140 --> 01:20:01,300
+وكيف بدنا نرتقل يعني لما شوفت الصورة اللي اختلفنا
+
+807
+01:20:01,300 --> 01:20:05,660
+عليها شوية في الخمس أشخاص اللي كنا عنها Reference
+
+808
+01:20:05,660 --> 01:20:11,060
+Strand وكدهإنه دايماً نمشي من الـ5' إلى الـ3'،
+
+809
+01:20:11,060 --> 01:20:14,160
+يعني هي كمية. هو المقصود، على حسب ما أذكر أنا
+
+810
+01:20:14,160 --> 01:20:19,260
+برضه، المقصود إنه إنشاء نسخة من الـDNA اللي هو
+
+811
+01:20:19,260 --> 01:20:23,960
+أساساً non-transcribed strand، يعني الهدف إنه أنا
+
+812
+01:20:23,960 --> 01:20:27,260
+أخد نسخة من الـnon-transcribed strand اللي هو من
+
+813
+01:20:27,260 --> 01:20:31,720
+5' إلى 3'. فأنا عشان هيك بنسخ من الـstrand
+
+814
+01:20:31,720 --> 01:20:37,580
+المقابل، اللي هو من 3' إلى 5'.شوف هاي معلومة دقيقة
+
+815
+01:20:37,580 --> 01:20:42,500
+كثير كثير كثير يمكن مالهاش فايد كثير، بس بشكل عام
+
+816
+01:20:42,500 --> 01:20:50,080
+لما نحكي عن ترتيب الـNucleotides ومواقعها، يعني
+
+817
+01:20:50,080 --> 01:20:56,900
+أنت أسا لما تأخذ بعدين، راح نتكلم على تسمي طفرة
+
+818
+01:20:56,900 --> 01:21:02,380
+معينة، فهيقولّك جي مثلا اللي هو يعني الـAmino Acid
+
+819
+01:21:02,380 --> 01:21:03,320
+الأولاني
+
+820
+01:21:05,620 --> 01:21:11,920
+بديل برقم 100 بعدين C مثلًا نفترض بهذا الشكل المية
+
+821
+01:21:11,920 --> 01:21:18,060
+هذه اللي بدك تأخذها إنه أنت بتقرأ القطعة من الـ
+
+822
+01:21:18,060 --> 01:21:22,280
+DNA و لا ال transcription و لا الـ كذا، راح تقراها
+
+823
+01:21:22,280 --> 01:21:26,340
+من الخمس إلى التلاتة، بدك تأخذها بهذا الشكل، فاهم
+
+824
+01:21:26,340 --> 01:21:31,650
+عليك كيف؟فهذه الصورة هي عملية النسخ، إنه أنا لما
+
+825
+01:21:31,650 --> 01:21:37,870
+أنسخ الـStrand اللي هو بيكون مقابل للـStrand
+
+826
+01:21:37,870 --> 01:21:41,190
+الأصلي أو خلّيني نسميه الـStrand اللي أنا بدي منه
+
+827
+01:21:41,190 --> 01:21:46,570
+نسخة هم اتنين، اسمعلي، اسمعلي، حسنا، انت لما يكون
+
+828
+01:21:46,570 --> 01:21:53,570
+عندك السلة من لولا بيه مع بعض، ماشي، تمام، تفصلوا،
+
+829
+01:21:53,570 --> 01:21:59,430
+صح؟إذا بدّي أعمل DNA replication، شو راح أسوي؟
+
+830
+01:21:59,430 --> 01:22:04,470
+الجهتين، كل واحد، راح أحط المقابل له «طبعًا»
+
+831
+01:22:04,470 --> 01:22:06,250
+«طبعًا» «طبعًا» «طبعًا» «طبعًا» «طبعًا» «طبعًا»
+
+832
+01:22:06,250 --> 01:22:06,710
+«طبعًا» «طبعًا» «طبعًا» «طبعًا» «طبعًا» «طبعًا»
+
+833
+01:22:06,710 --> 01:22:07,430
+«طبعًا» «طبعًا» «طبعًا» «طبعًا» «طبعًا» «طبعًا»
+
+834
+01:22:07,430 --> 01:22:12,550
+«طبعًا» «طبعًا» «طبعًا» «طبعًا» «طبعًا» «طبعًا»
+
+835
+01:22:12,550 --> 01:22:21,110
+«طبعًا» «طبع
+
+836
+01:22:22,650 --> 01:22:27,160
+واللي بيفرضوه لعملية الـ Transcriptionإن أنا باخد
+
+837
+01:22:27,160 --> 01:22:30,140
+من خمس إلى ثلاثة، هذا اللي بد يكون اللي بد أشتغل
+
+838
+01:22:30,140 --> 01:22:34,600
+عليه، أنا هيك بفهمه، بدي أتعامل …المقصد ده يا
+
+839
+01:22:34,600 --> 01:22:37,900
+دكتور يعني، والمقصد يعني، عشان يكون من خمس إلى
+
+840
+01:22:37,900 --> 01:22:43,340
+ثلاثة، فأنا مش حاجة أنسخ الـ DNA أو الـ strand
+
+841
+01:22:43,340 --> 01:22:48,000
+اللي هو من خمس إلى تلاتة، أنسخ العكس، من تلاتة إلى
+
+842
+01:22:48,000 --> 01:22:51,420
+خمس عشان أحصل على من خمس إلى تلاتة. أه، بس إحنا
+
+843
+01:22:51,420 --> 01:22:56,410
+يعني في الـ Standard، في تعاملنا،في عملية اللي إذا
+
+844
+01:22:56,410 --> 01:23:02,710
+بنعرف كهنا كانت Transcribed RNA أو Transcribed أو
+
+845
+01:23:02,710 --> 01:23:06,670
+في حالة اللي لما أنا أسوي report عن شو اللي اختلف
+
+846
+01:23:06,670 --> 01:23:12,750
+وكيف اختلف وكده بدي أقول إنه بتبدأ من خمسة بتروح
+
+847
+01:23:12,750 --> 01:23:17,270
+للثلاثة احفظوها بعد الشكل شايف علي؟ قلينا يعني
+
+848
+01:23:17,270 --> 01:23:23,210
+يمكن بدي الواحد يدخل تفاصيل أدقبس بعرفش إيه دا
+
+849
+01:23:23,210 --> 01:23:29,170
+يعني في كل الأوقات، في كل الظواهر بتتم بهذا الشكل،
+
+850
+01:23:29,170 --> 01:23:33,870
+ما بعرف، بس على قل هو المصطلح في التعامل مع هذا
+
+851
+01:23:33,870 --> 01:23:38,130
+الموضوع إنه أنا دايماً من خمس إلى ثلاث، إيه يخدها،
+
+852
+01:23:38,130 --> 01:23:42,550
+باتجاه اللي لما أقرأ الأشياء، بس واضح لما نسور DNA
+
+853
+01:23:42,550 --> 01:23:47,230
+replication إنه الجهتين بيشتغلوايعني لازم من خمس
+
+854
+01:23:47,230 --> 01:23:50,810
+لثلاث لثلاث خمس لما أنا بقصلهم بدي أبني هذا و أبني
+
+855
+01:23:50,810 --> 01:23:56,170
+هذا بدك تكون قادر على إنك تعمل شغلتين مع بعض فاهم
+
+856
+01:23:56,170 --> 01:24:01,510
+عليك كده على كل هذا أنا مش متأكد مية بالمية منه
+
+857
+01:24:01,510 --> 01:24:06,650
+خلينا شوية، ماشي؟ ما شاء الله في أسئلة ثانية؟
+
+858
+01:24:07,510 --> 01:24:11,270
+وغالبا يعني الطلاب بيتناقشوا على قضية اللي هو يعني
+
+859
+01:24:11,270 --> 01:24:13,910
+هذا المعلومات معظمها يعني مرت عليهم قبل هيك في ال
+
+860
+01:24:13,910 --> 01:24:18,730
+molecular وهم يعني يعني اللي اختلف عليهم قضية اللي
+
+861
+01:24:18,730 --> 01:24:22,830
+هو بالأرقام فهم بيسألوا على هذه النقطة لكن غالبا
+
+862
+01:24:22,830 --> 01:24:27,150
+يا دكاتر يعني نفس المعلومات اللي أخدتها بال
+
+863
+01:24:27,150 --> 01:24:31,870
+molecular هي يعني تنطبق هنا يعني هي تكملة لما سبق
+
+864
+01:24:31,870 --> 01:24:32,210
+يعني
+
+865
+01:24:35,540 --> 01:24:41,580
+في سؤال من دكتورة ويجدان في نقطة الـPolar Body
+
+866
+01:24:41,580 --> 01:24:46,660
+يعني هل الـPolar Body هو نفس الكوربس الوتيام؟ لا
+
+867
+01:24:46,660 --> 01:24:52,720
+طبعا، يعني هذه واحدة على مستوى النواء وواحدة على
+
+868
+01:24:52,720 --> 01:24:59,200
+مستوى الخلايا بشكل عاملأ، بالنسبة لهذا الموضوع
+
+869
+01:24:59,200 --> 01:25:05,880
+كوربوس الـ UTM هذا بعد الإخصاب وبعدين إشي مختلف
+
+870
+01:25:05,880 --> 01:25:11,880
+بولر بيدي في البويضة اللي لسه بدها تنتج قبل ما
+
+871
+01:25:11,880 --> 01:25:17,420
+تتلقى، بيكون معاها البويضة بيكون فيه two polar
+
+872
+01:25:17,420 --> 01:25:25,430
+bodies وهم يمثلوا إذا أخدنا الـ DNA 3Mكانت اللي ما
+
+873
+01:25:25,430 --> 01:25:31,890
+استفدناش منهم، فاهمة عليه؟ لأن أول كانت تكونت 4M،
+
+874
+01:25:31,890 --> 01:25:36,490
+وانقسمت لـ2 2M، لثنتين، كل واحدة فيها 2M، واحدة
+
+875
+01:25:36,490 --> 01:25:42,250
+منهم راح تجمد، وراح تضمر، وكذا، فبتظل واحدة فيها
+
+876
+01:25:42,250 --> 01:25:47,190
+2M، وبعدين لما تنقسم مرة ثانية وتصير 1N، اللي هي
+
+877
+01:25:47,190 --> 01:25:50,990
+الـEgg، برضه الواحدة الثانية اللي فيها 1N، راح
+
+878
+01:25:50,990 --> 01:25:56,780
+تضمر، فهي برضه راح تصير.ماشي؟ فيه برضه يعني شاف
+
+879
+01:25:56,780 --> 01:26:01,660
+الدكاترة بيرجع يسأله قبل فيه برضه سؤال بتقول
+
+880
+01:26:01,660 --> 01:26:05,880
+دكتورة أسماء فيه إمكانية إنه بس تعيد شرح نقطة
+
+881
+01:26:05,880 --> 01:26:12,160
+الـTelomere؟ الـTelomere هي قطعة في طرف
+
+882
+01:26:12,160 --> 01:26:20,840
+الـChromosome من فوق أو من تحت هي أنا تخيلي إنها
+
+883
+01:26:20,840 --> 01:26:28,710
+عبارة عن آليةلمعرفة عمر الخلية من ناحية قدرتها على
+
+884
+01:26:28,710 --> 01:26:37,070
+انقسام فزي مسبحة حكينا بيقدروا العلماء إنه الخلية
+
+885
+01:26:37,070 --> 01:26:41,790
+الـFertilized egg الجديدة الإنسان أول ما يولد، ليش
+
+886
+01:26:41,790 --> 01:26:47,150
+الإنسان مايظلوش مخلط؟ خلايا بيظلها إنه إلها قدرة
+
+887
+01:26:47,150 --> 01:26:52,870
+معينة على انقسام، بعدين بتتطل، تنقسمفهذه قلية ليش
+
+888
+01:26:52,870 --> 01:26:56,550
+العجوز أو الإنسان الكبير بالعمر وقلايا ما بتنقسم
+
+889
+01:26:56,550 --> 01:27:01,370
+جزء منه إنه الـ Telomere اللي هو الـ «تلي» يعني
+
+890
+01:27:01,370 --> 01:27:07,890
+بعيد أو مطرف فالـ Telomere فيه عبارة عن زي مسبحة
+
+891
+01:27:07,890 --> 01:27:12,990
+أو حبات مسبحة، كيف خير، في طرف الـChromosome بحيث
+
+892
+01:27:12,990 --> 01:27:18,560
+إنه مع كل انقسام حب بتطير، حب بتطير، حب بتطيرفلما
+
+893
+01:27:18,560 --> 01:27:23,540
+أنا بفترض تقديراً يعني بتوقع يمكن ما بعرفش رقم 100
+
+894
+01:27:23,540 --> 01:27:28,420
+% حوالي 60 حب لأنه يقال إن الخلايا تنقسم 60 مرة
+
+895
+01:27:28,420 --> 01:27:33,040
+ولمّا تنقسم 60 مرة هذا بتعطينا كمية مهولة جداً من
+
+896
+01:27:33,040 --> 01:27:40,560
+الخلايا يعني إشي كبير جداً فالـTelomere لما يعني
+
+897
+01:27:40,560 --> 01:27:45,780
+تسمع في الكتب أو في الدراسات يقولّك والله النعجة
+
+898
+01:27:45,780 --> 01:27:53,840
+دوليصحيح ولدت من خلية أمها اللي هي يعني ولدت اليوم
+
+899
+01:27:53,840 --> 01:28:00,680
+بس حقيقة يعني الأم كانت مثلا نفترض زي مثلا نفترض
+
+900
+01:28:00,680 --> 01:28:06,900
+بشر إنسان عمره ثلاثين سنة واخدت منه خلية نقلتها في
+
+901
+01:28:06,900 --> 01:28:11,820
+استنساخ عملت خلية ثانية وكائن بشري تاني الطفل أو
+
+902
+01:28:11,820 --> 01:28:16,130
+الإنسان هذا لما يولد عمره ثلاثين مش عمره يوميعني
+
+903
+01:28:16,130 --> 01:28:21,590
+ما يعني إذا الإنسان بعيش سبعين سنة الإنقسامات
+
+904
+01:28:21,590 --> 01:28:25,710
+الباقية له اللي هي أربعين سنة عشان هيك المعجد دول
+
+905
+01:28:25,710 --> 01:28:31,450
+ماتت مبكراً، شايخوها مبكراً لأنه قليتها عمرها كبير
+
+906
+01:28:31,450 --> 01:28:37,570
+بسبب إنه الـ… شو اسمه؟ قليتها عمرها كبير بسبب إنه
+
+907
+01:28:37,570 --> 01:28:44,350
+الـ… الـ… شو اسمه؟ الـTelomeres دولة أقللأن
+
+908
+01:28:44,350 --> 01:28:48,570
+المسبحة انقسم منها كثير بالانقسامات القديمة يعني
+
+909
+01:28:48,570 --> 01:28:54,750
+بهذا الشكل بدنا نفهمه، واضح؟ إن شاء الله يكون
+
+910
+01:28:54,750 --> 01:28:59,930
+الجواب يعني وصل إلى الدكتورة أسماء الدكتورة هذه
+
+911
+01:28:59,930 --> 01:29:03,410
+اللي بتقول يعني الـPolar Body خلية فيها Cytoplasm
+
+912
+01:29:03,410 --> 01:29:08,230
+قليل يعني نعم، صحيح، وجاي على الطرف، يعني الجسم
+
+913
+01:29:08,230 --> 01:29:15,260
+القطبي الـPolar يعني قطبي، صحيح؟ أهطبعًا، لحد الآن
+
+914
+01:29:15,260 --> 01:29:19,500
+الأسئلة هي كذلك، تم الإجابة عليها تقريبًا ومعظمها
+
+915
+01:29:19,500 --> 01:29:24,880
+نقطة الأخيرة، واللي خلّينا على الموضوع هذا طويل،
+
+916
+01:29:24,880 --> 01:29:29,080
+صارت الساعة عشرة فموعدنا غدا إن شاء الله ساعة
+
+917
+01:29:29,080 --> 01:29:33,420
+تمانية ونص، ونبدأ من هذه النقطة إذن الله تعالى، بس
+
+918
+01:29:33,420 --> 01:29:38,260
+بعد إذنك يا دكتور إذا الـ PowerPoint بالظبط ببعتلك
+
+919
+01:29:38,260 --> 01:29:44,060
+الآن محاضرتين، اليوم وبكرة إن شاء الله رب العالمبس
+
+920
+01:29:44,060 --> 01:29:48,320
+يبقى نفسي اللي في الكتابفي الغالب ما جبتش إشي
+
+921
+01:29:48,320 --> 01:29:52,580
+خارجي، ماشي، ماشي فيه بس بعد إذنك يا دكتور قبل ما
+
+922
+01:29:52,580 --> 01:29:57,300
+ننهي فيه يعني كان اقتراح من بعض الطلاب بخصوص ال
+
+923
+01:29:57,300 --> 01:30:04,400
+slides لو يتم بس يعني كتابة بعض النقاط يعني بعد
+
+924
+01:30:04,400 --> 01:30:09,480
+الصور أو كذا عشان تكون معينة يعني على الخلال عملية
+
+925
+01:30:09,480 --> 01:30:13,500
+التدوين في الشرح المتابع للشرح يعني بعض النقاط
+
+926
+01:30:13,500 --> 01:30:18,950
+الرئيسية اللي بتكلم عن كل صورةاسمع علي، المرجع
+
+927
+01:30:18,950 --> 01:30:25,730
+بصراحة ثري جدا وعميق الأصل
+
+928
+01:30:25,730 --> 01:30:29,590
+يعني إذا الواحد ماعندهوش قدرة أو يمكن تفاصيل
+
+929
+01:30:29,590 --> 01:30:35,470
+المعلومات هي جيدة تكون مرجع لوحد مثلا بدهو يعطي
+
+930
+01:30:35,470 --> 01:30:40,870
+المحاضرة أو بده يفهم نقطة محددة بشكل دقيق يعني زي
+
+931
+01:30:40,870 --> 01:30:44,490
+اللي أختك بتفهم عن Polar Body بشكل أدق ولا كده
+
+932
+01:30:44,990 --> 01:30:50,290
+فبتلاقي يمكن فقرة جوا موجودة أنا بعتبر إنه مدان ما
+
+933
+01:30:50,290 --> 01:30:56,210
+ركزتش عليها يعني إنها مش كتير مهمة لكم يعني فالآن
+
+934
+01:30:56,210 --> 01:31:03,410
+اللي أنا بفضل إنه يعني كل محاضرة عبارة عن فصل من
+
+935
+01:31:03,410 --> 01:31:09,890
+الكتاب الفصل هتلاقي فيه مقدمة، فيه جداول، في
+
+936
+01:31:09,890 --> 01:31:16,640
+الرسمات هي بنعرضهابالأخير فيه يعني ملخص فأنا اللي
+
+937
+01:31:16,640 --> 01:31:21,840
+باقترحه إنه كمان الواحد يرجع للنقاط الرئيسية في
+
+938
+01:31:21,840 --> 01:31:30,020
+الكتاب اللي هي العناوين الجداول الصور إذا إشي حاطب
+
+939
+01:31:30,020 --> 01:31:33,520
+بنت عليه عريض هذه اللي الواحد الأشياء اللي يركز
+
+940
+01:31:33,520 --> 01:31:39,900
+عليها فإنتوا كمان يعنيالتفاريغ دايماً بقول كانت
+
+941
+01:31:39,900 --> 01:31:44,080
+مفيدة إليه لما أنا أكون اللي كتبتها، أن أنا بتذكر،
+
+942
+01:31:44,080 --> 01:31:47,940
+فاسمعوا كلامي وشوفوا الكتاب، ارجعوا هيك إليه
+
+943
+01:31:47,940 --> 01:31:52,180
+بسرعة، لا تضيعوا وقتك كثير في تفاصيل المعلومات
+
+944
+01:31:52,180 --> 01:31:58,120
+الخط الصغير، المعلومات الكثيرة، يعني هي بتعينك على
+
+945
+01:31:58,120 --> 01:32:02,180
+الفهم بشكل اللي يعني من خلال زي ما أنا بقول هيك،
+
+946
+01:32:02,180 --> 01:32:07,870
+بشرح كيف تظهر هذا بالتم أو كيفكذا، أما التفاصيلة
+
+947
+01:32:07,870 --> 01:32:13,190
+مش راح تكون يعني إذا الفاحد فهم المبدأ و القاعدة
+
+948
+01:32:13,190 --> 01:32:17,830
+زي ما بيقوله بيقدر يتكر الأشياء بإذن الله تعالى،
+
+949
+01:32:17,830 --> 01:32:20,490
+ان شاء الله رب العالمين، يعطيك العفو يا دكتور الله
+
+950
+01:32:20,490 --> 01:32:23,530
+يرضي عليكم، نراح نقتل إن شاء الله، إن شاء الله رب
+
+951
+01:32:23,530 --> 01:32:27,470
+العالمين، نكمل من هنا، السلام عليكم، السلام عليكم،
+
+952
+01:32:27,470 --> 01:32:28,010
+في رعاية الله
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/QjHQ6ziYtVc_raw.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/QjHQ6ziYtVc_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..3f52aa782741b37806d9f36a1979a8c996f1f5b1
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/QjHQ6ziYtVc_raw.srt
@@ -0,0 +1,3833 @@
+1
+00:00:00,000 --> 00:00:07,320
+بسم الله الرحمن الرحيم في المحاضرة السابقة كنا
+
+2
+00:00:07,320 --> 00:00:15,780
+نتكلم عن تركيب الـ DNA والمادة الأورافية وكيف هي
+
+3
+00:00:15,780 --> 00:00:24,980
+موجودة في خلايانا ووصلنا ووقفنا شوية عند هذه
+
+4
+00:00:24,980 --> 00:00:29,840
+الصورة واتناقشنا فيها شوية، اللي هييعني حاطين فيها
+
+5
+00:00:29,840 --> 00:00:36,520
+مبادئ إنه داخل الـ Chromosome بيكون الـ DNA على
+
+6
+00:00:36,520 --> 00:00:41,920
+شكل اللي هو الـ Double Helix السلم اللولبي وإنه
+
+7
+00:00:41,920 --> 00:00:48,360
+لما نحنا نيجي نتعامل معاه دائما ناخد الأصل اللي
+
+8
+00:00:48,360 --> 00:00:53,630
+يكون اللي هو القطعة اللي ماشية من الجهةالـFive
+
+9
+00:00:53,630 --> 00:00:58,150
+Prime لـThree Prime يعني بترتيب معين طبعاً لأن
+
+10
+00:00:58,150 --> 00:01:03,710
+الـDouble Helix الدرجات تبعاته عبارة عن الـPurine
+
+11
+00:01:03,710 --> 00:01:07,870
+و البريميدين نوعين من القواعد النيتروجينية
+
+12
+00:01:07,870 --> 00:01:15,110
+وبالتالي كل واحد بيرتبط مع نوع آخر محدد يعني ففي
+
+13
+00:01:15,110 --> 00:01:21,390
+أي موقع بكون أنا عندي أربع احتمالات الـC و الـG و
+
+14
+00:01:21,390 --> 00:01:27,660
+الـA و الـTوبالتالي المكافئة
+
+15
+00:01:27,660 --> 00:01:33,960
+له بيكون محددة، طريقة محددة فالصورة
+
+16
+00:01:33,960 --> 00:01:41,660
+هذه سببت إشكالية شوية اللي هي إنه إحنا لما نتعامل
+
+17
+00:01:41,660 --> 00:01:47,760
+مع الـ «DNA» ومن هدول الأحرف الأربعةالواحد من
+
+18
+00:01:47,760 --> 00:01:53,000
+الأربعة إنه عشر أقصد تسعة ثلاثة في عشر أقصد تسعة
+
+19
+00:01:53,000 --> 00:01:57,680
+وتلت مليارات نيتروجين
+
+20
+00:01:57,680 --> 00:02:05,150
+أسبايس أو Nucleotidesوبكونوا لما نتعامل معها في
+
+21
+00:02:05,150 --> 00:02:13,490
+حالات قراءتها في القراءتها في الـ…. في أي خلية أو
+
+22
+00:02:13,490 --> 00:02:16,870
+في خلية بني آدم معين زي ما سوّينا في الـHuman
+
+23
+00:02:16,870 --> 00:02:23,030
+Genome طلعنا ما يسمى في مأي موقع معين، في Gen معين
+
+24
+00:02:23,030 --> 00:02:26,790
+أنا مهتم فيه، بقول، بطلع الـReference Sequence
+
+25
+00:02:26,790 --> 00:02:32,080
+وهذا اللي بعتمده من خلالالـ Human Genome Project
+
+26
+00:02:32,080 --> 00:02:38,000
+هذا بعتبره المرجع بالنسبة لي فإذا أنا بعمل دراسة
+
+27
+00:02:38,000 --> 00:02:42,780
+معينة وهي فرضية أو افتراض في حالة معينة إنه أنا
+
+28
+00:02:42,780 --> 00:02:47,160
+جيت أركز بسبب المرض أو الحالة أو الإشي اللي أنا
+
+29
+00:02:47,160 --> 00:02:53,480
+بدرسه فيه جيت درست مجموعة أشخاص الشخص الأول الصدفة
+
+30
+00:02:53,480 --> 00:02:56,900
+هيك أو طلع معاه إنه طلعت تماما زي الـReference
+
+31
+00:02:56,900 --> 00:03:02,630
+Sequence وكان هذا الشخص الأولفي الشخص الثاني
+
+32
+00:03:02,630 --> 00:03:07,550
+والثالث كان فيه تبديل في أحد القواعد النيتروجينية
+
+33
+00:03:07,550 --> 00:03:11,890
+وهذا بيصير ومش كل الناس زي بعض عشان هيك أحنا
+
+34
+00:03:11,890 --> 00:03:19,350
+مختلفين فبتلاقوا الواحد في الموقع هذا بدل ما هي
+
+35
+00:03:19,350 --> 00:03:25,850
+جاي T صار C نيكليوتايد أو nitrogenous base فهذا
+
+36
+00:03:25,850 --> 00:03:32,150
+إنسان مختلف بشكل بسيطحتى بيسموهم Snips Single
+
+37
+00:03:32,150 --> 00:03:37,270
+Nucleotide Polymorphisms يعني إنه فيه اختلاف في
+
+38
+00:03:37,270 --> 00:03:41,770
+حرف واحد من الأحرف الأربعة في موقع معين والشخص
+
+39
+00:03:41,770 --> 00:03:46,810
+التاني والتالت في هذا الموقع متشابهين الشخص الرابع
+
+40
+00:03:46,810 --> 00:03:52,690
+في عنده تبديل آخر في موقع آخر في حرف آخر ممكن تحدث
+
+41
+00:03:52,690 --> 00:03:59,140
+بهذه الطريقة والشخص الخامس كان عنده إنهطول الـ DNA
+
+42
+00:03:59,140 --> 00:04:03,800
+في هذا الموقع أقصر بحيث أنه صار فيه إزالة لإنواعين
+
+43
+00:04:03,800 --> 00:04:11,740
+وهذه يعني كأنها تمثل نوع من يعني لما يجي الطبيب أو
+
+44
+00:04:11,740 --> 00:04:16,700
+العالم أو الباحث يجي يدرس موقع معين لمرض معين أو
+
+45
+00:04:16,700 --> 00:04:21,000
+لحالة معينة ويدرس مجموعة من البشر ويلاقي هذه
+
+46
+00:04:21,000 --> 00:04:26,960
+الاختلافات بهذا الشكل لا تعني شيءيعني من ناحية
+
+47
+00:04:26,960 --> 00:04:32,300
+الآن إنه ناخدها إنه هذا يمثل مرض أو نتيجتها كذا أو
+
+48
+00:04:32,300 --> 00:04:39,700
+كذا يعني بس بقدر ما إنها هي أمثلة لطريق
+
+49
+00:04:39,700 --> 00:04:45,180
+دراسة الـ DNA بالأيام الحالية إنه دائما نستخدم الـ
+
+50
+00:04:45,180 --> 00:04:51,710
+PCR بحيث إنه نطلع شو الترتيب الحالي للـأحرف تبعات
+
+51
+00:04:51,710 --> 00:05:00,210
+الـ Nucleotides أو الـ DNA وكذلك النقطة اللي بعدها
+
+52
+00:05:00,210 --> 00:05:03,610
+إنه
+
+53
+00:05:03,610 --> 00:05:09,210
+22 أو 23 زوج من الكرموزومات 22 متشابقة جسمية
+
+54
+00:05:09,210 --> 00:05:18,210
+تقريبًا يعني حسب الـ Graph هذاكل ما يعني هو
+
+55
+00:05:18,210 --> 00:05:26,150
+تقريبًا ذكرنا فيه حوالي 25 ألف جين
+
+56
+00:05:26,150 --> 00:05:32,050
+في الـHuman Genome هذا تقديرهم حسب الـHuman Genome
+
+57
+00:05:32,050 --> 00:05:37,830
+Project فتقريبًا إنه الإنسان يقدر إنه في كل
+
+58
+00:05:37,830 --> 00:05:42,390
+كروموزوم فيه حوالي ألف تقريبًا بس فيه تفاوض شديد
+
+59
+00:05:42,390 --> 00:05:48,100
+يعني الكروموزوم رقم واحديعني بنلاقي في آخر الـ
+
+60
+00:05:48,100 --> 00:05:53,380
+«جدوس» الـ «جراف» هذا في أعلى شيء حجمه أكبر شيء
+
+61
+00:05:53,380 --> 00:05:59,900
+حوالي 250 ميجابيز يعني مليون قاعدة بهذا الشكل
+
+62
+00:05:59,900 --> 00:06:07,960
+ويقدر أنه في حوالي 2000 جين عدد الجينات أو القطع
+
+63
+00:06:07,960 --> 00:06:15,610
+اللي تحول إلى بروتين فـهكذا ترتيب وتوزيع الـ… الـ…
+
+64
+00:06:15,610 --> 00:06:22,170
+الـ«كروموزومات» تبع الـDNA في النواة وطبعًا بنلاحظ
+
+65
+00:06:22,170 --> 00:06:27,010
+أنه في الـX والـY كروموزومات الـX هو الأكبر واللي
+
+66
+00:06:27,010 --> 00:06:36,190
+فيه جينات أكثر الـY فقير للجينات يعني حوالي ممكن
+
+67
+00:06:36,190 --> 00:06:41,890
+خمسين جين أو عدد قليل من الجينات وهذه تمت دراستها
+
+68
+00:06:41,890 --> 00:06:42,510
+سابقًا
+
+69
+00:06:45,000 --> 00:06:50,340
+محاضرة الاستكمال، محاضرة اليوم نبدأ بوصف الظواهر
+
+70
+00:06:50,340 --> 00:06:56,660
+اللي بتحدث إنه نتيجة تكاثر الجسم وتكون الإنسان
+
+71
+00:06:56,660 --> 00:07:02,940
+اتداعاً من خلية واحدة اللي هي الـFertilized Egg من
+
+72
+00:07:02,940 --> 00:07:08,280
+أولها إلى آخر يوم في حياته يكون هناك انقسام في
+
+73
+00:07:08,280 --> 00:07:12,120
+الخلايا وهناك نوعين من انقسام وكلها معلومات
+
+74
+00:07:12,120 --> 00:07:18,430
+تعرفوهاإذا في حد عنده أي استفسار يوقفني وإذا
+
+75
+00:07:18,430 --> 00:07:24,390
+الأمور واضحة بنكمل الانقسام
+
+76
+00:07:24,390 --> 00:07:31,530
+على نوعين فيه الانقسام الجسماني أو الانقسام اللي
+
+77
+00:07:31,530 --> 00:07:36,330
+هو الـ Mitotic باللغة الإنجليزية وهناك الـ Meiosis
+
+78
+00:07:36,330 --> 00:07:42,430
+اللي هو الانقسام المنصف فالانقسام للخلايا العادية
+
+79
+00:07:43,250 --> 00:07:50,590
+بكون أنهم يعني توصف بأنها تمر في cell cycle في
+
+80
+00:07:50,590 --> 00:07:58,230
+دورة حياة الخلية فأنها تكون تؤدي وظائفها وتعمل حسب
+
+81
+00:07:58,230 --> 00:08:04,770
+أنواع مختلفة من الخلايا بتكون بالـ G1 phase يعني
+
+82
+00:08:04,770 --> 00:08:08,570
+اللي هي في مرحلة أنها تكون خلية عادية تقوم
+
+83
+00:08:08,570 --> 00:08:11,530
+بوظيفتها حسب الاشي المطلوب منها
+
+84
+00:08:14,460 --> 00:08:22,280
+النواة بيكون المادة الوراثية فيها زي الخيط الفالد
+
+85
+00:08:22,280 --> 00:08:29,660
+وما في داعي يكون مربوط أو مكور بشكل مضغوط حتى يتم
+
+86
+00:08:29,660 --> 00:08:37,380
+عملية الانقسام عند حدوث أو تهيأ لبداية الانقسام
+
+87
+00:08:39,710 --> 00:08:48,090
+بتم يعني بعد ما تكون في حالة الـG1 تدخل في المرحلة
+
+88
+00:08:48,090 --> 00:08:53,350
+ما تسمى الـS phase وهي المرحلة اللي يتم فيها إعادة
+
+89
+00:08:53,350 --> 00:09:01,550
+أو مضاعفة تكوين الـDNA والكرموزومات بشكل كامل بحيث
+
+90
+00:09:01,550 --> 00:09:06,330
+أنه تصبح للخلية نسختين من المادة الوراثيةالـ
+
+91
+00:09:06,330 --> 00:09:12,830
+Chromosome يعني بشكل مهم حتى يشترك في هذه العملية
+
+92
+00:09:12,830 --> 00:09:20,970
+بيكون يصبح على شكل مضغوط ويكون على شكل يعني قطعة
+
+93
+00:09:20,970 --> 00:09:27,550
+الـ الـ الـ DNA الملفوف بشكل شديد ومضغوط ويلديه
+
+94
+00:09:27,550 --> 00:09:34,640
+حتى يتم فصله على جهتين الخليتين المفصلات بعدينبكون
+
+95
+00:09:34,640 --> 00:09:41,580
+عنده «سينترومير» اللي هو النقطة عليه التي يتم جذب
+
+96
+00:09:41,580 --> 00:09:50,420
+الكرمزومين المتشابهين إلى زاويتين خلايتين متكونتين
+
+97
+00:09:50,420 --> 00:09:55,100
+جديدتين فالـ «سينترومير» هذا وظيفته بيشبك مع الـ
+
+98
+00:09:55,100 --> 00:09:58,970
+«Spindle» للـ «سينتروزونز» على الجوانبوهناك ما
+
+99
+00:09:58,970 --> 00:10:06,130
+يسمى التلومير التلومير هي يعني بدك تشبهها بمسبحة
+
+100
+00:10:06,130 --> 00:10:13,310
+على طرف ونهاية الكرموزومات التلومير حد بيقدر يقول
+
+101
+00:10:13,310 --> 00:10:23,130
+إنه عشان أفهم إنه اللي معاي سامعيني واضح التلومير
+
+102
+00:10:23,130 --> 00:10:29,420
+إيه له قصة يعنييعني بيجيزوا يعني جيد الواحد يتنبه
+
+103
+00:10:29,420 --> 00:10:38,280
+لها الـ Telomere يعني يقدر يعني هذا التقدير أنه
+
+104
+00:10:38,280 --> 00:10:45,600
+الخلايا من بداية تكون النطفة المخصبة أو الـ
+
+105
+00:10:45,600 --> 00:10:50,880
+Fertilized Egg أنه تمتلك حوالي ستين مرة من القدرة
+
+106
+00:10:50,880 --> 00:10:56,870
+على الإنقسام وهذا العدد الإنقسامات هذه الستينإثنين
+
+107
+00:10:56,870 --> 00:11:02,550
+لعشرة، إثنين لأس ستين، إذا بتتذكروا قصة اللي اخترع
+
+108
+00:11:02,550 --> 00:11:06,730
+لعبة
+
+109
+00:11:06,730 --> 00:11:12,290
+الشطرانج أنه طلب للملك طلب الملك اللي قلّه اطلب
+
+110
+00:11:12,290 --> 00:11:18,030
+اللي بدكيا واطمناه بله بسيطة بدي تحطلي حبة قمح في
+
+111
+00:11:18,030 --> 00:11:24,300
+أول مربع في الـ 64 مربعوبعدين تحطي لي حبتين قمح
+
+112
+00:11:24,300 --> 00:11:29,660
+بالمربع الثاني أو أربع حبات ويضاعف كل مرة فثبت إنه
+
+113
+00:11:29,660 --> 00:11:34,820
+يعني كل إنتاج العالم من القمح لن يكفي لتغطية هذا
+
+114
+00:11:34,820 --> 00:11:40,740
+الطلب فـ 60 انقسام يعني كمية مهولة جدا ينتج عنها
+
+115
+00:11:40,740 --> 00:11:47,860
+ما بديش أقول مليارات المليارات من الخلايا فحتى يتم
+
+116
+00:11:47,860 --> 00:11:53,210
+التحكم بهذا الأمرفي نهاية الكروموزوم يكون هناك مثل
+
+117
+00:11:53,210 --> 00:12:00,350
+المسبحة فيها ستين حبة بحيث مع كل انقسام بتطير حبة
+
+118
+00:12:00,350 --> 00:12:04,610
+من المسبحة هذه بحيث عشان هيك يعني دراسة الـ
+
+119
+00:12:04,610 --> 00:12:12,010
+Telomere في أول كائن مستنسخ من خلية يعني جبوها
+
+120
+00:12:12,010 --> 00:12:17,960
+بطريقة مختلفة اللي هي النعجة «دولي»كتبت إنه حتى
+
+121
+00:12:17,960 --> 00:12:23,760
+عند ولادتها هي تقريبًا بمثل عمر إمها بسبب إن الـ
+
+122
+00:12:23,760 --> 00:12:30,460
+Telomere تبعها كان أقصر فهذا جانب مهم للتحكم
+
+123
+00:12:30,460 --> 00:12:35,780
+في العملية الكلية لقضية انقسام الخلايا في الجسم
+
+124
+00:12:35,780 --> 00:12:41,340
+فهناك ما يسمى الـ Telomeresدكتور، بعد إذنك، في
+
+125
+00:12:41,340 --> 00:12:45,760
+سؤال من الدكتور «أسديهان» بخصوص وظيفة الـ
+
+126
+00:12:45,760 --> 00:12:53,280
+«سينترومير» «سينترومير» هو المركز اللي يعني احنا
+
+127
+00:12:53,280 --> 00:13:01,100
+راح .. هون إذا بتنتبه الخلية هذه كانت واحدة تضاعف
+
+128
+00:13:01,100 --> 00:13:07,500
+الـ DNA اللي فيها فبعد ذلك انقسمت نص إلى خليتين
+
+129
+00:13:08,350 --> 00:13:12,810
+والسبب في الانقسام أنه هناك راح يكون حاجة نحكي
+
+130
+00:13:12,810 --> 00:13:17,370
+عنها «سينتروزوم» مش «سينترومير»، «سينتروزوم» بيكون
+
+131
+00:13:17,370 --> 00:13:23,150
+بالطرف من الجهتين الخليتين اللي راح يتكونوا وراح
+
+132
+00:13:23,150 --> 00:13:30,830
+يتم جد الـ «كرومزومات» أو الـ «كروماتيد» لكل طرف
+
+133
+00:13:30,830 --> 00:13:35,790
+عن طريق اللي هم يعني الـ Spindle Fibers بقولهم
+
+134
+00:13:36,280 --> 00:13:39,620
+وبيشبكوا ما بين الـ Centrosome مع الـ Centromere
+
+135
+00:13:39,620 --> 00:13:51,280
+حتى يفصل الـ DNA إلى نصفين متساوية، واضحة؟ فالـ
+
+136
+00:13:51,280 --> 00:13:58,420
+Centromere هو قطعة في الـ DNA، في الـ Chromosome
+
+137
+00:13:58,420 --> 00:14:06,510
+وظيفتها تسهيل والتحكم في عملية فصل نصفيالـ
+
+138
+00:14:06,510 --> 00:14:13,330
+Chromosomes إلى طرفي الخلية المنقسمة، ماشي؟ لسه
+
+139
+00:14:13,330 --> 00:14:16,370
+برضه النقطة يبدو أنها ما واضحة تقريبا راح نشوفها
+
+140
+00:14:16,370 --> 00:14:21,010
+بعدين بشكل تفصيلي، يعني الآن مش راسمينها، بس راح
+
+141
+00:14:21,010 --> 00:14:26,550
+تيجي مرة ثانية، ماشي؟ راح نشوفها كثير، إشي ضروري
+
+142
+00:14:26,550 --> 00:14:34,030
+عشان نقدر نفصلهم، يعني إذا أنا مثلا عندي Top 10
+
+143
+00:14:34,030 --> 00:14:40,220
+خيطوبدي أفصلهم عن بعض، لازم من مكان معين أمسكهم
+
+144
+00:14:40,220 --> 00:14:45,040
+عشان أجرهم للجهتين المختلفتين، فهذا المكان في
+
+145
+00:14:45,040 --> 00:14:49,820
+الـChromosome هو الـCentromere، وإله أشياء وبعدين
+
+146
+00:14:49,820 --> 00:14:58,840
+تاخدوها في الطب السريري يعني، ماشي، فالآن لما
+
+147
+00:14:58,840 --> 00:15:08,950
+نتكلم على دواهر أو تسمي أخرىبتكون الخلايا في الـ
+
+148
+00:15:08,950 --> 00:15:19,170
+G1 يعني هنا الـ G1 حاطينه بهذا الشكل اللي هو
+
+149
+00:15:19,170 --> 00:15:24,350
+الخلية في المرحلة تبعتها بتمر في مرحلة إحنا ما
+
+150
+00:15:24,350 --> 00:15:28,070
+بنشوفها اللي هي الـ S-phase للاستعداد لعملية
+
+151
+00:15:28,070 --> 00:15:34,450
+الانقسام بتتم فيها عملية إعادةأو مضاعفة كمية
+
+152
+00:15:34,450 --> 00:15:40,950
+الـDNA لما يتضاعف الخلية تصبح لديها ضعف كمية
+
+153
+00:15:40,950 --> 00:15:47,090
+الـDNA تبدأ تدخل في عملية الانقسام فالانقسام بيتم
+
+154
+00:15:47,090 --> 00:15:52,430
+في حملة الـG2 أو بعد ما تدخل الـG2 تكتر تحت شوية
+
+155
+00:15:52,430 --> 00:15:58,130
+تبدأ تدخل في الـmitosis الـmitosis اللي هو
+
+156
+00:15:58,130 --> 00:16:04,500
+الانقسام الطبيعيبتبدأ بالـ Interphase، تدخل بالـ
+
+157
+00:16:04,500 --> 00:16:07,480
+Prophase، وبعدين Pro-Metaphase، Metaphase،
+
+158
+00:16:07,480 --> 00:16:13,060
+Anaphase، Telophase، وبعدين Cytokinesis، تنقسم
+
+159
+00:16:13,060 --> 00:16:21,660
+شوية المراحل، بدنا نشوف الظواهر التالية هنا صار
+
+160
+00:16:21,660 --> 00:16:28,120
+عندي ضعف كمية الـ DNA فلما تبدأ عملية الانقسام،
+
+161
+00:16:28,120 --> 00:16:35,690
+أول شيءالـ Centrosomes تظهر يعني بتتكوّر بشكل أقوى
+
+162
+00:16:35,690 --> 00:16:42,710
+وأوضحه بدي إثنين منهم الخطوة التالية إنه بعد ما
+
+163
+00:16:42,710 --> 00:16:50,610
+كان الخيط أو الـ DNA فالت وطويل وغير ظاهر داخل
+
+164
+00:16:50,610 --> 00:17:00,010
+النواء يتم تكتيفه والتواءه على بعض بحيث يكوّنالـ
+
+165
+00:17:00,010 --> 00:17:03,870
+Chromatids والـ Chromosomes بالشكل اللي ابنراها
+
+166
+00:17:03,870 --> 00:17:09,590
+هنا لما يبدوا يظهروا تبدأ أن الخلية هذه مستعدة
+
+167
+00:17:09,590 --> 00:17:14,290
+لعملية الإنقسام وتسمى هذه مرحلة الـ Prophase بيصير
+
+168
+00:17:14,290 --> 00:17:19,330
+أن الـ Ocentrosome يظهر الـ Chromatin أو الـ
+
+169
+00:17:19,330 --> 00:17:25,050
+Chromosomes تظهر بعد ما كانت القيوط فارقة بتصير
+
+170
+00:17:25,050 --> 00:17:34,150
+تندغط وبعد ذلكيزول غلاء غشاء النواعي الـNuclear
+
+171
+00:17:34,150 --> 00:17:41,950
+Membrane بيختفي فهذه الظواهر اللي بتحدث أو بتبدأ
+
+172
+00:17:41,950 --> 00:17:46,330
+تحدث بالـProphase الـProphase بعدها بتدخل
+
+173
+00:17:46,330 --> 00:17:52,170
+بالـPrometaphase بيصير Indicator عليه إنه
+
+174
+00:17:52,170 --> 00:17:58,550
+الـCentrosomes تتجه إلى الطرفين في الخليةيعني
+
+175
+00:17:58,550 --> 00:18:04,350
+بيروحوا من هون وهون والـ «Chromatids» والـ
+
+176
+00:18:04,350 --> 00:18:12,290
+«Chromosomes» بتبدأ ترتبط من خلال أو يعني بواسطة
+
+177
+00:18:12,290 --> 00:18:18,470
+أو من محل الـ «Centrosomes» اللي آسف «Centromeres»
+
+178
+00:18:18,470 --> 00:18:22,810
+اللي حكت أنا زي ما سألت أنا قبل شوية هي المنطقة
+
+179
+00:18:22,810 --> 00:18:26,890
+اللي هتربط باللي هيسمى الـ «Spindle Fibers» إبارة
+
+180
+00:18:26,890 --> 00:18:34,780
+عنتقريبًا خيوط عضلية مركباتها تشبه العضلات فالـ
+
+181
+00:18:34,780 --> 00:18:40,760
+Centrosomes بيربطوا بالـ Centromere من خلال الـ
+
+182
+00:18:40,760 --> 00:18:45,040
+Spindle Fibers ففي
+
+183
+00:18:45,040 --> 00:18:51,520
+الـ Pro Metaphase تبدأ الظاهرة تتكون أكثر والـ
+
+184
+00:18:51,520 --> 00:18:56,740
+Chromosomes بتتشكل بشكل مضغوط جدًاوبشكل، بهذا
+
+185
+00:18:56,740 --> 00:19:02,960
+الشكل الذي نراه ولمّا حتى يتم عملية فصلهم إلى
+
+186
+00:19:02,960 --> 00:19:11,880
+الطرفين ونقطتين بتصير عملية الـMetaphasis إنه أنا
+
+187
+00:19:11,880 --> 00:19:20,080
+برتب كل زوج من الكروموزومات لأن هنا بتصير الـ…
+
+188
+00:19:20,080 --> 00:19:26,310
+الـ… الـ… الـDNA يُقال له «4N»يعني عندي ضعف كمية
+
+189
+00:19:26,310 --> 00:19:33,550
+الـ DNA فكل قطعتين متشابهات يقفوا بالنص في مستوى،
+
+190
+00:19:33,550 --> 00:19:38,810
+في نص الخلية ويكون على الطرفين الـ Centrosomes
+
+191
+00:19:38,810 --> 00:19:43,310
+ودولة اسمهم Spindle Fibers ويكون عندي الـ
+
+192
+00:19:43,310 --> 00:19:48,290
+Chromosomes بالنص فهدولة بيسموها Microtubules يعني
+
+193
+00:19:48,290 --> 00:19:55,480
+اللي هم زي خيوط العضلية بعد ذلك يبدأ شدالكرموزومات
+
+194
+00:19:55,480 --> 00:20:02,440
+للطرفين فهذه مرحلة الـ Anaphase فـInterphase،
+
+195
+00:20:02,440 --> 00:20:05,700
+Prophase، Prometaphase، Metaphase، Anaphase،
+
+196
+00:20:05,700 --> 00:20:11,300
+Telophase وبعدين تنقسم الخلية فبتم عملية الشد
+
+197
+00:20:11,300 --> 00:20:17,720
+للطرفين لما تنتهي وتصبح كل مجموعة الكرموزومات في
+
+198
+00:20:17,720 --> 00:20:24,410
+جهةتبدأ الـ Telophase إنه الخلية بتبدأ تنقسم تتخصر
+
+199
+00:20:24,410 --> 00:20:30,250
+في المنتصف وبعدين تنقسم إلى خليتها بعدها بيرجع
+
+200
+00:20:30,250 --> 00:20:36,270
+لشعر نواء ظاهر بيتكوّن مرة ثانية وبرجع الـ DNA يفك
+
+201
+00:20:36,270 --> 00:20:42,050
+وبتصير Decondensed كروماتين يعني الكرومازومات غير
+
+202
+00:20:42,050 --> 00:20:50,690
+مضغوطةهذا الإنقسام الطبيعي وبكون نتيجته إنه كل
+
+203
+00:20:50,690 --> 00:21:01,110
+خلية لديها 2N-DNA لديها DNA متشابه
+
+204
+00:21:01,110 --> 00:21:07,870
+تمامًا وبكون يعني مطابق للـDNA اللي كان موجود في
+
+205
+00:21:07,870 --> 00:21:13,010
+الخلية الأصلية فهذه الظاهرة في عملية الإنقساموأي
+
+206
+00:21:13,010 --> 00:21:18,910
+خلية بتنقسم وهذه كلها يعني معرفة المعلومات هذه
+
+207
+00:21:18,910 --> 00:21:23,630
+اللي دخل في حتى معرفة الأدوية معرفة الأمراض معرفة
+
+208
+00:21:23,630 --> 00:21:28,350
+الأشياء بعد ذلك يعني ما يخرب الـMicrotubules اللي
+
+209
+00:21:28,350 --> 00:21:32,330
+هم الـConscious من الأدوية اللي نستخدم للنقرص
+
+210
+00:21:32,330 --> 00:21:36,850
+واللي نستخدمه في أدوية كثيرة بتلاقيها تاريخهم يؤثر
+
+211
+00:21:36,850 --> 00:21:40,940
+على الـMicrotubulesفي مرات الـ Antibody تتكون
+
+212
+00:21:40,940 --> 00:21:47,400
+تدوسنترومير اللي هو موجود في منتصف الكروموزوم
+
+213
+00:21:47,400 --> 00:21:51,140
+Anticentromere Antibody في الـ Crest أو
+
+214
+00:21:51,140 --> 00:21:58,640
+درماتوميوسايتس أو أنواع من الأمراض تكون موجودة
+
+215
+00:21:58,640 --> 00:22:06,310
+فيها فالـ Mitosis هي الإنقسامالحقيقي وليس من
+
+216
+00:22:06,310 --> 00:22:10,950
+انتصاب المنصق المنصق، راح نحكي عنه بعد شوية ويكون
+
+217
+00:22:10,950 --> 00:22:16,870
+بهذه الطريقة، في أسئلة؟ في سؤال من الدكتورة هديل،
+
+218
+00:22:16,870 --> 00:22:23,670
+بخصوص ليش «4N»؟ لربما المقصود يعني قصد عدد اللي هو
+
+219
+00:22:23,670 --> 00:22:26,750
+اللي لها بلايد وديبلايد واشياء اللي زيها؟ أه، كمية
+
+220
+00:22:26,750 --> 00:22:36,830
+الـDNA، الأن الإنسان الطبيعيحكينا عنده 23 زوج فإذا
+
+221
+00:22:36,830 --> 00:22:42,090
+افترضنا نصهم أو كمية الـ «DNA» اللي موجودة في
+
+222
+00:22:42,090 --> 00:22:47,450
+الخلية الطبيعية في أي مرحلة بنقول عنها، نمثلها
+
+223
+00:22:47,450 --> 00:22:55,830
+أنها «2N» لأنه في نسختين فالـ الـ طبعاً نسختين،
+
+224
+00:22:55,830 --> 00:23:02,110
+نصفها من الأب ونصفها من الأمحتى يتم عملية الإنقسام
+
+225
+00:23:02,110 --> 00:23:08,510
+بدها تظهر خلية البنت أو الناتجة تماثل تمامًا
+
+226
+00:23:08,510 --> 00:23:14,570
+الخلية الأم تبعتها فحتى يتم هذا الأمر لازم في لحظة
+
+227
+00:23:14,570 --> 00:23:21,430
+معينة يتم عملية تكتير الـDNA يعني مضاعفته اللي هي
+
+228
+00:23:21,430 --> 00:23:24,890
+الـS-phase فاحنا بنكون بالـG1 phase هي الخلية
+
+229
+00:23:24,890 --> 00:23:33,370
+العادية الـDNA لما نحكي عنها46 كروموزوم DNA كامل
+
+230
+00:23:33,370 --> 00:23:38,350
+بالوصف اللي بنصفه إحنا بنكون نصف الـ DNA تبع هذه
+
+231
+00:23:38,350 --> 00:23:44,230
+المرحلة فحتى يتم عملية الإنقسام لازم بالأول يتم
+
+232
+00:23:44,230 --> 00:23:49,370
+عملية مضاعفة الـ DNA ففي الـ G2 الخلية في هذه
+
+233
+00:23:49,370 --> 00:23:54,450
+المرحلة بكون ضاعفة الـ DNA تبعتها فصار أربعة N
+
+234
+00:23:54,450 --> 00:24:01,510
+فصار عندها أربع أبعادكمية الـ DNA يعني من المفردة
+
+235
+00:24:01,510 --> 00:24:06,810
+اللي هي راح نشوف موجودة في الـ Spares والـ Eggs
+
+236
+00:24:06,810 --> 00:24:14,810
+اللي هما في الانقسام الثاني فهو نتوءًا، الـ S
+
+237
+00:24:14,810 --> 00:24:21,230
+بضاعف الـ CR4M بنقسم في الـ Mitosis بهذه الطريقة،
+
+238
+00:24:21,230 --> 00:24:27,960
+برجع توءًاهذه المصطلحات اللي بيستخدمها لكمية الـ
+
+239
+00:24:27,960 --> 00:24:34,140
+DNA اللي موجودة، واضح؟ في سؤال آخر يا دكتور بخصوص
+
+240
+00:24:34,140 --> 00:24:41,040
+الـ نعم اللي هو الـ microtubule، الشو بتفرج عن الـ
+
+241
+00:24:41,040 --> 00:24:45,360
+spindle fiber؟ هم spindle fiber هم نفسهم، هم
+
+242
+00:24:45,360 --> 00:24:50,220
+نفسهم، عبارة عن يعني بالأخير أكتين وميوسين، يعني
+
+243
+00:24:50,220 --> 00:24:57,590
+زي العضلات، إيش عشان يجد؟عشان يعني يخلّي الخلية
+
+244
+00:24:57,590 --> 00:25:04,810
+تنقسم لإن الـ DNA ينقسم ففي خيوط تبدأ من الـ
+
+245
+00:25:04,810 --> 00:25:11,630
+Centrosome على الطرف تصل لـ Centromere في نص الـ
+
+246
+00:25:11,630 --> 00:25:19,720
+Chromosome حتى تشده لطرفين، ماشي؟في برضه سؤال من
+
+247
+00:25:19,720 --> 00:25:27,020
+عمر بخصوص يعني إنه عدد الـN يعني الـA's، بقول حرف
+
+248
+00:25:27,020 --> 00:25:31,960
+الـN بيمثل عدد الـDNA و لا كمية الكرموسومات؟ كمية
+
+249
+00:25:31,960 --> 00:25:38,400
+الكرموسومات، هيك بعتبرهم على أساس نسربهم لبعض، one
+
+250
+00:25:38,400 --> 00:25:45,200
+N اللي موجود في الـspare أو في الـegg، راح ناخده
+
+251
+00:25:45,200 --> 00:25:49,520
+بعد شويةففي الخلية العادية اللي بتقوم في الشغل،
+
+252
+00:25:49,520 --> 00:25:54,600
+بكون عندى «2N»، بس بعد ما تخلص الـ «S» تدخل، بتكون
+
+253
+00:25:54,600 --> 00:25:58,560
+أنها في مرحلة «4N»، اللي هي بالـ «G2»، وبعدين
+
+254
+00:25:58,560 --> 00:26:02,940
+بتسوي عملية الإنقسام. فهو بعينك بيقول، يعني هل جيت
+
+255
+00:26:02,940 --> 00:26:08,640
+لما تصير «4N»، بيصير عدد الأزواج يعني 64 زوج؟ آه،
+
+256
+00:26:08,640 --> 00:26:12,400
+نعم، لأ، شو 64؟ لأ، مش 64، أنا استغربت من السؤال،
+
+257
+00:26:12,400 --> 00:26:17,370
+لأ، 46 زوج، صحيح؟46 زوج بدأت تضربهم بـ2 كمان يعني
+
+258
+00:26:17,370 --> 00:26:24,310
+تصير 92 زوج صحيح واضح يا طارق إن شاء الله بخصوص
+
+259
+00:26:24,310 --> 00:26:29,970
+السؤال اللي سألته الآن
+
+260
+00:26:29,970 --> 00:26:36,310
+من التجارب اللي أجرتها وكنت أسويها زمان واحنا طلاب
+
+261
+00:26:36,310 --> 00:26:40,530
+حتى إذا كان عندنا مجال نعملها اللي هو فحص بهذا
+
+262
+00:26:40,530 --> 00:26:48,740
+الشكل بنسميهالـ Karyotype الـ Karyotype إنه أول
+
+263
+00:26:48,740 --> 00:26:53,460
+شيء إحنا يعني
+
+264
+00:26:53,460 --> 00:26:58,000
+بنعطي الدواء لهو الـ Colchicine لحيث أنه يخرب الـ
+
+265
+00:26:58,000 --> 00:27:04,180
+Spindle Fibers وفي حالة ما ناخد الخلايا في مرحلة
+
+266
+00:27:04,180 --> 00:27:10,280
+يعني أنا بعطي إشي بوقف انقسام الخلاياماشي، من إنه
+
+267
+00:27:10,280 --> 00:27:13,320
+بيخرب الـ Spindle Fibers أو الـ Microtubules
+
+268
+00:27:13,320 --> 00:27:19,100
+فبتوصل الخلية مستوى الـ Metaphase اللي بيكون في
+
+269
+00:27:19,100 --> 00:27:25,980
+الـ DNA على شكل أكبر شكل مضغوط فيه فأنا بخلّي الـ
+
+270
+00:27:25,980 --> 00:27:31,040
+الـ الـ الـ الـ DNA والكرمزومات تصبح شكل مضغوط
+
+271
+00:27:31,040 --> 00:27:37,530
+وبعد ذلك كنا نوقفحتى تظبط هذا الأمر نوقف على طاولة
+
+272
+00:27:37,530 --> 00:27:43,950
+على إيش يعني بارتفاع طويل ونلقي الخلية
+
+273
+00:27:43,950 --> 00:27:50,750
+أو الساقل اللي فيه الخلايا وفي لحظة معينة بتجدوا
+
+274
+00:27:50,750 --> 00:27:56,050
+صورة مثل هذه الصورة فهذا فحص يسمى Carry Time يتم
+
+275
+00:27:56,050 --> 00:27:59,670
+صبغ الـDNA بالجِمزة
+
+276
+00:28:02,810 --> 00:28:06,790
+Stain اللي هى بيسموه الـ G-banding بهذا الشكل
+
+277
+00:28:06,790 --> 00:28:12,390
+وبنتج عندى صورة بهذا الصور بقدر من خلالها أدرس
+
+278
+00:28:12,390 --> 00:28:19,450
+خواص و أدرس الـ chromosomes والـ DNA كله بشكل كامل
+
+279
+00:28:19,450 --> 00:28:25,450
+يعني كمجموعة كاملة موجودة في الخلية فهذه عبارة عن
+
+280
+00:28:25,450 --> 00:28:30,820
+أنه أنا وقفت القسام الخلية عند مرحلةالـ Metaphase
+
+281
+00:28:30,820 --> 00:28:37,700
+وبكون الـ DNA بأكبر شكل مضغوط فيه وبستخدم صبغة
+
+282
+00:28:37,700 --> 00:28:41,840
+وبحاول أزيدها بحيث تتناثر الـ Chromosomes شوية
+
+283
+00:28:41,840 --> 00:28:47,040
+بعيد عن بعض عايز أشوفها ولمّا أشوف الصورة هذه اللي
+
+284
+00:28:47,040 --> 00:28:52,320
+هي هذه بتكون مطبوعة على ورقة بجيب مقص و بقص الـ
+
+285
+00:28:52,320 --> 00:28:58,980
+Chromosomes و برتبها بهذا الشكلفأحيانًا، يعني كل
+
+286
+00:28:58,980 --> 00:29:02,900
+إثنين من الكرموزومات لازم يكونوا متشابهات وبدها
+
+287
+00:29:02,900 --> 00:29:10,660
+تخيل إن الإشي محطوط بشكل مظبوط فالـ «روموزومات»
+
+288
+00:29:10,660 --> 00:29:17,600
+واحد الـPairs اللي هم الـ22 وهنا ذكر الـXY
+
+289
+00:29:17,600 --> 00:29:24,800
+كرموزومات وبكون شكلهم بهذا الشكلفهذه تجربة أنا
+
+290
+00:29:24,800 --> 00:29:30,000
+كطالب طب كنا في الكويت سويتها وعملتها بيدي إني
+
+291
+00:29:30,000 --> 00:29:36,700
+أشوف وهذا يعني إذا بدكم إياها تفق مع مختبر اللي هو
+
+292
+00:29:36,700 --> 00:29:40,560
+بيسوي عملية فحص الجينات عن طريق بيقولوله فحص الـ
+
+293
+00:29:40,560 --> 00:29:45,840
+Karyotype هنا لا نستطيع يعني التكلم عن
+
+294
+00:29:45,840 --> 00:29:50,590
+الـIndividual Genesأحنا هنا نقدر مثلًا زي ما
+
+295
+00:29:50,590 --> 00:29:54,750
+تعرفوا تسمعوا «Down Syndrome» «Trisomy 21» إنه
+
+296
+00:29:54,750 --> 00:29:59,010
+بيكون بدل ما عندي مثلًا كروموزوم 21 بدل ما هم
+
+297
+00:29:59,010 --> 00:30:07,470
+اثنين، pair، بيكون عندي خلافة أو XXY مثلًا أو
+
+298
+00:30:07,470 --> 00:30:10,670
+«Trisomy» يعني راح نحكي على الكروموزوم
+
+299
+00:30:10,670 --> 00:30:14,090
+الـAnomalies وهدولة بيكونوا من خلال هذا الفحص اللي
+
+300
+00:30:14,090 --> 00:30:20,290
+بتسميه «Karyotype»فهذا أحد الفيقوسات وهذه هنا بهذا
+
+301
+00:30:20,290 --> 00:30:27,090
+الشكل هي Metaphase في الـ Mitosis بتكون يعني في
+
+302
+00:30:27,090 --> 00:30:31,750
+لحظة ما بتكون الـ DNA Condensed وهذه بتكون، شو
+
+303
+00:30:31,750 --> 00:30:37,470
+اسمها؟ بتكون يعني لدراسة الكرمозومات الموجودة والـ
+
+304
+00:30:37,470 --> 00:30:42,750
+G-banding يعني هو اللي نستفيد منه حتى أحيانًا في
+
+305
+00:30:42,750 --> 00:30:50,330
+وصفسواء الحالات أو وين الواحد يبحث أو شوه الأشياء
+
+306
+00:30:50,330 --> 00:30:54,670
+اللي بتكون موجودة يعني دايماً إحنا لما نرسم الـDNA
+
+307
+00:30:54,670 --> 00:31:00,750
+أو الـChromosome برسموه بهذا الشكل وعليه نطاقات،
+
+308
+00:31:00,750 --> 00:31:04,990
+عليه إشي أغمق، أفتح، كده، هذه بتساعد في عملية
+
+309
+00:31:04,990 --> 00:31:09,770
+الوصف وعملية التعامل
+
+310
+00:31:09,770 --> 00:31:14,490
+مع الـChromosome، في سؤال؟في سؤالة، يا دكتور،
+
+311
+00:31:14,490 --> 00:31:18,210
+بخصوص المادة، يعني الدكتورة أسمها بتسأل المادة
+
+312
+00:31:18,210 --> 00:31:20,830
+اللي بتوقف عملية الـmetaphase أو المقصر،
+
+313
+00:31:20,830 --> 00:31:24,210
+الـColchicine، أه الـColchicine، حكيتها، مخرب
+
+314
+00:31:24,210 --> 00:31:28,250
+الـSpindelfiber أو الـMicrotubules دولة، هذا
+
+315
+00:31:28,250 --> 00:31:31,730
+الـmechanism of action، يعتبر الـmain mechanism of
+
+316
+00:31:31,730 --> 00:31:35,510
+action، وده يستخدم شكل كبير، طبعاً الجرع بدأ تكون
+
+317
+00:31:35,510 --> 00:31:42,780
+مختلفة وبتحطوه على الـشو بيسموها، يعني الـالـ Cell
+
+318
+00:31:42,780 --> 00:31:48,260
+Culture يعني في الـ Environment تبع الخلية، فأه،
+
+319
+00:31:48,260 --> 00:31:53,180
+ماشي، يعني هذه تجربة بتسمى عملية الـ Karyotype
+
+320
+00:31:53,180 --> 00:31:59,020
+وهيك بتكون نتيجتها، بتكون إنها تظهر الكروموزومات
+
+321
+00:31:59,020 --> 00:32:04,960
+بشكل مضغوط ويتم صبغها بحيث تظهر فيها النطاقات أو
+
+322
+00:32:04,960 --> 00:32:09,860
+الـ Binding هذا، وهيستفاد منها في عملية دراسة
+
+323
+00:32:10,230 --> 00:32:15,130
+بالذات الأمراض الكروموزومية أو ما دون الكروموزوم
+
+324
+00:32:15,130 --> 00:32:20,650
+بس مش لجين واحد لأنه بالمتوسط كل كروموزوم فيه
+
+325
+00:32:20,650 --> 00:32:25,650
+حوالي ألف جين يعني عدد كبير من الجينة فبالتالي
+
+326
+00:32:25,650 --> 00:32:30,730
+يعني ما بتفيد لإيش دقيق إنما هيك بيكون لظاهرة
+
+327
+00:32:30,730 --> 00:32:34,970
+كبيرة كتير زي الـChromosomal Anomalies فاحنا بقعد
+
+328
+00:32:34,970 --> 00:32:35,830
+عنهم بعد شوية
+
+329
+00:32:38,690 --> 00:32:43,950
+فالـ … الـ إحنا يعني اللي بدنا نـ … يعني من
+
+330
+00:32:43,950 --> 00:32:51,130
+الظواهر نتكلم عنها إنه في حالة، في مرحلة معينة الـ
+
+331
+00:32:51,130 --> 00:32:58,790
+interface اللي بيكون فيه داخل الخلية بيكون هناك
+
+332
+00:32:58,790 --> 00:33:05,670
+جدار نواء وهناك يكون الـ DNA على شكل خط ثالث
+
+333
+00:33:06,370 --> 00:33:11,770
+فبالتالي خيط يعني حتى يتم نسخه لو تكوين
+
+334
+00:33:11,770 --> 00:33:18,630
+الـChromosomes فيه آسف ونسخه عمل الـRNA وتكوين
+
+335
+00:33:18,630 --> 00:33:23,130
+البروتينات منه بيكون ما يسمى Decondensed يعني
+
+336
+00:33:23,130 --> 00:33:30,750
+بيكون مش مضغوطفلما نبدأ في عملية الـ Mitosis لازم
+
+337
+00:33:30,750 --> 00:33:37,770
+هذا الـ DNA يتم لفه وربطه بشكل مضغوط جداً جداً في
+
+338
+00:33:37,770 --> 00:33:42,250
+الـ Prophase ويهيئه لعملية الـ Metaphase لما نوقف
+
+339
+00:33:42,250 --> 00:33:47,670
+بالنص ويتم فصله فدايماً في كل عملية انقسام خلية
+
+340
+00:33:48,660 --> 00:33:54,100
+الخيط الـ «DNA» اللي هو كان أصل خيط فالد طويل جداً
+
+341
+00:33:54,100 --> 00:34:02,040
+بتم لفه في ربطة يعني زي ضمة إحبال ملفوفة بشكل شديد
+
+342
+00:34:02,040 --> 00:34:07,080
+بحيث تقريباً تصبح جسم صلب أو جسم منفصي بحيث يتم
+
+343
+00:34:07,080 --> 00:34:12,640
+فصله لنسختين وبعدين يتم فكه مرة ثانية الـProphase
+
+344
+00:34:12,640 --> 00:34:17,040
+والـMetaphase بيكونش فيه غشاء نوع، بنشعل، وبعدين
+
+345
+00:34:17,040 --> 00:34:22,080
+برجع مرة ثانيةفهذه كلها ظواهر بتكون موجودة ولازم
+
+346
+00:34:22,080 --> 00:34:28,800
+واحد ينتبهها الـ… الـChromosome replication في
+
+347
+00:34:28,800 --> 00:34:34,860
+حالة اللي حكينا 4N، كيف بيكون؟ إذا افترضنا إنه
+
+348
+00:34:34,860 --> 00:34:42,380
+الـ… أنا بالأول كان عندي كرموزوم بهذا الشكل الـ…
+
+349
+00:34:42,380 --> 00:34:50,510
+الـ… الـN هنابدنا نتكلم، يعني ندخل على قضية
+
+350
+00:34:50,510 --> 00:34:55,110
+الانقسام المنصر اللي هو الـ Meiosis اللي هو بتتم
+
+351
+00:34:55,110 --> 00:35:04,510
+فيه بتكوين اللي هما الـSperm والـEgg
+
+352
+00:35:05,150 --> 00:35:10,570
+أيوة يا رُباط، احكوا في سؤال يا دكتور، يعني قبل ما
+
+353
+00:35:10,570 --> 00:35:13,430
+تسأل دكتور رُباط، في سؤال من دكتورة جمانة تقول
+
+354
+00:35:13,430 --> 00:35:19,470
+عملية النسخ بتصير في الـInterface، بس؟ لأ، بالـS،
+
+355
+00:35:19,470 --> 00:35:27,630
+النسخ هاي، اللي هي هنا يعني حتى لما نيجي بهذه
+
+356
+00:35:27,630 --> 00:35:35,450
+الظاهرة، ماشي، النسخ بتتم في هذه اللحظةاللي هي
+
+357
+00:35:35,450 --> 00:35:40,110
+بتكون الخلية بدأت في الـG1 بتكون شغالة أمان الله
+
+358
+00:35:40,110 --> 00:35:45,830
+بتقرر أو بتجيها أمر أو دافع إنها بدأت تنقسم أو
+
+359
+00:35:45,830 --> 00:35:51,270
+بحاجة تنقسم أول شي بتعمله بتضاعف كمية الـDNA
+
+360
+00:35:51,270 --> 00:35:56,570
+تبعتها ترتاحلها شوية بالـG2 phase وبعدين تبدأ تدخل
+
+361
+00:35:56,570 --> 00:36:01,350
+في الـmitosis اللي هي عملية الإنقسام فالانقسام من
+
+362
+00:36:01,350 --> 00:36:07,980
+2N ل4N بتتمفي الـ S-Phase وهنا أعطيكم إذا افترضنا
+
+363
+00:36:07,980 --> 00:36:14,700
+الخلية انقسمت خلال 24 ساعة مرة بتكون في الـG1 مثلا
+
+364
+00:36:14,700 --> 00:36:19,360
+نص النهار وبعدين بدها 6 ساعات أو آسف يعني انت
+
+365
+00:36:19,360 --> 00:36:26,280
+قريبا 12 ساعة ثانيات عشان تنقسم بالأول بتضاعف
+
+366
+00:36:26,280 --> 00:36:31,280
+الـDNA اللي هي الـS-Phase وبعدين بترتاح شويه
+
+367
+00:36:31,280 --> 00:36:36,340
+بالـG2يعني بتجهز على لإنها تبدأ الـ Mitosis،
+
+368
+00:36:36,340 --> 00:36:40,560
+وبعدين بتصوّر الـ Mitosis الـ Mitosis هذا، اللي هو
+
+369
+00:36:40,560 --> 00:36:46,640
+إنه بتكون Centrosomes وبصير الـ DNA والـ
+
+370
+00:36:46,640 --> 00:36:51,680
+Chromosomes هيك تتبين و تـ Condense، وبعدين الـ
+
+371
+00:36:51,680 --> 00:36:56,200
+Brometaphase بتبدأ يكون Spindle Fiber وبختفي الـ
+
+372
+00:36:56,200 --> 00:37:01,100
+Nuclear Membrane، وبعدين بالـ Metaphase بتصف بهذا
+
+373
+00:37:01,100 --> 00:37:06,270
+الشكلوبعدين بيتم جرّة DNA للطرفين وبعدين القسق
+
+374
+00:37:06,270 --> 00:37:11,350
+الخلية بتنتصف فده بترجع تكوّن الـ Nuclear Membrane
+
+375
+00:37:11,350 --> 00:37:19,090
+وبيفك الـ DNA وبيصير Uncondensed واضح؟ روبة؟ بدها
+
+376
+00:37:19,090 --> 00:37:24,470
+أي شيء؟ يبدو أنه ما عندها سؤال أو لم إجابة السؤال
+
+377
+00:37:24,470 --> 00:37:31,430
+بالنسبة للظاهرة الأخرى اللي هي عمليةالـ Meiosis
+
+378
+00:37:31,430 --> 00:37:36,930
+اللي هو الانقسام المنصف اللي هو إنه بنتج في الجميز
+
+379
+00:37:36,930 --> 00:37:44,390
+اللي هما الـ Sperm والـ Egg تبدأ
+
+380
+00:37:44,390 --> 00:37:50,930
+أيضًا يعني بتكون الـ Resting Cell أو الخلية
+
+381
+00:37:50,930 --> 00:37:57,750
+الأصلية بتكون عندنا كمية DNA معينة، ماشي نبدأ إنه
+
+382
+00:37:57,750 --> 00:38:04,680
+أول شيء الـ DNA بتضعفوبعدين بتنقسم على مرحلتين
+
+383
+00:38:04,680 --> 00:38:11,980
+المرحل الأولى بتصير كروموزوم واحد في كل جهة وبعدين
+
+384
+00:38:11,980 --> 00:38:17,640
+بنقسم نص الكروموزوم اللي هي الـHafloid Gametes
+
+385
+00:38:17,640 --> 00:38:25,180
+يعني بالأخير بكون 2N بوصل 4N بعطينا أربعة 1N
+
+386
+00:38:25,180 --> 00:38:32,280
+Gametes أو اللي هي Sperm أو Fertilizedفهذه خطوات
+
+387
+00:38:32,280 --> 00:38:38,100
+الـ Meiosis يعني بالأخير على مرحلتين ونتيجته إن
+
+388
+00:38:38,100 --> 00:38:43,320
+كمية الـ DNA بدأت تكون نص الكمية اللي هي 1N لأنه
+
+389
+00:38:43,320 --> 00:38:48,360
+بالكالية العادية بتكون 2N فالأمر
+
+390
+00:38:48,360 --> 00:38:55,080
+بتتم من خلال مرحلتين بتسميهم Meiosis I اللي هي
+
+391
+00:38:55,080 --> 00:39:00,120
+بهذا الشكل بتبدأ بـ Interphase بعدين بتروح لـ
+
+392
+00:39:00,120 --> 00:39:06,790
+Prophaseوبعدين متى phase one وانا phase one بحيث
+
+393
+00:39:06,790 --> 00:39:14,830
+انه بعطيني يعني اللي هما two يعني حسب راح ناخدهم
+
+394
+00:39:14,830 --> 00:39:20,530
+حسب الـ «وين» هل هي male ولا female بحيث بعطيني
+
+395
+00:39:20,530 --> 00:39:28,040
+الأخير الجامعي بدخل بعدين enter phase twoميتا فايز
+
+396
+00:39:28,040 --> 00:39:32,760
+تُو وأنا فايز تُو لقاد ما يعطينا الجامعات فهذه
+
+397
+00:39:32,760 --> 00:39:39,140
+خطوات الإنقسام المنصر بالترتيب هذا، interface،
+
+398
+00:39:39,140 --> 00:39:44,040
+بعدين، أيه أخدنا هنا Pro phase وميتا Pro phase،
+
+399
+00:39:44,040 --> 00:39:45,740
+وميتا Pro phase، وميتا Pro phase، وميتا Pro phase،
+
+400
+00:39:45,740 --> 00:39:45,740
+وميتا Pro phase، وميتا Pro phase، وميتا Pro phase،
+
+401
+00:39:45,740 --> 00:39:45,900
+وميتا Pro phase، وميتا Pro phase، وميتا Pro phase،
+
+402
+00:39:45,900 --> 00:39:46,340
+وميتا Pro phase، وميتا Pro phase، وميتا Pro phase،
+
+403
+00:39:46,340 --> 00:39:46,340
+وميتا Pro phase، وميتا Pro phase، وميتا Pro phase،
+
+404
+00:39:46,340 --> 00:39:46,340
+وميتا Pro phase، وميتا Pro phase، وميتا Pro phase،
+
+405
+00:39:46,340 --> 00:39:48,360
+وميتا Pro phase، وميتا Pro phase، وميتا Pro phase،
+
+406
+00:39:48,360 --> 00:39:52,490
+وميتالـ Metaphase يعني عشان نتذكر لما نكون الـ
+
+407
+00:39:52,490 --> 00:39:55,750
+«كروموزوماتيك» مصففة بالنص وفيه عندي Two
+
+408
+00:39:55,750 --> 00:39:59,050
+Centrosomes وفيه عندي Spindle Fiber، هاي الـ
+
+409
+00:39:59,050 --> 00:40:02,370
+Metaphase وبعدها بتصير عملية الشد اللي يسميه
+
+410
+00:40:02,370 --> 00:40:06,130
+Anaphase فالنقطة
+
+411
+00:40:06,130 --> 00:40:14,070
+هنا في أي انقسام ماشي بالذات
+
+412
+00:40:14,070 --> 00:40:22,480
+يعني هنافي حالة اللي حكينا عنه الـ Meiosis اللي هو
+
+413
+00:40:22,480 --> 00:40:29,240
+الانقسام المنصر الـ Mitosis نفس الـ Chromosome
+
+414
+00:40:29,240 --> 00:40:34,500
+بيكون عنده من الـ Centromere تبعه بنفصلنا نصين
+
+415
+00:40:34,500 --> 00:40:43,020
+بيكونوا متشابهات إذا تخيلنا أنا عندي سلكين كتوال
+
+416
+00:40:43,020 --> 00:40:48,940
+أو لفتينحبل، ملفوفات وأنا باجي بحطهم مقبال بعض
+
+417
+00:40:48,940 --> 00:40:54,600
+وباجي بفصلهم إلا أحيانًا بيحدث إنه Recombination
+
+418
+00:40:54,600 --> 00:41:02,940
+يعني اللي هي إن الـ «DNA» يعني هناك آليات لقطع أو
+
+419
+00:41:02,940 --> 00:41:08,200
+إذا صار قطع إنه يصير عملية وصل مرة ثانية للقطع
+
+420
+00:41:08,200 --> 00:41:14,370
+فإذا أحيانًا حبلين أو سلكين التفن على بعضعشان
+
+421
+00:41:14,370 --> 00:41:20,490
+نفكهم مظبوط بتم عملية قطع وصل بحيث أنه أحيانًا بتم
+
+422
+00:41:20,490 --> 00:41:26,410
+عملية نقل المادة الوراثية من فرق إلى فرق آخر أو من
+
+423
+00:41:26,410 --> 00:41:31,570
+جهة إلى جهة أخرى أحيانًا نتيجة الـHomologous
+
+424
+00:41:31,570 --> 00:41:36,430
+Recombination الـMyosis Homologous يعني متساوي أو
+
+425
+00:41:36,430 --> 00:41:45,110
+متكافئ، ماشي؟ هنا بمعنى إنهاللي صار إنه القطع اللي
+
+426
+00:41:45,110 --> 00:41:49,530
+طارت من هون مشابه للقطع اللي طارت لهذه الجهة
+
+427
+00:41:49,530 --> 00:41:55,990
+الأخرى فهنا إذا ابتدينا بيعني هذا الـChromosome
+
+428
+00:41:55,990 --> 00:42:00,410
+اللي أخدته من والدي وهذا من والدتيوكانوا في حالة
+
+429
+00:42:00,410 --> 00:42:07,770
+الـ Meiosis وقفوا قبال بعض هذا الـGene، يعني مثلًا
+
+430
+00:42:07,770 --> 00:42:15,050
+نخد وصفة وفصيلة الدم الـHLA-type، وفصيلة كدا، أي
+
+431
+00:42:15,050 --> 00:42:20,070
+شيء بعد ما كان على كرموزوم معين ممكن تنتقل إلى
+
+432
+00:42:20,070 --> 00:42:26,030
+الكرموزوم الثاني والسبب أننا نتعامل مع خيط كان
+
+433
+00:42:26,030 --> 00:42:32,250
+الأصل فارد وطويللفناها، بس أحيانًا مع الالتفاف هذا
+
+434
+00:42:32,250 --> 00:42:36,690
+وتوقيفهم جانب بعض بيصير عملية أحيانًا انتقال
+
+435
+00:42:36,690 --> 00:42:41,450
+فأحيانًا الانتقال مش متساوي بتروح هنا قطعة تطلع
+
+436
+00:42:41,450 --> 00:42:45,230
+كبيرة وهنا تطلع قطعة صغيرة بس أحيانًا ممكن نكون
+
+437
+00:42:45,230 --> 00:42:52,550
+متكافئ تمامًا لأنه مظهريًا بالخارق الأخير القطعتين
+
+438
+00:42:52,550 --> 00:42:59,660
+متساويات في الحجمفي الـ «أندرذاكر» في الخصية
+
+439
+00:42:59,660 --> 00:43:07,180
+«Testis»، في «Spermatogoa»، بتمر بالـ «Meiosis I»
+
+440
+00:43:07,590 --> 00:43:13,370
+فـPrimary هون «Spermatogonium» لـ«Primary
+
+441
+00:43:13,370 --> 00:43:18,610
+Spermatocyte» و«Secondary Spermatocytes» بعدين
+
+442
+00:43:18,610 --> 00:43:23,210
+بدخل إشي بنسميه «Spermatids» لحد ما يعطينا
+
+443
+00:43:23,210 --> 00:43:33,610
+«Sperms» كان هنا الخلية «XY» يعني بتكون «2N» دخلت
+
+444
+00:43:33,610 --> 00:43:39,930
+بـ«4N» عطتنا «2N» لكل واحدةبس بعدين لما تنقسم من
+
+445
+00:43:39,930 --> 00:43:46,530
+القسام الثاني بتصير one M في كل صفير I عند الذكر
+
+446
+00:43:46,530 --> 00:43:52,250
+في القصير في المبيض عند الأنثى الـ ovary primary
+
+447
+00:43:52,250 --> 00:43:58,510
+of a side بتظلها خاملة لحد عند البلوغ وبعدين لما
+
+448
+00:43:58,510 --> 00:44:04,610
+تبدأ التورة بتصير أنSecondary Oocyte وMyotic
+
+449
+00:44:04,610 --> 00:44:10,590
+Spindle وFirst Polar Body بتاخد عنهم بعدين بحيث
+
+450
+00:44:10,590 --> 00:44:17,110
+أنه بتكون عندي الـ يعني هنا الـ Meiosis I اللي أنا
+
+451
+00:44:17,110 --> 00:44:22,110
+بتذكرها بحيث هنا الـ Meiosis II بحيث أنه ينتج عندي
+
+452
+00:44:22,110 --> 00:44:29,030
+بيضة واحدة بالنسبة لإذا مقارنتها بالذكر يعني هنا
+
+453
+00:44:29,030 --> 00:44:37,120
+كان2N مرحلة صار 4N وبالـ Meiosis 1 انتهى لـ2N
+
+454
+00:44:37,120 --> 00:44:44,720
+وMeiosis 2 صار 1N ان نتخيل انه في الأنثى الـ
+
+455
+00:44:44,720 --> 00:44:52,780
+Female بعد ما أصبح عندي 4N هذا الجزء تحول إلى ما
+
+456
+00:44:52,780 --> 00:44:58,570
+يسمونه Polar Body يعني خلية ميتة لأنهيعني في
+
+457
+00:44:58,570 --> 00:45:03,710
+الأنثى المطلوب بويضة واحدة فقط فما في داعي نكون
+
+458
+00:45:03,710 --> 00:45:09,530
+بويضات كثير فالـ الـ الـ الـ لما تمشي بالطريق راح
+
+459
+00:45:09,530 --> 00:45:13,590
+تمشي كأنه بطريق في هذا الشكل واحد فبما أنه
+
+460
+00:45:13,590 --> 00:45:17,950
+انقسامين، الانقسام الأول بيعطينا اسمه الـ First
+
+461
+00:45:17,950 --> 00:45:22,210
+Polar Body فهذا طبعا ما بتكونه، و بعدين لما تنقسم
+
+462
+00:45:22,210 --> 00:45:25,690
+من Two End لOne End برضه بتعطينا Polar Body ثاني
+
+463
+00:45:26,090 --> 00:45:31,870
+فزي ما هم شايفين هنا، بيحطوا إنه الـFertilized Egg
+
+464
+00:45:31,870 --> 00:45:36,810
+أو قبل الـFertilization، بدي يكون الـFirst Boiler
+
+465
+00:45:36,810 --> 00:45:41,130
+Body وبعدين الـSecond Boiler Body اللي هم يعني،
+
+466
+00:45:41,130 --> 00:45:46,370
+لأن الأنثى، احنا بحاجة عادة في كل دورة لخلية واحدة
+
+467
+00:45:46,370 --> 00:45:51,450
+بس فقط، بيضة واحدة، فهذه كلها دواهر بتصيروبعدين
+
+468
+00:45:51,450 --> 00:45:55,630
+بيصير عملية الـ Fertilization وبترجع بتكون الإنسان
+
+469
+00:45:55,630 --> 00:46:02,610
+من 2N وFertilized egg فهذه باقية الـ أو الظواهر
+
+470
+00:46:02,610 --> 00:46:09,170
+اللي بتصير في اللي بنسميه الـ Meiosis الـ Meiosis
+
+471
+00:46:09,170 --> 00:46:13,490
+اللي هو الإبتسام المنصق اللي بنتجه إنه الـ Eggs
+
+472
+00:46:13,490 --> 00:46:19,810
+والـ Sperms وبكون النتيجة إنه راح يكون عندنا 1N of
+
+473
+00:46:19,810 --> 00:46:26,700
+DNAبيكون موجود في الخلية هذه؟ في أسئلة؟ فيها دكتور
+
+474
+00:46:26,700 --> 00:46:30,540
+سؤال من دكتور معتز بخصوص عملية الـRecombination
+
+475
+00:46:30,540 --> 00:46:37,240
+نعم بيسأل هل لها تأثير؟ طبعاً لها تأثير كبير، يعني
+
+476
+00:46:37,240 --> 00:46:43,580
+في ظواهر كثيرة راح نحكي شوفوا، الأهمية اللي بنحكي
+
+477
+00:46:43,580 --> 00:46:51,270
+اللي هو حتى يفسر الواحد الأمراضوالحالات وكيف
+
+478
+00:46:51,270 --> 00:46:56,770
+الإنسان بتكون وأسباب ليش تمشي الأمور بهذا الشكل
+
+479
+00:46:56,770 --> 00:46:59,950
+يعني
+
+480
+00:46:59,950 --> 00:47:06,230
+إذا تخيلنا قضية إنه لو افترضنا إنه كل البشر
+
+481
+00:47:06,230 --> 00:47:12,490
+متشابهين تمامًا ماشي كان لو أتى أي مرض أو أي حالة
+
+482
+00:47:12,490 --> 00:47:21,110
+أو أي عدو بتلاقينا كلنا راحنتأثر بشكل شديد ولكن
+
+483
+00:47:21,110 --> 00:47:26,170
+يعني وقائة للبشرية
+
+484
+00:47:26,170 --> 00:47:29,690
+كلها ربنا حاط فينا إنه فيه اختلافات بيننا
+
+485
+00:47:29,690 --> 00:47:37,650
+والاختلافات بيظلها متكررة ومافيش تقريبًا لإثنين
+
+486
+00:47:37,650 --> 00:47:44,390
+بشر متشابهين تمامًا حتى لو يعني أقارب يعني راح
+
+487
+00:47:44,390 --> 00:47:49,000
+نحكي عن ظواهر بالتمعلى كروموزوم مش كروموزوم ثاني،
+
+488
+00:47:49,000 --> 00:47:53,600
+يعني تستنى على هذه المواضيع، أه، إلها همية كبيرة،
+
+489
+00:47:53,600 --> 00:47:59,680
+Recombination، وبتتدخل يعني في جوانب كثيرة، نعم،
+
+490
+00:47:59,680 --> 00:48:03,520
+في أسئلة أخرى؟ في سؤال من الدكتور، الدكتور
+
+491
+00:48:03,520 --> 00:48:09,060
+أويجدان، بخصوص الـPolar Body، أيش المقصود فيها؟
+
+492
+00:48:09,060 --> 00:48:16,110
+لما تسير عملية الإنقسام المنصف، ماشي،الانقسام
+
+493
+00:48:16,110 --> 00:48:24,870
+المنصف الذكر أنا بدي الأربع «Sperms» الـ «Sperms»
+
+494
+00:48:24,870 --> 00:48:32,090
+يعني الذكر بيكون عنده ملايين الحيوانات المنوية
+
+495
+00:48:32,090 --> 00:48:36,110
+وتتسابق اللي يخفي يكون أفضل واحد فيها اللي يصل
+
+496
+00:48:36,110 --> 00:48:42,310
+اللي يلقح البويضة عند الأنثة المطلوب أن تكون بويضة
+
+497
+00:48:42,310 --> 00:48:50,530
+واحدة فقطفإذا تخيلتي يعني كانت الغالية بدأت بالـ
+
+498
+00:48:50,530 --> 00:48:57,610
+Meiosis I وبتكون قبلها وصلت زي ما ذكرنا من قبل إنه
+
+499
+00:48:57,610 --> 00:49:05,090
+أعطت سوّت S phase وعملت 4N فلما تنقسم الإنقسام
+
+500
+00:49:05,090 --> 00:49:10,270
+الأول واحدة من البيتين اللي أحسن أو اللي راح تكون
+
+501
+00:49:10,270 --> 00:49:16,710
+بيضة أحسنهي اللي بتكمل والثانية يتم يعني تجميدها
+
+502
+00:49:16,710 --> 00:49:24,850
+ويتم يعني ديش أقول قضاء عليها بيظل إنه في داخل
+
+503
+00:49:24,850 --> 00:49:32,930
+تركيب الـ Boiler في المبيض الأنثى بنلاقي هيك نواة
+
+504
+00:49:32,930 --> 00:49:40,800
+يعني مضغوطة بشكل بيسموه Polar Bodyبكون هو الخلية
+
+505
+00:49:40,800 --> 00:49:46,100
+الثانية اللي يتم تخلص منها بهذا الطريق فمع
+
+506
+00:49:46,100 --> 00:49:49,860
+الإنقسام الأول، بتتم تكوين الـFirst Polar Body
+
+507
+00:49:49,860 --> 00:49:54,320
+كمية الـDNA اللي فيه بدي تكون 2N زي اللي جنبها
+
+508
+00:49:54,320 --> 00:50:01,900
+التانية لما تنقسم بالمياثيس 2 وتعطينا 1N DNA برضه
+
+509
+00:50:01,900 --> 00:50:08,340
+بتكون Polar Body ثاني، بيكون فيه 1N DNAوبكون اثنين
+
+510
+00:50:08,340 --> 00:50:12,200
+موجودات، لأنه أنا عندى انقسامين وفي حالة البويضة
+
+511
+00:50:12,200 --> 00:50:16,940
+أنا مابدى غير بويضة واحد، بس، ماشي، فعشان هيك
+
+512
+00:50:16,940 --> 00:50:25,200
+طريقتها مختلفة وهذا الـPolar Body هو تمثيل أو بقية
+
+513
+00:50:25,200 --> 00:50:33,260
+الخلية اللي كانت في الانقسام اللي لم تكمل الطريق
+
+514
+00:50:33,260 --> 00:50:37,070
+ولم يُكتب لها إنها تكمل الطريق، بحيث إنهبكون عندى
+
+515
+00:50:37,070 --> 00:50:41,050
+بوايضة واحدة يعني هي عشان ننتج بوايضة واحدة من
+
+516
+00:50:41,050 --> 00:50:48,230
+الخلية الأصلية اللى هى كانت صارت 4N بعد ما كانت 2N
+
+517
+00:50:48,230 --> 00:50:54,730
+اللى هى بداية ما يوصف، واضح؟
+
+518
+00:50:54,730 --> 00:51:06,150
+فيه أسلة؟ هيك احنا بنكون خلصنا دواهر الفصل الثانى
+
+519
+00:51:06,340 --> 00:51:12,700
+أه، في حد عنده سؤال؟ لحد الآن تمام يا دكتور أيه؟
+
+520
+00:51:12,700 --> 00:51:18,720
+نبدأ الآن بمحاضرة اليوم في سؤال من أحمد يعني يعني
+
+521
+00:51:18,720 --> 00:51:23,000
+هو سؤال ربما يعني لسه بدري عليه كيف بتصير التوائم
+
+522
+00:51:23,000 --> 00:51:29,040
+الغير متطابقة؟ أه، شوف التوائم الغير متطابقة
+
+523
+00:51:29,040 --> 00:51:38,830
+أحيانا بتنتج Boy-The-Tailيعني ويدتين بتكونوا و
+
+524
+00:51:38,830 --> 00:51:49,150
+أحياناً يعني بتتم عملية تخصيبهم بحيوانين منويين
+
+525
+00:51:49,150 --> 00:51:55,070
+اتنين أحياناً يعني الطواقم المتطابقة إنه بعد ما
+
+526
+00:51:55,070 --> 00:52:01,750
+خلية واحدة تكون ملقحة تنقسم إلى خليتين يُعاملوا
+
+527
+00:52:01,750 --> 00:52:06,580
+على إنهمبتطلب من الجسم واحد وبنقسمه لجسمين
+
+528
+00:52:06,580 --> 00:52:14,540
+وبالتالي بيصبحوا خليتين فيه دراسات حدثت بالتاريخ
+
+529
+00:52:14,540 --> 00:52:20,680
+وموجودة يعني إنه إمرأة بتطلع بوايدتين ويتم تلقيحهم
+
+530
+00:52:20,680 --> 00:52:24,880
+بحيوانات منوية من شخصين مختلفين، تخيل يعني شو صار
+
+531
+00:52:24,880 --> 00:52:29,820
+بالحالة هذه يعني، بس هاي شيء موجود في دراسة
+
+532
+00:52:29,820 --> 00:52:35,340
+الكروموزوماتالبشر والأشياء العجيبة غريبة يعني فهي
+
+533
+00:52:35,340 --> 00:52:41,160
+كلها ظواهر ممكنة وإن شاء الله سنتكلم بشكل أدق كيف
+
+534
+00:52:41,160 --> 00:52:46,030
+يتم دراسة في هذا الموضوعالآن دائماً حتى يفهم
+
+535
+00:52:46,030 --> 00:52:51,170
+الواحد شو اللي بيصير بدي أكون عنده آليات للدراسة
+
+536
+00:52:51,170 --> 00:52:56,290
+ماكروسكوبات معينة حتى أشوف شو اللي بيصير فعلى
+
+537
+00:52:56,290 --> 00:53:02,630
+استخدام الأجهزة والـ والفهم كيف يدرس هذا الموضوع
+
+538
+00:53:02,630 --> 00:53:07,710
+ممكن الواحد يعني يفهمها بشكل أفضل يعني فهي كما
+
+539
+00:53:07,710 --> 00:53:11,450
+ذكرت يعني راح ناخدها بشكل أدق يعني، ماشي؟
+
+540
+00:53:14,610 --> 00:53:20,110
+المحاضرة اليوم راح نبدأ بالـ «Human Genome والجين
+
+541
+00:53:20,110 --> 00:53:27,730
+Structure and Function» يعني نفهم كيف الـ «DNA»
+
+542
+00:53:27,730 --> 00:53:31,970
+المادة هذه اللي موجودة في النواة اللي موجودة في كل
+
+543
+00:53:31,970 --> 00:53:39,910
+الخلايا زي بعض اللي هي فيها الشيفرة الوراثية اللي
+
+544
+00:53:39,910 --> 00:53:46,130
+فيهاالمحدد لكيف مظهر الإنسان راح يكون بيعطينا
+
+545
+00:53:46,130 --> 00:53:51,990
+المظهر اللي إحنا بنشوفه بالاخير فإحنا
+
+546
+00:53:51,990 --> 00:54:04,270
+عندما نتكلم عن الإنسان كـ يعني كمخلوق أو ككائن حي
+
+547
+00:54:04,270 --> 00:54:14,250
+أو organism، ماشي لما نيجي ندرسهندرس طريقة تركيبه
+
+548
+00:54:14,250 --> 00:54:19,870
+من خلال الفهم التشريح وظائف الأعضاء والسلوكيات
+
+549
+00:54:19,870 --> 00:54:27,010
+ويعني الكيمويات تبعته والأشياء هذه لما ندرس حتى
+
+550
+00:54:27,010 --> 00:54:31,330
+تركيب هذه الترتيب
+
+551
+00:54:31,330 --> 00:54:37,630
+هذه المظاهر الكبيرة نجد أنها بالأخير يعني وحدة
+
+552
+00:54:37,630 --> 00:54:44,280
+بناء الإنسان هي من الخلايافتفاعل الخلايا وتأثر
+
+553
+00:54:44,280 --> 00:54:48,940
+الخلايا ووظيفة الخلايا وتفاعل الخلايا مع بعض هو ما
+
+554
+00:54:48,940 --> 00:54:54,980
+يعطينا المظهر الخارجي بالنهاية ففي
+
+555
+00:54:54,980 --> 00:55:00,740
+كل جوانب وظائف الخلايا تجد أنها تعتمد على
+
+556
+00:55:00,740 --> 00:55:05,380
+البروتينات في الـJacket الرئيسي أو المُركّبات
+
+557
+00:55:05,380 --> 00:55:11,310
+الموجودة فيها فالـIdea تبعت هذه الخليةالتشارك
+
+558
+00:55:11,310 --> 00:55:17,550
+الخلايا مع بعض بالتحكم ببعض والإشارة لبعض عن بعض
+
+559
+00:55:17,550 --> 00:55:22,130
+لعمل أشياء معينة تحرك الخلايا، انقسام الخلايا
+
+560
+00:55:22,130 --> 00:55:31,310
+انتصاق الخلايا ببعض حتى تكون عضو الإنفعال عند حدوث
+
+561
+00:55:31,310 --> 00:55:41,100
+مهيج خارجي وشيء خارجي كلها تعتمد علىيعني تفاعل
+
+562
+00:55:41,100 --> 00:55:49,240
+البروتينات مع بعض مع الواقع مع غيرها فالبروتينات
+
+563
+00:55:49,240 --> 00:55:52,360
+هذه اللي احنا بنشوفها ورسميها بهذا الشكل على هذا
+
+564
+00:55:52,360 --> 00:55:59,880
+المستوى تكون نتيجة إنه من الجينوم اللي هو مجمل
+
+565
+00:55:59,880 --> 00:56:07,160
+المادة الوراثية الـDNA كله يكون هناك قطع تسمى
+
+566
+00:56:07,160 --> 00:56:14,620
+جيناتماشي، كل جين بتتم عملية راح نحكي عملية الـ
+
+567
+00:56:14,620 --> 00:56:20,560
+Transcription ليعطينا الـ RNA اللي هو الـ
+
+568
+00:56:20,560 --> 00:56:25,900
+Messenger RNA طبعاً بالأول بيكون Primary RNA ممكن
+
+569
+00:56:25,900 --> 00:56:32,960
+مايكونش الـ Messenger أول ما يطلع وبتكون يعني RNA
+
+570
+00:56:32,960 --> 00:56:37,540
+يمكن هنا الـ Nascentأو Early أو الـPrimary RNA
+
+571
+00:56:37,540 --> 00:56:40,980
+بنسميه مثلا أحياناً فـHealth بيعطينا بعدين
+
+572
+00:56:40,980 --> 00:56:45,260
+بالـTranslation عملية إنه يعطينا البروتين البروتين
+
+573
+00:56:45,260 --> 00:56:50,600
+هذا هو اللي بيقدّي الوظيفة من خلال الـCell
+
+574
+00:56:50,600 --> 00:56:56,460
+Function اللي بيعطينا تكوين الـOrgans اللي بيعطينا
+
+575
+00:56:56,460 --> 00:57:02,320
+بعدين كل الـOrganism فيعني
+
+576
+00:57:02,320 --> 00:57:10,450
+الأخيركثير من الخواص والظواهر والـ «فاصيلة الدم»
+
+577
+00:57:10,450 --> 00:57:15,530
+ولون الشعر وقوة العضلات ووظيفة الإنسولين ووظيفة
+
+578
+00:57:15,530 --> 00:57:21,070
+المناعة ووظيفة كذا وذكاء هذا الإنسان وقدراته
+
+579
+00:57:21,070 --> 00:57:26,870
+العقلية وردود فعله كيف وكذا كلها بالأخير ترجع إلى
+
+580
+00:57:26,870 --> 00:57:33,330
+التفاعل الدرجة الأساسية للـGenomeمع ممكن الـ
+
+581
+00:57:33,330 --> 00:57:37,770
+Environment في جانب ثاني بحيث إنه بعطينا الـ Gene
+
+582
+00:57:37,770 --> 00:57:41,270
+Products اللي هم البروتينات اللي أنا بشوفها اللي
+
+583
+00:57:41,270 --> 00:57:45,470
+بالأخير بتعطيني خواص هذا الإنسان وميزته طبعا
+
+584
+00:57:45,470 --> 00:57:52,130
+الإنسان يعني إلا يكون البيئة إلها دور في قضية
+
+585
+00:57:52,130 --> 00:57:58,250
+مظهريته وقبراته السابقة وما اتعرض لهمن إشعاع
+
+586
+00:57:58,250 --> 00:58:04,570
+وكيمويات وغذاء واحتياجات وميكروبات وغيرها كلها
+
+587
+00:58:04,570 --> 00:58:12,510
+بتعطينا خاصية الواحد منها فهي أهمية فهم الجينوم
+
+588
+00:58:12,510 --> 00:58:24,050
+وفهم الجينات اللي فيه لما ندرس هذا الموضوع
+
+589
+00:58:25,370 --> 00:58:31,270
+فهنا مثلًا مثال، أنا كان صراحة عندي هيك بوستر كبير
+
+590
+00:58:31,270 --> 00:58:38,110
+حوالي يعني متر ونصف متر، يعني إشي كبير حاطين
+
+591
+00:58:38,110 --> 00:58:44,850
+الـ44، الـ46 كروموزوم أو الـ32، الـ23 كروموزوم على
+
+592
+00:58:44,850 --> 00:58:52,430
+أساس المعدل الـX والـY وحاطين كل واحد القطع تبعينه
+
+593
+00:58:53,340 --> 00:59:01,660
+الـ… الـ… الـChromosome لما نشوفه الـP القطعة
+
+594
+00:59:01,660 --> 00:59:07,680
+الصغيرة الـQ القطعة الطويلة هذه فبنسميها وبعدين
+
+595
+00:59:07,680 --> 00:59:13,820
+أنا ممكن أدرس يعني فيه من خلال تقنية الـPCR
+
+596
+00:59:13,820 --> 00:59:16,220
+Polymerase Chain Reaction اللي هي عملية
+
+597
+00:59:16,220 --> 00:59:21,570
+الـSequencing اللي هي أنه أنا أدرس الـ…الـ DNA
+
+598
+00:59:21,570 --> 00:59:26,250
+وأنا كنت ذكرت معلومة بالذات للـ DNA تبع البشر إنه
+
+599
+00:59:26,250 --> 00:59:32,610
+حوالي 95% منه لا قيمة له عبارة عن repeats وواضح
+
+600
+00:59:32,610 --> 00:59:37,050
+لما تيجي تقرأ كأنه يعني إذا اعتبرت أحرف
+
+601
+00:59:39,650 --> 00:59:45,370
+مثلًا، يعني نفترض إنه هذا الـGene هو قصيدة معينة
+
+602
+00:59:45,370 --> 00:59:53,870
+مثلًا، ولد ال .. يعني في مزح الرسول ﷺ أو طلع البدر
+
+603
+00:59:53,870 --> 00:59:59,010
+علينا، نفترض هيك، فبتلاقي قطعة كبيرة مثلًا، نفترض
+
+604
+00:59:59,010 --> 01:00:03,850
+بالأحرف مثلًا، ألف، ألف، ألف، ألف، ألف، ألف، ألف،
+
+605
+01:00:03,850 --> 01:00:07,010
+ألف، ألف، ألف، ألف، ألف، ألف، ألف، ألف، ألف، ألف،
+
+606
+01:00:07,010 --> 01:00:07,010
+ألف، ألف، ألف، ألف، ألف، ألف، ألف، ألف، ألف، ألف،
+
+607
+01:00:07,010 --> 01:00:07,010
+ألف، ألف، ألف، ألف، ألف، ألف، ألف، ألف، ألف، ألف،
+
+608
+01:00:07,010 --> 01:00:07,010
+ألف، ألف، ألف، ألف، ألف، ألف، ألف،
+
+609
+01:00:19,540 --> 01:00:20,940
+عالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعالبدعال
+
+610
+01:00:26,570 --> 01:00:31,170
+حكينا الـ Centromere اللي هو حكيناه هنا اللي
+
+611
+01:00:31,170 --> 01:00:38,010
+استفاد منه في عملية فصل الـ Myosis والـ Metaphase
+
+612
+01:00:38,010 --> 01:00:41,290
+وهذه
+
+613
+01:00:41,290 --> 01:00:45,130
+بتكون عملية الـ Bands لما أنا أجي أدرس الـ Band
+
+614
+01:00:45,130 --> 01:00:52,410
+هذه بلاقي إن أنا كل ما أدرس بشكل أدق بلاقي الجينات
+
+615
+01:00:52,410 --> 01:01:00,160
+موجودة بشكل مراتمناطق ما لهاش قيمة ومناطق غنية
+
+616
+01:01:00,160 --> 01:01:04,900
+بالجينات اللي هي بتأثر فمثلًا على الـ Chromosome
+
+617
+01:01:04,900 --> 01:01:15,340
+11 اللي هو 135 ميجا يعني اللي هو تقريبًا مليون
+
+618
+01:01:15,340 --> 01:01:21,520
+Base of DNA فلمّا
+
+619
+01:01:21,520 --> 01:01:27,990
+تيجي على الـ يعنيهذه القطع بعدين بيسموها في One
+
+620
+01:01:27,990 --> 01:01:35,190
+وTwo وThree وFour بيصير يسميهم ويعني هذه تعتبروها
+
+621
+01:01:35,190 --> 01:01:40,110
+زي إشارات على الطريق يعني أو تقسيمات أو شوارع أو
+
+622
+01:01:40,110 --> 01:01:47,150
+بلوكات أو يعني حتى يكون نوع من العنوان لإشي لما
+
+623
+01:01:47,150 --> 01:01:53,110
+نيجي ندرسه ففي الموقع الفلاني بنلاقي فيهاللي هو
+
+624
+01:01:53,110 --> 01:01:58,250
+مثلًا هنا Olfactory Receptor Gene يعني اللي هي
+
+625
+01:01:58,250 --> 01:02:06,290
+الجينات المسؤولة على مستقبلات حصة الشم فلما نيجي
+
+626
+01:02:06,290 --> 01:02:11,570
+نأخذها بشكل أدق بنلاقي مثلًا هنا Beta Chain، Delta
+
+627
+01:02:11,570 --> 01:02:18,570
+Chain، A, Gamma، G, Gamma، Epsilon، I، بتكون
+
+628
+01:02:18,570 --> 01:02:25,820
+موجودةودايمًا إحنا يعني كقاعدة لما نتكلم على
+
+629
+01:02:25,820 --> 01:02:31,040
+الـDNA إنه الـTranscription Direction اللي هو من
+
+630
+01:02:31,040 --> 01:02:36,100
+الخمس إلى الثلاث يعني هذه ترتيبها اللي تم عملية
+
+631
+01:02:36,100 --> 01:02:43,740
+الـTranscription تبعتها فهنا يعني نوع من التعقيد
+
+632
+01:02:43,740 --> 01:02:51,830
+بحيث إنه يعني شو أنا بحاجة إنهحتى أفهم من اللي هو
+
+633
+01:02:51,830 --> 01:02:56,050
+القطعة الكبيرة اللي فيها آلاف الكرموزومات آلاف
+
+634
+01:02:56,050 --> 01:03:06,330
+الجينات كواحد من الـ46 كرموزوم للجينوم بنزل الواحد
+
+635
+01:03:06,330 --> 01:03:18,980
+لمستوى إنه يشوف الجينات فيه واضح، فيها سلة،على هذا
+
+636
+01:03:18,980 --> 01:03:23,760
+الـ «سلايف»؟
+
+637
+01:03:23,760 --> 01:03:30,140
+طيب حكينا
+
+638
+01:03:30,140 --> 01:03:33,740
+نرجع
+
+639
+01:03:33,740 --> 01:03:45,160
+مرة ثانية الـ «DNA» في الـ «ريبوز» هذا للـ «RNA»
+
+640
+01:03:45,160 --> 01:03:53,720
+الـ «DNA» ديوكسي ريبوزفبكون في عندى Phosphate فالـ
+
+641
+01:03:53,720 --> 01:03:59,780
+الـ الـ الـ طرفي السلم اللولبي من الـ
+
+642
+01:03:59,780 --> 01:04:04,000
+Phosphatribose Phosphatribose Phosphatribose هدولة
+
+643
+01:04:04,000 --> 01:04:09,620
+الطرفين الدرج أو المصطبى اللي بتحط إجرك عليها في
+
+644
+01:04:09,620 --> 01:04:15,340
+السلم بتكون من Two Bases بكون شبكين الـ Base
+
+645
+01:04:15,340 --> 01:04:19,760
+Nitrogenous Base بتكون ماسكة بهذا الشكلفعندي
+
+646
+01:04:19,760 --> 01:04:26,540
+Purines وPrimidines وفي حالة الـ RNA فيه اختلافين
+
+647
+01:04:26,540 --> 01:04:33,880
+ثانيات الـ RNA فيه بدل الـ Deoxyribose فيه الـ
+
+648
+01:04:33,880 --> 01:04:45,340
+Ribose يعني بنقص منه ذرة Oxygen وبدل الـ T فيه U
+
+649
+01:04:45,340 --> 01:04:52,230
+الـ Uracineففيه اختلافين بالنسبة لشكل الـ… الـRNA
+
+650
+01:04:52,230 --> 01:04:57,710
+عن الـDNA هنا
+
+651
+01:04:57,710 --> 01:05:02,730
+يعني برضه تفصيل
+
+652
+01:05:02,730 --> 01:05:09,970
+لأنواع مختلفة من التركيب الـDNA على مستوى الـGene،
+
+653
+01:05:09,970 --> 01:05:18,310
+ماشي؟ الـGene هي قطع من الـDNA يتمعملية الـ
+
+654
+01:05:18,310 --> 01:05:24,250
+Transcription تبعتها إلى RNA وبالتالي بعد ذلك إلى
+
+655
+01:05:24,250 --> 01:05:32,850
+البروتين يعني هذه اللي بدنا نفهمها إحنا الآن نتكلم
+
+656
+01:05:32,850 --> 01:05:44,370
+على مستوى الـ DNA أي قطعة حتى يتم عملية نقلها،
+
+657
+01:05:44,370 --> 01:05:48,890
+اللي هي Transcriptionلأرى إنها حتى تتحول لـ
+
+658
+01:05:48,890 --> 01:05:56,790
+Protein بكون الـ الـ الـ الـ DNA تبعها في مكان
+
+659
+01:05:56,790 --> 01:06:05,710
+محدد بكون بشكل محدد وبكون يعني إله مجموعات من الـ
+
+660
+01:06:05,710 --> 01:06:10,850
+يعني من القطع حتى
+
+661
+01:06:10,850 --> 01:06:16,010
+يعني هنا بشكل افتراضيالـ Beta-Globulin تبع الـ
+
+662
+01:06:16,010 --> 01:06:22,330
+«هيموجلوبين» الـ «براكا» راح ناخد عنها وهي يعني
+
+663
+01:06:22,330 --> 01:06:25,410
+عبارة عن بروتين اللي له أهمية في انقسام القلايا
+
+664
+01:06:25,410 --> 01:06:30,350
+فهو مربوط وموجود في أنواع من السرطانات ولا
+
+665
+01:06:30,350 --> 01:06:34,410
+احتمالية يعني وجدوا وجود اختلالات في هذا الجين
+
+666
+01:06:34,410 --> 01:06:40,360
+بسبب أنه أنواع من السرطانات بتحدثوبروتين آخر أو
+
+667
+01:06:40,360 --> 01:06:46,580
+جين آخر مسؤول عن تكون العضلات في القلب فبيسوي
+
+668
+01:06:46,580 --> 01:06:50,160
+hypertrophic obstructive cardiomyopathy أو
+
+669
+01:06:50,160 --> 01:06:56,540
+كارديومايوباتي بيسوي ضعف عضلة القلب فالجينات هذه
+
+670
+01:06:56,540 --> 01:07:01,200
+على مستوى الـ DNA كل
+
+671
+01:07:01,200 --> 01:07:05,200
+واحد منهم هنا حاطين راح يصير بعدين إحنا شو ناخد
+
+672
+01:07:05,200 --> 01:07:14,220
+ككس؟عن مرض إله دخل بهذه الحالة فالـ الـ الـ الـ
+
+673
+01:07:14,220 --> 01:07:17,560
+لما ناخد إحنا الـ DNA راح نشوف الأشياء بهذه
+
+674
+01:07:17,560 --> 01:07:27,600
+الطريقة أي Gen يتم بعدين نسخه حتى يتم التعرف على
+
+675
+01:07:27,600 --> 01:07:31,780
+إن هذا هو الـ Gen وإنه احنا من هنا لازم نبدأ ننسخ
+
+676
+01:07:31,780 --> 01:07:38,580
+وبعدين كيف بدخل الأمور مع بعضباللاقي أنه يعني بعد
+
+677
+01:07:38,580 --> 01:07:45,040
+طبعاً أنا في الـ الـ الـ الـ strand أو في الجهة
+
+678
+01:07:45,040 --> 01:07:48,760
+اللي راح أنسخها من الـ five prime ل three prime
+
+679
+01:07:48,760 --> 01:07:53,480
+يعني هاي ده يعني قاعد نعتمد عليها و هيك بيعتبروها
+
+680
+01:07:53,480 --> 01:08:00,030
+أنه بالأول في promoted region يعنيفيه لازم يكون في
+
+681
+01:08:00,030 --> 01:08:05,850
+سلسلة الأحرف هذه فيه شيء معين أو قطعة معينة أو
+
+682
+01:08:05,850 --> 01:08:12,550
+ترتيب معين يكون يعني يساعدنا ويساعد عملية الـ
+
+683
+01:08:12,550 --> 01:08:17,150
+Transcription أنه تبدأ من هذا المكان حتى يطلع عندي
+
+684
+01:08:17,150 --> 01:08:21,170
+الـ Protein اللازم أو الـ RNA اللازم اللي بحتاجه
+
+685
+01:08:21,170 --> 01:08:28,230
+ففي عندي الـ Start of Transcription يعنيهنا في شيء
+
+686
+01:08:28,230 --> 01:08:33,390
+لما نبدأ عملية الـ Transcription بتروح، بتدور على
+
+687
+01:08:33,390 --> 01:08:40,870
+هذه قطعة حتى إنها تبدأ من هنا يعني إذا الواحد باخد
+
+688
+01:08:40,870 --> 01:08:44,090
+شوه عملية الـ Transcription، Translation يعني مشبه
+
+689
+01:08:44,090 --> 01:08:49,850
+الواحد بسحاب البنطلون أو سحاب الجاكيت أو الشيء
+
+690
+01:08:49,850 --> 01:08:54,950
+يعني فبدنا إشي بالأول انميز إنه أنا بدي أبدأ حتى
+
+691
+01:08:55,450 --> 01:08:58,970
+يغطبت هذا مع هذا بشكل جيد،
+إنه أنا بدي أبدأ من هذا
+
+692
+01:08:58,970 --> 01:09:04,350
+المكان بالنسبة للجينات ليس بالضرورة أن يكون الـ
+
+693
+01:09:04,350 --> 01:09:12,470
+Protein ناتج عن قطعة متصلة من الـ DNA أحيانًا أكثر
+
+694
+01:09:12,470 --> 01:09:19,150
+من قطعة بتتم استخدامها وبالتالي، لما نتكوّن على أي
+
+695
+01:09:19,150 --> 01:09:25,890
+بيتكلم على أي Protein هنا مثلًاهناك ما يسمى الـ
+
+696
+01:09:25,890 --> 01:09:31,050
+Exon والـ Intron الـ Intron هي القطع الـ
+
+697
+01:09:31,050 --> 01:09:34,430
+intervening sequences اللي لن يتم الاستفادة منها
+
+698
+01:09:34,430 --> 01:09:39,330
+وبالتالي يعني لما أنا بدي أكول البروتين الحقيقي
+
+699
+01:09:39,330 --> 01:09:44,190
+على مستوى الـ DNA بيكون بهذا الشكل فارط شويه زيادة
+
+700
+01:09:44,190 --> 01:09:51,790
+يعني متساق وهناك قطع من المنتصف لا يتم الاستفادة
+
+701
+01:09:51,790 --> 01:09:56,510
+منهاأحيانًا، يعني زي هذا البروتين الـIntrons
+
+702
+01:09:56,510 --> 01:10:00,890
+والـExons والـExons تبعينه تتساعر، يعني بهذا الشكل
+
+703
+01:10:00,890 --> 01:10:08,110
+ففي هذه المثال الـCodon،
+
+704
+01:10:08,110 --> 01:10:12,630
+الـInitiator الـCodon، راح نحكي عنه بعد شوية اللي
+
+705
+01:10:12,630 --> 01:10:16,950
+راح يبدأ العملية الـTranscription وراح يكون هذا
+
+706
+01:10:16,950 --> 01:10:21,450
+بدنا ناخده، هذا راح نقصه وما بدنا نشيهبناخد هذا
+
+707
+01:10:21,450 --> 01:10:24,290
+القطعة، وبعدين بنقص هذا الجزء وبعدين بناخد هذا
+
+708
+01:10:24,290 --> 01:10:28,050
+الجزء وبعدين بنقص هذا الجزء بهذه الطريقة لحد ما
+
+709
+01:10:28,050 --> 01:10:34,510
+أنهي المطلوب منه فهذه الظاهرة بتتم أنه على مستوى
+
+710
+01:10:34,510 --> 01:10:41,510
+الـDNA ما يتم يعني أحياناً بتكون هذه الظاهرة على
+
+711
+01:10:41,510 --> 01:10:47,400
+مثل مستوى الـRNA وبعدين اللي هي القص واللصب فيهابس
+
+712
+01:10:47,400 --> 01:10:54,160
+لازم يكون بالأول شيء يظهر للقالية عملية الـ
+
+713
+01:10:54,160 --> 01:10:58,500
+Transcription إنه ابدا من هذه النقطة Initiator
+
+714
+01:10:58,500 --> 01:11:03,680
+Codon و Termination Codon لوقف عملية نسخ تبع الـ
+
+715
+01:11:03,680 --> 01:11:11,220
+DNA لمسينجر RNA أو للـ RNA ولأنواع مختلفة بتلاقي
+
+716
+01:11:11,220 --> 01:11:16,810
+على كرموزومات مختلفة بتلاقي الجينات بهذا الشكلبكون
+
+717
+01:11:16,810 --> 01:11:21,410
+أنا بقرأ أشياء ما لهاش قيمة، ما لهاش معنى كتير،
+
+718
+01:11:21,410 --> 01:11:29,470
+وبعدين بدخل في مناطق بلاقي فيها مادة مفيدة لـ…
+
+719
+01:11:29,470 --> 01:11:34,670
+كجينها، فكان زمان يقدروا يمكن فيه خمسين لـ100 ألف
+
+720
+01:11:34,670 --> 01:11:38,990
+جين، بس لما عملوا الـHuman Genome وقروا
+
+721
+01:11:38,990 --> 01:11:42,390
+الـNucleotides واحد ورا الثاني، واحد ورا الثاني،
+
+722
+01:11:42,390 --> 01:11:45,860
+واحد ورا الثاني،لقينا، اللي هي الرقم اللي بيقدروا
+
+723
+01:11:45,860 --> 01:11:54,100
+الآن من 22 ألف لـ25 ألف Gen من خلال اللي هي إنه
+
+724
+01:11:54,100 --> 01:12:01,260
+واضح إنه هذه منطقة فيها شيء راح ينقره، أيوة، إيه
+
+725
+01:12:01,260 --> 01:12:05,900
+ناس؟ تفضلي، ليش
+
+726
+01:12:05,900 --> 01:12:06,520
+السؤال؟
+
+727
+01:12:12,050 --> 01:12:17,970
+دكتور أحمد، في سؤال إن شاء الله الأمور واضحة، أجل
+
+728
+01:12:17,970 --> 01:12:31,670
+فضلها دكتور أيناس، إذا عندك سؤال يبدو
+
+729
+01:12:31,670 --> 01:12:38,650
+أن هناك سؤال فإن شاء الله الأمور واضحة الآن، يعني
+
+730
+01:12:38,650 --> 01:12:42,810
+هذه نرجع مرة ثانيةلما واحد يتعامل مع الـ DNA
+
+731
+01:12:42,810 --> 01:12:47,550
+والوراثة بهذا الشكل مصطلح، Transcription،
+
+732
+01:12:47,550 --> 01:12:53,050
+Translation، Protein Assembly وصف الخطوات هذه، يجب
+
+733
+01:12:53,050 --> 01:13:00,290
+أن يكون الواحد فاهم حكينا
+
+734
+01:13:00,290 --> 01:13:05,230
+الـ DNA اللي هو الـ Double Helix اللي يتم قراءته
+
+735
+01:13:05,230 --> 01:13:14,800
+هو اللي من خمس لثلاثةماشي، فبتم
+
+736
+01:13:14,800 --> 01:13:20,500
+دايماً قراءة واحد من الـ Double Helix ما يتم قراءة
+
+737
+01:13:20,500 --> 01:13:27,240
+اتنين، بتكون من جهة واحدة، بكون من خمسة لثلاثة الـ
+
+738
+01:13:27,240 --> 01:13:35,740
+Transcription بنتج عنها اللي هو الـ يعني يسمونه
+
+739
+01:13:35,740 --> 01:13:43,400
+الـ nascent أو الـ الـ RNA الأوليماشي، وبكون عندي
+
+740
+01:13:43,400 --> 01:13:47,180
+فيه بالأول اللي هو «Start-up Codon» وفيه
+
+741
+01:13:47,180 --> 01:13:51,220
+«Termination Codon» حتى نعرف إنه أنا بحاجة إن أعمل
+
+742
+01:13:51,220 --> 01:13:55,660
+Transcription للقطعة هذه وأكملها، بيبدأ النظام زي
+
+743
+01:13:55,660 --> 01:14:00,360
+سحاب يمسك واحد واحد كل واحد من الـNucleotides
+
+744
+01:14:00,360 --> 01:14:05,000
+يقراها شو هي ويعطينا المكافئة تبعها حسب قليل
+
+745
+01:14:05,000 --> 01:14:10,020
+التصاق أو التكافؤبحيث إنه بنبدأ من هون وبتكون هي
+
+746
+01:14:10,020 --> 01:14:14,140
+ظاهرة لأنه أنا احتجت إني أنسخ هذا الـDNA في هذه
+
+747
+01:14:14,140 --> 01:14:18,760
+القطعة فتبدأ من هنا وبتظل أتكمل لحد ما تشوف أشي
+
+748
+01:14:18,760 --> 01:14:24,900
+كله وقف فلما انتصل هنا بوقف فهذا طلع إني اللي هو
+
+749
+01:14:24,900 --> 01:14:31,540
+الـPrimary RNA الـPrimary RNA في الـExons اللي هم
+
+750
+01:14:31,540 --> 01:14:35,380
+هذولة اللي تم الاستفادة منهم وفي إيش اسمه
+
+751
+01:14:35,380 --> 01:14:42,830
+الـIntron اللي بالنصرالـ Intron بتتم قصهم ولصق الـ
+
+752
+01:14:42,830 --> 01:14:51,630
+Messenger RNA بشكل متلاصق كامل بحيث أنه بنسميها
+
+753
+01:14:51,630 --> 01:14:56,230
+The Alternative أو RNA Processing أو Alternative
+
+754
+01:14:56,230 --> 01:15:00,950
+Splicing بتسموه مرات يعني قص و لصق على مستوى الـ
+
+755
+01:15:00,950 --> 01:15:08,920
+RNA بحيث أنه القطع المطلوبة تميعني لصقة بشكل
+
+756
+01:15:08,920 --> 01:15:15,660
+متلاصق بحيث يعطينا الـMessenger RNA المرحلة الأولى
+
+757
+01:15:15,660 --> 01:15:19,940
+بتكون في الـNucleus هنا المفروض يرسموننا
+
+758
+01:15:19,940 --> 01:15:25,500
+الـNuclear Membrane، P-Pores المسنجر RNA اللي هو
+
+759
+01:15:25,500 --> 01:15:32,580
+الكامل بتطلع لبرا فبروح جوا الـCytoplasm، بروح
+
+760
+01:15:32,580 --> 01:15:37,970
+بالذات على الـGolgi Apparatusبتم عملية بالذات الـ
+
+761
+01:15:37,970 --> 01:15:40,810
+Protein synthesis عند الـ Rough endoplasmic
+
+762
+01:15:40,810 --> 01:15:46,030
+reticulum اللي هي من تراكيب الخلية وفيها بتم عملية
+
+763
+01:15:46,030 --> 01:15:50,410
+بناء الـ Protein بناء الـ Protein إنه بيجي إشي
+
+764
+01:15:50,410 --> 01:15:58,970
+اسمه Ribosome زي الزبر تبع السحاب بيبدأ يشبك على
+
+765
+01:15:58,970 --> 01:16:04,050
+Messenger RNA ويكون هنا فيه، بيسموه Ribosome
+
+766
+01:16:04,050 --> 01:16:07,920
+الـRNAهذا الـ Messenger RNA وبعدين بيجي الـ
+
+767
+01:16:07,920 --> 01:16:13,840
+Ribosome الـ RNA الـ Ribosome الـ RNA بطريقة معينة
+
+768
+01:16:13,840 --> 01:16:20,340
+بيكون فيه الـ Transfer of RNA بشبك عليه الـ Amino
+
+769
+01:16:20,340 --> 01:16:30,340
+Acid فالـ… مع سير الـ Ribosome على الـ Messenger
+
+770
+01:16:30,340 --> 01:16:36,460
+RNA الـالـ Polypeptide Chain اللي هي الـ «أمانو
+
+771
+01:16:36,460 --> 01:16:41,080
+أسد» تتشبك وراء بعض، one after another بيصير تشبك
+
+772
+01:16:41,080 --> 01:16:44,600
+وراء بعض وبالتالي كل ما يقرأ أكتر بيعطينا حجم
+
+773
+01:16:44,600 --> 01:16:50,040
+البروتين أكبر بحيث إنه بالأخير بنتج عندي البروتين
+
+774
+01:16:50,040 --> 01:16:55,100
+وبعدين بسوي البروتين الـAssembly بهذا الشكل فهذه
+
+775
+01:16:55,100 --> 01:17:01,460
+الظواهر بتتم يعني إحنا هنا بنصف بالشكل أدق وتفصيلي
+
+776
+01:17:02,230 --> 01:17:09,490
+مجمل الظواهر في كيفية تحويل المعلومات والشفرة اللي
+
+777
+01:17:09,490 --> 01:17:13,470
+موجودة في الـ DNA بحيث إنه بالأخير تعطيني الـ
+
+778
+01:17:13,470 --> 01:17:18,230
+Protein أنا بحتاجه أو تحتاجه هذه الخلية بحيث إنه
+
+779
+01:17:18,230 --> 01:17:23,310
+راح يكون بالأول عملية unfolding of the DNA وبعدين
+
+780
+01:17:23,310 --> 01:17:27,810
+for the transcribed strand عملية الـ Transcription
+
+781
+01:17:28,640 --> 01:17:33,420
+وفيه اللي هي Starton وفيه End وفيه Poly-A-Addition
+
+782
+01:17:33,420 --> 01:17:38,500
+بالأخير حتى يكون نهاية وبعدين بيصير عملية تنظيف
+
+783
+01:17:38,500 --> 01:17:42,660
+للـRNA على مستوى الـRNA حيث إنه بيعطينا
+
+784
+01:17:42,660 --> 01:17:46,240
+الـMessenger RNA بيطلع في الـ… سواء Rough end
+
+785
+01:17:46,240 --> 01:17:49,640
+-plasmic reticulum نسميها Rough end-plasmic
+
+786
+01:17:49,640 --> 01:17:52,920
+reticulum لأنها بيكون فيها، لما واحد يشوف
+
+787
+01:17:52,920 --> 01:17:58,920
+الـRibosomes هذه بيشوفها، بيخلي المظهر مش Smoothمش
+
+788
+01:17:58,920 --> 01:18:07,840
+هيك يعني مجعلق يعني فبتصير عملية الـ Translation
+
+789
+01:18:07,840 --> 01:18:14,880
+اللي بتعطيني الـ Protein Assembly فهي الظواهر اللي
+
+790
+01:18:14,880 --> 01:18:18,260
+بتتم وهي كلها علوم يعني أنتوا أخدتوها الأصل
+
+791
+01:18:18,260 --> 01:18:23,160
+بالثانوية العامة أو بالمدارس وشغلات يعني مشهورة بس
+
+792
+01:18:23,160 --> 01:18:28,090
+الواحد يكون فاهم عنهادكتور، في سؤال من أحمد بخصوص
+
+793
+01:18:28,090 --> 01:18:32,530
+القضية اللي هو اتجاه عملية الـ Transcription تكون
+
+794
+01:18:32,530 --> 01:18:37,870
+من المبين في الصورة فعلاً من الـ3' إلى الـ5' هو
+
+795
+01:18:37,870 --> 01:18:41,310
+عملية اللي هو الـ Transcription على الـDNA لكن
+
+796
+01:18:41,310 --> 01:18:45,150
+عملية الـ Translation صارت من الـ5' إلى الـ3'
+
+797
+01:18:45,490 --> 01:18:51,390
+للـRNA، فهو بيسأل … بالله أنا اللي بقرا أنه الـ
+
+798
+01:18:51,390 --> 01:18:55,040
+Transcription Direction من 5 إلى 3بس انبهر في
+
+799
+01:18:55,040 --> 01:18:57,200
+الصورة أنه هو الـ «تجارب» – اللي بيكون غلط في
+
+800
+01:18:57,200 --> 01:19:02,740
+الرسم أحياناً ممكن تلاقي الرسمات غلط، فدايماً يعني
+
+801
+01:19:02,740 --> 01:19:05,460
+سواء في الـtranscription أو بتوقع حتى في
+
+802
+01:19:05,460 --> 01:19:11,000
+الـreplication الأليات إنك أنت بتبدأ من الـ يعني
+
+803
+01:19:11,000 --> 01:19:15,220
+الـ strand that is transcribed بيكون من الخمس
+
+804
+01:19:15,220 --> 01:19:22,860
+لثلاث، هيك بفهميعني هنا خمسة «برايم» لثلاثة
+
+805
+01:19:22,860 --> 01:19:27,800
+«برايم»، هيك بالفعل، ماشي فالـ «ستراند» الموجود
+
+806
+01:19:27,800 --> 01:19:32,200
+هنا اللي تم يعني النسخ منه من الـ الـ الـ اللي هو
+
+807
+01:19:32,200 --> 01:19:35,820
+الـ «DNA» كان الـ «ستراند» اتجاه النسخ عليه من
+
+808
+01:19:35,820 --> 01:19:40,440
+تلاتة «برايم» لخمسة «برايم» يعني هي شوية confusing
+
+809
+01:19:40,440 --> 01:19:47,680
+هناأنا يعني خلّيني يعني أقولك اللي كل ال .. أو
+
+810
+01:19:47,680 --> 01:19:51,640
+يعني كثير من المرة بيكتبوها يعني إنه في
+
+811
+01:19:51,640 --> 01:19:56,140
+الـReference Strand وفي الـكيف نتكلم مع الـStrand
+
+812
+01:19:56,140 --> 01:20:01,300
+وكيف بدنا نرتقل يعني لما شوفت الصورة اللي اختلفنا
+
+813
+01:20:01,300 --> 01:20:05,660
+عليها شوية في الخمس أشخاص اللي كنا عنها Reference
+
+814
+01:20:05,660 --> 01:20:11,060
+Strand وكدهإنه دايماً نمشي من الـ5' إلى الـ3'،
+
+815
+01:20:11,060 --> 01:20:14,160
+يعني هي كمية. هو المقصود، على حسب ما أذكر أنا
+
+816
+01:20:14,160 --> 01:20:19,260
+برضه، المقصود إنه إنشاء نسخة من الـDNA اللي هو
+
+817
+01:20:19,260 --> 01:20:23,960
+أساساً non-transcribed strand، يعني الهدف إنه أنا
+
+818
+01:20:23,960 --> 01:20:27,260
+أخد نسخة من الـnon-transcribed strand اللي هو من
+
+819
+01:20:27,260 --> 01:20:31,720
+5' إلى 3'. فأنا عشان هيك بنسخ من الـstrand
+
+820
+01:20:31,720 --> 01:20:37,580
+المقابل، اللي هو من 3' إلى 5'.شوف هاي معلومة دقيقة
+
+821
+01:20:37,580 --> 01:20:42,500
+كثير كثير كثير يمكن مالهاش فايد كثير، بس بشكل عام
+
+822
+01:20:42,500 --> 01:20:50,080
+لما نحكي عن ترتيب الـNucleotides ومواقعها، يعني
+
+823
+01:20:50,080 --> 01:20:56,900
+أنت أسا لما تأخذ بعدين، راح نتكلم على تسمي طفرة
+
+824
+01:20:56,900 --> 01:21:02,380
+معينة، فهيقولّك جي مثلا اللي هو يعني الـAmino Acid
+
+825
+01:21:02,380 --> 01:21:03,320
+الأولاني
+
+826
+01:21:05,620 --> 01:21:11,920
+بديل برقم 100 بعدين C مثلًا نفترض بهذا الشكل المية
+
+827
+01:21:11,920 --> 01:21:18,060
+هذه اللي بدك تأخذها إنه أنت بتقرأ القطعة من الـ
+
+828
+01:21:18,060 --> 01:21:22,280
+DNA و لا ال transcription و لا الـ كذا، راح تقراها
+
+829
+01:21:22,280 --> 01:21:26,340
+من الخمس إلى التلاتة، بدك تأخذها بهذا الشكل، فاهم
+
+830
+01:21:26,340 --> 01:21:31,650
+عليك كيف؟فهذه الصورة هي عملية النسخ، إنه أنا لما
+
+831
+01:21:31,650 --> 01:21:37,870
+أنسخ الـStrand اللي هو بيكون مقابل للـStrand
+
+832
+01:21:37,870 --> 01:21:41,190
+الأصلي أو خلّيني نسميه الـStrand اللي أنا بدي منه
+
+833
+01:21:41,190 --> 01:21:46,570
+نسخة هم اتنين، اسمعلي، اسمعلي، حسنا، انت لما يكون
+
+834
+01:21:46,570 --> 01:21:53,570
+عندك السلة من لولا بيه مع بعض، ماشي، تمام، تفصلوا،
+
+835
+01:21:53,570 --> 01:21:59,430
+صح؟إذا بدّي أعمل DNA replication، شو راح أسوي؟
+
+836
+01:21:59,430 --> 01:22:04,470
+الجهتين، كل واحد، راح أحط المقابل له «طبعًا»
+
+837
+01:22:04,470 --> 01:22:06,250
+«طبعًا» «طبعًا» «طبعًا» «طبعًا» «طبعًا» «طبعًا»
+
+838
+01:22:06,250 --> 01:22:06,710
+«طبعًا» «طبعًا» «طبعًا» «طبعًا» «طبعًا» «طبعًا»
+
+839
+01:22:06,710 --> 01:22:07,430
+«طبعًا» «طبعًا» «طبعًا» «طبعًا» «طبعًا» «طبعًا»
+
+840
+01:22:07,430 --> 01:22:12,550
+«طبعًا» «طبعًا» «طبعًا» «طبعًا» «طبعًا» «طبعًا»
+
+841
+01:22:12,550 --> 01:22:21,110
+«طبعًا» «طبع
+
+842
+01:22:22,650 --> 01:22:27,160
+واللي بيفرضوه لعملية الـ Transcriptionإن أنا باخد
+
+843
+01:22:27,160 --> 01:22:30,140
+من خمس إلى ثلاثة، هذا اللي بد يكون اللي بد أشتغل
+
+844
+01:22:30,140 --> 01:22:34,600
+عليه، أنا هيك بفهمه، بدي أتعامل …المقصد ده يا
+
+845
+01:22:34,600 --> 01:22:37,900
+دكتور يعني، والمقصد يعني، عشان يكون من خمس إلى
+
+846
+01:22:37,900 --> 01:22:43,340
+ثلاثة، فأنا مش حاجة أنسخ الـ DNA أو الـ strand
+
+847
+01:22:43,340 --> 01:22:48,000
+اللي هو من خمس إلى تلاتة، أنسخ العكس، من تلاتة إلى
+
+848
+01:22:48,000 --> 01:22:51,420
+خمس عشان أحصل على من خمس إلى تلاتة. أه، بس إحنا
+
+849
+01:22:51,420 --> 01:22:56,410
+يعني في الـ Standard، في تعاملنا،في عملية اللي إذا
+
+850
+01:22:56,410 --> 01:23:02,710
+بنعرف كهنا كانت Transcribed RNA أو Transcribed أو
+
+851
+01:23:02,710 --> 01:23:06,670
+في حالة اللي لما أنا أسوي report عن شو اللي اختلف
+
+852
+01:23:06,670 --> 01:23:12,750
+وكيف اختلف وكده بدي أقول إنه بتبدأ من خمسة بتروح
+
+853
+01:23:12,750 --> 01:23:17,270
+للثلاثة احفظوها بعد الشكل شايف علي؟ قلينا يعني
+
+854
+01:23:17,270 --> 01:23:23,210
+يمكن بدي الواحد يدخل تفاصيل أدقبس بعرفش إيه دا
+
+855
+01:23:23,210 --> 01:23:29,170
+يعني في كل الأوقات، في كل الظواهر بتتم بهذا الشكل،
+
+856
+01:23:29,170 --> 01:23:33,870
+ما بعرف، بس على قل هو المصطلح في التعامل مع هذا
+
+857
+01:23:33,870 --> 01:23:38,130
+الموضوع إنه أنا دايماً من خمس إلى ثلاث، إيه يخدها،
+
+858
+01:23:38,130 --> 01:23:42,550
+باتجاه اللي لما أقرأ الأشياء، بس واضح لما نسور DNA
+
+859
+01:23:42,550 --> 01:23:47,230
+replication إنه الجهتين بيشتغلوايعني لازم من خمس
+
+860
+01:23:47,230 --> 01:23:50,810
+لثلاث لثلاث خمس لما أنا بقصلهم بدي أبني هذا و أبني
+
+861
+01:23:50,810 --> 01:23:56,170
+هذا بدك تكون قادر على إنك تعمل شغلتين مع بعض فاهم
+
+862
+01:23:56,170 --> 01:24:01,510
+عليك كده على كل هذا أنا مش متأكد مية بالمية منه
+
+863
+01:24:01,510 --> 01:24:06,650
+خلينا شوية، ماشي؟ ما شاء الله في أسئلة ثانية؟
+
+864
+01:24:07,510 --> 01:24:11,270
+وغالبا يعني الطلاب بيتناقشوا على قضية اللي هو يعني
+
+865
+01:24:11,270 --> 01:24:13,910
+هذا المعلومات معظمها يعني مرت عليهم قبل هيك في ال
+
+866
+01:24:13,910 --> 01:24:18,730
+molecular وهم يعني يعني اللي اختلف عليهم قضية اللي
+
+867
+01:24:18,730 --> 01:24:22,830
+هو بالأرقام فهم بيسألوا على هذه النقطة لكن غالبا
+
+868
+01:24:22,830 --> 01:24:27,150
+يا دكاتر يعني نفس المعلومات اللي أخدتها بال
+
+869
+01:24:27,150 --> 01:24:31,870
+molecular هي يعني تنطبق هنا يعني هي تكملة لما سبق
+
+870
+01:24:31,870 --> 01:24:32,210
+يعني
+
+871
+01:24:35,540 --> 01:24:41,580
+في سؤال من دكتورة ويجدان في نقطة الـPolar Body
+
+872
+01:24:41,580 --> 01:24:46,660
+يعني هل الـPolar Body هو نفس الكوربس الوتيام؟ لا
+
+873
+01:24:46,660 --> 01:24:52,720
+طبعا، يعني هذه واحدة على مستوى النواء وواحدة على
+
+874
+01:24:52,720 --> 01:24:59,200
+مستوى الخلايا بشكل عاملأ، بالنسبة لهذا الموضوع
+
+875
+01:24:59,200 --> 01:25:05,880
+كوربوس الـ UTM هذا بعد الإخصاب وبعدين إشي مختلف
+
+876
+01:25:05,880 --> 01:25:11,880
+بولر بيدي في البويضة اللي لسه بدها تنتج قبل ما
+
+877
+01:25:11,880 --> 01:25:17,420
+تتلقى، بيكون معاها البويضة بيكون فيه two polar
+
+878
+01:25:17,420 --> 01:25:25,430
+bodies وهم يمثلوا إذا أخدنا الـ DNA 3Mكانت اللي ما
+
+879
+01:25:25,430 --> 01:25:31,890
+استفدناش منهم، فاهمة عليه؟ لأن أول كانت تكونت 4M،
+
+880
+01:25:31,890 --> 01:25:36,490
+وانقسمت لـ2 2M، لثنتين، كل واحدة فيها 2M، واحدة
+
+881
+01:25:36,490 --> 01:25:42,250
+منهم راح تجمد، وراح تضمر، وكذا، فبتظل واحدة فيها
+
+882
+01:25:42,250 --> 01:25:47,190
+2M، وبعدين لما تنقسم مرة ثانية وتصير 1N، اللي هي
+
+883
+01:25:47,190 --> 01:25:50,990
+الـEgg، برضه الواحدة الثانية اللي فيها 1N، راح
+
+884
+01:25:50,990 --> 01:25:56,780
+تضمر، فهي برضه راح تصير.ماشي؟ فيه برضه يعني شاف
+
+885
+01:25:56,780 --> 01:26:01,660
+الدكاترة بيرجع يسأله قبل فيه برضه سؤال بتقول
+
+886
+01:26:01,660 --> 01:26:05,880
+دكتورة أسماء فيه إمكانية إنه بس تعيد شرح نقطة
+
+887
+01:26:05,880 --> 01:26:12,160
+الـTelomere؟ الـTelomere هي قطعة في طرف
+
+888
+01:26:12,160 --> 01:26:20,840
+الـChromosome من فوق أو من تحت هي أنا تخيلي إنها
+
+889
+01:26:20,840 --> 01:26:28,710
+عبارة عن آليةلمعرفة عمر الخلية من ناحية قدرتها على
+
+890
+01:26:28,710 --> 01:26:37,070
+انقسام فزي مسبحة حكينا بيقدروا العلماء إنه الخلية
+
+891
+01:26:37,070 --> 01:26:41,790
+الـFertilized egg الجديدة الإنسان أول ما يولد، ليش
+
+892
+01:26:41,790 --> 01:26:47,150
+الإنسان مايظلوش مخلط؟ خلايا بيظلها إنه إلها قدرة
+
+893
+01:26:47,150 --> 01:26:52,870
+معينة على انقسام، بعدين بتتطل، تنقسمفهذه قلية ليش
+
+894
+01:26:52,870 --> 01:26:56,550
+العجوز أو الإنسان الكبير بالعمر وقلايا ما بتنقسم
+
+895
+01:26:56,550 --> 01:27:01,370
+جزء منه إنه الـ Telomere اللي هو الـ «تلي» يعني
+
+896
+01:27:01,370 --> 01:27:07,890
+بعيد أو مطرف فالـ Telomere فيه عبارة عن زي مسبحة
+
+897
+01:27:07,890 --> 01:27:12,990
+أو حبات مسبحة، كيف خير، في طرف الـChromosome بحيث
+
+898
+01:27:12,990 --> 01:27:18,560
+إنه مع كل انقسام حب بتطير، حب بتطير، حب بتطيرفلما
+
+899
+01:27:18,560 --> 01:27:23,540
+أنا بفترض تقديراً يعني بتوقع يمكن ما بعرفش رقم 100
+
+900
+01:27:23,540 --> 01:27:28,420
+% حوالي 60 حب لأنه يقال إن الخلايا تنقسم 60 مرة
+
+901
+01:27:28,420 --> 01:27:33,040
+ولمّا تنقسم 60 مرة هذا بتعطينا كمية مهولة جداً من
+
+902
+01:27:33,040 --> 01:27:40,560
+الخلايا يعني إشي كبير جداً فالـTelomere لما يعني
+
+903
+01:27:40,560 --> 01:27:45,780
+تسمع في الكتب أو في الدراسات يقولّك والله النعجة
+
+904
+01:27:45,780 --> 01:27:53,840
+دوليصحيح ولدت من خلية أمها اللي هي يعني ولدت اليوم
+
+905
+01:27:53,840 --> 01:28:00,680
+بس حقيقة يعني الأم كانت مثلا نفترض زي مثلا نفترض
+
+906
+01:28:00,680 --> 01:28:06,900
+بشر إنسان عمره ثلاثين سنة واخدت منه خلية نقلتها في
+
+907
+01:28:06,900 --> 01:28:11,820
+استنساخ عملت خلية ثانية وكائن بشري تاني الطفل أو
+
+908
+01:28:11,820 --> 01:28:16,130
+الإنسان هذا لما يولد عمره ثلاثين مش عمره يوميعني
+
+909
+01:28:16,130 --> 01:28:21,590
+ما يعني إذا الإنسان بعيش سبعين سنة الإنقسامات
+
+910
+01:28:21,590 --> 01:28:25,710
+الباقية له اللي هي أربعين سنة عشان هيك المعجد دول
+
+911
+01:28:25,710 --> 01:28:31,450
+ماتت مبكراً، شايخوها مبكراً لأنه قليتها عمرها كبير
+
+912
+01:28:31,450 --> 01:28:37,570
+بسبب إنه الـ… شو اسمه؟ قليتها عمرها كبير بسبب إنه
+
+913
+01:28:37,570 --> 01:28:44,350
+الـ… الـ… شو اسمه؟ الـTelomeres دولة أقللأن
+
+914
+01:28:44,350 --> 01:28:48,570
+المسبحة انقسم منها كثير بالانقسامات القديمة يعني
+
+915
+01:28:48,570 --> 01:28:54,750
+بهذا الشكل بدنا نفهمه، واضح؟ إن شاء الله يكون
+
+916
+01:28:54,750 --> 01:28:59,930
+الجواب يعني وصل إلى الدكتورة أسماء الدكتورة هذه
+
+917
+01:28:59,930 --> 01:29:03,410
+اللي بتقول يعني الـPolar Body خلية فيها Cytoplasm
+
+918
+01:29:03,410 --> 01:29:08,230
+قليل يعني نعم، صحيح، وجاي على الطرف، يعني الجسم
+
+919
+01:29:08,230 --> 01:29:15,260
+القطبي الـPolar يعني قطبي، صحيح؟ أهطبعًا، لحد الآن
+
+920
+01:29:15,260 --> 01:29:19,500
+الأسئلة هي كذلك، تم الإجابة عليها تقريبًا ومعظمها
+
+921
+01:29:19,500 --> 01:29:24,880
+نقطة الأخيرة، واللي خلّينا على الموضوع هذا طويل،
+
+922
+01:29:24,880 --> 01:29:29,080
+صارت الساعة عشرة فموعدنا غدا إن شاء الله ساعة
+
+923
+01:29:29,080 --> 01:29:33,420
+تمانية ونص، ونبدأ من هذه النقطة إذن الله تعالى، بس
+
+924
+01:29:33,420 --> 01:29:38,260
+بعد إذنك يا دكتور إذا الـ PowerPoint بالظبط ببعتلك
+
+925
+01:29:38,260 --> 01:29:44,060
+الآن محاضرتين، اليوم وبكرة إن شاء الله رب العالمبس
+
+926
+01:29:44,060 --> 01:29:48,320
+يبقى نفسي اللي في الكتابفي الغالب ما جبتش إشي
+
+927
+01:29:48,320 --> 01:29:52,580
+خارجي، ماشي، ماشي فيه بس بعد إذنك يا دكتور قبل ما
+
+928
+01:29:52,580 --> 01:29:57,300
+ننهي فيه يعني كان اقتراح من بعض الطلاب بخصوص ال
+
+929
+01:29:57,300 --> 01:30:04,400
+slides لو يتم بس يعني كتابة بعض النقاط يعني بعد
+
+930
+01:30:04,400 --> 01:30:09,480
+الصور أو كذا عشان تكون معينة يعني على الخلال عملية
+
+931
+01:30:09,480 --> 01:30:13,500
+التدوين في الشرح المتابع للشرح يعني بعض النقاط
+
+932
+01:30:13,500 --> 01:30:18,950
+الرئيسية اللي بتكلم عن كل صورةاسمع علي، المرجع
+
+933
+01:30:18,950 --> 01:30:25,730
+بصراحة ثري جدا وعميق الأصل
+
+934
+01:30:25,730 --> 01:30:29,590
+يعني إذا الواحد ماعندهوش قدرة أو يمكن تفاصيل
+
+935
+01:30:29,590 --> 01:30:35,470
+المعلومات هي جيدة تكون مرجع لوحد مثلا بدهو يعطي
+
+936
+01:30:35,470 --> 01:30:40,870
+المحاضرة أو بده يفهم نقطة محددة بشكل دقيق يعني زي
+
+937
+01:30:40,870 --> 01:30:44,490
+اللي أختك بتفهم عن Polar Body بشكل أدق ولا كده
+
+938
+01:30:44,990 --> 01:30:50,290
+فبتلاقي يمكن فقرة جوا موجودة أنا بعتبر إنه مدان ما
+
+939
+01:30:50,290 --> 01:30:56,210
+ركزتش عليها يعني إنها مش كتير مهمة لكم يعني فالآن
+
+940
+01:30:56,210 --> 01:31:03,410
+اللي أنا بفضل إنه يعني كل محاضرة عبارة عن فصل من
+
+941
+01:31:03,410 --> 01:31:09,890
+الكتاب الفصل هتلاقي فيه مقدمة، فيه جداول، في
+
+942
+01:31:09,890 --> 01:31:16,640
+الرسمات هي بنعرضهابالأخير فيه يعني ملخص فأنا اللي
+
+943
+01:31:16,640 --> 01:31:21,840
+باقترحه إنه كمان الواحد يرجع للنقاط الرئيسية في
+
+944
+01:31:21,840 --> 01:31:30,020
+الكتاب اللي هي العناوين الجداول الصور إذا إشي حاطب
+
+945
+01:31:30,020 --> 01:31:33,520
+بنت عليه عريض هذه اللي الواحد الأشياء اللي يركز
+
+946
+01:31:33,520 --> 01:31:39,900
+عليها فإنتوا كمان يعنيالتفاريغ دايماً بقول كانت
+
+947
+01:31:39,900 --> 01:31:44,080
+مفيدة إليه لما أنا أكون اللي كتبتها، أن أنا بتذكر،
+
+948
+01:31:44,080 --> 01:31:47,940
+فاسمعوا كلامي وشوفوا الكتاب، ارجعوا هيك إليه
+
+949
+01:31:47,940 --> 01:31:52,180
+بسرعة، لا تضيعوا وقتك كثير في تفاصيل المعلومات
+
+950
+01:31:52,180 --> 01:31:58,120
+الخط الصغير، المعلومات الكثيرة، يعني هي بتعينك على
+
+951
+01:31:58,120 --> 01:32:02,180
+الفهم بشكل اللي يعني من خلال زي ما أنا بقول هيك،
+
+952
+01:32:02,180 --> 01:32:07,870
+بشرح كيف تظهر هذا بالتم أو كيفكذا، أما التفاصيلة
+
+953
+01:32:07,870 --> 01:32:13,190
+مش راح تكون يعني إذا الفاحد فهم المبدأ و القاعدة
+
+954
+01:32:13,190 --> 01:32:17,830
+زي ما بيقوله بيقدر يتكر الأشياء بإذن الله تعالى،
+
+955
+01:32:17,830 --> 01:32:20,490
+ان شاء الله رب العالمين، يعطيك العفو يا دكتور الله
+
+956
+01:32:20,490 --> 01:32:23,530
+يرضي عليكم، نراح نقتل إن شاء الله، إن شاء الله رب
+
+957
+01:32:23,530 --> 01:32:27,470
+العالمين، نكمل من هنا، السلام عليكم، السلام عليكم،
+
+958
+01:32:27,470 --> 01:32:28,010
+في رعاية الله
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/SNmO_a0evPg.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/SNmO_a0evPg.srt
new file mode 100644
index 0000000000000000000000000000000000000000..9e3e2f05e5d79439d19ddebd946a5f79f2b83b1d
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/SNmO_a0evPg.srt
@@ -0,0 +1,3179 @@
+1
+00:00:00,000 --> 00:00:05,440
+الـ slide بالضبط هو اللي قصده، بدي يعني أتكلم عنه
+
+2
+00:00:05,440 --> 00:00:14,660
+الفكرة أنه هناك درجة عالية من الاختلافات بين الـ
+
+3
+00:00:14,660 --> 00:00:22,460
+DNA للبشر، بحيث أنه بأي أسلوب أو بأي يعني عدسة
+
+4
+00:00:22,460 --> 00:00:27,980
+مكبرة مستخدمة، ممكن نلاقي درجات من الاختلافات في
+
+5
+00:00:27,980 --> 00:00:33,870
+الـ SNPs، اللي هي Single Nucleotide Polymorphisms، فهي
+
+6
+00:00:33,870 --> 00:00:40,610
+بتكون على مستوى حرف واحد، يعني على مستوى إذا
+
+7
+00:00:40,610 --> 00:00:50,090
+بتخيلنا الـ… الـGenome، كل الـ… كل القصائد باللغة
+
+8
+00:00:50,090 --> 00:00:56,450
+العربية مثلاً، الـ… البروتين هو قصيدة محددة، البروتين
+
+9
+00:00:56,450 --> 00:01:01,750
+يتكون من أحرف، ماشي؟ لأن القصيدة تتكون من أبيات
+
+10
+00:01:01,750 --> 00:01:09,050
+والأبيات تتكون من أحرف، فالـ… الـ SNP هو اختلاف
+
+11
+00:01:09,050 --> 00:01:14,910
+في حرف واحد، واتفقنا على أنه تقريباً نتكلم على أنه
+
+12
+00:01:14,910 --> 00:01:19,570
+في حوالي من خمسة إلى عشرة ملايين SNPs عادةً في أي
+
+13
+00:01:19,570 --> 00:01:22,330
+جينوم بشري، يعني
+
+14
+00:01:25,820 --> 00:01:34,280
+هي على مستوى الحرف الدقيق اللي هو المحدد، يعني أما
+
+15
+00:01:34,280 --> 00:01:41,980
+لما نيجي نتكلم عن، بالنسبة لـ… نيجي نتكلم على
+
+16
+00:01:41,980 --> 00:01:49,360
+مستويات أوسع من الـ… من الـVariations أو الاختلافات
+
+17
+00:01:49,360 --> 00:01:55,370
+ونشوف على مستوى أكبر، أنا بأعتبر هذا الـ "سلايد" من
+
+18
+00:01:55,370 --> 00:02:01,550
+أهم الـ "سلايدات"، إذا بدي أحد يقول فاهم شيء، يكون
+
+19
+00:02:01,550 --> 00:02:08,910
+منتبه له، لما نيجي ندرس على مستوى الـ "كروموزوم"
+
+20
+00:02:08,910 --> 00:02:15,210
+كله، والـDNA كله، والجينوم كله، هيك بشكل عام، يعني
+
+21
+00:02:15,210 --> 00:02:21,650
+نعتبره بشكل مش دقيق كثير، مش على مستوى الأحرف
+
+22
+00:02:22,150 --> 00:02:25,590
+بسميهم الـ Standard Karyotyping، وحكيت لكم كيف
+
+23
+00:02:25,590 --> 00:02:29,750
+بيكون، وبيكون على مستوى عشرة أو تسعة الـ
+
+24
+00:02:29,750 --> 00:02:33,890
+Nucleotide Base Pairs كلهم، يعني المليارات، مرة
+
+25
+00:02:33,890 --> 00:02:39,710
+واحدة، هذا الـ Karyotyping، إذا بتطلع على الـ Bands
+
+26
+00:02:39,710 --> 00:02:44,250
+اللي بشوفه باستخدام صبغات، يا أما Routine Binding
+
+27
+00:02:44,250 --> 00:02:48,530
+أو High Resolution Binding، يعني بشوف الفرقيات
+
+28
+00:02:48,530 --> 00:02:53,330
+الموجودة على الكروموزومات، وبحاول أدرسها في مستوى
+
+29
+00:02:53,330 --> 00:02:57,770
+أدق شوية، بعدين في عندي techniques هنا، مجموعة
+
+30
+00:02:57,770 --> 00:03:05,530
+من أصعب الأشياء، ويمكن لكل تشخيص فيه ألية
+
+31
+00:03:05,530 --> 00:03:10,130
+معينة نستخدمها، اللي هي الـFISH
+
+32
+00:03:10,130 --> 00:03:15,000
+والـMicroarray، والـMicrochromosome، يعني هنا كأنه أنا
+
+33
+00:03:15,000 --> 00:03:22,440
+بصير أبحث في القصائد، بشكل، نسميهم أبيات شعر معينة
+
+34
+00:03:22,440 --> 00:03:27,820
+مثلاً، يمكن أصير أدور فيهم نفس البيت أو شيء زي هيك
+
+35
+00:03:27,820 --> 00:03:32,220
+يعني، مجموعة أكبر شوية من هنا، نبحث عن لحظة محددة
+
+36
+00:03:32,670 --> 00:03:36,310
+وفي لما أنا قاعد أفحص على مستوى الـ…
+
+37
+00:03:36,310 --> 00:03:40,990
+الـ Nucleotide والـ Base Pair كل واحد لوحده، بسوي
+
+38
+00:03:40,990 --> 00:03:44,790
+Whole Genome Sequencing، هذه بيكون الـResolution
+
+39
+00:03:44,790 --> 00:03:50,550
+لحد واحد الـ Nucleotide، تصير دقة عالية جداً، فهذه
+
+40
+00:03:50,550 --> 00:03:56,910
+يعني كل واحدة منهم مفيدة في حالة معينة، في تشخيص
+
+41
+00:03:56,910 --> 00:04:03,130
+معين، في مرض معين، لما يكون عندي مشاكل على شكل
+
+42
+00:04:03,130 --> 00:04:08,110
+مثلاً زي Down Syndrome، لا، المشكلة عادةً إنه
+
+43
+00:04:08,110 --> 00:04:14,750
+كروموزوم كامل فيه زيادة، Trisomy 21 مثلاً، بينما
+
+44
+00:04:14,750 --> 00:04:19,530
+مثلاً إذا بدور على مرض آخر، يمكن أعمل Whole Genome
+
+45
+00:04:19,530 --> 00:04:25,490
+Sequencing، فهذه بأعتبرها من أهم الـSlides اللي لازم
+
+46
+00:04:25,490 --> 00:04:30,810
+واحد يتخيله ويعرفه، ويعرف أمثلة عليه، وشو وليه
+
+47
+00:04:30,810 --> 00:04:37,150
+بنحتاج في هذه الطريقة، فالآن، هاي اللي سموها الـ
+
+48
+00:04:37,150 --> 00:04:44,270
+Ideogram، الـ G-banding، النطاقات اللي هي الموجودة
+
+49
+00:04:44,270 --> 00:04:51,850
+على الـ كروموزومات، لما نكون في مرحلة الـ Metaphase
+
+50
+00:04:51,850 --> 00:04:58,490
+من الـ… من الـ Cell Division، وبيكون الـ DNA على شكل
+
+51
+00:04:58,490 --> 00:05:07,850
+DNA compressed، يعني مضغوط، وبيكون على شكل أصغر شيء
+
+52
+00:05:07,850 --> 00:05:16,430
+حتى نقدر نقسم الـ… الـ… الـ two sets of chromosomes
+
+53
+00:05:16,430 --> 00:05:25,360
+to each cell، فهذه بتكون كيف بتكون؟ هنا رؤية أدق
+
+54
+00:05:25,360 --> 00:05:30,860
+ومقربة أكثر للـ Chromosome والـ Bands اللي موجودة
+
+55
+00:05:30,860 --> 00:05:36,020
+عليها وتقسيماتها، وفي High Resolution Banding، يعني
+
+56
+00:05:36,020 --> 00:05:42,520
+حتى بيعطينا عدد أكبر من الدقة، نشوفه هون، احنا
+
+57
+00:05:42,520 --> 00:05:48,020
+بنستخدم تقنية الـ FISH، الـ Fluorescence اللي هي إنه
+
+58
+00:05:48,020 --> 00:05:54,880
+فيه صبغة بتشع عليها ضوء معين، بتعطيني ضوء ثاني، فعادةً
+
+59
+00:05:54,880 --> 00:06:00,000
+نختار أنواع الصبغات اللي بتعطينا فيها الـ Same
+
+60
+00:06:00,000 --> 00:06:04,240
+Excitation Wavelength للـ Laser أو للـ Light
+
+61
+00:06:04,240 --> 00:06:08,420
+وبتعطينا Different Emission Wavelength، حتى أقدر
+
+62
+00:06:08,420 --> 00:06:16,500
+أميز إيش اللي بشوفه، الـ Dye هنا أنا حاططها على
+
+63
+00:06:16,500 --> 00:06:24,410
+Probe بتروح، بتدور على certain DNA sequence أنا مهتم
+
+64
+00:06:24,410 --> 00:06:32,510
+فيه، فهنا يعني أنا بدور الـ "كلمة" نرجعها لبيت
+
+65
+00:06:32,510 --> 00:06:40,370
+شعر معين في القصائد، فبربط عليه مادة ملونة، وبحطها
+
+66
+00:06:40,370 --> 00:06:44,550
+على الخلايا
+
+67
+00:06:44,550 --> 00:06:49,120
+اللي هي في حالة الـ Metaphase، ويكون عندك كروموزومات
+
+68
+00:06:49,120 --> 00:06:55,200
+وبحاول أشوف وين في اتّصال لهذه الـ Probe بالإيش
+
+69
+00:06:55,200 --> 00:06:59,640
+المُركّب لها، يعني ألاقي البيت اللي أنا دورّت عليه
+
+70
+00:06:59,640 --> 00:07:04,860
+من القصيدة، عشان تلزق عليه، كمجموعة طويلة شوية مش
+
+71
+00:07:04,860 --> 00:07:11,000
+Single Nucleotide، وهنا مرة بنعتبرها إيجابية
+
+72
+00:07:11,000 --> 00:07:16,530
+ومرة بنعتبرها سلبية، هنا مثلاً الـ Binding تبع الـ
+
+73
+00:07:16,530 --> 00:07:23,810
+X-Chromosome، ماشي؟ وهكذا يكون شكله، ويكون فيه حالات
+
+74
+00:07:23,810 --> 00:07:29,270
+مختلفة، وأشياء مختلفة، الـ Microarray برضه يعني
+
+75
+00:07:29,270 --> 00:07:34,410
+فكرتها، أهم شيء الواحد ياخذها، أنه هنا أنا بدور على
+
+76
+00:07:34,410 --> 00:07:44,030
+بشكل عام، على قطع DNA، يعني Sequence معينة، بيمكن
+
+77
+00:07:44,030 --> 00:07:51,410
+مثلاً خمسين، مئة Base محددة، بترتيب معين، يعني أحرف
+
+78
+00:07:51,410 --> 00:07:58,490
+معينة بتكون بشكل معين، فهذه بدنا يعني يستطيع الواحد
+
+79
+00:07:58,490 --> 00:08:05,090
+يستخدمها، ويدرس الموضوع، وهي مفيدة إنه يتخيلها
+
+80
+00:08:05,090 --> 00:08:09,960
+الواحد في تشخيص حالة محددة، راح نحكي عن استخداماتها
+
+81
+00:08:09,960 --> 00:08:17,000
+وكيف تكون، في سؤال من الدكتورة هديل، بتتكلم، بتسأل
+
+82
+00:08:17,000 --> 00:08:20,620
+يعني هل نعتبر الـ SNPs من ضمن الـ Polymorphisms
+
+83
+00:08:20,620 --> 00:08:24,540
+والـ Substitutions ضمن الـ Mutations، علماً أن الاثنين
+
+84
+00:08:24,540 --> 00:08:29,260
+بيصير فيهم Single Base، يعني؟ لا، لا، اسمعي، كلمة
+
+85
+00:08:29,260 --> 00:08:38,990
+Polymorphism، تعدد الصور، ماشي؟ هي الحالة عندما يكون
+
+86
+00:08:38,990 --> 00:08:47,790
+نسبة حدوث هذه الطفرة أكثر من 1% من الـ Human
+
+87
+00:08:47,790 --> 00:08:54,510
+population، يعني كلمة الـ Mutation، okay، يعني اللي هي
+
+88
+00:08:54,510 --> 00:08:59,890
+قضية كلمة إنه يقول طفرة، الطفرة بدل واحد، يعني يكون
+
+89
+00:08:59,890 --> 00:09:06,860
+متأكد أول شيء أنه هو تغير عن الطبيعي، فممكن أنا إذا
+
+90
+00:09:06,860 --> 00:09:11,260
+ما عندي دراسة كاملة لكل البشر، بحيث أنا أعرف شو هو
+
+91
+00:09:11,260 --> 00:09:18,400
+طبيعي، حتى أقرر شو هو مش طبيعي، هنا بتصير الأمور يعني
+
+92
+00:09:18,400 --> 00:09:27,420
+صعبة شوية لتقييمها، بينما عندما نتكلم عن كلمة كانت
+
+93
+00:09:27,420 --> 00:09:33,800
+ضمن تعريف الـ Polymorphism، أن نسبة حدوث هذه الظاهرة
+
+94
+00:09:34,510 --> 00:09:42,850
+بتكون بنسبة أكثر من 1% من الـ Population، لما نتكلم
+
+95
+00:09:42,850 --> 00:09:50,430
+عن SNP، بالذات على مكان محدد، في محل محدد، في
+
+96
+00:09:50,430 --> 00:09:56,150
+دراسة معينة، ماشي؟ عند مشاهدتها، بدنا نسميها SNP
+
+97
+00:09:56,150 --> 00:10:02,090
+هي كلها أنواع تفرعات الاختلاف
+
+98
+00:10:02,090 --> 00:10:08,390
+أنه حكينا الأنواع الثانية من الـ Mutations اللي هي
+
+99
+00:10:08,390 --> 00:10:15,730
+إنها قطعة كبيرة تتكرر، قطعة كبيرة تنقلب، تسمى inversion، قطعة كبيرة تنحذف، هاي في الغالب يعني
+
+100
+00:10:15,730 --> 00:10:22,950
+تأثيرها شديد على وظيفة الـ Protein والجين المعني
+
+101
+00:10:22,950 --> 00:10:27,890
+في هذه الظاهرة أو في هذه القطعة، بينما لما نتكلم على
+
+102
+00:10:27,890 --> 00:10:35,680
+الـ SNP بالذات، لدى الواحد يتذكر أنهم أنواع
+
+103
+00:10:35,680 --> 00:10:41,940
+التفرات أو أنواع الـ Mutations اللي بتحدث
+
+104
+00:10:41,940 --> 00:10:46,600
+ولكن قد يكون في أحيان كثيرة مالهاش قيمة يعني
+
+105
+00:10:46,600 --> 00:10:50,900
+وظيفياً، هي غير فاعلة وغير مسببة لمرض، يعني شغل
+
+106
+00:10:50,900 --> 00:10:58,180
+موجودة في الـ "DNA"، عشان نبين الاختلاف بين الـ
+
+107
+00:10:58,180 --> 00:11:02,720
+"DNA" تبع الأب من الأم، في جين معين، في مكان معين، وليس
+
+108
+00:11:02,720 --> 00:11:07,480
+بالضرورة أن ينتج عنها اختلال في وظيفة أو شكل أو
+
+109
+00:11:07,480 --> 00:11:12,780
+تركيب البروتين الناتج، إن شاء الله أن الأمر واضح
+
+110
+00:11:16,540 --> 00:11:22,080
+دكتور، هي بتسأل برضه إنه يعني الفرق بين
+
+111
+00:11:22,080 --> 00:11:25,380
+الـ Mutation والـ Polymorphism هو النسبة؟
+
+112
+00:11:28,000 --> 00:11:36,580
+الاثنين تقريباً مترادفان، يعني نسب، تعتبر يعني
+
+113
+00:11:36,580 --> 00:11:42,280
+تعدد الصور، بافتراض إنه يعني مثلاً أنا في مكان
+
+114
+00:11:42,280 --> 00:11:46,720
+معين، عندي صورتين، ثلاثة بين البشر، ماشي؟ الطفرة
+
+115
+00:11:46,720 --> 00:11:51,400
+إذا في شيء كان الأصل يكون موجود، وبعدين صارت
+
+116
+00:11:51,400 --> 00:11:54,720
+تغيّر، اختلاف
+
+117
+00:11:55,130 --> 00:12:01,570
+بين الوالدين والابن أو البنت، يعني إنه تغيّر شيء صار
+
+118
+00:12:01,570 --> 00:12:08,470
+يتطور، لما نستخدم Polymorphism، يعني حتى يعرفوه
+
+119
+00:12:08,470 --> 00:12:15,790
+بشكل أكثر، بيقول إن نسبته كطفرة في المجتمع أو في
+
+120
+00:12:15,790 --> 00:12:20,890
+اللي عندهم القيام بالدراسة أكثر من 1%، يعني الأقل من
+
+121
+00:12:20,890 --> 00:12:25,190
+1% لا تُعتبر Polymorphism، يعني هيك مرات نعتبرها
+
+122
+00:12:25,190 --> 00:12:33,030
+بس الـ SNP يعني هو هنا ما ممكنش نعتبره Polymorphism
+
+123
+00:12:33,030 --> 00:12:38,150
+لجين معين، يعني، مع أنه كلمة Polymorphism داخل فيه
+
+124
+00:12:38,150 --> 00:12:47,110
+يعني، لأنه قد لا يكون دقيق، ماشي؟ أنا راحت صورتي
+
+125
+00:12:47,110 --> 00:12:55,240
+بصراحة، ما بعرفش أوي، بده أشوف وين أنا عشان… ما هو اسمه؟ المهم،
+
+126
+00:12:55,240 --> 00:13:00,320
+طبعاً برضه لسه يعني واضحة النقطة بالنسبة لها، بس
+
+127
+00:13:00,320 --> 00:13:05,460
+يعني بتقول إنه حتى الطفرات اللي بقطعة كبيرة زي
+
+128
+00:13:05,460 --> 00:13:09,440
+الـ Copy Number Variant، ممكن ما يكونش لها قيمة لو
+
+129
+00:13:09,440 --> 00:13:15,800
+كانت في الـ non-coding region، لما نخطط بالشكل الصحيح
+
+130
+00:13:15,800 --> 00:13:25,530
+طبعاً، وهذه يعني من الـ… نسميها من الظواهر اللي بتعطي
+
+131
+00:13:25,530 --> 00:13:33,050
+الإنسان خاصية أكثر، إنه الـ DNA عنده بيتحمل إنه
+
+132
+00:13:33,050 --> 00:13:40,510
+يكون هناك طفرات كثيرة، بس إذا في مكان مالوش قيمة،
+
+133
+00:13:40,510 --> 00:13:45,250
+صح، مش راح يكون له قيمة، الدكتورة أسماء برضه يعني
+
+134
+00:13:45,250 --> 00:13:49,610
+بتطلب إذا كان فيه ممكن شرح الـ Slide رقم 7، مش عارف
+
+135
+00:13:49,610 --> 00:13:53,810
+إيش قصدها في المحاضرة هذه، وصلت دكتور أنت للـ Slide
+
+136
+00:13:53,810 --> 00:14:01,650
+رقم 7 في المحاضرة؟ والله الـ Slide رقم 7 اللي هو
+
+137
+00:14:01,650 --> 00:14:03,710
+الـ Microarray
+
+138
+00:14:06,230 --> 00:14:11,190
+هذا ما نأخذه بتفاصيل، هذا ما نأخذه
+
+139
+00:14:11,190 --> 00:14:12,470
+بتفاصيل، هذا ما نأخذه
+
+140
+00:14:12,470 --> 00:14:12,550
+بتفاصيل، هذا ما نأخذه
+
+141
+00:14:12,550 --> 00:14:13,290
+بتفاصيل، هذا ما نأخذه
+
+142
+00:14:13,290 --> 00:14:14,490
+بتفاصيل، هذا ما نأخذه
+
+143
+00:14:14,490 --> 00:14:14,990
+بتفاصيل، هذا ما نأخذه
+
+144
+00:14:14,990 --> 00:14:15,050
+بتفاصيل، هذا ما نأخذه
+
+145
+00:14:15,050 --> 00:14:23,090
+بتفاصيل، هذا ما نأخذه
+
+146
+00:14:23,090 --> 00:14:35,750
+بتفاصيل
+
+147
+00:14:35,860 --> 00:14:42,080
+اللي بتدور على الخلل اللي أنا بتوقع يكون موجود،
+
+148
+00:14:42,080 --> 00:14:46,900
+ماشي؟ ربما مش قصدها عن الـ Slide هذه، تقصد الـ Slide
+
+149
+00:14:46,900 --> 00:14:51,300
+اللي بعدها كمان، هدول نفس الفكرة، يعني
+
+150
+00:14:51,300 --> 00:14:55,100
+الـ Microarrays،
+
+151
+00:14:55,100 --> 00:15:03,600
+ماشي؟ يعني هنا إذا أنا مش يعني أحكي لكم قصص، ماشي؟
+
+152
+00:15:04,330 --> 00:15:12,550
+في، أنا الفترة الأخيرة، التقيت بعائلة من إخواننا من
+
+153
+00:15:12,550 --> 00:15:19,530
+سوريا، لاجئين في الأردن، يعني فعندهم حالة، هجيب لكم
+
+154
+00:15:19,530 --> 00:15:27,150
+صورة أيديهم، وجريهم للمحاضرة الجاية، ماشي؟ عليهم يعني
+
+155
+00:15:27,150 --> 00:15:33,790
+شيء غريب جداً، أقرب شيء، وإذا حدا بينكم بيحاول يشوفه
+
+156
+00:15:34,230 --> 00:15:41,570
+اسمه "Infantile Digital Fibromatosis"، يعني عبارة
+
+157
+00:15:41,570 --> 00:15:46,930
+عن، خلّيني أنا أبعت لك الصورة يا دكتور أحمد على
+
+158
+00:15:46,930 --> 00:15:53,110
+الـ WhatsApp إليك، ماشي؟ إن شاء الله، ولما تيجي
+
+159
+00:15:53,110 --> 00:15:59,610
+أعرضها عندك بإذن الله تعالى، فهدول العائلة هذه
+
+160
+00:16:00,220 --> 00:16:05,620
+الوالد والوالدة، درجة أولى أقارب، ولاد عم، ولاد خالة
+
+161
+00:16:05,620 --> 00:16:11,380
+يعني فيه قرابة، والشغل
+
+162
+00:16:11,380 --> 00:16:19,900
+الثاني، أنه عبارة عن، هم تسعة إخوة وإخوات، أربعة
+
+163
+00:16:19,900 --> 00:16:29,730
+مصابين، وأربعة مش مصابين، ماشي؟ فهَبعت لك الصور أنت
+
+164
+00:16:29,730 --> 00:16:38,410
+تُدخلهم للشباب والدكتورات، فالآن
+
+165
+00:16:38,410 --> 00:16:46,330
+أنا شاكك بشكل كبير جداً أن هذا مرض وراثي، وأشك أنه
+
+166
+00:16:46,330 --> 00:16:57,390
+يعني، إذا كان منديلي، يعني كان ناتج عن خلل في جين
+
+167
+00:16:57,390 --> 00:17:04,470
+واحد، ماشي؟ بيكون autosomal
+
+168
+00:17:04,470 --> 00:17:10,030
+dominant، لأن الذكور والإناث زي بعض، ما في اختلافات
+
+169
+00:17:10,030 --> 00:17:20,090
+بينهم، والشغل الثاني أنه الكل، يعني الـ… الـ… الـ…
+
+170
+00:17:20,090 --> 00:17:24,390
+بالنسبة للـ… أنه كل الأفراد، يعني فيه ذكور وفيهم
+
+171
+00:17:24,390 --> 00:17:31,370
+إناث، ومن العائلة بالكامل، فيه ناس فيهم مصابين، ففي
+
+172
+00:17:31,370 --> 00:17:38,210
+مثل هيك حالة، شاورت مع قسم الأمراض الوراثية عندنا
+
+173
+00:17:39,120 --> 00:17:47,020
+المشكلة أنه أنا ما عندي تخيل سابق، لوين أنول الجين
+
+174
+00:17:47,020
+
+223
+00:22:20,420 --> 00:22:29,180
+الثاني اللي صار حجمه أكبر فهذه الظاهرة هي تسمى الـ
+
+224
+00:22:29,180 --> 00:22:36,810
+Balanced Translocation يعني اختلال في مكان القطعة
+
+225
+00:22:36,810 --> 00:22:46,170
+الكبيرة بحيث أنه بالمحصلة المادة الوراثية تبع هذا
+
+226
+00:22:46,170 --> 00:22:52,550
+الإنسان بتكون كاملة، بتكون طبيعية، الـTotal طبيعي،
+
+227
+00:22:52,550 --> 00:23:01,890
+بس مكانه غلط، فلما يكون وجود Balanced Translocation
+
+228
+00:23:01,890 --> 00:23:11,630
+ماشي، هذه بتكون نتيجتها أن نفس الشخص هذا بيكون طبيعي
+
+229
+00:23:11,630 --> 00:23:19,670
+بس أنه بالنسبة للـ بروجينيته، ولاده وبناته
+
+230
+00:23:19,670 --> 00:23:26,450
+بعدين راح تصير فيه إشكاليات، أنه لما يصير الخلايا
+
+231
+00:23:26,450 --> 00:23:30,050
+المطلوبة منها تنقص بشكل سليم، في بعض الخلايا راح
+
+232
+00:23:30,050 --> 00:23:36,530
+تكون عندها DNA ناقص، ويمكن هذا يكون غير حي ولا يعيش
+
+233
+00:23:36,530 --> 00:23:41,250
+وإنه يكون فيه إيش زايد، يكون يعطينا مرض. هاي قضية
+
+234
+00:23:41,250 --> 00:23:45,610
+الـ Structural Abnormalities، وهمية أن تكون Balanced
+
+235
+00:23:45,610 --> 00:23:50,470
+أو Unbalanced، وكيف تأثيرها. الشغل الثاني الـ
+
+236
+00:23:50,470 --> 00:23:56,610
+Unbalanced يعني اختلال عدد نسخ وكمية
+
+237
+00:23:56,610 --> 00:24:01,550
+الـ Chromosomes اللي هي راح نحكي عنها، عملية عدم
+
+238
+00:24:01,550 --> 00:24:07,710
+انصال الـ Chromosomes عن بعض بشكل سليم، وبالذات هي
+
+239
+00:24:07,710 --> 00:24:11,930
+أكثر للـ XY-Chromosome، بس ممكن حتى في
+
+240
+00:24:11,930 --> 00:24:17,690
+الـ Chromosomes الثانية. في أسئلة هنا؟
+
+241
+00:24:17,690 --> 00:24:24,450
+ليستة أرجو أنكم تحفظوها. يعني لما تيجي تقرأ، وبعدين
+
+242
+00:24:27,860 --> 00:24:35,400
+التقارير عن أي مرض وتحاولوا تفهموا شو اللي بيحكوا
+
+243
+00:24:35,400 --> 00:24:40,060
+عنه كحدث اللي حصل على مستوى المادة الوراثية والـ
+
+244
+00:24:40,060 --> 00:24:47,180
+DNA، وكيف صار. فإذا كتبوا الديل "Deletion"، إذا كان
+
+245
+00:24:47,180 --> 00:24:51,540
+حاطين إشارة زائد، فإنه صار زيادة في الوظيفة أو
+
+246
+00:24:51,540 --> 00:24:58,120
+نقصان في الوظيفة، أو هناك يعني في نفس الجسم خلايا
+
+247
+00:24:58,120 --> 00:25:02,560
+بتكون بشكل، وخلايا ثانية بتكون بشكل آخر، إنه بيكون
+
+248
+00:25:02,560 --> 00:25:09,020
+فعلاً موزائيكزم، موزائيك ماشي، اللي هي إنه يعني زي الـ
+
+249
+00:25:11,210 --> 00:25:16,310
+الأنظمة أو الشكل، إنه بيكون من أكثر من نوع، مثلاً من
+
+250
+00:25:16,310 --> 00:25:21,990
+بلاط لون معين وبلاط لون ثاني مثلاً. قضية الـ
+
+251
+00:25:21,990 --> 00:25:26,550
+Translocation، روبرتسونيان Translocation، Rain
+
+252
+00:25:26,550 --> 00:25:30,890
+Chromosome. يعني الأشياء اللي موجودة هذه، جدول
+
+253
+00:25:32,000 --> 00:25:39,080
+كمصطلحات، لأ مهم، وكويس الواحد يفهمه، عشان لما نقرأ
+
+254
+00:25:39,080 --> 00:25:45,260
+يعني هنا كمثال، لكل واحد منهم شو معناه، وشو بيدل على
+
+255
+00:25:45,260 --> 00:25:54,580
+إيش، أن نكون بذلك الشكل. هاي كمان يعني أسلوب، يعني
+
+256
+00:25:54,580 --> 00:26:03,070
+لما يحطوا لنا رسمات زي هيك، ماشي، هو بيحط نماذج مختلفة
+
+257
+00:26:03,070 --> 00:26:11,750
+للتجارب المخبرية، لتشخيص هذه الحالة. فالـ Trisomy 21
+
+258
+00:26:11,750 --> 00:26:19,170
+اللي هو Down Syndrome، ماشي. الـ Trisomy 21 ممكن
+
+259
+00:26:19,170 --> 00:26:25,690
+أنا في الـ A حطيت اللي هو Karyotype، فأنا بشغله
+
+260
+00:26:25,690 --> 00:26:33,220
+بهذا الشكل، هذه كريوتيب، وبيكون فيه ترايسومي 21، ممكن أنا
+
+261
+00:26:33,220 --> 00:26:39,280
+أستخدم الـ Fluorescence in situ hybridization، اللي هي Fluorescence
+
+262
+00:26:39,280 --> 00:26:45,720
+in situ Hybridization for Chromosome 21، ويعني هنا
+
+263
+00:26:45,720 --> 00:26:51,360
+بيطلع ليه، إن أنا عندي تلت نسخة، ماشي، يعني يمكن هو
+
+264
+00:26:51,360 --> 00:26:56,960
+الأحمر، فبكون إنه في هذه الخلية بيكون عندي ثلاث نسخ
+
+265
+00:26:56,960 --> 00:27:00,980
+من هذا الأحمر. كروموزوم ثاني، عشان أتأكد إن أنا شغلي
+
+266
+00:27:00,980 --> 00:27:07,700
+مظبوط، خطيت عليه صبغة خضراء، وبالتالي بين عندي إن
+
+267
+00:27:07,700 --> 00:27:12,520
+أنا في نسختين. أنا مش، أنا بالغلط صار Overlap بين
+
+268
+00:27:12,520 --> 00:27:18,440
+خليتين، وفي حالة إنه عندي أنا أكثر من نصف، يعني
+
+269
+00:27:18,440 --> 00:27:24,850
+من زيادة من خلية أكثر من خلية. فهنا، هاي نوع من الـ
+
+270
+00:27:24,850 --> 00:27:29,250
+FISH، اللي هو in situ Hybridization، بنستخدم تقنيات
+
+271
+00:27:29,250 --> 00:27:36,350
+مختلفة. اللي بعدها، اللي دلوقت يقرا اللي هو
+
+272
+00:27:36,350 --> 00:27:39,470
+Chromosomal
+
+273
+00:27:39,470 --> 00:27:44,750
+Microarray واستخدام
+
+274
+00:27:44,750 --> 00:27:49,790
+يعني اللي هو الـ Microarrays، اللي هي الأسلوب الثالث
+
+275
+00:27:51,810 --> 00:28:00,170
+بشوف هنا الكروموزومات تبع الإنسان، والأصل اللي هي
+
+276
+00:28:00,170 --> 00:28:07,530
+2M، يعني النسختين من الـ من الـ الـ DNA، ولا
+
+277
+00:28:07,530 --> 00:28:11,930
+الكروموزوم، بتكون في هذا النطاق. حسب هذا البحث، بلاقي
+
+278
+00:28:11,930 --> 00:28:19,430
+هنا الكروموزوم 21 عالي كثير، وعرفت أنه يعني ثلاث نسخ
+
+279
+00:28:19,430 --> 00:28:24,570
+بدل ما هو من نسختين، العادي. لو كان فيه مثلاً نفترض
+
+280
+00:28:24,570 --> 00:28:30,810
+أنا شخص بـ "تيرنر سندروم"، ما بتعرفوا عنه، بيكون XO
+
+281
+00:28:30,810 --> 00:28:34,610
+بيكون "one copy of X". باجي لو باجي بعمل
+
+282
+00:28:34,610 --> 00:28:38,410
+الـ microarray هذا، باستخدمه للـ X-Chromosome، كان
+
+283
+00:28:38,410 --> 00:28:43,580
+بلاقي الطفل هذا أو الإنسان هذا، بيجي بروح، بتلاقي إذا
+
+284
+00:28:43,580 --> 00:28:47,720
+كان فوق معناته زيادة، إذا كان تحت معناته فيه نقص
+
+285
+00:28:47,720 --> 00:28:55,960
+فهي الفكرة هنا كله لنفس التشخيص، لنفس الظاهرة، ولكن
+
+286
+00:28:55,960 --> 00:29:03,680
+باستخدام وسائل مخبرية مختلفة. يعني كل واحد منهم إيه
+
+287
+00:29:03,680 --> 00:29:07,900
+إيجابياته وإيه سلبياته، إيه نقاط قوته، بس فيه إيه نقاط
+
+288
+00:29:07,900 --> 00:29:12,680
+ضعف. ضروري الواحد ينتبه لهذه الأشياء، لما يفكر كيف
+
+289
+00:29:12,680 --> 00:29:22,480
+يشخص هذه الحالة. في أسئلة؟ لأن نوعيات الـ
+
+290
+00:29:22,480 --> 00:29:29,920
+Translocation وأنواعها، Balanced و Unbalanced، وبكون
+
+291
+00:29:29,920 --> 00:29:37,380
+في، ومكان بين كذا وكذا. يعني هذه الظواهر تحدث
+
+292
+00:29:38,300 --> 00:29:45,240
+فيه ظواهر موجودة، وأحيانًا يعني في حالات معينة
+
+293
+00:29:45,240 --> 00:29:52,440
+بيكون فيها حتى دور وظيفي للمرض اللي بنشوفه
+
+294
+00:29:52,440 --> 00:29:59,660
+يعني مثلاً المرض من أنواع السرطانات اللي هو
+
+295
+00:29:59,660 --> 00:30:06,260
+"Chronic Myeloid Leukemia"، الـ "CML". الـ "CML" من
+
+296
+00:30:06,260 --> 00:30:10,750
+الأشياء المميزة له، اللي هي موضوع بيسموه الـ
+
+297
+00:30:10,750 --> 00:30:13,750
+Philadelphia chromosome، الـ Philadelphia
+
+298
+00:30:13,750 --> 00:30:19,630
+chromosome، عبارة عن Translocation
+
+299
+00:30:19,630 --> 00:30:27,330
+بين قطعتين من الـ DNA، بحيث أنه في الـ PCR اللي هو
+
+300
+00:30:27,330 --> 00:30:32,570
+الـ B cell receptor gene، يعني عبارة عن مكان معين
+
+301
+00:30:32,570 --> 00:30:37,230
+في الخلايا الليمفاوية. الخلايا الليمفاوية، بس إله
+
+302
+00:30:37,230 --> 00:30:44,600
+دخل في بقاء الخلايا ومعيشة الخلايا وحياة الخلايا
+
+303
+00:30:44,600 --> 00:30:51,340
+منعها من إنها تتوفى بالـ Apoptosis، وفي الـ ABL-Gene
+
+304
+00:30:51,340 --> 00:30:56,020
+اللي دخل في الـ Longevity تبعته. فهدول الأصل قطعتين
+
+305
+00:30:56,020 --> 00:30:59,840
+في الـ DNA، بعاد عن بعض، ولما ييجي في الـ
+
+306
+00:30:59,840 --> 00:31:02,340
+Philadelphia chromosome، أو في اللي عندهم هذه الـ
+
+307
+00:31:02,340 --> 00:31:06,440
+Genetic Mutation، بيصيروا جانب بعض، وبكون نتيجة
+
+308
+00:31:06,440 --> 00:31:13,110
+اختلال في وظيفة الخلية. فهذه كلها ظواهر، يعني أنا أظن
+
+309
+00:31:13,110 --> 00:31:22,750
+أنه الآن المطلوب الفهم العام، وليس المقصود التفاصيل
+
+310
+00:31:22,750 --> 00:31:28,950
+حدوث هذه الأشياء، لما يكون الـ Translocation
+
+311
+00:31:28,950 --> 00:31:35,390
+والاختلال. دلوقتي بقوله Balanced، البلاء أقل، المرض
+
+312
+00:31:35,390 --> 00:31:42,330
+أخف، إنه على الأقل هذا الإنسان عنده كمية DNA كافية
+
+313
+00:31:42,330 --> 00:31:49,470
+وطبيعية ومتوقعة، بس وين تواجدها، شرط تلتحم مع بعض
+
+314
+00:31:49,470 --> 00:31:54,670
+كيف علاقتها في بعض، هو اللي بيصير فيه خلافات، وهذه راح
+
+315
+00:31:54,670 --> 00:31:58,450
+تنتج عندها مشاكل في الذرية تبع هذا الإنسان، في
+
+316
+00:31:58,450 --> 00:32:07,590
+ولاده وبناته. هنا دراسة، يعني مهم الواحد يتطلع
+
+317
+00:32:07,590 --> 00:32:15,450
+عليها، ويكون يتخيلها، على نسبة احتمالات الأمراض
+
+318
+00:32:15,450 --> 00:32:22,210
+الوراثية، اللي هي الـ Whole Genome أو Whole
+
+319
+00:32:22,210 --> 00:32:26,490
+Chromosome الدراسة
+
+320
+00:32:26,490 --> 00:32:33,010
+هذه على 10,000 حالة ولادة، ماشي؟
+
+321
+00:32:36,020 --> 00:32:40,660
+ويعني حاطين هنا، زي ما ذكرت، أكثر شوية من المرة اللي
+
+322
+00:32:40,660 --> 00:32:45,360
+فاتت، الـ Spontaneous Abortion والـ Live Born
+
+323
+00:32:45,360 --> 00:32:52,380
+Infant. يعني الإثنين، لو صار Abortion، بيقضوا يدرسوا
+
+324
+00:32:52,380 --> 00:32:56,340
+كيف وضع الـ Karyotype، شو اللي نوع المشكلة
+
+325
+00:32:56,340 --> 00:33:03,700
+الموجودة، أو حدوث إجهاض ذاتي
+
+326
+00:33:03,700 --> 00:33:08,520
+spontaneous، الآن
+
+327
+00:33:08,520 --> 00:33:13,480
+نشوف كم نسب الاختلالات في الـ Chromosomes كلها
+
+328
+00:33:13,480 --> 00:33:20,020
+فهنا أنا استخدمت اللي هو بين قوسين الـ Karyotype
+
+329
+00:33:20,020 --> 00:33:28,340
+يعني حتى أطلع مثل إيه نتاج الحالات
+
+330
+00:33:28,340 --> 00:33:33,440
+اللي عملوها الدراسة هذه، العشر آلاف، كان 1500
+
+331
+00:33:33,440 --> 00:33:40,940
+abortion، 15%، و8500 يعني 85% live birth
+
+332
+00:33:44,320 --> 00:33:50,120
+بالنسبة للـ Live Births من الـ 8500، فيه خمسين كان
+
+333
+00:33:50,120 --> 00:33:54,220
+عندهم كروموزوم Anomalous، بينما بالـ
+
+334
+00:33:54,220 --> 00:34:00,660
+Spontaneous Abortions، 750 من الـ 1500 كان عندهم
+
+335
+00:34:00,660 --> 00:34:09,880
+Abnormal Chromosome. يعني بالذات في عند حدوث
+
+336
+00:34:09,880 --> 00:34:16,500
+الإجهاض الذاتي للمرأة الحامل، في الأشهر الأولى، نتكلم
+
+337
+00:34:16,500 --> 00:34:22,220
+حتى غالبًا أول ثلاث أشهر، هذه راح يكون في الغالب في
+
+338
+00:34:22,220 --> 00:34:29,720
+أنها Abnormal chromosomal defect، يعني مشكلة كبيرة
+
+339
+00:34:29,720 --> 00:34:36,880
+بالنسبة لكمية كبيرة من الـ DNA، وهذه يعني حتى لو
+
+340
+00:34:36,880 --> 00:34:42,920
+صار Live birth، ممكن أحيانًا يكون في نسبة من أمراض
+
+341
+00:34:42,920 --> 00:34:48,940
+مثل ذلك. الآن، ما هي أنواع المشاكل اللي بتوقع الواحد
+
+342
+00:34:48,940 --> 00:34:54,020
+أو اللي لقوها في الدراسة؟
+
+343
+00:34:54,020 --> 00:35:01,740
+يعني، مع الـ Abortion، 800 حالة Total من الـ 10,000
+
+344
+00:35:01,740 --> 00:35:06,620
+pregnancies، يعني 8% كان فيهم الـ Chromosomal
+
+345
+00:35:06,620 --> 00:35:11,040
+Anomalies. يعني نسبة محرزة فيه Triploid و
+
+346
+00:35:11,040 --> 00:35:17,180
+Tetraploid. يعني إحنا الأصل للإنسان إن الخلايا
+
+347
+00:35:17,180 --> 00:35:26,440
+التابعة لنا فيها 46، زوج ماشي، يعني 23 زوج، 46
+
+348
+00:35:26,440 --> 00:35:38,780
+كروموزوم. الـ Triploid يعني يطلع اللي هو 23×3
+
+349
+00:35:38,780 --> 00:35:46,270
+بيصير إنها 69 كروموزوم، بحيث أنه يكون ثلاث نسخ
+
+350
+00:35:46,270 --> 00:35:51,970
+وTetraploid يعني أنه ضرب بأربعة، 23×4
+
+351
+00:35:51,970 --> 00:35:59,170
+يعني بيصير 92 chromosome موجود في الخلايا، فهي حدوث
+
+352
+00:35:59,170 --> 00:36:05,370
+مثل ذلك، اختلال شديد، ظاهرة موجودة في الـ abortion
+
+353
+00:36:05,370 --> 00:36:11,450
+اللي بيكمل الحمل ما بيكون محتمل أن يكون عنده مثل
+
+354
+00:36:11,450 --> 00:36:20,370
+ذلك. ظاهرة متوقعة تكون موجودة في الوفيات أو الـ
+
+355
+00:36:20,370 --> 00:36:26,010
+spontaneous abortions، والإجهاضات كان
+
+356
+00:36:26,010 --> 00:36:34,190
+فيه 140 Turner، اللي هو XO، بس نصها واحدة من الـ X
+
+357
+00:36:34,190 --> 00:36:40,650
+مافيش Y أو X ثانية. وبالنسبة للـ Live Births كان فيه
+
+358
+00:36:40,650 --> 00:36:46,420
+احتمالية واحدة، يعني من 10,000 pregnancies، بتوقع
+
+359
+00:36:46,420 --> 00:36:57,020
+الواحد، واحد Turner يكون يعني موجود، يعني. فطلعت
+
+360
+00:36:57,020 --> 00:37:02,540
+الـ slide، دكتورة
+
+361
+00:37:02,540 --> 00:37:05,580
+اسمها، إذا بتسأل، ممكن توضيح لظاهرة
+
+362
+00:37:05,580 --> 00:37:11,700
+الـ Isochromosome، عبارة عن إيش هي بتطلع؟ من إيش، قديم
+
+363
+00:37:11,700 --> 00:37:14,840
+ولا فيها في الـ سلايد؟ لأ، أعتقد في الـ سلايد
+
+364
+00:37:14,840 --> 00:37:25,280
+السابق، يعني "ظاهرة الـ Isochromosome". الأسئلة
+
+365
+00:37:25,280 --> 00:37:30,360
+دا فيها، أي واحد عنده سؤال يوقف وقتها، شايف عليه؟
+
+366
+00:37:30,360 --> 00:37:40,310
+يعني الـ "انفرجل لوبز" والأشكال الأخرى من الـ أشكال
+
+367
+00:37:40,310 --> 00:37:45,550
+شكل الكروموزوم وارتباطاتهم مع بعض، اللي هم أكثر من
+
+368
+00:37:45,550 --> 00:37:52,050
+شكل ودولة، يعني خلينا اليوم نوقفهم على إنهم أمثلة
+
+369
+00:37:52,050 --> 00:37:59,310
+للاختلالات اللي ممكن تحدث، تفاصيل ليش حدثت وكذا
+
+370
+00:37:59,310 --> 00:38:05,690
+اليوم، والآن إذا ما إلها نصيب بعدين نرجحها في مرض
+
+371
+00:38:05,690 --> 00:38:11,380
+معين، أو إذا نتناقش عن حالة معينة. ماشي، ما بديش
+
+372
+00:38:11,380 --> 00:38:17,140
+أدخل فيها. يعني الآن هذه الأشياء اللي هنا، يعني الظواهر
+
+373
+00:38:17,140 --> 00:38:25,140
+في اختلال التركيب تبع الـ DNA، كـ Chromosome، كشكل
+
+374
+00:38:25,140 --> 00:38:31,320
+كله. إذا الاختلال، بالأخير كمية الـ DNA، Balance
+
+375
+00:38:31,320 --> 00:38:36,940
+متوازنة مع الطبيعي، بالغالب نفس الشخص ما عنده
+
+376
+00:38:36,940 --> 00:38:43,070
+مشكلة، بس بتسوي مشاكل في ذريته، لأنه بتـرجع الخلايا
+
+377
+00:38:43,070 --> 00:38:46,670
+بده لازم تتقسم بالنصف مظبوط، فبيصير فيه جزء وفي
+
+378
+00:38:46,670 --> 00:38:52,430
+زيادة، وفي جزء وفي نقصان. يعني هنا الـ هاي
+
+379
+00:38:52,430 --> 00:38:58,310
+أمثلة على الأشياء اللي ممكن تحدث. الأمثلة
+
+380
+00:38:58,310 --> 00:39:03,230
+على اللي الآن بنحكيها، وصلت أنا للـ 45, XO، اللي هو
+
+381
+00:39:03,230 --> 00:39:12,120
+الـ Turner هذا. يعني فيه خلل، وفيه مرض، وفيه عدم نمو طبيعي
+
+382
+00:39:12,120 --> 00:39:20,920
+ومشاكل كثيرة، بس بيظل أنه يعني بالذات لأن الـ Y
+
+383
+00:39:20,920 --> 00:39:25,840
+-Chromosome مش مهم كثير، كان خواص للحياة كثيرة
+
+384
+00:39:25,840 --> 00:39:31,500
+وكذلك الـ X الثاني أصلاً بتأثر نصهم في نفس الخلايا
+
+385
+00:39:31,500 --> 00:39:34,980
+أو اللي هي الـ Ionization اللي إحنا نحكي عنه، فهو
+
+386
+00:39:34,980 --> 00:39:39,020
+يعتبر شيء خفيف. يعني هو أشياء واحدة، في مرات بيكون
+
+387
+00:39:39,020 --> 00:39:47,020
+ممكن أنه يكون الإنسان يكمل، لأنه يتم ولادته. "Trisomy
+
+388
+00:39:47,020 --> 00:39:54,120
+16" و"Trisomy 18" بتحدث بنسبة أكبر بكثير بالـ
+
+389
+00:39:54,120 --> 00:40:01,160
+Abortion، لأنها غير يعني متوافقة مع الحياة، بس ممكن
+
+390
+00:40:01,160 --> 00:40:05,660
+يصل إنه طفل يولد فيها، بس ما بيطولش بعدها يعني
+
+391
+00:40:05,660 --> 00:40:10,840
+"Trisomy 21" راح ناخد عنه بعدين، اللي هو Down
+
+392
+00:40:10,840 --> 00:40:16,390
+Syndrome، وفيه ممكن Other Types of Trisomy، فيه الـ...
+
+393
+0
+
+445
+00:45:02,980 --> 00:45:07,740
+المناسب خاضع للطبيعة، ماشي؟
+
+446
+00:45:07,740 --> 00:45:16,160
+فالآن اليوم راح نتكلم عن الـChromosomal Genomic Basis
+
+447
+00:45:16,160 --> 00:45:20,540
+of Disorders of the Autosomes and Sex Chromosomes
+
+448
+00:45:20,540 --> 00:45:25,580
+يعني نرجع مرة ثانية، نرجع
+
+449
+00:45:25,580 --> 00:45:30,080
+مرة ثانية لأشياء
+
+450
+00:45:30,080 --> 00:45:36,060
+القريبة اللي أخذناها منها، يعني اللي هو من الـslide
+
+451
+00:45:36,060 --> 00:45:40,200
+الأخير، الـ
+
+452
+00:45:42,020 --> 00:45:50,960
+النقطة الأولى، ماشي، ليش؟ يعني وين الإشكالية حتى
+
+453
+00:45:50,960 --> 00:45:55,640
+تحدث مثل هذه الأشياء؟ أن يصير عندي خلل في عدد
+
+454
+00:45:55,640 --> 00:46:04,940
+الكروموزومات أو خلل في وجودها، وكذا أهم واحد أنا
+
+455
+00:46:04,940 --> 00:46:08,380
+بعتبره، يعني على الأقل هيك للواحد حتى يفهمها، اللي
+
+456
+00:46:08,380 --> 00:46:12,670
+هي Abnormal Chromosomal Segregation، يعني الـ Non
+
+457
+00:46:12,670 --> 00:46:21,170
+-Disjunction. يعني الفكرة هنا إنه أنا في ظاهرة
+
+458
+00:46:21,170 --> 00:46:26,610
+انقسام الخلية، حكينا على إنه بالـ Metaphase لازم
+
+459
+00:46:26,610 --> 00:46:34,570
+بالنصف، في المستوى المنصف للخلية، تيجي الكروموزومات
+
+460
+00:46:34,570 --> 00:46:42,230
+كلها بتصف جنب بعض، كل اثنين مقابل بعض، مظبوطات، وفيه
+
+461
+00:46:42,230 --> 00:46:48,950
+Central Zones على الطرفين، وفيه قيوط الـ Spindle
+
+462
+00:46:48,950 --> 00:46:57,370
+Fibers اللي هي زي العضلات بتجذب القطعتين هدول
+
+463
+00:46:57,370 --> 00:47:06,210
+للطرفين، ماشي؟ يعني هو اللي بتكلموا عنه، إذا لسبب
+
+464
+00:47:06,210 --> 00:47:14,440
+ما كان عدم انفصال نظيف، كامل، سليم بين الـTwo
+
+465
+00:47:14,440 --> 00:47:18,740
+copies، راح يصير عندي ما يسمونه «non-disjunction»
+
+466
+00:47:18,740 --> 00:47:24,340
+يعني إنه ما انفصلوش عن بعض بشكل سليم، راح يكون عندي
+
+467
+00:47:24,340 --> 00:47:29,360
+نتيجة هذا الأمر، يا إما الاثنين كلهم يروحوا على
+
+468
+00:47:29,360 --> 00:47:33,180
+الجهة الواحدة، وبالتالي الجهة الثانية، يعني الـTwo
+
+469
+00:47:33,180 --> 00:47:36,810
+copies كلهم يروحوا الجهة الواحدة، والجهة الثانية ما
+
+470
+00:47:36,810 --> 00:47:40,570
+راح يروح لها شيء من هذا الـ set من الـ
+
+471
+00:47:40,570 --> 00:47:47,270
+Chromosomes، أو أن أحياناً أنه يعني واحد ونصف يروح
+
+472
+00:47:47,270 --> 00:47:55,350
+هذه الجهة، ونصف يروح هناك، ماشي؟ نتيجة هذا الأمر، يعني
+
+473
+00:47:55,350 --> 00:48:04,170
+راح يكون Unequal، يعني تغير في العدد، ماشي،
+
+474
+00:48:04,170 --> 00:48:07,830
+زي الـDown Syndrome، الـKlinefelter، وReversible
+
+475
+00:48:07,830 --> 00:48:14,210
+Dysentery، وأشياء، يعني من الأمثلة على الأمراض، إنه
+
+476
+00:48:14,210 --> 00:48:20,090
+تكون عندي يا إما زيادة يا إما نقص. Recurrent
+
+477
+00:48:20,090 --> 00:48:24,290
+chromosomal syndromes، Dyadic chromosomal anomalies،
+
+478
+00:48:24,290 --> 00:48:27,790
+Unbalanced familial anomalies، Abnormalities،
+
+479
+00:48:27,790 --> 00:48:32,390
+Syndromes، Endowing Genetic Genomic Imprinting.
+
+480
+00:48:32,810 --> 00:48:43,070
+الباقية ما بدّي، يعني يعني ما بدّي، مش مهم كثير أحفظ
+
+481
+00:48:43,070 --> 00:48:48,630
+وأفهم ليش بتصير وكيف بتصير وكذا، يعني حكينا قبل
+
+482
+00:48:48,630 --> 00:48:54,030
+شوية عن إنه إذا في balanced translocation موجود في
+
+483
+00:48:54,030 --> 00:49:00,460
+شخص معين، هذا رح يعمل مشكلة ويكون في الـ الـ
+
+484
+00:49:00,460 --> 00:49:05,640
+Progeny، الذرية تبع هذا الإنسان نفسه، هو ممكن ما
+
+485
+00:49:05,640 --> 00:49:09,800
+يظهر عليه أي مرض، ما يكون فيه مشكلة، حسب طبيعة
+
+486
+00:49:09,800 --> 00:49:15,240
+الخلل، طبيعة الانتقال، طبيعة الارتباط، البعض بنتج
+
+487
+00:49:15,240 --> 00:49:21,560
+عنه، راح نحكي على أمراض ومشاكل وأنواع من المشاكل
+
+488
+00:49:21,560 --> 00:49:27,480
+التالية، بس بظل، يعني أنا أظن الأسهل، وفينا، يعني في
+
+489
+00:49:27,480 --> 00:49:32,810
+أمراض كثيرة مشهورة، أو واحدة الميزة، إذا شاف مريض مثل
+
+490
+00:49:32,810 --> 00:49:35,910
+هذا النوع، اللي هي الـNon-disjunction، اللي هي
+
+491
+00:49:35,910 --> 00:49:39,870
+الـAbnormal Chromosomal Segregation، هذه
+
+492
+00:49:39,870 --> 00:49:50,710
+الـMechanisms، واللي نتكلم عنه هي النوعية الأكبر أو
+
+493
+00:49:50,710 --> 00:49:54,190
+نوعية  قطع الكروموزومات الأكبر، اللي هي
+
+494
+00:49:54,190 --> 00:50:02,280
+الـChromosomal Anomalies. بذكر مرة ثانية، تذكروا إنه
+
+495
+00:50:02,280 --> 00:50:06,920
+إحنا في تعاملنا مع الأمراض الوراثية، لازم هيك أحطها
+
+496
+00:50:06,920 --> 00:50:11,900
+بين ثلاث أنواع: يا إما شيء في الـ Chromosome كله
+
+497
+00:50:11,900 --> 00:50:17,980
+وهي اللي راح نتكلم عنها، يا إما Mendelian، اللي هي
+
+498
+00:50:17,980 --> 00:50:22,140
+Single Nucleotide، Single Gene، Single Protein،
+
+499
+00:50:22,140 --> 00:50:30,400
+متخصصة إلى قواعد الوصول ومبادئ، وفي المجموعة الثالثة
+
+500
+00:50:30,400 --> 00:50:34,780
+اللي هي اللي بيسموها Polygenic، اللي هي بتكون أكثر
+
+501
+00:50:34,780 --> 00:50:38,660
+من جين بيستخدمها، وهنا اللي نحن نتكلم عنه
+
+502
+00:50:38,660 --> 00:50:44,820
+Epigenetic Control، الـGenetic Imprinting، المشغلات
+
+503
+00:50:44,820 --> 00:50:50,140
+الـDNA Methylation، الـHistone Methylation، الـMicro
+
+504
+00:50:50,140 --> 00:50:55,040
+RNA Anomalies أو Changes. فيه لها Mechanisms كثيرة
+
+505
+00:50:55,040 --> 00:51:01,520
+تتدخل بعدين، بتشارك، إنه الخلل أو الاختلاف يكون فيه
+
+506
+00:51:01,520 --> 00:51:07,260
+عدد كبير من الجينات بطريقة مختلفة تتحكم في وظيفة
+
+507
+00:51:07,260 --> 00:51:11,780
+الـChromosome، أو وظيفة الـDNA، أو وظيفة البروتينات.
+
+508
+00:51:11,780 --> 00:51:15,160
+فحنا اليوم والآن على الـChromosome، الـAutosomal
+
+509
+00:51:15,160 --> 00:51:18,860
+المجموعة
+
+510
+00:51:18,860 --> 00:51:25,030
+الأولى، اللي هو يعني دائماً مش غلط الواحد يتذكر اللي
+
+511
+00:51:25,030 --> 00:51:33,330
+هم الـDowns اللي هم المهم الواحد يعرف فضيّة اللي هي
+
+512
+00:51:33,330 --> 00:51:38,790
+الـCommon things are common، أشياء شائعة شائعة
+
+513
+00:51:38,790 --> 00:51:43,150
+وبالتالي، يعني هو اللي لازم يقدر يميزها بسرعة
+
+514
+00:51:43,150 --> 00:51:50,520
+وينتبه عليها ويتعامل معاها. الـ Trisomy 21، والأنواع
+
+515
+00:51:50,520 --> 00:51:57,120
+الثانية 18 و13، اللي هي مثلًا Patau Syndrome، Edwards Syndrome
+
+516
+00:51:57,120 --> 00:52:02,000
+أو الـ Edwards Syndrome،  إلخ.  إلخ.
+
+517
+00:52:02,000 --> 00:52:10,350
+ثاني، ثاني، لأ الوضع أسوأ بكثير، ماشي، وكلهم ما بيعيشوا،
+
+518
+00:52:10,350 --> 00:52:14,750
+بيموتوا بسرعة، ولادات، يعني بعد الولادة بسرعة، وفيه
+
+519
+00:52:14,750 --> 00:52:17,770
+severe mental retardation، severe heart
+
+520
+00:52:17,770 --> 00:52:25,310
+malformation، كذا، بتلاقي فيه مشاكل كبيرة. الـ Down
+
+521
+00:52:25,310 --> 00:52:30,770
+Syndrome مشهور ومعروف، لما كنت طالب كنا هيك نتحدى
+
+522
+00:52:30,770 --> 00:52:36,790
+بعض حتى الواحد يذكرها، كنا نقول فيه 30 characteristic
+
+523
+00:52:36,790 --> 00:52:42,690
+موجودة في الـ Down Syndrome. فنتبهوا هنا: Hypotonia،
+
+524
+00:52:42,690 --> 00:52:47,670
+يعني الشدّة
+
+525
+00:52:47,670 --> 00:52:55,130
+العضلات، قوة العضلات، فيها رخاوة يعني، فـHypotonia،
+
+526
+00:52:55,130 --> 00:53:01,290
+Short Stature، الطول القصير، Loose Skin on the
+
+527
+00:53:01,290 --> 00:53:07,610
+nape، اللي هو يعني على الـ .. يعني في أسفل الظهر أو
+
+528
+00:53:07,610 --> 00:53:12,410
+في أسفل الرقبة. الـ Palmer crease، إحنا الأيدين
+
+529
+00:53:12,410 --> 00:53:16,130
+الواحدة، دي كده بتطلع عليها، فيه الفنتان اللي تشوفه
+
+530
+00:53:16,130 --> 00:53:20,350
+واحد عنده Down Syndrome، مثلها كخط واحد. Palmer
+
+531
+00:53:20,350 --> 00:53:26,140
+crease، وclinodactyly، فيه خلل في الأصابع. الـ Flat
+
+532
+00:53:26,140 --> 00:53:36,020
+Occipital، يعني المؤخرة، الرأس مش مستديرة، هيك مسطحة
+
+533
+00:53:36,020 --> 00:53:40,960
+الـ Epicanthic Folds، اللي هي كما بيقولوا منغولية
+
+534
+00:53:40,960 --> 00:53:46,240
+يعني شبيهة بعيون المغول والصينيين، وGush fields اللي هي
+
+535
+00:53:46,240 --> 00:53:52,550
+حقيقة في الـmedial aspect of the eye، بتلاقي في الـ…
+
+536
+00:53:52,550 --> 00:53:58,370
+في الـ… يعني fold بطريقة معينة، هي اللي بتعطي
+
+537
+00:53:58,370 --> 00:54:03,570
+العيون زي الصينيين. يعني الـBrush field spots، حاطين
+
+538
+00:54:03,570 --> 00:54:08,150
+صورة لها. في moderate to mild، أحياناً severe
+
+539
+00:54:08,150 --> 00:54:13,050
+intellectual disability، التخلف العقلي. congenital
+
+540
+00:54:13,050 --> 00:54:18,470
+heart diseases، Duodenal atresia، يعني اختلالات
+
+541
+00:54:18,470 --> 00:54:26,870
+القلب، التركيبية، أو المشاكل للقلب، تسكير الأبهر،
+
+542
+00:54:26,870 --> 00:54:33,610
+احتمالية أكبر للسرطانات، احتمالية أكبر للتخلف
+
+543
+00:54:33,610 --> 00:54:41,850
+العقلي. الآن باستراحة، يعني ميزة اللي عندهم Down
+
+544
+00:54:41,850 --> 00:54:48,810
+Syndrome، حقيقةً، يعني تذكروا دائماً عنهم إنهم عندهم
+
+545
+00:54:48,810 --> 00:54:55,230
+pleasant personality، يعني شخصيتهم لطيفة، حبابين،
+
+546
+00:54:55,230 --> 00:55:02,910
+بنحبهم، حلوين، تعاملهم يعني حلو. يعني، والـLife
+
+547
+00:55:02,910 --> 00:55:10,750
+expectancy 55-60. يعني هذه باعتبرها أنا دائماً إنه الواحد
+
+548
+00:55:10,750 --> 00:55:17,290
+يتذكر مثل هذه الحالة، هي موجودة ومتواجدة، أو تقريباً
+
+549
+00:55:17,290 --> 00:55:25,670
+واحدة في 850 ألف حالة، يعني تقريباً أقل من واحد في
+
+550
+00:55:25,670 --> 00:55:30,650
+الألف، أكثر شوية من واحد في الألف، واحد في 850 بتوقع
+
+551
+00:55:30,650 --> 00:55:36,070
+يكون عنده Down Syndrome، فيعني
+
+552
+00:55:36,070 --> 00:55:41,210
+هؤلاء جزء من المجتمع، بدّي إياكم واحد يحن عليهم و .. بس
+
+553
+00:55:41,210 --> 00:55:44,750
+أنا بظن، يعني من أجمل الأشياء إنهم لطيفين، يعني
+
+554
+00:55:44,750 --> 00:55:49,350
+آه، في أسئلة؟
+
+555
+00:55:49,350 --> 00:55:57,530
+فإذا في حد عنده سؤال، يسأل. الملاحظة المهمة أو مهمة
+
+556
+00:55:57,530 --> 00:56:04,330
+كثير، فضلاً عن أن الـ Down Syndrome أحياناً كثيرة
+
+557
+00:56:04,330 --> 00:56:05,910
+مرتبطة بعمر الأم
+
+558
+00:56:08,570 --> 00:56:14,390
+إذا بالذات الأم عمرها أكثر من الأربعين سنة، نسبة
+
+559
+00:56:14,390 --> 00:56:19,850
+حدوث الـDown Syndrome ترتفع بنسبة عالية جداً
+
+560
+00:56:19,850 --> 00:56:24,810
+يعني هنا الطريقتين
+
+561
+00:56:24,810 --> 00:56:30,350
+للدراسة، في بزل السلى، أو اللي هو أخذ سائل
+
+562
+00:56:30,350 --> 00:56:35,030
+حوالي من الجنين، أو الانتظار، يعني هذه
+
+563
+00:56:35,030 --> 00:56:39,630
+طريقة من الدراسات. للأسف في دول ثانية، بيعتبرونه إنه
+
+564
+00:56:39,630 --> 00:56:47,510
+فحص للـ DNA، أو لقي مرض معين في ذات الحمل، إنه
+
+565
+00:56:47,510 --> 00:56:54,270
+بيعرضوا الإجهاض، حتى ما يطلع الطفل عنده إصابة، أساساً
+
+566
+00:56:54,270 --> 00:56:57,730
+باعتباره إنه فيه جوانب أخلاقية في الطب
+
+567
+00:56:57,730 --> 00:57:04,030
+وأخلاقية في التعامل مع الحياة وكذا، لأن إحنا
+
+568
+00:57:04,030 --> 00:57:08,390
+تقريباً، يعني في كلام إنه قبل نفخ الروح، يعني ذاك
+
+569
+00:57:08,390 --> 00:57:13,390
+الروح، اللي هو تقريباً 120 يوم، يعني فيه شوية خلاف
+
+570
+00:57:13,390 --> 00:57:17,650
+بين الفقهاء والعلماء، ممكن الواحد يعرض الإجهاض
+
+571
+00:57:17,650 --> 00:57:24,390
+وممكن، يعني بما إنه لسه مش كائن
+
+572
+00:57:24,390 --> 00:57:29,990
+أو مش إنسان مكتمل، يعني، فالفكرة يعني، بس النقطة
+
+573
+00:57:29,990 --> 00:57:37,000
+الأساسية، إنه إذا كبر عمر الأم، نسبة الـ Down
+
+574
+00:57:37,000 --> 00:57:42,600
+Syndrome بتكبر كثير، ماشي؟ وخصوصاً فوق سن الأربعين
+
+575
+00:57:42,600 --> 00:57:49,520
+يعني، هو  النسبة بتكون كبيرة،  كبيرة جداً، فهذه ناحية، ناحية
+
+576
+00:57:49,520 --> 00:57:55,780
+ثانية، يعني من الأشياء اللي الواحد بده ينتبه لها، أن
+
+577
+00:57:55,780 --> 00:58:00,920
+أحياناً الـ Trisomy 21 ما بيكونش في كل الخلايا،
+
+578
+00:58:00,920 --> 00:58:05,460
+بتكون في نسبة من الخلايا، والمقصود إنه الـ Non
+
+579
+00:58:05,460 --> 00:58:12,180
+-disjunction هذا اللي صار، يعني مش على مستوى الـ
+
+580
+00:58:12,180 --> 00:58:16,860
+Egg والـ Sperm، بحيث إنه واحد منهم بيكون فيه
+
+581
+00:58:16,860 --> 00:58:21,120
+المشكلة. لو بالـ Egg والـ Sperm الأصليين، كل
+
+582
+00:58:21,120 --> 00:58:24,720
+الخلايا اللي راح تطلع راح تكون فيها مشاكل، بس لو
+
+583
+00:58:24,720 --> 00:58:28,660
+صار Non-disjunction بعدين، يعني بعد ما صارت
+
+584
+00:58:28,660 --> 00:58:34,500
+Fertilized Egg وانقسمت مثلاً مرتين، ثلاث، فصار عندي
+
+585
+00:58:34,500 --> 00:58:39,140
+مثلاً 16 خلية، واحدة منهم هي اللي صار فيها Non
+
+586
+00:58:39,140 --> 00:58:44,000
+-disjunction، في حتة إنه صارت فيها Trisomy 21، في
+
+587
+00:58:44,000 --> 00:58:48,460
+واحدة منهم. في حتة إنه بنتج عن هذا الأمر إنه راح
+
+588
+00:58:48,460 --> 00:58:55,120
+يكون إنه نسبة، يعني ربع الخلايا، ثلث الخلايا، 60% من
+
+589
+00:58:55,120 --> 00:58:59,960
+الخلايا اللي فيها الخلل، والبقية طبيعية. في تفاوت،
+
+590
+00:58:59,960 --> 00:59:09,760
+يعني في درجات. فهي طبيعة مهمة هنا، الـ Rough Spots،
+
+591
+00:59:09,760 --> 00:59:13,600
+الـ Brush Field Spots، هنا حاطين كيف شكل العين، يعني
+
+592
+00:59:13,600 --> 00:59:17,840
+شكل معين، وهي الـ Epicanthic Fold اللي هي للجوا
+
+593
+00:59:17,840 --> 00:59:25,200
+و Big Tongue، و Pleasant Personality. ويعني هذه اللي
+
+594
+00:59:25,200 --> 00:59:31,370
+هو Down Syndrome، من أشياء الأمراض الكروموزومية اللي
+
+595
+00:59:31,370 --> 00:59:37,430
+هي في المجتمع، الـ
+
+596
+00:59:37,430 --> 00:59:48,290
+فيه هناك، يعني أحياناً حتى لو أنا مش كعدد، كـ band،
+
+597
+00:59:48,290 --> 00:59:51,810
+وعدد، ممكن ألاقي في
+
+598
+00:59:56,860 --> 01:00:04,460
+يعني أحياناً مظهرياً بكون إنسان شكله، لما نعمله
+
+599
+01:00:04,460 --> 01:00:09,540
+Carrier-type، لما أدققش كثير، ولكن بالأول إنه بس في
+
+600
+01:00:09,540 --> 01:00:17,120
+نسختين من الـChromosome 21. فبظن إن التشخيص غلط، أو
+
+601
+01:00:17,120 --> 01:00:24,080
+بقول إنه فيه مشكلة، بكون إنه الـChromosome 21 كما
+
+602
+01:00:24,080 --> 01:00:30,060
+هو في الصورة هذه، راكب نسخة منه على كروموزوم 14، كبير
+
+603
+01:00:30,060 --> 01:00:37,820
+كروموزوم 14. وبالتالي، أحياناً الـ… الـ… يعني هنا
+
+604
+01:00:37,820 --> 01:00:41,940
+إحنا حاطين مثال إنه أنا المفروض بشكل طبيعي أكون
+
+605
+01:00:41,940 --> 01:00:48,480
+عند كروموزوم 14 وكروموزوم 21 منفصلات بهذا الشكل.
+
+606
+01:00:48,480 --> 01:00:55,160
+إذا في عندي Balanced Translocation بهذا الشكل، إنه
+
+607
+01:00:55,460 --> 01:00:59,060
+الـ Chromosome 21 اللي هو أنه أصغر واحد، ومطرد هيك،
+
+608
+01:00:59,060 --> 01:01:03,800
+وصغير،  لصق كله بالغلط مع Chromosome 14، وظلوا
+
+609
+01:01:03,800 --> 01:01:10,120
+موجودين هناك. فإذا إنسان خلاياه بهذا الشكل، برضه هذا
+
+610
+01:01:10,120 --> 01:01:15,700
+ما عنده مشكلة، إذا كانت بشكل مختلف بهذه الأشياء
+
+611
+01:01:15,700 --> 01:01:20,360
+بتكون الأمور Unbalanced، وبتروح تكون فيها مشاكل
+
+612
+01:01:20,360 --> 01:01:27,290
+مختلفة كبيرة. هنا راح يكون Down، لأنه فيه زيادة طبعاً
+
+613
+01:01:27,290 --> 01:01:31,310
+هاي one copy، وفيه copies ثانية زيها، فبنتج عن هذا
+
+614
+01:01:31,310 --> 01:01:35,210
+الأمر الثاني، اللي نفترضه راح تكون طبيعية، راح يكون
+
+615
+01:01:35,210 --> 01:01:40,570
+أنه عندي ثلاثة، أو هنا فيه فقد تام للـ 21، هنا في
+
+616
+01:01:40,570 --> 01
+
+667
+01:07:01,820 --> 01:07:05,620
+fourth pharyngeal pouches أتأمل أنكم أخذتم الـ
+
+668
+01:07:05,620 --> 01:07:10,820
+embryology نتيجة هذا الخلل بيصير عندي ثلاث مظاهر
+
+669
+01:07:10,820 --> 01:07:15,820
+رئيسية الـ third والـ fourth pharyngeal pouches
+
+670
+01:07:15,820 --> 01:07:23,000
+بيكون فيهم لأنهم راح يعطي الـ Thymus أو الغدة الـ
+
+671
+01:07:23,000 --> 01:07:29,900
+T اللي هي تبعت المناعة اللي في الصدر، المنطقة
+
+672
+01:07:29,900 --> 01:07:34,640
+الأمامية من الصدر، فبيصير عندي Absent Thymus والـ
+
+673
+01:07:34,640 --> 01:07:38,020
+Thymus ضرورية لـ Development لـ T-cells في
+
+674
+01:07:38,020 --> 01:07:44,280
+المناعة، هي بتتعلم، هي تتكون، هي تتنشط في الـ Thymus
+
+675
+01:07:44,280 --> 01:07:47,880
+فبيصير عندي Absence of T-cells وبالتالي عندي Immune
+
+676
+01:07:47,880 --> 01:07:52,100
+Deficiency، بيصير عنده Immune Deficiency، الوظيفة
+
+677
+01:07:52,100 --> 01:07:55,480
+الثانية للـ third والـ fourth pharyngeal pouches إن
+
+678
+01:07:55,480 --> 01:07:59,780
+هي بتشترك في الـ root of the heart، في الـ major
+
+679
+01:07:59,780 --> 01:08:04,100
+blood vessels، فالـ major blood vessels، الأورطة
+
+680
+01:08:04,100 --> 01:08:08,460
+والبلمونري آرتي والـ truncus arteriosus والأشياء
+
+681
+01:08:08,460 --> 01:08:12,920
+هذه بتصير فيها خلل، فبيصير عندي congenital heart
+
+682
+01:08:12,920 --> 01:08:18,160
+disease، بيصير عندي مرض قلب خلقي، عيب خلقي في القلب
+
+683
+01:08:18,920 --> 01:08:22,020
+الشغل الثالث اللي بتكون نتيجة الـ third والـ
+
+684
+01:08:22,020 --> 01:08:28,480
+fourth pharyngeal pouches اللي هم الـ الـ الـ الـ
+
+685
+01:08:28,480 --> 01:08:33,540
+Parathyroid glands، والـ Parathyroid glands أهميتهم
+
+686
+01:08:33,540 --> 01:08:37,200
+بالتحكم في الـ metabolism تبع الـ calcium، فبيصير
+
+687
+01:08:37,200 --> 01:08:42,220
+عندي مشكلة hypocalcemia و tetany، بصير الجنين أو
+
+688
+01:08:42,220 --> 01:08:46,920
+الـ أو الجنين يعني الـ newborn بصير عنده تشنجات
+
+689
+01:08:46,920 --> 01:08:51,020
+و tetany ويكون نتيجة الـ Hypocalcemia بسبب
+
+690
+01:08:51,020 --> 01:08:57,780
+الـ Hypoparathyroidism، فالـ Velo-cardio-facial syndrome، أي الاسم الثاني
+
+691
+01:08:57,780 --> 01:09:01,880
+للـ DiGeorge Syndrome، يكون عندي مشاكل في القلب، مشاكل
+
+692
+01:09:01,880 --> 01:09:06,680
+في الـ Thymus وفي المناعة، ومشاكل في الـ Calcium وفي
+
+693
+01:09:06,680 --> 01:09:11,160
+الـ Metabolism تبع الـ Hypoparathyroidism
+
+694
+01:09:17,070 --> 01:09:22,250
+النقطة الأخيرة فيهم اللي هي قضية إنه راح يكون
+
+695
+01:09:22,250 --> 01:09:28,630
+بيسموها dysmorphic features، الحاطين هنا أظن صور
+
+696
+01:09:28,630 --> 01:09:32,250
+اللي
+
+697
+01:09:32,250 --> 01:09:38,210
+هم الـ Trisomy 21، خلّيني أشوف، لأ مش حاطين
+
+698
+01:09:38,210 --> 01:09:41,870
+DiGeorge Syndrome، بيبينوا، بيكون بيسموها loss of
+
+699
+01:09:41,870 --> 01:09:50,300
+ears، يعني الـ… الـ… لما الواحد يشوف الجنين الأصل
+
+700
+01:09:50,300 --> 01:09:54,180
+في الإنسان، إذا الواحد انتبه على حاله إنه الأذنين
+
+701
+01:09:54,180 --> 01:09:57,820
+بيكونوا على مستوى العين، يعني إذا أخدت خط بين
+
+702
+01:09:57,820 --> 01:10:02,380
+الآذنين تقريباً هنا، إذا الأذنين الواحد أنزل
+
+703
+01:10:02,380 --> 01:10:07,080
+من هذا الوضع بيسموها loss of ear، بيكون increased
+
+704
+01:10:07,080 --> 01:10:11,340
+philtrum اللي هي المسافة بين الأنف والشفة العليا
+
+705
+01:10:11,880 --> 01:10:16,560
+اللي كونها شكلها increase، فإنها شكل مميز، يعني
+
+706
+01:10:16,560 --> 01:10:24,000
+فهذا إيش اسمه DiGeorge Syndrome، فبقية الـ
+
+707
+01:10:24,000 --> 01:10:29,920
+diseases، بدّي، يعني الفكرة فيها أمراض كثيرة وهي
+
+708
+01:10:29,920 --> 01:10:36,100
+list of examples، يعني هذولة نسبة أو يعني عدد
+
+709
+01:10:36,100 --> 01:10:42,400
+محدود من الأمثلة، وإنه في عندي أمراض كثيرة أخرى
+
+710
+01:10:42,400 --> 01:10:48,580
+بيكون، أنا المشكلة عندي هي segmental deletion أو
+
+711
+01:10:48,580 --> 01:10:53,560
+duplication، يعني عبارة عن قطعة مش الـ…
+
+712
+01:10:53,560 --> 01:11:00,120
+الـ chromosome كامل، ماشي؟ فهذه أشياء بتحدث وموجودة
+
+713
+01:11:00,120 --> 01:11:08,040
+في الطبيعة، موجودة في الحياة، موجودة ومؤثرة، والواحد
+
+714
+01:11:08,040 --> 01:11:15,160
+يطلع عنده حالة بده يحسن التنقيب والبحث عن من
+
+715
+01:11:15,160 --> 01:11:21,760
+المراجع العلمية المعتمدة، الـ Online Databases زي
+
+716
+01:11:21,760 --> 01:11:27,190
+ما بقوله، قواعد البيانات على الـ Net، بحيث إنه يدخل
+
+717
+01:11:27,190 --> 01:11:31,630
+كل المعلومات اللي بعرفها كمظاهر ويحاول يلاقي منها
+
+718
+01:11:31,630 --> 01:11:39,170
+شو التشخيص أو وين العلة عشان يختار بعدين الـ Test
+
+719
+01:11:39,170 --> 01:11:42,370
+المناسب حتى يثبت إن هذا الموضوع موجود
+
+720
+01:11:42,370 --> 01:11:46,910
+فالـ Rearrangement
+
+721
+01:11:46,910 --> 01:11:52,770
+لقضية اللي يصير Deletion أو Duplication، اثنانهم
+
+722
+01:11:52,770 --> 01:11:58,920
+لنفس الـ Mechanism، لما نكون عندي سواء إذا كامل، Non-
+
+723
+01:11:58,920 --> 01:12:02,920
+distinction، يعني بتكون اثنان مع بعض بيروحوا هيك
+
+724
+01:12:02,920 --> 01:12:07,720
+أو صفر بيروح الجهة الثانية، بتكون كاملة بس أحياناً
+
+725
+01:12:07,720 --> 01:12:13,160
+بتكون على قطعة وبتكون إنه شيء بينتقل من محل لمحل
+
+726
+01:12:13,160 --> 01:12:18,220
+ثاني، فبنتج عنه إنه في نسخة راح تكون Duplication
+
+727
+01:12:18,220 --> 01:12:23,440
+وفي نسخة ثانية أو جهة ثانية راح يكون فيه Deletion
+
+728
+01:12:23,440 --> 01:12:32,240
+فهي لنفس الـ Mechanism، هنا برضه يعني هاي هون اللي
+
+729
+01:12:32,240 --> 01:12:37,460
+عملنا عن طريق الـ Karyotype، على Binding، دورت على
+
+730
+01:12:37,460 --> 01:12:45,080
+شيء معين، ممكن أنا هنا الـ FISH كأسلوب أدور على
+
+731
+01:12:45,730 --> 01:12:53,610
+بطريقة معينة عليهم، وبعدين في عندي اللي هو micro-
+
+732
+01:12:53,610 --> 01:12:59,850
+arrays، بتكون أنا ممكن أدور بطريقة معينة، وبعدين
+
+733
+01:12:59,850 --> 01:13:10,590
+بروح أقراها ويعني بتكون عندي، شو اسمه؟ محاضرة، أنا،
+
+734
+01:13:10,590 --> 01:13:11,610
+محاضرة، محاضرة
+
+735
+01:13:14,980 --> 01:13:23,480
+فأسف، يعني هذه الآليات المختلفة لمعرفة النوع
+
+736
+01:13:23,480 --> 01:13:30,080
+الثاني من الـ Chromosome Anomalies، يعني هنا
+
+737
+01:13:30,080 --> 01:13:36,060
+كـ Chromosome كامل، فيه عدد محدود، قطع من
+
+738
+01:13:36,060 --> 01:13:41,140
+الكروموزومات، فيه برضه نسبة موجودة، هناك انفلونزا عليها
+
+739
+01:13:41,140 --> 01:13:46,880
+دخلنا على قصة الـ DiGeorge Syndrome كمثال، ما بديش غيره،
+
+740
+01:13:46,880 --> 01:13:56,600
+بس الفكرة إنه بيكون في عندي يعني مظاهر متعددة وأنا
+
+741
+01:13:56,600 --> 01:14:00,060
+بإمكاني أدرسها بطرق مختلفة
+
+742
+01:14:03,080 --> 01:14:07,620
+في حاجة اسمها "Brother Willy Engelman Syndromes"
+
+743
+01:14:07,620 --> 01:14:12,700
+كانوا حاطين صورهم بهذا الشكل، ماشي، رخاوة في
+
+744
+01:14:12,700 --> 01:14:20,420
+العضلات، تخلف عقلي، أمراض، مشاكل ثانية، إذا الواحد
+
+745
+01:14:20,420 --> 01:14:27,520
+بدّه ياخد خط الطب كـ Pediatrician، كـ Geneticist أو
+
+746
+01:14:27,520 --> 01:14:30,340
+كذا، بدّه يصير يعرف عنهم ويتعامل معهم
+
+747
+01:14:34,340 --> 01:14:38,860
+الآن الجانب الأخير من الأمراض الكروموزومية اللي هو
+
+748
+01:14:38,860 --> 01:14:43,220
+الـ Sex Chromosomes، الـ Sex Chromosomes يعني ناحية
+
+749
+01:14:43,220 --> 01:14:52,960
+مهمة كتير ويعني بدها تكون نابعة للواحد من فهم ضروري
+
+750
+01:14:52,960 --> 01:15:02,380
+للمبادئ تبعها بالنسبة للـ Sex Development وتطور
+
+751
+01:15:02,380 --> 01:15:12,050
+الإنسان الجنسي، بنلاقي أنا عندي، بتكلم عن ثلاث
+
+752
+01:15:12,050 --> 01:15:20,710
+مستويات من المظاهر، وأحياناً طبعاً في الغالب بتكون
+
+753
+01:15:20,710 --> 01:15:27,830
+بطرق معينة، بس هناك طرق متعددة للاختلالات، فالأصل
+
+754
+01:15:27,830 --> 01:15:33,850
+الإنسان الرجل، الذكر بيكون عنده X Y chromosome
+
+755
+01:15:35,940 --> 01:15:44,340
+التركيب للـ genes أو الأعضاء التناسلية تبعته إنه
+
+756
+01:15:44,340 --> 01:15:51,480
+عنده خصي أو Testes، ماشي، وبالأخير بتعطي مظاهر
+
+757
+01:15:51,480 --> 01:15:59,640
+اللي بنرجعها للدكورة، يعني الصوت أجش، الشعر في
+
+758
+01:15:59,640 --> 01:16:04,500
+اللحية، وفي مناطق معينة في الجسم، كمية العضلات في
+
+759
+01:16:04,500 --> 01:16:10,920
+جسمه أكبر، الهرمونات في جسمه تكون مختلفة، هذه
+
+760
+01:16:10,920 --> 01:16:15,040
+اللي بيسموها مظاهر الدكورة أو الأنوثة، الـ
+
+761
+01:16:15,040 --> 01:16:23,940
+Phenotype، الـ Phenotype هذا هو نتيجة أول شيء، جزء
+
+762
+01:16:23,940 --> 01:16:28,840
+منه الكروموزومات، وما ينتج عنها من بروتينات، وما
+
+763
+01:16:28,840 --> 01:16:35,520
+ينتج عنها من تراكيب، ثم بعد ذلك جوانب هرمونية
+
+764
+01:16:35,520 --> 01:16:41,980
+نتيجة الـ Gonads، وبعد ذلك الصراحة الجوانب
+
+765
+01:16:41,980 --> 01:16:49,870
+المجتمعية، يعني الـ role-playing، يعني المجتمع عادة
+
+766
+01:16:49,870 --> 01:16:56,750
+الطفل من صغره إذا كان ذكر بيصيروا يقولوا أنت زلمة
+
+767
+01:16:56,750 --> 01:17:01,570
+واش بتعيط زي البنات؟ ولا بيصيروا يربّوه على إنه يكون
+
+768
+01:17:01,570 --> 01:17:06,190
+خشين، إنه ما يشكيش وإنه كده وإنه كده، كدا بتلاقي مظاهر
+
+769
+01:17:06,190 --> 01:17:11,390
+حتى من ناحية المجتمع بتتدخل شوية، يعني مناسب
+
+770
+01:17:11,900 --> 01:17:17,960
+لأنه هذا رجل أو هي أنثى، فبالمقابل
+
+771
+01:17:17,960 --> 01:17:23,060
+الـ Females، في عندنا بيكون عندهم XX chromosomes
+
+772
+01:17:23,060 --> 01:17:30,740
+بتكون عندنا مبايض، Ovaries، وبعدين بيصير الشكل
+
+773
+01:17:30,740 --> 01:17:36,120
+ال مميز للـ Phenotype كـ Female، تتدخل فيه أشياء
+
+774
+01:17:36,120 --> 01:17:40,060
+كثيرة الآن
+
+775
+01:17:40,470 --> 01:17:46,230
+الـ Y-Chromosome، حقيقةً فيه عدد قليل من الجينات
+
+776
+01:17:46,230 --> 01:17:51,890
+حاطين هنا تفاصيل، من أصغر الـ Chromosomes كمان زي
+
+777
+01:17:51,890 --> 01:17:57,070
+الـ Chromosome 21 قريب منه يعني في الحجم، وبكون
+
+778
+01:17:57,070 --> 01:18:06,910
+ما فيه، إيش اسمه؟ ما يكونش فيه يعني كبير عدد من
+
+779
+01:18:06,910 --> 01:18:12,010
+الـ genes اللي بتأثر على أشياء محددة، يعني،
+
+780
+01:18:12,010 --> 01:18:16,450
+ماشي، في أسئلة؟
+
+781
+01:18:16,450 --> 01:18:19,650
+السلام
+
+782
+01:18:19,650 --> 01:18:23,250
+عليكم، في أسئلة؟ تمام لحد الآن يا دكتور، تمام، ما في
+
+783
+01:18:23,250 --> 01:18:30,010
+سؤال يعني، طيب، الفهم لكيف تطور الذكور والإناث
+
+784
+01:18:30,590 --> 01:18:34,370
+وكيف ربنا حطّ فينا هيك الأشياء، وكيف ربنا خلقنا
+
+785
+01:18:34,370 --> 01:18:46,890
+صراحة فيه يعني أفضل تقدير ويعني كيف الإنسان بيتخلق
+
+786
+01:18:46,890 --> 01:18:51,970
+حقيقةً يعني عجيبة من الله سبحانه وتعالى، من الأشياء
+
+787
+01:18:51,970 --> 01:18:59,560
+اللي لازم تكونوا تتذكروها أولاً إنه في الـ
+
+788
+01:18:59,560 --> 01:19:05,580
+Embryogenesis، يعني في مرحلة تكوين الإنسان، في مرحلة
+
+789
+01:19:05,580 --> 01:19:12,160
+الجنينية المبكرة، ناشئ الإنسان بيولد بالأول أو
+
+790
+01:19:12,160 --> 01:19:21,360
+بيتخلق بالأول وعنده تراكيب يعني ذكورة وأنوثة في
+
+791
+01:19:21,360 --> 01:19:28,560
+نفس الوقت، ناشئ، بقرا "mesonephric duct"، "mesonephric
+
+792
+01:19:28,560 --> 01:19:32,900
+duct"، "mesonephric
+
+793
+01:19:32,900 --> 01:19:38,400
+duct"، "mesonephric duct"، "mesonephric duct"، "mesonephric
+
+794
+01:19:38,400 --> 01:19:39,040
+duct"، "mesonephric duct"، "mesonephric duct"، "mesonephric
+
+795
+01:19:39,040 --> 01:19:39,520
+duct"، "mesonephric duct"، "mesonephric duct"، "mesonephric
+
+796
+01:19:39,520 --> 01:19:42,060
+duct"، "mesonephric duct"، "mesonephric duct"، "mesonephric
+
+797
+01:19:42,060 --> 01:19:50,260
+duct"، "mesonephric duct"، "mesonephric duct"، "mesonephric
+
+798
+01:19:50,260 --> 01:19:59,200
+duct"، "meso يعني بيقولوا الـ Default، يعني الإعداد
+
+799
+01:19:59,200 --> 01:20:06,700
+التلقائي، الـ Default Development بتكون إنه الإنسان
+
+800
+01:20:06,700 --> 01:20:16,420
+بتحول إلى أنثى، إذا فيه الـ Y-Chromosome، ماشي، بتحول
+
+801
+01:20:16,420 --> 01:20:23,340
+للدفع، أما إذا ما فيش Y-Chromosome، يعني وجود الـ X أو
+
+802
+01:20:23,340 --> 01:20:28,620
+أكثر من X أو عدد كبير من الـ X ما بيخلي الأنثى
+
+803
+01:20:28,620 --> 01:20:35,100
+تتكون، عدم وجود الـ Y-Chromosome هو ما يدفع الـ
+
+804
+01:20:35,100 --> 01:20:41,560
+Development إلى قضية أن يكون الشخص هذا أنثى، فوجود
+
+805
+01:20:41,560 --> 01:20:46,220
+الـ Y-Chromosome هو اللي بيصنع الـ Testes، بيحول
+
+806
+01:20:46,220 --> 01:20:52,050
+إلى Testes وبيغير شكل القنوات البولية والقنوات
+
+807
+01:20:52,050 --> 01:20:58,390
+التناسلية بحيث إنه يعطي شكل الذكر في الـ Internal
+
+808
+01:20:58,390 --> 01:21:02,490
+والـ External Genitalia، اللي هم الأعضاء التناسلية
+
+809
+01:21:02,490 --> 01:21:09,750
+الداخلية والخارجية، البربخ والقنوات
+
+810
+01:21:09,750 --> 01:21:17,170
+تبعات الـ Sperms والبروستاتا
+
+811
+01:21:17,170 --> 01:21:25,120
+والذكر والأشياء هذه، في مقابل عدم وجود الـ Y
+
+812
+01:21:25,120 --> 01:21:28,740
+Chromosome هو ما يدفع الـ Development إنه تتحول
+
+813
+01:21:28,740 --> 01:21:33,280
+باتجاه الأنثى، وهي اللي بيسموها الـ Default، يعني
+
+814
+01:21:33,280 --> 01:21:37,300
+هنا إذا ما فيش أي مؤثر خارجي راح تمشي بهذا الطريق
+
+815
+01:21:37,300 --> 01:21:44,440
+فبتكون المبيض، وبعدين قنوات Fallopian وبعدين بقية
+
+816
+01:21:44,440 --> 01:21:50,190
+الرحم وقطع وبعدين المهبل وغيره، الـ Female Internal
+
+817
+01:21:50,190 --> 01:21:56,510
+و External Genitalia، ماشي، فالإنسان
+
+818
+01:21:56,510 --> 01:22:06,270
+الطبيعي يعني عادةً إذا ذكر XY، إذا أنثى XX، والأصل
+
+819
+01:22:06,270 --> 01:22:12,630
+يعني في التحكم إنه تروح باتجاه الذكر، الذكورة هي
+
+820
+01:22:12,630 --> 01:22:19,880
+وجود الـ Y، كثير من المظاهر مرتبطة بعد ما تتكون الـ
+
+821
+01:22:19,880 --> 01:22:24,280
+Testes وتكون مصدر للهرمونات، الـ Testosterone
+
+822
+01:22:24,280 --> 01:22:32,480
+وهو بيؤدي إلى إن المظاهر تتابع وتتغير وتكون بالشكل
+
+823
+01:22:32,480 --> 01:22:41,100
+اللي عندنا موجود، فهي نواحي مهمة، الآن في ظاهرة
+
+824
+01:22:41,100 --> 01:22:47,490
+حكينا عنها من قبل، طبعاً الـ X-Chromosome أكبر بكثير
+
+825
+01:22:47,490 --> 01:22:52,690
+يعني الـ Chromosome محرز، كبير وفي عليه جينات
+
+826
+01:22:52,690 --> 01:22:57,790
+كثيرة وله دخل في أشياء كثيرة، طبعاً أهم ميزة فيه
+
+827
+01:22:57,790 --> 01:23:02,670
+أو أهم مشكلة فيه إنه لما يكون عندي نسخة
+
+828
+01:23:02,670 --> 01:23:08,730
+مريضة، الـ Male راح يكون يأكل هوا، لأنه لو نسخة
+
+829
+01:23:08,730 --> 01:23:13,390
+واحدة ما فيش عنده مجال، إذا بالذات Recessive، وهو يعني
+
+830
+01:23:13,390 --> 01:23:18,830
+صفة متنحية راح تكون إنها رغم إنها متنحية بس بتظهر
+
+831
+01:23:18,830 --> 01:23:25,990
+بالذكور، فدايماً يعني قضية الـ X-Chromosomes وأهميته
+
+832
+01:23:25,990 --> 01:23:32,510
+يعني شغل سبحان الله مهم كتير، فلمّا
+
+833
+01:23:32,510 --> 01:23:39,330
+يكون الأنثى أو حتى لو ذكر مثلاً XXY، والـ XXY راح
+
+834
+01:23:39,330 --> 01:23:47,430
+يكون مظهرياً إيش؟ ذكر، لأنه عند الـ Y، لما يكون XXY
+
+835
+01:23:47,430 --> 01:23:51,470
+الـ two X دول بيكونوا الشغالات، اثنان في كل
+
+836
+01:23:51,470 --> 01:24:02,490
+الخلايا، لو أنا بقدر أدرس بشكل عميق أنواع الـ DNA
+
+837
+01:24:02,490 --> 01:24:08,510
+الشغال في كل خلية بلاقي إنه في حالة لما يكون عندي
+
+838
+01:24:08,510 --> 01:24:14,650
+أكثر من نسخة من الـ X، واحد منهم بس اللي شغالة، فهنا
+
+839
+01:24:14
+
+889
+01:28:53,690 --> 01:29:02,090
+«كروموزومات» 49 وعندها X X X X X ناشي، تحدث، غادرة
+
+890
+01:29:02,090 --> 01:29:07,530
+جداً وإذا بدي أدور عليها يمكن ألاقيها وكذا بس يعني
+
+891
+01:29:07,530 --> 01:29:12,210
+الفكرة، انتبهوا هنا إنه دائماً سواء Male ولا
+
+892
+01:29:12,210 --> 01:29:16,870
+Female فيه one copy of the X chromosome which is
+
+893
+01:29:16,870 --> 01:29:24,930
+activeاللي بيخلّي الإنسان مذكر هو الـ Y بغض النظر
+
+894
+01:29:24,930 --> 01:29:28,530
+يعني هو أنا حاطط نسخة أو نسختين أول مرة بشوف هيك
+
+895
+01:29:28,530 --> 01:29:37,710
+هي الـ XY-Chromosome أو XYY نفس الشيء أو XXY XXYY
+
+896
+01:29:37,710 --> 01:29:45,210
+يعني الدواهر الـ Non-disjunction دواهر عدم
+
+897
+01:29:45,210 --> 01:29:51,540
+الانفصال بين الـ X والـ Y-Chromosome في الـ Cell Cycle
+
+898
+01:29:51,540 --> 01:29:58,220
+أكثر من بقية الكروموزومات، السبب إنه واحد كبير
+
+899
+01:29:58,220 --> 01:30:03,300
+وواحد صغير، إنك تركب اثنين واختلاف كبير في الحجم
+
+900
+01:30:03,300 --> 01:30:07,560
+بالبعض، عشان ينفصلوا بشكل سليم، هذا ما بيحدث
+
+901
+01:30:07,560 --> 01:30:15,160
+وبالتالي احتماليات الخلل أكبر، فهذه أمثلة اسمها الـ
+
+902
+01:30:15,160 --> 01:30:21,280
+Bar Body اللي هو الـ Inactive X-Chromosome، وفي عندنا
+
+903
+01:30:21,280 --> 01:30:26,340
+أمثلة على أحياناً بتكون بهذا الشكل، إن شاء الله
+
+904
+01:30:26,340 --> 01:30:34,880
+إنها واضحة، بظنّي صارت الساعة عشرة، بنكمل إن شاء
+
+905
+01:30:34,880 --> 01:30:40,120
+الله، يوم بعد إذنك، يعني قبل ما تنهي، النقطة اللي
+
+906
+01:30:40,120 --> 01:30:43,520
+سأل عنها كريم بخصوص الـVariation في الـIndividual
+
+907
+01:30:43,520 --> 01:30:48,720
+Genomes، يعني في .. مش عارف إيه، أظنّ أنّه موجود يا
+
+908
+01:30:48,720 --> 01:30:55,680
+كريم في Chapter رقم 4، صحيح؟ إذا بتسمعني يا كريم
+
+909
+01:30:55,680 --> 01:31:01,160
+Chapter رقم 4؟ آه، صحيح، موجود في Chapter رقم 4
+
+910
+01:31:01,160 --> 01:31:05,860
+آه، شو بدّك؟ النقطة الـ Variation في الـ
+
+911
+01:31:05,860 --> 01:31:10,140
+Individual Genomes يعني
+
+912
+01:31:10,140 --> 01:31:14,340
+إحنا كل المحاضرة عن إنه فيه Variation في الـ
+
+913
+01:31:14,340 --> 01:31:20,740
+Genome، الـ Genome شو هو؟ الـ Genome هو مجمل المادة
+
+914
+01:31:20,740 --> 01:31:26,100
+الوراثية كلها، لما نتكلم Genome يعني كل الـ DNA تبع
+
+915
+01:31:26,100 --> 01:31:32,880
+الكائن الإنساني هذا، أو الإنسان هذا، ففي عندي يعني
+
+916
+01:31:33,500 --> 01:31:39,160
+فأي نوع الـ Variation؟ هو له أنواع كثيرة، لما يكون
+
+917
+01:31:39,160 --> 01:31:44,700
+يشوف اللي بحكي عنه يفرجيني، يعني دكتور يعني خلّيني
+
+918
+01:31:44,700 --> 01:31:54,360
+أشاركك الصورة اللي هو بعتلي إياها، نعم، آه طيب،
+
+919
+01:31:54,360 --> 01:32:01,840
+أه، فرجيني الصورة
+
+920
+01:32:01,840 --> 01:32:07,200
+موجودة الآن، هي، نعم، إذا أنت شايفها؟ طيب، هسا هاي
+
+921
+01:32:07,200 --> 01:32:12,960
+نحكي عن حالة محددة، اللي هي نوع من الـ Hemophilia
+
+922
+01:32:12,960 --> 01:32:20,020
+الـ Hemophilia اللي هو الـ Factor 8 تبع الـ
+
+923
+01:32:20,020 --> 01:32:26,100
+Clotting Factor تبع اللي بيعمل تجلّط الدم، ماشي، موجودة
+
+924
+01:32:26,100 --> 01:32:31,500
+على الـ X-Chromosome، هسا اللي بيصير أحياناً
+
+925
+01:32:31,770 --> 01:32:38,950
+ممكن مثلًا «Snip» أو «As if» «Deletion» «of One
+
+926
+01:32:38,950 --> 01:32:43,510
+Nucleotide» بيعمل «Frame Shift»، بيخرّب لك كل
+
+927
+01:32:43,510 --> 01:32:49,830
+البروتين ويغلط الـ «DNA»، يشغّل، ماشي، هنا ظاهرة
+
+928
+01:32:49,830 --> 01:32:56,970
+ثانية، الظاهرة هذه إنه أنا في عندي قطعتين ممكن
+
+929
+01:32:56,970 --> 01:33:04,040
+هذول يلتبِقان على بعض، فلما اللي هي ما بين النقطة A
+
+930
+01:33:04,040 --> 01:33:12,000
+والنقطة B، فالأصل الـ «أصل» الـ «فاكتور 8»، ماشي له
+
+931
+01:33:12,000 --> 01:33:23,880
+23 exons وبينهم 22 introns، يعني لما أنا قاعد
+
+932
+01:33:23,880 --> 01:33:28,900
+أصنع البروتين هذا، بسوي بالأول transcription
+
+933
+01:33:31,800 --> 01:33:38,700
+للديا الـ RNA لكل الـ Introns والـ Exons، وبعدين
+
+934
+01:33:38,700 --> 01:33:43,140
+بصير أقطع القطع وأركّبهم على بعض، يعطيني البروتين
+
+935
+01:33:43,140 --> 01:33:47,220
+اللي أنا بدّي إياه، واضح؟
+
+936
+01:33:47,220 --> 01:33:52,580
+في الحالة هذه، في بعض حالات الهيموفيليا اللي بيصير
+
+937
+01:33:52,580 --> 01:33:59,920
+أنّ هذول القطعتين لما ييجوا على بعض، احتمال أنّه
+
+938
+01:33:59,920 --> 01:34:08,420
+هيك، يعني يشبك، فلما يشبك وتيجي بعدين أنت تقول بدّي
+
+939
+01:34:08,420 --> 01:34:14,140
+أفكه مرّة ثانية، بيصير الـ Loop، بركب الطريقة معكوسة
+
+940
+01:34:14,140 --> 01:34:22,740
+فاهم عليّ كيف الصورة حاطّينها، فاللي بيصير أنّ الـ AB
+
+941
+01:34:22,740 --> 01:34:28,400
+هذه القطعة اللي سبّبت الإشكالية، راح تخليها تبدأ بدل
+
+942
+01:34:28,400 --> 01:34:34,540
+ما هو رقم 1، اثنين، ثلاثة، لحدّ ثلاثة وعشرين، مظبوط
+
+943
+01:34:34,540 --> 01:34:38,540
+بهذا الشكل، راح يصير إنّه بيبدأ اثنين، وعشرين، وواحد
+
+944
+01:34:38,540 --> 01:34:42,760
+وعشرين وكذا كذا لواحد، وبعدين بيجي ثلاثة وعشرين هنا
+
+945
+01:34:42,760 --> 01:34:48,800
+فراح يخربط لك الدنيا، ويصير البروتين ما له وظيفة ومش
+
+946
+01:34:48,800 --> 01:34:55,300
+كويس، فاهم عليّ؟ فبعض حالات الـ Hemophilia
+
+947
+01:34:55,300 --> 01:35:05,150
+mutation بتكون بهذا الشكل، والسبب أنّه يعني لما تدرس
+
+948
+01:35:05,150 --> 01:35:13,810
+بين الطبيعي وبين المصاب، أول شيء كحجم الـ DNA كامل
+
+949
+01:35:13,810 --> 01:35:19,590
+بتلاقي متساوي، ما فيش هلقلاق، بس ترتيب القطع تبعات
+
+950
+01:35:19,590 --> 01:35:26,610
+الـ Exon اللي هم بدخلوا في صناعة الـ Protein واللي
+
+951
+01:35:26,610 --> 01:35:31,600
+بينهم الـ Introns، هنا صارت الدنيا ملغوصة، مخربطة،
+
+952
+01:35:31,600 --> 01:35:36,520
+لا يمكن الاستفادة من هذه الأشياء، وهذه بعض حالات
+
+953
+01:35:36,520 --> 01:35:48,120
+الـ Hemophilia وبتكون بهذا الشكل، واضح؟ واضح يا كريم؟
+
+954
+01:35:48,120 --> 01:35:55,360
+تمام يا دكتور، فهمت عليك، يعني هذا مثال، أحياناً يعني
+
+955
+01:35:55,360 --> 01:36:00,070
+اللي بدّك تعرفها أنّه الاختلالات الوراثية مش كلها على
+
+956
+01:36:00,070 --> 01:36:05,750
+طبيعة واحدة فقط، يعني إنّ البروتين أو الجين
+
+957
+01:36:05,750 --> 01:36:12,210
+مش موجود تماماً، يعني غير موجود، هذا «deletion»، أي
+
+958
+01:36:12,210 --> 01:36:18,910
+طبيعة، بس هنا صار اللي هي قضية «reverse»، الترتيب
+
+959
+01:36:18,910 --> 01:36:24,430
+القطع، في نفس الجين، إحنا هنا مش جينات مختلفة،
+
+960
+01:36:24,430 --> 01:36:32,740
+فهذا مثال للـ Hemophilia وهو مثال على الـ Genetic
+
+961
+01:36:32,740 --> 01:36:37,980
+Mutation بتخرّب الجين، بتخلّي الإنسان عنده مرض أو
+
+962
+01:36:37,980 --> 01:36:43,060
+Hemophilia وبيبطل يقدر يصنع البروتين هذا، والسبب
+
+963
+01:36:43,060 --> 01:36:49,560
+أنّه اختلفة طريقة صناعة البروتين، بعدين كـ
+
+964
+01:36:49,560 --> 01:36:56,100
+Transcription و Translation، بطلت تقدر تصنعه، تمام؟
+
+965
+01:36:58,550 --> 01:37:01,650
+تمام، إن شاء الله، هو يعني واضحة الصورة أعتقد، عنده
+
+966
+01:37:01,650 --> 01:37:04,890
+في بس سؤال من بسمة، بتسأل يعني الـBalance
+
+967
+01:37:04,890 --> 01:37:08,850
+Translocation، يعني قصدك الـ… قصدك على نفس الـslide
+
+968
+01:37:08,850 --> 01:37:15,130
+شكله؟ هي، هنا بدّك تعتبرها الـ… هنا مش
+
+969
+01:37:15,130 --> 01:37:18,570
+الـTranslocation، يعني الـTranslocation، إحنا عم نحكي
+
+970
+01:37:18,570 --> 01:37:24,850
+عن Band، هنا إحنا بمستوى على one gene، يعني إحنا
+
+971
+01:37:24,850 --> 01:37:32,840
+هنا في مستوى أقل، لما نحكي عن Band وقطع من الـ
+
+972
+01:37:32,840 --> 01:37:41,500
+Chromosomes وقطع أكبر، ماشي، إذا زي ما حطّينا الـ ..
+
+973
+01:37:41,500 --> 01:37:49,620
+إذا خلّيني أورجيگم صورة حطّينا عن Down Syndrome، Down
+
+974
+01:37:49,620 --> 01:37:56,220
+Syndrome، Trisomy 21، واضح، عادة من هناك بس فيه نسبة
+
+975
+01:37:56,220 --> 01:38:04,520
+لما قاعد أدرس الـ الـ الـ الـ 21 Trisomy بلاقي
+
+976
+01:38:04,520 --> 01:38:10,900
+ما فيش 21 Excess، يعني فيه Two copies وبس، فبيكون إنّه
+
+977
+01:38:10,900 --> 01:38:18,780
+فيه نسخة ثالثة راكبة على Chromosome 14، فهسا إذا
+
+978
+01:38:18,780 --> 01:38:24,770
+إنسان عنده نسخة واحدة فقط من الـ Chromosome
+
+979
+01:38:24,770 --> 01:38:29,870
+21 والثانية راكبة على Chromosome 14، فبالأخير أنّه
+
+980
+01:38:29,870 --> 01:38:33,230
+صار Two copies of Chromosome 21 وTwo copies of
+
+981
+01:38:33,230 --> 01:38:39,230
+Chromosome 14، وهذا Balance، هذا هو نفسه إنسان طبيعي
+
+982
+01:38:39,230 --> 01:38:44,350
+لما يكون إنسان يكون Balanced، يعني كمية الـ DNA اللي
+
+983
+01:38:44,350 --> 01:38:50,010
+في جسمه طبيعية، مشابهة لكمية المتوقعة الطبيعية
+
+984
+01:38:50,380 --> 01:38:56,580
+وبالأخير مظهرياً لا يبدو عليه مرض، ولكن، تبيّن الـ
+
+985
+01:38:56,580 --> 01:39:03,220
+DNA لما بدّي يجي هو يخلف، يصير تنقسم خلاياه وتعطي
+
+986
+01:39:03,220 --> 01:39:09,120
+الـ sperm والـ egg والـ ova وكذا، بتلاقي إنّه مستحيل
+
+987
+01:39:09,120 --> 01:39:15,380
+المربطين هذول اثنين مع بعض ينفصلوا بشكل مناسب، فلّا
+
+988
+01:39:15,380 --> 01:39:20,810
+الـ offspring cells، إلا يطلع يا أما زيادة يا أما
+
+989
+01:39:20,810 --> 01:39:25,750
+نقصان، واضح؟ فلما يكون الـ imbalance بتصير الأمراض
+
+990
+01:39:25,750 --> 01:39:34,410
+أكثر، بتكون فيه مشاكل أكثر، هذا المطلوب، تمام
+
+991
+01:39:34,410 --> 01:39:38,710
+إن شاء الله، إذا إن شاء الله نلتقي يوم الأربعاء،
+
+992
+01:39:38,710 --> 01:39:44,710
+بنكمل على الحالات الثانية والأمراض الثانية، الله
+
+993
+01:39:44,710 --> 01:39:49,020
+يعطيكم ما يعطيه، الله عفوك يا دكتور، يعطيك ألف عفو
+
+994
+01:39:49,020 --> 01:39:51,040
+أهلاً وسهلاً، السلام عليكم
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/SNmO_a0evPg_postprocess.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/SNmO_a0evPg_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..b8b1ae22c1e764fd988768f9b2f8e0821d43ef99
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/SNmO_a0evPg_postprocess.srt
@@ -0,0 +1,3976 @@
+1
+00:00:00,000 --> 00:00:05,440
+الـ slide بالضبط أنه اللي قصده بدي يعني أتكلم عنه
+
+2
+00:00:05,440 --> 00:00:14,660
+الفكرة إنه هناك درجة عالية من الاختلافات بين الـ
+
+3
+00:00:14,660 --> 00:00:22,460
+DNA للبشر بحيث إنه بأي أسلوب أو بأي يعني عدسة
+
+4
+00:00:22,460 --> 00:00:27,980
+مكبرة مستخدمة ممكن نلاقي درجات من الاختلافات في
+
+5
+00:00:27,980 --> 00:00:33,870
+الـ SNAPاللي هي Single Nucleotide Polymorphism فهي
+
+6
+00:00:33,870 --> 00:00:40,610
+بتكون على مستوى حرف واحد يعني على مستوى إذا
+
+7
+00:00:40,610 --> 00:00:50,090
+بتخيلنا الـ… الـGenome كل الـ… كل القصائد باللغة
+
+8
+00:00:50,090 --> 00:00:56,450
+العربية مثلا الـ… البروتين هو قصيدة محددة البروتين
+
+9
+00:00:56,450 --> 00:01:01,750
+بتكون من أحرفماشي لأن القصيدة تتكوّن من أبيات
+
+10
+00:01:01,750 --> 00:01:09,050
+والأبيات تتكوّن من أحرف فالـ… الـ Un-SNP هو اختلاف
+
+11
+00:01:09,050 --> 00:01:14,910
+في حرف واحد واتفقنا على إنه تقريبًا نتكلم على إنه
+
+12
+00:01:14,910 --> 00:01:19,570
+في حوالي من خمس إلى عشر مليون SNP عادةً في أي
+
+13
+00:01:19,570 --> 00:01:22,330
+جينوم بشري يعني
+
+14
+00:01:25,820 --> 00:01:34,280
+هي على مستوى الحرف الدقيق اللي هو المحدد يعني أما
+
+15
+00:01:34,280 --> 00:01:41,980
+لما نيجي نتكلم عن بالنسبة لـ… نيجي نتكلم على
+
+16
+00:01:41,980 --> 00:01:49,360
+مستويات أوسع من الـ… من الـVariation أو الاختلافات
+
+17
+00:01:49,360 --> 00:01:55,370
+ونشوف على مستوى أكبرأنا باعتبر هذا الـ «سلايد» من
+
+18
+00:01:55,370 --> 00:02:01,550
+أهم الـ «سلايدات» إذا بدي حد يقول فاهمان إشي يكون
+
+19
+00:02:01,550 --> 00:02:08,910
+منتبه له لما نيجي ندرس على مستوى الـ «كروموزوم»
+
+20
+00:02:08,910 --> 00:02:15,210
+كله والـDNA كله والجينوم كله هيك بشكل عام يعني
+
+21
+00:02:15,210 --> 00:02:21,650
+نعتبره بشكل مش دقيق كثير مش على مستوى الأحرار
+
+22
+00:02:22,150 --> 00:02:25,590
+بسميهم الـ Standard Karyotyping وحكيت لكم كيف
+
+23
+00:02:25,590 --> 00:02:29,750
+بيكون وبيكون على المستوى العشرة أو التسعة الـ
+
+24
+00:02:29,750 --> 00:02:33,890
+Nucleotide Base Pairs كلهم يعني المليارات مرة
+
+25
+00:02:33,890 --> 00:02:39,710
+واحدة هذا الـ Karyotyping إذا بتطلع على الـ Bands
+
+26
+00:02:39,710 --> 00:02:44,250
+اللي بشوفه باستخدام صبغات يا أما Routine Binding
+
+27
+00:02:44,250 --> 00:02:48,530
+أو High Resolution Binding يعنيبشوف الذفاقات
+
+28
+00:02:48,530 --> 00:02:53,330
+الموجودة على الكرموزومات وبحاول أدرسها في مستوى
+
+29
+00:02:53,330 --> 00:02:57,770
+أدق شوية، بعدين في عندى techniques هنا مجموعة
+
+30
+00:02:57,770 --> 00:03:05,530
+بالنص من أصعب الأشياء ويمكن لكل تشخيص فيه علية
+
+31
+00:03:05,530 --> 00:03:10,130
+معينة نستخدمها، اللي هي الـFish
+
+32
+00:03:10,130 --> 00:03:15,000
+والـMicrochromosome الـMicroarrayيعني هنا كأنه أنا
+
+33
+00:03:15,000 --> 00:03:22,440
+بصير أبحث في القصائد بشكل نسميهم أبيات شعر معينة
+
+34
+00:03:22,440 --> 00:03:27,820
+مثلا يمكن أصير تان فيهم نفس البيت أو إشي زي هيك
+
+35
+00:03:27,820 --> 00:03:32,220
+يعني مجموع أكبر شوية من هنا نبحث على لحظة محددة
+
+36
+00:03:32,670 --> 00:03:36,310
+وفيه لما أنا قاعد أفحص على مستوى الـ…
+
+37
+00:03:36,310 --> 00:03:40,990
+الـNucleotide والـBase Pair كل واحد لوحده بسوي
+
+38
+00:03:40,990 --> 00:03:44,790
+Whole Genome Sequencing هذه بيكون الـResolution
+
+39
+00:03:44,790 --> 00:03:50,550
+لحد واحد الـNucleotide تصير أخرها واحد واحد فهذه
+
+40
+00:03:50,550 --> 00:03:56,910
+يعني كل واحد منهم مفيد في حالة معينة، في تشخيص
+
+41
+00:03:56,910 --> 00:04:03,130
+معين، في مرض معين، لما يكون عندي مشاكلعلى شكل
+
+42
+00:04:03,130 --> 00:04:08,110
+مثلًا زي Down Syndrome لأ، المشكلة عادةً إنه
+
+43
+00:04:08,110 --> 00:04:14,750
+كروموزوم كامل فيه زيادة Trisomy 21 مثلًا بينما
+
+44
+00:04:14,750 --> 00:04:19,530
+مثلًا إذا بدور على مرض آخر يمكن أعمل Whole Genome
+
+45
+00:04:19,530 --> 00:04:25,490
+Sequencing فهذه باعتبره من أهم الـSlidesاللي لازم
+
+46
+00:04:25,490 --> 00:04:30,810
+واحد يتخيله ويعرفه ويعرف أمثلة عليه وشو وليش
+
+47
+00:04:30,810 --> 00:04:37,150
+بنحتاج في هذه الطريقة فالآن هاي اللي سموها الـ
+
+48
+00:04:37,150 --> 00:04:44,270
+Ideogram الـ G-banding النطاقات اللي هم الموجودين
+
+49
+00:04:44,270 --> 00:04:51,850
+على الـ كروموزومات لما نكون في مرحلة الـ Metaphase
+
+50
+00:04:51,850 --> 00:04:58,490
+من الـمن الـ Cell Division وبكون الـ DNA على شكل
+
+51
+00:04:58,490 --> 00:05:07,850
+DNA compressed يعني مضغوط وبكون على شكل أصغر إشي
+
+52
+00:05:07,850 --> 00:05:16,430
+حتى نقدر نقسم الـ الـ الـ two sets of chromosomes
+
+53
+00:05:16,430 --> 00:05:25,360
+to each cell فهذه بتكون كيف بتكون؟هنا رؤية أدق
+
+54
+00:05:25,360 --> 00:05:30,860
+ومقربة أكثر للـChromosome والـBands اللي موجودة
+
+55
+00:05:30,860 --> 00:05:36,020
+عليها وتقسيماتها وفيه High Resolution Banding يعني
+
+56
+00:05:36,020 --> 00:05:42,520
+حتى بيعطينا عدد أكبر من الدقة لنشوفه هون احنا
+
+57
+00:05:42,520 --> 00:05:48,020
+بنستخدم تقنية الـFish الـFluorescence اللي هي إنه
+
+58
+00:05:48,020 --> 00:05:54,880
+فيه صبغةبشيع عليها ضوء معين تعطيني ضوء ثاني فعادة
+
+59
+00:05:54,880 --> 00:06:00,000
+نختار أنواع الصدقات اللي بتعطينا فيها الـ Same
+
+60
+00:06:00,000 --> 00:06:04,240
+Excitation Wavelength للـ Laser أو للـ Light
+
+61
+00:06:04,240 --> 00:06:08,420
+وبتعطينا Different Emission Wavelength حتى أقدر
+
+62
+00:06:08,420 --> 00:06:16,500
+أميز أيش اللي بشوفه الـ Die هنا أنا حاططها على
+
+63
+00:06:16,500 --> 00:06:24,410
+ropeبتروح، بتدور على certain DNA sequence أنا مهتم
+
+64
+00:06:24,410 --> 00:06:32,510
+فيه، فهنا يعني أنا بدور الـ «قول» نثّلها على بيت
+
+65
+00:06:32,510 --> 00:06:40,370
+شعر معين في القصائد فبربط عليه مادة ملونة وبحطها
+
+66
+00:06:40,370 --> 00:06:44,550
+على الخلايا
+
+67
+00:06:44,550 --> 00:06:49,120
+اللي هي في حالةالـ Metaphase ويكون عندك روموزومات
+
+68
+00:06:49,120 --> 00:06:55,200
+وبحاول أشوف وين في اتصاق لهذه الـ Prop بالإيش
+
+69
+00:06:55,200 --> 00:06:59,640
+المركفق لها يعني إتلاقي البيت اللي أنا دورت عليه
+
+70
+00:06:59,640 --> 00:07:04,860
+من الشعب عشان تلزق عليه كمجموعة طويلة شوية مش
+
+71
+00:07:04,860 --> 00:07:11,000
+Single Nucleotide وهنا مرة بتاعة بنعتبرها إيجابي
+
+72
+00:07:11,000 --> 00:07:16,530
+ومرة بنعتبرها أساسيةهنا مثلاً الـ Binding تبع الـ
+
+73
+00:07:16,530 --> 00:07:23,810
+X-Chromosome ماشي وهكذا يكون شكله ويكون فيه حالات
+
+74
+00:07:23,810 --> 00:07:29,270
+مختلفة واشياء مختلفة الـ Microarray برضه يعني
+
+75
+00:07:29,270 --> 00:07:34,410
+فكرتها الأهم شيء الواحد ياخذها أن هنا أنا بدور على
+
+76
+00:07:34,410 --> 00:07:44,030
+بشكل عام علىالقطع DNA، يعني Sequence معين بيمكن
+
+77
+00:07:44,030 --> 00:07:51,410
+مثلًا خمسين، مائة Base محددة بترتيب معين يعني أحرف
+
+78
+00:07:51,410 --> 00:07:58,490
+معينة بتكون بشكل معين فهذه بدنا يعني تستطيع الواحد
+
+79
+00:07:58,490 --> 00:08:05,090
+يستخدمها ويدرس الموضوع وهي مفيدة إنه يتخيلها
+
+80
+00:08:05,090 --> 00:08:09,960
+الواحدفي تشريس حالة محددة، راح نحكي عن أنسلتها
+
+81
+00:08:09,960 --> 00:08:17,000
+وكيف تكون في سؤال من الدكتورة هديل، بتتكلم، بتسأل
+
+82
+00:08:17,000 --> 00:08:20,620
+يعني هل نعتبر الـSnips من ضمن الـPolymorphism
+
+83
+00:08:20,620 --> 00:08:24,540
+والـSubstitution ضمن الـMutation علما إن الأتنين
+
+84
+00:08:24,540 --> 00:08:29,260
+بيصير فيهم Single Base يعني؟ لأ، لأ، اسمعلي، كلمة
+
+85
+00:08:29,260 --> 00:08:38,990
+Polymorphism تعدد الصور، ماشي، هيالحالة عندما يكون
+
+86
+00:08:38,990 --> 00:08:47,790
+نسبة حدود هذه الطفرة ماشية أكثر من 1% من الـHuman
+
+87
+00:08:47,790 --> 00:08:54,510
+population يعني كلمة الـMutation okay يعني اللي هي
+
+88
+00:08:54,510 --> 00:08:59,890
+قضية كلمة إنه يقول طفرة الطفرة بدل واحد يعني يكون
+
+89
+00:08:59,890 --> 00:09:06,860
+متأكد أول شيء إنه هو تغير عن الطبيعي فيمكنأنا إذا
+
+90
+00:09:06,860 --> 00:09:11,260
+ما عندي دراسة كاملة لكل البشر بحيث أنا أعرف شهود
+
+91
+00:09:11,260 --> 00:09:18,400
+طبيعي حتى أقرر شهود مش طبيعي هنا بتصير الأمور يعني
+
+92
+00:09:18,400 --> 00:09:27,420
+صعبة شوية لتقييمها بينما عندما نتكلم عن كلمة كانت
+
+93
+00:09:27,420 --> 00:09:33,800
+ضمن تعريف الـPolymorphism إن نسبة حدوث هذه الظاهرة
+
+94
+00:09:34,510 --> 00:09:42,850
+بتكون بنسبة أكتر من 1% من الـ Population لما نتكلم
+
+95
+00:09:42,850 --> 00:09:50,430
+عن Snip، بالذات على مكان محدد، في محل محدد، في
+
+96
+00:09:50,430 --> 00:09:56,150
+دراسة معينة، ماشي عند مشاهدتها، بدنا نسميها Snip
+
+97
+00:09:56,150 --> 00:10:02,090
+هي كلهم أنواع تفرع الاختلاف
+
+98
+00:10:02,090 --> 00:10:08,390
+أنه حكيناالأنواع التانية من الـ Mutation اللي هي
+
+99
+00:10:08,390 --> 00:10:15,730
+إنها قطعة كبيرة تتكرر، قطعة كبيرة تنقلب تنسي إلى
+
+100
+00:10:15,730 --> 00:10:22,950
+inversion، قطعة كبيرة تنحذف، هاي في الغالب يعني
+
+101
+00:10:22,950 --> 00:10:27,890
+تأثيرها شديد على وظيفة الـ Protein والجين المعني
+
+102
+00:10:27,890 --> 00:10:35,680
+في هذه الظاهرة أو في هذه القطعةبينما لما نتكلم على
+
+103
+00:10:35,680 --> 00:10:41,940
+الـ SNP بالذات لدى الواحد يتذكر إن هما أشعة أنواع
+
+104
+00:10:41,940 --> 00:10:46,600
+التفرات أو أشعة أنواع الـ Mutations اللي بتحدث
+
+105
+00:10:46,600 --> 00:10:50,900
+ولكن قد يكون في أحيان كتيرة مالهاش قيمة يعني
+
+106
+00:10:50,900 --> 00:10:58,180
+وظيفياً هي غير فاعلة وغير مسببة لمرضيعني شغل
+
+107
+00:10:58,180 --> 00:11:02,720
+موجودة في الـ «DNA» على اتبين الاختلاف بين الـ
+
+108
+00:11:02,720 --> 00:11:07,480
+«DNA» تبع الأب من الأم في جيم معين بمكان معين وليس
+
+109
+00:11:07,480 --> 00:11:12,780
+بالضرورة أن ينتج عنها اختلال في وظيفة أو شكل أو
+
+110
+00:11:12,780 --> 00:11:16,540
+تركيب البروتين الناتج إن شاء الله أن الأمر واضح
+
+111
+00:11:16,540 --> 00:11:22,080
+دكتور، هي بتسأل برضه إنه يعني الفرق بين
+
+112
+00:11:22,080 --> 00:11:25,380
+الـMutation والـPolymorphism هو النسب؟
+
+113
+00:11:28,000 --> 00:11:36,580
+الإثنين تقريبًا مترادفان يعني نسب تعتبر يعني
+
+114
+00:11:36,580 --> 00:11:42,280
+التعدد الصور بافتراض إنه يعني مثلًا أنا في مكان
+
+115
+00:11:42,280 --> 00:11:46,720
+معين عندي صور تاني، ثلاثة بين البشر، ماشي الطفرة
+
+116
+00:11:46,720 --> 00:11:51,400
+إذا في شيء كان الأصل يكون موجود و بعدين صارت
+
+117
+00:11:51,400 --> 00:11:54,720
+تغيّر، اختلاف
+
+118
+00:11:55,130 --> 00:12:01,570
+بين الوالدين والإبن أو البنت يعني إنه تغير شيء صار
+
+119
+00:12:01,570 --> 00:12:08,470
+يتطور لما نستخدم polymorphism يعني حتى يعني يعرفوه
+
+120
+00:12:08,470 --> 00:12:15,790
+بشكل أكتربيقول إن نسبته كتفرة في المجتمع أو في
+
+121
+00:12:15,790 --> 00:12:20,890
+اللي عندها قيام بالدراسة أكثر من 1% يعني الأقل من
+
+122
+00:12:20,890 --> 00:12:25,190
+1% لا تُعتبر Polymorphism يعني هيك مرات تعتبروها
+
+123
+00:12:25,190 --> 00:12:33,030
+بس الـSNP يعني هو هنا ما ممكنش نعتبره Polymorphism
+
+124
+00:12:33,030 --> 00:12:38,150
+لجين معين يعني مع أنه كلمة Polymorphism داخل فيه
+
+125
+00:12:38,150 --> 00:12:47,110
+يعنيسلانه قد لا يكون دقيق ماشي أنا راحة صورتي
+
+126
+00:12:47,110 --> 00:12:55,240
+بعرفش أوي بده أشوف وين أناعشان… ما هو اسمه؟ المهم،
+
+127
+00:12:55,240 --> 00:13:00,320
+طبعاً برضه لسه يعني وضحة النقطة بالنسبة لها بس
+
+128
+00:13:00,320 --> 00:13:05,460
+يعني بتقول إنه حتى الطفرات اللي بقطعة كبيرة زي
+
+129
+00:13:05,460 --> 00:13:09,440
+الـCopy Number Variant ممكن مايكونش لها قيمة لو
+
+130
+00:13:09,440 --> 00:13:15,800
+كانت non-coding region لما نخطط بالشكل الصحيح
+
+131
+00:13:15,800 --> 00:13:25,530
+طبعاًوهذه يعني من الـ نسميها من الظواهر اللي تعطي
+
+132
+00:13:25,530 --> 00:13:33,050
+الإنسان خاصية أكتر إنه الـ DNA عنده بتتحمل إنه
+
+133
+00:13:33,050 --> 00:13:40,510
+يكون هناك فترات كثيرة بس إذا في مكانمالوش قيمة،
+
+134
+00:13:40,510 --> 00:13:45,250
+صح، مش راح يكون له قيمة الدكتورة أسماء برضه يعني
+
+135
+00:13:45,250 --> 00:13:49,610
+بتطلب إذا كان فيه ممكن شرح الـSlider رقم 7 مش عارف
+
+136
+00:13:49,610 --> 00:13:53,810
+أيه قصدها في المحاضرة هذه وصلت دكتور أنت للـSlider
+
+137
+00:13:53,810 --> 00:14:01,650
+رقم 7 في المحاضرة؟ والله الـSlider رقم 7 اللي هو
+
+138
+00:14:01,650 --> 00:14:03,710
+الـMicro Array
+
+139
+00:14:06,230 --> 00:14:11,190
+الـ «هذا ما تاخدوش تفاصيل الـ «هذا ما تاخدوش
+
+140
+00:14:11,190 --> 00:14:12,470
+تفاصيل الـ «هذا ما تاخدوش تفاصيل الـ «هذا ما
+
+141
+00:14:12,470 --> 00:14:12,550
+تاخدوش تفاصيل الـ «هذا ما تاخدوش تفاصيل الـ «هذا
+
+142
+00:14:12,550 --> 00:14:13,290
+ما تاخدوش تفاصيل الـ «هذا ما تاخدوش تفاصيل الـ
+
+143
+00:14:13,290 --> 00:14:14,490
+«هذا ما تاخدوش تفاصيل الـ «هذا ما تاخدوش تفاصيل
+
+144
+00:14:14,490 --> 00:14:14,990
+الـ «هذا ما تاخدوش تفاصيل الـ «هذا ما تاخدوش
+
+145
+00:14:14,990 --> 00:14:15,050
+تفاصيل الـ «هذا ما تاخدوش تفاصيل الـ «هذا ما
+
+146
+00:14:15,050 --> 00:14:23,090
+تاخدوش تفاصيل الـ «هذا ما تاخدوش تفاصيل الـ «هذا
+
+147
+00:14:23,090 --> 00:14:35,750
+ما تاخدوش تفاص
+
+148
+00:14:35,860 --> 00:14:42,080
+اللي بتدور على الخلل اللي أنا بتوقع يكون موجود،
+
+149
+00:14:42,080 --> 00:14:46,900
+ماشي؟ ربما مش قصد عن الـSlider هذه، تقصد الـSlider
+
+150
+00:14:46,900 --> 00:14:51,300
+اللي بعدها كمان هدولة نفس الفكرة، يعني
+
+151
+00:14:51,300 --> 00:14:55,100
+الـMicroarrays،
+
+152
+00:14:55,100 --> 00:15:03,600
+ماشي؟ يعني هنا إذا أنا مش يعني أحكي لكم قصص، ماشي؟
+
+153
+00:15:04,330 --> 00:15:12,550
+في أنا الفترة الأخيرة التقيت بعائلة إخواننا من
+
+154
+00:15:12,550 --> 00:15:19,530
+سوريا لاجئين في القردن يعني فعندهم حالة هجيبلكم
+
+155
+00:15:19,530 --> 00:15:27,150
+صورة إيديهم وجريهم المحاضرة الجاية ماشي عليهم يعني
+
+156
+00:15:27,150 --> 00:15:33,790
+إشي غريب جداً أقرب شيء وإذا حدا بينكم بيحاول يشوفه
+
+157
+00:15:34,230 --> 00:15:41,570
+اسمه «Infantile Digital Fibromatosis» يعني عبارة
+
+158
+00:15:41,570 --> 00:15:46,930
+عن خلّيني أنا أبعتلك الصورة يا دكتور أحمد على
+
+159
+00:15:46,930 --> 00:15:53,110
+الـWhatsApp إلىك، ماشي؟ إن شاء الله ولمّا تيجي
+
+160
+00:15:53,110 --> 00:15:59,610
+أعرضها عندك بإذن الله يا تعالى فهدولة العائلة هذه
+
+161
+00:16:00,220 --> 00:16:05,620
+الوالد والوالدة درجة أولى أقارب ولاد عم ولاد خالة
+
+162
+00:16:05,620 --> 00:16:11,380
+يعني فيه قرابة والشغل
+
+163
+00:16:11,380 --> 00:16:19,900
+التاني أنه عبارة عن هما تسع أخوة وأخوات أربعة
+
+164
+00:16:19,900 --> 00:16:29,730
+مصابين وأربعة مش مصابين، ماشي؟فهينبعدتلك الصور أنت
+
+165
+00:16:29,730 --> 00:16:38,410
+دخلهم للشباب والدكتورات فالآن
+
+166
+00:16:38,410 --> 00:16:46,330
+أنا شاكك بشكل كبير جداً أن هذا مرض وراقي وأشك أنه
+
+167
+00:16:46,330 --> 00:16:57,390
+يعني إذا كان منديلي يعني كانناتج عن خلل في جين
+
+168
+00:16:57,390 --> 00:17:04,470
+واحد ماشي بيكون autosomal
+
+169
+00:17:04,470 --> 00:17:10,030
+dominant لأن الذكور والإناث زي بعض مافيش اختلافات
+
+170
+00:17:10,030 --> 00:17:20,090
+بينهموالشغل التاني أنه الكل يعني ال .. ال .. ال ..
+
+171
+00:17:20,090 --> 00:17:24,390
+بالنسبة لل .. أنه كل الأفراد يعني فيه بكور وفيه
+
+172
+00:17:24,390 --> 00:17:31,370
+إينات ومن العائلة بالكامل فيه ناس فيهم مصابين ففي
+
+173
+00:17:31,370 --> 00:17:38,210
+مثل هيك حالة شاورت مع تعيين الأمراض الوراثية عندنا
+
+174
+00:17:39,120 --> 00:17:47,020
+المشكلة أنه أنا ماعندي تخيل سابق لوين الأنول الجين
+
+175
+00:17:47,020 --> 00:17:51,320
+المسؤول عن هذه الظاهرة ماعندي أي تخيأ فكرة سابقة
+
+176
+00:17:51,320 --> 00:17:55,820
+أنول البروتين، أنول الجين، يعني لو أنا والله عند
+
+177
+00:17:55,820 --> 00:17:59,200
+إنسان عنده مشكلة بالـHemoglobin أنا بعرف إن
+
+178
+00:17:59,200 --> 00:18:03,800
+الـAlpha والـBeta Chain تبعات الـHemoglobin هم
+
+179
+00:18:03,800 --> 00:18:08,560
+اللي بيبقوا codes for this problem فلما أنا ألاقي
+
+180
+00:18:09,110 --> 00:18:14,090
+إنسان أو عيلة فيها مشكلة مش مو… مش عارف أنا
+
+181
+00:18:14,090 --> 00:18:19,310
+ماعنديش أي تخيل وين راح يكون الفرق أو وين راح يكون
+
+182
+00:18:19,310 --> 00:18:23,910
+الخلل الموجود أو سببه لازم أنا من الطرف الحالي هذه
+
+183
+00:18:23,910 --> 00:18:27,850
+أعمل Whole Genome Sequence يعني لازم أقرأ تسع
+
+184
+00:18:27,850 --> 00:18:32,870
+مليارات وأقارن في التسع مليارات بين الناس اللي
+
+185
+00:18:32,870 --> 00:18:39,160
+عندهم مرض واللي ماعندهم مش مرض فاهم عليك إيه؟ففي
+
+186
+00:18:39,160 --> 00:18:43,640
+اللحظة هذه أنا بحتاج لهذا اللوع من البحث إذا عندي
+
+187
+00:18:43,640 --> 00:18:49,020
+تصور سابق مثلًا نحكي على إنه فيه إيش اسمه «Dijord
+
+188
+00:18:49,020 --> 00:18:52,900
+Syndrome» بحكي لكم عنه الـ «Dijord Syndrome» إله
+
+189
+00:18:52,900 --> 00:18:56,800
+يعني التوقع إنه في مكان معين، في الـChromosome
+
+190
+00:18:56,800 --> 00:19:00,250
+الإفلانيفي المنطقة الفلانية، في الـBand الفلانية
+
+191
+00:19:00,250 --> 00:19:06,210
+بس مش لسه Gen ولا Snip أنا بتكلم عنه أنا بتكلم هنا
+
+192
+00:19:06,210 --> 00:19:13,690
+عن قطعة أكبر شوية بيكون فيها خلط فالفكرة
+
+193
+00:19:13,690 --> 00:19:22,530
+اللي بدنا نحكيها اللي هي إنه لما أنا آجي أعمل
+
+194
+00:19:22,530 --> 00:19:25,970
+Whole Genome Sequencing يعني في ظاهرة بنحكي عنها
+
+195
+00:19:25,970 --> 00:19:31,830
+ممكن بعدين بتفاصيلهنا عملية إنه أنا بصير أقطع الـ
+
+196
+00:19:31,830 --> 00:19:36,610
+DNA باستخدام إنزيمات Restriction enzymes أو إنزام
+
+197
+00:19:36,610 --> 00:19:40,710
+معينة Restriction enzymes مرات نستخدمها لما نحكي
+
+198
+00:19:40,710 --> 00:19:45,600
+عن إنه إشي بقطع البروتينبقطعه بأماكن محددة بين كل
+
+199
+00:19:45,600 --> 00:19:50,000
+Two amino acids مثلا بشكل معين يعني فبنفس الفكرة
+
+200
+00:19:50,000 --> 00:19:54,420
+الـ… الـEnzymes التبعات اللي بتساوي الـDigestion
+
+201
+00:19:54,420 --> 00:20:00,420
+للـDNA عشان نعمله بقطع معينة يكون فيها Overlap
+
+202
+00:20:00,420 --> 00:20:05,800
+نقدر نرسم صورة عن الجميع وبتكون في الحالة هذه أنا
+
+203
+00:20:05,800 --> 00:20:10,440
+بحاجة أعمل Whole Genome Sequence Analysis وبعدين
+
+204
+00:20:10,440 --> 00:20:16,790
+بسير أدورعلى 9 مليارات وين فيه اختلافة بين المصاب
+
+205
+00:20:16,790 --> 00:20:25,050
+وبين السليم يعني هي الفكرة تبعها في أسئلة الـ
+
+206
+00:20:25,050 --> 00:20:39,030
+هنا حكينا إنه تقريبًا تقريبًا يعني 0.6، 0.7% من
+
+207
+00:20:39,030 --> 00:20:46,880
+الـ newbornماشي، بكون فيه لما تعمل Carrier Type
+
+208
+00:20:46,880 --> 00:20:53,220
+بكون فيه عندك روموزوم الـ Anomalous يعني نص
+
+209
+00:20:53,220 --> 00:20:59,220
+بالمية، نعتبرها الجد يعني يعني كل 200 جنين واحد
+
+210
+00:20:59,220 --> 00:21:06,470
+بيطلع فيه عنده مشكلة على مستوى روموزوم كامليعني
+
+211
+00:21:06,470 --> 00:21:12,510
+تعتبر قطعة كبيرة جداً من الـDNA فحدوث اختلالات في
+
+212
+00:21:12,510 --> 00:21:18,850
+الـChromosomes وارد، موجود، مؤثر، بدنا نعرف إنه
+
+213
+00:21:18,850 --> 00:21:23,050
+موجود الـChromosome،
+
+214
+00:21:23,050 --> 00:21:30,050
+هذه النسبة اللي هي تقريباً 0.5، 0.6% لسه لو ده
+
+215
+00:21:30,050 --> 00:21:35,100
+ناخذ الـStilbirds، ناخذ الـAbortionsالإيجادات
+
+216
+00:21:35,100 --> 00:21:42,020
+الذاتية في أشهر الحملة الأولى هذه بتكون نسبتها
+
+217
+00:21:42,020 --> 00:21:48,960
+عالية وبتكون موجودة، ماشي فحتى بتكون نسبتها أعلى
+
+218
+00:21:48,960 --> 00:21:54,300
+من هذه النسبة يعني هذه newborn يعني ولادة صارت أنه
+
+219
+00:21:54,300 --> 00:22:01,860
+ولد طبيعي يعني فهذه النسب موجودة بس في ظاهرة أخرى
+
+220
+00:22:01,860 --> 00:22:09,580
+أنه أحياناً الخللإنه أنسختين للـ Chromosome صار
+
+221
+00:22:09,580 --> 00:22:14,680
+انتقال لقطع كبيرة من محل لمحل ثاني من الـ
+
+222
+00:22:14,680 --> 00:22:20,420
+Chromosome الأول فصار صغير أو قصير للـ Chromosome
+
+223
+00:22:20,420 --> 00:22:29,180
+الثاني اللي صار حجمه أكبر فهذه الظاهرة هي تسمى الـ
+
+224
+00:22:29,180 --> 00:22:36,810
+Balanced Translocation يعني اختلالفي مكان القطعة
+
+225
+00:22:36,810 --> 00:22:46,170
+الكبيرة بحيث إنه بالمحصلة المادة الوراثية تبع هذا
+
+226
+00:22:46,170 --> 00:22:52,550
+الإنسان بتكون كاملة، بتكون طبيعية الـTotal طبيعي،
+
+227
+00:22:52,550 --> 00:23:01,890
+بس مكانه غلط فلما يكون وجود Balance Translocation
+
+228
+00:23:01,890 --> 00:23:11,630
+ماشيهذه بتكون نتيجتها إن نفس الشخص هذا بيكون طبيعي
+
+229
+00:23:11,630 --> 00:23:19,670
+بس إنه بالنسبة للـ «بروجينيت» تبعته ولاده وبناته
+
+230
+00:23:19,670 --> 00:23:26,450
+بعدين راح تصير فيه إشكاليات إنه لما يصير الخلايا
+
+231
+00:23:26,450 --> 00:23:30,050
+المطلوبة منها تنقص بشكل سليم في بعض الخلايا راح
+
+232
+00:23:30,050 --> 00:23:36,530
+تكونعند DNA ناقص ويمكن هذا يكون غير حي ولا يعيش
+
+233
+00:23:36,530 --> 00:23:41,250
+وإنه يكون فيه إيش زايد يكون يعطينا مرض هاي قضية
+
+234
+00:23:41,250 --> 00:23:45,610
+الـStructural Abnormalities وهمية إن تكون Balanced
+
+235
+00:23:45,610 --> 00:23:50,470
+أو Unbalanced وكيف تأثيرها الشغل الثاني الـ
+
+236
+00:23:50,470 --> 00:23:56,610
+Unemployed يعني اختلال عدد نسخ وكمية
+
+237
+00:23:56,610 --> 00:24:01,550
+الـChromosomesاللي هي راح نحكي عنها عملية عدم
+
+238
+00:24:01,550 --> 00:24:07,710
+انتصال الـChromosomين عن بعض بشكل سليم وبالذات هي
+
+239
+00:24:07,710 --> 00:24:11,930
+أكثر للـXY-Chromosome بس ممكن حتى في
+
+240
+00:24:11,930 --> 00:24:17,690
+الـChromosomات التانية في أسلة هنا
+
+241
+00:24:17,690 --> 00:24:24,450
+ليستة أرجو أنكم تحفظوها يعني لما تيجي تقرا و بعدين
+
+242
+00:24:27,860 --> 00:24:35,400
+التقارير عن أي مرض وتحاولوا تفهموا شو اللي بيحكوا
+
+243
+00:24:35,400 --> 00:24:40,060
+عنه كحدث اللي حصل على مستوى المادة الورافية والـ
+
+244
+00:24:40,060 --> 00:24:47,180
+DNA وكيف صار، فإذا كتبوا الديل «Deletion»إذا كان
+
+245
+00:24:47,180 --> 00:24:51,540
+حاطين إشارة زائد فإنه صار زيادة في الوظيفة أو
+
+246
+00:24:51,540 --> 00:24:58,120
+نقصان في الوظيفة أو هناك يعني في نفس الجسم خلايا
+
+247
+00:24:58,120 --> 00:25:02,560
+بتكون بشكل وخلايا ثانية بتكون بشكل آخر إنه بيكون
+
+248
+00:25:02,560 --> 00:25:09,020
+فعلا مزيكيزم مزيق ماشي اللي هي إنه يعني زي الـ
+
+249
+00:25:11,210 --> 00:25:16,310
+الأنظمة أو الشكل إنه بيكون من أكثر من نوع مثلا من
+
+250
+00:25:16,310 --> 00:25:21,990
+بلاط بلاط لون معين وبلاط لون تاني مثلا قضية الـ
+
+251
+00:25:21,990 --> 00:25:26,550
+Translocation روبرسين Translocation Rain
+
+252
+00:25:26,550 --> 00:25:30,890
+Chromosome يعني الأشياء اللي موجودة هذه جدول
+
+253
+00:25:32,000 --> 00:25:39,080
+كمصطلحات لأ مهم وكويس الواحد يفهمه عشان لما نقرأ
+
+254
+00:25:39,080 --> 00:25:45,260
+يعني هنا كمثال لكل واحد منهم شو معناه وشو بدل على
+
+255
+00:25:45,260 --> 00:25:54,580
+إيش أن نكون بذلك الشكل هاي كمان يعني أسلوب يعني
+
+256
+00:25:54,580 --> 00:26:03,070
+لما نحطونا رسمات زي هيك ماشي هو بيحطنماذج مختلفة
+
+257
+00:26:03,070 --> 00:26:11,750
+للتجارب المخبرية لتشكيص هذه الحالة فالـ Trisomy 21
+
+258
+00:26:11,750 --> 00:26:19,170
+اللي هو Down Syndrome ماشي، الـ Trisomy 21 ممكن
+
+259
+00:26:19,170 --> 00:26:25,690
+أنا في الـ A حطيت اللي هو Karyotype فأنا بشغته
+
+260
+00:26:25,690 --> 00:26:33,220
+بهذا الشكلهذه كريوتيب وبيكون برائيسوم 21 ممكن أنا
+
+261
+00:26:33,220 --> 00:26:39,280
+أستخدم الـ Fluorescence Fish اللي هي Fluorescence
+
+262
+00:26:39,280 --> 00:26:45,720
+In Cytohybridization for Chromosome 21 ويعني هنا
+
+263
+00:26:45,720 --> 00:26:51,360
+بيطلع ليه إن أنا عندي تلت نسخة ماشي يعني يمكن هو
+
+264
+00:26:51,360 --> 00:26:56,960
+الأحمر فبكون إنه في هذه الخليةبكون عندي ثلاث نسخ
+
+265
+00:26:56,960 --> 00:27:00,980
+من هذا الأحمر كروموزوم ثاني عشان أتأكد إن أنا شغلي
+
+266
+00:27:00,980 --> 00:27:07,700
+مظبوط خطيت عليه صبغة خضراء وبالتالي انبين عندي إن
+
+267
+00:27:07,700 --> 00:27:12,520
+أنا في نسختين أنا مش أنا بالغلط صار Overlap بين
+
+268
+00:27:12,520 --> 00:27:18,440
+خليتين وفي حياتي إنه بعندي أنا أكتر من نصفة يعني
+
+269
+00:27:18,440 --> 00:27:24,850
+من زيادة من خلية أكتر من خليةفهنا، هاي نوع من الـ
+
+270
+00:27:24,850 --> 00:27:29,250
+FISH اللي هو In-Situ Hybridization تستخدمان تقنيات
+
+271
+00:27:29,250 --> 00:27:36,350
+مختلفة فاللي بعدها، اللي دلوقت يقرا اللي هو
+
+272
+00:27:36,350 --> 00:27:39,470
+Chromosomal
+
+273
+00:27:39,470 --> 00:27:44,750
+Microarray واستخدام
+
+274
+00:27:44,750 --> 00:27:49,790
+يعني اللي هو الـMicroarrays اللي هي الأسلوب الثالث
+
+275
+00:27:51,810 --> 00:28:00,170
+بشوف هنا الكروموزومات تبع الإنسان والأصل اللي هي
+
+276
+00:28:00,170 --> 00:28:07,530
+2M يعني النسختين من الـ من الـ الـ DNA ولا
+
+277
+00:28:07,530 --> 00:28:11,930
+الكروموزوم بتكون في هذا النطاق حسب هذا الفحث بلاقي
+
+278
+00:28:11,930 --> 00:28:19,430
+هنا الكروموزوم 21 عالي كتيروعرفت أنه يعني ثلاث نسخ
+
+279
+00:28:19,430 --> 00:28:24,570
+بدل ما هو من نسختين العادى لو كان فيه مثلا نفترض
+
+280
+00:28:24,570 --> 00:28:30,810
+أنا شخصيت «تيرنر سندروم» ما تعرفوا عنه يكون XO
+
+281
+00:28:30,810 --> 00:28:34,610
+يكون «one copy of X» باجي لو باجي بعمل
+
+282
+00:28:34,610 --> 00:28:38,410
+الـ«microarray» هذا باستخدم للـX-Chromosome كان
+
+283
+00:28:38,410 --> 00:28:43,580
+بلاقي الطفل هذه أو الإنسان هذه جاي يروحبتلاقي إذا
+
+284
+00:28:43,580 --> 00:28:47,720
+كان فوق معناته زيادة إذا كان تحت معناته فيه نقص
+
+285
+00:28:47,720 --> 00:28:55,960
+فهي الفكرة هنا كله لنفس التشخيص لنفس الظاهرة ولكن
+
+286
+00:28:55,960 --> 00:29:03,680
+باستخدام وسائل مخبرية مختلفة يعني كل واحد منهم إيه
+
+287
+00:29:03,680 --> 00:29:07,900
+إيجابيات وإيه سلبيات إيه نقاط قوة بس فيه إيه نقاط
+
+288
+00:29:07,900 --> 00:29:12,680
+ضعفوضروري الواحد ينتبه لهذه الأشياء لما يفكر كيف
+
+289
+00:29:12,680 --> 00:29:22,480
+يشخص هذا الحالة في أسئلة؟ لأن نوعيات الـ
+
+290
+00:29:22,480 --> 00:29:29,920
+Translocation وأنواعها Balanced وUnbalanced وبكون
+
+291
+00:29:29,920 --> 00:29:37,380
+في أن ومكان بين كذا وكذا يعني هذه الظواهر تحدث
+
+292
+00:29:38,300 --> 00:29:45,240
+فيه ظواهر موجودة وأحيانًا يعني في حالات معينة
+
+293
+00:29:45,240 --> 00:29:52,440
+بيكون فيها إلى حتى دور وظيفي للمرض اللي بنشوفه
+
+294
+00:29:52,440 --> 00:29:59,660
+يعني مثلًا المرض من أنواع السرطانات اللي هو
+
+295
+00:29:59,660 --> 00:30:06,260
+«Chronic Myeloid Leukemia» الـ «CML» الـ «CML» من
+
+296
+00:30:06,260 --> 00:30:10,750
+الأشياء المميزة لهاللي هي موضوع بيسموه الـ
+
+297
+00:30:10,750 --> 00:30:13,750
+Philadelphia chromosome الـ Philadelphia
+
+298
+00:30:13,750 --> 00:30:19,630
+chromosome عبارة عن Translocation
+
+299
+00:30:19,630 --> 00:30:27,330
+بين قطعتين من الـ DNA بحيث إنه في الـ PCR اللي هو
+
+300
+00:30:27,330 --> 00:30:32,570
+الـ B cell receptor gene يعني عبارة عن مكان معين
+
+301
+00:30:32,570 --> 00:30:37,230
+في الخلايا الليمباوية الخلايا الليمباوية بس إله
+
+302
+00:30:37,230 --> 00:30:44,600
+دخلفي بقاء الخلايا ومعيشة الخلايا وحياة الخلايا
+
+303
+00:30:44,600 --> 00:30:51,340
+عدم إنها تتوفى بالـ Apoptosis وفي الـ ABL-Gene
+
+304
+00:30:51,340 --> 00:30:56,020
+اللي دخل بالـ Longevity تبعته فهدولة الأصل قطعتين
+
+305
+00:30:56,020 --> 00:30:59,840
+في الـ DNA بعاد عن بعض ولمّا ييجي في الـ
+
+306
+00:30:59,840 --> 00:31:02,340
+Philadelphia chromosome أو في اللي عندهم هذه الـ
+
+307
+00:31:02,340 --> 00:31:06,440
+Genetic Mutation يصيروا جانب بعض وبكون نتيجة
+
+308
+00:31:06,440 --> 00:31:13,110
+اختلالفي وظيفة الخلية فهذه كلها ضواهر يعني أنا أظن
+
+309
+00:31:13,110 --> 00:31:22,750
+إنه الآن المطلوب الفهم العام وليس المقصود التفاصيل
+
+310
+00:31:22,750 --> 00:31:28,950
+حدوث هذه الأشياء لما يكون الـ Translocation
+
+311
+00:31:28,950 --> 00:31:35,390
+والاختلال دلوقتي بقوله Balanced البلاء أقل المرض
+
+312
+00:31:35,390 --> 00:31:42,330
+أخفرإنه على الأقل هذا الإنسان عنده كمية DNA كافية
+
+313
+00:31:42,330 --> 00:31:49,470
+وطبيعية ومتوقعة بس وين تواجدها شرط بطاقة مع بعض
+
+314
+00:31:49,470 --> 00:31:54,670
+كيف علاقتها في بعض هو اللي بيصير خلافات وهذه راح
+
+315
+00:31:54,670 --> 00:31:58,450
+تنتج عندها مشاكل في الذرية تبع هذا الإنسان في
+
+316
+00:31:58,450 --> 00:32:07,590
+ولاده وبناته الـ هنادراسة يعني مهم الواحد يتطلع
+
+317
+00:32:07,590 --> 00:32:15,450
+عليها ويكون يتخيلها على نسبة احتمالات الأمراض
+
+318
+00:32:15,450 --> 00:32:22,210
+الوراثية اللي هي الـ Whole Genome أو Whole
+
+319
+00:32:22,210 --> 00:32:26,490
+Chromosome الدراسة
+
+320
+00:32:26,490 --> 00:32:33,010
+هذه على 10,000 حالة ولادة، ماشي؟
+
+321
+00:32:36,020 --> 00:32:40,660
+ويعني حاطين هنا زي ما ذكرت أكتر شوية من المرة اللي
+
+322
+00:32:40,660 --> 00:32:45,360
+فاتت الـ Spontaneous Abortion والـ Live Born
+
+323
+00:32:45,360 --> 00:32:52,380
+Infant يعني الـ إثنينلو صار Abortion يقضوا يدرسوا
+
+324
+00:32:52,380 --> 00:32:56,340
+كيف وضع الـ «Karyotype» شو اللي نوعين المشكلة
+
+325
+00:32:56,340 --> 00:33:03,700
+الموجودة أو حدوث إجهاد ذاتي
+
+326
+00:33:03,700 --> 00:33:08,520
+spontaneous الآن
+
+327
+00:33:08,520 --> 00:33:13,480
+نشوف كام نسب الاختلالات في الـChromosomes كلها
+
+328
+00:33:13,480 --> 00:33:20,020
+فهنا أنا استخدمتاللي هو بن قوسين الـ Karyotype
+
+329
+00:33:20,020 --> 00:33:28,340
+يعني حتى أطلّع مثل إيه نتاج الحالات
+
+330
+00:33:28,340 --> 00:33:33,440
+اللي عملوها الدراسة هذه، العشر تلات كان 1500
+
+331
+00:33:33,440 --> 00:33:40,940
+abortion، 15% و8500 يعني 85% live birth
+
+332
+00:33:44,320 --> 00:33:50,120
+بالنسبة للـ Live Birds من الـ 8500 فيه خمسين كان
+
+333
+00:33:50,120 --> 00:33:54,220
+عندهم كروموزوم الـ Anomalous بينما بالـ
+
+334
+00:33:54,220 --> 00:34:00,660
+Spontaneous Abortions 750 من الـ 1500 كان عندهم
+
+335
+00:34:00,660 --> 00:34:09,880
+Abnormal Chromosome يعني الـ بالذات في عند حدوث
+
+336
+00:34:09,880 --> 00:34:16,500
+الإجهاب الذاتي المرأة الحاملفي الأشهر الأولى نتكلم
+
+337
+00:34:16,500 --> 00:34:22,220
+حتى غالبًا أول ثلاث أشهر هذه راح يكون في الغالب في
+
+338
+00:34:22,220 --> 00:34:29,720
+أنها Abnormal chromosomal defect يعني مشكلة كبيرة
+
+339
+00:34:29,720 --> 00:34:36,880
+بالنسبة لكل كمية كبيرة من الـ DNA وهذه يعني حتى لو
+
+340
+00:34:36,880 --> 00:34:42,920
+صار Life birth ممكن أحيانًا يكون في نسبة من أمراض
+
+341
+00:34:42,920 --> 00:34:48,940
+مثل ذلكالآن، ما هي أنواع المشاكل اللي بتوقع الواحد
+
+342
+00:34:48,940 --> 00:34:54,020
+أو اللي لقوها في الحلقة؟
+
+343
+00:34:54,020 --> 00:35:01,740
+يعني، مع الـ Abortion 800 حالة Total من الـ 10,000
+
+344
+00:35:01,740 --> 00:35:06,620
+pregnancies يعني 8% كان فيهم الـ Chromosomal
+
+345
+00:35:06,620 --> 00:35:11,040
+Anomalies يعني نسبة محرزة فيه Triploid و
+
+346
+00:35:11,040 --> 00:35:17,180
+Tetraploid يعنيأحنا الأصل للإنسان إن الخلايا
+
+347
+00:35:17,180 --> 00:35:26,440
+التابعتنا فيها 46 زوج ماشي، يعني 23 زوج، 46
+
+348
+00:35:26,440 --> 00:35:38,780
+كروموزوم الـ Triploid يعني تطلع اللي هو 23×3
+
+349
+00:35:38,780 --> 00:35:46,270
+بيصير إنها 69 كروموزومبحيث أنه يكون ثلاث نسخ
+
+350
+00:35:46,270 --> 00:35:51,970
+وTetraploid يعني أنه ضرب بأربعة تلات وعشرين بأربعة
+
+351
+00:35:51,970 --> 00:35:59,170
+يعني بيصير 92 chromosome موجود في الخلايا فهي حدوث
+
+352
+00:35:59,170 --> 00:36:05,370
+مثل ذلك اختلال شديد، ظاهرة موجودة في الـ abortion
+
+353
+00:36:05,370 --> 00:36:11,450
+اللي بيكمل الحمل ما بيكون احتمالي أن يكون عنده مثل
+
+354
+00:36:11,450 --> 00:36:20,370
+ذلك ظاهرةI متوقع يكون موجودة الوفيات أو الـ
+
+355
+00:36:20,370 --> 00:36:26,010
+spontaneous abortions والجاذات كان
+
+356
+00:36:26,010 --> 00:36:34,190
+فيه 140 Turner اللي هو XO بس نصها واحدة من الـ X
+
+357
+00:36:34,190 --> 00:36:40,650
+مافيش Y أو X تانية وبالنسبة للـ Live Birds كان فيه
+
+358
+00:36:40,650 --> 00:36:46,420
+احتمالية واحدةيعني من 10,000 pregnancies بتوقع
+
+359
+00:36:46,420 --> 00:36:57,020
+الواحد واحد Turner يكون يعني موجود يعني، فطلعت
+
+360
+00:36:57,020 --> 00:37:02,540
+الـSlide دكتورة
+
+361
+00:37:02,540 --> 00:37:05,580
+اسمها، إذا بتسأل ممكن توضيح لظاهرة
+
+362
+00:37:05,580 --> 00:37:11,700
+الـIsochromosome عبارة عن إيش هي بتطلع؟من إيش قديم
+
+363
+00:37:11,700 --> 00:37:14,840
+ولا فيها الـ «سلايد»؟ لأ، أعتقد في الـ «سلايد»
+
+364
+00:37:14,840 --> 00:37:25,280
+السابق يعني، «ظاهرة الـ Isochromosome» الأسئلة
+
+365
+00:37:25,280 --> 00:37:30,360
+دا فيها أي واحد عنده سؤال يوقف وقتها، شايف عليه؟
+
+366
+00:37:30,360 --> 00:37:40,310
+يعني الـ «إنفرجل لوبز» والأشكال الأخرى من الـأشكال
+
+367
+00:37:40,310 --> 00:37:45,550
+شكل الكروموزوم وارتباطاتهم مع بعض اللي هم أكتر من
+
+368
+00:37:45,550 --> 00:37:52,050
+شكل ودولة يعني خلّينا اليوم نوقفهم على إنهم أمثلة
+
+369
+00:37:52,050 --> 00:37:59,310
+للاختلالات اللي ممكن تحدث تفاصيل ليش حدثت وكذا
+
+370
+00:37:59,310 --> 00:38:05,690
+اليوم والآن إذا ما إلها نصيب بعدين نرجحها في مرض
+
+371
+00:38:05,690 --> 00:38:11,380
+معين أو إذا نتناقش عن حالة معينةماشي، ما بديش
+
+372
+00:38:11,380 --> 00:38:17,140
+مياها يعني الآن هذه الأشياء اللي هنا يعني الظواهر
+
+373
+00:38:17,140 --> 00:38:25,140
+في اختلال التركيب تبع الـ DNA كـChromosome كشكل
+
+374
+00:38:25,140 --> 00:38:31,320
+كله إذا الاختلال، بالأخير كمية الـ DNA Balance
+
+375
+00:38:31,320 --> 00:38:36,940
+متوازنة مع الطبيعي، بالغالب نفس الشخص ماعندوش
+
+376
+00:38:36,940 --> 00:38:43,070
+مشكلةبس بتسوي مشاكل في ذريته لأنه بترجع الخلايا
+
+377
+00:38:43,070 --> 00:38:46,670
+بده لازم تتقسم بالنص مظبوط فبصير فيه جزء و فيه
+
+378
+00:38:46,670 --> 00:38:52,430
+زيادة و فيه جزء و فيه نقصان يعني هنا الـ «هاي»
+
+379
+00:38:52,430 --> 00:38:58,310
+أمثلة على الأشياء اللي ممكن تحدث الأمثلة
+
+380
+00:38:58,310 --> 00:39:03,230
+على اللي الآن بنحكيها وصلت أنا للـ45XO اللي هو
+
+381
+00:39:03,230 --> 00:39:12,120
+الـTurner هذهيعني في خلل وفي مرض وفي عدم نمو طبيعي
+
+382
+00:39:12,120 --> 00:39:20,920
+ومشاكل كثيرة بس بيظل أنه يعنيبالذات لأن الـ Y
+
+383
+00:39:20,920 --> 00:39:25,840
+-Chromosome مش مهم كثير كان خواص للحياة كثيرة
+
+384
+00:39:25,840 --> 00:39:31,500
+وكذلك الـ X التاني أصلاً بتأثر نصهم في نفس القلاية
+
+385
+00:39:31,500 --> 00:39:34,980
+أو اللي هي الـ Ionization اللي حنا نحكي عنه فهو
+
+386
+00:39:34,980 --> 00:39:39,020
+يعتبر شيء خفيف يعني هو أشياء واحدة في مرات بيكون
+
+387
+00:39:39,020 --> 00:39:47,020
+ممكن أنه يكون الإنسانيكمل لإنه يتم ولادته «Trisomy
+
+388
+00:39:47,020 --> 00:39:54,120
+16» و«Trisomy 18» بتحدث بالنسبة أكبر بكتير بالـ
+
+389
+00:39:54,120 --> 00:40:01,160
+Abortion لإنها غير يعني متوافقة مع الحياة بس ممكن
+
+390
+00:40:01,160 --> 00:40:05,660
+يوصل إنه طفل يولد فيها بس بطولش بعدها يعني
+
+391
+00:40:05,660 --> 00:40:10,840
+«Trisomy 21» راح ناخد عنه بعدين اللي هو Down
+
+392
+00:40:10,840 --> 00:40:16,390
+Syndromeوفيه ممكن Other Types of Trisomy فيه الـ…
+
+393
+00:40:16,390 --> 00:40:20,790
+الـAnomalies بالـX والـY كرمزومز فيه أشكال، أنواع،
+
+394
+00:40:20,790 --> 00:40:24,750
+كده وفيه الـUnbalanced والـBalanced Rearrangements
+
+395
+00:40:24,750 --> 00:40:31,010
+فالسة اللي قاعدة بتسأل عنه الدكتورة والأنواع
+
+396
+00:40:31,010 --> 00:40:35,930
+هنا شرّينها بس في أنه يعني تذكروا أنه فيه Balance
+
+397
+00:40:35,930 --> 00:40:40,220
+وفيه Unbalanced Rearrangementكل ما كانت Unbalanced
+
+398
+00:40:40,220 --> 00:40:46,240
+راح يكون الوضع أسوأ، ماشي؟ يعني هنا هاي Balanced
+
+399
+00:40:46,240 --> 00:40:54,960
+تقريبًا في مجال 16 حالة كانت أنه Balance يعني هاي
+
+400
+00:40:54,960 --> 00:41:00,580
+الحمل هذا كمل عند الولادة، يعني مش الحال أما لما
+
+401
+00:41:00,580 --> 00:41:06,800
+يكون Unbalanced، الوضع بيكون بالعكسبحيث أنه يعني
+
+402
+00:41:06,800 --> 00:41:11,780
+ما بعيشي كثير والـBalance لسه كمان هذا ما بنقول
+
+403
+00:41:11,780 --> 00:41:16,140
+هذه الصفة الوراثية بعدين لأنه صحيح Balance
+
+404
+00:41:16,140 --> 00:41:20,460
+Rearrangement في هذا الإنسان هو طبيعي كمية الـDNA
+
+405
+00:41:20,460 --> 00:41:27,960
+عنده طبيعية بس لما نيجي يحاول يعمل خلايا للتكاتر
+
+406
+00:41:27,960 --> 00:41:35,740
+راح يكون فيها مشاكل أكترفبعتبر هذه جدول من أهم
+
+407
+00:41:35,740 --> 00:41:41,080
+الجداول لنسب في إحدى الدراسات واللي هو الرجع ممكن
+
+408
+00:41:41,080 --> 00:41:46,680
+واحد يرجعله ممكن في مجتمع آخر ذا في أرقام مختلفة
+
+409
+00:41:46,680 --> 00:41:50,820
+نوعًا ما ولكن يعني أنا أظن إنه هيك تقريبًا في
+
+410
+00:41:50,820 --> 00:41:55,660
+العالم كله بهذا الشكل وعدد الولادات بشكل طبيعي
+
+411
+00:41:55,660 --> 00:41:59,280
+منطقتنا العربية الإسلامية الزواج الأقارب
+
+412
+00:42:02,020 --> 00:42:06,520
+كان فيه غرافية معينة يعني فيه فرق بين البيض والسود
+
+413
+00:42:06,520 --> 00:42:11,540
+والسخر والأجناس
+
+414
+00:42:11,540 --> 00:42:18,280
+المختلفة فيها سلة فيها
+
+415
+00:42:18,280 --> 00:42:26,100
+سلة إحنا هيك خلصنا يعني أنا النقطة اللي بدنا
+
+416
+00:42:26,100 --> 00:42:32,880
+نذكرهااللي هي يعني المبدأ الأساسي أنا باعتبره اللي
+
+417
+00:42:32,880 --> 00:42:43,700
+الواحد يكون يكون من تباهيله اللي هو قضية إنه أنا
+
+418
+00:42:43,700 --> 00:42:51,780
+حتى إذا شكيت في عيب معين ومشكلة معينة يجب أن يكون
+
+419
+00:42:51,780 --> 00:42:58,000
+عندي الأداء المناسبة لدراسة هذا الشيءحطينا مثال
+
+420
+00:42:58,000 --> 00:43:05,760
+الـ الـ خلينا نسألها سؤال لما حطينا مثال قبل شوية
+
+421
+00:43:05,760 --> 00:43:14,700
+عن اللي هو اللي لما عملوا دراسة عن الـ Down
+
+422
+00:43:14,700 --> 00:43:20,020
+Syndrome اللي هي هذه شو الـ Test اللي ما حطهوش حتى
+
+423
+00:43:20,020 --> 00:43:24,620
+يقرأوا هذا الموضوع؟ من يعني
+
+424
+00:43:25,930 --> 00:43:31,770
+الشيء اللي هو فعلاً منطقي وما حطوه ضمن هذه الدراسة
+
+425
+00:43:31,770 --> 00:43:35,090
+يعني
+
+426
+00:43:35,090 --> 00:43:40,050
+هنا حطيه الـ Karyotype وحطيه أنواع من الأشياء
+
+427
+00:43:40,050 --> 00:43:44,210
+الوسط اللي هو الـMicroarray الـBinding ما Binding
+
+428
+00:43:44,210 --> 00:43:47,350
+مش جايبين سيرتها بس واضحة الأمور يعني لأن
+
+429
+00:43:47,350 --> 00:43:54,070
+الـChromosome كبير وواضح الفكرة يعني في حدا بده
+
+430
+00:43:54,070 --> 00:43:57,890
+يجاوبدكتورة أسماء بتحكي حكات قبل ما تتكلم أنت حكت
+
+431
+00:43:57,890 --> 00:44:04,010
+الـ Binding لأ الـ Binding هنا ماشي بس إيش ال ..
+
+432
+00:44:04,010 --> 00:44:08,930
+إيش الكبير أو اللي كانت تقنية أهم واحد من أهم
+
+433
+00:44:08,930 --> 00:44:11,890
+الأشياء الـ .. الدكتورة السياسية بتقول الـ
+
+434
+00:44:11,890 --> 00:44:16,770
+Electrophoresis ممكن؟ لأ مش الـ Electrophoresis
+
+435
+00:44:16,770 --> 00:44:20,910
+الـ Electrophoresis هدولة اللي .. اللي تحتها الـ T
+
+436
+00:44:20,910 --> 00:44:26,030
+ثانثة تنتينماشي، فيهم الـ Electrophoresis حتى تشوف
+
+437
+00:44:26,030 --> 00:44:31,450
+الواحد الكمية تبعته الواضح أنه أدنى وأدقشي الـ
+
+438
+00:44:31,450 --> 00:44:33,590
+Whole Sequencing الدكتورة بسمعك الـ whole genome
+
+439
+00:44:33,590 --> 00:44:38,530
+sequencing دكتورة بسمعك ليش تقعد تقرأ كل حرف بحرف
+
+440
+00:44:38,530 --> 00:44:44,920
+وما أنت شايف فتعة كبيرة زايدة، ماشي؟فإنك هنا تطلب
+
+441
+00:44:44,920 --> 00:44:49,260
+Whole-Genome Sequencing وانت بتقول دهنك إنه بفكر
+
+442
+00:44:49,260 --> 00:44:53,680
+في Down Syndrome مش منطقي لإنك بتضيع المصارع
+
+443
+00:44:53,680 --> 00:44:58,760
+الفاضية بتعمل فحص مش ضروري فاهم عليك؟ لما بدك تشك
+
+444
+00:44:58,760 --> 00:45:02,980
+في حالة بدك تدرس جانب معين بدك تستخدم الأداء
+
+445
+00:45:02,980 --> 00:45:07,740
+المناسب خاينة الطبيعة، ماشي؟
+
+446
+00:45:07,740 --> 00:45:16,160
+فالآن اليوم راح نتكلمالـChromosomal Genomic Basis
+
+447
+00:45:16,160 --> 00:45:20,540
+of Disorders of the Autosomes and Sex Chromosomes
+
+448
+00:45:20,540 --> 00:45:25,580
+يعني نرجع مرة تانية نرجع
+
+449
+00:45:25,580 --> 00:45:30,080
+مرة تانية لأشياء
+
+450
+00:45:30,080 --> 00:45:36,060
+القريبة اللي أخذناها منها يعني اللي هو من الـslide
+
+451
+00:45:36,060 --> 00:45:40,200
+الأخير الـ
+
+452
+00:45:42,020 --> 00:45:50,960
+النقطة الأولى، ماشي، ليش؟ يعني وين الإشكالية حتى
+
+453
+00:45:50,960 --> 00:45:55,640
+تحدث مثل هذه الأشياء؟ إن يصير عندي خلل في عدد
+
+454
+00:45:55,640 --> 00:46:04,940
+الكرموزومات أو خلل في وجودها وكذا أهم واحد أنا
+
+455
+00:46:04,940 --> 00:46:08,380
+باعتبر، يعني على الأقل هيك للواحد حتى يفهمها اللي
+
+456
+00:46:08,380 --> 00:46:12,670
+هي Abnormal Chromosomal Segregationيعني الـ Non
+
+457
+00:46:12,670 --> 00:46:21,170
+-Disjunction يعني الفكرة هنا إنه أنا في ظاهرة
+
+458
+00:46:21,170 --> 00:46:26,610
+انقسام الخلية حكينا على إنه بالـ Metaphase لازم
+
+459
+00:46:26,610 --> 00:46:34,570
+بالنصف، في المستوى المنصف للخلية تيجي الكرمозومات
+
+460
+00:46:34,570 --> 00:46:42,230
+كلها بتصف جن بعضكل اتنين تقبل بعض مظبوطات وفيه
+
+461
+00:46:42,230 --> 00:46:48,950
+Central Zones على الطرفين وفيه قيوط الـ Spindle
+
+462
+00:46:48,950 --> 00:46:57,370
+Fibers اللي هي زي العضلات بتجذب القطعتين هدولة
+
+463
+00:46:57,370 --> 00:47:06,210
+للطرفين، ماشي؟ يعني هو اللي بتكلموا عنه إذا لسبب
+
+464
+00:47:06,210 --> 00:47:14,440
+ماكان عدم انفصال نظيف، كامل، سليم بين الـTwo
+
+465
+00:47:14,440 --> 00:47:18,740
+copies راح يصير عندي ما يسمونه «non-disjunction»
+
+466
+00:47:18,740 --> 00:47:24,340
+يعني إنه ما انفصلوش عن بعض بشكل سليم راح يكون عندي
+
+467
+00:47:24,340 --> 00:47:29,360
+نتيجة هذا الأمر يا إما الإثنين كلهم يروحوا على
+
+468
+00:47:29,360 --> 00:47:33,180
+الجهة واحدة وبالتالي الجهة الثانية، يعني الـTwo
+
+469
+00:47:33,180 --> 00:47:36,810
+copies كلهم يروحوا الجهة واحدةوالجهة التانية ما
+
+470
+00:47:36,810 --> 00:47:40,570
+راح يروحلها إشي من هذا الـ Search من الـ
+
+471
+00:47:40,570 --> 00:47:47,270
+Chromosomes أو إن أحيانًا أنه يعني واحد ونص يروح
+
+472
+00:47:47,270 --> 00:47:55,350
+هذه الجهة ونص يروح هناك، ماشي نتيجة هذا الأمر يعني
+
+473
+00:47:55,350 --> 00:48:04,170
+راح يكون Unemployed يعني تغير في عدد النساءماشي،
+
+474
+00:48:04,170 --> 00:48:07,830
+زي الـDown Syndrome الـKleinfilter وReverent
+
+475
+00:48:07,830 --> 00:48:14,210
+Dysentery وأشياء يعني من الأمثلة على الأمراض إنه
+
+476
+00:48:14,210 --> 00:48:20,090
+تكون عندي يا إما زيادة يا إما نقصة Recurrent
+
+477
+00:48:20,090 --> 00:48:24,290
+chromosomal syndromes Dyadic chromosomal anomalies
+
+478
+00:48:24,290 --> 00:48:27,790
+Unbalanced familial anomalies Abnormalities
+
+479
+00:48:27,790 --> 00:48:32,390
+Syndromes Endowing Genetic Genomic Imprinting
+
+480
+00:48:32,810 --> 00:48:43,070
+الباقية بدّيش يعني يعني بدّيش مش مهم كتير أحفظ
+
+481
+00:48:43,070 --> 00:48:48,630
+وأفهم ليش بتصير وكيف بتصير وكده يعني حكينا قبل
+
+482
+00:48:48,630 --> 00:48:54,030
+شوية عن إنه إذا في balance translocation موجود في
+
+483
+00:48:54,030 --> 00:49:00,460
+شخص معين هذا رح يعمل مشكلة ويكون في الـالـ
+
+484
+00:49:00,460 --> 00:49:05,640
+Progeny، الذرية تبع هذا الإنسان نفسه هو ممكن ما
+
+485
+00:49:05,640 --> 00:49:09,800
+يبين عليه أي مرضه، مايكون فيه مشكلة فحسب طبيعة
+
+486
+00:49:09,800 --> 00:49:15,240
+الخلل، طبيعة الانتقال، طبيعة الارتباط البعض بنتج
+
+487
+00:49:15,240 --> 00:49:21,560
+عنه، راح نحكي على أمراض ومشاكل وأنواع من المشاكل
+
+488
+00:49:21,560 --> 00:49:27,480
+التالية بس بظل يعني أنا أظن الأسهل وفينا يعني في
+
+489
+00:49:27,480 --> 00:49:32,810
+أمراض كثيرةمشهورة أو واحدة الميزة إذا شاف مريض مثل
+
+490
+00:49:32,810 --> 00:49:35,910
+هذا النوع اللي هي الـNon-distinction اللي هي
+
+491
+00:49:35,910 --> 00:49:39,870
+الـAbnormal Chromosomal Segregation هذه
+
+492
+00:49:39,870 --> 00:49:50,710
+الـMechanisms واللي نتكلم عنه هي النوعية الأكبر أو
+
+493
+00:49:50,710 --> 00:49:54,190
+نوعية قطع الكرموزومات الأكبر اللي هي
+
+494
+00:49:54,190 --> 00:50:02,280
+الـChromosomal Anomaliesبذكر مرة ثانية تذكروا إنه
+
+495
+00:50:02,280 --> 00:50:06,920
+إحنا في تعاملنا مع الأمراض الوراثية لازم هيك أحطها
+
+496
+00:50:06,920 --> 00:50:11,900
+بين ثلاث أنواع يا إما إشي في الـ Chromosome كله
+
+497
+00:50:11,900 --> 00:50:17,980
+وهي اللي راح نتكلم عنه يا إما Mendelian اللي هي
+
+498
+00:50:17,980 --> 00:50:22,140
+Single Nucleotide Single Gene Single Protein
+
+499
+00:50:22,140 --> 00:50:30,400
+متخصصةإلى قواعد وصول ومبادئ وفي المجموعة الثالثة
+
+500
+00:50:30,400 --> 00:50:34,780
+اللي هي اللي بيسموها Polygenic اللي هي بتكون أكتر
+
+501
+00:50:34,780 --> 00:50:38,660
+من جين بيستخدمها وهنا اللي نحن نتكلم عنه
+
+502
+00:50:38,660 --> 00:50:44,820
+Epigenetic Control الـGenetic Imprinting المشعرات
+
+503
+00:50:44,820 --> 00:50:50,140
+الـDNA Methylation الـHistone Methylation الـMicro
+
+504
+00:50:50,140 --> 00:50:55,040
+RNA Anomalies أو Changesفيه لها Mechanisms كثيرة
+
+505
+00:50:55,040 --> 00:51:01,520
+تتدخّل بعدين تشترك إنه الخلل أو المختلاف تكون فيه
+
+506
+00:51:01,520 --> 00:51:07,260
+عدد كبير من الجينات بطريقة مختلفة تتحكم في وظيفة
+
+507
+00:51:07,260 --> 00:51:11,780
+الـChromosome أو وظيفة الـDNA أو وظيفة البروتينز
+
+508
+00:51:11,780 --> 00:51:15,160
+فاحنا اليوم والآن على الـChromosome الـAnonymous
+
+509
+00:51:15,160 --> 00:51:18,860
+المجموعة
+
+510
+00:51:18,860 --> 00:51:25,030
+الأولىاللي هو يعني دايماً مش غلط الواحد يتذكر اللي
+
+511
+00:51:25,030 --> 00:51:33,330
+هم الـDance اللي هم المهم الواحد يعرف فضية اللي هي
+
+512
+00:51:33,330 --> 00:51:38,790
+الـCommon things are common أشياء شائعة شائعة
+
+513
+00:51:38,790 --> 00:51:43,150
+وبالتالي يعني هو اللي لازم يقدر يميزها بسرعة
+
+514
+00:51:43,150 --> 00:51:50,520
+وينتبع عليها ويتعامل معاهاالـ Trisomy السانيات
+
+515
+00:51:50,520 --> 00:51:57,120
+الأنواع التانية 18 و13 اللي هي مثلًا Cryotic K-Sac
+
+516
+00:51:57,120 --> 00:52:02,000
+أو الـ Edwards Syndrome أضل واحد ثاني إلى ثاني
+
+517
+00:52:02,000 --> 00:52:10,350
+ثاني، لأ الوضع أسوأ بكتيرماشي، وكلهم بيعيشوش،
+
+518
+00:52:10,350 --> 00:52:14,750
+بيموتوا بسرعة، ولادات يعني بعد الولادة بسرعة وفيه
+
+519
+00:52:14,750 --> 00:52:17,770
+severe mental retardation، severe heart
+
+520
+00:52:17,770 --> 00:52:25,310
+malformation كذا، بتلاقي فيه مشاكل كبيرة الـ Down
+
+521
+00:52:25,310 --> 00:52:30,770
+Syndrome مشهور ومعروف لما كنت طالب كنا هيك نتحدى
+
+522
+00:52:30,770 --> 00:52:36,790
+بعضحتى الواحد يذكرها كنا نقول فيه 30 character
+
+523
+00:52:36,790 --> 00:52:42,690
+موجودة في الـ Down Syndrome فنتبهوا هنا Hypotonia
+
+524
+00:52:42,690 --> 00:52:47,670
+يعني الشدة
+
+525
+00:52:47,670 --> 00:52:55,130
+العضلات، قوة العضلات، فيها رخاوة يعني، فـHypotonia
+
+526
+00:52:55,130 --> 00:53:01,290
+Short Stature، الطول القصير، Loose Skinon the
+
+527
+00:53:01,290 --> 00:53:07,610
+nape، اللي هو يعني على ال .. يعني في أسفل الظهر أو
+
+528
+00:53:07,610 --> 00:53:12,410
+في أسفل الرقبة الـ Palmer crease، احنا الأيديان
+
+529
+00:53:12,410 --> 00:53:16,130
+الواحدة دي كده بتطلع عليها فيه الفنتان اللي تشوفه
+
+530
+00:53:16,130 --> 00:53:20,350
+واحد عنده Down Syndrome مثلها كخط واحد Palmer
+
+531
+00:53:20,350 --> 00:53:26,140
+crease وclinodectin فيه خلل في الأصابعالـ Flat
+
+532
+00:53:26,140 --> 00:53:36,020
+Octopus يعني المؤخرة الرأس مش مستديرة هيك مسطحة
+
+533
+00:53:36,020 --> 00:53:40,960
+الـ Picantal Folds اللي هي كما بيقولوا منغولية
+
+534
+00:53:40,960 --> 00:53:46,240
+يعني شبيهة بعيون المغولة والصينيين وGokul اللي هي
+
+535
+00:53:46,240 --> 00:53:52,550
+حقيقة في الـmedial aspect of the eyeبتلاقي في الـ…
+
+536
+00:53:52,550 --> 00:53:58,370
+في الـ… يعني fold بطريقة معينة هي اللي بتعطي
+
+537
+00:53:58,370 --> 00:54:03,570
+العيون زي الصينيين يعني الـBrush field spots حاطين
+
+538
+00:54:03,570 --> 00:54:08,150
+صورة لها في moderate to mild أحيانًا severe
+
+539
+00:54:08,150 --> 00:54:13,050
+intellectual disability التخلف عقليcongenital
+
+540
+00:54:13,050 --> 00:54:18,470
+heart diseases «ديودنال أدريزيا» يعني اختلالات
+
+541
+00:54:18,470 --> 00:54:26,870
+القلب التركيبية أو المشاكل للقلب تسكيرة الأتناشر
+
+542
+00:54:26,870 --> 00:54:33,610
+احتمالية أكبر للسرطانات احتمالية أكبر للتخلف
+
+543
+00:54:33,610 --> 00:54:41,850
+العقلي الآن باستراحة يعني ميزة الـاللي عندهم Down
+
+544
+00:54:41,850 --> 00:54:48,810
+Syndrome حقيقةً، يعني تذكر دائماً عنهم إنهم عندهم
+
+545
+00:54:48,810 --> 00:54:55,230
+pleasant personality يعني شخصيتهم لطيطة، حبابين،
+
+546
+00:54:55,230 --> 00:55:02,910
+بنحبهم، حلوين، تعاملهم يعني حلو يعني والـLife
+
+547
+00:55:02,910 --> 00:55:10,750
+expectancy 555 يعني هذه باعتبر أنا دائماًإن الواحد
+
+548
+00:55:10,750 --> 00:55:17,290
+يتذكر مثل هذه الحالة هي موجودة ومتواجدة أو تقريبًا
+
+549
+00:55:17,290 --> 00:55:25,670
+واحد في 850 ألف حالة يعني تقريبًا أقل من واحد في
+
+550
+00:55:25,670 --> 00:55:30,650
+الألف أكتر شوية من واحد في الألف واحد في 850 بتوقع
+
+551
+00:55:30,650 --> 00:55:36,070
+يكون عنده Down Syndrome فيعني
+
+552
+00:55:36,070 --> 00:55:41,210
+أدولة جزء من المجتمعبيدوني واحد يحن عليهم و .. بس
+
+553
+00:55:41,210 --> 00:55:44,750
+أنا بظن يعني من الأجمل الأشياء أنهم لطيفين يعني
+
+554
+00:55:44,750 --> 00:55:49,350
+آه، في أسئلة؟
+
+555
+00:55:49,350 --> 00:55:57,530
+فإذا في حد عنده سؤال، يسأل الملاحظة الأهم أو مهمة
+
+556
+00:55:57,530 --> 00:56:04,330
+كثير فضية أنه الـ Down Syndrome أحيانًا كثيرة
+
+557
+00:56:04,330 --> 00:56:05,910
+مرتبط بعمر الأمة
+
+558
+00:56:08,570 --> 00:56:14,390
+إذا بالذات الأم عمرها أكتر من الأربعين سنة نسبة
+
+559
+00:56:14,390 --> 00:56:19,850
+حدوث الـDownward Neuron ترتفع بنسبة عالية جداً
+
+560
+00:56:19,850 --> 00:56:24,810
+يعني هنا الطريقتين
+
+561
+00:56:24,810 --> 00:56:30,350
+للدراسة في البدل الأمنيوسي أو اللي هو أخذ سائل
+
+562
+00:56:30,350 --> 00:56:35,030
+حواليه من الجنين أو الإنتظار الميراثي يعني هذه
+
+563
+00:56:35,030 --> 00:56:39,630
+طريقة من الدراسات للأسف في دول تانيةباعتبره إنه
+
+564
+00:56:39,630 --> 00:56:47,510
+فحص للـ DNA أو لقى مرض معين في ذات الحمل إنه
+
+565
+00:56:47,510 --> 00:56:54,270
+بيعرضوا الإجهاض حتى ما يطلع الطفل عنده صابة بأساس
+
+566
+00:56:54,270 --> 00:56:57,730
+باعتبره إنه في نهاية جوانب أخلاقية في الطب
+
+567
+00:56:57,730 --> 00:57:04,030
+وأخلاقية في التعامل مع الحياة وكذا لأن احنا
+
+568
+00:57:04,030 --> 00:57:08,390
+تقريبًا يعني في كلام على إنه قبلنفوخ، يعني ذاك
+
+569
+00:57:08,390 --> 00:57:13,390
+الروح اللي هو تقريبًا 120 يوم يعني فيه شوية خلاف
+
+570
+00:57:13,390 --> 00:57:17,650
+بين الفقهاء والعلماء ممكن الواحد يعرض الإجهاض
+
+571
+00:57:17,650 --> 00:57:24,390
+وممكن يعني بما أنه لسه مش كائن
+
+572
+00:57:24,390 --> 00:57:29,990
+أو مش إنسان مكتمل يعني فالفكرة يعني، بس النقطة
+
+573
+00:57:29,990 --> 00:57:37,000
+الأساسية أنه إذا كبر عمره الأم، نسبةالـ Down
+
+574
+00:57:37,000 --> 00:57:42,600
+Syndrome تكبر كثير ماشي وخصوصًا فوق سن الأربعين
+
+575
+00:57:42,600 --> 00:57:49,520
+يعني هو نقع تكون كبير كثير عادى، فهذه ناحية ناحية
+
+576
+00:57:49,520 --> 00:57:55,780
+ثانية يعني من الأشياء اللي الواحد بده ينتبهلها أن
+
+577
+00:57:55,780 --> 00:58:00,920
+أحيانًا الـ Trisomy 21 مافيكونش في كل الخلايا،
+
+578
+00:58:00,920 --> 00:58:05,460
+تكون في نسب من الخلايا والمقصود أنهالـ Non
+
+579
+00:58:05,460 --> 00:58:12,180
+-disjunction هذا اللي صار يعني مش على مستوى الـ
+
+580
+00:58:12,180 --> 00:58:16,860
+Egg و الـ Sperm بحيث إنه واحد منهم بيكون فيه
+
+581
+00:58:16,860 --> 00:58:21,120
+المشكلة لو بالـ Egg و الـ Sperm الأصليات كل
+
+582
+00:58:21,120 --> 00:58:24,720
+الخلايا اللي راح تطلع راح تكون فيها مشاكل بس لو
+
+583
+00:58:24,720 --> 00:58:28,660
+صار Non-disjunction بعدين يعني بعد ما صارت
+
+584
+00:58:28,660 --> 00:58:34,500
+Fertilized Egg وانقسمت مثلا مرتين، تلاتةفصار عندي
+
+585
+00:58:34,500 --> 00:58:39,140
+مثلًا 16 خلية واحدة منهم هي اللي صار فيها Non
+
+586
+00:58:39,140 --> 00:58:44,000
+-disjunction في حتة إنه صارت فيها Trisomy 21 في
+
+587
+00:58:44,000 --> 00:58:48,460
+واحدة منهم في حتة إنه بنتج عن هذا الأمر إنه راح
+
+588
+00:58:48,460 --> 00:58:55,120
+يكون إنه نسبة يعني ربع الخلايا تلت الخلايا 60% من
+
+589
+00:58:55,120 --> 00:58:59,960
+الخلايا اللي فيها الخلل والبقية طبيعية في تفاوت،
+
+590
+00:58:59,960 --> 00:59:09,760
+يعني في درجاتفهي طبيعة مهمة هنا الـ Rough Spots
+
+591
+00:59:09,760 --> 00:59:13,600
+الـ Brush Field Spots هنا حاطين كيف شكل العين يعني
+
+592
+00:59:13,600 --> 00:59:17,840
+فاهرة معينة وهي الـ Epicanthic Fold اللي هي للجوا
+
+593
+00:59:17,840 --> 00:59:25,200
+و Big Tongue و Pleasant Personality ويعني هاي اللي
+
+594
+00:59:25,200 --> 00:59:31,370
+هو Down Syndrome من أشياء الأمراض الكرمزوميةاللي
+
+595
+00:59:31,370 --> 00:59:37,430
+هي في المجتمع الـ
+
+596
+00:59:37,430 --> 00:59:48,290
+في هناك يعني أحيانًا حتى لو أنا مش كعدد ك band
+
+597
+00:59:48,290 --> 00:59:51,810
+وعدد ممكن ألاقي في
+
+598
+00:59:56,860 --> 01:00:04,460
+يعني أحيانًا مظهريًا بكون إنسان شكله لما نعمله
+
+599
+01:00:04,460 --> 01:00:09,540
+Carrier-type لما أدققتش كثير ولكن بالأول إنه بس في
+
+600
+01:00:09,540 --> 01:00:17,120
+نسختين من الـChromosome 21 فبظن إن التشفيذ غلط أو
+
+601
+01:00:17,120 --> 01:00:24,080
+بقول إنه فيه مشكلة بكون إنه الـChromosome 21 كما
+
+602
+01:00:24,080 --> 01:00:30,060
+هو في الصورة هذهراكب نسخة منه على كروموزوم 14 كبير
+
+603
+01:00:30,060 --> 01:00:37,820
+كروموزوم 14 وبالتالي أحيانًا الـ… الـ… يعني هنا
+
+604
+01:00:37,820 --> 01:00:41,940
+إحنا حاطين مثال إنه أنا المفروض بشكل طبيعي أكون
+
+605
+01:00:41,940 --> 01:00:48,480
+عند كروموزوم 14 وكروموزوم 21 منفصلات بهذا الشكل
+
+606
+01:00:48,480 --> 01:00:55,160
+إذا في عندي Balance Translocation بهذا الشكل إنه
+
+607
+01:00:55,460 --> 01:00:59,060
+الـ Chromosome 21 اللي هو أنه أصغر واحد ومطرد هيكي
+
+608
+01:00:59,060 --> 01:01:03,800
+وصغير لذب كله بالغلط مع Chromosome 14 وظلوا
+
+609
+01:01:03,800 --> 01:01:10,120
+موجودين هناك فإذا إنسان خلايا بهذا الشكل برضه هذا
+
+610
+01:01:10,120 --> 01:01:15,700
+ماعنديهوش مشكلة إذا كانت بشكل مختلف بهذه الأشياء
+
+611
+01:01:15,700 --> 01:01:20,360
+بتكون الأمور Unbalanced وبتروح تكون فيها مشاكل
+
+612
+01:01:20,360 --> 01:01:27,290
+مختلفة كبيرةهنا راح يكون down لأنه فيه زيادة طبعاً
+
+613
+01:01:27,290 --> 01:01:31,310
+هاي one copy وفيه copies تانية زيها فبنتج عن هذا
+
+614
+01:01:31,310 --> 01:01:35,210
+الأمر الثاني اللي نفترضها راح تكون طبيعية راح يكون
+
+615
+01:01:35,210 --> 01:01:40,570
+أنه عندي ثلاثة أو هنا فيه فقد تام لل 21 هنا في
+
+616
+01:01:40,570 --> 01:01:47,460
+عندي ثلاثة copy من ال chromosome 14 حتىهنا عندي
+
+617
+01:01:47,460 --> 01:01:51,980
+نصفة واحدة بس يعني كل هدولة راح يسببوا إشكالات
+
+618
+01:01:51,980 --> 01:02:00,080
+وأمراض ويكون مشاكل اللي
+
+619
+01:02:00,080 --> 01:02:09,580
+لان النقطة الأولى اللي ذكرناها عن أمراض اليوم أو
+
+620
+01:02:09,580 --> 01:02:16,000
+حالات اليوم أنه بنحكي عن الـ Chromosome فحكينا عن
+
+621
+01:02:16,000 --> 01:02:21,300
+الـ Autosomal Chromosomes وبالذات Chromosome 21
+
+622
+01:02:21,300 --> 01:02:27,740
+وخلّينا هاي شو اسمه، هاي اللي نذكرها راح ناخد بعد
+
+623
+01:02:27,740 --> 01:02:31,980
+شوية على الـ Six Chromosomes وشو بيصير بيهم فرح
+
+624
+01:02:31,980 --> 01:02:37,320
+نرجع لموضوع كـ Chromosome كامل بعد شوية الآن فيه
+
+625
+01:02:37,320 --> 01:02:45,880
+ظواهر وأمراض نتيجة يعني قطعة مشالـ Chromosome كامل
+
+626
+01:02:45,880 --> 01:02:53,000
+فمن الأشياء اللي أنا يعني بصراحة الـ Down Syndrome
+
+627
+01:02:53,000 --> 01:02:59,940
+شوفتالأنواع التانية للـ Autosome الـ 313، الـ 318،
+
+628
+01:02:59,940 --> 01:03:04,700
+الـ 360، ما عمري شوفت ويمكن الواحد بيكون
+
+629
+01:03:04,700 --> 01:03:11,320
+Neonatologist يشوف الـ Abortion ويعمل، يشوف شو
+
+630
+01:03:11,320 --> 01:03:18,920
+بيصير يعني في الموليد الجددالحديثي الولادة إذا ما
+
+631
+01:03:18,920 --> 01:03:23,420
+كان الواحد هذا تخصصه يمكن احتمال نادر أن يشوف
+
+632
+01:03:23,420 --> 01:03:29,840
+الأمراض اللي بنحكي عنها ماشي ال أنا بالنسبة لي
+
+633
+01:03:29,840 --> 01:03:35,740
+كمناعة وحساسية بهمني حالة اسمها Die George
+
+634
+01:03:35,740 --> 01:03:44,180
+Syndrome نخبركم عنها ويعني من كل هالالأمراض
+
+635
+01:03:44,180 --> 01:03:50,000
+والمشاكل وكذا أنا ماشوفتش الأنواع التانية و… بس
+
+636
+01:03:50,000 --> 01:03:57,460
+خلّينا عشان يعني يعني أنا بقول لوحدي لما يكون إن
+
+637
+01:03:57,460 --> 01:04:01,560
+شاء الله عنده المراجع وعنده ممكنية التواصل معاها
+
+638
+01:04:01,560 --> 01:04:06,880
+بالـ PubMed ولا الـ Online Mendelian Resource
+
+639
+01:04:06,880 --> 01:04:12,920
+لأسماء الأمراض الوراثية وكدهبكون إن شاء الله أموره
+
+640
+01:04:12,920 --> 01:04:17,860
+كويسة الـ Diehard Syndrome من أيام ما كنت طالب
+
+641
+01:04:17,860 --> 01:04:25,140
+يدرسوني إياه و هو من أحد أمراض مقصان المناعة و فيه
+
+642
+01:04:25,140 --> 01:04:31,780
+له مشكاك الكثير و يعني كنت محبوب لقبل أربع سنين
+
+643
+01:04:31,780 --> 01:04:36,740
+يعني بعد ما أجزت و شابل واحد لحظة أني شفت حالة
+
+644
+01:04:36,740 --> 01:04:43,610
+واحدة في حياتي هي شغلاتعبارة عن حالات نادرة
+
+645
+01:04:43,610 --> 01:04:53,010
+والواحد يعني بده يكون عنده قدرة على إنه يعني لما
+
+646
+01:04:53,010 --> 01:04:59,610
+نشوفها ويشك في إنها موجودة يعرف يطلب الفحص المناسب
+
+647
+01:04:59,610 --> 01:05:06,340
+حتى ألاقي هذه الشغلوأشوف أنه يعني أقدر أشخصها
+
+648
+01:05:06,340 --> 01:05:10,800
+ويكون عندي حتى فكرة شو الـ mechanism كان أنه صارت
+
+649
+01:05:10,800 --> 01:05:15,280
+وين الـ translocation وين الـ الـ كانت balanced،
+
+650
+01:05:15,280 --> 01:05:20,160
+unbalanced، شو صارت وكده الـ Dijard Syndrome،
+
+651
+01:05:20,160 --> 01:05:28,560
+ماشي، الآن احنا يعني we mapped it to chromosome 22
+
+652
+01:05:30,240 --> 01:05:36,900
+الـ «Q» اللي هو الـ «Long Arm» تبعته الـ «Band 11
+
+653
+01:05:36,900 --> 01:05:44,860
+.2» هو بتصير عملية «Deletion» يعني في إزالة لقطعة
+
+654
+01:05:44,860 --> 01:05:52,620
+صغيرة من الـ «DNA» يعني بالضبط كام «Gen»
+
+655
+01:05:52,620 --> 01:05:58,520
+موجود فيها بطيرًا عشان يستعطينا البرض هذا ما بعرف
+
+656
+01:05:58,520 --> 01:06:05,820
+100%فالـ Diehard Syndrome يعني إيه له قصص هيك
+
+657
+01:06:05,820 --> 01:06:12,760
+بعرفتها والواحد بيحكيها الـ Diehard Syndrome عبارة
+
+658
+01:06:12,760 --> 01:06:18,580
+عن لما يصير الـ deletion لهذا القطع من الـ DNA،
+
+659
+01:06:18,580 --> 01:06:24,680
+ماشي، بيصير عندي anomaly في الـ development تبعت
+
+660
+01:06:24,680 --> 01:06:28,650
+الـ third والfour pharyngeal pouchesفي الـ
+
+661
+01:06:28,650 --> 01:06:33,650
+Emperogenesis يعني إذا تتذكروا الـ Emperogenesis
+
+662
+01:06:33,650 --> 01:06:38,770
+اللي هي بالذات three to four pharyngeal pouches
+
+663
+01:06:38,770 --> 01:06:44,550
+بتكون في لحظة معينة زي ما إحنا بالقرآن الكريم نقول
+
+664
+01:06:44,550 --> 01:06:50,610
+إن الجنين على شكل المضغة المضغة يعني زي قطعة البن
+
+665
+01:06:50,610 --> 01:06:57,050
+على الكواكس شديتها ويكون عليها الـ pharyngeal
+
+666
+01:06:57,050 --> 01:07:01,820
+pouchesفبتطير أو بيصير خلل في الـ third والـ
+
+667
+01:07:01,820 --> 01:07:05,620
+fourth pharyngeal pouches أتأمل أنكم أخدتم الـ
+
+668
+01:07:05,620 --> 01:07:10,820
+embryology نتيجة هذا الخلل بيصير عندي ثلاث مظاهر
+
+669
+01:07:10,820 --> 01:07:15,820
+رئيسية الـ third والـ fourth pharyngeal pouches
+
+670
+01:07:15,820 --> 01:07:23,000
+بيكون فيهملأن هم راح يعطي الـ Thymus أو الغد الـ
+
+671
+01:07:23,000 --> 01:07:29,900
+2T اللي هي تبعت المناعة اللي في الصدر المنطقة
+
+672
+01:07:29,900 --> 01:07:34,640
+الأمامية من الصدر فبصير عندي Absent Thymus والـ
+
+673
+01:07:34,640 --> 01:07:38,020
+Thymus ضرورية للـ Development للـ T-cells في
+
+674
+01:07:38,020 --> 01:07:44,280
+المناعة هي بتتعلم، هي تتكون، هي تتنشط الـ Thymus
+
+675
+01:07:44,280 --> 01:07:47,880
+فبصير عندي Absence of T-cells وبالتالي عندي Immune
+
+676
+01:07:47,880 --> 01:07:52,100
+Deficiencyبيصير عنده Immune Deficiency الوظيفة
+
+677
+01:07:52,100 --> 01:07:55,480
+الثانية للـthird والـfourth pharyngeal pouches إن
+
+678
+01:07:55,480 --> 01:07:59,780
+هي بتشترك في الـroot of the heart في الـmajor
+
+679
+01:07:59,780 --> 01:08:04,100
+blood vessels فالـmajor blood vessels الأورطة
+
+680
+01:08:04,100 --> 01:08:08,460
+والبلمونري آرتي والـtruncus arteriosus والأشياء
+
+681
+01:08:08,460 --> 01:08:12,920
+هذه بتصير فيها خلب فبيصير عندي congenital heart
+
+682
+01:08:12,920 --> 01:08:18,160
+disease بيصير عندي مرض قلب خلقي عيب خلقي في القلب
+
+683
+01:08:18,920 --> 01:08:22,020
+الشغل الثالث اللي بتكون نتيجة الـ «تيرد» والـ
+
+684
+01:08:22,020 --> 01:08:28,480
+«بورت» الـ «ترنجيال باوتش» اللي هم الـ الـ الـ الـ
+
+685
+01:08:28,480 --> 01:08:33,540
+Parathyroid glands والـ Parathyroid glands أهميتهم
+
+686
+01:08:33,540 --> 01:08:37,200
+بالتحكم في الـ «ميتابوليزم» تبع الـ «كالسيو» فبصير
+
+687
+01:08:37,200 --> 01:08:42,220
+عندي مشكلة «هيبوكالسينيا» و«تيتاني» بصير الجنين أو
+
+688
+01:08:42,220 --> 01:08:46,920
+الـ أو الجنين يعني الـ «نيو بورن» بصير عنده تشلجات
+
+689
+01:08:46,920 --> 01:08:51,020
+و«تيتاني»وفيكون نتيجة الـHypocalcemia بسبب
+
+690
+01:08:51,020 --> 01:08:57,780
+الـHypoparathyroidism فالـVelio
+
+691
+01:08:57,780 --> 01:09:01,880
+-below-cardiofacial syndrome أي الإسم التاني
+
+692
+01:09:01,880 --> 01:09:06,680
+للـDijord Syndrome يكون عندي مشاكل في القلب، مشاكل
+
+693
+01:09:06,680 --> 01:09:11,160
+في الـThymus وفي المناعة ومشاكل في الـCalcium وفي
+
+694
+01:09:11,160 --> 01:09:16,360
+الـMetabolism تبع الـHypoparathyroidism
+
+695
+01:09:17,070 --> 01:09:22,250
+النقطة الأخيرة فيهم اللي هي قضية إنه راح يكون
+
+696
+01:09:22,250 --> 01:09:28,630
+بيسموها «Dysmorphic Features» الحاطين هنا أظن صور
+
+697
+01:09:28,630 --> 01:09:32,250
+اللي
+
+698
+01:09:32,250 --> 01:09:38,210
+هم الـ «Trisomy 21» خلّيني أشوف، لأ مش حاطين
+
+699
+01:09:38,210 --> 01:09:41,870
+«Dijord Syndrome» بيبسوه، بيكون بيسموها «Loss of
+
+700
+01:09:41,870 --> 01:09:50,300
+ears»يعني الـ… الـ… لما الواحد يشوف الجنين الأصل
+
+701
+01:09:50,300 --> 01:09:54,180
+في الإنسان إذا الواحد انتبه على حاله إنه ديناي
+
+702
+01:09:54,180 --> 01:09:57,820
+بيكونوا على مستوى العين يعني إذا أخدت خط بين
+
+703
+01:09:57,820 --> 01:10:02,380
+الآنتين الدينان تقريباً هنا إذا دينان الواحد أنزل
+
+704
+01:10:02,380 --> 01:10:07,080
+من هذا الوضع يسموها «loss of ear» يكون «increased
+
+705
+01:10:07,080 --> 01:10:11,340
+philtrum» اللي هي المسافة بين الأمك والشفة العلية
+
+706
+01:10:11,880 --> 01:10:16,560
+اللي كونها شكلها «increase» فإنهم شكل مميز يعني
+
+707
+01:10:16,560 --> 01:10:24,000
+فهذا إيش اسمه «Digest Syndrome» فبقية الـ
+
+708
+01:10:24,000 --> 01:10:29,920
+«diseases» بدّيش يعني الفكرة فيها مراد كثيرة وهي
+
+709
+01:10:29,920 --> 01:10:36,100
+«list of examples» يعني هذولة نسبة أو يعني عدد
+
+710
+01:10:36,100 --> 01:10:42,400
+محدود من الأمثلةوإنه في عندي أمراض كثيرة أخرى
+
+711
+01:10:42,400 --> 01:10:48,580
+بيكون أنا المشكلة عندي هي segmental deletion أو
+
+712
+01:10:48,580 --> 01:10:53,560
+duplication يعني عبارة عن قطعة مش الـ…
+
+713
+01:10:53,560 --> 01:11:00,120
+الـChromosome كامل، ماشي؟ فهذه أشياء بتحدث وموجودة
+
+714
+01:11:00,120 --> 01:11:08,040
+في الطبيعة، موجودة في الحياةموجودة ومؤثرة والواحد
+
+715
+01:11:08,040 --> 01:11:15,160
+تطفت عنده حالة بده يحسن التنقيب والبحث عن من
+
+716
+01:11:15,160 --> 01:11:21,760
+المراجع العلمية المعتمدة الـ Online Databases زي
+
+717
+01:11:21,760 --> 01:11:27,190
+ما بقوله، قواعد البيانات على الـNetبحيث إنه يدخل
+
+718
+01:11:27,190 --> 01:11:31,630
+كل المعلومات اللي بعرفها كمظاهر ويحاول يلاقي منها
+
+719
+01:11:31,630 --> 01:11:39,170
+شو التشخيص أو وين العلة عشان يختار بعدين الـTest
+
+720
+01:11:39,170 --> 01:11:42,370
+المناسب حتى يثبت إن هذا الموضوع موجود
+
+721
+01:11:42,370 --> 01:11:46,910
+فالـRearrangement
+
+722
+01:11:46,910 --> 01:11:52,770
+لقضية اللي يصير Deletion أو Duplication أثنانهم
+
+723
+01:11:52,770 --> 01:11:58,920
+لنفس الـMechanism لما نكونعندي سواء إذا كامل، Non
+
+724
+01:11:58,920 --> 01:12:02,920
+-distinction يعني بتكون أثنين مع بعض بيروحوا هيك
+
+725
+01:12:02,920 --> 01:12:07,720
+أو صفر بيروح الجهة الثانية، بتكون كاملة بس أحياناً
+
+726
+01:12:07,720 --> 01:12:13,160
+بتكون على قطعة وبتكون إنه إشي بنتقل من محل لمحل
+
+727
+01:12:13,160 --> 01:12:18,220
+ثاني فبنتج عنه إنه في نسخة راح تكون Duplication
+
+728
+01:12:18,220 --> 01:12:23,440
+وفي نسخة تانية أو جهة تانية راح يكون فيه Deletion
+
+729
+01:12:23,440 --> 01:12:32,240
+فهي لنفس الـMechanismهنا برضه يعني هاي هون اللي
+
+730
+01:12:32,240 --> 01:12:37,460
+عملنا عن طريق الـ Karyotype على Binding دورت على
+
+731
+01:12:37,460 --> 01:12:45,080
+إشي معين ممكن أنا هنا الـ Fish كأسلوب أدور على
+
+732
+01:12:45,730 --> 01:12:53,610
+بطريقة معينة عليهم وبعدين في عندي اللي هو micro
+
+733
+01:12:53,610 --> 01:12:59,850
+arrays بتكون أنا ممكن أدور بطريقة معينة وبعدين
+
+734
+01:12:59,850 --> 01:13:10,590
+بروح أقراها ويعني بتكون عندي، شو اسمه؟ محاضرة أنا،
+
+735
+01:13:10,590 --> 01:13:11,610
+محاضرة، محاضرة
+
+736
+01:13:14,980 --> 01:13:23,480
+فأسف، يعني هذه الأليات المختلفة لمعرفة النوع
+
+737
+01:13:23,480 --> 01:13:30,080
+التاني من الـChromosome Anomalies يعني هنا
+
+738
+01:13:30,080 --> 01:13:36,060
+كـChromosome كامل، فيه عدد محدودكقطع من
+
+739
+01:13:36,060 --> 01:13:41,140
+الكرموزومات، فيه برضه نسبة موجودة، هناك أنفل عليها
+
+740
+01:13:41,140 --> 01:13:46,880
+دخلنا على قصة الـDijort Syndrome كمثال، مديش غيره،
+
+741
+01:13:46,880 --> 01:13:56,600
+بس الفكرة إنه بكون في عندي يعني مظاهر متعددة وانا
+
+742
+01:13:56,600 --> 01:14:00,060
+بإمكاني أدرسها بطرق مختلفة
+
+743
+01:14:03,080 --> 01:14:07,620
+في حاجة اسمها «Brother Willy Engelman Syndromes»
+
+744
+01:14:07,620 --> 01:14:12,700
+كانوا حاطين صورهم بهذا الشكل، ماشي، رخاوة في
+
+745
+01:14:12,700 --> 01:14:20,420
+العضلات، تخلف عقلي، أمراض، مشاكل ثانية، إذا الواحد
+
+746
+01:14:20,420 --> 01:14:27,520
+بدي ياخد خط الطب كـPediatrician، كـGeneticist أو
+
+747
+01:14:27,520 --> 01:14:30,340
+كذا، بدي يصير يعرف عنهم ويتعامل معهم
+
+748
+01:14:34,340 --> 01:14:38,860
+الآن الجانب الأخير من الأمراض الكرمزومية اللي هو
+
+749
+01:14:38,860 --> 01:14:43,220
+الـ Sex Chromosomes الـ Sex Chromosomes يعني ناحية
+
+750
+01:14:43,220 --> 01:14:52,960
+مهمة كثير ويعني بدها تكون نابع للواحد من فهم ضروري
+
+751
+01:14:52,960 --> 01:15:02,380
+للمبادئ تبعتها بالنسبة للـ Sex Development وتطور
+
+752
+01:15:02,380 --> 01:15:12,050
+الإنسان الجنسيبنلاقي أنا عندى بتكلم عن ثلاث
+
+753
+01:15:12,050 --> 01:15:20,710
+مستويات من المظاهر وأحياناً طبعاً في الغالب بتكون
+
+754
+01:15:20,710 --> 01:15:27,830
+بطرق معينة بس هناك طرق متعددة للاختلالات فالأصل
+
+755
+01:15:27,830 --> 01:15:33,850
+الإنسان الرجل الذكر بكون عنده X Y chromosome
+
+756
+01:15:35,940 --> 01:15:44,340
+التركيب للـ «جونات» أو العضاء التناثولية تبعته إنه
+
+757
+01:15:44,340 --> 01:15:51,480
+عنده خصي أو Testiclesماشي، وبالأخير تعطي مظاهر
+
+758
+01:15:51,480 --> 01:15:59,640
+اللي نرضقها بالدكورة يعني الصوت أجش الشعر في
+
+759
+01:15:59,640 --> 01:16:04,500
+اللحية وفي مناطق معينة في الجسم كمية العضلات في
+
+760
+01:16:04,500 --> 01:16:10,920
+جسمه أكبر الهرمونات في منصة جسمه تكون مختلفة هذه
+
+761
+01:16:10,920 --> 01:16:15,040
+اللي بيسميها مظاهر الدكورة أو الأنوثة الـ
+
+762
+01:16:15,040 --> 01:16:23,940
+Phenotypeالـ Phenotype هذا هو نتيجة أول شيء جزء
+
+763
+01:16:23,940 --> 01:16:28,840
+منه الكروموزومات وما ينتج عنها منه بروتينات وما
+
+764
+01:16:28,840 --> 01:16:35,520
+ينتج عنها منه تراكيب ثم بعد ذلك جوانب هرمونية
+
+765
+01:16:35,520 --> 01:16:41,980
+نتيجة الـ Gonads وبعد ذلك الصراحة الجوانب
+
+766
+01:16:41,980 --> 01:16:49,870
+المجتمعيةيعني الـ role-playing يعني المجتمع عادة
+
+767
+01:16:49,870 --> 01:16:56,750
+الطفل من صغره إذا كان ذكر بيصيروا يقولوا أنت زلمة
+
+768
+01:16:56,750 --> 01:17:01,570
+واش بتعيط زي البنات ولا بيصيروا ربوه على إنه يكون
+
+769
+01:17:01,570 --> 01:17:06,190
+خش إنه ما يشكيش وإنه كده وإنه كده كدا بتلاقي بواهر
+
+770
+01:17:06,190 --> 01:17:11,390
+حتى من ناحية المجتمع بتتدخل فيه شويه يعني مناسب
+
+771
+01:17:11,900 --> 01:17:17,960
+لأنه هذا رجل أو هي أنثى فبالمقابل
+
+772
+01:17:17,960 --> 01:17:23,060
+الـ Females في عندنا بيكون عندهم XX chromosomes
+
+773
+01:17:23,060 --> 01:17:30,740
+بتكون عندنا مبايض Ovaries وبعدين بيصير الشكل
+
+774
+01:17:30,740 --> 01:17:36,120
+المميز للـ Phenotype كـ Female تتدخل فيه أشياء
+
+775
+01:17:36,120 --> 01:17:40,060
+كتيرة الآن
+
+776
+01:17:40,470 --> 01:17:46,230
+الـ Y-Chromosome حقيقةً فيه عدد قليل من الجينات
+
+777
+01:17:46,230 --> 01:17:51,890
+حاطين هنا تفاصيل من أصغر الـChromosomes كمان زي
+
+778
+01:17:51,890 --> 01:17:57,070
+الـChromosome 21 قريب منه يعني في الحجم وبكون
+
+779
+01:17:57,070 --> 01:18:06,910
+مافيش فيه، إيش اسمه؟ مايكونش فيه يعني كبير عدد من
+
+780
+01:18:06,910 --> 01:18:12,010
+الـChromosomes اللي بتأثر علىأشياء محينة يعني،
+
+781
+01:18:12,010 --> 01:18:16,450
+ماشي، فياسلة؟
+
+782
+01:18:16,450 --> 01:18:19,650
+السلام
+
+783
+01:18:19,650 --> 01:18:23,250
+عليكم، فياسلة؟ تمام لحد الآن يا دكتور، تمام، مافي
+
+784
+01:18:23,250 --> 01:18:30,010
+سؤال يعني، طيب، الفهم لكيف تطور الدكور والإينات
+
+785
+01:18:30,590 --> 01:18:34,370
+وكيف ربنا حطم فينا هيك الأشياء وكيف ربنا خلقنا
+
+786
+01:18:34,370 --> 01:18:46,890
+صراحة فيه يعني أفضل تقويم ويعني كيف الإنسان بتخلق
+
+787
+01:18:46,890 --> 01:18:51,970
+حقيقة يعني عجبة من الله سبحانه وتعالى من الأشياء
+
+788
+01:18:51,970 --> 01:18:59,560
+اللي لازم تكونوا تتذكروها أولاً أنهفي الـ
+
+789
+01:18:59,560 --> 01:19:05,580
+Embryogenesis يعني في مرحلة تخلق الإنسان في مرحلة
+
+790
+01:19:05,580 --> 01:19:12,160
+الجنينية المبكرة ناشي الإنسان بيولد بالأول أو
+
+791
+01:19:12,160 --> 01:19:21,360
+بيتخلق بالأول وعنده تراكيب يعني ذكورة وأنوثة في
+
+792
+01:19:21,360 --> 01:19:28,560
+نفس الوقت ناشيفبقرا «ميزونفريك دكت» «ميزونفريك
+
+793
+01:19:28,560 --> 01:19:32,900
+دكت» «ميزونفريك
+
+794
+01:19:32,900 --> 01:19:38,400
+دكت» «ميزونفريك دكت» «ميزونفريك دكت» «ميزونفريك
+
+795
+01:19:38,400 --> 01:19:39,040
+دكت» «ميزونفريك دكت» «ميزونفريك دكت» «ميزونفريك
+
+796
+01:19:39,040 --> 01:19:39,520
+دكت» «ميزونفريك دكت» «ميزونفريك دكت» «ميزونفريك
+
+797
+01:19:39,520 --> 01:19:42,060
+دكت» «ميزونفريك دكت» «ميزونفريك دكت» «ميزونفريك
+
+798
+01:19:42,060 --> 01:19:50,260
+دكت» «ميزونفريك دكت» «ميزونفريك دكت» «ميزونفريك
+
+799
+01:19:50,260 --> 01:19:59,200
+دكت» «ميزيعني بيقولوا الـ Default يعني الإعداد
+
+800
+01:19:59,200 --> 01:20:06,700
+التلقائي الـ Default Development بتكون إنه الإنسان
+
+801
+01:20:06,700 --> 01:20:16,420
+بتحول إلى أنثى إذا فيه الـ Y-Chromosome ماشي بتحول
+
+802
+01:20:16,420 --> 01:20:23,340
+لدفع أما إذا مافيش Y-Chromosomeيعني وجود الـ X أو
+
+803
+01:20:23,340 --> 01:20:28,620
+أكثر من X أو عدد كبير من الـ X ما بيخلي الأنثى
+
+804
+01:20:28,620 --> 01:20:35,100
+تتكون عدم وجود الـ Y-Chromosome هو ما يدفع الـ
+
+805
+01:20:35,100 --> 01:20:41,560
+Development إلى قضية أن يكون الشخص هذا ذكر فوجود
+
+806
+01:20:41,560 --> 01:20:46,220
+الـ Y-Chromosome هو اللي بيصنع الـ Testes بيحول
+
+807
+01:20:46,220 --> 01:20:52,050
+إلى Testes وبيغير شكل القنواتبولية والقنوات
+
+808
+01:20:52,050 --> 01:20:58,390
+التناسلية بحيث إنه يعطي شكل الذكر في الـ Internal
+
+809
+01:20:58,390 --> 01:21:02,490
+والـ External Genitalia اللي هم الأعضاء التناسلية
+
+810
+01:21:02,490 --> 01:21:09,750
+الداخلية والقارجية البربخ والقنوات
+
+811
+01:21:09,750 --> 01:21:17,170
+تبعات الـ Sperms والبرستاتا
+
+812
+01:21:17,170 --> 01:21:25,120
+والذكر والأشياء هذهفي مقابل العدم موجود الـ Y
+
+813
+01:21:25,120 --> 01:21:28,740
+-Chromosome هو ما يدفع الـ Development إنه تتحول
+
+814
+01:21:28,740 --> 01:21:33,280
+باتجاه الأنثى وهي اللي بيسموها الـ Default يعني
+
+815
+01:21:33,280 --> 01:21:37,300
+هنا إذا مافيش أي مؤثر خارجي راح تمشي بهذا الطريق
+
+816
+01:21:37,300 --> 01:21:44,440
+فبتكون المبيض وبعدين قنوات Falloff وبعدين بقية
+
+817
+01:21:44,440 --> 01:21:50,190
+الرحم وقطعه وبعدين المهبل وغيرهالـ Female Internal
+
+818
+01:21:50,190 --> 01:21:56,510
+و External Genital ماشي فالإنسان
+
+819
+01:21:56,510 --> 01:22:06,270
+الطبيعي يعني عادة إذا ذكر XY إذا أنثى XX والأصل
+
+820
+01:22:06,270 --> 01:22:12,630
+يعني في التحكم إنه تروح باتجاه الذكر الذكورة هي
+
+821
+01:22:12,630 --> 01:22:19,880
+وجود الـXكثير من المظاهر مرتبطة بعد ما تتكون الـ
+
+822
+01:22:19,880 --> 01:22:24,280
+Testicles وتكون مصدر للهرمونات، الـTestosterone
+
+823
+01:22:24,280 --> 01:22:32,480
+وهو بيؤدي إلى إن المظاهر تتباع وتتغير وتكون بالشكل
+
+824
+01:22:32,480 --> 01:22:41,100
+اللي عندنا موجود فهي نواحي مهمة الآن في ظاهرة
+
+825
+01:22:41,100 --> 01:22:47,490
+حكينا عنها من قبلطبعًا الـ X-Chromosome أكبر بكثير
+
+826
+01:22:47,490 --> 01:22:52,690
+يعني الـ Chromosome محرز، كبير وفي عليه جينات
+
+827
+01:22:52,690 --> 01:22:57,790
+كثيرة وبلها دخل في أشياء كثيرة طبعًا أهم ميزة فيها
+
+828
+01:22:57,790 --> 01:23:02,670
+أو أهم مشكلة فيها أنه اللي لما يكون عندي نسخة
+
+829
+01:23:02,670 --> 01:23:08,730
+مريضة الـ Male راح يكون يأكل هوا لأنه لو نسخة
+
+830
+01:23:08,730 --> 01:23:13,390
+واحدة مافيش عنده مجال إذا بالذات Recessiveوهو يعني
+
+831
+01:23:13,390 --> 01:23:18,830
+صفة متنحية راح يكون إنها رغم إنها متنحية بس بتظهر
+
+832
+01:23:18,830 --> 01:23:25,990
+بالدكور فدايما يعني قضية الـ X-Chromosomes وأهميته
+
+833
+01:23:25,990 --> 01:23:32,510
+يعني شغل سبحان الله مهم كتير فلمّا
+
+834
+01:23:32,510 --> 01:23:39,330
+يكون الأنثى أو حتى لو ذكر مثلا XXY والـ XXY راح
+
+835
+01:23:39,330 --> 01:23:47,430
+يكون مظهريا إيش؟ ذكرلأنه عند الـY لما يكون XXY
+
+836
+01:23:47,430 --> 01:23:51,470
+الـTwo X دولة بيكونوا الشغالات أثنان وفي كل
+
+837
+01:23:51,470 --> 01:24:02,490
+الخلايا لو أنا بقدر أدرس بشكل عميق أنواع الـDNA
+
+838
+01:24:02,490 --> 01:24:08,510
+الشغال في كل خلية بلاقي إنه في حالة لما يكون عندي
+
+839
+01:24:08,510 --> 01:24:14,650
+أكتر من نسقة من الـXواحد منهم بس اللي شغالة فهنا
+
+840
+01:24:14,650 --> 01:24:18,870
+بيشرحوا Epigenetic وChromosomal Features و X
+
+841
+01:24:18,870 --> 01:24:23,070
+-Chromosome Inactivation in somatic cells ففي
+
+842
+01:24:23,070 --> 01:24:28,230
+الخلايا الجسمانية أي خلية صحيح أنها Two copies of
+
+843
+01:24:28,230 --> 01:24:34,290
+X-Chromosome بس واحدة بس منهم شغالة التانية بتكون
+
+844
+01:24:34,290 --> 01:24:41,480
+Silence وهذه الظاهرة بتحدث أولاًفي مرحلة مبكرة في
+
+845
+01:24:41,480 --> 01:24:46,920
+الـ Development بحيث إن مجموع الخلايا، نص الخلايا،
+
+846
+01:24:46,920 --> 01:24:51,600
+ربع الخلايا بتلاقي هذه الـ Copy هي الشغالة طبعاً
+
+847
+01:24:51,600 --> 01:24:55,760
+بتكون X-Chromosome أخذها الواحد مثلا أو أخذتها الـ
+
+848
+01:24:55,760 --> 01:25:02,070
+Female من والدها ومن والدتها، من الأب ومن الأمفإذا
+
+849
+01:25:02,070 --> 01:25:05,390
+بقدر أنا أفرّق إن هاي أجت من هون وهي أجت من هناك
+
+850
+01:25:05,390 --> 01:25:13,430
+بكون بلاقي في عندي واحدة بس هي لشغالة فالـ Gene
+
+851
+01:25:13,430 --> 01:25:20,590
+Expression الـ Active بكون هو اللي هو Active،
+
+852
+01:25:20,590 --> 01:25:28,210
+ماشي، الثاني Most Genes Are Silenced لحتى لما نقول
+
+853
+01:25:28,210 --> 01:25:31,780
+Silenceيعني هو أنا إذا عشان يحكوا التفاصيل أدق
+
+854
+01:25:31,780 --> 01:25:37,720
+شوية حوالي 15% are expressed to some degree يعني
+
+855
+01:25:37,720 --> 01:25:42,620
+حتى لما نقوله «inactive X-chromosome» مثلا في خلية
+
+856
+01:25:42,620 --> 01:25:47,460
+معينة مش كل الجينات على الـX-chromosome بتكون كلها
+
+857
+01:25:47,460 --> 01:25:54,420
+صفر وما بتشتغلش في نسبة قليلة بيكون، إيش هو اسمه؟
+
+858
+01:25:54,420 --> 01:25:58,020
+بيكون الـ«active»
+
+859
+01:26:00,510 --> 01:26:05,370
+لما أنا أدور على الـ DNA تبع الـ X-Chromosome في
+
+860
+01:26:05,370 --> 01:26:09,190
+هذه الحالة بكون على حالة الـ Euchromatin يعني
+
+861
+01:26:09,190 --> 01:26:18,510
+الكروماتين الحقيقي بمعنى إنه عبارة عن DNA مفروض مش
+
+862
+01:26:18,510 --> 01:26:24,130
+مضغوط وغير فاعل، لأ، مفروض ويتم استخدامه الـ
+
+863
+01:26:24,130 --> 01:26:28,910
+Inactive اللي هو اسمه الـ Bar Body، ماشياللي هو
+
+864
+01:26:28,910 --> 01:26:35,070
+يعني مضغوط ونايم وخارج طبعاً الـ «باربا» دي يعني
+
+865
+01:26:35,070 --> 01:26:42,210
+أنت بتعرفه جزء من بقصات التباتة الذكورة أو الأنوتة
+
+866
+01:26:42,210 --> 01:26:48,410
+أو كذا يعني لما نيجي نتكلم عن نفترض الألعاب
+
+867
+01:26:48,410 --> 01:26:54,920
+الأولومبية في واحدة أشطر ركيبة في الألعاب القوةصار
+
+868
+01:26:54,920 --> 01:27:01,420
+إن البنات التانية تقولوا لهذا زلمة مش أنثى
+
+869
+01:27:01,420 --> 01:27:08,060
+يعني، شايفين؟ فإذا الواحد باخد مسحة بسيطة من الحلق
+
+870
+01:27:08,060 --> 01:27:14,400
+وبروح بدور باستخدام الـChromatin وبيشوف Condensed
+
+871
+01:27:14,400 --> 01:27:20,360
+ولا لأ إذا فيه Bar Bodies بعرف إنه فيه X
+
+872
+01:27:20,360 --> 01:27:27,220
+-Chromosome، Inactiveفالحالة هذه يعني لو جيت أنا
+
+873
+01:27:27,220 --> 01:27:30,840
+وأنثى
+
+874
+01:27:30,840 --> 01:27:35,380
+مالكتش فيها ولا بعربة دي معناته هي مش أنثى حتى لو
+
+875
+01:27:35,380 --> 01:27:39,980
+مظهريًا وشكلًا بتبين كأنثى فهي بتحكي على أشياء
+
+876
+01:27:39,980 --> 01:27:44,560
+تانية فيه Non-Coding RNA اللي هو التفاصيل
+
+877
+01:27:44,560 --> 01:27:46,940
+والـHistone Variant اللي هو الـHistone
+
+878
+01:27:46,940 --> 01:27:48,860
+Modification اللي يعني
+
+879
+01:27:51,440 --> 01:27:56,600
+الـ Epigenetic Control من ناشب الكولوجيا أمثلة لـ
+
+880
+01:27:56,600 --> 01:28:07,500
+«So Far» بيحكوا عن محاولة فهم المرض وفهم الظاهرة
+
+881
+01:28:07,500 --> 01:28:12,320
+على أساس إن شاء الله بعدين يطلعون أدوية أو أساليب
+
+882
+01:28:12,320 --> 01:28:18,420
+تعديل أو أساليب علاج أو أدوية يعني هذه جزء من
+
+883
+01:28:18,420 --> 01:28:26,050
+التقدم العلمي الحالي إنهيحاولوا يدرسوها، فهذه الـ
+
+884
+01:28:26,050 --> 01:28:32,570
+Bar Bodies، ماشي، فهنا أمثلة، خلّينا نشوف الاتحاد،
+
+885
+01:28:32,570 --> 01:28:36,710
+وبعدين نطلع للدراسة، فهذه مثلا أنسة بختار
+
+886
+01:28:36,710 --> 01:28:44,370
+الطبيعية، واحد من الكروموزومات المفكوك وبيتم
+
+887
+01:28:44,370 --> 01:28:48,730
+استخدامه، وOne Bar Body، وهنا Two Bar Bodies،
+
+888
+01:28:48,730 --> 01:28:53,690
+Three Bar Bodies، Four Bar Bodies،يعني هاي عدد الـ
+
+889
+01:28:53,690 --> 01:29:02,090
+«كروموزومات» 49 وعندها X X X X X ناشي، تحدث، غادرة
+
+890
+01:29:02,090 --> 01:29:07,530
+جداً وإذا بدي أدور عليها يمكن ألاقيها وكذا بس يعني
+
+891
+01:29:07,530 --> 01:29:12,210
+الفكرة، انتبهوا هنا إنه دايماً سواء Male ولا
+
+892
+01:29:12,210 --> 01:29:16,870
+Female فيه one copy of X chromosome which is
+
+893
+01:29:16,870 --> 01:29:24,930
+activeاللي بيخلّي إنسان مهل هو الـ Y بغض النظر
+
+894
+01:29:24,930 --> 01:29:28,530
+يعني هو أنا حاطي نسخة أو نسختين أول مرة بشوف هيك
+
+895
+01:29:28,530 --> 01:29:37,710
+هي الـ XY-Chromosome أو XYY نفس الشيء أو XXY XXYY
+
+896
+01:29:37,710 --> 01:29:45,210
+يعني الدواهر الـ Non-disjunction دواهر عدم
+
+897
+01:29:45,210 --> 01:29:51,540
+الانفصال بين الـ X والـ Y-Chromosomeالـ Cell Cycle
+
+898
+01:29:51,540 --> 01:29:58,220
+أكثر من بقية الكرومزومات السبب إنه الواحد الكبير
+
+899
+01:29:58,220 --> 01:30:03,300
+وواحد صغير إنك تركّب اتنين واختلاف كبير في الحجم
+
+900
+01:30:03,300 --> 01:30:07,560
+بالبعض عشان ينفصلوا بشكل سليم هذا ما بيحدث
+
+901
+01:30:07,560 --> 01:30:15,160
+وبالتالي احتماليات الخلل أكبر فهيك أمثلة اسمها الـ
+
+902
+01:30:15,160 --> 01:30:21,280
+Bar Body اللي هو الـ Inactive X-Chromosomeوفي عنا
+
+903
+01:30:21,280 --> 01:30:26,340
+أمثلة على أحيانًا بتكون بهذا الشكل إن شاء الله
+
+904
+01:30:26,340 --> 01:30:34,880
+إنها واضحة بظن أنا صارت الساعة عشرة بنكمل إن شاء
+
+905
+01:30:34,880 --> 01:30:40,120
+الله يومبعد إذنك، يعني قبل ما تنهي، النقطة اللي
+
+906
+01:30:40,120 --> 01:30:43,520
+سأل عنها كريم بخصوص الـVariation في الـIndividual
+
+907
+01:30:43,520 --> 01:30:48,720
+Genomes يعني في .. مش عارف ايه، أظن أني موجود يا
+
+908
+01:30:48,720 --> 01:30:55,680
+كريم في Chapter رقم 4، صحيح؟ إذا بتسمعني كريم
+
+909
+01:30:55,680 --> 01:31:01,160
+Chapter رقم 4؟ آه، صحيح، موجود في Chapter رقم 4
+
+910
+01:31:01,160 --> 01:31:05,860
+آه، شو بدك؟ أنه واحدة؟النقطة الـ Variation في الـ
+
+911
+01:31:05,860 --> 01:31:10,140
+Individual Genomes يعني
+
+912
+01:31:10,140 --> 01:31:14,340
+إحنا كل المحاضرة عن إنه فيه Variation في الـ
+
+913
+01:31:14,340 --> 01:31:20,740
+Genome الـ Genome شو هو؟ الـ Genome هو مجمل المادة
+
+914
+01:31:20,740 --> 01:31:26,100
+الوراتية كلها لما نتكلم Genome يعني كل الـ DNA تبع
+
+915
+01:31:26,100 --> 01:31:32,880
+الكائن الإنساني هذا أو الإنسان هذا ففي عندي يعني
+
+916
+01:31:33,500 --> 01:31:39,160
+فأي نوع الـ Variation؟ هو له أنواع كثيرة لما يكون
+
+917
+01:31:39,160 --> 01:31:44,700
+يشوف اللي بحكي عنه يفرجيني يعني دكتور يعني خليني
+
+918
+01:31:44,700 --> 01:31:54,360
+أشاركلك الصورة اللي هو بعتلي إياها نعم، أه طيب،
+
+919
+01:31:54,360 --> 01:32:01,840
+أه، فرجيني الصورة
+
+920
+01:32:01,840 --> 01:32:07,200
+موجودة الآن هيهانعم إذا أنت شايفها؟ طيب، هسا هاي
+
+921
+01:32:07,200 --> 01:32:12,960
+نحكي عن حالة محددة اللي هي نوع من الـ Hemophilia
+
+922
+01:32:12,960 --> 01:32:20,020
+الـ Hemophilia اللي هو الـ Factor 8 تبع الـ
+
+923
+01:32:20,020 --> 01:32:26,100
+Clotting Factor تبع اللي بعمل تجلط الدم ماشي، دولة
+
+924
+01:32:26,100 --> 01:32:31,500
+موجودة على الـ X-Chromosome هسا اللي بيصير أحيانًا
+
+925
+01:32:31,770 --> 01:32:38,950
+ممكن مثلًا «Snip» أو «As if» «Deletion» «The One
+
+926
+01:32:38,950 --> 01:32:43,510
+Nucleotide» بيعمل «Frame Shift» بيخرّبلك كل
+
+927
+01:32:43,510 --> 01:32:49,830
+البروتين ويغلط الـ «DNA» يشغّل ماشي هنا ظاهرة
+
+928
+01:32:49,830 --> 01:32:56,970
+ثانية الظاهرة هذه إنه أنا في عندي قطعتين ممكن
+
+929
+01:32:56,970 --> 01:33:04,040
+هذولة يلبجوا على بعضفلمّا اللي هي ما بين النقطة A
+
+930
+01:33:04,040 --> 01:33:12,000
+والنقطة B فالأصل الـ «أصل» الـ «فاكتور 8» ماشي له
+
+931
+01:33:12,000 --> 01:33:23,880
+23 eggs on وبينهم 22 introns يعني لما أنا قاعد
+
+932
+01:33:23,880 --> 01:33:28,900
+أصنع البروتين هذا بسوي بالأول transcription
+
+933
+01:33:31,800 --> 01:33:38,700
+لدياء الـ RNA لكل الـ Introns والـ Exons وبعدين
+
+934
+01:33:38,700 --> 01:33:43,140
+بصير أقطع القطع واركبهم على بعض يعطيني البروتين
+
+935
+01:33:43,140 --> 01:33:47,220
+اللي أنا بديه واضح؟
+
+936
+01:33:47,220 --> 01:33:52,580
+في الحالة هذه، في بعض حالات الهيموفيليا اللي بيصير
+
+937
+01:33:52,580 --> 01:33:59,920
+أن هذولا القطعتين لا جات على بعض إذ ان احتمالي أنه
+
+938
+01:33:59,920 --> 01:34:08,420
+هيكيعني يشبك فلما يشبك وتيجي بعدين أنت تقول بدا
+
+939
+01:34:08,420 --> 01:34:14,140
+أفكه مرة ثانية بيصير الـ Loop بركب الطريقة معكوسة
+
+940
+01:34:14,140 --> 01:34:22,740
+فاهم عليك كيف الصورة حاطينها فاللي بيصير أن الـ AB
+
+941
+01:34:22,740 --> 01:34:28,400
+هذه القطعة اللي سببت الإشكالية راح تخليها تبدأ بدل
+
+942
+01:34:28,400 --> 01:34:34,540
+ما هو رقم 1تنين، تلاتي، لحد تلاتة وعشرين مظبوط
+
+943
+01:34:34,540 --> 01:34:38,540
+بهذا الشكل راح يصير اندي بيبدأ تنين وعشرين وواحد
+
+944
+01:34:38,540 --> 01:34:42,760
+وعشرين وكذا كذا لواحد وبعدين بيجي تلاتة وعشرين هنا
+
+945
+01:34:42,760 --> 01:34:48,800
+فراح يخربطلك الدنيا ويصير البروتين مالوش وظيفة ومش
+
+946
+01:34:48,800 --> 01:34:55,300
+كويس فاهم عليكي؟ فبعض حالات الـ Hemophilia
+
+947
+01:34:55,300 --> 01:35:05,150
+mutation بتكون بهذا الشكلوالسبب أنه يعني لما تدرس
+
+948
+01:35:05,150 --> 01:35:13,810
+بين الطبيعي وبين المصاب أول شيء كحجم DNA كامل
+
+949
+01:35:13,810 --> 01:35:19,590
+بتلاقي قطب بعض مافيش هلقلاق بس ترتيب القطع تبعات
+
+950
+01:35:19,590 --> 01:35:26,610
+الـ Egg Zone اللي هم بدخلوا فيه الـ Protein واللي
+
+951
+01:35:26,610 --> 01:35:31,600
+بينهم الـ Intronsهنا صارت الدنيا ملغوصة، مخربطة،
+
+952
+01:35:31,600 --> 01:35:36,520
+لا يمكن الاستفادة من هذا الاشياء وهذه بعض حالات
+
+953
+01:35:36,520 --> 01:35:48,120
+الـ Hemophilia وبتكون بهذا الشكل واضح؟ واضح كريم؟
+
+954
+01:35:48,120 --> 01:35:55,360
+تمام يا دكتور فهم علي، يعني هذه مثال أحيانًا يعني
+
+955
+01:35:55,360 --> 01:36:00,070
+اللي بدك تعرفها أنهالاختلالات الوراتية مش كلها على
+
+956
+01:36:00,070 --> 01:36:05,750
+طبيعة واحدة فقط يعني إن الـ «بروتين» أو الـ «جين»
+
+957
+01:36:05,750 --> 01:36:12,210
+مشيول تماماً، يعني غير موجود هذا «deletion» أي
+
+958
+01:36:12,210 --> 01:36:18,910
+طبيعة، بس هنا صار اللي هي قضية «reverse» الترتيب
+
+959
+01:36:18,910 --> 01:36:24,430
+القطع، في نفس الـ«جين» أحنا هنا مش جينات مختلفة،
+
+960
+01:36:24,430 --> 01:36:32,740
+فهذه أكزومللـ Hemophilia وهو مثال على الـ Genetic
+
+961
+01:36:32,740 --> 01:36:37,980
+Mutation بتخرّب الجين، بتخلّي الإنسان عنده نعور أو
+
+962
+01:36:37,980 --> 01:36:43,060
+Hemophilia وبيبطل يقدر يصنع البروتين هذا والسبب
+
+963
+01:36:43,060 --> 01:36:49,560
+أنه اختلف طريقة بطل صناعة البروتين بعدين كـ
+
+964
+01:36:49,560 --> 01:36:56,100
+Transcription و Translation بطلت تقدر تصنعه تمام؟
+
+965
+01:36:58,550 --> 01:37:01,650
+تمام، إن شاء الله هو يعني واضحة الصورة أعتقد عنده
+
+966
+01:37:01,650 --> 01:37:04,890
+في بس سؤال من بسمة بتسأل يعني الـBalance
+
+967
+01:37:04,890 --> 01:37:08,850
+Translocation يعني قصدك الـ… قصد على نفس الـslide
+
+968
+01:37:08,850 --> 01:37:15,130
+شكله؟ هاي، هنا بدك تعتبرها الـ… هنا مش
+
+969
+01:37:15,130 --> 01:37:18,570
+الـTranslocation، يعني الـTranslocation عمّا نحكي
+
+970
+01:37:18,570 --> 01:37:24,850
+عن Band، هنا إحنا بمستوى على one gene، يعني إحنا
+
+971
+01:37:24,850 --> 01:37:32,840
+هنا في مستوى أدقلما نحكي عن Band وقطع من الـ
+
+972
+01:37:32,840 --> 01:37:41,500
+Chromosomes وقطع أكبر، ماشي، إذا زي ما حطينا ال ..
+
+973
+01:37:41,500 --> 01:37:49,620
+إذا خليني أترجحكم صورة حطينا عن Down Syndrome Down
+
+974
+01:37:49,620 --> 01:37:56,220
+Syndrome Trisomy 21، واضح، عادة من هناكبس فيه نسبة
+
+975
+01:37:56,220 --> 01:38:04,520
+لما قاعد أدرس الـ الـ الـ الـ 21 Trisomy بلاقي
+
+976
+01:38:04,520 --> 01:38:10,900
+مافيش 21 Excess يعني فيه Two copies وبس فبكون إنه
+
+977
+01:38:10,900 --> 01:38:18,780
+فيه نسخة ثالثة راكبة على Chromosome 14 فهسة إذا
+
+978
+01:38:18,780 --> 01:38:24,770
+إنسان عندهنسخة واحدة فارضة فاضية من الـ Chromosome
+
+979
+01:38:24,770 --> 01:38:29,870
+21 والثاني الراكب على Chromosome 14 فبالأخير أنه
+
+980
+01:38:29,870 --> 01:38:33,230
+صار Two copies of Chromosome 21 وTwo copies of
+
+981
+01:38:33,230 --> 01:38:39,230
+Chromosome 14 وهذا Balance هذا هو نفسه إنسان طبيعي
+
+982
+01:38:39,230 --> 01:38:44,350
+لما يكون إنسان يكون Balance يعني كمية الـ DNA اللي
+
+983
+01:38:44,350 --> 01:38:50,010
+في جسمه الطبيعية مشابهة لكمية المتوقعة الطبيعية
+
+984
+01:38:50,380 --> 01:38:56,580
+وبالأخير مظهريًا لا يبدو عليه مرض ولكن تبتيب الـ
+
+985
+01:38:56,580 --> 01:39:03,220
+DNA لما بدي ييجي هو يخلف يصير تنقسم خلاياه وتعطي
+
+986
+01:39:03,220 --> 01:39:09,120
+الـ sperm والـ egg والـ ova وكذا بتلاقي إنه مستحيل
+
+987
+01:39:09,120 --> 01:39:15,380
+المربطين هذول أثنين مع بعض ينتصروا بشكل مناسب فإلا
+
+988
+01:39:15,380 --> 01:39:20,810
+الـ offspring cellsإلا يطلع ويا أما زيادة يا أما
+
+989
+01:39:20,810 --> 01:39:25,750
+نقصار واضح؟ فلما يكون الـ imbalance بتصير الأمراض
+
+990
+01:39:25,750 --> 01:39:34,410
+أكتر، بتكون فيه مشاكل أكتر، هذا المطلوب تمام
+
+991
+01:39:34,410 --> 01:39:38,710
+إن شاء الله إذا إن شاء الله نلتقي يوم الأربعة،
+
+992
+01:39:38,710 --> 01:39:44,710
+بنكمل على الحالات الثانية والأمراض الثانية، الله
+
+993
+01:39:44,710 --> 01:39:49,020
+يعطيكم ما يعطيهالله عفوك يا دكتور، يعطيك ألف عفو
+
+994
+01:39:49,020 --> 01:39:51,040
+أهلا وسهلا، السلام عليكم
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/SNmO_a0evPg_raw.json b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/SNmO_a0evPg_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..dd51abc704f7b1afefccc24c8ebcc5501e3429a6
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/SNmO_a0evPg_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 2856, "start": 0.0, "end": 28.56, "text": "الـ slide بالضبط أنه اللي قصده بدي يعني أتكلم عنه الفكرة إنه هناك درجة عالية من الاختلافات بين الـ DNA للبشر بحيث إنه بأي أسلوب أو بأي يعني عدسة مكبرة مستخدمة ممكن نلاقي درجات من الاختلافات في الـ SNAP", "tokens": [6027, 39184, 4137, 20666, 11242, 3555, 9566, 14739, 3224, 13672, 1829, 12174, 9381, 3215, 3224, 4724, 16254, 37495, 22653, 5551, 2655, 4117, 19528, 18871, 3224, 27188, 4117, 25720, 36145, 3224, 34105, 4117, 11778, 47341, 3660, 6225, 6027, 10632, 9154, 2423, 47283, 2655, 15040, 5172, 9307, 49374, 2423, 39184, 8272, 24976, 3555, 46309, 4724, 5016, 1829, 12984, 36145, 3224, 4724, 10721, 1829, 5551, 3794, 1211, 37746, 34051, 4724, 10721, 1829, 37495, 22653, 6225, 3215, 3794, 3660, 3714, 4117, 3555, 25720, 3714, 14851, 9778, 40448, 3660, 3714, 43020, 8717, 15040, 38436, 11778, 47341, 9307, 9154, 2423, 47283, 2655, 15040, 5172, 9307, 8978, 2423, 39184, 13955, 4715], "avg_logprob": -0.14866071315038773, "compression_ratio": 1.7512437810945274, "no_speech_prob": 1.8358230590820312e-05, "words": [{"start": 0.0, "end": 0.4, "word": "الـ", "probability": 0.900390625}, {"start": 0.4, "end": 0.88, "word": " slide", "probability": 0.181884765625}, {"start": 0.88, "end": 1.36, "word": " بالضبط", "probability": 0.924560546875}, {"start": 1.36, "end": 1.62, "word": " أنه", "probability": 0.68505859375}, {"start": 1.62, "end": 1.74, "word": " اللي", "probability": 0.940673828125}, {"start": 1.74, "end": 2.44, "word": " قصده", "probability": 0.9737548828125}, {"start": 2.44, "end": 3.22, "word": " بدي", "probability": 0.56304931640625}, {"start": 3.22, "end": 3.66, "word": " يعني", "probability": 0.6959228515625}, {"start": 3.66, "end": 4.5, "word": " أتكلم", "probability": 0.9488525390625}, {"start": 4.5, "end": 5.44, "word": " عنه", "probability": 0.95654296875}, {"start": 5.44, "end": 6.1, "word": " الفكرة", "probability": 0.9754231770833334}, {"start": 6.1, "end": 7.36, "word": " إنه", 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2100.0, "end": 2100.72, "word": " من", "probability": 0.88623046875}, {"start": 2100.72, "end": 2100.9, "word": " الـ", "probability": 0.6949462890625}, {"start": 2100.9, "end": 2101.04, "word": " 10", "probability": 0.78759765625}, {"start": 2101.04, "end": 2101.74, "word": ",000", "probability": 0.784423828125}, {"start": 2101.74, "end": 2102.64, "word": " pregnancies", "probability": 0.599365234375}, {"start": 2102.64, "end": 2103.32, "word": " يعني", "probability": 0.7724609375}, {"start": 2103.32, "end": 2103.7, "word": " 8", "probability": 0.302490234375}, {"start": 2103.7, "end": 2104.38, "word": "%", "probability": 0.9248046875}, {"start": 2104.38, "end": 2105.28, "word": " كان", "probability": 0.97412109375}, {"start": 2105.28, "end": 2105.82, "word": " فيهم", "probability": 0.9482421875}, {"start": 2105.82, "end": 2105.98, "word": " الـ", "probability": 0.766845703125}, {"start": 2105.98, "end": 2106.62, "word": " Chromosomal", "probability": 0.82861328125}, {"start": 2106.62, "end": 2107.18, "word": " Anomalies", "probability": 0.80859375}, {"start": 2107.18, "end": 2107.48, "word": " يعني", "probability": 0.833740234375}, {"start": 2107.48, "end": 2107.94, "word": " نسبة", "probability": 0.7691243489583334}, {"start": 2107.94, "end": 2108.68, "word": " محرزة", "probability": 0.852197265625}, {"start": 2108.68, "end": 2109.92, "word": " فيه", "probability": 0.5006103515625}, {"start": 2109.92, "end": 2110.8, "word": " Triploid", "probability": 0.7355143229166666}, {"start": 2110.8, "end": 2111.04, "word": " و", "probability": 0.88330078125}, {"start": 2111.04, "end": 2111.86, "word": " Tetraploid", "probability": 0.812744140625}, {"start": 2111.86, "end": 2112.8, "word": " يعني", "probability": 0.815185546875}], "temperature": 1.0}, {"id": 80, "seek": 214260, "start": 2113.64, "end": 2142.6, "text": "أحنا الأصل للإنسان إن الخلايا التابعتنا فيها 46 زوج ماشي، يعني 23 زوج، 46 كروموزوم الـ Triploid يعني تطلع اللي هو 23×3 بيصير إنها 69 كروموزوم", 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فهي حدوث مثل ذلك اختلال شديد، ظاهرة موجودة في الـ abortion اللي بيكمل الحمل ما بيكون احتمالي أن يكون عنده مثل ذلك ظاهرة", "tokens": [49628, 1829, 12984, 14739, 3224, 7251, 30544, 38637, 1211, 5718, 104, 8717, 3794, 9778, 4032, 51, 302, 424, 564, 17079, 37495, 22653, 14739, 3224, 48812, 25513, 4724, 10721, 25513, 27884, 6055, 1211, 9307, 4032, 3615, 46309, 9957, 4724, 10721, 25513, 27884, 37495, 22653, 4724, 1829, 9381, 13546, 28225, 42896, 3714, 29245, 23328, 8978, 33962, 15040, 25528, 6156, 3224, 1829, 11331, 3215, 2407, 12984, 50113, 1211, 29910, 23275, 1975, 46456, 1211, 6027, 13412, 16254, 3215, 12399, 1357, 116, 40294, 25720, 3714, 29245, 23328, 3660, 8978, 2423, 39184, 22902, 13672, 1829, 4724, 1829, 24793, 1211, 21542, 42213, 19446, 4724, 1829, 30544, 1975, 33753, 2304, 6027, 1829, 14739, 7251, 30544, 43242, 3224, 50113, 1211, 29910, 23275, 1357, 116, 40294, 25720], "avg_logprob": -0.24695445382494038, "compression_ratio": 1.6793248945147679, "no_speech_prob": 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{"start": 5682.76, "end": 5683.68, "word": " فراح", "probability": 0.9015299479166666}, {"start": 5683.68, "end": 5684.26, "word": " يخربطلك", "probability": 0.90380859375}, {"start": 5684.26, "end": 5684.98, "word": " الدنيا", "probability": 0.98486328125}, {"start": 5684.98, "end": 5685.76, "word": " ويصير", "probability": 0.96728515625}, {"start": 5685.76, "end": 5686.36, "word": " البروتين", "probability": 0.92724609375}, {"start": 5686.36, "end": 5686.92, "word": " مالوش", "probability": 0.9283447265625}, {"start": 5686.92, "end": 5688.34, "word": " وظيفة", "probability": 0.991455078125}, {"start": 5688.34, "end": 5688.8, "word": " ومش", "probability": 0.98486328125}, {"start": 5688.8, "end": 5689.5, "word": " كويس", "probability": 0.9915364583333334}, {"start": 5689.5, "end": 5690.78, "word": " فاهم", "probability": 0.9239908854166666}, {"start": 5690.78, "end": 5691.86, "word": " عليكي؟", "probability": 0.6490478515625}, {"start": 5691.86, "end": 5693.36, "word": " فبعض", 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"word": " زيادة", "probability": 0.97998046875}, {"start": 5960.47, "end": 5960.59, "word": " يا", "probability": 0.52978515625}, {"start": 5960.59, "end": 5960.81, "word": " أما", "probability": 0.980224609375}, {"start": 5960.81, "end": 5961.39, "word": " نقصار", "probability": 0.85333251953125}, {"start": 5961.39, "end": 5962.73, "word": " واضح؟", "probability": 0.78021240234375}, {"start": 5962.73, "end": 5963.29, "word": " فلما", "probability": 0.9020182291666666}, {"start": 5963.29, "end": 5963.83, "word": " يكون", "probability": 0.728271484375}, {"start": 5963.83, "end": 5963.95, "word": " الـ", "probability": 0.4918212890625}, {"start": 5963.95, "end": 5964.43, "word": " imbalance", "probability": 0.478271484375}, {"start": 5964.43, "end": 5965.33, "word": " بتصير", "probability": 0.6493326822916666}, {"start": 5965.33, "end": 5965.75, "word": " الأمراض", "probability": 0.9913736979166666}, {"start": 5965.75, "end": 5966.53, "word": " أكتر،", "probability": 0.739990234375}, {"start": 5966.53, "end": 5967.21, "word": " بتكون", "probability": 0.7919921875}, {"start": 5967.21, "end": 5967.45, "word": " فيه", "probability": 0.708740234375}, {"start": 5967.45, "end": 5967.89, "word": " مشاكل", "probability": 0.9879557291666666}, {"start": 5967.89, "end": 5968.59, "word": " أكتر،", "probability": 0.9619140625}, {"start": 5968.59, "end": 5968.75, "word": " هذا", "probability": 0.4228515625}, {"start": 5968.75, "end": 5969.51, "word": " المطلوب", "probability": 0.983642578125}, {"start": 5969.51, "end": 5974.41, "word": " تمام", "probability": 0.854736328125}, {"start": 5974.41, "end": 5974.59, "word": " إن", "probability": 0.394775390625}, {"start": 5974.59, "end": 5974.67, "word": " شاء", "probability": 0.982177734375}, {"start": 5974.67, "end": 5975.21, "word": " الله", "probability": 0.9638671875}, {"start": 5975.21, "end": 5976.09, "word": " إذا", "probability": 0.621826171875}, {"start": 5976.09, "end": 5976.31, "word": " إن", "probability": 0.86474609375}, {"start": 5976.31, "end": 5976.55, "word": " شاء", "probability": 0.95166015625}, {"start": 5976.55, "end": 5976.67, "word": " الله", "probability": 0.96923828125}, {"start": 5976.67, "end": 5977.25, "word": " نلتقي", "probability": 0.9300537109375}, {"start": 5977.25, "end": 5977.97, "word": " يوم", "probability": 0.98193359375}, {"start": 5977.97, "end": 5978.71, "word": " الأربعة،", "probability": 0.8270263671875}, {"start": 5978.71, "end": 5979.75, "word": " بنكمل", "probability": 0.9099934895833334}, {"start": 5979.75, "end": 5980.27, "word": " على", "probability": 0.90283203125}, {"start": 5980.27, "end": 5982.41, "word": " الحالات", "probability": 0.9703776041666666}, {"start": 5982.41, "end": 5982.93, "word": " الثانية", "probability": 0.8258056640625}, {"start": 5982.93, "end": 5983.61, "word": " والأمراض", "probability": 0.9166259765625}, {"start": 5983.61, "end": 5984.55, "word": " الثانية،", "probability": 0.85947265625}, {"start": 5984.55, "end": 5984.71, "word": " الله", "probability": 0.87255859375}, {"start": 5984.71, "end": 5985.15, "word": " يعطيكم", "probability": 0.9599609375}, {"start": 5985.15, "end": 5985.27, "word": " ما", "probability": 0.2445068359375}, {"start": 5985.27, "end": 5985.67, "word": " يعطيه", "probability": 0.6439208984375}], "temperature": 1.0}, {"id": 221, "seek": 599104, "start": 5986.46, "end": 5991.04, "text": "الله عفوك يا دكتور، يعطيك ألف عفو أهلا وسهلا، السلام عليكم", "tokens": [6027, 43761, 6225, 5172, 2407, 4117, 35186, 11778, 4117, 2655, 13063, 12399, 37495, 9566, 1829, 4117, 5551, 46538, 6225, 5172, 2407, 5551, 3224, 15040, 46952, 3224, 15040, 12399, 21136, 37440, 25894, 24793], "avg_logprob": -0.29829545454545453, "compression_ratio": 1.2619047619047619, "no_speech_prob": 0.0, "words": [{"start": 5986.46, "end": 5986.72, "word": "الله", "probability": 0.786376953125}, {"start": 5986.72, "end": 5987.0, "word": " عفوك", "probability": 0.7021484375}, {"start": 5987.0, "end": 5987.1, "word": " يا", "probability": 0.8271484375}, {"start": 5987.1, "end": 5988.04, "word": " دكتور،", "probability": 0.815283203125}, {"start": 5988.04, "end": 5988.6, "word": " يعطيك", "probability": 0.8856201171875}, {"start": 5988.6, "end": 5988.78, "word": " ألف", "probability": 0.908203125}, {"start": 5988.78, "end": 5989.02, "word": " عفو", "probability": 0.9698893229166666}, {"start": 5989.02, "end": 5989.76, "word": " أهلا", "probability": 0.734375}, {"start": 5989.76, "end": 5990.26, "word": " وسهلا،", "probability": 0.6683349609375}, {"start": 5990.26, "end": 5990.5, "word": " السلام", "probability": 0.879638671875}, {"start": 5990.5, "end": 5991.04, "word": " عليكم", "probability": 0.698974609375}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 5992.814875, "duration_after_vad": 5898.264093750038}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/SNmO_a0evPg_raw.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/SNmO_a0evPg_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..b8b1ae22c1e764fd988768f9b2f8e0821d43ef99
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/SNmO_a0evPg_raw.srt
@@ -0,0 +1,3976 @@
+1
+00:00:00,000 --> 00:00:05,440
+الـ slide بالضبط أنه اللي قصده بدي يعني أتكلم عنه
+
+2
+00:00:05,440 --> 00:00:14,660
+الفكرة إنه هناك درجة عالية من الاختلافات بين الـ
+
+3
+00:00:14,660 --> 00:00:22,460
+DNA للبشر بحيث إنه بأي أسلوب أو بأي يعني عدسة
+
+4
+00:00:22,460 --> 00:00:27,980
+مكبرة مستخدمة ممكن نلاقي درجات من الاختلافات في
+
+5
+00:00:27,980 --> 00:00:33,870
+الـ SNAPاللي هي Single Nucleotide Polymorphism فهي
+
+6
+00:00:33,870 --> 00:00:40,610
+بتكون على مستوى حرف واحد يعني على مستوى إذا
+
+7
+00:00:40,610 --> 00:00:50,090
+بتخيلنا الـ… الـGenome كل الـ… كل القصائد باللغة
+
+8
+00:00:50,090 --> 00:00:56,450
+العربية مثلا الـ… البروتين هو قصيدة محددة البروتين
+
+9
+00:00:56,450 --> 00:01:01,750
+بتكون من أحرفماشي لأن القصيدة تتكوّن من أبيات
+
+10
+00:01:01,750 --> 00:01:09,050
+والأبيات تتكوّن من أحرف فالـ… الـ Un-SNP هو اختلاف
+
+11
+00:01:09,050 --> 00:01:14,910
+في حرف واحد واتفقنا على إنه تقريبًا نتكلم على إنه
+
+12
+00:01:14,910 --> 00:01:19,570
+في حوالي من خمس إلى عشر مليون SNP عادةً في أي
+
+13
+00:01:19,570 --> 00:01:22,330
+جينوم بشري يعني
+
+14
+00:01:25,820 --> 00:01:34,280
+هي على مستوى الحرف الدقيق اللي هو المحدد يعني أما
+
+15
+00:01:34,280 --> 00:01:41,980
+لما نيجي نتكلم عن بالنسبة لـ… نيجي نتكلم على
+
+16
+00:01:41,980 --> 00:01:49,360
+مستويات أوسع من الـ… من الـVariation أو الاختلافات
+
+17
+00:01:49,360 --> 00:01:55,370
+ونشوف على مستوى أكبرأنا باعتبر هذا الـ «سلايد» من
+
+18
+00:01:55,370 --> 00:02:01,550
+أهم الـ «سلايدات» إذا بدي حد يقول فاهمان إشي يكون
+
+19
+00:02:01,550 --> 00:02:08,910
+منتبه له لما نيجي ندرس على مستوى الـ «كروموزوم»
+
+20
+00:02:08,910 --> 00:02:15,210
+كله والـDNA كله والجينوم كله هيك بشكل عام يعني
+
+21
+00:02:15,210 --> 00:02:21,650
+نعتبره بشكل مش دقيق كثير مش على مستوى الأحرار
+
+22
+00:02:22,150 --> 00:02:25,590
+بسميهم الـ Standard Karyotyping وحكيت لكم كيف
+
+23
+00:02:25,590 --> 00:02:29,750
+بيكون وبيكون على المستوى العشرة أو التسعة الـ
+
+24
+00:02:29,750 --> 00:02:33,890
+Nucleotide Base Pairs كلهم يعني المليارات مرة
+
+25
+00:02:33,890 --> 00:02:39,710
+واحدة هذا الـ Karyotyping إذا بتطلع على الـ Bands
+
+26
+00:02:39,710 --> 00:02:44,250
+اللي بشوفه باستخدام صبغات يا أما Routine Binding
+
+27
+00:02:44,250 --> 00:02:48,530
+أو High Resolution Binding يعنيبشوف الذفاقات
+
+28
+00:02:48,530 --> 00:02:53,330
+الموجودة على الكرموزومات وبحاول أدرسها في مستوى
+
+29
+00:02:53,330 --> 00:02:57,770
+أدق شوية، بعدين في عندى techniques هنا مجموعة
+
+30
+00:02:57,770 --> 00:03:05,530
+بالنص من أصعب الأشياء ويمكن لكل تشخيص فيه علية
+
+31
+00:03:05,530 --> 00:03:10,130
+معينة نستخدمها، اللي هي الـFish
+
+32
+00:03:10,130 --> 00:03:15,000
+والـMicrochromosome الـMicroarrayيعني هنا كأنه أنا
+
+33
+00:03:15,000 --> 00:03:22,440
+بصير أبحث في القصائد بشكل نسميهم أبيات شعر معينة
+
+34
+00:03:22,440 --> 00:03:27,820
+مثلا يمكن أصير تان فيهم نفس البيت أو إشي زي هيك
+
+35
+00:03:27,820 --> 00:03:32,220
+يعني مجموع أكبر شوية من هنا نبحث على لحظة محددة
+
+36
+00:03:32,670 --> 00:03:36,310
+وفيه لما أنا قاعد أفحص على مستوى الـ…
+
+37
+00:03:36,310 --> 00:03:40,990
+الـNucleotide والـBase Pair كل واحد لوحده بسوي
+
+38
+00:03:40,990 --> 00:03:44,790
+Whole Genome Sequencing هذه بيكون الـResolution
+
+39
+00:03:44,790 --> 00:03:50,550
+لحد واحد الـNucleotide تصير أخرها واحد واحد فهذه
+
+40
+00:03:50,550 --> 00:03:56,910
+يعني كل واحد منهم مفيد في حالة معينة، في تشخيص
+
+41
+00:03:56,910 --> 00:04:03,130
+معين، في مرض معين، لما يكون عندي مشاكلعلى شكل
+
+42
+00:04:03,130 --> 00:04:08,110
+مثلًا زي Down Syndrome لأ، المشكلة عادةً إنه
+
+43
+00:04:08,110 --> 00:04:14,750
+كروموزوم كامل فيه زيادة Trisomy 21 مثلًا بينما
+
+44
+00:04:14,750 --> 00:04:19,530
+مثلًا إذا بدور على مرض آخر يمكن أعمل Whole Genome
+
+45
+00:04:19,530 --> 00:04:25,490
+Sequencing فهذه باعتبره من أهم الـSlidesاللي لازم
+
+46
+00:04:25,490 --> 00:04:30,810
+واحد يتخيله ويعرفه ويعرف أمثلة عليه وشو وليش
+
+47
+00:04:30,810 --> 00:04:37,150
+بنحتاج في هذه الطريقة فالآن هاي اللي سموها الـ
+
+48
+00:04:37,150 --> 00:04:44,270
+Ideogram الـ G-banding النطاقات اللي هم الموجودين
+
+49
+00:04:44,270 --> 00:04:51,850
+على الـ كروموزومات لما نكون في مرحلة الـ Metaphase
+
+50
+00:04:51,850 --> 00:04:58,490
+من الـمن الـ Cell Division وبكون الـ DNA على شكل
+
+51
+00:04:58,490 --> 00:05:07,850
+DNA compressed يعني مضغوط وبكون على شكل أصغر إشي
+
+52
+00:05:07,850 --> 00:05:16,430
+حتى نقدر نقسم الـ الـ الـ two sets of chromosomes
+
+53
+00:05:16,430 --> 00:05:25,360
+to each cell فهذه بتكون كيف بتكون؟هنا رؤية أدق
+
+54
+00:05:25,360 --> 00:05:30,860
+ومقربة أكثر للـChromosome والـBands اللي موجودة
+
+55
+00:05:30,860 --> 00:05:36,020
+عليها وتقسيماتها وفيه High Resolution Banding يعني
+
+56
+00:05:36,020 --> 00:05:42,520
+حتى بيعطينا عدد أكبر من الدقة لنشوفه هون احنا
+
+57
+00:05:42,520 --> 00:05:48,020
+بنستخدم تقنية الـFish الـFluorescence اللي هي إنه
+
+58
+00:05:48,020 --> 00:05:54,880
+فيه صبغةبشيع عليها ضوء معين تعطيني ضوء ثاني فعادة
+
+59
+00:05:54,880 --> 00:06:00,000
+نختار أنواع الصدقات اللي بتعطينا فيها الـ Same
+
+60
+00:06:00,000 --> 00:06:04,240
+Excitation Wavelength للـ Laser أو للـ Light
+
+61
+00:06:04,240 --> 00:06:08,420
+وبتعطينا Different Emission Wavelength حتى أقدر
+
+62
+00:06:08,420 --> 00:06:16,500
+أميز أيش اللي بشوفه الـ Die هنا أنا حاططها على
+
+63
+00:06:16,500 --> 00:06:24,410
+ropeبتروح، بتدور على certain DNA sequence أنا مهتم
+
+64
+00:06:24,410 --> 00:06:32,510
+فيه، فهنا يعني أنا بدور الـ «قول» نثّلها على بيت
+
+65
+00:06:32,510 --> 00:06:40,370
+شعر معين في القصائد فبربط عليه مادة ملونة وبحطها
+
+66
+00:06:40,370 --> 00:06:44,550
+على الخلايا
+
+67
+00:06:44,550 --> 00:06:49,120
+اللي هي في حالةالـ Metaphase ويكون عندك روموزومات
+
+68
+00:06:49,120 --> 00:06:55,200
+وبحاول أشوف وين في اتصاق لهذه الـ Prop بالإيش
+
+69
+00:06:55,200 --> 00:06:59,640
+المركفق لها يعني إتلاقي البيت اللي أنا دورت عليه
+
+70
+00:06:59,640 --> 00:07:04,860
+من الشعب عشان تلزق عليه كمجموعة طويلة شوية مش
+
+71
+00:07:04,860 --> 00:07:11,000
+Single Nucleotide وهنا مرة بتاعة بنعتبرها إيجابي
+
+72
+00:07:11,000 --> 00:07:16,530
+ومرة بنعتبرها أساسيةهنا مثلاً الـ Binding تبع الـ
+
+73
+00:07:16,530 --> 00:07:23,810
+X-Chromosome ماشي وهكذا يكون شكله ويكون فيه حالات
+
+74
+00:07:23,810 --> 00:07:29,270
+مختلفة واشياء مختلفة الـ Microarray برضه يعني
+
+75
+00:07:29,270 --> 00:07:34,410
+فكرتها الأهم شيء الواحد ياخذها أن هنا أنا بدور على
+
+76
+00:07:34,410 --> 00:07:44,030
+بشكل عام علىالقطع DNA، يعني Sequence معين بيمكن
+
+77
+00:07:44,030 --> 00:07:51,410
+مثلًا خمسين، مائة Base محددة بترتيب معين يعني أحرف
+
+78
+00:07:51,410 --> 00:07:58,490
+معينة بتكون بشكل معين فهذه بدنا يعني تستطيع الواحد
+
+79
+00:07:58,490 --> 00:08:05,090
+يستخدمها ويدرس الموضوع وهي مفيدة إنه يتخيلها
+
+80
+00:08:05,090 --> 00:08:09,960
+الواحدفي تشريس حالة محددة، راح نحكي عن أنسلتها
+
+81
+00:08:09,960 --> 00:08:17,000
+وكيف تكون في سؤال من الدكتورة هديل، بتتكلم، بتسأل
+
+82
+00:08:17,000 --> 00:08:20,620
+يعني هل نعتبر الـSnips من ضمن الـPolymorphism
+
+83
+00:08:20,620 --> 00:08:24,540
+والـSubstitution ضمن الـMutation علما إن الأتنين
+
+84
+00:08:24,540 --> 00:08:29,260
+بيصير فيهم Single Base يعني؟ لأ، لأ، اسمعلي، كلمة
+
+85
+00:08:29,260 --> 00:08:38,990
+Polymorphism تعدد الصور، ماشي، هيالحالة عندما يكون
+
+86
+00:08:38,990 --> 00:08:47,790
+نسبة حدود هذه الطفرة ماشية أكثر من 1% من الـHuman
+
+87
+00:08:47,790 --> 00:08:54,510
+population يعني كلمة الـMutation okay يعني اللي هي
+
+88
+00:08:54,510 --> 00:08:59,890
+قضية كلمة إنه يقول طفرة الطفرة بدل واحد يعني يكون
+
+89
+00:08:59,890 --> 00:09:06,860
+متأكد أول شيء إنه هو تغير عن الطبيعي فيمكنأنا إذا
+
+90
+00:09:06,860 --> 00:09:11,260
+ما عندي دراسة كاملة لكل البشر بحيث أنا أعرف شهود
+
+91
+00:09:11,260 --> 00:09:18,400
+طبيعي حتى أقرر شهود مش طبيعي هنا بتصير الأمور يعني
+
+92
+00:09:18,400 --> 00:09:27,420
+صعبة شوية لتقييمها بينما عندما نتكلم عن كلمة كانت
+
+93
+00:09:27,420 --> 00:09:33,800
+ضمن تعريف الـPolymorphism إن نسبة حدوث هذه الظاهرة
+
+94
+00:09:34,510 --> 00:09:42,850
+بتكون بنسبة أكتر من 1% من الـ Population لما نتكلم
+
+95
+00:09:42,850 --> 00:09:50,430
+عن Snip، بالذات على مكان محدد، في محل محدد، في
+
+96
+00:09:50,430 --> 00:09:56,150
+دراسة معينة، ماشي عند مشاهدتها، بدنا نسميها Snip
+
+97
+00:09:56,150 --> 00:10:02,090
+هي كلهم أنواع تفرع الاختلاف
+
+98
+00:10:02,090 --> 00:10:08,390
+أنه حكيناالأنواع التانية من الـ Mutation اللي هي
+
+99
+00:10:08,390 --> 00:10:15,730
+إنها قطعة كبيرة تتكرر، قطعة كبيرة تنقلب تنسي إلى
+
+100
+00:10:15,730 --> 00:10:22,950
+inversion، قطعة كبيرة تنحذف، هاي في الغالب يعني
+
+101
+00:10:22,950 --> 00:10:27,890
+تأثيرها شديد على وظيفة الـ Protein والجين المعني
+
+102
+00:10:27,890 --> 00:10:35,680
+في هذه الظاهرة أو في هذه القطعةبينما لما نتكلم على
+
+103
+00:10:35,680 --> 00:10:41,940
+الـ SNP بالذات لدى الواحد يتذكر إن هما أشعة أنواع
+
+104
+00:10:41,940 --> 00:10:46,600
+التفرات أو أشعة أنواع الـ Mutations اللي بتحدث
+
+105
+00:10:46,600 --> 00:10:50,900
+ولكن قد يكون في أحيان كتيرة مالهاش قيمة يعني
+
+106
+00:10:50,900 --> 00:10:58,180
+وظيفياً هي غير فاعلة وغير مسببة لمرضيعني شغل
+
+107
+00:10:58,180 --> 00:11:02,720
+موجودة في الـ «DNA» على اتبين الاختلاف بين الـ
+
+108
+00:11:02,720 --> 00:11:07,480
+«DNA» تبع الأب من الأم في جيم معين بمكان معين وليس
+
+109
+00:11:07,480 --> 00:11:12,780
+بالضرورة أن ينتج عنها اختلال في وظيفة أو شكل أو
+
+110
+00:11:12,780 --> 00:11:16,540
+تركيب البروتين الناتج إن شاء الله أن الأمر واضح
+
+111
+00:11:16,540 --> 00:11:22,080
+دكتور، هي بتسأل برضه إنه يعني الفرق بين
+
+112
+00:11:22,080 --> 00:11:25,380
+الـMutation والـPolymorphism هو النسب؟
+
+113
+00:11:28,000 --> 00:11:36,580
+الإثنين تقريبًا مترادفان يعني نسب تعتبر يعني
+
+114
+00:11:36,580 --> 00:11:42,280
+التعدد الصور بافتراض إنه يعني مثلًا أنا في مكان
+
+115
+00:11:42,280 --> 00:11:46,720
+معين عندي صور تاني، ثلاثة بين البشر، ماشي الطفرة
+
+116
+00:11:46,720 --> 00:11:51,400
+إذا في شيء كان الأصل يكون موجود و بعدين صارت
+
+117
+00:11:51,400 --> 00:11:54,720
+تغيّر، اختلاف
+
+118
+00:11:55,130 --> 00:12:01,570
+بين الوالدين والإبن أو البنت يعني إنه تغير شيء صار
+
+119
+00:12:01,570 --> 00:12:08,470
+يتطور لما نستخدم polymorphism يعني حتى يعني يعرفوه
+
+120
+00:12:08,470 --> 00:12:15,790
+بشكل أكتربيقول إن نسبته كتفرة في المجتمع أو في
+
+121
+00:12:15,790 --> 00:12:20,890
+اللي عندها قيام بالدراسة أكثر من 1% يعني الأقل من
+
+122
+00:12:20,890 --> 00:12:25,190
+1% لا تُعتبر Polymorphism يعني هيك مرات تعتبروها
+
+123
+00:12:25,190 --> 00:12:33,030
+بس الـSNP يعني هو هنا ما ممكنش نعتبره Polymorphism
+
+124
+00:12:33,030 --> 00:12:38,150
+لجين معين يعني مع أنه كلمة Polymorphism داخل فيه
+
+125
+00:12:38,150 --> 00:12:47,110
+يعنيسلانه قد لا يكون دقيق ماشي أنا راحة صورتي
+
+126
+00:12:47,110 --> 00:12:55,240
+بعرفش أوي بده أشوف وين أناعشان… ما هو اسمه؟ المهم،
+
+127
+00:12:55,240 --> 00:13:00,320
+طبعاً برضه لسه يعني وضحة النقطة بالنسبة لها بس
+
+128
+00:13:00,320 --> 00:13:05,460
+يعني بتقول إنه حتى الطفرات اللي بقطعة كبيرة زي
+
+129
+00:13:05,460 --> 00:13:09,440
+الـCopy Number Variant ممكن مايكونش لها قيمة لو
+
+130
+00:13:09,440 --> 00:13:15,800
+كانت non-coding region لما نخطط بالشكل الصحيح
+
+131
+00:13:15,800 --> 00:13:25,530
+طبعاًوهذه يعني من الـ نسميها من الظواهر اللي تعطي
+
+132
+00:13:25,530 --> 00:13:33,050
+الإنسان خاصية أكتر إنه الـ DNA عنده بتتحمل إنه
+
+133
+00:13:33,050 --> 00:13:40,510
+يكون هناك فترات كثيرة بس إذا في مكانمالوش قيمة،
+
+134
+00:13:40,510 --> 00:13:45,250
+صح، مش راح يكون له قيمة الدكتورة أسماء برضه يعني
+
+135
+00:13:45,250 --> 00:13:49,610
+بتطلب إذا كان فيه ممكن شرح الـSlider رقم 7 مش عارف
+
+136
+00:13:49,610 --> 00:13:53,810
+أيه قصدها في المحاضرة هذه وصلت دكتور أنت للـSlider
+
+137
+00:13:53,810 --> 00:14:01,650
+رقم 7 في المحاضرة؟ والله الـSlider رقم 7 اللي هو
+
+138
+00:14:01,650 --> 00:14:03,710
+الـMicro Array
+
+139
+00:14:06,230 --> 00:14:11,190
+الـ «هذا ما تاخدوش تفاصيل الـ «هذا ما تاخدوش
+
+140
+00:14:11,190 --> 00:14:12,470
+تفاصيل الـ «هذا ما تاخدوش تفاصيل الـ «هذا ما
+
+141
+00:14:12,470 --> 00:14:12,550
+تاخدوش تفاصيل الـ «هذا ما تاخدوش تفاصيل الـ «هذا
+
+142
+00:14:12,550 --> 00:14:13,290
+ما تاخدوش تفاصيل الـ «هذا ما تاخدوش تفاصيل الـ
+
+143
+00:14:13,290 --> 00:14:14,490
+«هذا ما تاخدوش تفاصيل الـ «هذا ما تاخدوش تفاصيل
+
+144
+00:14:14,490 --> 00:14:14,990
+الـ «هذا ما تاخدوش تفاصيل الـ «هذا ما تاخدوش
+
+145
+00:14:14,990 --> 00:14:15,050
+تفاصيل الـ «هذا ما تاخدوش تفاصيل الـ «هذا ما
+
+146
+00:14:15,050 --> 00:14:23,090
+تاخدوش تفاصيل الـ «هذا ما تاخدوش تفاصيل الـ «هذا
+
+147
+00:14:23,090 --> 00:14:35,750
+ما تاخدوش تفاص
+
+148
+00:14:35,860 --> 00:14:42,080
+اللي بتدور على الخلل اللي أنا بتوقع يكون موجود،
+
+149
+00:14:42,080 --> 00:14:46,900
+ماشي؟ ربما مش قصد عن الـSlider هذه، تقصد الـSlider
+
+150
+00:14:46,900 --> 00:14:51,300
+اللي بعدها كمان هدولة نفس الفكرة، يعني
+
+151
+00:14:51,300 --> 00:14:55,100
+الـMicroarrays،
+
+152
+00:14:55,100 --> 00:15:03,600
+ماشي؟ يعني هنا إذا أنا مش يعني أحكي لكم قصص، ماشي؟
+
+153
+00:15:04,330 --> 00:15:12,550
+في أنا الفترة الأخيرة التقيت بعائلة إخواننا من
+
+154
+00:15:12,550 --> 00:15:19,530
+سوريا لاجئين في القردن يعني فعندهم حالة هجيبلكم
+
+155
+00:15:19,530 --> 00:15:27,150
+صورة إيديهم وجريهم المحاضرة الجاية ماشي عليهم يعني
+
+156
+00:15:27,150 --> 00:15:33,790
+إشي غريب جداً أقرب شيء وإذا حدا بينكم بيحاول يشوفه
+
+157
+00:15:34,230 --> 00:15:41,570
+اسمه «Infantile Digital Fibromatosis» يعني عبارة
+
+158
+00:15:41,570 --> 00:15:46,930
+عن خلّيني أنا أبعتلك الصورة يا دكتور أحمد على
+
+159
+00:15:46,930 --> 00:15:53,110
+الـWhatsApp إلىك، ماشي؟ إن شاء الله ولمّا تيجي
+
+160
+00:15:53,110 --> 00:15:59,610
+أعرضها عندك بإذن الله يا تعالى فهدولة العائلة هذه
+
+161
+00:16:00,220 --> 00:16:05,620
+الوالد والوالدة درجة أولى أقارب ولاد عم ولاد خالة
+
+162
+00:16:05,620 --> 00:16:11,380
+يعني فيه قرابة والشغل
+
+163
+00:16:11,380 --> 00:16:19,900
+التاني أنه عبارة عن هما تسع أخوة وأخوات أربعة
+
+164
+00:16:19,900 --> 00:16:29,730
+مصابين وأربعة مش مصابين، ماشي؟فهينبعدتلك الصور أنت
+
+165
+00:16:29,730 --> 00:16:38,410
+دخلهم للشباب والدكتورات فالآن
+
+166
+00:16:38,410 --> 00:16:46,330
+أنا شاكك بشكل كبير جداً أن هذا مرض وراقي وأشك أنه
+
+167
+00:16:46,330 --> 00:16:57,390
+يعني إذا كان منديلي يعني كانناتج عن خلل في جين
+
+168
+00:16:57,390 --> 00:17:04,470
+واحد ماشي بيكون autosomal
+
+169
+00:17:04,470 --> 00:17:10,030
+dominant لأن الذكور والإناث زي بعض مافيش اختلافات
+
+170
+00:17:10,030 --> 00:17:20,090
+بينهموالشغل التاني أنه الكل يعني ال .. ال .. ال ..
+
+171
+00:17:20,090 --> 00:17:24,390
+بالنسبة لل .. أنه كل الأفراد يعني فيه بكور وفيه
+
+172
+00:17:24,390 --> 00:17:31,370
+إينات ومن العائلة بالكامل فيه ناس فيهم مصابين ففي
+
+173
+00:17:31,370 --> 00:17:38,210
+مثل هيك حالة شاورت مع تعيين الأمراض الوراثية عندنا
+
+174
+00:17:39,120 --> 00:17:47,020
+المشكلة أنه أنا ماعندي تخيل سابق لوين الأنول الجين
+
+175
+00:17:47,020 --> 00:17:51,320
+المسؤول عن هذه الظاهرة ماعندي أي تخيأ فكرة سابقة
+
+176
+00:17:51,320 --> 00:17:55,820
+أنول البروتين، أنول الجين، يعني لو أنا والله عند
+
+177
+00:17:55,820 --> 00:17:59,200
+إنسان عنده مشكلة بالـHemoglobin أنا بعرف إن
+
+178
+00:17:59,200 --> 00:18:03,800
+الـAlpha والـBeta Chain تبعات الـHemoglobin هم
+
+179
+00:18:03,800 --> 00:18:08,560
+اللي بيبقوا codes for this problem فلما أنا ألاقي
+
+180
+00:18:09,110 --> 00:18:14,090
+إنسان أو عيلة فيها مشكلة مش مو… مش عارف أنا
+
+181
+00:18:14,090 --> 00:18:19,310
+ماعنديش أي تخيل وين راح يكون الفرق أو وين راح يكون
+
+182
+00:18:19,310 --> 00:18:23,910
+الخلل الموجود أو سببه لازم أنا من الطرف الحالي هذه
+
+183
+00:18:23,910 --> 00:18:27,850
+أعمل Whole Genome Sequence يعني لازم أقرأ تسع
+
+184
+00:18:27,850 --> 00:18:32,870
+مليارات وأقارن في التسع مليارات بين الناس اللي
+
+185
+00:18:32,870 --> 00:18:39,160
+عندهم مرض واللي ماعندهم مش مرض فاهم عليك إيه؟ففي
+
+186
+00:18:39,160 --> 00:18:43,640
+اللحظة هذه أنا بحتاج لهذا اللوع من البحث إذا عندي
+
+187
+00:18:43,640 --> 00:18:49,020
+تصور سابق مثلًا نحكي على إنه فيه إيش اسمه «Dijord
+
+188
+00:18:49,020 --> 00:18:52,900
+Syndrome» بحكي لكم عنه الـ «Dijord Syndrome» إله
+
+189
+00:18:52,900 --> 00:18:56,800
+يعني التوقع إنه في مكان معين، في الـChromosome
+
+190
+00:18:56,800 --> 00:19:00,250
+الإفلانيفي المنطقة الفلانية، في الـBand الفلانية
+
+191
+00:19:00,250 --> 00:19:06,210
+بس مش لسه Gen ولا Snip أنا بتكلم عنه أنا بتكلم هنا
+
+192
+00:19:06,210 --> 00:19:13,690
+عن قطعة أكبر شوية بيكون فيها خلط فالفكرة
+
+193
+00:19:13,690 --> 00:19:22,530
+اللي بدنا نحكيها اللي هي إنه لما أنا آجي أعمل
+
+194
+00:19:22,530 --> 00:19:25,970
+Whole Genome Sequencing يعني في ظاهرة بنحكي عنها
+
+195
+00:19:25,970 --> 00:19:31,830
+ممكن بعدين بتفاصيلهنا عملية إنه أنا بصير أقطع الـ
+
+196
+00:19:31,830 --> 00:19:36,610
+DNA باستخدام إنزيمات Restriction enzymes أو إنزام
+
+197
+00:19:36,610 --> 00:19:40,710
+معينة Restriction enzymes مرات نستخدمها لما نحكي
+
+198
+00:19:40,710 --> 00:19:45,600
+عن إنه إشي بقطع البروتينبقطعه بأماكن محددة بين كل
+
+199
+00:19:45,600 --> 00:19:50,000
+Two amino acids مثلا بشكل معين يعني فبنفس الفكرة
+
+200
+00:19:50,000 --> 00:19:54,420
+الـ… الـEnzymes التبعات اللي بتساوي الـDigestion
+
+201
+00:19:54,420 --> 00:20:00,420
+للـDNA عشان نعمله بقطع معينة يكون فيها Overlap
+
+202
+00:20:00,420 --> 00:20:05,800
+نقدر نرسم صورة عن الجميع وبتكون في الحالة هذه أنا
+
+203
+00:20:05,800 --> 00:20:10,440
+بحاجة أعمل Whole Genome Sequence Analysis وبعدين
+
+204
+00:20:10,440 --> 00:20:16,790
+بسير أدورعلى 9 مليارات وين فيه اختلافة بين المصاب
+
+205
+00:20:16,790 --> 00:20:25,050
+وبين السليم يعني هي الفكرة تبعها في أسئلة الـ
+
+206
+00:20:25,050 --> 00:20:39,030
+هنا حكينا إنه تقريبًا تقريبًا يعني 0.6، 0.7% من
+
+207
+00:20:39,030 --> 00:20:46,880
+الـ newbornماشي، بكون فيه لما تعمل Carrier Type
+
+208
+00:20:46,880 --> 00:20:53,220
+بكون فيه عندك روموزوم الـ Anomalous يعني نص
+
+209
+00:20:53,220 --> 00:20:59,220
+بالمية، نعتبرها الجد يعني يعني كل 200 جنين واحد
+
+210
+00:20:59,220 --> 00:21:06,470
+بيطلع فيه عنده مشكلة على مستوى روموزوم كامليعني
+
+211
+00:21:06,470 --> 00:21:12,510
+تعتبر قطعة كبيرة جداً من الـDNA فحدوث اختلالات في
+
+212
+00:21:12,510 --> 00:21:18,850
+الـChromosomes وارد، موجود، مؤثر، بدنا نعرف إنه
+
+213
+00:21:18,850 --> 00:21:23,050
+موجود الـChromosome،
+
+214
+00:21:23,050 --> 00:21:30,050
+هذه النسبة اللي هي تقريباً 0.5، 0.6% لسه لو ده
+
+215
+00:21:30,050 --> 00:21:35,100
+ناخذ الـStilbirds، ناخذ الـAbortionsالإيجادات
+
+216
+00:21:35,100 --> 00:21:42,020
+الذاتية في أشهر الحملة الأولى هذه بتكون نسبتها
+
+217
+00:21:42,020 --> 00:21:48,960
+عالية وبتكون موجودة، ماشي فحتى بتكون نسبتها أعلى
+
+218
+00:21:48,960 --> 00:21:54,300
+من هذه النسبة يعني هذه newborn يعني ولادة صارت أنه
+
+219
+00:21:54,300 --> 00:22:01,860
+ولد طبيعي يعني فهذه النسب موجودة بس في ظاهرة أخرى
+
+220
+00:22:01,860 --> 00:22:09,580
+أنه أحياناً الخللإنه أنسختين للـ Chromosome صار
+
+221
+00:22:09,580 --> 00:22:14,680
+انتقال لقطع كبيرة من محل لمحل ثاني من الـ
+
+222
+00:22:14,680 --> 00:22:20,420
+Chromosome الأول فصار صغير أو قصير للـ Chromosome
+
+223
+00:22:20,420 --> 00:22:29,180
+الثاني اللي صار حجمه أكبر فهذه الظاهرة هي تسمى الـ
+
+224
+00:22:29,180 --> 00:22:36,810
+Balanced Translocation يعني اختلالفي مكان القطعة
+
+225
+00:22:36,810 --> 00:22:46,170
+الكبيرة بحيث إنه بالمحصلة المادة الوراثية تبع هذا
+
+226
+00:22:46,170 --> 00:22:52,550
+الإنسان بتكون كاملة، بتكون طبيعية الـTotal طبيعي،
+
+227
+00:22:52,550 --> 00:23:01,890
+بس مكانه غلط فلما يكون وجود Balance Translocation
+
+228
+00:23:01,890 --> 00:23:11,630
+ماشيهذه بتكون نتيجتها إن نفس الشخص هذا بيكون طبيعي
+
+229
+00:23:11,630 --> 00:23:19,670
+بس إنه بالنسبة للـ «بروجينيت» تبعته ولاده وبناته
+
+230
+00:23:19,670 --> 00:23:26,450
+بعدين راح تصير فيه إشكاليات إنه لما يصير الخلايا
+
+231
+00:23:26,450 --> 00:23:30,050
+المطلوبة منها تنقص بشكل سليم في بعض الخلايا راح
+
+232
+00:23:30,050 --> 00:23:36,530
+تكونعند DNA ناقص ويمكن هذا يكون غير حي ولا يعيش
+
+233
+00:23:36,530 --> 00:23:41,250
+وإنه يكون فيه إيش زايد يكون يعطينا مرض هاي قضية
+
+234
+00:23:41,250 --> 00:23:45,610
+الـStructural Abnormalities وهمية إن تكون Balanced
+
+235
+00:23:45,610 --> 00:23:50,470
+أو Unbalanced وكيف تأثيرها الشغل الثاني الـ
+
+236
+00:23:50,470 --> 00:23:56,610
+Unemployed يعني اختلال عدد نسخ وكمية
+
+237
+00:23:56,610 --> 00:24:01,550
+الـChromosomesاللي هي راح نحكي عنها عملية عدم
+
+238
+00:24:01,550 --> 00:24:07,710
+انتصال الـChromosomين عن بعض بشكل سليم وبالذات هي
+
+239
+00:24:07,710 --> 00:24:11,930
+أكثر للـXY-Chromosome بس ممكن حتى في
+
+240
+00:24:11,930 --> 00:24:17,690
+الـChromosomات التانية في أسلة هنا
+
+241
+00:24:17,690 --> 00:24:24,450
+ليستة أرجو أنكم تحفظوها يعني لما تيجي تقرا و بعدين
+
+242
+00:24:27,860 --> 00:24:35,400
+التقارير عن أي مرض وتحاولوا تفهموا شو اللي بيحكوا
+
+243
+00:24:35,400 --> 00:24:40,060
+عنه كحدث اللي حصل على مستوى المادة الورافية والـ
+
+244
+00:24:40,060 --> 00:24:47,180
+DNA وكيف صار، فإذا كتبوا الديل «Deletion»إذا كان
+
+245
+00:24:47,180 --> 00:24:51,540
+حاطين إشارة زائد فإنه صار زيادة في الوظيفة أو
+
+246
+00:24:51,540 --> 00:24:58,120
+نقصان في الوظيفة أو هناك يعني في نفس الجسم خلايا
+
+247
+00:24:58,120 --> 00:25:02,560
+بتكون بشكل وخلايا ثانية بتكون بشكل آخر إنه بيكون
+
+248
+00:25:02,560 --> 00:25:09,020
+فعلا مزيكيزم مزيق ماشي اللي هي إنه يعني زي الـ
+
+249
+00:25:11,210 --> 00:25:16,310
+الأنظمة أو الشكل إنه بيكون من أكثر من نوع مثلا من
+
+250
+00:25:16,310 --> 00:25:21,990
+بلاط بلاط لون معين وبلاط لون تاني مثلا قضية الـ
+
+251
+00:25:21,990 --> 00:25:26,550
+Translocation روبرسين Translocation Rain
+
+252
+00:25:26,550 --> 00:25:30,890
+Chromosome يعني الأشياء اللي موجودة هذه جدول
+
+253
+00:25:32,000 --> 00:25:39,080
+كمصطلحات لأ مهم وكويس الواحد يفهمه عشان لما نقرأ
+
+254
+00:25:39,080 --> 00:25:45,260
+يعني هنا كمثال لكل واحد منهم شو معناه وشو بدل على
+
+255
+00:25:45,260 --> 00:25:54,580
+إيش أن نكون بذلك الشكل هاي كمان يعني أسلوب يعني
+
+256
+00:25:54,580 --> 00:26:03,070
+لما نحطونا رسمات زي هيك ماشي هو بيحطنماذج مختلفة
+
+257
+00:26:03,070 --> 00:26:11,750
+للتجارب المخبرية لتشكيص هذه الحالة فالـ Trisomy 21
+
+258
+00:26:11,750 --> 00:26:19,170
+اللي هو Down Syndrome ماشي، الـ Trisomy 21 ممكن
+
+259
+00:26:19,170 --> 00:26:25,690
+أنا في الـ A حطيت اللي هو Karyotype فأنا بشغته
+
+260
+00:26:25,690 --> 00:26:33,220
+بهذا الشكلهذه كريوتيب وبيكون برائيسوم 21 ممكن أنا
+
+261
+00:26:33,220 --> 00:26:39,280
+أستخدم الـ Fluorescence Fish اللي هي Fluorescence
+
+262
+00:26:39,280 --> 00:26:45,720
+In Cytohybridization for Chromosome 21 ويعني هنا
+
+263
+00:26:45,720 --> 00:26:51,360
+بيطلع ليه إن أنا عندي تلت نسخة ماشي يعني يمكن هو
+
+264
+00:26:51,360 --> 00:26:56,960
+الأحمر فبكون إنه في هذه الخليةبكون عندي ثلاث نسخ
+
+265
+00:26:56,960 --> 00:27:00,980
+من هذا الأحمر كروموزوم ثاني عشان أتأكد إن أنا شغلي
+
+266
+00:27:00,980 --> 00:27:07,700
+مظبوط خطيت عليه صبغة خضراء وبالتالي انبين عندي إن
+
+267
+00:27:07,700 --> 00:27:12,520
+أنا في نسختين أنا مش أنا بالغلط صار Overlap بين
+
+268
+00:27:12,520 --> 00:27:18,440
+خليتين وفي حياتي إنه بعندي أنا أكتر من نصفة يعني
+
+269
+00:27:18,440 --> 00:27:24,850
+من زيادة من خلية أكتر من خليةفهنا، هاي نوع من الـ
+
+270
+00:27:24,850 --> 00:27:29,250
+FISH اللي هو In-Situ Hybridization تستخدمان تقنيات
+
+271
+00:27:29,250 --> 00:27:36,350
+مختلفة فاللي بعدها، اللي دلوقت يقرا اللي هو
+
+272
+00:27:36,350 --> 00:27:39,470
+Chromosomal
+
+273
+00:27:39,470 --> 00:27:44,750
+Microarray واستخدام
+
+274
+00:27:44,750 --> 00:27:49,790
+يعني اللي هو الـMicroarrays اللي هي الأسلوب الثالث
+
+275
+00:27:51,810 --> 00:28:00,170
+بشوف هنا الكروموزومات تبع الإنسان والأصل اللي هي
+
+276
+00:28:00,170 --> 00:28:07,530
+2M يعني النسختين من الـ من الـ الـ DNA ولا
+
+277
+00:28:07,530 --> 00:28:11,930
+الكروموزوم بتكون في هذا النطاق حسب هذا الفحث بلاقي
+
+278
+00:28:11,930 --> 00:28:19,430
+هنا الكروموزوم 21 عالي كتيروعرفت أنه يعني ثلاث نسخ
+
+279
+00:28:19,430 --> 00:28:24,570
+بدل ما هو من نسختين العادى لو كان فيه مثلا نفترض
+
+280
+00:28:24,570 --> 00:28:30,810
+أنا شخصيت «تيرنر سندروم» ما تعرفوا عنه يكون XO
+
+281
+00:28:30,810 --> 00:28:34,610
+يكون «one copy of X» باجي لو باجي بعمل
+
+282
+00:28:34,610 --> 00:28:38,410
+الـ«microarray» هذا باستخدم للـX-Chromosome كان
+
+283
+00:28:38,410 --> 00:28:43,580
+بلاقي الطفل هذه أو الإنسان هذه جاي يروحبتلاقي إذا
+
+284
+00:28:43,580 --> 00:28:47,720
+كان فوق معناته زيادة إذا كان تحت معناته فيه نقص
+
+285
+00:28:47,720 --> 00:28:55,960
+فهي الفكرة هنا كله لنفس التشخيص لنفس الظاهرة ولكن
+
+286
+00:28:55,960 --> 00:29:03,680
+باستخدام وسائل مخبرية مختلفة يعني كل واحد منهم إيه
+
+287
+00:29:03,680 --> 00:29:07,900
+إيجابيات وإيه سلبيات إيه نقاط قوة بس فيه إيه نقاط
+
+288
+00:29:07,900 --> 00:29:12,680
+ضعفوضروري الواحد ينتبه لهذه الأشياء لما يفكر كيف
+
+289
+00:29:12,680 --> 00:29:22,480
+يشخص هذا الحالة في أسئلة؟ لأن نوعيات الـ
+
+290
+00:29:22,480 --> 00:29:29,920
+Translocation وأنواعها Balanced وUnbalanced وبكون
+
+291
+00:29:29,920 --> 00:29:37,380
+في أن ومكان بين كذا وكذا يعني هذه الظواهر تحدث
+
+292
+00:29:38,300 --> 00:29:45,240
+فيه ظواهر موجودة وأحيانًا يعني في حالات معينة
+
+293
+00:29:45,240 --> 00:29:52,440
+بيكون فيها إلى حتى دور وظيفي للمرض اللي بنشوفه
+
+294
+00:29:52,440 --> 00:29:59,660
+يعني مثلًا المرض من أنواع السرطانات اللي هو
+
+295
+00:29:59,660 --> 00:30:06,260
+«Chronic Myeloid Leukemia» الـ «CML» الـ «CML» من
+
+296
+00:30:06,260 --> 00:30:10,750
+الأشياء المميزة لهاللي هي موضوع بيسموه الـ
+
+297
+00:30:10,750 --> 00:30:13,750
+Philadelphia chromosome الـ Philadelphia
+
+298
+00:30:13,750 --> 00:30:19,630
+chromosome عبارة عن Translocation
+
+299
+00:30:19,630 --> 00:30:27,330
+بين قطعتين من الـ DNA بحيث إنه في الـ PCR اللي هو
+
+300
+00:30:27,330 --> 00:30:32,570
+الـ B cell receptor gene يعني عبارة عن مكان معين
+
+301
+00:30:32,570 --> 00:30:37,230
+في الخلايا الليمباوية الخلايا الليمباوية بس إله
+
+302
+00:30:37,230 --> 00:30:44,600
+دخلفي بقاء الخلايا ومعيشة الخلايا وحياة الخلايا
+
+303
+00:30:44,600 --> 00:30:51,340
+عدم إنها تتوفى بالـ Apoptosis وفي الـ ABL-Gene
+
+304
+00:30:51,340 --> 00:30:56,020
+اللي دخل بالـ Longevity تبعته فهدولة الأصل قطعتين
+
+305
+00:30:56,020 --> 00:30:59,840
+في الـ DNA بعاد عن بعض ولمّا ييجي في الـ
+
+306
+00:30:59,840 --> 00:31:02,340
+Philadelphia chromosome أو في اللي عندهم هذه الـ
+
+307
+00:31:02,340 --> 00:31:06,440
+Genetic Mutation يصيروا جانب بعض وبكون نتيجة
+
+308
+00:31:06,440 --> 00:31:13,110
+اختلالفي وظيفة الخلية فهذه كلها ضواهر يعني أنا أظن
+
+309
+00:31:13,110 --> 00:31:22,750
+إنه الآن المطلوب الفهم العام وليس المقصود التفاصيل
+
+310
+00:31:22,750 --> 00:31:28,950
+حدوث هذه الأشياء لما يكون الـ Translocation
+
+311
+00:31:28,950 --> 00:31:35,390
+والاختلال دلوقتي بقوله Balanced البلاء أقل المرض
+
+312
+00:31:35,390 --> 00:31:42,330
+أخفرإنه على الأقل هذا الإنسان عنده كمية DNA كافية
+
+313
+00:31:42,330 --> 00:31:49,470
+وطبيعية ومتوقعة بس وين تواجدها شرط بطاقة مع بعض
+
+314
+00:31:49,470 --> 00:31:54,670
+كيف علاقتها في بعض هو اللي بيصير خلافات وهذه راح
+
+315
+00:31:54,670 --> 00:31:58,450
+تنتج عندها مشاكل في الذرية تبع هذا الإنسان في
+
+316
+00:31:58,450 --> 00:32:07,590
+ولاده وبناته الـ هنادراسة يعني مهم الواحد يتطلع
+
+317
+00:32:07,590 --> 00:32:15,450
+عليها ويكون يتخيلها على نسبة احتمالات الأمراض
+
+318
+00:32:15,450 --> 00:32:22,210
+الوراثية اللي هي الـ Whole Genome أو Whole
+
+319
+00:32:22,210 --> 00:32:26,490
+Chromosome الدراسة
+
+320
+00:32:26,490 --> 00:32:33,010
+هذه على 10,000 حالة ولادة، ماشي؟
+
+321
+00:32:36,020 --> 00:32:40,660
+ويعني حاطين هنا زي ما ذكرت أكتر شوية من المرة اللي
+
+322
+00:32:40,660 --> 00:32:45,360
+فاتت الـ Spontaneous Abortion والـ Live Born
+
+323
+00:32:45,360 --> 00:32:52,380
+Infant يعني الـ إثنينلو صار Abortion يقضوا يدرسوا
+
+324
+00:32:52,380 --> 00:32:56,340
+كيف وضع الـ «Karyotype» شو اللي نوعين المشكلة
+
+325
+00:32:56,340 --> 00:33:03,700
+الموجودة أو حدوث إجهاد ذاتي
+
+326
+00:33:03,700 --> 00:33:08,520
+spontaneous الآن
+
+327
+00:33:08,520 --> 00:33:13,480
+نشوف كام نسب الاختلالات في الـChromosomes كلها
+
+328
+00:33:13,480 --> 00:33:20,020
+فهنا أنا استخدمتاللي هو بن قوسين الـ Karyotype
+
+329
+00:33:20,020 --> 00:33:28,340
+يعني حتى أطلّع مثل إيه نتاج الحالات
+
+330
+00:33:28,340 --> 00:33:33,440
+اللي عملوها الدراسة هذه، العشر تلات كان 1500
+
+331
+00:33:33,440 --> 00:33:40,940
+abortion، 15% و8500 يعني 85% live birth
+
+332
+00:33:44,320 --> 00:33:50,120
+بالنسبة للـ Live Birds من الـ 8500 فيه خمسين كان
+
+333
+00:33:50,120 --> 00:33:54,220
+عندهم كروموزوم الـ Anomalous بينما بالـ
+
+334
+00:33:54,220 --> 00:34:00,660
+Spontaneous Abortions 750 من الـ 1500 كان عندهم
+
+335
+00:34:00,660 --> 00:34:09,880
+Abnormal Chromosome يعني الـ بالذات في عند حدوث
+
+336
+00:34:09,880 --> 00:34:16,500
+الإجهاب الذاتي المرأة الحاملفي الأشهر الأولى نتكلم
+
+337
+00:34:16,500 --> 00:34:22,220
+حتى غالبًا أول ثلاث أشهر هذه راح يكون في الغالب في
+
+338
+00:34:22,220 --> 00:34:29,720
+أنها Abnormal chromosomal defect يعني مشكلة كبيرة
+
+339
+00:34:29,720 --> 00:34:36,880
+بالنسبة لكل كمية كبيرة من الـ DNA وهذه يعني حتى لو
+
+340
+00:34:36,880 --> 00:34:42,920
+صار Life birth ممكن أحيانًا يكون في نسبة من أمراض
+
+341
+00:34:42,920 --> 00:34:48,940
+مثل ذلكالآن، ما هي أنواع المشاكل اللي بتوقع الواحد
+
+342
+00:34:48,940 --> 00:34:54,020
+أو اللي لقوها في الحلقة؟
+
+343
+00:34:54,020 --> 00:35:01,740
+يعني، مع الـ Abortion 800 حالة Total من الـ 10,000
+
+344
+00:35:01,740 --> 00:35:06,620
+pregnancies يعني 8% كان فيهم الـ Chromosomal
+
+345
+00:35:06,620 --> 00:35:11,040
+Anomalies يعني نسبة محرزة فيه Triploid و
+
+346
+00:35:11,040 --> 00:35:17,180
+Tetraploid يعنيأحنا الأصل للإنسان إن الخلايا
+
+347
+00:35:17,180 --> 00:35:26,440
+التابعتنا فيها 46 زوج ماشي، يعني 23 زوج، 46
+
+348
+00:35:26,440 --> 00:35:38,780
+كروموزوم الـ Triploid يعني تطلع اللي هو 23×3
+
+349
+00:35:38,780 --> 00:35:46,270
+بيصير إنها 69 كروموزومبحيث أنه يكون ثلاث نسخ
+
+350
+00:35:46,270 --> 00:35:51,970
+وTetraploid يعني أنه ضرب بأربعة تلات وعشرين بأربعة
+
+351
+00:35:51,970 --> 00:35:59,170
+يعني بيصير 92 chromosome موجود في الخلايا فهي حدوث
+
+352
+00:35:59,170 --> 00:36:05,370
+مثل ذلك اختلال شديد، ظاهرة موجودة في الـ abortion
+
+353
+00:36:05,370 --> 00:36:11,450
+اللي بيكمل الحمل ما بيكون احتمالي أن يكون عنده مثل
+
+354
+00:36:11,450 --> 00:36:20,370
+ذلك ظاهرةI متوقع يكون موجودة الوفيات أو الـ
+
+355
+00:36:20,370 --> 00:36:26,010
+spontaneous abortions والجاذات كان
+
+356
+00:36:26,010 --> 00:36:34,190
+فيه 140 Turner اللي هو XO بس نصها واحدة من الـ X
+
+357
+00:36:34,190 --> 00:36:40,650
+مافيش Y أو X تانية وبالنسبة للـ Live Birds كان فيه
+
+358
+00:36:40,650 --> 00:36:46,420
+احتمالية واحدةيعني من 10,000 pregnancies بتوقع
+
+359
+00:36:46,420 --> 00:36:57,020
+الواحد واحد Turner يكون يعني موجود يعني، فطلعت
+
+360
+00:36:57,020 --> 00:37:02,540
+الـSlide دكتورة
+
+361
+00:37:02,540 --> 00:37:05,580
+اسمها، إذا بتسأل ممكن توضيح لظاهرة
+
+362
+00:37:05,580 --> 00:37:11,700
+الـIsochromosome عبارة عن إيش هي بتطلع؟من إيش قديم
+
+363
+00:37:11,700 --> 00:37:14,840
+ولا فيها الـ «سلايد»؟ لأ، أعتقد في الـ «سلايد»
+
+364
+00:37:14,840 --> 00:37:25,280
+السابق يعني، «ظاهرة الـ Isochromosome» الأسئلة
+
+365
+00:37:25,280 --> 00:37:30,360
+دا فيها أي واحد عنده سؤال يوقف وقتها، شايف عليه؟
+
+366
+00:37:30,360 --> 00:37:40,310
+يعني الـ «إنفرجل لوبز» والأشكال الأخرى من الـأشكال
+
+367
+00:37:40,310 --> 00:37:45,550
+شكل الكروموزوم وارتباطاتهم مع بعض اللي هم أكتر من
+
+368
+00:37:45,550 --> 00:37:52,050
+شكل ودولة يعني خلّينا اليوم نوقفهم على إنهم أمثلة
+
+369
+00:37:52,050 --> 00:37:59,310
+للاختلالات اللي ممكن تحدث تفاصيل ليش حدثت وكذا
+
+370
+00:37:59,310 --> 00:38:05,690
+اليوم والآن إذا ما إلها نصيب بعدين نرجحها في مرض
+
+371
+00:38:05,690 --> 00:38:11,380
+معين أو إذا نتناقش عن حالة معينةماشي، ما بديش
+
+372
+00:38:11,380 --> 00:38:17,140
+مياها يعني الآن هذه الأشياء اللي هنا يعني الظواهر
+
+373
+00:38:17,140 --> 00:38:25,140
+في اختلال التركيب تبع الـ DNA كـChromosome كشكل
+
+374
+00:38:25,140 --> 00:38:31,320
+كله إذا الاختلال، بالأخير كمية الـ DNA Balance
+
+375
+00:38:31,320 --> 00:38:36,940
+متوازنة مع الطبيعي، بالغالب نفس الشخص ماعندوش
+
+376
+00:38:36,940 --> 00:38:43,070
+مشكلةبس بتسوي مشاكل في ذريته لأنه بترجع الخلايا
+
+377
+00:38:43,070 --> 00:38:46,670
+بده لازم تتقسم بالنص مظبوط فبصير فيه جزء و فيه
+
+378
+00:38:46,670 --> 00:38:52,430
+زيادة و فيه جزء و فيه نقصان يعني هنا الـ «هاي»
+
+379
+00:38:52,430 --> 00:38:58,310
+أمثلة على الأشياء اللي ممكن تحدث الأمثلة
+
+380
+00:38:58,310 --> 00:39:03,230
+على اللي الآن بنحكيها وصلت أنا للـ45XO اللي هو
+
+381
+00:39:03,230 --> 00:39:12,120
+الـTurner هذهيعني في خلل وفي مرض وفي عدم نمو طبيعي
+
+382
+00:39:12,120 --> 00:39:20,920
+ومشاكل كثيرة بس بيظل أنه يعنيبالذات لأن الـ Y
+
+383
+00:39:20,920 --> 00:39:25,840
+-Chromosome مش مهم كثير كان خواص للحياة كثيرة
+
+384
+00:39:25,840 --> 00:39:31,500
+وكذلك الـ X التاني أصلاً بتأثر نصهم في نفس القلاية
+
+385
+00:39:31,500 --> 00:39:34,980
+أو اللي هي الـ Ionization اللي حنا نحكي عنه فهو
+
+386
+00:39:34,980 --> 00:39:39,020
+يعتبر شيء خفيف يعني هو أشياء واحدة في مرات بيكون
+
+387
+00:39:39,020 --> 00:39:47,020
+ممكن أنه يكون الإنسانيكمل لإنه يتم ولادته «Trisomy
+
+388
+00:39:47,020 --> 00:39:54,120
+16» و«Trisomy 18» بتحدث بالنسبة أكبر بكتير بالـ
+
+389
+00:39:54,120 --> 00:40:01,160
+Abortion لإنها غير يعني متوافقة مع الحياة بس ممكن
+
+390
+00:40:01,160 --> 00:40:05,660
+يوصل إنه طفل يولد فيها بس بطولش بعدها يعني
+
+391
+00:40:05,660 --> 00:40:10,840
+«Trisomy 21» راح ناخد عنه بعدين اللي هو Down
+
+392
+00:40:10,840 --> 00:40:16,390
+Syndromeوفيه ممكن Other Types of Trisomy فيه الـ…
+
+393
+00:40:16,390 --> 00:40:20,790
+الـAnomalies بالـX والـY كرمزومز فيه أشكال، أنواع،
+
+394
+00:40:20,790 --> 00:40:24,750
+كده وفيه الـUnbalanced والـBalanced Rearrangements
+
+395
+00:40:24,750 --> 00:40:31,010
+فالسة اللي قاعدة بتسأل عنه الدكتورة والأنواع
+
+396
+00:40:31,010 --> 00:40:35,930
+هنا شرّينها بس في أنه يعني تذكروا أنه فيه Balance
+
+397
+00:40:35,930 --> 00:40:40,220
+وفيه Unbalanced Rearrangementكل ما كانت Unbalanced
+
+398
+00:40:40,220 --> 00:40:46,240
+راح يكون الوضع أسوأ، ماشي؟ يعني هنا هاي Balanced
+
+399
+00:40:46,240 --> 00:40:54,960
+تقريبًا في مجال 16 حالة كانت أنه Balance يعني هاي
+
+400
+00:40:54,960 --> 00:41:00,580
+الحمل هذا كمل عند الولادة، يعني مش الحال أما لما
+
+401
+00:41:00,580 --> 00:41:06,800
+يكون Unbalanced، الوضع بيكون بالعكسبحيث أنه يعني
+
+402
+00:41:06,800 --> 00:41:11,780
+ما بعيشي كثير والـBalance لسه كمان هذا ما بنقول
+
+403
+00:41:11,780 --> 00:41:16,140
+هذه الصفة الوراثية بعدين لأنه صحيح Balance
+
+404
+00:41:16,140 --> 00:41:20,460
+Rearrangement في هذا الإنسان هو طبيعي كمية الـDNA
+
+405
+00:41:20,460 --> 00:41:27,960
+عنده طبيعية بس لما نيجي يحاول يعمل خلايا للتكاتر
+
+406
+00:41:27,960 --> 00:41:35,740
+راح يكون فيها مشاكل أكترفبعتبر هذه جدول من أهم
+
+407
+00:41:35,740 --> 00:41:41,080
+الجداول لنسب في إحدى الدراسات واللي هو الرجع ممكن
+
+408
+00:41:41,080 --> 00:41:46,680
+واحد يرجعله ممكن في مجتمع آخر ذا في أرقام مختلفة
+
+409
+00:41:46,680 --> 00:41:50,820
+نوعًا ما ولكن يعني أنا أظن إنه هيك تقريبًا في
+
+410
+00:41:50,820 --> 00:41:55,660
+العالم كله بهذا الشكل وعدد الولادات بشكل طبيعي
+
+411
+00:41:55,660 --> 00:41:59,280
+منطقتنا العربية الإسلامية الزواج الأقارب
+
+412
+00:42:02,020 --> 00:42:06,520
+كان فيه غرافية معينة يعني فيه فرق بين البيض والسود
+
+413
+00:42:06,520 --> 00:42:11,540
+والسخر والأجناس
+
+414
+00:42:11,540 --> 00:42:18,280
+المختلفة فيها سلة فيها
+
+415
+00:42:18,280 --> 00:42:26,100
+سلة إحنا هيك خلصنا يعني أنا النقطة اللي بدنا
+
+416
+00:42:26,100 --> 00:42:32,880
+نذكرهااللي هي يعني المبدأ الأساسي أنا باعتبره اللي
+
+417
+00:42:32,880 --> 00:42:43,700
+الواحد يكون يكون من تباهيله اللي هو قضية إنه أنا
+
+418
+00:42:43,700 --> 00:42:51,780
+حتى إذا شكيت في عيب معين ومشكلة معينة يجب أن يكون
+
+419
+00:42:51,780 --> 00:42:58,000
+عندي الأداء المناسبة لدراسة هذا الشيءحطينا مثال
+
+420
+00:42:58,000 --> 00:43:05,760
+الـ الـ خلينا نسألها سؤال لما حطينا مثال قبل شوية
+
+421
+00:43:05,760 --> 00:43:14,700
+عن اللي هو اللي لما عملوا دراسة عن الـ Down
+
+422
+00:43:14,700 --> 00:43:20,020
+Syndrome اللي هي هذه شو الـ Test اللي ما حطهوش حتى
+
+423
+00:43:20,020 --> 00:43:24,620
+يقرأوا هذا الموضوع؟ من يعني
+
+424
+00:43:25,930 --> 00:43:31,770
+الشيء اللي هو فعلاً منطقي وما حطوه ضمن هذه الدراسة
+
+425
+00:43:31,770 --> 00:43:35,090
+يعني
+
+426
+00:43:35,090 --> 00:43:40,050
+هنا حطيه الـ Karyotype وحطيه أنواع من الأشياء
+
+427
+00:43:40,050 --> 00:43:44,210
+الوسط اللي هو الـMicroarray الـBinding ما Binding
+
+428
+00:43:44,210 --> 00:43:47,350
+مش جايبين سيرتها بس واضحة الأمور يعني لأن
+
+429
+00:43:47,350 --> 00:43:54,070
+الـChromosome كبير وواضح الفكرة يعني في حدا بده
+
+430
+00:43:54,070 --> 00:43:57,890
+يجاوبدكتورة أسماء بتحكي حكات قبل ما تتكلم أنت حكت
+
+431
+00:43:57,890 --> 00:44:04,010
+الـ Binding لأ الـ Binding هنا ماشي بس إيش ال ..
+
+432
+00:44:04,010 --> 00:44:08,930
+إيش الكبير أو اللي كانت تقنية أهم واحد من أهم
+
+433
+00:44:08,930 --> 00:44:11,890
+الأشياء الـ .. الدكتورة السياسية بتقول الـ
+
+434
+00:44:11,890 --> 00:44:16,770
+Electrophoresis ممكن؟ لأ مش الـ Electrophoresis
+
+435
+00:44:16,770 --> 00:44:20,910
+الـ Electrophoresis هدولة اللي .. اللي تحتها الـ T
+
+436
+00:44:20,910 --> 00:44:26,030
+ثانثة تنتينماشي، فيهم الـ Electrophoresis حتى تشوف
+
+437
+00:44:26,030 --> 00:44:31,450
+الواحد الكمية تبعته الواضح أنه أدنى وأدقشي الـ
+
+438
+00:44:31,450 --> 00:44:33,590
+Whole Sequencing الدكتورة بسمعك الـ whole genome
+
+439
+00:44:33,590 --> 00:44:38,530
+sequencing دكتورة بسمعك ليش تقعد تقرأ كل حرف بحرف
+
+440
+00:44:38,530 --> 00:44:44,920
+وما أنت شايف فتعة كبيرة زايدة، ماشي؟فإنك هنا تطلب
+
+441
+00:44:44,920 --> 00:44:49,260
+Whole-Genome Sequencing وانت بتقول دهنك إنه بفكر
+
+442
+00:44:49,260 --> 00:44:53,680
+في Down Syndrome مش منطقي لإنك بتضيع المصارع
+
+443
+00:44:53,680 --> 00:44:58,760
+الفاضية بتعمل فحص مش ضروري فاهم عليك؟ لما بدك تشك
+
+444
+00:44:58,760 --> 00:45:02,980
+في حالة بدك تدرس جانب معين بدك تستخدم الأداء
+
+445
+00:45:02,980 --> 00:45:07,740
+المناسب خاينة الطبيعة، ماشي؟
+
+446
+00:45:07,740 --> 00:45:16,160
+فالآن اليوم راح نتكلمالـChromosomal Genomic Basis
+
+447
+00:45:16,160 --> 00:45:20,540
+of Disorders of the Autosomes and Sex Chromosomes
+
+448
+00:45:20,540 --> 00:45:25,580
+يعني نرجع مرة تانية نرجع
+
+449
+00:45:25,580 --> 00:45:30,080
+مرة تانية لأشياء
+
+450
+00:45:30,080 --> 00:45:36,060
+القريبة اللي أخذناها منها يعني اللي هو من الـslide
+
+451
+00:45:36,060 --> 00:45:40,200
+الأخير الـ
+
+452
+00:45:42,020 --> 00:45:50,960
+النقطة الأولى، ماشي، ليش؟ يعني وين الإشكالية حتى
+
+453
+00:45:50,960 --> 00:45:55,640
+تحدث مثل هذه الأشياء؟ إن يصير عندي خلل في عدد
+
+454
+00:45:55,640 --> 00:46:04,940
+الكرموزومات أو خلل في وجودها وكذا أهم واحد أنا
+
+455
+00:46:04,940 --> 00:46:08,380
+باعتبر، يعني على الأقل هيك للواحد حتى يفهمها اللي
+
+456
+00:46:08,380 --> 00:46:12,670
+هي Abnormal Chromosomal Segregationيعني الـ Non
+
+457
+00:46:12,670 --> 00:46:21,170
+-Disjunction يعني الفكرة هنا إنه أنا في ظاهرة
+
+458
+00:46:21,170 --> 00:46:26,610
+انقسام الخلية حكينا على إنه بالـ Metaphase لازم
+
+459
+00:46:26,610 --> 00:46:34,570
+بالنصف، في المستوى المنصف للخلية تيجي الكرمозومات
+
+460
+00:46:34,570 --> 00:46:42,230
+كلها بتصف جن بعضكل اتنين تقبل بعض مظبوطات وفيه
+
+461
+00:46:42,230 --> 00:46:48,950
+Central Zones على الطرفين وفيه قيوط الـ Spindle
+
+462
+00:46:48,950 --> 00:46:57,370
+Fibers اللي هي زي العضلات بتجذب القطعتين هدولة
+
+463
+00:46:57,370 --> 00:47:06,210
+للطرفين، ماشي؟ يعني هو اللي بتكلموا عنه إذا لسبب
+
+464
+00:47:06,210 --> 00:47:14,440
+ماكان عدم انفصال نظيف، كامل، سليم بين الـTwo
+
+465
+00:47:14,440 --> 00:47:18,740
+copies راح يصير عندي ما يسمونه «non-disjunction»
+
+466
+00:47:18,740 --> 00:47:24,340
+يعني إنه ما انفصلوش عن بعض بشكل سليم راح يكون عندي
+
+467
+00:47:24,340 --> 00:47:29,360
+نتيجة هذا الأمر يا إما الإثنين كلهم يروحوا على
+
+468
+00:47:29,360 --> 00:47:33,180
+الجهة واحدة وبالتالي الجهة الثانية، يعني الـTwo
+
+469
+00:47:33,180 --> 00:47:36,810
+copies كلهم يروحوا الجهة واحدةوالجهة التانية ما
+
+470
+00:47:36,810 --> 00:47:40,570
+راح يروحلها إشي من هذا الـ Search من الـ
+
+471
+00:47:40,570 --> 00:47:47,270
+Chromosomes أو إن أحيانًا أنه يعني واحد ونص يروح
+
+472
+00:47:47,270 --> 00:47:55,350
+هذه الجهة ونص يروح هناك، ماشي نتيجة هذا الأمر يعني
+
+473
+00:47:55,350 --> 00:48:04,170
+راح يكون Unemployed يعني تغير في عدد النساءماشي،
+
+474
+00:48:04,170 --> 00:48:07,830
+زي الـDown Syndrome الـKleinfilter وReverent
+
+475
+00:48:07,830 --> 00:48:14,210
+Dysentery وأشياء يعني من الأمثلة على الأمراض إنه
+
+476
+00:48:14,210 --> 00:48:20,090
+تكون عندي يا إما زيادة يا إما نقصة Recurrent
+
+477
+00:48:20,090 --> 00:48:24,290
+chromosomal syndromes Dyadic chromosomal anomalies
+
+478
+00:48:24,290 --> 00:48:27,790
+Unbalanced familial anomalies Abnormalities
+
+479
+00:48:27,790 --> 00:48:32,390
+Syndromes Endowing Genetic Genomic Imprinting
+
+480
+00:48:32,810 --> 00:48:43,070
+الباقية بدّيش يعني يعني بدّيش مش مهم كتير أحفظ
+
+481
+00:48:43,070 --> 00:48:48,630
+وأفهم ليش بتصير وكيف بتصير وكده يعني حكينا قبل
+
+482
+00:48:48,630 --> 00:48:54,030
+شوية عن إنه إذا في balance translocation موجود في
+
+483
+00:48:54,030 --> 00:49:00,460
+شخص معين هذا رح يعمل مشكلة ويكون في الـالـ
+
+484
+00:49:00,460 --> 00:49:05,640
+Progeny، الذرية تبع هذا الإنسان نفسه هو ممكن ما
+
+485
+00:49:05,640 --> 00:49:09,800
+يبين عليه أي مرضه، مايكون فيه مشكلة فحسب طبيعة
+
+486
+00:49:09,800 --> 00:49:15,240
+الخلل، طبيعة الانتقال، طبيعة الارتباط البعض بنتج
+
+487
+00:49:15,240 --> 00:49:21,560
+عنه، راح نحكي على أمراض ومشاكل وأنواع من المشاكل
+
+488
+00:49:21,560 --> 00:49:27,480
+التالية بس بظل يعني أنا أظن الأسهل وفينا يعني في
+
+489
+00:49:27,480 --> 00:49:32,810
+أمراض كثيرةمشهورة أو واحدة الميزة إذا شاف مريض مثل
+
+490
+00:49:32,810 --> 00:49:35,910
+هذا النوع اللي هي الـNon-distinction اللي هي
+
+491
+00:49:35,910 --> 00:49:39,870
+الـAbnormal Chromosomal Segregation هذه
+
+492
+00:49:39,870 --> 00:49:50,710
+الـMechanisms واللي نتكلم عنه هي النوعية الأكبر أو
+
+493
+00:49:50,710 --> 00:49:54,190
+نوعية قطع الكرموزومات الأكبر اللي هي
+
+494
+00:49:54,190 --> 00:50:02,280
+الـChromosomal Anomaliesبذكر مرة ثانية تذكروا إنه
+
+495
+00:50:02,280 --> 00:50:06,920
+إحنا في تعاملنا مع الأمراض الوراثية لازم هيك أحطها
+
+496
+00:50:06,920 --> 00:50:11,900
+بين ثلاث أنواع يا إما إشي في الـ Chromosome كله
+
+497
+00:50:11,900 --> 00:50:17,980
+وهي اللي راح نتكلم عنه يا إما Mendelian اللي هي
+
+498
+00:50:17,980 --> 00:50:22,140
+Single Nucleotide Single Gene Single Protein
+
+499
+00:50:22,140 --> 00:50:30,400
+متخصصةإلى قواعد وصول ومبادئ وفي المجموعة الثالثة
+
+500
+00:50:30,400 --> 00:50:34,780
+اللي هي اللي بيسموها Polygenic اللي هي بتكون أكتر
+
+501
+00:50:34,780 --> 00:50:38,660
+من جين بيستخدمها وهنا اللي نحن نتكلم عنه
+
+502
+00:50:38,660 --> 00:50:44,820
+Epigenetic Control الـGenetic Imprinting المشعرات
+
+503
+00:50:44,820 --> 00:50:50,140
+الـDNA Methylation الـHistone Methylation الـMicro
+
+504
+00:50:50,140 --> 00:50:55,040
+RNA Anomalies أو Changesفيه لها Mechanisms كثيرة
+
+505
+00:50:55,040 --> 00:51:01,520
+تتدخّل بعدين تشترك إنه الخلل أو المختلاف تكون فيه
+
+506
+00:51:01,520 --> 00:51:07,260
+عدد كبير من الجينات بطريقة مختلفة تتحكم في وظيفة
+
+507
+00:51:07,260 --> 00:51:11,780
+الـChromosome أو وظيفة الـDNA أو وظيفة البروتينز
+
+508
+00:51:11,780 --> 00:51:15,160
+فاحنا اليوم والآن على الـChromosome الـAnonymous
+
+509
+00:51:15,160 --> 00:51:18,860
+المجموعة
+
+510
+00:51:18,860 --> 00:51:25,030
+الأولىاللي هو يعني دايماً مش غلط الواحد يتذكر اللي
+
+511
+00:51:25,030 --> 00:51:33,330
+هم الـDance اللي هم المهم الواحد يعرف فضية اللي هي
+
+512
+00:51:33,330 --> 00:51:38,790
+الـCommon things are common أشياء شائعة شائعة
+
+513
+00:51:38,790 --> 00:51:43,150
+وبالتالي يعني هو اللي لازم يقدر يميزها بسرعة
+
+514
+00:51:43,150 --> 00:51:50,520
+وينتبع عليها ويتعامل معاهاالـ Trisomy السانيات
+
+515
+00:51:50,520 --> 00:51:57,120
+الأنواع التانية 18 و13 اللي هي مثلًا Cryotic K-Sac
+
+516
+00:51:57,120 --> 00:52:02,000
+أو الـ Edwards Syndrome أضل واحد ثاني إلى ثاني
+
+517
+00:52:02,000 --> 00:52:10,350
+ثاني، لأ الوضع أسوأ بكتيرماشي، وكلهم بيعيشوش،
+
+518
+00:52:10,350 --> 00:52:14,750
+بيموتوا بسرعة، ولادات يعني بعد الولادة بسرعة وفيه
+
+519
+00:52:14,750 --> 00:52:17,770
+severe mental retardation، severe heart
+
+520
+00:52:17,770 --> 00:52:25,310
+malformation كذا، بتلاقي فيه مشاكل كبيرة الـ Down
+
+521
+00:52:25,310 --> 00:52:30,770
+Syndrome مشهور ومعروف لما كنت طالب كنا هيك نتحدى
+
+522
+00:52:30,770 --> 00:52:36,790
+بعضحتى الواحد يذكرها كنا نقول فيه 30 character
+
+523
+00:52:36,790 --> 00:52:42,690
+موجودة في الـ Down Syndrome فنتبهوا هنا Hypotonia
+
+524
+00:52:42,690 --> 00:52:47,670
+يعني الشدة
+
+525
+00:52:47,670 --> 00:52:55,130
+العضلات، قوة العضلات، فيها رخاوة يعني، فـHypotonia
+
+526
+00:52:55,130 --> 00:53:01,290
+Short Stature، الطول القصير، Loose Skinon the
+
+527
+00:53:01,290 --> 00:53:07,610
+nape، اللي هو يعني على ال .. يعني في أسفل الظهر أو
+
+528
+00:53:07,610 --> 00:53:12,410
+في أسفل الرقبة الـ Palmer crease، احنا الأيديان
+
+529
+00:53:12,410 --> 00:53:16,130
+الواحدة دي كده بتطلع عليها فيه الفنتان اللي تشوفه
+
+530
+00:53:16,130 --> 00:53:20,350
+واحد عنده Down Syndrome مثلها كخط واحد Palmer
+
+531
+00:53:20,350 --> 00:53:26,140
+crease وclinodectin فيه خلل في الأصابعالـ Flat
+
+532
+00:53:26,140 --> 00:53:36,020
+Octopus يعني المؤخرة الرأس مش مستديرة هيك مسطحة
+
+533
+00:53:36,020 --> 00:53:40,960
+الـ Picantal Folds اللي هي كما بيقولوا منغولية
+
+534
+00:53:40,960 --> 00:53:46,240
+يعني شبيهة بعيون المغولة والصينيين وGokul اللي هي
+
+535
+00:53:46,240 --> 00:53:52,550
+حقيقة في الـmedial aspect of the eyeبتلاقي في الـ…
+
+536
+00:53:52,550 --> 00:53:58,370
+في الـ… يعني fold بطريقة معينة هي اللي بتعطي
+
+537
+00:53:58,370 --> 00:54:03,570
+العيون زي الصينيين يعني الـBrush field spots حاطين
+
+538
+00:54:03,570 --> 00:54:08,150
+صورة لها في moderate to mild أحيانًا severe
+
+539
+00:54:08,150 --> 00:54:13,050
+intellectual disability التخلف عقليcongenital
+
+540
+00:54:13,050 --> 00:54:18,470
+heart diseases «ديودنال أدريزيا» يعني اختلالات
+
+541
+00:54:18,470 --> 00:54:26,870
+القلب التركيبية أو المشاكل للقلب تسكيرة الأتناشر
+
+542
+00:54:26,870 --> 00:54:33,610
+احتمالية أكبر للسرطانات احتمالية أكبر للتخلف
+
+543
+00:54:33,610 --> 00:54:41,850
+العقلي الآن باستراحة يعني ميزة الـاللي عندهم Down
+
+544
+00:54:41,850 --> 00:54:48,810
+Syndrome حقيقةً، يعني تذكر دائماً عنهم إنهم عندهم
+
+545
+00:54:48,810 --> 00:54:55,230
+pleasant personality يعني شخصيتهم لطيطة، حبابين،
+
+546
+00:54:55,230 --> 00:55:02,910
+بنحبهم، حلوين، تعاملهم يعني حلو يعني والـLife
+
+547
+00:55:02,910 --> 00:55:10,750
+expectancy 555 يعني هذه باعتبر أنا دائماًإن الواحد
+
+548
+00:55:10,750 --> 00:55:17,290
+يتذكر مثل هذه الحالة هي موجودة ومتواجدة أو تقريبًا
+
+549
+00:55:17,290 --> 00:55:25,670
+واحد في 850 ألف حالة يعني تقريبًا أقل من واحد في
+
+550
+00:55:25,670 --> 00:55:30,650
+الألف أكتر شوية من واحد في الألف واحد في 850 بتوقع
+
+551
+00:55:30,650 --> 00:55:36,070
+يكون عنده Down Syndrome فيعني
+
+552
+00:55:36,070 --> 00:55:41,210
+أدولة جزء من المجتمعبيدوني واحد يحن عليهم و .. بس
+
+553
+00:55:41,210 --> 00:55:44,750
+أنا بظن يعني من الأجمل الأشياء أنهم لطيفين يعني
+
+554
+00:55:44,750 --> 00:55:49,350
+آه، في أسئلة؟
+
+555
+00:55:49,350 --> 00:55:57,530
+فإذا في حد عنده سؤال، يسأل الملاحظة الأهم أو مهمة
+
+556
+00:55:57,530 --> 00:56:04,330
+كثير فضية أنه الـ Down Syndrome أحيانًا كثيرة
+
+557
+00:56:04,330 --> 00:56:05,910
+مرتبط بعمر الأمة
+
+558
+00:56:08,570 --> 00:56:14,390
+إذا بالذات الأم عمرها أكتر من الأربعين سنة نسبة
+
+559
+00:56:14,390 --> 00:56:19,850
+حدوث الـDownward Neuron ترتفع بنسبة عالية جداً
+
+560
+00:56:19,850 --> 00:56:24,810
+يعني هنا الطريقتين
+
+561
+00:56:24,810 --> 00:56:30,350
+للدراسة في البدل الأمنيوسي أو اللي هو أخذ سائل
+
+562
+00:56:30,350 --> 00:56:35,030
+حواليه من الجنين أو الإنتظار الميراثي يعني هذه
+
+563
+00:56:35,030 --> 00:56:39,630
+طريقة من الدراسات للأسف في دول تانيةباعتبره إنه
+
+564
+00:56:39,630 --> 00:56:47,510
+فحص للـ DNA أو لقى مرض معين في ذات الحمل إنه
+
+565
+00:56:47,510 --> 00:56:54,270
+بيعرضوا الإجهاض حتى ما يطلع الطفل عنده صابة بأساس
+
+566
+00:56:54,270 --> 00:56:57,730
+باعتبره إنه في نهاية جوانب أخلاقية في الطب
+
+567
+00:56:57,730 --> 00:57:04,030
+وأخلاقية في التعامل مع الحياة وكذا لأن احنا
+
+568
+00:57:04,030 --> 00:57:08,390
+تقريبًا يعني في كلام على إنه قبلنفوخ، يعني ذاك
+
+569
+00:57:08,390 --> 00:57:13,390
+الروح اللي هو تقريبًا 120 يوم يعني فيه شوية خلاف
+
+570
+00:57:13,390 --> 00:57:17,650
+بين الفقهاء والعلماء ممكن الواحد يعرض الإجهاض
+
+571
+00:57:17,650 --> 00:57:24,390
+وممكن يعني بما أنه لسه مش كائن
+
+572
+00:57:24,390 --> 00:57:29,990
+أو مش إنسان مكتمل يعني فالفكرة يعني، بس النقطة
+
+573
+00:57:29,990 --> 00:57:37,000
+الأساسية أنه إذا كبر عمره الأم، نسبةالـ Down
+
+574
+00:57:37,000 --> 00:57:42,600
+Syndrome تكبر كثير ماشي وخصوصًا فوق سن الأربعين
+
+575
+00:57:42,600 --> 00:57:49,520
+يعني هو نقع تكون كبير كثير عادى، فهذه ناحية ناحية
+
+576
+00:57:49,520 --> 00:57:55,780
+ثانية يعني من الأشياء اللي الواحد بده ينتبهلها أن
+
+577
+00:57:55,780 --> 00:58:00,920
+أحيانًا الـ Trisomy 21 مافيكونش في كل الخلايا،
+
+578
+00:58:00,920 --> 00:58:05,460
+تكون في نسب من الخلايا والمقصود أنهالـ Non
+
+579
+00:58:05,460 --> 00:58:12,180
+-disjunction هذا اللي صار يعني مش على مستوى الـ
+
+580
+00:58:12,180 --> 00:58:16,860
+Egg و الـ Sperm بحيث إنه واحد منهم بيكون فيه
+
+581
+00:58:16,860 --> 00:58:21,120
+المشكلة لو بالـ Egg و الـ Sperm الأصليات كل
+
+582
+00:58:21,120 --> 00:58:24,720
+الخلايا اللي راح تطلع راح تكون فيها مشاكل بس لو
+
+583
+00:58:24,720 --> 00:58:28,660
+صار Non-disjunction بعدين يعني بعد ما صارت
+
+584
+00:58:28,660 --> 00:58:34,500
+Fertilized Egg وانقسمت مثلا مرتين، تلاتةفصار عندي
+
+585
+00:58:34,500 --> 00:58:39,140
+مثلًا 16 خلية واحدة منهم هي اللي صار فيها Non
+
+586
+00:58:39,140 --> 00:58:44,000
+-disjunction في حتة إنه صارت فيها Trisomy 21 في
+
+587
+00:58:44,000 --> 00:58:48,460
+واحدة منهم في حتة إنه بنتج عن هذا الأمر إنه راح
+
+588
+00:58:48,460 --> 00:58:55,120
+يكون إنه نسبة يعني ربع الخلايا تلت الخلايا 60% من
+
+589
+00:58:55,120 --> 00:58:59,960
+الخلايا اللي فيها الخلل والبقية طبيعية في تفاوت،
+
+590
+00:58:59,960 --> 00:59:09,760
+يعني في درجاتفهي طبيعة مهمة هنا الـ Rough Spots
+
+591
+00:59:09,760 --> 00:59:13,600
+الـ Brush Field Spots هنا حاطين كيف شكل العين يعني
+
+592
+00:59:13,600 --> 00:59:17,840
+فاهرة معينة وهي الـ Epicanthic Fold اللي هي للجوا
+
+593
+00:59:17,840 --> 00:59:25,200
+و Big Tongue و Pleasant Personality ويعني هاي اللي
+
+594
+00:59:25,200 --> 00:59:31,370
+هو Down Syndrome من أشياء الأمراض الكرمزوميةاللي
+
+595
+00:59:31,370 --> 00:59:37,430
+هي في المجتمع الـ
+
+596
+00:59:37,430 --> 00:59:48,290
+في هناك يعني أحيانًا حتى لو أنا مش كعدد ك band
+
+597
+00:59:48,290 --> 00:59:51,810
+وعدد ممكن ألاقي في
+
+598
+00:59:56,860 --> 01:00:04,460
+يعني أحيانًا مظهريًا بكون إنسان شكله لما نعمله
+
+599
+01:00:04,460 --> 01:00:09,540
+Carrier-type لما أدققتش كثير ولكن بالأول إنه بس في
+
+600
+01:00:09,540 --> 01:00:17,120
+نسختين من الـChromosome 21 فبظن إن التشفيذ غلط أو
+
+601
+01:00:17,120 --> 01:00:24,080
+بقول إنه فيه مشكلة بكون إنه الـChromosome 21 كما
+
+602
+01:00:24,080 --> 01:00:30,060
+هو في الصورة هذهراكب نسخة منه على كروموزوم 14 كبير
+
+603
+01:00:30,060 --> 01:00:37,820
+كروموزوم 14 وبالتالي أحيانًا الـ… الـ… يعني هنا
+
+604
+01:00:37,820 --> 01:00:41,940
+إحنا حاطين مثال إنه أنا المفروض بشكل طبيعي أكون
+
+605
+01:00:41,940 --> 01:00:48,480
+عند كروموزوم 14 وكروموزوم 21 منفصلات بهذا الشكل
+
+606
+01:00:48,480 --> 01:00:55,160
+إذا في عندي Balance Translocation بهذا الشكل إنه
+
+607
+01:00:55,460 --> 01:00:59,060
+الـ Chromosome 21 اللي هو أنه أصغر واحد ومطرد هيكي
+
+608
+01:00:59,060 --> 01:01:03,800
+وصغير لذب كله بالغلط مع Chromosome 14 وظلوا
+
+609
+01:01:03,800 --> 01:01:10,120
+موجودين هناك فإذا إنسان خلايا بهذا الشكل برضه هذا
+
+610
+01:01:10,120 --> 01:01:15,700
+ماعنديهوش مشكلة إذا كانت بشكل مختلف بهذه الأشياء
+
+611
+01:01:15,700 --> 01:01:20,360
+بتكون الأمور Unbalanced وبتروح تكون فيها مشاكل
+
+612
+01:01:20,360 --> 01:01:27,290
+مختلفة كبيرةهنا راح يكون down لأنه فيه زيادة طبعاً
+
+613
+01:01:27,290 --> 01:01:31,310
+هاي one copy وفيه copies تانية زيها فبنتج عن هذا
+
+614
+01:01:31,310 --> 01:01:35,210
+الأمر الثاني اللي نفترضها راح تكون طبيعية راح يكون
+
+615
+01:01:35,210 --> 01:01:40,570
+أنه عندي ثلاثة أو هنا فيه فقد تام لل 21 هنا في
+
+616
+01:01:40,570 --> 01:01:47,460
+عندي ثلاثة copy من ال chromosome 14 حتىهنا عندي
+
+617
+01:01:47,460 --> 01:01:51,980
+نصفة واحدة بس يعني كل هدولة راح يسببوا إشكالات
+
+618
+01:01:51,980 --> 01:02:00,080
+وأمراض ويكون مشاكل اللي
+
+619
+01:02:00,080 --> 01:02:09,580
+لان النقطة الأولى اللي ذكرناها عن أمراض اليوم أو
+
+620
+01:02:09,580 --> 01:02:16,000
+حالات اليوم أنه بنحكي عن الـ Chromosome فحكينا عن
+
+621
+01:02:16,000 --> 01:02:21,300
+الـ Autosomal Chromosomes وبالذات Chromosome 21
+
+622
+01:02:21,300 --> 01:02:27,740
+وخلّينا هاي شو اسمه، هاي اللي نذكرها راح ناخد بعد
+
+623
+01:02:27,740 --> 01:02:31,980
+شوية على الـ Six Chromosomes وشو بيصير بيهم فرح
+
+624
+01:02:31,980 --> 01:02:37,320
+نرجع لموضوع كـ Chromosome كامل بعد شوية الآن فيه
+
+625
+01:02:37,320 --> 01:02:45,880
+ظواهر وأمراض نتيجة يعني قطعة مشالـ Chromosome كامل
+
+626
+01:02:45,880 --> 01:02:53,000
+فمن الأشياء اللي أنا يعني بصراحة الـ Down Syndrome
+
+627
+01:02:53,000 --> 01:02:59,940
+شوفتالأنواع التانية للـ Autosome الـ 313، الـ 318،
+
+628
+01:02:59,940 --> 01:03:04,700
+الـ 360، ما عمري شوفت ويمكن الواحد بيكون
+
+629
+01:03:04,700 --> 01:03:11,320
+Neonatologist يشوف الـ Abortion ويعمل، يشوف شو
+
+630
+01:03:11,320 --> 01:03:18,920
+بيصير يعني في الموليد الجددالحديثي الولادة إذا ما
+
+631
+01:03:18,920 --> 01:03:23,420
+كان الواحد هذا تخصصه يمكن احتمال نادر أن يشوف
+
+632
+01:03:23,420 --> 01:03:29,840
+الأمراض اللي بنحكي عنها ماشي ال أنا بالنسبة لي
+
+633
+01:03:29,840 --> 01:03:35,740
+كمناعة وحساسية بهمني حالة اسمها Die George
+
+634
+01:03:35,740 --> 01:03:44,180
+Syndrome نخبركم عنها ويعني من كل هالالأمراض
+
+635
+01:03:44,180 --> 01:03:50,000
+والمشاكل وكذا أنا ماشوفتش الأنواع التانية و… بس
+
+636
+01:03:50,000 --> 01:03:57,460
+خلّينا عشان يعني يعني أنا بقول لوحدي لما يكون إن
+
+637
+01:03:57,460 --> 01:04:01,560
+شاء الله عنده المراجع وعنده ممكنية التواصل معاها
+
+638
+01:04:01,560 --> 01:04:06,880
+بالـ PubMed ولا الـ Online Mendelian Resource
+
+639
+01:04:06,880 --> 01:04:12,920
+لأسماء الأمراض الوراثية وكدهبكون إن شاء الله أموره
+
+640
+01:04:12,920 --> 01:04:17,860
+كويسة الـ Diehard Syndrome من أيام ما كنت طالب
+
+641
+01:04:17,860 --> 01:04:25,140
+يدرسوني إياه و هو من أحد أمراض مقصان المناعة و فيه
+
+642
+01:04:25,140 --> 01:04:31,780
+له مشكاك الكثير و يعني كنت محبوب لقبل أربع سنين
+
+643
+01:04:31,780 --> 01:04:36,740
+يعني بعد ما أجزت و شابل واحد لحظة أني شفت حالة
+
+644
+01:04:36,740 --> 01:04:43,610
+واحدة في حياتي هي شغلاتعبارة عن حالات نادرة
+
+645
+01:04:43,610 --> 01:04:53,010
+والواحد يعني بده يكون عنده قدرة على إنه يعني لما
+
+646
+01:04:53,010 --> 01:04:59,610
+نشوفها ويشك في إنها موجودة يعرف يطلب الفحص المناسب
+
+647
+01:04:59,610 --> 01:05:06,340
+حتى ألاقي هذه الشغلوأشوف أنه يعني أقدر أشخصها
+
+648
+01:05:06,340 --> 01:05:10,800
+ويكون عندي حتى فكرة شو الـ mechanism كان أنه صارت
+
+649
+01:05:10,800 --> 01:05:15,280
+وين الـ translocation وين الـ الـ كانت balanced،
+
+650
+01:05:15,280 --> 01:05:20,160
+unbalanced، شو صارت وكده الـ Dijard Syndrome،
+
+651
+01:05:20,160 --> 01:05:28,560
+ماشي، الآن احنا يعني we mapped it to chromosome 22
+
+652
+01:05:30,240 --> 01:05:36,900
+الـ «Q» اللي هو الـ «Long Arm» تبعته الـ «Band 11
+
+653
+01:05:36,900 --> 01:05:44,860
+.2» هو بتصير عملية «Deletion» يعني في إزالة لقطعة
+
+654
+01:05:44,860 --> 01:05:52,620
+صغيرة من الـ «DNA» يعني بالضبط كام «Gen»
+
+655
+01:05:52,620 --> 01:05:58,520
+موجود فيها بطيرًا عشان يستعطينا البرض هذا ما بعرف
+
+656
+01:05:58,520 --> 01:06:05,820
+100%فالـ Diehard Syndrome يعني إيه له قصص هيك
+
+657
+01:06:05,820 --> 01:06:12,760
+بعرفتها والواحد بيحكيها الـ Diehard Syndrome عبارة
+
+658
+01:06:12,760 --> 01:06:18,580
+عن لما يصير الـ deletion لهذا القطع من الـ DNA،
+
+659
+01:06:18,580 --> 01:06:24,680
+ماشي، بيصير عندي anomaly في الـ development تبعت
+
+660
+01:06:24,680 --> 01:06:28,650
+الـ third والfour pharyngeal pouchesفي الـ
+
+661
+01:06:28,650 --> 01:06:33,650
+Emperogenesis يعني إذا تتذكروا الـ Emperogenesis
+
+662
+01:06:33,650 --> 01:06:38,770
+اللي هي بالذات three to four pharyngeal pouches
+
+663
+01:06:38,770 --> 01:06:44,550
+بتكون في لحظة معينة زي ما إحنا بالقرآن الكريم نقول
+
+664
+01:06:44,550 --> 01:06:50,610
+إن الجنين على شكل المضغة المضغة يعني زي قطعة البن
+
+665
+01:06:50,610 --> 01:06:57,050
+على الكواكس شديتها ويكون عليها الـ pharyngeal
+
+666
+01:06:57,050 --> 01:07:01,820
+pouchesفبتطير أو بيصير خلل في الـ third والـ
+
+667
+01:07:01,820 --> 01:07:05,620
+fourth pharyngeal pouches أتأمل أنكم أخدتم الـ
+
+668
+01:07:05,620 --> 01:07:10,820
+embryology نتيجة هذا الخلل بيصير عندي ثلاث مظاهر
+
+669
+01:07:10,820 --> 01:07:15,820
+رئيسية الـ third والـ fourth pharyngeal pouches
+
+670
+01:07:15,820 --> 01:07:23,000
+بيكون فيهملأن هم راح يعطي الـ Thymus أو الغد الـ
+
+671
+01:07:23,000 --> 01:07:29,900
+2T اللي هي تبعت المناعة اللي في الصدر المنطقة
+
+672
+01:07:29,900 --> 01:07:34,640
+الأمامية من الصدر فبصير عندي Absent Thymus والـ
+
+673
+01:07:34,640 --> 01:07:38,020
+Thymus ضرورية للـ Development للـ T-cells في
+
+674
+01:07:38,020 --> 01:07:44,280
+المناعة هي بتتعلم، هي تتكون، هي تتنشط الـ Thymus
+
+675
+01:07:44,280 --> 01:07:47,880
+فبصير عندي Absence of T-cells وبالتالي عندي Immune
+
+676
+01:07:47,880 --> 01:07:52,100
+Deficiencyبيصير عنده Immune Deficiency الوظيفة
+
+677
+01:07:52,100 --> 01:07:55,480
+الثانية للـthird والـfourth pharyngeal pouches إن
+
+678
+01:07:55,480 --> 01:07:59,780
+هي بتشترك في الـroot of the heart في الـmajor
+
+679
+01:07:59,780 --> 01:08:04,100
+blood vessels فالـmajor blood vessels الأورطة
+
+680
+01:08:04,100 --> 01:08:08,460
+والبلمونري آرتي والـtruncus arteriosus والأشياء
+
+681
+01:08:08,460 --> 01:08:12,920
+هذه بتصير فيها خلب فبيصير عندي congenital heart
+
+682
+01:08:12,920 --> 01:08:18,160
+disease بيصير عندي مرض قلب خلقي عيب خلقي في القلب
+
+683
+01:08:18,920 --> 01:08:22,020
+الشغل الثالث اللي بتكون نتيجة الـ «تيرد» والـ
+
+684
+01:08:22,020 --> 01:08:28,480
+«بورت» الـ «ترنجيال باوتش» اللي هم الـ الـ الـ الـ
+
+685
+01:08:28,480 --> 01:08:33,540
+Parathyroid glands والـ Parathyroid glands أهميتهم
+
+686
+01:08:33,540 --> 01:08:37,200
+بالتحكم في الـ «ميتابوليزم» تبع الـ «كالسيو» فبصير
+
+687
+01:08:37,200 --> 01:08:42,220
+عندي مشكلة «هيبوكالسينيا» و«تيتاني» بصير الجنين أو
+
+688
+01:08:42,220 --> 01:08:46,920
+الـ أو الجنين يعني الـ «نيو بورن» بصير عنده تشلجات
+
+689
+01:08:46,920 --> 01:08:51,020
+و«تيتاني»وفيكون نتيجة الـHypocalcemia بسبب
+
+690
+01:08:51,020 --> 01:08:57,780
+الـHypoparathyroidism فالـVelio
+
+691
+01:08:57,780 --> 01:09:01,880
+-below-cardiofacial syndrome أي الإسم التاني
+
+692
+01:09:01,880 --> 01:09:06,680
+للـDijord Syndrome يكون عندي مشاكل في القلب، مشاكل
+
+693
+01:09:06,680 --> 01:09:11,160
+في الـThymus وفي المناعة ومشاكل في الـCalcium وفي
+
+694
+01:09:11,160 --> 01:09:16,360
+الـMetabolism تبع الـHypoparathyroidism
+
+695
+01:09:17,070 --> 01:09:22,250
+النقطة الأخيرة فيهم اللي هي قضية إنه راح يكون
+
+696
+01:09:22,250 --> 01:09:28,630
+بيسموها «Dysmorphic Features» الحاطين هنا أظن صور
+
+697
+01:09:28,630 --> 01:09:32,250
+اللي
+
+698
+01:09:32,250 --> 01:09:38,210
+هم الـ «Trisomy 21» خلّيني أشوف، لأ مش حاطين
+
+699
+01:09:38,210 --> 01:09:41,870
+«Dijord Syndrome» بيبسوه، بيكون بيسموها «Loss of
+
+700
+01:09:41,870 --> 01:09:50,300
+ears»يعني الـ… الـ… لما الواحد يشوف الجنين الأصل
+
+701
+01:09:50,300 --> 01:09:54,180
+في الإنسان إذا الواحد انتبه على حاله إنه ديناي
+
+702
+01:09:54,180 --> 01:09:57,820
+بيكونوا على مستوى العين يعني إذا أخدت خط بين
+
+703
+01:09:57,820 --> 01:10:02,380
+الآنتين الدينان تقريباً هنا إذا دينان الواحد أنزل
+
+704
+01:10:02,380 --> 01:10:07,080
+من هذا الوضع يسموها «loss of ear» يكون «increased
+
+705
+01:10:07,080 --> 01:10:11,340
+philtrum» اللي هي المسافة بين الأمك والشفة العلية
+
+706
+01:10:11,880 --> 01:10:16,560
+اللي كونها شكلها «increase» فإنهم شكل مميز يعني
+
+707
+01:10:16,560 --> 01:10:24,000
+فهذا إيش اسمه «Digest Syndrome» فبقية الـ
+
+708
+01:10:24,000 --> 01:10:29,920
+«diseases» بدّيش يعني الفكرة فيها مراد كثيرة وهي
+
+709
+01:10:29,920 --> 01:10:36,100
+«list of examples» يعني هذولة نسبة أو يعني عدد
+
+710
+01:10:36,100 --> 01:10:42,400
+محدود من الأمثلةوإنه في عندي أمراض كثيرة أخرى
+
+711
+01:10:42,400 --> 01:10:48,580
+بيكون أنا المشكلة عندي هي segmental deletion أو
+
+712
+01:10:48,580 --> 01:10:53,560
+duplication يعني عبارة عن قطعة مش الـ…
+
+713
+01:10:53,560 --> 01:11:00,120
+الـChromosome كامل، ماشي؟ فهذه أشياء بتحدث وموجودة
+
+714
+01:11:00,120 --> 01:11:08,040
+في الطبيعة، موجودة في الحياةموجودة ومؤثرة والواحد
+
+715
+01:11:08,040 --> 01:11:15,160
+تطفت عنده حالة بده يحسن التنقيب والبحث عن من
+
+716
+01:11:15,160 --> 01:11:21,760
+المراجع العلمية المعتمدة الـ Online Databases زي
+
+717
+01:11:21,760 --> 01:11:27,190
+ما بقوله، قواعد البيانات على الـNetبحيث إنه يدخل
+
+718
+01:11:27,190 --> 01:11:31,630
+كل المعلومات اللي بعرفها كمظاهر ويحاول يلاقي منها
+
+719
+01:11:31,630 --> 01:11:39,170
+شو التشخيص أو وين العلة عشان يختار بعدين الـTest
+
+720
+01:11:39,170 --> 01:11:42,370
+المناسب حتى يثبت إن هذا الموضوع موجود
+
+721
+01:11:42,370 --> 01:11:46,910
+فالـRearrangement
+
+722
+01:11:46,910 --> 01:11:52,770
+لقضية اللي يصير Deletion أو Duplication أثنانهم
+
+723
+01:11:52,770 --> 01:11:58,920
+لنفس الـMechanism لما نكونعندي سواء إذا كامل، Non
+
+724
+01:11:58,920 --> 01:12:02,920
+-distinction يعني بتكون أثنين مع بعض بيروحوا هيك
+
+725
+01:12:02,920 --> 01:12:07,720
+أو صفر بيروح الجهة الثانية، بتكون كاملة بس أحياناً
+
+726
+01:12:07,720 --> 01:12:13,160
+بتكون على قطعة وبتكون إنه إشي بنتقل من محل لمحل
+
+727
+01:12:13,160 --> 01:12:18,220
+ثاني فبنتج عنه إنه في نسخة راح تكون Duplication
+
+728
+01:12:18,220 --> 01:12:23,440
+وفي نسخة تانية أو جهة تانية راح يكون فيه Deletion
+
+729
+01:12:23,440 --> 01:12:32,240
+فهي لنفس الـMechanismهنا برضه يعني هاي هون اللي
+
+730
+01:12:32,240 --> 01:12:37,460
+عملنا عن طريق الـ Karyotype على Binding دورت على
+
+731
+01:12:37,460 --> 01:12:45,080
+إشي معين ممكن أنا هنا الـ Fish كأسلوب أدور على
+
+732
+01:12:45,730 --> 01:12:53,610
+بطريقة معينة عليهم وبعدين في عندي اللي هو micro
+
+733
+01:12:53,610 --> 01:12:59,850
+arrays بتكون أنا ممكن أدور بطريقة معينة وبعدين
+
+734
+01:12:59,850 --> 01:13:10,590
+بروح أقراها ويعني بتكون عندي، شو اسمه؟ محاضرة أنا،
+
+735
+01:13:10,590 --> 01:13:11,610
+محاضرة، محاضرة
+
+736
+01:13:14,980 --> 01:13:23,480
+فأسف، يعني هذه الأليات المختلفة لمعرفة النوع
+
+737
+01:13:23,480 --> 01:13:30,080
+التاني من الـChromosome Anomalies يعني هنا
+
+738
+01:13:30,080 --> 01:13:36,060
+كـChromosome كامل، فيه عدد محدودكقطع من
+
+739
+01:13:36,060 --> 01:13:41,140
+الكرموزومات، فيه برضه نسبة موجودة، هناك أنفل عليها
+
+740
+01:13:41,140 --> 01:13:46,880
+دخلنا على قصة الـDijort Syndrome كمثال، مديش غيره،
+
+741
+01:13:46,880 --> 01:13:56,600
+بس الفكرة إنه بكون في عندي يعني مظاهر متعددة وانا
+
+742
+01:13:56,600 --> 01:14:00,060
+بإمكاني أدرسها بطرق مختلفة
+
+743
+01:14:03,080 --> 01:14:07,620
+في حاجة اسمها «Brother Willy Engelman Syndromes»
+
+744
+01:14:07,620 --> 01:14:12,700
+كانوا حاطين صورهم بهذا الشكل، ماشي، رخاوة في
+
+745
+01:14:12,700 --> 01:14:20,420
+العضلات، تخلف عقلي، أمراض، مشاكل ثانية، إذا الواحد
+
+746
+01:14:20,420 --> 01:14:27,520
+بدي ياخد خط الطب كـPediatrician، كـGeneticist أو
+
+747
+01:14:27,520 --> 01:14:30,340
+كذا، بدي يصير يعرف عنهم ويتعامل معهم
+
+748
+01:14:34,340 --> 01:14:38,860
+الآن الجانب الأخير من الأمراض الكرمزومية اللي هو
+
+749
+01:14:38,860 --> 01:14:43,220
+الـ Sex Chromosomes الـ Sex Chromosomes يعني ناحية
+
+750
+01:14:43,220 --> 01:14:52,960
+مهمة كثير ويعني بدها تكون نابع للواحد من فهم ضروري
+
+751
+01:14:52,960 --> 01:15:02,380
+للمبادئ تبعتها بالنسبة للـ Sex Development وتطور
+
+752
+01:15:02,380 --> 01:15:12,050
+الإنسان الجنسيبنلاقي أنا عندى بتكلم عن ثلاث
+
+753
+01:15:12,050 --> 01:15:20,710
+مستويات من المظاهر وأحياناً طبعاً في الغالب بتكون
+
+754
+01:15:20,710 --> 01:15:27,830
+بطرق معينة بس هناك طرق متعددة للاختلالات فالأصل
+
+755
+01:15:27,830 --> 01:15:33,850
+الإنسان الرجل الذكر بكون عنده X Y chromosome
+
+756
+01:15:35,940 --> 01:15:44,340
+التركيب للـ «جونات» أو العضاء التناثولية تبعته إنه
+
+757
+01:15:44,340 --> 01:15:51,480
+عنده خصي أو Testiclesماشي، وبالأخير تعطي مظاهر
+
+758
+01:15:51,480 --> 01:15:59,640
+اللي نرضقها بالدكورة يعني الصوت أجش الشعر في
+
+759
+01:15:59,640 --> 01:16:04,500
+اللحية وفي مناطق معينة في الجسم كمية العضلات في
+
+760
+01:16:04,500 --> 01:16:10,920
+جسمه أكبر الهرمونات في منصة جسمه تكون مختلفة هذه
+
+761
+01:16:10,920 --> 01:16:15,040
+اللي بيسميها مظاهر الدكورة أو الأنوثة الـ
+
+762
+01:16:15,040 --> 01:16:23,940
+Phenotypeالـ Phenotype هذا هو نتيجة أول شيء جزء
+
+763
+01:16:23,940 --> 01:16:28,840
+منه الكروموزومات وما ينتج عنها منه بروتينات وما
+
+764
+01:16:28,840 --> 01:16:35,520
+ينتج عنها منه تراكيب ثم بعد ذلك جوانب هرمونية
+
+765
+01:16:35,520 --> 01:16:41,980
+نتيجة الـ Gonads وبعد ذلك الصراحة الجوانب
+
+766
+01:16:41,980 --> 01:16:49,870
+المجتمعيةيعني الـ role-playing يعني المجتمع عادة
+
+767
+01:16:49,870 --> 01:16:56,750
+الطفل من صغره إذا كان ذكر بيصيروا يقولوا أنت زلمة
+
+768
+01:16:56,750 --> 01:17:01,570
+واش بتعيط زي البنات ولا بيصيروا ربوه على إنه يكون
+
+769
+01:17:01,570 --> 01:17:06,190
+خش إنه ما يشكيش وإنه كده وإنه كده كدا بتلاقي بواهر
+
+770
+01:17:06,190 --> 01:17:11,390
+حتى من ناحية المجتمع بتتدخل فيه شويه يعني مناسب
+
+771
+01:17:11,900 --> 01:17:17,960
+لأنه هذا رجل أو هي أنثى فبالمقابل
+
+772
+01:17:17,960 --> 01:17:23,060
+الـ Females في عندنا بيكون عندهم XX chromosomes
+
+773
+01:17:23,060 --> 01:17:30,740
+بتكون عندنا مبايض Ovaries وبعدين بيصير الشكل
+
+774
+01:17:30,740 --> 01:17:36,120
+المميز للـ Phenotype كـ Female تتدخل فيه أشياء
+
+775
+01:17:36,120 --> 01:17:40,060
+كتيرة الآن
+
+776
+01:17:40,470 --> 01:17:46,230
+الـ Y-Chromosome حقيقةً فيه عدد قليل من الجينات
+
+777
+01:17:46,230 --> 01:17:51,890
+حاطين هنا تفاصيل من أصغر الـChromosomes كمان زي
+
+778
+01:17:51,890 --> 01:17:57,070
+الـChromosome 21 قريب منه يعني في الحجم وبكون
+
+779
+01:17:57,070 --> 01:18:06,910
+مافيش فيه، إيش اسمه؟ مايكونش فيه يعني كبير عدد من
+
+780
+01:18:06,910 --> 01:18:12,010
+الـChromosomes اللي بتأثر علىأشياء محينة يعني،
+
+781
+01:18:12,010 --> 01:18:16,450
+ماشي، فياسلة؟
+
+782
+01:18:16,450 --> 01:18:19,650
+السلام
+
+783
+01:18:19,650 --> 01:18:23,250
+عليكم، فياسلة؟ تمام لحد الآن يا دكتور، تمام، مافي
+
+784
+01:18:23,250 --> 01:18:30,010
+سؤال يعني، طيب، الفهم لكيف تطور الدكور والإينات
+
+785
+01:18:30,590 --> 01:18:34,370
+وكيف ربنا حطم فينا هيك الأشياء وكيف ربنا خلقنا
+
+786
+01:18:34,370 --> 01:18:46,890
+صراحة فيه يعني أفضل تقويم ويعني كيف الإنسان بتخلق
+
+787
+01:18:46,890 --> 01:18:51,970
+حقيقة يعني عجبة من الله سبحانه وتعالى من الأشياء
+
+788
+01:18:51,970 --> 01:18:59,560
+اللي لازم تكونوا تتذكروها أولاً أنهفي الـ
+
+789
+01:18:59,560 --> 01:19:05,580
+Embryogenesis يعني في مرحلة تخلق الإنسان في مرحلة
+
+790
+01:19:05,580 --> 01:19:12,160
+الجنينية المبكرة ناشي الإنسان بيولد بالأول أو
+
+791
+01:19:12,160 --> 01:19:21,360
+بيتخلق بالأول وعنده تراكيب يعني ذكورة وأنوثة في
+
+792
+01:19:21,360 --> 01:19:28,560
+نفس الوقت ناشيفبقرا «ميزونفريك دكت» «ميزونفريك
+
+793
+01:19:28,560 --> 01:19:32,900
+دكت» «ميزونفريك
+
+794
+01:19:32,900 --> 01:19:38,400
+دكت» «ميزونفريك دكت» «ميزونفريك دكت» «ميزونفريك
+
+795
+01:19:38,400 --> 01:19:39,040
+دكت» «ميزونفريك دكت» «ميزونفريك دكت» «ميزونفريك
+
+796
+01:19:39,040 --> 01:19:39,520
+دكت» «ميزونفريك دكت» «ميزونفريك دكت» «ميزونفريك
+
+797
+01:19:39,520 --> 01:19:42,060
+دكت» «ميزونفريك دكت» «ميزونفريك دكت» «ميزونفريك
+
+798
+01:19:42,060 --> 01:19:50,260
+دكت» «ميزونفريك دكت» «ميزونفريك دكت» «ميزونفريك
+
+799
+01:19:50,260 --> 01:19:59,200
+دكت» «ميزيعني بيقولوا الـ Default يعني الإعداد
+
+800
+01:19:59,200 --> 01:20:06,700
+التلقائي الـ Default Development بتكون إنه الإنسان
+
+801
+01:20:06,700 --> 01:20:16,420
+بتحول إلى أنثى إذا فيه الـ Y-Chromosome ماشي بتحول
+
+802
+01:20:16,420 --> 01:20:23,340
+لدفع أما إذا مافيش Y-Chromosomeيعني وجود الـ X أو
+
+803
+01:20:23,340 --> 01:20:28,620
+أكثر من X أو عدد كبير من الـ X ما بيخلي الأنثى
+
+804
+01:20:28,620 --> 01:20:35,100
+تتكون عدم وجود الـ Y-Chromosome هو ما يدفع الـ
+
+805
+01:20:35,100 --> 01:20:41,560
+Development إلى قضية أن يكون الشخص هذا ذكر فوجود
+
+806
+01:20:41,560 --> 01:20:46,220
+الـ Y-Chromosome هو اللي بيصنع الـ Testes بيحول
+
+807
+01:20:46,220 --> 01:20:52,050
+إلى Testes وبيغير شكل القنواتبولية والقنوات
+
+808
+01:20:52,050 --> 01:20:58,390
+التناسلية بحيث إنه يعطي شكل الذكر في الـ Internal
+
+809
+01:20:58,390 --> 01:21:02,490
+والـ External Genitalia اللي هم الأعضاء التناسلية
+
+810
+01:21:02,490 --> 01:21:09,750
+الداخلية والقارجية البربخ والقنوات
+
+811
+01:21:09,750 --> 01:21:17,170
+تبعات الـ Sperms والبرستاتا
+
+812
+01:21:17,170 --> 01:21:25,120
+والذكر والأشياء هذهفي مقابل العدم موجود الـ Y
+
+813
+01:21:25,120 --> 01:21:28,740
+-Chromosome هو ما يدفع الـ Development إنه تتحول
+
+814
+01:21:28,740 --> 01:21:33,280
+باتجاه الأنثى وهي اللي بيسموها الـ Default يعني
+
+815
+01:21:33,280 --> 01:21:37,300
+هنا إذا مافيش أي مؤثر خارجي راح تمشي بهذا الطريق
+
+816
+01:21:37,300 --> 01:21:44,440
+فبتكون المبيض وبعدين قنوات Falloff وبعدين بقية
+
+817
+01:21:44,440 --> 01:21:50,190
+الرحم وقطعه وبعدين المهبل وغيرهالـ Female Internal
+
+818
+01:21:50,190 --> 01:21:56,510
+و External Genital ماشي فالإنسان
+
+819
+01:21:56,510 --> 01:22:06,270
+الطبيعي يعني عادة إذا ذكر XY إذا أنثى XX والأصل
+
+820
+01:22:06,270 --> 01:22:12,630
+يعني في التحكم إنه تروح باتجاه الذكر الذكورة هي
+
+821
+01:22:12,630 --> 01:22:19,880
+وجود الـXكثير من المظاهر مرتبطة بعد ما تتكون الـ
+
+822
+01:22:19,880 --> 01:22:24,280
+Testicles وتكون مصدر للهرمونات، الـTestosterone
+
+823
+01:22:24,280 --> 01:22:32,480
+وهو بيؤدي إلى إن المظاهر تتباع وتتغير وتكون بالشكل
+
+824
+01:22:32,480 --> 01:22:41,100
+اللي عندنا موجود فهي نواحي مهمة الآن في ظاهرة
+
+825
+01:22:41,100 --> 01:22:47,490
+حكينا عنها من قبلطبعًا الـ X-Chromosome أكبر بكثير
+
+826
+01:22:47,490 --> 01:22:52,690
+يعني الـ Chromosome محرز، كبير وفي عليه جينات
+
+827
+01:22:52,690 --> 01:22:57,790
+كثيرة وبلها دخل في أشياء كثيرة طبعًا أهم ميزة فيها
+
+828
+01:22:57,790 --> 01:23:02,670
+أو أهم مشكلة فيها أنه اللي لما يكون عندي نسخة
+
+829
+01:23:02,670 --> 01:23:08,730
+مريضة الـ Male راح يكون يأكل هوا لأنه لو نسخة
+
+830
+01:23:08,730 --> 01:23:13,390
+واحدة مافيش عنده مجال إذا بالذات Recessiveوهو يعني
+
+831
+01:23:13,390 --> 01:23:18,830
+صفة متنحية راح يكون إنها رغم إنها متنحية بس بتظهر
+
+832
+01:23:18,830 --> 01:23:25,990
+بالدكور فدايما يعني قضية الـ X-Chromosomes وأهميته
+
+833
+01:23:25,990 --> 01:23:32,510
+يعني شغل سبحان الله مهم كتير فلمّا
+
+834
+01:23:32,510 --> 01:23:39,330
+يكون الأنثى أو حتى لو ذكر مثلا XXY والـ XXY راح
+
+835
+01:23:39,330 --> 01:23:47,430
+يكون مظهريا إيش؟ ذكرلأنه عند الـY لما يكون XXY
+
+836
+01:23:47,430 --> 01:23:51,470
+الـTwo X دولة بيكونوا الشغالات أثنان وفي كل
+
+837
+01:23:51,470 --> 01:24:02,490
+الخلايا لو أنا بقدر أدرس بشكل عميق أنواع الـDNA
+
+838
+01:24:02,490 --> 01:24:08,510
+الشغال في كل خلية بلاقي إنه في حالة لما يكون عندي
+
+839
+01:24:08,510 --> 01:24:14,650
+أكتر من نسقة من الـXواحد منهم بس اللي شغالة فهنا
+
+840
+01:24:14,650 --> 01:24:18,870
+بيشرحوا Epigenetic وChromosomal Features و X
+
+841
+01:24:18,870 --> 01:24:23,070
+-Chromosome Inactivation in somatic cells ففي
+
+842
+01:24:23,070 --> 01:24:28,230
+الخلايا الجسمانية أي خلية صحيح أنها Two copies of
+
+843
+01:24:28,230 --> 01:24:34,290
+X-Chromosome بس واحدة بس منهم شغالة التانية بتكون
+
+844
+01:24:34,290 --> 01:24:41,480
+Silence وهذه الظاهرة بتحدث أولاًفي مرحلة مبكرة في
+
+845
+01:24:41,480 --> 01:24:46,920
+الـ Development بحيث إن مجموع الخلايا، نص الخلايا،
+
+846
+01:24:46,920 --> 01:24:51,600
+ربع الخلايا بتلاقي هذه الـ Copy هي الشغالة طبعاً
+
+847
+01:24:51,600 --> 01:24:55,760
+بتكون X-Chromosome أخذها الواحد مثلا أو أخذتها الـ
+
+848
+01:24:55,760 --> 01:25:02,070
+Female من والدها ومن والدتها، من الأب ومن الأمفإذا
+
+849
+01:25:02,070 --> 01:25:05,390
+بقدر أنا أفرّق إن هاي أجت من هون وهي أجت من هناك
+
+850
+01:25:05,390 --> 01:25:13,430
+بكون بلاقي في عندي واحدة بس هي لشغالة فالـ Gene
+
+851
+01:25:13,430 --> 01:25:20,590
+Expression الـ Active بكون هو اللي هو Active،
+
+852
+01:25:20,590 --> 01:25:28,210
+ماشي، الثاني Most Genes Are Silenced لحتى لما نقول
+
+853
+01:25:28,210 --> 01:25:31,780
+Silenceيعني هو أنا إذا عشان يحكوا التفاصيل أدق
+
+854
+01:25:31,780 --> 01:25:37,720
+شوية حوالي 15% are expressed to some degree يعني
+
+855
+01:25:37,720 --> 01:25:42,620
+حتى لما نقوله «inactive X-chromosome» مثلا في خلية
+
+856
+01:25:42,620 --> 01:25:47,460
+معينة مش كل الجينات على الـX-chromosome بتكون كلها
+
+857
+01:25:47,460 --> 01:25:54,420
+صفر وما بتشتغلش في نسبة قليلة بيكون، إيش هو اسمه؟
+
+858
+01:25:54,420 --> 01:25:58,020
+بيكون الـ«active»
+
+859
+01:26:00,510 --> 01:26:05,370
+لما أنا أدور على الـ DNA تبع الـ X-Chromosome في
+
+860
+01:26:05,370 --> 01:26:09,190
+هذه الحالة بكون على حالة الـ Euchromatin يعني
+
+861
+01:26:09,190 --> 01:26:18,510
+الكروماتين الحقيقي بمعنى إنه عبارة عن DNA مفروض مش
+
+862
+01:26:18,510 --> 01:26:24,130
+مضغوط وغير فاعل، لأ، مفروض ويتم استخدامه الـ
+
+863
+01:26:24,130 --> 01:26:28,910
+Inactive اللي هو اسمه الـ Bar Body، ماشياللي هو
+
+864
+01:26:28,910 --> 01:26:35,070
+يعني مضغوط ونايم وخارج طبعاً الـ «باربا» دي يعني
+
+865
+01:26:35,070 --> 01:26:42,210
+أنت بتعرفه جزء من بقصات التباتة الذكورة أو الأنوتة
+
+866
+01:26:42,210 --> 01:26:48,410
+أو كذا يعني لما نيجي نتكلم عن نفترض الألعاب
+
+867
+01:26:48,410 --> 01:26:54,920
+الأولومبية في واحدة أشطر ركيبة في الألعاب القوةصار
+
+868
+01:26:54,920 --> 01:27:01,420
+إن البنات التانية تقولوا لهذا زلمة مش أنثى
+
+869
+01:27:01,420 --> 01:27:08,060
+يعني، شايفين؟ فإذا الواحد باخد مسحة بسيطة من الحلق
+
+870
+01:27:08,060 --> 01:27:14,400
+وبروح بدور باستخدام الـChromatin وبيشوف Condensed
+
+871
+01:27:14,400 --> 01:27:20,360
+ولا لأ إذا فيه Bar Bodies بعرف إنه فيه X
+
+872
+01:27:20,360 --> 01:27:27,220
+-Chromosome، Inactiveفالحالة هذه يعني لو جيت أنا
+
+873
+01:27:27,220 --> 01:27:30,840
+وأنثى
+
+874
+01:27:30,840 --> 01:27:35,380
+مالكتش فيها ولا بعربة دي معناته هي مش أنثى حتى لو
+
+875
+01:27:35,380 --> 01:27:39,980
+مظهريًا وشكلًا بتبين كأنثى فهي بتحكي على أشياء
+
+876
+01:27:39,980 --> 01:27:44,560
+تانية فيه Non-Coding RNA اللي هو التفاصيل
+
+877
+01:27:44,560 --> 01:27:46,940
+والـHistone Variant اللي هو الـHistone
+
+878
+01:27:46,940 --> 01:27:48,860
+Modification اللي يعني
+
+879
+01:27:51,440 --> 01:27:56,600
+الـ Epigenetic Control من ناشب الكولوجيا أمثلة لـ
+
+880
+01:27:56,600 --> 01:28:07,500
+«So Far» بيحكوا عن محاولة فهم المرض وفهم الظاهرة
+
+881
+01:28:07,500 --> 01:28:12,320
+على أساس إن شاء الله بعدين يطلعون أدوية أو أساليب
+
+882
+01:28:12,320 --> 01:28:18,420
+تعديل أو أساليب علاج أو أدوية يعني هذه جزء من
+
+883
+01:28:18,420 --> 01:28:26,050
+التقدم العلمي الحالي إنهيحاولوا يدرسوها، فهذه الـ
+
+884
+01:28:26,050 --> 01:28:32,570
+Bar Bodies، ماشي، فهنا أمثلة، خلّينا نشوف الاتحاد،
+
+885
+01:28:32,570 --> 01:28:36,710
+وبعدين نطلع للدراسة، فهذه مثلا أنسة بختار
+
+886
+01:28:36,710 --> 01:28:44,370
+الطبيعية، واحد من الكروموزومات المفكوك وبيتم
+
+887
+01:28:44,370 --> 01:28:48,730
+استخدامه، وOne Bar Body، وهنا Two Bar Bodies،
+
+888
+01:28:48,730 --> 01:28:53,690
+Three Bar Bodies، Four Bar Bodies،يعني هاي عدد الـ
+
+889
+01:28:53,690 --> 01:29:02,090
+«كروموزومات» 49 وعندها X X X X X ناشي، تحدث، غادرة
+
+890
+01:29:02,090 --> 01:29:07,530
+جداً وإذا بدي أدور عليها يمكن ألاقيها وكذا بس يعني
+
+891
+01:29:07,530 --> 01:29:12,210
+الفكرة، انتبهوا هنا إنه دايماً سواء Male ولا
+
+892
+01:29:12,210 --> 01:29:16,870
+Female فيه one copy of X chromosome which is
+
+893
+01:29:16,870 --> 01:29:24,930
+activeاللي بيخلّي إنسان مهل هو الـ Y بغض النظر
+
+894
+01:29:24,930 --> 01:29:28,530
+يعني هو أنا حاطي نسخة أو نسختين أول مرة بشوف هيك
+
+895
+01:29:28,530 --> 01:29:37,710
+هي الـ XY-Chromosome أو XYY نفس الشيء أو XXY XXYY
+
+896
+01:29:37,710 --> 01:29:45,210
+يعني الدواهر الـ Non-disjunction دواهر عدم
+
+897
+01:29:45,210 --> 01:29:51,540
+الانفصال بين الـ X والـ Y-Chromosomeالـ Cell Cycle
+
+898
+01:29:51,540 --> 01:29:58,220
+أكثر من بقية الكرومزومات السبب إنه الواحد الكبير
+
+899
+01:29:58,220 --> 01:30:03,300
+وواحد صغير إنك تركّب اتنين واختلاف كبير في الحجم
+
+900
+01:30:03,300 --> 01:30:07,560
+بالبعض عشان ينفصلوا بشكل سليم هذا ما بيحدث
+
+901
+01:30:07,560 --> 01:30:15,160
+وبالتالي احتماليات الخلل أكبر فهيك أمثلة اسمها الـ
+
+902
+01:30:15,160 --> 01:30:21,280
+Bar Body اللي هو الـ Inactive X-Chromosomeوفي عنا
+
+903
+01:30:21,280 --> 01:30:26,340
+أمثلة على أحيانًا بتكون بهذا الشكل إن شاء الله
+
+904
+01:30:26,340 --> 01:30:34,880
+إنها واضحة بظن أنا صارت الساعة عشرة بنكمل إن شاء
+
+905
+01:30:34,880 --> 01:30:40,120
+الله يومبعد إذنك، يعني قبل ما تنهي، النقطة اللي
+
+906
+01:30:40,120 --> 01:30:43,520
+سأل عنها كريم بخصوص الـVariation في الـIndividual
+
+907
+01:30:43,520 --> 01:30:48,720
+Genomes يعني في .. مش عارف ايه، أظن أني موجود يا
+
+908
+01:30:48,720 --> 01:30:55,680
+كريم في Chapter رقم 4، صحيح؟ إذا بتسمعني كريم
+
+909
+01:30:55,680 --> 01:31:01,160
+Chapter رقم 4؟ آه، صحيح، موجود في Chapter رقم 4
+
+910
+01:31:01,160 --> 01:31:05,860
+آه، شو بدك؟ أنه واحدة؟النقطة الـ Variation في الـ
+
+911
+01:31:05,860 --> 01:31:10,140
+Individual Genomes يعني
+
+912
+01:31:10,140 --> 01:31:14,340
+إحنا كل المحاضرة عن إنه فيه Variation في الـ
+
+913
+01:31:14,340 --> 01:31:20,740
+Genome الـ Genome شو هو؟ الـ Genome هو مجمل المادة
+
+914
+01:31:20,740 --> 01:31:26,100
+الوراتية كلها لما نتكلم Genome يعني كل الـ DNA تبع
+
+915
+01:31:26,100 --> 01:31:32,880
+الكائن الإنساني هذا أو الإنسان هذا ففي عندي يعني
+
+916
+01:31:33,500 --> 01:31:39,160
+فأي نوع الـ Variation؟ هو له أنواع كثيرة لما يكون
+
+917
+01:31:39,160 --> 01:31:44,700
+يشوف اللي بحكي عنه يفرجيني يعني دكتور يعني خليني
+
+918
+01:31:44,700 --> 01:31:54,360
+أشاركلك الصورة اللي هو بعتلي إياها نعم، أه طيب،
+
+919
+01:31:54,360 --> 01:32:01,840
+أه، فرجيني الصورة
+
+920
+01:32:01,840 --> 01:32:07,200
+موجودة الآن هيهانعم إذا أنت شايفها؟ طيب، هسا هاي
+
+921
+01:32:07,200 --> 01:32:12,960
+نحكي عن حالة محددة اللي هي نوع من الـ Hemophilia
+
+922
+01:32:12,960 --> 01:32:20,020
+الـ Hemophilia اللي هو الـ Factor 8 تبع الـ
+
+923
+01:32:20,020 --> 01:32:26,100
+Clotting Factor تبع اللي بعمل تجلط الدم ماشي، دولة
+
+924
+01:32:26,100 --> 01:32:31,500
+موجودة على الـ X-Chromosome هسا اللي بيصير أحيانًا
+
+925
+01:32:31,770 --> 01:32:38,950
+ممكن مثلًا «Snip» أو «As if» «Deletion» «The One
+
+926
+01:32:38,950 --> 01:32:43,510
+Nucleotide» بيعمل «Frame Shift» بيخرّبلك كل
+
+927
+01:32:43,510 --> 01:32:49,830
+البروتين ويغلط الـ «DNA» يشغّل ماشي هنا ظاهرة
+
+928
+01:32:49,830 --> 01:32:56,970
+ثانية الظاهرة هذه إنه أنا في عندي قطعتين ممكن
+
+929
+01:32:56,970 --> 01:33:04,040
+هذولة يلبجوا على بعضفلمّا اللي هي ما بين النقطة A
+
+930
+01:33:04,040 --> 01:33:12,000
+والنقطة B فالأصل الـ «أصل» الـ «فاكتور 8» ماشي له
+
+931
+01:33:12,000 --> 01:33:23,880
+23 eggs on وبينهم 22 introns يعني لما أنا قاعد
+
+932
+01:33:23,880 --> 01:33:28,900
+أصنع البروتين هذا بسوي بالأول transcription
+
+933
+01:33:31,800 --> 01:33:38,700
+لدياء الـ RNA لكل الـ Introns والـ Exons وبعدين
+
+934
+01:33:38,700 --> 01:33:43,140
+بصير أقطع القطع واركبهم على بعض يعطيني البروتين
+
+935
+01:33:43,140 --> 01:33:47,220
+اللي أنا بديه واضح؟
+
+936
+01:33:47,220 --> 01:33:52,580
+في الحالة هذه، في بعض حالات الهيموفيليا اللي بيصير
+
+937
+01:33:52,580 --> 01:33:59,920
+أن هذولا القطعتين لا جات على بعض إذ ان احتمالي أنه
+
+938
+01:33:59,920 --> 01:34:08,420
+هيكيعني يشبك فلما يشبك وتيجي بعدين أنت تقول بدا
+
+939
+01:34:08,420 --> 01:34:14,140
+أفكه مرة ثانية بيصير الـ Loop بركب الطريقة معكوسة
+
+940
+01:34:14,140 --> 01:34:22,740
+فاهم عليك كيف الصورة حاطينها فاللي بيصير أن الـ AB
+
+941
+01:34:22,740 --> 01:34:28,400
+هذه القطعة اللي سببت الإشكالية راح تخليها تبدأ بدل
+
+942
+01:34:28,400 --> 01:34:34,540
+ما هو رقم 1تنين، تلاتي، لحد تلاتة وعشرين مظبوط
+
+943
+01:34:34,540 --> 01:34:38,540
+بهذا الشكل راح يصير اندي بيبدأ تنين وعشرين وواحد
+
+944
+01:34:38,540 --> 01:34:42,760
+وعشرين وكذا كذا لواحد وبعدين بيجي تلاتة وعشرين هنا
+
+945
+01:34:42,760 --> 01:34:48,800
+فراح يخربطلك الدنيا ويصير البروتين مالوش وظيفة ومش
+
+946
+01:34:48,800 --> 01:34:55,300
+كويس فاهم عليكي؟ فبعض حالات الـ Hemophilia
+
+947
+01:34:55,300 --> 01:35:05,150
+mutation بتكون بهذا الشكلوالسبب أنه يعني لما تدرس
+
+948
+01:35:05,150 --> 01:35:13,810
+بين الطبيعي وبين المصاب أول شيء كحجم DNA كامل
+
+949
+01:35:13,810 --> 01:35:19,590
+بتلاقي قطب بعض مافيش هلقلاق بس ترتيب القطع تبعات
+
+950
+01:35:19,590 --> 01:35:26,610
+الـ Egg Zone اللي هم بدخلوا فيه الـ Protein واللي
+
+951
+01:35:26,610 --> 01:35:31,600
+بينهم الـ Intronsهنا صارت الدنيا ملغوصة، مخربطة،
+
+952
+01:35:31,600 --> 01:35:36,520
+لا يمكن الاستفادة من هذا الاشياء وهذه بعض حالات
+
+953
+01:35:36,520 --> 01:35:48,120
+الـ Hemophilia وبتكون بهذا الشكل واضح؟ واضح كريم؟
+
+954
+01:35:48,120 --> 01:35:55,360
+تمام يا دكتور فهم علي، يعني هذه مثال أحيانًا يعني
+
+955
+01:35:55,360 --> 01:36:00,070
+اللي بدك تعرفها أنهالاختلالات الوراتية مش كلها على
+
+956
+01:36:00,070 --> 01:36:05,750
+طبيعة واحدة فقط يعني إن الـ «بروتين» أو الـ «جين»
+
+957
+01:36:05,750 --> 01:36:12,210
+مشيول تماماً، يعني غير موجود هذا «deletion» أي
+
+958
+01:36:12,210 --> 01:36:18,910
+طبيعة، بس هنا صار اللي هي قضية «reverse» الترتيب
+
+959
+01:36:18,910 --> 01:36:24,430
+القطع، في نفس الـ«جين» أحنا هنا مش جينات مختلفة،
+
+960
+01:36:24,430 --> 01:36:32,740
+فهذه أكزومللـ Hemophilia وهو مثال على الـ Genetic
+
+961
+01:36:32,740 --> 01:36:37,980
+Mutation بتخرّب الجين، بتخلّي الإنسان عنده نعور أو
+
+962
+01:36:37,980 --> 01:36:43,060
+Hemophilia وبيبطل يقدر يصنع البروتين هذا والسبب
+
+963
+01:36:43,060 --> 01:36:49,560
+أنه اختلف طريقة بطل صناعة البروتين بعدين كـ
+
+964
+01:36:49,560 --> 01:36:56,100
+Transcription و Translation بطلت تقدر تصنعه تمام؟
+
+965
+01:36:58,550 --> 01:37:01,650
+تمام، إن شاء الله هو يعني واضحة الصورة أعتقد عنده
+
+966
+01:37:01,650 --> 01:37:04,890
+في بس سؤال من بسمة بتسأل يعني الـBalance
+
+967
+01:37:04,890 --> 01:37:08,850
+Translocation يعني قصدك الـ… قصد على نفس الـslide
+
+968
+01:37:08,850 --> 01:37:15,130
+شكله؟ هاي، هنا بدك تعتبرها الـ… هنا مش
+
+969
+01:37:15,130 --> 01:37:18,570
+الـTranslocation، يعني الـTranslocation عمّا نحكي
+
+970
+01:37:18,570 --> 01:37:24,850
+عن Band، هنا إحنا بمستوى على one gene، يعني إحنا
+
+971
+01:37:24,850 --> 01:37:32,840
+هنا في مستوى أدقلما نحكي عن Band وقطع من الـ
+
+972
+01:37:32,840 --> 01:37:41,500
+Chromosomes وقطع أكبر، ماشي، إذا زي ما حطينا ال ..
+
+973
+01:37:41,500 --> 01:37:49,620
+إذا خليني أترجحكم صورة حطينا عن Down Syndrome Down
+
+974
+01:37:49,620 --> 01:37:56,220
+Syndrome Trisomy 21، واضح، عادة من هناكبس فيه نسبة
+
+975
+01:37:56,220 --> 01:38:04,520
+لما قاعد أدرس الـ الـ الـ الـ 21 Trisomy بلاقي
+
+976
+01:38:04,520 --> 01:38:10,900
+مافيش 21 Excess يعني فيه Two copies وبس فبكون إنه
+
+977
+01:38:10,900 --> 01:38:18,780
+فيه نسخة ثالثة راكبة على Chromosome 14 فهسة إذا
+
+978
+01:38:18,780 --> 01:38:24,770
+إنسان عندهنسخة واحدة فارضة فاضية من الـ Chromosome
+
+979
+01:38:24,770 --> 01:38:29,870
+21 والثاني الراكب على Chromosome 14 فبالأخير أنه
+
+980
+01:38:29,870 --> 01:38:33,230
+صار Two copies of Chromosome 21 وTwo copies of
+
+981
+01:38:33,230 --> 01:38:39,230
+Chromosome 14 وهذا Balance هذا هو نفسه إنسان طبيعي
+
+982
+01:38:39,230 --> 01:38:44,350
+لما يكون إنسان يكون Balance يعني كمية الـ DNA اللي
+
+983
+01:38:44,350 --> 01:38:50,010
+في جسمه الطبيعية مشابهة لكمية المتوقعة الطبيعية
+
+984
+01:38:50,380 --> 01:38:56,580
+وبالأخير مظهريًا لا يبدو عليه مرض ولكن تبتيب الـ
+
+985
+01:38:56,580 --> 01:39:03,220
+DNA لما بدي ييجي هو يخلف يصير تنقسم خلاياه وتعطي
+
+986
+01:39:03,220 --> 01:39:09,120
+الـ sperm والـ egg والـ ova وكذا بتلاقي إنه مستحيل
+
+987
+01:39:09,120 --> 01:39:15,380
+المربطين هذول أثنين مع بعض ينتصروا بشكل مناسب فإلا
+
+988
+01:39:15,380 --> 01:39:20,810
+الـ offspring cellsإلا يطلع ويا أما زيادة يا أما
+
+989
+01:39:20,810 --> 01:39:25,750
+نقصار واضح؟ فلما يكون الـ imbalance بتصير الأمراض
+
+990
+01:39:25,750 --> 01:39:34,410
+أكتر، بتكون فيه مشاكل أكتر، هذا المطلوب تمام
+
+991
+01:39:34,410 --> 01:39:38,710
+إن شاء الله إذا إن شاء الله نلتقي يوم الأربعة،
+
+992
+01:39:38,710 --> 01:39:44,710
+بنكمل على الحالات الثانية والأمراض الثانية، الله
+
+993
+01:39:44,710 --> 01:39:49,020
+يعطيكم ما يعطيهالله عفوك يا دكتور، يعطيك ألف عفو
+
+994
+01:39:49,020 --> 01:39:51,040
+أهلا وسهلا، السلام عليكم
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/Sczornve5Hk.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/Sczornve5Hk.srt
new file mode 100644
index 0000000000000000000000000000000000000000..7e26139fd11312556691797d8303ccee2499653a
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/Sczornve5Hk.srt
@@ -0,0 +1,1378 @@
+1
+00:00:00,000 --> 00:00:02,980
+باسم الله الرحمن الرحيم، الحمد لله رب العالمين
+
+2
+00:00:02,980 --> 00:00:10,280
+ونسال الله سبحانه وتعالى أن يوفقكم جميعًا لمعرفة
+
+3
+00:00:10,280 --> 00:00:14,260
+هذا العلم، يعني بالنسبة للوراثة، بالذات في الفصل
+
+4
+00:00:14,260 --> 00:00:23,520
+هذا حقيقة الوراثة جانب مهم جدًا، وجانب اللي دخل في
+
+5
+00:00:23,520 --> 00:00:27,220
+جوانب
+
+6
+00:00:27,220 --> 00:00:33,430
+كثير، طبية سواء في الأمراض، في فهمها، في التسبب
+
+7
+00:00:33,430 --> 00:00:40,730
+فيها، إلى دخل في قضية الآن كيف نفهم الـMechanisms،
+
+8
+00:00:40,730 --> 00:00:48,610
+الـDiseases، كيف بتتم تشخيصها، كيف بتتم علاجها، إلى
+
+9
+00:00:48,610 --> 00:00:54,080
+دخل في أشياء كثيرة. أحب أني دائمًا أسمع، حتى لو بعض
+
+10
+00:00:54,080 --> 00:01:02,120
+الطلاب، يعني، إذا حبوا يستوقفوا، حبوا، يعني حبوا
+
+11
+00:01:02,120 --> 00:01:06,120
+يسألوا سؤال، أو إذا فيه شيء مش واضح، لأن الكلام
+
+12
+00:01:06,120 --> 00:01:10,760
+واضح، حابب أسمع، يعني بحب تكون فيه مشاركة، يعني حتى
+
+13
+00:01:10,760 --> 00:01:17,370
+لو كان فيه جانب مش واضح، نتكلم عنه. الكلام واضح
+
+14
+00:01:17,370 --> 00:01:24,130
+للجميع. الأستاذ الدكتور أحمد سامعيني، ما شاء
+
+15
+00:01:24,130 --> 00:01:30,930
+الله، 80 طالب وطالبة. في حد عنده ملاحظة؟ إن شاء الله
+
+16
+00:01:30,930 --> 00:01:35,990
+المرات القادمة الأمور التقنية بتكون  أكثر حلًا
+
+17
+00:01:35,990 --> 00:01:40,810
+وفعلًا أنا حريص على إنه نسجل المحاضرات، عشان بأي وقت
+
+18
+00:01:40,810 --> 00:01:49,230
+عندكم حدا بده يشاهدها بوقت آخر، بيصير. بس إذا يعني
+
+19
+00:01:50,850 --> 00:01:56,670
+الآن تفاصيل الـcourse، بالنسبة لشو طريقة التقييم
+
+20
+00:01:56,670 --> 00:02:00,890
+وكيف طريقة الامتحانات، إن شاء الله قريبًا بعطيكم
+
+21
+00:02:00,890 --> 00:02:05,650
+إياها. الأخت عايشة، الدكتورة عايشة، بدها شيء، كان واحد
+
+22
+00:02:05,650 --> 00:02:12,050
+بدّه يفتح الـtelephone أو الـmicrophone، طيب.
+
+23
+00:02:14,120 --> 00:02:19,940
+بالنسبة لمواضيع الوراثة، أنا رجعت للكتاب اللي هو
+
+24
+00:02:19,940 --> 00:02:24,320
+«Genetics in Medicine»، «Thompson and Thomson»
+
+25
+00:02:24,320 --> 00:02:30,540
+وحقيقةً مرجع ممتاز، يمكن العيب الأساسي اللي فيه أنه
+
+26
+00:02:30,540 --> 00:02:35,080
+يمكن المعلومات اللي فيه أكثر من اللي الإنسان
+
+27
+00:02:35,080 --> 00:02:41,570
+بيحتاجها أحيانًا، كطبيب عام أو كطالب طب. بالتالي، مش
+
+28
+00:02:41,570 --> 00:02:46,730
+غلط الواحد يتعرض للمعلومات، وإن كان يعني مش ضروري
+
+29
+00:02:46,730 --> 00:02:51,610
+للحفظ وللامتحانات، بقدر ما أنه أنا بهمني أن يكون
+
+30
+00:02:51,610 --> 00:03:00,170
+الواحد فاهم المفاهيم، تكون أكثر بالنسبة
+
+31
+00:03:00,170 --> 00:03:09,650
+لمواضيع الـ...بالنسبة لمواضيع تاريخ علم المناعة
+
+32
+00:03:09,650 --> 00:03:13,190
+الحديث اللي إحنا بنعرفه، يعني أنا بظن إنه في
+
+33
+00:03:13,190 --> 00:03:21,190
+التاريخ، دائمًا هناك، يعني معرفته تساعد الواحد لفهم
+
+34
+00:03:21,190 --> 00:03:25,750
+كيف الأمر تطور بهذا الشكل اللي إحنا موجودين فيه
+
+35
+00:03:25,750 --> 00:03:32,030
+الآن. وبالتالي، يعني من أوائل الناس اللي يمكن كلكم
+
+36
+00:03:32,030 --> 00:03:36,980
+سمعتوا عنه، قضية مندل، مندل بالنسبة للوراثة، يعني
+
+37
+00:03:36,980 --> 00:03:42,560
+يُعتبر هو أبو الوراثة. آسف، أبو الوراثة
+
+38
+00:03:42,560 --> 00:03:53,160
+فمندل في الـ1800، كان راهب نمساوي، وعمل تجارب، يعني
+
+39
+00:03:53,160 --> 00:03:59,800
+حط، أو يعني لاحظ من خلالها ملاحظات معينة، كانت مهمة
+
+40
+00:03:59,800 --> 00:04:07,230
+جدا لوضع أسس في قضية الوراثة. بدنا نتذكر إنه الآن
+
+41
+00:04:07,230 --> 00:04:12,070
+إحنا بنحكي عن تاريخ مختلف تمامًا عن ما إحنا نعرفه
+
+42
+00:04:12,070 --> 00:04:19,390
+الآن، يعني الـDNA  والبروتين والـenzymes، وكيف
+
+43
+00:04:19,390 --> 00:04:26,930
+الجسم بيتعامل ويتفاعل، هذه كانت وقتها مجهولة، فيعني
+
+44
+00:04:26,930 --> 00:04:32,570
+كانت تجاربه هي من الملاحظات الأولى لقضية الوراثة.
+
+45
+00:04:35,120 --> 00:04:40,600
+و أرتيبولد جارود كمان، يعني وصف في اللي هو الـ
+
+46
+00:04:40,600 --> 00:04:46,720
+«الكابتو ريوريا»،  «الكابتو نيوريا»، «الكابتون
+
+47
+00:04:46,720 --> 00:04:52,160
+نيوريا»، اللي هو error in Aerometabolism، كان من
+
+48
+00:04:52,160 --> 00:04:56,660
+أوائل الناس اللي وصفه في سنة الـ1902، يعني هذه
+
+49
+00:04:56,660 --> 00:05:03,120
+بدايات علم الوراثة، وكانت بشكل، يعني، نعتبرها الآن
+
+50
+00:05:03,120 --> 00:05:09,500
+مجهولة، يعني كانت ظواهر بتكلموا عنها. إذا في أي
+
+51
+00:05:09,500 --> 00:05:13,040
+أسئلة، أنا بتكلم مرة بالعربي ومرة بالإنجليزي للأسف
+
+52
+00:05:13,040 --> 00:05:15,860
+هيك الواحد بيحاول يقربها. إذا إن شاء الله الكلام
+
+53
+00:05:15,860 --> 00:05:21,400
+واضح، وإذا أي حد بيشوف أي ملاحظة لشيء مش واضح من أي
+
+54
+00:05:21,400 --> 00:05:24,720
+ناحية يحكي، وممكن نعيد إن شاء الله.
+
+55
+00:05:29,420 --> 00:05:36,080
+بالنسبة لتجارب
+
+56
+00:05:36,080 --> 00:05:40,720
+مندل، يعني هو كانت على الـ«بازيلا»، على الـ«بيز»
+
+57
+00:05:40,720 --> 00:05:46,640
+وكان يعني عمل تجارب اللي هي كانت أول مرة بتظهر
+
+58
+00:05:46,640 --> 00:05:51,320
+للبشر، قضية إنه فيه صفات سائدة وفيه صفات متنحية، فيه
+
+59
+00:05:51,320 --> 00:05:56,940
+dominant traits، فيه recessive traits. فمثلًا،
+
+60
+00:05:56,940 --> 00:06:00,900
+بالنسبة، وأجرى تجارب على مدى سنين طويلة في أنواع
+
+61
+00:06:00,900 --> 00:06:07,140
+كثيرة، وكان يلقح النباتات بطريقة خاصة، بحيث إنه كان
+
+62
+00:06:07,140 --> 00:06:13,980
+النبات، إذا وردته بنفسجية أو وردته بيضاء، فالصفة
+
+63
+00:06:13,980 --> 00:06:20,600
+السائدة هي اللون البنفسجي. إذا كانت طريقة النمو، يعني
+
+64
+00:06:20,600 --> 00:06:23,500
+محوري، والـ
+
+65
+00:06:25,140 --> 00:06:31,660
+الوردة بتيجي في طرف النبتة ولا على جنبها، فإنه اللي
+
+66
+00:06:31,660 --> 00:06:36,160
+على الجنب هو الصفة السائدة. إذا كانت لون الحبة
+
+67
+00:06:36,160 --> 00:06:42,140
+البازيلاء صفراء أو خضراء، إنه اللون الأصفر هو السائد.
+
+68
+00:06:42,140 --> 00:06:50,000
+إذا كانت مستديرة ولا مجعدة ومكسرة، فإنها تكون
+
+69
+00:06:50,000 --> 00:06:57,880
+مستديرة، فهي هذه الصفة السائدة. شكل الحبة، أو
+
+70
+00:06:57,880 --> 00:07:11,740
+القطف البازلاء، أنه يكون، يعني، منفوخ أو مضموم. فلما
+
+71
+00:07:11,740 --> 00:07:17,440
+يعمل مثل هذه التجارب، فانتبه إلى أنه فيه صفات سائدة
+
+72
+00:07:17,440 --> 00:07:23,160
+وفيه صفات متنحية، هل هي طويلة أو قصيرة؟ فمن خلال هذه
+
+73
+00:07:23,160 --> 00:07:29,420
+التجارب، كانت أول ملاحظة للإنسان، أنه فيه مواد أو صفات
+
+74
+00:07:29,420 --> 00:07:38,740
+وراثية، شيء سائد وشيء متنحٍّ، سبحان الله. بقول الحفظ
+
+75
+00:07:38,740 --> 00:07:45,240
+الجيد لمندل في تجاربه هذه، قضية أنه، يعني، وهذه
+
+76
+00:07:45,240 --> 00:07:50,540
+بمحض صدفة كما يقال، إنه كل الصفات اللي درسها
+
+77
+00:07:50,540 --> 00:07:55,990
+بالشكل المختلف بهذه الطريقة، كانت على كروموزومات
+
+78
+00:07:55,990 --> 00:08:02,150
+منفصلة، يعني لو حدث إنه كان الصفة على صفتين أو أكثر
+
+79
+00:08:02,150 --> 00:08:05,810
+على نفس الكروموزوم، كانت هذه الظاهرة ما رح تتم
+
+80
+00:08:05,810 --> 00:08:13,910
+بهذا الوضوح. فكانت تجارب مندل، يعني عبارة عن تجارب
+
+81
+00:08:13,910 --> 00:08:19,810
+زراعية في بيته، وذكر نتائجها في دراسة بعد عشرات
+
+82
+00:08:19,810 --> 00:08:25,930
+الآلاف من التجارب، أو عدد كبير من التجارب. كانت النتيجة
+
+83
+00:08:25,930 --> 00:08:32,130
+أنها أهملت، وفقدت، وما...يعني ما اهتمّوا لها العلماء
+
+84
+00:08:32,130 --> 00:08:36,310
+وما أخذوا فيها لحد تقريبًا بعد أربعين سنة أو
+
+85
+00:08:36,310 --> 00:08:41,010
+ثلاثين سنة من وفاته، واكتشفوها مرة ثانية، وأثبتت
+
+86
+00:08:41,010 --> 00:08:48,530
+وكانت من الأشياء اللي، يعني، كانت بدايات فهم علم
+
+87
+00:08:48,530 --> 00:08:55,240
+الوراثة. إذا حد بيحب يسأل، يسأل، يعني إذا في شيء مش
+
+88
+00:08:55,240 --> 00:09:00,260
+واضح، ممكن نتكلم، بحب أسمع، إن شاء الله الشرح
+
+89
+00:09:00,260 --> 00:09:12,000
+واضح. حد بيحب يتكلم؟ أه، صار فيه مئة مشارك، دكتور
+
+90
+00:09:12,000 --> 00:09:16,700
+أحمد، واضح، عشان بلاش ندخل، وبعدين، تمام، دكتور،
+
+91
+00:09:16,700 --> 00:09:25,470
+أعتقد، الله، يعني من بدايات الفهم
+
+92
+00:09:25,470 --> 00:09:30,110
+للوراثة، كانت في تجارب زي تجارب مندل، وهي قضية
+
+93
+00:09:30,110 --> 00:09:33,870
+السائد والمتنحي بالنسبة للمادة الوراثية، وإن هناك
+
+94
+00:09:33,870 --> 00:09:38,910
+صفات مختلفة، ودا علماء آخرون، المفهوم أنهم لعبوا
+
+95
+00:09:38,910 --> 00:09:45,980
+أدوارًا كبيرة. مثلًا لامارك، في قضية أن البيئة هي التي
+
+96
+00:09:45,980 --> 00:09:53,940
+تُغير، وملاحظته لطول رقبة الزرافة، إنه بتعطيها أفضلية
+
+97
+00:09:53,940 --> 00:10:00,840
+في الطبيعة أو الحياة، أن تكون رقبتها أطول. فكانت هذه
+
+98
+00:10:00,840 --> 00:10:05,780
+أفكار في القرن التاسع عشر، ألف وثمان مئة. وحقيقةً يعني
+
+99
+00:10:05,780 --> 00:10:09,420
+حتى في أواخر تلك الفترة، أنه بدأنا نستخدم
+
+100
+00:10:09,420 --> 00:10:13,040
+المايكروسكوبات، والـMicrobiology، ونفهم التركيب
+
+101
+00:10:13,040 --> 00:10:18,360
+الكيميائي للمركبات، بما فيها يعني قضايا الـ
+
+102
+00:10:18,360 --> 00:10:23,540
+Carbohydrate، والبروتينات، والدهون. وبداية القرن
+
+103
+00:10:23,540 --> 00:10:30,220
+العشرين، تم بداية اكتشاف الـDNA، الـDeoxynucleic
+
+104
+00:10:30,220 --> 00:10:35,980
+Acid، يعني اللي هي الأحماض النووية. والأحماض النووية
+
+105
+00:10:35,980 --> 00:10:44,100
+يعني اللي راح نأخذها بشكل تفصيلي أكثر، في العشرينات
+
+106
+00:10:44,100 --> 00:10:52,840
+والثلاثينات. الـThymine، يعني كأحد القواعد
+
+107
+00:10:52,840 --> 00:10:57,880
+النيتروجينية، الـNitrogen Bases للـDNA، كان
+
+108
+00:10:57,880 --> 00:11:02,750
+اكتشافه، والاسم هذا لأنهما استطاعوا يعزلوا كمية
+
+109
+00:11:02,750 --> 00:11:07,250
+كافية منه، إلا من الـThymus تبعت الـThorax. ففي
+
+110
+00:11:07,250 --> 00:11:13,810
+دراسات معينة، كانوا يعزلوا كمادة كيميائية، وكان هناك
+
+111
+00:11:13,810 --> 00:11:19,590
+بداية، يعني، إعجاب وفهم للتركيب الكيميائي للمواد
+
+112
+00:11:19,590 --> 00:11:24,830
+العضوية، بما فيها الـCarbohydrate، والبروتين، والـ
+
+113
+00:11:24,830 --> 00:11:33,450
+Lipids، والأحماض النووية، الـNucleic Acids. كان هناك
+
+114
+00:11:33,450 --> 00:11:38,990
+أحيانًا، اشتباه إنه الوراثة، أو نقل الصفات من الآباء
+
+115
+00:11:38,990 --> 00:11:45,450
+للأبناء، والأمهات للأبناء، إنه من خلال، نفترض
+
+116
+00:11:45,450 --> 00:11:54,260
+البروتين نفسه. ولكن، تجارب بعد ذلك، وفهم أكبر للكيميا
+
+117
+00:11:54,260 --> 00:11:59,600
+الحيوية، والكيمياء الحيوية، أصبح هناك فهم لقضية أن
+
+118
+00:11:59,600 --> 00:12:07,060
+الـDNA، والمادة الوراثية، هي التي تشكل المادة
+
+119
+00:12:07,060 --> 00:12:11,720
+الوراثية، وهي التي تسبب نقل الصفات الوراثية. كيف هذا
+
+120
+00:12:11,720 --> 00:12:17,550
+الأمر بيتم؟ كيف هذا الأمر، يعني، ربنا وضعه فينا، هذه
+
+121
+00:12:17,550 --> 00:12:22,110
+هي القضية اللي أخذنا وقت طويل حتى استطعنا نفهمها.
+
+122
+00:12:22,110 --> 00:12:26,870
+وكان جزء أساسي منها، كما الآن كلكم تعرفوا، في سنة
+
+123
+00:12:26,870 --> 00:12:34,750
+الـ1953، أو في الخمسينات، واتسون وكريك، أعطوا  إنجازات على
+
+124
+00:12:34,750 --> 00:12:40,590
+تركيب الـDNA، باستخدام الـX-Ray Crystallography
+
+125
+00:12:40,590 --> 00:12:44,910
+وتقنيات معينة. كلما يمتلك الإنسان، أو العالم، أو
+
+126
+00:12:44,910 --> 00:12:50,910
+الطبيب، أو العالم، أو البشر أدوات، يمكنهم بها دراسة
+
+127
+00:12:50,910 --> 00:12:58,210
+أشياء أخرى، ممكن الواحد يكتشف ملاحظات جديدة، يعني
+
+128
+00:12:58,210 --> 00:13:04,340
+بدنا ندرس الفضاء، بدنا نجيب مناظير تليسكوبات أقوى،
+
+129
+00:13:04,340 --> 00:13:08,140
+بدنا ندرس تركيب الأشياء الأصغر، في الأصغر، في الأصغر،
+
+130
+00:13:08,140 --> 00:13:12,020
+بدنا مايكروسكوبات أقوى. أول مايكروسكوب، مايكروسكوب
+
+131
+00:13:12,020 --> 00:13:15,640
+الضوئي، يعني الـLight Microscopy، بالكثير،
+
+132
+00:13:15,640 --> 00:13:20,230
+بيجيب لك ألف مرة. الآن فيه Electron Microscopy، ممكن
+
+133
+00:13:20,230 --> 00:13:24,850
+توصل لحد 500، إلى 100، إلى مليون، 500 ألف مرة، إلى
+
+134
+00:13:24,850 --> 00:13:30,650
+مليون. فكل ما بتشوف عندك أدوات أدق، تستطيع إنك تشوف
+
+135
+00:13:30,650 --> 00:13:38,610
+أشياء أعمق. الفهم للبروتين، والـDNA، والتركيب، كيفية
+
+136
+00:13:38,610 --> 00:13:48,480
+التحكم في الصفات الوراثية، خلّى العلماء يدخلوا
+
+137
+00:13:48,480 --> 00:13:53,400
+في برنامج كلّف بلايين الدولارات، والأموال الكبيرة،
+
+138
+00:13:53,400 --> 00:14:01,320
+اللي هي الـHuman Genome Project، سنة التسعينات، بدأت
+
+139
+00:14:01,320 --> 00:14:08,400
+قضية أنه، يعني، راح نأخذ بعدين تفاصيل، كيف يعني الـ
+
+140
+00:14:08,400 --> 00:14:12,460
+DNA يكون مسؤول عن المادة الوراثية، كيف الـDNA بيوصل
+
+141
+00:14:12,460 --> 00:14:16,260
+إنه يعطينا الـProtein، اللي هو المظهر الخارجي
+
+142
+00:14:16,260 --> 00:14:22,950
+للمادة الحية. فكان اقتراح أحدهم، إنه نبدأ نقرأ اللي
+
+143
+00:14:22,950 --> 00:14:29,070
+هي أحرف المادة الوراثية للإنسان. طبعًا بدأت التجارب
+
+144
+00:14:29,070 --> 00:14:34,590
+أسبق من ذلك، في إنه يقرأوا المادة الوراثية لحيوانات
+
+145
+00:14:34,590 --> 00:14:40,490
+أدق، أو أصغر، أو كذا. فكان أول DNA Sequence، يعني
+
+146
+00:14:40,490 --> 00:14:45,130
+Whole Genome Sequence، لكل المادة الوراثية، هي
+
+147
+00:14:45,130 --> 00:14:50,360
+لذبابة الفاكهة، الـDrosophila. هذا من فترة أقدم
+
+148
+00:14:50,360 --> 00:14:55,400
+بعشرات السنين، يعني. عشان كان عشرين سنة أول حيوان، ولكن
+
+149
+00:14:55,400 --> 00:14:59,780
+قرروا بعدين، إنه ليش ما نقرأ الـDNA تبع الإنسان
+
+150
+00:14:59,780 --> 00:15:09,120
+كله؟ فبدأت من سنة 1990، وهي قراءة التسعة بلايين حرف
+
+151
+00:15:09,120 --> 00:15:14,320
+من القواعد النيتروجينية في الـDNA. الـDNA، يعني
+
+152
+00:15:14,320 --> 00:15:18,520
+اللي هو راح نأخذ تركيبه بعد شوية بتفصيل أكثر، هو
+
+153
+00:15:18,520 --> 00:15:28,380
+الكتاب الأصلي، أو المرجع في تكوين الإنسان. وبالتالي،
+
+154
+00:15:28,380 --> 00:15:36,640
+أتمنى إنه صورة واضحة، اللي هي إنه، يعني، هنا تفاصيل
+
+155
+00:15:36,640 --> 00:15:40,540
+المراحل
+
+156
+00:15:40,540 --> 00:15:47,730
+اللي تمت. نتذكر هنا إنه أول أجهزة
+
+157
+00:15:47,730 --> 00:15:51,330
+في  العالم عملت قراءة الـSequence، واللي بيسموها الـ
+
+158
+00:15:51,330 --> 00:15:59,070
+Sequencers، كانت بطيئة، وأن في كل مرحلة، وبدأت بعد
+
+159
+00:15:59,070 --> 00:16:04,980
+تقدم التكنولوجي. يعني هذه الصورة بتوصل لحد عام 2003،
+
+160
+00:16:04,980 --> 00:16:11,020
+من 1990، وكيف بدؤوا فيه قراءة المادة الوراثية
+
+161
+00:16:11,020 --> 00:16:16,520
+لحيوانات مختلفة. الآن الأجهزة التي تعمل عملية
+
+162
+00:16:16,520 --> 00:16:24,280
+القراءة، الـNucleotides، هذه أسرع بملايين المرات
+
+163
+00:16:24,760 --> 00:16:30,880
+يعني كل فترة وفترة، القدرة على قراءة الـSequences
+
+164
+00:16:30,880 --> 00:16:36,280
+هذه تصبح أسرع بكثير، ورح نتكلم على هذه الجوانب.
+
+165
+00:16:36,280 --> 00:16:41,780
+فالآن إنك تعمل، طبعًا أول Human Genome Project، يعني
+
+166
+00:16:41,780 --> 00:16:48,060
+ذكرت إنه كلّف تقريبًا
+
+167
+00:16:48,060 --> 00:16:55,740
+مليارات، اشتغل فيه حوالي، مش أقل من ألف مختبر في
+
+168
+00:16:55,740 --> 00:17:01,040
+العالم، في جامعات مختلفة، تم فيها محاولة قراءة
+
+169
+00:17:01,040 --> 00:17:08,900
+الأحرف تبع الـDNA لشخص معين. وبالتالي، يعني
+
+223
+00:22:02,040 --> 00:22:06,580
+عليها بشكل أدق أنا بفضل يكون في First و Second
+
+224
+00:22:06,580 --> 00:22:12,380
+Midterm و Final فبدها تقسيم الدرجات وتقسيم الأشياء
+
+225
+00:22:12,380 --> 00:22:19,940
+بالنسبة لشو تدرسوه، بقول الإلم، يعني زي المحيط، زي
+
+226
+00:22:19,940 --> 00:22:25,150
+الكمية هائلة من العلم، وعلم الله لا ينفد، علم الله
+
+227
+00:22:25,150 --> 00:22:33,010
+يعني بتلاقوه أوسع من أي شيء الإنسان يعني ممكن
+
+228
+00:22:33,010 --> 00:22:37,690
+يعرفه، سيظل فيه مجهول، سيظل فيه أشياء تكتشف، سيظل
+
+229
+00:22:37,690 --> 00:22:42,210
+لكل واحد منكم دور إنه يستخدم عقله، يستخدم
+
+230
+00:22:42,210 --> 00:22:48,770
+إمكاناته، دائماً يستخدم الواحد المنهج العلمي في نظر
+
+231
+00:22:48,770 --> 00:22:54,650
+للأشياء والحياة والدنيا، فأنا ما بسألكم بشكل المطلق
+
+232
+00:22:54,650 --> 00:23:01,630
+المطلق، الأصل الواحد يركز في المحاضرات بس أنا كمان
+
+233
+00:23:01,630 --> 00:23:06,610
+من واجبي لما نكون في امتحان أني أفرق بينكم، أن أرى
+
+234
+00:23:06,610 --> 00:23:12,390
+مين أحسن ومين أسوأ، فلازم تتوقعوا أنه في أشياء يعني
+
+235
+00:23:12,390 --> 00:23:17,370
+إذا الموضوع ما حكيته في المحاضرة ولا موجود في
+
+236
+00:23:17,370 --> 00:23:21,800
+الكتاب، ما راح أجيب لكم إياه، أما إذا موجود في الكتاب
+
+237
+00:23:21,800 --> 00:23:27,320
+والمرجع، أو ذكرته في المحاضرة، أو ما كانش في الكتاب بأي
+
+238
+00:23:27,320 --> 00:23:33,840
+جهتين فهو سؤال عادل للطلاب، ولازم يكون متوقعينه يعني
+
+239
+00:23:33,840 --> 00:23:42,780
+نسبة قليلة من الأسئلة تكون صعبة، شو اسمه؟ يعني هسا
+
+240
+00:23:42,780 --> 00:23:47,840
+بتقعدوا تسألوا: بكفي ولا ما بكفي؟ بقول: بكفي ولا ما
+
+241
+00:23:47,840 --> 00:23:53,920
+بكفي، برجع للواحد منكم، بدك ٩٥، ١٠٠ بالمئة،
+
+242
+00:23:53,920 --> 00:23:57,780
+تكون الأول على الدفعة، بدك تبدأ الجهد أكبر، بدك
+
+243
+00:23:57,780 --> 00:24:05,700
+نجاح  وسعيراً، والواحد يمشي حاله، مافي اسمه، يعني
+
+244
+00:24:05,700 --> 00:24:09,660
+ممكن يدرس المحاضرات، وأصلاً الـ slides تبعتي من
+
+245
+00:24:09,660 --> 00:24:16,960
+مرجع من الكتاب، الواحد لما في الطب كله لما يشوف مرجع
+
+246
+00:24:16,960 --> 00:24:23,000
+يمكن الكلام الصغير، التفاصيل الدقيقة ما يبقى يلحقش
+
+247
+00:24:23,000 --> 00:24:27,260
+يقراه أو يفهمه أو كده، إنما دائماً الصور والـ
+
+248
+00:24:27,260 --> 00:24:32,160
+«بوكس» اللي بتكون فيها تعليقات هيك أو فيها نقاط
+
+249
+00:24:32,160 --> 00:24:35,280
+واحد، اثنين، ثلاثة، أربعة، هذه الأشياء اللي الواحد
+
+250
+00:24:35,280 --> 00:24:41,210
+يركز عليها بالذات لأغراض الامتحانات، الأسئلة عن كيف
+
+251
+00:24:41,210 --> 00:24:45,730
+أدرس وما أدرس هيخليها ليّ يعني أنا بقول
+
+252
+00:24:45,730 --> 00:24:50,430
+بالأخير الواحد برجع إليه، وبعدين كل ما الواحد أو
+
+253
+00:24:50,430 --> 00:24:56,050
+الطالب أو الدكتور بعرف أكثر، مستوعب أكثر، عنده
+
+254
+00:24:56,050 --> 00:25:01,810
+يعني فهم أدق، يكون هو إنسان أحسن، يكون مرغوب أكثر،
+
+255
+00:25:01,810 --> 00:25:05,310
+يكون في أي مكان في العالم يبدو أنه يكون أحسن،
+
+256
+00:25:05,310 --> 00:25:12,890
+المهم الواحد يفهم المفاهيم، الأسئلة، خلّينا نكمل،
+
+257
+00:25:12,890 --> 00:25:21,730
+الكتاب، شوفوا، الطب والعلم متداخل مع بعضه، ماشي،
+
+258
+00:25:21,730 --> 00:25:26,150
+فكل ما بتعرف أكثر، بتسهل عليك في أشياء أخرى،
+
+259
+00:25:26,150 --> 00:25:31,930
+والمهم أنك أنت تفهم المبادئ، يعني يفهم الواحد
+
+260
+00:25:31,930 --> 00:25:33,050
+الكلام اللي بيستخدمه
+
+261
+00:25:35,770 --> 00:25:42,630
+الآن في المقدمة في كتابكم النقطة الأساسية والأولى
+
+262
+00:25:42,630 --> 00:25:51,610
+أنه إحنا كـ Genetics اللي هي المادة الوراثية اللي
+
+263
+00:25:51,610 --> 00:25:57,670
+هي تصف كيف الصفات المميزة لأي إنسان أو كائن حي
+
+264
+00:25:57,670 --> 00:26:02,730
+تنتقل من الآباء للأبناء، الـ
+
+265
+00:26:03,670 --> 00:26:09,250
+النظرة إلى كمية
+
+266
+00:26:09,250 --> 00:26:14,950
+المادة الوراثية بأكملها تسمى Genomics أو الـ
+
+267
+00:26:14,950 --> 00:26:21,030
+«جينوم»، الـ «جينوم» يعني الـ «جين» هو المادة
+
+268
+00:26:21,030 --> 00:26:26,330
+الوراثية اللي بتكون قطعة من الـ DNA عادةً نسبياً
+
+269
+00:26:26,330 --> 00:26:34,050
+صغيرة،  تُنسخ  ثم تترجم لتُصبح بروتين، في قطعة الـ DNA
+
+270
+00:26:34,050 --> 00:26:37,910
+اللي بتتحول إلى Messenger RNA اللي راح تعطينا الـ
+
+271
+00:26:37,910 --> 00:26:42,430
+Protein اللي بالأخير بيكون في الجسم، هذه اللي هو
+
+272
+00:26:42,430 --> 00:26:49,930
+الـ Gene، وبالتالي، يعني هناك حوالي، يعني بيقولوا
+
+273
+00:26:49,930 --> 00:26:57,250
+ما بين ٢٠ إلى ٢٥ ألف Gene في الـ DNA تبع الإنسان،
+
+274
+00:26:57,250 --> 00:27:06,450
+بنتقل الأمر إلى الـ Proteins، النظرة إلى كل الـ DNA
+
+275
+00:27:06,450 --> 00:27:14,290
+بأكمله، هنا نصبح نتكلم عن الـ Genomics، فهذه ظواهر
+
+276
+00:27:14,290 --> 00:27:21,270
+بتكون مسؤولة عن أمراض، طبعاً هي بالأول بتنقل الصفة
+
+277
+00:27:21,270 --> 00:27:26,590
+الوراثية من الأب والأم إلى الأبناء، ولكن أيضاً بتكون
+
+278
+00:27:26,590 --> 00:27:32,770
+مسؤولة عن التسبب بالأمراض، ونستخدمها لتشخيص أمراض
+
+279
+00:27:32,770 --> 00:27:35,950
+وأحياناً كثيرة ممكن نستخدمها حتى في علاج الأمراض
+
+280
+00:27:35,950 --> 00:27:39,650
+هناك
+
+281
+00:27:39,650 --> 00:27:44,430
+استفادة من المادة الوراثية مثلًا في الطب الشرعي،
+
+282
+00:27:44,430 --> 00:27:50,250
+نستخدم جوانب المادة الوراثية في هذه الفحوصات لإثبات
+
+283
+00:27:50,250 --> 00:27:57,970
+مثلًا الأبوة، والـ «إن فلان أبو فلان»، أو وجود علاقات
+
+284
+00:27:57,970 --> 00:28:04,710
+مثلًا «لا سمح الله، جثة لقيت، وتم أخذ جزء من الـ DNA»
+
+285
+00:28:04,710 --> 00:28:11,010
+وإذا شكينا إنه ممكن، بطريقة فحص الـ Genome نقول إن
+
+286
+00:28:11,010 --> 00:28:15,750
+هذا أقرب للعائلة الفلانية من العائلة الفلانية، هناك
+
+287
+00:28:15,750 --> 00:28:19,830
+جوانب في الـ Cancer Management، السرطانات عبارة عن
+
+288
+00:28:19,830 --> 00:28:26,750
+خلل في الـ DNA، جزء أساسي من التسبب فيها سواء
+
+289
+00:28:26,750 --> 00:28:33,250
+لتشخيص السرطان أو لعلاج السرطان، مما يتحكم في عملية
+
+290
+00:28:33,250 --> 00:28:40,950
+نقل الأعضاء، قضية الوراثة والـ Genome
+
+291
+00:28:40,950 --> 00:28:46,390
+والـ DNA، وكذا، هذه قضية يجب أن يكون هناك يعني
+
+292
+00:28:46,390 --> 00:28:50,850
+انتباه لها، أنها تتدخل الآن في قضايا كثيرة، القضايا
+
+293
+00:28:50,850 --> 00:28:56,390
+الطب، في قضية التشخيص، يعني الآن مثلًا الـ COVID-19
+
+294
+00:28:56,390 --> 00:29:03,530
+هذا الوباء الأخير في العالم، التشخيص الأدق له هو في
+
+295
+00:29:03,530 --> 00:29:09,810
+البحث عن الـ RNA تبع الفيروس في الـ Sample أو في
+
+296
+00:29:09,810 --> 00:29:15,700
+العينة، فالفحص الـ PCR اللي كلمة كنت بسمع عنها، لأنه
+
+297
+00:29:15,700 --> 00:29:19,980
+فيه طريقة فحص على وجود الالتهاب من خلال إثبات وجود
+
+298
+00:29:19,980 --> 00:29:26,620
+أجسام مضادة ضده، فهي الـ PCR هذا عبارة عن تقنية من
+
+299
+00:29:26,620 --> 00:29:32,880
+الـ Genetics والـ Genomics، وبنستخدمها كثيراً فالـ
+
+300
+00:29:32,880 --> 00:29:39,330
+يعني المطلوب أن يكون الإنسان، الطبيب، يفهم معنى الـ
+
+301
+00:29:39,330 --> 00:29:43,350
+«جين» والـ «جينوم»، الـ «جين» قطعة واحدة بتعطينا
+
+302
+00:29:43,350 --> 00:29:48,310
+الـ DNA اللي بيعطينا الـ RNA اللي بيعطينا الـ
+
+303
+00:29:48,310 --> 00:29:53,750
+«بروتين» اللي بيعطينا المظهر الخارجي، كل الآلة هذه
+
+304
+00:29:53,750 --> 00:30:01,530
+كاملة بمجملها تسمى «جينوم»، ترتيبات الـ DNA هذه
+
+305
+00:30:01,530 --> 00:30:04,970
+قضية راح نأخذها بالتفصيل، وهي قضية مهمة
+
+306
+00:30:10,120 --> 00:30:18,440
+وكأنواع الأمراض الوراثية، ماشي، طبعاً الآن الرأي
+
+307
+00:30:18,440 --> 00:30:24,280
+الأصح أن كل الأمراض وكل الظواهر عبارة عن تداخل ما
+
+308
+00:30:24,280 --> 00:30:28,240
+بين الوراثة والبيئة، Genetic and Environmental
+
+309
+00:30:28,240 --> 00:30:35,020
+Pathogenesis، يعني إلا يكون هناك مشاركة بين الوراثة
+
+310
+00:30:35,020 --> 00:30:41,800
+وبين البيئة لإعطاء المظاهر المختلفة، هناك تفاوت بين
+
+311
+00:30:41,800 --> 00:30:49,920
+درجة تأثير البيئة وتأثير الوراثة، يعني نفترض مثلًا
+
+312
+00:30:49,920 --> 00:30:56,710
+إنسان لم يتعرض للإشعاع، وإنسان تعرض للإشعاع، مادة
+
+313
+00:30:56,710 --> 00:31:00,750
+كيميائية، إنسان تعرض لها بكمية قليلة أو كمية كثيرة
+
+314
+00:31:00,750 --> 00:31:06,830
+من فيروس أو بكتيريا أو جرثومة أو حاجة، اللي تعرض
+
+315
+00:31:06,830 --> 00:31:10,090
+إليها ممكن ينصاب، اللي ما تعرضش إليها ممكن ما ينصابش
+
+316
+00:31:10,090 --> 00:31:15,330
+هذا الجانب، بس حتى في مثلًا تعرض إنسان لجرثومة
+
+317
+00:31:15,330 --> 00:31:20,380
+معينة، هناك اختلافات وراثية بين البشر تجعل
+
+318
+00:31:20,380 --> 00:31:27,260
+الإنسان مقاوم، وفيه إنسان معرض للمرض الشديد، فدائماً
+
+319
+00:31:27,260 --> 00:31:32,460
+هناك تداخل بين الجوانب الوراثية والجوانب البيئية
+
+320
+00:31:32,460 --> 00:31:39,880
+أنواع الأمراض الوراثية أو التي تتدخل فيها الوراثة
+
+321
+00:31:39,880 --> 00:31:46,160
+نقسمها إلى ثلاث درجات بشكل كبير كمقدمة، هناك
+
+322
+00:31:46,160 --> 00:31:51,900
+الـ Chromosomal Diseases، يعني عبارة عن مرض ناتج عن
+
+323
+00:31:51,900 --> 00:32:02,580
+خلل في قطعة كاملة تسمى الـ Chromosome، ماشي، الجسم
+
+324
+00:32:02,580 --> 00:32:08,660
+الملون، الـ Chromosome يسمى الجسم الملون، هو قطعة
+
+325
+00:32:08,660 --> 00:32:14,180
+من الـ DNA، وراح نأخذ ترتيبها لاحقاً
+
+326
+00:32:17,260 --> 00:32:23,580
+بحيث أنه نوقف عليها، أمراض ناتجة، يعني من أشهر
+
+327
+00:32:23,580 --> 00:32:28,060
+واحد الـ Down Syndrome، «تيرنر»، «كلاينفلتر»، Super
+
+328
+00:32:28,060 --> 00:32:34,520
+Women Diseases، يعني فيه، أو جزء من الـ Chromosome،
+
+329
+00:32:34,520 --> 00:32:39,800
+بس هو بيكون عدد الجينات فيه كبير، التجارب من هنا هي
+
+330
+00:32:39,800 --> 00:32:44,680
+أمثلة على ما يسمى Single Gene Disorder، يعني عبارة
+
+331
+00:32:44,680 --> 00:32:50,700
+عن مرض في جين واحد فقط، فيسمى الـ Mendelian
+
+332
+00:32:50,700 --> 00:32:55,360
+Inheritance، أو بتكون له صفة سائدة ومتَنحية، عندما نتكلم
+
+333
+00:32:55,360 --> 00:33:02,220
+عن خلل أو مرض نتيجة تغير في جين واحد، من كل هذه
+
+334
+00:33:02,220 --> 00:33:06,720
+الأعداد الكبيرة من الجينات، ولكن الغالبية العظمى من كثير من
+
+335
+00:33:06,720 --> 00:33:12,860
+الأمراض عبارة عن أمراض يكون عدد كبير من الجينات
+
+336
+00:33:12,860 --> 00:33:17,620
+مشتركة فيها، مثلًا، الربو القصبي، الـ Bronchial
+
+337
+00:33:17,620 --> 00:33:23,580
+asthma، بكون حوالي ما لا يقل عن خمسين جين داخل في
+
+338
+00:33:23,580 --> 00:33:33,240
+قضية التسبب بهذا المرض، وتدخل فيها ظواهر أخرى، راح
+
+339
+00:33:33,240 --> 00:33:37,100
+نتكلم فيها، علم التخلق اللي هي الـ Epigenetics اللي
+
+340
+00:33:37,100 --> 00:33:42,340
+هي أنه يشارك عدد كبير من الجينات بطريقة متناغمة
+
+341
+00:33:42,340 --> 00:33:47,980
+للتسبب بمرض معين زي السكري والضغط والربو ومشاكل
+
+342
+00:33:47,980 --> 00:33:53,960
+القلب، وكثير من الأمراض تجد أن وراثتها ليست وراثة
+
+343
+00:33:53,960 --> 00:33:58,900
+مندلية تابعة لجين واحد، إنما يكون عدد كبير من
+
+344
+00:33:58,900 --> 00:34:06,540
+الجينات مشتركة فيها، من المراجع، يعني الآن الطب يتغير
+
+345
+00:34:06,540 --> 00:34:11,540
+ومصادر العلوم تتغير، وإذا الـ «نت» مفتوح، وهو مصدر
+
+346
+00:34:11,540 --> 00:34:19,780
+غني جداً بالمعلومات الطبية، الـ «نت» يعني عيبه أو
+
+347
+00:34:19,780 --> 00:34:25,440
+مشكلته أنه بدك ترجع لمصادر جيدة، أحياناً هناك الغث
+
+348
+00:34:25,440 --> 00:34:31,880
+والسمين، هناك المفيد وهناك الضار، هناك يعني هي أدوات
+
+349
+00:34:31,880 --> 00:34:38,260
+تسمح لأي إنسان أن يكتب ما يريد، أو أي عالم يزعم
+
+350
+00:34:38,260 --> 00:34:42,660
+يدّعي ما يريد، ولكن يجب أن يدقق الإنسان ويستخدم
+
+351
+00:34:42,660 --> 00:34:48,620
+المراجع الجيدة، فمن الـ من الـ
+
+352
+00:34:51,110 --> 00:34:56,350
+من الأشياء اللي الآن موجودة، هناك جهود
+
+353
+00:34:56,350 --> 00:35:01,630
+مثلًا، هذا بالنسبة لقضية الـ، بالنسبة لقضية
+
+354
+00:35:01,630 --> 00:35:05,450
+المراجع، ممكن يستفيد منها، طبعاً التكنولوجيا الآن
+
+355
+00:35:05,450 --> 00:35:10,410
+متقدمة جداً، ويعني إذا الإنسان يكون متصلاً على الـ
+
+356
+00:35:10,410 --> 00:35:15,190
+«نت» ويكون يصل لهذه المراجع يكون يستطيع أن يرجع
+
+357
+00:35:15,190 --> 00:35:22,720
+منه الكثير من المقالات والمراجع العلمية، نسميها الـ
+
+358
+00:35:22,720 --> 00:35:26,520
+PubMed اللي هو تبع الـ National Institutes of
+
+359
+00:35:26,520 --> 00:35:33,280
+Health، هناك خدمة مفتوحة لعامة البشر في أنه يدخل
+
+360
+00:35:33,280 --> 00:35:37,480
+على الموقع هذا ويقرأ عن الأمراض والمقالات العلمية
+
+361
+00:35:37,480 --> 00:35:42,560
+الداخلة فيه، بس إذا الواحد انتبه، في نفس هذا الموقع
+
+362
+00:35:43,040 --> 00:35:46,060
+هناك أُخر، اللي هو الـ Online Mendelian
+
+363
+00:35:46,060 --> 00:35:51,780
+Inheritance in Man Database، فهذه قاعدة بيانات عن
+
+364
+00:35:51,780 --> 00:35:58,040
+جميع الأمراض الوراثية المندلية، اللي هي المقصود
+
+365
+00:35:58,040 --> 00:36:06,360
+أنها بتكون تابعة لجين واحد فقط، فهذه يعني مهمة
+
+366
+00:36:06,360 --> 00:36:13,080
+وأحياناً يعني ممكن، يعني تكون مرجع لأي واحد منا إذا
+
+367
+00:36:13,080 --> 00:36:19,180
+أجته حالة يعني معقدة، أو حالة لم يعرف عنها، أو ممكن
+
+368
+00:36:19,180 --> 00:36:24,620
+يكون هو يكتشف أول حالة، وهناك حاولنا نتكلم على
+
+369
+00:36:24,620 --> 00:36:31,180
+أمراض شائعة في منطقتنا، لأن كل منطقة في العالم لها
+
+370
+00:36:31,180 --> 00:36:39,060
+خصائص أو أمراض تكون أكثر شيوعاً، وذلك بسبب
+
+371
+00:36:39,060 --> 00:36:43,960
+طريقة الزواج، زواج الأقارب، قضية التعرض في البيئة
+
+372
+00:36:43,960 --> 00:36:50,540
+لأشياء معينة، فالتكنولوجيا الآن مفيدة ومتقدمة
+
+373
+00:36:50,540 --> 00:36:53,700
+وسنتكلم
+
+374
+00:36:53,700 --> 00:36:59,900
+على الـ Genomics، هناك دراسات تنظر إلى كل الجينات
+
+375
+00:36:59,900 --> 00:37:08,890
+بمجملها في الإنسان، وهناك مؤثرات فوق الوراثية
+
+376
+00:37:08,890 --> 00:37:13,310
+أو ما يسمى علم التخلق اللي هو إنه يؤثر على عدد
+
+377
+00:37:13,310 --> 00:37:20,010
+كبير من الجينات بطريقة يعني كما يقال مثل فرقة
+
+378
+00:37:20,010 --> 00:37:28,070
+أوركسترا موسيقية، بإشارة من قائدها، مجموعة عازفين سواء على
+
+379
+00:37:28,070 --> 00:37:32,980
+الطبل أو المزمار أو الكمان أو البيانو، بتلاقي
+
+380
+00:37:32,980 --> 00:37:37,000
+مجموعة كبيرة بتشتغل ومجموعة بتسكت، وبعد شوية بغير
+
+381
+00:37:37,000 --> 00:37:44,520
+كذا وبغير كذا، هذه الـ Epigenetics، هناك من التقدم
+
+382
+00:37:44,520 --> 00:37:51,580
+العلمي ما يدرس مثلاً تأثير مجمل الميكروبات التي
+
+383
+00:37:51,580 --> 00:37:55,740
+تعيش على الإنسان، في الجلد، في القناة الهضمية، على
+
+384
+00:37:55,740 --> 00:38:01,800
+الجهاز التنفسي، هذا يسمى الـ Microbiome، يعني هي أنت
+
+385
+00:38:01,800 --> 00:38:07,200
+لا تدرس فقط جرثومة واحدة أو وجودها أو عدم وجودها أو
+
+386
+00:38:07,200 --> 00:38:11,740
+دور جرثومة معينة، بقدر ما أنك أنت تدرس جميع
+
+387
+00:38:11,740 --> 00:38:17,560
+الميكروبات فيها
+
+388
+00:38:18,470 --> 00:38:27,590
+في الـ Exposomes والـ Proteomes، يعني الآن
+
+389
+00:38:27,590 --> 00:38:32,690
+حكينا في حوالي ٢٥ ألف جين في جسم الإنسان
+
+390
+00:38:32,690 --> 00:38:42,770
+في أمراض تكون نتيجة مثلًا تنشيط أو خمول أو تغيير
+
+391
+00:38:42,770 --> 00:38:48,650
+في عدد كبير من الجينات، فما هي الآلية التي يتم فيها
+
+392
+00:38:48,650 --> 00:38:55,450
+تغيير عدد كبير من الجينات بحيث أنه يعني كمثال
+
+393
+
+445
+00:44:30,740 --> 00:44:35,790
+راح نضلنا نتقابل وإن شاء الله موجودين، يعني اللي
+
+446
+00:44:35,790 --> 00:44:41,130
+بحبه أنه الآن خلصنا الفصل الأول في الكتاب، ودّيت
+
+447
+00:44:41,130 --> 00:44:46,250
+الـsoft copy التابعة له، تطلعوا عليها، اقرؤوها، إذا حدا
+
+448
+00:44:46,250 --> 00:44:50,790
+في أول جزء المحاضرة القادمة، راح نتكلم إن شاء الله
+
+449
+00:44:50,790 --> 00:44:55,570
+عنها، إذا في حد عنده أي أسئلة؟
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/Sczornve5Hk_postprocess.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/Sczornve5Hk_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..8668b8ec492e54ceda7e6c60773cdb0672a80804
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/Sczornve5Hk_postprocess.srt
@@ -0,0 +1,1796 @@
+1
+00:00:00,000 --> 00:00:02,980
+باسم الله الرحمن الرحيم، الحمد لله رب العالمين
+
+2
+00:00:02,980 --> 00:00:10,280
+ونفس الله سبحانه وتعالى أن يوفقكم جميعًا لمعرفة
+
+3
+00:00:10,280 --> 00:00:14,260
+هذا العلم يعني بالنسبة للوراثة، بالذات في الفصل
+
+4
+00:00:14,260 --> 00:00:23,520
+هذا حقيقة الوراثة جانب مهم كتير، وجانب اللي دخل في
+
+5
+00:00:23,520 --> 00:00:27,220
+جوانب
+
+6
+00:00:27,220 --> 00:00:33,430
+كتير، طبية سواءفي الأمراض، في الفهمها، في التسبب
+
+7
+00:00:33,430 --> 00:00:40,730
+فيها إلى دخل في قضية الآن كيف نفهم الـ Mechanisms،
+
+8
+00:00:40,730 --> 00:00:48,610
+الـ Diseases كيف بتتم تشخيصها، كيف بتتم علاجها إلى
+
+9
+00:00:48,610 --> 00:00:54,080
+دخل في أشياء كتيرةبحب أني دايما أسمع حتى لو بعض
+
+10
+00:00:54,080 --> 00:01:02,120
+الطلاب يعني إذا بحبوا يستوقفوا، بحبوا يعني بحبوا
+
+11
+00:01:02,120 --> 00:01:06,120
+يسألوا سؤال أو إذا فيه إشي مش واضح لأن الكلام
+
+12
+00:01:06,120 --> 00:01:10,760
+واضح، حابب أسمع، يعني بحب تكون فيه مشاركة يعني حتى
+
+13
+00:01:10,760 --> 00:01:17,370
+لو كان فيه جانب مش واضح، نتكلم عنهالكلام واضح
+
+14
+00:01:17,370 --> 00:01:24,130
+للجميع غير الأستاذ الدكتور أحمد سامعيني ما شاء
+
+15
+00:01:24,130 --> 00:01:30,930
+الله 80 طالب وطالبة في حد عنده ملاحظةإن شاء الله
+
+16
+00:01:30,930 --> 00:01:35,990
+المرات القادمة الأمور التقنية بتكون تنحل أكثر
+
+17
+00:01:35,990 --> 00:01:40,810
+وفعلا أنا حريص على إنه نسجل المحاضرات عشان بأي وقت
+
+18
+00:01:40,810 --> 00:01:49,230
+عندكم حدا بدي يشاهدها بوقت آخر بيصير بس إذا يعني
+
+19
+00:01:50,850 --> 00:01:56,670
+الأن تفاصيل ال course بالنسبة لشو طريقة التقييم
+
+20
+00:01:56,670 --> 00:02:00,890
+وكيف طريقة الامتحانات ان شاء الله قريبا بعطيكم
+
+21
+00:02:00,890 --> 00:02:05,650
+إياها الأخت عايشة الدكتورة عايشة بدها إشي كان واحد
+
+22
+00:02:05,650 --> 00:02:12,050
+بدى يفتح ال telephone أو ال microphone طيب
+
+23
+00:02:14,120 --> 00:02:19,940
+بالنسبة لمواضيع الوراثة أنا رجعت للكتاب اللي هو
+
+24
+00:02:19,940 --> 00:02:24,320
+«Genetics in Medicine» «Thompson and Thomson»
+
+25
+00:02:24,320 --> 00:02:30,540
+وحقيقةً مرجع ممتاز يمكن العيب الأساسي اللي فيه أنه
+
+26
+00:02:30,540 --> 00:02:35,080
+يمكن المعلومات اللي فيه أكثر من اللي الإنسان
+
+27
+00:02:35,080 --> 00:02:41,570
+بيحتاجها أحيانًا كطبيب عام أو كطالب طبوبالتالي مش
+
+28
+00:02:41,570 --> 00:02:46,730
+غلط الواحد يتعرض للمعلومات وإن كان يعني مش ضروري
+
+29
+00:02:46,730 --> 00:02:51,610
+للحفظ وللمتحانات بقدر ما أنه أنا بهمني أن يكون
+
+30
+00:02:51,610 --> 00:03:00,170
+الواحد فاهم المفاهيم تكون أكثر بالنسبة
+
+31
+00:03:00,170 --> 00:03:09,650
+لمواضيع ال .. بالنسبة لمواضيعتاريخية علم المناعة
+
+32
+00:03:09,650 --> 00:03:13,190
+الحديث اللي إحنا بنعرفه يعني أنا بظن إنه في
+
+33
+00:03:13,190 --> 00:03:21,190
+التاريخ دائماً هناك يعني معرفته تساعد الواحد لفهم
+
+34
+00:03:21,190 --> 00:03:25,750
+كيف الأمر اتطور بهذا الشكل اللي إحنا موجودين فيه
+
+35
+00:03:25,750 --> 00:03:32,030
+الآن وبالتالي يعني من أوائل الناس اللي يمكن كلكم
+
+36
+00:03:32,030 --> 00:03:36,980
+سمع عنه قضية «مندرن»مندل بالنسبة للمناعة يعني
+
+37
+00:03:36,980 --> 00:03:42,560
+يعتبر هو أبو المناعة أبو الحساسية آسف، أبو الوراثة
+
+38
+00:03:42,560 --> 00:03:53,160
+فالمندل بالـ 1800 كان راهب نمساوي وعمل تجارب يعني
+
+39
+00:03:53,160 --> 00:03:59,800
+حط أو يعني لاحظ من خلالها ملاحظات معينة كانت مهمة
+
+40
+00:03:59,800 --> 00:04:07,230
+كثير لوضع أسس في قضية الوراثةبدنا نتذكر إنه الآن
+
+41
+00:04:07,230 --> 00:04:12,070
+إحنا بنحكي عن تاريخ مختلف تماماً عن ما إحنا نعرفه
+
+42
+00:04:12,070 --> 00:04:19,390
+الآن يعني الـ DNA والبروتين والـ enzymes وكيف
+
+43
+00:04:19,390 --> 00:04:26,930
+الجسم بتعامل ويتفاعل هذه كانت وقتها مجهولة، فيعني
+
+44
+00:04:26,930 --> 00:04:32,570
+كانت تجاربه هي من الملاحظات الأولى لقضية الوراثة
+
+45
+00:04:35,120 --> 00:04:40,600
+و«أرتيبولد جارود» كمان يعني وصف في اللي هو الـ
+
+46
+00:04:40,600 --> 00:04:46,720
+«الكابتو بيورينيا» «الكابتو نيوريا» «الكابتون
+
+47
+00:04:46,720 --> 00:04:52,160
+نيوريا» اللي هو Emperor in Aerometabolism كان من
+
+48
+00:04:52,160 --> 00:04:56,660
+أوائل الناس اللي وصفه في سنة الـ1902 يعني هذه
+
+49
+00:04:56,660 --> 00:05:03,120
+بدايات العلم الوراثة وكانت بشكل يعنينعتبرها الآن
+
+50
+00:05:03,120 --> 00:05:09,500
+مجهولة يعني كانت طواهر بتكلموا عنها إذا في أي
+
+51
+00:05:09,500 --> 00:05:13,040
+أسئلة أنا بتكلم مرة بالعربي و مرة بالإنجليزي للأسف
+
+52
+00:05:13,040 --> 00:05:15,860
+هيك الواحد طالع ينقربها إذا إن شاء الله الكلام
+
+53
+00:05:15,860 --> 00:05:21,400
+واضح وإذا أي حد بيشوف أي ملاحظة لشيء مش واضح من أي
+
+54
+00:05:21,400 --> 00:05:24,720
+ناحية يحكي وممكن نعيد إن شاء الله
+
+55
+00:05:29,420 --> 00:05:36,080
+بالنسبة لـ «تجارب
+
+56
+00:05:36,080 --> 00:05:40,720
+مندل» يعني هو كانت على الـ «بازيلا» على الـ «بيز»
+
+57
+00:05:40,720 --> 00:05:46,640
+وكان يعني عملت تجارب اللي هي كانت أول مرة بتظهر
+
+58
+00:05:46,640 --> 00:05:51,320
+للبشر قضية إنه فيه صفات سائدة وفيه صفات متنحية فيه
+
+59
+00:05:51,320 --> 00:05:56,940
+dominant traits، فيه recessive traitsفمثلًا،
+
+60
+00:05:56,940 --> 00:06:00,900
+بالنسبة وأجرى تجارب على مدى سنين طويلة في أنواع
+
+61
+00:06:00,900 --> 00:06:07,140
+كثيرة وكان يلقح النباتات بطريقة خاصة بحيث إنه كان
+
+62
+00:06:07,140 --> 00:06:13,980
+النبات إذا وردته بنفسجية أو وردته بيضة فالصفة
+
+63
+00:06:13,980 --> 00:06:20,600
+الساعدة هي اللون البنفسجي إذا كان طريقة النمو يعني
+
+64
+00:06:20,600 --> 00:06:23,500
+محوري والـ
+
+65
+00:06:25,140 --> 00:06:31,660
+الوردة بتيجي في طرف النبتة ولا على جنبها فإنه اللي
+
+66
+00:06:31,660 --> 00:06:36,160
+على الجنب هو الصفة السائدة إذا كانت كلون الحبّة
+
+67
+00:06:36,160 --> 00:06:42,140
+البازيلة صفراء أو خضراء إنه اللون الأصفر هو السائد
+
+68
+00:06:42,140 --> 00:06:50,000
+إذا كانت مستديرة ولا مجعلة ومكسرة فإنها تكون
+
+69
+00:06:50,000 --> 00:06:57,880
+مستديرة وواضحة فهي هذا الصفة السائدةالشكل الحبة أو
+
+70
+00:06:57,880 --> 00:07:11,740
+القطف البازلاء أنه يكون يعني منفوخ أو مضموم فلمّا
+
+71
+00:07:11,740 --> 00:07:17,440
+يعمل مثل هذه التجارب فانتبه إلى أنه فيه صفات سائدة
+
+72
+00:07:17,440 --> 00:07:23,160
+وفيه صفات متنحية هل هي طويلة أو قصيرة فمن خلال هذه
+
+73
+00:07:23,160 --> 00:07:29,420
+التجاربكانت أول ملاحظة لبنسان أنه فيه مواد أو صفات
+
+74
+00:07:29,420 --> 00:07:38,740
+وراثية إشي ساعد وإشي متنحن سبحان الله، بقول الحفظ
+
+75
+00:07:38,740 --> 00:07:45,240
+الجيد لمندل في تجاربه هذه قضية أنه، يعني وهذه
+
+76
+00:07:45,240 --> 00:07:50,540
+بمحدث صدفة كما يقال إنه كل الصفات اللي درسها
+
+77
+00:07:50,540 --> 00:07:55,990
+بالشكل المختلف بهذه الطريقةكانت على كروموزومات
+
+78
+00:07:55,990 --> 00:08:02,150
+منفصلة يعني لو حدث إنه كان الصفة على صفتين أو أكثر
+
+79
+00:08:02,150 --> 00:08:05,810
+على نفس الكروموزوم كانت هذه الظاهرة ما راح تتم
+
+80
+00:08:05,810 --> 00:08:13,910
+بهذا الوضوح فكانت تجارب مندل يعني عبارة عن تجارب
+
+81
+00:08:13,910 --> 00:08:19,810
+زراعية في بيته وذكر نتائجها في دراسة بعد عشرات
+
+82
+00:08:19,810 --> 00:08:25,930
+آلاف التجارب أو عدد كبير من التجاربكانت النتيجة
+
+83
+00:08:25,930 --> 00:08:32,130
+أنها أهملت وفقدت وما .. يعني ما اهتمولها العلماء
+
+84
+00:08:32,130 --> 00:08:36,310
+وما أخذوا فيها لحد تقريبًا بعد أربعين سنة أو
+
+85
+00:08:36,310 --> 00:08:41,010
+ثلاثين سنة من وفاته واكتشفوها مرة ثانية وأثبتت
+
+86
+00:08:41,010 --> 00:08:48,530
+وكانت من الأشياء اللي يعني كانت بدايات فهم علم
+
+87
+00:08:48,530 --> 00:08:55,240
+الوراثةإذا حد بيحب يسأل، يسأل، يعني إذا في شيء مش
+
+88
+00:08:55,240 --> 00:09:00,260
+واضح، ممكن نتكلم، بحب أسمع، إن شاء الله الشرح
+
+89
+00:09:00,260 --> 00:09:12,000
+واضح، حد بيحب يتكلم، أهي صار فيه مئة مشارك، دكتور
+
+90
+00:09:12,000 --> 00:09:16,700
+أحمد واضح، عشان بلاش ندخل و بعدين، تمام، دكتور،
+
+91
+00:09:16,700 --> 00:09:25,470
+اتوقع اللهالـ يعني من بدايات الفهمنة
+
+92
+00:09:25,470 --> 00:09:30,110
+للوراثة كانت في تجارب زي التجارب من دلوقت وهي قضية
+
+93
+00:09:30,110 --> 00:09:33,870
+الساعد والمتنحي بالنسبة للمادة الوراثية وإن هناك
+
+94
+00:09:33,870 --> 00:09:38,910
+صفات مختلفة ودا أشخاص أخرون المفهوم أنهم يلهم
+
+95
+00:09:38,910 --> 00:09:45,980
+أدوار كبيرة مثلا Lamarckفي قضية أن البيئة هي التي
+
+96
+00:09:45,980 --> 00:09:53,940
+تغير وملاحظته لطول رقبة الزرافة إنه تعطيها أفضلية
+
+97
+00:09:53,940 --> 00:10:00,840
+في الطبيعة أو الحياة أن تكون رقبتها أطول فكانت هذه
+
+98
+00:10:00,840 --> 00:10:05,780
+أفكار بالقرن التاسع عشر، الف وثمانميةوحقيقةً يعني
+
+99
+00:10:05,780 --> 00:10:09,420
+حتى في أواخر تلك الأهد أنه بدأنا نستخدم
+
+100
+00:10:09,420 --> 00:10:13,040
+المايكروسكوبات والـ Microbiology ونفهم التركيب
+
+101
+00:10:13,040 --> 00:10:18,360
+الكيموي للمراكبات بما فيها يعني قضايا الـ
+
+102
+00:10:18,360 --> 00:10:23,540
+Carbohydrate والبروتينات والدهون وبداية القرن
+
+103
+00:10:23,540 --> 00:10:30,220
+الأشرين تم بداية اكتشاف الـ DNA الـ Deoxynucleic
+
+104
+00:10:30,220 --> 00:10:35,980
+Acid يعني اللي هي الأحماض النوويةوالأحماض النووية
+
+105
+00:10:35,980 --> 00:10:44,100
+يعني اللي راح نخدها بشكل تفصيلي أكثر في الأشرينات
+
+106
+00:10:44,100 --> 00:10:52,840
+والثلاثينات الـ Thymine يعني كأحد القواعد
+
+107
+00:10:52,840 --> 00:10:57,880
+النيتروجينية الـ Nitrogen Bases للـ DNA كان
+
+108
+00:10:57,880 --> 00:11:02,750
+اكتشافه والاسم هذا لأنهما استطاعوا يعزلوا كمية
+
+109
+00:11:02,750 --> 00:11:07,250
+كافية منه إلا من الـ Thymus تبعت الـ Thor ففي
+
+110
+00:11:07,250 --> 00:11:13,810
+دراسات معينة كانوا يعزلوا كمادة كيموية وكان هناك
+
+111
+00:11:13,810 --> 00:11:19,590
+بداية يعني إعجاب وفهم للتركيب الكيموي للمواد
+
+112
+00:11:19,590 --> 00:11:24,830
+العضويةفبما فيها الـ Carbohydrate والبروتين والـ
+
+113
+00:11:24,830 --> 00:11:33,450
+Lipids والأحماض النووية الـ Nucleic Acids كان هناك
+
+114
+00:11:33,450 --> 00:11:38,990
+أحيانًا اشتباه إنه وراثة أو نقل الصفات من الأباء
+
+115
+00:11:38,990 --> 00:11:45,450
+للأبناء والأمهات للأبناء إنه من خلال نفترض
+
+116
+00:11:45,450 --> 00:11:54,260
+البروتين نفسه ولكن تجارببعد ذلك، وفهم أكبر للكيميا
+
+117
+00:11:54,260 --> 00:11:59,600
+الأضوية والكيميا الحيوية أصبح هناك فهم لقضية أن
+
+118
+00:11:59,600 --> 00:12:07,060
+الـ «DNA» والمادة الوراثية هي التي تشكل المادة
+
+119
+00:12:07,060 --> 00:12:11,720
+الوراثية وهي التي تسبب نقل الصفات الوراثية كيف هذا
+
+120
+00:12:11,720 --> 00:12:17,550
+الأمر بتتم؟كيف هذا الأمر يعني ربنا وضعه فينا هذه
+
+121
+00:12:17,550 --> 00:12:22,110
+هي القضية اللي أخذنا وقت طويل حتى استطعنا نفهمها
+
+122
+00:12:22,110 --> 00:12:26,870
+وكان جزء أساسي منها كما الآن كلكم تعرفوا في سنة
+
+123
+00:12:26,870 --> 00:12:34,750
+الـ54 أو بالخمسينات واتسون والكريك أعطوامبادع على
+
+124
+00:12:34,750 --> 00:12:40,590
+تركيب الـ DNA باستخدام الـ X-Ray وCrystalography
+
+125
+00:12:40,590 --> 00:12:44,910
+وتقنيات معينة كلما يمتلك الإنسان أو العالم أو
+
+126
+00:12:44,910 --> 00:12:50,910
+الطبيب أو العالم أو البشر أدوات يمكنهم بها دراسة
+
+127
+00:12:50,910 --> 00:12:58,210
+أشياء أخرى ممكن الواحد يكتشف ملاحظات جديدة يعني
+
+128
+00:12:58,210 --> 00:13:04,340
+بدنا ندرس الفضاء، بدنا نجيبمناظير تليسكوب أقوى،
+
+129
+00:13:04,340 --> 00:13:08,140
+بدنا ندرس تركيب الأشياء الأصغر في أصغر في أصغر،
+
+130
+00:13:08,140 --> 00:13:12,020
+بدنا مايكروسكوبات أقوى، أول مايكروسكوب، مايكروسكوب
+
+131
+00:13:12,020 --> 00:13:15,640
+الضوئي، يعني الـ Light Microscopy، بالكثير،
+
+132
+00:13:15,640 --> 00:13:20,230
+بيجيبلك ألف مرةالآن فيه Electron Microscopy ممكن
+
+133
+00:13:20,230 --> 00:13:24,850
+توصل لحد 500 إلى 100 إلى مليون 500 ألف مرة إلى
+
+134
+00:13:24,850 --> 00:13:30,650
+مليون فكل ما بتشوف عندك أدوات أدق تستطيع إنك تشوف
+
+135
+00:13:30,650 --> 00:13:38,610
+أشياء أعمق الفهم للبروتين والـDNA والتركيب كيفية
+
+136
+00:13:38,610 --> 00:13:48,480
+التحكم في الصفات الوراثيةخلّت العلماء يدخلوا
+
+137
+00:13:48,480 --> 00:13:53,400
+في برنامج كلف بلايين الدولارات والأموال الكبيرة
+
+138
+00:13:53,400 --> 00:14:01,320
+اللي هي الـ Human Genome Project سنة التسعينبدأت
+
+139
+00:14:01,320 --> 00:14:08,400
+قضية أنه يعني راح ناخد بعدين تفاصيل كيف يعني الـ
+
+140
+00:14:08,400 --> 00:14:12,460
+DNA يكون مسؤول عن المادة الوراثية كيف الـ DNA بوصل
+
+141
+00:14:12,460 --> 00:14:16,260
+أنه يعطينا الـ Protein اللي هو المظهر الخارجي
+
+142
+00:14:16,260 --> 00:14:22,950
+للمادة الحية فكان اقتراح أحدهمإنه نبدأ نقرأ اللي
+
+143
+00:14:22,950 --> 00:14:29,070
+هي أحرف المادة الوراثية لإنسان طبعاً بدت التجارب
+
+144
+00:14:29,070 --> 00:14:34,590
+أسبق من ذلك في إنه يقرأوا المادة الوراثية لحيوانات
+
+145
+00:14:34,590 --> 00:14:40,490
+أدق أو أصغر أو كده فكان أول DNA Sequence يعني
+
+146
+00:14:40,490 --> 00:14:45,130
+Whole Genome Sequence لكل المادة الوراثية هي
+
+147
+00:14:45,130 --> 00:14:50,360
+لذبابة الفاكهة الـ Drosophilaهذا من فترة أقدم
+
+148
+00:14:50,360 --> 00:14:55,400
+عشرات سنين يعني عشان كان عشرين سنة أول حيوان ولكن
+
+149
+00:14:55,400 --> 00:14:59,780
+قرروا بعدين إنه ليش ما نقرأ الـ DNA تبع الإنسان
+
+150
+00:14:59,780 --> 00:15:09,120
+كله فبدت من سنة 1990 وهي قراءة التسعة بلايين حرف
+
+151
+00:15:09,120 --> 00:15:14,320
+من القواعد النيتروجينية في الـ DNAالـ DNA يعني
+
+152
+00:15:14,320 --> 00:15:18,520
+اللي هو راح ناخد تركيبه بعد شوية بتفصيل أكتر هو
+
+153
+00:15:18,520 --> 00:15:28,380
+الكتاب الأصلي أو المرجع في تكوّل الإنسان وبالتالي
+
+154
+00:15:28,380 --> 00:15:36,640
+أتأمل إنه صورة واضحة اللي هي إنه يعني هنا تفاصيل
+
+155
+00:15:36,640 --> 00:15:40,540
+المراحل
+
+156
+00:15:40,540 --> 00:15:47,730
+اللي تمتبذكر هنا إنه أول أجهزة
+
+157
+00:15:47,730 --> 00:15:51,330
+في فضية عمل قراءة الـ Sequence واللي بيسموها الـ
+
+158
+00:15:51,330 --> 00:15:59,070
+Sequencers كانت بطيئة وأن في كل مرحلة، وبدأت بعد
+
+159
+00:15:59,070 --> 00:16:04,980
+تقدم التكنولوجييعني هذه الصورة بتوصل لحد عام 2003
+
+160
+00:16:04,980 --> 00:16:11,020
+من 1990 وكيف بدوا فيه قراءة المادة الوراثية
+
+161
+00:16:11,020 --> 00:16:16,520
+لحيوانات مختلفة الآن الأجهزة التي تعمل عملية
+
+162
+00:16:16,520 --> 00:16:24,280
+القراءة الـ Nucleotides هذه أكفأ بملايين المرات
+
+163
+00:16:24,760 --> 00:16:30,880
+يعني كل فترة وفترة القدرة على قراءة الـ Sequences
+
+164
+00:16:30,880 --> 00:16:36,280
+هدولة تصبح أسرع بكثير ورح نتكلم على هذه الجوالب
+
+165
+00:16:36,280 --> 00:16:41,780
+فالآن إنك تعمل طبعاً أول Human Genome Project يعني
+
+166
+00:16:41,780 --> 00:16:48,060
+ذكرت إنه تكلف تقريباً
+
+167
+00:16:48,060 --> 00:16:55,740
+مليارات أشتغل فيه حوالي مش أقل من ألفمختبر في
+
+168
+00:16:55,740 --> 00:17:01,040
+العالم في جامعات مختلفة تم فيها محاولة قراءة
+
+169
+00:17:01,040 --> 00:17:08,900
+الأحرف تبع في الـ DNA لشخص معين وبالتالي يعني قعد
+
+170
+00:17:08,900 --> 00:17:13,940
+مش أقل من يمكن أقل شويه من عشر سنوات وهم يقرأوا
+
+171
+00:17:13,940 --> 00:17:21,420
+فيها الآن كل هذا الجهد في خلال يومين، ثلاثة في
+
+172
+00:17:21,420 --> 00:17:26,010
+أجهزة بتقرار بالكاملكان بالأول يعني هناك تقدم رهيب
+
+173
+00:17:26,010 --> 00:17:29,190
+في
+
+174
+00:17:29,190 --> 00:17:35,670
+أسئلة إن شاء الله الأمور واضحة يعني هذه مقدمة
+
+175
+00:17:35,670 --> 00:17:42,770
+نعتبرها تاريخية لألم الوراثة الحالي طبعاً بتدخل في
+
+176
+00:17:42,770 --> 00:17:48,930
+كثير من الجوانب ويله تطبيقات مهمة في جوانب كثيرة
+
+177
+00:17:48,930 --> 00:17:52,750
+في أسئلة إذا حد عنده سؤال
+
+178
+00:17:57,990 --> 00:18:07,490
+كيف حالكم؟ إن شاء الله كويسين، طيب، في
+
+179
+00:18:07,490 --> 00:18:08,170
+أسئلة؟
+
+180
+00:18:13,750 --> 00:18:17,950
+زي عاديتك يا دكتور يعني طبعًا يا شباب ويا أخواتنا
+
+181
+00:18:17,950 --> 00:18:22,010
+إذا حد بيحب يسأل يمكنه يعني يستخدم إشارة رفع اليد
+
+182
+00:18:22,010 --> 00:18:26,750
+أو يبعت تعليج يعني إشارة رفع اليد طبعًا دكتور ممكن
+
+183
+00:18:26,750 --> 00:18:30,850
+يعمله «unmute» ويسمع منه السؤال عاد مشارك أه أنا
+
+184
+00:18:30,850 --> 00:18:34,170
+حاليًا على الـ «Zoom» حاطة «full screen» يعني
+
+185
+00:18:34,170 --> 00:18:38,490
+مابيينش معاه إذا حد بيحب يتكلم الـ«chats» 32
+
+186
+00:18:42,470 --> 00:18:45,970
+طيب، هنا في واحد بيطلب أشرح عن حالي، إن شاء الله
+
+187
+00:18:45,970 --> 00:18:52,370
+بكلمكم، خلّيها بالأخيرة شوية طيب،
+
+188
+00:18:52,370 --> 00:18:58,910
+في حد بيحب يسأل عن المادة العلمية، يعني أنا الـ
+
+189
+00:18:58,910 --> 00:19:02,350
+أنا شخصياً
+
+190
+00:19:02,350 --> 00:19:07,470
+يعني أهلي في الأصل منظفة الغربية، من ارتاح طول كرم
+
+191
+00:19:07,470 --> 00:19:11,930
+كنا في الكويت، أخرج جامعة الكويتذهبت للولايات
+
+192
+00:19:11,930 --> 00:19:15,650
+المتحدة الأمريكية وطلصت باطنية ومناعة وحساسية
+
+193
+00:19:15,650 --> 00:19:20,010
+المناعة والحساسية الـ Genetics تبعتها من أصعب
+
+194
+00:19:20,010 --> 00:19:27,910
+المواد الوراثة يعني المفاهيم يعني الـ حتى الواحد
+
+195
+00:19:27,910 --> 00:19:33,710
+يفهم توقعاً المناعة والحساسية ولا الوراثة بدي يكون
+
+196
+00:19:33,710 --> 00:19:41,760
+فاهمة فاهم دقيق بما فيها الـ الـ الـ الـالمبادئ
+
+197
+00:19:41,760 --> 00:19:47,280
+العلمية إلها من تراكيب كيميا حيوية كيف تشتغل
+
+198
+00:19:47,280 --> 00:19:54,420
+ونهايتها كيف بتأثر على البني آدمفأنا International
+
+199
+00:19:54,420 --> 00:19:57,900
+Fellow للـ American Academy of Allergy, Asthma and
+
+200
+00:19:57,900 --> 00:20:04,320
+Immunology الـ Epigenetics والـ Genetics والـ الـ
+
+201
+00:20:04,320 --> 00:20:08,120
+Genetics للـ Immune System صراحة من أعقد المواضيع
+
+202
+00:20:08,120 --> 00:20:14,500
+والموضوع كله سهل بالنسبالي أنا بشتغل فيه كمان
+
+203
+00:20:14,500 --> 00:20:18,180
+مستشار في اللجنة الأردنية لدعم الـ أنا استغلت في
+
+204
+00:20:18,180 --> 00:20:21,550
+جامعة الـعلوم التكنولوجيا الأردنية في كلية الطب
+
+205
+00:20:21,550 --> 00:20:27,650
+وكلية التقنيات الطبية أستاذ مشارك وأنا مستشار في
+
+206
+00:20:27,650 --> 00:20:32,810
+لجنة الأردنية لدعم القطاع الصحي في غزة لجنة في
+
+207
+00:20:32,810 --> 00:20:39,410
+النقابات الصحية في الأردن متخصصين في دعم القطاع
+
+208
+00:20:39,410 --> 00:20:45,220
+الصحي في غزة نشرف على تدريب أطباء في الأردنيعني
+
+209
+00:20:45,220 --> 00:20:49,280
+إحنا كلنا شعب واحد و أم واحدة و أنا بشرفني و
+
+210
+00:20:49,280 --> 00:20:58,860
+بسعدني أني أكون أقدر أساعدكم الآن بالنسبة كيفية
+
+211
+00:20:58,860 --> 00:21:01,740
+الدراسات الدراسة من الـ slides و لا من الكتاب و
+
+212
+00:21:01,740 --> 00:21:06,080
+الامتحانات و النشاطات هذا سؤال طلابي دايما بسألوني
+
+213
+00:21:06,080 --> 00:21:12,380
+يعني فاللي بحكيه كالتالي الأصل الواحد يحضر
+
+214
+00:21:12,380 --> 00:21:19,020
+المحاضرةإذا في عنده أسئلة يسأل بالذات أنا بحكي
+
+215
+00:21:19,020 --> 00:21:26,180
+تجربتي على مواضيع المناع إنه لما كنت طالب كنت أغلب
+
+216
+00:21:26,180 --> 00:21:30,680
+الأستاذ وأقوله أقعد أسأل وبالأخير أقوله مافهمتش
+
+217
+00:21:30,680 --> 00:21:35,940
+فكون الواحد إنه مايفهمش مش عيب ويمكن فيه غلط في
+
+218
+00:21:35,940 --> 00:21:42,860
+طريقة الطرح أو في طريقة الوصففالمهم أن الواحد
+
+219
+00:21:42,860 --> 00:21:46,160
+يسأل، بقول إذا الطلاب ما سألوش واحدة من اثنتين
+
+220
+00:21:46,160 --> 00:21:51,220
+تانية، يا إما فاهمين كل إشي ومافيش إشي، يا إما أنه
+
+221
+00:21:51,220 --> 00:21:54,540
+مش فاهمين إشي، فإن شاء الله تكونوا أنتم الفاهمين
+
+222
+00:21:54,540 --> 00:22:02,040
+الكويسين، بالنسبة الآن طريقة الامتحاناتراح نتفق
+
+223
+00:22:02,040 --> 00:22:06,580
+عليها بشكل أدق أنا بفضل يكون في First وSecond
+
+224
+00:22:06,580 --> 00:22:12,380
+Midterm وFinal فبدها تقسيم الدرجات وتقسيم الأشياء
+
+225
+00:22:12,380 --> 00:22:19,940
+بالنسبة شو تدرسوه بقول الإلم يعني زي المحيط زي
+
+226
+00:22:19,940 --> 00:22:25,150
+الكمية هائلة من الإلم وإلم الله لا ينفذعلم الله
+
+227
+00:22:25,150 --> 00:22:33,010
+يعني بتلاقوه أوسع من أي شيء الإنسان يعني ممكن
+
+228
+00:22:33,010 --> 00:22:37,690
+يعرفه، هيظل فيه مجهول، هيظل فيه أشياء تكتشف، هيظل
+
+229
+00:22:37,690 --> 00:22:42,210
+لكل واحد منكم دور إنه يستخدم عقله، يستخدم
+
+230
+00:22:42,210 --> 00:22:48,770
+إمكاناته، دائما يستخدم الواحد المنهج العلمي في نظر
+
+231
+00:22:48,770 --> 00:22:54,650
+للأشياء والحياة والدنيافأنا ما بسألكم بشكل المطلق
+
+232
+00:22:54,650 --> 00:23:01,630
+المطلق الأصل الواحد يركز في المحاضرات بس أنا كمان
+
+233
+00:23:01,630 --> 00:23:06,610
+من واجبي لما نكون في امتحان أني أفرقكم عن بعض أنه
+
+234
+00:23:06,610 --> 00:23:12,390
+مين أحسن ومين أسوأ، فلازم تتوقع أنه في أشياء يعني
+
+235
+00:23:12,390 --> 00:23:17,370
+إذا الموضوع ما حكيته في المحاضرة ولا موجود في
+
+236
+00:23:17,370 --> 00:23:21,800
+الكتاب، ما راح أجيبلكم إياهأما إذا موجود في الكتاب
+
+237
+00:23:21,800 --> 00:23:27,320
+والمرجع أو بكر في المحاضرة أو ماكانش في الكتاب بأي
+
+238
+00:23:27,320 --> 00:23:33,840
+جهتين فهو سؤال عادل للطلاب ولازم يكون توقعوا يعني
+
+239
+00:23:33,840 --> 00:23:42,780
+نسبة قليلة من الأسئلة تكون صعبة شو اسمه؟ يعني هسا
+
+240
+00:23:42,780 --> 00:23:47,840
+بتقعدوا تسأله بكفي ولا ما بكفي بقولبكفي ولا ما
+
+241
+00:23:47,840 --> 00:23:53,920
+بكفي، برجع الواحد للواحد منكم، بدك 95، 100 بالمية،
+
+242
+00:23:53,920 --> 00:23:57,780
+تكون الأول على الدفعة، بدك تبدأ الجهد أكبر، بدك
+
+243
+00:23:57,780 --> 00:24:05,700
+نجاح وستيرة، و الواحد يمشي حاله، فيش اسمه، يعني
+
+244
+00:24:05,700 --> 00:24:09,660
+ممكن يدرس المحاضرات، و أصلا ال slides تبعتي من
+
+245
+00:24:09,660 --> 00:24:16,960
+مرجع من الكتابالواحد لما في الطب كله لما يشوف مرجع
+
+246
+00:24:16,960 --> 00:24:23,000
+يمكن الكلام الصغير التفاصيل الدقيقة ما يبقى يلحقش
+
+247
+00:24:23,000 --> 00:24:27,260
+يقراها أو يفهمها أو كده إنما دائما الصور والـ
+
+248
+00:24:27,260 --> 00:24:32,160
+«بوكس» اللي بتكون فيها تعليقات هيكي أو فيها نقاط
+
+249
+00:24:32,160 --> 00:24:35,280
+واحد، اثنين، ثلاث، أربعة هذه الأشياء اللي الواحد
+
+250
+00:24:35,280 --> 00:24:41,210
+يركز عليها بالذات لأغراض الامتحاناتالأسئلة عن كيف
+
+251
+00:24:41,210 --> 00:24:45,730
+أدرس وما أدرس هي يخلّوني إياها يعني أنا بقول
+
+252
+00:24:45,730 --> 00:24:50,430
+بالأخير الواحد برجع إلىه وبعدين كل ما الواحد أو
+
+253
+00:24:50,430 --> 00:24:56,050
+الطالب أو الدكتور بعرف أكثر، مستوعب أكثر، عنده
+
+254
+00:24:56,050 --> 00:25:01,810
+يعني فهم أدق، يكون هو إنسان أحسن، يكون مرغوب أكثر،
+
+255
+00:25:01,810 --> 00:25:05,310
+يكون في أي مكان في العالم يبدو إياه يكون أحسن،
+
+256
+00:25:05,310 --> 00:25:12,890
+المهم الواحد يفهم المفاهيمالأسئلة، خلّينا نكمّل،
+
+257
+00:25:12,890 --> 00:25:21,730
+الكتاب، الشوفوا، الطب والعلم متداخل مع بعضه، ماشي،
+
+258
+00:25:21,730 --> 00:25:26,150
+فكل ما بتعرف أكتر، فتسهل عليك في أشياء أخرى،
+
+259
+00:25:26,150 --> 00:25:31,930
+والمهم أنك أنت تفهم المبادئ، يعني يفهم الواحد
+
+260
+00:25:31,930 --> 00:25:33,050
+الكلام اللي بيستخدمه
+
+261
+00:25:35,770 --> 00:25:42,630
+الأن في المقدمة في كتابكم النقطة الأساسية والأولى
+
+262
+00:25:42,630 --> 00:25:51,610
+أنه إحنا كـ Genetics اللي هي المادة الوراثة اللي
+
+263
+00:25:51,610 --> 00:25:57,670
+هي تصف كيف الصفات المميزة لأي إنسان أو كائن حي
+
+264
+00:25:57,670 --> 00:26:02,730
+تنتقل من الأباء للأبناء الـ
+
+265
+00:26:03,670 --> 00:26:09,250
+النظرة في كمية
+
+266
+00:26:09,250 --> 00:26:14,950
+المادة الوراثية بأكملها تسمى Genomics أو الـ
+
+267
+00:26:14,950 --> 00:26:21,030
+«جينوم» الـ «جينوم» يعني الـ «جين» هو المادة
+
+268
+00:26:21,030 --> 00:26:26,330
+الوراثية اللي بتكون قطعة من الـ «DNA» عادةً نسبياً
+
+269
+00:26:26,330 --> 00:26:34,050
+صغيرة بتمنقلها إلى أن تصبح بروتينفي قطعة الـ DNA
+
+270
+00:26:34,050 --> 00:26:37,910
+اللي بتتحول إلى Messenger RNA اللي راح تعطينا الـ
+
+271
+00:26:37,910 --> 00:26:42,430
+Protein اللي بالأخير بيكون في الجسم، هذه اللي هو
+
+272
+00:26:42,430 --> 00:26:49,930
+الـ Gene وبالتالي، يعني هناك حوالي، يعني بيقولوا
+
+273
+00:26:49,930 --> 00:26:57,250
+ما بين 20 إلى 25 ألف Gene في الـ DNA تبع الإنسان،
+
+274
+00:26:57,250 --> 00:27:06,450
+بنتقل الأمر إلى الـ Proteinsالنظرة إلى كل الـ DNA
+
+275
+00:27:06,450 --> 00:27:14,290
+بأكمله هناك نصبح نتكلم عن الـ Genomics فهذه ظواهر
+
+276
+00:27:14,290 --> 00:27:21,270
+بتكون مسؤولة عن أمراض طبعاً هي بالأول بتمطر الصفة
+
+277
+00:27:21,270 --> 00:27:26,590
+الورافية من الأب والأم إلى الأبناءولكن أيضًا بتكون
+
+278
+00:27:26,590 --> 00:27:32,770
+مسؤولة عن التسبب بالأمراض ونستخدمها لتشقيث أمراض
+
+279
+00:27:32,770 --> 00:27:35,950
+وأحيانًا كثيرة ممكن نستخدمها حتى في علاج الأمراض
+
+280
+00:27:35,950 --> 00:27:39,650
+هناك
+
+281
+00:27:39,650 --> 00:27:44,430
+استفادة من المادة الورافية مثلًا في الطب الشرعي
+
+282
+00:27:44,430 --> 00:27:50,250
+نستخدم جوانب الآن ورافية في هذه الفحوصات لإثبات
+
+283
+00:27:50,250 --> 00:27:57,970
+مثلًا الأبوة والـإنه فلان، أبو فلان أو وجود علاقات
+
+284
+00:27:57,970 --> 00:28:04,710
+مثلًا «لا سمح الله جثة لقيت وتم أخذ جزء من الـDNA»
+
+285
+00:28:04,710 --> 00:28:11,010
+وإذا شكينا إنه ممكن بطريقة فحص الـGenome نقول إن
+
+286
+00:28:11,010 --> 00:28:15,750
+هذا أقرب للعائلة الفلانية من العائلة الفلانيةهناك
+
+287
+00:28:15,750 --> 00:28:19,830
+جوانب في الـ Cancer Management السرطانات عبارة عن
+
+288
+00:28:19,830 --> 00:28:26,750
+خلل في الـ DNA جزء أساسي من التسبب فيها سواء
+
+289
+00:28:26,750 --> 00:28:33,250
+لتشفيص السرطان أو لعلاج السرطان مما يتحكم في عملية
+
+290
+00:28:33,250 --> 00:28:40,950
+نقل الأعضاء قضية الوراثة والـ Genome
+
+291
+00:28:40,950 --> 00:28:46,390
+والـ DNA وكذافهذه قضية يجب أن يكون هناك يعني
+
+292
+00:28:46,390 --> 00:28:50,850
+انتباه لها أنها تتدخل الآن في قضايا كثيرة القضايا
+
+293
+00:28:50,850 --> 00:28:56,390
+الطب في قضية التشخيص يعني الآن مثلا الـ COVID-19
+
+294
+00:28:56,390 --> 00:29:03,530
+هذا الوباء الأخير في العالم التشخيص الأدقله هو في
+
+295
+00:29:03,530 --> 00:29:09,810
+البحث عن الـ RNA تبع الفيروس في الـ Sample أو في
+
+296
+00:29:09,810 --> 00:29:15,700
+العينةفالفحص الـ PCR اللي كلمه كنت بسمع عنه لأنه
+
+297
+00:29:15,700 --> 00:29:19,980
+فيه طريقة فحص على وجود الالتهاب من خلال اثبات وجود
+
+298
+00:29:19,980 --> 00:29:26,620
+أجسام مضادة ضده فهي الـ PCR هذا عبارة عن تقنية من
+
+299
+00:29:26,620 --> 00:29:32,880
+الـ Genetics والـ Genomics وبنستخدمها كتير فالـ
+
+300
+00:29:32,880 --> 00:29:39,330
+يعني المطلوب أن يكون الإنسانالطبيب يفهم معنى الـ
+
+301
+00:29:39,330 --> 00:29:43,350
+«جين» والـ «جينوم» الـ «جين» قطعة واحدة بتعطينا
+
+302
+00:29:43,350 --> 00:29:48,310
+الـ «DNA» اللي بيعطينا الـ «RNA» اللي بيعطينا الـ
+
+303
+00:29:48,310 --> 00:29:53,750
+«بروتين» اللي بيعطينا المظهر الخارجي كل الأدة هذه
+
+304
+00:29:53,750 --> 00:30:01,530
+كاملة بمجملها تسمى «جينوم» فتراتيب الـ «DNA» هذه
+
+305
+00:30:01,530 --> 00:30:04,970
+قضية راح ناخدها بالتفصيل وهي قضية مهمة
+
+306
+00:30:10,120 --> 00:30:18,440
+وكأنواع للأمراض الوراثية ماشي طبعاً الآن الرأي
+
+307
+00:30:18,440 --> 00:30:24,280
+الأصح أن كل الأمراض وكل الظواهر عبارة عن تداخل ما
+
+308
+00:30:24,280 --> 00:30:28,240
+بين الوراثة والبيئةGenetic and Environmental
+
+309
+00:30:28,240 --> 00:30:35,020
+Pathogenesis يعني إلا يكون هناك مشاركةبين الوراثة
+
+310
+00:30:35,020 --> 00:30:41,800
+وبين البيئة لإعطاء المظاهر المختلفة هناك تفاوت بين
+
+311
+00:30:41,800 --> 00:30:49,920
+درجة تأثير البيئة وتأثير الوراثة يعني نفترض مثلًا
+
+312
+00:30:49,920 --> 00:30:56,710
+إنسانلم يتعرض للإشعاع، وإنسان اتعرض للإشعاع مادة
+
+313
+00:30:56,710 --> 00:31:00,750
+كيموية، إنسان اتعرض لها كمية قليلة أو كمية كثيرة
+
+314
+00:31:00,750 --> 00:31:06,830
+فيروس أو بكتيريا أو جرثومة أو حاجة اللي اتعرض
+
+315
+00:31:06,830 --> 00:31:10,090
+إليها ممكن ينصاب اللي ما اتعرضش إليها ممكن ينصبش
+
+316
+00:31:10,090 --> 00:31:15,330
+هذا الجانب، بس حتى في مثلًا اتعرض إنسان لجرثومة
+
+317
+00:31:15,330 --> 00:31:20,380
+معينة هناك فيه اختلافات ورافية بين البشرتجعل
+
+318
+00:31:20,380 --> 00:31:27,260
+الإنسان مقاوم وفيه إنسان معرض للمرض الشديد فدائماً
+
+319
+00:31:27,260 --> 00:31:32,460
+هناك تداخل بين الجوانب الوراثية والجوانب البيئية
+
+320
+00:31:32,460 --> 00:31:39,880
+أنواع الأمراض الوراثية أو التي تتدخل فيها الوراثة
+
+321
+00:31:39,880 --> 00:31:46,160
+نقسمها على ثلاث درجات بشكل كبير كمقدمة هناك
+
+322
+00:31:46,160 --> 00:31:51,900
+الـChromosomal Diseases يعنيعبارة عن مرض ناتج عن
+
+323
+00:31:51,900 --> 00:32:02,580
+خلل في قطعة كاملة بسمى الـ Chromosome ماشي، الجسم
+
+324
+00:32:02,580 --> 00:32:08,660
+الملون، الـ Chromosome بسمى الجسم الملون هو قطعة
+
+325
+00:32:08,660 --> 00:32:14,180
+من الـ DNA وراح نأخذ ترتيبها أكبر
+
+326
+00:32:17,260 --> 00:32:23,580
+بحيث أنه نوقف عليها أمراض تنتيجة، يعني مشهو أشهر
+
+327
+00:32:23,580 --> 00:32:28,060
+واحد الـDown Syndrome، «تيرنر»، «كلاينفلتر»، Super
+
+328
+00:32:28,060 --> 00:32:34,520
+Women Diseases، يعني فيه أو جزء من الـChromosome،
+
+329
+00:32:34,520 --> 00:32:39,800
+بس هي بيكون عدد الجينات فيها كبير التجارب من دل هي
+
+330
+00:32:39,800 --> 00:32:44,680
+أمثلة على ما يسمى Single Gene Disorder، يعني عبارة
+
+331
+00:32:44,680 --> 00:32:50,700
+عن مرضلفقط جين واحد فبتسمى الـ Mandelian
+
+332
+00:32:50,700 --> 00:32:55,360
+Inheritance أو بتكون ليه ساعد ومتنحي عندما نتكلم
+
+333
+00:32:55,360 --> 00:33:02,220
+عن خلل أو مرض نتيجة تغير في جين واحد من كل هذه
+
+334
+00:33:02,220 --> 00:33:06,720
+الأعداد الجينات ولكن الغالبية الأضمة من كثير من
+
+335
+00:33:06,720 --> 00:33:12,860
+الأمراض عبارة عن أمراض تكون عدد كبير من الجينات
+
+336
+00:33:12,860 --> 00:33:17,620
+مشتركة فيهافمثلًا، الرابو القصبي الـ Bronchial
+
+337
+00:33:17,620 --> 00:33:23,580
+asthma بكون حوالي ما لا يقل عن خمسين جين داخل في
+
+338
+00:33:23,580 --> 00:33:33,240
+قضية التسبب بهذا المرض وتدخل فيها دواهر أخرى، راح
+
+339
+00:33:33,240 --> 00:33:37,100
+نتكلم فيها علم التخلق اللي هي الـ Epigenetics اللي
+
+340
+00:33:37,100 --> 00:33:42,340
+هي إنه يشترك عدد كبيرمن الجينات بطريقة متناغمة
+
+341
+00:33:42,340 --> 00:33:47,980
+للتسبب بمرض معين زي السكري والضغط والربو ومشاكل
+
+342
+00:33:47,980 --> 00:33:53,960
+القلب وكثير من الأمراض تجد أن ورافتها ليست ورافة
+
+343
+00:33:53,960 --> 00:33:58,900
+منديلية تابعة للجين واحد إنما يكون عدد كبير من
+
+344
+00:33:58,900 --> 00:34:06,540
+الجينات فيهامن المراجع، يعني الآن الطب يتغير
+
+345
+00:34:06,540 --> 00:34:11,540
+ومصادر العلوم تتغير وإذا الـ «نت» مفتوح وهو مصدر
+
+346
+00:34:11,540 --> 00:34:19,780
+تاري جداً بالمعلومات الطبية الـ «نت» يعني عيبه أو
+
+347
+00:34:19,780 --> 00:34:25,440
+مشكلته أنه بدك ترجع لمراجع جيدةأحيانًا هناك الغرث
+
+348
+00:34:25,440 --> 00:34:31,880
+والسمين هناك المفيد وهناك الضار هناك يعني هي أدوات
+
+349
+00:34:31,880 --> 00:34:38,260
+تسمح لأي إنسان أن يذكر ما يريد أو أي عالم بالقسيم
+
+350
+00:34:38,260 --> 00:34:42,660
+يدّعي ما يريد ولكن يجب أن يدقق الإنسان ويستخدم
+
+351
+00:34:42,660 --> 00:34:48,620
+المراجع الجيدة فمن الـ من الـ
+
+352
+00:34:51,110 --> 00:34:56,350
+من الأشياء اللي الآن موجودة هناك يعني جهود دا
+
+353
+00:34:56,350 --> 00:35:01,630
+مثلا، دا بالنسبة لقضية الـ الـ بالنسبة لقضية
+
+354
+00:35:01,630 --> 00:35:05,450
+المراجع، ممكن يستفيد منها طبعاً التكنولوجيا الآن
+
+355
+00:35:05,450 --> 00:35:10,410
+متقدمة جداً ويعني إذا الإنسان يكون مشبوك على الـ
+
+356
+00:35:10,410 --> 00:35:15,190
+«نت» ويكون يصل على هذه المراجع يكون يستطيع أن يرجع
+
+357
+00:35:15,190 --> 00:35:22,720
+منهالكثير من المقالات والمراجع علمية نسميها الـ
+
+358
+00:35:22,720 --> 00:35:26,520
+PubMed اللي هو تبع الـ National Institutes of
+
+359
+00:35:26,520 --> 00:35:33,280
+Health هناك خدمة مفتوحة لعامة البشر في أنه يدخل
+
+360
+00:35:33,280 --> 00:35:37,480
+على الموقع هذا ويقرأ عن الأمراض والمقالات العلمية
+
+361
+00:35:37,480 --> 00:35:42,560
+الداخلة فيها بس إذا الواحد انتبه في نفس هذا الموقع
+
+362
+00:35:43,040 --> 00:35:46,060
+هناك الأمم اللي هو الـ Online Mandelian
+
+363
+00:35:46,060 --> 00:35:51,780
+Inheritance in Man Database فهذه قاعدة بيانات عن
+
+364
+00:35:51,780 --> 00:35:58,040
+جميع الأمراض الوراثية المندلية اللي هي المقصود
+
+365
+00:35:58,040 --> 00:36:06,360
+أنها بتكون تابعة لجين واحد فقط فهذه يعني مهمة
+
+366
+00:36:06,360 --> 00:36:13,080
+وأحيانًا يعني ممكنيعني تكون مرجع لأي واحد مننا إذا
+
+367
+00:36:13,080 --> 00:36:19,180
+أجته حالة يعني معقدة أو حالة لم يعرف عنها أو ممكن
+
+368
+00:36:19,180 --> 00:36:24,620
+يكون هو يفتشف أول حالة وهناك حاولنا نتكلم على
+
+369
+00:36:24,620 --> 00:36:31,180
+أمراض شععة في منطقتنا لأن كل منطقة في العالم لها
+
+370
+00:36:31,180 --> 00:36:39,060
+خصائص أو أمراض تكون أكتريعني شيوعاً وذلك بسبب
+
+371
+00:36:39,060 --> 00:36:43,960
+طريقة الزواج، زواج الأقارب قضية التعرض في البيئة
+
+372
+00:36:43,960 --> 00:36:50,540
+لأشياء معينة فالتكنولوجيا الآن مفيدة ومتقدمة
+
+373
+00:36:50,540 --> 00:36:53,700
+وسنتكلم
+
+374
+00:36:53,700 --> 00:36:59,900
+على الـ Genomics هناك دراسات تنظر إلى كل الجينات
+
+375
+00:36:59,900 --> 00:37:08,890
+بمجملها في الإنسان وهناكمؤثرات يعني ما فوق التخلق
+
+376
+00:37:08,890 --> 00:37:13,310
+أو ما يسموه علم التخلق اللي هو إنه اتأثر على عدد
+
+377
+00:37:13,310 --> 00:37:20,010
+كبير من الجينات بطريقة يعني كما يقال مثل قاعد
+
+378
+00:37:20,010 --> 00:37:28,070
+أوكسترا فنية بإشارة منه مجموعة لعبين سواء على
+
+379
+00:37:28,070 --> 00:37:32,980
+الطبل ولا المزمار ولا الكمان ولا البيانوبتلاقي
+
+380
+00:37:32,980 --> 00:37:37,000
+مجموعة كبيرة بتشتغل ومجموعة بتسكت وبعد شوية بغير
+
+381
+00:37:37,000 --> 00:37:44,520
+كدا وبغير كدا هذه الـ Epigenetics هناك من التقدم
+
+382
+00:37:44,520 --> 00:37:51,580
+العلمي ما يدرس مثلا تأثير مجمل الميكروبات التي
+
+383
+00:37:51,580 --> 00:37:55,740
+تعيش على الإنسانفي الجلد، في القناة الهضمية، على
+
+384
+00:37:55,740 --> 00:38:01,800
+الجهاز التنفسي هذا يسمى الـMicrobiome يعني هي أنت
+
+385
+00:38:01,800 --> 00:38:07,200
+لا تدرس فقط جرثومة واحدة أو وجودها أو من عدمه أو
+
+386
+00:38:07,200 --> 00:38:11,740
+دور جرثومة معينة بقدر ما أنك أنت تدرس جميع
+
+387
+00:38:11,740 --> 00:38:17,560
+الجرافيم فيها
+
+388
+00:38:18,470 --> 00:38:27,590
+في الـ Exposomes والـ Protosomes يعني الآن
+
+389
+00:38:27,590 --> 00:38:32,690
+حكينا في حوالي تقريبًا 25 ألف جين في جسم الإنسان
+
+390
+00:38:32,690 --> 00:38:42,770
+في أمراض تكون نتيجة مثلًا تنشيط أو خمول أو تغيير
+
+391
+00:38:42,770 --> 00:38:48,650
+في أدد كبير من الجينات فما هي الألية؟ليتم فيها
+
+392
+00:38:48,650 --> 00:38:55,450
+تغيير عدد كبير من الجينات بحيث أنه يعني كمثال
+
+393
+00:38:55,450 --> 00:39:01,770
+ذكرته يتخيلها الواحد إنه الجينات كلهم عبارة عن
+
+394
+00:39:01,770 --> 00:39:07,670
+أوكسترا عبارة عن مجموعة فنية فبتلاقي عدد كبير من
+
+395
+00:39:07,670 --> 00:39:15,150
+الجينات المتداخلة حتى يعني تقنعك الموسيقى وينبسط
+
+396
+00:39:15,150 --> 00:39:23,580
+الإنسان فيهابدها تكون عداد كبيرة من الجينات
+
+397
+00:39:23,580 --> 00:39:33,120
+سواء يتم تفعيلها أو يتم تخفيضها ويعني تثبيتها فهذا
+
+398
+00:39:33,120 --> 00:39:38,740
+التفاوت فيه وقاله يعني آليات معينة الـ «DNA
+
+399
+00:39:38,740 --> 00:39:44,070
+methylation» الـ «Chromatin changes»فيها آليات
+
+400
+00:39:44,070 --> 00:39:52,070
+معينة فهي الـ Epigenetics تدخل في طرائق التحكم في
+
+401
+00:39:52,070 --> 00:39:57,470
+شغل الجينات بشكل كلي وليس على مستوى الجين واحد
+
+402
+00:39:57,470 --> 00:40:03,270
+فقط، يعني أرجو أن أكون يعني الفكرة وصلة، راح ناخد
+
+403
+00:40:03,270 --> 00:40:08,630
+تفاصيلها أكتر يعني هذه كلها مقدمات على أنه الوضع
+
+404
+00:40:08,630 --> 00:40:15,630
+الحالي فيعلم الوراثة هناك يجب أن يعتمد الأمر على
+
+405
+00:40:15,630 --> 00:40:22,570
+سهل دقيق ابتداءً للـ DNA وتركيبه وشغله وكيف بيتم
+
+406
+00:40:22,570 --> 00:40:30,430
+ثم على التفاعل الجينات الكثيرة مع بعضها وتفاعلها
+
+407
+00:40:30,430 --> 00:40:34,670
+مع البيئة وتفاعلها مع الأمراض والاستفادات الأخرى
+
+408
+00:40:35,360 --> 00:40:41,160
+أظن هذه آخر slide للمفاهيم اللي مطلوب إنه نحكيها
+
+409
+00:40:41,160 --> 00:40:49,320
+في المقدمة الأولى وإذا في أي سؤال مكتوب أو حد بيحب
+
+410
+00:40:49,320 --> 00:40:58,580
+يعلق أنا حاضر إذا في إشي مش واضح في
+
+411
+00:40:58,580 --> 00:40:59,720
+أي سؤال؟
+
+412
+00:41:07,160 --> 00:41:16,980
+الـ Exposomes عبارة عن مجموعة ما تعرض له أي إنسان
+
+413
+00:41:16,980 --> 00:41:26,660
+يعني الأمر مربوط في التقنيات المخدرية لإمكانية
+
+414
+00:41:26,660 --> 00:41:33,840
+الفحص على شيء معين يعني زمان كنا إذا بدنا نفحص عن
+
+415
+00:41:33,840 --> 00:41:40,040
+جين معينبدّك تجيب الفحص المخبري عن هذا الشيء محدد
+
+416
+00:41:40,040 --> 00:41:44,880
+تحديدًا فأذكر
+
+417
+00:41:44,880 --> 00:41:50,640
+الـ «إيميل» تبعي بدكم تاخدوه وأعطيت الـ «CR»
+
+418
+00:41:50,640 --> 00:41:55,580
+والدكاترة اللي معاكم تليفوناتي إذا حد بحب يتواصل
+
+419
+00:41:55,580 --> 00:42:02,460
+فيه الـ «إيميل» الـ «واتس آب» أنا حاطر فالـ
+
+420
+00:42:03,920 --> 00:42:08,960
+الـ Gene هو شغل واحدة الـ Microbe الفلاني شغل
+
+421
+00:42:08,960 --> 00:42:16,020
+واحدة وجود مثلًا دوة معينة، غذاء معين، مادة معينة
+
+422
+00:42:16,020 --> 00:42:24,220
+في البيئة هاي يعني شغل واحدة فلما أنا آجي أدرس
+
+423
+00:42:24,220 --> 00:42:28,840
+مجموع الـ Genes كلها هيك بضرب واحدة على جهاز أشوف
+
+424
+00:42:28,840 --> 00:42:34,400
+الـ 20 ألفجين مع بعض بسميه إن أنا درست الـ Genome
+
+425
+00:42:34,400 --> 00:42:40,880
+الـ Microbiome برضه بطريقة واحدة فأس واحد بدرس
+
+426
+00:42:40,880 --> 00:42:46,040
+مجمل أنواع البكتيريا بتعرفوا أي مكان في جسم
+
+427
+00:42:46,040 --> 00:42:54,940
+الإنسان الجرافيم الضارة هي الأكثر حوالي 4، 5% 90%،
+
+428
+00:42:54,940 --> 00:43:00,680
+95%، 99% عبارة عن جرافيم مفيدةبس حتى الجيرانفينيوم
+
+429
+00:43:00,680 --> 00:43:07,040
+المفيدة هذه اللي ساكنة علينا ودوانا في كده الآن في
+
+430
+00:43:07,040 --> 00:43:12,440
+وسائل دراسية لدراسة مجملها كلها مرة واحدة، طجة
+
+431
+00:43:12,440 --> 00:43:16,620
+واحدة، تدرسهم كلهم، هذا بيسموها Microbiome فالآن
+
+432
+00:43:16,620 --> 00:43:22,300
+الـ Exposomes عبارة من الـ Exposure يعني اللي هو
+
+433
+00:43:22,300 --> 00:43:28,640
+ما تم التعرض له، نتكلم يعنيبدل ما بدي أقول فلان
+
+434
+00:43:28,640 --> 00:43:33,260
+أكل بروتين كثير وماكلش تهون كثير وأكل Carbohydrate
+
+435
+00:43:33,260 --> 00:43:38,120
+وسط وكذا الفرق بين مجمل ما يتعرض له الإنسان من
+
+436
+00:43:38,120 --> 00:43:44,260
+سواء المركبات، من أدوية، من أشياء بيئية تؤثر في
+
+437
+00:43:44,260 --> 00:43:48,100
+المرض أحيانًا، هذه بيسموها Exposons وهذه من
+
+438
+00:43:48,100 --> 00:43:53,520
+المفاهيم الحديثة بسبب التقدم التكنولوجي في إمكانية
+
+439
+00:43:53,520 --> 00:43:56,440
+إن أنا أبحث عليها، ماشي؟
+
+440
+00:43:58,970 --> 00:44:05,190
+الآن أظن صارت الساعة عشرة إن شاء الله موعدنا يوم
+
+441
+00:44:05,190 --> 00:44:11,200
+الأربعة راح نبدأ إن شاء الله على الوقتويكون يعني
+
+442
+00:44:11,200 --> 00:44:19,100
+الأمور أصبت إن شاء الله بفضل الدكتور … أنا بعتبر
+
+443
+00:44:19,100 --> 00:44:22,960
+الدكتور أحمد و الـ «Class Representative» الـ
+
+444
+00:44:22,960 --> 00:44:30,740
+«سيشن» تبعت الـ الـ الـ «سيشن» هذه، احنا آه كويسة،
+
+445
+00:44:30,740 --> 00:44:35,790
+راح نضلنا نتقابل وإن شاء الله موجودين يعنياللي
+
+446
+00:44:35,790 --> 00:44:41,130
+بحبه أنه الآن خلصنا الفصل الأول في الكتاب وديت
+
+447
+00:44:41,130 --> 00:44:46,250
+الـsoft copy التبعته تطلعوا عليها اقرؤوا إذا حدا
+
+448
+00:44:46,250 --> 00:44:50,790
+في أول جزء المحاضرة القادمة راح نتكلم إن شاء الله
+
+449
+00:44:50,790 --> 00:44:55,570
+عن إذا في حد عنده أي أسئلة
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/Sczornve5Hk_raw.json b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/Sczornve5Hk_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..e523962febd5c8879383e2388dcfaf5851ae1964
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/Sczornve5Hk_raw.json
@@ -0,0 +1 @@
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11296, 1975, 4587, 2288, 33604, 14407, 11933, 15730, 11331, 28259, 8978, 5551, 12610, 10874, 11622, 38207, 9673, 5016, 46958, 25720, 25062, 18513, 46007, 12602, 39319, 8717, 2655, 4117, 19528, 36145, 13412, 16606, 21984, 18871, 11933, 15730, 8978, 11331, 3215, 43242, 3224, 36632, 5551, 3794, 19986, 37977], "avg_logprob": -0.18023256212472916, "compression_ratio": 1.6595744680851063, "no_speech_prob": 3.248453140258789e-05, "words": [{"start": 2674.45, "end": 2675.79, "word": "اللي", "probability": 0.919921875}, {"start": 2675.79, "end": 2676.45, "word": " بحبه", "probability": 0.975830078125}, {"start": 2676.45, "end": 2677.11, "word": " أنه", "probability": 0.80615234375}, {"start": 2677.11, "end": 2677.51, "word": " الآن", "probability": 0.632080078125}, {"start": 2677.51, "end": 2678.05, "word": " خلصنا", "probability": 0.9190673828125}, {"start": 2678.05, "end": 2678.47, "word": " الفصل", "probability": 0.732421875}, {"start": 2678.47, "end": 2678.81, "word": " الأول", "probability": 0.967041015625}, {"start": 2678.81, "end": 2678.99, "word": " في", "probability": 0.92041015625}, {"start": 2678.99, "end": 2680.03, "word": " الكتاب", "probability": 0.99365234375}, {"start": 2680.03, "end": 2681.13, "word": " وديت", "probability": 0.6717122395833334}, {"start": 2681.13, "end": 2681.71, "word": " الـsoft", "probability": 0.6966959635416666}, {"start": 2681.71, "end": 2682.11, "word": " copy", "probability": 0.92333984375}, {"start": 2682.11, "end": 2682.81, "word": " التبعته", "probability": 0.7763671875}, {"start": 2682.81, "end": 2683.95, "word": " تطلعوا", "probability": 0.8214111328125}, {"start": 2683.95, "end": 2684.53, "word": " عليها", "probability": 0.994873046875}, {"start": 2684.53, "end": 2685.47, "word": " اقرؤوا", "probability": 0.761767578125}, {"start": 2685.47, "end": 2685.95, "word": " إذا", "probability": 0.716552734375}, {"start": 2685.95, "end": 2686.25, "word": " حدا", "probability": 0.81787109375}, {"start": 2686.25, "end": 2686.53, "word": " في", "probability": 0.95751953125}, {"start": 2686.53, "end": 2687.13, "word": " أول", "probability": 0.9658203125}, {"start": 2687.13, "end": 2687.45, "word": " جزء", "probability": 0.9938151041666666}, {"start": 2687.45, "end": 2688.03, "word": " المحاضرة", "probability": 0.9681396484375}, {"start": 2688.03, "end": 2688.63, "word": " القادمة", "probability": 0.9925130208333334}, {"start": 2688.63, "end": 2689.17, "word": " راح", "probability": 0.939208984375}, {"start": 2689.17, "end": 2689.79, "word": " نتكلم", "probability": 0.991943359375}, {"start": 2689.79, "end": 2690.41, "word": " إن", "probability": 0.7119140625}, {"start": 2690.41, "end": 2690.57, "word": " شاء", "probability": 0.9716796875}, {"start": 2690.57, "end": 2690.79, "word": " الله", "probability": 0.95947265625}, {"start": 2690.79, "end": 2691.39, "word": " عن", "probability": 0.97021484375}, {"start": 2691.39, "end": 2694.15, "word": " إذا", "probability": 0.617919921875}, {"start": 2694.15, 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\ No newline at end of file
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/Sczornve5Hk_raw.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/Sczornve5Hk_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..8668b8ec492e54ceda7e6c60773cdb0672a80804
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/Sczornve5Hk_raw.srt
@@ -0,0 +1,1796 @@
+1
+00:00:00,000 --> 00:00:02,980
+باسم الله الرحمن الرحيم، الحمد لله رب العالمين
+
+2
+00:00:02,980 --> 00:00:10,280
+ونفس الله سبحانه وتعالى أن يوفقكم جميعًا لمعرفة
+
+3
+00:00:10,280 --> 00:00:14,260
+هذا العلم يعني بالنسبة للوراثة، بالذات في الفصل
+
+4
+00:00:14,260 --> 00:00:23,520
+هذا حقيقة الوراثة جانب مهم كتير، وجانب اللي دخل في
+
+5
+00:00:23,520 --> 00:00:27,220
+جوانب
+
+6
+00:00:27,220 --> 00:00:33,430
+كتير، طبية سواءفي الأمراض، في الفهمها، في التسبب
+
+7
+00:00:33,430 --> 00:00:40,730
+فيها إلى دخل في قضية الآن كيف نفهم الـ Mechanisms،
+
+8
+00:00:40,730 --> 00:00:48,610
+الـ Diseases كيف بتتم تشخيصها، كيف بتتم علاجها إلى
+
+9
+00:00:48,610 --> 00:00:54,080
+دخل في أشياء كتيرةبحب أني دايما أسمع حتى لو بعض
+
+10
+00:00:54,080 --> 00:01:02,120
+الطلاب يعني إذا بحبوا يستوقفوا، بحبوا يعني بحبوا
+
+11
+00:01:02,120 --> 00:01:06,120
+يسألوا سؤال أو إذا فيه إشي مش واضح لأن الكلام
+
+12
+00:01:06,120 --> 00:01:10,760
+واضح، حابب أسمع، يعني بحب تكون فيه مشاركة يعني حتى
+
+13
+00:01:10,760 --> 00:01:17,370
+لو كان فيه جانب مش واضح، نتكلم عنهالكلام واضح
+
+14
+00:01:17,370 --> 00:01:24,130
+للجميع غير الأستاذ الدكتور أحمد سامعيني ما شاء
+
+15
+00:01:24,130 --> 00:01:30,930
+الله 80 طالب وطالبة في حد عنده ملاحظةإن شاء الله
+
+16
+00:01:30,930 --> 00:01:35,990
+المرات القادمة الأمور التقنية بتكون تنحل أكثر
+
+17
+00:01:35,990 --> 00:01:40,810
+وفعلا أنا حريص على إنه نسجل المحاضرات عشان بأي وقت
+
+18
+00:01:40,810 --> 00:01:49,230
+عندكم حدا بدي يشاهدها بوقت آخر بيصير بس إذا يعني
+
+19
+00:01:50,850 --> 00:01:56,670
+الأن تفاصيل ال course بالنسبة لشو طريقة التقييم
+
+20
+00:01:56,670 --> 00:02:00,890
+وكيف طريقة الامتحانات ان شاء الله قريبا بعطيكم
+
+21
+00:02:00,890 --> 00:02:05,650
+إياها الأخت عايشة الدكتورة عايشة بدها إشي كان واحد
+
+22
+00:02:05,650 --> 00:02:12,050
+بدى يفتح ال telephone أو ال microphone طيب
+
+23
+00:02:14,120 --> 00:02:19,940
+بالنسبة لمواضيع الوراثة أنا رجعت للكتاب اللي هو
+
+24
+00:02:19,940 --> 00:02:24,320
+«Genetics in Medicine» «Thompson and Thomson»
+
+25
+00:02:24,320 --> 00:02:30,540
+وحقيقةً مرجع ممتاز يمكن العيب الأساسي اللي فيه أنه
+
+26
+00:02:30,540 --> 00:02:35,080
+يمكن المعلومات اللي فيه أكثر من اللي الإنسان
+
+27
+00:02:35,080 --> 00:02:41,570
+بيحتاجها أحيانًا كطبيب عام أو كطالب طبوبالتالي مش
+
+28
+00:02:41,570 --> 00:02:46,730
+غلط الواحد يتعرض للمعلومات وإن كان يعني مش ضروري
+
+29
+00:02:46,730 --> 00:02:51,610
+للحفظ وللمتحانات بقدر ما أنه أنا بهمني أن يكون
+
+30
+00:02:51,610 --> 00:03:00,170
+الواحد فاهم المفاهيم تكون أكثر بالنسبة
+
+31
+00:03:00,170 --> 00:03:09,650
+لمواضيع ال .. بالنسبة لمواضيعتاريخية علم المناعة
+
+32
+00:03:09,650 --> 00:03:13,190
+الحديث اللي إحنا بنعرفه يعني أنا بظن إنه في
+
+33
+00:03:13,190 --> 00:03:21,190
+التاريخ دائماً هناك يعني معرفته تساعد الواحد لفهم
+
+34
+00:03:21,190 --> 00:03:25,750
+كيف الأمر اتطور بهذا الشكل اللي إحنا موجودين فيه
+
+35
+00:03:25,750 --> 00:03:32,030
+الآن وبالتالي يعني من أوائل الناس اللي يمكن كلكم
+
+36
+00:03:32,030 --> 00:03:36,980
+سمع عنه قضية «مندرن»مندل بالنسبة للمناعة يعني
+
+37
+00:03:36,980 --> 00:03:42,560
+يعتبر هو أبو المناعة أبو الحساسية آسف، أبو الوراثة
+
+38
+00:03:42,560 --> 00:03:53,160
+فالمندل بالـ 1800 كان راهب نمساوي وعمل تجارب يعني
+
+39
+00:03:53,160 --> 00:03:59,800
+حط أو يعني لاحظ من خلالها ملاحظات معينة كانت مهمة
+
+40
+00:03:59,800 --> 00:04:07,230
+كثير لوضع أسس في قضية الوراثةبدنا نتذكر إنه الآن
+
+41
+00:04:07,230 --> 00:04:12,070
+إحنا بنحكي عن تاريخ مختلف تماماً عن ما إحنا نعرفه
+
+42
+00:04:12,070 --> 00:04:19,390
+الآن يعني الـ DNA والبروتين والـ enzymes وكيف
+
+43
+00:04:19,390 --> 00:04:26,930
+الجسم بتعامل ويتفاعل هذه كانت وقتها مجهولة، فيعني
+
+44
+00:04:26,930 --> 00:04:32,570
+كانت تجاربه هي من الملاحظات الأولى لقضية الوراثة
+
+45
+00:04:35,120 --> 00:04:40,600
+و«أرتيبولد جارود» كمان يعني وصف في اللي هو الـ
+
+46
+00:04:40,600 --> 00:04:46,720
+«الكابتو بيورينيا» «الكابتو نيوريا» «الكابتون
+
+47
+00:04:46,720 --> 00:04:52,160
+نيوريا» اللي هو Emperor in Aerometabolism كان من
+
+48
+00:04:52,160 --> 00:04:56,660
+أوائل الناس اللي وصفه في سنة الـ1902 يعني هذه
+
+49
+00:04:56,660 --> 00:05:03,120
+بدايات العلم الوراثة وكانت بشكل يعنينعتبرها الآن
+
+50
+00:05:03,120 --> 00:05:09,500
+مجهولة يعني كانت طواهر بتكلموا عنها إذا في أي
+
+51
+00:05:09,500 --> 00:05:13,040
+أسئلة أنا بتكلم مرة بالعربي و مرة بالإنجليزي للأسف
+
+52
+00:05:13,040 --> 00:05:15,860
+هيك الواحد طالع ينقربها إذا إن شاء الله الكلام
+
+53
+00:05:15,860 --> 00:05:21,400
+واضح وإذا أي حد بيشوف أي ملاحظة لشيء مش واضح من أي
+
+54
+00:05:21,400 --> 00:05:24,720
+ناحية يحكي وممكن نعيد إن شاء الله
+
+55
+00:05:29,420 --> 00:05:36,080
+بالنسبة لـ «تجارب
+
+56
+00:05:36,080 --> 00:05:40,720
+مندل» يعني هو كانت على الـ «بازيلا» على الـ «بيز»
+
+57
+00:05:40,720 --> 00:05:46,640
+وكان يعني عملت تجارب اللي هي كانت أول مرة بتظهر
+
+58
+00:05:46,640 --> 00:05:51,320
+للبشر قضية إنه فيه صفات سائدة وفيه صفات متنحية فيه
+
+59
+00:05:51,320 --> 00:05:56,940
+dominant traits، فيه recessive traitsفمثلًا،
+
+60
+00:05:56,940 --> 00:06:00,900
+بالنسبة وأجرى تجارب على مدى سنين طويلة في أنواع
+
+61
+00:06:00,900 --> 00:06:07,140
+كثيرة وكان يلقح النباتات بطريقة خاصة بحيث إنه كان
+
+62
+00:06:07,140 --> 00:06:13,980
+النبات إذا وردته بنفسجية أو وردته بيضة فالصفة
+
+63
+00:06:13,980 --> 00:06:20,600
+الساعدة هي اللون البنفسجي إذا كان طريقة النمو يعني
+
+64
+00:06:20,600 --> 00:06:23,500
+محوري والـ
+
+65
+00:06:25,140 --> 00:06:31,660
+الوردة بتيجي في طرف النبتة ولا على جنبها فإنه اللي
+
+66
+00:06:31,660 --> 00:06:36,160
+على الجنب هو الصفة السائدة إذا كانت كلون الحبّة
+
+67
+00:06:36,160 --> 00:06:42,140
+البازيلة صفراء أو خضراء إنه اللون الأصفر هو السائد
+
+68
+00:06:42,140 --> 00:06:50,000
+إذا كانت مستديرة ولا مجعلة ومكسرة فإنها تكون
+
+69
+00:06:50,000 --> 00:06:57,880
+مستديرة وواضحة فهي هذا الصفة السائدةالشكل الحبة أو
+
+70
+00:06:57,880 --> 00:07:11,740
+القطف البازلاء أنه يكون يعني منفوخ أو مضموم فلمّا
+
+71
+00:07:11,740 --> 00:07:17,440
+يعمل مثل هذه التجارب فانتبه إلى أنه فيه صفات سائدة
+
+72
+00:07:17,440 --> 00:07:23,160
+وفيه صفات متنحية هل هي طويلة أو قصيرة فمن خلال هذه
+
+73
+00:07:23,160 --> 00:07:29,420
+التجاربكانت أول ملاحظة لبنسان أنه فيه مواد أو صفات
+
+74
+00:07:29,420 --> 00:07:38,740
+وراثية إشي ساعد وإشي متنحن سبحان الله، بقول الحفظ
+
+75
+00:07:38,740 --> 00:07:45,240
+الجيد لمندل في تجاربه هذه قضية أنه، يعني وهذه
+
+76
+00:07:45,240 --> 00:07:50,540
+بمحدث صدفة كما يقال إنه كل الصفات اللي درسها
+
+77
+00:07:50,540 --> 00:07:55,990
+بالشكل المختلف بهذه الطريقةكانت على كروموزومات
+
+78
+00:07:55,990 --> 00:08:02,150
+منفصلة يعني لو حدث إنه كان الصفة على صفتين أو أكثر
+
+79
+00:08:02,150 --> 00:08:05,810
+على نفس الكروموزوم كانت هذه الظاهرة ما راح تتم
+
+80
+00:08:05,810 --> 00:08:13,910
+بهذا الوضوح فكانت تجارب مندل يعني عبارة عن تجارب
+
+81
+00:08:13,910 --> 00:08:19,810
+زراعية في بيته وذكر نتائجها في دراسة بعد عشرات
+
+82
+00:08:19,810 --> 00:08:25,930
+آلاف التجارب أو عدد كبير من التجاربكانت النتيجة
+
+83
+00:08:25,930 --> 00:08:32,130
+أنها أهملت وفقدت وما .. يعني ما اهتمولها العلماء
+
+84
+00:08:32,130 --> 00:08:36,310
+وما أخذوا فيها لحد تقريبًا بعد أربعين سنة أو
+
+85
+00:08:36,310 --> 00:08:41,010
+ثلاثين سنة من وفاته واكتشفوها مرة ثانية وأثبتت
+
+86
+00:08:41,010 --> 00:08:48,530
+وكانت من الأشياء اللي يعني كانت بدايات فهم علم
+
+87
+00:08:48,530 --> 00:08:55,240
+الوراثةإذا حد بيحب يسأل، يسأل، يعني إذا في شيء مش
+
+88
+00:08:55,240 --> 00:09:00,260
+واضح، ممكن نتكلم، بحب أسمع، إن شاء الله الشرح
+
+89
+00:09:00,260 --> 00:09:12,000
+واضح، حد بيحب يتكلم، أهي صار فيه مئة مشارك، دكتور
+
+90
+00:09:12,000 --> 00:09:16,700
+أحمد واضح، عشان بلاش ندخل و بعدين، تمام، دكتور،
+
+91
+00:09:16,700 --> 00:09:25,470
+اتوقع اللهالـ يعني من بدايات الفهمنة
+
+92
+00:09:25,470 --> 00:09:30,110
+للوراثة كانت في تجارب زي التجارب من دلوقت وهي قضية
+
+93
+00:09:30,110 --> 00:09:33,870
+الساعد والمتنحي بالنسبة للمادة الوراثية وإن هناك
+
+94
+00:09:33,870 --> 00:09:38,910
+صفات مختلفة ودا أشخاص أخرون المفهوم أنهم يلهم
+
+95
+00:09:38,910 --> 00:09:45,980
+أدوار كبيرة مثلا Lamarckفي قضية أن البيئة هي التي
+
+96
+00:09:45,980 --> 00:09:53,940
+تغير وملاحظته لطول رقبة الزرافة إنه تعطيها أفضلية
+
+97
+00:09:53,940 --> 00:10:00,840
+في الطبيعة أو الحياة أن تكون رقبتها أطول فكانت هذه
+
+98
+00:10:00,840 --> 00:10:05,780
+أفكار بالقرن التاسع عشر، الف وثمانميةوحقيقةً يعني
+
+99
+00:10:05,780 --> 00:10:09,420
+حتى في أواخر تلك الأهد أنه بدأنا نستخدم
+
+100
+00:10:09,420 --> 00:10:13,040
+المايكروسكوبات والـ Microbiology ونفهم التركيب
+
+101
+00:10:13,040 --> 00:10:18,360
+الكيموي للمراكبات بما فيها يعني قضايا الـ
+
+102
+00:10:18,360 --> 00:10:23,540
+Carbohydrate والبروتينات والدهون وبداية القرن
+
+103
+00:10:23,540 --> 00:10:30,220
+الأشرين تم بداية اكتشاف الـ DNA الـ Deoxynucleic
+
+104
+00:10:30,220 --> 00:10:35,980
+Acid يعني اللي هي الأحماض النوويةوالأحماض النووية
+
+105
+00:10:35,980 --> 00:10:44,100
+يعني اللي راح نخدها بشكل تفصيلي أكثر في الأشرينات
+
+106
+00:10:44,100 --> 00:10:52,840
+والثلاثينات الـ Thymine يعني كأحد القواعد
+
+107
+00:10:52,840 --> 00:10:57,880
+النيتروجينية الـ Nitrogen Bases للـ DNA كان
+
+108
+00:10:57,880 --> 00:11:02,750
+اكتشافه والاسم هذا لأنهما استطاعوا يعزلوا كمية
+
+109
+00:11:02,750 --> 00:11:07,250
+كافية منه إلا من الـ Thymus تبعت الـ Thor ففي
+
+110
+00:11:07,250 --> 00:11:13,810
+دراسات معينة كانوا يعزلوا كمادة كيموية وكان هناك
+
+111
+00:11:13,810 --> 00:11:19,590
+بداية يعني إعجاب وفهم للتركيب الكيموي للمواد
+
+112
+00:11:19,590 --> 00:11:24,830
+العضويةفبما فيها الـ Carbohydrate والبروتين والـ
+
+113
+00:11:24,830 --> 00:11:33,450
+Lipids والأحماض النووية الـ Nucleic Acids كان هناك
+
+114
+00:11:33,450 --> 00:11:38,990
+أحيانًا اشتباه إنه وراثة أو نقل الصفات من الأباء
+
+115
+00:11:38,990 --> 00:11:45,450
+للأبناء والأمهات للأبناء إنه من خلال نفترض
+
+116
+00:11:45,450 --> 00:11:54,260
+البروتين نفسه ولكن تجارببعد ذلك، وفهم أكبر للكيميا
+
+117
+00:11:54,260 --> 00:11:59,600
+الأضوية والكيميا الحيوية أصبح هناك فهم لقضية أن
+
+118
+00:11:59,600 --> 00:12:07,060
+الـ «DNA» والمادة الوراثية هي التي تشكل المادة
+
+119
+00:12:07,060 --> 00:12:11,720
+الوراثية وهي التي تسبب نقل الصفات الوراثية كيف هذا
+
+120
+00:12:11,720 --> 00:12:17,550
+الأمر بتتم؟كيف هذا الأمر يعني ربنا وضعه فينا هذه
+
+121
+00:12:17,550 --> 00:12:22,110
+هي القضية اللي أخذنا وقت طويل حتى استطعنا نفهمها
+
+122
+00:12:22,110 --> 00:12:26,870
+وكان جزء أساسي منها كما الآن كلكم تعرفوا في سنة
+
+123
+00:12:26,870 --> 00:12:34,750
+الـ54 أو بالخمسينات واتسون والكريك أعطوامبادع على
+
+124
+00:12:34,750 --> 00:12:40,590
+تركيب الـ DNA باستخدام الـ X-Ray وCrystalography
+
+125
+00:12:40,590 --> 00:12:44,910
+وتقنيات معينة كلما يمتلك الإنسان أو العالم أو
+
+126
+00:12:44,910 --> 00:12:50,910
+الطبيب أو العالم أو البشر أدوات يمكنهم بها دراسة
+
+127
+00:12:50,910 --> 00:12:58,210
+أشياء أخرى ممكن الواحد يكتشف ملاحظات جديدة يعني
+
+128
+00:12:58,210 --> 00:13:04,340
+بدنا ندرس الفضاء، بدنا نجيبمناظير تليسكوب أقوى،
+
+129
+00:13:04,340 --> 00:13:08,140
+بدنا ندرس تركيب الأشياء الأصغر في أصغر في أصغر،
+
+130
+00:13:08,140 --> 00:13:12,020
+بدنا مايكروسكوبات أقوى، أول مايكروسكوب، مايكروسكوب
+
+131
+00:13:12,020 --> 00:13:15,640
+الضوئي، يعني الـ Light Microscopy، بالكثير،
+
+132
+00:13:15,640 --> 00:13:20,230
+بيجيبلك ألف مرةالآن فيه Electron Microscopy ممكن
+
+133
+00:13:20,230 --> 00:13:24,850
+توصل لحد 500 إلى 100 إلى مليون 500 ألف مرة إلى
+
+134
+00:13:24,850 --> 00:13:30,650
+مليون فكل ما بتشوف عندك أدوات أدق تستطيع إنك تشوف
+
+135
+00:13:30,650 --> 00:13:38,610
+أشياء أعمق الفهم للبروتين والـDNA والتركيب كيفية
+
+136
+00:13:38,610 --> 00:13:48,480
+التحكم في الصفات الوراثيةخلّت العلماء يدخلوا
+
+137
+00:13:48,480 --> 00:13:53,400
+في برنامج كلف بلايين الدولارات والأموال الكبيرة
+
+138
+00:13:53,400 --> 00:14:01,320
+اللي هي الـ Human Genome Project سنة التسعينبدأت
+
+139
+00:14:01,320 --> 00:14:08,400
+قضية أنه يعني راح ناخد بعدين تفاصيل كيف يعني الـ
+
+140
+00:14:08,400 --> 00:14:12,460
+DNA يكون مسؤول عن المادة الوراثية كيف الـ DNA بوصل
+
+141
+00:14:12,460 --> 00:14:16,260
+أنه يعطينا الـ Protein اللي هو المظهر الخارجي
+
+142
+00:14:16,260 --> 00:14:22,950
+للمادة الحية فكان اقتراح أحدهمإنه نبدأ نقرأ اللي
+
+143
+00:14:22,950 --> 00:14:29,070
+هي أحرف المادة الوراثية لإنسان طبعاً بدت التجارب
+
+144
+00:14:29,070 --> 00:14:34,590
+أسبق من ذلك في إنه يقرأوا المادة الوراثية لحيوانات
+
+145
+00:14:34,590 --> 00:14:40,490
+أدق أو أصغر أو كده فكان أول DNA Sequence يعني
+
+146
+00:14:40,490 --> 00:14:45,130
+Whole Genome Sequence لكل المادة الوراثية هي
+
+147
+00:14:45,130 --> 00:14:50,360
+لذبابة الفاكهة الـ Drosophilaهذا من فترة أقدم
+
+148
+00:14:50,360 --> 00:14:55,400
+عشرات سنين يعني عشان كان عشرين سنة أول حيوان ولكن
+
+149
+00:14:55,400 --> 00:14:59,780
+قرروا بعدين إنه ليش ما نقرأ الـ DNA تبع الإنسان
+
+150
+00:14:59,780 --> 00:15:09,120
+كله فبدت من سنة 1990 وهي قراءة التسعة بلايين حرف
+
+151
+00:15:09,120 --> 00:15:14,320
+من القواعد النيتروجينية في الـ DNAالـ DNA يعني
+
+152
+00:15:14,320 --> 00:15:18,520
+اللي هو راح ناخد تركيبه بعد شوية بتفصيل أكتر هو
+
+153
+00:15:18,520 --> 00:15:28,380
+الكتاب الأصلي أو المرجع في تكوّل الإنسان وبالتالي
+
+154
+00:15:28,380 --> 00:15:36,640
+أتأمل إنه صورة واضحة اللي هي إنه يعني هنا تفاصيل
+
+155
+00:15:36,640 --> 00:15:40,540
+المراحل
+
+156
+00:15:40,540 --> 00:15:47,730
+اللي تمتبذكر هنا إنه أول أجهزة
+
+157
+00:15:47,730 --> 00:15:51,330
+في فضية عمل قراءة الـ Sequence واللي بيسموها الـ
+
+158
+00:15:51,330 --> 00:15:59,070
+Sequencers كانت بطيئة وأن في كل مرحلة، وبدأت بعد
+
+159
+00:15:59,070 --> 00:16:04,980
+تقدم التكنولوجييعني هذه الصورة بتوصل لحد عام 2003
+
+160
+00:16:04,980 --> 00:16:11,020
+من 1990 وكيف بدوا فيه قراءة المادة الوراثية
+
+161
+00:16:11,020 --> 00:16:16,520
+لحيوانات مختلفة الآن الأجهزة التي تعمل عملية
+
+162
+00:16:16,520 --> 00:16:24,280
+القراءة الـ Nucleotides هذه أكفأ بملايين المرات
+
+163
+00:16:24,760 --> 00:16:30,880
+يعني كل فترة وفترة القدرة على قراءة الـ Sequences
+
+164
+00:16:30,880 --> 00:16:36,280
+هدولة تصبح أسرع بكثير ورح نتكلم على هذه الجوالب
+
+165
+00:16:36,280 --> 00:16:41,780
+فالآن إنك تعمل طبعاً أول Human Genome Project يعني
+
+166
+00:16:41,780 --> 00:16:48,060
+ذكرت إنه تكلف تقريباً
+
+167
+00:16:48,060 --> 00:16:55,740
+مليارات أشتغل فيه حوالي مش أقل من ألفمختبر في
+
+168
+00:16:55,740 --> 00:17:01,040
+العالم في جامعات مختلفة تم فيها محاولة قراءة
+
+169
+00:17:01,040 --> 00:17:08,900
+الأحرف تبع في الـ DNA لشخص معين وبالتالي يعني قعد
+
+170
+00:17:08,900 --> 00:17:13,940
+مش أقل من يمكن أقل شويه من عشر سنوات وهم يقرأوا
+
+171
+00:17:13,940 --> 00:17:21,420
+فيها الآن كل هذا الجهد في خلال يومين، ثلاثة في
+
+172
+00:17:21,420 --> 00:17:26,010
+أجهزة بتقرار بالكاملكان بالأول يعني هناك تقدم رهيب
+
+173
+00:17:26,010 --> 00:17:29,190
+في
+
+174
+00:17:29,190 --> 00:17:35,670
+أسئلة إن شاء الله الأمور واضحة يعني هذه مقدمة
+
+175
+00:17:35,670 --> 00:17:42,770
+نعتبرها تاريخية لألم الوراثة الحالي طبعاً بتدخل في
+
+176
+00:17:42,770 --> 00:17:48,930
+كثير من الجوانب ويله تطبيقات مهمة في جوانب كثيرة
+
+177
+00:17:48,930 --> 00:17:52,750
+في أسئلة إذا حد عنده سؤال
+
+178
+00:17:57,990 --> 00:18:07,490
+كيف حالكم؟ إن شاء الله كويسين، طيب، في
+
+179
+00:18:07,490 --> 00:18:08,170
+أسئلة؟
+
+180
+00:18:13,750 --> 00:18:17,950
+زي عاديتك يا دكتور يعني طبعًا يا شباب ويا أخواتنا
+
+181
+00:18:17,950 --> 00:18:22,010
+إذا حد بيحب يسأل يمكنه يعني يستخدم إشارة رفع اليد
+
+182
+00:18:22,010 --> 00:18:26,750
+أو يبعت تعليج يعني إشارة رفع اليد طبعًا دكتور ممكن
+
+183
+00:18:26,750 --> 00:18:30,850
+يعمله «unmute» ويسمع منه السؤال عاد مشارك أه أنا
+
+184
+00:18:30,850 --> 00:18:34,170
+حاليًا على الـ «Zoom» حاطة «full screen» يعني
+
+185
+00:18:34,170 --> 00:18:38,490
+مابيينش معاه إذا حد بيحب يتكلم الـ«chats» 32
+
+186
+00:18:42,470 --> 00:18:45,970
+طيب، هنا في واحد بيطلب أشرح عن حالي، إن شاء الله
+
+187
+00:18:45,970 --> 00:18:52,370
+بكلمكم، خلّيها بالأخيرة شوية طيب،
+
+188
+00:18:52,370 --> 00:18:58,910
+في حد بيحب يسأل عن المادة العلمية، يعني أنا الـ
+
+189
+00:18:58,910 --> 00:19:02,350
+أنا شخصياً
+
+190
+00:19:02,350 --> 00:19:07,470
+يعني أهلي في الأصل منظفة الغربية، من ارتاح طول كرم
+
+191
+00:19:07,470 --> 00:19:11,930
+كنا في الكويت، أخرج جامعة الكويتذهبت للولايات
+
+192
+00:19:11,930 --> 00:19:15,650
+المتحدة الأمريكية وطلصت باطنية ومناعة وحساسية
+
+193
+00:19:15,650 --> 00:19:20,010
+المناعة والحساسية الـ Genetics تبعتها من أصعب
+
+194
+00:19:20,010 --> 00:19:27,910
+المواد الوراثة يعني المفاهيم يعني الـ حتى الواحد
+
+195
+00:19:27,910 --> 00:19:33,710
+يفهم توقعاً المناعة والحساسية ولا الوراثة بدي يكون
+
+196
+00:19:33,710 --> 00:19:41,760
+فاهمة فاهم دقيق بما فيها الـ الـ الـ الـالمبادئ
+
+197
+00:19:41,760 --> 00:19:47,280
+العلمية إلها من تراكيب كيميا حيوية كيف تشتغل
+
+198
+00:19:47,280 --> 00:19:54,420
+ونهايتها كيف بتأثر على البني آدمفأنا International
+
+199
+00:19:54,420 --> 00:19:57,900
+Fellow للـ American Academy of Allergy, Asthma and
+
+200
+00:19:57,900 --> 00:20:04,320
+Immunology الـ Epigenetics والـ Genetics والـ الـ
+
+201
+00:20:04,320 --> 00:20:08,120
+Genetics للـ Immune System صراحة من أعقد المواضيع
+
+202
+00:20:08,120 --> 00:20:14,500
+والموضوع كله سهل بالنسبالي أنا بشتغل فيه كمان
+
+203
+00:20:14,500 --> 00:20:18,180
+مستشار في اللجنة الأردنية لدعم الـ أنا استغلت في
+
+204
+00:20:18,180 --> 00:20:21,550
+جامعة الـعلوم التكنولوجيا الأردنية في كلية الطب
+
+205
+00:20:21,550 --> 00:20:27,650
+وكلية التقنيات الطبية أستاذ مشارك وأنا مستشار في
+
+206
+00:20:27,650 --> 00:20:32,810
+لجنة الأردنية لدعم القطاع الصحي في غزة لجنة في
+
+207
+00:20:32,810 --> 00:20:39,410
+النقابات الصحية في الأردن متخصصين في دعم القطاع
+
+208
+00:20:39,410 --> 00:20:45,220
+الصحي في غزة نشرف على تدريب أطباء في الأردنيعني
+
+209
+00:20:45,220 --> 00:20:49,280
+إحنا كلنا شعب واحد و أم واحدة و أنا بشرفني و
+
+210
+00:20:49,280 --> 00:20:58,860
+بسعدني أني أكون أقدر أساعدكم الآن بالنسبة كيفية
+
+211
+00:20:58,860 --> 00:21:01,740
+الدراسات الدراسة من الـ slides و لا من الكتاب و
+
+212
+00:21:01,740 --> 00:21:06,080
+الامتحانات و النشاطات هذا سؤال طلابي دايما بسألوني
+
+213
+00:21:06,080 --> 00:21:12,380
+يعني فاللي بحكيه كالتالي الأصل الواحد يحضر
+
+214
+00:21:12,380 --> 00:21:19,020
+المحاضرةإذا في عنده أسئلة يسأل بالذات أنا بحكي
+
+215
+00:21:19,020 --> 00:21:26,180
+تجربتي على مواضيع المناع إنه لما كنت طالب كنت أغلب
+
+216
+00:21:26,180 --> 00:21:30,680
+الأستاذ وأقوله أقعد أسأل وبالأخير أقوله مافهمتش
+
+217
+00:21:30,680 --> 00:21:35,940
+فكون الواحد إنه مايفهمش مش عيب ويمكن فيه غلط في
+
+218
+00:21:35,940 --> 00:21:42,860
+طريقة الطرح أو في طريقة الوصففالمهم أن الواحد
+
+219
+00:21:42,860 --> 00:21:46,160
+يسأل، بقول إذا الطلاب ما سألوش واحدة من اثنتين
+
+220
+00:21:46,160 --> 00:21:51,220
+تانية، يا إما فاهمين كل إشي ومافيش إشي، يا إما أنه
+
+221
+00:21:51,220 --> 00:21:54,540
+مش فاهمين إشي، فإن شاء الله تكونوا أنتم الفاهمين
+
+222
+00:21:54,540 --> 00:22:02,040
+الكويسين، بالنسبة الآن طريقة الامتحاناتراح نتفق
+
+223
+00:22:02,040 --> 00:22:06,580
+عليها بشكل أدق أنا بفضل يكون في First وSecond
+
+224
+00:22:06,580 --> 00:22:12,380
+Midterm وFinal فبدها تقسيم الدرجات وتقسيم الأشياء
+
+225
+00:22:12,380 --> 00:22:19,940
+بالنسبة شو تدرسوه بقول الإلم يعني زي المحيط زي
+
+226
+00:22:19,940 --> 00:22:25,150
+الكمية هائلة من الإلم وإلم الله لا ينفذعلم الله
+
+227
+00:22:25,150 --> 00:22:33,010
+يعني بتلاقوه أوسع من أي شيء الإنسان يعني ممكن
+
+228
+00:22:33,010 --> 00:22:37,690
+يعرفه، هيظل فيه مجهول، هيظل فيه أشياء تكتشف، هيظل
+
+229
+00:22:37,690 --> 00:22:42,210
+لكل واحد منكم دور إنه يستخدم عقله، يستخدم
+
+230
+00:22:42,210 --> 00:22:48,770
+إمكاناته، دائما يستخدم الواحد المنهج العلمي في نظر
+
+231
+00:22:48,770 --> 00:22:54,650
+للأشياء والحياة والدنيافأنا ما بسألكم بشكل المطلق
+
+232
+00:22:54,650 --> 00:23:01,630
+المطلق الأصل الواحد يركز في المحاضرات بس أنا كمان
+
+233
+00:23:01,630 --> 00:23:06,610
+من واجبي لما نكون في امتحان أني أفرقكم عن بعض أنه
+
+234
+00:23:06,610 --> 00:23:12,390
+مين أحسن ومين أسوأ، فلازم تتوقع أنه في أشياء يعني
+
+235
+00:23:12,390 --> 00:23:17,370
+إذا الموضوع ما حكيته في المحاضرة ولا موجود في
+
+236
+00:23:17,370 --> 00:23:21,800
+الكتاب، ما راح أجيبلكم إياهأما إذا موجود في الكتاب
+
+237
+00:23:21,800 --> 00:23:27,320
+والمرجع أو بكر في المحاضرة أو ماكانش في الكتاب بأي
+
+238
+00:23:27,320 --> 00:23:33,840
+جهتين فهو سؤال عادل للطلاب ولازم يكون توقعوا يعني
+
+239
+00:23:33,840 --> 00:23:42,780
+نسبة قليلة من الأسئلة تكون صعبة شو اسمه؟ يعني هسا
+
+240
+00:23:42,780 --> 00:23:47,840
+بتقعدوا تسأله بكفي ولا ما بكفي بقولبكفي ولا ما
+
+241
+00:23:47,840 --> 00:23:53,920
+بكفي، برجع الواحد للواحد منكم، بدك 95، 100 بالمية،
+
+242
+00:23:53,920 --> 00:23:57,780
+تكون الأول على الدفعة، بدك تبدأ الجهد أكبر، بدك
+
+243
+00:23:57,780 --> 00:24:05,700
+نجاح وستيرة، و الواحد يمشي حاله، فيش اسمه، يعني
+
+244
+00:24:05,700 --> 00:24:09,660
+ممكن يدرس المحاضرات، و أصلا ال slides تبعتي من
+
+245
+00:24:09,660 --> 00:24:16,960
+مرجع من الكتابالواحد لما في الطب كله لما يشوف مرجع
+
+246
+00:24:16,960 --> 00:24:23,000
+يمكن الكلام الصغير التفاصيل الدقيقة ما يبقى يلحقش
+
+247
+00:24:23,000 --> 00:24:27,260
+يقراها أو يفهمها أو كده إنما دائما الصور والـ
+
+248
+00:24:27,260 --> 00:24:32,160
+«بوكس» اللي بتكون فيها تعليقات هيكي أو فيها نقاط
+
+249
+00:24:32,160 --> 00:24:35,280
+واحد، اثنين، ثلاث، أربعة هذه الأشياء اللي الواحد
+
+250
+00:24:35,280 --> 00:24:41,210
+يركز عليها بالذات لأغراض الامتحاناتالأسئلة عن كيف
+
+251
+00:24:41,210 --> 00:24:45,730
+أدرس وما أدرس هي يخلّوني إياها يعني أنا بقول
+
+252
+00:24:45,730 --> 00:24:50,430
+بالأخير الواحد برجع إلىه وبعدين كل ما الواحد أو
+
+253
+00:24:50,430 --> 00:24:56,050
+الطالب أو الدكتور بعرف أكثر، مستوعب أكثر، عنده
+
+254
+00:24:56,050 --> 00:25:01,810
+يعني فهم أدق، يكون هو إنسان أحسن، يكون مرغوب أكثر،
+
+255
+00:25:01,810 --> 00:25:05,310
+يكون في أي مكان في العالم يبدو إياه يكون أحسن،
+
+256
+00:25:05,310 --> 00:25:12,890
+المهم الواحد يفهم المفاهيمالأسئلة، خلّينا نكمّل،
+
+257
+00:25:12,890 --> 00:25:21,730
+الكتاب، الشوفوا، الطب والعلم متداخل مع بعضه، ماشي،
+
+258
+00:25:21,730 --> 00:25:26,150
+فكل ما بتعرف أكتر، فتسهل عليك في أشياء أخرى،
+
+259
+00:25:26,150 --> 00:25:31,930
+والمهم أنك أنت تفهم المبادئ، يعني يفهم الواحد
+
+260
+00:25:31,930 --> 00:25:33,050
+الكلام اللي بيستخدمه
+
+261
+00:25:35,770 --> 00:25:42,630
+الأن في المقدمة في كتابكم النقطة الأساسية والأولى
+
+262
+00:25:42,630 --> 00:25:51,610
+أنه إحنا كـ Genetics اللي هي المادة الوراثة اللي
+
+263
+00:25:51,610 --> 00:25:57,670
+هي تصف كيف الصفات المميزة لأي إنسان أو كائن حي
+
+264
+00:25:57,670 --> 00:26:02,730
+تنتقل من الأباء للأبناء الـ
+
+265
+00:26:03,670 --> 00:26:09,250
+النظرة في كمية
+
+266
+00:26:09,250 --> 00:26:14,950
+المادة الوراثية بأكملها تسمى Genomics أو الـ
+
+267
+00:26:14,950 --> 00:26:21,030
+«جينوم» الـ «جينوم» يعني الـ «جين» هو المادة
+
+268
+00:26:21,030 --> 00:26:26,330
+الوراثية اللي بتكون قطعة من الـ «DNA» عادةً نسبياً
+
+269
+00:26:26,330 --> 00:26:34,050
+صغيرة بتمنقلها إلى أن تصبح بروتينفي قطعة الـ DNA
+
+270
+00:26:34,050 --> 00:26:37,910
+اللي بتتحول إلى Messenger RNA اللي راح تعطينا الـ
+
+271
+00:26:37,910 --> 00:26:42,430
+Protein اللي بالأخير بيكون في الجسم، هذه اللي هو
+
+272
+00:26:42,430 --> 00:26:49,930
+الـ Gene وبالتالي، يعني هناك حوالي، يعني بيقولوا
+
+273
+00:26:49,930 --> 00:26:57,250
+ما بين 20 إلى 25 ألف Gene في الـ DNA تبع الإنسان،
+
+274
+00:26:57,250 --> 00:27:06,450
+بنتقل الأمر إلى الـ Proteinsالنظرة إلى كل الـ DNA
+
+275
+00:27:06,450 --> 00:27:14,290
+بأكمله هناك نصبح نتكلم عن الـ Genomics فهذه ظواهر
+
+276
+00:27:14,290 --> 00:27:21,270
+بتكون مسؤولة عن أمراض طبعاً هي بالأول بتمطر الصفة
+
+277
+00:27:21,270 --> 00:27:26,590
+الورافية من الأب والأم إلى الأبناءولكن أيضًا بتكون
+
+278
+00:27:26,590 --> 00:27:32,770
+مسؤولة عن التسبب بالأمراض ونستخدمها لتشقيث أمراض
+
+279
+00:27:32,770 --> 00:27:35,950
+وأحيانًا كثيرة ممكن نستخدمها حتى في علاج الأمراض
+
+280
+00:27:35,950 --> 00:27:39,650
+هناك
+
+281
+00:27:39,650 --> 00:27:44,430
+استفادة من المادة الورافية مثلًا في الطب الشرعي
+
+282
+00:27:44,430 --> 00:27:50,250
+نستخدم جوانب الآن ورافية في هذه الفحوصات لإثبات
+
+283
+00:27:50,250 --> 00:27:57,970
+مثلًا الأبوة والـإنه فلان، أبو فلان أو وجود علاقات
+
+284
+00:27:57,970 --> 00:28:04,710
+مثلًا «لا سمح الله جثة لقيت وتم أخذ جزء من الـDNA»
+
+285
+00:28:04,710 --> 00:28:11,010
+وإذا شكينا إنه ممكن بطريقة فحص الـGenome نقول إن
+
+286
+00:28:11,010 --> 00:28:15,750
+هذا أقرب للعائلة الفلانية من العائلة الفلانيةهناك
+
+287
+00:28:15,750 --> 00:28:19,830
+جوانب في الـ Cancer Management السرطانات عبارة عن
+
+288
+00:28:19,830 --> 00:28:26,750
+خلل في الـ DNA جزء أساسي من التسبب فيها سواء
+
+289
+00:28:26,750 --> 00:28:33,250
+لتشفيص السرطان أو لعلاج السرطان مما يتحكم في عملية
+
+290
+00:28:33,250 --> 00:28:40,950
+نقل الأعضاء قضية الوراثة والـ Genome
+
+291
+00:28:40,950 --> 00:28:46,390
+والـ DNA وكذافهذه قضية يجب أن يكون هناك يعني
+
+292
+00:28:46,390 --> 00:28:50,850
+انتباه لها أنها تتدخل الآن في قضايا كثيرة القضايا
+
+293
+00:28:50,850 --> 00:28:56,390
+الطب في قضية التشخيص يعني الآن مثلا الـ COVID-19
+
+294
+00:28:56,390 --> 00:29:03,530
+هذا الوباء الأخير في العالم التشخيص الأدقله هو في
+
+295
+00:29:03,530 --> 00:29:09,810
+البحث عن الـ RNA تبع الفيروس في الـ Sample أو في
+
+296
+00:29:09,810 --> 00:29:15,700
+العينةفالفحص الـ PCR اللي كلمه كنت بسمع عنه لأنه
+
+297
+00:29:15,700 --> 00:29:19,980
+فيه طريقة فحص على وجود الالتهاب من خلال اثبات وجود
+
+298
+00:29:19,980 --> 00:29:26,620
+أجسام مضادة ضده فهي الـ PCR هذا عبارة عن تقنية من
+
+299
+00:29:26,620 --> 00:29:32,880
+الـ Genetics والـ Genomics وبنستخدمها كتير فالـ
+
+300
+00:29:32,880 --> 00:29:39,330
+يعني المطلوب أن يكون الإنسانالطبيب يفهم معنى الـ
+
+301
+00:29:39,330 --> 00:29:43,350
+«جين» والـ «جينوم» الـ «جين» قطعة واحدة بتعطينا
+
+302
+00:29:43,350 --> 00:29:48,310
+الـ «DNA» اللي بيعطينا الـ «RNA» اللي بيعطينا الـ
+
+303
+00:29:48,310 --> 00:29:53,750
+«بروتين» اللي بيعطينا المظهر الخارجي كل الأدة هذه
+
+304
+00:29:53,750 --> 00:30:01,530
+كاملة بمجملها تسمى «جينوم» فتراتيب الـ «DNA» هذه
+
+305
+00:30:01,530 --> 00:30:04,970
+قضية راح ناخدها بالتفصيل وهي قضية مهمة
+
+306
+00:30:10,120 --> 00:30:18,440
+وكأنواع للأمراض الوراثية ماشي طبعاً الآن الرأي
+
+307
+00:30:18,440 --> 00:30:24,280
+الأصح أن كل الأمراض وكل الظواهر عبارة عن تداخل ما
+
+308
+00:30:24,280 --> 00:30:28,240
+بين الوراثة والبيئةGenetic and Environmental
+
+309
+00:30:28,240 --> 00:30:35,020
+Pathogenesis يعني إلا يكون هناك مشاركةبين الوراثة
+
+310
+00:30:35,020 --> 00:30:41,800
+وبين البيئة لإعطاء المظاهر المختلفة هناك تفاوت بين
+
+311
+00:30:41,800 --> 00:30:49,920
+درجة تأثير البيئة وتأثير الوراثة يعني نفترض مثلًا
+
+312
+00:30:49,920 --> 00:30:56,710
+إنسانلم يتعرض للإشعاع، وإنسان اتعرض للإشعاع مادة
+
+313
+00:30:56,710 --> 00:31:00,750
+كيموية، إنسان اتعرض لها كمية قليلة أو كمية كثيرة
+
+314
+00:31:00,750 --> 00:31:06,830
+فيروس أو بكتيريا أو جرثومة أو حاجة اللي اتعرض
+
+315
+00:31:06,830 --> 00:31:10,090
+إليها ممكن ينصاب اللي ما اتعرضش إليها ممكن ينصبش
+
+316
+00:31:10,090 --> 00:31:15,330
+هذا الجانب، بس حتى في مثلًا اتعرض إنسان لجرثومة
+
+317
+00:31:15,330 --> 00:31:20,380
+معينة هناك فيه اختلافات ورافية بين البشرتجعل
+
+318
+00:31:20,380 --> 00:31:27,260
+الإنسان مقاوم وفيه إنسان معرض للمرض الشديد فدائماً
+
+319
+00:31:27,260 --> 00:31:32,460
+هناك تداخل بين الجوانب الوراثية والجوانب البيئية
+
+320
+00:31:32,460 --> 00:31:39,880
+أنواع الأمراض الوراثية أو التي تتدخل فيها الوراثة
+
+321
+00:31:39,880 --> 00:31:46,160
+نقسمها على ثلاث درجات بشكل كبير كمقدمة هناك
+
+322
+00:31:46,160 --> 00:31:51,900
+الـChromosomal Diseases يعنيعبارة عن مرض ناتج عن
+
+323
+00:31:51,900 --> 00:32:02,580
+خلل في قطعة كاملة بسمى الـ Chromosome ماشي، الجسم
+
+324
+00:32:02,580 --> 00:32:08,660
+الملون، الـ Chromosome بسمى الجسم الملون هو قطعة
+
+325
+00:32:08,660 --> 00:32:14,180
+من الـ DNA وراح نأخذ ترتيبها أكبر
+
+326
+00:32:17,260 --> 00:32:23,580
+بحيث أنه نوقف عليها أمراض تنتيجة، يعني مشهو أشهر
+
+327
+00:32:23,580 --> 00:32:28,060
+واحد الـDown Syndrome، «تيرنر»، «كلاينفلتر»، Super
+
+328
+00:32:28,060 --> 00:32:34,520
+Women Diseases، يعني فيه أو جزء من الـChromosome،
+
+329
+00:32:34,520 --> 00:32:39,800
+بس هي بيكون عدد الجينات فيها كبير التجارب من دل هي
+
+330
+00:32:39,800 --> 00:32:44,680
+أمثلة على ما يسمى Single Gene Disorder، يعني عبارة
+
+331
+00:32:44,680 --> 00:32:50,700
+عن مرضلفقط جين واحد فبتسمى الـ Mandelian
+
+332
+00:32:50,700 --> 00:32:55,360
+Inheritance أو بتكون ليه ساعد ومتنحي عندما نتكلم
+
+333
+00:32:55,360 --> 00:33:02,220
+عن خلل أو مرض نتيجة تغير في جين واحد من كل هذه
+
+334
+00:33:02,220 --> 00:33:06,720
+الأعداد الجينات ولكن الغالبية الأضمة من كثير من
+
+335
+00:33:06,720 --> 00:33:12,860
+الأمراض عبارة عن أمراض تكون عدد كبير من الجينات
+
+336
+00:33:12,860 --> 00:33:17,620
+مشتركة فيهافمثلًا، الرابو القصبي الـ Bronchial
+
+337
+00:33:17,620 --> 00:33:23,580
+asthma بكون حوالي ما لا يقل عن خمسين جين داخل في
+
+338
+00:33:23,580 --> 00:33:33,240
+قضية التسبب بهذا المرض وتدخل فيها دواهر أخرى، راح
+
+339
+00:33:33,240 --> 00:33:37,100
+نتكلم فيها علم التخلق اللي هي الـ Epigenetics اللي
+
+340
+00:33:37,100 --> 00:33:42,340
+هي إنه يشترك عدد كبيرمن الجينات بطريقة متناغمة
+
+341
+00:33:42,340 --> 00:33:47,980
+للتسبب بمرض معين زي السكري والضغط والربو ومشاكل
+
+342
+00:33:47,980 --> 00:33:53,960
+القلب وكثير من الأمراض تجد أن ورافتها ليست ورافة
+
+343
+00:33:53,960 --> 00:33:58,900
+منديلية تابعة للجين واحد إنما يكون عدد كبير من
+
+344
+00:33:58,900 --> 00:34:06,540
+الجينات فيهامن المراجع، يعني الآن الطب يتغير
+
+345
+00:34:06,540 --> 00:34:11,540
+ومصادر العلوم تتغير وإذا الـ «نت» مفتوح وهو مصدر
+
+346
+00:34:11,540 --> 00:34:19,780
+تاري جداً بالمعلومات الطبية الـ «نت» يعني عيبه أو
+
+347
+00:34:19,780 --> 00:34:25,440
+مشكلته أنه بدك ترجع لمراجع جيدةأحيانًا هناك الغرث
+
+348
+00:34:25,440 --> 00:34:31,880
+والسمين هناك المفيد وهناك الضار هناك يعني هي أدوات
+
+349
+00:34:31,880 --> 00:34:38,260
+تسمح لأي إنسان أن يذكر ما يريد أو أي عالم بالقسيم
+
+350
+00:34:38,260 --> 00:34:42,660
+يدّعي ما يريد ولكن يجب أن يدقق الإنسان ويستخدم
+
+351
+00:34:42,660 --> 00:34:48,620
+المراجع الجيدة فمن الـ من الـ
+
+352
+00:34:51,110 --> 00:34:56,350
+من الأشياء اللي الآن موجودة هناك يعني جهود دا
+
+353
+00:34:56,350 --> 00:35:01,630
+مثلا، دا بالنسبة لقضية الـ الـ بالنسبة لقضية
+
+354
+00:35:01,630 --> 00:35:05,450
+المراجع، ممكن يستفيد منها طبعاً التكنولوجيا الآن
+
+355
+00:35:05,450 --> 00:35:10,410
+متقدمة جداً ويعني إذا الإنسان يكون مشبوك على الـ
+
+356
+00:35:10,410 --> 00:35:15,190
+«نت» ويكون يصل على هذه المراجع يكون يستطيع أن يرجع
+
+357
+00:35:15,190 --> 00:35:22,720
+منهالكثير من المقالات والمراجع علمية نسميها الـ
+
+358
+00:35:22,720 --> 00:35:26,520
+PubMed اللي هو تبع الـ National Institutes of
+
+359
+00:35:26,520 --> 00:35:33,280
+Health هناك خدمة مفتوحة لعامة البشر في أنه يدخل
+
+360
+00:35:33,280 --> 00:35:37,480
+على الموقع هذا ويقرأ عن الأمراض والمقالات العلمية
+
+361
+00:35:37,480 --> 00:35:42,560
+الداخلة فيها بس إذا الواحد انتبه في نفس هذا الموقع
+
+362
+00:35:43,040 --> 00:35:46,060
+هناك الأمم اللي هو الـ Online Mandelian
+
+363
+00:35:46,060 --> 00:35:51,780
+Inheritance in Man Database فهذه قاعدة بيانات عن
+
+364
+00:35:51,780 --> 00:35:58,040
+جميع الأمراض الوراثية المندلية اللي هي المقصود
+
+365
+00:35:58,040 --> 00:36:06,360
+أنها بتكون تابعة لجين واحد فقط فهذه يعني مهمة
+
+366
+00:36:06,360 --> 00:36:13,080
+وأحيانًا يعني ممكنيعني تكون مرجع لأي واحد مننا إذا
+
+367
+00:36:13,080 --> 00:36:19,180
+أجته حالة يعني معقدة أو حالة لم يعرف عنها أو ممكن
+
+368
+00:36:19,180 --> 00:36:24,620
+يكون هو يفتشف أول حالة وهناك حاولنا نتكلم على
+
+369
+00:36:24,620 --> 00:36:31,180
+أمراض شععة في منطقتنا لأن كل منطقة في العالم لها
+
+370
+00:36:31,180 --> 00:36:39,060
+خصائص أو أمراض تكون أكتريعني شيوعاً وذلك بسبب
+
+371
+00:36:39,060 --> 00:36:43,960
+طريقة الزواج، زواج الأقارب قضية التعرض في البيئة
+
+372
+00:36:43,960 --> 00:36:50,540
+لأشياء معينة فالتكنولوجيا الآن مفيدة ومتقدمة
+
+373
+00:36:50,540 --> 00:36:53,700
+وسنتكلم
+
+374
+00:36:53,700 --> 00:36:59,900
+على الـ Genomics هناك دراسات تنظر إلى كل الجينات
+
+375
+00:36:59,900 --> 00:37:08,890
+بمجملها في الإنسان وهناكمؤثرات يعني ما فوق التخلق
+
+376
+00:37:08,890 --> 00:37:13,310
+أو ما يسموه علم التخلق اللي هو إنه اتأثر على عدد
+
+377
+00:37:13,310 --> 00:37:20,010
+كبير من الجينات بطريقة يعني كما يقال مثل قاعد
+
+378
+00:37:20,010 --> 00:37:28,070
+أوكسترا فنية بإشارة منه مجموعة لعبين سواء على
+
+379
+00:37:28,070 --> 00:37:32,980
+الطبل ولا المزمار ولا الكمان ولا البيانوبتلاقي
+
+380
+00:37:32,980 --> 00:37:37,000
+مجموعة كبيرة بتشتغل ومجموعة بتسكت وبعد شوية بغير
+
+381
+00:37:37,000 --> 00:37:44,520
+كدا وبغير كدا هذه الـ Epigenetics هناك من التقدم
+
+382
+00:37:44,520 --> 00:37:51,580
+العلمي ما يدرس مثلا تأثير مجمل الميكروبات التي
+
+383
+00:37:51,580 --> 00:37:55,740
+تعيش على الإنسانفي الجلد، في القناة الهضمية، على
+
+384
+00:37:55,740 --> 00:38:01,800
+الجهاز التنفسي هذا يسمى الـMicrobiome يعني هي أنت
+
+385
+00:38:01,800 --> 00:38:07,200
+لا تدرس فقط جرثومة واحدة أو وجودها أو من عدمه أو
+
+386
+00:38:07,200 --> 00:38:11,740
+دور جرثومة معينة بقدر ما أنك أنت تدرس جميع
+
+387
+00:38:11,740 --> 00:38:17,560
+الجرافيم فيها
+
+388
+00:38:18,470 --> 00:38:27,590
+في الـ Exposomes والـ Protosomes يعني الآن
+
+389
+00:38:27,590 --> 00:38:32,690
+حكينا في حوالي تقريبًا 25 ألف جين في جسم الإنسان
+
+390
+00:38:32,690 --> 00:38:42,770
+في أمراض تكون نتيجة مثلًا تنشيط أو خمول أو تغيير
+
+391
+00:38:42,770 --> 00:38:48,650
+في أدد كبير من الجينات فما هي الألية؟ليتم فيها
+
+392
+00:38:48,650 --> 00:38:55,450
+تغيير عدد كبير من الجينات بحيث أنه يعني كمثال
+
+393
+00:38:55,450 --> 00:39:01,770
+ذكرته يتخيلها الواحد إنه الجينات كلهم عبارة عن
+
+394
+00:39:01,770 --> 00:39:07,670
+أوكسترا عبارة عن مجموعة فنية فبتلاقي عدد كبير من
+
+395
+00:39:07,670 --> 00:39:15,150
+الجينات المتداخلة حتى يعني تقنعك الموسيقى وينبسط
+
+396
+00:39:15,150 --> 00:39:23,580
+الإنسان فيهابدها تكون عداد كبيرة من الجينات
+
+397
+00:39:23,580 --> 00:39:33,120
+سواء يتم تفعيلها أو يتم تخفيضها ويعني تثبيتها فهذا
+
+398
+00:39:33,120 --> 00:39:38,740
+التفاوت فيه وقاله يعني آليات معينة الـ «DNA
+
+399
+00:39:38,740 --> 00:39:44,070
+methylation» الـ «Chromatin changes»فيها آليات
+
+400
+00:39:44,070 --> 00:39:52,070
+معينة فهي الـ Epigenetics تدخل في طرائق التحكم في
+
+401
+00:39:52,070 --> 00:39:57,470
+شغل الجينات بشكل كلي وليس على مستوى الجين واحد
+
+402
+00:39:57,470 --> 00:40:03,270
+فقط، يعني أرجو أن أكون يعني الفكرة وصلة، راح ناخد
+
+403
+00:40:03,270 --> 00:40:08,630
+تفاصيلها أكتر يعني هذه كلها مقدمات على أنه الوضع
+
+404
+00:40:08,630 --> 00:40:15,630
+الحالي فيعلم الوراثة هناك يجب أن يعتمد الأمر على
+
+405
+00:40:15,630 --> 00:40:22,570
+سهل دقيق ابتداءً للـ DNA وتركيبه وشغله وكيف بيتم
+
+406
+00:40:22,570 --> 00:40:30,430
+ثم على التفاعل الجينات الكثيرة مع بعضها وتفاعلها
+
+407
+00:40:30,430 --> 00:40:34,670
+مع البيئة وتفاعلها مع الأمراض والاستفادات الأخرى
+
+408
+00:40:35,360 --> 00:40:41,160
+أظن هذه آخر slide للمفاهيم اللي مطلوب إنه نحكيها
+
+409
+00:40:41,160 --> 00:40:49,320
+في المقدمة الأولى وإذا في أي سؤال مكتوب أو حد بيحب
+
+410
+00:40:49,320 --> 00:40:58,580
+يعلق أنا حاضر إذا في إشي مش واضح في
+
+411
+00:40:58,580 --> 00:40:59,720
+أي سؤال؟
+
+412
+00:41:07,160 --> 00:41:16,980
+الـ Exposomes عبارة عن مجموعة ما تعرض له أي إنسان
+
+413
+00:41:16,980 --> 00:41:26,660
+يعني الأمر مربوط في التقنيات المخدرية لإمكانية
+
+414
+00:41:26,660 --> 00:41:33,840
+الفحص على شيء معين يعني زمان كنا إذا بدنا نفحص عن
+
+415
+00:41:33,840 --> 00:41:40,040
+جين معينبدّك تجيب الفحص المخبري عن هذا الشيء محدد
+
+416
+00:41:40,040 --> 00:41:44,880
+تحديدًا فأذكر
+
+417
+00:41:44,880 --> 00:41:50,640
+الـ «إيميل» تبعي بدكم تاخدوه وأعطيت الـ «CR»
+
+418
+00:41:50,640 --> 00:41:55,580
+والدكاترة اللي معاكم تليفوناتي إذا حد بحب يتواصل
+
+419
+00:41:55,580 --> 00:42:02,460
+فيه الـ «إيميل» الـ «واتس آب» أنا حاطر فالـ
+
+420
+00:42:03,920 --> 00:42:08,960
+الـ Gene هو شغل واحدة الـ Microbe الفلاني شغل
+
+421
+00:42:08,960 --> 00:42:16,020
+واحدة وجود مثلًا دوة معينة، غذاء معين، مادة معينة
+
+422
+00:42:16,020 --> 00:42:24,220
+في البيئة هاي يعني شغل واحدة فلما أنا آجي أدرس
+
+423
+00:42:24,220 --> 00:42:28,840
+مجموع الـ Genes كلها هيك بضرب واحدة على جهاز أشوف
+
+424
+00:42:28,840 --> 00:42:34,400
+الـ 20 ألفجين مع بعض بسميه إن أنا درست الـ Genome
+
+425
+00:42:34,400 --> 00:42:40,880
+الـ Microbiome برضه بطريقة واحدة فأس واحد بدرس
+
+426
+00:42:40,880 --> 00:42:46,040
+مجمل أنواع البكتيريا بتعرفوا أي مكان في جسم
+
+427
+00:42:46,040 --> 00:42:54,940
+الإنسان الجرافيم الضارة هي الأكثر حوالي 4، 5% 90%،
+
+428
+00:42:54,940 --> 00:43:00,680
+95%، 99% عبارة عن جرافيم مفيدةبس حتى الجيرانفينيوم
+
+429
+00:43:00,680 --> 00:43:07,040
+المفيدة هذه اللي ساكنة علينا ودوانا في كده الآن في
+
+430
+00:43:07,040 --> 00:43:12,440
+وسائل دراسية لدراسة مجملها كلها مرة واحدة، طجة
+
+431
+00:43:12,440 --> 00:43:16,620
+واحدة، تدرسهم كلهم، هذا بيسموها Microbiome فالآن
+
+432
+00:43:16,620 --> 00:43:22,300
+الـ Exposomes عبارة من الـ Exposure يعني اللي هو
+
+433
+00:43:22,300 --> 00:43:28,640
+ما تم التعرض له، نتكلم يعنيبدل ما بدي أقول فلان
+
+434
+00:43:28,640 --> 00:43:33,260
+أكل بروتين كثير وماكلش تهون كثير وأكل Carbohydrate
+
+435
+00:43:33,260 --> 00:43:38,120
+وسط وكذا الفرق بين مجمل ما يتعرض له الإنسان من
+
+436
+00:43:38,120 --> 00:43:44,260
+سواء المركبات، من أدوية، من أشياء بيئية تؤثر في
+
+437
+00:43:44,260 --> 00:43:48,100
+المرض أحيانًا، هذه بيسموها Exposons وهذه من
+
+438
+00:43:48,100 --> 00:43:53,520
+المفاهيم الحديثة بسبب التقدم التكنولوجي في إمكانية
+
+439
+00:43:53,520 --> 00:43:56,440
+إن أنا أبحث عليها، ماشي؟
+
+440
+00:43:58,970 --> 00:44:05,190
+الآن أظن صارت الساعة عشرة إن شاء الله موعدنا يوم
+
+441
+00:44:05,190 --> 00:44:11,200
+الأربعة راح نبدأ إن شاء الله على الوقتويكون يعني
+
+442
+00:44:11,200 --> 00:44:19,100
+الأمور أصبت إن شاء الله بفضل الدكتور … أنا بعتبر
+
+443
+00:44:19,100 --> 00:44:22,960
+الدكتور أحمد و الـ «Class Representative» الـ
+
+444
+00:44:22,960 --> 00:44:30,740
+«سيشن» تبعت الـ الـ الـ «سيشن» هذه، احنا آه كويسة،
+
+445
+00:44:30,740 --> 00:44:35,790
+راح نضلنا نتقابل وإن شاء الله موجودين يعنياللي
+
+446
+00:44:35,790 --> 00:44:41,130
+بحبه أنه الآن خلصنا الفصل الأول في الكتاب وديت
+
+447
+00:44:41,130 --> 00:44:46,250
+الـsoft copy التبعته تطلعوا عليها اقرؤوا إذا حدا
+
+448
+00:44:46,250 --> 00:44:50,790
+في أول جزء المحاضرة القادمة راح نتكلم إن شاء الله
+
+449
+00:44:50,790 --> 00:44:55,570
+عن إذا في حد عنده أي أسئلة
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/Tl5zcdiL4_o.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/Tl5zcdiL4_o.srt
new file mode 100644
index 0000000000000000000000000000000000000000..78d78a149045a268bbc6de479b5472007d80c892
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/Tl5zcdiL4_o.srt
@@ -0,0 +1,2701 @@
+1
+00:00:00,000 --> 00:00:08,880
+تعني بعيدها تقترح عليهم الآن أنا شايف ردود ماشية
+
+2
+00:00:08,880 --> 00:00:19,140
+الأسئلة
+
+3
+00:00:19,140 --> 00:00:26,680
+حول ترتيب الأمور بالنسبة للامتحان وشو أدرس وشو ما
+
+4
+00:00:26,680 --> 00:00:35,310
+أدرس. أجلوها. اللي اتكلمنا كثيرًا عن مواضيع إنه أنت
+
+5
+00:00:35,310 --> 00:00:39,930
+هدفك يعني خلّي عينك على صحيح أنت أحسن مشغول في العلامات
+
+6
+00:00:39,930 --> 00:00:44,570
+و بتسأل و بدك أحسن علامة و تنافس شديد و كل العالم
+
+7
+00:00:44,570 --> 00:00:50,710
+هيك حتى في جامعتنا و لا في أي مكان، بس بالأخير يعني
+
+8
+00:00:50,710 --> 00:00:56,060
+الأهم إنك أنت تطلع فاهم، إنك تطلع مستوعب للكلام
+
+9
+00:00:56,060 --> 00:01:03,000
+بحيث إنك تستطيع إنك يعني تتعامل في الحياة بعدين مع
+
+10
+00:01:03,000 --> 00:01:07,000
+هذه المعلومات. فخلّينا من هذا، مطوع، أنا بسأل إذا حد
+
+11
+00:01:07,000 --> 00:01:14,300
+عنده أسئلة عن المادة العلمية. مش داخل، مش داخل،
+
+12
+00:01:14,300 --> 00:01:19,680
+مطلوب، مش مطلوب، على قدر طموحك، بدك تتعب حالك، بدك
+
+13
+00:01:19,680 --> 00:01:25,520
+ترتاح. إيش اسمه؟  ريح حالك، مافي مشكلة. فنرجع مرة
+
+14
+00:01:25,520 --> 00:01:30,680
+ثانية، الآن بتسألت أنا إيش تركيب البروتين، فكذا
+
+15
+00:01:30,680 --> 00:01:37,100
+واحد حكالي، كتبت، بقرا اسمه Primary، وفيه ناس كتبوا
+
+16
+00:01:37,100 --> 00:01:43,860
+Amino Acids، وفيه ناس كتبوا Secondary و Tertiary. مش
+
+17
+00:01:43,860 --> 00:01:51,090
+حاطين يعني تفاصيل لهذا الأمر. أنا أتمنى بس إنه الـ…
+
+18
+00:01:51,090 --> 00:01:58,910
+الـ… الـ… الـ… الـ«زوم»، الـ«تشات»، الـ«جروب تشات»
+
+19
+00:01:58,910 --> 00:02:03,670
+ولا الـ«هاي»، أنا بتبينش وإنه الـ«دسكتوب» تبعي كله
+
+20
+00:02:03,670 --> 00:02:09,590
+ظاهر عندكم في الصورة. النقطة الأساسية إنه
+
+21
+00:02:09,590 --> 00:02:14,750
+الـ«بروتين» لما نشوفه في الحياة وفي الجسم بيقولوله
+
+22
+00:02:14,750 --> 00:02:19,410
+فيه أربع تركيبات، أربع مستويات من التركيب، من
+
+23
+00:02:19,410 --> 00:02:26,190
+التعقيد. الـ Primary Structure للبروتين هو عبارة عن
+
+24
+00:02:26,190 --> 00:02:31,550
+ترتيب الـ Amino Acids اللي بتشكل منها الـ
+
+25
+00:02:31,550 --> 00:02:37,070
+Polypeptide Chain اللي بتتشكل منها البروتين. فلمّا
+
+26
+00:02:37,070 --> 00:02:42,470
+نتكلم إنه البروتين، يعني هندخل بعد شوية بالتفاصيل
+
+27
+00:02:42,980 --> 00:02:47,140
+بدّي الواحد يتخيله عشان يعرف يفهم أهمية الـ DNA
+
+28
+00:02:47,140 --> 00:02:54,040
+وليش ربنا حطوا فينا بهذه الطريقة. فعنا بقول أربع
+
+29
+00:02:54,040 --> 00:03:03,160
+تركيبات لـ الـ. اللي بده يرفع إيده الدكتور أحمد
+
+30
+00:03:03,160 --> 00:03:06,720
+معانا هو اللي بيخلي. أنا بحب إنه حد يتكلم، بديش الـ
+
+31
+00:03:06,720 --> 00:03:11,560
+Chat هذا. بدي إنه حد يتكلم حتى نفهم، يعني نشرح
+
+32
+00:03:11,560 --> 00:03:17,630
+الموضوع. فلما نتكلم على تركيب الـ Protein نتكلم على
+
+33
+00:03:17,630 --> 00:03:24,030
+أربع خواص فيه أو أربع مستويات من التراكيب فيه. لما
+
+34
+00:03:24,030 --> 00:03:28,070
+نقول بدا نصف الـ Primary Structure لأي Protein
+
+35
+00:03:28,070 --> 00:03:34,010
+بنقول إنه لازم نصف شو هو ترتيب الـ Amino Acids
+
+36
+00:03:34,010 --> 00:03:40,530
+اللي موجودة في الـ Polypeptide Chain. فترتيب الـ
+
+37
+00:03:40,530 --> 00:03:44,330
+Amino Acids هذا هو اللي يعتبر الـ Primary Structure
+
+38
+00:03:44,330 --> 00:03:51,750
+للـ Protein. فإنها حوالي 20، 21 Amino Acid. فبالتالي
+
+39
+00:03:51,750 --> 00:03:58,350
+لما نعد بواحد، اثنين، ثلاثة في الـ Polypeptide
+
+40
+00:03:58,350 --> 00:04:03,870
+Chain. وبنقول إنه في أول أمينو أسد مثلًا «تريبتوفان»
+
+41
+00:04:03,870 --> 00:04:09,790
+«ألانين» مثلًا «أسبارتيت» كذا كذا الأمينو أسد اللي
+
+42
+00:04:09,790 --> 00:04:15,670
+بتعرفوها. هدولة وصف الـ Primary Structure هو وصف
+
+43
+00:04:15,670 --> 00:04:20,110
+لإيش هي الأمينو أسد اللي بتكون منها البروتين. الـ
+
+44
+00:04:20,110 --> 00:04:26,170
+Secondary Structure هو عبارة عن تركيب البروتين
+
+45
+00:04:26,170 --> 00:04:34,380
+الناتج عن العلاقات والتفاعلات والتجاذبات بين الـ
+
+46
+00:04:34,380 --> 00:04:39,520
+Amino Acids جنب بعض. فبينتج عن هذا التجاذب أنه فينا
+
+47
+00:04:39,520 --> 00:04:43,760
+نوعين من الـ Structures اللي بتكون المستوى الثاني
+
+48
+00:04:43,760 --> 00:04:48,000
+في تعقيد البروتين اللي هي بيسموه الـ Alpha Helix
+
+49
+00:04:48,000 --> 00:04:53,180
+أو الـ Beta Pleated Sheets. يعني يا إما نتيجة
+
+50
+00:04:53,180 --> 00:04:58,070
+علاقات الـ Side Chains تبعات الـ Amino Acids تبعات
+
+51
+00:04:58,070 --> 00:05:02,890
+الـ Primary Structure. بيصير البروتين يلف على بعضه
+
+52
+00:05:02,890 --> 00:05:08,690
+إذا بتتخيلوا و بتشوفوا عندكم مثلًا نفترض سلك
+
+53
+00:05:08,690 --> 00:05:13,730
+تليفون بين السماعة وجهاز التليفون، بلولو بيصير
+
+54
+00:05:13,730 --> 00:05:19,610
+البروتين يتلولو بهذه الطريقة. فوجود اللي بيسمونه
+
+55
+00:05:19,610 --> 00:05:24,170
+Alpha Helix أو Beta Pleated Sheets. هدولة أنواع
+
+56
+00:05:24,500 --> 00:05:29,880
+أشكال التركيب الثانوي للبروتين. يكون نتيجة علاقات
+
+57
+00:05:29,880 --> 00:05:33,420
+الـ Amino Acids مع بعض. وبتكون الـ Amino Acids
+
+58
+00:05:33,420 --> 00:05:37,400
+هدولة جنب بعض، لأنه حتى يلف، هذا الشكل القريب يكون
+
+59
+00:05:37,400 --> 00:05:42,680
+علاقات بين الـ Amino Acids مع بعض. لما نكون نتكلم
+
+60
+00:05:42,680 --> 00:05:46,140
+عن الـ Tertiary Structure للبروتين، زي الـ Globular
+
+61
+00:05:46,140 --> 00:05:53,130
+Structure. إنه يكون على شكل مثلًا، أبارع، ثلاث أحبال
+
+62
+00:05:53,130 --> 00:05:59,030
+هيك، ملف على بعض، أو على شكل كروي أو كده، بيكون صار إنه
+
+63
+00:05:59,030 --> 00:06:06,750
+interaction between amino acid units on faraway
+
+64
+00:06:06,750 --> 00:06:13,090
+points on the amino acid polypeptide chain. يعني
+
+65
+00:06:13,090 --> 00:06:18,250
+حتى يلف بهذا الشكل، اللي يصير شكل كروي أو شكل بشكل
+
+66
+00:06:18,250 --> 00:06:20,530
+آخر، ويكون نتيجة
+
+67
+00:06:23,460 --> 00:06:29,180
+التفاعلات بين الـ Amino Acids بعيدة عن بعضها في
+
+68
+00:06:29,180 --> 00:06:34,880
+الـ Primary Structure. فهذه بتكون الـ Tertiary
+
+69
+00:06:34,880 --> 00:06:40,980
+Structure لأي بروتين. ولمّا بعدين نتكلم على أن مثلًا
+
+70
+00:06:40,980 --> 00:06:46,500
+الـ Hemoglobin بروتين عبارة عن حقيقة أربع
+
+71
+00:06:46,500 --> 00:06:52,950
+Polypeptides، أربع قطع، Two Alphas و Two Betas. كل
+
+72
+00:06:52,950 --> 00:06:56,910
+واحد منهم Alpha أو Beta هي عبارة عن بوليببتيد بتاع
+
+73
+00:06:56,910 --> 00:07:03,190
+الـ Chain واحد معين. وفي نصه فيه Hemomolecule، الـ
+
+74
+00:07:03,190 --> 00:07:06,370
+Hemomolecule اللي فيه الحديد اللي بيمسك الـ Oxygen
+
+75
+00:07:06,370 --> 00:07:11,110
+فلما نتكلم على الـ Structure تبع الـ Total
+
+76
+00:07:11,110 --> 00:07:19,760
+Hemoglobin Protein بنقول إنه عبارة عن Four. وكل
+
+77
+00:07:19,760 --> 00:07:24,640
+واحدة منها Globular «هيمو» و «جلوبين» «جلوبين»
+
+78
+00:07:24,640 --> 00:07:30,500
+يعني كروي. فالـ «هيمو» و «جلوبين» في أربع
+
+79
+00:07:30,500 --> 00:07:36,720
+Polypeptide Chains، Two Alphas و Two Betas. فالآن
+
+80
+00:07:36,720 --> 00:07:43,840
+يعني هذا كبروتين موجود في الجسم، بتكون السر الأول
+
+81
+00:07:43,840 --> 00:07:47,570
+فيه في الـ Primary Structure، اللي هو الـ Amino
+
+82
+00:07:47,570 --> 00:07:56,130
+Acids اللي بتكون منها. وبعد ذلك، بتعقد الموضوع بالـ
+
+83
+00:07:56,130 --> 00:07:59,650
+Secondary Structure، نتيجة الـ Alpha Helices والـ
+
+84
+00:07:59,650 --> 00:08:04,370
+Beta Pleated Sheets. وبعدين بيصير أنها Tertiary
+
+85
+00:08:04,370 --> 00:08:10,070
+Structure نتيجة الحلقات
+
+86
+00:08:10,070 --> 00:08:15,480
+بين الـ Amino Acids البعيدة عن بعض. وبعدين ندخل في الـ
+
+87
+00:08:15,480 --> 00:08:19,360
+Total Structure بالـ Quaternal Structure، التركيب
+
+88
+00:08:19,360 --> 00:08:24,560
+الرباعي، الرابعي للبروتين. فأي بروتين لما نيجي نصفه
+
+89
+00:08:24,560 --> 00:08:30,220
+نتكلم على أربع مستويات من الـ Structure. فهو ياما
+
+90
+00:08:30,220 --> 00:08:35,960
+Primary، و Secondary، و Tertiary، و Quaternary. الأمور
+
+91
+00:08:35,960 --> 00:08:38,340
+هيك واضحة، في حد عنده سؤال؟
+
+92
+00:08:41,490 --> 00:08:46,890
+دكتور أحمد، ماشي الحال، الشباب في حد .. ما .. ما
+
+93
+00:08:46,890 --> 00:08:51,050
+دكتور، مافي .. مافي .. مافي. تحكي فيه جمانة رفعت
+
+94
+00:08:51,050 --> 00:08:56,350
+إيدها، تمام، بتخلي الجمانة تتكلم، أو على أقل يعني
+
+95
+00:08:56,350 --> 00:09:02,190
+اثنين، ثلاثة، تعطيهم سماح يتكلموا عشان نسمع يعني
+
+96
+00:09:02,190 --> 00:09:06,310
+يكونوا تفاعلوا بسرعة وشو اسمها؟ إن شاء الله، هنخلي
+
+97
+00:09:06,310 --> 00:09:13,390
+الدكتورة جمانة. المستوى الرابع هو علاقات، إنه أكثر من
+
+98
+00:09:13,390 --> 00:09:19,670
+قطعة تدخل في تركيبه يعني، بدك تعتبر إنه زي «ليجو»…
+
+99
+00:09:19,670 --> 00:09:24,990
+ثواني، جمانة، بس بعد إذنك، دكتور، تفضل، كمل كأنه
+
+100
+00:09:24,990 --> 00:09:28,790
+زي قطعة «ليجو»، تعرفوها لعبة الأطفال اللي بتكون
+
+101
+00:09:28,790 --> 00:09:34,350
+أكثر من قطعة. أحيانًا يكون أربع أو خمس أو أقل،
+
+102
+00:09:34,350 --> 00:09:41,430
+اثنين، ثلاثة، individual Polypeptide chains. يعني
+
+103
+00:09:41,430 --> 00:09:47,050
+عبارة عن ثلاثة أو أربع قطع بروتينية بيشتركوا مع
+
+104
+00:09:47,050 --> 00:09:51,230
+بعض، بيعطينا البروتين الأخير. فزي الـ Hemoglobin، الـ
+
+105
+00:09:51,230 --> 00:09:55,930
+Hemoglobin حقيقة هي أربع Polypeptide chains، أربع
+
+106
+00:09:55,930 --> 00:10:01,310
+Globins، اثنين ألفا واثنين بيتا. كل واحد فيهم فيها
+
+107
+00:10:01,310 --> 00:10:05,710
+شغلة Hemoglobin، راح ندخلها يعني Hem Group، اللي هي
+
+108
+00:10:05,710 --> 00:10:16,710
+تمسك الـ Oxygen. ف… ماشي أخت سهام. آه، الآن اللي سألت
+
+109
+00:10:16,710 --> 00:10:24,910
+سؤال، رفعت إيدها تتكلم، جمانة.
+
+110
+00:10:24,910 --> 00:10:32,690
+أتكلم. آه طيب الآن. فالسر في كل التفاعلات البروتين
+
+111
+00:10:32,690 --> 00:10:39,540
+وخواص المادة الحية هي حقيقةً في ترتيب الـ
+
+112
+00:10:39,540 --> 00:10:46,700
+Amino Acids اللي موجودة في البروتين. ماشي، وحقيقة
+
+113
+00:10:46,700 --> 00:10:52,800
+يعني الواحد، أنا بقول بده يعتبر هيك البروتين عبارة
+
+114
+00:10:52,800 --> 00:10:59,020
+عن، إذا بدكم هيك عشان الواحد يستوعبها، بقول يعتبر
+
+115
+00:10:59,020 --> 00:11:06,490
+إنها زي باللغة العربية، نقول قصيدة البردة، مدح
+
+116
+00:11:06,490 --> 00:11:12,690
+الرسول، قصيدة المعلقات، قصيدة عبارة عن مثلًا 150
+
+117
+00:11:12,690 --> 00:11:17,890
+بيت، بس بالأخير تركيب القصيدة في اللغة العربية
+
+118
+00:11:17,890 --> 00:11:23,830
+بالأخير هي أحرف، صحيح بتتكون من كلمات، بس الكلمات
+
+119
+00:11:23,830 --> 00:11:28,750
+بترجع بالأخير للأحرف، وعنا في اللغة العربية 28 حرف،
+
+120
+00:11:30,460 --> 00:11:35,800
+البروتين لما نشوفه في واقع الحياة هو بيكون مثلًا
+
+121
+00:11:35,800 --> 00:11:43,680
+نعتبر قصيدة متكونة من كلمات، نتيجة مكونة من أحرف
+
+122
+00:11:43,680 --> 00:11:50,460
+فبالأخير السر في القصيدة هي في ترتيب الأحرف تبعها
+
+123
+00:11:50,460 --> 00:12:02,330
+فالآن الـ DNA هو تمثيل مشفر بطريقة معينة حتى يضمن
+
+124
+00:12:02,330 --> 00:12:07,410
+كمادة وراثية للمعلومات اللي بالأخير بتعطينا الـ
+
+125
+00:12:07,410 --> 00:12:12,770
+Protein وبتعطينا القصيدة. فهناك تشفير معين، رموز،
+
+126
+00:12:12,770 --> 00:12:19,930
+ترميز لكل حرف، إنه شو اللي بيقابله من الـ DNA حتى
+
+127
+00:12:19,930 --> 00:12:23,470
+يمكن عملية إنه نعمل
+
+128
+00:12:25,980 --> 00:12:32,820
+نعمل الـ «بروتينات» اللي احنا بحاجتها. فالآن
+
+129
+00:12:32,820 --> 00:12:38,780
+لما ندرس المادة الوراثية اللي موجودة في الإنسان
+
+130
+00:12:38,780 --> 00:12:44,360
+وبتكون في كل خلايا الإنسان، الإنسان الواحد بشكل
+
+131
+00:12:44,360 --> 00:12:49,740
+رئيسي، بشكل يعني فيه هناك كأنه أكثر من نوع مادة
+
+132
+00:12:49,740 --> 00:12:53,340
+وراثية في جسم الواحد، راح نحكي عن نوعين زي هيك، بس
+
+133
+00:12:53,340 --> 00:12:56,640
+بشكل أساسي كل خلايا الإنسان، لأنه بيبدأ من خلية
+
+134
+00:12:56,640 --> 00:13:00,780
+واحدة، بيتم تلقيحها، البويضة الملقحة بالحيوان
+
+135
+00:13:00,780 --> 00:13:05,120
+المنوي من الأب والأم، بالأخير الخلية الواحدة هذه
+
+136
+00:13:05,120 --> 00:13:09,440
+هي اللي بتنقسم كل الانقسامات المطلوبة، وبنتج عنها
+
+137
+00:13:09,440 --> 00:13:14,180
+إنه بيصير عندنا المظهر
+
+138
+00:13:14,180 --> 00:13:19,200
+اللي بنشوفه كذكر أو أنثى أو طفل أو كبير أو كده،
+
+139
+00:13:19,200 --> 00:13:27,930
+المادة الوراثية في الإنسان تقريبًا 97% موجودة في
+
+140
+00:13:27,930 --> 00:13:38,090
+النواة داخل الخلية. فـ 97% من المادة الوراثية موجودة
+
+141
+00:13:38,090 --> 00:13:43,690
+في الـ Nuclear Chromosomes. وهي حطيت لكم صورة رسمية
+
+142
+00:13:43,690 --> 00:13:48,490
+أو صورة مش رسمية، يعني صورة الفحص اللي هو الـ
+
+143
+00:13:48,490 --> 00:13:52,530
+Karyotype اللي بنعمله. وبكون في حالة الـ Cell
+
+144
+00:13:52,530 --> 00:13:56,910
+Division، ممكن يكونوا مقابلين بعضه، بكون لهم ترتيب
+
+145
+00:13:56,910 --> 00:14:04,620
+معين، وبنشوفه. هذا اللي هو بدرجة أساسية المادة
+
+146
+00:14:04,620 --> 00:14:09,040
+الوراثية تبع الإنسان في كل خلية، حوالي 97%، يعني
+
+147
+00:14:09,040 --> 00:14:18,080
+تقريبًا 100%. وبتكون لأنها لهم 23 زوج من
+
+148
+00:14:18,080 --> 00:14:22,460
+الـ Chromosomes. فرح نقدر بعدين بتفصيل أكثر،
+
+149
+00:14:22,460 --> 00:14:30,970
+الـ Chromosomes هذه، 22 زوج عبارة عن كروموزومات
+
+150
+00:14:30,970 --> 00:14:39,510
+أوتوزومال، يعني جسمية، اللي هي من 1 إلى 22، عبارة عن
+
+151
+00:14:39,510 --> 00:14:46,170
+تجميع للـ DNA بشكل معين. وزوج آخر من الـ Sex
+
+152
+00:14:46,170 --> 00:14:50,290
+chromosomes، اللي هما الـ X والـ Y. فهي اللي هي
+
+153
+00:14:50,290 --> 00:14:57,320
+التركيب تبع الـ Nuclear Chromosomes. نسميهم المادة
+
+154
+00:14:57,320 --> 00:15:02,200
+الوراثية في النواة، وتكون على شكل كروموزومات. راح
+
+155
+00:15:02,200 --> 00:15:06,420
+ناخد تفصيلها وتركيبها وعلاقاتها بشكل أدق بعد شوية.
+
+156
+00:15:06,420 --> 00:15:10,760
+تقريبًا مية بالمية، طبعًا هدول الـ Nuclear Chromosomes
+
+157
+00:15:10,760 --> 00:15:14,680
+نصهم من الأب ونصهم من الأم. الـ Mitochondrial
+
+158
+00:15:14,680 --> 00:15:20,220
+chromosomes، بنسميهم قطعة صغيرة، تمثل حوالي 3% من
+
+159
+00:15:20,220 --> 00:15:26,020
+الـ DNA في الخلايا الجسمانية، بتكون من خلال الـ
+
+160
+00:15:26,020 --> 00:15:30,580
+mitochondria. يعني الـ mitochondria اللي هي بتعرفوا
+
+161
+00:15:30,580 --> 00:15:34,640
+كلكم من المدارس، إنها بنسميها أفران الطاقة في
+
+162
+00:15:34,640 --> 00:15:40,600
+الخلية. بتكون هي المحل اللي بتتم فيها الـ Glycolysis
+
+163
+00:15:40,600 --> 00:15:46,940
+والـ Respiratory Chain والـ Krebs Cycle. بحيث إنه يتم
+
+164
+00:15:46,940 --> 00:15:51,940
+هضم المواد زي الـ Glucose، بحيث يعطينا بالأخير ATP
+
+165
+00:15:51,940 --> 00:15:58,820
+وطاقة، وبتكون الخلية بتتحرك من خلال الـ ATP اللي
+
+166
+00:15:58,820 --> 00:16:03,230
+بتحتاجه في عملية الطاقة. فالـ Mitochondrial
+
+167
+00:16:03,230 --> 00:16:10,750
+chromosomes تمثل 3% من الـ DNA. لاحظنا إن الـ
+
+168
+00:16:10,750 --> 00:16:15,370
+Proteins اللي هذا الـ DNA اللي موجود في الـ
+
+169
+00:16:15,370 --> 00:16:21,710
+Mitochondria مرتبط بالبروتينات اللي احنا بحاجتها
+
+170
+00:16:21,710 --> 00:16:27,570
+عشان نسوي الـ ATP، عشان في الـ steps، عشان نكون
+
+171
+00:16:27,570 --> 00:16:32,000
+مركبات الطاقة الـ ATP. كل الأشياء اللي أنا عادة
+
+172
+00:16:32,000 -->
+
+223
+00:21:26,130 --> 00:21:30,770
+بيعتبروا أنه في شيء جوا الشيء في الـ Mitochondria
+
+224
+00:21:30,770 --> 00:21:40,750
+جواها في DNA والبروتينات اللي بتنتج عن تشغيل وتفعيل
+
+225
+00:21:40,750 --> 00:21:46,110
+الـ DNA بحيث يعطينا بروتين هو راح يكون إنه
+
+226
+00:21:46,110 --> 00:21:50,970
+يعطينا البروتينات اللازمة لعملية إنتاج الطاقة
+
+227
+00:21:50,970 --> 00:21:55,030
+وإنتاج الـ DNA، ما هي وظيفة الميتوكندرية؟
+
+228
+00:21:55,030 --> 00:22:01,070
+إنها تطلع الـ ATP اللي  بتشغل التفاعلات الكيموية والحركة
+
+229
+00:22:01,070 --> 00:22:07,020
+في الخلية وغيرها، بدها طاقة، فبتكون من الـ ATP
+
+230
+00:22:07,020 --> 00:22:11,280
+اللي بنتج من الميتوكندرية نتيجة تفاعلات تحتاج
+
+231
+00:22:11,280 --> 00:22:15,700
+إلى بروتينات، والـ DNA لهذه البروتينات في الميتوكندرية
+
+232
+00:22:15,700 --> 00:22:21,800
+وهذا يتم نقله من خلال البويضة فقط، يعني الـ sperm
+
+233
+00:22:21,800 --> 00:22:26,420
+من الأب ما له دخلة، عشان هيك لما تدرس الـ
+
+234
+00:22:26,420 --> 00:22:29,180
+mitochondrial inheritance والـ mitochondrial
+
+235
+00:22:29,180 --> 00:22:36,450
+diseases بتكون انتقالها عن طريق الأم، واضح؟ في لسة
+
+236
+00:22:36,450 --> 00:22:40,790
+سؤال، اسألني أنت يا أحمد إذا في حد عنده شيء مش
+
+237
+00:22:40,790 --> 00:22:45,470
+واضح، آه
+
+238
+00:22:45,470 --> 00:22:49,730
+فيه بيعلق يعني، بيسأل، بيعقب على السؤال، بيقول
+
+239
+00:22:49,730 --> 00:22:55,530
+يعني كل الموضوع إنه العمليات بتحتاج ATP، طبعاً كل
+
+240
+00:22:55,530 --> 00:23:00,870
+كثير من العمليات الكيميائية والحركية وغيرها، فالخلايا
+
+241
+00:23:00,870 --> 00:23:06,060
+بدها طاقة، الطاقة بتيجي من الـ ATP، الـ ATP بنتجه
+
+242
+00:23:06,060 --> 00:23:11,840
+بتفاعلات كيميائية بدها أنزيمات وبروتينات، نتيجة يعني
+
+243
+00:23:11,840 --> 00:23:16,780
+بتكون في الـ mitochondria، وهدول الـ DNA
+
+244
+00:23:16,780 --> 00:23:21,700
+المسؤول عنها موجود جوا الـ mitochondria، بيمثل 3%
+
+245
+00:23:21,700 --> 00:23:27,680
+من الـ DNA تبع الخلية، وهذا يتم نقله من خلال الأم
+
+246
+00:23:27,680 --> 00:23:34,000
+فقط، الأب ما إله دخلة، فهمتوا علي كيف؟ وهذه حتى إذا
+
+247
+00:23:34,000 --> 00:23:38,640
+واحد قرأ دراسة قبل مدة، إنه بيرجعوا البشر كلهم لـ 7
+
+248
+00:23:38,640 --> 00:23:44,740
+أمهات، لأنه فيه variation بشكل معين، وإنه بتكون
+
+249
+00:23:44,740 --> 00:23:48,540
+لدراسة الـ Mitochondrial DNA والـ Mitochondrial
+
+250
+00:23:48,540 --> 00:23:52,940
+Chromosomes، فهدول موجودين، وهدول أحيانًا بسببوا
+
+251
+00:23:52,940 --> 00:23:58,100
+أمراض حتى لو ما كان في الـ Nucleus اللي هي الجزء
+
+252
+00:23:58,100 --> 00:24:03,100
+الأكبر من الـ DNA فيها، بس دائماً لما نقول gene هو
+
+253
+00:24:03,100 --> 00:24:09,040
+شيء بالمادة الوراثية يعني يمكن توريثه، ويمكن اللي
+
+254
+00:24:09,040 --> 00:24:14,280
+أخدناه  في عملية الانقسام، وبالتالي بتعطينا بدل نسخة
+
+255
+00:24:14,280 --> 00:24:20,940
+واحدة، نسختين، ويتكاثر بشكل يحفظ المادة الوراثية
+
+256
+00:24:20,940 --> 00:24:24,940
+اللي بتعطينا شكل الـ protein اللي راح يطلع بالأخير،
+
+257
+00:24:24,940 --> 00:24:26,900
+واضح؟
+
+258
+00:24:32,000 --> 00:24:37,120
+في حد عنده سؤال؟
+
+259
+00:24:37,120 --> 00:24:43,260
+طيب، التركيب،
+
+260
+00:24:43,260 --> 00:24:50,860
+خلّينا نرجع لهذه شوية، تركيب الـ DNA، وهذا في سنة
+
+261
+00:24:50,860 --> 00:24:56,240
+الـ 1954، وبعدين أخذوا عليه جائزة نوبل، عالمين
+
+262
+00:24:56,240 --> 00:25:02,130
+اسمهما Watson و Crick، أثبتوا أو من خلال دراستهما
+
+263
+00:25:02,130 --> 00:25:07,990
+باستخدام تقنية الـ X-Ray Crystallography،  أي طريقة بندرس
+
+264
+00:25:07,990 --> 00:25:15,650
+فيها المركبات وتركيبها الكيميائي، أنه بنشع عليها X
+
+265
+00:25:15,650 --> 00:25:21,210
+-Rays وبنشوف في الفيلم كيف تركيبه، وكذا أثبتوا أن
+
+266
+00:25:21,210 --> 00:25:28,080
+الـ DNA عبارة عن سلم حلزوني، بهذا الشكل، السلم العادي
+
+267
+00:25:28,080 --> 00:25:34,840
+بتلاقي يعني قصتين طوال وبينهم أقصار، الـ steps
+
+268
+00:25:34,840 --> 00:25:41,620
+اللي بتطلع عليهم، فبالنسبة للـ DNA السلم هذا
+
+269
+00:25:41,620 --> 00:25:47,820
+لولبي، يعني بيقعد يلف على بعضه، فإذا أنت بتشوفه
+
+270
+00:25:47,820 --> 00:25:54,380
+تركيبه، يعني هذا هو شكله، اللي هو بنسميه سلم لولبي
+
+271
+00:25:54,380 --> 00:26:01,780
+بالـ Double Helix Ladder، يعني هذا شكله، الدورة
+
+272
+00:26:01,780 --> 00:26:07,100
+الكاملة منه، زي هذا الشكل، 34 Angstrom
+
+273
+00:26:07,100 --> 00:26:14,480
+اللي هو كـ Size، وبين عشر خطوات
+
+274
+00:26:14,480 --> 00:26:20,640
+أو عشر، المكان اللي بتحط إجرك عليه في السلم، العتبات
+
+275
+00:26:20,640 --> 00:26:25,120
+تبعته، اللي هي طولها بين 1 و 3.4 من عشرة أنجستروم، لما تيجي تاخد تركيب هذا
+
+276
+00:26:25,120 --> 00:26:28,700
+الأمر، بتلاقي أول شيء أنه في اللي هي الخضرة الفاتحة
+
+277
+00:26:28,700 --> 00:26:35,120
+هذه اللي هو الريبوز، الريبوز، اللي هو
+
+278
+00:26:35,120 --> 00:26:43,990
+السكر الخماسي، اللي هو هذا الريبوز، آسف، بالـ DNA
+
+279
+00:26:43,990 --> 00:26:50,850
+ديوكسي ريبوز، لأن الـ RNA هو اللي فيه الريبوز بس،
+
+280
+00:26:50,850 --> 00:26:55,870
+الريبوز هو سكر خماسي،
+
+281
+00:26:55,870 --> 00:27:01,130
+يعني فيه خمس ذرات كربون، وفيه من طرف ثاني فوسفات،
+
+282
+00:27:01,130 --> 00:27:06,010
+يعني فيه خمس ذرات كربون، ومن طرف ثاني فوسفات،
+
+283
+00:27:09,390 --> 00:27:15,730
+الخشب الطويلة تبعت السلم عبارة عن هيك: فوسفات ديوكسي
+
+284
+00:27:15,730 --> 00:27:19,090
+ريبوز، فوسفات ديوكسي ريبوز، فوسفات ديوكسي ريبوز،
+
+285
+00:27:19,090 --> 00:27:28,310
+بالترتيب هذا، هذا شيء ثابت، ماشي، بالنص بينهم فيه
+
+286
+00:27:28,310 --> 00:27:34,100
+قواعد نيتروجينية، nitrogen bases، فيه عندنا الـ…
+
+287
+00:27:34,100 --> 00:27:40,860
+الـ… يعني هنا هذا التركيب الـ… الـ…  أقولها، هذه
+
+288
+00:27:40,860 --> 00:27:46,020
+مجموعة الفوسفات، وهذه الـ Ribose، وهنا بتشبك فيه
+
+289
+00:27:46,020 --> 00:27:50,280
+الـ Base رقم واحد، بعدين بيجي فوسفات، بيجي Ribose،
+
+290
+00:27:50,280 --> 00:27:54,160
+بيجي الـ Base رقم اثنين، فوسفات، Ribose، الـ Base رقم
+
+291
+00:27:54,160 --> 00:28:01,830
+ثلاثة، بتيجي بهذا الترتيب الـ… بالنسبة لـ… لما ناخد،
+
+292
+00:28:01,830 --> 00:28:10,810
+نركز على تركيبة الريبوز، إنه إذا بتاخدوا
+
+293
+00:28:10,810 --> 00:28:17,310
+في الكيمياء الحيوية، بتكون إنك أنت بتقدر ترسم شكل الريبوز
+
+294
+00:28:17,310 --> 00:28:26,690
+هذا، جاي خماسي، بس بنحسب بما أنه هنا الأكسجينة الـ
+
+295
+00:28:26,690 --> 00:28:31,870
+Deoxyribose، بيكون الريبوز فيه أكتر من هيك، بس
+
+296
+00:28:31,870 --> 00:28:37,730
+الأكسجينة بنحسب عليها، فبتقدروا أن هذا الكربون
+
+297
+00:28:37,730 --> 00:28:41,210
+الأول، وهذه الكربون الثانية، وهذه الثالثة، وهذه
+
+298
+00:28:41,210 --> 00:28:47,680
+الرابعة، وهذه الخامسة، فالـ Phosphate بتشبك على من جهة
+
+299
+00:28:47,680 --> 00:28:54,020
+في رقم خمسة، ومن جهة في رقم ثلاثة، فلما نيجي نتكلم
+
+300
+00:28:54,020 --> 00:29:02,780
+كيف شكل ترتيب العصايتين، القشريتين بيكونوا عكس بعض،
+
+301
+00:29:02,780 --> 00:29:09,340
+بحيث إنه في عصاية من جهة بتبدأ بالـ riboses، بتشبك
+
+302
+00:29:09,340 --> 00:29:15,820
+عليها من جهة رقم خمسة، بيسموها الـ 5'N، بيظل ماشي لحد
+
+303
+00:29:15,820 --> 00:29:20,140
+الـ 3' (ثري برايم)، إنه بالنسبة للـ Ladder الثاني
+
+304
+00:29:20,140 --> 00:29:24,940
+بيكون ماشي بالعكس، بدأ من تحت بالـ Five وبيطلع من
+
+305
+00:29:24,940 --> 00:29:29,360
+فوق على الـ 3' (ثري برايم) أو على الـ Three Prime، يعني هدول
+
+306
+00:29:29,360 --> 00:29:36,620
+في تفاصيل التركيب الكيميائي للـ DNA، هدول العصايتين
+
+307
+00:29:36,620 --> 00:29:41,960
+أو الخشبتين الطوال، بيلفوا على بعض بهذا الشكل،
+
+308
+00:29:42,540 --> 00:29:51,040
+وبكونوا يعني، بكونوا ماشيين يعني اتجاههم من خمسة
+
+309
+00:29:51,040 --> 00:29:55,540
+لثلاثة، ومن خمسة لثلاثة، حتى يظبط إن يكون هذا الشكل
+
+310
+00:29:55,540 --> 00:30:00,140
+بهذه الطريقة، واللي بمسكهم بالنص اللي هي العتبات
+
+311
+00:30:00,140 --> 00:30:06,730
+اللي بقدر أجر عليها وأنا طالع، بيكون في عندي زوج من
+
+312
+00:30:06,730 --> 00:30:12,470
+الأحماض الأمينية، الـ Nitrogenous Bases، القواعد
+
+313
+00:30:12,470 --> 00:30:17,670
+النيتروجينية، فالقواعد النيتروجينية بنقسمهم لشيء
+
+314
+00:30:17,670 --> 00:30:21,790
+اسمه Purines، قواعد نيتروجينية هي فيها نيتروجين
+
+315
+00:30:21,790 --> 00:30:26,570
+وكربون بهذا الشكل، فالـ Purines اللي هي الأكبر فيها
+
+316
+00:30:26,570 --> 00:30:30,650
+Two Rings، منها الأدينين ومنها الجوانين،
+
+317
+00:30:30,650 --> 00:30:35,650
+وهذا المفروض أخدناه في الـ Biochemistry، فالـ Purines
+
+318
+00:30:35,650 --> 00:30:39,910
+اللي هم الأكبر، والـ Pyrimidines اللي هم الأصغر
+
+319
+00:30:39,910 --> 00:30:45,930
+اللي هم الثايمين والسايتوسين، فالـ DNA بيكون هدول
+
+320
+00:30:45,930 --> 00:30:51,570
+الأربعة  المشتركين، كل step بنحط أجرنا عليها وإحنا
+
+321
+00:30:51,570 --> 00:30:57,510
+طالعين على السلم، بتكون واحد Purine مع واحد
+
+322
+00:30:57,510 --> 00:31:02,490
+Pyrimidine، بس الأدينين مع الثايمين، والجوانين مع الـ
+
+323
+00:31:02,490 --> 00:31:09,380
+سايتوسين، يعني دائماً على الجهة هذه، إحدى واحدة من
+
+324
+00:31:09,380 --> 00:31:12,860
+أربع خيارات ممكن تكون عندي، ممكن تكون Guanine،
+
+325
+00:31:12,860 --> 00:31:18,960
+Cytosine، Adenine، أو Guanine مرة ثانية،
+
+326
+00:31:18,960 --> 00:31:24,240
+فكل واحد من هذا لازم يشبك مع واحد من النوع الثاني،
+
+327
+00:31:24,240 --> 00:31:28,660
+فهنا كانت Guanine  متشبكة مع Cytosine، هنا
+
+328
+00:31:28,660 --> 00:31:34,090
+Cytosine مع Guanine، هنا Adenine مع الثايمين، فهدول
+
+329
+00:31:34,090 --> 00:31:37,070
+الأدينين والثايمين زي ما أنتم شايفين بيكون two
+
+330
+00:31:37,070 --> 00:31:45,180
+bonds، وبين الجوانين والسايتوسين ثلاث bonds، Hydrogen
+
+331
+00:31:45,180 --> 00:31:49,380
+bond، يعني نوع عام ضعيف كثير، مش
+
+332
+00:31:49,380 --> 00:31:53,660
+قوية كثير، يعني مش Covalent bond، مش Ionic bond،
+
+333
+00:31:53,660 --> 00:31:58,460
+يعني شيء قوي كثير، لأ، عبارة عن شيء ممكن أنا أفكه وأ
+
+334
+00:31:58,460 --> 00:32:04,520
+أركبه، بس فيه قوة، وانتظام، وممكن يشبك مع بعض،
+
+335
+00:32:04,520 --> 00:32:12,300
+فبالنسبة لتركيب الـ DNA، هذا تركيبه، بالنسبة
+
+336
+00:32:12,300 --> 00:32:21,740
+لترتيب اللي بيعطينا الشفرة عشان نعرف نطلع البروتين،
+
+337
+00:32:21,740 --> 00:32:28,020
+اللي كويس هو ترتيب هذه الـ Nitrogenous Bases،
+
+338
+00:32:28,020 --> 00:32:32,280
+هذا الترتيب هو اللي بالأخير راح يكون مسؤول عن
+
+339
+00:32:32,280 --> 00:32:38,280
+البروتين اللي راح يطلع، فطبعاً
+
+340
+00:32:38,280 --> 00:32:43,690
+يعني وجود هذا التركيب، سبحان الله، يعني عجيب، ويعني
+
+341
+00:32:43,690 --> 00:32:47,250
+فعلاً اللي اكتشفوه وفسروا الظواهر اللي إحنا
+
+342
+00:32:47,250 --> 00:32:51,950
+بنشوفها، كيف الخلية بتنقسم، كيف ممكن المادة
+
+343
+00:32:51,950 --> 00:32:56,470
+الوراثية تورث، كم ممكن أن يحافظ عليها، كيف يتم
+
+344
+00:32:56,470 --> 00:33:02,570
+نسخها، كيف يتم التعامل معها، أخذوا جائزة نوبل، وهذه
+
+345
+00:33:02,570 --> 00:33:06,030
+يعني بتفسر كثير من الظواهر، وهذا الآن اللي إحنا
+
+346
+00:33:06,030 --> 00:33:10,790
+بنعتبره في علم الوراثة، في حد عنده سؤال؟ في شيء مش
+
+347
+00:33:10,790 --> 00:33:11,230
+واضح؟
+
+348
+00:33:17,730 --> 00:33:23,910
+دكتور أحمد، أو غيره، أو أي حد عنده أي سؤال؟ لا، دكتور
+
+349
+00:33:23,910 --> 00:33:28,030
+اتوكل على الله، غالباً ما في أسئلة في الشاشة، طيب،
+
+350
+00:33:28,030 --> 00:33:34,550
+الآن، دكتور، في سؤال من دكتورة سيهام، تسأل شو اسم
+
+351
+00:33:34,550 --> 00:33:40,630
+الأشعة؟ هذه تقنية أو التقنية في دراسة اللي اشتغل
+
+352
+00:33:40,630 --> 00:33:50,030
+عليها واتسون وكريك، آه آه آه، بحكيلك من الطرق اللي
+
+353
+00:33:50,030 --> 00:33:55,350
+قديمة في دراسة التركيب الكيميائي للمركبات، اللي هي
+
+354
+00:33:55,350 --> 00:34:04,210
+إنك بتخلي المادة على شكل بلورات، شايف علي؟ يعني أنت
+
+355
+00:34:04,210 --> 00:34:13,390
+بتجيب سواء DNA، سكر، بروتين، دهون، أي شيء، بتبردها
+
+356
+00:34:13,390 --> 00:34:19,890
+بحيث تصبح على شكل بلورة، يعني إنها ترتب حالها بشكل
+
+357
+00:34:19,890 --> 00:34:23,190
+منتظم،
+
+358
+00:34:23,190 --> 00:34:28,830
+مش يعني فوضى، فلما ترتبها بشكل منتظم، بعدين
+
+359
+00:34:28,830 --> 00:34:36,250
+بتعرضها لأشعة X، لما نيجي على زي أشعة العظام، لما
+
+360
+00:34:36,250 --> 00:34:41,670
+نتعرضها لهذه الأشعة، تتفرج الجهة الثانية على كيف
+
+361
+00:34:41,670 --> 00:34:47,750
+صورتها من خلال الأشعة على فيلم الأشعة، بتقدر تستنتج
+
+362
+00:34:47,750 --> 00:34:52,010
+كيف كان تركيبها، فهذه التقنية اسمها X-Ray
+
+363
+00:34:52,010 --> 00:34:58,280
+Crystallography، يعني Crystal بلورة، وgraphy يعني
+
+364
+00:34:58,280 --> 00:35:04,240
+شو اسمه؟ عبارة عن تصوير، التصوير البلوري عن طريق
+
+365
+00:35:04,240 --> 00:35:09,880
+أشعة X، هيك اللي كان يستخدموه، فمن خلالها الأبعاد
+
+366
+00:35:09,880 --> 00:35:14,400
+اللي هي بنحكيها الأنجستروم، اللي هي إذا تتفرج
+
+367
+00:35:14,400 --> 00:35:18,940
+هنا إنه 20 أنجستروم، وهي 34 أنجستروم،
+
+368
+00:35:18,940 --> 00:35:24,680
+وبين واحدة وواحدة 3.4، وفي عشرة في كل لولب، هي من
+
+369
+00:35:24,680 --> 00:35:29,570
+خلال طريقة الدراسة هذه، استطعنا نقرأ شو تركيبها،
+
+370
+00:35:29,570 --> 00:35:34,910
+واضحة؟ فهي X-Ray Crystallography، يعني التصوير البلوري
+
+371
+00:35:34,910 --> 00:35:42,730
+بأشعة X، هذه التقنية، وهيك عرفوا تركيب الـ DNA، في
+
+372
+00:35:42,730 --> 00:35:52,930
+أسئلة ثانية؟ إيش يا بالي لسان؟ باي لسان؟ إيش دكتور
+
+373
+00:35:52,930 --> 00:35:57,900
+أحمد؟ خليها تتكلم، أو اسمع منكم إذا في أسئلة ثانية
+
+374
+00:35:57,900 --> 00:36:04,460
+في
+
+375
+00:36:04,460 --> 00:36:11,100
+أسئلة؟ اتفضل يا بالي لسان، إذا كان في سؤال، خلاص،
+
+376
+00:36:11,100 --> 00:36:17,000
+تمام، بالخطأ، مش مشكلة، مش مشكلة، بالنسبة لـ… الآن
+
+377
+00:36:17,000 --> 00:36:23,440
+يعني حكينا يعني ليش ربنا حطه فينا بهذا الشكل،
+
+378
+00:36:23,440 --> 00:36:31,790
+بالنسبة للـ DNA، إنك بتقدر تستنسخ بشكل دقيق وثابت
+
+379
+00:36:31,790 --> 00:36:41,590
+ومحدد تماماً، قضية إنه نسخة واحدة من الـ DNA زي
+
+380
+00:36:41,590 --> 00:36:46,150
+القطعة اللي فوق، عندما تحتاج أو في مرحلة معينة،
+
+381
+00:36:46,150 --> 00:36:53,790
+بتفرط الخشبتين تبع السلم اللولبي عن بعض، بتقدر
+
+382
+00:36:53,790 --> 00:37:02,030
+تعيد بناءهم كامل مكمل زي ما كان في الأساس من خلال
+
+383
+00:37:02,030 --> 00:37:07,750
+الاحتفاظ بنفس العلاقات بين القواعد النيتروجينية،
+
+384
+00:37:07,750 --> 00:37:16,190
+الـ A قبالها الـ T، والـ C قبالها الـ G، وكل يعني
+
+385
+00:37:16,190 --> 00:37:26,770
+backbone أو كل خط من هدول، ترتيب الـ… الأحماض أو
+
+386
+00:37:26,770 --> 00:37:33,010
+الترتيب القواعد النيتروجينية هنا يحفظ تماماً، والـ…
+
+387
+00:37:33,010 --> 00:37:39,230
+والإيش الناقص بيتمم بالترتيب كامل بحيث بنسبة عالية
+
+388
+00:37:39,230 --> 00:37:46,990
+جداً جداً بتم استنساخ الـ DNA بحيث يكون بشكل كامل،
+
+389
+00:37:46,990 --> 00:37:56,070
+بشكل متطابق تماماً، فـ يعني هذا سر في قضية حفظ
+
+390
+00:37:5
+
+445
+00:43:12,520 --> 00:43:17,880
+وأكثر وأكثر كلما أكبرت، بتشوف إنه فيه اسمه بيسموه
+
+446
+00:43:17,880 --> 00:43:23,020
+«نيكليوزوم فايبر»، وبعدين اسمه «سلينويد»، ماشي،
+
+447
+00:43:23,020 --> 00:43:28,520
+وبعدين اللي هي الـ «سيلز إنترفيس»، interface،
+
+448
+00:43:28,520 --> 00:43:33,580
+وبتكون الأمور بهذا الشكل، الموضوع يعني حتى تتخيلوا
+
+449
+00:43:33,580 --> 00:43:41,910
+إنه لما أنا في خلية، بدي أسوي عملية اللي بدنا
+
+450
+00:43:41,910 --> 00:43:46,510
+نتاخدها بعدين اللي هي عملية تحويل الـ DNA المادة
+
+451
+00:43:46,510 --> 00:43:51,270
+أو المعلومات اللي في الـ DNA أحولها لـ RNA بسميها
+
+452
+00:43:51,270 --> 00:43:56,430
+Transcription وبعدين لما أحول المادة أو المعلومات
+
+453
+00:43:56,430 --> 00:44:01,470
+اللي موجودة في الـ RNA لبروتين أسميها عملية
+
+454
+00:44:01,470 --> 00:44:05,250
+Translation فحتى أعمل عملية الـ Transcription هذه
+
+455
+00:44:05,250 --> 00:44:11,530
+بدي أخد قطعة من الـ «جين» من الـ «DNA» وأفرطها
+
+456
+00:44:11,530 --> 00:44:16,490
+شوية، السلسلة من اللي حكينا عنه، بدي أبعده شوية عن بعض
+
+457
+00:44:16,490 --> 00:44:21,950
+وبدي أنقل المعلومات اللي موجودة على جهة عن طريق
+
+458
+00:44:21,950 --> 00:44:27,590
+Messenger RNA وبدي أسوي عملية Transcription هذه
+
+459
+00:44:27,590 --> 00:44:34,310
+بدي تكون الـ «DNA» مفرود، بدي تكون الـ «DNA» بعيد عن
+
+460
+00:44:34,310 --> 00:44:40,930
+بعضه ومفرد، أما لما بدي أجي أعمل عملية زي قضية الـ
+
+461
+00:44:40,930 --> 00:44:48,070
+Cell Division حتى إذا أنت بتتخيل معاك مثلاً اللي هم
+
+462
+00:44:48,070 --> 00:44:55,310
+اللي بيشتغلوا الحياكة بالسنارة، وبيكون معاهم خيط
+
+463
+00:44:55,310 --> 00:45:02,470
+ماشي، إذا بدي أفصل مجموعة خيطين، كرتين خيطان عن بعض
+
+464
+00:45:02,470 --> 00:45:09,540
+لو الخيط هيك ملتف ومفرود، راح تلاقي أنه صعب
+
+465
+00:45:09,540 --> 00:45:14,420
+جداً تفصلن عن بعض، بس لو أسير ألف الخيط لحيث أنه
+
+466
+00:45:14,420 --> 00:45:21,760
+أعمله بشكل، أعمله بشكل كتلة متماسكة ومربوطة على
+
+467
+00:45:21,760 --> 00:45:26,600
+بعض، بيصير أن أفصل اثنتين هدول عن بعض سهل جداً، ففي
+
+468
+00:45:26,600 --> 00:45:32,730
+حالة إنه بيكون الواحد بيشتغل على الـ DNA وبأخد منه
+
+469
+00:45:32,730 --> 00:45:35,470
+البروتينات، وبأخد منه المعلومات وبسوّيله
+
+470
+00:45:35,470 --> 00:45:39,970
+Transcription وTranslation والأشياء هذه، بدي يكون
+
+471
+00:45:39,970 --> 00:45:44,590
+الـ DNA مفرود، وهي بيكون في مرحلة اللي بتسميها
+
+472
+00:45:44,590 --> 00:45:49,570
+Interface بتكون في المرحلة الخلية بتشتغل على الـ
+
+473
+00:45:49,570 --> 00:45:53,490
+DNA، بتشغل الـ DNA وجيناته، وبتسوي الأشياء اللي
+
+474
+00:45:53,490 --> 00:45:59,570
+مطلوبة منه، بس في لحظة معينة لما تتكلم عن إنه أنا
+
+475
+00:45:59,570 --> 00:46:05,450
+ما بدي الـ DNA هذا أشتغل عليه، بهمني أن يكون الكروموزوم
+
+476
+00:46:05,450 --> 00:46:11,310
+مطبوع بالذات في وقت الـ Cell Division بيكون... ما
+
+477
+00:46:11,310 --> 00:46:17,850
+هو اسمه؟ بيكون... يعني Condensed، بيكون مكثف، بيكون
+
+478
+00:46:17,850 --> 00:46:24,510
+مربوط على بعض، واضح؟ فيه إشي فيه حد مش فاهم؟ فيه حد
+
+479
+00:46:24,510 --> 00:46:28,130
+عنده سؤال؟
+
+480
+00:46:28,130 --> 00:46:39,530
+واضح دكتور أحمد؟ إذا فيه حد عنده سؤال يسأل، فهذا
+
+481
+00:46:39,530 --> 00:46:48,350
+نتكلم، نسميه اللي هنا يعني التركيب أو درجات التعقيد،
+
+482
+00:46:48,350 --> 00:46:49,850
+تركيب أو
+
+483
+00:46:54,000 --> 00:46:59,220
+الـ Packaging يعني اللي هي تغليف الـ DNA في الـ
+
+484
+00:46:59,220 --> 00:47:04,640
+Chromosome البشري، فاللي بيبدأ من أنه الـ Double
+
+485
+00:47:04,640 --> 00:47:09,720
+Helix بعدين بيلف أكثر عن طريق الـ Histone، راح نحكي
+
+486
+00:47:09,720 --> 00:47:13,600
+عنه مرات، فيه له أهميات في أمراض وأحالات وأشياء
+
+487
+00:47:14,320 --> 00:47:19,180
+وبعدين بنشكله على شكل الـ Solenoid، الـ Solenoids
+
+488
+00:47:19,180 --> 00:47:25,980
+وبعدين بيكون موجود سواء في حالة الـ Interface أو
+
+489
+00:47:25,980 --> 00:47:29,580
+في حالة لما نعمل الـ Cell Division، لقضية أن عندي
+
+490
+00:47:29,580 --> 00:47:34,680
+يكون كروموزومات مثبتة على بعض، بتغليف معين، بترتيب
+
+491
+00:47:34,680 --> 00:47:39,920
+معين، في أسئلة؟ ‏- سيهم، عندها سؤال ‏- أه، اسألي
+
+492
+00:47:41,510 --> 00:47:46,170
+بتسأل إنه كيف بيكون مفكوك في انقسام الخلية، أعتقد
+
+493
+00:47:46,170 --> 00:47:51,890
+جزء عن الـ«نيكليوزوم فايبر» يعني، أو بشكل عام
+
+494
+00:47:51,890 --> 00:47:57,110
+الـDNA، واحنا لازم نقسمها لخليتين، لأ، لأ، لأ، أنتِ
+
+495
+00:47:57,110 --> 00:48:06,930
+الآن الـDNA بيكون بين حالتين، في حالة بدي أقرا
+
+496
+00:48:06,930 --> 00:48:11,230
+المادة اللي فيه عشان أسوي بروتين، الخلية هذه بدهيها
+
+497
+00:48:11,880 --> 00:48:16,900
+فعشان تقراه، راح ناخد بعد شوية، راح يكون إنه لازم
+
+498
+00:48:16,900 --> 00:48:22,360
+الـ DNA هذا يكون مفرود، يعني لازم يكون حتى الـ
+
+499
+00:48:22,360 --> 00:48:27,480
+Double Strand هذا اللي هو هنا لازم يكون نفصله عن
+
+500
+00:48:27,480 --> 00:48:32,820
+بعض عشان تعرف نصل إليه، يعني هذه الـ ... الـ ... الـ
+
+501
+00:48:32,820 --> 00:48:37,460
+chromosome الواحد راح ناخد ما لا يقل عن ألف gene
+
+502
+00:48:37,460 --> 00:48:41,750
+فيه، يعني بيكون فيه عدد كبير من الجينات، مش كلها
+
+503
+00:48:41,750 --> 00:48:46,910
+شغالة، مش كلها بده يتم يعني عملية الـ Transcription
+
+504
+00:48:46,910 --> 00:48:52,330
+تبعتها لـ RNA، بده يكون عدد قليل، بس اللي شو اسمه
+
+505
+00:48:52,330 --> 00:48:57,510
+محتاج الـ DNA اللي يعني بتصير عملية الـ
+
+506
+00:48:57,510 --> 00:49:02,250
+Transcription، يعني في أي خلية عدد قليل من الجينات
+
+507
+00:49:02,250 --> 00:49:05,610
+بتتم قراءتها، اللي هي عملية الـ Transcription
+
+508
+00:49:05,610 --> 00:49:09,640
+تبعتها، فلما أنا بدي أعمل Transcription بدي أكون
+
+509
+00:49:09,640 --> 00:49:14,120
+مفرد زي هيك، بس لما أجي أعمل عملية cell division
+
+510
+00:49:14,120 --> 00:49:20,460
+بدي أكون مضغوط بشكل مظبوط، بشكل بحيث أنه أفصله عن بعض
+
+511
+00:49:20,460 --> 00:49:27,140
+كقطعتين، فهنجي ناخد صورة عنها، في واضحة؟ لسه عن
+
+512
+00:49:27,140 --> 00:49:30,800
+سياق المشكلة؟
+
+513
+00:49:30,800 --> 00:49:39,160
+لأ لأ، الأمور واضحة بالنسبة لها، يعني هذه صورة
+
+514
+00:49:39,160 --> 00:49:46,600
+بالنسبة لكيف تركيب الأمور، لما ناخد الـ Chromosome
+
+515
+00:49:46,600 --> 00:49:52,180
+الـ Chromosome يعني تقريباً راح ناخد أوصافه
+
+516
+00:49:52,180 --> 00:49:58,690
+وأشكاله، وكذالك، الشكل بالأخير يعني ممكن يكون على
+
+517
+00:49:58,690 --> 00:50:06,670
+شكل حبل طويل وهكذا، ولما نأخذه بشكل اللي هو عند
+
+518
+00:50:06,670 --> 00:50:11,810
+اللي بيسموه في الـ Karyotype، من اللي بيسموه عند
+
+519
+00:50:11,810 --> 00:50:19,150
+دراسة الكروموزومات تبع الإنسان بشكل كبير، فاحنا ناخد
+
+520
+00:50:19,150 --> 00:50:24,390
+على شكل واحدة هذه الدراسات، بيكون لو أخذنا هذا الـ
+
+521
+00:50:24,390 --> 00:50:27,690
+Chromosome ويكون بهذا الشكل، فيه إشي بيسموه
+
+522
+00:50:27,690 --> 00:50:32,150
+Centromere اللي هي النقطة الأهم في قضية فصل
+
+523
+00:50:32,150 --> 00:50:36,470
+القطعتين عن بعض، اللي هي بتداخل مع الـ Centrosome
+
+524
+00:50:36,470 --> 00:50:44,230
+وبيفصل الـ Two copies of DNA عن بعض، لما نيجي ناخد
+
+525
+00:50:44,230 --> 00:50:49,190
+شكله عن طريق، هنا شكلها Electron Microscopy اللي
+
+526
+00:50:49,190 --> 00:50:53,440
+أقربها بالأخير عبارة عن خاتم، لو جيت على قطعة
+
+527
+00:50:53,440 --> 00:50:57,560
+صغيرة من هذه الخيط، راح ألاقيها زي هيك، دي عندي الـ
+
+528
+00:50:57,560 --> 00:51:02,280
+Double Helix، الـ Double Helix يعني تلمّ، لو لبيه
+
+529
+00:51:02,280 --> 00:51:11,360
+بينهم دعائم بتكون بنفس الترتيب، فالأصل تكون مثلاً،
+
+530
+00:51:11,360 --> 00:51:17,960
+هاي على، وبناخدها إنه أنا بقرا من الطرف رقم خمسة
+
+531
+00:51:17,960 --> 00:51:22,250
+«5 Prime» لـ «3 Prime»، الطرف الثاني راح يكون من
+
+532
+00:51:22,250 --> 00:51:25,630
+الـ5 Prime لـ3 Prime، بيكون هذا هو شكل
+
+533
+00:51:25,630 --> 00:51:31,530
+الـDeoxyribose، زي الفوسفيل، أما بالنصف بيكون
+
+534
+00:51:31,530 --> 00:51:36,270
+الـNitrogen Bases، فهذه لما نقول إحنا قرينا
+
+535
+00:51:36,270 --> 00:51:42,390
+الـSequencing تبع الـDNA، بنقول شو هي الأحرف تبعات
+
+536
+00:51:42,390 --> 00:51:49,580
+الـNitrogen Bases الموجود، وعادة بناخدها دايماً من
+
+537
+00:51:49,580 --> 00:51:55,520
+الـ5 للـ3، هيك المتعارف عليه، أساس إن الـ3 للـ5
+
+538
+00:51:55,520 --> 00:52:02,460
+بيكون أسرع، ماشي؟ فلو أخذنا إنه أنا عندي بني آدم
+
+539
+00:52:02,460 --> 00:52:08,320
+معين، اللي عملوله Human Genome، شو اسمه الـHuman
+
+540
+00:52:08,320 --> 00:52:14,320
+Genome، للقطعة هذه في الـChromosome هذا، للبروتين،
+
+541
+00:52:14,320 --> 00:52:19,490
+الله أعلم شو اللي راح يكون، يطلعه، بأخد، آسف، بأخد
+
+542
+00:52:19,490 --> 00:52:23,910
+إنه هذا هو الـ Double Helix، وهكذا يكون الـ
+
+543
+00:52:23,910 --> 00:52:28,410
+Reference Sequence، لما نتعامل إحنا كعلماء وأطباء
+
+544
+00:52:28,410 --> 00:52:31,850
+نيجي مثلاً نتناقش بعد شوية على «حمى البحر الأبيض المتوسط»
+
+545
+00:52:31,850 --> 00:52:36,150
+الـMediterranean fever، ولا أي مرض وراثي ثاني،
+
+546
+00:52:36,150 --> 00:52:39,370
+بتلاقي لما نقول على القطعة هذه، وشو هو الـReference
+
+547
+00:52:39,370 --> 00:52:44,260
+Sequence اللي إحنا بنستخدمه، تلقائياً راح ناخد عشان
+
+548
+00:52:44,260 --> 00:52:48,160
+ما أتعقدش الموضوع، من الخمسة إلى الثلاثة، فدايماً
+
+549
+00:52:48,160 --> 00:52:52,760
+بقراهم من الخمسة إلى الثلاثة، فهنا عملوا تجربة إنه
+
+550
+00:52:52,760 --> 00:52:57,700
+جابوا خمسة أشخاص، درسوا
+
+551
+00:52:57,700 --> 00:53:04,400
+هذه القطعة، وشافوا الـSequence تبعها، ولقوا إنه في
+
+552
+00:53:04,400 --> 00:53:09,720
+حالة مثلاً، الشخص الأول كان اللي هو الـReference
+
+553
+00:53:09,720 --> 00:53:14,180
+Sequence، وكان هو أول إنسان إحنا درسناه، فما جيبنا
+
+554
+00:53:14,180 --> 00:53:18,720
+بني آدم ثاني، وعندي هسا إمكانيات إني أدرس
+
+555
+00:53:18,720 --> 00:53:26,020
+الاختلافات، الـ Polymorphism اللي هي الـ الـ الـ
+
+556
+00:53:26,020 --> 00:53:31,240
+يعني الاختلافات حتى على مستوى single nitrogen
+
+557
+00:53:31,240 --> 00:53:36,780
+bases، فبحيث إنه الشخص الأول والشخص الثاني في هذا
+
+558
+00:53:36,780 --> 00:53:41,620
+المكان، بدل ما هي الـT زي ما هو بالـReference، في C
+
+559
+00:53:41,620 --> 00:53:48,110
+و C، فهذه طبعاً الـ «T» بيكون إقبالها «A»، فلما يكون
+
+560
+00:53:48,110 --> 00:53:53,750
+هنا «C» بيكون إقبالها «G»، فهذول Individual 2، 3
+
+561
+00:53:53,750 --> 00:53:57,850
+عندهم هذا الخلل في هذا المكان، بقول على الموقع،
+
+562
+00:53:57,850 --> 00:54:04,310
+هذا بسميه 1، 2، 3، 4، 5، 6، 7، هنا رقم 8، هنا رقم
+
+563
+00:54:04,310 --> 00:54:14,080
+مثلاً 20، بدل ما هي «C» كانت «A»، الشخص الخامس تم
+
+564
+00:54:14,080 --> 00:54:21,320
+إزالة اثنين نيكليوتيد أو اثنين Bases، بحيث إن الـ
+
+565
+00:54:21,320 --> 00:54:27,020
+«T» أجت بعد «C»، فهي أقصر طبعاً، هنا بيحاولوا إنه،
+
+566
+00:54:27,020 --> 00:54:34,440
+شو اسمه، يعني هذه الأخيرة زي ما هم شرحين لكم هنا،
+
+567
+00:54:34,440 --> 00:54:40,620
+هنا صار «Deletion»، يعني لسبب أو لآخر انقطع الـ Two
+
+568
+00:54:40,620 --> 00:54:44,300
+Nucleotides، إن شاء الله، فالـ T أجت وراها بعدها الـ
+
+569
+00:54:44,300 --> 00:54:48,300
+C، يعني هاي الـ T أجت بدل ما يكون فيه Two Ts بعدها
+
+570
+00:54:48,300 --> 00:54:52,120
+من تاني، تيات، أجت بعدها الـ C مباشرة، فالمفروض هذا
+
+571
+00:54:52,120 --> 00:54:57,840
+يكون شكله أصغر، فهذا بيعمل برضه خاصية وراثية أخرى
+
+572
+00:54:57,840 --> 00:55:03,640
+فالمطلوب هنا، أو الفكرة اللي بيشرحوها هنا إنه
+
+573
+00:55:03,640 --> 00:55:07,360
+الترتيب
+
+574
+00:55:09,120 --> 00:55:17,620
+القواعد النيتروجينية في الـ DNA هو ما يتحكم
+
+575
+00:55:17,620 --> 00:55:22,880
+بالأحرف أو الـ Amino Acids اللي راح تيجي بالبروتين
+
+576
+00:55:22,880 --> 00:55:29,380
+اللي راح تيجي في الـ اللي تمثل المادة الوراثية
+
+577
+00:55:29,380 --> 00:55:40,160
+وتمثل المظهر الخارجي بعدين لأي كل إنسان، ففي حد
+
+578
+00:55:40,160 --> 00:55:46,040
+بيسأل سؤال، يلّا إذا في أسئلة، شو السؤال؟ أنا مش شايف
+
+579
+00:55:46,040 --> 00:55:56,860
+الـChat، وحتى صورتي راحت، آه، في سؤال؟
+
+580
+00:55:56,860 --> 00:56:07,100
+في واحد رفع إيده، كريم، دكتور أحمد،
+
+581
+00:56:14,510 --> 00:56:19,670
+الدكتور أحمد، في حد عنده سؤال، أنا أشوف إذا في الـ
+
+582
+00:56:19,670 --> 00:56:39,930
+«تشات»، وين الـ«تشات»؟ ماشي،
+
+583
+00:56:39,930 --> 00:56:48,140
+أحياناً يعني مش ضروري الإنسان الأول هو يكون، شو
+
+584
+00:56:48,140 --> 00:56:54,160
+اسمه؟ هو السليم، والثاني مصاب، إحنا هنا الفكرة إنه
+
+585
+00:56:54,160 --> 00:57:02,340
+أنا من دراستي لتركيب الـDNA، بسوي Sequence لإيش هم،
+
+586
+00:57:02,340 --> 00:57:07,960
+ليه، واحدة من أربعة من الـNitrogen Bases
+
+587
+00:57:07,960 --> 00:57:11,420
+الـNitrogen Bases، دو بالأخير هم اللي بتحكموا
+
+588
+00:57:11,420 --> 00:57:19,520
+بالبروتين، فلما أنا آجي أدرس مثلاً نفترض أنه بدي أدرس
+
+589
+00:57:19,520 --> 00:57:24,940
+الـ gene تبع الـ Alpha chain تبع الـ hemoglobin
+
+590
+00:57:24,940 --> 00:57:33,320
+فبروح بشوف إنسان مثلاً، الشخص الأول مثلاً اللي هو
+
+591
+00:57:33,320 --> 00:57:37,120
+«باعتبره أنه كان طبيعي»، «والإنسان اللي ماعندوش
+
+592
+00:57:37,120 --> 00:57:41,460
+مشكلة»، «وباعتبره طبيعي»، يعني أحياناً الـReference
+
+593
+00:57:41,460 --> 00:57:45,480
+Sequence هذا ممكن يكون لإنسان مريض أو إنسان طبيعي
+
+594
+00:57:45,480 --> 00:57:50,000
+بس هو الأول اللي اعتمدنا عليه في دراسة هذه القطعة
+
+595
+00:57:50,000 --> 00:57:54,900
+من الـDNA، يعني هذه الفكرة الأولى، فإذا أنا الإنسان
+
+596
+00:57:54,900 --> 00:58:02,110
+الأول كان بهذا الشكل، وبعدين بدرس شخص ثاني وثالث
+
+597
+00:58:02,110 --> 00:58:07,170
+ورابع وخامس وعشرة ومليون ومليونين، بقدر أدرس،
+
+598
+00:58:07,170 --> 00:58:13,650
+بشوف شو الاختلافات، وبتكون إنه أنا في الأصل في
+
+599
+00:58:13,650 --> 00:58:22,230
+الغالب العمود الفقري تبع ترتيب الـ «جين» هذا لهذا
+
+600
+00:58:22,230 --> 00:58:28,950
+البروتين بكون بشكل معين، فبعتبره الأساس، لما أجي
+
+601
+00:58:28,950 --> 00:58:35,750
+أسوي report لـ الـ reference sequence هذا هو تبع
+
+602
+00:58:35,750 --> 00:58:42,230
+أول إنسان درسناه، أو أول إنسان سويت له sequence على
+
+603
+00:58:42,230 --> 00:58:48,510
+افتراض أنه إنسان طبيعي، فلما أجي أجيب لإنسان ثاني
+
+604
+00:58:48,510 --> 00:58:54,380
+وهنا أنا سويت لأربعة غيره، لاقيت إنه Okay، هذا
+
+605
+00:58:54,380 --> 00:58:58,320
+الإنسان الأول بهذا الشكل، فيه شخصين كان عندهم
+
+606
+00:58:58,320 --> 00:59:03,540
+بيسموه Single Nucleotide Polymorphism، يعني فيه
+
+607
+00:59:03,540 --> 00:59:11,700
+اختلاف في موقع معين، لحرف تبع الـNitrogen Base، وفي
+
+608
+00:59:11,700 --> 00:59:17,180
+شخص رابع عنده اختلاف في محل ثاني بنوعية أخرى، وفي
+
+609
+00:59:17,180 --> 00:59:22,960
+شخص خامس، كان... ما هو اسمه؟ حتى فيه الـDeletion
+
+610
+00:59:22,960 --> 00:59:26,580
+فطبعاً الـDeletion راح تقصر، راح تغير كله، راح
+
+611
+00:59:26,580 --> 00:59:32,020
+تتغير بشكل كبير، يعني يمكن الاختلافات اللي موجودة
+
+612
+00:59:32,020 --> 00:59:38,260
+عند 2 و3 و4 اختلافات بسيطة، يمكن ما تكونش مؤثرة
+
+613
+00:59:38,
+
+667
+01:04:41,530 --> 01:04:44,750
+الحماية من الـ mutation يعني لو صار خراب في هذا
+
+668
+01:04:44,750 --> 01:04:48,190
+الجزء ما هو non-coding، مش مهم كثير، من ناحية
+
+669
+01:04:48,190 --> 01:04:54,710
+والناحية الثانية أنه بتحكم في أيّ خلية نشغل هذا
+
+670
+01:04:54,710 --> 01:04:59,210
+الـ gene يعني هيك،  في حالة أخرى فالآن اللي
+
+671
+01:04:59,210 --> 01:05:07,000
+قدامنا يعني إنه على العكس، الـ single nucleotide الـ
+
+672
+01:05:07,000 --> 01:05:14,780
+Polymorphism اللي هي هذه الظاهرة في هذه الرسمة،
+
+673
+01:05:14,780 --> 01:05:19,000
+علاقة شائعة جداً جداً، ومرات ما لهاش قيمة يعني لأنه
+
+674
+01:05:19,000 --> 01:05:23,540
+راح ناخد بعد شوية الـ Triplets هدولة اللي هي كل
+
+675
+01:05:23,540 --> 01:05:26,380
+ثلاثة نيوكليوتات بيعطينا واحد Amino Acid زي ما
+
+676
+01:05:26,380 --> 01:05:31,400
+بتعرفوا، هذه بتتم من خلال أن أحيانًا أكثر من
+
+677
+01:05:31,400 --> 01:05:33,240
+Triplet، لأنه
+
+678
+01:05:41,210 --> 01:05:42,610
+4×4×4×4×4×4×4×4×4×4×4×4×4×4×4×4×4×4×4×4×4×4×4×4×4×4
+
+679
+01:05:44,260 --> 01:05:48,260
+فيه سؤال آخر؟ دكتور، في المعظم يعني بيقول إيش
+
+680
+01:05:48,260 --> 01:05:53,080
+الفكرة اللي بده يوصلها الـ slide؟ يعني هي قضية
+
+681
+01:05:53,080 --> 01:05:57,180
+الـ Reference Sequence بناخده إحنا عن أحد
+
+682
+01:05:57,180 --> 01:05:59,960
+الـ strands تبعه، اللي هو الـ Double Helical، بيشكل
+
+683
+01:05:59,960 --> 01:06:02,840
+كروموزوم، وبيطلع عندنا فيه اختلافات ما بين
+
+684
+01:06:02,840 --> 01:06:05,880
+الـ individuals مع الـ Reference Sequence، إيش الفكرة
+
+685
+01:06:05,880 --> 01:06:09,700
+اللي أنا بدي أوصلها، يعني المعلومة اللي بدي أوصلها
+
+686
+01:06:09,700 --> 01:06:13,380
+الـ slide بشكل عام؟ هو هيك السؤال، يعني، آه، الفكرة
+
+687
+01:06:13,380 --> 01:06:21,200
+أنه لما أنا في العلم لما بدأت أدرس موضوع، بدأت القضية
+
+688
+01:06:21,200 --> 01:06:25,360
+حكينا من قبل، اسم الـ Human Genome، الـ Human Genome
+
+689
+01:06:25,360 --> 01:06:30,000
+أخذوا بني آدم واحد، فأنت بدأت تبدأ في مرحلة معينة،
+
+690
+01:06:30,000 --> 01:06:33,940
+فلما تبدأ، أخذنا الـ Human Genome، أنا أظن يعني هاي
+
+691
+01:06:33,940 --> 01:06:39,500
+واحدة ذكرلي إياها كمعلومة، إنه الإنسان ما هو، بدك تاخد
+
+692
+01:06:39,500 --> 01:06:43,700
+إنسان واحد، لأن كلنا مختلفين عن بعض، شايف عليّ؟  ناخد
+
+693
+01:06:43,700 --> 01:06:46,900
+مادة وراثية من الأب ومن الأم ومن الـ Mitochondria
+
+694
+01:06:46,900 --> 01:06:51,660
+لوحده وكذا، أنا أظن سمعت إنه بيقولوا إنه مدير
+
+695
+01:06:51,660 --> 01:07:01,380
+البنك الدولي اللي هو مول بمليارات المشروع
+
+696
+01:07:01,380 --> 01:07:04,700
+الـ Human Genome، هو الإنسان اللي أخذوا الـ DNA
+
+697
+01:07:04,700 --> 01:07:09,950
+تبعه، أنت بدك تبدأ في لحظة معينة، كيف بدك يعني من وين
+
+698
+01:07:09,950 --> 01:07:15,250
+بدك تعرف أنه يعني بدو يكون عندك مرجع بالأول ترجع له،
+
+699
+01:07:15,250 --> 01:07:19,470
+تقيس باقي الأشياء عليه، يمكن هذا الإنسان هو عنده
+
+700
+01:07:19,470 --> 01:07:23,610
+أمراضه، عنده اختلافات معينة عن غيره، فهل
+
+701
+01:07:23,610 --> 01:07:26,530
+الـ Reference Sequence هو شيء، شيء دائماً ما بعرف
+
+702
+01:07:26,530 --> 01:07:32,350
+يعني ما عندي معلومة إنه هو شيء طبيعي، يعني ما في شيء
+
+703
+01:07:32,350 --> 01:07:37,820
+اسمه طبيعي، بينما كل إنسان له ميزات معينة، فلما
+
+704
+01:07:37,820 --> 01:07:42,520
+انتوا، الواحد بعدين راح ياخد، كيف ببحث في المواضيع
+
+705
+01:07:42,520 --> 01:07:47,540
+هذه، وبسوي Blast، وبسوي بعد الـ Sequencing، أو بستخدم
+
+706
+01:07:47,540 --> 01:07:52,440
+PCR وكده، لما أنت تقيم هذا الموضوع، بدخل على قواعد
+
+707
+01:07:52,440 --> 01:07:57,420
+البيانات تبع الترتيب، الـ Sequence هذا، بشوف هذا
+
+708
+01:07:57,420 --> 01:08:04,290
+بيشبه إيش، وبصير أقارنه فيه، فلازم أنا بالأول آخذ أي
+
+709
+01:08:04,290 --> 01:08:09,550
+جين أو أي مكان سيكوينس معين، بصير أعتبره هذا هو
+
+710
+01:08:09,550 --> 01:08:15,090
+الـ Reference، وبصير بعدين أشوف لما آخذ حالي ثاني، أو
+
+711
+01:08:15,090 --> 01:08:21,010
+شخص آخر أو إنسان آخر، بشوف قد إيش درجة الاختلافات،
+
+712
+01:08:21,010 --> 01:08:27,390
+وبقيم وضع هذه القطعة من الـ DNA أو هذا الجين، آه،
+
+713
+01:08:27,390 --> 01:08:33,290
+واضح؟ يا دكاترة، أو يا دكتور، إذا كانت الصورة واضحة، أو
+
+714
+01:08:33,290 --> 01:08:38,890
+المطلوب من الـ slide واضح، يعني بنكمل، اسألوا مرة
+
+715
+01:08:38,890 --> 01:08:42,690
+ثانية، ما في مشكلة، الدكتور طبعاً ما عنده مشكلة
+
+716
+01:08:42,690 --> 01:08:49,550
+أنه يوضح النقطة بالزيادة، الـ Human Genome بس انتهى،
+
+717
+01:08:49,550 --> 01:08:55,210
+يعني هو البداية، والكلام من سنة الـ، يعني خلص يمكن
+
+718
+01:08:55,210 --> 01:09:01,030
+أظن 2003، 2004 إنه عملوا الـ Sequence لكل إنسان
+
+719
+01:09:01,030 --> 01:09:06,030
+واحد، واعتبروه هو Reference Sequence، فلما واحد
+
+720
+01:09:06,030 --> 01:09:12,530
+يدرس، يعني أنا لما أجي مثلاً أدرس ظاهرة معينة في
+
+721
+01:09:12,530 --> 01:09:18,010
+المناعة مثلاً، بلاقي مرات بروتين، باكتشف بروتين
+
+722
+01:09:18,010 --> 01:09:18,510
+جديد،
+
+723
+01:09:21,620 --> 01:09:26,300
+بحاول أشوف شو كان الـ DNA Sequence اللي بعطينا
+
+724
+01:09:26,300 --> 01:09:32,740
+هذا البروتين، لما أفهم وأقدر ألاقي وين هذا الشيء
+
+725
+01:09:32,740 --> 01:09:38,900
+موجود في الـ Chromosome وفي الـ DNA، بسير بعدين
+
+726
+01:09:38,900 --> 01:09:46,060
+مرحلة أخرى متقدمة أكثر، ألاحظ شو هي اختلافات البشر
+
+727
+01:09:46,060 --> 01:09:53,060
+عموماً عن الـ Standard أو عن الـ Reference، فبصير أنا
+
+728
+01:09:53,060 --> 01:09:56,980
+في حالات أمراض، في حالات عائلات، في حالات يعني مش
+
+729
+01:09:56,980 --> 01:10:00,600
+ضروري individual one ولا two، three، أن يكون مريض،
+
+730
+01:10:00,600 --> 01:10:05,160
+ممكن يكون، لأ، هي بس أنه في اختلافات، يعني إنه هذه
+
+731
+01:10:05,160 --> 01:10:11,540
+ظاهرة موجودة، قد إيش نسبتها 100% بالنسبة للدراسات،
+
+732
+01:10:11,540 --> 01:10:17,510
+لإيش هي والله أنا ما بعرف، يعني إنها بالكم يعني، طب
+
+733
+01:10:17,510 --> 01:10:21,570
+يا دكتور أنا بدي أنقل سؤال وبدي أسأل أنا برضه
+
+734
+01:10:21,570 --> 01:10:27,210
+سؤال، بقيت بقضية الـ Reference Sequence، مثلاً الشخص
+
+735
+01:10:27,210 --> 01:10:33,670
+اللي تم أخذه لعملية الـ Genome Sequencing، هل تم
+
+736
+01:10:33,670 --> 01:10:39,330
+افتراض أنه هو الـ Normal؟ يعني ما تستطيع أن تقول
+
+737
+01:10:39,330 --> 01:10:44,930
+أنه هو الـ Normal؟ آه صحيح، وممكن
+
+738
+01:10:44,930 --> 01:10:51,810
+يكون في عَضل جينات لأمراض، لكن ما تم ترجمتها، أو
+
+739
+01:10:51,810 --> 01:10:56,270
+غير ظاهرة، فبالتالي الـ Reference، آه صحيح، يعني
+
+740
+01:10:56,270 --> 01:10:59,890
+السؤال، هل الـ reference هو اللي هيكون مرجع
+
+741
+01:10:59,890 --> 01:11:04,750
+لدراسة، بس مقارنة ومشابهة، مش مرجع إنه نقول ما ..
+
+742
+01:11:04,750 --> 01:11:09,170
+ما .. عقل، ما بقدر أقول إن هذا إنسان سليم، وغيره هو
+
+743
+01:11:09,170 --> 01:11:15,230
+إنسان مريض، لأ، ما مش إيه، بس كـ .. لما تيجي تدرس
+
+744
+01:11:15,230 --> 01:11:22,190
+الـ .. يعني طبعاً إحنا بنتكلم عن حوالي خمس وعشرين
+
+745
+01:11:22,190 --> 01:11:27,680
+ألف gene، اللي هو اللي يعني بتوقعوا إنه فيه إلى
+
+746
+01:11:27,680 --> 01:11:32,260
+بيسموه الـ Promoter والـ End codon، واللي هي يعني
+
+747
+01:11:32,260 --> 01:11:36,120
+القطعة اللي بتتم ترجمتها من خلال الـ Transcription
+
+748
+01:11:36,120 --> 01:11:41,360
+للـ RNA وبعدين الـ Protein، فالقطع اللي زي هيك فيه
+
+749
+01:11:41,360 --> 01:11:47,360
+حوالي 25 ألف Gene، فالـ  الـ الآن النقطة اللي بدها
+
+750
+01:11:47,360 --> 01:11:57,600
+الواحد يوصلها، إنه لأغراض عملية، إيجاد مرجعية لدراسة هذه
+
+751
+01:11:57,600 --> 01:12:05,520
+المواضيع، تم عمل الـ Human Genome، ومنه بيتم يعني
+
+752
+01:12:05,520 --> 01:12:10,340
+افتراض Reference Sequence اللي هو لقوه عند الإنسان
+
+753
+01:12:10,340 --> 01:12:15,600
+الأول اللي درسوه، وبعدين بسير لما قاعد أدرس شخص
+
+754
+01:12:15,600 --> 01:12:20,260
+ثاني، ثالث، عائلة، عائلتين، الـ populations مثلاً، كل
+
+755
+01:12:20,260 --> 01:12:25,180
+البيض، السود، الصينيين، الـ كذا، الـ كذا، بسير أشوف
+
+756
+01:12:25,180 --> 01:12:30,180
+أنا فيه اختلافات بين الترتيب، اللي هي القواعد
+
+757
+01:12:30,180 --> 01:12:36,000
+النيتروجينية في الـ DNA، اللي ممكن تكون سبب في تغير
+
+758
+01:12:36,520 --> 01:12:42,320
+الصفات تبعات الـ بروتين، والصفات اللي بتظهر على
+
+759
+01:12:42,320 --> 01:12:48,960
+الإنسان، بعدين دكتور، في نقطة ثانية، إنه هل يمكن
+
+760
+01:12:48,960 --> 01:12:54,980
+افتراض إن غالبية اللي هو الـ جينوم، يعني مثلاً ما
+
+761
+01:12:54,980 --> 01:12:58,280
+بين الـ Reference وما بين individual one، يعني بشكل
+
+762
+01:12:58,280 --> 01:13:03,730
+عشوائي، إنه هل هيكون غالبية الـ جينوم متشابه؟ لكن
+
+763
+01:13:03,730 --> 01:13:08,110
+في اختلاف في 1% أو 2%، يعني الغالب هو المتشابه،
+
+764
+01:13:08,110 --> 01:13:11,690
+والاختلاف هو اللي هيكون أقل، لإنه في الـ سلايد،
+
+765
+01:13:11,690 --> 01:13:15,670
+يعني برضه في التعليق الـ Catching تحت الصورة،
+
+766
+01:13:15,670 --> 01:13:20,630
+كاتب إن الـ سيكوينس من DNA من مجموعة من الشخصيات،
+
+767
+01:13:20,630 --> 01:13:24,130
+هي متشابهة لكنها ليست متطابقة، يعني الغالب هو اللي
+
+768
+01:13:24,130 --> 01:13:27,890
+بكون متشابه، هذه النقطة اللي بتحكيها طبعاً يعني،
+
+769
+01:13:27,890 --> 01:13:37,330
+هذا لتسهيل عملية دراسة القطع المحددة، يعني أنا بصير
+
+770
+01:13:37,330 --> 01:13:41,710
+مثلاً، الواحد عنده Hemoglobinopathy، بصير بيدرس على
+
+771
+01:13:41,710 --> 01:13:46,350
+الـ الـ hemoglobin genes، الـ Alpha والـ Beta
+
+772
+01:13:46,350 --> 01:13:51,530
+chains، فبروِح على الـ DNA تبعهم، بحاول أسوي sequence
+
+773
+01:13:51,530 --> 01:13:55,850
+وبشوف مين إنسان مريض، مين إنسان طبيعي، بس حتى
+
+774
+01:13:55,850 --> 01:14:03,230
+أحياناً الطبيعيين، لما أنا أدرس الـ الـ الفرق بين
+
+775
+01:14:03,230 --> 01:14:06,550
+الـ Reference Sequence، اللي هي ما هو عشان أقدر
+
+776
+01:14:06,550 --> 01:14:11,830
+يعني الـ Reference Sequence بالأخير بيمثل شو بدي
+
+777
+01:14:11,830 --> 01:14:16,490
+أسميه، يعني خارطة الطريق، عشان تعرف وين أنت موجود
+
+778
+01:14:16,490 --> 01:14:25,310
+شايف عليّ؟ ضمن كمية الـ DNA هذه، فترتيب الأحرف هذول
+
+779
+01:14:25,310 --> 01:14:32,730
+هو اللي يعني بيمثل، أحيان كثيرة، قليلة، بتمكننا للوصول
+
+780
+01:14:32,730 --> 01:14:36,810
+لهذا الموقع، فما عليّ إلا إفادات، بس الفكرة اللي بدك
+
+781
+01:14:36,810 --> 01:14:42,370
+تاخدها، إنه مش كل إنسان، ما عدا الـ Identical Twins،
+
+782
+01:14:42,370 --> 01:14:50,710
+ماشي، الـ Identical Twins، آه، اللي بيكونوا شخصين
+
+783
+01:14:50,710 --> 01:14:57,910
+Completely Exact، أي شخصين آخرين غير ذلك، لما تيجي
+
+784
+01:14:57,910 --> 01:15:02,250
+تقارن بين الـ DNA تبعهم، بكون فيه اختلافات،
+
+785
+01:15:02,250 --> 01:15:06,990
+واختلافات أحياناً مش مهمة، يعني ما لهاش تأثير وظيفي
+
+786
+01:15:06,990 --> 01:15:11,670
+على الـ Protein، وأحياناً بتكون زي الـ Deletion،
+
+787
+01:15:11,670 --> 01:15:16,230
+لو الـ Deletion لثلاثة، بكون مش مهم كتير، بس لما
+
+788
+01:15:16,230 --> 01:15:20,610
+يكون واحد ولا اثنين، بيسموه Frame Shift، يعني
+
+789
+01:15:20,610 --> 01:15:25,450
+بيخربط لك الترتيب كله، فبالتالي، بكون تأثيره شديد
+
+790
+01:15:25,450 --> 01:15:30,320
+كتير أحياناً، راح ناخد إن الظواهر هذه، أنا ما نوقفش
+
+791
+01:15:30,320 --> 01:15:36,000
+كثير كثير، يعني فيه لأي قطعة الـ DNA، لما تتكلم
+
+792
+01:15:36,000 --> 01:15:41,060
+على، يعني هو إحنا مش بناخد التسع مليارات، وباجي،
+
+793
+01:15:41,060 --> 01:15:44,140
+بدي أقول واحد بالمية، اثنين بالمية، فرق ولا كده،
+
+794
+01:15:44,140 --> 01:15:47,980
+إحنا لما نيجي ندرس في الـ Genetics، بالأخير بدي
+
+795
+01:15:47,980 --> 01:15:51,720
+آخذ قطعة صغيرة، بدي آخذ القطعة اللي عند الـ
+
+796
+01:15:51,720 --> 01:15:55,910
+Protein اللي أنا مهتم فيه، اللي أنا بِدرسه، للظاهرة
+
+797
+01:15:55,910 --> 01:15:58,610
+اللي عندي، يا عم واحد عنده Hemoglobinopathy، بدي
+
+798
+01:15:58,610 --> 01:16:01,330
+تبقى الـ Hemoglobin ألف أو Beta Chain، بركز على
+
+799
+01:16:01,330 --> 01:16:06,310
+هذول، لما أنا آجي أدرس كظاهرة في Reference بتكون
+
+800
+01:16:06,310 --> 01:16:10,310
+برجع لقطع معينة، بيعتبروها هي الـ Reference،
+
+801
+01:16:10,310 --> 01:16:14,450
+Sequence، وبلاقي إن البشر لما أنا آجي أدرسهم في
+
+802
+01:16:14,450 --> 01:16:18,910
+الغالب راح يكون فيه أنواع مختلفة من الاختلافات، ما
+
+803
+01:16:18,910 --> 01:16:23,230
+عدا إذا Identical Twin للـ Reference، إذا هو فعلاً
+
+804
+01:16:23,640 --> 01:16:31,040
+قريب تماماً، راح يكون تماماً مثله، ماشي، في أسئلة،
+
+805
+01:16:31,040 --> 01:16:38,940
+أنا مضطر أوقف هنا، ساعة قريبة العشرة، أشوف
+
+806
+01:16:38,940 --> 01:16:49,320
+إذا نلحق، نتكلم، هنا يعني اللي عندنا
+
+807
+01:16:49,320 --> 01:16:57,300
+حوالي 22 زوج كروموزوم، وفي عندي الـ X والـ Y، الزوج تبع
+
+808
+01:16:57,300 --> 01:17:03,860
+الـ sex chromosomes، فلما نيجي نشوف صورتهم، هدول
+
+809
+01:17:03,860 --> 01:17:08,160
+اللي هي الـ Karyotype، بكون هيك أحجام الخلايا وهذا
+
+810
+01:17:08,160 --> 01:17:11,500
+بنحطه جسم الخلية بعضها، باخد الـ DNA أكثر على الـ
+
+811
+01:17:11,500 --> 01:17:21,040
+Histones وأشياء أقل، فيعني هنا مقارنة بين عدد
+
+812
+01:17:21,040 --> 01:17:27,560
+الكروموزومات، لحجم الكروموزومات، و الـ … الـ Density
+
+813
+01:17:27,560 --> 01:17:35,280
+تبعات الجينات، يعني الـ 25 ألف جين يعني،
+
+814
+01:17:35,280 --> 01:17:43,180
+هاي هنا ألفين جين، يعني اللي هو الـ Chromosome 1 فيه
+
+815
+01:17:43,180 --> 01:17:49,540
+حوالي ألفين جين، والأشياء زي الـ X والـ Y، الـ Y
+
+816
+01:17:49,540 --> 01:17:57,940
+قصدي، والـ 21 و 22 أصغر جينات، أصغر كروموزومات،
+
+817
+01:17:57,940 --> 01:18:02,840
+يكون عدد الجينات، بس بالمتوسط بيحكوا فيه حوالي ألف
+
+818
+01:18:02,840 --> 01:18:04,840
+جين في كل كروموزوم،
+
+819
+01:18:07,650 --> 01:18:11,750
+فيعني هو أنا بالأخير باعتبرها هذا الخط، أنه
+
+820
+01:18:11,750 --> 01:18:18,610
+تقريباً ستة، يعني سبعة تقريباً جينات في كل Mega Base،
+
+821
+01:18:18,610 --> 01:18:23,950
+اللي هو يعني مليون Base، يعني كل مليون Nucleotide
+
+822
+01:18:23,950 --> 01:18:29,970
+بعطيني تقريباً سبعة جينات، هيك يعني، بدنا نخطئ، فكل ما
+
+823
+01:18:29,970 --> 01:18:33,890
+كان حجم الـ Chromosome أكبر، عدد الجينات اللي فيه
+
+824
+01:18:33,890 --> 01:18:39,180
+أكبر، هي أسئلة، أنا مضطر أوقف، بنكمل من هيك للمرة
+
+825
+01:18:39,180 --> 01:18:45,350
+الجاية، تمام، دكتور، بس برضه يعني هو سؤال، يعني هو
+
+826
+01:18:45,350 --> 01:18:50,170
+تقريباً بيتعلق بالـ slide اللي قبل، دكتور، أسمح لي، إنه
+
+827
+01:18:50,170 --> 01:18:53,910
+الـ sequence، هو سؤال الـ sequence هذا بيكون لشخص
+
+828
+01:18:53,910 --> 01:18:57,450
+جيناته مثالية تقريباً، يعني بيصنع البروتينات بشكل
+
+829
+01:18:57,450 --> 01:19:01,470
+سليم، وأي اختلاف هيكون واحد بالمية، ممكن الاختلاف
+
+830
+01:19:01,470 --> 01:19:05,570
+يكون طفرة أو تباين بالصفات، لأ لأ، حسنًا خلّينا ما
+
+831
+01:19:05,570 --> 01:19:10,720
+ندخلش بهذا الموضوع، مش مقصود هذا الكلام، الفكرة كانت
+
+832
+01:19:10,720 --> 01:19:18,980
+التالي، لما بعد ما اكتشفنا الـ DNA وصرنا نعرف عنه،
+
+833
+01:19:18,980 --> 01:19:25,760
+الكلام قبل تقريباً 30 سنة، ماشي، كيف بدنا نحاول
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/Tl5zcdiL4_o_raw.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/Tl5zcdiL4_o_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..89fb89f9cbceab7e9234675b6f5bf103c1ffa90f
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/Tl5zcdiL4_o_raw.srt
@@ -0,0 +1,3528 @@
+1
+00:00:00,000 --> 00:00:08,880
+تعني بعيدها تقترح عليهم الآن أنا شايف ردود ماشية
+
+2
+00:00:08,880 --> 00:00:19,140
+الأسئلة
+
+3
+00:00:19,140 --> 00:00:26,680
+حول ترتيب الأمور بالنسبة للامتحان وشو أدرس وشو ما
+
+4
+00:00:26,680 --> 00:00:35,310
+أدرسش أجلوهااللي اتكلمنا كثيرًا عن مواضيع إنه أنت
+
+5
+00:00:35,310 --> 00:00:39,930
+هدفك يعني خلّي عينك صحيح أنت أحسن مشغول في العلمات
+
+6
+00:00:39,930 --> 00:00:44,570
+و بتسأل و بدك أحسن علامة و تنافس شديد و كل العالم
+
+7
+00:00:44,570 --> 00:00:50,710
+هيك حتى في جامعتنا و لا في أي مكان بس بالأخير يعني
+
+8
+00:00:50,710 --> 00:00:56,060
+الأهم إنك أنت تطلع فهمانإنك تطلع مستوعب للكلام
+
+9
+00:00:56,060 --> 00:01:03,000
+بحيث إنك تستطيع إنك يعني تتعامل في الحياة بعدين مع
+
+10
+00:01:03,000 --> 00:01:07,000
+هذه المعلومات فخلّينا من هذا مطوع أنا بسأل إذا حد
+
+11
+00:01:07,000 --> 00:01:14,300
+عنده أسئلة عن المادة العلمية مش داخل مش داخل،
+
+12
+00:01:14,300 --> 00:01:19,680
+مطلوب مش مطلوب على قدر طموحك، بدك تتعب حالك، بدك
+
+13
+00:01:19,680 --> 00:01:25,520
+ترتاحإيش اسمه؟ ريح حالك، مافي مشكلة فنرجع مرة
+
+14
+00:01:25,520 --> 00:01:30,680
+ثانية، الآن بتسألت أنا إيش تركيب البروتين فكذا
+
+15
+00:01:30,680 --> 00:01:37,100
+واحد حكالي كتبت بقرا اسمه Primary وفيه ناس كتبوا
+
+16
+00:01:37,100 --> 00:01:43,860
+Amino Acids وفيه ناس كتبوا Secondary وTertiary مش
+
+17
+00:01:43,860 --> 00:01:51,090
+حاطين يعني تفاصيل لهذا الأمرأنا أتمنى بس إنه الـ…
+
+18
+00:01:51,090 --> 00:01:58,910
+الـ… الـ… الـ… الـ«زوم»، الـ«تشات»، الـ«جروب تشات»
+
+19
+00:01:58,910 --> 00:02:03,670
+ولا الـ«هاي»، أنا بتبينش وإنه الـ«دسكتوب» تبعي كله
+
+20
+00:02:03,670 --> 00:02:09,590
+ظاهر عندكم في الصورة النقطة الأساسية إنه
+
+21
+00:02:09,590 --> 00:02:14,750
+الـ«بروتين» لما نشوفه في الحياة وفي الجسم بيقولوله
+
+22
+00:02:14,750 --> 00:02:19,410
+فيه أربع تركيباتأربع مستويات من التركيب، من
+
+23
+00:02:19,410 --> 00:02:26,190
+التعقيد الـ Primary Structure للبروتين هو عبارة عن
+
+24
+00:02:26,190 --> 00:02:31,550
+ترتيب الـ Amino Acids اللي بتشكل منها الـ
+
+25
+00:02:31,550 --> 00:02:37,070
+Polypeptide Chain اللي بتتشكل منها البروتين فلمّا
+
+26
+00:02:37,070 --> 00:02:42,470
+نتكلم إنه البروتين، يعني هندخل بعد شوية بالتفاصيل
+
+27
+00:02:42,980 --> 00:02:47,140
+بدّي الواحد يتخيله عشان يعرف يفهم أهمية الـ DNA
+
+28
+00:02:47,140 --> 00:02:54,040
+وليش ربنا حطوا فينا بهذه الطريقة فعنا بقول أربع
+
+29
+00:02:54,040 --> 00:03:03,160
+تركيبات لـ الـ اللي بده يرفع إيده الدكتور أحمد
+
+30
+00:03:03,160 --> 00:03:06,720
+معانا هو اللي بيخلي أنا بحب إنه حد يتكلم، بديش الـ
+
+31
+00:03:06,720 --> 00:03:11,560
+Chat هذا بودي إنه حد يتكلم حتى نفهم، يعني نشرح
+
+32
+00:03:11,560 --> 00:03:17,630
+الموضوعفلما نتكلم على تركيب الـ Protein نتكلم على
+
+33
+00:03:17,630 --> 00:03:24,030
+أربع خواص فيه أو أربع مستويات من التراكيب فيه لما
+
+34
+00:03:24,030 --> 00:03:28,070
+نقول بدا نصف الـ Primary Structure لأي Protein
+
+35
+00:03:28,070 --> 00:03:34,010
+بنقول إنه لازم نصف شو هو ترتيب الـ Amino Acids
+
+36
+00:03:34,010 --> 00:03:40,530
+اللي موجودة في الـ Polypeptide Chain فترتيب الـ
+
+37
+00:03:40,530 --> 00:03:44,330
+Amino Acidsهذا هو اللي يعتبر الـ Primary Structure
+
+38
+00:03:44,330 --> 00:03:51,750
+للـ Protein فإنها حوالي 20، 21 Amino Acid فبالتالي
+
+39
+00:03:51,750 --> 00:03:58,350
+لما نعد بواحد، اثنين، ثلاثة في الـ Polypeptide
+
+40
+00:03:58,350 --> 00:04:03,870
+Chainوبنقول إنه في أول أمينو أسد مثلًا «تريبتوفان»
+
+41
+00:04:03,870 --> 00:04:09,790
+«ألانين» مثلًا «أسبارتيت» كذا كذا الأمينو أسد اللي
+
+42
+00:04:09,790 --> 00:04:15,670
+بتعرفوها هدولة وصف الـ Primary Structure هو وصف
+
+43
+00:04:15,670 --> 00:04:20,110
+لإيش هي الأمينو أسد اللي بتكون منها البروتين الـ
+
+44
+00:04:20,110 --> 00:04:26,170
+Secondary Structure هو عبارة عن تركيب البروتين
+
+45
+00:04:26,170 --> 00:04:34,380
+الناتج عنالعلاقات والتفاعلات والتجاذبات بين الـ
+
+46
+00:04:34,380 --> 00:04:39,520
+Amino Acids جنب بعض فبينتج عن هذا التجاذب أنه فينا
+
+47
+00:04:39,520 --> 00:04:43,760
+نوعين من الـ Structures اللي بتكون المستوى الثاني
+
+48
+00:04:43,760 --> 00:04:48,000
+في تعقيد البروتين اللي هي بيسموه الـ Alpha Helix
+
+49
+00:04:48,000 --> 00:04:53,180
+أو الـ Beta Bleated Sheets يعني يا إما نتيجة
+
+50
+00:04:53,180 --> 00:04:58,070
+علاقاتالـ Side Chains تبعات الـ Amino Acids تبعات
+
+51
+00:04:58,070 --> 00:05:02,890
+الـ Primary Structure بيصير البروتين يلف على بعضه
+
+52
+00:05:02,890 --> 00:05:08,690
+إذا بتتخيلوا و بتشوفوا عندكم مثلا نفترض سليك
+
+53
+00:05:08,690 --> 00:05:13,730
+تليفون بين السماعة وجهاز التليفون بلولو بيصير
+
+54
+00:05:13,730 --> 00:05:19,610
+البروتين يتلولو بهذه الطريقة فوجود اللي بيسمونه
+
+55
+00:05:19,610 --> 00:05:24,170
+Alpha Helix أو Beta Bleated Sheets هدولة أنواع
+
+56
+00:05:24,500 --> 00:05:29,880
+أشكال التركيب الثانوي للبروتين يكون نتيجة علاقات
+
+57
+00:05:29,880 --> 00:05:33,420
+الـ Amino Acids مع بعض وبتكون الـ Amino Acids
+
+58
+00:05:33,420 --> 00:05:37,400
+هدولة جنب بعض لأنه حتى يلفب هذا الشكل القريب يكون
+
+59
+00:05:37,400 --> 00:05:42,680
+علاقات بين الـ Amino Acids مع بعض لما نكون نتكلم
+
+60
+00:05:42,680 --> 00:05:46,140
+عن الـ Tertiary Structure للبروتين زي الـ Globular
+
+61
+00:05:46,140 --> 00:05:53,130
+Structure إنه يكون على شكل مثلاًأبارعاً ثلاث إحبال
+
+62
+00:05:53,130 --> 00:05:59,030
+هيكلف على بعض أو على شكل كروي أو كده بيكون صار إنه
+
+63
+00:05:59,030 --> 00:06:06,750
+interaction between amino acid units on faraway
+
+64
+00:06:06,750 --> 00:06:13,090
+points on the amino acid polypeptide chain يعني
+
+65
+00:06:13,090 --> 00:06:18,250
+حتى يلف بهذا الشكل اللي يصير شكل كروي أو شكل بشكل
+
+66
+00:06:18,250 --> 00:06:20,530
+آخر ويكون نتيجة
+
+67
+00:06:23,460 --> 00:06:29,180
+التفاعلات بين الـ Amino Acids بعيدة عن بعضها في
+
+68
+00:06:29,180 --> 00:06:34,880
+الـ Primary Structure فهذه بتكون الـ Tertiary
+
+69
+00:06:34,880 --> 00:06:40,980
+Structure لأي بروتين ولمّا بعدين نتكلم على أن مثلا
+
+70
+00:06:40,980 --> 00:06:46,500
+الـ Hemoglobin بروتين عبارة عن حقيقة أربع
+
+71
+00:06:46,500 --> 00:06:52,950
+Polypeptidesأربع قطع، Two Alphas وTwo Betas كل
+
+72
+00:06:52,950 --> 00:06:56,910
+واحد منهم Alpha أو Beta هي عبارة عن بوليفيد بتاع
+
+73
+00:06:56,910 --> 00:07:03,190
+الـ Chain واحد معين وفي نصه فيه Hemomolecule الـ
+
+74
+00:07:03,190 --> 00:07:06,370
+Hemomolecule اللي فيه الحديد اللي بيمسك الـ Oxygen
+
+75
+00:07:06,370 --> 00:07:11,110
+فلما نتكلم على الـ Structure تبع الـ Total
+
+76
+00:07:11,110 --> 00:07:19,760
+Hemoglobin Protein بنقول إنه عبارة عن Fourوكل
+
+77
+00:07:19,760 --> 00:07:24,640
+واحدة منها Globular «هيمو» و «جلوبين» «جلوبين»
+
+78
+00:07:24,640 --> 00:07:30,500
+يعني كروي فالـ «هيمو» و «جلوبين» في أربع
+
+79
+00:07:30,500 --> 00:07:36,720
+Polypeptide Chains Two Alphas و Two Betas فالآن
+
+80
+00:07:36,720 --> 00:07:43,840
+يعني هذا كبروتين موجود في الجسم بتكون السر الأول
+
+81
+00:07:43,840 --> 00:07:47,570
+فيه في الـ Primary Structureاللي هو الـ Amino
+
+82
+00:07:47,570 --> 00:07:56,130
+Acids اللي بتكون منها وبعد ذلك، بتعقد الموضوع بالـ
+
+83
+00:07:56,130 --> 00:07:59,650
+Secondary Structure نتيجة الـ Alpha Helices والـ
+
+84
+00:07:59,650 --> 00:08:04,370
+Beta Pleated Sheets وبعدين بيصير أنها Tertiary
+
+85
+00:08:04,370 --> 00:08:10,070
+Structure نتيجة الحلقات
+
+86
+00:08:10,070 --> 00:08:15,480
+بين الـ Amino Acids البعد عن بعضوبعدين ندخل في الـ
+
+87
+00:08:15,480 --> 00:08:19,360
+Total Structure بالـ Quaternal Structure التركيب
+
+88
+00:08:19,360 --> 00:08:24,560
+الرباعي، الرابعي للبروتين فأي بروتين لما نيجي نصفه
+
+89
+00:08:24,560 --> 00:08:30,220
+نتكلم على أربع مستويات من الـ Structure فهو ياما
+
+90
+00:08:30,220 --> 00:08:35,960
+Primary وSecondary وTertiary وQuaternary الأمور
+
+91
+00:08:35,960 --> 00:08:38,340
+هيك واضحة، في حد عنده سؤال
+
+92
+00:08:41,490 --> 00:08:46,890
+دكتور أحمد، ماشي الحال، الشباب في حد .. ما .. ما
+
+93
+00:08:46,890 --> 00:08:51,050
+دكتور، مافي .. مافي .. مافي تحكي فيه جمانة رفعت
+
+94
+00:08:51,050 --> 00:08:56,350
+إيدها، تمام، بتخلي الجمانة تتكلم أو على أقل يعني
+
+95
+00:08:56,350 --> 00:09:02,190
+إثنين، ثلاثة تعطيهم سماح يتكلموا عشان نسمع يعني
+
+96
+00:09:02,190 --> 00:09:06,310
+يكونوا تفاعلوا بسرعة وشو اسمها؟ ان شاء الله، هنخلي
+
+97
+00:09:06,310 --> 00:09:13,390
+الدكتورة جمانة المستوى الرابع هو علاقاتإنه أكثر من
+
+98
+00:09:13,390 --> 00:09:19,670
+قطعة تدخل في تركيبه يعني، بدك تعتبر إنه زي «ليجو»…
+
+99
+00:09:19,670 --> 00:09:24,990
+ثوانية، جمانة، بس بعد إذنك، دكتور، اتفضل، كمل كأنه
+
+100
+00:09:24,990 --> 00:09:28,790
+زي قطعة «ليجو»، تعرفوها لعبة الأطفال اللي بتكون
+
+101
+00:09:28,790 --> 00:09:34,350
+أكثر من قطعة أحيانًا يكون أربع أو خمس أو أقل،
+
+102
+00:09:34,350 --> 00:09:41,430
+فنتين، تلاتة، individualPolypeptide chains يعني
+
+103
+00:09:41,430 --> 00:09:47,050
+عبارة عن تلاثة أو أربع قطع بروتينية بيشتركوا مع
+
+104
+00:09:47,050 --> 00:09:51,230
+بعض بيعطينا البروتين الأخير فزي الـ Hemoglobin الـ
+
+105
+00:09:51,230 --> 00:09:55,930
+Hemoglobin حقيقة هي أربع Polypeptide chains أربع
+
+106
+00:09:55,930 --> 00:10:01,310
+Globulins تنتين ألفة وتنتين بيتا كل واحد فيهم فيها
+
+107
+00:10:01,310 --> 00:10:05,710
+شغلة Hemoglobin راح ندخلها يعني Hem Group اللي هي
+
+108
+00:10:05,710 --> 00:10:16,710
+تمسك الـ Oxygen ف…ماشي أخت سهام آه الآن اللي سألة
+
+109
+00:10:16,710 --> 00:10:24,910
+سؤال رفعت إيدها تتكلم جمانة
+
+110
+00:10:24,910 --> 00:10:32,690
+أتكلم آه طيب الآن فالسر في كل التفاعلات البروتين
+
+111
+00:10:32,690 --> 00:10:39,540
+وخواص الحي المادة الحية هي حقيقةًفي ترتيب الـ
+
+112
+00:10:39,540 --> 00:10:46,700
+Amino Acids اللي موجودة في البروتين ماشي وحقيقة
+
+113
+00:10:46,700 --> 00:10:52,800
+يعني الواحد أنا بقول بده يعتبر هيك البروتين إبارة
+
+114
+00:10:52,800 --> 00:10:59,020
+عن إذا بدكم هيك عشان الواحد يستوعبها بقول يعتبر
+
+115
+00:10:59,020 --> 00:11:06,490
+إنها زي باللغة العربية نقور قصيدةالبردة، مدح
+
+116
+00:11:06,490 --> 00:11:12,690
+الرسول، قصيدة المعلقات، قصيدة إبارة عن مثلًا 150
+
+117
+00:11:12,690 --> 00:11:17,890
+بيت، بس بالأخير تركيب القصيدة في اللغة العربية
+
+118
+00:11:17,890 --> 00:11:23,830
+بالأخير هي أحرف، صحيح بتتكفكل من كلمات، بس الكلمات
+
+119
+00:11:23,830 --> 00:11:28,750
+بترجع للأخر للأحرف، وعنا في اللغة العربية 28 حرف،
+
+120
+00:11:30,460 --> 00:11:35,800
+البروتين لما نشوفه في واقع الحياة هو بيكون مثلًا
+
+121
+00:11:35,800 --> 00:11:43,680
+نعتبر قصيدة متكونة من كلمات نتيجة مكونة من أحرف
+
+122
+00:11:43,680 --> 00:11:50,460
+فبالأخير السر في القصيدة هي في ترتيب الأحرف تبعها
+
+123
+00:11:50,460 --> 00:12:02,330
+فالآن الـ DNA هو تمثيلمشفر بطريقة معينة حتى يضمن
+
+124
+00:12:02,330 --> 00:12:07,410
+كمادة وراثية للمعلومات اللي بالأخير بتعطينا الـ
+
+125
+00:12:07,410 --> 00:12:12,770
+Protein وبتعطينا القصيدة فهناك تشفير معين، رموز،
+
+126
+00:12:12,770 --> 00:12:19,930
+ترميز لكل حرف إنه شو اللي بيقابله من الـDNA حتى
+
+127
+00:12:19,930 --> 00:12:23,470
+يمكن عملية إنه نعمل
+
+128
+00:12:25,980 --> 00:12:32,820
+نعمل الـ «بروتينات» اللي احنا بحاجتها فالآن
+
+129
+00:12:32,820 --> 00:12:38,780
+لما ندرس المادة الوراثية اللي موجودة في الإنسان
+
+130
+00:12:38,780 --> 00:12:44,360
+وبتكون في كل خلايا الإنسان، الإنسان الواحد بشكل
+
+131
+00:12:44,360 --> 00:12:49,740
+رئيسي، بشكل يعني فيه هناك كأنه أكتر من نوع مادة
+
+132
+00:12:49,740 --> 00:12:53,340
+وراثية في جسم الواحد، راح نحكي عن دوار زي هيكبس
+
+133
+00:12:53,340 --> 00:12:56,640
+بشكل أساسي كل خلايا الإنسان لأنه بيبدأ من خلية
+
+134
+00:12:56,640 --> 00:13:00,780
+واحدة بيتم تلقيحها للبوايضة الملقحة بالحيوان
+
+135
+00:13:00,780 --> 00:13:05,120
+المنوي من الأب والأم، بالأخير الخلية الواحدة هذه
+
+136
+00:13:05,120 --> 00:13:09,440
+هي اللي بتنقسم كل الانقسامات المطلوبة وبنتج عنها
+
+137
+00:13:09,440 --> 00:13:14,180
+إنه بيصير اندي المظهر
+
+138
+00:13:14,180 --> 00:13:19,200
+اللي بنشوفه كذكر أو أمثة أو طفل أو كبير أو كده،
+
+139
+00:13:19,200 --> 00:13:27,930
+المادة الوراثية في الإنسانتقريبًا 97% موجودة في
+
+140
+00:13:27,930 --> 00:13:38,090
+النواة داخل الخليةفـ 97% من المادة الوراثية موجودة
+
+141
+00:13:38,090 --> 00:13:43,690
+في الـ Nuclear Chromosomes وهي حطيلكم صورة رسمية
+
+142
+00:13:43,690 --> 00:13:48,490
+أو صورة مش رسمية، يعني صورة الفحص اللي هو الـ
+
+143
+00:13:48,490 --> 00:13:52,530
+Karyotype اللي بنعمله وبكون في حالة الـ Cell
+
+144
+00:13:52,530 --> 00:13:56,910
+Division ممكن يكونوا مقابلين بعضه، بكون لهم ترتيب
+
+145
+00:13:56,910 --> 00:14:04,620
+معين وبنشوفههذا اللي هو بدرجة أساسية المادة
+
+146
+00:14:04,620 --> 00:14:09,040
+الوراثية تبع الإنسان في كل خلية حوالي 97%، يعني
+
+147
+00:14:09,040 --> 00:14:18,080
+تقريبًا 100% وبتكون لأنها لهم 23 زوج من
+
+148
+00:14:18,080 --> 00:14:22,460
+الـChromosomes فرح نقدر بعدين بتفصيل أكتر،
+
+149
+00:14:22,460 --> 00:14:30,970
+الـChromosomes هذه 22 زوجعبارة عن كروموزومات
+
+150
+00:14:30,970 --> 00:14:39,510
+أوتوزومال يعني جسمية اللي هي من 1 إلى 22 عبارة عن
+
+151
+00:14:39,510 --> 00:14:46,170
+تجميع للـ DNA بشكل معين وزوج أخر من الـ Six
+
+152
+00:14:46,170 --> 00:14:50,290
+chromosomes اللي هما الـ X والـ Y فهي اللي هي
+
+153
+00:14:50,290 --> 00:14:57,320
+التركيب تبعالـ Nuclear Chromosomes نسميهم المادة
+
+154
+00:14:57,320 --> 00:15:02,200
+الوراثية في النواة وتكون على شكل كروموزومات راح
+
+155
+00:15:02,200 --> 00:15:06,420
+ناخد تفصيلها وتركيبها وعلاقاتها بشكل أدق بعد شوية
+
+156
+00:15:06,420 --> 00:15:10,760
+تلاف بالمية طبعاً هدول الـ Nuclear Chromosomes
+
+157
+00:15:10,760 --> 00:15:14,680
+نصهم من الأب ونصهم من الأمالـ Mitochondrial
+
+158
+00:15:14,680 --> 00:15:20,220
+chromosomes بنسميهم قطعة صغيرة تبثل حوالي 3% من
+
+159
+00:15:20,220 --> 00:15:26,020
+الـ DNA في الخلايا الجسمانية بتكون من خلال الـ
+
+160
+00:15:26,020 --> 00:15:30,580
+mitochondria يعني الـ mitochondria اللي هي بتعرفوا
+
+161
+00:15:30,580 --> 00:15:34,640
+كلكم من المدارس إنها بنسميها أفران الطاقة في
+
+162
+00:15:34,640 --> 00:15:40,600
+الخليةبتكون هي المحل اللي بتتم فيها الـGlycolysis
+
+163
+00:15:40,600 --> 00:15:46,940
+والـRespiratory Chain والـCrip Cycle بحيث إنه يتم
+
+164
+00:15:46,940 --> 00:15:51,940
+هضم المواد زي الـGlucose بحيث يعطينا بالأخير ATP
+
+165
+00:15:51,940 --> 00:15:58,820
+وطاقة وبتكون الخلية بتتحرك من خلال الـATP اللي
+
+166
+00:15:58,820 --> 00:16:03,230
+بتحتاجه في عملية الطاقةفالـ Mitochondrial
+
+167
+00:16:03,230 --> 00:16:10,750
+chromosomes تمثل 3% من الـ DNA لاحظنا إن الـ
+
+168
+00:16:10,750 --> 00:16:15,370
+Proteins اللي هذا الـ DNA اللي موجود في الـ
+
+169
+00:16:15,370 --> 00:16:21,710
+Mitochondria مرتبط بالبروتينات اللي احنا بحاجتها
+
+170
+00:16:21,710 --> 00:16:27,570
+عشان نسوي الـ ATP عشان في الـ steps عشان نكوّن
+
+171
+00:16:27,570 --> 00:16:32,000
+المركبات الطاقة الـ ATPكل الأشياء اللي أنا عادة
+
+172
+00:16:32,000 --> 00:16:35,540
+بحتاجها أو غالبيتي الأشياء اللي أنا بحتاجها عشان
+
+173
+00:16:35,540 --> 00:16:40,080
+أطلع الـ ATP موجودة في الـ Mitochondrial DNA وهذه
+
+174
+00:16:40,080 --> 00:16:48,960
+تمثل 3% من الـ DNA بالنسبة
+
+175
+00:16:48,960 --> 00:16:56,940
+للـ ATP، آه بالنسبة لـ Mitochondrial Inheritance
+
+176
+00:16:56,940 --> 00:17:02,930
+للـ Mitochondrial DNAالوراثة تبعاتهم بتكون لأنه
+
+177
+00:17:02,930 --> 00:17:08,810
+الـ الـ «ميتوكندرية» بتنتقل من خلال الـ Boida فقط
+
+178
+00:17:08,810 --> 00:17:14,270
+الحيوان المنوي ما فيه «ميتوكندرية» فيه له أشياء
+
+179
+00:17:14,270 --> 00:17:20,090
+تراكيب ثانية بس مافي «ميتوكندرية» تشتغل في الـ
+
+180
+00:17:20,090 --> 00:17:25,110
+Fertilized egg فبالتالي الـ «ميتوكندرية» الـ DNA
+
+181
+00:17:25,110 --> 00:17:30,870
+انتقاله فقط عن طريق الأمعن طريق الأنثى ما في أي
+
+182
+00:17:30,870 --> 00:17:34,930
+انتقال من طريق الذكر زي الـ Nuclear Chromosomes
+
+183
+00:17:34,930 --> 00:17:39,370
+اللي فيها نص من الأب ونص من الأم فالـ
+
+184
+00:17:39,370 --> 00:17:44,590
+Mitochondrial DNA موجود في بعض الأمراض، راح ناخد
+
+185
+00:17:44,590 --> 00:17:48,670
+بعض الأمثل عليها بتكون نتيجة Mitochondrial
+
+186
+00:17:48,670 --> 00:17:53,410
+Chromosome Anomalies وبتكون فيها مشاكل لهذا الجرم
+
+187
+00:17:53,410 --> 00:17:56,390
+فالآن
+
+188
+00:17:57,320 --> 00:18:05,060
+يعني حتى إن شفّر الأحرف اللي هي تبعت قصيدة الـ
+
+189
+00:18:05,060 --> 00:18:12,040
+Protein ماشي مثلا، يعني زي إذا بدأت تعتبر مثلا
+
+190
+00:18:12,040 --> 00:18:16,080
+القفة نفكي من ذكرا حبيبا ومنزلي بسقط اللي هو بين
+
+191
+00:18:16,080 --> 00:18:22,320
+الدخولي فحملي عند معلقة تمرو القيس القاف في قفة
+
+192
+00:18:22,320 --> 00:18:30,160
+ماشي هي Amino Acid بسحتى أشفره بالـ DNA بدي أكون
+
+193
+00:18:30,160 --> 00:18:36,780
+عندي ثلاثة من الـ Nucleotides تبع الـ DNA وبصير
+
+194
+00:18:36,780 --> 00:18:44,180
+أنا أقرأ الـ DNA بهذا الشكل فالقراءته
+
+195
+00:18:44,180 --> 00:18:49,120
+بنسميها اللي هي الـ Human Genome Sequence اللي هو
+
+196
+00:18:49,120 --> 00:18:53,280
+إنه أنا أقرأ شو الأحرف أو بلاش أسميه أحرف شو
+
+197
+00:18:53,280 --> 00:19:01,030
+التشفير تبع الأحرف تبعالبروتين اللي يعني بيكون
+
+198
+00:19:01,030 --> 00:19:05,390
+بيمثل البروتين اللي هو بيمثل الكائن الحي اللي هو
+
+199
+00:19:05,390 --> 00:19:11,930
+الإنسان فأرجو أن تكون تركيب يعني أو كيف تجهيز
+
+200
+00:19:11,930 --> 00:19:17,510
+المادة اللازمة لإنتاج البروتين اللي هم اللي بالأخر
+
+201
+00:19:17,510 --> 00:19:21,140
+بنسميهم فيه Nuclear Chromosomesبيكونوا بطريقة
+
+202
+00:19:21,140 --> 00:19:25,500
+معينة نورثهم من الأب والأم جزء قليل من الـ
+
+203
+00:19:25,500 --> 00:19:28,580
+Mitochondrial chromosomes ونتخذهم من الأم فقط
+
+204
+00:19:28,580 --> 00:19:34,840
+وبتكون حوالي 3% وهسة راح ندخل أكتر تفاصيل كيف هذا
+
+205
+00:19:34,840 --> 00:19:41,560
+الأمر بتتم في أسئلة؟ في إشي مش واضح؟ في حد عنده
+
+206
+00:19:41,560 --> 00:19:42,160
+سؤال؟
+
+207
+00:19:48,450 --> 00:19:56,390
+ماشي اسأله إذا الواحد بيظل يعني بتظلكم ساكتين مش
+
+208
+00:19:56,390 --> 00:20:01,250
+عارف نعرف الآن
+
+209
+00:20:01,250 --> 00:20:12,630
+بالنسبة لتركيب الـ DNA هو من أهم الأشياءومن يعني
+
+210
+00:20:12,630 --> 00:20:17,490
+لما اكتشفوه وافتشفوا كيف بالداخل دكتور في سؤال
+
+211
+00:20:17,490 --> 00:20:24,150
+بيقول يعني في نور ما فهم شو دخل الـ «ميتوكندرية»
+
+212
+00:20:24,150 --> 00:20:31,630
+بالبروتين بالأم أعتقد غصده بالـ «ماتر» يعني ده
+
+213
+00:20:31,630 --> 00:20:38,350
+بيطهم وخليه يسأل الـ «ميتوكندرية»
+
+214
+00:20:39,680 --> 00:20:44,860
+انتقالها عبارة عن إنها موجودة في البويضة طبعاً
+
+215
+00:20:44,860 --> 00:20:50,100
+يعني هاي … يعني الـMitochondria هي فرن الطاقة اللي
+
+216
+00:20:50,100 --> 00:20:55,460
+لما تيجي تاخدها كتدريب يعني أنتوا بتخلونا نشرح مش
+
+217
+00:20:55,460 --> 00:20:59,120
+غلط الواحد يتعرف على أشياء تانية الـMitochondria
+
+218
+00:20:59,120 --> 00:21:06,870
+في الخلية تعتبر أحياناً زي جسم غريبزي بكتيريا
+
+219
+00:21:06,870 --> 00:21:12,890
+صغيرة حقيقةً هي بكتيريا صغيرة موجودة جوا الخلية
+
+220
+00:21:12,890 --> 00:21:18,350
+وبتكون عشان يعني هيكذا بتشوفوا بالنسبة لصورتها الـ
+
+221
+00:21:18,350 --> 00:21:22,270
+Cell Membrane تبع الخلية واحد بس الـ Mitochondria
+
+222
+00:21:22,270 --> 00:21:26,130
+is الـ Wall تبع الـ Mitochondria Double يعني
+
+223
+00:21:26,130 --> 00:21:30,770
+بيعتبروا أنه في إشي جوا إشي فالـ Mitochondria
+
+224
+00:21:30,770 --> 00:21:40,750
+جواها في DNA البروتيناتاللي بتنتج عن تشغيل وتفعيل
+
+225
+00:21:40,750 --> 00:21:46,110
+الـ «DNA» بحيث يعطينا بروتين هو راح يكون إنه
+
+226
+00:21:46,110 --> 00:21:50,970
+يعطينا البروتينات اللازمة لعملية إنتاج الطاقة
+
+227
+00:21:50,970 --> 00:21:55,030
+وإنتاج الـ «DNA» ما هو الـ «ميتوكندرية» وظيفتها
+
+228
+00:21:55,030 --> 00:22:01,070
+إنها تطلع الـ ATP اللي التفاعلات الكيموية والحركة
+
+229
+00:22:01,070 --> 00:22:07,020
+في الخلية وغيرها، بدها طاقة، فبتكون من الـالـ ATP
+
+230
+00:22:07,020 --> 00:22:11,280
+اللي بنتج من الميتوكندرية نتيجة تفاعلات تحتاج
+
+231
+00:22:11,280 --> 00:22:15,700
+بروتينات الـ DNA لهذه البروتينات في الميتوكندرية
+
+232
+00:22:15,700 --> 00:22:21,800
+وهذا يتم نقله من خلال البويضة فقط يعني الـ sperm
+
+233
+00:22:21,800 --> 00:22:26,420
+من الأب ماهي له دخلة عشان هيك لما تدرس الـ
+
+234
+00:22:26,420 --> 00:22:29,180
+mitochondrial inheritance والـ mitochondrial
+
+235
+00:22:29,180 --> 00:22:36,450
+diseases بتكون انتقالها عن طريق الأمة واضح؟في لسة
+
+236
+00:22:36,450 --> 00:22:40,790
+سؤال، اسألني أنت يا أحمد إذا في حد عنده شيء مش
+
+237
+00:22:40,790 --> 00:22:45,470
+واضح، أه
+
+238
+00:22:45,470 --> 00:22:49,730
+فيه بيعلق يعني، بيسأل، بيعقب على السؤال، بيقول
+
+239
+00:22:49,730 --> 00:22:55,530
+يعني كل الموضوع إنه العمليات بتحتاج ATP، طبعاً كل
+
+240
+00:22:55,530 --> 00:23:00,870
+كثير من عمليات الكيموية والحركية وغيرها، فللخلايا
+
+241
+00:23:00,870 --> 00:23:06,060
+بدها طاقة،الباقة بتيجي من الـ ATP الـ ATP بنتجه
+
+242
+00:23:06,060 --> 00:23:11,840
+تفاعلات كيموية بدها أنزيمات وبروتينات نتيجة يعني
+
+243
+00:23:11,840 --> 00:23:16,780
+بتكون في الـ mitochondria وهدولة الـ الـ DNA
+
+244
+00:23:16,780 --> 00:23:21,700
+المسؤول عنها موجود جوا الـ mitochondria بيمثل 3%
+
+245
+00:23:21,700 --> 00:23:27,680
+من الـ DNA تبع الخلية وهذا يتم نقله من خلال الأم
+
+246
+00:23:27,680 --> 00:23:34,000
+فقط الأب ما إله دخلفاهم عليك كيف؟ وهذه حتى إذا
+
+247
+00:23:34,000 --> 00:23:38,640
+واحد قرأ دراسة قبل مدة إنه بيرجعوا البشر كلهم لـ7
+
+248
+00:23:38,640 --> 00:23:44,740
+أمهات لأنه فيه variation بشكل معين وإنه بتكون
+
+249
+00:23:44,740 --> 00:23:48,540
+لدراسة الـMitochondrial DNA والـMitochondrial
+
+250
+00:23:48,540 --> 00:23:52,940
+Chromosomes فهدولة موجودين وهدولة أحيانًا بسببوا
+
+251
+00:23:52,940 --> 00:23:58,100
+أمراض حتى لو ما كان في الـNucleus اللي هي الجزء
+
+252
+00:23:58,100 --> 00:24:03,100
+الأكبر من الـDNA فيهابس دايماً لما نقول gene هو
+
+253
+00:24:03,100 --> 00:24:09,040
+شيء بالمادة الورافية يعني يمكن توريثه ويمكن اللي
+
+254
+00:24:09,040 --> 00:24:14,280
+أخدناه فضية انقسامه وبالتالي بتعطينا بدل نسخة
+
+255
+00:24:14,280 --> 00:24:20,940
+واحدة نسختين ويتكاثر بشكل يحفظ المادة الورافية
+
+256
+00:24:20,940 --> 00:24:24,940
+اللي بتعطينا شكل الـ protein اللي راح يطلع بالأخير
+
+257
+00:24:24,940 --> 00:24:26,900
+واضح؟
+
+258
+00:24:32,000 --> 00:24:37,120
+هي حد عنده سؤال؟
+
+259
+00:24:37,120 --> 00:24:43,260
+طيب التركيب،
+
+260
+00:24:43,260 --> 00:24:50,860
+خلّينا نرجع لهذه شوية تركيب الـ DNA وهذا في سنة
+
+261
+00:24:50,860 --> 00:24:56,240
+الـ 1954 وبعدين أخذوا عليه جهازة Nobel عالمين
+
+262
+00:24:56,240 --> 00:25:02,130
+اسمهم Watson وCreekأثبتوا أو من خلال دراستهم
+
+263
+00:25:02,130 --> 00:25:07,990
+لتقنية الـ X-Ray Crystallography أيشي طريقة بندرس
+
+264
+00:25:07,990 --> 00:25:15,650
+فيها المركبات وتركيبة كيماوية أنه بنشع عليها X
+
+265
+00:25:15,650 --> 00:25:21,210
+-Rays وبنشوف في الفيلم كيف تركيبه وكذا أثبتوا أن
+
+266
+00:25:21,210 --> 00:25:28,080
+الـ DNA عبارة عن سلم حلزوني بهذا الشكل السلمالعادي
+
+267
+00:25:28,080 --> 00:25:34,840
+بتلاقي يعني قصتين طوال وبينهم اقصار الـ «steps»
+
+268
+00:25:34,840 --> 00:25:41,620
+اللي بتطلع عليهم فبالنسبة للـ «DNA» السلم هذا
+
+269
+00:25:41,620 --> 00:25:47,820
+لولبي يعني بيقعد يلف على بعضه فإذا أنت بتشوفه
+
+270
+00:25:47,820 --> 00:25:54,380
+تركيبيعني هذا هي شكله اللي هو بنسميه سلة ملولة
+
+271
+00:25:54,380 --> 00:26:01,780
+بالـ Double Helix Ladder يعني هذا شكله الدورة
+
+272
+00:26:01,780 --> 00:26:07,100
+الكاملة منه زي هذا الشكل أربعة و تلاتين Angstrom
+
+273
+00:26:07,100 --> 00:26:14,480
+اللي هو كـ Size وبين عشر سطبات
+
+274
+00:26:14,480 --> 00:26:20,640
+أو عشرالمكان اللي بتحط إجرك عليه في السلم، العتبات
+
+275
+00:26:20,640 --> 00:26:25,120
+تبعته اللي هي طولها بين الواحد والثانية، ثلاث
+
+276
+00:26:25,120 --> 00:26:28,700
+وأربعة من عشرة أنجستروك لما تيجي تاخد تركيب هذا
+
+277
+00:26:28,700 --> 00:26:35,120
+الأمر بتلاقي أول شيء أنه في اللي هي الخضرة الفاتحة
+
+278
+00:26:35,120 --> 00:26:43,990
+هذه اللي هو رايبو رايبوزو اللي هوالريبوز اللي هو
+
+279
+00:26:43,990 --> 00:26:50,850
+السكر الخماسي اللي هو هذا الريبوز آسف بالـ DNA
+
+280
+00:26:50,850 --> 00:26:55,870
+ديوكسي ريبوز لأن الـ RNA هو اللي فيه الريبوز بس
+
+281
+00:26:55,870 --> 00:27:01,130
+الريبوز هو سكر خماسي
+
+282
+00:27:01,130 --> 00:27:06,010
+يعني فيه خمس درّات كربون وفيه من طرف تاني فوسفات
+
+283
+00:27:09,390 --> 00:27:15,730
+الخشب الطويلة تبعت السلم عبارة عن هيك فوسفات دوكسي
+
+284
+00:27:15,730 --> 00:27:19,090
+رايبوس، فوسفات دوكسي رايبوس، فوسفات دوكسي رايبوس
+
+285
+00:27:19,090 --> 00:27:28,310
+بالترتيب هذا، هذا أشي ثابت، ماشي، بالنص بينهم فيه
+
+286
+00:27:28,310 --> 00:27:34,100
+قواعد نيتروجينية، nitrogen basesففيه عندنا الـ…
+
+287
+00:27:34,100 --> 00:27:40,860
+الـ… يعني هنا هذه التركيب الـ… الـ… أقولها، هذه
+
+288
+00:27:40,860 --> 00:27:46,020
+مجموعة الفوسفات وهذه الـRibose وهنا بشبك فيه
+
+289
+00:27:46,020 --> 00:27:50,280
+الـBase رقم واحد بعدين بيجي فوسفات، بيجي Ribose،
+
+290
+00:27:50,280 --> 00:27:54,160
+بيجي الـBase رقم اثنين فوسفات، Ribose، الـBase رقم
+
+291
+00:27:54,160 --> 00:28:01,830
+ثلاثة تيجي بهذا الترتيب الـ… بالنسبة لـ…لما ناخد،
+
+292
+00:28:01,830 --> 00:28:10,810
+نقيص على تركيبة الـ «ريبوز» إنه إذا بتاخدوا
+
+293
+00:28:10,810 --> 00:28:17,310
+بالكيميا الحيوية، بتكون إنك أنت بتقدرالشكل الريبوز
+
+294
+00:28:17,310 --> 00:28:26,690
+هذا جاي خماسي بس بنحسب بما أنه هنا الأكسجينة الـ
+
+295
+00:28:26,690 --> 00:28:31,870
+Deoxyribose بيكون الريبوز فيه أكتر من هيك بس
+
+296
+00:28:31,870 --> 00:28:37,730
+الأكسجينة بنحسب عليها فبتقدروا أن هذا الكربون
+
+297
+00:28:37,730 --> 00:28:41,210
+الأولى وهذه الكربون الثانية وهذه الثالثة وهذه
+
+298
+00:28:41,210 --> 00:28:47,680
+الرابعة وهذه الخمسة فالـ Phosphateبتشبك على من جهة
+
+299
+00:28:47,680 --> 00:28:54,020
+في رقم خمسة ومن جهة في رقم ثلاثة فلما نيجي نتكلم
+
+300
+00:28:54,020 --> 00:29:02,780
+كيف شكل ترتيب العصاطين القشبيات بكونوا عكس بعض
+
+301
+00:29:02,780 --> 00:29:09,340
+بحيث إنه في عصاية من جهة تبدأ بالـ ribosomes تشبك
+
+302
+00:29:09,340 --> 00:29:15,820
+عليها من جهة رقم خمسة بيسموها الـ5'Nبيظل ماشي لحد
+
+303
+00:29:15,820 --> 00:29:20,140
+الـ Third Prime إنه بالنسبة للـ Ladder الثاني
+
+304
+00:29:20,140 --> 00:29:24,940
+بيكون ماشي بالعكس بدأ من تحت بالـ Five وبيطلع من
+
+305
+00:29:24,940 --> 00:29:29,360
+فوق على ال Third أو على ال Three Prime يعني هدولة
+
+306
+00:29:29,360 --> 00:29:36,620
+في تفاصيل التركيب الكيماوي للـ DNA هدولة العصاطين
+
+307
+00:29:36,620 --> 00:29:41,960
+أو الخشبتين الطوال بيلفوا على بعض بهذا الشكل
+
+308
+00:29:42,540 --> 00:29:51,040
+وبكونوا يعني بكونوا ماشيين يعني اتجاههم من خمس
+
+309
+00:29:51,040 --> 00:29:55,540
+لثلاث ومن خمس لثلاث حتى يظبط ان يكون هذا الشكل
+
+310
+00:29:55,540 --> 00:30:00,140
+بهذه الطريقة واللي بمسكهم بالنص اللي هي العطبات
+
+311
+00:30:00,140 --> 00:30:06,730
+اللي بقدر أجر عليها وانا طالع بكون في عنديزوج من
+
+312
+00:30:06,730 --> 00:30:12,470
+الأحماض الـ Amino الـ Nitrogenous Bases القواعد
+
+313
+00:30:12,470 --> 00:30:17,670
+النيتروجينية فالقواعد النيتروجينية بنقسمهم إشي
+
+314
+00:30:17,670 --> 00:30:21,790
+اسمه Purines قواعد نيتروجينية هي فيها نيتروجين
+
+315
+00:30:21,790 --> 00:30:26,570
+وCarbon بهذا الشكل فالـPurines اللي هي الأكبر فيها
+
+316
+00:30:26,570 --> 00:30:30,650
+Two Rings Like This منها الأدينين ومنها الإيجوانين
+
+317
+00:30:30,650 --> 00:30:35,650
+وهذا المفروض أخد Two بالـBiochemistryفالـ Purines
+
+318
+00:30:35,650 --> 00:30:39,910
+اللي هم الأكبر والـ Pyrimidines اللي هم الأصغر
+
+319
+00:30:39,910 --> 00:30:45,930
+اللي هم الثيامين والـ Cytosine فالـ DNA بيكون هدول
+
+320
+00:30:45,930 --> 00:30:51,570
+الأربع المشتركين كل step نحط أجرنا عليها وإحنا
+
+321
+00:30:51,570 --> 00:30:57,510
+طالعين على السلم بتكون واحد Purine مع واحد
+
+322
+00:30:57,510 --> 00:31:02,490
+Pyrimidine بس الأدنين مع الثيامين والجوانين مع الـ
+
+323
+00:31:02,490 --> 00:31:09,380
+Cytosine يعنيدايماً على الجهة هذه، اندي واحدة من
+
+324
+00:31:09,380 --> 00:31:12,860
+أربع خيارات ممكن تكون عندي ممكن تكون Guanine،
+
+325
+00:31:12,860 --> 00:31:18,960
+Cytosine، Adenosine، Adenine أو Guanine مرة ثانية،
+
+326
+00:31:18,960 --> 00:31:24,240
+فكل واحد من هذا لازم يشبك مع واحد من النوع التاني،
+
+327
+00:31:24,240 --> 00:31:28,660
+فهنا كانت Guanine شبكة high مع Cytosine، هنا
+
+328
+00:31:28,660 --> 00:31:34,090
+Cytosine مع Guanine، هنا Adenine مع الثامن،فدول
+
+329
+00:31:34,090 --> 00:31:37,070
+الأدنين والثامين زي ما انتوا شايفين بيكون two
+
+330
+00:31:37,070 --> 00:31:45,180
+bonds بين الإيجوانين والسايتزين تلاتي bondsFossile
+
+331
+00:31:45,180 --> 00:31:49,380
+bond يعني Hydrogen bond شوية نوع عامة ضعيف كثير مش
+
+332
+00:31:49,380 --> 00:31:53,660
+قوية كثير، يعني مش Covalent bond مش Ionic bond،
+
+333
+00:31:53,660 --> 00:31:58,460
+يعني إشي قوي كثير، لأ عبارة عن شيء ممكن أنا أفكه و
+
+334
+00:31:58,460 --> 00:32:04,520
+أركبه، بس فيه قوة وانتصاق وممكن يشبك مع بعض،
+
+335
+00:32:04,520 --> 00:32:12,300
+فبالنسبة لتركيب الـ DNA، هذا تركيبه، بالنسبة
+
+336
+00:32:12,300 --> 00:32:21,740
+لترتيباللي بيعطينا الشفرة عشان نعرف نطلع البروتين
+
+337
+00:32:21,740 --> 00:32:28,020
+اللي كويس هو ترتيب هذه الـ… الـNitrogenous Bases
+
+338
+00:32:28,020 --> 00:32:32,280
+هذا الترتيب هو اللي بالأخير راح يكون مسئول عن
+
+339
+00:32:32,280 --> 00:32:38,280
+البروتين اللي راح يطلع فطبعاً
+
+340
+00:32:38,280 --> 00:32:43,690
+يعني وجود هذا التركيب، سبحان الله يعنيعجيب، ويعني
+
+341
+00:32:43,690 --> 00:32:47,250
+فعلاً اللي اكتشفوا وفسروا الظواهر اللي إحنا
+
+342
+00:32:47,250 --> 00:32:51,950
+بنشوفها كيف الخلية بتنقسم، كيف ممكن المادة
+
+343
+00:32:51,950 --> 00:32:56,470
+الوراثية تورّف كم ممكن أن يحافظ عليها، كيف يتم
+
+344
+00:32:56,470 --> 00:33:02,570
+نسخها، كيف يتم التعامل معها أخد جائزة نوبل، وهذه
+
+345
+00:33:02,570 --> 00:33:06,030
+يعني بتفسر كثير من الظواهر وهذا الآن اللي إحنا
+
+346
+00:33:06,030 --> 00:33:10,790
+بنعتبره في علم الوراثة في حد عنده سؤال، في إيش مش
+
+347
+00:33:10,790 --> 00:33:11,230
+واضح
+
+348
+00:33:17,730 --> 00:33:23,910
+دكتور أحمد غيره أو أي حد عنده أي سؤال؟ لا دكتور
+
+349
+00:33:23,910 --> 00:33:28,030
+اتوكل على الله غالبا مافي أسئلة في الشاشة طيب،
+
+350
+00:33:28,030 --> 00:33:34,550
+الآن دكتور في سؤال من دكتورة سيهام تسأل شو اسم
+
+351
+00:33:34,550 --> 00:33:40,630
+الأشعة؟ هذا تقنية أو تقنية في دراسة اللي اشتغل
+
+352
+00:33:40,630 --> 00:33:50,030
+عليها واتسون وكريج أه أه أه بحكيلكمن الطرق اللي
+
+353
+00:33:50,030 --> 00:33:55,350
+قديمة في دراسة التركيب الكيماوي للمركبات اللي هي
+
+354
+00:33:55,350 --> 00:34:04,210
+إنه بتخلي المادة على شكل بلوراتشايف علي؟ يعني أنت
+
+355
+00:34:04,210 --> 00:34:13,390
+بتجيب سواء DNA، سخرة، بروتين، دهول، أي شيء بتبردها
+
+356
+00:34:13,390 --> 00:34:19,890
+بحيث تصبح على شكل بلورة يعني إنها ترتب حالها بشكل
+
+357
+00:34:19,890 --> 00:34:23,190
+منتظم،
+
+358
+00:34:23,190 --> 00:34:28,830
+مش يعني فالته فلما ترتبها بشكل منتظم، بعدين
+
+359
+00:34:28,830 --> 00:34:36,250
+بتعرضها لأشعة Xلما نتيجي على زي أشعة العظام لما
+
+360
+00:34:36,250 --> 00:34:41,670
+نتعرضها لهذه الأشعة تتفرج الجهة الثانية على كيف
+
+361
+00:34:41,670 --> 00:34:47,750
+صورتها من خلال الأشعة على فيلم الأشعة بتقول تقدر
+
+362
+00:34:47,750 --> 00:34:52,010
+تستنتج كيف كان تركيبها فهذه التقنية اسمها X-Ray
+
+363
+00:34:52,010 --> 00:34:58,280
+Crystallography يعني Crystal بلورةوGeography يعني
+
+364
+00:34:58,280 --> 00:35:04,240
+شو اسمه؟ عبارة عن تصوير التصوير البلوري عن طريق
+
+365
+00:35:04,240 --> 00:35:09,880
+أشعة X هيك اللي كان يستخدموه فمن خلالها الأبعاد
+
+366
+00:35:09,880 --> 00:35:14,400
+اللي هي بنحكيها الـ «أنغستروم» اللي هي إذا تتفرج
+
+367
+00:35:14,400 --> 00:35:18,940
+هنا إنه عشرين أنغستروم وهي أربعة وثلاثين أنغستروم
+
+368
+00:35:18,940 --> 00:35:24,680
+وبين واحدة واحدة 3.4 وفي عشرة في كل لولب، هي من
+
+369
+00:35:24,680 --> 00:35:29,570
+خلالطريقة الدراسة هذه استطعنا نقرأ شو تركيبها
+
+370
+00:35:29,570 --> 00:35:34,910
+واضحة؟ فهي X-Ray Crystography يعني التصوير البلوري
+
+371
+00:35:34,910 --> 00:35:42,730
+بأشعة X هذه التقنية وهكي عرفوا تركيب الـDNA في
+
+372
+00:35:42,730 --> 00:35:52,930
+أسئلة ثانية؟ إيش يا باي سلان؟ باي لسان؟ إيش دكتور
+
+373
+00:35:52,930 --> 00:35:57,900
+أحمد؟ خليها تتكلم أوأسمع منكم إذا في أسئلة ثانية
+
+374
+00:35:57,900 --> 00:36:04,460
+في
+
+375
+00:36:04,460 --> 00:36:11,100
+أسئلة؟ اتفضل يا «بالي لسان» إذا كان في سؤال خلاص،
+
+376
+00:36:11,100 --> 00:36:17,000
+تمام، بالخطأ، مش مشكلة مش مشكلة بالنسبة ل… الآن
+
+377
+00:36:17,000 --> 00:36:23,440
+يعني حكينا يعني ليش الأمر ربنا حطه فينا بهذا الشكل
+
+378
+00:36:23,440 --> 00:36:31,790
+بالنسبة للـDNAإن انت بتقدر تستنسخ بشكل دقيق وثابت
+
+379
+00:36:31,790 --> 00:36:41,590
+ومحدد تماماً قضية إنه نسخة واحدة من الـ DNA زي
+
+380
+00:36:41,590 --> 00:36:46,150
+القطعة اللي فوق عندما تحتاج أو في مرحلة معينة
+
+381
+00:36:46,150 --> 00:36:53,790
+بتفرط الخشبتين تبع السلة من اللولة بعن بعضوتقدر
+
+382
+00:36:53,790 --> 00:37:02,030
+تعيد بناءهم كامل مكمّل زي ما كان في الأساس من خلال
+
+383
+00:37:02,030 --> 00:37:07,750
+الاحتفاظ بنفس العلاقات بين القواعد النيتروجينية
+
+384
+00:37:07,750 --> 00:37:16,190
+الـA قبالها الـT والـC قبالها الـG وكل يعني
+
+385
+00:37:16,190 --> 00:37:26,770
+backbone أو كل خط من هدولة ترتيبالـ… الأحماض أو
+
+386
+00:37:26,770 --> 00:37:33,010
+الترتيب القواعد النيتروجيني هنا يحفظ تمامًا والـ…
+
+387
+00:37:33,010 --> 00:37:39,230
+والإيش الناقص يتمم بالترتيب كامل بحيث بنسبة عالية
+
+388
+00:37:39,230 --> 00:37:46,990
+جدًا جدًا بتم استنساح الـDNA بحيث يكون بشكل كامل،
+
+389
+00:37:46,990 --> 00:37:56,070
+بشكل متطابق تمامًافيعني هذه سر في قضية حفظ
+
+390
+00:37:56,070 --> 00:38:02,750
+المعلومات وحفظ الشفرة الوراثية لكل واحد مننا من
+
+391
+00:38:02,750 --> 00:38:08,430
+خلال أنه لما تحتاج تقسم وتضاعف من المادة الوراثية
+
+392
+00:38:08,430 --> 00:38:14,220
+بتقدر تضاعفها وتكون تماما مثل الأبمثل الأصل، يعني
+
+393
+00:38:14,220 --> 00:38:17,780
+مثل ما كانت سابقًا فبدل ما يكون عندك نسقة واحدة
+
+394
+00:38:17,780 --> 00:38:27,140
+بتصير عندك نسقتين تمامًا زي بعض، فيها أسئلة واضحة؟
+
+395
+00:38:27,140 --> 00:38:36,840
+الآن اللي لما إذا بتتخيلوا طبعًا عدد القواعد
+
+396
+00:38:36,840 --> 00:38:41,080
+النيتروجينية هدولة اللي هي بدنا نسميهم الأحرف في
+
+397
+00:38:41,080 --> 00:38:46,240
+الـDNAتقريبًا في الخلية الوحدة، في جسم الإنسان كله
+
+398
+00:38:46,240 --> 00:38:53,000
+هيك مع بعضه، ثلاث بلايين حرف، ثلاث بلايين
+
+399
+00:38:53,000 --> 00:38:58,580
+نيكليوتايد، طبعًا هذا أدد يعني ما واحد ييجي يتخيله
+
+400
+00:38:58,580 --> 00:39:03,320
+أدد كبير كثير، أنتوا آخر، أنتوا معاكم، اللي ورا
+
+401
+00:39:03,320 --> 00:39:10,350
+آخر جزء من هنا واضح ولا صورتنا جاي عليها؟أنت بتشوف
+
+402
+00:39:10,350 --> 00:39:15,290
+نفسك أنه بتطلع على الـscreen تبعي ولا ..؟ صح، صح،
+
+403
+00:39:15,290 --> 00:39:20,070
+لأ يا دكتور، واضحة بالنسبة للكل، يعني غالبا ما
+
+404
+00:39:20,070 --> 00:39:25,170
+بتكون نفس الـscreen الموجود عندنا طيب، تمام، لما
+
+405
+00:39:25,170 --> 00:39:33,840
+نيجي نتكلم على أنه عبارة عن nucleotidesماشي
+
+406
+00:39:33,840 --> 00:39:39,600
+تقريبًا هي ثلاث بلايين يعني ثلاثة في عشرة أس تسعة
+
+407
+00:39:39,600 --> 00:39:44,600
+لما تيجيوا تتخيلوا إذا أنتموا بتتذكروا أيام زمان
+
+408
+00:39:44,600 --> 00:39:51,820
+يمكن ماحدش منكم لحق هذا الموضوع كان زمان يكون
+
+409
+00:39:51,820 --> 00:39:58,740
+عندنا بيسموه اللي هو دليل الهاتف دليل الهاتف في أي
+
+410
+00:39:58,740 --> 00:40:05,290
+منطقة في العالمكان يبقى كتاب هيك سميك كثير ويكون
+
+411
+00:40:05,290 --> 00:40:10,070
+الخط صغير ويحطوا أسماء الناس ورقام تليفوناتهم
+
+412
+00:40:10,070 --> 00:40:13,650
+الأرضية يعني قبل التقنية الحالية والأشياء الآن
+
+413
+00:40:13,650 --> 00:40:21,830
+فدليل الهاتف يعني بيكون الخط صغير والصفحة فيها
+
+414
+00:40:21,830 --> 00:40:27,550
+مثلا تقريبًا خمس كولوك يعني خمس أعمدة من المادة
+
+415
+00:40:27,550 --> 00:40:33,870
+والورق خفيف كثيرفقدروا إذا انت بدك تكتب المادة
+
+416
+00:40:33,870 --> 00:40:37,690
+الوراثية تبع إنسان اللي هي موجودة الـ 9 ملايين
+
+417
+00:40:37,690 --> 00:40:43,740
+نيكليوتايد هذه فانت بتحتاج تقريبًامالة إنك تصفق
+
+418
+00:40:43,740 --> 00:40:48,400
+بعض من دلائل الهاتف ما هو بارتفاع اللي هي الـ
+
+419
+00:40:48,400 --> 00:40:53,300
+Empire State Building اللي هي كانت لحظة كبيرة يعني
+
+420
+00:40:53,300 --> 00:40:57,400
+أعلى برج في العالم وأعلى إشي يعني الآن بدك تقول
+
+421
+00:40:57,400 --> 00:41:02,180
+تقريبًا أقل شوية من برج خليفة في دبي ولا كده ولا
+
+422
+00:41:02,180 --> 00:41:09,110
+هيك فيعني هناك 9 بلايين Nucleotideاللي هي
+
+423
+00:41:09,110 --> 00:41:13,570
+الـNucleotide هو الإسم على القطعة المشتركة من
+
+424
+00:41:13,570 --> 00:41:17,410
+الـDioxyribose
+
+425
+00:41:17,410 --> 00:41:21,870
+مع الفوسفاب مع الـNitrogenous Base الثلاثة دولة
+
+426
+00:41:21,870 --> 00:41:26,120
+بنسميهم Nucleotide بيجوا هي كقطعة واحدةفالـ
+
+427
+00:41:26,120 --> 00:41:32,540
+Nucleotide هذا طبعاً بنسميه عادةً حسب الـ حسب شو
+
+428
+00:41:32,540 --> 00:41:42,000
+الـ Nitrogen Base فلما نيجي يعني نشوف الـ الـ
+
+429
+00:41:42,000 --> 00:41:48,760
+Double Helix هذا ماشي لو بدي أفرضه و بده أحط الـ
+
+430
+00:41:48,760 --> 00:41:53,260
+Nucleotide واحد ورا الثاني الحبل هذاراح يكون
+
+431
+00:41:53,260 --> 00:41:56,440
+تقريبًا بغطي الكورة الأرضية أو نص الكورة الأرضية
+
+432
+00:41:56,440 --> 00:42:01,860
+يعني مسافة طويلة جدًا ربنا حطه عشان تقدر تدخله كله
+
+433
+00:42:01,860 --> 00:42:04,960
+هيك في قطعة صغيرة في مكان صغير بتحشره في مكان صغير
+
+434
+00:42:04,960 --> 00:42:10,300
+إنك هيك بيصير يلف على بعضه أكثر وأكثر وأكثر فأول
+
+435
+00:42:10,300 --> 00:42:14,600
+Double Helix إذا بناخد نتصور كيف تركيبه على مستوى
+
+436
+00:42:14,600 --> 00:42:24,890
+إنه 2 نانومتر يعني 2×10 أو 2-9 متربصير بعدين يلف
+
+437
+00:42:24,890 --> 00:42:28,810
+بشكل أكبر طبعاً حتى تلفه بشكل أكبر بدك شوية
+
+438
+00:42:28,810 --> 00:42:33,670
+بروتينات بدك أشياء ثانية حتى تسمعله يلف أكثر عشان
+
+439
+00:42:33,670 --> 00:42:43,910
+يعرف يدخل وهذا اللي هو يعني اللي
+
+440
+00:42:43,910 --> 00:42:48,830
+بيسمونه «Nucleosome Fiber» اللي هو الـ Beads in a
+
+441
+00:42:48,830 --> 00:42:56,560
+Stringيعني عبارة عن أنه كل، عشان تقدر تخلّي تربطه
+
+442
+00:42:56,560 --> 00:43:01,700
+بشكل تستعرف تستعرف تعمل عملية Cell Division،
+
+443
+00:43:01,700 --> 00:43:07,840
+بحنأخد عنها وكيف تفصلها عن بعض، بتلاقي أن الـDNA
+
+444
+00:43:07,840 --> 00:43:12,520
+بلف بشكل أكثر
+
+445
+00:43:12,520 --> 00:43:17,880
+وأكثر وأكثركل ما أكبرت، بتشوف إنه فيه اسمه بيسموه
+
+446
+00:43:17,880 --> 00:43:23,020
+«نيكليوسون فايبر»، وبعدين اسمه «سلينويد»، ماشي،
+
+447
+00:43:23,020 --> 00:43:28,520
+وبعدين اللي هي الـ «سيلز إن إيرلي»، interface،
+
+448
+00:43:28,520 --> 00:43:33,580
+وبتكون الأمور بهذا الشكل الموضوع يعني حتى تتخيلوا
+
+449
+00:43:33,580 --> 00:43:41,910
+إنه لما أنا في خلية، بديأسوي عملية اللي بدنا
+
+450
+00:43:41,910 --> 00:43:46,510
+نتاخدها بعدين اللي هي عملية تحويل الـ DNA المادة
+
+451
+00:43:46,510 --> 00:43:51,270
+أو المعلومات اللي في الـ DNA أحولها لـ RNA بسميها
+
+452
+00:43:51,270 --> 00:43:56,430
+Transcription وبعدين لما أحول المادة أو المعلومات
+
+453
+00:43:56,430 --> 00:44:01,470
+اللي موجودة في الـ RNA لبروتين أسميها عملية
+
+454
+00:44:01,470 --> 00:44:05,250
+Translation فحتى أعمل عملية الـ Transcription هذه
+
+455
+00:44:05,250 --> 00:44:11,530
+بدي أخد قطعةتبعت الـ «جين» من الـ «DNA» وأفرطها
+
+456
+00:44:11,530 --> 00:44:16,490
+شوية السلة من اللي حكينا عنه بدي أبعده شوية عن بعض
+
+457
+00:44:16,490 --> 00:44:21,950
+وبدي أنقل المعلومات اللي موجودة على جهة عن طريق
+
+458
+00:44:21,950 --> 00:44:27,590
+Messenger RNA وبدي أسوي عملية Transcription هذه
+
+459
+00:44:27,590 --> 00:44:34,310
+بدي تكون الـ «DNA» فارض بدي تكون الـ «DNA» بعيد عن
+
+460
+00:44:34,310 --> 00:44:40,930
+بعضه وفارضأما لما بدي أجي أعمل عملية زي قضية الـ
+
+461
+00:44:40,930 --> 00:44:48,070
+Silk Division حتى إذا أنت بتتخيل معاك مثلا اللي هم
+
+462
+00:44:48,070 --> 00:44:55,310
+اللي بيشتغلوا الحجيات بالسنارة و بيكون معاهم خيط
+
+463
+00:44:55,310 --> 00:45:02,470
+ماشي إذا بدي أفصل مجموعة خيطين كرتين خيطان عن بعض
+
+464
+00:45:02,470 --> 00:45:09,540
+لو الخيط هيكي فالتوسيح ومفروض راح تلاقي أنه صعب
+
+465
+00:45:09,540 --> 00:45:14,420
+جدا تفصلن عن بعض بس لو أسير ألف الخيط لحيث أنه
+
+466
+00:45:14,420 --> 00:45:21,760
+أعمله بشكل طبي أعمله بشكل كتلة متماسكة ومربوطة على
+
+467
+00:45:21,760 --> 00:45:26,600
+بعض بيصير أن أفصل أثنتين هدول عن بعض سهل جدا ففي
+
+468
+00:45:26,600 --> 00:45:32,730
+حالةإنه بيكون الواحد بيشتغل على الـ DNA وبأخد منه
+
+469
+00:45:32,730 --> 00:45:35,470
+البروتينات وبأخد منه المعلومات وبسوّيله
+
+470
+00:45:35,470 --> 00:45:39,970
+Transcription وTranslation والأشياء هذه، بدي يكون
+
+471
+00:45:39,970 --> 00:45:44,590
+الـ DNA فارض وهي بيكون في مرحلة اللي بتسميها
+
+472
+00:45:44,590 --> 00:45:49,570
+Interface بتكون في المرحلة الخلية بتشتغل على الـ
+
+473
+00:45:49,570 --> 00:45:53,490
+DNA، بتشغّل الـ DNA وجيناتهوبتسوي الأشياء اللي
+
+474
+00:45:53,490 --> 00:45:59,570
+مطلوبة منه بس في لحظة معينة لما تتكلم عن إنه أنا
+
+475
+00:45:59,570 --> 00:46:05,450
+ما بدي الـ DNA هذا أشتغل عليه بهمني أن يكون الكرة
+
+476
+00:46:05,450 --> 00:46:11,310
+مطبوبة بالذات في وقت الـ Cell Division بيكون … ما
+
+477
+00:46:11,310 --> 00:46:17,850
+هو اسمه؟ بيكون … يعني Condensed بيكون مكثف، بيكون
+
+478
+00:46:17,850 --> 00:46:24,510
+مربوط على بعض، واضح؟فيه إشي فيه حد مش فاهم؟ فيه حد
+
+479
+00:46:24,510 --> 00:46:28,130
+عنده سؤال؟
+
+480
+00:46:28,130 --> 00:46:39,530
+واضح دكتور أحمد؟ إذا فيه حد عنده سؤال يسأل فهذا
+
+481
+00:46:39,530 --> 00:46:48,350
+نتكلم، نسميه اللي هنا يعني التركيب أو درجات تعقيد،
+
+482
+00:46:48,350 --> 00:46:49,850
+تركيب أو
+
+483
+00:46:54,000 --> 00:46:59,220
+الـ Packaging يعني اللي هي تغليف الـ DNA في الـ
+
+484
+00:46:59,220 --> 00:47:04,640
+Chromosome البشري فاللي بيبدأ من أنه الـ Double
+
+485
+00:47:04,640 --> 00:47:09,720
+Helix بعدين بيلف أكثر عن طريق الـ Histone راح نحكي
+
+486
+00:47:09,720 --> 00:47:13,600
+عنه مرات فيه له أهميات في أمراض وأحالات وأشياء
+
+487
+00:47:14,320 --> 00:47:19,180
+وبعدين بنشكله على شكل الـ Steel، الـ Slinoids
+
+488
+00:47:19,180 --> 00:47:25,980
+وبعدين بيكون موجود سواء في حالة الـ Interface أو
+
+489
+00:47:25,980 --> 00:47:29,580
+في حالة لما نعمل الـ Cell Division لقضية أن عندي
+
+490
+00:47:29,580 --> 00:47:34,680
+يكون كرموزومات مثبتة على بعض، بتغليف معين، بترتيب
+
+491
+00:47:34,680 --> 00:47:39,920
+معين، في أسئلة؟ ‏- سيهم، عندها سؤال ‏- أه، اسألي
+
+492
+00:47:41,510 --> 00:47:46,170
+بتسأل إنه كيف بيكون مفكوك في انقسام الخلية أعتقد
+
+493
+00:47:46,170 --> 00:47:51,890
+جزد عن الـ«نيكليوزوم فايبر» يعني أو بشكل عام
+
+494
+00:47:51,890 --> 00:47:57,110
+الـDNA واحنا لازم نقسمها لخليتين لأ، لأ، لأ، أنت
+
+495
+00:47:57,110 --> 00:48:06,930
+الآن الـDNA بيكون بين حالتين في حالة بدي أقرا
+
+496
+00:48:06,930 --> 00:48:11,230
+المادة اللي فيه عشان أكول بروتين الخلية هذه بدهيها
+
+497
+00:48:11,880 --> 00:48:16,900
+فعشان تقراه، راح ناخد بعد شوية راح يكون إنه لازم
+
+498
+00:48:16,900 --> 00:48:22,360
+الـ DNA هذا يكون فارق يعني لازم يكون حتى الـ
+
+499
+00:48:22,360 --> 00:48:27,480
+Double Strand هذا اللي هو هنا لازم يكون نفصله عن
+
+500
+00:48:27,480 --> 00:48:32,820
+بعض عشان تعرف نصل إله يعني هذه الـ … الـ … الـ
+
+501
+00:48:32,820 --> 00:48:37,460
+chromosome الواحد راح ناخد ما لا يقل عن ألف gene
+
+502
+00:48:37,460 --> 00:48:41,750
+فيهيعني بيكون فيه عدد كبير من الجينات مش كلها
+
+503
+00:48:41,750 --> 00:48:46,910
+شغالة مش كلها بده يتم يعني عملية الـ Transcription
+
+504
+00:48:46,910 --> 00:48:52,330
+تبعتها لـ RNA بده يكون عدد قليل بس اللي شو اسمه
+
+505
+00:48:52,330 --> 00:48:57,510
+محتوط الـ DNA اللي يعني بتصير عملية الـ
+
+506
+00:48:57,510 --> 00:49:02,250
+Transcription يعني في أي خلية عدد قليل من الجينات
+
+507
+00:49:02,250 --> 00:49:05,610
+بتتم قراءتها اللي هي عملية الـ Transcription
+
+508
+00:49:05,610 --> 00:49:09,640
+تبعتهافلما أنا بدي أعمل transcription بدي أكون
+
+509
+00:49:09,640 --> 00:49:14,120
+فارض زي هيكي بس لما أجي أعمل عملية cell division
+
+510
+00:49:14,120 --> 00:49:20,460
+بدي أكون انبكت مظبوط بشكل بحيث أنه أفصله عن بعض
+
+511
+00:49:20,460 --> 00:49:27,140
+كخطعتين فهنجي ناخد صورة عنها، في واضحة؟ لسه عن
+
+512
+00:49:27,140 --> 00:49:30,800
+سياق المشكلة؟
+
+513
+00:49:30,800 --> 00:49:39,160
+لأ لأ الأمور واضحة بالنسبة لهافيعني هذه صورة
+
+514
+00:49:39,160 --> 00:49:46,600
+بالنسبة لكيف تركيب الأمور لما ناخد الـ Chromosome
+
+515
+00:49:46,600 --> 00:49:52,180
+الـ Chromosome يعني تقريباً راح ناخد أوصافه
+
+516
+00:49:52,180 --> 00:49:58,690
+وأشكاله وكذابارعاً شكل بالأخير يعني ممكن يكون على
+
+517
+00:49:58,690 --> 00:50:06,670
+شكل حبل طويل وهكذا ولمّا نأخذه بشكل اللي هو عند
+
+518
+00:50:06,670 --> 00:50:11,810
+اللي بيسموه في الـ Karyotype من اللي بيسموه عند
+
+519
+00:50:11,810 --> 00:50:19,150
+دراسة الكرمозومات تبع الإنسان بشكل كبير فاحنا ناخد
+
+520
+00:50:19,150 --> 00:50:24,390
+على شكل واحدة هذه الدراسات، بيكونلو أخدنا هذا الـ
+
+521
+00:50:24,390 --> 00:50:27,690
+Chromosome ويكون بهذا الشكل فيه إشي بيسموه
+
+522
+00:50:27,690 --> 00:50:32,150
+Centromere اللي هي النقطة الأهم في قضية فصل
+
+523
+00:50:32,150 --> 00:50:36,470
+القطعتين عن بعض اللي هي بتداخل مع الـ Centrosome
+
+524
+00:50:36,470 --> 00:50:44,230
+وبيفصل الـ Two copies of DNA عن بعض لما نيجي ناخد
+
+525
+00:50:44,230 --> 00:50:49,190
+شكله عن طريق هنا شكلها Electron Microscopy اللي
+
+526
+00:50:49,190 --> 00:50:53,440
+أقيا بالأخير عبارة عن خاتم لو لولو جيت على قطعة
+
+527
+00:50:53,440 --> 00:50:57,560
+صغيرة من هذه الخيطة راح ألاقيها زي هيك دي عندى الـ
+
+528
+00:50:57,560 --> 00:51:02,280
+Double Helix الـ Double Helix يعني تلم لو لبيه
+
+529
+00:51:02,280 --> 00:51:11,360
+بينهم دعسات بتكون بنفس الترتيب فالأصل تكون مثلًا،
+
+530
+00:51:11,360 --> 00:51:17,960
+هاي على و بناخدها إنه أنا بقرا من الطرف رقم خمسة
+
+531
+00:51:17,960 --> 00:51:22,250
+«5 Prime» لـ «3 Prime»الطرف الثاني راح يكون من
+
+532
+00:51:22,250 --> 00:51:25,630
+الـ5 Prime لـ3 Prime بيكون هذا هو شكل
+
+533
+00:51:25,630 --> 00:51:31,530
+الـDeoxyribose زي الفوسفيل أما بالنصف بيكون
+
+534
+00:51:31,530 --> 00:51:36,270
+الـNitrogen Basis فهذه لما نقول إحنا قرينا
+
+535
+00:51:36,270 --> 00:51:42,390
+الـSequencing تبع الـDNA بنقول شو هي الأحرف تبعات
+
+536
+00:51:42,390 --> 00:51:49,580
+الـNitrogen Basis الموجود وعادة بناخدها دايماًمن
+
+537
+00:51:49,580 --> 00:51:55,520
+الـ5 للـ3، هيك المتعارف على أساس إن الـ3 للـ5
+
+538
+00:51:55,520 --> 00:52:02,460
+بيكون أكسر، ماشي؟ فلو أخذنا إنه أنا عندي بني آدم
+
+539
+00:52:02,460 --> 00:52:08,320
+معين اللي عملوله Human Genome، شو اسمه الـHuman
+
+540
+00:52:08,320 --> 00:52:14,320
+Genome، للقطعة هذه في الـChromosome هذا، للبروتين،
+
+541
+00:52:14,320 --> 00:52:19,490
+الله أعلم شو اللي راح يكون، يطلعه، باخد، آسف،بأخد
+
+542
+00:52:19,490 --> 00:52:23,910
+إنه هذا هو الـ Double Helix وهكذا يكون الـ
+
+543
+00:52:23,910 --> 00:52:28,410
+Reference Sequence لما نتعامل إحنا كعلماء وطباء
+
+544
+00:52:28,410 --> 00:52:31,850
+نيجي مثلا نتناقش بعد شوية على «تميليا»
+
+545
+00:52:31,850 --> 00:52:36,150
+الـMediterranean fever و لا أي مرض وراثي تاني،
+
+546
+00:52:36,150 --> 00:52:39,370
+بتلاقي لما نقول على القطعة هذه وشو هو الـReference
+
+547
+00:52:39,370 --> 00:52:44,260
+Sequence اللي إحنا بنستخدمه، تلقائيًا راح ناخدعشان
+
+548
+00:52:44,260 --> 00:52:48,160
+ما أتعقدش الموضوع من الخمس إلى الثلاث فدايماً
+
+549
+00:52:48,160 --> 00:52:52,760
+بقراهم من الخمس إلى الثلاث فهنا عملوا تجربة إنه
+
+550
+00:52:52,760 --> 00:52:57,700
+جابوا خمس أشخاص درسوا
+
+551
+00:52:57,700 --> 00:53:04,400
+هذه القطعة وشافوا الـSequence تبعها ولقوا إنه في
+
+552
+00:53:04,400 --> 00:53:09,720
+حالة مثلا الشخص الأول كان اللي هو الـReference
+
+553
+00:53:09,720 --> 00:53:14,180
+Sequence وكان هو أول إنسان إحنا درسناهفما جيبنا
+
+554
+00:53:14,180 --> 00:53:18,720
+بني آدم ثاني وعندي حسا الأن إمكانيات إني أدرس
+
+555
+00:53:18,720 --> 00:53:26,020
+الاختلافات الـ Polymorphism اللي هي الـ الـ الـ
+
+556
+00:53:26,020 --> 00:53:31,240
+يعني الاختلافات حتى على مستوى single nitrogen
+
+557
+00:53:31,240 --> 00:53:36,780
+bases فبحيث إنه الشخص الأول والشخص الثاني في هذا
+
+558
+00:53:36,780 --> 00:53:41,620
+المكان بدل ما هي الـT زي ما هو بالـReference في C
+
+559
+00:53:41,620 --> 00:53:48,110
+وCفهذه طبعًا الـ «T» بيكون إقبالها «A» فلما يكون
+
+560
+00:53:48,110 --> 00:53:53,750
+هنا «C» بيكون إقبالها «G» فهذولة Individual 2، 3
+
+561
+00:53:53,750 --> 00:53:57,850
+عندهم هذا الخلال في هذا المكان بقول على الموقع،
+
+562
+00:53:57,850 --> 00:54:04,310
+هذا بسمي 1، 2، 3، 4، 5، 6، 7، هنا رقم 8، هنا رقم
+
+563
+00:54:04,310 --> 00:54:14,080
+مثلًا 20 بدل ما هي «C» كانت «A»الشخص الخامس تم
+
+564
+00:54:14,080 --> 00:54:21,320
+إزالة إثنين نيكليوتايد أو إثنين Bases بحيث إن الـ
+
+565
+00:54:21,320 --> 00:54:27,020
+«T» أجت بعد «C» فهي أقصر طبعاً هنا بيحاولوا إنه،
+
+566
+00:54:27,020 --> 00:54:34,440
+شو اسمه، يعني هذه الأخيرة زي ما هم شرحينكم هنا،
+
+567
+00:54:34,440 --> 00:54:40,620
+هنا صار «Deletion» يعني لسبب أو لآخر انقطعالـ Two
+
+568
+00:54:40,620 --> 00:54:44,300
+Nucleotides إن شاء الله فالـ T أجت وراها بعدها الـ
+
+569
+00:54:44,300 --> 00:54:48,300
+C يعني هاي الـ T أجت بدل ما يكون فيه Two Ts بعدها
+
+570
+00:54:48,300 --> 00:54:52,120
+من تان تيات أجت بعدها الـ C مباشرة فالمفروض هذا
+
+571
+00:54:52,120 --> 00:54:57,840
+يكون شكله أصغر فهذا بيعمل برضه خاصية ويرافية أخرى
+
+572
+00:54:57,840 --> 00:55:03,640
+فالمطلوب هنا أو الفكرة اللي بيشرحوها هنا إنه
+
+573
+00:55:03,640 --> 00:55:07,360
+الترتيب
+
+574
+00:55:09,120 --> 00:55:17,620
+القواعد النيتروجينية في الـ DNA هو ما يتحكم
+
+575
+00:55:17,620 --> 00:55:22,880
+بالأحرف أو الـ Amino Acids اللي راح تيجي بالبروتين
+
+576
+00:55:22,880 --> 00:55:29,380
+اللي راح تيجي في الـ اللي تمثل المادة الوراثية
+
+577
+00:55:29,380 --> 00:55:40,160
+وتمثل المظهر الخارجي بعدين لأي كل إنسان، ففي حد
+
+578
+00:55:40,160 --> 00:55:46,040
+بيسأل سؤال، يلّا إذا أسأله، شو السؤال؟ أنا مش شايف
+
+579
+00:55:46,040 --> 00:55:56,860
+الـChat وحتى صورتي راحت، آه، في سؤال؟
+
+580
+00:55:56,860 --> 00:56:07,100
+في واحد رفع إيده، كريم، دكتور أحمد،
+
+581
+00:56:14,510 --> 00:56:19,670
+الدكتور أحمد، في حد عنده سؤال أنا أشوف إذا في الـ
+
+582
+00:56:19,670 --> 00:56:39,930
+«تشات»، وين الـ«تشات»؟ ماشي،
+
+583
+00:56:39,930 --> 00:56:48,140
+الأحيانًايعني مش ضروري الإنسان الأول هو يكون، شو
+
+584
+00:56:48,140 --> 00:56:54,160
+اسمه؟ هو السليم والتاني مصاب إحنا هنا الفكرة إنه
+
+585
+00:56:54,160 --> 00:57:02,340
+أنا من دراستي لتركيب الـDNA بسوي Sequence لإيش هم،
+
+586
+00:57:02,340 --> 00:57:07,960
+ليه واحدة من أربعة من الـNitrogen Bases
+
+587
+00:57:07,960 --> 00:57:11,420
+الـNitrogen Bases دو بالأخير هم اللي بتحكموا
+
+588
+00:57:11,420 --> 00:57:19,520
+بالبروترفلما أنا آجي أدرس مثلا نفترض أنه بدي أدرس
+
+589
+00:57:19,520 --> 00:57:24,940
+الـ gene تبع الـ Alpha chain تبع الـ hemoglobin
+
+590
+00:57:24,940 --> 00:57:33,320
+فبروح بشوف إنسان مثلا الشخص الأولمثلاً اللي هو
+
+591
+00:57:33,320 --> 00:57:37,120
+«باعتبره أنه كان طبيعي» «والإنسان اللي ماعلوش
+
+592
+00:57:37,120 --> 00:57:41,460
+مشكلة» «وباعتبره طبيعي» يعني أحيانًا الـReference
+
+593
+00:57:41,460 --> 00:57:45,480
+Sequence هذا ممكن يكون لإنسان مريض أو إنسان طبيعي
+
+594
+00:57:45,480 --> 00:57:50,000
+بس هو الأول اللي اعتمدنا عليه في دراسة هذا القطعة
+
+595
+00:57:50,000 --> 00:57:54,900
+من الـDNA يعني هذه الفكرة الأولى فإذا أنا الإنسان
+
+596
+00:57:54,900 --> 00:58:02,110
+الأول كان بهذا الشكل وبعدينبدرس شخص تاني وثالث
+
+597
+00:58:02,110 --> 00:58:07,170
+ورابع وخامس وعشر ومليون ومليونين بقدر أظن أدرس،
+
+598
+00:58:07,170 --> 00:58:13,650
+بشوف شو الاختلافات وبتكون إنه أنا في الأصل في
+
+599
+00:58:13,650 --> 00:58:22,230
+الغالب العمود الفقري تبع ترتيب الـ «جين» هذا لهذا
+
+600
+00:58:22,230 --> 00:58:28,950
+البروتين بكون بشكل معين، فبعتبره الأساسيلما أجي
+
+601
+00:58:28,950 --> 00:58:35,750
+أسوي report لـ الـ reference sequence هذا هو تبع
+
+602
+00:58:35,750 --> 00:58:42,230
+أول إنسان درسناه أو أول إنسان سويتله sequence على
+
+603
+00:58:42,230 --> 00:58:48,510
+افتراض أنه إنسان طبيعي فلما أجي أجيب لإنسان ثاني
+
+604
+00:58:48,510 --> 00:58:54,380
+وهنا أنا سويت لأربعة غيره لاقيت أنهOkay، هذا
+
+605
+00:58:54,380 --> 00:58:58,320
+الإنسان الأول بهذا الشكل فيه شخصين كان عندهم
+
+606
+00:58:58,320 --> 00:59:03,540
+بيسموه Single Nucleotide Polymorphism يعني فيه
+
+607
+00:59:03,540 --> 00:59:11,700
+تفديل في موقع معين لحرف تبع الـNitrogen Space وفي
+
+608
+00:59:11,700 --> 00:59:17,180
+شخص رابع عنده اختلاف في محل تاني بنوعية أخرى وفي
+
+609
+00:59:17,180 --> 00:59:22,960
+شخص ثالث، خامسكان، ما هو اسمه؟ حتى فيه الـDeletion
+
+610
+00:59:22,960 --> 00:59:26,580
+فطبعاً الـDeletion راح تقصر، راح تغير كله، راح
+
+611
+00:59:26,580 --> 00:59:32,020
+تتغير بشكل كبير يعني يمكن الاختلافات اللي موجودة
+
+612
+00:59:32,020 --> 00:59:38,260
+عند 2 و3 و4 اختلافات بسيطة، يمكن ما تكونش مؤثرة
+
+613
+00:59:38,260 --> 00:59:42,440
+لأنه راح ناخد بعد شوية إنه أحياناً حتى لو تغيرت
+
+614
+00:59:42,440 --> 00:59:47,960
+الـNucleotideونوعية الـ Nitrogen Base ممكن ما
+
+615
+00:59:47,960 --> 00:59:51,440
+يتغير البروتين يعني مش دايماً لازم يتغير البروتين
+
+616
+00:59:51,440 --> 00:59:55,780
+بس لما يبدأ تنشالة فنتين هدولة يصير الـ Deletion
+
+617
+00:59:55,780 --> 01:00:02,260
+هذا خطأ يعني راح يخرّب كل الشغل يعني آه، في أسئلة؟
+
+618
+01:00:02,260 --> 01:00:08,880
+دكتور، في يعني ردت أسئلة كانت في الـChat وفي كريم
+
+619
+01:00:08,880 --> 01:00:13,160
+بده يحكي آه، يحكي أول حاجة، دعنا نشوف كريم
+
+620
+01:00:17,480 --> 01:00:24,700
+فضّالة كريم يطيبك العرف يا دكتور أول حاجة اللي
+
+621
+01:00:24,700 --> 01:00:28,980
+أخدنا في مساق سابق أنه الجين اللي عند الإنسان
+
+622
+01:00:28,980 --> 01:00:34,580
+تقريبا 99% متشابه كل الناس متشابه فيه وبظال نسبة 1
+
+623
+01:00:34,580 --> 01:00:37,980
+% أن هذه اللي هي الـdifferent أو بتتميز الناس عن
+
+624
+01:00:37,980 --> 01:00:43,880
+بعض صح الكلام صح؟ لأ مش ضروري هيك ما بذكر أنه قريت
+
+625
+01:00:43,880 --> 01:00:51,670
+هذا الموضوع هيك فيه تفاصيل كتيرةشوف حوالي تقريبًا
+
+626
+01:00:51,670 --> 01:00:57,810
+يعني 95% من الـ «DNA» تبع الإنسان بيسموه «Non
+
+627
+01:00:57,810 --> 01:01:06,290
+-coding DNA» يعني هذا الـ «اسام» مش كل الـ «DNA»
+
+628
+01:01:06,290 --> 01:01:14,680
+تبع الإنسان فيه جيناتفيه زي ما تقول عبارة عن فراطة
+
+629
+01:01:14,680 --> 01:01:20,440
+كثير لقضية اللف والـ Packaging وكذا ففيه نسبة
+
+630
+01:01:20,440 --> 01:01:24,720
+كبيرة على عكس الحيوانات الأخرى في كائنات حي ثانية
+
+631
+01:01:24,720 --> 01:01:28,480
+تقريبًا كل الـ DNA تبعها يستخدم في الـ
+
+632
+01:01:28,480 --> 01:01:32,720
+Transcription والـ Translation لإنه يكون ينتج عنه
+
+633
+01:01:32,720 --> 01:01:42,170
+البروتين فبالنسبة للإنسانجزء كبير مش مهم، بس بين
+
+634
+01:01:42,170 --> 01:01:48,390
+البشر هل هناك اختلافات في الـ «DNA»؟ فيه أشياء
+
+635
+01:01:48,390 --> 01:01:53,970
+يحافظ عليها، وبتكون مدى إذا قطعة صغيرة أو أنواع
+
+636
+01:01:53,970 --> 01:01:58,330
+ولا كده، يعني بس فيه اختلافات، يعني أنت لما تيجي
+
+637
+01:01:58,330 --> 01:02:05,570
+تاخد مثلًا لموقع الـ «ABO System»، ماشي؟الـ «جين»
+
+638
+01:02:05,570 --> 01:02:11,350
+مثلًا، في ناس «A» و«B» و«AB» و«O» باختلاف، لو انت
+
+639
+01:02:11,350 --> 01:02:14,990
+واخد الـ «HLA System» فيه اختلافات كبيرة على مستوى
+
+640
+01:02:14,990 --> 01:02:19,810
+إنه ما لا يقل على الـ «HLA» مثلًا، «A» فيه حوالي
+
+641
+01:02:19,810 --> 01:02:25,650
+300، 400 نوع، فما تقولي إن البشر كلهم متشابين، بس
+
+642
+01:02:25,650 --> 01:02:31,350
+نسبة كبيرة من الـ «DNA» تبع الإنسانلأ، ما بيتم
+
+643
+01:02:31,350 --> 01:02:35,850
+تحويله
+
+644
+01:02:35,850 --> 01:02:38,850
+إلى Transcription أو Translation فهذه يعطينا
+
+645
+01:02:38,850 --> 01:02:43,970
+البروتين، فبيعتبروه Non-coding وهذا أحيانًا مهم في
+
+646
+01:02:43,970 --> 01:02:55,030
+عملية التحكم في تكوين البروتين يعني، لأ يعني، بدك
+
+647
+01:02:55,030 --> 01:03:02,420
+تتخيل مثلًاأنا عندي بروتين، سامعني يا كريم؟ آه
+
+648
+01:03:02,420 --> 01:03:08,720
+تمام. هسة مثلا، البروتين، الـGene تبع
+
+649
+01:03:08,720 --> 01:03:15,280
+الـHemoglobin، ماشي؟ وين موجود؟ في الـDNA، صح؟
+
+650
+01:03:15,280 --> 01:03:24,600
+أنيه خلية فيها هذا البروتين، الـGene؟ جاوبني، شو
+
+651
+01:03:24,600 --> 01:03:31,830
+رايك؟ في الـRBCلأ، طبعًا الـ «جين» الـ «جين» تبع
+
+652
+01:03:31,830 --> 01:03:37,870
+الـ Hemoglobin موجود في كل الخلايا، شايف علي؟ كله
+
+653
+01:03:37,870 --> 01:03:42,990
+زي بعض، الـ DNA صحيح، كان في جواب من الكل إنه
+
+654
+01:03:42,990 --> 01:03:47,070
+موجود في كل الخلايا، صحيح؟ آه، فهو موجود في كل
+
+655
+01:03:47,070 --> 01:03:52,540
+الخلايا، بسفقط في الـ Red Blood Cells بتم تفعيل
+
+656
+01:03:52,540 --> 01:03:57,080
+هذا الجين بالذات بس عشان ينتجلي الـ Hemoglobin
+
+657
+01:03:57,080 --> 01:04:01,280
+فبهذه الناحية بدنا نفهمها يعني خلية الجل بيدا
+
+658
+01:04:01,280 --> 01:04:03,680
+كيراتين بدهاش Hemoglobin، شوف ده بالـ Hemoglobin
+
+659
+01:04:03,680 --> 01:04:08,160
+خلية الـ B-Lymphocytes بتطلع Immunoglobin خلية الـ
+
+660
+01:04:08,160 --> 01:04:13,120
+T-Cells بالمنعقة بتطلعك كذا، خلية كذا كل واحدة حسب
+
+661
+01:04:13,120 --> 01:04:17,540
+شغلها بتشغل إشي وبدهاش الأشياء التانيةفالأشياء
+
+662
+01:04:17,540 --> 01:04:23,320
+الثانية بتظلها خاملة، بتظلها ساكتة في الإنسان
+
+663
+01:04:23,320 --> 01:04:28,640
+بالذات، نسبة كبيرة من الـ DNA بيسموه Non-coding
+
+664
+01:04:28,640 --> 01:04:32,700
+DNA يعني ما بيتم استفادة منه في عملية الـ
+
+665
+01:04:32,700 --> 01:04:35,300
+Transcription و Translation بحيث يعطينا الـ
+
+666
+01:04:35,300 --> 01:04:41,530
+Protein، ولكناللي يعني بيظنوا إنه له دور في
+
+667
+01:04:41,530 --> 01:04:44,750
+الحماية من الـ mutation يعني لو صار خراب في هذا
+
+668
+01:04:44,750 --> 01:04:48,190
+الجزء ما هو non-coding مش مهم كثير، من ناحية
+
+669
+01:04:48,190 --> 01:04:54,710
+والناحية الثانية إنه بتحكم في أينه خلية نشغل هذا
+
+670
+01:04:54,710 --> 01:04:59,210
+الـ gene يعني هيك يعني، فياسة أخرى فالآن اللي
+
+671
+01:04:59,210 --> 01:05:07,000
+قدامنا يعني إنه على العكس الـ single nucleotideالـ
+
+672
+01:05:07,000 --> 01:05:14,780
+Polymorphism اللي هي هذه الظاهرة في هذه الرسمة
+
+673
+01:05:14,780 --> 01:05:19,000
+علاقة شائعة جداً جداً ومرات ما لهاش قيمة يعني لأنه
+
+674
+01:05:19,000 --> 01:05:23,540
+راح ناخد بعد شوية الـ Triplets هدولة اللي هي كل
+
+675
+01:05:23,540 --> 01:05:26,380
+ثلاثة نيوكليوتات بيعطينا واحد Amino Acid زي ما
+
+676
+01:05:26,380 --> 01:05:31,400
+بتعرفوا هذه بتتم من خلال أن أحيانًا أكثر من
+
+677
+01:05:31,400 --> 01:05:33,240
+Triplets لأنه
+
+678
+01:05:41,210 --> 01:05:42,610
+4×4×4×4×4×4×4×4×4×4×4×4×4×4×4×4×4×4×4×4×4×4×4×4×4×4
+
+679
+01:05:44,260 --> 01:05:48,260
+فيها سؤال أخر؟ دكتور، في المعظم يعني بيقول إيش
+
+680
+01:05:48,260 --> 01:05:53,080
+الفكرة اللي بده توصلها الـslide؟ يعني هم قضية
+
+681
+01:05:53,080 --> 01:05:57,180
+الـReference Sequence بناخده إحنا عن أحد
+
+682
+01:05:57,180 --> 01:05:59,960
+الـStrands تبعوت اللي هو الـDouble Helical بيشكل
+
+683
+01:05:59,960 --> 01:06:02,840
+كرمزوم وبيطلع عندنا فيه اختلافات ما بين
+
+684
+01:06:02,840 --> 01:06:05,880
+الـIndividuals مع الـReference Sequence إيش الفكرة
+
+685
+01:06:05,880 --> 01:06:09,700
+اللي أنا بده أصلها يعني معلومة اللي بدي توصلها
+
+686
+01:06:09,700 --> 01:06:13,380
+الـslide بشكل عام؟ هم هيك السؤال يعني آه، الفكرة
+
+687
+01:06:13,380 --> 01:06:21,200
+إنهلما أنا في العلم لما بدأ أدرس موضوع بدأت القضية
+
+688
+01:06:21,200 --> 01:06:25,360
+حكينا من قبل اسم الـ Human Genome الـ Human Genome
+
+689
+01:06:25,360 --> 01:06:30,000
+أخدوا بني آدم واحد فانت بدأت تبدأ في مرحلة معينة
+
+690
+01:06:30,000 --> 01:06:33,940
+فلما تبدأ أخذنا الـ Human Genome أنا أظن يعني هاي
+
+691
+01:06:33,940 --> 01:06:39,500
+واحد ذكرليها كمعلومة إنه الإنسان ما هو بدك تاخد
+
+692
+01:06:39,500 --> 01:06:43,700
+إنسان واحد لأن كلنا مختلفين عن بعضشايف عليا؟ ناخد
+
+693
+01:06:43,700 --> 01:06:46,900
+مادة وراثية من الأب ومن الأم ومن الـ Mitochondria
+
+694
+01:06:46,900 --> 01:06:51,660
+لوحده وكذا أنا أظن أسمعت إنه بيقولوا إنه مدير
+
+695
+01:06:51,660 --> 01:07:01,380
+البنك الدولي اللي هو موّل بمليارات المشروع
+
+696
+01:07:01,380 --> 01:07:04,700
+الـ Human Genome هو الإنسان اللي أخذوا الـ DNA
+
+697
+01:07:04,700 --> 01:07:09,950
+تبعه أنت بدك تبدأ في لحظة معينةكيف بدك يعني من وين
+
+698
+01:07:09,950 --> 01:07:15,250
+بدك تعرف أنه يعني بد يكون عندك مرجع بالأول ترجعله
+
+699
+01:07:15,250 --> 01:07:19,470
+تقيس باقية الأشياء عليه يمكن هذا الإنسان هو عنده
+
+700
+01:07:19,470 --> 01:07:23,610
+أمراضه عنده اختلافات معينة عن غيره فهل
+
+701
+01:07:23,610 --> 01:07:26,530
+الـReference Sequence هو أشياء، إشي دايماً ما بعرف
+
+702
+01:07:26,530 --> 01:07:32,350
+يعني ماعندي معلومة إنه هو إشي طبيعي يعني مافيش إشي
+
+703
+01:07:32,350 --> 01:07:37,820
+اسمه طبيعي بينما كل إنسان له ميزات معينةفلما
+
+704
+01:07:37,820 --> 01:07:42,520
+انتوا، الواحد بعدين راح ياخد كيف ببحث في المواضيع
+
+705
+01:07:42,520 --> 01:07:47,540
+هذه وبسوي Blast وبسوي بعد الـSequencing أو بستخدم
+
+706
+01:07:47,540 --> 01:07:52,440
+PCR وكده، لما انت قيم هذا الموضوع، بدخل على قواعد
+
+707
+01:07:52,440 --> 01:07:57,420
+البيانات تبع الترتيب، الـSequence هذا، بشوف هذا
+
+708
+01:07:57,420 --> 01:08:04,290
+بشبه أيش وبصير أقارن فيه، فلازم أنا بالأول أاخدلأي
+
+709
+01:08:04,290 --> 01:08:09,550
+جين أو لأي مكان سيكوينس معين بصير أعتبره هذا هو
+
+710
+01:08:09,550 --> 01:08:15,090
+الـReference وبصير بعدين أشوف لما أخد حالي ثاني أو
+
+711
+01:08:15,090 --> 01:08:21,010
+شخص آخر أو إنسان آخر بشوف قداش درجة الاختلافات
+
+712
+01:08:21,010 --> 01:08:27,390
+وبقيم وضع هذا القطعة من الـDNA أو هذا الجين آه،
+
+713
+01:08:27,390 --> 01:08:33,290
+واضح؟يا دكاتر أو يا دكتور، إذا كان الصورة واضحة أو
+
+714
+01:08:33,290 --> 01:08:38,890
+المطلوب من الـslide واضح، يعني بنكمل، إسألوا مرة
+
+715
+01:08:38,890 --> 01:08:42,690
+ثانية، مافي مشكلة، الدكتور طبعاً مافي عنده مشكلة
+
+716
+01:08:42,690 --> 01:08:49,550
+إنه يوضح النقطة بالزيادة الـHuman Genome بس انتهى،
+
+717
+01:08:49,550 --> 01:08:55,210
+يعني هو البدايةوالكلام من سنة الـ، يعني خلص يمكن
+
+718
+01:08:55,210 --> 01:09:01,030
+أظن 2003، 2004 إنه عملوا الـSequence لكل إنسان
+
+719
+01:09:01,030 --> 01:09:06,030
+واحد واعتبروه هو Reference Sequence فلما واحد
+
+720
+01:09:06,030 --> 01:09:12,530
+يدرس، يعني أنا لما أجي مثلا أدرس ظاهرة معينة في
+
+721
+01:09:12,530 --> 01:09:18,010
+المناعة مثلا، بلاقي مرات بروتين، باكتشف بروتين
+
+722
+01:09:18,010 --> 01:09:18,510
+جديد
+
+723
+01:09:21,620 --> 01:09:26,300
+بحاول أشوف شو كان الـ «DNA Sequence» اللي بعطينا
+
+724
+01:09:26,300 --> 01:09:32,740
+هذا البروتين لما أفهم وأقدر ألاقي وين هذا الاشي
+
+725
+01:09:32,740 --> 01:09:38,900
+موجود في الـ «Chromosome» وفي الـ «DNA» بسير بعدين
+
+726
+01:09:38,900 --> 01:09:46,060
+مرحلة أخرى متقدمة أكثر ألاحظ شو هن اختلافات البشر
+
+727
+01:09:46,060 --> 01:09:53,060
+عموما عنالـ Standard أو عن الـ Reference فبصير أنا
+
+728
+01:09:53,060 --> 01:09:56,980
+في حالات أمراض، في حالات عائلات، في حالات يعني مش
+
+729
+01:09:56,980 --> 01:10:00,600
+ضروري individual one ولا two، three، أن يكون مريض،
+
+730
+01:10:00,600 --> 01:10:05,160
+ممكن يكون، لأ، هي بس أنه في اختلافات، يعني إنه هذه
+
+731
+01:10:05,160 --> 01:10:11,540
+ظاهرة موجودة قداش نسبتها 100% بالنسبة للدراسات،
+
+732
+01:10:11,540 --> 01:10:17,510
+لإيش هي والله أنا ما بعرف يعني إنها بالكم يعنيطب
+
+733
+01:10:17,510 --> 01:10:21,570
+يا دكتور أنا بدي أنقل سؤال و بدي أسأل أنا برضه
+
+734
+01:10:21,570 --> 01:10:27,210
+سؤال بقيت بقضية الـReference Sequence مثلا الشخص
+
+735
+01:10:27,210 --> 01:10:33,670
+اللي تم أخده لعملية الـGenome Sequencingهل تم
+
+736
+01:10:33,670 --> 01:10:39,330
+افتراض أنه هو الـ Normal؟ يعني ما تستطيع أن تبقى
+
+737
+01:10:39,330 --> 01:10:44,930
+هو الـ Normal؟ أه صحيح، وممكن
+
+738
+01:10:44,930 --> 01:10:51,810
+يكون في عضل الجينات لأمراض لكن ما تم ترجمتها أو
+
+739
+01:10:51,810 --> 01:10:56,270
+غير ظاهرة، فبالتالي الـ Referenceأه صحيح، يعني
+
+740
+01:10:56,270 --> 01:10:59,890
+السؤال هل الـ «reference» هو اللي هيكون مرجع
+
+741
+01:10:59,890 --> 01:11:04,750
+لدراسة بس مقارنة ومشابهة، مش مرجع إنه نقول ما ..
+
+742
+01:11:04,750 --> 01:11:09,170
+ما .. عقل ما بقدر أقول إن هذا إنسان سليم وغيره هو
+
+743
+01:11:09,170 --> 01:11:15,230
+إنسان مريض، لأ، ما مش إيه، بس ك .. لما تيجي تدرس
+
+744
+01:11:15,230 --> 01:11:22,190
+ال .. يعني طبعا إحنا بنتكلم عن حوالي خمس وعشرين
+
+745
+01:11:22,190 --> 01:11:27,680
+ألف geneاللي هو اللي يعني بتوقعوا إنه فيها إلى
+
+746
+01:11:27,680 --> 01:11:32,260
+بيسموه الـ Promoter والـ End codon واللي هي يعني
+
+747
+01:11:32,260 --> 01:11:36,120
+القطعة اللي بتتم ترجمتها من خلال الـ Transcription
+
+748
+01:11:36,120 --> 01:11:41,360
+للـ RNA وبعدين الـ Protein فالقطع اللي زي هيك فيه
+
+749
+01:11:41,360 --> 01:11:47,360
+حوالي 25 ألف Gen فالـ الـ الآن النقطة اللي بدل
+
+750
+01:11:47,360 --> 01:11:57,600
+واحد يصلها إنهلأغراض عملية إيجاد مرجعية لدراسة هذه
+
+751
+01:11:57,600 --> 01:12:05,520
+المواضيع تم عمل الـ Human Genome ومنه بيتم يعني
+
+752
+01:12:05,520 --> 01:12:10,340
+افتراض Reference Sequence اللي هو لقوه عند الإنسان
+
+753
+01:12:10,340 --> 01:12:15,600
+الأول اللي درسوهوبعدين بسير لما قاعد أدرس شخص
+
+754
+01:12:15,600 --> 01:12:20,260
+ثاني، ثالث، عائلة، عائلتين الـ populations مثلا كل
+
+755
+01:12:20,260 --> 01:12:25,180
+البيض السود الصينيين، الـ كذا، الـ كذا بسير أشوف
+
+756
+01:12:25,180 --> 01:12:30,180
+أنا فيه اختلافات بين الترتيب اللي هي القواعد
+
+757
+01:12:30,180 --> 01:12:36,000
+النيتروجينية في الـ DNA اللي ممكن تكون سبب في تغير
+
+758
+01:12:36,520 --> 01:12:42,320
+الصفات تبعات الـ «بروتين» والصفات اللي فاهرة على
+
+759
+01:12:42,320 --> 01:12:48,960
+الإنسان بعدين دكتور، في نقطة تانية إنه هل يمكن
+
+760
+01:12:48,960 --> 01:12:54,980
+افتراض إن غالبية اللي هو الـ «جينوم» يعني مثلا ما
+
+761
+01:12:54,980 --> 01:12:58,280
+بين الـReference وما بين individual one يعني بشكل
+
+762
+01:12:58,280 --> 01:13:03,730
+عشوائي، إنه هل هيكون غالبية الـ«جينوم» متشابه؟لكن
+
+763
+01:13:03,730 --> 01:13:08,110
+في اختلاف في 1% أو 2% يعني الغالب هو المتشابه
+
+764
+01:13:08,110 --> 01:13:11,690
+والاختلاف هو اللي هيكون أقل لإنه في الـ «سلايد»
+
+765
+01:13:11,690 --> 01:13:15,670
+يعني برضه في التعليق الـ «Catching» تحت الصورة
+
+766
+01:13:15,670 --> 01:13:20,630
+كاتب إن الـ «سيكوينس» من DNA من مجموعة من الشخصيات
+
+767
+01:13:20,630 --> 01:13:24,130
+هي متشابهة لكنها ليست متشابهة يعني الغالب هو اللي
+
+768
+01:13:24,130 --> 01:13:27,890
+يكون متشابه – هذه النقطة اللي بتحكيها طبعا يعني
+
+769
+01:13:27,890 --> 01:13:37,330
+هذا لتسهيل عملية دراسةالقطع المحددة يعني أنا بصير
+
+770
+01:13:37,330 --> 01:13:41,710
+مثلًا الواحد عنده hemoglobinopathy بصير بيدركز على
+
+771
+01:13:41,710 --> 01:13:46,350
+الـ الـ hemoglobin genes الـ Alpha والـ Beta
+
+772
+01:13:46,350 --> 01:13:51,530
+chains فبروح على الـ DNA تبعهم بحاول أسوي sequence
+
+773
+01:13:51,530 --> 01:13:55,850
+و بشوف مين إنسان مريض مين إنسان طبيعي بس حتى
+
+774
+01:13:55,850 --> 01:14:03,230
+أحيانًا الطبيعيين لما أنا أدرس الـ الـبالفرق بين
+
+775
+01:14:03,230 --> 01:14:06,550
+الـ Reference Sequence اللي هي ما هو عشان أقدر
+
+776
+01:14:06,550 --> 01:14:11,830
+يعني الـ Reference Sequence بالأخير بيمثل شو بده
+
+777
+01:14:11,830 --> 01:14:16,490
+أسميه يعني خارطة الطريق عشان تعرف وان أنت موجود
+
+778
+01:14:16,490 --> 01:14:25,310
+شايف علي؟ ضمن كمية الـ DNA هذه فترتيب الأحرف هذولة
+
+779
+01:14:25,310 --> 01:14:32,730
+هو اللي يعني بيمثل أحيان كثيرة قليةبتمكننا للوصول
+
+780
+01:14:32,730 --> 01:14:36,810
+لهذا الموقع فما علي إلى إفادات بس الفكرة اللي بدك
+
+781
+01:14:36,810 --> 01:14:42,370
+تاخدها إنه مش كل إنسان ما عدا الـ Identical Twins
+
+782
+01:14:42,370 --> 01:14:50,710
+ماشي الـ Identical Twins أه اللي بيكونوا شخصين
+
+783
+01:14:50,710 --> 01:14:57,910
+Completely Exact أي شخصين آخرين غير ذلك لما تيجي
+
+784
+01:14:57,910 --> 01:15:02,250
+تقارن بين الـ DNA تبعهمبكون فيه اختلافات،
+
+785
+01:15:02,250 --> 01:15:06,990
+واختلافات أحيانًا مش مهمة، يعني مالهاش تأثير وظيفي
+
+786
+01:15:06,990 --> 01:15:11,670
+على الـ Protein، وأحيانًا بتكون زي الـ Deletion،
+
+787
+01:15:11,670 --> 01:15:16,230
+لو الـ Deletion لثلاثة، بكون مش مهم كتير، بس لما
+
+788
+01:15:16,230 --> 01:15:20,610
+يكون واحد ولا أثنين، بيسموه Frame Shift، يعني
+
+789
+01:15:20,610 --> 01:15:25,450
+بيخربطلك الترتيب كله، فبالتالي، بكون تأثيره شديد
+
+790
+01:15:25,450 --> 01:15:30,320
+كتير أحيانًا، راح ناخد أن الظواهر هذه،أنا ما نوقفش
+
+791
+01:15:30,320 --> 01:15:36,000
+كثير كثير، يعني فيه لأي قطعة الـ DNA لما تتكلم
+
+792
+01:15:36,000 --> 01:15:41,060
+على، يعني هو إحنا مش بناخد التسع مليارات وباجي،
+
+793
+01:15:41,060 --> 01:15:44,140
+بدي أقول واحد بالمية، إثنين بالمية، فرق ولا كده،
+
+794
+01:15:44,140 --> 01:15:47,980
+إحنا لما نيجي ندرس في الـ Genetics، بالأخير بدي
+
+795
+01:15:47,980 --> 01:15:51,720
+أاخد قطعة صغيرة، بدي أاخد القطعة اللي عند الـ
+
+796
+01:15:51,720 --> 01:15:55,910
+Protein اللي أنا مهتم فيه، اللي أنا بدرسهللظاهر
+
+797
+01:15:55,910 --> 01:15:58,610
+اللي عندي، يا عم واحد عنده Hemoglobinopathy بدي
+
+798
+01:15:58,610 --> 01:16:01,330
+تبقى الـ Hemoglobin ألف أو Beta Chain، بركز على
+
+799
+01:16:01,330 --> 01:16:06,310
+هذولة لما أنا آجي أدرس كظاهرة في Reference بتكون
+
+800
+01:16:06,310 --> 01:16:10,310
+برجع لقطع معينة بيعتبروها هي الـReference،
+
+801
+01:16:10,310 --> 01:16:14,450
+Sequence وبلاقي أن البشر لما أنا آجي أدرسهم في
+
+802
+01:16:14,450 --> 01:16:18,910
+الغالب راح يكون فيه أنواع مختلفة من الاختلافات ما
+
+803
+01:16:18,910 --> 01:16:23,230
+عدا إذا Identical Twin للـReference إذا هو فعلاً
+
+804
+01:16:23,640 --> 01:16:31,040
+قريبه تمامًا، راح يكون تمامًا مثله، ماشي في أسئلة،
+
+805
+01:16:31,040 --> 01:16:38,940
+أنا مضطر أوقف هنا ساعة قريبة العشرة أشوف
+
+806
+01:16:38,940 --> 01:16:49,320
+إذا نلحق، نتكلم، هنا يعني اللي عندنا
+
+807
+01:16:49,320 --> 01:16:57,300
+حوالي 22 زوج أتزاملوفي عندي الـ X والـ Y الزوج تبع
+
+808
+01:16:57,300 --> 01:17:03,860
+الـ Six Chromosomes فلمّا نيجي نشوف صورتهم، هدولة
+
+809
+01:17:03,860 --> 01:17:08,160
+اللي هي الـ Karyotype بكون هيك أحجام الخلايا وهذا
+
+810
+01:17:08,160 --> 01:17:11,500
+بحطه جسم الستين بعضها باخد الستين أكتر على الـ
+
+811
+01:17:11,500 --> 01:17:21,040
+Histones وأشياء أقل، فيعني هنا مقارنة بينعدد
+
+812
+01:17:21,040 --> 01:17:27,560
+الكروموزومات لحجم الكروموزومات و الـ… الـDensity
+
+813
+01:17:27,560 --> 01:17:35,280
+تبعات الجينة يعني الـ25 ألف جين يعني
+
+814
+01:17:35,280 --> 01:17:43,180
+هاي هنا ألفين جين يعني اللي هو الـChromosome 1فيه
+
+815
+01:17:43,180 --> 01:17:49,540
+حوالي ألفين جين والأشياء زي الـ X والـ Y الـ Y
+
+816
+01:17:49,540 --> 01:17:57,940
+قصدي والـ Fair 21 و 22 أصغر جينات، أصغر كروموزومات
+
+817
+01:17:57,940 --> 01:18:02,840
+يكون عدد الجينات، بس بالمتوسط بيحكوا فيه حوالي ألف
+
+818
+01:18:02,840 --> 01:18:04,840
+جين في كل كروموزوم
+
+819
+01:18:07,650 --> 01:18:11,750
+فيعني هو أنا بالأخير باعتبروها هذا الخط أنه
+
+820
+01:18:11,750 --> 01:18:18,610
+تقريبًا ست يعني سبعة تقريبًا جينات في كل Mega Base
+
+821
+01:18:18,610 --> 01:18:23,950
+اللي هو يعني مليون Base يعني كل مليون Nucleotide
+
+822
+01:18:23,950 --> 01:18:29,970
+بعطيني تقريبًا سبع جينات، هيك يعني بدا نخطأ فكل ما
+
+823
+01:18:29,970 --> 01:18:33,890
+كان حجم الـChromosome أكبر، عدد الجينات اللي فيه
+
+824
+01:18:33,890 --> 01:18:39,180
+أكبرهي أسئلة أنا مضطر أوقف بنكمل من هيك للمرة
+
+825
+01:18:39,180 --> 01:18:45,350
+الجايةتمام، دكتور، بس برضه يعني هو سؤال يعني هو
+
+826
+01:18:45,350 --> 01:18:50,170
+تقريبًا بيتعلق بالـslide اللي قبل دكتور أسمى إنه
+
+827
+01:18:50,170 --> 01:18:53,910
+الـsequence هو سؤال الـsequence هذا بيكون لشخص
+
+828
+01:18:53,910 --> 01:18:57,450
+جيناته مثالي تقريبًا يعني بيصنع البروتينات بشكل
+
+829
+01:18:57,450 --> 01:19:01,470
+سليم وأي اختلاف هيكون واحد بالمية ممكن الاختلاف
+
+830
+01:19:01,470 --> 01:19:05,570
+يكون طفرة أو تباين بالصفرات لأ لأ، حسنًا خلّينا ما
+
+831
+01:19:05,570 --> 01:19:10,720
+تدخلوش بهذا الموضوع مش مقصود هذا الكلامالفكرة كانت
+
+832
+01:19:10,720 --> 01:19:18,980
+تالية، لما بعد ما اكتشفنا الـ DNA وصرنا نعرف عنه،
+
+833
+01:19:18,980 --> 01:19:25,760
+الكلام قبل تقريبًا 30 سنة، ماشي، كيف بدنا نحاول
+
+834
+01:19:25,760 --> 01:19:30,980
+نفهم هذا الموضوع، على أي أساس بدي أنا أقيم عموم
+
+835
+01:19:30,980 --> 01:19:38,660
+البشر، فلما نسوي الـ Human Genome Project،كانت إنه
+
+836
+01:19:38,660 --> 01:19:43,380
+أخذوا بني آدم أي إنسان أنا بقولولي كان واحد يعني
+
+837
+01:19:43,380 --> 01:19:48,140
+حضرت course أو محاضر عن الموضوع هذا وذكر ليه إنه
+
+838
+01:19:48,140 --> 01:19:53,500
+هم هذا شخص مجهول يعني هم مش محددينه بس الأصل إنه
+
+839
+01:19:53,500 --> 01:19:57,720
+شخص طبيعي بس كل إنسان طبيعي إلا عنده أمراض وراثية
+
+840
+01:19:57,720 --> 01:20:01,720
+وإلا عنده مشاكل هو مش مش مش طبيعي هو يعني ما تقدر
+
+841
+01:20:01,720 --> 01:20:07,570
+تعتبره طبيعي فأخذوا بني آدم إيه؟ شخصوقروا كل شيء
+
+842
+01:20:07,570 --> 01:20:14,530
+عنده فلما قرناهن كلهن أصبحت هذه هي الـ Reference
+
+843
+01:20:14,530 --> 01:20:19,490
+Sequence فسير لما أنا آجي أتعامل مع أي حال بعدين
+
+844
+01:20:19,490 --> 01:20:24,730
+فسير أقول بالرجوع إلى حالة الشخص اللي هو الـ Human
+
+845
+01:20:24,730 --> 01:20:28,150
+Genome ما هو الـ Human Genome أنه أنا قريت تبعت
+
+846
+01:20:28,150 --> 01:20:32,870
+بني آدم تسع مليارات الـ Nucleotides وقريت شو هن
+
+847
+01:20:33,560 --> 01:20:36,780
+فهذه حتى محفوظة وموجودة يقول اللي بده يرجعلها
+
+848
+01:20:36,780 --> 01:20:42,120
+يرجعلها فلما أنا أجي أخد مثلا بعدين في هذه القطعة
+
+849
+01:20:42,120 --> 01:20:46,560
+الصغيرة اللي هى هدولة مثلا أربعين الـ Nucleotide
+
+850
+01:20:46,560 --> 01:20:54,640
+جبت الإنسان ألف في دراسة عيلة معينة نفترض فالشخص
+
+851
+01:20:54,640 --> 01:20:59,820
+الأول في العيلة والله طلع مطابق تماما لهذا المرجع
+
+852
+01:21:00,860 --> 01:21:05,320
+الشخص الثاني والثالث طلع فيه Single-neutralized
+
+853
+01:21:05,320 --> 01:21:10,160
+polymorphism أو Changes يعني في محل واحد فالشخص
+
+854
+01:21:10,160 --> 01:21:14,220
+الثاني والثالث والرابع الشخص الخامس الانهي هي
+
+855
+01:21:14,220 --> 01:21:21,100
+طريقة الـ Reporting يعني طريقة تقرير أو شو اللي
+
+856
+01:21:21,100 --> 01:21:26,240
+أنا راح اكتبه لما درست تبع الـ DNA تبع عائلة معينة
+
+857
+01:21:26,240 --> 01:21:33,020
+أو مجموعة معينة أو شخص معين فالآنالـ… يعني
+
+858
+01:21:33,020 --> 01:21:40,180
+الـReference لا يمثل الطبيعي بس يمثل المرجعية اللي
+
+859
+01:21:40,180 --> 01:21:47,260
+بدرسه الـGenetics وبدرسه الـ… الـ… يعني بدرسه
+
+860
+01:21:47,260 --> 01:21:51,420
+الموضوع هذا الـ… الـGenetics تبعت أي مرض، تبعت أي
+
+861
+01:21:51,420 --> 01:21:55,660
+عيلة، تبعت أي مشكلة، بيصيروا يقارنوا فيه، فهو
+
+862
+01:21:55,660 --> 01:22:01,680
+مرجعية لإنكيعني تحكي شو النتيجة في الدراسة اللي
+
+863
+01:22:01,680 --> 01:22:06,800
+انت القيتها فاهم عليك؟ فلا تمثل أنه بالضرورة
+
+864
+01:22:06,800 --> 01:22:11,180
+reference هو الطبيعي و individual one طبيعي واثنين
+
+865
+01:22:11,180 --> 01:22:15,600
+وثلاثة هم مريضين، لأ، في الغالب مش مريضين، بس هي
+
+866
+01:22:15,600 --> 01:22:20,610
+ظاهرة موجودةماشي ورح نحكي ليش مش بالضرورة يكون أنه
+
+867
+01:22:20,610 --> 01:22:24,090
+هذا يغير البروتين يعني ممكن individuals one و two
+
+868
+01:22:24,090 --> 01:22:27,770
+و three و four يطلع نفس البروتين مايكونش فرق بينهم
+
+869
+01:22:27,770 --> 01:22:37,270
+حتى لو ال DNA اختلف واضح؟
+
+870
+01:22:37,270 --> 01:22:41,790
+أتمنى أنه يكون الأمر واضح إذا في حد عنده سؤال تمام
+
+871
+01:22:42,630 --> 01:22:47,770
+أنا عندى ساعة عشرة محاضرة ثانية أو شغل فنلتقي يوم
+
+872
+01:22:47,770 --> 01:22:51,450
+الأحد إن شاء الله الساعة تمانية ونصف ونفدى من هنا
+
+873
+01:22:51,450 --> 01:22:59,530
+واللي عنده أي سؤال إذا بالـ WhatsApp فى إشي أو إذا
+
+874
+01:22:59,530 --> 01:23:03,910
+group بيكون موجودة و بتقدر تدخلنى فيهم ممكن من هنا
+
+875
+01:23:03,910 --> 01:23:08,160
+إلى ذلك الوقت نتكلم على هذاطلعنا من المعدين
+
+876
+01:23:08,160 --> 01:23:11,980
+المندوين أسف إنه يعملوا group WhatsApp و تكون أنت
+
+877
+01:23:11,980 --> 01:23:17,400
+موجود فيه مافي مشكلة، مافي مشكلة إذا .. إذا في أي
+
+878
+01:23:17,400 --> 01:23:21,780
+أسئلة مش واضح نتكلم عليه إن شاء الله بإذن الله
+
+879
+01:23:21,780 --> 01:23:24,740
+تعالى أهلين، أهلين، يالا السلام عليكم يعطيك
+
+880
+01:23:24,740 --> 01:23:27,320
+العافية دكتور الله يرضي عليكم، نشوفكم على خير إن
+
+881
+01:23:27,320 --> 01:23:30,580
+شاء الله مع السلامة مع السلامة
+
+882
+01:23:34,350 --> 01:23:37,330
+أعطيكم العافية برضه دكاترا في العاية التالية
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/Y-q_VMv635w.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/Y-q_VMv635w.srt
new file mode 100644
index 0000000000000000000000000000000000000000..e40967733d2b4e95e4d7dc254672bbe3690c7c58
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/Y-q_VMv635w.srt
@@ -0,0 +1,2708 @@
+1
+00:00:00,000 --> 00:00:04,820
+الذين يتعاملون بـ Minor Trauma والذين والدته ليس
+
+2
+00:00:04,820 --> 00:00:12,620
+لديه مشكلة برده، طبعا يعني اللي لما نكون عندنا شيء
+
+3
+00:00:12,620 --> 00:00:20,320
+بنقوله يعني bleeding tendency فهي مشكلة في الـ
+
+4
+00:00:20,320 --> 00:00:27,280
+bleeding disorder،  بنسميها أو problem with
+
+5
+00:00:27,280 --> 00:00:32,840
+الـ Hemostasis، يعني اللي هي طريقة
+
+6
+00:00:32,840 --> 00:00:37,280
+استجابة الجهاز الدوري، الـ Cardiovascular System
+
+7
+00:00:37,280 --> 00:00:44,820
+لموضوع الـ Injury، موضوع حدوث تمزق في الأوعية
+
+8
+00:00:44,820 --> 00:00:49,500
+الدموية، في حياته الدم بيصير يطلع، فعندنا نوعين من الـ
+
+9
+00:00:49,500 --> 00:00:53,820
+Hemostasis، فيه Primary Hemostasis وفيه Secondary
+
+10
+00:00:53,820 --> 00:01:00,430
+Hemostasis، الـ Primary اللي بيشتغل أولاً مباشرة، ماشي
+
+11
+00:01:00,430 --> 00:01:06,490
+وبكون واحدة من إثنتين: الـ platelets أو الـ blood
+
+12
+00:01:06,490 --> 00:01:11,110
+vessel response، فهدول بيسموها primary hemostasis
+
+13
+00:01:11,110 --> 00:01:17,850
+أما الـ secondary hemostasis اللي هم نتيجة شغل الـ
+
+14
+00:01:17,850 --> 00:01:22,430
+coagulation factor، في عندنا الـ Extrinsic Pathway و
+
+15
+00:01:22,430 --> 00:01:25,810
+Intrinsic Pathway وCommon Pathway في الأخير
+
+16
+00:01:25,810 --> 00:01:29,750
+الفيبرينوجين بتحول لفيبرين، بأعمل Clot، بسكر الـ
+
+17
+00:01:29,750 --> 00:01:33,810
+Blood، اللي انغلق، هدول الـ Primary وSecondary
+
+18
+00:01:33,810 --> 00:01:43,190
+Hemostasis، ليش حطيت لكم النقاط هذه؟ دائماً سامعيني؟
+
+19
+00:01:43,190 --> 00:01:46,930
+فاهميني معي الشباب والكل
+
+20
+00:01:51,290 --> 00:01:56,070
+- Hi كريم، معك؟ ‏- مرحبًا يا أختي، واصلِ ‏- طيب،
+
+21
+00:01:56,070 --> 00:02:01,850
+الآن كيف نفرق الـ Primary وSecondary Hemostasis؟ ‏
+
+22
+00:02:01,850 --> 00:02:04,910
+- هذه نقطة بالـ Hematology، المفروض تأخذوها بعدها
+
+23
+00:02:04,910 --> 00:02:10,630
+‏- لدينا أربع Characteristics نفرقها ‏- هل هي
+
+24
+00:02:10,630 --> 00:02:16,910
+Coagulation Factor Problem ‏- ولا الـ
+
+25
+00:02:16,910 --> 00:02:21,950
+Primary، يعني الـ Coagulation Factor ولا الـ Platelet
+
+26
+00:02:21,950 --> 00:02:25,130
+to Blood Vessel Response Problem، الـ Primary ولا
+
+27
+00:02:25,130 --> 00:02:29,210
+الـ Secondary، الـ Primary أول شيء بنقوله
+
+28
+00:02:29,210 --> 00:02:34,270
+Superficial، يعني علاجين على الإسنان لما واحد يفرش
+
+29
+00:02:34,270 --> 00:02:39,310
+أسنانه، لما يكون شيء بيكون سطحي، الـ Coagulation
+
+30
+00:02:39,310 --> 00:02:43,930
+Factor Problem بيكون Deep، يعني زي هيك في الـ Joint
+
+31
+00:02:43,930 --> 00:02:48,070
+لما يقول لك إنه في عنده Joint Problem، Joint Swelling
+
+32
+00:02:48,660 --> 00:02:51,720
+وBleeding in the joints، هذه بتقول Coagulation
+
+33
+00:02:51,720 --> 00:02:58,120
+Factor، هاي واحدة، الشغل الثاني، الـ Bleeding بعد الـ
+
+34
+00:02:58,120 --> 00:03:03,560
+trauma، في حالة الـ Primary Hemostasis بيكون
+
+35
+00:03:03,560 --> 00:03:07,460
+Immediate، لأنه Immediate، الـ Primary يعني لو واحد
+
+36
+00:03:07,460 --> 00:03:11,060
+يكون عنده Platelet ولا عنده Blood Vessel Response
+
+37
+00:03:11,060 --> 00:03:19,190
+Problem، بتلاقي مثلاً بنجرح على طول بينزل، إذا سكرنا
+
+38
+00:03:19,190 --> 00:03:22,850
+عليها ومنعنا النزف، وعطينا مجال للـ Coagulation
+
+39
+00:03:22,850 --> 00:03:29,650
+Factor يشتغل، في الحالة هذه لما تسكر على الجرح، لما
+
+40
+00:03:29,650 --> 00:03:33,490
+تشيل يدك بعدين النزف بيوقف، هذا بالـ Primary
+
+41
+00:03:33,490 --> 00:03:38,090
+Hemostasis، السبب إن الـ Coagulation Factor كويسة
+
+42
+00:03:38,090 --> 00:03:45,030
+بينما الـ Secondary Hemostasis بيكون بالأول الـ
+
+43
+00:03:45,030 --> 00:03:51,450
+Coagulation Factor، ماشي، يعني كثير قصص، أشهر واحد كان
+
+44
+00:03:51,450 --> 00:03:56,370
+عنده Hemophilia، لـ Coagulation Factor Problem، ابن
+
+45
+00:03:56,370 --> 00:04:00,390
+قيصر روسيا، كانت بالثورة البلشفية، كان عنده
+
+46
+00:04:00,390 --> 00:04:07,730
+Hemophilia، هو نفس هذه القصة، طفل ذكر كان يقع مثلاً
+
+47
+00:04:07,730 --> 00:04:13,010
+هو يلعب، مجرد ما يقع ما يكون فيه شيء، يعني يكون زي زي
+
+48
+00:04:13,010 --> 00:04:18,660
+غيره، بس بعد 6 ساعات، 8 ساعات، 10 ساعات بيصير يبين
+
+49
+00:04:18,660 --> 00:04:23,800
+Big Hematoma، فالـ onset of bleeding after trauma
+
+50
+00:04:23,800 --> 00:04:29,040
+is delayed for secondary hemostasis، ولما تيجي
+
+51
+00:04:29,040 --> 00:04:35,580
+تضغط على محل النزف وتضغط لك ربع ساعة، تلت ساعة،
+
+52
+00:04:35,580 --> 00:04:41,600
+نصف ساعة، لما تشيل يدك، لا النزف بيرجع، ما هو وقته
+
+53
+00:04:42,500 --> 00:04:47,600
+فهذه كلها secondary hemostasis problems، من ناحية
+
+54
+00:04:47,600 --> 00:04:54,300
+الأخيرة، اللي هي مبدأ إنه in general، إذا familial
+
+55
+00:04:54,300 --> 00:04:59,760
+أو genetic، الـprimary hemostasis problems بتكون
+
+56
+00:04:59,760 --> 00:05:05,660
+autosomal dominant، زي «بومبلبراند» disease والجروب
+
+57
+00:05:05,660 --> 00:05:10,420
+التابعة لها، هذه الـhemophilias، فيهم hemophilia A وB
+
+58
+00:05:10,940 --> 00:05:21,380
+بتكون X-linked Recessive، فالسيناريو
+
+59
+00:05:21,380 --> 00:05:26,200
+اللي حاطينه بالأول، طفل Male وعنده شكله Secondary
+
+60
+00:05:26,200 --> 00:05:31,700
+Hemostasis Problem، وهي كلها ماشي، مؤشر على
+
+61
+00:05:31,700 --> 00:05:35,810
+Hemophilia، طبعاً الـ Hemophilia فيه Hemophilia A و
+
+62
+00:05:35,810 --> 00:05:39,830
+Hemophilia B، الـ Hemophilia A اللي هو الـ Factor 8
+
+63
+00:05:39,830 --> 00:05:43,830
+Deficiency، Hemophilia B اللي هي Factor 9، اللي
+
+64
+00:05:43,830 --> 00:05:48,550
+بيسموها Christmas Disease، اللي هي اسم ثاني، كل هذه
+
+65
+00:05:48,550 --> 00:05:53,650
+المعلومات هيك بتيجي من الأول، يعني إنسان أو طفل أو
+
+66
+00:05:53,650 --> 00:06:00,050
+ذكر عنده Hemophilia A، هاي الكلام اللي بيبقوا له
+
+67
+00:06:00,050 --> 00:06:02,670
+يعني الآن
+
+68
+00:06:04,750 --> 00:06:08,530
+الـ evaluation shows that the patient has
+
+69
+00:06:08,530 --> 00:06:12,710
+inherited disorders، and that one of his parents is
+
+70
+00:06:12,710 --> 00:06:19,110
+a genetic carrier، طبعا يعني هنا، هاي لو كان
+
+71
+00:06:19,110 --> 00:06:26,510
+autosomal recessive، ما بتثبت، كان لازم يكون both
+
+72
+00:06:26,510 --> 00:06:32,650
+his parents are recessive are carriers، ماشي، هذه
+
+73
+00:06:32,650 --> 00:06:36,570
+إلا تكون X-linked recessive، والـ Carrier بالـ
+
+74
+00:06:36,570 --> 00:06:45,790
+Parents هي الأم، ماشي؟  أسا عنده أخت who does not
+
+75
+00:06:45,790 --> 00:06:53,290
+have this condition is pregnant، يعني أسا أخته يعني
+
+76
+00:06:53,290 --> 00:07:01,090
+الـ Hallmark دائماً بنقول أو العلامة المميزة للـ X
+
+77
+00:07:01,090 --> 00:07:08,790
+-linked recessive، أن الطفل أو أخواله هما المصابين،
+
+78
+00:07:08,790 --> 00:07:16,630
+ماشي؟ فيعني إذا بدك تشوف إنسان، إذا هو عنده زي
+
+79
+00:07:16,630 --> 00:07:21,130
+أخواله، إذا ولدوا أخواله، هي typical X-linked
+
+80
+00:07:21,130 --> 00:07:30,200
+recessive، فالآن الأخت حامل، أخت المصاب ماشي، هي اللي
+
+81
+00:07:30,200 --> 00:07:39,080
+جاي تسأل، وهي ما بتعرف اللي ببطنها ولد ولا بنت، ماشي
+
+82
+00:07:39,080 --> 00:07:43,100
+she asked about the risk of her child will be
+
+83
+00:07:43,100 --> 00:07:45,600
+affected، which of the following is the best
+
+84
+00:07:45,600 --> 00:07:52,400
+estimate of this child will have the disease، ماشي
+
+85
+00:07:52,400 --> 00:07:54,580
+الآن
+
+86
+00:07:57,040 --> 00:08:01,600
+يعني مبدأ في حل الأسئلة اللي زي هيك، أو في التعامل
+
+87
+00:08:01,600 --> 00:08:07,880
+مع هذا السؤال، لما يجيك من بني آدم، ماشي، بنحطه على
+
+88
+00:08:07,880 --> 00:08:14,800
+طريقين، اللي هم يا إما أنا بكون متأكد وعارف
+
+89
+00:08:14,800 --> 00:08:24,690
+وبالتالي بأعطِ نسب محددة، أو إذا مش متأكد، ماشي، بدي
+
+90
+00:08:24,690 --> 00:08:29,870
+أسوي اللي بيسموهم الـ Conditional Probability، واضح
+
+91
+00:08:29,870 --> 00:08:34,150
+يا كريم؟ الله يرضى عليك، سامعني؟ فاهميني إيه؟ شو
+
+92
+00:08:34,150 --> 00:08:39,550
+اللي بحكي؟ تمام يا دكتور، كل موجود يعني، أو في عدد
+
+93
+00:08:39,550 --> 00:08:43,050
+موجود، يعني غير كريم كمان موجودين، أه، كنا سبعة
+
+94
+00:08:43,050 --> 00:08:46,930
+اللي موجود أنا وياك، يعني خمسة غيره، أنا فاهم إن اللي
+
+95
+00:08:46,930 --> 00:08:52,070
+طرح السؤال يكون فاهمه، هو الدكتورة «كارميل» هي اللي
+
+96
+00:08:52,070 --> 00:08:58,890
+طرحت السؤال، يعني موجودة؟ صحيح، صحيح، صحيح، موجودة
+
+97
+00:08:58,890 --> 00:09:04,730
+طيب، هسا كارميل كيف
+
+98
+00:09:04,730 --> 00:09:14,070
+بدنا نرد على إجابة السؤال هذا؟ الآن أنا الـ
+
+99
+00:09:14,070 --> 00:09:16,810
+Genotype، يعني شو
+
+100
+00:09:19,740 --> 00:09:27,620
+الطفل المصاب أكيد عنده X-Chromosome مصاب، الـ X
+
+101
+00:09:27,620 --> 00:09:32,160
+-Chromosome عنده مصاب، الـ Y مافيش فيه شيء، صح؟
+
+102
+00:09:32,160 --> 00:09:38,600
+فبالتالي أخذه من يا أبوه يا أمه الـ X هذا، ماشي؟
+
+103
+00:09:39,110 --> 00:09:46,450
+لو كان أبوه، حكوا عنه مصاب يبقى ممكن أخذه منه، بس
+
+104
+00:09:46,450 --> 00:09:54,030
+الـ X بتكون من الـ، يعني في الحالة هذه بتكون من
+
+105
+00:09:54,030 --> 00:10:01,750
+الأم، والأم، أم الطفل هذا المصاب شو اسمه؟ هي الـ
+
+106
+00:10:01,750 --> 00:10:08,270
+Carrier، لأنهم إثنينهم Healthy والطفل هذا هو المصاب
+
+107
+00:10:08,810 --> 00:10:13,810
+فكيف بدأ أسوي الاحتمالات للسؤال اللي بيسألونِياه؟
+
+108
+00:10:13,810 --> 00:10:20,390
+أخت الطفل هذا الأكبر منه صارت حامل، وشافت أخوها
+
+109
+00:10:20,390 --> 00:10:26,670
+عنده مشكلة الـ hemophilia، وإنه بينزل وإنه في عنده
+
+110
+00:10:26,670 --> 00:10:30,770
+مشاكل، فخائفة على بطنها أو بدأت تتأكد بالنسبة
+
+111
+00:10:30,770 --> 00:10:41,860
+لبطنها، شو احتمالاته؟ ماشي، الـ ... الـ ... هذه ما يسمى
+
+112
+00:10:41,860 --> 00:10:45,020
+النسب
+
+113
+00:10:45,020 --> 00:10:48,800
+اللي حاطينها، عشر أو ثمانية أو تسعة أو عشرين، أنا
+
+114
+00:10:48,800 --> 00:10:53,980
+هذه خربطتني شوية، هذه نسبة اللي جاوبوا هيك، ماشي
+
+115
+00:10:53,980 --> 00:10:59,300
+ما بدي أدخل فيها، هو أنا بحط النسبة صفر أو نصف أو
+
+116
+00:10:59,300 --> 00:11:02,460
+ربع أو ثمن أو سدس، واحد أو ستة عشر أو واحد أو اثنين
+
+117
+00:11:02,460 --> 00:11:10,410
+وثلاثين، كيف بدنا نقولها؟ الآن السؤال الأول، الأم اللي
+
+118
+00:11:10,410 --> 00:11:19,910
+هي البنت اللي هي حامل الآن، اللي جاي تسأل، «ماشي، شو
+
+119
+00:11:19,910 --> 00:11:25,270
+احتمالاتها بالنسبة للمرض هذا؟» «والحالي هذا؟» «مين
+
+120
+00:11:25,270 --> 00:11:34,190
+بيقدر يجاوب؟» قبل ما نشوف كيف جاوبتها، يا
+
+121
+00:11:34,190 --> 00:11:39,620
+إما هتكون healthy يا إما هتكون carrier، النسبة كم لكل
+
+122
+00:11:39,620 --> 00:11:51,100
+واحدة؟ ربع، طبعاً، كيف ربع؟ نصف، المشومة للأم الأصلية
+
+123
+00:11:51,100 --> 00:11:55,340
+carrier، والأب healthy، طيب، ماني أعمل احتمالات،
+
+124
+00:11:55,340 --> 00:12:00,100
+هيُطلع؟ أنا بحكي عن البنت اللي حامل اللي هي الآن، لو
+
+125
+00:12:00,100 --> 00:12:05,500
+ترسم الـ degree، هي اللي جاية تسأل وعندها pregnancy
+
+126
+00:12:05,500 --> 00:12:11,550
+هي الأم، المرأة الحامل، هسا، شو احتمالات عندها الجين
+
+127
+00:12:11,550 --> 00:12:19,890
+المصاب؟ نصف الإناث، نصف بتكون، نصف، يعني نصف الحالة، شو
+
+128
+00:12:19,890 --> 00:12:28,630
+اسمها؟ نصف الحالة بكون فيها، عندها إصابة، آسف، نصف
+
+129
+00:12:28,630 --> 00:12:33,250
+الحالات بتكون هي carrier، ونصف الحالات ممكن تكون
+
+130
+00:12:33,250 --> 00:12:40,820
+completely healthy، صح؟ تمام، صحيح، كم احتمالات أن
+
+131
+00:12:40,820 --> 00:12:50,480
+البطنها ولد ولا بنت؟ كمان نصف، بنصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف،
+
+132
+00:12:50,480 --> 00:12:51,520
+نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف،
+
+133
+00:12:51,520 --> 00:12:52,820
+نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف،
+
+134
+00:12:52,820 --> 00:12:55,440
+نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف،
+
+135
+00:12:55,440 --> 00:12:59,440
+نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف،
+
+136
+00:12:59,440 --> 00:12:59,520
+نصف، نصف، نصف، نصف، نصف، نصف، نصف، نصف،
+
+137
+00:13:08,490 --> 00:13:16,030
+الحمل اللي بطن المرأة هذه أو البنت هذه، نصف، نصف إنها
+
+138
+00:13:16,030 --> 00:13:20,150
+تكون مصابة، مصابة؟ ما أعرفش، احتمال إنها تكون مصابة
+
+139
+00:13:20,150 --> 00:13:28,470
+لأنه فيه احتمال نصف إنه تكون carrier، ماشي، ونصف ثاني
+
+140
+00:13:28,470 --> 00:13:33,990
+إنه، لأنه ما جاب سيرته، إنه، الجوز المرة هذه، أو الطفل
+
+141
+00:13:33,990 --> 00:13:40,950
+البنت هذه اللي، يعني أخت المصاب، ما جابه سيرة إنه
+
+142
+00:13:40,950 --> 00:13:47,550
+مصاب كمان، صحيح، فهسا لو كانت بنت، فاحتمالية إنها
+
+143
+00:13:47,550 --> 00:13:56,070
+تكون مصابة صفر، صح؟ ولو طلع ولد، شو نسبته إنه يكون
+
+144
+00:13:56,070 --> 00:14:04,270
+مصاب؟ أخذ الـ X المصاب، يعني نصف، برضه، نصف، نصف، صح؟ صحيح
+
+145
+00:14:04,270 --> 00:14:13,210
+فإن أنت تأخذ إنه هي كالبنت
+
+146
+00:14:13,210 --> 00:14:19,470
+العامل هذه، أخت الولد المصاب، أول شيء، هي احتمالها نصف
+
+147
+00:14:19,470 --> 00:14:26,470
+إنه تكون هي carrier، أي واحدة يعني عندها one copy، وفي
+
+148
+00:14:26,470 --> 00:14:31,650
+احتمال نصف أن يكون بنت، وبالتالي ما في احتمال أن
+
+149
+00:14:31,650 --> 00:14:37,830
+يكون مصاب، ولو كان ولد، الاحتمال نصف، فنصف بنصف بنصف بنصف
+
+150
+00:14:37,830 --> 00:14:45,450
+بيطلع ثمن، فالإجابة ثمن، واضحة، يعني هنا بدنا نطبق
+
+151
+00:14:45,450 --> 00:14:51,530
+شيء من كلّه، conditional probability، ماشي، بقول الـ
+
+152
+00:14:54,060 --> 00:15:00,900
+اللي هي المرأة الحامل هذه، الأم اللي هنا بالحالة
+
+153
+00:15:00,900 --> 00:15:07,300
+الجيل الثاني، أخت المصاب، أول شيء في احتمال نصف أنه
+
+154
+00:15:07,300 --> 00:15:13,100
+تكون carrier، ونصف أنها تكون normal، وبعدين احتمال أنه
+
+155
+00:15:13,100 --> 00:15:19,940
+يكون ذكر ولا أنثى، اللي بطنها، ما بنعرف لسه، لو
+
+156
+00:15:19,940 --> 00:15:25,080
+بعرف أنه ذكر، بقول لأ، الاحتمال بصير ربع، ماشي، لو
+
+157
+00:15:25,080 --> 00:15:29,260
+بعرف أنه ذكر، بس أنا ما بعرف إنه ذكر، فيمكن ذكر،
+
+158
+00:15:29,260 --> 00:15:32,660
+يمكن أنثى، لو هيك بتيجي بتسألني بالوجه، شو
+
+159
+00:15:32,660 --> 00:15:36,620
+احتمالية أنه يكون مصاب، بقول واحد على ثمانية،
+
+160
+00:15:36,620 --> 00:15:39,380
+واضحة الحال كيف؟ اللي بيسموها conditional
+
+161
+00:15:39,380 --> 00:15:46,370
+probability، يعني أنا بصير أحسب الشروط، مجموع
+
+162
+00:15:46,370 --> 00:15:51,990
+الاحتمالات، مجموع النسب لازم يوصل واحد، لأن كل
+
+163
+00:15:51,990 --> 00:15:58,630
+الاحتمالات راح تكون واحد، ماشي؟ فلما تيجيني امرأة
+
+164
+00:15:58,630 --> 00:16:03,230
+هيك زي هيك، أخوها مصاب، هي حامل، هي مش عارفة شو
+
+165
+00:16:03,230 --> 00:16:06,830
+اللي عندها، بتقول لي شو نسبة احتمالية أن البطن يطلع
+
+166
+00:16:06,830 --> 00:16:11,650
+مصاب، بقول لها واحد على ثمانية، هيك بدها تيجي، ماشي؟
+
+167
+00:16:12,100 --> 00:16:18,160
+فنشوف شو الـ ... الـ ... هنا هذا السؤال، يعني فيه ناس
+
+168
+00:16:18,160 --> 00:16:23,060
+خربطوا في الربع، فيه ناس حطوا نصف، فهسا هنا يعني هاي
+
+169
+00:16:23,060 --> 00:16:31,040
+برسم لنا المثال اللي إحنا اتكلمنا عنه، الـ ... هاي
+
+170
+00:16:31,040 --> 00:16:39,420
+الجدود، الأم أكيد لازم تكون carrier، الأب حكوا عنه
+
+171
+00:16:39,420 --> 00:16:49,370
+سليم، مافيش مشكلة، الولد المصاب عنده جين مصاب، ماشي، في
+
+172
+00:16:49,370 --> 00:16:54,950
+الـ X، و X-linked recessive، فهي ببين عليه، فهذه البنت
+
+173
+00:1
+
+223
+00:22:02,610 --> 00:22:07,970
+الـ «square root» للـ 40 ألف هذا وبيطلع واحد على
+
+224
+00:22:07,970 --> 00:22:14,210
+ميتين، واحد على ميتين، تمام، ماشي، فيعني هسه في
+
+225
+00:22:14,210 --> 00:22:25,890
+معلومات أخذناها، القصة اللي بيحكوها هنا أن الزلمة
+
+226
+00:22:25,890 --> 00:22:32,310
+يعني هدول الـ couple، هدول الزوجين، عملوا شغل بدهم
+
+227
+00:22:32,310 --> 00:22:40,870
+يخلفوا، الزلمة ما فيش endosperm وبيخلفش، فراحت هي مع
+
+228
+00:22:40,870 --> 00:22:46,370
+زوجها، راحوا على تبعين اللي بيعملوا اللي هو التلقيح
+
+229
+00:22:46,370 --> 00:22:51,150
+بالأنبوب، أو زراعة أنبوب للأطفال، لزراعة الأطفال
+
+230
+00:22:51,150 --> 00:22:58,150
+بالأنبوب، وأخذت حيوان منوي من أي واحد من الـ
+
+231
+00:22:58,150 --> 00:23:05,310
+general population، السائلين، وأنجبت الطفل اللي ولدته
+
+232
+00:23:05,310 --> 00:23:10,910
+بهذه الطريقة، عنده هذه الإصابة، المرض النادر هذا طلع
+
+233
+00:23:10,910 --> 00:23:17,680
+الطفل المصاب، ماشي، فهذه قصتها، Genetic
+
+234
+00:23:17,680 --> 00:23:21,660
+Testing Confirms That The Patient Is A Carrier For
+
+235
+00:23:21,660 --> 00:23:27,460
+The Disease، طلعت الجين المصاب هو في الـ.. كنسبة
+
+236
+00:23:27,460 --> 00:23:34,480
+الأليل في الـ population واحد على ميتين، فالإصابة
+
+237
+00:23:34,480 --> 00:23:40,680
+بتكون واحد في الأربعين ألف، اللي هي Q تربيع، ماشي
+
+238
+00:23:42,480 --> 00:23:50,600
+الآن، ماذا ستفعل؟ هي Carrier، فإنه
+
+239
+00:23:50,600 --> 00:23:57,860
+الأول طلع بهذا الشكل، معناته إنه نصيبهم، إن الشخص
+
+240
+00:23:57,860 --> 00:24:03,280
+الثاني اللي أخذوا منه بشكل عمياني
+
+241
+00:24:03,280 --> 00:24:11,270
+الـ Spare، طلع عنده الـ Carrier للجين هذا، وبالتالي
+
+242
+00:24:11,270 --> 00:24:14,330
+autosome-recessive، فواحد من هذا الـ 40 ألف طلع
+
+243
+00:24:14,330 --> 00:24:18,950
+بهذا الطفل، اللي عنده بالأول، a different sperm
+
+244
+00:24:18,950 --> 00:24:22,770
+donor is selected with no personal or family
+
+245
+00:24:22,770 --> 00:24:27,210
+history of Bombay disease, however his carrier
+
+246
+00:24:27,210 --> 00:24:31,550
+status is unknown، فقرروا المرة الثانية بيعدوا نفس
+
+247
+00:24:31,550 --> 00:24:36,330
+الشغل، بس المرة هذه قالوا خلينا ناخد حد ثاني، فاخذوا
+
+248
+00:24:36,330 --> 00:24:41,790
+شخص آخر، بس برضه مش قادرين يكونوا متأكدين إنه ما
+
+249
+00:24:41,790 --> 00:24:45,510
+عنده المرض، وفي الغالب اللي بتبرع بهذه الشغلات يكون
+
+250
+00:24:45,510 --> 00:24:49,830
+يفترض إنه هيك، على الأقل مظهريًا، إنه إنسان سليم
+
+251
+00:24:49,830 --> 00:24:57,990
+وطبيعي، وكذا، وكذلك، يعني، ماشي؟ So، الآن السؤال، What
+
+252
+00:24:57,990 --> 00:25:02,350
+is the probability of the patient having an
+
+253
+00:25:02,350 --> 00:25:10,500
+affected child with the new sperm donor؟ الآن الأم
+
+254
+00:25:10,500 --> 00:25:19,100
+اللي هي هاي، بتسأل، هي أكيد إيش؟ مصابة، ولا carrier
+
+255
+00:25:19,100 --> 00:25:24,960
+ولا طبيعي؟ - carrier - لازم تكون carrier، صح؟ -
+
+256
+00:25:24,960 --> 00:25:29,020
+لازم تكون carrier - لازم تكون carrier - لازم تكون
+
+257
+00:25:29,020 --> 00:25:30,620
+carrier - لازم تكون carrier - لازم تكون carrier -
+
+258
+00:25:30,620 --> 00:25:30,800
+لازم تكون carrier - لازم تكون carrier - لازم تكون
+
+259
+00:25:30,800 --> 00:25:30,840
+carrier - لازم تكون carrier - لازم تكون carrier -
+
+260
+00:25:30,840 --> 00:25:35,160
+carrier - لازم تكون carrier -
+
+261
+00:25:38,190 --> 00:25:42,610
+مش لسه بدي أدرس، أو كده، لأنه هذا autism and
+
+262
+00:25:42,610 --> 00:25:48,830
+recessive، وفيه طفل مصاب، إذن الأم والأب الحقيقي
+
+263
+00:25:48,830 --> 00:25:52,730
+اثنينهم لازم يكونوا carrier، ما بيصير، يعني ما راح
+
+264
+00:25:52,730 --> 00:25:58,170
+يطلع autism and recessive وما فيش carrier، يعني، أو
+
+265
+00:25:58,170 --> 00:26:02,310
+واحد بس اللي carrier، لازم اثنين carrier، فالآن
+
+266
+00:26:02,310 --> 00:26:05,510
+الحكي
+
+267
+00:26:05,510 --> 00:26:13,900
+الأم، شو احتمالية إنها تعطي الجين، الأليل المصاب؟ هي
+
+268
+00:26:13,900 --> 00:26:22,880
+carrier، إذا الاحتمال إيش؟ نصف، وجابوا sperm جديد من
+
+269
+00:26:22,880 --> 00:26:27,500
+الـ general population، فشو احتمالية إنه يكون حامل
+
+270
+00:26:27,500 --> 00:26:34,640
+للجين تبع المرض؟ اللي هي الـ Q اللي طلعناها من الـ Q
+
+271
+00:26:34,640 --> 00:26:40,550
+تربيع، اللي معطيني إياها، هو الـ Spare Donor مش راح يكون
+
+272
+00:26:40,550 --> 00:26:44,870
+affected، لإنه كان لك حينورمال في 2020 –شو احتمالية
+
+273
+00:26:44,870 --> 00:26:53,730
+إن الـ Spare Donor يطلع carrier، أو قداش الاحتمالية
+
+274
+00:26:53,730 --> 00:26:58,030
+1 على 200، لأن هذا احتمالية –إن السنة كانت من الـ Q تربيع– نعم
+
+275
+00:26:58,030 --> 00:26:59,170
+–نعم
+
+276
+00:27:10,530 --> 00:27:13,690
+الـ Spare، بما أنه من الـ general population،
+
+277
+00:27:13,690 --> 00:27:21,090
+احتمالية إنه يكون الأليل هو المصاب، واحد على ميتين،
+
+278
+00:27:21,090 --> 00:27:26,870
+فاحنا بالنسبة
+
+279
+00:27:26,870 --> 00:27:34,310
+للقصة هذه، والسلافة بهذه الطريقة، ماشي، بتقول الـ
+
+280
+00:27:34,310 --> 00:27:39,290
+general population، إنه يطلع carrier، ونعطينا الأليل
+
+281
+00:27:39,290 --> 00:27:44,370
+المصاب، 1 في الميتين، والمرأة هذه أنا متأكد إنها
+
+282
+00:27:44,370 --> 00:27:50,270
+carrier، فاحتمالية أن تعطينا الـ affected allele هو
+
+283
+00:27:50,270 --> 00:27:57,330
+نصف، فنصف × 1 على 200، بيطلع 1 على 400، فإجابتي راح تكون
+
+284
+00:27:57,330 --> 00:28:03,610
+1 على 400، لما تشوفوا الإجابة، اكتبوا 1 على 400،
+
+285
+00:28:03,610 --> 00:28:05,550
+ماشي؟
+
+286
+00:28:08,700 --> 00:28:14,040
+إن شاء الله واضحة، كريم
+
+287
+00:28:14,040 --> 00:28:19,340
+يبدو أنه واضح السؤال، فيه نقطة أنت بدك تسأل عنها
+
+288
+00:28:19,340 --> 00:28:25,300
+في المعادلة نفسها؟
+
+289
+00:28:25,300 --> 00:28:31,590
+لأ لأ، تمام، أنا بس حاطط السؤال، السؤال واضح، السؤال
+
+290
+00:28:31,590 --> 00:28:36,270
+يعني إحنا دائمًا نتذكر، يعني أنا بعتبر هدول الـ
+
+291
+00:28:36,270 --> 00:28:40,490
+«ثلاث معادلات» اللي ناتج عن «هاردي وينبرج»
+
+292
+00:28:40,490 --> 00:28:45,730
+Analysis، لازم لوحدك تحفظهم، وإذا بدي إجيك بدك تدور
+
+293
+00:28:45,730 --> 00:28:50,130
+عليهم، زي ما سوينه هنا، لما يجيني يعطيني
+
+294
+00:28:50,130 --> 00:28:59,270
+الـ prevalence، أو مدى انتشار المرض، اللي هو الـ Q
+
+295
+00:28:59,270 --> 00:29:05,460
+تربيع، الـ frequency of the disease individual
+
+296
+00:29:05,460 --> 00:29:10,400
+نسبتهم high لـ Q تربيع، إذاً الـ frequency تبعت
+
+297
+00:29:10,400 --> 00:29:16,640
+الأليل،  أعطاني نسبة، احتمالية إنه يكون
+
+298
+00:29:16,640 --> 00:29:21,180
+الواحد carrier لهذا الـ rare disease، هنا واحد على
+
+299
+00:29:21,180 --> 00:29:29,090
+ميتين، والأم في الحالة هذه أنا متأكد نصف، لأنها عندها
+
+300
+00:29:29,090 --> 00:29:35,710
+هي لازم تكون carrier، فالحالة الأولى هيك، نصيب إنه
+
+301
+00:29:35,710 --> 00:29:39,970
+من الميتين، الـ individual اللي أخذت منه الـ spare
+
+302
+00:29:39,970 --> 00:29:44,950
+كان كمان carrier، يعني هاي لو كانت، يعني زي ما نقول
+
+303
+00:29:44,950 --> 00:29:50,430
+اتجوزته، فإسا عندها خيار ثاني، بدأت تغير، وجابت إنسان
+
+304
+00:29:50,430 --> 00:29:57,940
+ثاني، يظل في قضية الاحتمالات، إنه إذا صار إشي أول مرة
+
+305
+00:29:57,940 --> 00:30:02,800
+مش بالضرورة إنه يصير المرة الثانية، كل حمل إشي
+
+306
+00:30:02,800 --> 00:30:08,520
+منفصل، والنسب بتظلها ثابتة، دا نفس الأبوين، يعني فهنا
+
+307
+00:30:08,520 --> 00:30:14,760
+واحد ثاني، برضه واحد على ميتين، فهي الاحتمالية نصف،
+
+308
+00:30:14,760 --> 00:30:20,020
+فبتصير واحد على أربعمية، فهيك بتمشي الأمور، ماشي؟ في
+
+309
+00:30:20,020 --> 00:30:20,840
+أسئلة أخرى؟
+
+310
+00:30:27,340 --> 00:30:33,120
+إذا حد بالـ chat عنده استفسار على سؤال آخر، نشوف
+
+311
+00:30:33,120 --> 00:30:36,280
+الـ chat، آه
+
+312
+00:30:41,500 --> 00:30:45,760
+دكتور، إذا الأسئلة اللي أنت حكيت إنه فيها الـ Stop
+
+313
+00:30:45,760 --> 00:30:54,220
+Codons، اللي هي UAA والـ UAG، هذه اللي ما .. يعني
+
+314
+00:30:54,220 --> 00:30:58,240
+ما ركزت أنت عليها في الأشياء؟ لأ، أنا .. أنا الفكرة
+
+315
+00:30:58,240 --> 00:31:02,000
+يعني إذا قريت السؤال، اللي جاوب هاديش الأسئلة على
+
+316
+00:31:02,000 --> 00:31:07,900
+هذه النقطة، يعني هي الـ trick اللي فيها إنك أنت
+
+317
+00:31:07,900 --> 00:31:14,560
+تنتبه، إذا الـ Codon لـ Amino Acid في النص، في نص
+
+318
+00:31:14,560 --> 00:31:21,360
+البروتين، اتحول لـ Stop Codon، شو رح يصير؟ عملية
+
+319
+00:31:21,360 --> 00:31:26,140
+بناء البروتين رح تتوقف، فراح يبقى لك البروتين
+
+320
+00:31:26,140 --> 00:31:30,460
+الناتج، هو بيقول لك البروتين الناتج قصير، البروتين
+
+321
+00:31:30,460 --> 00:31:37,380
+الناتج مش مظبوط، والسبب أن هاي اتغيرت لهاي، فاهم
+
+322
+00:31:37,380 --> 00:31:42,640
+عليك كيف؟ ففي الحالة هذه لما نشوف إنه كتاب لك، يعني
+
+323
+00:31:42,640 --> 00:31:48,880
+هظهرني هذا، السؤال الثاني أو الثالث، خلينا يعني
+
+324
+00:31:48,880 --> 00:31:56,900
+أشوف، يعني أنا استغربت، يعني هم الكتب بتتكلم على
+
+325
+00:31:56,900 --> 00:32:01,600
+أشياء مختلفة، يعني فيه مرات
+
+326
+00:32:04,070 --> 00:32:09,350
+يعني الـ Diseases، ولا كده، اللي بيشرحوا عنه، هي
+
+327
+00:32:09,350 --> 00:32:15,530
+بتعطيك فكرة، ولا هذه
+
+328
+00:32:15,530 --> 00:32:23,410
+بس لـ Gen دقيقة، خليني أطلّع السؤال، إيش اسمه؟ اللي
+
+329
+00:32:23,410 --> 00:32:28,370
+هو إنه عن الـ Alternative Splicing،
+
+330
+00:32:35,100 --> 00:32:41,880
+أنا هسا بدنا نروح ندور على السؤال، بس لما نكون أنه
+
+331
+00:32:41,880 --> 00:32:46,180
+يعني بهو بصفّ لك يعني الـ … الـ … الـ … الكويس في
+
+332
+00:32:46,180 --> 00:32:51,060
+الأسئلة هذول، صراحة،  كقالب الدراسة، أن نفسي أستمع
+
+333
+00:32:51,060 --> 00:32:56,360
+السؤال، هو هتطلق معلومات، يعني أنا هسا مثلًا شرحنا
+
+334
+00:32:56,360 --> 00:33:02,150
+موضوع الـ Hemophilia بشكل أكثر شوية، أنا مش قصدي هذا
+
+335
+00:33:02,150 --> 00:33:05,690
+أن نكون hematology lecture، يعني إحنا هذه المفروض
+
+336
+00:33:05,690 --> 00:33:08,670
+تاخدوها بالـ hematology، إحنا بدأنا نركز على الـ
+
+337
+00:33:08,670 --> 00:33:14,670
+genetics، فالـ genetics يعني simple، وهي هذه الـ
+
+338
+00:33:14,670 --> 00:33:21,490
+rules تبعتها، بحيث أنه لما نشوف الكلام اللي كاتبينه
+
+339
+00:33:21,490 --> 00:33:27,750
+بهذه الطريقة، شو اسمه؟ طيب
+
+340
+00:33:28,700 --> 00:33:38,680
+هذا أظن السؤال الثامن، ولا لأ؟ يعني
+
+341
+00:33:38,680 --> 00:33:43,200
+الأسئلة، أستمع الأسئلة صراحة دكتور أحمد، فيها
+
+342
+00:33:43,200 --> 00:33:49,660
+معلومات مفيدة، يعني أنت تخيلتها وكذا، بتلاقيك، و
+
+343
+00:33:49,660 --> 00:33:51,920
+بتستخدم، شو اسمه؟
+
+344
+00:33:56,640 --> 00:33:59,860
+المحققون يقومون بإزالة عيوب البشر ويقومون بإزالة
+
+345
+00:33:59,860 --> 00:34:01,120
+مصدر RNA مُحدث
+
+346
+00:34:01,120 --> 00:34:02,480
+
+347
+00:34:02,480 --> 00:34:03,120
+
+348
+00:34:03,120 --> 00:34:07,020
+
+349
+00:34:07,020 --> 00:34:07,160
+
+350
+00:34:07,160 --> 00:34:08,340
+
+351
+00:34:08,340 --> 00:34:23,020
+
+352
+00:34:23,020 --> 00:34:29,530
+بعد إدخال الـ Vector إلى مجموعات بكتيريا
+
+353
+00:34:29,530 --> 00:34:34,130
+المناسبة، تنتقل البكتيريا الهياركولترية إلى مجموعة
+
+354
+00:34:34,130 --> 00:34:39,470
+بيو-رياكترية، لإنشاء كميات كبيرة من البروتين اللي
+
+355
+00:34:39,470 --> 00:34:43,390
+تحتوي على المنطقة التي تتعامل مع مجموعة DNA محددة،
+
+356
+00:34:43,390 --> 00:34:48,070
+هذا البروتين هو أكثر شيوعًا مُستخدمًا لأي نوع من
+
+357
+00:34:48,070 --> 00:34:50,110
+الهرمونات التالية،
+
+358
+00:34:55,350 --> 00:35:03,230
+البروجسترون؟ والله ما أفهم هذا، يعني العيب
+
+359
+00:35:03,230 --> 00:35:10,630
+في السؤال هذا، بالنقطة الأولى، أنه
+
+360
+00:35:10,630 --> 00:35:16,830
+إذا ما عندك معلومات ثانية، الكلام اللي حاطه بيخربطك،
+
+361
+00:35:16,830 --> 00:35:22,880
+ومش مفيد كثير كثير، بالنسبة لبعض الأحيان، يعني هذه
+
+362
+00:35:22,880 --> 00:35:30,260
+تحتاج إلى معلومة تكون عارفها، الآن بسأل، بسأل مثل
+
+363
+00:35:30,260 --> 00:35:37,520
+كريم، أو اللي بدك، يعني الإنسولين اللي نستخدمه، شو
+
+364
+00:35:37,520 --> 00:35:42,060
+هو؟ من وين بتجيبه؟ شايف الإنسولين، الإبرة اللي
+
+365
+00:35:42,060 --> 00:35:45,880
+بنعطي المرضى السكري؟ سواء type 1 أو type 2،
+
+366
+00:35:45,880 --> 00:35:49,260
+بنعطيهم إنسولين، من وين بنجيبه؟
+
+367
+00:35:56,590 --> 00:36:02,290
+أي طالب بيحب يشارك؟
+
+368
+00:36:02,290 --> 00:36:09,690
+نعم، أهلاً
+
+369
+00:36:09,690 --> 00:36:14,210
+وسهلاً، الله يرضى عليك يا كريم، أنت أو أي طالب ثاني،
+
+370
+00:36:14,210 --> 00:36:19,550
+الإنسولين اللي بنستخدمه في علاج الآن مرضى السكري،
+
+371
+00:36:19,550 --> 00:36:23,930
+بنقول عنه human insulin، من وين بنجيبه؟
+
+372
+00:36:27,400 --> 00:36:33,840
+يُصنع في المختبرات، آه، كيف؟
+
+373
+00:36:33,840 --> 00:36:37,480
+أعتقد أول ما استُخلص، استُخلص من الخنزير، وبعدين
+
+374
+00:36:37,480 --> 00:36:43,180
+صاروا ياخدوا الجينات من الإنسان، وصاروا يصنعون البروتينات
+
+375
+00:36:43,180 --> 00:36:48,860
+في المختبر، صحيح، لأ، مش بالمختبر، مختبر، يعني هيك
+
+376
+00:36:48,860 --> 00:36:52,240
+فالنسبة
+
+377
+00:36:52,240 --> 00:36:53,420
+لهذا الموضوع
+
+378
+00:36:56,560 --> 00:37:04,260
+بالنسبة للـ «إنسولين»
+
+379
+00:37:04,260 --> 00:37:10,660
+زمان، أول شيء كانوا يعزلوا الهرمون، اللي هو البروتين،
+
+380
+00:37:10,660 --> 00:37:18,640
+يعزلوا من البقر ومن البقرة، فيقدروا يفلترُوا
+
+381
+00:37:18,640 --> 00:37:22,640
+دمها، ويعزلوا شوية البروتين اللي هو الـ «إنسولين»
+
+382
+00:37:22,640 --> 00:37:28,270
+تبع البقر، وبعدين يحقنه الإنسان فيه، فهيك يعني أصلاً
+
+383
+00:37:28,270 --> 00:37:35,610
+هذا البروتين مش متطابق كتير مع المُستقبل للإنسولين
+
+384
+00:37:35,610 --> 00:37:41,150
+اللي عند الإنسان، ففيه مشكلة، زائد أنه يعني تركيبته
+
+385
+00:37:41,150 --> 00:37:45,970
+شوية مختلفة عن الإنسولين البشري، وبالتالي فيه مشكلة،
+
+386
+00:37:45,970 --> 00:37:50,650
+فبالتالي ما كانش نافع كتير، بس المرضى كانوا يموتوا
+
+387
+00:37:50,650 --> 00:37:56,520
+ومضطرين نعطيهم إياه، تمام؟ فهسا لما تقول أنت يا كريم
+
+388
+00:37:56,520 --> 00:38:02,480
+كيف صنعوه في المختبر، الـ stem، السؤال بيشرح كيف
+
+389
+00:38:02,480 --> 00:38:07,360
+صنعوه أصلاً
+
+390
+00:38:07,360 --> 00:38:13,080
+لما أنت أنت بتكون مهتم بهذا الشيء، هدفك أول شيء
+
+391
+00:38:13,080 --> 00:38:19,460
+تعزل الـ gene تبعه، ماشي؟ بدك تعزل الـ DNA اللي
+
+392
+00:38:19,460 --> 00:38:26,330
+بيحتوي على الـ Insulin تبعه، الـ … الـ … الشيء اللي أنت بدك
+
+393
+00:38:26,330 --> 00:38:32,170
+إياه، فيه مشكلة، بالنسبة لمن يقول أنا بدي آخذ الـ
+
+394
+00:38:32,170 --> 00:38:36,790
+«جين» أو الـ «DNA» مباشرة من الإنسان، لأنه فيه شيء
+
+395
+00:38:36,790 --> 00:38:40,470
+اسمه «Intron وإكسون»، يعني لما تأخذ أنت الـ «DNA»
+
+396
+00:38:40,470 --> 00:38:46,470
+كله، ما بتقدر تأخذ، يعني القطعة اللي لازم بس، هي اللي
+
+397
+00:38:46,470 --> 00:38:49,950
+تصيرها ال
+
+445
+00:43:06,800 --> 00:43:10,780
+receptor اللي لهم على سطح الخلية للـ lipid hormone
+
+446
+00:43:11,270 --> 00:43:15,990
+اللي هم الـ Steroids، فيه Glucocorticoids،
+
+447
+00:43:15,990 --> 00:43:19,530
+Mineralocorticoids، Sex Hormones، الأشياء اللي زي
+
+448
+00:43:19,530 --> 00:43:24,590
+هيك، الـ Receptor تبعهم Intracytoplasmic، فهنا يعني
+
+449
+00:43:24,590 --> 00:43:28,690
+أنا أظن السؤال، الـ trick اللي فيه أن هدولة كلهم
+
+450
+00:43:28,690 --> 00:43:32,810
+بالأخير بروتينات، الـ glucagon و الإنسولين
+
+451
+00:43:32,810 --> 00:43:38,170
+و الإنسولين و البروتيرويد و البروجستيرون و الوحيد الـ
+
+452
+00:43:38,170 --> 00:43:42,130
+intraceptive،  أنا ما فاهم أنا يعني أكيد
+
+453
+00:43:42,130 --> 00:43:50,060
+جابتهم صحيحة، ما شاء الله، هنا بقول لك DNA-binding proteins
+
+454
+00:43:50,060 --> 00:43:53,880
+include transcription factors، Steroids receptors
+
+455
+00:43:53,880 --> 00:43:56,820
+and thyroid hormone receptors, fat-soluble
+
+456
+00:43:56,820 --> 00:44:00,360
+receptors, vitamin D، DNA transcription or
+
+457
+00:44:00,360 --> 00:44:10,960
+replication proteins، ماشي، سؤال صعب و يعني بتكلم
+
+458
+00:44:10,960 --> 00:44:14,340
+عن مواضيع عميقة كتير و يعني
+
+459
+00:44:15,680 --> 00:44:20,920
+بدو الواحد على الأقل، يعني أنا لو طلعت على السؤال
+
+460
+00:44:20,920 --> 00:44:25,540
+ما كنت راح عارف أجاوبه، كنت راح أقول يمكن الـ high
+
+461
+00:44:25,540 --> 00:44:30,520
+البروجستيرون على أساس هو من نوعية مختلفة، يعني استغربت
+
+462
+00:44:30,520 --> 00:44:34,440
+السؤال، واضح فيه أشياء كتير، وبعدين بيجي بالأخير
+
+463
+00:44:34,440 --> 00:44:38,720
+يقول لك أن هذا receptor لهرمون، أنو هرمون هذا والله
+
+464
+00:44:38,720 --> 00:44:40,860
+ما بعرفها، ما كنت عارفها من قبل
+
+465
+00:44:45,120 --> 00:44:54,080
+في سؤال من دكتورة نادية في السؤال السابق اللي كان
+
+466
+00:44:54,080 --> 00:44:59,840
+فيه عن الـ Weinberg equation، يقول الدكتور المفترض
+
+467
+00:44:59,840 --> 00:45:05,260
+إحتمالية أنه يكون حامل للمرض هي 2Q و مش Q، وإحتمال
+
+468
+00:45:05,260 --> 00:45:10,510
+أنه ينقل الأليل المصاب في حالة لو كان حامل هي نصف، مش
+
+469
+00:45:10,510 --> 00:45:17,210
+عارف هي بتسأل ولا بتعلق؟ مش موجودة اللي بدونها
+
+470
+00:45:17,210 --> 00:45:23,410
+طلعت أو شيء زي هيك، ناشي دكتور أحمد بدي أبلغك التالي
+
+471
+00:45:23,410 --> 00:45:30,490
+في فرق بين نظري ناشي و بين إنسان، أنا عندي معلومة
+
+472
+00:45:30,490 --> 00:45:42,890
+عنه، أساساً أنا عندي شخصين حاملين carrier، ماشي يعني الـ
+
+473
+00:45:42,890 --> 00:45:47,830
+… لما الـ … السؤال اللي بتحكي عنه عن المعادلة
+
+474
+00:45:47,830 --> 00:45:52,170
+دكتور أحمد معي، الله يطعمه صحيح يا دكتور
+
+475
+00:45:52,170 --> 00:45:59,450
+إثنين عندهم طفل مصاب، إذن الأب و الأم حاملين لـ X
+
+476
+00:45:59,450 --> 00:46:02,350
+-linked recessive أو Autosomal recessive، خليني أقول
+
+477
+00:46:02,350 --> 00:46:04,110
+Autosomal recessive، ماشي
+
+478
+00:46:08,330 --> 00:46:16,830
+لما نكون على حسب المعادلة إثنين عندهم carrier، صح؟
+
+479
+00:46:16,830 --> 00:46:20,650
+تمام؟
+
+480
+00:46:20,650 --> 00:46:26,090
+تمام إن شاء الله، إذا في طفل مصاب معناته أكيد الأب
+
+481
+00:46:26,090 --> 00:46:34,310
+و الأم carrier، صح؟ صحيح، أفرض جاوبوا بدهم يجيبوا بدهم
+
+482
+00:46:34,310 --> 00:46:43,110
+يخلفوا، عندهم طفل شو اسمه؟ عندهم طفل يعني حامل
+
+483
+00:46:43,110 --> 00:46:50,370
+مُرافقه و بدنا نسأل شو نسبة إنه يطلع carrier، إنه يطلع
+
+484
+00:46:50,370 --> 00:46:57,870
+carrier، ماشي، نصف إنه يطلع إنسان مصاب، ربع إنه يطلع
+
+485
+00:46:57,870 --> 00:47:03,070
+completely healthy، ربع، هدول النسب لشخص، أنا ما بعرف
+
+486
+00:47:03,070 --> 00:47:08,490
+هو راح يطلع مصاب ولا مش مصاب، فاهم عليّ أيه؟ بس زي
+
+487
+00:47:08,490 --> 00:47:13,510
+النسب اللي أخذناها البنت
+
+488
+00:47:13,510 --> 00:47:22,630
+هذه، ماشي، اللي كانت تسأل لأنه هي حامل و أخوها مصاب
+
+489
+00:47:22,630 --> 00:47:31,890
+ماشي، هي في احتمال أنها تكون مصابة؟ شو رأيك؟ إذا كان
+
+490
+00:47:31,890 --> 00:47:35,450
+الوالد و الوالدة، واحد منهم هو اللي بيحمل
+
+491
+00:47:35,450 --> 00:47:59,090
+ال………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………
+
+492
+00:48:00,500 --> 00:48:07,100
+البنت لمّا أنقجت و عمرها مثلًا عشرين سنة و صارت حامل
+
+493
+00:48:08,090 --> 00:48:16,010
+ما هي إحتمالية أنها تكون ربع، بربع، بنص، ربع
+
+494
+00:48:16,010 --> 00:48:24,470
+إنها مصابة، ربع إنها مصابة،
+
+495
+00:48:24,470 --> 00:48:27,850
+ربع إنها مصابة، ربع إنها مصابة، ربع إنها
+
+496
+00:48:27,850 --> 00:48:37,830
+مصابة، ربع إنها مصابة،
+
+497
+00:48:39,660 --> 00:48:46,440
+قلنا نصف؟ لأ، سلسان بيصير هيك؟ بيصير سلسان صحيح،
+
+498
+00:48:46,440 --> 00:48:49,640
+لأن أنت تلغي إحتمال من الـ "حامل" لغاية الربع إنه
+
+499
+00:48:49,640 --> 00:48:53,980
+حامل اللي هو المصاب، هي أكيد مش مصابة، بس شو
+
+500
+00:48:53,980 --> 00:49:00,380
+إحتمالية إنها حامل، بتكون يا إما سلسة، الثلاثة
+
+501
+00:49:00,380 --> 00:49:06,160
+أرباع اللي ضايلات، بخليهم واحد، سلسة بتكون إنها
+
+502
+00:49:06,160 --> 00:49:10,580
+completely normal، و ثلثين إحتمالية إنها تكون
+
+503
+00:49:10,580 --> 00:49:16,140
+"Carrier"، "Carrier"، مظبوط، و هي أنا غيرت النسب لأنه
+
+504
+00:49:16,140 --> 00:49:20,460
+أنا عرفت إنها مش مصابة، هو في سؤال مشابه للفكرة هذه
+
+505
+00:49:20,460 --> 00:49:22,780
+برضه موجود في التقرير اللي فات، ما إحنا اتناقشنا
+
+506
+00:49:22,780 --> 00:49:29,300
+على شيء زي هيك، المحاضرة اللي فاتت، في سؤال نفس
+
+507
+00:49:29,300 --> 00:49:33,900
+الفكرة أو نفس المنطق، موجود في الكتاب نفسه، كتاب
+
+508
+00:49:33,900 --> 00:49:40,290
+Kaplan، آه آه آه، النسبة كانت الجواب ثلثين صحيح لأنه
+
+509
+00:49:40,290 --> 00:49:43,630
+في سؤال اللي كانت الثلث، أجاني واحد سألني ليش أجت
+
+510
+00:49:43,630 --> 00:49:50,510
+الثلث، الثلث لأنه أنا تأكدت إنه هي هي مش مصابة
+
+511
+00:49:50,510 --> 00:49:55,090
+مظهرياً، بما أنه مش مصابة، إحتمالية الجزء اللي فيه
+
+512
+00:49:55,090 --> 00:50:00,680
+بتمثل إنها مصابة، لو كان لسه الأم حامل، ماشي، و
+
+513
+00:50:00,680 --> 00:50:07,580
+بتسألني أنت شو إحتمالية أنه البنت أو اللي راح يولد
+
+514
+00:50:07,580 --> 00:50:13,780
+ولد ولا بنت يطلع مثلًا carrier، بقول لك نصف، مصاب ربع،
+
+515
+00:50:13,780 --> 00:50:18,500
+أنه يكون طبيعي completely normal ربع، ماشي، إذا
+
+516
+00:50:18,500 --> 00:50:22,940
+سألني شو إحتمالية مظهرياً يكون طبيعي، بقول لك ثلاثة
+
+517
+00:50:22,940 --> 00:50:30,590
+أرباع، carrier و normal، إذا طلعت هي Normal-looking،
+
+518
+00:50:30,590 --> 00:50:33,550
+Phenotypical، هي شو إحتمالية إنها تكون carrier
+
+519
+00:50:33,550 --> 00:50:39,790
+الثلثين، هيك راح تكون، فهي النقطة إنه يعني الواحد
+
+520
+00:50:39,790 --> 00:50:50,770
+يرسم الجدول و معين يعرف هل أنا بحكي، يعني لما أنصح
+
+521
+00:50:50,770 --> 00:50:56,050
+أو أجاوب السؤال عن شيء أنا متأكد منه، يعني اللي هي
+
+522
+00:50:56,050 --> 00:51:01,690
+إنه، يعني بالذات الآباء و الأمهات اللي راح يعطوا
+
+523
+00:51:01,690 --> 00:51:07,770
+مثلًا، مثلًا بقول لك الطفل
+
+524
+00:51:07,770 --> 00:51:12,250
+اللي هو هذا طلع عنده إصابة، شو الحمل اللي بعده
+
+525
+00:51:12,250 --> 00:51:16,090
+إحتمالية إنه يطلع عنده إصابة؟ الـ Autism-recessive
+
+526
+00:51:16,090 --> 00:51:20,770
+بتكون ربع، لأن أنا متأكد الأباء الإثنين carriers
+
+527
+00:51:20,770 --> 00:51:27,200
+لأنه طلع ولد مصاب من قبل، إذا من قبل أنا متأكد
+
+528
+00:51:27,200 --> 00:51:31,080
+الإثنين carrier، يعني زي مثل الـ Bomb Disease هذا
+
+529
+00:51:31,080 --> 00:51:37,680
+الحالة، الطفل الأولاني اللي جابته المرأة هذه، الأبو
+
+530
+00:51:37,680 --> 00:51:42,320
+أكيد carrier، فهو واحد من الإثنين اللي عندهم
+
+531
+00:51:42,320 --> 00:51:48,920
+الـ Gene هذا طلع بالصدفة، بالحظ السيء إنه كمان هو
+
+532
+00:51:48,920 --> 00:51:53,970
+حامل، شايف عليّ؟ واحد من الإثنين، يعني إحتمالية
+
+533
+00:51:53,970 --> 00:52:00,930
+قليلة، بس هذا نصيبهم، ماشي، فالآن اللي لما يقول لك
+
+534
+00:52:00,930 --> 00:52:05,130
+"طب شو إحتمالية أن الطفل اللي بعده يكون نفس
+
+535
+00:52:05,130 --> 00:52:11,030
+الشيء؟" بتقول "لأن الأم بدل ما هي النسبة واحد في
+
+536
+00:52:11,030 --> 00:52:14,970
+كل أربعين ألف في الشكل الطبيعي، بما أن أنا عرفت أن
+
+537
+00:52:14,970 --> 00:52:18,790
+الأم هي الـ Carrier و كانت هي اللي حاملة الـ Gene،
+
+538
+00:52:18,790 --> 00:52:23,750
+فإذا إحتمالية أن هي تنقل نصف، من هناك 1 على 200 بتصير
+
+539
+00:52:23,750 --> 00:52:30,330
+1 على 400، هيك بدأ أفكر، نعم كريم، كان عندك تعليق
+
+540
+00:52:30,330 --> 00:52:34,870
+حابب تحكي كنت؟
+
+541
+00:52:34,870 --> 00:52:39,450
+لقيت بخصوص سؤال 20 اللي بيحكي عن دكتورة قبل شوية،
+
+542
+00:52:39,450 --> 00:52:43,810
+هو قرأت أنا تفسير السؤال منذ فترة، فالجواب الصح هو
+
+543
+00:52:43,810 --> 00:52:48,630
+بيطلع 1/400، ولكن الرقم 1 على 200 هذا ما بيجي
+
+544
+00:52:48,630 --> 00:52:54,590
+مباشر، الـ  بنفرض أن
+
+545
+00:52:54,590 --> 00:53:00,430
+الـ "سبرم دونار" الثاني يكون "كارير"، وبعد هيك بنفرض
+
+546
+00:53:00,430 --> 00:53:05,270
+أن إحتمال توريث الأليل المصاب للإبن هو نصف، فلذلك
+
+547
+00:53:05,270 --> 00:53:09,570
+بنقول، بنفرض إنه carrier، فبتخدم قانون إثنين و بيه،
+
+548
+00:53:09,570 --> 00:53:15,870
+يعني بنقول إثنين × واحد على 200 × 109 
+
+549
+00:53:15,870 --> 00:53:22,500
+كريم كريم، سؤالك بالشكل هذا بخطر على بالي أو كنت
+
+550
+00:53:22,500 --> 00:53:31,300
+فاكر فيه، بس خلّي الأمور سهلة، ماشي، الـ wording لما
+
+551
+00:53:31,300 --> 00:53:39,920
+نحكي على النسب، ماشي، الواحد على الميتين من النسخة
+
+552
+00:53:39,920 --> 00:53:45,060
+كام يعني بدك تاخدها بهذا الشكل، يعني صح، يعني لأ،
+
+553
+00:53:45,060 --> 00:53:49,020
+لا، لا تدخل الموضوعين شوية تربطهم، اتبعاد، تتفكر
+
+554
+00:53:49,020 --> 00:53:58,600
+كتير، ماشي؟ الـ … الـ … لما نقول يعني هي طريقة
+
+555
+00:53:58,600 --> 00:54:04,620
+حسبتها و طريقة التعامل معاها، ماشي؟ الـ … يعني إذا
+
+556
+00:54:04,620 --> 00:54:09,060
+حطوا واحد على 800، بدو الواحد هيك يكون متفكر كتير،
+
+557
+00:54:09,060 --> 00:54:15,200
+كتير كتير و يخربط حاله، ماشي؟ لما إحنا نحكي الآن على
+
+558
+00:54:15,200 --> 00:54:23,060
+الـ … لما مثلًا تقول الـ …
+
+559
+00:54:23,060 --> 00:54:32,160
+مثلًا تقول، مثلًا اللي عندهم O blood group، نقول تسعة
+
+560
+00:54:32,160 --> 00:54:39,700
+بالألف، بالنسبة له؟ ماشي؟ ماشي الحال يا كريم؟ آه دكتور
+
+561
+00:54:39,700 --> 00:54:47,340
+صحيح، هاي الـ Q تربيع، صح؟ لأن هذا recessive صحيح،
+
+562
+00:54:47,340 --> 00:54:58,240
+إذا شو إحتمالية إنه الـ Gene يكون موجود؟ شو الـ Q؟
+
+563
+00:54:58,240 --> 00:55:03,260
+الـ 900، نعم،
+
+564
+00:55:03,260 --> 00:55:08,860
+فهيكون الـ Gene 39%، رح يكون ثلاثة من عشرة، يعني رح
+
+565
+00:55:08,860 --> 00:55:14,780
+يكون 0.3، صح؟ صحيح، هاي الـ 0.3
+
+566
+00:55:14,780 --> 00:55:21,320
+على نسخة هون أو نسخة هناك أو النسختين مع بعض، فاهم
+
+567
+00:55:21,320 --> 00:55:27,320
+عليك كيف؟ يعني ثلاثين بالمئة من الإجمالي الـ two
+
+568
+00:55:27,320 --> 00:55:32,780
+copies الممكنات في كل واحد، هي نسبتها واحد على
+
+569
+00:55:32,780 --> 00:55:38,860
+ثلاثة، هيك بدك توقفها، ما بأخد إنه هذه نسبة لـ copy
+
+570
+00:55:38,860 --> 00:55:43,900
+واحدة ولا two copies ولا كده، هو هنا بيقول لك أن الـ
+
+571
+00:55:43,900 --> 00:55:49,400
+Q هي نسبة أنك أنت بتيجي بتاخد الجينات تبعت هذا
+
+572
+00:55:49,400 --> 00:55:56,360
+المكان لكل الـ "population" و بتشوف قداش نسبة هذا
+
+573
+00:55:56,360 --> 00:56:00,060
+الـ "gene"، طبعًا على الـ "two copies"، بدي تكون
+
+574
+00:56:00,060 --> 00:56:05,800
+و إنت ما فرقت إنه one copy هاي ولا هاي ولا إثنتين
+
+575
+00:56:05,800 --> 00:56:09,940
+مع بعض، فاهم عليك أيه؟ إنه إذا إنت مثلًا عندك هنا
+
+576
+00:56:09,940 --> 00:56:13,160
+two copies، ممكن تقول هاي الـ copy الأولى و هاي الـ
+
+577
+00:56:13,160 --> 00:56:18,950
+copy الثانية للـ "gene" الموقع هذا، أنا هنا ما بشتغل
+
+578
+00:56:18,950 --> 00:56:23,230
+على ذاك المبدأ، يعني فأنت خدها ببساطة إنه لما
+
+579
+00:56:23,230 --> 00:56:28,170
+نحط لك السؤال هيك إنه أنا ما بعرف هي الـ copy
+
+580
+00:56:28,170 --> 00:56:31,670
+الأولى ولا الثانية ولا الـ homozygous إنه الإثنين
+
+581
+00:56:31,670 --> 00:56:36,250
+هيك، بس نسبة الـ Gene هذا هيك ببساطة في الـ
+
+582
+00:56:36,250 --> 00:56:41,430
+population، واحد في الألف، و هذه المرة يعني للأبو
+
+583
+00:56:41,900 --> 00:56:48,660
+للجهة هذه، نسبة توريث الأليل المصاب هو 1 على 200،
+
+584
+00:56:48,660 --> 00:56:55,300
+هيك القصة ماشي، و الأم carrier أكيد، فبالتالي، نسبة
+
+585
+00:56:55,300 --> 00:56:59,660
+إعطائها للـ chromosome للأليل هذا، 1 على 2، فبتطلع
+
+586
+00:56:59,660 --> 00:57:05,220
+النتيجة 1 على 400، ما أنا قلت إنه أنا بتكلم على
+
+587
+00:57:05,220 --> 00:57:10,040
+نموذج إنه واحد من الـ two copies هو الـ 1 على 200
+
+588
+00:57:10,740 --> 00:57:14,940
+لأ، ما حكيت هيك، حكيت كلها، فاهم عليك كيف؟ فهذه
+
+589
+00:57:14,940 --> 00:57:19,200
+الواحد ينتبه عليها، بتخربط شوية، آه، في أسئلة
+
+590
+00:57:19,200 --> 00:57:24,080
+أخرى؟ دكتور، أظن السؤال اللي بتدور عليه هو السؤال
+
+591
+00:57:24,080 --> 00:57:30,020
+11، آه، شو السؤال 11؟ هو الإجابة الأول ولا الثاني؟
+
+592
+00:57:30,020 --> 00:57:33,960
+الأول، الأول، طيب،
+
+593
+00:57:33,960 --> 00:57:41,310
+طيب، أيوة، هذا هو، ماشي؟ إذا حاولنا نقرأ الـ stem،
+
+594
+00:57:41,310 --> 00:57:44,930
+خليني نرجع للقبل كـ Pharmaceutical researcher
+
+595
+00:57:44,930 --> 00:57:49,330
+develops a new drug that affects bacterial protein
+
+596
+00:57:49,330 --> 00:57:55,350
+synthesis in an experiment، الـ E. coli was exposed
+
+597
+00:57:55,350 --> 00:57:59,330
+to that drug and serially cultured in media tagged
+
+598
+00:57:59,330 --> 00:58:03,840
+nucleotides and amino acids، يعني كل هذا الكلام يعني
+
+599
+00:58:03,840 --> 00:58:08,000
+بيشرح لك الـ … شو اسمه؟ الـ … الـ شيء الـ … الـ …
+
+600
+00:58:08,000 --> 00:58:12,120
+يعني السيناريو زي اللي اتكلمنا قبل شوية عن الـ
+
+601
+00:58:12,120 --> 00:58:15,000
+Recombinant DNA Technology، بيشرح لك كيف أنهم
+
+602
+00:58:15,000 --> 00:58:18,340
+بيعملوها، للأيام هذه، It is found that the drug
+
+603
+00:58:18,340 --> 00:58:22,920
+inhibits molecules that recognize the heightened
+
+604
+00:58:22,920 --> 00:58:27,220
+codon in the bacterial messenger RNA fragment
+
+605
+00:58:27,220 --> 00:58:30,700
+shown in the image below، ماشي، which of the
+
+606
+00:58:30,700 --> 00:58:39,770
+following molecules is، بالتأكيد، الهدف هو الـ
+
+607
+00:58:39,770 --> 00:59:00,650
+UUA، اللي هو جسمهم، أنا آسف، طلع السؤال، ماشي،
+
+608
+00:59:00,650 --> 00:59:02,150
+الـ
+
+609
+00:59:07,510 --> 00:59:14,410
+بالنسبة لـ Heightened Codon in the bacterial RNA
+
+610
+00:59:14,410 --> 00:59:20,710
+fragment shown in the image below، فالشيء
+
+611
+00:59:20,710 --> 00:59:24,250
+اللي هو هنا بيحاول، إحنا عكس اللي حكيناه من قبل
+
+612
+00:59:24,250 --> 00:59:32,340
+قبل شوية، مثال إنه أنا عندي بروتين، أجى فيه الـ Stop
+
+613
+00:59:32,340 --> 00:59:39,680
+codon بشكل نتيجة الـ mutation، و بيطلع عندي البروتين
+
+614
+00:59:39,680 --> 00:59:47,520
+
+667
+01:05:04,000 --> 01:05:08,700
+«أرستوب كودونز» هؤلاء الذكرهم يعني إذا بدي إشي
+
+668
+01:05:08,700 --> 01:05:13,600
+عشان تعرف تجاوب أسئلة، وإذا في سؤال بالأخير جابلك
+
+669
+01:05:13,600 --> 01:05:19,160
+إنه هي أجاب واحد من هذول الثلاثة، أعرف إنه فيه
+
+670
+01:05:19,160 --> 01:05:24,760
+يعني توقُّف أو توقُّف يمكن يسبب مرض، إنه في نص إشي
+
+671
+01:05:24,760 --> 01:05:31,210
+مطلوب أو يسبب مرض، إنّه المفروض أن البروتين الطبيعي
+
+672
+01:05:31,210 --> 01:05:35,890
+يكون هالطول، وتكون الـ stop codon مش موجودة، فتطلع
+
+673
+01:05:35,890 --> 01:05:39,530
+البروتين أطول، مش هو اللي أنا بدي إياه، فبتطلع
+
+674
+01:05:39,530 --> 01:05:48,430
+هيك، ماشي؟ دكتور، شوف سؤال 14، برنامج؟ طيب، احكي،
+
+675
+01:05:48,430 --> 01:05:56,470
+اقرأ النقطة قبل ما أوصل له، طيب
+
+676
+01:06:00,210 --> 01:06:06,350
+«طفلة مولودة لامرأة عمرها 34 عامًا، لديها صورة
+
+677
+01:06:06,350 --> 01:06:10,870
+رسمية بطيئة» ما
+
+678
+01:06:10,870 --> 01:06:19,410
+هو اسمه؟ يعني أيش الحالة اللي بتتكلم عنها؟
+
+679
+01:06:23,480 --> 01:06:27,760
+«ترايزومي 21»، «ترايزومي 21»، صحيح، ماشي، فيه Flat
+
+680
+01:06:27,760 --> 01:06:31,860
+Facial Profile، Prominent Epicanthal Fold زي تبعات
+
+681
+01:06:31,860 --> 01:06:35,740
+العيون، بتخليهم زي الصينيين، A Holocystolic Murmur
+
+682
+01:06:35,740 --> 01:06:38,860
+Heard Loudest at the Left External Border، بيكون
+
+683
+01:06:38,860 --> 01:06:42,440
+Congenital Heart Disease، VSD، ولا كده، وهذا بتصير
+
+684
+01:06:42,440 --> 01:06:47,140
+الـ Karyotype Analysis is consistent with Trisomy
+
+685
+01:06:47,140 --> 01:06:47,660
+21
+
+686
+01:06:50,160 --> 01:06:54,960
+ماشي، Maternal and Paternal Karyotypes are normal
+
+687
+01:06:54,960 --> 01:06:59,620
+الـ Karyotype analysis consistent with the Trisomy
+
+688
+01:06:59,620 --> 01:07:05,780
+21، عند مين يا دكتور معتز؟ عند الأم؟ لأ
+
+689
+01:07:08,700 --> 01:07:15,680
+هو عند الطفل المصاب عنده
+
+690
+01:07:15,680 --> 01:07:21,280
+نفسه، هو إتلقينا الـ Trisomy 21، فحصنا أمه
+
+691
+01:07:21,280 --> 01:07:26,720
+وأبوه، طلعوا Normal، طلعوا Normal، ماشي، A restricted
+
+692
+01:07:26,720 --> 01:07:31,820
+fragment-length polymorphism analysis is conducted
+
+693
+01:07:31,820 --> 01:07:35,600
+to determine the parental origin of the extra
+
+694
+01:07:35,600 --> 01:07:41,610
+chromosome، يعني شو اللي عملوه هنا؟ هذه واحدة من الـ
+
+695
+01:07:41,610 --> 01:07:47,230
+Restriction Fragment Length Polymorphism، الـ
+
+696
+01:07:47,230 --> 01:07:54,250
+Restriction Enzyme هو إنزايم ماشي بيقطع الـ DNA في
+
+697
+01:07:54,250 --> 01:08:01,190
+أماكن محددة، يعني إله قطعة معينة إذا شافها، وقوم هيك
+
+698
+01:08:01,190 --> 01:08:07,550
+بنصها، بيقطع الـ DNA، فبينتج عن الموضوع هذا إنه كيف
+
+699
+01:08:07,550 --> 01:08:13,050
+يعني بنستفيد من هذه الخاصية، أنه أنا لما نقطع بهذا
+
+700
+01:08:13,050 --> 01:08:20,650
+المكان، راح ينتج عندي مجموعة قطع أطوالها مختلفة بين
+
+701
+01:08:20,650 --> 01:08:29,470
+الناس، فاهم علي كيف؟ فالآن يعني كيف أعرف إنه قطع
+
+702
+01:08:29,470 --> 01:08:37,070
+أطوالها مختلفة؟ إنه باجي بعمل Electrophoresis، ماشي،
+
+703
+01:08:37,070 --> 01:08:40,410
+فلما أسوي Electrophoresis، مين اللي بيظل عند
+
+704
+01:08:40,410 --> 01:08:46,470
+الـ Origin أو بطيء، بيكون الإثقال الكبار والصغار
+
+705
+01:08:46,470 --> 01:08:55,130
+الأخفاف بيطيروا لقدام كثير، واضح؟ تمام، فالآن اللي
+
+706
+01:08:55,130 --> 01:09:01,250
+عملوا هذه النوع من الدراسة، اللي هي Restriction,
+
+707
+01:09:01,370 --> 01:09:05,480
+Fragment, Length, Polymorphism، للتحقق في تحقيق الـ
+
+708
+01:09:05,480 --> 01:09:10,500
+Lithopoiebolism، كان يتم تحقيقه، للتحقق من أصل الأطفال
+
+709
+01:09:10,500 --> 01:09:15,440
+للـ Extra Chromosome، يعني أجوا وعملوا الدراسة هذه
+
+710
+01:09:15,440 --> 01:09:21,420
+للجنين المصاب، على الطفل المصاب، والأب والأم، عشان
+
+711
+01:09:21,420 --> 01:09:28,420
+يشوفوا من أين أخذ المرض هذا، تمام؟ ماشي الحال؟
+
+712
+01:09:28,420 --> 01:09:32,340
+أمامك، الله، الـ DNA samples from the child, mother
+
+713
+01:09:32,340 --> 01:09:36,460
+and father were obtained and the DNA is fragmented
+
+714
+01:09:36,460 --> 01:09:39,860
+with a restriction enzyme، the fragments are then
+
+715
+01:09:39,860 --> 01:09:44,500
+sorted، يعني عملنا Electrophoresis by size
+
+716
+01:09:44,500 --> 01:09:48,860
+using Southern blot technique، الـ Southern blot هذا
+
+717
+01:09:48,860 --> 01:09:52,280
+نوعية، بعد ما تعمل أنت Electrophoresis ما بتقدر
+
+718
+01:09:52,280 --> 01:09:57,120
+تشوفهم، فبتجيب، بعد ما تعمل الـ Electrophoresis، بتحط
+
+719
+01:09:57,120 --> 01:10:02,760
+عليها طبقة ثانية، وبتسمحله يصير Blocking، يعني طبق
+
+720
+01:10:02,760 --> 01:10:09,380
+وبتشوف أين أجي المكان تبعه، فـ Labeling is done
+
+721
+01:10:09,380 --> 01:10:12,700
+using a probe that binds to a specific DNA
+
+722
+01:10:12,700 --> 01:10:16,700
+sequence close to the centromere of chromosome 21
+
+723
+01:10:16,700 --> 01:10:23,190
+The Repelif Analysis of the child, mother is shown
+
+724
+01:10:23,190 --> 01:10:27,590
+below، فهيك شكله الأم، هيك الأب، هيك
+
+725
+01:10:27,590 --> 01:10:34,110
+والطفل، هيك، هذول يعني مكان وين الـ centromere
+
+726
+01:10:34,110 --> 01:10:41,030
+تبع chromosome 21 موجود في كل واحد منهم، ماشي، الأم
+
+727
+01:10:41,030 --> 01:10:45,930
+قانها هذول اثنتين، الأب قانها
+
+728
+01:10:45,930 --> 01:10:51,870
+بالاثنتين، هذول، الطفل عنده هذول الثلاثة، ماشي،
+
+729
+01:10:51,870 --> 01:10:55,730
+إذا شو اللي صار عند هذا الطفل؟ المشكلة عند أبوه
+
+730
+01:10:55,730 --> 01:11:02,850
+ولا أمه يا معتز؟ عنده Trisomy 21، يعني ما ياخد two
+
+731
+01:11:02,850 --> 01:11:07,770
+copies من واحد، وما ياخد copy واحد من شخص ثاني، من
+
+732
+01:11:07,770 --> 01:11:12,250
+من من، تتوقع من من المشكلة؟ من الأم أخد two copies
+
+733
+01:11:12,250 --> 01:11:16,750
+من الأم أخد اثنتين، تفهم علي؟ فهو من الأم ماخد اثنتين
+
+734
+01:11:16,750 --> 01:11:20,970
+ومن الأب ماخد واحدة، الأب هاي واحدة بس، فذول اثنتين
+
+735
+01:11:20,970 --> 01:11:27,790
+تبعات الأم، من بينات عنده، فهو هنا المشكلة في الأم
+
+736
+01:11:27,790 --> 01:11:35,410
+ماشي الحال، شو اسمه؟ سؤال، Which of the following
+
+737
+01:11:35,410 --> 01:11:42,390
+meiosis events did this non-disjunction most likely
+
+738
+01:11:42,390 --> 01:11:47,990
+occur؟ طبعًا الأم غلط، استبعدناهم، استبعدناهم
+
+739
+01:11:47,990 --> 01:11:53,190
+الـ maternal meiosis one or two، قدرت، حيرت فيها
+
+740
+01:11:53,190 --> 01:11:56,530
+عشانك أنا سألت السؤال، يعني ما احنا قلنا إنه ممكن
+
+741
+01:11:56,530 --> 01:12:02,370
+تصير في واحد أو في اثنين، لأ، الواحد شو المطلوب
+
+742
+01:12:02,370 --> 01:12:11,450
+يصير؟ الواحد، مش أنت، يعني أنت تفهم الـ step الأولى
+
+743
+01:12:11,450 --> 01:12:18,250
+بالـ meiosis، بكون عندي الـ «أنا بسوي بالأول S
+
+744
+01:12:18,250 --> 01:12:19,550
+-phase»، «أنا بسوي بالأول S-phase»، «أنا بسوي بالأول
+
+745
+01:12:19,550 --> 01:12:20,130
+S-phase»، «أنا بسوي بالأول S-phase»، «أنا بسوي
+
+746
+01:12:20,130 --> 01:12:22,550
+بالأول S-phase»، «أنا بسوي بالأول S-phase»، «أنا
+
+747
+01:12:22,550 --> 01:12:23,610
+بسوي بالأول S-phase»، «أنا بسوي بالأول S-phase»
+
+748
+01:12:23,610 --> 01:12:23,810
+«أنا بسوي بالأول S-phase»، «أنا بسوي بالأول S
+
+749
+01:12:23,810 --> 01:12:23,830
+-phase»، «أنا بسوي بالأول S-phase»، «أنا بسوي بالأول
+
+750
+01:12:23,830 --> 01:12:27,170
+بالأول S-phase»، «أنا بسوي بالأول S-phase»، «أنا
+
+751
+01:12:27,170 --> 01:12:37,870
+بسوي بالأول S-phase»، «أنا بسوي بالأول S-phase»، بتنصم
+
+752
+01:12:37,870 --> 01:12:41,070
+الأثنين إلى واحد وواحد إلى واحد وواحد، فوين راح
+
+753
+01:12:41,070 --> 01:12:45,430
+تكون المشكلة؟ أنا بظنّ بميوزس 2، شو كتبت
+
+754
+01:12:45,430 --> 01:12:50,230
+الإجابة؟ وكتبت واحد،
+
+755
+01:12:50,230 --> 01:12:58,050
+هاي، فلأ، هحطها زي ما هم حكوا، أنا مش يعني، شو
+
+756
+01:12:58,050 --> 01:13:01,810
+اسمه؟ أتبروها، ليش طب مش اثنين؟
+
+757
+01:13:09,600 --> 01:13:21,080
+أه، هنا الـ 2N، ماشي، الـ 2N اللي انفصلوا هم الـ
+
+758
+01:13:21,080 --> 01:13:26,500
+chromatids، يعني نصي الكروموزوم، بيصيروا انفصلوا،
+
+759
+01:13:26,500 --> 01:13:32,940
+ماشي؟ فزي ما هم حاطينه هنا، الأصل أنه الـ non
+
+760
+01:13:32,940 --> 01:13:38,130
+-disjunction in meiosis، في الـ meiosis I، الأصل الـ
+
+761
+01:13:38,130 --> 01:13:43,870
+Normal إن يكون ينقسموا هيك وهيك، ماشي، هذول الـ
+
+762
+01:13:43,870 --> 01:13:49,090
+two copies from the same chromosome، بنقسموا بحيث
+
+763
+01:13:49,090 --> 01:13:51,350
+يكون one chromosome هنا و one chromosome هنا
+
+764
+01:13:51,350 --> 01:13:56,560
+وبعدين بنفصل بهذا الشكل، إذا كان الـ Non-Disjunction
+
+765
+01:13:56,560 --> 01:13:59,960
+ممكن يكون في الـ Meiosis I، وممكن يكون في الـ
+
+766
+01:13:59,960 --> 01:14:05,560
+Meiosis II، وهنا صار Non-Disjunction، وهنا الـ Step
+
+767
+01:14:05,560 --> 01:14:07,060
+الأولى Non-Disjunction
+
+768
+01:14:10,560 --> 01:14:13,260
+الـ Non-disjunction هي خسارة كروموزوم، ممكن أن
+
+769
+01:14:13,260 --> 01:14:16,380
+تتفرق بشكل صحيح خلال تقسيم الخلية، هذا يمكن أن يكون
+
+770
+01:14:16,380 --> 01:14:20,720
+بسبب خسارة كروموزوم متماثل، لتفرق في ميوزس 1، أو
+
+771
+01:14:20,720 --> 01:14:27,580
+خسارة أختي كروماتيد، لتفرق في ميوزس 2 أو ميتوسس،
+
+772
+01:14:27,580 --> 01:14:31,460
+في الـ Monosomy، خسارة كروموزوم متماثل في
+
+773
+01:14:31,460 --> 01:14:34,520
+الـ Trisomy، خسارة كروموزوم متماثل في الـ Gain،
+
+774
+01:14:34,520 --> 01:14:37,020
+الـ Monosomy أو الـ Trisomy بإمكانها أن تنتج من
+
+775
+01:14:37,020 --> 01:14:44,310
+مجموعة واحدة أو اثنتين، طيب، وبعدين non-disjunction
+
+776
+01:14:44,310 --> 01:14:47,510
+is a failure of chromosome pairs to separate، this
+
+777
+01:14:47,510 --> 01:14:53,590
+could be a failure of، طب ما حكيناها، shows that both
+
+778
+01:14:53,590 --> 01:14:57,230
+parents demonstrate two bands each، parental band
+
+779
+01:14:57,230 --> 01:15:01,170
+represents a homologous chromosome 21، this child
+
+780
+01:15:01,170 --> 01:15:08,020
+has three bands، اللي فهمته يا دكتورة إنه في الـ
+
+781
+01:15:08,020 --> 01:15:12,340
+Meiosis 1 الكروموسومات بتنفصل عن بعض، أما في الـ
+
+782
+01:15:12,340 --> 01:15:16,560
+Meiosis 2 الكروماتيد هي اللي بتنفصل، صحيح، صحيح هو
+
+783
+01:15:16,560 --> 01:15:21,580
+بيقول لك الـ Trisomy 21 هو الكروموزوم ما انفصلش، عشان
+
+784
+01:15:21,580 --> 01:15:25,340
+هيك في Meiosis 1؟ therefore the problem occurred
+
+785
+01:15:25,340 --> 01:15:29,120
+in the mother during Meiosis 1 when homologous
+
+786
+01:15:29,120 --> 01:15:34,670
+chromosomes are separated، صحيح، تمام، ماشي واضحة
+
+787
+01:15:34,670 --> 01:15:41,490
+الآن يا معتز؟ تمام، سؤال 16 كمان عن الـ
+
+788
+01:15:41,490 --> 01:15:50,610
+Electrophoresis، بعد أن هم مجلوبين، طيب،
+
+789
+01:15:50,610 --> 01:15:54,310
+A 26-year-old woman comes to the office with her
+
+790
+01:15:54,310 --> 01:15:57,610
+husband for genetic counseling، she's pregnant with
+
+791
+01:15:57,610 --> 01:16:01,650
+their second child، whose gender is unknown، مثلًا،
+
+792
+01:16:01,650 --> 01:16:05,550
+كلا الطفلين مميزين بشكل كام، وكانوا أولاً يولدوا
+
+793
+01:16:05,550 --> 01:16:09,090
+أولاً ابنة عمرها ثلاث سنوات، وكان لديها حالات مستمرة
+
+794
+01:16:09,090 --> 01:16:14,310
+من الأنيميا، واليرقان، وشعور مؤلم في يديها ورجليها،
+
+795
+01:16:14,310 --> 01:16:16,250
+وكانت مجموعة دم الفتاة
+
+796
+01:16:16,250 --> 01:16:19,310
+والهيموغلوبين الكتروفوريسيس
+
+797
+01:16:19,310 --> 01:16:22,510
+تم تجربتها في مجال الـ Alkaline pH، وهي الميزات
+
+798
+01:16:22,510 --> 01:16:24,770
+المظهرة هنا
+
+799
+01:16:36,520 --> 01:16:42,120
+هه؟ الـ Hemoglobin S، يعني Sickle Cell Disease،
+
+800
+01:16:42,120 --> 01:16:49,040
+الأنيميا والـ Jaundice، ماشي، ما أعرفش ليش الـ
+
+801
+01:16:49,040 --> 01:16:55,420
+swellings of the hands and feet، السبب، فالـ بالنسبة
+
+802
+01:16:55,420 --> 01:17:00,000
+له في الحالة هذه بكون
+
+803
+01:17:00,000 --> 01:17:02,020
+شو اسمه؟
+
+804
+01:17:08,300 --> 01:17:12,880
+عملوا Hemoglobin Electrophoresis هنا، فالـ
+
+805
+01:17:12,880 --> 01:17:19,860
+Hemoglobin A مش موجود، هذا لمين؟ للطفل المصاب، صح؟
+
+806
+01:17:19,860 --> 01:17:24,080
+Blood sample is obtained from the boy and
+
+807
+01:17:24,080 --> 01:17:27,260
+Hemoglobin Electrophoresis is performed at
+
+808
+01:17:27,260 --> 01:17:33,800
+alkaline pH، ماشي الحال، فكل الـ Hemoglobin تبعه
+
+809
+01:17:34,820 --> 01:17:39,280
+ماشي، Hemoglobin S، يعني ما فيش Hemoglobin A ولا
+
+810
+01:17:39,280 --> 01:17:46,060
+Hemoglobin F اللي بيخفف، وكله Hemoglobin S، تمام؟
+
+811
+01:17:46,060 --> 01:17:49,400
+فالآن السؤال، What is the probability that the
+
+812
+01:17:49,400 --> 01:17:53,800
+unborn child will inherit one or more mutant
+
+813
+01:17:53,800 --> 01:17:57,940
+alleles from his parents؟ فشو هذا الـ Disease يا
+
+814
+01:17:57,940 --> 01:18:03,700
+معتز؟ زي ما مدرّسي يسأل؟ طيب، إذا أقرأ السؤال بشكل
+
+815
+01:18:03,700 --> 01:18:08,700
+دقيق، شو نسبة الـ Probability، الـ unborn child
+
+816
+01:18:08,700 --> 01:18:13,200
+will inherit one or more؟ يعني واحد، يعني ما
+
+817
+01:18:13,200 --> 01:18:17,180
+اثنين، القليل اللي هم الـ mutant، طيب، إذا شو
+
+818
+01:18:17,180 --> 01:18:24,240
+نسبه؟ ثلاثة أرباع، ثلاثة أرباع، هيك المفروض ثلاثة
+
+819
+01:18:24,240 --> 01:18:31,020
+أرباع، ماشي؟ السبب أنه فيه احتمال ربع، هذا تظامن
+
+820
+01:18:31,020 --> 01:18:35,520
+recessive، وإحنا نحكي على الطفل اللي مش مولود لسه
+
+821
+01:18:35,520 --> 01:18:42,280
+لو حكى one قليل mutant بيكون نصف صح؟ لو one قليل
+
+822
+01:18:42,280 --> 01:18:48,700
+only، أه كان لو حكى هيك، بس حكى one or more، لو two
+
+823
+01:18:48,700 --> 01:18:54,140
+قليل برضه بيطلع ربع، لو two قليل بيطلع ربع، صحيح، ماشي
+
+824
+01:18:54,140 --> 01:18:57,880
+أنا مضطر هسا أطلع، أترككم، لإنه عندي تدريس ثاني يا
+
+825
+01:18:57,880 --> 01:19:01,980
+شباب، ماشي، نلتقي يوم الاثنين الجاي إن شاء الله
+
+826
+01:19:01,980 --> 01:19:05,320
+يعطيك ألف عافية يا دكتور، الله يحييكم، الله يحفظكم،
+
+827
+01:19:05,320 --> 01:19:08,540
+أهلين، أهلين، يلا، السلام عليكم، في رعاية الله
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/Y-q_VMv635w_raw.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/Y-q_VMv635w_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..63879c56bdd64ba56cfeeb76b4c2a51f330e05f7
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/Y-q_VMv635w_raw.srt
@@ -0,0 +1,3328 @@
+1
+00:00:00,000 --> 00:00:04,820
+الذين يتعاملون بـ Minor Trauma والدي والدته ليس
+
+2
+00:00:04,820 --> 00:00:12,620
+لديه مشكلة برده طبعا يعني اللي لما نكون عندنا اشي
+
+3
+00:00:12,620 --> 00:00:20,320
+بنقوله يعني bleeding tendency فهي مشكلة في ال
+
+4
+00:00:20,320 --> 00:00:27,280
+bleeding disorder ايه بنسميها او problem with
+
+5
+00:00:27,280 --> 00:00:32,840
+hemostasisالـ Hemostasis يعني اللي هي طريقة
+
+6
+00:00:32,840 --> 00:00:37,280
+استجابة الجهاز الدوري الـ Cardiovascular System
+
+7
+00:00:37,280 --> 00:00:44,820
+لموضوع الـ Injury موضوع حدوث تمزح في الأوعي
+
+8
+00:00:44,820 --> 00:00:49,500
+الدموية في حياته الدم بيصير يطلع فعنا نوعين من الـ
+
+9
+00:00:49,500 --> 00:00:53,820
+Hemostasis فيه Primary Hemostasis وفيه Secondary
+
+10
+00:00:53,820 --> 00:01:00,430
+Hemostasis الـ Primary اللي بيشتغل أولا مباشرةماشي
+
+11
+00:01:00,430 --> 00:01:06,490
+وبكون واحدة من فنتين الـ platelets أو الـ blood
+
+12
+00:01:06,490 --> 00:01:11,110
+vessel response فهدولة بيسموها primary hemostasis
+
+13
+00:01:11,110 --> 00:01:17,850
+ال secondary hemostasis اللي هم نتيجة شغل ال
+
+14
+00:01:17,850 --> 00:01:22,430
+calculation factorفي عندنا الـ Extrinsic Pathway و
+
+15
+00:01:22,430 --> 00:01:25,810
+Intrinsic Pathway وCommon Pathway في الأخير
+
+16
+00:01:25,810 --> 00:01:29,750
+الفيبرينوجين بتحول لفيبرين بأعمل Clot بسكر الـ
+
+17
+00:01:29,750 --> 00:01:33,810
+Blood اللي إنجلت هدولة الـ Primary وSecondary
+
+18
+00:01:33,810 --> 00:01:43,190
+Homostasis ليش حطولكم النقاط هذه دايما سامعيني
+
+19
+00:01:43,190 --> 00:01:46,930
+فاهميني معاي الشباب والكل
+
+20
+00:01:51,290 --> 00:01:56,070
+- Hi كريم، معاك؟ ‏- مرحبًا يا أختي واصلي ‏- طيب،
+
+21
+00:01:56,070 --> 00:02:01,850
+الآن كيف نفرق الـ Primary وSecondary Hemostasis؟ ‏
+
+22
+00:02:01,850 --> 00:02:04,910
+- هذه نقطة بالـ Hematology، المفروض تاخدوها بعدها
+
+23
+00:02:04,910 --> 00:02:10,630
+‏- لدينا أربع Characteristics نفرقها ‏- هل هي
+
+24
+00:02:10,630 --> 00:02:16,910
+Coagulation Factor Problem ‏- ولا الـ
+
+25
+00:02:16,910 --> 00:02:21,950
+Primaryيعني الـ Coagulation Factor و لا الـ Place
+
+26
+00:02:21,950 --> 00:02:25,130
+to Blood Vessel Response Problem الـ Primary و لا
+
+27
+00:02:25,130 --> 00:02:29,210
+الـ Secondary الـ Primary أول شيء بنقوله
+
+28
+00:02:29,210 --> 00:02:34,270
+Superficial يعني عالجين على الإسنان لما واحد يفرش
+
+29
+00:02:34,270 --> 00:02:39,310
+إسنانه لما يكون إشي بيكون سطحي الـ Coagulation
+
+30
+00:02:39,310 --> 00:02:43,930
+Factor Problem بيكون Deep يعني زي هيك في الـ Joint
+
+31
+00:02:43,930 --> 00:02:48,070
+لما يقولك إنه في عنده Joint Problem Joint Swelling
+
+32
+00:02:48,660 --> 00:02:51,720
+وBleeding in the joints هذه بتقول Coagulation
+
+33
+00:02:51,720 --> 00:02:58,120
+Factor هاي واحدة الشغل الثاني الـ Bleeding بعد ال
+
+34
+00:02:58,120 --> 00:03:03,560
+trauma في حالة الـ Primary Hemostasis بيكون
+
+35
+00:03:03,560 --> 00:03:07,460
+Immediate لأنه Immediate الـ Primary يعني لو واحد
+
+36
+00:03:07,460 --> 00:03:11,060
+يكون عنده Platelet ولا عنده Blood Vessel Response
+
+37
+00:03:11,060 --> 00:03:19,190
+Problem بتلاقي مثلا بنجرح على طول بنزلوإذا سكرت
+
+38
+00:03:19,190 --> 00:03:22,850
+عليها ومنعت النزف وعطيت مجال للـ Coagulation
+
+39
+00:03:22,850 --> 00:03:29,650
+Factor يشتغله في الحالة هذه لما تسكر على الجرح لما
+
+40
+00:03:29,650 --> 00:03:33,490
+تشيل إيدك بعدين النزف بوقف، هذا بالـ Primary
+
+41
+00:03:33,490 --> 00:03:38,090
+Hemostasis السبب إن الـ Coagulation Factor كويسة
+
+42
+00:03:38,090 --> 00:03:45,030
+بينما الـ Primary Hemostasis بيكون بالأول الـ
+
+43
+00:03:45,030 --> 00:03:51,450
+Coagulation Factorماشي يعني كتير قصص أشهر واحد كان
+
+44
+00:03:51,450 --> 00:03:56,370
+عنده Hemophilia لـ Coagulation Factor Problem ابن
+
+45
+00:03:56,370 --> 00:04:00,390
+قيصر روسيا كانت بالتورة البلشفية كان عنده
+
+46
+00:04:00,390 --> 00:04:07,730
+Hemophilia هو نفس هذه القصة طفل ذكر كان يقع مثلًا
+
+47
+00:04:07,730 --> 00:04:13,010
+هو يلعب مجرد ما يقع مايكون فيه إشي يعني يكون زي زي
+
+48
+00:04:13,010 --> 00:04:18,660
+غيرهبس بعد 6 ساعات، 8 ساعات، 10 ساعات تصير يبين
+
+49
+00:04:18,660 --> 00:04:23,800
+Big Hematoma فالـ onset of bleeding after trauma
+
+50
+00:04:23,800 --> 00:04:29,040
+is delayed for secondary hemostasis ولمّا تيجي
+
+51
+00:04:29,040 --> 00:04:35,580
+تضغط على المحل النزف وتضغط لك ربع ساعة، تلت ساعة،
+
+52
+00:04:35,580 --> 00:04:41,600
+نص ساعة، لما تشيل إيدك، لأ النزف برجع، ما هو وقته
+
+53
+00:04:42,500 --> 00:04:47,600
+فهذه كلها secondary hemostasis problems من ناحية
+
+54
+00:04:47,600 --> 00:04:54,300
+الأخيرة، اللي هي مبدأ إنه in general إذا familial
+
+55
+00:04:54,300 --> 00:04:59,760
+أو genetic الـprimary hemostasis problems بتكون
+
+56
+00:04:59,760 --> 00:05:05,660
+autosomal dominant زي «بومبلبراند» disease والجروب
+
+57
+00:05:05,660 --> 00:05:10,420
+تبعتها هذه الـhemophilias، فيهم hemophilia A وB
+
+58
+00:05:10,940 --> 00:05:21,380
+بتكون Recessive X-linked Recessive فالسيناريو
+
+59
+00:05:21,380 --> 00:05:26,200
+اللي حاطينه بالأول طفل Male وعنده شكله Secondary
+
+60
+00:05:26,200 --> 00:05:31,700
+Hemostasis Problem وهي كلها ماشي مؤشر على
+
+61
+00:05:31,700 --> 00:05:35,810
+Hemophiliaطبعاً الـ Hemophilia فيه Hemophilia A و
+
+62
+00:05:35,810 --> 00:05:39,830
+Hemophilia B الـ Hemophilia A اللي هو الـ Factor 8
+
+63
+00:05:39,830 --> 00:05:43,830
+Deficiency Hemophilia B اللي هي Factor 9 اللي
+
+64
+00:05:43,830 --> 00:05:48,550
+بيسموها Christmas Disease اللي هي اسم تاني كل هذه
+
+65
+00:05:48,550 --> 00:05:53,650
+المعلومات هيك بتيجي من الأول يعني إنسان أو طفل أو
+
+66
+00:05:53,650 --> 00:06:00,050
+ذكر عنده Hemophilia A هاي الكلام اللي بيبقوا لكي
+
+67
+00:06:00,050 --> 00:06:02,670
+يعني الآن
+
+68
+00:06:04,750 --> 00:06:08,530
+الـ evaluation shows that the patient has
+
+69
+00:06:08,530 --> 00:06:12,710
+inherited disorders and that one of his parents is
+
+70
+00:06:12,710 --> 00:06:19,110
+a genetic carrier طبعا يعني هنا هاي لو كان
+
+71
+00:06:19,110 --> 00:06:26,510
+autosomal recessive ما بتثبت كان لازم يكون both
+
+72
+00:06:26,510 --> 00:06:32,650
+his parents are recessive are carriers ماشيفهذه
+
+73
+00:06:32,650 --> 00:06:36,570
+إلا تكون X-linked recessive والـ Career بالـ
+
+74
+00:06:36,570 --> 00:06:45,790
+Parents هي الأم، ماشي؟ أسا عنده أخت who does not
+
+75
+00:06:45,790 --> 00:06:53,290
+have this condition is pregnant يعني أسا أخته يعني
+
+76
+00:06:53,290 --> 00:07:01,090
+الـ Hallmark دائما بنقول أو العلام المميزةللـ X
+
+77
+00:07:01,090 --> 00:07:08,790
+-linked recessive أن الطفل أو أخواله هما المصابين،
+
+78
+00:07:08,790 --> 00:07:16,630
+ماشي؟ فيعني إذا بدك تشوف إنسان إذا هو عنده زي
+
+79
+00:07:16,630 --> 00:07:21,130
+أخواله إذا ولدوا أخواله، هي typical X-linked
+
+80
+00:07:21,130 --> 00:07:30,200
+recessive فالآن الأخت حاملأخت المصاب ماشي هي اللي
+
+81
+00:07:30,200 --> 00:07:39,080
+جاي تسأل وهي ما بتعرف اللي ببطنها ولد ولا بنت ماشي
+
+82
+00:07:39,080 --> 00:07:43,100
+she asked about the risk of her child will be
+
+83
+00:07:43,100 --> 00:07:45,600
+affected which of the following is the best
+
+84
+00:07:45,600 --> 00:07:52,400
+estimate of this child will have the disease ماشي
+
+85
+00:07:52,400 --> 00:07:54,580
+الآن
+
+86
+00:07:57,040 --> 00:08:01,600
+يعني مبدأ في حل الأسئلة اللي زي هيك أو في التعامل
+
+87
+00:08:01,600 --> 00:08:07,880
+مع هذا السؤال لما يجيك من بني آدم ماشي، بنحطه على
+
+88
+00:08:07,880 --> 00:08:14,800
+طريقين اللي هم يا إما أنا بكون متأكد وعارف
+
+89
+00:08:14,800 --> 00:08:24,690
+وبالتالي بعطي نسب محددة أو إذا مش متأكد، ماشيبدي
+
+90
+00:08:24,690 --> 00:08:29,870
+أسوي اللي بيسموهم الـ Conditional Probability واضح
+
+91
+00:08:29,870 --> 00:08:34,150
+يا كريم؟ الله يرضى عليك سامعيني؟ فاهميني إيه؟ شو
+
+92
+00:08:34,150 --> 00:08:39,550
+اللي بحكي؟ تمام يا دكتور، كل موجود يعني أو في عدد
+
+93
+00:08:39,550 --> 00:08:43,050
+موجود يعني غير كريم كمان موجودين أه، كتبين سبعة
+
+94
+00:08:43,050 --> 00:08:46,930
+اللي موجود أنا وياك يعني خمس غيره أنا فاهم إن اللي
+
+95
+00:08:46,930 --> 00:08:52,070
+طرح السؤال يكون فاهمهو الدكتورة «كارميل» هي اللي
+
+96
+00:08:52,070 --> 00:08:58,890
+طرحت السؤال يعني موجودة؟ صحيح صحيح صحيح موجودة
+
+97
+00:08:58,890 --> 00:09:04,730
+طيب، هسا كارميل كيف
+
+98
+00:09:04,730 --> 00:09:14,070
+بدنا نرد على إجابة السؤال هذا؟ الآن أنا الـ
+
+99
+00:09:14,070 --> 00:09:16,810
+Genotype يعني شو
+
+100
+00:09:19,740 --> 00:09:27,620
+الطفل المصاب أكيد عنده X-Chromosome مصاب الـ X
+
+101
+00:09:27,620 --> 00:09:32,160
+-Chromosome عنده مصاب الـ Y مافيش فيه إشي، صح؟
+
+102
+00:09:32,160 --> 00:09:38,600
+فبالتالي أخذوا من يا أبوه يا أمه الـ X هذا، ماشي؟
+
+103
+00:09:39,110 --> 00:09:46,450
+لو كان أبوه حكوا عنه مصاب يبقى ممكن أخذوا منه بس
+
+104
+00:09:46,450 --> 00:09:54,030
+الـ X بتكون من الـ يعني في الحالة هذه بتكون من
+
+105
+00:09:54,030 --> 00:10:01,750
+الأم والأم، أم الطفل هذا المصاب شو اسمه؟ هي الـ
+
+106
+00:10:01,750 --> 00:10:08,270
+Carrier لأنهم اثنينهم Healthy والطفل هذا هو المصاب
+
+107
+00:10:08,810 --> 00:10:13,810
+فكام بدأ أسوي الاحتمالات للسؤال اللي بيسألونياه
+
+108
+00:10:13,810 --> 00:10:20,390
+أخت الطفل هذا الأكبر منه صارت حامل وشافت أخوها
+
+109
+00:10:20,390 --> 00:10:26,670
+عنده مشكلة الـ hemophilia وإنه بنزل وإنه في عنده
+
+110
+00:10:26,670 --> 00:10:30,770
+مشاكل فخايفة على بطنها أو بدأت تتأكد بالنسبة
+
+111
+00:10:30,770 --> 00:10:41,860
+لبطنها شو احتمالاته ماشي ال .. ال ..هذه ما يسمى
+
+112
+00:10:41,860 --> 00:10:45,020
+النسب
+
+113
+00:10:45,020 --> 00:10:48,800
+اللي حاطينها عشر أو تمانية أو تسعة أو عشرين أنا
+
+114
+00:10:48,800 --> 00:10:53,980
+هذه خربطتني شوية هذه نسبة اللي جاوبوا هيك ماشي
+
+115
+00:10:53,980 --> 00:10:59,300
+مانعش أدخل بيها هو أنا بحطه النسبة صفر أو نص أو
+
+116
+00:10:59,300 --> 00:11:02,460
+ربع أو ثمن أو ستة واحدة أو ستاشر أو واحدة أو أثنين
+
+117
+00:11:02,460 --> 00:11:10,410
+وثلاثين كيف بدا نوقلها الآن السؤال الأولالأم اللي
+
+118
+00:11:10,410 --> 00:11:19,910
+هي البنت اللي هي حامل الآن اللي جاي تسأل «ماشي، شو
+
+119
+00:11:19,910 --> 00:11:25,270
+احتمالاتها بالنسبة للمرض هذا؟» «والحالي هذا؟» «مين
+
+120
+00:11:25,270 --> 00:11:34,190
+بيقدر يجاوب؟» قبل ما نشوف كيف تجاوبوها يا
+
+121
+00:11:34,190 --> 00:11:39,620
+إما هتكون health يا إما هتكون careerالنسبة كام لكل
+
+122
+00:11:39,620 --> 00:11:51,100
+واحدة؟ ربع طبعاً كيف ربع؟ نص المشهومة للأم الأصلية
+
+123
+00:11:51,100 --> 00:11:55,340
+career والأب healthy طيب ماني أعمل احتمالات،
+
+124
+00:11:55,340 --> 00:12:00,100
+هيطلع؟ أنا بحكي عن البنت اللي حامل اللي هي الآن لو
+
+125
+00:12:00,100 --> 00:12:05,500
+ترسم ال degree هي اللي جاية تسأل و عندها pregnancy
+
+126
+00:12:05,500 --> 00:12:11,550
+هي الأم المرأة الحاملهسا، شو احتمالات عندها الجين
+
+127
+00:12:11,550 --> 00:12:19,890
+المصاب؟ نص الإناث، نص بتكون نص، يعني نص الحالة، شو
+
+128
+00:12:19,890 --> 00:12:28,630
+اسمها؟ نص الحالة بكون فيها، عندها إصابة، آسف، نص
+
+129
+00:12:28,630 --> 00:12:33,250
+الحالات بتكون هي career ونص الحالات ممكن تكون
+
+130
+00:12:33,250 --> 00:12:40,820
+completely healthy، صح؟ تمام، صحيحكداش احتمالات أن
+
+131
+00:12:40,820 --> 00:12:50,480
+البطنها ولد ولا بنت؟ كمان نص بنص نص نص نص نص نص نص
+
+132
+00:12:50,480 --> 00:12:51,520
+نص نص نص نص نص نص نص نص نص نص نص نص نص نص نص نص نص
+
+133
+00:12:51,520 --> 00:12:52,820
+نص نص نص نص نص نص نص نص نص نص نص نص نص نص نص نص نص
+
+134
+00:12:52,820 --> 00:12:55,440
+نص نص نص نص نص نص نص نص نص نص نص نص نص نص نص نص نص
+
+135
+00:12:55,440 --> 00:12:59,440
+نص نص نص نص نص نص نص نص نص نص نص نص نص نص نص نص نص
+
+136
+00:12:59,440 --> 00:12:59,440
+نص نص نص نص نص نص نص نص نص نص نص نص نص نص نص نص نص
+
+137
+00:12:59,440 --> 00:12:59,520
+نص نص نص نص نص نص نص نص
+
+138
+00:13:08,490 --> 00:13:16,030
+الحمل اللي بطن المرأة هذه أو البنت هذه نص نص إنها
+
+139
+00:13:16,030 --> 00:13:20,150
+تكون مصابة مصابة؟ ماعرفش احتمال إنها تكون مصابة
+
+140
+00:13:20,150 --> 00:13:28,470
+لأنه فيه احتمال نص إنه تكون carrier ماشي ونص تاني
+
+141
+00:13:28,470 --> 00:13:33,990
+إنه لأنه ما جاب حصيرة إنهالجوز المرة هذه أو الطفل
+
+142
+00:13:33,990 --> 00:13:40,950
+البنت هذه اللي يعني أخت المصاب ما جابه سيرة إنه
+
+143
+00:13:40,950 --> 00:13:47,550
+مصاب كمان صحيح فهسا لو كانت بنت فاحتمالية إنها
+
+144
+00:13:47,550 --> 00:13:56,070
+تكون مصاب صفر، صح؟ ولو طلع ولد، شو نسبت إنه يكون
+
+145
+00:13:56,070 --> 00:14:04,270
+مصاب؟أخد الـ X المصاب يعني نص برضه نص نص صح؟ صحيح
+
+146
+00:14:04,270 --> 00:14:13,210
+فإن انت تاخد إنه هي كالبنت
+
+147
+00:14:13,210 --> 00:14:19,470
+العامل هذه أخت الولد المصاب أول شيء هي احتمالها نص
+
+148
+00:14:19,470 --> 00:14:26,470
+إنه تكون هي career أي واحدة يعني عندها one copyوفي
+
+149
+00:14:26,470 --> 00:14:31,650
+احتمال نص أن يكون بنت وبالتالي ما في احتمال أن
+
+150
+00:14:31,650 --> 00:14:37,830
+يكون مصابر ولو كان ولد الاحتمال نص فنص بنص بنص بنص
+
+151
+00:14:37,830 --> 00:14:45,450
+بيطلع ثمن فالإجابة ثمن واضحة يعني هنا بدنا نطبق
+
+152
+00:14:45,450 --> 00:14:51,530
+إشي من كله conditional probability ماشي بقول ال
+
+153
+00:14:54,060 --> 00:15:00,900
+اللي هي المرأة الحامل هذه الأم اللي هنا بالحالة
+
+154
+00:15:00,900 --> 00:15:07,300
+الجيل الثاني أخت المصاب أول شيء في احتمال نص أنه
+
+155
+00:15:07,300 --> 00:15:13,100
+تكون career ونص أنها تكون normal وبعدين احتمال أنه
+
+156
+00:15:13,100 --> 00:15:19,940
+يكون ذكر ولا أنثىاللي باطنها، ما بنعرف لسه، لو
+
+157
+00:15:19,940 --> 00:15:25,080
+بعرف أنه ذكر بقول لأ الاحتمال بصير ربع، ماشي، لو
+
+158
+00:15:25,080 --> 00:15:29,260
+بعرف أنه ذكر، بس أنا ما بعرف أنه ذكر، فيمكن ذكر،
+
+159
+00:15:29,260 --> 00:15:32,660
+يمكن أنثى، لو هيك بتيجي بتسألني بالوجه، شو
+
+160
+00:15:32,660 --> 00:15:36,620
+احتمالية أنه يكون مصاب، بقول واحد على ثمانية،
+
+161
+00:15:36,620 --> 00:15:39,380
+واضحة الحال كيف؟ اللي بيسموها conditional
+
+162
+00:15:39,380 --> 00:15:46,370
+probability، يعني أنا بصير أحطحسب الشروط مجموع
+
+163
+00:15:46,370 --> 00:15:51,990
+الحلال مجموع النسب لازم يوصل واحد لأن كل
+
+164
+00:15:51,990 --> 00:15:58,630
+الاحتمالات راح تكون واحد، ماشي؟ فلما تيجيني امرأة
+
+165
+00:15:58,630 --> 00:16:03,230
+هيك زي هيك أخوها مصاب، هي حامل، هي مش عارفة شو
+
+166
+00:16:03,230 --> 00:16:06,830
+اللي عندها بتقوللي شو نسبة احتمالية ان البطن يطلع
+
+167
+00:16:06,830 --> 00:16:11,650
+مصاب، بقولها واحد ع ثمانين، هيك بدها تيجي، ماشي؟
+
+168
+00:16:12,100 --> 00:16:18,160
+فنشوف شو ال .. ال .. هنا هذا السؤال يعني فيه ناس
+
+169
+00:16:18,160 --> 00:16:23,060
+خربطوا في الرُبع فيه ناس حطوا نص فهسة هنا يعني هاي
+
+170
+00:16:23,060 --> 00:16:31,040
+برسمونا المثال اللي احنا اتكلمنا عنه ال .. هاي
+
+171
+00:16:31,040 --> 00:16:39,420
+الاجدود الأم أكيد لازم تكون career الأبو حكوا عنه
+
+172
+00:16:39,420 --> 00:16:49,370
+سليم مافي مشكلةالولد المصاب عنده جين مصاب ماشي في
+
+173
+00:16:49,370 --> 00:16:54,950
+الـ X و X-linked recessive فهيبين عليه فهذه البنت
+
+174
+00:16:54,950 --> 00:17:01,070
+هي اللي أجت تسأل وبتسأل على إنها عندها حمل وبدأت
+
+175
+00:17:01,070 --> 00:17:06,990
+تعرف قداش نسبته ففي احتمال النص إنها تكون Normal
+
+176
+00:17:06,990 --> 00:17:13,560
+ونص إنه يكون Carrierفي احتمال النُص أن يكون ولد
+
+177
+00:17:13,560 --> 00:17:22,440
+وفي احتمال نُص يكون بنت واحتمال الولد نُص كمان أنه
+
+178
+00:17:22,440 --> 00:17:28,020
+يطلع مصاب ونُص أنه يطلع طبيعي فالثلاث نُص بنُص
+
+179
+00:17:28,020 --> 00:17:31,800
+بنُص ويطلع واحد على ثمانية، هيك الإجابة الصحيحة في
+
+180
+00:17:31,800 --> 00:17:33,920
+أسئلة، إن شاء الله وضحكت هيك الأمور
+
+181
+00:17:37,880 --> 00:17:42,620
+يعني اللي حاطينها الـ B1 الـ Parents أو اللي هي
+
+182
+00:17:42,620 --> 00:17:47,600
+هذه أم المرأة الحامل عندها 50% نسبة إنها تكون
+
+183
+00:17:47,600 --> 00:17:54,760
+Career عندها نسبة 50% تعطي أولادها وبناتها الجين
+
+184
+00:17:54,760 --> 00:18:01,330
+المصاب وإذا عشان يكون مصاب لازم يكون Maleما بنفعل
+
+185
+00:18:01,330 --> 00:18:04,210
+«the female» «the female» راح تطلع career زي إذا
+
+186
+00:18:04,210 --> 00:18:09,290
+كانت أمها مصابة يعني حامل الجين يعني فنص و نص و نص
+
+187
+00:18:09,290 --> 00:18:18,290
+بطلع 81 أتأمل أنها تكون واضحة في أسئلة ثانية؟ بدكم
+
+188
+00:18:18,290 --> 00:18:25,190
+هيك رقم سؤال ناخده؟
+
+189
+00:18:25,190 --> 00:18:31,820
+في سؤال رقم جديد في «blogball»فان فكرته بيحكي عن
+
+190
+00:18:31,820 --> 00:18:43,380
+«هارفيند» أو «هارفيند» بيحكي
+
+191
+00:18:43,380 --> 00:18:44,820
+عن «هارفيند» أو «هارفيند» بيحكي عن «هارفيند» بيحكي
+
+192
+00:18:44,820 --> 00:18:45,120
+عن «هارفيند» بيحكي عن «هارفيند» بيحكي عن «هارفيند»
+
+193
+00:18:45,120 --> 00:18:46,000
+بيحكي عن «هارفيند» بيحكي عن «هارفيند» بيحكي عن
+
+194
+00:18:46,000 --> 00:18:46,060
+«هارفيند» بيحكي عن «هارفيند» بيحكي عن «هارفيند»
+
+195
+00:18:46,060 --> 00:18:53,380
+بيحكي عن «هارفيند» بيحكي عن «هارفيند»
+
+196
+00:18:53,380 --> 00:18:58,800
+بيحكي عن «هارفيند» بيحكي عن «هارفيند» بيحكي عن «
+
+197
+00:19:01,690 --> 00:19:06,090
+السؤال اللي جاب ليه اللي جاب ليه طيب خلينا نشوف
+
+198
+00:19:06,090 --> 00:19:11,390
+طيب
+
+199
+00:19:11,390 --> 00:19:22,090
+خلينا نشوف بدك كريم اقرأ السؤال خلينا نشوف واضح
+
+200
+00:19:22,090 --> 00:19:22,970
+عندك السؤال؟
+
+201
+00:19:32,830 --> 00:19:38,470
+كريم أو أي حد ثاني
+
+202
+00:19:38,470 --> 00:19:54,970
+مش
+
+203
+00:19:54,970 --> 00:20:00,290
+عارف، بحب انتم تشاركوا معاه يعني بس مش أنا أقعد
+
+204
+00:20:00,290 --> 00:20:09,360
+أتكلم إذاما اسمه؟ إذا مرات واضح، مش واضح، نشوفه A
+
+205
+00:20:09,360 --> 00:20:14,640
+31-year-old woman comes to the office as she and
+
+206
+00:20:14,640 --> 00:20:20,140
+her husband desire a second child ماشي؟ The
+
+207
+00:20:20,140 --> 00:20:26,920
+husband is infertile and the patient's son who was
+
+208
+00:20:26,920 --> 00:20:31,640
+conceived via donor inseminationكانت مؤكدًا
+
+209
+00:20:31,640 --> 00:20:37,180
+بـGlycogen Storage Disease Type 2 اللي هو
+
+210
+00:20:37,180 --> 00:20:42,420
+الـBombay Disease الأن
+
+211
+00:20:42,420 --> 00:20:49,580
+هؤلاء الـMetabolic Disorders، ما هو اسمه؟ أيش
+
+212
+00:20:49,580 --> 00:20:53,680
+الـInheritance تبعتهم؟ يعني هو أنا كويس في الأسئلة
+
+213
+00:20:53,680 --> 00:20:59,290
+هذهحتى بأعطيك تعليم، يعني شو فيه بعض المعلومات على
+
+214
+00:20:59,290 --> 00:21:02,350
+الأقل لأنه مش متوقع أنك أنت بتعرفوا أو سمعت فيها
+
+215
+00:21:02,350 --> 00:21:05,870
+The Bombay's Disease Glycogen Storage Disease
+
+216
+00:21:05,870 --> 00:21:13,330
+بيكون Hepatosplenomegaly بيكون Decreased Oxygen أو
+
+217
+00:21:13,330 --> 00:21:19,910
+يعني قوة العضلات أضعف وضعف وكده وعادة مشكلة كبيرة
+
+218
+00:21:21,520 --> 00:21:27,080
+هذه مصابة عادية لـ Autosomal Recession معروفة
+
+219
+00:21:27,080 --> 00:21:35,660
+لتأثير واحد في أربعين ألف في المجتمع العام ماشي،
+
+220
+00:21:35,660 --> 00:21:42,260
+شو بنستفيد من هذا الكلام؟ مين يجاوبني؟ كل واحد من
+
+221
+00:21:42,260 --> 00:21:46,540
+أربعين ألف مصاب،
+
+222
+00:21:46,540 --> 00:21:53,550
+أيوة كريمنعم تقدر تطلع الـ «Q» اللي هو الـ «points
+
+223
+00:21:53,550 --> 00:22:02,610
+of rest of the قليل» طبعا، تمام، كم بتطلع؟ بتجيب
+
+224
+00:22:02,610 --> 00:22:07,970
+الـ «square root» للـ 40 ألف هاد وبيطلع واحد على
+
+225
+00:22:07,970 --> 00:22:14,210
+ميتين واحد على ميتين، تمام، ماشي، فيعني هسة في
+
+226
+00:22:14,210 --> 00:22:25,890
+معلومات أخدناهاالقصة اللي بيحكوها هنا أن الزلمة
+
+227
+00:22:25,890 --> 00:22:32,310
+يعني هدول ال couple هدول الزوجين عملوا شغل بدهم
+
+228
+00:22:32,310 --> 00:22:40,870
+يخلفوا الزلمة مافيش endosperm و بيخلفش فراحت هي مع
+
+229
+00:22:40,870 --> 00:22:46,370
+زوجها راحوا على تبعين اللي بيعملوااللي هو التلقيح
+
+230
+00:22:46,370 --> 00:22:51,150
+بالأنبيب أو زراعة أنبيب للأطفال لزراعة الأطفال
+
+231
+00:22:51,150 --> 00:22:58,150
+بالأنبيب وأخذت حيوان منوي من أي واحد من الـ
+
+232
+00:22:58,150 --> 00:23:05,310
+General population السائلين وأجت الطفل اللي ولدته
+
+233
+00:23:05,310 --> 00:23:10,910
+بهذه الطريقة عنده هذه الإصابة المرض النادر هذا طلع
+
+234
+00:23:10,910 --> 00:23:17,680
+الطفل المصابماشي، فهذه قصتها Genetic
+
+235
+00:23:17,680 --> 00:23:21,660
+Testing Confirms That The Patient Is A Carrier For
+
+236
+00:23:21,660 --> 00:23:27,460
+The Disease طلعت الجين المصاب هو في ال .. كنسبة
+
+237
+00:23:27,460 --> 00:23:34,480
+الأليل في ال population واحد على ميتين فالإصابة
+
+238
+00:23:34,480 --> 00:23:40,680
+بتكون واحد في الأربعين ألف اللي هي Q تربيع ماشي
+
+239
+00:23:42,480 --> 00:23:50,600
+الآن ما ستفعل؟ هي Carrier فإنه
+
+240
+00:23:50,600 --> 00:23:57,860
+الأول طلع بهذا الشكل معناته إنه نصيبهم إن الشخص
+
+241
+00:23:57,860 --> 00:24:03,280
+الثاني اللي أخذوا منه بشكل عمياني
+
+242
+00:24:03,280 --> 00:24:11,270
+الـ Spare طلع عنده الـ Carrier للجين هذاوبالتالي
+
+243
+00:24:11,270 --> 00:24:14,330
+autosome-recessive فواحد من هذا الـ 40 ألف طلع
+
+244
+00:24:14,330 --> 00:24:18,950
+بهذا الطفل اللي عنده بالأول a different sperm
+
+245
+00:24:18,950 --> 00:24:22,770
+donor is selected with no personal or family
+
+246
+00:24:22,770 --> 00:24:27,210
+history of Bombay disease however his career
+
+247
+00:24:27,210 --> 00:24:31,550
+status is unknown فقرروا المرة الثانية بيعدوا نفس
+
+248
+00:24:31,550 --> 00:24:36,330
+الشغل بس المرة هذه قالوا خلينا ناخد حد ثاني فاخدوا
+
+249
+00:24:36,330 --> 00:24:41,790
+شخص آخربس برضه مش جادرين يكونوا متأكدين إنه ما
+
+250
+00:24:41,790 --> 00:24:45,510
+عنده المرض وفي الغالب اللي بتبرع بهذه الشغلات يكون
+
+251
+00:24:45,510 --> 00:24:49,830
+يفترض إنه هيك على الأقل مظهريًا إنه إنسان سليم
+
+252
+00:24:49,830 --> 00:24:57,990
+وطبيعي وكذا وكذلك يعني، ماشي؟ So، الآن السؤال What
+
+253
+00:24:57,990 --> 00:25:02,350
+is the probability of the patient having an
+
+254
+00:25:02,350 --> 00:25:10,500
+affected child with the new sperm donor؟الأن الأم
+
+255
+00:25:10,500 --> 00:25:19,100
+اللي هي هاي بتسأل هي أكيد إيش؟ مصابة ولا career
+
+256
+00:25:19,100 --> 00:25:24,960
+ولا طبيعي؟ ‏- career ‏- لازم تكون career، صح؟ ‏-
+
+257
+00:25:24,960 --> 00:25:29,020
+لازم تكون career ‏- لازم تكون career ‏- لازم تكون
+
+258
+00:25:29,020 --> 00:25:30,620
+career ‏- لازم تكون career ‏- لازم تكون career ‏-
+
+259
+00:25:30,620 --> 00:25:30,800
+لازم تكون career ‏- لازم تكون career ‏- لازم تكون
+
+260
+00:25:30,800 --> 00:25:30,800
+career ‏- لازم تكون career ‏- لازم تكون career ‏-
+
+261
+00:25:30,800 --> 00:25:30,800
+لازم تكون career ‏- لازم تكون career ‏- لازم تكون
+
+262
+00:25:30,800 --> 00:25:30,840
+career ‏- لازم تكون career ‏- لازم تكون career ‏-
+
+263
+00:25:30,840 --> 00:25:30,840
+لازم تكون career ‏- لازم تكون career ‏- لازم تكون
+
+264
+00:25:30,840 --> 00:25:35,160
+career ‏- لازم تكون career ‏-
+
+265
+00:25:38,190 --> 00:25:42,610
+مش لسه بدي أدرس أو كده لأنه هذا autism and
+
+266
+00:25:42,610 --> 00:25:48,830
+recessive وفيه طفل مصاب إذن الأم والأب الحقيقي
+
+267
+00:25:48,830 --> 00:25:52,730
+أثنينهم لازم يكونوا career ما بيصير يعني ما راح
+
+268
+00:25:52,730 --> 00:25:58,170
+يطلع autism and recessive ومافيش career يعني أو
+
+269
+00:25:58,170 --> 00:26:02,310
+واحد بس اللي career لازم أثنين career فالآن
+
+270
+00:26:02,310 --> 00:26:05,510
+الحكينا
+
+271
+00:26:05,510 --> 00:26:13,900
+الأمشو احتمالية إنها تعطي الجين الأليل المصاب؟ هي
+
+272
+00:26:13,900 --> 00:26:22,880
+career إذا الاحتمال إيش؟ نص وجابوا sperm جديد من
+
+273
+00:26:22,880 --> 00:26:27,500
+الـGeneral population فداش احتمالية إنه يكون حامل
+
+274
+00:26:27,500 --> 00:26:34,640
+للجين تبع المرض؟ اللي هي الـQ اللي طلعناها من الـQ
+
+275
+00:26:34,640 --> 00:26:40,550
+تربيع اللي معطينيهاهو الـ Spare Donor مش راح يكون
+
+276
+00:26:40,550 --> 00:26:44,870
+affected لإنه كان لك حينورمال في 2020 –شو احتمالية
+
+277
+00:26:44,870 --> 00:26:53,730
+إن الـ Spare Donor يطلع career أو قداش الاحتمالية
+
+278
+00:26:53,730 --> 00:26:58,030
+1 على 200 لأن هذا احتمالية –إن السنة كانت من الـQE
+
+279
+00:26:58,030 --> 00:26:59,170
+–نعم
+
+280
+00:27:10,530 --> 00:27:13,690
+الـ Spare بما أنه من الـ General Population
+
+281
+00:27:13,690 --> 00:27:21,090
+احتمالية إنه يكون القليل هو المصاب واحد على ميتين
+
+282
+00:27:21,090 --> 00:27:26,870
+فاحنا بالنسبة
+
+283
+00:27:26,870 --> 00:27:34,310
+للقصة هذه والسلافة بهذه الطريقة ماشي بتقول الـ
+
+284
+00:27:34,310 --> 00:27:39,290
+General Population إنه يطلع careerونعطينا القليل
+
+285
+00:27:39,290 --> 00:27:44,370
+المصاب 1 في الميتين والمرأة هذه أنا متأكد إنها
+
+286
+00:27:44,370 --> 00:27:50,270
+Carrier فاحتمالية أن تعطينا الـ Affected قليل هو
+
+287
+00:27:50,270 --> 00:27:57,330
+نص فنص 1 على 200 بيطلع 1 على 400 فإجابتي راح تكون
+
+288
+00:27:57,330 --> 00:28:03,610
+1 على 400 لما تشوفوا الإجابة بكتبوا 1 على 400
+
+289
+00:28:03,610 --> 00:28:05,550
+ماشي؟
+
+290
+00:28:08,700 --> 00:28:14,040
+إن شاء الله واضحة كريم
+
+291
+00:28:14,040 --> 00:28:19,340
+يبدو أنه واضح السؤال، فيه نقطة أنت بدك تسأل عنها
+
+292
+00:28:19,340 --> 00:28:25,300
+في المعادلة نفسها؟
+
+293
+00:28:25,300 --> 00:28:31,590
+لأ لأ تمام، أنا بس حاطط السؤال، السؤال واضحالسؤال
+
+294
+00:28:31,590 --> 00:28:36,270
+يعني إحنا دائماً نتذكر يعني أنا بعتبر هدولة الـ
+
+295
+00:28:36,270 --> 00:28:40,490
+«ثلاث معادلات» اللي ناتج عن «هاردي وانبرج»
+
+296
+00:28:40,490 --> 00:28:45,730
+Analysis لازم لوحدك يحفظهم وإذا بدي إيجي بدك تدور
+
+297
+00:28:45,730 --> 00:28:50,130
+عليهم زي ما سوينه هنا لما يجيني يعطيني
+
+298
+00:28:50,130 --> 00:28:59,270
+الـPrevalence أو مدى انتشار المرض اللي هو الـQ
+
+299
+00:28:59,270 --> 00:29:05,460
+تربيعالـ frequency of the disease individual
+
+300
+00:29:05,460 --> 00:29:10,400
+نسبتهم high لـ Q تربية إذاً الـ frequency تبعت
+
+301
+00:29:10,400 --> 00:29:16,640
+الأليل تخلط جدر فهذه أعطاني نسبة احتمالية أنه يكون
+
+302
+00:29:16,640 --> 00:29:21,180
+الواحد carrier لهذا الـ rare disease هنا واحد على
+
+303
+00:29:21,180 --> 00:29:29,090
+ميتين والأم في الحالة هذه أنا متأكد نص لأنهاعندها
+
+304
+00:29:29,090 --> 00:29:35,710
+هي لازم تكون career فالحال الأولى هيك نصيبة أنه
+
+305
+00:29:35,710 --> 00:29:39,970
+منها المتين ال individual اللي أخدت منه ال spare
+
+306
+00:29:39,970 --> 00:29:44,950
+كان كمان career يعني هاي لو كانت يعني زي ما نقول
+
+307
+00:29:44,950 --> 00:29:50,430
+اتجوزته فأسا عندها خيار ثاني بدأ تغير وجابت إنسان
+
+308
+00:29:50,430 --> 00:29:57,940
+ثاني يظلفي قضية الاحتمالات إنه إذا صار إشي أول مرة
+
+309
+00:29:57,940 --> 00:30:02,800
+مش بالضرورة إنه يصير المرة الثانية كل حمل إشي
+
+310
+00:30:02,800 --> 00:30:08,520
+منفصل والنسب بتظلها ثابتة دا نفس الأباء يعني فهنا
+
+311
+00:30:08,520 --> 00:30:14,760
+واحد ثاني برضه واحد على متين فهي الاحتمالية نصف
+
+312
+00:30:14,760 --> 00:30:20,020
+فبتصير واحد على أربعمية فهيك بتمشي الأمور ماشي في
+
+313
+00:30:20,020 --> 00:30:20,840
+أسئلة أخرى
+
+314
+00:30:27,340 --> 00:30:33,120
+إذا حد بالـChat عنده استفسار على سؤال آخر، نشوف
+
+315
+00:30:33,120 --> 00:30:36,280
+الـChat، آه
+
+316
+00:30:41,500 --> 00:30:45,760
+دكتور إذا الأسئلة اللي أنت حكيت إنه فيها الـ Stop
+
+317
+00:30:45,760 --> 00:30:54,220
+Codons اللي هي EATT والـ CATT هذه اللي ما .. يعني
+
+318
+00:30:54,220 --> 00:30:58,240
+ما ركزت أنت عليها في الاشياء؟ لأ أنا .. أنا الفكرة
+
+319
+00:30:58,240 --> 00:31:02,000
+يعني إذا قريت السؤال اللي جابة هايش الأسئلة على
+
+320
+00:31:02,000 --> 00:31:07,900
+هذه النقطة يعني هي الـ trick اللي فيها إنك أنت
+
+321
+00:31:07,900 --> 00:31:14,560
+تنتبه إذاالـ Codon لـ Amino Acid في النُص، في نُص
+
+322
+00:31:14,560 --> 00:31:21,360
+البروتين، اتحول لـ Stop Codon، شو رح يصير؟ هلية
+
+323
+00:31:21,360 --> 00:31:26,140
+بناء البروتين رح توقف، فراح يبقى لك البروتين
+
+324
+00:31:26,140 --> 00:31:30,460
+الناتج، هو بيقولك البروتين الناتج قصير، البروتين
+
+325
+00:31:30,460 --> 00:31:37,380
+الناتج مش مظبوط، والسبب أن هاي اتغيرت لهاي، فاهم
+
+326
+00:31:37,380 --> 00:31:42,640
+عليك كيف؟ففي الحالة هذه لما نشوف إنه كتاب لك يعني
+
+327
+00:31:42,640 --> 00:31:48,880
+هظهرني هذا السؤال الثاني أو الثالث خلّينا يعني
+
+328
+00:31:48,880 --> 00:31:56,900
+أشوف يعني أنا استغربت يعني هم الكتب بتتكلم على
+
+329
+00:31:56,900 --> 00:32:01,600
+أشياء مختلفة يعني فيه مرات
+
+330
+00:32:04,070 --> 00:32:09,350
+يعني الـ Diseases ولا كده اللي بيشرحوا عنه هي
+
+331
+00:32:09,350 --> 00:32:15,530
+بتعطيك فكرة ولا هذي
+
+332
+00:32:15,530 --> 00:32:23,410
+بس لـGen دقيقة خلّيني أطلّق السؤال، إيش اسمه؟ اللي
+
+333
+00:32:23,410 --> 00:32:28,370
+هو إنه عن الـAlternative Splicing
+
+334
+00:32:35,100 --> 00:32:41,880
+أنا هسا بدنا نروح ندور على السؤال بس لما نكون أنه
+
+335
+00:32:41,880 --> 00:32:46,180
+يعني بهو بصفلك يعني الـ… الـ… الـ… الكويس في
+
+336
+00:32:46,180 --> 00:32:51,060
+الأسئلة هذولة صراحة كقالية الدراسة أن نفسي استم
+
+337
+00:32:51,060 --> 00:32:56,360
+السؤال هو هتطلق معلومات يعني أنا هسا مثلا شرحنا
+
+338
+00:32:56,360 --> 00:33:02,150
+موضوع الـHemophilia بشكلأكتر شوية أنا مش قصدي هذا
+
+339
+00:33:02,150 --> 00:33:05,690
+أن نكون hematology lecture يعني إحنا هذه المفروض
+
+340
+00:33:05,690 --> 00:33:08,670
+تاخدوها بالـ hematology إحنا بدأنا نركز على الـ
+
+341
+00:33:08,670 --> 00:33:14,670
+genetics فالـ genetics يعني simple وهي هذه ال
+
+342
+00:33:14,670 --> 00:33:21,490
+rules تبعتها بحيث أنه لما نشوف الكلام اللي كاتبينه
+
+343
+00:33:21,490 --> 00:33:27,750
+بهذه الطريقة شو اسمه؟ طيب
+
+344
+00:33:28,700 --> 00:33:38,680
+هذا أظن السؤال الثامن، ولا لأ؟ يعني
+
+345
+00:33:38,680 --> 00:33:43,200
+الأسئلة، استم الأسئلة صراحة دكتور أحمد، فيها
+
+346
+00:33:43,200 --> 00:33:49,660
+معلومات مفيدة، يعني أنت تخيلتها وكذا، بتلاقيك، و
+
+347
+00:33:49,660 --> 00:33:51,920
+بتستخدم، شو اسمه؟
+
+348
+00:33:56,640 --> 00:33:59,860
+المحققين يقومون بإزالة عيوب البشر ويقومون بإزالة
+
+349
+00:33:59,860 --> 00:34:01,120
+مصدر RNA محدث محدث محدث محدث محدث محدث محدث محدث
+
+350
+00:34:01,120 --> 00:34:02,480
+محدث محدث محدث محدث محدث محدث محدث محدث محدث محدث
+
+351
+00:34:02,480 --> 00:34:03,120
+محدث محدث محدث محدث محدث محدث محدث محدث محدث محدث
+
+352
+00:34:03,120 --> 00:34:07,020
+محدث محدث محدث محدث محدث محدث محدث محدث محدث محدث
+
+353
+00:34:07,020 --> 00:34:07,160
+محدث محدث محدث محدث محدث محدث محدث محدث محدث محدث
+
+354
+00:34:07,160 --> 00:34:08,340
+محدث محدث محدث محدث محدث محدث محدث محدث محدث محدث
+
+355
+00:34:08,340 --> 00:34:23,020
+محدث محدث محدث محدث محدث
+
+356
+00:34:23,020 --> 00:34:29,530
+مبعد إدخال الـ Vector إلى مجموعات بكتيريا
+
+357
+00:34:29,530 --> 00:34:34,130
+المناسبة، يتغير البكتيريا الهياركولترية إلى مجموعة
+
+358
+00:34:34,130 --> 00:34:39,470
+بيو-رياكترية لإنشاء كميات كبيرة من البروتين اللي
+
+359
+00:34:39,470 --> 00:34:43,390
+تحتوي على المنطقة التي تتعامل مع مجموعة DNA محددة،
+
+360
+00:34:43,390 --> 00:34:48,070
+هذه البروتين هي أكتر مستحيلًا مستخدمة لأي نوع من
+
+361
+00:34:48,070 --> 00:34:50,110
+الهرمونات التالية،
+
+362
+00:34:55,350 --> 00:35:03,230
+بروجسترون؟ والله ما أفهم هذا يعني العيب
+
+363
+00:35:03,230 --> 00:35:10,630
+في السؤال هذا بالنقطة الأولى أنه
+
+364
+00:35:10,630 --> 00:35:16,830
+إذا ما عندك معلومات ثانية الكلام اللي حطه بخربطك
+
+365
+00:35:16,830 --> 00:35:22,880
+ومش مفيد كثير كثير بالنسبة بعض الأحيان يعنيهذه
+
+366
+00:35:22,880 --> 00:35:30,260
+تحتاج إلى معلومة تكون عارفها الآن بسأل، بسأل مثل
+
+367
+00:35:30,260 --> 00:35:37,520
+كريم أو اللي بدك يعني الإنسولين اللي نستخدمه، شو
+
+368
+00:35:37,520 --> 00:35:42,060
+هو؟ من وين بتجيبه؟ شايف الإنسولين الإبرة اللي
+
+369
+00:35:42,060 --> 00:35:45,880
+بنعطي المرضى السكري؟ سواء type 1 أو type 2،
+
+370
+00:35:45,880 --> 00:35:49,260
+بنعطيهم إنسولين، من وين بنجيبه؟
+
+371
+00:35:56,590 --> 00:36:02,290
+أي طالب بيحب يشارك؟
+
+372
+00:36:02,290 --> 00:36:09,690
+نعم أهلا
+
+373
+00:36:09,690 --> 00:36:14,210
+وسهلا الله يرضى عليك يا كريم أنت أو أي طالب ثاني
+
+374
+00:36:14,210 --> 00:36:19,550
+الإنسولين اللي بنستخدمه في علاج الآن مرضى السكري
+
+375
+00:36:19,550 --> 00:36:23,930
+بنقول عنه human insulin من وين بنجيبه؟
+
+376
+00:36:27,400 --> 00:36:33,840
+وصلّه في المختبرات آه، كيف؟
+
+377
+00:36:33,840 --> 00:36:37,480
+أعتقد أول ما استخلصوه، استخلصوه من القرن وبعدين
+
+378
+00:36:37,480 --> 00:36:43,180
+صاروا ياخدوا الجينات من الإنسان وصاروا البروتينات
+
+379
+00:36:43,180 --> 00:36:48,860
+في المختبر صحيح، لأ، مش بالمختبر، مختبر، يعني هيك
+
+380
+00:36:48,860 --> 00:36:52,240
+فالنسبة
+
+381
+00:36:52,240 --> 00:36:53,420
+لهذا الموضوع
+
+382
+00:36:56,560 --> 00:37:04,260
+بالنسبة للـ «إنسولين»
+
+383
+00:37:04,260 --> 00:37:10,660
+زمان أول شيء كانوا يعزلوا الهرمون اللي هو البروتين
+
+384
+00:37:10,660 --> 00:37:18,640
+يعزلوا من البقر ومن البقرة الكبيرة فيقدروا يفلتروا
+
+385
+00:37:18,640 --> 00:37:22,640
+دمها ويعزلوا شوية البروتين اللي هو الـ «إنسولين»
+
+386
+00:37:22,640 --> 00:37:28,270
+تبع البقروبعدين يحقق الإنسان فيه فهيك يعني أصلا
+
+387
+00:37:28,270 --> 00:37:35,610
+هذا البروتين مش متطابق كتير مع المستقبل للإنسولين
+
+388
+00:37:35,610 --> 00:37:41,150
+اللي عند الإنسان ففيه مشكلة زائد أنه يعني تركيبته
+
+389
+00:37:41,150 --> 00:37:45,970
+شويه مختلفة عن الإنسولين البشري وبالتالي فيه مشكلة
+
+390
+00:37:45,970 --> 00:37:50,650
+فبالتالي ماكنش نافع كتير بس المرضى كان يموتوا
+
+391
+00:37:50,650 --> 00:37:56,520
+ومضطرين نعطيهم يام تمام؟فهسا لما تقول أنت يا كريم
+
+392
+00:37:56,520 --> 00:38:02,480
+كيف صنعوه في المختبر الـ stem السؤال بيشرح كيف
+
+393
+00:38:02,480 --> 00:38:07,360
+صنعوه الأصل
+
+394
+00:38:07,360 --> 00:38:13,080
+لما أنت أنت بتكون مهتم بهذا الشيء هدفك أول شيء
+
+395
+00:38:13,080 --> 00:38:19,460
+تأذل الـ gene تبعه ماشي بدك تأذل الـ DNA اللي
+
+396
+00:38:19,460 --> 00:38:26,330
+بيحتوي الـ Insulin تبعهالـ الـ الاشي اللي أنت بدك
+
+397
+00:38:26,330 --> 00:38:32,170
+إيه فيه مشكلة بالنسبة للمن تقول أنا بدي أخد الـ
+
+398
+00:38:32,170 --> 00:38:36,790
+«جين» أو الـ «DNA» مباشرة من الإنسان أنه فيه إشي
+
+399
+00:38:36,790 --> 00:38:40,470
+اسمه «Intron وإكسون» يعني لما تاخد أنت الـ «DNA»
+
+400
+00:38:40,470 --> 00:38:46,470
+كله ما بتقدر تاخد يعني القطعة اللي لازم بس هي اللي
+
+401
+00:38:46,470 --> 00:38:49,950
+تصيرها الـ Transcription و Translation بحيث تصير
+
+402
+00:38:49,950 --> 00:38:56,200
+Amino Acidبدك تأخذ كل الـ DNA فالأسهل مرات إنك إذا
+
+403
+00:38:56,200 --> 00:39:01,900
+بتدور على الإشي الـ Messenger RNA تبعه ماشي فإذا
+
+404
+00:39:01,900 --> 00:39:08,320
+أنت مهتم بإشي بروح بجيب خلية و بدور على بعزل الـ
+
+405
+00:39:08,320 --> 00:39:13,060
+Messenger RNA تبع الإشي لإنه يكون الخلية جاهزة
+
+406
+00:39:13,060 --> 00:39:17,210
+بالشكل اللي أنا بديهااللي هو اللي حقيقةً كامل
+
+407
+00:39:17,210 --> 00:39:22,310
+وبيدياه كـ Amino Acid واشي تحطيهن الـ Protein
+
+408
+00:39:22,310 --> 00:39:29,330
+مابدي الـ Exons و الـ Introns الجزء الإضافي فهو
+
+409
+00:39:29,330 --> 00:39:36,150
+أنا بقولك أنا روحت وعزلت الـ RNA الـ RNA بالألات
+
+410
+00:39:36,150 --> 00:39:41,370
+في المختبر بقدر بالـ PCRبالـ Polymerase Chain
+
+411
+00:39:41,370 --> 00:39:48,270
+Reaction أول شي جبت، شو اسمه؟ جبت الـ RNA بـ
+
+412
+00:39:48,270 --> 00:39:51,770
+Reverse Transcriptase اللي هو الـ Enzyme اللي
+
+413
+00:39:51,770 --> 00:39:58,690
+وظيفته طلّق للـ DNA للـ RNA هذا كونت RNA DNA
+
+414
+00:39:58,690 --> 00:40:04,030
+Double Strand حطيت قدامها Promoter وحطيت
+
+415
+00:40:04,030 --> 00:40:10,230
+Terminator بالأخير وهذولا حطيتهم بـ P-VectorVector
+
+416
+00:40:10,230 --> 00:40:19,730
+يعني فيروس بيحكم حاله في البكتيريا كل الشغل هذا
+
+417
+00:40:19,730 --> 00:40:24,770
+لأنه الشغل على الـ Cell Culture صعب بكتيريا الـ
+
+418
+00:40:24,770 --> 00:40:29,950
+Culture في المختبر أسهل بكتير فأنا لما كيف أصلا
+
+419
+00:40:29,950 --> 00:40:33,810
+بنصنع الإنسولين وهذا بداية سؤالي أنه في الغالب
+
+420
+00:40:34,610 --> 00:40:38,610
+جابوا الـ RNA تبع الإنسلين ورجعوا له الـ DNA
+
+421
+00:40:38,610 --> 00:40:42,490
+الكامل اللي بدنا إياه مش زي ما في جسم الإنسان
+
+422
+00:40:42,490 --> 00:40:48,650
+أحيانًا فيه Introns وExons و بعدين حولناها لـ DNA
+
+423
+00:40:48,650 --> 00:40:54,690
+و الـ DNA حطيت إشي يجبر البكتيريا تعرف وين تبدأ و
+
+424
+00:40:54,690 --> 00:40:59,140
+وين توقف الـ Promoter عشان تبدأوالـ Terminator
+
+425
+00:40:59,140 --> 00:41:04,640
+عشان يتوقف عشان أكون سخلي أو أشتغلي على القطعة هذه
+
+426
+00:41:04,640 --> 00:41:09,320
+بحطها في الـ Vector اللي هو الـ Virus الـ Plasmid
+
+427
+00:41:09,320 --> 00:41:14,940
+عشان ينحقن جوا بكتيريا وجوا البكتيريا بتطير هذه
+
+428
+00:41:14,940 --> 00:41:24,710
+الشغلتتم، شو بيسموها، يعني بتتم الـ Translation،
+
+429
+00:41:24,710 --> 00:41:27,590
+الـ Transcription و Translation فبتعطيني الـ
+
+430
+00:41:27,590 --> 00:41:33,210
+Protein اللي بدّيها فهذا كله الجزء الأول بيشرح هذه
+
+431
+00:41:33,210 --> 00:41:38,830
+القاعدة أو بيشرح هذه النقطة بالنسبة
+
+432
+00:41:38,830 --> 00:41:41,910
+للسؤال
+
+433
+00:41:41,910 --> 00:41:43,850
+هنا يعني
+
+434
+00:41:45,510 --> 00:41:50,330
+هذه اللي عملوها عشان ينتجوا هذا الأمر لأنه هرمون
+
+435
+00:41:50,330 --> 00:41:53,450
+والله ما بعرف يعني أنا اللي بعرفه اللي هو
+
+436
+00:41:53,450 --> 00:41:58,830
+الإنسولين بدرجة أساسية بس بيعملوه لبروتين تبع
+
+437
+00:41:58,830 --> 00:42:01,190
+الإنسولين اللي احنا بدناه عشان هيك بيسموها
+
+438
+00:42:01,190 --> 00:42:04,790
+«Recomponent DNA Technology» «Recomponent» يعني
+
+439
+00:42:04,790 --> 00:42:08,730
+أنت بتحط تبع الفيروس على تبع البكتيريا على تبع
+
+440
+00:42:08,730 --> 00:42:16,090
+الإنسان على تبع كذا، بتحط DNA مختلفةبس بيظل هي نفس
+
+441
+00:42:16,090 --> 00:42:20,590
+المبادئ DNA لـ RNA لـ Polypeptide chain يعني بدك
+
+442
+00:42:20,590 --> 00:42:26,370
+تكون تمشي بالثلاث مقارنة فهي الآن البروجيسترون هو
+
+443
+00:42:26,370 --> 00:42:33,810
+اللي بيحطوله شكله يمكن باللي بيكونوا عندهم مثلا
+
+444
+00:42:33,810 --> 00:42:40,310
+الـ cancer أو الـ issue البروجيسترون أو الـ other
+
+445
+00:42:40,310 --> 00:42:50,580
+thingsكـ Blocker أو إشي فالـ
+
+446
+00:42:50,580 --> 00:42:53,660
+الشغل
+
+447
+00:42:53,660 --> 00:43:00,820
+اللي بدك تتكلم عنها ماشي اللي
+
+448
+00:43:00,820 --> 00:43:06,800
+هو موضوع إنه الـ الـ الـ protein hormones الـ
+
+449
+00:43:06,800 --> 00:43:10,780
+receptor اللي لهم على سطح الخلية الـ lipid hormone
+
+450
+00:43:11,270 --> 00:43:15,990
+اللي هم الـ Steroids، فيه Glucocorticoids،
+
+451
+00:43:15,990 --> 00:43:19,530
+Mineralocorticoids، Sex Hormones، الأشياء اللي زي
+
+452
+00:43:19,530 --> 00:43:24,590
+هيكي الـ Receptor تبعهم Intracytoplasmic فهنا يعني
+
+453
+00:43:24,590 --> 00:43:28,690
+أنا أظن السؤال، الـ trick اللي فيهإن هدولة كلهم
+
+454
+00:43:28,690 --> 00:43:32,810
+بالأخير بروتينات الـ glucagon والإنسلين
+
+455
+00:43:32,810 --> 00:43:38,170
+والإنسلينات والبروتيرويد والبروجسترول والوحيد الـ
+
+456
+00:43:38,170 --> 00:43:42,130
+intraceptive platelet مني فاهم أنا يعني أكيد
+
+457
+00:43:42,130 --> 00:43:50,060
+جابتهم صحيحة ماشيبس هنا بقولك DNA-binding proteins
+
+458
+00:43:50,060 --> 00:43:53,880
+include transcription factors، Steroids receptors
+
+459
+00:43:53,880 --> 00:43:56,820
+and thyroid hormone receptors, fat-soluble
+
+460
+00:43:56,820 --> 00:44:00,360
+receptors, vitamin D، DNA transcription or
+
+461
+00:44:00,360 --> 00:44:10,960
+replication proteins، ماشي، سؤال صعب ويعني بتكلم
+
+462
+00:44:10,960 --> 00:44:14,340
+عن مواضيع عميقة كتير ويعني
+
+463
+00:44:15,680 --> 00:44:20,920
+بدو الواحد على الأقل يعني أنا لو طلعت على السؤال
+
+464
+00:44:20,920 --> 00:44:25,540
+ما كنت راح عارف أتجاوبه كنت راح أقول يمكن الـhigh
+
+465
+00:44:25,540 --> 00:44:30,520
+البروجيسترون على أساس هو من نوعية مختلفة يعني استم
+
+466
+00:44:30,520 --> 00:44:34,440
+السؤال الواضح في أشياء كتير وبعدين بيجي بالأخير
+
+467
+00:44:34,440 --> 00:44:38,720
+يقولك أن هذا receptor لهرمون أنوه هرمون هذا والله
+
+468
+00:44:38,720 --> 00:44:40,860
+ما بعرفها ماكنت عارفها من قبل
+
+469
+00:44:45,120 --> 00:44:54,080
+في سؤال من دكتورة نادية في السؤال السابق اللي كان
+
+470
+00:44:54,080 --> 00:44:59,840
+فيه عن الـ Weinberg equation يقول دكتور المفترض
+
+471
+00:44:59,840 --> 00:45:05,260
+احتمالية أنه يكون حامل للمرض هي 2Q ومش Q واحتمال
+
+472
+00:45:05,260 --> 00:45:10,510
+أنه ينقل الأليل المصاب في حالة لو كان حامل هي نصمش
+
+473
+00:45:10,510 --> 00:45:17,210
+عارف هي بتسأل ولا بتعلق؟ مش موجودة اللي بدونها
+
+474
+00:45:17,210 --> 00:45:23,410
+طلعت أو شي زي هي ناشي دكتور أحمد بدك تبلغك التالي
+
+475
+00:45:23,410 --> 00:45:30,490
+في فرق بين نظري ناشي و بين إنسان أنا عندي معلومة
+
+476
+00:45:30,490 --> 00:45:42,890
+عنه أسا أنا عندي شخصين حاملين careerماشي يعني ال
+
+477
+00:45:42,890 --> 00:45:47,830
+.. لما ال .. السؤال اللي بتحكي عنه عن المعادلة
+
+478
+00:45:47,830 --> 00:45:52,170
+دكتور أحمد معايا الله يطبع عليه صحيح يا دكتور
+
+479
+00:45:52,170 --> 00:45:59,450
+اتنين عندهم طفل مصاب إذن الأب والأم شوا لـ X
+
+480
+00:45:59,450 --> 00:46:02,350
+-linked recesses أو Autosomal recesses خليني أقول
+
+481
+00:46:02,350 --> 00:46:04,110
+Autosomal recesses ماشي
+
+482
+00:46:08,330 --> 00:46:16,830
+لما نكون على حسب المعادلة إثنين عندهم career صح؟
+
+483
+00:46:16,830 --> 00:46:20,650
+تمام؟
+
+484
+00:46:20,650 --> 00:46:26,090
+تمام إن شاء الله إذا في طفل مصاب معناته أكيد الأب
+
+485
+00:46:26,090 --> 00:46:34,310
+و الأم career صح؟ صحيح أفرضجابوا بدهم يجيبوا بدهم
+
+486
+00:46:34,310 --> 00:46:43,110
+يخلفوا عندهم طفل شو اسمه؟ عندهم طفل يعني حامل
+
+487
+00:46:43,110 --> 00:46:50,370
+مرافيه وبدنا نسأل شو نسبت إنه يطلع career إنه يطلع
+
+488
+00:46:50,370 --> 00:46:57,870
+career ماشي نص إنه يطلع إنسان مصاب ربع إنه يطلع
+
+489
+00:46:57,870 --> 00:47:03,070
+completely healthy ربعهذولا النسب لشخص أنا ما بعرف
+
+490
+00:47:03,070 --> 00:47:08,490
+هو راح يطلع مصاب ولا مش مصاب فاهم عليك أيه؟ بس زي
+
+491
+00:47:08,490 --> 00:47:13,510
+النسب اللي أخدناها البنت
+
+492
+00:47:13,510 --> 00:47:22,630
+هذه ماشي اللي كانت تسأل لأنه هي حامل وأخوها مصاب
+
+493
+00:47:22,630 --> 00:47:31,890
+ماشي هي في احتمال أنها تكون مصابة؟ شو رأيك؟إذا كان
+
+494
+00:47:31,890 --> 00:47:35,450
+الوالد و الوالدة، واحد منهم هو اللي بيحمل
+
+495
+00:47:35,450 --> 00:47:59,090
+الـ………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………
+
+496
+00:48:00,500 --> 00:48:07,100
+البنت لمّا أنقجت وعمرها مثلًا عشرين سنة وصارت حامل
+
+497
+00:48:08,090 --> 00:48:16,010
+ما هي احتمالية أنها تكون رُبع برُبع بنُص، رُبع
+
+498
+00:48:16,010 --> 00:48:24,470
+إنها مُصابة، رُبع إنها مُصابة،
+
+499
+00:48:24,470 --> 00:48:27,850
+رُبع إنها مُصابة، رُبع إنها مُصابة، رُبع إنها
+
+500
+00:48:27,850 --> 00:48:37,830
+مُصابة، رُبع إنها مُصابة،
+
+501
+00:48:39,660 --> 00:48:46,440
+قلنا نص؟ لأ، سلسان بيصير كده؟ بيصير سلسان صحيح،
+
+502
+00:48:46,440 --> 00:48:49,640
+لأن أنت تلغي احتمال من الـ «حامل» لغاية الربع إنه
+
+503
+00:48:49,640 --> 00:48:53,980
+حامل اللي هو المصاب، هي أكيد مش مصابة، بس شو
+
+504
+00:48:53,980 --> 00:49:00,380
+احتمالية إنها حامل، بتكون يا إما سلسة، الثلاثة
+
+505
+00:49:00,380 --> 00:49:06,160
+أرباع اللي ضايلات، بخليهم واحد، سلسة بتكون إنها
+
+506
+00:49:06,160 --> 00:49:10,580
+completely normalوثلثين إحتمالية إنها تكون
+
+507
+00:49:10,580 --> 00:49:16,140
+«Carrier» «Carrier» مظبوط وهي أنا غيرت النسب لأنه
+
+508
+00:49:16,140 --> 00:49:20,460
+أنا عرفت إنها مش مصابة هو في سؤال مشابه للفكرة هذه
+
+509
+00:49:20,460 --> 00:49:22,780
+برضه موجود في التقرير اللي فات ما احنا اتناقشنا
+
+510
+00:49:22,780 --> 00:49:29,300
+على إشي زي هيك المحاضرة اللي فاتت في سؤال نفس
+
+511
+00:49:29,300 --> 00:49:33,900
+الفكرة أو نفس المنطق موجود في الكتاب نفسه كتاب
+
+512
+00:49:33,900 --> 00:49:40,290
+كابلان أه أه أهالنسبة كانت الجواب ثلثين صحيح لأن
+
+513
+00:49:40,290 --> 00:49:43,630
+في سؤال اللي كانت الثلث أجاني واحد سألني ليش أجت
+
+514
+00:49:43,630 --> 00:49:50,510
+الثلث الثلث لأنه أنا أتأكدت إنه هي هي مش مصابة
+
+515
+00:49:50,510 --> 00:49:55,090
+مظهريًا بما أنه مش مصابة إحتمالية الجزء اللي فيه
+
+516
+00:49:55,090 --> 00:50:00,680
+بتمثل إنها مصابة لو كان لسة الأم حاملماشي، و
+
+517
+00:50:00,680 --> 00:50:07,580
+بتسألني أنت شو احتمالية أنه البنت أو اللي راح يولد
+
+518
+00:50:07,580 --> 00:50:13,780
+ولد ولا بنت يطلع مثلا career بقولك نص، مصاحب ربع،
+
+519
+00:50:13,780 --> 00:50:18,500
+أنه يكون طبيعي completely normal ربع، ماشي، إذا
+
+520
+00:50:18,500 --> 00:50:22,940
+سألني شو احتمالية مظهريا يكون طبيعي بقولك ثلاثة
+
+521
+00:50:22,940 --> 00:50:30,590
+ارباع career و normalفإذا طلعت هي Normal-looking،
+
+522
+00:50:30,590 --> 00:50:33,550
+Phenotypical هي شو احتمالية إنها تكون Career
+
+523
+00:50:33,550 --> 00:50:39,790
+الثلثانة، هيك راح تكون فهي النقطة إنه يعني الواحد
+
+524
+00:50:39,790 --> 00:50:50,770
+يرسم الجداوي ومعين يعرف هل أنا بحكي يعني لما أنصح
+
+525
+00:50:50,770 --> 00:50:56,050
+أو أجاب السؤال عن إشي أنا متأكد منهيعني اللي هي
+
+526
+00:50:56,050 --> 00:51:01,690
+إنه، يعني بالذات الأباء والأمهات اللي راح يعطوا
+
+527
+00:51:01,690 --> 00:51:07,770
+مثلا، مثلا بقولك الطفل
+
+528
+00:51:07,770 --> 00:51:12,250
+اللي هو هذا طلع عنده إصابة شو الحمل اللي بعده
+
+529
+00:51:12,250 --> 00:51:16,090
+احتمالية إنه يطلع عنده إصابة؟ الـ Autism-recessive
+
+530
+00:51:16,090 --> 00:51:20,770
+بتكون ربع لأن أنا متأكد الأباء الأثنين Carriers
+
+531
+00:51:20,770 --> 00:51:27,200
+لأنه طلع ولد مصاب من قبلفإذا من قبل أنا متأكد
+
+532
+00:51:27,200 --> 00:51:31,080
+الأثنين career يعني زي مثل الـ Bomb Disease هذا
+
+533
+00:51:31,080 --> 00:51:37,680
+الحالة الطفل الأولاني اللي جابته المرأة هذه الأبو
+
+534
+00:51:37,680 --> 00:51:42,320
+أكيد career فهو واحد منها المتين اللي عندهم
+
+535
+00:51:42,320 --> 00:51:48,920
+الـGene هذا طلع بالصدفة، بالحظ السيء إنه كمان هو
+
+536
+00:51:48,920 --> 00:51:53,970
+حامل شايف علي؟ واحد منها المتينيعني احتمالية
+
+537
+00:51:53,970 --> 00:52:00,930
+قليلة، بس هذا نصيبهم، ماشي فالآن اللي لما يقول لك
+
+538
+00:52:00,930 --> 00:52:05,130
+«طب شو احتمالية ان الطفل اللي بعده يكون نفس
+
+539
+00:52:05,130 --> 00:52:11,030
+الاشي؟» بتقول «لأن الأم بدل ما هي النسبة واحد في
+
+540
+00:52:11,030 --> 00:52:14,970
+كل أربعين ألف في الشكل الطبيعي، بما أن أنا عرفت أن
+
+541
+00:52:14,970 --> 00:52:18,790
+الأم هي الـCarrier وكانت هي اللي حامل الـGene،
+
+542
+00:52:18,790 --> 00:52:23,750
+فإذا احتمالية أن هي تنقل نصمن هناك 1 على 200 بتصير
+
+543
+00:52:23,750 --> 00:52:30,330
+1 على 400، هيك بدأ أفكر، نعم كريم كان عندك تعليق
+
+544
+00:52:30,330 --> 00:52:34,870
+حابب تحكي كنت؟
+
+545
+00:52:34,870 --> 00:52:39,450
+لقيت بخصوص سؤال 20 اللي بيحكي عن دكتوره قبل شوية،
+
+546
+00:52:39,450 --> 00:52:43,810
+هو قرأت أنا تفسير السؤال منذ فترة، فالجواب الصح هو
+
+547
+00:52:43,810 --> 00:52:48,630
+بيطلع 1400، ولكن الرقم 1 على 200 هذا ما بيجي
+
+548
+00:52:48,630 --> 00:52:54,590
+مباشر، الـNoبنفرض إن
+
+549
+00:52:54,590 --> 00:53:00,430
+الـ«سبيرم دونار» تاني يكون «كارير» وبعد هيك بفرض
+
+550
+00:53:00,430 --> 00:53:05,270
+إن احتمال توريث القليل المصاب للإبن هو نص، فلذلك
+
+551
+00:53:05,270 --> 00:53:09,570
+بنقول، بنفرض انه كارير، فبتخدم قانون اتنان و بيه،
+
+552
+00:53:09,570 --> 00:53:15,870
+يعني بنقول اتنان اي واحد على ميتين ضرب مية و تسعة
+
+553
+00:53:15,870 --> 00:53:22,500
+كريم كريمسؤالك بالشكل هذا بخطر على بالي أو كنت
+
+554
+00:53:22,500 --> 00:53:31,300
+فاكر فيه بس خلّي الأمور سهلة ماشي ال wording لما
+
+555
+00:53:31,300 --> 00:53:39,920
+نحكي على النسب ماشي الواحد على الميتين من النسخة
+
+556
+00:53:39,920 --> 00:53:45,060
+كام يعني بدك تاخدها بهذا الشكليعني صح، يعني لا،
+
+557
+00:53:45,060 --> 00:53:49,020
+لا، لا تدخل الموضوعين شويه تربطهم أتبعاد، تتفكر
+
+558
+00:53:49,020 --> 00:53:58,600
+كتير، ماشي؟ ال .. ال .. لما نقول يعني هي طريقة
+
+559
+00:53:58,600 --> 00:54:04,620
+حسبتها وطريقة التعامل معاها، ماشي؟ ال .. يعني إذا
+
+560
+00:54:04,620 --> 00:54:09,060
+حطوا واحد على 800، بد الواحد هيك يكون متفكر كتير،
+
+561
+00:54:09,060 --> 00:54:15,200
+كتير، كتير وخربط حاله، ماشي؟لما احنا نحكي الآن على
+
+562
+00:54:15,200 --> 00:54:23,060
+ال… لما مثلا تقول ال…
+
+563
+00:54:23,060 --> 00:54:32,160
+مثلا تقول مثلا اللي عندهم O blood group نقول تسعة
+
+564
+00:54:32,160 --> 00:54:39,700
+بالنسبة ليه؟ ماشي؟ ماشي الحال يا كريم؟أه دكتور
+
+565
+00:54:39,700 --> 00:54:47,340
+صحيح هاي الـQ تربية، صح؟ لأن هذا Recessive صحيح،
+
+566
+00:54:47,340 --> 00:54:58,240
+إذا شو إحتمالية إنه الـGen يكون موجود؟ شو الـQ؟
+
+567
+00:54:58,240 --> 00:55:03,260
+الـ900 نعم،
+
+568
+00:55:03,260 --> 00:55:08,860
+فهيكون الـGen 39%رح يكون ثلاث من عشرة، يعني رح
+
+569
+00:55:08,860 --> 00:55:14,780
+يكون point three، صح؟ صحيح، هاي الـ point three
+
+570
+00:55:14,780 --> 00:55:21,320
+على نسخة هون أو نسخة هناك أو النسختين مع بعض، فاهم
+
+571
+00:55:21,320 --> 00:55:27,320
+عليك كيف؟ يعني ثلاثين بالمية من الإجمالي الـ two
+
+572
+00:55:27,320 --> 00:55:32,780
+copies الممكنات في كل واحد، هي نسبتها واحد على
+
+573
+00:55:32,780 --> 00:55:38,860
+ثلاثة، هيك بدك توقفهاما بأخد إنه هذه نسبة لـ copy
+
+574
+00:55:38,860 --> 00:55:43,900
+واحدة ولا two copies ولا كده، هو هنا بيقولك إن الـ
+
+575
+00:55:43,900 --> 00:55:49,400
+Q هي نسبة إنك أنت بتيجي بتاخدالجينات تبعت هذا
+
+576
+00:55:49,400 --> 00:55:56,360
+المكان لكل الـ «population» وبتشوف قداش نسبة هذا
+
+577
+00:55:56,360 --> 00:56:00,060
+الـ «gene» طبعاً على الـ «two copies» بدي تكون
+
+578
+00:56:00,060 --> 00:56:05,800
+وإنت ما فرقت إنه one copy هاي ولا هاي ولا اثنتين
+
+579
+00:56:05,800 --> 00:56:09,940
+مع بعض فاهم عليك إيه؟ إنه إذا إنت مثلا عندك هنا
+
+580
+00:56:09,940 --> 00:56:13,160
+two copies ممكن تقول هاي ال copy الأولى وهاي ال
+
+581
+00:56:13,160 --> 00:56:18,950
+copy الثاني للـ «gene» الموقع هذافأنا هنا ما بشتغل
+
+582
+00:56:18,950 --> 00:56:23,230
+على ذاك المبدأ يعني فانت خدها ببساطة إنه لما
+
+583
+00:56:23,230 --> 00:56:28,170
+نحطولك السؤال هيك إنه أنا ما بعرف هي الـCopy
+
+584
+00:56:28,170 --> 00:56:31,670
+الأولى ولا الثاني ولا الـHomozygous إنه الثنتين
+
+585
+00:56:31,670 --> 00:56:36,250
+هيك، بس نسبة الـGene هذا هيك ببساطة في ال
+
+586
+00:56:36,250 --> 00:56:41,430
+population واحد في المتان، وهذه المرة يعني للأبو
+
+587
+00:56:41,900 --> 00:56:48,660
+للجهة هذه، نسبة توريث الأليل المصاب هو 1 على 200،
+
+588
+00:56:48,660 --> 00:56:55,300
+هيك القطة ماشي، والأم career أكيد فبالتالي، نسبة
+
+589
+00:56:55,300 --> 00:56:59,660
+أعطاها للـ Chrome للأليل هذا، 1 على 2 فبتطلع
+
+590
+00:56:59,660 --> 00:57:05,220
+النتيجة 1 على 400 ما أنا بقولت إنه أنا بتكلم على
+
+591
+00:57:05,220 --> 00:57:10,040
+نموذج إنه واحد من الـ Two copies هو الـ 1 على 200
+
+592
+00:57:10,740 --> 00:57:14,940
+لأ، ما حكيت هيك، حكيت كلها فاهم عليك كيف؟ فهذه
+
+593
+00:57:14,940 --> 00:57:19,200
+الواحد ينتبع عليها، بتخربط شوية، أه، في أسئلة
+
+594
+00:57:19,200 --> 00:57:24,080
+أخرى؟ دكتور، أظن السؤال اللي بتدور عليه هو السؤال
+
+595
+00:57:24,080 --> 00:57:30,020
+11 أه، شو السؤال 11؟ هو الأجزة الأول ولا الثاني؟
+
+596
+00:57:30,020 --> 00:57:33,960
+الأول، الأول طيب،
+
+597
+00:57:33,960 --> 00:57:41,310
+طيب، أيوة، هذا هو، ماشي؟إذا حاولنا نقرأ الـ STEM،
+
+598
+00:57:41,310 --> 00:57:44,930
+خلّيني نرجع للقبل كـ Pharmaceutical researcher
+
+599
+00:57:44,930 --> 00:57:49,330
+develops a new drug that affects bacterial protein
+
+600
+00:57:49,330 --> 00:57:55,350
+synthesis in an experiment الـ E coli was exposed
+
+601
+00:57:55,350 --> 00:57:59,330
+to that drug and serially cultured in media tagged
+
+602
+00:57:59,330 --> 00:58:03,840
+nucleotides and amino acidsيعني كل هذا الكلام يعني
+
+603
+00:58:03,840 --> 00:58:08,000
+بيشرحلك ال .. شو اسمه؟ ال .. الاشي ال .. ال ..
+
+604
+00:58:08,000 --> 00:58:12,120
+يعني السيناريو زي اللي اتكلمنا قبل شوية عن الـ
+
+605
+00:58:12,120 --> 00:58:15,000
+Recombinant DNA Technology بيشرحلك كيف انهم
+
+606
+00:58:15,000 --> 00:58:18,340
+بيعملوها للأيام هذه It is found that the drug
+
+607
+00:58:18,340 --> 00:58:22,920
+inhibits molecules that recognize the heightened
+
+608
+00:58:22,920 --> 00:58:27,220
+codon in the bacterial messenger RNA fragment
+
+609
+00:58:27,220 --> 00:58:30,700
+shown in the image below ماشي، which of the
+
+610
+00:58:30,700 --> 00:58:39,770
+following molecules isبالتأكيد، الهدف هو الـ
+
+611
+00:58:39,770 --> 00:59:00,650
+UUA اللي هو جسمهم أنا آسف، طلع السؤال ماشي،
+
+612
+00:59:00,650 --> 00:59:02,150
+الـ
+
+613
+00:59:07,510 --> 00:59:14,410
+بالنسبة لـ Heightened Codon in the bacterial RNA
+
+614
+00:59:14,410 --> 00:59:20,710
+fragment shown in the image below فالشيء
+
+615
+00:59:20,710 --> 00:59:24,250
+اللي هو هنا بيحاول، إحنا عكس اللي حكيناه من قبل
+
+616
+00:59:24,250 --> 00:59:32,340
+قبل شوية مثال إنه أناعندي بروتين أجى فيه الـ Stop
+
+617
+00:59:32,340 --> 00:59:39,680
+codon بشكل نتيجة الـ mutation وبيطلع عندي البروتين
+
+618
+00:59:39,680 --> 00:59:47,520
+أقل، ماشي أو البروتين طلع، شو اسمه، مش موجود، يعني
+
+619
+00:59:47,520 --> 00:59:53,320
+البروتين أنا طيرته، طيرت جزء منه، وبالتالي طلع ليه
+
+620
+00:59:53,320 --> 00:59:56,040
+قصير، فالآن
+
+621
+01:00:00,700 --> 01:00:09,380
+بالنسبة له حاطة وانا الـ UAA أو ال .. ال .. ال ..
+
+622
+01:00:09,380 --> 01:00:19,500
+ال .. شو اسمه؟ ليش هيك بيصير؟
+
+623
+01:00:19,500 --> 01:00:25,780
+ال
+
+624
+01:00:25,780 --> 01:00:32,390
+..مثلًا، أي واحد من الموليكيول المتواجد في هذه
+
+625
+01:00:32,390 --> 01:00:38,530
+الدروك؟ اللي هو الـCharged RNA، أو الـTransferable
+
+626
+01:00:38,530 --> 01:00:43,830
+RNA، ما لهاش معنى، يعني هون اللي بيقولوا، هاي
+
+627
+01:00:43,830 --> 01:00:47,770
+الـSegment بهذا الشكل، وين ما هي موجودة، ويكون
+
+628
+01:00:47,770 --> 01:00:54,010
+عندي إشي غير هذا، بتحطه، بتصير هذا موجود، ماشي،
+
+629
+01:00:54,360 --> 01:01:02,680
+فالفكرة أني أنا، شو اسمه؟ يعني خلّيت stop codon
+
+630
+01:01:02,680 --> 01:01:08,900
+تيجي، ماشي؟ فالـ which of the following molecules
+
+631
+01:01:08,900 --> 01:01:15,680
+is the most likely target of this drug؟ الشو
+
+632
+01:01:15,680 --> 01:01:22,470
+اسمه؟ يعني هو أنا اللي بحكيلكم إياه، إنهبما إنه
+
+633
+01:01:22,470 --> 01:01:28,110
+أنا عندي 64 كودون الـ Triplets هدولة الاحتمالات 64
+
+634
+01:01:28,110 --> 01:01:34,170
+إنه 4×4×4 وعندي 20 Amino Acids كل Amino Acid اللي
+
+635
+01:01:34,170 --> 01:01:41,270
+أكثر، اللي له أكثر من كودون فالـ GUU والـ GUC والـ
+
+636
+01:01:41,270 --> 01:01:48,510
+GUA والـ GUG كلهم بيعملوا الـ Valine هدولة يعني لو
+
+637
+01:01:48,510 --> 01:01:52,400
+صار بينهمالـ Single Nucleotide بوليموفيزم ما راح
+
+638
+01:01:52,400 --> 01:01:56,940
+يتأثر البروتين على مستوى الـ DNA اختلف، صحيح، بس
+
+639
+01:01:56,940 --> 01:02:02,200
+مستوى البروتين ما راح يختلف يعني ما إله هالـ SNP
+
+640
+01:02:02,200 --> 01:02:07,740
+وظيفة أو تأثير فيه إيش اسمه Termination of Protein
+
+641
+01:02:07,740 --> 01:02:11,900
+Synthesis اللي هم الـ Stop Codons اللي هم UUAA
+
+642
+01:02:11,900 --> 01:02:22,540
+وUAG وUGA ماشي، الـ Stop Codon هذهماشي ما إلها
+
+643
+01:02:22,540 --> 01:02:27,380
+يعني راح يكون الـ amino acid راح يتدخله لما تصير
+
+644
+01:02:27,380 --> 01:02:33,640
+هذه الشغلة النتيجة بتصير إنه هذا بيخلي البروتين
+
+645
+01:02:33,640 --> 01:02:42,400
+يعني يطلع أو بيخلي البروتين ينفصل عن الـ ribosome
+
+646
+01:02:42,400 --> 01:02:47,640
+وينفصل عن الـ الـ machinery تبع صناعة البروتين
+
+647
+01:02:47,640 --> 01:02:52,530
+وبالتالي بيسموه releasing factorماشي، هي القطعة أو
+
+648
+01:02:52,530 --> 01:03:01,170
+النقطة اللي راح تكون لما يعني تنصاب بيظل يكمل أو
+
+649
+01:03:01,170 --> 01:03:05,470
+إذا أجت في نص إشي مطلوب راح تخليه يوقف هنا فكلها
+
+650
+01:03:05,470 --> 01:03:10,290
+يعني هنا يعتبرون الـReleasing Factor فالإجابات
+
+651
+01:03:10,290 --> 01:03:15,210
+اللي حاطينها الـChoice A Charge Transferile RNA
+
+652
+01:03:15,210 --> 01:03:18,950
+Delivers Amino Acids to the Protein Synthesis
+
+653
+01:03:18,950 --> 01:03:27,460
+Complexماشي اللي هم يعني charged هنا بمعنى أنه الـ
+
+654
+01:03:27,460 --> 01:03:31,880
+Transferral RNA عليه الـ amino acid اللي بده يشبك
+
+655
+01:03:31,880 --> 01:03:35,620
+على الـ polypeptide chain الـ elongation factors
+
+656
+01:03:35,620 --> 01:03:39,720
+اللي هم facilitate الـ Transferral RNA binding to
+
+657
+01:03:39,720 --> 01:03:43,040
+the transcription steps in protein synthesis يعني
+
+658
+01:03:43,040 --> 01:03:48,360
+اللي هم بضيفاً الـ Transcription proteins pre-RNA
+
+659
+01:03:49,190 --> 01:03:52,650
+مسنجر RNA، موليكيول تحتوي على كثير من الـ Introns
+
+660
+01:03:52,650 --> 01:03:56,750
+وكثير من الـ Extrons يعني
+
+661
+01:03:56,750 --> 01:04:07,030
+هذه اللي هم يعني الـ RNA أول ما يطلع من البروتين،
+
+662
+01:04:07,030 --> 01:04:13,390
+بيكون مشبوك فيه، بيكون الـ pre-messenger RNA الـ
+
+663
+01:04:13,390 --> 01:04:18,630
+initiation of gene transcriptionسيها سهيل إجابة
+
+664
+01:04:18,630 --> 01:04:22,710
+اللي هي releasing factor لأن هذا stop codon يعني
+
+665
+01:04:22,710 --> 01:04:30,890
+وظيفة الـ stop codon حتى يبطل يسوي translation حتى
+
+666
+01:04:30,890 --> 01:04:39,050
+يبطل يعمل translation وبالتالي يوقف بناء البروتين
+
+667
+01:04:39,050 --> 01:04:45,220
+عند هذه النقطة، ماشي؟فهدولة يعني أسئلة شو اسمه؟
+
+668
+01:04:45,220 --> 01:04:49,340
+يعني في نقطة المهم يعني أنا بتوقع إن الواحد يتذكر
+
+669
+01:04:49,340 --> 01:04:55,320
+إن الـUAA طبعاً هنا الـComplementary
+
+670
+01:04:55,320 --> 01:05:02,960
+لأنه الـStop Codon اللي هو الـUAA والـUAG وUGA
+
+671
+01:05:04,000 --> 01:05:08,700
+«أرستوبكودونز» هؤلاء الذكروهم يعني إذا بدي إشي
+
+672
+01:05:08,700 --> 01:05:13,600
+عشان تعرفه تجاوب وأسئلة إذا في سؤال بالأخير جابلك
+
+673
+01:05:13,600 --> 01:05:19,160
+إنه هاي أجاب واحد من هذولة الثلاثة اعرف إنه فيه
+
+674
+01:05:19,160 --> 01:05:24,760
+يعني توقيف أو توقيف يمكن يسبب مرض إنه في نص إشي
+
+675
+01:05:24,760 --> 01:05:31,210
+مطلوب أو يسبب مرض إنهالمفروض أن البروتين الطبيعي
+
+676
+01:05:31,210 --> 01:05:35,890
+يكون هالجدّة وتكون هنا stop codon مش موجودة فتطلع
+
+677
+01:05:35,890 --> 01:05:39,530
+البروتين أطول مش هو اللي أنا بديها، فبدأت تاخدها
+
+678
+01:05:39,530 --> 01:05:48,430
+هيك، ماشي؟ دكتور شوف سؤال 14، برنامج؟ طيب، احكي،
+
+679
+01:05:48,430 --> 01:05:56,470
+اقرأ النية قبل ما أوصله، طيب
+
+680
+01:06:00,210 --> 01:06:06,350
+«طفولة مولودة لأمرأة عمرها 34 عامة لديها صورة
+
+681
+01:06:06,350 --> 01:06:10,870
+رسمية بطيئة» ما
+
+682
+01:06:10,870 --> 01:06:19,410
+هو اسمه؟ يعني أيش الحالة اللي بتتكلم عنها؟
+
+683
+01:06:23,480 --> 01:06:27,760
+«ترايزومي 21» «ترايزومي 21»، صحيح، ماشي، ففيه Flat
+
+684
+01:06:27,760 --> 01:06:31,860
+Facial Profile Prominent Epicanthal Fold زي تبعات
+
+685
+01:06:31,860 --> 01:06:35,740
+العيون بتخليهم زي الصينيين A Holocystolic Murmur
+
+686
+01:06:35,740 --> 01:06:38,860
+Heard Loudest at the Left External Border، بيكون
+
+687
+01:06:38,860 --> 01:06:42,440
+Congelital Heart Disease VSD ولا كده وهذا بتتصير
+
+688
+01:06:42,440 --> 01:06:47,140
+الـKaryotype Analysis is consistent with Trisomy
+
+689
+01:06:47,140 --> 01:06:47,660
+21
+
+690
+01:06:50,160 --> 01:06:54,960
+ماشي، maternal and paternal karyotypes are normal
+
+691
+01:06:54,960 --> 01:06:59,620
+الـ karyotype analysis consisted with الـ Trisomy
+
+692
+01:06:59,620 --> 01:07:05,780
+21 عند مين يا دكتور معتزجي؟ عند ال maternal؟ لأ
+
+693
+01:07:08,700 --> 01:07:15,680
+هو عند الطفل المصاب عنده
+
+694
+01:07:15,680 --> 01:07:21,280
+نفسه هو إتلاقينا الـ Trisomy 21 السجينة فحصنا أمه
+
+695
+01:07:21,280 --> 01:07:26,720
+وأبوه طلعوا Normal طلعوا Normal، ماشي A restricted
+
+696
+01:07:26,720 --> 01:07:31,820
+fragment-length polymorphism analysis is conducted
+
+697
+01:07:31,820 --> 01:07:35,600
+to determine the parental origin of the extra
+
+698
+01:07:35,600 --> 01:07:41,610
+chromosomeيعني شو اللي عملوه هنا؟ هذه واحدة من الـ
+
+699
+01:07:41,610 --> 01:07:47,230
+Restriction Fragment Length Polymorphism الـ
+
+700
+01:07:47,230 --> 01:07:54,250
+Restriction Enzyme هو إنزايم ماشي بيقطع الـ DNA في
+
+701
+01:07:54,250 --> 01:08:01,190
+أماكن محددة يعني إله قطعة معينة إذا شافها وقوم هيك
+
+702
+01:08:01,190 --> 01:08:07,550
+بنصها بيقطع الـ DNA فبنتج عن الموضوع هذا إنهكيف
+
+703
+01:08:07,550 --> 01:08:13,050
+يعني بنستفيد من هذه الخاصية أنه أنا لما نقطع بهذا
+
+704
+01:08:13,050 --> 01:08:20,650
+المكان راح ينتج عندي مجموعة قطع أطوالها مختلفة بين
+
+705
+01:08:20,650 --> 01:08:29,470
+الناس فاهم عليك كيف؟ فالآن يعني كيف أعرف إنه قطع
+
+706
+01:08:29,470 --> 01:08:37,070
+أطوالها مختلفة؟ إنه باجي بعمل Electrophoresisماشي،
+
+707
+01:08:37,070 --> 01:08:40,410
+فلما أسول Electrophoresis مين اللي بيظل عند
+
+708
+01:08:40,410 --> 01:08:46,470
+الـOrigin أو بطيء، بيكون الإثقال الإكبار والصغار
+
+709
+01:08:46,470 --> 01:08:55,130
+الإخفاف بيطيروا لقدام كثير، واضح؟ تمام فالآن، اللي
+
+710
+01:08:55,130 --> 01:09:01,250
+عملوا هذه النوع من الدراسة اللي هي Restriction,
+
+711
+01:09:01,370 --> 01:09:05,480
+Fragment, Length, Polymorphismالتحقق في تحقيق الـ
+
+712
+01:09:05,480 --> 01:09:10,500
+Lithopoiebolism كان يتم تحقيقه لتحقق أصل الأطفال
+
+713
+01:09:10,500 --> 01:09:15,440
+لـ Extra Chromosome يعني أجوا وعملوا الدراسة هذه
+
+714
+01:09:15,440 --> 01:09:21,420
+لجنين المصاب على طفل المصاب والأب والأم عشان
+
+715
+01:09:21,420 --> 01:09:28,420
+يشوفوا من أين أخذ المرض هذا، تمام؟ماشي الحال؟
+
+716
+01:09:28,420 --> 01:09:32,340
+أمامك الله الـ DNA samples from the child mother
+
+717
+01:09:32,340 --> 01:09:36,460
+and father were obtained and the DNA is fragmented
+
+718
+01:09:36,460 --> 01:09:39,860
+with restriction enzyme the fragments are then
+
+719
+01:09:39,860 --> 01:09:44,500
+stored sorted يعني عملنا Electrophoresis by size
+
+720
+01:09:44,500 --> 01:09:48,860
+using southern blot technique ال southern blot هذا
+
+721
+01:09:48,860 --> 01:09:52,280
+نوعية بعد ما تعمل انت Electrophoresis ما بتقدر
+
+722
+01:09:52,280 --> 01:09:57,120
+تشوفهمفبتجيب بعد ما تعمل الـ Electrophoresis بتحط
+
+723
+01:09:57,120 --> 01:10:02,760
+عليها طبقة ثانية وبتسمحله يصير Blocking يعني طبق
+
+724
+01:10:02,760 --> 01:10:09,380
+وبتشوف أين أجى المكان تبعه فـ Labeling is done
+
+725
+01:10:09,380 --> 01:10:12,700
+using a probe that binds to a specific DNA
+
+726
+01:10:12,700 --> 01:10:16,700
+sequence close to the centromere of chromosome 21
+
+727
+01:10:16,700 --> 01:10:23,190
+The Repelif Analysisof the child mother is shown
+
+728
+01:10:23,190 --> 01:10:27,590
+below فهيكي شكله الـ mother هيكي ال father هيكي
+
+729
+01:10:27,590 --> 01:10:34,110
+وال child هيكي هذولة يعني مكان وين الـ centromere
+
+730
+01:10:34,110 --> 01:10:41,030
+تبع chromosome 21 موجود في كل واحد منهم ماشي ال
+
+731
+01:10:41,030 --> 01:10:45,930
+mother القناها الثنتين هذولة ال father القناها
+
+732
+01:10:45,930 --> 01:10:51,870
+بالثنتين هذولة ال child عنده هذولة الثلاثةماشي،
+
+733
+01:10:51,870 --> 01:10:55,730
+اذا شو اللي صار عند هذا الطفل؟ المشكلة عند أبوه
+
+734
+01:10:55,730 --> 01:11:02,850
+ولا أمه يا معتز؟ عنده Trisomy 21، يعني ماياخد two
+
+735
+01:11:02,850 --> 01:11:07,770
+copies من واحد وماياخد copy واحد من شخص تاني، من
+
+736
+01:11:07,770 --> 01:11:12,250
+من من، تتوقع من من المشكلة؟ من الأم أخد two copies
+
+737
+01:11:12,250 --> 01:11:16,750
+من الأم أخدتنتين، تفهم علي؟فهو من الأم ماخد ثنتين
+
+738
+01:11:16,750 --> 01:11:20,970
+ومن الأب ماخد واحدة الأب هاي واحدة بس فذولا ثنتين
+
+739
+01:11:20,970 --> 01:11:27,790
+تبعت الأم من بينات عنده فهو هنا المشكلة في الأم
+
+740
+01:11:27,790 --> 01:11:35,410
+ماشي الحال شو اسمه؟ سؤال Which of the following
+
+741
+01:11:35,410 --> 01:11:42,390
+meiosis events did this non-discussion most likely
+
+742
+01:11:42,390 --> 01:11:47,990
+occur؟طبعًا الـ maternal غلط استفنناهم استفنناهم
+
+743
+01:11:47,990 --> 01:11:53,190
+الـ maternal meiosis one or two قدرت حيرت فيها
+
+744
+01:11:53,190 --> 01:11:56,530
+عشانك أنا سألت السؤال يعني ما احنا جولنا إنه ممكن
+
+745
+01:11:56,530 --> 01:12:02,370
+تصير في واحد أو في اتنين لأ الواحد شو المطلوب
+
+746
+01:12:02,370 --> 01:12:11,450
+يصير؟ الواحد مش أنت يعني أنت تفهم الـ step الأولى
+
+747
+01:12:11,450 --> 01:12:18,250
+بالـ meiosisبكون عندي الـ «أنا بسوي بالأول S
+
+748
+01:12:18,250 --> 01:12:19,550
+-phase» «أنا بسوي بالأول S-phase» «أنا بسوي بالأول
+
+749
+01:12:19,550 --> 01:12:20,130
+S-phase» «أنا بسوي بالأول S-phase» «أنا بسوي
+
+750
+01:12:20,130 --> 01:12:22,550
+بالأول S-phase» «أنا بسوي بالأول S-phase» «أنا
+
+751
+01:12:22,550 --> 01:12:23,610
+بسوي بالأول S-phase» «أنا بسوي بالأول S-phase»
+
+752
+01:12:23,610 --> 01:12:23,810
+«أنا بسوي بالأول S-phase» «أنا بسوي بالأول S
+
+753
+01:12:23,810 --> 01:12:23,830
+-phase» «أنا بسوي بالأول S-phase» «أنا بسوي بالأول
+
+754
+01:12:23,830 --> 01:12:23,830
+S-phase» «أنا بسوي بالأول S-phase» «أنا بسوي
+
+755
+01:12:23,830 --> 01:12:27,170
+بالأول S-phase» «أنا بسوي بالأول S-phase» «أنا
+
+756
+01:12:27,170 --> 01:12:37,870
+بسوي بالأول S-phase» «أنا بسوي بالأول Sتنسم
+
+757
+01:12:37,870 --> 01:12:41,070
+الأثنين إلى واحد وواحد إلى واحد وواحد، فوين راح
+
+758
+01:12:41,070 --> 01:12:45,430
+تكون المشكلة؟ أنا بظن متين الـBiosis 2، شو كتب
+
+759
+01:12:45,430 --> 01:12:50,230
+الإجابة؟ وكتب واحد،
+
+760
+01:12:50,230 --> 01:12:58,050
+هاي فلأ، هحطها زي ما هم حكوا، أنا مش يعني، شو
+
+761
+01:12:58,050 --> 01:13:01,810
+اسمه؟ أتبروها، ليش طب مش أثنين؟
+
+762
+01:13:09,600 --> 01:13:21,080
+أه هنا الـ 2N ماشي الـ 2N اللي انفصلوا هم الـ
+
+763
+01:13:21,080 --> 01:13:26,500
+chromatids يعني نصي الكروموزوم بيصير انفصلوا،
+
+764
+01:13:26,500 --> 01:13:32,940
+ماشي؟ فزي ما هم حاطيه لكي هنا الأصل أنه الـ non
+
+765
+01:13:32,940 --> 01:13:38,130
+-disjunction in meiosis في الـ meiosis Iالأصل الـ
+
+766
+01:13:38,130 --> 01:13:43,870
+Normal إن يكون ينقسموا هيك وهيك ماشي، هذولة الـ
+
+767
+01:13:43,870 --> 01:13:49,090
+two copies from the same chromosome بنقسموا بحيث
+
+768
+01:13:49,090 --> 01:13:51,350
+يكون one chromosome هنا و one chromosome هنا
+
+769
+01:13:51,350 --> 01:13:56,560
+وبعدين بنفصل بهذا الشكلإذا كان الـ Non-Disjunction
+
+770
+01:13:56,560 --> 01:13:59,960
+ممكن يكون في الـ Meiosis I وممكن يكون في الـ
+
+771
+01:13:59,960 --> 01:14:05,560
+Meiosis II وهنا صار Non-Disjunction وهنا الـ Step
+
+772
+01:14:05,560 --> 01:14:07,060
+الأولى Non-Disjunction
+
+773
+01:14:10,560 --> 01:14:13,260
+الـNon-disjunction هي خسارة كروموزوم الممكن أن
+
+774
+01:14:13,260 --> 01:14:16,380
+تتفرق بشكل صحيح خلال تقسيم الجسم، هذا يمكن أن يكون
+
+775
+01:14:16,380 --> 01:14:20,720
+بسبب خسارة كروموزوم متعاملة لتفرق في ميوزوس 1 أو
+
+776
+01:14:20,720 --> 01:14:27,580
+خسارة أختي كروموتيد لتفرق في ميوزوس 2 أو ميتوسس،
+
+777
+01:14:27,580 --> 01:14:31,460
+في الـMonosomy، خسارة كروموزوم متعاملة في
+
+778
+01:14:31,460 --> 01:14:34,520
+الـTrisomy، خسارة كروموزوم متعاملة في الـGain،
+
+779
+01:14:34,520 --> 01:14:37,020
+الـMonosomy أو الـTrisomy بإمكانها أن تنتج من
+
+780
+01:14:37,020 --> 01:14:44,310
+مجموعة واحدة أو اثنين،طيب وبعدين non-disjunction
+
+781
+01:14:44,310 --> 01:14:47,510
+is a failure of chromosome pairs to separate this
+
+782
+01:14:47,510 --> 01:14:53,590
+could be failure of طب ما حكيناها shows that both
+
+783
+01:14:53,590 --> 01:14:57,230
+parents demonstrate two bands each parental band
+
+784
+01:14:57,230 --> 01:15:01,170
+represents a homologous chromosome 21 this child
+
+785
+01:15:01,170 --> 01:15:08,020
+has three bandsاللي فهمته يا دكتوره إنه في الـ
+
+786
+01:15:08,020 --> 01:15:12,340
+Meiosis 1 الكروموسومات بتنفصل على بعض أما في الـ
+
+787
+01:15:12,340 --> 01:15:16,560
+Meiosis 2 الكروماتيد هي اللي بتنفصل صحيح، صحيح هو
+
+788
+01:15:16,560 --> 01:15:21,580
+بيقول لك الـTrisomy 21 هو الكروموسوم ما نفصلش عشان
+
+789
+01:15:21,580 --> 01:15:25,340
+هيك في Meiosis 1؟ therefore the problem occurred
+
+790
+01:15:25,340 --> 01:15:29,120
+in the mother during Meiosis 1 when homolysis
+
+791
+01:15:29,120 --> 01:15:34,670
+chromosomes are separated صحيح، تمامماشي واضحة
+
+792
+01:15:34,670 --> 01:15:41,490
+الآن يا ماتز؟ تمام، سؤال 16 كمان عن الـ
+
+793
+01:15:41,490 --> 01:15:50,610
+Electrophoresis بعد أن هم مجلوبين طيب،
+
+794
+01:15:50,610 --> 01:15:54,310
+a 26-year-old woman comes to the office with her
+
+795
+01:15:54,310 --> 01:15:57,610
+husband for genetic counseling she's pregnant with
+
+796
+01:15:57,610 --> 01:16:01,650
+their second child whose gender is unknownمثلًا،
+
+797
+01:16:01,650 --> 01:16:05,550
+كلا الأطفال مميزين بشكل كام، وكانوا أولاً يولدوا
+
+798
+01:16:05,550 --> 01:16:09,090
+أولاً أبنة عمره ثلاث عامًا، وكان لديه حالات مستمرة
+
+799
+01:16:09,090 --> 01:16:14,310
+من الانيميا، الجوندس، وشعور مؤلم من يده وعينيه،
+
+800
+01:16:14,310 --> 01:16:16,250
+وكانت مجموعة دم من الفتى
+
+801
+01:16:16,250 --> 01:16:19,310
+والهيموجلوبينالكتروفوريسيس
+
+802
+01:16:19,310 --> 01:16:22,510
+تم تجاربها في مجال الـAlkaline pH، وهي الميزات
+
+803
+01:16:22,510 --> 01:16:24,770
+المظهرة هنا
+
+804
+01:16:36,520 --> 01:16:42,120
+هه؟ الـ Hemoglobin S يعني Sickle Cell Disease
+
+805
+01:16:42,120 --> 01:16:49,040
+الأنيميا والـ Jaundice ماشي ماعرفش ليش الـ
+
+806
+01:16:49,040 --> 01:16:55,420
+swellings of the hands and feet السبب فالـ بالنسبة
+
+807
+01:16:55,420 --> 01:17:00,000
+له في الحالة هذه بكون
+
+808
+01:17:00,000 --> 01:17:02,020
+شو اسمه؟
+
+809
+01:17:08,300 --> 01:17:12,880
+عملوا Hemoglobin Electrophoresis هنا فالـ
+
+810
+01:17:12,880 --> 01:17:19,860
+Hemoglobin A مش موجود هذا لمين؟ للطفل المصاب، صح؟
+
+811
+01:17:19,860 --> 01:17:24,080
+Blood sample is obtained from the boy and
+
+812
+01:17:24,080 --> 01:17:27,260
+Hemoglobin Electrophoresis is performed at
+
+813
+01:17:27,260 --> 01:17:33,800
+alkaline pH، ماشي الحال، فكل الـ Hemoglobin تبعه
+
+814
+01:17:34,820 --> 01:17:39,280
+ماشي، Hemoglobin S يعني مافيش Hemoglobin A ولا
+
+815
+01:17:39,280 --> 01:17:46,060
+Hemoglobin F اللي بيخفف وكله Hemoglobin S، تمام؟
+
+816
+01:17:46,060 --> 01:17:49,400
+فالآن السؤال What is the probability that the
+
+817
+01:17:49,400 --> 01:17:53,800
+unborn child will inherit one or more mutant
+
+818
+01:17:53,800 --> 01:17:57,940
+alleles from his parents؟ فشو هذا الـ Disease يا
+
+819
+01:17:57,940 --> 01:18:03,700
+معتز؟زي ما مدرسي يسأل؟ طيب، إذا أقرأ السؤال بشكل
+
+820
+01:18:03,700 --> 01:18:08,700
+دقيق، شو نسبت إن الـ Probability الـ unborn child
+
+821
+01:18:08,700 --> 01:18:13,200
+will inherit one or more؟ يعني المواحد يعني ما
+
+822
+01:18:13,200 --> 01:18:17,180
+إتنين، القليل اللي هم الـ mutant طيب، إذا شو
+
+823
+01:18:17,180 --> 01:18:24,240
+نسبهم؟ تلت أربعة تلت أربعة، هيك المفروض تلت
+
+824
+01:18:24,240 --> 01:18:31,020
+أربعة، ماشي؟السبب أنه فيه احتمال ربع هذا تظامن
+
+825
+01:18:31,020 --> 01:18:35,520
+recessive وإحنا نحكي على الطفل اللي مش مولود لسه
+
+826
+01:18:35,520 --> 01:18:42,280
+لو حكى one قليل mutant بيكون نص صح؟ لو one قليل
+
+827
+01:18:42,280 --> 01:18:48,700
+only أه كان لو حكى هيكي بس حكى one or more لو two
+
+828
+01:18:48,700 --> 01:18:54,140
+قليل برضه بيطلع ربع لو two قليل بيطلع ربع صحيحماشي
+
+829
+01:18:54,140 --> 01:18:57,880
+أنا مضطر هسأطلع أترككم لإنه عندي تدريس تاني يا
+
+830
+01:18:57,880 --> 01:19:01,980
+شباب، ماشي نلتقى يوم الإثنان الجاي إن شاء الله
+
+831
+01:19:01,980 --> 01:19:05,320
+يعطيك ألف عافية يا دكتور الله يحييكم، الله يحفظكم،
+
+832
+01:19:05,320 --> 01:19:08,540
+أهلين، أهلين، يالا السلام عليكم في رعاية الله
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/_M5_4TMqxTY_postprocess.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/_M5_4TMqxTY_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..a56308832ec353a7629d4dc42c9a2e3fb9c7b500
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/_M5_4TMqxTY_postprocess.srt
@@ -0,0 +1,2209 @@
+1
+00:00:00,000 --> 00:00:09,380
+الأن اليوم راح نتكلم عن الموضوع
+
+2
+00:00:09,380 --> 00:00:13,680
+الثالث من أنواع أو النوع الثالث Third type of
+
+3
+00:00:13,680 --> 00:00:19,400
+genetic diseases أو genetic inheritance اللي هو
+
+4
+00:00:19,400 --> 00:00:24,340
+الـComplex inheritance of common multifactorial
+
+5
+00:00:24,340 --> 00:00:29,100
+disorders القصد في الموضوع هذا أنه أحنا أصبحنا
+
+6
+00:00:29,100 --> 00:00:34,460
+أخدينالنوعين اللي هو الـ Chromosomal Diseases أو
+
+7
+00:00:34,460 --> 00:00:39,560
+Subchromosomal Diseases وهذه النوع النوع الثاني من
+
+8
+00:00:39,560 --> 00:00:43,280
+الـ Dalian أو الـ Single Genetic Disorders والآن
+
+9
+00:00:43,280 --> 00:00:46,240
+المجموعة الثالث اللي هي الأشياء بتكون
+
+10
+00:00:46,240 --> 00:00:49,920
+Multifactorial
+
+11
+00:00:49,920 --> 00:00:54,220
+الجدول
+
+12
+00:00:54,220 --> 00:01:03,380
+الأول يعنيبفرجنا أهمية أو نسبة الأمراض اللي فيها
+
+13
+00:01:03,380 --> 00:01:09,380
+جانب وراثي على ثلاث مراحل في حياة الإنسان أو في
+
+14
+00:01:09,380 --> 00:01:20,340
+حياة البشرلما نعمل دراسات على الحدوثة
+
+15
+00:01:20,340 --> 00:01:25,360
+فبالنسبة
+
+16
+00:01:25,360 --> 00:01:29,580
+للنوع الأول الـ Chromosomal Mutations أو
+
+17
+00:01:29,580 --> 00:01:34,120
+Chromosomal Diseases لما بنشوف الـ Incidence at
+
+18
+00:01:34,120 --> 00:01:41,830
+Birth لكل ألف ولادة نلاقيها تقريباً ستةوالـ
+
+19
+00:01:41,830 --> 00:01:47,470
+بالنسبة لـ الـ due to single gene mutation بقدر
+
+20
+00:01:47,470 --> 00:01:51,210
+بيكونوا حوالي عشرة و الـ multifactorial
+
+21
+00:01:51,210 --> 00:01:58,530
+inheritance بقدر حوالي خمسين فهذه يعني النسب
+
+22
+00:01:58,530 --> 00:02:02,790
+المتوقعة بس يعني الملاحظ بالكاميرا واحد يعني نقارن
+
+23
+00:02:02,790 --> 00:02:12,450
+بعدين اللي هي أنهعلى عمر الـ25 سنة الـ…
+
+24
+00:02:12,450 --> 00:02:16,650
+الـChromosomal mutations الـPrevalence يعني
+
+25
+00:02:16,650 --> 00:02:22,950
+بالنسبة لحدوثه أو تواجده بيتلاقيها صارت أقل، يعني
+
+26
+00:02:22,950 --> 00:02:26,990
+فيه احتمالية كبيرة أنه يكون الـChromosomal
+
+27
+00:02:26,990 --> 00:02:30,810
+mutation أن المريض ما أو الإنسان ما يطول لعمر
+
+28
+00:02:30,810 --> 00:02:37,380
+الـ25 سنةوالـ Single Gene Mutation برضه بنزله
+
+29
+00:02:37,380 --> 00:02:41,980
+وبالنسبة للـ Multifactorial Inheritance برضه
+
+30
+00:02:41,980 --> 00:02:46,740
+نسبتها عالية لما يكون الواحد يأخذ الـ Population
+
+31
+00:02:46,740 --> 00:02:54,700
+بشكل كامل الأرقام حتى بتختلف بشكل أكبر الـ Single
+
+32
+00:02:54,700 --> 00:03:00,100
+Mutation أو الـ Chromosomal Mutations عددها قليل
+
+33
+00:03:01,270 --> 00:03:06,070
+وكذلك الـ Single-Gene المندليان بيبينوا أكثر
+
+34
+00:03:06,070 --> 00:03:10,410
+بيصيروا عشرين تظهر أشياء أكتر على عمره أكبر شوية
+
+35
+00:03:10,410 --> 00:03:15,870
+وبعدين الـ Multifactorial بيصير إن انفجار فيهم
+
+36
+00:03:15,870 --> 00:03:21,170
+بتضاعف حوالي أتناشر مرة في الـ General Population
+
+37
+00:03:21,170 --> 00:03:26,090
+لحوالي 600 مرض With Multifactorial Inheritance
+
+38
+00:03:26,090 --> 00:03:32,960
+فصراحة أكبر مجموعة هي هذه المجموعةدورها بيبين أكثر
+
+39
+00:03:32,960 --> 00:03:43,660
+مع تقدم العمر أو زيادة العمر وهذه القضية بتفرضين
+
+40
+00:03:43,660 --> 00:03:49,200
+أهمية العوامل المشتركة بين البيئة وبين الوراثة
+
+41
+00:03:49,200 --> 00:03:56,930
+سنتين، كيف انهم بتدخلوا في قضيةفي قضايا تسبب
+
+42
+00:03:56,930 --> 00:04:02,450
+بالأمراض أكتر بكثير من single gene أو chromosomal
+
+43
+00:04:02,450 --> 00:04:10,910
+mutations الملاحظ على إن كثير من الظواهر الصحية
+
+44
+00:04:10,910 --> 00:04:15,710
+والطبية وغيرها في جسم الإنسان وفي حياة البشر بتكون
+
+45
+00:04:15,710 --> 00:04:19,470
+تتبع المنحنة الطبيعية اللي هو الـNormal
+
+46
+00:04:19,470 --> 00:04:23,630
+Distributionالـ Normal Distribution له أكثر من
+
+47
+00:04:23,630 --> 00:04:30,990
+طريقة يعني هيك بقولك زي شكل الجرس بيكون له شكل
+
+48
+00:04:30,990 --> 00:04:38,960
+معين الواحد بياخدها ضمن معايير معينةاللي هو يعني
+
+49
+00:04:38,960 --> 00:04:46,500
+أحيانًا يُذكر أنه الـ «distribution» أو التوزيع أو
+
+50
+00:04:46,500 --> 00:04:53,920
+الـ أو الـ يعني التوزيع الطبيعي اللي بيكون فيه الـ
+
+51
+00:04:53,920 --> 00:04:57,320
+«main» والـ «median» والـ «meridian» كلها نفس
+
+52
+00:04:57,320 --> 00:05:05,710
+القيمة يعني المتوسط الحسابيوأكثر قراءة تحدث
+
+53
+00:05:05,710 --> 00:05:09,850
+والقراءة
+
+54
+00:05:09,850 --> 00:05:14,870
+اللي بالنص تمامًا إذا رتبناهم كلها بتكون قيم
+
+55
+00:05:14,870 --> 00:05:20,690
+متساوية مثلًا زي هنا مثال على الـ Systolic Blood
+
+56
+00:05:20,690 --> 00:05:27,340
+Pressure اللي هو ضغط القلب، ضغط الدم الإنقباضيوأنا
+
+57
+00:05:27,340 --> 00:05:33,100
+بأخد
+
+58
+00:05:33,100 --> 00:05:37,340
+قراءات من عدد كبير من البشر وألاقيهم ماشيين بهذه
+
+59
+00:05:37,340 --> 00:05:44,200
+الطريقة الـ mean بالنصف الـ one standard deviation
+
+60
+00:05:44,200 --> 00:05:49,660
+يعني انحراف معياري واحد one standard deviation
+
+61
+00:05:49,660 --> 00:05:59,790
+بغطي تقريبًا 67% من ال populationيعني تقريبًا ثلثي
+
+62
+00:05:59,790 --> 00:06:05,910
+الفرقات بتكون ضمن حوالين الـMean بـOne Standard
+
+63
+00:06:05,910 --> 00:06:09,550
+Deviation لما نحط Two Standard Deviations بنوصل
+
+64
+00:06:09,550 --> 00:06:18,250
+حوالي 95% من الـCalculation يعني هذه قيم وأشياء
+
+65
+00:06:18,250 --> 00:06:23,390
+كثيرة من ظواهر الحياة الطبيعية بتلاقيها بتتبع هذا
+
+66
+00:06:23,390 --> 00:06:27,930
+المنحنةوبتكون ضمن هذا النظام وبتكون إنه إذا الواحد
+
+67
+00:06:27,930 --> 00:06:31,950
+بعرف الـMean والـStandard Deviation إن هذولا
+
+68
+00:06:31,950 --> 00:06:40,090
+الرقمين بتلاقي بيستطيع أنه يعني يتخيل أو يكوّم
+
+69
+00:06:40,090 --> 00:06:45,450
+فكرة أو يرسم صورة عن كيف القراءات راح تكون
+
+70
+00:06:45,450 --> 00:06:48,530
+فبالنسبة
+
+71
+00:06:48,530 --> 00:06:50,830
+للأمراض
+
+72
+00:06:53,330 --> 00:06:59,470
+اللي هي Multifactorial اللي بتنشأ بسبب تداخلات من
+
+73
+00:06:59,470 --> 00:07:05,770
+جينات عددها كبير الفكرة اللي بدل واحد ياخدها
+
+74
+00:07:05,770 --> 00:07:12,730
+الأولى إنه، يعني أنا بقول هي من جانبين أو هي من
+
+75
+00:07:12,730 --> 00:07:20,970
+مستويين أحنا كنا، يعني طبعاً جزء من الموضوع إنه في
+
+76
+00:07:20,970 --> 00:07:30,040
+مشاركة لعدد كبيرمن الجينات وفي اختلاف في قوة تأثير
+
+77
+00:07:30,040 --> 00:07:36,620
+البدائل الـ Alleles الممكنة لكل جين وبالتالي
+
+78
+00:07:36,620 --> 00:07:47,540
+بيشتركوا في قضية تسبب بالمرض فمثلًا هنا مثال على
+
+79
+00:07:47,540 --> 00:07:56,210
+موقع افتراضي، جين افتراضيلما ندرس الأخوين، نلاقي
+
+80
+00:07:56,210 --> 00:08:02,130
+أنه لمجموعة
+
+81
+00:08:02,130 --> 00:08:06,830
+الجينات
+
+82
+00:08:06,830 --> 00:08:13,810
+نلاقي أنه في تفاوت في البدائل الأليل الممكنة أن
+
+83
+00:08:13,810 --> 00:08:18,210
+بعضها بيكون أقوى في التسبب أو في العلاقة مع مرض
+
+84
+00:08:18,210 --> 00:08:25,690
+معين وبعضها بيكون أقلبعضها بيحمي وبعضها بيسبب وإنه
+
+85
+00:08:25,690 --> 00:08:33,470
+عدد كبير يشترك في التسبب مثال على ذلك الـ Rabo
+
+86
+00:08:33,470 --> 00:08:41,550
+اللي هو قضية التحسس الهوائي وتضيق القصابات بشكل
+
+87
+00:08:41,550 --> 00:08:50,100
+متقطع وكذا نجد إنه بتكونإذا الواحد درس كام جين
+
+88
+00:08:50,100 --> 00:08:55,980
+بيشترك في التسبب بتلاقي حوالي ما يقارب الخمسين جين
+
+89
+00:08:55,980 --> 00:09:03,340
+وبكونوا يعني قوتهم في التسبب كل واحد اللي هو
+
+90
+00:09:03,340 --> 00:09:08,240
+بيمفرد وضعيف يعني وفي تفاوت في الضعف هذا بس لما
+
+91
+00:09:08,240 --> 00:09:13,620
+يكون العدد كبير بشكل معين بتلاقي الرابط بيكون
+
+92
+00:09:13,620 --> 00:09:20,130
+أشويع أو أقوى وكدهفهذه يعني ملاحظة اللي هي إنه عدد
+
+93
+00:09:20,130 --> 00:09:26,650
+كبير من الجينات تشترك الظواهر الثانية أحنا كنا
+
+94
+00:09:26,650 --> 00:09:31,470
+أشارنا إلها من قبل في قضية العلم التخلق أو الـ
+
+95
+00:09:31,470 --> 00:09:38,390
+Epigenetics اللي هي إنه يعني مش فقط التغير
+
+96
+00:09:38,390 --> 00:09:45,230
+البنيوي، التغيرهيكل إلى الجين من ناحية أنه قليل
+
+97
+00:09:45,230 --> 00:09:50,310
+بشكل معين يعني ممكن يعطينا بروتين مختلف مش بس هذا
+
+98
+00:09:50,310 --> 00:09:55,470
+الاختلاف الاختلاف الثاني هي في درجة نشاط الجينات
+
+99
+00:09:55,470 --> 00:10:03,730
+يعني ممكن شخصين نفس الجين، نفس القليل بس لما يكون
+
+100
+00:10:03,730 --> 00:10:10,530
+نشاط شديد بتلاقي مثل المرض موجود نشاط قليل، المرض
+
+101
+00:10:10,530 --> 00:10:16,610
+مش موجودبتكون برضه بهذه الطريقة فقضية التفاوت في
+
+102
+00:10:16,610 --> 00:10:22,070
+نشاط الجينات هذا اللي هو علم الـ Epigenetics وإيه
+
+103
+00:10:22,070 --> 00:10:27,230
+اللي دخل لاحظنا في قضية الـ methylation للـ DNA
+
+104
+00:10:27,230 --> 00:10:32,330
+الـ methylation للـ Histones الـ microRNAs البصمة
+
+105
+00:10:32,330 --> 00:10:35,710
+الوراثية اللي هي الـ Parental Imprinting هذه
+
+106
+00:10:35,710 --> 00:10:38,450
+الأشياء اللي ما فهمناهوش أو ما كانوا للأغلب مش
+
+107
+00:10:38,450 --> 00:10:45,260
+فاهموا، هدولة كلها أشكال فيبتسوي اختلاف في نشاط
+
+108
+00:10:45,260 --> 00:10:54,760
+الجين وبالتالي، يعني هذه برضه لدقل ولها تأثير
+
+109
+00:10:54,760 --> 00:11:02,620
+في قضية حدوث الأمراض لو جينة ناخد، وبصراحة
+
+110
+00:11:02,620 --> 00:11:11,720
+المحاضرة عندكميعني حاطين أمثلة كثيرة بدناش ندخل
+
+111
+00:11:11,720 --> 00:11:20,620
+فيها يعني ما بدي مش هدفنا إنه نطلعكم خبراء بالمجمل
+
+112
+00:11:20,620 --> 00:11:31,620
+الموضوع بشكل تفصيلي عن كام نسبة الحدوث مرض معين في
+
+113
+00:11:31,620 --> 00:11:35,220
+إنسان إذا كان حد من أقاربه عنده نفس المشكلة
+
+114
+00:11:37,960 --> 00:11:45,560
+هذه جدول من أحد المراجع بيمثل
+
+115
+00:11:45,560 --> 00:11:50,560
+الـ Relative أو الـ Risk Ratio اللي هي الإشارة هذه
+
+116
+00:11:50,560 --> 00:11:58,620
+الـ RS أظن هي معناته أو رؤس الـ Risk Ratio هي إذا
+
+117
+00:11:58,620 --> 00:12:05,130
+كان إنسانعنده من أقاربه،
+
+118
+00:12:05,130 --> 00:12:13,410
+يعني من أخوانه
+
+119
+00:12:13,410 --> 00:12:22,250
+و أخواته مباشرة لشخص مصاب بمرض معين كم مضاعفات
+
+120
+00:12:22,250 --> 00:12:29,950
+احتمالية أن يصير عنده هذا المرض مقارنة بغيرهفمثلًا
+
+121
+00:12:29,950 --> 00:12:34,610
+الأمراض النفسية الـ Schizophrenia أو انفسام
+
+122
+00:12:34,610 --> 00:12:42,650
+الشخصية إذا أخ أو أخت مصاب بهذا المرض لشخص مصاب
+
+123
+00:12:42,650 --> 00:12:48,590
+أخوانه و أخواته احتمالية إصابتهم فيها أتناشر ضعف
+
+124
+00:12:48,590 --> 00:12:53,690
+من لو ما كانش فيه قرابة أو ما كانش فيه مرض ضمن
+
+125
+00:12:53,690 --> 00:12:58,390
+العائلة الـ Autism التوحدمن الأمراض النفسية أو
+
+126
+00:12:58,390 --> 00:13:04,150
+السلوكية برضه 150 مرة الـ Manic Depressive Bipolar
+
+127
+00:13:04,150 --> 00:13:09,930
+Disorder برضه من الأمراض النفسية سبع مرات السكر
+
+128
+00:13:09,930 --> 00:13:14,270
+النوع الأول وهو يعتبر يعني مش النوع الوراثة القوى
+
+129
+00:13:14,270 --> 00:13:18,750
+كثير كثير نسبة الحدوث، ورح نشوف إنها دراسة ثانية
+
+130
+00:13:18,750 --> 00:13:22,190
+بالنسبة
+
+131
+00:13:22,190 --> 00:13:29,070
+لما الإنسان يكون أحدأقارب أو أحد أشقائه أو شقيقاته
+
+132
+00:13:29,070 --> 00:13:34,090
+مصاب خمسة وثلاثين مرة مرض Crohn's Disease اللي هو
+
+133
+00:13:34,090 --> 00:13:37,390
+الـ Inflammatory Bowel Disease من أمراض المناعة
+
+134
+00:13:37,390 --> 00:13:42,690
+الباتية على الجهاز الهضمي خمسة وعشرين مرة الـ
+
+135
+00:13:42,690 --> 00:13:46,490
+Multiple Sclerosis أو التصلب اللويحي أربعة وعشرين
+
+136
+00:13:46,490 --> 00:13:52,990
+مرة يعني الملاحظ في كل هذه الأمراض وراح نأخد أمثلة
+
+137
+00:13:52,990 --> 00:13:59,170
+كثيرةأنه مجرد حدوث المرض
+
+138
+00:13:59,170 --> 00:14:04,470
+أو تواجده في العائلة في أحد الأشقاء برفع نسبة
+
+139
+00:14:04,470 --> 00:14:10,710
+احتمالية حدوثه في الأشقاء الآخرين بنسبة عالية جداً
+
+140
+00:14:10,710 --> 00:14:16,710
+وهذا تأثير على دور
+
+141
+00:14:16,710 --> 00:14:21,770
+الوراثة في قضية التسبب بمرض معين
+
+142
+00:14:24,310 --> 00:14:32,110
+فكثير من الأمراض لها دور بس قد يكون قائل يعني اللي
+
+143
+00:14:32,110 --> 00:14:39,870
+هي أن الأشقاء عادة بعيشوا مع بعض وبالتالي بيئتهم
+
+144
+00:14:39,870 --> 00:14:45,490
+متشابهة فقد يكون هذه النسب وهذه الزيادة قد تكون
+
+145
+00:14:45,490 --> 00:14:53,050
+بسبب نمط حياة معين بسبب بيئة معينةبتشاركوا فيها
+
+146
+00:14:53,050 --> 00:14:57,430
+وبالتالي زادت النسبة بسبب المشاركة في البيئة وليس
+
+147
+00:14:57,430 --> 00:15:03,030
+بسبب مشاركة في الجينات يعني الكثير من الظواهر
+
+148
+00:15:03,030 --> 00:15:09,430
+العامة يعني مثلا هنا دراسة عن نسبة الدهول
+
+149
+00:15:09,430 --> 00:15:15,370
+والكلسترول بين الأمهات والأطفال أو الأبناء
+
+150
+00:15:17,820 --> 00:15:23,480
+فيعني عددهم يعني وأنا الأمات بين عمر الـ 30 والـ
+
+151
+00:15:23,480 --> 00:15:30,540
+39 والأبناء بين عمر الأربع سنوات والتسع سنوات وشوف
+
+152
+00:15:30,540 --> 00:15:37,660
+العلاقة بينهم تقريبًا يعني نقدرنا نرسم الخط لـ
+
+153
+00:15:37,660 --> 00:15:45,850
+يعني ما يمثل المجمل العلاقات أنه كل ما كانتالأم
+
+154
+00:15:45,850 --> 00:15:49,730
+الـ «كوليسترول» عندها أعلى «الإبن» برضه عنده الـ
+
+155
+00:15:49,730 --> 00:15:55,030
+«كوليسترول» أعلى فهذه قضية يعني طبعاً في تفاوت
+
+156
+00:15:55,030 --> 00:16:02,730
+شديد بالنقاط حوالين الخط هذا بس واضح إنه الواحد
+
+157
+00:16:02,730 --> 00:16:10,390
+بيشوف إنه بشكل عام كل ما كان القراءة أوطة للأم
+
+158
+00:16:10,390 --> 00:16:16,270
+بتكون للطفل أو للإبن واطيةوكل ما كانت أعلى بتكون
+
+159
+00:16:16,270 --> 00:16:21,370
+للأبن أعلى فأحياناً في علاقات مثل بياتها هذا الشكل
+
+160
+00:16:21,370 --> 00:16:29,490
+اللي بنشوفها وبالتالي بنصير يعني نقيم تأثير سواء
+
+161
+00:16:29,490 --> 00:16:35,970
+بين قوسين الوراثة والبيئة
+
+162
+00:16:37,290 --> 00:16:49,110
+درجة حدوث اللي هو في كام عدد المصابين
+
+163
+00:16:49,110 --> 00:16:56,430
+في العائلة ناخد هنا مثلًا مثال اللي بيسموها الشفاة
+
+164
+00:16:56,430 --> 00:17:03,770
+الأرنبية الـ Cleft Lip and Palate اللي هي يعني عيب
+
+165
+00:17:03,770 --> 00:17:10,840
+خلقي بيكون فيه شق فيهالشفاء العليا بحوالي من الفم
+
+166
+00:17:10,840 --> 00:17:18,560
+وبكون منظر معروف ومشهور فهذه الظاهرة إذا أخدنا
+
+167
+00:17:18,560 --> 00:17:31,340
+دراسة لو كان أخدنا إن إنسان له والد أو والدة واحدة
+
+168
+00:17:31,340 --> 00:17:36,330
+فقط في المصابة، ماشي؟number of affected parents،
+
+169
+00:17:36,330 --> 00:17:41,070
+يا إما صفر، يا إما واحد، يا إما أحيانًا بيحدث إنه
+
+170
+00:17:41,070 --> 00:17:46,770
+أثنين بيتزوجوا عندهم نفس الظاهرة، فإذا كان الأباء
+
+171
+00:17:46,770 --> 00:17:54,330
+بهذا الترتيب، نجد أنه في أحد هذه الدراسات، وجيت
+
+172
+00:17:54,330 --> 00:18:01,170
+أنا أشوف إنه مافيش حد كام عدد اللي بيكونوا مصابين
+
+173
+00:18:01,170 --> 00:18:05,900
+في مثل هذهيعني إنه إذا كانت العائلة ما عندهاش ولا
+
+174
+00:18:05,900 --> 00:18:16,440
+حدا مصاب بشكل مسبق في حالة إنه
+
+175
+00:18:16,440 --> 00:18:21,120
+مافيش ولا ولي أمر أو أب و أم و والدين مصاب
+
+176
+00:18:21,120 --> 00:18:27,640
+احتمالية الإصابة 0.1 يعني اللي هي الـRisk Ratio
+
+177
+00:18:27,640 --> 00:18:34,060
+تلاقيها منخفضة نسبياً جداًلما يكون أحدهما يصبح
+
+178
+00:18:34,060 --> 00:18:39,700
+ثلاثة يعني هذه الضعفة تلاتين مرة ولما يكون الأثنين
+
+179
+00:18:39,700 --> 00:18:44,760
+المضاعفة ثلاثمائة مرة عن الأصل يعني أربعة وثلاثين
+
+180
+00:18:44,760 --> 00:18:53,400
+ضعف عن الـ تلاتمية وأربعين ضعف عن الأولى يعني أو
+
+181
+00:18:53,400 --> 00:18:58,720
+عشر أضعاف عن لما يكون one parent عنده المشكلة إذا
+
+182
+00:18:58,720 --> 00:19:03,300
+كان في one sibling عنده مشكلةالأرقام أعلى، إذا
+
+183
+00:19:03,300 --> 00:19:09,600
+أكثر حتى في العائلة الممتدة بتلاقي النسب لسه كمان
+
+184
+00:19:09,600 --> 00:19:14,880
+أعلى، إذا two siblings إنها أعلى النسب، لما يكون
+
+185
+00:19:14,880 --> 00:19:21,860
+بالذات الوالدين مصابين واخوين مصابين، نسبة الإصابة
+
+186
+00:19:21,860 --> 00:19:30,100
+تقترب من الـ 50% المتوقعة في الحالة
+
+187
+00:19:30,100 --> 00:19:37,700
+هذهفبلاحظ درجة والتواجدها كل ما زاد العدد والتواجد
+
+188
+00:19:37,700 --> 00:19:47,580
+أكثر بتكون نسب الإصابة أعلى فيها فهي مثال على درجة
+
+189
+00:19:47,580 --> 00:19:59,110
+تداخل الـ Penetration أو ظهور الصفة الوراثيةودرجة
+
+190
+00:19:59,110 --> 00:20:03,610
+تواجدها إنه إذا حدثت إنه الحالة موجودة عند
+
+191
+00:20:03,610 --> 00:20:08,930
+الوالدين الأثنين النسب بتكون أعلى بكثير من لو
+
+192
+00:20:08,930 --> 00:20:15,090
+مافيش أي حد عنده المشكلة هذه فهو هنا مثال على الـ
+
+193
+00:20:15,090 --> 00:20:22,410
+Cleft lip وcleft palate وكيف إنها صفة إليها دخل
+
+194
+00:20:22,410 --> 00:20:30,140
+بالوراثةويعني إنه الوراثة
+
+195
+00:20:30,140 --> 00:20:36,340
+بتلعب دور كبير فيها وإن كان يعني ممكن واحد يتكلم
+
+196
+00:20:36,340 --> 00:20:42,120
+عن أشياء أخرى لما
+
+197
+00:20:42,120 --> 00:20:51,190
+نكون الواحد يشوف بالنسبة لصفة وراثية أخرىويشوف لما
+
+198
+00:20:51,190 --> 00:20:58,110
+حكينا مثل قبل شوية عن الصفات
+
+199
+00:20:58,110 --> 00:21:07,050
+الوراثية برجع الواحد يقول سؤال اللي هو مين اللي هم
+
+200
+00:21:07,050 --> 00:21:12,550
+بيكونوا نتيجة البيئة ومين اللي بيكون نتيجة المادة
+
+201
+00:21:12,550 --> 00:21:20,710
+الوراثية أو الجيناتدايماً الـ «زيجوتك توينت»
+
+202
+00:21:20,710 --> 00:21:25,810
+«Mono» أو «Di-zygotic twins» هما اللي بيعطونا كمان
+
+203
+00:21:25,810 --> 00:21:31,190
+فكرة وإن كان فيه دراسة بعدين راح ناخدها هنا كمثال
+
+204
+00:21:31,190 --> 00:21:42,170
+محاولة تفريق أهمية البيئة عن أهمية الوراثة الفكرة
+
+205
+00:21:42,170 --> 00:21:48,580
+في الموضوع أنهكثير من الظواهر لما نأتي نأخذ
+
+206
+00:21:48,580 --> 00:21:57,560
+identical twins زي المثال الأول هنا بتلاقي المادة
+
+207
+00:21:57,560 --> 00:22:05,300
+الوراثية متطابقة ولما نأخذ dizygotic twins يعني
+
+208
+00:22:05,300 --> 00:22:10,320
+هنا زي اللي بالنص بتلاقي فيه تفاوت، فيه اختلافات
+
+209
+00:22:10,320 --> 00:22:14,340
+الـ Monozygotic twins اللي على اليمين وعلى اليسار
+
+210
+00:22:14,910 --> 00:22:25,570
+اللي هما بيكونوا يعني في الحالات هذه بيكونوا
+
+211
+00:22:25,570 --> 00:22:30,970
+يا أما ذكورا أو إناثا متشابهين فبيكونوا من نفس
+
+212
+00:22:30,970 --> 00:22:37,690
+الجنس إذا أحنا بنتفرج على كيف توزيع المادة
+
+213
+00:22:37,690 --> 00:22:43,710
+الوراثية بتلاقي أنه في تطابق شبه كامل بين الطرفين
+
+214
+00:22:44,090 --> 00:22:50,350
+بينما لما يكون بيكونوا
+
+215
+00:22:50,350 --> 00:22:56,830
+يعني شخصين مختلفين يعني المادة الوراثية تبعاتهم
+
+216
+00:22:56,830 --> 00:23:03,630
+مختلفة نتيجة أنه مثلا بويضتين تلقح في حيوانين
+
+217
+00:23:03,630 --> 00:23:10,320
+منويين في نفس المرة مثلا أنه كانت هيكفبينتج عنه
+
+218
+00:23:10,320 --> 00:23:16,360
+إنه كأن هذولة أخوين في بطنين مختلفين فتلاقي فيه
+
+219
+00:23:16,360 --> 00:23:21,920
+فروقات بينهم فمثل هذه الظاهرة تستفاد منها في قضية
+
+220
+00:23:21,920 --> 00:23:30,360
+محاولة دراسة تأثير البيئة من تأثير المادة الوراثية
+
+221
+00:23:33,160 --> 00:23:39,940
+فيه معامل أو ظاهرة الـ Concordance الـ Concordance
+
+222
+00:23:39,940 --> 00:23:46,540
+يعني إذا كان إنسان عنده مرض ضمن أي مجموعة
+
+223
+00:23:46,540 --> 00:23:49,000
+«مونوزايجوتيك» أو «دايزايجوتيك» Twin
+
+224
+00:23:49,000 --> 00:23:49,660
+«مونوزايجوتيك» أو «دايزايجوتيك» Twin
+
+225
+00:23:49,660 --> 00:23:50,180
+«مونوزايجوتيك» أو «دايزايجوتيك» Twin
+
+226
+00:23:50,180 --> 00:23:51,500
+«مونوزايجوتيك» أو «دايزايجوتيك» Twin
+
+227
+00:23:51,500 --> 00:23:53,240
+«مونوزايجوتيك» أو «دايزايجوتيك» Twin
+
+228
+00:23:53,240 --> 00:23:56,720
+«مونوزايجوتيك» أو «دايزايجوتيك» Twin
+
+229
+00:23:56,720 --> 00:24:02,040
+«مونوزايجوتيك» أو «دايزايجوتيك» Twin «مونوزايجوت
+
+230
+00:24:02,560 --> 00:24:09,300
+الـ Dizygotic Twins اللي هما يعني كأنه أخوين برضه
+
+231
+00:24:09,300 --> 00:24:14,680
+فيه نسب هي أقل بس بيظل أكبر بكثير من الـ General
+
+232
+00:24:14,680 --> 00:24:22,340
+Population يعني اللي زي ما لاحظنا من قبل في يعني
+
+233
+00:24:22,340 --> 00:24:26,520
+هاي بعتبرها مش كاملة كثير يعني في شيء أنا دائما
+
+234
+00:24:26,520 --> 00:24:32,890
+بعرفه بحفظه وبقول للطلابلو أخذنا السكر النوع الأول
+
+235
+00:24:32,890 --> 00:24:38,070
+اللي هو سكر الأطفال اللي بيكون فيه تحطيم للـ Beta
+
+236
+00:24:38,070 --> 00:24:42,620
+Cell البنك الرئاسيوبيكون فيش إنسولين وبيصير عندنا
+
+237
+00:24:42,620 --> 00:24:47,820
+مرض السكر النوع الأول أو المؤتمد على الإنسولين،
+
+238
+00:24:47,820 --> 00:24:52,240
+insulin-dependent diabetes mellitus نسبة الـ
+
+239
+00:24:52,240 --> 00:24:56,440
+concordance في الـ monozygotic twins حوالي خمسين
+
+240
+00:24:56,440 --> 00:25:01,040
+بالمية، أنا هيك بذكر الرقم كانوا يعطونا يعنى،
+
+241
+00:25:01,040 --> 00:25:07,340
+بينما لو type 2 diabetes، بيكون نسبة الـ
+
+242
+00:25:07,340 --> 00:25:14,710
+concordance مية بالمية، يعنيإذا كان أخوه أو أخته
+
+243
+00:25:14,710 --> 00:25:20,250
+إذا كانت إينات أو أخوها أو أخوه إذا كان ذكور واحد
+
+244
+00:25:20,250 --> 00:25:23,430
+منهم مصيب بالـ Type 2 Diabetes نسبة الـ
+
+245
+00:25:23,430 --> 00:25:28,110
+Concordance 100% فهي يعني، أنا بعتبرها كانت
+
+246
+00:25:28,110 --> 00:25:33,330
+المفروض تكون أقوى ويمؤشر على إن الـGenetics تلعب
+
+247
+00:25:33,330 --> 00:25:38,810
+دور Multifactorial Disorder فلو
+
+248
+00:25:38,810 --> 00:25:44,800
+نيجي ناخدالقراءات في مناهية دراسة مش أرقام للحفظ
+
+249
+00:25:44,800 --> 00:25:52,360
+بمعنى الحفظ بقدر ما أنه فيه تفاوت وفيه نسب اللي
+
+250
+00:25:52,360 --> 00:25:58,740
+بدنا نلاحظها بس الأهم شيء أنه الـ الـ الـ الـ الـ
+
+251
+00:25:58,740 --> 00:26:04,460
+الـ Dizygotic twins إحتمال مؤشر أكثر على تأثير
+
+252
+00:26:04,460 --> 00:26:10,890
+بيئي معين لأنهم الإخوة والـأخوات والعائلة بتعيش في
+
+253
+00:26:10,890 --> 00:26:15,730
+نفس البيئة في الغالب بيتعرضوا لنفس العوامل الـ
+
+254
+00:26:15,730 --> 00:26:21,810
+Monozygotic twins بيكونوا أن الدور الوراثي أقوى
+
+255
+00:26:21,810 --> 00:26:27,250
+لأن المادة الوراثية متطابقة تماماً فبالتالي بنشوف
+
+256
+00:26:27,250 --> 00:26:33,650
+بالنسبة لكثير من الأمراض نسبة حدوثها أكثر في حالة
+
+257
+00:26:33,650 --> 00:26:37,590
+الـ Monozygotic twins في حد عنده سؤال؟
+
+258
+00:26:46,850 --> 00:26:52,890
+فهذه إحدى الدراسات عن الموضوع هذا في دراسة ثانية
+
+259
+00:26:52,890 --> 00:26:56,730
+بشوفها interesting إن الواحد يعني هيك يتطلع عليها
+
+260
+00:26:56,730 --> 00:27:02,530
+ويشوف شو القيام وشو اللي بتي بيحكوا عنها الآن
+
+261
+00:27:02,530 --> 00:27:08,370
+بالنسبة للوزن أحسن مؤشر للوزن عشان قضية اختلاف
+
+262
+00:27:08,370 --> 00:27:12,310
+وتفاوت الطول اللي هو معامل كتلة الجسم اللي هو
+
+263
+00:27:12,310 --> 00:27:19,540
+الـBody Mass Index الـBody Mass Indexهو الوزن
+
+264
+00:27:19,540 --> 00:27:30,840
+بالكيلو على مربع الطول بالمتر يعني إنسان طوله مثلا
+
+265
+00:27:30,840 --> 00:27:38,460
+نقول متر وسبعين صنطي نقسم وزنه ثمانين كيلو ثمانين
+
+266
+00:27:38,460 --> 00:27:42,200
+كيلو بقول بقسم ثمانين على one point seven في one
+
+267
+00:27:42,200 --> 00:27:48,130
+point seven بكون له معادل معينةالجمال المعامل هذا
+
+268
+00:27:48,130 --> 00:27:52,750
+إنه بيعطيك أرقام معروف مثلًا من 19 لـ 25 هذا
+
+269
+00:27:52,750 --> 00:27:58,950
+الإنسان الطبيعي من 25 ل 30 هي فيه زيادة وزن شويه
+
+270
+00:27:58,950 --> 00:28:06,730
+يعني بيقوله overweight شويه من 30 ل 40 سمنة في
+
+271
+00:28:06,730 --> 00:28:11,580
+عنده obesity فوق الأربعينبيقولوا له «morbidly
+
+272
+00:28:11,580 --> 00:28:16,560
+obese» يعني ناصح كثير كثير بشكل سمنة مرضية قاتلة
+
+273
+00:28:16,560 --> 00:28:24,300
+فلما نيجي ناخد في هذه الدراسة حاولوا يفرقوا بين
+
+274
+00:28:24,300 --> 00:28:27,980
+الـ «مونوزيجوتيك» والـ «دايزيجوتيك» Twin types
+
+275
+00:28:27,980 --> 00:28:35,680
+يعني حاولوا يدرسوا فيها ودرسوا الذكور والإناث أو
+
+276
+00:28:35,680 --> 00:28:41,280
+الـ «مايلز» والـ «فيميلز» Men and Womenودرسوا قضية
+
+277
+00:28:41,280 --> 00:28:46,100
+هل عاشوا مع بعض عايشين مع بعض ولّا مفرقين إذا
+
+278
+00:28:46,100 --> 00:28:53,100
+بعيشوا together يعني يعني عايشين في نفس البيت
+
+279
+00:28:53,100 --> 00:28:57,200
+بيأكلوا من نفس الأكل بعيشوا نفس الطريقة بيركبوا
+
+280
+00:28:57,200 --> 00:29:02,560
+نفس السيارة مثلا بيروحوا ماشي قريبين من بعض إذا
+
+281
+00:29:02,560 --> 00:29:08,570
+عايشين apart يعني مربيين في بيئات مختلفةممكن إنه
+
+282
+00:29:08,570 --> 00:29:15,850
+فيه تفاوت في البيئة تكون أكثر فهو راح يعطينا عدد
+
+283
+00:29:15,850 --> 00:29:24,930
+الأزواج من التوائم وأنواعها بالنسبة لكل مرحلة من
+
+284
+00:29:24,930 --> 00:29:34,450
+الدراسة هنا للـ Women وهنا للـ Men وهنا معامل
+
+285
+00:29:34,450 --> 00:29:43,490
+التطابقماشي بالنسبة للـ «مونوزيجوتيك»
+
+286
+00:29:43,490 --> 00:29:53,110
+نلاحظ أنه لما يكونوا «مونوزيجوتيك» ويكونوا يعني
+
+287
+00:29:53,110 --> 00:29:59,310
+الذكور أو الإناث النسب تقريبًا الثلثين أو أكثر، 74
+
+288
+00:29:59,310 --> 00:30:08,430
+%طبعًا الـ 70% لما نتربّب محلين مختلفين وبالنسبة
+
+289
+00:30:08,430 --> 00:30:13,470
+لما نعاشوا مع بعض حتى 75% يعني تقريبًا قريبين جدًا
+
+290
+00:30:13,470 --> 00:30:19,130
+من بعض بينما الـ Disergotic Twins كأخوة وأخوات
+
+291
+00:30:19,130 --> 00:30:25,390
+مختلفين النسب أقل بكثير فبنقدر الواحد يقول وهذه
+
+292
+00:30:25,390 --> 00:30:30,100
+الملاحظة قطمان الجهة الثانية النسب أقل بكثيرإنه
+
+293
+00:30:30,100 --> 00:30:33,360
+يعني الواحد اللي بدي يقوله إنه الوراثة بتلعب دور
+
+294
+00:30:33,360 --> 00:30:39,060
+كبير يعني الدور الأعظم هي لقضية الوراثة إن حجم
+
+295
+00:30:39,060 --> 00:30:43,860
+الواحد أو وزنه بكون بشكل معين وإن فيه نسبة كبيرة
+
+296
+00:30:43,860 --> 00:30:48,500
+من العامل الوراثي لو قارننا الـ Apart عن Together
+
+297
+00:30:48,500 --> 00:30:54,610
+بكل هاتهم بلاقي إنه فيه نسبةلما يكونوا together،
+
+298
+00:30:54,610 --> 00:31:01,390
+نسبة التطابق بتكون أكبر، أقرب لبعض، ماشي، بالذات
+
+299
+00:31:01,390 --> 00:31:06,650
+بالنسبة للذكور أكثر من الإنات، بس كلها تقريبًا،
+
+300
+00:31:06,650 --> 00:31:14,810
+يعني نسب ضئيلة، هنا 4%، هنا صارت 18%، بس هنا 2% و
+
+301
+00:31:14,810 --> 00:31:20,310
+0%، فرق بين إنه عايشين مع بعض أو يعنياللي بنقدر
+
+302
+00:31:20,310 --> 00:31:27,250
+نستنتجه من هذه مثل هيك أرقام أنه نقول إنه الوراثة
+
+303
+00:31:27,250 --> 00:31:32,710
+إلها دخل بس نسبة بسيط الوراثة اللي هو يعني
+
+304
+00:31:32,710 --> 00:31:38,230
+«monozygotic» أو «dizygotic twins» إله همية كبيرة
+
+305
+00:31:38,230 --> 00:31:43,980
+بس البيئة بتلعب دور ثانوي أو بسيطأو يعني هو شيء
+
+306
+00:31:43,980 --> 00:31:51,360
+مؤثر بس درجته بسيطة بالنسبة على عامل قضية الوزن
+
+307
+00:31:51,360 --> 00:31:57,560
+بين الذكور والإينات فهي ملاحظة يعني إنه الوزن نقدر
+
+308
+00:31:57,560 --> 00:32:04,320
+نستنتج بهذه الطريقة إنه نسبة كبيرة من وزن الإنسان
+
+309
+00:32:04,320 --> 00:32:11,900
+يحدده وراثته وفيه جينات بتتدخل في هذا الموضوعوهي
+
+310
+00:32:11,900 --> 00:32:19,620
+اللي بتكون مؤثرة عليه البيئة بحيث إنه كيف كانوا
+
+311
+00:32:19,620 --> 00:32:27,440
+عايشين وشو بيئتهم لها دور بس نسبته قليلة ويعني
+
+312
+00:32:27,440 --> 00:32:34,660
+تأثيره أضعف بكثير من تأثير الوراثةوالوراثة كمان
+
+313
+00:32:34,660 --> 00:32:39,900
+بالـ «مونوزيجوتك توينز» أقوى من الـ «دايزيجوتك
+
+314
+00:32:39,900 --> 00:32:48,220
+توينز» يعني إنها بشكل ملحوظ فهي كلها أمثلة على
+
+315
+00:32:48,220 --> 00:33:01,040
+خواص طبية جسمانية في جوانب مختلفة على قضية التأثير
+
+316
+00:33:01,750 --> 00:33:07,750
+الوراثة والبيئة من خلال عدد كبير من الجينات مافيش
+
+317
+00:33:07,750 --> 00:33:11,570
+جين محدد، it's not dominant أو recessive زي ما كنا
+
+318
+00:33:11,570 --> 00:33:15,910
+نتكلم في الـMandelian Inheritance ولا هي زي
+
+319
+00:33:15,910 --> 00:33:21,970
+الـChromosomal Diseases اللي كنا نحكي عنها الآن
+
+320
+00:33:21,970 --> 00:33:30,830
+حطين أنثى برضه على أهمية الـ
+
+321
+00:33:34,870 --> 00:33:40,390
+الأمراض والحالات اللي بتدخل فيها الـ
+
+322
+00:33:40,390 --> 00:33:44,750
+Multifactorial Inheritance تدخل فيها عداد كبير من
+
+323
+00:33:44,750 --> 00:33:49,970
+الجينات فالـ Cleft Lip وCleft Bullet الـ
+
+324
+00:33:49,970 --> 00:33:54,500
+Congenital Heart Diseasesأو الـ Neuronal Tube
+
+325
+00:33:54,500 --> 00:33:58,840
+Defects أو الـ Spina Bifida أو الـ Anencephaly أو
+
+326
+00:33:58,840 --> 00:34:04,180
+التسكير أو الـ Biliary Stenosis هنا بتتكلموا على
+
+327
+00:34:04,180 --> 00:34:09,660
+Approximate Population Incidence لكل ألف بني آدم
+
+328
+00:34:09,660 --> 00:34:17,840
+كم نسبة الحالات هذه ويعني بالنسبة لمثل هيك أشياء
+
+329
+00:34:17,840 --> 00:34:19,900
+يعني
+
+330
+00:34:22,190 --> 00:34:28,150
+مرة أخرى، عدد كبير من الجينات بتدخل فيها مرات
+
+331
+00:34:28,150 --> 00:34:31,390
+بيقعدوا يبحثوا فيها بالذات إذا في عائلة معينة
+
+332
+00:34:31,390 --> 00:34:35,270
+عندها مشكلة معينة أكثر من غيرها، أقوى من غيرها
+
+333
+00:34:35,270 --> 00:34:43,150
+والشغل الثاني، بدي الواحد يتذكر إنه أحياناً البيئة
+
+334
+00:34:43,150 --> 00:34:48,450
+برضه إلها دخل يعني الـSpina Bifida يعني من الحالات
+
+335
+00:34:48,450 --> 00:34:54,110
+أو الأمراضمثلًا، الأعمل قينة إلها دخل كبير بنقص
+
+336
+00:34:54,110 --> 00:34:58,610
+الـ «فولات» في التخزيه عند الحمل، في الحوامل عشان
+
+337
+00:34:58,610 --> 00:35:02,670
+هيك، إذا بتتم تعويض الـ «فولات» مع الحديد عادةً
+
+338
+00:35:02,670 --> 00:35:07,350
+عشان يعني الدم، نتكلم عنها بس أظن فيه دراسات قوية
+
+339
+00:35:07,350 --> 00:35:13,230
+إن الـ «أسباينة» بيفدأ إذا الواحد بيفرض في المجتمع
+
+340
+00:35:13,230 --> 00:35:20,600
+إنه يعطي تعويض الحواملفي قضية
+
+341
+00:35:20,600 --> 00:35:24,560
+الـ Vital Folate في أحد الفيتامينات اللي بيكون
+
+342
+00:35:24,560 --> 00:35:29,920
+فيها نقص الـ Neuronal Tube Defect بتقل كثير ويكون
+
+343
+00:35:29,920 --> 00:35:36,600
+في اكتمال بناء الجهاز العصبي فهذه أنثى على حالات
+
+344
+00:35:36,600 --> 00:35:46,590
+وبتكون فيها Multifactorial أنا بظن أنه الـالأرقام
+
+345
+00:35:46,590 --> 00:35:59,870
+والتفاصيل بالنسبة لقداش احتمالية حدوث شيء في حالة
+
+346
+00:35:59,870 --> 00:36:06,350
+وجوده في أحد الأقارب أو في أحد الإخوة وقداش نسبته
+
+347
+00:36:06,350 --> 00:36:11,110
+أكثر بتزيد وكذا وكذا، ما بدنا إياها بقدر ما أنه
+
+348
+00:36:11,110 --> 00:36:18,260
+ناخد أن هذه مثالة علىحالة عبارة عن إيها دخل
+
+349
+00:36:18,260 --> 00:36:24,080
+بالنسبة للوراثة بالنسبة للـ Congenital Heart
+
+350
+00:36:24,080 --> 00:36:29,980
+Diseases الـ Tetralogy of Fallot اللي هو ربعية
+
+351
+00:36:29,980 --> 00:36:37,980
+Fallot أربع ظواهر Aortic Stenosis Ventricular
+
+352
+00:36:37,980 --> 00:36:43,130
+Septal Defect Overriding of the Aortaالـ Pulmonary
+
+353
+00:36:43,130 --> 00:36:46,710
+valve
+
+354
+00:36:46,710 --> 00:36:54,410
+stenosis والـ Atrial alarm يعني أربع ظواهر بخربط
+
+355
+00:36:54,410 --> 00:37:00,750
+الدموي بهذا الشكل بيصير سيانوسس بيصير خربطات
+
+356
+00:37:00,750 --> 00:37:06,350
+بالنسبة للقلب بشكل كبير كثير Hypoplastic lymph
+
+357
+00:37:06,350 --> 00:37:12,010
+vent heartيعني فيه مشكلة إنه تكون الـ left
+
+358
+00:37:12,010 --> 00:37:16,870
+ventricle بيصير ضعيف في حالة بيسموها aseptal
+
+359
+00:37:16,870 --> 00:37:24,270
+defect عبارة عن الفتحة بين الأذينين اليمين واليسار
+
+360
+00:37:24,270 --> 00:37:30,610
+اللي هي بتكون أصلاً مهمة في حالة الـ في المرحلة
+
+361
+00:37:30,610 --> 00:37:35,050
+الجنينية المرحلة الجنينية يعني أحنا ماعناش lungs
+
+362
+00:37:35,050 --> 00:37:40,250
+تاخد هووالإنسان في بطن أمه وفي الرحم فالـ
+
+363
+00:37:40,250 --> 00:37:45,430
+Oxygenated blood بيجي من الـ umbilical vein برجع
+
+364
+00:37:45,430 --> 00:37:53,670
+من الـ umbilica، من المشكيبة فالـ Oxygenated blood
+
+365
+00:37:53,670 --> 00:38:00,910
+اللي هو بيجي عن طريق الـ يعني هنا بدي يرجع للقلب
+
+366
+00:38:00,910 --> 00:38:07,940
+على الجهة اليمين عاديبروح بالإنسان الطبيعي، بدخل
+
+367
+00:38:07,940 --> 00:38:11,260
+من الـInferior Vena Cava بروح على طول على الـLeft
+
+368
+00:38:11,260 --> 00:38:13,880
+Atrium، على الـRight Atrium، بعدين على الـLeft
+
+369
+00:38:13,880 --> 00:38:17,180
+Atrium، بعدين على الـBody، هذا اللي هو الدم
+
+370
+00:38:17,180 --> 00:38:21,060
+الكويس، بتكون بهذا الشكل Co-architecture of the
+
+371
+00:38:21,060 --> 00:38:26,740
+aorta، برضه يعني ممكن تكون patent ductus
+
+372
+00:38:26,740 --> 00:38:32,220
+arteriosus، هذوله يعني برضه من الظواهر، هنا فيه
+
+373
+00:38:32,220 --> 00:38:39,600
+تضييبفي الأورطة
+
+374
+00:38:39,600 --> 00:38:44,800
+بعد اللفت subclavian وتكون على الـ anatomical site
+
+375
+00:38:44,800 --> 00:38:49,360
+تبع الدفتس أرتيوزس تبع الدفتس أرتيوزس هذه النقطة
+
+376
+00:38:49,360 --> 00:38:53,400
+الثانية اللي بتتم فيها تحويلات الدم في الفترة
+
+377
+00:38:53,400 --> 00:38:58,000
+الجنينية لما الإنسان يولد كل هذه المفروض تسكر فإذا
+
+378
+00:38:58,000 --> 00:39:02,280
+ما سكرتش أو سكرت زيادة بتعمل مرضالـ Arregulation
+
+379
+00:39:02,280 --> 00:39:04,920
+of the aorta بدي يخلّي الإنسان عنده ارتفاع في
+
+380
+00:39:04,920 --> 00:39:09,380
+الضغط في الأطراف العلوية وبالرجلين الضغط بيكون
+
+381
+00:39:09,380 --> 00:39:14,760
+واطق كثير لأن الدم مش قادر ينضخ بشكل سليم والـ
+
+382
+00:39:14,760 --> 00:39:19,220
+Patent of Arteriosis راح تخلي هبوط في الدورة
+
+383
+00:39:19,220 --> 00:39:26,420
+الدموية بسبب اختلاط الدم بين الدورة الكبرى والصغرى
+
+384
+00:39:26,420 --> 00:39:32,590
+وتكون بشكل متعب للقلب بسببيعني إنه بيشتغل على
+
+385
+00:39:32,590 --> 00:39:38,350
+الفاضي واختلال في دورة الدم فهذه كلها حالات في
+
+386
+00:39:38,350 --> 00:39:47,190
+منها إلها دخل بالنسبة للوراثة ويعني اللي
+
+387
+00:39:47,190 --> 00:39:52,910
+هي بيسموها الـ Risk Ratio كمعامل يعطينا كم مرة
+
+388
+00:39:52,910 --> 00:39:57,030
+أكثر من غيرهإذا كان لدى أحد في العائلة مشكلة
+
+389
+00:39:57,030 --> 00:40:00,950
+بالنسبة
+
+390
+00:40:00,950 --> 00:40:07,890
+للـ Population إذا كان لدى أحد في العائلة مشكلة
+
+391
+00:40:07,890 --> 00:40:13,630
+بالنسبة للحدوث في أبناء الآخرين يعني هنا كلها
+
+392
+00:40:13,630 --> 00:40:15,530
+مثلًا
+
+393
+00:40:16,730 --> 00:40:21,310
+النسب أقل يعني عشر بالمية وواحد بالألف وواحد
+
+394
+00:40:21,310 --> 00:40:26,410
+بالعشر تلات هنا بتصير كـPercentage إذا في واحد
+
+395
+00:40:26,410 --> 00:40:31,670
+مصاب بتوصل لثلاث بالمية أو أربع بالمية وهذه النسبة
+
+396
+00:40:31,670 --> 00:40:40,990
+ترتفع بـ30، 40، 50% زيادة فالـVSD أو الـCongenital
+
+397
+00:40:40,990 --> 00:40:45,530
+Heart Diseases إيه اللي دخل؟ وحكينا يعني مثال على
+
+398
+00:40:46,230 --> 00:40:50,270
+إذا بيذكروا الواحد من الـ Digorge Syndrome كيف إنه
+
+399
+00:40:50,270 --> 00:41:00,450
+فعلاً الوجود وجود حقيقةً subchromosomal deletion
+
+400
+00:41:00,450 --> 00:41:06,750
+وجودها بيخلّي أنه بيصير عند الطفل أو الـ newborn
+
+401
+00:41:06,750 --> 00:41:11,950
+congenital heart disease وهذه من المشاكل نتيجة
+
+402
+00:41:11,950 --> 00:41:13,630
+المادة الوراثية
+
+403
+00:41:17,260 --> 00:41:23,440
+الـ Schizophrenia والـ Bipolar Disorder برضه إلها
+
+404
+00:41:23,440 --> 00:41:29,260
+نسب عالية يعني تفاصيلها أمثلة على يعني ما بديهاش
+
+405
+00:41:29,260 --> 00:41:34,680
+أثبات أخذنا كلام عليها من قبل قضية الـ Coronary
+
+406
+00:41:34,680 --> 00:41:42,940
+Arthral Disease يعني اللي هي تسلط شراين القلب وشو
+
+407
+00:41:42,940 --> 00:41:53,590
+دخله وكذاهي دايماً التاريخ العائلي وحدوثها في قريب
+
+408
+00:41:53,590 --> 00:41:57,670
+من الدرجة الأولى حكيناها الأباء والأمهات والإخوان
+
+409
+00:41:57,670 --> 00:42:03,310
+والخوات والولاد والبنات دولة لأي إنسان بيكون من
+
+410
+00:42:03,310 --> 00:42:10,010
+عوامل الخطورة لتصلب شرايين الدم هذا برضه بيكون
+
+411
+00:42:10,010 --> 00:42:20,140
+موجودفهنا دراسات أخرى يعني الـ Monozygotic twins
+
+412
+00:42:20,140 --> 00:42:26,000
+إذا في واحد عنده إصابة، الثاني تقريبًا من ثمن إلى
+
+413
+00:42:26,000 --> 00:42:32,820
+خمستاشر مرة الإصابة بتكون أكبر، إذا Dizygotic
+
+414
+00:42:32,820 --> 00:42:40,660
+twins من مرتين لثلاثةمضاعفات في احتمالية الإصابة
+
+415
+00:42:40,660 --> 00:42:47,280
+بالتصلب الشرايين وبعدين حدوث احتشاق في عضلة القلب
+
+416
+00:42:47,280 --> 00:42:53,560
+ماشي هنا بـFatal Early Fatal Myocardial Infarction
+
+417
+00:42:53,560 --> 00:42:57,880
+يعني كانت نتيجة الوفاة كمان يعني نوعية شديدة أو
+
+418
+00:42:57,880 --> 00:43:05,820
+درجة شديدة من التصلب الشرايينفتصلب الشراين برضه
+
+419
+00:43:05,820 --> 00:43:13,320
+تتدخل فيه جينات كثيرة بس كمان فيه تأثيرات بيئية
+
+420
+00:43:13,320 --> 00:43:17,960
+كثيرة وهو من الحالات والمشاكل اللي نسميها
+
+421
+00:43:17,960 --> 00:43:22,700
+Multifactorial والـ Multifactorial جزء منه قضية
+
+422
+00:43:22,700 --> 00:43:27,020
+الورافة، نعم، فيه أسئلة
+
+423
+00:43:32,180 --> 00:43:37,620
+حالة أخرى Retinitis Pigmentosa بتكون من المسببات
+
+424
+00:43:37,620 --> 00:43:45,200
+من المسببات المرض
+
+425
+00:43:45,200 --> 00:43:51,100
+في الإبصار وإن واحد بيشوفش يعني هنا حاطينه مثال
+
+426
+00:43:51,100 --> 00:43:59,340
+على دراسة معينة كانت بسبب Diagenetic Inheritance
+
+427
+00:44:00,450 --> 00:44:07,670
+يعني هنا مثال لما اندرسوا عائلة لقوا عبارة عن كمان
+
+428
+00:44:07,670 --> 00:44:10,810
+اللي عامل الحالة هذه اللي هو Retinitis Pigmentosa
+
+429
+00:44:10,810 --> 00:44:18,510
+التلطخ أو تصبغ الشبكية تصبغ الشبكية في اللي هو
+
+430
+00:44:18,510 --> 00:44:27,850
+الـGene الأول ROM1والثاني اسمه الـ Peripheral
+
+431
+00:44:27,850 --> 00:44:37,650
+Locus اللي هو الجين الثاني وكيف انه تداخل الحالتين
+
+432
+00:44:37,650 --> 00:44:45,010
+يعني هنا داخلين أكثر في دراسة عن هذه الحالة علشان
+
+433
+00:44:45,010 --> 00:44:51,580
+يشوفوا أيش السببوإيش الـ «جين» اللي سببها في هذه
+
+434
+00:44:51,580 --> 00:44:58,260
+العائلتين يعني غير محظوظين إنه الناس عندهم بالأخير
+
+435
+00:44:58,260 --> 00:45:04,380
+موقعين مختلفين وبعاد تماماً بيأثروا على نفس الجهة
+
+436
+00:45:04,380 --> 00:45:11,840
+اللي هي الإبصار والشبكية في العيل فحيث إنه كانت
+
+437
+00:45:11,840 --> 00:45:23,200
+إنه سببت المرض لما نيجي ناخدكمان في الحالات
+
+438
+00:45:23,200 --> 00:45:32,160
+الوراثية بالنسبة للـ Clotting Factors اللي هو نقص
+
+439
+00:45:32,160 --> 00:45:38,380
+في الـ Factor 8 وFactor 9 اللي هم الـ Hemophilia
+
+440
+00:45:38,380 --> 00:45:43,100
+اللي هي قضية بنسميها النعور باللغة العربية النسف
+
+441
+00:45:43,100 --> 00:45:48,500
+الشديد وعدم تكون جلطات الدم وغيرهلما ندرس هذا
+
+442
+00:45:48,500 --> 00:45:55,500
+الموضوع لأ، فيه كمان جوانب أخرى على تجلط الدم اللي
+
+443
+00:45:55,500 --> 00:46:00,260
+دخل بطريقة Multifactorial وإنه دخل فيها أشياء
+
+444
+00:46:00,260 --> 00:46:06,040
+كثيرة فاكتر فايف لايدن، فيه الو Variant
+
+445
+00:46:06,040 --> 00:46:13,620
+وبروثرومبين، اللي هو الـFactor 2 اللي هو الرقم 2،
+
+446
+00:46:13,620 --> 00:46:19,270
+ماشي، برضه الو Variantالـ Fibrinogen رقم 1
+
+447
+00:46:19,270 --> 00:46:22,650
+فالتفاوت
+
+448
+00:46:22,650 --> 00:46:31,050
+في الـ Variation بالنسبة للـ Clotting Factor
+
+449
+00:46:31,050 --> 00:46:35,610
+Geneticsاللي له تداخل كمان بالـ Environmental
+
+450
+00:46:35,610 --> 00:46:40,070
+Factors مثال عليها كـ Environmental Factors أحد
+
+451
+00:46:40,070 --> 00:46:43,370
+أهم أسباب التجلطات اللي هو استخدام الـ Oral
+
+452
+00:46:43,370 --> 00:46:51,410
+Contraceptive Pills اللي هو الحب تمنع الحمل كهرمون
+
+453
+00:46:51,410 --> 00:46:59,650
+ثيرابي عشان يمنع الحمل فالفكرة
+
+454
+00:46:59,650 --> 00:47:01,530
+في الموضوع أنه
+
+455
+00:47:05,490 --> 00:47:12,810
+حسب الـ «جينيتيك فاكتور» والـ «جينيتيك ستاتوس»
+
+456
+00:47:12,810 --> 00:47:18,450
+وبعده بشكل متعدد العامل
+
+457
+00:47:18,450 --> 00:47:22,990
+البيئي زي الـ Oral Contraceptives بتلاقي إله دخل
+
+458
+00:47:22,990 --> 00:47:27,160
+إنه بيعمل مشاكلفالـ Factor 10 اللي ما محطينكم
+
+459
+00:47:27,160 --> 00:47:31,740
+إياها والـ Prothrombin اللي هو Factor 2 هدولة
+
+460
+00:47:31,740 --> 00:47:36,880
+ازدادوا بشكل كبير مع بعض الـ Variants of them مع
+
+461
+00:47:36,880 --> 00:47:41,980
+الـ Oral Contraceptivesفهي بتسبب إنه
+
+462
+00:47:41,980 --> 00:47:46,040
+«hypercoagulable state» يعني بتسبب إنه راح تسمح
+
+463
+00:47:46,040 --> 00:47:51,700
+إنه يصير جلطات وتصير مشاكل بسبب
+
+464
+00:47:51,700 --> 00:47:58,660
+تداخل عوامل وراثية وعوامل بيئية من الآن الأشياء
+
+465
+00:47:58,660 --> 00:48:02,060
+اللي تعتبر قوية في الأماكن دا في عند الواحد مجال
+
+466
+00:48:02,060 --> 00:48:11,340
+لدراستها اللي هو تأثيرالـ Warfarin على الـ الـ
+
+467
+00:48:11,340 --> 00:48:15,460
+طبعاً الـ Warfarin هو Blocker للـ Vitamin K اللي
+
+468
+00:48:15,460 --> 00:48:20,560
+هو بيثبت الـ Vitamin K dependent factors والواحد
+
+469
+00:48:20,560 --> 00:48:28,600
+بيحفظه كمعادلة أو كرقم 1972 فعشرة أو تسعة أو سبعة
+
+470
+00:48:28,600 --> 00:48:31,900
+أو اثنين كل ال factors تبعات الـ Coagulation
+
+471
+00:48:31,900 --> 00:48:36,260
+factors produced by the liver بتم إنتاجها من الكبد
+
+472
+00:48:36,740 --> 00:48:41,620
+والأربع هدولة Vitamin K-dependent طبعاً زاد بروتين
+
+473
+00:48:41,620 --> 00:48:47,380
+C وبروتين S فالآن فيه side effect قوي وبتصير مشاكل
+
+474
+00:48:47,380 --> 00:48:52,100
+من الوارثارين إذا فيه certain genetic mutation
+
+475
+00:48:52,100 --> 00:48:56,560
+فحتى من الآن اللي يسمونه personalized medicine
+
+476
+00:48:56,560 --> 00:49:04,140
+الأصل أنه يعني يدوروا على الـGenetic mutation هذه
+
+477
+00:49:04,600 --> 00:49:07,900
+وإذا فعلاً الإنسان عنده إياهة
+ما يعطوه الـ
+
+478
+00:49:07,900 --> 00:49:14,940
+Warfarin وبتأثر على كمية أو كيفية معالجته بالنسبة
+
+479
+00:49:14,940 --> 00:49:19,780
+للـ Carbohydrate
+
+480
+00:49:19,780 --> 00:49:28,540
+Factors في أسئلة؟ في حالة اسمها Herschsprung
+
+481
+00:49:28,540 --> 00:49:36,060
+Disease Herschsprung Disease من أمراضالجهاز الهضمي
+
+482
+00:49:36,060 --> 00:49:40,680
+والـ Motility تبعت الجهاز الهضمي برضه اللي دخل
+
+483
+00:49:40,680 --> 00:49:47,560
+بالبيئة وكمان أمراض كثيرة زي الـ Type 1 Diabetes
+
+484
+00:49:47,560 --> 00:49:51,780
+الـ Alzheimer وDementia
+
+485
+00:49:51,780 --> 00:50:02,000
+كيف إنه عدد كبير من الـ Genotypes جينات متعددة
+
+486
+00:50:02,400 --> 00:50:08,980
+طبعًا يعني مثلًا موضوع زي الـ Alzheimer اللي هو
+
+487
+00:50:08,980 --> 00:50:13,900
+الأصل يعني اللي واحد يتذكره كـPresenal Dementia
+
+488
+00:50:13,900 --> 00:50:19,900
+يعني الخرف المبكر الإنسان
+
+489
+00:50:19,900 --> 00:50:28,940
+حسب بيئته، حسب جيناته، حسب شو هو بتلاقي فيه تفاوت
+
+490
+00:50:28,940 --> 00:50:36,620
+في نسبة حدوث هذه الحالةوبتلاقي تعتمد
+
+491
+00:50:36,620 --> 00:50:45,700
+حسب يعني عدد مش قليل من الـ الـ mutations وكذا
+
+492
+00:50:45,700 --> 00:50:50,600
+ولكن أيضًا إله دخل بالبيئة يعنيزي ما دائمًا بيحكوا
+
+493
+00:50:50,600 --> 00:50:54,760
+كثير إذا مثلًا واحد بيحفظ قرآن إذا الواحد دائمًا
+
+494
+00:50:54,760 --> 00:51:00,880
+بنشط عقله مثلًا بيلعب لعبة زي اللي فيها رياضيات
+
+495
+00:51:00,880 --> 00:51:06,180
+وتفكير وحساب زي لعبة سودوكو مثلًا ودائمًا بيظل
+
+496
+00:51:06,180 --> 00:51:14,440
+يمرن عقله الإنسان بتلاقي بأخر حدوث الخرف وبيظل
+
+497
+00:51:14,440 --> 00:51:20,370
+محاصر على قوة العقلية مدة أطول أحيانًا زي ذلكفكل
+
+498
+00:51:20,370 --> 00:51:29,910
+أشياء أمثلة على أمراض وحالات بيكون
+
+499
+00:51:29,910 --> 00:51:34,170
+الصفة
+
+500
+00:51:34,170 --> 00:51:42,550
+الأغلب فيها والأعام هي أنها تشترك فيها جوانب
+
+501
+00:51:42,550 --> 00:51:50,820
+وراثية وجوانب جينيةبطرق مختلفة ومتفاوتة ومتعددة مع
+
+502
+00:51:50,820 --> 00:51:55,220
+عوامل بيئية بتلاقيها في البيئة في أشياء معينة
+
+503
+00:51:55,220 --> 00:51:59,860
+بتخلي الواحد يسير عنده فبالنسبة لمحاضرة اليوم هذه
+
+504
+00:51:59,860 --> 00:52:09,460
+الأشياء اللي أمثل عليها يعني أنا بظن إن الواحد إذا
+
+505
+00:52:09,460 --> 00:52:15,060
+بده يركز شوية على إن الأمثل الكرومزومية يحفظها
+
+506
+00:52:15,060 --> 00:52:22,670
+مظبوطلأن عددها قليل وأمثلتها قليلة بالذات الرئيسية
+
+507
+00:52:22,670 --> 00:52:28,770
+منها وبالنسبة لـ «ماندالين» يتكلم عن مشهورات منهم
+
+508
+00:52:28,770 --> 00:52:36,130
+المعرفات والأساسيات وبالنسبة للمجموعة الكبرى يعني
+
+509
+00:52:36,130 --> 00:52:43,270
+كل الأسماء الأمراض اللي عرضناهم يتذكر الواحد إنه
+
+510
+00:52:43,270 --> 00:52:45,570
+Multifactorial
+
+511
+00:52:46,510 --> 00:52:51,090
+ما دخلناش كثير في مثال مثلًا مثلًا مثلًا مثلًا
+
+512
+00:52:51,090 --> 00:52:51,650
+مثلًا مثلًا مثلًا مثلًا مثلًا مثلًا مثلًا مثلًا
+
+513
+00:52:51,650 --> 00:52:56,810
+مثلًا مثلًا مثلًا مثلًا مثلًا
+
+514
+00:52:56,810 --> 00:53:01,150
+مثلًا
+
+515
+00:53:01,150 --> 00:53:02,270
+مثلًا مثلًا مثلًا مثلًا مثلًا مثلًا مثلًا مثلًا
+
+516
+00:53:02,270 --> 00:53:03,410
+مثلًا مثلًا مثلًا مثلًا مثلًا مثلًا مثلًا مثلًا
+
+517
+00:53:03,410 --> 00:53:13,030
+مثلًا مثلًا
+
+518
+00:53:13,030 --> 00:53:19,260
+مثلًاالـ Whole Genome Sequencing يعني أنه تقدر
+
+519
+00:53:19,260 --> 00:53:25,780
+الواحد يقرأ شو نيوكليوتاد تبع كل الـ DNA تبع أي
+
+520
+00:53:25,780 --> 00:53:34,400
+إنسان، ماشي، بصير تعطيني يعني مرجع إن إذا أنا عند
+
+521
+00:53:34,400 --> 00:53:40,460
+عائلة كبيرة مثلا أو مجموعة معينة من البشروبكون
+
+522
+00:53:40,460 --> 00:53:46,180
+أقدر أقارن بين المصابين وغير المصابين ليش هذا أصيب
+
+523
+00:53:46,180 --> 00:53:52,600
+وليش هذا لم يصيب في الـ Whole Genome Sequencing من
+
+524
+00:53:52,600 --> 00:53:58,520
+أحد التقنيات اللي راحت تشوفوا أنها بتقدر تفيدها
+
+525
+00:53:58,520 --> 00:54:09,180
+وفي جانب آخر قضية دراسة كمية شغل الـ Geneيعني مش
+
+526
+00:54:09,180 --> 00:54:14,420
+كل الـ «جين» في كل الخلايا شغالة بنفس الدرجة لأ،
+
+527
+00:54:14,420 --> 00:54:18,400
+حسب مثلا الـ «جين» تبع الـ «هيموجلوبين» بضرب دائما
+
+528
+00:54:18,400 --> 00:54:22,720
+مثال بس في الـ «رد بلد سيلز» بيكون شغال في باقية
+
+529
+00:54:22,720 --> 00:54:27,900
+الخلايا ما له دخله، بقى بتم استخدامه فحتى بالنسبة
+
+530
+00:54:27,900 --> 00:54:33,860
+لـ «هيموجلوبين» الـ «جين» درجة فعليته كم نسخة RNA
+
+531
+00:54:33,860 --> 00:54:40,330
+ناتج عنهفبالتالي، يعني ممكن الإنسان العالم يعني
+
+532
+00:54:40,330 --> 00:54:45,510
+قصدي في الدراسة نشوف اختلاف أو تفاوت في نشاط
+
+533
+00:54:45,510 --> 00:54:48,250
+الجينات اللي هو يعني الـ Epigenetic Control اللي
+
+534
+00:54:48,250 --> 00:54:56,750
+حكينا عنه هذه لها طرق دراسة معينة ممكن نتيجتها
+
+535
+00:54:56,750 --> 00:55:02,730
+الواحد يكون يعرف إيش الجينات المسؤولة بنشاطة عن
+
+536
+00:55:02,730 --> 00:55:09,030
+حدوث مرض معينيعني هذه الـ الـ يعني الـ gene
+
+537
+00:55:09,030 --> 00:55:18,510
+expression بتكون إنه إحنا بندرس بشكل عام درجة نشاط
+
+538
+00:55:18,510 --> 00:55:25,260
+الجينات كلها بمين اللي زايدات ومين اللي ناقصاتوهذه
+
+539
+00:55:25,260 --> 00:55:31,400
+بتكون باستخدام Markers معينة وبتكون أساليب دراسة
+
+540
+00:55:31,400 --> 00:55:38,920
+لما واحد يقرأ عنها بتلاقيها ممكن تكون مفيدة فاليوم
+
+541
+00:55:38,920 --> 00:55:44,620
+المحاضرة قصيرة، مافيش فيها أفكار كثيرة بالنسبة
+
+542
+00:55:44,620 --> 00:55:51,400
+لـ’’ يعني بالنسبة لـ’’ أنه المطلوب بالنسبة للجينات
+
+543
+00:55:51,400 --> 00:55:55,630
+لهذهالأمراض، لأ، ما بيداشيها كثير كثير يعني
+
+544
+00:55:55,630 --> 00:56:00,430
+بالنسبة شوهيها بقدر ما أنه فيه عدد كبير من الجينات
+
+545
+00:56:00,430 --> 00:56:03,870
+يعني أقل واحد واللي حطوا عنه مثال اللي هو الـ
+
+546
+00:56:03,870 --> 00:56:08,010
+Retinitis Pigmentosa إنه فيها جينين عملات مشكلة
+
+547
+00:56:08,010 --> 00:56:11,430
+فيه
+
+548
+00:56:11,430 --> 00:56:18,650
+أسئلة أسئلة عن الجزء هذا أو الأجزاء السابقة
+
+549
+00:56:31,300 --> 00:56:39,220
+هنا، دعنا نشوف، Remote Control، Chat،
+
+550
+00:56:39,220 --> 00:56:47,860
+ماشي، دكتور أحمد، في أسئلة؟ اليوم، الحلقة أقصر من
+
+551
+00:56:47,860 --> 00:56:54,620
+غيرها شوية، أصل مفاهيمها يعني، الحمد لله، يعني
+
+552
+00:56:54,620 --> 00:56:57,700
+مطلوب المعلومة العامة يعني، أه
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/d-MRFWD54MU.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/d-MRFWD54MU.srt
new file mode 100644
index 0000000000000000000000000000000000000000..317016afc93fd1fef3b8a306b0444a42a937ac97
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/d-MRFWD54MU.srt
@@ -0,0 +1,3548 @@
+1
+00:00:00,000 --> 00:00:03,920
+وهو الـ Single Gene Inheritance اللي هما الـ
+
+2
+00:00:03,920 --> 00:00:10,240
+Mandelian Diseases حكيت أنا يعني من قبل أنه في عندنا
+
+3
+00:00:10,240 --> 00:00:15,460
+عدد أمثلة قليل عادةً لـ Chromosomal Diseases الـ
+
+4
+00:00:15,460 --> 00:00:20,580
+Chromosomal Diseases لما يكون كروموزوم كامل أو جزء
+
+5
+00:00:20,580 --> 00:00:27,980
+من كروموزوم بيصير فيه مشكلة زي Deletion، Copy
+
+6
+00:00:27,980 --> 00:00:37,440
+Number زيادة في عدده، خربطة في القطعة بتكون فيها
+
+7
+00:00:37,440 --> 00:00:45,000
+مشكلة كبيرة بتكون، وعادةً يعني هذول الأمراض ما يعني
+
+8
+00:00:45,000 --> 00:00:52,400
+صحيح يعني أمثلة واضحة وكبيرة ويكون فيها مشاكل
+
+9
+00:00:52,400 --> 00:00:57,320
+كثيرة، بس في الغالب هي بالـ Newborns بتسبب
+
+10
+00:00:57,320 --> 00:01:04,100
+Abortions عادةً ما بتكون لأسباب تتعلق باحتمالية
+
+11
+00:01:04,100 --> 00:01:12,000
+أن يكون موجود في شخص حي بعد ذلك، إلا إذا صارت
+
+12
+00:01:12,000 --> 00:01:16,340
+إشكالية أو مشكلة في قضية أنه يكون Balanced
+
+13
+00:01:16,340 --> 00:01:21,940
+Translocation يعني في قطعة رايحة من مكانها الصحيح
+
+14
+00:01:21,940 --> 00:01:27,390
+مفقودة، بس بتكون في مكان آخر، فكلها أمثلة على الـ
+
+15
+00:01:27,390 --> 00:01:31,810
+Chromosomal Diseases، وأخذنا مثال على الـ
+
+16
+00:01:31,810 --> 00:01:35,570
+Subchromosomal Diseases، الـ DiGeorge Syndrome بذكركم
+
+17
+00:01:35,570 --> 00:01:39,390
+فيه، لأنه فيه مبادئ كثيرة بتفيدكم في الـ Immunology
+
+18
+00:01:39,390 --> 00:01:43,470
+كمان، ومفيدة الآن الـ Mendelian Diseases الـ
+
+19
+00:01:43,470 --> 00:01:50,130
+Mendelian Diseases برضه يعني أنه Disease أو مشكلة
+
+20
+00:01:50,130 --> 00:01:57,000
+نتيجة خلل في جين واحد. الـ Group الثالث اللي راح
+
+21
+00:01:57,000 --> 00:02:02,200
+ناخذه بعدين، واللي هي أشمل بشكل أكبر بكثير كعدد
+
+22
+00:02:02,200 --> 00:02:06,760
+ولكن يمكن
+
+23
+00:02:06,760 --> 00:02:11,860
+دراستها صعبة من ناحية أنه مش جين واحد المسؤول، لما
+
+24
+00:02:11,860 --> 00:02:15,980
+يشارك عدد كبير من الجينات، يعني زي في الـ Bronchial
+
+25
+00:02:15,980 --> 00:02:20,260
+Asthma، الربو القصبي، تقريبًا فيه حوالي خمسين جين
+
+26
+00:02:20,260 --> 00:02:24,810
+بيشاركوا، فتلاقي عدد كبير من الجينات كلهم مشاركين
+
+27
+00:02:24,810 --> 00:02:31,150
+بتسبب بالمرض أو تتسبب بإعطائنا الصفة الفلانية، فإحنا
+
+28
+00:02:31,150 --> 00:02:39,310
+دايمًا لما نتكلم عن مبادئ المناعة الوراثية نتكلم
+
+29
+00:02:39,310 --> 00:02:44,430
+عن أنه فيه Genotype و Phenotype لما ندرس بشكل
+
+30
+00:02:44,430 --> 00:02:50,880
+تفصيلي ودقيق، الجينات، وكيف شكلها، وكيف ترتيبها، وماذا
+
+31
+00:02:50,880 --> 00:02:55,120
+بتعطي، وماذا بتسوي، هذا بيكون اسمه الـ Genotype.
+
+32
+00:02:55,120 --> 00:03:01,020
+وأحيانًا أكثر من Genotype يعطينا Phenotype واحد، أو
+
+33
+00:03:01,020 --> 00:03:05,820
+كيف كل... يعني شو المظهر الأخير راح يكون، على زي
+
+34
+00:03:05,820 --> 00:03:11,540
+مثلاً هنا شكل الإنسان، شكل أنفه، شكل جلده،
+
+35
+00:03:11,540 --> 00:03:16,570
+طوله، عرضه، وكذا وكذا، كلها بتلاقيها أمور مرتبطة
+
+36
+00:03:16,570 --> 00:03:21,430
+بالجينات، وبتكون أنه فيه علاقة بين الـ Genotype
+
+37
+00:03:21,430 --> 00:03:25,850
+والـ Phenotype. هذه قضية مهمة من القضايا المهمة
+
+38
+00:03:25,850 --> 00:03:32,250
+الثانية، الواحد يفهم بالنسبة
+
+39
+00:03:32,250 --> 00:03:35,670
+لمن
+
+40
+00:03:35,670 --> 00:03:42,240
+يتعرض لحالة زي هيك، أو إذا بدي يكون له دور يسبب
+
+41
+00:03:42,240 --> 00:03:46,040
+تقدم الواحد في الطب والعلم من ناحية الأمراض
+
+42
+00:03:46,040 --> 00:03:52,840
+الوراثية، أنه من أول ما تجيني الحالة وخلال ما عندي
+
+43
+00:03:52,840 --> 00:03:58,000
+أشخاص أحياء عندهم معلومات وكذا، برسم شجرة العائلة.
+
+44
+00:03:58,000 --> 00:04:05,400
+شجرة العائلة اللي هي بنسميها الـ Pedigree لها رموز،
+
+45
+00:04:05,400 --> 00:04:11,430
+الواحد يكون فاهمها. لما نشوف رموز المربع، هذا
+
+46
+00:04:11,430 --> 00:04:17,250
+Male، المدائرة هي Female. إذا حاطينها شكل معين، مش
+
+47
+00:04:17,250 --> 00:04:26,230
+محدد، إحنا ماشيين على الرموز هذه ومعانيها، وهذه،
+
+48
+00:04:26,230 --> 00:04:28,990
+يعني، راح نستفيد منها على الأقل في المحاضرة
+
+49
+00:04:28,990 --> 00:04:33,960
+القادمة. المحاضرة هذه، في أن كيف منها نستنتج ما هي
+
+50
+00:04:33,960 --> 00:04:39,020
+نوعية الـ Inheritance؟ ما هي نوعية الـ Mendelian
+
+51
+00:04:39,020 --> 00:04:42,740
+Diseases؟ هل هي سائدة (dominant) أو مرتبطة بالـ X (X-linked) أو متنحية (recessive)؟ ما هي وصفها، بحسب ما بكون
+
+52
+00:04:42,740 --> 00:04:46,580
+أنا بشوفه، بحسب الـ degree اللي برسمه، نتيجة أن
+
+53
+00:04:46,580 --> 00:04:50,880
+أنا أخذت المعلومات الكاملة من المريض، أهل المريض،
+
+54
+00:04:50,880 --> 00:04:56,920
+آبائه، أجداده، أبنائه، أحفاده، إخوانه، وكذا. بحاول
+
+55
+00:04:56,920 --> 00:05:03,900
+أخذ المعلومات الكاملة، فهذه ناحية مهمة جدًا، وهكذا
+
+56
+00:05:03,900 --> 00:05:09,040
+معاني الرموز المستخدمة في الـ pedigree chart أو في
+
+57
+00:05:09,040 --> 00:05:16,540
+شجرة العائلة اللي لازم ترسم، وبكون لها معاني مهمة
+
+58
+00:05:16,540 --> 00:05:22,460
+وهي شغلة مهمة، دكتور، فيه إمكانية تعمل share screen
+
+59
+00:05:22,460 --> 00:05:28,960
+لأن...؟ أنا هأحاول، مش موجود، مش مبين، دقيقة،
+
+60
+00:05:28,960 --> 00:05:35,870
+آسف، إيه؟ وين؟ إيه؟ Zoom؟
+
+61
+00:05:35,870 --> 00:05:47,090
+ليش بيكلمني يـSign in؟ ده كيف؟ إيه؟
+
+62
+00:05:47,090 --> 00:05:57,630
+ليش بيكلمني يـ Sign in؟ ده كيف؟ إيه؟
+
+63
+00:06:02,350 --> 00:06:11,950
+Share screen، Share
+
+64
+00:06:11,950 --> 00:06:16,130
+screen، Share
+
+65
+00:06:16,130 --> 00:06:16,310
+screen، Share screen، Share screen، Share screen، Share
+
+66
+00:06:16,310 --> 00:06:16,730
+screen، Share screen، Share screen، Share screen، Share
+
+67
+00:06:16,730 --> 00:06:17,250
+screen، Share screen، Share screen، Share screen، Share
+
+68
+00:06:17,250 --> 00:06:22,070
+screen، Share screen، Share screen، Share screen، Share
+
+69
+00:06:22,070 --> 00:06:25,750
+screen
+
+70
+00:06:25,750 --> 00:06:30,170
+Share screen، Share screen، Share screen، Share screen،
+
+71
+00:06:30,170 --> 00:06:35,140
+Share screen، معاني الرموز المستخدمة: Divorced،
+
+72
+00:06:35,140 --> 00:06:39,820
+Married، Consanguinity (زواج قارب)، Dizygotic،
+
+73
+00:06:39,820 --> 00:06:44,380
+Monozygotic، Adopted into family، Adopted out of
+
+74
+00:06:44,380 --> 00:06:53,090
+family. إذا في عملية تبني داخل أو خارج العائلة. في
+
+75
+00:06:53,090 --> 00:06:56,030
+الـ Proband اللي هي الحالة الأولى اللي تم
+
+76
+00:06:56,030 --> 00:07:01,510
+اكتشافها، وعلى ضوئها تم دراسة وضع العائلة هذه أو
+
+77
+00:07:01,510 --> 00:07:07,290
+الاهتمام بها. فكل جوانب لازم الواحد يعرفها، إحنا
+
+78
+00:07:07,290 --> 00:07:16,970
+يعني هنا المبدأ الثاني في شجرة العائلة غير قضية
+
+79
+00:07:16,970 --> 00:07:23,840
+الـ "نفهمهم، شوفوا كيف معناته، كيف صارت". قضية
+
+80
+00:07:23,840 --> 00:07:28,240
+الـ، يعني أحيانًا بنقول "3rd degree"، "2nd degree"،
+
+81
+00:07:28,240 --> 00:07:33,540
+"3rd degree relative" بهذا الشكل. لما مثلًا أنا
+
+82
+00:07:33,540 --> 00:07:40,580
+أتكلم عن احتمالية الإصابة في تصلب الشرايين التاجية مرتبط
+
+83
+00:07:40,580 --> 00:07:46,020
+بأن التاريخ العائلي يعني من العوامل الخطورة الكبرى
+
+84
+00:07:46,020 --> 00:07:51,400
+الـ Major Risk Factors. قضية أنه يكون أنا Family
+
+85
+00:07:51,400 --> 00:07:54,850
+History. فالـ Family History يعرف على أنه "first
+
+86
+00:07:54,850 --> 00:07:59,010
+degree relative sudden death" أو "MI" "at young
+
+87
+00:07:59,010 --> 00:08:05,590
+age" أقل من 55 للـ females و 45 للـ males مثلاً.
+
+88
+00:08:05,590 --> 00:08:09,410
+فالتعريف هذا، الـ definition هذا بيشترط "first
+
+89
+00:08:09,410 --> 00:08:13,390
+degree relative". فلو أخذنا الشخص هذا اللي موجود
+
+90
+00:08:13,390 --> 00:08:18,150
+عنده سهم، فبتلاقي الـ first degree هم إخوانه
+
+91
+00:08:18,150 --> 00:08:23,640
+و أخواته، حقين عليه first degree، والده ووالدته
+
+92
+00:08:23,640 --> 00:08:29,840
+وأولاده وبناته، هذول الـ First-degree relatives اللي
+
+93
+00:08:29,840 --> 00:08:36,620
+هي أنثى، فزوجها لا يعتبر First-degree relative. زوج
+
+94
+00:08:36,620 --> 00:08:41,220
+بنتها لا يعتبر First-degree relative، بينما مثلًا
+
+95
+00:08:41,220 --> 00:08:45,920
+جدها وجدتها من ناحية الأب والأم هي Second-degree
+
+96
+00:08:45,920 --> 00:08:53,880
+relatives. حاطين عمها Second-degree، مثلًا حفيدها
+
+97
+00:08:53,880 --> 00:09:01,540
+Second-degree، ماشي. وإذا في مثلًا ابن عم، يعني هو
+
+98
+00:09:01,540 --> 00:09:07,080
+أنا بالنسبة إليها الـ Proband أو اللي هنا هذا
+
+99
+00:09:07,080 --> 00:09:12,040
+أبوها، هذا عمها، ابن عمها درجة ثالثة، ابن ابن عمها
+
+100
+00:09:12,040 --> 00:09:19,340
+درجة رابعة. فأحيانًا بيكون شخص مشترك من أكثر من جهة
+
+101
+00:09:19,340 --> 00:09:30,780
+يعني مثلًا أخوها تزوج بنت خالة
+
+102
+00:09:30,780 --> 00:09:35,260
+بنت
+
+103
+00:09:35,260 --> 00:09:45,920
+خالة أمها، أمها يعني هذا أخوها، هذه أمها، وهذه أخوها
+
+104
+00:09:45,920 --> 00:09:53,000
+فهو بيصير بالنسبة لهذا الرجل هذا خاله، وبالتالي إذا
+
+105
+00:09:53,000 --> 00:09:58,900
+أخذت بنت خاله فهي درجة ثالثة بالنسبة للـ Proband
+
+106
+00:09:58,900 --> 00:10:04,680
+من الدرجة الثالثة. ولما نلاقي هذا الـ Double
+
+107
+00:10:04,680 --> 00:10:10,520
+Marriage، يعني Consanguinity، يعني زواج أقارب،
+
+108
+00:10:10,520 --> 00:10:16,800
+فباخذه بهذا الشكل. فـ يعني إحنا لما نيجي نتطلع على
+
+109
+00:10:16,800 --> 00:10:21,210
+الـ Pedigree شجرة العائلة، المفروض نكون قادرين على فهم
+
+110
+00:10:21,210 --> 00:10:27,730
+الرموز واستيعابها، ويعني معرفة معانيها، وكيف نرمز
+
+111
+00:10:27,730 --> 00:10:32,950
+لكل علاقة مطلوبة، فهذه نواحي مهمة حتى نستطيع بعدين
+
+112
+00:10:32,950 --> 00:10:39,750
+نعرف شو نوعية الـ Inheritance. مثال على مواضيع الـ
+
+113
+00:10:39,750 --> 00:10:46,170
+Inheritance ماشي اللي هو الـ ABO Blood Group، الـ
+
+114
+00:10:46,170 --> 00:10:50,470
+ABO Blood Group، نفس الـ Group هي Carbohydrate
+
+115
+00:10:50,470 --> 00:10:57,430
+Antigen. لما نتكلم على جين، هو يمثل أو راح يعطي
+
+116
+00:10:57,430 --> 00:11:03,090
+البروتين، البروتين في الحالة هذه هو الـ Enzyme، يا
+
+117
+00:11:03,090 --> 00:11:07,130
+أما الـ A-Enzyme يا أما الـ B-Enzyme. الـ Enzyme
+
+118
+00:11:07,130 --> 00:11:10,530
+هذا بيغير الـ Structure تبع الـ Carbohydrate
+
+119
+00:11:10,530 --> 00:11:14,130
+Antigen اللي بيسموه الـ H-Antigen اللي موجود بالـ
+
+120
+00:11:14,130 --> 00:11:18,760
+O Blood Group، يحولونه إلى A-antigen أو B-antigen.
+
+121
+00:11:18,760 --> 00:11:25,720
+فإذا الإنسان عنده two alleles AB، وراثهم راح يطلع
+
+122
+00:11:25,720 --> 00:11:30,180
+الـ Phenotype AB، لأن إثنينهم co-dominant لما
+
+123
+00:11:30,180 --> 00:11:34,240
+يكونوا إثنين موجودين. فالمبدأ يعني بين الـ A والـ O
+
+124
+00:11:34,240 --> 00:11:40,060
+والـ B والـ O، إن الـ A أو الـ B dominant على الـ O، الـ O
+
+125
+00:11:40,060 --> 00:11:44,460
+هو الـ recessive، والـ A والـ B dominant، بس بين الـ A
+
+126
+00:11:44,460 --> 00:11:48,740
+والـ B فيه co-dominant، يعني إذا فيه إثنين، إثنين
+
+127
+00:11:48,740 --> 00:11:55,180
+راح يبقوا إثنينهم. فهي ناحية مهمة، ودايمًا أنا بقول في
+
+128
+00:11:55,180 --> 00:12:00,220
+مواضيع المناعة ومواضيع الوراثة ومواضيع أشياء كثيرة
+
+129
+00:12:00,220 --> 00:12:05,760
+في الدنيا، Transplantation، Transfusion، يظل الـ ABO
+
+130
+00:12:05,760 --> 00:12:08,740
+System very، very important، الواحد لازم يكون فاهمه
+
+131
+00:12:08,740 --> 00:12:14,520
+كويس. فالـ ABO System one of the earliest systems
+
+132
+00:12:14,520 --> 00:12:19,860
+يعني "لاندشتاينر" العالم اللي اكتشف الـ ABO system
+
+133
+00:12:19,860 --> 00:12:26,060
+أخذ جائزة نوبل سنة 1900، يعني قبل 120 سنة، عشان
+
+134
+00:12:26,060 --> 00:12:31,760
+اكتشافه، لأنه بيحدد لنا كيف علاقات blood transfusion
+
+135
+00:12:31,760 --> 00:12:34,820
+فالأصل
+
+136
+00:12:34,820 --> 00:12:41,260
+الإنسان لما يعني يكون عنده blood group معينة، والـ
+
+137
+00:12:41,260 --> 00:12:46,760
+antigens في خلاياه، أنه ما في خلايا مناعية تتعرف على self
+
+138
+00:12:46,760 --> 00:12:52,640
+الأصل، بتتم القضاء عليها في مرحلة مبكرة. فاللي عنده
+
+139
+00:12:52,640 --> 00:13:00,100
+A، الخلايا اللي كانت ممكن تتفاعل مع الـ A، يعني
+
+140
+00:13:00,100 --> 00:13:05,720
+من ناحية المناعة، بتتم القضاء عليها. عشان هيك في
+
+141
+00:13:05,720 --> 00:13:10,040
+الـ serum، في الـ antibody، عنده بيكون عنده Anti-B،
+
+142
+00:13:10,040 --> 00:13:16,070
+وما عندهوش Anti-A. عندما أشخص أو أقوم بالـ type
+
+143
+00:13:16,070 --> 00:13:21,670
+للإنسان هذا، بحط Anti-A و Anti-B على خلايا من عندي
+
+144
+00:13:21,670 --> 00:13:29,170
+من الـ Blood-Group Reagent Anti-A و Anti-B، فبيصير
+
+145
+00:13:29,170 --> 00:13:33,290
+عنده Reaction للـ A، وما فيش Reaction للـ B، Anti-B
+
+146
+00:13:33,290 --> 00:13:37,450
+الـ O، ما فيش Reaction للطرفين. الـ B بالعكس، والـ AB
+
+147
+00:13:37,450 --> 00:13:43,340
+بتفعل مع إثنينهم. الـ AB في الـ serum عنده ما فيه Anti
+
+148
+00:13:43,340 --> 00:13:51,280
+-A ولا فيه Anti-B. فهذه قضية يعني بتكون موجودة
+
+149
+00:13:51,280 --> 00:13:56,720
+وتكون بهذه الطريقة وبهذا الشكل. فهذا مثال على
+
+150
+00:13:56,720 --> 00:14:06,540
+locus، يعني على مكان للجينات هذه، وفي عندنا three
+
+151
+00:14:06,540 --> 00:14:12,510
+alleles possible، يعني الـ Genotypes اللي هو القليل
+
+152
+00:14:12,510 --> 00:14:17,870
+الممكن في هذا المكان: يا O يا A يا B، والـ
+
+153
+00:14:17,870 --> 00:14:22,930
+Phenotypes الممكن أربعة: يا O يا A يا B يا
+
+154
+00:14:22,930 --> 00:14:29,310
+AB، مع ملاحظة أنه لما يكون A، لأن الـ A
+
+155
+00:14:29,310 --> 00:14:32,190
+dominant على الـ O، في الـ possibilities تكون
+
+156
+00:14:32,190 --> 00:14:37,830
+AA أو AO، والـ B لما يكون الـ Phenotype B
+
+157
+00:14:37,830 --> 00:14:43,380
+يا إما BB كـ Genotype أو BO كـ Genotype، فهي
+
+158
+00:14:43,380 --> 00:14:50,780
+المفاهيم لازم الواحد يكون مستوعبها وسهلة وغاضبة عنده
+
+159
+00:14:50,780 --> 00:14:59,220
+فـ لما نيجي نشوف كيف بيصير الـ Inheritance وعلى أي
+
+160
+00:14:59,220 --> 00:15:08,020
+أساس، يعني أنا بصير بعدين أحكم إنه هاي هيك، هاي
+
+161
+00:15:08,020 --> 00:15:16,500
+هيك، هاي هيك. لو أخذنا مثلًا مثال، نرجع بعد شوية بقى
+
+162
+00:15:16,500 --> 00:15:23,780
+دي، أنا بشوف عندي إنسان في الحالة هذه شخصين من أسرة
+
+163
+00:15:23,780 --> 00:15:31,400
+مصابين، ولد وابنة، ماشي؟ أو يعني حتى صاروا كبار في العمر
+
+164
+00:15:31,400 --> 00:15:36,600
+بحيث أنه البنت هذه أو المرأة هذه حتى عندها ثلاث
+
+165
+00:15:36,600 --> 00:15:44,440
+أولاد وبنت، يعني صارت أم. لما أشوف أنا بـ pedigree
+
+166
+00:15:44,440 --> 00:15:53,620
+بهذا الشكل، أول شيء الإصابة بين ذكور وإناث، يعني ما
+
+167
+00:15:53,620 --> 00:16:00,350
+أفرقت بين الذكر والأنثى، هذا مؤشر على أنه "it is
+
+168
+00:16:00,350 --> 00:16:06,450
+autosomal"، "it is not X-linked". لو X-linked كانت
+
+169
+00:16:06,450 --> 00:16:10,630
+بتلاقي الواحد فرق كبير أو فرق شديد، إن مثلًا الذكور
+
+170
+00:16:10,630 --> 00:16:14,270
+مصابين، والإناث ما فيش ولا واحدة مصابة. لما يكون
+
+171
+00:16:14,270 --> 00:16:20,550
+الإصابة بين الجنسين متساوي أو ممكنة، بس بفكر أكثر
+
+172
+00:16:20,550 --> 00:16:26,310
+أنها "it is autosomal". القضية الثانية هي أنه يعني
+
+173
+00:16:26,310 --> 00:16:33,750
+هذه الظاهرة ماشي؟ لما أنا آجي أدرسها، هلاقي إن الأب
+
+174
+00:16:33,750 --> 00:16:37,610
+والأم اللي هو أنا
+
+223
+00:20:53,160 --> 00:20:58,060
+والشغل الثاني، في الـ possibilities يعني لازم
+
+224
+00:20:58,060 --> 00:21:02,780
+الواحد حتى يجيب الاحتمالية بشكل دقيق لازم يكون
+
+225
+00:21:02,780 --> 00:21:08,060
+يعرف هل هو بما أنه recessive ففيه بالنسبة للإنسان
+
+226
+00:21:08,060 --> 00:21:13,640
+اللي مش مصاب فيه possibility إنه يكون يا إما يعني
+
+227
+00:21:13,640 --> 00:21:20,900
+dominant الاثنين، two copies وبالتالي ما عندهوش ما
+
+228
+00:21:20,900 --> 00:21:26,440
+عندهوش جين مصاب أو بيكون carrier فهذه اللي بتفرق
+
+229
+00:21:26,440 --> 00:21:30,400
+اللي ليه المجهولحيانًا من ناحية الـ genotype و
+
+230
+00:21:30,400 --> 00:21:35,430
+الـ phenotype أيوة كريم، أحكي ده شو ended في حد رفع
+
+231
+00:21:35,430 --> 00:21:40,950
+يده؟ في
+
+232
+00:21:40,950 --> 00:21:46,630
+أسئلة؟ أنا تمام، يا عزيزي يا دكتور الله عفوا،
+
+233
+00:21:46,630 --> 00:21:51,710
+عشوائية، يمكن نتفضل الحالة الأولى، اللي فوق الـ
+
+234
+00:21:51,710 --> 00:21:56,130
+carrier  الـ «Rr، Rr»
+
+235
+00:21:56,130 --> 00:22:02,310
+هي نسبة غالبينها بإنه «هما» مش مصابين unaffected
+
+236
+00:22:02,310 --> 00:22:07,250
+نعمل، وواحد تبقى affected ولّا لازم نذكر أنه… ما
+
+237
+00:22:07,250 --> 00:22:15,110
+فهمت عليك السؤال، ما فهمت
+
+238
+00:22:15,110 --> 00:22:21,870
+السؤال لسه، عيد السؤال، الحالة الأولى، ما لها؟
+
+239
+00:22:21,870 --> 00:22:26,310
+هلجيت؟ لما كنا ندرس الـ genetics قبل أيام
+
+240
+00:22:26,310 --> 00:22:30,270
+المدرسة، كنا ناخد إن اللي فوق يكون مثلاً 525، ثلاثة
+
+241
+00:22:30,270 --> 00:22:34,140
+لواحد، لكن هاد أنت الـ unaffected carriers
+
+242
+00:22:34,140 --> 00:22:38,100
+بنعتبرها لحظة مثلاً في النسبة اللي قدام في الأسئلة
+
+243
+00:22:38,100 --> 00:22:41,040
+أو في الاختبارات، لازم نحكي أن الـ unaffected
+
+244
+00:22:41,040 --> 00:22:44,980
+carrier نص والـ unaffected لحالها ربع والـ
+
+245
+00:22:44,980 --> 00:22:49,640
+unaffected لحالها ربع، ولكن أنت اللي فوق مع بعض
+
+246
+00:22:49,640 --> 00:22:57,520
+لأ، إذا في سؤال طالب بشكل تفصيلي يعني أنت هنا مهيمن
+
+247
+00:22:57,520 --> 00:23:05,400
+بيني ربعه 3.5% unaffected يعني الـ unaffected 75%
+
+248
+00:23:05,400 --> 00:23:10,260
+والـ affected دلوقت بس
+
+249
+00:23:10,260 --> 00:23:16,180
+الفكرة يعني في ملاحظة اللي هي إنك أنت لو ما نقول
+
+250
+00:23:16,180 --> 00:23:21,250
+مثلاً والله احتمالية تجيب الحامل ولد ولا بنت نص، مش
+
+251
+00:23:21,250 --> 00:23:26,330
+بالضرورة إنه لو جابت أربعة من قبل ذكور، الأخيرة
+
+252
+00:23:26,330 --> 00:23:31,310
+لازم تطلع أنثى، أو ممكن تطلع كذا يعني شو الإنسان
+
+253
+00:23:31,310 --> 00:23:35,930
+بيطلع مدى ما فيه احتمالية ربع، عشر، كذا يمكن هذا
+
+254
+00:23:35,930 --> 00:23:40,210
+الاحتمال يتطلع كل مرة يعني ممكن يصير يعني فهي هذه
+
+255
+00:23:40,210 --> 00:23:45,410
+النقطة، أما الأرقام اللي موجودة بهذا الشكل آه لازم
+
+256
+00:23:45,410 --> 00:23:49,850
+تعرفها بهذا الشكل، إذا أنا سألتك كم unaffected في
+
+257
+00:23:49,850 --> 00:23:56,090
+الحالة الأولى، بدك تقول لي 75%؟ لأنه النص والربع
+
+258
+00:23:56,090 --> 00:24:00,610
+75% أنا
+
+259
+00:24:00,610 --> 00:24:04,750
+مش مستيقظ، يا دكتور، نعم، يعني شغلكم في المدارس كان
+
+260
+00:24:04,750 --> 00:24:10,450
+صحيح، بس التفصيل،
+
+261
+00:24:10,450 --> 00:24:15,070
+إذا عند الواحد قالي درس الجينات ويعرف إنه هل
+
+262
+00:24:15,070 --> 00:24:20,170
+الـcarrier اللي أمامه carrier ولا completely normal
+
+263
+00:24:20,770 --> 00:24:27,630
+ماشي، هاي بدك يكون الواحد من تباهي لها فالإحتمالات
+
+264
+00:24:27,630 --> 00:24:32,370
+في الجداول هذه هي للـ autosomal recessive diseases
+
+265
+00:24:32,370 --> 00:24:37,270
+ماشي، والفكرة الأساسية فيها زي ما فرجينا هنا بالـ
+
+266
+00:24:37,270 --> 00:24:42,010
+pedigree هذا إن الذكور والإناث متساوين، يعني من
+
+267
+00:24:42,010 --> 00:24:48,220
+ناحية احتمالية القدرة على حمل الجين الموروث التابع
+
+268
+00:24:48,220 --> 00:24:57,760
+للمرض وبكونه affected بشكل متشابه، ماشي، لما نكون،
+
+269
+00:24:57,760 --> 00:25:04,060
+يعني ناحية مهمة كثير لما نتكلم على إنه autism and
+
+270
+00:25:04,060 --> 00:25:10,080
+recessive، قضية الـ consanguinity، الـ consanguinity
+
+271
+00:25:10,080 --> 00:25:19,440
+من أهم الظواهر بصراحة في دول ثانية مثلاً
+
+272
+00:25:19,440 --> 00:25:25,680
+عند الروس الناس بسمع عنهم بشكل معين، الروس بنت العم
+
+273
+00:25:25,680 --> 00:25:31,600
+وبنت الخال والأقارب بهذا الدرجة بالنسبة إلينا زي
+
+274
+00:25:31,600 --> 00:25:37,080
+الأخر يعني ما بيفكر واحد منهم يتزوج بنت عمه وبنت
+
+275
+00:25:37,080 --> 00:25:41,500
+خاله بهذا الدرجة، يعني إذا بده يتزوج بيبعد كثير
+
+276
+00:25:41,500 --> 00:25:47,880
+كثير، يعني حتى في ثقافات معينة قضية زواج الأقارب
+
+277
+00:25:47,880 --> 00:25:52,820
+ودرجتها يعني بتلاقيهم بيبعدوا أكثر بكثير منها
+
+278
+00:25:52,820 --> 00:25:58,360
+وعندهم يعني زواج الأقارب درجة ولاد العم وابنات
+
+279
+00:25:58,360 --> 00:26:03,760
+العم لأ غير مقبول يعني، مع أنه يعني الواحد منا
+
+280
+00:26:03,760 --> 00:26:09,420
+بعرف قصص ولاد سيدنا آدم عليه السلام أول ما بدؤا كان
+
+281
+00:26:09,420 --> 00:26:14,360
+الأخ يأخذ أخته يعني من بطن ثاني يعني لما كانوا
+
+282
+00:26:14,360 --> 00:26:22,000
+يجيبوا في بداية البشرية يعني فقضية الـ
+
+283
+00:26:22,000 --> 00:26:29,440
+consanguinity قضية مهمة وبتأشر على الـ autosomal
+
+284
+00:26:29,440 --> 00:26:34,180
+recessive inheritance، والسبب إنه الـ carriers
+
+285
+00:26:34,180 --> 00:26:39,760
+أحياناً بتكون احتماليتها في المجتمع قليلة بحيث إذا
+
+286
+00:26:39,760 --> 00:26:45,000
+ما كان زواج أقارب وكذا بيصير احتمالية إن اثنين
+
+287
+00:26:45,000 --> 00:26:51,500
+carriers يتجوزوا بعض بتكون احتمالية نادرة، فهي برضه
+
+288
+00:26:51,500 --> 00:26:56,780
+بتعطينا مثال على autosomal recessive inheritance
+
+289
+00:26:56,780 --> 00:27:02,340
+راح ناخد بعدين أمثلة على شو يعني بعض الأمثلة في
+
+290
+00:27:02,340 --> 00:27:11,120
+الأشياء الثانية، والفكرة أنه الـ يعني الـ autosomal
+
+291
+00:27:11,120 --> 00:27:15,520
+بتكون الذكر والأنثى زي بعض، لما ناخد الـ autosomal
+
+292
+00:27:15,520 --> 00:27:22,180
+dominant inheritance اللي هي بتكون على العكس، وجود
+
+293
+00:27:22,180 --> 00:27:27,040
+one copy of the disease is enough to manifest the
+
+294
+00:27:27,040 --> 00:27:34,020
+disease، لأنه هو dominant، ماشي، فإذا أخدنا شخص مصاب
+
+295
+00:27:34,790 --> 00:27:41,970
+اللي هو في الحالة هذه D-capital وD-small بيكون
+
+296
+00:27:41,970 --> 00:27:47,650
+الجنود استبعاته D-capital في نص الصميم وD-small في نص
+
+297
+00:27:47,650 --> 00:27:56,680
+ثاني، ويزوج مع شخص آخر أو متزوجة أخرى، زوجته small
+
+298
+00:27:56,680 --> 00:28:01,720
+capital small D small D بهذا الشكل، راح ينتج
+
+299
+00:28:01,720 --> 00:28:08,460
+عنه إنه نص الأطفال مصابين ونص الأطفال غير مصابين
+
+300
+00:28:08,460 --> 00:28:15,120
+لما أشوف أنا هذه النسب وفي الحالة هذه بتكون الذكور
+
+301
+00:28:15,120 --> 00:28:22,840
+والإناث زي بعض، ما في أي تأثير للجنس على القضية هذه
+
+302
+00:28:24,440 --> 00:28:30,940
+فهذه في حالة إذا مصاب اتزوج إنسان طبيعي، الطبيعي
+
+303
+00:28:30,940 --> 00:28:44,620
+لازم يكون Dd، في حالة اثنين مصابين ويكون عندهم Dd
+
+304
+00:28:44,620 --> 00:28:49,800
+بهذا الشكل، يكون الـ genotype تبعهم، في الحالة هذه
+
+305
+00:28:50,660 --> 00:28:58,380
+إذا كان زواج بهذه الطريقة بالنسبة لما نكون
+
+306
+00:28:58,380 --> 00:29:04,380
+strictly dominant يعني قضية
+
+307
+00:29:04,380 --> 00:29:12,460
+أنه أحياناً الـ dominance يعني مش ظاهرة دائمًا 100
+
+308
+00:29:12,460 --> 00:29:19,420
+%، يعني مثلاً لما نيجي مثلاً تختار باللي على طول قضية
+
+309
+00:29:19,420 --> 00:29:26,350
+الصلع، فيه جينات معينة لما تكون عند الرجال بيكون
+
+310
+00:29:26,350 --> 00:29:31,190
+عندهم جين الصلع على طول بيبين لو كان يعني بيصير
+
+311
+00:29:31,190 --> 00:29:36,730
+dominant بينما نفسه نفسه في الـ female، recessive
+
+312
+00:29:36,730 --> 00:29:41,070
+في حيث أنه بتلاقي بالـ female بدك two doses من الـ
+
+313
+00:29:41,070 --> 00:29:45,610
+disease gene حتى يبين الصلع بشكل درجة أقل من الرجل
+
+314
+00:29:45,610 --> 00:29:51,360
+فأحياناً في عوامل أخرى بتتدخل فيها، فإذا هنا افترضنا
+
+315
+00:29:51,360 --> 00:29:57,940
+strictly dominant يعني بظهر
+
+316
+00:29:57,940 --> 00:30:01,680
+بشكل قوي جداً وبتكفي نسخة واحدة تعطينا المرض
+
+317
+00:30:01,680 --> 00:30:06,760
+وانتهينا، فراح يصير عندي إنه ثلاثة أرباع من
+
+318
+00:30:06,760 --> 00:30:13,660
+الـaffected راح يكونوا affected سواء DD بالربع
+
+319
+00:30:13,660 --> 00:30:22,130
+أو Dd بالنصف اللي هم هذول المجموعة، وبكون الربع
+
+320
+00:30:22,130 --> 00:30:25,110
+unaffected dd يعني بيظل فيه
+
+321
+00:30:25,110 --> 00:30:31,050
+احتمال إنه يطلع من أبنائهم وبناتهم إنسان ما عندهوش
+
+322
+00:30:31,050 --> 00:30:35,450
+المرض، في حالة ما بيكون incompletely dominant
+
+323
+00:30:35,450 --> 00:30:43,590
+يعني بتصير إنه الـ DD بيفرق عن الـ Dd
+
+324
+00:30:43,590 --> 00:30:49,650
+فبيصير الربع severely affected ونصف الـ affected
+
+325
+00:30:49,650 --> 00:30:55,190
+بس الربع unaffected بيكون هاته التقسيمات وهذا
+
+326
+00:30:55,190 --> 00:31:02,010
+يعني على افتراض أن الـ capital D هي المصاب والـ
+
+327
+00:31:02,010 --> 00:31:07,230
+small D هي الـ normal اللي مش مصاب، على أساس أن
+
+328
+00:31:07,230 --> 00:31:12,550
+الـ disease gene الـ capital D هو الـ dominant ومرة
+
+329
+00:31:12,550 --> 00:31:17,180
+أخرى بحكي إنه هو autosomal يعني ما راح يكون
+
+330
+00:31:17,180 --> 00:31:20,980
+فيه فرق بين ولاد وبنات أو بين ذكور وإناث بالنسبة
+
+331
+00:31:20,980 --> 00:31:26,180
+للـ disease هذا، فهذه ناحية مهمة وإذا الواحد بيشوف
+
+332
+00:31:26,180 --> 00:31:36,000
+حالات مثل هذه بيلاقي الواحد أنه النقطة الأساسية
+
+333
+00:31:36,000 --> 00:31:43,990
+اللي بنصف فيها الـ autosomal dominant إنه فيه ذكور
+
+334
+00:31:43,990 --> 00:31:48,830
+وفيه إناث مصابين، وفيه ذكور وفيه إناث مش مصابين
+
+335
+00:31:48,830 --> 00:31:54,830
+يعني ما فيش اختيار لجنس معين، يعني هاي فيه أم مصابة
+
+336
+00:31:54,830 --> 00:32:00,710
+أعطت ولدان وبنت لها وبعدين ولادها وبناتها لما
+
+337
+00:32:00,710 --> 00:32:06,130
+اتزوجوا في بعضهم ما سواش مشكلة أو في بعض الأبناء
+
+338
+00:32:06,130 --> 00:32:10,530
+لآخرين ما كانش عندهم أي مشكلة بينما فيه أكثر من شخص
+
+339
+00:32:10,530 --> 00:32:17,180
+في العائلة، الملاحظة فيها، اللي هي قضية إنه ما فيش
+
+340
+00:32:17,180 --> 00:32:24,900
+skip generation يعني ما فيش إنه فيه جيل مصاب وجيل
+
+341
+00:32:24,900 --> 00:32:29,040
+مش مصاب، جيل مصاب وجيل مش مصاب، يعني قضية إنه ما
+
+342
+00:32:29,040 --> 00:32:35,900
+يعني لما أخذنا بالـ بالـ autosomal recessive بتلاقي
+
+343
+00:32:35,900 --> 00:32:40,440
+إنه مثلاً ما عندهاش ولا شخص مصاب أبداً وبيطلع في
+
+344
+00:32:40,440 --> 00:32:45,720
+عندهم شخص مصاب، السبب بيكون إنه اثنين carriers والـ
+
+345
+00:32:45,720 --> 00:32:50,920
+carrier ما بيظهر عليه شيء فبالتالي بيبين في المصاب
+
+346
+00:32:50,920 --> 00:32:53,600
+لما يكون الـ autosomal الـ dominant بدي يكون صورته
+
+347
+00:32:53,600 --> 00:33:06,820
+زي هي، أحياناً يعني إذا بالذات في يعني هنا الشخصين
+
+348
+00:33:06,820 --> 00:33:13,920
+مصابين بحالة معينة، ولسبب ما اتزوجوا، ماشي، هنا بديهم
+
+349
+00:33:13,920 --> 00:33:18,660
+يكونوا capital D، small D لأنه فيه بنت هنا مش
+
+350
+00:33:18,660 --> 00:33:24,440
+مصابة والإصابة شديدة لحظة إنه شخص من المصابين
+
+351
+00:33:24,440 --> 00:33:30,520
+توفى، وهذه مثلاً في حالة معينة وأحياناً
+
+352
+00:33:32,980 --> 00:33:41,960
+بالنسبة لإنه يكون الطفرة تبدأ في شخص معين، ماشي، فيه
+
+353
+00:33:41,960 --> 00:33:46,680
+مثلاً الـ fibroblast growth factor receptor 3 بيصير
+
+354
+00:33:46,680 --> 00:33:52,200
+فيه أرجنين في الـ position هذا اللي هو 248 على
+
+355
+00:33:52,200 --> 00:33:58,690
+بروتين معين اللي هو مستقبل الـ fibroblast growth
+
+356
+00:33:58,690 --> 00:34:04,870
+factor بتحول لـ 16 وبالتالي بتخرج وظيفته، بيصير عندي
+
+357
+00:34:04,870 --> 00:34:11,490
+mutation، في حالة زي هذه فدولة أمثلة على
+
+358
+00:34:11,490 --> 00:34:18,570
+الـ autosomal dominant inheritance
+
+359
+00:34:19,040 --> 00:34:22,980
+فهنا المثال اللي حاطينه عليه adult-onset
+
+360
+00:34:22,980 --> 00:34:27,540
+progressive sensorineural deafness inherited as
+
+361
+00:34:27,540 --> 00:34:29,440
+an autosomal dominant trait
+
+362
+00:34:32,870 --> 00:34:37,970
+فهذه الحالة الأولى حاطينها إنه درسوا عائلة معينة
+
+363
+00:34:37,970 --> 00:34:44,390
+فيه بيصير عندهم deafness بسبب، يعني مش خلل توصيلي
+
+364
+00:34:44,390 --> 00:34:49,610
+بالسمع، إنما خلل عصبي، من عصب السمع اللي فيه مشكلة
+
+365
+00:34:49,610 --> 00:34:58,330
+الثانية حالة achondroplasia راح نقول عنها والثالثة،
+
+366
+00:34:58,330 --> 00:35:01,650
+شو اسمه؟ يعني
+
+367
+00:35:03,380 --> 00:35:08,680
+thanatophoric dwarfism، نوعية معينة جينية lethal
+
+368
+00:35:08,680 --> 00:35:15,220
+in the proband كانت فيه إصابة شديدة بحيث أنه كانت
+
+369
+00:35:15,220 --> 00:35:19,140
+مع أنه لو حطوا أنه lethal كان المفروض يحطوا
+
+370
+00:35:19,140 --> 00:35:24,900
+الإشارة هذه، يعني هنا الـ proband مش معطين الكلام
+
+371
+00:35:24,900 --> 00:35:30,300
+شويه مختلف عن التفسير، يعني الـ proband اللي
+
+372
+00:35:30,300 --> 00:35:34,530
+بيحطوا عليه السهم هذا اللي هي الحالة اللي خلتّم
+
+373
+00:35:34,530 --> 00:35:40,550
+يدرسوا الموضوع، ولما يحطوا بهذا الشكل على دائرة أو
+
+374
+00:35:40,550 --> 00:35:45,850
+على مربع معناته هذا إنسان توفى فهذولا بـ degrees
+
+375
+00:35:45,850 --> 00:35:52,770
+لأشياء autosomal dominant high mal-limited
+
+376
+00:35:52,770 --> 00:35:58,630
+precocious puberty، الـ X-limited autosomal dominant
+
+377
+00:35:58,630 --> 00:36:03,750
+disorder يعني هي مثال على زي حكاية الصلع اللي
+
+378
+00:36:03,750 --> 00:36:15,490
+حكيتها قبل شوية، بقضية إن الـ pedigree يعني بتكون
+
+379
+00:36:15,490 --> 00:36:21,970
+صحيح هو يعني autosomal dominant بالنسبة لـ… يعني
+
+380
+00:36:21,970 --> 00:36:26,650
+هو الجين اللي فيه المشكلة من الـ autosomal
+
+381
+00:36:26,650 --> 00:36:30,910
+جين أو الـ autosomal chromosome، autosomal
+
+382
+00:36:30,910 --> 00:36:31,010
+chromosome، autosomal chromosome، autosomal
+
+383
+00:36:31,010 --> 00:36:33,490
+chromosome، autosomal chromosome، autosomal
+
+384
+00:36:33,490 --> 00:36:37,730
+chromosome، autosomal
+
+385
+00:36:37,730 --> 00:36:42,890
+chromosome، autosomal chromosome،
+
+386
+00:36:51,420 --> 00:36:55,600
+ليش ليس X-linked recessive بعدها؟  هل يقدر
+
+387
+00:36:55,600 --> 00:36:58,840
+يفسر لي؟
+
+388
+00:36:58,840 --> 00:37:05,320
+في حدا منتبه على شو اللي … شو اللي عم بيصير هنا في
+
+389
+00:37:05,320 --> 00:37:10,140
+هذه العائلة؟
+
+390
+00:37:10,140 --> 00:37:14,720
+الآن
+
+391
+00:37:14,720 --> 00:37:17,220
+الـ X-linked recessive
+
+392
+00:37:19,600 --> 00:37:26,420
+بكون القضية إنه male-to-male transmission ما
+
+393
+00:37:26,420 --> 00:37:33,460
+بتصير، يعني الـ X-linked recessive، إيه، الجواب كان
+
+394
+00:37:33,460 --> 00:37:38,900
+من دكتورة نادية بتقول إنه انتقل المرض من ذكر لذكر؟
+
+395
+00:37:38,900 --> 00:37:43,840
+آه، صحيح، يعني إحنا في العائلة اللي بيكون فيها X
+
+396
+00:37:43,840 --> 00:37:48,740
+-linked recessive، قضية اللي هي بيكون المصاب هو
+
+397
+00:37:48,740 --> 00:37:54,820
+الطفل أو الولد، الذكر المصاب وبتروح، بتدور، تسأل عن
+
+398
+00:37:54,820 --> 00:37:59,020
+أخواله وبتلاقي في حد فيهم مصابة، والسبب إن
+
+399
+00:37:59,020 --> 00:38:05,420
+الـfemales بيكونوا carriers بينما هنا في ملاحظة
+
+400
+0
+
+445
+00:42:33,170 --> 00:42:37,090
+اترزاجس يعني اترزاجس يعني اترزاجس يعني اترزاجس
+
+446
+00:42:37,090 --> 00:42:37,730
+يعني اترزاجس يعني اترزاجس يعني اترزاجس يعني
+
+447
+00:42:37,730 --> 00:42:37,750
+اترزاجس يعني اترزاجس يعني اترزاجس يعني اترزاجس
+
+448
+00:42:37,750 --> 00:42:48,770
+يعني اترزاجس يعني اترزاجس يعني اترزاجس يعني ا
+
+449
+00:42:48,930 --> 00:42:55,670
+هل هو Unaffected أو Affected؟ وبكون الـ H بيكون
+
+450
+00:42:55,670 --> 00:43:02,270
+Normal، والـ h بيكون مصاب،  الـ Females فيه أكثر
+
+451
+00:43:02,270 --> 00:43:09,190
+من احتمال،  قضية الاحتمال الأول Homozygous
+
+452
+00:43:09,190 --> 00:43:17,570
+Unaffected، اللي هي الأنثى الطبيعية، الـ 2 copies
+
+453
+00:43:17,570 --> 00:43:23,170
+of X-chromosomes عليهم كابيتال لتر، Unaffected gene
+
+454
+00:43:23,170 --> 00:43:30,290
+أو الـ Allele is not affected، الـ Heterozygous فيه
+
+455
+00:43:30,290 --> 00:43:34,790
+برضه Two X-chromosomes، فيه كابيتال H و Small h
+
+456
+00:43:34,790 --> 00:43:42,240
+فهذه Carrier، ماشي؛ carrier may not أو may or may not
+
+457
+00:43:42,240 --> 00:43:49,940
+be affected، الأصل إذا X-linked recessive، ماشي؛ X
+
+458
+00:43:49,940 --> 00:43:53,360
+-linked recessive، فهتكون carrier، بمعنى not
+
+459
+00:43:53,360 --> 00:43:58,220
+affected، بس إذا راح نحكي ممكن يكون X-linked
+
+460
+00:43:58,220 --> 00:44:01,440
+dominant.
+
+461
+00:44:01,440 --> 00:44:07,040
+ممكن يكون هذا احتمال، وحكينا عن احتمال ثالث اللي هو
+
+462
+00:44:07,450 --> 00:44:11,670
+في قضية الـ Ionization أو القضية الـ Inactivation
+
+463
+00:44:11,670 --> 00:44:16,030
+of the X-Chromosomes، إنه أحيانًا بشكل عشوائي، يا
+
+464
+00:44:16,030 --> 00:44:19,710
+هاي الـ Copy يا هاي الـ Copy بتكون Inactive وما
+
+465
+00:44:19,710 --> 00:44:23,790
+بتشتغلش، ففي الحالة هذه راح يكون إذا الـ Active
+
+466
+00:44:23,790 --> 00:44:28,470
+Form والـ Small h راح يكون عندها إصابة، which can
+
+467
+00:44:28,470 --> 00:44:32,450
+be affected، الـ Homozygous أو الـ Compound
+
+468
+00:44:32,450 --> 00:44:37,960
+Heterozygous، أحيانًا الـ homozygous اللي هو إنه
+
+469
+00:44:37,960 --> 00:44:45,280
+بيكون إنسان Affected، الـ capital H و h، فهي
+
+470
+00:44:45,280 --> 00:44:51,240
+بدنا نسميها homozygous مثلًا،
+
+471
+00:44:51,240 --> 00:44:58,860
+بلاقي أنا عندي جين بعطي بروتين حوالي مثلًا ألف
+
+472
+00:44:58,860 --> 00:45:06,410
+amino acid، نفترض أحيانًا فيه كثير من الأمراض زي
+
+473
+00:45:06,410 --> 00:45:11,130
+الـ Familial Mediterranean Fever أو الـ Cystic
+
+474
+00:45:11,130 --> 00:45:18,070
+Fibrosis أو كذا، الجين كبير فأحيانًا
+
+475
+00:45:18,070 --> 00:45:24,270
+النسخة الأولى مضروبة مثلًا في الـ Amino Acid رقم
+
+476
+00:45:24,270 --> 00:45:31,550
+100، والثانية مضروبة بس في محل ثاني، فلما نكون زي
+
+477
+00:45:31,550 --> 00:45:36,190
+هيك أنا بسميه compound heterozygous، لأن الـ
+
+478
+00:45:36,190 --> 00:45:43,110
+mutation مش متشابهة، يعني مش Small h Small h تماماً،
+
+479
+00:45:43,110 --> 00:45:48,510
+لأ، عبارة عن إصابتين بس لما يكونوا في مكانين مختلفين،
+
+480
+00:45:48,510 --> 00:45:53,630
+بس كل نسخة مصابة، يعني مش يعني مش نسخة مصابة في
+
+481
+00:45:53,630 --> 00:45:59,160
+مكانين، أحيانًا هي ممكنة، يعني الـ FMF، Familial الـ
+
+482
+00:45:59,160 --> 00:46:03,920
+Mediterranean fever، "حمى البحر الأبيض المتوسط"، الـ
+
+483
+00:46:03,920 --> 00:46:07,760
+Pyrin اللي هو البروتين اللي بيصير عليه الإشكالية،
+
+484
+00:46:07,760 --> 00:46:15,260
+تقريبًا ألف أمينو أسيد، وفي حوالي اثنا عشر بيسموه الـ
+
+485
+00:46:15,260 --> 00:46:19,920
+Egg Zones،  دول قطع اللي لازم يشبكوا بعضها، ففي الـ
+
+486
+00:46:19,920 --> 00:46:24,440
+Egg Zone رقم 2 والـ Egg Zone رقم 10 بيكون عليهم
+
+487
+00:46:24,440 --> 00:46:33,260
+الضربات، فإذا عندي اثنين مقاطع، كل واحدة مضروبة
+
+488
+00:46:33,260 --> 00:46:39,280
+بجهة ثانية مختلفة، راح يسبب لي مرض قريب من أن يكون
+
+489
+00:46:39,280 --> 00:46:47,000
+الـ homozygous كامل، يعني اللي هو زي الـ small h
+
+490
+00:46:47,000 --> 00:46:53,020
+small h، إذا كان كامل، أو إذا في ممكن من شيء بنقوله
+
+491
+00:46:53,020 --> 00:46:58,440
+compound heterozygous، إن الـ two copies كل
+
+492
+00:46:58,440 --> 00:47:03,620
+واحدة مضروبة في محل مختلف، واضحة فيها سلة.
+
+493
+00:47:06,800 --> 00:47:13,580
+الـ High، يعني النقطة الأساسية بالنسبة للـ X-linked
+
+494
+00:47:13,580 --> 00:47:18,080
+disease، قضية الواحد يتذكر إن الـ Male ما عندهوش
+
+495
+00:47:18,080 --> 00:47:22,160
+غير نسخة واحدة، وبالتالي هو يجب أن نسميه
+
+496
+00:47:22,160 --> 00:47:27,640
+Hemizygous، الـ Females عندهم Two copies، فبتلاقي
+
+497
+00:47:27,640 --> 00:47:31,280
+Hemizygous Normal أو Heterozygous إذا One copy
+
+498
+00:47:31,280 --> 00:47:35,530
+affected، أو Hemizygous affected إذا كان، أو
+
+499
+00:47:35,530 --> 00:47:45,690
+Compound Heterozygous، تذكروا قضية مثلًا Female إذا
+
+500
+00:47:45,690 --> 00:47:50,630
+كانت Turner Syndrome XO Inheritance، يعني One Copy
+
+501
+00:47:50,630 --> 00:47:56,170
+Only، مافيش عندها Y ولا X تانية، تعتبرها Hemizygous،
+
+502
+00:47:56,170 --> 00:48:00,650
+وبتصير قريبة من الـ Male، يعني لو أجت Female وحاملة
+
+503
+00:48:00,650 --> 00:48:09,610
+موروث لإشي معين، ممكن يظهر عليها مشكلة وتكون شكلها
+
+504
+00:48:09,610 --> 00:48:13,980
+زي المصابة، فيها سؤال؟ في سؤال، يا دكتور، من
+
+505
+00:48:13,980 --> 00:48:18,140
+Karim بيسأل عن الـ… اللي هو الـ…
+
+506
+00:48:18,140 --> 00:48:20,700
+الـ heterozygous، compound heterozygous اللي
+
+507
+00:48:20,700 --> 00:48:24,580
+بتكون انضربت في مكانين مختلفين، بيقول إيش الفرق
+
+508
+00:48:24,580 --> 00:48:27,260
+بينه وبين اللي بتكون في نفس المكان، على الـ gene،
+
+509
+00:48:27,260 --> 00:48:31,020
+يعني؟ إيش اللي… لأ، لأ، لأ، اسمع علي، اسمع علي،
+
+510
+00:48:31,020 --> 00:48:39,180
+لما نكون الجين المسؤول عن المرض كبير، ماشي، الآن
+
+511
+00:48:39,180 --> 00:48:49,340
+أنا عندي حالة، ممكن إنسان يكون جين كامل طبيعي، والجين
+
+512
+00:48:49,340 --> 00:48:55,720
+الثاني مصاب في مكانين، هذا يعني بدنا نسميه إن فيه
+
+513
+00:48:55,720 --> 00:49:04,240
+أكثر من إصابة، بيكون heterozygous، بيكون يعني إذا
+
+514
+00:49:04,240 --> 00:49:08,440
+كان X-linked recessive، فعلى الأقل عنده نسخة كاملة
+
+515
+00:49:08,440 --> 00:49:14,260
+طبيعية كويسة، وبالتالي مافيش مرض، أحيانًا بلاقي لما
+
+516
+00:49:14,260 --> 00:49:21,000
+يكون عندي أنواع متعددة من الضربات، إذا النسخة
+
+517
+00:49:21,000 --> 00:49:25,700
+الأولى مضروبة في مكان، فهي أضعف، مش طبيعية، والثانية
+
+518
+00:49:25,700 --> 00:49:31,560
+مضروبة في محل ثاني، فاللي راح يصير إنه هذا الإنسان
+
+519
+00:49:31,560 --> 00:49:37,720
+قريب من الـ homozygous، مصاب، affected، السبب إنه عنده
+
+520
+00:49:37,720 --> 00:49:43,070
+compound heterozygous، يعني هو heterozygous لأنه ما
+
+521
+00:49:43,070 --> 00:49:51,050
+كانوا زي بعض، يعني هنا إذا بدي أرسم لها مثال فأنا
+
+522
+00:49:51,050 --> 00:49:57,690
+هنا مثلًا H capital H small، وخلّيني أسميها H one وH
+
+523
+00:49:57,690 --> 00:50:07,580
+two small على small، فهنا بلاقي X H small one وXH2
+
+524
+00:50:07,580 --> 00:50:14,320
+يعني واحدة مضروبة في محل، فهي مضروبة، يعني مسببة
+
+525
+00:50:14,320 --> 00:50:19,220
+لمشكلة أو عاملة مشكلة ومرض، والثاني كمان نفس الشيء،
+
+526
+00:50:19,220 --> 00:50:25,600
+يعني بالمحصلة هو قريب من homozygous، ماشي، يعني فهو
+
+527
+00:50:25,600 --> 00:50:29,400
+affected، في الحالة هذه أنا بدي أسميه compound
+
+528
+00:50:29,400 --> 00:50:36,130
+heterozygous، compound لأنه أكثر من مكان في نفس الجين،
+
+529
+00:50:36,130 --> 00:50:42,210
+بس مكانين مختلفين، مختلفين مش في نفس المحل يعني،
+
+530
+00:50:42,210 --> 00:50:50,160
+ممكن هذا يأثر بطريقة ما على شدة المرض،
+
+531
+00:50:50,160 --> 00:50:55,120
+ما يعطينا الشكل للـ Phenotype النهائي، يعني إذا
+
+532
+00:50:55,120 --> 00:50:58,200
+الإصابة في المكان رقم 100 غير الإصابة في المكان
+
+533
+00:50:58,200 --> 00:51:04,890
+رقم 600 بتعطيك شكل مختلف من المرض، يعني، سنأخذ
+
+534
+00:51:04,890 --> 00:51:08,750
+مثلًا الـ Hemoglobinopathies، في الـ S-Hemoglobin
+
+535
+00:51:08,750 --> 00:51:12,390
+اللي فيه تبع الـ Sickle Cell اللي في محل معين، وفي الـ
+
+536
+00:51:12,390 --> 00:51:17,310
+C-Hemoglobin اللي بيكون خلل ثاني في محل ثاني، ففيه
+
+537
+00:51:17,310 --> 00:51:22,190
+بيطلع لي حد عنده بيسموه SC-Hemoglobin، هذا بيكون
+
+538
+00:51:22,190 --> 00:51:26,710
+نسخة مصابة بالمحل الـ S ونسخة مصابة بالمحل الـ C،
+
+539
+00:51:26,710 --> 00:51:31,660
+فهذا بنسميه compound heterozygous، يعني في إصابتين،
+
+540
+00:51:31,660 --> 00:51:37,600
+بس في محلين مختلفين في نفس الجين، فهو ما أقدرش أقول
+
+541
+00:51:37,600 --> 00:51:43,320
+عنه homozygous لأنه مش متشابهات، ماشي، إن شاء الله
+
+542
+00:51:43,320 --> 00:51:49,840
+وضحنا القضية الآن.
+
+543
+00:51:49,840 --> 00:51:56,820
+هنا يعني حاطين أمثلة على الـ Duchenne muscular
+
+544
+00:51:56,820 --> 00:52:03,920
+dystrophy، الـ Duchenne اللي هو من أمثلة الأمراض الـ
+
+545
+00:52:03,920 --> 00:52:09,040
+X-linked recessive، ماشي، فإذا الـ males هما اللي
+
+546
+00:52:09,040 --> 00:52:14,540
+affected، الـ females هما الـ carriers، وقاعدين أنا
+
+547
+00:52:14,540 --> 00:52:22,400
+أدرس اللي هو يعني الـ expression تبع الـ gene، يعني
+
+548
+00:52:22,400 --> 00:52:27,340
+الـ gene المضروب هذا بالأخير مسؤول عن بروتين معين،
+
+549
+00:52:28,030 --> 00:52:33,670
+ولما أستخدم الـ Fluorescence Microscopy وأتطلع
+
+550
+00:52:33,670 --> 00:52:39,610
+على الـ Dystrophin Distribution والـ Debris، سأجد
+
+551
+00:52:39,610 --> 00:52:47,410
+مثلًا الإنسان الطبيعي اللي هو الـ A، الولد
+
+552
+00:52:47,410 --> 00:52:53,790
+المصاب، سأجده مثلًا الـ B، والـ يعني هنا الـ
+
+553
+00:52:53,790 --> 00:52:57,330
+Protein اللازم أو اللي كان مسؤول عنه المفروض يكون
+
+554
+00:52:57,330 --> 00:53:02,430
+موجود حتى تكون عضلاته طبيعية، مختفي تماماً، والـ C
+
+555
+00:53:02,430 --> 00:53:09,890
+Female Carrier، حاملة الموروث، وبنلاحظ هنا يعني صحيح
+
+556
+00:53:09,890 --> 00:53:16,740
+مظهرياً، أحنا حكينا إن هذا عبارة عن متنحي، والأصل إذا
+
+557
+00:53:16,740 --> 00:53:21,120
+عندك نسخة واحدة تكون كافية، بس بطريقة الدراسة هذه
+
+558
+00:53:21,120 --> 00:53:27,920
+ملاحظين إنه فيه ضعف، بس مش بدرجة شدة الـ Affected
+
+559
+00:53:27,920 --> 00:53:35,940
+Male، ويعني مش واضح إنه فيه Disease وفيه مرض، فهنا
+
+560
+00:53:36,410 --> 00:53:40,770
+يعني هذا مثال على الـ X-linked recessive اللي هو
+
+561
+00:53:40,770 --> 00:53:44,550
+الـ muscular dystrophy، muscular dystrophy، muscular
+
+562
+00:53:44,550 --> 00:53:45,250
+dystrophy، muscular dystrophy، muscular dystrophy،
+
+563
+00:53:45,250 --> 00:53:45,570
+muscular dystrophy، muscular dystrophy، muscular
+
+564
+00:53:45,570 --> 00:53:46,930
+dystrophy، muscular dystrophy، muscular dystrophy،
+
+565
+00:53:46,930 --> 00:53:49,550
+muscular dystrophy، muscular dystrophy، muscular
+
+566
+00:53:49,550 --> 00:53:52,350
+dystrophy، muscular dystrophy، muscular dystrophy،
+
+567
+00:53:52,350 --> 00:54:00,870
+muscular dystrophy، muscular
+
+568
+00:54:00,870 --> 00:54:07,800
+dystrophy، يعني البحث هنا على مستوى البروتين
+
+569
+00:54:07,800 --> 00:54:13,580
+المطلوب تكوينه من الجين تبع الـ Duchenne Muscular
+
+570
+00:54:13,580 --> 00:54:21,180
+Dystrophy، كنوع شديد من  الضعف العضلي، الـ Duchenne
+
+571
+00:54:21,180 --> 00:54:26,780
+راح تأخذوا بعدين يعني من الأمثلة على، يعني أمراض
+
+572
+00:54:26,780 --> 00:54:33,880
+العضلات الشديدة، بتبدأ في عمر صغير، الطفل المولود
+
+573
+00:54:33,880 --> 00:54:38,900
+الجديد، ما بيقدرش يقعد في وقته، ما بيقدرش يوقف، ما بيقدرش
+
+574
+00:54:38,900 --> 00:54:43,060
+يمشي متأخر لما يمشي، ما بيقدرش يقلب، لما كذا، اللي هي
+
+575
+00:54:43,060 --> 00:54:48,780
+الـ Milestones أو الأحداث الرئيسية اللي لازم تحدث
+
+576
+00:54:48,780 --> 00:54:54,480
+في النمو العضلي للإنسان في فترة معينة، يعني، الـ Duchenne
+
+577
+00:54:54,480 --> 00:54:59,840
+muscular dystrophy هو X-linked recessive، وحتى
+
+578
+00:54:59,840 --> 00:55:04,800
+الـ females، سواء لو أحد منهم يريد أن يأخذها
+
+579
+00:55:04,800 --> 00:55:10,080
+كـ Lyonization، اللي يعني إنه صار Inactive Form في
+
+580
+00:55:10,080 --> 00:55:15,390
+بعض الخلايا، و active في خلايا ثانية، أو إنه one copy
+
+581
+00:55:15,390 --> 00:55:20,690
+alone is not enough to produce normal amount of
+
+582
+00:55:20,690 --> 00:55:25,430
+dystrophin needed for normal muscular activity، للـ
+
+583
+00:55:25,430 --> 00:55:30,650
+activity تبع العضلات بالنسبة للإنسان، فهذا مثال على
+
+584
+00:55:30,650 --> 00:55:38,350
+X-linked recessive، في أسئلة؟ الـ
+
+585
+00:55:38,350 --> 00:55:46,310
+X-linked recessive، جدولهم بهذا الشكل، إذا
+
+586
+00:55:46,310 --> 00:55:55,610
+أتت فتاة Normal، في الحالة هذه X capital، XH capital،
+
+587
+00:55:55,610 --> 00:56:04,330
+XH capital، تتزوج إنسان مصاب، Male which
+
+588
+00:56:04,330 --> 00:56:08,230
+has been affected، فرح يكون عنده Y-chromosome،
+
+589
+00:56:08,230 --> 00:56:17,760
+Male، وعنده الـ h صغير، فإذا كانت الفتاة عامة،
+
+590
+00:56:17,760 --> 00:56:25,060
+أو عامة تمامًا، فهي تتعامل مع شخص مصاب، أو غير عام،
+
+591
+00:56:25,060 --> 00:56:30,360
+فاللي راح يصير إن كل البنات راح يصيروا Carriers،
+
+592
+00:56:30,360 --> 00:56:35,760
+سبب أنه أخذوا من أبوهم الـ h الصغير، وكل الـ Males
+
+593
+00:56:35,760 --> 00:56:42,060
+عادي أو غير عادي، لأنهم بيأخذوا من أبوهم الـ Y، فهذا
+
+594
+00:56:42,060 --> 00:56:47,720
+زواج Normal Female مع Affected Male، أثناء
+
+595
+00:56:47,720 --> 00:56:52,220
+الاختلاف، لو نأخذ إنه Normal Male بهذا الشكل،
+
+596
+00:56:52,220 --> 00:57:03,820
+Capital X Capital H، ثاني Y، اتزوج من Carrier Female،
+
+597
+00:57:03,820 --> 00:57:13,240
+Capital H Small h، الـ Genotype تبعتها، اللي راح يصير،
+
+598
+00:57:13,240 --> 00:57:23,380
+أنه لهذه العائلة بالنسبة لـ Males، ماشي، الربع،
+
+599
+00:57:23,380 --> 00:57:29,540
+يعني الربع للـ Offspring اللي بالنسبة لـ Males،
+
+600
+00:57:29,540 --> 00:57:36,040
+راح يكونوا Normal، وراح يكون الربع الثاني affected،
+
+601
+00:57:36,040 --> 00:57:42,100
+ماشي، يعني إذا امرأة Carrier اتزوجت إنسان طبيعي،
+
+602
+00:57:42,100 --> 00:57:49,000
+للولاد، الاحتمالية نص أن يكون affected أو normal،
+
+603
+00:57:49,000 --> 00:57:58,980
+وبالنسبة للـ Females، منّهم، فيه احتمالية ربع،
+
+604
+00:57:58,980 --> 00:58:06,280
+normal، non-carrier، يعني حطينا normal هون، لأنه راح
+
+605
+00:58:06,280 --> 00:58:16,640
+يكون HH، HH، HH، HH، HH، HH، HH، HH، HH،
+
+606
+00:58:16,640 --> 00:58:17,460
+HH، HH، HH، HH، HH، HH، HH، HH، HH، HH،
+
+607
+00:58:17,460 --> 00:58:17,480
+HH، HH، HH، HH، HH، HH، HH، HH، HH، HH،
+
+608
+00:58:17,480 --> 00:58:33,400
+HH، HH، HH، HH، HH،
+
+609
+00:58:33,530 --> 00:58:40,090
+نصّهم Carrier، ونصّهم طبيعيات، فبيكون هيك النسب، هي
+
+610
+00:58:40,090 --> 00:58:44,990
+قضية دي الواحد ينتبه لها، وينكرها، هو أنا بـ
+
+611
+00:58:44,990 --> 00:58:48,970
+degree للـ X-linked recessive disorder، في حالة
+
+612
+00:58:48,970 --> 00:58:52,350
+الهيموفيليا A، وتجيبنا صورة عنها، يعني هو أنا
+
+613
+00:58:52,350 --> 00:58:57,050
+الملاحظ في الغالب الـ B degree مثلًا زي هذا
+
+614
+00:58:57,050 --> 00:59:04,540
+الإنسان، هذا ولد، ماشي، مربع، وبتلاقيه مصاب، بتيجي تأخذ
+
+615
+00:59:04,540 --> 00:59:12,460
+تاريخ عائلي منه، بتلاقي خاله مصاب، ماشي، والإنسان هذا
+
+616
+00:59:12,460 --> 00:59:19,300
+اللي هي أمه، بتأخذ منها تاريخ مرضي كمان، بتطلع خاله
+
+617
+00:59:19,300 --> 00:59:31,550
+
+667
+01:04:35,400 --> 01:04:38,880
+dominant
+
+668
+01:04:39,440 --> 01:04:45,780
+Inheritance هذه بما أن في كل الأجيال في ناس مصابين
+
+669
+01:04:45,780 --> 01:04:58,240
+إنه Dominant Pattern، بس الحالة هذه ماشية يعني إذا
+
+670
+01:04:58,240 --> 01:05:06,300
+بلاحظ شغل ثانية، أو بلاحظ ناحية معينة، إنه لما يكون
+
+671
+01:05:06,300 --> 01:05:14,710
+المصاب ذكر، ماشيكل ولاده طبيعيين، وكل بناته مصابة
+
+672
+01:05:14,710 --> 01:05:23,870
+يعني هذا كمان ذكر ثاني مصاب، كل ولاده طبيعيين بيض،
+
+673
+01:05:23,870 --> 01:05:30,890
+والبنات مصابة، الـFemale مثلاً، لما ناخد مثل هذه
+
+674
+01:05:30,890 --> 01:05:39,990
+المصابة، أعطت ولاد وبنات مصابين، فهذه الـInheritance
+
+675
+01:05:39,990 --> 01:05:45,330
+تبع الـX-Linked Dominant Inheritance، واللي
+
+676
+01:05:45,330 --> 01:05:51,710
+بيحكوا عنه هنا، قضية ثانية، إن أحيانًا لما يكون
+
+677
+01:05:51,710 --> 01:05:55,670
+الإصابة
+
+678
+01:05:55,670 --> 01:06:01,350
+بالنسبة للـMales، لأن في نسخة واحدة شديدة كثير أحيانًا
+
+679
+01:06:01,350 --> 01:06:07,510
+يعني بيسموه Lethal Gene، يعني سواء إن هذا في الـ
+
+680
+01:06:07,510 --> 01:06:12,230
+Autosomal أو في الـX-link، إذا كان إنه لما يكون
+
+681
+01:06:12,230 --> 01:06:18,310
+عندي Two copies، في حالة الـAutosomal recessive، أو
+
+682
+01:06:18,310 --> 01:06:22,090
+في حالة الـX-linked recessive في الـMales، إذا One
+
+683
+01:06:22,090 --> 01:06:27,650
+copy، يعني الواحد ماعندهوش أي جين طبيعي تماماً
+
+684
+01:06:28,100 --> 01:06:32,440
+أحيانًا حتى في الـEmbryonic Period، أو في مرحلة
+
+685
+01:06:32,440 --> 01:06:37,840
+معينة، ممكن ينتج عنه أنه يكون Lethal، فلما يكون
+
+686
+01:06:37,840 --> 01:06:42,520
+Lethal الـGene، بيغير الـPercentages، الـPossible
+
+687
+01:06:42,520 --> 01:06:51,150
+تطلع اللي أحنا بنشوفها، ماشي؟ فهنا هذا مثال بيكون
+
+688
+01:06:51,150 --> 01:06:55,630
+X-linked dominant
+
+689
+01:06:55,630 --> 01:07:01,450
+inheritance، بس كمان فوق هذا أنه Lethal gene، أنه
+
+690
+01:07:01,450 --> 01:07:05,410
+مافيش Males affected، هذه برضه أحيانًا بتحدث
+
+691
+01:07:05,410 --> 01:07:13,310
+موجودة، وبتكون يعني ظاهرة موجودة في أسئلة؟ في سؤال
+
+692
+01:07:13,310 --> 01:07:20,490
+دكتور من كريم بيقول: لما يكون الجنين ذكر ميت، ليش ما
+
+693
+01:07:20,490 --> 01:07:25,210
+بينذكر في شجرة العائلة؟ مش في رمز للجنين الذكر، أو
+
+694
+01:07:25,210 --> 01:07:32,610
+الجنين الميت؟ صحيح، صحيح، إحنا هنا يعني أحيانًا
+
+695
+01:07:32,610 --> 01:07:39,610
+نحكي عن ظاهرة اللي هي في الـ.. يعني إذا أتأخر قبل
+
+696
+01:07:39,610 --> 01:07:46,380
+ما صارت الوفاة، وبيّن حملها بشكل واضح، بس إذا بتتذكر
+
+697
+01:07:46,380 --> 01:07:53,160
+حكينا إنه أحيانًا في أوائل الحمل، شهر الأول، يمكن
+
+698
+01:07:53,160 --> 01:07:57,880
+حتى ما يبينش على المرأة إن أنا حامل، يعني بتكون يا
+
+699
+01:07:57,880 --> 01:08:02,480
+دوبك اتأخرت الدورة يومين، ثلاثة، وبعدين نزلت دورة
+
+700
+01:08:02,480 --> 01:08:09,740
+شديدة، وبس يعني، فأحيانًا حسب أهمية الجين ودوره، ومش
+
+701
+01:08:09,740 --> 01:08:14,970
+بيتدخل، أحيانًا ما بيبينش، فاهم عليّ كيف؟ أما إذا
+
+702
+01:08:14,970 --> 01:08:22,750
+الأصل إنه إحنا بنعمل شجرة عائلة، لازم نيجي ونحاول
+
+703
+01:08:22,750 --> 01:08:27,610
+نحط كل المعلومات بصدق، و بحقيقة، شو اللي شفناها، و
+
+704
+01:08:27,610 --> 01:08:33,670
+بنسأل الأهل، وشو صار، وكده، فكرة اللي بيسموها الـ
+
+705
+01:08:33,670 --> 01:08:42,010
+Lethal Gene، اللي هي إنه الإصابة، سواء إذا Recessive
+
+706
+01:08:42,650 --> 01:08:47,130
+معناته لازم Two copies، حتى تصبح مصابي، أو إذا was
+
+707
+01:08:47,130 --> 01:08:51,250
+recessive للـX-linked، بدي يكون في الـMales، لأنه
+
+708
+01:08:51,250 --> 01:08:56,250
+100% الجينات مصابة، يعني في الحالتين هذولة بيسموه
+
+709
+01:08:56,250 --> 01:09:01,930
+lethal gene، ففي حالة هذه سواء ذكر ولا أنثى ما
+
+710
+01:09:01,930 --> 01:09:07,970
+بعيش، ما بتقدم، ما.. يعني إذا بيّن معاي
+
+711
+01:09:10,660 --> 01:09:16,460
+وأنا بالنسبة لـ.. يعني إذا أخدنا مثلاً الصورة هذه،
+
+712
+01:09:16,460 --> 01:09:20,420
+ماشي الفكرة،
+
+713
+01:09:20,420 --> 01:09:28,520
+هذه الأنثى مثلاً جابت بنات طبيعيات، ماشي؟ وهنا، هذه
+
+714
+01:09:28,520 --> 01:09:32,440
+مصابة زي أمها، بس فيه بنت طبيعية، لما تكون البنت
+
+715
+01:09:32,440 --> 01:09:35,240
+طبيعية، معناته أنه
+
+716
+01:09:37,610 --> 01:09:47,030
+هيستحيل هذه الظاهرة تكون X-Linked Recessive،
+
+717
+01:09:47,030 --> 01:09:54,750
+لأنه لو Recessive، ماشي، لو Recessive كانت البنات
+
+718
+01:09:54,750 --> 01:10:01,010
+كلهم راح يكونوا، لأن الـTwo Copies involved، فبكون
+
+719
+01:10:01,010 --> 01:10:05,550
+أنه تظهر واحدة طبيعية من البنات، معناته أكيد الأم
+
+720
+01:10:07,220 --> 01:10:14,580
+بدنا نسميها الـHeterozygous، يعني الـTwo Copies مختلفة
+
+721
+01:10:14,580 --> 01:10:18,620
+حتى يعطينا بهذا الشكل للـFemales، إذا على الـX
+
+722
+01:10:18,620 --> 01:10:22,520
+-Chromosome، وحتى على الـAutosomal Chromosome، لازم
+
+723
+01:10:22,520 --> 01:10:27,080
+تكون الـCopies مختلفة، لما أنا أشوف آلة بهذه الطريقة
+
+724
+01:10:27,080 --> 01:10:32,260
+أنه لأكثر من Generation، وفيه مصابين، وفيه غير
+
+725
+01:10:32,260 --> 01:10:39,600
+مصابين، يعني بهذا الشكل، معناته في إنه إذا كان
+
+726
+01:10:39,600 --> 01:10:48,020
+homozygous لهذه الـ"شخصية"، سواءً بالـMales، لما
+
+727
+01:10:48,020 --> 01:10:51,900
+تكون على الـX، وOne copy، أو إذا فيه Male، Two
+
+728
+01:10:51,900 --> 01:10:59,720
+copies، بيكونوا مصابين، بنتج عنه إنه بيكون الـ
+
+729
+01:10:59,720 --> 01:11:05,640
+بيكون فيه lethal gene، كما نسميه، إنه راح يكون يتسبب
+
+730
+01:11:05,640 --> 01:11:12,200
+بالوفاة الجنين قبل ما حتى يولد، يعني بدّي الواحد
+
+731
+01:11:12,200 --> 01:11:18,140
+ينتبه لها، فهي من العوامل اللي بتخربط، بتخربط
+
+732
+01:11:18,140 --> 01:11:23,740
+الظواهر، يعني بتخلّي النسب ما تكون زي اللي حكيناها
+
+733
+01:11:23,740 --> 01:11:28,340
+وتوقعناها حسب الـGenotype والـPhenotype تبعنا،
+
+734
+01:11:28,340 --> 01:11:28,920
+واضح؟
+
+735
+01:11:33,020 --> 01:11:39,620
+هنا نأخذ عائلة عندهم Female Epilepsy، وCognitive
+
+736
+01:11:39,620 --> 01:11:45,940
+Impairment Syndrome، يعني في عائلة النساء عندهم
+
+737
+01:11:45,940 --> 01:11:51,640
+بيصير معاهم seizures، وبيصير معاهم يعني بعض درجة
+
+738
+01:11:51,640 --> 01:11:57,220
+بسيطة من التخلف العقلي، ماشي؟ فهي X-linked dominant
+
+739
+01:11:57,220 --> 01:11:58,220
+inheritance
+
+740
+01:12:00,720 --> 01:12:06,920
+(Incomprehensible)
+
+741
+01:12:06,920 --> 01:12:07,760
+(Incomprehensible)
+
+742
+01:12:07,760 --> 01:12:07,960
+(Incomprehensible)
+
+743
+01:12:07,960 --> 01:12:15,520
+(Incomprehensible)
+
+744
+01:12:15,520 --> 01:12:25,900
+(Incomprehensible)
+
+745
+01:12:25,900 --> 01:12:31,970
+(Incomprehensible) هذه الـPedigree، العائلة، أول شيء
+
+746
+01:12:31,970 --> 01:12:38,930
+الجد بالـGeneration الأول كانت مصابة، ماشي، زوجها
+
+747
+01:12:38,930 --> 01:12:47,570
+توفى، طبيعي كان، الملاحظ، ماشي، هذه X-linked
+
+748
+01:12:47,570 --> 01:12:52,330
+dominant inheritance، الملاحظ أن الـFemales هم
+
+749
+01:12:52,330 --> 01:12:59,370
+الوحيدات الـaffected، وكل Generation، وكل generation
+
+750
+01:12:59,370 --> 01:13:04,470
+فيه مصابين أو مصابات، في الحالة هذه، فهذا disease
+
+751
+01:13:04,470 --> 01:13:12,050
+الـX-linked dominant inheritance، ماشي، الـmales
+
+752
+01:13:12,050 --> 01:13:20,650
+hemizygous for a premature termination، الـmales
+
+753
+01:13:20,650 --> 01:13:32,080
+بياخدوا من الأم One copy،  والأم يعني لازم تكون heterozygous،
+
+754
+01:13:32,080 --> 01:13:38,440
+X-linked dominant، فالأم في الحالة هذه مستحيل تكون
+
+755
+01:13:38,440 --> 01:13:44,080
+homozygous، للـTwo copies، تكون مصابات، لأنه فيه من
+
+756
+01:13:44,080 --> 01:13:50,800
+بناتها فيه مصابات، وفيه طبيعيات، ماشي؟ فيه مصابات
+
+757
+01:13:50,800 --> 01:13:51,800
+وفيه طبيعيات
+
+758
+01:13:54,290 --> 01:14:00,370
+فهذه ممكنة، وهذه تحدث، ويجب أن يكون الواحد ينتبه لها،
+
+759
+01:14:00,370 --> 01:14:03,910
+ويدرسها
+
+760
+01:14:03,910 --> 01:14:10,250
+الموضوع، هذه الفكرة مرة ثالثة أو رابعة أو خامسة،
+
+761
+01:14:10,250 --> 01:14:16,690
+لما تشوف كل جيل فيه إصابات، هذا واضح، ماشي؟ مافيش
+
+762
+01:14:16,690 --> 01:14:21,140
+skip generation، هذه ناحية، الناحية الثانية، واضح
+
+763
+01:14:21,140 --> 01:14:23,900
+هنا إن الـFemales هم اللي affected، والـMales
+
+764
+01:14:23,900 --> 01:14:29,880
+normal، يعني هنا Normal Male، وهنا Carrier Male
+
+765
+01:14:29,880 --> 01:14:40,300
+تعتبروه، أو Hemizygous، للـMales، مش مؤثر عليه، فيعني
+
+766
+01:14:40,300 --> 01:14:46,680
+هذه X-linked dominant، في
+
+767
+01:14:46,680 --> 01:14:57,020
+الحالة هذه، بـDegree Showing Dyschondrosis، أو
+
+768
+01:14:57,020 --> 01:15:03,560
+Dyschondrosteosis، هذا مرض، يعني بتوقع بيكون فيه
+
+769
+01:15:03,560 --> 01:15:09,420
+خلل بالعظام، ونمو العظام، والـCartilage أو الغضاريف
+
+770
+01:15:09,420 --> 01:15:14,940
+تبع الـDisease
+
+771
+01:15:14,940 --> 01:15:22,570
+هذا دكتور، في سؤال من كريم بيقول: شو الـGenotype
+
+772
+01:15:22,570 --> 01:15:29,950
+للمال الكارير؟ في الحالة هذه، يعني الأصل، والمال
+
+773
+01:15:29,950 --> 01:15:36,410
+السليم طبعاً كمان آه، يعني إذا بتتذكر لما حطينا
+
+774
+01:15:36,410 --> 01:15:43,190
+صورة الـDuchenne muscular dystrophy، ماشي، إذا
+
+775
+01:15:43,190 --> 01:15:47,360
+بتتذكر صورة الـDuchenne، يعني بس عشان أذكر قضية
+
+776
+01:15:47,360 --> 01:15:55,200
+معينة الآن، هذا الإنسان بشوفه طبيعي، phenotype، وهذه
+
+777
+01:15:55,200 --> 01:16:00,760
+الـFemale اللي هي الـcarrier، الأصل أني لما قاعدي
+
+778
+01:16:00,760 --> 01:16:05,520
+أنا أفحصها كـmuscle power، أو أشوفها وكذا، بلاقيها
+
+779
+01:16:05,520 --> 01:16:12,180
+طبيعية، بس أنا إذا عندي أدوات أفحص بشكل أدق على الـ
+
+780
+01:16:12,180 --> 01:16:16,360
+Gene Expression، على البروتين، على الـRNA، على كذا
+
+781
+01:16:16,360 --> 01:16:23,540
+ممكن أشوف درجات من الـPhenotype بتكون مختلفة،
+
+782
+01:16:23,540 --> 01:16:31,430
+واضح؟ فيعني هنا حاطينا كصورة، هي يعني بدل واحد، يعني
+
+783
+01:16:31,430 --> 01:16:37,950
+يدخل في الـReference تبع هذه الـStudy، تبعت هذه
+
+784
+01:16:37,950 --> 01:16:42,210
+العيلة، كيف فحصوها؟ كيف؟ شو اللي فحصوا عليه؟ وكيف
+
+785
+01:16:42,210 --> 01:16:46,650
+أثبتوا إنه هذا Carrier ومش Carrier؟ والكلام هذا،
+
+786
+01:16:46,650 --> 01:16:55,970
+فاهم عليّ كيف؟ بس يعني بشكل عام، الأصل عام
+
+787
+01:16:55,970 --> 01:17:02,970
+والأبيض كامل، والأزرق كامل مصاب، هيك بفهم اللي هي يعني بشكل عام،
+
+788
+01:17:02,970 --> 01:17:07,430
+مبدأ، فالآن يعني أنا بفهم إنه في الـSecond
+
+789
+01:17:07,430 --> 01:17:14,010
+Generation، الـTwo Males هذولة طبيعيين مظهريًا،
+
+790
+01:17:14,010 --> 01:17:20,210
+ماشي؟ بس كل واحد منهم أعطى بنته من البنات اللي
+
+791
+01:17:20,210 --> 01:17:28,470
+عنده من أمه، فبكون هو حامل شيء معين، يمكن مظهريًا أنا
+
+792
+01:17:28,470 --> 01:17:35,150
+لازم أعرف أنه يعني أنا استنتجت أنه Carrier، بس لأنه
+
+793
+01:17:35,150 --> 01:17:43,260
+نقل المرض، بس شو بالضبط بيّن عليه، بحيث أنه بأي طريقة
+
+794
+01:17:43,260 --> 01:17:48,200
+فحصناها حتى نتثبت إنه فعلاً هو Carrier، وين الـX
+
+795
+01:17:48,200 --> 01:17:52,520
+-Chromosome، وليش، مع أنه عنده نسخة واحدة، الأصل هذا
+
+796
+01:17:52,520 --> 01:18:01,200
+dominant، يعني dominant بمعنى لازم يظهر، هيك الأصل،
+
+797
+01:18:01,200 --> 01:18:05,020
+ماشي، لما نكون في عندي Two copies، One copy بتكفي
+
+798
+01:18:05,020 --> 01:18:10,500
+حتى يظهر المرض، فهذه هنا يعني بدأت تكون داخلة فيها
+
+799
+01:18:10,500 --> 01:18:17,810
+موضوع اللي حكينا عنه، قضية الأحيانًا الـX-linked
+
+800
+01:18:17,810 --> 01:18:26,690
+يعني التأثير اللي موجود، زي حكينا عن حكاية الصلع في
+
+801
+01:18:26,690 --> 01:18:32,570
+الـMales، بيكون certain gene dominant، والـFemales
+
+802
+01:18:32,570 --> 01:18:35,990
+بيصير recessive، يعني بدأت تكون صارت ظاهرة بهذا
+
+803
+01:18:35,990 --> 01:18:44,100
+الشكل، حتى الواحد يفسرها، واضح؟ بيقول يعني هو يعني
+
+804
+01:18:44,100 --> 01:18:48,260
+نفهم إنه الـ"Male" الحامل هو في الأصل يعني مصاب،
+
+805
+01:18:48,260 --> 01:18:54,620
+ولكن ما ظهرت عليه الأعراض؟ أنا حكيت يعني أحيانًا
+
+806
+01:18:54,620 --> 01:19:01,800
+لما نقول "dominant"، ولا "recessive"، ماشي؟ الكلمة
+
+807
+01:19:01,800 --> 01:19:09,140
+زي هيك، فيه كمان درجات في الاختلاف بين الـ"Male"
+
+808
+01:19:09,140 --> 01:19:18,240
+والـ"Female"، يعني ممكن ظاهرة معينة تكون dominant في
+
+809
+01:19:18,240 --> 01:19:23,480
+الـFemale، يعني قصدي One copy is enough وكذا،
+
+810
+01:19:23,480 --> 01:19:30,480
+وبالـMales تصير recessive، القصد فيها إنه بتلاقي
+
+811
+01:19:30,480 --> 01:19:35,900
+جينات ثانية، أشياء ثانية، ما خلّت المظهر الموجود،
+
+812
+01:19:35,900 --> 01:19:42,420
+واضح؟ فهي طريقة يحاولون من خلالها يفسروا
+
+813
+01:19:42,420 --> 01:19:48,580
+الـpedigrees اللي بيشوفوها، طبعاً يعني مين اتزوج
+
+814
+01:19:48,580 --> 01:19:55,180
+مين، وفعلاً مافيش أي ظواهر ثانية تتدخل في التفسير
+
+815
+01:19:55,180 --> 01:19:58,020
+يعني
+
+816
+01:19:59,130 --> 01:20:05,510
+ممكن أحيانًا تطلب تاريخ عائلة من عائلة ممتدة، ويكون
+
+817
+01:20:05,510 --> 01:20:12,070
+مثلًا واحد مايعرفش تمامًا مين عمه ولا خالته،
+
+818
+01:20:12,070 --> 01:20:17,350
+اتجوز مين وكذا، يعني ممكن يكون في بعض القصور،
+
+819
+01:20:17,350 --> 01:20:25,190
+أحيانًا يعني، فالفكرة يعني مرة أخيرة بقول: إذا بتشوف
+
+820
+01:20:25,190 --> 01:20:30,290
+الذكور والإناث زي بعض، بدّك تقول Autosomal، إذا فيه
+
+821
+01:20:30,290 --> 01:20:34,630
+فرق كبير، الأصل إذا Males بتقول X-linked recessive،
+
+822
+01:20:34,630 --> 01:20:39,790
+إذا فيه Males بدّك تقول X-linked dominant، والشغل
+
+823
+01:20:39,790 --> 01:20:45,450
+الثاني، إذا بتشوف كل الـgenerations مصابين،
+
+824
+01:20:45,450 --> 01:20:49,330
+dominant، إذا فيه skip generation، بدّي يكون فيه
+
+825
+01:20:49,330 --> 01:20:52,850
+recessive، فاهم عليّ إيه؟ فبدّك كل هذه النواحي تنتبه
+
+826
+01:20:52,850 --> 01:21:03,130
+إليها، وفيه كمان ظواهر زي الـLethal Gene، وقضية الـ
+
+827
+01:21:03,130 --> 01:21:09,950
+Penetrance، أو درجة قدرة الجين على الظهور، أحيانًا
+
+828
+01:21:09,950 --> 01:21:15,550
+فيه درجة بسيطة من الخلل، بحيث أنه أحيانًا بتعدي على
+
+829
+01:21:15,550 --> 01:21:21,140
+أنه طبيعي، فأحيانًا يعني هذه ظاهرة بتكون موجودة، يعني
+
+830
+01:21:21,140 --> 01:21:27,260
+صحيح هو dominant، بس لسبب أو لآخر من جينات أخرى،
+
+831
+01:21:27,260 --> 01:21:37,380
+المظهر ما بيّن، ماشي؟ فهنا حاطين
+
+832
+01:21:37,380 --> 01:21:42,540
+إنه ممكن يكون الـY-Chromosome فيه دخل، ويعتبر زي
+
+833
+01:21:42,540 --> 01:21:47,910
+الـPseudoautosomal، الـGene on the X and Y، فصحيح
+
+834
+01:21:47,910 --> 01:21:53,010
+يعني هو مكانه على الـX-Chromosome، بس كمان الـY
+
+835
+01:21:53,010 --> 01:21:58,370
+فيه شيء موجود، أحيانًا يعني الـX-Chromosome وY
+
+836
+01:21:58,370 --> 01:22:04,550
+-Chromosome، في بعض الجينات أحيانًا تتدخل، يعني زي
+
+837
+01:22:04,550 --> 01:22:11,590
+مثلًا وجود الشعر على صيوان الأذن، "هيريبينيا"، هذه
+
+838
+01:22:11,590 --> 01:22:18,870
+ظاهرة Y-Chromosome Controlled، يعني المسؤول عنها الـ
+
+839
+01:22:18,870 --> 01:22:25,770
+Y-Chromosome مثلاً، فأحيانًا بتلاقي عائلات أو حالات
+
+840
+01
+
+889
+01:27:13,930 --> 01:27:18,750
+اللي
+
+890
+01:27:18,750 --> 01:27:22,610
+دخل فيه إنه ممكن هذه الصفة الوراثية تنتقل أو ما
+
+891
+01:27:22,610 --> 01:27:28,080
+تنتقل، هذه ناحية مهمة، وهذه ظاهرة تحدث لما ندرس أي
+
+892
+01:27:28,080 --> 01:27:33,760
+إنسان بدقة عالية، نوعية الجينات اللي موجود عنده في
+
+893
+01:27:33,760 --> 01:27:41,800
+الخلايا، ممكن يلاقي فيه اختلافات وموزاييك
+
+894
+01:27:41,800 --> 01:27:48,440
+من الجينات، وبتكون فيه اختلافات موجودة في نسب معينة
+
+895
+01:27:48,440 --> 01:27:55,170
+من الخلايا، وبتكون إن الـMutation صارتمش في الـ
+
+896
+01:27:55,170 --> 01:28:02,810
+Pluripotent أو في الخلية الأولى، لأ، في مرحلة لاحقة،
+
+897
+01:28:02,810 --> 01:28:12,790
+وبتكون تعطي مشكلة في نصف الخلايا، فهنا
+
+898
+01:28:12,790 --> 01:28:16,150
+بيحطون
+
+899
+01:28:16,150 --> 01:28:22,530
+أمثلة مثلًا الـ Marfan Syndrome، وهو Autosomal
+
+900
+01:28:22,530 --> 01:28:31,770
+Dominant Disorder. طيب، باجي أنا بشوف هذه العائلة
+
+901
+01:28:31,770 --> 01:28:38,610
+الرجل هذا، ماشي، عند زوجتين، أو على فترتين في حياته،
+
+902
+01:28:38,610 --> 01:28:50,970
+الزوجة مثلاً، فمنهم جاب ولد وابنة مصابين، يعني هذول
+
+903
+01:28:50,970 --> 01:28:57,650
+مش أشقاء، يعني أخوة من الأب فقط، والأمهات مختلفات،
+
+904
+01:28:57,650 --> 01:29:05,790
+واثنين مصابين، ماشي؟ شو بنقدر نقول عن هذه العائلة؟
+
+905
+01:29:05,790 --> 01:29:11,570
+إحنا بنعرف بالنسبة للـ Marfan Syndrome إنه
+
+906
+01:29:11,570 --> 01:29:16,710
+Autosomal Dominant، يعني واضح، المشترك بين أمه وأبيه،
+
+907
+01:29:16,710 --> 01:29:22,330
+والأصل إنه كان، إنه مصاب، بما أنه غير مصاب، لما قاعد
+
+908
+01:29:22,330 --> 01:29:27,670
+أدرس الجينات تبعته، راح ألاقي في الغالب إنه صار
+
+909
+01:29:27,670 --> 01:29:31,590
+معاه ظاهرة إنه عنده الـ mutation، بس الـ mutation
+
+910
+01:29:31,590 --> 01:29:38,040
+مش في الخلية الأولى من خلايا لما تكونت، يعني مش الطفرة
+
+911
+01:29:38,040 --> 01:29:42,060
+موجودة في كل الخلايا، إنما موجودة في جزء من الخلايا،
+
+912
+01:29:42,060 --> 01:29:46,540
+وموجودة في جزء من الخلايا اللي في الخصية عنده، اللي
+
+913
+01:29:46,540 --> 01:29:56,360
+هي خلّت ولاده وبناته عندهم مشكلة، هنا مثال آخر، ماشي،
+
+914
+01:29:56,360 --> 01:30:02,540
+برضه على إنه عائلة عندها X-linked، اللي هو Recessive
+
+915
+01:30:02,540 --> 01:30:06,560
+Duchenne Muscular Dystrophy، البكر قريب من الدشين
+
+916
+01:30:06,560 --> 01:30:11,760
+Muscular Dystrophy، برضه سبب لضعف العضلات، بس الدشين
+
+917
+01:30:11,760 --> 01:30:17,100
+بيكون Very Severe، بيبدأ من الطفولة المبكرة، وبيبين
+
+918
+01:30:17,100 --> 01:30:22,400
+بشكل قوي كثير، وعلى سن الـ 12، 14 سنة الطفل بموت
+
+919
+01:30:22,400 --> 01:30:27,310
+لأنه بيصير عنده Respiratory Failure، البكر إبرة عن
+
+920
+01:30:27,310 --> 01:30:32,030
+نوع ثاني برضه، نفس الشيء في نفس الـ Protein، بس درجة
+
+921
+01:30:32,030 --> 01:30:38,650
+أخف، فبيبدأ بشكل متأخر، وبيكون بيعيشوا مدة أطول،
+
+922
+01:30:38,650 --> 01:30:45,310
+ماشي، فبرضه هنا، هاي امرأة زوجت رجلين في مرحلتين في
+
+923
+01:30:45,310 --> 01:30:52,890
+حياتها، فبرضه جابت ولاد بهذا الشكل الملاحظ، هذول،
+
+924
+01:30:52,890 --> 01:31:00,130
+يعني هاي Autosomal، ماشي، "dominant" هنا، لأنه "males"
+
+925
+01:31:00,130 --> 01:31:05,790
+بس مافيش "females" affected، والـ "female" يعني لما
+
+926
+01:31:05,790 --> 01:31:10,330
+أنا جيت درستها، كان فيها "no mutation"، لما بدي أدرس
+
+927
+01:31:10,330 --> 01:31:15,370
+أنا والله باخد الدم، عادة "peripheral blood"، وببحث
+
+928
+01:31:15,370 --> 01:31:20,010
+الجينات فيها، ما أخدت الـ "ovary" تبع هذه المرأة
+
+929
+01:31:20,010 --> 01:31:23,750
+ولا أخدت الـ "testicle tissue" تبع هذا الرجل، حتى
+
+930
+01:31:23,750 --> 01:31:24,870
+أشوف الـ mutation
+
+931
+01:31:28,240 --> 01:31:33,260
+الـ Mutation في الـ Somatic tissues مش موجود، يعني
+
+932
+01:31:33,260 --> 01:31:40,420
+في الأنسجة العادية زي الدم، بينما لو روحنا على الـ
+
+933
+01:31:40,420 --> 01:31:44,020
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+934
+01:31:44,020 --> 01:31:44,200
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+935
+01:31:44,200 --> 01:31:46,240
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+936
+01:31:46,240 --> 01:31:46,820
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+937
+01:31:46,820 --> 01:31:47,780
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+938
+01:31:47,780 --> 01:31:49,000
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+939
+01:31:49,000 --> 01:31:49,020
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+940
+01:31:49,020 --> 01:31:53,280
+الـ الـ الـ الـ الـ الـ الـ الـ
+
+941
+01:31:53,280 --> 01:31:59,130
+الـ، هذه ظاهرة موجودة، وأحيانًا بلاقي عائلات بهذا
+
+942
+01:31:59,130 --> 01:31:59,530
+الشكل.
+
+943
+01:32:03,250 --> 01:32:08,390
+فدكتور، في كريم بيسأل، بيقول: يعني إحنا لو
+
+944
+01:32:08,390 --> 01:32:11,530
+رجعنا في شجرة العائلة، بنقول فلان أخد المرض من أبوه
+
+945
+01:32:11,530 --> 01:32:15,070
+مثلًا، وأبوه أخده من جده، لكن الطفرة الأساسية اللي
+
+946
+01:32:15,070 --> 01:32:19,450
+عملت كل هذا، هي طفرة جنسية زي اللي أنت يعني حكيت
+
+947
+01:32:19,450 --> 01:32:24,450
+عنها، بتصير يعني خلال اللي هو الانقسام تبع الخلايا،
+
+948
+01:32:24,450 --> 01:32:28,070
+يعني هي اللي بتسبب إن المرض يبدأ، ويتم توارثه عبر
+
+949
+01:32:28,070 --> 01:32:36,860
+الأجيال، اه، بس لازم حتى تحدث بهذا الشكل، أنه تكون فيه
+
+950
+01:32:36,860 --> 01:32:43,560
+حتى تقدر تكمل وتتكاثر، ماشي؟ يعني هنا لما أشوف عائلة
+
+951
+01:32:43,560 --> 01:32:51,060
+بهذا الشكل، شايف عليه يعني، وجيت أنا عارف وين
+
+952
+01:32:51,060 --> 01:32:56,780
+الطفرة، عارفها وين هي، وشايفها وين هي، وأجي أدرس
+
+953
+01:32:56,780 --> 01:33:05,400
+الأب في الحالة هذه، ولاقي مش عنده، شو بدي أقول؟
+
+954
+01:33:05,400 --> 01:33:10,960
+ممكن واحد يقول: يمكن هو مش أبوهم، يعني إن النساء
+
+955
+01:33:10,960 --> 01:33:17,100
+هذول، أبصر إيش عملوا، وهذا هو مش الأب لهذه الأطفال
+
+956
+01:33:17,100 --> 01:33:22,920
+مثلًا، ممكن هذا يكون ظاهر، بس الفكرة إنه أنا لما
+
+957
+01:33:22,920 --> 01:33:27,560
+ادورت على الـMutation في هذه الحالة، دورت في الـ
+
+958
+01:33:27,560 --> 01:33:33,620
+Peripheral Blood، ماشي؟ فأنا دورت في الدم، الدم مش هو
+
+959
+01:33:33,620 --> 01:33:38,060
+اللي بيعطي الـ Sperm ولا اللي بيعطينا الـ Ova، اللي
+
+960
+01:33:38,060 --> 01:33:44,060
+هي لها دخل في نقل الصفة الوراثية، فاهم عليّ؟ يعني
+
+961
+01:33:44,060 --> 01:33:48,000
+هو الفكرة اللي بدي أقولها لك إياها، إنه أنا ممكن
+
+962
+01:33:48,000 --> 01:33:54,700
+تجيني حالة زي هيك، بقول: Hi، بما إنه سائد، وأنا عارف
+
+963
+01:33:54,700 --> 01:34:01,220
+إنه سائد، إذا الأب لازم كان يكون مصاب، فإذا أنا دورت
+
+964
+01:34:01,220 --> 01:34:07,260
+بشكل سطحي وسريع، وبالـ blood بس، بلاقي إنه مثلًا ممكن
+
+965
+01:34:07,260 --> 01:34:11,560
+ما يلاقيش إشي، وبالتالي أدخل في مشكلة، عشان بدي أحاول
+
+966
+01:34:11,560 --> 01:34:17,620
+أفسر، بينما لو أخدت منه من الـ testicle tissue ولا
+
+967
+01:34:17,620 --> 01:34:24,170
+cells، أو أخدت الـ sperms تبعينه ودرستهم، بلاقي فعلًا
+
+968
+01:34:24,170 --> 01:34:27,510
+وقتها الـ mutation موجودة، فاهم عليّ كده؟ فهذه
+
+969
+01:34:27,510 --> 01:34:31,770
+النقطة اللي بدنا نذكرها هنا، أنه أحيانًا أنه يعني
+
+970
+01:34:31,770 --> 01:34:38,150
+الأمر مُعقّد، الـ dominant والـ recessive والـ X
+
+971
+01:34:38,150 --> 01:34:41,610
+-linked، والـ dominant والـ recessive، كل هذه
+
+972
+01:34:41,610 --> 01:34:47,610
+الظواهر هي بشكل عام مُبدأي، فما نقعد نأخذ individual
+
+973
+01:34:47,610 --> 01:34:57,250
+families، individual، يعني كأستاذ، بدي أكون حذر أكثر، أنه
+
+974
+01:34:57,250 --> 01:35:02,390
+ما تكون صارت أنّه شغل زي هيه، أنّ بعض خلايا الإنسان
+
+975
+01:35:02,390 --> 01:35:07,770
+هذا طبيعية، وبعضهم mutated، فحسب، إذا الـ mutation هذه
+
+976
+01:35:07,770 --> 01:35:12,910
+في الـ testicles وفي الـ ovaries، رح ينتج عنها أنه
+
+977
+01:35:12,910 --> 01:35:17,790
+أنا ممكن ما ألاقي الشيء اللي بدور عليه، فمعليش
+
+978
+01:35:20,510 --> 01:35:26,130
+فاهمين كيف؟ يعني أنّ الأمر أحيانًا مُعقّد، وبدي الواحد
+
+979
+01:35:26,130 --> 01:35:35,230
+ينتبه، يعني قبل، خصوصًا يعني بالذات يعني أشياء زي
+
+980
+01:35:35,230 --> 01:35:38,810
+هيك، ممكن واحد يصير شكّ: هذا أبوي ولا مش أبوي مثلًا،
+
+981
+01:35:38,810 --> 01:35:45,620
+يعني شيء زي هيك، يعني، الـ، خصوصًا، يعني ممكن تصير
+
+982
+01:35:45,620 --> 01:35:51,560
+وراها جرائم، ممكن تصير حوادث قتل، يعني إيش، إذا الواحد
+
+983
+01:35:51,560 --> 01:35:59,900
+مثلًا بيدعي فيه إنه شيء مش سليم، أو كذا، يعني ممكن
+
+984
+01:35:59,900 --> 01:36:03,870
+يكون شيء خطير يعني، ولما واحد يدرس المادة الوراثية
+
+985
+01:36:03,870 --> 01:36:07,570
+ويدور على الـ Genetic Mutation، ولا يدرس بـ Degree
+
+986
+01:36:07,570 --> 01:36:13,050
+وكذا، يكون دقيق، بس يكون منتبه لكل الاحتمالات،
+
+987
+01:36:13,050 --> 01:36:18,130
+وأحيانًا الـ Lethal Genes، ظاهرة بتخربط لك النسب،
+
+988
+01:36:18,130 --> 01:36:24,010
+وبتخلي أشياء تكون بطريقة مختلفة، أو إنه Mutation في
+
+989
+01:36:24,010 --> 01:36:28,210
+جزء من الخلايا، مش في كل الخلايا، وإذا جزء من
+
+990
+01:36:28,210 --> 01:36:32,270
+الخلايا، إذا من الجزء اللي ممكن ينتقل، بيختلف عن جزء
+
+991
+01:36:32,270 --> 01:36:36,970
+اللي لا يمكن أن ينتقل، يعني لو شاء موجود فحسب، أنتَ
+
+992
+01:36:36,970 --> 01:36:41,370
+على وين بتدور، على إيش بتدور، بتطلع لك النتيجة، وبدك
+
+993
+01:36:41,370 --> 01:36:43,850
+تقراها بشكل سليم، ماشي؟
+
+994
+01:36:49,070 --> 01:36:55,470
+هنا برضه، يعني برضه بـ degree، Paraganglioma
+
+995
+01:36:55,470 --> 01:37:02,910
+Syndrome I، من الأمراض، ودائمًا SDHD، الـ Capital
+
+996
+01:37:02,910 --> 01:37:07,350
+Letter، هو اللي يعني الـ Gene، بدي يكون بيأشر على
+
+997
+01:37:07,350 --> 01:37:13,750
+البروتين اللي دخل، فهنا درسوا عائلة معينة، وشافوا
+
+998
+01:37:13,750 --> 01:37:20,460
+يعني، لما أنا شوفت حاجة زي هيك، أول شيء اللي affected
+
+999
+01:37:20,460 --> 01:37:28,500
+males و females، هذا يعني بدي تكون شو اسمه، قضية
+
+1000
+01:37:28,500 --> 01:37:40,140
+تكون، يعني X-linked، أتأكد، يعني إنه مش، مش قضية X
+
+1001
+01:37:40,140 --> 01:37:45,080
+-linked، يعني لأنه فيه males، فيه فيه فيه females، و
+
+1002
+01:37:45,080 --> 01:37:50,010
+فيه males مصابين، فهي يعني ناحية بتعقّد الموضوع،
+
+1003
+01:37:50,010 --> 01:37:55,170
+فهذا بيفرجيكم درجات تعقيد الموضوع هذا من الأمراض
+
+1004
+01:37:55,170 --> 01:38:01,530
+المهمة كثير، وهي autosomal dominant، قضية الـ
+
+1005
+01:38:01,530 --> 01:38:08,470
+Huntington's disease، ما أعرفش إذا بتعرفوا عنه، يسموها
+
+1006
+01:38:08,470 --> 01:38:13,790
+مرات Huntington's Korea، حد
+
+1007
+01:38:13,790 --> 01:38:18,200
+بيعرِف إيش عن هذا المرض؟ مرض Huntington، اسم الزلمة
+
+1008
+01:38:18,200 --> 01:38:23,400
+هذا اللي وصفه، يعني
+
+1009
+01:38:23,400 --> 01:38:32,660
+هو مرض، صراحة، مشكلته إنه مرض مرعب، يعني الفكرة
+
+1010
+01:38:32,660 --> 01:38:39,000
+أحيانًا الأمراض الوراثية، خصوصًا اللي بتصير بعدين،
+
+1011
+01:38:39,000 --> 01:38:45,990
+شديدة، وبتكون قاتلة، ويعني بتأثر على الإنسان، فيه يبدو
+
+1012
+01:38:45,990 --> 01:38:50,450
+إنه عندهم معرفة مخصوصة للموضوع، يمكن من الـBio فيه
+
+1013
+01:38:50,450 --> 01:38:53,050
+بيقولوا إنه تراكم الحمض الأميني Glutamate، و
+
+1014
+01:38:53,050 --> 01:38:57,370
+mutation في amino acid، وبيظهر بعد سن الأربعين، على
+
+1015
+01:38:57,370 --> 01:38:59,930
+ما أتجابلها، ما بتكون ظاهرة بشكل واضح، يعني كل هذه
+
+1016
+01:38:59,930 --> 01:39:05,970
+المعلومات طرحوها، نعم، ماشي، فهي الفكرة، يعني إن مرض
+
+1017
+01:39:05,970 --> 01:39:12,570
+بيسبب الشلل، وبيسبب عدم القدرة على الحركة وعلى التنفس،
+
+1018
+01:39:12,570 --> 01:39:20,650
+والوفاة المبكرة، بس عادة الأمراض الوراثية، يعني الناس
+
+1019
+01:39:20,650 --> 01:39:26,970
+بالذات لما يظهر المرض على عمر مبكر، بيجوزوش المصاب،
+
+1020
+01:39:26,970 --> 01:39:31,950
+بيخلفش هذا المصاب، وبالتالي يعني بالذات لما نقول
+
+1021
+01:39:31,950 --> 01:39:38,750
+autosomal dominant، بتلاقي إنه يعني بيظل المصدر
+
+1022
+01:39:38,750 --> 01:39:44,570
+الرئيسي للمرض هو طُفرات جديدة، يعني بتحدث بين الناس
+
+1023
+01:39:45,110 --> 01:39:51,530
+ماشي، لسبب أو لآخر، أشعاع، كيمويات، أمراض فيروسية، شيء
+
+1024
+01:39:51,530 --> 01:39:57,590
+بيحدث بسبب فترة، يعني، فالـ Huntington مشكلته إنه
+
+1025
+01:39:57,590 --> 01:40:02,670
+بيبدأ على سن الأربعين مثلًا، فالمشكلة لما يبدأ على
+
+1026
+01:40:02,670 --> 01:40:08,090
+سن الأربعين، إنه في الغالب بتلاقي الإنسان على سن
+
+1027
+01:40:08,090 --> 01:40:14,630
+العشرين، تزوج، وجاب ولاد وبنات، وبعدين
+
+1028
+01:40:14,630 --> 01:40:18,990
+بيبقى معاه المرض، فهذه مشكلته، عيبه يعني، بالنسبة لما
+
+1029
+01:40:18,990 --> 01:40:24,130
+يعني عائلة تنتبه، أو شخص ينتبه أن والده عنده مشكلة
+
+1030
+01:40:24,130 --> 01:40:31,450
+Huntington's، الـ Huntington's مشكلته أنه بيجيك
+
+1031
+01:40:31,450 --> 01:40:37,650
+إنسان مثلًا شاف معاناة والده أو والدته في المرض هذا،
+
+1032
+01:40:37,650 --> 01:40:43,980
+وعارف أنه مرض وراثي سائد، يعني إذا نسخة واحدة خلاص
+
+1033
+01:40:43,980 --> 01:40:52,780
+الإنسان مصاب، وتلاقي يعني هنا قضية الـ Age of onset،
+
+1034
+01:40:52,780 --> 01:41:01,040
+يعني بيحاولوا يظهروها إنه كل ما نزلنا لتحت، بيكون
+
+1035
+01:41:01,040 --> 01:41:07,280
+العمر اللي بتبين فيه المشكلة بشكل أصغر، يعني بيكون
+
+1036
+01:41:07,280 --> 01:41:12,930
+إنسان بيظهر عليه المشكلة، فهي الفكرة إنه بظهر بشكل
+
+1037
+01:41:12,930 --> 01:41:18,510
+متأخر، يعني بعد ما الإنسان بيكون عائلته، بيجيب ولاده،
+
+1038
+01:41:18,510 --> 01:41:24,330
+بنات وكذا، وبعدين بيشوف المرض، والمعاناة في كثير من
+
+1039
+01:41:24,330 --> 01:41:28,450
+الناس، في الحالات الوراثية تمامًا، راح نأخذ بعدين عن
+
+1040
+01:41:28,450 --> 01:41:32,970
+الـGenetic Counseling، وكيف تنصح، وشو تنصح الأهل،
+
+1041
+01:41:32,970 --> 01:41:41,370
+وكذا، فالفكرة بتكون إنه أحيانًا لما يجيك إنسان ويكون
+
+1042
+01:41:41,370 --> 01:41:47,350
+عنده، عند والده أو والدته مثل هيك مرض، ويصير هو يسأل،
+
+1043
+01:41:47,350 --> 01:41:52,670
+طب شو وضعي أنا؟ أتزوج، أجيب ولاد وبنات، يصير عندهم
+
+1044
+01:41:52,670 --> 01:41:57,610
+المرض؟ ولا أوقف النسل، وما أسويش شيء؟ في ناس أحيانًا
+
+1045
+01:41:57,610 --> 01:42:03,820
+بنتحرّف في ثقافات وفي مجتمعات وكذا، بتلاقيهم
+
+1046
+01:42:03,820 --> 01:42:09,560
+بياخذوا على إنه إنك أنت تدرس الـMutation، وتشوف
+
+1047
+01:42:09,560 --> 01:42:17,000
+موجودة، مش موجودة، وهنا شكله، الـ، الـ، فيه
+
+1048
+01:42:17,000 --> 01:42:20,960
+repeats معينة في منطقة معينة، هي بتكون الـColony
+
+1049
+01:42:20,960 --> 01:42:30,040
+إنّه الـHD-Gene، الـHuntington Disease Gene، بتلاقي في
+
+1050
+01:42:30,040 --> 01:42:35,460
+قطعة معينة تتكرر بنسب معينة، حسب الـ copies، وتعتمد
+
+1051
+01:42:35,460 --> 01:42:40,060
+حسب العدد، يعني كل ما زاد عدد الـ copies من الـ
+
+1052
+01:42:40,060 --> 01:42:46,680
+inserts هدول، يعني 100، 100، 110، بتلاقي الـage of
+
+1053
+01:42:46,680 --> 01:42:52,940
+onset صغير كثير، وبيكون الإنسان بيظهر عليه
+
+1111
+01:48:23,530 --> 01:48:29,410
+lineage بس الأم أو الأنثى هي التي تقدر تنقل المرض
+
+1112
+01:48:29,410 --> 01:48:34,210
+لولادها وبناتها، ذكور وإناث، وليس هناك فرصة وإنما
+
+1113
+01:48:34,210 --> 01:48:38,190
+الأولاد المصابون أو الذكور المصابون لا يقدرون
+
+1114
+01:48:38,190 --> 01:48:42,330
+ينقلوا هذا المرض أو هذه الحالة مثل Adult-onset
+
+1115
+01:48:42,330 --> 01:48:45,090
+blindness  الذي هو Leber's Hereditary Optic Neuropathy
+
+1116
+01:48:45,090 --> 01:48:50,490
+كمثال على Mitochondrial DNA Disease
+
+1117
+01:48:50,490 --> 01:48:56,150
+Inherited. هذه ناحية مهمة وهي أيضًا من التعقيد في
+
+1118
+01:48:56,150 --> 01:49:01,150
+الظواهر التي أحيانًا  يجب أن تفهمها لتفسير
+
+1119
+01:49:01,150 --> 01:49:05,740
+بعض العائلات وبعض الحالات. والله يعطيكم العقل في حد
+
+1120
+01:49:05,740 --> 01:49:11,040
+عندكم أسئلة؟
+
+1121
+01:49:11,040 --> 01:49:14,380
+يعني
+
+1122
+01:49:14,380 --> 01:49:19,340
+لن نسأل أحدًا الآن، إن شاء الله. إذا، إن شاء الله،
+
+1123
+01:49:19,340 --> 01:49:25,460
+نتلاقى بعد غد ونتكلم إن شاء الله بخصوص الـ… ماذا
+
+1124
+01:49:25,460 --> 01:49:28,400
+اسمها يا دكتور؟ بخصوص الأسئلة، سأتواصل معك إن
+
+1125
+01:49:28,400 --> 01:49:34,050
+شاء الله ونتفق على، على الأقل، سنرى، أظن أنه مع
+
+1126
+01:49:34,050 --> 01:49:41,930
+نهاية الـ course إن شاء الله، كخطة، كـ أسئلة، أظن
+
+1127
+01:49:41,930 --> 01:49:46,910
+أنها تحتوي على 400 سؤال. هذا ما رأيته. على خير، ولكن المشكلة هي أنني
+
+1128
+01:49:46,910 --> 01:49:51,890
+لستُ قادرًا أو لن نكون قادرين على الدخول في تفاصيل
+
+1129
+01:49:51,890 --> 01:49:59,180
+جميع الأمراض وجميع الحالات، ولذلك، سنبدأ بالمبادئ، وعلى كل
+
+1130
+01:49:59,180 --> 01:50:03,520
+واحد أن يكون لديه إمكانية الرجوع إلى مرجع مناسب ليأخذ
+
+1131
+01:50:03,520 --> 01:50:08,400
+معلومة تقوده في كيفية التعامل مع الحالة، إن شاء الله
+
+1132
+01:50:08,400 --> 01:50:12,540
+طيب، وبخصوص ورقة العمل، سنبقى على تواصل للاتفاق على القليل
+
+1133
+01:50:12,540 --> 01:50:16,240
+منها إن شاء الله. إن شاء الله. أهلاً و
+
+1134
+01:50:16,240 --> 01:50:18,760
+سهلاً. مع السلامة.
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/d-MRFWD54MU_raw.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/d-MRFWD54MU_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..6acbc8b894090211e9b457541887fee620aa2f1f
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/d-MRFWD54MU_raw.srt
@@ -0,0 +1,4584 @@
+1
+00:00:00,000 --> 00:00:03,920
+وهو الـ Single Gene Inheritance اللي هما الـ
+
+2
+00:00:03,920 --> 00:00:10,240
+Mandelian Diseases حكيت أنا يعني من قبل أنه في عنا
+
+3
+00:00:10,240 --> 00:00:15,460
+عدد أمثلة قليل عادة لـ Chromosomal Disease الـ
+
+4
+00:00:15,460 --> 00:00:20,580
+Chromosomal Disease لما يكون كرموزوم كامل أو جزء
+
+5
+00:00:20,580 --> 00:00:27,980
+من كرموزوم بيصير فيه مشكلة زي Deletion، Copy
+
+6
+00:00:27,980 --> 00:00:37,440
+Numberزيادة في عدده خربطة في القطعة بتكون فيها
+
+7
+00:00:37,440 --> 00:00:45,000
+مشكلة كبيرة بتكون وعادةً يعني هذول الأمراض ما يعني
+
+8
+00:00:45,000 --> 00:00:52,400
+صحيح يعني أمثلة فاقعة وكبيرة ويكون فيها مشاكل
+
+9
+00:00:52,400 --> 00:00:57,320
+كثيرة بس في الغالب هي بالـ Newborns بتسبب
+
+10
+00:00:57,320 --> 00:01:04,100
+Abortionsعادةً ما بتكون لأحتمالية
+
+11
+00:01:04,100 --> 00:01:12,000
+إنه يكون موجود في شخص حي بعد ذلك إلا إذا صارت
+
+12
+00:01:12,000 --> 00:01:16,340
+إشكالية أو مشكلة في قضية إنه يكون Balanced
+
+13
+00:01:16,340 --> 00:01:21,940
+Translocation يعني في قطعة رايحة من مكان صحيحي
+
+14
+00:01:21,940 --> 00:01:27,390
+مفقودة بس بتكون في مكان آخر، فكلها أمثلة علىالـ
+
+15
+00:01:27,390 --> 00:01:31,810
+Chromosomal Diseases وأخذنا مثال على الـ
+
+16
+00:01:31,810 --> 00:01:35,570
+Subchromosomal Diseases الـ Digard Syndrome بذكركم
+
+17
+00:01:35,570 --> 00:01:39,390
+فيه لأنه فيه مبادئ كثيرة بتفيدكم في الـ Immunology
+
+18
+00:01:39,390 --> 00:01:43,470
+كمان ومفيدة الآن الـ Mendelian Diseases الـ
+
+19
+00:01:43,470 --> 00:01:50,130
+Mendelian Diseases برضه يعني أنه Disease أو مشكلة
+
+20
+00:01:50,130 --> 00:01:57,000
+نتيجة خلل في جين واحدالـ Group الثالث اللي راح
+
+21
+00:01:57,000 --> 00:02:02,200
+ناخدها بعدين واللي هي أشعك بشكل أكبر بكثير كعدد
+
+22
+00:02:02,200 --> 00:02:06,760
+ولكن يمكن
+
+23
+00:02:06,760 --> 00:02:11,860
+دراستها صعبة من ناحية إنه مش جين واحد المسؤول لما
+
+24
+00:02:11,860 --> 00:02:15,980
+نشترك عدد كبير من الجينات يعني زي في الـ Bronchial
+
+25
+00:02:15,980 --> 00:02:20,260
+Asthma الربو القصبي تقريبًا فيه خوالي خمسين جين
+
+26
+00:02:20,260 --> 00:02:24,810
+بيشتركوافبتلاقي عدد كبير من الجينات كلهم مشتركين
+
+27
+00:02:24,810 --> 00:02:31,150
+تتسبب بالمرض أو تتسبب بإعطانا الصفة الفلانية فاحنا
+
+28
+00:02:31,150 --> 00:02:39,310
+دايماً لما نتكلم عن المبادئ المناع الوراثة نتكلم
+
+29
+00:02:39,310 --> 00:02:44,430
+عن أنه فيه Genotype وPhenotype لما ندرس بشكل
+
+30
+00:02:44,430 --> 00:02:50,880
+تفصيلي ودقيقالجينات وكيف شكلها وكيف ترتيبها وماذا
+
+31
+00:02:50,880 --> 00:02:55,120
+بتعطي وماذا بتسوي هذا بيكون اسمه الـ Genotype
+
+32
+00:02:55,120 --> 00:03:01,020
+وأحيانًا أكثر من Genotype يعطينا Phenotype واحد أو
+
+33
+00:03:01,020 --> 00:03:05,820
+كيف كل .. يعني شو المظهر الأخير راح يكون على زي
+
+34
+00:03:05,820 --> 00:03:11,540
+مثلًا هنا شكل الإنسان، شكل أنفه، شكل هون جلده،
+
+35
+00:03:11,540 --> 00:03:16,570
+طوله، عرضه وكذا وكذا، كلها بتلاقيها أمورمرتبطة
+
+36
+00:03:16,570 --> 00:03:21,430
+بالجينات وبتكون أنه فيه علاقة بين الـ Genotype
+
+37
+00:03:21,430 --> 00:03:25,850
+والـ Phenotype، هذه قضية مهمة من القضايا المهمة
+
+38
+00:03:25,850 --> 00:03:32,250
+الثانية، الواحد يفهم بالنسبة
+
+39
+00:03:32,250 --> 00:03:35,670
+لمن
+
+40
+00:03:35,670 --> 00:03:42,240
+اتعرض لحالة زي هيكأو إذا بدّي يكون له دور يسبب
+
+41
+00:03:42,240 --> 00:03:46,040
+تقدم الواحد في الطب والعلم من ناحية الأمراض
+
+42
+00:03:46,040 --> 00:03:52,840
+الوراثية إنه من أول ما تجيني الحالة وخلال ما عندي
+
+43
+00:03:52,840 --> 00:03:58,000
+أشخاص أحياء عندهم معلومات وكذا، برسم شجرة العيلة
+
+44
+00:03:58,000 --> 00:04:05,400
+شجرة العيلة اللي هي بنسميها الـ Pedigree لها رموز،
+
+45
+00:04:05,400 --> 00:04:11,430
+بدّي الواحد يكون فاهمهملمّا نشوف رموز المربع، هذا
+
+46
+00:04:11,430 --> 00:04:17,250
+Male، المدائرة هي Female، إذا حاطينها شكل معين، مش
+
+47
+00:04:17,250 --> 00:04:26,230
+محدد، أحنا ماشينا على الرموز هذه ومعانيها، وهذه،
+
+48
+00:04:26,230 --> 00:04:28,990
+يعني، راح نستفيد منها على الأقل في المحاضرة
+
+49
+00:04:28,990 --> 00:04:33,960
+القادمة، المحاضرة هذه، في إن كيف منها نستنتجما هي
+
+50
+00:04:33,960 --> 00:04:39,020
+نوعية الـ Inheritance؟ ما هي نوعية الـ «Mendelian
+
+51
+00:04:39,020 --> 00:04:42,740
+Diseases»؟ هل هي تزامة الـ «dominant» أو «ex
+
+52
+00:04:42,740 --> 00:04:46,580
+-linked» أو «recessive»؟ ما هي وصفها، بحسب ما بقى
+
+53
+00:04:46,580 --> 00:04:50,880
+أنا بشوف، بحسب الـ «degree» اللي برسمه، نتيجة إن
+
+54
+00:04:50,880 --> 00:04:56,920
+أنا أخذ المعلومات الكاملة من المريض، أهل المريض،
+
+55
+00:04:56,920 --> 00:05:03,900
+أبائه، أجداده، أبناءه، أحفاده، إخوانه، وكدهبحاول
+
+56
+00:05:03,900 --> 00:05:09,040
+أخد المعلومات الكامة فهذه ناحية مهمة كثير وهكذا
+
+57
+00:05:09,040 --> 00:05:16,540
+معاني الرموز المستخدمة في الـ «دجري تشارت» أو في
+
+58
+00:05:16,540 --> 00:05:22,460
+شجرة العائلة اللي لازم ترسم وبكون لها معاني مهمة
+
+59
+00:05:22,460 --> 00:05:28,960
+وهي شغلة مهمة دكتور، فيه إمكانية تعمل share screen
+
+60
+00:05:28,960 --> 00:05:35,870
+لأنه …؟ أنا هتسوّرلأ، مش موجود، مش مبين، دقيقة،
+
+61
+00:05:35,870 --> 00:05:47,090
+آسف، ايه؟ وين؟ ايه؟ زوم؟
+
+62
+00:05:47,090 --> 00:05:57,630
+ليش بكايل يـSign in؟ ده كيف؟ ايه؟
+
+63
+00:06:02,350 --> 00:06:11,950
+«شيرس كريه» «شيرس
+
+64
+00:06:11,950 --> 00:06:16,130
+كريه» «شيرس
+
+65
+00:06:16,130 --> 00:06:16,310
+كريه» «شيرس كريه» «شيرس كريه» «شيرس كريه» «شيرس
+
+66
+00:06:16,310 --> 00:06:16,310
+كريه» «شيرس كريه» «شيرس كريه» «شيرس كريه» «شيرس
+
+67
+00:06:16,310 --> 00:06:16,730
+كريه» «شيرس كريه» «شيرس كريه» «شيرس كريه» «شيرس
+
+68
+00:06:16,730 --> 00:06:17,250
+كريه» «شيرس كريه» «شيرس كريه» «شيرس كريه» «شيرس
+
+69
+00:06:17,250 --> 00:06:22,070
+كريه» «شيرس كريه» «شيرس كريه» «شيرس كريه» «شيرس
+
+70
+00:06:22,070 --> 00:06:25,750
+كريه»
+
+71
+00:06:25,750 --> 00:06:30,170
+«شيرس كريه» «شيرس كريه» «شيرس كريه» «شيرس كريه»
+
+72
+00:06:30,170 --> 00:06:35,140
+«شيرس كريه»معاني الرموز المستخدمة الـ Divorced،
+
+73
+00:06:35,140 --> 00:06:39,820
+Married، Consanguinity، زواج قارب، Dizygotic،
+
+74
+00:06:39,820 --> 00:06:44,380
+Monozygotic، Adopted into family، Adopted out of
+
+75
+00:06:44,380 --> 00:06:53,090
+family، إذا في عملية تبني داخل أو خارج العائلةفي
+
+76
+00:06:53,090 --> 00:06:56,030
+الـ broadband اللي هي الحالة الأولى اللي تم
+
+77
+00:06:56,030 --> 00:07:01,510
+اكتشافها وعلى ضوها تم دراسة وضع العائل هذه أو
+
+78
+00:07:01,510 --> 00:07:07,290
+الاهتمام بيها فكل جوانب لازم الواحد يعرفها إحنا
+
+79
+00:07:07,290 --> 00:07:16,970
+يعني هنا المبدأ الثاني في شجرة العائلة غير قضية
+
+80
+00:07:16,970 --> 00:07:23,840
+الـ «إن نفهمهم، شوفوا كيف معناته، كيف صارت»قضية
+
+81
+00:07:23,840 --> 00:07:28,240
+الـ، يعني أحيانًا بنقول «3rd degree» «2nd degree»
+
+82
+00:07:28,240 --> 00:07:33,540
+«3rd degree relative» بهذا الشكل لما مثلًا أنا
+
+83
+00:07:33,540 --> 00:07:40,580
+أتكلم عن احتمالية الإصابة في تصلب شرين القلب مرتبط
+
+84
+00:07:40,580 --> 00:07:46,020
+بإنه التاريخ العقلي يعني من العوامل الخطورة الكبرى
+
+85
+00:07:46,020 --> 00:07:51,400
+الـMajor Risk Factors قضية إنه يكون أنا Family
+
+86
+00:07:51,400 --> 00:07:54,850
+Historyفالـ Family History يعرف على إنه «first
+
+87
+00:07:54,850 --> 00:07:59,010
+degree relative sudden death» أو «MI» «at young
+
+88
+00:07:59,010 --> 00:08:05,590
+age» أقل من 55 للـ «females» و45 للـ «males» مثلاً
+
+89
+00:08:05,590 --> 00:08:09,410
+فالتعريف هذا الـ «definition» هذا بشترط «first
+
+90
+00:08:09,410 --> 00:08:13,390
+degree relative» فلو أخذنا الشخص هذا اللي موجود
+
+91
+00:08:13,390 --> 00:08:18,150
+عنده سهم فبتلاقي الـ «first degree» هم إخوانه
+
+92
+00:08:18,150 --> 00:08:23,640
+وخواته حقين عليهم «first degree»والده ووالدته
+
+93
+00:08:23,640 --> 00:08:29,840
+وولاده وبناته هذولة الـ First-degree relative اللي
+
+94
+00:08:29,840 --> 00:08:36,620
+هي أنثى فزوجها لا يعتبر First-degree relative جوز
+
+95
+00:08:36,620 --> 00:08:41,220
+بنتها لا يعتبر First-degree relative بينما مثلًا
+
+96
+00:08:41,220 --> 00:08:45,920
+سيدها وستها من ناحية الأب والأم هي Second-degree
+
+97
+00:08:45,920 --> 00:08:53,880
+relative حاطين عمها Second-degreeمثلًا حفيدها
+
+98
+00:08:53,880 --> 00:09:01,540
+second degree ماشي وإذا في مثلًا ابن عم يعني هو
+
+99
+00:09:01,540 --> 00:09:07,080
+أنا بالنسبة إليها الـ broadband أو اللي هنا هذا
+
+100
+00:09:07,080 --> 00:09:12,040
+أبوها، هذا عمها، ابن عمها درجة ثالثة ابن ابن عمها
+
+101
+00:09:12,040 --> 00:09:19,340
+درجة رابعة فوحيانًا بكون شخص مشترك من أكتر من جهة
+
+102
+00:09:19,340 --> 00:09:30,780
+يعني مثلًاأخوها اتزوج بنت خالة
+
+103
+00:09:30,780 --> 00:09:35,260
+بنت
+
+104
+00:09:35,260 --> 00:09:45,920
+خالة أمها، أمه يعني هذا أخوها، هذه أمه وهذه أخوها
+
+105
+00:09:45,920 --> 00:09:53,000
+فهو بيصير بالنسبة لهذا الرجل هذا خالهوبالتالي إذا
+
+106
+00:09:53,000 --> 00:09:58,900
+أخذت بنت خاله فهي درجة تالتة بالنسبة للـ broadband
+
+107
+00:09:58,900 --> 00:10:04,680
+من الدرجة التالتة ولمّا نخلّفه هذا الـ Double
+
+108
+00:10:04,680 --> 00:10:10,520
+Marriage يعني Consanguinity يعني زواج أقارب،
+
+109
+00:10:10,520 --> 00:10:16,800
+فباخدها بهذا الشكل فيعني إحنا لما نيجي نتطلع على
+
+110
+00:10:16,800 --> 00:10:21,210
+الـ Pedigreeشجرة عائلة المفروض نكون قادرين على فهم
+
+111
+00:10:21,210 --> 00:10:27,730
+الرموز واستيعابها ويعني معرفة معانيها وكيف نرمز
+
+112
+00:10:27,730 --> 00:10:32,950
+لكل علاقة مطلوبة فهذه نواحي مهمة حتى نستطيع بعدين
+
+113
+00:10:32,950 --> 00:10:39,750
+نعرف شو نوعية الـ Inheritance مثال على مواضيع الـ
+
+114
+00:10:39,750 --> 00:10:46,170
+Inheritance ماشي اللي هو الـ ABO Blood Group الـ
+
+115
+00:10:46,170 --> 00:10:50,470
+ABO Blood Groupالنفس الـ Group هي Carbohydrate
+
+116
+00:10:50,470 --> 00:10:57,430
+Antigen لما نتكلم على جين هو يمثل أو راح يعطي
+
+117
+00:10:57,430 --> 00:11:03,090
+البروتين البروتين في الحالة هذه هو الـ Enzyme يا
+
+118
+00:11:03,090 --> 00:11:07,130
+أما الـ A-Enzyme يا أما الـ B-Enzyme الـ Enzyme
+
+119
+00:11:07,130 --> 00:11:10,530
+هذا بغير الـ Structure تبع الـ Carbohydrate
+
+120
+00:11:10,530 --> 00:11:14,130
+Antigen اللي بيسموه الـ H-Antigen اللي موجود بالـ
+
+121
+00:11:14,130 --> 00:11:18,760
+O Blood Groupيحولوا إلى A-antigen أو B-antigen
+
+122
+00:11:18,760 --> 00:11:25,720
+فإذا الإنسان عنده two alleles AB وارثهم راح يطلع
+
+123
+00:11:25,720 --> 00:11:30,180
+الـ Phenotype AB لأن أثنانهم co-dominant لما
+
+124
+00:11:30,180 --> 00:11:34,240
+يكونوا أثنان موجودين فالمبدأ يعني بين الـA والـO
+
+125
+00:11:34,240 --> 00:11:40,060
+والـB والـO إن الـA أو الـB dominant على الـO الـO
+
+126
+00:11:40,060 --> 00:11:44,460
+هو الـRecessor والـA والـB dominantبس بين الـ A
+
+127
+00:11:44,460 --> 00:11:48,740
+والـ B فيه Co-dominant يعني إذا فيه إثنين، إثنين
+
+128
+00:11:48,740 --> 00:11:55,180
+راح يبقى إيماً فهي ناحية مهمة، ودايماً أنا بقول في
+
+129
+00:11:55,180 --> 00:12:00,220
+مواضيع المناعة ومواضيع الوراثة ومواضيع أشياء كتيرة
+
+130
+00:12:00,220 --> 00:12:05,760
+في الدنيا Transplantation، Transfusion يظل الـ ABO
+
+131
+00:12:05,760 --> 00:12:08,740
+System very، very important الواحد لازم يكون فاهمه
+
+132
+00:12:08,740 --> 00:12:14,520
+كويس، فالـ ABO Systemone of the earliest system
+
+133
+00:12:14,520 --> 00:12:19,860
+يعني «لانشتاينر» العالم اللي اكتشف الـ ABO system
+
+134
+00:12:19,860 --> 00:12:26,060
+أخد جائزة نوبل سنة الـ 1900 يعني قبل 120 سنة عشان
+
+135
+00:12:26,060 --> 00:12:31,760
+اكتشفه لأنه بيحددنا كيف علاقات blood transfusion
+
+136
+00:12:31,760 --> 00:12:34,820
+فالأصل
+
+137
+00:12:34,820 --> 00:12:41,260
+الإنسان لما يعني يكون عنده blood group معينة والـ
+
+138
+00:12:41,260 --> 00:12:46,760
+antigen cellإنه ما في خلايا مناعية تتعرف على السلف
+
+139
+00:12:46,760 --> 00:12:52,640
+الأصل بتتم القضاء عليها في مرحلة مبكرة فاللي عنده
+
+140
+00:12:52,640 --> 00:13:00,100
+A الخلايا اللي كانت ممكن تتفاعل مع الـA يعني
+
+141
+00:13:00,100 --> 00:13:05,720
+من ناحية المناعة، بتتم القضاء عليها عشان هيك في
+
+142
+00:13:05,720 --> 00:13:10,040
+الـSerum، في الـAntibody عنده بيكون عنده Anti-B،
+
+143
+00:13:10,040 --> 00:13:16,070
+ماعندهوش Anti-Aعندما أشخص أو أقوم بالـ Type
+
+144
+00:13:16,070 --> 00:13:21,670
+للإنسان هذا بحط Anti-A وAnti-B على خلايا من عندي
+
+145
+00:13:21,670 --> 00:13:29,170
+من الـ Blood-Group Reagent Anti-A وAnti-B فبصير
+
+146
+00:13:29,170 --> 00:13:33,290
+عنده Reaction للـA ومافيش Reaction للـB، Anti-B
+
+147
+00:13:33,290 --> 00:13:37,450
+الـO مافيش Reaction للطرفين الـB بالعكس والـAB
+
+148
+00:13:37,450 --> 00:13:43,340
+بتفعل مع أثنين الـABفي الـ Serum عنده ما فيه Anti
+
+149
+00:13:43,340 --> 00:13:51,280
+-A ولا فيه Anti-B فهذه قضية يعني بتكون موجودة
+
+150
+00:13:51,280 --> 00:13:56,720
+وبتكون بهذا الطريقة وبهذا الشكل فهذا مثال على
+
+151
+00:13:56,720 --> 00:14:06,540
+Locus يعني على مكان للجينات هذه وفي عندنا three
+
+152
+00:14:06,540 --> 00:14:12,510
+alleles possible يعني الـ Genotypeاللي هو القليل
+
+153
+00:14:12,510 --> 00:14:17,870
+الممكن في هذا المكان يا «O» يا «A» يا «B» والـ
+
+154
+00:14:17,870 --> 00:14:22,930
+«Phenotypes» الممكن أربعة يا «O» يا «A» يا «B» يا
+
+155
+00:14:22,930 --> 00:14:29,310
+«AB» مع ملاحظة أنه لما يكون «A» لأن الـ «A»
+
+156
+00:14:29,310 --> 00:14:32,190
+dominant على الـ «O» في الـ possibilities تكون
+
+157
+00:14:32,190 --> 00:14:37,830
+«AA» أو «AO» والـ «B» لما يكون الـ «Phenotype» «B»
+
+158
+00:14:37,830 --> 00:14:43,380
+يا إما «BB»كـ Genotype أو «بو» كـ Genotype فهي
+
+159
+00:14:43,380 --> 00:14:50,780
+المفاهيم لازم واحد يكون مستوعبها وسهلة وغاضبة عنده
+
+160
+00:14:50,780 --> 00:14:59,220
+فلمّا نيجي نشوف كيف بيصير الـ Inheritance وعلى أي
+
+161
+00:14:59,220 --> 00:15:08,020
+أساس يعني أنا بصير بعدين أحكم إنه هاي هيك، هاي
+
+162
+00:15:08,020 --> 00:15:16,500
+هيك، هاي هيكلو أخدنا مثلًا مثال نرجع بعد شوية بقى
+
+163
+00:15:16,500 --> 00:15:23,780
+دي أنا بشوف عندي إنسان في الحالة هذه شخصين من أسرة
+
+164
+00:15:23,780 --> 00:15:31,400
+مصابين ولد وابنت ماشي أو يعني حتى صار كبار بالعمر
+
+165
+00:15:31,400 --> 00:15:36,600
+بحيث أنهالبنت هذه أو الإمرأة هذه حتى عندها تلث
+
+166
+00:15:36,600 --> 00:15:44,440
+ولاد وبنت يعني صارت فيها أم لما أشوف أنا بـ degree
+
+167
+00:15:44,440 --> 00:15:53,620
+بهذا الشكل أول شيء الإصابة بين ذكور وإنسة يعني ما
+
+168
+00:15:53,620 --> 00:16:00,350
+أفرقت بين الذكر والأنفةهذا مؤشر على إنه «it is
+
+169
+00:16:00,350 --> 00:16:06,450
+autosomal» «it is not X-linked» لو X-linked كانت
+
+170
+00:16:06,450 --> 00:16:10,630
+بتلاقي الواحد فرق كبير أو فرق شديد إن مثلا الذكور
+
+171
+00:16:10,630 --> 00:16:14,270
+مصابين الإناث مافيش ولا واحدة مصابة لما يكون
+
+172
+00:16:14,270 --> 00:16:20,550
+الإصابة بين الجنسين متساوي أو ممكنة بس بفكر أكثر
+
+173
+00:16:20,550 --> 00:16:26,310
+إنها «it is autosomal» القضية الثانية هي إنهيعني
+
+174
+00:16:26,310 --> 00:16:33,750
+هذه الظاهرة ماشي لما أنا آجي أدرسها هلاقى إن الأب
+
+175
+00:16:33,750 --> 00:16:37,610
+والأم اللي هو أنا في الحالة هذه الجيل الثاني الجد
+
+176
+00:16:37,610 --> 00:16:43,390
+والجدة أو هو أنا بترتيب هذه العائلة، الشجرة
+
+177
+00:16:43,390 --> 00:16:50,850
+العائلة هذه بيكونوا حاملين للموروث
+
+178
+00:16:50,850 --> 00:16:56,110
+هذا، للـGene هذا والسبب إنه أثنينهم مش مصابينولكن
+
+179
+00:16:56,110 --> 00:17:00,690
+بطريقة ما لما أدرس بلاقي الـ «جينوطيك» أن هما
+
+180
+00:17:00,690 --> 00:17:06,330
+مستعمرين لذلك فالآن لما أتي أشوف احتمالات الـ
+
+181
+00:17:06,330 --> 00:17:11,270
+«اوتوزومال» الـ «تسيسيف الانهاريتنز» بلاقي فيه كذا
+
+182
+00:17:11,270 --> 00:17:18,730
+عنده كذا احتمال افرض ونقض هذا الجدول يعني عشان
+
+183
+00:17:18,730 --> 00:17:24,570
+نفهمه إنه أنا عندي الـ «بارنت وان» الأب الأول
+
+184
+00:17:26,150 --> 00:17:33,790
+Career، وإذا افترضنا إنه الجين الطبيعي اللي هو الـ
+
+185
+00:17:33,790 --> 00:17:40,750
+Capital R الأصلي والـ Small R هو المُصاب فإذا
+
+186
+00:17:40,750 --> 00:17:46,310
+ذكروا أنثى Parent 1 وParent 2 أثنينهم عندهم
+
+187
+00:17:46,310 --> 00:17:51,990
+Capital R وSmall R بهذا الشكل نتائج الزواج هدول
+
+188
+00:17:51,990 --> 00:17:56,530
+الأثنين راح يكون بهذه الطريقةإن الرُبُق راح يكون
+
+189
+00:17:56,530 --> 00:18:00,250
+«completely unaffected» كابيتال «R» كابيتال «R»
+
+190
+00:18:00,250 --> 00:18:05,710
+النُص راح يكونوا «unaffected carriers» عبارة عن
+
+191
+00:18:05,710 --> 00:18:11,170
+حابين للمرض بس غير مصابين اللي هو كابيتال «R» صغير
+
+192
+00:18:11,170 --> 00:18:15,670
+«R» فالكابيتال «R» بتكفي و بيصير عنده إنسان ما
+
+193
+00:18:15,670 --> 00:18:21,530
+عندهوش المرض و بيكون بس حامل إله الرُبُق بس هم الـ
+
+194
+00:18:21,530 --> 00:18:28,140
+«affected»small r – small r طبعاً يعني هذه بتتذكر
+
+195
+00:18:28,140 --> 00:18:34,680
+الواحد إنه عبارة عن احتمالات يعني هيك بنقول
+
+196
+00:18:34,680 --> 00:18:41,740
+احتمالات ويعني مثلا ممكن إنسان يقول مثلا والله
+
+197
+00:18:41,740 --> 00:18:47,560
+بالنسبة لذاكر ولا أنثى نص بنص الولادة بتكون
+
+198
+00:18:47,560 --> 00:18:51,480
+احتمالية تكون ذاكر ولا أنثى بس لما الواحد يشوفها
+
+199
+00:18:51,480 --> 00:18:57,720
+بهذا الطريقةيمكن إنسان أو عائلة تلت أو أربع أو خمس
+
+200
+00:18:57,720 --> 00:19:03,500
+بنات كله يكون أو كله مولاد يكون وبعدين مايجيش حدا
+
+201
+00:19:03,500 --> 00:19:07,340
+من الجنس الآخر يعني فهي مالة دخل شو اللي راح يصير
+
+202
+00:19:07,340 --> 00:19:10,680
+يعني مش مانعة الرُبع يعني لو جابوا أربع يعني واحد
+
+203
+00:19:10,680 --> 00:19:15,580
+منهم لازم يطلع مصاب، لأ يمكن يطلع كلهم ماحدش مصاب،
+
+204
+00:19:15,580 --> 00:19:19,280
+يطلع كلهم مصابين بس هذه الـprobabilities هذه
+
+205
+00:19:19,280 --> 00:19:25,180
+الاحتمالات اللي المفروضة في حالةزواج اتنين
+
+206
+00:19:25,180 --> 00:19:29,960
+carriers لـ Autism and Recessive Inheritance إذا
+
+207
+00:19:29,960 --> 00:19:37,700
+افترضنا إنه carrier اتزوج إنسان مصاب يعني عنده
+
+208
+00:19:37,700 --> 00:19:43,440
+small «r»، small «r»، ماشي، في الحالة هذه، الظاهرة
+
+209
+00:19:43,440 --> 00:19:51,380
+أو الـGenetic Mutationسيكون النُص الـ RR
+
+210
+00:19:51,380 --> 00:19:57,640
+unaffected career والنُص الثاني راح يكون affected
+
+211
+00:19:57,640 --> 00:20:02,880
+رر، رر، رر، رر، رر، رر، رر، رر، رر، رر، رر، رر،
+
+212
+00:20:02,880 --> 00:20:03,560
+رر، رر، رر، رر، رر، رر، رر، رر، رر، رر، رر، رر،
+
+213
+00:20:03,560 --> 00:20:04,400
+رر، رر، رر، رر، رر، رر، رر، رر، رر، رر، رر، رر،
+
+214
+00:20:04,400 --> 00:20:04,400
+رر، رر، رر، رر، رر، رر، رر، رر، رر، رر، رر، رر،
+
+215
+00:20:04,400 --> 00:20:04,420
+رر، رر، رر، رر، رر، رر، رر، رر، رر، رر، رر، رر،
+
+216
+00:20:04,420 --> 00:20:14,220
+رر، رر، رر، رر، رر،
+
+217
+00:20:14,220 --> 00:20:19,680
+ررلو واحد career، آسف، لو واحد مصاب مع الـ
+
+218
+00:20:19,680 --> 00:20:24,520
+Completely Normal كان كل الأولاد راح يطلعوا
+
+219
+00:20:24,520 --> 00:20:29,240
+Unaffected Careers لو capital R، capital R، بس
+
+220
+00:20:29,240 --> 00:20:34,120
+بهذا الشكل بنشوف الواحد إنها بتكون بهذه الطريقة في
+
+221
+00:20:34,120 --> 00:20:38,880
+حالة ما إنه اتنين مصابين اتزوجوا، small R، small
+
+222
+00:20:38,880 --> 00:20:43,360
+R، راح يطلع كلهم affectedويعني الفكرة اللي بده
+
+223
+00:20:43,360 --> 00:20:49,580
+الواحد يفرجيها أول شيء إنه مافيش فرق بين الذكور
+
+224
+00:20:49,580 --> 00:20:53,160
+والإناث يعني في الحالة هذه، في أي ناحية مهمة
+
+225
+00:20:53,160 --> 00:20:58,060
+والشغل الثاني، في الـPossibilities يعني لازم
+
+226
+00:20:58,060 --> 00:21:02,780
+الواحد حتى يجيب الاحتمالية بشكل دقيق لازم يكون
+
+227
+00:21:02,780 --> 00:21:08,060
+يعرف هل هوبما أنه Recessive ففيه بالنسبة للإنسان
+
+228
+00:21:08,060 --> 00:21:13,640
+اللي مش مصاب فيه possibility إنه يكون يا إما يعني
+
+229
+00:21:13,640 --> 00:21:20,900
+dominant الإثنين، two copies وبالتالي ما عندهوش ما
+
+230
+00:21:20,900 --> 00:21:26,440
+عندهوش جين مصاب أو بيكون Carrier فهذه اللي بتفرق
+
+231
+00:21:26,440 --> 00:21:30,400
+اللي ليه المجهول تحيانًا من ناحية الـ Genotype و
+
+232
+00:21:30,400 --> 00:21:35,430
+الـ Phenotype أيوة كريم، أحكي ده شو Endedفي حد رفع
+
+233
+00:21:35,430 --> 00:21:40,950
+إيده؟ في
+
+234
+00:21:40,950 --> 00:21:46,630
+أسئلة؟ أنا تمام، يا عزيزي يا دكتور الله عفوا،
+
+235
+00:21:46,630 --> 00:21:51,710
+عشوية، يمكن نتفضل الحالة الأولى، اللي فوق الـ
+
+236
+00:21:51,710 --> 00:21:56,130
+Career الـ «أر كبتر، أر صغير، و أر كبتر، أر صغير»
+
+237
+00:21:56,130 --> 00:22:02,310
+هي نسبة غالبينها بإنه «أتا» مش مصابين «unaffected»
+
+238
+00:22:02,310 --> 00:22:07,250
+نعمل، وواحد تبقى «affected»ولّا لازم نذكر أنه… ما
+
+239
+00:22:07,250 --> 00:22:15,110
+فهمت عليك السؤال ما فهمت
+
+240
+00:22:15,110 --> 00:22:21,870
+السؤال لسه، عيد السؤال الحالة الأولى، ما لها؟
+
+241
+00:22:21,870 --> 00:22:26,310
+هلجيت؟ لما كنا ندرس ال «Genetics» قبل أيام
+
+242
+00:22:26,310 --> 00:22:30,270
+المدرسة، كنا ناخد إن اللي فوق يكون مثلا 525، تلاتة
+
+243
+00:22:30,270 --> 00:22:34,140
+لواحدلكن هاد أنت الـ «unaffected carriers»
+
+244
+00:22:34,140 --> 00:22:38,100
+بنعتبرها لحظة مثلا في النسبة اللي قدام في الأسئلة
+
+245
+00:22:38,100 --> 00:22:41,040
+أو في الاختبارات لازم نحكي أن الـ «unaffected
+
+246
+00:22:41,040 --> 00:22:44,980
+carrier» نص والـ «unaffected» لحالها ربيع والـ
+
+247
+00:22:44,980 --> 00:22:49,640
+«unaffected» لحالها ربيع ولكن أنت اللي فوق مع بعض
+
+248
+00:22:49,640 --> 00:22:57,520
+لأ إذا في سؤال طالب بشكل تفصيلي يعني أنت هنا مهين
+
+249
+00:22:57,520 --> 00:23:05,400
+بيني ربعو3.5% unaffected يعني الـ «unaffected» 75%
+
+250
+00:23:05,400 --> 00:23:10,260
+والـ «affected» دلوقت بس
+
+251
+00:23:10,260 --> 00:23:16,180
+الفكرة يعني في ملاحظة اللي هي إنك أنت لو ما نقول
+
+252
+00:23:16,180 --> 00:23:21,250
+مثلا و الله احتمالية تجيب الحامل ولد ولا بنت نصمش
+
+253
+00:23:21,250 --> 00:23:26,330
+بالضرورة إنه لو جابت أربعة من قبل الذكور الأخيرة
+
+254
+00:23:26,330 --> 00:23:31,310
+لازم تطلع أنت أو ممكن تطلع كذا يعني شو الإنسان
+
+255
+00:23:31,310 --> 00:23:35,930
+بيطلع مدى ما فيه احتمالية ربع، عشر، كذا يمكن هذا
+
+256
+00:23:35,930 --> 00:23:40,210
+الاحتمال يتطلع كل مرة يعني ممكن يصير يعني فهي هذه
+
+257
+00:23:40,210 --> 00:23:45,410
+النقطة أما الأرقام اللي موجودة بهذا الشكل آه لازم
+
+258
+00:23:45,410 --> 00:23:49,850
+تعرفها بهذا الشكل إذا أنا سألتك كام Uneffective في
+
+259
+00:23:49,850 --> 00:23:56,090
+الحالة الأولىبدّك تقول ليه 75%؟ لأنه النص والرفاق
+
+260
+00:23:56,090 --> 00:24:00,610
+75% أنا
+
+261
+00:24:00,610 --> 00:24:04,750
+مش مستيقظ، يا دكتور نعم، يعني شغلكم في المدارس كان
+
+262
+00:24:04,750 --> 00:24:10,450
+صحيح بس التفصيل،
+
+263
+00:24:10,450 --> 00:24:15,070
+إذا عند الواحد قالي تدرس الجينات ويعرف إنه هل
+
+264
+00:24:15,070 --> 00:24:20,170
+الـCareer اللي أمامه Career ولا Completely Normal
+
+265
+00:24:20,770 --> 00:24:27,630
+ماشي، هاي بدك يكون الواحد من تباهي لها فالإحتمالات
+
+266
+00:24:27,630 --> 00:24:32,370
+في الجداول هذه هي للـ Autosomal Recessive Diseases
+
+267
+00:24:32,370 --> 00:24:37,270
+ماشي، و الفكرة الأساسية فيها زي ما فرجينا هنا بالـ
+
+268
+00:24:37,270 --> 00:24:42,010
+Pedigree هذا إن الذكور والإناف متساوين، يعني من
+
+269
+00:24:42,010 --> 00:24:48,220
+ناحية احتماليةالقدرة على حمل الجين الموروث التبع
+
+270
+00:24:48,220 --> 00:24:57,760
+المرض وبكونه affected بشكل متشابه ماشي، لما نكون،
+
+271
+00:24:57,760 --> 00:25:04,060
+يعني ناحية مهمة كثير لما نتكلم على إنه Autism and
+
+272
+00:25:04,060 --> 00:25:10,080
+Recessive قضية الـ Consanguinity الـ Consanguinity
+
+273
+00:25:10,080 --> 00:25:19,440
+من أهم الظواهربصراحة في دول ثانية مثلًا
+
+274
+00:25:19,440 --> 00:25:25,680
+عند الروس الناس بسمع عنهم بشكل معين الروس بنت العم
+
+275
+00:25:25,680 --> 00:25:31,600
+وبنت الخال والأقارب بهذا الدرجة بالنسبة إنا زي
+
+276
+00:25:31,600 --> 00:25:37,080
+الأخر يعني ما بيفكر واحد منهم يتزوج بنت عمه وبنت
+
+277
+00:25:37,080 --> 00:25:41,500
+خاله بهذا الدرجة يعني إذا بدى يتزوج بيبعد كتير
+
+278
+00:25:41,500 --> 00:25:47,880
+كتيرفيعني حتى في ثقافات معينة قضية زواج الأقارب
+
+279
+00:25:47,880 --> 00:25:52,820
+ودرجتها يعني بتلاقيهم بيبعدوا أكثر بكثير منها
+
+280
+00:25:52,820 --> 00:25:58,360
+وعندهم يعني زواج الأقارب درجة ولاد العم وابنانات
+
+281
+00:25:58,360 --> 00:26:03,760
+العم لأ غير مقبول يعني، مع أنه يعني الواحد مننا
+
+282
+00:26:03,760 --> 00:26:09,420
+بعرف قصص ولاد سيدنا آدم عليه السلام أول ما بدهكان
+
+283
+00:26:09,420 --> 00:26:14,360
+الأخ يوخد أخته يعني من بطن ثاني يعني لما كانوا
+
+284
+00:26:14,360 --> 00:26:22,000
+يجيبوا في بداية البشرية يعني فقضية الـ
+
+285
+00:26:22,000 --> 00:26:29,440
+Consanguinity قضية مهمة وبتأشر على الـ Autosomal
+
+286
+00:26:29,440 --> 00:26:34,180
+Recessive Inheritance والسبب إنه الـ Carriers
+
+287
+00:26:34,180 --> 00:26:39,760
+أحياناً بتكون احتماليتها في المجتمع قليلةبحيث إذا
+
+288
+00:26:39,760 --> 00:26:45,000
+ما كان زواج أقارب وكذا بيصير احتمالية إن اثنين
+
+289
+00:26:45,000 --> 00:26:51,500
+careers يتجوزوا بعض بتكون احتمالية نادرة فهي برضه
+
+290
+00:26:51,500 --> 00:26:56,780
+بتعطينا مثال على «Autosomal Recessive Inheritance»
+
+291
+00:26:56,780 --> 00:27:02,340
+راح ناخد بعدين أمثل على شو يعني بعض الأمثل في
+
+292
+00:27:02,340 --> 00:27:11,120
+الأشياء التانية والفكرة أنه الـيعني الـ autosomal
+
+293
+00:27:11,120 --> 00:27:15,520
+بتكون الذكر والأنثى زي بعض لما ناخد الـ autosomal
+
+294
+00:27:15,520 --> 00:27:22,180
+dominant inheritance اللي هي بتكون على العكس وجود
+
+295
+00:27:22,180 --> 00:27:27,040
+one copy of the disease is enough to manifest the
+
+296
+00:27:27,040 --> 00:27:34,020
+disease لأن هو dominant، ماشي، فإذا أخدنا شخص مصاب
+
+297
+00:27:34,790 --> 00:27:41,970
+اللي هو في الحالة هذه D-Capital وD-Small بيكون
+
+298
+00:27:41,970 --> 00:27:47,650
+الجنيد استبعاته D-Capital في نص صمم وD-Small في نص
+
+299
+00:27:47,650 --> 00:27:56,680
+تاني ويزوج مع شخص آخر أو معتزوج أخرى زوجته «small
+
+300
+00:27:56,680 --> 00:28:01,720
+capital» «small D» «small D» بهذا الشكل راح ينتج
+
+301
+00:28:01,720 --> 00:28:08,460
+عنه إنه نص الأطفال مصابين ونص الأطفال غير مصابين
+
+302
+00:28:08,460 --> 00:28:15,120
+لما أشوف أنا هذه النسب وفي الحالة هذه بتكون الذكور
+
+303
+00:28:15,120 --> 00:28:22,840
+والإناث زي بعض مافي أي تأثير للجنس على القضية هذه
+
+304
+00:28:24,440 --> 00:28:30,940
+فهذه في حالة إذا مصاب اتزوج إنسان طبيعي الطبيعي
+
+305
+00:28:30,940 --> 00:28:44,620
+لازم يكون Dd في حالة إثنين مصابين ويكون عندهم Dd
+
+306
+00:28:44,620 --> 00:28:49,800
+بهذا الشكل، يكون الـ Genotype تبعهم، في الحالة هذه
+
+307
+00:28:50,660 --> 00:28:58,380
+إذا كان زواج بهذه الطريقة بالنسبة لما نكون
+
+308
+00:28:58,380 --> 00:29:04,380
+strictly dominant يعني قضية
+
+309
+00:29:04,380 --> 00:29:12,460
+أنه أحيانًا الـ dominance يعني مش ظاهرة دائمًا 100
+
+310
+00:29:12,460 --> 00:29:19,420
+% يعني مثلًا لما نيجي مثلك تختار بالي على طول قضية
+
+311
+00:29:19,420 --> 00:29:26,350
+الصلاعةفيه جينات معينة لما تكون عند الرجال بيكون
+
+312
+00:29:26,350 --> 00:29:31,190
+عندهم جين الصلاة على طول بيبين لو كان يعني بيصير
+
+313
+00:29:31,190 --> 00:29:36,730
+dominant بينما نفسه نفسه في الـ Female، Recessive
+
+314
+00:29:36,730 --> 00:29:41,070
+في حيث أنه بتلاقي بالـ Female بدك Two doses من الـ
+
+315
+00:29:41,070 --> 00:29:45,610
+Disease جين حتى يبين صلاة بشكل درجة أقل من الرجل
+
+316
+00:29:45,610 --> 00:29:51,360
+فاحياناً في عوامل أخرى بتتدخل فيهافإذا هنا افترضنا
+
+317
+00:29:51,360 --> 00:29:57,940
+Strictly Dominant يعني بظاهر
+
+318
+00:29:57,940 --> 00:30:01,680
+بشكل قوي جداً وبتكفي نسقة واحدة تعطينا المرض
+
+319
+00:30:01,680 --> 00:30:06,760
+وانتهينا فراح يصير عندي إنه تلت ارباع من
+
+320
+00:30:06,760 --> 00:30:13,660
+الـAffected راح يكونوا Affected سواء دي دي بالربع
+
+321
+00:30:13,660 --> 00:30:22,130
+أو D بالنصاللي هم هذولة المجموعة وبكون الربع
+
+322
+00:30:22,130 --> 00:30:25,110
+«unaffected» «small d» «small d» يعني بيظل فيه
+
+323
+00:30:25,110 --> 00:30:31,050
+احتمال إنه يطلع من أبنعهم وبناتهم إنسان ماعندهوش
+
+324
+00:30:31,050 --> 00:30:35,450
+المرض في حالة ما بيكون «incompletely dominant»
+
+325
+00:30:35,450 --> 00:30:43,590
+يعني بتصير إنه الـ «D» «D» بفرف عن الـ «D» «d»
+
+326
+00:30:43,590 --> 00:30:49,650
+فبصيرالربع الـ Severely Affected ونُص الـ Affected
+
+327
+00:30:49,650 --> 00:30:55,190
+بس الرُبع الـ Unaffected بيكون هاته التقصيمات وهذا
+
+328
+00:30:55,190 --> 00:31:02,010
+يعني على افتراض أن الـ Capital D هي المُصاب والـ
+
+329
+00:31:02,010 --> 00:31:07,230
+Small D هي الـ Normal اللي مش مُصاب على أساس أن
+
+330
+00:31:07,230 --> 00:31:12,550
+الـ Disease Gene الـD Capital هو الـ Dominant ومرة
+
+331
+00:31:12,550 --> 00:31:17,180
+أختلفةبحكي إنه هو نقطة «zomel» يعني ما راح يكون
+
+332
+00:31:17,180 --> 00:31:20,980
+فيه فرق بين ولاد وبنات أو بين دكور وإنات بالنسبة
+
+333
+00:31:20,980 --> 00:31:26,180
+للـ Disease هذا فهذه ناحية مهمة وإذا الواحد بيشوف
+
+334
+00:31:26,180 --> 00:31:36,000
+حالات مثل هذه بيلاقي الواحد أنه النقطة الأساسية
+
+335
+00:31:36,000 --> 00:31:43,990
+اللي بنصف فيها الـ «zomel dominant» أنهفيه ذكور
+
+336
+00:31:43,990 --> 00:31:48,830
+وفيه إنات مصابين وفيه ذكور وفيه إنات مش مصابين
+
+337
+00:31:48,830 --> 00:31:54,830
+يعني مافيش اختيار لجنس معين يعني هاي فيه أم مصابة
+
+338
+00:31:54,830 --> 00:32:00,710
+أعطت ولادين وبنت إلها وبعدين ولادها وبناتها لما
+
+339
+00:32:00,710 --> 00:32:06,130
+اتزوجوا في بعضهم ماسواش مشكلة أو في بعض الأبناء
+
+340
+00:32:06,130 --> 00:32:10,530
+لأخرين ماكانش عندهم أي مشكلة بينما فيه أكتر من شخص
+
+341
+00:32:10,530 --> 00:32:17,180
+في العائلةالملاحظة فيها، اللي هي قضية إنه مافيش
+
+342
+00:32:17,180 --> 00:32:24,900
+skip generation يعني مافيش إنه فيه جيل مصاب وجيل
+
+343
+00:32:24,900 --> 00:32:29,040
+مش مصاب جيل مصاب وجيل مش مصاب يعني قضية إنه ما
+
+344
+00:32:29,040 --> 00:32:35,900
+يعني لما أخذنا بالـبالـ Autosome Recessive بتلاقي
+
+345
+00:32:35,900 --> 00:32:40,440
+إنه عقلي مثلا ماعندهاش ولا شخص مصاب أبدا وبيطلع في
+
+346
+00:32:40,440 --> 00:32:45,720
+عندهم شخص مصاب السبب بيكون إنه اثنين Carriers والـ
+
+347
+00:32:45,720 --> 00:32:50,920
+Carrier ما بيظهر عليه إشي فبالتالي بيبين في المصاب
+
+348
+00:32:50,920 --> 00:32:53,600
+لما يكون الـ Autosome الـ dominant بدي يكون صورته
+
+349
+00:32:53,600 --> 00:33:06,820
+زي هي أحياناً يعني إذا بالذات فييعني هنا الشخصين
+
+350
+00:33:06,820 --> 00:33:13,920
+مصابين بحالة معينة ولسبب ما اتزوجوا ماشي هنا بديوا
+
+351
+00:33:13,920 --> 00:33:18,660
+يكونوا capital D، small D لأنه فيه بنت هنا مش
+
+352
+00:33:18,660 --> 00:33:24,440
+مصابة والإصابة شديدة لحظة إنه شخص من المصابين
+
+353
+00:33:24,440 --> 00:33:30,520
+اتوفى وهذه مثلا في حالة معينة وأحياناً
+
+354
+00:33:32,980 --> 00:33:41,960
+بالنسبة لإنه يكون الطفرة تبدأ في شخص معين ماشي فيه
+
+355
+00:33:41,960 --> 00:33:46,680
+مثلا الـ Fibroblast Growth Factor Receptor 3 بيصير
+
+356
+00:33:46,680 --> 00:33:52,200
+اندي أرجينين في الـ position هذا اللي هو 248 على
+
+357
+00:33:52,200 --> 00:33:58,690
+بروتين معيناللي هو مستقبل الـFibroblast Growth
+
+358
+00:33:58,690 --> 00:34:04,870
+Factor بتحول لـ16 وبالتالي بتخرج وظيفته بيصير عندي
+
+359
+00:34:04,870 --> 00:34:11,490
+Mutation في حالة زي هذه فدولة أمثلة على
+
+360
+00:34:11,490 --> 00:34:18,570
+الـAutosomal Dominant Inheritance
+
+361
+00:34:19,040 --> 00:34:22,980
+فهنا المثال اللي حاطين عليه Adult-onset
+
+362
+00:34:22,980 --> 00:34:27,540
+progressive sensorineuronal deafness inherited as
+
+363
+00:34:27,540 --> 00:34:29,440
+a metazomic dominant trait
+
+364
+00:34:32,870 --> 00:34:37,970
+فهذه الحالة الأولى حاطينها إنه درسوا عائلة معينة
+
+365
+00:34:37,970 --> 00:34:44,390
+فيه بيصير عندهم deafness بسبب، يعني مش خلل توصيلي
+
+366
+00:34:44,390 --> 00:34:49,610
+بالسمع إنما خلل عصبي، من عصب السمع اللي فيه مشكلة
+
+367
+00:34:49,610 --> 00:34:58,330
+الثانية حالة أكندربلازيا، راح نقض عنها والثالثة،
+
+368
+00:34:58,330 --> 00:35:01,650
+شو اسمه؟ يعني
+
+369
+00:35:03,380 --> 00:35:08,680
+تاناتروبيك دوارفزم، نوعية معينة جينيتيكية «Lethal
+
+370
+00:35:08,680 --> 00:35:15,220
+in the Proband» كانت فيه إصابة شديدة بحيث أنه كانت
+
+371
+00:35:15,220 --> 00:35:19,140
+مع أنه لو حطوا أنه «Lethal» كان المفروض يحطوا
+
+372
+00:35:19,140 --> 00:35:24,900
+الإشارة هذه يعني هنا الـ «Proband» مش معطين الكلام
+
+373
+00:35:24,900 --> 00:35:30,300
+شويه مختلف عن التفسير يعني الـ «Proband» اللي
+
+374
+00:35:30,300 --> 00:35:34,530
+بيحطوا عليهالسهم هذا اللي هي الحالة اللي خلتهم
+
+375
+00:35:34,530 --> 00:35:40,550
+يدرسوا الموضوع ولمّا يحطوا بهذا الشكل على دائرة أو
+
+376
+00:35:40,550 --> 00:35:45,850
+على مربع معناته هذا إنسان اتوفى فهذولا بـ degrees
+
+377
+00:35:45,850 --> 00:35:52,770
+لأشياء autosomal dominant high mal-limited
+
+378
+00:35:52,770 --> 00:35:58,630
+precocious purity الـ X-limited autosomal dominant
+
+379
+00:35:58,630 --> 00:36:03,750
+disorderيعني هي مثال على زي حكاية الصلع اللي
+
+380
+00:36:03,750 --> 00:36:15,490
+حكيتها قبل شوية بقضية إن الـ Pedigree يعني بتكون
+
+381
+00:36:15,490 --> 00:36:21,970
+صحيح هو يعني autosomal، dominantبالنسبة لـ… يعني
+
+382
+00:36:21,970 --> 00:36:26,650
+هو الـ «جين» اللي فيه المشكلة من الـ «أوتوزامال
+
+383
+00:36:26,650 --> 00:36:30,910
+جين» أو الـ «أوتوزامال كرومازون» «أوتوزامال
+
+384
+00:36:30,910 --> 00:36:30,910
+كرومازون» «أوتوزامال كرومازون» «أوتوزامال
+
+385
+00:36:30,910 --> 00:36:30,910
+كرومازون» «أوتوزامال كرومازون» «أوتوزامال
+
+386
+00:36:30,910 --> 00:36:30,910
+كرومازون» «أوتوزامال كرومازون» «أوتوزامال
+
+387
+00:36:30,910 --> 00:36:31,010
+كرومازون» «أوتوزامال كرومازون» «أوتوزامال
+
+388
+00:36:31,010 --> 00:36:33,490
+كرومازون» «أوتوزامال كرومازون» «أوتوزامال
+
+389
+00:36:33,490 --> 00:36:37,730
+كرومازون» «أوتوزامال
+
+390
+00:36:37,730 --> 00:36:42,890
+كرومازون» «أوتوزامال كرومازون» «
+
+391
+00:36:51,420 --> 00:36:55,600
+ليش ليس X-linked recessive بعدها؟ ميه بيقدر
+
+392
+00:36:55,600 --> 00:36:58,840
+يفسرني؟
+
+393
+00:36:58,840 --> 00:37:05,320
+في حدا منتبه على شو اللي … شو اللي عم بيصير هنا في
+
+394
+00:37:05,320 --> 00:37:10,140
+هذه العيلة؟
+
+395
+00:37:10,140 --> 00:37:14,720
+الآن
+
+396
+00:37:14,720 --> 00:37:17,220
+الـ X-linked recessive
+
+397
+00:37:19,600 --> 00:37:26,420
+بكون القضية أنه «mail-to-mail transmission» ما
+
+398
+00:37:26,420 --> 00:37:33,460
+بتصير يعني الـ «ex-linked recessive» إيه جواب كان
+
+399
+00:37:33,460 --> 00:37:38,900
+من دكتورة نادية بتقول إنه انتقل المرض من ذكر لذكر؟
+
+400
+00:37:38,900 --> 00:37:43,840
+آه صحيحيعني إحنا في العائلة اللي بيكون فيها Ex
+
+401
+00:37:43,840 --> 00:37:48,740
+-linked recessive فضية اللي هي بيكون المصاب هو
+
+402
+00:37:48,740 --> 00:37:54,820
+الطفل أو الولد الذكر المصاب وبتروح، بتدور، تسأل عن
+
+403
+00:37:54,820 --> 00:37:59,020
+أخواله وبتلاقي في حد في عنده مصابة والسبب إن
+
+404
+00:37:59,020 --> 00:38:05,420
+الـFemales بيكونوا Carriers بينما هنا في ملاحظة
+
+405
+00:38:05,420 --> 00:38:11,170
+إنه مافيش Female مصابةوهذا against أن تكون
+
+406
+00:38:11,170 --> 00:38:14,390
+autosomal
+
+407
+00:38:14,390 --> 00:38:18,490
+يعني حكينا لما تكون شغلة autosomal الأصل يكون
+
+408
+00:38:18,490 --> 00:38:22,450
+males و females قط بعض أو في إمكانية يحدث للإثنين
+
+409
+00:38:22,450 --> 00:38:29,010
+أن يكون males و females فهذه ثلاث أجيال في عائلة
+
+410
+00:38:29,010 --> 00:38:36,940
+معينة ونلاقي إن المصابين فقط هم الـ malesماشي، هاي
+
+411
+00:38:36,940 --> 00:38:42,960
+أثنين أخوين مصابين هذا الأخ يعني أحد الإخوة جاب
+
+412
+00:38:42,960 --> 00:38:47,400
+أعطى لأولاده
+
+413
+00:38:47,400 --> 00:38:52,760
+الأثنين وبعدين بنته أعطت لحفيده يعني هو أعطى
+
+414
+00:38:52,760 --> 00:38:56,780
+أولاده مباشرة وهاي الـ females أعطوا بالأخير ل
+
+415
+00:38:56,780 --> 00:39:04,540
+males فهي هنا يعني الوراثة بهذا الشكل، ماشي
+
+416
+00:39:04,950 --> 00:39:10,250
+بتخلّينا نشترك، نشك أنه آه والله كان ممكن يكون X
+
+417
+00:39:10,250 --> 00:39:15,130
+-linked recessive بس الحقيقة أنه الـ X-linked
+
+418
+00:39:15,130 --> 00:39:19,130
+recessive مافي male to male direct inheritance
+
+419
+00:39:19,130 --> 00:39:23,570
+فوجود الـ male to male direct inheritance بيخليني
+
+420
+00:39:23,570 --> 00:39:28,490
+أقول هذا أوتزومل مش X-linked فمش من خلال الـ الـ
+
+421
+00:39:28,490 --> 00:39:35,920
+الـ female carrier وبالتاليبيكون فيه إنه المصاب هو
+
+422
+00:39:35,920 --> 00:39:42,040
+واخوانه بيكون فيهم مصابين بهذه الطريقة فهي يعني
+
+423
+00:39:42,040 --> 00:39:49,900
+one of the variations in أوتزومال dominant بس
+
+424
+00:39:49,900 --> 00:39:57,400
+affected bisex ماشي يعني هذه احتمالية بتكون موجودة
+
+425
+00:39:57,400 --> 00:40:05,410
+وبتكون في بعض الحلالفي أمراض الـ Autosomal
+
+426
+00:40:05,410 --> 00:40:12,290
+dominant trait اللي هي خلل في الـ الـ hands و الـ
+
+427
+00:40:12,290 --> 00:40:19,930
+feet Split hand deformity بهذا الشكل، ماشي يعني
+
+428
+00:40:19,930 --> 00:40:23,430
+عبارة عن الـ congenital anomaly of the hands and
+
+429
+00:40:23,430 --> 00:40:30,430
+feet لما نشوف زي هيك هاي female و هدولة females
+
+430
+00:40:30,430 --> 00:40:36,530
+affectedوبعدين هذا الـ Male أيضًا يتأثر، ماشي فلما
+
+431
+00:40:36,530 --> 00:40:41,210
+يكون حاجة زي هيك بديها تكون أن هذا Autosomal
+
+432
+00:40:41,210 --> 00:40:47,090
+dominant، ماشي لأنه مافيش skip generation، فيه
+
+433
+00:40:47,090 --> 00:40:53,450
+إصابة بكوره إناف وكل ال generations فيهم إصابات،
+
+434
+00:40:53,450 --> 00:40:59,430
+يعني ال .. هو أنا .. يعني ممكن لو ال ..النصاب
+
+435
+00:40:59,430 --> 00:41:03,450
+الأولى كان عندها ولاد وبنات أكثر كان ممكن يبين
+
+436
+00:41:03,450 --> 00:41:10,710
+أكتر مع ولاد مش إنات يعني فأي بالنسبة للـ
+
+437
+00:41:10,710 --> 00:41:13,750
+Autosomal Dominant Inheritance بيكون بهذا الشكل
+
+438
+00:41:13,750 --> 00:41:23,610
+بالنسبة للـ X-Linked Diseases، ماشي فهنا بيصير فيه
+
+439
+00:41:23,610 --> 00:41:30,700
+فرق كبير بين الـ males و ال femalesوكمان يعني عشان
+
+440
+00:41:30,700 --> 00:41:35,960
+واحد يكون دقيق في المصطلح الـ Males ماحنا لازم
+
+441
+00:41:35,960 --> 00:41:43,560
+بيكون عندنا one copy of X-chromosome فالـ Males
+
+442
+00:41:43,560 --> 00:41:51,300
+بنسميهم Hemizygous capital H للـ X-chromosome أو
+
+443
+00:41:51,300 --> 00:41:58,340
+Hemizygous small letterطبعًا الـ «H» كابيتال
+
+444
+00:41:58,340 --> 00:42:03,480
+بالنسبة في الحالة هذه على الـ X-Chromosome
+
+445
+00:42:03,480 --> 00:42:08,780
+«unaffected» هذا الجين الطبيعي الجين المصاد «small
+
+446
+00:42:08,780 --> 00:42:18,740
+letter»، ناشي؟ فبالنسبة للـ «Homo» و«Heterozygous»
+
+447
+00:42:18,740 --> 00:42:22,790
+اللي هي لما نكون في عنا Two copies من الجينهل هما
+
+448
+00:42:22,790 --> 00:42:29,990
+متشابهات أو مختلفات ‏homozygous يعني اترزاجس
+
+449
+00:42:29,990 --> 00:42:33,170
+يعني اترزاجس يعني اترزاجس يعني اترزاجس يعني
+
+450
+00:42:33,170 --> 00:42:37,090
+اترزاجس يعني اترزاجس يعني اترزاجس يعني اترزاجس
+
+451
+00:42:37,090 --> 00:42:37,730
+يعني اترزاجس يعني اترزاجس يعني اترزاجس يعني
+
+452
+00:42:37,730 --> 00:42:37,730
+اترزاجس يعني اترزاجس يعني اترزاجس يعني اترزاجس
+
+453
+00:42:37,730 --> 00:42:37,730
+يعني اترزاجس يعني اترزاجس يعني اترزاجس يعني
+
+454
+00:42:37,730 --> 00:42:37,750
+اترزاجس يعني اترزاجس يعني اترزاجس يعني اترزاجس
+
+455
+00:42:37,750 --> 00:42:48,770
+يعني اترزاجس يعني اترزاجس يعني اترزاجس يعني ا
+
+456
+00:42:48,930 --> 00:42:55,670
+هل هو Unaffected أو Affected وبكون الـ «H» بيكون
+
+457
+00:42:55,670 --> 00:43:02,270
+Normal والـ «h» بيكون مصاب الـ «فيميلز» فيه أكثر
+
+458
+00:43:02,270 --> 00:43:09,190
+من احتمال قضية الاحتمال الأول «Homozygous
+
+459
+00:43:09,190 --> 00:43:17,570
+Unaffected» اللي هي الأنثى الطبيعيةالـ X2 copies
+
+460
+00:43:17,570 --> 00:43:23,170
+of X-chromosomes عليهم كابيتال لتر Unaffected gene
+
+461
+00:43:23,170 --> 00:43:30,290
+أو الـ Allele is not affected الـ Heterozygous فيه
+
+462
+00:43:30,290 --> 00:43:34,790
+برضه Two X-chromosomes فيه كابيتال H و Small H
+
+463
+00:43:34,790 --> 00:43:42,240
+فهذه Carrier ماشيcarrier may not أو may or may not
+
+464
+00:43:42,240 --> 00:43:49,940
+be affected الأصل إذا X-linked recessive ماشي، X
+
+465
+00:43:49,940 --> 00:43:53,360
+-linked recessive فهتكون carrier بمعنى not
+
+466
+00:43:53,360 --> 00:43:58,220
+affected بس إذا راح نحكي ممكن يكون X-linked
+
+467
+00:43:58,220 --> 00:44:01,440
+dominant
+
+468
+00:44:01,440 --> 00:44:07,040
+ممكن يكون هذا احتمال وحكينا عن احتمال ثالث اللي هو
+
+469
+00:44:07,450 --> 00:44:11,670
+في قضية الـ Ionization أو القضية الـ Inactivation
+
+470
+00:44:11,670 --> 00:44:16,030
+of the X-Chromosomes إنه أحيانًا بشكل عشوائي، يا
+
+471
+00:44:16,030 --> 00:44:19,710
+هاي الـ Copy يا هاي الـ Copy بتكون Inactive وما
+
+472
+00:44:19,710 --> 00:44:23,790
+بتشتغلش، ففي الحالة هذه راح يكون إذا الـ Active
+
+473
+00:44:23,790 --> 00:44:28,470
+Form والـ Small H راح يكون عندها إصابة which can
+
+474
+00:44:28,470 --> 00:44:32,450
+be affected الـ Homozygous أو الـ Compound
+
+475
+00:44:32,450 --> 00:44:37,960
+Heterozygous أحيانًاالـ homozygous اللي هو إنه
+
+476
+00:44:37,960 --> 00:44:45,280
+بيكون إنسان «أفكترد» الـ capital «h» و «h» فهي
+
+477
+00:44:45,280 --> 00:44:51,240
+بدنا نسميها homozygous مثلًا،
+
+478
+00:44:51,240 --> 00:44:58,860
+بلاقي أنا عندي جين بعطي بروتين حوالي مثلًا ألف
+
+479
+00:44:58,860 --> 00:45:06,410
+amino acid نفترض أيه أحيانًافيه كثير من الأمراض زي
+
+480
+00:45:06,410 --> 00:45:11,130
+الـ Familial Mediterranean Fever أو الـ Cystic
+
+481
+00:45:11,130 --> 00:45:18,070
+Fibrosis أو كذا، الجين كبير فأحياناً
+
+482
+00:45:18,070 --> 00:45:24,270
+القُبية الأولى مضروبة مثلاً في الـ Amino Acid رقم
+
+483
+00:45:24,270 --> 00:45:31,550
+100 والثانية مضروبة بس في محل ثاني فلما نكون زي
+
+484
+00:45:31,550 --> 00:45:36,190
+هيكأنا بسميه compound heterozygous لأن الـ
+
+485
+00:45:36,190 --> 00:45:43,110
+mutation مش متشابهة يعني مش Small X Small H تماماً
+
+486
+00:45:43,110 --> 00:45:48,510
+لأ عبارة عن إصابتين بس لما إنهم في مكانين مختلفين
+
+487
+00:45:48,510 --> 00:45:53,630
+بس كل نسخة مصابة يعني مش يعني مش نسخة مصابة في
+
+488
+00:45:53,630 --> 00:45:59,160
+مكانين أحياناً هي ممكنة يعني الـ FMFفميليا الـ
+
+489
+00:45:59,160 --> 00:46:03,920
+Mediterranean fever «أم البحر الأبيض المتوسط» الـ
+
+490
+00:46:03,920 --> 00:46:07,760
+Pyrene اللي هو البروتين اللي بيصير عليه الإشكالية
+
+491
+00:46:07,760 --> 00:46:15,260
+تقريبًا ألف أمينو أسد وفي حوالي أتناشر بيسموه الـ
+
+492
+00:46:15,260 --> 00:46:19,920
+Egg Zones دولة القطع اللي لازم يشبكن بعضها ففي الـ
+
+493
+00:46:19,920 --> 00:46:24,440
+Egg Zone رقم 2 والـ Egg Zone رقم 10 بيكون عليهم
+
+494
+00:46:24,440 --> 00:46:33,260
+الضربات فإذا عندي أناتو مقاطعين كل واحدة مضروبة
+
+495
+00:46:33,260 --> 00:46:39,280
+بجهة ثانية مختلفة راح يسببني مرض قريب من أن يكون
+
+496
+00:46:39,280 --> 00:46:47,000
+الـ homozygous كامل يعني اللي هو زي الـ small h
+
+497
+00:46:47,000 --> 00:46:53,020
+small h إذا كان كامل أو إذا في ممكن من شيء بيبقى
+
+498
+00:46:53,020 --> 00:46:58,440
+نقوله compound heterozygous إن الـ two copiesكل
+
+499
+00:46:58,440 --> 00:47:03,620
+واحدة مضروبة في محل مختلف واضحة فيها سلة
+
+500
+00:47:06,800 --> 00:47:13,580
+الـ High يعني النقطة الأساسية بالنسبة للـ X-linked
+
+501
+00:47:13,580 --> 00:47:18,080
+disease قضية الواحد يتذكر إن الـ Male ما عندهوش
+
+502
+00:47:18,080 --> 00:47:22,160
+غير نسخة واحدة وبالتالي هو يجب أن نسميه
+
+503
+00:47:22,160 --> 00:47:27,640
+«Hemizygous» الـ «فيميلز» عندهم Two copies فبتلاقي
+
+504
+00:47:27,640 --> 00:47:31,280
+«Hemizygous» Normal أو «Heterozygous» إذا One copy
+
+505
+00:47:31,280 --> 00:47:35,530
+affected أو «Hemizygous» affected إذا كانأو
+
+506
+00:47:35,530 --> 00:47:45,690
+Compound Heterozygous تذكروا قضية مثلًا Female إذا
+
+507
+00:47:45,690 --> 00:47:50,630
+كانت Turner Syndrome XO Inheritance يعني One Copy
+
+508
+00:47:50,630 --> 00:47:56,170
+Only مافيش عندها Y ولا X تانية تعتبرها Hemozygous
+
+509
+00:47:56,170 --> 00:48:00,650
+وبتصير قريبة من الـ Male يعني لو أجت Female وحاملة
+
+510
+00:48:00,650 --> 00:48:09,610
+موروذ لإشيمعين ممكن يظهر عليها مشكلة وتكون شكلها
+
+511
+00:48:09,610 --> 00:48:13,980
+زي المصابي فيها سؤالة؟في سؤال، يا دكتور، من
+
+512
+00:48:13,980 --> 00:48:18,140
+«كاريم» بيسأل عن الـ… اللي هو الـ…
+
+513
+00:48:18,140 --> 00:48:20,700
+الـ«هيتيروزايجس» «compound heterozygous» اللي
+
+514
+00:48:20,700 --> 00:48:24,580
+بتكون انضربت في مكانين مختلفين، بيقول إيش الفرق
+
+515
+00:48:24,580 --> 00:48:27,260
+بينه وبين اللي بتكون في نفس المكان، على الـ«جين»
+
+516
+00:48:27,260 --> 00:48:31,020
+يعني؟ إيش اللي… لأ، لأ، لأ، اسمع علي، اسمع علي،
+
+517
+00:48:31,020 --> 00:48:39,180
+لما نكون الجين المسؤول عن المرض كبير، ماشي، الآن
+
+518
+00:48:39,180 --> 00:48:49,340
+أنا عند حالةممكن إنسان يكون جين كامل طبيعي والجين
+
+519
+00:48:49,340 --> 00:48:55,720
+الثاني مُصاب في مكانين هذا يعني بدنا نسميه إن فيه
+
+520
+00:48:55,720 --> 00:49:04,240
+أكثر من إصابة بيكون heterozygous بيكون يعني إذا
+
+521
+00:49:04,240 --> 00:49:08,440
+كان X-linked recessive فعلى الأقل عنده نسخة كاملة
+
+522
+00:49:08,440 --> 00:49:14,260
+طبيعية كويسة وبالتالي مافيش مرضأحيانًا بلاقي لما
+
+523
+00:49:14,260 --> 00:49:21,000
+يكون عندي أنواع متعددة من الضربات إذا النسخة
+
+524
+00:49:21,000 --> 00:49:25,700
+الأولى مضروبة في مكان فهي أضعف، مش طبيعية والثانية
+
+525
+00:49:25,700 --> 00:49:31,560
+مضروبة في محل ثاني فاللي راح يصير إنه هذا الإنسان
+
+526
+00:49:31,560 --> 00:49:37,720
+قريب الـ Homozygous مصاب، affected السبب إنه عنده
+
+527
+00:49:37,720 --> 00:49:43,070
+compound heterozygous يعنيهو heterozygous لأنه لم
+
+528
+00:49:43,070 --> 00:49:51,050
+يكنتان زي بعض يعني هنا إذا بدي أرسم لها مثال فأنا
+
+529
+00:49:51,050 --> 00:49:57,690
+هنا مثلا H capital H small وخلّيني أسميها H one وH
+
+530
+00:49:57,690 --> 00:50:07,580
+two small على small فهنا بلاقي X H small oneو XH2
+
+531
+00:50:07,580 --> 00:50:14,320
+يعني واحدة مضروبة في محل فهي مضروبة يعني مسببة
+
+532
+00:50:14,320 --> 00:50:19,220
+لمشكلة أو عاملة مشكلة ومرض والثاني كمان نفس الشيء
+
+533
+00:50:19,220 --> 00:50:25,600
+يعني بالمحصلة هو قريب homozygous ماشي يعني فهو
+
+534
+00:50:25,600 --> 00:50:29,400
+affected في الحالة هذه أنا بدي أسميه compound
+
+535
+00:50:29,400 --> 00:50:36,130
+heterozygousكمباند لأنه أكثر من مكان في نفس الجيل
+
+536
+00:50:36,130 --> 00:50:42,210
+بس مكانين مختلفتين، مختلفين مش في نفس المحل يعني
+
+537
+00:50:42,210 --> 00:50:50,160
+ممكن هذا يأثر بطريقة ما علىشدة المرض،
+
+538
+00:50:50,160 --> 00:50:55,120
+ما أعطانا الشكل للـ Phenotype النهائي يعني إذا
+
+539
+00:50:55,120 --> 00:50:58,200
+الإصابة في المكان رقم 100 غير الإصابة في المكان
+
+540
+00:50:58,200 --> 00:51:04,890
+رقم 600 بتعطيك شكل مختلف من الأمراض يعنيسنأخذ
+
+541
+00:51:04,890 --> 00:51:08,750
+مثلًا الـ Hemoglobin & Pathies في الـ S-Hemoglobin
+
+542
+00:51:08,750 --> 00:51:12,390
+اللي فيه تبع الـ Sickles اللي في محل معين وفي الـ
+
+543
+00:51:12,390 --> 00:51:17,310
+C-Hemoglobin اللي بيكون خلل ثاني في محل ثاني ففيه
+
+544
+00:51:17,310 --> 00:51:22,190
+بيطلع لي حد عنده بيسموه SC-Hemoglobin هذا بيكون
+
+545
+00:51:22,190 --> 00:51:26,710
+نسخة مصابة بالمحل الـ S ونسخة مصابة بالمحل الـ C
+
+546
+00:51:26,710 --> 00:51:31,660
+فهذا بتسميه compound heterozygousيعني في إصابتين
+
+547
+00:51:31,660 --> 00:51:37,600
+بس في محليين مختلفين في نفس الجين فهو ماقدرش أقول
+
+548
+00:51:37,600 --> 00:51:43,320
+عنه homozygous لأنه مش متشابهات ماشي إن شاء الله
+
+549
+00:51:43,320 --> 00:51:49,840
+وضحكت للقضية الآن
+
+550
+00:51:49,840 --> 00:51:56,820
+هنا يعني حاطين أمثلة على الـ Duchenne muscular
+
+551
+00:51:56,820 --> 00:52:03,920
+dystrophyالـ Duchene اللي هو من أمثلة الأمراض الـ
+
+552
+00:52:03,920 --> 00:52:09,040
+X-linked recessive ماشي، فإذا الـ males هما اللي
+
+553
+00:52:09,040 --> 00:52:14,540
+affected ال females هما الـ carriers وقاعدي أنا
+
+554
+00:52:14,540 --> 00:52:22,400
+أدرس اللي هو يعني الـ expression تبع الـ gene يعني
+
+555
+00:52:22,400 --> 00:52:27,340
+الـ gene المضروب هذا بالأخير مسئول عن بروتين معين
+
+556
+00:52:28,030 --> 00:52:33,670
+ولمّا أستخدم الـ Fluorescence Microscopy وأتطلع
+
+557
+00:52:33,670 --> 00:52:39,610
+على الـ Dystrophin Distribution والـ Debris، سأجد
+
+558
+00:52:39,610 --> 00:52:47,410
+مثلًا الإنسان الطبيعي اللي هو الـ A الولد
+
+559
+00:52:47,410 --> 00:52:53,790
+المُصاب، سأجده مثلًا الـ Bوالـ يعني هنا الـ
+
+560
+00:52:53,790 --> 00:52:57,330
+Protein اللازم أو اللي كان مسئوله المفروض يكون
+
+561
+00:52:57,330 --> 00:53:02,430
+موجود حتى تكون عضلاته طبيعية مختفي تماماً والـ C
+
+562
+00:53:02,430 --> 00:53:09,890
+Female Carrier حامل الموروض وبنلاحظ هنا يعني صحيح
+
+563
+00:53:09,890 --> 00:53:16,740
+مظهرياًأحنا حكينا إن هذا عبارة عن متنحي والأصل إذا
+
+564
+00:53:16,740 --> 00:53:21,120
+عندك نسخة واحدة تكون كافية بس بطريقة الدراسة هذه
+
+565
+00:53:21,120 --> 00:53:27,920
+ملاقين إنه فيه ضعف بس مش بدرجة تشدت الـAffected
+
+566
+00:53:27,920 --> 00:53:35,940
+Male ويعني مش الواضح إنه فيه Disease وفيه مرض فهنا
+
+567
+00:53:36,410 --> 00:53:40,770
+يعني هذا مثال على الـ X-linked recessive اللي هو
+
+568
+00:53:40,770 --> 00:53:44,550
+الـ «مسكولر ديستروفي» «مسكولر ديستروفي» «مسكولر
+
+569
+00:53:44,550 --> 00:53:45,250
+ديستروفي» «مسكولر ديستروفي» «مسكولر ديستروفي»
+
+570
+00:53:45,250 --> 00:53:45,570
+«مسكولر ديستروفي» «مسكولر ديستروفي» «مسكولر
+
+571
+00:53:45,570 --> 00:53:46,930
+ديستروفي» «مسكولر ديستروفي» «مسكولر ديستروفي»
+
+572
+00:53:46,930 --> 00:53:49,550
+«مسكولر ديستروفي» «مسكولر ديستروفي» «مسكولر
+
+573
+00:53:49,550 --> 00:53:52,350
+ديستروفي» «مسكولر ديستروفي» «مسكولر ديستروفي»
+
+574
+00:53:52,350 --> 00:54:00,870
+«مسكولر ديستروفي» «مسكولر
+
+575
+00:54:00,870 --> 00:54:07,800
+ديستروفي» «يعني البحث هنا على مستوى البروتين
+
+576
+00:54:07,800 --> 00:54:13,580
+المطلوب تكوينه من الجين تبع الـ Duchene Muscular
+
+577
+00:54:13,580 --> 00:54:21,180
+Dystrophy كنوع شديد من البعث العضلات الـ Duchene
+
+578
+00:54:21,180 --> 00:54:26,780
+راح تأخذوا بعدين يعني من الأمثلة علىيعني أمراض
+
+579
+00:54:26,780 --> 00:54:33,880
+العضلات الشديدة تبدأ بالعمر الصغير، الطفل المولود
+
+580
+00:54:33,880 --> 00:54:38,900
+الجديد بيقدرش يقعد على وقته، بيقدرش يوقف، بيقدرش
+
+581
+00:54:38,900 --> 00:54:43,060
+يبقى متأخر لما يمشي، بيقدرش يقلب لما يكذا، اللي هي
+
+582
+00:54:43,060 --> 00:54:48,780
+الـMilestones أو الأحداث الرئيسية اللي لازم تحدث
+
+583
+00:54:48,780 --> 00:54:54,480
+في النمو العضلي للإنسان في فترة معينة يعنيفالدوشين
+
+584
+00:54:54,480 --> 00:54:59,840
+مسكولر ديستروفي هو X-linked recessive وحتى
+
+585
+00:54:59,840 --> 00:55:04,800
+الفيميلز سواء لو أحدهم يريد أن يأخذها
+
+586
+00:55:04,800 --> 00:55:10,080
+كـLionization اللي يعني إنه صار Inactive Form في
+
+587
+00:55:10,080 --> 00:55:15,390
+بعض الخلاياوactive في خلايا ثانية أو إنه one copy
+
+588
+00:55:15,390 --> 00:55:20,690
+alone is not enough to produce normal amount of
+
+589
+00:55:20,690 --> 00:55:25,430
+dystrophin needed for normal muscular activity للـ
+
+590
+00:55:25,430 --> 00:55:30,650
+activity تبع العضلات بالنسبة للإنسان فهذا مثال على
+
+591
+00:55:30,650 --> 00:55:38,350
+X-linked recessive في أسئلة الـ
+
+592
+00:55:38,350 --> 00:55:46,310
+X-linked recessiveجدولهم بهذا الشكل إذا
+
+593
+00:55:46,310 --> 00:55:55,610
+أتيت الفتاة الـ Normal في الحالة هذه X capital، XH
+
+594
+00:55:55,610 --> 00:56:04,330
+capital، XH capital تتزوج إنسان مصاب، Male which
+
+595
+00:56:04,330 --> 00:56:08,230
+has been affected فرح يكون عنده Y-chromosome،
+
+596
+00:56:08,230 --> 00:56:17,760
+Male، وعندهالـ «H» ماشي صغير فإذا كانت الفتاة عامة
+
+597
+00:56:17,760 --> 00:56:25,060
+أو عامة تمامًا فهي تتعامل مع شخص عميق أو غير عام
+
+598
+00:56:25,060 --> 00:56:30,360
+فاللي راح يصير أن كل الفتاة راح يصيروا Carriers
+
+599
+00:56:30,360 --> 00:56:35,760
+سبب أنه أخذوا من أبوهم الـ «H» الصغير وكل الفتاة
+
+600
+00:56:35,760 --> 00:56:42,060
+عامة أو غير عامة لأنبيأخذوا من أبوهم الـ Y فهذا
+
+601
+00:56:42,060 --> 00:56:47,720
+زواج Normal Female مع Affected Male أثناء
+
+602
+00:56:47,720 --> 00:56:52,220
+الاختلاف، لو نأخذ أنه Normal Male بهذا الشكل
+
+603
+00:56:52,220 --> 00:57:03,820
+Capital X Capital H ثاني Y اتزوج من Career Female
+
+604
+00:57:03,820 --> 00:57:13,240
+Capital H Small Hالـ Genotype تبعتها اللي راح يصير
+
+605
+00:57:13,240 --> 00:57:23,380
+أنه لهذه العائلة بالنسبة لـ الـ Males ماشي الرُبع
+
+606
+00:57:23,380 --> 00:57:29,540
+يعني الرُبع للـ Offspring اللي بالنسبة لـ Males
+
+607
+00:57:29,540 --> 00:57:36,040
+راح يكونوا Normal وراح يكون الرُبع الثاني affected
+
+608
+00:57:36,040 --> 00:57:42,100
+ماشييعني إذا إمرأة Carrier إتزوجت إنسان طبيعي
+
+609
+00:57:42,100 --> 00:57:49,000
+للولاد، الاحتمالية نص أن يكون affected أو normal
+
+610
+00:57:49,000 --> 00:57:58,980
+وبالنسبة للـ Females، من إلهم، فيه احتمالية ربع
+
+611
+00:57:58,980 --> 00:58:06,280
+normal، non-carrier يعني حطينا normal هنالأنه راح
+
+612
+00:58:06,280 --> 00:58:16,640
+يكون «HH» «HH» «HH» «HH» «HH» «HH» «HH» «HH» «HH»
+
+613
+00:58:16,640 --> 00:58:17,460
+«HH» «HH» «HH» «HH» «HH» «HH» «HH» «HH» «HH» «HH»
+
+614
+00:58:17,460 --> 00:58:17,460
+«HH» «HH» «HH» «HH» «HH» «HH» «HH» «HH» «HH» «HH»
+
+615
+00:58:17,460 --> 00:58:17,480
+«HH» «HH» «HH» «HH» «HH» «HH» «HH» «HH» «HH» «HH»
+
+616
+00:58:17,480 --> 00:58:17,480
+«HH» «HH» «HH» «HH» «HH» «HH» «HH» «HH» «HH» «HH»
+
+617
+00:58:17,480 --> 00:58:33,400
+«HH» «HH» «HH» «HH» «HH» «
+
+618
+00:58:33,530 --> 00:58:40,090
+نُصهم Carrier ونُصهم طبيعيات، فديكون هيك النسب، هي
+
+619
+00:58:40,090 --> 00:58:44,990
+قضيب دي الواحد ينتبه إلها وينتكرها هو أنا بـ
+
+620
+00:58:44,990 --> 00:58:48,970
+degree للـ X-linked recessive disorder في حالة
+
+621
+00:58:48,970 --> 00:58:52,350
+الهيموفيليا A، وتجيبنا صورة عنها، يعني هو أنا
+
+622
+00:58:52,350 --> 00:58:57,050
+الملاحظ في الغالب الـ B degree مثلا زي هذا
+
+623
+00:58:57,050 --> 00:59:04,540
+الإنسان، هذا ولدمشي مربع وبتلاقيه مصاب بتيجي تاخد
+
+624
+00:59:04,540 --> 00:59:12,460
+تاريخ عائلي منه بتلاقي خاله مصاب ماشي والإنسان هذا
+
+625
+00:59:12,460 --> 00:59:19,300
+اللي هاي أمه بتاخد منها تاريخ مرضي كمان بتطلع خاله
+
+626
+00:59:19,300 --> 00:59:31,550
+مصاب يعني أو هنا جد اللي هو بدي أكونجده لأمه،
+
+627
+00:59:31,550 --> 00:59:41,310
+ماشي، هو المصاب فهي الفكرة أول شيء أنه يعني كل
+
+628
+00:59:41,310 --> 00:59:47,650
+المصابين عبارة عن الذكور لو عندي آلية أفحص على الـ
+
+629
+00:59:47,650 --> 00:59:51,430
+«فيميلز» و«كاريارز» و«نورمان» بلاقي أن الـ
+
+630
+00:59:51,430 --> 00:59:55,090
+«فيميلز» هم الـ «كاريارز» اللي حملوا الجين اللي
+
+631
+00:59:55,090 --> 01:00:00,880
+أعطى الحالات اللي نتكلم عنهايعني إذا كان هناك
+
+632
+01:00:00,880 --> 01:00:07,700
+إصابة بأسأل عن الإخوان بدرجة أساسية هذه هي الناحية
+
+633
+01:00:07,700 --> 01:00:15,200
+المهمة يعني فلما تكون بهذا الشكل وبعدين يعني
+
+634
+01:00:15,200 --> 01:00:19,800
+القضية الثانية الـdominant بتلاقي بيظهر في كل
+
+635
+01:00:19,800 --> 01:00:24,160
+الـGenerations هنا في ظهر الـSkipped Generation
+
+636
+01:00:24,160 --> 01:00:32,180
+يعني هذا الجد أعطى لحفيدهمن خلال بناته وبالتالي،
+
+637
+01:00:32,180 --> 01:00:36,500
+يعني فيه skip generation لأنها الـ recessive ليس
+
+638
+01:00:36,500 --> 01:00:41,400
+الـ dominant بس لأنه males أكثر والفemales مافيش
+
+639
+01:00:41,400 --> 01:00:45,320
+ولا واحدة مصابة فبدي يكون X-linked recessive فهي
+
+640
+01:00:45,320 --> 01:00:53,440
+inheritance لـ X-linked recessive في أسئلة؟ الآن،
+
+641
+01:00:53,440 --> 01:00:59,750
+لو فرضنا أنهعلى الـ X-Chromosome بس الـ
+
+642
+01:00:59,750 --> 01:01:05,970
+Inheritance هو X-linked dominant برضه بيصير نظرياً
+
+643
+01:01:05,970 --> 01:01:13,190
+أنا لأ مش بتخيل أي مرض بهذا الشكل، ماشي فبالنسبة
+
+644
+01:01:13,190 --> 01:01:19,290
+للمن يكون إذا فيه X-linked dominant، ماشي إذا فيه
+
+645
+01:01:19,290 --> 01:01:25,660
+Female عندها إصابةاللي في الحالة هذه الـ capital D
+
+646
+01:01:25,660 --> 01:01:34,120
+small d على الـ X فاللي راح يصير الـ Gametes
+
+647
+01:01:34,120 --> 01:01:36,980
+تبعاتهم في واحدة الـ capital D فيها مرض و الـ
+
+648
+01:01:36,980 --> 01:01:45,060
+small d ليس فيها مرض الشيء المالي XY الـ Y مافيش
+
+649
+01:01:45,060 --> 01:01:52,140
+عليه أي شيء الـ X small d ففي الحالة هذهالـ
+
+650
+01:01:52,140 --> 01:01:58,780
+Females ربعهم يعني لما تكون Female راح يكون الربع
+
+651
+01:01:58,780 --> 01:02:03,380
+أو نص الـ Females affected ونص الـ Females normal
+
+652
+01:02:03,380 --> 01:02:10,260
+ونص الـ Males affected ونص الـ Males unaffected أو
+
+653
+01:02:10,260 --> 01:02:16,190
+normalهي لأنها بتكون أربع وبدل واحد يحطها بالنسبة
+
+654
+01:02:16,190 --> 01:02:22,550
+Male و Female يقسمها بس لكل جنس Males أو Females
+
+655
+01:02:22,550 --> 01:02:31,410
+نص بنص لأن هذه نص بنص لما يكون Male affected
+
+656
+01:02:31,410 --> 01:02:39,270
+capital D ماشي والـ Female normal بهذا الشكل small
+
+657
+01:02:39,270 --> 01:02:45,170
+d small dإذا على كابتل D All females are affected
+
+658
+01:02:45,170 --> 01:02:53,290
+لأن XD Xd وبالنسبة للمالز All are unaffected لأنه
+
+659
+01:02:53,290 --> 01:02:58,110
+راح يعطيهم كمال بياخدوا من أبوهم الـY كرمزوم ما
+
+660
+01:02:58,110 --> 01:03:02,390
+بياخدوا الـX كرمزوم فالـX كرمزوم راح ياخدوه من
+
+661
+01:03:02,390 --> 01:03:07,800
+الـM والـM مش مصعبة ومافيش فيها مشكلةفالفكرة إنه
+
+662
+01:03:07,800 --> 01:03:14,760
+إذا شُفت بهذا الطريقة من الـ Inheritance إنه يعني
+
+663
+01:03:14,760 --> 01:03:17,860
+لو
+
+664
+01:03:17,860 --> 01:03:24,260
+شُفت أنا هنا كنت أنا من خلال يعني إن الـ Female هي
+
+665
+01:03:24,260 --> 01:03:28,130
+اللي affectedبشوفها زي الـ Autosomal Dominant
+
+666
+01:03:28,130 --> 01:03:34,130
+Inheritance إنه كلا الناس وكلا الفتاة يتأثرون بشكل
+
+667
+01:03:34,130 --> 01:03:38,510
+متساوي أو يمكن أن يكونوا متأثرين بشكل متساوي ومن
+
+668
+01:03:38,510 --> 01:03:44,370
+الأم للأولاد مافيش skip generation ففي الحالة هذه
+
+669
+01:03:44,950 --> 01:03:52,650
+هي Dominant Inheritance بس لما يكون فيه فرق بين
+
+670
+01:03:52,650 --> 01:03:59,430
+الأب والأم إذا مصابين بهذا الشكل ماشي بتعطيني
+
+671
+01:03:59,430 --> 01:04:03,670
+Indicator إنه هاي X-Link Dominant Inheritance يعني
+
+672
+01:04:03,670 --> 01:04:12,310
+هنا حاطين مثال هذا زلمة الـGeneration الأول مصاب
+
+673
+01:04:12,310 --> 01:04:21,920
+أعطى بناتهماشي فهن مصابات البنات لما نتزوجن برضه
+
+674
+01:04:21,920 --> 01:04:29,580
+فيه بنات وذكور مصابين وفي كل generation، ماشي فهي
+
+675
+01:04:29,580 --> 01:04:35,400
+على الأقل بتعطيني Indicator إنه هذه عبارة عن
+
+676
+01:04:35,400 --> 01:04:38,880
+dominant
+
+677
+01:04:39,440 --> 01:04:45,780
+Inheritance هذه بما أن في كل الأجيال في ناس مصابين
+
+678
+01:04:45,780 --> 01:04:58,240
+إنه Dominant Pattern بس الحالة هذه ماشية يعني إذا
+
+679
+01:04:58,240 --> 01:05:06,300
+بلاحظ شغل ثانية أو بلاحظ ناحية معينة إنه لما يكون
+
+680
+01:05:06,300 --> 01:05:14,710
+المصاب ذكر ماشيكل ولاده طبيعيين وكل بناته مصابة
+
+681
+01:05:14,710 --> 01:05:23,870
+يعني هذا كمان ذكر ثاني مصاب كل ولاده طبيعيين بيض
+
+682
+01:05:23,870 --> 01:05:30,890
+والبنات مصابة الـ Female مثلاً لما ناخد مثل هذه
+
+683
+01:05:30,890 --> 01:05:39,990
+المصابة أعطت ولاد وبنات مصابين فهذهالـ Inheritance
+
+684
+01:05:39,990 --> 01:05:45,330
+تبعة الـ X-Linked Dominant Inheritance واللي
+
+685
+01:05:45,330 --> 01:05:51,710
+بيحكوا عنه هنا قضية ثانية إن أحيانًا لما يكون
+
+686
+01:05:51,710 --> 01:05:55,670
+الإصابة
+
+687
+01:05:55,670 --> 01:06:01,350
+بالنسبة للمال لأن في نسخة واحدة شديدة كثير أحيانًا
+
+688
+01:06:01,350 --> 01:06:07,510
+يعني بيسموه Lethal Geneيعني سواء إن هذا في الـ
+
+689
+01:06:07,510 --> 01:06:12,230
+Autosomal أو في الـ X-link إذا كان إنه لما يكون
+
+690
+01:06:12,230 --> 01:06:18,310
+عندي Two copies في حالة الـ Autosomal recessive أو
+
+691
+01:06:18,310 --> 01:06:22,090
+في حالة الـ X-linked recessive في الميل إذا One
+
+692
+01:06:22,090 --> 01:06:27,650
+copy يعني الواحد ماعندهوش أي جين طبيعي تماماً
+
+693
+01:06:28,100 --> 01:06:32,440
+أحيانًا حتى في الـ Empionic Period أو في مرحلة
+
+694
+01:06:32,440 --> 01:06:37,840
+معينة ممكن ينتج عنه أنه يكون Lethal فلمّا يكون
+
+695
+01:06:37,840 --> 01:06:42,520
+Lethal الـGene بيغير الـPercentages الـPossible
+
+696
+01:06:42,520 --> 01:06:51,150
+تطلع اللي أحنا بنشوفها، ماشي؟فهنا هذا مثال بيكون
+
+697
+01:06:51,150 --> 01:06:55,630
+«Ex-linked dominant
+
+698
+01:06:55,630 --> 01:07:01,450
+inheritance» بس كمان فوق هذا أنه «Lethal gene» أنه
+
+699
+01:07:01,450 --> 01:07:05,410
+مافيش «Males affected» هذه برضه أحيانًا بتحدث
+
+700
+01:07:05,410 --> 01:07:13,310
+موجودة وبتكون يعني ظاهرة موجودة في أسئلة؟ في سؤال
+
+701
+01:07:13,310 --> 01:07:20,490
+دكتور من كريمبيقول لما يكون الجنين ذكر ميت، ليش ما
+
+702
+01:07:20,490 --> 01:07:25,210
+بينذكر في شجرة العائلة؟ مش في رمز للجنين الذكر أو
+
+703
+01:07:25,210 --> 01:07:32,610
+الجنين الميت؟ صحيح، صحيح، احنا هنا يعني أحيانا
+
+704
+01:07:32,610 --> 01:07:39,610
+نحكي عن ظاهرة اللي هي في ال .. يعني إذا اتأخر قبل
+
+705
+01:07:39,610 --> 01:07:46,380
+ما صارت الوفاةوبيّن حملة بشكل واضح بس إذا بتتذكر
+
+706
+01:07:46,380 --> 01:07:53,160
+حكينا إنه أحياناً في أوائل الحمل شهر الأول يمكن
+
+707
+01:07:53,160 --> 01:07:57,880
+حتى ما يبينش على المرأة إن أنا حامل يعني بتكون يا
+
+708
+01:07:57,880 --> 01:08:02,480
+دوبك اتأخرت الدورة يومين، تلاتي وبعدين نزلت دورة
+
+709
+01:08:02,480 --> 01:08:09,740
+شديدة وبس يعني فأحياناً حسب همية الجين ودوره ومش
+
+710
+01:08:09,740 --> 01:08:14,970
+بيتدخل أحياناً ما بيبينشفاهم عليك كيف؟ أما إذا
+
+711
+01:08:14,970 --> 01:08:22,750
+الأصل إنه إحنا بنعمل شجرة عائلة لازم نيجي ونحاول
+
+712
+01:08:22,750 --> 01:08:27,610
+نحط كل المعلومات بصدق و بحقيقة شو اللي شفناها و
+
+713
+01:08:27,610 --> 01:08:33,670
+بنسأل الأهل و شو صار و كده فكرة اللي بيسموها الـ
+
+714
+01:08:33,670 --> 01:08:42,010
+Lethal Gene اللي هي إنه الإصابة سواء إذا Recessive
+
+715
+01:08:42,650 --> 01:08:47,130
+معناته لازم تُو copies حتى تصبح لصابي أو إذا was
+
+716
+01:08:47,130 --> 01:08:51,250
+recessive للـ X-linked بدي يكون في الـ nails لأنه
+
+717
+01:08:51,250 --> 01:08:56,250
+100% الجينات مصابة يعني في الحالتين هذولة بيسموه
+
+718
+01:08:56,250 --> 01:09:01,930
+lethal gene ففي حالة هذه سواء ذكر ولا أنثى ما
+
+719
+01:09:01,930 --> 01:09:07,970
+بعيش، ما بتقدم، ما يعني إذا بيّن معاي
+
+720
+01:09:10,660 --> 01:09:16,460
+وأنا بالنسبة لـ .. يعني إذا أخدنا مثلا الصورة هذه،
+
+721
+01:09:16,460 --> 01:09:20,420
+ماشي الفكرة،
+
+722
+01:09:20,420 --> 01:09:28,520
+هذه الأنثة مثلا جابت بنات طبيعيات، ماشي وهنا، هذه
+
+723
+01:09:28,520 --> 01:09:32,440
+مصابة زي أمها، بس فيه بنت طبيعية لما تكون البنت
+
+724
+01:09:32,440 --> 01:09:35,240
+طبيعية، معناته أنه
+
+725
+01:09:37,610 --> 01:09:47,030
+هيستحيل هذه الظاهرة تكون Excellent Recessive
+
+726
+01:09:47,030 --> 01:09:54,750
+لأنه لو Recessive، ماشي، لو Recessive كانت البنات
+
+727
+01:09:54,750 --> 01:10:01,010
+كلهم راح يكونوا لأن الـ Two Cups involved فبكون
+
+728
+01:10:01,010 --> 01:10:05,550
+أنه تظهر واحدة طبيعية من البنات معناته أكيد الأم
+
+729
+01:10:07,220 --> 01:10:14,580
+بدنا نسميها الـ Trosius يعني الـ Two Cups مختلفة
+
+730
+01:10:14,580 --> 01:10:18,620
+حتى يعطينا بهذا الشكل للـ Females إذا على الـ X
+
+731
+01:10:18,620 --> 01:10:22,520
+-Chromosome وحتى على الـ Autosomal Chromosome لازم
+
+732
+01:10:22,520 --> 01:10:27,080
+تكون الـ Cups مختلفة لما أنا أشوف آلة بهذه الطريقة
+
+733
+01:10:27,080 --> 01:10:32,260
+أنه لأكثر من Generation وفيه مصابين وفيه غير
+
+734
+01:10:32,260 --> 01:10:39,600
+مصابين يعني بهذا الشكلمعناته في إنه إذا كان
+
+735
+01:10:39,600 --> 01:10:48,020
+homozygous لهذه الـ «شخصية» سواءً بالـ Males لما
+
+736
+01:10:48,020 --> 01:10:51,900
+تكون على الـ X و One copy أو إذا فيه Male، Two
+
+737
+01:10:51,900 --> 01:10:59,720
+copies، بيكونوا مصابين، بنتج عنه إنه بيكون الـ
+
+738
+01:10:59,720 --> 01:11:05,640
+بيكون فيه lethal gene، كما نسميهإنه راح يكون يتسبب
+
+739
+01:11:05,640 --> 01:11:12,200
+بالوفاة الجنين قبل ما حتى يولد يعني بدّي الواحد
+
+740
+01:11:12,200 --> 01:11:18,140
+ينتبهي لها فهي من العوامل اللي بتخربط بتخربط
+
+741
+01:11:18,140 --> 01:11:23,740
+الظواهر يعني بتخلّي النسب ما تكون زي اللي حكيناها
+
+742
+01:11:23,740 --> 01:11:28,340
+وتوقعناها حسب الـ Genotype و الـ Phenotype تبعنا،
+
+743
+01:11:28,340 --> 01:11:28,920
+واضح؟
+
+744
+01:11:33,020 --> 01:11:39,620
+هنا نأخذ عائلة عندهم Female Epilepsy وCognitive
+
+745
+01:11:39,620 --> 01:11:45,940
+Impairment Syndrome يعني في عائلة النساء عندهم
+
+746
+01:11:45,940 --> 01:11:51,640
+بيصير معاهم seizures و بيصير معاهم يعني بعض درجة
+
+747
+01:11:51,640 --> 01:11:57,220
+بسيطة من التخلف العقلي، ماشي فهي X-linked dominant
+
+748
+01:11:57,220 --> 01:11:58,220
+inheritance
+
+749
+01:12:00,720 --> 01:12:06,920
+الـ «الملابس غير مهاجمة» «الملابس غير مهاجمة»
+
+750
+01:12:06,920 --> 01:12:07,760
+«الملابس غير مهاجمة» «الملابس غير مهاجمة» «الملابس
+
+751
+01:12:07,760 --> 01:12:07,760
+غير مهاجمة» «الملابس غير مهاجمة» «الملابس غير
+
+752
+01:12:07,760 --> 01:12:07,960
+مهاجمة» «الملابس غير مهاجمة» «الملابس غير مهاجمة»
+
+753
+01:12:07,960 --> 01:12:07,960
+«الملابس غير مهاجمة» «الملابس غير مهاجمة» «الملابس
+
+754
+01:12:07,960 --> 01:12:07,960
+غير مهاجمة» «الملابس غير مهاجمة» «الملابس غير
+
+755
+01:12:07,960 --> 01:12:15,520
+مهاجمة» «الملابس غير مهاجمة» «الملابس
+
+756
+01:12:15,520 --> 01:12:25,900
+غير مهاجمة» «الملابس غير مهاجمة» «الملابس غير
+
+757
+01:12:25,900 --> 01:12:31,970
+مهاجمة» «الملافهذه الـ Pedigree العائلة أول شيء
+
+758
+01:12:31,970 --> 01:12:38,930
+الجد بالـ Generation الأول كانت مصابة ماشي، زوجها
+
+759
+01:12:38,930 --> 01:12:47,570
+اتوفى، طبيعي كان الملاحظ، ماشي، هذه X-linked
+
+760
+01:12:47,570 --> 01:12:52,330
+dominant inheritance الملاحظ أن الـFemales هم
+
+761
+01:12:52,330 --> 01:12:59,370
+الوحيديات الـaffected وكل Generationوكل generation
+
+762
+01:12:59,370 --> 01:13:04,470
+فيه مصابين أو مصابات في الحالة هذه فهذا disease
+
+763
+01:13:04,470 --> 01:13:12,050
+الـ X-linked dominant inheritance ماشي، الـ males
+
+764
+01:13:12,050 --> 01:13:20,650
+hemizygous for a premature termination المالز
+
+765
+01:13:20,650 --> 01:13:32,080
+بياخدوا من الأم one copyوالأم يعني لازم تكون تظامن
+
+766
+01:13:32,080 --> 01:13:38,440
+X-linked dominant فالأم في الحالة هذه مستحيل تكون
+
+767
+01:13:38,440 --> 01:13:44,080
+homozygous للـ Two copies تكون مصابات لأنه فيه من
+
+768
+01:13:44,080 --> 01:13:50,800
+بناتها فيه مصابات وفيه طبيعيات ماشي ففيه مصابات
+
+769
+01:13:50,800 --> 01:13:51,800
+وفيه طبيعيات
+
+770
+01:13:54,290 --> 01:14:00,370
+فهذه ممكنة وهذه تحدث ويجب أن يكون الواحد ينتبه لها
+
+771
+01:14:00,370 --> 01:14:03,910
+ويدرسها
+
+772
+01:14:03,910 --> 01:14:10,250
+الموضوع هذه الفكرة مرة ثالثة أو مرة رابعة أو خامسة
+
+773
+01:14:10,250 --> 01:14:16,690
+لما تشوف كل جيل فيه إصابات هذا الواضح ماشي، مافيش
+
+774
+01:14:16,690 --> 01:14:21,140
+skip generation، هذه ناحية، الناحية الثانيةواضح
+
+775
+01:14:21,140 --> 01:14:23,900
+هنا إن الـ Females هم اللي affected والـ Males
+
+776
+01:14:23,900 --> 01:14:29,880
+normal يعني هنا Normal Male وهنا Career Male
+
+777
+01:14:29,880 --> 01:14:40,300
+تعتبروه أو Hemizygous للمل مش مؤثر عليه فيعني
+
+778
+01:14:40,300 --> 01:14:46,680
+هذه X-linked dominant في
+
+779
+01:14:46,680 --> 01:14:57,020
+الحالة هذهبـDegree Showing Dyschondrosis أو
+
+780
+01:14:57,020 --> 01:15:03,560
+Dyschondrostiosis هذا مرض، يعني بتوقع بيكون فيه
+
+781
+01:15:03,560 --> 01:15:09,420
+خلل بالعظام ونمو العظام والـ Cartilage أو الغضاريف
+
+782
+01:15:09,420 --> 01:15:14,940
+تبع الـ Disease
+
+783
+01:15:14,940 --> 01:15:22,570
+هذادكتور، في سؤال من كريم بيقول «شو الـ Genotype
+
+784
+01:15:22,570 --> 01:15:29,950
+للمال الكارير؟» في الحالة هذه يعني الاصل والمال
+
+785
+01:15:29,950 --> 01:15:36,410
+السليم طبعاً كمان آه، يعني إذا بتتذكر لما حطينا
+
+786
+01:15:36,410 --> 01:15:43,190
+صورة الـ Duchene muscular dystrophy ماشي، إذا
+
+787
+01:15:43,190 --> 01:15:47,360
+بتتذكر صورة الـ Ducheneيعني بس عشان أذكر قضية
+
+788
+01:15:47,360 --> 01:15:55,200
+معينة الآن هذا الإنسان بشوفه طبيعي، phenotype وهذه
+
+789
+01:15:55,200 --> 01:16:00,760
+الـ Female اللي هي الـ carrier الأصل أني لما قاعدي
+
+790
+01:16:00,760 --> 01:16:05,520
+أنا أفحصها كـ muscle power أو أشوفها وكذا، بلاقيها
+
+791
+01:16:05,520 --> 01:16:12,180
+طبيعيةبس أنا إذا عندي أدوات أفحص بشكل أدق على الـ
+
+792
+01:16:12,180 --> 01:16:16,360
+Gene Expression على البروتين، على الـ RNA، على كذا
+
+793
+01:16:16,360 --> 01:16:23,540
+ممكن أشوف درجات من الـ Phenotype بتكون مختلفة،
+
+794
+01:16:23,540 --> 01:16:31,430
+واضح؟فيعني هنا حاطينا كصورة هي يعني بدل واحد يعني
+
+795
+01:16:31,430 --> 01:16:37,950
+يدخل في الـReference تبع هذه الـStudy تبعت هذه
+
+796
+01:16:37,950 --> 01:16:42,210
+العيلة كيف فحصوها؟ كيف؟ شو اللي فحصوا عليه؟ وكيف
+
+797
+01:16:42,210 --> 01:16:46,650
+أثبتوا إنه هذا Career ومش Career؟ والكلام هذا،
+
+798
+01:16:46,650 --> 01:16:55,970
+فاهم عليا كيف؟ بس يعني بشكل عامالأبيض الأصل عام
+
+799
+01:16:55,970 --> 01:17:02,970
+والأزرق كامل مصاب، هيك بفهم اللي هي يعني بشكل عام،
+
+800
+01:17:02,970 --> 01:17:07,430
+مبدأ فالآن يعني أنا بفهم إنه في الـSecond
+
+801
+01:17:07,430 --> 01:17:14,010
+Generation الـTwo Males هذولة طبيعيين مظهريًا،
+
+802
+01:17:14,010 --> 01:17:20,210
+ماشي؟ بس كل واحد منهم أعطى بنته من البنات اللي
+
+803
+01:17:20,210 --> 01:17:28,470
+عندهمن أمه فبكون هو حامل إشي معين يمكن مظهريًا أنا
+
+804
+01:17:28,470 --> 01:17:35,150
+لازم أعرف أنه يعني أنا استنتجت أنه career بس لأنه
+
+805
+01:17:35,150 --> 01:17:43,260
+نقل المرض بس شو بالضبط بيّن عليه بحيث أنهبأي طريقة
+
+806
+01:17:43,260 --> 01:17:48,200
+فحصناها حتى نتثبت إنه فعلاً هو Career وين الـ X
+
+807
+01:17:48,200 --> 01:17:52,520
+-Chromosome وليش، مع أنه عنده نسخة واحدة الأصل هذا
+
+808
+01:17:52,520 --> 01:18:01,200
+dominant يعني dominant بمعنى لازم يظهر، هيك الأصل،
+
+809
+01:18:01,200 --> 01:18:05,020
+ماشي، لما نكون في عندي Two copies، One copy بتكفي
+
+810
+01:18:05,020 --> 01:18:10,500
+حتى يظهر المرض، فهذه هنا يعني بدأتكون داخلة فيها
+
+811
+01:18:10,500 --> 01:18:17,810
+موضوعاللي حكينا عنه قضية الأحيانًا الـ X-linked
+
+812
+01:18:17,810 --> 01:18:26,690
+يعني التأثير اللي موجود زي حكينا عن حكاية الصلع في
+
+813
+01:18:26,690 --> 01:18:32,570
+الـ Males بيكون certain gene dominant والـ Females
+
+814
+01:18:32,570 --> 01:18:35,990
+بيصير recessive يعني بدأت تكون صارت ظاهرة بهذا
+
+815
+01:18:35,990 --> 01:18:44,100
+الشكل حتى الواحد يفسرها، واضح؟بيقول يعني هو يعني
+
+816
+01:18:44,100 --> 01:18:48,260
+نفهم إنه الـ «مايل» الحامل هو في الأصل يعني مصعب
+
+817
+01:18:48,260 --> 01:18:54,620
+ولكن ما ظهرت عليه الأعراض؟ أنا حكيت يعني أحيانًا
+
+818
+01:18:54,620 --> 01:19:01,800
+لما نقول «dominant» و لا «recessive» ماشي الكلمة
+
+819
+01:19:01,800 --> 01:19:09,140
+زي هيك فيه كمان درجات في الاختلاف بين الـ«مايل»
+
+820
+01:19:09,140 --> 01:19:18,240
+والـ«فيميل»يعني ممكن ظاهرة معينة تكون dominant في
+
+821
+01:19:18,240 --> 01:19:23,480
+الـ Female يعني قصدي One copy is enough وكذا،
+
+822
+01:19:23,480 --> 01:19:30,480
+وبالـ Males تصير recessive القصد فيها إنه بتلاقي
+
+823
+01:19:30,480 --> 01:19:35,900
+جينات ثانية، أشياء ثانية ما خلّت المظهر الموجود،
+
+824
+01:19:35,900 --> 01:19:42,420
+واضح؟فهي طريقة يحاولون من خلالها يفسروا
+
+825
+01:19:42,420 --> 01:19:48,580
+الـpedigrees اللي بيشوفوها طبعاً يعني مين اتزوج
+
+826
+01:19:48,580 --> 01:19:55,180
+مين وفعلاً مافيش أي ضواهر ثاني تتدخل في التفسير
+
+827
+01:19:55,180 --> 01:19:58,020
+يعني
+
+828
+01:19:59,130 --> 01:20:05,510
+ممكن أحيانًا تطلب تاريخ عائلة من عائلة ممتدة ويكون
+
+829
+01:20:05,510 --> 01:20:12,070
+مثلًا واحد مايعرفش تمامًا مين عمه ولا خالته،
+
+830
+01:20:12,070 --> 01:20:17,350
+اتجوزها مين وكذا، يعني ممكن يكون في بعض القصور
+
+831
+01:20:17,350 --> 01:20:25,190
+أحيانًا يعني فالفكرة يعني مرة أخيرة بقول إذا بتشوف
+
+832
+01:20:25,190 --> 01:20:30,290
+الذكور والإنس زي بعضبدّك تقول autosomal إذا فيه
+
+833
+01:20:30,290 --> 01:20:34,630
+فرق كبير الأصل إذا males بتقول X-linked recessive
+
+834
+01:20:34,630 --> 01:20:39,790
+إذا فيه males بدّك تقول X-linked dominant والشغل
+
+835
+01:20:39,790 --> 01:20:45,450
+الثاني إذا بتشوف كل ال generations مصعبين،
+
+836
+01:20:45,450 --> 01:20:49,330
+dominant إذا فيه skip generation، بدّي يكون فيه
+
+837
+01:20:49,330 --> 01:20:52,850
+recessive فاهم عليك إيه؟ فبدا كأي نواحي تنتبه
+
+838
+01:20:52,850 --> 01:21:03,130
+إليهاوفيه كمان بواهر زي الـ Lethal Gene وقضية الـ
+
+839
+01:21:03,130 --> 01:21:09,950
+Penetrance أو درجة قدرة الجين على الظهور أحيانًا
+
+840
+01:21:09,950 --> 01:21:15,550
+فيه درجة بسيطة من الخلل بحيث أنه أحيانًا بتعد على
+
+841
+01:21:15,550 --> 01:21:21,140
+أنه طبيعيفأحيانًا يعني هذه ظاهرة بتكون موجودة يعني
+
+842
+01:21:21,140 --> 01:21:27,260
+صحيح هو dominant بس لسبب أو لآخر من جينات أخرى
+
+843
+01:21:27,260 --> 01:21:37,380
+المظهر ما بيّن، ماشي؟ فهنا حاطين
+
+844
+01:21:37,380 --> 01:21:42,540
+إنه ممكن يكون الـY-Chromosome فيه دخل ويعتبر زي
+
+845
+01:21:42,540 --> 01:21:47,910
+الـPseudo Autosomal الـGene on the X and Yفصحيح
+
+846
+01:21:47,910 --> 01:21:53,010
+يعني هو مكانه على الـ X-Chromosome بس كمان الـ Y
+
+847
+01:21:53,010 --> 01:21:58,370
+فيه إشي موجود أحيانًا يعني الـ X-Chromosome وY
+
+848
+01:21:58,370 --> 01:22:04,550
+-Chromosome في بعض الجينات أحيانًا تتدخل يعني زي
+
+849
+01:22:04,550 --> 01:22:11,590
+مثلًا وجود الشعر على صيوان الأذن «هيريبينيا» هذه
+
+850
+01:22:11,590 --> 01:22:18,870
+ظاهرة Y-Chromosome Controlledيعني المسؤول عنها الـ
+
+851
+01:22:18,870 --> 01:22:25,770
+Y-Chromosome مثلاً فأحياناً بتلاقي عائلات أو حالات
+
+852
+01:22:25,770 --> 01:22:30,750
+بتلاقي فيهم أشياء وإذا الشغل صدفت إنه موجود على
+
+853
+01:22:30,750 --> 01:22:35,690
+الـ X والـ Y فصارت قريبة من إذا كانت موجودة على
+
+854
+01:22:35,690 --> 01:22:39,470
+الثانين الـ X والـ Y فراح يصير إن هاي الـ X والـ Y
+
+855
+01:22:39,470 --> 01:22:44,510
+تقريبًا راح يكون زي الـالـ autosomal gene يعني مش
+
+856
+01:22:44,510 --> 01:22:51,430
+X-linked related نقطة
+
+857
+01:22:51,430 --> 01:22:56,550
+أو ظاهرة أخيرة أو جانب آخر فيها سؤالة، إذا حد عنده
+
+858
+01:22:56,550 --> 01:23:02,770
+سؤال، واقفوني الفكرة
+
+859
+01:23:02,770 --> 01:23:05,850
+دايماً
+
+860
+01:23:05,850 --> 01:23:13,220
+لازم الواحد يحط باله إنه أحياناًفعلًا، أه إنسان
+
+861
+01:23:13,220 --> 01:23:20,260
+يعني مثلًا ما عندهم مش المرض ومافيش سالمين تمامًا
+
+862
+01:23:20,260 --> 01:23:25,860
+وبيجيهم طفل مصاب بـ Orthosomal Dominant طب ما هو
+
+863
+01:23:25,860 --> 01:23:29,920
+هذا إذا هذا Orthosomal Dominant وعرفنا إن هذا هو
+
+864
+01:23:29,920 --> 01:23:34,540
+المشكلة بهذا الشكل، بيقول مستحيل، لازم واحد من
+
+865
+01:23:34,540 --> 01:23:40,880
+أبائهيا لأ أب أو الأم لازم يكون واحد منهم مصاب
+
+866
+01:23:40,880 --> 01:23:46,760
+وتكون نتيجة أنه صارت الطفرة الوراثية في نفس الطفل
+
+867
+01:23:46,760 --> 01:23:53,280
+فهذه ناحية، يعني هذه جانب يجب أن يتذكر الواحد لأن
+
+868
+01:23:53,280 --> 01:23:58,040
+أحيانًا أنا مارح ألاقي في تاريخ العائلة وشجرة
+
+869
+01:23:58,040 --> 01:24:04,840
+العائلة مصابين بهذه الحالة والسبب أنهبتلاقيها
+
+870
+01:24:04,840 --> 01:24:11,980
+عبارة عن يعني لأنه مش موجود ولو استطعت أفحص على
+
+871
+01:24:11,980 --> 01:24:17,600
+الجينات المسببة لهذا المرض بلاقيها مش موجودة فبقول
+
+872
+01:24:17,600 --> 01:24:23,300
+إن المشكلة بدأت في الطفرة في نفس الطفل هذا أو
+
+873
+01:24:23,300 --> 01:24:29,560
+الإنسان هذا الفكرة اللي بدل واحد كمان يتذكرها قضية
+
+874
+01:24:29,560 --> 01:24:35,200
+اللي هي إن الإنسانمش كل خلايا متشابهة تماماً مائة
+
+875
+01:24:35,200 --> 01:24:45,580
+بالمائة يعني إحنا بنحب نعتقد إنه الـ «DNA» تبع كل
+
+876
+01:24:45,580 --> 01:24:50,720
+خلايا الإنسان متشابه هيك الأصل هيك المتوقع هيك
+
+877
+01:24:50,720 --> 01:24:53,000
+المفروض من ناحية
+
+878
+01:24:56,480 --> 01:25:01,420
+من ناحية إنه في كل من الـFertilized egg الأولى
+
+879
+01:25:01,420 --> 01:25:08,740
+اللي بتكون منها الإنسان بينتج كله دايماً انقسام
+
+880
+01:25:08,740 --> 01:25:14,840
+منصف أو انقسام كامل مائة بالمائة بحيث يكون كلها
+
+881
+01:25:14,840 --> 01:25:18,860
+copies من نفس الأشياء الفكرة اللي بدل واحد كمان
+
+882
+01:25:18,860 --> 01:25:26,120
+يذكرها إن أحياناً الـMutation تنشأ فيوواحدة من
+
+883
+01:25:26,120 --> 01:25:31,380
+البنات أو الخلايا على مستوى مثلًا هنا هذه الخلية
+
+884
+01:25:31,380 --> 01:25:36,120
+انقسمت لخليتين بشكل طبيعي انقسمت بعدين مرة ثانية
+
+885
+01:25:36,120 --> 01:25:41,980
+فصارت أربعة بس صارت ميوتيشن بين الـSecond Cell
+
+886
+01:25:41,980 --> 01:25:48,320
+والثالث Generation فاللي راح يصير أنه بهذه الطريقة
+
+887
+01:25:48,320 --> 01:25:53,210
+الثلاث تربع الخلايا راح تكون بشكلوربعها راح يكون
+
+888
+01:25:53,210 --> 01:26:00,610
+بشكل آخر بيصير فيه mutation فهذه يعني الـ mutation
+
+889
+01:26:00,610 --> 01:26:06,290
+أو الطفرة هذه الفكرة فيها أنها حدثت بعد التخصيب
+
+890
+01:26:06,290 --> 01:26:09,330
+«after conception» و «during mitotic cell
+
+891
+01:26:09,330 --> 01:26:19,750
+divisions» فهذه بينتج عنها أنه بالنسبة
+
+892
+01:26:19,750 --> 01:26:26,800
+للـللظاهرة هذه إنه بعض الخلايا راح تكون بشكل
+
+893
+01:26:26,800 --> 01:26:30,940
+وخلايا بتكون يعني اللي هي بيسموه الـ Mosaicism
+
+894
+01:26:30,940 --> 01:26:35,440
+اللي هي إنه بيكون أكثر من شكل فالنقطة اللي ما فيها
+
+895
+01:26:35,440 --> 01:26:44,640
+هنا إنه إذا هذه الظاهرة حدثت في الخلايا الجنسية
+
+896
+01:26:44,640 --> 01:26:50,860
+يعني في الخصية أو في الـ Ovary راح ممكن الصفة هذه
+
+897
+01:26:50,860 --> 01:26:59,630
+تنتقلوإذا ما حدثتش هناك بس في خلايا الجسم وما كانت
+
+898
+01:26:59,630 --> 01:27:05,070
+في الخلايا الجنسية فلن تنتقل للأبناء والبنات بعدين
+
+899
+01:27:05,070 --> 01:27:08,230
+حسب
+
+900
+01:27:08,230 --> 01:27:13,930
+في أي مرحلة في التم، في أي tissue يعني في أي نسيج
+
+901
+01:27:13,930 --> 01:27:18,750
+اللي
+
+902
+01:27:18,750 --> 01:27:22,610
+دخل فيه إنه ممكن هذه الصفة الورافية تنتقل أو ما
+
+903
+01:27:22,610 --> 01:27:28,080
+تنتقلتفهذه ناحية مهمة وهذه ظاهرة بتحدث لما ندرس أي
+
+904
+01:27:28,080 --> 01:27:33,760
+إنسان بدقة عالية نوعية الجينات اللي موجود عنده في
+
+905
+01:27:33,760 --> 01:27:41,800
+الخلايا ممكن يلاقي فيه اختلافات ومزايك
+
+906
+01:27:41,800 --> 01:27:48,440
+من الجينات وبتكون فيه اختلافات موجودة في نسب معين
+
+907
+01:27:48,440 --> 01:27:55,170
+من الخلايا وبتكون إن الـMutation صارتمش في الـ
+
+908
+01:27:55,170 --> 01:28:02,810
+Pluripotent أو الأول الخلية، لأ في مرحلة لاحقة
+
+909
+01:28:02,810 --> 01:28:12,790
+وبتكون تعطي مشكلة في نص الخلايا فهنا
+
+910
+01:28:12,790 --> 01:28:16,150
+بيحطون
+
+911
+01:28:16,150 --> 01:28:22,530
+أمثلة مثلًا الـ Marfan Syndromeهو Autismal
+
+912
+01:28:22,530 --> 01:28:31,770
+Dominant Disorder طيب، باجي أنا بشوف هذه العائلة
+
+913
+01:28:31,770 --> 01:28:38,610
+الرجل هذا ماشي عند زوجتين أو على فترتين في حياته
+
+914
+01:28:38,610 --> 01:28:50,970
+الزوج إمثال فمنهم جاب ولد وابنت مصاباتيعني هذولة
+
+915
+01:28:50,970 --> 01:28:57,650
+مش أشقاء، يعني أخوة من الأب فقط والأمهات مختلفات،
+
+916
+01:28:57,650 --> 01:29:05,790
+واثنين مصابين، ماشي؟ شو بنقدر نقول عن هذه العائلة؟
+
+917
+01:29:05,790 --> 01:29:11,570
+إحنا بنعرف بالنسبة للـ Marfan Syndrome إنه
+
+918
+01:29:11,570 --> 01:29:16,710
+Autismal Dominant يعني واضح المشترك بين أمه والأب،
+
+919
+01:29:16,710 --> 01:29:22,330
+والأصل إنه كان إنه مصابفبما أنه غير مصاب لما قاعد
+
+920
+01:29:22,330 --> 01:29:27,670
+أدرس الجينات تبعته راح ألاقي في الغالب إنه صار
+
+921
+01:29:27,670 --> 01:29:31,590
+معاه ظاهرة إنه عنده الـ mutation بس الـ mutation
+
+922
+01:29:31,590 --> 01:29:38,040
+مش في الأول خلية من خلايا لما اتكونتيعني مش الطفرة
+
+923
+01:29:38,040 --> 01:29:42,060
+موجودة في كل الخلايا إنما موجود في جزء من الخلايا
+
+924
+01:29:42,060 --> 01:29:46,540
+وموجود في جزء من الخلايا اللي في الخصية عنده اللي
+
+925
+01:29:46,540 --> 01:29:56,360
+هي خلّت ولاده وبناته عندهم مشكلة هنا مثال آخر ماشي
+
+926
+01:29:56,360 --> 01:30:02,540
+برضهعلى إنه عائلة عندها X-linked اللي هو Recessive
+
+927
+01:30:02,540 --> 01:30:06,560
+Picard Muscular Dystrophy البكر قريب من الدشين
+
+928
+01:30:06,560 --> 01:30:11,760
+Muscular Dystrophy برضه سبب لضعف العضلات بس الدشين
+
+929
+01:30:11,760 --> 01:30:17,100
+بيكون Very Severe بيبدأ من الطفولة المبكرة وبيبين
+
+930
+01:30:17,100 --> 01:30:22,400
+بشكل قوي كثير وعلى سن الـ 12، 14 سنة الطفل بموت
+
+931
+01:30:22,400 --> 01:30:27,310
+لأنه بيصير عنده Respiratory Failure البكرإبارة عن
+
+932
+01:30:27,310 --> 01:30:32,030
+نوع ثاني برضه نفس الشيء في نفس الـ Protein بس درجة
+
+933
+01:30:32,030 --> 01:30:38,650
+أخف، فبيبدأ بشكل متأخر وبيكون بيعيشوا مدة أطول،
+
+934
+01:30:38,650 --> 01:30:45,310
+ماشي فبرضه هنا، هاي إمرأة زوجت رجلين في مرحلتين في
+
+935
+01:30:45,310 --> 01:30:52,890
+حياتها فبرضه جابت ولاد بهذا الشكل الملاحظ، هذون،
+
+936
+01:30:52,890 --> 01:31:00,130
+يعني هاي Autosomalماشي «dominant» هنا لأنه «مالس»
+
+937
+01:31:00,130 --> 01:31:05,790
+بس مافيش «females» affected والـ «female» يعني لما
+
+938
+01:31:05,790 --> 01:31:10,330
+أنا جيت درستها كان فيها «no mutation» لما بدي بدرس
+
+939
+01:31:10,330 --> 01:31:15,370
+أنا والله باخد الدم عادة «peripheral blood» وببحث
+
+940
+01:31:15,370 --> 01:31:20,010
+الجينات فيها ما أخدت الـ «ovary» تبع هذه المرأة
+
+941
+01:31:20,010 --> 01:31:23,750
+ولا أخدت الـ «testicle tissue» تبع هذا الرجل حتى
+
+942
+01:31:23,750 --> 01:31:24,870
+أشوف الـ mutation
+
+943
+01:31:28,240 --> 01:31:33,260
+الـ Mutation في الـ Somatic tissues مش موجود يعني
+
+944
+01:31:33,260 --> 01:31:40,420
+في الأنسج العادية زي الدم بينما لو روحنا على الـ
+
+945
+01:31:40,420 --> 01:31:44,020
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+946
+01:31:44,020 --> 01:31:44,200
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+947
+01:31:44,200 --> 01:31:46,240
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+948
+01:31:46,240 --> 01:31:46,820
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+949
+01:31:46,820 --> 01:31:47,780
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+950
+01:31:47,780 --> 01:31:49,000
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+951
+01:31:49,000 --> 01:31:49,020
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+952
+01:31:49,020 --> 01:31:53,280
+الـ الـ الـ الـ الـ الـ الـ الـ
+
+953
+01:31:53,280 --> 01:31:59,130
+الـفهذه ظاهرة موجودة وأحيانًا بلاقي عائلات بهذا
+
+954
+01:31:59,130 --> 01:31:59,530
+الشكل
+
+955
+01:32:03,250 --> 01:32:08,390
+فدكتور، في كريم بيسأل، بيقول يعني أجيت إحنا لو
+
+956
+01:32:08,390 --> 01:32:11,530
+رجعنا في شجرة العائلة بنقول فلان أخد المرض من أبوه
+
+957
+01:32:11,530 --> 01:32:15,070
+مثلا و أبوه أخده من جده، لكن الطفرة الأساسية اللي
+
+958
+01:32:15,070 --> 01:32:19,450
+عملت كل هاد هي طفرة جنسية زي اللي أنت يعني حكيت
+
+959
+01:32:19,450 --> 01:32:24,450
+عنها بتسير يعني خلال اللي هو الانقسام تبع الخلايا،
+
+960
+01:32:24,450 --> 01:32:28,070
+يعني هي اللي بتسبب إن المرض يبدأ ويتم توارثه عبر
+
+961
+01:32:28,070 --> 01:32:36,860
+الأجيالأه بس لازم حتى تحدث بهذا الشكل أنه تكون فيه
+
+962
+01:32:36,860 --> 01:32:43,560
+حتى تقدر تكمل وتبيّل ماشي يعني هنا لما أشوف عيلي
+
+963
+01:32:43,560 --> 01:32:51,060
+بهذا الشكل شايف عليه يعني و جيت أنا عارف وين
+
+964
+01:32:51,060 --> 01:32:56,780
+التفرسة عارفها وين هي وشايفها وين هي واجي أدرس
+
+965
+01:32:56,780 --> 01:33:05,400
+الأبفي الحالة هذه ولاقي مش ماعنجوش، شو بدي أقول؟
+
+966
+01:33:05,400 --> 01:33:10,960
+ممكن واحد يقول يمكن هو مش أبوهم يعني إن النسوان
+
+967
+01:33:10,960 --> 01:33:17,100
+هدول أبصر انشوا عملات وهذا هو مش الأب لهذه الأطفال
+
+968
+01:33:17,100 --> 01:33:22,920
+مثلا، ممكن هذا يكون ظاهر، بس الفكرة إنه أنا لما
+
+969
+01:33:22,920 --> 01:33:27,560
+اندورت على الـMutation في هذه الحالةدورت في الـ
+
+970
+01:33:27,560 --> 01:33:33,620
+Peripheral Blood ماشي فأنا دورت في الدم الدم مش هو
+
+971
+01:33:33,620 --> 01:33:38,060
+اللي بعطي الـ Spare ولا اللي بعطينا الـ Ova اللي
+
+972
+01:33:38,060 --> 01:33:44,060
+هي لها دخل في نقل الصفة الوراثية فاهم عليك؟ يعني
+
+973
+01:33:44,060 --> 01:33:48,000
+هو الفكرة اللي بدي بقولولك إياها إنه أنا ممكن
+
+974
+01:33:48,000 --> 01:33:54,700
+تجيني إشي زي هيك بقول Hi بما إنه سائد و أنا عارف
+
+975
+01:33:54,700 --> 01:34:01,220
+إنه سائدإذا الأب لازم كان يكون مصاب فإذا أنا دورت
+
+976
+01:34:01,220 --> 01:34:07,260
+بشكل سطحي وسريع وبالـ blood بس بلاقي إنه مثلا ممكن
+
+977
+01:34:07,260 --> 01:34:11,560
+مايلاقيش إشي وبالتالي أدخل في مشكلة عشان بدي أحاول
+
+978
+01:34:11,560 --> 01:34:17,620
+أفسر بينما لو أخدت منه من الـ testicle tissue ولا
+
+979
+01:34:17,620 --> 01:34:24,170
+cells أو أخدت الـ sperms تبعينه ودرستهمبلاقي فعلًا
+
+980
+01:34:24,170 --> 01:34:27,510
+وقتها الـ mutation موجودة فاهم عليك كده؟ فهذه
+
+981
+01:34:27,510 --> 01:34:31,770
+النقطة اللي بدنا نذكرها هنا أنه أحيانًا أنه يعني
+
+982
+01:34:31,770 --> 01:34:38,150
+الأمر متظامن الـ dominant و الـ recessive و الـ X
+
+983
+01:34:38,150 --> 01:34:41,610
+-linked و الـ dominant و الـ recessive كل هذه
+
+984
+01:34:41,610 --> 01:34:47,610
+الظواهر هي بشكل عام مبدأي فما نقعدي أخد individual
+
+985
+01:34:47,610 --> 01:34:57,250
+families individualيعني كاسد بدي أكون حذر أكتر أنه
+
+986
+01:34:57,250 --> 01:35:02,390
+ما تكون صارت أنتي شغل زي هيه أن بعض خلايا الإنسان
+
+987
+01:35:02,390 --> 01:35:07,770
+هذا طبيعية وبعضهم mutated فحسب إذا ال mutation هذه
+
+988
+01:35:07,770 --> 01:35:12,910
+في ال testicles وفي ال ovaries رح ينتج عنها أنه
+
+989
+01:35:12,910 --> 01:35:17,790
+أنا ممكن مالاقيش الاشي اللي بدور عليه فمعليك
+
+990
+01:35:20,510 --> 01:35:26,130
+فاهمين كيف يعني أن الأمر أحيانًا معقد وبدي الواحد
+
+991
+01:35:26,130 --> 01:35:35,230
+ينتبه يعني قبل خصوصًا يعني بالذات يعني أشياء زي
+
+992
+01:35:35,230 --> 01:35:38,810
+هيك ممكن واحد يصير شك هذا أبوي ولا مش أبوي مثلًا
+
+993
+01:35:38,810 --> 01:35:45,620
+يعني أشي زي هيك يعني الوخصوصًا يعني ممكن تسير
+
+994
+01:35:45,620 --> 01:35:51,560
+وراها جرائم ممكن تسير حوادث قتل يعني إش إذا الواحد
+
+995
+01:35:51,560 --> 01:35:59,900
+مثلًا بيدعي فيه إنه إشي مش سليم أو كذا يعني ممكن
+
+996
+01:35:59,900 --> 01:36:03,870
+يكون إشي خطير يعنيولمّا واحد يدرس المادة الوراثية
+
+997
+01:36:03,870 --> 01:36:07,570
+ويدور على الـ Genetic Mutation ولا يدرس بـ Degree
+
+998
+01:36:07,570 --> 01:36:13,050
+وكذا، يكون دقيق بس يكون متنبه لكل الاحتمالات
+
+999
+01:36:13,050 --> 01:36:18,130
+وأحيانًا الـ Lethal Genes داهرة بتخربط لك النسب
+
+1000
+01:36:18,130 --> 01:36:24,010
+وبتخلي أشياء تكون طريقة مختلفة أو إنه Mutation في
+
+1001
+01:36:24,010 --> 01:36:28,210
+جزء من الخلايا، مش في كل الخلاياوإذا جزء من
+
+1002
+01:36:28,210 --> 01:36:32,270
+الخلايا إذا من الجزء اللي ممكن ينتقل بختلف عن جزء
+
+1003
+01:36:32,270 --> 01:36:36,970
+اللي لا يمكن أن ينتقل يعني لو شاء موجود فحسب أنت
+
+1004
+01:36:36,970 --> 01:36:41,370
+على وين بتدور على إيش بتدور بتطلعلك النتيجة وبدك
+
+1005
+01:36:41,370 --> 01:36:43,850
+تقراها بشكل سريع ماشي
+
+1006
+01:36:49,070 --> 01:36:55,470
+هنا برضه يعني برضه بـ degree Paraganglioma
+
+1007
+01:36:55,470 --> 01:37:02,910
+Syndrome I من الأمراض ودائماً SDHD الـ Capital
+
+1008
+01:37:02,910 --> 01:37:07,350
+Letter هو اللي يعني الـ Gen بدي يكون بيأشر على
+
+1009
+01:37:07,350 --> 01:37:13,750
+البروتين اللي دخل فهنا درسوا عائلة معينة وشافوا
+
+1010
+01:37:13,750 --> 01:37:20,460
+يعني لما أنا شوفت حاجة زي هيكأول شيء اللي affected
+
+1011
+01:37:20,460 --> 01:37:28,500
+males و females فهذا يعني بدي تكون شو اسمه قضية
+
+1012
+01:37:28,500 --> 01:37:40,140
+تكون يعني X-linked أتزامل يعني إنه مش مش قضية X
+
+1013
+01:37:40,140 --> 01:37:45,080
+-linked يعني لأنه فيه males فيه فيه فيه females و
+
+1014
+01:37:45,080 --> 01:37:50,010
+فيه males مصابين فهي يعني ناحيةباتعقد الموضوع،
+
+1015
+01:37:50,010 --> 01:37:55,170
+فهذا بيفرجيكم درجات تعقيد الموضوع هذا من الأمراض
+
+1016
+01:37:55,170 --> 01:38:01,530
+المهمة كثير وهي autosomal dominance قضية الـ
+
+1017
+01:38:01,530 --> 01:38:08,470
+Huntington's disease ماعرفش إذا بتعرفوا عنه يسموها
+
+1018
+01:38:08,470 --> 01:38:13,790
+مرات Huntington's Korea حد
+
+1019
+01:38:13,790 --> 01:38:18,200
+بعرف إيش عن هذا المرض؟مرض Huntington اسم الزلمي
+
+1020
+01:38:18,200 --> 01:38:23,400
+هذا اللي وصفه يعني
+
+1021
+01:38:23,400 --> 01:38:32,660
+هو مرض صراحة مشكلته إنه مرض مرعب يعني الفكرة
+
+1022
+01:38:32,660 --> 01:38:39,000
+أحياناً الأمراض الوراثية خصوصاً اللي بتصير بعدين
+
+1023
+01:38:39,000 --> 01:38:45,990
+شديدة وبتكون قاتلة ويعني بتأثر على الإنسانفيه يبدو
+
+1024
+01:38:45,990 --> 01:38:50,450
+إنه عندهم معرفة مخصوص لنوضوع يمكن من الـBio فيه
+
+1025
+01:38:50,450 --> 01:38:53,050
+بيقولوا إنه تراكم الحمض الأميني Glutamate و
+
+1026
+01:38:53,050 --> 01:38:57,370
+mutation في amino acid وبيظهر بعد سن الأربعين على
+
+1027
+01:38:57,370 --> 01:38:59,930
+ما أتجابلها ما بتكون ظاهرة بشكل واضح يعني كل هذه
+
+1028
+01:38:59,930 --> 01:39:05,970
+المعلومات طرحوها نعم ماشي فهي الفكرة يعني إن مرض
+
+1029
+01:39:05,970 --> 01:39:12,570
+يسبب الشلل ويسبب عدم القدرة على الحركة وعلى التنفس
+
+1030
+01:39:12,570 --> 01:39:20,650
+والوفاة المبكرةبس عادة الأمراض الوراثية يعني الناس
+
+1031
+01:39:20,650 --> 01:39:26,970
+بالذات لما يظهر المرض على عمر مبكر بيجوزوش المصاب،
+
+1032
+01:39:26,970 --> 01:39:31,950
+بيخلفش هذا المصاب وبالتالي يعني بالذات لما نقول
+
+1033
+01:39:31,950 --> 01:39:38,750
+autosomal dominant بتلاقي أنه يعني بيظل المصدر
+
+1034
+01:39:38,750 --> 01:39:44,570
+الرئيسي للمرض هو تفرات جديدة يعني بتحدث بين الناس
+
+1035
+01:39:45,110 --> 01:39:51,530
+ماشي لسبب أو لآخر أشعاع كيمويات أمراض فيروسية إشي
+
+1036
+01:39:51,530 --> 01:39:57,590
+بيخلص بسبب فترة يعني فالـ Huntington مشكلته إنه
+
+1037
+01:39:57,590 --> 01:40:02,670
+بيبدأ على سن الأربعين مثلا فالمشكلة لما نيبدأ على
+
+1038
+01:40:02,670 --> 01:40:08,090
+سن الأربعين إنه في الغالب بتلاقي الإنسان على سن
+
+1039
+01:40:08,090 --> 01:40:14,630
+العشرين تذكر ولا قلت اتزوج و جاب ولاد و بنادوبعدين
+
+1040
+01:40:14,630 --> 01:40:18,990
+بيبقى معاه المرض فهذه مشكلته عيبه يعني بالنسبة لما
+
+1041
+01:40:18,990 --> 01:40:24,130
+يعني عائلة تنتبه أو شخص ينتبه أن والده عنده مشكلة
+
+1042
+01:40:24,130 --> 01:40:31,450
+Huntington's الـ Huntington's مشكلته أنه بيجيك
+
+1043
+01:40:31,450 --> 01:40:37,650
+إنسان مثلا شاف معاناة والده أو والدته في المرض هذا
+
+1044
+01:40:37,650 --> 01:40:43,980
+وعارف أنه مرض وراثي سائديعني إذا نسخة واحدة خلاص
+
+1045
+01:40:43,980 --> 01:40:52,780
+الإنسان مصاب وتلاقي يعني هنا قضية الـ Age of onset
+
+1046
+01:40:52,780 --> 01:41:01,040
+يعني بيحاولوا يظهروها إنه كل ما نزلنا لتحت بيكون
+
+1047
+01:41:01,040 --> 01:41:07,280
+العمر اللي بتبين فيه المشكلة بشكل أصغر يعني بيكون
+
+1048
+01:41:07,280 --> 01:41:12,930
+إنسان بيظهر عليه المشكلةفهي الفكرة إنه بظهر بشكل
+
+1049
+01:41:12,930 --> 01:41:18,510
+متأخر يعني بعد ما الإنسان بيكون عائلته بيجيب ولاده
+
+1050
+01:41:18,510 --> 01:41:24,330
+بنات وكذا وبعدين بيشوف المرض والمعاناة في كثير من
+
+1051
+01:41:24,330 --> 01:41:28,450
+الناس في الحالات الوراثية تمامًا راح نأخذ بعدين عن
+
+1052
+01:41:28,450 --> 01:41:32,970
+الـGenetic Counseling وكيف تنصح وشو تنصح الأهل
+
+1053
+01:41:32,970 --> 01:41:41,370
+وكذا فالفكرة بتكون إنه الأحيانلما يجيك إنسان ويكون
+
+1054
+01:41:41,370 --> 01:41:47,350
+عنده عند والده أو والدته مثل هيك مرض ويصير هو يسأل
+
+1055
+01:41:47,350 --> 01:41:52,670
+طب شو وضعي أنا أتزوج أجيب ولاد وبنات يصير عندهم
+
+1056
+01:41:52,670 --> 01:41:57,610
+المرض ولا أقفع النسل وماسويش إشي في ناس أحياناً
+
+1057
+01:41:57,610 --> 01:42:03,820
+بنتحروا في ثقافات وفي مجتمعات وكذابتلاقيهم
+
+1058
+01:42:03,820 --> 01:42:09,560
+باعتمدوا على إنه إنك انت تدرس الـMutation وتشوف
+
+1059
+01:42:09,560 --> 01:42:17,000
+موجودة، مش موجودة وهنا شكله الـ الـ الها فيه
+
+1060
+01:42:17,000 --> 01:42:20,960
+repeats معينة في منطقة معينة هي بتكون الـColony
+
+1061
+01:42:20,960 --> 01:42:30,040
+إنه الـHD-Gene الـHuntington Disease Geneبتلاقي في
+
+1062
+01:42:30,040 --> 01:42:35,460
+قطعة معينة تتكرر بنسب معين حسب الـ copies وتعتمد
+
+1063
+01:42:35,460 --> 01:42:40,060
+حسب العدد يعني كل ما زاد عدد الـ copies من الـ
+
+1064
+01:42:40,060 --> 01:42:46,680
+inserts هدولة يعني 100، 100، 110، بتلاقي الـage of
+
+1065
+01:42:46,680 --> 01:42:52,940
+inserts صغير كثير وبيكون الإنسان بيظهر على عمر
+
+1066
+01:42:52,940 --> 01:42:59,750
+أصغر بينما لو قلت عدد الجيناتالنسخ هذه ممكن يتأخر
+
+1067
+01:42:59,750 --> 01:43:07,230
+بسن الخمسين أو ستين يعني هاي القصد في الموضوع إن
+
+1068
+01:43:07,230 --> 01:43:13,650
+هي من أمثلة أهمية تشخيص الـMutation بشكل دقيق
+
+1069
+01:43:13,650 --> 01:43:18,870
+لأنه، وبدك تكون على جد حالك كمختبر تدرس
+
+1070
+01:43:18,870 --> 01:43:24,510
+الـMutation، تشوف اللي موجود عند الأب والأموش اللي
+
+1071
+01:43:24,510 --> 01:43:28,630
+موجود عند هذا الإنسان حتى تنصحه بشكل سليم أو بشكل
+
+1072
+01:43:28,630 --> 01:43:34,410
+يكون منطقي أما اللي هو من الأمراض الحقيقة يعني
+
+1073
+01:43:34,410 --> 01:43:40,150
+ورافياً مرعبة من ناحية أخلاقية يعني شو أعمل مع
+
+1074
+01:43:40,150 --> 01:43:47,670
+الإنسان هذا؟ هيكون الإنسان قلق ومتوتر وبتلاقي مخه
+
+1075
+01:43:47,670 --> 01:43:52,330
+بضرب أخماس بستاس ويصير يفكر شو أعمل وكذاوخصوصًا
+
+1076
+01:43:52,330 --> 01:43:57,930
+لما تشوف معاناة إنسان مصاب بالمرض فهو مثال على
+
+1077
+01:43:57,930 --> 01:44:07,030
+برضه يعني بحث طريقة أخرى للـ Huntington's disease
+
+1078
+01:44:07,030 --> 01:44:09,990
+بس يعني بدنا نتذكر الـ Huntington's disease هو
+
+1079
+01:44:09,990 --> 01:44:17,390
+كظامل dominant يعني one copy is enough وبتكون يعني
+
+1080
+01:44:17,390 --> 01:44:26,450
+بتسببيعني stress كتير على العائلة وعلى المجتمع في
+
+1081
+01:44:26,450 --> 01:44:34,510
+حالتها ال .. ال .. في أمراض تانية ماشي إحنا مش
+
+1082
+01:44:34,510 --> 01:44:43,410
+هدفنا ال .. ال .. يعني so far اللي كان الهدف تبعنا
+
+1083
+01:44:43,410 --> 01:44:50,760
+هي قضية أنواع ال inheritance ومشاكلهابالذات كـ
+
+1084
+01:44:50,760 --> 01:44:56,460
+Autosomal و X-Link وفيه Dominant وRecessive وبدك
+
+1085
+01:44:56,460 --> 01:45:00,900
+تتذكر يعني بكل الأمور هذه إنه إحنا بنتكلم على
+
+1086
+01:45:00,900 --> 01:45:06,120
+Single Gene Disease ما بنتكلم على قطعة كبيرة زي
+
+1087
+01:45:06,120 --> 01:45:11,340
+الـChromosome ولا قطعة أصغر من الـChromosome bands
+
+1088
+01:45:11,340 --> 01:45:16,110
+معينةزي الـ Digorre Syndrome لأ، احنا هنا بنتكلم
+
+1089
+01:45:16,110 --> 01:45:21,190
+على مرض المسئول عنه جين واحد بس ويكون فيه مشكلة
+
+1090
+01:45:21,190 --> 01:45:25,410
+معينة النقطة
+
+1091
+01:45:25,410 --> 01:45:29,990
+الأخيرة، مثال الأخير اللي حاطينه هنا بد الواحد
+
+1092
+01:45:29,990 --> 01:45:35,970
+يتذكر 3% من الـDNA في الخلايا في الـMitochondria
+
+1093
+01:45:35,970 --> 01:45:40,390
+مش في الـNucleus، مش في الـChromosomesطبعاً الـ
+
+1094
+01:45:40,390 --> 01:45:45,910
+autosomal والـ X-link، الـ X والـ Y، الـPair ففيه
+
+1095
+01:45:45,910 --> 01:45:49,650
+إنا إشي اسمه mitochondrial disease «ميوتوكندريا
+
+1096
+01:45:49,650 --> 01:45:51,890
+الإنهيريتس» «ميوتوكندريا الإنهيريتس» هاي الشغل بدي
+
+1097
+01:45:51,890 --> 01:45:58,530
+الواحد يظل يذكرها وبتكون الـ زي هنا المثال «Lipids
+
+1098
+01:45:58,530 --> 01:46:03,430
+Hereditary Pycneopathy» كمثال حاطين عليه 3% من
+
+1099
+01:46:03,430 --> 01:46:07,740
+الجينات بتكون في الـ mitochondriaبالذات الجينات
+
+1100
+01:46:07,740 --> 01:46:11,120
+اللي تستخدم جوا الـ Mitochondria اللي هي فرن
+
+1101
+01:46:11,120 --> 01:46:16,900
+الطاقة في الـ Krebs Cycle و الـ Glycolysis و
+
+1102
+01:46:16,900 --> 01:46:21,400
+الأشياء اللي هي بتطلع الـ ATP كمركب الطاقة في
+
+1103
+01:46:21,400 --> 01:46:26,900
+الخلية فالـ Mitochondrial Diseases ماشي اللي هي
+
+1104
+01:46:26,900 --> 01:46:32,440
+مثال عليها هذا المرض اللي هي Adult Onset Blindness
+
+1105
+01:46:32,440 --> 01:46:38,780
+يعني بيصير واحد عندهفشل في البصر وبيكون مع العمر
+
+1106
+01:46:38,780 --> 01:46:47,520
+متأخر وبيقول زي ما انتوا شايفين هنا الـ males و ال
+
+1107
+01:46:47,520 --> 01:46:53,140
+females can be affected بس بدك تتذكر انه ال
+
+1108
+01:46:53,140 --> 01:46:58,300
+mitochondria ما بتنتقل الا في ال ovaries ال spare
+
+1109
+01:46:58,300 --> 01:47:03,340
+مش فيها mitochondria فالانتقال بيكون عن طريق ال
+
+1110
+01:47:03,340 --> 01:47:09,580
+eggsالـ Females للـ Ovaries لما أنا أجى أشوف مثلا
+
+1111
+01:47:09,580 --> 01:47:18,520
+هذا الجزء أول شي بقول أنه autosomal شو اسمه؟ بقول
+
+1112
+01:47:18,520 --> 01:47:23,340
+أنه يعني هاي ال males و ال females are affected
+
+1113
+01:47:23,340 --> 01:47:29,760
+ماشي و هاي كل ال generation عادة affected يعني هيك
+
+1114
+01:47:29,760 --> 01:47:37,640
+بشوفها بشكل سريع ف .. بس الملاحظةإنه ما في، لو
+
+1115
+01:47:37,640 --> 01:47:43,320
+male affected ما في إحدى من ذريته مصاب يعني أنا
+
+1116
+01:47:43,320 --> 01:47:48,900
+أشوف هذا ال male وكل اللي عنده ذكور أو إنات وأكتر
+
+1117
+01:47:48,900 --> 01:47:53,300
+من generation ومش عارف إيش، مش حدا مصاب بينما هذه
+
+1118
+01:47:53,300 --> 01:47:59,920
+الأنتة نقلتها لولادها وبناتها الأولاد برضه زي ال
+
+1119
+01:47:59,920 --> 01:48:07,070
+.. زي هو نعم كالهم ماشيما تقدرش ينقل لولاده وبناته
+
+1120
+01:48:07,070 --> 01:48:11,930
+الولد المُصاحب بينما الـ Female تنقل لولاده
+
+1121
+01:48:11,930 --> 01:48:16,350
+والبنات لما نشوف حاجة زي هيك فهي Mitochondrial
+
+1122
+01:48:16,350 --> 01:48:23,530
+Inheritance إن الـ Inheritance through الـ Female
+
+1123
+01:48:23,530 --> 01:48:29,410
+lineage بس الأم أو الأنثى هي اللي تقدر تنقل المرض
+
+1124
+01:48:29,410 --> 01:48:34,210
+لولادها وبناتها، دكور وإنان، ما في فرصةوإنما
+
+1125
+01:48:34,210 --> 01:48:38,190
+الأولاد المصابين أو الذكور المصابين ما بيقدروا
+
+1126
+01:48:38,190 --> 01:48:42,330
+ينقلوا هذه المرضى أو هذه الحالة زي Adult-onset
+
+1127
+01:48:42,330 --> 01:48:45,090
+blindness اللي هو Liberis Hereditary of
+
+1128
+01:48:45,090 --> 01:48:50,490
+Technopathy كمثال على Mitochondrial DNA Disease
+
+1129
+01:48:50,490 --> 01:48:56,150
+Inherited فهذه ناحية مهمة وهي كمان من التعقيد في
+
+1130
+01:48:56,150 --> 01:49:01,150
+الظواهر اللي أحيانًا لازم تقدر تختمها عشان أفسر
+
+1131
+01:49:01,150 --> 01:49:05,740
+بعض العائلات و بعض الحالاتوالله يعطيكم العقل في حد
+
+1132
+01:49:05,740 --> 01:49:11,040
+عنده أسئلة؟
+
+1133
+01:49:11,040 --> 01:49:14,380
+يعني
+
+1134
+01:49:14,380 --> 01:49:19,340
+ما حتسأل لحد دي الآن إن شاء الله إذا إن شاء الله
+
+1135
+01:49:19,340 --> 01:49:25,460
+نتلاقى بعد بكرة ونتكلم إن شاء الله بخصوص الـ… إيش
+
+1136
+01:49:25,460 --> 01:49:28,400
+اسمها يا دكتور؟ بخصوص الأسئلة بقى أتواصل معاك إن
+
+1137
+01:49:28,400 --> 01:49:34,050
+شاء الله ونتفقد على أقل إحنا شوفأنا بظن إنه مع
+
+1138
+01:49:34,050 --> 01:49:41,930
+نهاية الcourse إن شاء الله زي كـPlan، كأسئلة أظن
+
+1139
+01:49:41,930 --> 01:49:46,910
+فيها 400 سؤال، هيك شفت على خير بس المشكلة يعني أنا
+
+1140
+01:49:46,910 --> 01:49:51,890
+مش قادر أو مش هنكون قادرين على إنه ندخل في تفاصيل
+
+1141
+01:49:51,890 --> 01:49:59,180
+كل الأمراض وكل الحالات وكذاببتنا المبادئ والواحد
+
+1142
+01:49:59,180 --> 01:50:03,520
+يكون عنده إمكانية ترجع لمرجع مناسب بحيث يأخذ
+
+1143
+01:50:03,520 --> 01:50:08,400
+معلومة تقوده في كيف يتعامل مع الحالة، إن شاء الله
+
+1144
+01:50:08,400 --> 01:50:12,540
+طيب وبخصوص ورقة العمل بيبقى هنا تواصل على القليل
+
+1145
+01:50:12,540 --> 01:50:16,240
+اللي يتم توصفه إن شاء الله، إن شاء الله، أهلا و
+
+1146
+01:50:16,240 --> 01:50:18,760
+سهلا، يالا السلام عليك، مع السلامة
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/ecLGirzn8pc_raw.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/ecLGirzn8pc_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..0c1d422fdfde9b074aea61a47e834f14dba10edc
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/ecLGirzn8pc_raw.srt
@@ -0,0 +1,6220 @@
+1
+00:00:00,000 --> 00:00:06,380
+إن شاء الله يعني كمعلومة للطلاب
+
+2
+00:00:06,380 --> 00:00:10,240
+إحنا إن شاء الله راح يكون جزء الأخير بنشوف آلية
+
+3
+00:00:10,240 --> 00:00:15,100
+كويسة نراجع فيها الأسئلة تبع الـUSMLE وCAPLAN
+
+4
+00:00:15,100 --> 00:00:22,060
+والمراجع اللي هي نوع معين international على أساس
+
+5
+00:00:22,060 --> 00:00:28,680
+يعني هو هذا معيار اللي نغطينا المادة إن شاء الله
+
+6
+00:00:28,680 --> 00:00:37,170
+نكوناستوعبته واستفدنا إن شاء الله الآن،
+
+7
+00:00:37,170 --> 00:00:43,150
+نحن ماشي لسه في الكتاب، ماضلش غير فصل أو فصلين بعد
+
+8
+00:00:43,150 --> 00:00:51,130
+ذلك، يعني بالذات بعتبر الـ Ethics تبع الـ Genetic
+
+9
+00:00:51,130 --> 00:00:55,690
+Counseling أو الاشي اللي بنعملها فيه جوانب أخلاقية
+
+10
+00:00:55,690 --> 00:01:00,500
+مهمة كثير، وهي أنا بعتبر مهمة من الواحديتناولها،
+
+11
+00:01:00,500 --> 00:01:06,280
+يعني هي بتظل محاضرة أو محاضرتين بعد اليوم وبعد ذلك
+
+12
+00:01:06,280 --> 00:01:14,500
+راح تكون نوع من مراجعة الأسئلة الآن
+
+13
+00:01:14,500 --> 00:01:20,640
+اليوم محاضرتين هما قريبات على بعض وقصيرات نوعًا ما
+
+14
+00:01:20,640 --> 00:01:24,040
+نتعامل
+
+15
+00:01:24,040 --> 00:01:31,660
+مع كيف بدنا نتعامليعني، ما هي الأليات؟ ما هي
+
+16
+00:01:31,660 --> 00:01:37,920
+الخطوات التي يجب أن تكون جهة معينة مسئولة في
+
+17
+00:01:37,920 --> 00:01:44,700
+الحكومة، في البلد أو في مستشفى تتعامل مع كيف ننصح
+
+18
+00:01:44,700 --> 00:01:50,080
+الأهالي والعائلات لما نكون عندنا احتمالية أمراض
+
+19
+00:01:50,080 --> 00:01:56,800
+ورافيةالآن فيه Two Chapters Today فيه Risk
+
+20
+00:01:56,800 --> 00:02:00,440
+Assessment وGenetic Counseling يعني شو بدنا نعمل
+
+21
+00:02:00,440 --> 00:02:05,260
+في الموضوع هذا وبعد ذلك في محاضرة اللي بعدها اللي
+
+22
+00:02:05,260 --> 00:02:11,380
+هي نسمينها Preterm أو Prenatal Diagnosis اللي هو
+
+23
+00:02:11,380 --> 00:02:19,840
+تشخيص ما قبل الولادة يعني حتى إذا في خيار أنه تعمل
+
+24
+00:02:19,840 --> 00:02:27,020
+علاجات معينة أنه نعملهافاليوم المحاضرة الأولى هي
+
+25
+00:02:27,020 --> 00:02:35,700
+على شو نعمل مع عائلة عندها احتمالية مرض وراثي شو
+
+26
+00:02:35,700 --> 00:02:40,280
+ننصحها، كيف ننصحها، على أي أساس ننصحها وكيف نتعامل
+
+27
+00:02:40,280 --> 00:02:45,100
+مع الموضوع هذا النقطة
+
+28
+00:02:45,100 --> 00:02:55,240
+الأولى يعني حاطين هنا ما يمثلقواعد عامة في التعامل
+
+29
+00:02:55,240 --> 00:02:59,200
+مع الـ Genetic Diseases
+
+30
+00:03:03,670 --> 00:03:08,170
+قسموا العائلة، يعني ممكن أي إنسان يكون عنده هيك
+
+31
+00:03:08,170 --> 00:03:12,830
+إذا بيشوف حد من أقاربه عنده حالة ورافية، ممكن هو
+
+32
+00:03:12,830 --> 00:03:17,510
+يتساءل جوا نفسه إنه هل أنا معرض أو أصاب بنفس المرض
+
+33
+00:03:17,510 --> 00:03:24,670
+بنفس الطريقة أو إذا عائلة أو زوجين عندهم واحد أو
+
+34
+00:03:24,670 --> 00:03:31,350
+في العائلة عندهم في مرض معين، بتكون يعني الواحد
+
+35
+00:03:31,350 --> 00:03:36,550
+هيك يقدرفهنا كقاعدة
+
+36
+00:03:36,550 --> 00:03:41,490
+عامة، خلّيني نخد بالآخر، بالأول والآخر واحدة تحت
+
+37
+00:03:41,490 --> 00:03:46,890
+كتبيلكم الـ Average Risk الإنسان العادي، يعني إحنا
+
+38
+00:03:46,890 --> 00:03:50,890
+قررنا عن أمراض كثيرة، بيصير الواحد أصلا مخه يلف
+
+39
+00:03:50,890 --> 00:03:55,030
+ويفكر إنه عنده واحد من هذه الأشياء أو ممكن يصيبه
+
+40
+00:03:55,030 --> 00:03:59,730
+أو ممكن يصيب ولاده ولا كده فالـ Average Risk اللي
+
+41
+00:03:59,730 --> 00:04:03,480
+هي زي الـ Risk in the general populationعندما يكون
+
+42
+00:04:03,480 --> 00:04:07,360
+هناك مصادر غير مصادر مصادر مصادر مصادر مصادر مصادر
+
+43
+00:04:07,360 --> 00:04:09,820
+مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر
+
+44
+00:04:09,820 --> 00:04:12,860
+مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر
+
+45
+00:04:12,860 --> 00:04:14,240
+مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر
+
+46
+00:04:14,240 --> 00:04:17,180
+مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر
+
+47
+00:04:17,180 --> 00:04:18,020
+مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر
+
+48
+00:04:18,020 --> 00:04:28,830
+مصادر مصادر مصادر مصادر مصادر مصادر مصاديعني هذه
+
+49
+00:04:28,830 --> 00:04:34,830
+نفس المعنى مش عارف ليش يعني بيحطها تكرار بس
+
+50
+00:04:34,830 --> 00:04:39,790
+التنتين بتعني إنه واحد ما عنده مثل هي حالة لما تصل
+
+51
+00:04:39,790 --> 00:04:44,990
+الأمور إلى إنه second degree relative يعني إنسان
+
+52
+00:04:44,990 --> 00:04:55,410
+ابن عم أو عم أو حدا بعيد أبعد شوية وشخص واحد بس
+
+53
+00:04:55,410 --> 00:05:01,260
+يعني مش عداد أكبربكون هذا الاحتمالية تعتبر يعني مش
+
+54
+00:05:01,260 --> 00:05:04,760
+أكتر من الـ General Population بشكل عام و هنشوف
+
+55
+00:05:04,760 --> 00:05:08,780
+أمثلة عليها أو في حالة ما بيصير عملية تبني
+
+56
+00:05:08,780 --> 00:05:15,660
+فالإنسان المتبنى ما له علاقة بالـ يعني بالما هو
+
+57
+00:05:15,660 --> 00:05:20,500
+معلوم عن العائلة من وجود أمراض وراثية فهذولة
+
+58
+00:05:20,500 --> 00:05:25,960
+Average Risk في المقابل الـ
+
+59
+00:05:27,710 --> 00:05:34,690
+عنا الـ group بتكون high risk إذا كان عندنا first
+
+60
+00:05:34,690 --> 00:05:40,210
+degree relative قريب من الدرجة الأولى وعرفناهم من
+
+61
+00:05:40,210 --> 00:05:45,310
+قبل اللي هم يعني الأب والأم والإخوان والولادة
+
+62
+00:05:45,310 --> 00:05:50,250
+والبنات، لأي واحد حوالينه أبعد من هيك بيصير second
+
+63
+00:05:50,250 --> 00:05:56,230
+degree وأبعد من ذلك third degreeفلما يكون الـ
+
+64
+00:05:56,230 --> 00:06:03,630
+First degree relative ماشي وتكون Early يعني بالذات
+
+65
+00:06:03,630 --> 00:06:09,670
+إذا المرض بيبين على عمره صغير إذا في عندنا أثنين
+
+66
+00:06:09,670 --> 00:06:14,450
+affected first degree relatives هذه high risk one
+
+67
+00:06:14,450 --> 00:06:18,710
+first degree relative with late or unknown disease
+
+68
+00:06:18,710 --> 00:06:24,770
+onsetوشخصين من الجامعة الأولى والأولى وشخصين من
+
+69
+00:06:24,770 --> 00:06:33,550
+الجامعة
+
+70
+00:06:33,550 --> 00:06:37,250
+الأولى والأولى وشخصين من الجامعة الأولى والأولى
+
+71
+00:06:37,250 --> 00:06:38,710
+وشخصين من الجامعة الأولى والأولى وشخصين من الجامعة
+
+72
+00:06:38,710 --> 00:06:40,290
+الأولى والأولى وشخصين من الجامعة الأولى والأولى
+
+73
+00:06:40,290 --> 00:06:40,510
+وشخصين من الجامعة الأولى والأولى وشخصين من الجامعة
+
+74
+00:06:40,510 --> 00:06:42,190
+الأولى والأولى وشخصين من الجامعة الأولى وشخصين من
+
+75
+00:06:42,190 --> 00:06:43,330
+الجامعة الأولى وشخصين من الجامعة الأولى وشخصين من
+
+76
+00:06:43,330 --> 00:06:43,770
+الجامعة الأولى وشخصين من الجامعة الأولى وشخصين من
+
+77
+00:06:43,770 --> 00:06:45,110
+الجامعة الأولى وشخصين من الجامعة الأولى وشخصثلاث
+
+78
+00:06:45,110 --> 00:06:47,710
+أو أكتر مصادر أو مصادر أساسي أو مصادر أساسي أو
+
+79
+00:06:47,710 --> 00:06:49,930
+مصادر أساسي أو مصادر أساسي أو مصادر أساسي أو مصادر
+
+80
+00:06:49,930 --> 00:06:51,010
+أساسي أو مصادر أساسي أو مصادر أساسي أو مصادر أساسي
+
+81
+00:06:51,010 --> 00:06:54,070
+أو مصادر أساسي أو مصادر أساسي أو مصادر أساسي أو
+
+82
+00:06:54,070 --> 00:06:58,950
+مصادر أساسي أو مصادر أساسي أو مصادر أساسي أو مصادر
+
+83
+00:06:58,950 --> 00:06:59,970
+أساسي أو مصادر أساسي أو مصادر أساسي أو مصادر أساسي
+
+84
+00:06:59,970 --> 00:07:05,250
+أو مصادر أساسي أو مصادر أساسي أو مصادر أساسي أو
+
+85
+00:07:05,250 --> 00:07:17,470
+مصادر أساسي أو مصادماشي، يعني بيكون الاحتمالية
+
+86
+00:07:17,470 --> 00:07:23,450
+أكبر وخطورة حدوث مرض وراثي أعلى جداً في حالة وجود
+
+87
+00:07:23,450 --> 00:07:30,000
+أي من هذه الحالاتمن بين، متوسط، moderate risk يكون
+
+88
+00:07:30,000 --> 00:07:33,940
+one first degree relative with late or unknown
+
+89
+00:07:33,940 --> 00:07:36,960
+onset of disease أو two second degree relative
+
+90
+00:07:36,960 --> 00:07:40,020
+from the same lineage with late or unknown disease
+
+91
+00:07:40,020 --> 00:07:47,020
+onset يعني هنا الفكرة كل ما كانت درجة القرابة أقرب
+
+92
+00:07:47,020 --> 00:07:51,530
+first degree مقارنة بsecond أو third degreeوكل ما
+
+93
+00:07:51,530 --> 00:07:57,950
+كان العمر أقل أو أصغر في بداية المرض بيكون
+
+94
+00:07:57,950 --> 00:08:02,490
+احتمالية العامل الوراثي أكبر وهذه حتى احنا شفناها
+
+95
+00:08:02,490 --> 00:08:09,450
+بالنسبة لمقارنة الـ Chromosome مع الـ Single Gene
+
+96
+00:08:09,450 --> 00:08:16,480
+Diseaseاللي هي المجموعة الثالث الـ Polygenic أو
+
+97
+00:08:16,480 --> 00:08:20,900
+Multifactorial Diseases بيصير كل ما كبر الإنسان في
+
+98
+00:08:20,900 --> 00:08:24,420
+الأمر الـ Multifactorial هم اللي أكتر والـ role أو
+
+99
+00:08:24,420 --> 00:08:30,500
+الحجم تبع الـ Genetic Diseases importance بيصير
+
+100
+00:08:30,500 --> 00:08:38,010
+أقل أقل مع تقدم الأمرفهذه مبدأ أو شيء يجب أن
+
+101
+00:08:38,010 --> 00:08:45,750
+يحكمنا ويجب أن نكون منتبهين له لأنه يجب أن يكون في
+
+102
+00:08:45,750 --> 00:08:51,030
+أي مكان نفترض في غزة و لا كذا المفروض أن يكون شخص
+
+103
+00:08:51,030 --> 00:08:57,890
+متخصص بالأمراض الوراثية وهو نوع من التخصصات غريبة
+
+104
+00:08:57,890 --> 00:09:05,590
+قليلاًفي مرات كثيرة طباء أطفال يتخصصوا بمثل هذا
+
+105
+00:09:05,590 --> 00:09:12,070
+التخصص ويدّون تدريب خاص منه على الـ Genetics ومنه
+
+106
+00:09:12,070 --> 00:09:16,890
+على الكلام اللي راح نحكيه كيف الواحد يعمل عملية
+
+107
+00:09:16,890 --> 00:09:20,350
+الـ Counseling كيف الواحد يقود العائلة بالنسبة
+
+108
+00:09:20,350 --> 00:09:29,630
+للتعامل مع حالة مرض ورافي الآن لما نيجي نشوف مين
+
+109
+00:09:31,950 --> 00:09:38,830
+الناس اللي يعني بسعوا أنه يطلبوا الـ Genetic
+
+110
+00:09:38,830 --> 00:09:44,150
+Counseling وبتلاقي يعني الـ Common Indications for
+
+111
+00:09:44,150 --> 00:09:49,470
+Genetic Counseling اللي بحتاج هذا الأمر ماشي هم
+
+112
+00:09:49,470 --> 00:09:57,030
+مجموعة يعني مش كل ال population عادة يعني بتهم هذا
+
+113
+00:09:57,030 --> 00:10:05,110
+الموضوعمرات بتلاقي يعني في حدث
+
+114
+00:10:05,110 --> 00:10:09,990
+معين أو شيء معين صار في عائلة معينة، بالتالي
+
+115
+00:10:09,990 --> 00:10:17,850
+بتخليهم يسعوا أن يحاولوا يدرسوا كام نسبة احتمالية
+
+116
+00:10:17,850 --> 00:10:23,350
+حدوث المرض الوراثي مرة أخرى أو بيطلبوا الـ
+
+117
+00:10:23,350 --> 00:10:27,540
+Counselingفإذا كان عائلة عندهم previous child with
+
+118
+00:10:27,540 --> 00:10:30,140
+multiple congenital anomalies أو intellectual
+
+119
+00:10:30,140 --> 00:10:34,640
+disabilities أو isolated birth defect أو cliff lip
+
+120
+00:10:34,640 --> 00:10:41,260
+و cliff palate يعني شخص عائلة عندها فرد مصاب بمرض
+
+121
+00:10:41,260 --> 00:10:48,140
+ورافي أو احتمال ان يكون ورافيفهنا بيصير فيه اهتمام
+
+122
+00:10:48,140 --> 00:10:52,840
+إنه طب والأطفال اللي بعد ذلك هيصيبهم، مش هيصيبهم،
+
+123
+00:10:52,840 --> 00:10:56,900
+ومش هو الاحتمالية؟ يعني في مرات ناس بيقولك خلاص،
+
+124
+00:10:56,900 --> 00:11:03,030
+بقطع الخلف وما بديشأمر في معاناة طفل مصاب ويعني دا
+
+125
+00:11:03,030 --> 00:11:09,430
+احتمالية صعبة شديدة إنه يكون يتوفى ولا كده فإنما
+
+126
+00:11:09,430 --> 00:11:16,570
+يكون في شخص مصاب في العائلة already بتلاقي يعني
+
+127
+00:11:16,570 --> 00:11:21,490
+بيكون فيه اهتمام إنه يسعوا لحصول على الاستشارة
+
+128
+00:11:21,490 --> 00:11:25,310
+الوراثية إذا في personal history أو family history
+
+129
+00:11:25,310 --> 00:11:29,100
+وhereditary conditionمثل الـ Cystic Fibrosis أو
+
+130
+00:11:29,100 --> 00:11:30,940
+الـ Fragile X Syndrome أو الـ Congenital Heart
+
+131
+00:11:30,940 --> 00:11:34,100
+Disease أو الـ Hereditary Cancer من أنواع الـ
+
+132
+00:11:34,100 --> 00:11:38,440
+cancers اللي لها ارتباط بالعائلة حكينا عن الـ
+
+133
+00:11:38,440 --> 00:11:42,340
+Retinoplastoma أو الـ Family الـ Hereditary
+
+134
+00:11:42,340 --> 00:11:47,500
+Polyposis أو الـ Coli أو فيه أشياء معينة السكري
+
+135
+00:11:47,500 --> 00:11:52,580
+أحياناً فإذا في شخص نفسه أو العائلة عنده مرض معين
+
+136
+00:11:52,920 --> 00:11:58,020
+بتلاقي الأعضاء الأخرين بيهمهم إنه يشوفوا عندهم غير
+
+137
+00:11:58,020 --> 00:12:02,360
+الحطورة
+
+138
+00:12:02,360 --> 00:12:09,720
+نفس الطريقة ولا لأ في حالة إذا كان عائلة عنده
+
+139
+00:12:09,720 --> 00:12:15,240
+chromosomal أو hereditary disorder ويكون المرأة
+
+140
+00:12:15,240 --> 00:12:20,920
+حامل في هذه الوقت بتلاقي بيصير هيكقلق وبيصير
+
+141
+00:12:20,920 --> 00:12:25,800
+anxiety إنه هل هيصير شيء ولا مش هيصير شيء في حالات
+
+142
+00:12:25,800 --> 00:12:29,720
+الـ Pregnancy لشخص
+
+143
+00:12:29,720 --> 00:12:36,460
+أو عائلة عندهم معروف إنه فيه أمراض بروموزومية أو
+
+144
+00:12:36,460 --> 00:12:41,400
+وراثية في حالة الـ Consanguinity يعني هذا الجانب
+
+145
+00:12:41,400 --> 00:12:46,700
+عندنا طبعا يعني في ثقافات أمم أخرىالـ
+
+146
+00:12:46,700 --> 00:12:55,000
+Consanguinity يعني أنا متأكد أو بعرف في مثلًا في
+
+147
+00:12:55,000 --> 00:13:00,540
+ثقافات أخرى مثلًا الروس بنت العم وابن العم هدولة
+
+148
+00:13:00,540 --> 00:13:05,560
+زي الإخوة والأخوات يعني ما بتزوجوا ما بتعرفوا على
+
+149
+00:13:05,560 --> 00:13:11,240
+بعض يعني فعنا الـ Consanguinity في ثقافتنا أكبربس
+
+150
+00:13:11,240 --> 00:13:15,020
+على مستوى بعدي شوية مش first degree أو second
+
+151
+00:13:15,020 --> 00:13:18,720
+degree يعني أو very strong consanguinity موجودة
+
+152
+00:13:18,720 --> 00:13:23,400
+بتلاقي احتمالية تكون موجودة في حالات الـ Teratogen
+
+153
+00:13:23,400 --> 00:13:30,360
+exposure يعني إذا كان إشي معروف إنه بيعمل مشكلة
+
+154
+00:13:30,360 --> 00:13:38,220
+وصار الـ exposure ممكن العائلة تهتم إنها تفهمهل في
+
+155
+00:13:38,220 --> 00:13:45,920
+احتمالية أن يكون شيء Genetic ولا لأ؟ راح ناخد يعني
+
+156
+00:13:45,920 --> 00:13:52,400
+هنا كلمة Teratogen هي مرتبطة بالاشي لما نقول
+
+157
+00:13:52,400 --> 00:13:56,120
+الـCongenital Anomalies الـCongenital يعني خلقي
+
+158
+00:13:56,120 --> 00:14:04,300
+يعني إشي الطفل لما ولد بيبين معاه وكان بيبين معاه
+
+159
+00:14:04,300 --> 00:14:10,150
+فإذا شيء حدث وبالرحم يعنيفمرات مش كل congenital
+
+160
+00:14:10,150 --> 00:14:14,250
+معناته genetic يعني هي لا تساوي هذه congenital
+
+161
+00:14:14,250 --> 00:14:20,990
+يعني في الحمل في خلال فترة الحمل واللي يكون
+
+162
+00:14:20,990 --> 00:14:26,180
+الإنسان جنينويمكن أن يكون كونجينيتال مثلًا «توكسو
+
+163
+00:14:26,180 --> 00:14:32,140
+بلازموسيس» كونجينيتال «روبيلا» مثلًا الحصب
+
+164
+00:14:32,140 --> 00:14:36,300
+الألمانية أو «توكسو بلازموسيس» بيجي من الـ «بيساس»
+
+165
+00:14:36,300 --> 00:14:42,060
+فممكن يعمل التهابات أو مرض في الجنين من خلال إصابة
+
+166
+00:14:42,060 --> 00:14:46,320
+الأم بهذا الشيء فأحيانًا الـ «تيراتوجين» يعني هو
+
+167
+00:14:46,320 --> 00:14:50,610
+بالأخير هيكون شيء خلقييعني سيولد الإنسان فيه، لكن
+
+168
+00:14:50,610 --> 00:14:55,650
+ليس بالضرورة جينيتيكي بس التعامل بينهم قريب كذلك
+
+169
+00:14:55,650 --> 00:14:59,950
+العائلات اللي عندهم repeated pregnancy loss أو
+
+170
+00:14:59,950 --> 00:15:03,470
+infertility هذه برضه من الأشياء اللي بتصير ندور
+
+171
+00:15:03,470 --> 00:15:08,230
+على chromosomal anomalies أو unemployed دي
+
+172
+00:15:08,230 --> 00:15:12,510
+والأشياء اللي زي هيكة فلما نكون في عائلة أو couple
+
+173
+00:15:13,440 --> 00:15:20,060
+زوجين في عندهم مشكلة في عقم وعدم خلفة ممكن أو
+
+174
+00:15:20,060 --> 00:15:23,980
+repeat pregnancy loss طبعاً ممكن يكون أمراض أخرى
+
+175
+00:15:23,980 --> 00:15:30,620
+بس هذه برضه بتكون من الأشياء اللي بيصير عندنا اه
+
+176
+00:15:30,620 --> 00:15:37,000
+يعني اهتمام من الحصول على الاستشارة الوراثية newly
+
+177
+00:15:37,000 --> 00:15:41,030
+diagnosed anomaly or genetic conditionهذه برضه
+
+178
+00:15:41,030 --> 00:15:47,410
+ناحية مهمة عادةً عادةً حتى في عائلة الكل بيخبر بعض
+
+179
+00:15:47,410 --> 00:15:55,430
+فإذا كان إنسان يعني اتشخص بمرض وراثي معين تلقائيًا
+
+180
+00:15:55,430 --> 00:16:00,390
+هتلاقي أفراد العائلة الأخرى إخوانه، خواته، ولاد
+
+181
+00:16:00,390 --> 00:16:06,890
+عمه، مش عارف مين، هيصير كلهم عندهمقلق أو anxiety
+
+182
+00:16:06,890 --> 00:16:12,130
+ويقولوا طب وأنا شو احتماليتي وشو عندي هل أنا كذا
+
+183
+00:16:12,130 --> 00:16:18,330
+فلما يكون تشخيص جديد ومرض جديد هيكون فيه اهتمام في
+
+184
+00:16:18,330 --> 00:16:24,270
+العائلة لطلب استشارة ورافية before undertaking
+
+185
+00:16:24,270 --> 00:16:27,190
+genetic testing and after receiving results
+
+186
+00:16:27,190 --> 00:16:30,870
+particularly in testing for susceptibility of late
+
+187
+00:16:30,870 --> 00:16:40,720
+onset disorders ماشيهذه ناحية مهمة، وهي شغل نادرة،
+
+188
+00:16:40,720 --> 00:16:47,960
+يعني حكينا مثلًا، يعني في على الأقل ثلاث احتمالات،
+
+189
+00:16:47,960 --> 00:16:51,220
+على الأقل أمراض هيكي بتكون عندها الحالة بهذا
+
+190
+00:16:51,220 --> 00:16:56,370
+الطريقةاللي هي مثلًا زي ما حكينا إشي أوتوزامل
+
+191
+00:16:56,370 --> 00:17:00,610
+dominant زي «هانتنغتونز كوريا» أو «Huntington's
+
+192
+00:17:00,610 --> 00:17:05,930
+Disease» بيعمل Paralysis وبيعمل Premature Death بس
+
+193
+00:17:05,930 --> 00:17:10,330
+المرض ما بيبدأ إلا على عمر الأربعين، تلاتين، ستين
+
+194
+00:17:10,330 --> 00:17:16,770
+فتلاقي الإنسان اتزوج وخلف وبعدين فجأة يصاب بمرض
+
+195
+00:17:16,770 --> 00:17:24,870
+بيدي للوفاةفولاده وبناته بيصير عندهم يعني قلق
+
+196
+00:17:24,870 --> 00:17:31,470
+وبدهم يعرفوا شو وضعي أنا فالفكرة أنه أنا ما بيصير
+
+197
+00:17:31,470 --> 00:17:37,590
+أنا أجي أعمل الـ Test و بعدين هكذا و Technician أو
+
+198
+00:17:37,590 --> 00:17:41,130
+إنسان مش خبير ييجي يعطي الإنسان هذا التشخيص
+
+199
+00:17:41,130 --> 00:17:49,160
+وانتهينا، لأ، هذا بدت تقعد الـ Counselorالمستشار
+
+200
+00:17:49,160 --> 00:17:53,840
+يكون فهماً ويقعد مع العيلة قبل ما يعملوا الـ Test
+
+201
+00:17:53,840 --> 00:17:58,000
+يفهمهم ما هو الـ Disease اللي احنا بندور عليه كيف
+
+202
+00:17:58,000 --> 00:18:04,040
+الـ Test راح نعمله؟ وشو الممكن؟ وشو نتيجة تبعت الـ
+
+203
+00:18:04,040 --> 00:18:09,660
+Test؟ كيف نقرأها؟ وبرضه برضه بيظل فيه مشاكل وكذلك
+
+204
+00:18:09,660 --> 00:18:16,910
+مثلا Cancer زي مثلا حكينا اللي هي مثلاحكينا
+
+205
+00:18:16,910 --> 00:18:23,390
+الممثلة العالمية جدولنا عن القردن طلع عندها Braca
+
+206
+00:18:23,390 --> 00:18:28,550
+gene وصوت bilateral mastectomy شارت التديين عندها
+
+207
+00:18:28,550 --> 00:18:33,270
+وكذا عشان عندها strong family history و bilateral
+
+208
+00:18:33,270 --> 00:18:38,810
+cancer في ال breast وبكون عندها hereditary form of
+
+209
+00:18:38,810 --> 00:18:43,470
+cancer أو neurological diseaseهذه ملاحظة مرات
+
+210
+00:18:43,470 --> 00:18:50,370
+كثيرة مثلًا من الأشياء المفهومة مثلًا
+
+211
+00:18:50,370 --> 00:18:56,590
+تشخيص الـ HIV الـ HIV زمان كان زي الحكم بالموت
+
+212
+00:18:56,590 --> 00:19:03,210
+والنبذ والناس تبتعد عن المريض وكذا وكذافكون إن
+
+213
+00:19:03,210 --> 00:19:08,970
+واحد يتعمل HIV، إحنا نعمل HIV لكل واحد مثلا بتبرع
+
+214
+00:19:08,970 --> 00:19:12,750
+بالدم الأصل، مع الـ Hepatitis، مع غيرها، مع غيرها،
+
+215
+00:19:12,750 --> 00:19:16,630
+مع غيرها، مع غيرها، ما بيصير لو طلعت النتيجة
+
+216
+00:19:16,630 --> 00:19:20,630
+إيجابية إنه هيك اتزدها للمريض ذات أو للإنسان هذا
+
+217
+00:19:20,630 --> 00:19:24,010
+ذات طبعا ممكن لو كانت إيجابية إنها تكون False
+
+218
+00:19:24,010 --> 00:19:28,590
+Positive يعني هي مش حقيقية بس والله صارت إنه واحد
+
+219
+00:19:28,590 --> 00:19:33,230
+يسمع النتيجة إنه إيجابييروح ينتحر وخلاص يقولك شوها
+
+220
+00:19:33,230 --> 00:19:38,170
+العيش وشوها الحياة وأنا يعني خلاص I'm going to die
+
+221
+00:19:38,170 --> 00:19:42,390
+مع أن الكلام مش صحيح أبداً فهذه أشياء sensitive
+
+222
+00:19:42,390 --> 00:19:47,850
+والواحد يعمل counseling قبل وبعد ما يعمل ال test
+
+223
+00:19:47,850 --> 00:19:53,810
+لازم ولازم الواحد يعني فهما يستوعب العائلة ويستوعب
+
+224
+00:19:53,810 --> 00:19:57,290
+الإنسان اللي أمامه المريض أو العائلى أو الأبوين
+
+225
+00:19:57,720 --> 00:20:03,980
+ويفهمهم كلام مفهوم ويتفق على آليات معينة فالنقطة
+
+226
+00:20:03,980 --> 00:20:08,060
+الأخيرة حكينا اللي هي as a follow-up for positive
+
+227
+00:20:08,060 --> 00:20:16,860
+result of a newborn test ماشي، يعني هي الفكرة هنا
+
+228
+00:20:16,860 --> 00:20:22,600
+حاطين أنواع من الأشياء ال test اللي بتنعمل، النقاط
+
+229
+00:20:22,600 --> 00:20:34,410
+هناعندنا مثلًا في القردن كل الأطفال عند أول تطعيم
+
+230
+00:20:34,410 --> 00:20:39,710
+بعد أسبوع أو خلال الفترة الأولى من نقطة من القدم
+
+231
+00:20:39,710 --> 00:20:50,190
+على ورقة نشاف بنشفوا نقطة الدم وبعدها تُبعث للفحص
+
+232
+00:20:50,980 --> 00:20:55,920
+الـ Phenylketonuria والـ Thyroid وحتى الـ HIV أظن
+
+233
+00:20:55,920 --> 00:21:02,060
+بيعملوه روتين للكل ماشي، فإيه ده؟ طبعاً كل هذه
+
+234
+00:21:02,060 --> 00:21:07,500
+الفحوصات مش 100% الـ Sensitivity و Specificity
+
+235
+00:21:07,500 --> 00:21:11,620
+تبعتها يعني لو Positive ممكن تكون False Positive
+
+236
+00:21:11,620 --> 00:21:14,820
+لو Negative ممكن كمان تكون False Negative يعني حتى
+
+237
+00:21:14,820 --> 00:21:20,160
+لو فحص ممتاز 99% بيجيبها صح مافي إشي 100% في
+
+238
+00:21:20,160 --> 00:21:27,540
+الدنيا يعنيففي أمراض معينة لو أجت لسبب طلع نتيجة
+
+239
+00:21:27,540 --> 00:21:34,140
+إيجابي أو plus minus يعني على الحفة فكيف بدنا نفهم
+
+240
+00:21:34,140 --> 00:21:39,940
+العائلة هذا الموضوع هي بدها أنه يصير genetic
+
+241
+00:21:39,940 --> 00:21:43,960
+counseling الـ
+
+242
+00:21:44,840 --> 00:21:48,580
+أنا بحكي، أنا بتكلم، إذا حد عنده سؤال، يسأل إذا
+
+243
+00:21:48,580 --> 00:21:54,880
+فيه إيش مش واضح، شو اسمه، احكولي وخلّينا بنوقف
+
+244
+00:21:54,880 --> 00:21:59,680
+وبنعيد، يعني، ماشي الحال؟ فدولة الـ Indications
+
+245
+00:21:59,680 --> 00:22:04,140
+for Genetic Counseling دولة العادة الحوادث أو
+
+246
+00:22:04,140 --> 00:22:10,880
+القصص أو الأشياء اللي تدفع بعض العائلات ليطلبوا
+
+247
+00:22:10,880 --> 00:22:12,520
+الـ Genetic Counseling
+
+248
+00:22:15,080 --> 00:22:19,900
+لما يأتي الإنسان اللي هو الـ Counselor، ما هو
+
+249
+00:22:19,900 --> 00:22:24,920
+المفروض أن يفعله؟ النقطة الأولى، يجب أن يقوم
+
+250
+00:22:24,920 --> 00:22:27,940
+بـCollection of Information اللي هي الـ Family
+
+251
+00:22:27,940 --> 00:22:31,880
+History، الـ Medical History والـ Previous Tests
+
+252
+00:22:31,880 --> 00:22:35,440
+وAdditional Assessments يعني كل هذه الجوانب، يجب
+
+253
+00:22:35,440 --> 00:22:41,920
+أن يجمعها ويرتبها مع بعض الـ Family History يمكن
+
+254
+00:22:41,920 --> 00:22:47,320
+من أهم شيءأيه قضية اللي هي الـ Pedigree؟ ماشي،
+
+255
+00:22:47,320 --> 00:22:55,160
+فمين في العائلة مصاب، على أي عمر بدأت، شو علاقاتهم
+
+256
+00:22:55,160 --> 00:22:59,500
+ببعض، متأكد الواحد من المعلومة، مش متأكد، يجمع
+
+257
+00:22:59,500 --> 00:23:02,220
+المعلومات كلها، فأول شيه Collection of
+
+258
+00:23:02,220 --> 00:23:06,640
+Information، هذه نقطة أساسية، بعدين لازم يفحص
+
+259
+00:23:06,640 --> 00:23:12,610
+المريض، ويشوف كل نتاجه، Physical Examination،عنده
+
+260
+00:23:12,610 --> 00:23:18,550
+ما عندهوش مثلًا يعني والله أنا شُفت مثلًا إنسان
+
+261
+00:23:18,550 --> 00:23:25,130
+طويل وعنده high arch بلد وعنده أنا فكرت أنه عنده
+
+262
+00:23:25,130 --> 00:23:29,250
+إيش بنسميه «marfan syndrome» ولا كذا وإيكي هذا
+
+263
+00:23:29,250 --> 00:23:33,270
+مرتبط مثلًا بـcongenital heart disease فيمكن
+
+264
+00:23:33,270 --> 00:23:37,450
+المريض عنده «مرمر» وعنده مشكلة في القلب ومريض فعلا
+
+265
+00:23:37,450 --> 00:23:41,280
+وعنده «congenital»بس ماكانش حدا لأنه ماشتكاش،
+
+266
+00:23:41,280 --> 00:23:45,600
+ماحدش فحصه فمش عارفين عن وجود أو عدم وجود جانب
+
+267
+00:23:45,600 --> 00:23:50,980
+معين بعدين الـ Physical Examination الـ Laboratory
+
+268
+00:23:50,980 --> 00:23:54,180
+of Radiological Testing وValidation or
+
+269
+00:23:54,180 --> 00:23:59,420
+Establishment of Diagnosis if possible، ماشي؟ يعني
+
+270
+00:23:59,420 --> 00:24:04,340
+بيجمع الواحد كمان كل النتائج بما فيها الأشعات
+
+271
+00:24:04,340 --> 00:24:11,060
+السابقة والنتائج تبعتهاوالـ Validation أو الـ
+
+272
+00:24:11,060 --> 00:24:14,280
+Establishment بالذات فيه فرصات أدق على هذا الموضوع
+
+273
+00:24:14,280 --> 00:24:23,820
+يعني إنسان عنده مثلًا والله ضمور في العضلات وخلل
+
+274
+00:24:23,820 --> 00:24:31,060
+في العضلات لو كان الشغل هذه من الصغر ومن الطفولة
+
+275
+00:24:31,600 --> 00:24:36,040
+بتكون مرض معين، بس لو نفس المشكلة أو إشي شبيه فيها
+
+276
+00:24:36,040 --> 00:24:40,320
+على عمر أكبر، لأ، بتصير بكر disease بدل Duchenne
+
+277
+00:24:40,320 --> 00:24:46,200
+muscular dystrophy فبتصير يعني التشخيص على أي عمر
+
+278
+00:24:46,200 --> 00:24:50,540
+كانت، فحتى نتأكد أن المشكلة ما بدت بعمر أسبق،
+
+279
+00:24:50,540 --> 00:24:54,720
+فنشوف النتاج القديمة ونجمعها الـ Counseling
+
+280
+00:24:58,040 --> 00:25:02,040
+تتكلم الواحد على الـ Nature وConsequences of the
+
+281
+00:25:02,040 --> 00:25:10,160
+Disorder يعني، ماذا يريد أن يشرح للذي أمامه؟ ما هو
+
+282
+00:25:10,160 --> 00:25:16,680
+المرض؟ وما هو طبيعته؟ وما هو نتاجه؟ بما فيها أرقام
+
+283
+00:25:16,680 --> 00:25:22,120
+واحتمالات وكذلك الـ Recurrence Risk Availability
+
+284
+00:25:22,120 --> 00:25:28,540
+of Further or Future Testingيعني مثلًا الـ Down
+
+285
+00:25:28,540 --> 00:25:32,400
+Syndrome الـ Down Syndrome ماشي هو هذا الإنسان
+
+286
+00:25:32,400 --> 00:25:36,520
+عنده Down Syndrome بس في نفس الوقت ممكن الـ Down
+
+287
+00:25:36,520 --> 00:25:42,380
+Syndrome يكون مزايق يعني الـ Trisomy 21 مش في كل
+
+288
+00:25:42,380 --> 00:25:46,280
+الـ Cells في نص الـ Cells، في تلت أرباع الـ Cells،
+
+289
+00:25:46,280 --> 00:25:50,420
+في عشرين بالمئة بالـ Cells فبتصير درجات من هذه
+
+290
+00:25:50,420 --> 00:25:57,050
+الحالة، بالتالي بكونيعني توقعنا بالنسبة لشو نعمل
+
+291
+00:25:57,050 --> 00:26:03,230
+أو شو درجتنا، شو يعني توقعنا عن المستقبل راح يكون
+
+292
+00:26:03,230 --> 00:26:08,470
+قراءتنا للمستقبل بتكون تختلف، بعدين الـ decision
+
+293
+00:26:08,470 --> 00:26:13,070
+making شو القرارات اللي ممكن تتنفق عليها referral
+
+294
+00:26:13,070 --> 00:26:16,470
+to other specialists أو health agencies أو support
+
+295
+00:26:16,470 --> 00:26:23,660
+groups يعني مثلا أنا واللهالقيت حالي عنده final
+
+296
+00:26:23,660 --> 00:26:30,620
+cataneuria إذا يمكن الأهل والناس أولها بيصدموا «شو
+
+297
+00:26:30,620 --> 00:26:35,240
+هالشغل؟» بخاف الواحد وكذا بعدين بحكيله «والله هاي
+
+298
+00:26:35,240 --> 00:26:38,960
+لا، والله الشغل شائعة» «في عنا جمعية بتقوم
+
+299
+00:26:38,960 --> 00:26:44,340
+بالرعاية هذه الحالات» إذا اتعامل الواحد مظبوط مع
+
+300
+00:26:44,340 --> 00:26:49,380
+المرض من الصغر وابتشف مبكر والعلاج والأكل مظبوط
+
+301
+00:26:49,670 --> 00:26:53,110
+الطفل اللي بيعيش أو الإنسان هذا بيطلع طبيعي ومافيش
+
+302
+00:26:53,110 --> 00:26:57,590
+معاه مشكلة فبوديه على الـ Support Groups فيه
+
+303
+00:26:57,590 --> 00:27:03,090
+عيادات معينة إنهم فيه جمعيات متخصصة بتعتني فيهم
+
+304
+00:27:03,090 --> 00:27:08,970
+فيه كذا فيه كذا فكله بتصير الواحد يعطيهم يعني
+
+305
+00:27:08,970 --> 00:27:13,600
+يقودهم في أنه يتعاملوا مع المرض هذاcontinuing
+
+306
+00:27:13,600 --> 00:27:16,440
+clinical assessment especially if no diagnosis
+
+307
+00:27:16,440 --> 00:27:20,480
+وطبعاً الـ Psychosocial support هذه نواحي مهمة
+
+308
+00:27:20,480 --> 00:27:24,000
+كثير إن الواحد يظل يتابع إذا واحد ما يعرفش إيش
+
+309
+00:27:24,000 --> 00:27:29,440
+يقول، مايعرفش، مش متأكد ما يفتي بثقة، يحكي بثقة
+
+310
+00:27:29,440 --> 00:27:39,720
+للي أمامه، هو يعني مش متأكد، بس في المقابل يعني من
+
+311
+00:27:39,720 --> 00:27:44,050
+أهم الجوانب، يعني بقدر حواليثلاثين بالمية من تأثير
+
+312
+00:27:44,050 --> 00:27:50,630
+الطب هو تأثير نفسي يعني اللي بيسموه الـ placebo
+
+313
+00:27:50,630 --> 00:27:55,630
+effect يعني كثير من مثلا بيكون بطن الواحد بوجعه
+
+314
+00:27:55,630 --> 00:28:00,130
+وفي لحظة ما بيبدأ يدخل على المستشفى يكون بيصرخ و
+
+315
+00:28:00,130 --> 00:28:05,190
+بعيط و كده بس لسه بده يدخل على باب الطوارئ بيدلاق
+
+316
+00:28:05,190 --> 00:28:11,170
+الألم خارج وهذه ظاهرة لكل بعرفها وهذه يعنيدور من
+
+317
+00:28:11,170 --> 00:28:18,470
+أدوار الـ Counselor إنه يؤديها الـ
+
+318
+00:28:18,470 --> 00:28:24,810
+«دكتور»؟ نعم في سؤال الماضي بتسأل إنه مش كل
+
+319
+00:28:24,810 --> 00:28:29,190
+الـGenetic Disease بيكونوا Congenital؟ لأ، ما هو،
+
+320
+00:28:29,190 --> 00:28:33,630
+شوفي أنا اتكلمت عن الموضوع هذا يعني زي
+
+321
+00:28:33,630 --> 00:28:38,820
+Huntington's Chorea أو Huntington's Diseaseهذا مرض
+
+322
+00:28:38,820 --> 00:28:46,060
+في الأعصاب، الإنسان بولد طبيعي، بعيش طبيعي، بخلف،
+
+323
+00:28:46,060 --> 00:28:51,740
+بكون عائلة على سن الأربعين، خمسين، ستين، بظهر عنده
+
+324
+00:28:51,740 --> 00:28:59,180
+المرض وهو Autosomal Dominant فكلمة Congenital تعني
+
+325
+00:28:59,180 --> 00:29:04,700
+«ظهرت عند الولادة» يعني لما نولد الإنسان، هاي
+
+326
+00:29:04,700 --> 00:29:09,710
+الشغر مبين عندهفكلمة «congenital» يعني حكينا
+
+327
+00:29:09,710 --> 00:29:15,430
+«congenital toxoplasmosis» «congenital rubella»
+
+328
+00:29:15,430 --> 00:29:20,010
+هدولة يعني هن «congenital» بس هدولة «infectious
+
+329
+00:29:20,010 --> 00:29:24,050
+disease» مش «genetic» فكلمة «genetic» و
+
+330
+00:29:24,050 --> 00:29:28,390
+«congenital» لا تعني نفس الكلمة ماشي، يعني في
+
+331
+00:29:28,390 --> 00:29:31,630
+أمراض «genetic» مش «congenital» لإن نقدرش نعتبرها
+
+332
+00:29:31,630 --> 00:29:35,530
+«congenital» بس أحياناً يعني «hereditary» و
+
+333
+00:29:35,530 --> 00:29:41,740
+«congenital»بتُعطى كأنه مصطلحات قريبان من بعض
+
+334
+00:29:41,740 --> 00:29:46,320
+وكأنها نفس المعنى يعني بقصد الواحد إشي ورافي يعني،
+
+335
+00:29:46,320 --> 00:29:52,100
+ماشي؟ فالورافي مش ضروري تظهر عند الولادة، واضح؟
+
+336
+00:29:52,100 --> 00:29:56,020
+فلما الواحد يستخدم مصطلح، بده، بالذات إذا فيه
+
+337
+00:29:56,020 --> 00:30:02,080
+فروقات بينهم، بده ينتبهلها، ماشي؟ يعني Congenital
+
+338
+00:30:02,080 --> 00:30:08,540
+Heart Disease، ماشي؟بكون خلل معين هو خلقي وحتى لو
+
+339
+00:30:08,540 --> 00:30:12,540
+ما اكتشفتوش بالأول بس لو كنت أنا فحست عليه عند
+
+340
+00:30:12,540 --> 00:30:16,180
+الولادي يعني مثلا في congenital heart disease الـ
+
+341
+00:30:16,180 --> 00:30:23,080
+«Communist» بيسموه «Bicusp aortic valve» الصمام
+
+342
+00:30:23,080 --> 00:30:27,320
+الأبهر الـ«اوارتك» المفروض له ثلاث شفائف، له ثلاث
+
+343
+00:30:27,320 --> 00:30:34,300
+قطع بالنسبة للناس، بتكون من قطعتين فقطهذا ممكن إذا
+
+344
+00:30:34,300 --> 00:30:39,940
+ما حدش فحص عليه بدقة أو دور عليه يبين بعدين على سن
+
+345
+00:30:39,940 --> 00:30:44,660
+العشرين، تلاتين، أربعين بيبين أوورتكستناصس بيبين
+
+346
+00:30:44,660 --> 00:30:49,580
+عند الإنسان بيخلي عنده يظهر مشكلة تتطور وبتبين
+
+347
+00:30:49,580 --> 00:30:54,790
+بعدين فهي تلغى هذه النوع من المشكلةصحيح إننا
+
+348
+00:30:54,790 --> 00:31:00,670
+اكتشفناها متأخر بس هي خلقية يعني congenital يعني
+
+349
+00:31:00,670 --> 00:31:09,330
+من ولادته بدأت فيه، ماشي؟ بس مش كل congenital
+
+350
+00:31:09,330 --> 00:31:15,150
+بالضرورة genetic، خلّينا نكون واضحين، ماشي؟ فاحنا
+
+351
+00:31:15,150 --> 00:31:20,530
+أحيانًا كثيرة نستخدم المصطلحين بشكل متبادل بس هم
+
+352
+00:31:20,530 --> 00:31:22,770
+لأ مش نفس المعنى
+
+353
+00:31:27,150 --> 00:31:34,130
+واضح؟ ‏- لا تمام يا دكتور ‏- أه الـ Genetic
+
+354
+00:31:34,130 --> 00:31:40,070
+Counseling ‏and Risk Assessment ‏يعني الـ أحنا
+
+355
+00:31:40,070 --> 00:31:44,970
+المطلوب هنا أول شيء أن نفهم العائلة الـ Medical
+
+356
+00:31:44,970 --> 00:31:52,790
+Facts ‏يعني ضروري الـإذا العائل يمكن أنه صعب أن
+
+357
+00:31:52,790 --> 00:31:56,750
+يدرس الواحد طب ويدرس قليل من الـ Genetics وكذا
+
+358
+00:31:56,750 --> 00:32:01,610
+فالدور
+
+359
+00:32:01,610 --> 00:32:07,810
+الأول المطلوب أنه نتأكد إنهم فاهمين النواحي
+
+360
+00:32:07,810 --> 00:32:17,310
+العلمية الطبية السليمة الأساسية عن التشخيص وندرسهم
+
+361
+00:32:17,310 --> 00:32:23,810
+علىكيف تنتقل؟ وليش تنتقل؟ وما هي الخطورة أو
+
+362
+00:32:23,810 --> 00:32:28,930
+احتمالية عودة المشكلة معاهم أو في أعضاء العائل
+
+363
+00:32:28,930 --> 00:32:35,610
+الآخرين؟ أعطاهم خيارات
+
+364
+00:32:35,610 --> 00:32:39,590
+ما يعملونه للمستقبل وكيف يتعاملوا مع الحالة يعني
+
+365
+00:32:39,590 --> 00:32:44,970
+أنا كثير مع الدكتورة، الله يرضى عنها الدكتورة
+
+366
+00:32:45,560 --> 00:32:50,640
+الوراثة في الأطفال، التناسق في الحيط نقعد مثلًا مع
+
+367
+00:32:50,640 --> 00:32:58,940
+عيلة عندهم مثلًا فيناكوتينيوريا ونسير يعني يكون
+
+368
+00:32:58,940 --> 00:33:02,620
+مثلًا الأب والأم يتلوموا أنت المرض منك، أنت المرض
+
+369
+00:33:02,620 --> 00:33:08,220
+منك، لأ المرض أنتم اتنين مشتركين فيه مثلًا يعني
+
+370
+00:33:08,220 --> 00:33:12,560
+هذه ناحية بدّوا الواحد ينتبهي لها فمثلًا هذه
+
+371
+00:33:12,560 --> 00:33:17,440
+العائلات بعضهمكنا ننصحهم مثلًا، خلاص، ما تخلفوش
+
+372
+00:33:17,440 --> 00:33:24,440
+طبعًا في دول تانية ممكن يكون مثلًا الإجهاض خيار بس
+
+373
+00:33:24,440 --> 00:33:28,060
+إحنا مثلًا عندنا نقول لهم لأ ما تخلفوش كمان ولاد
+
+374
+00:33:28,060 --> 00:33:33,200
+عشان لأنه لسه فيه نسبة ونعتبرها نسبة عالية لأنه
+
+375
+00:33:33,200 --> 00:33:41,560
+معاناة شديدة أنه يكون هناك مرض يعني بالنسبة لما
+
+376
+00:33:41,560 --> 00:33:46,560
+نتعامل بهذه النقاطمعرفة الـ Values، Beliefs،
+
+377
+00:33:46,560 --> 00:33:52,520
+Goals، Relationships نتيجة الـ Presence of
+
+378
+00:33:52,520 --> 00:33:57,700
+Hereditary Diseases يعني بد الواحد يراعي في هذا
+
+379
+00:33:57,700 --> 00:34:09,080
+الموضوع بدنا نسميه ثقافة، الدين، أخلاقيات، مفاهيم
+
+380
+00:34:09,080 --> 00:34:16,190
+الإنسان اللي أمامه يعني إحناأقول دايماً للدكاترة
+
+381
+00:34:16,190 --> 00:34:21,890
+وللطباء إحنا لما واحد يصير طبيب بقسم يعني بحلف
+
+382
+00:34:21,890 --> 00:34:29,210
+بالله أنه راح نعالج القريب والعدو الصالح والخاطر
+
+383
+00:34:29,210 --> 00:34:37,550
+القريب والبعيد يعني أنا كإنسان طبيب لمن يلجألي شخص
+
+384
+00:34:37,550 --> 00:34:43,290
+لأنه طبيبفي أخلاقيات أنا مسؤول عنها ومنها إنه
+
+385
+00:34:43,290 --> 00:34:47,950
+أحترم هذا الإنسان أحترم خصوصيته أحترم سرية
+
+386
+00:34:47,950 --> 00:34:54,510
+معلوماته أحترم مفاهيمه فهذا الاحترام يكون بنتج عنه
+
+387
+00:34:54,510 --> 00:35:01,290
+إن أنا لازم أحترم طبعاً يعني النواحي الفردية هذه
+
+388
+00:35:01,290 --> 00:35:06,510
+التابعته بغض النظر عن إن أنا قابلها ولا مش قابلها
+
+389
+00:35:06,510 --> 00:35:11,120
+عجباني مش عاجبانيبسوي على حالي و لا لأ خلاص لازم
+
+390
+00:35:11,120 --> 00:35:16,400
+احترم مين ما يكون أمامي ماشي و في نفس الوقت يعني
+
+391
+00:35:16,400 --> 00:35:23,500
+أنا بظن جانب مهمة احنا لازم يعني في الجوانب هذه
+
+392
+00:35:23,500 --> 00:35:30,860
+الجوانب المجتمعية بما فيها من قوانين من أعراف تحكم
+
+393
+00:35:30,860 --> 00:35:36,780
+التعامل مع هذه الجانبوبالتالي، يعني أنا لازم أسهل
+
+394
+00:35:36,780 --> 00:35:41,660
+و أشرح لهم يعني يمكن عائلة بتفضل إشي معين بس
+
+395
+00:35:41,660 --> 00:35:46,840
+القانون يمنعه مثلا، بدي أوفق بينها و بدي أشرح
+
+396
+00:35:46,840 --> 00:35:52,180
+للجميع و نشرح شو نعمله و كيف نعمله و بعدين،
+
+397
+00:35:52,180 --> 00:35:58,200
+الاختيار ال course of action ماشي، نساعدهم كيف، شو
+
+398
+00:35:58,200 --> 00:36:04,870
+اللي يعملوا، راح نيجي بعد شويةعلى قضية الـ…. يعني
+
+399
+00:36:04,870 --> 00:36:11,090
+الـ…. إذا كان في طريق التشخيص أمراض وراثية بشكل
+
+400
+00:36:11,090 --> 00:36:16,370
+تداخلي، بشكل invasive لنأخذ عينة ولا نعمل شغل ولا
+
+401
+00:36:16,370 --> 00:36:23,210
+كذا، وبعدين إذا كان يعني بما أن الواحد هنا اللي
+
+402
+00:36:23,210 --> 00:36:27,610
+بيعمل counseling هو أخبر واحد في بالنسبة لتعامل مع
+
+403
+00:36:27,610 --> 00:36:33,540
+المرض، تخفيف أثاره،تعامل مع تعليف الإنسان هذا أو
+
+404
+00:36:33,540 --> 00:36:39,120
+العائلة بالمشاكل أو ما هي الخيارات اللي أمامهم،
+
+405
+00:36:39,120 --> 00:36:44,780
+فدول كلها جوانب مهمة من
+
+406
+00:36:44,780 --> 00:36:52,940
+النواحي المهمة، وهنا حاطين مثال عليها، قضية أن الـ
+
+407
+00:36:52,940 --> 00:36:59,540
+Counselor لازم يعطي العائلةالأصل، يعني وذلك بالذات
+
+408
+00:36:59,540 --> 00:37:04,720
+عائلة فهمانة ويمكن هذا في الدول الغربية ثقافتهم في
+
+409
+00:37:04,720 --> 00:37:09,660
+هذا الجوانب أحسن مننا بالنسبة لقضية أنه بدك رقم
+
+410
+00:37:09,660 --> 00:37:11,620
+وعلى أساس أنك أنت إنسان علمي
+
+411
+00:37:14,200 --> 00:37:22,100
+بالنسبة للـ «Risk Assessment» ماشي، اللي هي شو
+
+412
+00:37:22,100 --> 00:37:25,740
+إحتمالية إنه هذا الإنسان عنده كده، شو إحتمالية
+
+413
+00:37:25,740 --> 00:37:30,840
+كده، فهي قضية الإحصاء والاحتماليات، هنا جانب يجب
+
+414
+00:37:30,840 --> 00:37:36,700
+أن يكون شاطر فيه، فلما نرسم الـB degree، لازم
+
+415
+00:37:36,700 --> 00:37:44,310
+بالأخير كمان نحصل الشيء اسمه،منها معلومات رقمية
+
+416
+00:37:44,310 --> 00:37:51,550
+ممكن نعطيها للعائلة حتى نساعدهم فهنا مثلًا هذا مرض
+
+417
+00:37:51,550 --> 00:37:56,330
+Autism Recessive مثلًا Penile Continuity الآن
+
+418
+00:37:56,330 --> 00:38:05,290
+الإنسان هذا اللي هو الأزرق المصاب عنده Two copies
+
+419
+00:38:05,290 --> 00:38:08,830
+لأنه Autism Recessive فعنده Two copies of the
+
+420
+00:38:08,830 --> 00:38:15,920
+affected gene ماشيالآن الأب والأم، هذه الأم وهذا
+
+421
+00:38:15,920 --> 00:38:24,540
+الأب لازم يكون Carrier فاحتمالية إنه عنده Copy من
+
+422
+00:38:24,540 --> 00:38:34,780
+الـ…. ما هو اسمه؟عنده يكون copy من الـ «أفكتت جين»
+
+423
+00:38:34,780 --> 00:38:39,000
+is one percent يعني one hundred percent، ماشي؟
+
+424
+00:38:39,000 --> 00:38:44,180
+ماعندهوش أكيد two copies لأنه مش مصاب، لو كان الأب
+
+425
+00:38:44,180 --> 00:38:49,760
+أو الأم مصابين زي الإبن، ماشي؟ يمكن ماكانوش خلفوا
+
+426
+00:38:49,760 --> 00:38:54,740
+أو ماكانوش اتجوز و لا كده، بس هي تعني أنه احتمالية
+
+427
+00:38:54,740 --> 00:38:58,390
+أن يكون الإنسان عندهالـ One copy of the affected
+
+428
+00:38:58,390 --> 00:39:08,010
+gene هنا 1% العائلة البقيتها يعني هنا الاحتمالية
+
+429
+00:39:08,010 --> 00:39:14,870
+100% وبالتالي بناخد أنه نص بنص كان للجدود بالنسبة
+
+430
+00:39:14,870 --> 00:39:22,700
+لهذا الإنسانوالأمر بينطبق على الطرفين، ماشي؟ لو
+
+431
+00:39:22,700 --> 00:39:31,420
+هنا مثلًا بالنسبة للإنسان هذا النسبة
+
+432
+00:39:31,420 --> 00:39:39,800
+إنه يكون مثلًا هنا بنت عمه، ماشي؟ هي هنا، لأ، هي
+
+433
+00:39:39,800 --> 00:39:48,540
+تطلع هنا الزلمي هذا اتزوج أول مرةجاب يعني اتزوج من
+
+434
+00:39:48,540 --> 00:39:54,980
+امرأة ثانية معينة وجاب طفل مصاب اتزوج مرة ثانية
+
+435
+00:39:54,980 --> 00:40:01,060
+بزوجة ثانية كان عندها، هاي لأ، هاي أخته أنا آسف،
+
+436
+00:40:01,060 --> 00:40:10,360
+هاي أخته فأخته بما أنه الاحتمالي،
+
+437
+00:40:10,360 --> 00:40:13,200
+يعني هذا إنسان حامل لـone copy of the gene
+
+438
+00:40:13,200 --> 00:40:20,460
+definite أنا متأكدماشي، أخذوا نص من الاحتمال من
+
+439
+00:40:20,460 --> 00:40:27,740
+الجد نص من الجد من هذا الجانب فواحد منهم عنده
+
+440
+00:40:27,740 --> 00:40:33,900
+الـGene والاحتمالية نص لكل واحد منهم الأخت تبعت
+
+441
+00:40:33,900 --> 00:40:38,200
+الأب في الحالة هذه الاحتمالية إنه يكون عندها
+
+442
+00:40:38,200 --> 00:40:44,920
+الإصابة أو حامل الـGene الموروض هي نصالاحتمالية
+
+443
+00:40:44,920 --> 00:40:52,200
+يعني الـ Probability 50% لما تتزوج من شخص طبيعي من
+
+444
+00:40:52,200 --> 00:40:57,160
+الـ General population ماشي وعلى اختراد أن هذا
+
+445
+00:40:57,160 --> 00:41:01,560
+المرض أو الحالة هذه نادرة واحتمالية ما تكون موجودة
+
+446
+00:41:01,560 --> 00:41:10,040
+قليلة جداً فبنتج أنه راح تعطي هي لابنها أو بنتها
+
+447
+00:41:10,040 --> 00:41:15,600
+هنا اللي بتصير الاحتمالية الربعماشي، فهذه الـ
+
+448
+00:41:15,600 --> 00:41:22,480
+Probability، ماشي الـ Probability of being a
+
+449
+00:41:22,480 --> 00:41:26,900
+career يعني career عندك نسخة واحدة فهنا حاطين
+
+450
+00:41:26,900 --> 00:41:32,160
+النسب لمجموعة أفراد العائلة الأب والأم لازم يكونوا
+
+451
+00:41:32,160 --> 00:41:39,560
+حاملين الـ Other first degree relatives النُص لكل
+
+452
+00:41:39,560 --> 00:41:44,420
+واحد منهمالـ Second degree relative بتصير الرُبع
+
+453
+00:41:44,420 --> 00:41:54,820
+زي هنا، ماشي؟ سبب النقطة هذه سبب النقطة هذه أنه
+
+454
+00:41:54,820 --> 00:41:57,920
+الـ
+
+455
+00:41:57,920 --> 00:42:03,820
+يعني النقطة اللي بحكيها بهذه الطريقة أنه إحنا بثقة
+
+456
+00:42:03,820 --> 00:42:10,820
+بنحط النسب هذه لسببين، السبب الأول أنهالعلاقات
+
+457
+00:42:10,820 --> 00:42:15,200
+واضحة والسبب الثاني أنه المرض واضح واحنا عارفينه
+
+458
+00:42:15,200 --> 00:42:19,680
+وعارفين الـGene تبعه نقدر نروح نفحص عليه لما نكون
+
+459
+00:42:19,680 --> 00:42:24,140
+احنا عارفين وواثقين نعطي أرقام زي هيك ونكون
+
+460
+00:42:24,140 --> 00:42:30,180
+متأكدين من الموضوع لما نكون في حالة لأ مش Autism
+
+461
+00:42:30,180 --> 00:42:36,960
+or Recessiveماشي، أنه كشخص،
+
+462
+00:42:36,960 --> 00:42:44,360
+احنا، ماشي، عندنا إنسان مصاب، بس أنا، يعني مش زي
+
+463
+00:42:44,360 --> 00:42:48,060
+الـ Autosomal Recessive Mendelian Inheritance، One
+
+464
+00:42:48,060 --> 00:42:54,880
+Position، وخلاص، انتهيت، لأهنا بدي أستخدم الإحصاء
+
+465
+00:42:54,880 --> 00:43:00,240
+وأستخدم الاحتمالات بحيث أني أقدر أصل من خلال
+
+466
+00:43:00,240 --> 00:43:04,340
+معلومات يعني المجتمع ككل، نسبة حدوث المرض، نسبة
+
+467
+00:43:04,340 --> 00:43:08,920
+حدوثه، نتيجة كذا، نتيجة كذا، وكلنا نحط بعض الأرقام
+
+468
+00:43:08,920 --> 00:43:16,280
+على احتمالياتها، لما نيجي مثلا عائلة، أثنين شكلهم
+
+469
+00:43:16,280 --> 00:43:22,000
+مظهريا طبيعيين، عندهم حالة مصابة،من كلهم، طيب،
+
+470
+00:43:22,000 --> 00:43:26,440
+الطفل الثاني شو احتمالية إنه يكون مصاب بنفس
+
+471
+00:43:26,440 --> 00:43:31,240
+الطريقة؟ ها بدنا ناخد بعض الأمثلة ولا كده؟ فهنا
+
+472
+00:43:31,240 --> 00:43:37,460
+يعني اللي بيحطونيا هم الصراحة، يعني الجميل في
+
+473
+00:43:37,460 --> 00:43:41,820
+الكتاب والمرجع هذا إن الصورة بيكتبلك إذا الواحد
+
+474
+00:43:41,820 --> 00:43:47,020
+بنتبه عليها شريح كامل راح يلاقي فيها معلومات مفيدة
+
+475
+00:43:47,020 --> 00:43:55,420
+بشكل كبيرفيعني هنا كدراسة بقولّك
+
+476
+00:43:55,420 --> 00:44:04,020
+إذا Down Syndrome ماشي وطبعاً إله دخل بالـ…
+
+477
+00:44:04,020 --> 00:44:08,760
+يعني هو الـTrisomy 21 إله ممكن Non-disjunction
+
+478
+00:44:08,760 --> 00:44:14,160
+وTrisomy 21 وبشكل عادي إله دخل بالـMaternal Age
+
+479
+00:44:15,340 --> 00:44:20,040
+النسبة احتمالية إن الطفل الثاني يكون مصاب بنفس
+
+480
+00:44:20,040 --> 00:44:26,520
+الطريقة 1% عامًا بس إذا كان لقى الواحد روبرتسيان
+
+481
+00:44:26,520 --> 00:44:31,180
+Translocation النسبة أعلى بكتير يمكن 30 مرة أو 20
+
+482
+00:44:31,180 --> 00:44:35,620
+مرة أعلى إنه يكون الطفل الثاني كمان وايد حكينا
+
+483
+00:44:35,620 --> 00:44:43,090
+مثال على ذلك يعني الواحد لما نيجيبـ degree مثل هذا
+
+484
+00:44:43,090 --> 00:44:48,450
+وهو الإنسان المصاب وأخونا المصاب اللي اكتشفنا منه
+
+485
+00:44:48,450 --> 00:44:52,530
+المرض والعائلة جاي تسأل شو الوضع بالنسبة للقادم
+
+486
+00:44:52,530 --> 00:44:56,650
+بدي يكون الواحد يجمع معلومات قدر ما بيقدر ويكون
+
+487
+00:44:56,650 --> 00:45:01,610
+فاهم شو ال inheritance وعنده معلومات عليه الآن
+
+488
+00:45:01,610 --> 00:45:14,600
+المثال اللي حكيناه اللي هو نقطةإنه المثال
+
+489
+00:45:14,600 --> 00:45:18,280
+اللي قبل شويه الـ Autism and Recessive إذا أخدنا
+
+490
+00:45:18,280 --> 00:45:23,280
+Autism and Recessive كـ Disease، ماشي؟ لما نكون
+
+491
+00:45:23,280 --> 00:45:32,160
+عندي شخص مصاب، فأقول إن الأب والأم لازم يكونوا
+
+492
+00:45:32,160 --> 00:45:37,820
+حاملين، Obligate Carriersيعني هم بالتأكيد حاملين
+
+493
+00:45:37,820 --> 00:45:46,760
+عشان يجيبوا طفل مصعب الفكرة في الـA إنه نتيجة إن
+
+494
+00:45:46,760 --> 00:45:52,080
+هنا نص بنص الـ«one gene» «one copy affected»
+
+495
+00:45:52,080 --> 00:45:57,740
+وبالتالي لما يكون احتمالية عشان يظهر autosomal
+
+496
+00:45:57,740 --> 00:46:01,060
+recessive لازم يكون homozygous لازم يكون «too
+
+497
+00:46:01,060 --> 00:46:06,340
+affected» تصير احتمالية ربعبس الفكرة إن الربع هذه
+
+498
+00:46:06,340 --> 00:46:12,200
+أكيدة كيف يعني أكيدة؟ القصد فيها إن كاحتمالية إنها
+
+499
+00:46:12,200 --> 00:46:23,420
+ربع أكيد فأجى طفل مصاب و بعدين، شو اسمه؟ مثلا، هاي
+
+500
+00:46:23,420 --> 00:46:28,320
+عيلة ثانية بالـB بعد هيك جابوا ستة ذكور وإناس
+
+501
+00:46:28,320 --> 00:46:32,280
+فحاطينهم بشكل هذا جابوا ستة وكلهم طبيعيين
+
+502
+00:46:34,700 --> 00:46:39,880
+الآن صاروا سبعة عند العيالة هذه «شو إحتمالية الولد
+
+503
+00:46:39,880 --> 00:46:44,000
+الثامن يطلع مصاب؟» مايجيش واحد يقول «والله عشان
+
+504
+00:46:44,000 --> 00:46:49,680
+ستة طلعوا سليمين إذا راح تكون إحتمالية الإصابة
+
+505
+00:46:49,680 --> 00:46:55,380
+أقل» لأ، بتظلها ربع، ماشي، وهي يعني
+
+506
+00:46:55,380 --> 00:47:03,720
+الـIndependence of outcome يعني باللغة الإحصائية
+
+507
+00:47:04,470 --> 00:47:10,330
+بقولّك اللي هي إن الحدث العشوائي لا يحمل ذاكرة،
+
+508
+00:47:10,330 --> 00:47:17,230
+ماشي؟ فالفكرة في الموضوع أنا والله بفن ورا قطعة
+
+509
+00:47:17,230 --> 00:47:24,350
+نقود ويا إما بتطلع positive يعني وجه يا كتابي، يا
+
+510
+00:47:24,350 --> 00:47:29,850
+صورة يا كتابي فالاحتمالية إذا الأمور كويسة، النص
+
+511
+00:47:30,690 --> 00:47:35,390
+فأفرض أنا فنيتها عشر مرات وكل مرة تطلع وجه وجه وجه
+
+512
+00:47:35,390 --> 00:47:41,650
+وجه وجه وجه طب الـ 11 هل هي برضه راح تطلع وجه ولا
+
+513
+00:47:41,650 --> 00:47:47,350
+شو الاحتمالية؟ بقول بما أنه كل حدث غير مرتبط
+
+514
+00:47:47,350 --> 00:47:55,660
+بالثاني إذا النتيجةرح تكون برضه نص بالنسبة لقطعة
+
+515
+00:47:55,660 --> 00:48:02,900
+النقود إنها تكون وجه ولا كتابة لمن أنا سويتها فهي
+
+516
+00:48:02,900 --> 00:48:10,520
+الحالة A وB لما تكون الأمور معروفة ومفهومة، ماشي؟
+
+517
+00:48:10,520 --> 00:48:15,140
+لو ناخد خيار آخر أو احتمالية آخرة أو عائلة أخرى،
+
+518
+00:48:15,140 --> 00:48:21,500
+إنه أنا بالأولإمرأة اتزوجت رجل جابه طفل مصاب أنا
+
+519
+00:48:21,500 --> 00:48:28,600
+عرفت إنه هي حامل وهذه نسبة إنها تكون حامل للـ
+
+520
+00:48:28,600 --> 00:48:35,720
+Career للـ Genetic Mutation 100% اتزوجت إنسان أنا
+
+521
+00:48:35,720 --> 00:48:40,800
+لسه ما بعرف أو طلقت الجوز الأولاني وارتبطت بشخص
+
+522
+00:48:40,800 --> 00:48:51,300
+آخر الشخص الثاني ماشيأنا ماعندي معلومة عنه، فهؤلاء
+
+523
+00:48:51,300 --> 00:48:57,860
+العائلة الجديدة أتوا يسألوا «ما هي احتمالية أن
+
+524
+00:48:57,860 --> 00:49:04,360
+نجيب طفل مصاب؟» الأمر هنا برتبطبمعرفتنا يعني شو
+
+525
+00:49:04,360 --> 00:49:08,980
+احتمالية هذا الإنسان فهنا الوضع مختلف عن الحالة A
+
+526
+00:49:08,980 --> 00:49:15,880
+وB السبب إنه أنا هنا ما بعرف فديش هذا الإنسان عنده
+
+527
+00:49:15,880 --> 00:49:24,210
+فحاطين يعني هنا بتتغير الأمور بطريقتينفريقة
+
+528
+00:49:24,210 --> 00:49:28,470
+الأولى، أنا لازم أكون أعرف أو عندي معلومة تقريبًا
+
+529
+00:49:28,470 --> 00:49:35,890
+كام نسبة المرض في الـ General Population ماشي،
+
+530
+00:49:35,890 --> 00:49:42,650
+فاللي حاطينه هنا إنه هذا كمثال، ونأخذه كمثال
+
+531
+00:49:42,650 --> 00:49:49,390
+افتراضي إن الـGene هذا موجود في واحد من كل 22 بني
+
+532
+00:49:49,390 --> 00:49:57,770
+آدم فاحتمالية إنه يكونهذا الإنسان عنده جين وراثة
+
+533
+00:49:57,770 --> 00:50:11,370
+المرض هذا 1 على 22 ماشي، فالفكرة اللي لما
+
+534
+00:50:11,370 --> 00:50:20,400
+ناخد الآن يعني الاحتمالات زي ما شُفنا هنالما يكون
+
+535
+00:50:20,400 --> 00:50:27,040
+عندي two events إذا اعتبرناهم نسبهم مختلفة يعني
+
+536
+00:50:27,040 --> 00:50:37,960
+هنا نسبة كام copy من المرض هو نص، ماشي؟ وهنا 1 على
+
+537
+00:50:37,960 --> 00:50:46,260
+22، أظن نضربها ببعض وبيكون يعني بيحسبوا كيف تطلع
+
+538
+00:50:46,260 --> 00:50:55,440
+اللي هي 1 على 88يعني هنا أنا مرة واحدة بضرب النسب
+
+539
+00:50:55,440 --> 00:51:04,020
+الاحتمالية ببعض ونتيجتها يعني بتكون يعني لما نكون
+
+540
+00:51:04,020 --> 00:51:08,720
+يعني أنا الأرقام هنا بالضبط بالضبط في الشرح موجود
+
+541
+00:51:08,720 --> 00:51:13,860
+وحاطينه بالنسبة ليعني لما نقول هنا الـCarrier نسبة
+
+542
+00:51:13,860 --> 00:51:19,420
+100% بس هي الـCarrier عنده one copyماشي، لما أقول
+
+543
+00:51:19,420 --> 00:51:27,980
+1 من 22 عنده الـGene ف1 على 22 تربيع أو 1 على 22
+
+544
+00:51:27,980 --> 00:51:33,840
+يعني نسيت الرقم بحيث إنه لو ضربت احتمالية هذا
+
+545
+00:51:33,840 --> 00:51:40,940
+باحتمالية هذا بتطلع عندي 1 على 88 يعني الرقم هذا
+
+546
+00:51:40,940 --> 00:51:45,200
+هو المطلوب من الـCounselor إنه يقدمه بعد دراسة
+
+547
+00:51:45,200 --> 00:51:51,730
+طبيعة الوراثةوطبيعة المرض
+
+548
+00:51:51,730 --> 00:51:56,470
+وطبيعة الحالة لما أكون بالشكل الأول A وB أنا عارف
+
+549
+00:51:56,470 --> 00:52:00,930
+كل شيء وبالتالي بقدر أحسبه بشكل دقيق هنا بتصير في
+
+550
+00:52:00,930 --> 00:52:08,530
+عندي مجاهيل أكتر فالآن هنا أنا أظن كأنه كاتبين
+
+551
+00:52:08,530 --> 00:52:13,390
+عشان هي تطلع 88 إنه احتمالية إن الواحد يكون حامل
+
+552
+00:52:13,390 --> 00:52:19,530
+للجيل 1 ع 22فتطلع تضرب أربعة لربع و لا كذا تطلع
+
+553
+00:52:19,530 --> 00:52:25,170
+اللي هي 1 على 88 اللي دخلت فيها احتمالية الحدث
+
+554
+00:52:25,170 --> 00:52:33,490
+الآخر لأنه نسبة أخرى يعني مثال أنا باجي معاي قطعة
+
+555
+00:52:33,490 --> 00:52:38,430
+نقود وجه ولا كتابة وعندي حبة Nerd اللي هي المكعب
+
+556
+00:52:38,430 --> 00:52:44,490
+اللي عليه أرقام 0، 1، 1، 2، 3، 4، 6فبقول بمسك
+
+557
+00:52:44,490 --> 00:52:49,550
+اثنين هيك و بزدهم بصير أقول مثلا «شو احتمالية أن
+
+558
+00:52:49,550 --> 00:52:59,690
+يطلع لرقم ست و الفترة الفلوس وجه؟» مش صورة أو صورة
+
+559
+00:52:59,690 --> 00:53:07,550
+مش كتابة يعني مثلا فبقول الصورة هي نص و الـNerd أن
+
+560
+00:53:07,550 --> 00:53:12,910
+يكون اللي تطلع لرقم ست هي واحد من ستةفنص بواحد من
+
+561
+00:53:12,910 --> 00:53:16,970
+ست بيصير واحد باتناش بضربهم مع بعض فالفكرة بهذه
+
+562
+00:53:16,970 --> 00:53:22,270
+الطريقة عشان أنا أقدر شو الاحتمالية الملاحظ هنا
+
+563
+00:53:22,270 --> 00:53:33,090
+إنه إذا في مجهول ماشي يعني هنا اللي حكيناه إنه
+
+564
+00:53:33,090 --> 00:53:36,590
+صحيح أنا هنا كل الست الأولاد هدولة طلعوا سليمين
+
+565
+00:53:36,590 --> 00:53:38,430
+مافيش عندهم مشكلة
+
+566
+00:53:41,990 --> 00:53:49,850
+لما يكون عندى أنا العائلة فيها مجهول أنا مش عارف
+
+567
+00:53:49,850 --> 00:53:55,010
+شو عنده بالضبط لسه ماشي وأخدت الـ General
+
+568
+00:53:55,010 --> 00:54:01,010
+Population Percentage إذا المرأة هذه لما اتزوجت
+
+569
+00:54:01,010 --> 00:54:06,450
+الزلمة التاني جابت منه ست ولاد طلعوا كلهم سليمين،
+
+570
+00:54:06,450 --> 00:54:12,320
+ماشيلأن الـ Fact أنه يعني حقيقة أنه الـ 6 طلعوا
+
+571
+00:54:12,320 --> 00:54:19,240
+سليمين هذا بيخليني أغير نسبة شوه احتمالية أن يكون
+
+572
+00:54:19,240 --> 00:54:24,320
+هذا الإنسان فعلا سليم مية بالمية ومالوش يعني لو
+
+573
+00:54:24,320 --> 00:54:30,540
+كان مثلا قضيني الكلام أنه أنا 1 على 1 على 22 بكون
+
+574
+00:54:30,540 --> 00:54:37,600
+حامل للمرض لأنها general population بس لما يكونست
+
+575
+00:54:37,600 --> 00:54:44,240
+مرات يكون إنه هنا ما يبين إنه حامل معناته إنه أنا
+
+576
+00:54:44,240 --> 00:54:49,880
+بثقة أكبر بقول إنه هذا مش حامل للمرض وبالتالي لما
+
+577
+00:54:49,880 --> 00:54:53,660
+أعمل الحسبة تبعتي وتشوفوها، أقرأوها بقول هنا
+
+578
+00:54:53,660 --> 00:54:59,860
+تقريبًا 1 على 476 يعني تقريبًا 1 على 500 يعني خمس
+
+579
+00:54:59,860 --> 00:55:06,370
+مرات أقل احتمالية إن الطفل الجاي ييجي عنده مرضبسبب
+
+580
+00:55:06,370 --> 00:55:13,110
+أنه الـ 6 إخوان له الأشقاء كلهم سليمين وعنده أخ مش
+
+581
+00:55:13,110 --> 00:55:18,190
+شقيق من أمه من قبل كان عنده المرض هذا فهيك الواحد
+
+582
+00:55:18,190 --> 00:55:23,270
+بده يقراها ويده ينتبه إلها بدها الواحد يكون شاطر
+
+583
+00:55:23,270 --> 00:55:29,250
+بالرياضيات ودارس إحصاء وكويس ماشي أتأمل أني أكون
+
+584
+00:55:29,250 --> 00:55:33,890
+شرحت يعني شو معنى الـ slide هذا بأرقام بهذه
+
+585
+00:55:33,890 --> 00:55:34,410
+المعاني
+
+586
+00:55:37,940 --> 00:55:43,540
+النقطة اللي يعني هنا عقدوا الموضوع بإيش اسمه أكثر
+
+587
+00:55:43,540 --> 00:55:51,400
+قضية الـ Conditional Probability يعني إنه أنا حتى
+
+588
+00:55:51,400 --> 00:55:57,900
+أقيس شو إحتمالية إن حدث معين يكون بشكل معين ماشي
+
+589
+00:55:57,900 --> 00:56:08,850
+بصير، بدي يعني رياضياً أكون عندي قدرة على إنهأحلل
+
+590
+00:56:08,850 --> 00:56:14,650
+الموضوع بشكل سليم الأن
+
+591
+00:56:14,650 --> 00:56:22,030
+المثال اللي حطيناه قبل هو
+
+592
+00:56:22,030 --> 00:56:27,890
+Autism and Recessive لما كان عندي إنسان مصاب،
+
+593
+00:56:27,890 --> 00:56:33,890
+المصاب
+
+594
+00:56:33,890 --> 00:56:39,540
+في الحال هادىوالتزامن الـ Recessive المالز
+
+595
+00:56:39,540 --> 00:56:43,740
+والفيمالز زي بعض ولمّا طلع عندي إنسان مصعب فأنا
+
+596
+00:56:43,740 --> 00:56:48,740
+متأكد 100% إن الأب والأم Carriers هاي Fact، يعني
+
+597
+00:56:48,740 --> 00:56:55,060
+خلاص، انتهينا منها ناخد هنا مثلا موضوع ثاني وهنا
+
+598
+00:56:55,060 --> 00:56:58,180
+اللي هي X-linked recessive اللي هي الـHemophilia
+
+599
+00:56:58,180 --> 00:57:03,160
+اللي هي النعور اللي هي نقص factor eight و factor
+
+600
+00:57:03,160 --> 00:57:10,210
+nine أو factor nineوهي X-linked recessive فأنا
+
+601
+00:57:10,210 --> 00:57:16,890
+أفرض أنا عندي هنا السؤال
+
+602
+00:57:16,890 --> 00:57:25,070
+السؤال هذه المرأة اللي حاطين عليها سهم بتسأل شو
+
+603
+00:57:25,070 --> 00:57:34,290
+احتمالية أني أكون حامل لمرض النعور والهيموفيليا في
+
+604
+00:57:34,290 --> 00:57:42,140
+حالةإنه أنا عارف إن إثنين من إخوالها طلعوا
+
+605
+00:57:42,140 --> 00:57:47,440
+positive يعني إثنين من إخوالها طلعوا positive
+
+606
+00:57:47,440 --> 00:57:53,080
+وطلعوا عندهم المرض وهي بتسأل شو احتمالية تكون عندي
+
+607
+00:57:53,080 --> 00:58:02,420
+وأنا أنقله لأولادي وبناتي فهنا الموضوع ماشي في كذا
+
+608
+00:58:02,420 --> 00:58:15,170
+احتمالالكون أخوالها مصابين، ماشي، معناته إن على
+
+609
+00:58:15,170 --> 00:58:22,250
+الأقل لازم جدتها تكون مصابة فكلمة
+
+610
+00:58:22,250 --> 00:58:27,250
+conditional probability اللي هي يعني إنه أنا إذا
+
+611
+00:58:27,250 --> 00:58:36,080
+عندي كذا ظاهرةوكل واحدة بتحمل احتمالية مختلفة أني
+
+612
+00:58:36,080 --> 00:58:39,700
+أنا بالنسبة
+
+613
+00:58:39,700 --> 00:58:45,640
+لإحتمالية الاحتمالية العامة لحدوث هذا الشيء بما
+
+614
+00:58:45,640 --> 00:58:52,300
+فيها أنه فيه عدم يقين Uncertainty بشكل معين بتشوف
+
+615
+00:58:52,300 --> 00:58:57,120
+احتمالية كل الاحتمالات وبجمعهم بتطلع عندي
+
+616
+00:58:57,120 --> 00:59:04,540
+الاحتمالية الكلية فالمرأة هذه اللي هي هنا عليها
+
+617
+00:59:04,540 --> 00:59:10,280
+السهم اللي هي بتسأل السؤال طبعاً هنا عشان نعرف عن
+
+618
+00:59:10,280 --> 00:59:13,320
+أيش بحكي طبعاً هذا الـ Generation I، Generation
+
+619
+00:59:13,320 --> 00:59:19,960
+II، Generation III الـ Generation دايماً مثلاً II
+
+620
+00:59:19,960 --> 00:59:26,040
+هذا الطفل الأول، الطفل الثاني، هذا جوز البنت هذه
+
+621
+00:59:26,660 --> 00:59:30,020
+وهذا الطفل الثالث أو الـ الـ الـ في الـ generation
+
+622
+00:59:30,020 --> 00:59:35,340
+هذا الشخص الرابع فبعطي أرقام للـ generation وبعطي
+
+623
+00:59:35,340 --> 00:59:40,920
+يعني هذول بالـ Roman numbers وبعطي أرقام للأفراد
+
+624
+00:59:40,920 --> 00:59:44,680
+بترتيب معين عشان أعرف عن مين أنا بحكي وماشي اللي
+
+625
+00:59:44,680 --> 00:59:55,480
+بحكي فالآن المرأة هذه اللي بتسأل ماشي خوالها
+
+626
+00:59:55,480 --> 01:00:02,000
+مصابيناللي هم 2A و2B و2B و2B و2B و2B و2B و2B و2B
+
+627
+01:00:02,000 --> 01:00:08,400
+و2B و2B و2B و2B و2B و2B و2B و2B و2B و2B و2B و2B
+
+628
+01:00:08,400 --> 01:00:09,920
+و2B و2B و2B و2B و2B و2B و2B و2B و2B و2B و2B و2B
+
+629
+01:00:09,920 --> 01:00:10,600
+و2B و2B و2B و2B و2B و2B و2B و2B و2B و2B و2B و2B
+
+630
+01:00:10,600 --> 01:00:11,000
+و2B و2B و2B و2B و2B و2B و2B و2B و2B و2B و2B و2B
+
+631
+01:00:11,000 --> 01:00:16,360
+و2B و2B و2B و2B و2B و2B و2B و2B و2B و2B
+
+632
+01:00:16,360 --> 01:00:24,120
+و2B و2B و2B و2B و2B و2B و2
+
+633
+01:00:24,230 --> 01:00:28,890
+يعني هذه البنت هنا اللي بدأت تتجوز وتسأل «شو وضعي
+
+634
+01:00:28,890 --> 01:00:34,170
+أنا؟» «شو اللي بيصير عندي؟» «شو كذا؟» فإن إخوالها
+
+635
+01:00:34,170 --> 01:00:40,830
+أكيد مصابي، طب إمها مصابة ولا لأ؟ فهنا حاطين
+
+636
+01:00:40,830 --> 01:00:48,430
+احتمال إن الإم مش مصابة أو الإم مصابةوبعد أن أمها
+
+637
+01:00:48,430 --> 01:00:52,830
+مصابة، هل هي مصابة أو ليس مصابة؟ فصار عندي ثلاث
+
+638
+01:00:52,830 --> 01:00:58,970
+خيارات، ثلاث احتمالات إنه ممكن الجد أصيبت، بس ما
+
+639
+01:00:58,970 --> 01:01:05,230
+نقلت لبنتها فبنتها طلعت Clear، Normal وبالتالي 100
+
+640
+01:01:05,230 --> 01:01:14,630
+% الحفيدة ما راح تكون مصابة ممكن الأم الجد مصابة،
+
+641
+01:01:14,630 --> 01:01:19,940
+نقلت لبنتهاوبنتها الحالة الأولى هو إنها ما نقلتش
+
+642
+01:01:19,940 --> 01:01:26,520
+لحفيدتها للجدة فهذا احتمال ثاني وفي احتمال تالت لأ
+
+643
+01:01:26,520 --> 01:01:30,200
+إنه نقلت لهجي فانت صار عندي تلت خيارات و تلت
+
+644
+01:01:30,200 --> 01:01:36,520
+احتمالات ماشي الانسان
+
+645
+01:01:36,520 --> 01:01:42,260
+اللي هنا بيسموها الـ Joint Probabilities ماشي ال
+
+646
+01:01:42,260 --> 01:01:50,040
+.. ال ..الاحتمالية للحالة الأولى أنه يكون هاي أكيد
+
+647
+01:01:50,040 --> 01:01:53,920
+عندها one copy فهنا احتمالية أنها عندها اللي تكون
+
+648
+01:01:53,920 --> 01:02:00,960
+ال copy راح تصير نص، ماشي؟ والاحتمالية أنه تاخد من
+
+649
+01:02:00,960 --> 01:02:08,240
+أمها برضه احتمالية نص، ماشي؟ فالـ Joint
+
+650
+01:02:08,240 --> 01:02:15,750
+Probability بدنا نضربهم في بعضنص في نص أربعة يعني
+
+651
+01:02:15,750 --> 01:02:22,610
+هدولة الاحتماليات اللي يعني أنا لو جدة عندها one
+
+652
+01:02:22,610 --> 01:02:29,430
+copy ماشي بنتها أنها تكون يعني هي نص يعني واحدة من
+
+653
+01:02:29,430 --> 01:02:33,950
+اثنتين البنت أن تكون عندها ال copy بتقول
+
+654
+01:02:33,950 --> 01:02:40,210
+احتماليتها ربع واتزوجت من شخص آخر وحفيدة الأصل
+
+655
+01:02:40,210 --> 01:02:45,740
+الواحد يقول ثمنفإحنا نحكي برقم عشوائي، لأ، بتقول
+
+656
+01:02:45,740 --> 01:02:49,960
+ثمن، بس هذا غلط، مش المظبوط إن الواحد يقولها بس
+
+657
+01:02:49,960 --> 01:02:55,160
+ثمن ويحطها بهذا الشكل، بحط الواحد الاحتمالات
+
+658
+01:02:55,160 --> 01:03:02,420
+الثلاثة وبدرب الاحتماليات الخطوات تبعتهم، ماشي،
+
+659
+01:03:02,420 --> 01:03:11,320
+وهنا بطبق مبدأ إنه أنا عندي يعنيمعرفة إنه فيه
+
+660
+01:03:11,320 --> 01:03:18,200
+أشخاص آخرين ما عندهم مش ماشي يعني بظل إنه فيه
+
+661
+01:03:18,200 --> 01:03:23,280
+احتمال إنه شخص مش مصاب حسب يا ما الـ General
+
+662
+01:03:23,280 --> 01:03:27,640
+Population أو زي ما حكينا بالمثال قبل شوية اللي هو
+
+663
+01:03:27,640 --> 01:03:31,380
+إنه لما العيلة التانية جابوا ست أفراد ماعندهم مش
+
+664
+01:03:31,380 --> 01:03:38,680
+إصابة فاحتمالية الإصابة أقل الـ الـ النتيجةإنه
+
+665
+01:03:38,680 --> 01:03:41,860
+يعني هنا
+
+666
+01:03:41,860 --> 01:04:05,180
+الـ………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………
+
+667
+01:04:07,480 --> 01:04:17,260
+ولمّا تأخذ، يعني هي بالأصل 1 على 64، وبعدين 1 على
+
+668
+01:04:17,260 --> 01:04:23,900
+34 وهنا الاحتمال الثاني، يعني احتمالية أن الجد
+
+669
+01:04:23,900 --> 01:04:30,260
+مصابي اتجوزت واحد مش مصاب، وبعدين البنت اتجوزت
+
+670
+01:04:30,260 --> 01:04:38,120
+واحد مش مصاب، وهي أجت البنتالبنت بتسأل، طبعاً هي
+
+671
+01:04:38,120 --> 01:04:42,180
+كمان بدأت تتجوز بواحد مش مصاب، هيك الأصل احتمالية
+
+672
+01:04:42,180 --> 01:04:46,920
+أنه تنقل المرض 1 على 43، هي احتمالية هذه الحالة،
+
+673
+01:04:46,920 --> 01:04:53,900
+هذه الخطوة الـ B بتكون احتماليتها كمان 1 على 34
+
+674
+01:04:54,900 --> 01:04:59,580
+واحتمالية إن الجد مصابي بس ماعتدتش لبنتها والبنت
+
+675
+01:04:59,580 --> 01:05:06,420
+بعدين ماعتدتش للحفيدة هو 16 على 17 يعني 32 على 34
+
+676
+01:05:06,420 --> 01:05:11,640
+الفكرة أنه بعد ما عرفنا معلومات أكتر بقدر أصير
+
+677
+01:05:11,640 --> 01:05:17,840
+أعمل رياضيات وأحصاء بشكل أفضل والنتيجة
+
+678
+01:05:17,840 --> 01:05:25,650
+النهائية أنه لما أجمع هذول النتائجواحد على أربعة
+
+679
+01:05:25,650 --> 01:05:28,510
+وثلاثين وواحد على أربعة وثلاثين وستاشر على سبعتاش
+
+680
+01:05:28,510 --> 01:05:33,930
+بيطلعلي 100% الاحتمال الكلي فهدولة اللي بيسموها
+
+681
+01:05:33,930 --> 01:05:38,310
+Bayesian calculation وهدولة أنواع من الرياضيات
+
+682
+01:05:38,310 --> 01:05:47,290
+بنصير نسويهم عشان نحسب شو احتمالية أنه البنت تكون
+
+683
+01:05:47,290 --> 01:05:53,720
+يعني مصابة وشو احتمالية أنها تنقلها لأهلهافهنا
+
+684
+01:05:53,720 --> 01:05:59,020
+دايمًا يعني هذا
+
+685
+01:05:59,020 --> 01:06:04,100
+مثال على مرض زي الـ Hemophilia واحتمال يعني على
+
+686
+01:06:04,100 --> 01:06:11,740
+الأمور الرياضية اللي فيها بالنسبة كوراثة جين
+
+687
+01:06:11,740 --> 01:06:17,180
+مفهوم، Single gene، Mendelian أنا عارف عنه وبعرف
+
+688
+01:06:17,180 --> 01:06:25,680
+كيفإن شاء الله إذا بقول يعني بالنسبة للـSlides هذه
+
+689
+01:06:25,680 --> 01:06:32,540
+إذا مافهمتوش مني 100% بسأل الـOrganizer واللي
+
+690
+01:06:32,540 --> 01:06:38,440
+معاكم يعني هو لو قريت اللي في الكتاب بمفهومه بشكل
+
+691
+01:06:38,440 --> 01:06:42,400
+جيد يمكن أنا مش شاطر كتير في الشبه، بالذات في هذا
+
+692
+01:06:42,400 --> 01:06:48,210
+الموضوعوالشغل الثاني أنه بدك واحد بيفهم بالأحصاء
+
+693
+01:06:48,210 --> 01:06:54,090
+بيفهم بالاحتمالات يدخل معاك واحد واحدة ويكون يشوف
+
+694
+01:06:54,090 --> 01:07:02,250
+ليش بنسويها بهذه الطريقة وبتكون أنه الـ الـ الـ
+
+695
+01:07:02,250 --> 01:07:08,030
+النتائج بتكون بهذا الشكل الاحتمال أو التعقيد اللي
+
+696
+01:07:08,030 --> 01:07:18,440
+بعد ذلك هو يعنيحالات بتتكلموا عن مرض
+
+697
+01:07:18,440 --> 01:07:22,820
+أنا لسه مش عارف يعني الحالة الأولى Autism and
+
+698
+01:07:22,820 --> 01:07:27,920
+Recessive وأنا عارف عنه وعارف الجيل وأنا متأكد أن
+
+699
+01:07:27,920 --> 01:07:31,400
+الأب والأم لازم يكونوا Carriers حتى يحدث المرض
+
+700
+01:07:31,400 --> 01:07:36,800
+وأنا عارف الـInheritance تبعه فهذه قصة حلوة لما
+
+701
+01:07:36,800 --> 01:07:42,900
+يكون الزوج الثاني مش معروف يصير الموضوع أعقبأما
+
+702
+01:07:42,900 --> 01:07:47,900
+لما يكون عندى كمان مجاهيل أكثر بيصير بده إحصاء
+
+703
+01:07:47,900 --> 01:07:52,660
+أصعب وبالنتيجة بتكون يعني معقدة أكتر بدى الواحد
+
+704
+01:07:52,660 --> 01:08:02,100
+يتبع معاهم بالنسبة لأرقام كيف بتكون الـ… الـ… الـ…
+
+705
+01:08:02,100 --> 01:08:08,050
+الـB-degree الثالث أو النموذج الثالث أو الرابعهو
+
+706
+01:08:08,050 --> 01:08:15,830
+إذا عائلة عندهم مرض نادر أو مش معروف ننتبه بس بقول
+
+707
+01:08:15,830 --> 01:08:22,070
+في الـ «سلايد» هذا إنه أنا جزء من تعاملي مع
+
+708
+01:08:22,070 --> 01:08:28,490
+الاحتمالية هنا بكون باعتمد على رقمين الرقم الأول
+
+709
+01:08:28,490 --> 01:08:36,900
+شوه احتمالية إنه المرضهو نتيجة جين موروث في
+
+710
+01:08:36,900 --> 01:08:40,840
+المجتمع يعني زي اللي حكينا عنه الـ Hemophilia و
+
+711
+01:08:40,840 --> 01:08:43,960
+الـ Bq لأن الـ Autism is recessive أو Existently
+
+712
+01:08:43,960 --> 01:08:47,700
+recessive و لا كذا، ماديش نسبة و واحد في المية و
+
+713
+01:08:47,700 --> 01:08:52,300
+واحد في العشرة و واحد في الألف و بدنا نلاحظ هذا
+
+714
+01:08:52,300 --> 01:08:59,020
+يتم توريطه بس في عندي احتمالية ثانية اللي هي New
+
+715
+01:08:59,020 --> 01:09:05,360
+Mutation من حالهابتنشأ وشوه احتمالية أنه تنشأ هذه
+
+716
+01:09:05,360 --> 01:09:11,320
+الـ mutation الجديدة يعني بيكون مش نتيجة ورافة
+
+717
+01:09:11,320 --> 01:09:19,220
+لازمة من الأباء والأمهات فهنا التعقيد راح يصير أنه
+
+718
+01:09:19,220 --> 01:09:27,440
+الاحتمالية الجين في المجتمع وهنا بيسموه H ماشي؟
+
+719
+01:09:30,260 --> 01:09:37,740
+والاحتمالية إنه New Mutation نسمينه الـ Mu فبصير
+
+720
+01:09:37,740 --> 01:09:44,480
+عندي أرقام مختلفة وهنا حاطين مثال
+
+721
+01:09:44,480 --> 01:09:50,020
+X-Linked Genetic Lethal Disorder شو يعني؟ يعني هنا
+
+722
+01:09:50,020 --> 01:09:56,620
+حالة إن هذا الذكر اللي مصاب لأنه X-Linked
+
+723
+01:09:56,620 --> 01:10:04,120
+RecessiveLethal يعني ما راح يعيش أو الـ «دوشين
+
+724
+01:10:04,120 --> 01:10:08,920
+مسكولر دستروفي» الأطفال اللي بولدوا من أولها
+
+725
+01:10:08,920 --> 01:10:14,440
+بيبينوا ضعاف، عضلاتهم ضامرة ويتوبك على سن العشر
+
+726
+01:10:14,440 --> 01:10:19,040
+سنين نسبة عالية جدا، كلهم بموتوا العشر سنين قبل ما
+
+727
+01:10:19,040 --> 01:10:22,800
+يبلغوا قبل ما يصير في احتمالية أنه يخلفوا هم
+
+728
+01:10:22,800 --> 01:10:27,560
+بحالهم فالـ «دوشين مسكولر دستروفي» في حالة زي هيك
+
+729
+01:10:28,300 --> 01:10:38,080
+الـ … الـ … الـ … الوجود طفل عنده هذه الحالة
+
+730
+01:10:38,080 --> 01:10:43,800
+فمتيجي الأهل يسأله «طب، و بعد ذلك المرة الثانية،
+
+731
+01:10:43,800 --> 01:10:48,820
+شو الاحتماليات؟ و شو كذا؟» أنا هنا بصير أدخل إنه
+
+732
+01:10:48,820 --> 01:10:56,260
+فيه احتمال إنه الـ … الـ … الأم، ماشي، هي career
+
+733
+01:10:58,120 --> 01:11:03,240
+هنا زي في الاحتمال رقم 2 بس الاحتمال إنه لأ هي مش
+
+734
+01:11:03,240 --> 01:11:07,280
+career وإنها صارت mutation في الطفل نفسه بس بما
+
+735
+01:11:07,280 --> 01:11:11,200
+أنه X-linked و One copy وصار mutation وال copy
+
+736
+01:11:11,200 --> 01:11:17,640
+طلعت مضروبة بصير إن هنا يعني ال mutation عنده وهي
+
+737
+01:11:17,640 --> 01:11:24,280
+تحدث بالنسبة ميو بالتالي يعني بدنا نتكلم عن
+
+738
+01:11:24,280 --> 01:11:28,430
+احتماليه بهذه الطريقة يعني هناإن الأم والأب ما حدش
+
+739
+01:11:28,430 --> 01:11:31,410
+منهم career ما حدش عنده إشي فهي mutation في الطفل
+
+740
+01:11:31,410 --> 01:11:41,950
+نفسه هنا الأم هي عبارة عن شو اسمه career وبالتالي
+
+741
+01:11:41,950 --> 01:11:47,830
+نقلة المرض لإبنها في احتمالية ثالثة إن مثلا لو
+
+742
+01:11:47,830 --> 01:11:55,490
+جدته يعني عنده من أخواله حدا مصابماشي، يعني هذه
+
+743
+01:11:55,490 --> 01:11:59,350
+المرأة هنا حامل بس إحنا ماعرفناش إذا في لأخوان
+
+744
+01:11:59,350 --> 01:12:05,730
+آخرين، يعني أخوان الولد هذا كان حد توفى بهذا
+
+745
+01:12:05,730 --> 01:12:11,550
+المرض، ماشي، ويعني كان في شخص آخر، فإذا كان من
+
+746
+01:12:11,550 --> 01:12:14,970
+أخوان المصابين بتصير إنه آه والله الجد كمان كانت
+
+747
+01:12:14,970 --> 01:12:19,010
+مصابة، فبنلاحظ إنه
+
+748
+01:12:21,830 --> 01:12:23,970
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+749
+01:12:23,970 --> 01:12:24,270
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+750
+01:12:24,270 --> 01:12:24,310
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+751
+01:12:24,310 --> 01:12:24,630
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+752
+01:12:24,630 --> 01:12:29,030
+الـ الـ
+
+753
+01:12:29,030 --> 01:12:33,430
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+754
+01:12:33,430 --> 01:12:35,150
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+755
+01:12:35,150 --> 01:12:35,550
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+756
+01:12:35,550 --> 01:12:37,250
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+757
+01:12:37,250 --> 01:12:37,250
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+758
+01:12:37,250 --> 01:12:38,070
+الـ الـ
+
+759
+01:12:43,650 --> 01:12:48,050
+الجد هي اللي كانت مصابة نقلتها للبنتها ومن بنتها
+
+760
+01:12:48,050 --> 01:12:54,150
+للحفيد أصابته بالمرض فاحتمالية الثلاث حالات هذه
+
+761
+01:12:54,150 --> 01:12:58,310
+راح تيجي تتجمع لـ 100% لأن هاي كل اللي بصوا بالـ
+
+762
+01:12:58,310 --> 01:13:02,790
+Combinations ولمّا نيجي نحسب شو هو احتمالية الطفل
+
+763
+01:13:02,790 --> 01:13:06,550
+اللي بعده أو شو هو احتمالية إنه كذا بتحسب مين اللي
+
+764
+01:13:06,550 --> 01:13:10,690
+طالب الاستشارة ممكن نعطيه الأرقام حسب الدراسة
+
+765
+01:13:12,890 --> 01:13:19,590
+فيعني نتيجة الشغل هذا بنلاقي إنه مثلًا لو ناخد
+
+766
+01:13:19,590 --> 01:13:27,050
+موضوع زي الـ Birth Defect اللي هم يعني العيوب
+
+767
+01:13:27,050 --> 01:13:31,410
+الخلقية بالنسبة للأشياء زي Cleft Lip ولا Cleft
+
+768
+01:13:31,410 --> 01:13:33,750
+Palate ولا Congenital Heart Disease ولا كده
+
+769
+01:13:33,750 --> 01:13:42,970
+الـConsanguinity بتزيد نسبة الاحتمالية هذهفلو جينا
+
+770
+01:13:42,970 --> 01:13:50,030
+أخدنا ألف وليد جديد، الموليد الجدد إن يكون فيه
+
+771
+01:13:50,030 --> 01:13:57,310
+birth defect من هذه الأنواع، ماشي تطلع تقريبًا 1.5
+
+772
+01:13:57,310 --> 01:14:07,730
+%، 15 حالة لما نكون الزواج متباعد، يعني 1% إذا كان
+
+773
+01:14:07,730 --> 01:14:12,520
+في الـFirst Cousin Marriage أكثر من الضعفبتصير
+
+774
+01:14:12,520 --> 01:14:21,260
+احتمالية أن يكون فيه birth defect فهو نتلعت 36 في
+
+775
+01:14:21,260 --> 01:14:31,160
+الألف وإذا الطفل يعني couple زوج أجاهم أول طفل كان
+
+776
+01:14:31,160 --> 01:14:39,080
+مصاب ماشي لو فيه ألف من هدول العيلة ألف عيلة كان
+
+777
+01:14:39,080 --> 01:14:46,160
+عندهم طفل مصاب أولإنه يكون مصاب ثاني بيكون تلاتين
+
+778
+01:14:46,160 --> 01:14:52,040
+في الألف يعني تلاتة بالمية يعني ضعف هدولة ولمّا
+
+779
+01:14:52,040 --> 01:14:57,300
+يكون فيه Consanguinity يعني هنا تقريبًا أربع مرات
+
+780
+01:14:57,300 --> 01:15:03,540
+ونص أقل شويه من خمس مرات ماشي بيصير الزيادة فإيه
+
+781
+01:15:03,540 --> 01:15:07,200
+يعني النقطة اللي بدنا نفهمها هنا جزء من الموضوع
+
+782
+01:15:07,200 --> 01:15:14,440
+أنهدواج الأقارب بزيد احتمالية إن يكون فيه أمراض
+
+783
+01:15:14,440 --> 01:15:23,190
+وراثية تظهر وبيكون يعني رياضياً وهنا كتجربةمن
+
+784
+01:15:23,190 --> 01:15:31,710
+إحصائية ودراسة للموليد حسب درجة قرابة العائلة بين
+
+785
+01:15:31,710 --> 01:15:36,530
+الزوجين وحسب التاريخ السابق إنه كان هناك إصابة من
+
+786
+01:15:36,530 --> 01:15:46,050
+هذا النوع أو لا كلها تزيد النقطة هذه يعني الفصل
+
+787
+01:15:46,050 --> 01:15:53,500
+هذاالكلام أنا بظن عن ناحية مهمة جداً ولازم يكون في
+
+788
+01:15:53,500 --> 01:15:59,220
+كل وزارة الصحة في كل مجموعة صحية بتهتم بـ
+
+789
+01:15:59,220 --> 01:16:07,140
+Population معينة في مجتمع إنه يكون فيه ناس بتعمل
+
+790
+01:16:07,140 --> 01:16:11,340
+Genetic Counseling وجزء من الـ Genetic Counseling
+
+791
+01:16:11,340 --> 01:16:19,480
+إنه كمان نعملنعطي تقييم إحصائي رقمي بشو احتمالية
+
+792
+01:16:19,480 --> 01:16:23,860
+إنه يكون الإنسان حامل للـGene شو احتمالية الإصابة
+
+793
+01:16:23,860 --> 01:16:30,440
+في أي شخص حسب العلوم والرياضيات والأرقام بالشكل
+
+794
+01:16:30,440 --> 01:16:37,500
+اللي حكيناوبتختلف إذا أنا بعرف أنه بثقة أو شيء
+
+795
+01:16:37,500 --> 01:16:42,680
+مجهول فيه ولا مافيش بحط كل الاحتمالات وبدرسها
+
+796
+01:16:42,680 --> 01:16:55,080
+ويعني على ضوءها بصير أتكلم بشكل علمي في أسئلة؟ في
+
+797
+01:16:55,080 --> 01:17:01,060
+حد عنده استفسار النقطة هذه، النقاط هنا أنا بقترح
+
+798
+01:17:01,490 --> 01:17:07,410
+الكتاب عندكم كمان يعني أنا حاولت أفهم الـ «general
+
+799
+01:17:07,410 --> 01:17:14,290
+idea» وطريقة الـ «approach» يعني اللي هي أنه بدي
+
+800
+01:17:14,290 --> 01:17:21,010
+أسير حتى لما يسألوني شو احتمالية كذا لشخص معين بدي
+
+801
+01:17:21,010 --> 01:17:26,200
+أخد كل شجرة العيلة بدي أشوف شو احتمالية الـهل هي
+
+802
+01:17:26,200 --> 01:17:32,260
+زي الـGeneral Population لهذا الموضوع؟ ولا فيه
+
+803
+01:17:32,260 --> 01:17:36,400
+محددات أكثر؟ وبدخل كل الاحتمالات البعض وبطلع
+
+804
+01:17:36,400 --> 01:17:45,160
+الرقم؟ فضل، إذا حد عنده سؤال يعني
+
+805
+01:17:45,160 --> 01:17:48,880
+يا دكتور، هذه النقاط مطالبين فيها أنه في الامتحان
+
+806
+01:17:48,880 --> 01:17:52,000
+نتوسع ولا فقط نلتزم باللي أنت شرحت فيها هذه
+
+807
+01:17:52,000 --> 01:17:58,890
+النقاط؟مش داخل في الموضوع، وش اسمه؟ يعني، هيك ما
+
+808
+01:17:58,890 --> 01:18:04,770
+بدك تكوني فاهماني يعني، لما حكيت والله أنا معايا
+
+809
+01:18:04,770 --> 01:18:11,150
+فيدي قطعة فلوس وجه ولا كتابة وحجر نرد عليه ست
+
+810
+01:18:11,150 --> 01:18:16,330
+أوجه، من واحد لستة، شو احتمالية تطلعلي رقم ست زائد
+
+811
+01:18:16,330 --> 01:18:23,000
+يطلعلي الفلوس تطلعلي وجهي؟ ماشي؟فاهم علي؟ فبدك
+
+812
+01:18:23,000 --> 01:18:26,640
+تكون ليه واحد عطناش، هيك المفروض يعني يبدوا الواحد
+
+813
+01:18:26,640 --> 01:18:30,740
+شوية رياضيات يكون فاهمانها، فالمطالبين مش
+
+814
+01:18:30,740 --> 01:18:37,120
+المطالبين، أنا الصراحة يعني اللي بدي أحاول أسويه
+
+815
+01:18:37,120 --> 01:18:44,320
+اللي هو الموضوع إنه زي ما الـ US M&E كاتبي لكم إن
+
+816
+01:18:44,320 --> 01:18:49,940
+هذا بيجي، بدي أقول، بدي أجيب زيه، ماشي؟ فهذه ناحية
+
+817
+01:18:49,940 --> 01:18:57,880
+ثانيةالناحية الثالثة، يعني اللي شفتيها بتتكلم عن
+
+818
+01:18:57,880 --> 01:19:00,500
+الـPosterior Probability والـConditional
+
+819
+01:19:00,500 --> 01:19:05,260
+Probability يعني هدولة مفاهيم في الإحصاء أنا بهمن
+
+820
+01:19:05,260 --> 01:19:10,540
+الواحد يكون فهما عن المفهوم، ماشي؟ الرقم والخساب
+
+821
+01:19:10,540 --> 01:19:16,560
+والضرب يعني مرات حتى الواحد بغلط فيه وبنقل الأرقام
+
+822
+01:19:16,560 --> 01:19:22,220
+ولّا، بس الفكرة أنه بدي الواحد يحطها كمثالماشي،
+
+823
+01:19:22,220 --> 01:19:26,240
+ويحطها كشيء مفهوم، هم اللي حطوا مثالين كلها
+
+824
+01:19:26,240 --> 01:19:29,760
+تقريبًا Autosomal Recessive أو إذا فيه lethal ولا
+
+825
+01:19:29,760 --> 01:19:33,100
+كده فعندنا إيش اسمه Conditional Probability ولا
+
+826
+01:19:33,100 --> 01:19:40,480
+كده، هسة أتأمل إنه إذا قريتي، تفهمي، ماشي، وإذا
+
+827
+01:19:40,480 --> 01:19:44,810
+الواحد فهم، مش غلطوإذا من 100 سؤال حطيتلي سؤال على
+
+828
+01:19:44,810 --> 01:19:49,330
+إيش زي هيك، يمكن يطلعت شويه صعب، يمكن كذا، ما هو
+
+829
+01:19:49,330 --> 01:19:52,950
+عشان نفرق الشاطر من اللي أقل شطارة، يعني إيش بده
+
+830
+01:19:52,950 --> 01:19:58,510
+أسوء؟ ماشي، أما مطلوب، مش مطلوب، لأ، ما بقدرش
+
+831
+01:19:58,510 --> 01:20:02,090
+أجاوب، عارفش، كل شيء بحقك –أميسيا يا دكتور، أنا
+
+832
+01:20:02,090 --> 01:20:05,310
+كان قصدي إنه هل نتوسع فيه أكتر ولا نلتزم بس باللي
+
+833
+01:20:05,310 --> 01:20:11,830
+شرحته أو كذا؟لأ، كل مثال من الأمثل اللي جبت لهم
+
+834
+01:20:11,830 --> 01:20:17,270
+الصور تبعتهم صراحة معاه شرح أنا شفته سهل جدا يعني
+
+835
+01:20:17,270 --> 01:20:22,270
+بحكي الـ «إنت المفهوم اللي بده أحد يعرفه اللي هو
+
+836
+01:20:22,270 --> 01:20:25,970
+conditional probability و posterior probability»
+
+837
+01:20:25,970 --> 01:20:31,290
+الـconditional إنه أنا بسير أحط الاحتمالات كلهم
+
+838
+01:20:31,290 --> 01:20:41,090
+وبالأخير مجموعهم لازم يكون واحدلازم يكون لأنه لما
+
+839
+01:20:41,090 --> 01:20:46,690
+يحصل حدث معين فاحتمالية حدوثه صارت واحد بس الطرق
+
+840
+01:20:46,690 --> 01:20:51,290
+اللي قدت لهذا الأمر بتكون مختلفة يعني هي مرات هذه
+
+841
+01:20:51,290 --> 01:20:57,370
+كنة المصاري أو الـ Dice اللي هو الـ Nerd اللي من
+
+842
+01:20:57,370 --> 01:21:02,950
+ست أوجه يطلع وجهه و لا كتابه و لا كذا و لا كذايعني
+
+843
+01:21:02,950 --> 01:21:08,830
+هذه القريبة من الموضوع هذا وبناخدها كأمثلة بسيطة
+
+844
+01:21:08,830 --> 01:21:13,750
+يعني بس الـ الـ الـ لما نكون مثلا الحادثين
+
+845
+01:21:13,750 --> 01:21:21,770
+المختلفة يعني هنا الأم اللي اتجوزت واحد مش معروف
+
+846
+01:21:21,770 --> 01:21:29,410
+فهو مصاب ولا مش مصاب الأم زي قطعة الفلوس يا وجهها
+
+847
+01:21:29,410 --> 01:21:34,080
+كتابة وأنا عارف أن يا وجهها كتابةما فيش غيرهم وإذا
+
+848
+01:21:34,080 --> 01:21:38,520
+الأمور عادلة وما فيش فيها غش راح يكون الاحتمالية
+
+849
+01:21:38,520 --> 01:21:45,000
+نص الحدث الثاني اللي هو زي حجر نر يعني الاحتمالية
+
+850
+01:21:45,000 --> 01:21:50,600
+واحد من ست صارت ما كانت واحد من اتنين ماشي ومرات
+
+851
+01:21:50,600 --> 01:21:55,440
+يعني ممكن صياغة السؤال يكون يعطيكي clue أو يعطيكي
+
+852
+01:21:55,440 --> 01:22:02,290
+مفهوم معين إنه شيء معين حدث، ماشي؟وقضية الـ
+
+853
+01:22:02,290 --> 01:22:07,430
+«memorylessness
+
+854
+01:22:07,430 --> 01:22:15,510
+of independent events» فهي قضية مفهومة معروفة يعني
+
+855
+01:22:15,510 --> 01:22:22,530
+مثلا عيلة ست مرات جابت ولاد ذكور شو احتمالية الولد
+
+856
+01:22:22,530 --> 01:22:28,910
+السابع يطلع عنده ذكر؟ شو رأيك؟ نص، بيبقى له نص
+
+857
+01:22:28,910 --> 01:22:34,030
+دايمابظله نص بما هو، لو مليون مرة طلع ذكر وكل مرة
+
+858
+01:22:34,030 --> 01:22:39,410
+ذكر وبعدين يجي واحد يقول لأ اللي مرة هذه لازم يطلع
+
+859
+01:22:39,410 --> 01:22:42,370
+ذكر لأنه مليون مرة من قبل طلع ذكر لأ ما بتمشي
+
+860
+01:22:42,370 --> 01:22:47,470
+الأمور هكذا، هذا إذا الأمور ما لها دخلت بعض وتكون
+
+861
+01:22:47,470 --> 01:22:52,010
+الأمور محكومة ومعروفة، بس إذا أنا عندي إشي مجهول
+
+862
+01:22:52,010 --> 01:22:57,940
+وبدرسهماشي ويصير مثلًا أنه لو احتملنا أنه
+
+863
+01:22:57,940 --> 01:23:02,700
+اعتبرناها الأمور independent وكل واحد بالاصل fifty
+
+864
+01:23:02,700 --> 01:23:09,590
+fifty شو احتمالية يعني أنا إذا بتنتبهي دكتورةلما
+
+865
+01:23:09,590 --> 01:23:16,790
+نجي نعمل تجربة ونقول والله بنحط الـ… بتاخدتوا
+
+866
+01:23:16,790 --> 01:23:19,830
+الـResearch Principles وبتحط اللي بيسموه الـNull
+
+867
+01:23:19,830 --> 01:23:23,450
+Hypothesis والـAlternative Hypothesis وبتعملوا
+
+868
+01:23:23,450 --> 01:23:26,510
+الـStatistical Test وبتطلعوا الـP-Value اللي هي
+
+869
+01:23:26,510 --> 01:23:31,770
+نسبة التأكد إن هذا الأمر مش نتيجة صدفةبتكون نسبة
+
+870
+01:23:31,770 --> 01:23:39,890
+المطلوبة إنه يكون عندى الاحتمالية أقل من 5% هذه
+
+871
+01:23:39,890 --> 01:23:44,070
+الاحتمالية الصدفة المقبولة للدراسات العلمية
+
+872
+01:23:44,070 --> 01:23:51,570
+فالموضوع بتلاقي أنا بقول إذا بنجيب إنه واحد عشان
+
+873
+01:23:51,570 --> 01:23:56,230
+تقول بشكل علمي مقبول بهذه الطريقة إنه لما أفن
+
+874
+01:23:56,230 --> 01:24:02,250
+لقطعة الفلوس تطلع وجههأو صورة مش كتابة لازم أفنها
+
+875
+01:24:02,250 --> 01:24:07,170
+على الأقل ست مرات وكل مرة تطلع وجه، وجه، وجه، وجه،
+
+876
+01:24:07,170 --> 01:24:08,330
+وجه، وجه، وجه، وجه، وجه، وجه، وجه، وجه، وجه، وجه،
+
+877
+01:24:08,330 --> 01:24:13,030
+وجه، وجه،
+
+878
+01:24:13,030 --> 01:24:15,830
+وجه، وجه، وجه، وجه، وجه، وجه، وجه، وجه، وجه، وجه،
+
+879
+01:24:15,830 --> 01:24:16,450
+وجه، وجه، وجه، وجه، وجه، وجه، وجه، وجه، وجه، وجه،
+
+880
+01:24:16,450 --> 01:24:16,450
+وجه، وجه، وجه، وجه، وجه، وجه، وجه، وجه، وجه، وجه،
+
+881
+01:24:16,450 --> 01:24:16,450
+وجه، وجه، وجه، وجه، وجه، وجه، وجه، وجه، وجه، وجه،
+
+882
+01:24:16,450 --> 01:24:22,530
+وجه، وجه، وجه، وجه، وجه، وجه، وجه، وج
+
+883
+01:24:27,700 --> 01:24:33,900
+ثلاث مرات، معناتها صارت إيه اسمه؟ إتناش و نص
+
+884
+01:24:33,900 --> 01:24:39,460
+بالمية أربع مرات، ست و ربع بالمية حتى تكون تحت
+
+885
+01:24:39,460 --> 01:24:43,120
+الخمس بالمية، بديك خمس مرات، ست مرات عشان تثبت إن
+
+886
+01:24:43,120 --> 01:24:47,020
+الـP-Value بتطلع بهذا الشكل فإحنا نتكلم من هذه
+
+887
+01:24:47,020 --> 01:24:54,360
+النواحي أنا مش إحنا course probability وإحصاء وكذا
+
+888
+01:24:54,360 --> 01:25:01,500
+المهم الـGeneral Ideaالـ Counselor اللي بعمل
+
+889
+01:25:01,500 --> 01:25:08,640
+Counseling لعيلة لازم يكون عنده آلات وفهم واستيعاب
+
+890
+01:25:08,640 --> 01:25:16,980
+على إنه يعمل الدراسة الإحصائية ويطلع تقدير ماشي
+
+891
+01:25:16,980 --> 01:25:23,200
+ويبلغ الأهل فيه، هذه النقطة المطلوبةما مثل ما يا
+
+892
+01:25:23,200 --> 01:25:29,100
+دكتور الله يحييكم في أسئلة في نفس المثال أو في نفس
+
+893
+01:25:29,100 --> 01:25:31,460
+الأشياء مش مطلوب ولا مش مطلوب؟ يعني ما انتوا
+
+894
+01:25:31,460 --> 01:25:35,820
+سألوني مش هذا السؤال آه لأ لأ كله واضح إن شاء الله
+
+895
+01:25:35,820 --> 01:25:42,000
+طيب الفصل الثاني اليوم
+
+896
+01:25:44,060 --> 01:25:49,700
+على موضوع برضه الـ Counselor اللي دخل فيه ويمكن من
+
+897
+01:25:49,700 --> 01:25:53,280
+أهم جوانب العملية في قضية الـ Genetic Diseases
+
+898
+01:25:53,280 --> 01:25:59,820
+أحيانًا في مواضيع اللي بيسموها أنه يكون «Prenatal
+
+899
+01:25:59,820 --> 01:26:03,460
+Diagnosis and Screening» يعني هي شو نعمل في
+
+900
+01:26:03,460 --> 01:26:07,380
+الأمراض الوراثية في المجتمع وكيف نقاومها وكيف
+
+901
+01:26:07,380 --> 01:26:08,360
+نتعامل معاها
+
+902
+01:26:11,320 --> 01:26:15,860
+الأمثلة على الأشياء هذه أنا بقول خلّينا نحطها
+
+903
+01:26:15,860 --> 01:26:22,120
+بثلاث جوانب في النقطة
+
+904
+01:26:22,120 --> 01:26:26,660
+الأولى، خلّينا قبل ما نبدأ من الأشياء المهمة
+
+905
+01:26:26,660 --> 01:26:31,860
+للتعامل مع الأمراض الوراثية أول شيء الـPremarital
+
+906
+01:26:31,860 --> 01:26:37,000
+diagnosis وScreening يعني اللي هو فحص الطبي قبل
+
+907
+01:26:37,000 --> 01:26:44,490
+الزواج، ماشي؟أحيانًا كثيرًا يعني إحنا بالقانون في
+
+908
+01:26:44,490 --> 01:26:48,810
+الأردن مأذون هو أتوقع كمان إن شاء الله في غزة
+
+909
+01:26:48,810 --> 01:26:54,710
+بيكونوا بيطبقوا نفس الأشياء أو أشياء زيها قضية إنه
+
+910
+01:26:54,710 --> 01:26:58,350
+مثلًا اللي بدهم يتزوجوا لازم يروح على مختبر طب
+
+911
+01:26:58,350 --> 01:27:03,430
+ويعملوا CBC وتشوف الواحد عشان مرض أنيميا البحر
+
+912
+01:27:03,430 --> 01:27:08,900
+الأبيض المتوسطاللي هو الـ Thalassemia ماشي حتى
+
+913
+01:27:08,900 --> 01:27:12,400
+نشخصهم بنروح بنقولهم روحوا يعملوا فحص الزواج قبل
+
+914
+01:27:12,400 --> 01:27:17,460
+الزواج وبندور على Microcytosis اللي هي مثال يعني
+
+915
+01:27:17,460 --> 01:27:22,940
+دليل على في الغالب على الـ Microcytic اللي هو يعني
+
+916
+01:27:22,940 --> 01:27:28,640
+career state للـ Thalassemiaوإذا إثنين هم، إذا
+
+917
+01:27:28,640 --> 01:27:32,980
+واحد بس اللي عنده الحالة نقولهم الله يسهل عليكم
+
+918
+01:27:32,980 --> 01:27:37,540
+اتجوزوا وكملوا الله يرزقهم ويفتح عليكم أما إن إذا
+
+919
+01:27:37,540 --> 01:27:43,000
+إثنين حاملين وإثنين عندهم ال possibility فهنا
+
+920
+01:27:43,000 --> 01:27:46,780
+بتصير الاحتمالية إنه ندخل في مشاكل ويكون الطفل
+
+921
+01:27:46,780 --> 01:27:52,180
+عنده تلسيميا وهذا غلب عليه وعلى أهله وعلى مجتمعه
+
+922
+01:27:52,180 --> 01:27:56,200
+وعلى كذايعني الـ Thalassemia Child، It's a long
+
+923
+01:27:56,200 --> 01:28:01,200
+life disease وما بيكونش حياتهم طبيعية وصحية
+
+924
+01:28:01,200 --> 01:28:06,120
+وبتغلبوا ومرضانين وبياخدوا نقل دم وبيدخلوا بـ
+
+925
+01:28:06,120 --> 01:28:12,820
+Heart Failure يعني بتعذّب هو وأهله فممكن واحد يقول
+
+926
+01:28:12,820 --> 01:28:21,710
+إن أنا أسوي إشي يعني ما قبل الزواج حتىهذا وارد
+
+927
+01:28:21,710 --> 01:28:25,890
+وممكن إنه مثلا إذا في عائلة أو في مجتمع في عندهم
+
+928
+01:28:25,890 --> 01:28:32,750
+احتمالية مرض معين ممكن أنا أدور على إنه يكون تطابق
+
+929
+01:28:32,750 --> 01:28:38,090
+الشخصين بشكل يمنع هذا المرض الموضوع الثاني حكينا
+
+930
+01:28:38,090 --> 01:28:45,430
+برضه عن جانب منه اللي هو قضية اللي هو موضوع عند
+
+931
+01:28:45,430 --> 01:28:51,770
+الولادةمن أول ما يولد بسوي Screening فيه يعني حتى
+
+932
+01:28:51,770 --> 01:28:56,450
+الآن حتى في دول متقدمة إحنا أنا حكينا الأردن مثلا
+
+933
+01:28:56,450 --> 01:29:01,670
+بنعمل على ثلاث أشياء بـVery Simple Test وطجة واحدة
+
+934
+01:29:01,670 --> 01:29:06,030
+وشغلتها بسيطة في المختبر بس بيعملوها لكل الأطفال
+
+935
+01:29:06,350 --> 01:29:12,250
+اللي هم الـ Creditism أو الـ Hypothyroidism نفحص
+
+936
+01:29:12,250 --> 01:29:17,550
+الـ TSH بدم الجنين وبالتالي بنقدر نعرف إذا عنده
+
+937
+01:29:17,550 --> 01:29:22,650
+نعطيها الـ Thyroxine شغل Simple، Easy، من تنقضه من
+
+938
+01:29:22,650 --> 01:29:29,610
+مرض سيء جداً، ماشي؟ الـ Thyroid Disease الـ PQ،
+
+939
+01:29:29,610 --> 01:29:35,050
+برضه بنعمله، دخلناها، والفكرة فيه إنه إذا أكل لوغ
+
+940
+01:29:37,370 --> 01:29:42,090
+بالفنال الألاذين بالذات كـ Mino Acid بيكون الطفل
+
+941
+01:29:42,090 --> 01:29:45,190
+طبيعي ماعنده أي مشكلة بالنسبة لـ Mental
+
+942
+01:29:45,190 --> 01:29:49,430
+retardation ولا أي شيء ثاني فهي بنعملها وحكاية الـ
+
+943
+01:29:49,430 --> 01:29:54,170
+HIV برضه بيعملوه من باب الـ Screening في دول تانية
+
+944
+01:29:54,170 --> 01:29:58,270
+مثلا بيعملوا Screening على الـ بعد الولادة على كل
+
+945
+01:29:58,270 --> 01:30:03,930
+الـ Immune Deficiencies فبرضه يعني عندهم إنكانات
+
+946
+01:30:03,930 --> 01:30:10,600
+وعندهميعني طرق أنه كمختبر نفحص لكل الموليد الجدد
+
+947
+01:30:10,600 --> 01:30:14,860
+ونسوي الـ Screening ضمن بقية الـ Screening للأشياء
+
+948
+01:30:14,860 --> 01:30:20,140
+التانية النقطة اللي راح نتكلم عنها في الفصل هذا هي
+
+949
+01:30:20,140 --> 01:30:27,800
+جوانب نفحص على الجنين هو لسه بطن أمه والأمر يعني
+
+950
+01:30:27,800 --> 01:30:34,760
+سواء كأخلاقيراح نتكلم عن جوانب الأخلاقية في محاضرة
+
+951
+01:30:34,760 --> 01:30:43,160
+قادمة موضوع كيف، شو نعمل بالنسبة إذا شخصنا إشي
+
+952
+01:30:43,160 --> 01:30:48,320
+يعني في ثقافات، وحكينا إحنا مضطرين الاحترام
+
+953
+01:30:48,320 --> 01:30:54,400
+للثقافات المختلفة القوانين المختلفة، الأديان
+
+954
+01:30:54,400 --> 01:31:01,960
+المختلفةالأديان، الأديان يعني الإسلام ويعني مثلًا
+
+955
+01:31:01,960 --> 01:31:07,220
+بين أخواننا المسيحيين الكاتوليك مثلًا الإجهاض حرام
+
+956
+01:31:07,220 --> 01:31:12,580
+أحنا في الإسلام ومثلًا الكاتوليكيين الإجهاض فقط
+
+957
+01:31:12,580 --> 01:31:18,760
+حلال لإنقاذ حياة الأمة يعني للمحافظة على الأصل أنت
+
+958
+01:31:18,760 --> 01:31:25,120
+تضحي بالفرع هيك يعني بأرضه على أساس أنه الجنين فرع
+
+959
+01:31:25,120 --> 01:31:30,740
+من أمهوإنه يعني بندخل في موضوع حتى بالنسبة كإجهاد
+
+960
+01:31:30,740 --> 01:31:35,160
+في الإسلام في قضية متى نفخ الروح اللي هو إنسان
+
+961
+01:31:35,160 --> 01:31:40,240
+منفصل أو مش منفصل وندخل في الموضوع هذا بس في أشياء
+
+962
+01:31:40,240 --> 01:31:46,560
+نقدر نسويها وخصوصًا إذا ثقافة ولا مجتمع يعني في
+
+963
+01:31:46,560 --> 01:31:51,240
+الدول الغربية في تفاوت في أمريكا مثلًا على قضية
+
+964
+01:31:51,240 --> 01:31:57,820
+الإجهادالنساء بتقولّك، ها الحمل طالما هو لسه بطني
+
+965
+01:31:57,820 --> 01:32:01,840
+هو جزء مني وانا مسئول عنه وانا اللي بتحمل وانا
+
+966
+01:32:01,840 --> 01:32:07,660
+اللي بسوي وبالتالي يعني حتى لو بالشهر التاسع وبدها
+
+967
+01:32:07,660 --> 01:32:15,260
+تعمل إجهاد يعني هذا كتلة دم ولحم ومالوش قيمة وانا
+
+968
+01:32:15,260 --> 01:32:21,630
+خلصت من ورم وخلاصماشي، فالإجهاد يعني هو في كل
+
+969
+01:32:21,630 --> 01:32:28,150
+المستنكر بعد التأخير يعني أصل إذا بدأت قررت إجهاد
+
+970
+01:32:28,150 --> 01:32:33,250
+الأول تعمله بفترة مبكرة يعني قبل ما يتخلق ولا يبين
+
+971
+01:32:33,250 --> 01:32:39,430
+إنه إنسان أو قريب من الإنسان بس بيظل إنه يعني في
+
+972
+01:32:39,430 --> 01:32:46,100
+أطباء وفي كذا إنه إذاالتي أثبتت إن الطفل عنده خلل
+
+973
+01:32:46,100 --> 01:32:52,340
+وراثي معين أو مرض معين سيء وعامل مشكلة إن أنا ممكن
+
+974
+01:32:52,340 --> 01:32:58,000
+أعمل إجهاض وأخلص منه فبيهمني إن أنا أشخص طبعاً
+
+975
+01:32:58,000 --> 01:33:01,820
+واحد بدخل في جوانب أخلاقي بيضل يدخل فيها خضية إنه
+
+976
+01:33:01,820 --> 01:33:06,540
+طب شو عرفك يعني لو إنسان عنده مرض منغولية Down
+
+977
+01:33:06,540 --> 01:33:12,720
+Syndrome يعني أنت هيك من برا بتقول هوالمعذب هو
+
+978
+01:33:12,720 --> 01:33:20,380
+بعذب، هو مريض يعني تقريبًا زي ما النازيين في
+
+979
+01:33:20,380 --> 01:33:25,260
+ألمانيا قرروا أنه يعني خلصوهم من معاناتهم وقتلوهم
+
+980
+01:33:25,260 --> 01:33:30,580
+كلهم ويعني يتبحوا أي واحد عنده مثل هذا الأشياء
+
+981
+01:33:30,580 --> 01:33:35,720
+وكذلك يعني قضية أنه في فترة الحمل ممكن أحيانًا
+
+982
+01:33:35,720 --> 01:33:43,540
+يكون عندنايعني آليات للتعامل ممكن إجهاد، ممكن
+
+983
+01:33:43,540 --> 01:33:49,660
+مثلًا الطفل جنين وعنده congenital heart disease
+
+984
+01:33:49,660 --> 01:33:56,480
+وعنده ما هو اسمه؟ اللي ممكن يجروله عملية وهو لسه
+
+985
+01:33:56,480 --> 01:34:01,370
+جنينفي بعض المرات مثلًا «هيدروبس فيتاليس» وصار
+
+986
+01:34:01,370 --> 01:34:08,670
+عنده تكسر دم بنقوله «للجنين في بطن أمه دم» يعني
+
+987
+01:34:08,670 --> 01:34:14,290
+مرات بتكون فيه خيارات ممكن أعملها حسب الحالة وحسب
+
+988
+01:34:14,290 --> 01:34:18,310
+الـ «حسب
+
+989
+01:34:18,310 --> 01:34:22,350
+الوضع» يعني طبعًا مع العائلة، «شو صار معاهم؟» «إيش
+
+990
+01:34:22,350 --> 01:34:30,980
+نحن بنتكلم؟» والفكرة أنه أنالما أقول بعمل تفتيش
+
+991
+01:34:30,980 --> 01:34:38,540
+على شيء معين بقول بعمله Screening من الأشياء اللي
+
+992
+01:34:38,540 --> 01:34:44,460
+مثلا يعني كويسة وممكن أحياناً أعملها أحنا راح نحكي
+
+993
+01:34:44,460 --> 01:34:47,960
+على شو الأشياء اللي ممكن أعملها خلينا بعد شوية
+
+994
+01:34:47,960 --> 01:34:55,810
+بنرجع للـSlide اللي قبلالـ Slide هذا اللي هو رقم
+
+995
+01:34:55,810 --> 01:35:04,950
+17-1 Figure 17-1 بيحكينا عن ثلاث أنواع من أنواع
+
+996
+01:35:04,950 --> 01:35:10,350
+الفحوصات اللي أستخدمها كـ Screening عند الحمل عشان
+
+997
+01:35:10,350 --> 01:35:15,490
+أشوف الطفل مصاب أو غير مصاب أو الجنين مصاب أو غير
+
+998
+01:35:15,490 --> 01:35:22,270
+مصاب الجنين، اللي لسه هو مرحلة الجنين الـ Aاللي هو
+
+999
+01:35:22,270 --> 01:35:29,470
+مسمّينه «amniotic fluid sampling» ماشي، الـ
+
+1000
+01:35:29,470 --> 01:35:33,710
+«amniocentesis»
+
+1001
+01:35:33,710 --> 01:35:38,550
+هيك يسميه الـ «parietal synthesis» أو كده اللي هي
+
+1002
+01:35:38,550 --> 01:35:45,810
+يعني البذل أو اللي صاحب العينة فالمثال الأول A إنه
+
+1003
+01:35:45,810 --> 01:35:54,220
+أنا باجي بالـ «Ultrasound» Guidedبدخل نيدل في بطن
+
+1004
+01:35:54,220 --> 01:36:01,360
+الأم، ببعد عن الجنين، ببعد عن المشيمة، ببعد عن أي
+
+1005
+01:36:01,360 --> 01:36:07,320
+إشي بيخوف، وبدخل النيدل في الـFluid المحيط
+
+1006
+01:36:07,320 --> 01:36:12,440
+بالجنين، وباخد منه خلايا، باخد منه Fluid، في
+
+1007
+01:36:12,440 --> 01:36:19,290
+الغالب Fluid، بكون بقدر أفحصه للأشياء هذه مثلًا،زي
+
+1008
+01:36:19,290 --> 01:36:22,830
+الـ Chemical نتال زي الـ Alpha-Fetoprotein راح
+
+1009
+01:36:22,830 --> 01:36:28,250
+نحكي عنه الـ Chromosome الـ الـ Components الـ
+
+1010
+01:36:28,250 --> 01:36:31,930
+Chromosome الـ Enzyme Parameters و الـ DNA
+
+1011
+01:36:31,930 --> 01:36:38,490
+Analysis ممكن أبعثها لأشياء كثيرة هنا الـ يعني هذه
+
+1012
+01:36:38,490 --> 01:36:45,130
+مشتركة و جزء منها ممكن يعني هو في الغالب من الـ
+
+1013
+01:36:46,770 --> 01:36:51,450
+الجنين نفسه، بس إيه له ارتباط بالأم وفيه ارتباط
+
+1014
+01:36:51,450 --> 01:36:56,270
+يعني ممكن الـFluid هذا أقدر أفحص فيه أشياء وفي
+
+1015
+01:36:56,270 --> 01:37:01,270
+أحيان مابقدرش أفحص فيه أشياء تانية يعني حسب شو
+
+1016
+01:37:01,270 --> 01:37:07,230
+المشكلة، وأنا كيف أفحص هل هذا الـSample مناسب لهذا
+
+1017
+01:37:07,230 --> 01:37:12,650
+الفحص ولا لأ؟ الطريقة الثانية، اللي هي Quranic
+
+1018
+01:37:12,650 --> 01:37:20,610
+Villai Samplingهنا أنا بدي أخد من الـ villas تبع
+
+1019
+01:37:20,610 --> 01:37:25,990
+الكوريون اللي هي برضه من الجنين بس أنا باخد cells
+
+1020
+01:37:25,990 --> 01:37:35,330
+أكثر، cells يعني أنا متأكد إنها من الجنين وبتكون
+
+1021
+01:37:35,330 --> 01:37:41,630
+أحسن إن أفحص عليها زي كروموزومات، زي جينات، زي
+
+1022
+01:37:41,630 --> 01:37:47,140
+أشياءفالـ الـ الـ الـ هنا العيب أو الملاحظ أن أنا
+
+1023
+01:37:47,140 --> 01:37:51,800
+بدي أضطر أخد من الماشيمة نفسها فأنا بدي أخذق
+
+1024
+01:37:51,800 --> 01:37:55,940
+الماشيمة يعني الماشيمة ممكن تنزف ممكن يكون فيها
+
+1025
+01:37:55,940 --> 01:38:02,180
+مشكلة ممكن أنا أخرّب في الحالة هذه فهذا موضوع أعقد
+
+1026
+01:38:02,180 --> 01:38:08,100
+فهنا زي ما أنتم شايفين الـ Sonar حاطينه من فوقوالـ
+
+1027
+01:38:08,100 --> 01:38:17,160
+«حاطين» بحطه يعني «سيرنج» أو Wire، «كانيولا» عشان
+
+1028
+01:38:17,160 --> 01:38:22,140
+أنا أدخل لجوا أكثر وبعدين باخد الـ «سامبل» حيث أنا
+
+1029
+01:38:22,140 --> 01:38:26,840
+أكون متأكد إن أنا واصل مش بس بالـ «سونار» عمياني
+
+1030
+01:38:26,840 --> 01:38:30,840
+هيك على الـ«أمانيوسنتيسيس»
+
+1031
+01:38:30,840 --> 01:38:34,340
+لأ، أنا هنا بدأ أصل لهذه المكان، للـ«بلاسنتا»،
+
+1032
+01:38:34,340 --> 01:38:41,800
+للمشيمة، وبدأ أخد عينة منهاهذا أسلوب ثاني أحصل
+
+1033
+01:38:41,800 --> 01:38:48,860
+Sample من الجنين عشان أقدر أعمل دراسات معينة
+
+1034
+01:38:48,860 --> 01:38:56,080
+الموضوع الثالث اللي هو مربوط بإنه أنا الأيام هذه
+
+1035
+01:38:56,080 --> 01:38:58,560
+تعرفوا كلكم اللي هو موضوع الـ In Vitro
+
+1036
+01:38:58,560 --> 01:39:05,260
+Fertilization التلقيح خارج الجسم خارج الرحم أو في
+
+1037
+01:39:05,260 --> 01:39:11,520
+المختبرالتلقيح هذا بدأ من خلال النساء اللي عندهم
+
+1038
+01:39:11,520 --> 01:39:15,800
+مثلًا تسكير في القنوات Fallopian tubes أو أنابيبي
+
+1039
+01:39:15,800 --> 01:39:20,940
+مسكرة فعندها الـ الـ عندها الـ egg طبيعي والرحم
+
+1040
+01:39:20,940 --> 01:39:27,120
+طبيعي من تاني والمبايظ كويسة والزلمة كويس بس الـ
+
+1041
+01:39:27,120 --> 01:39:32,620
+Spare ما بقدر يصل لل egg فبناخد الـ egg برا وبن ..
+
+1042
+01:39:32,620 --> 01:39:37,360
+شو اسمه؟بنعرضها للـSperms وبصير الـFertilization
+
+1043
+01:39:37,360 --> 01:39:44,100
+وانا في المختبر يعني عادةً هذه الشغل بالـIn vitro
+
+1044
+01:39:44,100 --> 01:39:50,260
+fertilization اللي لما يكون عندهم في الـPetri dish
+
+1045
+01:39:50,260 --> 01:39:55,180
+أو في الـCell culture medium بيقدر الواحد تحت
+
+1046
+01:39:55,180 --> 01:39:58,900
+الماكروسكوب يشوف تطور البني آدم تبدأ خلية واحدة
+
+1047
+01:39:58,900 --> 01:40:03,520
+تنقسم خليتين، أربعة، تمانية، ستاشربصير doubling،
+
+1048
+01:40:03,520 --> 01:40:07,700
+doubling، doubling كل يوم وبصير يعني متوقع مثلًا
+
+1049
+01:40:07,700 --> 01:40:14,740
+ولهن أسماء لـPlastomere مثلًا بستنوا لما تصير
+
+1050
+01:40:14,740 --> 01:40:19,100
+الخلايا ثمان خلايا يعني بيكون في مرحلة معينة وهذا
+
+1051
+01:40:19,100 --> 01:40:26,140
+كله لسه قبل ما نرجع الطفل أو الجنين للرحم في الأم
+
+1052
+01:40:26,140 --> 01:40:33,090
+أن أخذ خلية من هذه الخلايا، ماشي؟أحيانًا بعد ما
+
+1053
+01:40:33,090 --> 01:40:36,030
+يصير الـ Implantation أو إذا هذه بتصير يعني
+
+1054
+01:40:36,030 --> 01:40:40,590
+بيستنوا عليها أكثر جوا الـ Test tube لأنه بتصير
+
+1055
+01:40:40,590 --> 01:40:45,150
+على شكل كرة وهذه هي اللي بيصير الـ Implantation في
+
+1056
+01:40:45,150 --> 01:40:54,630
+الرحم ممكن أني أخذ يعني هنا أحنا حكينا أخذ عينة
+
+1057
+01:40:54,630 --> 01:41:01,990
+بهذه الطريقة من هذه المرحلة أو أستنى أكثر وأخذيعني
+
+1058
+01:41:01,990 --> 01:41:05,410
+هذه المنطقة الكتلة هذه هي اللي راح تكون الجنين
+
+1059
+01:41:05,410 --> 01:41:10,190
+ماشي الـ Inner Cell Mass هي اللي راح تكون الجنين
+
+1060
+01:41:10,190 --> 01:41:13,770
+بهجي على منطقة بعيد عنها وبكون تحت الـ Microscope
+
+1061
+01:41:13,770 --> 01:41:18,250
+أنا بشوف أي خلية باخد وبعدين بوديها على المختبر
+
+1062
+01:41:18,250 --> 01:41:23,410
+بدور على أي شيء اللي بديهافيعني هدولة الثلاث
+
+1063
+01:41:23,410 --> 01:41:27,830
+خيارات الأمانيوسينتيسيس
+
+1064
+01:41:27,830 --> 01:41:33,110
+الـ Villas Sample «فوريونيك فيلاي» Sampling
+
+1065
+01:41:33,110 --> 01:41:33,970
+«فوريونيك فيلاي» Sampling «فوريونيك فيلاي»
+
+1066
+01:41:33,970 --> 01:41:35,030
+Sampling «فوريونيك فيلاي» Sampling «فوريونيك
+
+1067
+01:41:35,030 --> 01:41:36,090
+فيلاي» Sampling «فوريونيك فيلاي» Sampling
+
+1068
+01:41:36,090 --> 01:41:39,650
+«فوريونيك فيلاي» Sampling «فوريونيك فيلاي»
+
+1069
+01:41:39,650 --> 01:41:39,650
+Sampling «فوريونيك فيلاي» Sampling «فوريونيك
+
+1070
+01:41:39,650 --> 01:41:39,650
+فيلاي» Sampling «فوريونيك فيلاي» Sampling
+
+1071
+01:41:39,650 --> 01:41:39,730
+«فوريونيك فيلاي» Sampling «فوريونيك فيلاي»
+
+1072
+01:41:39,730 --> 01:41:42,950
+Sampling «فوريونيك
+
+1073
+01:41:42,950 --> 01:41:50,430
+فيلاي» Sampling «فوريونيك فيلا
+
+1074
+01:41:51,510 --> 01:41:59,210
+وعبارة عن يعني حتى الواحد يتخذ قرار بيكون منتبه
+
+1075
+01:41:59,210 --> 01:42:07,210
+لكل الاحتمالات وكل النقاط مثلا،
+
+1076
+01:42:07,210 --> 01:42:11,790
+من الأشياء اللي تعمل الـ Alpha-Fetoprotein الـ
+
+1077
+01:42:11,790 --> 01:42:14,930
+Alpha-Fetoprotein يعني انتوا يمكن عندكم معلومة عنه
+
+1078
+01:42:14,930 --> 01:42:21,320
+هو من الـ يعني بنعتبرهم tumor antigensالـ Alpha
+
+1079
+01:42:21,320 --> 01:42:26,140
+-Fetoprotein عندنا في الـ Adult يعني في الناس
+
+1080
+01:42:26,140 --> 01:42:31,060
+العاديين بعدين في بعض أنواع السرطانات سواء liver
+
+1081
+01:42:31,060 --> 01:42:35,260
+cancer، GI cancer يخلّي هذا البروتين يعلق
+
+1082
+01:42:35,260 --> 01:42:42,000
+والبروتين هذا بعلق هو في الأصل عبارة عن بديل
+
+1083
+01:42:42,000 --> 01:42:46,410
+الألبومينبكون موجود خلال الـ embryonic period
+
+1084
+01:42:46,410 --> 01:42:51,010
+ويكون وظيفته يخل السوائل جوا الدور الدمائي، ما
+
+1085
+01:42:51,010 --> 01:42:56,590
+يخلّيها تطلع فالـ Alpha-Fetoprotein هذا موجود وفي
+
+1086
+01:42:56,590 --> 01:43:02,310
+الحملة الطبيعية، في المرحلة الجنينية، بكون طبيعي
+
+1087
+01:43:02,310 --> 01:43:11,740
+أن يكون موجودماشي، فلما نكون يعني من الأشياء
+
+1088
+01:43:11,740 --> 01:43:17,500
+الثانية اللي بتسببه زيادة في الحمل الـ Neural Tube
+
+1089
+01:43:17,500 --> 01:43:22,040
+Defects اللي هي Spinal بفدة أو Unencephaly أو
+
+1090
+01:43:22,040 --> 01:43:26,350
+مشاكل طبعاً هذه جزء منهبالـ Embryology لازم تكونوا
+
+1091
+01:43:26,350 --> 01:43:30,410
+أخدتوا كيف إنسان بتشكل و الـ neural tube بتلم
+
+1092
+01:43:30,410 --> 01:43:34,110
+وبتضم بعد ما هيك وتصير two ridges بيصير زي الخندق
+
+1093
+01:43:34,110 --> 01:43:37,890
+وبعدين ال tube بتكون وبعدين بيلف على بعضه وبتكون
+
+1094
+01:43:37,890 --> 01:43:42,810
+الدماغ وبتكون باقية الأشياء فإذا في عندنا anomaly
+
+1095
+01:43:42,810 --> 01:43:52,990
+بالـ neuronal tubeماشي، بيصير عندى، شو اسمه؟ الـ
+
+1096
+01:43:52,990 --> 01:43:57,550
+Alpha-Fetoprotein بيصير إفرازه بتصير مستوى أعلى
+
+1097
+01:43:57,550 --> 01:44:06,050
+فإذا أخدت Ammoniac Fluid Alpha-Fetoprotein كمؤشر
+
+1098
+01:44:06,050 --> 01:44:11,750
+على وجود Neuronal Tube Defect ويعني عيلة خايفين من
+
+1099
+01:44:11,750 --> 01:44:17,220
+هذا الموضوع عندهم طفل كان أنانكفلياللي هو من فوق،
+
+1100
+01:44:17,220 --> 01:44:21,420
+يعني مالوش دماغ من فوق أو من تحت إشي بيسموه Spinal
+
+1101
+01:44:21,420 --> 01:44:26,580
+Bifida و لا كده فبيجي واحد بيقول خلّينا نسحب شوية
+
+1102
+01:44:26,580 --> 01:44:30,780
+Fluid و هذا الفحص بسيط وسهل مغلبش للـ Alpha
+
+1103
+01:44:30,780 --> 01:44:39,920
+-Fetoprotein بعمله وبعدين بقرر عليه فالفكرة كمان
+
+1104
+01:44:39,920 --> 01:44:44,860
+إنه الـ Alpha-Fetoprotein لما نيجي نقرر كدهش الـ
+
+1105
+01:44:44,860 --> 01:44:49,780
+Normal Levelجزء من الموضوع أنه الواحد يكون عارف
+
+1106
+01:44:49,780 --> 01:44:55,000
+كام شهر الأنثى هذه أو الأم هذه الحامل صار حاملها
+
+1107
+01:44:55,000 --> 01:44:58,580
+هذا فلمّا
+
+1108
+01:44:58,580 --> 01:45:03,560
+يكون الـ Alpha-Fetoprotein يعني في adult وإنسان
+
+1109
+01:45:03,560 --> 01:45:06,800
+بعد الولادة ومنذ الكبيرة وصار الـ Alpha
+
+1110
+01:45:06,800 --> 01:45:09,340
+-Fetoprotein عالي بقول يمكن هذا liver cancer،
+
+1111
+01:45:09,340 --> 01:45:13,580
+colon cancer مش عارف إيش عنده، ففي الـFetal period
+
+1112
+01:45:14,340 --> 01:45:18,100
+يمكن الـ Fetal Blood Contamination حكينا إنه أنا
+
+1113
+01:45:18,100 --> 01:45:23,860
+المفروض أخد من الـ Ammoniac Fluid أفرض إن أنا جرحت
+
+1114
+01:45:23,860 --> 01:45:30,700
+الطفل وصار عنده نوع من النزف فنتيجة الأمر هذا راح
+
+1115
+01:45:30,700 --> 01:45:34,580
+يكون عندي الـ Alpha-Fetoprotein عالي Fetal Death
+
+1116
+01:45:34,580 --> 01:45:41,870
+إذا كان فيه Still Birth أو وفاة الحمل نفسهفي حالة
+
+1117
+01:45:41,870 --> 01:45:46,810
+الـ Twin Pregnancies إذا أنا مش منتبه وكان فيه
+
+1118
+01:45:46,810 --> 01:45:53,610
+حملة توقم وبالتالي كمية الحمل أكبر وبالتالي الـ
+
+1119
+01:45:53,610 --> 01:45:57,730
+Alpha-Fetoprotein ممكن يكون مستوقع أعلى Fetal
+
+1120
+01:45:57,730 --> 01:46:01,570
+Anomalies مثل هذه الأنواع برضه بترفعوا
+
+1121
+01:46:03,930 --> 01:46:08,910
+في أشياء دائما ممكن تكون مجهولة أو الـ
+
+1122
+01:46:08,910 --> 01:46:15,090
+«overestimation of gestational age» يعني شكله
+
+1123
+01:46:15,090 --> 01:46:22,070
+كل ما … يعني هنا إذا بنعتبره مرتفع فكان لأنه احنا
+
+1124
+01:46:22,070 --> 01:46:27,440
+هي مثلا أنا فكرت حامل بالشهر الثالثوهو أنا المفروض
+
+1125
+01:46:27,440 --> 01:46:32,740
+يكون بدأ ينزل الـ Alpha-Fetoprotein وانا بفكرها هي
+
+1126
+01:46:32,740 --> 01:46:38,960
+بالشهر مثلا السادس فهي حقيقة بالثالث وبعدها بكون
+
+1127
+01:46:38,960 --> 01:46:45,000
+أعلى طبيعي فممكن يكون بأنه أنا في كان خطأ في تقدير
+
+1128
+01:46:45,000 --> 01:46:52,720
+الحمل لما أخدناها وبالتالي يعني دائما صحيح أننا
+
+1129
+01:46:52,720 --> 01:46:56,480
+سوينا الـ procedureوعلى ضوءه، سأقول إن هذا مرتفع
+
+1130
+01:46:56,480 --> 01:47:00,220
+والله، يمكن الـ Neuronal Tube Defect «خلّيني أخلص
+
+1131
+01:47:00,220 --> 01:47:04,020
+منه» «ما بديش الحمل لأنه راح يغلب ويغلب وعنده
+
+1132
+01:47:04,020 --> 01:47:09,420
+المرض» وممكن يطلع إن هذا القراءة هي الغلط، مش أن
+
+1133
+01:47:09,420 --> 01:47:15,680
+الحالة فيها غلط فلما
+
+1134
+01:47:15,680 --> 01:47:20,340
+نعمل هنا، يعني النقطة التانية اللي بنتكلم عنهااللي
+
+1135
+01:47:20,340 --> 01:47:26,080
+هي أنه لما أخد من الـPlacenta أو الـCorionic villi
+
+1136
+01:47:26,080 --> 01:47:30,320
+Sampling باخد بيقوسين الـTertiary Corionic villi
+
+1137
+01:47:30,320 --> 01:47:37,600
+يعني بدي أخد جانب معين يعني اللي هنا هي الكيس
+
+1138
+01:47:37,600 --> 01:47:43,580
+الحمل هنا الجنين
+
+1139
+01:47:43,580 --> 01:47:51,660
+نفسه والطبقات تبعتهوبعدين هنا زي اللي بدّي أعمل
+
+1140
+01:47:51,660 --> 01:47:55,480
+الـPlacenta أو بدّي أعمل كده فبدأ أروح على مكان
+
+1141
+01:47:55,480 --> 01:48:00,640
+محدد عشان أاخد منه الـConnective tissues اللي
+
+1142
+01:48:00,640 --> 01:48:05,220
+بيفيها الـCells تبع الجنين والـBlood vessels وأعمل
+
+1143
+01:48:05,220 --> 01:48:16,460
+الفحص عليه بظل أنه لما يكون في عندنا Machine فيه
+
+1144
+01:48:16,460 --> 01:48:23,760
+Interactionبين الأم والجنين يعني دايماً في الولادة
+
+1145
+01:48:23,760 --> 01:48:27,920
+وخلال الحمل بيصير اختلاط بين خلايا الأم وبين خلايا
+
+1146
+01:48:27,920 --> 01:48:28,720
+الجنين
+
+1147
+01:48:31,480 --> 01:48:38,440
+حوالين الجنين، فيه الـ Cytotrophoplast وCyno نوع
+
+1148
+01:48:38,440 --> 01:48:42,080
+ثاني من الـ Trophoplast وفيه الـ Maternal blood و
+
+1149
+01:48:42,080 --> 01:48:46,360
+Maternal Sinusoid وفيه الـ Veins و الـ Capillaries
+
+1150
+01:48:46,360 --> 01:48:50,640
+و الـ Arteries تبع الجنين نفسه فكل دولة بيشتركوا
+
+1151
+01:48:50,640 --> 01:48:55,780
+مع بعض حتى ي support the patient أو ي support
+
+1152
+01:48:55,780 --> 01:49:00,320
+الجنين في الحالة
+
+1153
+01:49:00,320 --> 01:49:00,580
+هذه
+
+1154
+01:49:03,870 --> 01:49:08,090
+من الأشياء اللي بنقدر نعملها، فأحنا حكينا ممكن
+
+1155
+01:49:08,090 --> 01:49:12,770
+Ammoniotic Fluid Sampling ممكن Villus Sampling
+
+1156
+01:49:12,770 --> 01:49:19,190
+لأشياء أخرى ممكن في الـ «إن فيترو» أخد يعني سامبل
+
+1157
+01:49:19,190 --> 01:49:23,850
+من الـ«بلاستومير»
+
+1158
+01:49:23,850 --> 01:49:27,770
+قبل حتى من الأشياء المفيدة وكمان ممكن واحد يدور
+
+1159
+01:49:27,770 --> 01:49:31,730
+على أشياء معينة إذا كان واحد عنده خبرةاللي هو الـ
+
+1160
+01:49:31,730 --> 01:49:35,090
+Ultrasonography الـ Prenatal Diagnostic
+
+1161
+01:49:35,090 --> 01:49:39,810
+Ultrasonography الـ Sonar يعني عادةً بتعرفوا
+
+1162
+01:49:39,810 --> 01:49:43,730
+بيدوروا عادةً على الـ Heartbeat يشوف الـ إذا ذكروا
+
+1163
+01:49:43,730 --> 01:49:49,430
+الأنثى يشوف الـ External Genitalia بالنسبة للجنين،
+
+1164
+01:49:49,430 --> 01:49:53,710
+أشياء معينة فدولة يعني اللي هم العادي، الـ Sonar
+
+1165
+01:49:53,710 --> 01:49:58,670
+العادي اللي عادة الأطباء النسائي بيعملوه يعني
+
+1166
+01:49:58,670 --> 01:50:05,600
+بيدوروا واحدة أشياء معينةفيه بالنسبة لـ الـ يعني
+
+1167
+01:50:05,600 --> 01:50:08,880
+الـ other types of diseases that also can be
+
+1168
+01:50:08,880 --> 01:50:11,860
+diagnosed بس بيكون اللي بيعمل الـ sonar يعني
+
+1169
+01:50:11,860 --> 01:50:17,140
+experienced وبعرف على إيش بيدور وعن إيش بيدور وشو
+
+1170
+01:50:17,140 --> 01:50:21,680
+اللي بيدور عليه ففيه مرات single gene disorders
+
+1171
+01:50:21,680 --> 01:50:25,860
+دول الأسماء تبعتهم ممكن بالـ sonar يعني الـ
+
+1172
+01:50:25,860 --> 01:50:29,040
+infantile polycystic kidney diseaseاللي هو الـ
+
+1173
+01:50:29,040 --> 01:50:32,380
+Polycystic Kidney Disease أنا عادة بشوفهم لـ Adult
+
+1174
+01:50:32,380 --> 01:50:36,000
+Polycystic Kidney Disease بيكون بيبين بعدين ففيه
+
+1175
+01:50:36,000 --> 01:50:40,200
+Severe Form وبيكون بدخله Renal Failure وكذا وكذا
+
+1176
+01:50:40,200 --> 01:50:45,220
+من الولادة وفي فترة سريعة كثير وبيكون فيه Multiple
+
+1177
+01:50:45,220 --> 01:50:50,200
+Cysts على الـ Kidneys بتنشف في الجنين خلال الـ
+
+1178
+01:50:50,200 --> 01:50:55,660
+Ultrasonography حتى في الحمل Disorders هدولة أمثلة
+
+1179
+01:50:55,660 --> 01:50:58,740
+على Single Gene Disordersفيه كبار الـ Disorders
+
+1180
+01:50:58,740 --> 01:51:03,800
+مثلًا «مرتفاكتوريال» الـ «Cliff-lip»، «Club-foot»،
+
+1181
+01:51:03,800 --> 01:51:06,220
+«Congenital Heart Disease»، «Neuronal Tube
+
+1182
+01:51:06,220 --> 01:51:12,080
+Defect»، حكينا عنهم، هدولة كلهم موجودة وفي مرات
+
+1183
+01:51:12,080 --> 01:51:16,680
+إذا في أشياء معينة، ممكن تخليني أشكك سندروم معين،
+
+1184
+01:51:16,680 --> 01:51:21,080
+الـ «Abnormal Genitalia»، «Cystic Hagroma»، اللي
+
+1185
+01:51:21,080 --> 01:51:25,040
+هو يعني نوع من الأولمع الوجهة ضنني، ويكون له شكل
+
+1186
+01:51:25,040 --> 01:51:29,930
+معين،عدد الأصابع الـ Polydectomy وSyndectomy دي
+
+1187
+01:51:29,930 --> 01:51:33,570
+الأصابع ملتصقة ببعض طبعاً بدي يكون على مستوى معين
+
+1188
+01:51:33,570 --> 01:51:37,730
+تطور الجنين الـ Ophthalmalocele هذا اللي على
+
+1189
+01:51:37,730 --> 01:51:43,330
+بالبطن بيصير أنه يعني defect معين الـ Radial Ray
+
+1190
+01:51:43,330 --> 01:51:53,520
+Defect أشياء معينة فالـ هنا يعني الـ Sonographyفي
+
+1191
+01:51:53,520 --> 01:51:59,600
+مرات بتخليني أكتشف أشياء كثيرة وبرضه ممكن تعمل
+
+1192
+01:51:59,600 --> 01:52:05,260
+فإحنا يعني على قول اللي بيسأله هذا مطلوب ولا مش
+
+1193
+01:52:05,260 --> 01:52:14,100
+مطلوب، كأرقام وقداش النسب وكده وكده، لأ، ما بديش،
+
+1194
+01:52:14,100 --> 01:52:19,700
+بس الفكرة إنه الـ Sonography ممكن simple، non
+
+1195
+01:52:19,700 --> 01:52:25,930
+-invasiveeasy to do بس بيدها experience بيدها واحد
+
+1196
+01:52:25,930 --> 01:52:31,670
+فاهمان حتى يستثنى الموضوع يعني من القصص المشهورة
+
+1197
+01:52:31,670 --> 01:52:37,630
+جداً مثلا ييجوا عائلة يقولوا والله جابت خمس بنات
+
+1198
+01:52:37,630 --> 01:52:41,610
+وهسا الحملة السادس وييجوا واحد تبع Sonar مال
+
+1199
+01:52:41,610 --> 01:52:46,670
+بيفهمش ييجوا شاف وقال له هذا Female ممكن تطلع
+
+1200
+01:52:46,670 --> 01:52:50,560
+بالأخير Male يعني ممكن يكونبيطلع عنده بيطلع ولد
+
+1201
+01:52:50,560 --> 01:52:55,540
+يعني بالعكس يعني ففي مرات مشاكل إنه درجة خبرة
+
+1202
+01:52:55,540 --> 01:53:00,960
+الإنسان اللي بيقوم يعني الـ «الترساون» is as good
+
+1203
+01:53:00,960 --> 01:53:07,340
+as الـ person doing it حاطين بالكتاب بصراحة ما
+
+1204
+01:53:07,340 --> 01:53:11,460
+جبتهمش لإن أنا مش عارف أشرح عليهم بفهمش فيهم ومش
+
+1205
+01:53:11,460 --> 01:53:17,080
+تخصصي ومش خبير فيهم حاطين صور اللي هي أمثلة على
+
+1206
+01:53:17,080 --> 01:53:21,180
+الحالات هذهوكيف إنها بتبين بالـ Ultrasound وممكن
+
+1207
+01:53:21,180 --> 01:53:32,100
+شخصه من خلالها ففي عندنا قضية إنه كل ما بشوف مشاكل
+
+1208
+01:53:32,100 --> 01:53:38,160
+أكثر في الـ Ultrasound معناته الـ Abnormal
+
+1209
+01:53:38,160 --> 01:53:42,570
+Karyotype أو إن المشكلة أعقدالـ Karyotype نتذكر من
+
+1210
+01:53:42,570 --> 01:53:47,270
+الـ previous lectures لما نتكلم على huge area سواء
+
+1211
+01:53:47,270 --> 01:53:52,190
+chromosomal defect هذه بقدر أقصيدها بالـ Karyotype
+
+1212
+01:53:52,190 --> 01:53:57,470
+أو large chromosome segment سواء deletion،
+
+1213
+01:53:57,470 --> 01:54:02,870
+translocation، الـ other things فإيش يكون بالـ
+
+1214
+01:54:02,870 --> 01:54:08,320
+Abnormal Karyotype معناته huge problemفالفكرة اللي
+
+1215
+01:54:08,320 --> 01:54:12,620
+لما نكون الـ Karyotype Problem يعني أنا بحكي مرة
+
+1216
+01:54:12,620 --> 01:54:17,100
+ثانية كنا قضيني الـ Down Syndrome اللي هو خمس
+
+1217
+01:54:17,100 --> 01:54:22,240
+وثلاثين مظهر يعني مش بس العيون والإيدان والطول
+
+1218
+01:54:22,240 --> 01:54:25,320
+والـ Mental Retardation والـ Delayed Development
+
+1219
+01:54:25,320 --> 01:54:29,320
+والـ Heart Disease والـ Didoenal Atresiaوالكذا
+
+1220
+01:54:29,320 --> 01:54:33,780
+والكذا والكذا كله بتلاقي بتخربط أشياء كثيرة بالسبب
+
+1221
+01:54:33,780 --> 01:54:41,740
+إنه هاي عدد كبير من الجينات مش single gene فتطوير
+
+1222
+01:54:41,740 --> 01:54:47,960
+أكثر للـ Sonar وفي عندنا مثلا إذا حد منكم حتى
+
+1223
+01:54:47,960 --> 01:54:52,920
+بيقدر يتابع أو بعرف في دكتور عندنا اسمه خالد
+
+1224
+01:54:52,920 --> 01:54:57,420
+سالاينة Pediatric Cardologistالـ Pediatric
+
+1225
+01:54:57,420 --> 01:55:05,520
+Cardiologists اللي هما الـ الـ الـ
+
+1226
+01:55:05,520 --> 01:55:06,420
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+1227
+01:55:06,420 --> 01:55:06,500
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+1228
+01:55:06,500 --> 01:55:06,900
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+1229
+01:55:06,900 --> 01:55:07,740
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+1230
+01:55:07,740 --> 01:55:10,240
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+1231
+01:55:10,240 --> 01:55:11,380
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+1232
+01:55:11,380 --> 01:55:16,220
+الـ الـ
+
+1233
+01:55:16,220 --> 01:55:17,660
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+1234
+01:55:17,660 --> 01:55:17,660
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+1235
+01:55:17,660 --> 01:55:17,660
+الـ الـ الـ الـ الـ ال
+
+1236
+01:55:22,580 --> 01:55:27,620
+إنه يصير إجهاض ويبدأ عملية إجهاض وكذا بس أحيانًا
+
+1237
+01:55:27,620 --> 01:55:31,160
+في مرحلة متأخرة من الحمل وإن ده الوضع كويس للأم
+
+1238
+01:55:31,160 --> 01:55:38,280
+وإشي simple و easy مش معقد ممكن يعني يعملوا عملية
+
+1239
+01:55:38,280 --> 01:55:44,140
+على الجنين technicalities بعرفهاش كتير فمن الأشياء
+
+1240
+01:55:44,140 --> 01:55:48,100
+اللي بتدرسنا الموضوع هذا إنه أنا أعمل fetal
+
+1241
+01:55:48,100 --> 01:55:53,990
+echocardiographyمن خلال الـ ECO اللي هو تبع فحص
+
+1242
+01:55:53,990 --> 01:56:00,910
+صدر القلب بنشوف الجنين وبنشوف
+
+1243
+01:56:00,910 --> 01:56:08,170
+شو المشكلة اللي عنده فهنا حاطيلكم بالأول نسب شو
+
+1244
+01:56:08,170 --> 01:56:11,150
+احتمالية إنه فيه congenital heart disease في اللي
+
+1245
+01:56:11,150 --> 01:56:16,110
+عنده هذا المرض هو هنا الـ Maternal Indicationsإذا
+
+1246
+01:56:16,110 --> 01:56:21,270
+الأم عندها type 1 diabetes mellitus اللي هو
+
+1247
+01:56:21,270 --> 01:56:24,470
+insulin dependent الـ congenital heart disease
+
+1248
+01:56:24,470 --> 01:56:32,150
+بالجنين 3% لـ 5% إذا بيكيو 15% Teratogen exposure
+
+1249
+01:56:32,150 --> 01:56:35,830
+نسبة أعلى الـ Thalidomide مشهور هذا، بتعرف قصته
+
+1250
+01:56:35,830 --> 01:56:42,270
+الـ Thalidomide دوة يعني بالخمسينات والستينات
+
+1251
+01:56:42,270 --> 01:56:50,800
+بالأولعبارة عن موضوع جيد جدًا لـ Nausea وأحيانًا
+
+1252
+01:56:50,800 --> 01:56:56,700
+بالذات مرضى السلطان أو مرضى أمراض كثيرة ممتاز جدًا
+
+1253
+01:56:56,700 --> 01:57:00,840
+جدًا جدًا من أحسن الحالات اللي ممتاز جدًا جدًا
+
+1254
+01:57:00,840 --> 01:57:07,080
+فيها التلوجاميد اللي هو الحمل فمعروف الحوامل
+
+1255
+01:57:07,080 --> 01:57:09,660
+يستفرغون
+
+1256
+01:57:12,820 --> 01:57:16,920
+الـ Hyperemesis Gravidarum بتسميه هذا من أحلى
+
+1257
+01:57:16,920 --> 01:57:21,480
+الأدوى وأحسن الأدوى له كان له شعبية كبيرة أمريكا
+
+1258
+01:57:21,480 --> 01:57:26,500
+رفضوا يدخلوه فانتشر كثير في أوروبا بعد انتشار هذا
+
+1259
+01:57:26,500 --> 01:57:34,460
+الدواء بسنين وأشهر لاقوا أنه كثير صار أطفال يطلعوا
+
+1260
+01:57:34,460 --> 01:57:41,580
+من غير إيدين ولا رجلين يعني كل اللمب طاير وثبت أنه
+
+1261
+01:57:41,580 --> 01:57:48,100
+من الثلاث دماغفالـ Thalidomide الآن للحوامل ممنوع
+
+1262
+01:57:48,100 --> 01:57:52,860
+خطر جدا ومع أنه يعني كان له شعبي بس لما ثبت أنه
+
+1263
+01:57:52,860 --> 01:57:59,060
+منه يعني بحتلوا الشركة وتغيرت أراء الأطباء وكذا
+
+1264
+01:57:59,630 --> 01:58:06,190
+فالـ Thalidomide نعرفه بطريقة معينة تقريباً مثلاً
+
+1265
+01:58:06,190 --> 01:58:10,650
+بس الـ Cancer أو الـ AIDS patient اللي بنعطيهم الـ
+
+1266
+01:58:10,650 --> 01:58:15,330
+Thalidomide لمن يكونوا مش كويسين يعني فالـ
+
+1267
+01:58:15,330 --> 01:58:19,490
+Thalidomide لدى Cancer exposure له نسبة الـ
+
+1268
+01:58:19,490 --> 01:58:23,290
+Congenital Heart Disease 10% الفيناتويل إذا كانت
+
+1269
+01:58:23,290 --> 01:58:29,010
+الأم تاخد Anti-epileptic الفيناتويل وجود الألكوهول
+
+1270
+01:58:29,740 --> 01:58:32,580
+الـ Maternal Congenital Heart Disease بزيد النسب
+
+1271
+01:58:32,580 --> 01:58:38,840
+هدولة يعني أمراض عند الأم المجموعة الثانية الـ
+
+1272
+01:58:38,840 --> 01:58:43,790
+Fetal Indicationsممكن الـ Abnormal Genital General
+
+1273
+01:58:43,790 --> 01:58:46,510
+Fetal Uterus Sound Examination Results أو إذا
+
+1274
+01:58:46,510 --> 01:58:49,570
+انتبهنا على الـ Arrhythmias لأنهم دائما يبحثون على
+
+1275
+01:58:49,570 --> 01:58:54,870
+أن القلب يبنبط بتحس أنه يبنبط الـ ECG ماعرفش إذا
+
+1276
+01:58:54,870 --> 01:59:02,530
+بتقدر، آه أظن بيحطوا الـ ECG للجنين وبيشوفوا الـ
+
+1277
+01:59:02,530 --> 01:59:05,690
+Arrhythmias تبعته إذا بنعرف إنه فيه Chromosomal
+
+1278
+01:59:05,690 --> 01:59:09,330
+Anomalies بالذات الـ Down Syndromeالـ Knuckle
+
+1279
+01:59:09,330 --> 01:59:13,770
+Thickening الـ Non-Immune Hydrophytalus إذا صار
+
+1280
+01:59:13,770 --> 01:59:19,190
+تكسر دم ممكن مع الـ Congenital Heart Disease أو
+
+1281
+01:59:19,190 --> 01:59:22,670
+إذا Family Syndrome زي الـ Mendelian Syndrome أو
+
+1282
+01:59:22,670 --> 01:59:25,850
+Paternal Congenital Heart Disease أو Privileged
+
+1283
+01:59:25,850 --> 01:59:33,530
+Child كل مرة بتزيد فأحياناًيعني هي اختلالات في
+
+1284
+01:59:33,530 --> 01:59:38,030
+الأم، اختلالات في نفس الجنين أو اختلالات في عائلة
+
+1285
+01:59:38,030 --> 01:59:43,590
+الأم والعائلة والأسرة هذه في العائلة تخلينا نروح
+
+1286
+01:59:43,590 --> 01:59:50,630
+ندور على Eco-cardiography على فحص صدر القلب للجنين
+
+1287
+01:59:50,630 --> 01:59:54,750
+الفكرة
+
+1288
+01:59:55,650 --> 02:00:01,890
+نرجح هنا، يمكن كان مفروض حطيناها جنب تبع الأسباب
+
+1289
+02:00:01,890 --> 02:00:07,730
+ليش الـ Alpha-Fetoprotein مرتفعة الإشكالية
+
+1290
+02:00:07,730 --> 02:00:11,950
+أنه حكينا
+
+1291
+02:00:11,950 --> 02:00:16,610
+أن أكثر شيء يرفعها الـ Spina Bifida اللي هو الـ
+
+1292
+02:00:16,610 --> 02:00:21,130
+Neuronal Tube Defect طبعاً هذه حالات نسأل الله
+
+1293
+02:00:21,130 --> 02:00:27,120
+سبحانه وتعالى أن يعافينا منهاومعتبروها congenital
+
+1294
+02:00:27,120 --> 02:00:32,020
+بس أكتر سبب له ومن اللي بيخففوا كثير الأسبانة بفدة
+
+1295
+02:00:32,020 --> 02:00:36,960
+اللي هو الـ Follet Replacement يعني عشان هيكي من
+
+1296
+02:00:36,960 --> 02:00:41,420
+الأشياء المهمة أنهالمجتمع أو الأطباء النسائية
+
+1297
+02:00:41,420 --> 02:00:46,520
+والحمل والمتابع هي أداة الحمل إنه يعطوا كل النساء
+
+1298
+02:00:46,520 --> 02:00:51,020
+الفولات ده لازم تكون تقضيتها كويسة لازم تأكل منه
+
+1299
+02:00:51,020 --> 02:00:55,120
+كويس بس لو في احتمال ما أكلتش أحسن نعطيها فولات
+
+1300
+02:00:55,120 --> 02:01:00,040
+فالفولات بيمنع الـ spinal بيفدى ويكون هذا المطلوب
+
+1301
+02:01:00,040 --> 02:01:06,020
+هنا بيعطيكم مثال إنه لو أنا جيتحطيت الـ Normal
+
+1302
+02:01:06,020 --> 02:01:11,800
+Distribution للـ Range of Normal Maternal Serum
+
+1303
+02:01:11,800 --> 02:01:15,980
+Alpha-Fetoprotein هنا طبعاً يعني مش تبع
+
+1304
+02:01:15,980 --> 02:01:19,000
+الأمانيوسينتيسيس اللي حكينا عنه
+
+1305
+02:01:22,150 --> 02:01:28,910
+بأخد دم الأم وبفحصها بالنسبة للـ Alpha-Feta
+
+1306
+02:01:28,910 --> 02:01:35,110
+Protein في الحمل بيزيد، بس إذا في حمل فيه Spinal
+
+1307
+02:01:35,110 --> 02:01:40,230
+Bifida فيه، النسبة أعلى بكتير وفي حالة الـ Down
+
+1308
+02:01:40,230 --> 02:01:45,400
+Syndrome، النسبة أقل بشكل ملحوظممكن ليس هناك فرق
+
+1309
+02:01:45,400 --> 02:01:51,000
+إحصائي بين الـ «أنا أفكتد» والـDown Syndrome بس
+
+1310
+02:01:51,000 --> 02:01:56,660
+الفكرة أنه كحالة بتسبب أنه فيه نقصان في الـ Alpha
+
+1311
+02:01:56,660 --> 02:02:00,280
+-Fetoprotein الـDown Syndrome والـSpina Fide بفي
+
+1312
+02:02:00,280 --> 02:02:04,480
+دا أقوى حالة أو Neuronal Tube Defect اللي بتعمل
+
+1313
+02:02:04,480 --> 02:02:09,680
+أنه الـAlpha-Fetoprotein عادي فهي شغل الواحد بنتبه
+
+1314
+02:02:09,680 --> 02:02:11,840
+لها الـ
+
+1315
+02:02:13,600 --> 02:02:22,520
+هذه حكينا عن أنه في أمراض كثيرة بالأم ماشي يعني
+
+1316
+02:02:22,520 --> 02:02:34,200
+هنا ناحية ثانية اللي هي أنه هنا
+
+1317
+02:02:34,200 --> 02:02:41,620
+أنه أنا بقدر أدرس أشياء معينة عن طريق فحص الأم
+
+1318
+02:02:41,620 --> 02:02:47,120
+نفسهاوبتكون أنه مثلًا أفحص الـ Alpha-Fetoprotein
+
+1319
+02:02:47,120 --> 02:02:53,120
+عند الأم بس بدي أتذكر أنه أنا أكبر مثل حكيته عن
+
+1320
+02:02:53,120 --> 02:02:58,540
+الـ Cause of Alpha-Fetoprotein increase اللي هو
+
+1321
+02:02:58,540 --> 02:03:04,040
+liver cancer و ال colon cancer بس هدولة بشكل عام
+
+1322
+02:03:04,040 --> 02:03:10,280
+اللي عندها سلطان ما بتحمله فيعني في الغالب ما بحط
+
+1323
+02:03:10,280 --> 02:03:16,740
+أناإن واحد عندها liver cancer أو colon cancer وحط
+
+1324
+02:03:16,740 --> 02:03:21,260
+إنه هذا من الـ cause of maternal serum alpha
+
+1325
+02:03:21,260 --> 02:03:25,080
+-fetoprotein concentration لأن هي ما راح تحمل
+
+1326
+02:03:25,080 --> 02:03:33,500
+بينما هنا حطين Antelope على أسباب أخرىفي الـ Skin،
+
+1327
+02:03:33,500 --> 02:03:37,500
+في الأم في الـ Spina Bifida؟ ماعرف إيش عاد قصده
+
+1328
+02:03:37,500 --> 02:03:40,380
+هنا، في الجنين ولا في الأم نفسها؟ إذا فيه
+
+1329
+02:03:40,380 --> 02:03:45,860
+Obstruction، إذا فيه Liver Damage؟ كل واحد، يعني،
+
+1330
+02:03:45,860 --> 02:03:52,080
+many types of diseases ممكن يخلي الـMaternal Alpha
+
+1331
+02:03:52,080 --> 02:03:54,340
+-Feta Protein الـConcentration high، بالتالي
+
+1332
+02:03:54,340 --> 02:03:57,600
+بتخليني أشك في إحدى من هذه الأشياء، وبالتالي
+
+1333
+02:03:57,600 --> 02:03:58,420
+أتعامل معها
+
+1334
+02:04:04,150 --> 02:04:13,850
+فالنقطة يعني الآن الخيارات اللي عندي إياها اللي هو
+
+1335
+02:04:13,850 --> 02:04:22,830
+يعني من خلال أنا اللي حكيته من أول إنه أنا عندي
+
+1336
+02:04:22,830 --> 02:04:27,810
+Ammoniac Fluid Sampling «قورينيك بيلاس» Sampling
+
+1337
+02:04:28,670 --> 02:04:36,230
+الـ In-vitro sampling والآن الـ Ultrasound هذه
+
+1338
+02:04:36,230 --> 02:04:40,310
+المثال الرابع اللي أنا حطينا أو جابوا مثاله على
+
+1339
+02:04:40,310 --> 02:04:46,650
+الـ Prenatal Screening الـ Ultrasound للحمل نفسه
+
+1340
+02:04:46,650 --> 02:04:52,570
+والنقطة اللي أضفناها قضية إن أنا ممكن أسحب دم من
+
+1341
+02:04:52,570 --> 02:04:59,990
+الأم ونتيجة اختلاط سواء الـ DNA لوحدهمن الجنين أو
+
+1342
+02:04:59,990 --> 02:05:04,830
+من خلايا الجنين مع الخلايا الأم إنه في الدم ممكن
+
+1343
+02:05:04,830 --> 02:05:10,110
+أنا ألاقي مؤشرات على abnormalities معينة ممكن
+
+1344
+02:05:10,110 --> 02:05:13,970
+تفيدني مثل Alpha-Fetoprotein فهنا حلاوة الـ
+
+1345
+02:05:13,970 --> 02:05:17,910
+Maternal Serumمثلًا، تجارب بشكل بسيط، بسهولة،
+
+1346
+02:05:17,910 --> 02:05:23,050
+وليست مهيجة للجنين، ولا تحصل على إحتماليات مثل الـ
+
+1347
+02:05:23,050 --> 02:05:27,210
+Amniotic وCorionic Blood Sampling لتعمل الـ
+
+1348
+02:05:27,210 --> 02:05:35,070
+Damage، فهذا يكون أسهل، لكن هذه النوع من التجارب
+
+1349
+02:05:35,290 --> 02:05:39,090
+فيه له محاضير كثيرة ومرات ما بستفيدش منها في أشياء
+
+1350
+02:05:39,090 --> 02:05:42,630
+كثيرة فالـ Alpha-Fetoprotein Concentration هذا الـ
+
+1351
+02:05:42,630 --> 02:05:47,170
+Maternal ممتاز وسهل وبسيط وممكن يصيدي أشياء كثيرة
+
+1352
+02:05:47,170 --> 02:05:51,290
+من
+
+1353
+02:05:51,290 --> 02:05:59,410
+الأشياء الثانية اللي بنعملها اللي هي أنه ممكن
+
+1354
+02:05:59,410 --> 02:06:04,350
+أنا الـ Alpha-Fetoprotein نقول اللي ذكرناهافي عندي
+
+1355
+02:06:04,350 --> 02:06:08,030
+الـ HCG اللي هو الـ Human Coronary Gonadotrophin
+
+1356
+02:06:08,030 --> 02:06:17,330
+تبع الحمل كهرمون وفيه إشي اسمه N-HPNA وفيه other
+
+1357
+02:06:17,330 --> 02:06:24,850
+يعني parameters زي ارتخائر الرقبة أو Nuclear
+
+1358
+02:06:24,850 --> 02:06:32,580
+Translucency وفيه إشي اسمه اللي هوHuman Corionic
+
+1359
+02:06:32,580 --> 02:06:36,360
+Gonadotropin Beta-subunit أو الـ Pregnancy Assured
+
+1360
+02:06:36,360 --> 02:06:40,960
+Plasma Protein A بي إيه بي إيه بي إيه بي إيه بي
+
+1361
+02:06:40,960 --> 02:06:45,240
+إيه بي إيه بالشكل هذا أو بي إيه بي إيه بي إيه هذا
+
+1362
+02:06:45,240 --> 02:06:56,880
+الفكرة أنه يعني هذه الأشياء هنا بفحصها هنا هي بالـ
+
+1363
+02:06:56,880 --> 02:07:02,980
+ultrasoundوهدولة عن طريق الـ Maternal Serum يعني
+
+1364
+02:07:02,980 --> 02:07:07,440
+بسحب الـ Serum تبعتها وهنا بحكي لكم أن أحياناً أنا
+
+1365
+02:07:07,440 --> 02:07:12,680
+ممكن أشخص أشياء كثيرة إذا بشوف Anomalies بشكل
+
+1366
+02:07:12,680 --> 02:07:18,660
+معين، ماشي؟ فالـ Trisomy 121 Down Syndrome أو أكثر
+
+1367
+02:07:18,660 --> 02:07:23,920
+واحد، بس ممكن 18 و 13، نسبهم أقل وإذا فيه Neuronal
+
+1368
+02:07:23,920 --> 02:07:28,410
+Tube Defect برضه سيءالنيرونال بالنسبة لنا بيفدى
+
+1369
+02:07:28,410 --> 02:07:33,590
+الطفل بيطلع طبيعي من فوق يعني paraplegia يعني شلل
+
+1370
+02:07:33,590 --> 02:07:39,070
+بالنصف السفلي بس مرات الـ Neuronal Cube Defect إذا
+
+1371
+02:07:39,070 --> 02:07:42,590
+من جهة اللي فوق أنا انكفلي و أشياء ثانية ممكن تكون
+
+1372
+02:07:42,590 --> 02:07:47,330
+Very Very Severe فهنا هاي إذا عائلة في عندها مشكلة
+
+1373
+02:07:47,330 --> 02:07:56,850
+ممكن شو اسمها؟أفحص هذه الأشياء وهنا بأفحصها بالـ
+
+1374
+02:07:56,850 --> 02:08:01,550
+First Trimester ثلث الأول للحمل، من تسعة شهور وأو
+
+1375
+02:08:01,550 --> 02:08:05,790
+الثلث الثاني بلاقي إن بقدر أفحص على أشياء ثانية
+
+1376
+02:08:05,790 --> 02:08:10,410
+وبقدر من خلالهم أشخص أشياء معينة الـ Alpha-Beta
+
+1377
+02:08:10,410 --> 02:08:13,490
+-Protein أهم واحد وهذا اللي بديها وبيكون مع الـ
+
+1378
+02:08:13,490 --> 02:08:19,090
+Neuronal Tube Defect البقية، يعني تفاصيلها، يعني
+
+1379
+02:08:19,090 --> 02:08:22,970
+حاطين إشي برتفع، إشي بنزلفهذه بدأت تكون لـ
+
+1380
+02:08:22,970 --> 02:08:28,630
+Pediatrician أو Gynecologist أوبستاتريشن تبع طبيب
+
+1381
+02:08:28,630 --> 02:08:32,970
+حوامل إذا كان أثير موضوع إنه فيه كان طفل أول عنده
+
+1382
+02:08:32,970 --> 02:08:40,430
+مشكلة والآن بقالنا طفل ثاني من الأشياء المهمة اللي
+
+1383
+02:08:40,430 --> 02:08:49,830
+هي موضوع إنه الإنسان بنسميه Mosaic الفكرة
+
+1384
+02:08:49,830 --> 02:08:58,240
+إنهالإنسان لما يكون في البطل أمه في الحمل بيكون
+
+1385
+02:08:58,240 --> 02:09:06,900
+يعني الانسان هو في مجال اختلاط الخلايا بين الأم
+
+1386
+02:09:06,900 --> 02:09:13,800
+وبين الجنين فبالـ Peripheral blood للأم بيكون بعض
+
+1387
+02:09:13,800 --> 02:09:21,140
+الخلايا أجت من الجنين فبالتالي هنا حاطينأسلوب معين
+
+1388
+02:09:21,140 --> 02:09:26,400
+للدراسة اللي هو «Non-invasive prenatal screening»
+
+1389
+02:09:26,400 --> 02:09:33,920
+نسميه «NIPS» «Non-invasive prenatal screening» هنا
+
+1390
+02:09:33,920 --> 02:09:38,220
+إذا الواحد عنده جهاز قادر على أن يعمل هذا الأشي
+
+1391
+02:09:38,220 --> 02:09:47,680
+اللي راح يسوي إنه راح يسحب دم الأنثى بـ
+
+1392
+02:09:47,680 --> 02:09:53,710
+«peripheral blood»بعرفش هو من الـ Serum بيعملوا
+
+1393
+02:09:53,710 --> 02:09:57,970
+License للـ Cells كلها وبعدين بياخدوها كلها المهم
+
+1394
+02:09:57,970 --> 02:10:03,030
+بيعزلوا الـ DNA تبع كل الأشياء اللي موجودة في الـ
+
+1395
+02:10:03,030 --> 02:10:07,610
+Serum بالـ Maternal Serum فـ Cell-free DNA الـ
+
+1396
+02:10:07,610 --> 02:10:14,650
+Maternal Serum هذا الغالبية العظمى جدا منه من الأم
+
+1397
+02:10:14,650 --> 02:10:24,600
+بس بيظل الإنسان في عنده شوية DNAمن الـ Fetus يعني
+
+1398
+02:10:24,600 --> 02:10:32,960
+فيه يعني هذا مصطلح نستخدمه حتى في المناعة نسميه
+
+1399
+02:10:32,960 --> 02:10:40,560
+لأن الإنسان is a chimera chimera هو مخلوق يعني
+
+1400
+02:10:40,560 --> 02:10:46,580
+خيالي بالأساطير الرومانية واليونانية إنه شخصين في
+
+1401
+02:10:46,580 --> 02:10:51,880
+جسم واحدمرات بالرسوم المتحركة فيجيبولك راسين في
+
+1402
+02:10:51,880 --> 02:10:57,580
+جسم واحد أو شخصين أو اثنين ملتصقين زي توائم سيامية
+
+1403
+02:10:57,580 --> 02:11:03,680
+أو الكايميرة نفسها راس إنسان أو راس أسد جسم أسد
+
+1404
+02:11:03,680 --> 02:11:08,680
+وراس إنسان ودال حي وإجران فيل وخرطوم مش عارف إيش
+
+1405
+02:11:08,680 --> 02:11:13,620
+زي الحي يعني أنه من أكثر من جزء فهنا اللي بيسووا
+
+1406
+02:11:13,620 --> 02:11:21,680
+أنه بعزلوا الـ DNAالـ Free في الـ Serum تبع الأم
+
+1407
+02:11:21,680 --> 02:11:29,020
+فشغلة صحبة دم بسيطة باجي بعمل اللي هو NGS اللي هو
+
+1408
+02:11:29,020 --> 02:11:37,880
+الـ Next Generation Sequencing للواحد يعرف شو
+
+1409
+02:11:37,880 --> 02:11:43,420
+الأسماء مرات معقد الشغلفهي يعني جهاز Sequencer
+
+1410
+02:11:43,420 --> 02:11:47,620
+يعني بيقرأ الـ«نيكلوتايدز» بشكل سريع جداً جداً
+
+1411
+02:11:47,620 --> 02:11:53,480
+يعني فاق السرعة بكمبيوتر سريع جداً الفكرة أنه لما
+
+1412
+02:11:53,480 --> 02:12:01,460
+نقرأ القطع هذه ونكون عارفين عنها بالأخير نقدر نعدد
+
+1413
+02:12:01,460 --> 02:12:05,300
+شو هي الـCopies ومن أنه كرمزوم هذه القطعة اللي
+
+1414
+02:12:05,300 --> 02:12:09,680
+قرناهافهي يعني نوع من زي الـ Human Genome Project
+
+1415
+02:12:09,680 --> 02:12:15,360
+بس سريع جدًا جدًا وبسرعة الاهتمام هنا في المثال
+
+1416
+02:12:15,360 --> 02:12:22,800
+هذا إنه أشوف كام copy من أي chromosome أنا بتكلم
+
+1417
+02:12:22,800 --> 02:12:26,720
+عنه فالأصل ألاقي two chromosome ones، two
+
+1418
+02:12:26,720 --> 02:12:29,960
+chromosomes two، كذا كذا إذا لقيت three
+
+1419
+02:12:29,960 --> 02:12:35,040
+chromosomes twenty-two ممكن أقول إنه عدد ال copies
+
+1420
+02:12:35,040 --> 02:12:40,550
+هنا أكتر أوفي Unplied أو Uplied أو Duplied إذا في
+
+1421
+02:12:40,550 --> 02:12:44,870
+سواء لـ One Chromosome أو كل الكرمزومات أو Half
+
+1422
+02:12:44,870 --> 02:12:49,010
+Chromosomes يعني هل في One-End، Two-End، Three
+
+1423
+02:12:49,010 --> 02:12:55,250
+-End، Four-End، Six-End أو كده فالفكرة
+
+1424
+02:12:55,250 --> 02:13:03,730
+الآن هو المثال اللي حطيناه هنا يعني اللي بدل واحد
+
+1425
+02:13:03,730 --> 02:13:08,670
+ينتبهله أنهفي أشياء يمكن يفضل تنعمل بالـ First
+
+1426
+02:13:08,670 --> 02:13:15,770
+Trimester بس في أشياء ممكن نصير أه و الله نقدر
+
+1427
+02:13:15,770 --> 02:13:20,130
+نستفيد منها أكتر لما نعملها بالثلاث شهور التاني
+
+1428
+02:13:20,130 --> 02:13:25,070
+بين الشهر الرابع للسادس فإنه أنا بسوي المتابعة على
+
+1429
+02:13:25,070 --> 02:13:29,330
+أكتر من شهر وعلى أكتر من محل أني أدور على أي شيء
+
+1430
+02:13:29,330 --> 02:13:34,590
+معينفهنا الـ Chimerism
+
+1431
+02:13:34,590 --> 02:13:40,610
+أو الـ Mosaicism إنه الـ DNA من أكتر من مصدر وأنا
+
+1432
+02:13:40,610 --> 02:13:48,850
+بروح بشوف خواص الـ DNA تبع الجنين وبحكم من خلاله
+
+1433
+02:13:48,850 --> 02:13:52,990
+على إنه فيه مشكلة في الجنين وممكن أشخص أسريع معينة
+
+1434
+02:13:53,610 --> 02:13:57,690
+في مقابل إن هذا فحص بسيط وسهول ومن الأم بسحب نتفة
+
+1435
+02:13:57,690 --> 02:14:03,690
+الدم وبعطيه مؤشر شهو الجنين عنده وهذا بستخدم فيه
+
+1436
+02:14:03,690 --> 02:14:09,310
+NIPS وبستخدم فيه NGS Next Generation Sequencing
+
+1437
+02:14:09,310 --> 02:14:18,510
+فحتى الفكرة لما على الأقل هذا من خلال دراسة معينة
+
+1438
+02:14:18,510 --> 02:14:22,950
+طلعت سنة 2014الـ New England Journal of Medicine
+
+1439
+02:14:22,950 --> 02:14:30,510
+إنه الـ First Trimester Triple Screen اللي حكينا
+
+1440
+02:14:30,510 --> 02:14:36,130
+عنه هنا الـ Nucleotide Transducency و الـ BPA و
+
+1441
+02:14:36,130 --> 02:14:43,830
+الـ Free Beta-HCG و لا كذاالـ Sensitivity 85% والـ
+
+1442
+02:14:43,830 --> 02:14:50,030
+False Positive Rate 5% أحنا بيهمنا كل ما يكون هذا
+
+1443
+02:14:50,030 --> 02:14:56,190
+Sensitivity أكثر وSpecificity أقل Sensitivity إن
+
+1444
+02:14:56,190 --> 02:15:00,050
+المرض اللي عنده مرض نطلع إنه فعلا مريض
+
+1445
+02:15:00,050 --> 02:15:05,250
+وSpecificity إنه سليم نطلع إنه سليم يعني هنا
+
+1446
+02:15:05,250 --> 02:15:10,300
+الافتلاق بينهمهم عادةً العلاقة بينهم عكسية كل ما
+
+1447
+02:15:10,300 --> 02:15:13,620
+بدأ أزود الـ sensitivity بقلل الـ specificity هيك
+
+1448
+02:15:13,620 --> 02:15:18,620
+العلاقة على نفس الـ test الواحد في الحالة الواحدة
+
+1449
+02:15:18,620 --> 02:15:22,480
+أما لما يكون عندي أكتر من إيشي وأسوي أشياء مختلفة
+
+1450
+02:15:22,480 --> 02:15:27,120
+الـ non-invasive prenatal screening كله لما نعمله
+
+1451
+02:15:27,120 --> 02:15:33,820
+بالكاملأكتر من 99% sensitivity وأقل من 1%
+
+1452
+02:15:33,820 --> 02:15:43,120
+specificity بس هاد برضه أرقام مهمة فالفكرة أنه الـ
+
+1453
+02:15:43,120 --> 02:15:50,040
+Non-invasive Screening
+
+1454
+02:15:50,040 --> 02:15:57,420
+الأصل يكون هو الأول وأنا يعني ممكن كـConsultant
+
+1455
+02:15:58,030 --> 02:16:01,970
+ويجيني عائلة عندهم مشكلة أو عندهم حالة بدهم يسوي
+
+1456
+02:16:01,970 --> 02:16:07,770
+دراسة عليها الأصل أنه بالأول أبدأ أو يكون عندي خطة
+
+1457
+02:16:07,770 --> 02:16:12,850
+الطريق، خارطة الطريق، «شو بدي أعمل؟» بالترتيب، في
+
+1458
+02:16:12,850 --> 02:16:18,710
+كل حالة فعادة أو الأصل أو الأحسن أنه أبدأ بإنه
+
+1459
+02:16:18,710 --> 02:16:23,290
+أعمل «Non-invasive Screening» في الـ«أول عام» وفي
+
+1460
+02:16:23,290 --> 02:16:27,650
+«الثانوية عامة» وفي مش عارف إيش وكدهطبعاً حتى في
+
+1461
+02:16:27,650 --> 02:16:31,790
+الـ first trimester أو في مرحلة مبكرة ممكن أحتاج
+
+1462
+02:16:31,790 --> 02:16:36,230
+أحياناً كوريانيك بيللسامبلينج أو menu synthesis أو
+
+1463
+02:16:36,230 --> 02:16:40,850
+الـ invasive testing وممكن أني أصل في مرحلة أن
+
+1464
+02:16:40,850 --> 02:16:44,450
+أقول لأ والله الفحص negative والأمور إن شاء الله
+
+1465
+02:16:44,450 --> 02:16:48,350
+سليمة وأقولهم مافي داعي تخلقوا إن شاء الله الأمور
+
+1466
+02:16:48,350 --> 02:16:53,350
+كويسة وknow that the testing is neededمش ممكن
+
+1467
+02:16:53,350 --> 02:16:59,030
+نعمله أو لأنه خلاص النتيجة طلعت إيجابية فهي النقطة
+
+1468
+02:16:59,030 --> 02:17:09,470
+يعني كملخص للفصل هذا إنه إحنا لما نتعامل مع
+
+1469
+02:17:09,470 --> 02:17:18,900
+الأمراض الوراثية في عندنا جوانب بالأول بنسويهافي
+
+1470
+02:17:18,900 --> 02:17:27,100
+ما قبل الزواج أحيانًا أحيانًا يعني عند الولادة
+
+1471
+02:17:27,100 --> 02:17:31,060
+المفروض يكون فيه نوع من الـ Screening ويكون للطفل
+
+1472
+02:17:31,060 --> 02:17:36,280
+سليم وولادة طبيعية برضه بعمل بعض الفحوصات عشان
+
+1473
+02:17:36,280 --> 02:17:41,840
+أستثنى بعض الأمراض هدولة ممكن سهلات وخفيفات وعادة
+
+1474
+02:17:41,840 --> 02:17:46,280
+Simple بس في حاجة وهدولة في الغالب يعني بنسميها
+
+1475
+02:17:46,280 --> 02:17:51,530
+Screen لـGeneral Populationللأموم الناس أما لما
+
+1476
+02:17:51,530 --> 02:17:56,370
+يصير عندى حالة أنه عائلة عندهم مشكلة وأنا كـ
+
+1477
+02:17:56,370 --> 02:18:01,830
+consultant وكذا وبيهمني أني أتأكد كيف أتعامل مع
+
+1478
+02:18:01,830 --> 02:18:05,310
+هذا الموضوع وكل اللي بنحكي عنه invasive و non
+
+1479
+02:18:05,310 --> 02:18:10,570
+-invasive وscreening وكذا وكذا في حالة إذا فكرة
+
+1480
+02:18:10,570 --> 02:18:15,560
+أنه يكون فيه abortionأو نوع من الـ Abortion مقبول
+
+1481
+02:18:15,560 --> 02:18:19,740
+أو في حالة إن والله عندي إمكانيات أعمل والله رأيت
+
+1482
+02:18:19,740 --> 02:18:22,840
+الـ Congenital Heart Disease أعمل جراحة للجنين في
+
+1483
+02:18:22,840 --> 02:18:29,320
+بطنه فهذه يعني النقاط فالمطلوب، المطلوب
+
+1484
+02:18:29,320 --> 02:18:35,740
+للـConsultant أنه يكون عنده خارطة طريقة بهذا
+
+1485
+02:18:35,740 --> 02:18:40,870
+المثال، بهذه الطريقة يكون منتبهطبعًا يعني الـ
+
+1486
+02:18:40,870 --> 02:18:43,310
+«سلايد» اللي قبل شوية «الخاصية» «الخاصية»
+
+1487
+02:18:43,310 --> 02:18:43,870
+«الخاصية» «الخاصية» «الخاصية» «الخاصية» «الخاصية»
+
+1488
+02:18:43,870 --> 02:18:44,630
+«الخاصية» «الخاصية» «الخاصية» «الخاصية» «الخاصية»
+
+1489
+02:18:44,630 --> 02:18:45,090
+«الخاصية» «الخاصية» «الخاصية» «الخاصية» «الخاصية»
+
+1490
+02:18:45,090 --> 02:18:45,510
+«الخاصية» «الخاصية» «الخاصية» «الخاصية» «الخاصية»
+
+1491
+02:18:45,510 --> 02:18:46,910
+«الخاصية» «الخاصية» «الخاصية» «الخاصية» «الخاصية»
+
+1492
+02:18:46,910 --> 02:18:49,170
+«الخاصية» «الخاصية» «الخاصية» «الخاصية» «الخاصية»
+
+1493
+02:18:49,170 --> 02:18:56,950
+«الخاصية»
+
+1494
+02:18:56,950 --> 02:19:01,330
+«الخاصية
+
+1495
+02:19:01,680 --> 02:19:09,460
+والـ True Negative لأنه يقدر يقود الأهل في هذه
+
+1496
+02:19:09,460 --> 02:19:16,140
+النقاط من خلال كل الخيارات المتاحة سواء كـ
+
+1497
+02:19:16,140 --> 02:19:21,560
+Screening و Testing وبعد ذلك كعلاج فأظن هذا آخر
+
+1498
+02:19:21,560 --> 02:19:27,000
+Slide أو لأ، في واحد الـ Mosaicism يعني اللي هو
+
+1499
+02:19:27,000 --> 02:19:33,260
+أنه أحيانًافي نفس الطريق، يعني خلال نفس الحمل في
+
+1500
+02:19:33,260 --> 02:19:39,760
+مرحلة معينة ممكن تصير بعض الـ… الـMutations أو
+
+1501
+02:19:39,760 --> 02:19:50,240
+اختلالات بشكل معين يعني أنه يكون يعني فيه اختلالات
+
+1502
+02:19:50,240 --> 02:19:58,700
+بشكل يعني هنا، يعني أخذوا مثل الـDeployedاللي هو
+
+1503
+02:19:58,700 --> 02:20:03,960
+الإنسان الطبيعي خلايا تبعات الإنسان الطبيعي خلايا
+
+1504
+02:20:03,960 --> 02:20:07,220
+الـDeploid إلا في الـOverheads والـSperms
+
+1505
+02:20:07,220 --> 02:20:11,800
+الـAneuploid يعني اللي هي مش طبيعية باختلال بشكل
+
+1506
+02:20:11,800 --> 02:20:19,440
+معين 3N، 4N أو 1N مثلا أو الـTrisomy، إشي زي هيك
+
+1507
+02:20:19,440 --> 02:20:27,100
+فلمّا مرات في الغالب هذه بتكون حادثةتحدث في بعض
+
+1508
+02:20:27,100 --> 02:20:31,180
+الخلايا في مرحلة مبكرة فهو أنا هأعطيكم المثال إنه
+
+1509
+02:20:31,180 --> 02:20:37,340
+هي في مرحلة الـ Plastomere وصار بعض الخلايا يعني
+
+1510
+02:20:37,340 --> 02:20:41,160
+صار فيها طفرة صارت خطرة بدل ما هي حمرا والحمرة هو
+
+1511
+02:20:41,160 --> 02:20:50,380
+الطبيعي فالخيارات متعددةفهنا لما أخذ خلية مثل ما
+
+1512
+02:20:50,380 --> 02:20:54,600
+حكينا تبعها الـ IVF وأدرسها فيه احتمال أن أخذ
+
+1513
+02:20:54,600 --> 02:20:58,720
+الخلية الطبيعية ويكون فيها خلايا مصابة موجودة أو
+
+1514
+02:20:58,720 --> 02:21:01,720
+بالعكس، أخذ خلية مصابة وغالبين باقية الخلايات
+
+1515
+02:21:01,720 --> 02:21:08,220
+خلايا طبيعية، فهذا احتمال، وبدأ أنتبه أنه أنا في
+
+1516
+02:21:08,220 --> 02:21:12,020
+مرات، يعني عندي أربع احتمالات أنا أحس أن عندي
+
+1517
+02:21:12,020 --> 02:21:17,710
+نوعين من الخلايافي الممكن إنه يكون طبعاً أنا لما
+
+1518
+02:21:17,710 --> 02:21:21,670
+أعمل Corionic Pillar Sampling باخد من خلايا هذا
+
+1519
+02:21:21,670 --> 02:21:27,210
+الجزء، ماشي على أساس إنه يكون معبر عن الطفل بس
+
+1520
+02:21:27,210 --> 02:21:32,410
+ممكن في المرحلة الـA إنه يكون تماماً معبر عن حالة
+
+1521
+02:21:32,410 --> 02:21:37,390
+الطفل إنه بلاقي الخلايا الـAbnormal وبلاقي الخلايا
+
+1522
+02:21:37,390 --> 02:21:41,090
+الـNormal وإنه فعلاً الجنين نفسه عنده الـNormal
+
+1523
+02:21:41,090 --> 02:21:46,420
+والـAbnormalبالإحتمال بيه أنا والله أخدت من الـ
+
+1524
+02:21:46,420 --> 02:21:50,620
+Corionic Pillus ولقيت فيه خلايا Abnormal بس
+
+1525
+02:21:50,620 --> 02:21:55,640
+بالصدفة يعني هو أنا لقيت الـNormal والـAbnormal
+
+1526
+02:21:55,640 --> 02:22:00,380
+والجنين كان Completely Normal فهاجي ويجي واحد يعمل
+
+1527
+02:22:00,380 --> 02:22:03,820
+الفحص ويلاقي خلايا Abnormal ينصح الأهل والله
+
+1528
+02:22:03,820 --> 02:22:06,900
+اعملوا إجهاض ويطلع الجنين كله Normal هذا احتمال
+
+1529
+02:22:06,900 --> 02:22:12,330
+وادي، يكون هنا mixtureالاحتمال ثالث كمان وارد أنه
+
+1530
+02:22:12,330 --> 02:22:17,070
+هذه الخلايا الـ Abnormal بس بالـ Placenta مش في
+
+1531
+02:22:17,070 --> 02:22:21,870
+الجنين نفسه، برضه هي راح تعمل مشكلة وبالعكس، في
+
+1532
+02:22:21,870 --> 02:22:27,990
+مرات أنه أنا بعمل الـ Velas Sample وبيطلع عندي
+
+1533
+02:22:27,990 --> 02:22:31,830
+Completely Normal بس نفس الجنين مصاب وانا ماكنتش
+
+1534
+02:22:31,830 --> 02:22:36,490
+عارف، مافادنيش كتير، غشن الفحص فكل هذه احتمالات
+
+1535
+02:22:36,490 --> 02:22:41,230
+واردة وبدأت تكون بالباللما واحد يقرر إنه أنا ضروري
+
+1536
+02:22:41,230 --> 02:22:44,050
+أعمل هذا الفحص، بقدر أعمل هذا، طبعاً من الأول بقدر
+
+1537
+02:22:44,050 --> 02:22:47,490
+أعمله، ده بحاجته، لأنه فيه مرات كتيرة في الناس أو
+
+1538
+02:22:47,490 --> 02:22:51,210
+أماكن في العالم، مافي مجال أن يعمل هذه الفحصات،
+
+1539
+02:22:51,210 --> 02:22:57,310
+ماشي؟ وبعدين، بدي الواحد يظل منفتح على إنه ممكن
+
+1540
+02:22:57,310 --> 02:23:02,150
+الفحص يكون يخدع ومش ممثل حقيقي عن شو هو وضع الجنين
+
+1541
+02:23:03,030 --> 02:23:07,530
+فهيك بنكون خلصنا محاضرتين تبعات الأسبوع هذا والله
+
+1542
+02:23:07,530 --> 02:23:13,030
+يعطيكم العافية وإذا في أسئلة يعني حد يتكلم أو
+
+1543
+02:23:13,030 --> 02:23:19,410
+نخليها لبداية الأسبوع الجاي وبعدين بالنسبة لـفي
+
+1544
+02:23:19,410 --> 02:23:23,050
+الـ «جروب» تبعت الـ «جروب» للـ «جالتكس» الـ
+
+1545
+02:23:23,050 --> 02:23:24,550
+«جالتكس» الـ «جالتكس» الـ «جالتكس» الـ «جالتكس»
+
+1546
+02:23:24,550 --> 02:23:29,230
+الـ «جالتكس» الـ «جالتكس» الـ
+
+1547
+02:23:29,230 --> 02:23:30,310
+«جالتكس» الـ «جالتكس» الـ «جالتكس» الـ «جالتكس»
+
+1548
+02:23:30,310 --> 02:23:30,310
+الـ «جالتكس» الـ «جالتكس» الـ «جالتكس» الـ
+
+1549
+02:23:30,310 --> 02:23:32,610
+«جالتكس» الـ «جالتكس» الـ «جالتكس» الـ «جالتكس»
+
+1550
+02:23:32,610 --> 02:23:35,730
+الـ «جالتكس» الـ «جالتكس» الـ «جالتكس» الـ
+
+1551
+02:23:35,730 --> 02:23:43,150
+«جالتكس» الـ
+
+1552
+02:23:43,150 --> 02:23:46,110
+«جالتكس
+
+1553
+02:23:46,160 --> 02:23:49,400
+الله يعافيكم ويرضى عليكم إن شاء الله تكون الأمور
+
+1554
+02:23:49,400 --> 02:23:55,700
+واضحة وتكون مستفيدين إن شاء الله الله حيكم أهلا و
+
+1555
+02:23:55,700 --> 02:23:58,220
+أهلا نشوفكم الأسبوع الجاية إن شاء الله
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/fBzW7egRH9k.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/fBzW7egRH9k.srt
new file mode 100644
index 0000000000000000000000000000000000000000..1abb9dfa9ea0f9f9d3783345ba49d8ae8bb775a9
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/fBzW7egRH9k.srt
@@ -0,0 +1,1793 @@
+1
+00:00:00,880 --> 00:00:05,640
+الجزء الـ slide هذا بعد ما اتكلمنا كيف الـ DNA
+
+2
+00:00:05,640 --> 00:00:12,620
+شكله وكيف تتم عملية انقسام الخلايا، أو نوعين
+
+3
+00:00:12,620 --> 00:00:17,560
+الانقسام بهدف إبقاء عدد الخلايا كما هما، اللي هو
+
+4
+00:00:17,560 --> 00:00:24,020
+الـ Mitosis، عشان يظل عدد الخلايا زي ما هما، والـ
+
+5
+00:00:24,020 --> 00:00:31,480
+Meiosis، اللي هو موضوع لما يكون اللي هو الانخسام
+
+6
+00:00:31,480 --> 00:00:35,780
+المنصف، حيث أنه يطلع عند الـ Gametes، وبالـ Males و
+
+7
+00:00:35,780 --> 00:00:41,780
+الـ Females، بتتبع خطوات قريبة من بعض على مرحلتين،
+
+8
+00:00:41,780 --> 00:00:47,140
+المرحلة الأولى بتبدأ الخلية 2N بتصير 4N، وبعدين
+
+9
+00:00:47,140 --> 00:00:53,770
+بتنقسم إلى الخلايا التابعة لها، اللي هو سواءً الـ Sperms
+
+10
+00:00:53,770 --> 00:00:59,970
+أو الـ Egg، اللي بتطلع. الآن الموضوع الثاني راح نبدأ
+
+11
+00:00:59,970 --> 00:01:06,910
+اليوم إحنا بعد ما بدأنا نحكي إنه الـ DNA هو المصدر
+
+12
+00:01:06,910 --> 00:01:11,450
+اللي بيحدد كيف راح يكون ترتيب البروتين، أو الـ
+
+13
+00:01:11,450 --> 00:01:17,990
+Primary Structure تبع البروتين، اللي هو ترتيب الـ
+
+14
+00:01:18,750 --> 00:01:21,290
+ترتيب الـ Amino Acids، اللي هو الـ Primary
+
+15
+00:01:21,290 --> 00:01:24,650
+Structure للبروتين، ويكون ترتيب الـ Amino Acids
+
+16
+00:01:24,650 --> 00:01:28,750
+طبعاً لازم تكونوا عارفين من الـ Biochemistry أنه في
+
+17
+00:01:28,750 --> 00:01:32,950
+عندنا عشرين أو واحد وعشرين Amino Acids حسب مرات يبقى
+
+18
+00:01:32,950 --> 00:01:38,230
+هيك، ولي هيك. فأحد هذه الطرق اللي هو حاطينها تحت
+
+19
+00:01:38,230 --> 00:01:42,110
+اللي هي هنا Abbreviations for Amino Acids، فعندنا
+
+20
+00:01:42,110 --> 00:01:50,100
+الألانين والأرجينين والأسباراجين بالشكل هذا، في
+
+21
+00:01:50,100 --> 00:02:00,360
+ثلاث أنظمة لكتابة أسماء الـ Amino Acids في الـ
+
+22
+00:02:00,360 --> 00:02:07,500
+... أنا والله خلّيني أشوف الكاميرا الـ ... إيه، قاعد
+
+23
+00:02:07,500 --> 00:02:12,400
+المشاركة؟ المشكلة زي الـ «زوم»، ما كنت أنا أدخل من
+
+24
+00:02:12,400 --> 00:02:18,530
+قبل، مش راضي ... إيش اسمه؟ stop recording, share
+
+25
+00:02:18,530 --> 00:02:24,150
+screen, start video
+
+26
+00:02:24,150 --> 00:02:29,450
+ناخذ التطبيق PowerPoint
+
+27
+00:02:51,820 --> 00:02:57,580
+وأقول له start my video. هذا الجهاز مش جهازي، ما هو
+
+28
+00:02:57,580 --> 00:03:05,960
+اسمه؟ مش جهازي؟ فمش عارف 100%. طيب، بالنسبة لهناك
+
+29
+00:03:05,960 --> 00:03:10,480
+ثلاثة أنظمة للتعريف، الـ «among us»، بالعشرين اللي
+
+30
+00:03:10,480 --> 00:03:15,780
+هما، يأخذ ثلاثة أحرف، مثل الألانين، أو حرف الـ A، أو بالرمز
+
+31
+00:03:15,780 --> 00:03:21,950
+الكامل ألانين. هذه أسماء الـ Amino Acids، وكثير من
+
+32
+00:03:21,950 --> 00:03:32,770
+الظواهر الحيوية والظواهر في حياة الإنسان نعتمد
+
+33
+00:03:32,770 --> 00:03:36,770
+على الـ Amino Acids، يعني مثلاً فينيل كيتونوريا، مرض نتيجة الفينيل ألانين Metabolism
+
+34
+00:03:36,770 --> 00:03:41,030
+Problem، أو مثلًا في عندنا Serine Protease، أو عندنا
+
+35
+00:03:47,430 --> 00:03:51,830
+كذا. فنستخدم كثير مصطلحات اللي دخلت بالـ Amino Acids
+
+36
+00:03:51,830 --> 00:04:01,330
+فالآن حتى نفهم القطع اللي فوق اللي هي الـ Genetic
+
+37
+00:04:01,330 --> 00:04:11,380
+Code، هذه طريقة ترميز الـ Amino Acids من خلال أحرف و
+
+38
+00:04:11,380 --> 00:04:16,020
+الـ Bases، أو الـ Nitrogenous Bases التابعة للـ
+
+39
+00:04:16,020 --> 00:04:21,000
+Nucleotides. فمن تركيب الـ DNA بنحوله لتركيب أو
+
+40
+00:04:21,000 --> 00:04:26,860
+ترتيب الـ Amino Acids. فلو كان اللي اكتشفوه العلماء
+
+41
+00:04:26,860 --> 00:04:36,760
+أنه لو كان الأمر بيكون من خلال Single Nucleotide
+
+42
+00:04:38,390 --> 00:04:45,410
+كان نقدر نعمل شفرة لـ 4 Amino acids، لو كان عندي
+
+43
+00:04:45,410 --> 00:04:50,870
+Two Nucleotides، بيؤثروا هم اللي بيعملوا الـ
+
+44
+00:04:55,700 --> 00:05:01,540
+الـ Coding أو التشفير أنه Two Amino Acids. فالأول
+
+45
+00:05:01,540 --> 00:05:05,380
+أربعة، فينا واحد من أربع احتمالات، والثاني أربع
+
+46
+00:05:05,380 --> 00:05:08,880
+احتمالات ثانية. ففي الحالة دي راح يكون ستة عشر
+
+47
+00:05:08,880 --> 00:05:15,560
+Amino Acids، نقدر نرمز إليها. فثبت إنه
+
+48
+00:05:15,560 --> 00:05:20,560
+لأ، هم ثلاثة، كل ثلاثة بنقرأهم مع بعض، وكل ثلاثة مع
+
+49
+00:05:20,560 --> 00:05:25,480
+بعض، برمزوا لـ Amino Acid واحد. فعشان هيك بنسميهم
+
+50
+00:05:25,480 --> 00:05:30,240
+Codon، أو Triplet، أو كذا، عبارة عن ثلاثة من الـ
+
+51
+00:05:30,240 --> 00:05:34,960
+Nucleotides، حتى يرمزوا لواحد من الـ Amino Acid
+
+52
+00:05:34,960 --> 00:05:38,980
+طبعاً أربعة بأربعة بأربعة بتصير أربعة وستين
+
+53
+00:05:38,980 --> 00:05:44,300
+فالأربعة والستون زيادة عن العشرين Amino Acid، بس
+
+54
+00:05:44,300 --> 00:05:47,960
+بتغطيهم، وراح نشوف كيف الأمور تتطور
+
+55
+00:05:52,380 --> 00:05:57,020
+الجدول هذا أمامكم، حاطين بالأول ما هي الـ First
+
+56
+00:05:57,020 --> 00:06:03,400
+Base، مرات بتكون U, C, A أو G. طبعاً الـ U لأنها حلت
+
+57
+00:06:03,400 --> 00:06:10,780
+في الـ RNA، مش الـ DNA. الـ RNA حلت بدل الـ T، الـ
+
+58
+00:06:10,780 --> 00:06:17,900
+Second Base، هذا اللي هو ترتيبهم U, C, A, G، وبعدين
+
+59
+00:06:17,900 --> 00:06:22,510
+هنا الـ Third Base، حاطينها بالترتيب. شوفوا عندنا
+
+60
+00:06:22,510 --> 00:06:29,290
+فبنلاحظ إذا كان عندنا ترتيب، مثلًا كودون ثلاثي UUU
+
+61
+00:06:29,290 --> 00:06:36,710
+هذا فلع الألانين. UUC فلع الألانين كمان. UUA لـ  C
+
+62
+00:06:36,710 --> 00:06:46,690
+UUG لـ C. CCU,  UCC,  UCA,  UCG  الـ PUA, Lucy، يعني
+
+63
+00:06:46,690 --> 00:06:52,150
+إنها أربعة وستين، بده رمز للعشرين
+
+64
+00:06:52,150 --> 00:06:56,610
+فيهم، فبيصير عنده تكرارات، بعض الـ Amino Acids يمكن
+
+65
+00:06:56,610 --> 00:07:01,090
+مالهاش غير، مثلًا زي الميثيونين، الـ AUG هذا
+
+66
+00:07:01,090 --> 00:07:04,810
+الترتيب تبعها، فالـ
+
+67
+00:07:09,290 --> 00:07:17,410
+الآن الترتيبات هذه، زي ما أنتم شايفين، عشان يكون الـ
+
+68
+00:07:17,410 --> 00:07:24,310
+... نرمز لـ 20 Amino Acids من خلال ثلاثيات من الـ
+
+69
+00:07:24,310 --> 00:07:29,470
+Nucleotides، ثلاثيات من الـ Nitrogen Bases بحيث أنه
+
+70
+00:07:29,470 --> 00:07:35,810
+يعطينا إياها. بس بدنا نلاحظ كمان شغل ثاني، إذا
+
+71
+00:07:35,810 --> 00:07:45,430
+بتنتبهوا للجدول، UAA وUAG وUGA، هدول stop codons
+
+72
+00:07:45,430 --> 00:07:51,870
+انتبهوا، هدول الثلاثة حاطينهم إنه يعني، عشان
+
+73
+00:07:51,870 --> 00:07:58,390
+القراءة تبدأ من محل معين، وتنتهي في محل معين. بالأول
+
+74
+00:07:58,390 --> 00:08:03,160
+لازم يكون عندي، أنا بدور على الـ start codon، هي لازم
+
+75
+00:08:03,160 --> 00:08:08,480
+يكون start codon، كده، مش
+
+76
+00:08:08,480 --> 00:08:16,620
+شايفين؟ أين برولين وكده، وفيه الـ stop codon، الـ stop codon عشان
+
+77
+00:08:16,620 --> 00:08:25,780
+يوقف قراءة الـ RNA في محل معين. هنا الـ start codon ما نش
+
+78
+00:08:25,780 --> 00:08:30,220
+شايفينه، بس
+
+79
+00:08:30,220 --> 00:08:35,730
+لازم يكون في محل بيخلي النظام
+
+80
+00:08:35,730 --> 00:08:42,850
+في قراءة الـ Messenger RNA. ويعني في عملية الـ
+
+81
+00:08:42,850 --> 00:08:47,570
+Transcription للـ DNA لـ Messenger RNA، بدي يقول له
+
+82
+00:08:47,570 --> 00:08:51,930
+ابدأ من هذه المكانة. فالمحل البداية لازم يكون ترتيب
+
+83
+00:08:51,930 --> 00:08:56,110
+معين، بيقول له ابدأ من هنا، وفي نفس الوقت في شيء
+
+84
+00:08:56,110 --> 00:09:01,620
+بيقول له انتهي هنا. فهذه النقطة اللي بدنا إياها، وهيك
+
+85
+00:09:01,620 --> 00:09:07,340
+النظام اللي بتتم من خلاله ترميز الـ Amino Acids
+
+86
+00:09:07,340 --> 00:09:11,820
+اللي بتدخل في ترتيب البروتين الناتج عن هذا الجين
+
+87
+00:09:11,820 --> 00:09:17,340
+فالجين هو اللي في الـ DNA هو اللي راح يعطينا الـ
+
+88
+00:09:17,340 --> 00:09:22,420
+Messenger RNA، هو اللي راح يعطينا إياه. فأظن هنا الـ
+
+89
+00:09:22,420 --> 00:09:28,040
+ATG، وطبعاً يعني الفكرة أنه إحنا بنقرأ الـ
+
+90
+00:09:28,040 --> 00:09:29,120
+Transcription
+
+91
+00:09:31,290 --> 00:09:35,970
+كل ثلاثة مع بعض، كل ثلاثة مع بعض، كل ثلاثة مع بعض
+
+92
+00:09:35,970 --> 00:09:40,650
+فالـ Transcription أعطانا الـ Messenger RNA، والـ
+
+93
+00:09:40,650 --> 00:09:46,490
+Translation راح تعطينا الـ Amino Acids. حاطين هنا
+
+94
+00:09:46,490 --> 00:09:54,590
+الأسماء اللي هي المفروض بالأحرف لـ Amino
+
+95
+00:09:54,590 --> 00:10:00,350
+Acids اللي بتدخل في تركيب البروتين هذا. فهذه اسمها
+
+96
+00:10:00,350 --> 00:10:07,490
+كلمات مهمة كثيرة، اللي هي أنه في عندي start codon، Start
+
+97
+00:10:07,490 --> 00:10:13,250
+codon، وبعدين ببدأ عملية Transcription، وعطينا
+
+98
+00:10:13,250 --> 00:10:19,110
+الـ Messenger RNA. الـ Messenger RNA، كل ثلاثة بدخل
+
+99
+00:10:19,110 --> 00:10:25,610
+فيه اللي هو Transfer RNA، بتتركب على الـ ribosome
+
+100
+00:10:25,610 --> 00:10:31,590
+اللي فيه Ribosomal RNA، على الـ Messenger RNA، بحيث
+
+101
+00:10:31,590 --> 00:10:38,430
+يقرأ الـ الـ الـ الـ البروتينات الموجودة، بحيث
+
+102
+00:10:38,430 --> 00:10:45,110
+يعطينا في النهاية البروتين. ماشي؟ فالـ translational
+
+103
+00:10:45,110 --> 00:10:49,210
+reading frame is determined by the AUG initiator
+
+104
+00:10:49,210 --> 00:10:53,840
+codon، اللي حفظنا عليه، والـ Subsequent Codewords
+
+105
+00:10:53,840 --> 00:10:56,200
+Specifying the Amino Acids are indicated in
+
+106
+00:10:56,200 --> 00:11:00,440
+blue. The two other potential frames are not
+
+107
+00:11:00,440 --> 00:11:09,560
+used. فالـ هنا الـ AUG هو البداية، يعني هذا
+
+108
+00:11:09,560 --> 00:11:16,920
+أجا Messenger RNA، عشان يكون خربط أو لا، إش لحظة
+
+109
+00:11:16,920 --> 00:11:23,140
+بيصير الـ Ribosome يبدأ يلف ويشبك عليه، وينتبه لحد
+
+110
+00:11:23,140 --> 00:11:28,220
+ما يشوف هدول، في ثلاثة، بعدين بيصير يقرأ فيهم. فهيك
+
+111
+00:11:28,220 --> 00:11:34,700
+الظاهرة اللي بتتم في عملية
+
+112
+00:11:34,700 --> 00:11:40,520
+بناء البروتين من الـ Messenger RNA من الـ DNA
+
+113
+00:11:40,520 --> 00:11:44,880
+وبتكون هي هيك موجودة. إن شاء الله الأمور واضحة
+
+114
+00:11:49,250 --> 00:11:54,110
+على الـ WhatsApp، احكولي إذا... أنا آسف جداً، اليوم غريب
+
+115
+00:11:54,110 --> 00:11:57,870
+يعني، إن شاء الله المرة الجاية بتكون أحسن، وأنا ما ني
+
+116
+00:11:57,870 --> 00:12:02,490
+عارف شو اللي صار يعني، بدا يمكن أعد فرمتة الـ hard
+
+117
+00:12:02,490 --> 00:12:07,670
+disk. إذا في أسئلة ابعتولي إياها على الـ WhatsApp
+
+118
+00:12:07,670 --> 00:12:14,510
+أنا أفتح الاثنين أثناء اللي نيجي نتطلع على بعض الـ
+
+119
+00:12:29,340 --> 00:12:35,840
+الآن هناك ترتيب مطلوب حتى يلف السلك تبع الـ DNA
+
+120
+00:12:35,840 --> 00:12:41,720
+على حاله. فيه إيش اسمه، الـ nucleosomes، وإيش اسمه
+
+121
+00:12:41,720 --> 00:12:47,020
+الـ histones، والاثنين مطلوبين حتى الـ DNA يلف على
+
+122
+00:12:47,020 --> 00:12:53,360
+حاله، بحيث يصير عملية برضه بالشكل المطلوب لعملية
+
+123
+00:12:53,360 --> 00:13:01,300
+الـ meiosis والـ mitosis. الـ ... الآن اتكلمت هيك
+
+124
+00:13:01,300 --> 00:13:07,520
+بشكل ... حتى يعني نفهم جانب آخر، وشو ضرورة الواحد
+
+125
+00:13:07,520 --> 00:13:14,520
+يكون فاهم هيك بشكل مبدأي، Concept، هيك الـ ... الـ ... الـ
+
+126
+00:13:14,520 --> 00:13:18,300
+... ليش الـ Nucleosomes والـ Histones؟ غير قضية
+
+127
+00:13:18,300 --> 00:13:23,820
+حاجة نقلها في عملية ... في عملية انقسام الخلية
+
+128
+00:13:24,820 --> 00:13:31,580
+اللي هي ظاهرة التحكم. إنه أحياناً كثيرة بتتم التحكم
+
+129
+00:13:31,580 --> 00:13:42,960
+بالـ DNA عن طريق آليات، Mechanisms، تستلزم أنه عدد
+
+130
+00:13:42,960 --> 00:13:49,420
+كبير من الجينات يتم تشغيلها في مكان معين، أو
+
+131
+00:13:49,420 --> 00:13:54,250
+توقيفها في مجال آخر. هذه إليها دخل أحياناً، أو إليها
+
+132
+00:13:54,250 --> 00:13:59,370
+دخل مهم في اللي بنسميهم الـ Polygenic Diseases
+
+133
+00:13:59,370 --> 00:14:06,330
+يعني الأمراض اللي فيها عدد كبير من الجينات
+
+134
+00:14:06,330 --> 00:14:12,250
+مشتركة بتسبب المرض. هذه بتكون إنه عدد كبير، مش جين واحد
+
+135
+00:14:12,250 --> 00:14:16,010
+يعني إحنا راح ناخد بعد شوية إنه بنقسم الأمراض
+
+136
+00:14:16,010 --> 00:14:21,340
+لثلاث أنواع، ورافعاً فيه كروموزومال، يعني كروموزوم كامل
+
+137
+00:14:21,340 --> 00:14:27,600
+زيادة، نقصان، كده، وفيه Mendelian يعني One-gene، اللي
+
+138
+00:14:27,600 --> 00:14:31,160
+هو اللي عامل المشكلة. ودول أمراض بشكل عام نادرة
+
+139
+00:14:31,160 --> 00:14:36,260
+الأمراض، غالبية العظمى زي السكري، الضغط، الربو،
+
+140
+00:14:36,260 --> 00:14:40,620
+كده. هذه أشياء بتلاقي أن مجموعة كبيرة من الجينات
+
+141
+00:14:40,620 --> 00:14:44,540
+بتؤثر
+
+142
+00:14:44,540 --> 00:14:50,610
+عليها. طريقة كيف إنه عدد كبير من الجينات، سواء تشتغل
+
+143
+00:14:50,610 --> 00:14:54,890
+كثير أو تشتغل قليل، أو كيف تختلط بطريقة معينة، أو
+
+144
+00:14:54,890 --> 00:14:59,270
+أخرى، بيعتمد على ما يسمى الـ Epigenetic Mechanisms
+
+145
+00:14:59,270 --> 00:15:04,510
+فالـ Epigenetic Mechanisms، أشهرها، من
+
+146
+00:15:04,510 --> 00:15:09,370
+غير اللي بيسموه Micro RNA، بتصير عملية الـ DNA
+
+147
+00:15:09,370 --> 00:15:14,820
+Methylation، يعني الـ Methyl Group بتيجي وتشبك على
+
+148
+00:15:14,820 --> 00:15:23,700
+قطعة معينة، أو على نيوكليوتايد معين في الـ DNA، لما
+
+149
+00:15:23,700 --> 00:15:30,920
+تصير عندي الـ DNA methylation، بتغير وظيفة الجين
+
+150
+00:15:30,920 --> 00:15:35,900
+هذا، وطريقة ثانية اللي هي الـ Modification لـ
+
+151
+00:15:35,900 --> 00:15:39,780
+Histone Tail، الـ Histone، والـ Nucleosomes، والـ
+
+152
+00:15:39,780 --> 00:15:44,650
+Histones، بيصير فيهم برضه عمليات «methylation»، وهدول
+
+153
+00:15:44,650 --> 00:15:48,290
+يعني بيغيروا
+
+154
+00:15:48,290 --> 00:15:54,510
+في شكل وظيفة الـ DNA، بس ما بيغيروا في ترتيب الـ
+
+155
+00:15:54,510 --> 00:15:57,310
+Nucleotides، ولا بيغيروا، يعني ما بنقدر نعتبرهم
+
+156
+00:15:57,310 --> 00:16:02,830
+طفرات. ما بنقدر نعتبرهم زي بقية الأمراض، لما ناخد
+
+157
+00:16:02,830 --> 00:16:07,590
+عليها الـ coding. فـ Epigenetic، يعني بيسموه علم
+
+158
+00:16:07,590 --> 00:16:14,740
+اللاجينوم، بيكون إنه فيه اختلالات في وظيفة الـ DNA على
+
+159
+00:16:14,740 --> 00:16:20,980
+مستوى عدد كبير من الجينات مع بعض، بكون نتيجة ظواهر
+
+160
+00:16:20,980 --> 00:16:25,180
+زي عملية الـ methylation للـ DNA، أو تغيير على الـ
+
+161
+00:16:25,180 --> 00:16:30,160
+histones، أو الـ nucleosomes، اللي مطلوبة حتى لف الـ
+
+162
+00:16:30,160 --> 00:16:34,320
+DNA بالشكل اللي بنشوفه فوق، حتى يعطينا كروموزوم شكل
+
+163
+00:16:34,320 --> 00:16:38,840
+مضغوط، يعرف يفصل عن بعضه. فيه آليات أخرى للـ
+
+164
+00:16:38,840 --> 00:16:45,140
+Epigenetics، نحكي عنها بعدين، بس يعني هي ظواهر
+
+165
+00:16:45,140 --> 00:16:53,540
+موجودة، وأشياء مهمة. هنا الفرق الكيميائي لـ Cytosine
+
+166
+00:16:53,540 --> 00:16:58,980
+مع الـ 5-Methylcytosine، وممكن 5
+
+167
+00:16:58,980 --> 00:17:04,030
+-Hydroxymethylcytosine، كيف إنه بتصير تغييرات للـ
+
+168
+00:17:04,030 --> 00:17:09,230
+DNA، على مستوى الـ DNA، لطبيعة الـ methylation، وهي
+
+169
+00:17:09,230 --> 00:17:18,550
+حسب درجتها وكمياتها، بتأثر على وظيفة الـ DNA. اليوم
+
+170
+00:17:18,550 --> 00:17:27,630
+والآن، نتيجة ظروفنا يعني يمكن راح يكون صعب أن أسمع
+
+171
+00:17:27,630 --> 00:17:31,430
+منكم، بس إذا فيها أي أسئلة، إن شاء الله بالـ group
+
+172
+00:17:31,430 --> 00:17:33,670
+أو بكذا، بنعملها مرة ثانية
+
+173
+00:17:36,640 --> 00:17:43
+
+223
+00:22:16,130 --> 00:22:21,410
+بتشوفوهم مثلاً قاعدين حوالي مئة عازف فالمئة مثلاً في
+
+224
+00:22:21,410 --> 00:22:26,370
+لحظة معينة بدك كلهم أو ربعهم أو جزء معين أو نوعي
+
+225
+00:22:26,370 --> 00:22:31,490
+معين يتنشطوا، الجزء بدك إياهم يتطبطبوا، فهذه كلها
+
+226
+00:22:31,490 --> 00:22:36,870
+واردة، يعني فهي ظاهرة بتحدث وهي ظاهرة تشارك في
+
+227
+00:22:36,870 --> 00:22:44,890
+التحكم في وظيفة الـ DNA، وبالتالي قد تكون لها يعني
+
+228
+00:22:45,370 --> 00:22:50,570
+دوراً في، حكينا الأمراض اللي بنعتبرها polygenic يعني
+
+229
+00:22:50,570 --> 00:22:55,190
+الأمراض اللي فيها ليس جين واحد، مش مندالية، راح
+
+230
+00:22:55,190 --> 00:22:59,290
+تكون الأمراض اللي هي زي الضغط والسكري والربو، أشياء
+
+231
+00:22:59,290 --> 00:23:05,290
+وراثية، أشياء تكثر في عائلات معينة، بس جزء منها
+
+232
+00:23:05,290 --> 00:23:10,070
+وراثي صحيح، ولكن مش مندالية، مش جين واحد هو المسبب
+
+233
+00:23:10,070 --> 00:23:10,510
+للمرض.
+
+234
+00:23:15,670 --> 00:23:21,130
+فأحياناً اللي بدنا
+
+235
+00:23:21,130 --> 00:23:25,630
+ننتبه له من الظواهر الأخرى اللي بتعمل، واحنا بنحاول
+
+236
+00:23:25,630 --> 00:23:32,310
+نُصفّ شو بيصير في جسم الإنسان أنه مثلاً
+
+237
+00:23:32,310 --> 00:23:38,390
+أنا لأني متأكد 100% من هذا الكلام، وفي جانب درسته
+
+238
+00:23:38,390 --> 00:23:43,510
+بشكل كبير بالنسبة للـ Protein تبع الـ
+
+239
+00:23:43,510 --> 00:23:46,750
+Immunoglobulin تبع اللي موجود بيشتغل في الـ B
+
+240
+00:23:46,750 --> 00:23:52,990
+-Lymphocyte، ماشي، الـ Immunoglobulin أنا عندي Two
+
+241
+00:23:52,990 --> 00:23:57,850
+copies of the DNA، واحد من أبوي واحد من أمي، أثنانهم
+
+242
+00:23:57,850 --> 00:24:03,650
+عليهم جزء من الـ DNA للـ Heavy Chain للـ Heavy
+
+243
+00:24:03,650 --> 00:24:08,090
+Chain، وفيه للـ Light Chain، أربع copies يعني اثنتين
+
+244
+00:24:08,090 --> 00:24:13,940
+اثنتين، والـ Heavy Chain واحد بواحد، ففيه Syntax بس في
+
+245
+00:24:13,940 --> 00:24:20,140
+أي خلية من الـ B-Lymphocyte لوحدها بتكون فقط نسخة
+
+246
+00:24:20,140 --> 00:24:24,120
+واحدة من الـ Heavy Chain ونسخة واحدة من الـ Light
+
+247
+00:24:24,120 --> 00:24:27,780
+Chain، هم اللي شغالين، بالنسبة للـ Heavy Chain كان
+
+248
+00:24:27,780 --> 00:24:32,060
+عندي خيارين، طلع لي خيار واحد، أو بس واحد هو الفعال،
+
+249
+00:24:32,060 --> 00:24:36,380
+الثاني بيبقى ساكن لأنه لا تتم عملية الـ
+
+250
+00:24:36,380 --> 00:24:40,500
+Transcription و Translation له، بالنسبة للـ Light
+
+251
+00:24:40,500 --> 00:24:44,600
+Chain، مع أن عندي أربع احتمالات، بس في أي خلية بيكون
+
+252
+00:24:44,600 --> 00:24:52,920
+واحد فقط هو اللي شغال، فاللي بدنا نذكره هنا أنه هذه
+
+253
+00:24:52,920 --> 00:24:57,760
+بدنا نسميه "mono-allelic expression"، يعني في هذه
+
+254
+00:24:57,760 --> 00:25:04,300
+الخلية، الـ DNA، الـ RNA، أو الناتج اللي هو نتيجة الـ
+
+255
+00:25:04,300 --> 00:25:11,780
+DNA بيكون من كوبي واحدة، فمثلاً هنا في عندي بنسميه
+
+256
+00:25:11,780 --> 00:25:15,540
+"mono-allelic expression"، وهنا "balanced
+
+257
+00:25:15,540 --> 00:25:18,860
+expression"، يعني الاثنين بيشتركوا أنه يصير عملية
+
+258
+00:25:18,860 --> 00:25:22,620
+الـ Transcription وبعدين Translation في اللوم، وفي
+
+259
+00:25:22,620 --> 00:25:25,980
+أحياناً بيكون عندي ظواهر اللي يسمونه "allelic
+
+260
+00:25:25,980 --> 00:25:29,720
+imbalance"، يعني هنا الغالبية العظمى جاي من هنا بس
+
+261
+00:25:29,720 --> 00:25:36,320
+هذاك موجود بس كمية قليلة، فالـ SNPs اللي موجودة في
+
+262
+00:25:36,320 --> 00:25:39,380
+الـ RNA، مش عارف ليش حطوا هاي الـ SNP بالذات اللي
+
+263
+00:25:39,380 --> 00:25:44,280
+هي Single Nucleotide Polymorphism، يعني الـ SNP
+
+264
+00:25:44,280 --> 00:25:49,120
+هدول هم القلائل اللي استخدمناهم عشان نعرف أن هاي
+
+265
+00:25:49,120 --> 00:25:54,560
+أجت من هذا، وهنا أجن بالنص من هنا وهنا، يعني الـ SNP
+
+266
+00:25:54,560 --> 00:25:58,800
+هو Single Nucleotide Polymorphism، راح نحكي عنه بعد
+
+267
+00:25:58,800 --> 00:26:06,420
+شوية، فمن خلاله بقدر أعرف أن نسخة الـ DNA اللي تم
+
+268
+00:26:06,420 --> 00:26:13,540
+الـ Transcription تبعها، بحيث أنه أعطاني الـ
+
+269
+00:26:13,540 --> 00:26:17,460
+RNA هذا، فالفكرة
+
+270
+00:26:17,460 --> 00:26:22,220
+هنا أنه صحيح أنا عندي جينين أو نسختين من الـ
+
+271
+00:26:22,220 --> 00:26:28,060
+Chromosomes ونسختين من الجينات وكذا، بس مش دائماً
+
+272
+00:26:28,060 --> 00:26:32,140
+أنه اثنين لازم اثنين يشتغلوا، أحياناً الاثنين
+
+273
+00:26:32,140 --> 00:26:36,860
+بيشتغلوا زي بعض تماماً وبكونوا موجودين، يعني مثلاً
+
+274
+00:26:36,860 --> 00:26:40,340
+الـ Hemoglobin في Alpha و Beta Chain، راح ناخذها،
+
+275
+00:26:40,340 --> 00:26:44,980
+الـ Beta Chain فيها نسخة واحدة، ونسختين شغالة، الـ
+
+276
+00:26:44,980 --> 00:26:50,500
+Alpha Chain فيه أربعة، لأنه فيه على كل كروموزوم Two
+
+277
+00:26:50,500 --> 00:26:57,220
+Alpha Chain Gene، فبيصير عندي أربعة مصادر ممكن أنا
+
+278
+00:26:57,220 --> 00:27:02,200
+آخذ أي واحدة منها، ممكن الأربعة كلهم يشتغلوا، ممكن بس
+
+279
+00:27:02,200 --> 00:27:05,500
+واحد اللي يشتغل، ممكن اثنين يشتغلوا، ممكن ثلاثة
+
+280
+00:27:05,500 --> 00:27:06,560
+يشتغلوا، ممكن الأربعة.
+
+281
+00:27:22,930 --> 00:27:30,130
+جاية من الـ Beta
+
+282
+00:27:30,130 --> 00:27:36,010
+-Gene الأصلي، والـ Beta-Gene موجودة في نسختين عندي،
+
+283
+00:27:36,010 --> 00:27:43,530
+واحدة من أبوي واحدة من أمي، فلما
+
+284
+00:27:43,530 --> 00:27:50,530
+نكون ندرس هذا الموضوع بشكل تفصيلي، من خلال دراسة
+
+285
+00:27:50,530 --> 00:27:54,550
+الفروق الدقيقة، حتكون على مستوى Single Nucleotide
+
+286
+00:27:54,550 --> 00:27:58,730
+Substitution، ليش SNP؟ ليش Single Nucleotide
+
+287
+00:27:58,730 --> 00:28:02,650
+Polymorphism؟ لما أستخدم هذه التقنية أني أنا أدرس
+
+288
+00:28:02,650 --> 00:28:08,350
+الجين هذا من وين أجا البروتين؟ هل هو من الكروموزوم
+
+289
+00:28:08,350 --> 00:28:11,290
+اللي أجا من أبوي ولا الكروموزوم اللي أجا من
+
+290
+00:28:11,290 --> 00:28:16,730
+أمي؟ بقدر أنا أدرس هذا الموضوع، فلما أجي أدرس هذا
+
+291
+00:28:16,730 --> 00:28:24,660
+الموضوع ما شاء الله، بلاقي إن أنا عندي أكثر من احتمال في
+
+292
+00:28:24,660 --> 00:28:29,500
+حالات، بتلاقي هذا الـ chromosome مثلاً، نفترض هذا الـ
+
+293
+00:28:29,500 --> 00:28:32,860
+chromosome اللي ورثته من أبوي، وكان في الجانب
+
+294
+00:28:32,860 --> 00:28:38,220
+الفلاني، يعني مثلاً ناخذ نفترض مثلاً افتراض اللي هو
+
+295
+00:28:38,220 --> 00:28:43,520
+مثلاً الـ ABO blood group، راح تلاقي إن هنا الموقع
+
+296
+00:28:43,520 --> 00:28:49,220
+تبع الـ ABO blood group، وهذا الـ "جينات" الـ "جين"
+
+297
+00:28:49,220 --> 00:28:55,240
+المسؤول عن هذه الخاصية أو هذه الـ Blood Group،
+
+298
+00:28:55,240 --> 00:29:00,200
+فاللي راح ألاقيه بالأخير هو أن أنا شايف الـ
+
+299
+00:29:00,200 --> 00:29:04,400
+Protein، الـ Protein من وين بده يجي؟ بده يجي من
+
+300
+00:29:04,400 --> 00:29:07,880
+الـ RNA، وبعدين بيعطيني الـ Protein.
+
+301
+00:29:10,370 --> 00:29:15,430
+لو أنا هنا في الفتحة هذه بالضبط، أنا بدرس على مستوى
+
+302
+00:29:15,430 --> 00:29:19,430
+شو صار للـ RNA، يعني لسه ما كملت أني أشوف شو هو الـ
+
+303
+00:29:19,430 --> 00:29:24,850
+Protein، وقفت التفاعل ووقفت الوضع، المرحلة المعينة،
+
+304
+00:29:24,850 --> 00:29:33,070
+ففي حالة الـ ABO System، ماشي، إذا واحد مثلاً أخذ
+
+305
+00:29:33,070 --> 00:29:41,980
+كروموزوم وعليه موقع TA من أبوه، وأخذ B من أمه، شو
+
+306
+00:29:41,980 --> 00:29:46,060
+اللي راح يصير في جسمه؟ راح تلاقي في الغالب Balanced
+
+307
+00:29:46,060 --> 00:29:52,940
+Expression، حتلاقي الـ A والـ B موجودة، ويعني اثنين هم
+
+308
+00:29:52,940 --> 00:29:58,940
+شغالين، واثنين موجودين بنفس الطريقة، بنفس الكمية، في
+
+309
+00:29:58,940 --> 00:30:07,480
+أوقات، أو في جينات أخرى بيكون، فعلاً عندي جينين طبعاً
+
+310
+00:30:07,480 --> 00:30:12,680
+خاصة، نسختين من نفس الجين، وأحياناً يعني مثلاً الـ
+
+311
+00:30:12,680 --> 00:30:16,160
+Alpha Chain تبعت الـ Hemoglobin فيها Two copies،
+
+312
+00:30:16,160 --> 00:30:20,640
+يعني Total يصير عندي أربعة، Two copies على One
+
+313
+00:30:20,640 --> 00:30:24,300
+chromosome، و Two copies على الـ chromosome الثاني،
+
+314
+00:30:24,300 --> 00:30:29,960
+فعندي أربعة، ولكن برغم وجود الأربعة، مش الأربعة كلهم
+
+315
+00:30:29,960 --> 00:30:34,180
+شغالين، لأ، بيكون عندي واحد بس شغال، فيه ظاهرة هي
+
+316
+00:30:34,180 --> 00:30:39,800
+بتحدث، وهي في المناعة بندرسها ونعرفها ونفهمها،
+
+317
+00:30:39,800 --> 00:30:44,560
+حتى بيسموها إن الواحد هذا لما ينجح ويشتغل ويكون هو
+
+318
+00:30:44,560 --> 00:30:48,640
+الناجح، بيسكر على الثانية، بيسموها Allelic Exclusion،
+
+319
+00:30:49,130 --> 00:30:56,490
+يعني إنه بمنع النسخ
+
+320
+00:30:56,490 --> 00:31:01,330
+الأخرى من الجينات إنها تشتغل، فاحنا بنقول ما بين
+
+321
+00:31:01,330 --> 00:31:07,070
+هدول الـ …
+
+322
+00:31:07,070 --> 00:31:13,330
+يعني ما بين هدول الـ Two Extremes أو الأشياء
+
+323
+00:31:13,330 --> 00:31:18,830
+المتطرفة، كثير إنه 100% قد بعض، اثنين، أو 100% بس واحد
+
+324
+00:31:18,830 --> 00:31:24,530
+والثاني صفر، يعني ما بين خمسين وخمسين وصفر ومئة، في
+
+325
+00:31:24,530 --> 00:31:29,630
+مرات حالات بتكون Unbalanced، يعني الـ gene بيشتغل
+
+326
+00:31:29,630 --> 00:31:33,530
+ثمانين، والـ gene بيشتغل عشرين، يعني هيك كلمة
+
+327
+00:31:33,530 --> 00:31:38,930
+Genomic Imprinting، لا والله ما فاهمها، مش هي اللي
+
+328
+00:31:38,930 --> 00:31:44,990
+مقصودة هنا، يعني القصد في الموضوع هذا إنه فيه آليات
+
+329
+00:31:44,990 --> 00:31:50,890
+للتحكم في الـ Transcription، بحيث إنه ممكن في ظواهر
+
+330
+00:31:50,890 --> 00:31:56,090
+تكون اثنين تماماً شغالين، واثنين على أقصى سرعة
+
+331
+00:31:56,090 --> 00:32:00,950
+شغالين، وأحياناً بيكون واحد بيشغل 100% والثاني صفر،
+
+332
+00:32:00,950 --> 00:32:08,290
+فهذه موجودة، وهدول يعني بدنا نفهمهم كظواهر، إما
+
+333
+00:32:08,290 --> 00:32:11,330
+بيكون عندي Balanced Expression، يا إما Unbalanced
+
+334
+00:32:11,330 --> 00:32:15,070
+Expression، يا إما Monoallelic Expression، والـ
+
+335
+00:32:15,070 --> 00:32:19,690
+Monoallelic Expression هي الـ Parental Germline
+
+336
+00:32:19,690 --> 00:32:24,470
+Genomic Imprinting، هذه حاطين Epigenetic Silencing،
+
+337
+00:32:24,470 --> 00:32:29,130
+Ovaries in Imprinted Region، أنا الـ Imprinting ما
+
+338
+00:32:29,130 --> 00:32:38,590
+بفهمهاش، يعني بيكون تسكير عليهم، الـ Monoallelic
+
+339
+00:32:38,590 --> 00:32:44,990
+Expression في الـ T-cells والـ B-cells هو بتمّ
+
+340
+00:32:44,990 --> 00:32:49,730
+خلال، بعدها قضية Somatic Rearrangement اللي هي قطع
+
+341
+00:32:49,730 --> 00:32:56,230
+ولصق في الـ DNA، بس هاي يعني فقط في الـ T-cells،
+
+342
+00:33:01,370 --> 00:33:08,590
+مرة ثانية، لما نقول "mono
+
+343
+00:33:08,590 --> 00:33:11,370
+expression" أو "balanced expression" أو
+
+344
+00:33:11,370 --> 00:33:16,910
+"imbalanced expression"، التفكير الأول هيك أنه
+
+345
+00:33:16,910 --> 00:33:21,070
+الأصل أننا جينين، نسختين، منهم الأصل أنه اثنتين
+
+346
+00:33:21,070 --> 00:33:26,070
+يشتغلوا، وهي أحياناً بتحدث، فبتكون أنه في اثنتين
+
+347
+00:33:26,070 --> 00:33:32,550
+شغالين، بس أحياناً أخرى بيكون، على مستوى إنه بس نسخة واحدة
+
+348
+00:33:32,550 --> 00:33:37,050
+هي اللي تشتغل، يعني هنا فقط الأزرق هو الشغال، الجين
+
+349
+00:33:37,050 --> 00:33:40,890
+الثاني اللي موجود على الـ Chromosome الأحمر ما له
+
+350
+00:33:40,890 --> 00:33:46,830
+أي دور أو فعالية في الجسم، في خلايا معينة، في جينات
+
+351
+00:33:46,830 --> 00:33:52,410
+محددة، في حالات معينة بتلاقي هذا الظاهر اللي بتصير
+
+352
+00:33:52,410 --> 00:33:57,190
+أنه كلها بس جين واحد، نسخة واحدة هي اللي شغالة،
+
+353
+00:33:57,190 --> 00:34:01,630
+الثاني مش شغالة، وأحياناً اثنين شغالين قد بعض،
+
+354
+00:34:01,630 --> 00:34:07,330
+وأحياناً واحدة أكثر من الثانية، ما أظن أنها مش صعبة،
+
+355
+00:34:07,330 --> 00:34:13,970
+يعني ماشي، الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+356
+00:34:13,970 --> 00:34:19,990
+الـ الـ الـ الـ
+
+357
+00:34:19,990 --> 00:34:23,670
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+358
+00:34:23,670 --> 00:34:24,830
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+359
+00:34:24,830 --> 00:34:26,430
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+360
+00:34:26,430 --> 00:34:27,450
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ  وأي
+
+361
+00:34:27,450 --> 00:34:33,350
+إنسان عنده Two، قليل من الممكن، يعني مثلاً الـ ABO
+
+362
+00:34:33,350 --> 00:34:41,610
+System فيه ثلاثة، قليل يا A يا B يا O، وبالتالي لما
+
+363
+00:34:41,610 --> 00:34:47,630
+يكون عند إنسان AB، اثنين شغالين، ماشي، لما يكون عنده
+
+364
+00:34:47,630 --> 00:34:52,230
+AO، الـ A شغال، الـ O مش شغال أصلاً ما فيه إشي،
+
+365
+00:34:52,230 --> 00:34:56,270
+يعني ما فيه شيء ناتج منه، هذا بدنا نسميه Unbalanced
+
+366
+00:34:56,270 --> 00:34:59,330
+Expression، الأول اللي هو الـ Mono، أقل لك إذا كان
+
+367
+00:34:59,330 --> 00:35:05,450
+AB، إذا كان AO، أما إن، إذا الأصل AB، اثنين Co
+
+368
+00:35:05,450 --> 00:35:08,750
+-dominant، اثنين زي بعض بيشتغلوا، فبيبين الـ A
+
+369
+00:35:08,750 --> 00:35:15,290
+وبيبين الـ B، ماشي، للـ X-Chromosome، أنا اللي كنت
+
+370
+00:35:15,290 --> 00:35:19,350
+ناوي، يعني كنت قاعد بحكي اللي هو بالنسبة للـ X
+
+371
+00:35:19,350 --> 00:35:26,070
+-Chromosome بالذات، بتلاقي أحياناً الـ Infant الـ
+
+372
+00:35:26,070 --> 00:35:31,730
+Female اللي هي XX، الأصل أنه يكون، حتى لو عندها
+
+373
+00:35:31,730 --> 00:35:38,550
+Disease، جين نسخة واحدة و Recessive، الأصل أنها ما
+
+374
+00:35:38,550 --> 00:35:43,210
+يظهر عليها شيء، لأنها Carrier، لأن عندها ثاني شغال، بس
+
+375
+00:35:43,210 --> 00:35:50,110
+حقيقة، برغم أنه لو الـ disease X-linked Recessive،
+
+376
+00:35:50,820 --> 00:35:55,460
+بالرغم من أنه Recessive ويعني
+
+377
+00:35:55,460 --> 00:35:59,580
+الأصل، بما أن أنا عندها نسخة ثانية شغالة طبيعية،
+
+378
+00:35:59,580 --> 00:36:05,220
+كويسة، بتلاقيها، بعض النساء عندهم ظواهر للمرض، يعني
+
+379
+00:36:05,220 --> 00:36:12,260
+المتنحي اشتغل، السبب أنه بيصير عندي Random X
+
+380
+00:36:12,260 --> 00:36:16,140
+-Chromosome Inactivation، هذه ظاهرة بتحدث، أنه
+
+381
+00:36:16,140 --> 00:36:21,280
+بطريقة عشوائية، الخلية بتقرر إن واحد من هالـ X
+
+382
+00:36:21,280 --> 00:36:25,600
+-Chromosomes بدنا ما نستخدمه، خلاص نستخدم واحد
+
+383
+00:36:25,600 --> 00:36:31,320
+معين، طبعاً بتستخدمه لكل شيء، فبقول لما نستخدمه لكل
+
+384
+00:36:31,320 --> 00:36:37,880
+شيء، وكون هو المرض فيه كـ Recessive gene، Recessive
+
+385
+00:36:37,880 --> 00:36:44,340
+trait، ظاهرة متنحية، بتلاقيها تظهر، فهي بتفسر ليش
+
+386
+00:36:44,340 --> 00:36:51,450
+أحياناً بعض الأمراض اللي، حتى لو كان المرض متنحي،
+
+387
+00:36:51,450 --> 00:36:55,170
+والـ Female Carrier، الأصل أنه ما يظهر عليها شيء،
+
+388
+00:36:55,170 --> 00:36:59,390
+بيكون عند بعض مظاهر المرض، وهي تحدث في الـ Area of
+
+389
+00:36:59,390 --> 00:37:06,390
+Embryogenesis، يعني هنا اللي بدي أكون أخرجه فيه أنه
+
+390
+00:37:06,390 --> 00:37:14,410
+صحيح عندي أنا كروموزومات و DNA، وبنتج عنه RNA، وبنتج
+
+391
+00:37:14,410 --> 00:37:36,070
+عنه بعدين بروتين، بس، بس فيه نقطة
+
+392
+00:37:36,070 --> 00:37:43,570
+الأخيرة، من قبل أنا، على الأقل في غالبية الجينات، قد
+
+393
+00:37:43,570
+
+445
+00:43:05,380 --> 00:43:09,540
+هذه النقاط
+
+446
+00:43:09,540 --> 00:43:16,800
+هذه بتكون من خلال إنك أنت اللي طلعته من الإنسان
+
+447
+00:43:16,800 --> 00:43:22,280
+هذا أو من المريض، هذا أو من العائلة المريضة، أقوم
+
+448
+00:43:22,280 --> 00:43:30,080
+وأشوف شو هي الـ References للقطع هذه، شو بيحكوا
+
+449
+00:43:30,080 --> 00:43:35,480
+الموجود في الـ Human Genome Project في الـ
+
+450
+00:43:35,480 --> 00:43:39,420
+Database  بتاعة الـ SNPs اللي هو Single Nucleotide
+
+451
+00:43:39,420 --> 00:43:46,220
+Polymorphism اللي هو يعني أنه جزء من الموضوع/القضية
+
+452
+00:43:46,220 --> 00:43:52,100
+أنه اللي صرفوا عليه كثير من الأبحاث، بالذات اللي مش
+
+453
+00:43:52,100 --> 00:43:59,200
+بشكل تجاري، زي الحكومات أو الجامعات أو كده، بتلاقيهم
+
+454
+00:43:59,200 --> 00:44:03,520
+بيطلبوا أنه هذه المعلومة تكون مشاركة مع الجميع
+
+455
+00:44:03,520 --> 00:44:08,620
+يعني ما يكون هي ملك فقط للباحث بحيث يخبي عليها
+
+456
+00:44:08,620 --> 00:44:14,240
+وما يعطيها لحد تاني، فبيطلبوا أنه كل الناس تشارك في
+
+457
+00:44:14,240 --> 00:44:20,340
+أنه تحط الترتيب الـ Nucleotides اللي طلعتها، وترتيب
+
+458
+00:44:20,340 --> 00:44:24,800
+الـ Amino Acids والبروتين اللي طلعوا، والـ RNA اللي
+
+459
+00:44:24,800 --> 00:44:30,940
+طلعوا. فأهم مرجع للمصادر العلمية الآن، إذا واحد بده
+
+460
+00:44:30,940 --> 00:44:36,040
+يدرس أي موضوع، هو الـ PubMed، الـ PubMed
+
+461
+00:44:36,040 --> 00:44:42,520
+موقع في ولايات المتحدة الأمريكية، ومحطين فيه الـ
+
+462
+00:44:42,520 --> 00:44:51,200
+DNA والـ RNA والبروتين وكذا. ويعني نتذكر يعني من
+
+463
+00:44:51,200 --> 00:44:56,380
+سبب أنه في عندي 64 من الـ Nucleotide Sequence حتى
+
+464
+00:44:56,380 --> 00:45:01,680
+يعمل الـ 20 Amino Acids، لإنه فيه اشتراكات يعني
+
+465
+00:45:01,680 --> 00:45:07,340
+أحيانًا الـ SNPs هذه ما الهاش قيمة، ما هي بتساعدنا أن
+
+466
+00:45:07,340 --> 00:45:12,240
+نشوف من وين أجى هذا الـ DNA، من الأب، من الأم، هل
+
+467
+00:45:12,240 --> 00:45:16,760
+صار فيه تغير معين ولا لأ، أو أنه بس على مستوى الـ
+
+468
+00:45:16,760 --> 00:45:22,200
+Protein، قد لا يكون له قيمة يعني. فهنا مجموعة مراجع
+
+469
+00:45:22,200 --> 00:45:27,960
+حتى الواحد لو طلع إشي يشوف بشبه إيش، حد اكتشفه من
+
+470
+00:45:27,960 --> 00:45:32,340
+قبل، وأحيانًا هذه المراجع مش بس للـ Human Genetic
+
+471
+00:45:32,340 --> 00:45:38,500
+Diversity، في أول Whole-Genome Sequencing كان لذبابة
+
+472
+00:45:38,500 --> 00:45:43,940
+الفاكهة أو لحيوانات أخرى أو للفيروسات والبكتيريا
+
+473
+00:45:43,940 --> 00:45:51,340
+والنباتات وكذا. ففي قواعد بيانات، الـ Databases
+
+474
+00:45:51,340 --> 00:45:56,820
+بيكون فيها كل المعلومات الوراثية لكل المركبات
+
+475
+00:45:56,820 --> 00:46:02,820
+اللي نعرف عنها سواء Human و Non-Human، وبالتالي
+
+476
+00:46:02,820 --> 00:46:07,300
+إحنا لما نيجي نتعامل، أنه أنا والله عندي عائلة
+
+477
+00:46:07,300 --> 00:46:13,600
+مريضة، أخدت الـ DNA منهم، درست شو الترتيب الـ
+
+478
+00:46:13,600 --> 00:46:18,360
+Sequence بتاعتهم فوق الـ PCR، وعرفت الترتيب، ممكن
+
+479
+00:46:18,360 --> 00:46:25,100
+أقارنه بـ Database، يعني لما نقول Diversity
+
+480
+00:46:25,100 --> 00:46:31,720
+و Variation، بنبدأ أنه في أشياء شائعة منهم مثلًا
+
+481
+00:46:31,720 --> 00:46:36,320
+اللي هي SNP اللي هي Single Nucleotide Polymorphism
+
+482
+00:46:36,320 --> 00:46:43,800
+يعني أنه بس حرف واحد على مستوى الـ DNA، وكل ثلاث
+
+483
+00:46:43,800 --> 00:46:48,840
+أحرف بتعطينا Amino Acid واحد. فـ Single Nucleotide
+
+484
+00:46:51,050 --> 00:46:56,530
+و Polymorphism، تغيير بس واحد من الـ Base Pair، وهذا
+
+485
+00:46:56,530 --> 00:47:02,430
+عادةً ممكن ما يكونش له قيمة، بس ممكن يكون عندي ظاهرة
+
+486
+00:47:02,430 --> 00:47:08,370
+أكتر من الـ Base Pair، واحد لحد مية، نسميه Insertion
+
+487
+00:47:08,370 --> 00:47:13,790
+و Deletion. أحيانًا فيه Copy Number Variation، يعني
+
+488
+00:47:13,790 --> 00:47:20,370
+قضية، راح ناخد مثلًا بالهيموفيليا، عبارة عن إذا في
+
+489
+00:47:20,370 --> 00:47:24,910
+هيموفيليا، اللي أخد الثلاسيميا في Alpha و Beta
+
+490
+00:47:24,910 --> 00:47:28,730
+إذا تبعات الـ Alpha هي Copy Number Variation
+
+491
+00:47:28,730 --> 00:47:35,750
+فبتلاقي قطعة كبيرة، أكبر من يعني عشر آلاف Base، عشر
+
+492
+00:47:35,750 --> 00:47:40,710
+آلاف كيلو Base، أو مليون، One Mega Base، أو قضية أنه
+
+493
+00:47:40,710 --> 00:47:46,630
+يصير Inversion، يعني أنه نتيجة لفة الـ DNA، إن حطت
+
+494
+00:47:46,630 --> 00:47:53,060
+بطريقة مختلفة. هي أنواع الـ Variations اللي ممكن مرات
+
+495
+00:47:53,060 --> 00:48:01,440
+تحدث، هي تشبه من اللي حطيناها مرة من قبل، أنه هي
+
+496
+00:48:01,440 --> 00:48:06,920
+عندي Different Sequence في قطعة معينة بشتغل عليها
+
+497
+00:48:06,920 --> 00:48:11,580
+إذا كان زي هيك، هذا الإنسان عنده الأليل الأول
+
+498
+00:48:11,580 --> 00:48:17,830
+والثاني، الأليلين زي بعض، بس في واحد هذا عنده SNPs
+
+499
+00:48:17,830 --> 00:48:24,810
+هاي بدنا نسميها هنا اللي هي deletion أو insertion
+
+500
+00:48:24,810 --> 00:48:32,230
+هنا اللي بنلاحظه، شوفوا هدول، هذا الأليل الأول اللي
+
+501
+00:48:32,230 --> 00:48:35,710
+هو بيشبه الـ reference، اللي صار هنا صار عندي
+
+502
+00:48:35,710 --> 00:48:42,030
+insertion، يعني هاي أجت الزيادة، فالـ T كانت هنا
+
+503
+00:48:42,030 --> 00:48:49,510
+مفروض تجي ورا الـ G ثم A ثم A ثم C ثم T ثم كده
+
+504
+00:48:49,510 --> 00:48:57,770
+فهذا النوع بدنا نسميه Indel، صحيح A، بس هو حقيقة هو
+
+505
+00:48:57,770 --> 00:49:02,650
+insertion single nucleotide، طبعًا هذا بيخرب الدنيا
+
+506
+00:49:02,650 --> 00:49:08,220
+الـ SNP في الغالب ما راح يعمل أي شيء، لأنه يمكن مرات
+
+507
+00:49:08,220 --> 00:49:12,000
+كثيرة أنه بتكون نفس البروتين، بالتالي مش ضروري أن
+
+508
+00:49:12,000 --> 00:49:17,120
+يكون له تأثير، بس أحيانًا طبعًا بيأثر، هنا هذا
+
+509
+00:49:17,120 --> 00:49:23,320
+بيسموه، لما يكون insertion لواحد، راح يخرّب كل الـ
+
+510
+00:49:23,320 --> 00:49:29,080
+copy هذه، راح تكون، لأنه نقرأ ثلاث ثلاث ثلاث، لما تحط
+
+511
+00:49:29,080 --> 00:49:33,840
+واحد زيادة، راح تخرّب الثلاثيات، أما لو صار الـ
+
+512
+00:49:33,840 --> 00:49:37,260
+insertion لثلاثة، ممكن ما يكونش له أي تأثير كبير
+
+513
+00:49:37,260 --> 00:49:41,640
+لأنه بالأخير بيظل البروتين ممكن إنتاجه من هذا الـ
+
+514
+00:49:41,640 --> 00:49:48,240
+DNA، هنا صارت عملية deletion،
+
+515
+00:49:48,240 --> 00:49:52,360
+deletion لإثنين، لما يكون إثنين الـ deleted يعني
+
+516
+00:49:52,360 --> 00:49:57,300
+أنا هنا، هاي تمام زي البقية، هذول الـ T والـ T طال
+
+517
+00:49:57,300 --> 00:50:03,520
+الـ C صارت تشبك ورا الـ T، والبقية بنزل زي ما هو
+
+518
+00:50:04,370 --> 00:50:08,090
+فالأصل كان، يعني عملوا زي هنا الـ Rectare Deletion
+
+519
+00:50:08,090 --> 00:50:13,770
+حطوا هاي ورا هاي على طول، وجرّوا البقية. فهذه أنواع
+
+520
+00:50:13,770 --> 00:50:22,570
+من بعض الـ Polymorphisms اللي بنشوفها في الـ
+
+521
+00:50:22,570 --> 00:50:25,750
+غير
+
+522
+00:50:25,750 --> 00:50:30,050
+الـ SNP، حكينا
+
+523
+00:50:30,050 --> 00:50:36,140
+Single أو Limited، يا إما insertion أو deletion
+
+524
+00:50:36,140 --> 00:50:42,380
+أحيانًا هنا copy number variant، يعني أنا هنا FG
+
+525
+00:50:42,380 --> 00:50:50,740
+مرة واحدة، قطعة FG FG FG، طبعًا هنا يعني على مستوى
+
+526
+00:50:50,740 --> 00:51:02,000
+الجينات كلها، ناشي، يعني أنا بدل الأليل الأول، الـ H
+
+527
+00:51:02,000 --> 00:51:05,860
+هنا، وبعدين G F يعني A B C D E F
+
+528
+00:51:05,860 --> 00:51:12,860
+G، هذا على مستوى الجين كله. فأحيانًا في إنسان غير
+
+529
+00:51:12,860 --> 00:51:18,100
+إنسان ثاني، أنه هنا بيصير ثلاثي copy، بدل ما هي واحد
+
+530
+00:51:18,100 --> 00:51:23,600
+اللي كان لازم تكون. وفي inverse polymorphism، إذا
+
+531
+00:51:23,600 --> 00:51:28,220
+كان عندي مثلًا ترتيب الجينات A B C D E
+
+532
+00:51:28,220 --> 00:51:33,200
+F G H كده، صار قطع ولسف بطريقة غلط، بحيث أنه
+
+533
+00:51:33,200 --> 00:51:39,020
+صار AB بعدين EDC، هنا الله أعلم، يعني ما يكونش
+
+534
+00:51:39,020 --> 00:51:43,780
+تأثير كبير على الوظيفة، بقدر ما أنه على مستوى الـ
+
+535
+00:51:43,780 --> 00:51:47,880
+DNA فيه اختلافات، Polymorphism Micro-satellite
+
+536
+00:51:47,880 --> 00:51:52,680
+polymorphism هي تكرار
+
+537
+00:51:52,680 --> 00:51:56,180
+لمجموعات معينة، و Mobile element insertion
+
+538
+00:51:56,180 --> 00:52:01,540
+polymorphism بيغيّر تفتيح قراءات الـ DNA، وأشياء
+
+539
+00:52:01,540 --> 00:52:06,000
+مختلفة فيه
+
+540
+00:52:06,000 --> 00:52:12,280
+يعني هذه الظواهر، اليوم بنوقف لهاللحظة، أنا آسف
+
+541
+00:52:12,280 --> 00:52:18,660
+اليوم خربطة من عندي، بس إن شاء الله المرة اللي جاية
+
+542
+00:52:18,660 --> 00:52:22,340
+بنراجع الأشياء، وده فيه أسئلة، وجروب الـ WhatsApp
+
+543
+00:52:22,340 --> 00:52:25,480
+فاتح يعني
+
+544
+00:52:27,390 --> 00:52:32,210
+إذا حد عنده أسئلة ممكن نتناقش فيها، يعطيكم العافية
+
+545
+00:52:32,210 --> 00:52:37,270
+السلام عليكم، السلام ورحمة الله، يعطيك العافية، مش
+
+546
+00:52:37,270 --> 00:52:39,770
+عارف إذا دكتورة ده كنت سامعني لأ، لكن عمومًا يعطيك
+
+547
+00:52:39,770 --> 00:52:43,650
+العافية، يعطيكم العافية يا دكاترة، وإن شاء الله يعني
+
+548
+00:52:43,650 --> 00:52:47,270
+إلى لقاء قادم بإذن الله، السلام عليكم، يعطيكم
+
+549
+00:52:47,270 --> 00:52:47,650
+العافية
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/fBzW7egRH9k_raw.json b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/fBzW7egRH9k_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..8b6eddbefd63167b289629c425ebbdf7c2ef1a95
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/fBzW7egRH9k_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 2248, "start": 0.88, "end": 22.48, "text": "الجزء الـ slide هذا بعد ما اتكلمنا كيف الـ DNA شكله وكيف بتم عملية انقسام الخلايا أو نوعين الانقسام بهدف ابقاء عدد الخلايا كما هما اللي هو الـ Mitosis عشان يظل عدد الخلايا زي ما هما", "tokens": [6027, 7435, 11622, 38207, 2423, 39184, 4137, 23758, 39182, 19446, 1975, 2655, 4117, 19528, 8315, 9122, 33911, 2423, 39184, 8272, 13412, 28820, 3224, 4032, 4117, 33911, 4724, 39237, 6225, 42213, 10632, 16472, 4587, 3794, 10943, 33962, 15040, 25528, 34051, 8717, 45367, 9957, 2423, 7649, 4587, 3794, 10943, 39627, 3215, 5172, 48127, 4587, 16606, 6225, 3215, 3215, 33962, 15040, 25528, 9122, 15042, 8032, 15042, 13672, 1829, 31439, 2423, 39184, 10821, 8211, 6225, 8592, 7649, 7251, 19913, 1211, 6225, 3215, 3215, 33962, 15040, 25528, 30767, 1829, 19446, 8032, 15042], "avg_logprob": -0.13947087340056896, "compression_ratio": 1.752808988764045, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 0.88, "end": 1.32, "word": "الجزء", "probability": 0.905517578125}, {"start": 1.32, "end": 1.54, "word": " الـ", "probability": 0.518798828125}, {"start": 1.54, "end": 2.82, "word": " slide", "probability": 0.56640625}, {"start": 2.82, "end": 3.12, "word": " هذا", "probability": 0.857421875}, {"start": 3.12, "end": 3.34, "word": " بعد", "probability": 0.93994140625}, {"start": 3.34, "end": 3.46, "word": " ما", "probability": 0.89697265625}, {"start": 3.46, "end": 4.16, "word": " اتكلمنا", "probability": 0.899609375}, {"start": 4.16, "end": 4.92, "word": " كيف", "probability": 0.927001953125}, {"start": 4.92, "end": 5.24, "word": " الـ", "probability": 0.884521484375}, {"start": 5.24, "end": 5.64, "word": " DNA", "probability": 0.9150390625}, {"start": 5.64, "end": 6.78, "word": " شكله", "probability": 0.9847005208333334}, {"start": 6.78, "end": 7.18, "word": " وكيف", "probability": 0.77734375}, {"start": 7.18, "end": 7.62, "word": " بتم", "probability": 0.5242919921875}, {"start": 7.62, "end": 8.42, 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0.9334309895833334}, {"start": 250.36, "end": 251.38, "word": " و", "probability": 0.455810546875}, {"start": 251.38, "end": 252.08, "word": " الـ", "probability": 0.58587646484375}, {"start": 252.08, "end": 252.88, "word": " Bases", "probability": 0.633056640625}, {"start": 252.88, "end": 253.42, "word": " أو", "probability": 0.921875}, {"start": 253.42, "end": 254.02, "word": " الـ", "probability": 0.940185546875}, {"start": 254.02, "end": 254.9, "word": " Nitrogenous", "probability": 0.7307942708333334}, {"start": 254.9, "end": 255.36, "word": " Bases", "probability": 0.700927734375}, {"start": 255.36, "end": 255.86, "word": " تبعات", "probability": 0.9178466796875}, {"start": 255.86, "end": 256.02, "word": " الـ", "probability": 0.853759765625}, {"start": 256.02, "end": 256.84, "word": " Nucleotides", "probability": 0.93857421875}, {"start": 256.84, "end": 257.92, "word": " فمن", "probability": 0.937255859375}, {"start": 257.92, "end": 258.36, "word": " تركيب", "probability": 0.9608154296875}, {"start": 258.36, "end": 258.64, "word": " الـ", "probability": 0.969482421875}, {"start": 258.64, "end": 259.02, "word": " DNA", "probability": 0.94189453125}, {"start": 259.02, "end": 259.78, "word": " بنحوله", "probability": 0.9266357421875}, {"start": 259.78, "end": 260.68, "word": " لتركيب", "probability": 0.9390625}, {"start": 260.68, "end": 261.0, "word": " أو", "probability": 0.96142578125}, {"start": 261.0, "end": 261.86, "word": " ترتيب", "probability": 0.910888671875}, {"start": 261.86, "end": 262.44, "word": " الـ", "probability": 0.97900390625}, {"start": 262.44, "end": 262.86, "word": " Amino", "probability": 0.908447265625}, {"start": 262.86, "end": 263.24, "word": " Acids", "probability": 0.848876953125}, {"start": 263.24, "end": 264.4, "word": " فلو", "probability": 0.9680989583333334}, {"start": 264.4, "end": 264.84, "word": " كان", "probability": 0.99658203125}, {"start": 264.84, "end": 265.6, "word": " اللي", "probability": 0.867431640625}, {"start": 265.6, "end": 266.24, "word": " اكتشفوه", "probability": 0.9103655133928571}, {"start": 266.24, "end": 266.86, "word": " العلماء", "probability": 0.990234375}, {"start": 266.86, "end": 267.8, "word": " أنه", "probability": 0.6939697265625}, {"start": 267.8, "end": 268.0, "word": " لو", "probability": 0.98046875}, {"start": 268.0, "end": 268.46, "word": " كان", "probability": 0.99755859375}, {"start": 268.46, "end": 269.3, "word": " الأمر", "probability": 0.947998046875}, {"start": 269.3, "end": 271.3, "word": " بيكون", "probability": 0.7853190104166666}, {"start": 271.3, "end": 272.02, "word": " من", "probability": 0.994140625}, {"start": 272.02, "end": 272.7, "word": " خلال", "probability": 0.99755859375}, {"start": 272.7, "end": 274.4, "word": " Single", "probability": 0.86474609375}, {"start": 274.4, "end": 276.76, "word": " Nucleotide", "probability": 0.8279052734375}], "temperature": 1.0}, {"id": 11, "seek": 29087, "start": 278.39, "end": 290.87, "text": "كان نقدر نعمل شفرة لـ 4 amino acids لو كان عندي Two Nucleotides بيثيروا هم اللي بيعملوا الـ", "tokens": [41361, 8717, 28543, 2288, 8717, 25957, 1211, 13412, 5172, 25720, 5296, 39184, 1017, 24674, 21667, 45164, 25961, 18871, 16254, 4453, 426, 1311, 306, 310, 1875, 4724, 1829, 12984, 13546, 14407, 8032, 2304, 13672, 1829, 4724, 1829, 25957, 1211, 14407, 2423, 39184], "avg_logprob": -0.3145461437248048, "compression_ratio": 1.1570247933884297, "no_speech_prob": 0.0, "words": [{"start": 278.39, "end": 278.69, "word": "كان", "probability": 0.73193359375}, {"start": 278.69, "end": 279.15, "word": " نقدر", "probability": 0.8369140625}, {"start": 279.15, "end": 280.73, "word": " نعمل", "probability": 0.9747721354166666}, {"start": 280.73, "end": 281.19, "word": " شفرة", "probability": 0.9381510416666666}, {"start": 281.19, "end": 281.47, "word": " لـ", "probability": 0.791015625}, {"start": 281.47, "end": 281.79, "word": " 4", "probability": 0.638671875}, {"start": 281.79, "end": 282.65, "word": " amino", "probability": 0.0736083984375}, {"start": 282.65, "end": 283.07, "word": " acids", "probability": 0.58056640625}, {"start": 283.07, "end": 284.23, "word": " لو", "probability": 0.56298828125}, {"start": 284.23, "end": 284.65, "word": " كان", "probability": 0.97802734375}, {"start": 284.65, "end": 285.41, "word": " عندي", "probability": 0.722412109375}, {"start": 285.41, "end": 285.89, "word": " Two", "probability": 0.381103515625}, {"start": 285.89, "end": 286.87, "word": " Nucleotides", "probability": 0.79560546875}, {"start": 286.87, "end": 287.57, "word": " بيثيروا", "probability": 0.76337890625}, {"start": 287.57, "end": 287.95, "word": " هم", "probability": 0.7578125}, {"start": 287.95, "end": 288.77, "word": " اللي", "probability": 0.979248046875}, {"start": 288.77, "end": 290.01, "word": " بيعملوا", "probability": 0.94111328125}, {"start": 290.01, "end": 290.87, "word": " الـ", "probability": 0.703369140625}], "temperature": 1.0}, {"id": 12, "seek": 32342, "start": 295.7, "end": 323.42, "text": "الـ Coding أو التشفير أنه Two Amino Acids فالأول أربعة فينا واحد من أربع احتمالات والثاني أربع احتمالات ثانية ففي الحالة دي راح يكون ستاشر Nucleus ستاشر Amino Acids نقدر نرمز إليهم فثبت إنه لأ هم ثلاثة كل ثلاثة بنقروا مع بعض وكل ثلاثة مع بعض برمزوا ل Amino Acid واحد", "tokens": [6027, 39184, 383, 8616, 34051, 16712, 8592, 5172, 13546, 14739, 3224, 4453, 2012, 2982, 5097, 3742, 6156, 6027, 10721, 12610, 5551, 25513, 27884, 6156, 1829, 8315, 36764, 24401, 9154, 5551, 25513, 3615, 1975, 33753, 2304, 6027, 9307, 16070, 12984, 7649, 1829, 5551, 25513, 3615, 1975, 33753, 2304, 6027, 9307, 38637, 7649, 10632, 6156, 41185, 21542, 6027, 3660, 11778, 1829, 12602, 39319, 7251, 30544, 8608, 2655, 33599, 2288, 13612, 2160, 301, 8608, 2655, 33599, 2288, 2012, 2982, 5097, 3742, 8717, 28543, 2288, 8717, 2288, 2304, 11622, 11933, 20292, 16095, 6156, 12984, 3555, 2655, 36145, 3224, 5296, 10721, 8032, 2304, 38637, 1211, 5718, 104, 3660, 28242, 38637, 1211, 5718, 104, 3660, 44945, 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فالأول", "probability": 0.8702392578125}, {"start": 301.54, "end": 302.16, "word": " أربعة", "probability": 0.9638671875}, {"start": 302.16, "end": 302.78, "word": " فينا", "probability": 0.2637125651041667}, {"start": 302.78, "end": 303.24, "word": " واحد", "probability": 0.965087890625}, {"start": 303.24, "end": 303.4, "word": " من", "probability": 0.9921875}, {"start": 303.4, "end": 303.74, "word": " أربع", "probability": 0.726318359375}, {"start": 303.74, "end": 304.46, "word": " احتمالات", "probability": 0.94404296875}, {"start": 304.46, "end": 305.0, "word": " والثاني", "probability": 0.86083984375}, {"start": 305.0, "end": 305.38, "word": " أربع", "probability": 0.9060872395833334}, {"start": 305.38, "end": 305.96, "word": " احتمالات", "probability": 0.986328125}, {"start": 305.96, "end": 306.48, "word": " ثانية", "probability": 0.9783528645833334}, {"start": 306.48, "end": 307.16, "word": " ففي", "probability": 0.9521484375}, {"start": 307.16, "end": 307.52, "word": " الحالة", 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"probability": 0.9669189453125}, {"start": 315.2, "end": 315.56, "word": " إنه", "probability": 0.688232421875}, {"start": 315.56, "end": 315.82, "word": " لأ", "probability": 0.985107421875}, {"start": 315.82, "end": 316.2, "word": " هم", "probability": 0.708740234375}, {"start": 316.2, "end": 316.92, "word": " ثلاثة", "probability": 0.9416015625}, {"start": 316.92, "end": 317.24, "word": " كل", "probability": 0.72900390625}, {"start": 317.24, "end": 317.76, "word": " ثلاثة", "probability": 0.9802734375}, {"start": 317.76, "end": 318.18, "word": " بنقروا", "probability": 0.9014892578125}, {"start": 318.18, "end": 318.32, "word": " مع", "probability": 0.99462890625}, {"start": 318.32, "end": 318.76, "word": " بعض", "probability": 0.996826171875}, {"start": 318.76, "end": 319.86, "word": " وكل", "probability": 0.913818359375}, {"start": 319.86, "end": 320.4, "word": " ثلاثة", "probability": 0.98125}, {"start": 320.4, "end": 320.56, "word": " مع", "probability": 0.986328125}, {"start": 320.56, "end": 320.96, "word": " بعض", "probability": 0.99658203125}, {"start": 320.96, "end": 321.74, "word": " برمزوا", "probability": 0.9080078125}, {"start": 321.74, "end": 322.12, "word": " ل", "probability": 0.8134765625}, {"start": 322.12, "end": 322.72, "word": " Amino", "probability": 0.6156005859375}, {"start": 322.72, "end": 323.04, "word": " Acid", "probability": 0.840576171875}, {"start": 323.04, "end": 323.42, "word": " واحد", "probability": 0.841552734375}], "temperature": 1.0}, {"id": 13, "seek": 34796, "start": 323.9, "end": 347.96, "text": "فعشان هيك بنسميهم Codon أو Triplet أو كده عبارة عن ثلاث من الـ Nucleotides حتى يرمزوا لواحد من الـ Amino Acid طبعاً أربعة بأربعة بأربعة بتصير أربعة و ستين فالأربعة و ستين زيادة عن الأشرين Amino Acid بس بتغطيهم و راح نشوف كيف الأمور تتطور", "tokens": [5172, 3615, 8592, 7649, 39896, 4117, 44945, 38251, 1829, 16095, 383, 378, 266, 34051, 33141, 2631, 34051, 9122, 3215, 3224, 6225, 3555, 9640, 3660, 18871, 38637, 1211, 5718, 104, 9154, 2423, 39184, 426, 1311, 306, 310, 1875, 11331, 49975, 7251, 2288, 2304, 11622, 14407, 5296, 14407, 24401, 9154, 2423, 39184, 2012, 2982, 5097, 327, 23032, 3555, 3615, 995, 14111, 5551, 25513, 27884, 4724, 10721, 25513, 27884, 4724, 10721, 25513, 27884, 39894, 9381, 13546, 5551, 25513, 27884, 4032, 8608, 2655, 9957, 6156, 6027, 10721, 25513, 27884, 4032, 8608, 2655, 9957, 30767, 1829, 18513, 3660, 18871, 16247, 46309, 9957, 2012, 2982, 5097, 327, 4724, 3794, 39894, 17082, 9566, 1829, 16095, 4032, 12602, 39319, 8717, 8592, 38688, 9122, 33911, 16247, 2304, 13063, 6055, 2655, 9566, 13063], "avg_logprob": -0.17162298278943186, "compression_ratio": 1.7136563876651982, "no_speech_prob": 2.980232238769531e-07, "words": [{"start": 323.9, "end": 324.46, "word": "فعشان", "probability": 0.7803955078125}, {"start": 324.46, "end": 324.78, "word": " هيك", "probability": 0.976806640625}, {"start": 324.78, "end": 325.48, "word": " بنسميهم", "probability": 0.84466552734375}, {"start": 325.48, "end": 326.06, "word": " Codon", "probability": 0.7142333984375}, {"start": 326.06, "end": 326.28, "word": " أو", "probability": 0.97119140625}, {"start": 326.28, "end": 327.04, "word": " Triplet", "probability": 0.566162109375}, {"start": 327.04, "end": 327.3, "word": " أو", "probability": 0.97216796875}, {"start": 327.3, "end": 327.82, "word": " كده", "probability": 0.884765625}, {"start": 327.82, "end": 328.54, "word": " عبارة", "probability": 0.9664306640625}, {"start": 328.54, "end": 328.82, "word": " عن", "probability": 0.9970703125}, {"start": 328.82, "end": 329.36, "word": " ثلاث", "probability": 0.8741455078125}, {"start": 329.36, "end": 329.78, "word": " من", "probability": 0.904296875}, {"start": 329.78, "end": 330.24, "word": " الـ", "probability": 0.945068359375}, {"start": 330.24, "end": 331.42, "word": " Nucleotides", "probability": 0.86181640625}, {"start": 331.42, "end": 331.88, "word": " حتى", "probability": 0.909423828125}, {"start": 331.88, "end": 332.5, "word": " يرمزوا", "probability": 0.96533203125}, {"start": 332.5, "end": 333.22, "word": " لواحد", "probability": 0.81787109375}, {"start": 333.22, "end": 333.78, "word": " من", "probability": 0.99462890625}, {"start": 333.78, "end": 334.2, "word": " الـ", "probability": 0.97314453125}, {"start": 334.2, "end": 334.6, "word": " Amino", "probability": 0.879638671875}, {"start": 334.6, "end": 334.96, "word": " Acid", "probability": 0.636962890625}, {"start": 334.96, "end": 336.34, "word": " طبعاً", "probability": 0.9119140625}, {"start": 336.34, "end": 336.72, "word": " أربعة", "probability": 0.8328450520833334}, {"start": 336.72, "end": 337.14, "word": " بأربعة", "probability": 0.93115234375}, {"start": 337.14, "end": 337.58, "word": " بأربعة", "probability": 0.9501953125}, {"start": 337.58, "end": 337.98, "word": " بتصير", "probability": 0.8486328125}, {"start": 337.98, "end": 338.36, "word": " أربعة", "probability": 0.85888671875}, {"start": 338.36, "end": 338.46, "word": " و", "probability": 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Translation في اللوم وفي أحيانًا بيكون عندى ظواهر اللي يسمونه «allelic imbalance» يعني هنا الغالبين العظمى جاي من هنا بس هداك موجود بس كمية قليلة فالـ Snaps", "tokens": [5172, 2304, 12984, 1211, 14111, 995, 34105, 8978, 43242, 7578, 44945, 38251, 1829, 3224, 4657, 3317, 78, 12, 336, 338, 299, 6114, 5933, 37037, 8315, 4657, 40251, 6114, 5933, 37495, 22653, 16247, 12984, 1863, 9957, 4724, 1829, 8592, 2655, 31747, 14407, 14739, 3224, 7251, 9381, 13546, 6225, 42213, 10632, 2423, 39184, 6531, 12432, 4032, 3555, 22488, 9957, 6531, 24278, 8978, 13672, 20498, 4032, 41185, 5551, 5016, 1829, 7649, 14111, 995, 4724, 1829, 30544, 43242, 7578, 1357, 116, 14407, 3224, 2288, 13672, 1829, 7251, 38251, 11536, 3224, 4657, 336, 338, 299, 43007, 5933, 37495, 22653, 34105, 6024, 118, 6027, 3555, 9957, 18863, 19913, 2304, 7578, 10874, 47302, 9154, 34105, 4724, 3794, 8032, 28259, 4117, 3714, 29245, 23328, 4724, 3794, 9122, 2304, 10632, 12174, 20292, 37977, 6156, 6027, 39184, 9264, 2382], "avg_logprob": 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" فالـ", "probability": 0.9285481770833334}, {"start": 1533.86, "end": 1535.12, "word": " Snaps", "probability": 0.5712890625}], "temperature": 1.0}, {"id": 57, "seek": 156304, "start": 1535.34, "end": 1563.04, "text": "اللي موجودة في الـ RNA مش عارف ليش حطوا هاي الـ SNP بالذات اللي هي Single Nucleotide Polymorphism يعني الـ SNP هدولة هما القاليه اللي استخدمناهم عشان نعرف أن هاي أجت من هذا وهنا أجن بالنص من هنا وهنا يعني الـ SNP هو Single Nucleotide Polymorphism راح نحكي عنه بعد شوية فمن خلاله بقدر أعرف أني نسخة", "tokens": [6027, 20292, 3714, 29245, 23328, 3660, 8978, 2423, 39184, 22484, 37893, 6225, 9640, 5172, 32239, 8592, 11331, 9566, 14407, 8032, 47302, 2423, 39184, 13955, 47, 20666, 8848, 9307, 13672, 1829, 39896, 31248, 426, 1311, 306, 310, 482, 18553, 76, 18191, 1434, 37495, 22653, 2423, 39184, 13955, 47, 8032, 3215, 12610, 3660, 8032, 15042, 25062, 6027, 1829, 3224, 13672, 1829, 44713, 9778, 40448, 8315, 16095, 6225, 8592, 7649, 8717, 3615, 28480, 14739, 8032, 47302, 5551, 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"word": " SNP", "probability": 0.910888671875}, {"start": 1554.56, "end": 1555.06, "word": " هو", "probability": 0.978515625}, {"start": 1555.06, "end": 1556.18, "word": " Single", "probability": 0.8994140625}, {"start": 1556.18, "end": 1557.02, "word": " Nucleotide", "probability": 0.9787109375}, {"start": 1557.02, "end": 1557.78, "word": " Polymorphism", "probability": 0.90234375}, {"start": 1557.78, "end": 1558.02, "word": " راح", "probability": 0.8857421875}, {"start": 1558.02, "end": 1558.36, "word": " نحكي", "probability": 0.98876953125}, {"start": 1558.36, "end": 1558.58, "word": " عنه", "probability": 0.9892578125}, {"start": 1558.58, "end": 1558.8, "word": " بعد", "probability": 0.83935546875}, {"start": 1558.8, "end": 1559.3, "word": " شوية", "probability": 0.830078125}, {"start": 1559.3, "end": 1560.46, "word": " فمن", "probability": 0.883056640625}, {"start": 1560.46, "end": 1560.92, "word": " خلاله", "probability": 0.991455078125}, {"start": 1560.92, "end": 1561.36, "word": " بقدر", "probability": 0.8966471354166666}, {"start": 1561.36, "end": 1561.78, "word": " أعرف", "probability": 0.900390625}, {"start": 1561.78, "end": 1562.34, "word": " أني", "probability": 0.679443359375}, {"start": 1562.34, "end": 1563.04, "word": " نسخة", "probability": 0.9720458984375}], "temperature": 1.0}, {"id": 58, "seek": 159132, "start": 1563.42, "end": 1591.32, "text": "الـ DNA اللي تم الـ Transcription تبعها بحيث أنه أعطاني الـ RNA هذا فالفكرة هنا أنه صحيح أنا عند جينين أو نسختين من الـ Chromosomes ونسختين من الجينات وكذا بس مش دايماً أنه أثنين لازم أثنين يشتغلوا أحياناً", "tokens": [6027, 39184, 8272, 13672, 1829, 46811, 2423, 39184, 6531, 12432, 6055, 3555, 3615, 11296, 4724, 5016, 1829, 12984, 14739, 3224, 5551, 3615, 9566, 7649, 1829, 2423, 39184, 22484, 23758, 6156, 6027, 5172, 4117, 25720, 34105, 14739, 3224, 20328, 5016, 1829, 5016, 41850, 43242, 10874, 9957, 9957, 34051, 8717, 3794, 46456, 9957, 9154, 2423, 39184, 1721, 40934, 18168, 4032, 1863, 3794, 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{"start": 1696.13, "end": 1696.51, "word": " أدرس", "probability": 0.99267578125}, {"start": 1696.51, "end": 1696.73, "word": " هذا", "probability": 0.98828125}, {"start": 1696.73, "end": 1697.45, "word": " الموضوع", "probability": 0.998291015625}, {"start": 1697.45, "end": 1699.01, "word": " ماشي", "probability": 0.7520345052083334}], "temperature": 1.0}, {"id": 63, "seek": 172664, "start": 1700.32, "end": 1726.64, "text": "بلاقي إن أنا عندي أكثر من احتمال في حالات بتلاقي هذا الـ chromosome مثلا نفترض هذا الـ chromosome اللي وردته من أبوي وكان في الجانب الإفلاني يعني مثلا ناخد نفترض مثلا افتراض اللي هو مثلا الـ ABO blood group راح تلاقي إن هنا الموقع تبع الـ ABO blood group", "tokens": [3555, 15040, 38436, 36145, 41850, 18871, 16254, 5551, 4117, 49115, 9154, 1975, 33753, 2304, 6027, 8978, 11331, 6027, 9307, 39894, 15040, 38436, 23758, 2423, 39184, 42896, 50113, 15040, 8717, 5172, 2655, 43042, 23758, 2423, 39184, 42896, 13672, 1829, 4032, 2288, 3215, 47395, 9154, 5551, 3555, 45865, 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0.8203125}, {"start": 1716.16, "end": 1716.7, "word": " مثلا", "probability": 0.96728515625}, {"start": 1716.7, "end": 1717.42, "word": " افتراض", "probability": 0.7669921875}, {"start": 1717.42, "end": 1718.0, "word": " اللي", "probability": 0.970703125}, {"start": 1718.0, "end": 1718.22, "word": " هو", "probability": 0.98828125}, {"start": 1718.22, "end": 1718.66, "word": " مثلا", "probability": 0.968017578125}, {"start": 1718.66, "end": 1718.98, "word": " الـ", "probability": 0.972900390625}, {"start": 1718.98, "end": 1719.42, "word": " ABO", "probability": 0.78515625}, {"start": 1719.42, "end": 1719.7, "word": " blood", "probability": 0.66259765625}, {"start": 1719.7, "end": 1720.72, "word": " group", "probability": 0.94189453125}, {"start": 1720.72, "end": 1721.56, "word": " راح", "probability": 0.6436767578125}, {"start": 1721.56, "end": 1722.1, "word": " تلاقي", "probability": 0.9415690104166666}, {"start": 1722.1, "end": 1722.46, "word": " إن", "probability": 0.72998046875}, {"start": 1722.46, "end": 1722.78, "word": " هنا", "probability": 0.58544921875}, {"start": 1722.78, "end": 1723.52, "word": " الموقع", "probability": 0.9397786458333334}, {"start": 1723.52, "end": 1724.2, "word": " تبع", "probability": 0.9430338541666666}, {"start": 1724.2, "end": 1725.44, "word": " الـ", "probability": 0.985107421875}, {"start": 1725.44, "end": 1725.9, "word": " ABO", "probability": 0.8876953125}, {"start": 1725.9, "end": 1726.24, "word": " blood", "probability": 0.9619140625}, {"start": 1726.24, "end": 1726.64, "word": " group", "probability": 0.97705078125}], "temperature": 1.0}, {"id": 64, "seek": 174788, "start": 1727.26, "end": 1747.88, "text": "وهذا الـ «جينات» الـ «جين» المسؤول عن هذه الخاصية أو هذه الـ Blood Group فاللي راح ألاقيه بالأخير هو أن أنا شايف الـ Protein الـ Protein من أين بدي ييجي؟ بدي ييجي من الـ RNA وبعدين بيعطيني الـ Protein", "tokens": [2407, 3224, 15730, 2423, 39184, 4657, 7435, 1829, 8315, 2655, 5933, 2423, 39184, 4657, 7435, 9957, 5933, 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"probability": 0.8839111328125}, {"start": 1729.22, "end": 1730.5, "word": " المسؤول", "probability": 0.8560791015625}, {"start": 1730.5, "end": 1730.88, "word": " عن", "probability": 0.85791015625}, {"start": 1730.88, "end": 1731.46, "word": " هذه", "probability": 0.9013671875}, {"start": 1731.46, "end": 1733.36, "word": " الخاصية", "probability": 0.9464518229166666}, {"start": 1733.36, "end": 1733.68, "word": " أو", "probability": 0.9375}, {"start": 1733.68, "end": 1734.14, "word": " هذه", "probability": 0.17724609375}, {"start": 1734.14, "end": 1734.34, "word": " الـ", "probability": 0.857666015625}, {"start": 1734.34, "end": 1734.8, "word": " Blood", "probability": 0.405517578125}, {"start": 1734.8, "end": 1735.24, "word": " Group", "probability": 0.607421875}, {"start": 1735.24, "end": 1737.18, "word": " فاللي", "probability": 0.8894856770833334}, {"start": 1737.18, "end": 1737.38, "word": " راح", "probability": 0.9580078125}, {"start": 1737.38, "end": 1737.84, "word": " ألاقيه", "probability": 0.78924560546875}, {"start": 1737.84, "end": 1738.46, "word": " بالأخير", "probability": 0.8746337890625}, {"start": 1738.46, "end": 1739.32, "word": " هو", "probability": 0.09979248046875}, {"start": 1739.32, "end": 1739.42, "word": " أن", "probability": 0.65625}, {"start": 1739.42, "end": 1739.62, "word": " أنا", "probability": 0.79296875}, {"start": 1739.62, "end": 1739.98, "word": " شايف", "probability": 0.9820963541666666}, {"start": 1739.98, "end": 1740.2, "word": " الـ", "probability": 0.83544921875}, {"start": 1740.2, "end": 1740.66, "word": " Protein", "probability": 0.73486328125}, {"start": 1740.66, "end": 1741.78, "word": " الـ", "probability": 0.852294921875}, {"start": 1741.78, "end": 1742.14, "word": " Protein", "probability": 0.907470703125}, {"start": 1742.14, "end": 1742.3, "word": " من", "probability": 0.9658203125}, {"start": 1742.3, "end": 1742.46, "word": " أين", "probability": 0.910400390625}, {"start": 1742.46, "end": 1742.78, "word": " بدي", 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مستوى شو صار للـ RNA يعني لسه ماكملت أني أشوف شو هو الـ Protein وقفت التفاعل ووقفت الوضع المرحلة المعينة ففي حالة الـ ABO System ماشي إذا واحد مثلا أخد كروموزوم وعليه موقع TA من أبوه", "tokens": [1211, 2407, 41850, 34105, 8978, 27188, 2655, 5016, 3660, 29538, 20666, 11242, 3555, 9566, 41850, 47525, 2288, 3794, 15844, 3714, 14851, 2407, 7578, 13412, 2407, 20328, 9640, 24976, 39184, 22484, 37495, 22653, 5296, 3794, 3224, 19446, 24793, 1211, 2655, 14739, 1829, 5551, 8592, 38688, 13412, 2407, 31439, 2423, 39184, 43371, 259, 4032, 4587, 5172, 2655, 16712, 5172, 995, 30241, 4032, 30543, 5172, 2655, 2423, 2407, 11242, 3615, 9673, 2288, 5016, 37977, 9673, 3615, 9957, 3660, 6156, 41185, 11331, 6027, 3660, 2423, 39184, 13838, 46, 8910, 3714, 33599, 1829, 11933, 15730, 36764, 24401, 50113, 15040, 5551, 9778, 3215, 9122, 2288, 20498, 2407, 11622, 20498, 4032, 3615, 20292, 3224, 3714, 30543, 3615, 20094, 9154, 5551, 3555, 2407, 3224], "avg_logprob": -0.16359508343231985, "compression_ratio": 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" عنها", "probability": 0.9931640625}, {"start": 2759.12, "end": 2759.88, "word": " سواء", "probability": 0.7784830729166666}, {"start": 2759.88, "end": 2760.4, "word": " Human", "probability": 0.6630859375}, {"start": 2760.4, "end": 2760.84, "word": " وNon", "probability": 0.68994140625}, {"start": 2760.84, "end": 2761.3, "word": "-Human", "probability": 0.9288736979166666}, {"start": 2761.3, "end": 2762.36, "word": " وبالتالت", "probability": 0.728564453125}], "temperature": 1.0}, {"id": 102, "seek": 278050, "start": 2762.54, "end": 2780.5, "text": "بس إحنا لما نيجي نتعامل إنه أنا والله عندى عائلة مريضة أخدت الـ DNA منهم درست شو الترتيب الـ Sequence سبعتهم فوق الـ PCR وعرفت الترتيب ممكن أقارنه بـ Database يعني", "tokens": [3555, 3794, 11933, 5016, 8315, 5296, 15042, 8717, 1829, 7435, 1829, 8717, 2655, 3615, 10943, 1211, 36145, 3224, 41850, 16070, 43761, 43242, 7578, 6225, 16373, 37977, 3714, 16572, 11242, 3660, 5551, 9778, 3215, 2655, 2423, 39184, 8272, 9154, 16095, 11778, 2288, 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103, "seek": 280884, "start": 2782.9, "end": 2808.84, "text": "لما نقول Diversity وVariation بنبدأ بإنه في أشياء شائعة منهم مثلًا اللي هي SNP اللي هي Single Nucleotide Polymorphism يعني إنه بس حرف واحد على مستوى الـ DNA وكل ثلاث أحرف تعطينا أمينو أسد واحد فـ Single Nucleotide", "tokens": [1211, 15042, 8717, 39648, 44187, 4032, 53, 3504, 399, 44945, 44510, 10721, 4724, 28814, 1863, 3224, 8978, 5551, 8592, 1829, 16606, 13412, 16373, 27884, 9154, 16095, 50113, 1211, 14111, 995, 13672, 1829, 39896, 13955, 47, 13672, 1829, 39896, 31248, 426, 1311, 306, 310, 482, 18553, 76, 18191, 1434, 37495, 22653, 36145, 3224, 4724, 3794, 11331, 28480, 36764, 24401, 15844, 3714, 14851, 2407, 7578, 2423, 39184, 8272, 4032, 28820, 38637, 1211, 5718, 104, 5551, 5016, 28480, 6055, 3615, 9566, 1829, 8315, 5551, 2304, 9957, 2407, 5551, 3794, 3215, 36764, 24401, 6156, 39184, 31248, 426, 1311, 306, 310, 482], "avg_logprob": -0.18574617255707176, "compression_ratio": 1.4266666666666667, "no_speech_prob": 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"probability": 0.72119140625}, {"start": 3097.28, "end": 3097.6, "word": " عليه", "probability": 0.6827392578125}, {"start": 3097.6, "end": 3097.96, "word": " يعلم", "probability": 0.6212158203125}, {"start": 3097.96, "end": 3098.3, "word": " يعني", "probability": 0.802001953125}, {"start": 3098.3, "end": 3099.02, "word": " مايكونش", "probability": 0.74517822265625}, {"start": 3099.02, "end": 3099.6, "word": " تأثير", "probability": 0.989990234375}, {"start": 3099.6, "end": 3100.8, "word": " كبير", "probability": 0.9894205729166666}, {"start": 3100.8, "end": 3100.96, "word": " على", "probability": 0.62890625}, {"start": 3100.96, "end": 3101.52, "word": " الوظيفة", "probability": 0.9865234375}, {"start": 3101.52, "end": 3102.0, "word": " بقدر", "probability": 0.93701171875}, {"start": 3102.0, "end": 3102.2, "word": " ما", "probability": 0.97802734375}, {"start": 3102.2, "end": 3102.66, "word": " أنه", "probability": 0.78515625}, {"start": 3102.66, "end": 3103.1, "word": " على", "probability": 0.873046875}, {"start": 3103.1, "end": 3103.54, "word": " مستوى", "probability": 0.975341796875}, {"start": 3103.54, "end": 3103.78, "word": " الـ", "probability": 0.953369140625}, {"start": 3103.78, "end": 3103.92, "word": " DNA", "probability": 0.67041015625}, {"start": 3103.92, "end": 3104.28, "word": " فيه", "probability": 0.826416015625}, {"start": 3104.28, "end": 3105.26, "word": " اختلافات،", "probability": 0.8299153645833334}, {"start": 3105.26, "end": 3106.02, "word": " Polymorphism", "probability": 0.90966796875}, {"start": 3106.02, "end": 3107.12, "word": " Micro", "probability": 0.6328125}, {"start": 3107.12, "end": 3107.88, "word": "-satellite", "probability": 0.8153076171875}, {"start": 3107.88, "end": 3108.92, "word": " polymorphism", "probability": 0.881591796875}, {"start": 3108.92, "end": 3109.54, "word": " هي", "probability": 0.464599609375}, {"start": 3109.54, "end": 3112.68, "word": " تكرار", "probability": 0.96044921875}, {"start": 3112.68, "end": 3113.64, "word": " لمجموعات", "probability": 0.97548828125}, {"start": 3113.64, "end": 3114.4, "word": " معينة", "probability": 0.9934895833333334}, {"start": 3114.4, "end": 3114.96, "word": " وMobile", "probability": 0.604248046875}, {"start": 3114.96, "end": 3115.5, "word": " element", "probability": 0.35595703125}, {"start": 3115.5, "end": 3116.18, "word": " insertion", "probability": 0.975341796875}, {"start": 3116.18, "end": 3117.08, "word": " polymorphism", "probability": 0.9066162109375}], "temperature": 1.0}, {"id": 115, "seek": 314548, "start": 3117.52, "end": 3145.48, "text": "بغيّر تفتيح خيفقرات الـ DNA وأشياء مختلفة فيه يعني هذه الظواهر اليوم بنوقف لهذه اللحظة أنا آسف اليوم خربطة من عندي بس إن شاء الله المرة اللي جاي بنراجع الأشياء وده فيه أسئلة وجروب الـ WhatsApp فاتحة يعني", "tokens": [3555, 17082, 1829, 11703, 2288, 6055, 5172, 31371, 5016, 16490, 1829, 5172, 4587, 2288, 9307, 2423, 39184, 8272, 4032, 10721, 8592, 1829, 16606, 3714, 46456, 46538, 3660, 8978, 3224, 37495, 22653, 29538, 6024, 116, 14407, 3224, 2288, 45595, 20498, 44945, 30543, 5172, 46740, 24192, 13672, 5016, 19913, 3660, 41850, 19753, 3794, 5172, 45595, 20498, 16490, 25513, 9566, 3660, 9154, 18871, 16254, 4724, 3794, 36145, 13412, 16606, 21984, 9673, 25720, 13672, 1829, 10874, 47302, 44945, 2288, 26108, 3615, 16247, 8592, 1829, 16606, 4032, 3215, 3224, 8978, 3224, 5551, 3794, 19986, 37977, 4032, 7435, 32887, 3555, 2423, 39184, 30513, 6156, 9307, 5016, 3660, 37495, 22653], "avg_logprob": -0.24594350732289827, "compression_ratio": 1.6497695852534562, "no_speech_prob": 4.76837158203125e-07, "words": [{"start": 3117.52, "end": 3118.36, "word": "بغيّر", "probability": 0.728759765625}, {"start": 3118.36, "end": 3118.9, "word": " تفتيح", "probability": 0.67303466796875}, {"start": 3118.9, "end": 3119.62, "word": " خيفقرات", "probability": 0.66876220703125}, {"start": 3119.62, "end": 3119.86, "word": " الـ", "probability": 0.976318359375}, {"start": 3119.86, "end": 3120.28, "word": " DNA", "probability": 0.70654296875}, {"start": 3120.28, "end": 3121.54, "word": " وأشياء", "probability": 0.84248046875}, {"start": 3121.54, "end": 3122.88, "word": " مختلفة", "probability": 0.9892578125}, {"start": 3122.88, "end": 3126.0, "word": " فيه", "probability": 0.3470458984375}, {"start": 3126.0, "end": 3126.44, "word": " يعني", "probability": 0.779052734375}, {"start": 3126.44, "end": 3126.68, "word": " هذه", "probability": 0.732421875}, {"start": 3126.68, "end": 3127.32, "word": " الظواهر", "probability": 0.8298095703125}, {"start": 3127.32, "end": 3129.36, "word": " اليوم", "probability": 0.8701171875}, {"start": 3129.36, "end": 3130.02, "word": " بنوقف", "probability": 0.9446614583333334}, {"start": 3130.02, "end": 3130.36, "word": " لهذه", "probability": 0.7401123046875}, {"start": 3130.36, "end": 3131.04, "word": " اللحظة", "probability": 0.9976806640625}, {"start": 3131.04, "end": 3131.72, "word": " أنا", "probability": 0.84619140625}, {"start": 3131.72, "end": 3132.28, "word": " آسف", "probability": 0.9666341145833334}, {"start": 3132.28, "end": 3133.88, "word": " اليوم", "probability": 0.9365234375}, {"start": 3133.88, "end": 3134.62, "word": " خربطة", "probability": 0.9193115234375}, {"start": 3134.62, "end": 3134.8, "word": " من", "probability": 0.99072265625}, {"start": 3134.8, "end": 3135.2, "word": " عندي", "probability": 0.826416015625}, {"start": 3135.2, "end": 3136.32, "word": " بس", "probability": 0.9287109375}, {"start": 3136.32, "end": 3137.4, "word": " إن", "probability": 0.55615234375}, {"start": 3137.4, "end": 3137.54, "word": " شاء", "probability": 0.959716796875}, {"start": 3137.54, "end": 3137.78, "word": " الله", "probability": 0.96044921875}, {"start": 3137.78, "end": 3138.28, "word": " المرة", "probability": 0.93603515625}, {"start": 3138.28, "end": 3138.42, "word": " اللي", "probability": 0.6085205078125}, {"start": 3138.42, "end": 3138.66, "word": " جاي", "probability": 0.8466796875}, {"start": 3138.66, "end": 3139.28, "word": " بنراجع", "probability": 0.7308349609375}, {"start": 3139.28, "end": 3139.74, "word": " الأشياء", "probability": 0.9915771484375}, {"start": 3139.74, "end": 3140.0, "word": " وده", "probability": 0.8304036458333334}, {"start": 3140.0, "end": 3140.2, "word": " فيه", "probability": 0.70703125}, {"start": 3140.2, "end": 3140.62, "word": " أسئلة", "probability": 0.795654296875}, {"start": 3140.62, "end": 3141.66, "word": " وجروب", "probability": 0.70086669921875}, {"start": 3141.66, "end": 3142.04, "word": " الـ", "probability": 0.959228515625}, {"start": 3142.04, "end": 3142.34, "word": " WhatsApp", "probability": 0.54638671875}, {"start": 3142.34, "end": 3143.58, "word": " فاتحة", "probability": 0.9466552734375}, {"start": 3143.58, "end": 3145.48, "word": " يعني", "probability": 0.94091796875}], "temperature": 1.0}, {"id": 116, "seek": 316765, "start": 3147.39, "end": 3167.65, "text": "إذا حد عنده أسئلة ممكن نتناقش فيها يعطيكم العافية السلام عليكم السلام ورحمة الله يعطيك العافية مش عارف إذا دكتورة ده كنت سامعني لأ لكن عموما يعطيك العافية يعطيكم العافية يا دكاترا وإن شاء الله يعني إلى لقاءة قادمة بإذن الله السلام عليكم يعطيكم العافية", "tokens": [28814, 15730, 11331, 3215, 43242, 3224, 5551, 3794, 19986, 37977, 3714, 43020, 8717, 2655, 8315, 4587, 8592, 8978, 11296, 37495, 9566, 1829, 24793, 18863, 31845, 10632, 21136, 37440, 25894, 24793, 21136, 37440, 4032, 2288, 35571, 3660, 21984, 37495, 9566, 1829, 4117, 18863, 31845, 10632, 37893, 6225, 9640, 5172, 11933, 15730, 11778, 4117, 2655, 13063, 3660, 11778, 3224, 9122, 29399, 8608, 10943, 3615, 22653, 5296, 10721, 44381, 6225, 2304, 2407, 15042, 37495, 9566, 1829, 4117, 18863, 31845, 10632, 37495, 9566, 1829, 4117, 2304, 18863, 31845, 10632, 35186, 11778, 4117, 9307, 23557, 4032, 28814, 1863, 13412, 16606, 21984, 37495, 22653, 30731, 5296, 4587, 16606, 3660, 12174, 18513, 46007, 4724, 28814, 8848, 1863, 21984, 21136, 37440, 25894, 24793, 37495, 9566, 1829, 24793, 18863, 31845, 10632], "avg_logprob": -0.18343495498827803, "compression_ratio": 2.373056994818653, "no_speech_prob": 6.377696990966797e-06, "words": [{"start": 3147.39, "end": 3147.71, "word": "إذا", "probability": 0.79736328125}, {"start": 3147.71, "end": 3147.93, "word": " حد", "probability": 0.6533203125}, {"start": 3147.93, "end": 3148.27, "word": " عنده", "probability": 0.9833984375}, {"start": 3148.27, "end": 3148.79, "word": " أسئلة", "probability": 0.948486328125}, {"start": 3148.79, "end": 3149.29, "word": " ممكن", "probability": 0.95556640625}, {"start": 3149.29, "end": 3149.89, "word": " نتناقش", "probability": 0.9912109375}, {"start": 3149.89, "end": 3150.29, "word": " فيها", "probability": 0.781005859375}, {"start": 3150.29, "end": 3151.65, "word": " يعطيكم", "probability": 0.793701171875}, {"start": 3151.65, "end": 3152.21, "word": " العافية", "probability": 0.8494466145833334}, {"start": 3152.21, "end": 3152.99, "word": " السلام", "probability": 0.6993408203125}, {"start": 3152.99, "end": 3153.47, "word": " عليكم", "probability": 0.947998046875}, {"start": 3153.47, "end": 3156.13, "word": " السلام", "probability": 0.6748046875}, {"start": 3156.13, "end": 3156.49, "word": " ورحمة", "probability": 0.8392333984375}, {"start": 3156.49, "end": 3156.65, "word": " الله", "probability": 0.95458984375}, {"start": 3156.65, "end": 3156.93, "word": " يعطيك", "probability": 0.92431640625}, {"start": 3156.93, "end": 3157.15, "word": " العافية", "probability": 0.9430338541666666}, {"start": 3157.15, "end": 3157.27, "word": " مش", "probability": 0.525390625}, {"start": 3157.27, "end": 3157.49, "word": " عارف", "probability": 0.9933268229166666}, {"start": 3157.49, "end": 3157.59, "word": " إذا", "probability": 0.680419921875}, {"start": 3157.59, "end": 3157.97, "word": " دكتورة", "probability": 0.841015625}, {"start": 3157.97, "end": 3158.09, "word": " ده", "probability": 0.6593017578125}, {"start": 3158.09, "end": 3158.25, "word": " كنت", "probability": 0.963623046875}, {"start": 3158.25, "end": 3158.59, "word": " سامعني", "probability": 0.70281982421875}, {"start": 3158.59, "end": 3158.81, "word": " لأ", "probability": 0.4019775390625}, {"start": 3158.81, "end": 3159.09, "word": " لكن", "probability": 0.5556640625}, {"start": 3159.09, "end": 3159.43, "word": " عموما", "probability": 0.9639892578125}, {"start": 3159.43, "end": 3159.77, "word": " يعطيك", "probability": 0.984130859375}, {"start": 3159.77, "end": 3160.11, "word": " العافية", "probability": 0.9803059895833334}, {"start": 3160.11, "end": 3160.59, "word": " يعطيكم", "probability": 0.84150390625}, {"start": 3160.59, "end": 3160.87, "word": " العافية", "probability": 0.9845377604166666}, {"start": 3160.87, "end": 3161.21, "word": " يا", "probability": 0.98193359375}, {"start": 3161.21, "end": 3161.71, "word": " دكاترا", "probability": 0.803466796875}, {"start": 3161.71, "end": 3161.89, "word": " وإن", "probability": 0.8527018229166666}, {"start": 3161.89, "end": 3162.03, "word": " شاء", "probability": 0.9892578125}, {"start": 3162.03, "end": 3162.81, "word": " الله", "probability": 0.95703125}, {"start": 3162.81, "end": 3163.65, "word": " يعني", "probability": 0.800537109375}, {"start": 3163.65, "end": 3163.95, "word": " إلى", "probability": 0.9638671875}, {"start": 3163.95, "end": 3164.55, "word": " لقاءة", "probability": 0.8929443359375}, {"start": 3164.55, "end": 3165.05, "word": " قادمة", "probability": 0.990234375}, {"start": 3165.05, "end": 3165.27, "word": " بإذن", "probability": 0.817626953125}, {"start": 3165.27, "end": 3165.41, "word": " الله", "probability": 0.92626953125}, {"start": 3165.41, "end": 3165.73, "word": " السلام", "probability": 0.77587890625}, {"start": 3165.73, "end": 3166.29, "word": " عليكم", "probability": 0.91552734375}, {"start": 3166.29, "end": 3167.27, "word": " يعطيكم", "probability": 0.925048828125}, {"start": 3167.27, "end": 3167.65, "word": " العافية", "probability": 0.9744466145833334}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 3173.331875, "duration_after_vad": 3081.6456249999833}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/fBzW7egRH9k_raw.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/fBzW7egRH9k_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..f1ae487b7c294caca92903cbe546b4fc4f911165
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/fBzW7egRH9k_raw.srt
@@ -0,0 +1,2204 @@
+1
+00:00:00,880 --> 00:00:05,640
+الجزء الـ slide هذا بعد ما اتكلمنا كيف الـ DNA
+
+2
+00:00:05,640 --> 00:00:12,620
+شكله وكيف بتم عملية انقسام الخلايا أو نوعين
+
+3
+00:00:12,620 --> 00:00:17,560
+الانقسام بهدف ابقاء عدد الخلايا كما هما اللي هو
+
+4
+00:00:17,560 --> 00:00:24,020
+الـ Mitosis عشان يظل عدد الخلايا زي ما هماوالـ
+
+5
+00:00:24,020 --> 00:00:31,480
+Meiosis اللي هو موضوع لما يكون اللي هو الانخسام
+
+6
+00:00:31,480 --> 00:00:35,780
+المنصف حيث أنه يطلع عند الـ Gametes و بالـ Males و
+
+7
+00:00:35,780 --> 00:00:41,780
+الـ Females بتتبع فطوات قريبة من بعض على مرحلتين،
+
+8
+00:00:41,780 --> 00:00:47,140
+المرحل الأولى بتبدأ الخلية 2N بتصير 4N و بعدين
+
+9
+00:00:47,140 --> 00:00:53,770
+بتنقسم إلى الخلايا تبعتهااللي هو سواءً الـ Sperms
+
+10
+00:00:53,770 --> 00:00:59,970
+أو الـ Egg اللي بتطلع الآن الموضوع الثاني راح نبدأ
+
+11
+00:00:59,970 --> 00:01:06,910
+اليوم إحنا بعد ما بدأنا نحكي إنه الـ DNA هو المصدر
+
+12
+00:01:06,910 --> 00:01:11,450
+اللي بيحدد كيف راح يكون ترتيب البروتين أو الـ
+
+13
+00:01:11,450 --> 00:01:17,990
+Primary Structure تبع البروتين اللي هو ترتيب الـ
+
+14
+00:01:18,750 --> 00:01:21,290
+ترتيب الـ Amino Acids اللي هو الـ Primary
+
+15
+00:01:21,290 --> 00:01:24,650
+Structure للبروتين ويكون ترتيب الـ Amino Acids
+
+16
+00:01:24,650 --> 00:01:28,750
+طبعاً لازم تكونوا عارفين من ال Biochemistry أنه في
+
+17
+00:01:28,750 --> 00:01:32,950
+عنا عشرين أو واحد وعشرين Amino Acids حسب مرات تبقى
+
+18
+00:01:32,950 --> 00:01:38,230
+هيك ولي هيك فأحد هذه الطرق اللي هو حاطينها تحت
+
+19
+00:01:38,230 --> 00:01:42,110
+اللي هي هنا Abbreviations for Amino Acids فعنا
+
+20
+00:01:42,110 --> 00:01:50,100
+الألانين والأرجانين والأسبارجانين بالشكل هذاففي
+
+21
+00:01:50,100 --> 00:02:00,360
+ثلاث نظم لكتابة أسماء الـ Amino Acids في الـ
+
+22
+00:02:00,360 --> 00:02:07,500
+.. أنا والله خلّيني أشوف الكاميرا الـ .. إيه قاعد
+
+23
+00:02:07,500 --> 00:02:12,400
+المشاركة؟ المشكلة زي الـ «زوم» ما كنت أنا أدخل من
+
+24
+00:02:12,400 --> 00:02:18,530
+قبل مش راضي .. إيش اسمه؟stop recording share
+
+25
+00:02:18,530 --> 00:02:24,150
+screen start video
+
+26
+00:02:24,150 --> 00:02:29,450
+ناخذ التطبيق PowerPoint
+
+27
+00:02:51,820 --> 00:02:57,580
+وأقول له start my video هذا الجهاز مش جهازي ما هو
+
+28
+00:02:57,580 --> 00:03:05,960
+اسمه؟ مش جهازي؟ فمش عارف 100% طيب فبالنسبة لهناك
+
+29
+00:03:05,960 --> 00:03:10,480
+ثلاثة أنظمة للتعريف الـ «among us» بالعشرين اللي
+
+30
+00:03:10,480 --> 00:03:15,780
+هما يأمل ثلاث أحرف ذلك ألانين أو حرف الـA أو بالتو
+
+31
+00:03:15,780 --> 00:03:21,950
+كامل ألانين فهذه أسماءالـ Amino Acids وكتير من
+
+32
+00:03:21,950 --> 00:03:32,770
+الظواهر الحيوية والظواهر في حياة الإنسان نعتمد
+
+33
+00:03:32,770 --> 00:03:36,770
+على الـ Amino Acids يعني مثلا فينال، كيوتون،
+
+34
+00:03:36,770 --> 00:03:41,030
+نيوريا، مرض نتيجة الفينال الأنانين Metabolism
+
+35
+00:03:41,030 --> 00:03:47,430
+Problemأو مثلًا في عندنا Serine Protease أو عندنا
+
+36
+00:03:47,430 --> 00:03:51,830
+كذا فنستخدم كثير مصطلحات اللي دخل بالـ Amino Acids
+
+37
+00:03:51,830 --> 00:04:01,330
+فالآن حتى نفهم القطع اللي فوق اللي هي الـ Genetic
+
+38
+00:04:01,330 --> 00:04:11,380
+Code هذه طريقة ترميز الـ Amino Acids من خلالأحرف و
+
+39
+00:04:11,380 --> 00:04:16,020
+الـ Bases أو الـ Nitrogenous Bases تبعات الـ
+
+40
+00:04:16,020 --> 00:04:21,000
+Nucleotides فمن تركيب الـ DNA بنحوله لتركيب أو
+
+41
+00:04:21,000 --> 00:04:26,860
+ترتيب الـ Amino Acids فلو كان اللي اكتشفوه العلماء
+
+42
+00:04:26,860 --> 00:04:36,760
+أنه لو كان الأمر بيكون من خلال Single Nucleotide
+
+43
+00:04:38,390 --> 00:04:45,410
+كان نقدر نعمل شفرة لـ 4 amino acids لو كان عندي
+
+44
+00:04:45,410 --> 00:04:50,870
+Two Nucleotides بيثيروا هم اللي بيعملوا الـ
+
+45
+00:04:55,700 --> 00:05:01,540
+الـ Coding أو التشفير أنه Two Amino Acids فالأول
+
+46
+00:05:01,540 --> 00:05:05,380
+أربعة فينا واحد من أربع احتمالات والثاني أربع
+
+47
+00:05:05,380 --> 00:05:08,880
+احتمالات ثانية ففي الحالة دي راح يكون ستاشر
+
+48
+00:05:08,880 --> 00:05:15,560
+Nucleus ستاشر Amino Acids نقدر نرمز إليهم فثبت إنه
+
+49
+00:05:15,560 --> 00:05:20,560
+لأ هم ثلاثة كل ثلاثة بنقروا مع بعض وكل ثلاثة مع
+
+50
+00:05:20,560 --> 00:05:25,480
+بعض برمزوا ل Amino Acid واحدفعشان هيك بنسميهم
+
+51
+00:05:25,480 --> 00:05:30,240
+Codon أو Triplet أو كده عبارة عن ثلاث من الـ
+
+52
+00:05:30,240 --> 00:05:34,960
+Nucleotides حتى يرمزوا لواحد من الـ Amino Acid
+
+53
+00:05:34,960 --> 00:05:38,980
+طبعاً أربعة بأربعة بأربعة بتصير أربعة و ستين
+
+54
+00:05:38,980 --> 00:05:44,300
+فالأربعة و ستين زيادة عن الأشرين Amino Acid بس
+
+55
+00:05:44,300 --> 00:05:47,960
+بتغطيهم و راح نشوف كيف الأمور تتطور
+
+56
+00:05:52,380 --> 00:05:57,020
+الجدول هذا أمامكم حاطين بالأول ما هي الـ First
+
+57
+00:05:57,020 --> 00:06:03,400
+Base مرات بتكون U, C, A أو G طبعاً الـ U لأنها حلت
+
+58
+00:06:03,400 --> 00:06:10,780
+في الـ RNA مش الـ DNA الـ RNA حلت بدل الـ T الـ
+
+59
+00:06:10,780 --> 00:06:17,900
+Second Base هذا اللي هو ترتيبهم U, C, A, G وبعدين
+
+60
+00:06:17,900 --> 00:06:22,510
+هنا الـ Third Baseحاطينها بالترتيب شُلّي عندنا
+
+61
+00:06:22,510 --> 00:06:29,290
+فبنلاحظ إذا كان عندنا ترتيب مثلا كودون ثلاثي U U U
+
+62
+00:06:29,290 --> 00:06:36,710
+هذا فلع الألاني U U C فلع الألاني كمان U U A لـ C
+
+63
+00:06:36,710 --> 00:06:46,690
+U U G لـ C C U U لـ C C U C لـ Cالـ PUA Lucy يعني
+
+64
+00:06:46,690 --> 00:06:52,150
+إنها أربعين، إنها أربعة وستين، بده رمز للعشرين
+
+65
+00:06:52,150 --> 00:06:56,610
+فيكم، فبصير عنده تكرارات، بعض الـ Amino Acids يمكن
+
+66
+00:06:56,610 --> 00:07:01,090
+مالهاش غير مثلًا زي المستانيينين الـ AUG هذا
+
+67
+00:07:01,090 --> 00:07:04,810
+الترتيب تبعها، فالـ
+
+68
+00:07:09,290 --> 00:07:17,410
+الآن الترتيبات هذه زي ما أنتم شايفين عشان يكون الـ
+
+69
+00:07:17,410 --> 00:07:24,310
+… نرمز لـ 20 Amino Acids من خلال ثلاثيات من الـ
+
+70
+00:07:24,310 --> 00:07:29,470
+Nucleotides ثلاثيات من الـ Nitrogen Bases بحيث أنه
+
+71
+00:07:29,470 --> 00:07:35,810
+يعطينا إياها بس بدنا نلاحظ كمان شغل تاني إذا
+
+72
+00:07:35,810 --> 00:07:45,430
+بتنتبهوا للجدولUAA وUAG وUGA هدولة stop كودهم
+
+73
+00:07:45,430 --> 00:07:51,870
+انتبهوا هدولة الثلاثة حاطينهم انه يعني عشان
+
+74
+00:07:51,870 --> 00:07:58,390
+القراءة تبدأ من محل معين وتنتهي في محل معين بالأول
+
+75
+00:07:58,390 --> 00:08:03,160
+لازم يكون عندي أنا بدور على ال well startهي لازم
+
+76
+00:08:03,160 --> 00:08:08,480
+يكون start كده مش
+
+77
+00:08:08,480 --> 00:08:16,620
+شايف أين برولين وكده وفيه ال stop ال stop عشان
+
+78
+00:08:16,620 --> 00:08:25,780
+يوقف قراءة ال RNA في محل معين هنا ال start مانيش
+
+79
+00:08:25,780 --> 00:08:30,220
+شايفه بس
+
+80
+00:08:30,220 --> 00:08:35,730
+لازم يكون في محلبيخلّي النظام
+
+81
+00:08:35,730 --> 00:08:42,850
+في قراية الـ Messenger RNA ويعني في عملية الـ
+
+82
+00:08:42,850 --> 00:08:47,570
+Transcription للـ DNA لـ Messenger RNA بدي يقولّه
+
+83
+00:08:47,570 --> 00:08:51,930
+ابدأ من هذه المكانة فالمحل البداية لازم يكون ترتيب
+
+84
+00:08:51,930 --> 00:08:56,110
+معين بيقولّه ابدأ من هنا وفي نفس الوقت في إشي
+
+85
+00:08:56,110 --> 00:09:01,620
+بيقولّه انتهي هنا فهذه النقطة اللي بدنا إياهاوهيك
+
+86
+00:09:01,620 --> 00:09:07,340
+النظام اللي بتتم من خلاله ترميز الـ Amino Acids
+
+87
+00:09:07,340 --> 00:09:11,820
+اللي بتدخل في ترتيب البروتيد الناتج عن هذا الجين
+
+88
+00:09:11,820 --> 00:09:17,340
+فالجين هو اللي في الـ DNA هو اللي راح يعطينا الـ
+
+89
+00:09:17,340 --> 00:09:22,420
+Messenger RNA هو اللي راح يعطينا إياه فأظن هنا الـ
+
+90
+00:09:22,420 --> 00:09:28,040
+ATG وطبعاً يعني الفكرة أنه إحنا بنقرا الـ
+
+91
+00:09:28,040 --> 00:09:29,120
+Transcription
+
+92
+00:09:31,290 --> 00:09:35,970
+كل ثلاثة مع بعض، كل ثلاثة مع بعض، كل ثلاثة مع بعض
+
+93
+00:09:35,970 --> 00:09:40,650
+فالـ Transcription أعطانا الـ Messenger RNA والـ
+
+94
+00:09:40,650 --> 00:09:46,490
+Translation راح تعطينا الـ Amino Acids حطين هنا
+
+95
+00:09:46,490 --> 00:09:54,590
+الأسماء اللي هي المفروض بالأحرف لـ Amino
+
+96
+00:09:54,590 --> 00:10:00,350
+Acids اللي تدخل في تركيب البروتين هذافهذه اسمها
+
+97
+00:10:00,350 --> 00:10:07,490
+كلمات مهمة كثير اللي هي أنه في عندي startup Start
+
+98
+00:10:07,490 --> 00:10:13,250
+on Codon و بعدين ببدأ عملية Transcription وعطينا
+
+99
+00:10:13,250 --> 00:10:19,110
+الـ Messenger RNA الـ Messenger RNA كل ثلاثة بدخل
+
+100
+00:10:19,110 --> 00:10:25,610
+فيه اللي هو Transferial RNAبتبركب على الـ ribosome
+
+101
+00:10:25,610 --> 00:10:31,590
+اللي فيه ribosome RNA على الـ messenger RNA بحيث
+
+102
+00:10:31,590 --> 00:10:38,430
+يقرأ الـ الـ الـ الـ البروتينات الموجودة بحيث
+
+103
+00:10:38,430 --> 00:10:45,110
+يعطينا بالأقيل البروتين ماشي فالـ translational
+
+104
+00:10:45,110 --> 00:10:49,210
+reading frame is determined by the AUG initiator
+
+105
+00:10:49,210 --> 00:10:53,840
+codon اللي حفظ عليه السحنوالـ Subsequent Codewords
+
+106
+00:10:53,840 --> 00:10:56,200
+Specifying the Binary Assets ‏are indicated in
+
+107
+00:10:56,200 --> 00:11:00,440
+blue، ناشي ‏The two other potential frames are not
+
+108
+00:11:00,440 --> 00:11:09,560
+tuned، ناشي فالـ هنا الـ AUG هو البداية يعني هذا
+
+109
+00:11:09,560 --> 00:11:16,920
+أجى Messenger RNA عشان يكون خربط أو لا إشيلحد
+
+110
+00:11:16,920 --> 00:11:23,140
+بيصير الـ Ribosome يبدأ يلف ويشبك عليه وينتبه لحد
+
+111
+00:11:23,140 --> 00:11:28,220
+ما يشكوك هدولة في ثلاثة بعدين بيصير يقرا فيهم فهيك
+
+112
+00:11:28,220 --> 00:11:34,700
+الظاهرة اللي بتتم في عملية
+
+113
+00:11:34,700 --> 00:11:40,520
+بناء البروتين من الـ Messenger RNA من الـ DNA
+
+114
+00:11:40,520 --> 00:11:44,880
+وبتكون هي هيك موجودة إن شاء الله الأمور واضحة
+
+115
+00:11:49,250 --> 00:11:54,110
+على الـ WhatsApp احكولي إذا أنا آسف جدا اليوم غريب
+
+116
+00:11:54,110 --> 00:11:57,870
+يعني إن شاء الله المرة الجاية بتكون أحسن وانا ماني
+
+117
+00:11:57,870 --> 00:12:02,490
+عارف شو اللي صار يعني بدا يمكن أعد فرمات الـ hard
+
+118
+00:12:02,490 --> 00:12:07,670
+disk إذا في أسئلة ابعتلي إياها على الـ WhatsApp
+
+119
+00:12:07,670 --> 00:12:14,510
+أنا أفتح الأثنين أثناء اللي نيجي نتطلع على بعض الـ
+
+120
+00:12:29,340 --> 00:12:35,840
+الآن هناك ترتيب مطلوبة حتى يلف السلك تبع الـ DNA
+
+121
+00:12:35,840 --> 00:12:41,720
+على حاله ففيه إيش اسمه الـ nucleosomes وإيش اسمه
+
+122
+00:12:41,720 --> 00:12:47,020
+الـ histones والسنتين مطلوبات حتى الـ DNA يلف على
+
+123
+00:12:47,020 --> 00:12:53,360
+حاله بغض انه يصير عملية برضه بالشكل المطلوب لعملية
+
+124
+00:12:53,360 --> 00:13:01,300
+الـ meiosis و الـ mitosisالـ .. الآن اتكلمت هيك
+
+125
+00:13:01,300 --> 00:13:07,520
+بشكل .. حتى يعني نفهم جانب آخر وشو ضرورة الواحد
+
+126
+00:13:07,520 --> 00:13:14,520
+يكون فاهم هيك بشكل مبدأ Concept هيك ال .. ال .. ال
+
+127
+00:13:14,520 --> 00:13:18,300
+.. ليش الـ Nucleosomes و الـ Histones غير قضية
+
+128
+00:13:18,300 --> 00:13:23,820
+احتجاج نقلهم في عملية .. في عملية انقسام الخلية
+
+129
+00:13:24,820 --> 00:13:31,580
+اللي هي ظاهرة التحكم إنه أحيانًا كثيرة بتتم التحكم
+
+130
+00:13:31,580 --> 00:13:42,960
+بالـ DNA عن طريق آليات، Mechanisms تستطلب أنه أدد
+
+131
+00:13:42,960 --> 00:13:49,420
+كبير من الجينات يتم تشغيلها في مكان معين أو
+
+132
+00:13:49,420 --> 00:13:54,250
+توقيفها في مجال آخروهذه إليها دخل أحيانًا أو إليها
+
+133
+00:13:54,250 --> 00:13:59,370
+دخل مهم في اللي بنسميهم الـ Polygenic Diseases
+
+134
+00:13:59,370 --> 00:14:06,330
+يعني الأمراض اللي فيها عدد كبير مشترك من الجينات
+
+135
+00:14:06,330 --> 00:14:12,250
+بتسبب المرض هذه بتكون أنه عدد كبير مش جين واحد
+
+136
+00:14:12,250 --> 00:14:16,010
+يعني إحنا راح ناخد بعد شوية بإنه بنقسم الأمراض
+
+137
+00:14:16,010 --> 00:14:21,340
+لثلاث أنواع ورافياًفيه كرموزومال يعني كرموزوم كامل
+
+138
+00:14:21,340 --> 00:14:27,600
+بار، ذاد، نقص، كده وفيه Mendelian يعني One-G اللي
+
+139
+00:14:27,600 --> 00:14:31,160
+هو اللي عامل المشكلة فدول أمراض بشكل عام نادرة
+
+140
+00:14:31,160 --> 00:14:36,260
+الأمراض غالبية العظمة زي السكري، الضغط، الربوء،
+
+141
+00:14:36,260 --> 00:14:40,620
+كده هذه أشياء بتلاقي أن مجموعة كبيرة من الجينات
+
+142
+00:14:40,620 --> 00:14:44,540
+بتتم تأثير
+
+143
+00:14:44,540 --> 00:14:50,610
+عليهاطريقة كيف إنه عدد كبير من الجينات سواء تشتغل
+
+144
+00:14:50,610 --> 00:14:54,890
+كثير أو تشتغل قليل أو كيف تختلط بطريقة معينة أو
+
+145
+00:14:54,890 --> 00:14:59,270
+أخرى باعتمد على ما يسمى الـ Epigenetic Mechanisms
+
+146
+00:14:59,270 --> 00:15:04,510
+فالـ Epigenetic Mechanisms على قل المشهورات منهم
+
+147
+00:15:04,510 --> 00:15:09,370
+غير اللي بيسموه Micro RNA بتصير عملية الـ DNA
+
+148
+00:15:09,370 --> 00:15:14,820
+Methylationيعني الـ Retinal Group بتيجي وتشبك على
+
+149
+00:15:14,820 --> 00:15:23,700
+قطعة معينة أو على نيوكلوتايد معين في الـ DNA لما
+
+150
+00:15:23,700 --> 00:15:30,920
+تصير عندي الـ DNA methylation بتغير وظيفة الجين
+
+151
+00:15:30,920 --> 00:15:35,900
+هذا وطريقة تانية اللي هي الـ Modification لـ
+
+152
+00:15:35,900 --> 00:15:39,780
+Histone Tail الـ Histone و الـ Nucleosomes و الـ
+
+153
+00:15:39,780 --> 00:15:44,650
+Histonesبصيرهم برضه عمليات «metallation» وهدولة
+
+154
+00:15:44,650 --> 00:15:48,290
+يعني بيغيروا
+
+155
+00:15:48,290 --> 00:15:54,510
+في شكل وظيفة الـ «DNA» بس ما بيغيروا في ترتيب الـ
+
+156
+00:15:54,510 --> 00:15:57,310
+«Nucleotides» و لا بيغيروا يعني ما بنقدر نعتبرهم
+
+157
+00:15:57,310 --> 00:16:02,830
+تفرات ما بنقدر نعتبرهم زي بقية الأمراض لما ناخد
+
+158
+00:16:02,830 --> 00:16:07,590
+عليها الـ «coding» فـ Epigenetic يعني بيسموه علم
+
+159
+00:16:07,590 --> 00:16:14,740
+التخلقبكون إنه فيه اختلالات في وظيفة الـ DNA على
+
+160
+00:16:14,740 --> 00:16:20,980
+مستوى حدد كبير من الجينات مع بعض بكون نتيجة ظواهر
+
+161
+00:16:20,980 --> 00:16:25,180
+زي عملية الـ methylation للـ DNA أو تغيير على الـ
+
+162
+00:16:25,180 --> 00:16:30,160
+histones أو الـ nucleosomes اللي مطلوبة حتى لف الـ
+
+163
+00:16:30,160 --> 00:16:34,320
+DNA بالشكل اللي بنشوفه فوق حتى يعطينا كرومزوم شكل
+
+164
+00:16:34,320 --> 00:16:38,840
+مضغوط يعرف يفصل عن بعضهفيه آليات أخرى للـ
+
+165
+00:16:38,840 --> 00:16:45,140
+Epigenetics نحكي عنها بعدين بس يعني هاي بواهر
+
+166
+00:16:45,140 --> 00:16:53,540
+موجودة وأشياء مهمة هنا الفرق الكيماوي لـ Cytosine
+
+167
+00:16:53,540 --> 00:16:58,980
+مع الـ 5-Methylcytosine وممكن 5
+
+168
+00:16:58,980 --> 00:17:04,030
+-Hydroxynethylcytosine كيف أنه بتصير تغييراتالـ
+
+169
+00:17:04,030 --> 00:17:09,230
+DNA على مستوى الـ DNA لطبيعة الـ methylation وهاي
+
+170
+00:17:09,230 --> 00:17:18,550
+حسب درجتها وكمياتها بتأثر على وظيفة الـ DNA اليوم
+
+171
+00:17:18,550 --> 00:17:27,630
+والآن نتيجة ضرفنا يعني يمكن راح يكون صعب أن أسمع
+
+172
+00:17:27,630 --> 00:17:31,430
+منكم بس إذا فيها أي أسئلة ان شاء الله بالـ group
+
+173
+00:17:31,430 --> 00:17:33,670
+أو بكذا بنسويها مرة تانية
+
+174
+00:17:36,640 --> 00:17:43,380
+الآن أحيانًا الترتيب
+
+175
+00:17:43,380 --> 00:17:50,090
+وكيف الـ DNA راح يصيرأحنا بالـ Nucleus الأصل إنه
+
+176
+00:17:50,090 --> 00:17:56,890
+الكرموزومات كلها بالأول يعني زي ما تقولوا خاردة
+
+177
+00:17:56,890 --> 00:18:03,270
+حالها و تستخدم عشان تقرأ الجينات و كده و إنه
+
+178
+00:18:03,270 --> 00:18:08,270
+دايماً لما يصير عندي قراءة لجين معين لازم بالأول
+
+179
+00:18:08,270 --> 00:18:16,540
+يصير عملية تنشيط لهذا الجينيفك حتى يبدأ يقرأ أمن
+
+180
+00:18:16,540 --> 00:18:22,260
+الـ DNA تبعه ويعطينا الـ Messenger RNA في عندي
+
+181
+00:18:22,260 --> 00:18:29,200
+بيسموها الـ Promoter Regions يعني إشي بده يفهم
+
+182
+00:18:29,200 --> 00:18:36,020
+آليات النسخ أنه ابدأ من هنا وهي اللي هي بتتم عملية
+
+183
+00:18:36,020 --> 00:18:40,400
+استفادة منها في التحكم في وظيفة الـ DNA عشان يبدأ
+
+184
+00:18:40,400 --> 00:18:46,590
+يشتغلوهدولة يعني آليات التحكم ممكن إشي مباشر قبل
+
+185
+00:18:46,590 --> 00:18:51,210
+الـ DNA زي هيك الـ Promoter Region بنسميها أو
+
+186
+00:18:51,210 --> 00:18:57,010
+أحيانًا بتكون قطعة أخرى من مسافة بعيدة يعني زي هيك
+
+187
+00:18:57,010 --> 00:19:03,010
+ممثلينا إنه إشي قبله مسافة طويلة بس برضه بتدخل إنه
+
+188
+00:19:03,010 --> 00:19:09,270
+يتحكم Long Range Regulatory Element فبتلاقي من محل
+
+189
+00:19:09,270 --> 00:19:17,900
+بعيدحتى يتحكم بالـ Intel وهذا يعني يبدو
+
+190
+00:19:17,900 --> 00:19:24,460
+الواحد يستوعبها على إنه هي الظواهر
+
+191
+00:19:24,460 --> 00:19:29,340
+اللي احنا الآن بلاحظها
+
+192
+00:19:29,340 --> 00:19:38,960
+وبتحاول تفسر كيفية وظيفة هذا النظام المعطليعني
+
+193
+00:19:38,960 --> 00:19:45,280
+احنا صحيح في عندنا 25 ألف جين بس مش بس ان الواحد
+
+194
+00:19:45,280 --> 00:19:49,700
+جين وانتهينا يعني نفس الجين ممكن أكتر من قطعة لازم
+
+195
+00:19:49,700 --> 00:19:54,920
+الجين إله بداية وإله نهاية 25 ألف جين لكل أنواع
+
+196
+00:19:54,920 --> 00:20:00,100
+خلايا الجسم في الخلية مثلا الفلانية مثلا خلية عضلة
+
+197
+00:20:00,100 --> 00:20:05,320
+بدها Acetinomycin عشان هي عضلةبينما مثلًا خليط
+
+198
+00:20:05,320 --> 00:20:09,560
+الدم الحمراء بدها Hemoglobin خليط المناعة بدها
+
+199
+00:20:09,560 --> 00:20:14,060
+Immunoglobulin البروتين تبعها فكيف كل واحدة تهتزي
+
+200
+00:20:14,060 --> 00:20:20,600
+إنه تنشط ولا تتطبط ولا تغير ولا كذا من خلال أنظمة
+
+201
+00:20:20,600 --> 00:20:26,600
+التحكم فجزء من أنظمة التحكم في شكل الـ DNA نفسه
+
+202
+00:20:26,600 --> 00:20:30,980
+طريقة تركيبه و تركيبه حتى يستطيع إنه ينقص من قسم
+
+203
+00:20:30,980 --> 00:20:41,710
+الخلاياوفي نفس الوقت حتى تكون وظيفة يعني حتى تقوم
+
+204
+00:20:41,710 --> 00:20:49,090
+الخلية بوظيفتها الـ Methylation هي سؤال احنا يعني
+
+205
+00:20:49,090 --> 00:20:52,810
+حالياً أنا لست على الطلاع إنه إله فايدة أو وظيفة
+
+206
+00:20:52,810 --> 00:20:58,690
+معينة، ظاهرة و بتحدث يعني الأحيان
+
+207
+00:20:59,330 --> 00:21:03,430
+إذا قعدت نستفيد منها البروتينات مثلا بتمن عملية
+
+208
+00:21:03,430 --> 00:21:07,430
+الـ glycosylation للبروتين كل البروتين وقعدت
+
+209
+00:21:07,430 --> 00:21:11,090
+نستفيد منها في التحكم في السكري لإنه بنشوف قداش
+
+210
+00:21:11,090 --> 00:21:15,150
+نسبة الـ glycosylated hemoglobin percentage فهي
+
+211
+00:21:15,150 --> 00:21:23,490
+أعتبرها ظاهرة بتحدث ودرجتها ووجودها
+
+212
+00:21:23,490 --> 00:21:27,450
+يعني هي ظاهرة بتحدث، هاي أولاً، بسشو هدفها؟ أنا
+
+213
+00:21:27,450 --> 00:21:31,690
+ماعندي اطلاع إنه إلها وظيفة معينة بس لما تحدث
+
+214
+00:21:31,690 --> 00:21:37,810
+بتأثر في وظيفة الـ Gene بحيث أنه بنتج عنه اختلافات
+
+215
+00:21:37,810 --> 00:21:44,390
+والجيار المختلفة ممكن
+
+216
+00:21:44,390 --> 00:21:49,480
+يعني بقول إنه بيأثر على وظيفة الـ Gene سواءأحيانًا
+
+217
+00:21:49,480 --> 00:21:52,860
+بعضها ممكن يتنشط وبعضها ممكن يتطبط، أنا مش
+
+218
+00:21:52,860 --> 00:21:56,280
+بالضرورة يعني في كثير من الأمراض مثلًا، الأمراض
+
+219
+00:21:56,280 --> 00:21:59,680
+اللي ربه أنا على خيلها عليها، في مجموعة جينات
+
+220
+00:21:59,680 --> 00:22:05,160
+كثيرة بتصير لها عملية تنشيط، وفي جينات أخرى بتصير
+
+221
+00:22:05,160 --> 00:22:11,360
+عملية تخبير، وهذه يعني زي ما بقول يعني رابط المثال
+
+222
+00:22:11,360 --> 00:22:16,130
+قبل ذلك، زي فرقة موسيقية يعنيالـ Orchestra
+
+223
+00:22:16,130 --> 00:22:21,410
+بتشوفوهم مثلا قاعدين حوالي ميت عازف فالمية مثلا في
+
+224
+00:22:21,410 --> 00:22:26,370
+لحظة معينة بدك كلهم أو ربعهم أو جزء معين أو نوعي
+
+225
+00:22:26,370 --> 00:22:31,490
+معين يتنشطوا الجزء بدك ياهم يتطبطوا فهذه كلها
+
+226
+00:22:31,490 --> 00:22:36,870
+واردة يعني فهي ظاهرة بتحدث وهي ظاهرة تشارك في
+
+227
+00:22:36,870 --> 00:22:44,890
+التحكم في وظيفة الـ DNA وبالتالي قد تكون لها يعني
+
+228
+00:22:45,370 --> 00:22:50,570
+دور في حكينا الأمراض اللي بنعتبرها polygenic يعني
+
+229
+00:22:50,570 --> 00:22:55,190
+الأمراض اللي فيها ليس جين واحد، مش مندالين، راح
+
+230
+00:22:55,190 --> 00:22:59,290
+تكون الأمراض اللي هي زي الضغط والسكري والربو أشياء
+
+231
+00:22:59,290 --> 00:23:05,290
+ويراتية، أشياء تكثر في عائلات معينة بس وجزة منها
+
+232
+00:23:05,290 --> 00:23:10,070
+ويراتي صحيح ولكن مش مندالين، مش جين واحد هو المسبب
+
+233
+00:23:10,070 --> 00:23:10,510
+للمرض
+
+234
+00:23:15,670 --> 00:23:21,130
+فأحيانًا اللي بدنا
+
+235
+00:23:21,130 --> 00:23:25,630
+ننتبهه من الظواهر الأخرى اللي بتعمل واحنا بنحاول
+
+236
+00:23:25,630 --> 00:23:32,310
+نصف شو بيصير في جسم الإنسان أنه مثلًا
+
+237
+00:23:32,310 --> 00:23:38,390
+أنا لأني متأكد 100% من هذا الكلام وفي جانب درسته
+
+238
+00:23:38,390 --> 00:23:43,510
+بشكل كبيربالنسبة للـ Protein تبع الـ
+
+239
+00:23:43,510 --> 00:23:46,750
+Immunoglobulin تبع اللي موجود بيشتغل في الـ B
+
+240
+00:23:46,750 --> 00:23:52,990
+-Lymphocyte ماشي ال Immunoglobulin أنا عندي Two
+
+241
+00:23:52,990 --> 00:23:57,850
+copies of the DNA واحد من أبوي واحد من أمي أثنانهم
+
+242
+00:23:57,850 --> 00:24:03,650
+عليهم جزء من الـ DNA للـ Heavy Chain للـ Heavy
+
+243
+00:24:03,650 --> 00:24:08,090
+Chain وفيه لل Light Chain أربع copies يعني فنتين
+
+244
+00:24:08,090 --> 00:24:13,940
+فنتينوالـ Heavy Chain واحد بواحد ففيه Syntax بس في
+
+245
+00:24:13,940 --> 00:24:20,140
+أي خلية من الـ B-Lymphocyte لوحدها بتكون فقط نسخة
+
+246
+00:24:20,140 --> 00:24:24,120
+واحدة من الـ Heavy Chain ونسخة واحدة من الـ Light
+
+247
+00:24:24,120 --> 00:24:27,780
+Chain هم اللي شقالين بالنسبة للـ Heavy Chain كان
+
+248
+00:24:27,780 --> 00:24:32,060
+عندي خيارين طلعلي خيار واحد أو بس واحد هو الفعال
+
+249
+00:24:32,060 --> 00:24:36,380
+الثاني بيبقى له ساكن لأن لا يتم عملية الـ
+
+250
+00:24:36,380 --> 00:24:40,500
+Transcription و Translation لهوبالنسبة للـ Light
+
+251
+00:24:40,500 --> 00:24:44,600
+Chain مع أن عندي أربع احتمالات بس في أي خلية بيكون
+
+252
+00:24:44,600 --> 00:24:52,920
+واحد فقط هو اللي شغال فاللي بدنا نذكره هنا أنه هذه
+
+253
+00:24:52,920 --> 00:24:57,760
+بدنا نسميه «mono-allelic expression» يعني في هذه
+
+254
+00:24:57,760 --> 00:25:04,300
+الخلية الـ DNA الـ RNA أو الناتج اللي هو نتيجة الـ
+
+255
+00:25:04,300 --> 00:25:11,780
+DNA بيكون من كوفي واحدةفمثلًا هنا في عندى بنسميه
+
+256
+00:25:11,780 --> 00:25:15,540
+«mono-allelic expression» وهنا «balanced
+
+257
+00:25:15,540 --> 00:25:18,860
+expression» يعني الأثنين بيشتركوا أنه يصير عملية
+
+258
+00:25:18,860 --> 00:25:22,620
+الـ Transcription وبعدين Translation في اللوم وفي
+
+259
+00:25:22,620 --> 00:25:25,980
+أحيانًا بيكون عندى ظواهر اللي يسمونه «allelic
+
+260
+00:25:25,980 --> 00:25:29,720
+imbalance» يعني هنا الغالبين العظمى جاي من هنا بس
+
+261
+00:25:29,720 --> 00:25:36,320
+هداك موجود بس كمية قليلة فالـ Snapsاللي موجودة في
+
+262
+00:25:36,320 --> 00:25:39,380
+الـ RNA مش عارف ليش حطوا هاي الـ SNP بالذات اللي
+
+263
+00:25:39,380 --> 00:25:44,280
+هي Single Nucleotide Polymorphism يعني الـ SNP
+
+264
+00:25:44,280 --> 00:25:49,120
+هدولة هما القاليه اللي استخدمناهم عشان نعرف أن هاي
+
+265
+00:25:49,120 --> 00:25:54,560
+أجت من هذا وهنا أجن بالنص من هنا وهنا يعني الـ SNP
+
+266
+00:25:54,560 --> 00:25:58,800
+هو Single Nucleotide Polymorphism راح نحكي عنه بعد
+
+267
+00:25:58,800 --> 00:26:06,420
+شوية فمن خلاله بقدر أعرف أني نسخةالـ DNA اللي تم
+
+268
+00:26:06,420 --> 00:26:13,540
+الـ Transcription تبعها بحيث أنه أعطاني الـ
+
+269
+00:26:13,540 --> 00:26:17,460
+RNA هذا فالفكرة
+
+270
+00:26:17,460 --> 00:26:22,220
+هنا أنه صحيح أنا عند جينين أو نسختين من الـ
+
+271
+00:26:22,220 --> 00:26:28,060
+Chromosomes ونسختين من الجينات وكذا بس مش دايماً
+
+272
+00:26:28,060 --> 00:26:32,140
+أنه أثنين لازم أثنين يشتغلوا أحياناًالإثنين
+
+273
+00:26:32,140 --> 00:26:36,860
+بيشتغلوا زي بعض تمامًا وبكون موجودين يعني مثلًا
+
+274
+00:26:36,860 --> 00:26:40,340
+الـ Hemoglobin في Alpha و Beta Chain راح ناخدها
+
+275
+00:26:40,340 --> 00:26:44,980
+الـ Beta Chain فيها نسخة واحدة واسنتين شغلتها الـ
+
+276
+00:26:44,980 --> 00:26:50,500
+Alpha Chain فيه أربعة لأنه فيه على كل كروموزوم Two
+
+277
+00:26:50,500 --> 00:26:57,220
+Alpha Chain Gen فبصير عندي أربعة مصادر ممكن أنا
+
+278
+00:26:57,220 --> 00:27:02,200
+أخد أي واحدة منهاممكن الأربع كلهم يشتغلوا ممكن بس
+
+279
+00:27:02,200 --> 00:27:05,500
+واحد اللي يشتغل ممكن أثنان يشتغلوا ممكن ثلاثة
+
+280
+00:27:05,500 --> 00:27:06,560
+يشتغلوا ممكن الأربع
+
+281
+00:27:22,930 --> 00:27:30,130
+جاية من الـ Beta
+
+282
+00:27:30,130 --> 00:27:36,010
+-Gene الأصل والـ Beta-Gene موجودة في نسكتين عندي
+
+283
+00:27:36,010 --> 00:27:43,530
+واحدة من أبوي واحدة من أمي فلما
+
+284
+00:27:43,530 --> 00:27:50,530
+نكون ندرس هذا الموضوع بشكل تفصيلي من خلالدراسة
+
+285
+00:27:50,530 --> 00:27:54,550
+الفروق الدقيقة هتكون على مستوى Single Nucleotide
+
+286
+00:27:54,550 --> 00:27:58,730
+Substitution لليه SNP؟ لليه Single Nucleotide
+
+287
+00:27:58,730 --> 00:28:02,650
+Polymerism؟ لما أستخدم هذه التقنية أني أنا أدرس
+
+288
+00:28:02,650 --> 00:28:08,350
+الجين هذا من وين أجا البروتين هل هو من الكروموزوم
+
+289
+00:28:08,350 --> 00:28:11,290
+اللي أجاني من أبوي ولا الكروموزوم اللي أجاني من
+
+290
+00:28:11,290 --> 00:28:16,730
+أمي بقدر أنا أدرس هذا الموضوع فلما أجي أدرس هذا
+
+291
+00:28:16,730 --> 00:28:24,660
+الموضوع ماشيبلاقي إن أنا عندي أكثر من احتمال في
+
+292
+00:28:24,660 --> 00:28:29,500
+حالات بتلاقي هذا الـ chromosome مثلا نفترض هذا الـ
+
+293
+00:28:29,500 --> 00:28:32,860
+chromosome اللي وردته من أبوي وكان في الجانب
+
+294
+00:28:32,860 --> 00:28:38,220
+الإفلاني يعني مثلا ناخد نفترض مثلا افتراض اللي هو
+
+295
+00:28:38,220 --> 00:28:43,520
+مثلا الـ ABO blood group راح تلاقي إن هنا الموقع
+
+296
+00:28:43,520 --> 00:28:49,220
+تبع الـ ABO blood groupوهذا الـ «جينات» الـ «جين»
+
+297
+00:28:49,220 --> 00:28:55,240
+المسؤول عن هذه الخاصية أو هذه الـ Blood Group
+
+298
+00:28:55,240 --> 00:29:00,200
+فاللي راح ألاقيه بالأخير هو أن أنا شايف الـ
+
+299
+00:29:00,200 --> 00:29:04,400
+Protein الـ Protein من أين بدي ييجي؟ بدي ييجي من
+
+300
+00:29:04,400 --> 00:29:07,880
+الـ RNA وبعدين بيعطيني الـ Protein
+
+301
+00:29:10,370 --> 00:29:15,430
+لو أنا هنا في الفتحة هذه بالضبط أنا بدرس على مستوى
+
+302
+00:29:15,430 --> 00:29:19,430
+شو صار للـ RNA يعني لسه ماكملت أني أشوف شو هو الـ
+
+303
+00:29:19,430 --> 00:29:24,850
+Protein وقفت التفاعل ووقفت الوضع المرحلة المعينة
+
+304
+00:29:24,850 --> 00:29:33,070
+ففي حالة الـ ABO System ماشي إذا واحد مثلا أخد
+
+305
+00:29:33,070 --> 00:29:41,980
+كروموزوم وعليه موقع TA من أبوهوأخد B من أمه شو
+
+306
+00:29:41,980 --> 00:29:46,060
+اللي راح يصير في جسمه راح تلاقي في الغالب Balance
+
+307
+00:29:46,060 --> 00:29:52,940
+Expression هتلاقي الـA والـB موجودة ويعني اثنان هم
+
+308
+00:29:52,940 --> 00:29:58,940
+شغلات واثنان موجودين بنفس الطريقة بنفس الكمية في
+
+309
+00:29:58,940 --> 00:30:07,480
+أوقات أو في جينات أخرى بكونفحيح عندى جينين طبعاً
+
+310
+00:30:07,480 --> 00:30:12,680
+خاصة لوسختين من نفس الجين واحياناً يعني مثلا الـ
+
+311
+00:30:12,680 --> 00:30:16,160
+Alpha Chain تبعت الـ Hemoglobin فيها Two copies
+
+312
+00:30:16,160 --> 00:30:20,640
+يعني Total يصير عندى أربع Two copies على One
+
+313
+00:30:20,640 --> 00:30:24,300
+chromosome وTwo copies على ال chromosome التاني
+
+314
+00:30:24,300 --> 00:30:29,960
+فعندي أربعولكن برغم وجود الأربعة مش الأربعة كلهم
+
+315
+00:30:29,960 --> 00:30:34,180
+شغالات لأ بيكون عندى واحد بس شغال فيه ظاهرة هي
+
+316
+00:30:34,180 --> 00:30:39,800
+بتحدث وانا هي في المناعة ندرسها ونعرفها ونفهمها
+
+317
+00:30:39,800 --> 00:30:44,560
+حتى بيسموها ان الواحد هذا لما ينجح ويشتغل ويكون هو
+
+318
+00:30:44,560 --> 00:30:48,640
+الناجح بيسكر على التانية بيسموها Allelic Exclusion
+
+319
+00:30:49,130 --> 00:30:56,490
+يعني إنه بمنع النسخ
+
+320
+00:30:56,490 --> 00:31:01,330
+الأخرى من الجينات إنها تشتغل فاحنا بنقول ما بين
+
+321
+00:31:01,330 --> 00:31:07,070
+هدولة الـ …
+
+322
+00:31:07,070 --> 00:31:13,330
+يعني ما بين هدولة الـ Two Extremes أو الـالأشياء
+
+323
+00:31:13,330 --> 00:31:18,830
+المطرفة كثير إنه 100% قد بعض إثنين أو 100% بس واحد
+
+324
+00:31:18,830 --> 00:31:24,530
+والتاني صفر يعني ما بين خمسين وخمسين وصفر ومية في
+
+325
+00:31:24,530 --> 00:31:29,630
+مرات حالات بتكون Unbalanced يعني الـ gene بيشتغل
+
+326
+00:31:29,630 --> 00:31:33,530
+ثمانين و الـ gene بيشتغل عشرين يعني هيك كلمة
+
+327
+00:31:33,530 --> 00:31:38,930
+Genomic Imprint لا والله ماني فاهمها مش هي اللي
+
+328
+00:31:38,930 --> 00:31:44,990
+مقصودة هنايعني القصد في الموضوع هذا إنه فيه آليات
+
+329
+00:31:44,990 --> 00:31:50,890
+للتحكم في الـ Transcription بحيث إنه ممكن في ظواهر
+
+330
+00:31:50,890 --> 00:31:56,090
+تكون أثنين تماماً شغلين و أثنين على أقصى سرعة
+
+331
+00:31:56,090 --> 00:32:00,950
+شغلين وأحياناً بيكون واحد بيشغل 100% والثاني صفر
+
+332
+00:32:00,950 --> 00:32:08,290
+فهذه موجودة وهدولة يعني بدنا نفهمهم كظواهريا إما
+
+333
+00:32:08,290 --> 00:32:11,330
+بكون عندي Balanced Expression، يا إما Unbalanced
+
+334
+00:32:11,330 --> 00:32:15,070
+Expression، يا إما Monoallelic Expression والـ
+
+335
+00:32:15,070 --> 00:32:19,690
+Monoallelic Expression هي الـ Parental Germline
+
+336
+00:32:19,690 --> 00:32:24,470
+Genomic Imprinting هذه حاطين Epigenetic Silencing
+
+337
+00:32:24,470 --> 00:32:29,130
+Ovaries in Imprinted Region أنا الـ Imprinting ما
+
+338
+00:32:29,130 --> 00:32:38,590
+بفهمهاش، يعني بيكون تسكير عليهمالـ Monoallelic
+
+339
+00:32:38,590 --> 00:32:44,990
+Expression في الـ T-cells والـ B-cells هو بتمن
+
+340
+00:32:44,990 --> 00:32:49,730
+خلال بعدها قضية Somatic Rearrangement اللي هي قطع
+
+341
+00:32:49,730 --> 00:32:56,230
+و لسق في الـ DNA بس هاي يعني فقط في الـ T-cells
+
+342
+00:33:01,370 --> 00:33:08,590
+مرة ثانية لما نقول «mono
+
+343
+00:33:08,590 --> 00:33:11,370
+expression» أو «balanced expression» أو
+
+344
+00:33:11,370 --> 00:33:16,910
+«imbalanced expression» التفكير الأول هيك أنه
+
+345
+00:33:16,910 --> 00:33:21,070
+الأصل أننا جينين نصف اختين منهم الأصل أنه فنتان
+
+346
+00:33:21,070 --> 00:33:26,070
+يشتغلوا وهي أحيانًا بتحدث فبتكون أنه في فنتان
+
+347
+00:33:26,070 --> 00:33:32,550
+شغلها بس أحيانًا أخرىبكون لمستوى إنه بس نسخة واحدة
+
+348
+00:33:32,550 --> 00:33:37,050
+هي اللي تشتغل يعني هنا فقط الأزرق هو الشغال الجين
+
+349
+00:33:37,050 --> 00:33:40,890
+التاني اللي موجود على الـ Chromosome الأحمر مالوش
+
+350
+00:33:40,890 --> 00:33:46,830
+أي دور أو فعلية في الجسم، في خلايا معينة، في جينات
+
+351
+00:33:46,830 --> 00:33:52,410
+محددة، في حالات معينة بتلاقي هذا الظاهر اللي بتصير
+
+352
+00:33:52,410 --> 00:33:57,190
+إنه كلها بس جين واحد، نسخة واحدة هي اللي شغالة،
+
+353
+00:33:57,190 --> 00:34:01,630
+التاني مش شغالةوأحيانًا أثنين شغلات قد بعض
+
+354
+00:34:01,630 --> 00:34:07,330
+وأحيانًا واحدة أكتر من الثانية ما أظن أنها مش صعبة
+
+355
+00:34:07,330 --> 00:34:13,970
+يعني ماشي الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+356
+00:34:13,970 --> 00:34:13,970
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+357
+00:34:13,970 --> 00:34:19,990
+الـ الـ الـ الـ
+
+358
+00:34:19,990 --> 00:34:23,670
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+359
+00:34:23,670 --> 00:34:24,830
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+360
+00:34:24,830 --> 00:34:26,430
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+361
+00:34:26,430 --> 00:34:26,430
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+362
+00:34:26,430 --> 00:34:27,450
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الوأي
+
+363
+00:34:27,450 --> 00:34:33,350
+إنسان عنده Two قليل من الممكن يعني مثلا الـ ABO
+
+364
+00:34:33,350 --> 00:34:41,610
+System فيله تلاتة قليل يا A يا B يا O وبالتالي لما
+
+365
+00:34:41,610 --> 00:34:47,630
+يكون عند إنسان AB إثنين شغلات ماشي لما يكون عنده
+
+366
+00:34:47,630 --> 00:34:52,230
+AO الـ A شغال الـ O مش شغال أصلا مافيش فيه إشي
+
+367
+00:34:52,230 --> 00:34:56,270
+يعنيفمافيش إيش ناتج منه هذا بدنا نسميه Unbalanced
+
+368
+00:34:56,270 --> 00:34:59,330
+Expression الأول اللي هو الـ Mono أقل لك إذا كان
+
+369
+00:34:59,330 --> 00:35:05,450
+AB إذا كان AO أما إن إذا الأصل AB إثنين Co
+
+370
+00:35:05,450 --> 00:35:08,750
+-dominant إثنين زي بعض بيشتغلوا فبيبين الـ A
+
+371
+00:35:08,750 --> 00:35:15,290
+وبيبين الـ B ماشي للـ X-Chromosome أنا اللي كنت
+
+372
+00:35:15,290 --> 00:35:19,350
+ناوي يعني كنت قاعد بحكي اللي هو بالنسبة للـ X
+
+373
+00:35:19,350 --> 00:35:26,070
+-Chromosome بالذاتبتلاقي أحيانًا الـ Infant الـ
+
+374
+00:35:26,070 --> 00:35:31,730
+Female اللي هي XX الأصل أنه يكون حتى لو عندها
+
+375
+00:35:31,730 --> 00:35:38,550
+Disease جين نسخة واحدة و Recessive الأصل أنها ما
+
+376
+00:35:38,550 --> 00:35:43,210
+يظهر عليها شيء لأنها Career لأن عندها ثاني شغال بس
+
+377
+00:35:43,210 --> 00:35:50,110
+حقيقة برغم أنه لو ال disease X-linked Recessive
+
+378
+00:35:50,820 --> 00:35:55,460
+بالرغم من أنه Recessive ويعني
+
+379
+00:35:55,460 --> 00:35:59,580
+الأصل بما أن أنا عنده نسخة تانية شغالة طبيعية
+
+380
+00:35:59,580 --> 00:36:05,220
+كويسة بتلاقيها بعض النساء عندهم ضواهر للمرض يعني
+
+381
+00:36:05,220 --> 00:36:12,260
+المتنحي اشتغل السبب أنه بيصير عندي Random X
+
+382
+00:36:12,260 --> 00:36:16,140
+-Chromosome Inactivation هذه ظاهرة بتحدث أنه
+
+383
+00:36:16,140 --> 00:36:21,280
+بطريقة عشوائيةالخلية بتقرر إن واحد من هالـ X
+
+384
+00:36:21,280 --> 00:36:25,600
+-Chromosomes بدنا ما نستخدموه، خلاص نستخدم واحد
+
+385
+00:36:25,600 --> 00:36:31,320
+معين طبعاً بتستخدمه لكل شيء فبقول لما نستخدمه لكل
+
+386
+00:36:31,320 --> 00:36:37,880
+شيء وكون هو المرض فيه كـ Recessive gene Recessive
+
+387
+00:36:37,880 --> 00:36:44,340
+trait، ظاهرة متنحية بتلاقيها تظهر فهي بتفسر ليش
+
+388
+00:36:44,340 --> 00:36:51,450
+أحياناً بعض الأمراضاللي حتى لو كان المرض مثنحي
+
+389
+00:36:51,450 --> 00:36:55,170
+والـ Female Carrier الأصل لأنه ما يظهر عليها شيء
+
+390
+00:36:55,170 --> 00:36:59,390
+بيتكون أنت بعض مظاهر المرض وهي تحدث في الـ Area of
+
+391
+00:36:59,390 --> 00:37:06,390
+Embryogenesis يعني هنا اللي بدي تكون تخرجه فيه أنه
+
+392
+00:37:06,390 --> 00:37:14,410
+صحيح عندي أنا كروموزومات و DNA وبنتج عنه RNAوبنتج
+
+393
+00:37:14,410 --> 00:37:36,070
+عنه بعدين بروتيل بس بس فيه نقطة
+
+394
+00:37:36,070 --> 00:37:43,570
+الأخيرة من قبل أنا على الأقلفي غالبية الجينات قد
+
+395
+00:37:43,570 --> 00:37:51,510
+تكون مثلًا نسخة واحدة فقط منها أحيانًا بعض الجينات
+
+396
+00:37:51,510 --> 00:37:57,450
+بيكون أكثر من نسخة من هذا الـGene يعني مثلًا
+
+397
+00:37:57,450 --> 00:38:01,870
+الـAlpha Chain تبع الـHemoglobin اللي مع الـBeta
+
+398
+00:38:01,870 --> 00:38:08,690
+Globin بيعطينا الـHemoglobin كاملكجين فيه له
+
+399
+00:38:08,690 --> 00:38:14,170
+نسختين على كل كروموزوم وبالتالي Total في أي خلية
+
+400
+00:38:14,170 --> 00:38:21,990
+بيكون فيه أربعة ماشي أو أحيانًا أثنين أو أقل أو
+
+401
+00:38:21,990 --> 00:38:28,590
+أكتر يعني أو أكتر فالآن دايما مش أنه دايما الأثنين
+
+402
+00:38:28,590 --> 00:38:34,520
+الأثنين بيشتغلوا زي بعض بيلاحظ أنهفيه ظواهر إن
+
+403
+00:38:34,520 --> 00:38:41,960
+الخلايا بتكون تشتغل بشكل مش متكافئ من النسختين
+
+404
+00:38:41,960 --> 00:38:46,200
+والنسختين هدولة زي ما اتفقنا بتكون واحدة من الأب
+
+405
+00:38:46,200 --> 00:38:51,760
+وواحدة من الأم ففي أحيانًا النسختين بيشتغلوا
+
+406
+00:38:51,760 --> 00:38:58,260
+تمامًا يعني مثلًا الـ AB blood group الـ locus للـ
+
+407
+00:38:58,260 --> 00:39:03,070
+blood group اللي ABO system بنسميهاللي هو على قلته
+
+408
+00:39:03,070 --> 00:39:07,470
+قليل A وB وإذا إنسان عنده A وB وواحد من الأب وواحد
+
+409
+00:39:07,470 --> 00:39:11,330
+من الأم إثنين بيشتغلوا بيشتغلوا مائة بالمائة قد
+
+410
+00:39:11,330 --> 00:39:20,810
+بعد يعني خمسين وخمسين هاي جهة وبتحدث في المقابل في
+
+411
+00:39:20,810 --> 00:39:25,870
+أحيانًا دواهر بتكون عندى ماشية في نسختين أو أربعة
+
+412
+00:39:25,870 --> 00:39:33,130
+من الـGene بس بتكون فقط ده واحد شغالةزي ما حكينا
+
+413
+00:39:33,130 --> 00:39:37,050
+في حكاية الـ Immunoglobulin الـ Immunoglobulin الـ
+
+414
+00:39:37,050 --> 00:39:41,830
+Light Chain فيه أربعة كتب للجينات بس كل B
+
+415
+00:39:41,830 --> 00:39:46,330
+-Lymphocyte بتكون بس واحدة شغالة كل البقية
+
+416
+00:39:46,330 --> 00:39:50,890
+مابيشتغلوش فبيصير هذا نوع من الـ Unbalanced
+
+417
+00:39:50,890 --> 00:39:57,630
+Expression Unbalanced Expressionما بين هدول
+
+418
+00:39:57,630 --> 00:40:05,270
+الحالات الطرفية كثيرة يعني يا أما خمسين بالمية
+
+419
+00:40:05,270 --> 00:40:10,490
+خمسين بالمية شغل يا أما صفر ومية بالمية شغل بتلاقي
+
+420
+00:40:10,490 --> 00:40:17,150
+فيه نسب تيجي بالنص ممكن من مصدر أشرين بالمية ومن
+
+421
+00:40:17,150 --> 00:40:20,870
+مصدر تمانين بالمية ممكن من مصدر سبعين بالمية ومن
+
+422
+00:40:20,870 --> 00:40:26,720
+مصدر تلاتين بالمية ففيه دايما فروقات في عمليةتشغيل
+
+423
+00:40:26,720 --> 00:40:32,800
+وتوظيف الـ DNA وهذا بيبين على مستوى الـ RNA يعني
+
+424
+00:40:32,800 --> 00:40:37,040
+أنا صحيح إن سكتين موجودات على مستوى الـ DNA بس مش
+
+425
+00:40:37,040 --> 00:40:40,940
+بالضرورة أثنانهم يشتغلوا وهذا تتدخل في دواهر زي
+
+426
+00:40:40,940 --> 00:40:46,620
+الـ Ionization اللي هو الـ X-linked deactivation
+
+427
+00:40:46,620 --> 00:40:50,860
+أو اللي حكينا عنها اللي بيصير بالنسبة للـ females
+
+428
+00:40:50,860 --> 00:40:55,560
+بعض خلايا الـ females وشرحناها والثاني
+
+429
+00:41:10,310 --> 00:41:17,250
+الآن اللي بنتكلم عنه حتى الواحد يعني يفهم تحفيظ
+
+430
+00:41:17,250 --> 00:41:25,750
+هذا الموضوع مش غلط يعني حتى يفهم كيف البشرية يعني
+
+431
+00:41:25,750 --> 00:41:31,180
+أفضلبدرجة بصعوبة كبيرة استطعنا نعرف نقرأ التسعة
+
+432
+00:41:31,180 --> 00:41:40,860
+مليارات حرف تبع الـ DNA وصوّناها الآن الإنسان أو
+
+433
+00:41:40,860 --> 00:41:48,100
+العالم أو الطبيب أو الباحث أو كده بإمكانه أنه يعني
+
+434
+00:41:48,100 --> 00:41:54,760
+يدرس أي جيل ويكون عندنا reference المرجع الأساسي
+
+435
+00:41:55,280 --> 00:41:59,060
+أستفيد منه من خلاله عشان أفهم شو الاختلافات
+
+436
+00:41:59,060 --> 00:42:06,200
+بتذكروا أنه الـ Human Genome Project اللي بدناه
+
+437
+00:42:06,200 --> 00:42:14,520
+كان أنه درسنا الـ DNA تبع إنسان معين فحتى يعني
+
+438
+00:42:14,520 --> 00:42:19,520
+الواحد يعرف يتعامل مع هذه الجوانب كلها لازم يكون
+
+439
+00:42:19,520 --> 00:42:23,200
+عنده آلية لـ
+
+440
+00:42:25,040 --> 00:42:30,460
+لاستفادة من المعلومات اللي بتيجي من دراسات الـ
+
+441
+00:42:30,460 --> 00:42:36,820
+Sequencing اللي هو عملية يعني قراءة الـ
+
+442
+00:42:36,820 --> 00:42:41,280
+Nucleotides على مستوى الـ DNA أو الـ RNA أو
+
+443
+00:42:41,280 --> 00:42:48,760
+البروتين حتى واحنا دايماً يعني هذا الجانب هنا بعض
+
+444
+00:42:48,760 --> 00:42:55,580
+المراجع من مصادر مختلفة الأصل لما واحديقوم مثلًا
+
+445
+00:42:55,580 --> 00:42:59,780
+عنده شاف عائل مريض أو درس الـ Sequence تبعها أو
+
+446
+00:42:59,780 --> 00:43:05,380
+كان إنسان مريض عنده جانب معين وأجى درسله الموضوع
+
+447
+00:43:05,380 --> 00:43:09,540
+هذا النقاط
+
+448
+00:43:09,540 --> 00:43:16,800
+هذه بتكون من خلال إنك أنت اللي طلعته من الإنسان
+
+449
+00:43:16,800 --> 00:43:22,280
+هذا أو من المريض هذا أو من العائل المريضة هذهأقوم
+
+450
+00:43:22,280 --> 00:43:30,080
+وأشوف شو هي الـ References للقطع هذه، شو بيحكوا
+
+451
+00:43:30,080 --> 00:43:35,480
+الموجود ففي الـ Human Genome Project في الـ
+
+452
+00:43:35,480 --> 00:43:39,420
+Database تبعت الـ SNPs اللي هو Single Nucleotide
+
+453
+00:43:39,420 --> 00:43:46,220
+Polymorphism اللي هو يعني أنه جزء من الموضوعقضية
+
+454
+00:43:46,220 --> 00:43:52,100
+إنه اللي صرفوا على كثير من الأبحاث بالذات اللي مش
+
+455
+00:43:52,100 --> 00:43:59,200
+بشكل تجاري زي الحكومات أو الجامعات أو كده بتلاقيهم
+
+456
+00:43:59,200 --> 00:44:03,520
+بتطلبوا إنه هذه المعلومة تكون مشاركة مع الجميع
+
+457
+00:44:03,520 --> 00:44:08,620
+يعني ما يكون هي ملك فقط للباحث بحيث يخبّي عليها
+
+458
+00:44:08,620 --> 00:44:14,240
+ومايعطيها لحد تاني فبطلبوا إنه كل الناس تشارك في
+
+459
+00:44:14,240 --> 00:44:20,340
+إنه تحطالترتيب الـ Nucleotides اللي طلعتها وترتيب
+
+460
+00:44:20,340 --> 00:44:24,800
+الـ Amino Acids والبروتين اللي طلعوا والـ RNA اللي
+
+461
+00:44:24,800 --> 00:44:30,940
+طلعوا فأهم مرجع للمصادر العلمية الآن إذا واحد بده
+
+462
+00:44:30,940 --> 00:44:36,040
+يدرس أي موضوع تعرفه اللي هو الـ PubMedالـ PubMed
+
+463
+00:44:36,040 --> 00:44:42,520
+موضع في ولايات المتحدة الأمريكية ومحطين فيه الـ
+
+464
+00:44:42,520 --> 00:44:51,200
+DNA والـ RNA والبروتين وكذا ويعني نتذكر يعني من
+
+465
+00:44:51,200 --> 00:44:56,380
+سبب أنه في عندي 64 من الـ Nucleotide Sequence حتى
+
+466
+00:44:56,380 --> 00:45:01,680
+يعمل الـ 20 Mino Acids لإنه فيه اشتراكات يعني
+
+467
+00:45:01,680 --> 00:45:07,340
+أحيانًا الـ SNAP هذهمالهاش قيمة، ما هي بتساعدنا أن
+
+468
+00:45:07,340 --> 00:45:12,240
+نشوف من وين أجى هذا الـ DNA من الأب، من الأم، هل
+
+469
+00:45:12,240 --> 00:45:16,760
+صار فيه تغير معين ولا لأ، أو أنه بس على مستوى الـ
+
+470
+00:45:16,760 --> 00:45:22,200
+Protein قد لا يكون له قيمة يعني، فهنا مجموعة مراجع
+
+471
+00:45:22,200 --> 00:45:27,960
+حتى الواحد لو طلع إشي يشوف بشبه إيش حد اكتشفه من
+
+472
+00:45:27,960 --> 00:45:32,340
+قبل، وأحيانًا هذه المراجع مش بس للـ Human Genetic
+
+473
+00:45:32,340 --> 00:45:38,500
+Diversityفي أول Whole-Genome Sequencing كان لذبابة
+
+474
+00:45:38,500 --> 00:45:43,940
+الفاكهة أو لحيوانات أخرى أو الـ بيروسات والبكتيريا
+
+475
+00:45:43,940 --> 00:45:51,340
+والنباتات وكذا ففي قواعد بيانات الـ Databases
+
+476
+00:45:51,340 --> 00:45:56,820
+بيكون فيها كل المعلومات الوراثية لكل المُركّبات
+
+477
+00:45:56,820 --> 00:46:02,820
+اللي نعرف عنها سواء Human وNon-Human وبالتالتبس
+
+478
+00:46:02,820 --> 00:46:07,300
+إحنا لما نيجي نتعامل إنه أنا والله عندى عائلة
+
+479
+00:46:07,300 --> 00:46:13,600
+مريضة أخدت الـ DNA منهم درست شو الترتيب الـ
+
+480
+00:46:13,600 --> 00:46:18,360
+Sequence سبعتهم فوق الـ PCR وعرفت الترتيب ممكن
+
+481
+00:46:18,360 --> 00:46:25,100
+أقارنه بـ Database يعنيلما نقول Diversity
+
+482
+00:46:25,100 --> 00:46:31,720
+وVariation بنبدأ بإنه في أشياء شائعة منهم مثلًا
+
+483
+00:46:31,720 --> 00:46:36,320
+اللي هي SNP اللي هي Single Nucleotide Polymorphism
+
+484
+00:46:36,320 --> 00:46:43,800
+يعني إنه بس حرف واحد على مستوى الـ DNA وكل ثلاث
+
+485
+00:46:43,800 --> 00:46:48,840
+أحرف تعطينا أمينو أسد واحد فـ Single Nucleotide
+
+486
+00:46:51,050 --> 00:46:56,530
+وPolymorphism تغيير بس واحد من الـ Base Pair وهذا
+
+487
+00:46:56,530 --> 00:47:02,430
+عادةً ممكن مايكونش له قيمة بس ممكن يكون عندي ظاهرة
+
+488
+00:47:02,430 --> 00:47:08,370
+أكتر من الـ Base Pair واحد لحد مية نسميه Insertion
+
+489
+00:47:08,370 --> 00:47:13,790
+وDeletion أحيانًا فيه Copy Number Variation يعني
+
+490
+00:47:13,790 --> 00:47:20,370
+قضية راح ناخد مثلًا بالهيموفيلياعبارة عن إذا في
+
+491
+00:47:20,370 --> 00:47:24,910
+هيموفيليا اللي أخذ الـ «ثلاثيميا» في Alpha و Beta
+
+492
+00:47:24,910 --> 00:47:28,730
+إذا تبعات الـ Alpha هي Copy Number Variation
+
+493
+00:47:28,730 --> 00:47:35,750
+فبتلاقي قطعة كبيرة أكبر من يعني عشر تلاف Base عشر
+
+494
+00:47:35,750 --> 00:47:40,710
+تلاف كيلو Base أو مليون One Mega Base أو قضية إنه
+
+495
+00:47:40,710 --> 00:47:46,630
+يصير Inversion يعني إنه نتيجة لفة الـ DNA إن حطت
+
+496
+00:47:46,630 --> 00:47:53,060
+طريقة مختلفةهي أنواع الـ Variations اللي ممكن مرات
+
+497
+00:47:53,060 --> 00:48:01,440
+تحدث هي تشبه من اللي حاطنناها مرة من قبل أنه هي
+
+498
+00:48:01,440 --> 00:48:06,920
+عندي Different Sequence في قطعة معينة بشتغل عليها
+
+499
+00:48:06,920 --> 00:48:11,580
+إذا كان زي هيك هذا الإنسان عنده القليل الأول
+
+500
+00:48:11,580 --> 00:48:17,830
+والثانيالأليلين زي بعض بس في واحد هذا عنده Snaps
+
+501
+00:48:17,830 --> 00:48:24,810
+هاي بدنا نسميها هنا اللي هي deletion أو insertion
+
+502
+00:48:24,810 --> 00:48:32,230
+هنا اللي بنلاحظه شوفوا هدولة هذا الأليل الأول اللي
+
+503
+00:48:32,230 --> 00:48:35,710
+هو بيشبه ال reference اللي صار هنا صار عندي
+
+504
+00:48:35,710 --> 00:48:42,030
+insertion يعني هاي أجت الزيادة فالـ Tكانت هنا
+
+505
+00:48:42,030 --> 00:48:49,510
+مفروض تجيب ورا الـ G ثم A ثم A ثم C ثم T ثم كده
+
+506
+00:48:49,510 --> 00:48:57,770
+فهذا النوع بدنا نسميه Indel صحيح A بس هو حقيقة هو
+
+507
+00:48:57,770 --> 00:49:02,650
+insertion single nucleotide طبعا هذا بيخرّب الدنيا
+
+508
+00:49:02,650 --> 00:49:08,220
+الـ SNP في الغادر ما راح يعمل أي شيء لأنهيمكن مرات
+
+509
+00:49:08,220 --> 00:49:12,000
+كثيرة أنه بتكون نفس البروتين بالتالي مش ضروري أن
+
+510
+00:49:12,000 --> 00:49:17,120
+يكون له تأثير بس أحياناً طبعاً بيأثر هنا هذا
+
+511
+00:49:17,120 --> 00:49:23,320
+بيسموه لما يكون insertion لواحد راح يخرّب كل ال
+
+512
+00:49:23,320 --> 00:49:29,080
+copy هذه راح تكون لأنه نقرأ ثلاث ثلاث ثلاث لما تحط
+
+513
+00:49:29,080 --> 00:49:33,840
+واحد زيادة راح تخرّب الثلاثيات أما لو صارالـ
+
+514
+00:49:33,840 --> 00:49:37,260
+insertion لثلاثة ممكن ما يكونش إيها تأثير كبير
+
+515
+00:49:37,260 --> 00:49:41,640
+لأنه بالأخير بيظل البروتين ممكن انتاجه من هذا الـ
+
+516
+00:49:41,640 --> 00:49:48,240
+DNA هنا صار عملية deletion،
+
+517
+00:49:48,240 --> 00:49:52,360
+deletion لإثنين لما يكون إثنين الـ deleted يعني
+
+518
+00:49:52,360 --> 00:49:57,300
+أنا هنا هاي تمام زي البقية هذولة الـ T والـ T طال
+
+519
+00:49:57,300 --> 00:50:03,520
+الـ C صارت تشبك ورا الـ T والبقية بنزل زي ما هو
+
+520
+00:50:04,370 --> 00:50:08,090
+فالأصل كان يعني عملوا زي هنا الـ Rectare Deletion
+
+521
+00:50:08,090 --> 00:50:13,770
+حطوا هاي ورا هاي على طول وجرّوا البقية فهذه أنواع
+
+522
+00:50:13,770 --> 00:50:22,570
+من بعض الـ Polymorphisms اللي بنشوفها فالـ
+
+523
+00:50:22,570 --> 00:50:25,750
+غير
+
+524
+00:50:25,750 --> 00:50:30,050
+الـ SNP حكينا
+
+525
+00:50:30,050 --> 00:50:36,140
+Single أو Limited يا إماinsertion أو deletion
+
+526
+00:50:36,140 --> 00:50:42,380
+أحياناً هنا copy number variant يعني أنا هنا FG
+
+527
+00:50:42,380 --> 00:50:50,740
+مرة واحدة قطيت FG FG FG طبعاً هنا يعني على مستوى
+
+528
+00:50:50,740 --> 00:51:02,000
+الجينات كلها ناشي يعني أنا بدل القليل الأولالـ «H»
+
+529
+00:51:02,000 --> 00:51:05,860
+هنا وبعدين «G» «F» يعني «A» «B» «C» «D» «E» «F»
+
+530
+00:51:05,860 --> 00:51:12,860
+«G» هذا على مستوى الجين كله فأحياناً في إنسان غير
+
+531
+00:51:12,860 --> 00:51:18,100
+إنسان ثاني إنه هنا بيصير ثلاثي copy بدل ما هي واحد
+
+532
+00:51:18,100 --> 00:51:23,600
+اللي كان لازم تكون وفي inverse polymorphism إذا
+
+533
+00:51:23,600 --> 00:51:28,220
+كان عندي مثلا ترتيب الجينات «A» «B» «C» «D» «E»
+
+534
+00:51:28,220 --> 00:51:33,200
+«F» «G» «H» كدهصار قطع ولسف بطريقة غلط بحيث أنه
+
+535
+00:51:33,200 --> 00:51:39,020
+صار AB بعدين EDC هنا الله عليه يعلم يعني مايكونش
+
+536
+00:51:39,020 --> 00:51:43,780
+تأثير كبير على الوظيفة بقدر ما أنه على مستوى الـ
+
+537
+00:51:43,780 --> 00:51:47,880
+DNA فيه اختلافات، Polymorphism Micro-satellite
+
+538
+00:51:47,880 --> 00:51:52,680
+polymorphism هي تكرار
+
+539
+00:51:52,680 --> 00:51:56,180
+لمجموعات معينة وMobile element insertion
+
+540
+00:51:56,180 --> 00:52:01,540
+polymorphismبغيّر تفتيح خيفقرات الـ DNA وأشياء
+
+541
+00:52:01,540 --> 00:52:06,000
+مختلفة فيه
+
+542
+00:52:06,000 --> 00:52:12,280
+يعني هذه الظواهر اليوم بنوقف لهذه اللحظة أنا آسف
+
+543
+00:52:12,280 --> 00:52:18,660
+اليوم خربطة من عندي بس إن شاء الله المرة اللي جاي
+
+544
+00:52:18,660 --> 00:52:22,340
+بنراجع الأشياء وده فيه أسئلة وجروب الـ WhatsApp
+
+545
+00:52:22,340 --> 00:52:25,480
+فاتحة يعني
+
+546
+00:52:27,390 --> 00:52:32,210
+إذا حد عنده أسئلة ممكن نتناقش فيها يعطيكم العافية
+
+547
+00:52:32,210 --> 00:52:37,270
+السلام عليكم السلام ورحمة الله يعطيك العافية مش
+
+548
+00:52:37,270 --> 00:52:39,770
+عارف إذا دكتورة ده كنت سامعني لأ لكن عموما يعطيك
+
+549
+00:52:39,770 --> 00:52:43,650
+العافية يعطيكم العافية يا دكاترا وإن شاء الله يعني
+
+550
+00:52:43,650 --> 00:52:47,270
+إلى لقاءة قادمة بإذن الله السلام عليكم يعطيكم
+
+551
+00:52:47,270 --> 00:52:47,650
+العافية
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/hUu77dlYhF8_postprocess.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/hUu77dlYhF8_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..a3c425f915205d4adac875f89c094170be2a4b0a
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/hUu77dlYhF8_postprocess.srt
@@ -0,0 +1,3785 @@
+1
+00:00:06,510 --> 00:00:13,430
+بسم الله الرحمن الرحيم أهياركم الله ونبدأ إن شاء
+
+2
+00:00:13,430 --> 00:00:18,950
+الله المحاضرة فبنبدأ نسأل في أي حد عنده استفسار عن
+
+3
+00:00:18,950 --> 00:00:27,230
+النقاط اللي قبل؟ في أي أسئلة؟ في أي شيء؟ إحنا إن
+
+4
+00:00:27,230 --> 00:00:33,570
+شاء الله يوم الجمعة هيكون chapters تمانية وتسعة أو
+
+5
+00:00:33,570 --> 00:00:38,990
+عشرة أو أحداشرأنا مش ذاكر فصل تمانية دخلناها بالـ
+
+6
+00:00:38,990 --> 00:00:43,210
+mid-term quiz يا دكتور أحمد و اللي ما دي كانش داخل
+
+7
+00:00:43,210 --> 00:00:47,870
+طنيت أنه دقلناها صحيح هو أيام حطيت عليه أكتر من
+
+8
+00:00:47,870 --> 00:00:51,850
+سؤال انت قلتلي لسه ما .. يعني ما .. بحكي .. السؤال
+
+9
+00:00:51,850 --> 00:00:57,050
+الأسئلة ما شملتش كل ال chapter طيب طيب إن شاء الله
+
+10
+00:00:57,050 --> 00:01:01,410
+فعشان هيك أنا قلت إذا كان في أسئلة أنت حابب تضيف
+
+11
+00:01:01,410 --> 00:01:06,370
+أو حاجة عشان ذلكإذا في حد عنده أسئلة صراحة المراجع
+
+12
+00:01:06,370 --> 00:01:10,670
+أو المراجع كلها إحنا إن شاء الله الأسبوع هذا راح
+
+13
+00:01:10,670 --> 00:01:15,850
+نخلص الكتاب بالناحية الفصول اللي فيها مواضيع أما
+
+14
+00:01:15,850 --> 00:01:22,090
+بيظل جوانب العلم بالنسبة لتفاصيل الأمراض هذه
+
+15
+00:01:22,090 --> 00:01:27,550
+مستحيل تطلب اليوم أو تكون هيك يعني بالتفاصيل
+
+16
+00:01:27,550 --> 00:01:33,940
+المطلوبة بقدرلأن هذه بتكون يعني بدّوا الواحد سنين
+
+17
+00:01:33,940 --> 00:01:37,800
+وبدّوا الواحد خبرة وبدّوا الواحد يكون شاف الحالات
+
+18
+00:01:37,800 --> 00:01:42,360
+يعني حتى يستوعبها تماماً في أشياء موجودة عندنا وهي
+
+19
+00:01:42,360 --> 00:01:46,580
+لازم الواحد يركز عليها بس في أحيانا مبادئ في
+
+20
+00:01:46,580 --> 00:01:49,040
+الوراثة
+
+21
+00:01:49,600 --> 00:01:56,720
+بتلاقيها موضّحة أكثر بأمثلة في مجموعات
+
+22
+00:01:56,720 --> 00:02:00,620
+بشرية أخرى يعني مش ضروري علنا يعني بس يمكن الواحد
+
+23
+00:02:00,620 --> 00:02:09,780
+مهم أنه يشوفها عشان يعني موضوع أنه يكون يعني يطلع
+
+24
+00:02:09,780 --> 00:02:16,120
+على المفهوم الطبي العلمي الوراثي اليوم احنا راح
+
+25
+00:02:16,120 --> 00:02:22,490
+ناخد الفصل 18وإن شاء الله نهاية اليوم الأربعة ندخل
+
+26
+00:02:22,490 --> 00:02:26,870
+آخر موضوع وموضوع مهم جداً أخلاقيات الوراتة،
+
+27
+00:02:26,870 --> 00:02:31,010
+أخلاقيات التعامل مع هذه الأمراض وهذه الحالات وهذه
+
+28
+00:02:31,010 --> 00:02:36,950
+الإمكانات، وصراحة موضوع مهم اليوم راح نتكلم على
+
+29
+00:02:38,520 --> 00:02:41,400
+«personalized healthcare» أو «personalized
+
+30
+00:02:41,400 --> 00:02:50,780
+medicine» يعني الطب الفردي، الطب الشخصي أحنا يعني،
+
+31
+00:02:50,780 --> 00:02:57,760
+وهذا لبعض التطبيقات للـGenomics والـGenetics في
+
+32
+00:02:57,760 --> 00:03:05,080
+الـ«personalized healthcare» فيعني هو موضوع بصراحة
+
+33
+00:03:05,660 --> 00:03:12,220
+ممتع ويعني حتى أنا بقول بالنسبة للأردن في جانب منه
+
+34
+00:03:12,220 --> 00:03:18,020
+مطبق بس في جوانب كثيرة غير مطبقة أو لا نستطيع
+
+35
+00:03:18,020 --> 00:03:22,360
+القيام فيها بالشكل اللي الدول اللي عندها إمكانات
+
+36
+00:03:22,360 --> 00:03:27,480
+متقدمة وعندها نظم صحية بتهتم بصحة الفرد حيث كل
+
+37
+00:03:27,480 --> 00:03:33,280
+إنسان يحاولوا أنه يخلوه بأعلى درجة من الصحة الـ
+
+38
+00:03:35,700 --> 00:03:43,280
+الفكرة أنه بالنسبة للـ Personalized Medicine إنه
+
+39
+00:03:43,280 --> 00:03:48,080
+إذا في إمكانية بالإضافة للتاريخ العائلي للـ
+
+40
+00:03:48,080 --> 00:03:51,980
+History Taking والـ Family History والجوانب الأخرى
+
+41
+00:03:51,980 --> 00:03:59,750
+السريرية من كيف نأخذ تاريخ مرض من المريضإذا الواحد
+
+42
+00:03:59,750 --> 00:04:06,830
+عنده يعني خصوصاً إذا بتثبتها دراسات من قبل ممكن
+
+43
+00:04:06,830 --> 00:04:11,050
+الواحد يتلافى كثير من المشاكل زي ما بيقولوا دايماً
+
+44
+00:04:11,050 --> 00:04:16,510
+الوقاية خير من العلاج أو قنطة يعني درهم وقاية خير
+
+45
+00:04:16,510 --> 00:04:21,810
+من قطار علاج فمن الأمثلة على الأشياء المهمة
+
+46
+00:04:21,810 --> 00:04:27,570
+والقوية بهذا الموضوعمثلًا، ناخد حالة وهي للأسف
+
+47
+00:04:27,570 --> 00:04:33,630
+الأمثلة على الكثير من الأشياء والمفاهيم هذه ما
+
+48
+00:04:33,630 --> 00:04:39,350
+بتتوضح إلا من خلال مثال «بد الواحد يكون احتك بمريد
+
+49
+00:04:39,350 --> 00:04:44,430
+من هذا النوع حتى يعرف همية هذا الموضوع» فعندنا
+
+50
+00:04:44,430 --> 00:04:48,070
+مثلًا اللي هو الـ Colon Cancer «سرطان القلون»
+
+51
+00:04:48,070 --> 00:04:54,440
+«سرطان الأمعاء الغليظة»مرض؟ والله في مستشفانة
+
+52
+00:04:54,440 --> 00:04:59,440
+ومركز تحويلي ثالثي يعني مستشفى الجامعي إن حالات
+
+53
+00:04:59,440 --> 00:05:05,580
+كثيرة، بالأردن تيجي حالات كثيرة الفكرة في الموضوع
+
+54
+00:05:05,580 --> 00:05:17,960
+هذا إنه لما نحن نشوف مثل هذه النقطة إنه إذا
+
+55
+00:05:17,960 --> 00:05:23,270
+الإنسان يعني وكان عنده علمإنه على عمر الخمس
+
+56
+00:05:23,270 --> 00:05:31,570
+وثلاثين إذا الإنسان صاب سرطان قلون فهذا يضاعف
+
+57
+00:05:31,570 --> 00:05:38,470
+درجات مضاعفة كثيرة نسبة احتمالية إن الأفراد
+
+58
+00:05:38,470 --> 00:05:42,990
+العائلة للآخرين مصابين بسرطان القلون أو يصابوا
+
+59
+00:05:42,990 --> 00:05:50,770
+بسرطان القلون فهنا بيفرجونا دراسةأو نتيجة دراسة
+
+60
+00:05:50,770 --> 00:06:00,190
+معينة محددة بيفرجيكم الفرق بين نسبة
+
+61
+00:06:00,190 --> 00:06:05,170
+سرطان القلون في اللي عندهم تاريخ مرض عائلي بالنسبة
+
+62
+00:06:05,170 --> 00:06:10,630
+لهذا المرض وبين اللي ما عندهم مش بدرجات كبيرة بس
+
+63
+00:06:10,630 --> 00:06:15,370
+الفكرة إنه يكون السرطان قبل عمره الخمس وثلاثين
+
+64
+00:06:15,370 --> 00:06:24,770
+إحنا في الطب عامةًبنتكلم على إنه هناك يفضل إن يكون
+
+65
+00:06:24,770 --> 00:06:33,330
+بعض البرامج للبحث عن السرطان حسب العمر، حسب
+
+66
+00:06:33,330 --> 00:06:38,950
+الحالة، حسب النوعية، حسب المجموعة البشرية الـ
+
+67
+00:06:38,950 --> 00:06:45,090
+Population اللي عندنا إياها فهذه دايماً جانب لازم
+
+68
+00:06:45,090 --> 00:06:50,530
+الواحد يهتم فيهفإذا كان يعني عادةً إحنا سلطان
+
+69
+00:06:50,530 --> 00:06:55,290
+القلون نقعد إنه بنسوي Screening عليه مرات إذا
+
+70
+00:06:55,290 --> 00:06:59,370
+بيعملوها فإنه أنا شخصياً يعني في مستشفانة وأنا لست
+
+71
+00:06:59,370 --> 00:07:04,910
+وخصائي أو رام مابنعملهاش بشكل كما هو مطلوب على سن
+
+72
+00:07:04,910 --> 00:07:09,490
+الأربعين أو الخمسين المفروض الإنسان يعني هيك اللي
+
+73
+00:07:09,490 --> 00:07:14,170
+بيقولوه يعني المفروض الإنسان أولاً يعمل فحص وراز
+
+74
+00:07:14,170 --> 00:07:18,880
+للدم الخفيوهذا بيبين إن هناك نوع من النزف أو الـ
+
+75
+00:07:18,880 --> 00:07:23,640
+«شيء» هذا بيكون إيجابي أكثر في اللي عندهم سرطان
+
+76
+00:07:23,640 --> 00:07:30,920
+قولون مفروض على سن الخمس وخمسين أو حسب الحالة ممكن
+
+77
+00:07:30,920 --> 00:07:36,860
+إنه يعمل قولون يعني أبارعاً تنظير لمعاء السفلية
+
+78
+00:07:36,860 --> 00:07:47,200
+فحص بغلب، بده تجهيز، بس بيقولوا إنه لازم ينعملفمن
+
+79
+00:07:47,200 --> 00:07:51,500
+أهم المجموعات اللي احنا لازم نركز على هذا الموضوع
+
+80
+00:07:51,500 --> 00:07:59,600
+لأنه صراحة أي مشكلة، يعني أنا بضرب مثال المرضة
+
+81
+00:07:59,600 --> 00:08:03,500
+في مرض اسمه «Alterative Colitis» اللي هو التهاب
+
+82
+00:08:03,500 --> 00:08:09,300
+القلون التقرحي نسبة عالية جدا بعد عشر سنوات من
+
+83
+00:08:09,300 --> 00:08:13,940
+أصابتهم بهذا المرض يصابوا بمضاعفات اللي يصبح لديهم
+
+84
+00:08:13,940 --> 00:08:21,270
+سلطان في القلونبعض الأشياء التي حتى قبل أن تصبح
+
+85
+00:08:21,270 --> 00:08:25,970
+مضاعفات أخرى غير هذا الموضوع بس أهم شيء لخطر
+
+86
+00:08:25,970 --> 00:08:31,450
+السرطان ينصح بإزالة القلون بأكمله يعني الواحد يعيش
+
+87
+00:08:31,450 --> 00:08:36,730
+من غير قلون، يعني حياته غلبهويكون عنده Divergent
+
+88
+00:08:36,730 --> 00:08:41,930
+Colostomy ويكون عنده فتحة جانبية للإخراج وكذا يعني
+
+89
+00:08:41,930 --> 00:08:47,430
+مش منظر ولا عيشة بس أحسن من الوفاة بالسلطان، سلطان
+
+90
+00:08:47,430 --> 00:08:54,710
+القلون فهناك نقاط كثيرة، بس الفكرة إنه إذا أنا
+
+91
+00:08:54,710 --> 00:08:59,530
+أتعامل مع إنسان لديه قريب من الدرجة الأولى عنده
+
+92
+00:08:59,530 --> 00:09:05,470
+سلطان القلون، أنا يجب أن يعنيأنتبه لهذا الجانب
+
+93
+00:09:05,470 --> 00:09:11,770
+وأدور عليه بحيث أنه ألقط السلطان هو لسه في المرحلة
+
+94
+00:09:11,770 --> 00:09:16,610
+الأولى وإذا بحتاج أشيل نص القلون أو ربع القلون أو
+
+95
+00:09:16,610 --> 00:09:22,850
+كل القلون بشيله يعني بعيش المريض ويكون الأمر أفضل
+
+96
+00:09:22,850 --> 00:09:28,200
+فهذا يعني جانبلو أنا انتبهت إلها في تاريخ المرض
+
+97
+00:09:28,200 --> 00:09:32,460
+يتبع مريضي كان أنا يجب أن أتعامل معاه بشكل مختلف
+
+98
+00:09:32,460 --> 00:09:39,360
+بدي أتعامل معاه بطريقة أخرى فبالنسبة
+
+99
+00:09:39,360 --> 00:09:43,900
+للموضوع الثاني فهذا مثال على Personalized Medicine
+
+100
+00:09:43,900 --> 00:09:47,840
+أنا لو أجاني إنسان طبيعي عادي ماعنده أي تاريخ مرضي
+
+101
+00:09:47,840 --> 00:09:52,440
+لـ سلطان القلونالمفروض أنه يعملوا بشكل مختلف، بس
+
+102
+00:09:52,440 --> 00:09:57,220
+لو كان عنده هذه المشكلة
+بتكون لها ناحية مهمة
+
+103
+00:09:57,220 --> 00:10:05,900
+المبدأ الثاني اللي بتكلم عليه الفصل هذا بمحاولة
+
+104
+00:10:05,900 --> 00:10:13,360
+التفريد وجعل الطبمناسب لكل فرد بحد ذاته حسب تاريخه
+
+105
+00:10:13,360 --> 00:10:19,240
+العائلي ووراثته وجوانب في حياته أو في الوراثة
+
+106
+00:10:19,240 --> 00:10:26,320
+تبعته إنه أنا أدور على الأمراض حتى يعني على فترة
+
+107
+00:10:26,320 --> 00:10:36,000
+على عمر صغير ومن أولها من مرحلة الولادة يعني في
+
+108
+00:10:36,000 --> 00:10:40,770
+الولايات المتحدة الأمريكية وهذا الجدول منههناك
+
+109
+00:10:40,770 --> 00:10:47,630
+مجموعة من الأمراض يعني إلها حظ وافر من نسبة إنه
+
+110
+00:10:47,630 --> 00:10:55,030
+يكون الإنسان يولد فيها فمنها الحطي رقم واحد الـ
+
+111
+00:10:55,030 --> 00:10:59,190
+Conjugate اللي هي Hearing Loss طبعاً هنا حاطينه
+
+112
+00:10:59,190 --> 00:11:06,220
+200 حالة لكل 100 ألف مولود جديدفهي نسبة تعتبر يعني
+
+113
+00:11:06,220 --> 00:11:11,100
+عالية، المفروض الواحد يفكر فيها ويدور عليها وكذا،
+
+114
+00:11:11,100 --> 00:11:16,140
+اللي راح ناخد بعد شوية ليش أو كيف احنا بندور، وشو
+
+115
+00:11:16,140 --> 00:11:21,840
+بنستخدمه كمحددات لأهمية هذا الجانب، بعدين فيه
+
+116
+00:11:21,840 --> 00:11:27,060
+Sickle Cell Disease، مرض الأنيميا المنجلية، هبوط
+
+117
+00:11:27,060 --> 00:11:32,890
+وظيفة الغد الدراقية،مرض عندي بتعامل معاه كثير الـ
+
+118
+00:11:32,890 --> 00:11:38,090
+Phenylketonuria في أشياء ثانية برضه Severe
+
+119
+00:11:38,090 --> 00:11:43,010
+congenital adrenal hyperplasia أو Severe combined
+
+120
+00:11:43,010 --> 00:11:46,730
+immune deficiency كالكتوسيميا أنا أظن Mabel's
+
+121
+00:11:46,730 --> 00:11:52,590
+syrup disease، Homocystinuria وكذا أنا يعني أظن
+
+122
+00:11:52,590 --> 00:11:58,540
+الآنبالذات الأمراض النادرة وفي بيئة أو في مجموعة
+
+123
+00:11:58,540 --> 00:12:02,360
+بشرية مش عندنا، مش في population تبعتنا، ما
+
+124
+00:12:02,360 --> 00:12:07,120
+بيهمنيش كثير، بس Sickle Cell Disease متواجد،
+
+125
+00:12:07,120 --> 00:12:10,360
+الـHypothyroidism ممكن، الـPhenylketonuria أنا
+
+126
+00:12:10,360 --> 00:12:16,340
+متأكد عندنا، البقية حاطين عندهم كمية قليلة، وطبعاً
+
+127
+00:12:16,340 --> 00:12:21,160
+جزء من الموضوع يتبع فهم الواحد لنوع الـInheritance
+
+128
+00:12:21,160 --> 00:12:22,300
+تبع هذا الـDisease
+
+129
+00:12:25,810 --> 00:12:34,610
+هذه الأمراض بتهمنا من ناحية بتهمنا من ناحية إنها
+
+130
+00:12:34,610 --> 00:12:37,770
+أول شيء طبعاً لازم تكون الأشياء اللي موجودة عندنا
+
+131
+00:12:37,770 --> 00:12:41,670
+يعني ما بهمني مرض أنا مش موجود في الـ population
+
+132
+00:12:41,670 --> 00:12:48,290
+تبعتي، هذه من ناحية وهنا نتكلم على Newborn
+
+133
+00:12:48,290 --> 00:12:55,380
+Screening Program برنامج المسح للموليد الجددهذا
+
+134
+00:12:55,380 --> 00:12:58,840
+برنامج اتطرقت إليه من قبل إنه إحنا بنطبقينه في
+
+135
+00:12:58,840 --> 00:13:02,260
+القردن الله يرضى عليها الدكتورة سناسق في الحيط قبل
+
+136
+00:13:02,260 --> 00:13:09,160
+مدة يعني كافحت في وزارة الصحة حتى تخلي البرنامج
+
+137
+00:13:09,160 --> 00:13:15,720
+هذا موجود وشو الجوانب اللي يعني بندور عليها وكيف
+
+138
+00:13:15,720 --> 00:13:24,710
+بندور عليها فهي بشكل أساسيزي في غزة وفلسطين إنه كل
+
+139
+00:13:24,710 --> 00:13:29,350
+مولود على الأسبوع الأول على عمر الأسبوع على
+
+140
+00:13:29,350 --> 00:13:33,950
+الولادة الطبيعية لما يروح البيت بيأتي بعد أسبوع
+
+141
+00:13:33,950 --> 00:13:38,070
+بيأخذ المطعم الأول هيك تقريبًا يعني لأنه في
+
+142
+00:13:38,070 --> 00:13:46,350
+متابعات محددة للمولود الجديد فمنها بيأخذ نقطة دم
+
+143
+00:13:46,350 --> 00:13:52,030
+من كعب الطفلفهي شغل يعني بيكون جاي يأخذ المطعم
+
+144
+00:13:52,030 --> 00:13:58,230
+أهله جاي بينه وبنأخذ على ورقة نشاف بحطه نقطة دم
+
+145
+00:13:58,230 --> 00:14:05,030
+واحدة وبيبعثوها للمختبر يعني هي بتنشف وتترك وبعدين
+
+146
+00:14:05,030 --> 00:14:10,970
+كل أسبوع كل مدة بيلموا اللي موجود هذا وفيه فحص راح
+
+147
+00:14:10,970 --> 00:14:18,690
+نحكي عنه فحص سريع لأشياء كثيرة وبيعملوا الفحصيعني
+
+148
+00:14:18,690 --> 00:14:26,890
+ليش يعمل أو لأي أمراض يعمل لازم يكون فيها محددات
+
+149
+00:14:26,890 --> 00:14:36,970
+مهمة أولاً اللي هي سمنها يعني القدرة التحليلية أو
+
+150
+00:14:36,970 --> 00:14:42,050
+الفائدة التحليلية لهذا الفحص فالمفروض يكون زي ما
+
+151
+00:14:42,050 --> 00:14:45,670
+كاتبين قدامكم في هذا الـBox مهم كثير لشروط
+
+152
+00:14:45,670 --> 00:14:49,670
+الـScreening Program«محاولة عمل محاولة عمل عمل عمل
+
+153
+00:14:49,670 --> 00:14:50,710
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+154
+00:14:50,710 --> 00:14:53,230
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+155
+00:14:53,230 --> 00:14:53,590
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+156
+00:14:53,590 --> 00:14:53,610
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+157
+00:14:53,610 --> 00:14:54,150
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+158
+00:14:54,150 --> 00:14:56,990
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+159
+00:14:56,990 --> 00:14:57,010
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+160
+00:14:57,010 --> 00:15:03,910
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+161
+00:15:03,910 --> 00:15:11,390
+عمل عمل عمل عمل عمل
+
+162
+00:15:11,390 --> 00:15:16,430
+عمل
+
+163
+00:15:16,430 --> 00:15:23,550
+عفالـ Hypothyroidism الشغل على الـ TSH مثلا أو
+
+164
+00:15:23,550 --> 00:15:30,390
+اللي هو الـ T3 و T4 بس أضل من الـ TSH إذا كان
+
+165
+00:15:30,390 --> 00:15:34,610
+مرتفع معناته فيه Hypothyroidism الفناع الأنالين
+
+166
+00:15:34,610 --> 00:15:38,230
+اللي بيطلع ويكون مرتفع في الفناع الكيتونيوريا
+
+167
+00:15:38,230 --> 00:15:45,430
+بيكون يعني مرتفع في اللي عندهم المتابولات هذا في
+
+168
+00:15:45,430 --> 00:15:51,810
+اللي عندهم هذا المرضفالفكرة أنه لازم يكون عندي فحص
+
+169
+00:15:51,810 --> 00:16:00,010
+simple وسريع يعني ما بده شغل كثير وبعدين إمكانية
+
+170
+00:16:00,010 --> 00:16:05,830
+عمله رخيص مابدنا إشي مكلف الصراحة مثلا، أنا اللي
+
+171
+00:16:05,830 --> 00:16:12,110
+بيجننني مثلا، إن شاء الله فاهمين عليا بيجننني مثلا
+
+172
+00:16:12,110 --> 00:16:16,560
+بلد زي أمريكا مع مرض زي الـ COVIDوحتى في الأردن
+
+173
+00:16:16,560 --> 00:16:21,060
+وكذا، يعني هنا في الأردن الـ يعني بتتكلم على
+
+174
+00:16:21,060 --> 00:16:26,660
+بالمتوسط أو تقريبًا فحص الـ COVID 50، 30 دينار،
+
+175
+00:16:26,660 --> 00:16:31,880
+هيك تقريبًا سعره 30 دينار يعني، ماعرفش كيف تحسبوها
+
+176
+00:16:31,880 --> 00:16:38,380
+يعني بتطلع حوالي على point seven يعني تقريبًا
+
+177
+00:16:38,380 --> 00:16:46,140
+خمسين دولار، خمس واربعين دولار، ماشيفيجي الواحد
+
+178
+00:16:46,140 --> 00:16:50,240
+مثلًا في بلد زي أمريكا يقول في بعض الناس بيدعو إنه
+
+179
+00:16:50,240 --> 00:16:56,040
+نفحص كل البشر أو نفحص عدد كبير طب ما أنت كل إنسان
+
+180
+00:16:56,040 --> 00:17:01,620
+بـ 30، 40 دولار لكل بني آدم، هاي صارنا بالمليارات،
+
+181
+00:17:01,620 --> 00:17:07,420
+إذا ما إلها قيمة وما إلها فايدة وما إلها مية، راح
+
+182
+00:17:07,420 --> 00:17:16,460
+تكون يعني .. يعني ..هدر كامل أو هدر كبير من
+
+183
+00:17:16,460 --> 00:17:24,380
+الإمكانات اللي كان ممكن تتوجه لشيء مفيد الموضوع
+
+184
+00:17:24,380 --> 00:17:28,860
+الثاني يعني الأهمية الثانية للـلإيش نختار ونحط في
+
+185
+00:17:28,860 --> 00:17:35,220
+هذا البرنامج للفحص والمسح الموليد الجدد مسح كامل
+
+186
+00:17:35,220 --> 00:17:40,740
+في المجتمع أن يكون الـ Clinical Validity يعني
+
+187
+00:17:40,740 --> 00:17:45,160
+الفحص الجانب الأول أنه القدرة التحليلية للفحص شو
+
+188
+00:17:45,160 --> 00:17:51,080
+علاقة الفحص بالمرض هل في علاقة شقوية وأن نكون أخيص
+
+189
+00:17:51,080 --> 00:17:54,820
+وأن نكون سريع وأن نكون أقدر يسوي الفحص هذا بشكل
+
+190
+00:17:54,820 --> 00:18:00,580
+كويسالنقطة الثانية، راح نحكي عنها كمان اللي هي الـ
+
+191
+00:18:00,580 --> 00:18:05,420
+Clinical Validity إنه الـ Laboratory Test Highly
+
+192
+00:18:05,420 --> 00:18:10,420
+Sensitive وHighly Reliable وSpecific والـ Positive
+
+193
+00:18:10,420 --> 00:18:13,720
+Predictive Value is High يعني نازم High، راح جوانب
+
+194
+00:18:13,720 --> 00:18:18,600
+نحكي عنها بالتفصيل، مهمة النحو الثالثة، اللي هي
+
+195
+00:18:18,600 --> 00:18:22,420
+الـ Clinical Utility يعني الاستفادة السرينية أنا
+
+196
+00:18:22,420 --> 00:18:27,960
+والله إذا مرض قاتل وماعندي علاج لهأيش أفحص عليه؟
+
+197
+00:18:27,960 --> 00:18:30,920
+بينما كل اللي أنا بحكي عنه الأمراض كأمثلة
+
+198
+00:18:30,920 --> 00:18:39,500
+الـHypothyroidism بيعمل تخلف عقلي، بيعمل تقزم،
+
+199
+00:18:39,500 --> 00:18:46,200
+بيأخر نمو الطفل، بيعمله مشاكل كبيرة جدا بحبة بسيطة
+
+200
+00:18:46,200 --> 00:18:50,540
+يومياً يتم علاجها وانتهانا وتكون بعيش الإنسان
+
+201
+00:18:50,540 --> 00:18:57,540
+طبيعيفكون إن واحد مثلها في مصير بينقوسين أسود أو
+
+202
+00:18:57,540 --> 00:19:03,280
+مصير سيء بشيء بسيط هذا مشجع على إن الواحد يعمل هذا
+
+203
+00:19:03,280 --> 00:19:07,060
+الفحص فلازم يكون الـ Treatment available Early
+
+204
+00:19:07,060 --> 00:19:10,120
+institution of treatment before symptoms become
+
+205
+00:19:10,120 --> 00:19:13,280
+manifest, reduce or prevail severe illness يعني
+
+206
+00:19:13,280 --> 00:19:17,020
+هذه ناحية ثانية إن الـ Treatment أحيانًا إذا أنا
+
+207
+00:19:18,030 --> 00:19:22,490
+يعني اتطبقتها في الفترة المبكرة قبل حتى ما المريض
+
+208
+00:19:22,490 --> 00:19:28,150
+يشكي يعني إحنا الـ Hypothyroidism هذا على عمر
+
+209
+00:19:28,150 --> 00:19:32,690
+السنتين إذا لم يتم علاجه الطفل هذا متخلف عقليا مدى
+
+210
+00:19:32,690 --> 00:19:38,510
+الحياة يعني كارثة بينما ممكن يكون طبيعي بعلاج بسيط
+
+211
+00:19:38,510 --> 00:19:42,460
+سهل مافيش فيه إشي يعنيالـ «التجارب العادية
+
+212
+00:19:42,460 --> 00:19:46,500
+والتجارب الفيزيوكالية» «لن تظهر المشكلة في الطفولة
+
+213
+00:19:46,500 --> 00:19:51,280
+الجديدة، يتطلب تجارب» أيه كمان يعني حكيناها أنه
+
+214
+00:19:51,280 --> 00:19:57,000
+الفناع الأناني مثلا عند الولادة والـ TSH عند
+
+215
+00:19:57,000 --> 00:20:01,620
+الولادة نفسها قد لا يكون مرتفعة لأن الطفل باخد من
+
+216
+00:20:01,620 --> 00:20:06,060
+أمه أو بخلص من الفناع الأناني عن طريق أمه،
+
+217
+00:20:06,060 --> 00:20:11,710
+فبالتاليما عنده حتى يعني بيكون بيبين من أولها من
+
+218
+00:20:11,710 --> 00:20:16,990
+أول الولادة بعد أسبوع بيكون ممكن يكون أفضل والـ
+
+219
+00:20:16,990 --> 00:20:21,710
+Screening Program نعمل بهذا الوقتالتجارب مستمرة
+
+220
+00:20:21,710 --> 00:20:24,310
+وخاصة كافية لتجارب التجارب بسبب تجارب التجارب بسبب
+
+221
+00:20:24,310 --> 00:20:28,070
+تجارب التجارب بسبب تجارب التجارب بسبب تجارب تجارب
+
+222
+00:20:28,070 --> 00:20:30,610
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+223
+00:20:30,610 --> 00:20:30,650
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+224
+00:20:30,650 --> 00:20:32,390
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+225
+00:20:32,390 --> 00:20:49,670
+تجارب تجارب تجارب تجارب تجارب تجارب تجار
+
+226
+00:20:50,100 --> 00:20:53,640
+يكون عالي إن أعمل الفحص وراح نشوف أمثل على أهمية
+
+227
+00:20:53,640 --> 00:20:58,060
+هذا الجانب والـ Public Health Infrastructure is in
+
+228
+00:20:58,060 --> 00:21:01,400
+place to inform the newborns, parents and
+
+229
+00:21:01,400 --> 00:21:04,160
+physicians of the results of the screening test to
+
+230
+00:21:04,160 --> 00:21:06,920
+confirm the test result and institute effective
+
+231
+00:21:06,920 --> 00:21:11,940
+treatment and counseling لما نيجي في مجتمع نحط هذا
+
+232
+00:21:11,940 --> 00:21:19,460
+البرنامج للمسح للموليد الجدد يجبإن يكون البلد
+
+233
+00:21:19,460 --> 00:21:25,740
+مستقر يجب أن يكون هناك آليات لتخضيع الراجعة شو
+
+234
+00:21:25,740 --> 00:21:31,280
+بفيدني إن أنا والله أعمل دراسة واطلع مثلا 1% عندهم
+
+235
+00:21:31,280 --> 00:21:38,080
+المرض الـ 1% هدولة المفروض إن أنا أروح أكون قادر
+
+236
+00:21:38,080 --> 00:21:42,640
+على الوصول إليهم مرة ثانية بدي بلكن فحص أشياء أقوى
+
+237
+00:21:42,640 --> 00:21:48,310
+للتأكد بدي أنا أفهمهم شو المرض هذاكيف يتعاملوا
+
+238
+00:21:48,310 --> 00:21:51,790
+معاه، كيف يعلجوا، أبلغ الأطباء اللي بيعلجوا
+
+239
+00:21:51,790 --> 00:21:55,810
+الأطفال دولة وبتابعوهم، شو اللي لازم يعمل وكيف
+
+240
+00:21:55,810 --> 00:21:59,850
+لازم يعمل، شو المتباعت بعد ذلك، شو نتيجة أن هذا
+
+241
+00:21:59,850 --> 00:22:04,430
+الفحص إيجابي، على عكس لو كان الحال سلبي، فبالتالي
+
+242
+00:22:04,430 --> 00:22:09,750
+مابدناش أشي في الحالة يعني، فالنقطة الثلاثة هذولة
+
+243
+00:22:09,750 --> 00:22:19,240
+يعنيإن ما سأقوم فيه خلال برنامج المسح الماليد
+
+244
+00:22:19,240 --> 00:22:26,310
+الجددالوطني للبلد بأكملها لكل الناس لازم يكون له
+
+245
+00:22:26,310 --> 00:22:33,930
+قدرة أو فائدة تحليلية وسريرية واستفادة سريرية منه
+
+246
+00:22:33,930 --> 00:22:41,830
+ممكنة غير هيك ما في داعي أن أحط الفحص ضمن معطيات
+
+247
+00:22:41,830 --> 00:22:49,790
+البرنامج الوطني للمساعدة الجدول
+
+248
+00:22:49,790 --> 00:22:58,260
+هذايعني هو جزءي لناحية محددة في الـ… خلّينا نرجع
+
+249
+00:22:58,260 --> 00:23:10,860
+له شوية، لأ مش هذا ثواني، لأ أنا المفروض، هذه
+
+250
+00:23:10,860 --> 00:23:16,560
+النقطة اللي كنت بحكيها الـ… الـCongelital Hearing
+
+251
+00:23:16,560 --> 00:23:22,450
+Loss لما نسوي Screeningيعني لما يجي الطفل على
+
+252
+00:23:22,450 --> 00:23:26,050
+الإيادة
+
+253
+00:23:26,050 --> 00:23:35,070
+لازم أفحص السماعة تبعه وتأكد إنه بيسمع كويسإنه
+
+254
+00:23:35,070 --> 00:23:40,030
+الإنسان لو فقد سمعه يعني اللي هو يعني إنه صار
+
+255
+00:23:40,030 --> 00:23:47,370
+مشكلة في الأذن مثلا بعد البلوغ أو بعد سنتين وثلاثة
+
+256
+00:23:47,370 --> 00:23:52,670
+بحيث إنه تتكون عنده اللغة يصبح الاستعادة السمع
+
+257
+00:23:52,670 --> 00:23:59,110
+والاتعامل معاه ممتاز لأنه على الأقلالنظم العقلي
+
+258
+00:23:59,110 --> 00:24:04,550
+العصبي للتعامل مع السماء بتظل سليمة وبيكون الإنسان
+
+259
+00:24:04,550 --> 00:24:10,310
+بيقدر يعني دماغه مستطيع التعامل مع اللغة والسمع
+
+260
+00:24:10,310 --> 00:24:16,020
+والكلام بيقدر يتكلمالآن الـ Sensory Neuronal
+
+261
+00:24:16,020 --> 00:24:24,440
+Hearing Loss إذا كان في الطفولة قبل ما مثلاً يعني
+
+262
+00:24:24,440 --> 00:24:31,480
+قبل السنة و سنتين و ثلاثة بقدر أركب لهم الآن قوقعة
+
+263
+00:24:31,480 --> 00:24:39,560
+القوقعة يعني زي سماعة خارجية موصولة بأسلاك داخل
+
+264
+00:24:39,560 --> 00:24:46,170
+الأذن الداخلية على القوقعةفبالتالي، يعني ممكن
+
+265
+00:24:46,170 --> 00:24:52,050
+تعويضها ممكن بدل ما الإنسان أطرم، أبكه، أصم، لا
+
+266
+00:24:52,050 --> 00:24:57,250
+يسمع، لا يتكلم، لا يستطيع ان يتعامل مع الناس،
+
+267
+00:24:57,250 --> 00:25:02,490
+بخليه إنسان طبيعي، حتى لو الإنسان يعني فقد السمع
+
+268
+00:25:02,490 --> 00:25:07,670
+بعدين، ممكن من حركة الشفائف يتعلق، يكون يقدر يفهم
+
+269
+00:25:07,670 --> 00:25:11,710
+شو اللي أمامه بيحكي، شو اللي أشياء، يعني ناحية
+
+270
+00:25:11,710 --> 00:25:19,180
+مهمة جدافإذا اكتشفنا إنه في طفل عنده سمع مشكلة في
+
+271
+00:25:19,180 --> 00:25:24,620
+السمع مبكر فرق السمع على الأرض كيف علاجه ويكون
+
+272
+00:25:24,620 --> 00:25:29,180
+يعني يستطيع يتكلم ويفهم غيره ويفهم على غيره وكذا
+
+273
+00:25:29,180 --> 00:25:35,600
+فهذه مشكلة يعني كبيرة بقية الأمراض والحالات برضه
+
+274
+00:25:35,600 --> 00:25:42,870
+في عليها إشكالات الـكل اللي بيحكوا عنه في هذا
+
+275
+00:25:42,870 --> 00:25:50,810
+الفحص، في هذه الـ Lista اللي هي، نشوف الكلمة اللي
+
+276
+00:25:50,810 --> 00:25:55,050
+فوق اللي هي «Tandem Mass Spectrometry» راح أنا بقى
+
+277
+00:25:55,050 --> 00:26:01,750
+هيتعلمتها جديد مع المحاضرة تبعتكمعشان أن هذا هو
+
+278
+00:26:01,750 --> 00:26:06,230
+نوعية الفحص اللي يستخدم بالفحص اللي حكيت عنه في
+
+279
+00:26:06,230 --> 00:26:10,730
+قضية نقطة الدم على ورقة النشاف اللي إحنا بندور
+
+280
+00:26:10,730 --> 00:26:19,910
+عليها، بنجمعها فهناك، يعني هنا تقريبًا بقدر بجز،
+
+281
+00:26:19,910 --> 00:26:26,970
+يعني يعني أمامي بقدر يمكن خمسين مرض، أربعين مرض
+
+282
+00:26:27,750 --> 00:26:33,030
+اللي حاطين يمكن تشخيصهم عن طريق اللي لو حاطينه لقم
+
+283
+00:26:33,030 --> 00:26:37,210
+واحد الـ BQ يعني أنا كل التعامل مع هذا الجانب من
+
+284
+00:26:37,210 --> 00:26:41,630
+خلال الـ BQ اللي عندي خبرة فيه البقية، قداش والله
+
+285
+00:26:41,630 --> 00:26:48,710
+شائعة في مجتمعاتنا وكم حالة منها يعني في القردن،
+
+286
+00:26:48,710 --> 00:26:54,270
+هذول البقية إحنا بنقول عنهم الأمراض الاستقلابية أو
+
+287
+00:26:54,270 --> 00:27:00,490
+الـ Metabolic Disordersولمّا فيه عندنا مراكز وطنية
+
+288
+00:27:00,490 --> 00:27:04,630
+للوراثة ومركز وطني للسكر والوراثة والأمراض
+
+289
+00:27:04,630 --> 00:27:08,690
+الوراثية فيه إيش في الخدمات وفيه إيش في الجامعة
+
+290
+00:27:08,690 --> 00:27:14,810
+الأردنية بنقدر إن الأردن فيها حوالي بي كيو
+
+291
+00:27:14,810 --> 00:27:19,550
+أربعمائة حالة عندنا موجودين ومتعامل معهم ويلهم
+
+292
+00:27:19,550 --> 00:27:24,580
+طريقة علاج معينة وكذا وكذاأو بقدروا في كل الأردن
+
+293
+00:27:24,580 --> 00:27:29,640
+حوالي 800 حالة 400 لـ 800 مكتشفين وغير مكتشفين
+
+294
+00:27:29,640 --> 00:27:35,820
+ومنها الـ Reds بينما لكل الأمراض التانية فيها
+
+295
+00:27:35,820 --> 00:27:41,720
+بحدود above 300 حالة فالبقية غير الـ PQ يعني
+
+296
+00:27:41,720 --> 00:27:49,420
+نسبتها أقل وإن كان وإن كان يمكن في عائلات معينة
+
+297
+00:27:49,420 --> 00:27:54,990
+نلاقي مشاكل محددةوبسبب زواج الأقارب وهذا الموضوع
+
+298
+00:27:54,990 --> 00:28:00,850
+هناك أمراض كثيرة على الأقل هنا قاعدة جزئية بحوالي
+
+299
+00:28:00,850 --> 00:28:05,770
+خمسين مرض متابوليت الـ Disorder الفكرة هنا شتنتين
+
+300
+00:28:05,770 --> 00:28:13,910
+أنه نوعية الفحص اللي بستخدمه لإكتشاف
+
+301
+00:28:13,910 --> 00:28:17,930
+هذه مجموعة من الأمراض هو الـ 10D Mass Spectrometry
+
+302
+00:28:17,930 --> 00:28:25,150
+هذا اسم الفحصوهو على ورقة النشاف تانديم يعني إشي
+
+303
+00:28:25,150 --> 00:28:29,670
+ورا الثاني وmass spectrometry اللي هو على الكتلة
+
+304
+00:28:29,670 --> 00:28:34,450
+شغل في الكتل يعني أنا ما بفهم تفاصيل الفنية كيف
+
+305
+00:28:34,450 --> 00:28:39,730
+هذا الفحص يعمل بس لعدد كبير من الـmetabolites
+
+306
+00:28:39,730 --> 00:28:49,230
+بتكون وبكون سهل جداًوسريع وبدنا بعدين ندخل في يعني
+
+307
+00:28:49,230 --> 00:28:56,950
+ندخل في كيفية متابعة الحالة الإيجابية وكيف نسوي
+
+308
+00:28:56,950 --> 00:29:00,870
+لهم counseling شو لازم أعمل؟ شو لحل؟ شو الأدوية
+
+309
+00:29:00,870 --> 00:29:04,450
+تبعتها؟ شو بعدين ممكن يعمل؟ شو المستقبل لهذه
+
+310
+00:29:04,450 --> 00:29:09,270
+الحالة؟ فالنقطة الأولى إنه اسمه «Tandem Mass
+
+311
+00:29:09,270 --> 00:29:14,470
+Spectrometry» النقطة الثانيةاللي هي إن هناك ثلاث
+
+312
+00:29:14,470 --> 00:29:18,210
+أنواع من الـ Metabolic Disorders فيه Amino Acid
+
+313
+00:29:18,210 --> 00:29:22,770
+Disorder فيه Organic Acid Disorder فيه Fatty Acid
+
+314
+00:29:22,770 --> 00:29:27,690
+Oxidation Disorder يعني،
+
+315
+00:29:27,690 --> 00:29:34,950
+ماعرفش، أنا نفسي مش حافظ إن هاي تاب على كده وهاي
+
+316
+00:29:34,950 --> 00:29:38,750
+تاب على كده وهاي تاب على كده اللي بعرفه الـ Bq
+
+317
+00:29:38,750 --> 00:29:45,990
+Amino Acidيعني هي النقطة القوية والأساسية يعني
+
+318
+00:29:45,990 --> 00:29:50,730
+هيستسلون نحتاج نطلع عليهم ولا ما نطلعش عليهم ولا
+
+319
+00:29:50,730 --> 00:29:56,890
+إذا الواحد بيشوف يعني أنا على الأقل يعني النقطة
+
+320
+00:29:56,890 --> 00:30:00,900
+اللي بدي إياهااللي هي إنه فيه Amino Acid
+
+321
+00:30:00,900 --> 00:30:04,760
+Disorders، فيه Organic Acid Disorders، والواحد دي
+
+322
+00:30:04,760 --> 00:30:08,560
+كيقرا الأسامي، وفيه Fatty Acid Oxidation
+
+323
+00:30:08,560 --> 00:30:13,400
+Disorders، هدول الثلاثة، يعني يمكن يمكن يجيكم في
+
+324
+00:30:13,400 --> 00:30:17,670
+الامتحان مثلا إنهالشيء الوحيد اللي يمكن ان يتم
+
+325
+00:30:17,670 --> 00:30:20,610
+اكتشافه هو الـ Tandem Mass Spectrometry الوحيد
+
+326
+00:30:20,610 --> 00:30:22,510
+اللي يمكن ان تم اكتشافه هو الـ Tandem Mass
+
+327
+00:30:22,510 --> 00:30:23,630
+Spectrometry الوحيد اللي يمكن ان تم اكتشافه هو الـ
+
+328
+00:30:23,630 --> 00:30:28,470
+Tandem Mass Spectrometry الوحيد
+
+329
+00:30:28,470 --> 00:30:29,850
+اللي يمكن ان تم اكتشافه هو الـ Tandem Mass
+
+330
+00:30:29,850 --> 00:30:30,530
+Spectrometry الوحيد اللي يمكن ان تم اكتشافه هو الـ
+
+331
+00:30:30,530 --> 00:30:33,630
+Tandem Mass Spectrometry الوحيد اللي يمكن ان تم
+
+332
+00:30:33,630 --> 00:30:37,130
+اكتشافه هو الـ
+
+333
+00:30:37,130 --> 00:30:37,410
+Tandem Mass Spectrometry الوحيد اللي يمكن ان تم
+
+334
+00:30:37,410 --> 00:30:39,450
+اكتشافه هو الـ Tandem Mass Spectrometry الوحيد
+
+335
+00:30:39,450 --> 00:30:41,190
+اللي يمكن ان تم اكتشافه هو الـ Tandem Mass
+
+336
+00:30:41,190 --> 00:30:47,370
+Spectrometry الوحيد اللي يمكن ان تم ايعني مش
+
+337
+00:30:47,370 --> 00:30:52,950
+موجودة بس أنا بتوقع نقطتين مهمات اللي هم الـ 10D
+
+338
+00:30:52,950 --> 00:30:59,030
+Mass Spectrometry وبكون هذا فحص بيقولك أشياء كثيرة
+
+339
+00:30:59,030 --> 00:31:07,890
+وهذا فحص simple ويعتمد على نقطة دم جاذبة من كعب
+
+340
+00:31:07,890 --> 00:31:13,730
+الطفل تفحص فيها على أشياء كتيرمثل هذا النوع من
+
+341
+00:31:13,730 --> 00:31:19,570
+الفحص، الورقة هذه أنا بعرف إنه في دول ومجتمعات
+
+342
+00:31:19,570 --> 00:31:24,670
+بتسوي إلى اللي هو نرجع هنا لـ Severe Combined
+
+343
+00:31:24,670 --> 00:31:27,470
+Immune Deficiency Severe Combined Immune
+
+344
+00:31:27,470 --> 00:31:34,390
+Deficiency على الأقل في حوالي 160 إلى ما كانش
+
+345
+00:31:34,390 --> 00:31:39,320
+وصلوا لـ 200 الآن Different Genetic Mutationsففيها
+
+346
+00:31:39,320 --> 00:31:42,980
+طريقة إنه برضه يفحصوا على الـ Severe Combined
+
+347
+00:31:42,980 --> 00:31:49,100
+Immune Deficiency البقية لها فحصات أخرى، الأخر
+
+348
+00:31:49,100 --> 00:31:54,140
+أربع تحت شكلهم من تبعات الـ Metabolic Disorders
+
+349
+00:31:54,140 --> 00:32:02,160
+التانية اللي بتدخل هنا فالنقطة
+
+350
+00:32:02,160 --> 00:32:07,380
+يعني الآن يعنيإذا بنتكلم على مبدأ الـ Personalized
+
+351
+00:32:07,380 --> 00:32:11,200
+Medicine فالنقطة الأولى كانت إنه إذا بعرف الـ
+
+352
+00:32:11,200 --> 00:32:17,340
+History في شيء له جانب وراثي كويس وقوي المفروض
+
+353
+00:32:17,340 --> 00:32:20,640
+أستفيد منه في التعامل مع المرضى زي الـ Colon
+
+354
+00:32:20,640 --> 00:32:26,620
+Cancer الموضوع الثاني إنه أنا لازم كمجتمع كنظام
+
+355
+00:32:26,620 --> 00:32:35,170
+صحي أسوي اللي هم الـ Screening Programاللي هو
+
+356
+00:32:35,170 --> 00:32:43,550
+برنامج مسح الوطني للأمراض
+
+357
+00:32:43,550 --> 00:32:50,730
+الوراثية أو الممكنة عند الأطفال حدثي الولادة النوع
+
+358
+00:32:50,730 --> 00:32:55,550
+الثالث في الـ Personalized Medicine هي قضية الـ
+
+359
+00:32:55,550 --> 00:33:04,520
+Pharmacogenetics يعني علم الأدوية الوراثيوتداخل
+
+360
+00:33:04,520 --> 00:33:09,980
+الوراثة مع الدواء وتأثير الدواء على الإنسان فمن
+
+361
+00:33:09,980 --> 00:33:15,620
+أهم الجوانب، يعني يمكن سمعتها من قبل تقريبًا كثير
+
+362
+00:33:15,620 --> 00:33:20,720
+من الأدوية يتم يعني في جزء أقل يتم التخلص منه عن
+
+363
+00:33:20,720 --> 00:33:26,220
+طريق الـ Ball مباشرة للدواء نفسه بيكون عن طريق الـ
+
+364
+00:33:26,220 --> 00:33:30,520
+Ball من طريق الكلاب بس في كثير من الأدوية بتتم
+
+365
+00:33:30,520 --> 00:33:36,120
+التعامل معها عن طريقالـ CABID والـ Metabolism
+
+366
+00:33:36,120 --> 00:33:42,700
+عمليات أيضًا بتغير طبيعة الدواء وبالتالي بتعمل من
+
+367
+00:33:42,700 --> 00:33:50,500
+هذا الدواء شيء بيكون يعني بعد ما كان مستحيل التخلص
+
+368
+00:33:50,500 --> 00:33:55,580
+منه بشكل سريع بيصير من خلال الـ Ball يتم التخلص
+
+369
+00:33:55,580 --> 00:34:00,740
+منه في أسئلة إن شاء الله أنه كلامي واضح وشرح
+
+370
+00:34:00,740 --> 00:34:07,460
+مفهومهما فيش مشاكل إذا كريم بده يسأل بالذات أنا
+
+371
+00:34:07,460 --> 00:34:15,340
+حاضر إذا عنده سؤال كريم ماشي
+
+372
+00:34:15,340 --> 00:34:20,280
+فالنقطة
+
+373
+00:34:20,280 --> 00:34:27,800
+اللي بدنا نذكرها إنه تعامل الأدوية بسبب الوراثة
+
+374
+00:34:27,800 --> 00:34:34,720
+وتعامل الجسم مع الأدوية بسبب الوراثة جانب مهمويعني
+
+375
+00:34:34,720 --> 00:34:41,040
+هناك كثير من الأدوية اللي بيكون فيها دوانة معينة
+
+376
+00:34:41,040 --> 00:34:46,700
+في تعامل الجسم معها أحيانًا يتم التعرف على، نحن
+
+377
+00:34:46,700 --> 00:34:55,700
+بنقسم الناس لثلاث أقسام اللي هم يعني، يعني حاطينهم
+
+378
+00:34:55,700 --> 00:35:01,740
+هنا الـPoor Metabolizer الشخص اللي جسمه بيقدرش
+
+379
+00:35:01,740 --> 00:35:08,330
+يتعاملمع الدواء بشكل سريع وفيه الـNormal
+
+380
+00:35:08,330 --> 00:35:12,330
+Metabolizer والـUltra-fast Metabolizer الـUltra
+
+381
+00:35:12,330 --> 00:35:18,470
+-fast هو اللي بيكون يعني جسمه بتعامل مع الدواء
+
+382
+00:35:18,470 --> 00:35:24,370
+بشكل سريع جداً فالكلام طبعاً، ليش الـLiver
+
+383
+00:35:24,370 --> 00:35:29,050
+Metabolism؟ هو الـLiver مصنع الكيموي تبع الجسم
+
+384
+00:35:29,050 --> 00:35:34,360
+آلافالعمليات الكيميائية بتتم في الكبد سبحان الله
+
+385
+00:35:34,360 --> 00:35:39,040
+كيف خلق الله للإنسان وكيف الكبد والكبد يعني ميزته
+
+386
+00:35:39,040 --> 00:35:44,900
+إنه إذا أكلت شيء أو شربت شيء أو دخل شيء في الأمعاء
+
+387
+00:35:44,900 --> 00:35:49,740
+لازم يمر على الكبد قبل ما يدخل لبقية الجسم ففي شيء
+
+388
+00:35:49,740 --> 00:35:53,780
+بيسموه، عرفته عنه اسمه الـ First Pass Metabolism
+
+389
+00:35:53,780 --> 00:36:00,720
+فإحنا بنقسم الناس أحيانًا لبعض الأدويةإنه فيه
+
+390
+00:36:00,720 --> 00:36:04,900
+الإنسان بتعامل مع الدواء هذا بشكل بطيء وما بتقدر
+
+391
+00:36:04,900 --> 00:36:09,440
+يتعامل معاه بشكل المناسب أو السريع فإحنا جزء من
+
+392
+00:36:09,440 --> 00:36:14,320
+بالذات الأدوية اللي لازم تُخر بشكل مزمن ولازم يكون
+
+393
+00:36:14,320 --> 00:36:18,740
+لها مستوى جيد حتى اللي بيسميه في الـ Pharmacology
+
+394
+00:36:18,740 --> 00:36:24,360
+في علم الأدوية الـ Therapeutic Index يعنيالمدى
+
+395
+00:36:24,360 --> 00:36:31,440
+المفيد أو الصحي أو المعالج عكس أنه لما نوصل لمستوى
+
+396
+00:36:31,440 --> 00:36:38,640
+السمي أو اللي هو أعلى من المطلوب فالإنسان لو كان
+
+397
+00:36:38,640 --> 00:36:45,640
+poor-metabolizer إحنا مرات كثيرة بنعمل الدواء حتى
+
+398
+00:36:45,640 --> 00:36:50,700
+نوصل ما يسمى الـSteady State الـSteady State يعني
+
+399
+00:36:50,700 --> 00:36:54,940
+زي اللي بالنص هي المناسبة، هي المطلوبةيكون الدواء
+
+400
+00:36:54,940 --> 00:36:59,260
+كل الوقت ضمن الـ Range المطلوب طبعاً لما أنا أخد
+
+401
+00:36:59,260 --> 00:37:04,060
+أي حب الدواء أو حد يعطينا إبرد دواء راح فجأة
+
+402
+00:37:04,060 --> 00:37:08,880
+أتلافي مستوى الدواء يعلى كثير ومع ذلك يرجع وينزل،
+
+403
+00:37:08,880 --> 00:37:14,060
+ماشي؟ فالفكرة لماذا بعض الأدوية بنعطيها مثلاً إذا
+
+404
+00:37:14,060 --> 00:37:19,180
+بتنتبه مرة باليوم، مرتين باليوم، أربع مرات باليوم،
+
+405
+00:37:19,180 --> 00:37:22,420
+في أدوية خمس مرات باليوم، لماذا بنعطيها بهذه
+
+406
+00:37:22,420 --> 00:37:26,710
+التفصيل؟لماذا يقول الشركة والمصنّي على الدواء
+
+407
+00:37:26,710 --> 00:37:29,130
+بتقولّك لما تدرس الـ Pharmacodynamics
+
+408
+00:37:29,130 --> 00:37:34,630
+وPharmacokinetics تبع الدواء، ماشي، بتقولّه إن
+
+409
+00:37:34,630 --> 00:37:39,010
+مثلا هذا لازم يستخدم بهذا المدّي يعني كل مرتين،
+
+410
+00:37:39,010 --> 00:37:42,910
+ثلاث، أربع باليوم، مرة باليوم ممكنة ولا لأ؟
+
+411
+00:37:42,910 --> 00:37:47,330
+فالـEndonormal
+
+412
+00:37:47,330 --> 00:37:51,590
+Metabolism ومنعطيه الـDose بالشكل المتوقع الطبيعي
+
+413
+00:37:51,960 --> 00:37:56,620
+الأصل إنه يظل مستوى الدواء ضمن الـ Range المطلوب
+
+414
+00:37:56,620 --> 00:38:02,020
+وهذا الإنسان الحالي المطلوب بينما إذا كان إنسان
+
+415
+00:38:02,020 --> 00:38:06,040
+poor متابوليزر اللي راح يصير إذا طبقت نفس النظام
+
+416
+00:38:06,040 --> 00:38:09,740
+عليه راح يكون نتيجة الأمر هذا إنه يصبح هناك
+
+417
+00:38:09,740 --> 00:38:14,520
+accumulation تجمع للدواء في الجسم لحيث إنه يصل إنه
+
+418
+00:38:14,520 --> 00:38:20,600
+يكون على مستوى أو حد ثمني يسبب مرض ويسبب مشكلة
+
+419
+00:38:21,290 --> 00:38:24,730
+فبتكون هذا في الـ Pore Metabolizer وضلتني أعطي نفس
+
+420
+00:38:24,730 --> 00:38:29,730
+الطريقة في مقابل إنه لو عندي واحد سريع جدا و أسرع
+
+421
+00:38:29,730 --> 00:38:34,450
+من المعتاد النتيجة إنه مرحلة قفايدة من الدواء لأن
+
+422
+00:38:34,450 --> 00:38:37,930
+أصلا الدواء ما صارش في المستوى الكويس اللي يعطيني
+
+423
+00:38:37,930 --> 00:38:42,350
+النتيجة اللي المطلوبة فبتكون هذا يبدو زيدي الجرعة
+
+424
+00:38:42,760 --> 00:38:48,480
+وبدّو يزيد أو يقلل مدة بين الدواء الجرعة والثانية
+
+425
+00:38:48,480 --> 00:38:59,280
+عشان يعني يوصل إنه يعني يكون يكون بشكل جيد يعني
+
+426
+00:38:59,280 --> 00:39:06,220
+فهذه الأنواع الثلاثة للجسم لما نتكلم عن الأدوية
+
+427
+00:39:06,220 --> 00:39:15,410
+والإنسان كيف التعامل معاهالملاحظ أن أهم مجموعة
+
+428
+00:39:15,410 --> 00:39:25,670
+إنزيمات بتتم بتسوي هذا الموضوع اللي هو الـ
+
+429
+00:39:25,670 --> 00:39:33,790
+«Cytochrome-B» «Cytochrome-B» هو إنزيم دخل في قضية
+
+430
+00:39:35,070 --> 00:39:39,210
+يعني الـ Metabolism لكثير من الأدوية وكثير من
+
+431
+00:39:39,210 --> 00:39:43,050
+المُركّبات داخل الجسم هو من أهم الإنزيمات، بس في
+
+432
+00:39:43,050 --> 00:39:49,010
+غيره، وفي أشياء ثانية فهذا
+
+433
+00:39:49,010 --> 00:39:57,790
+لائحة أو جدول لما هو معلوم أو يُنصح به في حالات
+
+434
+00:39:57,790 --> 00:40:04,870
+إعطاء أدوية معينة إنه يتم الانتباه لناحية معينة
+
+435
+00:40:05,390 --> 00:40:09,870
+لأنها بتفرق كثير بين Slow Metabolizer و Ultra-Fast
+
+436
+00:40:09,870 --> 00:40:14,310
+Metabolizer وهدولة فيه نسب كبيرة منهم لحيث إنه
+
+437
+00:40:14,310 --> 00:40:20,110
+مرات بيخربطك وبيخلي الدواء يكون فيه مشكلة الجدول
+
+438
+00:40:20,110 --> 00:40:27,710
+هذا أنا بس بدي أركز على ناحية تانية الناحية الأولى
+
+439
+00:40:29,340 --> 00:40:36,800
+هذه الأشياء اللي متفق عليها أو في دليل علمي تجاربي
+
+440
+00:40:36,800 --> 00:40:46,400
+قوي على كيفية تعامل الجسم مع هذه الأدوية المثال
+
+441
+00:40:46,400 --> 00:40:52,240
+الأول يعني اللي هو معروف ومشهور التفول الـ G6PD
+
+442
+00:40:52,240 --> 00:41:01,940
+«كل جدول بديشية»ممكن تقرأوا عن الـ HLA-B5701 على
+
+443
+00:41:01,940 --> 00:41:07,020
+الأبا كافير حاطينه بـ Case 1 كمثال، هي
+
+444
+00:41:07,020 --> 00:41:10,600
+Individualized Medicine يعني أنت لما بتشوف بني آدم
+
+445
+00:41:10,600 --> 00:41:13,540
+عنده شغل معين بتقدر تعطيه أو بتقدرش تعطيه هذا
+
+446
+00:41:13,540 --> 00:41:20,130
+الأشياء فالأدوية زي الـ Chloroquineدول ملاريا الـ
+
+447
+00:41:20,130 --> 00:41:25,370
+Prima Queen برضه يستخدم في الملاريا الـ Dapsin
+
+448
+00:41:25,370 --> 00:41:31,030
+برضه يستخدم في أمراض كثيرة كجزء وأدوية ثانية
+
+449
+00:41:31,030 --> 00:41:34,930
+الممنوع
+
+450
+00:41:34,930 --> 00:41:38,870
+يأخذها الـ G6PD الكلوراكوين أو الـ
+
+451
+00:41:38,870 --> 00:41:42,370
+Hydroxychloroquine مع أدوية ثانية اللي عندهم تفوّل
+
+452
+00:41:42,370 --> 00:41:46,300
+اللي هو الـ G6PD deficiencyالذي عنده نقص هذا
+
+453
+00:41:46,300 --> 00:41:49,460
+الانزيم أو ميوتاشيا في هذا الانزيم أو Extinct
+
+454
+00:41:49,460 --> 00:41:53,300
+Recidivism بيصير عنده تفول اللي منقوله بيصير
+
+455
+00:41:53,300 --> 00:41:57,560
+Hemolysis وبذات الـ Chloroquine فالأصل إذا أنا بدي
+
+456
+00:41:57,560 --> 00:42:02,040
+أعطي إنسان Chloroquine أو كده أسأله أفحصه على الـ
+
+457
+00:42:02,040 --> 00:42:07,020
+G6PD فهذا مثال على Individualized Medicine بالنسبة
+
+458
+00:42:07,020 --> 00:42:14,290
+للـ Pharmacogenetics على الـ G6PDالـ Cytochrome
+
+459
+00:42:14,290 --> 00:42:19,850
+وفيه إنزيمات ثانية ما بدنا شيها كتير كتير كتير بس
+
+460
+00:42:19,850 --> 00:42:25,870
+الـ G6PD الدوة الثانية اللي بين قوسين بيجنن وبيخل
+
+461
+00:42:25,870 --> 00:42:30,210
+الواحد ماعرفش مرات كيف يتعامل معاه اللي هو الـ
+
+462
+00:42:30,210 --> 00:42:35,010
+Warfarin الـ Warfarin اسمه Comodin أو مرات إله
+
+463
+00:42:35,010 --> 00:42:42,280
+أسماء ثانية عبارة عن مميّع للدمالـ Warfarin هو
+
+464
+00:42:42,280 --> 00:42:50,000
+Vitamin K انهيبتر فالـ Plotting Factors اللي هم
+
+465
+00:42:50,000 --> 00:43:00,000
+1972، عشرة و تسعة و سبعة و اثنين بيكونوا Dependent
+
+466
+00:43:00,000 --> 00:43:04,100
+و كلهم من الـ Liver في الغالبكل الـ Coagulation
+
+467
+00:43:04,100 --> 00:43:10,620
+Factors من اللفر بس الـ Oral Vitamin K Inhibitor
+
+468
+00:43:10,620 --> 00:43:16,600
+اللي هو الـ Warfarin بيمنع هدولة الأربعة بالذات
+
+469
+00:43:16,600 --> 00:43:20,240
+معاهم
+
+470
+00:43:20,240 --> 00:43:26,240
+الـ Protein C و Protein S برضه بتتم تصنيعهم في
+
+471
+00:43:26,240 --> 00:43:33,050
+الكبد بتأثير الـ Warfarinفالـ Warfarin بيجنن يعني
+
+472
+00:43:33,050 --> 00:43:37,370
+لما نيجي نضطر لشخص عنده جلطة خايفين أنه يصير عنده
+
+473
+00:43:37,370 --> 00:43:42,870
+جلطة في الأوردة، جلطة على القلب، جلطة هنا، جلطة
+
+474
+00:43:42,870 --> 00:43:51,450
+هناك، بدي أعطيه مميع، فالـ Warfarin من الأدوية في
+
+475
+00:43:51,450 --> 00:43:57,430
+مرات في ناس بيكونوا حسسين جدا، بعطيهمو1 ميلي جرام
+
+476
+00:43:57,430 --> 00:44:02,270
+بيتلاقي ميعله الدم كتير أو بالعكس، في ناس بعطيهم
+
+477
+00:44:02,270 --> 00:44:05,750
+خمس حبات، خمس ميلي جرام، يعني خمس وعشرين ميلي
+
+478
+00:44:05,750 --> 00:44:10,630
+جرام، بيتلاقي لسه دمه مش ميعل، احنا بنعتمد على الـ
+
+479
+00:44:10,630 --> 00:44:15,190
+BTINR الـ Brothrombin Time International
+
+480
+00:44:15,190 --> 00:44:20,830
+Normalized Ratio هدولة نطلع على في حالة الـ
+
+481
+00:44:20,830 --> 00:44:27,190
+Warfarinوبكون يعني في صعوب بالغ أحيانًا كثيرة أنه
+
+482
+00:44:27,190 --> 00:44:33,030
+نظبط الموضوع غير موضوع الـ Metabolism هذا الـ
+
+483
+00:44:33,030 --> 00:44:36,170
+Warfarin
+
+484
+00:44:36,170 --> 00:44:42,750
+يعني جزء من الأحيان التأثير العكسي لموضوع الـ
+
+485
+00:44:42,750 --> 00:44:47,050
+Cytochrome B450
+
+486
+00:44:47,050 --> 00:44:54,550
+اللي هو أهم واحد واللي له أنواعمفهوم إنه في بعض
+
+487
+00:44:54,550 --> 00:44:58,690
+الأدوية بتنشطه وفي بعض الأدوية بتضعفه وتمنعه
+
+488
+00:44:58,690 --> 00:45:02,430
+فتأثيره على هذا الأمر إنه بيصير عندي Drug Drug
+
+489
+00:45:02,430 --> 00:45:06,530
+Interaction بيصير عندي إنه إذا الدوة اللي فلاني
+
+490
+00:45:06,530 --> 00:45:10,930
+أخده إنسان ما بيصيرش يأخذ الدوة اللي فلاني لأنه
+
+491
+00:45:10,930 --> 00:45:14,650
+بيصير Drug Drug Interaction وبتكون هذه يمكن أوضح
+
+492
+00:45:14,650 --> 00:45:20,810
+في اللي عندهم خواصة جينية معينة فاللي بدي تحفظه
+
+493
+00:45:20,810 --> 00:45:26,060
+عشانالكلام اللي حكيناه، خلّيني نركز على الـ
+
+494
+00:45:26,060 --> 00:45:29,940
+Warfarin بقية الأشياء أدوية كثير مهمة، أدوية
+
+495
+00:45:29,940 --> 00:45:36,780
+بنتعامل معاها كثير أحياناً نوع من المرضى بحتاجوه،
+
+496
+00:45:36,780 --> 00:45:41,300
+وتفاصيلها بديشية الـ Warfarin
+
+497
+00:45:47,210 --> 00:45:50,830
+VKORC1 طبعاً الـ Genes بيكون الـ Capital Letters
+
+498
+00:45:50,830 --> 00:45:54,650
+وكل هنا، احنا بنتكلم على مستوى الـ Gene طبعاً كل
+
+499
+00:45:54,650 --> 00:45:58,270
+Gene المفروض انه يطلق Enzyme بيكون واحد يدور شو هو
+
+500
+00:45:58,270 --> 00:46:08,130
+و اين شغله و كده فالـ VKORC1 و الـ Cytochrome B2C9
+
+501
+00:46:08,130 --> 00:46:14,790
+هذولة يعني احفظوا انه اللي مدخل بالـ Warfarinأتوقع
+
+502
+00:46:14,790 --> 00:46:18,350
+يعني سواء أنا بدي أجيب أسئلة أو يمكن الـUSA مليه
+
+503
+00:46:18,350 --> 00:46:22,350
+يعني الواحد يتطلع الجدول هذا ويحاول يستوعب منه
+
+504
+00:46:22,350 --> 00:46:26,490
+أكتر ما بيقدر كل دوة رفع مبسيطة أعزونية، زيدل،
+
+505
+00:46:26,490 --> 00:46:32,670
+باريزيناميد، هدولة للـTB الـisopropionid-3 مشهور
+
+506
+00:46:32,670 --> 00:46:37,730
+ومعروف والهيدرالازين للضغط كلهم أنواع عدوية في كل
+
+507
+00:46:37,730 --> 00:46:44,360
+واحد لهجين معين مهم إن الواحد يتعلم إنه شو تأثيره
+
+508
+00:46:44,360 --> 00:46:48,080
+وشو تأثير الدواء على هذا الجين وهي الناحي المهمة
+
+509
+00:46:48,080 --> 00:46:57,900
+الـ Cytochrome يعني تقريبًا Cytochrome B450 القليل
+
+510
+00:46:57,900 --> 00:47:01,540
+استبعاته أو أنواعه الـ enzymes اللي بتدخل في الـ
+
+511
+00:47:01,540 --> 00:47:06,590
+Drug Metabolism يعني عددها كبير هي أكبر مجموعةو
+
+512
+00:47:06,590 --> 00:47:10,130
+تقريبًا تسعين بالمية من الأدوية تسعين بالمية من
+
+513
+00:47:10,130 --> 00:47:14,430
+الأدوية بتتم الـ Metabolism تبعها من خلال هذا
+
+514
+00:47:14,430 --> 00:47:20,410
+النضعف فكل ما إنسان عنده قليل معين ممكن يكون Slow
+
+515
+00:47:20,410 --> 00:47:26,850
+أو Fast Acetylator أو Fast Metabolizer وكذا وهذه
+
+516
+00:47:26,850 --> 00:47:31,710
+الأنواع تبعتهم ويعني المبدأ أنا مابديش أساس
+
+517
+00:47:31,710 --> 00:47:38,500
+التفاصيل هذا Cytochrome 3A4أو كروم B3A4 مثلاً، لا
+
+518
+00:47:38,500 --> 00:47:42,740
+أريد أن يكون هذا يمكن أن واحد ينتبه عليها إنه أكثر
+
+519
+00:47:42,740 --> 00:47:47,820
+واحد بـ 34% هذا حسب دراسة معينة في population معين
+
+520
+00:47:47,820 --> 00:47:52,880
+في وقت معين، هكذا لك فأهمية
+
+521
+00:47:52,880 --> 00:47:57,340
+الموضوع هذا أنه
+
+522
+00:47:57,340 --> 00:48:04,200
+نشوف هذا الجدول اللي فوق ماشي
+
+523
+00:48:08,610 --> 00:48:14,890
+إنه الإحتمالات أحيانًا اللي نتكلم عنها هو دراسة
+
+524
+00:48:14,890 --> 00:48:19,170
+فيه إذا الواحد بيرجع إلى المرجع تبعها اللي هو
+
+525
+00:48:19,170 --> 00:48:23,230
+«Cytochrome B450»
+
+526
+00:48:23,230 --> 00:48:32,150
+النوعية تبعته «2D6» هذا النوعية لما نيجي لهذا الـ
+
+527
+00:48:32,150 --> 00:48:38,400
+«إنزايم» بالذاتوأشوف ما هي الـ Alleles ما هي
+
+528
+00:48:38,400 --> 00:48:45,460
+المتغيرات أو أنواع الجين هذا بلاقيهم يا إما الـ
+
+529
+00:48:45,460 --> 00:48:51,780
+Wild-type اللي هو الإعتياد اللي موجود عند الناس أو
+
+530
+00:48:51,780 --> 00:48:57,220
+عند الغالبية وإذا في بعضهم ممكن Completely Absent
+
+531
+00:48:57,220 --> 00:49:04,630
+يعني هذا صفرفي بعضهم موجود بس مش شغل كامل Reduced
+
+532
+00:49:04,630 --> 00:49:09,970
+وفي بعضهم بيكون لأ Fast Metabolizer وIncreased
+
+533
+00:49:09,970 --> 00:49:19,570
+Rate of That Enzyme فالفكرة أن التعقيد الموضوع هذا
+
+534
+00:49:19,570 --> 00:49:27,040
+بالنسبة للجين واحد في محل واحد لما نيجي ناخدإن صار
+
+535
+00:49:27,040 --> 00:49:31,780
+عندى أربع احتمالات، أربع Alleles كل واحد إله يعني
+
+536
+00:49:31,780 --> 00:49:37,900
+خاصية معينة نتذكر إنه كل واحد مننا عنده أربع، Two
+
+537
+00:49:37,900 --> 00:49:43,500
+copies of that gene فالتالي الـ One chromosome لو
+
+538
+00:49:43,500 --> 00:49:48,360
+فرضنا هيك و الـ Other chromosome نفس الترتيب Wild
+
+539
+00:49:48,360 --> 00:49:52,660
+type, reduced, absent or increasedراح ألاقي إن
+
+540
+00:49:52,660 --> 00:49:59,340
+وجود إثنين لسه بعقد الموضوع أكتر بيخليني يعني يكون
+
+541
+00:49:59,340 --> 00:50:05,960
+عندي تفاوت بدرجات مش كبسة كهربا on أو off موجود أو
+
+542
+00:50:05,960 --> 00:50:11,080
+مش موجود فعادة الـ Normal الـ Wild-type إذا موجود
+
+543
+00:50:11,080 --> 00:50:15,080
+two copies هو Normal بس الـ Wild-type واحدة كمان
+
+544
+00:50:15,080 --> 00:50:18,860
+Normal لأنه لو هنا أبسط هو إنه Normal، بنلاقيهم
+
+545
+00:50:18,860 --> 00:50:23,210
+Normal هدولة بنلاقيهم Normalلو واحد increased،
+
+546
+00:50:23,210 --> 00:50:30,350
+ultra-fast فلو كانوا اثنين reduced، راح يكون إذا
+
+547
+00:50:30,350 --> 00:50:35,210
+اثنين reduced، راح يكون النتيجة إنه هذا الإنسان
+
+548
+00:50:35,210 --> 00:50:39,390
+poor metabolizer، الـPhenotype تبعه إذا كان واحد
+
+549
+00:50:39,390 --> 00:50:43,410
+reduced، واحد absent، برضه poor إذا اثنينهم
+
+550
+00:50:43,410 --> 00:50:49,430
+absent، برضه poor الـUltra-fast إذا كان increased،
+
+551
+00:50:49,430 --> 00:50:56,020
+مش عارف يعنيممكن يكون الـUltra-Fast أو مثلًا، لا
+
+552
+00:50:56,020 --> 00:51:00,520
+يتحدث بهذا الشكل ممكن الـLethal combination يكون
+
+553
+00:51:00,520 --> 00:51:05,300
+Ultra-Fast أو الـTwo copies أو كذا أو هنا اللي
+
+554
+00:51:05,300 --> 00:51:09,060
+احنا بنتكلمه ممكن إذا واحدة Reduced وواحدة
+
+555
+00:51:09,060 --> 00:51:12,460
+Increased بيطلع Normal يمكن هذا قصده يكون Normal
+
+556
+00:51:12,460 --> 00:51:16,920
+أو واحدة Absent واحدة Increased برضه إنه بيكون
+
+557
+00:51:16,920 --> 00:51:24,000
+Normalفالموضوع أن الـ «متابوليزم الدراجات» هو نقطة
+
+558
+00:51:24,000 --> 00:51:29,480
+مهمة جدًا وهي اللي يجب أن يبلش فيها عادة اللي هم
+
+559
+00:51:29,480 --> 00:51:33,480
+في المستشفيات الكبيرة اللي بيكون زي الأسماء
+
+560
+00:51:33,480 --> 00:51:37,040
+الأدوية اللي حطيناها في الكيماوي في الأمراض
+
+561
+00:51:37,040 --> 00:51:44,040
+الخطيرة وكذا بتكون عندنا Farm D اللي هم اسمهم
+
+562
+00:51:44,040 --> 00:51:49,600
+دكتور سيدلةوظيفته إنه يشيك على الأدوية والـ
+
+563
+00:51:49,600 --> 00:51:53,040
+Metabolism تبع الأدوية وعلاقة الأدوية مع بعض وكذا
+
+564
+00:51:53,040 --> 00:51:58,860
+النقطة الثانية بالنسبة لهذا الموضوع على الـ
+
+565
+00:51:58,860 --> 00:52:04,460
+Increased Metabolizer أو Ultra-Fast Metabolizer أو
+
+566
+00:52:04,460 --> 00:52:08,500
+Poor Metabolizer أو Normal Metabolizer إن نسبة هذه
+
+567
+00:52:08,500 --> 00:52:14,420
+الأشياء متفاوتة بين البشر مش كل البشر زي بعض
+
+568
+00:52:16,600 --> 00:52:20,500
+فمثلًا، الـPacific Islanders اللي هم في الجزر
+
+569
+00:52:20,500 --> 00:52:27,240
+المحيط الهادي مجتمعات معزولة من سنين ولأجيال كثيرة
+
+570
+00:52:27,240 --> 00:52:33,040
+في تركز للجينات بشكل معين نوعية معينة من
+
+571
+00:52:33,040 --> 00:52:37,400
+الـMutation بتلاقيها صفر والنوعية الثانية من أعلى
+
+572
+00:52:37,400 --> 00:52:41,060
+الناس الأفريقيين
+
+573
+00:52:41,580 --> 00:52:47,760
+أو الأمريكان أو من منطقة الشرق الأوسط أننا مثلا
+
+574
+00:52:47,760 --> 00:52:58,300
+نسب معين للمشاكل هذه أو للملاحظات هذه فالآن
+
+575
+00:52:58,300 --> 00:53:07,700
+يعني احنا اتكلمنا عن بالأول اللي هو موضوع الـ
+
+576
+00:53:09,350 --> 00:53:13,250
+اللي هو إنه لازم واحد ياخد تاريخ مرضي عن الـ Colon
+
+577
+00:53:13,250 --> 00:53:19,730
+Cancer خارج المسح الوطني للموليد الجدد وكيف أتعامل
+
+578
+00:53:19,730 --> 00:53:23,110
+معه والمبدأ الثالث في الـ Personalized Medicine
+
+579
+00:53:23,110 --> 00:53:27,410
+اللي هو موضوع الـ Pharmacogenetics والتعامل مع
+
+580
+00:53:27,410 --> 00:53:32,170
+الأدوية وكيفية تأثير الوراثة بشكل أو بآخر على
+
+581
+00:53:32,170 --> 00:53:38,180
+الأدوية من ناحية الأخيرة، لما نتكلم عن الفحوصاتكيف
+
+582
+00:53:38,180 --> 00:53:42,840
+بدي أتعامل معها؟ وكيف بدي أطبّقها؟ وإذا أنا بحتاج
+
+583
+00:53:42,840 --> 00:53:47,800
+أني أعملها؟ اللي هي الـ Genetic Epidemiology يعني
+
+584
+00:53:47,800 --> 00:53:54,620
+علم الطب المجتمع الوراثي أنا بدور على الأمراض
+
+585
+00:53:54,620 --> 00:54:01,220
+الوراثية وبصير أتكلم عن طبعاً بكون عندي فحص معين
+
+586
+00:54:01,220 --> 00:54:06,640
+لإثبات وجود المرضوبدي أتعامل علاقة الـ «جين» أو
+
+587
+00:54:06,640 --> 00:54:13,580
+علاقة الفحص تبعي بوجود المرض والتعامل معه بنقول
+
+588
+00:54:13,580 --> 00:54:18,300
+النقطة الأولى في هذا الموضوع للمعلمة طب المجتمع
+
+589
+00:54:18,300 --> 00:54:26,140
+إنه أنا ممكن يكون عندي ثلاث أنواع من الدراسات
+
+590
+00:54:26,140 --> 00:54:32,830
+أحيانًا أنا استطيع أن أعملبتسموه Case Control
+
+591
+00:54:32,830 --> 00:54:37,290
+Study أو Cross-Sectional Study أو Cohort يعني
+
+592
+00:54:37,290 --> 00:54:42,090
+دراسة بالحالة والمقارنة أو الحالة والمقارنة مع
+
+593
+00:54:42,090 --> 00:54:48,290
+الطبيعي هذه طريقة معينة ويعني إلها إيجابيات وإلها
+
+594
+00:54:48,290 --> 00:54:53,830
+سلبيات، أسهل الطريقة بجيب مثلًا، بدي أدرس الـ Rabo
+
+595
+00:54:53,830 --> 00:54:57,950
+شو تأثير الجين اللي فلاني على الـ Rabo بروح بجيب
+
+596
+00:54:57,950 --> 00:55:02,440
+لـMeet مريض عنده Raboوبروح أفحص الجين هذا تبعه
+
+597
+00:55:02,440 --> 00:55:09,960
+وبعدين بروح باخد مائة إنسان طبيعي مائة إنسان
+
+598
+00:55:09,960 --> 00:55:14,380
+ماعندوش هذا المرض يعني ممكن يكون عنده أمراض ثانية
+
+599
+00:55:14,380 --> 00:55:20,640
+ويكونون بنفس الدرجة بس الأصل إن أخدهم مائة يعني
+
+600
+00:55:20,640 --> 00:55:26,720
+نفس العدد مشابهين من ناحية العمر من ناحية الجنس
+
+601
+00:55:27,040 --> 00:55:30,240
+يعني إذا أخذت كلهم ذكور لازم الـ «control» كلهم
+
+602
+00:55:30,240 --> 00:55:33,420
+ذكور لا يمكنني أن أخذ المرضى ذكور والـ «control»
+
+603
+00:55:33,420 --> 00:55:37,800
+يكفي مثلًا، ماشي فهذه طريقة أسهل طريقة بيسموها
+
+604
+00:55:37,800 --> 00:55:41,400
+«case control» وهي أضعف طريقة بس يمكن هو اللي
+
+605
+00:55:41,400 --> 00:55:45,380
+موجود عندنا وهو اللي بيقدر أنا أسويه الـ «case
+
+606
+00:55:45,380 --> 00:55:49,440
+control» ممكن أنا أشوف يعني ممكن أدور على الـ
+
+607
+00:55:49,440 --> 00:55:53,340
+genotype ممكن أشوف exposure معين والله radiation
+
+608
+00:55:54,260 --> 00:55:56,980
+اللي اتعرضوا للـ Radiation واللي ما اتعرضوش للـ
+
+609
+00:55:56,980 --> 00:56:01,420
+Radiation بصير أقول Case Control Cross-sectional
+
+610
+00:56:01,420 --> 00:56:08,120
+يعني إن أنا آجي مثلًا على مجتمع وأخذ مسحة منه في
+
+611
+00:56:08,120 --> 00:56:17,140
+لحظة معينة وأخذهم كلهم، ماشي؟ مثلًا آجي أقول أنا
+
+612
+00:56:17,140 --> 00:56:25,420
+والله بدي أدرس مثلًاالمرض الفلاني مثلًا نفترض وجود
+
+613
+00:56:25,420 --> 00:56:29,660
+السكري بين طلبتي الجامعة مثلًا نفترض هيك أو إذا
+
+614
+00:56:29,660 --> 00:56:35,260
+بدي مثلًا مجموعة كبار بالعمر أكبر مثلًا أو أطفال
+
+615
+00:56:35,260 --> 00:56:39,480
+في مدرسة في سن معين أو كذا أو كذا ال population
+
+616
+00:56:39,480 --> 00:56:46,970
+اللي أنا بتكلم عنها باجي باخد كل أفرادهاوبأخدهم
+
+617
+00:56:46,970 --> 00:56:54,600
+مسحة كأن المجتمع بيأكملهبأخد منه قصة واحدة في لحظة
+
+618
+00:56:54,600 --> 00:57:02,440
+معينة بأفحص يعني العينات تبعت الـ يعني هنا بأخد
+
+619
+00:57:02,440 --> 00:57:06,980
+عيناة محددة من المجتمع اللي تم إختارها وتقوم
+
+620
+00:57:06,980 --> 00:57:08,560
+بتقليلها إلى أولئك اللي كان لديه المرض ولم يكن
+
+621
+00:57:08,560 --> 00:57:09,960
+لديه المرض وليس لديه المرض وليس لديه المرض وليس
+
+622
+00:57:09,960 --> 00:57:11,500
+لديه المرض وليس لديه المرض وليس لديه المرض وليس
+
+623
+00:57:11,500 --> 00:57:12,100
+لديه المرض وليس لديه المرض وليس لديه المرض وليس
+
+624
+00:57:12,100 --> 00:57:12,660
+لديه المرض وليس لديه المرض وليس لديه المرض وليس
+
+625
+00:57:12,660 --> 00:57:13,140
+لديه المرض وليس لديه المرض وليس لديه المرض وليس
+
+626
+00:57:13,140 --> 00:57:19,780
+لديه المرض وليس لديه المرض وليس
+
+627
+00:57:19,780 --> 00:57:26,640
+لبس في الغالب إذا بدي عدد يعني ممثل يعني في الأراء
+
+628
+00:57:26,640 --> 00:57:30,600
+السياسية حسب تشوفوا بالانتخابات وغيرها وغيرها إذا
+
+629
+00:57:30,600 --> 00:57:38,140
+فعلا بشكل عشوائي وبشكل ممثل للكل مثلا أخدت مثلا في
+
+630
+00:57:38,140 --> 00:57:44,180
+الانتخابات الرئيسية الأمريكية بس تأخد عينة من ألف
+
+631
+00:57:44,180 --> 00:57:49,940
+شخص لحد ما توصل إنك أخدت عينة من ألف شخصالنتيجة
+
+632
+00:57:49,940 --> 00:57:52,960
+راح تكون قريبة للنتيجة الحقيقية اللي راح تطلع في
+
+633
+00:57:52,960 --> 00:57:59,960
+الانتخابات «±3%» أو الـ Error Margin «2%» أو «4%»
+
+634
+00:57:59,960 --> 00:58:05,520
+على بعض «3%» يعني بالنسبة عالية جداً بكون أنا واثق
+
+635
+00:58:05,520 --> 00:58:10,980
+95% أو 96% أو 97% بكون أنا متأكد أن هذه العلاقة
+
+636
+00:58:10,980 --> 00:58:17,830
+موجودة عن طريقالـ Sample اللي ما تكون ممثلة وكبيرة
+
+637
+00:58:17,830 --> 00:58:21,970
+بما فيه الكفاية ما تكون Sample صغيرة لما نكون في
+
+638
+00:58:21,970 --> 00:58:25,210
+أشياء كثيرة بنتكلم عن حدود الألف في القراءة
+
+639
+00:58:25,210 --> 00:58:29,090
+السياسية مثلا بيقدر الواحد فهو جزء من تصميم
+
+640
+00:58:29,090 --> 00:58:35,270
+الدراسة كم عينة اللي بديها النوع الثالث مرات احنا
+
+641
+00:58:35,270 --> 00:58:40,950
+بنعمل Cohort يعني مثلا اللي هي مجموعة
+
+642
+00:58:43,280 --> 00:58:48,560
+مثلًا أنا آجي أقول في بلد مثلًا نقول غزة أنا بدأ
+
+643
+00:58:48,560 --> 00:58:55,920
+أعمل دراسة بتكون على مدى متابعة لمدة مثلًا سنين
+
+644
+00:58:55,920 --> 00:58:59,660
+كثيرة باخد
+
+645
+00:58:59,660 --> 00:59:04,520
+مثلًا cohort موليد مدينة غزة في اليوم مثلًا في
+
+646
+00:59:04,520 --> 00:59:11,320
+اليوم اللي فلاني موليد مثلًا نقول ألف نفترضفخلاص
+
+647
+00:59:11,320 --> 00:59:17,360
+فدول الألف بسوي نظام أني أنا لما يولدوا بفحصهم
+
+648
+00:59:17,360 --> 00:59:23,220
+بشوفهم يعني في دول مثلا كهر في السواد مثلا وليد
+
+649
+00:59:23,220 --> 00:59:28,720
+سنة الواحد وستينبسنة الـ 1961 فحصوهم وبعد سنة
+
+650
+00:59:28,720 --> 00:59:34,360
+فحصوهم وبعد سنتين فحصوهم نفس فريق الدراسة يتابع
+
+651
+00:59:34,360 --> 00:59:38,020
+هذه المجموعة لحد ما تنتهي الدراسة في مدى الحياة
+
+652
+00:59:38,020 --> 00:59:42,620
+يعني ممكن أنا أشوف والله اللي ولدوا في كذا صار
+
+653
+00:59:42,620 --> 00:59:46,080
+فيهم هيك اللي ولد في كذا صار فيهم هيك اللي كان
+
+654
+00:59:46,080 --> 00:59:50,040
+عندهم كذا صار عندهم هيكفهذه بنسميها Cohort هذا
+
+655
+00:59:50,040 --> 00:59:53,880
+نمضان ثالث من الدراسة على المدى الطويل على المدى
+
+656
+00:59:53,880 --> 00:59:58,600
+البعيد فدولة الاستراتيجيات المعتمدة فدولة اللي
+
+657
+00:59:58,600 --> 01:00:03,100
+ممكن نستخدمهم وبيكون واحد فاهمهم لما نقرأ تقريغ
+
+658
+01:00:03,100 --> 01:00:08,200
+طبي يعني والله الـ Cohort تبعت فحص الأزمة في الـ
+
+659
+01:00:08,200 --> 01:00:12,360
+Inner City في نيويورك مثلا في محل معين بدي أفهم
+
+660
+01:00:12,360 --> 01:00:18,530
+أكون فاهم أنها Cohort يعني مجموعة من الأولأخدوهم
+
+661
+01:00:18,530 --> 01:00:23,790
+وظلهم يتابعوا فيهم ويلاحقوهم وطبعا مع مرور الوقت
+
+662
+01:00:23,790 --> 01:00:30,690
+بتلاقي يعني ممكن أول سنة تسعين بالمية نلاقيهم نخسر
+
+663
+01:00:30,690 --> 01:00:35,690
+عشرة بالمية مثلا يعني والله مية ونهاية السنة كدرتش
+
+664
+01:00:35,690 --> 01:00:40,830
+إذا واحد بيقولك أول سنة أول مرة جبت مية يعني ركيت
+
+665
+01:00:40,830 --> 01:00:47,910
+المية شخص وتعاملت معهموبعد سنة أو عشر سنين وصلت
+
+666
+01:00:47,910 --> 01:00:53,250
+المية تماماً، بقولك مستحيل إلا يكون واحد مات، واحد
+
+667
+01:00:53,250 --> 01:00:57,690
+انتقل، واحد بطل يحب يشارك في الدراسة، وواحد فيه
+
+668
+01:00:57,690 --> 01:01:02,790
+عنده مشكلة، فمرات كثيرة بد الواحد ينتبه، فذولا
+
+669
+01:01:02,790 --> 01:01:09,950
+الستراتيجيات النقطة الآن، في أسئلة، يا دكتور أحمد
+
+670
+01:01:09,950 --> 01:01:16,540
+أو غيره، في حد عنده سؤالهي كان سؤال من كريم بخصوص
+
+671
+01:01:16,540 --> 01:01:21,260
+الجدول اللي كان قبل الـ «سلايد» السابق «الألترا
+
+672
+01:01:21,260 --> 01:01:25,720
+فاست» مش عارف قصده نسخة واحدة كافية يكون هي قصد
+
+673
+01:01:25,720 --> 01:01:30,880
+الجدول؟ آه هي قصد الجدول كانت إنه إذا واحدة Ultra
+
+674
+01:01:30,880 --> 01:01:37,920
+Fast شكلها كافية لهذا الأليل لهذا النوع من
+
+675
+01:01:37,920 --> 01:01:41,860
+الإنزيمات طبعاً بيكون في الغالب درسوه على دوة
+
+676
+01:01:41,860 --> 01:01:47,150
+معينةفاهم عليك كيف؟ فمرات، أه، بتكون، وطبعًا إذا
+
+677
+01:01:47,150 --> 01:01:52,310
+كانت سنتين ultra-fast يمكن يعني حاطين شحطة يعني مش
+
+678
+01:01:52,310 --> 01:01:56,650
+كاتبين إنه فيه بتصير حالات منها بس أه، بتكون سريع
+
+679
+01:01:56,650 --> 01:02:01,410
+جدًا يعني فبالتالي، بدك إذا عرفت إنه ultra-fast
+
+680
+01:02:01,410 --> 01:02:06,010
+وعطيته الدواء، ما راح يفيدك ما راح تحصل الاستجابة
+
+681
+01:02:06,010 --> 01:02:08,970
+المطلوبة لأنك أصلا ماوصلت للجرعة اللازمة بدك
+
+682
+01:02:08,970 --> 01:02:11,250
+تزودها يعني إذا عرفت، أه
+
+683
+01:02:15,520 --> 01:02:21,920
+الآن هذا جدول أنا بعتبره من أهم الجداول وحقيقة
+
+684
+01:02:21,920 --> 01:02:31,360
+يعني الواحد أنه بيفهمه لازم يعني ضروري لأي دكتور
+
+685
+01:02:31,360 --> 01:02:35,200
+لأنه لما الواحد يقرأ المقالات الإلمية يجب أن يكون
+
+686
+01:02:35,200 --> 01:02:40,020
+منتبه للنقطة هذه لما
+
+687
+01:02:40,020 --> 01:02:46,830
+نحن نتكلم مافيش إشي في الدنيا لازمحقيقي مية بالمية
+
+688
+01:02:46,830 --> 01:02:52,830
+مافيش إشي يعني أي في الـ MCQ's always and never
+
+689
+01:02:52,830 --> 01:02:57,910
+and always wrong مافيش إشي never مافيش إشي always،
+
+690
+01:02:57,910 --> 01:03:06,150
+ماشي؟ فلو جيت أنا أفرض أن أعمل تجربة وجبت مثلا
+
+691
+01:03:06,150 --> 01:03:12,410
+مجموعة معينة هو أنا الدراسة بيحكون عنها أنه بالأخر
+
+692
+01:03:12,410 --> 01:03:20,300
+Nالـ N هي العدد الكلي باجي بشوف، بكون عندي Gold
+
+693
+01:03:20,300 --> 01:03:24,700
+Standard بكون عندي طريقة أو أسلوب عشان أعرف المرض
+
+694
+01:03:24,700 --> 01:03:30,440
+موجود ولا مش موجود فبقسم الناس، في ناس عندهم المرض
+
+695
+01:03:30,440 --> 01:03:35,820
+وفي ناس ماعندهم مش المرض اللي عندهم المرض بالأخير
+
+696
+01:03:35,820 --> 01:03:39,540
+راح يقسموا Total Affected راح يكون الـ A زاد C
+
+697
+01:03:40,330 --> 01:03:45,190
+واللي ما عندهم مش المرض «unaffected» «BND» حيث أنه
+
+698
+01:03:45,190 --> 01:03:51,990
+المجموع الكل بيساوي «N» أي فحص عادةً ما بيكون إلا
+
+699
+01:03:51,990 --> 01:03:56,890
+100% كل اللي عندهم مرض لازم يصير عندهم الفحص يطلع
+
+700
+01:03:56,890 --> 01:04:02,630
+إيجابي، ما بيطلع هيك يعني لو حتى 99% ممتاز جداً
+
+701
+01:04:02,630 --> 01:04:11,770
+جداً جداً إذا لو 99% بيظل 1% بيطلع، مش هيكفلما
+
+702
+01:04:11,770 --> 01:04:17,510
+أدرس فحص معين والمثال هنا بالذات لـ Genotype معين
+
+703
+01:04:17,510 --> 01:04:22,450
+يعني بفحص أنا على وجود Gen محدد بالشكل هذا فإذا
+
+704
+01:04:22,450 --> 01:04:26,850
+الأليل بالشكل اللي أنا بظن أنه إله دخل فهذا بقول
+
+705
+01:04:26,850 --> 01:04:29,890
+هو الـ Susceptibility Genotype وبقول هو أنا طلعت
+
+706
+01:04:29,890 --> 01:04:34,870
+Positive أو Present حسب الـ Test راح يكون في
+
+707
+01:04:34,870 --> 01:04:38,370
+مجموعة ثانية Susceptibility Group Test Absent
+
+708
+01:04:39,710 --> 01:04:46,610
+الدنيا هيك فنتيجة الأمر هذا أنه فيه راح ينقسم عنده
+
+709
+01:04:46,610 --> 01:04:52,050
+الـ affected راح يصيروا A ال test طلعهم positive و
+
+710
+01:04:52,050 --> 01:04:57,130
+C ال test طلعهم negative واللي عندهم ماعندهم مش
+
+711
+01:04:57,130 --> 01:05:03,300
+المرض ال test لل B طلعهم positive راح يصير هيكوالـ
+
+712
+01:05:03,300 --> 01:05:09,440
+Negative اللي يكون المفروض الغالب يطلعهم الـ Test
+
+713
+01:05:09,440 --> 01:05:15,940
+Negative بس مجموعهم بهذا الشكل وهنا المجموع الفرقي
+
+714
+01:05:15,940 --> 01:05:20,380
+للـ Positive Test اللي هم الـ A والـ B True
+
+715
+01:05:20,380 --> 01:05:28,020
+Positive وFalse Positive والـ C الـ False Negative
+
+716
+01:05:28,020 --> 01:05:34,950
+وFalse Positiveالـ C الـ False Negative والـ D هم
+
+717
+01:05:34,950 --> 01:05:41,590
+الـ True Negative فذولا المجموع بساول N لو أخدت
+
+718
+01:05:41,590 --> 01:05:48,650
+هذا الجدول لعلاقة الـ Test بالـ Disease بقدر أتكلم
+
+719
+01:05:48,650 --> 01:05:55,190
+على النقاط اللي بعدها فذولا نقاط مهم كثير كل واحد
+
+720
+01:05:55,190 --> 01:06:00,910
+منهم راح أجيبلكم إياها في الامتحانماشي، وما دخلناش
+
+721
+01:06:00,910 --> 01:06:05,350
+100% بالـ Genetics بقدر ما أنه هنا حتى نتكلم عن
+
+722
+01:06:05,350 --> 01:06:11,910
+الـ Statistics والإحصاء والـ Epidemiology طب
+
+723
+01:06:11,910 --> 01:06:15,710
+المجتمع فالنقاط
+
+724
+01:06:15,710 --> 01:06:18,410
+التعريفات هذه مهمة كثير الـ Frequency of
+
+725
+01:06:18,410 --> 01:06:23,210
+Susceptibility of Genes اللي هم الـ A والـ B على
+
+726
+01:06:23,210 --> 01:06:30,860
+الـ M يعني كام نسبة الناس طلعواPositive، أيوة يا
+
+727
+01:06:30,860 --> 01:06:35,000
+كريم ممكن تحيط دكتور رجستر الـ Positive والـ
+
+728
+01:06:35,000 --> 01:06:41,140
+Negative فوق في الجدولة؟ شوف، أنا افرض عندي مرض،
+
+729
+01:06:41,140 --> 01:06:49,820
+ماشي؟ وعندي test أنا بعرف أني أنا بستخدمه يعني راح
+
+730
+01:06:49,820 --> 01:06:55,820
+ناخد أمثلة عليهم، ماشي؟ فالـ Test لما نكون إنسان
+
+731
+01:06:55,820 --> 01:07:02,730
+مصابلو فرضنا قوة هذا الـ Test 99%، ماذا سيحصل؟
+
+732
+01:07:02,730 --> 01:07:09,270
+سيحصل أن البشر اللي بفحصهم 99%، المية الذولة اللي
+
+733
+01:07:09,270 --> 01:07:12,290
+بفحصهم أنهم كانوا Positive، كان عندهم المرض
+
+734
+01:07:12,290 --> 01:07:17,850
+الغالبية العظمة يفترض أنه سيحصل عندهم Positive بس
+
+735
+01:07:17,850 --> 01:07:23,750
+بظل جزء بسيط منهم بتبين معاهم الـ Test Negative،
+
+736
+01:07:23,750 --> 01:07:29,170
+ولو أنه عنده المرضيعني أنا مثلًا مرات حتى تفهموا
+
+737
+01:07:29,170 --> 01:07:34,470
+العلاقات بين الأشياء مثلًا بأجي بقول أنا بفحص مرض
+
+738
+01:07:34,470 --> 01:07:42,070
+السكري عن طريق يعني بنشخص احنا مرض السكري عن طريق
+
+739
+01:07:42,070 --> 01:07:50,610
+فحص سكر الدم، لما أنا أجيلما أقول، وإيها دخل في
+
+740
+01:07:50,610 --> 01:07:55,070
+التعريف لأن إيها دخل بعدين بالـ Sensitivity والـ
+
+741
+01:07:55,070 --> 01:07:59,750
+Specificity اللي سنحكي عنهم لما أقول أنا والله
+
+742
+01:07:59,750 --> 01:08:04,890
+اللي باخد أنا كتعريف السكري الإنسان اللي سكريه
+
+743
+01:08:04,890 --> 01:08:10,710
+طبيعي اللي هو تحت 126 ميلي جرام per deciliter هذا
+
+744
+01:08:10,710 --> 01:08:16,010
+بعتبره إنسان طبيعيواللي فوق 126 أو 141 حسب
+
+745
+01:08:16,010 --> 01:08:21,130
+التعريفات للمرض السكري بعتبر إن هذا عنده سكري
+
+746
+01:08:21,130 --> 01:08:25,550
+وبقول هذا عنده المرض فإحنا هنا أخذنا قراءة رقم
+
+747
+01:08:25,550 --> 01:08:32,630
+السكر كـ Test للسكري، صح؟ ماشي معاه يا كريم؟ معاك
+
+748
+01:08:32,630 --> 01:08:37,410
+سيد الدكتور طيب، افرض مريض سكري أجى يوم الفحص لسبب
+
+749
+01:08:37,410 --> 01:08:44,540
+ما زبط معاهما أكلش بالليل، ارتبك، عمل رياضة، اشتغل
+
+750
+01:08:44,540 --> 01:08:49,220
+يحلف بالأرض، وظبط السكري معاه، وثاني يوم هو مريض
+
+751
+01:08:49,220 --> 01:08:54,160
+سكري، هو بشكي، بعطشان، وببول، وبشرب ميه كتير،
+
+752
+01:08:54,160 --> 01:08:58,440
+وتعبان، ومرهق، وكذا، هو فعلا عنده سكري لو فحصته
+
+753
+01:08:58,440 --> 01:09:01,900
+بالـHemoglobin A1C، بس يوم ما راح يعمل الفحص
+
+754
+01:09:01,900 --> 01:09:07,880
+…‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏
+
+755
+01:09:10,280 --> 01:09:16,060
+صحيح هذا جزء منه بس الفكرة أنه لو أخدت مثال أنا
+
+756
+01:09:16,060 --> 01:09:21,380
+عشان أشرح المثال اللي حاطينهإنه بيقول مرضى السكري
+
+757
+01:09:21,380 --> 01:09:24,060
+أنا عنده الـGold Standard بالـHemoglobin A1C
+
+758
+01:09:24,060 --> 01:09:28,340
+وبعيده مرتين عشان أتأكد وعندي أسلوب وكذا وكذا بس
+
+759
+01:09:28,340 --> 01:09:32,440
+افرض إن أنا هيك جيت على عشرة جاعدين أو عشرين
+
+760
+01:09:32,440 --> 01:09:35,580
+جاعدين مرضى السكري قتياري وكلهم أنا عارف هم عندهم
+
+761
+01:09:35,580 --> 01:09:40,080
+زكري وجيت أقول بدي أعمل فحص السكر هذا طريقة جديدة
+
+762
+01:09:40,080 --> 01:09:45,240
+عشان أشوف ولا طريقة عشان أشوفرح يصير أنه مثلًا
+
+763
+01:09:45,240 --> 01:09:49,060
+الغالبية العظمة اللي عندهم سكري بتوقع أنه راح يطلع
+
+764
+01:09:49,060 --> 01:09:55,940
+لأنه Normal Distribution اللي هو التوزيع
+
+765
+01:09:55,940 --> 01:09:59,680
+الطبيعي للأشياء فراح يظل فيه جزء من اللي عندهم
+
+766
+01:09:59,680 --> 01:10:04,620
+سكري يوم ما أنت تفحص وراح يطلع Normal فهذا راح
+
+767
+01:10:04,620 --> 01:10:12,610
+يكون False Negative فهم علي؟ اللي هو الـDأسف اللي
+
+768
+01:10:12,610 --> 01:10:17,990
+هو الـ C اللي هو إنه إنسان affected بس ال test
+
+769
+01:10:17,990 --> 01:10:22,310
+بهاي لحظة ما طلع ليها positive فاهم عليك كيف؟
+
+770
+01:10:22,310 --> 01:10:29,870
+فهدولة ال A true positive ال D true negative ال C
+
+771
+01:10:29,870 --> 01:10:34,730
+لأنه هو affected بس ال test طلع ليها negative فهو
+
+772
+01:10:34,730 --> 01:10:39,070
+false negative هذا إنسان false negative ومصاب بس
+
+773
+01:10:39,070 --> 01:10:44,550
+ما طلع ليها ال testوالـ B هو الـ False Positive هو
+
+774
+01:10:44,550 --> 01:10:50,050
+إنسان مش مصاب بس واحد مثلا أكل كثير بهالليل قبل ما
+
+775
+01:10:50,050 --> 01:10:54,690
+يروح يعمل الفحص ماكانش صايم مظبوط صار عنده stress
+
+776
+01:10:54,690 --> 01:11:00,930
+والهرمون كان عالي عنده ارتفاع السكري فدايماً هدولة
+
+777
+01:11:00,930 --> 01:11:07,200
+يعني إحنا بنقسم الناس بالنسبة للمرض وللـ TestTrue
+
+778
+01:11:07,200 --> 01:11:10,540
+Positive وTrue Negative وFalse Positive وFalse
+
+779
+01:11:10,540 --> 01:11:15,100
+Negative، وهكذا تكون الدنيا عندما نقول إنه في عندي
+
+780
+01:11:15,100 --> 01:11:19,620
+Susceptibility Genotype هو الـ A زائد B على الـ N
+
+781
+01:11:19,620 --> 01:11:27,370
+نسبة الـ Positives، يعني بقول إنهلما أنتيجة أحسب
+
+782
+01:11:27,370 --> 01:11:32,630
+فداش نسبة الـ test positive عند المرض الـ test
+
+783
+01:11:32,630 --> 01:11:35,850
+positive الـ true positive و الـ false positive
+
+784
+01:11:35,850 --> 01:11:39,670
+بأخدهم فبأخد الـ A والـ B على الـ N هاي الـ
+
+785
+01:11:39,670 --> 01:11:43,990
+frequency of the susceptibility الجينotype نحسبها
+
+786
+01:11:43,990 --> 01:11:48,490
+هي الـ disease prevalence شو احتمالية وجود المرض
+
+787
+01:11:48,490 --> 01:11:54,290
+اللي هو A زات C على الـ N ماشي؟فيه شيء اسمه الـ
+
+788
+01:11:54,290 --> 01:11:59,270
+Relative Risk Ratio اللي هو بالشكل هذا المعادلات
+
+789
+01:11:59,270 --> 01:12:03,630
+هذه مهمة Disease prevalence in carriers of
+
+790
+01:12:03,630 --> 01:12:06,950
+susceptibility genotype على Disease prevalence in
+
+791
+01:12:06,950 --> 01:12:12,690
+non-carriers of susceptibility genotype فبتكون هذه
+
+792
+01:12:12,690 --> 01:12:17,410
+Relative Risk Ratio بهذه الطريقة المهم كتير
+
+793
+01:12:17,410 --> 01:12:22,890
+بنسمعها Sensitivity وSpecificity Sensitivityهو
+
+794
+01:12:22,890 --> 01:12:27,310
+قدّاش Positive من اللي عنده المرض فاللي عنده المرض
+
+795
+01:12:27,310 --> 01:12:34,630
+A زي C اللي Test طلّعهم Positive الـ A فالـ A على
+
+796
+01:12:34,630 --> 01:12:41,050
+الـ A زي C هي Sensitivity وSpecificity للعكس، شو
+
+797
+01:12:41,050 --> 01:12:47,530
+نثبت أنه اللي Test طلّعهم Negative يكونوا فعلاً
+
+798
+01:12:47,530 --> 01:12:55,190
+True Negative مش False Negativeفنسبة الـ D على الـ
+
+799
+01:12:55,190 --> 01:12:59,570
+BND اللي هو الـ Unaffected وفيه الـ Positive
+
+800
+01:12:59,570 --> 01:13:02,930
+Predictive Value فهي معدلتها والـ Negative
+
+801
+01:13:02,930 --> 01:13:07,470
+Predictive Value طلع عليهم، اقرؤوهم، مهم كثير
+
+802
+01:13:07,470 --> 01:13:11,870
+وجوانب مهمة النقطة الأساسية اللي يعني اللي واحد
+
+803
+01:13:11,870 --> 01:13:17,110
+بدي يفهمها ليه إنه الـ Sensitivity وSpecificity
+
+804
+01:13:17,110 --> 01:13:25,550
+تناسبهم عكسي يعنيأنا مثلًا الـ Diagnostic Cut-off
+
+805
+01:13:25,550 --> 01:13:32,310
+Level للديابتس 126 milligram per deciliter رقم
+
+806
+01:13:32,310 --> 01:13:36,630
+معين بدي أحطه هو الـ Cut-off أشان أقول أعلى منه
+
+807
+01:13:36,630 --> 01:13:40,550
+عنده سكري أو أعطى منه ما عنده السكري ففي الحالة
+
+808
+01:13:40,550 --> 01:13:50,290
+هذه لو أنا قلت بدي أخلي الرقم هذا 140 141 الأن
+
+809
+01:13:50,650 --> 01:13:58,170
+في حالة الـ 141 شو استفدت؟ استفدت إن اللي ما عندهم
+
+810
+01:13:58,170 --> 01:14:05,470
+مش سكري ولسبب ما وصل الـ 126 نادر أقل حدوثا أنه
+
+811
+01:14:05,470 --> 01:14:09,870
+وصل الـ 140 فأنا بزود الـ Sensitivity تبع الـ Test
+
+812
+01:14:09,870 --> 01:14:14,130
+في مقابل إنه بقلل الـ Sensitivityبزيد الـ
+
+813
+01:14:14,130 --> 01:14:17,190
+Specificity، راح أقلل الـ Sensitivity، والعكس
+
+814
+01:14:17,190 --> 01:14:22,510
+بالعكس وبتطلع عليها وشغل مفهوم يعني إن شاء الله بس
+
+815
+01:14:22,510 --> 01:14:27,170
+الأهم يعني هدولة الخمس الـ Definitions أو ست الـ
+
+816
+01:14:27,170 --> 01:14:34,670
+Definitions هدولة مهمات كثير وابصموهم بصمي لما
+
+817
+01:14:34,670 --> 01:14:38,790
+ناخد مثال على هذا الموضوع أنا بأجي مثلا الـ Colon
+
+818
+01:14:38,790 --> 01:14:42,980
+Cancerالـ Colon Cancer بشخصه مثلاً إن أعمل
+
+819
+01:14:42,980 --> 01:14:47,740
+colonoscopy و أروح أدور جوا و أتطلع على القلون تبع
+
+820
+01:14:47,740 --> 01:14:51,460
+الإنسان هذا وهنا بأعطوك إنه عملوا الدراسة هذه
+
+821
+01:14:51,460 --> 01:14:57,420
+عوالي 4500 بني آدم يعني عملوا colonoscopy و دوروا
+
+822
+01:14:57,420 --> 01:15:04,160
+مظبوط و اتأكدوا مين affected طلع من الـ 4500 طلعوا
+
+823
+01:15:04,160 --> 01:15:09,340
+45 واحد يعني واحد بالمية طلعت، ممكن أكبر بالعمر
+
+824
+01:15:09,960 --> 01:15:16,680
+وطلعت هالجدّة الـ Positive الـ Negative أربع تلاف
+
+825
+01:15:16,680 --> 01:15:20,960
+وأربع مية وخمسين هدولة الـ Negative البقية لكل
+
+826
+01:15:20,960 --> 01:15:24,620
+أربع تلاف وخمسمية تقريبًا من المجموعتين هذا يعني
+
+827
+01:15:24,620 --> 01:15:28,740
+هنا واحد بالمية وهنا تقريبًا تسعة وتسعين بالمية
+
+828
+01:15:28,740 --> 01:15:35,500
+فبنقعد أشوف الـ Test شو عمل اللي أنا بدرس على اللي
+
+829
+01:15:35,500 --> 01:15:44,260
+هو يعني قليل معينوبكون في موقع معين 1307 مثلًا بين
+
+830
+01:15:44,260 --> 01:15:52,700
+Lycine وIsoleucine بين أليلين نتاج بلاقيها بهذا
+
+831
+01:15:52,700 --> 01:15:57,060
+الشكل أنا باعتبر الـSusceptibility gene اللي هو
+
+832
+01:15:57,060 --> 01:16:03,720
+Lycine 1307 لأ الـSusceptibility gene اللي هو
+
+833
+01:16:03,720 --> 01:16:11,340
+Isoleucine بهذا الشكللما أجي، أنا أشوف الـ
+
+834
+01:16:11,340 --> 01:16:17,940
+Relative Risk Ratio للقليل اللي هو التبع ABC اللي
+
+835
+01:16:17,940 --> 01:16:21,580
+هو يعني نوع من، يعني هذا هو الجين الأقوى والأهم
+
+836
+01:16:21,580 --> 01:16:28,540
+للتشخيص فلما أشوف الـ Relative Risk Ratio RRR
+
+837
+01:16:28,540 --> 01:16:34,300
+نقراها كثير، نحسبها من الأرقام هذه تطلع 2.4 يعني
+
+838
+01:16:34,300 --> 01:16:38,820
+مرتين ونص، إذا عندك هذا الإشي بتكونأي احتماليتك
+
+839
+01:16:38,820 --> 01:16:47,620
+أكتر إنك يكون عندك المرض الـ Sensitivity
+
+840
+01:16:47,620 --> 01:16:55,280
+16% الـ Specificity 93% الـ Positive Predictive
+
+841
+01:16:55,280 --> 01:17:01,500
+Value 2% الـ Negative Predictive Value 99% هاي
+
+842
+01:17:01,500 --> 01:17:05,720
+أرقام النقطة
+
+843
+01:17:05,720 --> 01:17:11,020
+هذهيعني اللي
+
+844
+01:17:11,020 --> 01:17:20,240
+بدنا نتكلم عليها اللي هي حقيقة إنه يعني هنا بنتكلم
+
+845
+01:17:20,240 --> 01:17:25,740
+عن إحصاء بنتكلم عن معلومات محددة على مثال محدد بس
+
+846
+01:17:25,740 --> 01:17:30,180
+المبدأ يعني النقطة الأولى اللي هي إنه الـ
+
+847
+01:17:30,180 --> 01:17:34,200
+sensitivity و specificity علاقتهم مع بعض عكسية
+
+848
+01:17:35,490 --> 01:17:39,270
+الناحية الثانية المهمة أحيانًا يعني أنا مثلًا بضرب
+
+849
+01:17:39,270 --> 01:17:46,690
+لكم مثال يعني نستخدمه سريريا حتى إنه إذا أنا عندي
+
+850
+01:17:46,690 --> 01:17:54,650
+حالة وعندي مرض وعندي شغل معين ممكن إني أكون يعني
+
+851
+01:17:54,650 --> 01:18:02,190
+زي ما بقولوا الـ وين أهميتها تعتمد على قداش المرض
+
+852
+01:18:02,190 --> 01:18:07,010
+موجود ضمن ال population هذهاللي هي الـ Prevalence
+
+853
+01:18:07,010 --> 01:18:13,470
+كل مكان نادر جداً ماشي اللي بيصير قيمة الـ False
+
+854
+01:18:13,470 --> 01:18:17,190
+Positive يعني شخص مش مصاب اللي هو الغربي العظمى
+
+855
+01:18:17,190 --> 01:18:21,630
+بيصير دورها أكبر وهنا يعني حاطينك مثال الـ
+
+856
+01:18:21,630 --> 01:18:25,910
+Positive Predictive Value Very Poor 8% بس الـ
+
+857
+01:18:25,910 --> 01:18:31,470
+Negative Predictive Value هي المهمة 99% يعني شو؟
+
+858
+01:18:31,470 --> 01:18:36,580
+يعني مثلاًيعني مثال مشهور جداً ولازم الناس تعرفه
+
+859
+01:18:36,580 --> 01:18:41,720
+اللي عندهم جلطات بالأوردة من الفحوصات إذا ما فيه
+
+860
+01:18:41,720 --> 01:18:46,280
+جلطة بيصير Clotting والـ Clotting فيه Fibrin الـ
+
+861
+01:18:46,280 --> 01:18:50,440
+Fibrin بتم تحطيمه ففيه بيسموه Fibrin Degradation
+
+862
+01:18:50,440 --> 01:18:57,180
+Product، ماشي؟ هذولة، ماشي عند الجلطة بيكون مرتفعة
+
+863
+01:18:57,180 --> 01:19:01,620
+كثير بس في أشياء كثيرة برضه بترفعه وبالتالي قيمته
+
+864
+01:19:02,300 --> 01:19:07,840
+في حالة ما أنه positive مالوش قيمة كثير بس اللي
+
+865
+01:19:07,840 --> 01:19:14,980
+ماعندهوش جلطة ماشي اللي ماعندهوش جلطة بتلاقي الـ
+
+866
+01:19:14,980 --> 01:19:21,860
+يعني الـ الـ إن الـ D-Dimer هذا بتلاقيه negative
+
+867
+01:19:21,860 --> 01:19:28,770
+فاحنا يعني دائما بنقول للمقيمين والدكاترةإنه دور
+
+868
+01:19:28,770 --> 01:19:32,210
+لما تعمل الـ D-Dimer مش تدوره عشان تثبت إنه هي
+
+869
+01:19:32,210 --> 01:19:36,750
+جلطة أنت بتعمله عشان يعني واحد عنده مثلا فشل كلوي
+
+870
+01:19:36,750 --> 01:19:41,910
+الـ D-Dimer راح يظل مرتفع، ماشي بس أنا بتكلم على
+
+871
+01:19:41,910 --> 01:19:47,930
+إنه اللي ما عندهم مش المرض راح تلاقي نسبة اللي
+
+872
+01:19:47,930 --> 01:19:53,290
+عندهم مرتفعة متدنية جدا فبالتالي أحياناً المهم من
+
+873
+01:19:53,290 --> 01:19:56,110
+الفحص اللي هو الـ Negative Predictive Value فهي
+
+874
+01:19:56,110 --> 01:20:00,640
+بتكون هي المهمةهذا الموضوع ممكن ندخله كمان على
+
+875
+01:20:00,640 --> 01:20:12,720
+أكثر من جين مشترك فهنا تنظير نظري عن الـ Relative
+
+876
+01:20:12,720 --> 01:20:18,100
+Risk لثلاث جينات مع الـ Disease Frequency فإذا فيه
+
+877
+01:20:18,100 --> 01:20:22,400
+combination من ثلاثة الـ Relative Risk مثلاً نسبة
+
+878
+01:20:22,400 --> 01:20:26,420
+عالية جداً، 50% من الـ Population بينما لما نكون
+
+879
+01:20:26,420 --> 01:20:29,320
+الثلاثة Negativeالـ Relative risk is very-very
+
+880
+01:20:29,320 --> 01:20:39,460
+weak اللي هي 0.05% يعني خمسة بالألف الفكرة مثلا،
+
+881
+01:20:39,460 --> 01:20:45,060
+أنا باجي يعني ليه بدي أفرقها بين أهمية الفحص كـ
+
+882
+01:20:45,060 --> 01:20:49,140
+Screening لـ Population و لـ Diagnostic Test هون
+
+883
+01:20:49,140 --> 01:20:54,700
+أحطي مثال اللي هو الأبو شيء معين بدرسوه في حالة
+
+884
+01:20:54,700 --> 01:20:59,920
+الـ Alzheimerفأنا، يعني أنا عندي هذا الـ Test
+
+885
+01:20:59,920 --> 01:21:05,940
+ودخلناه في غزة وبستطيع إن أنا أستخدمه إذا بروح
+
+886
+01:21:05,940 --> 01:21:10,240
+أعمل فيه Population Screening يعني باجي عن جنب
+
+887
+01:21:10,240 --> 01:21:15,380
+وطرف كل اللي أعمارهم من 65 إلى 74 سنة باجي بفحصهم
+
+888
+01:21:15,380 --> 01:21:20,680
+إذا كان الـ Prevalence للـ Population للـ
+
+889
+01:21:20,680 --> 01:21:30,870
+Alzheimer Disease 3%النتيجة أن قيمة الفحص سيئة لدي
+
+890
+01:21:30,870 --> 01:21:35,590
+لأن المرض ليس متواجدًا وغالبًا اللي سيصبح Positive
+
+891
+01:21:35,590 --> 01:21:41,130
+الـ Positive Predictive Value ستكون 6% وإذا كان
+
+892
+01:21:41,130 --> 01:21:43,650
+شيء آخر 23%، فهو نسبة قليلة
+
+893
+01:21:47,090 --> 01:21:51,530
+فالأهمية الموضوع هذا أنه أمتى هل عندي إشي أنا ..
+
+894
+01:21:51,530 --> 01:21:55,190
+يعني يمكن هيقبلها لو كان أنا بقدر أسوي إشي بس هذه
+
+895
+01:21:55,190 --> 01:22:00,790
+الحالة وهذه المرض وهذه الإشي عادة ما عندي أني أنا
+
+896
+01:22:00,790 --> 01:22:07,850
+أعمله إشي وأفيده طبعا الـ False Positive اللي
+
+897
+01:22:07,850 --> 01:22:12,390
+ماعندوش مرض وطلعت test عنده positive راح يدخل في
+
+898
+01:22:12,390 --> 01:22:19,700
+قلمنفسي وقلم، يعني أنا بكربه بسويله كرب، بسويله
+
+899
+01:22:19,700 --> 01:22:25,420
+مرض أنه أكون أقول له أنه «انت ال test طالع عندك
+
+900
+01:22:25,420 --> 01:22:28,820
+positive و الله خلينا نعمل فحص أكثر» أو «يمكن أنك
+
+901
+01:22:28,820 --> 01:22:32,520
+تكون معرض للشغل هذه بعدين» أو «يمكن أوتره، يمكن
+
+902
+01:22:32,520 --> 01:22:38,820
+أمرضه» والناحية الثانية أنه ال test بهذا الشكل راح
+
+903
+01:22:38,820 --> 01:22:43,120
+يكون لما يواحد يطلع negative ما هو مالوش قيم كثير،
+
+904
+01:22:43,120 --> 01:22:47,690
+لأنه أصلاًالمرض مش كثير، بس هذا الـ test مش كويس
+
+905
+01:22:47,690 --> 01:22:52,430
+فهو بيصير false reassurance اللي بيطلعوا negative
+
+906
+01:22:52,430 --> 01:22:57,390
+فهي لما نكون أنا استخدمت هذا الفحص اللي هو مش
+
+907
+01:22:57,390 --> 01:23:03,850
+مناسب ك screening test لل population ال screening
+
+908
+01:23:03,850 --> 01:23:12,560
+test بنحاول يكون sensitive ال .. ال ..الثاني الـ
+
+909
+01:23:12,560 --> 01:23:15,520
+Diagnostic Test اللي بيثبت المرض لازم يكون
+
+910
+01:23:15,520 --> 01:23:24,700
+Specific يعني لو جيت أنا على حالة ثانية نفس الـ
+
+911
+01:23:24,700 --> 01:23:32,400
+Test الأب وهذا وجيت طبقته على المجموعة اللي من 65
+
+912
+01:23:32,400 --> 01:23:39,110
+لـ 74 بس عندهم عراضي الخرف الـ Dementiaهذه مجموعة
+
+913
+01:23:39,110 --> 01:23:42,910
+مصابة مثلًا مثلًا مدينة جنكول تعمل تجارب الـ HIV
+
+914
+01:23:42,910 --> 01:23:48,170
+لكل الناس طب ما الـ HIV مرتفعة جدًا وأجي أنا أعمله
+
+915
+01:23:48,170 --> 01:23:51,370
+راح يطلع غالبيت اللي بطلع positive راح يكونوا أصلا
+
+916
+01:23:51,370 --> 01:23:55,350
+هم negative وهي false positive فرح أنا أكرب الناس
+
+917
+01:23:55,350 --> 01:23:59,150
+وأشغلهم وكذا وكذا وبالأخير مايستفيدوش ويكون فيها
+
+918
+01:23:59,150 --> 01:24:03,310
+مشاكل هنا مثلًا روحت على مجموعة المساجين في السجن
+
+919
+01:24:03,310 --> 01:24:08,080
+والله ال incidents يمكن تكون أعلىبعضهم اتناول
+
+920
+01:24:08,080 --> 01:24:12,620
+مخدرات بعضهم عمل مشاكل سلوك وغير سوي أو اللي هو
+
+921
+01:24:12,620 --> 01:24:16,780
+كذا وعرضهم للشغل فمن أعمل الـ Test وقتها حتى لو
+
+922
+01:24:16,780 --> 01:24:21,120
+كان مش 100% طبعاً ومش راح يكون فيه إشي مش 100%
+
+923
+01:24:21,120 --> 01:24:26,160
+فهتكون أفضل بكتير ففي الحال الثاني هذه راح نلاقي
+
+924
+01:24:26,160 --> 01:24:31,120
+إنه الـ Positive Predictive Value 75% الـ Negative
+
+925
+01:24:31,120 --> 01:24:40,440
+Predictive Value أو إذا فيه إشي 98%فالفكرة هنا لو
+
+926
+01:24:40,440 --> 01:24:43,560
+أنا استخدمته في الـ population اللي كويسة المجموع
+
+927
+01:24:43,560 --> 01:24:46,940
+اللي كويسة أروح أعمل هذا الفحص كـ Diagnostic Test
+
+928
+01:24:46,940 --> 01:24:53,920
+راح يكون أنا بصير والله يعجبني أكثر الموضوع إذا
+
+929
+01:24:53,920 --> 01:24:57,310
+طلع Negativeإذا طلع Negative وعندي أنا هذا
+
+930
+01:24:57,310 --> 01:25:01,530
+Positive predictive value 98 وكذا ففاقت الـ Test
+
+931
+01:25:01,530 --> 01:25:05,250
+إني أنا لما أشوفه Negative أروح أقول هاي مش
+
+932
+01:25:05,250 --> 01:25:09,170
+Dementia خليني أروح أدور على سبب ثاني غير الحالة،
+
+933
+01:25:09,170 --> 01:25:18,590
+هذه بالطريقة هذه فالأمور هذه يعني الـ Test ممكن
+
+934
+01:25:18,590 --> 01:25:21,410
+كمان يكون الـ heterozygous أظن أن هذا الـ slide
+
+935
+01:25:21,410 --> 01:25:25,640
+الأخيروبكون إنه للـ Cystic Fibrosis مثلًا بيهمني
+
+936
+01:25:25,640 --> 01:25:28,720
+أني أدرس الموضوع لأن فيه في الـ population
+
+937
+01:25:28,720 --> 01:25:34,920
+اختلافات فالـ Career Testing الأصل مثلًا في الـ
+
+938
+01:25:34,920 --> 01:25:43,520
+Whites للجين 1 في 25 فلما يكون 1 في 25 بضربوا بعض
+
+939
+01:25:43,520 --> 01:25:49,760
+25 في 25 بطلع 3200 تقريبًا يعني، هيك يعني اللي هي
+
+940
+01:25:49,760 --> 01:26:00,900
+الـ Incidence of Cystic Fibrosisالـ Career Status
+
+941
+01:26:00,900 --> 01:26:05,880
+بتكون يعني شوفوا الأرقام، اتطلع عليها ممكن نكمل
+
+942
+01:26:05,880 --> 01:26:09,880
+المحاضرة الجاية بهذا الجزء قبل ما ندخل على الـ
+
+943
+01:26:09,880 --> 01:26:13,480
+Genetics أنا لازم أطلع عندي هسه شغل ثاني فالله
+
+944
+01:26:13,480 --> 01:26:17,300
+يوفقكم وإذا حد عنده أسئلة يحط على الـ Group أو
+
+945
+01:26:17,300 --> 01:26:23,340
+يذكرنا فيها بداة المحاضرة القادمةماشي الحاجة الله
+
+946
+01:26:23,340 --> 01:26:26,020
+يرضى عليكم نشوفكم بخير ان شاء الله
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/hUu77dlYhF8_raw.json b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/hUu77dlYhF8_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..287ea2de7b97a271be5dcb5b4fab13c854da3336
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/hUu77dlYhF8_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 3465, "start": 6.51, "end": 34.65, "text": "بسم الله الرحمن الرحيم أهياركم الله ونبدأ إن شاء الله المحاضرة فبنبدأ نسأل في أي حد عنده استفسار عن النقاط اللي قبل؟ في أي أسئلة؟ في أي شيء؟ إحنا إن شاء الله يوم الجمعة هيكون chapters تمانية وتسعة أو عشرة أو أحداشر", "tokens": [3555, 38251, 21984, 34892, 5016, 27842, 34892, 5016, 32640, 5551, 3224, 1829, 9640, 24793, 21984, 4032, 1863, 44510, 10721, 36145, 13412, 16606, 21984, 9673, 5016, 46958, 25720, 6156, 3555, 1863, 44510, 10721, 8717, 3794, 10721, 1211, 8978, 36632, 11331, 3215, 43242, 3224, 44713, 36178, 9640, 18871, 28239, 4587, 41193, 13672, 1829, 12174, 36150, 22807, 8978, 36632, 5551, 3794, 19986, 37977, 22807, 8978, 36632, 44049, 38207, 22807, 11933, 5016, 8315, 36145, 13412, 16606, 21984, 7251, 20498, 25724, 2304, 27884, 39896, 30544, 20013, 46811, 7649, 10632, 34683, 3794, 27884, 34051, 6225, 8592, 25720, 34051, 5551, 24401, 33599, 2288], "avg_logprob": -0.16172679920786434, "compression_ratio": 1.8762376237623761, "no_speech_prob": 1.0132789611816406e-06, "words": [{"start": 6.51, "end": 7.13, "word": "بسم", "probability": 0.80908203125}, {"start": 7.13, "end": 7.37, "word": " الله", "probability": 0.951171875}, {"start": 7.37, "end": 7.95, "word": " الرحمن", "probability": 0.9832356770833334}, {"start": 7.95, "end": 8.57, "word": " الرحيم", "probability": 0.9954427083333334}, {"start": 8.57, "end": 11.51, "word": " أهياركم", "probability": 0.703955078125}, {"start": 11.51, "end": 11.93, "word": " الله", "probability": 0.94921875}, {"start": 11.93, "end": 13.11, "word": " ونبدأ", "probability": 0.8837890625}, {"start": 13.11, "end": 13.31, "word": " إن", "probability": 0.58349609375}, {"start": 13.31, "end": 13.43, "word": " شاء", "probability": 0.9921875}, {"start": 13.43, "end": 13.65, "word": " الله", "probability": 0.96630859375}, {"start": 13.65, "end": 14.83, "word": " المحاضرة", "probability": 0.98193359375}, {"start": 14.83, "end": 15.99, "word": " فبنبدأ", "probability": 0.81552734375}, {"start": 15.99, "end": 16.71, "word": " نسأل", "probability": 0.93115234375}, {"start": 16.71, "end": 17.19, "word": " في", "probability": 0.31396484375}, {"start": 17.19, "end": 17.49, "word": " أي", "probability": 0.84375}, {"start": 17.49, "end": 17.77, "word": " حد", "probability": 0.972900390625}, {"start": 17.77, "end": 18.11, "word": " عنده", "probability": 0.9892578125}, {"start": 18.11, "end": 18.73, "word": " استفسار", "probability": 0.97607421875}, {"start": 18.73, "end": 18.95, "word": " عن", "probability": 0.98291015625}, {"start": 18.95, "end": 19.47, "word": " النقاط", "probability": 0.96044921875}, {"start": 19.47, "end": 19.67, "word": " اللي", "probability": 0.974609375}, {"start": 19.67, "end": 22.21, "word": " قبل؟", "probability": 0.8468424479166666}, {"start": 22.21, "end": 23.85, "word": " في", "probability": 0.69873046875}, {"start": 23.85, "end": 24.19, "word": " أي", "probability": 0.93408203125}, {"start": 24.19, "end": 25.15, 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{"start": 2049.3, "end": 2050.16, "word": " كريم", "probability": 0.8553059895833334}, {"start": 2050.16, "end": 2055.34, "word": " ماشي", "probability": 0.8527018229166666}, {"start": 2055.34, "end": 2060.28, "word": " فالنقطة", "probability": 0.792822265625}, {"start": 2060.28, "end": 2060.5, "word": " اللي", "probability": 0.967529296875}, {"start": 2060.5, "end": 2061.02, "word": " بدنا", "probability": 0.408935546875}, {"start": 2061.02, "end": 2061.62, "word": " نذكرها", "probability": 0.982666015625}, {"start": 2061.62, "end": 2063.0, "word": " إنه", "probability": 0.767578125}, {"start": 2063.0, "end": 2064.48, "word": " تعامل", "probability": 0.9366861979166666}, {"start": 2064.48, "end": 2065.6, "word": " الأدوية", "probability": 0.9945068359375}, {"start": 2065.6, "end": 2067.14, "word": " بسبب", "probability": 0.90478515625}, {"start": 2067.14, "end": 2067.8, "word": " الوراثة", "probability": 0.9732421875}, {"start": 2067.8, "end": 2068.38, "word": " وتعامل", 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"seek": 215902, "start": 2130.16, "end": 2159.02, "text": "العمليات الكيميائية بتتم في الكبد سبحان الله كيف خلق الله للإنسان وكيف الكبد والكبد يعني ميزته إنه إذا أكلت شيء أو شربت شيء أو دخل شيء في الأمعاء لازم يمر على الكبد قبل ما يدخل لبقية الجسم ففي شيء بيسموه، عرفته عنه اسمه الـ First Pass Metabolism فإحنا بنقسم الناس أحيانًا لبعض الأدوية", "tokens": [6027, 25957, 20292, 9307, 33251, 32640, 1829, 16373, 10632, 39894, 39237, 8978, 33251, 44510, 8608, 49628, 7649, 21984, 9122, 33911, 16490, 1211, 4587, 21984, 24976, 28814, 1863, 3794, 7649, 4032, 4117, 33911, 33251, 44510, 16070, 4117, 44510, 37495, 22653, 3714, 1829, 11622, 47395, 36145, 3224, 11933, 15730, 5551, 28820, 2655, 44049, 38207, 34051, 13412, 25513, 2655, 44049, 38207, 34051, 11778, 9778, 1211, 44049, 38207, 8978, 16247, 2304, 3615, 16606, 5296, 31377, 2304, 7251, 29973, 15844, 33251, 44510, 12174, 36150, 19446, 7251, 3215, 9778, 1211, 5296, 3555, 4587, 10632, 25724, 38251, 6156, 41185, 44049, 38207, 4724, 1829, 38251, 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أدوية ثانية اللي عندهم تفوّل اللي هو الـ G6PD deficiency", "tokens": [3215, 12610, 3714, 1211, 9640, 25528, 2423, 39184, 2114, 4775, 10077, 4724, 43042, 3224, 7251, 14851, 9778, 40448, 8978, 9673, 1211, 9640, 25528, 2423, 39184, 413, 2382, 259, 4724, 43042, 3224, 7251, 14851, 9778, 40448, 8978, 5551, 29973, 46958, 9122, 12984, 48923, 9122, 7435, 11622, 38207, 36725, 3215, 2407, 10632, 38637, 7649, 10632, 9673, 27842, 45367, 7251, 10721, 9778, 8848, 11296, 2423, 39184, 460, 21, 17349, 33251, 1211, 13063, 995, 4117, 2407, 9957, 34051, 2423, 39184, 24231, 340, 12876, 339, 6746, 29826, 533, 20449, 5551, 3215, 2407, 10632, 38637, 7649, 10632, 13672, 1829, 43242, 16095, 6055, 5172, 2407, 11703, 1211, 13672, 1829, 31439, 2423, 39184, 460, 21, 17349, 37500], "avg_logprob": -0.18877840570428156, "compression_ratio": 1.660633484162896, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 2478.35, "end": 2478.73, "word": "دول", "probability": 0.26141357421875}, {"start": 2478.73, "end": 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2804.92, "end": 2805.24, "word": " الدواء", "probability": 0.8486328125}, {"start": 2805.24, "end": 2805.42, "word": " على", "probability": 0.77392578125}, {"start": 2805.42, "end": 2805.64, "word": " هذا", "probability": 0.970703125}, {"start": 2805.64, "end": 2806.06, "word": " الجين", "probability": 0.755859375}, {"start": 2806.06, "end": 2806.84, "word": " وهي", "probability": 0.5916748046875}, {"start": 2806.84, "end": 2807.22, "word": " الناحي", "probability": 0.729248046875}, {"start": 2807.22, "end": 2808.08, "word": " المهمة", "probability": 0.9977213541666666}, {"start": 2808.08, "end": 2808.96, "word": " الـ", "probability": 0.837158203125}, {"start": 2808.96, "end": 2809.64, "word": " Cytochrome", "probability": 0.766693115234375}, {"start": 2809.64, "end": 2811.84, "word": " يعني", "probability": 0.817138671875}, {"start": 2811.84, "end": 2812.64, "word": " تقريبًا", "probability": 0.9160970052083334}, {"start": 2812.64, "end": 2813.42, "word": " Cytochrome", "probability": 0.786468505859375}, {"start": 2813.42, "end": 2814.44, "word": " B450", "probability": 0.882568359375}, {"start": 2814.44, "end": 2817.9, "word": " القليل", "probability": 0.8395182291666666}, {"start": 2817.9, "end": 2818.6, "word": " استبعاته", "probability": 0.86748046875}, {"start": 2818.6, "end": 2818.82, "word": " أو", "probability": 0.984375}, {"start": 2818.82, "end": 2819.6, "word": " أنواعه", "probability": 0.939697265625}, {"start": 2819.6, "end": 2819.82, "word": " الـ", "probability": 0.7587890625}, {"start": 2819.82, "end": 2820.26, "word": " enzymes", "probability": 0.51220703125}, {"start": 2820.26, "end": 2820.66, "word": " اللي", "probability": 0.976806640625}, {"start": 2820.66, "end": 2821.18, "word": " بتدخل", "probability": 0.9716796875}, {"start": 2821.18, "end": 2821.34, "word": " في", "probability": 0.96337890625}, {"start": 2821.34, "end": 2821.54, "word": " الـ", "probability": 0.712646484375}, {"start": 2821.54, "end": 2821.74, "word": " Drug", "probability": 0.80810546875}, {"start": 2821.74, "end": 2822.52, "word": " Metabolism", "probability": 0.8854166666666666}, {"start": 2822.52, "end": 2823.74, "word": " يعني", "probability": 0.8154296875}, {"start": 2823.74, "end": 2824.52, "word": " عددها", "probability": 0.93701171875}, {"start": 2824.52, "end": 2824.8, "word": " كبير", "probability": 0.96240234375}, {"start": 2824.8, "end": 2824.94, "word": " هي", "probability": 0.77880859375}, {"start": 2824.94, "end": 2825.24, "word": " أكبر", "probability": 0.9796549479166666}, {"start": 2825.24, "end": 2825.9, "word": " مجموعة", "probability": 0.9548828125}], "temperature": 1.0}, {"id": 108, "seek": 285523, "start": 2826.41, "end": 2855.23, "text": "و تقريبًا تسعين بالمية من الأدوية تسعين بالمية من الأدوية بتتم الـ Metabolism تبعها من خلال هذا النضعف فكل ما إنسان عنده قليل معين ممكن يكون Slow أو Fast Acetylator أو Fast Metabolizer وكذا وهذه الأنواع تبعتهم ويعني المبدأ أنا مابديش أساس التفاصيل هذا Cytochrome 3A4", 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"end": 2827.05, "word": " تقريبًا", "probability": 0.8495279947916666}, {"start": 2827.05, "end": 2827.51, "word": " تسعين", "probability": 0.84112548828125}, {"start": 2827.51, "end": 2827.95, "word": " بالمية", "probability": 0.88525390625}, {"start": 2827.95, "end": 2828.19, "word": " من", "probability": 0.97705078125}, {"start": 2828.19, "end": 2828.89, "word": " الأدوية", "probability": 0.9957275390625}, {"start": 2828.89, "end": 2829.51, "word": " تسعين", "probability": 0.69451904296875}, {"start": 2829.51, "end": 2829.93, "word": " بالمية", "probability": 0.99560546875}, {"start": 2829.93, "end": 2830.13, "word": " من", "probability": 0.98779296875}, {"start": 2830.13, "end": 2830.79, "word": " الأدوية", "probability": 0.997802734375}, {"start": 2830.79, "end": 2832.31, "word": " بتتم", "probability": 0.5391845703125}, {"start": 2832.31, "end": 2832.61, "word": " الـ", "probability": 0.648193359375}, {"start": 2832.61, "end": 2833.07, "word": " Metabolism", "probability": 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"probability": 0.912841796875}, {"start": 2839.37, "end": 2839.79, "word": " يكون", "probability": 0.99267578125}, {"start": 2839.79, "end": 2840.41, "word": " Slow", "probability": 0.671875}, {"start": 2840.41, "end": 2840.71, "word": " أو", "probability": 0.9716796875}, {"start": 2840.71, "end": 2841.13, "word": " Fast", "probability": 0.91943359375}, {"start": 2841.13, "end": 2843.27, "word": " Acetylator", "probability": 0.6234130859375}, {"start": 2843.27, "end": 2843.53, "word": " أو", "probability": 0.94775390625}, {"start": 2843.53, "end": 2843.93, "word": " Fast", "probability": 0.7041015625}, {"start": 2843.93, "end": 2844.93, "word": " Metabolizer", "probability": 0.8909505208333334}, {"start": 2844.93, "end": 2845.91, "word": " وكذا", "probability": 0.8616536458333334}, {"start": 2845.91, "end": 2846.85, "word": " وهذه", "probability": 0.4737548828125}, {"start": 2846.85, "end": 2847.49, "word": " الأنواع", "probability": 0.974609375}, {"start": 2847.49, "end": 2848.33, "word": " تبعتهم", "probability": 0.8858642578125}, {"start": 2848.33, "end": 2849.77, "word": " ويعني", "probability": 0.6827799479166666}, {"start": 2849.77, "end": 2850.45, "word": " المبدأ", "probability": 0.9827473958333334}, {"start": 2850.45, "end": 2850.95, "word": " أنا", "probability": 0.72509765625}, {"start": 2850.95, "end": 2851.51, "word": " مابديش", "probability": 0.76544189453125}, {"start": 2851.51, "end": 2851.71, "word": " أساس", "probability": 0.364501953125}, {"start": 2851.71, "end": 2852.23, "word": " التفاصيل", "probability": 0.9656982421875}, {"start": 2852.23, "end": 2852.63, "word": " هذا", "probability": 0.80859375}, {"start": 2852.63, "end": 2853.71, "word": " Cytochrome", "probability": 0.867431640625}, {"start": 2853.71, "end": 2855.23, "word": " 3A4", "probability": 0.7195638020833334}], "temperature": 1.0}, {"id": 109, "seek": 288420, "start": 2855.84, "end": 2884.2, "text": "أو كروم B3A4 مثلاً، لا أريد أن يكون هذا يمكن أن واحد ينتبه عليها إنه أكثر واحد بـ 34% هذا حسب دراسة معينة في population معين في وقت معين، هكذا لك فأهمية الموضوع هذا أنه نشوف هذا الجدول اللي فوق ماشي", "tokens": [10721, 2407, 9122, 2288, 20498, 363, 18, 32, 19, 50113, 15040, 14111, 12399, 20193, 5551, 16572, 3215, 14739, 7251, 30544, 23758, 7251, 43020, 14739, 36764, 24401, 7251, 29399, 3555, 3224, 25894, 11296, 36145, 3224, 5551, 4117, 49115, 36764, 24401, 4724, 39184, 12790, 4, 23758, 11331, 35457, 11778, 23557, 3794, 3660, 20449, 9957, 3660, 8978, 4415, 20449, 9957, 8978, 4032, 38149, 20449, 9957, 12399, 8032, 4117, 15730, 5296, 4117, 6156, 10721, 16095, 10632, 9673, 2407, 11242, 45367, 23758, 14739, 3224, 8717, 8592, 38688, 23758, 25724, 3215, 12610, 13672, 1829, 6156, 30543, 3714, 33599, 1829], "avg_logprob": -0.3377659596661304, "compression_ratio": 1.6298076923076923, "no_speech_prob": 1.7881393432617188e-07, "words": [{"start": 2855.84, "end": 2856.12, "word": "أو", "probability": 0.4516143798828125}, {"start": 2856.12, "end": 2856.52, "word": " كروم", 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"probability": 0.978515625}, {"start": 2861.72, "end": 2861.94, "word": " إنه", "probability": 0.5340576171875}, {"start": 2861.94, "end": 2862.74, "word": " أكثر", "probability": 0.8102213541666666}, {"start": 2862.74, "end": 2863.12, "word": " واحد", "probability": 0.930908203125}, {"start": 2863.12, "end": 2863.4, "word": " بـ", "probability": 0.791015625}, {"start": 2863.4, "end": 2863.72, "word": " 34", "probability": 0.61279296875}, {"start": 2863.72, "end": 2864.38, "word": "%", "probability": 0.8515625}, {"start": 2864.38, "end": 2864.7, "word": " هذا", "probability": 0.74658203125}, {"start": 2864.7, "end": 2865.06, "word": " حسب", "probability": 0.945556640625}, {"start": 2865.06, "end": 2865.92, "word": " دراسة", "probability": 0.9754638671875}, {"start": 2865.92, "end": 2866.46, "word": " معينة", "probability": 0.98046875}, {"start": 2866.46, "end": 2866.58, "word": " في", "probability": 0.83544921875}, {"start": 2866.58, "end": 2867.08, "word": " population", "probability": 0.70458984375}, {"start": 2867.08, "end": 2867.82, "word": " معين", "probability": 0.978271484375}, {"start": 2867.82, "end": 2868.34, "word": " في", "probability": 0.6142578125}, {"start": 2868.34, "end": 2868.62, "word": " وقت", "probability": 0.969970703125}, {"start": 2868.62, "end": 2869.26, "word": " معين،", "probability": 0.8924153645833334}, {"start": 2869.26, "end": 2869.44, "word": " هكذا", "probability": 0.6955362955729166}, {"start": 2869.44, "end": 2869.86, "word": " لك", "probability": 0.461181640625}, {"start": 2869.86, "end": 2872.88, "word": " فأهمية", "probability": 0.83349609375}, {"start": 2872.88, "end": 2873.42, "word": " الموضوع", "probability": 0.9969482421875}, {"start": 2873.42, "end": 2873.94, "word": " هذا", "probability": 0.94482421875}, {"start": 2873.94, "end": 2877.34, "word": " أنه", "probability": 0.5321044921875}, {"start": 2877.34, "end": 2878.98, "word": " نشوف", "probability": 0.837890625}, {"start": 2878.98, "end": 2879.22, "word": " هذا", "probability": 0.912109375}, {"start": 2879.22, "end": 2879.78, "word": " الجدول", "probability": 0.9664713541666666}, {"start": 2879.78, "end": 2881.04, "word": " اللي", "probability": 0.741455078125}, {"start": 2881.04, "end": 2881.5, "word": " فوق", "probability": 0.973388671875}, {"start": 2881.5, "end": 2884.2, "word": " ماشي", "probability": 0.8525390625}], "temperature": 1.0}, {"id": 110, "seek": 291333, "start": 2888.61, "end": 2913.33, "text": "إنه الإحتمالات أحيانًا اللي نتكلم عنها هو دراسة فيه إذا الواحد بيرجع إلى المرجع تبعها اللي هو «Cytochrome B450» النوعية تبعته «2D6» هذا النوعية لما نيجي لهذا الـ «إنزايم» بالذات", "tokens": [28814, 1863, 3224, 33688, 33753, 2304, 6027, 9307, 5551, 5016, 1829, 7649, 14111, 995, 13672, 1829, 8717, 2655, 4117, 19528, 18871, 11296, 31439, 11778, 23557, 3794, 3660, 8978, 3224, 11933, 15730, 2423, 14407, 24401, 4724, 13546, 7435, 3615, 30731, 9673, 47341, 3615, 6055, 3555, 3615, 11296, 13672, 1829, 31439, 4657, 34, 4328, 8997, 11505, 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الـ affected راح يصيروا A ال test طلعهم positive و C ال test طلعهم negative واللي عندهم ماعندهم مش المرض ال test لل B طلعهم positive راح يصير هيك", "tokens": [6027, 3215, 22653, 995, 39896, 4117, 6156, 29399, 1829, 7435, 3660, 16247, 29973, 23758, 14739, 3224, 8978, 3224, 12602, 39319, 7251, 1863, 4587, 38251, 43242, 3224, 2423, 39184, 8028, 12602, 39319, 7251, 9381, 13546, 14407, 316, 2423, 1500, 23032, 1211, 3615, 16095, 3353, 4032, 383, 2423, 1500, 23032, 1211, 3615, 16095, 3671, 4032, 6027, 20292, 43242, 16095, 19446, 3615, 41260, 16095, 37893, 9673, 43042, 2423, 1500, 24976, 363, 23032, 1211, 3615, 16095, 3353, 12602, 39319, 7251, 9381, 13546, 39896, 4117], "avg_logprob": -0.19261187977261013, "compression_ratio": 1.7443181818181819, "no_speech_prob": 6.556510925292969e-07, "words": [{"start": 3879.71, "end": 3880.25, "word": "الدنيا", "probability": 0.9178466796875}, {"start": 3880.25, "end": 3880.69, "word": " هيك", "probability": 0.908935546875}, {"start": 3880.69, "end": 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الـ", "probability": 0.7666015625}, {"start": 4298.51, "end": 4298.71, "word": " N", "probability": 0.93408203125}, {"start": 4298.71, "end": 4299.51, "word": " هاي", "probability": 0.56268310546875}, {"start": 4299.51, "end": 4299.67, "word": " الـ", "probability": 0.73486328125}, {"start": 4299.67, "end": 4300.15, "word": " frequency", "probability": 0.94091796875}, {"start": 4300.15, "end": 4300.35, "word": " of", "probability": 0.77001953125}, {"start": 4300.35, "end": 4300.45, "word": " the", "probability": 0.6279296875}, {"start": 4300.45, "end": 4302.25, "word": " susceptibility", "probability": 0.84765625}, {"start": 4302.25, "end": 4303.03, "word": " الجينotype", "probability": 0.5222981770833334}, {"start": 4303.03, "end": 4303.99, "word": " نحسبها", "probability": 0.8687744140625}, {"start": 4303.99, "end": 4304.13, "word": " هي", "probability": 0.978515625}, {"start": 4304.13, "end": 4304.67, "word": " الـ", "probability": 0.801025390625}, {"start": 4304.67, "end": 4305.03, "word": " disease", "probability": 0.84521484375}, {"start": 4305.03, "end": 4305.79, "word": " prevalence", "probability": 0.95654296875}, {"start": 4305.79, "end": 4306.45, "word": " شو", "probability": 0.7054443359375}, {"start": 4306.45, "end": 4307.59, "word": " احتمالية", "probability": 0.87666015625}, {"start": 4307.59, "end": 4307.97, "word": " وجود", "probability": 0.984375}, {"start": 4307.97, "end": 4308.49, "word": " المرض", "probability": 0.99658203125}, {"start": 4308.49, "end": 4309.67, "word": " اللي", "probability": 0.95458984375}, {"start": 4309.67, "end": 4309.81, "word": " هو", "probability": 0.98681640625}, {"start": 4309.81, "end": 4310.07, "word": " A", "probability": 0.82958984375}, {"start": 4310.07, "end": 4310.39, "word": " زات", "probability": 0.41943359375}, {"start": 4310.39, "end": 4310.63, "word": " C", "probability": 0.95263671875}, {"start": 4310.63, "end": 4310.89, "word": " على", "probability": 0.89892578125}, {"start": 4310.89, "end": 4311.11, "word": " الـ", "probability": 0.919921875}, {"start": 4311.11, "end": 4311.33, "word": " N", "probability": 0.88037109375}, {"start": 4311.33, "end": 4312.75, "word": " ماشي؟", "probability": 0.8697509765625}], "temperature": 1.0}, {"id": 164, "seek": 434172, "start": 4313.33, "end": 4341.73, "text": "فيه شيء اسمه الـ Relative Risk Ratio اللي هو بالشكل هذا المعادلات هذه مهمة Disease prevalence in carriers of susceptibility genotype على Disease prevalence in non-carriers of susceptibility genotype فبتكون هذه Relative Risk Ratio بهذه الطريقة المهم كتير بنسمعها Sensitivity وSpecificity Sensitivity", "tokens": [41185, 3224, 44049, 38207, 24525, 2304, 3224, 2423, 39184, 8738, 1166, 45892, 24269, 1004, 13672, 1829, 31439, 20666, 8592, 28820, 23758, 9673, 3615, 18513, 1211, 9307, 29538, 3714, 16095, 3660, 35360, 42583, 294, 28541, 295, 26104, 2841, 1049, 13108, 15844, 35360, 42583, 294, 2107, 12, 6166, 10525, 295, 26104, 2841, 1049, 13108, 6156, 3555, 2655, 30544, 29538, 8738, 1166, 45892, 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4317.39, "word": " هو", "probability": 0.9892578125}, {"start": 4317.39, "end": 4317.89, "word": " بالشكل", "probability": 0.9796549479166666}, {"start": 4317.89, "end": 4318.29, "word": " هذا", "probability": 0.96826171875}, {"start": 4318.29, "end": 4319.27, "word": " المعادلات", "probability": 0.955859375}, {"start": 4319.27, "end": 4319.73, "word": " هذه", "probability": 0.98046875}, {"start": 4319.73, "end": 4320.49, "word": " مهمة", "probability": 0.9860026041666666}, {"start": 4320.49, "end": 4321.39, "word": " Disease", "probability": 0.5712890625}, {"start": 4321.39, "end": 4322.05, "word": " prevalence", "probability": 0.50830078125}, {"start": 4322.05, "end": 4322.51, "word": " in", "probability": 0.92236328125}, {"start": 4322.51, "end": 4323.09, "word": " carriers", "probability": 0.978515625}, {"start": 4323.09, "end": 4323.63, "word": " of", "probability": 0.92822265625}, {"start": 4323.63, "end": 4324.43, "word": " susceptibility", "probability": 0.975341796875}, {"start": 4324.43, "end": 4325.17, "word": " genotype", "probability": 0.96435546875}, {"start": 4325.17, "end": 4325.71, "word": " على", "probability": 0.6162109375}, {"start": 4325.71, "end": 4326.07, "word": " Disease", "probability": 0.379638671875}, {"start": 4326.07, "end": 4326.69, "word": " prevalence", "probability": 0.9326171875}, {"start": 4326.69, "end": 4326.95, "word": " in", "probability": 0.8076171875}, {"start": 4326.95, "end": 4327.21, "word": " non", "probability": 0.75537109375}, {"start": 4327.21, "end": 4327.73, "word": "-carriers", "probability": 0.8505859375}, {"start": 4327.73, "end": 4327.97, "word": " of", "probability": 0.82470703125}, {"start": 4327.97, "end": 4329.85, "word": " susceptibility", "probability": 0.98193359375}, {"start": 4329.85, "end": 4330.53, "word": " genotype", "probability": 0.80859375}, {"start": 4330.53, "end": 4332.03, "word": " فبتكون", "probability": 0.8275146484375}, {"start": 4332.03, "end": 4332.69, "word": " هذه", "probability": 0.369140625}, {"start": 4332.69, "end": 4333.19, "word": " Relative", "probability": 0.92919921875}, {"start": 4333.19, "end": 4333.57, "word": " Risk", "probability": 0.9169921875}, {"start": 4333.57, "end": 4334.01, "word": " Ratio", "probability": 0.9736328125}, {"start": 4334.01, "end": 4334.57, "word": " بهذه", "probability": 0.906494140625}, {"start": 4334.57, "end": 4335.15, "word": " الطريقة", "probability": 0.9930013020833334}, {"start": 4335.15, "end": 4336.97, "word": " المهم", "probability": 0.9765625}, {"start": 4336.97, "end": 4337.41, "word": " كتير", "probability": 0.84228515625}, {"start": 4337.41, "end": 4338.05, "word": " بنسمعها", "probability": 0.9310302734375}, {"start": 4338.05, "end": 4338.85, "word": " Sensitivity", "probability": 0.8180338541666666}, {"start": 4338.85, "end": 4339.85, "word": " وSpecificity", "probability": 0.87109375}, {"start": 4339.85, "end": 4341.73, "word": " Sensitivity", "probability": 0.9191080729166666}], "temperature": 1.0}, {"id": 165, "seek": 437035, "start": 4342.53, "end": 4370.35, "text": "هو قدّاش Positive من اللي عنده المرض فاللي عنده المرض A زي C اللي Test طلّعهم Positive الـ A فالـ A على الـ A زي C هي Sensitivity وSpecificity للعكس، شو نثبت أنه اللي Test طلّعهم Negative يكونوا فعلاً True Negative مش False Negative", "tokens": [3224, 2407, 12174, 3215, 11703, 33599, 46326, 9154, 13672, 1829, 43242, 3224, 9673, 43042, 6156, 6027, 20292, 43242, 3224, 9673, 43042, 316, 30767, 1829, 383, 13672, 1829, 9279, 23032, 1211, 11703, 3615, 16095, 46326, 2423, 39184, 316, 6156, 6027, 39184, 316, 15844, 2423, 39184, 316, 30767, 1829, 383, 39896, 40926, 270, 4253, 4032, 19588, 22856, 507, 24976, 3615, 4117, 3794, 12399, 13412, 2407, 8717, 12984, 3555, 2655, 14739, 3224, 13672, 1829, 9279, 23032, 1211, 11703, 3615, 16095, 43230, 7251, 30544, 14407, 6156, 3615, 15040, 14111, 13587, 43230, 37893, 50040, 43230], "avg_logprob": -0.22905219059724075, "compression_ratio": 1.696969696969697, "no_speech_prob": 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"probability": 0.31695556640625}, {"start": 4347.87, "end": 4348.25, "word": " C", "probability": 0.6201171875}, {"start": 4348.25, "end": 4350.47, "word": " اللي", "probability": 0.73974609375}, {"start": 4350.47, "end": 4351.01, "word": " Test", "probability": 0.194091796875}, {"start": 4351.01, "end": 4351.67, "word": " طلّعهم", "probability": 0.81953125}, {"start": 4351.67, "end": 4352.13, "word": " Positive", "probability": 0.83837890625}, {"start": 4352.13, "end": 4352.43, "word": " الـ", "probability": 0.6500244140625}, {"start": 4352.43, "end": 4352.67, "word": " A", "probability": 0.583984375}, {"start": 4352.67, "end": 4353.73, "word": " فالـ", "probability": 0.9661458333333334}, {"start": 4353.73, "end": 4354.09, "word": " A", "probability": 0.94677734375}, {"start": 4354.09, "end": 4354.63, "word": " على", "probability": 0.74560546875}, {"start": 4354.63, "end": 4355.11, "word": " الـ", "probability": 0.942626953125}, {"start": 4355.11, "end": 4355.35, "word": " A", "probability": 0.94482421875}, {"start": 4355.35, "end": 4355.51, "word": " زي", "probability": 0.978271484375}, {"start": 4355.51, "end": 4355.89, "word": " C", "probability": 0.958984375}, {"start": 4355.89, "end": 4356.23, "word": " هي", "probability": 0.44775390625}, {"start": 4356.23, "end": 4357.23, "word": " Sensitivity", "probability": 0.8318684895833334}, {"start": 4357.23, "end": 4359.17, "word": " وSpecificity", "probability": 0.8311767578125}, {"start": 4359.17, "end": 4360.87, "word": " للعكس،", "probability": 0.8978515625}, {"start": 4360.87, "end": 4361.05, "word": " شو", "probability": 0.764892578125}, {"start": 4361.05, "end": 4361.63, "word": " نثبت", "probability": 0.9801025390625}, {"start": 4361.63, "end": 4362.27, "word": " أنه", "probability": 0.5303955078125}, {"start": 4362.27, "end": 4363.01, "word": " اللي", "probability": 0.97998046875}, {"start": 4363.01, "end": 4364.71, "word": " Test", "probability": 0.8427734375}, {"start": 4364.71, "end": 4365.39, "word": " طلّعهم", "probability": 0.990234375}, {"start": 4365.39, "end": 4365.91, "word": " Negative", "probability": 0.9453125}, {"start": 4365.91, "end": 4366.61, "word": " يكونوا", "probability": 0.9783528645833334}, {"start": 4366.61, "end": 4367.53, "word": " فعلاً", "probability": 0.7928466796875}, {"start": 4367.53, "end": 4367.89, "word": " True", "probability": 0.82373046875}, {"start": 4367.89, "end": 4368.49, "word": " Negative", "probability": 0.95751953125}, {"start": 4368.49, "end": 4369.09, "word": " مش", "probability": 0.578125}, {"start": 4369.09, "end": 4369.89, "word": " False", "probability": 0.95263671875}, {"start": 4369.89, "end": 4370.35, "word": " Negative", "probability": 0.9462890625}], "temperature": 1.0}, {"id": 166, "seek": 440039, "start": 4371.15, "end": 4400.39, "text": "فنسبة الـ D على الـ BND اللي هو الـ Unaffected وفيه الـ Positive Predictive Value فهي معدلتها والـ Negative Predictive Value طلع عليهم، اقرؤوهم، مهم كثير وجوانب مهمة النقطة الأساسية اللي يعني اللي واحد بدي يفهمها ليه إنه الـ Sensitivity وSpecificity تناسبهم عكسي يعني", "tokens": [5172, 1863, 35457, 3660, 2423, 39184, 413, 15844, 2423, 39184, 363, 13360, 13672, 1829, 31439, 2423, 39184, 15491, 11259, 292, 4032, 41185, 3224, 2423, 39184, 46326, 430, 24945, 488, 39352, 6156, 3224, 1829, 20449, 3215, 1211, 2655, 11296, 16070, 39184, 43230, 430, 24945, 488, 39352, 23032, 1211, 3615, 25894, 16095, 12399, 1975, 4587, 2288, 33604, 2407, 16095, 12399, 3714, 16095, 9122, 12984, 13546, 49610, 2407, 7649, 3555, 3714, 16095, 3660, 28239, 47432, 3660, 16247, 3794, 32277, 10632, 13672, 1829, 37495, 22653, 13672, 1829, 36764, 24401, 4724, 16254, 7251, 5172, 16095, 11296, 32239, 3224, 36145, 3224, 2423, 39184, 40926, 270, 4253, 4032, 19588, 22856, 507, 6055, 8315, 35457, 16095, 6225, 4117, 3794, 1829, 37495, 22653], "avg_logprob": -0.18994565139646116, "compression_ratio": 1.683127572016461, "no_speech_prob": 4.172325134277344e-07, "words": [{"start": 4371.15, "end": 4372.83, "word": "فنسبة", "probability": 0.71258544921875}, {"start": 4372.83, "end": 4373.11, "word": " الـ", "probability": 0.728759765625}, {"start": 4373.11, "end": 4373.41, "word": " D", "probability": 0.384033203125}, {"start": 4373.41, "end": 4374.61, "word": " على", "probability": 0.78125}, {"start": 4374.61, "end": 4375.19, "word": " الـ", "probability": 0.94384765625}, {"start": 4375.19, "end": 4375.73, "word": " BND", "probability": 0.71826171875}, {"start": 4375.73, "end": 4376.59, "word": " اللي", "probability": 0.902587890625}, {"start": 4376.59, "end": 4376.79, "word": " هو", "probability": 0.9794921875}, {"start": 4376.79, "end": 4376.95, "word": " الـ", "probability": 0.9248046875}, {"start": 4376.95, "end": 4377.73, "word": " Unaffected", "probability": 0.798828125}, {"start": 4377.73, "end": 4378.99, "word": " وفيه", "probability": 0.8326822916666666}, {"start": 4378.99, "end": 4379.19, "word": " الـ", "probability": 0.879638671875}, {"start": 4379.19, "end": 4379.57, "word": " Positive", "probability": 0.86669921875}, {"start": 4379.57, "end": 4380.31, "word": " Predictive", "probability": 0.8255208333333334}, {"start": 4380.31, "end": 4380.81, "word": " Value", "probability": 0.96533203125}, {"start": 4380.81, "end": 4381.53, "word": " فهي", "probability": 0.6920572916666666}, {"start": 4381.53, "end": 4382.27, "word": " معدلتها", "probability": 0.98203125}, {"start": 4382.27, "end": 4382.57, "word": " والـ", "probability": 0.5338134765625}, {"start": 4382.57, "end": 4382.93, "word": " Negative", "probability": 0.95654296875}, {"start": 4382.93, "end": 4383.57, "word": " Predictive", "probability": 0.9254557291666666}, {"start": 4383.57, "end": 4383.97, "word": " Value", "probability": 0.978515625}, {"start": 4383.97, "end": 4384.87, "word": " طلع", "probability": 0.8273111979166666}, {"start": 4384.87, "end": 4385.49, "word": " عليهم،", "probability": 0.8180338541666666}, {"start": 4385.49, "end": 4386.25, "word": " اقرؤوهم،", "probability": 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"probability": 0.9469401041666666}, {"start": 4793.73, "end": 4793.89, "word": " اللي", "probability": 0.96826171875}, {"start": 4793.89, "end": 4794.01, "word": " هو", "probability": 0.99462890625}, {"start": 4794.01, "end": 4794.11, "word": " الـ", "probability": 0.87255859375}, {"start": 4794.11, "end": 4794.43, "word": " Negative", "probability": 0.7783203125}, {"start": 4794.43, "end": 4795.07, "word": " Predictive", "probability": 0.8421223958333334}, {"start": 4795.07, "end": 4795.41, "word": " Value", "probability": 0.95068359375}, {"start": 4795.41, "end": 4796.11, "word": " فهي", "probability": 0.81103515625}, {"start": 4796.11, "end": 4796.49, "word": " بتكون", "probability": 0.8544921875}, {"start": 4796.49, "end": 4796.67, "word": " هي", "probability": 0.81201171875}, {"start": 4796.67, "end": 4797.23, "word": " المهمة", "probability": 0.9977213541666666}], "temperature": 1.0}, {"id": 181, "seek": 482726, "start": 4797.88, "end": 4827.26, "text": "هذا الموضوع ممكن ندخله كمان على أكثر من جين مشترك فهنا تنظير نظري عن الـ Relative Risk لثلاث جينات مع الـ Disease Frequency فإذا فيه combination من ثلاثة الـ Relative Risk مثلاً نسبة عالية جداً، 50% من الـ Population بينما لما نكون الثلاثة Negative", "tokens": [3224, 15730, 9673, 2407, 11242, 45367, 3714, 43020, 8717, 3215, 9778, 43761, 9122, 2304, 7649, 15844, 5551, 4117, 49115, 9154, 10874, 9957, 37893, 2655, 31747, 6156, 3224, 8315, 6055, 1863, 19913, 13546, 8717, 19913, 16572, 18871, 2423, 39184, 8738, 1166, 45892, 5296, 12984, 1211, 5718, 104, 10874, 1829, 8315, 2655, 20449, 2423, 39184, 35360, 6142, 48154, 6156, 28814, 15730, 8978, 3224, 6562, 9154, 38637, 1211, 5718, 104, 3660, 2423, 39184, 8738, 1166, 45892, 50113, 15040, 14111, 8717, 35457, 3660, 6225, 6027, 10632, 10874, 28259, 14111, 12399, 2625, 4, 9154, 2423, 39184, 10215, 2776, 49374, 15042, 5296, 15042, 8717, 30544, 6024, 104, 1211, 5718, 104, 3660, 43230], "avg_logprob": -0.16355140799673917, "compression_ratio": 1.5551020408163265, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 4797.88, "end": 4798.34, "word": "هذا", "probability": 0.822509765625}, {"start": 4798.34, "end": 4798.78, "word": " الموضوع", "probability": 0.9989013671875}, {"start": 4798.78, "end": 4799.2, "word": " ممكن", "probability": 0.962158203125}, {"start": 4799.2, "end": 4799.84, "word": " ندخله", "probability": 0.887939453125}, {"start": 4799.84, "end": 4800.32, "word": " كمان", "probability": 0.9034830729166666}, {"start": 4800.32, "end": 4800.64, "word": " على", "probability": 0.90283203125}, {"start": 4800.64, "end": 4801.18, "word": " أكثر", "probability": 0.9599609375}, {"start": 4801.18, "end": 4801.62, "word": " من", "probability": 0.97607421875}, {"start": 4801.62, "end": 4803.26, "word": " جين", "probability": 0.5400390625}, {"start": 4803.26, "end": 4805.2, "word": " مشترك", "probability": 0.96484375}, {"start": 4805.2, "end": 4806.34, "word": " فهنا", "probability": 0.84716796875}, {"start": 4806.34, "end": 4808.18, 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"word": " فإذا", "probability": 0.88818359375}, {"start": 4817.82, "end": 4818.1, "word": " فيه", "probability": 0.71875}, {"start": 4818.1, "end": 4818.6, "word": " combination", "probability": 0.346923828125}, {"start": 4818.6, "end": 4818.88, "word": " من", "probability": 0.99609375}, {"start": 4818.88, "end": 4819.68, "word": " ثلاثة", "probability": 0.95546875}, {"start": 4819.68, "end": 4820.22, "word": " الـ", "probability": 0.876220703125}, {"start": 4820.22, "end": 4820.62, "word": " Relative", "probability": 0.973876953125}, {"start": 4820.62, "end": 4821.08, "word": " Risk", "probability": 0.9306640625}, {"start": 4821.08, "end": 4821.88, "word": " مثلاً", "probability": 0.7198893229166666}, {"start": 4821.88, "end": 4822.4, "word": " نسبة", "probability": 0.9225260416666666}, {"start": 4822.4, "end": 4822.76, "word": " عالية", "probability": 0.9832356770833334}, {"start": 4822.76, "end": 4823.24, "word": " جداً،", "probability": 0.8148193359375}, {"start": 4823.24, "end": 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بدي أفرقها بين أهمية الفحص كـ Screening لـ Population و لـ Diagnostic Test هون أحطي مثال اللي هو الأبو شيء معين بدرسوه في حالة الـ Alzheimer", "tokens": [6027, 39184, 8738, 1166, 3148, 307, 588, 12, 448, 5336, 13672, 1829, 39896, 1958, 13, 13328, 4, 37495, 22653, 16490, 2304, 3794, 3660, 20666, 10721, 46538, 27188, 4117, 25720, 50113, 15040, 12399, 41850, 4724, 26108, 1829, 37495, 22653, 32239, 3224, 4724, 16254, 5551, 5172, 2288, 4587, 11296, 49374, 5551, 16095, 10632, 27188, 5016, 9381, 9122, 39184, 25823, 278, 5296, 39184, 10215, 2776, 4032, 5296, 39184, 8789, 4535, 19634, 9279, 8032, 11536, 5551, 5016, 9566, 1829, 50113, 6027, 13672, 1829, 31439, 16247, 3555, 2407, 44049, 38207, 20449, 9957, 47525, 2288, 3794, 2407, 3224, 8978, 11331, 6027, 3660, 2423, 39184, 27932], "avg_logprob": -0.2656249925494194, "compression_ratio": 1.4246031746031746, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 4827.92, "end": 4828.18, "word": "الـ", "probability": 0.2886962890625}, 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4833.3, "end": 4833.74, "word": " خمسة", "probability": 0.826416015625}, {"start": 4833.74, "end": 4834.18, "word": " بالألف", "probability": 0.9329427083333334}, {"start": 4834.18, "end": 4836.94, "word": " الفكرة", "probability": 0.9671223958333334}, {"start": 4836.94, "end": 4839.46, "word": " مثلا،", "probability": 0.68115234375}, {"start": 4839.46, "end": 4839.72, "word": " أنا", "probability": 0.93798828125}, {"start": 4839.72, "end": 4840.44, "word": " باجي", "probability": 0.9093424479166666}, {"start": 4840.44, "end": 4841.58, "word": " يعني", "probability": 0.953369140625}, {"start": 4841.58, "end": 4841.82, "word": " ليه", "probability": 0.962646484375}, {"start": 4841.82, "end": 4842.04, "word": " بدي", "probability": 0.6517333984375}, {"start": 4842.04, "end": 4842.68, "word": " أفرقها", "probability": 0.96328125}, {"start": 4842.68, "end": 4843.08, "word": " بين", "probability": 0.96240234375}, {"start": 4843.08, "end": 4843.64, "word": " أهمية", "probability": 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أنا أستخدمه إذا بروح أعمل فيه Population Screening يعني باجي عن جنب وطرف كل اللي أعمارهم من 65 إلى 74 سنة باجي بفحصهم إذا كان الـ Prevalence للـ Population للـ Alzheimer Disease 3%", "tokens": [5172, 10721, 8315, 12399, 37495, 22653, 41850, 18871, 16254, 23758, 2423, 39184, 9279, 4032, 3215, 9778, 1211, 8315, 3224, 8978, 32771, 11622, 3660, 46599, 14851, 9566, 40228, 36145, 41850, 5551, 14851, 9778, 40448, 3224, 11933, 15730, 4724, 32887, 5016, 5551, 25957, 1211, 8978, 3224, 10215, 2776, 25823, 278, 37495, 22653, 4724, 26108, 1829, 18871, 10874, 1863, 3555, 4032, 9566, 28480, 28242, 13672, 1829, 5551, 25957, 9640, 16095, 9154, 11624, 30731, 28868, 8608, 1863, 3660, 4724, 26108, 1829, 4724, 5172, 5016, 9381, 16095, 11933, 15730, 25961, 2423, 39184, 6001, 3337, 655, 24976, 39184, 10215, 2776, 24976, 39184, 27932, 35360, 805, 4], "avg_logprob": -0.1870358934496889, "compression_ratio": 1.4879032258064515, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 4856.86, "end": 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"word": " كان", "probability": 0.99853515625}, {"start": 4877.6, "end": 4878.18, "word": " الـ", "probability": 0.97607421875}, {"start": 4878.18, "end": 4879.3, "word": " Prevalence", "probability": 0.9026692708333334}, {"start": 4879.3, "end": 4879.58, "word": " للـ", "probability": 0.64404296875}, {"start": 4879.58, "end": 4880.28, "word": " Population", "probability": 0.885986328125}, {"start": 4880.28, "end": 4880.68, "word": " للـ", "probability": 0.78173828125}, {"start": 4880.68, "end": 4881.34, "word": " Alzheimer", "probability": 0.96826171875}, {"start": 4881.34, "end": 4882.5, "word": " Disease", "probability": 0.72607421875}, {"start": 4882.5, "end": 4883.24, "word": " 3", "probability": 0.438720703125}, {"start": 4883.24, "end": 4883.94, "word": "%", "probability": 0.90380859375}], "temperature": 1.0}, {"id": 184, "seek": 490364, "start": 4885.55, "end": 4903.65, "text": "النتيجة أن قيمة الفحص سيئة لدي لأن المرض ليس متواجدًا وغالبًا اللي سيصبح Positive الـ Positive Predictive Value ستكون 6% وإذا كان شيء آخر 23%، فهو نسبة قليلة", "tokens": [6027, 29399, 1829, 7435, 3660, 14739, 12174, 32640, 3660, 27188, 5016, 9381, 8608, 1829, 19986, 3660, 5296, 16254, 5296, 33456, 9673, 43042, 32239, 3794, 44650, 2407, 26108, 3215, 14111, 995, 4032, 17082, 6027, 3555, 14111, 995, 13672, 1829, 8608, 1829, 9381, 49628, 46326, 2423, 39184, 46326, 430, 24945, 488, 39352, 8608, 2655, 30544, 1386, 4, 4032, 28814, 15730, 25961, 44049, 38207, 19753, 34740, 6673, 4, 12399, 6156, 3224, 2407, 8717, 35457, 3660, 12174, 20292, 37977], "avg_logprob": -0.3661595284938812, "compression_ratio": 1.3494623655913978, "no_speech_prob": 2.384185791015625e-07, "words": [{"start": 4885.55, "end": 4886.51, "word": "النتيجة", "probability": 0.920703125}, {"start": 4886.51, "end": 4886.99, "word": " أن", "probability": 0.49267578125}, {"start": 4886.99, "end": 4888.13, "word": " قيمة", "probability": 0.953125}, {"start": 4888.13, "end": 4888.53, "word": " الفحص", "probability": 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{"start": 4920.39, "end": 4920.79, "word": " أنا", "probability": 0.6845703125}, {"start": 4920.79, "end": 4922.21, "word": " أعمله", "probability": 0.9747721354166666}, {"start": 4922.21, "end": 4922.87, "word": " إشي", "probability": 0.9894205729166666}, {"start": 4922.87, "end": 4923.59, "word": " وأفيده", "probability": 0.824609375}, {"start": 4923.59, "end": 4924.85, "word": " طبعا", "probability": 0.913330078125}, {"start": 4924.85, "end": 4925.45, "word": " الـ", "probability": 0.796875}, {"start": 4925.45, "end": 4926.41, "word": " False", "probability": 0.276611328125}, {"start": 4926.41, "end": 4927.37, "word": " Positive", "probability": 0.69677734375}, {"start": 4927.37, "end": 4927.85, "word": " اللي", "probability": 0.94287109375}, {"start": 4927.85, "end": 4928.37, "word": " ماعندوش", "probability": 0.8615234375}, {"start": 4928.37, "end": 4928.75, "word": " مرض", "probability": 0.993896484375}, {"start": 4928.75, "end": 4929.25, "word": " وطلعت", "probability": 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5075.8, "end": 5094.6, "text": "فالفكرة هنا لو أنا استخدمته في الـ population اللي كويسة المجموع اللي كويسة أروح أعمل هذا الفحص كـ Diagnostic Test راح يكون أنا بصير والله يعجبني أكثر الموضوع إذا طلع Negative", "tokens": [5172, 6027, 5172, 4117, 25720, 34105, 45164, 41850, 44713, 9778, 40448, 47395, 8978, 2423, 39184, 4415, 13672, 1829, 9122, 45865, 3794, 3660, 9673, 7435, 2304, 45367, 13672, 1829, 9122, 45865, 3794, 3660, 5551, 32887, 5016, 5551, 25957, 1211, 23758, 27188, 5016, 9381, 9122, 39184, 8789, 4535, 19634, 9279, 12602, 39319, 7251, 30544, 41850, 4724, 9381, 13546, 16070, 43761, 37495, 7435, 3555, 22653, 5551, 4117, 49115, 9673, 2407, 11242, 45367, 11933, 15730, 23032, 1211, 3615, 43230], "avg_logprob": -0.16313733434990832, "compression_ratio": 1.4922279792746114, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 5075.8, "end": 5077.18, "word": "فالفكرة", "probability": 0.8720703125}, {"start": 5077.18, "end": 5078.58, "word": " هنا", "probability": 0.74609375}, 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\ No newline at end of file
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/hUu77dlYhF8_raw.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/hUu77dlYhF8_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..1ca23d47dd135a8c9fbaa9f55649085c07ce8656
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/hUu77dlYhF8_raw.srt
@@ -0,0 +1,3789 @@
+1
+00:00:06,510 --> 00:00:13,430
+بسم الله الرحمن الرحيم أهياركم الله ونبدأ إن شاء
+
+2
+00:00:13,430 --> 00:00:18,950
+الله المحاضرة فبنبدأ نسأل في أي حد عنده استفسار عن
+
+3
+00:00:18,950 --> 00:00:27,230
+النقاط اللي قبل؟ في أي أسئلة؟ في أي شيء؟ إحنا إن
+
+4
+00:00:27,230 --> 00:00:33,570
+شاء الله يوم الجمعة هيكون chapters تمانية وتسعة أو
+
+5
+00:00:33,570 --> 00:00:38,990
+عشرة أو أحداشرأنا مش ذاكر فصل تمانية دخلناها بالـ
+
+6
+00:00:38,990 --> 00:00:43,210
+mid-term quiz يا دكتور أحمد و اللي ما دي كانش داخل
+
+7
+00:00:43,210 --> 00:00:47,870
+طنيت أنه دقلناها صحيح هو أيام حطيت عليه أكتر من
+
+8
+00:00:47,870 --> 00:00:51,850
+سؤال انت قلتلي لسه ما .. يعني ما .. بحكي .. السؤال
+
+9
+00:00:51,850 --> 00:00:57,050
+الأسئلة ما شملتش كل ال chapter طيب طيب إن شاء الله
+
+10
+00:00:57,050 --> 00:01:01,410
+فعشان هيك أنا قلت إذا كان في أسئلة أنت حابب تضيف
+
+11
+00:01:01,410 --> 00:01:06,370
+أو حاجة عشان ذلكإذا في حد عنده أسئلة صراحة المراجع
+
+12
+00:01:06,370 --> 00:01:10,670
+أو المراجع كلها إحنا إن شاء الله الأسبوع هذا راح
+
+13
+00:01:10,670 --> 00:01:15,850
+نخلص الكتاب بالناحية الفصول اللي فيها مواضيع أما
+
+14
+00:01:15,850 --> 00:01:22,090
+بيظل جوانب العلم بالنسبة لتفاصيل الأمراض هذه
+
+15
+00:01:22,090 --> 00:01:27,550
+مستحيل تطلب اليوم أو تكون هيك يعني بالتفاصيل
+
+16
+00:01:27,550 --> 00:01:33,940
+المطلوبة بقدرلأن هذه بتكون يعني بدّوا الواحد سنين
+
+17
+00:01:33,940 --> 00:01:37,800
+وبدّوا الواحد خبرة وبدّوا الواحد يكون شاف الحالات
+
+18
+00:01:37,800 --> 00:01:42,360
+يعني حتى يستوعبها تماماً في أشياء موجودة عندنا وهي
+
+19
+00:01:42,360 --> 00:01:46,580
+لازم الواحد يركز عليها بس في أحيانا مبادئ في
+
+20
+00:01:46,580 --> 00:01:49,040
+الوراثة
+
+21
+00:01:49,600 --> 00:01:56,720
+بتلاقيها موضّحة أكثر بأمثلة في مجموعات
+
+22
+00:01:56,720 --> 00:02:00,620
+بشرية أخرى يعني مش ضروري علنا يعني بس يمكن الواحد
+
+23
+00:02:00,620 --> 00:02:09,780
+مهم أنه يشوفها عشان يعني موضوع أنه يكون يعني يطلع
+
+24
+00:02:09,780 --> 00:02:16,120
+على المفهوم الطبي العلمي الوراثي اليوم احنا راح
+
+25
+00:02:16,120 --> 00:02:22,490
+ناخد الفصل 18وإن شاء الله نهاية اليوم الأربعة ندخل
+
+26
+00:02:22,490 --> 00:02:26,870
+آخر موضوع وموضوع مهم جداً أخلاقيات الوراتة،
+
+27
+00:02:26,870 --> 00:02:31,010
+أخلاقيات التعامل مع هذه الأمراض وهذه الحالات وهذه
+
+28
+00:02:31,010 --> 00:02:36,950
+الإمكانات، وصراحة موضوع مهم اليوم راح نتكلم على
+
+29
+00:02:38,520 --> 00:02:41,400
+«personalized healthcare» أو «personalized
+
+30
+00:02:41,400 --> 00:02:50,780
+medicine» يعني الطب الفردي، الطب الشخصي أحنا يعني،
+
+31
+00:02:50,780 --> 00:02:57,760
+وهذا لبعض التطبيقات للـGenomics والـGenetics في
+
+32
+00:02:57,760 --> 00:03:05,080
+الـ«personalized healthcare» فيعني هو موضوع بصراحة
+
+33
+00:03:05,660 --> 00:03:12,220
+ممتع ويعني حتى أنا بقول بالنسبة للأردن في جانب منه
+
+34
+00:03:12,220 --> 00:03:18,020
+مطبق بس في جوانب كثيرة غير مطبقة أو لا نستطيع
+
+35
+00:03:18,020 --> 00:03:22,360
+القيام فيها بالشكل اللي الدول اللي عندها إمكانات
+
+36
+00:03:22,360 --> 00:03:27,480
+متقدمة وعندها نظم صحية بتهتم بصحة الفرد حيث كل
+
+37
+00:03:27,480 --> 00:03:33,280
+إنسان يحاولوا أنه يخلوه بأعلى درجة من الصحة الـ
+
+38
+00:03:35,700 --> 00:03:43,280
+الفكرة أنه بالنسبة للـ Personalized Medicine إنه
+
+39
+00:03:43,280 --> 00:03:48,080
+إذا في إمكانية بالإضافة للتاريخ العائلي للـ
+
+40
+00:03:48,080 --> 00:03:51,980
+History Taking والـ Family History والجوانب الأخرى
+
+41
+00:03:51,980 --> 00:03:59,750
+السريرية من كيف نأخذ تاريخ مرض من المريضإذا الواحد
+
+42
+00:03:59,750 --> 00:04:06,830
+عنده يعني خصوصاً إذا بتثبتها دراسات من قبل ممكن
+
+43
+00:04:06,830 --> 00:04:11,050
+الواحد يتلافى كثير من المشاكل زي ما بيقولوا دايماً
+
+44
+00:04:11,050 --> 00:04:16,510
+الوقاية خير من العلاج أو قنطة يعني درهم وقاية خير
+
+45
+00:04:16,510 --> 00:04:21,810
+من قطار علاج فمن الأمثلة على الأشياء المهمة
+
+46
+00:04:21,810 --> 00:04:27,570
+والقوية بهذا الموضوعمثلًا، ناخد حالة وهي للأسف
+
+47
+00:04:27,570 --> 00:04:33,630
+الأمثلة على الكثير من الأشياء والمفاهيم هذه ما
+
+48
+00:04:33,630 --> 00:04:39,350
+بتتوضح إلا من خلال مثال «بد الواحد يكون احتك بمريد
+
+49
+00:04:39,350 --> 00:04:44,430
+من هذا النوع حتى يعرف همية هذا الموضوع» فعندنا
+
+50
+00:04:44,430 --> 00:04:48,070
+مثلًا اللي هو الـ Colon Cancer «سرطان القلون»
+
+51
+00:04:48,070 --> 00:04:54,440
+«سرطان الأمعاء الغليظة»مرض؟ والله في مستشفانة
+
+52
+00:04:54,440 --> 00:04:59,440
+ومركز تحويلي ثالثي يعني مستشفى الجامعي إن حالات
+
+53
+00:04:59,440 --> 00:05:05,580
+كثيرة، بالأردن تيجي حالات كثيرة الفكرة في الموضوع
+
+54
+00:05:05,580 --> 00:05:17,960
+هذا إنه لما نحن نشوف مثل هذه النقطة إنه إذا
+
+55
+00:05:17,960 --> 00:05:23,270
+الإنسان يعني وكان عنده علمإنه على عمر الخمس
+
+56
+00:05:23,270 --> 00:05:31,570
+وثلاثين إذا الإنسان صاب سرطان قلون فهذا يضاعف
+
+57
+00:05:31,570 --> 00:05:38,470
+درجات مضاعفة كثيرة نسبة احتمالية إن الأفراد
+
+58
+00:05:38,470 --> 00:05:42,990
+العائلة للآخرين مصابين بسرطان القلون أو يصابوا
+
+59
+00:05:42,990 --> 00:05:50,770
+بسرطان القلون فهنا بيفرجونا دراسةأو نتيجة دراسة
+
+60
+00:05:50,770 --> 00:06:00,190
+معينة محددة بيفرجيكم الفرق بين نسبة
+
+61
+00:06:00,190 --> 00:06:05,170
+سرطان القلون في اللي عندهم تاريخ مرض عائلي بالنسبة
+
+62
+00:06:05,170 --> 00:06:10,630
+لهذا المرض وبين اللي ما عندهم مش بدرجات كبيرة بس
+
+63
+00:06:10,630 --> 00:06:15,370
+الفكرة إنه يكون السرطان قبل عمره الخمس وثلاثين
+
+64
+00:06:15,370 --> 00:06:24,770
+إحنا في الطب عامةًبنتكلم على إنه هناك يفضل إن يكون
+
+65
+00:06:24,770 --> 00:06:33,330
+بعض البرامج للبحث عن السرطان حسب العمر، حسب
+
+66
+00:06:33,330 --> 00:06:38,950
+الحالة، حسب النوعية، حسب المجموعة البشرية الـ
+
+67
+00:06:38,950 --> 00:06:45,090
+Population اللي عندنا إياها فهذه دايماً جانب لازم
+
+68
+00:06:45,090 --> 00:06:50,530
+الواحد يهتم فيهفإذا كان يعني عادةً إحنا سلطان
+
+69
+00:06:50,530 --> 00:06:55,290
+القلون نقعد إنه بنسوي Screening عليه مرات إذا
+
+70
+00:06:55,290 --> 00:06:59,370
+بيعملوها فإنه أنا شخصياً يعني في مستشفانة وأنا لست
+
+71
+00:06:59,370 --> 00:07:04,910
+وخصائي أو رام مابنعملهاش بشكل كما هو مطلوب على سن
+
+72
+00:07:04,910 --> 00:07:09,490
+الأربعين أو الخمسين المفروض الإنسان يعني هيك اللي
+
+73
+00:07:09,490 --> 00:07:14,170
+بيقولوه يعني المفروض الإنسان أولاً يعمل فحص وراز
+
+74
+00:07:14,170 --> 00:07:18,880
+للدم الخفيوهذا بيبين إن هناك نوع من النزف أو الـ
+
+75
+00:07:18,880 --> 00:07:23,640
+«شيء» هذا بيكون إيجابي أكثر في اللي عندهم سرطان
+
+76
+00:07:23,640 --> 00:07:30,920
+قولون مفروض على سن الخمس وخمسين أو حسب الحالة ممكن
+
+77
+00:07:30,920 --> 00:07:36,860
+إنه يعمل قولون يعني أبارعاً تنظير لمعاء السفلية
+
+78
+00:07:36,860 --> 00:07:47,200
+فحص بغلب، بده تجهيز، بس بيقولوا إنه لازم ينعملفمن
+
+79
+00:07:47,200 --> 00:07:51,500
+أهم المجموعات اللي احنا لازم نركز على هذا الموضوع
+
+80
+00:07:51,500 --> 00:07:59,600
+لأنه صراحة أي مشكلة، يعني أنا بضرب مثال المرضة
+
+81
+00:07:59,600 --> 00:08:03,500
+في مرض اسمه «Alterative Colitis» اللي هو التهاب
+
+82
+00:08:03,500 --> 00:08:09,300
+القلون التقرحي نسبة عالية جدا بعد عشر سنوات من
+
+83
+00:08:09,300 --> 00:08:13,940
+أصابتهم بهذا المرض يصابوا بمضاعفات اللي يصبح لديهم
+
+84
+00:08:13,940 --> 00:08:21,270
+سلطان في القلونبعض الأشياء التي حتى قبل أن تصبح
+
+85
+00:08:21,270 --> 00:08:25,970
+مضاعفات أخرى غير هذا الموضوع بس أهم شيء لخطر
+
+86
+00:08:25,970 --> 00:08:31,450
+السرطان ينصح بإزالة القلون بأكمله يعني الواحد يعيش
+
+87
+00:08:31,450 --> 00:08:36,730
+من غير قلون، يعني حياته غلبهويكون عنده Divergent
+
+88
+00:08:36,730 --> 00:08:41,930
+Colostomy ويكون عنده فتحة جانبية للإخراج وكذا يعني
+
+89
+00:08:41,930 --> 00:08:47,430
+مش منظر ولا عيشة بس أحسن من الوفاة بالسلطان، سلطان
+
+90
+00:08:47,430 --> 00:08:54,710
+القلون فهناك نقاط كثيرة، بس الفكرة إنه إذا أنا
+
+91
+00:08:54,710 --> 00:08:59,530
+أتعامل مع إنسان لديه قريب من الدرجة الأولى عنده
+
+92
+00:08:59,530 --> 00:09:05,470
+سلطان القلون، أنا يجب أن يعنيأنتبه لهذا الجانب
+
+93
+00:09:05,470 --> 00:09:11,770
+وأدور عليه بحيث أنه ألقط السلطان هو لسه في المرحلة
+
+94
+00:09:11,770 --> 00:09:16,610
+الأولى وإذا بحتاج أشيل نص القلون أو ربع القلون أو
+
+95
+00:09:16,610 --> 00:09:22,850
+كل القلون بشيله يعني بعيش المريض ويكون الأمر أفضل
+
+96
+00:09:22,850 --> 00:09:28,200
+فهذا يعني جانبلو أنا انتبهت إلها في تاريخ المرض
+
+97
+00:09:28,200 --> 00:09:32,460
+يتبع مريضي كان أنا يجب أن أتعامل معاه بشكل مختلف
+
+98
+00:09:32,460 --> 00:09:39,360
+بدي أتعامل معاه بطريقة أخرى فبالنسبة
+
+99
+00:09:39,360 --> 00:09:43,900
+للموضوع الثاني فهذا مثال على Personalized Medicine
+
+100
+00:09:43,900 --> 00:09:47,840
+أنا لو أجاني إنسان طبيعي عادي ماعنده أي تاريخ مرضي
+
+101
+00:09:47,840 --> 00:09:52,440
+لـ سلطان القلونالمفروض أنه يعملوا بشكل مختلف، بس
+
+102
+00:09:52,440 --> 00:09:57,220
+لو كان عنده هذه المشكلة
+بتكون لها ناحية مهمة
+
+103
+00:09:57,220 --> 00:10:05,900
+المبدأ الثاني اللي بتكلم عليه الفصل هذا بمحاولة
+
+104
+00:10:05,900 --> 00:10:13,360
+التفريد وجعل الطبمناسب لكل فرد بحد ذاته حسب تاريخه
+
+105
+00:10:13,360 --> 00:10:19,240
+العائلي ووراثته وجوانب في حياته أو في الوراثة
+
+106
+00:10:19,240 --> 00:10:26,320
+تبعته إنه أنا أدور على الأمراض حتى يعني على فترة
+
+107
+00:10:26,320 --> 00:10:36,000
+على عمر صغير ومن أولها من مرحلة الولادة يعني في
+
+108
+00:10:36,000 --> 00:10:40,770
+الولايات المتحدة الأمريكية وهذا الجدول منههناك
+
+109
+00:10:40,770 --> 00:10:47,630
+مجموعة من الأمراض يعني إلها حظ وافر من نسبة إنه
+
+110
+00:10:47,630 --> 00:10:55,030
+يكون الإنسان يولد فيها فمنها الحطي رقم واحد الـ
+
+111
+00:10:55,030 --> 00:10:59,190
+Conjugate اللي هي Hearing Loss طبعاً هنا حاطينه
+
+112
+00:10:59,190 --> 00:11:06,220
+200 حالة لكل 100 ألف مولود جديدفهي نسبة تعتبر يعني
+
+113
+00:11:06,220 --> 00:11:11,100
+عالية، المفروض الواحد يفكر فيها ويدور عليها وكذا،
+
+114
+00:11:11,100 --> 00:11:16,140
+اللي راح ناخد بعد شوية ليش أو كيف احنا بندور، وشو
+
+115
+00:11:16,140 --> 00:11:21,840
+بنستخدمه كمحددات لأهمية هذا الجانب، بعدين فيه
+
+116
+00:11:21,840 --> 00:11:27,060
+Sickle Cell Disease، مرض الأنيميا المنجلية، هبوط
+
+117
+00:11:27,060 --> 00:11:32,890
+وظيفة الغد الدراقية،مرض عندي بتعامل معاه كثير الـ
+
+118
+00:11:32,890 --> 00:11:38,090
+Phenylketonuria في أشياء ثانية برضه Severe
+
+119
+00:11:38,090 --> 00:11:43,010
+congenital adrenal hyperplasia أو Severe combined
+
+120
+00:11:43,010 --> 00:11:46,730
+immune deficiency كالكتوسيميا أنا أظن Mabel's
+
+121
+00:11:46,730 --> 00:11:52,590
+syrup disease، Homocystinuria وكذا أنا يعني أظن
+
+122
+00:11:52,590 --> 00:11:58,540
+الآنبالذات الأمراض النادرة وفي بيئة أو في مجموعة
+
+123
+00:11:58,540 --> 00:12:02,360
+بشرية مش عندنا، مش في population تبعتنا، ما
+
+124
+00:12:02,360 --> 00:12:07,120
+بيهمنيش كثير، بس Sickle Cell Disease متواجد،
+
+125
+00:12:07,120 --> 00:12:10,360
+الـHypothyroidism ممكن، الـPhenylketonuria أنا
+
+126
+00:12:10,360 --> 00:12:16,340
+متأكد عندنا، البقية حاطين عندهم كمية قليلة، وطبعاً
+
+127
+00:12:16,340 --> 00:12:21,160
+جزء من الموضوع يتبع فهم الواحد لنوع الـInheritance
+
+128
+00:12:21,160 --> 00:12:22,300
+تبع هذا الـDisease
+
+129
+00:12:25,810 --> 00:12:34,610
+هذه الأمراض بتهمنا من ناحية بتهمنا من ناحية إنها
+
+130
+00:12:34,610 --> 00:12:37,770
+أول شيء طبعاً لازم تكون الأشياء اللي موجودة عندنا
+
+131
+00:12:37,770 --> 00:12:41,670
+يعني ما بهمني مرض أنا مش موجود في الـ population
+
+132
+00:12:41,670 --> 00:12:48,290
+تبعتي، هذه من ناحية وهنا نتكلم على Newborn
+
+133
+00:12:48,290 --> 00:12:55,380
+Screening Program برنامج المسح للموليد الجددهذا
+
+134
+00:12:55,380 --> 00:12:58,840
+برنامج اتطرقت إليه من قبل إنه إحنا بنطبقينه في
+
+135
+00:12:58,840 --> 00:13:02,260
+القردن الله يرضى عليها الدكتورة سناسق في الحيط قبل
+
+136
+00:13:02,260 --> 00:13:09,160
+مدة يعني كافحت في وزارة الصحة حتى تخلي البرنامج
+
+137
+00:13:09,160 --> 00:13:15,720
+هذا موجود وشو الجوانب اللي يعني بندور عليها وكيف
+
+138
+00:13:15,720 --> 00:13:24,710
+بندور عليها فهي بشكل أساسيزي في غزة وفلسطين إنه كل
+
+139
+00:13:24,710 --> 00:13:29,350
+مولود على الأسبوع الأول على عمر الأسبوع على
+
+140
+00:13:29,350 --> 00:13:33,950
+الولادة الطبيعية لما يروح البيت بيأتي بعد أسبوع
+
+141
+00:13:33,950 --> 00:13:38,070
+بيأخذ المطعم الأول هيك تقريبًا يعني لأنه في
+
+142
+00:13:38,070 --> 00:13:46,350
+متابعات محددة للمولود الجديد فمنها بيأخذ نقطة دم
+
+143
+00:13:46,350 --> 00:13:52,030
+من كعب الطفلفهي شغل يعني بيكون جاي يأخذ المطعم
+
+144
+00:13:52,030 --> 00:13:58,230
+أهله جاي بينه وبنأخذ على ورقة نشاف بحطه نقطة دم
+
+145
+00:13:58,230 --> 00:14:05,030
+واحدة وبيبعثوها للمختبر يعني هي بتنشف وتترك وبعدين
+
+146
+00:14:05,030 --> 00:14:10,970
+كل أسبوع كل مدة بيلموا اللي موجود هذا وفيه فحص راح
+
+147
+00:14:10,970 --> 00:14:18,690
+نحكي عنه فحص سريع لأشياء كثيرة وبيعملوا الفحصيعني
+
+148
+00:14:18,690 --> 00:14:26,890
+ليش يعمل أو لأي أمراض يعمل لازم يكون فيها محددات
+
+149
+00:14:26,890 --> 00:14:36,970
+مهمة أولاً اللي هي سمنها يعني القدرة التحليلية أو
+
+150
+00:14:36,970 --> 00:14:42,050
+الفائدة التحليلية لهذا الفحص فالمفروض يكون زي ما
+
+151
+00:14:42,050 --> 00:14:45,670
+كاتبين قدامكم في هذا الـBox مهم كثير لشروط
+
+152
+00:14:45,670 --> 00:14:49,670
+الـScreening Program«محاولة عمل محاولة عمل عمل عمل
+
+153
+00:14:49,670 --> 00:14:50,710
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+154
+00:14:50,710 --> 00:14:53,230
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+155
+00:14:53,230 --> 00:14:53,590
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+156
+00:14:53,590 --> 00:14:53,610
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+157
+00:14:53,610 --> 00:14:54,150
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+158
+00:14:54,150 --> 00:14:56,990
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+159
+00:14:56,990 --> 00:14:57,010
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+160
+00:14:57,010 --> 00:15:03,910
+عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل
+
+161
+00:15:03,910 --> 00:15:11,390
+عمل عمل عمل عمل عمل
+
+162
+00:15:11,390 --> 00:15:16,430
+عمل
+
+163
+00:15:16,430 --> 00:15:23,550
+عفالـ Hypothyroidism الشغل على الـ TSH مثلا أو
+
+164
+00:15:23,550 --> 00:15:30,390
+اللي هو الـ T3 و T4 بس أضل من الـ TSH إذا كان
+
+165
+00:15:30,390 --> 00:15:34,610
+مرتفع معناته فيه Hypothyroidism الفناع الأنالين
+
+166
+00:15:34,610 --> 00:15:38,230
+اللي بيطلع ويكون مرتفع في الفناع الكيتونيوريا
+
+167
+00:15:38,230 --> 00:15:45,430
+بيكون يعني مرتفع في اللي عندهم المتابولات هذا في
+
+168
+00:15:45,430 --> 00:15:51,810
+اللي عندهم هذا المرضفالفكرة أنه لازم يكون عندي فحص
+
+169
+00:15:51,810 --> 00:16:00,010
+simple وسريع يعني ما بده شغل كثير وبعدين إمكانية
+
+170
+00:16:00,010 --> 00:16:05,830
+عمله رخيص مابدنا إشي مكلف الصراحة مثلا، أنا اللي
+
+171
+00:16:05,830 --> 00:16:12,110
+بيجننني مثلا، إن شاء الله فاهمين عليا بيجننني مثلا
+
+172
+00:16:12,110 --> 00:16:16,560
+بلد زي أمريكا مع مرض زي الـ COVIDوحتى في الأردن
+
+173
+00:16:16,560 --> 00:16:21,060
+وكذا، يعني هنا في الأردن الـ يعني بتتكلم على
+
+174
+00:16:21,060 --> 00:16:26,660
+بالمتوسط أو تقريبًا فحص الـ COVID 50، 30 دينار،
+
+175
+00:16:26,660 --> 00:16:31,880
+هيك تقريبًا سعره 30 دينار يعني، ماعرفش كيف تحسبوها
+
+176
+00:16:31,880 --> 00:16:38,380
+يعني بتطلع حوالي على point seven يعني تقريبًا
+
+177
+00:16:38,380 --> 00:16:46,140
+خمسين دولار، خمس واربعين دولار، ماشيفيجي الواحد
+
+178
+00:16:46,140 --> 00:16:50,240
+مثلًا في بلد زي أمريكا يقول في بعض الناس بيدعو إنه
+
+179
+00:16:50,240 --> 00:16:56,040
+نفحص كل البشر أو نفحص عدد كبير طب ما أنت كل إنسان
+
+180
+00:16:56,040 --> 00:17:01,620
+بـ 30، 40 دولار لكل بني آدم، هاي صارنا بالمليارات،
+
+181
+00:17:01,620 --> 00:17:07,420
+إذا ما إلها قيمة وما إلها فايدة وما إلها مية، راح
+
+182
+00:17:07,420 --> 00:17:16,460
+تكون يعني .. يعني ..هدر كامل أو هدر كبير من
+
+183
+00:17:16,460 --> 00:17:24,380
+الإمكانات اللي كان ممكن تتوجه لشيء مفيد الموضوع
+
+184
+00:17:24,380 --> 00:17:28,860
+الثاني يعني الأهمية الثانية للـلإيش نختار ونحط في
+
+185
+00:17:28,860 --> 00:17:35,220
+هذا البرنامج للفحص والمسح الموليد الجدد مسح كامل
+
+186
+00:17:35,220 --> 00:17:40,740
+في المجتمع أن يكون الـ Clinical Validity يعني
+
+187
+00:17:40,740 --> 00:17:45,160
+الفحص الجانب الأول أنه القدرة التحليلية للفحص شو
+
+188
+00:17:45,160 --> 00:17:51,080
+علاقة الفحص بالمرض هل في علاقة شقوية وأن نكون أخيص
+
+189
+00:17:51,080 --> 00:17:54,820
+وأن نكون سريع وأن نكون أقدر يسوي الفحص هذا بشكل
+
+190
+00:17:54,820 --> 00:18:00,580
+كويسالنقطة الثانية، راح نحكي عنها كمان اللي هي الـ
+
+191
+00:18:00,580 --> 00:18:05,420
+Clinical Validity إنه الـ Laboratory Test Highly
+
+192
+00:18:05,420 --> 00:18:10,420
+Sensitive وHighly Reliable وSpecific والـ Positive
+
+193
+00:18:10,420 --> 00:18:13,720
+Predictive Value is High يعني نازم High، راح جوانب
+
+194
+00:18:13,720 --> 00:18:18,600
+نحكي عنها بالتفصيل، مهمة النحو الثالثة، اللي هي
+
+195
+00:18:18,600 --> 00:18:22,420
+الـ Clinical Utility يعني الاستفادة السرينية أنا
+
+196
+00:18:22,420 --> 00:18:27,960
+والله إذا مرض قاتل وماعندي علاج لهأيش أفحص عليه؟
+
+197
+00:18:27,960 --> 00:18:30,920
+بينما كل اللي أنا بحكي عنه الأمراض كأمثلة
+
+198
+00:18:30,920 --> 00:18:39,500
+الـHypothyroidism بيعمل تخلف عقلي، بيعمل تقزم،
+
+199
+00:18:39,500 --> 00:18:46,200
+بيأخر نمو الطفل، بيعمله مشاكل كبيرة جدا بحبة بسيطة
+
+200
+00:18:46,200 --> 00:18:50,540
+يومياً يتم علاجها وانتهانا وتكون بعيش الإنسان
+
+201
+00:18:50,540 --> 00:18:57,540
+طبيعيفكون إن واحد مثلها في مصير بينقوسين أسود أو
+
+202
+00:18:57,540 --> 00:19:03,280
+مصير سيء بشيء بسيط هذا مشجع على إن الواحد يعمل هذا
+
+203
+00:19:03,280 --> 00:19:07,060
+الفحص فلازم يكون الـ Treatment available Early
+
+204
+00:19:07,060 --> 00:19:10,120
+institution of treatment before symptoms become
+
+205
+00:19:10,120 --> 00:19:13,280
+manifest, reduce or prevail severe illness يعني
+
+206
+00:19:13,280 --> 00:19:17,020
+هذه ناحية ثانية إن الـ Treatment أحيانًا إذا أنا
+
+207
+00:19:18,030 --> 00:19:22,490
+يعني اتطبقتها في الفترة المبكرة قبل حتى ما المريض
+
+208
+00:19:22,490 --> 00:19:28,150
+يشكي يعني إحنا الـ Hypothyroidism هذا على عمر
+
+209
+00:19:28,150 --> 00:19:32,690
+السنتين إذا لم يتم علاجه الطفل هذا متخلف عقليا مدى
+
+210
+00:19:32,690 --> 00:19:38,510
+الحياة يعني كارثة بينما ممكن يكون طبيعي بعلاج بسيط
+
+211
+00:19:38,510 --> 00:19:42,460
+سهل مافيش فيه إشي يعنيالـ «التجارب العادية
+
+212
+00:19:42,460 --> 00:19:46,500
+والتجارب الفيزيوكالية» «لن تظهر المشكلة في الطفولة
+
+213
+00:19:46,500 --> 00:19:51,280
+الجديدة، يتطلب تجارب» أيه كمان يعني حكيناها أنه
+
+214
+00:19:51,280 --> 00:19:57,000
+الفناع الأناني مثلا عند الولادة والـ TSH عند
+
+215
+00:19:57,000 --> 00:20:01,620
+الولادة نفسها قد لا يكون مرتفعة لأن الطفل باخد من
+
+216
+00:20:01,620 --> 00:20:06,060
+أمه أو بخلص من الفناع الأناني عن طريق أمه،
+
+217
+00:20:06,060 --> 00:20:11,710
+فبالتاليما عنده حتى يعني بيكون بيبين من أولها من
+
+218
+00:20:11,710 --> 00:20:16,990
+أول الولادة بعد أسبوع بيكون ممكن يكون أفضل والـ
+
+219
+00:20:16,990 --> 00:20:21,710
+Screening Program نعمل بهذا الوقتالتجارب مستمرة
+
+220
+00:20:21,710 --> 00:20:24,310
+وخاصة كافية لتجارب التجارب بسبب تجارب التجارب بسبب
+
+221
+00:20:24,310 --> 00:20:28,070
+تجارب التجارب بسبب تجارب التجارب بسبب تجارب تجارب
+
+222
+00:20:28,070 --> 00:20:30,610
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+223
+00:20:30,610 --> 00:20:30,650
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+224
+00:20:30,650 --> 00:20:30,650
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+225
+00:20:30,650 --> 00:20:32,390
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+226
+00:20:32,390 --> 00:20:49,670
+تجارب تجارب تجارب تجارب تجارب تجارب تجار
+
+227
+00:20:50,100 --> 00:20:53,640
+يكون عالي إن أعمل الفحص وراح نشوف أمثل على أهمية
+
+228
+00:20:53,640 --> 00:20:58,060
+هذا الجانب والـ Public Health Infrastructure is in
+
+229
+00:20:58,060 --> 00:21:01,400
+place to inform the newborns, parents and
+
+230
+00:21:01,400 --> 00:21:04,160
+physicians of the results of the screening test to
+
+231
+00:21:04,160 --> 00:21:06,920
+confirm the test result and institute effective
+
+232
+00:21:06,920 --> 00:21:11,940
+treatment and counseling لما نيجي في مجتمع نحط هذا
+
+233
+00:21:11,940 --> 00:21:19,460
+البرنامج للمسح للموليد الجدد يجبإن يكون البلد
+
+234
+00:21:19,460 --> 00:21:25,740
+مستقر يجب أن يكون هناك آليات لتخضيع الراجعة شو
+
+235
+00:21:25,740 --> 00:21:31,280
+بفيدني إن أنا والله أعمل دراسة واطلع مثلا 1% عندهم
+
+236
+00:21:31,280 --> 00:21:38,080
+المرض الـ 1% هدولة المفروض إن أنا أروح أكون قادر
+
+237
+00:21:38,080 --> 00:21:42,640
+على الوصول إليهم مرة ثانية بدي بلكن فحص أشياء أقوى
+
+238
+00:21:42,640 --> 00:21:48,310
+للتأكد بدي أنا أفهمهم شو المرض هذاكيف يتعاملوا
+
+239
+00:21:48,310 --> 00:21:51,790
+معاه، كيف يعلجوا، أبلغ الأطباء اللي بيعلجوا
+
+240
+00:21:51,790 --> 00:21:55,810
+الأطفال دولة وبتابعوهم، شو اللي لازم يعمل وكيف
+
+241
+00:21:55,810 --> 00:21:59,850
+لازم يعمل، شو المتباعت بعد ذلك، شو نتيجة أن هذا
+
+242
+00:21:59,850 --> 00:22:04,430
+الفحص إيجابي، على عكس لو كان الحال سلبي، فبالتالي
+
+243
+00:22:04,430 --> 00:22:09,750
+مابدناش أشي في الحالة يعني، فالنقطة الثلاثة هذولة
+
+244
+00:22:09,750 --> 00:22:19,240
+يعنيإن ما سأقوم فيه خلال برنامج المسح الماليد
+
+245
+00:22:19,240 --> 00:22:26,310
+الجددالوطني للبلد بأكملها لكل الناس لازم يكون له
+
+246
+00:22:26,310 --> 00:22:33,930
+قدرة أو فائدة تحليلية وسريرية واستفادة سريرية منه
+
+247
+00:22:33,930 --> 00:22:41,830
+ممكنة غير هيك ما في داعي أن أحط الفحص ضمن معطيات
+
+248
+00:22:41,830 --> 00:22:49,790
+البرنامج الوطني للمساعدة الجدول
+
+249
+00:22:49,790 --> 00:22:58,260
+هذايعني هو جزءي لناحية محددة في الـ… خلّينا نرجع
+
+250
+00:22:58,260 --> 00:23:10,860
+له شوية، لأ مش هذا ثواني، لأ أنا المفروض، هذه
+
+251
+00:23:10,860 --> 00:23:16,560
+النقطة اللي كنت بحكيها الـ… الـCongelital Hearing
+
+252
+00:23:16,560 --> 00:23:22,450
+Loss لما نسوي Screeningيعني لما يجي الطفل على
+
+253
+00:23:22,450 --> 00:23:26,050
+الإيادة
+
+254
+00:23:26,050 --> 00:23:35,070
+لازم أفحص السماعة تبعه وتأكد إنه بيسمع كويسإنه
+
+255
+00:23:35,070 --> 00:23:40,030
+الإنسان لو فقد سمعه يعني اللي هو يعني إنه صار
+
+256
+00:23:40,030 --> 00:23:47,370
+مشكلة في الأذن مثلا بعد البلوغ أو بعد سنتين وثلاثة
+
+257
+00:23:47,370 --> 00:23:52,670
+بحيث إنه تتكون عنده اللغة يصبح الاستعادة السمع
+
+258
+00:23:52,670 --> 00:23:59,110
+والاتعامل معاه ممتاز لأنه على الأقلالنظم العقلي
+
+259
+00:23:59,110 --> 00:24:04,550
+العصبي للتعامل مع السماء بتظل سليمة وبيكون الإنسان
+
+260
+00:24:04,550 --> 00:24:10,310
+بيقدر يعني دماغه مستطيع التعامل مع اللغة والسمع
+
+261
+00:24:10,310 --> 00:24:16,020
+والكلام بيقدر يتكلمالآن الـ Sensory Neuronal
+
+262
+00:24:16,020 --> 00:24:24,440
+Hearing Loss إذا كان في الطفولة قبل ما مثلاً يعني
+
+263
+00:24:24,440 --> 00:24:31,480
+قبل السنة و سنتين و ثلاثة بقدر أركب لهم الآن قوقعة
+
+264
+00:24:31,480 --> 00:24:39,560
+القوقعة يعني زي سماعة خارجية موصولة بأسلاك داخل
+
+265
+00:24:39,560 --> 00:24:46,170
+الأذن الداخلية على القوقعةفبالتالي، يعني ممكن
+
+266
+00:24:46,170 --> 00:24:52,050
+تعويضها ممكن بدل ما الإنسان أطرم، أبكه، أصم، لا
+
+267
+00:24:52,050 --> 00:24:57,250
+يسمع، لا يتكلم، لا يستطيع ان يتعامل مع الناس،
+
+268
+00:24:57,250 --> 00:25:02,490
+بخليه إنسان طبيعي، حتى لو الإنسان يعني فقد السمع
+
+269
+00:25:02,490 --> 00:25:07,670
+بعدين، ممكن من حركة الشفائف يتعلق، يكون يقدر يفهم
+
+270
+00:25:07,670 --> 00:25:11,710
+شو اللي أمامه بيحكي، شو اللي أشياء، يعني ناحية
+
+271
+00:25:11,710 --> 00:25:19,180
+مهمة جدافإذا اكتشفنا إنه في طفل عنده سمع مشكلة في
+
+272
+00:25:19,180 --> 00:25:24,620
+السمع مبكر فرق السمع على الأرض كيف علاجه ويكون
+
+273
+00:25:24,620 --> 00:25:29,180
+يعني يستطيع يتكلم ويفهم غيره ويفهم على غيره وكذا
+
+274
+00:25:29,180 --> 00:25:35,600
+فهذه مشكلة يعني كبيرة بقية الأمراض والحالات برضه
+
+275
+00:25:35,600 --> 00:25:42,870
+في عليها إشكالات الـكل اللي بيحكوا عنه في هذا
+
+276
+00:25:42,870 --> 00:25:50,810
+الفحص، في هذه الـ Lista اللي هي، نشوف الكلمة اللي
+
+277
+00:25:50,810 --> 00:25:55,050
+فوق اللي هي «Tandem Mass Spectrometry» راح أنا بقى
+
+278
+00:25:55,050 --> 00:26:01,750
+هيتعلمتها جديد مع المحاضرة تبعتكمعشان أن هذا هو
+
+279
+00:26:01,750 --> 00:26:06,230
+نوعية الفحص اللي يستخدم بالفحص اللي حكيت عنه في
+
+280
+00:26:06,230 --> 00:26:10,730
+قضية نقطة الدم على ورقة النشاف اللي إحنا بندور
+
+281
+00:26:10,730 --> 00:26:19,910
+عليها، بنجمعها فهناك، يعني هنا تقريبًا بقدر بجز،
+
+282
+00:26:19,910 --> 00:26:26,970
+يعني يعني أمامي بقدر يمكن خمسين مرض، أربعين مرض
+
+283
+00:26:27,750 --> 00:26:33,030
+اللي حاطين يمكن تشخيصهم عن طريق اللي لو حاطينه لقم
+
+284
+00:26:33,030 --> 00:26:37,210
+واحد الـ BQ يعني أنا كل التعامل مع هذا الجانب من
+
+285
+00:26:37,210 --> 00:26:41,630
+خلال الـ BQ اللي عندي خبرة فيه البقية، قداش والله
+
+286
+00:26:41,630 --> 00:26:48,710
+شائعة في مجتمعاتنا وكم حالة منها يعني في القردن،
+
+287
+00:26:48,710 --> 00:26:54,270
+هذول البقية إحنا بنقول عنهم الأمراض الاستقلابية أو
+
+288
+00:26:54,270 --> 00:27:00,490
+الـ Metabolic Disordersولمّا فيه عندنا مراكز وطنية
+
+289
+00:27:00,490 --> 00:27:04,630
+للوراثة ومركز وطني للسكر والوراثة والأمراض
+
+290
+00:27:04,630 --> 00:27:08,690
+الوراثية فيه إيش في الخدمات وفيه إيش في الجامعة
+
+291
+00:27:08,690 --> 00:27:14,810
+الأردنية بنقدر إن الأردن فيها حوالي بي كيو
+
+292
+00:27:14,810 --> 00:27:19,550
+أربعمائة حالة عندنا موجودين ومتعامل معهم ويلهم
+
+293
+00:27:19,550 --> 00:27:24,580
+طريقة علاج معينة وكذا وكذاأو بقدروا في كل الأردن
+
+294
+00:27:24,580 --> 00:27:29,640
+حوالي 800 حالة 400 لـ 800 مكتشفين وغير مكتشفين
+
+295
+00:27:29,640 --> 00:27:35,820
+ومنها الـ Reds بينما لكل الأمراض التانية فيها
+
+296
+00:27:35,820 --> 00:27:41,720
+بحدود above 300 حالة فالبقية غير الـ PQ يعني
+
+297
+00:27:41,720 --> 00:27:49,420
+نسبتها أقل وإن كان وإن كان يمكن في عائلات معينة
+
+298
+00:27:49,420 --> 00:27:54,990
+نلاقي مشاكل محددةوبسبب زواج الأقارب وهذا الموضوع
+
+299
+00:27:54,990 --> 00:28:00,850
+هناك أمراض كثيرة على الأقل هنا قاعدة جزئية بحوالي
+
+300
+00:28:00,850 --> 00:28:05,770
+خمسين مرض متابوليت الـ Disorder الفكرة هنا شتنتين
+
+301
+00:28:05,770 --> 00:28:13,910
+أنه نوعية الفحص اللي بستخدمه لإكتشاف
+
+302
+00:28:13,910 --> 00:28:17,930
+هذه مجموعة من الأمراض هو الـ 10D Mass Spectrometry
+
+303
+00:28:17,930 --> 00:28:25,150
+هذا اسم الفحصوهو على ورقة النشاف تانديم يعني إشي
+
+304
+00:28:25,150 --> 00:28:29,670
+ورا الثاني وmass spectrometry اللي هو على الكتلة
+
+305
+00:28:29,670 --> 00:28:34,450
+شغل في الكتل يعني أنا ما بفهم تفاصيل الفنية كيف
+
+306
+00:28:34,450 --> 00:28:39,730
+هذا الفحص يعمل بس لعدد كبير من الـmetabolites
+
+307
+00:28:39,730 --> 00:28:49,230
+بتكون وبكون سهل جداًوسريع وبدنا بعدين ندخل في يعني
+
+308
+00:28:49,230 --> 00:28:56,950
+ندخل في كيفية متابعة الحالة الإيجابية وكيف نسوي
+
+309
+00:28:56,950 --> 00:29:00,870
+لهم counseling شو لازم أعمل؟ شو لحل؟ شو الأدوية
+
+310
+00:29:00,870 --> 00:29:04,450
+تبعتها؟ شو بعدين ممكن يعمل؟ شو المستقبل لهذه
+
+311
+00:29:04,450 --> 00:29:09,270
+الحالة؟ فالنقطة الأولى إنه اسمه «Tandem Mass
+
+312
+00:29:09,270 --> 00:29:14,470
+Spectrometry» النقطة الثانيةاللي هي إن هناك ثلاث
+
+313
+00:29:14,470 --> 00:29:18,210
+أنواع من الـ Metabolic Disorders فيه Amino Acid
+
+314
+00:29:18,210 --> 00:29:22,770
+Disorder فيه Organic Acid Disorder فيه Fatty Acid
+
+315
+00:29:22,770 --> 00:29:27,690
+Oxidation Disorder يعني،
+
+316
+00:29:27,690 --> 00:29:34,950
+ماعرفش، أنا نفسي مش حافظ إن هاي تاب على كده وهاي
+
+317
+00:29:34,950 --> 00:29:38,750
+تاب على كده وهاي تاب على كده اللي بعرفه الـ Bq
+
+318
+00:29:38,750 --> 00:29:45,990
+Amino Acidيعني هي النقطة القوية والأساسية يعني
+
+319
+00:29:45,990 --> 00:29:50,730
+هيستسلون نحتاج نطلع عليهم ولا ما نطلعش عليهم ولا
+
+320
+00:29:50,730 --> 00:29:56,890
+إذا الواحد بيشوف يعني أنا على الأقل يعني النقطة
+
+321
+00:29:56,890 --> 00:30:00,900
+اللي بدي إياهااللي هي إنه فيه Amino Acid
+
+322
+00:30:00,900 --> 00:30:04,760
+Disorders، فيه Organic Acid Disorders، والواحد دي
+
+323
+00:30:04,760 --> 00:30:08,560
+كيقرا الأسامي، وفيه Fatty Acid Oxidation
+
+324
+00:30:08,560 --> 00:30:13,400
+Disorders، هدول الثلاثة، يعني يمكن يمكن يجيكم في
+
+325
+00:30:13,400 --> 00:30:17,670
+الامتحان مثلا إنهالشيء الوحيد اللي يمكن ان يتم
+
+326
+00:30:17,670 --> 00:30:20,610
+اكتشافه هو الـ Tandem Mass Spectrometry الوحيد
+
+327
+00:30:20,610 --> 00:30:22,510
+اللي يمكن ان تم اكتشافه هو الـ Tandem Mass
+
+328
+00:30:22,510 --> 00:30:23,630
+Spectrometry الوحيد اللي يمكن ان تم اكتشافه هو الـ
+
+329
+00:30:23,630 --> 00:30:28,470
+Tandem Mass Spectrometry الوحيد
+
+330
+00:30:28,470 --> 00:30:29,850
+اللي يمكن ان تم اكتشافه هو الـ Tandem Mass
+
+331
+00:30:29,850 --> 00:30:30,530
+Spectrometry الوحيد اللي يمكن ان تم اكتشافه هو الـ
+
+332
+00:30:30,530 --> 00:30:33,630
+Tandem Mass Spectrometry الوحيد اللي يمكن ان تم
+
+333
+00:30:33,630 --> 00:30:37,130
+اكتشافه هو الـ
+
+334
+00:30:37,130 --> 00:30:37,410
+Tandem Mass Spectrometry الوحيد اللي يمكن ان تم
+
+335
+00:30:37,410 --> 00:30:39,450
+اكتشافه هو الـ Tandem Mass Spectrometry الوحيد
+
+336
+00:30:39,450 --> 00:30:41,190
+اللي يمكن ان تم اكتشافه هو الـ Tandem Mass
+
+337
+00:30:41,190 --> 00:30:47,370
+Spectrometry الوحيد اللي يمكن ان تم ايعني مش
+
+338
+00:30:47,370 --> 00:30:52,950
+موجودة بس أنا بتوقع نقطتين مهمات اللي هم الـ 10D
+
+339
+00:30:52,950 --> 00:30:59,030
+Mass Spectrometry وبكون هذا فحص بيقولك أشياء كثيرة
+
+340
+00:30:59,030 --> 00:31:07,890
+وهذا فحص simple ويعتمد على نقطة دم جاذبة من كعب
+
+341
+00:31:07,890 --> 00:31:13,730
+الطفل تفحص فيها على أشياء كتيرمثل هذا النوع من
+
+342
+00:31:13,730 --> 00:31:19,570
+الفحص، الورقة هذه أنا بعرف إنه في دول ومجتمعات
+
+343
+00:31:19,570 --> 00:31:24,670
+بتسوي إلى اللي هو نرجع هنا لـ Severe Combined
+
+344
+00:31:24,670 --> 00:31:27,470
+Immune Deficiency Severe Combined Immune
+
+345
+00:31:27,470 --> 00:31:34,390
+Deficiency على الأقل في حوالي 160 إلى ما كانش
+
+346
+00:31:34,390 --> 00:31:39,320
+وصلوا لـ 200 الآن Different Genetic Mutationsففيها
+
+347
+00:31:39,320 --> 00:31:42,980
+طريقة إنه برضه يفحصوا على الـ Severe Combined
+
+348
+00:31:42,980 --> 00:31:49,100
+Immune Deficiency البقية لها فحصات أخرى، الأخر
+
+349
+00:31:49,100 --> 00:31:54,140
+أربع تحت شكلهم من تبعات الـ Metabolic Disorders
+
+350
+00:31:54,140 --> 00:32:02,160
+التانية اللي بتدخل هنا فالنقطة
+
+351
+00:32:02,160 --> 00:32:07,380
+يعني الآن يعنيإذا بنتكلم على مبدأ الـ Personalized
+
+352
+00:32:07,380 --> 00:32:11,200
+Medicine فالنقطة الأولى كانت إنه إذا بعرف الـ
+
+353
+00:32:11,200 --> 00:32:17,340
+History في شيء له جانب وراثي كويس وقوي المفروض
+
+354
+00:32:17,340 --> 00:32:20,640
+أستفيد منه في التعامل مع المرضى زي الـ Colon
+
+355
+00:32:20,640 --> 00:32:26,620
+Cancer الموضوع الثاني إنه أنا لازم كمجتمع كنظام
+
+356
+00:32:26,620 --> 00:32:35,170
+صحي أسوي اللي هم الـ Screening Programاللي هو
+
+357
+00:32:35,170 --> 00:32:43,550
+برنامج مسح الوطني للأمراض
+
+358
+00:32:43,550 --> 00:32:50,730
+الوراثية أو الممكنة عند الأطفال حدثي الولادة النوع
+
+359
+00:32:50,730 --> 00:32:55,550
+الثالث في الـ Personalized Medicine هي قضية الـ
+
+360
+00:32:55,550 --> 00:33:04,520
+Pharmacogenetics يعني علم الأدوية الوراثيوتداخل
+
+361
+00:33:04,520 --> 00:33:09,980
+الوراثة مع الدواء وتأثير الدواء على الإنسان فمن
+
+362
+00:33:09,980 --> 00:33:15,620
+أهم الجوانب، يعني يمكن سمعتها من قبل تقريبًا كثير
+
+363
+00:33:15,620 --> 00:33:20,720
+من الأدوية يتم يعني في جزء أقل يتم التخلص منه عن
+
+364
+00:33:20,720 --> 00:33:26,220
+طريق الـ Ball مباشرة للدواء نفسه بيكون عن طريق الـ
+
+365
+00:33:26,220 --> 00:33:30,520
+Ball من طريق الكلاب بس في كثير من الأدوية بتتم
+
+366
+00:33:30,520 --> 00:33:36,120
+التعامل معها عن طريقالـ CABID والـ Metabolism
+
+367
+00:33:36,120 --> 00:33:42,700
+عمليات أيضًا بتغير طبيعة الدواء وبالتالي بتعمل من
+
+368
+00:33:42,700 --> 00:33:50,500
+هذا الدواء شيء بيكون يعني بعد ما كان مستحيل التخلص
+
+369
+00:33:50,500 --> 00:33:55,580
+منه بشكل سريع بيصير من خلال الـ Ball يتم التخلص
+
+370
+00:33:55,580 --> 00:34:00,740
+منه في أسئلة إن شاء الله أنه كلامي واضح وشرح
+
+371
+00:34:00,740 --> 00:34:07,460
+مفهومهما فيش مشاكل إذا كريم بده يسأل بالذات أنا
+
+372
+00:34:07,460 --> 00:34:15,340
+حاضر إذا عنده سؤال كريم ماشي
+
+373
+00:34:15,340 --> 00:34:20,280
+فالنقطة
+
+374
+00:34:20,280 --> 00:34:27,800
+اللي بدنا نذكرها إنه تعامل الأدوية بسبب الوراثة
+
+375
+00:34:27,800 --> 00:34:34,720
+وتعامل الجسم مع الأدوية بسبب الوراثة جانب مهمويعني
+
+376
+00:34:34,720 --> 00:34:41,040
+هناك كثير من الأدوية اللي بيكون فيها دوانة معينة
+
+377
+00:34:41,040 --> 00:34:46,700
+في تعامل الجسم معها أحيانًا يتم التعرف على، نحن
+
+378
+00:34:46,700 --> 00:34:55,700
+بنقسم الناس لثلاث أقسام اللي هم يعني، يعني حاطينهم
+
+379
+00:34:55,700 --> 00:35:01,740
+هنا الـPoor Metabolizer الشخص اللي جسمه بيقدرش
+
+380
+00:35:01,740 --> 00:35:08,330
+يتعاملمع الدواء بشكل سريع وفيه الـNormal
+
+381
+00:35:08,330 --> 00:35:12,330
+Metabolizer والـUltra-fast Metabolizer الـUltra
+
+382
+00:35:12,330 --> 00:35:18,470
+-fast هو اللي بيكون يعني جسمه بتعامل مع الدواء
+
+383
+00:35:18,470 --> 00:35:24,370
+بشكل سريع جداً فالكلام طبعاً، ليش الـLiver
+
+384
+00:35:24,370 --> 00:35:29,050
+Metabolism؟ هو الـLiver مصنع الكيموي تبع الجسم
+
+385
+00:35:29,050 --> 00:35:34,360
+آلافالعمليات الكيميائية بتتم في الكبد سبحان الله
+
+386
+00:35:34,360 --> 00:35:39,040
+كيف خلق الله للإنسان وكيف الكبد والكبد يعني ميزته
+
+387
+00:35:39,040 --> 00:35:44,900
+إنه إذا أكلت شيء أو شربت شيء أو دخل شيء في الأمعاء
+
+388
+00:35:44,900 --> 00:35:49,740
+لازم يمر على الكبد قبل ما يدخل لبقية الجسم ففي شيء
+
+389
+00:35:49,740 --> 00:35:53,780
+بيسموه، عرفته عنه اسمه الـ First Pass Metabolism
+
+390
+00:35:53,780 --> 00:36:00,720
+فإحنا بنقسم الناس أحيانًا لبعض الأدويةإنه فيه
+
+391
+00:36:00,720 --> 00:36:04,900
+الإنسان بتعامل مع الدواء هذا بشكل بطيء وما بتقدر
+
+392
+00:36:04,900 --> 00:36:09,440
+يتعامل معاه بشكل المناسب أو السريع فإحنا جزء من
+
+393
+00:36:09,440 --> 00:36:14,320
+بالذات الأدوية اللي لازم تُخر بشكل مزمن ولازم يكون
+
+394
+00:36:14,320 --> 00:36:18,740
+لها مستوى جيد حتى اللي بيسميه في الـ Pharmacology
+
+395
+00:36:18,740 --> 00:36:24,360
+في علم الأدوية الـ Therapeutic Index يعنيالمدى
+
+396
+00:36:24,360 --> 00:36:31,440
+المفيد أو الصحي أو المعالج عكس أنه لما نوصل لمستوى
+
+397
+00:36:31,440 --> 00:36:38,640
+السمي أو اللي هو أعلى من المطلوب فالإنسان لو كان
+
+398
+00:36:38,640 --> 00:36:45,640
+poor-metabolizer إحنا مرات كثيرة بنعمل الدواء حتى
+
+399
+00:36:45,640 --> 00:36:50,700
+نوصل ما يسمى الـSteady State الـSteady State يعني
+
+400
+00:36:50,700 --> 00:36:54,940
+زي اللي بالنص هي المناسبة، هي المطلوبةيكون الدواء
+
+401
+00:36:54,940 --> 00:36:59,260
+كل الوقت ضمن الـ Range المطلوب طبعاً لما أنا أخد
+
+402
+00:36:59,260 --> 00:37:04,060
+أي حب الدواء أو حد يعطينا إبرد دواء راح فجأة
+
+403
+00:37:04,060 --> 00:37:08,880
+أتلافي مستوى الدواء يعلى كثير ومع ذلك يرجع وينزل،
+
+404
+00:37:08,880 --> 00:37:14,060
+ماشي؟ فالفكرة لماذا بعض الأدوية بنعطيها مثلاً إذا
+
+405
+00:37:14,060 --> 00:37:19,180
+بتنتبه مرة باليوم، مرتين باليوم، أربع مرات باليوم،
+
+406
+00:37:19,180 --> 00:37:22,420
+في أدوية خمس مرات باليوم، لماذا بنعطيها بهذه
+
+407
+00:37:22,420 --> 00:37:26,710
+التفصيل؟لماذا يقول الشركة والمصنّي على الدواء
+
+408
+00:37:26,710 --> 00:37:29,130
+بتقولّك لما تدرس الـ Pharmacodynamics
+
+409
+00:37:29,130 --> 00:37:34,630
+وPharmacokinetics تبع الدواء، ماشي، بتقولّه إن
+
+410
+00:37:34,630 --> 00:37:39,010
+مثلا هذا لازم يستخدم بهذا المدّي يعني كل مرتين،
+
+411
+00:37:39,010 --> 00:37:42,910
+ثلاث، أربع باليوم، مرة باليوم ممكنة ولا لأ؟
+
+412
+00:37:42,910 --> 00:37:47,330
+فالـEndonormal
+
+413
+00:37:47,330 --> 00:37:51,590
+Metabolism ومنعطيه الـDose بالشكل المتوقع الطبيعي
+
+414
+00:37:51,960 --> 00:37:56,620
+الأصل إنه يظل مستوى الدواء ضمن الـ Range المطلوب
+
+415
+00:37:56,620 --> 00:38:02,020
+وهذا الإنسان الحالي المطلوب بينما إذا كان إنسان
+
+416
+00:38:02,020 --> 00:38:06,040
+poor متابوليزر اللي راح يصير إذا طبقت نفس النظام
+
+417
+00:38:06,040 --> 00:38:09,740
+عليه راح يكون نتيجة الأمر هذا إنه يصبح هناك
+
+418
+00:38:09,740 --> 00:38:14,520
+accumulation تجمع للدواء في الجسم لحيث إنه يصل إنه
+
+419
+00:38:14,520 --> 00:38:20,600
+يكون على مستوى أو حد ثمني يسبب مرض ويسبب مشكلة
+
+420
+00:38:21,290 --> 00:38:24,730
+فبتكون هذا في الـ Pore Metabolizer وضلتني أعطي نفس
+
+421
+00:38:24,730 --> 00:38:29,730
+الطريقة في مقابل إنه لو عندي واحد سريع جدا و أسرع
+
+422
+00:38:29,730 --> 00:38:34,450
+من المعتاد النتيجة إنه مرحلة قفايدة من الدواء لأن
+
+423
+00:38:34,450 --> 00:38:37,930
+أصلا الدواء ما صارش في المستوى الكويس اللي يعطيني
+
+424
+00:38:37,930 --> 00:38:42,350
+النتيجة اللي المطلوبة فبتكون هذا يبدو زيدي الجرعة
+
+425
+00:38:42,760 --> 00:38:48,480
+وبدّو يزيد أو يقلل مدة بين الدواء الجرعة والثانية
+
+426
+00:38:48,480 --> 00:38:59,280
+عشان يعني يوصل إنه يعني يكون يكون بشكل جيد يعني
+
+427
+00:38:59,280 --> 00:39:06,220
+فهذه الأنواع الثلاثة للجسم لما نتكلم عن الأدوية
+
+428
+00:39:06,220 --> 00:39:15,410
+والإنسان كيف التعامل معاهالملاحظ أن أهم مجموعة
+
+429
+00:39:15,410 --> 00:39:25,670
+إنزيمات بتتم بتسوي هذا الموضوع اللي هو الـ
+
+430
+00:39:25,670 --> 00:39:33,790
+«Cytochrome-B» «Cytochrome-B» هو إنزيم دخل في قضية
+
+431
+00:39:35,070 --> 00:39:39,210
+يعني الـ Metabolism لكثير من الأدوية وكثير من
+
+432
+00:39:39,210 --> 00:39:43,050
+المُركّبات داخل الجسم هو من أهم الإنزيمات، بس في
+
+433
+00:39:43,050 --> 00:39:49,010
+غيره، وفي أشياء ثانية فهذا
+
+434
+00:39:49,010 --> 00:39:57,790
+لائحة أو جدول لما هو معلوم أو يُنصح به في حالات
+
+435
+00:39:57,790 --> 00:40:04,870
+إعطاء أدوية معينة إنه يتم الانتباه لناحية معينة
+
+436
+00:40:05,390 --> 00:40:09,870
+لأنها بتفرق كثير بين Slow Metabolizer و Ultra-Fast
+
+437
+00:40:09,870 --> 00:40:14,310
+Metabolizer وهدولة فيه نسب كبيرة منهم لحيث إنه
+
+438
+00:40:14,310 --> 00:40:20,110
+مرات بيخربطك وبيخلي الدواء يكون فيه مشكلة الجدول
+
+439
+00:40:20,110 --> 00:40:27,710
+هذا أنا بس بدي أركز على ناحية تانية الناحية الأولى
+
+440
+00:40:29,340 --> 00:40:36,800
+هذه الأشياء اللي متفق عليها أو في دليل علمي تجاربي
+
+441
+00:40:36,800 --> 00:40:46,400
+قوي على كيفية تعامل الجسم مع هذه الأدوية المثال
+
+442
+00:40:46,400 --> 00:40:52,240
+الأول يعني اللي هو معروف ومشهور التفول الـ G6PD
+
+443
+00:40:52,240 --> 00:41:01,940
+«كل جدول بديشية»ممكن تقرأوا عن الـ HLA-B5701 على
+
+444
+00:41:01,940 --> 00:41:07,020
+الأبا كافير حاطينه بـ Case 1 كمثال، هي
+
+445
+00:41:07,020 --> 00:41:10,600
+Individualized Medicine يعني أنت لما بتشوف بني آدم
+
+446
+00:41:10,600 --> 00:41:13,540
+عنده شغل معين بتقدر تعطيه أو بتقدرش تعطيه هذا
+
+447
+00:41:13,540 --> 00:41:20,130
+الأشياء فالأدوية زي الـ Chloroquineدول ملاريا الـ
+
+448
+00:41:20,130 --> 00:41:25,370
+Prima Queen برضه يستخدم في الملاريا الـ Dapsin
+
+449
+00:41:25,370 --> 00:41:31,030
+برضه يستخدم في أمراض كثيرة كجزء وأدوية ثانية
+
+450
+00:41:31,030 --> 00:41:34,930
+الممنوع
+
+451
+00:41:34,930 --> 00:41:38,870
+يأخذها الـ G6PD الكلوراكوين أو الـ
+
+452
+00:41:38,870 --> 00:41:42,370
+Hydroxychloroquine مع أدوية ثانية اللي عندهم تفوّل
+
+453
+00:41:42,370 --> 00:41:46,300
+اللي هو الـ G6PD deficiencyالذي عنده نقص هذا
+
+454
+00:41:46,300 --> 00:41:49,460
+الانزيم أو ميوتاشيا في هذا الانزيم أو Extinct
+
+455
+00:41:49,460 --> 00:41:53,300
+Recidivism بيصير عنده تفول اللي منقوله بيصير
+
+456
+00:41:53,300 --> 00:41:57,560
+Hemolysis وبذات الـ Chloroquine فالأصل إذا أنا بدي
+
+457
+00:41:57,560 --> 00:42:02,040
+أعطي إنسان Chloroquine أو كده أسأله أفحصه على الـ
+
+458
+00:42:02,040 --> 00:42:07,020
+G6PD فهذا مثال على Individualized Medicine بالنسبة
+
+459
+00:42:07,020 --> 00:42:14,290
+للـ Pharmacogenetics على الـ G6PDالـ Cytochrome
+
+460
+00:42:14,290 --> 00:42:19,850
+وفيه إنزيمات ثانية ما بدنا شيها كتير كتير كتير بس
+
+461
+00:42:19,850 --> 00:42:25,870
+الـ G6PD الدوة الثانية اللي بين قوسين بيجنن وبيخل
+
+462
+00:42:25,870 --> 00:42:30,210
+الواحد ماعرفش مرات كيف يتعامل معاه اللي هو الـ
+
+463
+00:42:30,210 --> 00:42:35,010
+Warfarin الـ Warfarin اسمه Comodin أو مرات إله
+
+464
+00:42:35,010 --> 00:42:42,280
+أسماء ثانية عبارة عن مميّع للدمالـ Warfarin هو
+
+465
+00:42:42,280 --> 00:42:50,000
+Vitamin K انهيبتر فالـ Plotting Factors اللي هم
+
+466
+00:42:50,000 --> 00:43:00,000
+1972، عشرة و تسعة و سبعة و اثنين بيكونوا Dependent
+
+467
+00:43:00,000 --> 00:43:04,100
+و كلهم من الـ Liver في الغالبكل الـ Coagulation
+
+468
+00:43:04,100 --> 00:43:10,620
+Factors من اللفر بس الـ Oral Vitamin K Inhibitor
+
+469
+00:43:10,620 --> 00:43:16,600
+اللي هو الـ Warfarin بيمنع هدولة الأربعة بالذات
+
+470
+00:43:16,600 --> 00:43:20,240
+معاهم
+
+471
+00:43:20,240 --> 00:43:26,240
+الـ Protein C و Protein S برضه بتتم تصنيعهم في
+
+472
+00:43:26,240 --> 00:43:33,050
+الكبد بتأثير الـ Warfarinفالـ Warfarin بيجنن يعني
+
+473
+00:43:33,050 --> 00:43:37,370
+لما نيجي نضطر لشخص عنده جلطة خايفين أنه يصير عنده
+
+474
+00:43:37,370 --> 00:43:42,870
+جلطة في الأوردة، جلطة على القلب، جلطة هنا، جلطة
+
+475
+00:43:42,870 --> 00:43:51,450
+هناك، بدي أعطيه مميع، فالـ Warfarin من الأدوية في
+
+476
+00:43:51,450 --> 00:43:57,430
+مرات في ناس بيكونوا حسسين جدا، بعطيهمو1 ميلي جرام
+
+477
+00:43:57,430 --> 00:44:02,270
+بيتلاقي ميعله الدم كتير أو بالعكس، في ناس بعطيهم
+
+478
+00:44:02,270 --> 00:44:05,750
+خمس حبات، خمس ميلي جرام، يعني خمس وعشرين ميلي
+
+479
+00:44:05,750 --> 00:44:10,630
+جرام، بيتلاقي لسه دمه مش ميعل، احنا بنعتمد على الـ
+
+480
+00:44:10,630 --> 00:44:15,190
+BTINR الـ Brothrombin Time International
+
+481
+00:44:15,190 --> 00:44:20,830
+Normalized Ratio هدولة نطلع على في حالة الـ
+
+482
+00:44:20,830 --> 00:44:27,190
+Warfarinوبكون يعني في صعوب بالغ أحيانًا كثيرة أنه
+
+483
+00:44:27,190 --> 00:44:33,030
+نظبط الموضوع غير موضوع الـ Metabolism هذا الـ
+
+484
+00:44:33,030 --> 00:44:36,170
+Warfarin
+
+485
+00:44:36,170 --> 00:44:42,750
+يعني جزء من الأحيان التأثير العكسي لموضوع الـ
+
+486
+00:44:42,750 --> 00:44:47,050
+Cytochrome B450
+
+487
+00:44:47,050 --> 00:44:54,550
+اللي هو أهم واحد واللي له أنواعمفهوم إنه في بعض
+
+488
+00:44:54,550 --> 00:44:58,690
+الأدوية بتنشطه وفي بعض الأدوية بتضعفه وتمنعه
+
+489
+00:44:58,690 --> 00:45:02,430
+فتأثيره على هذا الأمر إنه بيصير عندي Drug Drug
+
+490
+00:45:02,430 --> 00:45:06,530
+Interaction بيصير عندي إنه إذا الدوة اللي فلاني
+
+491
+00:45:06,530 --> 00:45:10,930
+أخده إنسان ما بيصيرش يأخذ الدوة اللي فلاني لأنه
+
+492
+00:45:10,930 --> 00:45:14,650
+بيصير Drug Drug Interaction وبتكون هذه يمكن أوضح
+
+493
+00:45:14,650 --> 00:45:20,810
+في اللي عندهم خواصة جينية معينة فاللي بدي تحفظه
+
+494
+00:45:20,810 --> 00:45:26,060
+عشانالكلام اللي حكيناه، خلّيني نركز على الـ
+
+495
+00:45:26,060 --> 00:45:29,940
+Warfarin بقية الأشياء أدوية كثير مهمة، أدوية
+
+496
+00:45:29,940 --> 00:45:36,780
+بنتعامل معاها كثير أحياناً نوع من المرضى بحتاجوه،
+
+497
+00:45:36,780 --> 00:45:41,300
+وتفاصيلها بديشية الـ Warfarin
+
+498
+00:45:47,210 --> 00:45:50,830
+VKORC1 طبعاً الـ Genes بيكون الـ Capital Letters
+
+499
+00:45:50,830 --> 00:45:54,650
+وكل هنا، احنا بنتكلم على مستوى الـ Gene طبعاً كل
+
+500
+00:45:54,650 --> 00:45:58,270
+Gene المفروض انه يطلق Enzyme بيكون واحد يدور شو هو
+
+501
+00:45:58,270 --> 00:46:08,130
+و اين شغله و كده فالـ VKORC1 و الـ Cytochrome B2C9
+
+502
+00:46:08,130 --> 00:46:14,790
+هذولة يعني احفظوا انه اللي مدخل بالـ Warfarinأتوقع
+
+503
+00:46:14,790 --> 00:46:18,350
+يعني سواء أنا بدي أجيب أسئلة أو يمكن الـUSA مليه
+
+504
+00:46:18,350 --> 00:46:22,350
+يعني الواحد يتطلع الجدول هذا ويحاول يستوعب منه
+
+505
+00:46:22,350 --> 00:46:26,490
+أكتر ما بيقدر كل دوة رفع مبسيطة أعزونية، زيدل،
+
+506
+00:46:26,490 --> 00:46:32,670
+باريزيناميد، هدولة للـTB الـisopropionid-3 مشهور
+
+507
+00:46:32,670 --> 00:46:37,730
+ومعروف والهيدرالازين للضغط كلهم أنواع عدوية في كل
+
+508
+00:46:37,730 --> 00:46:44,360
+واحد لهجين معين مهم إن الواحد يتعلم إنه شو تأثيره
+
+509
+00:46:44,360 --> 00:46:48,080
+وشو تأثير الدواء على هذا الجين وهي الناحي المهمة
+
+510
+00:46:48,080 --> 00:46:57,900
+الـ Cytochrome يعني تقريبًا Cytochrome B450 القليل
+
+511
+00:46:57,900 --> 00:47:01,540
+استبعاته أو أنواعه الـ enzymes اللي بتدخل في الـ
+
+512
+00:47:01,540 --> 00:47:06,590
+Drug Metabolism يعني عددها كبير هي أكبر مجموعةو
+
+513
+00:47:06,590 --> 00:47:10,130
+تقريبًا تسعين بالمية من الأدوية تسعين بالمية من
+
+514
+00:47:10,130 --> 00:47:14,430
+الأدوية بتتم الـ Metabolism تبعها من خلال هذا
+
+515
+00:47:14,430 --> 00:47:20,410
+النضعف فكل ما إنسان عنده قليل معين ممكن يكون Slow
+
+516
+00:47:20,410 --> 00:47:26,850
+أو Fast Acetylator أو Fast Metabolizer وكذا وهذه
+
+517
+00:47:26,850 --> 00:47:31,710
+الأنواع تبعتهم ويعني المبدأ أنا مابديش أساس
+
+518
+00:47:31,710 --> 00:47:38,500
+التفاصيل هذا Cytochrome 3A4أو كروم B3A4 مثلاً، لا
+
+519
+00:47:38,500 --> 00:47:42,740
+أريد أن يكون هذا يمكن أن واحد ينتبه عليها إنه أكثر
+
+520
+00:47:42,740 --> 00:47:47,820
+واحد بـ 34% هذا حسب دراسة معينة في population معين
+
+521
+00:47:47,820 --> 00:47:52,880
+في وقت معين، هكذا لك فأهمية
+
+522
+00:47:52,880 --> 00:47:57,340
+الموضوع هذا أنه
+
+523
+00:47:57,340 --> 00:48:04,200
+نشوف هذا الجدول اللي فوق ماشي
+
+524
+00:48:08,610 --> 00:48:14,890
+إنه الإحتمالات أحيانًا اللي نتكلم عنها هو دراسة
+
+525
+00:48:14,890 --> 00:48:19,170
+فيه إذا الواحد بيرجع إلى المرجع تبعها اللي هو
+
+526
+00:48:19,170 --> 00:48:23,230
+«Cytochrome B450»
+
+527
+00:48:23,230 --> 00:48:32,150
+النوعية تبعته «2D6» هذا النوعية لما نيجي لهذا الـ
+
+528
+00:48:32,150 --> 00:48:38,400
+«إنزايم» بالذاتوأشوف ما هي الـ Alleles ما هي
+
+529
+00:48:38,400 --> 00:48:45,460
+المتغيرات أو أنواع الجين هذا بلاقيهم يا إما الـ
+
+530
+00:48:45,460 --> 00:48:51,780
+Wild-type اللي هو الإعتياد اللي موجود عند الناس أو
+
+531
+00:48:51,780 --> 00:48:57,220
+عند الغالبية وإذا في بعضهم ممكن Completely Absent
+
+532
+00:48:57,220 --> 00:49:04,630
+يعني هذا صفرفي بعضهم موجود بس مش شغل كامل Reduced
+
+533
+00:49:04,630 --> 00:49:09,970
+وفي بعضهم بيكون لأ Fast Metabolizer وIncreased
+
+534
+00:49:09,970 --> 00:49:19,570
+Rate of That Enzyme فالفكرة أن التعقيد الموضوع هذا
+
+535
+00:49:19,570 --> 00:49:27,040
+بالنسبة للجين واحد في محل واحد لما نيجي ناخدإن صار
+
+536
+00:49:27,040 --> 00:49:31,780
+عندى أربع احتمالات، أربع Alleles كل واحد إله يعني
+
+537
+00:49:31,780 --> 00:49:37,900
+خاصية معينة نتذكر إنه كل واحد مننا عنده أربع، Two
+
+538
+00:49:37,900 --> 00:49:43,500
+copies of that gene فالتالي الـ One chromosome لو
+
+539
+00:49:43,500 --> 00:49:48,360
+فرضنا هيك و الـ Other chromosome نفس الترتيب Wild
+
+540
+00:49:48,360 --> 00:49:52,660
+type, reduced, absent or increasedراح ألاقي إن
+
+541
+00:49:52,660 --> 00:49:59,340
+وجود إثنين لسه بعقد الموضوع أكتر بيخليني يعني يكون
+
+542
+00:49:59,340 --> 00:50:05,960
+عندي تفاوت بدرجات مش كبسة كهربا on أو off موجود أو
+
+543
+00:50:05,960 --> 00:50:11,080
+مش موجود فعادة الـ Normal الـ Wild-type إذا موجود
+
+544
+00:50:11,080 --> 00:50:15,080
+two copies هو Normal بس الـ Wild-type واحدة كمان
+
+545
+00:50:15,080 --> 00:50:18,860
+Normal لأنه لو هنا أبسط هو إنه Normal، بنلاقيهم
+
+546
+00:50:18,860 --> 00:50:23,210
+Normal هدولة بنلاقيهم Normalلو واحد increased،
+
+547
+00:50:23,210 --> 00:50:30,350
+ultra-fast فلو كانوا اثنين reduced، راح يكون إذا
+
+548
+00:50:30,350 --> 00:50:35,210
+اثنين reduced، راح يكون النتيجة إنه هذا الإنسان
+
+549
+00:50:35,210 --> 00:50:39,390
+poor metabolizer، الـPhenotype تبعه إذا كان واحد
+
+550
+00:50:39,390 --> 00:50:43,410
+reduced، واحد absent، برضه poor إذا اثنينهم
+
+551
+00:50:43,410 --> 00:50:49,430
+absent، برضه poor الـUltra-fast إذا كان increased،
+
+552
+00:50:49,430 --> 00:50:56,020
+مش عارف يعنيممكن يكون الـUltra-Fast أو مثلًا، لا
+
+553
+00:50:56,020 --> 00:51:00,520
+يتحدث بهذا الشكل ممكن الـLethal combination يكون
+
+554
+00:51:00,520 --> 00:51:05,300
+Ultra-Fast أو الـTwo copies أو كذا أو هنا اللي
+
+555
+00:51:05,300 --> 00:51:09,060
+احنا بنتكلمه ممكن إذا واحدة Reduced وواحدة
+
+556
+00:51:09,060 --> 00:51:12,460
+Increased بيطلع Normal يمكن هذا قصده يكون Normal
+
+557
+00:51:12,460 --> 00:51:16,920
+أو واحدة Absent واحدة Increased برضه إنه بيكون
+
+558
+00:51:16,920 --> 00:51:24,000
+Normalفالموضوع أن الـ «متابوليزم الدراجات» هو نقطة
+
+559
+00:51:24,000 --> 00:51:29,480
+مهمة جدًا وهي اللي يجب أن يبلش فيها عادة اللي هم
+
+560
+00:51:29,480 --> 00:51:33,480
+في المستشفيات الكبيرة اللي بيكون زي الأسماء
+
+561
+00:51:33,480 --> 00:51:37,040
+الأدوية اللي حطيناها في الكيماوي في الأمراض
+
+562
+00:51:37,040 --> 00:51:44,040
+الخطيرة وكذا بتكون عندنا Farm D اللي هم اسمهم
+
+563
+00:51:44,040 --> 00:51:49,600
+دكتور سيدلةوظيفته إنه يشيك على الأدوية والـ
+
+564
+00:51:49,600 --> 00:51:53,040
+Metabolism تبع الأدوية وعلاقة الأدوية مع بعض وكذا
+
+565
+00:51:53,040 --> 00:51:58,860
+النقطة الثانية بالنسبة لهذا الموضوع على الـ
+
+566
+00:51:58,860 --> 00:52:04,460
+Increased Metabolizer أو Ultra-Fast Metabolizer أو
+
+567
+00:52:04,460 --> 00:52:08,500
+Poor Metabolizer أو Normal Metabolizer إن نسبة هذه
+
+568
+00:52:08,500 --> 00:52:14,420
+الأشياء متفاوتة بين البشر مش كل البشر زي بعض
+
+569
+00:52:16,600 --> 00:52:20,500
+فمثلًا، الـPacific Islanders اللي هم في الجزر
+
+570
+00:52:20,500 --> 00:52:27,240
+المحيط الهادي مجتمعات معزولة من سنين ولأجيال كثيرة
+
+571
+00:52:27,240 --> 00:52:33,040
+في تركز للجينات بشكل معين نوعية معينة من
+
+572
+00:52:33,040 --> 00:52:37,400
+الـMutation بتلاقيها صفر والنوعية الثانية من أعلى
+
+573
+00:52:37,400 --> 00:52:41,060
+الناس الأفريقيين
+
+574
+00:52:41,580 --> 00:52:47,760
+أو الأمريكان أو من منطقة الشرق الأوسط أننا مثلا
+
+575
+00:52:47,760 --> 00:52:58,300
+نسب معين للمشاكل هذه أو للملاحظات هذه فالآن
+
+576
+00:52:58,300 --> 00:53:07,700
+يعني احنا اتكلمنا عن بالأول اللي هو موضوع الـ
+
+577
+00:53:09,350 --> 00:53:13,250
+اللي هو إنه لازم واحد ياخد تاريخ مرضي عن الـ Colon
+
+578
+00:53:13,250 --> 00:53:19,730
+Cancer خارج المسح الوطني للموليد الجدد وكيف أتعامل
+
+579
+00:53:19,730 --> 00:53:23,110
+معه والمبدأ الثالث في الـ Personalized Medicine
+
+580
+00:53:23,110 --> 00:53:27,410
+اللي هو موضوع الـ Pharmacogenetics والتعامل مع
+
+581
+00:53:27,410 --> 00:53:32,170
+الأدوية وكيفية تأثير الوراثة بشكل أو بآخر على
+
+582
+00:53:32,170 --> 00:53:38,180
+الأدوية من ناحية الأخيرة، لما نتكلم عن الفحوصاتكيف
+
+583
+00:53:38,180 --> 00:53:42,840
+بدي أتعامل معها؟ وكيف بدي أطبّقها؟ وإذا أنا بحتاج
+
+584
+00:53:42,840 --> 00:53:47,800
+أني أعملها؟ اللي هي الـ Genetic Epidemiology يعني
+
+585
+00:53:47,800 --> 00:53:54,620
+علم الطب المجتمع الوراثي أنا بدور على الأمراض
+
+586
+00:53:54,620 --> 00:54:01,220
+الوراثية وبصير أتكلم عن طبعاً بكون عندي فحص معين
+
+587
+00:54:01,220 --> 00:54:06,640
+لإثبات وجود المرضوبدي أتعامل علاقة الـ «جين» أو
+
+588
+00:54:06,640 --> 00:54:13,580
+علاقة الفحص تبعي بوجود المرض والتعامل معه بنقول
+
+589
+00:54:13,580 --> 00:54:18,300
+النقطة الأولى في هذا الموضوع للمعلمة طب المجتمع
+
+590
+00:54:18,300 --> 00:54:26,140
+إنه أنا ممكن يكون عندي ثلاث أنواع من الدراسات
+
+591
+00:54:26,140 --> 00:54:32,830
+أحيانًا أنا استطيع أن أعملبتسموه Case Control
+
+592
+00:54:32,830 --> 00:54:37,290
+Study أو Cross-Sectional Study أو Cohort يعني
+
+593
+00:54:37,290 --> 00:54:42,090
+دراسة بالحالة والمقارنة أو الحالة والمقارنة مع
+
+594
+00:54:42,090 --> 00:54:48,290
+الطبيعي هذه طريقة معينة ويعني إلها إيجابيات وإلها
+
+595
+00:54:48,290 --> 00:54:53,830
+سلبيات، أسهل الطريقة بجيب مثلًا، بدي أدرس الـ Rabo
+
+596
+00:54:53,830 --> 00:54:57,950
+شو تأثير الجين اللي فلاني على الـ Rabo بروح بجيب
+
+597
+00:54:57,950 --> 00:55:02,440
+لـMeet مريض عنده Raboوبروح أفحص الجين هذا تبعه
+
+598
+00:55:02,440 --> 00:55:09,960
+وبعدين بروح باخد مائة إنسان طبيعي مائة إنسان
+
+599
+00:55:09,960 --> 00:55:14,380
+ماعندوش هذا المرض يعني ممكن يكون عنده أمراض ثانية
+
+600
+00:55:14,380 --> 00:55:20,640
+ويكونون بنفس الدرجة بس الأصل إن أخدهم مائة يعني
+
+601
+00:55:20,640 --> 00:55:26,720
+نفس العدد مشابهين من ناحية العمر من ناحية الجنس
+
+602
+00:55:27,040 --> 00:55:30,240
+يعني إذا أخذت كلهم ذكور لازم الـ «control» كلهم
+
+603
+00:55:30,240 --> 00:55:33,420
+ذكور لا يمكنني أن أخذ المرضى ذكور والـ «control»
+
+604
+00:55:33,420 --> 00:55:37,800
+يكفي مثلًا، ماشي فهذه طريقة أسهل طريقة بيسموها
+
+605
+00:55:37,800 --> 00:55:41,400
+«case control» وهي أضعف طريقة بس يمكن هو اللي
+
+606
+00:55:41,400 --> 00:55:45,380
+موجود عندنا وهو اللي بيقدر أنا أسويه الـ «case
+
+607
+00:55:45,380 --> 00:55:49,440
+control» ممكن أنا أشوف يعني ممكن أدور على الـ
+
+608
+00:55:49,440 --> 00:55:53,340
+genotype ممكن أشوف exposure معين والله radiation
+
+609
+00:55:54,260 --> 00:55:56,980
+اللي اتعرضوا للـ Radiation واللي ما اتعرضوش للـ
+
+610
+00:55:56,980 --> 00:56:01,420
+Radiation بصير أقول Case Control Cross-sectional
+
+611
+00:56:01,420 --> 00:56:08,120
+يعني إن أنا آجي مثلًا على مجتمع وأخذ مسحة منه في
+
+612
+00:56:08,120 --> 00:56:17,140
+لحظة معينة وأخذهم كلهم، ماشي؟ مثلًا آجي أقول أنا
+
+613
+00:56:17,140 --> 00:56:25,420
+والله بدي أدرس مثلًاالمرض الفلاني مثلًا نفترض وجود
+
+614
+00:56:25,420 --> 00:56:29,660
+السكري بين طلبتي الجامعة مثلًا نفترض هيك أو إذا
+
+615
+00:56:29,660 --> 00:56:35,260
+بدي مثلًا مجموعة كبار بالعمر أكبر مثلًا أو أطفال
+
+616
+00:56:35,260 --> 00:56:39,480
+في مدرسة في سن معين أو كذا أو كذا ال population
+
+617
+00:56:39,480 --> 00:56:46,970
+اللي أنا بتكلم عنها باجي باخد كل أفرادهاوبأخدهم
+
+618
+00:56:46,970 --> 00:56:54,600
+مسحة كأن المجتمع بيأكملهبأخد منه قصة واحدة في لحظة
+
+619
+00:56:54,600 --> 00:57:02,440
+معينة بأفحص يعني العينات تبعت الـ يعني هنا بأخد
+
+620
+00:57:02,440 --> 00:57:06,980
+عيناة محددة من المجتمع اللي تم إختارها وتقوم
+
+621
+00:57:06,980 --> 00:57:08,560
+بتقليلها إلى أولئك اللي كان لديه المرض ولم يكن
+
+622
+00:57:08,560 --> 00:57:09,960
+لديه المرض وليس لديه المرض وليس لديه المرض وليس
+
+623
+00:57:09,960 --> 00:57:11,500
+لديه المرض وليس لديه المرض وليس لديه المرض وليس
+
+624
+00:57:11,500 --> 00:57:12,100
+لديه المرض وليس لديه المرض وليس لديه المرض وليس
+
+625
+00:57:12,100 --> 00:57:12,660
+لديه المرض وليس لديه المرض وليس لديه المرض وليس
+
+626
+00:57:12,660 --> 00:57:13,140
+لديه المرض وليس لديه المرض وليس لديه المرض وليس
+
+627
+00:57:13,140 --> 00:57:19,780
+لديه المرض وليس لديه المرض وليس
+
+628
+00:57:19,780 --> 00:57:26,640
+لبس في الغالب إذا بدي عدد يعني ممثل يعني في الأراء
+
+629
+00:57:26,640 --> 00:57:30,600
+السياسية حسب تشوفوا بالانتخابات وغيرها وغيرها إذا
+
+630
+00:57:30,600 --> 00:57:38,140
+فعلا بشكل عشوائي وبشكل ممثل للكل مثلا أخدت مثلا في
+
+631
+00:57:38,140 --> 00:57:44,180
+الانتخابات الرئيسية الأمريكية بس تأخد عينة من ألف
+
+632
+00:57:44,180 --> 00:57:49,940
+شخص لحد ما توصل إنك أخدت عينة من ألف شخصالنتيجة
+
+633
+00:57:49,940 --> 00:57:52,960
+راح تكون قريبة للنتيجة الحقيقية اللي راح تطلع في
+
+634
+00:57:52,960 --> 00:57:59,960
+الانتخابات «±3%» أو الـ Error Margin «2%» أو «4%»
+
+635
+00:57:59,960 --> 00:58:05,520
+على بعض «3%» يعني بالنسبة عالية جداً بكون أنا واثق
+
+636
+00:58:05,520 --> 00:58:10,980
+95% أو 96% أو 97% بكون أنا متأكد أن هذه العلاقة
+
+637
+00:58:10,980 --> 00:58:17,830
+موجودة عن طريقالـ Sample اللي ما تكون ممثلة وكبيرة
+
+638
+00:58:17,830 --> 00:58:21,970
+بما فيه الكفاية ما تكون Sample صغيرة لما نكون في
+
+639
+00:58:21,970 --> 00:58:25,210
+أشياء كثيرة بنتكلم عن حدود الألف في القراءة
+
+640
+00:58:25,210 --> 00:58:29,090
+السياسية مثلا بيقدر الواحد فهو جزء من تصميم
+
+641
+00:58:29,090 --> 00:58:35,270
+الدراسة كم عينة اللي بديها النوع الثالث مرات احنا
+
+642
+00:58:35,270 --> 00:58:40,950
+بنعمل Cohort يعني مثلا اللي هي مجموعة
+
+643
+00:58:43,280 --> 00:58:48,560
+مثلًا أنا آجي أقول في بلد مثلًا نقول غزة أنا بدأ
+
+644
+00:58:48,560 --> 00:58:55,920
+أعمل دراسة بتكون على مدى متابعة لمدة مثلًا سنين
+
+645
+00:58:55,920 --> 00:58:59,660
+كثيرة باخد
+
+646
+00:58:59,660 --> 00:59:04,520
+مثلًا cohort موليد مدينة غزة في اليوم مثلًا في
+
+647
+00:59:04,520 --> 00:59:11,320
+اليوم اللي فلاني موليد مثلًا نقول ألف نفترضفخلاص
+
+648
+00:59:11,320 --> 00:59:17,360
+فدول الألف بسوي نظام أني أنا لما يولدوا بفحصهم
+
+649
+00:59:17,360 --> 00:59:23,220
+بشوفهم يعني في دول مثلا كهر في السواد مثلا وليد
+
+650
+00:59:23,220 --> 00:59:28,720
+سنة الواحد وستينبسنة الـ 1961 فحصوهم وبعد سنة
+
+651
+00:59:28,720 --> 00:59:34,360
+فحصوهم وبعد سنتين فحصوهم نفس فريق الدراسة يتابع
+
+652
+00:59:34,360 --> 00:59:38,020
+هذه المجموعة لحد ما تنتهي الدراسة في مدى الحياة
+
+653
+00:59:38,020 --> 00:59:42,620
+يعني ممكن أنا أشوف والله اللي ولدوا في كذا صار
+
+654
+00:59:42,620 --> 00:59:46,080
+فيهم هيك اللي ولد في كذا صار فيهم هيك اللي كان
+
+655
+00:59:46,080 --> 00:59:50,040
+عندهم كذا صار عندهم هيكفهذه بنسميها Cohort هذا
+
+656
+00:59:50,040 --> 00:59:53,880
+نمضان ثالث من الدراسة على المدى الطويل على المدى
+
+657
+00:59:53,880 --> 00:59:58,600
+البعيد فدولة الاستراتيجيات المعتمدة فدولة اللي
+
+658
+00:59:58,600 --> 01:00:03,100
+ممكن نستخدمهم وبيكون واحد فاهمهم لما نقرأ تقريغ
+
+659
+01:00:03,100 --> 01:00:08,200
+طبي يعني والله الـ Cohort تبعت فحص الأزمة في الـ
+
+660
+01:00:08,200 --> 01:00:12,360
+Inner City في نيويورك مثلا في محل معين بدي أفهم
+
+661
+01:00:12,360 --> 01:00:18,530
+أكون فاهم أنها Cohort يعني مجموعة من الأولأخدوهم
+
+662
+01:00:18,530 --> 01:00:23,790
+وظلهم يتابعوا فيهم ويلاحقوهم وطبعا مع مرور الوقت
+
+663
+01:00:23,790 --> 01:00:30,690
+بتلاقي يعني ممكن أول سنة تسعين بالمية نلاقيهم نخسر
+
+664
+01:00:30,690 --> 01:00:35,690
+عشرة بالمية مثلا يعني والله مية ونهاية السنة كدرتش
+
+665
+01:00:35,690 --> 01:00:40,830
+إذا واحد بيقولك أول سنة أول مرة جبت مية يعني ركيت
+
+666
+01:00:40,830 --> 01:00:47,910
+المية شخص وتعاملت معهموبعد سنة أو عشر سنين وصلت
+
+667
+01:00:47,910 --> 01:00:53,250
+المية تماماً، بقولك مستحيل إلا يكون واحد مات، واحد
+
+668
+01:00:53,250 --> 01:00:57,690
+انتقل، واحد بطل يحب يشارك في الدراسة، وواحد فيه
+
+669
+01:00:57,690 --> 01:01:02,790
+عنده مشكلة، فمرات كثيرة بد الواحد ينتبه، فذولا
+
+670
+01:01:02,790 --> 01:01:09,950
+الستراتيجيات النقطة الآن، في أسئلة، يا دكتور أحمد
+
+671
+01:01:09,950 --> 01:01:16,540
+أو غيره، في حد عنده سؤالهي كان سؤال من كريم بخصوص
+
+672
+01:01:16,540 --> 01:01:21,260
+الجدول اللي كان قبل الـ «سلايد» السابق «الألترا
+
+673
+01:01:21,260 --> 01:01:25,720
+فاست» مش عارف قصده نسخة واحدة كافية يكون هي قصد
+
+674
+01:01:25,720 --> 01:01:30,880
+الجدول؟ آه هي قصد الجدول كانت إنه إذا واحدة Ultra
+
+675
+01:01:30,880 --> 01:01:37,920
+Fast شكلها كافية لهذا الأليل لهذا النوع من
+
+676
+01:01:37,920 --> 01:01:41,860
+الإنزيمات طبعاً بيكون في الغالب درسوه على دوة
+
+677
+01:01:41,860 --> 01:01:47,150
+معينةفاهم عليك كيف؟ فمرات، أه، بتكون، وطبعًا إذا
+
+678
+01:01:47,150 --> 01:01:52,310
+كانت سنتين ultra-fast يمكن يعني حاطين شحطة يعني مش
+
+679
+01:01:52,310 --> 01:01:56,650
+كاتبين إنه فيه بتصير حالات منها بس أه، بتكون سريع
+
+680
+01:01:56,650 --> 01:02:01,410
+جدًا يعني فبالتالي، بدك إذا عرفت إنه ultra-fast
+
+681
+01:02:01,410 --> 01:02:06,010
+وعطيته الدواء، ما راح يفيدك ما راح تحصل الاستجابة
+
+682
+01:02:06,010 --> 01:02:08,970
+المطلوبة لأنك أصلا ماوصلت للجرعة اللازمة بدك
+
+683
+01:02:08,970 --> 01:02:11,250
+تزودها يعني إذا عرفت، أه
+
+684
+01:02:15,520 --> 01:02:21,920
+الآن هذا جدول أنا بعتبره من أهم الجداول وحقيقة
+
+685
+01:02:21,920 --> 01:02:31,360
+يعني الواحد أنه بيفهمه لازم يعني ضروري لأي دكتور
+
+686
+01:02:31,360 --> 01:02:35,200
+لأنه لما الواحد يقرأ المقالات الإلمية يجب أن يكون
+
+687
+01:02:35,200 --> 01:02:40,020
+منتبه للنقطة هذه لما
+
+688
+01:02:40,020 --> 01:02:46,830
+نحن نتكلم مافيش إشي في الدنيا لازمحقيقي مية بالمية
+
+689
+01:02:46,830 --> 01:02:52,830
+مافيش إشي يعني أي في الـ MCQ's always and never
+
+690
+01:02:52,830 --> 01:02:57,910
+and always wrong مافيش إشي never مافيش إشي always،
+
+691
+01:02:57,910 --> 01:03:06,150
+ماشي؟ فلو جيت أنا أفرض أن أعمل تجربة وجبت مثلا
+
+692
+01:03:06,150 --> 01:03:12,410
+مجموعة معينة هو أنا الدراسة بيحكون عنها أنه بالأخر
+
+693
+01:03:12,410 --> 01:03:20,300
+Nالـ N هي العدد الكلي باجي بشوف، بكون عندي Gold
+
+694
+01:03:20,300 --> 01:03:24,700
+Standard بكون عندي طريقة أو أسلوب عشان أعرف المرض
+
+695
+01:03:24,700 --> 01:03:30,440
+موجود ولا مش موجود فبقسم الناس، في ناس عندهم المرض
+
+696
+01:03:30,440 --> 01:03:35,820
+وفي ناس ماعندهم مش المرض اللي عندهم المرض بالأخير
+
+697
+01:03:35,820 --> 01:03:39,540
+راح يقسموا Total Affected راح يكون الـ A زاد C
+
+698
+01:03:40,330 --> 01:03:45,190
+واللي ما عندهم مش المرض «unaffected» «BND» حيث أنه
+
+699
+01:03:45,190 --> 01:03:51,990
+المجموع الكل بيساوي «N» أي فحص عادةً ما بيكون إلا
+
+700
+01:03:51,990 --> 01:03:56,890
+100% كل اللي عندهم مرض لازم يصير عندهم الفحص يطلع
+
+701
+01:03:56,890 --> 01:04:02,630
+إيجابي، ما بيطلع هيك يعني لو حتى 99% ممتاز جداً
+
+702
+01:04:02,630 --> 01:04:11,770
+جداً جداً إذا لو 99% بيظل 1% بيطلع، مش هيكفلما
+
+703
+01:04:11,770 --> 01:04:17,510
+أدرس فحص معين والمثال هنا بالذات لـ Genotype معين
+
+704
+01:04:17,510 --> 01:04:22,450
+يعني بفحص أنا على وجود Gen محدد بالشكل هذا فإذا
+
+705
+01:04:22,450 --> 01:04:26,850
+الأليل بالشكل اللي أنا بظن أنه إله دخل فهذا بقول
+
+706
+01:04:26,850 --> 01:04:29,890
+هو الـ Susceptibility Genotype وبقول هو أنا طلعت
+
+707
+01:04:29,890 --> 01:04:34,870
+Positive أو Present حسب الـ Test راح يكون في
+
+708
+01:04:34,870 --> 01:04:38,370
+مجموعة ثانية Susceptibility Group Test Absent
+
+709
+01:04:39,710 --> 01:04:46,610
+الدنيا هيك فنتيجة الأمر هذا أنه فيه راح ينقسم عنده
+
+710
+01:04:46,610 --> 01:04:52,050
+الـ affected راح يصيروا A ال test طلعهم positive و
+
+711
+01:04:52,050 --> 01:04:57,130
+C ال test طلعهم negative واللي عندهم ماعندهم مش
+
+712
+01:04:57,130 --> 01:05:03,300
+المرض ال test لل B طلعهم positive راح يصير هيكوالـ
+
+713
+01:05:03,300 --> 01:05:09,440
+Negative اللي يكون المفروض الغالب يطلعهم الـ Test
+
+714
+01:05:09,440 --> 01:05:15,940
+Negative بس مجموعهم بهذا الشكل وهنا المجموع الفرقي
+
+715
+01:05:15,940 --> 01:05:20,380
+للـ Positive Test اللي هم الـ A والـ B True
+
+716
+01:05:20,380 --> 01:05:28,020
+Positive وFalse Positive والـ C الـ False Negative
+
+717
+01:05:28,020 --> 01:05:34,950
+وFalse Positiveالـ C الـ False Negative والـ D هم
+
+718
+01:05:34,950 --> 01:05:41,590
+الـ True Negative فذولا المجموع بساول N لو أخدت
+
+719
+01:05:41,590 --> 01:05:48,650
+هذا الجدول لعلاقة الـ Test بالـ Disease بقدر أتكلم
+
+720
+01:05:48,650 --> 01:05:55,190
+على النقاط اللي بعدها فذولا نقاط مهم كثير كل واحد
+
+721
+01:05:55,190 --> 01:06:00,910
+منهم راح أجيبلكم إياها في الامتحانماشي، وما دخلناش
+
+722
+01:06:00,910 --> 01:06:05,350
+100% بالـ Genetics بقدر ما أنه هنا حتى نتكلم عن
+
+723
+01:06:05,350 --> 01:06:11,910
+الـ Statistics والإحصاء والـ Epidemiology طب
+
+724
+01:06:11,910 --> 01:06:15,710
+المجتمع فالنقاط
+
+725
+01:06:15,710 --> 01:06:18,410
+التعريفات هذه مهمة كثير الـ Frequency of
+
+726
+01:06:18,410 --> 01:06:23,210
+Susceptibility of Genes اللي هم الـ A والـ B على
+
+727
+01:06:23,210 --> 01:06:30,860
+الـ M يعني كام نسبة الناس طلعواPositive، أيوة يا
+
+728
+01:06:30,860 --> 01:06:35,000
+كريم ممكن تحيط دكتور رجستر الـ Positive والـ
+
+729
+01:06:35,000 --> 01:06:41,140
+Negative فوق في الجدولة؟ شوف، أنا افرض عندي مرض،
+
+730
+01:06:41,140 --> 01:06:49,820
+ماشي؟ وعندي test أنا بعرف أني أنا بستخدمه يعني راح
+
+731
+01:06:49,820 --> 01:06:55,820
+ناخد أمثلة عليهم، ماشي؟ فالـ Test لما نكون إنسان
+
+732
+01:06:55,820 --> 01:07:02,730
+مصابلو فرضنا قوة هذا الـ Test 99%، ماذا سيحصل؟
+
+733
+01:07:02,730 --> 01:07:09,270
+سيحصل أن البشر اللي بفحصهم 99%، المية الذولة اللي
+
+734
+01:07:09,270 --> 01:07:12,290
+بفحصهم أنهم كانوا Positive، كان عندهم المرض
+
+735
+01:07:12,290 --> 01:07:17,850
+الغالبية العظمة يفترض أنه سيحصل عندهم Positive بس
+
+736
+01:07:17,850 --> 01:07:23,750
+بظل جزء بسيط منهم بتبين معاهم الـ Test Negative،
+
+737
+01:07:23,750 --> 01:07:29,170
+ولو أنه عنده المرضيعني أنا مثلًا مرات حتى تفهموا
+
+738
+01:07:29,170 --> 01:07:34,470
+العلاقات بين الأشياء مثلًا بأجي بقول أنا بفحص مرض
+
+739
+01:07:34,470 --> 01:07:42,070
+السكري عن طريق يعني بنشخص احنا مرض السكري عن طريق
+
+740
+01:07:42,070 --> 01:07:50,610
+فحص سكر الدم، لما أنا أجيلما أقول، وإيها دخل في
+
+741
+01:07:50,610 --> 01:07:55,070
+التعريف لأن إيها دخل بعدين بالـ Sensitivity والـ
+
+742
+01:07:55,070 --> 01:07:59,750
+Specificity اللي سنحكي عنهم لما أقول أنا والله
+
+743
+01:07:59,750 --> 01:08:04,890
+اللي باخد أنا كتعريف السكري الإنسان اللي سكريه
+
+744
+01:08:04,890 --> 01:08:10,710
+طبيعي اللي هو تحت 126 ميلي جرام per deciliter هذا
+
+745
+01:08:10,710 --> 01:08:16,010
+بعتبره إنسان طبيعيواللي فوق 126 أو 141 حسب
+
+746
+01:08:16,010 --> 01:08:21,130
+التعريفات للمرض السكري بعتبر إن هذا عنده سكري
+
+747
+01:08:21,130 --> 01:08:25,550
+وبقول هذا عنده المرض فإحنا هنا أخذنا قراءة رقم
+
+748
+01:08:25,550 --> 01:08:32,630
+السكر كـ Test للسكري، صح؟ ماشي معاه يا كريم؟ معاك
+
+749
+01:08:32,630 --> 01:08:37,410
+سيد الدكتور طيب، افرض مريض سكري أجى يوم الفحص لسبب
+
+750
+01:08:37,410 --> 01:08:44,540
+ما زبط معاهما أكلش بالليل، ارتبك، عمل رياضة، اشتغل
+
+751
+01:08:44,540 --> 01:08:49,220
+يحلف بالأرض، وظبط السكري معاه، وثاني يوم هو مريض
+
+752
+01:08:49,220 --> 01:08:54,160
+سكري، هو بشكي، بعطشان، وببول، وبشرب ميه كتير،
+
+753
+01:08:54,160 --> 01:08:58,440
+وتعبان، ومرهق، وكذا، هو فعلا عنده سكري لو فحصته
+
+754
+01:08:58,440 --> 01:09:01,900
+بالـHemoglobin A1C، بس يوم ما راح يعمل الفحص
+
+755
+01:09:01,900 --> 01:09:07,880
+…‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏
+
+756
+01:09:10,280 --> 01:09:16,060
+صحيح هذا جزء منه بس الفكرة أنه لو أخدت مثال أنا
+
+757
+01:09:16,060 --> 01:09:21,380
+عشان أشرح المثال اللي حاطينهإنه بيقول مرضى السكري
+
+758
+01:09:21,380 --> 01:09:24,060
+أنا عنده الـGold Standard بالـHemoglobin A1C
+
+759
+01:09:24,060 --> 01:09:28,340
+وبعيده مرتين عشان أتأكد وعندي أسلوب وكذا وكذا بس
+
+760
+01:09:28,340 --> 01:09:32,440
+افرض إن أنا هيك جيت على عشرة جاعدين أو عشرين
+
+761
+01:09:32,440 --> 01:09:35,580
+جاعدين مرضى السكري قتياري وكلهم أنا عارف هم عندهم
+
+762
+01:09:35,580 --> 01:09:40,080
+زكري وجيت أقول بدي أعمل فحص السكر هذا طريقة جديدة
+
+763
+01:09:40,080 --> 01:09:45,240
+عشان أشوف ولا طريقة عشان أشوفرح يصير أنه مثلًا
+
+764
+01:09:45,240 --> 01:09:49,060
+الغالبية العظمة اللي عندهم سكري بتوقع أنه راح يطلع
+
+765
+01:09:49,060 --> 01:09:55,940
+لأنه Normal Distribution اللي هو التوزيع
+
+766
+01:09:55,940 --> 01:09:59,680
+الطبيعي للأشياء فراح يظل فيه جزء من اللي عندهم
+
+767
+01:09:59,680 --> 01:10:04,620
+سكري يوم ما أنت تفحص وراح يطلع Normal فهذا راح
+
+768
+01:10:04,620 --> 01:10:12,610
+يكون False Negative فهم علي؟ اللي هو الـDأسف اللي
+
+769
+01:10:12,610 --> 01:10:17,990
+هو الـ C اللي هو إنه إنسان affected بس ال test
+
+770
+01:10:17,990 --> 01:10:22,310
+بهاي لحظة ما طلع ليها positive فاهم عليك كيف؟
+
+771
+01:10:22,310 --> 01:10:29,870
+فهدولة ال A true positive ال D true negative ال C
+
+772
+01:10:29,870 --> 01:10:34,730
+لأنه هو affected بس ال test طلع ليها negative فهو
+
+773
+01:10:34,730 --> 01:10:39,070
+false negative هذا إنسان false negative ومصاب بس
+
+774
+01:10:39,070 --> 01:10:44,550
+ما طلع ليها ال testوالـ B هو الـ False Positive هو
+
+775
+01:10:44,550 --> 01:10:50,050
+إنسان مش مصاب بس واحد مثلا أكل كثير بهالليل قبل ما
+
+776
+01:10:50,050 --> 01:10:54,690
+يروح يعمل الفحص ماكانش صايم مظبوط صار عنده stress
+
+777
+01:10:54,690 --> 01:11:00,930
+والهرمون كان عالي عنده ارتفاع السكري فدايماً هدولة
+
+778
+01:11:00,930 --> 01:11:07,200
+يعني إحنا بنقسم الناس بالنسبة للمرض وللـ TestTrue
+
+779
+01:11:07,200 --> 01:11:10,540
+Positive وTrue Negative وFalse Positive وFalse
+
+780
+01:11:10,540 --> 01:11:15,100
+Negative، وهكذا تكون الدنيا عندما نقول إنه في عندي
+
+781
+01:11:15,100 --> 01:11:19,620
+Susceptibility Genotype هو الـ A زائد B على الـ N
+
+782
+01:11:19,620 --> 01:11:27,370
+نسبة الـ Positives، يعني بقول إنهلما أنتيجة أحسب
+
+783
+01:11:27,370 --> 01:11:32,630
+فداش نسبة الـ test positive عند المرض الـ test
+
+784
+01:11:32,630 --> 01:11:35,850
+positive الـ true positive و الـ false positive
+
+785
+01:11:35,850 --> 01:11:39,670
+بأخدهم فبأخد الـ A والـ B على الـ N هاي الـ
+
+786
+01:11:39,670 --> 01:11:43,990
+frequency of the susceptibility الجينotype نحسبها
+
+787
+01:11:43,990 --> 01:11:48,490
+هي الـ disease prevalence شو احتمالية وجود المرض
+
+788
+01:11:48,490 --> 01:11:54,290
+اللي هو A زات C على الـ N ماشي؟فيه شيء اسمه الـ
+
+789
+01:11:54,290 --> 01:11:59,270
+Relative Risk Ratio اللي هو بالشكل هذا المعادلات
+
+790
+01:11:59,270 --> 01:12:03,630
+هذه مهمة Disease prevalence in carriers of
+
+791
+01:12:03,630 --> 01:12:06,950
+susceptibility genotype على Disease prevalence in
+
+792
+01:12:06,950 --> 01:12:12,690
+non-carriers of susceptibility genotype فبتكون هذه
+
+793
+01:12:12,690 --> 01:12:17,410
+Relative Risk Ratio بهذه الطريقة المهم كتير
+
+794
+01:12:17,410 --> 01:12:22,890
+بنسمعها Sensitivity وSpecificity Sensitivityهو
+
+795
+01:12:22,890 --> 01:12:27,310
+قدّاش Positive من اللي عنده المرض فاللي عنده المرض
+
+796
+01:12:27,310 --> 01:12:34,630
+A زي C اللي Test طلّعهم Positive الـ A فالـ A على
+
+797
+01:12:34,630 --> 01:12:41,050
+الـ A زي C هي Sensitivity وSpecificity للعكس، شو
+
+798
+01:12:41,050 --> 01:12:47,530
+نثبت أنه اللي Test طلّعهم Negative يكونوا فعلاً
+
+799
+01:12:47,530 --> 01:12:55,190
+True Negative مش False Negativeفنسبة الـ D على الـ
+
+800
+01:12:55,190 --> 01:12:59,570
+BND اللي هو الـ Unaffected وفيه الـ Positive
+
+801
+01:12:59,570 --> 01:13:02,930
+Predictive Value فهي معدلتها والـ Negative
+
+802
+01:13:02,930 --> 01:13:07,470
+Predictive Value طلع عليهم، اقرؤوهم، مهم كثير
+
+803
+01:13:07,470 --> 01:13:11,870
+وجوانب مهمة النقطة الأساسية اللي يعني اللي واحد
+
+804
+01:13:11,870 --> 01:13:17,110
+بدي يفهمها ليه إنه الـ Sensitivity وSpecificity
+
+805
+01:13:17,110 --> 01:13:25,550
+تناسبهم عكسي يعنيأنا مثلًا الـ Diagnostic Cut-off
+
+806
+01:13:25,550 --> 01:13:32,310
+Level للديابتس 126 milligram per deciliter رقم
+
+807
+01:13:32,310 --> 01:13:36,630
+معين بدي أحطه هو الـ Cut-off أشان أقول أعلى منه
+
+808
+01:13:36,630 --> 01:13:40,550
+عنده سكري أو أعطى منه ما عنده السكري ففي الحالة
+
+809
+01:13:40,550 --> 01:13:50,290
+هذه لو أنا قلت بدي أخلي الرقم هذا 140 141 الأن
+
+810
+01:13:50,650 --> 01:13:58,170
+في حالة الـ 141 شو استفدت؟ استفدت إن اللي ما عندهم
+
+811
+01:13:58,170 --> 01:14:05,470
+مش سكري ولسبب ما وصل الـ 126 نادر أقل حدوثا أنه
+
+812
+01:14:05,470 --> 01:14:09,870
+وصل الـ 140 فأنا بزود الـ Sensitivity تبع الـ Test
+
+813
+01:14:09,870 --> 01:14:14,130
+في مقابل إنه بقلل الـ Sensitivityبزيد الـ
+
+814
+01:14:14,130 --> 01:14:17,190
+Specificity، راح أقلل الـ Sensitivity، والعكس
+
+815
+01:14:17,190 --> 01:14:22,510
+بالعكس وبتطلع عليها وشغل مفهوم يعني إن شاء الله بس
+
+816
+01:14:22,510 --> 01:14:27,170
+الأهم يعني هدولة الخمس الـ Definitions أو ست الـ
+
+817
+01:14:27,170 --> 01:14:34,670
+Definitions هدولة مهمات كثير وابصموهم بصمي لما
+
+818
+01:14:34,670 --> 01:14:38,790
+ناخد مثال على هذا الموضوع أنا بأجي مثلا الـ Colon
+
+819
+01:14:38,790 --> 01:14:42,980
+Cancerالـ Colon Cancer بشخصه مثلاً إن أعمل
+
+820
+01:14:42,980 --> 01:14:47,740
+colonoscopy و أروح أدور جوا و أتطلع على القلون تبع
+
+821
+01:14:47,740 --> 01:14:51,460
+الإنسان هذا وهنا بأعطوك إنه عملوا الدراسة هذه
+
+822
+01:14:51,460 --> 01:14:57,420
+عوالي 4500 بني آدم يعني عملوا colonoscopy و دوروا
+
+823
+01:14:57,420 --> 01:15:04,160
+مظبوط و اتأكدوا مين affected طلع من الـ 4500 طلعوا
+
+824
+01:15:04,160 --> 01:15:09,340
+45 واحد يعني واحد بالمية طلعت، ممكن أكبر بالعمر
+
+825
+01:15:09,960 --> 01:15:16,680
+وطلعت هالجدّة الـ Positive الـ Negative أربع تلاف
+
+826
+01:15:16,680 --> 01:15:20,960
+وأربع مية وخمسين هدولة الـ Negative البقية لكل
+
+827
+01:15:20,960 --> 01:15:24,620
+أربع تلاف وخمسمية تقريبًا من المجموعتين هذا يعني
+
+828
+01:15:24,620 --> 01:15:28,740
+هنا واحد بالمية وهنا تقريبًا تسعة وتسعين بالمية
+
+829
+01:15:28,740 --> 01:15:35,500
+فبنقعد أشوف الـ Test شو عمل اللي أنا بدرس على اللي
+
+830
+01:15:35,500 --> 01:15:44,260
+هو يعني قليل معينوبكون في موقع معين 1307 مثلًا بين
+
+831
+01:15:44,260 --> 01:15:52,700
+Lycine وIsoleucine بين أليلين نتاج بلاقيها بهذا
+
+832
+01:15:52,700 --> 01:15:57,060
+الشكل أنا باعتبر الـSusceptibility gene اللي هو
+
+833
+01:15:57,060 --> 01:16:03,720
+Lycine 1307 لأ الـSusceptibility gene اللي هو
+
+834
+01:16:03,720 --> 01:16:11,340
+Isoleucine بهذا الشكللما أجي، أنا أشوف الـ
+
+835
+01:16:11,340 --> 01:16:17,940
+Relative Risk Ratio للقليل اللي هو التبع ABC اللي
+
+836
+01:16:17,940 --> 01:16:21,580
+هو يعني نوع من، يعني هذا هو الجين الأقوى والأهم
+
+837
+01:16:21,580 --> 01:16:28,540
+للتشخيص فلما أشوف الـ Relative Risk Ratio RRR
+
+838
+01:16:28,540 --> 01:16:34,300
+نقراها كثير، نحسبها من الأرقام هذه تطلع 2.4 يعني
+
+839
+01:16:34,300 --> 01:16:38,820
+مرتين ونص، إذا عندك هذا الإشي بتكونأي احتماليتك
+
+840
+01:16:38,820 --> 01:16:47,620
+أكتر إنك يكون عندك المرض الـ Sensitivity
+
+841
+01:16:47,620 --> 01:16:55,280
+16% الـ Specificity 93% الـ Positive Predictive
+
+842
+01:16:55,280 --> 01:17:01,500
+Value 2% الـ Negative Predictive Value 99% هاي
+
+843
+01:17:01,500 --> 01:17:05,720
+أرقام النقطة
+
+844
+01:17:05,720 --> 01:17:11,020
+هذهيعني اللي
+
+845
+01:17:11,020 --> 01:17:20,240
+بدنا نتكلم عليها اللي هي حقيقة إنه يعني هنا بنتكلم
+
+846
+01:17:20,240 --> 01:17:25,740
+عن إحصاء بنتكلم عن معلومات محددة على مثال محدد بس
+
+847
+01:17:25,740 --> 01:17:30,180
+المبدأ يعني النقطة الأولى اللي هي إنه الـ
+
+848
+01:17:30,180 --> 01:17:34,200
+sensitivity و specificity علاقتهم مع بعض عكسية
+
+849
+01:17:35,490 --> 01:17:39,270
+الناحية الثانية المهمة أحيانًا يعني أنا مثلًا بضرب
+
+850
+01:17:39,270 --> 01:17:46,690
+لكم مثال يعني نستخدمه سريريا حتى إنه إذا أنا عندي
+
+851
+01:17:46,690 --> 01:17:54,650
+حالة وعندي مرض وعندي شغل معين ممكن إني أكون يعني
+
+852
+01:17:54,650 --> 01:18:02,190
+زي ما بقولوا الـ وين أهميتها تعتمد على قداش المرض
+
+853
+01:18:02,190 --> 01:18:07,010
+موجود ضمن ال population هذهاللي هي الـ Prevalence
+
+854
+01:18:07,010 --> 01:18:13,470
+كل مكان نادر جداً ماشي اللي بيصير قيمة الـ False
+
+855
+01:18:13,470 --> 01:18:17,190
+Positive يعني شخص مش مصاب اللي هو الغربي العظمى
+
+856
+01:18:17,190 --> 01:18:21,630
+بيصير دورها أكبر وهنا يعني حاطينك مثال الـ
+
+857
+01:18:21,630 --> 01:18:25,910
+Positive Predictive Value Very Poor 8% بس الـ
+
+858
+01:18:25,910 --> 01:18:31,470
+Negative Predictive Value هي المهمة 99% يعني شو؟
+
+859
+01:18:31,470 --> 01:18:36,580
+يعني مثلاًيعني مثال مشهور جداً ولازم الناس تعرفه
+
+860
+01:18:36,580 --> 01:18:41,720
+اللي عندهم جلطات بالأوردة من الفحوصات إذا ما فيه
+
+861
+01:18:41,720 --> 01:18:46,280
+جلطة بيصير Clotting والـ Clotting فيه Fibrin الـ
+
+862
+01:18:46,280 --> 01:18:50,440
+Fibrin بتم تحطيمه ففيه بيسموه Fibrin Degradation
+
+863
+01:18:50,440 --> 01:18:57,180
+Product، ماشي؟ هذولة، ماشي عند الجلطة بيكون مرتفعة
+
+864
+01:18:57,180 --> 01:19:01,620
+كثير بس في أشياء كثيرة برضه بترفعه وبالتالي قيمته
+
+865
+01:19:02,300 --> 01:19:07,840
+في حالة ما أنه positive مالوش قيمة كثير بس اللي
+
+866
+01:19:07,840 --> 01:19:14,980
+ماعندهوش جلطة ماشي اللي ماعندهوش جلطة بتلاقي الـ
+
+867
+01:19:14,980 --> 01:19:21,860
+يعني الـ الـ إن الـ D-Dimer هذا بتلاقيه negative
+
+868
+01:19:21,860 --> 01:19:28,770
+فاحنا يعني دائما بنقول للمقيمين والدكاترةإنه دور
+
+869
+01:19:28,770 --> 01:19:32,210
+لما تعمل الـ D-Dimer مش تدوره عشان تثبت إنه هي
+
+870
+01:19:32,210 --> 01:19:36,750
+جلطة أنت بتعمله عشان يعني واحد عنده مثلا فشل كلوي
+
+871
+01:19:36,750 --> 01:19:41,910
+الـ D-Dimer راح يظل مرتفع، ماشي بس أنا بتكلم على
+
+872
+01:19:41,910 --> 01:19:47,930
+إنه اللي ما عندهم مش المرض راح تلاقي نسبة اللي
+
+873
+01:19:47,930 --> 01:19:53,290
+عندهم مرتفعة متدنية جدا فبالتالي أحياناً المهم من
+
+874
+01:19:53,290 --> 01:19:56,110
+الفحص اللي هو الـ Negative Predictive Value فهي
+
+875
+01:19:56,110 --> 01:20:00,640
+بتكون هي المهمةهذا الموضوع ممكن ندخله كمان على
+
+876
+01:20:00,640 --> 01:20:12,720
+أكثر من جين مشترك فهنا تنظير نظري عن الـ Relative
+
+877
+01:20:12,720 --> 01:20:18,100
+Risk لثلاث جينات مع الـ Disease Frequency فإذا فيه
+
+878
+01:20:18,100 --> 01:20:22,400
+combination من ثلاثة الـ Relative Risk مثلاً نسبة
+
+879
+01:20:22,400 --> 01:20:26,420
+عالية جداً، 50% من الـ Population بينما لما نكون
+
+880
+01:20:26,420 --> 01:20:29,320
+الثلاثة Negativeالـ Relative risk is very-very
+
+881
+01:20:29,320 --> 01:20:39,460
+weak اللي هي 0.05% يعني خمسة بالألف الفكرة مثلا،
+
+882
+01:20:39,460 --> 01:20:45,060
+أنا باجي يعني ليه بدي أفرقها بين أهمية الفحص كـ
+
+883
+01:20:45,060 --> 01:20:49,140
+Screening لـ Population و لـ Diagnostic Test هون
+
+884
+01:20:49,140 --> 01:20:54,700
+أحطي مثال اللي هو الأبو شيء معين بدرسوه في حالة
+
+885
+01:20:54,700 --> 01:20:59,920
+الـ Alzheimerفأنا، يعني أنا عندي هذا الـ Test
+
+886
+01:20:59,920 --> 01:21:05,940
+ودخلناه في غزة وبستطيع إن أنا أستخدمه إذا بروح
+
+887
+01:21:05,940 --> 01:21:10,240
+أعمل فيه Population Screening يعني باجي عن جنب
+
+888
+01:21:10,240 --> 01:21:15,380
+وطرف كل اللي أعمارهم من 65 إلى 74 سنة باجي بفحصهم
+
+889
+01:21:15,380 --> 01:21:20,680
+إذا كان الـ Prevalence للـ Population للـ
+
+890
+01:21:20,680 --> 01:21:30,870
+Alzheimer Disease 3%النتيجة أن قيمة الفحص سيئة لدي
+
+891
+01:21:30,870 --> 01:21:35,590
+لأن المرض ليس متواجدًا وغالبًا اللي سيصبح Positive
+
+892
+01:21:35,590 --> 01:21:41,130
+الـ Positive Predictive Value ستكون 6% وإذا كان
+
+893
+01:21:41,130 --> 01:21:43,650
+شيء آخر 23%، فهو نسبة قليلة
+
+894
+01:21:47,090 --> 01:21:51,530
+فالأهمية الموضوع هذا أنه أمتى هل عندي إشي أنا ..
+
+895
+01:21:51,530 --> 01:21:55,190
+يعني يمكن هيقبلها لو كان أنا بقدر أسوي إشي بس هذه
+
+896
+01:21:55,190 --> 01:22:00,790
+الحالة وهذه المرض وهذه الإشي عادة ما عندي أني أنا
+
+897
+01:22:00,790 --> 01:22:07,850
+أعمله إشي وأفيده طبعا الـ False Positive اللي
+
+898
+01:22:07,850 --> 01:22:12,390
+ماعندوش مرض وطلعت test عنده positive راح يدخل في
+
+899
+01:22:12,390 --> 01:22:19,700
+قلمنفسي وقلم، يعني أنا بكربه بسويله كرب، بسويله
+
+900
+01:22:19,700 --> 01:22:25,420
+مرض أنه أكون أقول له أنه «انت ال test طالع عندك
+
+901
+01:22:25,420 --> 01:22:28,820
+positive و الله خلينا نعمل فحص أكثر» أو «يمكن أنك
+
+902
+01:22:28,820 --> 01:22:32,520
+تكون معرض للشغل هذه بعدين» أو «يمكن أوتره، يمكن
+
+903
+01:22:32,520 --> 01:22:38,820
+أمرضه» والناحية الثانية أنه ال test بهذا الشكل راح
+
+904
+01:22:38,820 --> 01:22:43,120
+يكون لما يواحد يطلع negative ما هو مالوش قيم كثير،
+
+905
+01:22:43,120 --> 01:22:47,690
+لأنه أصلاًالمرض مش كثير، بس هذا الـ test مش كويس
+
+906
+01:22:47,690 --> 01:22:52,430
+فهو بيصير false reassurance اللي بيطلعوا negative
+
+907
+01:22:52,430 --> 01:22:57,390
+فهي لما نكون أنا استخدمت هذا الفحص اللي هو مش
+
+908
+01:22:57,390 --> 01:23:03,850
+مناسب ك screening test لل population ال screening
+
+909
+01:23:03,850 --> 01:23:12,560
+test بنحاول يكون sensitive ال .. ال ..الثاني الـ
+
+910
+01:23:12,560 --> 01:23:15,520
+Diagnostic Test اللي بيثبت المرض لازم يكون
+
+911
+01:23:15,520 --> 01:23:24,700
+Specific يعني لو جيت أنا على حالة ثانية نفس الـ
+
+912
+01:23:24,700 --> 01:23:32,400
+Test الأب وهذا وجيت طبقته على المجموعة اللي من 65
+
+913
+01:23:32,400 --> 01:23:39,110
+لـ 74 بس عندهم عراضي الخرف الـ Dementiaهذه مجموعة
+
+914
+01:23:39,110 --> 01:23:42,910
+مصابة مثلًا مثلًا مدينة جنكول تعمل تجارب الـ HIV
+
+915
+01:23:42,910 --> 01:23:48,170
+لكل الناس طب ما الـ HIV مرتفعة جدًا وأجي أنا أعمله
+
+916
+01:23:48,170 --> 01:23:51,370
+راح يطلع غالبيت اللي بطلع positive راح يكونوا أصلا
+
+917
+01:23:51,370 --> 01:23:55,350
+هم negative وهي false positive فرح أنا أكرب الناس
+
+918
+01:23:55,350 --> 01:23:59,150
+وأشغلهم وكذا وكذا وبالأخير مايستفيدوش ويكون فيها
+
+919
+01:23:59,150 --> 01:24:03,310
+مشاكل هنا مثلًا روحت على مجموعة المساجين في السجن
+
+920
+01:24:03,310 --> 01:24:08,080
+والله ال incidents يمكن تكون أعلىبعضهم اتناول
+
+921
+01:24:08,080 --> 01:24:12,620
+مخدرات بعضهم عمل مشاكل سلوك وغير سوي أو اللي هو
+
+922
+01:24:12,620 --> 01:24:16,780
+كذا وعرضهم للشغل فمن أعمل الـ Test وقتها حتى لو
+
+923
+01:24:16,780 --> 01:24:21,120
+كان مش 100% طبعاً ومش راح يكون فيه إشي مش 100%
+
+924
+01:24:21,120 --> 01:24:26,160
+فهتكون أفضل بكتير ففي الحال الثاني هذه راح نلاقي
+
+925
+01:24:26,160 --> 01:24:31,120
+إنه الـ Positive Predictive Value 75% الـ Negative
+
+926
+01:24:31,120 --> 01:24:40,440
+Predictive Value أو إذا فيه إشي 98%فالفكرة هنا لو
+
+927
+01:24:40,440 --> 01:24:43,560
+أنا استخدمته في الـ population اللي كويسة المجموع
+
+928
+01:24:43,560 --> 01:24:46,940
+اللي كويسة أروح أعمل هذا الفحص كـ Diagnostic Test
+
+929
+01:24:46,940 --> 01:24:53,920
+راح يكون أنا بصير والله يعجبني أكثر الموضوع إذا
+
+930
+01:24:53,920 --> 01:24:57,310
+طلع Negativeإذا طلع Negative وعندي أنا هذا
+
+931
+01:24:57,310 --> 01:25:01,530
+Positive predictive value 98 وكذا ففاقت الـ Test
+
+932
+01:25:01,530 --> 01:25:05,250
+إني أنا لما أشوفه Negative أروح أقول هاي مش
+
+933
+01:25:05,250 --> 01:25:09,170
+Dementia خليني أروح أدور على سبب ثاني غير الحالة،
+
+934
+01:25:09,170 --> 01:25:18,590
+هذه بالطريقة هذه فالأمور هذه يعني الـ Test ممكن
+
+935
+01:25:18,590 --> 01:25:21,410
+كمان يكون الـ heterozygous أظن أن هذا الـ slide
+
+936
+01:25:21,410 --> 01:25:25,640
+الأخيروبكون إنه للـ Cystic Fibrosis مثلًا بيهمني
+
+937
+01:25:25,640 --> 01:25:28,720
+أني أدرس الموضوع لأن فيه في الـ population
+
+938
+01:25:28,720 --> 01:25:34,920
+اختلافات فالـ Career Testing الأصل مثلًا في الـ
+
+939
+01:25:34,920 --> 01:25:43,520
+Whites للجين 1 في 25 فلما يكون 1 في 25 بضربوا بعض
+
+940
+01:25:43,520 --> 01:25:49,760
+25 في 25 بطلع 3200 تقريبًا يعني، هيك يعني اللي هي
+
+941
+01:25:49,760 --> 01:26:00,900
+الـ Incidence of Cystic Fibrosisالـ Career Status
+
+942
+01:26:00,900 --> 01:26:05,880
+بتكون يعني شوفوا الأرقام، اتطلع عليها ممكن نكمل
+
+943
+01:26:05,880 --> 01:26:09,880
+المحاضرة الجاية بهذا الجزء قبل ما ندخل على الـ
+
+944
+01:26:09,880 --> 01:26:13,480
+Genetics أنا لازم أطلع عندي هسه شغل ثاني فالله
+
+945
+01:26:13,480 --> 01:26:17,300
+يوفقكم وإذا حد عنده أسئلة يحط على الـ Group أو
+
+946
+01:26:17,300 --> 01:26:23,340
+يذكرنا فيها بداة المحاضرة القادمةماشي الحاجة الله
+
+947
+01:26:23,340 --> 01:26:26,020
+يرضى عليكم نشوفكم بخير ان شاء الله
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/mDsVoXEA6Pk_raw.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/mDsVoXEA6Pk_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..9a446e4c02db92f2ed667972d58ae1b67cbeaa52
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/mDsVoXEA6Pk_raw.srt
@@ -0,0 +1,3881 @@
+1
+00:00:00,000 --> 00:00:05,140
+أو في خلايا الإنسان واللي بتحكم في الوراثة من خلال
+
+2
+00:00:05,140 --> 00:00:11,920
+تحكمه في تكوين البروتين وشرحنا الأسس اللي عليها
+
+3
+00:00:11,920 --> 00:00:16,920
+تغييرات الـ DNA والجينات بتأدي لتغير الصفات
+
+4
+00:00:16,920 --> 00:00:23,980
+الوراثية بس كمان يعني اللي هو بدأنا نظهره أو بدأنا
+
+5
+00:00:23,980 --> 00:00:32,160
+نتكلم عنهاللي هو إنه هناك آليات للتحكم في ماذا يتم
+
+6
+00:00:32,160 --> 00:00:37,780
+نسخه أو كمية نسخه أو من أي مكان، كيفية نسخه من الـ
+
+7
+00:00:37,780 --> 00:00:43,360
+DNA، Transcription للـ RNA، فيه هناك آليات كمان
+
+8
+00:00:43,360 --> 00:00:54,340
+يتم يعني تفعيلها بحيث إنها تتم وتكون تؤثر أيضًا
+
+9
+00:00:55,490 --> 00:00:59,570
+فالمحصلة النهائية المظهرية عند أي إنسان هي ما
+
+10
+00:00:59,570 --> 00:01:04,030
+نسميه الـ Phenotype اللي هي المظهر كيف راح يكون
+
+11
+00:01:04,030 --> 00:01:11,110
+وهو المسئول عنه أولاً الـ Genotype اللي هو ما هي
+
+12
+00:01:11,110 --> 00:01:19,130
+الجينات المحددة اللي تمتلكها الخلايا ولكن أيضاً
+
+13
+00:01:19,130 --> 00:01:21,990
+كيف بتتم التحكم
+
+14
+00:01:23,060 --> 00:01:26,800
+أحيانًا تنشيط أو أحيانًا تثبيت هذه الجينات فهذا
+
+15
+00:01:26,800 --> 00:01:33,940
+كان ملخص المحاضرات السابقة اليوم بدنا نتكلم عن
+
+16
+00:01:33,940 --> 00:01:42,220
+درجة تعقيد الجينات اللي موجودة عند البني أدمين
+
+17
+00:01:42,220 --> 00:01:50,200
+وهنا احنا بدنا نرجع لدرجة الاختلاف بين البشر
+
+18
+00:01:50,200 --> 00:01:56,770
+عموماً يعنيما نتكلم على شخص واحد أحنا بنتكلم على
+
+19
+00:01:56,770 --> 00:02:03,010
+ظواهر يعني حتى يتم الواحد تقييمها أو حتى يعرفها
+
+20
+00:02:03,010 --> 00:02:10,390
+الواحد بده هيك يدرس كيف عموم الناس فالـChapter 4
+
+21
+00:02:10,390 --> 00:02:15,810
+is about human genetic diversities mutations and
+
+22
+00:02:15,810 --> 00:02:22,580
+polymorphismsالتغيير الظواهر أو التغيير الأشكال
+
+23
+00:02:22,580 --> 00:02:31,740
+النقطة الأولى يعني بالنسبة لموضوع زي هذا بده
+
+24
+00:02:31,740 --> 00:02:41,360
+الواحد أولاً يعني يكون على قدرة على إنهيصل إلى، زي
+
+25
+00:02:41,360 --> 00:02:47,300
+ما بيقولوا، المصدر، يصل إلى الأساس، من وين، شوه
+
+26
+00:02:47,300 --> 00:02:50,720
+الأساس اللي بتعتمد عليه، حتى تفهم أي شيء مرات
+
+27
+00:02:50,720 --> 00:02:53,460
+كثيرة، بدك تكون فاهمان من وين الأساس أجا.
+
+28
+00:02:56,500 --> 00:03:04,560
+فبصراحة، كطب سريري، بالذات إذا الواحد، وجزء كبير،
+
+29
+00:03:04,560 --> 00:03:11,580
+يعني عدد كبير من الحالات،بتكون بنسميها وراثة
+
+30
+00:03:11,580 --> 00:03:17,360
+منديلية أو وراثة بتعتمد على اختلاق الـ Gene واحد
+
+31
+00:03:17,360 --> 00:03:23,100
+اللي هي الـ ففيه عندنا إذا الواحد بروح الـ PubMed
+
+32
+00:03:23,870 --> 00:03:30,050
+وهي بوقع مشهور وكبير ومجاني
+
+33
+00:03:30,050 --> 00:03:37,070
+الـ PubMed بتلاقي فيه أولاً الـ Online Mendelian
+
+34
+00:03:37,070 --> 00:03:41,430
+Inheritance يعني
+
+35
+00:03:41,430 --> 00:03:50,710
+الـ Depository أو اللي هو المرجعالـ PubMed اللي هو
+
+36
+00:03:50,710 --> 00:03:58,090
+بيشرحلك إذا شكيت فيه إنه مرض مانديلي وعندك يعني
+
+37
+00:03:58,090 --> 00:04:02,070
+رغبة إنك تفهم عنه أكثر وإين بالضبط المشكلة أنه
+
+38
+00:04:02,070 --> 00:04:07,410
+جين، شو صار، كيف أنواعه، كيف كده فالـ PubMed هو
+
+39
+00:04:07,410 --> 00:04:18,540
+المرجع المناسب الآنأفرض أنا عندي عائلة أو شخص عنده
+
+40
+00:04:18,540 --> 00:04:24,960
+طفرة أو عنده حالة أو مرض وشكيت إنه ورافي من
+
+41
+00:04:24,960 --> 00:04:30,820
+الأشياء المطلوبة إن أنا أخد الـDNA تبعهوإذا كنت
+
+42
+00:04:30,820 --> 00:04:35,180
+بعرف، راح نحكي عنها بتفاصيل أكتر بعدين إذا كنت
+
+43
+00:04:35,180 --> 00:04:41,320
+بعرف وين الخلل في أي جين ممكن أروح أدرس نفس الجين،
+
+44
+00:04:41,320 --> 00:04:47,080
+هو أنا بسهل عليا كثير بدل ما أدرس الـ 25 ألف جين
+
+45
+00:04:47,080 --> 00:04:53,340
+صعب وطويل كثير، والآن صحيح صارت أسهل القضية اللي
+
+46
+00:04:53,340 --> 00:04:59,230
+هو نفس مبدأ الـ Human Genome Projectفأنا إذا بقدر
+
+47
+00:04:59,230 --> 00:05:07,690
+بروح بشوف قطعة مثلًا معينة وبدرسها وراح ناخد أمثلة
+
+48
+00:05:07,690 --> 00:05:13,550
+على ذلك إنه أحيانًا أنا بستطيع أركز وين الخلل
+
+49
+00:05:13,550 --> 00:05:21,110
+المحتمل يكون إذا عندي مثلًا عائلة فيها الأب والأب
+
+50
+00:05:21,110 --> 00:05:25,290
+والأم وشوية أخوة بعضهم مصابين بعضهم غير مصابين
+
+51
+00:05:25,970 --> 00:05:32,650
+فبعدين بدرس بشكل أوسع شوية يعني ما بعمل PCR لـ
+
+52
+00:05:32,650 --> 00:05:37,610
+Individual أو لكل الـ Sequencing لكل الأشياء بعمل
+
+53
+00:05:37,610 --> 00:05:42,590
+لقطعة اللي بظن فيها مشكلة وهي بتكون إنه أنا إذا
+
+54
+00:05:42,590 --> 00:05:48,050
+عندي أكثر من شخص بعضهم مصابين بعضهم غير مصابين
+
+55
+00:05:48,050 --> 00:05:52,810
+فلما أنا أقارن بين المجموعتين ممكن أحدد إنه نتيجة
+
+56
+00:05:52,810 --> 00:05:56,730
+ذلك إنه في جيل معين هو اللي فيه مشكلةفأفرض أنا
+
+57
+00:05:56,730 --> 00:06:03,170
+حصلت على هذا الـGene ناشي، وأنا بقدر يمكن هذا غير
+
+58
+00:06:03,170 --> 00:06:07,010
+معروف عند أي حد في العالم وأنا بكون بقارن بين اللي
+
+59
+00:06:07,010 --> 00:06:12,370
+مصابين وغير مصابين في المجموعة التبعتي بس نفترض إن
+
+60
+00:06:12,370 --> 00:06:22,120
+أنا بحاجة أو بدي أو أرغب إنيأعمل مقارنة لما أعتبره
+
+61
+00:06:22,120 --> 00:06:25,700
+هو الإنسان السليم أو الإنسان المرجعي أو الإنسان
+
+62
+00:06:25,700 --> 00:06:33,720
+الأساسي فهناك عدة يعني مراجع مفيدة ومهمة وكثير
+
+63
+00:06:33,720 --> 00:06:37,860
+منها مجاني يعني إذا أحتاج الواحد يشتغل هذا الشغل
+
+64
+00:06:37,860 --> 00:06:44,720
+وبحاجة إلى إنه يقارن بشيء مختلف ففي هذه مجموعة
+
+65
+00:06:44,720 --> 00:06:49,520
+مراجعالـ Human Genome Project اللي هو أوسع واحد
+
+66
+00:06:49,520 --> 00:06:58,060
+وأول واحد من 2003 بدأ يكون موجود وتقريبًا كامل لكل
+
+67
+00:06:58,060 --> 00:07:05,920
+المادة الوراثية تبع بني آدم يعتبر أنه سليم فاحنا
+
+68
+00:07:05,920 --> 00:07:10,560
+ناخد كيف أن هذا الكلام يعني مش مية بالمية دقيق
+
+69
+00:07:10,560 --> 00:07:16,250
+بقدر ما أنه متاحوممكن لما أنا ألاقي قطعة معينة
+
+70
+00:07:16,250 --> 00:07:20,990
+فيها خلل أو فيها تغير بطريقة معينة أسير أدور إنه
+
+71
+00:07:20,990 --> 00:07:26,910
+ممكن هذا اللي يكون الـ… الـ… الأقل ويكون مفيد يعني
+
+72
+00:07:26,910 --> 00:07:32,680
+اللي هقارن فيهفالـ «Human Genome Project» ممكن من
+
+73
+00:07:32,680 --> 00:07:40,900
+أول المشاريع بس فيه كمان ناس بيحاولوا يجمعوا كمان
+
+74
+00:07:40,900 --> 00:07:47,020
+قواعد بيانات عن الإختلالات الموجودة أو الطفرات
+
+75
+00:07:47,020 --> 00:07:51,890
+الموجودة أو الـPolymorphism الموجودةفهي أنه تستطيع
+
+76
+00:07:51,890 --> 00:07:56,970
+الواحد استفيد منها في قضية تقييم إذا كان هناك طفرة
+
+77
+00:07:56,970 --> 00:08:02,150
+معينة رأيناها إنها غير معلومة أو معلومة من قبل، أو
+
+78
+00:08:02,150 --> 00:08:07,150
+ما هو معروف عنها أو ما هو مش معروف عنهافهذه يعني
+
+79
+00:08:07,150 --> 00:08:14,510
+مراجع لعامة الناس لا تفيد يعني إنما إذا واحد منكم
+
+80
+00:08:14,510 --> 00:08:18,970
+إن شاء الله في المستقبل كان يكون عنده مختبر وعنده
+
+81
+00:08:18,970 --> 00:08:22,630
+إمكانية أو عنده عائلة عندها مشكلة وبيحب يدرسها
+
+82
+00:08:22,630 --> 00:08:27,850
+بشكل أدق حتى يصف كيف نوعية أنماط الإختلالات
+
+83
+00:08:27,850 --> 00:08:33,810
+الموجودة عندنا فهذه المراجع هذه مهمة وبذكركم كمان
+
+84
+00:08:33,810 --> 00:08:38,950
+إن الـ PubMedهذا إذا الواحد دخل فيه تحت غير الـ
+
+85
+00:08:38,950 --> 00:08:44,470
+Online Mendelian Database اللي حكينا عنها بتقدر
+
+86
+00:08:44,470 --> 00:08:49,650
+بيحطلك الـ DNA Sequence الـ RNA Sequence الـ
+
+87
+00:08:49,650 --> 00:08:56,430
+Protein Sequence وبحط المراجع هناك لكل الكائنات
+
+88
+00:08:56,430 --> 00:09:03,470
+الحية يعني مش بس الإنسانيعني إذا في المناعة لأنني
+
+89
+00:09:03,470 --> 00:09:07,850
+متخصص فيها اللي بتسمعه بالـ Toll-like receptors
+
+90
+00:09:07,850 --> 00:09:13,470
+اللي هي تستخدم في المناعة لـ مثلا التعرف على
+
+91
+00:09:13,470 --> 00:09:19,180
+الجراثيم هي حقيقة موجودة بالذبابةولأ، لما لاحظوا
+
+92
+00:09:19,180 --> 00:09:22,280
+أن الـ Sequence اللي في الإنسان في هذا المكان
+
+93
+00:09:22,280 --> 00:09:27,160
+مشابه لشيء معين موجود في الذبابة، في الـ DNA والـ
+
+94
+00:09:27,160 --> 00:09:33,220
+Sequence تبع الـ DNA وكذا، إيش اسمه؟ كانت القضية
+
+95
+00:09:33,220 --> 00:09:42,850
+مفيدة ومنبهة لإحتمالية وجود آليات معينةالنقطة
+
+96
+00:09:42,850 --> 00:09:47,130
+الأخيرة لما نقول إنه في الـ databases فيه أشياء
+
+97
+00:09:47,130 --> 00:09:51,610
+على مستوى الـ DNA على مستوى الـ RNA وعلى مستوى
+
+98
+00:09:51,610 --> 00:09:55,390
+البروتين على الثلاث مستويات هذه، بدل واحد يتذكر
+
+99
+00:09:55,390 --> 00:09:59,470
+إنه، راح نحكي بعد شوية على الـ SNP اللي هو Single
+
+100
+00:09:59,470 --> 00:10:04,790
+Nucleotide Polymorphism تغير في قاعدة نيتروجينية
+
+101
+00:10:04,790 --> 00:10:09,830
+واحدة، قدفي كثير من الأحيان أو في الغالبية قد لا
+
+102
+00:10:09,830 --> 00:10:14,250
+يكون هناك تغيير في البروتين الناتج فإنتهاء شغل
+
+103
+00:10:14,250 --> 00:10:22,430
+ممكن بالأخير تكون وظيفيا غير مؤثرة مع إنها يمكن
+
+104
+00:10:22,870 --> 00:10:28,090
+كاختلاف على مستوى الـ «DNA» موجود بس من ناحية
+
+105
+00:10:28,090 --> 00:10:34,310
+البروتين نفسه قد لا يكون هناك نتيجة في أسئلة فهذا
+
+106
+00:10:34,310 --> 00:10:43,090
+بدينكم في وصف درجة التعقيد ودرجة الاختلاف بين
+
+107
+00:10:43,090 --> 00:10:51,000
+البشر وليس في شخص واحدماشي، هناك مراجع متعددة ممكن
+
+108
+00:10:51,000 --> 00:10:57,500
+الاستفادة منها في أنه نفهم التعقيد
+
+109
+00:10:57,500 --> 00:11:03,660
+للجينات والمادة الوراثية في الإنسان عموماً، ماشي؟
+
+110
+00:11:03,660 --> 00:11:15,680
+في أسئلة؟ إذا حد عنده سؤال، يسأله الـ
+
+111
+00:11:19,390 --> 00:11:27,430
+هناك أنواع متعددة من التفرات أو التغيرات أو
+
+112
+00:11:27,430 --> 00:11:31,290
+الأشكال
+
+113
+00:11:31,290 --> 00:11:36,870
+والأنماط من التغيرات في الـDNA برجع بذكر مرة ثانية
+
+114
+00:11:36,870 --> 00:11:40,070
+على اعتبار أنه نعتبرنا اللي بدأنا فيه دراسة
+
+115
+00:11:40,070 --> 00:11:45,610
+الـHuman Genome إنه اللي افترض أنه إنسان المرجع
+
+116
+00:11:46,370 --> 00:11:52,670
+وهذه بس نقطة حتى نبدأ نعرف كيف نقيم فهناك أنواع
+
+117
+00:11:52,670 --> 00:11:58,010
+مختلفة من قضايا الاختلالات
+
+118
+00:11:58,010 --> 00:12:05,290
+أو التغيرات والأشياء الرئيسية منها نضعها مثلاً في
+
+119
+00:12:05,290 --> 00:12:12,710
+أربع أشكال وأنماط فهناك Single Nucleotide
+
+120
+00:12:12,710 --> 00:12:18,760
+Polymorphismوهذه على One Base Pair يعني قاعدة
+
+121
+00:12:18,760 --> 00:12:25,660
+نيتروجينية زوج واحد فقط منها في محل واحد بيكون في
+
+122
+00:12:25,660 --> 00:12:35,560
+اختلال إنه راح يكون بدل حرف معين بيصير حرف ثاني
+
+123
+00:12:35,560 --> 00:12:44,400
+النوع الثاني هي قضية يا إما خلل فييعني عملية
+
+124
+00:12:44,400 --> 00:12:51,940
+الانقسام وبناء الـDNA بحيث أنه يتم يا إما حفظ أو
+
+125
+00:12:51,940 --> 00:13:00,280
+إضافة أحيانًا من يعني قاعدة نيتروجينية واحدة إلى
+
+126
+00:13:00,280 --> 00:13:07,220
+حوالي مائة فهدولة يعني يا إما insertion عملية
+
+127
+00:13:07,220 --> 00:13:14,120
+إدخال أو deletion عملية حذففيطلق عليها كلمة Endels
+
+128
+00:13:14,120 --> 00:13:21,000
+يعني Insertions أو Deletions وبتكون ممكن تكون ما
+
+129
+00:13:21,000 --> 00:13:25,660
+بين قاعدة واحدة يعني Single nucleotide
+
+130
+00:13:25,660 --> 00:13:28,300
+polymorphism في الغالب اللي راح نحكي يمكن ما تأثرش
+
+131
+00:13:28,300 --> 00:13:33,440
+بس الـInsertion والـDeletion لأ لها تأثير قوي عادة
+
+132
+00:13:33,440 --> 00:13:38,780
+وأحياناً قد تصل إلى 100 يعني سلسلة من 100 قاعدة
+
+133
+00:13:38,780 --> 00:13:47,910
+نيتروجينيةفكان بتكون على شكل بسيط ماشي أو إنه
+
+134
+00:13:47,910 --> 00:13:52,610
+بتكون على طريقة تكون معقدة بتكون تسموها Micro
+
+135
+00:13:52,610 --> 00:13:58,530
+-satellite يعني نبارة عن قطعة أكبر من القواعد
+
+136
+00:13:58,530 --> 00:14:05,790
+النيتروجينية التي يمكن أن تضاق أو أن تحدثماشي، ف…
+
+137
+00:14:05,790 --> 00:14:11,010
+دكتور، في سؤال من كريم بخصوص الـ… الـ… يعني آخر
+
+138
+00:14:11,010 --> 00:14:14,090
+عمود في الجدول اللي هو الـNumbers أو الـNumber of
+
+139
+00:14:14,090 --> 00:14:17,830
+Elites، أيش اللي بيقصد فيه هنا يعني؟ لما يجي تتكلم
+
+140
+00:14:17,830 --> 00:14:24,050
+عن سؤال، فضل. الآن، يعني هذه ظاهرة دمّا تحدث،
+
+141
+00:14:24,050 --> 00:14:29,250
+ماشي، في Single Nucleotide Polymorphism، راح نحكي
+
+142
+00:14:29,250 --> 00:14:34,790
+حوالي عددها كبير، عادة عندنا الأصليفهذا one أليل
+
+143
+00:14:34,790 --> 00:14:38,170
+بيكون بشكل معين واللي فيه الـ Substitution راح
+
+144
+00:14:38,170 --> 00:14:42,320
+يكون الأليل الثانيفعادةً إحنا بنتكلم على إنه أنا
+
+145
+00:14:42,320 --> 00:14:47,140
+Two عندي Two Alleles Alleles اللي هو النسخ
+
+146
+00:14:47,140 --> 00:14:51,620
+الموجودة من الجين في هذا الموقع كام شكل هي موجودة
+
+147
+00:14:51,620 --> 00:14:56,460
+فيه يعني بنقول الـ ABO System إنه ثلاثي Alleles يا
+
+148
+00:14:56,460 --> 00:15:01,500
+إما A يا إما B يا إما O على مستوى الجين على مستوى
+
+149
+00:15:01,500 --> 00:15:06,220
+الـDNA، ماشي؟ فلما نكون عنده Single Nucleotide
+
+150
+00:15:06,220 --> 00:15:10,190
+Polymorphismبقول إنه عادة في عندى Two Alleles
+
+151
+00:15:10,190 --> 00:15:16,070
+ماشي، الآن راح نيجي ناخد يعني الأشياء، الأليل هو
+
+152
+00:15:16,070 --> 00:15:21,790
+شكل الـGene اللي ممكن يحل في هذا المحل، ماشي، في
+
+153
+00:15:21,790 --> 00:15:28,940
+هذا المكان من الـDNA، لما نكونالاختلالات يعني
+
+154
+00:15:28,940 --> 00:15:32,300
+عادةً إحنا ليش عرفنا إنه صار «deletion» أو صار
+
+155
+00:15:32,300 --> 00:15:36,260
+«insertion» لأنه قررنا بإيش مرجعي فبيّن معانا إن
+
+156
+00:15:36,260 --> 00:15:41,600
+هنا صار في مثلا حذف أو إضافة فلما يكون عندي حذف أو
+
+157
+00:15:41,600 --> 00:15:48,180
+إضافة بيكون عندي شو اسمه نسخ تاني إذا كانت simple
+
+158
+00:15:48,180 --> 00:15:56,200
+فظاهرة إنه على شكل مجموعة وممكن كذا مرة تتكرر فأن
+
+159
+00:15:56,200 --> 00:16:02,600
+أنماط الإختلالات أو الأليل الموجودة كلمة أليل لازم
+
+160
+00:16:02,600 --> 00:16:07,240
+تكونوا عارفينها يعني فاهمينها إنه في نفس الموقع
+
+161
+00:16:07,240 --> 00:16:11,940
+إذا البروتين أو الـ الـ الـ الـ الـ الجين إله أكثر
+
+162
+00:16:11,940 --> 00:16:17,100
+من شكل وكلهم بحلوا في نفس المحل فبتسموه أليل يعني
+
+163
+00:16:17,100 --> 00:16:23,440
+مثلا نحكي مثلا على الـ HLA System اللي هو تبع
+
+164
+00:16:23,440 --> 00:16:32,550
+المناعةالـ HLA-A اللي هو فيه HLA-A وB وC هدولة فيه
+
+165
+00:16:32,550 --> 00:16:38,590
+خمسمائة قليل، ستمائة قليل يعني في عموم البشر،
+
+166
+00:16:38,590 --> 00:16:44,190
+ماشي، فيه خمسمائة نوع، شكل بس في أي إنسان بتلاقي
+
+167
+00:16:44,190 --> 00:16:48,610
+منه ثنتين لأنه عندي أنا two copies ويله مكان واحد
+
+168
+00:16:49,020 --> 00:16:54,000
+لما نقول قليل يعني اللي هو البديل البدلاء اللي
+
+169
+00:16:54,000 --> 00:16:57,160
+ممكن يحلوا في هذا المكان على أكثر، على كام شكل
+
+170
+00:16:57,160 --> 00:17:03,920
+فالـ الـ الـ لما تكون الـ insertion و الـ deletion
+
+171
+00:17:03,920 --> 00:17:12,160
+إذا simple يعني عبارة عن قطعة صغيرة تم حذفها فلأ،
+
+172
+00:17:12,160 --> 00:17:18,940
+بتكون عبارة عن نسختين، يعني ممكناتماشي لما تكون
+
+173
+00:17:18,940 --> 00:17:26,060
+أكثر من إمكانية تكرار بالذات الإضافة ممكن مثلا
+
+174
+00:17:26,060 --> 00:17:31,860
+قطعة من خمس nucleotides تم إضافتهم بس في نسخة
+
+175
+00:17:31,860 --> 00:17:38,910
+معينة بتلاقي هذا التكرار مرتين وفيبنسخة ثانية في
+
+176
+00:17:38,910 --> 00:17:46,770
+القليل الثاني مثلًا أربع نسخة تم إضافتهم
+
+177
+00:17:46,770 --> 00:17:51,550
+كلمة قليل ما تعني في نفس الشخص تعني في ال
+
+178
+00:17:51,550 --> 00:17:56,290
+population تعني في البشر كلهم شوهو البدائل
+
+179
+00:17:56,290 --> 00:18:01,570
+الموجودة لهذا المكان في هناك أيضًا الـ Copy Number
+
+180
+00:18:01,570 --> 00:18:09,250
+Variants اللي هوبتلاقي إنه قطعة كبيرة وفيها جينات
+
+181
+00:18:09,250 --> 00:18:14,150
+كثيرة وبتلاقي إنها بتتم تكرارها أكتر من مرة يعني
+
+182
+00:18:14,150 --> 00:18:20,190
+بدرب مرة ثالثة لما نتكلم عن الـ Hemoglobin genes
+
+183
+00:18:20,190 --> 00:18:24,890
+الـ Beta-Globulin، الـ Beta-Chain، إلها نسخة واحدة
+
+184
+00:18:24,890 --> 00:18:32,730
+ففي عندي Two copies يعني بكون عندي محل واحدوهك
+
+185
+00:18:32,730 --> 00:18:37,710
+موجود، بس الـ «الفا تشين» فيه two copies منها
+
+186
+00:18:37,710 --> 00:18:42,670
+exactly the same ففيه مرات variation إنه بالـ
+
+187
+00:18:42,670 --> 00:18:48,310
+number of the copies of the variants هو بتلاقي
+
+188
+00:18:48,310 --> 00:18:53,110
+اثنين أو مرات أكتر، وفيه ال inversion راح نشوف
+
+189
+00:18:53,110 --> 00:18:57,690
+أمثلة عنها، وبرضه باعتبروا هنا إنه بكون عندى ال
+
+190
+00:18:57,690 --> 00:19:05,590
+possibility بهذا الشكل two allelesماشي، الآن هاي
+
+191
+00:19:05,590 --> 00:19:10,710
+مرة ثالثة نرجع نجي لمثال عرضناه من قبل قبل
+
+192
+00:19:10,710 --> 00:19:14,970
+المحاضرة الثانية أنه أنا بكون عندي reference range
+
+193
+00:19:14,970 --> 00:19:24,040
+طبعا حتى أصل هذه المرحلةبكون أنا بعمل أول شيء يعني
+
+194
+00:19:24,040 --> 00:19:28,780
+إن أنا بطريقة ما من خلال دراسة العائل المصاب وغير
+
+195
+00:19:28,780 --> 00:19:32,940
+المصاب قدرت أحدد قطعة معينة فيها مشكلة يعني بروتين
+
+196
+00:19:32,940 --> 00:19:37,000
+معين، جين معين هو اللي عنده مشكلة فباجي وقتها
+
+197
+00:19:37,000 --> 00:19:42,440
+بواسطة الـPCR تقنية معينة بروح بسوء Sequencing
+
+198
+00:19:42,440 --> 00:19:46,520
+يعني بروح بقرا شو الـNucleotides الموجودة في هذه
+
+199
+00:19:46,520 --> 00:19:52,580
+القطعةفإذا أنا عندي Reference معين اللي هو موجود
+
+200
+00:19:52,580 --> 00:19:56,900
+لهاي القطعة عند الـ Human Genome Project أو من
+
+201
+00:19:56,900 --> 00:20:04,660
+المحل المعين وبعدي بدرس الشخص الأول نفترض أو الفرد
+
+202
+00:20:04,660 --> 00:20:11,460
+الأول لما ألاقي إنه القراءة عنده بهذا الشكل فهو
+
+203
+00:20:11,460 --> 00:20:15,880
+عنده Two Allelesالأليل الأول طبعًا من الخمس إلى
+
+204
+00:20:15,880 --> 00:20:18,800
+الثلاث هو اللي بنقراها هو اللي بنعتمدها هو اللي
+
+205
+00:20:18,800 --> 00:20:25,140
+بنعتمد عليها التاني complementary مكافئة لها ولقيت
+
+206
+00:20:25,140 --> 00:20:30,720
+إشي مشابه تمامًا للـReference Sequence فهذه كانت
+
+207
+00:20:30,720 --> 00:20:36,700
+جزء ما في مشكلة لما جيت أقرأ الأليل الثانياللي
+
+208
+00:20:36,700 --> 00:20:40,420
+رأيته كانت تالي، اللي هو بهذا الشكل ما الذي حصل
+
+209
+00:20:40,420 --> 00:20:44,060
+هنا؟ اللي حصل هنا أن هذا الـ Position اللي هو
+
+210
+00:20:44,060 --> 00:20:50,620
+تقريبا رقم 8 ماشي، Position 8 في هذا الـ Sequence
+
+211
+00:20:50,620 --> 00:20:53,920
+وفي هذه القطعة، في هذا الـ Intro أو الـ X Zone أو
+
+212
+00:20:53,920 --> 00:21:00,130
+كده بدل ما هي T صارت Cفبمثل هذا الشكل يعني الواحد
+
+213
+00:21:00,130 --> 00:21:05,350
+بيلاحظ إنه اللي قبل واللي بعد كله تماما زي
+
+214
+00:21:05,350 --> 00:21:10,330
+الـReference Sequence ماصاش أي اختلاف فهذا نسميه
+
+215
+00:21:10,330 --> 00:21:14,810
+SNP Single Nucleotide Polymorphism فبنيجي نقراها
+
+216
+00:21:14,810 --> 00:21:18,650
+ثلاثات ثلاثات ثلاثات ثلاثاتالاحتمال أن هذا
+
+217
+00:21:18,650 --> 00:21:22,770
+الاختلاف قد يكون وارد أنه ليس له قيمة لأن هؤلاء
+
+218
+00:21:22,770 --> 00:21:27,130
+الثلاثيات الذينتين هؤلاء بيعطي نفس البروتين
+
+219
+00:21:27,130 --> 00:21:31,250
+أحيانًا قد يكون بهذا الشكل وأحيانًا لأ بتكون تخلف
+
+220
+00:21:31,250 --> 00:21:34,570
+الـ Amino Acid وبالتالي بتخلف البروتين وبتخلف
+
+221
+00:21:34,570 --> 00:21:42,310
+الوظيفة لو جيت على إنسان آخر ولقيت كالتالي النسخة
+
+222
+00:21:42,310 --> 00:21:48,460
+الأولى تمامًا زي اللي فوق النسخة الثانيةقريبة منها
+
+223
+00:21:48,460 --> 00:21:56,820
+بس اللي تم هو إضافة الـ «نيكليوتاد» الزيادة عشان
+
+224
+00:21:56,820 --> 00:22:01,720
+هيك شايفين هذا الطرف فوق طالق لفوق، يعني الزيادة،
+
+225
+00:22:01,720 --> 00:22:07,100
+ماشي، فطبعاً هذا ع كروموزوم و هذا ع كروموزوم، مش
+
+226
+00:22:07,100 --> 00:22:12,320
+اتنين يعني نحكي عن مسكتين الـDNA اللي قُبقى البعض،
+
+227
+00:22:12,320 --> 00:22:19,250
+أدوله ما لهم دخل البعض، يعني مش، شو اسمه؟يعني ما
+
+228
+00:22:19,250 --> 00:22:26,390
+بيكونوا قبال بعض يعني هيك فهنا هذا الجزء راح يمشي
+
+229
+00:22:26,390 --> 00:22:30,910
+كويس بس لما انتظر بهذه الطريقة Single nucleotide
+
+230
+00:22:30,910 --> 00:22:35,730
+insertion وعلى الـ Position هذا هذه النقطة وما
+
+231
+00:22:35,730 --> 00:22:41,390
+بعدها كله راح يخرب كله راح يكون قراءته مش صحيحة
+
+232
+00:22:41,390 --> 00:22:45,630
+الثلاثيات راح تتغير كثير فهذا تأثيره على هذا
+
+233
+00:22:45,630 --> 00:22:51,180
+البروتين أو على هذا الـGeneكارثي أو كبير جداً إذا
+
+234
+00:22:51,180 --> 00:22:57,680
+صار insertion لثلاثة nucleotides لأ والله ممكن أنه
+
+235
+00:22:57,680 --> 00:23:03,900
+تعد الأمور وتكون الأمور مقبولة يعني هنا تم إضافة
+
+236
+00:23:03,900 --> 00:23:09,260
+شو اسمه يعني الـ nucleotide أو nitrogenous base
+
+237
+00:23:09,260 --> 00:23:17,280
+زيادة هنا تم حذف نسختينفطبعًا مش راح يكون بهذا
+
+238
+00:23:17,280 --> 00:23:21,200
+الشكل اللي راح يكون الـC راح تيجي تحت الـT والـT
+
+239
+00:23:21,200 --> 00:23:26,920
+تحت الـT وكذا هتلاقي اللي تحتاني الأليل الثاني Two
+
+240
+00:23:26,920 --> 00:23:33,940
+nucleotides smaller فهي دواهر موجودة وهنا إحنا
+
+241
+00:23:33,940 --> 00:23:41,560
+بنحكي عن إنه أنا قمت بدراسة الـDNA على مستوى أحرف
+
+242
+00:23:41,560 --> 00:23:48,040
+الـNucleotides تبعاتهفي قطعة معينة وراح نحكي عنها
+
+243
+00:23:48,040 --> 00:23:54,680
+بعد شوية تفاصيل أكتر من ناحية أيش الـ الـ الـ يعني
+
+244
+00:23:54,680 --> 00:24:01,580
+الـ أيش التجارب أو أيش الأجهزة أو أيش الـ الاشي
+
+245
+00:24:01,580 --> 00:24:07,980
+اللي بيخليني أقدر أصل لهذه النقطة فيها أسئلة؟
+
+246
+00:24:07,980 --> 00:24:11,720
+فالأول
+
+247
+00:24:12,940 --> 00:24:16,260
+في الغالب يمكن ما يكونش له تأثير أو في احتمال قليل
+
+248
+00:24:16,260 --> 00:24:19,900
+إن يكون له تأثير الثاني والثالث اللي هم تهدرات
+
+249
+00:24:19,900 --> 00:24:23,640
+كبيرة جداً لو كانت الـInsertion أو الـDeletion
+
+250
+00:24:23,640 --> 00:24:32,980
+لثلاث نيكليوتايد كان لأ، راح يصير كله كويس حكينا،
+
+251
+00:24:32,980 --> 00:24:34,220
+فيها سؤالة
+
+252
+00:24:39,410 --> 00:24:43,850
+حكينا إنه ممكن أن يكون عندي Copy Number Variation
+
+253
+00:24:43,850 --> 00:24:49,650
+يعني هي إحنا هنا حسا طلعنا من الـ Single
+
+254
+00:24:49,650 --> 00:24:54,950
+Nucleotide Mutations يعني كل الأمثل اللي حكيناها
+
+255
+00:24:54,950 --> 00:25:03,170
+هي عبارة عن بتكون على مستوى الحرف الواحد ممكن تكون
+
+256
+00:25:03,170 --> 00:25:11,550
+عندي اختلالاتبرضه على مستوى إنه القطعة أكبر فهي
+
+257
+00:25:11,550 --> 00:25:15,070
+بيسموها Micro-satellite polymorphism يعني تكون
+
+258
+00:25:15,070 --> 00:25:19,090
+عندي قطعة أكبر ممكن توصل إنها تكون Gen أو كذا
+
+259
+00:25:19,090 --> 00:25:25,030
+أحيانًا يعني لو لاحظت أنا شغلي زي هيك مثلًا ناخد
+
+260
+00:25:25,030 --> 00:25:29,910
+هذا المثال بالأولإنه أنا قطعة بلاقي فيها إذا درست
+
+261
+00:25:29,910 --> 00:25:36,030
+ترتيبها في قطع تلاقيها A B C D E F G ماشي بالترتيب
+
+262
+00:25:36,030 --> 00:25:42,630
+A B وبعدين E D C ومن هنا F G H، شو اللي صار؟ إنه
+
+263
+00:25:42,630 --> 00:25:47,470
+هذه القطعة بالكامل جلبت طبعاً هذا على الأليل الأول
+
+264
+00:25:47,470 --> 00:25:51,780
+وهذا على الأليل الثانييعني شو هذا على كرموزوم و
+
+265
+00:25:51,780 --> 00:25:55,460
+هذا على كرموزوم مانا مدخل ببعض يعني مش احنا بنحكي
+
+266
+00:25:55,460 --> 00:26:00,240
+على نسختين اللي قبال بعض في مرات بيصير عندي copy
+
+267
+00:26:00,240 --> 00:26:05,700
+number variation A B C D E الـ F G بدل ما هي مرة
+
+268
+00:26:05,700 --> 00:26:13,280
+واحدة صارت F G F G F G H فصارت ثلاث مرات فهي بتكون
+
+269
+00:26:13,280 --> 00:26:17,160
+في اختلال معين«Mobile element insertion
+
+270
+00:26:17,160 --> 00:26:22,460
+polymorphism» يعني برضه قطعة إلى دخل بالتوجيه
+
+271
+00:26:22,460 --> 00:26:30,360
+بتلاقيها في اختلال بينها صارت أبعة وكانها متحركة،
+
+272
+00:26:30,360 --> 00:26:37,190
+فهذه يعني ظواهرعلى مستوى بنسميها Micro-satellite
+
+273
+00:26:37,190 --> 00:26:41,730
+يعني مش Single Nucleotide بدها طريقة دراسة أكبر
+
+274
+00:26:41,730 --> 00:26:48,210
+بدها يعني حتى نستطيع أنه نعرف أنه هاي على مستوى
+
+275
+00:26:48,210 --> 00:26:51,070
+Micro-satellite أنا مش داخل هنا على مستوى
+
+276
+00:26:51,070 --> 00:26:53,830
+الـNucleotides أنا ببدأ بالـNucleotides
+
+277
+00:26:53,830 --> 00:26:58,430
+والـSequencing وبعدين باخد قطعة بالكامل وبشوف شو
+
+278
+00:26:58,430 --> 00:27:01,250
+الاختلافات بينها ماشي؟
+
+279
+00:27:05,680 --> 00:27:13,860
+الآن يعني أنا بفضل إنه الواحد صحيح بالأخير
+
+280
+00:27:13,860 --> 00:27:17,720
+بيرسموله الرسم هذه وبيصيره
+
+281
+00:27:19,790 --> 00:27:28,070
+يعني يطلبوا منه يفهمها في دراسة أو كده وبتكون يعني
+
+282
+00:27:28,070 --> 00:27:32,510
+أحياناً بدك تكون اشتغلت في مختبر وشوفت كيف تنعمل
+
+283
+00:27:32,510 --> 00:27:39,790
+وبعدين عشان تفهم الكلام اللي تذكره هنا بحاول يعني
+
+284
+00:27:39,790 --> 00:27:48,750
+هي hypothetical يعني نظرية أنه أنا عنديالقطعة الـ
+
+285
+00:27:48,750 --> 00:27:52,910
+DNA بسوي
+
+286
+00:27:52,910 --> 00:27:59,050
+بيسموه Markers بيسميها مرات Markers عبارة عن يعني
+
+287
+00:27:59,050 --> 00:28:06,280
+قطعة شويه أكبر من الـ DNAوإن يكون الأحرف يعني
+
+288
+00:28:06,280 --> 00:28:13,580
+بترتيب معين يعني مثلا نفترض إذا استردنا يعني أنا
+
+289
+00:28:13,580 --> 00:28:18,020
+بقول دايماً الجينات تقريباً عشان تعطي بروتينات
+
+290
+00:28:18,020 --> 00:28:24,900
+نعتبرها زي قصيدة ماشي وبتلاقيك
+
+291
+00:28:24,900 --> 00:28:28,660
+لما بدك مثلا NASA، Google بدك تدور على إشي بتحط
+
+292
+00:28:28,660 --> 00:28:37,490
+كام من كلمة منبداية أو من البيت الشعر اللي بدك ياه
+
+293
+00:28:37,490 --> 00:28:43,990
+و بدك تعرفه و تستخدمها مثلًا يعني مثلًا باجي، أنا
+
+294
+00:28:43,990 --> 00:28:50,090
+بدي أدور على قصيدة «مروء القيس» المعلقة الأولى
+
+295
+00:28:50,090 --> 00:28:54,190
+يعني «قف أنا بكي من ذكرا، يا حبيبي» فبقول «قف أنا
+
+296
+00:28:54,190 --> 00:28:59,430
+بكي من ذكرا» لما أنا أحط قطعة أطول شوية، مش حرف
+
+297
+00:28:59,430 --> 00:29:04,870
+واحد أنا بحط، بحط مجموعةفكلمة «قفة نبكي» من ذكرة
+
+298
+00:29:04,870 --> 00:29:09,650
+مش راح تلاقيها في كثير من القصائد يعني هتكون شغل
+
+299
+00:29:09,650 --> 00:29:17,610
+نادرة فهي تقريبًا مميزة فقط لقصيدة «إمروه القيص»
+
+300
+00:29:17,610 --> 00:29:25,510
+فبالتالي أنا بستطيع أني أدرس وهنا بتكلم على مستوى
+
+301
+00:29:25,510 --> 00:29:32,860
+عائلي يعني أنا جبتالأب والأم والثلاث أطفال زي ما
+
+302
+00:29:32,860 --> 00:29:42,500
+هم حاطين هنا وعندهم هذه الشغل يعني دكتور، في سؤال
+
+303
+00:29:42,500 --> 00:29:48,020
+من دكتورة «كارميل» بخصوص اللي هو الـ «كوبي نمبر» و
+
+304
+00:29:48,020 --> 00:29:52,720
+«مايكروسوتالايت» وما هي الفرق بينهم؟ يعني الإتنين
+
+305
+00:29:52,720 --> 00:30:01,190
+في تقرار لـ «نيكوليوتس»؟ انتبع شغلياللي حكينا عنهم
+
+306
+00:30:01,190 --> 00:30:06,070
+بالنسبة
+
+307
+00:30:06,070 --> 00:30:10,630
+لما نتكلم على إنه بدي أستخدم الـMicrosatellite بدي
+
+308
+00:30:10,630 --> 00:30:16,350
+أستخدم يعني أنا بدي أشبهها الآن باللي بحكي عنه هما
+
+309
+00:30:16,350 --> 00:30:21,450
+شغلتين أشياء متقاربة اللي هي قضية إنه بطلنا نتكلم
+
+310
+00:30:21,450 --> 00:30:24,890
+على Single Nucleotide يعني هذه النقطة الأولى فاحنا
+
+311
+00:30:24,890 --> 00:30:29,510
+و أنا بنتكلم على قطعةماشي، فتعة قصيرة ممكن أطول
+
+312
+00:30:29,510 --> 00:30:36,170
+شويه لحد 100 نيوكلوتايد يعني اللي هين حاطينا هنا
+
+313
+00:30:36,170 --> 00:30:43,070
+ممكن يعني هاي اللي هي Micro-satellite لحد الـ 100
+
+314
+00:30:43,070 --> 00:30:48,290
+Base Pairs بينما الـ Copy Number Variance نحكي
+
+315
+00:30:48,290 --> 00:30:54,450
+ممكن من هنا من 10,000 لـ 1 مليون نيوكلوتايدالـ
+
+316
+00:30:54,450 --> 00:31:00,390
+Copy Number Variance برضه حاطينه على شكل شو اسمه؟
+
+317
+00:31:00,390 --> 00:31:06,270
+يعني على شكل قطعة أكبر من الـ DNA، ماشي؟ فأما
+
+318
+00:31:06,270 --> 00:31:13,350
+اثنينهم في قضية الممكن زيادة العدد يعني اللي هي
+
+319
+00:31:13,350 --> 00:31:18,110
+زيادة
+
+320
+00:31:18,110 --> 00:31:23,190
+عدد الـ Copies قصديفهنا هذه الأمثلة على الـ «Human
+
+321
+00:31:23,190 --> 00:31:26,830
+Genome Larger Than Snip» يعني خلاص، اتجاوزنا، أنا
+
+322
+00:31:26,830 --> 00:31:30,230
+بدأ أتكلم على هذه النقاط، بتكلم على إنه أنا بتعامل
+
+323
+00:31:30,230 --> 00:31:38,910
+مع يعني قطعة أكبر، سواء عدد قليل، «Nucleotides»
+
+324
+00:31:38,910 --> 00:31:43,570
+أربعة، خمس، عشرة، لحد مية أو حتى قطعة أكبر من
+
+325
+00:31:43,570 --> 00:31:55,520
+الـDNA، ماشي؟فاللي بدأ أحكيه هنا إنه المثال
+
+326
+00:31:55,520 --> 00:32:02,800
+هذا كاسمه «Microsatellite Marker Study» يعني عبارة
+
+327
+00:32:02,800 --> 00:32:09,700
+عن دراسة معينة هنا بنسميها فرضية أو تخيّلية أو
+
+328
+00:32:09,700 --> 00:32:16,080
+احتمالية تكون كذا اللي راح ألاقي كالتالي أناجبت
+
+329
+00:32:16,080 --> 00:32:22,460
+Marker اللي هي زي مجموعة كلمات مرتبة بطريقة معينة
+
+330
+00:32:22,460 --> 00:32:28,760
+زي «قفة نبكي من ذكرة» نستخدم هذه الكلمة فهذه
+
+331
+00:32:28,760 --> 00:32:32,340
+القطعة أنا باستفيد منها في قضية تدوير على هذا
+
+332
+00:32:32,340 --> 00:32:37,720
+الـGene اللي أنا قصدي أدور على جين معين في الحالة
+
+333
+00:32:37,720 --> 00:32:43,890
+هذه قصيدة «أبو العلاء المعرّف»بأجي أنا باستخدم هذا
+
+334
+00:32:43,890 --> 00:32:51,270
+الـ Marker وبدرس شو هو وضع العائل هذه بلاقي أن
+
+335
+00:32:51,270 --> 00:32:55,690
+مثلًا الأم طبعًا أحنا الآن الـ Marker لهذا الـ
+
+336
+00:32:55,690 --> 00:33:00,030
+Gene اللي هو للقطع هذه، هذا اللي أنا استخدمته
+
+337
+00:33:00,790 --> 00:33:07,150
+وبعدين بستخدم الـ Marker إن أنا أول شيء يعني زي ما
+
+338
+00:33:07,150 --> 00:33:11,910
+تقوله بكسر الـ DNA بشكل معين عساسي يكون قطعة أقل
+
+339
+00:33:11,910 --> 00:33:20,370
+وبعدين بعمل Electrophoresis يعني بخلي الـ DNA،
+
+340
+00:33:20,370 --> 00:33:26,030
+القطعة الـ DNA تمشي حسب الـ Electrical Charge تبعة
+
+341
+00:33:26,030 --> 00:33:32,200
+الـ Systemفإذا كان قطعة طبعاً بيحطوا مثلاً فوق
+
+342
+00:33:32,200 --> 00:33:39,080
+الـOrigin وبعدين بيخلوها تمشي فإذا كانت القطعة
+
+343
+00:33:39,080 --> 00:33:45,120
+كبيرة بتكون ثقيلة، بتتحركش إذا كانت القطعة صغيرة
+
+344
+00:33:45,120 --> 00:33:53,100
+فهي خفيفة فبتلاقيها تتحرك بشكل سريع فالفكرة
+
+345
+00:33:53,100 --> 00:33:58,940
+هنا في طريقة التناثرالـ الـ الـ الـ الـ الـ الـ
+
+346
+00:33:58,940 --> 00:33:58,940
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+347
+00:33:58,940 --> 00:33:58,940
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+348
+00:33:58,940 --> 00:33:59,140
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+349
+00:33:59,140 --> 00:33:59,960
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+350
+00:33:59,960 --> 00:34:00,000
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+351
+00:34:00,000 --> 00:34:10,460
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+352
+00:34:10,460 --> 00:34:10,760
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+353
+00:34:10,760 --> 00:34:13,880
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+354
+00:34:13,880 --> 00:34:19,300
+الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+355
+00:34:23,280 --> 00:34:28,200
+الطفل الثاني أخد من الأب هذه القطعة وأخد من الأم
+
+356
+00:34:28,200 --> 00:34:35,240
+القطعة الثانية وبالنسبة للشخص الثالث فهي يعني حسب
+
+357
+00:34:35,240 --> 00:34:44,480
+أنا إذا بقدر ألاقي كيف يعني مين المصاب ومين السليم
+
+358
+00:34:44,480 --> 00:34:48,700
+في العائلة وشو علاقة الأب بالأم وشو نوعيت متوقعة
+
+359
+00:34:48,700 --> 00:34:53,560
+تكون نوعيته الوراثةسائد، متنحي، وكذا، هذه طريقة
+
+360
+00:34:53,560 --> 00:35:00,240
+لدراسة الاختلافات الموجودة بينما لنفس هذا الموقع،
+
+361
+00:35:00,240 --> 00:35:06,180
+لنفس هذا الـGene، ماشي، لو جبت أشخاص آخرين من
+
+362
+00:35:06,180 --> 00:35:09,560
+الـPopulation، راح ألاقي لو كل واحد عنده Two
+
+363
+00:35:09,560 --> 00:35:15,100
+copies، في الغالب، بس بتكون أشكالهم مختلفة، فلما
+
+364
+00:35:15,100 --> 00:35:23,840
+نيجي نحكي هنا علىيعني كم قليل متوقع يكون موجود؟
+
+365
+00:35:23,840 --> 00:35:28,720
+يعني هذه العائلة فيها Two Alleles بس، ماشي؟ اللي
+
+366
+00:35:28,720 --> 00:35:34,660
+هم يعني أو هنا بدأ تكون Four Alleles، ماشي؟
+
+367
+00:35:34,660 --> 00:35:38,720
+أحيانًا إذا فيه Homozygous راح يطلع اثنين فوق بعض
+
+368
+00:35:38,720 --> 00:35:42,500
+يعني راح يبين في شخص عنده نسخة واحدة بس هنا Four
+
+369
+00:35:42,500 --> 00:35:47,060
+Alleles، بدنا نعتبر، ماشي؟ هنا الـAlleles أكثر حتى
+
+370
+00:35:47,660 --> 00:35:52,640
+في الـ Unrelated Individuals وهذه باستخدام تقنية
+
+371
+00:35:52,640 --> 00:36:00,220
+إنه أنا أدرس قطع الـ «جينوم» أو قطع الـ «DNA» بحيث
+
+372
+00:36:00,220 --> 00:36:05,820
+أنه أدرسها على قضية الـ «مايكروسيلتالايت»
+
+373
+00:36:05,820 --> 00:36:11,220
+variation و diversity وبتكون هيك ظواهر بتكون
+
+374
+00:36:11,220 --> 00:36:14,640
+موجودة بين البشر في أسئلة؟
+
+375
+00:36:23,650 --> 00:36:31,710
+بالنسبة لعلاقة الـ «جين»
+
+376
+00:36:31,710 --> 00:36:38,970
+مع الطواهر اللي حكيناها هو برضه hypothetical، يعني
+
+377
+00:36:38,970 --> 00:36:46,460
+نظرية أو افتراضيةإذا عندي أنا هذه الأشياء الأصلي
+
+378
+00:36:46,460 --> 00:36:53,400
+طبعاً هنا إحنا الـReference Sequence اللي أنا بدأت
+
+379
+00:36:53,400 --> 00:37:00,000
+فيه وهنا هذولة الـTwo copies تبعات الـDNA في One
+
+380
+00:37:00,000 --> 00:37:03,500
+Allele يعني هذه الجهة واحدة مش زي الصور اللي قبل
+
+381
+00:37:03,500 --> 00:37:09,040
+شوية كنا نحكي عن Two Alleles فهنا إذا حكينا إنه
+
+382
+00:37:09,040 --> 00:37:11,960
+أنا صار عندي Substitution Single Nucleotide
+
+383
+00:37:11,960 --> 00:37:17,730
+Polymorphismمثلًا في المنطقة هذه بحيث أنه صار عندى
+
+384
+00:37:17,730 --> 00:37:26,210
+بدل ما هي البقية كله بالترتيب صار هنا CGC بدل TA
+
+385
+00:37:26,210 --> 00:37:35,550
+بهذه الطريقة فهي ممكن تعتبر ظاهرة وهي راح يكون أن
+
+386
+00:37:35,550 --> 00:37:40,580
+كل هذا القطعة راح تغير الـNucleotide تبعهاوبالتالي
+
+387
+00:37:40,580 --> 00:37:49,780
+قد يعني تؤشر لـMinor asset ثاني وتعمل substitution
+
+388
+00:37:49,780 --> 00:37:55,300
+وتغير، بس أحيانا قد لا تغير، نصير عنده deletion
+
+389
+00:37:56,930 --> 00:38:03,990
+ماشي، ماشي، ماشي،
+
+390
+00:38:03,990 --> 00:38:07,430
+ماشي،
+
+391
+00:38:07,430 --> 00:38:13,050
+ماشي، ماشي، ماشي، ماشي، ماشي، ماشي، ماشي، ماشي،
+
+392
+00:38:13,050 --> 00:38:13,750
+ماشي، ماشي، ماشي، ماشي، ماشي، ماشي، ماشي، ماشي،
+
+393
+00:38:13,750 --> 00:38:14,670
+ماشي، ماشي، ماشي، ماشي، ماشي، ماشي، ماشي، ماشي،
+
+394
+00:38:14,670 --> 00:38:14,690
+ماشي، ماشي، ماشي، ماشي، ماشي، ماشي، ماشي، ماشي،
+
+395
+00:38:14,690 --> 00:38:14,690
+ماشي، ماشي، ماشي، ماشي، ماشي، ماشي، ماشي، ماشي،
+
+396
+00:38:14,690 --> 00:38:14,690
+ماشي، ماشي، ماشي، ماشي، ماشي، ماشي، ماشي، ماشي،
+
+397
+00:38:14,690 --> 00:38:24,990
+ماشي، ماشي، ماشي، ماشي،
+
+398
+00:38:25,390 --> 00:38:33,290
+دولة أمثلة من التفرات اللي ممكن تحدث لما
+
+399
+00:38:33,290 --> 00:38:38,970
+نيجي ندرس بالنسبة للأمراض الوراثية والحالات
+
+400
+00:38:38,970 --> 00:38:42,890
+الوراثية اكتشفنا بعدين إنه مسؤول عن كتير من
+
+401
+00:38:42,890 --> 00:38:52,650
+الظواهر اللي بنشوفها فلو جينا مثلًا ندرس أمراض
+
+402
+00:38:52,650 --> 00:38:57,920
+وحالات قديعني بعرف الواحد بعض منكم بعض المصابين
+
+403
+00:38:57,920 --> 00:39:03,560
+بهذه الحالات بس هي فكرة عشان نعطينا مؤشر كم مثل
+
+404
+00:39:03,560 --> 00:39:10,430
+هيك التفرات شائعة أو كم موجودة أو كممتوقعة أنها
+
+405
+00:39:10,430 --> 00:39:17,130
+تكون موجودة طبعاً هذه حسب دراسات معينة في يعني
+
+406
+00:39:17,130 --> 00:39:22,830
+populations معينة في بلاد معينة بين البيض، بين
+
+407
+00:39:22,830 --> 00:39:28,390
+الصينيين، بين الأفارقة، بين كذا، بين كذا فكل
+
+408
+00:39:28,390 --> 00:39:34,110
+مجموعة يعني بيعطونا أيش الـ أيش النوعية المشكلة
+
+409
+00:39:34,110 --> 00:39:37,230
+اللي عندهافي الحالة الأولى اللي هي اسمها
+
+410
+00:39:37,230 --> 00:39:43,840
+Acondroplasiaماشي، اللي هي يعني نوع من التقزم
+
+411
+00:39:43,840 --> 00:39:48,980
+بتشوفوهم كثير بالتلفزيون وممكن ناس بتشوفوا مثلهم
+
+412
+00:39:48,980 --> 00:39:56,500
+بعض الناس بعرفوا ناس عندهم هذه المشكلة الشخص
+
+413
+00:39:56,500 --> 00:40:01,920
+بيكون هذا هو أخوه تقريبًا أكبر من أخوه هذا بس حجم
+
+414
+00:40:01,920 --> 00:40:08,250
+راسه طبيعي، حجم جسمه طبيعي، بس أطرافهقصيرة، طبعاً
+
+415
+00:40:08,250 --> 00:40:11,110
+الـ Upper limbs والـ Lower limbs وبيأثر على العمود
+
+416
+00:40:11,110 --> 00:40:17,180
+الفقري بعدين وبيعملهم مشاكل، ذكائهم طبيعييعني فيه
+
+417
+00:40:17,180 --> 00:40:22,380
+ممثلين كبار فيه أطباء عندهم أكندربلازيا فيه صور ده
+
+418
+00:40:22,380 --> 00:40:27,100
+بتشوفوا ففي حالة راح ناخدها وفي اسمها Case رقم 2
+
+419
+00:40:27,100 --> 00:40:34,520
+اسمه الـ «أكندربلازيا» الجينات اللي فيها مشاكل زي
+
+420
+00:40:34,520 --> 00:40:38,440
+ما انتوا بس ملاحظة حتى تكون واضحة عندكم اللي هي
+
+421
+00:40:38,440 --> 00:40:42,590
+إنه بيكون الجين حاطينه Capital LetterFibroblast
+
+422
+00:40:42,590 --> 00:40:49,450
+Growth Factor Receptor 3 FGFR3
+
+423
+00:40:49,450 --> 00:40:55,910
+هذا الـ «لوكاس» تبع الـD الجين وإيش البروتين
+
+424
+00:40:55,910 --> 00:41:01,860
+المكافئ له اللي راح يصير فيه الاختلالهو عبارة عن
+
+425
+00:41:01,860 --> 00:41:07,960
+«Fibroblast Growth Factor Receptor» عبارة عن يعني
+
+426
+00:41:07,960 --> 00:41:15,360
+هو بيصير اختلال في نمو العضل الـ… الـ… الـ… الـ…
+
+427
+00:41:15,360 --> 00:41:18,940
+الـepiphyseal plate اللي هي في العظام الطويل اللي
+
+428
+00:41:18,940 --> 00:41:23,420
+على الطرف اللي بتسبب نموه عند البلوغ ونموه من قبل
+
+429
+00:41:23,850 --> 00:41:28,830
+بتلاقيها في خلل فيها ما بتستجيب لعوامل التنشيط
+
+430
+00:41:28,830 --> 00:41:34,970
+بشكل حقيقي أو سليم فهذه الـ الـ يعني يمكن لما
+
+431
+00:41:34,970 --> 00:41:43,750
+ناخدها بشكل تفصيلي أكثر بتكون مثال على مرض يعني هو
+
+432
+00:41:43,750 --> 00:41:47,390
+«Tosomal Dominant»ستجد الـ Mendelian Inheritance
+
+433
+00:41:47,390 --> 00:41:52,030
+وهذا الجين وهذه البروتين المسؤول عن إنه طالع من
+
+434
+00:41:52,030 --> 00:41:57,830
+نتيجة الجين وهذه ستجعلنا المرض يسميها كندروبلازيا
+
+435
+00:41:57,830 --> 00:42:04,030
+والـ mutation rate 1.4 في 10 أوص ناقص خمسة يعني
+
+436
+00:42:04,030 --> 00:42:08,590
+حوالي 10 أوص ناقص خمسة يعني بدنا حوالي 100 ألف بني
+
+437
+00:42:08,590 --> 00:42:16,640
+آدم كل 1.4 يعني مثلا 140 ألف بني آدمبيطلع لي واحد
+
+438
+00:42:16,640 --> 00:42:23,300
+عنده هذه المشكلة ماشي بيقدّر الواحد عدد السكان في
+
+439
+00:42:23,300 --> 00:42:29,000
+البلد وهذا تقريبًا بهذه النسبة في حالات أخرى كثيرة
+
+440
+00:42:29,000 --> 00:42:33,340
+فيها هذا اسمه «دوشين مسكولر ديستروفي» عبارة عن برض
+
+441
+00:42:33,340 --> 00:42:40,200
+في ضعف العضلات فالـ «دوشين» هو النوعية الشديدة منه
+
+442
+00:42:40,200 --> 00:42:48,240
+في أنواع خف في ضعف العضلاتفهنا يعني بيحاولوا يمثله
+
+443
+00:42:48,240 --> 00:42:53,960
+بيسموه «Going Sign» كيف أنه الطفل أو الإنسان لما
+
+444
+00:42:53,960 --> 00:42:58,800
+يحاول يوقف بس كأنه بتسلق على نفسه زي ما يقوله يعني
+
+445
+00:42:59,140 --> 00:43:03,720
+حتى يعرف يطلع ويصير شوي شوي وما عندهوش قوة عضلات
+
+446
+00:43:03,720 --> 00:43:10,080
+يسويها المرض الثالث هذا X-linked recessive فيه مرض
+
+447
+00:43:10,080 --> 00:43:13,460
+ثالث اللي هو أنواع مختلفة Von Reclinhausen اللي هو
+
+448
+00:43:13,460 --> 00:43:18,720
+الـ Neurofibromatosis type 1 عبارة عن البروتينال
+
+449
+00:43:19,250 --> 00:43:26,990
+فكل واحدة منهم، فهناك دراسات متعددة لنسبة
+
+450
+00:43:26,990 --> 00:43:33,950
+تواجد، نسبة حدوث، نسبة حدوث
+
+451
+00:43:33,950 --> 00:43:39,620
+التفرق بالشكل اللي بتسبب بعدين المرضطبعًا يعني مثل
+
+452
+00:43:39,620 --> 00:43:44,740
+ما درست مثلًا بشكل معين هنا ممكن نلاقي نقول إن
+
+453
+00:43:44,740 --> 00:43:49,000
+المصاب هو المصاب يشيرلي على إن الإصابة نشأت مثلًا
+
+454
+00:43:49,000 --> 00:43:55,020
+في أم على الـ X-Chromosome بس هي لأن عندها Two
+
+455
+00:43:55,020 --> 00:43:58,820
+copies ماصارش معاها مرض وكان فقط حامل وبعدين
+
+456
+00:43:58,820 --> 00:44:05,190
+الأطفال الدكور بعضهم بيطلع عنده المرض يعنيفهذه
+
+457
+00:44:05,190 --> 00:44:12,670
+كلها أشياء يتم دراستها و... إذا بدنا نأخذ الـ
+
+458
+00:44:12,670 --> 00:44:16,570
+Mandela Inheritance تقريباً نتكلم على بالألاف،
+
+459
+00:44:16,570 --> 00:44:21,350
+عشرات الألاف من الأمراض ممكن تكون هناك اختلالها
+
+460
+00:44:21,350 --> 00:44:24,810
+لما
+
+461
+00:44:24,810 --> 00:44:34,110
+ندرس الأمراض الوراثيةباللاقي إنه إذا بقدر شو نسبة
+
+462
+00:44:34,110 --> 00:44:41,350
+حدوث نوعية معينة من الطفرات اللي تؤدي لهذه
+
+463
+00:44:41,350 --> 00:44:44,410
+الإشكالية
+
+464
+00:44:44,410 --> 00:44:50,900
+باللاقي إنه اللي هو بيسموه Miss Sense Mutationاللي
+
+465
+00:44:50,900 --> 00:44:57,040
+هي أنه يعني اللي بفهمها «Nucleotide Substitution»
+
+466
+00:44:57,040 --> 00:45:02,860
+ماشي، يعني هدول اللي هما الـSnaps الدرجة الأساسية
+
+467
+00:45:02,860 --> 00:45:08,940
+اللي هي أنه خمسين بالمية من الأمراض اللي من ديالية
+
+468
+00:45:08,940 --> 00:45:13,320
+إذا بتيجي بتشوف شو نوعية المشكلة اللي عندها،
+
+469
+00:45:13,320 --> 00:45:18,680
+بتلاقي كثير منها عبارة عنSingle-Nucleotide
+
+470
+00:45:18,680 --> 00:45:23,440
+Substitution بس بيخرّب الـ Amino Acid بيخرّب نتيجة
+
+471
+00:45:23,440 --> 00:45:28,860
+ذلك واضيفة البروتين وبالتالي بيصير عندك مرض ففي
+
+472
+00:45:28,860 --> 00:45:34,880
+أحياناً بتكون أنه الـ Single-Nucleotide
+
+473
+00:45:34,880 --> 00:45:40,700
+Substitution أدى إلى أنه اللي بيطلع هو بيقوله بدل
+
+474
+00:45:40,700 --> 00:45:48,550
+ما البروتين بيكون طويلبيجي مقطوش نصه ربعه جزء منه
+
+475
+00:45:48,550 --> 00:45:53,270
+عساسي كان Premature stop codon يعني بالصدفة الـ
+
+476
+00:45:53,270 --> 00:45:59,130
+Substitution كانت نتيجتها stop فبالتالي بوقف الـ
+
+477
+00:45:59,130 --> 00:46:03,950
+Transcription وبالتالي بطلع البروتين ناقص وبالتالي
+
+478
+00:46:03,950 --> 00:46:08,590
+مظيفته مش مظبوطة في أحيانًا الـ RNA Processing
+
+479
+00:46:08,590 --> 00:46:13,100
+Mutations يعنيفي أحيانًا اللي حكينا فيه Intron
+
+480
+00:46:13,100 --> 00:46:16,620
+وفيه Exon وبدنا نلف بطريقة معينة حتى نقطعها حتى
+
+481
+00:46:16,620 --> 00:46:22,860
+نعطي الـ Messenger RNA فأحيانًا الـ Mutation في
+
+482
+00:46:22,860 --> 00:46:30,980
+موقع خطير لهذه القضية بحيث أنه بنتج عنه أنه ما
+
+483
+00:46:30,980 --> 00:46:37,540
+بتمكن الـ RNA أن يتم نسخه لبروتين بشكل جيد وكويس
+
+484
+00:46:38,140 --> 00:46:44,860
+فهي تقريبًا نسب الأشياء بس الـ «سنب» صحيح راح ناخد
+
+485
+00:46:44,860 --> 00:46:49,560
+بعد شوية هي نسبها عالية ويمكن ما تكونش إلها قيمة
+
+486
+00:46:49,560 --> 00:46:53,560
+بس من الأمراض هي تمثل خمسين بالمية من الأشياء
+
+487
+00:46:53,560 --> 00:46:56,760
+المعروفة حاليًا بالنسبة للـ «ديليشن» والـ
+
+488
+00:46:56,760 --> 00:47:03,580
+«إنسيرشن» برضه لو one or twoراح يكون مشكلة كبيرة
+
+489
+00:47:03,580 --> 00:47:09,900
+فـDeletion تمثل 25% من الأمراض الوراثية اللي
+
+490
+00:47:09,900 --> 00:47:16,400
+بنعرفها الـMendelian وبتكون 25% لو كان على عدد
+
+491
+00:47:16,400 --> 00:47:22,680
+قليل، يعني one or two nucleotidesأو أربعة أو خمسة
+
+492
+00:47:22,680 --> 00:47:29,520
+المهم مش ثلاث ثلاث وضعفاته يمكن ما تأثرش كثير إنه
+
+493
+00:47:29,520 --> 00:47:36,300
+كوظيفة بشكل كامل على البروتين فهذه أنواع إذا بتكون
+
+494
+00:47:36,300 --> 00:47:41,460
+deletions وinsertions يعني النقطة اللي بدأ كل واحد
+
+495
+00:47:41,460 --> 00:47:46,950
+يتذكرها إنه تقريبًامن الأمراض الوراثية المندلية
+
+496
+00:47:46,950 --> 00:47:53,170
+نسبة 50% هي SNEP Single-Nucleotide Polymorphism
+
+497
+00:47:53,170 --> 00:47:58,070
+نتجت عنها Amino Acid Substitution يعني صار عندي
+
+498
+00:47:58,070 --> 00:48:04,730
+تغيير في الـ Amino Acid حيث أنه أنتج عنه المرض في
+
+499
+00:48:04,730 --> 00:48:10,070
+أنواع أخرى، طرق أخرى ممكن SNEP يؤدي لمشاكل وربع 25
+
+500
+00:48:10,070 --> 00:48:17,560
+% بتكوناللي هي بالأخير هون بيسموه «mis-sense» هاي
+
+501
+00:48:17,560 --> 00:48:24,720
+بتعتبروها «non-sense» أو إنه بتخرّب الـ الـ الـ
+
+502
+00:48:24,720 --> 00:48:29,180
+DNA كقراءة بحيث إنه بيبطّل يسيل الـ protein اللي
+
+503
+00:48:29,180 --> 00:48:33,860
+أنا مطلوب إني أعمله أحيانًا
+
+504
+00:48:36,190 --> 00:48:40,570
+يعني هناك طرق متعددة لكيف بيصير الـ Deletion أو
+
+505
+00:48:40,570 --> 00:48:44,490
+كيف بيصير الـ Insertion أو كيف شو اللي بيصير عندنا
+
+506
+00:48:44,490 --> 00:48:50,390
+وهذه أمثلة يعني جيد
+
+507
+00:48:50,390 --> 00:48:54,010
+الواحد يعني يكون على الطلاع عليها أو على الأقل حتى
+
+508
+00:48:54,010 --> 00:48:59,830
+يحاول يقرأ بعدين عنها يعني يكون مستوعب شو الكلام
+
+509
+00:48:59,830 --> 00:49:07,970
+اللي هوهنا الـ «Hemophilia» الـ «Hemophilia»
+
+510
+00:49:07,970 --> 00:49:14,910
+المعروف فيه على الـ X-Chromosome فالـ X-Chromosome
+
+511
+00:49:14,910 --> 00:49:19,410
+فيه عليه الـ «Hemophilia» هو «Factor 8» الـ «جين»
+
+512
+00:49:19,410 --> 00:49:23,450
+وبالتالي طبعًا الـ «Hemophilia» A لأنه فيه
+
+513
+00:49:23,450 --> 00:49:28,610
+«Hemophilia» B اللي هي «Factor 9» مش «Factor»
+
+514
+00:49:30,860 --> 00:49:39,720
+بتلاقي هنا أنه بسبب هنا أنه الأصل أنه أنا عندي 23
+
+515
+00:49:39,720 --> 00:49:52,020
+إكزون فعندي 22 إنترون بالنص ماشي فالنتيجة
+
+516
+00:49:52,020 --> 00:49:54,580
+يعني
+
+517
+00:49:55,340 --> 00:50:01,860
+احتمالية حدوث Loop معين في Silk أو حبل الـDNA
+
+518
+00:50:01,860 --> 00:50:10,600
+بيصير عندى عملية اختلال في ترتيب وفي يعني هنا صار
+
+519
+00:50:10,600 --> 00:50:19,880
+زي Loop وقلب في ترتيب الـIntrons والـExons اللي
+
+520
+00:50:19,880 --> 00:50:24,500
+موجودة لهذا الشيء الأصل أنا عندى A هنا البداية
+
+521
+00:50:25,670 --> 00:50:31,370
+وببدأ الـ Intro on 1، 2، 3، لحد 21، 22، وبعدين في
+
+522
+00:50:31,370 --> 00:50:36,010
+عندي Point ثانية عادة بتعمل مشكلة، وبعدين الـ23،
+
+523
+00:50:36,010 --> 00:50:40,710
+هيك الأصل ينقرأ، هيك الأصل يكون طبيعي، فنتيجة
+
+524
+00:50:40,710 --> 00:50:47,510
+الـLoop هذا اللي بحدث، فبصير عندي أنه بدل ما هو
+
+525
+00:50:47,510 --> 00:50:52,790
+يبدأ بواحد، بيبدأ 22، 21، بقراه هيك، وبعدين 23 آخر
+
+526
+00:50:52,790 --> 00:50:59,920
+شيء،فالأمر بالنسبة لمن يكون ترتيب الـ «بروتين» الـ
+
+527
+00:50:59,920 --> 00:51:06,040
+«جين» بهذا الشكل إنه خربان، ما بيفيدني مش هيعطيين
+
+528
+00:51:06,040 --> 00:51:12,300
+الـ «بروتين» اللازم وبالتالي بيعمل نقصان الـ
+
+529
+00:51:12,300 --> 00:51:18,020
+Plotting factor وبالتالي عملية النزف والمشاكل اللي
+
+530
+00:51:18,020 --> 00:51:22,800
+بيصيب عند الإنسان هذا مثال على حالة ومرض وشغل معين
+
+531
+00:51:22,800 --> 00:51:28,990
+بتكون إنهOkay، يعني بالأخير الكتل كلها موجودة حجم
+
+532
+00:51:28,990 --> 00:51:40,270
+الـDNA نفسه بس ترتيبه مختلف وغلط نفترض
+
+533
+00:51:40,270 --> 00:51:45,230
+إن أنا جبت أي واحد منا ودرست الـWhole Genome
+
+534
+00:51:45,230 --> 00:51:51,390
+Sequencing يعني الـWhole Genome Sequencing بذكر
+
+535
+00:51:51,390 --> 00:51:55,890
+مرة ثانيةلما عملناها من خلال الـ Human Genome
+
+536
+00:51:55,890 --> 00:52:03,610
+Project بدوا بالأخر القرن اللي فات أو من 2001 إلى
+
+537
+00:52:03,610 --> 00:52:08,370
+2003 لما نخلصوه اشترك فيه حوالي، يعني يقال حوالي
+
+538
+00:52:08,370 --> 00:52:14,150
+700، 800 مختبر في العالم ودفعوا مصاري كتير وطولوا
+
+539
+00:52:14,150 --> 00:52:20,230
+كتير وبيقرأوها كانوا بيقرأوها بشكل بطيء، الآن
+
+540
+00:52:20,690 --> 00:52:26,330
+التقنية بقول زي تقنية الكمبيوترات بتلاقي إنه
+
+541
+00:52:26,330 --> 00:52:33,790
+الأجهزة صارت أسرع بكثير وبقدرات عالية جداً فالآن
+
+542
+00:52:33,790 --> 00:52:37,930
+إذا حد بده يعمل Whole Genome Sequencing راح ناخد
+
+543
+00:52:37,930 --> 00:52:42,570
+عنه مرة ثانية بقدر أبعث حين الدم على المختبر اللي
+
+544
+00:52:42,570 --> 00:52:47,510
+بعملها يعني في الأردن تقريباً نتكلم تقريباً 600،
+
+545
+00:52:47,510 --> 00:52:52,520
+700 دينارالمختبرات العالمية بتعملها ومش أي مختبر
+
+546
+00:52:52,520 --> 00:52:57,160
+يعني عادة يا هولندا يا كوريا هذولا بيعتبروا عنا
+
+547
+00:52:57,160 --> 00:53:03,220
+شاطرين وبيحاولوا يبعثوا الدم له فالـ 9 مليارات الـ
+
+548
+00:53:03,220 --> 00:53:07,940
+Nucleotide اللي بيجيبوهن المعلومات هذه بدها تكون
+
+549
+00:53:07,940 --> 00:53:14,160
+على External Hard Disk يعني Two Terabytes فاهمين
+
+550
+00:53:14,160 --> 00:53:20,090
+علي؟بيدّك كمية تعتبر هائلة من المعلومات في الغالب
+
+551
+00:53:20,090 --> 00:53:25,890
+ما لهاش قيمة راح نتكلم عنها لما نقعدي أنا أفرض Any
+
+552
+00:53:25,890 --> 00:53:29,390
+individual genome will contain the following هذه
+
+553
+00:53:29,390 --> 00:53:37,110
+يعني أنا روحت مسكت بني آدم وأخد دمه وقريت الـ9
+
+554
+00:53:37,110 --> 00:53:44,250
+مليارات حرف في الـDNA تبعه وعندي إمكانية أقارن مع
+
+555
+00:53:45,000 --> 00:53:49,680
+الـ Reference Sequence
+
+556
+00:53:49,680 --> 00:53:58,160
+اللي أنا أخدته Baseline وبأجي بعمل المقارنة بقدر
+
+557
+00:53:58,160 --> 00:54:05,300
+إنه من هالـ 9 مليارات فيه حوالي من 5 إلى 10 مليون
+
+558
+00:54:05,300 --> 00:54:11,680
+Snap يعني هتلاقي ما يقل يعني لو جيت أخدت أنا
+
+559
+00:54:11,680 --> 00:54:16,820
+بالنسبة لأيقطعة ثانية أو لأي شخص اللي هو في الـ
+
+560
+00:54:16,820 --> 00:54:21,480
+Reference اللي بعتبره Reference مش أقل من خمس
+
+561
+00:54:21,480 --> 00:54:26,360
+لعشر، لأ ملايين Single Nucleotide Polymorphism
+
+562
+00:54:26,360 --> 00:54:34,480
+بلاقيهم منهم خمس وعشرين ألف لخمسين ألفاللي هو
+
+563
+00:54:34,480 --> 00:54:39,040
+الـRare Variance، الـMutations الخاصة والـSeen or
+
+564
+00:54:39,040 --> 00:54:42,560
+Not Seen في خمس بالمئة وقليل من 5% من
+
+565
+00:54:42,560 --> 00:54:49,280
+الـIndividuals Tested يعني حتى يعني هنا السؤال لما
+
+566
+00:54:49,280 --> 00:54:53,900
+أشوف أنا اختلاف زي هيكة دائماً هل هذا معناه أن هذا
+
+567
+00:54:53,900 --> 00:55:00,820
+مرض؟ هل هو حالة؟ هي عبارة عن كيف ترتيب الـDNA
+
+568
+00:55:00,820 --> 00:55:08,330
+موجود في هذا الإنسانماشي، فاللي بدأ نحكي أنه مش
+
+569
+00:55:08,330 --> 00:55:13,550
+يعني في أي واحد مننا راح يكون حوالي بالملايين من
+
+570
+00:55:13,550 --> 00:55:19,890
+خمس إلى عشر ملايين Snap اختلاف عن المصدر الأشياء
+
+571
+00:55:19,890 --> 00:55:29,070
+هذه كثيرة إذا شائعة وكلمة شائعة ماشي هي علمياً لما
+
+572
+00:55:29,070 --> 00:55:34,530
+نقول Polymorphismالـ Polymorphism لازم تكون موجودة
+
+573
+00:55:34,530 --> 00:55:39,350
+في أكتر من 1% من الناس عندما تكون موجودة في 1% من
+
+574
+00:55:39,350 --> 00:55:46,730
+الناس، بنقول عنها Polymorphism ماشي، إذا أقل من
+
+575
+00:55:46,730 --> 00:55:53,740
+وجودها بين البشرأقل من 1% بنعتبرها Variation أو
+
+576
+00:55:53,740 --> 00:55:59,380
+Mutations وبنعتبرها ما وصلت Polymorphism وإن كان
+
+577
+00:55:59,380 --> 00:56:02,820
+Polymorphism أو غيره ممكن إثنانهم يسببوا مرض يعني
+
+578
+00:56:02,820 --> 00:56:08,500
+فبتوقع الواحد من 25 ألف لـ50 ألف Rare Variant في
+
+579
+00:56:08,500 --> 00:56:15,440
+أي إنسان تقريبًا 75 محل New Base Pair Mutation Not
+
+580
+00:56:15,440 --> 00:56:21,820
+Detected in Parental Genomesيعني أي واحد مننا
+
+581
+00:56:21,820 --> 00:56:26,560
+متوقع ما هو الخلايا بدأت تنقسم بدأت تعيد بناء الـ
+
+582
+00:56:26,560 --> 00:56:33,400
+DNA البناء الـ DNA مش 100% يعني لا يمكن يخطئ فيه
+
+583
+00:56:33,400 --> 00:56:41,200
+نسبة خطأ كبيرة الإشعاع والكيمويات والأمراض
+
+584
+00:56:41,200 --> 00:56:46,940
+مرات وليش بيصير cancers وكذا لأنه بيتم إدخال طفرة
+
+585
+00:56:46,940 --> 00:56:51,620
+معينةالماد اللي بالذات إذا الواحد بتكلم عنه الـ
+
+586
+00:56:51,620 --> 00:56:58,220
+Autosome الـ Dominant طب إنسان ماعندوش بين أبواه
+
+587
+00:56:58,220 --> 00:57:05,560
+المرض السائد بدات الطفرة عنده هو فبالتالي في 75
+
+588
+00:57:05,560 --> 00:57:09,870
+expected new base pair mutationsما كانت ظاهرة عند
+
+589
+00:57:09,870 --> 00:57:18,190
+أب وأم الشخص، أي واحد مننا فيه «CMV» يعني قطعة
+
+590
+00:57:18,190 --> 00:57:23,210
+أكبر من الـ «DNA» بتم يعني إضافتها أو تكرارها
+
+591
+00:57:23,210 --> 00:57:29,770
+حوالي من 200 ألف لـ500 ألف Indels اللي هو
+
+592
+00:57:29,770 --> 00:57:34,610
+«إنسيرشن» أو «دوليشن» من واحد لخمسين base pair
+
+593
+00:57:34,610 --> 00:57:40,360
+varies by populationيعني إذا اتكلمنا من خمس ملايين
+
+594
+00:57:40,360 --> 00:57:47,880
+لعشر ملايين Snap منهم حوالي يعني أقل منهم بكثير
+
+595
+00:57:47,880 --> 00:57:53,460
+بتلاقي اللي هو الـInsertions والـDeletions بتخيل و
+
+596
+00:57:53,460 --> 00:57:58,620
+بقدر فيه ألف Deletions بكونوا
+
+597
+00:57:58,620 --> 00:58:07,230
+أصغر شويةفيه 150 In-Frame، In-Deletions لـ250
+
+598
+00:58:07,230 --> 00:58:11,330
+Shifts فيه
+
+599
+00:58:11,330 --> 00:58:18,350
+100 ألف لـ12 ألف Synonymous Snap من حوالي برضه 10
+
+600
+00:58:18,350 --> 00:58:26,010
+ألف Non-Synonymous Snap يعني الفكرة إنه أنا لما
+
+601
+00:58:26,010 --> 00:58:32,460
+أنا قاعد أخد أي واحد منها وأسوي له Whole Genome
+
+602
+00:58:32,460 --> 00:58:38,340
+Sequencing في الغالب، راح ألاحظ عدد كبير من
+
+603
+00:58:38,340 --> 00:58:45,320
+الاختلافات عن الـ Reference Range المصدر الرئيسي
+
+604
+00:58:45,320 --> 00:58:49,800
+أو المرجع الأساسي تبعنا ويكون فيه اختلافات كثيرة
+
+605
+00:58:49,800 --> 00:58:55,440
+حتى ممكن عن والدي ووالدتي وكل واحد مننا ربنا خالقه
+
+606
+00:58:55,440 --> 00:59:04,900
+بطريقة مميزة، سبحان الله في أسئلةيعني دكتورة
+
+607
+00:59:04,900 --> 00:59:13,500
+أسماء تسأل الأرقام الموجودة في الـ «سلايد» دي كتير
+
+608
+00:59:13,500 --> 00:59:17,060
+يعني مش قادر تستوعب أيش المطلوب فهو أيش المختصر أو
+
+609
+00:59:17,060 --> 00:59:21,620
+المطلوب من الـ «سلايد» اللي زي هيك؟ المختصر
+
+610
+00:59:21,620 --> 00:59:29,100
+المطلوب إنه إذا لو سألتها «كم نيكليوتايد موجود؟»
+
+611
+00:59:29,100 --> 00:59:33,790
+لما أنا أقراهمالمفروض تكلّي تقريبًا تسع مليارات أو
+
+612
+00:59:33,790 --> 00:59:37,630
+ثلاث مليارات، يعني ثلاثة في عشرة أقصد تسعة
+
+613
+00:59:37,630 --> 00:59:44,670
+نيكليوتيد، هيك الـWhole Genome تبع الإنسان فلمّا
+
+614
+00:59:44,670 --> 00:59:52,690
+أدرس أي بني آدم تقريبًا فيه من خمس لعشر ملايين
+
+615
+00:59:52,690 --> 00:59:59,520
+سنة، يعني هي أولهايعني هل طبعًا عشر ملايين، لو
+
+616
+00:59:59,520 --> 01:00:02,680
+افترضنا عشر ملايين يعني كدهش؟ يعني عشر أقوى
+
+617
+01:00:02,680 --> 01:00:07,580
+السبعة، صح؟ هذيك الثلاثة في عشر أقوى التسعة ففي
+
+618
+01:00:07,580 --> 01:00:18,380
+عشر أقوى السبعة تقريبًا من الـ… من الـ… من الـSNP
+
+619
+01:00:18,380 --> 01:00:27,530
+الفكرة أنه في عدد كبير من التفراتبعضها لإن 75
+
+620
+01:00:27,530 --> 01:00:33,490
+مثلًا مش موجودة عند الأباء يعني أي واحد منها
+
+621
+01:00:33,490 --> 01:00:38,570
+تقريبًا يعني إذا بدي رقمين إنه خمس لعشر ملايين
+
+622
+01:00:38,570 --> 01:00:45,790
+طفرة على مستوى Snip فهي عدد أقل عشرات الألاف، خمس
+
+623
+01:00:45,790 --> 01:00:52,910
+ألاف، ألفين قطع أكبر شوية، يعني الـSnip شائعماشي
+
+624
+01:00:52,910 --> 01:01:00,250
+الأشياء الثانية أقل وفي حوالي خمس وسبعين mutation
+
+625
+01:01:00,250 --> 01:01:05,570
+ما بتوقعها تكون موجودة في الأبوين وبتكون يعني هي
+
+626
+01:01:05,570 --> 01:01:11,990
+ظهرت في هذا الإنسان نشأت في هذا الإنسان ماشيباقية
+
+627
+01:01:11,990 --> 01:01:17,450
+الأرقام ما بدناها شيها ومش هدفي يعني هم هنا هذه
+
+628
+01:01:17,450 --> 01:01:20,950
+كلها زي ما أنتم شايفين بحطوا لك هنا أن الرقم
+
+629
+01:01:20,950 --> 01:01:25,150
+تقريب، الرقم تقريب، الرقم تقريب يعني مش عدد كبير،
+
+630
+01:01:25,150 --> 01:01:29,650
+هيك خلّيني أن أخذها، عدد كبير بس في حوالي بقدره
+
+631
+01:01:29,650 --> 01:01:34,870
+خمس وسبعين يعني عشر ملايين أو خمس ملايين Snap
+
+632
+01:01:34,870 --> 01:01:40,360
+تقريبًا وخمس وسبعين طفرة جديدة في أي واحد منهامش
+
+633
+01:01:40,360 --> 01:01:46,680
+موجودة في أحلام ماشي تفاصيل الرقم ما بديشي يعني
+
+634
+01:01:46,680 --> 01:01:53,240
+طبعاً مش منطق الواحد يحفظهم يعني مش شطائر فهذه
+
+635
+01:01:53,240 --> 01:02:01,940
+الجزء هذا اللي حكيناها اللي هو من المحاضرة اللي
+
+636
+01:02:01,940 --> 01:02:07,970
+عدناها لأن ماقدرناش نشوفها المرة اللي فاتتباللي هي
+
+637
+01:02:07,970 --> 01:02:17,930
+وصف ممكن
+
+638
+01:02:17,930 --> 01:02:24,090
+إعادة إيش، بس دقيقة شوية هو السؤال اللي جابته قبل
+
+639
+01:02:24,090 --> 01:02:28,790
+شوية، دكتور، خصوص الـ«سلايد» السابق نعمالفكرة أنا
+
+640
+01:02:28,790 --> 01:02:35,910
+ما بدي تحفظه رقم بقدر ما تكون عندك مفهوم المبدأ
+
+641
+01:02:35,910 --> 01:02:40,210
+تبع الموضوع، ماشي؟ والآن راح نيجي على برضه إشي
+
+642
+01:02:40,210 --> 01:02:47,250
+قريب منها اللي هي مبدأ إنه أنا كجينات
+
+643
+01:02:47,250 --> 01:02:53,810
+عددها كبير أنت أحيانًا بحاجة إنك تدرس الموضوع
+
+644
+01:02:59,180 --> 01:03:03,060
+على مستوى الـ Molecule على مستوى الـ One Single
+
+645
+01:03:03,060 --> 01:03:07,440
+Nucleotide Polymorphism هذا يعني واحد من التسع من
+
+646
+01:03:07,440 --> 01:03:11,890
+الثلاث مليارات، بدك تدور عليهممثلاً، يعني تقولّي
+
+647
+01:03:11,890 --> 01:03:16,450
+في البشرية كلها «مين عمّار، خالد، داود، هذا، شو
+
+648
+01:03:16,450 --> 01:03:21,610
+هو؟» لما تيجي تاخد كل البشر وبين أنك تقول عموم
+
+649
+01:03:21,610 --> 01:03:27,510
+البشر كلهم «شو بيصير فيهم؟» يعني فاهمين عليك؟ فهي
+
+650
+01:03:27,510 --> 01:03:33,290
+يعني هذه قضية بتكون، شو اسمه؟ يعني بتكون أحياناً
+
+651
+01:03:33,290 --> 01:03:37,770
+هيك أنه يكون عند الواحد تصور إلها مهم يعني، ماشي؟
+
+652
+01:03:37,770 --> 01:03:43,460
+تفاصيل، اختلالات، لأ، مابدناشراح نتكلم بعدين على
+
+653
+01:03:43,460 --> 01:03:48,520
+أمثلة عن إذات بعض الأمراض الوراثية حتى نوضح مبادئ
+
+654
+01:03:48,520 --> 01:03:57,680
+معينة، ماشي؟ في أسئلة ثانية؟
+
+655
+01:03:57,680 --> 01:04:04,040
+بقيت المعلومات هيك، يعني خلينا الواحد يكون فاهمها
+
+656
+01:04:04,040 --> 01:04:08,360
+بشكل سطحي، يعني كمبدأ، يعني بهمني الواحد يفهم
+
+657
+01:04:08,360 --> 01:04:18,170
+المبدأ، ماشي؟الفصل هذا راح نبدأ فيه فيه أسئلة كمان
+
+658
+01:04:18,170 --> 01:04:26,990
+يا دكتور أحمد؟ لحد الآن لا يا دكتور طيب، الآن مش
+
+659
+01:04:26,990 --> 01:04:34,290
+غلط الواحد يكون منتبه لإيش أنا أملك من أدوات حتى
+
+660
+01:04:34,290 --> 01:04:40,510
+أفهم إذا شكيت في عائلة عندهابحالة ويراثية أو مرض
+
+661
+01:04:40,510 --> 01:04:47,050
+ويراثي كيف أفحص الجينات
+
+662
+01:04:47,050 --> 01:04:51,730
+والـ DNA والـ Genome وكيف أنا بعمل وهذه بيسميها
+
+663
+01:04:51,730 --> 01:04:59,350
+Clinical Cytogenetics and Genome Analysis المثل
+
+664
+01:04:59,350 --> 01:05:06,300
+اللي حكيناها الآن الـ SNPوالـ Micro-satellite
+
+665
+01:05:06,300 --> 01:05:12,960
+array هدولة يعني أمثلة لأشياء أنا بقدر أسويهم بس
+
+666
+01:05:12,960 --> 01:05:20,160
+في عندي أدوات أخرى وده أنا شكيت أنه الحالة نتيجة
+
+667
+01:05:20,160 --> 01:05:24,960
+نوع آخر من الاختلالات في عندي بعض الأدوات الأخرى
+
+668
+01:05:24,960 --> 01:05:29,860
+مش غلط الواحد يعرفها الفكرة
+
+669
+01:05:29,860 --> 01:05:38,420
+أنهيعني الأساس إن الواحد، أنا بظن إن هذا slide مهم
+
+670
+01:05:38,420 --> 01:05:43,200
+كثير، ويعني،
+
+671
+01:05:43,200 --> 01:05:48,140
+خلّيني بس أشيل هذه،
+
+672
+01:05:48,140 --> 01:05:54,080
+مش راضي، بس ما في، طيب،
+
+673
+01:06:01,460 --> 01:06:04,920
+أنا بظن إن الـ «سلايد» هذا من أهم الأشياء الواحد
+
+674
+01:06:04,920 --> 01:06:12,760
+يكون فاهمه لما أنا بدي أو بفكر إنه فيه مشكلة على
+
+675
+01:06:12,760 --> 01:06:20,700
+مستوى الـ «كروموزوم» على مستوى الـ… على مستوى
+
+676
+01:06:20,700 --> 01:06:28,100
+العدد الكبير من قطعة الـDNA بحاجة إن أعمل الفحص
+
+677
+01:06:28,100 --> 01:06:32,660
+اللي بنسميه «Standard Karyotype»الـ Karyotyping
+
+678
+01:06:32,660 --> 01:06:42,800
+اللي هو قلتلكم بتجيب خلايا سواء دم ولا غيره بتعطي
+
+679
+01:06:42,800 --> 01:06:48,340
+مادة زي الـ Colchicine في الدواء اللي بيمنع تكوين
+
+680
+01:06:48,340 --> 01:06:54,720
+الـ Spindle Fiber فتقدرش الكروموزومات تنفصل لقطبين
+
+681
+01:06:54,720 --> 01:06:59,960
+في انقسام الخلية وبالتالي بتظل الكروموزومات بالنص
+
+682
+01:07:00,620 --> 01:07:05,980
+بتروح، بتوقف على طاولة عالية يعني كنا تقريبًا
+
+683
+01:07:05,980 --> 01:07:12,120
+ارتفاع متر ونص تلاثة أو أقل من ثلاثة بالخلايا اللي
+
+684
+01:07:12,120 --> 01:07:18,020
+بتكون، يعني أتأمل إذا كان فيه ثوان حتى لو تشوفوا
+
+685
+01:07:18,020 --> 01:07:24,580
+فيديو كيف بنعمل الـKaryotype هذا بتسقطها على
+
+686
+01:07:24,580 --> 01:07:32,100
+الـSlidesوبعدين بتصير عملية الصبغ للـ Chromosomes
+
+687
+01:07:32,100 --> 01:07:40,080
+وبيبين عندها الـ DNA بالشكل المضغوط اللي هو على
+
+688
+01:07:40,080 --> 01:07:46,220
+شكل الـ Chromosomes الـ 23 زوج اللي هو الـ 22
+
+689
+01:07:46,220 --> 01:07:52,910
+أتظامن والـ X والـ Yلما نعمل بهذه الطريقة بنكون
+
+690
+01:07:52,910 --> 01:07:56,310
+اللي هو «Standard Karyotyping» وبيكون بيسموه
+
+691
+01:07:56,310 --> 01:08:00,790
+«Routine Banding» يعني هذه طريقة حتى نعرف وراح
+
+692
+01:08:00,790 --> 01:08:04,470
+نشوف أمثلة كده بيكون شكل الأشي اللي بيطلع حقيقة
+
+693
+01:08:04,470 --> 01:08:10,550
+معانا وبيكون هاي لما أنا أشك أنه بيعندي مشكلة فيها
+
+694
+01:08:10,550 --> 01:08:13,290
+عدد يعني زي «Down Syndrome» «Turner» «Crime
+
+695
+01:08:13,290 --> 01:08:16,890
+Filter» أمراض زي هيك، بتلاقي أني بعمل هذه الطريقة
+
+696
+01:08:17,420 --> 01:08:22,800
+وهنا بيكون الـ… يعني ما في إمكانية إنه يتكلم عن
+
+697
+01:08:22,800 --> 01:08:27,260
+إشي متخصص «سنب» ومش «سنب» وكده، لأ إحنا ما بنتكلم
+
+698
+01:08:27,260 --> 01:08:32,940
+عن هذا الـBandage العادية بيعطينا عدد معين من الـ…
+
+699
+01:08:32,940 --> 01:08:36,960
+المطاقات
+
+700
+01:08:36,960 --> 01:08:42,970
+على الـChromosomeممكن أن أنا أحسن الموضوع شويه
+
+701
+01:08:42,970 --> 01:08:48,370
+لأعمل High-Resolution Banding يعني إذا أنا شكيت
+
+702
+01:08:48,370 --> 01:08:54,790
+طبعاً إحنا هنا هاي ثلاث مليارات Baseband اللي يعني
+
+703
+01:08:54,790 --> 01:08:59,450
+إحنا لما نحكي عن الكرموزومات والـDNA بشكل كلي بدنا
+
+704
+01:08:59,450 --> 01:09:04,710
+نتكلم على عدد كبير من الـNucleotides عشرة أو
+
+705
+01:09:04,710 --> 01:09:09,920
+ستسعة، ماشي؟لما بدي أدى أنا مثلا في بعض الأمراض
+
+706
+01:09:09,920 --> 01:09:14,460
+والحالات بتكون مربوطة باختلال في قطعة أصغر شوية
+
+707
+01:09:14,460 --> 01:09:20,900
+يعني هو أنا ثلاث ملايين لمليون Base Pair سواء
+
+708
+01:09:20,900 --> 01:09:30,700
+Deletion، Copy Increase، كذافهنا إذا بستخدم يعني
+
+709
+01:09:30,700 --> 01:09:38,740
+High 400 لـ 550 Band Stage أو 850 Band Stage تسموه
+
+710
+01:09:38,740 --> 01:09:42,980
+هنا High-Resolution Banding لما أنا أقرب على إنه
+
+711
+01:09:42,980 --> 01:09:49,260
+أنا بحاجة إنه أدرس إذا في بعض الأمراض نتيجة اختلال
+
+712
+01:09:49,260 --> 01:09:56,770
+بقطعة أكبر شوية من الـ… من الـDNAبدي أعمل High
+
+713
+01:09:56,770 --> 01:10:01,310
+-Resolution Banding راح نشوف بعض الصور بعدين في
+
+714
+01:10:01,310 --> 01:10:08,430
+أشياء بتكون لأ يعني بقدر أدرس على قطع أصغر شوية
+
+715
+01:10:08,430 --> 01:10:11,970
+Comparative Genome Hybridization أو الـFish
+
+716
+01:10:11,970 --> 01:10:19,290
+Analysis أو الحمد لله Chromosomal Microarray
+
+717
+01:10:19,290 --> 01:10:28,570
+الـFish راح نشوف صورتها كيفالـ Fluorescent Encyto
+
+718
+01:10:28,570 --> 01:10:34,450
+-Hybridization هيك الإختصار تبعتها وهنا يعني
+
+719
+01:10:34,450 --> 01:10:40,310
+قريباً صرنا ناخد زي الـ Microarray أنا بجيب قطعة
+
+720
+01:10:40,310 --> 01:10:47,070
+مكافئة لإيش أنا بديها وبالتالي بصير أدور عليها في
+
+721
+01:10:47,070 --> 01:10:52,730
+كل الـGenome وبشوفبعدين سواء بعمل Electrophoresis
+
+722
+01:10:52,730 --> 01:10:58,110
+بشوف كيف توزعتها شو أحجام القطع اللي موجودة فيها
+
+723
+01:10:58,110 --> 01:11:02,230
+ويكون هذا مؤشر على مرض معين، خلال معين، ظاهرة
+
+724
+01:11:02,230 --> 01:11:09,670
+معينة وإذا بدي أروح على تفصيل أدق، بدي أبدأ أعمل
+
+725
+01:11:09,670 --> 01:11:13,430
+Whole Genome Sequencing هذا اللي بكلف، يعني
+
+726
+01:11:13,430 --> 01:11:21,390
+الـKaryotype، يعنيبقدر يمكن 20، 30 دينار بيكفي
+
+727
+01:11:21,390 --> 01:11:27,070
+بيعملوه يعني عبارة عن جهد بشري وشوية مواد بسيطة
+
+728
+01:11:27,070 --> 01:11:35,030
+وصبغات وخلاص هنا النتيجة راح تكون يعني 9 مليارات
+
+729
+01:11:35,030 --> 01:11:42,730
+حرف ويعني العقدة مش المشكلة اللي هتعملها بس
+
+730
+01:11:42,730 --> 01:11:49,250
+الأجهزة بتعملها بس هاتميني دلّكعلى وين تدور، وماذا
+
+731
+01:11:49,250 --> 01:11:56,370
+يتدور، وما الخلل الموجود يعني هذه النقطة
+
+732
+01:11:56,370 --> 01:12:01,150
+فهنا increasing resolution يعني درجة التعقيد أكثر
+
+733
+01:12:01,150 --> 01:12:06,070
+من النظرة في الدراسة
+
+734
+01:12:06,070 --> 01:12:08,810
+وهكذا تكون ترتيب الأمور
+
+735
+01:12:12,270 --> 01:12:20,290
+بالنسبة لما نعمل كاريو تايب أنا بس بدي أفرجيكم هنا
+
+736
+01:12:20,290 --> 01:12:26,170
+هذه أقرب صورة يمكن هذه الصورة هيك ماشي هيك بيكون
+
+737
+01:12:26,170 --> 01:12:29,550
+شكل الكاريو تايب يعني هذه الـBands هيك عادة
+
+738
+01:12:29,550 --> 01:12:37,310
+بنلاقيها فلما أنا آجي أدرس الـ… الـ… الـIdiogram
+
+739
+01:12:37,310 --> 01:12:43,330
+ماشيالـ «G-banding pattern for human chromosomes
+
+740
+01:12:43,330 --> 01:12:46,950
+at metaphase with approximately 400 bands per
+
+741
+01:12:46,950 --> 01:12:53,310
+haploid» يعني بيكون هيك الترتيب الأمور مثلًا هذا
+
+742
+01:12:53,310 --> 01:12:58,010
+الـChromosome الأول بتبدأ من واحد من هون وبعدين
+
+743
+01:12:58,010 --> 01:13:03,030
+إيه بتصير نعطيه أقام وبتصير أي يعني أشياء تقريبًا
+
+744
+01:13:03,030 --> 01:13:12,290
+مصطلح عليهاوبتكون هيك شكلها لما قاعد أدرس أي كاريو
+
+745
+01:13:12,290 --> 01:13:16,550
+تايب بيعطيني هذه الأشياء ممكن إذا أنا عارف مثلا
+
+746
+01:13:16,550 --> 01:13:23,510
+«دا جورت سندروم» تبع المناعة،
+
+747
+01:13:23,510 --> 01:13:30,870
+ماشيفيه على كروموزوم 21 الـP تحت فيه بيصير إنه
+
+748
+01:13:30,870 --> 01:13:35,250
+«تخلص» بيصير إنه «تغيير» بيصير أندي خلل معين
+
+749
+01:13:35,250 --> 01:13:42,050
+بتعطيلي مشكلة فإذا أنا يعني مش عندي شك سريلياً
+
+750
+01:13:42,050 --> 01:13:48,050
+بموقع معين بمرض معين بحالة معينة بطلب الـKaryotype
+
+751
+01:13:48,050 --> 01:13:52,750
+وبخليه يدورلي على هل الـBand زي ما أنا شايفه هنا
+
+752
+01:13:52,750 --> 01:13:59,830
+مظبوطةهي الطبيعية المتوقعة ولا فيها اختلاف هنا الـ
+
+753
+01:13:59,830 --> 01:14:07,070
+«Chromosome 5» وهذه نستخدم صبغة ثانية فبتعطينا بل
+
+754
+01:14:07,070 --> 01:14:13,850
+يعني نطاقات أكثر فهذه ممكن أستخدمها علشان إذا برضه
+
+755
+01:14:13,850 --> 01:14:20,170
+في حالة ثانية بتلاقيني بحتاج إن أعملها بتفصيل أكثر
+
+756
+01:14:20,170 --> 01:14:28,080
+في موقع معينيعني الاختلافات وبعد شويه أظن واحدة
+
+757
+01:14:28,080 --> 01:14:37,020
+اللي هي 850 Band يعني طريقة بتكون بتعطيني أداء بس
+
+758
+01:14:37,020 --> 01:14:40,980
+هاي كلها أشياء يعني حتى أحدد شو المطلوب بدي يكون
+
+759
+01:14:40,980 --> 01:14:44,840
+حسب المرض، حسب الحالة، شو المعروف من قبل، وين
+
+760
+01:14:44,840 --> 01:14:51,530
+الخلل في مثل هذا المرض، وبالتالي بصير أدور عليهفيه
+
+761
+01:14:51,530 --> 01:14:56,050
+تقنية اسمها الـ Fluorescence in C-2 Hybridization
+
+762
+01:14:56,050 --> 01:15:06,610
+يعني أنا عندي الآن بتسير لمثلًا لأمراض نفترض مرض
+
+763
+01:15:06,610 --> 01:15:11,450
+خطير، مرض يعني
+
+764
+01:15:11,450 --> 01:15:17,250
+مثلًا مرعب مثلًا مرات بدا الواحد كمرض ورافي اللي
+
+765
+01:15:17,250 --> 01:15:23,100
+هو مثلًا نفترض إشي مرعبراح تاخدوا إشي اسمه
+
+766
+01:15:23,100 --> 01:15:27,340
+«Hunting Things Korea» عبارة عن مرض بيسبب شلل
+
+767
+01:15:27,340 --> 01:15:34,180
+رعاشي وبيسبب وفاة وبيسبب يعني وفاة سريعة بشلل
+
+768
+01:15:34,180 --> 01:15:40,940
+للأسف هو ساعد، يعني autosomal dominant وبيبدأ في
+
+769
+01:15:40,940 --> 01:15:47,640
+الناس على عمر الأربعين يعني عادة الأمراض الشديدة
+
+770
+01:15:47,640 --> 01:15:53,290
+بتلاقيها بتبدأ بشكل مبكروالطفل المصاب ما بيخلف، ما
+
+771
+01:15:53,290 --> 01:15:59,130
+بتزوج إنما هذا حالة يعني خطيرة إذا الواحد بيشوف
+
+772
+01:15:59,130 --> 01:16:02,650
+حدا من أهله عنده إياها وبتبدأ على عمر الأربعين
+
+773
+01:16:02,650 --> 01:16:09,890
+بيكون الواحد صار متجوز ومخلف وكده، فاللي راح يصير
+
+774
+01:16:09,890 --> 01:16:15,130
+إذا اكتشفت هذه الحالة إن الأقارب، الأولاد، البنات،
+
+775
+01:16:15,130 --> 01:16:18,050
+يصيروا كلهم مرعوبين طب أنا حامل هذا الجيل ولا مش
+
+776
+01:16:18,050 --> 01:16:24,780
+حامل هذا الجيل؟عندي يا ولا ماعنديش يا؟ فإذا عندي
+
+777
+01:16:24,780 --> 01:16:33,560
+نتيجة حالات من قبل، نتيجة دراسات من قبل الـ Prob
+
+778
+01:16:33,560 --> 01:16:42,560
+يعني قطعة صغيرة زي مفتاح زي لما نحن مثلًا إذا نشبه
+
+779
+01:16:42,560 --> 01:16:49,880
+الموضوع المرة الثالثة لما تعمل Google Searchقفة
+
+780
+01:16:49,880 --> 01:16:56,020
+نبكي من ذكرا حبيبا خلاص بحط هاي القطعة و بكون هاي
+
+781
+01:16:56,020 --> 01:17:00,520
+نفترض الـ Probe بهذا الشكل هي مؤشر على الإنسان
+
+782
+01:17:00,520 --> 01:17:06,360
+الطبيعي عشان القصيد الأصلية الطبيعية ولكن نفترض
+
+783
+01:17:06,360 --> 01:17:12,540
+للناس اللي عندهم مرض إنه يكون الـ Probe بشكل قفة
+
+784
+01:17:12,540 --> 01:17:18,480
+من ذكرا حبيباما جبش القطعة نبكي من ذكرة، يا عزيزي
+
+785
+01:17:18,480 --> 01:17:22,900
+لأنه انشطبط هذه القطعة أو النقطة الصغيرة فصار أنا
+
+786
+01:17:22,900 --> 01:17:31,280
+عندي في مفتاح آخر بقدر أستفيد منه أني أدرس على
+
+787
+01:17:31,280 --> 01:17:38,160
+الجين المصاب فباجي أنا تقنية الـFluorescence in
+
+788
+01:17:38,160 --> 01:17:49,030
+Cetohybridization هنا الحاطين اللي هوالـ 4Q12
+
+789
+01:17:49,030 --> 01:17:54,950
+Red Fluorescence هذا قطعة معينة مثلًا في الناس
+
+790
+01:17:54,950 --> 01:18:02,710
+الطبيعيين بتكون بهذا الشكل والـ 4Q31.1 بتكون
+
+791
+01:18:02,710 --> 01:18:09,750
+بتعطيني لون Green فباجي أنا بجيب خلايا العائلة
+
+792
+01:18:09,750 --> 01:18:15,830
+المطلوبة دراستهاومثلًا أنا استخدمت هدولة الأثنين
+
+793
+01:18:15,830 --> 01:18:21,830
+وبعدين هدولة الـ Fluorescence dye اللي هي الأصباغ
+
+794
+01:18:21,830 --> 01:18:26,270
+المشعة أو الأصباغ اللي
+
+795
+01:18:26,270 --> 01:18:32,710
+لها Fluorescence ماشي، بتصير تبين عندي بشكل أحمر
+
+796
+01:18:32,710 --> 01:18:39,710
+أو أخضر حسب اللي أنا موجود فطبعًا
+
+797
+01:18:39,710 --> 01:18:49,390
+هناالـ يعني تفاصيل الواحد إذا بده يفهم مثل هيك
+
+798
+01:18:49,390 --> 01:18:54,430
+صورة بده يقرأ بالتفصيل الدقيق الممل «شو الحالة؟»
+
+799
+01:18:54,430 --> 01:18:58,380
+«إيش كان البروب؟» «ليش أخدوها؟»من وين طلّعوا؟ شو
+
+800
+01:18:58,380 --> 01:19:03,000
+الـ «sensitivity» و«specificity»؟ يعني كم نثبت إنه
+
+801
+01:19:03,000 --> 01:19:07,700
+هذه الطفرة بهذا الشكل هي في المرض هذا حقيقة مؤشر
+
+802
+01:19:07,700 --> 01:19:15,160
+عليه ولا مش مؤشر عليه؟ يعني دايماً الفخصات عبارة
+
+803
+01:19:15,160 --> 01:19:21,060
+عن شيء أحياناً له تأثير شديد كتير كتير كتير يعني
+
+804
+01:19:21,060 --> 01:19:26,180
+إحنا سواء الآن كل كلامنا على فحص الـCOVID مثلاًما
+
+805
+01:19:26,180 --> 01:19:32,480
+فيش فحص في العالم COVID ولا حتى HIV ولا كذا 100%
+
+806
+01:19:32,480 --> 01:19:38,460
+في كل شيء يعني إنه لإن الفحص أحسن شيء لازم 100% من
+
+807
+01:19:38,460 --> 01:19:44,200
+المصابين الفحص يقولّي إن هذا مصاب وبنفضل يكون 100%
+
+808
+01:19:44,200 --> 01:19:47,560
+باللي غير مصابين يطلعلنا الفحص إن هذا غير مصاب
+
+809
+01:19:47,560 --> 01:19:51,380
+فهذه الظاهرة اللي بنسميها Sensitivity وSpecificity
+
+810
+01:19:51,380 --> 01:19:58,260
+هذه أمرا ما بتكون 100%الـ 99% بيكون مقبول بس ممكن
+
+811
+01:19:58,260 --> 01:20:03,240
+تكون تعطي مشكلة كبيرة الـ 1% اللي ماعندوش المرض
+
+812
+01:20:03,240 --> 01:20:08,220
+بتقوله عندك المرض بروح بنتحر يعني مرات إذا كانت
+
+813
+01:20:08,220 --> 01:20:14,440
+تسير لما يسمع إنه عنده حالة خطيرة، حالة مرض كده
+
+814
+01:20:14,440 --> 01:20:18,260
+فالصورة
+
+815
+01:20:18,260 --> 01:20:23,480
+هذه بتقولنا على إنه من الأدوات الموجودة عندنا لفحص
+
+816
+01:20:24,310 --> 01:20:32,110
+الوراثة وأحيانًا للتعامل مع التشخيص ضمن عيلة معينة
+
+817
+01:20:32,110 --> 01:20:37,530
+لمرض معين، لحالة معينة ويبدو الواحد يرجع لمراجع من
+
+818
+01:20:37,530 --> 01:20:43,890
+قبل ويكون فاهم شو الفحص اللي بعمله باجي بدور علشان
+
+819
+01:20:43,890 --> 01:20:52,430
+أقدر أشخص هل الطفرة اللي يعني المدللة على مرض معين
+
+820
+01:20:52,430 --> 01:20:59,460
+موجودة ولا غير مجموعةفيها سلاح فهذا اللي هو الـ
+
+821
+01:20:59,460 --> 01:21:03,800
+«تكنيك» اللي اسمه «Fish» «Plurescence in Cyto
+
+822
+01:21:03,800 --> 01:21:13,220
+-Hybridization» بفيدني إني أنا على مستوى من متوسط
+
+823
+01:21:13,220 --> 01:21:20,400
+الحساسية متوسط الدقة من ما بين الـ«Karyotype»
+
+824
+01:21:20,400 --> 01:21:23,850
+والـ«Whole Genome Sequencing»فهي يعني مبدأ أنا
+
+825
+01:21:23,850 --> 01:21:27,310
+بهمني أنه تكونوا فاهمينه قضية إنه أنا إذا كنت
+
+826
+01:21:27,310 --> 01:21:32,950
+أستخدم Micro-satellite أو Fish أو Probe أنا بدور
+
+827
+01:21:32,950 --> 01:21:39,030
+بطريقة بين إنه أدرس الـChromosome كله والجنوم كله
+
+828
+01:21:39,030 --> 01:21:45,190
+أو Whole-Genome Sequencing بكون درست بشكل دقيق
+
+829
+01:21:45,190 --> 01:21:53,710
+كثير إذا ما أخترت الأداء المناسبةيعني هنا حكينا ما
+
+830
+01:21:53,710 --> 01:21:58,730
+بعرفش كدهش كُلفة الـ… بس لما يكون فيه fluorescence
+
+831
+01:21:58,730 --> 01:22:03,890
+لهذا الشكل الجهاز، الميكروسكوب، غالي وكُلفته أكبر
+
+832
+01:22:03,890 --> 01:22:09,750
+أن يكون عندك المواد بتكون أثمن وأغلى إنك تجيبها
+
+833
+01:22:09,750 --> 01:22:13,150
+يعني تبعت الـKaryotype بقدر عشرين، ثلاثين، أربعين
+
+834
+01:22:13,150 --> 01:22:20,480
+دينار يعني maximum هدولة نتكلم على بالمئاتبس الـ
+
+835
+01:22:20,480 --> 01:22:24,220
+Whole Genome Sequencing أبقى أنا لأن بقدر تقريبًا
+
+836
+01:22:24,220 --> 01:22:29,380
+300، 700 دينار الأردني يعني هيك بيقولونها بس هنا
+
+837
+01:22:29,380 --> 01:22:34,660
+أغلب كتير من الـ Karyotype بس أحيانًا مفيدة
+
+838
+01:22:34,660 --> 01:22:42,500
+والواحد يكون حذر في قراءتها هنا برضه الـ Binding
+
+839
+01:22:42,500 --> 01:22:50,450
+تبع الـ X-Chromosomeوفيه Microarray برضه يعني
+
+840
+01:22:50,450 --> 01:23:01,050
+أساليب أخرى من المختبرات ممكن هنا يعني حاطين
+
+841
+01:23:01,050 --> 01:23:07,970
+Genomic Dosage يعني بالأخير هنا بدي يحاول يعطيني
+
+842
+01:23:07,970 --> 01:23:16,990
+كام نسبة أو عدد الـ Copies منإذا قطعة معينة من الـ
+
+843
+01:23:16,990 --> 01:23:24,910
+«DNA» بشكل معين ماشي، فالـ… يعني هاي أصبحنا نتكلم
+
+844
+01:23:24,910 --> 01:23:32,310
+على Microarray يعني أنا بستخدم هنا أداة بتقيص لي
+
+845
+01:23:32,310 --> 01:23:38,450
+مثلًا خمس، عشر تلاف ممكن تلفميت، أربعميت Nuclear
+
+846
+01:23:38,450 --> 01:23:44,910
+Base قطعة «DNA»وهنا هذه الـ «تكنيك» عشان أدرس كام
+
+847
+01:23:44,910 --> 01:23:49,530
+نسخة منها ففيها أحيانًا بيكون عندي «Loss» وأحيانًا
+
+848
+01:23:49,530 --> 01:23:54,570
+بيكون عندي «Gain» والـ «No Change» بيكون بدرجة
+
+849
+01:23:54,570 --> 01:24:00,270
+معينة هناك
+
+850
+01:24:00,270 --> 01:24:07,390
+يعني هذه كلها بنمشي عليها مابديش ندخل بتفاصيلها
+
+851
+01:24:08,000 --> 01:24:13,960
+ماشي التقنيات
+
+852
+01:24:13,960 --> 01:24:21,060
+كثيرة وكل ما الإنسان أو الصوان يعني أنا بتأمل إنه
+
+853
+01:24:21,060 --> 01:24:25,840
+زي الجامعة الإسلامية في قصة أو في خيره يمكن
+
+854
+01:24:25,840 --> 01:24:32,640
+الجامعة الإسلامية على يعني إنه
+
+855
+01:24:32,640 --> 01:24:38,370
+الواحد يضع موارد ماليةلمجتمع حتى نجيب كل الأجهزة
+
+856
+01:24:38,370 --> 01:24:45,930
+وكل الآلات مش ضروري، ماشي؟ فإذا تكلمنا هنا الـ
+
+857
+01:24:45,930 --> 01:24:50,110
+Incidence of chromosomal anomalies in newborn
+
+858
+01:24:50,110 --> 01:25:00,890
+surveys لحوالي 70 ألف newborn، هي دراسة في هنا
+
+859
+01:25:00,890 --> 01:25:08,110
+يعني ملاحظ في دراسة هنا على 70 ألفولادة طبيعية،
+
+860
+01:25:08,110 --> 01:25:16,110
+يعني بالأخير الجنين وصل إنه ولد، ماشي أحياناً فيه
+
+861
+01:25:16,110 --> 01:25:21,410
+دراسات كنت أشوفها بيحطوا تقدير نسبة حدوث الطفرات
+
+862
+01:25:21,410 --> 01:25:29,190
+في اللي هم حتى الـStill Birth أو حتى الـAbortions
+
+863
+01:25:29,190 --> 01:25:34,990
+أو حتى اللي بتكون فيه الجهاديعني بتكون إنه نتيجة
+
+864
+01:25:34,990 --> 01:25:44,630
+المشكلة شو اسمه؟ بتلاقي فيه عندنا نسبة أعلى منهم
+
+865
+01:25:44,630 --> 01:25:48,680
+يعني فيه دراسات بتكون تشمل مش بس الـNewportفاللي
+
+866
+01:25:48,680 --> 01:25:55,820
+بده يفرجيه بس كملاحظة ومرة ثالثة مش مطلوب الواحد
+
+867
+01:25:55,820 --> 01:26:01,260
+يحفظ الرقم هذا شيء موجود في أحد الـ «رفيرانس» من
+
+868
+01:26:01,260 --> 01:26:06,240
+دراسة معينة يعني مش قرآن منزل بقدر ما أنه هو
+
+869
+01:26:06,240 --> 01:26:11,360
+تقديري وتقريبي ويمكن الله العليم إذا الواحد يشوف
+
+870
+01:26:11,360 --> 01:26:14,960
+كم من النسب تعطيه فكرة فـ
+
+871
+01:26:17,610 --> 01:26:26,390
+بالنسبة لفي حوالي 70 ألف ولاد وصلت الشهر التاسع
+
+872
+01:26:26,390 --> 01:26:32,290
+وولد الطفل بنلاقي إنه All chromosomal anomalies
+
+873
+01:26:32,290 --> 01:26:43,870
+تقريبًا 1 على الـ145 يعني حطين تقريبًا 0.6%يعني
+
+874
+01:26:43,870 --> 01:26:50,930
+تقريبًا كل 200، هنا 150 جنين يولد واحد بيكون عنده
+
+875
+01:26:50,930 --> 01:26:57,330
+خلل ما اسمه؟ في الـ «كروموزومات» على مستوى الـ
+
+876
+01:26:57,330 --> 01:27:05,890
+«كروموزومات» إنه في بعضهم عبارة عن اختلال في العدد
+
+877
+01:27:05,890 --> 01:27:17,910
+«انيبلويدي» يعني سواء يعنيحذف أو إضافة أو زيادة أو
+
+878
+01:27:17,910 --> 01:27:23,510
+كذا بتلاقي بالذات الـ X والـ Y كرموزومات هي أكتر
+
+879
+01:27:23,510 --> 01:27:29,630
+شيء فيها الشغل يدي طبعاً رقم واحد Unemployed يعني
+
+880
+01:27:29,630 --> 01:27:35,990
+كاختلال كمان الـ Down Syndrome وغيره واحد
+
+881
+01:27:35,990 --> 01:27:40,430
+بالسبعمية بيكون في الـ Autosomal chromosomesوفيه
+
+882
+01:27:40,430 --> 01:27:44,390
+Structural Abnormalities الـ Structural
+
+883
+01:27:44,390 --> 01:27:50,610
+Abnormality المقصود فيها إنه، Okay كعدد الكرمزومات
+
+884
+01:27:50,610 --> 01:27:56,230
+سليم ومظبوط بس فيه اختلالات في التركيب وراح ناخد
+
+885
+01:27:56,230 --> 01:28:01,910
+بعض من بعض إنه مرات يكون عندي نقل من قطعة لقطعة
+
+886
+01:28:01,910 --> 01:28:06,670
+بحيث إنه المحصقة بتكون يا أما Balanced في الحالة
+
+887
+01:28:06,670 --> 01:28:10,270
+هذه مايكونش فيه مشكلة في هذا الفرقأو Unbalanced،
+
+888
+01:28:10,270 --> 01:28:15,070
+بالتالي بتكون مشكلة كبيرة بالذات في قضية الخلف
+
+889
+01:28:15,070 --> 01:28:19,030
+بعدين وإنه ممكن تنتقل للجيل اللي بعده وتعطينا مرض
+
+890
+01:28:19,030 --> 01:28:28,270
+شديد فتقريبًا واحد كل 150 جنين طفل يولد بيكون
+
+891
+01:28:28,270 --> 01:28:31,850
+متوقع إن واحد عنده نوع من الاختلال في
+
+892
+01:28:31,850 --> 01:28:37,570
+الـChromosomes وهي درجة عالية كثيرأحنا اللي
+
+893
+01:28:37,570 --> 01:28:41,910
+اتكلمنا قبل شوية عنه اللي هي مواضيع أمراض اللي
+
+894
+01:28:41,910 --> 01:28:46,870
+بنعتبرها طفرات على مستوى الـNucleotide يعني على
+
+895
+01:28:46,870 --> 01:28:50,850
+مستوى إشي دقيق كثير لما أن هنا أحنا قطعة
+
+896
+01:28:50,850 --> 01:28:54,390
+الـChromosome الكبير هذه عادة لازم تكون Balanced
+
+897
+01:28:54,390 --> 01:29:04,190
+حتى الإنسان يظل عايش يعني لما نحكي المصطلحات
+
+898
+01:29:04,380 --> 01:29:10,160
+يعني احنا فيه كمان بنبّه راح نتفرج بعدين على اللي
+
+899
+01:29:10,160 --> 01:29:15,600
+بيسموه الـ «family
+
+900
+01:29:15,600 --> 01:29:19,120
+pedigree» يعني اللي هي شجرة العيلة كيف نرسمها؟ كيف
+
+901
+01:29:19,120 --> 01:29:23,500
+نقراها؟ شو المعلومات اللي بدنا نحطها؟ كل ما الواحد
+
+902
+01:29:23,500 --> 01:29:31,080
+يشوف حالة لازم كطبيب حتى يعني يوثّق الحالة ويكون
+
+903
+01:29:31,080 --> 01:29:35,850
+مدعا أكبر للنشرويكون الناس تفق في المعلومة اللي
+
+904
+01:29:35,850 --> 01:29:39,750
+بذكرها لازم على طول يرسم الـ Pedigree تبع العائل
+
+905
+01:29:39,750 --> 01:29:43,830
+وفي نفس الوقت، لما واحد يشتغل الشغل تبع
+
+906
+01:29:43,830 --> 01:29:48,550
+الـSequencing أو الـKaryotype أو الأشياء التانية،
+
+907
+01:29:48,550 --> 01:29:52,610
+الـMicroarrays أو الـFish أو غيره، بده يستخدم
+
+908
+01:29:52,610 --> 01:29:55,850
+المصطلحات المتفق عليها بالطريقة المتفق عليها
+
+909
+01:29:55,850 --> 01:30:00,430
+فالـSyn، «سينترومير»، «دل»، «دليشن»، طبعاً
+
+910
+01:30:00,430 --> 01:30:05,920
+الـExample لما نقول احنالـ Karyotype 46XX هذا الـ
+
+911
+01:30:05,920 --> 01:30:10,140
+Normal Female Karyotype الـ 46XY Normal Male
+
+912
+01:30:10,140 --> 01:30:13,800
+Karyotype «سنترومير»، «سنترومير»، «سنترومير»،
+
+913
+01:30:13,800 --> 01:30:14,500
+«سنترومير»، «سنترومير»، «سنترومير»، «سنترومير»،
+
+914
+01:30:14,500 --> 01:30:15,720
+«سنترومير»، «سنترومير»، «سنترومير»، «سنترومير»،
+
+915
+01:30:15,720 --> 01:30:16,560
+«سنترومير»، «سنترومير»، «سنترومير»، «سنترومير»،
+
+916
+01:30:16,560 --> 01:30:18,620
+«سنترومير»، «سنترومير»، «سنترومير»، «سنترومير»،
+
+917
+01:30:18,620 --> 01:30:22,780
+«سنترومير»، «سنترومير»، «سنترومير»، «سنترومير»،
+
+918
+01:30:22,780 --> 01:30:30,120
+«سنترومير»، «سنترومير
+
+919
+01:30:30,850 --> 01:30:34,530
+الـ Short Arm of Chromosome يعني هذه المصطلحات
+
+920
+01:30:34,530 --> 01:30:41,610
+اللي «Gain» أو «Loss» أو «Mosaicism» المزاييك يعني
+
+921
+01:30:41,610 --> 01:30:46,970
+إنه فيه أكتر من شكل في نفس الإنسان، ماشي؟ فهدولة و
+
+922
+01:30:46,970 --> 01:30:50,670
+الـ Translocation و الـ Robert Stahnel
+
+923
+01:30:50,670 --> 01:30:53,170
+Translocation Ring Chromosomes
+
+924
+01:30:55,720 --> 01:31:03,100
+يعني هذه أمثلة على بعض المصطلحات أو الأختصارات
+
+925
+01:31:03,100 --> 01:31:09,300
+المستخدمة حتى الواحد لما يقرا بعدين أو يشوف الـP
+
+926
+01:31:09,300 --> 01:31:14,440
+short arm of the chromosome الـQ long arm of the
+
+927
+01:31:14,440 --> 01:31:18,460
+chromosome الـPaternal origin الـMaternal اللي من
+
+928
+01:31:18,460 --> 01:31:24,970
+الأم أو من الأب إذا بيفرق من وين أجت القطعةويعني
+
+929
+01:31:24,970 --> 01:31:31,470
+هنا هم عاملين «Karyotype» على «Fish» على
+
+930
+01:31:31,470 --> 01:31:36,450
+«Microarray Study» بتلاقي أحيانًا في دراسة حالة
+
+931
+01:31:36,450 --> 01:31:41,230
+معينة بيحطلك رسمات فيها أشياء زي هيك، ماشي
+
+932
+01:31:44,890 --> 01:31:51,270
+حكينا في أحيانًا يصير عندي الـNon-disjunction هنا
+
+933
+01:31:51,270 --> 01:31:57,090
+حاطين أو عملية الـTranslocation أو Isochromosome
+
+934
+01:31:57,090 --> 01:32:01,290
+أو Troperstein Translocation أو كذا، Duplication
+
+935
+01:32:01,290 --> 01:32:09,790
+يعني هدولة كلهم اختلالات على مستوى الـDNA ممكن
+
+936
+01:32:09,790 --> 01:32:15,730
+الانتباه إلها من خلال الـKaryotypeممكن عن طريق
+
+937
+01:32:15,730 --> 01:32:21,250
+الـFish أو أشياء أقل، بس يعني هاي لإنك تحاول تعمل
+
+938
+01:32:21,250 --> 01:32:27,030
+Sequencing ما لها معنى، ماشي؟ بدك تشوف، فطبعاً
+
+939
+01:32:27,030 --> 01:32:33,730
+أهمية هذه النقاط إذا كانت Balanced نفس الإنسان
+
+940
+01:32:33,730 --> 01:32:42,790
+بيكون يعني طبيعي، عنده التقم كامل من الجينات، تقم
+
+941
+01:32:42,790 --> 01:32:48,490
+كامل من الـمن المادة الوراثية وبالتالي ما عندهوش
+
+942
+01:32:48,490 --> 01:32:54,170
+هو مشكلة لأن اللي عنده Balance أما لما يكون نتيجة
+
+943
+01:32:54,170 --> 01:33:00,850
+بعدين في محاولة يعني قطعة كورموزوم معير انتقلت من
+
+944
+01:33:00,850 --> 01:33:05,610
+طبقة من محل لمحل فاللي بيصير أنه اللي انتقلت منه
+
+945
+01:33:05,610 --> 01:33:10,140
+راح يصير أقصر ويصير ناقصواللي فيها زيادة عنده
+
+946
+01:33:10,140 --> 01:33:14,840
+نسختين أحيانًا نسختين مهمات فلو عند الواحد نسختين
+
+947
+01:33:14,840 --> 01:33:19,560
+ولو إنه مع نفس المحل بس بيمشي الحال فهسة لما ييجي
+
+948
+01:33:19,560 --> 01:33:25,240
+هو يتزوج ويريد يخلف بتلاقي إذا كانت النسقة هي اللي
+
+949
+01:33:25,240 --> 01:33:30,860
+فيها نقص راح يصير إن هذا الجنين لن يعيش إذا كانت
+
+950
+01:33:30,860 --> 01:33:38,110
+الجميت في الإشي اللي فيه نقص فـودا أوقف هنا ونبدأ
+
+951
+01:33:38,110 --> 01:33:40,970
+في هذا الـ «سلايد» الأسبوعي في المحاضرة القادمة،
+
+952
+01:33:40,970 --> 01:33:46,570
+ان شاء الله في أسئلة؟ لحد الآن يعني الموضوع تمام،
+
+953
+01:33:46,570 --> 01:33:49,750
+إذا كانت في أسئلة يا دكاترة بإمكانك تسأله سواء
+
+954
+01:33:49,750 --> 01:33:53,730
+بخصوص المحاضرة هذا أو المحاضرة الماضية كمان إن شاء
+
+955
+01:33:53,730 --> 01:34:00,170
+الله المرات القادمة راح طلعت على «كاب لان» وعلى
+
+956
+01:34:00,170 --> 01:34:05,890
+الـUSMLE والله يعني في أشياء لسه ما أخذنهاشبس إنه
+
+957
+01:34:05,890 --> 01:34:09,930
+الواحد يقعد يراجعهم مش غلط
+وهيصير جزء من الإعداد
+
+958
+01:34:09,930 --> 01:34:16,690
+للامتحانات إنه نراجعها يعنيبإذن الله، بإذن الله
+
+959
+01:34:16,690 --> 01:34:21,890
+لأنه، لأنه يا دكتور يعني حتى توجهه لكلية إنه تم
+
+960
+01:34:21,890 --> 01:34:25,130
+اعتماد وإقرار امتحان «IPhone Basic Science» المهم
+
+961
+01:34:25,130 --> 01:34:30,630
+الواحد يكون فاهم المبدأ أو الشيء جيد، جيد إن
+
+962
+01:34:30,630 --> 01:34:35,330
+الطلاب على اللي هو السياحة تبع الامتحان من الآن
+
+963
+01:34:35,330 --> 01:34:41,070
+نبدأ نراجعها، بس بديش يعني في أحيانًا إجابة
+
+964
+01:34:41,070 --> 01:34:46,190
+الأسئلة يمكنبتكون أقدر على إنك مع نهاية الـ
+
+965
+01:34:46,190 --> 01:34:49,970
+«course» تدرسها تكون مريت عليها يعني بتكون أحيانًا
+
+966
+01:34:49,970 --> 01:34:54,150
+أن أنت الآن شغل أنت ما أخدت راح تاخده بعدين يعني
+
+967
+01:34:54,150 --> 01:35:00,130
+كمثال محدد لنوع مرض ورافي يعني مثلًا، فاهم عليك؟
+
+968
+01:35:00,130 --> 01:35:04,270
+آه تمام، إن شاء الله، بإذن الله تعالى الله يوفقكم،
+
+969
+01:35:04,270 --> 01:35:08,010
+نشوفكم الأسبوع القادم، إن شاء الله، يلا السلام
+
+970
+01:35:08,010 --> 01:35:09,010
+عليكم يعطيك العافية دكتور
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/nm86yn-CITA_raw.json b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/nm86yn-CITA_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..2aaf267454feb905004a48aaca2ff945aadfb7e7
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/nm86yn-CITA_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 2850, "start": 0.0, "end": 28.5, "text": "بالنسبة لـ «عشان نربط الأمور ببعض» أتأمل الجدول هذا يكون موجود، شايفينه يعني كمرض، وكنوع من الأمراض الوراثية الـsickle cell والثلاثيميا، أنيميا البحر الأبيض المتوسط", "tokens": [3555, 6027, 1863, 35457, 3660, 5296, 39184, 4657, 3615, 8592, 7649, 8717, 25513, 9566, 16247, 2304, 13063, 4724, 3555, 3615, 11242, 5933, 5551, 2655, 10721, 42213, 25724, 3215, 12610, 23758, 7251, 30544, 3714, 29245, 23328, 12399, 13412, 995, 33911, 9957, 3224, 37495, 22653, 9122, 29973, 11242, 12399, 4032, 4117, 1863, 45367, 9154, 16247, 29973, 46958, 2423, 13063, 5718, 104, 10632, 2423, 39184, 82, 618, 306, 2815, 16070, 12984, 1211, 5718, 104, 32640, 25528, 12399, 14739, 32640, 25528, 29739, 5016, 2288, 16247, 21292, 11242, 9673, 2655, 41779, 9566], "avg_logprob": -0.1740944595499472, "compression_ratio": 1.5891891891891892, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 0.0, "end": 0.54, "word": "بالنسبة", "probability": 0.8619140625}, {"start": 0.54, "end": 1.12, "word": " لـ", "probability": 0.724609375}, {"start": 1.12, "end": 3.68, "word": " «عشان", "probability": 0.8465576171875}, {"start": 3.68, "end": 4.1, "word": " نربط", "probability": 0.9679361979166666}, {"start": 4.1, "end": 4.56, "word": " الأمور", "probability": 0.9943033854166666}, {"start": 4.56, "end": 6.2, "word": " ببعض»", "probability": 0.80205078125}, {"start": 6.2, "end": 7.6, "word": " أتأمل", "probability": 0.75799560546875}, {"start": 7.6, "end": 8.84, "word": " الجدول", "probability": 0.89013671875}, {"start": 8.84, "end": 9.24, "word": " هذا", "probability": 0.91796875}, {"start": 9.24, "end": 9.84, "word": " يكون", "probability": 0.985107421875}, {"start": 9.84, "end": 10.84, "word": " موجود،", "probability": 0.9095458984375}, {"start": 10.84, "end": 12.14, "word": " شايفينه", "probability": 0.9486328125}, {"start": 12.14, "end": 15.24, "word": " يعني", "probability": 0.830322265625}, {"start": 15.24, "end": 18.54, "word": " كمرض،", "probability": 0.8275146484375}, {"start": 18.54, "end": 22.34, "word": " وكنوع", "probability": 0.9339599609375}, {"start": 22.34, "end": 22.56, "word": " من", "probability": 0.99560546875}, {"start": 22.56, "end": 23.06, "word": " الأمراض", "probability": 0.9920247395833334}, {"start": 23.06, "end": 24.28, "word": " الوراثية", "probability": 0.97890625}, {"start": 24.28, "end": 25.2, "word": " الـsickle", "probability": 0.756640625}, {"start": 25.2, "end": 25.48, "word": " cell", "probability": 0.830078125}, {"start": 25.48, "end": 26.6, "word": " والثلاثيميا،", "probability": 0.734100341796875}, {"start": 26.6, "end": 27.02, "word": " أنيميا", "probability": 0.66015625}, {"start": 27.02, "end": 27.4, "word": " البحر", "probability": 0.9200846354166666}, {"start": 27.4, "end": 27.72, "word": " الأبيض", "probability": 0.7964680989583334}, {"start": 27.72, "end": 28.5, "word": " المتوسط", "probability": 0.9942626953125}], "temperature": 1.0}, {"id": 2, "seek": 5512, "start": 29.28, "end": 55.12, "text": "الأنيمية المنجلية كأمراض دم من المواضيع اللي يعني مفهومة بشكل كبير وفيه جوانب معروفة كثير وحالة شائعة بسبب أدى الظروف الاشي اللي كان ناقص من الجداول والـFigures اللي حطيناها الأسبوع المحاضرة اللي فاتت اللي هو الجدول هذا وابعتبره كمان مهم", "tokens": [6027, 33456, 32640, 10632, 9673, 1863, 7435, 1211, 10632, 9122, 10721, 29973, 46958, 11778, 2304, 9154, 9673, 2407, 46958, 40228, 13672, 1829, 37495, 22653, 3714, 5172, 3224, 20498, 3660, 4724, 8592, 28820, 9122, 3555, 13546, 4032, 41185, 3224, 10874, 2407, 7649, 3555, 20449, 32887, 5172, 3660, 9122, 12984, 13546, 4032, 5016, 6027, 3660, 13412, 16373, 27884, 4724, 35457, 3555, 5551, 3215, 7578, 6024, 116, 32887, 5172, 2423, 33599, 1829, 13672, 1829, 25961, 8717, 995, 4587, 9381, 9154, 25724, 28259, 12610, 16070, 39184, 37, 328, 1303, 13672, 1829, 11331, 9566, 1829, 8315, 11296, 16247, 35457, 45367, 9673, 5016, 46958, 25720, 13672, 1829, 6156, 9307, 2655, 13672, 1829, 31439, 25724, 3215, 12610, 23758, 4032, 16758, 34268, 26890, 3224, 9122, 2304, 7649, 3714, 16095], "avg_logprob": -0.15356045216321945, "compression_ratio": 1.8369098712446352, "no_speech_prob": 5.960464477539062e-07, "words": [{"start": 29.28, "end": 30.0, "word": "الأنيمية", "probability": 0.65478515625}, {"start": 30.0, "end": 30.76, "word": " المنجلية", "probability": 0.91796875}, {"start": 30.76, "end": 31.44, "word": " كأمراض", "probability": 0.8048095703125}, {"start": 31.44, "end": 31.8, "word": " دم", "probability": 0.754150390625}, {"start": 31.8, "end": 32.76, "word": " من", "probability": 0.76123046875}, {"start": 32.76, "end": 33.52, "word": " المواضيع", "probability": 0.92919921875}, {"start": 33.52, "end": 34.34, "word": " اللي", "probability": 0.843994140625}, {"start": 34.34, "end": 34.9, "word": " يعني", "probability": 0.92919921875}, {"start": 34.9, "end": 35.54, "word": " مفهومة", "probability": 0.95302734375}, {"start": 35.54, "end": 35.92, "word": " بشكل", "probability": 0.9864908854166666}, {"start": 35.92, "end": 36.54, "word": " كبير", "probability": 0.9959309895833334}, {"start": 36.54, "end": 37.56, "word": " وفيه", "probability": 0.7962239583333334}, {"start": 37.56, "end": 38.06, "word": " جوانب", "probability": 0.9781494140625}, {"start": 38.06, "end": 38.64, "word": " معروفة", "probability": 0.9830322265625}, {"start": 38.64, "end": 39.12, "word": " كثير", "probability": 0.9734700520833334}, {"start": 39.12, "end": 40.72, "word": " وحالة", "probability": 0.979736328125}, {"start": 40.72, "end": 41.3, "word": " شائعة", "probability": 0.9869791666666666}, {"start": 41.3, "end": 42.08, "word": " بسبب", "probability": 0.9957682291666666}, {"start": 42.08, "end": 42.64, "word": " أدى", "probability": 0.6219075520833334}, {"start": 42.64, "end": 43.34, "word": " الظروف", "probability": 0.941650390625}, {"start": 43.34, "end": 44.52, "word": " الاشي", "probability": 0.6980387369791666}, {"start": 44.52, "end": 44.7, "word": " اللي", "probability": 0.907470703125}, {"start": 44.7, 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"probability": 0.99169921875}, {"start": 52.86, "end": 53.56, "word": " الجدول", "probability": 0.9767252604166666}, {"start": 53.56, "end": 53.86, "word": " هذا", "probability": 0.9697265625}, {"start": 53.86, "end": 54.48, "word": " وابعتبره", "probability": 0.793896484375}, {"start": 54.48, "end": 54.84, "word": " كمان", "probability": 0.990234375}, {"start": 54.84, "end": 55.12, "word": " مهم", "probability": 0.986083984375}], "temperature": 1.0}, {"id": 3, "seek": 8627, "start": 57.85, "end": 86.27, "text": "اتفقنا على أنه بالنسبة للـ «هيموغلوبين» فيه عنا أربع فيه عنا أربع copies of the Alpha gene وفيه عنا two copies of the Beta chain gene وبالنسبة للـ «ألفا» في الغالب", "tokens": [9307, 5172, 4587, 8315, 15844, 14739, 3224, 20666, 1863, 35457, 3660, 24976, 39184, 4657, 3224, 32640, 2407, 17082, 1211, 2407, 21292, 1863, 5933, 8978, 3224, 6225, 8315, 5551, 25513, 3615, 8978, 3224, 6225, 8315, 5551, 25513, 3615, 14341, 295, 264, 20588, 12186, 4032, 41185, 3224, 6225, 8315, 732, 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0.6751953125}, {"start": 1088.59, "end": 1088.93, "word": " لا،", "probability": 0.41357421875}, {"start": 1088.93, "end": 1089.57, "word": " هيزوليجر", "probability": 0.6704915364583334}, {"start": 1089.57, "end": 1090.57, "word": " عبارة", "probability": 0.771453857421875}, {"start": 1090.57, "end": 1090.95, "word": " عن", "probability": 0.994140625}, {"start": 1090.95, "end": 1091.19, "word": " الـ", "probability": 0.764404296875}, {"start": 1091.19, "end": 1091.71, "word": " neurological", "probability": 0.64599609375}, {"start": 1091.71, "end": 1092.81, "word": " condition", "probability": 0.9228515625}, {"start": 1092.81, "end": 1094.21, "word": " فيه", "probability": 0.628173828125}, {"start": 1094.21, "end": 1094.33, "word": " الـ", "probability": 0.5213623046875}, {"start": 1094.33, "end": 1094.99, "word": " lysosomal", "probability": 0.82879638671875}, {"start": 1094.99, "end": 1095.61, "word": " disease", "probability": 0.94970703125}, {"start": 1095.61, "end": 1096.89, "word": " نتيجة", "probability": 0.919677734375}, {"start": 1096.89, "end": 1097.89, "word": " الخلل", "probability": 0.9296875}, {"start": 1097.89, "end": 1098.03, "word": " في", "probability": 0.8251953125}, {"start": 1098.03, "end": 1098.19, "word": " الـ", "probability": 0.82666015625}, {"start": 1098.19, "end": 1098.89, "word": " lysosomal", "probability": 0.931396484375}, {"start": 1098.89, "end": 1099.55, "word": " enzymes", "probability": 0.89599609375}, {"start": 1099.55, "end": 1100.37, "word": " الـ", "probability": 0.6474609375}, {"start": 1100.37, "end": 1100.93, "word": " lysosomal", "probability": 0.9368896484375}, {"start": 1100.93, "end": 1101.65, "word": " enzymes", "probability": 0.943359375}, {"start": 1101.65, "end": 1102.55, "word": " عبارة", "probability": 0.9368896484375}, {"start": 1102.55, "end": 1102.79, "word": " عن", "probability": 0.99560546875}, {"start": 1102.79, "end": 1103.77, "word": " الليسوزوم", "probability": 0.8302815755208334}, {"start": 1103.77, "end": 1104.61, "word": " هو", "probability": 0.4326171875}, {"start": 1104.61, "end": 1105.81, "word": " يعني", "probability": 0.8857421875}, {"start": 1105.81, "end": 1106.65, "word": " بالذات", "probability": 0.9666341145833334}, {"start": 1106.65, "end": 1107.23, "word": " للـ", "probability": 0.673095703125}, {"start": 1107.23, "end": 1108.07, "word": " phagocytes", "probability": 0.8179931640625}, {"start": 1108.07, "end": 1108.27, "word": " في", "probability": 0.83984375}, {"start": 1108.27, "end": 1108.97, "word": " المناعة", "probability": 0.9798177083333334}, {"start": 1108.97, "end": 1109.93, "word": " عبارة", "probability": 0.9398193359375}, {"start": 1109.93, "end": 1110.11, "word": " عن", "probability": 0.99267578125}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 1110.680125, "duration_after_vad": 1085.3478437500003}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/ofPBC5zCpyc.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/ofPBC5zCpyc.srt
new file mode 100644
index 0000000000000000000000000000000000000000..343ebb2ce9c0a45316e4a05c44db15e8af82d221
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/ofPBC5zCpyc.srt
@@ -0,0 +1,2758 @@
+1
+00:00:00,000 --> 00:00:03,860
+affected، مش كامل، mild يعني مش صحيح زي اللي بيكون
+
+2
+00:00:03,860 --> 00:00:16,140
+اللي هو homozygous، شوف، يعني المبدأ لموضوع إنه
+
+3
+00:00:16,140 --> 00:00:22,840
+autosomal dominant، ماشي، المبدأ إنه هو اللي بيظهر
+
+4
+00:00:22,840 --> 00:00:31,100
+بس على شرط إن الصفة هذه تعتمد فقط على جين واحد
+
+5
+00:00:31,100 --> 00:00:38,180
+أحيانًا الأمور أعقد من هيك، واللي هو بنبدأ ندخل
+
+6
+00:00:38,180 --> 00:00:42,920
+أكثر في الـ Polygenic اللي كنا نتكلم عنه قبل شوية
+
+7
+00:00:42,920 --> 00:00:47,940
+الأسبوع، مش المحاضرة اللي فاتت، اللي قبلها لما
+
+8
+00:00:47,940 --> 00:00:55,700
+يكون أكثر من جين وEpigenetic Control وكده وهيك، ففي
+
+9
+00:00:55,700 --> 00:01:01,680
+أحيانًا الـ Dominance بيرتبط بـ traits، حكينا مثال
+
+10
+00:01:01,680 --> 00:01:07,560
+الصلع، الصلع في جين معين في الذكور dominant في الـ
+
+11
+00:01:07,560 --> 00:01:11,600
+females recessive، يعني مش دائمًا لما نقول dominant
+
+12
+00:01:11,600 --> 00:01:16,060
+يعني دائمًا dominant وفي كل الحالات dominant وكذا
+
+13
+00:01:16,060 --> 00:01:20,580
+حتى لو إنه على الـ autosomal genes، يعني ما هو مش
+
+14
+00:01:20,580 --> 00:01:24,640
+على الـ sex-linked genes، هدول بس مرتبطة بالجنس
+
+15
+00:01:24,640 --> 00:01:30,920
+فالآن في صفتين إضافيتين على كلمة الـ Dominant بدأت
+
+16
+00:01:30,920 --> 00:01:36,600
+تفهم، إنه أحيانًا Dominance بيسموه مش كامل، يعني
+
+17
+00:01:36,600 --> 00:01:45,280
+صحيح هو موجود بس مش 100%، يعني مش هيظهر في 100% من
+
+18
+00:01:45,280 --> 00:01:51,400
+الناس، أو 100% من الدرجة الشدة، يعني ممكن يكون مثلًا
+
+19
+00:01:51,400 --> 00:01:55,780
+واحد اللي عنده الأليل الـ Dominant، إذا فرضنا صفة
+
+20
+00:01:55,780 --> 00:02:01,670
+معينة، بتلاقيها ظهرت 100%، بينما ممكن والـ
+
+21
+00:02:01,670 --> 00:02:05,990
+heterozygous بتتوقع أنه يكون 50% مثلًا عنده مثلًا
+
+22
+00:02:05,990 --> 00:02:11,630
+نفترض شيء معين، فاللي بتلاقيه في autosomal dominance
+
+23
+00:02:11,630 --> 00:02:18,590
+بتلاقي incomplete penetrance، يعني ما بيظهر بشكل
+
+24
+00:02:18,590 --> 00:02:25,070
+كامل، يعني ممكن ما يظهرش، وفي العكس ممكن يتغير
+
+25
+00:02:25,070 --> 00:02:31,270
+النسب اللي تشوفها، إنه لو autosomal dominance و
+
+26
+00:02:31,270 --> 00:02:38,390
+lethal، يعني مرض شديد جدًا جدًا جدًا بحيث إنه ما في
+
+27
+00:02:38,390 --> 00:02:43,770
+إنسان يولد فيه ويعيش، سواء في فترة الـ embryonic
+
+28
+00:02:43,770 --> 00:02:48,910
+period أو الجنين، أو يعني، فيتغير النسب اللي بتلاقيها
+
+29
+00:02:48,910 --> 00:02:53,180
+فاهم علي كده؟ ففيه Lethal وDominant في بعضها
+
+30
+00:02:53,180 --> 00:02:57,400
+Lethal وبعضها Incomplete Penetrance، والأصل الـ
+
+31
+00:02:57,400 --> 00:03:04,440
+Classical اللي أنت بهيك كمفهوم عام بيقول إنه الـ
+
+32
+00:03:04,440 --> 00:03:10,560
+trait هذه، أو الصفة هذه، بهذا الشكل هي الـ
+
+33
+00:03:10,560 --> 00:03:14,880
+Dominant، فمعناها كذا، فهذا المقصود بمثل هيك أشياء
+
+34
+00:03:14,880 --> 00:03:21,240
+بفرجيكي إياها الآن، بدك ترجع تفهم مرة ثانية شغلة حتى
+
+35
+00:03:21,240 --> 00:03:27,080
+لما اتكلمنا بنرجع لموضوع اللي
+
+36
+00:03:27,080 --> 00:03:35,540
+هو اللي بيسموه الـ Reference Sequence، أنت بتتكلم عن
+
+37
+00:03:35,540 --> 00:03:38,840
+أحيانًا دراسة معينة عملوها في لحظة معينة على
+
+38
+00:03:38,840 --> 00:03:45,740
+مجموعة معينة، على عائلة معينة، كده، ضمن هذه المعطيات
+
+39
+00:03:45,740 --> 00:03:52,250
+اللي هي هذه العائلة، كان الظاهرة
+
+40
+00:03:52,250 --> 00:03:55,970
+الموجودة، واللي بحثناها بهذا الشكل، فبنستنتجها
+
+41
+00:03:55,970 --> 00:04:00,870
+والاستنتاج، فاهم علي كده؟ فأنت كلمة «dominant» لا
+
+42
+00:04:00,870 --> 00:04:06,030
+تعني dominant مطلق، هيك نفس المستوى لكل الجينات وكل
+
+43
+00:04:06,030 --> 00:04:12,330
+العائلات، وكل الناس، لأ، بتلاقي الأمر، إيش اسمه،
+
+44
+00:04:12,330 --> 00:04:19,950
+فيه تفاصيل، في أسئلة أخرى إن شاء الله أجاوب عليها، بس
+
+45
+00:04:19,950 --> 00:04:26,930
+خليني أسأل أسئلة بقى، نعم، أسأل سؤال ثاني بس، أتفضل،
+
+46
+00:04:26,930 --> 00:04:28,190
+أتفضل، أتفضل، أتفضل، أتفضل، أتفضل، أتفضل، أتفضل،
+
+47
+00:04:28,190 --> 00:04:31,090
+أتفضل، أتفضل، أتفضل، أتفضل، أتفضل، أتفضل، أتفضل،
+
+48
+00:04:31,090 --> 00:04:31,110
+أتفضل، أتفضل، أتفضل، أتفضل، أتفضل، أتفضل، أتفضل،
+
+49
+00:04:31,110 --> 00:04:39,150
+أتفضل، أتفضل، أتفضل، أتفضل، أتفضل، أتفضل، أتفضل،
+
+50
+00:04:40,730 --> 00:04:44,670
+وهذا بيكون complete، اللي هو مثلًا نفترض إنه DD
+
+51
+00:04:44,670 --> 00:04:50,610
+كـ capital، والناس الـ males اللي مش maintaining، والـ
+
+52
+00:04:50,610 --> 00:04:56,790
+females برضه، هذه نفترض إنها tigers، لإنه ممكن تكون
+
+53
+00:04:56,790 --> 00:05:00,630
+دي قدرة المسموعة، أنا بتبقى من الـ picture، صحيح؟
+
+54
+00:05:00,630 --> 00:05:05,730
+إيش هو؟ اسمع علي، بس كافي عن الصحيحة
+
+55
+00:05:09,080 --> 00:05:14,240
+الـ "أيه" أنا مش شايفها، شايف اللي حاطط عليها
+
+56
+00:05:14,240 --> 00:05:21,520
+"أيه"، وين 100% بيكون، بس الـ "pedigree" اللي تبع
+
+57
+00:05:21,520 --> 00:05:26,900
+العائلة هذه "أكوندروبلازيا"، "incompletely dominant
+
+58
+00:05:26,900 --> 00:05:31,400
+trait"، بكون لما أنا، شوف أنت عنيه؟ أنا و"جزوف"
+
+59
+00:05:31,400 --> 00:05:36,700
+بتتكلم عنه؟ عن
+
+60
+00:05:36,700 --> 00:05:48,120
+صوت بيه؟ B ما لها؟ ماشي، الـ الـ الآن شو المشكلة هنا
+
+61
+00:05:48,120 --> 00:05:55,180
+المشكلة إنه إذا هذا الـ dominant، واثنين أشخاص
+
+62
+00:05:55,180 --> 00:06:06,600
+عندهم أكوندروبلازيا، ماشي؟ ماشي الحال معايا؟ إذا كان
+
+63
+00:06:09,080 --> 00:06:17,200
+طيب، خلّيني أشارك الشاشة، خلّيني
+
+64
+00:06:17,200 --> 00:06:20,440
+أ... بس عشان لأنهم بيسألوا شو الصورة اللي بنحكي
+
+65
+00:06:20,440 --> 00:06:28,280
+عنها، بحكي عن صورة زي هيك، الـ ... ده ... الأعراض هي عالية
+
+66
+00:06:28,280 --> 00:06:42,480
+ودول اثنين، يعني الـ ... اثنين همّ زوج وزوجة عندهم
+
+67
+00:06:42,480 --> 00:06:47,220
+أكوندروبلازيا، وكنت أنا فحصتهم، ولقيتهم dominant
+
+68
+00:06:47,220 --> 00:06:55,260
+ولقيت two copies، الأصل لو فيه two copies، ماشي؟ يعني
+
+69
+00:06:55,260 --> 00:07:00,260
+لو بقدر واحد يحسبها، لو واحد بس شخص مصاب، الاحتمال
+
+70
+00:07:00,260 --> 00:07:04,660
+المفروض تكون نصف، بس إذا اثنين مصابين لازم تكون أكثر
+
+71
+00:07:04,660 --> 00:07:12,100
+واحتمال واحد منهم كان، يعني يعني، ده اثنين اتزوجوا
+
+72
+00:07:12,100 --> 00:07:21,820
+هيك، ليش الفرد هذا، البنت هذه، طلعت طبيعية؟ ماشي؟ فالآن
+
+73
+00:07:21,820 --> 00:07:29,400
+يعني أنا اللي بتحكيلك إياها عن صور زي هيك، بدك تدخل يعني
+
+74
+00:07:29,400 --> 00:07:34,260
+صعب أكثر، أشرح لك، يعني ده المبدأ، أنت فاهمه من ناحية
+
+75
+00:07:34,850 --> 00:07:37,790
+ماذا يعني Dominant؟ ماذا يعني Recessive؟ ماذا يعني
+
+76
+00:07:37,790 --> 00:07:41,450
+Autosomal؟ وماذا يعني الـ X-linked؟ الـ patterns
+
+77
+00:07:41,450 --> 00:07:45,630
+للـ Inheritance، إذا أنت فاهمها، الآن هنا اثنين
+
+78
+00:07:45,630 --> 00:07:50,430
+مصابين، كيف يطلع لهم ابن طبيعي؟ هذا يجب أن يكون
+
+79
+00:07:50,430 --> 00:07:54,470
+الواحد يتكلم على إنه فيه Incomplete Dominance
+
+80
+00:07:54,470 --> 00:07:58,490
+ماشي، أو Semi-dominant trait، يعني هذا كنوع من
+
+81
+00:07:58,490 --> 00:08:03,830
+التفسير، ممكن إنهم اثنين هم Heterozygous، وهذا طلع
+
+82
+00:08:04,280 --> 00:08:12,820
+من الـ Recessive trait، شو اسمه، اللي هنا Normal
+
+83
+00:08:12,820 --> 00:08:17,740
+طلعت واحدة منهم، يعني اللي هي الربع لما نكون
+
+84
+00:08:17,740 --> 00:08:21,700
+Recessive trait، بس هذه الـ Recessive trait هنا
+
+85
+00:08:21,700 --> 00:08:27,020
+بمعنى إن الـ Disease هو dominant، فالـ Normal هو
+
+86
+00:08:27,020 --> 00:08:32,300
+الـ Recessive، فبيبين شيء، أو إنه يمكن هذا الشخص عنده
+
+87
+00:08:32,300 --> 00:08:36,850
+الـ gene بس مش مبين لأنه مش Completely Dominant
+
+88
+00:08:36,850 --> 00:08:41,370
+Incompletely Dominant يعني، أو Semi-dominant، فاهم
+
+89
+00:08:41,370 --> 00:08:48,290
+عليك كده؟ فالآن يعني ما بتقدر، يعني خد الفكرة من
+
+90
+00:08:48,290 --> 00:08:53,690
+الـ Pedigree، الـ Pedigree، العائلة، هدول عيلتين
+
+91
+00:08:53,690 --> 00:09:01,730
+مختلفتين، صار فيهم mutation في موقع
+
+92
+00:09:01,730 --> 00:09:08,360
+معين، سوّت هذا المرض، شخصين عندهم هذا المرض، اتزوجوا
+
+93
+00:09:08,360 --> 00:09:14,220
+الأصل أنه كل ولادهم، بناتهم، يكونوا يعني مش كلهم، بدل
+
+94
+00:09:14,220 --> 00:09:19,220
+واحد، 75% على الأقل يطلعوا، إذا اثنينهم بيكونوا
+
+95
+00:09:19,220 --> 00:09:29,670
+heterozygous، بيطلعوا affected، وده أنت درست على
+
+96
+00:09:29,670 --> 00:09:36,610
+موضوع، شو اسمه، درست على موضوع المستوى الجيني، بتلاقي
+
+97
+00:09:36,610 --> 00:09:39,970
+أحيانًا ممكن الجين المصاب عند هذا الشخص بيكون شيء
+
+98
+00:09:39,970 --> 00:09:46,730
+مبين عليه، هذه النقطة، صحيح، ماشي نكمل، خليني بس
+
+99
+00:09:46,730 --> 00:09:50,150
+أسأل الـ type عندها ونشوف صح ولا خطأ، إيش هو؟
+
+100
+00:09:50,150 --> 00:09:53,330
+لأني آسفة، تقريبًا سؤالي مش واضح، بدي أكتب الـ genotype و
+
+101
+00:09:53,330 --> 00:09:56,250
+أنت شوف صح ولا خطأ، تقريبًا سؤالي مش واضح، أنا
+
+102
+00:09:56,250 --> 00:10:05,070
+الصورة هنا الـ M، شايفة الـ "أيه" مش شايفة "هل دي
+
+103
+00:10:05,070 --> 00:10:11,270
+كمتل" "هل دي كمتل" "هل
+
+104
+00:10:11,270 --> 00:10:20,390
+دي كمتل" "هل دي كمتل" "هل دي كمتل" "هل دي كمتل"
+
+105
+00:10:20,390 --> 00:10:21,490
+"هل دي كمتل" "هل دي كمتل" "هل دي كمتل" "هل دي
+
+106
+00:10:21,490 --> 00:10:23,150
+كمتل" "هل دي كمتل" "هل دي كمتل" "هل دي كمتل" "هل
+
+107
+00:10:23,150 --> 00:10:24,790
+دي كمتل" "هل دي كمتل" "هل دي كمتل" "هل دي كمتل"
+
+108
+00:10:24,790 --> 00:10:27,370
+"هل دي كمتل" "هل دي كمتل" "هل دي كمتل" "هل دي
+
+109
+00:10:27,370 --> 00:10:29,410
+كمتل" "ه
+
+110
+00:10:32,880 --> 00:10:36,420
+اللي بتوفي هذا، مكتوب في السؤال "dominant
+
+111
+00:10:36,420 --> 00:10:40,940
+-complete"، فمعدل ولادة مباشرة، إنما اللي اللي مش
+
+112
+00:10:40,940 --> 00:10:43,860
+توفي هذا، هذا "incomplete-dominant"، فبقى عايش حتى
+
+113
+00:10:43,860 --> 00:10:48,500
+الآن. بفهم من هيك إن الأم هدول بيكونوا
+
+114
+00:10:48,500 --> 00:10:51,880
+"incomplete-dominant"، والدليل إنه أعطوا بنت سليمة
+
+115
+00:10:51,880 --> 00:10:55,200
+مش مصابة من الأساس، فمتوقع إن هدول بيكونوا مثلًا
+
+116
+00:10:55,200 --> 00:11:00,000
+"Dd"، "Dd"، "welcome to this world" و
+
+117
+00:11:00,000 --> 00:11:03,700
+"this world" و "this world"، منهم اللي هو الصفة
+
+118
+00:11:03,700 --> 00:11:07,860
+المفترضة، صحيح، ما هي اللي كنت حاولتها، صحيح؟ آه،
+
+119
+00:11:07,860 --> 00:11:12,220
+صحيح، أنا بدي أسأل الفكرة هذه، إنه الأب، الميل،
+
+120
+00:11:12,220 --> 00:11:18,680
+والأبوين، بالنسبة لهذا، الأصل تبعهم فوق، مافيش فيه
+
+121
+00:11:18,680 --> 00:11:22,320
+إصابات، يعني هم مافيش إصابة بالمرة، كيف وصلتهم
+
+122
+00:11:22,320 --> 00:11:27,700
+الإصابة، خاصة التوأمين؟ آه، آه، هذه إذا كانت عندهم
+
+123
+00:11:27,700 --> 00:11:31,200
+الصفحة هذه، فطبيعي لازم تكون ظاهرة عند أحد الأبوين
+
+124
+00:11:31,200 --> 00:11:39,320
+فوراً، وبالتالي شو الـ conclusion؟ إن هدول بشر صارت
+
+125
+00:11:39,320 --> 00:11:44,720
+عندهم الـ mutation، هي بدأت in، بضبط، أنا بس الـ
+
+126
+00:11:44,720 --> 00:11:48,520
+mutation طلعت عند الأب والأم مع بعض، صحيح؟
+
+127
+00:11:48,520 --> 00:11:52,740
+إيش هو؟ الـ mutation طلعت عند الأب والأم مع بعض
+
+128
+00:11:52,740 --> 00:11:58,280
+اللي هو الجيل الثاني، آه، آه، آه، هو هنا يعني عيلتين
+
+129
+00:11:58,280 --> 00:12:03,380
+أكوندروبلازيا، بتعرف صورتهم، كيف حجم جسمهم طبيعي، بس
+
+130
+00:12:03,380 --> 00:12:08,220
+أطرافهم قصيرة جدًا، فبيكونوا في الـ Circus، بيكونوا
+
+131
+00:12:08,220 --> 00:12:14,040
+في الأفلام، بتشوفهم أحيانًا كذا، ولا هيك، لو من عيلتين
+
+132
+00:12:14,040 --> 00:12:19,720
+مختلفتين، شخصين بهذه الصفات، حبوا بعض، وتزوجوا بعض
+
+133
+00:12:19,720 --> 00:12:27,320
+بتصير، فاهم علي؟ إلا لما يكونوا زي هيك، نتوقع إنه
+
+134
+00:12:27,320 --> 00:12:34,900
+الـ 75% من الـ من الأطفال
+
+135
+00:12:34,900 --> 00:12:39,860
+اللي بيطلعوا راح يكونوا برضه أكوندروبلازيا، ماشي،
+
+136
+00:12:39,860 --> 00:12:43,280
+واللي
+
+137
+00:12:43,280 --> 00:12:51,980
+عنده 25%، اللي هي الـ 25%، اللي هي الـ double اللي
+
+138
+00:12:51,980 --> 00:12:57,180
+بيكون homozygous، dominant، يمكن يكون lethal، فاهم
+
+139
+00:12:57,180 --> 00:13:05,000
+عليك كيف؟ فبالتالي بيعيش، هذا مفتوح، دكتور، آه، بس في
+
+140
+00:13:05,000 --> 00:13:08,820
+مفتوح ثاني برضه، مش في هذه الصورة، هلجيتها في جزئية
+
+141
+00:13:08,820 --> 00:13:16,480
+الـ X inactivation عند الأنثى؟ نعم، ممكن هو يعمل X
+
+142
+00:13:16,480 --> 00:13:18,900
+inactivation لبعض الجينات، مش كله يعمل X inactivation
+
+143
+00:13:18,900 --> 00:13:25,270
+إيه شو؟ الـ Chromosome X لما يحصل Deactivation عند
+
+144
+00:13:25,270 --> 00:13:28,370
+الأنثى، آه، مش كله بيحصل Deactivation، بيحصل
+
+145
+00:13:28,370 --> 00:13:33,530
+Expression لبعض الجينات، المنسية، لأ، المقصود في الـ
+
+146
+00:13:33,530 --> 00:13:40,550
+Random Deactivation للجينات
+
+147
+00:13:40,550 --> 00:13:45,530
+اللي إحنا بنحكي عنه، الـ Inactivation، بتلاقي الجين
+
+148
+00:13:45,530 --> 00:13:52,540
+كامل مش شغال، مش مفعل، كيف شكله على الميكروسكوب لما
+
+149
+00:13:52,540 --> 00:13:58,520
+تتطلع عليه؟ لما قعدنا نفحص اللي بيكون Barr bodies
+
+150
+00:13:58,520 --> 00:14:05,220
+ماشي، في الـ meiosis والـ mitosis، أو الـ mitosis
+
+151
+00:14:05,220 --> 00:14:12,220
+في الـ meiosis، في الأنثى، بيكون بيسموه فيه شيء
+
+152
+00:14:12,220 --> 00:14:17,340
+بيسموه الـ polar body، هذا بيكون خلية كاملة هي
+
+153
+00:14:17,340 --> 00:14:23,190
+نفسها، بتكون زي النقطة، أما بالنسبة للـ X-Chromosome
+
+154
+00:14:23,190 --> 00:14:29,270
+بتلاقي بشكل عشوائي، مرة هذا ومرة هذا، ما هو ما فيه
+
+155
+00:14:29,270 --> 00:14:35,850
+اثنين في الـ female، واحد بس شغال، والثاني مسكر، فاهم
+
+156
+00:14:35,850 --> 00:14:41,670
+عليك كيف؟ فبنشوفه لما تعمل Barr Body Study، بتشوف
+
+157
+00:14:41,670 --> 00:14:46,260
+النقطة تبع الـ X-Chromosome، وبكون Inactive، كله، مش
+
+158
+00:14:46,260 --> 00:14:49,920
+بعض الجينات شغالة من هذا، وبعض الجينات شغالة من هذا
+
+159
+00:14:49,920 --> 00:14:53,320
+واضح؟
+
+160
+00:14:53,320 --> 00:15:01,960
+طيب، في أسئلة كمان، أنا بقترح اكتبوا الأسئلة
+
+161
+00:15:01,960 --> 00:15:07,540
+وخلينا سواء بأول المحاضرة أو بآخر المحاضرة نحطهم
+
+162
+00:15:07,540 --> 00:15:17,270
+كلهم، وش اسمه؟ ويعني نشوف، ماشي؟ دكتور، في سؤال من
+
+163
+00:15:17,270 --> 00:15:23,030
+دكتور علمًا، قول شو الفرق بين الـ semi-dominant والـ
+
+164
+00:15:23,030 --> 00:15:27,990
+pure-dominant والـ co-dominant، الـ co-dominant
+
+165
+00:15:27,990 --> 00:15:34,990
+لما الـ two traits بتكون زي بعض، رأسًا برأس، اثنين هم
+
+166
+00:15:34,990 --> 00:15:41,950
+بيظهروا، يعني زي الـ ABO system، الـ A والـ B على بعض
+
+167
+00:15:41,950 --> 00:15:47,490
+co-dominant، يعني لو واحد عنده A وB، اثنين بدهم
+
+168
+00:15:47,490 --> 00:15:52,410
+يظهروا تبعهم، فاهم عليك كيف؟ فهذه تسمى Co-
+
+169
+00:15:52,410 --> 00:15:59,910
+dominant، أما الـ A والـ O أو الـ B والـ O، الـ A
+
+170
+00:15:59,910 --> 00:16:04,810
+
+223
+00:21:46,560 --> 00:21:56,540
+مهمة بالنسبة لجزء من الـ يعني احنا الأسهل
+
+224
+00:21:56,540 --> 00:22:01,480
+أحيانًا كتير بنتكلم عن الجين الواحد
+
+225
+00:22:01,480 --> 00:22:07,840
+على إنه هذا من الأب وهذا من الأم على كروموزوم كامل
+
+226
+00:22:07,840 --> 00:22:16,440
+وإن الأمور يعني كل كروموزوم بيظلوا زي ما هو الحقيقة
+
+227
+00:22:16,440 --> 00:22:25,630
+أعقد من هيك بكثير أحيانًا اللي بيصير إنه لو أخذنا
+
+228
+00:22:25,630 --> 00:22:32,710
+الجيل الأجداد، الجيل الأول ذكر وأنثى، تزوجوا،
+
+229
+00:22:32,710 --> 00:22:36,650
+وإذا افترضنا كل واحد منهم كان الكروموزوم تبعه
+
+230
+00:22:36,650 --> 00:22:43,310
+بهذا الشكل ولوّننا على إن هاي الـTwo copies تبعات
+
+231
+00:22:43,310 --> 00:22:50,260
+الجينات تبعات هذا الإنسان في هذا الموقع وعنا كل
+
+232
+00:22:50,260 --> 00:22:56,640
+واحد منها Two copies لما أنا باجي بدرس ترتيب
+
+233
+00:22:56,640 --> 00:23:06,380
+الجينات تبعات الأبناء والبنات، ماشي أحيانًا يعني
+
+234
+00:23:06,380 --> 00:23:14,620
+بعتمد على بالذات إذا الأماكن بعيدة عن بعض، ماشي،
+
+235
+00:23:14,620 --> 00:23:19,500
+في الـDNA بلاقي إنه بتصير ظاهرة بنسميها الـ
+
+236
+00:23:19,500 --> 00:23:27,000
+recombination، الـrecombination إنه بيصير خلال
+
+237
+00:23:27,000 --> 00:23:34,940
+فترات الـcell division بيبدأ تكون بالـgametes
+
+238
+00:23:34,940 --> 00:23:40,520
+يعني بالـova وبالـsperms لما يصير عملية الـ
+
+239
+00:23:40,520 --> 00:23:45,680
+segregation، لما يصير عملية الانفصال
+
+240
+00:23:46,020 --> 00:23:53,160
+الـTwo copies عن بعضها، ماشي؟
+
+241
+00:23:53,160 --> 00:23:56,220
+شو
+
+242
+00:23:56,220 --> 00:24:05,000
+اسمه؟ بالنسبة لـ، لو فرضنا هنا، هاي بدهم يطلعوا على
+
+243
+00:24:05,000 --> 00:24:14,240
+الـDNA بالذات للـX-Chromosome مثلا بالنسبة للإنسان
+
+244
+00:24:14,240 --> 00:24:22,740
+هذابنلاقي إنه صحيح حجم الـDNA كاملاً هيك متساوي
+
+245
+00:24:22,740 --> 00:24:25,920
+ويعني
+
+246
+00:24:25,920 --> 00:24:35,420
+متشابه بس حقيقةً في قطع في كل كروموزوم بيكون من
+
+247
+00:24:35,420 --> 00:24:44,580
+الـ يعني من النسختين اللي قبل، يعني هسة الـhigh
+
+248
+00:24:44,780 --> 00:24:52,520
+الصور الأصلية للكروموزومات تبعات ذكر وأنثى
+
+249
+00:24:52,520 --> 00:25:01,940
+عندما نأخذ البنت الأولى، هذا الكروموزوم أخذته من
+
+250
+00:25:01,940 --> 00:25:10,400
+أبوها، بس صحيح كان في الغالب هذه النسخة من الـ
+
+251
+00:25:10,400 --> 00:25:17,480
+Chromosome، هذا ما هي اللي أخذته؟ بس في البنت بعض
+
+252
+00:25:17,480 --> 00:25:25,780
+القطع من الجينات من النسخة الثانية، ماشي؟ وهي
+
+253
+00:25:25,780 --> 00:25:30,300
+نتيجة أن بين هذه وهذه النسختين، إن شاء الله أنكم
+
+254
+00:25:30,300 --> 00:25:34,200
+بتشوفوا المؤشر اللي بتكلم عنه، صارت عملية
+
+255
+00:25:34,200 --> 00:25:39,430
+Recombination، يطلع لي الكروموزوم من الأب بهذا
+
+256
+00:25:39,430 --> 00:25:44,910
+الشكل، فيه الغالبين العظمى الأصل لهذا الـ
+
+257
+00:25:44,910 --> 00:25:49,790
+Chromosome، بس أخد شوية من القطع من الكروموزوم
+
+258
+00:25:49,790 --> 00:25:56,950
+الثاني، هذه ظاهرة بنسميها Recombination، يعني
+
+259
+00:25:56,950 --> 00:26:05,050
+بالذات إذا الكروموزوم طويل وكان يعني من
+
+260
+00:26:05,050 --> 00:26:09,490
+الكروموزومات الكبيرة مش الصغيرة، بتلاقي إن الظاهرة
+
+261
+00:26:09,490 --> 00:26:15,150
+هذه بتكون نسبتها أعلى، ويكون إنها بتحدث وبتكون إنه
+
+262
+00:26:15,150 --> 00:26:21,850
+ما بنفصل هذولة تماماً عن بعض بشكل مستقل تماماً
+
+263
+00:26:21,850 --> 00:26:29,770
+وإنما، وإنما بيصير عملية Recombination وهي في كل
+
+264
+00:26:30,110 --> 00:26:39,170
+الجينات ولكل الكروموزومات بحيث إنه لما نصل بعد ثالث
+
+265
+00:26:39,170 --> 00:26:48,110
+generation، حقيقة إذا بنلاحظ هنا إنه لما نيجي نربط
+
+266
+00:26:48,110 --> 00:26:56,890
+الكروموزوم تبع الجيل الثالث، الواحد منهم موجود في
+
+267
+00:26:56,890 --> 00:27:06,980
+خواص الأربعة كروموزومات من الأبوين من الجدين في نفس
+
+268
+00:27:06,980 --> 00:27:14,800
+الكروموزوم، فأتأمل أن هذه الخطيئة واضحة أنه عند الـ
+
+269
+00:27:14,800 --> 00:27:21,580
+Cell Division وبالذات في الـGametes عشان يتم
+
+270
+00:27:21,580 --> 00:27:29,750
+نقله يكون هناك اشتراك وعملية ظاهرة الـ
+
+271
+00:27:29,750 --> 00:27:35,010
+Recombination، هي كمان ظاهرة مهمة على مستوى الـ
+
+272
+00:27:35,010 --> 00:27:42,530
+Chromosome بس بتأثر على يعني شو المادة الوراثية
+
+273
+00:27:42,530 --> 00:27:49,590
+اللي بيأخذها أي ابن أو بنت من أبائه وأمهاته
+
+274
+00:27:49,590 --> 00:27:54,010
+وأجداده بالطريقة هذه، فهنا، ظاهرة الـRecombination
+
+275
+00:27:54,770 --> 00:28:00,490
+وهنا يعني الأصل
+
+276
+00:28:00,490 --> 00:28:06,810
+ماشي اللي بيسموه الـIndependent Assortment، إذا
+
+277
+00:28:06,810 --> 00:28:13,890
+كان عندنا يعني حكيت يمكن أنا جملة انتبهت عليها
+
+278
+00:28:13,890 --> 00:28:21,370
+قضية إنه النتائج مندل على الثمان صفات اللي درسها
+
+279
+00:28:22,010 --> 00:28:26,770
+الورد من فوق، لون الحب، خضر أو صفر أو مجعد أو
+
+280
+00:28:26,770 --> 00:28:34,810
+مستديرة، الصفات هذه كانت بالصدفة هيك بالنسبة لكل
+
+281
+00:28:34,810 --> 00:28:42,330
+دراساته أنه كل صفة على كروموزوم مختلف، فالأصل أن كل
+
+282
+00:28:42,330 --> 00:28:53,500
+كروموزوم يعني يتم انفصاله بشكل منفصل تماماً معاه عن
+
+283
+00:28:53,500 --> 00:29:03,180
+الآخر، بس أحيانًا يعني المبدأ اللي أول شيء بنفكر
+
+284
+00:29:03,180 --> 00:29:10,880
+فيه، قضية Independent Assortment، يعني إذا أنا عندي
+
+285
+00:29:10,880 --> 00:29:17,580
+صفة وراثية A capital و small a على locus one على
+
+286
+00:29:17,580 --> 00:29:24,230
+كروموزوم معين، وفيه عندي صفة B على كروموزوم ثاني
+
+287
+00:29:24,230 --> 00:29:32,830
+وبمثلها capital B small b، الأصل بما أن هدولا
+
+288
+00:29:32,830 --> 00:29:40,910
+الصفتين على كروموزومين مختلفين، الأصل أنه لما يصير
+
+289
+00:29:40,910 --> 00:29:53,600
+assortment يعني انفصال بين الكروموزومات، الأصل أنه
+
+290
+00:29:53,600 --> 00:30:05,100
+يعني إذا مثلًا يكون مثلًا عندنا الـIndividual هذا
+
+291
+00:30:05,100 --> 00:30:11,940
+إذا بنشوف كيف هذا أخذ الـCapital A الـG
+
+292
+00:30:11,940 --> 00:30:17,360
+الكروموزوم اللي فيه عنده Capital A وأخذ الـ
+
+293
+00:30:17,360 --> 00:30:27,860
+كروموزوم اللي عنده كابيتل B، ماشي الآن
+
+294
+00:30:27,860 --> 00:30:35,660
+احنا هنا اللي بنحكي عنه في ظاهرة الـMeiosis، يعني
+
+295
+00:30:35,660 --> 00:30:40,440
+عند حدوث الانقسام المنصّف، يعني هدولة الثنتين اللي
+
+296
+00:30:40,440 --> 00:30:48,770
+بنحكي عنهم هنا هم الـOva والـSperm، فالـOva أو
+
+297
+00:30:48,770 --> 00:30:55,310
+الـSperm، هنا الـSperm هذا الحيوان المنوي هذا أخذ
+
+298
+00:30:55,310 --> 00:31:02,110
+الكروموزوم الـCapital A والـCapital B مثلا
+
+299
+00:31:02,110 --> 00:31:07,590
+الاحتمال
+
+300
+00:31:07,590 --> 00:31:13,470
+الثاني أنه هذه المجالات كلها مستحيلة لأن كل واحد
+
+301
+00:31:13,470 --> 00:31:18,730
+عندما يقوم بالانفصال بينهم ليس كل الانفصالات
+
+302
+00:31:18,730 --> 00:31:20,550
+تماماً مثل بعض
+
+303
+00:31:25,050 --> 00:31:30,650
+اللي فيها Capital A أو نسميها من الأب كمصدر أصلي
+
+304
+00:31:30,650 --> 00:31:36,150
+بنتج عنها أنه
+
+305
+00:31:36,150 --> 00:31:42,050
+في الـSperm ثاني، الـA أخد تبع الأب والـB أخد تبع
+
+306
+00:31:42,050 --> 00:31:50,170
+الأم، ماشي؟ فهنا الصورة هذه، ماشي؟ بتبين الأصل في
+
+307
+00:31:50,170 --> 00:31:55,240
+الـIndependent Assortment، يعني الأصل لو الأمور
+
+308
+00:31:55,240 --> 00:32:04,320
+تماماً يعني أخذناها هنا على صفتين وراثيتين على
+
+309
+00:32:04,320 --> 00:32:10,120
+كروموزومين مختلفين، الأصل أنه ما في علاقة بين هذه
+
+310
+00:32:10,120 --> 00:32:17,990
+والثانية، ماشي؟ الأمر ممكن يتعقد أكثر من هيك أنه
+
+311
+00:32:17,990 --> 00:32:24,250
+أحيانًا لما أدرس مثلًا صفتين، واحدة هنا A والافترض
+
+312
+00:32:24,250 --> 00:32:33,810
+بالطرف الثاني C من تحت، الـA والـC مع بعض وSmall A
+
+313
+00:32:33,810 --> 00:32:39,070
+وSmall C مع بعض، هيك الأصل بلاقي أنه مع
+
+314
+00:32:39,070 --> 00:32:42,490
+الـRecombination وقضية الـ
+
+315
+00:32:45,920 --> 00:32:53,540
+الـRecombination هذه كظاهرة ممكن تجعلنا أنه يعني
+
+316
+00:32:53,540 --> 00:32:59,300
+هنا صحيح الجاميتات
+
+317
+00:32:59,300 --> 00:33:03,740
+هنا في Capital A وهنا Capital B وهنا Small A
+
+318
+00:33:03,740 --> 00:33:09,040
+وSmall B بس هذه طلعت Capital A وSmall B وهذه Small
+
+319
+00:33:09,040 --> 00:33:19,330
+A وCapital B، إنه بالأخير ممكن شو اسمه الـ الـ الـ
+
+320
+00:33:19,330 --> 00:33:24,590
+هنا الـcombination أو الـrecombination طلع بشكل
+
+321
+00:33:24,590 --> 00:33:33,450
+مختلف، وبكون هنا شو اسمه؟ بكون هنا بطريقة مختلفة
+
+322
+00:33:33,450 --> 00:33:41,150
+ثانية، ماشي، الـ الـ الـRecombination يعني هي
+
+323
+00:33:41,150 --> 00:33:45,610
+ظاهرة بتحدث بيكون فيها خلال الـCell Division
+
+324
+00:33:45,610 --> 00:33:52,510
+ويروح ويجي وكل مرة بتنقسم الخلايا، اللفة الخيط أو
+
+325
+00:33:52,510 --> 00:33:56,230
+لفة الحبل اللي أنا مطلوب في الكروموزوم أفصله
+
+326
+00:33:56,230 --> 00:34:06,930
+بشكل نظيف وبشكل كامل، بصير إنه بصير تبادل في قطع من
+
+327
+00:34:06,930 --> 00:34:13,550
+الـDNA وبصير عن نتيجة الأمر هذا يعني أنه مش ظاهر
+
+328
+00:34:13,550 --> 00:34:19,970
+أو بيكون Independent Assortment فهي يعني الأصل في
+
+329
+00:34:19,970 --> 00:34:24,970
+الـAssortment أنه يكون كامل، هيك بنفكر بس في
+
+330
+00:34:24,970 --> 00:34:30,130
+الحقيقة بيكون في عندنا اسمها Recombination، الأمر هذا
+
+331
+00:34:30,130 --> 00:34:37,940
+مربوط أو مهم في قضايا إنه لما يكون عندي أكثر من صفة
+
+332
+00:34:37,940 --> 00:34:43,980
+مشتركة مع بعض، يعني مثلًا اللي هي بيسموها Linked
+
+333
+00:34:43,980 --> 00:34:49,020
+disequilibrium وراح نتكلم عنها بعدين، اللي هي إنه
+
+334
+00:34:49,020 --> 00:34:55,100
+إذا الصفة Capital A بتيجي معاها إشي معين، ظاهرة
+
+335
+00:34:55,100 --> 00:35:01,580
+الـRecombination بتكون مؤثرة وأوضح لما تكون القطع
+
+336
+00:35:01,580 --> 00:35:08,090
+من الـDNA، القطع أو الجينات على الكروموزوم بعيدة عن
+
+337
+00:35:08,090 --> 00:35:15,130
+بعض، وفي طول في الكروموزوم، فإنه يكون قصير والجينات
+
+338
+00:35:15,130 --> 00:35:19,250
+جانب بعض، في الغالب بتتركب مع بعض وبتظلها مع بعض
+
+339
+00:35:19,250 --> 00:35:30,050
+فهنا الـCrossing over بتلاقي يعني ممكن واحد
+
+340
+00:35:30,050 --> 00:35:38,470
+يدرسها، خلينا من، يعني هذه النقاط تفاصيلها بالنسبة
+
+341
+00:35:38,470 --> 00:35:46,710
+لـ يعني الـ بالنسبة لتفاصيلها بدنا إياها كتير يعني
+
+342
+00:35:46,710 --> 00:35:49,750
+الـ
+
+343
+00:35:49,750 --> 00:35:54,450
+إذا افترضنا إن الـ
+
+344
+00:35:58,430 --> 00:36:04,470
+لما يكون فيه عندي أكثر من قليل A وB بالنسبة
+
+345
+00:36:04,470 --> 00:36:11,250
+للمشاكل اللي حصلت عندنا، الـCrossing over، ماشي، إذا
+
+346
+00:36:11,250 --> 00:36:16,170
+افترضنا إنه بالصدفة هنا Capital A وCapital B وهنا
+
+347
+00:36:16,170 --> 00:36:21,250
+Small a وSmall b، لما يصير عندي هيك الأصليات أو
+
+348
+00:36:21,250 --> 00:36:27,010
+هيك، أنا لقيت إشي معين، فيه مرات بلاقي إن الـ
+
+349
+00:36:27,010 --> 00:36:32,100
+Product سيكون Small a مع Capital B أو Capital A مع
+
+350
+00:36:32,100 --> 00:36:42,260
+Small b، ممكن تكون موجودة يعني، ماشي يعني يمكن لو
+
+351
+00:36:42,260 --> 00:36:47,360
+يعني
+
+352
+00:36:47,360 --> 00:36:56,700
+ممكن أحيانًا أكثر ظاهرة يعني أنا يعني بفكر فيها
+
+353
+00:36:58,000 --> 00:37:04,580
+بتحدث فيه هذه الشغلة بالنسبة مثلا لـHLA Antigen
+
+354
+00:37:04,580 --> 00:37:09,320
+اللي هم تبعات المناعة، اللي هو الـMHC Molecules
+
+355
+00:37:09,320 --> 00:37:13,940
+في عندنا الـMHC Molecules أو الـHLA Antigens
+
+356
+00:37:13,940 --> 00:37:20,940
+الـClass I والـClass II ويكون، يعني حتى لقينا
+
+357
+00:37:20,940 --> 00:37:26,260
+أنه لما نيجي نفحص الـHLA Class I نفحص الـA والـ
+
+358
+00:37:26,260 --> 00:37:33,100
+B وما نفحصش الـC، السبب أنه لقوا أن الـB بيمشي
+
+359
+00:37:33,100 --> 00:37:38,640
+معاه C معين، فبحيث أنه يعني في الغالب أن الواحد
+
+360
+00:37:38,640 --> 00:37:44,800
+يدرس ويتغلب أنه يدرس الـHLA C مافيش داعي له يعني
+
+361
+00:37:44,800 --> 00:37:51,950
+سريرياً وعلمياً في حالات معينة بسبب ظاهرة نسميها
+
+362
+00:37:51,950 --> 00:37:57,190
+linkage disequilibrium، إنه إذا عندي Capital A
+
+363
+00:37:57,190 --> 00:38:03,610
+معين بيكون عندي الـB Capital كمان، وإذا الـB الـ
+
+364
+00:38:03,610 --> 00:38:09,130
+A صغير بلاقي الأليل اللي معاه الـB صغير مثلا،
+
+365
+00:38:09,130 --> 00:38:14,110
+نفترض ذلك، فهذه يعني قضايا
+
+366
+00:38:14,950 --> 00:38:23,230
+أحيانًا زي ظاهرة الـlinkage disequilibrium بتكون
+
+367
+00:38:23,230 --> 00:38:32,210
+نتيجتها إنه يعني راح تكون راح
+
+368
+00:38:32,210 --> 00:38:39,750
+تكون نتيجتها إنه يعني في مجال إنه يتغيروا بحيث إنه
+
+369
+00:38:39,750 --> 00:38:44,310
+كل ما كانوا الجينات
+
+370
+00:38:44,600 --> 00:38:50,900
+مواقعهم قريبة مع بعض راح يكونوا بيمشوا مع بعض، وكل
+
+371
+00:38:50,900 --> 00:38:54,880
+ما كانوا مجال إنه يكونوا بعاد عن بعض راح تكون
+
+372
+00:38:54,880 --> 00:38:58,480
+الاحتمالية
+
+373
+00:38:58,480 --> 00:39:02,720
+الـRecombination، ويكون إنه فيه اختلافات أكبر
+
+374
+00:39:02,720 --> 00:39:09,880
+بكثير، ماشي؟ هنا حاطين يعني تقييم للي حكينا
+
+375
+00:39:09,880 --> 00:39:15,530
+الـstrong linkage disequilibrium، والمثال اللي حطيه
+
+376
+00:39:15,530 --> 00:39:21,290
+لكم إياه، retinitis pigmentosa، نفس الـ
+
+377
+00:39:21,290 --> 00:39:26,930
+جين المسؤول عنه، شكله فيه صعوبة أننا نفحصه أو
+
+378
+00:39:26,930 --> 00:39:31,990
+احنا مش فاهمين شو دوره وشو هو ولا كده، بس اللي
+
+379
+00:39:31,990 --> 00:39:39,270
+بيصير أنه ندرس عن طريق اللي هو بيسموه marker
+
+380
+00:39:39,270 --> 00:39:46,180
+locus 2، يعني أنه
+
+381
+00:39:46,180 --> 00:39:52,380
+أحيانًا يعني إذا تخيلنا هنا الـretinitis
+
+382
+00:39:52,380 --> 00:39:59,780
+pigmentosa، الجين اللي هو الـD هذا، فهذا الإنسان
+
+383
+00:39:59,780 --> 00:40:04,940
+هنا هي Female مصابة وعندها الـD Capital لأنه شكله
+
+384
+00:40:04,940 --> 00:40:11,490
+متزامل dominant، ماشي؟ والجين الثاني أو النسخة
+
+385
+00:40:11,490 --> 00:40:16,470
+الثانية طبيعية اللي هي Normal Small Capital، تزوجت
+
+386
+00:40:16,470 --> 00:40:23,690
+شخص طبيعي، فالآن هاي
+
+387
+00:40:23,690 --> 00:40:29,810
+الـجين اللي هو مسبب للمرض، ماشي أنا فيه صعوبة أني
+
+388
+00:40:29,810 --> 00:40:37,170
+أدرسه فيه لسبب ما، مشكلة أني أبحث عليه، فإذا
+
+389
+00:40:37,170 --> 00:40:37,790
+لقيت
+
+390
+00:40:40,530 --> 00:40:49,250
+Two markers يعني جينات ثانية أنا وجدت المكافئة لها
+
+391
+00:40:49,250 --> 00:40:53,650
+بحيث أني بقدر أعلم عليها، بقدر أعمل زي ما حكينا
+
+392
+00:40:53,650 --> 00:40:58,050
+fluorescence immunofluorescence
+
+393
+00:40:58,050 --> 00:41:02,730
+in-cyto-hybridization اللي هي الـFISH مثلا، على إنه
+
+394
+00:41:02,730 --> 00:41:06,950
+علاقة موجودة أو لا مش موجودة، النسخة اللي أنا بدي
+
+395
+00:41:06,950 --> 00:41:16,990
+إياها، فالفكرة أنه في حالة هذا الجين المسبب للمرض
+
+396
+00:41:16,990 --> 00:41:24,070
+هنا، إذا عندي Two Markers بحب أستخدمهم، الأحسن ليه
+
+397
+00:41:24,070 --> 00:41:30,170
+أنه أستخدم الـMarker اللي هو الـB لأن هذا قريب
+
+398
+00:41:30,170 --> 00:41:36,380
+
+445
+00:46:41,490 --> 00:46:48,590
+يعني انتقالها من شخص لشخص وكيف بيكون مجموعة الصفات
+
+446
+00:46:48,590 --> 00:46:55,050
+بتيجي مع بعض وهي أحيانًا يعني من الظواهر اللي إحنا
+
+447
+00:46:55,050 --> 00:47:01,190
+بنحكي عنها مرات اللي هي أنه Polygenetic Disorders
+
+448
+00:47:01,190 --> 00:47:09,690
+أو Conditions أكثر بكثير بتكون أنه الـ … بتكون أنه
+
+449
+00:47:09,690 --> 00:47:16,090
+الـ Recombination حدث أو ممكن يحدث، بس كل ما كانوا
+
+450
+00:47:16,090 --> 00:47:20,150
+القطعتين بعيد عن بعض، بيصير الـ Recombination أكثر
+
+451
+00:47:20,150 --> 00:47:25,570
+كل ما كانوا قريبات على بعض، بيكون الإمكانية إنه
+
+452
+00:47:25,570 --> 00:47:30,630
+يمشوا اثنين مع بعض أكثر، فهذه يعني ظاهرة بتحدث،
+
+453
+00:47:30,630 --> 00:47:35,270
+ظاهرة يعني أحيانًا بتكون مهم إن الواحد يتذكرها
+
+454
+00:47:35,270 --> 00:47:42,200
+و يعني أحيانًا بتكون لها أهمية سريرية من ناحية كيف
+
+455
+00:47:42,200 --> 00:47:50,360
+نتعامل مع الموضوع هذا، فيه أسئلة نفس
+
+456
+00:47:50,360 --> 00:47:57,660
+الفكرة، كل ما أبعدوا الجينات عن بعض على الـ DNA، على
+
+457
+00:47:57,660 --> 00:48:02,140
+الـ Chromosome، احتمال إن يكونوا الـ Alleles
+
+458
+00:48:02,140 --> 00:48:07,720
+مختلفين عن بعض، بتكون النسبة أكبر، فتفاصيل الأمور
+
+459
+00:48:07,720 --> 00:48:16,650
+بتديشيها يعني too much details، ماشي، الـ load score
+
+460
+00:48:16,650 --> 00:48:23,790
+اللي هو logarithmic، نسيت اختصار يعني اللي هو معامل
+
+461
+00:48:23,790 --> 00:48:27,270
+احتمالية
+
+462
+00:48:27,270 --> 00:48:36,710
+انتقال الأليل مع بعض، ماشي، فهنا
+
+463
+00:48:36,710 --> 00:48:37,750
+three families
+
+464
+00:48:40,600 --> 00:48:48,580
+شو اسمه؟ تفاصيلها خلاص، بلا منها، ماشي، تسألونيش
+
+465
+00:48:48,580 --> 00:48:55,500
+يعني بالنسبة له، بدنا ندخل بتفاصيل هنا، يعني الـ
+
+466
+00:48:55,500 --> 00:49:00,980
+«take home message»، الرسالة اللي بدنا إياها إنه
+
+467
+00:49:00,980 --> 00:49:09,310
+رياضياً أنا ممكن أعبر عن ارتباط أليل معين بأليل
+
+468
+00:49:09,310 --> 00:49:13,110
+آخر، والقصد في الموضوع اللي هي الظاهرة اللي هنا
+
+469
+00:49:13,110 --> 00:49:21,650
+اللي هي أنه أنا ببدأ يعني بالـ Chromosomes
+
+470
+00:49:21,650 --> 00:49:28,190
+وعليها الأليل في الـ Locus مثلاً A1 بشكل معين
+
+471
+00:49:28,190 --> 00:49:36,770
+و Chromosome ثاني بكون بشكل آخر، الـ Locus 2 وفيه
+
+472
+00:49:36,770 --> 00:49:43,040
+Capital B و Small b، بالأخير اللي موجود بعد مرور كذا
+
+473
+00:49:43,040 --> 00:49:49,080
+generation، وبسبب الـ Recombination الأمور راح تكون
+
+474
+00:49:49,080 --> 00:49:54,960
+أنه أي قطعة بتكون الأصول من كل الأصول بتلاقيها
+
+475
+00:49:54,960 --> 00:50:01,120
+موجودة، يعني اللي هي كمان هنا اللي هي أنه بيصير هذا
+
+476
+00:50:01,120 --> 00:50:06,220
+الإنسان الـ third generation، الـ Chromosome الأول،
+
+477
+00:50:06,220 --> 00:50:09,840
+مع أنه بالأول الواحد هيك بيحب أنه يفكر أنه الـ DNA
+
+478
+00:50:09,840 --> 00:50:18,880
+والـ Cell Division هيك يعني نظيف وكامل وبينفصل
+
+479
+00:50:18,880 --> 00:50:23,620
+بشكل تام، إلا أنه الأمور أعقد من هيك وأنه بتصير
+
+480
+00:50:23,620 --> 00:50:28,180
+عملية الـ Recombination ونتيجتها اللي هي Linked
+
+481
+00:50:28,180 --> 00:50:35,820
+Disequilibrium، يعني أنه الـ Loci أو المكان على الـ
+
+482
+00:50:35,820 --> 00:50:42,920
+DNA إذا كان قريب من بعض، هنا في الغالب هيمشوا مع
+
+483
+00:50:42,920 --> 00:50:51,640
+بعض، بينما لما يكونوا بعيد، راح يصير الاختلاف إن هنا
+
+484
+00:50:51,640 --> 00:50:58,040
+مثلاً هاي Capital A، small a في الـ Locus 1
+
+485
+00:50:58,040 --> 00:51:05,880
+وهنا Capital B، small b في الـ Locus 2، النتيجة إذا
+
+486
+00:51:05,880 --> 00:51:13,920
+صار عندي عملية الـ Recombination، ماشي، هنا هذه
+
+487
+00:51:13,920 --> 00:51:21,540
+النسخة شبيهة بالأصلي، بينما هذه جلبت، فصار الـ
+
+488
+00:51:21,540 --> 00:51:26,820
+Capital A مع small b، والـ small a مع الـ Capital
+
+489
+00:51:26,820 --> 00:51:32,480
+B، تصير عملية الـ Recombination، ماشي، تفاصيلها كيف كل
+
+490
+00:51:32,480 --> 00:51:39,260
+واحدة يعني شلون
+
+491
+00:51:39,260 --> 00:51:41,420
+الـ non-recombinant والـ recombinant والـ
+
+492
+00:51:41,420 --> 00:51:46,220
+recombinant، هدول اثنتين زي بعض، بس المهم أنه جلبت
+
+493
+00:51:46,220 --> 00:51:51,340
+صارت عملية recombination هنا، ماشي، بس إذا كانوا
+
+494
+00:51:51,340 --> 00:51:56,810
+قريبين على بعض، لا يوجد تجانس مرتبط، بيبقى كما
+
+495
+00:51:56,810 --> 00:52:03,410
+هو، بيبقى … يعني عندما ندرس باستخدام الـ two loci
+
+496
+00:52:03,410 --> 00:52:08,650
+هذول، بما أنهم قريبين على بعض، احتمالية أنه يمشوا
+
+497
+00:52:08,650 --> 00:52:14,390
+مع بعض أكبر بكثير، كل ما أبعدوا بيصير فيه احتمالية
+
+498
+00:52:14,390 --> 00:52:19,330
+أكبر أنه يصير عملية الـ recombination، ماشي
+
+499
+00:52:21,210 --> 00:52:31,150
+يعني هنا حاطين أنه أحيانًا القطع واللصق بالنسبة للـ
+
+500
+00:52:31,150 --> 00:52:38,610
+Recombination بنتج عنه أنه الكمية
+
+501
+00:52:38,610 --> 00:52:44,170
+أكبر، يعني عدد الخلايا اللي فيها هذول الاثنين معاً
+
+502
+00:52:44,170 --> 00:52:44,710
+مع بعض
+
+503
+00:52:47,490 --> 00:52:52,630
+يعني إن الجينين هذول ماشوا مع بعض أكثر، مش في
+
+504
+00:52:52,630 --> 00:52:57,690
+مثلاً كل الخلايا، أو نصف الخلايا، أو كذا، يعني إن شاء
+
+505
+00:52:57,690 --> 00:53:04,210
+الله هذه الفكرة تكون واضحة، وتأثيراتها في قضية إنه
+
+506
+00:53:04,210 --> 00:53:10,570
+أحيانًا أنا ما عندي الـ الـ الـ الـ issue محدد للـ
+
+507
+00:53:10,570 --> 00:53:17,150
+gene causing disease، بكون عندي شيء قريب منه
+
+508
+00:53:17,150 --> 00:53:21,350
+فإذا عندي الشيء القريب منه، بهمني إنه يكون هذا
+
+509
+00:53:21,350 --> 00:53:26,030
+الشيء قريب جداً، على طول ملزق فيه، لأنه إذا كان على
+
+510
+00:53:26,030 --> 00:53:29,530
+طول ملزق فيه، احتمالية إنه يكون بينهم Recombination
+
+511
+00:53:29,530 --> 00:53:37,610
+قليلة، كل ما أبعد بيكون الأمور أصعب، في أسئلة؟
+
+512
+00:53:43,700 --> 00:53:47,560
+كاريم بده يتكلم يا دكتور، مش عارف يبدو عنده سؤال
+
+513
+00:53:47,560 --> 00:53:54,940
+نعم، فضل، حقيقة أنت كنت في سنة، وصار هناك
+
+514
+00:53:54,940 --> 00:53:59,280
+combination بين الجينات، تصبح فرصة أصعب إنه يمشوا
+
+515
+00:53:59,280 --> 00:54:07,720
+الجينات مع بعض، وينتقلوا مع بعض؟ لما أنا أتكلم على،
+
+516
+00:54:07,720 --> 00:54:14,150
+أساساً أنا بتكلم على two loci، يعني مكانين على
+
+517
+00:54:14,150 --> 00:54:21,370
+الـ يعني مثلاً أنا بتكلم خاصية الـ ABO group مثلاً
+
+518
+00:54:21,370 --> 00:54:32,830
+مع الـ Rh group، ماشي، لفصيلة الدم، بس إذا الـ ABO
+
+519
+00:54:32,830 --> 00:54:40,290
+Locus قريب من Locus، يعني محل ما هذا الـ gene موجود
+
+520
+00:54:40,290 --> 00:54:46,570
+الـ Rh قريب كثير، شو راح يصير؟ بيصير ما في داعي
+
+521
+00:54:46,570 --> 00:54:51,570
+تفحص الـ RH، فاهم عليّ أيه؟ أو تفحص الـ ABO
+
+522
+00:54:51,570 --> 00:54:57,950
+بيكفيني واحد، لأنه الثاني بلزق فيه، جاي معاه، يعني كل
+
+523
+00:54:57,950 --> 00:55:04,730
+ما كانوا أبعد، ماشي الـ … كل ما كانوا أبعد، احتمالية
+
+524
+00:55:04,730 --> 00:55:09,350
+أن يصير الـ recombination أكبر، يعني لو جيت في
+
+525
+00:55:09,350 --> 00:55:15,320
+generation معينة، أنا عائلة معينة درست عليها الـ ABO
+
+526
+00:55:15,320 --> 00:55:20,700
+و الـ Rh، ورحت دورت وين ما كان الـ «جين» هذا، ماشي
+
+527
+00:55:20,700 --> 00:55:26,480
+إذا قريبات كثير على بعض، راح ألاقي إنه فيه ارتباط، و
+
+528
+00:55:26,480 --> 00:55:34,480
+إنه بيصير هو يعني الـ «ماركر» اللي هو عندي
+
+529
+00:55:34,480 --> 00:55:41,100
+أستخدمه كمان عشان أدرس هذه الظاهرة، بيكون مفيد كثير
+
+530
+00:55:41,100 --> 00:55:47,740
+لأنه قريب كثير، وما في Recombination، وبنسميه فيه
+
+531
+00:55:47,740 --> 00:55:50,840
+Linked Disequilibrium، هذه الكلمة اللي بدي إياها
+
+532
+00:55:50,840 --> 00:55:57,880
+اللي هي إنه في عندنا ارتباط بين الـ الـ الـ الـ
+
+533
+00:55:57,880 --> 00:56:03,380
+إذا الأليل هذا A Capital بيجي معاه مثلاً الـ B
+
+534
+00:56:03,380 --> 00:56:07,380
+Capital، أو بيجي معاه شيء محدد، فأنا هيبقى أستفيد من
+
+535
+00:56:07,380 --> 00:56:09,440
+هذه الظاهرة، ماشي؟
+
+536
+00:56:14,880 --> 00:56:22,520
+يعني استخدام هذا المفهوم، بيكون أحيانًا سريرياً، ليش
+
+537
+00:56:22,520 --> 00:56:29,940
+ندرس بشكل معين، وأحيانًا أنه أنا ممكن تجيني حالة
+
+538
+00:56:29,940 --> 00:56:39,640
+عندها مرض، ما يكون عندها الـ Marker الـ Exact للجين
+
+539
+00:56:39,640 --> 00:56:47,190
+المسبب للمرض، فمضطر أنا أستخدم Marker لجين شيء قريب
+
+540
+00:56:47,190 --> 00:56:55,890
+منه، إذا الشيء القريب منه هذا اللي استخدمته، يعني ما
+
+541
+00:56:55,890 --> 00:56:59,550
+هي الفكرة، أنه لما يكون عند عائلة عندها الحالة، يعني
+
+542
+00:56:59,550 --> 00:57:03,730
+زي مثلاً ما اتكلمنا على إن نفرض الـ Retinitis
+
+543
+00:57:03,730 --> 00:57:10,870
+Pigmentosa بهذا الشكل، ماشي، أب وأم، الأم مصابة، جابوا
+
+544
+00:57:10,870 --> 00:57:17,500
+ثمان أفراد، ثلاثة مصابين، وخمسة مش مصابين، هذه الحالة
+
+545
+00:57:17,500 --> 00:57:23,340
+المثالية اللي أنا بروح بدرسها، ولما ألاقي عائلة زي هيك أنا
+
+546
+00:57:23,340 --> 00:57:28,240
+لما فرجتكم، شوفتم، تذكروا صورة اليد اللي إيديهم
+
+547
+00:57:28,240 --> 00:57:32,000
+عندهم، قلنا سميناه أقرب شيء له زي الـ Infantile
+
+548
+00:57:32,000 --> 00:57:35,980
+Digital Fibromatosis، اللي هي صورة الإصابة بشكل
+
+549
+00:57:35,980 --> 00:57:42,780
+معين، فلما تجيني عائلة زي هيك، أنا في عندي إشكالية إنه
+
+550
+00:57:42,780 --> 00:57:49,100
+أنا ما بعرف مية بالمية الـ Gene والـ Locus اللي هو
+
+551
+00:57:49,100 --> 00:57:56,910
+مسبب للمرض، أنا ما بعرفه، بس ممكن أستفيد إذا فيه شيء
+
+552
+00:57:56,910 --> 00:58:01,650
+قريب جداً عليه، كأنه أستخدمه كـ Marker، بعدين مثلاً
+
+553
+00:58:01,650 --> 00:58:11,950
+خلفه جابه شخص، يعني صارت يعني المرأة هذه حملت، جابت
+
+554
+00:58:11,950 --> 00:58:16,430
+التاسع، يسألوا هذا بدي يطلع مصاب ولا مش مصاب مثلاً
+
+555
+00:58:16,430 --> 00:58:21,290
+بدك تدرس وتستفيد من ظاهرة الـ linkage
+
+556
+00:58:21,290 --> 00:58:25,590
+disequilibrium، تكون متأكد، الـ Marker اللي أنا
+
+557
+00:58:25,590 --> 00:58:31,550
+هستخدمه، أنا مش متأكد إنه للـ Disease 100%، إنما أنا
+
+558
+00:58:31,550 --> 00:58:34,610
+بتوقع إنه هو، عشان قريب من الـ Disease، بقدر أستفيد
+
+559
+00:58:34,610 --> 00:58:44,950
+منه، ضمن الدراسة، فالـ في الحالة هذه، بنستخدم
+
+560
+00:58:44,950 --> 00:58:53,070
+الـ Marker، وبكون يعني، ببدأ أكون منتبه إنه الـ Marker
+
+561
+00:58:53,070 --> 00:59:00,990
+اللي لقيته، قد إيش دقيق في أنه يكون قريب من الـ
+
+562
+00:59:00,990 --> 00:59:06,690
+Disease Gene، حيث أنه يكون، إذا Marker كويس، بيكون
+
+563
+00:59:06,690 --> 00:59:13,050
+الـ Load تبعه، ماشي، اللي هو المعامل الارتباط تبعه
+
+564
+00:59:13,050 --> 00:59:16,030
+Code-Theoretic، فهذه النقطة اللي بدنا إياها
+
+565
+00:59:19,460 --> 00:59:23,900
+دكتور، في سؤال من Carmel، بتقول إيش الفرق ما بين الـ
+
+566
+00:59:23,900 --> 00:59:29,740
+recombination والـ crossing over؟ هما نفسهم، هما نفسهم،
+
+567
+00:59:29,740 --> 00:59:38,860
+الـ crossing over يعني عملية حدوث انتقال من الـ DNA
+
+568
+00:59:38,860 --> 00:59:47,380
+كقطعة من جهة إلى جهة أخرى، ماشي، نتيجة الأمر هذا
+
+569
+00:59:47,380 --> 00:59:55,940
+أنه هيصير عندي recombination، إنه يعني هو نتيجة
+
+570
+00:59:55,940 --> 01:00:05,100
+نتيجة الحدث هذا، يعني المتشابهات، يعني ماشي، الـ
+
+571
+01:00:05,100 --> 01:00:11,480
+crossing over هي الظاهرة اللي بتسبب لي القضية
+
+572
+01:00:11,480 --> 01:00:14,820
+بتسبب لي
+
+573
+01:00:14,820 --> 01:00:23,420
+قضية الـ recombination، ماشي، الـ يعني تتذكروا لما
+
+574
+01:00:23,420 --> 01:00:28,500
+حكينا مثلاً حتى عن زي الـ Down Syndrome، الـ
+
+575
+01:00:28,500 --> 01:00:37,100
+Crossing Over، ماشي، بقطع ولصق في الـ DNA من قطع مش
+
+576
+01:00:37,100 --> 01:00:45,980
+المفروض تكون مع بعض، ماشي؟ فالقطع واللصق أحياناً
+
+577
+01:00:47,660 --> 01:00:53,660
+بيكون غير متساوي، أو القطع واللصق راح ينتج عنه إنه فيه
+
+578
+01:00:53,660 --> 01:00:58,660
+قطعة كبيرة زيادة، وفيه قطعة صغيرة، فهنا شو صار عندي؟
+
+579
+01:00:58,660 --> 01:01:04,580
+هنا صار عندي Crossing Over، بس الـ Recombination هي
+
+580
+01:01:04,580 --> 01:01:08,980
+المحصلة النهائية، لما يكونوا Balanced، لما يكونوا
+
+581
+01:01:08,980 --> 01:01:16,080
+متوازنين، لما تكون يعني بالأخير يقدر ينتج الصفات
+
+582
+01:01:16,080 --> 01:01:21,740
+الوراثية، ويولد جنين، ويولد طفل، ويولد يوجد إنسان
+
+583
+01:01:21,740 --> 01:01:27,800
+جديد، فالـ Recombination يعني آليتها الـ Crossing
+
+584
+01:01:27,800 --> 01:01:34,460
+Over، بس الـ Crossing Over ممكن يسبب مشاكل غير الـ
+
+585
+01:01:34,460 --> 01:01:40,840
+Recombination، أو يعني ظواهر أشد وغير، يعني أسأل،
+
+586
+01:01:40,840 --> 01:01:45,720
+يعني أتمنى يكون الأمر واضح، أيوة كريم، إذا عنده
+
+587
+01:01:45,720 --> 01:01:57,080
+سؤال، بالنسبة
+
+588
+01:01:57,080 --> 01:02:09,500
+لما ندرس ظواهر زي هيك، يعني حقيقة من الأشياء
+
+589
+01:02:09,830 --> 01:02:17,770
+اللي عم بيستفيدوا منها، هي قضية الـ Genome-wide
+
+590
+01:02:17,770 --> 01:02:27,570
+Association Study، الـ GWAS، لما
+
+591
+01:02:27,570 --> 01:02:30,910
+نكون
+
+592
+01:02:30,910 --> 01:02:37,910
+عندنا إمكانية نعمل Sequencing لكل الـ DNA، لكل 3
+
+593
+01:02:37,910 --> 01:02:45,100
+مليارات نيوكليوتايد، مرة واحدة، وأجي أنا أعملهم، ماشي
+
+594
+01:02:45,100 --> 01:02:56,020
+لما يكون شيء زي هيك، بإمكاني
+
+595
+01:02:56,020 --> 01:03:06,570
+معاه أدرس، وأكون يعني، محدد إذا كان عندي Markers
+
+596
+01:03:06,570 --> 01:03:15,050
+كويسة لبعض الـ Diseases، بسير أشوف احتمالية حدوث
+
+597
+01:03:15,050 --> 01:03:22,750
+أمراض معينة، وهذه عادة، يعني هذه عبارة عن خدمة
+
+598
+01:03:22,750 --> 01:03:27,870
+متوفرة في الدول المتقدمة، يعني مثلاً في أمريكا
+
+599
+01:03:27,870 --> 01:03:32,510
+بتعطيهم عينة دم تبعك، ماشي
+
+600
+01:03:35,540 --> 01:03:41,320
+اللي بيعملوا genome-wide association study، اللي
+
+601
+01:03:41,320 --> 01:03:46,200
+اسمه الـ GWAS، النتيجة بتاعتها بيسموها «Manhattan
+
+602
+01:03:46,200 --> 01:03:54,300
+Plot»، بياخذ الشكل، الفكرة أنه يعني
+
+603
+01:03:54,300 --> 01:04:01,530
+نتيجة تبع الأمر هذا، أنه سواء عندي الـ Marker للـ
+
+604
+01:04:01,530 --> 01:04:06,930
+Gene نفسه، المسبب للمرض، والطبيعي، وبقدر أفرق بينهم، أو
+
+605
+01:04:06,930 --> 01:04:14,530
+Marker لشيء قريب منه، بحيث أنه يكون في ارتباط مع
+
+606
+01:04:14,530 --> 01:04:24,930
+الـ Disease معينة، بقدر أعطي الإنسان تقرير بحيث أنه
+
+607
+01:04:24,930 --> 01:04:34,160
+يعني إذا الواحد بيشوف الأشياء اللي موجودة، ماشي
+
+608
+01:04:34,160 --> 01:04:41,340
+مثلاً CFTR اللي هو Cystic Fibrosis Inheritance
+
+609
+01:04:41,340 --> 01:04:50,840
+مثلاً ADAMTS13 تبع مثلاً الـ TTP اللي هو
+
+610
+01:04:50,840 --> 01:04:56,140
+«Thrombotic Thrombocytopenic Purpura»، مش عارف كده
+
+611
+01:04:56,660 --> 01:05:04,900
+فالفكرة أنه من الاستفادات لقضية الـ Recombination
+
+612
+01:05:04,900 --> 01:05:11,340
+ومن الاستفادات في بالذات اللي بيسموه الـ
+
+613
+01:05:11,340 --> 01:05:15,560
+Individualized Medicine، يعني إن أنا أحاول أدرس
+
+614
+01:05:15,560 --> 01:05:21,010
+التركيب الجيني تبع الإنسان اللي أمامي، بحيث أفهم هو
+
+615
+01:05:21,010 --> 01:05:26,930
+محتمل أكثر يصيبه إيش، وما يصيبهوش إيش، بهذا الشكل
+
+616
+01:05:26,930 --> 01:05:34,270
+بأستخدم كلمة بدي إياكم تتذكروها، اسمها «Genome-wide
+
+6
+
+667
+01:11:09,620 --> 01:11:16,260
+يعني فالفكرة شبيهة في هذا الحدث، يعني أنه أنا الـ
+
+668
+01:11:16,260 --> 01:11:22,740
+DNA عبارة عن كلمات وأحرف، وكذا. الآن أحياناً الكلمة
+
+669
+01:11:22,740 --> 01:11:26,880
+هذه في بيت الشعر، هذا في البروتين، هذا في القصيدة،
+
+670
+01:11:26,880 --> 01:11:31,950
+الفلانية، أحياناً مش هو نفسه المسبب للمرض 100%. أنا
+
+671
+01:11:31,950 --> 01:11:37,270
+قد لا أكون متأكداً من هذا الموضوع، بس بيظل إنه إذا
+
+672
+01:11:37,270 --> 01:11:41,270
+بقدر أعمل Search لكل إنسان، أو للإنسان اللي بيجي
+
+673
+01:11:41,270 --> 01:11:49,450
+عندي، ماشي، على المستشفى، بكون، شو اسمه؟ بكون عندي
+
+674
+01:11:49,450 --> 01:11:53,590
+آليات أحسن، إني أدرس الموضوع هذا، ماشي؟
+
+675
+01:11:57,130 --> 01:12:01,730
+الموضوع مش إنه أنا بكون واثقاً إن هذا الإنسان راح
+
+676
+01:12:01,730 --> 01:12:05,590
+يصيب المرض الفلاني. ما بقدر أحكي الكلام هذا، الكلام
+
+677
+01:12:05,590 --> 01:12:12,310
+يعني الاستنتاج اللي راح يجي، إنه فيه احتمالية بقدر
+
+678
+01:12:12,310 --> 01:12:18,270
+أعطيها نسب، أو حسب قربها، وحسب الثقة بالنسبة للموضوع.
+
+679
+01:12:18,270 --> 01:12:22,630
+هذا بعطيها نسب، يا إما عالي كتير، يا إما واطي، أو أقل
+
+680
+01:12:22,630 --> 01:12:30,270
+أو كده. ماشي بالنسبة
+
+681
+01:12:30,270 --> 01:12:36,710
+لـ .. يعني أحياناً
+
+682
+01:12:36,710 --> 01:12:42,750
+يعني خلينا نتذكر نقطة، وأنا بأعتبر يعني الأهم هي
+
+683
+01:12:42,750 --> 01:12:47,550
+وجود المفاهيم. إذا أنا شكيت أنه فيه disease
+
+684
+01:12:47,550 --> 01:12:51,450
+chromosomal، أو disease
+
+685
+01:12:52,750 --> 01:12:58,530
+يعني sub-chromosome، أو band فيها مشكلة، شو بدي
+
+686
+01:12:58,530 --> 01:13:03,770
+أعمل؟ إذا أنا شكيت في عائلة عندها شغل زي هيك، بروح
+
+687
+01:13:03,770 --> 01:13:08,910
+بعملهم فحص karyotype. الـ karyotype هو اللي
+
+688
+01:13:08,910 --> 01:13:12,930
+بيخليني أشوف الـ chromosome كله، وبقدر أشوف إذا فيه
+
+689
+01:13:12,930 --> 01:13:19,090
+band ضائعة، band منقولة، band صار فيها مشكلة، وممكن
+
+690
+01:13:19,090 --> 01:13:25,910
+أستفيد من هذا الموضوع كـ Band في تشخيص أشياء معينة،
+
+691
+01:13:25,910 --> 01:13:29,090
+النوع
+
+692
+01:13:29,090 --> 01:13:36,250
+الثاني من عمليات الـ Search، بتكون باستخدام قطعة
+
+693
+01:13:36,250 --> 01:13:44,770
+يعني مثلاً أنا الـ الـ الـ الـ اللي حكينا الـ
+
+694
+01:13:44,770 --> 01:13:52,810
+Nucleotides، زي الأحرف. فلما أجي أعمل Search، بدي على
+
+695
+01:13:52,810 --> 01:14:00,090
+مستوى أن أحط كلمة، ماشي، وأدور عليها. بقدر أسوي هيك.
+
+696
+01:14:00,090 --> 01:14:05,130
+إذا أنا متأكد وين هي، بس أنا عندي تسعة مليارات حرف، و
+
+697
+01:14:05,130 --> 01:14:10,570
+أني أدور فيهم كلهم بهذه الطريقة، أحياناً صعب، و
+
+698
+01:14:10,570 --> 01:14:15,840
+بيبقى عندي احتمالات كبيرة. ولأي إنسان، الـ SNPs اللي
+
+699
+01:14:15,840 --> 01:14:19,840
+هي Single Nucleotide Polymorphism، يعني اختلالات أو
+
+700
+01:14:19,840 --> 01:14:25,300
+اختلافات في Single Nucleotide، عشر ملايين اختلال
+
+701
+01:14:25,300 --> 01:14:31,340
+عادة في أي إنسان منها، فبتصير الأمور صعبة، وبصير
+
+702
+01:14:31,340 --> 01:14:36,900
+يعني أني أكون بثقة، متأكداً من هذا الموضوع، صعب.
+
+703
+01:14:36,900 --> 01:14:40,900
+فالأمور اللي سووها كثير من العلماء، لما ييجوا
+
+704
+01:14:40,900 --> 01:14:46,700
+يدرسوا أمراض معينة ووراثية، بيصير زي مثلاً Retinitis
+
+705
+01:14:46,700 --> 01:14:50,920
+Pigmentosa. هذا النوع من الـ Diseases، Retinitis
+
+706
+01:14:50,920 --> 01:14:56,900
+Pigmentosa، أنا بطلّع لها Marker، يعني أنا بكون درست
+
+707
+01:14:56,900 --> 01:15:03,440
+من قبل وين الجين، وأحياناً بيصعد عليّ أني أشوف، حتى لو
+
+708
+01:15:03,440 --> 01:15:12,680
+يعني حتى لو بشوف أنه في منطقة فيها ارتباط أقوى،
+
+709
+01:15:13,370 --> 01:15:18,210
+أحياناً بكون عندي صعوبة أن أتأكد، أنه هل هو فعلاً
+
+710
+01:15:18,210 --> 01:15:22,350
+هذا الأمر هو المهم. المثال هنا اللي بدي أحطه، نيا
+
+711
+01:15:22,350 --> 01:15:30,650
+اللي هو أنه لما أنت تيجيك حالة، وتيجيك عائلة، أنت
+
+712
+01:15:30,650 --> 01:15:37,770
+بتكون من الـ pedigree، يعني شاكك أن هذا مرض وراثي،
+
+713
+01:15:37,770 --> 01:15:47,810
+وهذا مرض جيني. إذا بالذات، يعني بكون يعني هذا مرض
+
+714
+01:15:47,810 --> 01:15:58,250
+وراثي وجيني، بدي أفكر كيف بدي أجي أنا أعمل الأحسن،
+
+715
+01:15:58,250 --> 01:16:04,730
+أنه أعمل Whole Genome Sequencing، بكون قريت لكل
+
+716
+01:16:04,730 --> 01:16:09,330
+الناس، إذا بالذات أنا بتكلم عن الأسرة اللي عندها
+
+717
+01:16:09,330 --> 01:16:16,210
+المرض، وعندي أفراد مصابين، وأفراد مش مصابين، ماشي؟
+
+718
+01:16:16,210 --> 01:16:20,050
+لما يكون عندي الـ Whole Genome Sequencing، أني
+
+719
+01:16:20,050 --> 01:16:27,910
+أقارن بينهم، أحياناً يعني راح يكون الأمر يعني صعب
+
+720
+01:16:27,910 --> 01:16:35,750
+جداً، حتى على أقوى كمبيوتر، أنه يسوي، ماشي؟ اللي
+
+721
+01:16:35,750 --> 01:16:44,470
+بتتكلموا عنه هنا، إنه افرض أنك لقيت عائلة، وعندك مجموعة
+
+722
+01:16:44,470 --> 01:16:51,450
+أفراد مصابين، ومجموعة أفراد مش مصابين، وقريت الـ
+
+723
+01:16:51,450 --> 01:16:54,650
+Whole
+
+724
+01:16:54,650 --> 01:16:59,370
+جينوم، الـ Sequence تبعهم، وعندك إياهم، وعندك
+
+725
+01:16:59,370 --> 01:17:04,890
+الكمبيوتر زي «جوجل سيرش»، بيقدر يعمل لك البحث، بحيث
+
+726
+01:17:04,890 --> 01:17:10,010
+أنه يقارن بين المصابين وغير المصابين. عندما تكون
+
+727
+01:17:10,010 --> 01:17:17,090
+عمياناً من الأول، تقدر أنه ستجد حوالي أربعة ملايين
+
+728
+01:17:17,090 --> 01:17:23,590
+اختلاف بين المصابين وغير المصابين، يعني هذول عدد
+
+729
+01:17:23,590 --> 01:17:29,150
+هائل جداً من الاختلافات، والاحتمالية الكبرى، يعني
+
+730
+01:17:29,150 --> 01:17:35,930
+إذا تتذكروا كلمة حكيتها من قبل، إن حوالي 94% من الـ
+
+731
+01:17:35,930 --> 01:17:40,390
+DNA في الإنسان هو Non-coding DNA، يعني
+
+732
+01:17:40,390 --> 01:17:44,890
+Intervening DNA، الـ DNA ما لهوش دخل بالـ
+
+733
+01:17:44,890 --> 01:17:49,110
+Transcription و Translation، وتكوين بروتين، ويمكن
+
+734
+01:17:49,110 --> 01:17:53,290
+شوية له دور في الـ Regulation، يعني إذا ما كانش
+
+735
+01:17:53,290 --> 01:17:58,290
+coding 100%، بعضه يعني على أساس بيعتبروه بيحمي ضد
+
+736
+01:17:58,290 --> 01:18:02,540
+الـ Mutations، ولو صارت خراب في هذا المكان، بس هو مش
+
+737
+01:18:02,540 --> 01:18:07,960
+مهم، ما لهوش قيمة. فلما بتقدر أنه فيه أربعة ملايين
+
+738
+01:18:07,960 --> 01:18:16,760
+اختلاف، لما تلاقي، يعني تيجي تحاول تدرس أكثر، مين
+
+739
+01:18:16,760 --> 01:18:22,980
+قريب على بروتين يمكن له وظيفة، مين قريب على منطقة
+
+740
+01:18:22,980 --> 01:18:34,100
+معروفة من قبل، كذا ممكن أحددهم لـ 80 ألف. لما ألاقي
+
+741
+01:18:34,100 --> 01:18:41,300
+الـ 80 ألف اختلاف، بحاول أشوف إذا فيه لهم نتائج
+
+742
+01:18:41,300 --> 01:18:42,940
+على الـ Messenger RNA.
+
+743
+01:18:46,550 --> 01:18:55,770
+بحاول أني أقلل، أو أدرس من الـ Public databases هنا.
+
+744
+01:18:55,770 --> 01:19:02,450
+إذا شفت شيء معروف من قبل، قريب مرتبط مع هذه الحالة،
+
+745
+01:19:02,450 --> 01:19:07,190
+أو هذا المرض، أو شيء قريب منه. وبظلّ بعدين يعني
+
+746
+01:19:07,190 --> 01:19:16,890
+أركز في الدراسة، لحد ما أحاول، إذا بقدر أني أحدد الـ
+
+747
+01:19:16,890 --> 01:19:22,750
+Variants، أحدد ما هي الـ Alleles، أو أكون بينتج عن
+
+748
+01:19:22,750 --> 01:19:27,850
+هذا الجهد كله، بالأخير Segment اللي يمكن نسميه
+
+749
+01:19:27,850 --> 01:19:36,510
+Marker، واللي بيسمّوه Candidate Gene Methodology،
+
+750
+01:19:36,510 --> 01:19:42,070
+يعني اللي هي إني أنا أدور على جين، اللي مرتبط
+
+751
+01:19:42,420 --> 01:19:49,820
+بقوة كاختلاف بين المصابين وبين الطبيعيين، في
+
+752
+01:19:49,820 --> 01:19:57,440
+العائلة هذه، في المرض هذا، في الحالة هذه. يعني شغل
+
+753
+01:19:57,440 --> 01:20:03,940
+نستخدمه، وأحياناً في بعض الأمراض، بعض العائلات، بعض
+
+754
+01:20:03,940 --> 01:20:10,980
+الـ populations، نشتغل هذا الشغل. فمن هذا الشغل، إذا
+
+755
+01:20:11,670 --> 01:20:20,310
+استطعت أجيب Marker متخصص لـ Disease معينة، بصير أنا
+
+756
+01:20:20,310 --> 01:20:24,650
+بعدين أسوي دراسات أخرى، زي الـ Whole Genomes
+
+757
+01:20:24,650 --> 01:20:30,100
+Association، Genome-Wide Association Studies، ماشي،
+
+758
+01:20:30,100 --> 01:20:33,120
+بسوي
+
+759
+01:20:33,120 --> 01:20:37,040
+أشوف إذا الـ Marker هذا موجود، بقول أه والله،
+
+760
+01:20:37,040 --> 01:20:44,660
+احتمالية المرض هذا بنسبة هالقد أكثر من الناس
+
+761
+01:20:44,660 --> 01:20:52,740
+الطبيعية. فهي يعني يعني برجع مرة ثانية، الأهم واحد
+
+762
+01:20:52,740 --> 01:20:56,500
+يكون فاهم المبدأ، يمكن ما يكونش عندنا إمكانية نطبق
+
+763
+01:20:56,500 --> 01:21:04,800
+هذه الأشياء، وصراحة مرات يعني .. يعني بتكون .. شو
+
+764
+01:21:04,800 --> 01:21:10,300
+بدي أسمّيها؟ يعني بتكون مضيعة للقدرات، إن الواحد
+
+765
+01:21:10,300 --> 01:21:14,160
+يدرس أشياء كثيرة، وبيكون زي ما بيقولوا Big Data،
+
+766
+01:21:14,160 --> 01:21:20,240
+يكون عندك أرقام كثيرة، ومعلومات كثيرة. الآن إذا
+
+767
+01:21:20,240 --> 01:21:27,450
+تخيّلنا الـ الـ Google Search مثلاً، كيف بدور لك على
+
+768
+01:21:27,450 --> 01:21:31,530
+الكلمة، وبتجيب لك إياها في أي قصيدة، في أي شيء قدر
+
+769
+01:21:31,530 --> 01:21:38,770
+هو مفيد. ممكن، بس هي الفكرة إن هذا الموضوع لسه
+
+770
+01:21:38,770 --> 01:21:46,470
+بحاجة لتطوير أكثر، مشاركة أكثر، وانتباه للاختلافات،
+
+771
+01:21:46,980 --> 01:21:55,100
+يعني حتى لو لقينا شيء يمكن زابط كنسبة في الأمر، كما
+
+772
+01:21:55,100 --> 01:22:00,260
+في البيض، في السود، في كده، قد لا يكون بالضرورة هو
+
+773
+01:22:00,260 --> 01:22:07,580
+اللي عندنا إحنا كمثلاً عرب، أو في منطقة الشرق الأوسط،
+
+774
+01:22:07,580 --> 01:22:12,560
+أو بلاد الشام، أو كده. يعني هذه اختلافات، بدي الواحد
+
+775
+01:22:12,560 --> 01:22:18,840
+ينتبه إليها. الأهم من هيك، يكون الواحد عنده تصور
+
+776
+01:22:18,840 --> 01:22:26,720
+على معنى اللي بيقرأه وبيشوفه. لما نتكلموا على إن
+
+777
+01:22:26,720 --> 01:22:31,600
+هذا Marker لـ Disease، يعني يفهمها الواحد. ونتيجة
+
+778
+01:22:31,600 --> 01:22:36,480
+الـ Marker، نتيجة حدوث ظاهرة الـ Recombination، و
+
+779
+01:22:36,480 --> 01:22:41,200
+الـ Crossover، والـ Linkage Disequilibrium، في
+
+780
+01:22:41,200 --> 01:22:46,280
+تفاوت بين الـ Markers، يعني قد لا يكون الـ Marker
+
+781
+01:22:46,280 --> 01:22:52,700
+اللي بتستخدمه هو السليم. أحكوا، ده فيه أسئلة؟ إيه،
+
+782
+01:22:52,700 --> 01:22:57,820
+كريم بده يتكلم في استفسارين؟ نعم، فضل يا كريم.
+
+783
+01:22:57,820 --> 01:23:01,380
+باعرض لك
+
+784
+01:23:01,380 --> 01:23:04,560
+صورة في الـ chats، ممكن برضه مقال، ممكن تعرف شوفها
+
+785
+01:23:04,560 --> 01:23:10,600
+شول أحكيها؟ أحكيها كمبدأ يعني، ما الصورة هيك، أثبت ده
+
+786
+01:23:10,600 --> 01:23:20,380
+قد أنزله كده. لأن جيتها في الـ «Pedigree» - أه - في
+
+787
+01:23:20,380 --> 01:23:24,480
+حالة الـ «Pedigree» - أه - لما تكون مثلاً في ميل
+
+788
+01:23:24,480 --> 01:23:27,460
+محطوم، تحتها، ساهم واحد - أه - بدون ما تكون عاملة
+
+789
+01:23:27,460 --> 01:23:37,800
+تزاوج - أه - مع ميل آخر - خليني أشوف - أه -
+
+790
+01:23:37,800 --> 01:23:40,160
+عرضت الصورة أنا يا دكتور - أه - حملتها وعرضتها
+
+791
+01:23:40,160 --> 01:23:47,470
+أنا - أه، هي موجودة أكتر من قديم، مش الموضوع الـ X
+
+792
+01:23:47,470 --> 01:23:52,410
+-linked dominant inheritance disorder. الـ X-linked
+
+793
+01:23:52,410 --> 01:23:52,530
+dominant inheritance disorder. الـ X-linked
+
+794
+01:23:52,530 --> 01:23:54,270
+dominant inheritance disorder. الـ X-linked
+
+795
+01:23:54,270 --> 01:23:54,490
+dominant inheritance disorder. الـ X-linked
+
+796
+01:23:54,490 --> 01:23:56,190
+dominant inheritance disorder. الـ X-linked
+
+797
+01:23:56,190 --> 01:23:56,510
+dominant inheritance disorder. الـ X-linked
+
+798
+01:23:56,510 --> 01:23:56,930
+dominant inheritance disorder. الـ X-linked
+
+799
+01:23:56,930 --> 01:23:58,890
+dominant inheritance disorder. الـ X-linked
+
+800
+01:23:58,890 --> 01:23:58,970
+dominant inheritance disorder. الـ X-linked
+
+801
+01:23:58,970 --> 01:23:59,090
+dominant inheritance disorder. الـ X-linked
+
+802
+01:23:59,090 --> 01:23:59,350
+dominant inheritance disorder. الـ X-linked
+
+803
+01:23:59,350 --> 01:23:59,750
+dominant inheritance disorder. الـ X-linked
+
+804
+01:23:59,750 --> 01:24:01,270
+dominant inheritance disorder. الـ X-linked
+
+805
+01:24:01,270 --> 01:24:04,210
+dominant inheritance disorder. الـ X-linked
+
+806
+01:24:04,210 --> 01:24:06,890
+dominant inheritance disorder. الـ X-linked
+
+807
+01:24:06,890 --> 01:24:09,260
+dominant inheritance disorder. الـ X-linked لما
+
+808
+01:24:09,260 --> 01:24:12,080
+يعطيك حالة في الحالة هذه، يقول لك اللي هو ال female
+
+809
+01:24:12,080 --> 01:24:16,480
+أنا أزوجها، اللي معها يكون أعتبره دائماً سليم، ولا
+
+810
+01:24:16,480 --> 01:24:24,000
+ممكن يكون mutant عادي؟ ما هو ليش ما حطّهاش؟ لأنه
+
+811
+01:24:24,000 --> 01:24:31,400
+ما عنديش معلومة، فاهم عليّ كيف؟ يعني هنا الـ بكثير
+
+812
+01:24:31,400 --> 01:24:33,080
+إحسانات، نعم.
+
+813
+01:24:36,400 --> 01:24:40,700
+كثير في صور زيك في الكتاب، بيكون حاطّ كل .. بقول لك
+
+814
+01:24:40,700 --> 01:24:43,620
+كثير في صور تكون في الكتاب، حاطّة نفس الـ .. الوصف
+
+815
+01:24:43,620 --> 01:24:47,060
+نفسها، معيّن في degree، وعمل بس، أفرض زيك من دون أن
+
+816
+01:24:47,060 --> 01:24:50,880
+يعمل تزاوج، فاهمة إنّه .. هذه بتكون الـ .. إنه مش
+
+817
+01:24:50,880 --> 01:24:53,960
+عارف الـ الـ الـ الـ الـ الـ الـ الـ
+
+818
+01:24:53,960 --> 01:24:55,520
+الـ الـ الـ الـ الـ الـ الـ الـ
+
+819
+01:24:55,520 --> 01:24:55,800
+الـ الـ الـ الـ الـ الـ الـ الـ
+
+820
+01:24:55,800 --> 01:24:58,640
+الـ الـ الـ الـ الـ الـ الـ الـ
+
+821
+01:24:58,640 --> 01:24:58,960
+الـ الـ الـ الـ الـ الـ الـ الـ
+
+822
+01:24:58,960 --> 01:25:00,020
+الـ الـ الـ الـ الـ الـ الـ الـ
+
+823
+01:25:00,020 --> 01:25:00,420
+الـ الـ الـ الـ الـ الـ الـ الـ
+
+824
+01:25:00,420 --> 01:25:08,610
+الـ الـ الـ الـ الما وصلتوش، فاهم عليّ؟ يعني
+
+825
+01:25:08,610 --> 01:25:16,050
+أنا جيت عملت دراسة على عائلة معينة، والأبو مسافر،
+
+826
+01:25:16,050 --> 01:25:21,750
+مش في البلد، مش في المنطقة، فأه الفكرة إنه ما عنديش
+
+827
+01:25:21,750 --> 01:25:25,930
+معلومة عنه، بس طبعاً لازم عشان خلّفت، لازم اتزوجت
+
+828
+01:25:25,930 --> 01:25:33,350
+مع شخص آخر، و بفترض أنه سليم، ماشي؟ لو كنت عرفت
+
+829
+01:25:33,350 --> 01:25:38,690
+منها إنه مصاب بنفس الإصابة، بدا أحطه، بس الفكرة
+
+830
+01:25:38,690 --> 01:25:44,890
+هنا إنه هذه كـ Disease، أو بـ degree لظاهرة، إنه إذا
+
+831
+01:25:44,890 --> 01:25:50,710
+في صفة X-linked dominant، إذا الـ X-linked dominant،
+
+832
+01:25:50,710 --> 01:25:55,850
+إحنا عادة نتكلم X-linked recessive، الـ X-linked
+
+833
+01:25:55,850 --> 01:26:01,910
+dominant، الأنثى لو عندها نسخة واحدة، بتلاقيها يعني
+
+834
+01:26:01,910 --> 01:26:07,230
+نسخة واحدة مصابة، والثانية سليمة، بتلاقيها بنتج على
+
+835
+01:26:07,230 --> 01:26:14,550
+أنه عندها المرض، بينما الذكر لما يكون مصاب، ماشي، بس
+
+836
+01:26:14,550 --> 01:26:18,950
+ما عندهوش نسخة ثانية تكون سليمة، يعني تمشّيه. فاللي
+
+837
+01:26:18,950 --> 01:26:24,330
+بيصير عنده زي هيك الـ Inheritance، بيكون أنه الذكر
+
+838
+01
\ No newline at end of file
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/ofPBC5zCpyc_raw.json b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/ofPBC5zCpyc_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..a5e4047407e11a0edc7531e9a5531fe978fab6be
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/ofPBC5zCpyc_raw.json
@@ -0,0 +1 @@
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"end": 394.48, "word": " ..", "probability": 0.7431640625}, {"start": 394.48, "end": 397.08, "word": " اثنين", "probability": 0.846435546875}, {"start": 397.08, "end": 397.48, "word": " هم", "probability": 0.9013671875}], "temperature": 1.0}, {"id": 15, "seek": 42554, "start": 399.42, "end": 425.54, "text": "زلمة ومرة عندهم أكندربلازيا وكانت أنا فحصتهم ولقيتهم dominant ولقيت two copies الأصل لو فيه two copies ماشي يعني لو بقدر واحد يحسبها لو واحد بس شخص مصعب الاحتمالي المفروض تكون نص بس إذا اثنين مصعبين لازم تكون أكتر واحتمال", "tokens": [11622, 19528, 3660, 4032, 29973, 3660, 43242, 16095, 5551, 19452, 3215, 2288, 36150, 31377, 25528, 4032, 41361, 2655, 41850, 6156, 5016, 9381, 2655, 16095, 4032, 1211, 4587, 36081, 16095, 15657, 4032, 1211, 4587, 36081, 732, 14341, 16247, 36520, 45164, 8978, 3224, 732, 14341, 3714, 33599, 1829, 37495, 22653, 45164, 4724, 28543, 2288, 36764, 24401, 7251, 5016, 35457, 11296, 45164, 36764, 24401, 4724, 3794, 13412, 9778, 9381, 3714, 9381, 3615, 3555, 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"word": " يجب", "probability": 0.6892903645833334}, {"start": 470.33, "end": 470.39, "word": " أن", "probability": 0.68994140625}, {"start": 470.39, "end": 470.43, "word": " يكون", "probability": 0.843017578125}, {"start": 470.43, "end": 470.69, "word": " الواحد", "probability": 0.6834716796875}, {"start": 470.69, "end": 472.27, "word": " يتكلم", "probability": 0.9359130859375}, {"start": 472.27, "end": 472.53, "word": " على", "probability": 0.414306640625}, {"start": 472.53, "end": 472.87, "word": " إنه", "probability": 0.89697265625}, {"start": 472.87, "end": 473.13, "word": " فيه", "probability": 0.3953857421875}, {"start": 473.13, "end": 473.73, "word": " Incomplete", "probability": 0.740478515625}, {"start": 473.73, "end": 474.47, "word": " Dominance", "probability": 0.790771484375}, {"start": 474.47, "end": 476.21, "word": " ماشي،", "probability": 0.71331787109375}, {"start": 476.21, "end": 476.39, "word": " أو", "probability": 0.08966064453125}, {"start": 476.39, "end": 476.59, 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" فاهم", "probability": 0.8084309895833334}, {"start": 741.54, "end": 742.56, "word": " عليك؟", "probability": 0.6551106770833334}, {"start": 742.56, "end": 742.74, "word": " ألا", "probability": 0.457763671875}, {"start": 742.74, "end": 743.06, "word": " لما", "probability": 0.828369140625}, {"start": 743.06, "end": 743.76, "word": " يكونوا", "probability": 0.9446614583333334}, {"start": 743.76, "end": 744.04, "word": " زي", "probability": 0.972900390625}, {"start": 744.04, "end": 744.34, "word": " هي", "probability": 0.74658203125}], "temperature": 1.0}, {"id": 27, "seek": 77440, "start": 745.16, "end": 774.4, "text": "توقعنا إنه الـ 75% من الـ من الأطفال اللي بيطلعوا راح يكونوا برضه أكندربلازيا ماشي، واللي عنده 25% اللي هي الـ 25% اللي هي الـ Double اللي بيكون homozygous، dominant", "tokens": [2655, 30543, 3615, 8315, 36145, 3224, 2423, 39184, 9562, 4, 9154, 2423, 39184, 9154, 16247, 9566, 5172, 6027, 13672, 1829, 4724, 1829, 9566, 1211, 3615, 14407, 12602, 39319, 7251, 30544, 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Deactivation عند الثمن آه، مش كله بيحصل Deactivation بيحصل Expiration لبعض جينات المنسية لأ، المقصود في الـ Random Deactivation للجينات اللي احنا بنحكي عنه الـ Ionization بتلاقي الجين كامل مش شغال، مش مفروض", "tokens": [6027, 39184, 1721, 40934, 423, 1783, 5296, 15042, 7251, 5016, 36520, 1346, 23397, 399, 43242, 6024, 104, 27842, 19753, 3224, 12399, 37893, 28242, 3224, 4724, 1829, 5016, 36520, 1346, 23397, 399, 4724, 1829, 5016, 36520, 21391, 7611, 5296, 3555, 3615, 11242, 10874, 1829, 8315, 2655, 9673, 1863, 3794, 10632, 5296, 10721, 12399, 9673, 4587, 9381, 23328, 8978, 2423, 39184, 37603, 1346, 23397, 399, 24976, 7435, 1829, 8315, 2655, 13672, 1829, 1975, 5016, 8315, 44945, 5016, 4117, 1829, 18871, 3224, 2423, 39184, 286, 266, 2144, 39894, 15040, 38436, 25724, 9957, 9122, 10943, 1211, 37893, 13412, 17082, 6027, 12399, 37893, 3714, 5172, 32887, 11242], "avg_logprob": -0.2689623769047191, "compression_ratio": 1.6388888888888888, "no_speech_prob": 2.384185791015625e-07, "words": 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1219.66, "word": " in", "probability": 0.953125}, {"start": 1219.66, "end": 1220.28, "word": " this", "probability": 0.94482421875}, {"start": 1220.28, "end": 1222.04, "word": " population؟", "probability": 0.853515625}], "temperature": 1.0}, {"id": 44, "seek": 125083, "start": 1223.15, "end": 1250.83, "text": "هنا عقدت الموضوع زيادة يعني لو الـ AB كان كله يعني الـ AB لو إنه كان موجود بهذا الشكل يعني لو كان كروموزومت أليل واحد كانت راح تكون تماماً Classical حسب المعادلات بس هنا أنا حطيت الأثنين فكروا فيها", "tokens": [3224, 8315, 6225, 28543, 2655, 9673, 2407, 11242, 45367, 30767, 1829, 18513, 3660, 37495, 22653, 45164, 2423, 39184, 13838, 25961, 28242, 3224, 37495, 22653, 2423, 39184, 13838, 45164, 36145, 3224, 25961, 3714, 29245, 23328, 39627, 15730, 25124, 28820, 37495, 22653, 45164, 25961, 9122, 2288, 20498, 2407, 11622, 20498, 2655, 5551, 20292, 1211, 36764, 24401, 25961, 2655, 12602, 39319, 6055, 30544, 46811, 10943, 995, 14111, 9471, 804, 11331, 35457, 9673, 3615, 18513, 1211, 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1229.51, "end": 1230.83, "word": " كله", "probability": 0.943603515625}, {"start": 1230.83, "end": 1233.03, "word": " يعني", "probability": 0.87255859375}, {"start": 1233.03, "end": 1233.27, "word": " الـ", "probability": 0.959228515625}, {"start": 1233.27, "end": 1233.59, "word": " AB", "probability": 0.9013671875}, {"start": 1233.59, "end": 1233.91, "word": " لو", "probability": 0.98291015625}, {"start": 1233.91, "end": 1234.61, "word": " إنه", "probability": 0.6864013671875}, {"start": 1234.61, "end": 1235.81, "word": " كان", "probability": 0.9833984375}, {"start": 1235.81, "end": 1237.11, "word": " موجود", "probability": 0.9825846354166666}, {"start": 1237.11, "end": 1237.69, "word": " بهذا", "probability": 0.9521484375}, {"start": 1237.69, "end": 1238.25, "word": " الشكل", "probability": 0.993896484375}, {"start": 1238.25, "end": 1239.11, "word": " يعني", "probability": 0.9658203125}, {"start": 1239.11, "end": 1239.31, "word": " لو", "probability": 0.974609375}, {"start": 1239.31, 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الأبناء والبنات ماشي أحياناً يعني باعتمد على بالذات إذا الأماكن بعيدة عن بعض ماشي، في الـ DNA", "tokens": [2407, 3615, 8315, 28242, 36764, 24401, 9154, 11296, 4453, 14341, 5296, 15042, 41850, 4724, 26108, 1829, 47525, 2288, 3794, 6055, 2288, 31371, 3555, 25724, 1829, 8315, 2655, 6055, 3555, 3615, 9307, 16247, 3555, 1863, 16606, 16070, 3555, 8315, 2655, 3714, 33599, 1829, 5551, 5016, 1829, 7649, 995, 14111, 37495, 22653, 4724, 995, 34268, 2304, 3215, 15844, 20666, 8848, 9307, 11933, 15730, 16247, 15042, 19452, 45030, 25708, 3660, 18871, 45030, 11242, 3714, 33599, 1829, 12399, 8978, 2423, 39184, 8272], "avg_logprob": -0.19066455847100366, "compression_ratio": 1.5414364640883977, "no_speech_prob": 5.960464477539062e-07, "words": [{"start": 1369.52, "end": 1369.98, "word": "وعنا", "probability": 0.5927734375}, {"start": 1369.98, "end": 1370.26, "word": " كل", "probability": 0.9462890625}, {"start": 1370.26, "end": 1370.54, "word": " واحد", "probability": 0.989501953125}, {"start": 1370.54, 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ماشي،", "probability": 0.7406005859375}, {"start": 1394.62, "end": 1394.94, "word": " في", "probability": 0.919921875}, {"start": 1394.94, "end": 1395.26, "word": " الـ", "probability": 0.904052734375}, {"start": 1395.26, "end": 1395.48, "word": " DNA", "probability": 0.486083984375}], "temperature": 1.0}, {"id": 50, "seek": 142568, "start": 1396.46, "end": 1425.68, "text": "بلاقي إنه بتصير ظاهرة بنسميها الـ recombination الـ recombination إنه بيصير خلال فترات الـ cell division بيبدأ تكون بالـ gametes يعني بالـ ova و بالـ sperms لما يصير عملية الـ segregation لما يصير عملية الانفصال", "tokens": [3555, 15040, 38436, 36145, 3224, 39894, 9381, 13546, 1357, 116, 40294, 25720, 44945, 38251, 1829, 11296, 2423, 39184, 850, 3548, 2486, 2423, 39184, 850, 3548, 2486, 36145, 3224, 4724, 1829, 9381, 13546, 16490, 1211, 6027, 6156, 2655, 2288, 9307, 2423, 39184, 2815, 10044, 4724, 1829, 44510, 10721, 6055, 30544, 20666, 39184, 8019, 37996, 37495, 22653, 20666, 39184, 277, 2757, 4032, 20666, 39184, 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1401.58, "end": 1402.4, "word": " recombination", "probability": 0.9168294270833334}, {"start": 1402.4, "end": 1404.44, "word": " إنه", "probability": 0.714111328125}, {"start": 1404.44, "end": 1405.5, "word": " بيصير", "probability": 0.8780517578125}, {"start": 1405.5, "end": 1407.0, "word": " خلال", "probability": 0.9969075520833334}, {"start": 1407.0, "end": 1409.46, "word": " فترات", "probability": 0.8931884765625}, {"start": 1409.46, "end": 1410.46, "word": " الـ", "probability": 0.864013671875}, {"start": 1410.46, "end": 1410.72, "word": " cell", "probability": 0.8623046875}, {"start": 1410.72, "end": 1411.34, "word": " division", "probability": 0.96875}, {"start": 1411.34, "end": 1413.82, "word": " بيبدأ", "probability": 0.53466796875}, {"start": 1413.82, "end": 1414.1, "word": " تكون", "probability": 0.9619140625}, {"start": 1414.1, "end": 1414.34, "word": " بالـ", "probability": 0.90234375}, {"start": 1414.34, "end": 1414.94, "word": " gametes", "probability": 0.954833984375}, {"start": 1414.94, "end": 1415.36, "word": " يعني", "probability": 0.85009765625}, {"start": 1415.36, "end": 1415.74, "word": " بالـ", "probability": 0.933837890625}, {"start": 1415.74, "end": 1416.16, "word": " ova", "probability": 0.708984375}, {"start": 1416.16, "end": 1416.94, "word": " و", "probability": 0.61474609375}, {"start": 1416.94, "end": 1417.6, "word": " بالـ", "probability": 0.912109375}, {"start": 1417.6, "end": 1418.48, "word": " sperms", "probability": 0.729248046875}, {"start": 1418.48, "end": 1419.44, "word": " لما", "probability": 0.908935546875}, {"start": 1419.44, "end": 1419.86, "word": " يصير", "probability": 0.94873046875}, {"start": 1419.86, "end": 1420.3, "word": " عملية", "probability": 0.982421875}, {"start": 1420.3, "end": 1420.52, "word": " الـ", "probability": 0.919677734375}, {"start": 1420.52, "end": 1420.92, "word": " segregation", "probability": 0.90283203125}, {"start": 1420.92, "end": 1421.64, "word": " لما", "probability": 0.96875}, {"start": 1421.64, "end": 1421.92, "word": " يصير", "probability": 0.99267578125}, {"start": 1421.92, "end": 1422.52, "word": " عملية", "probability": 0.9755859375}, {"start": 1422.52, "end": 1425.68, "word": " الانفصال", "probability": 0.890625}], "temperature": 1.0}, {"id": 51, "seek": 145464, "start": 1426.02, "end": 1454.64, "text": "الـ Two copies عن بعضها، ماشي؟ شو اسمه؟ بالنسبة ل، لو فرضنا هنا، هاي بدهم يطلعوا على الـDNA بالذات للـX-Chromosome مثلا بالنسبة للإنسان هذا", "tokens": [6027, 39184, 4453, 14341, 18871, 45030, 11242, 11296, 12399, 3714, 33599, 1829, 22807, 13412, 2407, 24525, 2304, 3224, 22807, 20666, 1863, 35457, 3660, 5296, 12399, 45164, 6156, 43042, 8315, 34105, 12399, 8032, 47302, 47525, 16095, 7251, 9566, 1211, 3615, 14407, 15844, 2423, 39184, 35, 5321, 20666, 8848, 9307, 24976, 39184, 55, 12, 11644, 40934, 423, 50113, 15040, 20666, 1863, 35457, 3660, 24976, 28814, 1863, 3794, 7649, 23758], "avg_logprob": -0.23104319568066037, "compression_ratio": 1.3668639053254439, 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"end": 1441.28, "word": " فرضنا", "probability": 0.99365234375}, {"start": 1441.28, "end": 1442.58, "word": " هنا،", "probability": 0.604736328125}, {"start": 1442.58, "end": 1443.1, "word": " هاي", "probability": 0.65478515625}, {"start": 1443.1, "end": 1443.64, "word": " بدهم", "probability": 0.663818359375}, {"start": 1443.64, "end": 1444.46, "word": " يطلعوا", "probability": 0.88251953125}, {"start": 1444.46, "end": 1445.0, "word": " على", "probability": 0.9462890625}, {"start": 1445.0, "end": 1446.72, "word": " الـDNA", "probability": 0.81683349609375}, {"start": 1446.72, "end": 1447.62, "word": " بالذات", "probability": 0.9044596354166666}, {"start": 1447.62, "end": 1449.12, "word": " للـX", "probability": 0.8419596354166666}, {"start": 1449.12, "end": 1449.88, "word": "-Chromosome", "probability": 0.77978515625}, {"start": 1449.88, "end": 1450.4, "word": " مثلا", "probability": 0.927978515625}, {"start": 1450.4, "end": 1451.14, "word": " بالنسبة", "probability": 0.9090576171875}, {"start": 1451.14, "end": 1454.24, "word": " للإنسان", "probability": 0.93408203125}, {"start": 1454.24, "end": 1454.64, "word": " هذا", "probability": 0.98583984375}], "temperature": 1.0}, {"id": 52, "seek": 148458, "start": 1455.28, "end": 1484.58, "text": "بنلاقي إنه صحيح حجم الـ «DNA» كاملاً هيك متساوي ويعني متشابه بس حقيقةً في قطع في كل كروموزوم بيكون من الـ يعني من النسختين اللي قبل يعني هسة الـ «high»", "tokens": [3555, 1863, 15040, 38436, 36145, 3224, 20328, 5016, 1829, 5016, 11331, 7435, 2304, 2423, 39184, 4657, 35, 5321, 5933, 9122, 10943, 15040, 14111, 39896, 4117, 44650, 3794, 995, 45865, 4032, 40228, 22653, 44650, 8592, 16758, 3224, 4724, 3794, 11331, 38436, 28671, 14111, 8978, 12174, 9566, 3615, 8978, 28242, 9122, 2288, 20498, 2407, 11622, 20498, 4724, 1829, 30544, 9154, 2423, 39184, 37495, 22653, 9154, 28239, 3794, 46456, 9957, 13672, 1829, 12174, 36150, 37495, 22653, 8032, 3794, 3660, 2423, 39184, 4657, 21454, 5933], "avg_logprob": -0.1863567029557577, "compression_ratio": 1.5739644970414202, "no_speech_prob": 4.172325134277344e-07, "words": [{"start": 1455.28, "end": 1455.98, "word": "بنلاقي", "probability": 0.798828125}, {"start": 1455.98, "end": 1457.1, "word": " إنه", "probability": 0.760498046875}, {"start": 1457.1, "end": 1459.66, "word": " صحيح", "probability": 0.9896240234375}, {"start": 1459.66, "end": 1460.08, "word": " حجم", "probability": 0.9832356770833334}, {"start": 1460.08, "end": 1460.3, "word": " الـ", "probability": 0.986572265625}, {"start": 1460.3, "end": 1460.9, "word": " «DNA»", "probability": 0.7882080078125}, {"start": 1460.9, "end": 1461.56, "word": " كاملاً", "probability": 0.8719482421875}, {"start": 1461.56, "end": 1461.86, "word": " هيك", "probability": 0.650390625}, {"start": 1461.86, "end": 1462.74, "word": " متساوي", "probability": 0.964599609375}, {"start": 1462.74, "end": 1465.92, "word": " ويعني", "probability": 0.7577311197916666}, {"start": 1465.92, "end": 1466.9, "word": " متشابه", "probability": 0.9949951171875}, {"start": 1466.9, "end": 1467.88, "word": " بس", "probability": 0.91064453125}, {"start": 1467.88, "end": 1469.54, "word": " حقيقةً", "probability": 0.884521484375}, {"start": 1469.54, "end": 1469.94, "word": " في", "probability": 0.81982421875}, {"start": 1469.94, "end": 1470.52, "word": " قطع", "probability": 0.9228515625}, {"start": 1470.52, "end": 1470.88, "word": " في", "probability": 0.9716796875}, {"start": 1470.88, "end": 1471.42, "word": " كل", "probability": 0.994140625}, {"start": 1471.42, "end": 1473.22, "word": " كروموزوم", "probability": 0.7405192057291666}, {"start": 1473.22, "end": 1474.94, "word": " بيكون", "probability": 0.8369140625}, {"start": 1474.94, "end": 1475.42, "word": " من", "probability": 0.97509765625}, {"start": 1475.42, "end": 1477.58, "word": " الـ", "probability": 0.7060546875}, {"start": 1477.58, "end": 1478.52, "word": " يعني", "probability": 0.79248046875}, {"start": 1478.52, "end": 1478.8, "word": " من", "probability": 0.9931640625}, {"start": 1478.8, "end": 1479.7, "word": " النسختين", "probability": 0.9100341796875}, {"start": 1479.7, "end": 1480.14, "word": " اللي", "probability": 0.970947265625}, {"start": 1480.14, "end": 1480.58, "word": " قبل", "probability": 0.993896484375}, {"start": 1480.58, "end": 1481.6, "word": " يعني", "probability": 0.90869140625}, {"start": 1481.6, "end": 1482.7, "word": " هسة", "probability": 0.553466796875}, {"start": 1482.7, "end": 1483.84, "word": " الـ", "probability": 0.96826171875}, {"start": 1483.84, "end": 1484.58, "word": " «high»", "probability": 0.69482421875}], "temperature": 1.0}, {"id": 53, "seek": 150718, "start": 1484.78, "end": 1507.18, "text": "الصور الأصلية للـChromosomes تبعات ذكر الأمتى عندما نأخذ البنت الأولى هذا الـChromosome أخذته من أبوها بس صحيح كان في الغالب", "tokens": [6027, 9381, 13063, 16247, 9381, 20292, 3660, 24976, 39184, 11644, 40934, 18168, 6055, 3555, 3615, 9307, 29910, 37983, 16247, 2304, 49975, 43242, 15042, 8717, 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من ثلاثة كانت موجودة بينما الـ capital A موجودة في غالبية اللي ماعندهم مش الـ disease فاللي بنقوله هنا يعني الـ conclusion أنه الـ الـ marker B ماشي", "tokens": [6027, 39184, 2423, 39184, 2423, 39184, 25961, 16247, 36520, 4238, 316, 6055, 30544, 3714, 29245, 23328, 3660, 4724, 3794, 5551, 12984, 1863, 9957, 9154, 38637, 1211, 5718, 104, 3660, 25961, 2655, 3714, 29245, 23328, 3660, 49374, 15042, 2423, 39184, 4238, 316, 3714, 29245, 23328, 3660, 8978, 32771, 6027, 3555, 10632, 13672, 1829, 19446, 3615, 41260, 16095, 37893, 2423, 39184, 4752, 6156, 6027, 20292, 44945, 39648, 3224, 34105, 37495, 22653, 2423, 39184, 10063, 14739, 3224, 2423, 39184, 2423, 39184, 15247, 363, 3714, 33599, 1829], "avg_logprob": -0.15904017644269125, "compression_ratio": 1.732620320855615, "no_speech_prob": 1.1920928955078125e-06, "words": [{"start": 2608.59, "end": 2609.59, "word": "الـ", "probability": 0.685791015625}, {"start": 2609.59, "end": 2612.13, "word": " الـ", "probability": 0.5802001953125}, 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3112.56, "text": "تفاصيلها كيف كل واحدة يعني شون الـ non-recombinant و الـ recoisant و الـ recombinant هدولة أثنتين زي بعض بس المهم أنه جلب صارت عملية recombination هنا ماشي بس إذا كانوا قريبين على بعض", "tokens": [2655, 5172, 33546, 26895, 11296, 9122, 33911, 28242, 36764, 24401, 3660, 37495, 22653, 13412, 11536, 2423, 39184, 2107, 12, 265, 1112, 13496, 394, 4032, 2423, 39184, 850, 78, 3837, 580, 4032, 2423, 39184, 850, 3548, 259, 394, 8032, 3215, 12610, 3660, 5551, 12984, 29399, 9957, 30767, 1829, 45030, 11242, 4724, 3794, 9673, 16095, 14739, 3224, 10874, 46152, 20328, 9640, 2655, 6225, 42213, 10632, 850, 3548, 2486, 34105, 3714, 33599, 1829, 4724, 3794, 11933, 15730, 25961, 14407, 12174, 16572, 3555, 9957, 15844, 45030, 11242], "avg_logprob": -0.2892485090664455, "compression_ratio": 1.5376344086021505, "no_speech_prob": 0.0, "words": [{"start": 3090.98, "end": 3091.92, "word": "تفاصيلها", "probability": 0.7111328125}, {"start": 3091.92, "end": 3092.28, "word": " كيف", 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صار عندي Crossing Over بس الـ Recombination هي المحصلة النهائية لما يكونوا Balanced لما يكونوا متوازنين لما تكون يعني", "tokens": [3555, 1829, 30544, 8592, 44650, 3794, 995, 45865, 34051, 25062, 9566, 3615, 16070, 1211, 12984, 4587, 12602, 39319, 7251, 29399, 7435, 18871, 3224, 36145, 3224, 8978, 3224, 12174, 9566, 27884, 9122, 3555, 48923, 30767, 1829, 18513, 3660, 4032, 41185, 3224, 12174, 9566, 27884, 20328, 17082, 48923, 6156, 3224, 8315, 13412, 2407, 20328, 9640, 18871, 16254, 22807, 34105, 20328, 9640, 18871, 16254, 41675, 4886, 4724, 3794, 2423, 39184, 1300, 38763, 2486, 39896, 9673, 5016, 36520, 3660, 28239, 3224, 16373, 10632, 5296, 15042, 7251, 30544, 14407, 13140, 4864, 5296, 15042, 7251, 30544, 14407, 44650, 2407, 31377, 1863, 9957, 5296, 15042, 6055, 30544, 37495, 22653], "avg_logprob": -0.17657767597911428, "compression_ratio": 1.654867256637168, "no_speech_prob": 2.5033950805664062e-06, "words": [{"start": 3647.66, "end": 3648.18, "word": "بيكونش", "probability": 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"end": 4496.9, "word": " درست", "probability": 0.9869791666666666}, {"start": 4496.9, "end": 4497.12, "word": " من", "probability": 0.9951171875}, {"start": 4497.12, "end": 4497.56, "word": " قبل", "probability": 0.995361328125}, {"start": 4497.56, "end": 4498.64, "word": " وين", "probability": 0.895263671875}, {"start": 4498.64, "end": 4499.18, "word": " الجين", "probability": 0.69970703125}, {"start": 4499.18, "end": 4499.9, "word": " وأحيانًا", "probability": 0.896240234375}, {"start": 4499.9, "end": 4500.3, "word": " صعد", "probability": 0.4722900390625}, {"start": 4500.3, "end": 4500.92, "word": " علي", "probability": 0.76318359375}, {"start": 4500.92, "end": 4501.76, "word": " أني", "probability": 0.6710205078125}, {"start": 4501.76, "end": 4502.26, "word": " أشوف", "probability": 0.9866536458333334}, {"start": 4502.26, "end": 4503.06, "word": " حتى", "probability": 0.94921875}, {"start": 4503.06, "end": 4503.44, "word": " لو", "probability": 0.9970703125}, {"start": 4503.44, "end": 4506.22, "word": " يعني", "probability": 0.920166015625}, {"start": 4506.22, "end": 4508.6, "word": " حتى", "probability": 0.964599609375}, {"start": 4508.6, "end": 4508.9, "word": " لو", "probability": 0.998046875}, {"start": 4508.9, "end": 4509.58, "word": " بشوف", "probability": 0.9903971354166666}, {"start": 4509.58, "end": 4510.24, "word": " أنه", "probability": 0.69189453125}, {"start": 4510.24, "end": 4510.5, "word": " في", "probability": 0.97216796875}, {"start": 4510.5, "end": 4511.16, "word": " منطقة", "probability": 0.9698893229166666}, {"start": 4511.16, "end": 4511.48, "word": " فيها", "probability": 0.97265625}, {"start": 4511.48, "end": 4512.1, "word": " ارتباط", "probability": 0.858154296875}, {"start": 4512.1, "end": 4512.68, "word": " أقوى", "probability": 0.9610595703125}], "temperature": 1.0}, {"id": 162, "seek": 454010, "start": 4513.37, "end": 4540.11, "text": "أحياناً بكون عندي صعوبة أن أتأكد أنه هل هو فعلاً هذا الأمر هو المهم المثال هنا اللي بدي أحطهنيا اللي هو أنه لما أنت تيجيك حالة وتيجيك عيلة أنت بتكون من الـ pedigree يعني شاكك أن هذا مرض وراثي وهذا مرض جيني", "tokens": [10721, 5016, 1829, 7649, 995, 14111, 4724, 30544, 18871, 16254, 20328, 3615, 37746, 3660, 14739, 5551, 2655, 10721, 4117, 3215, 14739, 3224, 8032, 1211, 31439, 6156, 3615, 15040, 14111, 23758, 16247, 29973, 31439, 9673, 16095, 9673, 12984, 6027, 34105, 13672, 1829, 4724, 16254, 5551, 5016, 9566, 3224, 1863, 25528, 13672, 1829, 31439, 14739, 3224, 5296, 15042, 14739, 2655, 6055, 1829, 7435, 1829, 4117, 11331, 6027, 3660, 34683, 1829, 7435, 1829, 4117, 6225, 26895, 3660, 14739, 2655, 39894, 30544, 9154, 2423, 39184, 5670, 328, 701, 37495, 22653, 13412, 995, 4117, 4117, 14739, 23758, 3714, 43042, 4032, 2288, 5718, 104, 1829, 4032, 3224, 15730, 3714, 43042, 10874, 9957, 1829], "avg_logprob": -0.17216435061008842, "compression_ratio": 1.814070351758794, "no_speech_prob": 0.0, "words": [{"start": 4513.37, "end": 4514.35, "word": "أحياناً", "probability": 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"probability": 0.9634765625}, {"start": 4527.97, "end": 4528.57, "word": " حالة", "probability": 0.9944661458333334}, {"start": 4528.57, "end": 4529.77, "word": " وتيجيك", "probability": 0.85771484375}, {"start": 4529.77, "end": 4530.29, "word": " عيلة", "probability": 0.83349609375}, {"start": 4530.29, "end": 4530.65, "word": " أنت", "probability": 0.801025390625}, {"start": 4530.65, "end": 4531.29, "word": " بتكون", "probability": 0.953125}, {"start": 4531.29, "end": 4531.87, "word": " من", "probability": 0.92333984375}, {"start": 4531.87, "end": 4532.05, "word": " الـ", "probability": 0.831787109375}, {"start": 4532.05, "end": 4532.61, "word": " pedigree", "probability": 0.8106282552083334}, {"start": 4532.61, "end": 4534.29, "word": " يعني", "probability": 0.956787109375}, {"start": 4534.29, "end": 4535.13, "word": " شاكك", "probability": 0.9749755859375}, {"start": 4535.13, "end": 4535.67, "word": " أن", "probability": 0.7685546875}, {"start": 4535.67, "end": 4536.55, "word": " هذا", "probability": 0.63330078125}, {"start": 4536.55, "end": 4536.95, "word": " مرض", "probability": 0.9912109375}, {"start": 4536.95, "end": 4537.77, "word": " وراثي", "probability": 0.871875}, {"start": 4537.77, "end": 4538.69, "word": " وهذا", "probability": 0.7587076822916666}, {"start": 4538.69, "end": 4539.15, "word": " مرض", "probability": 0.9921875}, {"start": 4539.15, "end": 4540.11, "word": " جيني", "probability": 0.9586588541666666}], "temperature": 1.0}, {"id": 163, "seek": 456975, "start": 4540.55, "end": 4569.75, "text": "وإذا بالذات يعني بكون يعني هذا مرض وراثي وجيني بدي أفكر كيف بدي أجي أنا أعمل الأحسن أنه أعمل Whole Genome Sequencing بكون قريت لكل الناس إذا بالذات أنا بتكلم عن الأسرة اللي عندها المرض", "tokens": [2407, 28814, 15730, 20666, 8848, 9307, 37495, 22653, 4724, 30544, 37495, 22653, 23758, 3714, 43042, 4032, 2288, 5718, 104, 1829, 49610, 9957, 1829, 4724, 16254, 5551, 5172, 37983, 9122, 33911, 4724, 16254, 5551, 7435, 1829, 41850, 5551, 25957, 1211, 16247, 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"probability": 0.9921875}, {"start": 4567.39, "end": 4567.99, "word": " الأسرة", "probability": 0.9573567708333334}, {"start": 4567.99, "end": 4568.91, "word": " اللي", "probability": 0.9892578125}, {"start": 4568.91, "end": 4569.33, "word": " عندها", "probability": 0.9970703125}, {"start": 4569.33, "end": 4569.75, "word": " المرض", "probability": 0.99462890625}], "temperature": 1.0}, {"id": 164, "seek": 459914, "start": 4570.29, "end": 4599.15, "text": "وعندي أفراد مصابين وأفراد مش مصابين، ماشي؟ لما يكون عندي الـ Whole Genome Sequencing أني أقارن بينهم أحياناً يعني راح يكون الأمر يعني صعب جداً حتى على أقوى كمبيوتر أنه يسوي، ماشي؟ اللي بتكلموا عنه هنا", "tokens": [45367, 1863, 16254, 5551, 5172, 2288, 18513, 3714, 9381, 16758, 9957, 36725, 5172, 2288, 18513, 37893, 3714, 9381, 16758, 9957, 12399, 3714, 33599, 1829, 22807, 5296, 15042, 7251, 30544, 18871, 16254, 2423, 39184, 30336, 3632, 423, 46859, 13644, 14739, 1829, 5551, 4587, 9640, 1863, 49374, 16095, 5551, 5016, 1829, 7649, 995, 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" ماشي؟", "probability": 0.8375244140625}, {"start": 4576.21, "end": 4576.55, "word": " لما", "probability": 0.860595703125}, {"start": 4576.55, "end": 4576.93, "word": " يكون", "probability": 0.928955078125}, {"start": 4576.93, "end": 4577.25, "word": " عندي", "probability": 0.8349609375}, {"start": 4577.25, "end": 4577.41, "word": " الـ", "probability": 0.9130859375}, {"start": 4577.41, "end": 4577.63, "word": " Whole", "probability": 0.501953125}, {"start": 4577.63, "end": 4578.09, "word": " Genome", "probability": 0.7548828125}, {"start": 4578.09, "end": 4578.95, "word": " Sequencing", "probability": 0.985595703125}, {"start": 4578.95, "end": 4580.05, "word": " أني", "probability": 0.73828125}, {"start": 4580.05, "end": 4580.65, "word": " أقارن", "probability": 0.9925537109375}, {"start": 4580.65, "end": 4581.51, "word": " بينهم", "probability": 0.99267578125}, {"start": 4581.51, "end": 4583.21, "word": " أحياناً", "probability": 0.8767903645833334}, {"start": 4583.21, "end": 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5339.49, "end": 5339.59, "word": " و", "probability": 0.986328125}, {"start": 5339.59, "end": 5339.91, "word": " small", "probability": 0.75439453125}, {"start": 5339.91, "end": 5340.09, "word": " a", "probability": 0.7119140625}, {"start": 5340.09, "end": 5340.35, "word": " هيك", "probability": 0.783447265625}, {"start": 5340.35, "end": 5340.59, "word": " بدك", "probability": 0.9140625}, {"start": 5340.59, "end": 5341.15, "word": " تاخدهم", "probability": 0.8875732421875}, {"start": 5341.15, "end": 5341.69, "word": " و", "probability": 0.84228515625}, {"start": 5341.69, "end": 5341.79, "word": " ال", "probability": 0.79638671875}, {"start": 5341.79, "end": 5342.13, "word": " capital", "probability": 0.8681640625}, {"start": 5342.13, "end": 5342.59, "word": " B", "probability": 0.62255859375}, {"start": 5342.59, "end": 5342.97, "word": " و", "probability": 0.9794921875}, {"start": 5342.97, "end": 5343.45, "word": " small", "probability": 0.8984375}, {"start": 5343.45, "end": 5344.17, "word": " بيه", "probability": 0.76220703125}, {"start": 5344.17, "end": 5344.41, "word": " مش", "probability": 0.2381591796875}, {"start": 5344.41, "end": 5344.83, "word": " small", "probability": 0.94677734375}, {"start": 5344.83, "end": 5345.09, "word": " بيه", "probability": 0.9104817708333334}, {"start": 5345.09, "end": 5345.33, "word": " فيه", "probability": 0.70068359375}, {"start": 5345.33, "end": 5345.89, "word": " o", "probability": 0.48974609375}, {"start": 5345.89, "end": 5347.21, "word": " ماشي", "probability": 0.8318684895833334}, {"start": 5347.21, "end": 5348.85, "word": " بدك", "probability": 0.7509765625}, {"start": 5348.85, "end": 5351.13, "word": " تجربها", "probability": 0.943603515625}, {"start": 5351.13, "end": 5352.09, "word": " شوفها", "probability": 0.7906087239583334}, {"start": 5352.09, "end": 5352.85, "word": " ماشي", "probability": 0.7854817708333334}, {"start": 5352.85, "end": 5353.49, "word": " الله", "probability": 0.93359375}, {"start": 5353.49, "end": 5353.91, "word": " يعطيكم", "probability": 0.9197998046875}, {"start": 5353.91, "end": 5354.53, "word": " العافية", "probability": 0.9459635416666666}, {"start": 5354.53, "end": 5355.53, "word": " يعطيك", "probability": 0.930419921875}, {"start": 5355.53, "end": 5355.71, "word": " ألف", "probability": 0.701904296875}, {"start": 5355.71, "end": 5355.95, "word": " عافية", "probability": 0.9689127604166666}, {"start": 5355.95, "end": 5356.31, "word": " دكتور", "probability": 0.9205322265625}], "temperature": 1.0}, {"id": 193, "seek": 538636, "start": 5356.7, "end": 5386.36, "text": "الله يرضى عليك جمال بدك الأسئلة على ال word صح؟ وكل واحدة عليها الإجابة ان شاء الله رب العالمين لسه شغال عليها و بس أخلص و أبعتلك إياها تمام يا عزيزي يا عزيزي الله يسهل الله يسهل الله يسهل الله يسهل الله يسهل الله يسهل الله يسهل الله يسهل الله يسهل الله يسهل الله يسهل الله يسهل الله يسهل الله يسهل الله يسهل", "tokens": [6027, 43761, 7251, 43042, 7578, 25894, 4117, 10874, 2304, 6027, 47525, 4117, 16247, 3794, 19986, 37977, 15844, 2423, 1349, 20328, 5016, 22807, 4032, 28820, 36764, 24401, 3660, 25894, 11296, 33688, 7435, 16758, 3660, 16472, 13412, 16606, 21984, 12602, 3555, 18863, 45340, 9957, 5296, 3794, 3224, 13412, 17082, 6027, 25894, 11296, 4032, 4724, 3794, 5551, 9778, 1211, 9381, 4032, 5551, 3555, 34268, 23275, 11933, 25528, 11296, 46811, 10943, 35186, 6225, 11622, 1829, 11622, 1829, 35186, 6225, 11622, 1829, 11622, 1829, 21984, 7251, 3794, 3224, 1211, 21984, 7251, 3794, 3224, 1211, 21984, 7251, 3794, 3224, 1211, 21984, 7251, 3794, 3224, 1211, 21984, 7251, 3794, 3224, 1211, 21984, 7251, 3794, 3224, 1211, 21984, 7251, 3794, 3224, 1211, 21984, 7251, 3794, 3224, 1211, 21984, 7251, 3794, 3224, 1211, 21984, 7251, 3794, 3224, 1211, 21984, 7251, 3794, 3224, 1211, 21984, 7251, 3794, 3224, 1211, 21984, 7251, 3794, 3224, 1211, 21984, 7251, 3794, 3224, 1211, 21984, 7251, 3794, 3224, 1211], "avg_logprob": -0.21693548002550678, "compression_ratio": 3.0726256983240225, "no_speech_prob": 4.947185516357422e-06, "words": [{"start": 5356.7, "end": 5357.02, "word": "الله", "probability": 0.824951171875}, {"start": 5357.02, "end": 5357.34, "word": " يرضى", "probability": 0.9558919270833334}, {"start": 5357.34, "end": 5357.72, "word": " عليك", "probability": 0.95654296875}, {"start": 5357.72, "end": 5358.62, "word": " جمال", "probability": 0.9093424479166666}, {"start": 5358.62, "end": 5359.38, "word": " بدك", "probability": 0.6649169921875}, {"start": 5359.38, "end": 5360.02, "word": " الأسئلة", "probability": 0.94482421875}, {"start": 5360.02, "end": 5361.06, "word": " على", "probability": 0.57421875}, {"start": 5361.06, "end": 5361.3, "word": " ال", "probability": 0.9208984375}, {"start": 5361.3, "end": 5361.56, "word": " word", "probability": 0.8505859375}, {"start": 5361.56, "end": 5362.42, "word": " صح؟", "probability": 0.8644205729166666}, {"start": 5362.42, "end": 5362.7, "word": " وكل", "probability": 0.773193359375}, {"start": 5362.7, "end": 5363.02, "word": " واحدة", "probability": 0.7649739583333334}, {"start": 5363.02, "end": 5363.3, "word": " عليها", "probability": 0.971435546875}, {"start": 5363.3, "end": 5364.3, "word": " الإجابة", "probability": 0.9825439453125}, {"start": 5364.3, "end": 5364.56, "word": " ان", "probability": 0.367919921875}, {"start": 5364.56, "end": 5364.82, "word": " شاء", "probability": 0.973876953125}, {"start": 5364.82, "end": 5365.0, "word": " الله", "probability": 0.93505859375}, {"start": 5365.0, "end": 5365.26, "word": " رب", "probability": 0.9609375}, {"start": 5365.26, "end": 5366.08, "word": " العالمين", "probability": 0.9934895833333334}, {"start": 5366.08, "end": 5366.44, "word": " لسه", "probability": 0.9656575520833334}, {"start": 5366.44, "end": 5366.94, "word": " شغال", "probability": 0.9690755208333334}, {"start": 5366.94, "end": 5367.38, "word": " عليها", "probability": 0.993408203125}, {"start": 5367.38, "end": 5367.72, "word": " و", "probability": 0.8037109375}, {"start": 5367.72, "end": 5367.94, "word": " بس", "probability": 0.934814453125}, {"start": 5367.94, "end": 5368.32, "word": " أخلص", "probability": 0.84912109375}, {"start": 5368.32, "end": 5368.44, "word": " و", "probability": 0.44091796875}, {"start": 5368.44, "end": 5368.84, "word": " أبعتلك", "probability": 0.755126953125}, {"start": 5368.84, "end": 5369.48, "word": " إياها", "probability": 0.8583984375}, {"start": 5369.48, "end": 5370.24, "word": " تمام", "probability": 0.874755859375}, {"start": 5370.24, "end": 5370.48, "word": " يا", "probability": 0.126220703125}, {"start": 5370.48, "end": 5370.48, "word": " عزيزي", "probability": 0.85078125}, {"start": 5370.48, "end": 5370.7, "word": " يا", "probability": 0.072998046875}, {"start": 5370.7, "end": 5370.78, "word": " عزيزي", "probability": 0.888818359375}, {"start": 5370.78, "end": 5371.18, "word": " الله", "probability": 0.1270751953125}, {"start": 5371.18, "end": 5381.64, "word": " يسهل", "probability": 0.70611572265625}, {"start": 5381.64, "end": 5382.06, "word": " الله", "probability": 0.58203125}, {"start": 5382.06, "end": 5382.32, "word": " يسهل", "probability": 0.99658203125}, {"start": 5382.32, "end": 5382.58, "word": " الله", "probability": 0.2025146484375}, {"start": 5382.58, "end": 5383.18, "word": " يسهل", "probability": 0.994384765625}, {"start": 5383.18, "end": 5383.36, "word": " الله", "probability": 0.443359375}, {"start": 5383.36, "end": 5383.84, "word": " يسهل", "probability": 0.98876953125}, {"start": 5383.84, "end": 5383.88, "word": " الله", "probability": 0.247802734375}, {"start": 5383.88, "end": 5383.88, "word": " يسهل", "probability": 0.974609375}, {"start": 5383.88, "end": 5384.08, "word": " الله", "probability": 0.29345703125}, {"start": 5384.08, "end": 5384.54, "word": " يسهل", "probability": 0.9766845703125}, {"start": 5384.54, "end": 5384.54, "word": " الله", "probability": 0.50341796875}, {"start": 5384.54, "end": 5385.62, "word": " يسهل", "probability": 0.98583984375}, {"start": 5385.62, "end": 5385.8, "word": " الله", "probability": 0.65478515625}, {"start": 5385.8, "end": 5386.36, "word": " يسهل", "probability": 0.9915771484375}, {"start": 5386.36, "end": 5386.36, "word": " الله", "probability": 0.73291015625}, {"start": 5386.36, "end": 5386.36, "word": " يسهل", "probability": 0.9940185546875}, {"start": 5386.36, "end": 5386.36, "word": " الله", "probability": 0.779296875}, {"start": 5386.36, "end": 5386.36, "word": " يسهل", "probability": 0.9951171875}, {"start": 5386.36, "end": 5386.36, "word": " الله", "probability": 0.80078125}, {"start": 5386.36, "end": 5386.36, "word": " يسهل", "probability": 0.99560546875}, {"start": 5386.36, "end": 5386.36, "word": " الله", "probability": 0.8134765625}, {"start": 5386.36, "end": 5386.36, "word": " يسهل", "probability": 0.99560546875}, {"start": 5386.36, "end": 5386.36, "word": " الله", "probability": 0.81982421875}, {"start": 5386.36, "end": 5386.36, "word": " يسهل", "probability": 0.99560546875}, {"start": 5386.36, "end": 5386.36, "word": " الله", "probability": 0.826171875}, {"start": 5386.36, "end": 5386.36, "word": " يسهل", "probability": 0.99560546875}, {"start": 5386.36, "end": 5386.36, "word": " الله", "probability": 0.82568359375}, {"start": 5386.36, "end": 5386.36, "word": " يسهل", "probability": 0.995361328125}], "temperature": 1.0}, {"id": 194, "seek": 538708, "start": 5386.48, "end": 5387.08, "text": "العزيزي", "tokens": [6027, 3615, 11622, 1829, 11622, 1829], "avg_logprob": -0.9285714626312256, "compression_ratio": 0.7, "no_speech_prob": 0.002292633056640625, "words": [{"start": 5386.48, "end": 5387.08, "word": "العزيزي", "probability": 0.5271402994791666}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 5388.0511875, "duration_after_vad": 5282.765343750018}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/ofPBC5zCpyc_raw.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/ofPBC5zCpyc_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..31150682a5174aa264abaf98b86e9423759b82c6
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/ofPBC5zCpyc_raw.srt
@@ -0,0 +1,3516 @@
+1
+00:00:00,000 --> 00:00:03,860
+affected مش كامل، mild يعني مش صحيح زي اللي بيكون
+
+2
+00:00:03,860 --> 00:00:16,140
+اللي هو homozygous شوف، يعني المبدأ لموضوع إنه
+
+3
+00:00:16,140 --> 00:00:22,840
+autosomal dominant ماشي المبدأ إنه هو اللي بيظهر
+
+4
+00:00:22,840 --> 00:00:31,100
+بس على شرط إن الصفر هذه تعتمد فقطعلى جين واحد
+
+5
+00:00:31,100 --> 00:00:38,180
+أحيانًا الأمور أعقد من هيك واللي هو بنبدأ ندخل
+
+6
+00:00:38,180 --> 00:00:42,920
+أكتر في الـ Polygenic اللي كنا نتكلم عنه قبل شوية
+
+7
+00:00:42,920 --> 00:00:47,940
+الأسبوع، مش المحاضرة اللي فاتت، اللي قبلها لما
+
+8
+00:00:47,940 --> 00:00:55,700
+نكون أكتر من جين وEpigenetic Control وكده وهيك ففي
+
+9
+00:00:55,700 --> 00:01:01,680
+أحيانًا الـ Dominanceبيرتبط بـ Sticks حكينا مثال
+
+10
+00:01:01,680 --> 00:01:07,560
+الصلع الصلع في جين معين في الذكور dominant في الـ
+
+11
+00:01:07,560 --> 00:01:11,600
+females recessive يعني مش دايماً لما نقول dominant
+
+12
+00:01:11,600 --> 00:01:16,060
+يعني دايماً dominant وفي كل الحالات dominant وكذا
+
+13
+00:01:16,060 --> 00:01:20,580
+حتى لو إنه على الـ autosomal genes يعني ما هو مش
+
+14
+00:01:20,580 --> 00:01:24,640
+على الـ sex linked genes هدولة بس مرتبط بالجنة
+
+15
+00:01:24,640 --> 00:01:30,920
+فالآن في صفتينإضافيات على كلمة الـ Dominant بدت
+
+16
+00:01:30,920 --> 00:01:36,600
+تفهم إنه أحيانًا Dominance بيسموه مش كامل يعني
+
+17
+00:01:36,600 --> 00:01:45,280
+صحيح هو موجود بس مش 100% يعني مش هيظهر في 100% من
+
+18
+00:01:45,280 --> 00:01:51,400
+الناس أو 100% من الدرجة الشدة يعني ممكن يكون مثلًا
+
+19
+00:01:51,400 --> 00:01:55,780
+واحد اللي عنده الأتزامة الـ Dominant إذا فرضنا صفة
+
+20
+00:01:55,780 --> 00:02:01,670
+معينةبتلاقيها طارت 100% بينما ممكن و الـ
+
+21
+00:02:01,670 --> 00:02:05,990
+heterozygous بتتوقع أنه يكون 50% مثلا عنده مثلًا
+
+22
+00:02:05,990 --> 00:02:11,630
+نفترض إشي معين فاللي بتلاقيه autosomal dominance
+
+23
+00:02:11,630 --> 00:02:18,590
+بتلاقي incomplete penetrance يعني ما بيظهر بشكل
+
+24
+00:02:18,590 --> 00:02:25,070
+كامل يعني ممكن ما يظهرش و في العكس ممكن اتغير
+
+25
+00:02:25,070 --> 00:02:31,270
+النسباللي تشوفه إنه لو autosomal dominance و
+
+26
+00:02:31,270 --> 00:02:38,390
+lethal يعني مرض شديد كتير كتير كتير بحيث إنه ما في
+
+27
+00:02:38,390 --> 00:02:43,770
+إنسان يولد فيه بعيش سواء في فترة الـ embryonic
+
+28
+00:02:43,770 --> 00:02:48,910
+period أو الجن أو يعني فيتغير النسب اللي بتلاقيها
+
+29
+00:02:48,910 --> 00:02:53,180
+فاهم عليك كده؟ففيه Lethal وDominant في بعضها
+
+30
+00:02:53,180 --> 00:02:57,400
+Lethal وبعضها Incomplete Venetrance والأصل الـ
+
+31
+00:02:57,400 --> 00:03:04,440
+Classical اللي أنت بهيك كمفهوم عام بيقول إنه الـ
+
+32
+00:03:04,440 --> 00:03:10,560
+Trait هادي أو الصفة هادي بهذا الشكل هي الـ
+
+33
+00:03:10,560 --> 00:03:14,880
+Dominant فمعناه كذا، فهذا المقصود بمثل هيك أشياء
+
+34
+00:03:14,880 --> 00:03:21,240
+بفرجوكي إياها الآن بدك ترجع تفهم مرة ثانية شغلةحتى
+
+35
+00:03:21,240 --> 00:03:27,080
+لما اتكلمنا بنأول على موضوع اللي
+
+36
+00:03:27,080 --> 00:03:35,540
+هو اللي بيسموه الـ Reference Sequence أنت تتكلم عن
+
+37
+00:03:35,540 --> 00:03:38,840
+أحيانًا دراسة معينة عملوها في لحظة معينة على
+
+38
+00:03:38,840 --> 00:03:45,740
+مجموعة معينة على عيلة معينة، كده فضمن هذه المعطيات
+
+39
+00:03:45,740 --> 00:03:52,250
+اللي هي هذه العيلةكان الظاهرة
+
+40
+00:03:52,250 --> 00:03:55,970
+الموجودة واللي بحثناها بهذا الشكل فبنستنتجها
+
+41
+00:03:55,970 --> 00:04:00,870
+والاستنتاج فاهم عليك كده؟ فانت كلمة «dominant» لا
+
+42
+00:04:00,870 --> 00:04:06,030
+تعني dominant مطلق هيك نفس المستوى لكل الجينات وكل
+
+43
+00:04:06,030 --> 00:04:12,330
+العائلات وكل الناس، لأ، بتلاقي الأمر، إيش اسمه،
+
+44
+00:04:12,330 --> 00:04:19,950
+فيه تفاوضفي أسئلة أخرى إن شاء الله أجاوب عليها بس
+
+45
+00:04:19,950 --> 00:04:26,930
+خليني أسأل أسئلة بقى نعم أسأل سؤال تاني بس أتفضل،
+
+46
+00:04:26,930 --> 00:04:28,190
+أتفضل، أتفضل، أتفضل، أتفضل، أتفضل، أتفضل، أتفضل،
+
+47
+00:04:28,190 --> 00:04:31,090
+أتفضل، أتفضل، أتفضل، أتفضل، أتفضل، أتفضل، أتفضل،
+
+48
+00:04:31,090 --> 00:04:31,110
+أتفضل، أتفضل، أتفضل، أتفضل، أتفضل، أتفضل، أتفضل،
+
+49
+00:04:31,110 --> 00:04:39,150
+أتفضل، أتفضل، أتفضل، أتفضل، أتفضل، أتفضل، أتفضل، أ
+
+50
+00:04:40,730 --> 00:04:44,670
+وهذا بيكون complete، اللي هو مثلا نفترض إنه دي دي
+
+51
+00:04:44,670 --> 00:04:50,610
+كcapital والناس ال male اللي مش maintain و ال
+
+52
+00:04:50,610 --> 00:04:56,790
+female برضه هادة نفترض إنها Tigers، لإنه ممكن تكون
+
+53
+00:04:56,790 --> 00:05:00,630
+دي قدر المسموعة ‏-أنا أتبقى من ال picture ‏-صحيح؟
+
+54
+00:05:00,630 --> 00:05:05,730
+‏-اشو، اسمع علي، بس كافي عن الصحيحة
+
+55
+00:05:09,080 --> 00:05:14,240
+الـ «إيه» أنا مش شايفها، شايف اللي حاطف عليها
+
+56
+00:05:14,240 --> 00:05:21,520
+«إيه» وين 100% بيكون، بس الـ «بديجري» اللي تبع
+
+57
+00:05:21,520 --> 00:05:26,900
+العيلة هذه «أكندروبلازيا»، «incompletely dominant
+
+58
+00:05:26,900 --> 00:05:31,400
+trait»، بكون لما أنا شوف انت عنيه؟ أنا و«جزوف»
+
+59
+00:05:31,400 --> 00:05:36,700
+بتتكلم عنه؟ عن
+
+60
+00:05:36,700 --> 00:05:48,120
+صوت بيه؟B ما لها؟ ماشي الـ الـ الان شو المشكلة هنا
+
+61
+00:05:48,120 --> 00:05:55,180
+المشكلة إنه إذا هذا الـ dominant و أثنين أشخاص
+
+62
+00:05:55,180 --> 00:06:06,600
+عندهم أكندربلازيا، ماشي؟ ماشي الحال معايا؟ إذا كان
+
+63
+00:06:09,080 --> 00:06:17,200
+طيب خلّيني ا share screen خلّيني
+
+64
+00:06:17,200 --> 00:06:20,440
+ا .. بس عشان لأنهم بيسألوا شو الصورة اللي بنحكي
+
+65
+00:06:20,440 --> 00:06:28,280
+عنها بحكي لصورة زي هيك ال .. ده .. الأعناء هي عالي
+
+66
+00:06:28,280 --> 00:06:42,480
+ودول اثنين يعني ال .. اثنين همزلمة ومرة عندهم
+
+67
+00:06:42,480 --> 00:06:47,220
+أكندربلازيا وكانت أنا فحصتهم ولقيتهم dominant
+
+68
+00:06:47,220 --> 00:06:55,260
+ولقيت two copies الأصل لو فيه two copies ماشي يعني
+
+69
+00:06:55,260 --> 00:07:00,260
+لو بقدر واحد يحسبها لو واحد بس شخص مصعب الاحتمالي
+
+70
+00:07:00,260 --> 00:07:04,660
+المفروض تكون نص بس إذا اثنين مصعبين لازم تكون أكتر
+
+71
+00:07:04,660 --> 00:07:12,100
+واحتمالواحد منهم كان يعني يعني ده اثنين اتزوجوا
+
+72
+00:07:12,100 --> 00:07:21,820
+هيك ليش الفرد هذا البنت هذه طلعت طبيعية ماشي فالآن
+
+73
+00:07:21,820 --> 00:07:29,400
+يعني أنا اللي بتحكيلكيها لصور زي هيك بدك تدخل يعني
+
+74
+00:07:29,400 --> 00:07:34,260
+صعب أكتر أشرحلك يعني ده المبدأ أنت فاهمه من ناحية
+
+75
+00:07:34,850 --> 00:07:37,790
+ماذا يعني Dominant؟ ماذا يعني Resistive؟ ماذا يعني
+
+76
+00:07:37,790 --> 00:07:41,450
+Autosomal؟ وماذا يعني الـ X-Links؟ الـ Patterns
+
+77
+00:07:41,450 --> 00:07:45,630
+للـ Inheritance، إذا أنت فاهمها الآن هنا إثنين
+
+78
+00:07:45,630 --> 00:07:50,430
+مصابين، كيف يطلع لهم ابن طبيعي؟ هذا يجب أن يكون
+
+79
+00:07:50,430 --> 00:07:54,470
+الواحد يتكلم على إنه فيه Incomplete Dominance
+
+80
+00:07:54,470 --> 00:07:58,490
+ماشي، أو Semi-dominant trait، يعني هذا كنوع من
+
+81
+00:07:58,490 --> 00:08:03,830
+التفسير ممكن إنهم إثنين هم Heterozygous، وهذا طلع
+
+82
+00:08:04,280 --> 00:08:12,820
+من الـ Recessive trait شو اسمه اللي هنا Normal
+
+83
+00:08:12,820 --> 00:08:17,740
+طلعت واحدة منهم يعني اللي هي الرُبع لما نكون
+
+84
+00:08:17,740 --> 00:08:21,700
+Recessive trait بس هذه الـ Recessive trait هنا
+
+85
+00:08:21,700 --> 00:08:27,020
+بمعنى إن الـ Disease هو dominant فالـ Normal هو
+
+86
+00:08:27,020 --> 00:08:32,300
+الـ Recessive فبيّن إشي أو إنه يمكن هذا شخص عنده
+
+87
+00:08:32,300 --> 00:08:36,850
+الـ Geneبس مش مبين لأنه مش Completely Dominant
+
+88
+00:08:36,850 --> 00:08:41,370
+Incompletely Dominant يعني أو Semi-dominant فاهم
+
+89
+00:08:41,370 --> 00:08:48,290
+عليك كده؟ فالآن يعني ما بتقدر يعني خد الفكرة من
+
+90
+00:08:48,290 --> 00:08:53,690
+الـ Pedigree الـ Pedigree العيلة هدولة عيلتين
+
+91
+00:08:53,690 --> 00:09:01,730
+مختلفتين صار فيهم mutation لموقع
+
+92
+00:09:01,730 --> 00:09:08,360
+معينسوّت هذا المرض شخصين عندما دول المرض اتزوجوا
+
+93
+00:09:08,360 --> 00:09:14,220
+الأصل أنه كل ولادهم بناتهم يكونوا يعني مش كلهم بدل
+
+94
+00:09:14,220 --> 00:09:19,220
+واحد 75% على الأقل يطلعوا إذا أثنانهم بيكونوا
+
+95
+00:09:19,220 --> 00:09:29,670
+heterozygous بيطلعوا affected وده أنت درستعلى
+
+96
+00:09:29,670 --> 00:09:36,610
+موضوع شو اسمه درست على موضوع المستوى الجيني بتلاقي
+
+97
+00:09:36,610 --> 00:09:39,970
+أحيانًا ممكن الجين المصاب عند هذا الشخص بصي شيء
+
+98
+00:09:39,970 --> 00:09:46,730
+مبين عليه هذه النقطة – صحيح – ماشي نكمل – خليني بس
+
+99
+00:09:46,730 --> 00:09:50,150
+أسأل الـ type عندها و نشوف صح و لا خطأ – إيش هو؟ –
+
+100
+00:09:50,150 --> 00:09:53,330
+لإن أنا أسفة تقريبًا مصدش، بدي أكتب الـgenotype و
+
+101
+00:09:53,330 --> 00:09:56,250
+أنت شوف صح و لا خطأ، تقريبًا سؤالي مصدش – أنا
+
+102
+00:09:56,250 --> 00:10:05,070
+الصورة هنا الـM شايفةالـ «إيه» مش شايفة «هل دي
+
+103
+00:10:05,070 --> 00:10:11,270
+كمتل» «هل دي كمتل» «هل
+
+104
+00:10:11,270 --> 00:10:20,390
+دي كمتل» «هل دي كمتل» «هل دي كمتل» «هل دي كمتل»
+
+105
+00:10:20,390 --> 00:10:21,490
+«هل دي كمتل» «هل دي كمتل» «هل دي كمتل» «هل دي
+
+106
+00:10:21,490 --> 00:10:23,150
+كمتل» «هل دي كمتل» «هل دي كمتل» «هل دي كمتل» «هل
+
+107
+00:10:23,150 --> 00:10:24,790
+دي كمتل» «هل دي كمتل» «هل دي كمتل» «هل دي كمتل»
+
+108
+00:10:24,790 --> 00:10:27,370
+«هل دي كمتل» «هل دي كمتل» «هل دي كمتل» «هل دي
+
+109
+00:10:27,370 --> 00:10:29,410
+كمتل» «ه
+
+110
+00:10:32,880 --> 00:10:36,420
+اللي بتوفي هاد، مكتوب في السؤال «dominant
+
+111
+00:10:36,420 --> 00:10:40,940
+-complete»، فمعدل ولادة مباشرة، إنما الليل اللي مش
+
+112
+00:10:40,940 --> 00:10:43,860
+توفي هاد، هذا «incomplete-dominant»، فبقى عايش حتى
+
+113
+00:10:43,860 --> 00:10:48,500
+الآن. بفهم من هيك إن الأم هدولة بيكونوا
+
+114
+00:10:48,500 --> 00:10:51,880
+«incomplete-dominant»، والدليل إنه أعطوا بنت خانة
+
+115
+00:10:51,880 --> 00:10:55,200
+مش مصالبة من الأساس، فمتوقع إن هد بيكون مثلًا
+
+116
+00:10:55,200 --> 00:11:00,000
+«decapital»، «de-small»،«welcome to this world» و
+
+117
+00:11:00,000 --> 00:11:03,700
+«this world» و «this world» منهم اللي هو الصفة
+
+118
+00:11:03,700 --> 00:11:07,860
+المفترضة صحيح، ما هي اللي كنت حاولتها صحيح؟ آه،
+
+119
+00:11:07,860 --> 00:11:12,220
+صحيح أنا بدي أسأل الفكرة هذه، إنه الأب، الميل،
+
+120
+00:11:12,220 --> 00:11:18,680
+والأبوين، بالنسبة لهذا، الأصل تبعهم فوق، مفيش فيه
+
+121
+00:11:18,680 --> 00:11:22,320
+إصابات، يعني هم مفيش إصابة بالمرة، كيف هروصلتهم
+
+122
+00:11:22,320 --> 00:11:27,700
+الإصابة، خاصة الطلين؟ آه، آهوهذه إذا كانت عندهم
+
+123
+00:11:27,700 --> 00:11:31,200
+الصفحة هان فطبيعي لازم تكون ظاهرة عند أحد الأبوين
+
+124
+00:11:31,200 --> 00:11:39,320
+فورا وبالتالي شو ال conclusion؟ إن هدول بشر صارت
+
+125
+00:11:39,320 --> 00:11:44,720
+عندهم ال mutation هي بدأت in بضبط أنا بس ال
+
+126
+00:11:44,720 --> 00:11:48,520
+mutation طلعت عند الأب و الأم فمان مع بعض صحيح؟
+
+127
+00:11:48,520 --> 00:11:52,740
+إيش هو؟ ال mutation طلعت عند الأب و الأم مع بعض
+
+128
+00:11:52,740 --> 00:11:58,280
+اللي هو الجيل الثاني أه أه أههو هنا يعني عيلتين
+
+129
+00:11:58,280 --> 00:12:03,380
+أكندرو بلايزيا بتعرف صورتهم كيف حجم جسمهم طبيعي بس
+
+130
+00:12:03,380 --> 00:12:08,220
+أطرافهم قصيرة جدا فبكونوا بالـ Circus بكونوا
+
+131
+00:12:08,220 --> 00:12:14,040
+بالأفلام بتشوفهم أحيانا كذا ولا هيك لو من عيلتين
+
+132
+00:12:14,040 --> 00:12:19,720
+مختلفتين شخصين بهذه الصفات حبوا بعض و اتجوزوا بعض
+
+133
+00:12:19,720 --> 00:12:27,320
+بتصير فاهم عليك؟ ألا لما يكونوا زي هيتوقعنا إنه
+
+134
+00:12:27,320 --> 00:12:34,900
+الـ 75% من الـ من الأطفال
+
+135
+00:12:34,900 --> 00:12:39,860
+اللي بيطلعوا راح يكونوا برضه أكندربلازيا ماشي،
+
+136
+00:12:39,860 --> 00:12:43,280
+واللي
+
+137
+00:12:43,280 --> 00:12:51,980
+عنده 25% اللي هي الـ 25% اللي هي الـ Double اللي
+
+138
+00:12:51,980 --> 00:12:57,180
+بيكون homozygous، dominantيمكن يكون lethal فاهم
+
+139
+00:12:57,180 --> 00:13:05,000
+عليك كيف؟ فبالتالي بيعيشش هذا مفتوح دكتور أه بس في
+
+140
+00:13:05,000 --> 00:13:08,820
+مفتوح ثاني برضه مش في هذه الصورة هلجيتها في جزيرة
+
+141
+00:13:08,820 --> 00:13:16,480
+ال X inactivation عند الفميل؟ نعم ممكن هو يعمل X
+
+142
+00:13:16,480 --> 00:13:18,900
+inactivation لبعض الجنة مش كله يعمل X inactivation
+
+143
+00:13:18,900 --> 00:13:25,270
+إيه شو؟الـ Chromosome X لما يحصل Deactivation عند
+
+144
+00:13:25,270 --> 00:13:28,370
+الثمن آه، مش كله بيحصل Deactivation بيحصل
+
+145
+00:13:28,370 --> 00:13:33,530
+Expiration لبعض جينات المنسية لأ، المقصود في الـ
+
+146
+00:13:33,530 --> 00:13:40,550
+Random Deactivation للجينات
+
+147
+00:13:40,550 --> 00:13:45,530
+اللي احنا بنحكي عنه الـ Ionization بتلاقي الجين
+
+148
+00:13:45,530 --> 00:13:52,540
+كامل مش شغال، مش مفروضكيف شكله على الميكروسكوب لما
+
+149
+00:13:52,540 --> 00:13:58,520
+تتطلع عليه لما قعدنا نفحص اللي بيكون بار بيديز
+
+150
+00:13:58,520 --> 00:14:05,220
+ماشي في الـ meiosis و الـ mitosis أو الـ mitosis
+
+151
+00:14:05,220 --> 00:14:12,220
+في الـ meiosis في الفيميل بيكون بيسموه في إيه إشي
+
+152
+00:14:12,220 --> 00:14:17,340
+بيسموه الـ polar body هذا بيكون خلية كاملة هي
+
+153
+00:14:17,340 --> 00:14:23,190
+نفسها بتكون زي النقطةأما بالنسبة للـ X-Chromosome
+
+154
+00:14:23,190 --> 00:14:29,270
+بتلاقي بشكل عشوائي مرة هاد ومرة هاد، ما هو ما فيه
+
+155
+00:14:29,270 --> 00:14:35,850
+اتنين بالـ Female واحد بس شغال والتاني مسكر فاهم
+
+156
+00:14:35,850 --> 00:14:41,670
+عليك كيف؟ فبنشوفه لما تعمل Bar Body Study بتشوف
+
+157
+00:14:41,670 --> 00:14:46,260
+النقطة تبع الـ X-Chromosome وبكون Inactive كلهمش
+
+158
+00:14:46,260 --> 00:14:49,920
+بعض الجينات شغالة من هذا وبعض الجينات شغالة من هذا
+
+159
+00:14:49,920 --> 00:14:53,320
+واضح؟
+
+160
+00:14:53,320 --> 00:15:01,960
+طيب، في أسئلة كمان أنا بقترح اكتبوا الأسئلة
+
+161
+00:15:01,960 --> 00:15:07,540
+وخلّينا سواء بأول المحاضرة أو بآخر المحاضرة نحطهم
+
+162
+00:15:07,540 --> 00:15:17,270
+كلهم وش اسمه؟ ويعني نشوف، ماشي؟دكتور في سؤال من
+
+163
+00:15:17,270 --> 00:15:23,030
+دكتور علمازي قول شو الفرق بين ال semi-dominant و
+
+164
+00:15:23,030 --> 00:15:27,990
+ال pure-dominant و ال co-dominant ال co-dominant
+
+165
+00:15:27,990 --> 00:15:34,990
+لما ال two traits بتكون زي بعض رأس برأس اتنين هم
+
+166
+00:15:34,990 --> 00:15:41,950
+بتظهروا يعني زي ال ABO system ال A و ال B على بعض
+
+167
+00:15:41,950 --> 00:15:47,490
+co-dominant يعنيلو واحد عنده A و B، إثنين بدهم
+
+168
+00:15:47,490 --> 00:15:52,410
+يظهروا تبعتهم، فاهم عليك كيف؟ فهذه الإسمة Co
+
+169
+00:15:52,410 --> 00:15:59,910
+-dominant أما الـ A و الـ O أو الـ B و الـ O الـ A
+
+170
+00:15:59,910 --> 00:16:04,810
+و الـ B هم الـ dominant على الـ O يعني الـ O مافيش
+
+171
+00:16:04,810 --> 00:16:11,710
+منه إشي، مابيبينش إشي فيه فبالتالي بكون بس الـ A
+
+172
+00:16:11,710 --> 00:16:20,670
+أو الـ B هو اللي موجودماشي، فشو اسمه؟
+
+173
+00:16:20,670 --> 00:16:24,330
+يعني
+
+174
+00:16:24,330 --> 00:16:32,930
+شو اسمه؟ الأن الموضوع الثالث أنه حتى لو dominant
+
+175
+00:16:32,930 --> 00:16:40,950
+أحياناً درجاته بتختلف وإذا هنا يعني درجاته بتختلف
+
+176
+00:16:41,460 --> 00:16:47,140
+بصير الواحد كأنه بدي يدخل على مواضيع الـ Polygenic
+
+177
+00:16:47,140 --> 00:16:52,140
+Disorders يعني يمكن يكون الصفة هذه أكثر من جين
+
+178
+00:16:52,140 --> 00:16:56,180
+بتحكم فيها مش جين واحد اللي أنا بدرسه فاهم عليك
+
+179
+00:16:56,180 --> 00:17:02,780
+كيف؟ فكلمة Incomplete Dominance أو Lethal أو أنواع
+
+180
+00:17:02,780 --> 00:17:11,410
+ثانية بتتكلم على يعني variationتغييرها على يعني في
+
+181
+00:17:11,410 --> 00:17:17,390
+أن بعض الجينات ما بتكون 100% Classical هذا يُعطى
+
+182
+00:17:17,390 --> 00:17:22,670
+كنوع من التفسير لظاهر أحنا بنشوفها فاهم عليك كيف؟
+
+183
+00:17:22,670 --> 00:17:28,390
+بحيث أن أحيانًا بكون الـdominance مش كامل أدل إن
+
+184
+00:17:28,390 --> 00:17:35,070
+واحد يصله في أسئلة كمان؟ خلّينا نمشي في المحاضرة
+
+185
+00:17:36,980 --> 00:17:42,480
+وكل الأسئلة يعني إذا بنحطها على الـ Group بتكون
+
+186
+00:17:42,480 --> 00:17:50,880
+بشكل أوضح بالذات كـ Concept إذا فيها مشكلة يعني
+
+187
+00:17:50,880 --> 00:17:56,160
+بنتكلم عنها البداية
+
+188
+00:17:56,160 --> 00:18:03,100
+المحاضرة اليوم بتعطيكم homework خدوه وش اسمه يعني
+
+189
+00:18:03,100 --> 00:18:10,990
+فكروا فيهوالأسبوع الجاي بنحله وبنشوف شو الـ الـ
+
+190
+00:18:10,990 --> 00:18:21,490
+نتاج سبحته الملخص المحاضرة اللي فاتت أنه الـ الـ
+
+191
+00:18:21,490 --> 00:18:26,990
+في حالة الـ steady state في حالة أنه مافيش هجرات
+
+192
+00:18:26,990 --> 00:18:33,640
+مافيش mutations مافيش يعنيسيلكشن في الزواج لمجموعة
+
+193
+00:18:33,640 --> 00:18:39,560
+معينة دون أن عن الأخرى الـ Frequency لـ الـ Two
+
+194
+00:18:39,560 --> 00:18:45,940
+Alleles اللي بدنا نشتغل عليهم بيكون الـ P و الـ Q
+
+195
+00:18:45,940 --> 00:18:53,960
+و P و Q مجموعهم يساوي واحد اللي هي نسبة اللي
+
+196
+00:18:53,960 --> 00:18:57,740
+موجودة في الـ Population والمثال اللي حطوه الـ
+
+197
+00:18:57,740 --> 00:19:08,050
+CCR5الـ Mutated CCR5 Receptor Mutations اللي حكينا
+
+198
+00:19:08,050 --> 00:19:14,550
+عنها فالمعادلة الثانية، بدنا نتذكر إن واحد يساوي B
+
+199
+00:19:14,550 --> 00:19:20,430
+تربيع زائد اثنين BQ زائد Q تربيع هذولة المحاضرتين،
+
+200
+00:19:20,430 --> 00:19:24,650
+هذولة المعدلتين أنا بتوقع يعني مهمات كثير، الواحد
+
+201
+00:19:24,650 --> 00:19:30,490
+يفهمهمفأنا بدي أعقد الموضوع وأعطيكم إياه إمتحان أو
+
+202
+00:19:30,490 --> 00:19:36,690
+سؤال لنشوف للأسبوع اللي جاي يشتغلوا عليه أنتم
+
+203
+00:19:36,690 --> 00:19:39,810
+ويعطوني
+
+204
+00:19:39,810 --> 00:19:47,890
+الـ Results تبعتكم أفرض أنا مسكتكم كلكم 200 طالب
+
+205
+00:19:47,890 --> 00:19:56,040
+وطالبة وفحصت الـ ABO Systemالـ A-type في الـ
+
+206
+00:19:56,040 --> 00:20:00,740
+medical students in Islamic University of Gaza and
+
+207
+00:20:00,740 --> 00:20:05,440
+found the frequencies as are follows الـ A-type 20
+
+208
+00:20:05,440 --> 00:20:13,980
+% الـ B-type 24% الـ A-B-type 26% الـ O-type 30%
+
+209
+00:20:13,980 --> 00:20:19,660
+فالسؤال What are the frequencies of the alleles in
+
+210
+00:20:19,660 --> 00:20:28,510
+this population؟هنا عقدت الموضوع زيادة يعني لو الـ
+
+211
+00:20:28,510 --> 00:20:38,250
+AB كان كله يعني الـ AB لو إنه كان موجود بهذا الشكل
+
+212
+00:20:38,250 --> 00:20:44,250
+يعني لو كان كروموزومت أليل واحد كانت راح تكون
+
+213
+00:20:44,250 --> 00:20:48,770
+تماماً Classical حسب المعادلات بس هنا أنا حطيت
+
+214
+00:20:48,770 --> 00:20:50,830
+الأثنين فكروا فيها
+
+215
+00:20:53,690 --> 00:21:00,310
+لكل قليل اللي هو الـ A والـ B والـ O أعطيني الـ
+
+216
+00:21:00,310 --> 00:21:11,390
+Frequency تبعتهم الآن محاضرت اليوم يعني
+
+217
+00:21:11,390 --> 00:21:17,410
+كيف أنا بدي أفهم العلاقة
+
+218
+00:21:17,410 --> 00:21:21,030
+الوراثة
+
+219
+00:21:21,030 --> 00:21:27,700
+والـالـ Genetics تبعات أي إنسان وبين إنه يحدث معاه
+
+220
+00:21:27,700 --> 00:21:33,820
+مرض طبعاً يعني بتتدخل فيها مواضيع كثيرة والأمر
+
+221
+00:21:33,820 --> 00:21:39,860
+يعني أحياناً
+
+222
+00:21:39,860 --> 00:21:46,560
+حتى الواحد يشوفه بتكون فيه ظواهر كثيرة يعني قضايا
+
+223
+00:21:46,560 --> 00:21:56,540
+مهمة بالنسبة لـجزء من الـ الـ يعني احنا الأسهل
+
+224
+00:21:56,540 --> 00:22:01,480
+أحيانًا كتير بنتكلم عن الـ الـ الـ الجين الواحد
+
+225
+00:22:01,480 --> 00:22:07,840
+على إنه هذا من الأب و هذا من الأم على كرموزوم كامل
+
+226
+00:22:07,840 --> 00:22:16,440
+وإن الأمور يعني كل كرموزوم بيظلوا زي ما هو الحقيقة
+
+227
+00:22:16,440 --> 00:22:25,630
+أعقد من هيك بكتير أحيانًااللي بيصير إنه لو أخذنا
+
+228
+00:22:25,630 --> 00:22:32,710
+الجيل الأجداد، الجيل الأول ذكروا أنثى، اتزوجوا،
+
+229
+00:22:32,710 --> 00:22:36,650
+وإذا افترضنا كل واحد منهم كان الـChromosome تبعه
+
+230
+00:22:36,650 --> 00:22:43,310
+بهذا الشكل ولوّننا على إن هاي الـTwo copies تبعات
+
+231
+00:22:43,310 --> 00:22:50,260
+الجينات تبعات هذا الإنسان في هذا الموقعوعنا كل
+
+232
+00:22:50,260 --> 00:22:56,640
+واحد منها Two copies لما أنا باجي بدرس ترتيب
+
+233
+00:22:56,640 --> 00:23:06,380
+الجينات تبعات الأبناء والبنات ماشي أحياناً يعني
+
+234
+00:23:06,380 --> 00:23:14,620
+باعتمد على بالذات إذا الأماكن بعيدة عن بعض ماشي،
+
+235
+00:23:14,620 --> 00:23:19,500
+في الـ DNAبلاقي إنه بتصير ظاهرة بنسميها الـ
+
+236
+00:23:19,500 --> 00:23:27,000
+recombination الـ recombination إنه بيصير خلال
+
+237
+00:23:27,000 --> 00:23:34,940
+فترات الـ cell division بيبدأ تكون بالـ gametes
+
+238
+00:23:34,940 --> 00:23:40,520
+يعني بالـ ova و بالـ sperms لما يصير عملية الـ
+
+239
+00:23:40,520 --> 00:23:45,680
+segregation لما يصير عملية الانفصال
+
+240
+00:23:46,020 --> 00:23:53,160
+الـ Two copies عن بعضها، ماشي؟
+
+241
+00:23:53,160 --> 00:23:56,220
+شو
+
+242
+00:23:56,220 --> 00:24:05,000
+اسمه؟ بالنسبة ل، لو فرضنا هنا، هاي بدهم يطلعوا على
+
+243
+00:24:05,000 --> 00:24:14,240
+الـDNA بالذات للـX-Chromosome مثلا بالنسبة للإنسان
+
+244
+00:24:14,240 --> 00:24:22,740
+هذابنلاقي إنه صحيح حجم الـ «DNA» كاملاً هيك متساوي
+
+245
+00:24:22,740 --> 00:24:25,920
+ويعني
+
+246
+00:24:25,920 --> 00:24:35,420
+متشابه بس حقيقةً في قطع في كل كروموزوم بيكون من
+
+247
+00:24:35,420 --> 00:24:44,580
+الـ يعني من النسختين اللي قبل يعني هسة الـ «high»
+
+248
+00:24:44,780 --> 00:24:52,520
+الصور الأصلية للـChromosomes تبعات ذكر الأمتى
+
+249
+00:24:52,520 --> 00:25:01,940
+عندما نأخذ البنت الأولى هذا الـChromosome أخذته من
+
+250
+00:25:01,940 --> 00:25:10,400
+أبوها بس صحيح كان في الغالبهذه النسخة من الـ
+
+251
+00:25:10,400 --> 00:25:17,480
+Chromosome هذا ما هي اللي أخذته؟ بس في البنت بعض
+
+252
+00:25:17,480 --> 00:25:25,780
+القطع من الجينات من النسخة الثانية، ماشي؟ وهي
+
+253
+00:25:25,780 --> 00:25:30,300
+نتيجة أن بين هذه وهذه النسختين إن شاء الله أنكم
+
+254
+00:25:30,300 --> 00:25:34,200
+بتشوفوا المؤشر اللي بتكلم عنه صارت عملية
+
+255
+00:25:34,200 --> 00:25:39,430
+Recombination يطلعليالـ Chromosome من الأب بهذا
+
+256
+00:25:39,430 --> 00:25:44,910
+الشكل فيه الغالبين العظمى الأصل لهذا الـ
+
+257
+00:25:44,910 --> 00:25:49,790
+Chromosome بس أخد شوية من القطع من الـ Chromosome
+
+258
+00:25:49,790 --> 00:25:56,950
+الثاني هذه ظاهرة بنسميها Recombination يعني
+
+259
+00:25:56,950 --> 00:26:05,050
+بالذات إذا الـ Chromosome طويلوكان يعني من
+
+260
+00:26:05,050 --> 00:26:09,490
+الكرموزومات الكبيرة مش الصغيرة بتلاقي إن الظاهرة
+
+261
+00:26:09,490 --> 00:26:15,150
+هذه بتكون نسبتها أعلى ويكون إنها بتحدث وبتكون إنه
+
+262
+00:26:15,150 --> 00:26:21,850
+ما بنفصل هذولة تماماً عن بعض بشكل مستقل تماماً
+
+263
+00:26:21,850 --> 00:26:29,770
+وإنما وإنما بيصير عملية Recombination وهي في كل
+
+264
+00:26:30,110 --> 00:26:39,170
+الجينات ولكل الكرموزومات بحيث إنه لما نصل بعد ثالث
+
+265
+00:26:39,170 --> 00:26:48,110
+generation حقيقة إذا بنلاحظ هنا إنه لما نيجي نربط
+
+266
+00:26:48,110 --> 00:26:56,890
+الكرموزوم تبع الجيل الثالث الواحد منهم موجود في
+
+267
+00:26:56,890 --> 00:27:06,980
+خواصالأربع كروموزومات من الأبوين من الجدين في نفس
+
+268
+00:27:06,980 --> 00:27:14,800
+الكروموزوم فأتأمل أن هذه الخطيئة واضحة أنه عند الـ
+
+269
+00:27:14,800 --> 00:27:21,580
+Cell Division وبالذات في الـ Gametes عشان يتم
+
+270
+00:27:21,580 --> 00:27:29,750
+نقلها يكون هناك اشتراكوعملية ظاهرة الـ
+
+271
+00:27:29,750 --> 00:27:35,010
+Recombination هي كمان ظاهرة مهمة على مستوى الـ
+
+272
+00:27:35,010 --> 00:27:42,530
+Chromosome بس بتأثر على يعني شو المادة الوراثية
+
+273
+00:27:42,530 --> 00:27:49,590
+اللي بيأخذها أي ابن أو بنت من أبائه وأمهاته
+
+274
+00:27:49,590 --> 00:27:54,010
+واجداده بالطريقة هذه فهنا، ظاهرة الـ Recombination
+
+275
+00:27:54,770 --> 00:28:00,490
+وهنا يعني الأصل
+
+276
+00:28:00,490 --> 00:28:06,810
+ماشي اللي بيسموه الـ Independent Assortment إذا
+
+277
+00:28:06,810 --> 00:28:13,890
+كان عندنا يعني حكيت يمكن أنا جملة انتبهت عليها
+
+278
+00:28:13,890 --> 00:28:21,370
+قضية إنه النتائج مندل على الثمان صفات اللي درسها
+
+279
+00:28:22,010 --> 00:28:26,770
+الورد من فوق، لون الحب خضر أو صفر أو مجعلك أو
+
+280
+00:28:26,770 --> 00:28:34,810
+مستديرة الصفات هذه كانت بالصدفة هيك بالنسبة لكل
+
+281
+00:28:34,810 --> 00:28:42,330
+دراساته أنه كل صفة على كروموزوم مختلف فالأصل أن كل
+
+282
+00:28:42,330 --> 00:28:53,500
+كروموزوم يعني يتم انفصاله بشكلمنفصل تماماً معاه عن
+
+283
+00:28:53,500 --> 00:29:03,180
+الآخر بس أحياناً يعني المبدأ اللي أول شيء بنفكر
+
+284
+00:29:03,180 --> 00:29:10,880
+فيه قضية Independent Assortment يعني إذا أنا عندي
+
+285
+00:29:10,880 --> 00:29:17,580
+صفة وراثية A capital و small a على locus one على
+
+286
+00:29:17,580 --> 00:29:24,230
+كرموزوم معينوفيه عندي صفة B على كرموزوم ثاني
+
+287
+00:29:24,230 --> 00:29:32,830
+وبمثلها capital B small b الأصل بما أن هدولا
+
+288
+00:29:32,830 --> 00:29:40,910
+الصفتين على كرموزمين مختلفين الأصل أنه لما يصير
+
+289
+00:29:40,910 --> 00:29:53,600
+assortment يعني انفصال بين الكرموزوماتالأصل أنه
+
+290
+00:29:53,600 --> 00:30:05,100
+يعني إذا مثلًا يكون مثلًا عندنا الـ Individual هذا
+
+291
+00:30:05,100 --> 00:30:11,940
+إذا بنشوف كيف هذا أخذ الـ Capital A الـ G
+
+292
+00:30:11,940 --> 00:30:17,360
+الـChromosome اللي فيه عنده Capital A وأخذالـ
+
+293
+00:30:17,360 --> 00:30:27,860
+Chromosome اللي عنده كابيتل B ماشي الآن
+
+294
+00:30:27,860 --> 00:30:35,660
+احنا هنا اللي بنحكي عنه في ظاهرة الـ Meiosis يعني
+
+295
+00:30:35,660 --> 00:30:40,440
+عند تحدوط الإنقسام المنصي يعني هدولة الثنتين اللي
+
+296
+00:30:40,440 --> 00:30:48,770
+بنحكي عنهم هنا هم الـ Ova والـ Spareفالـ Ova أو
+
+297
+00:30:48,770 --> 00:30:55,310
+الـ Sperm هنا الـ Sperm هذا الحيوان المنوي هذا أخذ
+
+298
+00:30:55,310 --> 00:31:02,110
+الـ Chromosome الـ Capital A والـ Capital B مثلا
+
+299
+00:31:02,110 --> 00:31:07,590
+الاحتمال
+
+300
+00:31:07,590 --> 00:31:13,470
+الثاني أنههذه المجالات كلها مستحيلة لأن كل واحد
+
+301
+00:31:13,470 --> 00:31:18,730
+عندما تقوم بالانفصال بينهم ليس كل الانفصالات
+
+302
+00:31:18,730 --> 00:31:20,550
+تماماً مثل بعض
+
+303
+00:31:25,050 --> 00:31:30,650
+اللي فيها capital A أو نسميها من الأب كمصدر أصلي
+
+304
+00:31:30,650 --> 00:31:36,150
+بنتج عنها أنه
+
+305
+00:31:36,150 --> 00:31:42,050
+في الـSperm ثاني الـA أخد تبع الأب والـB أخد تبع
+
+306
+00:31:42,050 --> 00:31:50,170
+الأم، ماشي؟ فهنا الصورة هذه، ماشي؟ بتبين الأصل في
+
+307
+00:31:50,170 --> 00:31:55,240
+الـIndependent Assortmentيعني الأصل لو الأمور
+
+308
+00:31:55,240 --> 00:32:04,320
+تمامًا يعني أخدناها هنا على صفتين ورافقتين على
+
+309
+00:32:04,320 --> 00:32:10,120
+كرموزمين مختلفين الأصل أنه ما في علاقة بين هذه
+
+310
+00:32:10,120 --> 00:32:17,990
+والثانية، ماشي؟الأمر ممكن يتعقد أكثر من هيك أنه
+
+311
+00:32:17,990 --> 00:32:24,250
+أحيانًا لما أدرس مثلًا صفتين، واحدة هنا A والافترض
+
+312
+00:32:24,250 --> 00:32:33,810
+بالطرف الثاني C من تحت الـA والـC مع بعض وSmall A
+
+313
+00:32:33,810 --> 00:32:39,070
+وSmall C مع بعض، هيك الأصل بلاقي أنه مع
+
+314
+00:32:39,070 --> 00:32:42,490
+الـRecombination وقضية الـ
+
+315
+00:32:45,920 --> 00:32:53,540
+الـ Recombination هذه كظاهرة ممكن تجعلنا أنه يعني
+
+316
+00:32:53,540 --> 00:32:59,300
+هنا صحيح الجامعات
+
+317
+00:32:59,300 --> 00:33:03,740
+هنا في Capital A وهنا Capital B وهنا Small A
+
+318
+00:33:03,740 --> 00:33:09,040
+وSmall B بس هذه طلعت Capital A وSmall B وهذه Small
+
+319
+00:33:09,040 --> 00:33:19,330
+A وCapital Bإنه بالأخير ممكن شو اسمه الـ الـ الـ
+
+320
+00:33:19,330 --> 00:33:24,590
+هنا الـ combination أو الـ recombination طلع بشكل
+
+321
+00:33:24,590 --> 00:33:33,450
+مختلف وبكون هنا شو اسمه؟ بكون هنا بطريقة مختلفة
+
+322
+00:33:33,450 --> 00:33:41,150
+ثانية ماشي ال .. ال ..الـ Recombination يعني هي
+
+323
+00:33:41,150 --> 00:33:45,610
+ظاهرة بتحدث بيكون فيها خلال الـ Cell Division
+
+324
+00:33:45,610 --> 00:33:52,510
+ويروح ويجي وكل مرة بتنقسم الخلايا اللفة الخيط أو
+
+325
+00:33:52,510 --> 00:33:56,230
+لفة الحبل اللي أنا مطلوب في الـ Chromosome أفصله
+
+326
+00:33:56,230 --> 00:34:06,930
+بشكل نظيف وبشكل كاملبصير أنه بصير تبادل في قطع من
+
+327
+00:34:06,930 --> 00:34:13,550
+الـ DNA وبصير عن نتيجة الأمر هذا يعني أنه مش ظاهر
+
+328
+00:34:13,550 --> 00:34:19,970
+أو بيكون Independent Assortment فهي يعني الأصل في
+
+329
+00:34:19,970 --> 00:34:24,970
+الـ Assortment أنه يكون كامل، هيك بنفكر بس في
+
+330
+00:34:24,970 --> 00:34:30,130
+الحقيقة بيكون في عنا اسمها Recombination الأمر هذا
+
+331
+00:34:30,130 --> 00:34:37,940
+مربوط أو مهمفي قضايا إنه لما يكون عندي أكثر من صفة
+
+332
+00:34:37,940 --> 00:34:43,980
+مشتركة مع بعض يعني مثلاً اللي هي بيسموها Linked
+
+333
+00:34:43,980 --> 00:34:49,020
+disequilibrium وراح نتكلم عنها بعدين اللي هي إنه
+
+334
+00:34:49,020 --> 00:34:55,100
+إذا الصفة capital A بتيجي معاها إشي معين ظاهرة
+
+335
+00:34:55,100 --> 00:35:01,580
+الـRecombination بتكون مؤثرة وأوضح لما تكون القطع
+
+336
+00:35:01,580 --> 00:35:08,090
+من الـDNAالقطع أو الجينات على الكروموزوم بعاد عن
+
+337
+00:35:08,090 --> 00:35:15,130
+بعض وفي طول في الكروموزوم فإنه يكون قصير والجينات
+
+338
+00:35:15,130 --> 00:35:19,250
+جانب بعض في الغالب بتركب مع بعض وبتظلها مع بعض
+
+339
+00:35:19,250 --> 00:35:30,050
+فهنا الـ Crossing over بتلاقي يعني ممكن واحد
+
+340
+00:35:30,050 --> 00:35:38,470
+يدرسها خلّينا منيعني هذه النقاط تفاصيلها بالنسبة
+
+341
+00:35:38,470 --> 00:35:46,710
+للـ يعني الـ بالنسبة لتفاصيلها بدنا شيها كتير يعني
+
+342
+00:35:46,710 --> 00:35:49,750
+الـ
+
+343
+00:35:49,750 --> 00:35:54,450
+إذا افترضنا إن الـ
+
+344
+00:35:58,430 --> 00:36:04,470
+لما يكون فيه عندى أكثر من قليل A وB بالنسبة
+
+345
+00:36:04,470 --> 00:36:11,250
+للمشاكل اللي حصلت عندنا الـ Crossing over ماشي إذا
+
+346
+00:36:11,250 --> 00:36:16,170
+افترضنا إنه بالصدفة هنا Capital A و Capital B وهنا
+
+347
+00:36:16,170 --> 00:36:21,250
+Small a و Small b لما يصير عندى هيك الأصليات أو
+
+348
+00:36:21,250 --> 00:36:27,010
+هيك أنا لقيت إشي معين فيه مرات بلاقي إن الـ
+
+349
+00:36:27,010 --> 00:36:32,100
+Productسيكون small a مع capital B أو capital A مع
+
+350
+00:36:32,100 --> 00:36:42,260
+small b ممكن تكون موجودة يعني ماشي يعني يمكن لو
+
+351
+00:36:42,260 --> 00:36:47,360
+يعني
+
+352
+00:36:47,360 --> 00:36:56,700
+ممكن أحيانًا أكثر ظاهرة يعني أنا يعني بفكر فيها
+
+353
+00:36:58,000 --> 00:37:04,580
+بتحدث فيه هذه الشغلة بالنسبة مثلا لـ «HLA Antigen»
+
+354
+00:37:04,580 --> 00:37:09,320
+اللي هم تبعات المناعة اللي هو الـ «MHC Molecules»
+
+355
+00:37:09,320 --> 00:37:13,940
+في عندنا الـ «MHC Molecules» أو الـ «HLA Antigens»
+
+356
+00:37:13,940 --> 00:37:20,940
+الـ «Class I» والـ «Class II» ويكونيعني حتى لقينا
+
+357
+00:37:20,940 --> 00:37:26,260
+أنه لما نيجي نفحص الـ HLA Class I نفحص الـ A والـ
+
+358
+00:37:26,260 --> 00:37:33,100
+B وما نفحصش الـ C السبب أنه لقوا أن الـ B بيمشي
+
+359
+00:37:33,100 --> 00:37:38,640
+معاه C معين فبحيث أنه يعني في الغالب أن الواحد
+
+360
+00:37:38,640 --> 00:37:44,800
+يدرس ويتغلب أنه يدرس الـ HLA C مافيش داعي له يعني
+
+361
+00:37:44,800 --> 00:37:51,950
+سريرياً وعلمياًفي حالات معينة بسبب ظاهرة نسميها
+
+362
+00:37:51,950 --> 00:37:57,190
+«linkage disequilibrium» إنه إذا عندي كابيتال A
+
+363
+00:37:57,190 --> 00:38:03,610
+معين بيكون عندي الـ B كابيتال كمان وإذا الـ B الـ
+
+364
+00:38:03,610 --> 00:38:09,130
+A صغير بلاقي الأليل اللي معاه الـ B صغير مثلا،
+
+365
+00:38:09,130 --> 00:38:14,110
+نفترض ذلك فهذه يعني قضايا
+
+366
+00:38:14,950 --> 00:38:23,230
+أحيانًا زي ظاهرة الـ linkage disequilibrium بتكون
+
+367
+00:38:23,230 --> 00:38:32,210
+نتيجتها إنه يعني راح تكون راح
+
+368
+00:38:32,210 --> 00:38:39,750
+تكون نتيجتها إنه يعني في مجال إنه يتغيروا بحيث إنه
+
+369
+00:38:39,750 --> 00:38:44,310
+كل ما كانوا الجينات
+
+370
+00:38:44,600 --> 00:38:50,900
+مواقعهم قريبة مع بعض راح يكونوا بيمشوا مع بعض وكل
+
+371
+00:38:50,900 --> 00:38:54,880
+ما كانوا مجال إنه يكونوا بعاد عن بعض راح تكون
+
+372
+00:38:54,880 --> 00:38:58,480
+الاحتمالية
+
+373
+00:38:58,480 --> 00:39:02,720
+الـ Recombination ويكون إنه فيه اختلافات أكبر
+
+374
+00:39:02,720 --> 00:39:09,880
+بكثير، ماشي؟ هنا حاطين يعني تقييم للي حكينا
+
+375
+00:39:09,880 --> 00:39:15,530
+الـStrong linkage disequilibriumوالمثال اللي حطيه
+
+376
+00:39:15,530 --> 00:39:21,290
+لكم إياه «ظاهرة الريتينايتس بيجمنتوزا» نفس الـ
+
+377
+00:39:21,290 --> 00:39:26,930
+«جين» المسؤول عنه شكله فيه صعوبة أننا نفحصه أو
+
+378
+00:39:26,930 --> 00:39:31,990
+إحنا مش فاهمين شو دوره وشو هو ولا كده بس اللي
+
+379
+00:39:31,990 --> 00:39:39,270
+بيصير أنه ندرس عن طريق اللي هو بيسموه «marker
+
+380
+00:39:39,270 --> 00:39:46,180
+locus 2»يعني أنه
+
+381
+00:39:46,180 --> 00:39:52,380
+أحيانًا يعني إذا تخيلنا هنا الـ «ريتينايتس
+
+382
+00:39:52,380 --> 00:39:59,780
+بيجمينتوزا» الجين اللي هو الـD هذا فهذا الإنسان
+
+383
+00:39:59,780 --> 00:40:04,940
+هنا هي Female مصابة وعندها الـD Capital لأنه شكله
+
+384
+00:40:04,940 --> 00:40:11,490
+اتزامل dominant، ماشي؟والجين الثاني أو النسخة
+
+385
+00:40:11,490 --> 00:40:16,470
+الثانية طبيعية اللي هي Normal Small Capital تزوجت
+
+386
+00:40:16,470 --> 00:40:23,690
+شخص طبيعي فالآن هاي
+
+387
+00:40:23,690 --> 00:40:29,810
+الجين اللي هو مسبب للمرض ماشي أنا فيه صعوب أني
+
+388
+00:40:29,810 --> 00:40:37,170
+أدرسه فيه لسبب ما مشكلة أني أبحث عليه فإذا
+
+389
+00:40:37,170 --> 00:40:37,790
+لقيت
+
+390
+00:40:40,530 --> 00:40:49,250
+Two markers يعني جينات ثانية أنا وجدت المكافئة لها
+
+391
+00:40:49,250 --> 00:40:53,650
+بحيث أني بقدر أعلم عليها بقدر أعمل زي ما حكينا
+
+392
+00:40:53,650 --> 00:40:58,050
+fluorescence immunofluorescence
+
+393
+00:40:58,050 --> 00:41:02,730
+in-cyto-hybridization اللي هي الـFish مثلا على إنه
+
+394
+00:41:02,730 --> 00:41:06,950
+علاقة موجودة أو لا مش موجودة النسخة اللي أنا بدي
+
+395
+00:41:06,950 --> 00:41:16,990
+إياهافالفكرة أنه في حالة هذا الجين المسبب للمرض
+
+396
+00:41:16,990 --> 00:41:24,070
+هنا إذا عندي Two Markers بحب أستخدمهم الأحسن ليه
+
+397
+00:41:24,070 --> 00:41:30,170
+أنه أستخدم الـ Marker اللي هو الـ B لأن هذا قريب
+
+398
+00:41:30,170 --> 00:41:36,380
+لما يكون قريب إذا كانت Capital B وشفتهامعناته أه
+
+399
+00:41:36,380 --> 00:41:42,160
+والله في الغالب capital D وU وفيه احتمالية أن ..
+
+400
+00:41:42,160 --> 00:41:47,940
+يعني أن نكون ماشيين مع بعض الـ capital A هنا
+
+401
+00:41:47,940 --> 00:41:54,640
+البعيد كـ marker مش كويس السبب أنه مش دائما بمشي
+
+402
+00:41:54,640 --> 00:41:59,220
+معاه هذا يعني حتى في one generation افرض هذول الـ
+
+403
+00:41:59,220 --> 00:42:06,240
+Dodge خلفوا ثمانين وجيت أنا درستالـ Capital D
+
+404
+00:42:06,240 --> 00:42:09,680
+دائماً
+
+405
+00:42:09,680 --> 00:42:16,120
+بيجي معاها Capital B الأصل هنا الـ Capital D أجت
+
+406
+00:42:16,120 --> 00:42:21,280
+معاها Small B، ماشي؟ فهنا صار Recombination بين
+
+407
+00:42:21,280 --> 00:42:26,400
+هذا وهذا، ماشي؟ وهي الـ Capital D أجت معاها
+
+408
+00:42:26,400 --> 00:42:33,160
+Capital B، فهنا من اثنينمن ثلاث مصابين عندهم الـ
+
+409
+00:42:33,160 --> 00:42:40,900
+Capital D ماشي أثنين كان عندهم Capital B وواحد كان
+
+410
+00:42:40,900 --> 00:42:46,960
+Small B فمن ثلاث، أثنين طلعوا الـ Positive مع
+
+411
+00:42:46,960 --> 00:42:53,420
+الشكل المطلوب بينما المصابين، الأسف، الطبيعيين
+
+412
+00:42:53,420 --> 00:43:00,140
+اللي هم الخمس الثانيين، ماشي اللي عندهم Small D،
+
+413
+00:43:00,140 --> 00:43:11,520
+ماشيراح نلاقي إنه هاي «أ» متوقع الأصلي هنا «أ» هنا
+
+414
+00:43:11,520 --> 00:43:17,500
+«أ» هنا «أ» هنا «أ» اللي راح يكون نتيجة الأمر هذا
+
+415
+00:43:17,500 --> 00:43:33,550
+إنه بالنسبة لـ «D» مع الـ «D» ماشيالـ الـ الـ كان
+
+416
+00:43:33,550 --> 00:43:39,850
+الأصل capital A تكون موجودة بس أثنين من ثلاثة كانت
+
+417
+00:43:39,850 --> 00:43:46,550
+موجودة بينما الـ capital A موجودة في غالبية اللي
+
+418
+00:43:46,550 --> 00:43:50,890
+ماعندهم مش الـ disease فاللي بنقوله هنا يعني الـ
+
+419
+00:43:50,890 --> 00:44:00,460
+conclusion أنه الـ الـ marker B ماشيأحسن من الـ
+
+420
+00:44:00,460 --> 00:44:09,820
+Marker A لتشخيص هذا الجين المُصاب، ماشي؟ والظاهرة
+
+421
+00:44:09,820 --> 00:44:15,540
+بنسميها Linkage Dysequilibrium يعني إنه شو
+
+422
+00:44:15,540 --> 00:44:21,020
+احتمالية الـ Two copies أو Two alleles من الـ Same
+
+423
+00:44:21,020 --> 00:44:27,000
+gene يجي دايماً مع بعض، ماشي؟ والأمر مربوط يعني
+
+424
+00:44:27,000 --> 00:44:33,790
+إنه أحياناًحتى لو أنا يعني فاهم أنه متوقع أنه فيه
+
+425
+00:44:33,790 --> 00:44:41,150
+Mendelian disease وفيه mutation معينة نفس الـ
+
+426
+00:44:41,150 --> 00:44:45,050
+mutation اللي مسبب للمرض أنا أحيانًا ما بستطيع
+
+427
+00:44:45,050 --> 00:44:51,410
+أحددها، ما بكون قادر أعرفها بينما إشي قريب منه
+
+428
+00:44:51,410 --> 00:44:56,290
+مربوط معاه دائمًا مافيش الـ recombination between
+
+429
+00:44:56,290 --> 00:45:03,260
+themممكن أستفيد منه في قضية التشخيص
+
+430
+00:45:03,260 --> 00:45:11,560
+وبالتالي أقدر أعرف يعني مثال على ذلك الـ HLA
+
+431
+00:45:11,560 --> 00:45:17,320
+-antigen typing بنسوي الـ typing للـ A والـ B وفي
+
+432
+00:45:17,320 --> 00:45:25,660
+الـ HLA-C الـ C لأنه إذا مثلا الـ B كانت بشكل معين
+
+433
+00:45:26,050 --> 00:45:30,750
+الـ C بتكون بشكل محدد كمان معاها يعني فبالتالي
+
+434
+00:45:30,750 --> 00:45:35,810
+لاقوا إنه مافي فايدة بإنه أنا أبحث على الـ C السبب
+
+435
+00:45:35,810 --> 00:45:40,130
+إنه فيه linkage disequilibrium الـ A و الـ B بعد
+
+436
+00:45:40,130 --> 00:45:44,850
+عن بعض فبالتالي في احتمالية كبيرة إذا بلاقي إشي
+
+437
+00:45:44,850 --> 00:45:52,030
+معينالـ A والـ B ما بقدر أحدد شو هو مش قادر أعرف
+
+438
+00:45:52,030 --> 00:45:57,370
+شو هو أو ما بعرف مافيش يعني الترابط بينهم الأتنين
+
+439
+00:45:57,370 --> 00:46:02,770
+فهي
+
+440
+00:46:02,770 --> 00:46:09,650
+نتيجة قضية الـ Recombination أنه أنا عندي
+
+441
+00:46:09,650 --> 00:46:12,970
+Recombination في أسئلة
+
+442
+00:46:17,450 --> 00:46:25,170
+الـ Recombination يعني بدنا .. يعني أنت .. يعني هي
+
+443
+00:46:25,170 --> 00:46:33,470
+ظاهرة يعني أحيانًا لما نيجي ندرس ال population أو
+
+444
+00:46:33,470 --> 00:46:41,490
+البشر كيف أو كده كيف بتم توريثها، كيف بكون ال ..
+
+445
+00:46:41,490 --> 00:46:48,590
+يعنيانتقالها من شخص لشخص وكيف بيكون مجموعة الصفات
+
+446
+00:46:48,590 --> 00:46:55,050
+بتيجي مع بعض وهي أحيانًا يعني من الظواهر اللي أحنا
+
+447
+00:46:55,050 --> 00:47:01,190
+بنحكي عنه مرات اللي هي انه Polygenetic Disorders
+
+448
+00:47:01,190 --> 00:47:09,690
+أو Conditions أكثر بكثير بتكون أنه الـ … بتكون أنه
+
+449
+00:47:09,690 --> 00:47:16,090
+الـ Recombinationحدث أو ممكن يحدث بس كل ما كانوا
+
+450
+00:47:16,090 --> 00:47:20,150
+القطعتين بعيد عن بعض بيصير الـ Recombination أكثر
+
+451
+00:47:20,150 --> 00:47:25,570
+كل ما كانوا قريبات على بعض بيكون الإمكانية إنه
+
+452
+00:47:25,570 --> 00:47:30,630
+يمشوا اثنين مع بعض أكثر فهذه يعني ظاهرة بتحدث،
+
+453
+00:47:30,630 --> 00:47:35,270
+ظاهرة يعني أحياناً بتكون مهم إن الواحد يتذكرها
+
+454
+00:47:35,270 --> 00:47:42,200
+ويعني أحياناً بتكون له أهمية سريريةمن ناحية كيف
+
+455
+00:47:42,200 --> 00:47:50,360
+نتعامل مع الموضوع هذا فيه أسئلة نفس
+
+456
+00:47:50,360 --> 00:47:57,660
+الفكرة كل ما أبعدوا الجينات عن بعض على الـ DNA على
+
+457
+00:47:57,660 --> 00:48:02,140
+الـ Chromosome احتمال إن يكونوا الـ Alleles
+
+458
+00:48:02,140 --> 00:48:07,720
+مختلفين على البعض بتكون النسبة أكبر فتفاصيل الأمور
+
+459
+00:48:07,720 --> 00:48:16,650
+بتديشيها يعنيtoo much details ماشي الـ load score
+
+460
+00:48:16,650 --> 00:48:23,790
+اللي هو logarithmic نسيت اختصار يعني اللي هو معامل
+
+461
+00:48:23,790 --> 00:48:27,270
+احتمالية
+
+462
+00:48:27,270 --> 00:48:36,710
+انتقال الأليل مع بعض ماشي فهنا
+
+463
+00:48:36,710 --> 00:48:37,750
+three families
+
+464
+00:48:40,600 --> 00:48:48,580
+شو اسمه؟ تفاصيلها خلاص، بلا منها ماشي، تسألونيش
+
+465
+00:48:48,580 --> 00:48:55,500
+يعني بالنسبة ده بدنا ندخل بتفاصيل هنا يعني الـ
+
+466
+00:48:55,500 --> 00:49:00,980
+«take home message» الرسالة اللي بدنا إياها إنه
+
+467
+00:49:00,980 --> 00:49:09,310
+رياضياً أنا ممكن أعبر عن ارتباط قليل معينبأليل
+
+468
+00:49:09,310 --> 00:49:13,110
+آخر، والقصد في الموضوع اللي هي الظاهرة اللي هنا
+
+469
+00:49:13,110 --> 00:49:21,650
+اللي هي أنه أنا ببدأ يعني بالـChromosomes
+
+470
+00:49:21,650 --> 00:49:28,190
+وعليها الأليل في الـLocus مثلا A1 بشكل معين
+
+471
+00:49:28,190 --> 00:49:36,770
+وChromosome ثاني بكون بشكل آخر الـLocus 2 وفيه
+
+472
+00:49:36,770 --> 00:49:43,040
+Capital B وSmall bبالأخير اللي موجود بعد مرور كذا
+
+473
+00:49:43,040 --> 00:49:49,080
+generation وبسبب الـRecombination الأمور راح تكون
+
+474
+00:49:49,080 --> 00:49:54,960
+أنه أي قطعة بتكون الأصول من كل الأصول بتلاقيها
+
+475
+00:49:54,960 --> 00:50:01,120
+موجودة يعني اللي هي كمان هنا اللي هي أنه بيصير هذا
+
+476
+00:50:01,120 --> 00:50:06,220
+الإنسان الـthird generationالـ Chromosome الأول،
+
+477
+00:50:06,220 --> 00:50:09,840
+مع أنه بالأول الواحد هيك بيحب أنه يفكر أنه الـ DNA
+
+478
+00:50:09,840 --> 00:50:18,880
+والـ Cell Division هيك يعني نظيف وكامل وبينفصل
+
+479
+00:50:18,880 --> 00:50:23,620
+بشكل تم إلا أنه الأمور أعقد من هيك وأنه بتصير
+
+480
+00:50:23,620 --> 00:50:28,180
+عملية الـ Recombination ونتيجتها اللي هي Linked
+
+481
+00:50:28,180 --> 00:50:35,820
+Disequilibrium يعني أنه الـ Lociأو المكان على الـ
+
+482
+00:50:35,820 --> 00:50:42,920
+DNA إذا كان قريب مع بعض هنا في الغالب هيمشوا مع
+
+483
+00:50:42,920 --> 00:50:51,640
+بعض بينما لما نكون بأد راح يصير الاختلاف إن هنا
+
+484
+00:50:51,640 --> 00:50:58,040
+مثلًا هاي كابيتل A كابيتل small a في الـ Locus 1
+
+485
+00:50:58,040 --> 00:51:05,880
+وهنا كابيتل B small b في الـ Locus 2النتيجة إذا
+
+486
+00:51:05,880 --> 00:51:13,920
+صار عندي عملية الـ Recombination ماشي هنا هذه
+
+487
+00:51:13,920 --> 00:51:21,540
+النسخة شبيهة بالأصلي بينما هذه جلبه فصار الـ
+
+488
+00:51:21,540 --> 00:51:26,820
+capital A مع small b و الـ small a مع الـ capital
+
+489
+00:51:26,820 --> 00:51:32,480
+B تصير عملية الـ Recombination ماشيتفاصيلها كيف كل
+
+490
+00:51:32,480 --> 00:51:39,260
+واحدة يعني شون
+
+491
+00:51:39,260 --> 00:51:41,420
+الـ non-recombinant و الـ recoisant و الـ
+
+492
+00:51:41,420 --> 00:51:46,220
+recombinant هدولة أثنتين زي بعض بس المهم أنه جلب
+
+493
+00:51:46,220 --> 00:51:51,340
+صارت عملية recombination هنا ماشي بس إذا كانوا
+
+494
+00:51:51,340 --> 00:51:56,810
+قريبين على بعضلا يوجد تجاربًا مرتبطًا، بيبقى كما
+
+495
+00:51:56,810 --> 00:52:03,410
+هو بيبقى .. يعني عندما ندرس باستخدام الـ two loci
+
+496
+00:52:03,410 --> 00:52:08,650
+هذولة بما أنهم قريبين على بعض احتمالية أنه يمشوا
+
+497
+00:52:08,650 --> 00:52:14,390
+مع بعض أكبر بكتير كل ما أبعده بيصير فيه احتمالية
+
+498
+00:52:14,390 --> 00:52:19,330
+أكبر أنه يصير عملية الـ recombination ماشي
+
+499
+00:52:21,210 --> 00:52:31,150
+يعني هنا حاطين أن أحيانًا القطع واللصق بالنسبة للـ
+
+500
+00:52:31,150 --> 00:52:38,610
+Recombination بنتج عنه أنه الكمية
+
+501
+00:52:38,610 --> 00:52:44,170
+أكبر، يعني عدد الخلايا اللي فيها دول أثنين مهشت مع
+
+502
+00:52:44,170 --> 00:52:44,710
+بعض
+
+503
+00:52:47,490 --> 00:52:52,630
+يعني إن السنتين الذولة ماشيت مع بعض أكثر مش في
+
+504
+00:52:52,630 --> 00:52:57,690
+مثلا كل الخلايا أو نص الخلايا أو كده يعني إن شاء
+
+505
+00:52:57,690 --> 00:53:04,210
+الله هذه الفكرة تكون واضحة وتأثيراتها في قضية إنه
+
+506
+00:53:04,210 --> 00:53:10,570
+أحيانًا أنا ماعندي الـ الـ الـ الـ issue محدد للـ
+
+507
+00:53:10,570 --> 00:53:17,150
+gene causing diseaseبكون عندي إشي لإشي قريب منه
+
+508
+00:53:17,150 --> 00:53:21,350
+فإذا عندي الإشي للقريب منه بهمني إنه يكون هذا
+
+509
+00:53:21,350 --> 00:53:26,030
+الإشي قريب جدا على طول ملزق فيه لأنه إذا كان على
+
+510
+00:53:26,030 --> 00:53:29,530
+طول ملزق فيه احتمالية إنه يكون بينهم Recombination
+
+511
+00:53:29,530 --> 00:53:37,610
+قليلة من كل مكان أبعد بيكون الأمور أصعب في أسئلة؟
+
+512
+00:53:43,700 --> 00:53:47,560
+كاريم بده يتكلم يا دكتور، مش عارف يبدو عنده سؤال
+
+513
+00:53:47,560 --> 00:53:54,940
+نعم، فضل حقيقة أنت كنت في سنة وصار هناك
+
+514
+00:53:54,940 --> 00:53:59,280
+combination بين الجنات تصبح فرصة أصعب إنه يمشوا
+
+515
+00:53:59,280 --> 00:54:07,720
+الجنات مع بعض وينتقلوا مع بعض؟ لما أنا أتكلم على،
+
+516
+00:54:07,720 --> 00:54:14,150
+أسا أنا بتكلم على two low sides، يعني مكانينعلى
+
+517
+00:54:14,150 --> 00:54:21,370
+الـ يعني مثلًا أنا بتكلم خاصية الـ ABO group مثلًا
+
+518
+00:54:21,370 --> 00:54:32,830
+مع الـ Rh group ماشي لفصيلة الدم بس إذا الـ ABO
+
+519
+00:54:32,830 --> 00:54:40,290
+Locus قريب Locus يعني محل ما هذا الـ gene موجود
+
+520
+00:54:40,290 --> 00:54:46,570
+الـ Rh قريب كثير عنشو راح يصير؟ بيصير مافي داعي
+
+521
+00:54:46,570 --> 00:54:51,570
+تفحص الـ RH فاهم عليك أيه؟ أو تفحص الـ Ebio
+
+522
+00:54:51,570 --> 00:54:57,950
+بيكفيني واحد لأنه ثاني بلزق فيه جاي معاه يعني كل
+
+523
+00:54:57,950 --> 00:55:04,730
+ما كانوا أبعد ماشي ال .. كل ما كانوا أبعد احتمالية
+
+524
+00:55:04,730 --> 00:55:09,350
+ان يصير الـ recombination أكبر يعني لو جيت في
+
+525
+00:55:09,350 --> 00:55:15,320
+generation معينة أنا عيلة معينة درست عليهاالـ ABO
+
+526
+00:55:15,320 --> 00:55:20,700
+و الـ Rh و روحت دورت وين ما كان الـ «جين» هذا ماشي
+
+527
+00:55:20,700 --> 00:55:26,480
+إذا قريبات كتير على بعض راح ألاقي إنه فيه ارتباط و
+
+528
+00:55:26,480 --> 00:55:34,480
+إنه بيصير هو يعني الـ «ماركر» اللي هو عنديا
+
+529
+00:55:34,480 --> 00:55:41,100
+أستخدمه كمان عشان أدرس هذه الظاهرة بيكون مفيد كتير
+
+530
+00:55:41,100 --> 00:55:47,740
+لأنه قريب كتيرومافيش Recombination وبنسميه فيه
+
+531
+00:55:47,740 --> 00:55:50,840
+Linked Disequilibrium هذه الكلمة اللي بدي إياها
+
+532
+00:55:50,840 --> 00:55:57,880
+اللي هي إنه في عندنا ارتباط بين الـ الـ الـ الـ
+
+533
+00:55:57,880 --> 00:56:03,380
+إذا الأليل هذا A Capital بيجي معاه مثلا الـ B
+
+534
+00:56:03,380 --> 00:56:07,380
+Capital أو بيجي معاه إشي محدد فأنا هيبقى أستفيد من
+
+535
+00:56:07,380 --> 00:56:09,440
+هذه الظاهرة، ماشي؟
+
+536
+00:56:14,880 --> 00:56:22,520
+يعني استخدام هذا المفهوم بروري أحيانًا سريرياً ليش
+
+537
+00:56:22,520 --> 00:56:29,940
+ندرس بشكل معين وأحيانًا أنه أنا ممكن تجينة عالية
+
+538
+00:56:29,940 --> 00:56:39,640
+عندها مرض مايكنش عنده الـ Marker الـ Exact للجين
+
+539
+00:56:39,640 --> 00:56:47,190
+المسبب للمرض فمضطر أنا أستخدمماركر لجين إشي قريب
+
+540
+00:56:47,190 --> 00:56:55,890
+منه إذا الإشي القريب منه هذا اللي استخدمته يعني ما
+
+541
+00:56:55,890 --> 00:56:59,550
+هي الفكرة أنه لما يكون عند عيلة عندها الحالة يعني
+
+542
+00:56:59,550 --> 00:57:03,730
+زي مثلا ما اتكلمنا على إن افترض الـ Retinitis
+
+543
+00:57:03,730 --> 00:57:10,870
+Pigmentosa بهذا الشكل ماشي أب و أم الأم صابة جابوا
+
+544
+00:57:10,870 --> 00:57:17,500
+ثمان أفرادثلاثة مصابين وخمسة مش مصابين هذه الحالة
+
+545
+00:57:17,500 --> 00:57:23,340
+المثالية اللي أنا بروح بدرس ودلقيت عيل زي هيك أنا
+
+546
+00:57:23,340 --> 00:57:28,240
+لما فرجتكم شوفتم تذكروا صورة العقل اللي إيديهم
+
+547
+00:57:28,240 --> 00:57:32,000
+عنده قلنا سمناه أقرب شيء له زي الـInfantile
+
+548
+00:57:32,000 --> 00:57:35,980
+Digital Fibromatosis اللي هي صورة الإدانة بشكل
+
+549
+00:57:35,980 --> 00:57:42,780
+معين فلما تجيني عقل زي هيكأنا في عندى إشكالية إنه
+
+550
+00:57:42,780 --> 00:57:49,100
+أنا ما بعرف مية بالمية الـGene و الـLocus اللي هو
+
+551
+00:57:49,100 --> 00:57:56,910
+مسبب للمرض أنا ما بعرفه بس ممكن أستفيدإذا فيه إشي
+
+552
+00:57:56,910 --> 00:58:01,650
+قريب جدا عليه كأنه أستخدمه كـ Marker بعدين مثلا
+
+553
+00:58:01,650 --> 00:58:11,950
+خلفه جابه شخص يعني صار يعني الإمرأة هذه حملت جابت
+
+554
+00:58:11,950 --> 00:58:16,430
+التاسع يسألوك هذا بدي يطلع مصاب ولا مش مصاب مثلا
+
+555
+00:58:16,430 --> 00:58:21,290
+بدك تدرس وتستفيد من ظاهرة الـ linkage
+
+556
+00:58:21,290 --> 00:58:25,590
+disequilibriumأتكون متأكد، الـ Marker اللي أنا
+
+557
+00:58:25,590 --> 00:58:31,550
+هستخدمه أنا مش متأكد إنه للـ Disease 100% إنما أنا
+
+558
+00:58:31,550 --> 00:58:34,610
+بتوقع إن هو عشان قريب من الـ Disease بقدر أستفيد
+
+559
+00:58:34,610 --> 00:58:44,950
+منه فضمن الدراسة فالـ في الحالة هذه بستخدم
+
+560
+00:58:44,950 --> 00:58:53,070
+الـ Marker وبكون يعني بدأ أكون منتبه إنهالـ Marker
+
+561
+00:58:53,070 --> 00:59:00,990
+اللي لاقيته قداش دقيق في أنه يكون قريب من الـ
+
+562
+00:59:00,990 --> 00:59:06,690
+Disease Gene حيث أنه يكون إذا Marker كويس بيكون
+
+563
+00:59:06,690 --> 00:59:13,050
+الـ Load تبعه ماشي اللي هو المعامل الإرتباط تبعه
+
+564
+00:59:13,050 --> 00:59:16,030
+Code-Theor فهذه النقطة اللي بدنا يحصل
+
+565
+00:59:19,460 --> 00:59:23,900
+دكتور في سؤال من Carmel بتقول إيش الفرق ما بين الـ
+
+566
+00:59:23,900 --> 00:59:29,740
+recombination و ال crossing over هم نفسهم هم نفسهم
+
+567
+00:59:29,740 --> 00:59:38,860
+ال crossing over يعني عملية حدوث انتقال من ال DNA
+
+568
+00:59:38,860 --> 00:59:47,380
+كقطعة من جهة إلى جهة أخرى ماشي النتيجة الأمر هذا
+
+569
+00:59:47,380 --> 00:59:55,940
+أنه هيصير عنديrecombination إنه يعني هو نتيجة
+
+570
+00:59:55,940 --> 01:00:05,100
+نتيجة الحدث هذا يعني المتشابهات يعني ماشي ال
+
+571
+01:00:05,100 --> 01:00:11,480
+crossing over هي الظاهرة اللي بتسببلي القضية
+
+572
+01:00:11,480 --> 01:00:14,820
+بتسببلي
+
+573
+01:00:14,820 --> 01:00:23,420
+قضية ال recombination ماشيالـ يعني تتذكروا لما
+
+574
+01:00:23,420 --> 01:00:28,500
+حكينا مثلا حتى عن زي الـ Down Syndrome الـ
+
+575
+01:00:28,500 --> 01:00:37,100
+Crossing Over ماشي بقطع و لثق في الـ DNA من قطع مش
+
+576
+01:00:37,100 --> 01:00:45,980
+المفروض تكون مع بعض، ماشي؟ فالقطع واللثق أحيانًا
+
+577
+01:00:47,660 --> 01:00:53,660
+بيكونش متساوي أو القطع واللثق راح ينتج عنه إنه فيه
+
+578
+01:00:53,660 --> 01:00:58,660
+قطعة كبيرة زيادة وفيه قطعة صغيرة فهنا شو صار عندي؟
+
+579
+01:00:58,660 --> 01:01:04,580
+هنا صار عندي Crossing Over بس الـ Recombination هي
+
+580
+01:01:04,580 --> 01:01:08,980
+المحصلة النهائية لما يكونوا Balanced لما يكونوا
+
+581
+01:01:08,980 --> 01:01:16,080
+متوازنين لما تكون يعنيبالأخير يقدر ينقر الصفات
+
+582
+01:01:16,080 --> 01:01:21,740
+الوراثية ويولد جنين ويولد طفل ويولد يوجد إنسان
+
+583
+01:01:21,740 --> 01:01:27,800
+جديد فالـ Recombination يعني آليتها الـ Crossing
+
+584
+01:01:27,800 --> 01:01:34,460
+Over بس الـ Crossing Over ممكن يسبب مشاكل غير الـ
+
+585
+01:01:34,460 --> 01:01:40,840
+Recombination أو يعني ظواهر أشد وغير يعنيأسأل،
+
+586
+01:01:40,840 --> 01:01:45,720
+يعني أتمنى يكون الأمر واضح أيوة كريم، إذا عنده
+
+587
+01:01:45,720 --> 01:01:57,080
+سؤال بالنسبة
+
+588
+01:01:57,080 --> 01:02:09,500
+لما ندرس دواهر زي هيك يعني حقيقة من الاشياء
+
+589
+01:02:09,830 --> 01:02:17,770
+اللي عم بيستفيدوا منها هي قضية الـGenome-wide
+
+590
+01:02:17,770 --> 01:02:27,570
+Association Study الـGWAS لما
+
+591
+01:02:27,570 --> 01:02:30,910
+نكون
+
+592
+01:02:30,910 --> 01:02:37,910
+عندنا إمكانية نعمل Sequencing لكل الـDNA لكل 9
+
+593
+01:02:37,910 --> 01:02:45,100
+ملياراتنكليوتايد مرة واحدة وأجي أنا أعملهم، ماشي
+
+594
+01:02:45,100 --> 01:02:56,020
+لما يكون حاجة زي هيك بإمكاني
+
+595
+01:02:56,020 --> 01:03:06,570
+معاها أدرس و أكون يعنيمحدد إذا كان عندي Markers
+
+596
+01:03:06,570 --> 01:03:15,050
+كويسة لبعض الـ Diseases بسير أشوف احتمالية حدوث
+
+597
+01:03:15,050 --> 01:03:22,750
+أمراض معينة وهذه عادة، يعني هذه عبارة عن خدمة
+
+598
+01:03:22,750 --> 01:03:27,870
+متوفرة في الدول المتقدمة يعني مثلًا في أمريكا
+
+599
+01:03:27,870 --> 01:03:32,510
+تعطيهم عينة دم تبعتك، ماشي
+
+600
+01:03:35,540 --> 01:03:41,320
+اللي بيعملوا genome-wide association study اللي
+
+601
+01:03:41,320 --> 01:03:46,200
+اسمه الـ GWAS النتيجة بتاعتها بيسموها «ايمان هاتن
+
+602
+01:03:46,200 --> 01:03:54,300
+بلوت» بيادا الشكل الفكرة أنه يعني
+
+603
+01:03:54,300 --> 01:04:01,530
+نتيجة تبع الأمر هذا أنهسواءً عندي الـ Marker للـ
+
+604
+01:04:01,530 --> 01:04:06,930
+Gene نفسه المصاد والطبيعي وبقدر أفرق بينهم أو
+
+605
+01:04:06,930 --> 01:04:14,530
+Marker لإيش قريب منه بحيث أنه يكون في ارتباط مع
+
+606
+01:04:14,530 --> 01:04:24,930
+الـ Disease معينة بقدر أعطي الإنسان تقرير بحيث أنه
+
+607
+01:04:24,930 --> 01:04:34,160
+يعنيإذا الواحد بيشوف الأشياء اللي موجودة، ماشي
+
+608
+01:04:34,160 --> 01:04:41,340
+مثلًا SF1 اللي هو Cystic Fibrosis Inheritance
+
+609
+01:04:41,340 --> 01:04:50,840
+مثلًا Adams، فيه Adams 13 تبع مثلًا الـTTP اللي هو
+
+610
+01:04:50,840 --> 01:04:56,140
+«Thrombotic Thrombocytopenic Fever» مش عارف كده
+
+611
+01:04:56,660 --> 01:05:04,900
+فالفكرة أنه من الاستفادات لقضية الـ Recombination
+
+612
+01:05:04,900 --> 01:05:11,340
+ومن الاستفادات في بالذات اللي بيسموه الـ
+
+613
+01:05:11,340 --> 01:05:15,560
+Individualized Medicine يعني إن أنا أحاول أدرس
+
+614
+01:05:15,560 --> 01:05:21,010
+التركيب الجيني تبع الإنسان اللي أماميبحيث أفهم هو
+
+615
+01:05:21,010 --> 01:05:26,930
+محتمل أكثر يصيبوا إيش وما يصيبوش إيش بهذا الشكل
+
+616
+01:05:26,930 --> 01:05:34,270
+بأستخدم كلمة بدي إياكم تتذكروها اسمها «Genome-wide
+
+617
+01:05:34,270 --> 01:05:43,890
+Association Studies» GWAAS هذه مبدأ تقني مبدأ
+
+618
+01:05:43,890 --> 01:05:57,880
+مختبري بيعمل بطريقة معينةبدور على هنا الـ Single
+
+619
+01:05:57,880 --> 01:06:04,120
+Nucleotide Polymorphism Alleles على إشي معين
+
+620
+01:06:04,120 --> 01:06:12,760
+بالأخر يعني شفت أنا تقارير الـ Report اللي طلعوا
+
+621
+01:06:12,760 --> 01:06:20,160
+زي ما كنا في مرة من قبل يعني شبيه بأنه يعطيكوالله
+
+622
+01:06:20,160 --> 01:06:29,620
+انت 60% أو 50% قوقازي 40% أسياوي، 6% أفريقي مش
+
+623
+01:06:29,620 --> 01:06:35,460
+عارف من وين انت جيت يعني زي هذه الظاهرة بعطيني
+
+624
+01:06:35,460 --> 01:06:43,940
+كمان تقرير على إنه عندك احتمالية مثلًا 20% يكون
+
+625
+01:06:43,940 --> 01:06:46,620
+معاك سكري عندك احتمالية 10%
+
+626
+01:06:49,300 --> 01:06:54,940
+يكون معاك مثلاً ضغط عندك نسبة واحد بالمائة يكون
+
+627
+01:06:54,940 --> 01:07:00,280
+عندك Alzheimer عندك واحد بالمائة نسبة كذا يعني
+
+628
+01:07:00,280 --> 01:07:05,320
+بعطيك الاحتماليات
+
+629
+01:07:05,320 --> 01:07:08,940
+وبكون
+
+630
+01:07:08,940 --> 01:07:17,660
+يعني هذه بدك تدخل بتفاصيل دقيقة كيف انعملت وشو
+
+631
+01:07:17,660 --> 01:07:22,080
+اللي انعملزي ما انتوا شايفين هنا يعني هنا اللي هما
+
+632
+01:07:22,080 --> 01:07:27,480
+الـ 22 كروميزون والـ
+
+633
+01:07:27,480 --> 01:07:33,420
+X والـ Y المفروض يكونوا كمان موجودين وبيعطيك تقرير
+
+634
+01:07:33,420 --> 01:07:40,540
+انت شو متوقع الأمراض اللي انت تكون تعاني منها أو
+
+635
+01:07:40,540 --> 01:07:45,720
+إلك احتمالية يكون عندك فيها وشكله الـ Report
+
+636
+01:07:45,720 --> 01:07:55,640
+بيعطيك فكرةإنه كام قرب هذا الـ Crow أليل بهذا
+
+637
+01:07:55,640 --> 01:08:01,940
+الشكل مع الـ Disease بيعطيك نسبة احتمالية إنك يكون
+
+638
+01:08:01,940 --> 01:08:06,240
+عندك هذا الـ Disease يعني و أنا 300 مرة أكثر من
+
+639
+01:08:06,240 --> 01:08:13,640
+الإنسان الطبيعي أو يعني مضاعف و شكل لغريثمي و أنا
+
+640
+01:08:13,640 --> 01:08:22,940
+القراءة فـيعني أنه الآن الفكرة أنه باستخدام الـ
+
+641
+01:08:22,940 --> 01:08:25,920
+Linkage Disequilibrium أو الـ Recombination
+
+642
+01:08:25,920 --> 01:08:31,740
+Studying وإذا عندي آليات
+
+643
+01:08:31,740 --> 01:08:39,020
+أو تقنية أو آلات تقدر تعمل Whole Genome Sequencing
+
+644
+01:08:39,020 --> 01:08:49,230
+كامل لكل الـ DNA بإمكاني أني بالأخير أطلعاحتمالات
+
+645
+01:08:49,230 --> 01:08:55,030
+logarithmية أو احتمال الإصابة
+
+646
+01:08:55,030 --> 01:08:58,910
+كاريم
+
+647
+01:08:58,910 --> 01:09:03,270
+بيسأل، بقول، يعني بناء على شو بيعطي احتمالية حدوث
+
+648
+01:09:03,270 --> 01:09:06,550
+المرض يعني افسدوا احتمالية حدوث المرض، ايش بيجيس؟
+
+649
+01:09:06,550 --> 01:09:18,580
+لأ، الامر بتكلم على انه انا عندي أداءعندى tool
+
+650
+01:09:18,580 --> 01:09:24,540
+بستفيد منها هاي في دول اللي فاضين وعندهم إمكانات
+
+651
+01:09:24,540 --> 01:09:33,320
+يعملوا أشياء زي هيك بدك أنت يعني بشكل مسبق بشكل
+
+652
+01:09:33,320 --> 01:09:40,960
+يعني استشراف للمستقبل لشوه احتمالية أنه إنسان يكون
+
+653
+01:09:40,960 --> 01:09:44,280
+عنده الحالة اللي فلانية فاهم عليك كده؟
+
+654
+01:09:46,900 --> 01:09:56,740
+فالموضوع أنه أنت عندك الـ Tool أنك تقدر تفحص كل
+
+655
+01:09:56,740 --> 01:10:02,280
+الجينات أو كل الـ DNA وتقراها كلها بضاربة واحدة،
+
+656
+01:10:02,280 --> 01:10:08,280
+ماشي؟ يعني زي تقول، إذا الواحد بتذكر أيام زمان
+
+657
+01:10:08,280 --> 01:10:13,460
+الكمبيوترات كانت بطيقةالان الكمبيوترات سريعة وقوية
+
+658
+01:10:13,460 --> 01:10:18,040
+جداً جداً جداً فانت عندك زي هيك يعني زي ما تقول
+
+659
+01:10:18,040 --> 01:10:26,400
+كنت زمان اتدور على نرجع على قضية القصائد والكلمات
+
+660
+01:10:26,400 --> 01:10:37,200
+والأحرف كنت بدك مثلا لو عندك مكتب ورقيهوأقولك بيت
+
+661
+01:10:37,200 --> 01:10:44,640
+الشعر الفلاني مين جابه؟ مين عمله؟ مين قاله؟ بتتغلب
+
+662
+01:10:44,640 --> 01:10:50,080
+جداً ومليارات يعني آلاف الكتب وكيف بدك تدور عليه
+
+663
+01:10:50,080 --> 01:10:54,720
+فينما حسة لما يكون عندك زي Google Search بتحط
+
+664
+01:10:54,720 --> 01:10:59,780
+الكلمتين تلاتي بتطلعلك خيارات خلال seconds أو
+
+665
+01:10:59,780 --> 01:11:04,080
+milliseconds أو nanosecondsخلال فترة قصيرة جدا
+
+666
+01:11:04,080 --> 01:11:09,620
+بتجيبك احتمالية بيفهم عليك من وين على شو أنت بتدور
+
+667
+01:11:09,620 --> 01:11:16,260
+يعني فالفكرة شبيهة في هذه الحدث يعني أنه أنا الـ
+
+668
+01:11:16,260 --> 01:11:22,740
+DNA عبارة عن كلمات وأحرف وكذا الآن أحياناً الكلمة
+
+669
+01:11:22,740 --> 01:11:26,880
+هذه في بيت الشعر هذا في البروتين هذا في القصيدة
+
+670
+01:11:26,880 --> 01:11:31,950
+الفلانيةأحيانًا مش هو نفسه المسبب للمرض 100% أنا
+
+671
+01:11:31,950 --> 01:11:37,270
+قد لا أكون متأكد من هذا الموضوع بس بيظل إنه إذا
+
+672
+01:11:37,270 --> 01:11:41,270
+بقدر أعمل Search لكل إنسان أو للإنسان اللي بيجي
+
+673
+01:11:41,270 --> 01:11:49,450
+عندى، ماشي، على المستشفى، بكون، شو اسمه؟ بكون عندى
+
+674
+01:11:49,450 --> 01:11:53,590
+آليات أحسن إني أدرس الموضوع هذا، ماشي؟
+
+675
+01:11:57,130 --> 01:12:01,730
+الموضوع مش إنه أنا بكون واثق إن هذا الإنسان راح
+
+676
+01:12:01,730 --> 01:12:05,590
+يصيب المرض الإفلاني ما بقدر أحكي الكلام هذا الكلام
+
+677
+01:12:05,590 --> 01:12:12,310
+يعني الاستنتاج اللي راح يجيه إنه فيه احتمالية بقدر
+
+678
+01:12:12,310 --> 01:12:18,270
+أعطيها نسب أو حسب قربها وحسب ثقة بالنسبة للموضوع
+
+679
+01:12:18,270 --> 01:12:22,630
+هذا بعطيها نسب يا إما عالي كتير يا إما واطي أو أقل
+
+680
+01:12:22,630 --> 01:12:30,270
+أو كدهماشي بالنسبة
+
+681
+01:12:30,270 --> 01:12:36,710
+لـ .. يعني أحياناً
+
+682
+01:12:36,710 --> 01:12:42,750
+يعني خلّينا نتذكر نقطة وأنا باعتبر يعني الأهم هي
+
+683
+01:12:42,750 --> 01:12:47,550
+وجود المفاهيم إذا أنا شكيت أنه فيه disease
+
+684
+01:12:47,550 --> 01:12:51,450
+chromosomal أو disease
+
+685
+01:12:52,750 --> 01:12:58,530
+يعني sub-chromosome أو باند فيها مشكلة شو بدي
+
+686
+01:12:58,530 --> 01:13:03,770
+أعمل؟ إذا أنا شكيت في عيلة عندها شغل زي هيك بروح
+
+687
+01:13:03,770 --> 01:13:08,910
+بعملهم بينقصين الـ karyotype الـ karyotype هو اللي
+
+688
+01:13:08,910 --> 01:13:12,930
+بيخليني أشوف الـ chromosome كله وبقدر أشوف إذا فيه
+
+689
+01:13:12,930 --> 01:13:19,090
+باند ضايعة باند منقولة باند صار فيها مشكلةوممكن
+
+690
+01:13:19,090 --> 01:13:25,910
+أستفيد من هذا الموضوع كـ Band في تشخيص أشياء معينة
+
+691
+01:13:25,910 --> 01:13:29,090
+النوع
+
+692
+01:13:29,090 --> 01:13:36,250
+الثاني من عمليات الـ Search بتكون باستخدام قطعة
+
+693
+01:13:36,250 --> 01:13:44,770
+يعني مثلًا أنا الـ الـ الـ الـ اللي حكينا الـ
+
+694
+01:13:44,770 --> 01:13:52,810
+Nucleotides زي الأحرففلما أجي أعمل Search بدي على
+
+695
+01:13:52,810 --> 01:14:00,090
+مستوى أن أحط كلمة ماشي و أدور عليها بقدر أسوي هيك
+
+696
+01:14:00,090 --> 01:14:05,130
+إذا أنا متأكد وين هي بس أنا عندى تسع مليارات حرف و
+
+697
+01:14:05,130 --> 01:14:10,570
+أني أدور فيهم كلهم بهذه الطريقة أحياناً صعب و
+
+698
+01:14:10,570 --> 01:14:15,840
+بيبقى عندى احتمالات كبيرة و لأي إنسان الـ Snapاللي
+
+699
+01:14:15,840 --> 01:14:19,840
+هي Single Nucleotide Polymorphism يعني اختلالات أو
+
+700
+01:14:19,840 --> 01:14:25,300
+اختلافات في Single Nucleotide عشر ملايين اختلال
+
+701
+01:14:25,300 --> 01:14:31,340
+عادة في أي إنسان منها فبتصير الأمور صعبة وبصير
+
+702
+01:14:31,340 --> 01:14:36,900
+يعني أني أكون بثقة متأكد من هذا الموضوع صعب
+
+703
+01:14:36,900 --> 01:14:40,900
+فالأمور اللي سووها كثير من العلماء لما ييجوا
+
+704
+01:14:40,900 --> 01:14:46,700
+يدرسوا أمراض معينة ووراثيةبيصير زي مثلًا Retinitis
+
+705
+01:14:46,700 --> 01:14:50,920
+Pigmentosa هذا النوع من الـ Disease Retinitis
+
+706
+01:14:50,920 --> 01:14:56,900
+Pigmentosa أنا بطلعلها Marker يعني أنا بكون درست
+
+707
+01:14:56,900 --> 01:15:03,440
+من قبل وين الجين وأحيانًا صعد علي أني أشوف حتى لو
+
+708
+01:15:03,440 --> 01:15:12,680
+يعني حتى لو بشوف أنه في منطقة فيها ارتباط أقوى
+
+709
+01:15:13,370 --> 01:15:18,210
+أحياناً بكون عندي صعوبة أن أتأكد أنه هل هو فعلاً
+
+710
+01:15:18,210 --> 01:15:22,350
+هذا الأمر هو المهم المثال هنا اللي بدي أحطهنيا
+
+711
+01:15:22,350 --> 01:15:30,650
+اللي هو أنه لما أنت تيجيك حالة وتيجيك عيلة أنت
+
+712
+01:15:30,650 --> 01:15:37,770
+بتكون من الـ pedigree يعني شاكك أن هذا مرض وراثي
+
+713
+01:15:37,770 --> 01:15:47,810
+وهذا مرض جينيوإذا بالذات يعني بكون يعني هذا مرض
+
+714
+01:15:47,810 --> 01:15:58,250
+وراثي وجيني بدي أفكر كيف بدي أجي أنا أعمل الأحسن
+
+715
+01:15:58,250 --> 01:16:04,730
+أنه أعمل Whole Genome Sequencing بكون قريت لكل
+
+716
+01:16:04,730 --> 01:16:09,330
+الناس إذا بالذات أنا بتكلم عن الأسرة اللي عندها
+
+717
+01:16:09,330 --> 01:16:16,210
+المرضوعندي أفراد مصابين وأفراد مش مصابين، ماشي؟
+
+718
+01:16:16,210 --> 01:16:20,050
+لما يكون عندي الـ Whole Genome Sequencing أني
+
+719
+01:16:20,050 --> 01:16:27,910
+أقارن بينهم أحياناً يعني راح يكون الأمر يعني صعب
+
+720
+01:16:27,910 --> 01:16:35,750
+جداً حتى على أقوى كمبيوتر أنه يسوي، ماشي؟ اللي
+
+721
+01:16:35,750 --> 01:16:44,470
+بتكلموا عنه هناإنه افرض أنك لقيت عيلة وعندك مجموعة
+
+722
+01:16:44,470 --> 01:16:51,450
+أفراد مصابين ومجموعة أفراد مش مصابين وقريت الـ
+
+723
+01:16:51,450 --> 01:16:54,650
+«هول
+
+724
+01:16:54,650 --> 01:16:59,370
+جينوم» الـ Sequence تبعهم وعندك إياهم وعندك
+
+725
+01:16:59,370 --> 01:17:04,890
+الكمبيوتر زي «جوجل سيرتش» بيقدر يعملك البحث بحيث
+
+726
+01:17:04,890 --> 01:17:10,010
+أنه يقارن بين المصابين وغير المصابينعندما تكون
+
+727
+01:17:10,010 --> 01:17:17,090
+عمياناً من الأول تقدر أنه ستجد حوالي أربع ملايين
+
+728
+01:17:17,090 --> 01:17:23,590
+اختلاف بين المصابين وغير المصابين يعني هذولة عدد
+
+729
+01:17:23,590 --> 01:17:29,150
+هائل جداً من الاختلافات والاحتمالية الكبرى يعني
+
+730
+01:17:29,150 --> 01:17:35,930
+إذا تتذكروا كلمة حكيتها من قبلإن حوالي 94% من الـ
+
+731
+01:17:35,930 --> 01:17:40,390
+«DNA» في الإنسان هو «Non-coding DNA» يعني
+
+732
+01:17:40,390 --> 01:17:44,890
+«Intervening DNA» الـ «DNA» ما لهوش دخل بالـ
+
+733
+01:17:44,890 --> 01:17:49,110
+Transcription و Translation و تكوين بروتين ويمكن
+
+734
+01:17:49,110 --> 01:17:53,290
+شوية له دور في الـ Regulation يعني إذا ماكنش
+
+735
+01:17:53,290 --> 01:17:58,290
+coding 100% بعضه يعني على أساس بيعتبروه بيحمي ضد
+
+736
+01:17:58,290 --> 01:18:02,540
+الـ Mutations ولو صارتخريب في هذا المكان، بس هو مش
+
+737
+01:18:02,540 --> 01:18:07,960
+مهم، مالوش قيمة فلما بتقدر أنه فيه أربع ملايين
+
+738
+01:18:07,960 --> 01:18:16,760
+اختلاف لما تلاقي، يعني تيجي تحاول تدرس أكثر مين
+
+739
+01:18:16,760 --> 01:18:22,980
+قريب على بروتين يمكن إله وظيفة مين قريب على منطقة
+
+740
+01:18:22,980 --> 01:18:34,100
+معروفة من قبل، كذا ممكن أحددهم لـ 80 ألفلما ألاقى
+
+741
+01:18:34,100 --> 01:18:41,300
+الـ 180 ألف اختلاف بحاول أشوف إذا فيه لهم نتائج
+
+742
+01:18:41,300 --> 01:18:42,940
+على الـ Messenger RNA
+
+743
+01:18:46,550 --> 01:18:55,770
+بحاول أني أقلل أو أدرس من الـ Public databases هنا
+
+744
+01:18:55,770 --> 01:19:02,450
+إذا شوه إشي معروف من قبل قريب مرتبط مع هذه الحالة
+
+745
+01:19:02,450 --> 01:19:07,190
+أو هذا المرض أو إشي قريب منه وبظلني بعدين يعني
+
+746
+01:19:07,190 --> 01:19:16,890
+أركز في الدراسة لحد ما أحاول إذا بقدر أني أحددالـ
+
+747
+01:19:16,890 --> 01:19:22,750
+Variants، أحدد ما هي الـ Alleles أو أكون بينتج عن
+
+748
+01:19:22,750 --> 01:19:27,850
+هذا الجهد كله بالأخير Segment اللي يمكن نسميه
+
+749
+01:19:27,850 --> 01:19:36,510
+Marker واللي بيسموه Candidate Gene Methodology
+
+750
+01:19:36,510 --> 01:19:42,070
+يعني اللي هي أني أنا أدور على أنهار جين اللي مرتبط
+
+751
+01:19:42,420 --> 01:19:49,820
+بقوة كاختلاق بين المصابين وبين الطبيعيين في
+
+752
+01:19:49,820 --> 01:19:57,440
+العائلة هذه في المرض هذا في الحالة هذه يعني شغل
+
+753
+01:19:57,440 --> 01:20:03,940
+نستخدمها وأحياناً في بعض الأمراض بعض العائلات بعض
+
+754
+01:20:03,940 --> 01:20:10,980
+الـ populations نشتغل هذا الشغل فمن هذا الشغل إذا
+
+755
+01:20:11,670 --> 01:20:20,310
+استطعت أجيب Marker متخصص لـ Disease معينة بصير أنا
+
+756
+01:20:20,310 --> 01:20:24,650
+بعدين كفي دراسات أخرى زي الـ Whole Genomes
+
+757
+01:20:24,650 --> 01:20:30,100
+Association Genome-Wide Association Studiesماشي
+
+758
+01:20:30,100 --> 01:20:33,120
+بسير
+
+759
+01:20:33,120 --> 01:20:37,040
+أشوف إذا الـ Marker هذا موجود بقول أه والله
+
+760
+01:20:37,040 --> 01:20:44,660
+احتمالية المرض هذا بنسبة هالقدة أكثر من الناس
+
+761
+01:20:44,660 --> 01:20:52,740
+الطبيعية فهي يعني يعني برجع مرة ثانية الأهم واحد
+
+762
+01:20:52,740 --> 01:20:56,500
+يكون فاهم المبدأ يمكن مايكونش عندنا إمكانية نطبق
+
+763
+01:20:56,500 --> 01:21:04,800
+هذه الأشياءوصراحة مرات يعني .. يعني بتكون .. شو
+
+764
+01:21:04,800 --> 01:21:10,300
+بده أسميها؟ يعني بتكون مضيعة للقدرات إن الواحد
+
+765
+01:21:10,300 --> 01:21:14,160
+يدرس أشياء كثيرة وبيكون زي ما بيقولوا Big Data
+
+766
+01:21:14,160 --> 01:21:20,240
+يكون عندك أرقام كثيرة ومعلومات كثيرة الآن إذا
+
+767
+01:21:20,240 --> 01:21:27,450
+تخيلنا الـالـ Google Search مثلاً كيف بدورلك على
+
+768
+01:21:27,450 --> 01:21:31,530
+الكلمة وبتجيبلك إياها في أي قصيدة، في أي إشي قدر
+
+769
+01:21:31,530 --> 01:21:38,770
+هو مفيد، ممكن بس هي الفكرة أن هذا الموضوع لسه
+
+770
+01:21:38,770 --> 01:21:46,470
+بحاجة لتطوير أكثر، مشاركة أكثر وانتباه للاختلافات
+
+771
+01:21:46,980 --> 01:21:55,100
+يعني حتى لو لقينا إشي يمكن زابط كنسبة في الأمركام
+
+772
+01:21:55,100 --> 01:22:00,260
+في البيض في السود في كده قد لا يكون بالضرورة هو
+
+773
+01:22:00,260 --> 01:22:07,580
+اللي عنا إحنا كمثلًا عرب أو في منطقة الشرق الأوسط
+
+774
+01:22:07,580 --> 01:22:12,560
+أو بلاد الشام أو كده يعني هذه اختلافات بدي الواحد
+
+775
+01:22:12,560 --> 01:22:18,840
+يتنبأ إليها الأهم من هيك يكون الواحد منناعنده تصور
+
+776
+01:22:18,840 --> 01:22:26,720
+على معنى اللي بيقراه وبيشوفه لما نتكلموا على إن
+
+777
+01:22:26,720 --> 01:22:31,600
+هذا Marker للـ Disease يعني يفهمها الواحد، ونتيجة
+
+778
+01:22:31,600 --> 01:22:36,480
+الـ Marker نتيجة حدوث ظاهرة الـ Recombination و
+
+779
+01:22:36,480 --> 01:22:41,200
+الـ Crossover و الـ Linkage Dysequilibrium في
+
+780
+01:22:41,200 --> 01:22:46,280
+تفاوت بين الـ Markers، يعنيقد لا يكون الـ Marker
+
+781
+01:22:46,280 --> 01:22:52,700
+اللي بتستخدمه هو السليم أحكوا، ده فيه أسئلة؟ إيه،
+
+782
+01:22:52,700 --> 01:22:57,820
+كريم بده يتكلم في استفسارين؟ نعم، فضل يا كريم
+
+783
+01:22:57,820 --> 01:23:01,380
+باعظك
+
+784
+01:23:01,380 --> 01:23:04,560
+صورة في الـ chats ممكن برضه مقال ممكن تعرفي شوفها
+
+785
+01:23:04,560 --> 01:23:10,600
+شول أحكي أحكيها كمبدأ يعني ما الصورة هيك أثبت ده
+
+786
+01:23:10,600 --> 01:23:20,380
+قد أنزله كدهلأن جيتها في الـ «بديجري» ‏- أه ‏- في
+
+787
+01:23:20,380 --> 01:23:24,480
+حالة الـ «بديجري» ‏- أه ‏- لما تكون مثلا في ميل
+
+788
+01:23:24,480 --> 01:23:27,460
+محطومك تحتها ساهم واحد ‏- أه ‏- بدون ما تكون عاملة
+
+789
+01:23:27,460 --> 01:23:37,800
+تزاوج ‏- أه ‏- مع ميل الآخر ‏- خليني أشوف ‏- أه ‏-
+
+790
+01:23:37,800 --> 01:23:40,160
+عرضت الصورة أنا يا دكتور ‏- أه ‏- حملتها وعرضتها
+
+791
+01:23:40,160 --> 01:23:47,470
+أنا ‏- أههي موجودة أكتر من قديم، مش الموضوع الـ X
+
+792
+01:23:47,470 --> 01:23:52,410
+-linked dominant inheritance disorder الـ X-linked
+
+793
+01:23:52,410 --> 01:23:52,530
+dominant inheritance disorder الـ X-linked
+
+794
+01:23:52,530 --> 01:23:54,270
+dominant inheritance disorder الـ X-linked
+
+795
+01:23:54,270 --> 01:23:54,490
+dominant inheritance disorder الـ X-linked
+
+796
+01:23:54,490 --> 01:23:56,190
+dominant inheritance disorder الـ X-linked
+
+797
+01:23:56,190 --> 01:23:56,510
+dominant inheritance disorder الـ X-linked
+
+798
+01:23:56,510 --> 01:23:56,930
+dominant inheritance disorder الـ X-linked
+
+799
+01:23:56,930 --> 01:23:58,890
+dominant inheritance disorder الـ X-linked
+
+800
+01:23:58,890 --> 01:23:58,890
+dominant inheritance disorder الـ X-linked
+
+801
+01:23:58,890 --> 01:23:58,970
+dominant inheritance disorder الـ X-linked
+
+802
+01:23:58,970 --> 01:23:59,090
+dominant inheritance disorder الـ X-linked
+
+803
+01:23:59,090 --> 01:23:59,090
+dominant inheritance disorder الـ X-linked
+
+804
+01:23:59,090 --> 01:23:59,090
+dominant inheritance disorder الـ X-linked
+
+805
+01:23:59,090 --> 01:23:59,090
+dominant inheritance disorder الـ X-linked
+
+806
+01:23:59,090 --> 01:23:59,090
+dominant inheritance disorder الـ X-linked
+
+807
+01:23:59,090 --> 01:23:59,090
+dominant inheritance disorder الـ X-linked
+
+808
+01:23:59,090 --> 01:23:59,350
+dominant inheritance disorder الـ X-linked
+
+809
+01:23:59,350 --> 01:23:59,750
+dominant inheritance disorder الـ X-linked
+
+810
+01:23:59,750 --> 01:24:01,270
+dominant inheritance disorder الـ X-linked
+
+811
+01:24:01,270 --> 01:24:04,210
+dominant inheritance disorder الـ X-linked
+
+812
+01:24:04,210 --> 01:24:06,890
+dominant inheritance disorder الـ X-linked
+
+813
+01:24:06,890 --> 01:24:09,260
+dominant inheritance disorder الـ X-linkedلما
+
+814
+01:24:09,260 --> 01:24:12,080
+يعطيك حالة في الحالة هذه يقول لك اللي هو ال female
+
+815
+01:24:12,080 --> 01:24:16,480
+أنا تزوجها اللي معها يكون افترضه دايما سليم ولا
+
+816
+01:24:16,480 --> 01:24:24,000
+ممكن يكون mutant عادي؟ ما هو ليش ماحطهاش؟ لأنه
+
+817
+01:24:24,000 --> 01:24:31,400
+ماعنديش معلومة فاهم عليك كيف؟ يعني هنا الـ بكتير
+
+818
+01:24:31,400 --> 01:24:33,080
+احسانات نعم
+
+819
+01:24:36,400 --> 01:24:40,700
+كتير في صور زيكي في الكتاب بيكون حاطة كل .. بقولك
+
+820
+01:24:40,700 --> 01:24:43,620
+كتير في صور تكون في الكتاب حاطة نفس ال .. الوصف
+
+821
+01:24:43,620 --> 01:24:47,060
+نفسها معين في degree وعمل بس أفره زيكي من دون أن
+
+822
+01:24:47,060 --> 01:24:50,880
+يعمل تزاوج فاهمت أنها .. هذي بتكون ال .. أنه مش
+
+823
+01:24:50,880 --> 01:24:53,960
+عارف ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+824
+01:24:53,960 --> 01:24:55,520
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+825
+01:24:55,520 --> 01:24:55,800
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+826
+01:24:55,800 --> 01:24:58,640
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+827
+01:24:58,640 --> 01:24:58,960
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+828
+01:24:58,960 --> 01:25:00,020
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+829
+01:25:00,020 --> 01:25:00,420
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+830
+01:25:00,420 --> 01:25:08,610
+.. ال .. ال .. ال .. الماوصلتوش، فاهم علي؟ يعني
+
+831
+01:25:08,610 --> 01:25:16,050
+أنا جيت أعملت دراسة على عائلة معينة والأبو مسافر،
+
+832
+01:25:16,050 --> 01:25:21,750
+مش في البلد، مش في المنطقة، فأه الفكرة أنه ماعنديش
+
+833
+01:25:21,750 --> 01:25:25,930
+معلومة عنه، بس طبعاً لازم عشان خلفت، لازم اتزوجت
+
+834
+01:25:25,930 --> 01:25:33,350
+مع شخص آخر، و بفترض أنه سليم، ماشي؟لو كنت عرفت
+
+835
+01:25:33,350 --> 01:25:38,690
+منها إنه مصاب من نفس الإصابة بدا أحطه بس الفكرة
+
+836
+01:25:38,690 --> 01:25:44,890
+هنا إنه هذه كـ Disease أو بـ degree لظاهرة إنه إذا
+
+837
+01:25:44,890 --> 01:25:50,710
+في صفة X-linked dominant إذا الـ X-linked dominant
+
+838
+01:25:50,710 --> 01:25:55,850
+إحنا عادة نتكلم X-linked recessive الـ X-linked
+
+839
+01:25:55,850 --> 01:26:01,910
+dominant الأنثى لو عنده نسخة واحدةبتلاقيها يعني
+
+840
+01:26:01,910 --> 01:26:07,230
+نسخة واحدة مصابة والثاني سليمة بتلاقيها بنتج على
+
+841
+01:26:07,230 --> 01:26:14,550
+أنه عندها المرض بينما الذكر لما يكون مصاب ماشي بس
+
+842
+01:26:14,550 --> 01:26:18,950
+ماعندهوش نسخة ثانية تكون سليمة يعني تمشيه فاللي
+
+843
+01:26:18,950 --> 01:26:24,330
+بيصير عنده زي هيك الـ Inheritance بيكون أنه الذكر
+
+844
+01:26:24,330 --> 01:26:30,800
+lethalيعني مافيش ذكر مصاب بهذا المرض اللي لما
+
+845
+01:26:30,800 --> 01:26:37,060
+يطلعوا بهذا الشكل بيكونوا high autism X-linked
+
+846
+01:26:37,060 --> 01:26:42,720
+dominant، ماشي؟ يعني هاي اللي انه ال females كلها
+
+847
+01:26:42,720 --> 01:26:49,040
+مصابات مش carriers، ماشي؟ مع أنه عندها one copy بس
+
+848
+01:26:49,040 --> 01:26:55,360
+مصابة وال .. وال males وال females ال males كلهم
+
+849
+01:26:55,360 --> 01:27:01,390
+الموجودينفيش حد مصاب، ماشي؟ وبالتالي يعني كلهم
+
+850
+01:27:01,390 --> 01:27:07,750
+لازم يكونوا normal، واضحة؟ تمام، الـ Homework اللي
+
+851
+01:27:07,750 --> 01:27:12,130
+حصلت عليها اليوم ال assignment كل قليل القصة و
+
+852
+01:27:12,130 --> 01:27:14,910
+لحاله يعني الـA لحاله، الـB لحاله، الـC لحاله،
+
+853
+01:27:14,910 --> 01:27:17,770
+الـD لحاله، الـE لحاله يعني هي الموضوع أعقد من
+
+854
+01:27:17,770 --> 01:27:24,420
+الطبيعي، ماشي؟الـ «A» والـ «B» بدنا نفصلهم عن بعض،
+
+855
+01:27:24,420 --> 01:27:31,580
+بدك تتأكد بالرياضيات إنه الفصل بالمعادلة سليم، آه
+
+856
+01:27:31,580 --> 01:27:36,220
+«A» هياخد مثلا اللي هو الـ «B» ورمز «B» والـ «A»
+
+857
+01:27:36,220 --> 01:27:42,240
+والـ «S» هو اللي هياخد الـ «Q»، صحيح؟ الـ «B» اللي
+
+858
+01:27:42,240 --> 01:27:46,300
+هو راح يكون الـ «A» والـ «B» مع بعض، بدك تحسبها
+
+859
+01:27:46,300 --> 01:27:54,400
+هيك، ماشي؟والـ AB هو الـ Heterozygous ماشي؟ يعني
+
+860
+01:27:54,400 --> 01:28:00,040
+تجربها و بيخليها للمرة الجاية بنحلنا كلها و بنشوف
+
+861
+01:28:00,040 --> 01:28:03,220
+شو بيطلع معاكم و أنا بقولكم شو النتيجة و بنشوف شو
+
+862
+01:28:03,220 --> 01:28:08,140
+بيطلع معايا أنا كمان خليني أشوفها يعني أسهل إشي
+
+863
+01:28:08,140 --> 01:28:15,560
+للـ O أسهل إشي للـ O لأن أنا Recessive
+
+864
+01:28:15,560 --> 01:28:21,910
+أه طيبالله يحضرك اللي هيطلع يعني لكل نسبتين
+
+865
+01:28:21,910 --> 01:28:30,830
+نسبتين؟ أه يحضر اللي هيطلع لكل قليل نسبتين لأ كيف
+
+866
+01:28:30,830 --> 01:28:35,150
+لكل قليل نسبتين الـ O بدك تطلع لكل قليل نسبتين
+
+867
+01:28:35,150 --> 01:28:42,610
+وبعدين تحسب لـ A و لـ B تفصلهم عن بعض هو الـ code
+
+868
+01:28:42,610 --> 01:28:46,110
+of general الـ S4 و الـ B4 نعم
+
+869
+01:28:50,210 --> 01:28:58,450
+مافيش a small و b small فاهم عليك؟ في a و o دول ال
+
+870
+01:28:58,450 --> 01:29:02,590
+capital A و small a هيك بدك تاخدهم و ال capital B
+
+871
+01:29:02,590 --> 01:29:11,130
+و small بيه مش small بيه فيه o ماشي بدك تجربها
+
+872
+01:29:11,130 --> 01:29:15,950
+شوفها ماشي الله يعطيكم العافية يعطيك ألف عافية
+
+873
+01:29:15,950 --> 01:29:21,560
+دكتورالله يرضى عليك جمال بدك الأسئلة على ال word
+
+874
+01:29:21,560 --> 01:29:25,260
+صح؟ وكل واحدة عليها الإجابة ان شاء الله رب
+
+875
+01:29:25,260 --> 01:29:29,480
+العالمين لسه شغال عليها و بس أخلص و أبعتلك إياها
+
+876
+01:29:29,480 --> 01:29:41,640
+تمام يا عزيزي يا عزيزي الله يسهل
+
+877
+01:29:41,640 --> 01:29:44,540
+الله يسهل الله يسهل الله يسهل الله يسهل الله يسهل
+
+878
+01:29:44,540 --> 01:29:46,360
+الله يسهل الله يسهل الله يسهل الله يسهل الله يسهل
+
+879
+01:29:46,360 --> 01:29:47,080
+الله يسهل الله يسهل الله يسهل الله يسهلالعزيزي
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/td1N2Fp6EAU.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/td1N2Fp6EAU.srt
new file mode 100644
index 0000000000000000000000000000000000000000..ef1d37fd90ad6d588c4908344670625eb405e363
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/td1N2Fp6EAU.srt
@@ -0,0 +1,2787 @@
+1
+00:00:00,000 --> 00:00:02,400
+مرحبًا ورحمة الله وبركاته بسم الله الرحمن الرحيم
+
+2
+00:00:02,400 --> 00:00:10,300
+دائمًا ما نحكي إنه في بداية أي محاضرة إذا أحد عنده
+
+3
+00:00:10,300 --> 00:00:15,520
+استفسار عن ما تم ذكره أو شرحه من قبل أو ما تم
+
+4
+00:00:15,520 --> 00:00:19,780
+مناقشته
+
+5
+00:00:19,780 --> 00:00:23,300
+في المحاضرات السابقة ممكن  نبدأ، نسأل يعني قبل
+
+6
+00:00:23,300 --> 00:00:28,060
+أن نبدأ المحاضرة، المحاضرة
+
+7
+00:00:28,060 --> 00:00:39,140
+اليوم هو الفصل الثالث عشر من الكتاب، حقيقةً يعني فيه
+
+8
+00:00:39,140 --> 00:00:50,740
+معلومات صعبة، فيها أن بعضها عبارة عن علاجات وطرق
+
+9
+00:00:50,740 --> 00:00:58,020
+علاج يعني نسميها تجريبية، فبالتالي الـ
+
+10
+00:00:58,930 --> 00:01:06,030
+الذي قد لا تكون كلها من الأشياء المثبتة المعتمدة
+
+11
+00:01:06,030 --> 00:01:16,030
+الـapproved  ويمكن استخدامها،  لكن ليس غلط أن الواحد
+
+12
+00:01:16,030 --> 00:01:23,470
+ينتبه لمستويات علاجات ومعالجة الأمراض الوراثية
+
+13
+00:01:23,470 --> 00:01:27,050
+بالنسبة
+
+14
+00:01:27,050 --> 00:01:34,470
+لِمحاضرة اليوم، أنا أظن يعني من أهم الأشياء التي
+
+15
+00:01:34,470 --> 00:01:43,630
+تعطينا هيكلة للعلاجات الممكنة، بيظل العلاج
+
+16
+00:01:43,630 --> 00:01:52,350
+الأخير في الأسفل، وهو العلاج على مستوى العائلة، الـ
+
+17
+00:01:52,350 --> 00:01:55,750
+Genetic Counseling، الـ Carrier Screening، الـ Pre-
+
+18
+00:01:55,750 --> 00:02:01,970
+Symptomatic Diagnosis، مبادئ من طرق
+
+19
+00:02:01,970 --> 00:02:07,870
+العلاج التي أحيانًا تتفاوت حسب الحالة وحسب المرض
+
+20
+00:02:07,870 --> 00:02:16,190
+وسيكون هناك إن شاء الله فصل لاحق في هذا المبحث
+
+21
+00:02:16,190 --> 00:02:22,450
+عن آليات وكيفية عمل الـGenetic Counseling، ما هي
+
+22
+00:02:22,450 --> 00:02:28,740
+مبادئه، وكيف نفعل ذلك، وماذا نفعل فيه، والأشياء هذه. إذا
+
+23
+00:02:28,740 --> 00:02:36,280
+افترضنا أن الأمراض التي ناتجة عن خلل في الجينات
+
+24
+00:02:36,280 --> 00:02:43,620
+في النهاية ستظهر بروتين معين، لأن الجين هو الشفرة
+
+25
+00:02:43,620 --> 00:02:50,200
+الوراثية لبروتينات معينة، وبالتالي ستكون المحصلة هي
+
+26
+00:02:50,200 --> 00:02:56,890
+إنتاج بروتين معين. مستويات العلاجات أو مستويات أنواع
+
+27
+00:02:56,890 --> 00:03:05,850
+التدخلات الممكنة، ممكن أن نقوم بتعديل نفس الجين
+
+28
+00:03:05,850 --> 00:03:16,520
+المصاب،  طبعاً هذه قضية كبيرة جداً وهناك
+
+29
+00:03:16,520 --> 00:03:21,760
+صعوبة بالغة في تعديل الجين في أي إنسان، إذا ذكرنا أن هذه
+
+30
+00:03:21,760 --> 00:03:26,880
+الجينات والمادة الوراثية في كل الخلايا متشابهة
+
+31
+00:03:26,880 --> 00:03:32,580
+وأنها محددة من لحظة التكون والتخلق عند تلقيح
+
+32
+00:03:32,580 --> 00:03:39,550
+البويضة، فمن تلك اللحظة الأصل أن كل المادة الوراثية
+
+33
+00:03:39,550 --> 00:03:44,470
+في كل الخلايا ناتجة ومتشابهة، إلا إذا حصلت عملية
+
+34
+00:03:44,470 --> 00:03:56,010
+طفرات غير مخططة لها، فتحدث، فأحياناً نستطيع
+
+35
+00:03:56,010 --> 00:04:06,010
+أن نغير في الـSomatic Genotype، يعني في خلايا الجسم
+
+36
+00:04:06,010 --> 00:04:15,060
+بعد ذلك، ويعني هذه قضية تكون في حالات محددة، بقضية
+
+37
+00:04:15,060 --> 00:04:20,120
+نقل الأعضاء، مثلًا، أو أسهلها من هذه الناحية
+
+38
+00:04:20,120 --> 00:04:25,080
+هي قضية الأشياء الوراثية، عملية نقل النخاع العظمي
+
+39
+00:04:25,080 --> 00:04:29,080
+أو يمكن الـ Stem Cells، التي هي الخلايا الجذعية
+
+40
+00:04:29,080 --> 00:04:34,540
+بطريقة علاج، فيه هناك بعض الأمراض لا يمكن استخدام
+
+41
+00:04:34,540 --> 00:04:36,820
+هذا الأسلوب.
+
+42
+00:04:38,610 --> 00:04:45,550
+لأن هناك محاولات أخرى، يعني الإشكالية كيف تدخل
+
+43
+00:04:45,550 --> 00:04:52,270
+الـجين داخل النواة، داخل الخلية، في كل
+
+44
+00:04:52,270 --> 00:04:58,790
+خلية، يعني، فهي الأمر ليس سهلًا، فهناك محاولات أخرى
+
+45
+00:04:58,790 --> 00:05:08,470
+لإعطاء أدوية لتغيير الـجين expression، وهو نابع
+
+46
+00:05:08,470 --> 00:05:14,730
+يعني كمثال أيضًا من الـ Sickle Cell باستخدام دواء
+
+47
+00:05:14,730 --> 00:05:21,490
+الذي هو Decitabine، ولحد
+
+48
+00:05:21,490 --> 00:05:27,010
+الآن يعني هو تجريبي، الكلام قديم قليلًا في الكتاب
+
+49
+00:05:27,010 --> 00:05:33,890
+التابع لكم، ويمكن أن يصبح مقبولاً أكثر، نحاول بطريقة فهم
+
+50
+00:05:35,370 --> 00:05:40,390
+العوامل التي تتحكم في الجين، والجين
+
+51
+00:05:40,390 --> 00:05:49,910
+Expression، ممكن الواحد يصلح ويزيد من إفراز أو
+
+52
+00:05:49,910 --> 00:05:57,950
+تكوين جين معين، هناك محاولات
+
+53
+00:05:58,580 --> 00:06:04,320
+عن طريق أجزاء، التي هي الـ Mutant Messenger RNA
+
+54
+00:06:04,320 --> 00:06:08,000
+لأن
+
+55
+00:06:08,000 --> 00:06:11,760
+نكون بتدخل
+
+56
+00:06:11,760 --> 00:06:18,080
+وبتحطيم بروتين نحن لا نرغب فيه، مثل الـ Amyloidosis
+
+57
+00:06:18,080 --> 00:06:21,640
+كمرض.
+
+58
+00:06:21,640 --> 00:06:28,500
+يعني سواءً مرات أنواع منه، الـ Amyloid deposits مثلًا
+
+59
+00:06:28,500 --> 00:06:33,440
+في الـ Alzheimer أو في مثلًا نفس الـ Classical
+
+60
+00:06:33,440 --> 00:06:38,220
+Amyloidosis، الـ Amyloidosis، هذا مرات راح نحكي عنه
+
+61
+00:06:38,220 --> 00:06:47,710
+أحيانًا نقوم بالـ Protein Replacement، يعني أنه ماشي
+
+62
+00:06:47,710 --> 00:06:53,950
+هذا الإنسان عنده بروتين ناقص، أنا أعطي مثلًا واحد
+
+63
+00:06:53,950 --> 00:06:58,470
+عنده Hemophilia أو نقص factor A، بُسير بشكل عند
+
+64
+00:06:58,470 --> 00:07:03,850
+الاحتياج أو بشكل متكرر، أعطي Cryoprecipitate أو
+
+65
+00:07:03,850 --> 00:07:09,690
+أعطي Recombinant factor A أو كذلك، أو مثلًا زي حالات
+
+66
+00:07:09,690 --> 00:07:13,670
+مرض الـ Gaucher، الذي هو من الـ Metabolic Diseases
+
+67
+00:07:14,210 --> 00:07:21,550
+بيكون فيه نقص إنزيم معين، «Glucocerebrosidase»
+
+68
+00:07:21,550 --> 00:07:27,090
+بصير نعطيها، بلاحظ أنه بيفيد وبحسن وكذا، أحيانًا
+
+69
+00:07:27,090 --> 00:07:32,090
+التأثير على الـ Mutant Protein بتغيير أو بتعويض أو
+
+70
+00:07:32,090 --> 00:07:41,830
+بتداخل مع، إعطاء الـ، إذا كان من المشاكل أن وظيفة
+
+71
+00:07:41,830 --> 00:07:46,970
+البروتين صارت أضعف، نعطيه شيء يخلي وظيفة البروتين
+
+72
+00:07:46,970 --> 00:07:51,630
+هذا أقوى وأحسن، ونحسنها، فالـ Pyridoxine في classic
+
+73
+00:07:51,630 --> 00:08:01,250
+Homocystinuria بيكون تحسين، يعني الآن عن طريق فهمنا
+
+74
+00:08:01,250 --> 00:08:02,810
+لـ
+
+75
+00:08:06,170 --> 00:08:12,510
+آلية المرض، مثلًا مثلًا الـ Phenylketonuria، ومعرفة
+
+76
+00:08:12,510 --> 00:08:16,110
+العامل المسبب للأعراض، مثلًا مثلًا مثلًا الـ
+
+77
+00:08:16,110 --> 00:08:22,090
+Phenylalanine، في هذه الحالة ممكن أنا أطلب
+
+78
+00:08:22,090 --> 00:08:27,330
+أن نغير الحمية تبع الإنسان، هذا الـ Dietary
+
+79
+00:08:27,330 --> 00:08:31,370
+Intervention، بحيث أن نعطيه  لو Phenylalanine،  ديات
+
+80
+00:08:31,370 --> 00:08:34,910
+أو لو بروتين، ديات بشكل عام، بالذات إذا فيه بروتين
+
+81
+00:08:35,920 --> 00:08:41,420
+عالي بـ Phenylalanine، حيث أن نمنع أعراض تبعات
+
+82
+00:08:41,420 --> 00:08:45,380
+المرض، ما نتدخل في البروتين، ما نتدخل في الجين على
+
+83
+00:08:45,380 --> 00:08:50,760
+مستوى الـ Metabolic Metabolism أو على مستوى نفس
+
+84
+00:08:50,760 --> 00:08:56,600
+الآلية
+
+85
+00:08:56,600 --> 00:09:02,100
+تبع التسبب بالمرض، نستخدمها في علاجه، في
+
+86
+00:09:02,100 --> 00:09:07,690
+الـUric Acid defects، مثلًا، الـ Sodium Benzoate أيضًا
+
+87
+00:09:07,690 --> 00:09:15,490
+يغير ويعدل في آليات التسبب
+
+88
+00:09:15,490 --> 00:09:24,290
+بالمرض، والـ Pathogenesis، أحيانًا ندخل لتخفيف مظهر
+
+89
+00:09:24,290 --> 00:09:27,610
+المرض، مثلًا الذي عنده ثلاسيميا أو Sickle Cell، أُصبح
+
+90
+00:09:27,610 --> 00:09:33,910
+أعطي Blood Transfusion، مثلًا Surgical Intervention،
+
+91
+00:09:33,910 --> 00:09:37,290
+مثلًا Correction of Congenital Heart Disease، إذا
+
+92
+00:09:37,290 --> 00:09:45,330
+كان مرض نتيجته أن فيه مثلًا خلل خلقي أو عيب خلقي
+
+93
+00:09:45,330 --> 00:09:51,770
+في القلب، أُدخل،  يعني الذي يجب أن يتذكره الواحد
+
+94
+00:09:51,770 --> 00:09:59,570
+أن أحيانًا قد يكون عندي آليات، طبعًا كل
+
+95
+00:09:59,570 --> 00:10:05,190
+هذه التدخلات
+
+96
+00:10:05,190 --> 00:10:12,890
+العلاجية بهذا الشكل تقوم على أساس، يجب أن يكون بعد
+
+97
+00:10:12,890 --> 00:10:18,610
+التفكير والتقدير والفهم
+
+98
+00:10:18,610 --> 00:10:26,070
+الـ Pathogenesis، يقوم الواحد بتطوير الدواء لتعطيل
+
+99
+00:10:26,070 --> 00:10:35,980
+أو تحسين جانب معين، فنعمل بعدين دراسات حول هذه الطرق
+
+100
+00:10:35,980 --> 00:10:43,000
+من العلاجات، و هذه طريقة العلاج نجحت
+
+101
+00:10:43,000 --> 00:10:50,440
+وأثبتت بشكل متكرر
+
+102
+00:10:50,440 --> 00:10:57,630
+الدراسة تحسين الوضع، فيصبح يعتمد، وينشر، ويناقش في
+
+103
+00:10:57,630 --> 00:11:03,930
+المؤتمرات، ويقيمها الخبراء، ويجربها الناس على مستوى أكبر
+
+104
+00:11:03,930 --> 00:11:11,470
+وأكبر وأكبر، وليس غلط أن الواحد يكون منتبهًا لهذه
+
+105
+00:11:11,470 --> 00:11:16,770
+الخيارات من العلاجات، حتى يشارك
+
+106
+00:11:16,770 --> 00:11:21,850
+في علاج كثير من الأمراض، كل واحد حسب خبرته، حسب ما
+
+107
+00:11:21,850 --> 00:11:28,490
+يرى، حسب يعني،  تحتاج  بشكل كبير مراكز متخصصة
+
+108
+00:11:28,490 --> 00:11:36,650
+تحتاج ناس عملت على هذه العلاجات، حتى تقيمها
+
+109
+00:11:36,650 --> 00:11:42,430
+الإنسان، و ترى درجة نجاحها، فـ
+
+110
+00:11:46,320 --> 00:11:55,740
+الدراسات تتفاوت،  أي الأشياء الممكن استخدامها، يعني
+
+111
+00:11:55,740 --> 00:12:04,360
+هذا هنا
+
+112
+00:12:04,360 --> 00:12:16,640
+ملخص مرة ثانية لأنواع العلاجات بشكل مجمل، هنا لأمراض
+
+113
+00:12:16,640 --> 00:12:27,860
+الوراثية، الـ Mendelian، وبقيم نسبة نوعية استفادة
+
+114
+00:12:27,860 --> 00:12:34,160
+الناس منها ضمن دراسة معينة في وقت معين، لا أعرف كم
+
+115
+00:12:34,160 --> 00:12:40,690
+مرض هنا، يعني العدد الكلي للأمراض التي تم تقييمها
+
+116
+00:12:40,690 --> 00:12:48,350
+ونسبة الاستفادة منها، ودرجة قبولها كطريقة
+
+117
+00:12:48,350 --> 00:12:55,810
+علاج، نتكلم في الـ Product Replacement مثلًا زي الدم
+
+118
+00:12:55,810 --> 00:13:00,690
+في حالة الثلاسيميا، Substrate Restriction مثلًا
+
+119
+00:13:00,690 --> 00:13:02,090
+الـ Dietary
+
+120
+00:13:04,440 --> 00:13:10,020
+مثلًا مثلًا الـ Phenylalanine والبروتينات، الـ Toxin Removal، الـ Coenzyme Supplementation، الـ
+
+121
+00:13:10,020 --> 00:13:13,540
+Inhibition of Toxic أو الـ Toxin Production أو الـ
+
+122
+00:13:13,540 --> 00:13:16,680
+Effect، الـ Enzyme Replacement Therapy، يعني لا أرى
+
+123
+00:13:16,680 --> 00:13:21,160
+أن فرق كثير عن رقم واحد، الخلايا التي ممكن
+
+124
+00:13:21,160 --> 00:13:28,380
+نفكر فيها. التعويض الـ gene في الإنسان المصاب، يتفاوت
+
+125
+00:13:28,380 --> 00:13:35,120
+بين Liver Transplantation، Bone Marrow Transplantation،
+
+126
+00:13:35,120 --> 00:13:39,000
+Kidney Transplantation،  بالمقارنة مع الـ Stem cell
+
+127
+00:13:39,000 --> 00:13:42,460
+في مرات كثيرة، يعني، هذه النسب
+
+128
+00:13:42,460 --> 00:13:51,940
+أظن ليس غلط أن الواحد يتطلع عليها،  ليس مفيدة  و هي دراسة في
+
+129
+00:13:51,940 --> 00:13:58,000
+لحظة معينة، على 57 مرض، هنا في حالة Inborn Errors of
+
+130
+00:13:58,000 --> 00:14:04,800
+Metabolism، يعني هذه Specifically مجموعة أمراض
+
+131
+00:14:04,800 --> 00:14:09,520
+التي فيها مشكلة في الميتابوليزم
+
+132
+00:14:09,520 --> 00:14:14,960
+وميتابوليتات،  المشروعات الموجودة في الشخص
+
+133
+00:14:14,960 --> 00:14:17,640
+ومتابوليتات المشروعات الموجودة في الشخص.
+
+134
+00:14:23,040 --> 00:14:28,860
+الفكرة أنه أيضًا يعني هكذا بشكل مجمل من دراسة محددة
+
+135
+00:14:28,860 --> 00:14:36,480
+نفسها التي عرضناها قبل قليل، أنها من سنة 1983
+
+136
+00:14:36,480 --> 00:14:44,980
+هناك 57 مرضًا و 31 حالة
+
+137
+00:14:44,980 --> 00:14:51,550
+أو مرضًا، يعني حتى العلاج الذي نحكي عنه نجد
+
+138
+00:14:51,550 --> 00:14:58,190
+فيه No Response، يعني الأفكار والطرق، والعلاجات كانت
+
+139
+00:14:58,190 --> 00:15:05,490
+مرتفع من 57، يعني أكثر من النصف بكثير كان فيه عدم
+
+140
+00:15:05,490 --> 00:15:14,850
+استجابة،  فيه 17%  استجابة بسيطة أو محدودة، على 9
+
+141
+00:15:14,850 --> 00:15:20,630
+على 9 أمراض، الاستجابة أقل، والنسبة عادةً أقل بكثير
+
+142
+00:15:20,630 --> 00:15:27,370
+لا يوجد Response، هذا الكلام سنة 83، كل ما نتقدم
+
+143
+00:15:27,370 --> 00:15:33,670
+بـ 93، وأخر دراسة بـ 2008،  فـ كلمة 2008
+
+144
+00:15:34,230 --> 00:15:38,970
+تقول أن هذه الدراسة قديمة جدًا، لأنه الآن يعني
+
+145
+00:15:38,970 --> 00:15:44,830
+عادةً خلال 12 سنة نجد تقدمًا أشد بكثير، ويمكن
+
+146
+00:15:44,830 --> 00:15:50,710
+كان سيعملون دراسة يكملون النتيجة، الفكرة أنهم
+
+147
+00:15:50,710 --> 00:15:57,210
+مع تقدم الوقت، وحتى الكلام لسنة 2008، النسب صارت بالعكس
+
+148
+00:15:57,210 --> 00:16:01,110
+يعني صار عندنا أمراض أكثر،  بأكثر من عشرين مرة
+
+149
+00:16:01,110 --> 00:16:07,590
+تقريبًا، نتوقع استجابة كاملة، يعني الفكرة أنه مع
+
+150
+00:16:07,590 --> 00:16:16,980
+فهم آلية المرض، والـ Mechanism تبعه، الجين تبعه،
+
+151
+00:16:16,980 --> 00:16:20,960
+الخلل كيف يكون في الجين، وتأثير الخلل على البروتين
+
+152
+00:16:20,960 --> 00:16:28,060
+وتأثير البروتين الوظيفي، كل هذا الفهم يعطينا مع
+
+153
+00:16:28,060 --> 00:16:38,080
+تقدم الطب والعلم والفهم أدوات أقوى،  لنحسن المرض
+
+154
+00:16:38,080 --> 00:16:43,960
+ونخفف آثاره، طبعًا يظل أن
+
+155
+00:16:43,960 --> 00:16:51,380
+نأخذها، كما حكينا في محاضرة لاحقة، قضية منع المرض،
+
+156
+00:16:51,380 --> 00:16:54,160
+الـ Prevention، يعني الـ Genetic Counseling،
+
+157
+00:16:54,160 --> 00:17:00,320
+الـ Family Planning، الـ Testing، الأشياء هذه التي
+
+158
+00:17:00,320 --> 00:17:06,060
+تساعد في منع المرض، حتى احتمالية حدوثه قبل
+
+159
+00:17:06,060 --> 00:17:09,440
+حدوثه، فهي مبادئ عامة.
+
+160
+00:17:17,690 --> 00:17:26,330
+أحيانًا الأنواع من الأمراض، إذا ثبتت، نتكلم عن أن
+
+161
+00:17:26,330 --> 00:17:33,830
+ممكن أحاول أعطي حتى الدواء في المرحلة الجنينية،
+
+162
+00:17:33,830 --> 00:17:41,500
+يعني الـ Prenatal، الـ Prenatal يعني في مرحلة جنينية
+
+163
+00:17:41,500 --> 00:17:54,660
+قبل الولادة، إذا ثبت تشخيص أو نتيجة حالات
+
+164
+00:17:54,660 --> 00:18:01,640
+سابقة مع فحص الحامل،
+
+165
+00:18:01,640 --> 00:18:09,140
+طبعاً هي وزوجها، وأحيانًا فحص جزء من الجنين عن طريق
+
+166
+00:18:11,280 --> 00:18:16,000
+بزل السائل الأمنيوسي، مثلًا الـ Sampling، أحيانًا يأخذ من الـ
+
+167
+00:18:16,000 --> 00:18:21,680
+مشيمة، أحيانًا يأخذ من الـ Amniotic Fluid، يضع
+
+168
+00:18:21,680 --> 00:18:27,620
+إبرة دقيقة جدًا في السائل حول الجنين، ويأخذ منه
+
+169
+00:18:27,620 --> 00:18:33,280
+عينة، وإذا عندك إمكانية فحص نوعي، يعني
+
+170
+00:18:33,280 --> 00:18:37,460
+الطفرة الوراثية المسببة للمرض، ممكن يكون عندك خيار
+
+171
+00:18:37,460 --> 00:18:41,490
+أن تعطي دواءً، أحيانًا هذه ظاهرة تحدث، أنك
+
+172
+00:18:41,490 --> 00:18:49,150
+تعطي الأم دواءً أو شيء يخفف المرض، يعني
+
+173
+00:18:49,150 --> 00:18:57,670
+أسرع أو  يقلل  المرض أو الحالة، ممكن يخفف منها
+
+174
+00:18:57,670 --> 00:19:02,700
+بالعلاج خلال الحمل، مثلًا الـ Folic Acid، هو
+
+175
+00:19:02,700 --> 00:19:08,200
+للـ Neural Tube Defect في الفتيات، يعني الـ Neural
+
+176
+00:19:08,200 --> 00:19:11,560
+Tube Defect،  الذي هو Neural Tube، أخذناه في الـ
+
+177
+00:19:11,560 --> 00:19:17,600
+Embryogenesis، أن الجهاز العصبي في الإنسان يتكون
+
+223
+00:23:49,680 --> 00:23:55,060
+الخلايا، فدول الناس بيسير بس يعني مثلاً ممكن يمر جنب
+
+224
+00:23:55,060 --> 00:24:02,080
+حبة الفول أو يمر يأكل فول أو بعض الأدوية مثلًا زي
+
+225
+00:24:02,080 --> 00:24:05,160
+الـ antimalarial drugs، الـ chloroquine أو الـ
+
+226
+00:24:05,160 --> 00:24:08,240
+hydroxychloroquine، أحيانًا الـ non-steroidal's
+
+227
+00:24:08,240 --> 00:24:13,080
+أنواع من الأدوية منتجة عنها المرض كله، فاللي بيصير
+
+228
+00:24:13,080 --> 00:24:18,500
+أنه مثل هؤلاء الأشخاص ما يجب أن نعطيه الـ
+
+229
+00:24:18,500 --> 00:24:23,600
+antimalarial drugs، حتى لو احتجنا الـ isoniazide
+
+230
+00:24:23,600 --> 00:24:29,380
+كمان فيه slow acetylators، فيه مثلًا side effect لـ
+
+231
+00:24:29,380 --> 00:24:32,880
+warfarin، ممكن أنا إذا بعرف واحد عنده certain
+
+232
+00:24:32,880 --> 00:24:38,570
+genetic mutation، مميع الـ warfarin ممنوع أعطيها الـ
+
+233
+00:24:38,570 --> 00:24:42,570
+Dietary Restriction، أشهر واحد الـ PKU اللي هو
+
+234
+00:24:42,570 --> 00:24:45,310
+الـ protein diet اللي هو الـ phenylalanine diet،
+
+235
+00:24:45,310 --> 00:24:50,970
+لازم تكون في ناس عندهم galactosemia، ليه
+
+236
+00:24:50,970 --> 00:24:58,790
+الـ increase in galactose، ماشي، الـ galactosemia،
+
+237
+00:24:58,790 --> 00:25:05,040
+أهـ .. يعني بدنا نمنع الـ galactose، بدنا الواحد
+
+238
+00:25:05,040 --> 00:25:09,480
+ماعندي فكرة كثير، مش كيف بتكون، بس بدنا الواحد يشوف
+
+239
+00:25:09,480 --> 00:25:15,920
+هذا السكر موجود في أنه مركبات، أنه أكلات الـBq
+
+240
+00:25:15,920 --> 00:25:21,780
+بالنسبة للفينيل ألانين يعني هو في غالب
+
+241
+00:25:21,780 --> 00:25:33,130
+البروتينات، مشتقات الأجبان، مشتقات الخبز، الذرة،
+
+242
+00:25:33,130 --> 00:25:39,610
+البطاطا، يعني الخبز والذرة، القمح والذرة ممنوعات
+
+243
+00:25:39,610 --> 00:25:46,870
+أظن أن البطاطا مسموحة، الرز مسموح، الرز العادي لأ
+
+244
+00:25:46,870 --> 00:25:50,850
+مش مسموح، يعني بتصير أكلات معينة مقبولة، وأشياء مش
+
+245
+00:25:50,850 --> 00:25:56,640
+مقبولة، وبدنا الواحد ينتبه، من الأكل، وين المادة
+
+246
+00:25:56,640 --> 00:26:01,840
+موجودة ولازم يبتعد عنها، أحيانًا بنعمل عملية
+
+247
+00:26:01,840 --> 00:26:10,860
+replacement، زي congenital hypothyroidism، هذه بنعطي
+
+248
+00:26:10,860 --> 00:26:15,640
+الـ، إذا كان جينيًّا ومعروف عنه، ممكن واحد يعطي الأم
+
+249
+00:26:15,640 --> 00:26:20,300
+إذا بقدر يدخل عليها، ما بعرف هنا، أما بعد الولادة،
+
+250
+00:26:20,300 --> 00:26:25,780
+إذا الطفل فيه ارتخاء، فيه تأخر في النمو، فيه جفاف،
+
+251
+00:26:25,780 --> 00:26:29,360
+لحتى يعني، وهذا بيؤثر على، لها مرض اسمه
+
+252
+00:26:29,360 --> 00:26:33,980
+"cretinism"، اللي هو يعني hypothyroidism في
+
+253
+00:26:33,980 --> 00:26:40,350
+الـ neonates وفي الأطفال، وله شكل معين، ويكون سهل
+
+254
+00:26:40,350 --> 00:26:45,190
+جدا علاجه إذا تم تشخيصه مبكرًا قبل ما يعمل تلف دائم
+
+255
+00:26:45,190 --> 00:26:54,610
+مثل الـ thyroxine، الـ "بيوتينيداز"
+
+256
+00:26:54,610 --> 00:26:57,770
+الـ "بيوتينيداز" الـ "بيوتينيداز" الـ
+
+257
+00:26:57,770 --> 00:26:57,870
+"بيوتينيداز" الـ "بيوتينيداز" الـ "بيوتينيداز"
+
+258
+00:26:57,870 --> 00:26:58,010
+"بيوتينيداز" الـ "بيوتينيداز" الـ "بيوتينيدناز"
+
+259
+00:26:58,010 --> 00:27:01,460
+الـ "بيوتينيداز" الـ "بيوتينيداز" الـ uric
+
+260
+00:27:01,460 --> 00:27:06,520
+acid disorders، حكينا الـ sodium benzoate، الفميليال
+
+261
+00:27:06,520 --> 00:27:12,820
+الـ hypercholesterolemia، الـ heterozygote زي اللي
+
+262
+00:27:12,820 --> 00:27:15,600
+هو الـ drugs that sequester bile acids in the
+
+263
+00:27:15,600 --> 00:27:20,620
+intestine، الليبيذز
+
+264
+00:27:20,620 --> 00:27:25,100
+الـ hypercholesterolemia، بدأ الـ bile acids عشان
+
+265
+00:27:25,100 --> 00:27:31,560
+يتم امتصاصها، فإذا يعني أضعفنا عملية الامتصاص الـ
+
+266
+00:27:31,560 --> 00:27:34,680
+hypercholesterolemia اللي بتأثر كثير على الشرايين
+
+267
+00:27:34,680 --> 00:27:42,060
+وبتعمل ترسب للدهون، وبتعمل تصلب الشرايين، بنوقفها،
+
+268
+00:27:42,060 --> 00:27:48,040
+بنساعد، نفس الفكرة لنفس المرض، ممكن نعطي statins،
+
+269
+00:27:48,040 --> 00:27:57,660
+برضه بتمنع المسبب في تكوين الكوليسترول، وزيادة الـ
+
+270
+00:27:57,660 --> 00:28:03,920
+level، تفعيل الـ receptor antagonism، "مارفان
+
+271
+00:28:03,920 --> 00:28:07,980
+سندروم"، الـ "لو سارطان"، investigational، أول مرة
+
+272
+00:28:07,980 --> 00:28:12,260
+بنتبه عليه، الـ "لو سارطان" هو دواء من أدوية الضغط
+
+273
+00:28:12,260 --> 00:28:18,680
+"بالسارطان"، "لو سارطان"، "كاندي سارطان"، هدول
+
+274
+00:28:18,680 --> 00:28:25,460
+مجموعة من أدوية الضغط بتقوم على تثبيت
+
+275
+00:28:29,240 --> 00:28:35,840
+اللي هو الـ ARBs، اللي هو angiotensin converting
+
+276
+00:28:35,840 --> 00:28:39,780
+enzyme، شبيهة في وظيفة الـ angiotensin converting
+
+277
+00:28:39,780 --> 00:28:46,120
+enzyme inhibitor، فالـ
+
+278
+00:28:46,120 --> 00:28:47,460
+losartan هذا
+
+279
+00:28:51,830 --> 00:28:58,230
+بيقوم بتنزيل الضغط، ويرفع البوتاسيوم كـ side
+
+280
+00:28:58,230 --> 00:29:02,350
+effect، له حقين أنه ممكن يستخدم في الـ Marfan
+
+281
+00:29:02,350 --> 00:29:13,910
+syndrome، يعني هذه برضه محاولات لتحسين
+
+282
+00:29:13,910 --> 00:29:15,990
+الوضع، هذا أحيانًا
+
+283
+00:29:18,040 --> 00:29:23,140
+يعني إنك أنت بالذات اللي عنده very high level of
+
+284
+00:29:23,140 --> 00:29:28,220
+lipids، بقول زي ما كنت حكيت مرة، لما واحد يسحب الدم
+
+285
+00:29:28,220 --> 00:29:35,960
+تبعه بيلاقي حليبي، يعني مشبع بالدهون درجة عالية جدًا
+
+286
+00:29:35,960 --> 00:29:41,860
+وهذا على المدى البعيد خطر جدًا، فحطينا أنه في بعض الـ
+
+287
+00:29:41,860 --> 00:29:47,380
+أتوقع لأي واحد يقول إن هذا علاج تجريبي لـ LDL
+
+288
+00:29:47,380 --> 00:29:52,320
+aphoresis، اللي هي الـ dialysis أو عملية غسيل الكلى
+
+289
+00:29:52,320 --> 00:29:57,940
+أو غسيل الدم أو كده، إن أنا آخذ دم الإنسان هذا
+
+290
+00:29:57,940 --> 00:30:05,910
+وأسحب منه الأشياء الضارة مثلًا، وأرجع له دمه مع ألبومين
+
+291
+00:30:05,910 --> 00:30:13,950
+سواء العادية أو بحيث أنه يقلل من مستوى الحالة أو
+
+292
+00:30:13,950 --> 00:30:21,090
+المرض، يعني أنا أظن أشياء كثيرة هنا الواحد بيتعلمها
+
+293
+00:30:21,090 --> 00:30:31,700
+وهذه أمثلة، في تفاوت بين قدرات الأدوية هذه، والنقطة
+
+294
+00:30:31,700 --> 00:30:37,420
+اللي ذكرناها أو يعني حطينا في
+
+295
+00:30:37,420 --> 00:30:43,000
+الـ "جرافات" اللي قبل، إنه فيه تطور، فيه تحسن بس
+
+296
+00:30:43,000 --> 00:30:49,120
+أحيانًا كثير من الأدوية حتى لما الواحد يجربها وحسب
+
+297
+00:30:49,120 --> 00:30:52,880
+ما بالدراسة بيقول أعطي الدواء لفلان، النسبة
+
+298
+00:30:52,880 --> 00:30:56,620
+الكبيرة منه، ممكن للواحد ما يلاقي أي استفادة، ممكن
+
+299
+00:30:56,620 --> 00:31:03,060
+استفادة بسيطة جدًا، والآن كل ما نتحسن أكثر في فهم
+
+300
+00:31:03,060 --> 00:31:06,340
+الآليات
+
+301
+00:31:06,340 --> 00:31:13,660
+للمرض، وبالتالي طرق عمل الأدوية، وبالتالي نزيد نسبة
+
+302
+00:31:13,660 --> 00:31:19,300
+الأشياء اللي بنعطيها أدوية بشكل عام، فهذه بعض
+
+303
+00:31:19,300 --> 00:31:20,160
+الأمثلة
+
+304
+00:31:25,110 --> 00:31:31,270
+بالنسبة للـ ammonia، بالنسبة للـ urea cycle defect
+
+305
+00:31:31,270 --> 00:31:36,830
+الـ sodium benzoate اللي هي يعني إنه الـ ammonia
+
+306
+00:31:36,830 --> 00:31:44,070
+بشكل يعني في
+
+307
+00:31:44,070 --> 00:31:49,460
+الإنسان الطبيعي، الـ protein catabolism للـ amino
+
+308
+00:31:49,460 --> 00:31:59,900
+acids، بدخل الـ NH3، المشي اللي هو الـ الـ الـ الـ
+
+309
+00:31:59,900 --> 00:32:06,300
+ammonia اللي هو toxic ومش كويس، وكذا، الأصل أن تروح
+
+310
+00:32:06,300 --> 00:32:08,820
+إلى شيء اسمه الـ urea cycle بحيث أنه بيطلع عند الـ
+
+311
+00:32:08,820 --> 00:32:15,680
+urea اللي بيطلع في الـ bowel، فهذا بيعمل يعني مشاكل
+
+312
+00:32:15,680 --> 00:32:21,500
+ممكن يعمل أظنّي stones، ممكن يعمل mental problem
+
+313
+00:32:21,500 --> 00:32:26,200
+ممكن يأثر على أشياء أخرى، ما شوفتش حالات ما بعرف
+
+314
+00:32:26,200 --> 00:32:33,160
+عنها، فيه عندنا شيء اسمه uricecle defect أو enzymes
+
+315
+00:32:33,160 --> 00:32:38,340
+أو problems، فإذا أعطيت حاجة اسمها sodium benzoate
+
+316
+00:32:39,050 --> 00:32:46,690
+سيحول مع الـ glycine والبنزوات، الـ urea، آسف، الأمونيا
+
+317
+00:32:46,690 --> 00:32:53,110
+ستتحول لـ hippurate، الـ hippurate هذا شيء ممكن يخرج في
+
+318
+00:32:53,110 --> 00:32:59,950
+الـ bowel، فبالتالي أنا أخفف المرض، وأمنع مشاكله، وأجد
+
+319
+00:32:59,950 --> 00:33:07,030
+آلية أخرى للجسم، وللـ "cell cycle" أو للجسم أنه
+
+320
+00:33:07,030 --> 00:33:12,150
+يخلص من الـ "toxic product" الـ "toxic product" اللي
+
+321
+00:33:12,150 --> 00:33:17,070
+بيكون very high بالنسبة لما يكون المرض موجود
+
+322
+00:33:17,070 --> 00:33:23,620
+ماشي، فهذا مثال على شيء نستفيد منه، بالنسبة
+
+323
+00:33:23,620 --> 00:33:28,780
+للـ familial hypercholesterolemia heterozygous، شكله
+
+324
+00:33:28,780 --> 00:33:32,920
+الـ homozygous بيكون شديد كثير وما بعيش أو كده أو
+
+325
+00:33:32,920 --> 00:33:36,280
+هيك، من
+
+326
+00:33:36,280 --> 00:33:38,740
+ناحية الأمراض هذه، اللي هو الـ familial
+
+327
+00:33:38,740 --> 00:33:45,940
+hypercholesterolemia heterozygous، بعد ما يعني
+
+328
+00:33:45,940 --> 00:33:56,210
+الـ LDL، low density lipoprotein، بتم أخذه بخلايا
+
+329
+00:33:56,210 --> 00:34:06,910
+الكبد، ناشي مع الـ HMG، هذا اللي هو الـ product تبع
+
+330
+00:34:06,910 --> 00:34:18,380
+اللي هو يعني المادة مع الـ coenzyme A بيكون الـ LDL
+
+331
+00:34:18,380 --> 00:34:22,940
+والمادة هذه بتتحول لكوليسترول، بيتم برضه إفرازه
+
+332
+00:34:22,940 --> 00:34:29,020
+ضمن الـ bile acid، وبرجع مرة ثانية، بدخل في الجسم
+
+333
+00:34:29,020 --> 00:34:35,180
+وبعدين محمول على LDL أو الكوليسترول بالذات، الـ low
+
+334
+00:34:35,180 --> 00:34:39,260
+density اللي هو الكوليسترول السيء، الـ high density
+
+335
+00:34:39,260 --> 00:34:43,930
+lipoprotein، الـ high-density lipoprotein لأ، كويس
+
+336
+00:34:43,930 --> 00:34:47,550
+وعلى أكس، protective، لو زاد، ما في مشكلة إذا كانت
+
+337
+00:34:47,550 --> 00:34:54,990
+زيادة منه، فإذا أنت أعطيت دواء أو شيء بيمنع امتصاص
+
+338
+00:34:54,990 --> 00:35:00,930
+الـ bile acid وهي الشيء المطلوب حتى يتم امتصاص الـ
+
+339
+00:35:00,930 --> 00:35:05,350
+lipids بشكل عام، الكوليسترول، الـ triglycerides، الـ
+
+340
+00:35:05,350 --> 00:35:09,970
+fatty acids، أي شيء من هذا النوع، بيحتاج الواحد لـ
+
+341
+00:35:10,320 --> 00:35:17,660
+bile acid حتى يتم الـ absorption، فإذا أنا أعطيت شيء
+
+342
+00:35:17,660 --> 00:35:24,160
+يوقف الـ absorption، بقلل الـ LDL اللي بوجود في
+
+343
+00:35:24,160 --> 00:35:31,980
+الجسم، وإذا حطيت برضه product that inhibit الـ
+
+344
+00:35:31,980 --> 00:35:36,180
+enzyme اللي بتؤدي لتقليل الـ synthesis برضه
+
+345
+00:35:36,180 --> 00:35:43,160
+للكوليسترول، في حالة ما يكون شديد كثير، برضه بتكون
+
+346
+00:35:43,160 --> 00:35:48,400
+آلية أخرى، يعني، فأحيانًا نحتاج أنه ننزل الـ LDL
+
+347
+00:35:48,400 --> 00:35:56,920
+وهذه أمثلة على نتيجة فهمنا للـ "ميكانيزم"
+
+348
+00:35:56,920 --> 00:36:01,980
+والـ "ميتابوليزم" والأشياء هذه، وكيف أنا أتدخل،
+
+349
+00:36:01,980 --> 00:36:06,160
+فإذا فيه "familial hypercholesterolemia heterozygous" الـ
+
+350
+00:36:06,160 --> 00:36:12,110
+"hyperlipidemia" من هذا النوع، familial، ولو دخل بالـ
+
+351
+00:36:12,110 --> 00:36:21,970
+premature death، ولو دخل إنه يكون فيه مشكلة هنا
+
+352
+00:36:21,970 --> 00:36:29,650
+نتكلم عن الـ Marfan syndrome، برضه حكينا على إن الـ
+
+353
+00:36:29,650 --> 00:36:34,210
+"لو سارطان" بيحاولوا إنه يستفيدوا منه حتى يعالجوا
+
+354
+00:36:34,210 --> 00:36:37,710
+هذه الحالة، ويعني
+
+355
+00:36:38,320 --> 00:36:46,800
+أول مرة بنتبه عليها، وما عندي خبرة كبيرة فيها، مارفان
+
+356
+00:36:46,800 --> 00:36:52,440
+سندروم، بالأخر كلها problem جينية، بيصير خلل في
+
+357
+00:36:52,440 --> 00:36:58,360
+المادة، والنسيج الضام، فبيصير صحيح الإنسان بيطلع طويل
+
+358
+00:36:58,360 --> 00:37:04,620
+كثير، بس معرض إنه يصير عنده subluxation، يعني
+
+359
+00:37:04,620 --> 00:37:11,520
+الأطراف مرنة كثير، بيصير الـ high-arch palate، بيصير
+
+360
+00:37:11,520 --> 00:37:15,880
+الـ lens dislocation في العيون، والـ congenital
+
+361
+00:37:15,880 --> 00:37:22,380
+يعني، أو الـ aortic aneurysm، الـ dilatation of the
+
+362
+00:37:22,380 --> 00:37:28,560
+abdominal aorta، كل هذه مظاهر، وشكله أنه يعني هذا
+
+363
+00:37:28,560 --> 00:37:34,240
+من استخدامات هذه الأدوية في يعني بقالية معينة يعني
+
+364
+00:37:36,890 --> 00:37:45,350
+الاستخدام هنا يعني حسب اللي يعني بدل واحد يكون
+
+365
+00:37:45,350 --> 00:37:54,270
+يأخذ أحدث معلومة على أحدث شيء متفق عليه، يعني
+
+366
+00:37:54,270 --> 00:38:04,610
+الأدوية من الأنواع الثانية، ماشي، بالنسبة
+
+367
+00:38:04,610 --> 00:38:12,170
+لـ… يعني زي
+
+368
+00:38:12,170 --> 00:38:23,790
+ما في عندنا فهم أكبر لخطوات تنشيط أي protein معين
+
+369
+00:38:23,790 --> 00:38:33,880
+يعني دائمًا نتكلم عن يعني غير الـ coding DNA تبع
+
+370
+00:38:33,880 --> 00:38:37,920
+الـ gene تبع الـ protein المعين اللي نتكلم عنه
+
+371
+00:38:37,920 --> 00:38:46,200
+أحيانًا يعني من خلال فهم خلق الإنسان، من خلال فهمنا
+
+372
+00:38:46,200 --> 00:38:50,920
+شو العوامل اللي بتخلي في الخلية هذه، هذا الـ gene
+
+373
+00:38:50,920 --> 00:38:55,960
+يشتغل، في الغالب راح يكون يعني اللي هو بيسموهم زي
+
+374
+00:38:55,960 --> 00:39:03,640
+growth factors، يعني signal
+
+375
+00:39:03,640 --> 00:39:09,840
+transduction mechanisms لتنشيط مواقع معينة في الـ
+
+376
+00:39:09,840 --> 00:39:18,120
+DNA، فلما يعرف الواحد الآليات هذه، ممكن يحسن قضية
+
+377
+00:39:18,120 --> 00:39:23,840
+علاجها بشكل متخصص، على إنه الأشياء اللي بدنا هيها
+
+378
+00:39:23,840 --> 00:39:29,740
+سواء نرغب إنه نزيد أو نقلل حسب المرض أو حسب الحالة
+
+379
+00:39:29,740 --> 00:39:35,800
+يعني إذا كان المنتج هو البروتين الفاسد المسبب للمرض
+
+380
+00:39:35,800 --> 00:39:41,440
+بدي لو فيه أقدر إنه المنشط لهذا البروتين أسكره
+
+381
+00:39:41,440 --> 00:39:49,440
+بكون خلصت المريض من هذا البروتين السيء، يعني فيه،
+
+382
+00:39:49,440 --> 00:39:54,660
+إذا بننتبه في حالة اسمها hereditary angioneurotic
+
+383
+00:39:54,660 --> 00:39:59,400
+edema أو hereditary angioedema، هذا من الأمراض اللي
+
+384
+00:39:59,400 --> 00:40:07,820
+أنا بتعامل معها، مرض نادر جدًا، عبارة عن حالة الإنسان
+
+385
+00:40:07,820 --> 00:40:14,340
+بيصير يطلع عليه يعني، وذمات وعائية زي ما بيقولوا
+
+386
+00:40:14,340 --> 00:40:19,520
+بالإنجليزي، angioedema، من الأمراض الشائعة جداً
+
+387
+00:40:19,520 --> 00:40:24,380
+الناس بيصير عندهم urticaria، angioedema، urticaria
+
+388
+00:40:24,380 --> 00:40:32,630
+اللي هي حالة يعني إن الإنسان بيكون عليه زي قرص
+
+389
+00:40:32,630 --> 00:40:39,850
+البعوض، طفح مزعج بسبب الحكة، زي قرص البعوض هذا
+
+390
+00:40:39,850 --> 00:40:44,490
+بنسميها "يوريتكاريا"، الـ "يوريتكاريا" شائعة جداً
+
+391
+00:40:44,490 --> 00:40:50,160
+ولها أسباب كثيرة، تحسس، ومرات أمراض كبد أو أمراض
+
+392
+00:40:50,160 --> 00:40:55,480
+غدة درقية أو أمراض كلية أو أمراض طفيليات أو
+
+393
+00:40:55,480 --> 00:40:59,560
+parasitic infection تعمل حساسية كذا، بس فيه نوعية
+
+394
+00:40:59,560 --> 00:41:07,400
+محددة عبارة عن حالة وراثية autosomal dominant،
+
+445
+00:45:57,850 --> 00:46:04,690
+Hemoglobin تبعه اللي عنده … اللي إذا كان مصاب بـ SS،
+
+446
+00:46:04,690 --> 00:46:10,070
+Sickle Cell Disease، ماشي؟ فيه Sickle Cell Carrier
+
+447
+00:46:10,070 --> 00:46:16,590
+SA، حتى المصابين لما نيجي نعمل حتى Protein
+
+448
+00:46:16,590 --> 00:46:20,910
+Electrophoresis أو Hemoglobin Electrophoresis
+
+449
+00:46:21,370 --> 00:46:25,910
+بنلاقي ممكن يعني لأنه في فترة في حياة الإنسان كان
+
+450
+00:46:25,910 --> 00:46:29,350
+عنده Hemoglobin-F، مش الـHemoglobin من هذا النوع
+
+451
+00:46:29,350 --> 00:46:38,110
+فالملاحظ أنه لو إنسان  زال عنده إنتاج للـHemoglobin
+
+452
+00:46:38,110 --> 00:46:45,130
+-F بنسبة أكبر، بيصير المرض أخف، والسبب أنه كل ما
+
+453
+00:46:45,130 --> 00:46:51,630
+ارتفعت كمية الـHemoglobin-F في خلايا الدم الحمراء
+
+454
+00:46:51,630 --> 00:46:56,350
+الـ Cycling Phenomena بتقل، ما بتحدث بنفس الطريقة
+
+455
+00:46:56,350 --> 00:47:02,050
+فبالتالي إذا حطينا
+
+456
+00:47:02,050 --> 00:47:09,510
+شيء بِدَلالة معينة، يعني زودنا نسبة الـ Hemoglobin F
+
+457
+00:47:09,510 --> 00:47:14,770
+طبعاً بدّه يكون Hemoglobin F جوا خلايا الدم
+
+458
+00:47:14,770 --> 00:47:22,740
+الحمراء، يعني لازم نتدخل أو بدَلالة معينة نصل إلى
+
+459
+00:47:22,740 --> 00:47:27,720
+نفس الخلايا المصابة ونحاول أن نغيّر فيها الـ
+
+460
+00:47:27,720 --> 00:47:31,520
+Hemoglobinopathies والـ Sickle Cells وكذا بشكل
+
+461
+00:47:31,520 --> 00:47:36,100
+عام، يعني بالذات إذا كان المكان متقدم طبياً فيه
+
+462
+00:47:36,100 --> 00:47:44,540
+وبالذات إذا شُخصت الحالة مبكراً وتم يعني
+
+463
+00:47:46,870 --> 00:47:50,710
+بالتفكير والتدخل، إذا كان هناك خبرة أو إمكانات أو
+
+464
+00:47:50,710 --> 00:47:58,060
+شيء آخر قبل أن يُعطى الإنسان نقل دم بشكل كبير، يعني
+
+465
+00:47:58,060 --> 00:48:03,620
+أول علاج سريع لما بتكون فيه أزمة و Crisis ومشاكل
+
+466
+00:48:03,620 --> 00:48:10,480
+أنه نعطي دم، بيحسن المريض عرضياً، بشكل أعراضه يعني
+
+467
+00:48:10,480 --> 00:48:13,960
+الـ Anemia بيخففها، الـ Sickle Cell Episode بيخففه
+
+468
+00:48:13,960 --> 00:48:20,320
+بيعمل تحسين للمريض يعني، فالنقل
+
+469
+00:48:20,320 --> 00:48:24,700
+للمخاع العظم، ماشي؟ للـ Thalassemia أو الـ
+
+470
+00:48:24,700 --> 00:48:30,730
+Hemoglobinopathies، واللي راح ناخد بعد شوية اللي هم
+
+471
+00:48:30,730 --> 00:48:36,770
+الأمراض نقصان المناعة الأولية، الـ Primary Immune
+
+472
+00:48:36,770 --> 00:48:40,330
+Deficiencies، زي الـ Severe Combined Immune
+
+473
+00:48:40,330 --> 00:48:45,950
+Deficiency، الـ SCID، هدول إذا الواحد بقدر يعمل
+
+474
+00:48:45,950 --> 00:48:49,250
+Bone Marrow Transplantation أو تمثل Transplantation من
+
+475
+00:48:49,250 --> 00:48:56,800
+إنسان قريب بكون كويس، بس أحياناً إذا تم إعطاء يعني
+
+476
+00:48:56,800 --> 00:49:01,620
+لما يكون فيه نقلة من شخص  عادة ما في مشكلة ما بنفش
+
+477
+00:49:01,620 --> 00:49:05,000
+داعي لدمة أو لا شيء محدد من قبل زاد إنه نفس
+
+478
+00:49:05,000 --> 00:49:09,500
+الإنسان، مناعته ضعيفة ما بتخليه يقدر يرفض العضو اللي
+
+479
+00:49:09,500 --> 00:49:12,520
+معطيه له، مش عارف؟ بس بالنسبة
+
+480
+00:49:12,520 --> 00:49:17,260
+للـHemoglobinopathies، إذا تم إعطاء الدم مرات كثيرة
+
+481
+00:49:17,260 --> 00:49:23,360
+إلا كل مرة بكون في بعض خلايا الدم البيضاء أو بعض
+
+482
+00:49:23,360 --> 00:49:31,780
+الـAntigens، زي مثال مثلًا حتى لو بشكل نادر، للـRare
+
+483
+00:49:31,780 --> 00:49:37,840
+Blood Groups، كأنه أعطانا إنسان زي ما بنعطي زي ما
+
+484
+00:49:37,840 --> 00:49:42,120
+يحصل مع المرأة الحامل بالـRH Incompatibility، إنه
+
+485
+00:49:42,120 --> 00:49:47,240
+يكون الجنين
+
+486
+00:49:47,240 --> 00:49:51,890
+الأول اللي أتلقاه Positive، بيكون الجنين الأول
+
+487
+00:49:51,890 --> 00:49:55,510
+بيعدي وما فيش مشكلة، بس بعدين لما يصير
+
+488
+00:49:55,510 --> 00:49:59,850
+الـSensitization، ما بيظل الجنين الثالث أو الرابع
+
+489
+00:49:59,850 --> 00:50:10,910
+بيصير يتجهد كل ما يتم حمل، يعني فالفكرة أنه إذا بدنا
+
+490
+00:50:10,910 --> 00:50:16,930
+نقل نخاع عظم لـ هذه المشكلة اللي هي الـHemoglobin
+
+491
+00:50:16,930 --> 00:50:22,070
+opathies، لازم يعمل بشكل مبكر، لازم يعمل قبل ما يُعطى
+
+492
+00:50:22,070 --> 00:50:27,530
+المريض عدد كبير من نقل الدم، ويقال عليه عملية
+
+493
+00:50:27,530 --> 00:50:31,890
+الـAlloimmunization، بيصير المناعة منشطة كثير
+
+494
+00:50:31,890 --> 00:50:37,050
+بحيث أنها ترفض نقل الدم، وبالتالي تصير مشاكل، فبديل
+
+495
+00:50:37,050 --> 00:50:41,450
+آخر لما ما يكون عنده إمكانية لهذا النوع من العلاج
+
+496
+00:50:41,450 --> 00:50:49,340
+الأكثر أنه أنا أعدل درجة الـDNA methylation، بدواء
+
+497
+00:50:49,340 --> 00:50:53,040
+مثل ديستابين
+
+498
+00:50:53,040 --> 00:50:58,380
+لزيادة الـ hemoglobin F، اللي بيحسن الـ Sickle Cell
+
+499
+00:50:58,380 --> 00:51:05,900
+على الأقل مظهرياً، مع اللي إذا بننتبه للسهم الرابع
+
+500
+00:51:05,900 --> 00:51:10,640
+اللي هو الـ Gene Therapy، زي الـ X-Linked Severe
+
+501
+00:51:10,640 --> 00:51:13,760
+Combined Immune Deficiency، زي اللي هو الـ
+
+502
+00:51:13,760 --> 00:51:18,960
+Adenosine Deaminase Deficiency، أحيانًا إذا في نقص
+
+503
+00:51:18,960 --> 00:51:26,700
+إنزيم معين، بالذات في قضية نقل النخاع العظم فهو من
+
+504
+00:51:26,700 --> 00:51:35,620
+ناحية تقنية، من ناحية procedure، خفيف وبسيط وسهل جداً
+
+505
+00:51:35,620 --> 00:51:41,200
+يعني ما فيه تعقيدات كثيرة، يعني يُنقل في جسم المصاب
+
+506
+00:51:41,200 --> 00:51:45,680
+عن طريق نقل الدم، يعني هيك زي نقل الدم، لما أنقل أنا
+
+507
+00:51:45,680 --> 00:51:52,640
+نخاع عظم، نخاع العظم من المتبرع، بنيجي وبنخدره
+
+508
+00:51:52,640 --> 00:51:57,540
+وبنيجي على العظام الكبيرة، فيه عظام الحوض مثلاً
+
+509
+00:51:57,910 --> 00:52:04,690
+بالذات، بإبر كبيرة، كثير مرات، بنسحب نخاع العظم
+
+510
+00:52:04,690 --> 00:52:08,550
+من الإنسان الطبيعي، فبتطلع لنا كمية بتكون شبيهة
+
+511
+00:52:08,550 --> 00:52:14,510
+بوحدة الدم، بحيث إنه نقلها للإنسان المصاب بكون عن
+
+512
+00:52:14,510 --> 00:52:20,490
+طريق نقل دم عادي، والخلايا الجذعية والخلايا النخاع
+
+513
+00:52:20,490 --> 00:52:24,370
+العظم بتعرف تنتقل، ترجع عن طريق الدم لنخاع العظم
+
+514
+00:52:24,370 --> 00:52:24,850
+تبعها
+
+515
+00:52:30,600 --> 00:52:39,060
+ففي آليات أخرى، زي إنه نعطي Small Inactive RNA
+
+516
+00:52:39,060 --> 00:52:45,980
+Segments، يعني عبارة عن إن أنا أعطي
+
+517
+00:52:45,980 --> 00:52:56,430
+شيء يؤثر على إنه يخرّب أو يقلل الـMessenger RNA، كل
+
+518
+00:52:56,430 --> 00:53:03,210
+المشاكل اللي يعني بذكر مرة ثانية، يعني في بعض
+
+519
+00:53:03,210 --> 00:53:09,230
+الأشياء أنا عندي خبرة فيها شوية، ويعني راح نتفرج
+
+520
+00:53:09,230 --> 00:53:13,550
+على كثير من الأشياء بعدين، بحط لك إياها على إنه
+
+521
+00:53:13,550 --> 00:53:18,170
+تجربة، قام وبيعملها، وكانت النتيجة نص نص، كويسة
+
+522
+00:53:18,170 --> 00:53:22,710
+كثير، كويسة بشكل واضح، كذا، وتلاقي شغلات عبارة عن
+
+523
+00:53:22,710 --> 00:53:27,920
+عمليات دراسية، الـ «Messenger RNA» جوا الخلية صعب أن
+
+524
+00:53:27,920 --> 00:53:35,300
+الواحد يغيره، وكانت تعطي، حتى لو ما بستطيعش أني مثلاً
+
+525
+00:53:35,300 --> 00:53:41,500
+أجيب حبة الدواء للمريض يأخذها، أو حتى إذا شيء صعب أنه
+
+526
+00:53:41,500 --> 00:53:47,740
+يكون عن طريق الفم، حتى عن طريق الوريد، لو دخّلته جوا
+
+527
+00:53:47,740 --> 00:53:57,340
+الجسم بشكل حقن أو بالوريد، ليس بالضرورة إنه يكون
+
+528
+00:53:57,340 --> 00:54:04,600
+مفيد إنه بدّك الدواء هذا يصل جوا الخلايا، لحيث إنه
+
+529
+00:54:04,600 --> 00:54:10,700
+يعني أو بالذات إذا الـMolecule كبير وComplex وكذا
+
+530
+00:54:10,700 --> 00:54:18,520
+الجسم بحكمته ما بيسمحله يدخل جوا الخلية، فقضية
+
+531
+00:54:18,520 --> 00:54:25,570
+زي الـTransthyretin، الـ Trans-thyretine في الـ
+
+532
+00:54:25,570 --> 00:54:34,390
+Amyloidosis، يعني نوع من استخدام الـ RNA لتعديل على
+
+533
+00:54:34,390 --> 00:54:37,550
+مستوى الـ expression أو الـ function of the
+
+534
+00:54:37,550 --> 00:54:43,930
+messenger RNA، أحياناً في
+
+535
+00:54:43,930 --> 00:54:52,820
+بعض الأدوية، لأنه لما يكون عندي أنا جزء من الـ الـ
+
+536
+00:54:52,820 --> 00:54:58,800
+Pathology، جزء من تسبب المرض، أنه الـ يعني زي ما
+
+537
+00:54:58,800 --> 00:55:03,220
+تقوله مثلاً، كيف الفرق بين الـ الـ Hemoglobin
+
+538
+00:55:03,220 --> 00:55:06,540
+العادي، الـ Beta Chain، والـ Sickle Beta Chain
+
+539
+00:55:06,540 --> 00:55:11,200
+في حالة الـ Sickle Cell Disease، أنه الـ Sickle
+
+540
+00:55:11,200 --> 00:55:17,160
+Cell Disease، الـ Mutant Protein، الـ Abnormal
+
+541
+00:55:17,160 --> 00:55:21,960
+Protein، فيه قُلوب ميزة بتخليه ما يشتغلش مظبوط
+
+542
+00:55:23,250 --> 00:55:26,990
+فمثلاً، شيء مكان المفروض يكون مفتوح، صار عندي
+
+543
+00:55:26,990 --> 00:55:32,650
+Folding بطريقة مختلفة، وسكر، فإذا عندي دواء أو شيء
+
+544
+00:55:32,650 --> 00:55:39,010
+بقدر أخلي المكان المفتوح يظل مفتوح وما يسكرش، ممكن
+
+545
+00:55:39,010 --> 00:55:50,750
+هذا يكون مفيد يعني، فهذا فيه دواء «Lumacaftor»، «Luma
+
+546
+00:55:50,750 --> 00:55:56,690
+caftor» اللي هو «Stabilizes Reformed» اللي هو
+
+547
+00:55:56,690 --> 00:56:05,210
+«ΔF508» في مرض معين يعني، فهي كلها أمثلة إلى
+
+548
+00:56:05,210 --> 00:56:10,090
+أدوية وأشياء، الـ Cystic Fibrosis، وهنا إحنا يعني
+
+549
+00:56:10,090 --> 00:56:12,550
+يمكن هيك كثير من الأمثلة بتيجي على الـ Cystic
+
+550
+00:56:12,550 --> 00:56:17,350
+Fibrosis، الممكن
+
+551
+00:56:17,350 --> 00:56:22,850
+أنا يعني أعطي أدوية تساعد الـ Protein Replacement
+
+552
+00:56:22,850 --> 00:56:26,950
+يعني بعد ما نوصل يعني ممكن الـ Folding، ممكن أنا
+
+553
+00:56:26,950 --> 00:56:33,570
+أعطي شيء يـMaintain it، البروتين اللي اتكون هذا
+
+554
+00:56:33,570 --> 00:56:37,930
+أحياناً بيكون معقد وفي أشياء كثيرة، وأنا مثال على
+
+555
+00:56:37,930 --> 00:56:42,470
+«سيستيك فايبروسيس»، «Cystic Fibrosis Transmembrane
+
+556
+00:56:42,470 --> 00:56:50,870
+Conductors Receptor»، وهو نقله أكثر من الـ «domain» وعبارة عن
+
+557
+00:56:50,870 --> 00:56:57,230
+«gate» للـ «ion exchange»، فبالتالي إذا أنا
+
+558
+00:56:57,230 --> 00:57:07,290
+لقيت أدوية بتحسن وظيفة الـ Protein هذا، ممكن أنا
+
+559
+00:57:07,290 --> 00:57:12,550
+مرض زي الـ Cystic Fibrosis أحسنه، الهيموفيليا بيكون
+
+560
+00:57:12,550 --> 00:57:15,290
+إنه أنا بعمل protein replacement with native
+
+561
+00:57:15,290 --> 00:57:21,370
+protein، زي هنا، أو إنه الـ Gaucher Disease أو
+
+562
+00:57:21,370 --> 00:57:25,500
+Fabry Disease، من الـ Metabolic Diseases
+
+563
+00:57:25,500 --> 00:57:30,340
+الـ ERT برضه ممكن أنا أعطيه بروتين، مرات مع أنه
+
+564
+00:57:30,340 --> 00:57:34,780
+المفروض يشتغل جوا خلايا، بس إذا بيعطيه بالدم ممكن
+
+565
+00:57:34,780 --> 00:57:40,540
+أحيانًا يحسن المرض، يعني بالحالة هذه أحياناً بنسوّي
+
+566
+00:57:40,540 --> 00:57:45,380
+الـ Replacement بـ Modified Protein، ماشي؟ الـ
+
+567
+00:57:45,380 --> 00:57:53,290
+Regulation، يعني الـ Big  هذه نسيت اختصار لإيش، في
+
+568
+00:57:53,290 --> 00:57:58,830
+أحياناً أدوية وحالات
+
+569
+00:57:58,830 --> 00:58:05,870
+مثلاً في الكثير، مثلاً التهاب الكبد الوبائي الـ C
+
+570
+00:58:05,870 --> 00:58:11,730
+اللي بتاعته الـ C فيروس، وإلا عندي أنا مثلاً chronic
+
+571
+00:58:11,730 --> 00:58:15,590
+granulomatous disease، أو في حالات عندي زي الـ
+
+572
+00:58:15,590 --> 00:58:20,550
+Natural Killer Cell Deficiency، «طبيعي قاتل الخلايا» في من
+
+573
+00:58:20,550 --> 00:58:26,250
+الأدوية، دواء عبارة عن هرمون في المناعة تفرزه الجسم
+
+574
+00:58:26,250 --> 00:58:29,150
+في مرحلة معينة، في مقاومة الفيروسات، اسمه الـ
+
+575
+00:58:29,150 --> 00:58:35,830
+Interferon، فالـ Interferon الطبيعي
+
+576
+00:58:35,830 --> 00:58:39,890
+اللي أول ما صنعوه، لما
+
+577
+00:58:42,220 --> 00:58:46,720
+بأعطيه في جسم الإنسان، بأعطيه حقنة للإنسان هذا
+
+578
+00:58:46,720 --> 00:58:53,300
+ميزته صحيح، مؤثر وبيعمل  Feel، بس بِيرتفع كثير وبيختفي
+
+579
+00:58:53,300 --> 00:58:57,800
+بسرعة، فبيتم يعني الـ «metabolism» و الـ «half-life»
+
+580
+00:58:57,800 --> 00:59:04,620
+تبع الدواء أو تبع الهرمون هذا سريع كثير، فعملية الـ
+
+581
+00:59:04,620 --> 00:59:11,310
+«pegylation»، عملية الـ «peg interferon»، هي عبارة عن
+
+582
+00:59:11,310 --> 00:59:18,330
+إضافة مركب آخر على الـ Interferon، بحيث أنه بيطول
+
+583
+00:59:18,330 --> 00:59:22,550
+عمره، وبيخلّي الـ Half-Life أطول، وبيخلّي تأثير
+
+584
+00:59:22,550 --> 00:59:27,010
+الدواء يستمر لمدة أطول، فعملية الـ Pegylation هي
+
+585
+00:59:27,010 --> 00:59:31,190
+عبارة عن Modification للبروتين التابع للدواء
+
+586
+00:59:31,190 --> 00:59:38,430
+وأحياناً بنستفيد منها في خاصية هذه، إنه بتخلّي الـ
+
+587
+00:59:39,150 --> 00:59:43,130
+الـ Enzyme أو الـ «هرمون» أو الـ «دواء» اللي
+
+588
+00:59:43,130 --> 00:59:49,590
+مطلوب، بتخلّي مدته في الجسم طويلة، ففي حالات الـ ADA
+
+589
+00:59:49,590 --> 00:59:53,470
+Deficiency، اللي هو الـ «أدينوسين دِياميناس»
+
+590
+00:59:53,470 --> 00:59:57,950
+الـEnzyme، اللي في حالات الـSevere Combined Immune
+
+591
+00:59:57,950 --> 01:00:04,610
+Deficiency، الحالات اللي هي نقص المناعة الـ
+
+592
+01:00:06,240 --> 01:00:09,880
+للـ T و الـ B-cells، يعني الـ Combined، الـ Both
+
+593
+01:00:09,880 --> 01:00:17,160
+خلايا المناعة المكتسبة أو المناعة المتخصصة اللي هم
+
+594
+01:00:17,160 --> 01:00:20,440
+الـ T و الـ B-Lymphocytes، الاثنين هم بيكونوا قليلين
+
+595
+01:00:20,440 --> 01:00:27,580
+ومش شغالين، وبيصير عندنا أمراض كثيرة، فهذه لما أنا
+
+596
+01:00:27,580 --> 01:00:36,240
+أعطي الـ Peg ADA، ممكن أنه يحسّن الوضع، ما عندي خبرة في
+
+597
+01:00:36,240 --> 01:00:43,680
+الحالات هذه، يعني الـSCID، أنا بعرف أنه أهم شيء لهم
+
+598
+01:00:43,680 --> 01:00:49,620
+لما يكون فيه تشخيص مبكر، أنه يتم عملية نقل نخاع
+
+599
+01:00:49,620 --> 01:00:56,670
+العظم من شخص قريب، بشكل مفيد، وراح نحكي عن آليات أخرى
+
+600
+01:00:56,670 --> 01:01:03,770
+إذا ما توفّر donor كويس، ممكن الواحد يعني يأخذ الـ
+
+601
+01:01:03,770 --> 01:01:08,010
+Bone Marrow تبعه، أو خلايا نفس المريض، عدّلها جينياً في
+
+602
+01:01:08,010 --> 01:01:12,370
+المختبر، ويرجعها له هي مرة ثانية، يعني قضية الـ
+
+603
+01:01:12,370 --> 01:01:15,710
+Bone Marrow، للآن الـ Hemoglobinopathies
+
+604
+01:01:17,880 --> 01:01:21,220
+و الـ Immune Deficiencies، الـ Primary Immune
+
+605
+01:01:21,220 --> 01:01:25,980
+Deficiencies، هي الأشياء اللي يعني مقبولة ومعروفة
+
+606
+01:01:25,980 --> 01:01:33,500
+أنها بتوفر وبتفيد وكويسة، الـ Other types of
+
+607
+01:01:33,500 --> 01:01:38,700
+disease treatment، اللي هو زي الـ Cofactor أو زي
+
+608
+01:01:38,700 --> 01:01:43,320
+الـ Vitamin B6، اللي هو في Cystinuria بتكون برضه ممكن
+
+609
+01:01:43,320 --> 01:01:49,710
+أستفيد منها، فهذه أمثلة لـ Molecular Treatments لـ
+
+610
+01:01:49,710 --> 01:01:55,750
+Genetic Diseases، وهي بعض الآليات والأفكار بالنسبة
+
+611
+01:01:55,750 --> 01:02:01,110
+للعلاجات، هو أنا بدي أثبت إنه دراسة معينة على حالة
+
+612
+01:02:01,110 --> 01:02:10,050
+معينة، لما أعطوا الدواء هذا، هنا دراسة تعتبر نسبياً
+
+613
+01:02:10,050 --> 01:02:18,280
+كبيرة، على 83 حالة،  ظلّ منهم 77 حالة، كيف أنه يعني
+
+614
+01:02:18,280 --> 01:02:23,620
+في مقابل 70 حالة ما أخذوش الدواء أو أخذوا المادة
+
+615
+01:02:23,620 --> 01:02:30,480
+الخاملة شوية، سكر اللي هو Ivacaftor
+
+616
+01:02:30,480 --> 01:02:37,
+
+667
+01:07:21,290 --> 01:07:26,050
+Deficiency وهي معلومة ما كنتُ أعرفها
+
+668
+01:07:26,050 --> 01:07:34,340
+كثيرًا ما يُستخدم هذا الدواء بهذه الطريقة مؤقتًا
+
+669
+01:07:34,340 --> 01:07:38,080
+لتحسين
+
+670
+01:07:38,080 --> 01:07:42,000
+وضع المريض حتى يتحمل الـHLA-Bomber
+
+671
+01:07:42,000 --> 01:07:49,860
+Transplantation يعني مفيد مؤقتًا، عبارة عن نسق
+
+672
+01:07:49,860 --> 01:07:56,240
+لعملية نقل نخاع العظم بعدها لهذه الحالة الـ
+
+673
+01:07:56,240 --> 01:07:58,600
+Gaucher Disease
+
+674
+01:08:01,020 --> 01:08:06,440
+يعني هو من الأمراض التي تصيب الجهاز العصبي أيضًا
+
+675
+01:08:06,440 --> 01:08:13,480
+Beta-Glucosidase Deficiency فأنا أعوّض الـ
+
+676
+01:08:13,480 --> 01:08:18,860
+Protein هذا، يعني أظن أنه مطلوب، لم يُذكر في الـ
+
+677
+01:08:18,860 --> 01:08:26,360
+HLA-Bomber ولا في الـ... يعني مطلوب أن يكون في الـNervous
+
+678
+01:08:26,360 --> 01:08:30,860
+system أو يكفي الكبد، لأن الكبد هو الأهم للـ
+
+679
+01:08:30,860 --> 01:08:38,340
+metabolism بشكل عام، يعني فأحيانًا يكون إذا
+
+680
+01:08:38,340 --> 01:08:47,180
+كان أحد يعرف، مثل الإكحالات، أنه ممكن أن يكون
+
+681
+01:08:47,180 --> 01:08:52,190
+هي نوع من الأدوية المفيدة، أحيانًا أعدّل في وظيفة
+
+682
+01:08:52,190 --> 01:09:18,970
+الـ…
+
+683
+01:09:19,250 --> 01:09:24,390
+يتكوّن الإنزيم الكامل، فأحيانًا إذا كان عندي
+
+684
+01:09:24,390 --> 01:09:29,510
+mutation بحيث يكون على المستوى العادي من
+
+685
+01:09:29,510 --> 01:09:36,890
+vitamin cofactor، يكون إن نسبة الإنزيم الكامل
+
+686
+01:09:36,890 --> 01:09:41,910
+قليلة، والسبب أن هذا الـ cofactor عندما يعمل هنا
+
+687
+01:09:41,910 --> 01:09:47,110
+لا يعطينا نتيجة جيدة جدًا.
+
+688
+01:09:47,930 --> 01:09:52,750
+بينما عندما أزيد مستوى vitamin cofactor
+
+689
+01:09:52,750 --> 01:09:57,170
+بشكل كبير جدًا، عندما أعطي جرعات عالية جدًا في الحالة
+
+690
+01:09:57,170 --> 01:10:04,830
+هذه، يعني أُجبر الـ cofactor على أن يلتصق بالـ
+
+691
+01:10:04,830 --> 01:10:11,810
+حتى الإنزيم المُعطّل، بحيث يحسن
+
+692
+01:10:11,810 --> 01:10:18,270
+نسبة وظيفة الإنزيم المطلوبة، بحيث يخفف من
+
+693
+01:10:18,270 --> 01:10:27,210
+المرض، فهذه أمثلة على الأمراض
+
+694
+01:10:27,210 --> 01:10:32,050
+والحالات، وأمثلة
+
+695
+01:10:32,050 --> 01:10:39,310
+عليها،  ملاحظات جميلة كثيرة، أفكار
+
+696
+01:10:39,310 --> 01:10:45,260
+جميلة، كيف الواحد يعالج، يخلص من المشاكل، أحيانًا تعويض
+
+697
+01:10:45,260 --> 01:10:51,000
+البروتين نفسه، أحيانًا تعديل إذا كان شيء يساعد على أن
+
+698
+01:10:51,000 --> 01:11:01,700
+المرض لا يظهر، وهنا يُكرّرون نفس الأفكار
+
+699
+01:11:01,700 --> 01:11:08,950
+لأن الكثير منها من الأشياء، حاطّين Investigational
+
+700
+01:11:08,950 --> 01:11:13,670
+وInvestigational، مبسوطين هنا لأنه سهل، تجارب
+
+701
+01:11:13,670 --> 01:11:14,850
+التجاربية
+
+702
+01:11:14,850 --> 01:11:14,970
+التجاربية
+
+703
+01:11:14,970 --> 01:11:16,290
+التجاربية
+
+704
+01:11:16,290 --> 01:11:18,210
+التجاربية
+
+705
+01:11:18,210 --> 01:11:20,310
+التجاربية
+
+706
+01:11:20,310 --> 01:11:26,110
+التجاربية
+
+707
+01:11:26,110 --> 01:11:36,970
+التجاربية... يعني ليس
+
+708
+01:11:36,970 --> 01:11:43,110
+يعطي ماذا؟ لمرضى لديهم نسبة قليلة من الموت، لا، هذا
+
+709
+01:11:43,110 --> 01:11:49,810
+يجب أن تُثبت أن الدواء أو التدخل أو طريقة العلاج أولًا
+
+710
+01:11:49,810 --> 01:11:55,990
+شيء غير قاتل في هذه الناحية أو غير ضار في هذه
+
+711
+01:11:55,990 --> 01:12:00,020
+المرحلة الأولى، ويكون عدد قليل، إذا ثبت والله إنه
+
+712
+01:12:00,020 --> 01:12:04,980
+عمل جيد، لا خطر فيه، لا ضرر فيه، ننتقل للمرحلة الثانية
+
+713
+01:12:04,980 --> 01:12:13,000
+نزيد عدد الحالات، ونبحث عن، نقيم الأثر
+
+714
+01:12:13,000 --> 01:12:17,640
+في التحسين، في الأثر الذي أريده، أنتم الآن
+
+715
+01:12:17,640 --> 01:12:25,660
+تتابعون السباق العالمي لـCovid-19
+
+716
+01:12:25,660 --> 01:12:30,060
+Vaccine، دائمًا يقولون Stage 1 و Stage 2 و Stage
+
+717
+01:12:30,060 --> 01:12:39,300
+3 أو Phase 1 و Phase 2 و Phase 3، يعني قبل أن، حتى
+
+718
+01:12:39,300 --> 01:12:44,980
+نثبت أن الدواء فعال وغير ضار، هاتين
+
+719
+01:12:44,980 --> 01:12:50,870
+الناحيتين، ويكون في البداية، حتى نثبت هذا الكلام من
+
+720
+01:12:50,870 --> 01:12:54,690
+خلال دراسات، كما رأيتم قبل قليل، تكون القضية أن
+
+721
+01:12:54,690 --> 01:13:01,090
+أعطي الناس  placebo، أعطيهم ماء ملح، أو لا أعطيهم شيء حقيقي
+
+722
+01:13:01,090 --> 01:13:06,550
+يعني، وذلك لأنها
+
+723
+01:13:06,550 --> 01:13:12,670
+تكون دراسة بشكل سليم، وتكون كما يقولون
+
+724
+01:13:12,670 --> 01:13:17,890
+أعمى، أعمى، يعني الطبيب المعالج والمريض نفسه
+
+725
+01:13:17,890 --> 01:13:21,950
+لا يعرف إن كان قد أعطي الدواء الحقيقي الذي ندرسه
+
+726
+01:13:21,950 --> 01:13:28,150
+أم أعطي placebo، ماء وملح، لا شيء فيه، لأن
+
+727
+01:13:28,150 --> 01:13:32,050
+العامل النفسي له تأثير كبير، أحيانًا يكون في تحسن
+
+728
+01:13:32,050 --> 01:13:36,630
+بالمرضى، 30% من تأثير الأدوية عادة ما يكون  placebo
+
+729
+01:13:36,630 --> 01:13:41,990
+يعني، ممكن
+
+730
+01:13:43,260 --> 01:13:49,920
+RNA interference، يعني أن أعطي قطعة RNA، أنا
+
+731
+01:13:49,920 --> 01:13:54,040
+لا أعرف هذا، ليس لدي خبرة فيه، induction of axons
+
+732
+01:13:54,040 --> 01:13:59,180
+skipping،  جين إديتنج، الجين إديتنج يعني
+
+733
+01:13:59,180 --> 01:14:06,240
+هذا الموضوع، إذا أردنا أن نتخيله كطريقة علاج، جيد
+
+734
+01:14:06,240 --> 01:14:14,290
+جدا، ولكن حتى الآن، حسب علمي، لا يوجد، ليس هناك
+
+735
+01:14:14,290 --> 01:14:17,550
+تعديلها،
+
+736
+01:14:17,550 --> 01:14:25,990
+يعني استخدامها في نوع من العلاج
+
+737
+01:14:25,990 --> 01:14:32,090
+مرض معين، كعلاج مقبول وجيد، هذا هو موضوع
+
+738
+01:14:32,090 --> 01:14:41,710
+CRISPR9، هذا نوع من الأساليب المتطورة جدا في المعالجة
+
+739
+01:14:41,710 --> 01:14:46,230
+الوراثية Gene Editing، يعني أن أصبح لدي
+
+740
+01:14:46,230 --> 01:14:53,770
+إمكانية أن أمسك أي قطعة من الـ DNA أريدها، وهي
+
+741
+01:14:53,770 --> 01:14:59,310
+اكتُشفت من خلال البكتيريا وآلياتها في الدفاع عن
+
+742
+01:14:59,310 --> 01:15:05,730
+نفسها، نقل الخواص ودفاعها ضد الأمراض أو الغزو
+
+743
+01:15:05,730 --> 01:15:12,340
+من الفيروسات أو من شيء آخر، تُستخدم البروتينات أو
+
+744
+01:15:12,340 --> 01:15:18,820
+الآليات الخاصة بـ CRISPR9، الـ CRISPR9 يعني الجين إديتنج
+
+745
+01:15:18,820 --> 01:15:23,420
+يعني أنا أحضر قطعة الـ DNA التي أريدها، إذا كان
+
+746
+01:15:23,420 --> 01:15:29,720
+مثلًا في مكان ما ثايمين، أضع أدينين، أضع
+
+747
+01:15:29,720 --> 01:15:34,680
+جوانين، أضع ما أريد، في مكان محدد، أشيل الـ
+
+748
+01:15:34,680 --> 01:15:39,780
+Nucleotide وأضع شيء آخر كما أريد، الآن
+
+749
+01:15:39,780 --> 01:15:42,840
+استخدام
+
+750
+01:15:42,840 --> 01:15:47,120
+هذه التقنية، إذا تمكنوا من إثبات أنها جيدة
+
+751
+01:15:47,120 --> 01:15:54,900
+لموضوع مثل الثلاسيميا، مثل التليف الكيسي،
+
+752
+01:15:54,900 --> 01:16:00,480
+عندما يكون الأمر سهلًا، عندما نعرف المطلوب، ونعرف الخلل
+
+753
+01:16:00,480 --> 01:16:05,460
+الموجود، ونعرف الطفرة بالتحديد، يكون مقبولًا
+
+754
+01:16:05,460 --> 01:16:06,940
+وجيدًا أخلاقيًا
+
+755
+01:16:10,740 --> 01:16:16,020
+بالنسبة لـ CRISPR، الأشخاص الذين استخدموه فعليًا
+
+756
+01:16:16,020 --> 01:16:24,760
+بشكل غير أخلاقي، هم في الصين، شخص (يُعتبرونه)
+
+757
+01:16:24,760 --> 01:16:33,040
+مختلاً، وحُجِر عليه، وحُبس بعد ذلك، وطبيب حاول أن يعمل
+
+758
+01:16:33,040 --> 01:16:42,340
+CCR5  جين  activation في الأجنة
+
+759
+01:16:42,340 --> 01:16:51,040
+تابعة لعائلة مصابة بفيروس نقص المناعة البشرية،  الفكرة هنا أن الأب
+
+760
+01:16:51,040 --> 01:17:02,280
+غني جدًا، صيني أظن، استخدم CRISPR في الجنين، يعني
+
+761
+01:17:02,280 --> 01:17:10,220
+في الـ fertilized egg، حتى الآن، يعني... يعني هنا
+
+762
+01:17:10,220 --> 01:17:14,580
+يعطينا مجالًا للعب بالمواد الوراثية للإنسان
+
+763
+01:17:14,580 --> 01:17:23,040
+أو الكائن الحي، فلنكن...  يعني بعيدًا عن
+
+764
+01:17:23,040 --> 01:17:29,500
+المشاكل الأخلاقية، الوراثة تُدخِلنا في مشاكل... أن
+
+765
+01:17:29,500 --> 01:17:35,030
+إذا كان لدي مرض معروف، وأستخدم هذه التقنية من أجل
+
+766
+01:17:35,030 --> 01:17:40,610
+علاج المرض، هذا مقبول، وإذا استطعت أن تُثبت أنه جيد،
+
+767
+01:17:40,610 --> 01:17:46,190
+تمام، لكن هذه التجربة الصينية كانت في
+
+768
+01:17:46,190 --> 01:17:54,010
+أنهم يحاولون، حسب الطفرة في CCR5 التي
+
+769
+01:17:54,010 --> 01:17:58,150
+تحدثنا عنها مرة،  نسبة من التغيرات للـ
+
+770
+01:17:58,150 --> 01:18:03,210
+الإستعداد للإصابة بفيروس نقص المناعة البشرية،  هناك من لاحظوا أن
+
+771
+01:18:03,210 --> 01:18:06,930
+حتى لو تَعَرَّضوا للفيروس، لا يُصابون، لا يستطيع الفيروس أن يدخل
+
+772
+01:18:06,930 --> 01:18:13,260
+داخل الخلايا، والسبب أنهم يمتلكون شكلًا مختلفًا من CCR5، هذا
+
+773
+01:18:13,260 --> 01:18:18,200
+الصيني أراد أن بناته لا يتعرضن، لأن هو وزوجته كانا
+
+774
+01:18:18,200 --> 01:18:21,840
+يأخذان أدوية، ويعالجان أنفسهما، لكن
+
+775
+01:18:21,840 --> 01:18:27,180
+أراد زيادة في التأكيد، أراد أن أجنة أولاده
+
+776
+01:18:27,180 --> 01:18:34,400
+وبناته يمتلكون، أو يمتلكن الجين المقاوم بهذه
+
+777
+01:18:34,400 --> 01:18:45,740
+الطريقة، فاستخدموا CRISPR على الأجنة، وهذا أخلاقيًا
+
+778
+01:18:45,740 --> 01:18:54,840
+غير مقبول، والسبب أن هذا الشيء دينيًا وعلميًا وأخلاقيًا
+
+779
+01:18:54,840 --> 01:19:00,930
+حتى الآن حرام ومُجرّم، ولذلك، حتى هناك محاولات لمنع
+
+780
+01:19:00,930 --> 01:19:06,670
+إجراء الدراسات على الأجنة، والأجنة جزء منها
+
+781
+01:19:06,670 --> 01:19:12,690
+يكون زيادة عن عمليات التلقيح الصناعي In
+
+782
+01:19:12,690 --> 01:19:17,090
+vitro fertilization،  أحيانًا تبقى أجنة زائدة
+
+783
+01:19:17,090 --> 01:19:21,010
+فمن يحاول العمل على هذه الأشياء تكون غير
+
+784
+01:19:21,010 --> 01:19:26,550
+مُنظَّمة، فللآن الجين إديتنج واعد
+
+785
+01:19:26,550 --> 01:19:35,630
+ممكن أن يُستخدم، ولكن هناك مشاكل أخلاقية، يمكن للواحد
+
+786
+01:19:35,630 --> 01:19:41,570
+أن يعمل زرع نخاع، Core Blood Stem
+
+787
+01:19:41,570 --> 01:19:47,750
+Cell Transplantation، زرع كبد، أيضًا
+
+788
+01:19:47,750 --> 01:19:55,290
+ممكن، خاصة في الكبد، هناك قضية أن
+
+789
+01:19:55,290 --> 01:20:00,210
+أحيانًا كثيرة، الإنزيمات الخاصة بالتمثيل الغذائي تكون في
+
+790
+01:20:00,210 --> 01:20:05,070
+الكبد، فلما ينقل شخص كبدًا سليمًا لشخص آخر
+
+791
+01:20:05,070 --> 01:20:13,490
+ممكن أن يعوّض المشاكل، يعني
+
+792
+01:20:13,490 --> 01:20:19,770
+أيضًا دراسات، أشياء أخرى، الفكرة
+
+793
+01:20:19,770 --> 01:20:25,290
+في  Bomber أن
+
+794
+01:20:25,290 --> 01:20:29,810
+الميزة في الـ Bomber أو الـ Stem Cell
+
+795
+01:20:29,810 --> 01:20:37,490
+يقولون أن آليتها، وأدائها، يعني نقل الكبد يعني
+
+796
+01:20:37,490 --> 01:20:44,970
+عملية خطيرة وطويلة ومعقدة، ولها مشاكلها
+
+797
+01:20:44,970 --> 01:20:51,490
+الكبيرة، أن ينقل الشخص الكبد، سواء المتبرع
+
+798
+01:20:51,490 --> 01:20:58,210
+حي، قريب للمريض، أو من متبرع متوفي
+
+799
+01:20:58,210 --> 01:21:05,850
+دماغيًا، دائمًا هناك مشكلات كبيرة، أظن هكذا
+
+800
+01:21:05,850 --> 01:21:09,830
+Somatic
+
+801
+01:21:09,830 --> 01:21:13,690
+tissue،  الـ
+
+802
+01:21:13,690 --> 01:21:18,880
+Gene Therapy،  هنا في العلاج بالخلايا الجسدية، نحاول أن
+
+803
+01:21:18,880 --> 01:21:23,360
+نضع...
+
+804
+01:21:23,360 --> 01:21:29,620
+الفكرة هنا، كما ذكرت في مثال CRISPR،
+
+805
+01:21:29,620 --> 01:21:36,960
+هو عبارة عن أخذ الخلية الملقحة الأولى، وتعديل
+
+806
+01:21:36,960 --> 01:21:42,270
+فيها، النتيجة أن التغيير والتعديل الذي
+
+807
+01:21:42,270 --> 01:21:46,450
+قمت به موجود في كل الخلايا، أما لو أخذت جزءًا من
+
+808
+01:21:46,450 --> 01:21:51,790
+الخلايا في جسم الإنسان كاملاً، وعدّلت فيها شيئًا، وأعدتُها
+
+809
+01:21:51,790 --> 01:21:56,670
+إليه، هذه تُسمى تعديل الخلايا الجسدية
+
+810
+01:21:56,670 --> 01:22:03,970
+Somatic Tissue Modification، مثلًا أخذت من إنسان قطعة كبد
+
+811
+01:22:03,970 --> 01:22:09,130
+وبعد ذلك بالطريقة، وأنا أضع إن الناقل الفيروسي العكسي
+
+812
+01:22:09,130 --> 01:22:14,410
+Retroviral Vector، أو بأسلوب معين، أدخلت شيء آخر، الجانب المهم في
+
+813
+01:22:14,410 --> 01:22:18,510
+إدخال جينات جديدة عبر الـ Bomber هو أسهل واحد
+
+814
+01:22:18,510 --> 01:22:23,630
+وأكثر واحد يُستخدم في أشياء كثيرة، أظن هكذا
+
+815
+01:22:23,630 --> 01:22:35,750
+انتهينا من الأمثلة، إن شاء الله تكون... هذا فصل فيه
+
+816
+01:22:35,750 --> 01:22:49,170
+أشياء كثيرة، متقدم جدًا، أحيانًا ما زال غير مُثبت
+
+817
+01:22:49,170 --> 01:22:58,470
+كثيرًا، يجب أن يكون الواحد متأكدًا منها، وتحتاج خبرة طبية قوية جدًا،
+
+818
+01:22:58,470 --> 01:23:05,370
+متقدمة،  يجب أن يكون لديه خبرة وفهم، طبعًا، في الأمراض
+
+819
+01:23:05,370 --> 01:23:10,020
+الوراثية بهذا الشكل، في الغالب، غير
+
+820
+01:23:10,020 --> 01:23:13,600
+الثلاسيميا أو مرض الخلايا المنجلية، لأنها قريبة جدًا من
+
+821
+01:23:13,600 --> 01:23:20,160
+كثير من الأشياء، بحيث تكون نادرة، وجزء من فاعلية
+
+822
+01:23:20,160 --> 01:23:31,160
+وتحسن الدواء المعين، هو أنه يتم
+
+823
+01:23:31,160 --> 01:23:39,700
+تجربته من خلال تجارب علمية سليمة وجيدة، إذا كان لدى أحد
+
+824
+01:23:39,700 --> 01:23:50,680
+أسئلة، فمرحباً بكم، أو نختم هكذا، سؤال
+
+825
+01:23:50,680 --> 01:23:57,660
+يا دكتور من كريم، بخصوص الأمراض والتدخلات التي تم
+
+826
+01:23:57,660 --> 01:24:05,380
+ذكرها، كلها، تقول أن عددها كبير وأنواعها كثيرة، ماذا
+
+827
+01:24:05,380 --> 01:24:11,040
+الذي يجب أن نركز عليه منها؟ أو ما الذي يُفترض أن نحفظه
+
+828
+01:24:11,040 --> 01:24:19,040
+منها بهذا المعنى؟ لا، أنظر، أُقترح أن نركز على
+
+829
+01:24:19,040 --> 01:24:24,360
+ما تحدثت عنه في المحاضرات،  الوذمة الوراثية،
+
+830
+01:24:24,360 --> 01:24:30,650
+Hereditary Angioneurotic Edema، موجود، أستخدمه،
+
+831
+01:24:30,650 --> 01:24:37,270
+وعندي مثلًا المصابين بهيموفيليا،  أعطيهم البروتين
+
+832
+01:24:37,270 --> 01:24:43,310
+هذا واضح ومستخدم جدًا، ومرضى الهيموفيليا...
+
+833
+01:24:43,310 --> 01:24:48,090
+يأتون إلى الطوارئ، ويكون لديهم نزيف في العضلات، في
+
+834
+01:24:48,090 --> 01:24:52,150
+المفاصل، في ...، هذا مرض النزف الشديد، الذي هو
+
+835
+01:24:52,150 --> 01:24:57,570
+الهيموفيليا، الذي هو شدة النزيف، ترى؟ فهي
+
+836
+01:24:57,570 --> 01:25:04,170
+الأشياء التي أظن...  أركز الواحد عليها،
+
+837
+01:25:04,170 --> 01:25:09,710
+جداول في قضية المبادئ،  حريصٌ على أن في المحاضرة
+
+838
+01:25:09,710 --> 01:25:16,430
+أشرح المبدأ، وأعطيكم بعض المعلومات السريرية، فهي
+
+839
+01:25:16,430 --> 01:25:22,020
+التي أتوقع أن ما تحدّثت عنه هو ما يجب أن تركزوا عليه
+
+840
+01:25:22,020 --> 01:25:27,880
+وهذا فقط في المحاضرة، بالنسبة
+
+841
+01:25:27,880 --> 01:25:35,560
+للذين يحكون معلومة، ويضعونها ضمن تجارب معينة،
+
+842
+01:25:35,560 --> 01:25:42,380
+هذا دليل على أنها ليست ثابتة ومعتمدة، لكن يظل
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/u_JvIjOn4A0_postprocess.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/u_JvIjOn4A0_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..d66bd4565f2f79fcbca4f57f8560f9ec3a962d69
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/u_JvIjOn4A0_postprocess.srt
@@ -0,0 +1,2912 @@
+1
+00:00:02,080 --> 00:00:09,880
+الـ Share أمورنا
+
+2
+00:00:09,880 --> 00:00:19,600
+كويسة في شباب وداخلين أربعة لسه طيب نبدأ
+
+3
+00:00:19,600 --> 00:00:24,320
+زي كل مرة في الأول في أسئلة على الأشياء اللي تم
+
+4
+00:00:24,320 --> 00:00:28,240
+نقاشها من قبل في حد عنده سؤال في الوراقة
+
+5
+00:00:33,750 --> 00:00:42,310
+إذا في حد عنده سؤال يعني يتكلم بس إحنا يعني
+
+6
+00:00:42,310 --> 00:00:46,450
+بالنسبة لمحاضرة اليوم اللي كان المفروض الأسبوع
+
+7
+00:00:46,450 --> 00:00:51,470
+اللي فات وكان فيها مشكلة بالنسبة انقطعت الكهربا
+
+8
+00:00:51,470 --> 00:00:59,950
+واتخرّبت الأمور إحنا ندخل الآن في أمثلة متعددة عن
+
+9
+00:00:59,950 --> 00:01:11,770
+أنواع من الأمراضالوراطية ونحاول نعمل شرح عن يعني
+
+10
+00:01:11,770 --> 00:01:20,570
+مسبباتها وأنواع الطفرات، أنواع الأليات الـ
+
+11
+00:01:20,570 --> 00:01:29,910
+Mechanisms لتسبب بهذه الأمراض الوراطية صراحة يعني
+
+12
+00:01:29,910 --> 00:01:36,500
+الـالليست طويلة، القائمة طويلة من الأمراض اللي
+
+13
+00:01:36,500 --> 00:01:44,680
+حاطينها في الكتاب وأنا يعني اللي بديها من ناحية
+
+14
+00:01:44,680 --> 00:01:53,540
+تانية، من ناحية الأولى اللي هي إن الواحد يعني لما
+
+15
+00:01:53,540 --> 00:01:59,480
+تقوله يتطلع على القائمة هذه وعلى الأقل هي نسبياً
+
+16
+00:01:59,480 --> 00:02:04,650
+بالنسبة لعدد الأمراضالوراثية المعروفة هي لسة قصيرة
+
+17
+00:02:04,650 --> 00:02:14,750
+جداً وإشي يعني قليل كثير ولكن الأمراض في الـ في
+
+18
+00:02:14,750 --> 00:02:22,930
+الحياة وعند أي population إذا حنتشوف بتلاقوا أمراض
+
+19
+00:02:22,930 --> 00:02:31,860
+متنوعة وكثير كثير فبدي أنه الواحد يكون عندهيعني
+
+20
+00:02:31,860 --> 00:02:37,380
+قدرة على إنه لما يعرف إنه فيه مرض فلاني كيف يرجع
+
+21
+00:02:37,380 --> 00:02:42,660
+لمرجع يعني الآن أنا بستخدم كثير الـInternet
+
+22
+00:02:42,660 --> 00:02:48,500
+وGoogle على أساس الـOnline Source
+
+23
+00:02:48,500 --> 00:02:55,620
+للـGenetic Mendelian Diseases وبشوف، بقرا عن شُو
+
+24
+00:02:55,620 --> 00:03:00,740
+كاتبين عن الموضوع هذافيعني الواحد يربي نفسه أو
+
+25
+00:03:00,740 --> 00:03:07,380
+يعلم حاله على إنه يقدر يرجع لمرجع معين يقرأ عن أي
+
+26
+00:03:07,380 --> 00:03:12,820
+مرض وكذا، والمطلوب التاني إنه يقدر الواحد إيش هي
+
+27
+00:03:12,820 --> 00:03:17,420
+الـGenetic Mechanism أتكلمنا على أنواع مشاكل
+
+28
+00:03:17,420 --> 00:03:27,780
+كثيرة، فنتكلم عنهم يعني قصدي على أنواع المشاكلاللي
+
+29
+00:03:27,780 --> 00:03:36,020
+بتعمل مشاكل في الوراطة وبتكون أمراض وراطية فيه
+
+30
+00:03:36,020 --> 00:03:43,700
+كأنه مؤتز رافع إيده أو إشي؟
+
+31
+00:03:43,700 --> 00:03:51,440
+لأ تمام الأمور بالتأكيد طيب بالنسبة لكتابكم
+
+32
+00:03:52,520 --> 00:03:56,960
+حاطط الـ… الـ… طبعاً احنا أخدنا بالمحاضرة اللي
+
+33
+00:03:56,960 --> 00:04:01,040
+فاتت السابقة الـHemoglobinopathies واتكلمنا على
+
+34
+00:04:01,040 --> 00:04:06,560
+أنواعهم وسمينا الـSicklers والـParsimias والأنواع
+
+35
+00:04:06,560 --> 00:04:12,540
+التانية وأخدناهم كشيء يعني متخصص درسنا أنواع
+
+36
+00:04:12,540 --> 00:04:19,940
+الـGenetic Mutations اللي بتعملهم كترتيب
+
+37
+00:04:19,940 --> 00:04:25,220
+للمجموعةالأمراض اللي حاططها وانا بقدر هنا يعني
+
+38
+00:04:25,220 --> 00:04:30,100
+حاطط لكم تقريبًا دي أربعة، ستة، اتنين، أربعة، عشرة
+
+39
+00:04:30,100 --> 00:04:35,400
+يعني حاططت خمسة وعشرين، تلاتين المرض تقريبًا طالب
+
+40
+00:04:35,400 --> 00:04:41,160
+انكم على الأقل يكون الواحد منكم عارف إيش هي وإيش
+
+41
+00:04:41,160 --> 00:04:45,300
+نوعية المشكلة اللي موجودة فيها وكيف ال
+
+42
+00:04:48,260 --> 00:04:55,120
+فهن الآن التفرات أو الأمراض الوراثية أو الأليات
+
+43
+00:04:55,120 --> 00:05:01,440
+اللي تسببت في المرض هذا فطريقة تقسيم الكتاب
+
+44
+00:05:01,440 --> 00:05:08,820
+بالنسبة لهذا الموضوع إنه حاكتهم على شكل يعني
+
+45
+00:05:08,820 --> 00:05:17,720
+مجموعات ضمن تركيب الخلية ففي مجموعة أمراض بتكون
+
+46
+00:05:17,720 --> 00:05:22,240
+فيها مشاكل في الـ organelles العضييات اللي جوا
+
+47
+00:05:22,240 --> 00:05:26,760
+القضية أو أولهم الـ mitochondria فحاطين liver
+
+48
+00:05:26,760 --> 00:05:32,340
+liver hereditary optic neuropathy وفي LD1 protein
+
+49
+00:05:32,340 --> 00:05:39,320
+أو electron transport chain defects فحاطت أمثلة
+
+50
+00:05:39,320 --> 00:05:44,140
+Transition Translation of the mitochondrial
+
+51
+00:05:44,140 --> 00:05:52,050
+proteinsزي الـ Mylas إحنا راح ناخد واحد منهم ونشوف
+
+52
+00:05:52,050 --> 00:05:57,730
+يعني هيكون هو شارع يفترض إنه الواحد منكم لما نقرأ
+
+53
+00:05:57,730 --> 00:06:00,870
+صحيح يعني يمكن المرض الواحد ماشوفش ولا حالة منه
+
+54
+00:06:01,330 --> 00:06:07,790
+بكون هذا يعني مزعج
+
+55
+00:06:07,790 --> 00:06:15,310
+أو يعني حالة يعني بسبب ضعف اللي الواحد يفهم شو هو
+
+56
+00:06:15,310 --> 00:06:21,380
+المرض يعني مش زي لما نيش كون شاب حالةوفي الـ
+
+57
+00:06:21,380 --> 00:06:26,740
+Paroxysomes زي الـ Zolliger's Syndrome اللي هي فيه
+
+58
+00:06:26,740 --> 00:06:32,240
+12 بروتين أو الـ Lysosomes زي الـ Tysax Disease أو
+
+59
+00:06:32,240 --> 00:06:35,920
+الـ Hurler's Syndrome في الـ Extracellular
+
+60
+00:06:35,920 --> 00:06:41,080
+Proteins الـ Transplant زي حكينا الـ Globulin في
+
+61
+00:06:41,080 --> 00:06:43,600
+الـ Hemoglobin زي الـ Sickles الأنيميا أو
+
+62
+00:06:43,600 --> 00:06:47,960
+التلسينيا الـ Morphogenes اللي هي زي
+
+63
+00:06:53,290 --> 00:07:00,950
+Follow انسفلوباتي، انتهاب الدماغ، انتسيم أو Alpha
+
+64
+00:07:00,950 --> 00:07:04,510
+-1-antitrypsin deficiency زي البروتيز انهيبتر
+
+65
+00:07:05,100 --> 00:07:11,740
+Hemostasis زي الـHemophilia A وB الـHormones زي
+
+66
+00:07:11,740 --> 00:07:14,960
+الإنسوين في الـRare Forms بتعتودي أبيتس
+
+67
+00:07:14,960 --> 00:07:20,520
+الـCollagen زي الـCollagen Type I Disease
+
+68
+00:07:20,520 --> 00:07:26,340
+الـOestrogenesis Imperfecta الـComplement زي
+
+69
+00:07:26,340 --> 00:07:31,080
+الـHereditary Angioneurotic بقديمة Complement
+
+70
+00:07:31,080 --> 00:07:35,480
+After Hالحققانة اللي هو الـ Age-related macular
+
+71
+00:07:35,480 --> 00:07:40,980
+degeneration الـ Metabolic enzymes زي الـ Pq فنع
+
+72
+00:07:40,980 --> 00:07:47,240
+الكيتون أيوريا اللي هو الفنع الأناني الـ disease
+
+73
+00:07:47,240 --> 00:07:51,120
+أو الـ Adenosine Deaminase اللي هو السبب للـ SCID
+
+74
+00:07:51,120 --> 00:07:54,820
+Severe Combined Immune Deficiency أو Duchene
+
+75
+00:07:54,820 --> 00:08:01,340
+Muscular Dystrophin بسبب مشكلة الدستروفينأو بالـ
+
+76
+00:08:01,340 --> 00:08:07,300
+Nucleus itself زي الـ Aniridia اللي هي أنه مافيش
+
+77
+00:08:07,300 --> 00:08:14,200
+Iris فيه مشكلة Brachia 102 اللي هم دخل بالكانسر
+
+78
+00:08:14,200 --> 00:08:21,410
+Hereditary Non-polyposis Colon CancerDNA mismatch،
+
+79
+00:08:21,410 --> 00:08:25,890
+repair of proteins، fragile eggs syndrome،
+
+80
+00:08:25,890 --> 00:08:34,430
+retinoblastoma، مشكلة السرطان ومشكلة الشبكية،
+
+81
+00:08:34,430 --> 00:08:42,750
+الـCML، الفرديل فيه كرومزوم، الـcell surface زي
+
+82
+00:08:42,750 --> 00:08:48,170
+الـandrogen insensitivity أو الـachondroplasia
+
+83
+00:08:50,380 --> 00:08:54,460
+أو الـ Hypercholesterolemia أو الـ Cystic Fibrosis
+
+84
+00:08:54,460 --> 00:08:57,560
+أو الـ Type 1 Diabetes يعني هذه الأمثل اللي بدنا
+
+85
+00:08:57,560 --> 00:09:03,300
+ناخدها إذا
+
+86
+00:09:03,300 --> 00:09:09,300
+بدنا نحاول نشوف أو إذا كان هو شارع كتير بس بدي
+
+87
+00:09:09,300 --> 00:09:15,160
+يكون الواحد لما يقرأ تفاصيل المرض بدي نحاول إن
+
+88
+00:09:15,160 --> 00:09:21,520
+احنا نوصل اليوم فيه إنه كيفالاختلال الجين أدى
+
+89
+00:09:21,520 --> 00:09:25,900
+للمظهر اللي عندنا وشوهي الاختلالات اللي كانت في
+
+90
+00:09:25,900 --> 00:09:33,720
+الجينات من أي ناحية وكيف نتجت عنها الأمراض
+
+91
+00:09:33,720 --> 00:09:41,200
+هذه بدنا نتذكر أنه يعني الآن صحيح الجين في الغالب
+
+92
+00:09:41,200 --> 00:09:45,000
+مش قطعة واحدة في Exons and Trons بحيث أنه أحنا
+
+93
+00:09:45,000 --> 00:09:52,620
+بحاجةإنه أدت قطع بالأخير تمت إلى قضية الـ
+
+94
+00:09:52,620 --> 00:09:58,600
+Transcription لتنطلق الـ RNA فحتى تعرف آلية الخلية
+
+95
+00:09:58,600 --> 00:10:04,840
+من أين تبدأ أو أين تتوقف لازم فيه Control لازم فيه
+
+96
+00:10:04,840 --> 00:10:10,000
+آليات تحكم ففي منطقة الـ Promoter Region الـ
+
+97
+00:10:10,000 --> 00:10:18,360
+Startup Cordon فيه آليات وفيهأشياء حتى تنشط هذا
+
+98
+00:10:18,360 --> 00:10:23,860
+الـ Gene وتبقى تعرف من وين تبدأ و لوين تتوقف فهذه
+
+99
+00:10:23,860 --> 00:10:29,120
+آلية قد تصعب نفس الـ Gene قد تحدث ليه مشكلة بعد
+
+100
+00:10:29,120 --> 00:10:33,720
+هيك لما يطلع الـ Messenger RNA بدي تم عليه شغل
+
+101
+00:10:33,720 --> 00:10:39,690
+أحياناً الشغل هذا هو اللي بيكون فيه مشكلةالحال
+
+102
+00:10:39,690 --> 00:10:48,910
+الأولى اللي بتكلموا عنها إشي اسمه الـ Penile
+
+103
+00:10:48,910 --> 00:10:58,130
+Pitoneuria الـ PQ الـ PQ مرض يعني تقريبًا يعني
+
+104
+00:10:58,130 --> 00:11:03,510
+أحنا بالأردن ما بين 300 لـ 800 مصاب فيهيعني
+
+105
+00:11:03,510 --> 00:11:08,630
+تقريبًا واحد بالألف وواحد بالثلاثمية وواحد
+
+106
+00:11:08,630 --> 00:11:17,690
+بالخمسمية فيه تفاوت في الـ فيه تفاوت في النسب
+
+107
+00:11:17,690 --> 00:11:22,870
+وخصوصًا إنه بالذات مع الـ Consanguinity زواج
+
+108
+00:11:22,870 --> 00:11:27,770
+الأقارب يكون نسبة الحدود أكبر بكتير إبارة عن
+
+109
+00:11:27,770 --> 00:11:30,050
+بالأخير مجموعة
+
+110
+00:11:33,810 --> 00:11:38,770
+«بيوكيميكال باثوية» «anomalies» «التي ستؤدي إلى
+
+111
+00:11:38,770 --> 00:11:44,230
+الهيبرفنال الألانين» الفنال الألانين أحد الـ Amino
+
+112
+00:11:44,230 --> 00:11:53,150
+Acid إذا بزيد كثير بعمل مشكلة بالدرجة بالنسبة للـ
+
+113
+00:11:53,150 --> 00:11:57,590
+nervous system development يعني بيصير أنه ليس
+
+114
+00:11:57,590 --> 00:12:02,810
+الجهاز العصبي في خللفي الـClassical ones الشعرهم
+
+115
+00:12:02,810 --> 00:12:07,610
+بيكون على لون أحمر شوية هي في لونه شوية مختلف مميز
+
+116
+00:12:07,610 --> 00:12:14,590
+نوعاً ما بس يمكن يولدوا في الغالب نتيجة أنه الفناء
+
+117
+00:12:14,590 --> 00:12:20,450
+الأنانين في خلال فترة الحمل يعني بتتم التحكم فيه
+
+118
+00:12:20,450 --> 00:12:28,630
+كمان عن طريق الأم هي انه ممكن لو ارتفعيتم تنزيله
+
+119
+00:12:28,630 --> 00:12:35,330
+عن طريق الـ Metabolism تبع الأم بعد
+
+120
+00:12:35,330 --> 00:12:40,270
+الولادة بتظل مرتفع وبتصير فيه مشكلة الـ
+
+121
+00:12:40,270 --> 00:12:47,090
+phenylalanine is metabolized by a hydroxylase it
+
+122
+00:12:47,090 --> 00:12:52,610
+will change it from phenylalanine to tyrosine فهذه
+
+123
+00:12:52,610 --> 00:12:57,830
+النقطة الأساسيةفالـ Phenylalanine Hydrolase هو
+
+124
+00:12:57,830 --> 00:13:03,870
+الإنزايم على أقل في الـ Classical PQ الحلوف
+
+125
+00:13:03,870 --> 00:13:09,990
+أو الملاحظة على الـ PQ اللي هو قضية إنه الـ
+
+126
+00:13:09,990 --> 00:13:17,270
+Treatment تبعته وبذلك عشان نحافظ على الـ Mental
+
+127
+00:13:17,270 --> 00:13:21,770
+Capacityيعني it is a major cause of preventable
+
+128
+00:13:21,770 --> 00:13:29,130
+mental retardation يعني التخلف العقلي ونمو الدماغ
+
+129
+00:13:29,130 --> 00:13:36,810
+في الإنسان إذا تم التنبه لهذه الحالة وعلاجها أو
+
+130
+00:13:36,810 --> 00:13:41,010
+التعامل معاها بالطريقة السليمة اللي هي عن طريق الـ
+
+131
+00:13:41,010 --> 00:13:44,330
+Low Phenyl Alanine Diet يعني اللي هو Low Protein
+
+132
+00:13:44,330 --> 00:13:50,160
+Diet الفنال الألانين موجود فيمجموعة بروتينات
+
+133
+00:13:50,160 --> 00:13:57,220
+وبالتالي لما نكون نعطي نصائح وفيه يعني literature
+
+134
+00:13:57,220 --> 00:14:06,440
+وواضح شوهي الأكلات اللي في تونس فيها يعني الخبز،
+
+135
+00:14:06,440 --> 00:14:10,480
+الدرة،
+
+136
+00:14:10,480 --> 00:14:12,780
+البقوليات
+
+137
+00:14:14,800 --> 00:14:18,060
+الأجبان، يعني كلها بتصير ممنوعة لأن فيها نسبة
+
+138
+00:14:18,060 --> 00:14:25,760
+عالية من البراتين وبالتالي الأهل يعني هي مشكلة ليش
+
+139
+00:14:25,760 --> 00:14:32,140
+أقول يعني دائمة بس مشكلة طويلة بالنسبة للعائلة
+
+140
+00:14:32,140 --> 00:14:36,700
+اللي بيكون عندها مصابين من ناحية إنه بدهم يتفهوا
+
+141
+00:14:36,700 --> 00:14:44,420
+لأكلهم وقضية إن الواحد يوكل أكليعني مخصص مش قضية
+
+142
+00:14:44,420 --> 00:14:54,140
+سهلة يعني بحاجة لـ بحاجة لـ علم و بحاجة لتنبؤ و
+
+143
+00:14:54,140 --> 00:14:59,960
+بحاجة لإرادة و بحاجة لدعم من المجتمع على قضية يعني
+
+144
+00:14:59,960 --> 00:15:05,440
+إحنا في أردن جمعية الـ BQ جمعية الـ Penal Ketone
+
+145
+00:15:05,440 --> 00:15:13,440
+الأردنية أنا عضو فيهاويعني بنوفر الأكلات اللي هي
+
+146
+00:15:13,440 --> 00:15:21,720
+قليلة الملعق قليلة البروتين بعضها يعني ممكن نفس
+
+147
+00:15:21,720 --> 00:15:29,160
+الإنسان يتعامل معها يعني كل الـ كل
+
+148
+00:15:29,160 --> 00:15:31,580
+الورقيات
+
+149
+00:15:32,220 --> 00:15:37,840
+يعني ملوقي، بخص بقدونس، أشياء زي ذلك، فيه أشياء
+
+150
+00:15:37,840 --> 00:15:43,660
+مسموعة وهذه ممكن الإنسان يوقعها وما بتأثرش فالـ
+
+151
+00:15:43,660 --> 00:15:49,360
+بالنسبة للتفرات
+
+152
+00:15:49,360 --> 00:15:58,860
+المتوقعة ثبت بعدين إنه عبارة عن أكثر من نوع وفي
+
+153
+00:15:58,860 --> 00:16:05,290
+عندنا الـ Classical BBQوفي الـ Variant PQ وفي الـ
+
+154
+00:16:05,290 --> 00:16:12,870
+Non-PQ وفي الـ Hyperpylananemia وفي اللي هو الـ
+
+155
+00:16:12,870 --> 00:16:18,770
+Tetrahydrobiopetrine
+
+156
+00:16:18,770 --> 00:16:26,450
+اللي هو BH4 يعني برضه Chemical Mediator
+
+157
+00:16:26,450 --> 00:16:35,130
+في ميكانزم تبعالنقطة هذه فهي الفكرة إنه يعني هاي
+
+158
+00:16:35,130 --> 00:16:41,510
+على الأقل حاطين إنه فيه خمس غير الـ Classical فيه
+
+159
+00:16:41,510 --> 00:16:47,970
+أربع تانيات variant يعني الخمس الـ Classical هو
+
+160
+00:16:47,970 --> 00:16:53,070
+الأشياء يشيل البقية يشيل less than one less than
+
+161
+00:16:53,070 --> 00:16:58,990
+one يعني الـ enzyme that's affectedالأولانيات اللي
+
+162
+00:16:58,990 --> 00:17:03,610
+هو الفلع الأولاني الـ Hydroxylase وفي إنزيمات
+
+163
+00:17:03,610 --> 00:17:08,770
+تانية بحاجة للجسم بتسوي
+
+164
+00:17:08,770 --> 00:17:13,990
+مشاكل تانية فهذه
+
+165
+00:17:13,990 --> 00:17:19,070
+يعني هي من الأمراض الموجودة أمراض حقيقية للواحد
+
+166
+00:17:19,070 --> 00:17:22,610
+بعرفها الـ
+
+167
+00:17:23,130 --> 00:17:30,830
+عبارة عن مظهريًا هو زيادة الفنع الأنانين وإحنا
+
+168
+00:17:30,830 --> 00:17:36,330
+بنقدر نقيص مستوىها في الدم وجزء من مراقبة المريض
+
+169
+00:17:36,330 --> 00:17:44,810
+لمرض هذا إنه بنعمل مستوى الـ Amino Acid هذا وبنشوف
+
+170
+00:17:44,810 --> 00:17:50,510
+اللواء المصل أو هل هو فعلاً ملتزم بالحمية ولا مش
+
+171
+00:17:50,510 --> 00:17:58,700
+ملتزمويعني حقيقةً يعني العلاج السليم لهذه الحالة
+
+172
+00:17:58,700 --> 00:18:04,300
+مفرح إن الواحد يشوف الطفل أو اللي هو بعدين يصير
+
+173
+00:18:04,300 --> 00:18:09,600
+شاب أو بنت ويكون ناجح فاعل في المجتمع وكده كنت أنا
+
+174
+00:18:09,600 --> 00:18:14,980
+لما كنت طالب كنا نسمع عن المرض هذا قبل ما أشوفه
+
+175
+00:18:14,980 --> 00:18:22,280
+كانوا يقولوا بعد عمر السنتين إن الدماغ بيتماستكمال
+
+176
+00:18:22,280 --> 00:18:27,420
+نموه، يعني أهم فترة في الالتزام في الحمياء وفي
+
+177
+00:18:27,420 --> 00:18:33,160
+النمو الطبيعي للجهاز العصبي والدماغ اللي هو أول
+
+178
+00:18:33,160 --> 00:18:38,200
+سنتين في الحياة، فإنه بعدين يعني بيقدر المريض
+
+179
+00:18:38,200 --> 00:18:43,300
+يترافى ويوفي الأشياء عادية، بس ثبت إنه لأ لازم يظل
+
+180
+00:18:43,300 --> 00:18:47,780
+على الحمياء لأنه ممكن ينفذ تخلف عقلي وضرر على
+
+181
+00:18:47,780 --> 00:18:53,700
+الدماغحتى لو بعدين و أكون في فترة تانية فصراحة إن
+
+182
+00:18:53,700 --> 00:18:59,100
+الواحد كمجتمع يتنبه لهذه الحالة ويدعم العائلة اللي
+
+183
+00:18:59,100 --> 00:19:03,860
+عندها المرض هذا طبعا إنه مايتزوجوش من بعض من ناحية
+
+184
+00:19:03,860 --> 00:19:09,720
+و ينصحهم بس كمان قضية توفيرة الأكل خصوصا كثير منهم
+
+185
+00:19:09,720 --> 00:19:15,180
+فقرا أو كثير منهم يعني تجد صعوبة إنه يلاقوا الواحد
+
+186
+00:19:15,180 --> 00:19:20,770
+الأكل المناسب والحقيقيونتيجتها إنه يشوف الواحد
+
+187
+00:19:20,770 --> 00:19:26,730
+الطفل يكون ويصل إنه يكون منتج سليم، معافى، يكون
+
+188
+00:19:26,730 --> 00:19:32,050
+يعني يكون
+
+189
+00:19:32,050 --> 00:19:39,790
+يخلص جامعة، يشتغل بشكل طبيعي، هذه كلها إشي مفيدة
+
+190
+00:19:39,790 --> 00:19:50,970
+الفكرة في الموضوع إنه الـالنوعية المشاكل اللي
+
+191
+00:19:50,970 --> 00:19:59,790
+بتسوي الـ PQ هنا حاطي
+
+192
+00:19:59,790 --> 00:20:04,630
+لكم إنه في البيض نوعية الـ Genetic Variations
+
+193
+00:20:04,630 --> 00:20:12,670
+مختلفة عن الـ ASIA ماشي وهذه قضية بتكون إنه درسوا
+
+194
+00:20:15,180 --> 00:20:20,040
+درسوا الـ Variation طبعًا دولة الـ Classical أتوقع
+
+195
+00:20:20,040 --> 00:20:26,320
+بالـ Classical PQ وبيكونوا
+
+196
+00:20:26,320 --> 00:20:32,140
+يعني حاطينها
+
+197
+00:20:32,140 --> 00:20:37,860
+في حسب ده الواحد قام بدراسة إنه جاب العائلة وفيها
+
+198
+00:20:37,860 --> 00:20:42,320
+مصابين وفيها طبعًا الأب والأم لأن هذا Autosomal
+
+199
+00:20:42,320 --> 00:20:47,030
+Recessiveالأب والأم يكونوا حاملين للمرضى وبالتالي
+
+200
+00:20:47,030 --> 00:20:50,570
+هو «autism recessive» يبين بالـ «females» والـ
+
+201
+00:20:50,570 --> 00:20:54,410
+«females» بتبعض ويكونوا بيشتغلوا بهذه الطريقة
+
+202
+00:20:54,410 --> 00:21:02,570
+الفكرة، لما يحطوا لكم أرقام زي هذه، ناشي؟ يعني
+
+203
+00:21:02,570 --> 00:21:08,510
+مثلًا في أكبر نوع من المشاكل في الـEuropean
+
+204
+00:21:08,510 --> 00:21:19,760
+patientsوانه هنا حوالي 4000 حالة أو 4000 يعني
+
+205
+00:21:19,760 --> 00:21:24,920
+Individual مصاب R408W
+
+206
+00:21:24,920 --> 00:21:34,620
+الـ «R» والـ «W» بدكم تتذكروا هدولة اللي يعني بدنا
+
+207
+00:21:34,620 --> 00:21:43,400
+نتذكر اللي هم الـ Amino Acidsوبكونوا يعني اللي هو
+
+208
+00:21:43,400 --> 00:21:49,880
+الـ Amino acid بتقلهم أكتر من طريقة للكتابة فممكن
+
+209
+00:21:49,880 --> 00:21:56,540
+واحد يكتب Phenylalanine كـ Amino acid يكتبه كامل
+
+210
+00:21:56,540 --> 00:22:01,220
+وفيه بيحطوا ثلاث أحرف وفيه بيرمزولهم بحرف واحد،
+
+211
+00:22:01,220 --> 00:22:06,280
+فيبقى الأخيرإذا بالواحد بيرجع للجدول بيشوف شو الـ
+
+212
+00:22:06,280 --> 00:22:12,180
+«R» بتمثل أنه Amino Acid ماشي و «W» Amino Acid
+
+213
+00:22:12,180 --> 00:22:19,480
+تاني فاللي بيصير أنه بدل كده بيجي كده فبدي أقول في
+
+214
+00:22:19,480 --> 00:22:25,740
+عندنا Substitution لـAmino Acid الـ408 هي
+
+215
+00:22:25,740 --> 00:22:30,700
+الـLocation تبعة الـAmino Acid Substitution هذافهي
+
+216
+00:22:30,700 --> 00:22:36,800
+عبارة عن One letter amino acid code is used في هذه
+
+217
+00:22:36,800 --> 00:22:42,820
+الناحية والـ Position اللي صارت في الـ mutation هم
+
+218
+00:22:42,820 --> 00:22:48,960
+بيحكيوكوا معاها مثل هي بتكون في الغالب زي الموضوع
+
+219
+00:22:48,960 --> 00:22:54,040
+مثلا الـ Sickle cell اللي في الـ Position 6 في الـ
+
+220
+00:22:54,040 --> 00:23:00,350
+Valine صار بدل الـالـ Arginine أو اللي هو الـ
+
+221
+00:23:00,350 --> 00:23:04,970
+Amino Acid اللي صار فيه اختلاف، ماشي؟ طبعاً هدولة
+
+222
+00:23:04,970 --> 00:23:11,610
+مش مطلبات لقدر ما أنه لما أنا أشوف الرمز هذا أكون
+
+223
+00:23:11,610 --> 00:23:17,890
+عندي تصور عن إيش بيته، إنه الآن بالأخير هنا في
+
+224
+00:23:17,890 --> 00:23:24,610
+الـAsians، هنا في الـEuropeans الـ 31% من
+
+225
+00:23:24,610 --> 00:23:29,210
+الـMutation من هذا النوع11% من الـ Mutations من
+
+226
+00:23:29,210 --> 00:23:34,670
+هذا الشكل تست خمسة خمسة خمسة وبعدين مجموعة كبيرة
+
+227
+00:23:34,670 --> 00:23:43,650
+فيها غيرها يعني باختصار مثلا زي مرض تاني مثل FMF
+
+228
+00:23:43,650 --> 00:23:47,770
+«فاميل الميداترانيان تيفر» قمنا عليه دراسة فعندي
+
+229
+00:23:47,770 --> 00:23:53,690
+معلومة أدقة شوية عن هنا الـ Database تبع الـ
+
+230
+00:23:53,690 --> 00:23:58,490
+Mutations لهذه المشكلة في حواليعلى الأقل كان فيه
+
+231
+00:23:58,490 --> 00:24:03,670
+200 ميوتاشيا اللي Recognized فهي يعني بتكون مرات
+
+232
+00:24:03,670 --> 00:24:10,450
+عداد كبيرة من أنواع المشاكل وبتعطينا مضاء قد تكون
+
+233
+00:24:10,450 --> 00:24:16,750
+تفاوت في الإصابة بتعطينا مشاكل في قضية كيف بتقول
+
+234
+00:24:16,750 --> 00:24:22,710
+وبيد الواحد يكون فاهمها كيف يقراها في أمراض تانية
+
+235
+00:24:28,390 --> 00:24:34,670
+زي المرض اللي دخل فيه الـ «هيكسوز» «هيكسوز»
+
+236
+00:24:34,670 --> 00:24:35,570
+«هيكسوز» «هيكسوز» «هيكسوز» «هيكسوز» «هيكسوز»
+
+237
+00:24:35,570 --> 00:24:35,750
+«هيكسوز» «هيكسوز» «هيكسوز» «هيكسوز» «هيكسوز»
+
+238
+00:24:35,750 --> 00:24:35,850
+«هيكسوز» «هيكسوز» «هيكسوز» «هيكسوز» «هيكسوز»
+
+239
+00:24:35,850 --> 00:24:36,010
+«هيكسوز» «هيكسوز» «هيكسوز» «هيكسوز» «هيكسوز»
+
+240
+00:24:36,010 --> 00:24:46,310
+«هيكسوز» «هيكسوز» «هيكسوز» «هيكسوز»
+
+241
+00:24:46,310 --> 00:24:54,070
+«هي
+
+242
+00:24:54,330 --> 00:25:01,390
+الـ الـ يعني الـ metabolism steps ففي مرض اسمه الـ
+
+243
+00:25:01,390 --> 00:25:08,370
+Tysacs عبارة عن يعني هنا الحقين مش يعني خلصنا اصلا
+
+244
+00:25:08,370 --> 00:25:14,850
+من الموضوع الـ في نوع الـ Ketonuria واللي دخل انه
+
+245
+00:25:14,850 --> 00:25:18,830
+بيصير amino acid metabolism anomaly بيصير
+
+246
+00:25:18,830 --> 00:25:24,270
+excessive level of الـأمينو أسد في الجسم، وهو مخطط
+
+247
+00:25:24,270 --> 00:25:31,070
+للعصب مخطط للنظام، ضار للجهاز العصبي هنا حالة
+
+248
+00:25:31,070 --> 00:25:43,250
+ثانية Tyset اسم العلماء اللي اكتشفوها بالأخير يعني
+
+249
+00:25:43,930 --> 00:25:52,270
+بيصير برضه mental retardation procedure lens
+
+250
+00:25:52,270 --> 00:25:59,290
+problems cherry red spots يعني لما نيجي نبحث عيون
+
+251
+00:25:59,290 --> 00:26:07,290
+المريض بنلاقي إشي يعني very bright red area وهذه
+
+252
+00:26:07,290 --> 00:26:13,890
+زي ما هنا حاطين بتكون أكتر لأنه دخل بالـجينيتيك
+
+253
+00:26:13,890 --> 00:26:20,410
+Population معينة بتلاقيها أكتر في الأشكنازي «جود»
+
+254
+00:26:20,410 --> 00:26:28,150
+اليهود الأشكنازيين وبالتالي أحد أسباب الأمراض وهي
+
+255
+00:26:28,150 --> 00:26:33,990
+أيضًا اللي دخل بالـ Nervous System ففيه «Tysiac
+
+256
+00:26:33,990 --> 00:26:39,870
+Disease» بس فيه له Variations والـ Variationsالـ
+
+257
+00:26:39,870 --> 00:26:44,310
+يعني هنا الـ gene اللي affected فيه ألفة و Beta
+
+258
+00:26:44,310 --> 00:26:48,750
+chain هذا على chromosome 15 هذا على chromosome 5
+
+259
+00:26:48,750 --> 00:26:54,490
+وفيه activator تاني مطلوب فهنا الـ Alpha Beta
+
+260
+00:26:54,490 --> 00:27:04,090
+Chain والـ هنا الـ الـ ال substrate أظنني اللي هو
+
+261
+00:27:04,090 --> 00:27:09,620
+بدي يشتغل عليه وفيه ال activator وبصير عنديالـ
+
+262
+00:27:09,620 --> 00:27:18,040
+Problem في قضية الـ الـ يعني الـ Metabolic step
+
+263
+00:27:18,040 --> 00:27:22,400
+that is needed for normal function بحيث إنه هذا
+
+264
+00:27:22,400 --> 00:27:27,860
+اللي هو النوع من الـ Carbohydrate اللي هو الـ M
+
+265
+00:27:27,860 --> 00:27:33,460
+-acetylgalactosamine مع الـ Galactose فلما تكون
+
+266
+00:27:33,460 --> 00:27:38,130
+الـ Structure بهذا الشكلوبيصير الـ cleavage في هذا
+
+267
+00:27:38,130 --> 00:27:44,330
+الـ site نتيجة الـ enzyme هذا فأحياناً المرض اللي
+
+268
+00:27:44,330 --> 00:27:50,150
+بنشوفه زي الـ Carbohydrate Stroke Problem وزي الـ
+
+269
+00:27:50,150 --> 00:27:54,470
+Tysax Disease الـ
+
+270
+00:27:54,470 --> 00:28:01,230
+Classical Tysax ماشي بيصير عندي four base
+
+271
+00:28:01,230 --> 00:28:09,540
+insertion يعني حكيناتتذكروا لما يكون insertion و
+
+272
+00:28:09,540 --> 00:28:15,460
+deletion إذا الأمور فلفات ما راح يغير كتير المشكلة
+
+273
+00:28:15,460 --> 00:28:20,540
+ماشي إذا صار insertion لـ three nucleotides three
+
+274
+00:28:20,540 --> 00:28:26,940
+bases راح يقول يعني بزيد one amino acid أو بنقص
+
+275
+00:28:26,940 --> 00:28:31,880
+one amino acid مافي مشكلة المشكلة الكبيرة اللي هي
+
+276
+00:28:31,880 --> 00:28:37,490
+لما يكون عندنا one or twoالـ Total هنا Four يعني
+
+277
+00:28:37,490 --> 00:28:43,390
+زي كأنه One Base Insertion لما يصير One أو Two
+
+278
+00:28:43,390 --> 00:28:48,550
+بيسموه Frame Shift Mutation اللي هو يعني إنه كل
+
+279
+00:28:48,550 --> 00:28:55,670
+قراءة الـ Protein والـ DNA راح يخرب لأنه لما كله
+
+280
+00:28:55,670 --> 00:29:01,810
+إفدا راح يكون الأربعة راح تخلي كل ثلاثة لأن الـ
+
+281
+00:29:01,810 --> 00:29:07,680
+Trans cellأو الـ Ribosomal وTransferral RNA هو
+
+282
+00:29:07,680 --> 00:29:15,460
+ثلاثات الـ Codons لأن هنا أربعة راح يكون فيها
+
+283
+00:29:15,460 --> 00:29:22,040
+Frame Shift Mutation هذا راح تخرّب البروتين كله ما
+
+284
+00:29:22,040 --> 00:29:27,520
+راح يكون functional وراح يوقف وراح يكون useless
+
+285
+00:29:27,520 --> 00:29:34,300
+وبالتالي يصير عند المرضفهذه يعني الـ mechanism
+
+286
+00:29:34,300 --> 00:29:41,420
+لحالة تانية أو مرض تاني اسمه الـ Ticeps في
+
+287
+00:29:41,420 --> 00:29:46,480
+أمراض كثيرة للـ I-cell ما اندخل فيها، يعني مش راح
+
+288
+00:29:46,480 --> 00:29:53,280
+أدخل في كل شيء من النوع
+
+289
+00:29:53,280 --> 00:30:01,010
+الأمراض في حالة ثالثة اسمها الـ Homocystinuriaالـ
+
+290
+00:30:01,010 --> 00:30:08,730
+Homocysteine برضه من الـ الـ الـ Amino Acid وإله
+
+291
+00:30:08,730 --> 00:30:14,350
+دخل مع الـ Vitamin B12 اللي هو الـ
+
+292
+00:30:14,350 --> 00:30:22,810
+Cyanocopamolamine وإله دخل يعني في التجهيزلـ الـ
+
+293
+00:30:22,810 --> 00:30:29,350
+الـ الـ DNA replication وإيه دخل؟ يعني هو من الـ
+
+294
+00:30:29,350 --> 00:30:33,690
+Homocystein بالأخير بعد الـ Cytosine الـ Cytosine
+
+295
+00:30:33,690 --> 00:30:39,690
+اللي هو واحد من الـ Amino Acid وإيه دخل بالكوليت؟
+
+296
+00:30:39,690 --> 00:30:45,410
+وإيه دخل بالـ Vitamin B12؟ اللي هو راح يصير نفع
+
+297
+00:30:45,410 --> 00:30:52,780
+السيانات والـ Palamine وغيرهاأظن أني في حياتي شُفت
+
+298
+00:30:52,780 --> 00:31:00,200
+حالة واحدة بالأخير بيصير homocysteine urea بعد ما
+
+299
+00:31:00,200 --> 00:31:04,980
+يصير يعني increased الـ«هوموسيستيل» in the blood
+
+300
+00:31:04,980 --> 00:31:12,360
+بزيد كمان في الـexecration بالورين فنتيجة
+
+301
+00:31:12,360 --> 00:31:22,000
+المشكلة هذهكان أنا شوفت فعلاً فيه طفل يمكن عمره
+
+302
+00:31:22,000 --> 00:31:31,220
+تلت سنوات بس من ولادته صار عنده Renal stones
+
+303
+00:31:31,220 --> 00:31:34,320
+وبتكرار
+
+304
+00:31:34,320 --> 00:31:39,580
+يعني خلصوه من واحدة تصير عنده واحدة تانية ولحد ما
+
+305
+00:31:39,580 --> 00:31:44,200
+صوّنا له acidification of the urineلحد ما يساعد
+
+306
+00:31:44,200 --> 00:31:48,920
+أكتر في قضية تدويب الـ Homocysteine بحيث إنه منع
+
+307
+00:31:48,920 --> 00:31:58,400
+قضية إنه يصير يعني precipitation للـ Homocysteine
+
+308
+00:31:58,400 --> 00:32:04,500
+in the urine ويعملّك crystal ويعملّك Renal stones
+
+309
+00:32:04,500 --> 00:32:12,810
+وبعدين تدخله في Renal failure ومشاكل زي ذاتالفكرة
+
+310
+00:32:12,810 --> 00:32:20,070
+يعني هنا كمان قضية إنه if you know the metabolism
+
+311
+00:32:20,070 --> 00:32:25,470
+exact steps أو كيف الـ steps that are needed
+
+312
+00:32:25,470 --> 00:32:31,410
+أحياناً راح ناخدها أكتر في قضية ال treatment بعدين
+
+313
+00:32:31,410 --> 00:32:38,030
+كيف الواحد ممكن يسوي supplementation لأشياء يعني
+
+314
+00:32:38,030 --> 00:32:50,540
+الـ homocysteineفيه مشكلة اللي هو بـ الـ اسمه
+
+315
+00:32:50,540 --> 00:32:56,000
+«ستافايونين سينتيز» اللي هو الـ Intermediate Maker
+
+316
+00:32:56,000 --> 00:33:00,500
+نتيجة الـ Metabolism تبع الـHemocysteine يعني فيه
+
+317
+00:33:00,500 --> 00:33:05,030
+مشكلة في الـEnzyme هذهوهيكون بيستخدم فيها، يعني
+
+318
+00:33:05,030 --> 00:33:09,870
+حتى تتم الـ step هذه normally بيردوكسال بوسفيت
+
+319
+00:33:09,870 --> 00:33:16,190
+اللي هو جاي من ال .. اللي هو vitamin B6 اللي هو
+
+320
+00:33:16,190 --> 00:33:24,250
+الـ Birodioxin فالفكرة،
+
+321
+00:33:24,250 --> 00:33:29,210
+لأن هذا الـ enzyme صار فيه blockفبصير الـ
+
+322
+00:33:29,210 --> 00:33:35,690
+Homocystein أكتر بس إذا حطيت B6 supplementation
+
+323
+00:33:35,690 --> 00:33:41,590
+أكتر بيساعد الاستفادة من التم وبساعد حتى الـ
+
+324
+00:33:41,590 --> 00:33:47,270
+Abnormal enzyme وبالتالي بيخفف من أعراض المرضى،
+
+325
+00:33:47,270 --> 00:33:55,590
+فهذه أشياء زي ذلك في حالة من الـ enzyme آخر
+
+326
+00:33:58,930 --> 00:34:04,930
+ضروري لقضية تخبيط أحيانًا Inflammatory enzymes
+
+327
+00:34:04,930 --> 00:34:09,510
+that are released ففيه إيش اسمه Alpha-1
+
+328
+00:34:09,510 --> 00:34:15,950
+-antitrypsin عبارة عن إنزايم الـTrypsin اللي هو
+
+329
+00:34:15,950 --> 00:34:21,730
+عبارة عن زي الـPepsin وTrypsin هدولة اللي هو
+
+330
+00:34:21,730 --> 00:34:25,450
+digestive enzymes الـPepsin بالأسد بيكون
+
+331
+00:34:25,450 --> 00:34:32,140
+بالاستمتاعوالـ Trypsin اللي هو اللي بيكون من الـ
+
+332
+00:34:32,140 --> 00:34:38,680
+small intestine ويكون على higher pH يعني على الـ
+
+333
+00:34:38,680 --> 00:34:42,580
+alkaline environment بحاجة لـ alkaline environment
+
+334
+00:34:42,580 --> 00:34:47,680
+فالـ Trypsin إذا جوا الخلايا في الدم محل تاني
+
+335
+00:34:47,680 --> 00:34:54,700
+damaging يعني هو بيخرّب البروتينات وبيكسبها هو الـ
+
+336
+00:34:54,700 --> 00:34:59,500
+digestive enzymeففي عندنا إنزال أن ربنا حطه فينا
+
+337
+00:34:59,500 --> 00:35:05,040
+دا قضية الـ Alpha-1-Antitrypsin هو أحيانًا بيكون
+
+338
+00:35:05,040 --> 00:35:11,020
+deficient الـdeficiency هذه راح تسبب إنه الإنسان
+
+339
+00:35:11,020 --> 00:35:17,760
+هذا يصير عنده مشكلة في قضية إنه معرّف للاتهابات
+
+340
+00:35:17,760 --> 00:35:23,280
+الرئتين مبتلف بالرئتين ويصير عنده الاشي بكله
+
+341
+00:35:23,280 --> 00:35:29,190
+انفزيمةأو Bronchiectasis أو يعني كلفت الرياتين
+
+342
+00:35:29,190 --> 00:35:36,490
+بنسميه انتزينة فالملاحظ
+
+343
+00:35:36,490 --> 00:35:42,170
+هنا إن طبعاً أي مشاكل في الرياتين من أهم الأسباب
+
+344
+00:35:42,170 --> 00:35:49,990
+مرات كثيرة قضية التدخين التدخين مضر جداً وهنا
+
+345
+00:35:49,990 --> 00:35:58,610
+بحاول أعطيكم تصورفأهمية إنه إذا في إنسان عنده هذا
+
+346
+00:35:58,610 --> 00:36:04,030
+النوع من المشاكل أو يعني هو الأصل حتى لو ما عندهوش
+
+347
+00:36:04,030 --> 00:36:17,490
+الأصل الواحد يشوف يعني قضية إنه أحسن ما يدخلش فالـ
+
+348
+00:36:17,490 --> 00:36:23,850
+Alpha-1-Antitrypsin فيه الـO2الـ Alleles فيه إشي
+
+349
+00:36:23,850 --> 00:36:27,990
+بيقولوله الـ M اللي هو Normal والـ Z اللي هو الـ
+
+350
+00:36:27,990 --> 00:36:35,270
+Abnormal فاللي بيكون عنده ZZ بيكون معرض كتير إنه
+
+351
+00:36:35,270 --> 00:36:45,990
+يصير عنده تلت بريتين وهنا بيبينولهإنه يعني هذه
+
+352
+00:36:45,990 --> 00:36:52,910
+الدراسة بالذات فيها يعني
+
+353
+00:36:52,910 --> 00:36:58,390
+على قضية الوفيات وبالتالي الـSurvival هنا فهنا
+
+354
+00:36:58,390 --> 00:37:03,570
+بيفرجونا إنه لما نكون إنسان Smoker وعنده
+
+355
+00:37:03,570 --> 00:37:10,290
+Limitations على عمر مثلا هنا دخلنا 50% على عمر
+
+356
+00:37:10,290 --> 00:37:14,910
+الأربعين سنة بتوقفطبعًا، بتكون المشاكل قبلها
+
+357
+00:37:14,910 --> 00:37:23,410
+والمشاكل تلريتين بتكون مزمنة وقديمة ومستمرة تكرار
+
+358
+00:37:23,410 --> 00:37:30,610
+التهابات وإدوات تلف تلريتين وجزء من الصورة يعني
+
+359
+00:37:30,610 --> 00:37:35,910
+إذا فيه إشي بدي أكم تتذكرونه لبعدين إن شاء الله
+
+360
+00:37:35,910 --> 00:37:41,730
+لما نصيروا طباء وخصائين وكذاإنه ذات الـ Alpha-1
+
+361
+00:37:41,730 --> 00:37:49,510
+-antitrypsin جيني الأنومالي يكون التلف في الـ
+
+362
+00:37:49,510 --> 00:37:58,430
+lower part of the lungs يعني في مثلا الـ
+
+363
+00:37:58,430 --> 00:38:03,610
+tuberculosis وبتلافى الأجزاء العلوية من الـ lungs
+
+364
+00:38:03,610 --> 00:38:08,350
+هي اللي فيها مشاكل أكتر أما هنا زي ما أنتم شايفين
+
+365
+00:38:08,350 --> 00:38:15,250
+هناهي أشياء غير طبيعية طبعاً الـ «تستكتري» هذه
+
+366
+00:38:15,250 --> 00:38:21,130
+بيقول فيها «hyperinflation» يعني الرياتين مضخمات
+
+367
+00:38:21,130 --> 00:38:26,110
+أو الـ «diaphragm» بدل ما واحد بيشوفه بشكل سليم
+
+368
+00:38:26,110 --> 00:38:34,670
+بيشوفه flattened يعني مش زي قبة مضغوط ومدفوق لتحت
+
+369
+00:38:35,420 --> 00:38:39,640
+فهذه تغيرات وإنه أكتر التغيرات هي في المنطقة
+
+370
+00:38:39,640 --> 00:38:45,900
+السفلية من نظريتيها فهذه حالة اسمها Alpha-1
+
+371
+00:38:45,900 --> 00:38:52,520
+-Antitrypsin Deficiency ويعني
+
+372
+00:38:52,520 --> 00:38:58,720
+بتكون فيها مشكلة في أسئلة سهل الأمور يعني إحنا
+
+373
+00:38:58,720 --> 00:39:04,370
+بدنا هيك الـMajor Things بس يعني اللي بهمنيإنه
+
+374
+00:39:04,370 --> 00:39:12,030
+يعني الواحد لما يشوف مرض
+
+375
+00:39:12,030 --> 00:39:17,990
+بهذا الطريقة وكيف بيأثر على هذا الإشي يتخيل الواحد
+
+376
+00:39:17,990 --> 00:39:24,170
+إنه فيه metabolic pathway متابوليك إنزاين بيصير
+
+377
+00:39:24,170 --> 00:39:29,750
+فيه مشكلة بالأخير بنتج عنه المرض ماشي؟ فيها سؤال
+
+378
+00:39:29,750 --> 00:39:31,370
+إن شاء الله الأمور واضحة
+
+379
+00:39:38,100 --> 00:39:46,440
+الـ تمام إن شاء الله يا دكتور طيب في حالة اسمها
+
+380
+00:39:46,440 --> 00:39:54,920
+Porphyria الـ Porphyria مرض نتيجة
+
+381
+00:39:54,920 --> 00:40:04,100
+خلل الـ metabolism تبع الـ hem part أو الـ
+
+382
+00:40:04,100 --> 00:40:16,800
+hemoglobinإحنا إذا بنتذكر الـ….يعني الـHeme اللي
+
+383
+00:40:16,800 --> 00:40:21,740
+هو الـPyrrole
+
+384
+00:40:21,740 --> 00:40:26,000
+Ring اللي بيكون فيها الحديد اللي بتمسك الـOxygen
+
+385
+00:40:26,000 --> 00:40:27,700
+وجزء من الـHemoglobin
+
+386
+00:40:29,780 --> 00:40:36,220
+بدأت تصنع بالأول بطريقة معينة اللي هي إنه
+
+387
+00:40:36,220 --> 00:40:42,480
+الـGlycine أو سكسينالكوينزين A مع ALA اللي هو
+
+388
+00:40:42,480 --> 00:40:48,900
+Alpha-Hydelta
+
+389
+00:40:48,900 --> 00:40:55,960
+-Delta-Aminolagulinic Acid، ماشي؟ فـSynthetic فهذا
+
+390
+00:40:55,960 --> 00:41:04,420
+الـEnzymeبيعطينا الـ ALA اللي بتحول للـ PDG وبعدين
+
+391
+00:41:04,420 --> 00:41:08,560
+بيعطينا الـ Hydroxy Methyl Biluene بيعطينا الـ
+
+392
+00:41:08,560 --> 00:41:14,000
+Heme وبصير بالعكس بعدين له degradation في قضية
+
+393
+00:41:14,000 --> 00:41:17,360
+ال...
+
+394
+00:41:17,360 --> 00:41:22,460
+بتحول بعدين بالاخير كمان لـBilirubin لما الـ Heme
+
+395
+00:41:22,460 --> 00:41:26,890
+يصير له degradationوتتحول إلى إيش اسمه «بيليردين»
+
+396
+00:41:26,890 --> 00:41:31,130
+وبعدين «بيليروبين» وكذا، هذه كل أمور يعني إن شاء
+
+397
+00:41:31,130 --> 00:41:35,390
+الله أكيد أنتم بالـBiochemistry أخدتوها وعلى الأقل
+
+398
+00:41:35,390 --> 00:41:41,530
+بتعرفوا عنها وبتعرفوا تقريبا شو هي فالـ
+
+399
+00:41:41,530 --> 00:41:44,950
+Intermittent
+
+400
+00:41:44,950 --> 00:41:49,470
+Porphyria هي من الأمراض Acute Intermittent
+
+401
+00:41:49,470 --> 00:41:58,610
+Porphyria عبارة عن يعني إنسانفي لها Variations
+
+402
+00:41:58,610 --> 00:42:04,710
+كثيرة في بعضها بيعطي طفح على الجلد و Skin Rashes
+
+403
+00:42:04,710 --> 00:42:11,810
+إلى طريقة معينة بعضها بيعطيك هو من أسباب الـ Acute
+
+404
+00:42:11,810 --> 00:42:17,150
+Abdomen Medical Acute Abdomen يعني كيف الواحد إذا
+
+405
+00:42:17,150 --> 00:42:23,470
+فجأة بطنه بيصير يوجعه بيصير الواحد يشك في قضية إشي
+
+406
+00:42:23,470 --> 00:42:33,620
+جراحيزايدة قرحة فقبط في دار المعدو الـ12 مثلًا
+
+407
+00:42:33,620 --> 00:42:39,300
+التواء في الأمعاة Volulus مثلًا هذه كلها بنسميها
+
+408
+00:42:39,300 --> 00:42:43,360
+حالات جراحية
+
+409
+00:42:43,360 --> 00:42:51,370
+بينما مرات الوجع البطن ما بكون سببهحالة جراحية
+
+410
+00:42:51,370 --> 00:42:56,750
+بيكون سببه حالة باطنية يعني ما بيداعي لتدخل الجراح
+
+411
+00:42:56,750 --> 00:43:01,410
+فالتالي وعلى عكس مرات إذا الجراح بتدخل بيعمل مشكلة
+
+412
+00:43:01,410 --> 00:43:07,870
+فمثلها مثلًا Diabetic ketoacidosis اللي هي حالة
+
+413
+00:43:07,870 --> 00:43:12,730
+الانتفاع السكر كتير العالي مع نضارة الدم في اللي
+
+414
+00:43:12,730 --> 00:43:17,650
+عندهم نقص كامل في الـ Insulin الـ Type 1 diabetes
+
+415
+00:43:18,230 --> 00:43:22,310
+فهدولة لما يكونوا زي هذا بيكون فيه مشكلة كبيرة
+
+416
+00:43:22,310 --> 00:43:28,390
+Type 1 diabetes منها يكون acute abdomen يعني بيجيك
+
+417
+00:43:28,390 --> 00:43:32,230
+المريض بقلم شديد بالبطن وبيجي يشتك من هذا الموضوع
+
+418
+00:43:32,230 --> 00:43:36,390
+والحالة التانية من حالات أخرى اللي هي acute
+
+419
+00:43:36,390 --> 00:43:41,610
+intermittent porphyria بيصير برضه عنده الإنسان
+
+420
+00:43:41,610 --> 00:43:52,660
+مشكلة في إنه بيصير عنده وجع في البطنالـ… الفكرة
+
+421
+00:43:52,660 --> 00:44:00,380
+بدل واحد يتذكر الـEnzyme يعني على الأقل يعني
+
+422
+00:44:00,380 --> 00:44:06,660
+الـMajor One في قضية المسبب
+
+423
+00:44:06,660 --> 00:44:12,040
+لهذه الحالة ففي الحالة هنا اللي هو الـALA synthase
+
+424
+00:44:12,040 --> 00:44:22,680
+هو الـ… الـ…هو اللي بيعمل العراب هذه ولمّا يكون
+
+425
+00:44:22,680 --> 00:44:27,980
+فيه Enzyme مطلوب لموتابوليزم معينة الاشي اللي قبل
+
+426
+00:44:27,980 --> 00:44:32,400
+الـEnzyme هذا نتيجة خلل الـEnzyme راح يصير في
+
+427
+00:44:32,400 --> 00:44:36,060
+ارتفاع شديد وبالتالي يصير في عندنا accumulation
+
+428
+00:44:36,060 --> 00:44:40,860
+لهذا يعني احنا حكينا عن الفنع الألليل بالـBq هو
+
+429
+00:44:40,860 --> 00:44:48,700
+الـGlycine اللي دخل بالبرفيلفاللي هون اللي حاكينه
+
+430
+00:44:48,700 --> 00:44:52,600
+اللي هي قضية Post-Fertile Neurological Symptoms
+
+431
+00:44:52,600 --> 00:44:59,480
+هذه برضه من المشاكل عراض عصبية بعد البلوغ وهتكون
+
+432
+00:44:59,480 --> 00:45:07,800
+نتيجة مشكلة في الـAlanine الـAmino-Lidulinic Acid
+
+433
+00:45:07,800 --> 00:45:14,180
+Synthetic Defect ويصير هنا Glycine يعني الواحد إنه
+
+434
+00:45:14,180 --> 00:45:19,010
+كمان يعرفالـ Mechanism هذا والـ Enzyme هذا ولوين
+
+435
+00:45:19,010 --> 00:45:24,770
+بيشتغل وعلى شو بيشتغل بيقدر حد يحدد شو هو الـ
+
+436
+00:45:24,770 --> 00:45:31,490
+Amino acid اللي أنا بدي أدور عليه حتى أشوف ذا
+
+437
+00:45:31,490 --> 00:45:37,450
+مرتفع عشان أشخصها أيه الحالة وهنا زي ما حكينا مرات
+
+438
+00:45:37,450 --> 00:45:44,560
+يعني حكينا قبل شوية مثالاللي قبل الـ Alpha-1
+
+439
+00:45:44,560 --> 00:45:52,580
+Antitrypsin Deficiency اللي هو في المثال الـ
+
+440
+00:45:52,580 --> 00:45:55,700
+«هوماسيستينيوريا»
+
+441
+00:45:55,700 --> 00:46:01,280
+ناشي؟ كيف إن الـB6 هنا بيخفف الأمور و بيسهلها هنا
+
+442
+00:46:01,280 --> 00:46:04,640
+بدي أقولكم إن certain drugs and chemicals
+
+443
+00:46:04,640 --> 00:46:09,250
+الـFasting، السيام، بعض الـSteroidsThey
+
+444
+00:46:09,250 --> 00:46:13,770
+precipitate the disease بيصير إنه بيعملوا المشكلة
+
+445
+00:46:13,770 --> 00:46:18,130
+فزي ما كانت المثال اللي قبل إن الـ B6 بيكبّث
+
+446
+00:46:18,130 --> 00:46:23,150
+المشكلة هنا في أحيانًا أشياء بتزيد وفي أنتج كتيرة
+
+447
+00:46:23,150 --> 00:46:35,070
+في مجموعة أمراض يعني اللي هي Familial
+
+448
+00:46:35,070 --> 00:46:41,650
+Hypercholesterolemiaالـ Cholesterol يعني من الـ
+
+449
+00:46:41,650 --> 00:46:45,390
+«موليكولز» الضرورية في بناء الخلية من الأشياء
+
+450
+00:46:45,390 --> 00:46:50,690
+الضرورية للحياة موجودة في الطعام وبنأكلها بس كمان
+
+451
+00:46:50,690 --> 00:46:55,510
+الجسم بيصنعها بيستطيع أنه يصنعها فالـ Metabolism
+
+452
+00:46:55,510 --> 00:47:10,650
+تبعها يعني مهم وأهم يعني مجموعة أمراضنتج عن خلل
+
+453
+00:47:10,650 --> 00:47:16,030
+الكوليسترول هو قضية بالأخير تأثيراته على قضية
+
+454
+00:47:16,030 --> 00:47:20,630
+التصلب الشراين التصلب الشراين من أشع الأمراض
+
+455
+00:47:20,630 --> 00:47:26,770
+الحالية اللي هو مع الـ Process أو الـ Pathogenic
+
+456
+00:47:26,770 --> 00:47:30,870
+Process of Atherosclerosis الـ Atherosclerosis
+
+457
+00:47:30,870 --> 00:47:34,510
+اللي دخل أحيانًا كتير بقضية الـ
+
+458
+00:47:36,480 --> 00:47:40,500
+الضغط والسكري وطبعًا استفاق الدهون وهذا قصد
+
+459
+00:47:40,500 --> 00:47:45,360
+الـMajor Risk Factors زائد فيه تأثيرات Genetic
+
+460
+00:47:45,360 --> 00:47:52,720
+وFamilial وSmoking وMale Sex وغيرهم وغيرهم فالـ
+
+461
+00:47:52,720 --> 00:47:57,360
+Hypercholesterolemiaيعني الأرقام اللي عادة نتكلم
+
+462
+00:47:57,360 --> 00:48:00,440
+عنها طبعاً إلا دخل بالـ Obesity والـ Sedentary
+
+463
+00:48:00,440 --> 00:48:04,880
+Lifestyle والـ Metabolic Syndrome اللي هو نتيجة
+
+464
+00:48:04,880 --> 00:48:10,060
+نمط الحياة الحديث ناس بطلت تمشي، بطلت تبدل حركة
+
+465
+00:48:10,060 --> 00:48:16,720
+ولا نشط عضلاتها وكذا فالـ Cholesterol مهم كثير
+
+466
+00:48:16,720 --> 00:48:21,140
+والـ Cholesterol الـ Major Risk Factor هو الـ
+
+467
+00:48:21,140 --> 00:48:24,500
+Total Cholesterol بس لنتذكر إن الـ Cholesterolاللي
+
+468
+00:48:24,500 --> 00:48:30,300
+هو أنواع اللي هما فيه الـ… الـBad Cholesterol اللي
+
+469
+00:48:30,300 --> 00:48:34,540
+هو Low Density Lipoprotein LDL واللي فيه الـHigh
+
+470
+00:48:34,540 --> 00:48:37,280
+Density Lipoprotein اللي هو الـProtective أو
+
+471
+00:48:37,280 --> 00:48:43,160
+الـكويس فيه كمان VLDL Very Low Density Lipoprotein
+
+472
+00:48:43,160 --> 00:48:49,800
+وفيه الـKylomicrons وفيه الـTriglycerides
+
+473
+00:48:49,800 --> 00:48:56,010
+كنوع تاني من الـLipidsضرورية للحياة وضرورية في
+
+474
+00:48:56,010 --> 00:49:00,290
+الجسم فالواحد
+
+475
+00:49:00,290 --> 00:49:05,590
+يعني ما عرفته لهذه الجوانب ضرورية كثير والواحد بده
+
+476
+00:49:05,590 --> 00:49:12,090
+يتذكر الـcycle of الـcholesterol في الـbody كيف
+
+477
+00:49:12,090 --> 00:49:16,270
+أنه بتبنى انتصاصه في الأمعات، في مناطق معينة إيش
+
+478
+00:49:16,270 --> 00:49:21,670
+اسمه الـkylomicron عبارة عن lipid globulin أو
+
+479
+00:49:21,670 --> 00:49:29,300
+lipidيعني شنطة Lipid موجودة من الـ «تم انتصاصها»
+
+480
+00:49:29,300 --> 00:49:35,780
+في الأمعاق وكيف أن الـLipid حتى ينص الجسم بالذات
+
+481
+00:49:35,780 --> 00:49:39,740
+الـEssential Fatty Acid والـEssential Lipid بدّوا
+
+482
+00:49:39,740 --> 00:49:44,760
+Metabolism مختلف ففي
+
+483
+00:49:44,760 --> 00:49:47,340
+مجموعة ناس بتلاقي عندهم «فميليا»
+
+484
+00:49:47,340 --> 00:49:51,260
+الـHypercholesterolemia بتكون أرقام الـ«كوليسترول»
+
+485
+00:49:51,260 --> 00:49:56,740
+very highطبعاً إحنا الـ Hypercholesterolemia جزء
+
+486
+00:49:56,740 --> 00:50:01,660
+من حتى سريريا ممكن واحد يشوف فيه زي ما إن شاء الله
+
+487
+00:50:01,660 --> 00:50:06,600
+تاخدوا في قضايا الطب السريري فيه اللي هو الـ Arcus
+
+488
+00:50:06,600 --> 00:50:12,340
+Lipidus والـ Xanthlasmas والـ Xanthomas عبارة عن
+
+489
+00:50:12,340 --> 00:50:17,220
+يعني بتشوف على المريض في عينيه حوالين الجسم على
+
+490
+00:50:17,220 --> 00:50:23,640
+الكوع أو على جسمه بتلاقي في عندهترسوبات دهنية،
+
+491
+00:50:23,640 --> 00:50:28,280
+ماشي؟ وهذه اللي دخل أنه يصير عند الواحد أفلسفلورية
+
+492
+00:50:28,280 --> 00:50:36,260
+فالـ Familial Form، ماشي؟ ونتيجة هذا الجزء منه
+
+493
+00:50:36,260 --> 00:50:46,120
+نتيجة فهمنا لـ Metabolism لكيفية الجسم بتعامل مع
+
+494
+00:50:46,120 --> 00:50:51,320
+الـLipids اللي بيمصها من الأمعانأحنا بنصب الأول
+
+495
+00:50:51,320 --> 00:50:55,400
+الـ «كايلو مايكرونز» وبعدين بتتحول لما ناخد منها
+
+496
+00:50:55,400 --> 00:51:00,700
+شوية كوليسترول أكتر بيصير الـDLDL وبعدين بيصير
+
+497
+00:51:00,700 --> 00:51:11,400
+الـLDL في كوليسترول أكتر الـLDL بتم إتصافه مع اللي
+
+498
+00:51:11,400 --> 00:51:17,370
+هو الـLDL ريسبتر على الخلاياوإنه فيه أبوبروتين
+
+499
+00:51:17,370 --> 00:51:23,270
+B100 اللي هو الـCholesterol Easter Core وبعدين
+
+500
+00:51:23,270 --> 00:51:26,710
+بيصير Internalization وبالتالي بنزل نسبة
+
+501
+00:51:26,710 --> 00:51:32,270
+الـCholesterol في الدم فبالنسبة
+
+502
+00:51:32,270 --> 00:51:38,070
+للفميلة الـHypercholesterolemia فيه أكثر من نوع
+
+503
+00:51:38,070 --> 00:51:42,410
+على أقل الـMajor ones أربعة طبعا دولة من
+
+504
+00:51:42,410 --> 00:51:46,860
+الـEuropean descentفي مثلًا الـItalian ومدينة
+
+505
+00:51:46,860 --> 00:51:51,100
+الـEastern من كيف بيشي ده في الصينيين، اشي في
+
+506
+00:51:51,100 --> 00:51:55,920
+السود، اشي في كده ودول الأنواع، اشي اللي دخل
+
+507
+00:51:55,920 --> 00:52:03,820
+الـLDL-Receptor أو الـApoprotein B100 أو الـARH
+
+508
+00:52:03,820 --> 00:52:10,920
+-Adapter Protein أو الـPCSK9-Protease بيصير يعني
+
+509
+00:52:10,920 --> 00:52:15,030
+loss of function أو gain of functionوفي الغالب هما
+
+510
+00:52:15,030 --> 00:52:18,310
+autosomal dominant إلا إذا بعض فيه أشياء autosomal
+
+511
+00:52:18,310 --> 00:52:25,350
+resistant الطبيعي يعني
+
+512
+00:52:25,350 --> 00:52:30,110
+إحنا الـ optimal cholesterol level بالmilligram
+
+513
+00:52:30,110 --> 00:52:35,450
+per deciliter الطبيعي لإنسان ماعنديهوش مشكلة ويعني
+
+514
+00:52:35,450 --> 00:52:39,190
+مش مريض بعيشي تاني مش خائفين من قضية
+
+515
+00:52:39,190 --> 00:52:44,460
+الـAtherosclerosis نقبل لحد الميتينإذا كان عند
+
+516
+00:52:44,460 --> 00:52:47,420
+الواحد one two risk factors الـ optimal يكون تحت
+
+517
+00:52:47,420 --> 00:52:53,180
+الـ 160 إذا فيه عنده مشكلة وانده صار تصلف شرايين
+
+518
+00:52:53,180 --> 00:52:57,500
+بدنا هي تحت الـ 130 فالفميلة الـ
+
+519
+00:52:57,500 --> 00:53:03,160
+hypercholesterolemia الـ homozygous one في الـ LDL
+
+520
+00:53:03,160 --> 00:53:09,600
+receptor عادةً بيكون حوالي 700 بينما إذا
+
+521
+00:53:09,600 --> 00:53:14,910
+heterozygous وصل 350الـ Normal Adult حاطينه لحد
+
+522
+00:53:14,910 --> 00:53:20,510
+الـ 120 يعني يمكن دراسات أجدد وكل مكان أنزل أحسن
+
+523
+00:53:20,510 --> 00:53:26,950
+ففي عائلات بتلاقي و بتلاقي عندهم مشكلة لأن الـ
+
+524
+00:53:26,950 --> 00:53:30,890
+cholesterol very high وبالتالي مع ال other risk
+
+525
+00:53:30,890 --> 00:53:35,450
+factors بتخلي ال atherosclerosis يصير بشكل سريع
+
+526
+00:53:35,450 --> 00:53:42,290
+إذا بتلاقي عيلة فيها جنفات
+
+527
+00:53:43,240 --> 00:53:49,960
+في القلب، جلطات على الدماغ، جلطات وتصلب شرايين
+
+528
+00:53:49,960 --> 00:53:54,640
+وحطوا شبكات ومشاكل زي هيك في جزء منه التدخين
+
+529
+00:53:54,640 --> 00:53:58,820
+والضغط السكري صحيح بس عامل مهم كتير الـ
+
+530
+00:53:58,820 --> 00:54:03,640
+Hypercholesterolemia بالذات Daphamelial وفيه الآن
+
+531
+00:54:03,640 --> 00:54:09,680
+يعني دراسات على قضية الـ Mutations اللي بتسببها
+
+532
+00:54:09,680 --> 00:54:16,650
+الـ إمتى بنفكر في الموضوع هذا؟جزء منه لما يكون الـ
+
+533
+00:54:16,650 --> 00:54:20,990
+cholesterol very high يعني زي لما تشوف رقم زي هاتف
+
+534
+00:54:20,990 --> 00:54:27,370
+700 وبعدين بسأل عن أهل المريض وأقاربه وشو أوضعهم،
+
+535
+00:54:27,370 --> 00:54:32,490
+إذا بلاقي إشي زي هاتف، بالغالب هذه المشكلة، فهنا
+
+536
+00:54:32,490 --> 00:54:38,950
+هاي مثال على level حكينا إنه الإنسان الطبيعي يعني
+
+537
+00:54:38,950 --> 00:54:45,820
+هو أنا حاطي 160، 120، 180كيف أن الـ… الـ… الـ…
+
+538
+00:54:45,820 --> 00:54:50,520
+الـHeterozygous بالأربعميات الـHomozygous
+
+539
+00:54:50,520 --> 00:54:57,020
+بالسبعمية يعني مع أن يعني حتى في ملاحظة للهدول
+
+540
+00:54:57,020 --> 00:55:03,180
+الـHyperlipidemia لما يكون لما
+
+541
+00:55:03,180 --> 00:55:11,140
+يكون الـLevel very very very high حتى يعني أحياناً
+
+542
+00:55:11,140 --> 00:55:15,850
+بنلاقي الظاهرة هذهوأحنا نسحب الدم بتلاقيك وانت
+
+543
+00:55:15,850 --> 00:55:24,370
+تسحب دم المريض بتلاقي الدم مش لونه طبيعي عضياء
+
+544
+00:55:24,370 --> 00:55:29,630
+كأنه حليبي صار يعني فعلا بتلاقي فيه دهون موجود
+
+545
+00:55:29,630 --> 00:55:37,310
+ازيادي وبتكون نتيجة مشكلة هذا الموضوع فالـ Low
+
+546
+00:55:37,310 --> 00:55:41,010
+-Density Lipoprotein له
+
+547
+00:55:43,510 --> 00:55:49,150
+Different forms of mutations والموضوع اللي دخل
+
+548
+00:55:49,150 --> 00:55:54,310
+بالـ Familial hypercholesterolemia وإلها أنواع
+
+549
+00:55:54,310 --> 00:56:04,350
+وأشكال وكذا بد الواحد يكون يعرف عنها الأنواع
+
+550
+00:56:04,350 --> 00:56:11,130
+المختلفة يعني بشكل عام هذا المشكلة
+
+551
+00:56:12,860 --> 00:56:19,060
+في حالة أخرى اسمها «cystic fibrosis» «cystic
+
+552
+00:56:19,060 --> 00:56:30,440
+fibrosis» يعني برضه اللي هو في الغالب «autosomal
+
+553
+00:56:30,440 --> 00:56:33,640
+recessive»
+
+554
+00:56:33,640 --> 00:56:39,440
+«cystic fibrosis» حالة
+
+555
+00:56:40,800 --> 00:56:47,820
+هي من أسباب أو قريبة من الـ تشتركتي تقريبًا مع
+
+556
+00:56:47,820 --> 00:56:52,700
+حكينا عن موضوع الـ Alpha-1-Antithepsin Deficiency
+
+557
+00:56:52,700 --> 00:56:58,080
+بتسبب برضه مشكلة بالنسبة للريعتين مبكرة يعني اللي
+
+558
+00:56:58,080 --> 00:57:04,400
+بيكون إنسان أو طفل أو عائلة عندها أفراد بتصير
+
+559
+00:57:04,400 --> 00:57:10,370
+عندهم تكرار في حدوث انتهاب الريعتينبكون مشكلة في
+
+560
+00:57:10,370 --> 00:57:18,430
+قضية الـ… بيكون قضية أحيانًا الـcystic fibrosis
+
+561
+00:57:18,430 --> 00:57:25,930
+الـ… الـcystic fibrosis بتعمل مشكلة في الرئتين
+
+562
+00:57:25,930 --> 00:57:32,270
+نتيجة تكرار الجهد وممكن تعطينا مشكلة يعني تخراب في
+
+563
+00:57:32,270 --> 00:57:38,050
+الرئتين وبتعمل مشكلة إنهحتى بالنسبة لو وظيفة
+
+564
+00:57:38,050 --> 00:57:42,390
+البنكرياس بيصير فيها مشكلة لو بيصير malabsorption
+
+565
+00:57:42,390 --> 00:57:49,450
+بيصير مشاكل سوء هضم growth retardation بيصير مشكلة
+
+566
+00:57:49,450 --> 00:57:59,990
+فيها لما درسوا الموضوع فيه very important يعني
+
+567
+00:57:59,990 --> 00:58:05,850
+بالأخير geneاللي هو سميناها بعدين «cystic fibrosis
+
+568
+00:58:05,850 --> 00:58:11,610
+transporter receptor gene» اللي هو «CFTR» هذا
+
+569
+00:58:11,610 --> 00:58:21,830
+عبارة عن موليكيول كبير وظيفته إنه بيعمل exchange
+
+570
+00:58:21,830 --> 00:58:27,930
+between الصوديوم والبوتاسيوم والكالسيوم حوالين على
+
+571
+00:58:27,930 --> 00:58:34,150
+الـ cell wall يعني هواللي بيكون بالأخير بتحكم في
+
+572
+00:58:34,150 --> 00:58:41,650
+قضية ادخال وإخراج الـ… هدولة الـ… الـIons
+
+573
+00:58:41,650 --> 00:58:48,490
+الـPositive Ions من الـCell فالـ…
+
+574
+00:58:48,490 --> 00:58:54,350
+زي ما هم رسمينكم هنا، الـCFTR وحطينا Capital،
+
+575
+00:58:54,350 --> 00:59:01,450
+الـCapital هي للـGene، ناشي؟ فعطينا الـCFTRبالأول
+
+576
+00:59:01,450 --> 00:59:07,550
+الـ In-between اللي هو الـ RNA Messenger RNA
+
+577
+00:59:07,550 --> 00:59:18,350
+وبعدين بيعطينا البروتين الـ CFTR جين له Exons فالـ
+
+578
+00:59:18,350 --> 00:59:27,270
+Exons 23 Exons ماشي الـ Exons هم اللي بدخلوا
+
+579
+00:59:27,270 --> 00:59:31,780
+التركيبالبروتين والـ introns in between are
+
+580
+00:59:31,780 --> 00:59:38,220
+removed at the stage of the messenger RNA البروتين
+
+581
+00:59:38,220 --> 00:59:48,220
+الأخير هو Complex يعني هو بوابة لتنقل
+
+582
+00:59:48,220 --> 01:00:00,470
+الـ ions in the cell membrane فبيجي تركيبه هيفالـ
+
+583
+01:00:00,470 --> 01:00:05,830
+Cystic Fibrosis يعني إيه دخل بالـ Lungs إيه دخل
+
+584
+01:00:05,830 --> 01:00:11,670
+بالـ Pancreas و بالـ GI الفحص السريري عندنا بتذكر
+
+585
+01:00:11,670 --> 01:00:17,490
+أستاذ إيه اللي كنا في الكويت كان يقول شخصة Cystic
+
+586
+01:00:17,490 --> 01:00:24,250
+Fibrosis لأنه أم الطفل مولود حديد بتقول يا دكتور
+
+587
+01:00:24,250 --> 01:00:33,300
+عرق الطفل مالح كتيرشايف إن ملوحته زايد كثير كانت
+
+588
+01:00:33,300 --> 01:00:38,780
+اللي لما إنها بيسموه chloride sweat test يعني
+
+589
+01:00:38,780 --> 01:00:44,580
+إبارة عن test إنه بيخلوا بيبقوا يعني بيحطوا زي
+
+590
+01:00:44,580 --> 01:00:49,840
+منشف على منشف غير منفذ على الطفل و بيخلوه يقرأ
+
+591
+01:00:51,090 --> 01:00:55,750
+وبيجمعوا العرق تبعه بيشوفوا مستوى الملح فيه وهذا
+
+592
+01:00:55,750 --> 01:01:01,690
+بيسموه chloride sweat test أو sweat chloride test
+
+593
+01:01:01,690 --> 01:01:06,410
+إذا أكثر من ستين أقل من ستين قولوا أرقام وبنعرف
+
+594
+01:01:06,410 --> 01:01:16,420
+عنها فالـعبارة عن Complex Protein اللي دخل بالـ
+
+595
+01:01:16,420 --> 01:01:24,840
+Cell Membrane بالأخير بتحكم بإدخال وإخراج الـ Ions
+
+596
+01:01:24,840 --> 01:01:29,540
+from and into the cell فاللي دخل بالـ Secretions
+
+597
+01:01:29,540 --> 01:01:34,520
+واللي دخل في وظائف الرئتين والبكريات فهنا في محالة
+
+598
+01:01:34,520 --> 01:01:40,910
+اسمها Cystic Fibrosis وبيحاولوا يساعدوهموبحاولوا
+
+599
+01:01:40,910 --> 01:01:47,530
+يعني يدرسوا الموضوع هذا في حالات أخرى زي مثلًا الـ
+
+600
+01:01:47,530 --> 01:01:51,550
+Duchene Muscular Dystrophy الـ Duchene عبارة عن
+
+601
+01:01:51,550 --> 01:02:00,430
+مرض في تركيب من العضلات بيكون حجم العضلات كبير بس
+
+602
+01:02:00,430 --> 01:02:05,090
+ضعيف يعني بتحسه يسمونه pseudo-hypertrophy pseudo
+
+603
+01:02:05,090 --> 01:02:11,950
+يعني كابل يعني بيكونفي ضعف العضلات ويمكن تكلمنا
+
+604
+01:02:11,950 --> 01:02:17,410
+مرة من قبل عنه تبارعًا الـ protein مطلوب للـ
+
+605
+01:02:17,410 --> 01:02:24,670
+action of the muscles واسمه دول الأمراض
+
+606
+01:02:28,410 --> 01:02:32,630
+يعني الـGenetic وهكون إلها أكتر من نوع وفيه إشي
+
+607
+01:02:32,630 --> 01:02:37,870
+اسمه «فكر» «Muscular Dystrophy» أخف وبيبدأ بشكل
+
+608
+01:02:37,870 --> 01:02:44,630
+متأخر عن الـClassical «دوشين» اتكلمنا عنهم وقلناوا
+
+609
+01:02:44,630 --> 01:02:49,130
+إله فيه مشاكل
+
+610
+01:02:49,130 --> 01:02:55,790
+وفيه أكتر من نوع قضية الـ«دوشين»في الـ
+
+611
+01:02:55,790 --> 01:03:00,390
+Achondroplasia أو أستوجينيسيا انبرفكتا برضه من
+
+612
+01:03:00,390 --> 01:03:09,730
+الأمراض الأخرى في العبام وأستوجينيسيا
+
+613
+01:03:09,730 --> 01:03:14,370
+انبرفكتا اللي هو فيه مشكلة الـ Type 1 collagen
+
+614
+01:03:14,370 --> 01:03:21,610
+genes برضه يعني هترجعلكم مرة صورة عنها هتذكرها
+
+615
+01:03:21,610 --> 01:03:28,710
+لأنهلما كنت في التدريب السريري وانا طالب كان عندنا
+
+616
+01:03:28,710 --> 01:03:33,050
+طفل أو مش طفل هي امرأة كبيرة بالعمر كان عمرها
+
+617
+01:03:33,050 --> 01:03:38,890
+حوالي يعني تلاتين سنة بس على wheelchair حجمها قدر
+
+618
+01:03:38,890 --> 01:03:44,530
+طفل عمره سنة، سنتين، قزم كثير وفيه كسور في الإباعم
+
+619
+01:03:44,530 --> 01:03:50,110
+وفيه كسور فيه هشاشة وفيه مشكلة والـSclera are blue
+
+620
+01:03:51,570 --> 01:03:56,450
+حوالين المنطقة الملونة في العين بيزرقاق وهي
+
+621
+01:03:56,450 --> 01:04:00,590
+Osteogenesis Imperfecta واللي هي أكتر من نوعها من
+
+622
+01:04:00,590 --> 01:04:06,450
+الأمراض بالنسبة للـ College بدناهاش تفاصيل الأمور
+
+623
+01:04:06,450 --> 01:04:13,330
+هذه وفيها مشاكل كتيرة المجموعة
+
+624
+01:04:13,330 --> 01:04:19,750
+الأخيرة من الأمراض هم أيضًا من الأمراض اللي دخل
+
+625
+01:04:19,750 --> 01:04:25,030
+بالجهاز العصبياللي هما Alzheimer Disease الألزايمر
+
+626
+01:04:25,030 --> 01:04:30,710
+هو حالة نتيجة الـ…
+
+627
+01:04:30,710 --> 01:04:34,970
+الـ… الـ… يعني بدنا نسميه «pre-senile dementia» هي
+
+628
+01:04:34,970 --> 01:04:42,170
+حالة الخرف المبكر كيف إن الإنسان يصير يخرف أو يعني
+
+629
+01:04:42,170 --> 01:04:47,350
+عنده خرف اللي هو تناقص في قدراته العقلية في ذكاءه،
+
+630
+01:04:47,350 --> 01:04:55,360
+في ذاكرته، فيالتعامل هو فيه بتأثر صراحة يعني معه
+
+631
+01:04:55,360 --> 01:05:01,760
+ازدياد عمار الناس تصبح أي ظاهرة أو مشكلة كبيرة
+
+632
+01:05:01,760 --> 01:05:08,220
+بيصير يعني ذا كبار بالعمر يعني يعني من أهم الأمراض
+
+633
+01:05:08,220 --> 01:05:14,740
+الأشياء اللي بتخوف وبيصير الواحد يعني عنده متكاسب
+
+634
+01:05:14,740 --> 01:05:22,700
+بالنسبة لقدرات العقليةفالفكرة إنه الإنسان يعني ضعف
+
+635
+01:05:22,700 --> 01:05:28,500
+شديد في القدرات العقلية متوقع على عمره كان فوق
+
+636
+01:05:28,500 --> 01:05:34,940
+الـ85، 90، بعد هيك متوقع أن يكون فيه مشكلة في
+
+637
+01:05:34,940 --> 01:05:40,240
+القدرات العقلية بالإضافة لقدرات الجسمانية العضلية
+
+638
+01:05:40,240 --> 01:05:47,410
+والطول والحركة وكذا، بتصير فيه مشاكلأما لما تصير
+
+639
+01:05:47,410 --> 01:05:52,510
+هذه الأمور بشكل مبكر على سن الأربعين أو الخمسين أو
+
+640
+01:05:52,510 --> 01:05:57,690
+الستين هذا بنسميه «الزايمرد» وتكون «resinyl
+
+641
+01:05:57,690 --> 01:06:08,990
+dementia» لاحظنا أن أحيانًا هذه بتكون
+
+642
+01:06:08,990 --> 01:06:19,580
+عبارة عن كثير منهافيه ترسُبات من عبارة عن الـ
+
+643
+01:06:19,580 --> 01:06:25,420
+«بروتينز» زي الـ Amyloid وبتكون ترسُبات في الدماغ
+
+644
+01:06:25,420 --> 01:06:32,200
+وفيه أشياء بيكون مش طبيعية فلقينا بعدين فيه
+
+645
+01:06:32,200 --> 01:06:37,020
+certain genetic mutations وهي بعضها autosomal
+
+646
+01:06:37,020 --> 01:06:41,280
+dominant وفيه أشياء بتكون الـinheritance تبعتها
+
+647
+01:06:41,280 --> 01:06:47,940
+مختلفةهنا يعني بيعطوا أنثى على إيش يسموه Beta
+
+648
+01:06:47,940 --> 01:06:52,580
+-amyloid precursor للبروتين هذه في فميليا
+
+649
+01:06:52,580 --> 01:06:57,240
+الـAlzheimer disease وبيكون نتيجة Mutations في
+
+650
+01:06:57,240 --> 01:07:02,200
+Enzymes معينين اللي دخل بالـMetabolism حيث إنه
+
+651
+01:07:02,200 --> 01:07:05,240
+بيصير لنا Precipitation للـamyloid هذا بالدمعة
+
+652
+01:07:05,240 --> 01:07:09,800
+وبتعطينا اللي
+
+653
+01:07:09,800 --> 01:07:12,280
+هو الـAlzheimer
+
+654
+01:07:14,990 --> 01:07:19,310
+Apolipoprotein E Polymorphism برضه هذا واحد من الـ
+
+655
+01:07:19,310 --> 01:07:24,550
+mechanisms للـ Familial Alzheimer Disease وفي
+
+656
+01:07:24,550 --> 01:07:31,050
+أنواع كثيرة الـ mitochondrial DNA فيه لأمراض برضه
+
+657
+01:07:31,050 --> 01:07:38,550
+كثيرة ذكروا الـ mitochondrial أنه حسب ممكن
+
+658
+01:07:38,550 --> 01:07:44,360
+dominant ممكن recessive بس الفكرة أنهبتم نقله من
+
+659
+01:07:44,360 --> 01:07:50,840
+خلال الأم فقط يعني لو ذكر مصاب ماشي و عنده إصابة
+
+660
+01:07:50,840 --> 01:07:55,200
+بس ما بعطي ولاده و بناته إنما الأنثى فقط هي اللي
+
+661
+01:07:55,200 --> 01:07:59,260
+بتعطي بسبب إن الـ mitochondria يتم نقل عن طريق
+
+662
+01:07:59,260 --> 01:08:07,240
+الأوفا فقط فاللي سموه اللي
+
+663
+01:08:07,240 --> 01:08:13,940
+هو الـ lipare retinopathy أي شيء دخل بالعيونفي
+
+664
+01:08:13,940 --> 01:08:23,760
+إبنيء الـ Lactic Acidosis على Encephalopathy على
+
+665
+01:08:23,760 --> 01:08:28,860
+Stroke Life Picture يعني الإنسان شكله بيجي جلطة
+
+666
+01:08:28,860 --> 01:08:33,580
+ويقول فيه مشكلة Serendomyopathy
+
+667
+01:08:37,850 --> 01:08:41,490
+يعني فيه بتعطي مشاكل كثيرة نتيجة الـMitochondrial
+
+668
+01:08:41,490 --> 01:08:47,710
+Disease الـI لها أنواع كثيرة وزي ما انتوا شايفين
+
+669
+01:08:47,710 --> 01:08:51,810
+يعني أهم شي فيها اللي هي إنه الـInheritance
+
+670
+01:08:51,810 --> 01:09:01,170
+maternal فقط ما بيقول فيه شو اسمه يكون دخل بالنسبة
+
+671
+01:09:01,170 --> 01:09:07,420
+للأب يعطي الحالة هذا يعني مش غلط دلواحد بيشوفيعني
+
+672
+01:09:07,420 --> 01:09:12,480
+إنسان عنده بالذات ضعف عضلات اشتلال في العصاب بشكل
+
+673
+01:09:12,480 --> 01:09:19,980
+يعني ليش أقول مميز أو غريب بالذات لما يكون فيه
+
+674
+01:09:19,980 --> 01:09:30,140
+تاريخ عالي يجب أن يكون أحد يتذكر هذه الأشياء فيه
+
+675
+01:09:30,140 --> 01:09:38,470
+كمان أمراض وحالات ثانية يكون الـ Mechanismقضية مش
+
+676
+01:09:38,470 --> 01:09:41,610
+في الـ Coding DNA يعني احنا كثير من الأشياء اللي
+
+677
+01:09:41,610 --> 01:09:46,570
+اتكلمنا عنها عبارة عن أمثلة عن أنه الـ Protein
+
+678
+01:09:46,570 --> 01:09:49,930
+بيكون فيه مشكلة نتيجة أنه الـ Gene فيه مشكلة
+
+679
+01:09:49,930 --> 01:10:01,770
+أحيانًا في أمراض وحالات بيكون المشكلة في الـ يعني
+
+680
+01:10:01,770 --> 01:10:12,170
+بعد ما تصير قضيةالـ يعني الحالات هنا بتكون repeat
+
+681
+01:10:12,170 --> 01:10:19,270
+اللي هو Tri-nucleotide repeat disease اللي هي إنه
+
+682
+01:10:19,270 --> 01:10:24,990
+بيصير خلل على مستوى أوضح على مستوى الـRNA ففيه
+
+683
+01:10:24,990 --> 01:10:27,650
+Myotonic Dystrophy وHuntington disease
+
+684
+01:10:27,650 --> 01:10:33,310
+وFrederick's ataxia وFragileالـ X-Syndrome العادية
+
+685
+01:10:33,310 --> 01:10:40,010
+والـ Tremor Attack Syndrom يعني عبارة عن ملاحظة أن
+
+686
+01:10:40,010 --> 01:10:44,190
+أهم شيء تقريبًا العصاب هي اللي لدينا مشكلة فيها
+
+687
+01:10:44,190 --> 01:10:49,310
+والـ Huntington's Disease مرعب يعني للإنسان
+
+688
+01:10:49,310 --> 01:10:52,950
+ولعائلة بتاعته والله يحمينا مش من الأشياء اللي
+
+689
+01:10:52,950 --> 01:11:01,030
+كتير لدينا منها مشاكل أتأمل أن أكون يعني غطيتبشكل
+
+690
+01:11:01,030 --> 01:11:10,790
+يعني بأعطيكم هيك بعض المعلومات بشكل مفيد لإيش
+
+691
+01:11:10,790 --> 01:11:19,070
+أمراض من هذه الناحية وإذا حد عنده أسئلة يسأل
+
+692
+01:11:19,070 --> 01:11:26,470
+أنا يعني بعد قليل عند التزام ثاني، محاضرة ثانية
+
+693
+01:11:27,020 --> 01:11:34,080
+فهذا الـ Spectrum أو هذه الأمثلة
+
+694
+01:11:34,080 --> 01:11:40,460
+اللي بيحاولوا يفرجوكم فيها بدايةً إيش الخلق في
+
+695
+01:11:40,460 --> 01:11:45,380
+الجيل، على إيش المأثر، وفي الأخير كيف بعطينا المرض
+
+696
+01:11:45,380 --> 01:11:48,960
+لأن
+
+697
+01:11:48,960 --> 01:11:57,640
+الـ «هيس» قال أنا بتوقع السؤال راح يكون علىمطلوب،
+
+698
+01:11:57,640 --> 01:12:04,080
+مش مطلوب، مش عارف إيه، إيش، كده يعني لما الواحد
+
+699
+01:12:04,080 --> 01:12:11,960
+يكون على اطلاع على كيف هذه الحالات بتصير وشو الـ
+
+700
+01:12:11,960 --> 01:12:18,260
+Mechanism تبعتها وكيف بتكون بيكون الواحد إن شاء
+
+701
+01:12:18,260 --> 01:12:21,960
+الله طبيب ودكتور أحسن فيه أسئلة؟
+
+702
+01:12:24,620 --> 01:12:31,100
+كأنني شُفت إنه فيه الـ «تشات» أو الـ
+
+703
+01:12:31,100 --> 01:12:35,680
+«تشات» أنا
+
+704
+01:12:35,680 --> 01:12:44,960
+اللي بيهمني يعني هي أمور مش للحِطب بالذات الـ
+
+705
+01:12:44,960 --> 01:12:49,200
+«metabolic steps» أو كده بقدر ما إنه مثلًا نوعية
+
+706
+01:12:49,200 --> 01:12:53,160
+الـEnzymes اللي إيش هي، على أي شي بتشتغل، ما هو
+
+707
+01:12:53,160 --> 01:12:59,800
+اسم الـ«إنزايم»بقولّك على إيش بيشتغل يعني في نوع
+
+708
+01:12:59,800 --> 01:13:04,340
+الأنانين مثلًا «هيدروكسيلز» ولا «سينتيز» ولا إشي
+
+709
+01:13:04,340 --> 01:13:13,320
+يعني إيه دخل بالأماكن
+
+710
+01:13:13,320 --> 01:13:19,560
+التفرات؟ لأ، ما فيش حد ممكن يحفظ أماكن التفرات زي
+
+711
+01:13:19,560 --> 01:13:23,800
+ما حكيت في أمثلة كثيرة عدد التفرات كبير جدًا، هائل
+
+712
+01:13:23,800 --> 01:13:27,820
+جدًاالأخير كلهم بيخربوا نفس الـ Enzyme بطرق مختلفة
+
+713
+01:13:27,820 --> 01:13:32,780
+أو نفس البروتين بيخربوه بطرق مختلفة الـ Alzheimer
+
+714
+01:13:32,780 --> 01:13:39,300
+له ثمن كبير وممكن يكون مميت طبعاً يعني نفسه نفسه
+
+715
+01:13:39,300 --> 01:13:47,340
+الإنسان بعد يعني هو الإنسان فقط كجسم لأ يعني القلب
+
+716
+01:13:47,340 --> 01:13:52,120
+والريعتين بيشتغل جزء من الدماغ يعني بالـ Brain
+
+717
+01:13:52,120 --> 01:13:59,090
+Stem بتحكم بالأشياءاللي هي الضرورية، وهدولة بتبقى
+
+718
+01:13:59,090 --> 01:14:03,070
+شغالة، ما بتتأثر أما الـAlzheimer بيأثر على
+
+719
+01:14:03,070 --> 01:14:09,130
+إنسانية الإنسان على دماغه من ناحية الـHigher
+
+720
+01:14:09,130 --> 01:14:13,650
+Mental Functions الشخصية،
+
+721
+01:14:13,650 --> 01:14:24,760
+اللغة، الذكاء، التعامل الاجتماعي، كذاالإنسان يعني
+
+722
+01:14:24,760 --> 01:14:32,140
+بتمنى وبرغب دايما انه يكون مستقل يكون انه هو يعني
+
+723
+01:14:32,140 --> 01:14:41,420
+هو مستقل وهو يقدر يعمل يعيش بحياته أنا مضطر هسة
+
+724
+01:14:41,420 --> 01:14:47,820
+أترك ماشي و بنكمل يوم الأربعاء عشان أقول للعالمين
+
+725
+01:14:47,820 --> 01:14:54,600
+يعطيك ألف عفو يا دكتور أهلا و سهلانعم لأ هو خارج
+
+726
+01:14:54,600 --> 01:14:59,560
+المحاضرة خلاص مش مشكلة خير الله يعطيك ألف عفو يا
+
+727
+01:14:59,560 --> 01:15:03,840
+دكتور الله يحييكم أهلا وسهلا نشوفكم على خير ان شاء
+
+728
+01:15:03,840 --> 01:15:04,040
+الله
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/u_JvIjOn4A0_raw.json b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/u_JvIjOn4A0_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..ceade1e7ae797de8281e43005ca69df80ef0da53
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/u_JvIjOn4A0_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 2824, "start": 2.08, "end": 28.24, "text": "الـ Share أمورنا كويسة في شباب وداخلين أربعة لسه طيب نبدأ زي كل مرة في الأول في أسئلة على الأشياء اللي تم نقاشها من قبل في حد عنده سؤال في الوراقة", "tokens": [6027, 39184, 14945, 5551, 2304, 13063, 8315, 9122, 45865, 3794, 3660, 8978, 13412, 3555, 16758, 4032, 3215, 47283, 1211, 9957, 5551, 25513, 27884, 5296, 3794, 3224, 23032, 1829, 3555, 8717, 44510, 10721, 30767, 1829, 28242, 3714, 25720, 8978, 16247, 12610, 8978, 5551, 3794, 19986, 37977, 15844, 16247, 8592, 1829, 16606, 13672, 1829, 46811, 8717, 4587, 33599, 11296, 9154, 12174, 36150, 8978, 11331, 3215, 43242, 3224, 8608, 33604, 6027, 8978, 2423, 13063, 995, 28671], "avg_logprob": -0.13756334902466955, "compression_ratio": 1.5207100591715976, "no_speech_prob": 2.086162567138672e-06, "words": [{"start": 2.0800000000000027, "end": 3.2, "word": "الـ", "probability": 0.882080078125}, {"start": 3.2, "end": 3.88, "word": " Share", "probability": 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"end": 1301.5, "word": " يعني", "probability": 0.787841796875}, {"start": 1301.5, "end": 1302.76, "word": " اللي", "probability": 0.890625}, {"start": 1302.76, "end": 1303.4, "word": " هو", "probability": 0.93994140625}, {"start": 1303.4, "end": 1304.64, "word": " الـ", "probability": 0.963623046875}, {"start": 1304.64, "end": 1305.02, "word": " Amino", "probability": 0.7125244140625}, {"start": 1305.02, "end": 1305.4, "word": " acid", "probability": 0.53125}, {"start": 1305.4, "end": 1305.96, "word": " بتقلهم", "probability": 0.63262939453125}, {"start": 1305.96, "end": 1306.9, "word": " أكتر", "probability": 0.9686279296875}, {"start": 1306.9, "end": 1307.1, "word": " من", "probability": 0.99658203125}, {"start": 1307.1, "end": 1307.64, "word": " طريقة", "probability": 0.9912109375}, {"start": 1307.64, "end": 1308.98, "word": " للكتابة", "probability": 0.95947265625}, {"start": 1308.98, "end": 1309.88, "word": " فممكن", "probability": 0.9537760416666666}, {"start": 1309.88, "end": 1310.16, "word": " واحد", "probability": 0.987548828125}, {"start": 1310.16, "end": 1310.54, "word": " يكتب", "probability": 0.9102783203125}, {"start": 1310.54, "end": 1311.82, "word": " Phenylalanine", "probability": 0.7563720703125}, {"start": 1311.82, "end": 1313.98, "word": " كـ", "probability": 0.81982421875}, {"start": 1313.98, "end": 1314.42, "word": " Amino", "probability": 0.767578125}, {"start": 1314.42, "end": 1314.84, "word": " acid", "probability": 0.921875}, {"start": 1314.84, "end": 1315.48, "word": " يكتبه", "probability": 0.947265625}, {"start": 1315.48, "end": 1316.54, "word": " كامل", "probability": 0.9944661458333334}, {"start": 1316.54, "end": 1317.04, "word": " وفيه", "probability": 0.8619791666666666}, {"start": 1317.04, "end": 1317.48, "word": " بيحطوا", "probability": 0.90380859375}, {"start": 1317.48, "end": 1317.8, "word": " ثلاث", "probability": 0.916015625}, {"start": 1317.8, "end": 1318.3, "word": " أحرف", "probability": 0.9742838541666666}, {"start": 1318.3, "end": 1319.36, "word": " وفيه", "probability": 0.9371744791666666}, {"start": 1319.36, "end": 1320.1, "word": " بيرمزولهم", "probability": 0.9308268229166666}, {"start": 1320.1, "end": 1320.56, "word": " بحرف", "probability": 0.8238932291666666}, {"start": 1320.56, "end": 1321.22, "word": " واحد،", "probability": 0.785400390625}, {"start": 1321.22, "end": 1321.52, "word": " فيبقى", "probability": 0.7398681640625}, {"start": 1321.52, "end": 1322.02, "word": " الأخير", "probability": 0.7916666666666666}], "temperature": 1.0}, {"id": 50, "seek": 134986, "start": 1322.58, "end": 1349.86, "text": "إذا بالواحد بيرجع للجدول بيشوف شو الـ «R» بتمثل أنه Amino Acid ماشي و «W» Amino Acid تاني فاللي بيصير أنه بدل كده بيجي كده فبدي أقول في عندنا Substitution لـAmino Acid الـ408 هي الـLocation تبعة الـAmino Acid Substitution هذا", "tokens": [28814, 15730, 20666, 14407, 24401, 4724, 13546, 7435, 3615, 24976, 7435, 3215, 12610, 4724, 1829, 8592, 38688, 13412, 2407, 2423, 39184, 4657, 49, 5933, 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1325.04, "word": " بيشوف", "probability": 0.8194580078125}, {"start": 1325.04, "end": 1325.48, "word": " شو", "probability": 0.7568359375}, {"start": 1325.48, "end": 1326.28, "word": " الـ", "probability": 0.926025390625}, {"start": 1326.28, "end": 1326.62, "word": " «R»", "probability": 0.7295735677083334}, {"start": 1326.62, "end": 1327.32, "word": " بتمثل", "probability": 0.8804931640625}, {"start": 1327.32, "end": 1327.66, "word": " أنه", "probability": 0.8837890625}, {"start": 1327.66, "end": 1328.1, "word": " Amino", "probability": 0.6959228515625}, {"start": 1328.1, "end": 1328.64, "word": " Acid", "probability": 0.834228515625}, {"start": 1328.64, "end": 1329.7, "word": " ماشي", "probability": 0.8111979166666666}, {"start": 1329.7, "end": 1330.4, "word": " و", "probability": 0.6533203125}, {"start": 1330.4, "end": 1331.06, "word": " «W»", "probability": 0.8873697916666666}, {"start": 1331.06, "end": 1331.82, "word": " Amino", "probability": 0.841552734375}, {"start": 1331.82, "end": 1332.18, "word": " Acid", "probability": 0.97900390625}, {"start": 1332.18, "end": 1332.74, "word": " تاني", "probability": 0.8717447916666666}, {"start": 1332.74, "end": 1334.28, "word": " فاللي", "probability": 0.9065755208333334}, {"start": 1334.28, "end": 1334.7, "word": " بيصير", "probability": 0.835693359375}, {"start": 1334.7, "end": 1335.3, "word": " أنه", "probability": 0.75732421875}, {"start": 1335.3, "end": 1335.72, "word": " بدل", "probability": 0.96875}, {"start": 1335.72, "end": 1336.12, "word": " كده", "probability": 0.768310546875}, {"start": 1336.12, "end": 1336.56, "word": " بيجي", "probability": 0.9246826171875}, {"start": 1336.56, "end": 1337.06, "word": " كده", "probability": 0.9803059895833334}, {"start": 1337.06, "end": 1338.58, "word": " فبدي", "probability": 0.6343587239583334}, {"start": 1338.58, "end": 1339.02, "word": " أقول", "probability": 0.807861328125}, {"start": 1339.02, "end": 1339.48, "word": " في", "probability": 0.712890625}, {"start": 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"probability": 0.876953125}], "temperature": 1.0}, {"id": 51, "seek": 137690, "start": 1350.3, "end": 1376.9, "text": "فهي عبارة عن One letter amino acid code is used في هذه الناحية والـ Position اللي صارت في الـ mutation هم بيحكيوكوا معاها مثل هي بتكون في الغالب زي الموضوع مثلا الـ Sickle cell اللي في الـ Position 6 في الـ Valine صار بدل الـ", "tokens": [5172, 3224, 1829, 6225, 3555, 9640, 3660, 18871, 1485, 5063, 24674, 8258, 3089, 307, 1143, 8978, 29538, 2423, 8315, 5016, 10632, 16070, 39184, 29780, 13672, 1829, 20328, 9640, 2655, 8978, 2423, 39184, 27960, 8032, 2304, 4724, 1829, 5016, 4117, 1829, 2407, 4117, 14407, 20449, 995, 11296, 50113, 1211, 39896, 39894, 30544, 8978, 6024, 118, 6027, 3555, 30767, 1829, 9673, 2407, 11242, 45367, 50113, 15040, 2423, 39184, 43471, 306, 2815, 13672, 1829, 8978, 2423, 39184, 29780, 1386, 8978, 2423, 39184, 7188, 533, 20328, 9640, 47525, 1211, 2423, 39184], "avg_logprob": -0.29456676745956595, "compression_ratio": 1.6047619047619048, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1350.3, "end": 1350.7, "word": "فهي", "probability": 0.8429361979166666}, {"start": 1350.7, "end": 1351.24, "word": " عبارة", "probability": 0.9979248046875}, {"start": 1351.24, "end": 1351.76, "word": " عن", "probability": 0.99462890625}, {"start": 1351.76, "end": 1353.54, "word": " One", "probability": 0.1800537109375}, {"start": 1353.54, "end": 1354.02, "word": " letter", "probability": 0.231689453125}, {"start": 1354.02, "end": 1354.46, "word": " amino", "probability": 0.90771484375}, {"start": 1354.46, "end": 1354.84, "word": " acid", "probability": 0.94287109375}, {"start": 1354.84, "end": 1355.4, "word": " code", "probability": 0.90966796875}, {"start": 1355.4, "end": 1355.9, "word": " is", "probability": 0.0943603515625}, {"start": 1355.9, "end": 1356.38, "word": " used", "probability": 0.94384765625}, {"start": 1356.38, "end": 1356.6, "word": " في", "probability": 0.82080078125}, {"start": 1356.6, "end": 1356.8, "word": " هذه", "probability": 0.6279296875}, {"start": 1356.8, "end": 1357.36, "word": " الناحية", "probability": 0.8790283203125}, {"start": 1357.36, "end": 1358.54, "word": " والـ", "probability": 0.767333984375}, {"start": 1358.54, "end": 1359.64, "word": " Position", "probability": 0.50390625}, {"start": 1359.64, "end": 1360.58, "word": " اللي", "probability": 0.955810546875}, {"start": 1360.58, "end": 1361.1, "word": " صارت", "probability": 0.8489583333333334}, {"start": 1361.1, "end": 1361.26, "word": " في", "probability": 0.95849609375}, {"start": 1361.26, "end": 1361.4, "word": " الـ", "probability": 0.75439453125}, {"start": 1361.4, "end": 1362.0, "word": " mutation", "probability": 0.71142578125}, {"start": 1362.0, "end": 1362.82, "word": " هم", "probability": 0.69287109375}, {"start": 1362.82, "end": 1363.42, "word": " بيحكيوكوا", "probability": 0.796844482421875}, {"start": 1363.42, "end": 1363.98, "word": " معاها", "probability": 0.7991536458333334}, {"start": 1363.98, "end": 1364.74, "word": " مثل", "probability": 0.96435546875}, {"start": 1364.74, "end": 1365.0, "word": " هي", "probability": 0.197998046875}, {"start": 1365.0, "end": 1366.18, "word": " بتكون", "probability": 0.759521484375}, {"start": 1366.18, "end": 1366.5, "word": " في", "probability": 0.78564453125}, {"start": 1366.5, "end": 1367.12, "word": " الغالب", "probability": 0.9847412109375}, {"start": 1367.12, "end": 1368.26, "word": " زي", "probability": 0.918212890625}, {"start": 1368.26, "end": 1368.96, "word": " الموضوع", "probability": 0.86895751953125}, {"start": 1368.96, "end": 1370.2, "word": " مثلا", "probability": 0.708740234375}, {"start": 1370.2, "end": 1370.36, "word": " الـ", "probability": 0.77001953125}, {"start": 1370.36, "end": 1370.76, "word": " Sickle", "probability": 0.897216796875}, {"start": 1370.76, "end": 1371.12, "word": " cell", "probability": 0.505859375}, {"start": 1371.12, "end": 1371.98, "word": " اللي", "probability": 0.96484375}, {"start": 1371.98, 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أنا أشوف الرمز هذا أكون عندي تصور عن إيش بيته، إنه الآن بالأخير هنا في الـAsians، هنا في الـEuropeans الـ 31% من الـMutation من هذا النوع", "tokens": [6027, 39184, 1587, 1494, 533, 34051, 13672, 1829, 31439, 2423, 39184, 2012, 2982, 5097, 327, 13672, 1829, 20328, 9640, 8978, 3224, 1975, 46456, 15040, 5172, 12399, 3714, 33599, 1829, 22807, 23032, 3555, 3615, 995, 14111, 8032, 3215, 12610, 3660, 37893, 3714, 9566, 46152, 9307, 5296, 28543, 2288, 19446, 14739, 3224, 5296, 15042, 41850, 5551, 8592, 38688, 34892, 2304, 11622, 23758, 5551, 30544, 18871, 16254, 6055, 9381, 13063, 18871, 11933, 1829, 8592, 4724, 36081, 3224, 12399, 36145, 3224, 6024, 48506, 20666, 10721, 9778, 13546, 34105, 8978, 2423, 39184, 10884, 2567, 12399, 34105, 8978, 2423, 39184, 32293, 599, 2423, 39184, 10353, 4, 9154, 2423, 39184, 44, 11380, 9154, 23758, 28239, 45367], "avg_logprob": -0.23153408819978888, "compression_ratio": 1.591093117408907, "no_speech_prob": 2.1457672119140625e-06, "words": [{"start": 1378.31, 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2048.41, "word": " إيش", "probability": 0.7849934895833334}, {"start": 2048.41, "end": 2048.83, "word": " اسمه", "probability": 0.92529296875}, {"start": 2048.83, "end": 2049.13, "word": " Alpha", "probability": 0.8154296875}, {"start": 2049.13, "end": 2049.51, "word": "-1", "probability": 0.858642578125}, {"start": 2049.51, "end": 2050.51, "word": "-antitrypsin", "probability": 0.775146484375}, {"start": 2050.51, "end": 2051.69, "word": " عبارة", "probability": 0.9134521484375}, {"start": 2051.69, "end": 2051.93, "word": " عن", "probability": 0.998046875}, {"start": 2051.93, "end": 2052.61, "word": " إنزايم", "probability": 0.73138427734375}, {"start": 2052.61, "end": 2054.41, "word": " الـTrypsin", "probability": 0.70855712890625}, {"start": 2054.41, "end": 2054.89, "word": " اللي", "probability": 0.88134765625}, {"start": 2054.89, "end": 2055.95, "word": " هو", "probability": 0.96923828125}, {"start": 2055.95, "end": 2057.65, "word": " عبارة", "probability": 0.990478515625}, 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{"start": 2096.62, "end": 2097.24, "word": " عندنا", "probability": 0.551361083984375}, {"start": 2097.24, "end": 2098.24, "word": " إنزال", "probability": 0.6184895833333334}, {"start": 2098.24, "end": 2098.38, "word": " أن", "probability": 0.12548828125}, {"start": 2098.38, "end": 2098.68, "word": " ربنا", "probability": 0.9283854166666666}, {"start": 2098.68, "end": 2099.02, "word": " حطه", "probability": 0.9552408854166666}, {"start": 2099.02, "end": 2099.5, "word": " فينا", "probability": 0.9853515625}, {"start": 2099.5, "end": 2099.88, "word": " دا", "probability": 0.694091796875}, {"start": 2099.88, "end": 2100.48, "word": " قضية", "probability": 0.9869791666666666}, {"start": 2100.48, "end": 2100.9, "word": " الـ", "probability": 0.89892578125}, {"start": 2100.9, "end": 2101.22, "word": " Alpha", "probability": 0.6591796875}, {"start": 2101.22, "end": 2101.66, "word": "-1", "probability": 0.859375}, {"start": 2101.66, "end": 2102.66, "word": "-Antitrypsin", "probability": 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"probability": 0.8188720703125}, {"start": 2637.44, "end": 2638.14, "word": " يعني", "probability": 0.88330078125}, {"start": 2638.14, "end": 2638.78, "word": " على", "probability": 0.92529296875}, {"start": 2638.78, "end": 2639.22, "word": " الأقل", "probability": 0.7923177083333334}, {"start": 2639.22, "end": 2640.38, "word": " يعني", "probability": 0.7568359375}, {"start": 2640.38, "end": 2640.98, "word": " الـMajor", "probability": 0.89287109375}, {"start": 2640.98, "end": 2641.32, "word": " One", "probability": 0.5107421875}, {"start": 2641.32, "end": 2642.62, "word": " في", "probability": 0.8876953125}, {"start": 2642.62, "end": 2643.38, "word": " قضية", "probability": 0.9964192708333334}, {"start": 2643.38, "end": 2646.66, "word": " المسبب", "probability": 0.9469401041666666}, {"start": 2646.66, "end": 2647.06, "word": " لهذه", "probability": 0.943359375}, {"start": 2647.06, "end": 2647.72, "word": " الحالة", "probability": 0.9933268229166666}, {"start": 2647.72, "end": 2648.3, 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راح يصير في ارتفاع شديد وبالتالي يصير في عندنا accumulation لهذا يعني احنا حكينا عن الفنع الألليل بالـBq هو الـGlycine اللي دخل بالبرفيل", "tokens": [3224, 2407, 13672, 1829, 4724, 1829, 25957, 1211, 18863, 2288, 16758, 29538, 4032, 19528, 11703, 995, 7251, 30544, 8978, 3224, 2193, 1229, 1398, 3714, 9566, 1211, 37746, 32767, 35473, 16758, 12610, 1829, 11622, 2304, 20449, 9957, 3660, 2423, 33599, 1829, 13672, 1829, 12174, 36150, 2423, 39184, 16257, 1229, 1398, 23758, 8717, 31371, 7435, 3660, 16490, 1211, 1211, 2423, 39184, 16257, 1229, 1398, 12602, 39319, 7251, 9381, 13546, 8978, 1975, 43500, 5172, 45761, 13412, 16254, 3215, 46599, 6027, 2655, 6027, 1829, 7251, 9381, 13546, 8978, 43242, 8315, 35647, 46740, 15730, 37495, 22653, 1975, 5016, 8315, 11331, 4117, 1829, 8315, 18871, 27188, 1863, 3615, 16247, 1211, 20292, 1211, 20666, 39184, 33, 80, 31439, 2423, 39184, 38, 356, 66, 533, 13672, 1829, 11778, 9778, 1211, 20666, 26890, 5172, 26895], "avg_logprob": -0.2202263805340594, 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الـAmino-Lidulinic Acid Synthetic Defect ويصير هنا Glycine يعني الواحد إنه كمان يعرف", "tokens": [5172, 6027, 20292, 8032, 11536, 13672, 1829, 11331, 995, 4117, 9957, 3224, 13672, 1829, 39896, 12174, 11242, 10632, 10223, 12, 37, 911, 794, 1734, 7052, 4987, 804, 28877, 662, 4785, 29538, 4724, 43042, 3224, 9154, 9673, 8592, 995, 28820, 6225, 2288, 46958, 6225, 9381, 3555, 10632, 39182, 29739, 1211, 2407, 17082, 4032, 3224, 2655, 30544, 8717, 31371, 7435, 3660, 37893, 28820, 3660, 8978, 2423, 39184, 9171, 282, 533, 2423, 39184, 32, 2367, 78, 12, 43, 327, 17701, 299, 5097, 327, 318, 18656, 3532, 1346, 1836, 4032, 1829, 9381, 13546, 34105, 460, 356, 66, 533, 37495, 22653, 2423, 14407, 24401, 36145, 3224, 9122, 2304, 7649, 37495, 28480], "avg_logprob": -0.2824182259702237, "compression_ratio": 1.421487603305785, "no_speech_prob": 8.344650268554688e-07, "words": [{"start": 2685.74, "end": 2687.36, "word": "فاللي", "probability": 0.5390625}, {"start": 2687.36, "end": 2687.66, "word": " هون", 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" انه", "probability": 0.6112060546875}, {"start": 4467.04, "end": 4467.26, "word": " يكون", "probability": 0.98974609375}, {"start": 4467.26, "end": 4467.94, "word": " مستقل", "probability": 0.9609375}, {"start": 4467.94, "end": 4468.46, "word": " يكون", "probability": 0.72119140625}, {"start": 4468.46, "end": 4469.36, "word": " انه", "probability": 0.841552734375}, {"start": 4469.36, "end": 4469.96, "word": " هو", "probability": 0.8154296875}, {"start": 4469.96, "end": 4472.14, "word": " يعني", "probability": 0.92041015625}, {"start": 4472.14, "end": 4474.34, "word": " هو", "probability": 0.83837890625}, {"start": 4474.34, "end": 4475.12, "word": " مستقل", "probability": 0.9918212890625}, {"start": 4475.12, "end": 4475.52, "word": " وهو", "probability": 0.7119140625}, {"start": 4475.52, "end": 4476.1, "word": " يقدر", "probability": 0.9881184895833334}, {"start": 4476.1, "end": 4477.06, "word": " يعمل", "probability": 0.8148600260416666}, {"start": 4477.06, "end": 4478.62, "word": " يعيش", "probability": 0.8761393229166666}, {"start": 4478.62, "end": 4479.5, "word": " بحياته", "probability": 0.91650390625}, {"start": 4479.5, "end": 4480.64, "word": " أنا", "probability": 0.6982421875}, {"start": 4480.64, "end": 4481.02, "word": " مضطر", "probability": 0.962158203125}, {"start": 4481.02, "end": 4481.42, "word": " هسة", "probability": 0.5608723958333334}, {"start": 4481.42, "end": 4482.04, "word": " أترك", "probability": 0.8972981770833334}, {"start": 4482.04, "end": 4483.46, "word": " ماشي", "probability": 0.8689778645833334}, {"start": 4483.46, "end": 4484.04, "word": " و", "probability": 0.97607421875}, {"start": 4484.04, "end": 4484.8, "word": " بنكمل", "probability": 0.8006184895833334}, {"start": 4484.8, "end": 4485.1, "word": " يوم", "probability": 0.9677734375}, {"start": 4485.1, "end": 4486.3, "word": " الأربعاء", "probability": 0.7408447265625}, {"start": 4486.3, "end": 4486.68, "word": " عشان", "probability": 0.6500040690104166}, {"start": 4486.68, "end": 4486.92, "word": " أقول", "probability": 0.5888671875}, {"start": 4486.92, "end": 4487.82, "word": " للعالمين", "probability": 0.725067138671875}, {"start": 4487.82, "end": 4488.56, "word": " يعطيك", "probability": 0.920166015625}, {"start": 4488.56, "end": 4488.72, "word": " ألف", "probability": 0.8310546875}, {"start": 4488.72, "end": 4488.9, "word": " عفو", "probability": 0.6356608072916666}, {"start": 4488.9, "end": 4489.08, "word": " يا", "probability": 0.85400390625}, {"start": 4489.08, "end": 4489.6, "word": " دكتور", "probability": 0.9759521484375}, {"start": 4489.6, "end": 4490.08, "word": " أهلا", "probability": 0.91748046875}, {"start": 4490.08, "end": 4490.3, "word": " و", "probability": 0.85791015625}, {"start": 4490.3, "end": 4490.48, "word": " سهلا", "probability": 0.92138671875}], "temperature": 1.0}, {"id": 163, "seek": 450404, "start": 4492.66, "end": 4504.04, "text": "نعم لأ هو خارج المحاضرة خلاص مش مشكلة خير الله يعطيك ألف عفو يا دكتور الله يحييكم أهلا وسهلا نشوفكم على خير ان شاء الله", "tokens": [1863, 25957, 5296, 10721, 31439, 16490, 9640, 7435, 9673, 5016, 46958, 25720, 16490, 1211, 33546, 37893, 37893, 28820, 3660, 16490, 13546, 21984, 7251, 3615, 9566, 1829, 4117, 5551, 46538, 6225, 5172, 2407, 35186, 11778, 4117, 2655, 13063, 21984, 7251, 5016, 1829, 1829, 24793, 5551, 3224, 15040, 46952, 3224, 15040, 8717, 8592, 38688, 24793, 15844, 16490, 13546, 16472, 13412, 16606, 21984], "avg_logprob": -0.1781506079142211, "compression_ratio": 1.633587786259542, "no_speech_prob": 4.655122756958008e-05, "words": [{"start": 4492.659999999999, "end": 4493.299999999999, "word": "نعم", "probability": 0.842529296875}, {"start": 4493.299999999999, "end": 4493.94, "word": " لأ", "probability": 0.578857421875}, {"start": 4493.94, "end": 4494.14, "word": " هو", "probability": 0.90966796875}, {"start": 4494.14, "end": 4494.6, "word": " خارج", "probability": 0.9952799479166666}, {"start": 4494.6, "end": 4495.12, "word": " المحاضرة", "probability": 0.9832763671875}, {"start": 4495.12, "end": 4495.38, "word": " خلاص", "probability": 0.9609375}, {"start": 4495.38, "end": 4495.52, "word": " مش", "probability": 0.73583984375}, {"start": 4495.52, "end": 4495.8, "word": " مشكلة", "probability": 0.98095703125}, {"start": 4495.8, "end": 4496.18, "word": " خير", "probability": 0.661376953125}, {"start": 4496.18, "end": 4496.62, "word": " الله", "probability": 0.63623046875}, {"start": 4496.62, "end": 4499.04, "word": " يعطيك", "probability": 0.7556640625}, {"start": 4499.04, "end": 4499.24, "word": " ألف", "probability": 0.80615234375}, {"start": 4499.24, "end": 4499.44, "word": " عفو", "probability": 0.645751953125}, {"start": 4499.44, "end": 4499.56, "word": " يا", "probability": 0.919921875}, {"start": 4499.56, "end": 4499.84, "word": " دكتور", "probability": 0.972412109375}, {"start": 4499.84, "end": 4500.0, "word": " الله", "probability": 0.7412109375}, {"start": 4500.0, "end": 4500.7, "word": " يحييكم", "probability": 0.85}, {"start": 4500.7, "end": 4501.02, "word": " أهلا", "probability": 0.9762369791666666}, {"start": 4501.02, "end": 4501.52, "word": " وسهلا", "probability": 0.9539388020833334}, {"start": 4501.52, "end": 4502.28, "word": " نشوفكم", "probability": 0.9345703125}, {"start": 4502.28, "end": 4502.5, "word": " على", "probability": 0.96923828125}, {"start": 4502.5, "end": 4503.02, "word": " خير", "probability": 0.996826171875}, {"start": 4503.02, "end": 4503.6, "word": " ان", "probability": 0.400146484375}, {"start": 4503.6, "end": 4503.84, "word": " شاء", "probability": 0.98193359375}, {"start": 4503.84, "end": 4504.04, "word": " الله", "probability": 0.96337890625}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 4508.8508125, "duration_after_vad": 4423.900624999998}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/uzpVhimo_X4.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/uzpVhimo_X4.srt
new file mode 100644
index 0000000000000000000000000000000000000000..65b839f635c3432d402eb1ee40e34ad56b6cbbcd
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/uzpVhimo_X4.srt
@@ -0,0 +1,2467 @@
+1
+00:00:00,490 --> 00:00:06,230
+يعني إحنا الآن مطلوب من الطلاب أنهم يحلوا الأسئلة
+
+2
+00:00:06,230 --> 00:00:11,510
+اللي في المراجع الموجودة، الـUSMLE وغيرها
+
+3
+00:00:11,510 --> 00:00:23,620
+وبالتالي يعني يكون إذا في شيء صعب، راح نقشه، وراح نبدأ
+
+4
+00:00:23,620 --> 00:00:31,920
+ناخذ يعني سؤال، فيه أحدكم بعتلي إياه، إنه مش فاهم أو
+
+5
+00:00:31,920 --> 00:00:38,340
+كان فيه صعوبة، فبحاول
+
+6
+00:00:38,340 --> 00:00:42,920
+أن الأشياء اللي يعني شعرت أنه يمكن ما شددت عليها
+
+7
+00:00:42,920 --> 00:00:49,930
+واضحتها بالنسبة للمحاضرة، نتكلم عنها، ونشوف كيف
+
+8
+00:00:49,930 --> 00:00:59,090
+الموضوع، وكيف بيجي يعني النقطة الأولى فيه، اللي هو
+
+9
+00:00:59,090 --> 00:01:02,390
+موضوع الـ Linkage Equilibrium والـ Linkage
+
+10
+00:01:02,390 --> 00:01:09,510
+Disequilibrium، توزع الإتزان وعدم الإتزان في
+
+11
+00:01:09,510 --> 00:01:20,540
+الترابط. إحنا هنا السؤال بيقول إنه درجة قرب موقعين
+
+12
+00:01:20,540 --> 00:01:28,320
+two loci for two genes مثلًا، أنا المثال اللي
+
+13
+00:01:28,320 --> 00:01:35,600
+دائمًا بضربه، اللي هو الـ HLA-A بعيد عن الـ B، بس
+
+14
+00:01:35,600 --> 00:01:42,800
+الـ HLA-C قريب جدًا من الـ B. حكيت هذا الكلام، دخل حتى
+
+15
+00:01:42,800 --> 00:01:48,600
+سريريًا، إنه إحنا لما نعمل HLA-Typing، لما نقرر
+
+16
+00:01:48,600 --> 00:01:55,640
+عمليات نقل الأعضاء، وما نقل الأعضاء وكذا، بنفحص على
+
+17
+00:01:55,640 --> 00:02:01,520
+الـ A وعلى الـ B والـ C لأنه مربوط مع الـ B، حتى ما
+
+18
+00:02:01,520 --> 00:02:07,040
+بنحتاج نفحص عليه. فالفكرة تبعتها، اللي هي إنه بنقول
+
+19
+00:02:07,040 --> 00:02:14,000
+فيه Linked disequilibrium بسبب الترابط، لأنه قريبات
+
+20
+00:02:14,000 --> 00:02:20,940
+على بعض. إذا كان الـ B شكل معين، الـ C بكون شكل محدد
+
+21
+00:02:20,940 --> 00:02:26,200
+كمان، يعني في ارتباط زيادة. فالـ
+
+22
+00:02:26,830 --> 00:02:30,510
+المثال اللي حاطينه في الـ Figure اللي راح أفرجيكم إياه
+
+23
+00:02:30,510 --> 00:02:36,470
+وإذا راح أحط Share Screen دقيقة
+
+24
+00:02:36,470 --> 00:02:46,050
+إذا راح أحط Share Screen، اللي هو هذا المثال، خلينا
+
+25
+00:02:46,050 --> 00:02:51,730
+هيك نقرأ الأرقام هذه في
+
+26
+00:02:51,730 --> 00:02:57,370
+الحالة الأولى، نفترض افتراضًا، إنه أنا عندي Two Loci
+
+27
+00:02:57,370 --> 00:03:00,590
+و
+
+28
+00:03:00,590 --> 00:03:08,190
+Two Alleles، يعني في كل الـ Gene في كل محل فيه
+
+29
+00:03:08,190 --> 00:03:15,110
+نسختين أو نوعين مختلفين من الـ… يعني مثلًا أنا
+
+30
+00:03:15,110 --> 00:03:20,590
+بتكلم عن الـ ABO System والـ Rh System، هذول Two
+
+31
+00:03:20,590 --> 00:03:27,980
+Loci، واحد في الـ ABO بيكون يا A يا B يا O، والـ
+
+32
+00:03:27,980 --> 00:03:32,500
+Rh يا بكون Positive أو Negative، الـ Capital D
+
+33
+00:03:32,500 --> 00:03:36,540
+أو الـ Small d.  في بعض، فإذا أنا
+
+34
+00:03:36,540 --> 00:03:44,160
+جيت مثلًا في الـ Locus A، كان عندي مثلًا نفترض
+
+35
+00:03:44,160 --> 00:03:47,120
+الـ A الـ Capital والـ A الـ Small، أنا عارف
+
+36
+00:03:47,120 --> 00:03:56,500
+إنهم 0.5 و 0.5. هدول بيعطونا الـ الـ الـ الـ
+
+37
+00:03:56,500 --> 00:04:06,080
+frequencies تبع الأليل اللي أنا عارفه، ماشي؟ وبعدين
+
+38
+00:04:06,080 --> 00:04:15,160
+الـ locus الثاني،  الـ capital S والـ small s
+
+39
+00:04:15,160 --> 00:04:22,940
+هو 0.1 و 0.9. يعني هنا السائد 10% والمتنحي
+
+40
+00:04:22,940 --> 00:04:27,380
+90%. فإذا
+
+41
+00:04:27,380 --> 00:04:34,960
+بلاقي النسب،  للإثنين هذول، لما آجي أدرس نفس
+
+42
+00:04:34,960 --> 00:04:40,320
+الإنسان للـ two loci، وأشوف شو الأليل اللي موجود
+
+43
+00:04:40,320 --> 00:04:44,260
+عنده في كل الأماكن، اللي هم المكانين هنا اللي أنا
+
+44
+00:04:44,260 --> 00:04:49,420
+بفحص عليهم، الـ Two copies، وبلاقي النسب بهذه
+
+45
+00:04:49,420 --> 00:04:57,180
+الطريقة، معناته إنه هذول الـ Two loci ما لهم أي
+
+46
+00:04:57,180 --> 00:05:04,980
+ترابط ما في بينهم،  لأن نسبهم، نسب يعني هي
+
+47
+00:05:04,980 --> 00:05:10,860
+المتوقعة من الـ General population، من المعرفة
+
+48
+00:05:10,860 --> 00:05:16,060
+السابقة عندي، بالنسبة للنسبة للأليلات هذول
+
+49
+00:05:16,060 --> 00:05:22,100
+و distribution تبعاتهم في الـ population. لو أنا مثلًا
+
+50
+00:05:22,100 --> 00:05:33,640
+لقيت حالة الـ okay، هذا 0.1% الـ locus 2 الـ
+
+51
+00:05:33,640 --> 00:05:40,870
+S والـ locus 2 الـ small s، 0.9. هذه 10% وهذه
+
+52
+00:05:40,870 --> 00:05:48,050
+90%. فأنا عارف إنه الأصل هذول نص بنص، آجي ألاقي إن
+
+53
+00:05:48,050 --> 00:05:51,910
+اللي عندهم Capital A و Capital S، ما فيش ولا حد بهذا
+
+54
+00:05:51,910 --> 00:05:59,010
+الشكل، يعني كل اللي عندهم Capital S طلع عندهم Small
+
+55
+00:05:59,010 --> 00:06:06,110
+a، فإذن في ارتباط في الحالة هذه، لأن هذه النسب مش
+
+56
+00:06:06,110 --> 00:06:12,950
+نتيجة ضرب المعروف والمعلوم من نسب الأليلات اللي
+
+57
+00:06:12,950 --> 00:06:19,150
+موجودة في كل شيء. فلما أشوف أنا بهذا الشكل، وهنا
+
+58
+00:06:19,150 --> 00:06:24,970
+يعني المفروض هي 0.1 وهي 0.5، 0.5 يعني نصهم هيك و
+
+59
+00:06:24,970 --> 00:06:32,210
+نصهم هيك، هيك الأصل، وهنا الأصل، إذا 90% لازم يكون
+
+60
+00:06:32,210 --> 00:06:36,530
+نصهم هيك ونصهم هيك. لما أشوف الاختلالات بهذا الشكل،
+
+61
+00:06:36,530 --> 00:06:43,340
+معناته أنه فيه ارتباط، وبالتالي ما فيش توازن في النسب
+
+62
+00:06:43,340 --> 00:06:48,000
+تبعاتهم، نسميه linkage disequilibrium، وهذه الظاهرة
+
+63
+00:06:48,000 --> 00:06:53,620
+ممكن تكون يعني مش قوية تمامًا بهذا الشكل، فيه ممكن
+
+64
+00:06:53,620 --> 00:06:57,620
+تكون شكل جزئي، فبالتالي فيه بيصير linkage
+
+65
+00:06:57,620 --> 00:07:02,820
+disequilibrium partial، بهذا الشكل. يعني أرجو أنها
+
+66
+00:07:02,820 --> 00:07:07,190
+تكون واضحة، وهذه النقطة الأولى، بحب أؤكد عليها من
+
+67
+00:07:07,190 --> 00:07:16,410
+مراجعة الـ Quiz تبع المرة اللي كانت فيه أسئلة؟ -
+
+68
+00:07:16,410 --> 00:07:18,950
+أعطيك العافية يا أختي - الله يعافيك يا أستاذ
+
+69
+00:07:18,950 --> 00:07:23,330
+الكريم، تفضل - الأخت دلوقتي، أسئلة أنت حكيتها، ولا فيها قبل -
+
+70
+00:07:23,330 --> 00:07:26,810
+أنا بقى اشتغلت في سؤال على السؤال
+
+71
+00:07:26,810 --> 00:07:33,630
+اللي لسه شرحته - هلأ تمام بس - نعم - هلأ تمام،
+
+72
+00:07:33,630 --> 00:07:38,630
+بس في حاجة ثانية، اللي هي بس إذا حد عنده عن هاي
+
+73
+00:07:38,630 --> 00:07:42,890
+وبعدين فيه نقطة ثانية، بس هيك بدي أرجعها مرة ثانية
+
+74
+00:07:42,890 --> 00:07:47,390
+وبعدين فيه سؤال اللي واحد بعتني إياه على
+
+75
+00:07:47,390 --> 00:07:54,610
+الـ WhatsApp، بدخل عليه وبنشوفه، وبعدين أي حد عنده أي
+
+76
+00:07:54,610 --> 00:08:00,270
+سؤال بنرجع له، بنفرجيك من وين سؤاله، وبنتكلم عنه، فبس
+
+77
+00:08:00,270 --> 00:08:01,770
+في حد عنده سؤال؟ هذا
+
+78
+00:08:09,980 --> 00:08:19,280
+طيب النقطة الثانية، حابب إنها تكون واضحة عندكم، اللي
+
+79
+00:08:19,280 --> 00:08:24,940
+هي الفرق بين الـ Association والـ Linkage، يعني
+
+80
+00:08:24,940 --> 00:08:33,040
+المواضيع في هذا الجزء، يعني هو فصل بعنوان "identify
+
+81
+00:08:33,040 --> 00:08:36,560
+the genetic basis of human disease"، يعني كيف أنا
+
+82
+00:08:36,560 --> 00:08:47,300
+بدي أدخل معرفتي بالـ… بالـ Genetics، واستخدام الـ PCR
+
+83
+00:08:47,300 --> 00:08:53,480
+والتركيب الدقيق للجين في المرض، أو على الأمراض
+
+84
+00:08:53,480 --> 00:08:57,700
+فالنقطة
+
+85
+00:08:57,700 --> 00:09:02,520
+المهمة، يعني الواحد يكون فاهمها، اللي هي إنه أنا
+
+86
+00:09:02,520 --> 00:09:10,530
+مرات نتكلم مثلًا على إن الـ HLA-B27 is linked to
+
+87
+00:09:10,530 --> 00:09:16,550
+ankylosing spondylitis، أو إذا فيه اندياسي بنسميه
+
+88
+00:09:16,550 --> 00:09:20,850
+association، يعني فيه كلمة مرات بيستخدموا كلمة
+
+89
+00:09:20,850 --> 00:09:26,170
+linkage ومرات بيستخدموا association. فالـ linkage
+
+90
+00:09:26,170 --> 00:09:32,050
+وهي يعني زي ما أنتم شايفين هنا، عبارة عن مجموعة
+
+91
+00:09:32,050 --> 00:09:34,470
+نقاط، ماشي؟
+
+92
+00:09:36,840 --> 00:09:43,520
+بتفرق بين أمتى أستخدم كلمة أنا في ارتباط، وفي
+
+93
+00:09:43,520 --> 00:09:49,120
+علاقة، يعني هم الكلمات متشابهة، بس بتكلم عن نقاط
+
+94
+00:09:49,120 --> 00:09:54,060
+شويه مختلفة. فلما نقول linkage، هو it follows the
+
+95
+00:09:54,060 --> 00:09:58,780
+inheritance of the disease trait and regions of
+
+96
+00:09:58,780 --> 00:10:03,120
+the genome from individual to individual in family
+
+97
+00:10:03,120 --> 00:10:13,090
+by degrees، يعني لما أنا أجيب عائلة فيها مثلًا أشخاص
+
+98
+00:10:13,090 --> 00:10:18,530
+مصابين، وفيها أشخاص طبيعيين، هاي اسمها linkage،
+
+99
+00:10:18,530 --> 00:10:23,950
+ماشي؟ الـ Association اللي
+
+100
+00:10:23,950 --> 00:10:28,890
+هي لما نكون في test للـ altered frequency of
+
+101
+00:10:28,890 --> 00:10:32,470
+particular alleles or haplotypes in affected
+
+102
+00:10:32,470 --> 00:10:37,210
+individuals compared with controls in a population
+
+103
+00:10:37,210 --> 00:10:49,630
+يعني هنا الـ… الـ… يعني أنا بسوي شيء مشابه، هو
+
+104
+00:10:49,630 --> 00:10:56,020
+أنا بجيب ناس عندهم المرض، وفي ناس سليمين، وبشوف
+
+105
+00:10:56,020 --> 00:11:06,340
+الفرق بين نسب ظهور الـ certain alleles أو
+
+106
+00:11:06,340 --> 00:11:09,820
+الشيء اللي أنا بدرس عليه، أو الـ haplotype، بطريقة
+
+107
+00:11:09,820 --> 00:11:15,780
+معينة بين مجموعة مصابة وبين الـ General Population
+
+108
+00:11:15,780 --> 00:11:19,800
+فهنا بنقولها Association،  فديّك بسميها Linkage
+
+109
+00:11:23,250 --> 00:11:27,770
+الـ Association يبحث عن مقاطع الجينوم اللي تتعامل مع
+
+110
+00:11:27,770 --> 00:11:30,270
+الـ Disease alleles، ويستخدم الـ Polymorphic
+
+111
+00:11:30,270 --> 00:11:36,270
+Variants فقط كطريقة لتواصل أي مقاطع تتعامل معها من
+
+112
+00:11:36,270 --> 00:11:43,830
+أي والد. وهي برضه، يعني، الـ Association يستخدم الـ
+
+113
+00:11:43,830 --> 00:11:46,610
+hundreds، الـ Association يستخدم الـ hundreds لـ
+
+114
+00:11:46,610 --> 00:11:53,730
+thousands of polymorphic markers عبر الجينوم التي
+
+115
+00:11:53,730 --> 00:12:00,190
+ليست مصممة لإيجاد الـ variant المسؤول عنها، أو تسبب
+
+116
+00:12:00,190 --> 00:12:04,930
+في المرض، يمكن أن تمثل أين يمكن أن تجد الـ
+
+117
+00:12:04,930 --> 00:12:12,030
+variant، في عامة واحد أو عامة ميغابايت. يعني لما
+
+118
+00:12:12,030 --> 00:12:18,840
+أقول أنا فيه Linkage، أنا حتى يعني بحاول إن حد
+
+119
+00:12:18,840 --> 00:12:23,500
+يحدد الـ specific variant. إحنا حتى بيكون الـ
+
+120
+00:12:23,500 --> 00:12:34,940
+Linkage مع اللي هو قطعة كبيرة. الـ Linkage relies on
+
+121
+00:12:34,940 --> 00:12:38,240
+recombination
+
+122
+00:12:38,240 --> 00:12:43,180
+events occurring in families during only a few
+
+123
+00:12:43,180 --> 00:12:45,970
+generations، to allow "مقارنة جينية بين جينوم المرض، ومقارنة"
+
+124
+00:12:45,970 --> 00:12:49,690
+الجينية بين جينوم المرضى، ومقارنة المرضى
+
+125
+00:12:49,690 --> 00:12:50,910
+ومقارنة المرضى، ومقارنة المرضى، ومقارنة
+
+126
+00:12:50,910 --> 00:12:51,710
+المرضى، ومقارنة المرضى، ومقارنة المرضى، ومقارنة
+
+127
+00:12:51,710 --> 00:12:55,470
+المرضى، ومقارنة المرضى، ومقارنة المرضى، ومقارنة المرضى
+
+128
+00:12:55,470 --> 00:12:55,850
+ومقارنة المرضى، ومقارنة المرضى، ومقارنة المرضى، ومقارنة
+
+129
+00:12:55,850 --> 00:12:59,450
+المرضى، ومقارنة المرضى، ومقارنة المرضى، ومقارنة
+
+130
+00:12:59,450 --> 00:13:09,240
+المرضى، ومقارنة… ما بكون ما هو اسمه؟ ما بيكون يعني ربطة
+
+131
+00:13:09,240 --> 00:13:14,720
+الـ Disease بالمرض مع الـ Gene هذا. يعني إحنا لما
+
+132
+00:13:14,720 --> 00:13:23,300
+درسنا مثلًا البيئة الـ S-Hemoglobin variation، مقابل
+
+133
+00:13:23,300 --> 00:13:28,780
+الـ Sickle Cell Disease، علينا نفهم ليش هذا الـ
+
+134
+00:13:28,780 --> 00:13:34,180
+Gene بدأ. أما لما أنا أعمل linkage، يمكن اللي أنا
+
+135
+00:13:34,180 --> 00:13:41,300
+بربطه مع المرض هو مكان أنا يعني بيحتوي أو قريب من
+
+136
+00:13:41,300 --> 00:13:45,540
+الـ Gene تبع الـ Disease، بس أنا ما بكون بعرف ليش أو
+
+137
+00:13:45,540 --> 00:13:50,060
+كيف هذا بيؤدي للمرض. Requires sampling of families
+
+138
+00:13:50,060 --> 00:13:53,540
+not just people affected with the disease. I
+
+139
+00:13:53,540 --> 00:13:58,930
+في الـ Linkage، loses power when disease has complex
+
+140
+00:13:58,930 --> 00:14:01,870
+inheritance and substantial lack of penetrance
+
+141
+00:14:01,870 --> 00:14:09,410
+more often، أو
+
+142
+00:14:09,410 --> 00:14:14,510
+most often used to map disease-causing mutations
+
+143
+00:14:14,510 --> 00:14:17,930
+with strong enough effect to cause a Mendelian
+
+144
+00:14:17,930 --> 00:14:22,610
+inheritance pattern. يعني الفكرة اللي بدي أوصلها
+
+145
+00:14:22,610 --> 00:14:31,500
+إنه عملية الـ linkage هي عملية يعني إن أنا أقول
+
+146
+00:14:31,500 --> 00:14:38,640
+نتيجة دراسة عائلة فيها ناس مصابين وناس مش مصابين،
+
+147
+00:14:38,640 --> 00:14:46,540
+إن أنا قدرت أحدد علاقة مكانية في الـ Genome، في
+
+148
+00:14:46,540 --> 00:14:54,170
+ارتباط بينه وبين الـ… بينه وبين الـ Disease، وبكون
+
+149
+00:14:54,170 --> 00:15:00,850
+أنا اللي بستخدمه كـ Marker لمعرفة هذا الارتباط، ليس
+
+150
+00:15:00,850 --> 00:15:06,790
+بالضرورة مفسر أو شارح أو محدد لآلية تسبب المرض
+
+151
+00:15:06,790 --> 00:15:11,900
+يعني ممكن اللي أنا، المنطقة اللي أربطها مع المرض، هي
+
+152
+00:15:11,900 --> 00:15:20,780
+منطقة يعني مش… يعني ما فيها شيء أنا بقدره كـ Disease
+
+153
+00:15:20,780 --> 00:15:27,000
+زي الـ S-Hemoglobin و Sickle Cell Disease، أقول هذا
+
+154
+00:15:27,000 --> 00:15:30,800
+هيك يسوي المرض هيك. فهذه العلاقة اللي هي في قضية
+
+155
+00:15:30,800 --> 00:15:34,550
+الـ Linkage. أما لما نحكي Association، الـ
+
+156
+00:15:34,550 --> 00:15:42,390
+Association هي دراسات بتكون على مستوى… بتكون على مستوى
+
+157
+00:15:42,390 --> 00:15:45,770
+يعني مختلف، اللي هو الـ frequency of the allele
+
+158
+00:15:45,770 --> 00:15:52,210
+between group of patients و group of controls في
+
+159
+00:15:52,210 --> 00:16:00,050
+الـ population. فهي يعني اللي كنت حابب، نقطة ثانية من
+
+160
+00:16:00,050 --> 00:16:00,570
+حقها.
+
+161
+00:16:04,020 --> 00:16:13,100
+النقطة الأخيرة، بدي أفرجيكم إياها ثواني عشان نسوي
+
+162
+00:16:13,100 --> 00:16:20,680
+Share Screen، اللي هو سؤال بعضكم طرحه، فيه شيء مش
+
+163
+00:16:20,680 --> 00:16:28,040
+فاهمه، مش فاهمه، اللي هو خلينا ننزل في السؤال لحد
+
+164
+00:16:28,040 --> 00:16:30,800
+ما نشوفه، أظن بيجي بعدين
+
+165
+00:16:49,900 --> 00:16:54,740
+سؤال؟ كريم، عندك سؤال؟ حبيب، ما ألاقي السؤال، هلأ
+
+166
+00:16:54,740 --> 00:17:00,920
+أنا
+
+167
+00:17:00,920 --> 00:17:08,260
+شرح، مش سؤال، هو يعني إيه؟ نعم، آه تفضل، احكي. لأ،
+
+168
+00:17:08,260 --> 00:17:13,410
+في مواضيع من الـ First Aid بس ممكن تشرحها، تريد
+
+169
+00:17:13,410 --> 00:17:22,490
+تشرحها يعني؟ ماشي، طيب، بقدر تعمل Share Screen؟
+
+170
+00:17:22,490 --> 00:17:28,690
+بقدر أبعث لك صورة بس؟ نعم، أبعث الصورة في الـ chat
+
+171
+00:17:28,690 --> 00:17:36,350
+وتنزلها من هناك؟ إذا الـ admin بقدر يخليك تقدر تسوي
+
+172
+00:17:36,350 --> 00:17:42,800
+Share Screen مباشرة. هذول شفت الصور تبعت لما
+
+173
+00:17:42,800 --> 00:17:50,060
+الواحد يبعثها، يبعثلي إياها، وبعدين أنا أبعثه هيك، فبشوف
+
+174
+00:17:50,060 --> 00:18:00,740
+إنه ما بيطلع كويس، يعني مش كويس. طيب،
+
+175
+00:18:00,740 --> 00:18:08,090
+خلينا نراجع هذا السؤال، وبعدين من برضه الـ USMLE أو
+
+176
+00:18:08,090 --> 00:18:11,910
+أو Kaplan أو Genetics وكذا، من هنا الـ References،
+
+17
+
+223
+00:22:46,450 --> 00:22:48,190
+ماشي؟
+
+224
+00:22:49,720 --> 00:22:55,580
+فإذا أخذنا أي عائلة من هدول العائلات من الجدود كل
+
+225
+00:22:55,580 --> 00:23:05,440
+جد من الجدين في العائلتين أكيد carrier لأنه وخلف إذا
+
+226
+00:23:05,440 --> 00:23:10,880
+اتفقنا إنه فعلاً هو أبو الطفل هذا اللي ولد سواء
+
+227
+00:23:10,880 --> 00:23:18,580
+الأب أو الأم في الجيل الثاني ماشي، إذا الأب الجد هي
+
+228
+00:23:18,580 --> 00:23:22,540
+الجدود الأربعة لازم يكونوا carrier وهذا أنا أؤكد
+
+229
+00:23:22,540 --> 00:23:31,420
+متأكد منه، الأب وأخت الزوجة أكيد مصابين لأن عندهم
+
+230
+00:23:31,420 --> 00:23:38,380
+homozygous recessive، الـ small، فهذه أنا متأكد منهم
+
+231
+00:23:38,380 --> 00:23:45,880
+ماشي، بالنسبة ل... بما أنه أنا ما فحصت الأم للـ
+
+232
+00:23:45,880 --> 00:23:54,840
+carrier state، ماشي، بدي أعطي تقدير لقداش احتمالية
+
+233
+00:23:54,840 --> 00:24:04,020
+الجنين هذا يطلع positive، نسبة لقداش الأم، شو اسمه؟
+
+234
+00:24:04,020 --> 00:24:07,860
+احتمالية إنها تكون carrier وقداش نسبة إنها تعطي
+
+235
+00:24:07,860 --> 00:24:16,370
+الجيل تبع الإصابة، الأب أكيد راح يعطي 100% الـجين
+
+236
+00:24:16,370 --> 00:24:21,210
+تبع الإصابة لأن هو 100% مصاب، وبالتالي فإذا هو راح
+
+237
+00:24:21,210 --> 00:24:28,970
+يعطي 100%، بالنسبة للأم في الحالة هذه بدنا نطبق ما
+
+238
+00:24:28,970 --> 00:24:32,470
+يسمى الـ Conditional Probability، Conditional
+
+239
+00:24:32,470 --> 00:24:37,530
+Probability، يعني الاحتماليات المشروطة، وفي الحالة
+
+240
+00:24:37,530 --> 00:24:47,980
+هذه بنشوفها كالتالي، بالنسبة للـ يعني شو اللي
+
+241
+00:24:47,980 --> 00:24:52,260
+أثر على الـ conditional probability غير إن الأشياء
+
+242
+00:24:52,260 --> 00:24:57,940
+احنا بنعرفها، احنا بنعرف لما اثنين carriers
+
+243
+00:24:57,940 --> 00:25:03,880
+يتزاوجوا لـ autosomal recessive، الاحتمالات واحد
+
+244
+00:25:03,880 --> 00:25:09,120
+واثنين وواحد من أربعة، يعني هم أربع أرباع عادة
+
+245
+00:25:11,130 --> 00:25:16,050
+Capital A Capital A, Capital A Small a, Capital A
+
+246
+00:25:16,050 --> 00:25:20,230
+Small a, Small a, Small a، مثلًا، أنا عندي أربعة عدد
+
+247
+00:25:20,230 --> 00:25:23,610
+فلما
+
+248
+00:25:23,610 --> 00:25:28,850
+نكون heterozygous وcarrier
+
+249
+00:25:28,850 --> 00:25:36,970
+احتماليات منفصلة عن ما يمكن نشوفه، يعني أنا مثلًا
+
+250
+00:25:37,260 --> 00:25:41,200
+لما عائلة يتزوجوا ويقول احتمال نص يجيبوا ولد
+
+251
+00:25:41,200 --> 00:25:47,340
+احتمال نص يجيبوا بنت، ممكن ست مرات يطلع كله بنات
+
+252
+00:25:47,340 --> 00:25:52,220
+كله بنات، كله بنات، كله بنات، اللي بعده فيه memory
+
+253
+00:25:52,220 --> 00:25:57,180
+loss، يعني ما بتذكر النظام أنه الله أنا جيبت ست
+
+254
+00:25:57,180 --> 00:26:01,140
+بنات، ست بنات من قبل، لازم أجيب هسا ولد، مافي عندنا
+
+255
+00:26:01,140 --> 00:26:06,060
+إيش زيه، يظل الاحتمالية نص بنص يطلع ولد وبنت عادي
+
+256
+00:26:06,060 --> 00:26:12,130
+منفصلة، فهذه ظاهرة بتحدث صحيح بس في مرات إذا أنا
+
+257
+00:26:12,130 --> 00:26:13,190
+بعرف شو
+
+258
+00:26:13,190 --> 00:26:29,470
+الـ(incomplete sentence/unintelligible)
+
+259
+00:26:34,620 --> 00:26:38,120
+فإذا عندها small a وsmall a، أنا هايم أتأكد منها
+
+260
+00:26:38,120 --> 00:26:45,720
+الآن، الأخت اللي هي أم الجنين اللي عليه السؤال
+
+261
+00:26:45,720 --> 00:26:48,900
+وخالته
+
+262
+00:26:48,900 --> 00:26:59,060
+خال الجنين هذا، يعني أخو الأم، هنا ماشي، عليهم علامة
+
+263
+00:26:59,060 --> 00:27:07,070
+استفهام، لأنه احنا يعني مش عارفين، هي أصل النسب ربع
+
+264
+00:27:07,070 --> 00:27:13,430
+مُصاب، نصف carrier، وربع healthy، completely healthy
+
+265
+00:27:13,430 --> 00:27:20,350
+فالفكرة في كلمة Conditional Probability، إن أنا بما
+
+266
+00:27:20,350 --> 00:27:26,350
+إني عرفت إن هذا الإنسان مش مصاب، إذا مستحيل يكون
+
+267
+00:27:26,350 --> 00:27:30,710
+small a small a، فبتصير عندي النسب مش من أربعة
+
+268
+00:27:30,710 --> 00:27:36,460
+بيصير عندي النسب من ثلاثة، فبتصير ثلث مصابة تمامًا
+
+269
+00:27:36,460 --> 00:27:43,960
+وثلثين ماشية بيكونوا carrier، هيك النسب حسب
+
+270
+00:27:43,960 --> 00:27:50,440
+الاحتمالات، لأنه هنا وهنا أكيد carrier وهي مصابة
+
+271
+00:27:50,440 --> 00:27:54,960
+وهنا أكيد طبيعي مظهرياً، because typically he is
+
+272
+00:27:54,960 --> 00:28:02,000
+okay أو she is okay، فبالتالي لما نيجي ناخد أنه فيه
+
+273
+00:28:02,000 --> 00:28:10,290
+احتمالية ثلث إنه يكون normal، completely normal في
+
+274
+00:28:10,290 --> 00:28:16,690
+الحالة دي، لما يتزوج هنا راح يكون الثلث يعني أو
+
+275
+00:28:16,690 --> 00:28:27,370
+اللي بتضرب النسب ببعض بتكون هنا نصف carrier، ماشي؟
+
+276
+00:28:27,370 --> 00:28:32,530
+وبالنسبة للـ ... يعني الـ ... الـ ...
+
+277
+00:28:35,700 --> 00:28:45,140
+دقيقة، بالنسبة لما يكون الثلثين،
+
+278
+00:28:45,140 --> 00:28:52,160
+يعني هنا احنا هنا اللي لما تيجي تقول مثلاً سؤال شو
+
+279
+00:28:52,160 --> 00:28:57,200
+احتمالية إنه الجنين هذا اللي هنا يطلع completely
+
+280
+00:28:57,200 --> 00:29:02,040
+normal، صفر، لأنه أكيد راح يورث واحد من الجين
+
+281
+00:29:02,040 --> 00:29:07,070
+المضروب من أبوه، فإذن هو مستحيل يطلع normal، شو
+
+282
+00:29:07,070 --> 00:29:15,270
+احتمالية إنه يطلع carrier، ماشي، اللي لما يكون هذا
+
+283
+00:29:15,270 --> 00:29:19,150
+ثلث، فشو
+
+284
+00:29:19,150 --> 00:29:24,830
+اسمه؟ راح يكون أكيد 100% carrier لو كان الأم
+
+285
+00:29:24,830 --> 00:29:30,830
+completely normal، فهي ثلث، ولما
+
+286
+00:29:30,830 --> 00:29:39,100
+يكون الأم عندها ثلثين، احتمال إنها تكون carrier، مرة
+
+287
+00:29:39,100 --> 00:29:46,700
+بتعطي، يعني هي ثلثين، احتمالية إنها تكون carrier، نصف
+
+288
+00:29:46,700 --> 00:29:54,320
+الحالات تبع ثلثين بتعطي الجين أو الأليل المصاب، ففي
+
+289
+00:29:54,320 --> 00:29:59,540
+الحالة هذه، راح الطفل يكون مصاب، ونصف الاحتمالات راح
+
+290
+00:29:59,540 --> 00:30:04,090
+يكون، بتعطي النمط الطبيعي، فيطلع الطفل carrier
+
+291
+00:30:04,090 --> 00:30:11,370
+فبالنسبة للطفل هذا اللي أبوه مصاب وخالته مصابة
+
+292
+00:30:11,370 --> 00:30:17,970
+عنده احتمالية ثلث إنه يطلع مصاب، واحتمالية ثلثين
+
+293
+00:30:17,970 --> 00:30:23,010
+إنه يطلع carrier، واحتمالية صفر إنه يطلع completely
+
+294
+00:30:23,010 --> 00:30:27,450
+normal، فهدول النسب تبعته، فأول سؤال كان شو
+
+295
+00:30:27,450 --> 00:30:33,660
+احتمالية إنه يطلع مصاب، فهي ثلث، هذه النقطة اللي بدنا
+
+296
+00:30:33,660 --> 00:30:38,000
+إياها، أرجو أن تكونوا فاهمين، واللي سأل أن يكون
+
+297
+00:30:38,000 --> 00:30:47,420
+حاضر معنا في الشرح هذا، في أسئلة؟
+
+298
+00:30:47,420 --> 00:30:57,120
+دكتور كريم عندك أسئلة، اللي بدك إياها من
+
+299
+00:30:57,120 --> 00:30:59,000
+أنه ما رجع هذا ولا الثاني؟
+
+300
+00:31:01,630 --> 00:31:07,090
+من كتاب First Aid، ما عنديش يا First Aid ولا شو هو
+
+301
+00:31:07,090 --> 00:31:10,910
+من الـreferences اللي احنا حطيناهم ولا من محل
+
+302
+00:31:10,910 --> 00:31:14,350
+ثاني؟
+
+303
+00:31:14,350 --> 00:31:18,690
+لأ، هذا الكتاب نفسه، مش مرجع أسئلة نفس اللي معايا
+
+304
+00:31:18,690 --> 00:31:26,850
+هذا؟ لأ، مرجع أسئلة، ما هذا كله أسئلة في اللي هو
+
+305
+00:31:26,850 --> 00:31:32,480
+كتاب Kaplan USMLE Step One، اللي هو هيك
+
+306
+00:31:32,480 --> 00:31:39,780
+شكله، خليني، إيش اسمه؟  Resume shares؟ New shares؟
+
+307
+00:31:39,780 --> 00:31:48,120
+اللي هو هيك إن
+
+308
+00:31:48,120 --> 00:31:52,020
+شاء الله هيك واضح، Part Two Medical Genetics، هدول
+
+309
+00:31:52,020 --> 00:32:00,050
+اللي أعطوني إياها فيها بالـ ... بآخر الـ ... نعم، منفع أعمل
+
+310
+00:32:00,050 --> 00:32:06,370
+share scheme من عند دكتور؟ أعمل
+
+311
+00:32:06,370 --> 00:32:12,350
+share scheme من عندك؟ والله الدكتور اللي معانا إذا
+
+312
+00:32:12,350 --> 00:32:16,570
+بتقدر تكليك تعمل share scheme، أيوة، عمللي، عمللي بقى
+
+313
+00:32:16,570 --> 00:32:19,150
+منفع أعمل، طيب يالا عمللي
+
+314
+00:32:45,840 --> 00:32:53,680
+طيب، أيوة، اه، أنا عندي واضح، حسناً، تمام، في، في
+
+315
+00:32:53,680 --> 00:32:56,200
+أكثر الأمراض هدول مكررات في الـ First Aid، وشوية
+
+316
+00:32:56,200 --> 00:32:59,470
+حالاتهم بتفصيل يعني؟ وحتى في أسئلة الـ Review كان
+
+317
+00:32:59,470 --> 00:33:02,590
+بيسأل عنها وبيعطي تفاصيلهم كثير، فإذا ممكن تقدر
+
+318
+00:33:02,590 --> 00:33:09,050
+تشرحهم هنا، حسب ما هو شرحهم في الـ Test، شو اللي
+
+319
+00:33:09,050 --> 00:33:13,070
+مش مفهوم؟
+
+320
+00:33:13,070 --> 00:33:19,510
+يعني إذا بدك تشترك في  الـboards reviews، فيمشي عليه؟ إذا
+
+321
+00:33:19,510 --> 00:33:21,790
+بدك Cystic Fibrosis؟ يوجد Cystic Fibrosis، فيه
+
+322
+00:33:21,790 --> 00:33:26,130
+تحتوي أمراض ثانية، لأ، هدول مش أمراض، هدول
+
+323
+00:33:26,130 --> 00:33:49,750
+كيفية (incomplete sentence/unintelligible)
+
+324
+00:33:50,570 --> 00:34:01,990
+اللي هو يعني مرض في منطقتنا، مرض في الـ ... الـ ...
+
+325
+00:34:01,990 --> 00:34:06,910
+يعني في الـ ... اللي هو بيعتبرونا البيض احنا
+
+326
+00:34:06,910 --> 00:34:11,670
+كوكازيين، كوكازيين، أنا كوكازي  بالـgenetics تبع
+
+327
+00:34:11,670 --> 00:34:17,370
+العالم، يعني لما أنت بتكتب أنت، احنا مش Hispanic ولا
+
+328
+00:34:18,730 --> 00:34:24,050
+African ولا Native American اللي هو Eskimo أو إشي
+
+329
+00:34:24,050 --> 00:34:28,410
+زي ذلك، الآن
+
+330
+00:34:28,410 --> 00:34:36,210
+هذا مرض بسبب ... يعني أنا بتذكر أن في أستاذ إلي حكالي
+
+331
+00:34:36,210 --> 00:34:42,990
+عن أول حالة، هو شخصها، إنه الأم، وحكيت أنا كلمة
+
+332
+00:34:42,990 --> 00:34:51,070
+قدامكم، بتقول له، بلحس عرق الطفل تبعها اللي هو الجنين
+
+333
+00:34:51,070 --> 00:34:58,030
+أو الرضيع تبعها، بتقول له مالح كثير يا دكتور، يعني حتى
+
+334
+00:34:58,030 --> 00:35:03,550
+مرات هيك لما الواحد ينشف العرق على جبينه ولا كده
+
+335
+00:35:03,550 --> 00:35:09,790
+بتحس إنه فيه ملح، ففي مشكلة فيه، لقينا بعدين إنه
+
+336
+00:35:09,790 --> 00:35:17,280
+الـ Sodium Chloride Pump في الـ ... في الـ Mucous
+
+337
+00:35:17,280 --> 00:35:24,100
+Membranes فيها مشكلة، عرفتها؟ فاحنا الآن اللي
+
+338
+00:35:24,100 --> 00:35:29,180
+بنعرفه اللي هو إنه فيه Capital C و Capital F و
+
+339
+00:35:29,180 --> 00:35:33,580
+T و R اللي هو Cystic Fibrosis Transporter
+
+340
+00:35:33,580 --> 00:35:41,360
+Gene، ماشي، هاي الاختصار تبعه CFTR، طبعاً Gene
+
+341
+00:35:41,360 --> 00:35:50,020
+بمعنى إنه هنا، الجين تبعه، ماشي؟ لما نكتب مثلاً
+
+342
+00:35:50,020 --> 00:35:55,660
+عن البروتين أو عن الـ RNA أو كده، ما بنحطش capital
+
+343
+00:35:55,660 --> 00:36:02,060
+letter، بنحط small letter، فاللي هو autosomal
+
+344
+00:36:02,060 --> 00:36:06,580
+recessive defect بالـ Cystic Fibrosis Transporter
+
+345
+00:36:06,580 --> 00:36:12,760
+Gene، موجود على كروموزوم 7، فيه commonly deletion بـ
+
+346
+00:36:13,010 --> 00:36:18,710
+الـ phenylalanine بالـ Position 508، هذا الرمز اللي
+
+347
+00:36:18,710 --> 00:36:22,530
+حاطينه، it is the most common lethal disease in
+
+348
+00:36:22,530 --> 00:36:29,390
+Caucasian population، أكثر مرض قاتل في البيض
+
+349
+00:36:29,390 --> 00:36:37,770
+ورافقه، ماشي، هنا الآن الـ pathophysiology، يعني يمكن
+
+350
+00:36:37,770 --> 00:36:40,790
+نلقى Cystic Fibrosis Transporter Gene
+
+351
+00:36:40,790 --> 00:36:46,900
+Association أو الـ Linkage من الـ Linkage Studies
+
+352
+00:36:46,900 --> 00:36:51,740
+بس بعدين بدنا نفهم كيف بتسبب المرض، فالـ
+
+353
+00:36:51,740 --> 00:36:59,200
+pathophysiology إنه الـ ATP-gated chloride channel
+
+354
+00:36:59,200 --> 00:37:07,460
+اللي هي Sodium chloride channel، بالـ energy بدخله،
+
+355
+00:37:07,460 --> 00:37:12,840
+بيطلع Sodium وChloride، ماشي، في الـ Mucous Membranes
+
+356
+00:37:13,570 --> 00:37:18,070
+بيكون فيه defect، وهذا راح يأثر على الـ lungs والـ
+
+357
+00:37:18,070 --> 00:37:28,990
+GI tract، ماشي، فيه الآن يعني النتيجة إنه بيصير
+
+358
+00:37:28,990 --> 00:37:33,410
+عندنا mutations، misfolded protein، protein
+
+359
+00:37:33,410 --> 00:37:40,110
+retained in the rough endoplasmic reticulum، ولم يتم
+
+360
+00:37:40,110 --> 00:37:44,090
+توصيله إلى الـ cell membrane، بسبب أن الـ Chloride
+
+361
+00:37:44,090 --> 00:37:52,170
+بينزل والـ secretion للـ water بينزل، وبضل الـ
+
+362
+00:37:52,170 --> 00:37:56,430
+intracellular Chloride، result in compensatory
+
+363
+00:37:56,430 --> 00:38:02,290
+higher Sodium reabsorption، المهم، يعني في ميكانيزم
+
+364
+00:38:02,290 --> 00:38:08,370
+بخربط Sodium Chloride Pump في الـ Mucous Membrane
+
+365
+00:38:08,820 --> 00:38:13,380
+والـ Respiratory tract والـ GI tract حتى في الـ
+
+366
+00:38:13,380 --> 00:38:21,660
+Skin وحتى في الأشياء الثانية، فالآن كيف نشخصها؟ من
+
+367
+00:38:21,660 --> 00:38:27,700
+أوائل الـ tests اللي هي اللي هو اسمه الـ Chloride
+
+368
+00:38:27,700 --> 00:38:32,340
+يعني اللي بيسموه الـ sweat test، الـ sweat test
+
+369
+00:38:32,340 --> 00:38:40,730
+يعني  أول فحص، بيجيبوا الطفل، بيحطوه بمنشطة وبعدين
+
+370
+00:38:40,730 --> 00:38:46,590
+بيحطوا عليها إشي يمنع تبخر الماء، في حيث إنه يخلوه
+
+371
+00:38:46,590 --> 00:38:52,030
+يأرق، ويأخذوا العرق تبعه ويفحصوه لمستوى الـ
+
+372
+00:38:52,030 --> 00:38:57,470
+Chloride والسوديوم والأشياء هذه، فاللي هذا بيسموه
+
+373
+00:38:57,470 --> 00:39:03,730
+الـ Chloride Concentration in Pilocarpine Induced
+
+374
+00:39:03,730 --> 00:39:09,070
+Sweat Test، is diagnostic، مش كتير مفيد كتير كتير،
+
+375
+00:39:09,070 --> 00:39:13,810
+يعني في صعوبة إنك أنت تجمع كمية عرق من إنسان بيعرق
+
+376
+00:39:13,810 --> 00:39:21,090
+أو من طفل بيعرق، وتجمعها وبعدين تتحصّل مظبوط، يعني
+
+377
+00:39:21,090 --> 00:39:28,290
+اللي بتذكره، رقم الـ 60، إذا أعلى من 60 بالوحدات
+
+378
+00:39:28,290 --> 00:39:32,890
+تبعته، من ذاكرتي لسه، هذه بتكون ماشية مع التشخيص
+
+379
+00:39:32,890 --> 00:39:35,170
+هذا، فالـ
+
+380
+00:39:36,660 --> 00:39:45,760
+الـ ... الـ ... يعني هو إنسان راح يكون عنده مثلاً تكرار
+
+381
+00:39:45,760 --> 00:39:51,920
+التهابات بالصدر، خراب في وظيفة البنكرياس، وميل للـ
+
+382
+00:39:51,920 --> 00:39:59,260
+steatorrhea، وستاتورية، اللي هي المظاهر تبعتهم، ماشي، طبعاً
+
+383
+00:39:59,260 --> 00:40:10,580
+ممكن أنا أبحث للجين تبعه، ماشي، وفي اللي هو الـ
+
+384
+00:40:10,580 --> 00:40:14,340
+immunoreactive trypsinogen، newborn screening
+
+385
+00:40:14,340 --> 00:40:21,740
+method، إذا في عندك منطقة فيهم كثير، ماشي، فهي كيف
+
+386
+00:40:21,740 --> 00:40:25,160
+بنسوي التشخيص، بس يعني غير إنك تدور على الـ gene
+
+387
+00:40:25,160 --> 00:40:30,220
+mutation، بتقدر تسوي له sweat test، هذا اللي بنقوله
+
+388
+00:40:30,670 --> 00:40:38,870
+وفيه trypsinogen level، يعني بيكون increased مع
+
+389
+00:40:38,870 --> 00:40:45,770
+الكلوراسيس والـ hypocalcemia، هذول لأنه يعني المرض
+
+390
+00:40:45,770 --> 00:40:50,330
+راح يخلي الـ chloride والـ sodium ينفرزوا برا
+
+391
+00:40:50,330 --> 00:40:58,980
+فالجسم بيحاول يسحبهم لجوا عشان يصير اتزان، فلما يصير
+
+392
+00:40:58,980 --> 00:41:03,920
+هذه الشغلة، زي لما مثلاً واحد يأخذ Mineralocorticoid
+
+393
+00:41:03,920 --> 00:41:10,360
+أو كده، نتيجة الموضوع هذا إنه عشان أنا أسحب في
+
+394
+00:41:10,360 --> 00:41:15,680
+الـ K  و في الـ ... يعني احنا هنا بنحكي عن الـ CFTR
+
+395
+00:41:15,680 --> 00:41:22,640
+جين في الـ Mucous Membranes والـ GI
+
+396
+00:41:22,640 --> 00:41:26,810
+tract، يعني الـ Respiratory tract والـ GI tract، عندما
+
+397
+00:41:26,81
+
+445
+00:45:47,420 --> 00:45:50,900
+بحاول أساعد المريضة بفعل chest physical therapy
+
+446
+00:45:50,900 --> 00:45:57,400
+بعطيه bronchodilator  وأحاول إذابة الـ mucus لأنه
+
+447
+00:45:57,400 --> 00:46:02,540
+thick و very thick  يسمى هذا الـDNA  يعني عبارة عن
+
+448
+00:46:02,540 --> 00:46:07,820
+enzyme aerosolized يعني يُحَطّ بالنفس عشان يعني
+
+449
+00:46:07,820 --> 00:46:11,820
+يذوب الـ mucus
+
+450
+00:46:11,820 --> 00:46:12,160
+
+451
+00:46:12,160 --> 00:46:13,360
+
+452
+00:46:13,360 --> 00:46:14,220
+
+453
+00:46:14,220 --> 00:46:15,000
+
+454
+00:46:15,000 --> 00:46:17,020
+
+455
+00:46:17,020 --> 00:46:19,200
+
+456
+00:46:19,200 --> 00:46:23,720
+
+457
+00:46:23,720 --> 00:46:28,300
+
+458
+00:46:28,300 --> 00:46:35,120
+المهم، هذا المرض الأول،  ماذا بعده؟ إذا في
+
+459
+00:46:35,120 --> 00:46:39,140
+أسئلة، يعني هذا Cystic Fibrosis موجود في كتابكم،
+
+460
+00:46:39,140 --> 00:46:44,780
+موجود هنا،  تمام،  موافق، وهذه التي تُسمّى  Extinct
+
+461
+00:46:44,780 --> 00:46:51,240
+Recessive Disorder،  موافق، آسف،  التي نتحدث عنها هي Autism
+
+462
+00:46:51,240 --> 00:46:56,480
+Recessive،  أيّ Cystic Fibrosis، هنا نضع ماذا؟
+
+463
+00:46:56,480 --> 00:47:03,860
+اسمه Extinct Recessive،  موافق،  مرض Duchenne
+
+464
+00:47:03,860 --> 00:47:13,880
+Dystrophy هذا، نعم،  Duchenne،  ما اسمه؟  هناك عبارة
+
+465
+00:47:13,880 --> 00:47:23,530
+عن جين مسؤول عن البروتين dystrophin هذا هو
+
+466
+00:47:23,530 --> 00:47:31,490
+بروتين موجود في العضلات  لـ actin
+
+467
+00:47:31,490 --> 00:47:35,770
+و myosin  اللذان هما البروتينات التي تُكوّن الـ
+
+468
+00:47:35,770 --> 00:47:41,970
+عضلات  وتُمكّنها من العمل،  موافق،  هناك
+
+469
+00:47:41,970 --> 00:47:44,330
+مشكلة،  موافق
+
+470
+00:47:45,940 --> 00:47:50,660
+فبالنهاية يؤثر على Intracellular Cytoskeleton
+
+471
+00:47:50,660 --> 00:47:57,180
+الذي هو Actin،  ماذا؟  وله أكثر من عمل،  الآن
+
+472
+00:47:57,180 --> 00:48:05,200
+
+473
+00:48:05,200 --> 00:48:05,220
+
+474
+00:48:05,220 --> 00:48:05,360
+
+475
+00:48:05,360 --> 00:48:05,940
+
+476
+00:48:05,940 --> 00:48:08,640
+
+477
+00:48:08,640 --> 00:48:19,400
+وهو مسؤول عن dystrophin،  موافق؟
+
+478
+00:48:19,400 --> 00:48:24,120
+وهذا نضعه كـdeleted dystrophin، يعني
+
+479
+00:48:24,120 --> 00:48:28,320
+الـ dystrophin،  وهو البروتين اللازم لوظيفة
+
+480
+00:48:28,320 --> 00:48:35,560
+العضلات مفقود،  وقد حدث له deletion،  موافق؟  الآن
+
+481
+00:48:35,560 --> 00:48:41,620
+بالنسبة لمثل هذا المرض الـ
+
+482
+00:48:43,000 --> 00:48:51,260
+هناك عدة أعراض،  النقطة الأولى  والأخيرة
+
+483
+00:48:51,260 --> 00:48:56,600
+هو وجود muscle weakness،  يعني الطفل لا يجلس طبعاً
+
+484
+00:48:56,600 --> 00:49:02,600
+الـ Duchenne،  الذي هو النوع الشديد منه،  يوجد فيه issue يُسمّى
+
+485
+00:49:02,600 --> 00:49:11,220
+Becker muscular dystrophy،  الـ Becker  مثل الـ Duchenne، لكن الـ Duchenne
+
+486
+00:49:11,220 --> 00:49:20,190
+أشد،  ويظهر من الطفولة،  ولا يطول،  الـ Becker يظهر لاحقاً، يعني
+
+487
+00:49:20,190 --> 00:49:26,090
+يظهر مثلاً،  يعني الـ Duchenne  من المستحيل تقريباً أن يصلوا فوق
+
+488
+00:49:26,090 --> 00:49:34,430
+الـ 12 سنة،  يعني ما اسمه؟  سيموتون
+
+489
+00:49:34,430 --> 00:49:39,220
+بشكل مبكر، وأهم مكان تتلف فيه العضلات هو  القصبات
+
+490
+00:49:39,220 --> 00:49:44,120
+أو العضلات التنفسية، أو  القدرة على الوقوف أو المشي، أو
+
+491
+00:49:44,120 --> 00:49:50,760
+كذلك،  فـ Duchenne أشد  ويموتون بسرعة
+
+492
+00:49:50,760 --> 00:50:01,380
+في الـ Becker  يبدأ متأخراً  ويطول أكثر
+
+493
+00:50:01,380 --> 00:50:11,330
+موافق، الآن الـ Duchenne نتيجة تلف الـ
+
+494
+00:50:11,330 --> 00:50:16,230
+muscle protein،  تَطوّر الحركة  يصبح
+
+495
+00:50:16,230 --> 00:50:22,590
+ضعيفاً،  بطبيعة الحال،  جزء منه نقول pseudo
+
+496
+00:50:22,590 --> 00:50:28,670
+hypertrophy،  يعني ماذا؟  الذي هو hypertrophy
+
+497
+00:50:28,670 --> 00:50:35,200
+تضخم، لكن هذا تضخم كاذب، يعني  إذا إنسان طبيعي  يذهب
+
+498
+00:50:35,200 --> 00:50:41,080
+إلى الصالة الرياضية،  يُقوّي عضلاته  ويتمرّن
+
+499
+00:50:41,080 --> 00:50:47,380
+ويُقوّيها،  تتضخم العضلات وتكبر،  تستجيب للتمرين،  فهي
+
+500
+00:50:47,380 --> 00:50:52,780
+true hypertrophy،  موافق،  تكون عضلاته قوية
+
+501
+00:50:52,780 --> 00:50:58,760
+أما الذي لديه Duchenne  يكون شكل العضلات كبيراً، لكن
+
+502
+00:50:58,760 --> 00:51:03,060
+هي عضلات ضعيفة،  لذلك تُسمّى pseudo hypertrophy
+
+503
+00:51:03,550 --> 00:51:12,830
+هناك صورة في كتابكم،  الذي هو  "Thompson"، يضع
+
+504
+00:51:12,830 --> 00:51:18,990
+هكذا ساق واحدة  وأخرى كبيرة، لكن ضعيفة،  موافق؟  فلنقل
+
+505
+00:51:18,990 --> 00:51:23,470
+Calf pseudo-hypertrophy،  الـ"h" الثانية
+
+506
+00:51:23,470 --> 00:51:27,930
+لديه علامة مميزة،  وهي Gower sign،  التي
+
+507
+00:51:27,930 --> 00:51:34,530
+وضعناها لكم هنا،  أنه عندما
+
+508
+00:51:34,530 --> 00:51:42,930
+يُرفَع الطفل قليلاً،  عندما يريد الوقوف،  موافق،  عندما يريد الوقوف  كأنه
+
+509
+00:51:42,930 --> 00:51:50,050
+يتسلق نفسه،  يعني يكون نائماً على ظهره  ويريد
+
+510
+00:51:50,050 --> 00:51:56,970
+الوقوف،  فماذا يفعل؟  يكون نائماً على ظهره أولاً،  ثم ينقلب على
+
+511
+00:51:56,970 --> 00:52:02,930
+بطنه،  يُرفَع رأسه أولاً،  ثم يحاول حمل نفسه
+
+512
+00:52:02,930 --> 00:52:08,450
+بهذه الطريقة،  ثم يستخدم يديه ليرتكز على
+
+513
+00:52:08,450 --> 00:52:14,950
+ساقيه  ليُقوّم نفسه،  موافق؟  فهي تُسمّى
+
+514
+00:52:14,950 --> 00:52:20,150
+Gower sign،  التي هي patient uses upper extremity
+
+515
+00:52:20,150 --> 00:52:25,430
+to help stand up،  يعني يتسلق نفسه بهذه الطريقة
+
+516
+00:52:25,430 --> 00:52:31,340
+عندما ترى طفلاً أو إنساناً يقف بهذه الطريقة،  مع
+
+517
+00:52:31,340 --> 00:52:34,960
+Muscular Disabilities،  مع Muscle Weakness،  مع
+
+518
+00:52:34,960 --> 00:52:42,220
+Duchenne  كطفل صغير،  موافق؟  فهذه تُسمّى
+
+519
+00:52:42,220 --> 00:52:49,120
+Gower sign،  موافق؟  الآن نتيجة المشاكل في
+
+520
+00:52:49,120 --> 00:52:56,270
+Muscle Fibers و Muscle Proteins،  وكذلك الـ
+
+521
+00:52:56,270 --> 00:52:59,870
+CPK،  الأنزيم الخاص بـ creatinine kinase أو
+
+522
+00:52:59,870 --> 00:53:05,470
+phosphocreatine kinase  يصبح مرتفعاً،  وهذا كان من المظاهر أنه
+
+523
+00:53:05,470 --> 00:53:12,050
+هناك مشكلة  في العضلات،
+
+524
+00:53:12,050 --> 00:53:18,630
+موافق؟  الآن نحن،  دعوني أذكركم بشيء، هذا X-linked
+
+525
+00:53:18,630 --> 00:53:23,730
+recessive،  يعني الأولاد هم من يُصابون، وأذهب أسأل عن
+
+526
+00:53:23,730 --> 00:53:29,240
+أخوهم،  موافق،  أسأل عن خالته، أيّ اللي  ستكون والـ
+
+527
+00:53:29,240 --> 00:53:36,120
+females  يكونون حاملات،  موافق، females والله هناك
+
+528
+00:53:36,120 --> 00:53:44,040
+واحدة لديها Duchenne  وهي Turner،  موافق، ليس لديها إلاّ
+
+529
+00:53:44,040 --> 00:53:49,060
+نسخة واحدة من X،  ممكن،  ممكن أن تكون لديها، لكن تكون
+
+530
+00:53:49,060 --> 00:53:57,560
+غير معتادة،  ننزل إلى الـ Becker، مثل الـ Duchenne لكن يبدأ بـ
+
+531
+00:53:57,560 --> 00:54:05,740
+يعني هو نوع آخر، ويبدأ  في مرحلة
+
+532
+00:54:05,740 --> 00:54:12,260
+متأخرة،  يعني الـ Duchenne  عادةً مايصل  إلى
+
+533
+00:54:12,260 --> 00:54:18,780
+سن الـ 12 سنة،  يدخل  مرحلة المراهقة  يعني
+
+534
+00:54:18,780 --> 00:54:23,600
+مرحلة المراهقة،  فـ Becker  نوع آخر من نفس المشكلة
+
+535
+00:54:24,150 --> 00:54:30,930
+ويكون  بداية المرض متأخرة  عن الـ Becker  وعن الـ Duchenne
+
+536
+00:54:30,930 --> 00:54:41,950
+والمريض يعيش أكثر،  موافق،  هناك ما يُسمّى Myotonia، نحن
+
+537
+00:54:41,950 --> 00:54:50,010
+هنا هدف هذه الدورة  بشكل خاص  الجينات، وليس
+
+538
+00:54:50,010 --> 00:54:55,460
+الأمراض،  موافق،  يعني من يعرف عن
+
+539
+00:54:55,460 --> 00:54:58,960
+الـ Disease يفهم الـ Genetics أكثر، صحيح، وإن
+
+540
+00:54:58,960 --> 00:55:03,660
+من اقترب منها صحيح، لكنني أعتقد أنه يعني
+
+541
+00:55:03,660 --> 00:55:10,360
+فلنذكر علاقة الـ manifestation  والجينات
+
+542
+00:55:10,360 --> 00:55:18,020
+والظواهر مع الجينات، وما علاقتها،  الـ Becker أخف،  الـ Duchenne أقوى
+
+543
+00:55:18,020 --> 00:55:29,620
+وأشد،  موافق،  و الـ Myotonia  عبارة عن حالة التي
+
+544
+00:55:29,620 --> 00:55:38,040
+تعريفها،  إذا تذكر  الـ Physiology  لـ
+
+545
+00:55:38,040 --> 00:55:43,560
+العضلات وكيف تصاب العضلات بـ Contracture
+
+546
+00:55:43,560 --> 00:55:54,390
+العضلة،  يجب أن تتذكر أن العضلة  الـ ATP والطاقة
+
+547
+00:55:54,390 --> 00:56:01,870
+في مرحلة الانفصال،  يعني أنت  العضلات تجد
+
+548
+00:56:01,870 --> 00:56:08,550
+مثلاً هذا actin وهذا myosin  خيوط تجدها عندما
+
+549
+00:56:08,550 --> 00:56:16,170
+العضلة مثلاً تنقبض،  تنزلق فوق بعضها،  ثم تقصر وتقترب
+
+550
+00:56:16,170 --> 00:56:19,970
+أكثر  إلى بعضها،  مثلاً تكون هكذا في البداية  بعيدة عن
+
+551
+00:56:19,970 --> 00:56:24,880
+بعضها،  الـ Energy  اللازمة لكي تنفصل عن بعضها
+
+552
+00:56:24,880 --> 00:56:28,800
+ثم تقترب  إلى بعضها وتمسك بشكل أقوى،  هكذا يحدث
+
+553
+00:56:28,800 --> 00:56:35,560
+الـ Contraction،  فالـ Myotonia  هي أن العضلة لا
+
+554
+00:56:35,560 --> 00:56:42,140
+تسترخي،  تجد العضلة مشدودة،
+
+555
+00:56:42,140 --> 00:56:47,020
+موافق؟  مثلاً هنا  سأضع لكم  تعريف الـ
+
+556
+00:56:47,020 --> 00:56:53,060
+Myotonia، يعني تأتي إلى إنسان، تصافحه،  يُشدّ
+
+557
+00:56:53,060 --> 00:57:02,860
+يده،  لا يستطيع فكّها،  هكذا تصافحه،  موافق،  ماذا بعد؟
+
+558
+00:57:02,860 --> 00:57:08,580
+ثم هنا  Autosomal Dominant،  أنا لا أعرف لماذا
+
+559
+00:57:08,580 --> 00:57:17,190
+وضعناها هنا،  وهي  Myotonia،  هذه الثلاثة أمراض عضلية
+
+560
+00:57:17,190 --> 00:57:22,910
+عضلية،  لكن الـ Becker  و الـ Duchenne  X-linked recessive،  الـ
+
+561
+00:57:22,910 --> 00:57:26,990
+Myotonia أتذكر Autosomal Dominant،  الأصل ليس
+
+562
+00:57:26,990 --> 00:57:30,690
+واحداً،  لكن كلها أمراض  في العضلات،  هذا ما
+
+563
+00:57:30,690 --> 00:57:34,370
+يجب أن تتذكره،  والله  لا أتذكر Early balding
+
+564
+00:57:34,370 --> 00:57:41,850
+in men،  يعني إذا واحد صلع  بسرعة  أو صلع
+
+565
+00:57:41,850 --> 00:57:48,550
+مبكراً،  وكان هذا الـ Atrophy  والحالة الثالثة  CTG
+
+566
+00:57:48,550 --> 00:57:56,290
+وهذه Tri-Nucleotide Repeat Expansion،  ممكن
+
+567
+00:57:56,290 --> 00:58:00,970
+Duchenne Muscular dystrophy  لا أعرف لماذا  يعني ماذا،  ممكن
+
+568
+00:58:00,970 --> 00:58:08,750
+لـ Duchenne،  موافق
+
+569
+00:58:10,650 --> 00:58:17,630
+يعني هذا الشيء يجب أن تتذكره،  CTG  هو Tri-Nucleotide
+
+570
+00:58:17,630 --> 00:58:22,350
+Repeat، وفي نفس الوقت أن الـ Myotonia يحدث معهم
+
+571
+00:58:22,350 --> 00:58:28,350
+كثيرا،  يُصبح لديهم  صلع،  يُصبح لديهم  صلع  ويحدث
+
+572
+00:58:28,350 --> 00:58:34,230
+عندهم صلع  وتتأثر الـ Gonads  بشكل مبكر،  هذه كلها مع الـ Myotonia،  فهذه "my
+
+573
+00:58:34,230 --> 00:58:40,680
+otonia type 1"،  يعني هناك أكثر من نوع،  أجل،
+
+574
+00:58:40,680 --> 00:58:45,820
+أكمل، هذا Myotonia،
+
+575
+00:58:45,820 --> 00:58:52,340
+أجل،  حسناً،  الـ  يعني،  انظر، بالنسبة لأهداف امتحانكم
+
+576
+00:58:52,340 --> 00:59:04,980
+معاً،  كثير من هذه الأمراض،  كنتُ أُريد أن يعني إذا
+
+577
+00:59:04,980 --> 00:59:12,090
+أنتم  ليس لديكم خلفية سريرية، يعني  أمراض
+
+578
+00:59:12,090 --> 00:59:18,770
+لديكم هكذا معلومات طبية أكبر، يعني لا داعي لدخول
+
+579
+00:59:18,770 --> 00:59:26,110
+كثيرا في التفاصيل،  ما هو هذا المرض وما هو هذا المرض وكذا
+
+580
+00:59:26,110 --> 00:59:29,810
+وهكذا،  لكن ما هو مطلوب هو أن تتذكر أو تحفظ قدر ما
+
+581
+00:59:29,810 --> 00:59:35,600
+تستطيع معرفته أكثر،  أكثر، وهي الجينات
+
+582
+00:59:35,600 --> 00:59:40,700
+تبعاتها،  موافق؟  مثلاً  Fragile X-Syndrome أو
+
+583
+00:59:40,700 --> 00:59:47,780
+Rett Syndrome،  الذي هو Rett،  والله أنا لم أكن
+
+584
+00:59:47,780 --> 00:59:54,080
+أعرفه من قبل،  أو لا أتذكره، Sporadic disorder seen
+
+585
+00:59:54,080 --> 00:59:58,300
+almost exclusively in girls،  
+
+586
+00:59:58,300 --> 01:00:03,050
+
+587
+01:00:03,050 --> 01:00:07,330
+
+588
+01:00:07,330 --> 01:00:13,190
+
+589
+01:00:13,190 --> 01:00:13,530
+
+590
+01:00:13,530 --> 01:00:14,330
+
+591
+01:00:14,330 --> 01:00:15,310
+
+592
+01:00:15,310 --> 01:00:22,430
+
+593
+01:00:22,430 --> 01:00:27,500
+Motor،  Verbal،  Cognitive
+
+594
+01:00:27,500 --> 01:00:30,280
+Abilities،  Ataxia،  Seizures،  Growth
+
+595
+01:00:30,280 --> 01:00:34,840
+retardation،  Stereotypies،  Hand-wringing،
+
+596
+01:00:34,840 --> 01:00:38,060
+Hand-wringing،
+
+597
+01:00:38,060 --> 01:00:42,900
+Regression،  ممكن يا دكتور،  Fragile X Syndrome،
+
+598
+01:00:42,900 --> 01:00:46,480
+هذا ربما كرر كثيراً في الأسئلة،  يعني إذا اكتشفت
+
+599
+01:00:46,480 --> 01:00:49,980
+أعراض هذا  Syndrome،  Fragile X،  Fragile  ممكن
+
+600
+01:00:49,980 --> 01:00:57,030
+اكتشافها  في العالم،  فلنأخذه،  اسمه  regression،  موافق
+
+601
+01:00:57,030 --> 01:01:03,610
+الذي هو يعني التراجع،  يعني في الأطفال  أنا لستُ
+
+602
+01:01:03,610 --> 01:01:08,130
+طبيب أطفال، لكن  في الأطفال  الـ milestones  للطفل
+
+603
+01:01:08,130 --> 01:01:15,030
+يعني متى عند الولادة،  أو بعد الولادة  على
+
+604
+01:01:15,030 --> 01:01:18,810
+أي مدة  وهذه  الـ milestones  الضرورية، ويجب أن يتحرك
+
+605
+01:01:18,810 --> 01:01:23,640
+متى الطفل  يقلب على بطنه  إذا وضعته على ظهره
+
+606
+01:01:23,640 --> 01:01:27,700
+متى يستطيع الجلوس؟  متى يستطيع الزحف؟  متى يستطيع الوقوف؟
+
+607
+01:01:27,700 --> 01:01:32,220
+متى يستطيع المشي؟  هذه كلها motor milestones
+
+608
+01:01:32,220 --> 01:01:36,980
+يعني مهارات
+
+609
+01:01:36,980 --> 01:01:46,700
+حركية،  لها تواريخ محددة،  يجب أن يكتسبها الطفل بشكل طبيعي
+
+610
+01:01:46,700 --> 01:01:52,060
+يكتسبها،  مهارات جديدة،  فإذا كان مثلاً طفلاً
+
+611
+01:01:52,060 --> 01:01:59,080
+كان يستطيع  القلوب،  لم يعد يستطيع،  كان يستطيع الجلوس،  لم يعد يستطيع الجلوس،
+
+612
+01:01:59,080 --> 01:02:03,200
+كان يستطيع الوقوف،  لم يعد يستطيع الوقوف،  لم يعد يستطيع المشي،  كان
+
+613
+01:02:03,200 --> 01:02:08,920
+يستطيع الركض،  وهكذا،  هذه كلها Motor Skills،  إذا
+
+614
+01:02:08,920 --> 01:02:13,220
+حدث فيها تراجع،  نسميه Regression،  في نفس الوقت
+
+615
+01:02:13,220 --> 01:02:19,140
+الـ Verbal،  بدأ يتكلم بابا،  ماما،  أولاً،  يجب أن
+
+616
+01:02:19,630 --> 01:02:24,010
+ثم بابا،  ثم مثلاً  يبدأ يتكلم  باقي الكلمات
+
+617
+01:02:24,010 --> 01:02:29,9
+
+667
+01:07:45,510 --> 01:07:50,730
+الشيء وفي الحالة هذه بتلاقي بيجي يركض على الأطباء
+
+668
+01:07:50,730 --> 01:07:54,870
+«شو أعمل؟» «شو أسوي؟» في ناس في دول كثيرة بتلاقي
+
+669
+01:07:54,870 --> 01:08:00,810
+بنتحر، ولا كده ولا هيك، يعني فبتلاقي فيه مشكلة
+
+670
+01:08:03,650 --> 01:08:09,090
+يعني هي إشكالية لها جانب أخلاقي، إنه أنت شخص بتلاقيه
+
+671
+01:08:09,090 --> 01:08:13,950
+كبيرًا بالعمر، أربعين سنة، ويقول لك لأن أبوه مات عمره
+
+672
+01:08:13,950 --> 01:08:20,990
+ستين أو خمس وخمسين، بموت صعب، بالشلل، بطريقة عاشية
+
+673
+01:08:20,990 --> 01:08:26,470
+وفيها مشكلة، فبيقول لك: طب أنا شو احتمالية أن أكون
+
+674
+01:08:26,470 --> 01:08:33,610
+حامل المرض هذا؟ فهذا المرض اتّسامٌ سائد (dominant) يعني
+
+675
+01:08:33,610 --> 01:08:39,690
+فيه مشكلة، وبعدين إذا هو تزوّج، يمكن يأخر زواجه، يمكن
+
+676
+01:08:39,690 --> 01:08:45,450
+ما يَرْزُقْش، يخلف، لأنه خائف 50% chance  يعطي الطفل، أو
+
+677
+01:08:45,450 --> 01:08:58,890
+يروح يتحصل، يعمل IVF، ويسوي نوع من الدراسة لقضية: هل
+
+678
+01:08:58,890 --> 01:09:06,430
+هو الجنين مصاب ولا مش مصاب؟ كل هذه بتكون موجودة، هو
+
+679
+01:09:06,430 --> 01:09:13,550
+أنا صراحة حاطّط لكم يعني،  Huntington's disease،
+
+680
+01:09:13,550 --> 01:09:19,190
+Myotonic Dystrophy، وحاطّط لكم Friedreich's Ataxia،
+
+681
+01:09:19,190 --> 01:09:23,830
+وكمان  Fragile X-Syndrome، اتكلمنا عنه برضه، mental
+
+682
+01:09:23,830 --> 01:09:31,100
+deficiency، ويعني بقدر يخلف عَقَلَ، Friedreich's
+
+683
+01:09:31,100 --> 01:09:36,940
+ataxia، يعني أنا بتذكرها في الطب، بتعطي مشاكل في
+
+684
+01:09:36,940 --> 01:09:45,520
+القلب، بتعطي شو اسمه؟ إذا بتأخذ بالعصاب، Upper motor
+
+685
+01:09:45,520 --> 01:09:50,200
+neuron lesion،  Friedreich's ataxia من أسباب الـ
+
+686
+01:09:50,200 --> 01:09:54,860
+BOTH، إنه في نفس الإنسان Upper motor و Lower motor
+
+687
+01:09:54,860 --> 01:10:00,380
+neuron lesion، في أي ناحية، الـ Upper Motor Neuron
+
+688
+01:10:00,380 --> 01:10:04,400
+lesion بيعمل Spasticity، بيعمل Exaggerated Reflexes،
+
+689
+01:10:04,400 --> 01:10:10,480
+بيعمل كده، فالـ والعكس، الـ Lower Motor Neuron
+
+690
+01:10:10,480 --> 01:10:17,060
+lesion بتعمل Flaccidity، يعني هيك بتلاقي العضلات
+
+691
+01:10:17,060 --> 01:10:22,980
+رخوة، زي إذا طفل أو إنسان عنده مثلًا البوليو اللي هو
+
+692
+01:10:22,980 --> 01:10:31,390
+شلل الأطفال، وبتلاقي Absent Reflexes، وكده، أنا بتوقع،
+
+693
+01:10:31,390 --> 01:10:37,930
+بتوقع إنه الـ الـ هنا، دولة، الثلاثة أو أربعة أمراض
+
+694
+01:10:37,930 --> 01:10:42,390
+حاطط إنه الـ Trinucleotide Repeat Expansion
+
+695
+01:10:42,390 --> 01:10:51,270
+Disease، يعني فيه protein أو جين أو شيء بيصير الـ
+
+696
+01:10:51,270 --> 01:10:58,330
+شو اسمه؟ بيصير تلفّات من الـ من الـ Nucleotides،
+
+697
+01:10:59,130 --> 01:11:05,290
+بيصير لهم insertion، زيادة في المرات،
+
+698
+01:11:05,290 --> 01:11:10,930
+بتخرب وظيفة البروتين، إنه كذا amino acid أو كذا شيء،
+
+699
+01:11:10,930 --> 01:11:17,030
+بالحق مش المفروض يكون محتوى، بس يعني مرتبط بكمية،
+
+700
+01:11:17,030 --> 01:11:21,430
+يعني مش زي الـ sickle cell، إنه one nucleotide اللي
+
+701
+01:11:21,430 --> 01:11:28,090
+متغير سبب المرض، فالـ repeats هو أنا حاططها بالـ N،
+
+702
+01:11:29,560 --> 01:11:35,520
+رابطين كل مرض بـ «CAG»
+
+703
+01:11:35,520 --> 01:11:39,300
+«CAG» «CAG» «CAG» «CAG» «CAG» «CAG» «CAG» «CAG» «CAG» «CAG»
+
+704
+01:11:39,300 --> 01:11:41,460
+«CAG» «CAG» «CAG» «CAG» «CAG» «CAG» «CAG» «CAG» «CAG» «CAG»
+
+705
+01:11:41,460 --> 01:11:44,640
+«CAG» «CAG» «CAG» «CAG» «CAG» «CAG» «CAG» «CAG» «CAG» «CAG»
+
+706
+01:11:44,640 --> 01:11:44,800
+«CAG» «CAG» «CAG» «CAG» «CAG» «CAG» «CAG» «CAG» «CAG» «CAG»
+
+707
+01:11:44,800 --> 01:11:46,820
+«CAG» «CAG» «CAG» «CAG» «CAG» «CAG» «CAG» «CAG» «CAG» «CAG»
+
+708
+01:11:46,820 --> 01:11:55,940
+«CAG» «CAG» «CAG»
+
+709
+01:11:57,060 --> 01:12:01,580
+يعني أنا من الأشياء اللي شفتها وقلت لكم أن تتبعوا
+
+710
+01:12:01,580 --> 01:12:07,840
+عليها اللي هي الـ Stop codon تبع الـ تبع الـ
+
+711
+01:12:07,840 --> 01:12:12,940
+الـ triplets، دولة، تبع الـ Tri-nucleotides، لما نيجي
+
+712
+01:12:12,940 --> 01:12:18,000
+ثلاثة اللي بيقشروا على إنه أي Stop فيه ثلاثة
+
+713
+01:12:18,000 --> 01:12:25,380
+Repeats من الـ 64 possible triplets،
+
+714
+01:12:25,380 --> 01:12:33,180
+ماشي؟ فهذولا الـ يعني حتى هنا بيحاولوا يساعدوكم
+
+715
+01:12:33,180 --> 01:12:39,000
+إنه يعطيكم الـ mnemonics تبعتها، كيف تربطها، وهي في
+
+716
+01:12:39,000 --> 01:12:43,400
+الطب ضرورية يعني،
+
+717
+01:12:43,400 --> 01:12:47,140
+الـ Try
+
+718
+01:12:47,140 --> 01:12:52,960
+nucleotide، أنا بحاول أشوف: «Try hunting for my
+
+719
+01:12:52,960 --> 01:13:01,620
+fragile cage-free egg»، X، يعني هاي كلمات، يعني هاي
+
+720
+01:13:01,620 --> 01:13:07,400
+أسلوب، إذا بتلاقوا شيء وحاولوا تحفظوها بتفيد، بتفيد،
+
+721
+01:13:07,400 --> 01:13:13,100
+يعني أنا مثلًا كنت بالـ Anatomy شاطر، الـ Anatomy كنا
+
+722
+01:13:13,100 --> 01:13:16,220
+الله يرضى عليهم أساتذتنا، أو بكثير من المصريين،
+
+723
+01:13:16,220 --> 01:13:22,240
+يحاولوا يحفظونا الأشياء تحتها، فكان مثلًا شو أسماء
+
+724
+01:13:22,240 --> 01:13:29,800
+عظام الـ ankle، والله صعب، بس كان فيه دكتور، الله يرفَع
+
+725
+01:13:29,800 --> 01:13:34,460
+عليه ويرحمه، الآن يقول: تفيد، كلت كشري ناشف، وثلاث
+
+726
+01:13:34,460 --> 01:13:42,400
+كتاكيت، تالوس، كالكانيوس، كونيفورم، كيوبيفورم، مش
+
+727
+01:13:42,400 --> 01:13:45,900
+عارف إيش، بس هي يعني الـ الـ الـ الـ mnemonic
+
+728
+01:13:45,900 --> 01:13:52,720
+تبعتها، طريقة الحفظ هذه مفيدة وكويسة، فاللي حاططينه
+
+729
+01:13:52,720 --> 01:14:01,260
+لكم، عليه أحمر، كويس، Tri-nucleotide Hunting for My
+
+730
+01:14:01,260 --> 01:14:12,520
+Fragile Cage-Free Eggs, Myotonic
+
+731
+01:14:12,520 --> 01:14:21,100
+Hunting، يعني الـ Tri-nucleotide Hunting اللي هي
+
+732
+01:14:21,100 --> 01:14:28,720
+Hunting، في كوريا، أو Disease، اللي هي Myotonia، cage
+
+733
+01:14:28,720 --> 01:14:35,540
+-free، اللي هي Fragile X، و Fragile، يمكن Fredericks،
+
+734
+01:14:35,540 --> 01:14:43,360
+ماشي، أو Fragile، للاثنتين، free، اللي هي Fragile أو
+
+735
+01:14:43,360 --> 01:14:52,200
+free، مش عارف free، Fredericks، يعني فهذه جزء يعني
+
+736
+01:14:53,910 --> 01:14:58,090
+للامتحانات الـ USMLE، كويس الواحد ينتبه لها، إن
+
+737
+01:14:58,090 --> 01:15:01,410
+هدول أربعة أمراض، الـ Tri-nucleotide Repeat
+
+738
+01:15:01,410 --> 01:15:07,130
+Expansion Diseases، وهدول الأمثلة تبعتها، كويسة،
+
+739
+01:15:07,130 --> 01:15:10,990
+يعني تستفيدوا منها إن شاء الله، إذا الواحد بيقدر
+
+740
+01:15:10,990 --> 01:15:16,550
+يحفظ الـ الـ شو هي الـ repeat تبعت كل مرض، يمكن إن
+
+741
+01:15:16,550 --> 01:15:20,810
+شاء الله بتجيب نسب عالية، وأحسن، وشكلها مركزين عليها،
+
+742
+01:15:22,890 --> 01:15:28,250
+الملاحظة، الـ هانتنغتون والـ مايتونيا اتّسامٌ سائد،
+
+743
+01:15:28,250 --> 01:15:32,390
+dominant، رجال الـ X-syndrome، X-linked dominant، X
+
+744
+01:15:32,390 --> 01:15:36,330
+-linked dominant، الـ فريدريكس أتاكسيا اتّسامٌ متنحي،
+
+745
+01:15:36,330 --> 01:15:45,730
+recessive، يعني مهمة، بدي أحفظ لخياهم شو الـ
+
+746
+01:15:45,730 --> 01:15:49,870
+tri-nucleotides، فريدريكس أتاكسيا attacks الـ gate،
+
+747
+01:15:51,270 --> 01:16:00,270
+فـ GAA حاططها ماشي، Fragile Eggs، Shin، حكينا،
+
+748
+01:16:00,270 --> 01:16:06,890
+الفك كبير، Giant Gonads، الـ Macro-orchidism،
+
+749
+01:16:06,890 --> 01:16:13,250
+يعني الـ testicles كبار، فهنا CGG،
+
+750
+01:16:13,250 --> 01:16:18,850
+Myotonia، الـ Cataract، Tope، يعني الـ Tope،
+
+751
+01:16:18,850 --> 01:16:24,500
+أظن ذكرتها الآن، اللي هي قطعة الشعر المستعار، اللي
+
+752
+01:16:24,500 --> 01:16:31,840
+بيصير عنده صلع، أو مستحيل منه مثل أبيه، بيجيب ذات،
+
+753
+01:16:31,840 --> 01:16:36,720
+الـ ذرية، مرات بيخطئوها، وقنادة الـ atrophy الـ
+
+754
+01:16:36,720 --> 01:16:40,900
+Huntington Disease، الـ Caudate Nucleus، عيب الـ
+
+755
+01:16:40,900 --> 01:16:48,930
+brain، ما فيها Acetylcholine ولا GABA، اللي هو
+
+756
+01:16:48,930 --> 01:16:59,070
+الـ Neurotransmitters، فكوديت Acetylcholine GABA، CAG،
+
+757
+01:16:59,070 --> 01:17:10,290
+وهي Cataract و Top و Gonadal Atrophy، CTG، وهيك يعني،
+
+758
+01:17:10,290 --> 01:17:12,930
+أنا
+
+759
+01:17:16,650 --> 01:17:22,290
+إحنا يوم الأربعاء ممكن نكمل، ماشي، أنا أساسًا عندي
+
+760
+01:17:22,290 --> 01:17:28,070
+تدريس ثاني، وبضطر أترككم هلّأ، ماشي، إذا حد عنده
+
+761
+01:17:28,070 --> 01:17:35,470
+أسئلة، يحط على group medical genetics، وإن شاء الله
+
+762
+01:17:35,470 --> 01:17:39,990
+يوم الأربعاء بنكمل، ماشي، الله يوفقكم
+
+763
+01:17:43,570 --> 01:17:46,470
+تمام يا دكتور، يعطيك العافية، أهلاً وسهلاً، يلا
+
+764
+01:17:46,470 --> 01:17:48,210
+السلام عليكم، السلام عليكم
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/uzpVhimo_X4_postprocess.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/uzpVhimo_X4_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..d8c49305fd6a2d41d45f079937e9d56e51fe7229
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/uzpVhimo_X4_postprocess.srt
@@ -0,0 +1,3056 @@
+1
+00:00:00,490 --> 00:00:06,230
+يعني إحنا الآن مطلوب من الطلاب إنهم يحلوا الأسئلة
+
+2
+00:00:06,230 --> 00:00:11,510
+اللي في المراجع الموجودة الـ USMLE وغيرها وغيرها
+
+3
+00:00:11,510 --> 00:00:23,620
+وبالتالي يعني يكون إذا في شيء صعبنقشه وراح نبدأ
+
+4
+00:00:23,620 --> 00:00:31,920
+ناخذ يعني سؤال فيه أحدكم بعتليها إنه مش فاهم أو
+
+5
+00:00:31,920 --> 00:00:38,340
+كان فيه صعوبة فبحاول
+
+6
+00:00:38,340 --> 00:00:42,920
+إن الأشياء اللي يعني شعرت إنه يمكن ماشددتش عليها
+
+7
+00:00:42,920 --> 00:00:49,930
+واضحكتها بالنسبة للمحاضرةنتكلم عنها ونشوف كيف
+
+8
+00:00:49,930 --> 00:00:59,090
+الموضوع وكيف بيجي يعني النقطة الأولى فيه اللي هو
+
+9
+00:00:59,090 --> 00:01:02,390
+موضوع الـLinkage Equilibrium وLinkage
+
+10
+00:01:02,390 --> 00:01:09,510
+Desequilibrium تواتر الإتزان وعدم الإتزان في
+
+11
+00:01:09,510 --> 00:01:20,540
+الترابطأحنا هنا السؤال يقول إنه درجة قرب موقعين
+
+12
+00:01:20,540 --> 00:01:28,320
+two loci for two genes مثلًا، أنا المثال اللي
+
+13
+00:01:28,320 --> 00:01:35,600
+دائمًا بضربه اللي هو الـHLA-A بعيد عن الـB بس
+
+14
+00:01:35,600 --> 00:01:42,800
+الـHLA-C قريب جدًا عن الـBحكيت هذا الكلام، دخل حتى
+
+15
+00:01:42,800 --> 00:01:48,600
+سريرياً إنه إحنا لما نعمل HLA-Typing لما نقرر
+
+16
+00:01:48,600 --> 00:01:55,640
+عمليات نقل الأعضاء وما نقل الأعضاء وكذا نفحص على
+
+17
+00:01:55,640 --> 00:02:01,520
+الـA وعلى الـB الـC لأنه مربوط مع الـB حتى ما
+
+18
+00:02:01,520 --> 00:02:07,040
+بنحتاج نفحص عليه فالفكرة تبعتها، اللي هي إنه بنقول
+
+19
+00:02:07,040 --> 00:02:14,000
+فيه Linked disequilibriumبسبب الترابط لأنه قريبات
+
+20
+00:02:14,000 --> 00:02:20,940
+على بعض إذا كان الـ B شكل معين الـ C بكون شكل محدد
+
+21
+00:02:20,940 --> 00:02:26,200
+كمان يعني في ارتباط زيادة فالـ
+
+22
+00:02:26,830 --> 00:02:30,510
+المثال اللي حاطينه بالـ Figure اللي بفرجيكم إياه
+
+23
+00:02:30,510 --> 00:02:36,470
+وإذا بحط Share Screen دقيقة
+
+24
+00:02:36,470 --> 00:02:46,050
+إذا بحط Share Screen اللي هو هذا المثال خلينا
+
+25
+00:02:46,050 --> 00:02:51,730
+هيك نقرأ الأرقام هذه في
+
+26
+00:02:51,730 --> 00:02:57,370
+الحالة الأولى نفترض إكتراضًاإنه أنا عندي Two Loci
+
+27
+00:02:57,370 --> 00:03:00,590
+واندي
+
+28
+00:03:00,590 --> 00:03:08,190
+Two Alleles يعني في كل الـGene في كل محل فيه
+
+29
+00:03:08,190 --> 00:03:15,110
+نسختين أو نوعين مختلفين من الـ… يعني مثلًا أنا
+
+30
+00:03:15,110 --> 00:03:20,590
+بتكلم عن الـABO System والـRh System هذولة Two
+
+31
+00:03:20,590 --> 00:03:27,980
+Loci واحد في الـABOبكون يا «A» يا «B» يا «O» والـ
+
+32
+00:03:27,980 --> 00:03:32,500
+«RH» يا بكون Positive أو Negative الـ Capital «D»
+
+33
+00:03:32,500 --> 00:03:36,540
+أو الـ Small «D»، «A» في الـ «N» بعضًا فإذا أنا
+
+34
+00:03:36,540 --> 00:03:44,160
+جيت مثلًا في الـ Locus «A» كان عندي مثلًا نفترض
+
+35
+00:03:44,160 --> 00:03:47,120
+الـ «A» الـ Capital والـ «A» الـ Small أنا عارف
+
+36
+00:03:47,120 --> 00:03:56,500
+إنهم 0.5 إلى 2.0هدولة بيعطونا الـ الـ الـ الـ
+
+37
+00:03:56,500 --> 00:04:06,080
+frequencies تبع الأليل اللي أنا عارفه ماشي وبعدين
+
+38
+00:04:06,080 --> 00:04:15,160
+اللقس التاني point oneالـ capital S والـ small s
+
+39
+00:04:15,160 --> 00:04:22,940
+هو point nine يعني هنا السائد عشرة بالنية والمتنحي
+
+40
+00:04:22,940 --> 00:04:27,380
+تسعين بالنية فإذا
+
+41
+00:04:27,380 --> 00:04:34,960
+بلاقي النسب للإثنين هذولة لما أتي أتحسن نفس
+
+42
+00:04:34,960 --> 00:04:40,320
+الإنسان للـ two low psi وأشوف شو الأليل اللي موجود
+
+43
+00:04:40,320 --> 00:04:44,260
+عنده في كل الأماكناللي هم المكانين هنا اللي أنا
+
+44
+00:04:44,260 --> 00:04:49,420
+بفحص عليهم، الـTwo copies وبلاقي النسب بهذه
+
+45
+00:04:49,420 --> 00:04:57,180
+الطريقة معناته إنه هذولة الـTwo loci ما لهم أي
+
+46
+00:04:57,180 --> 00:05:04,980
+ترابط مافي بينهم دخل، لأن نسبهم نسب يعني هي
+
+47
+00:05:04,980 --> 00:05:10,860
+المتوقعة من الـGeneral populationمن المعرفة
+
+48
+00:05:10,860 --> 00:05:16,060
+السابقة عندي بالنسبة للنسبة للـ «الليل» هدولة
+
+49
+00:05:16,060 --> 00:05:22,100
+وdistribution تبعاتهم بالـ population لو أنا مثلا
+
+50
+00:05:22,100 --> 00:05:33,640
+تفقدت كتالة الـ «Okay» هذا 0.1% الـ «locus 2» الـ
+
+51
+00:05:33,640 --> 00:05:40,870
+«S» والـ «locus 2» الـ «small s»0.9، هذه 10% وهذه
+
+52
+00:05:40,870 --> 00:05:48,050
+90% فأنا عارف إنه الأصل هدولة نص بنص آجي ألاقي إن
+
+53
+00:05:48,050 --> 00:05:51,910
+اللي عندهم capital A و capital S مافيش ولا حد بهذا
+
+54
+00:05:51,910 --> 00:05:59,010
+الشكل يعني كل اللي عندهم capital S طلع عندهم small
+
+55
+00:05:59,010 --> 00:06:06,110
+a فإذن في اغتباط في الحالة هذه لأن هذه النسب مش
+
+56
+00:06:06,110 --> 00:06:12,950
+نتيجة ضربالمعروف والمعلوم من نسب الـ Alleles اللي
+
+57
+00:06:12,950 --> 00:06:19,150
+موجودة في كل شيء فلما أشوف أنا بهذا الشكل وهنا
+
+58
+00:06:19,150 --> 00:06:24,970
+يعني المفروض هي 0.1 و هي 0.5، 0.5 يعني نصهم هيك و
+
+59
+00:06:24,970 --> 00:06:32,210
+نصهم هيك، هيك الأصل وهنا الأصل إذا 90% لازم يكون
+
+60
+00:06:32,210 --> 00:06:36,530
+نصهم هيك و نصهم هيك لما أشوف الاختلالات بهذا الشكل
+
+61
+00:06:36,530 --> 00:06:43,340
+معناته أنهفيه ارتباط وبالتالي مافيش توازن بالنسب
+
+62
+00:06:43,340 --> 00:06:48,000
+تبعاتهم نسميه linkage disequilibrium وهذه الظاهرة
+
+63
+00:06:48,000 --> 00:06:53,620
+ممكن تكون يعني مش قوية تماماً بهذا الشكل فيه ممكن
+
+64
+00:06:53,620 --> 00:06:57,620
+تكون شكل جزئي فبالتالي فيه بيصير linkage
+
+65
+00:06:57,620 --> 00:07:02,820
+disequilibrium partial بهذا الشكل يعني أرجو أنها
+
+66
+00:07:02,820 --> 00:07:07,190
+تكون واضحة وهذه النقطة الأولىبحب أؤكد عليها من
+
+67
+00:07:07,190 --> 00:07:16,410
+مراجعة الـ Quiz تبع المرة اللي كانت فيه أسئلة؟ ‏-
+
+68
+00:07:16,410 --> 00:07:18,950
+أعطيك العافية يا أخته ‏- الله يعفوك يا أستاذ
+
+69
+00:07:18,950 --> 00:07:23,330
+الكريم، أتفضل ‏- الأخته دلوقتي أسئلة أنت هرجيتها و
+
+70
+00:07:23,330 --> 00:07:26,810
+لا فيها قبل ‏- أنا بقى أشتغلت في سؤال على السؤال
+
+71
+00:07:26,810 --> 00:07:33,630
+اللي لسه شرحته ‏- هلأ تمام بس ‏- نعم ‏- هلأ تمام،
+
+72
+00:07:33,630 --> 00:07:38,630
+بس في حاجة تانيةاللي هي بس إذا حد عنده عنهاي
+
+73
+00:07:38,630 --> 00:07:42,890
+وبعدين فيه نقطة ثانية بس هيك بده أرجعها مرة ثانية
+
+74
+00:07:42,890 --> 00:07:47,390
+وبعدين فيه سؤال اللي واحد بعثني إياه على
+
+75
+00:07:47,390 --> 00:07:54,610
+الـWhatsApp بدخل عليه وبنشوفه وبعدين أي حد عنده أي
+
+76
+00:07:54,610 --> 00:08:00,270
+سؤال بنرجعه بنفرجيني من وين سؤاله وبنتكلم عنه فبس
+
+77
+00:08:00,270 --> 00:08:01,770
+في حد عنده سؤال هذا
+
+78
+00:08:09,980 --> 00:08:19,280
+طيب النقطة التانية حابب إنه تكون واضحة عندكم اللي
+
+79
+00:08:19,280 --> 00:08:24,940
+هي الفرق بين الـ Association و الـ Linkage يعني
+
+80
+00:08:24,940 --> 00:08:33,040
+المواضيع في هذا الجزء يعني هو فصل بعنوان «identify
+
+81
+00:08:33,040 --> 00:08:36,560
+the genetic basis of human disease» يعني كيف أنا
+
+82
+00:08:36,560 --> 00:08:47,300
+بديأدخل معرفتي بالـ… بالـGenetics واستخدام الـPCR
+
+83
+00:08:47,300 --> 00:08:53,480
+والتركيب الدقيق للجيل في المرض أو على الأمراض
+
+84
+00:08:53,480 --> 00:08:57,700
+فالنقطة
+
+85
+00:08:57,700 --> 00:09:02,520
+المهمة يعني الواحد يكون فاهمها اللي هي إنه أنا
+
+86
+00:09:02,520 --> 00:09:10,530
+مرات نتكلم مثلًاعلى إن الـ HLA-B27 is linked to
+
+87
+00:09:10,530 --> 00:09:16,550
+ankylosing spondylitis أو إذا فيه أندياشي بنسميه
+
+88
+00:09:16,550 --> 00:09:20,850
+association يعني فيه كلمة مرات بيستخدموا كلمة
+
+89
+00:09:20,850 --> 00:09:26,170
+linkage ومرات بيستخدموا association فالـ linkage
+
+90
+00:09:26,170 --> 00:09:32,050
+وهي يعني زي ما أنتم شايفين هنا عبارة عن مجموعة
+
+91
+00:09:32,050 --> 00:09:34,470
+نقاط ماشي
+
+92
+00:09:36,840 --> 00:09:43,520
+بتفرّك بين أمتى أستخدم كلمة أنا في ارتباط وفي
+
+93
+00:09:43,520 --> 00:09:49,120
+علاقة يعني هم الكلمات متشابهة بس بتكلم عن نقاط
+
+94
+00:09:49,120 --> 00:09:54,060
+شويه مختلفة فلما نقول linkage هو it follows the
+
+95
+00:09:54,060 --> 00:09:58,780
+inheritance of the disease trait and regions of
+
+96
+00:09:58,780 --> 00:10:03,120
+the genome from individual to individual in family
+
+97
+00:10:03,120 --> 00:10:13,090
+by degreesيعني لما أنا أجيب آلة فيها مثلا أشخاص
+
+98
+00:10:13,090 --> 00:10:18,530
+مصابين وفيها أشخاص طبيعيين، هاي اسمها linkage،
+
+99
+00:10:18,530 --> 00:10:23,950
+ماشي الـ Association اللي
+
+100
+00:10:23,950 --> 00:10:28,890
+هي لما نكون في test للـaltered frequency of
+
+101
+00:10:28,890 --> 00:10:32,470
+particular alleys or haplotypes in affected
+
+102
+00:10:32,470 --> 00:10:37,210
+individuals comparedwith controls in a population
+
+103
+00:10:37,210 --> 00:10:49,630
+يعني هنا ال .. ال .. يعني أنا بسوي إشي مشابه هو
+
+104
+00:10:49,630 --> 00:10:56,020
+أنا بجيب الناس عندهم المرض وفيه ناس سليمينوبشوف
+
+105
+00:10:56,020 --> 00:11:06,340
+الفرق بين نسب الخدوط الـ Certain Alleles أو
+
+106
+00:11:06,340 --> 00:11:09,820
+اللياشي اللي أنا بدرس عليه أو الـ Hablotype بطريقة
+
+107
+00:11:09,820 --> 00:11:15,780
+معينة بين مجموعة مصابة وبين الـGeneral Population
+
+108
+00:11:15,780 --> 00:11:19,800
+فهنا بنقولها Association، فديك بسميها Linkage
+
+109
+00:11:23,250 --> 00:11:27,770
+الـ «التواصل» يبحث عن مقاطع الجنوم اللي تتعامل مع
+
+110
+00:11:27,770 --> 00:11:30,270
+الـ Disease Alleles ويستخدم الـ Polymorphic
+
+111
+00:11:30,270 --> 00:11:36,270
+Variants فقط كطريقة لتواصل أي مقاطع تتعامل معها من
+
+112
+00:11:36,270 --> 00:11:43,830
+أي والد. وهي برضه، يعني، الـ «تواصل» يستخدم الـ
+
+113
+00:11:43,830 --> 00:11:46,610
+Hundred الـ «تواصل» يستخدم الـ Hundred لـ
+
+114
+00:11:46,610 --> 00:11:53,730
+Thousands of Polymorphic Markers عبر الجنومالتي
+
+115
+00:11:53,730 --> 00:12:00,190
+ليست مصممة لإيجار الـ Variant المسؤول عنها أو تسبب
+
+116
+00:12:00,190 --> 00:12:04,930
+في المرض يمكن أن يتمارك أين يمكن أن تجد الـ
+
+117
+00:12:04,930 --> 00:12:12,030
+Variant في عامة واحد أو عامة ميجابيزيات يعني لما
+
+118
+00:12:12,030 --> 00:12:18,840
+أقول أنا فيه Linkage أناما حتى يعني بحاول إن حد
+
+119
+00:12:18,840 --> 00:12:23,500
+تقنعه الـ Specific Variant إحنا حتى بيكون الـ
+
+120
+00:12:23,500 --> 00:12:34,940
+Linkage مع اللي هو قطعة كامة الـ Linkage relies on
+
+121
+00:12:34,940 --> 00:12:38,240
+recombination
+
+122
+00:12:38,240 --> 00:12:43,180
+events occurring in families during only a few
+
+123
+00:12:43,180 --> 00:12:45,970
+generations to allow«مقارنة مقارنة المقارنة
+
+124
+00:12:45,970 --> 00:12:49,690
+الجينية بين جنود المرض ومقارنة مقارنة مقارنة المرض
+
+125
+00:12:49,690 --> 00:12:50,910
+ومقارنة مقارنة المرض ومقارنة مقارنة المرض ومقارنة
+
+126
+00:12:50,910 --> 00:12:51,710
+مقارنة المرض ومقارنة المرض ومقارنة المرض ومقارنة
+
+127
+00:12:51,710 --> 00:12:55,470
+المرض ومقارنة المرض ومقارنة المرض ومقارنة المرض
+
+128
+00:12:55,470 --> 00:12:55,850
+ومقارنة المرض ومقارنة المرض ومقارنة المرض ومقارنة
+
+129
+00:12:55,850 --> 00:12:59,450
+ومقارنة المرض ومقارنة المرض ومقارنة المرض ومقارنة
+
+130
+00:12:59,450 --> 00:13:09,240
+المرض ومقارنةما بكون ما هو اسمه؟ ما بكون يعني ربطة
+
+131
+00:13:09,240 --> 00:13:14,720
+الـ Disease بالمرض مع الـ Gene هذا يعني إحنا لما
+
+132
+00:13:14,720 --> 00:13:23,300
+درسنا مثلا البيئة الـ S-Hemoglobin variation مقابل
+
+133
+00:13:23,300 --> 00:13:28,780
+الـ Sickle Cell Disease علينا نفهم ليش هذا الـ
+
+134
+00:13:28,780 --> 00:13:34,180
+Gene بدأأما لما أنا أعمل linkage يمكن اللي أنا
+
+135
+00:13:34,180 --> 00:13:41,300
+بربطه مع المرض هو مكان أنا يعني بيحتوي أو قريب من
+
+136
+00:13:41,300 --> 00:13:45,540
+الـGene تبع الـDisease بس أنا مابكون بعرف ليش أو
+
+137
+00:13:45,540 --> 00:13:50,060
+كيف هذا بيؤدي للمرض Require sampling of families
+
+138
+00:13:50,060 --> 00:13:53,540
+not just people affected with the disease I
+
+139
+00:13:53,540 --> 00:13:58,930
+بالـLinkageLoses power when disease has complex
+
+140
+00:13:58,930 --> 00:14:01,870
+inheritance and substantial lack of penetrance
+
+141
+00:14:01,870 --> 00:14:09,410
+more often أو
+
+142
+00:14:09,410 --> 00:14:14,510
+most often used to map disease-causing mutations
+
+143
+00:14:14,510 --> 00:14:17,930
+with strong enough effect to cause a Mendelian
+
+144
+00:14:17,930 --> 00:14:22,610
+inheritance pattern يعني الفكرة اللي بدي أوصلها
+
+145
+00:14:22,610 --> 00:14:31,500
+إنه عملية الـ linkageهي عملية يعني إن أنا أقول
+
+146
+00:14:31,500 --> 00:14:38,640
+نتيجة دراسة عائلة فيها ناس مصابين وناس مش مصابين
+
+147
+00:14:38,640 --> 00:14:46,540
+إن أنا قدرت أحدد علاقي مكاني في الـGenome في
+
+148
+00:14:46,540 --> 00:14:54,170
+ارتباط بينه وبين الـ… بينه وبين الـDiseaseوبكون
+
+149
+00:14:54,170 --> 00:15:00,850
+أنا اللي بستخدمه كـ Marker لمعرفة هذا الإرتباط ليس
+
+150
+00:15:00,850 --> 00:15:06,790
+بالضرورة مفسر أو شارع أو محدد لقالية تسبب المرض
+
+151
+00:15:06,790 --> 00:15:11,900
+يعني ممكن اللي أنا المنطقة اللي أربطها مع المرضهي
+
+152
+00:15:11,900 --> 00:15:20,780
+منطقة يعني مش يعني ما فيها إشي أنا بقدر كـ Disease
+
+153
+00:15:20,780 --> 00:15:27,000
+زي الـ S-Hemoglobin وSickle Cell Disease أقول هذا
+
+154
+00:15:27,000 --> 00:15:30,800
+هيك يسوي المرض هيك فهذه العلاقة اللي هي في قضية
+
+155
+00:15:30,800 --> 00:15:34,550
+الـ Language أما لما نحكي Associationالـ
+
+156
+00:15:34,550 --> 00:15:42,390
+Association هي دراسات على مستوى بتكون على مستوى
+
+157
+00:15:42,390 --> 00:15:45,770
+يعني مختلف اللي هو الـ frequency of the alien
+
+158
+00:15:45,770 --> 00:15:52,210
+between group of patients و group of controls في
+
+159
+00:15:52,210 --> 00:16:00,050
+ال population فهي يعني اللي كنت حابب نقطة تانية من
+
+160
+00:16:00,050 --> 00:16:00,570
+حقها
+
+161
+00:16:04,020 --> 00:16:13,100
+النقطة الأخيرة بدي أفرجيكم إياها ثواني عشان نسوي
+
+162
+00:16:13,100 --> 00:16:20,680
+share screen اللي هو سؤال بعضكم طرحه فيه إشي مش
+
+163
+00:16:20,680 --> 00:16:28,040
+فاهمي، مش فاهمي اللي هو خلّينا ننزل في السؤال لحد
+
+164
+00:16:28,040 --> 00:16:30,800
+ما نشوفه أظن بيجي بعدين
+
+165
+00:16:49,900 --> 00:16:54,740
+سؤال؟ كريم، عندك سؤال؟ حبيبما ألاقي السؤال، هلأ
+
+166
+00:16:54,740 --> 00:17:00,920
+أنا
+
+167
+00:17:00,920 --> 00:17:08,260
+شرح مش سؤال، هو يعني إيه؟ نعم، أه تفضل، احكي لأ،
+
+168
+00:17:08,260 --> 00:17:13,410
+في مواضيع من الـFirst Aidبس ممكن تشرحها، تريد
+
+169
+00:17:13,410 --> 00:17:22,490
+شرحها يعني؟ ماشي، طيب، بقدر تعمل share screen؟
+
+170
+00:17:22,490 --> 00:17:28,690
+بقدر أبعد لك صورة بسك؟ نعم أبعد الصورة في الـchat
+
+171
+00:17:28,690 --> 00:17:36,350
+وتنزلها من داك؟ إذا الـadmin بقدر يخليك تقدر تسوي
+
+172
+00:17:36,350 --> 00:17:42,800
+share screen مباشرة هذولة شفت الصور تبعت الـلما
+
+173
+00:17:42,800 --> 00:17:50,060
+الواحد يخطط تبعتلي إيش وبعدين أنا أبعته كده فبشوف
+
+174
+00:17:50,060 --> 00:18:00,740
+إنه ما بطلع كويس، يعني مش كويس طيب،
+
+175
+00:18:00,740 --> 00:18:08,090
+خلّينا نراجح هذا السؤالوبعدين من برضه الـUSMLE أو
+
+176
+00:18:08,090 --> 00:18:11,910
+CABLAN أو Genetics وكذا، من هنا الـReferences،
+
+177
+00:18:11,910 --> 00:18:19,010
+ماشي؟ يعني عشان تحلوا الأسئلة كويسة أول شيء، لازم
+
+178
+00:18:19,010 --> 00:18:27,470
+الواحد يقرأ السؤال كامل، يقرأ بفهم وشكل عامل، بقول
+
+179
+00:18:27,470 --> 00:18:31,990
+لك، young couple has undergone a successful in
+
+180
+00:18:31,990 --> 00:18:36,970
+-vitro fertilizationالأب يمتلئ بـ Cystic Fibrosis
+
+181
+00:18:36,970 --> 00:18:43,290
+والأم يمتلئ بأخت مع Cystic Fibrosis فرسمي لك الـ
+
+182
+00:18:43,290 --> 00:18:46,990
+Pedigree هنا يعني إذا الواحد إن شاء الله الـ
+
+183
+00:18:46,990 --> 00:18:55,270
+cursor واضح هذا الأب هو مصاب والأم عندها أخت مصابة
+
+184
+00:18:55,270 --> 00:19:03,310
+فهي الـ Pedigree بهذا الشكل هدولة سود يعني مصابين
+
+185
+00:19:04,760 --> 00:19:10,700
+والأثنين عندهم نفس الـ Mutation اللي هو Delta F508
+
+186
+00:19:10,700 --> 00:19:18,020
+يعني في الـ Position 508 فيه إشي اختلف ويعني اتغير
+
+187
+00:19:18,020 --> 00:19:23,940
+بهاي رمز الـ Mutation المجهول
+
+188
+00:19:23,940 --> 00:19:28,800
+هو الـ Mother's career status is unknown يعني هذه
+
+189
+00:19:28,800 --> 00:19:34,890
+الأم صراحة احنا حاليا مش عارفينهل هي career ولا
+
+190
+00:19:34,890 --> 00:19:39,890
+normal؟ بس phenotypically مظهريًا she looks normal
+
+191
+00:19:39,890 --> 00:19:44,790
+مش مصابة before making a decision to conceive the
+
+192
+00:19:44,790 --> 00:19:47,470
+couple underwent extensive genetic counseling
+
+193
+00:19:47,470 --> 00:19:51,450
+regarding the potential risks of having a child
+
+194
+00:19:51,450 --> 00:19:56,290
+with cystic fibrosis تفضلي بـ degree is diagrammed
+
+195
+00:19:56,290 --> 00:20:00,950
+below with the unborn child marked with the red R
+
+196
+00:20:02,580 --> 00:20:05,680
+What is the probability that the unborn child has
+
+197
+00:20:05,680 --> 00:20:12,960
+cystic fibrosis؟ شو احتمالية أنه اللي عليه هذا،
+
+198
+00:20:12,960 --> 00:20:16,300
+اللي حاطينه في هذا الشكل معين لأن لا هما يعرفين
+
+199
+00:20:16,300 --> 00:20:21,020
+لسه ولد ولا ابنه، ماشي، فحاطينها بهذا الشكل
+
+200
+00:20:21,020 --> 00:20:27,860
+وبالنسبة للمعلومات المعروفة اللي هي أن الأب مصاب
+
+201
+00:20:27,860 --> 00:20:38,050
+وأخت الأم مصابةفشو الـ Risk بالنسبة للجنين هذا؟
+
+202
+00:20:38,050 --> 00:20:45,710
+بالنسبة لما نكون، يعني بدكم اتفرجوا بين شغلتين في
+
+203
+00:20:45,710 --> 00:20:51,790
+حال هذا السؤال، بدك تتفرج بين لما تكون انت عارف،
+
+204
+00:20:51,790 --> 00:20:59,140
+لما تكون انت مش عارف، لما تكون عارفبتطبّق النسب
+
+205
+00:20:59,140 --> 00:21:05,000
+اللي أنت بتعرفها بالنسبة للنتيجة
+
+206
+00:21:05,000 --> 00:21:12,460
+لما تكون مش عارف حين تكملت السؤال Bank of Sen
+
+207
+00:21:12,460 --> 00:21:20,240
+بتقول بتطبّق الـConditional Probability يعني نظرية
+
+208
+00:21:20,240 --> 00:21:30,360
+الاحتمالات المشروبة ماشي؟ الآنلو احنا أخذنا مثل
+
+209
+00:21:30,360 --> 00:21:37,860
+هذا الـ B-degree لو أنا مش عارف شو الحاجة، ماشي من
+
+210
+00:21:37,860 --> 00:21:41,100
+ال .. يعني الـ Cystic Fibrosis معروف Extinct
+
+211
+00:21:41,100 --> 00:21:46,240
+Recesses أسف، Autosomal Recesses، ماشي؟ هو
+
+212
+00:21:46,240 --> 00:21:47,400
+Autosomal Recesses
+
+213
+00:21:50,340 --> 00:21:56,480
+بس لما نطلع الـ B-degree هذا النقطة الأولى إنه
+
+214
+00:21:56,480 --> 00:22:02,800
+ذكوره إناد مصابين فإذن هو مش X-linked الـ X-linked
+
+215
+00:22:02,800 --> 00:22:07,120
+يكون أكتر ذكور أو يعني بالذات بقى X-linked
+
+216
+00:22:07,120 --> 00:22:13,040
+Recessive بتكون ذكوره المصابين الشغل التاني إنه
+
+217
+00:22:13,040 --> 00:22:17,540
+الأباء لهدول المصابين Normal فبالتالي فهو
+
+218
+00:22:17,540 --> 00:22:23,170
+Recessiveوإثنين هم بيحملون الجيل فيعني اللي أنا
+
+219
+00:22:23,170 --> 00:22:29,090
+متأكد منه لآن so far إنه إذا اعتبرنا هذا الجيل
+
+220
+00:22:29,090 --> 00:22:34,210
+الأول اللي هدولة العين تاني هدولة الجيل الثاني
+
+221
+00:22:34,210 --> 00:22:40,870
+اللي هم العائلة اللي بتسأل والجيل الثالث هم ال ..
+
+222
+00:22:40,870 --> 00:22:46,450
+شو اسمه؟ ال .. ال .. الطفل اللي دي لم يولد لسه
+
+223
+00:22:46,450 --> 00:22:48,190
+ماشي؟
+
+224
+00:22:49,720 --> 00:22:55,580
+فإذا أخذنا أي عيلة من هدول العائلات من الجدود كل
+
+225
+00:22:55,580 --> 00:23:05,440
+جد من الجدين في العائلتين أكيد كارين لأنه وخلف إذا
+
+226
+00:23:05,440 --> 00:23:10,880
+اتفقنا إنه فعلا هو أبو الطفل هذا اللي ولد سواء
+
+227
+00:23:10,880 --> 00:23:18,580
+الأب أو الأم في الجيل التاني ماشيإذا الأب الجد هي
+
+228
+00:23:18,580 --> 00:23:22,540
+الجدود الأربعة لازم يكونوا career وهذا أنا أشمشي
+
+229
+00:23:22,540 --> 00:23:31,420
+متأكد منه الأب وأخت الزوجة أكيد مصعبين لأن عندهم
+
+230
+00:23:31,420 --> 00:23:38,380
+homozygous recessive الـ small فهذه أنا متأكد منهم
+
+231
+00:23:38,380 --> 00:23:45,880
+ماشي أسسبالنسبة ل... بما أنه أنا ما فحصت الأم للـ
+
+232
+00:23:45,880 --> 00:23:54,840
+Career State ماشي، بدي أعطي تقدير لقداش احتمالية
+
+233
+00:23:54,840 --> 00:24:04,020
+الجنين هذا يطلع Positive نسبة لقداش الأم، شو اسمه؟
+
+234
+00:24:04,020 --> 00:24:07,860
+احتمالية إنها تكون Career وقداش نسبة إنها تعطي
+
+235
+00:24:07,860 --> 00:24:16,370
+الجيل تبع الإصابة الأبأكيد راح يعطي 100% الـ «جين»
+
+236
+00:24:16,370 --> 00:24:21,210
+تبع الإصابة لأن هو 100% مصاب وبالتالي فإذا هو راح
+
+237
+00:24:21,210 --> 00:24:28,970
+يعطي 100% بالنسبة للأم في الحالة هذه بدنا نطبق ما
+
+238
+00:24:28,970 --> 00:24:32,470
+يسمى الـ Conditional Probability Conditional
+
+239
+00:24:32,470 --> 00:24:37,530
+Probability يعني الاحتماليات المشروطة وفي الحالة
+
+240
+00:24:37,530 --> 00:24:47,980
+هذه بنشوفها كالتاليةالـ بالنسبة للـ يعني شو اللي
+
+241
+00:24:47,980 --> 00:24:52,260
+أثر على الـ conditional probability غير إن الأشياء
+
+242
+00:24:52,260 --> 00:24:57,940
+أحنا بنعرفها أحنا بنعرف لما أثنين carriers
+
+243
+00:24:57,940 --> 00:25:03,880
+يتزاوجوا لـ autosomal recessors الاحتمالات واحد
+
+244
+00:25:03,880 --> 00:25:09,120
+واثنين وواحد من أربعة يعني هم أربع أرباع عادة
+
+245
+00:25:11,130 --> 00:25:16,050
+Capital A Capital A Capital A Small A Capital A
+
+246
+00:25:16,050 --> 00:25:20,230
+Small A Small A Small A مثلًا، أنا عندي أربعة عدد
+
+247
+00:25:20,230 --> 00:25:23,610
+فلمّا
+
+248
+00:25:23,610 --> 00:25:28,850
+نكون heterozygous وCareer
+
+249
+00:25:28,850 --> 00:25:36,970
+إحتماليات منفصلة عن ما يمكن نشوفه، يعني أنا مثلًا
+
+250
+00:25:37,260 --> 00:25:41,200
+لما عائلة يتزوجوا ويقول احتمال نص يجيبوا بلد
+
+251
+00:25:41,200 --> 00:25:47,340
+احتمال نص يجيبوا بنت ممكن ست مرات يطلع كله بنات
+
+252
+00:25:47,340 --> 00:25:52,220
+كله بنات كله بنات كله بنات اللي بعده فيه memory
+
+253
+00:25:52,220 --> 00:25:57,180
+loss يعني ما بتذكر النظام أنه الله أنا جيبت ست
+
+254
+00:25:57,180 --> 00:26:01,140
+ولاة ست بنات من قبل لازم أجيب هسا ولد مافي عندنا
+
+255
+00:26:01,140 --> 00:26:06,060
+أيش زيه يظل الاحتمالية نص بنص يطلع ولد وبنت عادي
+
+256
+00:26:06,060 --> 00:26:12,130
+منفصلةفهذه ظاهرة بتحدث صحيح بس في مرات إذا أنا
+
+257
+00:26:12,130 --> 00:26:13,190
+بعرف شو
+
+258
+00:26:13,190 --> 00:26:29,470
+الـ’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’�
+
+259
+00:26:34,620 --> 00:26:38,120
+فإذا عندها small a وsmall a أنا هايم أتأكد منها
+
+260
+00:26:38,120 --> 00:26:45,720
+الآن الأخت اللي هي أم الجنين اللي عليه السؤال
+
+261
+00:26:45,720 --> 00:26:48,900
+وخاله
+
+262
+00:26:48,900 --> 00:26:59,060
+خال الجنين هذا يعني أخه الأم هنا ماشي عليهم علامة
+
+263
+00:26:59,060 --> 00:27:07,070
+استفهام لأنه احنا يعني مش عارفهي أصل النسب رُبع
+
+264
+00:27:07,070 --> 00:27:13,430
+مُصاب نُص career ورُبع Healthy، Completely Healthy
+
+265
+00:27:13,430 --> 00:27:20,350
+فالفكرة في كلمة Conditional Probability إن أنا بما
+
+266
+00:27:20,350 --> 00:27:26,350
+أني عرفت إن هذا الإنسان مش مُصاب إذا مستحيل يكون
+
+267
+00:27:26,350 --> 00:27:30,710
+small a small a فبتصير عندي النسب مش من أربعة
+
+268
+00:27:30,710 --> 00:27:36,460
+بيصير عندي النسب من ثلاثةفبتصير تلتة مصابة تمامًا
+
+269
+00:27:36,460 --> 00:27:43,960
+وتلتين ماشية بيكونوا Carrier هيك النسب حسب
+
+270
+00:27:43,960 --> 00:27:50,440
+الاحتمالات لأنه هنا وهنا أكيد Carrier وهي مصابة
+
+271
+00:27:50,440 --> 00:27:54,960
+وهنا أكيد طبيعي مظهريًا because typically he is
+
+272
+00:27:54,960 --> 00:28:02,000
+okay أو she is okay فبالتالي لما نيجي ناخد أنه فيه
+
+273
+00:28:02,000 --> 00:28:10,290
+احتمالية تلتةإنه يكون Normal Completely Normal في
+
+274
+00:28:10,290 --> 00:28:16,690
+الحالة دي لما يتزوج هنا راح يكون التلت يعني أو
+
+275
+00:28:16,690 --> 00:28:27,370
+اللي بتضرب النسب ببعض بتكون هنا نص كارية ماشي؟
+
+276
+00:28:27,370 --> 00:28:32,530
+وبالنسبة لـ ال .. يعني ال .. ال ..
+
+277
+00:28:35,700 --> 00:28:45,140
+دقيقة، بالنسبة لما يكون التلتين،
+
+278
+00:28:45,140 --> 00:28:52,160
+يعني هنا إحنا هنا اللي لما تيجي تاقظ مثلا سؤال شو
+
+279
+00:28:52,160 --> 00:28:57,200
+احتمالية إنه الجنين هذا اللي هنا يطلع Completely
+
+280
+00:28:57,200 --> 00:29:02,040
+Normal، Zero لأنه أكيد راح يفتد واحد من الجيل
+
+281
+00:29:02,040 --> 00:29:07,070
+المضروب من أبوهفإذن هو مستحيل يطلع normal شو
+
+282
+00:29:07,070 --> 00:29:15,270
+احتمالية إنه يطلع career ماشي اللي لما يكون هذا
+
+283
+00:29:15,270 --> 00:29:19,150
+ثلث فشو
+
+284
+00:29:19,150 --> 00:29:24,830
+اسمه؟ راح يكون أكيد 100% career لو كان الأم
+
+285
+00:29:24,830 --> 00:29:30,830
+completely normal فهي ثلث ولمّا
+
+286
+00:29:30,830 --> 00:29:39,100
+يكون الأمعندها تلتين احتمال إنها تكون Career مرة
+
+287
+00:29:39,100 --> 00:29:46,700
+بتعطي، يعني هي تلتين احتمالية إنها تكون Career نص
+
+288
+00:29:46,700 --> 00:29:54,320
+الحالات تبع تلتين بتعطي الجين أو الأليل المصاب ففي
+
+289
+00:29:54,320 --> 00:29:59,540
+الحالة هذه، راح الطفل يكون مصاب ونص الاحتمالات راح
+
+290
+00:29:59,540 --> 00:30:04,090
+يكون تعطي النسقة الطبيعيةفهيطلع الطفل كاريا
+
+291
+00:30:04,090 --> 00:30:11,370
+فبالنسبة للـ Child هذا اللي أبوه مصاب وخالته مصابة
+
+292
+00:30:11,370 --> 00:30:17,970
+في عنده احتمالية ثلث انه يطلع مصاب واحتمالية ثلثين
+
+293
+00:30:17,970 --> 00:30:23,010
+انه يطلع كاريا واحتمالية صخر انه يطلع completely
+
+294
+00:30:23,010 --> 00:30:27,450
+normal فهدولة النسب تبعته فأول سؤال كان شو
+
+295
+00:30:27,450 --> 00:30:33,660
+احتمالية انه يطلع مصاب فهي ثلثهذه النقطة اللي بدنا
+
+296
+00:30:33,660 --> 00:30:38,000
+إياها أرجو أن تكون فاهم للذي سأل والذي سأل أن يكون
+
+297
+00:30:38,000 --> 00:30:47,420
+حاضر معانا في الشرح هذا في أسئلة؟
+
+298
+00:30:47,420 --> 00:30:57,120
+دكتور كريم عندك الشيء الأسئلة اللي بدك إياها من
+
+299
+00:30:57,120 --> 00:30:59,000
+أنه مارجع هذا ولا التاني؟
+
+300
+00:31:01,630 --> 00:31:07,090
+من كتاب First Aid ماعنديش يا First Aid و لا شو هو
+
+301
+00:31:07,090 --> 00:31:10,910
+من ال references اللي احنا حطناهم و لا من محل
+
+302
+00:31:10,910 --> 00:31:14,350
+تاني؟
+
+303
+00:31:14,350 --> 00:31:18,690
+لأ، هذا كتاب نفسه، مش مارجة أسئلة نفس اللي معايا
+
+304
+00:31:18,690 --> 00:31:26,850
+هذا؟ لأ، مارجة أسئلة ما هذا كله أسئلة في اللي هو
+
+305
+00:31:26,850 --> 00:31:32,480
+كتاب Kaplan You Are Sumely Step Oneاللي هو هيك
+
+306
+00:31:32,480 --> 00:31:39,780
+شكله، خلّيني، إيش اسمه؟ Resume shares؟ New shares؟
+
+307
+00:31:39,780 --> 00:31:48,120
+اللي هو هيك إن
+
+308
+00:31:48,120 --> 00:31:52,020
+شاء الله هيك واضح part two medical genetics هدول
+
+309
+00:31:52,020 --> 00:32:00,050
+اللي أعطونيها فيها بالـ بآخر الـ نعممنفع أعمل
+
+310
+00:32:00,050 --> 00:32:06,370
+share scheme من عند دكتور؟ أعمل
+
+311
+00:32:06,370 --> 00:32:12,350
+share scheme من عندك؟ والله الدكتور اللي معانا إذا
+
+312
+00:32:12,350 --> 00:32:16,570
+بتقدر تكليك تعمل share scheme أيوة عمللي عمللي بقى
+
+313
+00:32:16,570 --> 00:32:19,150
+منفع أعمل طيب يالا عمللي
+
+314
+00:32:45,840 --> 00:32:53,680
+طيب، أيوة، أه، أنا عندي واضح حسنا، تمام، في، في
+
+315
+00:32:53,680 --> 00:32:56,200
+أكم المرض هدولة مكررات في ال «first aid»، وشوية
+
+316
+00:32:56,200 --> 00:32:59,470
+حالهم بتفصيل يعني؟وحتى في أسئلة الـ Reward كان
+
+317
+00:32:59,470 --> 00:33:02,590
+بيسأل عنه وبيعطف تفاصيلهم كتير، فإذا ممكن تقيت
+
+318
+00:33:02,590 --> 00:33:09,050
+شرحهم هنا، بحسب ما هو شرحهم في الـ Test. «شو اللي
+
+319
+00:33:09,050 --> 00:33:13,070
+مش مفهوم؟»
+
+320
+00:33:13,070 --> 00:33:19,510
+«يعني إذا بدك تشترك في البردروتس، فيمشي عليه؟ إذا
+
+321
+00:33:19,510 --> 00:33:21,790
+بدك Cystic Fibrosis؟» «يوجد Cystic Fibrosis، فيه
+
+322
+00:33:21,790 --> 00:33:26,130
+تحتيق أمراض تانية»لأ، هذولة مش أمراض، هذولة
+
+323
+00:33:26,130 --> 00:33:49,750
+كيفية………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………�
+
+324
+00:33:50,570 --> 00:34:01,990
+اللي هو يعني مرض في منطقتنا مرض في ال .. ال ..
+
+325
+00:34:01,990 --> 00:34:06,910
+يعني في ال .. اللي هو بيعتبرونا البيض أحنا
+
+326
+00:34:06,910 --> 00:34:11,670
+كوكازيين كوكازيين أنا كوكازيين بالـGeletics تبع
+
+327
+00:34:11,670 --> 00:34:17,370
+العالم يعني لما أنت بتكتب أنت أحنا مش Hispanic ولا
+
+328
+00:34:18,730 --> 00:34:24,050
+African ولا Native American اللي هو «سكيمو» أو إشي
+
+329
+00:34:24,050 --> 00:34:28,410
+زي ذلك الآن
+
+330
+00:34:28,410 --> 00:34:36,210
+هذا مرض بسبب يعني أنا بتذكر أن في أستاذ إلي حكالي
+
+331
+00:34:36,210 --> 00:34:42,990
+عن أول حالة هو شخصها إنه الأم وحكيت أنا كلمة
+
+332
+00:34:42,990 --> 00:34:51,070
+قدامكمبتقولّه بلحس عرق الطفل تبعها اللي هو الجنين
+
+333
+00:34:51,070 --> 00:34:58,030
+أو الببو تبعها بتقولّه مالح كثير يا دكتور يعني حتى
+
+334
+00:34:58,030 --> 00:35:03,550
+مرات هيك لما الواحد ينشف العرق على جبينه ولا كده
+
+335
+00:35:03,550 --> 00:35:09,790
+بتحس إنه باقى ملح ففي مشكلة فيه لقينا بعدين إنه
+
+336
+00:35:09,790 --> 00:35:17,280
+الـ Sodium Chloride Pumpفي الـ… في الـMucous
+
+337
+00:35:17,280 --> 00:35:24,100
+Membranes فيها مشكلة، تعرف عليها؟ فإحنا الآن اللي
+
+338
+00:35:24,100 --> 00:35:29,180
+بنعرفه اللي هو إنه فيه Capital «C» و Capital «F» و
+
+339
+00:35:29,180 --> 00:35:33,580
+«T» و «R» اللي هو «Cystic Fibrosis Transporter
+
+340
+00:35:33,580 --> 00:35:41,360
+Gene» ماشي، هاي الإختصار تبعه «CFTR» طبعا «Gene»
+
+341
+00:35:41,360 --> 00:35:50,020
+بمعنى إنه هناالـ «جين» تبعه، ماشي؟ لما نكتب مثلاً
+
+342
+00:35:50,020 --> 00:35:55,660
+عن البروتين أو عن الـ RNA أو كده، ما بنحطش capital
+
+343
+00:35:55,660 --> 00:36:02,060
+letter، بنحط small letter، فاللي هو Etosomal
+
+344
+00:36:02,060 --> 00:36:06,580
+Recessive Defect بالـ Cystic Fibrosis Transporter
+
+345
+00:36:06,580 --> 00:36:12,760
+Gene موجود على كرموزوم 7، في Commonly Deletion بـ
+
+346
+00:36:13,010 --> 00:36:18,710
+الفنة الألانين بالـ Position 508 هذا الرموز اللي
+
+347
+00:36:18,710 --> 00:36:22,530
+حاطينها it is the most common lethal disease in
+
+348
+00:36:22,530 --> 00:36:29,390
+coccogysium population أكتر مرض قاتل في البيت
+
+349
+00:36:29,390 --> 00:36:37,770
+ورافقه ماشي هنا الآن ال pathophysiology يعني يمكن
+
+350
+00:36:37,770 --> 00:36:40,790
+يلقينا Cystic Fibrosis Transporter Gene
+
+351
+00:36:40,790 --> 00:36:46,900
+Associationأو الـ Linkage من الـ Linkage Studies
+
+352
+00:36:46,900 --> 00:36:51,740
+بس بعدين بدنا نفهم كيف بتسبب المرض فالـ
+
+353
+00:36:51,740 --> 00:36:59,200
+Pathophysiology إنه الـ ATP-gated chloride channel
+
+354
+00:36:59,200 --> 00:37:07,460
+اللي هي Sodium chloride channel بالإنرجي بدخله،
+
+355
+00:37:07,460 --> 00:37:12,840
+بطلّع Sodium وChloride ماشي في الـMucous Membranes
+
+356
+00:37:13,570 --> 00:37:18,070
+بيكون فيه defect وهذا ورح يأثر على الـ lungs والـ
+
+357
+00:37:18,070 --> 00:37:28,990
+GI tract ماشي، فيه الآن يعني النهاية أنه بيصير
+
+358
+00:37:28,990 --> 00:37:33,410
+علنا mutations، misfolded protein، protein
+
+359
+00:37:33,410 --> 00:37:40,110
+returned in the rough endoplasmic reticulumولم يتم
+
+360
+00:37:40,110 --> 00:37:44,090
+توصيله إلى الـ Cell Membrane بسبب أن الـ Chloride
+
+361
+00:37:44,090 --> 00:37:52,170
+بنزل والـ Secretion للـ Water بنزله وبظل الـ
+
+362
+00:37:52,170 --> 00:37:56,430
+Intracellular Chloride Result in compensatory
+
+363
+00:37:56,430 --> 00:38:02,290
+higher Sodium Reabsorption المهم، يعني في ميكانيزم
+
+364
+00:38:02,290 --> 00:38:08,370
+بخربط Sodium Chloride Pump في الـ Mucous Membrane
+
+365
+00:38:08,820 --> 00:38:13,380
+والـ Respiratory tract والـ GI tract حتى في الـ
+
+366
+00:38:13,380 --> 00:38:21,660
+Skin وحتى في الأشياء التانية فالآن كيف نشخصها؟ من
+
+367
+00:38:21,660 --> 00:38:27,700
+أوائل الـ Test اللي هي اللي هو اسمه الـ Chloride
+
+368
+00:38:27,700 --> 00:38:32,340
+يعني اللي بيسميه الـ Sweat Test الـ Sweat Test
+
+369
+00:38:32,340 --> 00:38:40,730
+يعني أبارعاً فحص بتجيبه الطفلبيحطوه بمنشطة وبعدين
+
+370
+00:38:40,730 --> 00:38:46,590
+بيحطوا عليها إشي تمنع تبخر الماء في حيث إنه يخلوه
+
+371
+00:38:46,590 --> 00:38:52,030
+يأرق ويأخذوا العرق تبعه ويفحصوه لمستوى الـ
+
+372
+00:38:52,030 --> 00:38:57,470
+Chloride والسوديوم والأشياء هذه فاللي هذا بيسموه
+
+373
+00:38:57,470 --> 00:39:03,730
+الـ Chloride Concentration in Bicarbene Induced
+
+374
+00:39:03,730 --> 00:39:09,070
+Swiss Test is Diagnosticمش كتير مفيد كتير كتير،
+
+375
+00:39:09,070 --> 00:39:13,810
+يعني في صعوبة إنك أنت تجمع كمية عرق من إنسان بيعرق
+
+376
+00:39:13,810 --> 00:39:21,090
+أو من طفل بيعرق وتجمعها وبعدين تتحص مظبوط يعني
+
+377
+00:39:21,090 --> 00:39:28,290
+اللي بتذكره رقم الـ60 إذا أعلى من 60 بالوحدات
+
+378
+00:39:28,290 --> 00:39:32,890
+تبعتها من ذاكرها لسه هذه بتكون ماشية مع التشكيز
+
+379
+00:39:32,890 --> 00:39:35,170
+هذا فالـ
+
+380
+00:39:36,660 --> 00:39:45,760
+الـ الـ يعني هو إنسان راح يكون عنده مثلا تكرار
+
+381
+00:39:45,760 --> 00:39:51,920
+التهابات بالصدر خراب في وظيفة البنكرياس ومالة
+
+382
+00:39:51,920 --> 00:39:59,260
+ذورشن وستاتورية اللي هي المظاهر تبعتهم ماشي طبعاً
+
+383
+00:39:59,260 --> 00:40:10,580
+ممكن أنا أبحث للجين تبعه ماشيوفي اللي هو الـ
+
+384
+00:40:10,580 --> 00:40:14,340
+«immunoreactive trypsinogen newborn screening
+
+385
+00:40:14,340 --> 00:40:21,740
+method» إذا في عندك منطقة فيهم كثير، ماشي، فهي كيف
+
+386
+00:40:21,740 --> 00:40:25,160
+بنسوي التشبيث، بس يعني غير إنك تدور على الـGen
+
+387
+00:40:25,160 --> 00:40:30,220
+mutation بتقدر تسوي له sweat test، هذا اللي بنقوله
+
+388
+00:40:30,670 --> 00:40:38,870
+وفيه «ترابسينوجين» level يعني بيكون «increased» مع
+
+389
+00:40:38,870 --> 00:40:45,770
+الكلوسيس والـ «هيبوكالينيا» هذولة لأنه يعني المرض
+
+390
+00:40:45,770 --> 00:40:50,330
+راح يخلي الـ «كلورايد» والـ «سوديوم» ينفرزوا برا
+
+391
+00:40:50,330 --> 00:40:58,980
+فالجسم بيحاول يسحبهم لجوا عشان يصير اتزانفلما يصير
+
+392
+00:40:58,980 --> 00:41:03,920
+هذه الشغل زي لما مثلًا واحد يأخذ Mineralocorticoid
+
+393
+00:41:03,920 --> 00:41:10,360
+أو كده نتيجة الموضوع هذا إنه عشان أنا أسحب في
+
+394
+00:41:10,360 --> 00:41:15,680
+الـ«كلاو» وفي الـ… يعني احنا هنا بنحكي عن الـSFTR
+
+395
+00:41:15,680 --> 00:41:22,640
+جين في الـMucous Membranes والـGI
+
+396
+00:41:22,640 --> 00:41:26,810
+tract يعني الـRespiratory tract والـGI tractعندما
+
+397
+00:41:26,810 --> 00:41:29,830
+كان تاني متدخّل كتير في هذه الأشياء الكيلة
+
+398
+00:41:29,830 --> 00:41:36,310
+والـSweat glands وكذا، في الكيلة إذا بدي أسحب الـ
+
+399
+00:41:36,310 --> 00:41:42,910
+Sodium والـ Cloride، بدي أرمي الـ Potassium والـ H
+
+400
+00:41:42,910 --> 00:41:48,570
+-Iron اللي هو الـ Hydrogen فلما أنا أخلص من، يعني
+
+401
+00:41:48,570 --> 00:41:52,650
+عشان أسحب الـ Sodium، بدي أخلص من الـ Potassium،
+
+402
+00:41:52,650 --> 00:41:58,230
+بيصير عندي Hypokalemiaولمّا أضطر عشان أسحب الـ
+
+403
+00:41:58,230 --> 00:42:03,330
+Sodium لدى أخلص من الـ Hydrogen راح يصير أنا بخلص
+
+404
+00:42:03,330 --> 00:42:08,030
+من الـ Acid يظل عندي Alkalosis فهدولة الـ
+
+405
+00:42:08,030 --> 00:42:13,390
+Diagnostic Test ناشي؟ وهي أنت بتشرح عليهم، الآن
+
+406
+00:42:13,390 --> 00:42:20,320
+الـ Complicationsاللي هم Recurrent Infections بالـ
+
+407
+00:42:20,320 --> 00:42:27,040
+Respiratory Tract شو اسمه؟ يعني هاي راح تسمي
+
+408
+00:42:27,040 --> 00:42:31,460
+تسوينا إشي بيسموه توسع القطبات تسمى Bronchiectasis
+
+409
+00:42:31,460 --> 00:42:38,620
+وفي عندي فشل الـGI tract بما فيها الـPancreatic
+
+410
+00:42:38,620 --> 00:42:43,380
+Insufficiency طبعاً الـPancreas غير إنه Endocrine
+
+411
+00:42:43,380 --> 00:42:51,670
+تشتغل Exocrineوبعطينا هرمونات، يعني إنزيمات وبيفرز
+
+412
+00:42:51,670 --> 00:42:56,030
+باي كاربو وبيعمل كده وبيعمل كده فبصير عندي
+
+413
+00:42:56,030 --> 00:43:00,570
+«malabsorption» اللي بيسموها «ستاتورية» يعني اللي
+
+414
+00:43:00,570 --> 00:43:06,870
+هو إنه بالذات
+
+415
+00:43:06,870 --> 00:43:12,450
+الدهون لا يتم انتصاصها بشكل طبيعي فبتظلها بالقناة
+
+416
+00:43:12,450 --> 00:43:20,220
+الهضمية وبتخرج مع الدراجةفبصير البراز حجم القطعة
+
+417
+00:43:20,220 --> 00:43:25,240
+تبعته كبيرة إذا عند الواحد حمام فرنجي تظلها طافي
+
+418
+00:43:25,240 --> 00:43:30,500
+فوق، تنزلش تحت فبالتالي، difficult to flush وبتصير
+
+419
+00:43:30,500 --> 00:43:37,160
+foul smelling وبتكون فيه مشكلة فهدولة من الأمراض
+
+420
+00:43:37,160 --> 00:43:42,520
+طبعاً معاها بصير الـFat Tulip الـVitamin
+
+421
+00:43:42,520 --> 00:43:48,250
+Deficiencyاللي هم A، D وE وK، وكلها بيصير عندنا
+
+422
+00:43:48,250 --> 00:43:53,630
+مشكلة، ماشي؟ الـB والـC هم الـWater-soluble
+
+423
+00:43:53,630 --> 00:43:58,990
+vitamins، فدول ما فيهم مشكلة، ما بتم انتصاصهم مع
+
+424
+00:43:58,990 --> 00:44:02,210
+انتصاص الفات، فالـPancreatic Insufficiency
+
+425
+00:44:02,210 --> 00:44:07,390
+والتتورية والـMalabsorption فهتخرب انتصاص الفات
+
+426
+00:44:07,390 --> 00:44:10,990
+الـSoluble Vitamins، فبيصير عندى deficiency لكل
+
+427
+00:44:10,990 --> 00:44:16,220
+أشياءوBiliary Cirrhosis وLiver Disease Meconium
+
+428
+00:44:16,220 --> 00:44:20,400
+Elias الميكونيوم
+
+429
+00:44:20,400 --> 00:44:29,460
+هو الـ Brass تبع الـ Newborn يعني
+
+430
+00:44:29,460 --> 00:44:34,620
+من كثر لأنه الملوحة زايدة في الـ Secretions وفي
+
+431
+00:44:34,620 --> 00:44:39,450
+الـ GI Tractsومش قادر الواحد ينظم أو الجهاز ينظم
+
+432
+00:44:39,450 --> 00:44:44,270
+نفسه الـ Brass في الـ Newborn بيصير يابس كتير
+
+433
+00:44:44,270 --> 00:44:49,790
+وبنتيجته أنه بيسبب نوع من شلل الأمعان في حيث أنه
+
+434
+00:44:49,790 --> 00:44:55,590
+بيبطل تمشي فبيصير الـ Meconium alias الـ Newborn
+
+435
+00:44:55,590 --> 00:44:59,870
+من الأشياء اللي شو اسمها كمان بتصير عندهم
+
+436
+00:44:59,870 --> 00:45:07,670
+Infertility وتكون Subfertility in womenماشي بيكون
+
+437
+00:45:07,670 --> 00:45:15,090
+نتيجة يعني defects في نتيجة الـGene هذا وفيه عندنا
+
+438
+00:45:15,090 --> 00:45:18,670
+nasal polyps و clubbing on the nails أدول
+
+439
+00:45:18,670 --> 00:45:23,630
+الـCommon فهو هنا الـTreatment symptomatic يعني
+
+440
+00:45:23,630 --> 00:45:32,470
+بنحط شو اسمه؟ طبعاً الـNail
+
+441
+00:45:32,470 --> 00:45:35,680
+clubbingاللي هي ظاهرة الـ clubbing على الـ fingers
+
+442
+00:45:35,680 --> 00:45:39,180
+جزء أهم أساس أساسها الـ recurrent infection
+
+443
+00:45:39,180 --> 00:45:42,540
+والبرونكياكتسس البرونكياكتسس with or without
+
+444
+00:45:42,540 --> 00:45:47,420
+cystic fibrosis راح تخلي فيه clubbing وبعدين أنا
+
+445
+00:45:47,420 --> 00:45:50,900
+بحاول أساعد المريضة بفعله chest physical therapy
+
+446
+00:45:50,900 --> 00:45:57,400
+بعطيه bronchodilator بحط عشان أدوب الـ mucus لأنه
+
+447
+00:45:57,400 --> 00:46:02,540
+thick و very thick بسموها الـDNAيعني عبارة عن
+
+448
+00:46:02,540 --> 00:46:07,820
+enzyme aerosolized يعني بيحطوه بالنفس عشان يعني
+
+449
+00:46:07,820 --> 00:46:11,820
+يذوب الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+450
+00:46:11,820 --> 00:46:12,160
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+451
+00:46:12,160 --> 00:46:13,360
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+452
+00:46:13,360 --> 00:46:14,220
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+453
+00:46:14,220 --> 00:46:15,000
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+454
+00:46:15,000 --> 00:46:17,020
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+455
+00:46:17,020 --> 00:46:19,200
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+456
+00:46:19,200 --> 00:46:23,720
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+457
+00:46:23,720 --> 00:46:28,300
+الـ
+
+458
+00:46:28,300 --> 00:46:35,120
+الـ الماشي، هذا المرض الأول، شو اللي بعده؟ إذا في
+
+459
+00:46:35,120 --> 00:46:39,140
+أسئلة، يعني هذا Cystic Fibrosis موجود في كتابكم،
+
+460
+00:46:39,140 --> 00:46:44,780
+موجود هنا، كده، ماشي، بقى وهذه اللي اسمها Extinct
+
+461
+00:46:44,780 --> 00:46:51,240
+Recessive Disorder، ماشي، آسف، اللي احنا دي Autism
+
+462
+00:46:51,240 --> 00:46:56,480
+Recessive اللي إيه Cystic Fibrosisهنا حاطين شو
+
+463
+00:46:56,480 --> 00:47:03,860
+اسمه Extinct Recesses ماشي بيه مرض الـ Duchenne
+
+464
+00:47:03,860 --> 00:47:13,880
+Dystrophy هذا نعم الـ Duchenne شو اسمه فيه عبارة
+
+465
+00:47:13,880 --> 00:47:23,530
+عن جيل مسئول عنالـ «بروتين» الـ «ديستروفين» هذا هو
+
+466
+00:47:23,530 --> 00:47:31,490
+بروتين موجود في الـ الـ «موسلز» عشان الـ «أكتين»
+
+467
+00:47:31,490 --> 00:47:35,770
+والـ «مايوسين» اللي هم البروتينات اللي بتعمل الـ
+
+468
+00:47:35,770 --> 00:47:41,970
+«موسلز» وبتخلّي الـ «موسلز» تشتغل، ماشي خربا، في
+
+469
+00:47:41,970 --> 00:47:44,330
+مشكلة، ماشي
+
+470
+00:47:45,940 --> 00:47:50,660
+فبالنهاية بيأثر على الـ Intracellular Cytoskeleton
+
+471
+00:47:50,660 --> 00:47:57,180
+اللي هو الـ Actin ناشي؟ وفيه له أكثر من شغل فالآن
+
+472
+00:47:57,180 --> 00:48:05,200
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+473
+00:48:05,200 --> 00:48:05,220
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+474
+00:48:05,220 --> 00:48:05,360
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+475
+00:48:05,360 --> 00:48:05,940
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+476
+00:48:05,940 --> 00:48:08,640
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+477
+00:48:08,640 --> 00:48:19,400
+الـ الـ الـ الـوهو مسئول عن الـ «دستروفين»، ماشي؟
+
+478
+00:48:19,400 --> 00:48:24,120
+وهذه حاطينة كتدوشين هو «deleted distrophin» يعني
+
+479
+00:48:24,120 --> 00:48:28,320
+الـ «دستروفين» اللي هو البروتين اللازم لوظيفة
+
+480
+00:48:28,320 --> 00:48:35,560
+العضلات مفقود وكون صار له «deletion»، ماشي؟ الآن
+
+481
+00:48:35,560 --> 00:48:41,620
+بالنسبة لمثل هيك مرض الـ
+
+482
+00:48:43,000 --> 00:48:51,260
+في عدة ضواحب النقطة الأولى ماشية بالأخير
+
+483
+00:48:51,260 --> 00:48:56,600
+هو فيه muscle weakness يعني الطفل ما يقعدش طبعاً
+
+484
+00:48:56,600 --> 00:49:02,600
+الدشين اللي هو النوعية الشديدة منه فيه issue اسمه
+
+485
+00:49:02,600 --> 00:49:11,220
+بكر muscular dystrophy البكر نفس الدشين بس الدشين
+
+486
+00:49:11,220 --> 00:49:20,190
+أشدوببين من الطفولة وبطولش البكر بيجي بعدين يعني
+
+487
+00:49:20,190 --> 00:49:26,090
+بيظهر مثلا يعني الدوشين مستحيل تقريبا يوصلوا فوق
+
+488
+00:49:26,090 --> 00:49:34,430
+الـ 12 ثانية يعني شو اسمه؟ راح يكونوا يعني يموتوا
+
+489
+00:49:34,430 --> 00:49:39,220
+بشكل مبكروأهم محل اللي بتخرب فيه العضلات الرياتين
+
+490
+00:49:39,220 --> 00:49:44,120
+أو العضلات التنفسية أو على الوقوف ولا الماشي ولا
+
+491
+00:49:44,120 --> 00:49:50,760
+كده فـ «دوشين» أشد وبيخلق .. بي .. بيموتوا بسرعة
+
+492
+00:49:50,760 --> 00:50:01,380
+فيه والد يعني الفكر أخر وبيبدأ متأخر وبيطوله أكتر
+
+493
+00:50:01,380 --> 00:50:11,330
+ماشيالآن الـ Duchene نتيجة خراب الـ الـ الـ الـ
+
+494
+00:50:11,330 --> 00:50:16,230
+muscle protein الـ الـ motor development بتصير
+
+495
+00:50:16,230 --> 00:50:22,590
+ضعيفة يعني بتطلع بـ طبعاً جزء منه بنقول pseudo
+
+496
+00:50:22,590 --> 00:50:28,670
+hypertrophy يعني إيش؟ اللي هي يعني hypertrophy
+
+497
+00:50:28,670 --> 00:50:35,200
+تدخم بس هاي تدخم كابتيعني إذا إنسان طبيعي بيروح
+
+498
+00:50:35,200 --> 00:50:41,080
+بيجيب عضلات وثبات بيصير يحرك في عضلاته ويمرّن نفسه
+
+499
+00:50:41,080 --> 00:50:47,380
+ويقويها العضلات بتتضخم وتكبر تستجيب للتمرين فهي
+
+500
+00:50:47,380 --> 00:50:52,780
+true hypertrophy ماشي، بتكون عضلات الواحد هي قوية
+
+501
+00:50:52,780 --> 00:50:58,760
+أما اللي عنده الدوشين بيكون شكل العضلات الكبير بس
+
+502
+00:50:58,760 --> 00:51:03,060
+هي عضلات ضعيفة عشان هي بتسميها pseudo hypertrophy
+
+503
+00:51:03,550 --> 00:51:12,830
+فأنا في صورة عندكم بالكتاب اللي هو «تومسون» بيحطين
+
+504
+00:51:12,830 --> 00:51:18,990
+هيك بطة واحد وهيك كبيرة بس ضعيفة، ناشي؟ فهي بدنا
+
+505
+00:51:18,990 --> 00:51:23,470
+نقولها «Calve pseudo-hypertensive» الـ«إش» التاني
+
+506
+00:51:23,470 --> 00:51:27,930
+لديه شيء Characteristic اللي هو «Goers sign» اللي
+
+507
+00:51:27,930 --> 00:51:34,530
+هو حاطينكم إياها هنا، إنه الطفلأو الإنسان هذا لما
+
+508
+00:51:34,530 --> 00:51:42,930
+ترفعها شويه لما بده يوقف ماشي لما بده يوقف كأنه
+
+509
+00:51:42,930 --> 00:51:50,050
+بتسلك على حاله يعني بكون نايم على ظهره بده يحاول
+
+510
+00:51:50,050 --> 00:51:56,970
+يوقف فشو بعمل؟ بكون نايم على ظهره بالأول بقلب على
+
+511
+00:51:56,970 --> 00:52:02,930
+بطنه برفع كفاب الأول هيكوبعدين بيحاول يحمل حاله
+
+512
+00:52:02,930 --> 00:52:08,450
+بهذا الشكل وبعدين بيستخدم إيديه إنه يرتكز على
+
+513
+00:52:08,450 --> 00:52:14,950
+تخدتيه وجريه عشان يكوّم نفسه، ماشي؟ فهي اسمها
+
+514
+00:52:14,950 --> 00:52:20,150
+Gower sign اللي هو ال patient uses upper extremity
+
+515
+00:52:20,150 --> 00:52:25,430
+to help stand up يعني بتسلق على نفسه، بهذه الطريقة
+
+516
+00:52:25,430 --> 00:52:31,340
+لما تشوف طفل أو إنسان بيوقف بهذه الطريقةهذه مع الـ
+
+517
+00:52:31,340 --> 00:52:34,960
+Muscular Disabilities مع الـ Muscle Weakness مع
+
+518
+00:52:34,960 --> 00:52:42,220
+الـ Dad «دوشين» كطفل صغير، ماشي؟ فهذه اللي اسمها
+
+519
+00:52:42,220 --> 00:52:49,120
+«جوار الصين»، ماشي الحال؟ الآن نتيجة المشاكل في
+
+520
+00:52:49,120 --> 00:52:56,270
+الـ Muscle Fibers و الـ Muscle Proteins و كدهالـ
+
+521
+00:52:56,270 --> 00:52:59,870
+«CPK» الإنزايم الخاص بـ «كرياتين» مثل «كاينيل» أو
+
+522
+00:52:59,870 --> 00:53:05,470
+«فوتبو كاينيل» بيصير مرتفع وهي كان من المظاهر إنه
+
+523
+00:53:05,470 --> 00:53:12,050
+فيه مشكلة بالنسبة للـ «مصر»،
+
+524
+00:53:12,050 --> 00:53:18,630
+ماشي؟ فالآن احنا، خلّيني نذكر شغل، هذا X-linked
+
+525
+00:53:18,630 --> 00:53:23,730
+recessive يعني الأولاد اللي بنصابه، وبروح بدور على
+
+526
+00:53:23,730 --> 00:53:29,240
+أخاهماشي باسأله عن خالق آي اللي بده تكون والـ
+
+527
+00:53:29,240 --> 00:53:36,120
+females بكونوا career ماشي ال females والله في
+
+528
+00:53:36,120 --> 00:53:44,040
+واحدة عندها طلعت دوشين وهي Turner ماشي ماعنداش غير
+
+529
+00:53:44,040 --> 00:53:49,060
+copy واحدة من ال X ممكن، ممكن تكون عندها بس بتكون
+
+530
+00:53:49,060 --> 00:53:57,560
+unusual ننزل تحت ال baker نفس ال دوشينبس بتبدأ بـ
+
+531
+00:53:57,560 --> 00:54:05,740
+يعني هي نوع أخر وبتبدأ شو اسمه؟ في مرحلة يعني
+
+532
+00:54:05,740 --> 00:54:12,260
+متأخر عنه يعني الـ «دوشين» عادة بتوفر قولنا على
+
+533
+00:54:12,260 --> 00:54:18,780
+عمر الـ 12 يعني يدوبك يدخل يكون adolescent يعني
+
+534
+00:54:18,780 --> 00:54:23,600
+مرحلة الـ Blue فالبكر نوع أخر بس من نفس المشكلة
+
+535
+00:54:24,150 --> 00:54:30,930
+وبتكون يعني الـ onset متأخر عن البكر عن الدشين
+
+536
+00:54:30,930 --> 00:54:41,950
+والمريد بعيش أكتر ماشي فيه إيش اسمه Myotonia أحنا
+
+537
+00:54:41,950 --> 00:54:50,010
+هنا يعني هدف ال course بالذات عن الـ Genetics مش
+
+538
+00:54:50,010 --> 00:54:55,460
+عن الـ Diseasesماشي، يعني هم الواحد اللي بعرف عن
+
+539
+00:54:55,460 --> 00:54:58,960
+الـ Disease بيفهم الـ Genetics أكتر صحيح وإن
+
+540
+00:54:58,960 --> 00:55:03,660
+الواحد اللي اتقرب إلها صحيح بس أنا بتوقع أنه يعني
+
+541
+00:55:03,660 --> 00:55:10,360
+خلّينا يعني نتذكر علاقة ال manifestation والعراب
+
+542
+00:55:10,360 --> 00:55:18,020
+والظواهر مع ال genes وشو دخلها البكر أخف نشيل أقوى
+
+543
+00:55:18,020 --> 00:55:29,620
+وأشد، ماشي والـ Mayotoniaهو عبارة عن حالة اللي
+
+544
+00:55:29,620 --> 00:55:38,040
+هي تعريفها إذا الواحد بتذكر الـ… الـPhysiology تبع
+
+545
+00:55:38,040 --> 00:55:43,560
+الـMuscle وكيف الـMuscle بيصير فيها Contracture
+
+546
+00:55:43,560 --> 00:55:54,390
+الـMuscle، بدك تتذكر إنه الـMuscleالـ ATP والإنرجي
+
+547
+00:55:54,390 --> 00:56:01,870
+هو في الـ phase of release يعني أنت العضلات بتلاقي
+
+548
+00:56:01,870 --> 00:56:08,550
+مثلا هذا أكتين وهذا مايوسين خيوط بتلاقيها لما بدها
+
+549
+00:56:08,550 --> 00:56:16,170
+العضلة مثلا تنقبض بفسلا عن بعض وبعدين بقصر و بقرب
+
+550
+00:56:16,170 --> 00:56:19,970
+أكتر على بعض مثلا يعني بيكون هيك بالأول بعاد عن
+
+551
+00:56:19,970 --> 00:56:24,880
+بعضالـ Energy اللي بدك إياها عشان يفكن عن بعض
+
+552
+00:56:24,880 --> 00:56:28,800
+وتقربهم بعدين على بعض يمسكوا بشكل أقوى، هيك بيصير
+
+553
+00:56:28,800 --> 00:56:35,560
+الـ Contraction فالـ Myotonia هي إن الـ muscle ما
+
+554
+00:56:35,560 --> 00:56:42,140
+فيها relaxation بتلاقي ال muscle spastic يعني شده،
+
+555
+00:56:42,140 --> 00:56:47,020
+ماشي؟ فمثلا هنا حتى هحطيه لكيا اللي هي تعريف الـ
+
+556
+00:56:47,020 --> 00:56:53,060
+Myotoniaيعني بتيجي على بني آدم بتسلم عليه بس يشد
+
+557
+00:56:53,060 --> 00:57:02,860
+إيده، بيقدرش يفلطها، هيك بتسلطيه، ماشي، شو اسمهم؟
+
+558
+00:57:02,860 --> 00:57:08,580
+بعدين هنا هو Autosomal Dominant أنا مش عارف ليش
+
+559
+00:57:08,580 --> 00:57:17,190
+حاطينا هنا اللي هو الميتونالثلاثة هدولة مسكولر
+
+560
+00:57:17,190 --> 00:57:22,910
+بيزيدي بس بكر ودوشين X-linked recesses الـ
+
+561
+00:57:22,910 --> 00:57:26,990
+«ميوتونيا» أتذكر autosomal dominance الأصل ما
+
+562
+00:57:26,990 --> 00:57:30,690
+حدفعاش معاهم بس كلهم إشي بالـ muscle يعني هاي اللي
+
+563
+00:57:30,690 --> 00:57:34,370
+بدتك تتذكرها «توبيم» والله ما نتذكر «Early balding
+
+564
+00:57:34,370 --> 00:57:41,850
+in men» يعني إذا الواحد بصلّعت سرعة يعني أو صلّعت
+
+565
+00:57:41,850 --> 00:57:48,550
+مبكروكان هذا الـ Atrophy الحالة الجانب الثالث CTG
+
+566
+00:57:48,550 --> 00:57:56,290
+وهدولة Tri-Nucleotide Repeat Expansion ماشي يمكن
+
+567
+00:57:56,290 --> 00:58:00,970
+دوشين Muscular PK بعرفش لإيش يعني إيش قريب يمكن
+
+568
+00:58:00,970 --> 00:58:08,750
+للدوشين ماشي
+
+569
+00:58:10,650 --> 00:58:17,630
+فيعني هاي الشيء بتتذكره CTG هو الـ Tri-Nucleotide
+
+570
+00:58:17,630 --> 00:58:22,350
+Repeat وفي نفس الوقت أنه الـ Myotonia بيصير معاهم
+
+571
+00:58:22,350 --> 00:58:28,350
+كترة يعني بيصير عندهم مي زرقة، مي بيضة وبيصير
+
+572
+00:58:28,350 --> 00:58:34,230
+عندهم سلع وبيصير أنه الـ Gonads بيصير هم أثروا
+
+573
+00:58:34,230 --> 00:58:40,680
+فيهم بشكل مبكر فدول كلهم مع الـMyotoniaفدولة «my
+
+574
+00:58:40,680 --> 00:58:45,820
+tone is type 1» يعني في أكتر من نوع أو كده آه،
+
+575
+00:58:45,820 --> 00:58:52,340
+كمّل، هذا «ملتون»،
+
+576
+00:58:52,340 --> 00:59:04,980
+آه، طيب، فالـ يعني، شوف، بالنسبة لأغراض انتحاركم
+
+577
+00:59:04,980 --> 00:59:12,090
+معايكثير من هذه الأمراض أنا كنت حابب أنه يعني إذا
+
+578
+00:59:12,090 --> 00:59:18,770
+أنتم ماعندكم خلفية خلفية سريرية يعني أمراض إن
+
+579
+00:59:18,770 --> 00:59:26,110
+عندكم هيكي معلومات طبية أكبر يعني مافيه داعة دخول
+
+580
+00:59:26,110 --> 00:59:29,810
+كتير في تفاصيل شو هذا المرض وشو هذا المرض وكذا
+
+581
+00:59:29,810 --> 00:59:35,600
+وهيكي بساللي مطلوب إنك انت تتذكره أو تحفظه قدر ما
+
+582
+00:59:35,600 --> 00:59:40,700
+بتكون تعرفه أكتر، بتكون أكتر اللي هي الـGenetics
+
+583
+00:59:40,700 --> 00:59:47,780
+تبعاتك، ماشي؟ يعني مثلا الـFragile X-Syndrome أو
+
+584
+00:59:47,780 --> 00:59:54,080
+Red Syndrome اللي هو الـRed هسة أنا والله ماكنت
+
+585
+00:59:54,080 --> 00:59:58,300
+عارفه من قبل أو مش بتذكره Sporadic disorder seen
+
+586
+00:59:58,300 --> 01:00:03,050
+almost exclusively in girlsالجماهير يموتون في
+
+587
+01:00:03,050 --> 01:00:07,330
+مدينة نيوترو قريبًا بعد الحفر أكثر الحالات هذه
+
+588
+01:00:07,330 --> 01:00:13,190
+ملحوظة من ميكبتين ميكبتين ميكبتين ميكبتين ميكبتين
+
+589
+01:00:13,190 --> 01:00:13,530
+ميكبتين ميكبتين ميكبتين ميكبتين ميكبتين ميكبتين
+
+590
+01:00:13,530 --> 01:00:14,330
+ميكبتين ميكبتين ميكبتين ميكبتين ميكبتين ميكبتين
+
+591
+01:00:14,330 --> 01:00:15,310
+ميكبتين ميكبتين ميكبتين ميكبتين ميكبتين ميكبتين
+
+592
+01:00:15,310 --> 01:00:22,430
+ميكبتين ميكبتين ميكبتين ميكبتين ميكبتين ميكبتين
+
+593
+01:00:22,430 --> 01:00:27,500
+ميكبتين ميكالـMotor، الـVerbal، الـCognitive
+
+594
+01:00:27,500 --> 01:00:30,280
+Abilities، الـAtaxia، الـSeizure، الـGrowth
+
+595
+01:00:30,280 --> 01:00:34,840
+Ferries، الـStereotype، الـHand Wiggling،
+
+596
+01:00:34,840 --> 01:00:38,060
+الـWringing،
+
+597
+01:00:38,060 --> 01:00:42,900
+الـRegression، ممكن يا دكتور، Fragile X Syndrome،
+
+598
+01:00:42,900 --> 01:00:46,480
+هذا يمكن كان مكرر كتير في الأسئلة، يعني إذا بتكشفش
+
+599
+01:00:46,480 --> 01:00:49,980
+رحلية الـSyndrome، فFragile X، فFragile كان ممكن
+
+600
+01:00:49,980 --> 01:00:57,030
+تكشف الـWorld، خلينا ناخدهم،اسمها regression ماشي
+
+601
+01:00:57,030 --> 01:01:03,610
+اللي هو يعني التراجع يعني احنا بالأطفال أنا مش
+
+602
+01:01:03,610 --> 01:01:08,130
+طبيب أطفال بس بالأطفال الـ milestones تبعات الطفل
+
+603
+01:01:08,130 --> 01:01:15,030
+يعني أمتى عند الولادة أو أول الولادة و بعدها على
+
+604
+01:01:15,030 --> 01:01:18,810
+أي مدة و هاي الـ 70 أطفال مسؤولين عنها و لازم يحرك
+
+605
+01:01:18,810 --> 01:01:23,640
+أمتى الطفل بيقدر يقلب على بطنهولو ما تحطه على ظهره
+
+606
+01:01:23,640 --> 01:01:27,700
+أمتى بيقدر يجلد؟ أمتى بيقدر يجول؟ أمتى بيقدر يوقف؟
+
+607
+01:01:27,700 --> 01:01:32,220
+أمتى بيقدر يمشي؟ هاي كلها motor بنسميها milestone
+
+608
+01:01:32,220 --> 01:01:36,980
+يعني مهارات
+
+609
+01:01:36,980 --> 01:01:46,700
+حركية إلها يعني تواريخ معينة لازم بشكل طبيعي الطفل
+
+610
+01:01:46,700 --> 01:01:52,060
+يكتسبها مهارات يكتسبها جديدةفلمّا يكون مثلًا طفل
+
+611
+01:01:52,060 --> 01:01:59,080
+كان يقدر يقلب، بطل، كان يقدر يقعد، بطل يقدر يقعد،
+
+612
+01:01:59,080 --> 01:02:03,200
+كان يقدر يوقف، بطل يقدر يوقف، بطل يقدر يمشي، كان
+
+613
+01:02:03,200 --> 01:02:08,920
+يقدر يركض، كان كذا، هذه كلها Motor Skills فإذا
+
+614
+01:02:08,920 --> 01:02:13,220
+فيها تراجع، نسميه Regression في نفس الوقت
+
+615
+01:02:13,220 --> 01:02:19,140
+الـVerbal يعني بدأ يحكي بابا، ماما بالأول لازم
+
+616
+01:02:19,630 --> 01:02:24,010
+وبعدين بابا وبعدين مثلا نسير يتكلم باقيت الكلمات
+
+617
+01:02:24,010 --> 01:02:29,950
+والـ Cognitive الـ Ataxia الـ Coordination تبع
+
+618
+01:02:29,950 --> 01:02:38,610
+الحركات لو حدوث تشنجات أو Growth Failure أو أنه
+
+619
+01:02:38,610 --> 01:02:42,650
+مثلا بيحرك يديه بشكل معين، هذه كلها اسمها Red
+
+620
+01:02:42,650 --> 01:02:48,570
+Syndrome أهم شي فيها أنه بيصير Regression وشو
+
+621
+01:02:48,570 --> 01:02:55,930
+اسمه؟هي اللي احنا بدنا ياه إنه X-chromosome linked
+
+622
+01:02:55,930 --> 01:03:07,250
+وشكلها dominant ماشي الـ الـ الـ males die ال
+
+623
+01:03:07,250 --> 01:03:13,490
+females بيصير عندهم المشاكل ده ماشي فهدول أي شيء
+
+624
+01:03:13,490 --> 01:03:19,480
+مهم ال X ال fragile X syndromeاللي هو X-linked
+
+625
+01:03:19,480 --> 01:03:21,880
+dominant inheritance شكله زي اللي في الـ Rett
+
+626
+01:03:21,880 --> 01:03:30,000
+Syndrome الـ Trilucotide repeat in FM-fragile أو
+
+627
+01:03:30,000 --> 01:03:35,080
+FMR1-Gene، Hypermethylation تؤدي لـ Decreased
+
+628
+01:03:35,080 --> 01:03:38,580
+aggression، most common cause of inherited
+
+629
+01:03:38,580 --> 01:03:41,080
+intellectual disability، and second most common
+
+630
+01:03:41,080 --> 01:03:44,940
+cause of genetically associated mental deficiency
+
+631
+01:03:44,940 --> 01:03:46,420
+after Down syndrome
+
+632
+01:03:50,810 --> 01:03:57,730
+الـ «high X-linked dominant inheritance» هيك اللي
+
+633
+01:03:57,730 --> 01:04:07,270
+يعني بالأخير بيقدّي لشو اسمه؟ بيقدّي لـ «mental
+
+634
+01:04:07,270 --> 01:04:14,070
+deficiency» وبيعتبروه ثاني لـ «down syndrome» الـ
+
+635
+01:04:14,070 --> 01:04:21,080
+«findings»Post-Provertial Macro-Orchidism لـ Large
+
+636
+01:04:21,080 --> 01:04:28,860
+Testicles Long Face with a Large Jaw بيصير تضخم أو
+
+637
+01:04:28,860 --> 01:04:35,120
+الفك السفلي والقلوي الكبار Large Reverted Ears
+
+638
+01:04:35,120 --> 01:04:41,760
+Autism Microvalve Prolapse يعني
+
+639
+01:04:41,760 --> 01:04:49,070
+هو سبب للتخلف العقليوهيك المظهر تنين كبار فكت كبير
+
+640
+01:04:49,070 --> 01:04:58,770
+يعني تشوّات معينة بتكون موجودة وفي FMR1 جيل بيصير
+
+641
+01:04:58,770 --> 01:05:04,270
+عنده زيادة أو insertion لتلاتيات من الـNucleotides
+
+642
+01:05:04,270 --> 01:05:09,340
+ماشي؟ وبيصير hypermetilationاللي هو جزء من الـ
+
+643
+01:05:09,340 --> 01:05:12,560
+Epigenetic Control وبعد إلى Dictated Expression
+
+644
+01:05:12,560 --> 01:05:23,020
+يعني هاي المظاهر تبعته، ماشي أنا أظن يعني تفاصيلها
+
+645
+01:05:23,020 --> 01:05:30,840
+مش مقتنع إنه راح تفيد يعني لغير قضية الدخول
+
+646
+01:05:30,840 --> 01:05:36,800
+إمتحانات الـUSA ملي والـ يعني في، إذا الواحد بيفكر
+
+647
+01:05:36,800 --> 01:05:43,050
+يسويهايعني تفاصيل الأمراض هذه مطلوبة من المتخصص
+
+648
+01:05:43,050 --> 01:05:51,070
+يعني بس كطلاب أنتم مسئولين، شو كمان يا دكتور كريم؟
+
+649
+01:05:51,070 --> 01:05:56,390
+أحسن لو أنه في أسئلة يعني هدول هيأخر موضوع الـ
+
+650
+01:05:56,390 --> 01:06:00,350
+Huntington's disease شو هميت الـ Huntington's
+
+651
+01:06:00,350 --> 01:06:07,110
+disease؟ مرض سيء، ماشي، الـ
+
+652
+01:06:08,580 --> 01:06:13,060
+بيدّي الـ… يعني إليها اسم مثلًا بيسموها
+
+653
+01:06:13,060 --> 01:06:17,560
+«Huntington Chorea» أو «Huntington Disease»
+
+654
+01:06:17,560 --> 01:06:24,460
+«Chorea» هي عبارة عن حالة حصبية، ماشي، إذا بدي
+
+655
+01:06:24,460 --> 01:06:32,740
+أجيجولة إنه بتلاقي الواحد كل شوي دا بتحرك من بلا
+
+656
+01:06:32,740 --> 01:06:41,660
+إرادة وبكون يعني مش متحكم بعضلاتهويعني المشكلة فيه
+
+657
+01:06:41,660 --> 01:06:50,060
+إنه يعني بالأخير لا بيقدر واحد يأكل أو يعني يتحرك
+
+658
+01:06:50,060 --> 01:06:55,980
+بشكل طبيعي بنتج عنه إنه الـ «شو اسمه؟» بنتج عنه
+
+659
+01:06:55,980 --> 01:07:04,340
+إنه ال .. بنتج عنه إنه بيتوفوا بشكل مبكر نال نسبية
+
+660
+01:07:04,340 --> 01:07:06,880
+بس العيب تبعه إنه
+
+661
+01:07:09,360 --> 01:07:13,560
+البداية متأخرة، أنا على سن الأربعين أو على سن
+
+662
+01:07:13,560 --> 01:07:20,060
+الخمس، أنا أقل شيء 35 لـ40، فالعيب تبعه في هذه
+
+663
+01:07:20,060 --> 01:07:25,520
+القضية أنه على سن الأربعين غالبية الناس يُعتدوا on
+
+664
+01:07:25,520 --> 01:07:29,200
+the dominant، يعني ذكور أو إنات، ويكونوا اتجوزوا
+
+665
+01:07:29,200 --> 01:07:37,830
+وخلفوا وصار عنده ناس وكذا، ماشي؟فالحالة هذه
+
+666
+01:07:37,830 --> 01:07:45,510
+المشكلة بتكون أن الولاد والبنات ده شخص مصاب بهذا
+
+667
+01:07:45,510 --> 01:07:50,730
+الاشي وفي الحالة هذه بتلاقي بيجي يركض على الأطباء
+
+668
+01:07:50,730 --> 01:07:54,870
+«شو أعمل؟» «شو أسوي؟» في ناس في دول كتير بتلاقي
+
+669
+01:07:54,870 --> 01:08:00,810
+بنتحر ولا كده ولا هيك يعني فبتلاقي فيه مشكلة
+
+670
+01:08:03,650 --> 01:08:09,090
+يعني هي إفعيلها جانب أخلاقي إنه أنت شخص بتلاقيه
+
+671
+01:08:09,090 --> 01:08:13,950
+كبير بالعمر أربعين سنة ويقولك لأن أبوه مات عمره
+
+672
+01:08:13,950 --> 01:08:20,990
+ستين أو خمس وخمسين بموت صعب بالشلل بطريقة عاشية
+
+673
+01:08:20,990 --> 01:08:26,470
+وفيها مشكلة فبيقولك طب أنا شو احتمالية أن أكون
+
+674
+01:08:26,470 --> 01:08:33,610
+حامل المرض هذا؟ فهذا المرض اتزاما الـ dominantيعني
+
+675
+01:08:33,610 --> 01:08:39,690
+فيه مشكلة وبعدين إذا هو اتزوج يمكن يأخر زواجه يمكن
+
+676
+01:08:39,690 --> 01:08:45,450
+مارضعش يخلف لأنه خايف 50% يعطي الطفل الـChance أو
+
+677
+01:08:45,450 --> 01:08:58,890
+يروح يتحصل، يعمل IVF ويسوي نوع من الدراسة لقضية هل
+
+678
+01:08:58,890 --> 01:09:06,430
+هو الجنين مصاب ولا مش مصابفكل هذه بتكون موجودة هو
+
+679
+01:09:06,430 --> 01:09:13,550
+أنا صراحة حاطينكم يعني الـ Huntington's disease
+
+680
+01:09:13,550 --> 01:09:19,190
+الـ Myotonic Dystrophy وحاطيني Fredrick's Ataxia
+
+681
+01:09:19,190 --> 01:09:23,830
+كمان رجال X-Syndrome اتكلمنا عنه برضه mental
+
+682
+01:09:23,830 --> 01:09:31,100
+deficiency ويعني بقدر تخلف عقلالـ Friedreich's
+
+683
+01:09:31,100 --> 01:09:36,940
+ataxia يعني أنا بتذكرها في الطب بتعطي مشاكل في
+
+684
+01:09:36,940 --> 01:09:45,520
+القلب بتعطي شو اسمه؟ إذا بتاخد بالعصاب Upper motor
+
+685
+01:09:45,520 --> 01:09:50,200
+neuron legion الـ Friedreich's ataxia من أسباب الـ
+
+686
+01:09:50,200 --> 01:09:54,860
+BOTH إنه في نفس الإنسان Upper motor و Lower motor
+
+687
+01:09:54,860 --> 01:10:00,380
+neuron legion في أي ناحيةالـ Upper Motor Neuron
+
+688
+01:10:00,380 --> 01:10:04,400
+Legion بيعمل Spasticity بيعمل Exaggerated Reflexes
+
+689
+01:10:04,400 --> 01:10:10,480
+بيعمل كده فالـ و العكس الـ Lower Motor Neuron
+
+690
+01:10:10,480 --> 01:10:17,060
+Legion بتعمل Flaccidity يعني هيك بتلاقي العضلات
+
+691
+01:10:17,060 --> 01:10:22,980
+رخوة زي إذا طفل أو إنسان عنده مثلا البوليو اللي هو
+
+692
+01:10:22,980 --> 01:10:31,390
+شلل الأفطار وبتلاقي Absent Reflexes وكدهأنا بتوقع،
+
+693
+01:10:31,390 --> 01:10:37,930
+بتوقع إنه الـ… الـ… هنا دولة، التلت أو أربع امراض
+
+694
+01:10:37,930 --> 01:10:42,390
+حاطين إنه الـTrinucleotide Repeat Expansion
+
+695
+01:10:42,390 --> 01:10:51,270
+Disease يعني فيه protein أو جين أو إشي بيصير الـ…
+
+696
+01:10:51,270 --> 01:10:58,330
+شو اسمه؟ بيصير تلافيات من الـ… من الـNucleotides
+
+697
+01:10:59,130 --> 01:11:05,290
+بيصير لهم insertion زيادة فالمرات
+
+698
+01:11:05,290 --> 01:11:10,930
+بتخرب وظيفة البروتين إنه كذا amino acid أو كذا إشي
+
+699
+01:11:10,930 --> 01:11:17,030
+بالحق مش المفروض يكون محتوى، بس يعني مرتبط بكمية
+
+700
+01:11:17,030 --> 01:11:21,430
+يعني مش زي الـsickle cell إنه one nucleotide اللي
+
+701
+01:11:21,430 --> 01:11:28,090
+متغير سبب مرض، فالـrepeats هو أنا حاطينها بالـN
+
+702
+01:11:29,560 --> 01:11:35,520
+رابطين كل مرض بـ «كاج»
+
+703
+01:11:35,520 --> 01:11:39,300
+«كج» «كج» «كج» «كج» «كج» «كج» «كج» «كج» «كج» «كج»
+
+704
+01:11:39,300 --> 01:11:41,460
+«كج» «كج» «كج» «كج» «كج» «كج» «كج» «كج» «كج» «كج»
+
+705
+01:11:41,460 --> 01:11:44,640
+«كج» «كج» «كج» «كج» «كج» «كج» «كج» «كج» «كج» «كج»
+
+706
+01:11:44,640 --> 01:11:44,800
+«كج» «كج» «كج» «كج» «كج» «كج» «كج» «كج» «كج» «كج»
+
+707
+01:11:44,800 --> 01:11:46,820
+«كج» «كج» «كج» «كج» «كج» «كج» «كج» «كج» «كج» «كج»
+
+708
+01:11:46,820 --> 01:11:55,940
+«كج» «كج» «كج
+
+709
+01:11:57,060 --> 01:12:01,580
+يعني أنا من الأشياء اللي شُفتها وقلتلكم ان تتبعوا
+
+710
+01:12:01,580 --> 01:12:07,840
+عليها اللي هي الـ Stop-on Codon تبع الـ… تبع الـ…
+
+711
+01:12:07,840 --> 01:12:12,940
+الـTriplets دولة تبع الـTri-Nucleotides لما نتيجي
+
+712
+01:12:12,940 --> 01:12:18,000
+تلاتة اللي بيقشروا على إنه أي Stop فيه ثلاث
+
+713
+01:12:18,000 --> 01:12:25,380
+Repeats من الـ64 possible triplets،
+
+714
+01:12:25,380 --> 01:12:33,180
+ماشي؟فهذولا الـ… يعني حتى هنا بيحاولوا يساعدوكم
+
+715
+01:12:33,180 --> 01:12:39,000
+إنه يعطيكم الـMnemonics تبعتها كيف تربطها وهي في
+
+716
+01:12:39,000 --> 01:12:43,400
+الطب ضرورية يعني
+
+717
+01:12:43,400 --> 01:12:47,140
+الـTry
+
+718
+01:12:47,140 --> 01:12:52,960
+nucleotide أنا بحاول أشوف «Try hunting for my
+
+719
+01:12:52,960 --> 01:13:01,620
+fragile cage-free egg»X يعني هاي كلمات يعني هاي
+
+720
+01:13:01,620 --> 01:13:07,400
+أسلوب إذا بتلاقوا إشي وحاولوا تحفظوها بتفيد، بتفيد
+
+721
+01:13:07,400 --> 01:13:13,100
+يعني أنا مثلا كنت بالـAnatomy شاطر الـAnatomy كنا
+
+722
+01:13:13,100 --> 01:13:16,220
+الله يرضى عليهم أساتفنا أو بكتير من المصريين
+
+723
+01:13:16,220 --> 01:13:22,240
+يحاولوا يحفظونا الأشياء تحتهم فكان مثلا شو أسماء
+
+724
+01:13:22,240 --> 01:13:29,800
+عظام الـAnkle والله صعببس كان فيه دكتور الله يرفع
+
+725
+01:13:29,800 --> 01:13:34,460
+عليه ويرحمه الآن يقول تفيدة كلت كشري ناشف و تلت
+
+726
+01:13:34,460 --> 01:13:42,400
+كتاكيد تاليوس، كالكانيوس، كونيفورم، نيوبفورم، مش
+
+727
+01:13:42,400 --> 01:13:45,900
+عارف إيش بس هي يعني الـ… الـ… الـ… الـMnemonic
+
+728
+01:13:45,900 --> 01:13:52,720
+تبعها طريقة الحفظ هذه مفيدة وكويسة فاللي حاطينه
+
+729
+01:13:52,720 --> 01:14:01,260
+لكميا عليه أحمر، كويسTri-Nucleotide Hunting for My
+
+730
+01:14:01,260 --> 01:14:12,520
+Fragile Cage-Free Eggs My Tonic
+
+731
+01:14:12,520 --> 01:14:21,100
+Hunting يعني الـ Tri-Nucleotide Hunting اللي هي
+
+732
+01:14:21,100 --> 01:14:28,720
+Hunting في كوريا أو Diseaseاللي هي Myotonia cage
+
+733
+01:14:28,720 --> 01:14:35,540
+-free اللي هي fragile X و fragile يمكن Fredericks
+
+734
+01:14:35,540 --> 01:14:43,360
+ماشي أو fragile لتنتين free اللي هي fragile أو
+
+735
+01:14:43,360 --> 01:14:52,200
+free مش عارف free Fredericks يعني فهذه جزء يعني
+
+736
+01:14:53,910 --> 01:14:58,090
+للإبتحانات الـ USMLE كويس الواحد ينتبه لها إن
+
+737
+01:14:58,090 --> 01:15:01,410
+هدولة أربع أمراض الـ Tri-Nucleotide Repeat
+
+738
+01:15:01,410 --> 01:15:07,130
+Expansion Diseases وهدولة الأمثلة تبعتها، كويسة،
+
+739
+01:15:07,130 --> 01:15:10,990
+يعني تستفيدوا منها إن شاء الله إذا الواحد بيقدر
+
+740
+01:15:10,990 --> 01:15:16,550
+يحفظ الـ الـ شو هي ال repeat تبعت كل مرض يمكن إن
+
+741
+01:15:16,550 --> 01:15:20,810
+شاء الله بتجيب نسب عالة و أحسن وشكلها مركزين عليه
+
+742
+01:15:22,890 --> 01:15:28,250
+الملاحظ الـ «هانتنغتون» والـ «مايتونيا» أتزامة
+
+743
+01:15:28,250 --> 01:15:32,390
+dominant رجال الـ X-syndrome X-linked dominant X
+
+744
+01:15:32,390 --> 01:15:36,330
+-linked dominant الـ «فريدريكس أتاكسيا» أتزامة
+
+745
+01:15:36,330 --> 01:15:45,730
+recessive يعني AI مهمة بدي أحفظ لخياهم شو الـ
+
+746
+01:15:45,730 --> 01:15:49,870
+trionucleotides «فريدريكس أتاكسيا» attacks الـgate
+
+747
+01:15:51,270 --> 01:16:00,270
+فـ «GAA» حاططها ماشي «Fragile Eggs» «Shin» حكينا
+
+748
+01:16:00,270 --> 01:16:06,890
+الفك كبير «Giant Gonads» الـ «Macro-Orchidism»
+
+749
+01:16:06,890 --> 01:16:13,250
+يعني التستيكلز كبار فهنا «CGG»
+
+750
+01:16:13,250 --> 01:16:18,850
+«Myotonia» الـ «Cataract» «Tope» يعني الـ «Tope»
+
+751
+01:16:18,850 --> 01:16:24,500
+أظن دكرتها الآناللي هي قطعة الشعر المستعار اللي
+
+752
+01:16:24,500 --> 01:16:31,840
+يبقى عنده صلع أو مستحيل منه مثل أبيه بيجيب ذات
+
+753
+01:16:31,840 --> 01:16:36,720
+زلام مرات بيخطوها وقنادة الـ Atrophy الـ
+
+754
+01:16:36,720 --> 01:16:40,900
+Huntington Disease الـ Caudate Nucleus عيب الـ
+
+755
+01:16:40,900 --> 01:16:48,930
+Brain مافيش فيها Acetylcholine ولا الجابااللي هو
+
+756
+01:16:48,930 --> 01:16:59,070
+الـ Neurotransmitters فكوديت أسيتالكولين جابها CAG
+
+757
+01:16:59,070 --> 01:17:10,290
+وهي Cataract وTop T وGonadal Atrophy CTG وهيك يعني
+
+758
+01:17:10,290 --> 01:17:12,930
+أنا
+
+759
+01:17:16,650 --> 01:17:22,290
+أحنا يوم الأربعة ممكن نكمل، ماشي أنا أسا عندى
+
+760
+01:17:22,290 --> 01:17:28,070
+تدريس تانى وبضطر أترككم هلأ، ماشي إذا حد عنده
+
+761
+01:17:28,070 --> 01:17:35,470
+أسئلة يحط على group medical genetics وإن شاء الله
+
+762
+01:17:35,470 --> 01:17:39,990
+يوم الأربعة بنكمل، ماشي الله يوفقكم
+
+763
+01:17:43,570 --> 01:17:46,470
+تمام يا دكتور، يعطيك العافية أهلا وسهلا، يالا
+
+764
+01:17:46,470 --> 01:17:48,210
+السلام عليكم السلام عليكم
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/vL1zB0LyhmE.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/vL1zB0LyhmE.srt
new file mode 100644
index 0000000000000000000000000000000000000000..4ce6bf171e5c4b615f64ddcf3498b51f3e570b8c
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/vL1zB0LyhmE.srt
@@ -0,0 +1,2927 @@
+1
+00:00:00,000 --> 00:00:05,780
+في عرض السؤال يُذكر
+
+2
+00:00:05,780 --> 00:00:11,960
+إنه مش فاهم الصورة هذه، نعود
+
+3
+00:00:11,960 --> 00:00:17,360
+مرة ثانية بالكاميرا، دكتور، إذا في إمكانية، أستعمل
+
+4
+00:00:17,360 --> 00:00:26,360
+مشاركة الشاشة برضه؟ آه، آه، طيب خلّيني بس أتأكد،
+
+5
+00:00:26,360 --> 00:00:28,200
+سأعمل
+
+6
+00:00:33,660 --> 00:00:50,060
+خلّيني أيضًا أتأكد من إرسال هذا الفيديو -719،
+
+7
+00:00:50,060 --> 00:00:56,180
+ليس الصورة هذه -
+
+8
+00:01:06,510 --> 00:01:13,290
+ماشي، حسّا، شو اللي بنقدر نقوله عن القصة بالنسبة
+
+9
+00:01:13,290 --> 00:01:21,890
+لسؤال زميلكم؟ بيسألني،
+
+10
+00:01:21,890 --> 00:01:25,150
+ممكن لو سمحت، ما عرفت الـGenotype لكل من الزوج
+
+11
+00:01:25,150 --> 00:01:30,150
+والزوجة في هذه الحالة بالنسبة
+
+12
+00:01:30,150 --> 00:01:39,790
+لسؤال هذا، يعني الأهم أن الواحد يكون
+
+13
+00:01:39,790 --> 00:01:43,950
+قادر يقرأ الـPedigree هذه، أو الشجرة العائلية هذه
+
+14
+00:01:43,950 --> 00:01:48,650
+بطريقة سليمة، يعني زوج وزوجة، أنا زوج وزوجة، يعني
+
+15
+00:01:48,650 --> 00:01:59,250
+فيه بالـ اللي هم الجيل الأول، الأب
+
+16
+00:01:59,250 --> 00:02:04,290
+والأم، اللي هم أبو الـ يعني أبو الجدود، اللي هم اللي
+
+17
+00:02:04,290 --> 00:02:09,350
+فوق، زي ما أنتَ حطيت هنا، لما نحط أزرق معناته مصاب
+
+18
+00:02:09,350 --> 00:02:15,150
+لما نعبيها جوا، لما نحط عليها شرطة معناته متوفاة
+
+19
+00:02:15,150 --> 00:02:23,830
+فأبو الجد وأم
+
+20
+00:02:23,830 --> 00:02:29,760
+الجد أو الجدود، الاثنين هم متوفّيان، اللي فيه حطّيه نقطة
+
+21
+00:02:29,760 --> 00:02:34,720
+بالنصف، هذه معناته "حامل" "Carrier"، اللي عليه إشارة
+
+22
+00:02:34,720 --> 00:02:44,880
+كذا "مشطوب"، يعني متوفاة، فهنا بتتكلم عن عائلة من
+
+23
+00:02:44,880 --> 00:02:48,260
+Extended
+
+24
+00:02:48,260 --> 00:02:55,080
+Family، الجيل الرابع عندهم ثمانية عشر شخص، مرقمينهم من واحد
+
+25
+00:02:55,080 --> 00:03:00,020
+لحد ثمانية عشر، واضح، الجيل الثالث ثلاثة عشر أشخاص، الجيل
+
+26
+00:03:00,020 --> 00:03:07,700
+الثاني أربعة أشخاص، الجيل الثاني فيه ذكور وفيه إناث
+
+27
+00:03:07,700 --> 00:03:11,160
+اثنين منهم
+
+28
+00:03:11,160 --> 00:03:16,300
+مصابين، آسف، الجيل الثاني فيه ذكور وفيه إناث
+
+29
+00:03:16,300 --> 00:03:23,270
+اثنين منهم حاملين للمرض، Carriers، لأنه صحيح إحنا بنعرف
+
+30
+00:03:23,270 --> 00:03:29,450
+أن الأم، الجدّة، أو الجيل الأول، الأنثى كانت مصابة، بس
+
+31
+00:03:29,450 --> 00:03:37,490
+الإصابات بالنسبة لـ .. بالنسبة من الأحفاد، وأبناء
+
+32
+00:03:37,490 --> 00:03:42,250
+الأحفاد، فيه بالذكور وفيه بالإناث، يعني هذه الاثنتين
+
+33
+00:03:45,430 --> 00:03:51,930
+اللي هي يعني فيها
+
+34
+00:03:51,930 --> 00:03:57,630
+أكثر من شخص، مصادر، فلما يكون أبيض تمامًا معناته
+
+35
+00:03:57,630 --> 00:04:05,130
+سليم، الـGenotype، الـGenotype النصف معناته Carrier
+
+36
+00:04:05,130 --> 00:04:14,250
+والـFull مظلل بالكامل، هذا معناته إنسان مصاب، فهيك
+
+37
+00:04:14,250 --> 00:04:20,530
+الواحد بدّه يقراهم، ماشي؟ فأنا ما فهمتش الزوج
+
+38
+00:04:20,530 --> 00:04:24,930
+والزوجة هنا، شو الـGenotype، الـGenotype، هاي مصابة
+
+39
+00:04:24,930 --> 00:04:32,710
+وهي بدها تكون Free، لما نقول Carrier، معناته هذه
+
+40
+00:04:32,710 --> 00:04:35,350
+الصفة متنحية، ماشي؟
+
+41
+00:04:38,620 --> 00:04:44,520
+ممكن تكون متنحية، ممكن تكون .. إذا في .. يعني هنا
+
+42
+00:04:44,520 --> 00:04:47,200
+بتتكلموا على أن أحيانًا
+
+43
+00:04:49,880 --> 00:04:56,960
+إحنا بنتكلم عن صفة، يعني إحنا اللي بنحب هيك نفهمها
+
+44
+00:04:56,960 --> 00:05:02,480
+بسهولة، وأبسط شيء، فيه سائد وفيه متنحي، أن السائد هو
+
+45
+00:05:02,480 --> 00:05:07,360
+اللي بيظهر، والمتنحي بيختفي إلا إذا كان two copies
+
+46
+00:05:07,360 --> 00:05:13,140
+هذا الكلام مش دائمًا 100% بهذه الطريقة، هذا الكلام
+
+47
+00:05:13,140 --> 00:05:24,740
+أحيانًا مش كامل، من ناحية أن أحيانًا الصفة
+
+48
+00:05:24,740 --> 00:05:30,300
+الوراثية ما بتبين في مجموعة معينة، أو في ناس معينين
+
+49
+00:05:30,300 --> 00:05:37,360
+بشكل قوي، فبتلاقيها مش ظاهرة، يعني فهي النقطة اللي
+
+50
+00:05:37,360 --> 00:05:43,060
+بيحب واحد منكم يسألها، والمقصود في الموضوع أنه يتعود
+
+51
+00:05:43,060 --> 00:05:50,300
+الواحد يقرأ عن الصفة الوراثية، كيف يقرأ الـPedigree
+
+52
+00:05:50,300 --> 00:05:55,520
+"Choose Simple"، معناته هنا في ذكور وفي إناث
+
+53
+00:05:55,520 --> 00:06:01,440
+مصابين، وفي كل الأجيال بشكل واضح، وإن كان الجيل
+
+54
+00:06:01,440 --> 00:06:07,920
+الثاني هنا ما فيه مصابين، فيه Carriers اللي متوفر
+
+55
+00:06:07,920 --> 00:06:12,820
+رقم ثلاثة، أنثى، ما بنعرفش كانت مصابة ولا غير مصابة
+
+56
+00:06:12,820 --> 00:06:26,090
+واضح أن الصفة يعني فيه تفاوت فيها، يعني هو
+
+57
+00:06:26,090 --> 00:06:32,530
+أنا لما اتكملوا بالنسبة للـPedigree، ما حطّوش كل
+
+58
+00:06:32,530 --> 00:06:37,490
+المعلومات الأخرى، يعني أخذوا عائلة واحدة فقط من جانب
+
+59
+00:06:37,490 --> 00:06:42,730
+واحد، يعني الشاب
+
+60
+00:06:42,730 --> 00:06:49,430
+هذا، أو الرجل هذا، حتى جابوا الثلاث أفراد هدول، لازم
+
+61
+00:06:49,430 --> 00:06:53,590
+يتزوج بواحدة، هذه أيضًا ليست محطوطة، يعني فهنا فيه
+
+62
+00:06:53,590 --> 00:07:00,630
+معلومات مش كاملة، بس على الأقل يعني الواحد يعني هنا
+
+63
+00:07:00,630 --> 00:07:06,590
+carrier، أو مش واضح، يعني هيك بنعتبرها، وفيه أنه
+
+64
+00:07:06,590 --> 00:07:10,640
+مصابين، وفيه أنه غير مصابين، أتمنى أن إن شاء الله
+
+65
+00:07:10,640 --> 00:07:19,320
+تكون الصورة أوضحت لكم بالنسبة لسؤال الطالب، لأنه كانت
+
+66
+00:07:19,320 --> 00:07:27,500
+الأمور واضحة، في أسئلة؟ في أسئلة أخرى عن اللي
+
+67
+00:07:27,500 --> 00:07:31,980
+تَناولناها المرة اللي فاتت؟
+
+68
+00:07:31,980 --> 00:07:36,780
+طيب
+
+69
+00:07:37,630 --> 00:07:46,370
+بالنسبة لليوم، بدنا نحاول نفهم لما نتكلم عن
+
+70
+00:07:46,370 --> 00:07:55,550
+الوراثة والـGenetics في population بالنسبة للجنس
+
+71
+00:07:55,550 --> 00:08:03,370
+البشري كله، بكلام عام، شو الأسس، وكيف نتكلم، وكيف
+
+72
+00:08:03,370 --> 00:08:10,930
+نتعامل مع موضوع زي هذا، في مفهوم حتى نعرف أيّه يكون
+
+73
+00:08:10,930 --> 00:08:21,870
+عندنا مرتكز نبدأ منه في قضية فهم، يعني كيفية
+
+74
+00:08:21,870 --> 00:08:29,230
+التعامل مع الوراثة، في مفهوم يسمونه
+
+75
+00:08:29,230 --> 00:08:33,650
+قانون Hardy-Weinberg، القانون هذا قانون الوراثة
+
+76
+00:08:33,650 --> 00:08:44,570
+بسمّيه قانون التوازن الوراثي، أنه بالنسبة له، عند وجود جين
+
+77
+00:08:44,570 --> 00:08:54,330
+أصلي ومتغير قليل له، أو شكل آخر منه، لما نكون هذول
+
+78
+00:08:54,330 --> 00:09:01,290
+اثنين موجودين في البشرية، في الـPopulation كلها
+
+79
+00:09:01,290 --> 00:09:10,520
+القانون هذا راح نأخذه بعد شوية، كيف بتعامل مع نسب
+
+80
+00:09:10,520 --> 00:09:19,740
+تواجد كل قليل، بفترض هذا القانون بعض الافتراضات، بدي
+
+81
+00:09:19,740 --> 00:09:26,620
+الواحد يكون منتبه لها، عشان لما يتعامل يعني يكون
+
+82
+00:09:26,620 --> 00:09:32,600
+منتبه الواحد منها لاختلاف هذه الفرضية عن الواقع
+
+83
+00:09:32,600 --> 00:09:42,400
+أحيانًا الـ الـ الـ الـ population أو المجموعة اللي
+
+84
+00:09:42,400 --> 00:09:48,940
+إحنا بندرسها، الأصل حتى نطبق هذا
+
+85
+00:09:48,940 --> 00:09:53,520
+القانون، ونعرف نشتغل بالمعادلة تبعته، ونسوي الأشياء
+
+86
+00:09:53,520 --> 00:10:00,060
+اللي فيه، لازم تكون population كبيرة، والتزاوج بين
+
+87
+00:10:00,060 --> 00:10:09,210
+أفراده كلهم مسموح، وبيحدث، ويعني مش مثلًا population
+
+88
+00:10:09,210 --> 00:10:15,310
+فيها two sub-populations، يعني مثلًا في أمريكا
+
+89
+00:10:15,310 --> 00:10:20,350
+مثلًا نفترض البيض ما بيجوزوش السود، والسود ما بيجوزوش
+
+90
+00:10:20,350 --> 00:10:26,010
+البيض، ففي أمريكا مثلًا مجتمع نصف، ثلاثين، عشرين،
+
+91
+00:10:26,010 --> 00:10:32,830
+ثلاثين، خمسة عشر بالمية سود، وخمسة وثمانين تقريبًا
+
+92
+00:10:32,830 --> 00:10:39,090
+بالمية بيض، وما فيه تزاوج بينهم، إذا كان الأمر بهذه
+
+93
+00:10:39,090 --> 00:10:42,690
+الطريقة راح يخربط الدنيا، ومش راح يكون القانون اللي
+
+94
+00:10:42,690 --> 00:10:49,350
+نحكي عنه منطبق، فهو لـPopulation كبيرة بتكون
+
+95
+00:10:49,350 --> 00:10:55,330
+إمكانية التزاوج بين أفراده مسموحة، وما فيه أي
+
+96
+00:10:55,330 --> 00:11:03,110
+محددات، ماشي؟ فهذه ناحية مهمة ومبدأ، لما نطبق
+
+97
+00:11:03,110 --> 00:11:13,870
+القانون، الشيء الثاني أنه لما ندرسنا احتمالية، أو
+
+98
+00:11:13,870 --> 00:11:18,810
+نسبة حدوث المتغير
+
+99
+00:11:18,810 --> 00:11:26,730
+من نوع ما، للجين المتغير A أو B مثلًا، سنجد أن
+
+100
+00:11:26,730 --> 00:11:32,790
+الافتراض الثاني في القانون، أن النسب ثابتة، يعني
+
+101
+00:11:32,790 --> 00:11:38,710
+مثلًا في Population، في نسبة القليل الأول تسعين
+
+102
+00:11:38,710 --> 00:11:42,570
+بالمية، القليل الثاني عشرة بالمية من الناس عندهم هي
+
+103
+00:11:42,570 --> 00:11:49,580
+هكذا، فمن يكون عشرة أو تسعين، هذه النسبة ثابتة، من إنها
+
+104
+00:11:49,580 --> 00:11:58,000
+ما بتتغيرش بسبب حدوث طفرات جديدة، بتكون أن التزاوج
+
+105
+00:11:58,000 --> 00:12:04,620
+مسموح، وما فيه اختيار للنوع باتجاه نوع معين، وما فيه
+
+106
+00:12:04,620 --> 00:12:10,220
+أي نوع من إدخال أو إخراج نسبة من الناس من خلال
+
+107
+00:12:10,220 --> 00:12:18,340
+الهجرات، فالـImmigration، يعني المطلوب أن حتى نطبق
+
+108
+00:12:18,340 --> 00:12:23,840
+القانون اللي راح نحكي عنه، راح يكون من خلال بيسموها
+
+109
+00:12:23,840 --> 00:12:29,700
+الـSteady State، حالة الاتزان، حالة الثبات، فهذه
+
+110
+00:12:29,700 --> 00:12:38,740
+محددات أساسية في الرؤية، لما نيجي نتكلم عن، يعني
+
+111
+00:12:38,740 --> 00:12:44,300
+النسب، والـ كافة الـDiversity في المجتمع، أو في الـ
+
+112
+00:12:44,300 --> 00:12:49,280
+Population، بدنا نأخذها بعالي اعتبار، إذا أخذنا هذه
+
+113
+00:12:49,280 --> 00:12:58,060
+النقاط بعالي اعتبار، لما نيجي نتكلم عن، يعني
+
+114
+00:12:58,060 --> 00:13:08,100
+كيف ننصف تفاوت البشر بالنسبة لصفة معينة ووراثية، فهنا
+
+115
+00:13:08,100 --> 00:13:17,840
+أعطيكم مثال على جزيء، أو على جزئية، أو على، يعني
+
+116
+00:13:17,840 --> 00:13:24,640
+بروتين اللي يسمّوه CCR5، الـChemokines، هذول عبارة
+
+117
+00:13:24,640 --> 00:13:30,840
+عن مجموعة هرمونات بتتحكم في المناعة، بتحدد وين
+
+118
+00:13:30,840 --> 00:13:40,030
+الخلايا بتروح، فالـChemokines عددهم كبير، ويعني
+
+119
+00:13:40,030 --> 00:13:43,910
+حوالي ما لا يقل عن مئة، يمكن أكثر، أو أكثر
+
+120
+00:13:43,910 --> 00:13:48,330
+اكتشفوا كلها، عشان تخلّي خلايا المناعة تعرف أين
+
+121
+00:13:48,330 --> 00:13:55,490
+تروح، فالـChemokines الأهم والأشهر هم الـReceptors
+
+122
+00:13:55,490 --> 00:14:02,350
+تبعتهم، هم المستقبلات تبعتهم، فعددهم بيسمّوه حسب الـ
+
+123
+00:14:02,350 --> 00:14:09,430
+Cytosine، اللي هو Amino Acid، Cytosine
+
+124
+00:14:09,430 --> 00:14:13,110
+Amino
+
+125
+00:14:13,110 --> 00:14:20,560
+Acid Particle، أو Amino Acid بالـVolume بتاعهم، فبيجي
+
+126
+00:14:20,560 --> 00:14:25,160
+اثنتين وراء بعض، فبيسموهم CC، أنه اثنتين وراء بعض، مش
+
+127
+00:14:25,160 --> 00:14:33,940
+CXC أو CXXC، يعني أنه فيه Amino Acid بينهم، المهم،
+
+128
+00:14:33,940 --> 00:14:41,800
+الـChemokine رقم خمسة شيء مهم كمستقبل للـHIV
+
+129
+00:14:41,800 --> 00:14:49,410
+الـHIV، إذا تتذكروا، بيستخدم الـCD4، الـGP120 على
+
+130
+00:14:49,410 --> 00:14:56,090
+الـsurface تبع الـ البروتين تبع الـHIV، الفيروس
+
+131
+00:14:56,090 --> 00:15:01,590
+الـHuman Immune Deficiency Virus، فالـ الـHIV
+
+132
+00:15:01,590 --> 00:15:07,510
+بيستخدم الـCD4، جزيء اللي على سطح الـT-cells
+
+133
+00:15:07,510 --> 00:15:13,210
+والـCCR5 على سطح الـT-cells، المستقبل الثاني إليه
+
+134
+00:15:13,210 --> 00:15:23,580
+فكانت ملاحظة من فترة، أو كان عليها ضجة كبيرة، أن في
+
+135
+00:15:23,580 --> 00:15:31,900
+بعض الـVariation في قابلية الخلايا إنها يتم غزوها
+
+136
+00:15:31,900 --> 00:15:40,320
+من خلال الـHIV، من خلال Variations في الـCCR5، ففي
+
+137
+00:15:40,320 --> 00:15:46,440
+نوع اكتشفناه بعدين، بعض الناس عندهم "Delta CCR5"
+
+138
+00:15:46,440 --> 00:15:53,120
+"Deletion Elite"، يعني بيصير عندهم أن الـ"CCR5"
+
+139
+00:15:53,120 --> 00:15:57,940
+غير موجود بشكل طبيعي، عبارة عن بروتين مقطوع،
+
+140
+00:15:57,940 --> 00:16:06,740
+بروتين، مش اسمه بروتين مقطوع، بكون فيه stop codon
+
+141
+00:16:06,740 --> 00:16:14,300
+وبيكون miss shift، يعني الـdeletion خلت أن قراءة
+
+142
+00:16:14,300 --> 00:16:20,100
+الـDNA مش مظبوطة، وبالتالي ما فيه أن الـCCR5
+
+143
+00:16:20,100 --> 00:16:26,020
+القليل اللي هو مش طبيعي، بكون فيه مشكلة فيه
+
+144
+00:16:30,070 --> 00:16:35,070
+راح نتفرج بعد شوية على كيف أنه بالنسبة كـ
+
+145
+00:16:35,070 --> 00:16:39,490
+Population لهذا الجين
+
+146
+00:16:39,490 --> 00:16:48,310
+بالذات تم دراسته، ونشوف كيف النتائج راح تكون، فكان
+
+147
+00:16:48,310 --> 00:16:53,030
+فيه اهتمام بهذا الموضوع، لأنه كان يفسر مقاومة البعض
+
+148
+00:16:53,030 --> 00:16:58,110
+للـHIV، قدرتهم على أنه يتعرضوا إليه بس ما ينصابوا
+
+149
+00:16:58,110 --> 00:17:07,330
+فكان مثير للاهتمام، لما أجوا ودرسوا المعادلات
+
+150
+00:17:07,330 --> 00:17:12,610
+أو درسوا الوضع اللي موجود بالنسبة للـ
+
+151
+00:17:16,390 --> 00:17:23,370
+بين الـCCR5 وبين الأليل اللي هو الـMutated، اللي
+
+152
+00:17:23,370 --> 00:17:33,210
+هو فيه الـDeletion اللي هو المقطوع، فدرسوا 788 شخص
+
+153
+00:17:33,210 --> 00:17:38,210
+الكلام بالـ1997، ماشي، يعني يعني يعتبر دراسة قديمة
+
+154
+00:17:38,210 --> 00:17:46,880
+نوعًا ما، درسوا حوالي 800 بني آدم، الـ الـ البشر
+
+155
+00:17:46,880 --> 00:17:53,160
+اللي عندهم الـtwo copies normal، ماشي، حوالي 651
+
+156
+00:17:53,160 --> 00:17:59,160
+اللي عندهم نسخة واحدة من الـDeletion، أو
+
+157
+00:17:59,160 --> 00:18:06,480
+الـAbnormal قليل، مش الـWild type، 134، واللي عندهم
+
+158
+00:18:06,480 --> 00:18:13,040
+Double the thing، اللي هو الـMutations، اثنتين
+
+159
+00:18:13,040 --> 00:18:25,060
+سبعة، فلما نحملها نسب، راح نلاقي أن الـone كاملة هي
+
+160
+00:18:25,060 --> 00:18:35,960
+الـtotal للكل، 82% عندهم الـwild type، 17% تقريبًا
+
+161
+00:18:35,960 --> 00:18:43,840
+عندهم one mutation، واحد بالمية عندهم اللي هو الـ
+
+162
+00:18:43,840 --> 00:18:51,100
+Double Mutations، وهي الأليل، وهي اسمها Derived
+
+163
+00:18:51,100 --> 00:18:59,250
+Frequencies، الأليل، الفكرة من هنا أنه لما نيجي نأخذ،
+
+164
+00:18:59,250 --> 00:19:04,490
+طبعًا هنا عرفنا عنه أنه بس فيه عندنا اثنين، ما عندناش عدد
+
+165
+00:19:04,490 --> 00:19:08,210
+أكبر من الـAlleles، يعني مثلًا لما نيجي نقول أنه
+
+166
+00:19:08,210 --> 00:19:12,370
+نطبق القاعدة هذه، وبهذه الطريقة تمامًا على الـABO
+
+167
+00:19:12,370 --> 00:19:17,250
+System تبع الـBlood Group، الـABO System، لأ، فيه
+
+168
+00:19:17,250 --> 00:19:20,770
+ثلاثة Alleles، فما بيمشي عليه هذا القانون، ما بتمشي
+
+169
+00:19:20,770 --> 00:19:24,650
+عليه هذه الطريقة، إنما لما يكون عندي بس Two copies
+
+170
+00:19:24,650 --> 00:19:30,810
+يعني مثلًا الـRh Positive و Negative تبع الـ
+
+171
+00:19:30,810 --> 00:19:35,990
+Rhesus Factor، أو الـBlood Group الـRh، في حالة
+
+172
+00:19:35,990 --> 00:19:40,390
+مثلًا الـRh، ممكن أنا أطلع أرقام زي هيك، وأقول أن
+
+173
+00:19:40,390 --> 00:19:46,890
+البشر مثلًا كذا بالمية عندهم هيك، وكذا بالمية عندهم
+
+174
+00:19:46,890 --> 0
+
+223
+00:25:17,850 --> 00:25:25,650
+مع «Aa» يعني إذا مثلًا إثنينهم هيتروا زيكِ مثلًا
+
+224
+00:25:25,650 --> 00:25:34,510
+«Aa» هاي راح يطلع عنها «4Q2B²Q²»
+
+225
+00:25:34,510 --> 00:25:35,530
+«4Q2B²Q²» «4Q2B²Q²» «4Q2B²Q²» «4Q2B²Q²» «4Q2B²Q²»
+
+226
+00:25:35,530 --> 00:25:36,950
+«4Q2B²Q²» «4Q2B²Q²» «4Q2B²Q²» «4Q2B²Q²» «4Q2B²Q²»
+
+227
+00:25:36,950 --> 00:25:36,990
+«4Q2B²Q²» «4Q2B²Q²» «4Q2B²Q²» «4Q2B²Q²» «4Q2B²Q²»
+
+228
+00:25:36,990 --> 00:25:43,320
+«4Q2B²Q²» «4Q2B²Q²» «هذولا إثنين هما يعني الـ
+
+229
+00:25:43,320 --> 00:25:49,300
+Offspring راح يكون الرُبع AA Capital، الرُبع AA
+
+230
+00:25:49,300 --> 00:25:58,920
+Small أو Recessive، والنُص راح يكونوا Heterozygous
+
+231
+00:25:58,920 --> 00:26:10,400
+فهي يعني مدخل لكيف إحنا بنفكر لما نتكلم عن الـ
+
+232
+00:26:10,400 --> 00:26:19,160
+Frequencies تبعات الـ Certain Genotypes، وكيف نسبهم
+
+233
+00:26:19,160 --> 00:26:24,320
+ووجودهم في المجتمعات، في الـ Population، وشو أهمية
+
+234
+00:26:24,320 --> 00:26:27,920
+دراسة هذا الموضوع؟ إذا في حد عنده سؤال، يعني
+
+235
+00:26:27,920 --> 00:26:39,060
+أنا…………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………
+
+236
+00:26:48,740 --> 00:26:57,620
+قليل لما تدرس نسبته تسميها الـP، الـMutated أو
+
+237
+00:26:57,620 --> 00:27:00,660
+الجين
+
+238
+00:27:00,660 --> 00:27:06,340
+الثاني اللي خربان أو فيه مرض أو فيه مشكلة تسميه
+
+239
+00:27:06,340 --> 00:27:15,170
+الـQ. فإذا هنا لدراسة صفة معينة عندك Two Genes زي ما
+
+240
+00:27:15,170 --> 00:27:21,790
+حكينا عن مثال الـ «Gene» تبع الـ «CCR5»، عبارة عن
+
+241
+00:27:21,790 --> 00:27:30,550
+إحنا اهتمينا في دراسته لأنه يمثل احتمالية
+
+242
+00:27:30,550 --> 00:27:35,250
+الإصابة بالـ «HIV»، والـ «Susceptibility» تبعته
+
+243
+00:27:35,250 --> 00:27:37,650
+يعني، لماذا بعض الناس بينصاب، ولماذا بعض الناس
+
+244
+00:27:37,650 --> 00:27:42,350
+بينصابوا؟ فدرست هذا الـ «Gene»، فانتبهت إنه عندي
+
+245
+00:27:42,350 --> 00:27:48,170
+إثنين منهما، فالـ Wild-type العادي الأصلي بسمي الـ
+
+246
+00:27:48,170 --> 00:27:53,050
+Frequency تبعته، نسبة حدوثه في الاحتمالات بأعطيها
+
+247
+00:27:53,050 --> 00:28:01,290
+الرقم P، والـ Q هي نسبة الطفرة، اللي هي قد إيش نسبة
+
+248
+00:28:01,290 --> 00:28:08,350
+حدوثها، على أساس أنه زي ما رسمناه هنا بالمثال هذا
+
+249
+00:28:08,350 --> 00:28:15,440
+الـ P هي الـ Frequency تبعت الـ CCR5، بنعطيها الـ «0
+
+250
+00:28:15,440 --> 00:28:22,200
+.9»، وهذه بأعطيها «P»، والـ «Delta» «CCR5» الـ
+
+251
+00:28:22,200 --> 00:28:28,300
+«Mutated»، «Deleted»، قليل بأعطيها «0.09»، يعني «0.1
+
+252
+00:28:28,300 --> 00:28:34,660
+%»، يعني عشرة بالمية، هيك تسعة بالمية «P»، وعشرة
+
+253
+00:28:34,660 --> 00:28:43,020
+بالمية الـ «Q». كل المعادلات اللي بيحكونا عنها هو
+
+254
+00:28:43,020 --> 00:28:52,760
+أعقد مثال لـ «جين 1»، واضحة؟ دكتور، أسماء كانت
+
+255
+00:28:52,760 --> 00:28:57,000
+تسأل كيف الشقة التانية، بس يبدو وصلتها الفكرة
+
+256
+00:28:57,000 --> 00:29:00,880
+«كريم» بيقول يعني، «شو بتفيد دي؟ هذه المعادلة؟»
+
+257
+00:29:00,880 --> 00:29:03,580
+يعني إيش المقصود بالـ frequency؟ مرة أخرى بيسأل
+
+258
+00:29:04,650 --> 00:29:14,370
+الآن نأتي مثلًا، نأخذ موضوع، دائمًا أحب أن نضرب مثال
+
+259
+00:29:14,370 --> 00:29:21,470
+عليه مثلًا، بنك الدم، أنا
+
+260
+00:29:21,470 --> 00:29:31,630
+بهمني عشان أسهّل إعطاء دم للناس حسب نسب الـA والـB
+
+261
+00:29:31,630 --> 00:29:39,000
+والـO group، بهمني يعني هذا مثال مش راح يظبط تمامًا
+
+262
+00:29:39,000 --> 00:29:46,060
+مية بالمئة، بس بدي أوصل فكرة معينة بالنسبة لما أنا
+
+263
+00:29:46,060 --> 00:29:50,460
+آجي، كم نسبة الـA، وكم نسبة الـO، وكم نسبة الـB
+
+264
+00:29:50,460 --> 00:30:01,060
+بتفيدني، يعني أنا مثلًا في بنك دم وبدي أجهّز مثلًا
+
+265
+00:30:01,060 --> 00:30:07,490
+لِمعركة أو لاحتياجي في مدة طويلة أو كذا، فبهمني
+
+266
+00:30:07,490 --> 00:30:15,770
+أعرف كم نسبة كل قليل موجود، وقد إيش أجهّز من هذا
+
+267
+00:30:15,770 --> 00:30:20,810
+وقد إيش أجهّز من هذا، وشو أعمل لكذا ولهيك، فأحيانًا
+
+268
+00:30:20,810 --> 00:30:25,530
+لما تيجي، وراح نأخذ أمثلة أخرى لاستفادات لهذه
+
+269
+00:30:25,530 --> 00:30:35,870
+النسب أو لهذه الـ Frequency اللي هي يعني نسبة حدوث
+
+270
+00:30:35,870 --> 00:30:42,630
+أو احتمالية حدوثها تكون بشكل معيّن، فالـ يعني اللي
+
+271
+00:30:42,630 --> 00:30:46,650
+بدّك تأخذه بس خلّينا نعدي هاي شوية، بتشوف إنّها لي
+
+272
+00:30:46,650 --> 00:30:52,010
+كيف أشياء مفيدة أنك تعرف هذه الأرقام، الـ P هي الـ
+
+273
+00:30:52,010 --> 00:31:04,380
+Frequency تبعت الـ Wild-type gene، الـ Q هي نسبة الـ
+
+274
+00:31:04,380 --> 00:31:10,000
+Frequency تبع الـ Mutated Genes، المثال اللي حطيناه
+
+275
+00:31:10,000 --> 00:31:17,260
+من قبل شوية اللي هو CCR5 وDelta CCR5، كانت النسب في
+
+276
+00:31:17,260 --> 00:31:23,140
+Population، يعني أنا بفرجيك إياها بهذا الشكل، يعني
+
+277
+00:31:23,140 --> 00:31:24,060
+هذا مثال
+
+278
+00:31:28,510 --> 00:31:34,770
+لما درسوا في Population
+
+279
+00:31:34,770 --> 00:31:41,550
+مختلفة، في أماكن مختلفة، في مدن وفي بلاد مختلفة، ما
+
+280
+00:31:41,550 --> 00:31:49,970
+هي الـ Frequency تبعت الـ Delta CCR5، إحنا حكينا
+
+281
+00:31:49,970 --> 00:31:57,670
+التقدير المتوسط حسب تلك الدراسة 9% أو Point أو 10%
+
+282
+00:31:57,670 --> 00:32:03,010
+يعني هنا تقريبًا، فاللي بدي أفرجيك إياها إنه في
+
+283
+00:32:03,010 --> 00:32:08,490
+المناطق اللي تم دراسة الموضوع هذا، بلاد مثلًا زي
+
+284
+00:32:08,490 --> 00:32:16,910
+هنا الصين، بنجلاديش، الهند، باكستان، السعودية، النسبة
+
+285
+00:32:16,910 --> 00:32:24,350
+لـ «CCR5»، «Delta CCR5» اللي هو الـ Mutated Gene
+
+286
+00:32:24,350 --> 00:32:29,850
+كانت نسبة قليلة جدًا، صفر في Population معينة
+
+287
+00:32:29,850 --> 00:32:38,470
+بينما فيه لما ندرسه مثلًا في أماكن زي شمال أوروبا
+
+288
+00:32:38,470 --> 00:32:44,370
+في هذا المكان زي فنلندا والسويد والدنمارك والـ
+
+289
+00:32:44,650 --> 00:32:49,350
+بولندا، يمكن هنا لقوا
+
+290
+00:32:49,350 --> 00:32:56,690
+نسبة الـ Mutated Genes ضعف أو أضعاف الـ 18%، نسبة
+
+291
+00:32:56,690 --> 00:33:01,770
+عالية، كثيرة، فهذا حسب الدراسات، يعني هنا هذه نوع من
+
+292
+00:33:01,770 --> 00:33:10,330
+الخارطة العالمية لتفاوت الـ population، أنتم
+
+293
+00:33:10,330 --> 00:33:14,390
+تشاهدون الصورة الكاملة بما فيه الـ Caption تبعتها،
+
+294
+00:33:14,390 --> 00:33:23,510
+صح؟ الـ… هنا الـDelta CCR5 أليل in various
+
+295
+00:33:23,510 --> 00:33:27,810
+geographical regions in Europe and Middle East
+
+296
+00:33:27,810 --> 00:33:31,790
+and Indian subcontinent، في أماكن في العالم، الصورة
+
+297
+00:33:31,790 --> 00:33:38,510
+بهذا الشكل، بتخلّي إنه نسبة حدوث، لما ركّزوا على إنهم
+
+298
+00:33:38,510 --> 00:33:43,880
+يهتموا بهذا النوع من الـGene Mutation، لقوا إنه فيه
+
+299
+00:33:43,880 --> 00:33:51,420
+تفاوت بين البشر بالنسب، بس هذه يعني نوع من، بالأخير
+
+300
+00:33:51,420 --> 00:33:55,100
+يعني عرفوا يرسموا الصورة هذه من الـ Frequency تبعت
+
+301
+00:33:55,100 --> 00:34:02,720
+الـ Alleles اللي هي الـ P والـ Q، ماشي؟ هنا اللي
+
+302
+00:34:02,720 --> 00:34:09,950
+ممثّل بالرمز هنا هو الـ Q، ماشي؟ وكل ما كانت نسبته
+
+303
+00:34:09,950 --> 00:34:16,870
+أكبر، شو اسمه؟ بتكون الأمور بهذا الشكل، بس بدي أذكر
+
+304
+00:34:16,870 --> 00:34:23,990
+إنه هذا الآن على نموذج افتراضي، اللي هو الـ Hardy
+
+305
+00:34:23,990 --> 00:34:28,350
+-Weinberg Law، وبكون إنه population stable،
+
+306
+00:34:28,350 --> 00:34:32,310
+population ما فيش فيها migration، ما فيش فيها new
+
+307
+00:34:32,310 --> 00:34:38,390
+mutation، الـ mating أو الزواج مفتوح في كل الاتجاهات
+
+308
+00:34:38,390 --> 00:34:49,590
+فهو مثال على دراسة تمت أو دراسات تمت لفهم تفاوت
+
+309
+00:34:49,590 --> 00:34:57,510
+البشر في نوعية mutation معينة، بطفرة معينة، هنا بدنا
+
+310
+00:34:57,510 --> 00:35:02,630
+نسميها polymorphism، يعني ما ما أقدر أعتبرها زي
+
+311
+00:35:02,630 --> 00:35:06,350
+الـGenetic mutation اللي هي very very very rare
+
+312
+00:35:06,960 --> 00:35:11,800
+اللي مثلًا، طبعًا الـ Frequency للـ Polymorphism
+
+313
+00:35:11,800 --> 00:35:17,980
+بذكر هي الـ 1%، إذا الواحد أكثر من 1% معناته
+
+314
+00:35:17,980 --> 00:35:26,540
+Frequent، ماشي، في سؤال عن المعادلات
+
+315
+00:35:26,540 --> 00:35:32,360
+هذه؟ أمثلة على كيف بعدين نستفيد من المعادلات بحيث
+
+316
+00:35:32,360 --> 00:35:37,270
+أنه يعني هذا راح نحتاجه في قضية بين قوسين الـ
+
+317
+00:35:37,270 --> 00:35:45,590
+Genetic Counseling، لما ييجي مثلًا عائلة عندهم مثلًا
+
+318
+00:35:45,590 --> 00:35:49,550
+مرض معيّن بيّن بالطفل الأول، واتوفى الله يرحمه بعدين
+
+319
+00:35:49,550 --> 00:35:55,110
+الله، أخذوا داعته وتوفى الطفل الأول، بيرجعوا لو كان
+
+320
+00:35:55,110 --> 00:36:02,320
+عندنا تصوّر ما هو نوعية الـ Frequency تبع الـ Gene
+
+321
+00:36:02,320 --> 00:36:07,360
+Mutation؟ وما هو نوعية الـ Inheritance؟ وما هي
+
+322
+00:36:07,360 --> 00:36:12,310
+المعادلات التي أستطيع أستفيد منها؟ ممكن أعطي
+
+323
+00:36:12,310 --> 00:36:17,030
+احتمالية تساعد الأهل هذول أن يقرروا يخلفوا مرة
+
+324
+00:36:17,030 --> 00:36:21,490
+ثانية ولا ما يخلفوش مرة ثانية ولا يعملوا إشي ولا
+
+325
+00:36:21,490 --> 00:36:25,610
+يتطلقوا ولا يبقى ما فيش داعي كام للزواج مع بعض وكذا
+
+326
+00:36:25,610 --> 00:36:31,250
+يعني إحنا بنعمل نوع من هذا الأمر مثلًا يعني اللي هو
+
+327
+00:36:31,250 --> 00:36:34,930
+فحص قبل الزواج بالنسبة لقضية الثلاسيميا وأمراض
+
+328
+00:36:34,930 --> 00:36:42,230
+الدم، الثلاسيميا أو أمراض الدم تجد أنه يعني الأصل أن
+
+329
+00:36:42,230 --> 00:36:49,990
+الواحد، إذا اثنين من الأشخاص، الزوج والزوجة مقبلين
+
+330
+00:36:49,990 --> 00:36:55,830
+على الزواج، الاثنين هما عندهم طفرة بشكل معيّن بتخلّينا
+
+331
+00:36:55,830 --> 00:37:01,550
+ننصح إنه والله يعني اللي هي مبدأ حديث الرسول صلى
+
+332
+00:37:01,550 --> 00:37:06,190
+الله عليه وسلم «تزوّجوا في النكاح أو تَرَبّوا فقدِ اُتّهموا»
+
+333
+00:37:06,190 --> 00:37:11,110
+يعني لا تضمروا إنه واحد يظل ياخذ من أقاربه وإنه
+
+334
+00:37:11,110 --> 00:37:17,690
+يبعد في الزواج وكذا وكذا، فهذه مبادئ يعني مرتبطة بإن
+
+335
+00:37:17,690 --> 00:37:24,040
+الواحد يكون عنده تصوّر كم نسبة حدوث كل نوع من الـ
+
+336
+00:37:24,040 --> 00:37:29,700
+Genotypes، ويكون الـ Wild-type اللي هو الـ P والـ
+
+337
+00:37:29,700 --> 00:37:37,460
+والطفرة أو الـ Mutation اللي هي الـ Q، وفي حالة الـ
+
+338
+00:37:37,460 --> 00:37:44,540
+Steady State، في حالة لما يكون ما فيش يعني مُغيّرات
+
+339
+00:37:44,540 --> 00:37:50,050
+بتأثر على الموضوع هذا، ويكون الأمور Stable، بيكون
+
+340
+00:37:50,050 --> 00:37:56,130
+مجموع القيم واحد، تساوي كل total بتساوي واحد، وتكون
+
+341
+00:37:56,130 --> 00:38:01,770
+بهذا الشكل، في أسئلة؟
+
+342
+00:38:01,770 --> 00:38:09,890
+في سؤال يا دكتور من كريم، بيقول إنه، ألجيت أنا لما
+
+343
+00:38:09,890 --> 00:38:16,980
+أعرف إن الـ frequency للأبوين هو Q⁴، هذا بيؤثر، مش
+
+344
+00:38:16,980 --> 00:38:27,480
+عارف هو إيه السؤال كان؟ شوف، بالنسبة لما يكونوا
+
+345
+00:38:27,480 --> 00:38:32,720
+الـ offspring أو الـ 4Q جزء، وآسف، الـ 4Q يمكن هذا
+
+346
+00:38:32,720 --> 00:38:38,280
+بيعنى إنهم عرضة للطفرات أكثر من اللي عندهم الـ 4B
+
+347
+00:38:38,280 --> 00:38:46,310
+يعني، بيسأل، يعني هيك صح الاستنتاج تبعه؟ لأ لأ،
+
+348
+00:38:46,310 --> 00:38:57,450
+الآن شوف، افرض، خلّيني نرجع نشرحها مرة أخرى، افرض الـ
+
+349
+00:38:57,450 --> 00:39:02,550
+«CCR5»
+
+350
+00:39:02,550 --> 00:39:08,670
+هذا الـ «فيتال» اللي أخدناه، الـ Normal في 90%، الـ
+
+351
+00:39:08,670 --> 00:39:10,770
+«CCR5»، طيب
+
+352
+00:39:13,610 --> 00:39:20,430
+واحتمالية الطفرة 10%، خلّينا نأخذها بهذا الشكل،
+
+353
+00:39:20,430 --> 00:39:26,030
+تمام؟ دكتور، أخلي كريم يسأل السؤال تبعه
+
+354
+00:39:30,570 --> 00:39:36,550
+نعم، أنا فاهم إن الـ B معناته إنه لا يوجد فيه طفرة،
+
+355
+00:39:36,550 --> 00:39:43,450
+هذا شيء سائد، والـ Q هذا برمز للجيل المِحاط، صحيح؟
+
+356
+00:39:43,450 --> 00:39:52,490
+برمز للـ Frequency، للاحتمالية، كم تواجد هذا الجيل،
+
+357
+00:39:52,490 --> 00:39:58,710
+فإحنا مثلًا، لو قلت لك، زي المثال اللي حكينا، شو
+
+358
+00:39:58,710 --> 00:40:10,670
+احتمالية؟ إن إنسان عنده طفرتين، ماشي؟ بالنسبة لما
+
+359
+00:40:10,670 --> 00:40:18,850
+أنت تأخذ مثل هذا المثال، ماشي؟ الآن، بالأخير الـ P
+
+360
+00:40:18,850 --> 00:40:25,010
+هي الـ Frequency اللي هي نسبة حدوث إنه يكون CCR5
+
+361
+00:40:25,010 --> 00:40:33,870
+فهي 90%، Point Nine، والـ «دلتا CCR5» Point one
+
+362
+00:40:33,870 --> 00:40:39,630
+يعني عشرة بالمئة، نفترض هيك، نقربها، ماشي؟ فأنا لو
+
+363
+00:40:39,630 --> 00:40:47,730
+سألتك قد إيش احتمالية واحد يكون عنده طفرتين، راح تقول
+
+364
+00:40:47,730 --> 00:40:53,490
+لي Point one to Point one بتساوي Point O one، فهذه
+
+365
+00:40:53,490 --> 00:40:59,840
+النسب اللي أنا بتوقعها، لأن هنا B تربيع اللي هي الـ
+
+366
+00:40:59,840 --> 00:41:07,580
+P هذه تربيع، وهنا Q تربيع، وهنا 2PQ، بس لو جبنا
+
+367
+00:41:07,580 --> 00:41:14,760
+بالمثال هذا، شو احتمالية الـ الـ الأم إذا اعتبرنا
+
+368
+00:41:14,760 --> 00:41:21,160
+احتمالية الـ A الواحدة هي P، ماشي؟ فشو احتمالية واحد
+
+369
+00:41:21,160 --> 00:41:29,490
+dominant AA mother تتزوج dominant الـ AA father، راح
+
+370
+00:41:29,490 --> 00:41:34,910
+يصير أنه يعني لما تيجي تأخذ بالـ population مثلًا
+
+371
+00:41:34,910 --> 00:41:45,690
+هي 90%، ماشي؟ 90% الـ A الـ dominant، والـ A small 0
+
+372
+00:41:45,690 --> 00:41:52,810
+.1، إذا أخذتها، فشو احتمالية أنه يكونوا AA capital
+
+373
+00:41:52,810 --> 00:42:01,300
+إذا تضرب P تربيع، وهذه P تربيع، ف الاحتمالية لـ
+
+374
+00:42:01,300 --> 00:42:05,100
+Frequency تبعت الـ AA والـ Offspring كلهم راح
+
+375
+00:42:05,100 --> 00:42:08,720
+يكونوا Capital A Capital A، راح يكونوا بهذا الشكل
+
+376
+00:42:08,720 --> 00:42:15,600
+ماشي؟ فإذا بتأخذها population معيّنة راح تلاقي
+
+377
+00:42:15,600 --> 00:42:22,920
+نسبتهم في ال population P تربيع، أو قُدرة أربعة راح
+
+378
+00:42:22,920 --> 00:42:28,460
+تلاقيها بهذا الشكل، يعني إذا 90% في 90% في 0.81
+
+379
+00:42:28,460 --> 00:42:34,900
+في 0.81 راح يطلع حوالي 64% من الـ Population
+
+380
+00:42:34,900 --> 00:42:41,080
+يعني هاي النسب لنوعية
+
+381
+00:42:41,080 --> 00:42:47,000
+الـ Mating، يعني النسب المتوقّعة، هذه أحيانًا معلومات
+
+382
+00:42:47,000 --> 00:42:51,200
+مهمّة ومفيدة، حكيت بالنسبة للـ Genetic Counseling
+
+383
+00:42:51,200 --> 00:42:57,420
+بالنسبة ل… يعني راح نأخذ تطبيقات لها في أفكار
+
+384
+00:42:57,420 --> 00:43:02,520
+معيّنة، بس حتى يظبط الكلام هذا نرجع مرة ثانية، بدّك
+
+385
+00:43:02,520 --> 00:43:05,960
+تنتبه إنه لازم تكون الـ Population في Steady State
+
+386
+00:43:05,960 --> 00:43:13,060
+والـ Mating مسموح، ما فيش أي محددات عليه، لأنه فيه
+
+387
+00:43:13,060 --> 00:43:17,800
+كمان محددات بتخرب على الموضوع هذا، أيوة كريم، في
+
+388
+00:43:17
+
+445
+00:48:42,810 --> 00:48:49,210
+أنا أحط الـFrequency يعني
+
+446
+00:48:49,210 --> 00:48:54,030
+كمثال هنا على الـColor Blindness اللي هو Vision
+
+447
+00:48:54,030 --> 00:49:03,370
+اللي هو عمل ألوان تبع الإبصار، فلما نأخذ على
+
+448
+00:49:03,370 --> 00:49:06,610
+الـX-Chromosome ماشي
+
+449
+00:49:08,580 --> 00:49:12,440
+وهنا نيجي طبعاً بسبب إنه الـmales عندهم one copy
+
+450
+00:49:12,440 --> 00:49:19,740
+بس، فإذا كان الـX wild type اللي هو الجين العادي
+
+451
+00:49:19,740 --> 00:49:29,840
+بيكون normal color، بجنها هي نسبتها 92% كجين للذكور
+
+452
+00:49:29,840 --> 00:49:39,830
+ماشي، نسبة الـcolor blindness 0.08، يعني 8%، الـQ
+
+453
+00:49:39,830 --> 00:49:44,750
+اللي هي نسبة الـgene، الـmutation تبع الـcolor
+
+454
+00:49:44,750 --> 00:49:53,110
+blindness، one copy بتكون بتكفي حتى يكون عندنا المرض عند
+
+455
+00:49:53,110 --> 00:49:58,610
+الرجال أو عند الذكور، بسبب أنه it is X-linked
+
+456
+00:49:58,610 --> 00:50:03,350
+recessive، والـfrequency تبعته هي 8 بالمئة لو
+
+457
+00:50:03,350 --> 00:50:12,710
+سألنا: شو نسبة؟ إذا هي الـfrequency للقليل 92% يعني
+
+458
+00:50:12,710 --> 00:50:16,810
+هي polymorphism، نعتبرها mutation، هي ليست
+
+459
+00:50:16,810 --> 00:50:21,130
+ميوتاشن، نعتبرها شيء موجود وبالـsteady state
+
+460
+00:50:21,130 --> 00:50:28,230
+موجود بهذه النسبة، شو نثبت إن أنت تكون Color Blind؟
+
+461
+00:50:28,230 --> 00:50:37,390
+فرح نقول 8% تربيع، اللي هي 64 من 10000، ماشي، يعني
+
+462
+00:50:37,390 --> 00:50:45,930
+حوالي 0.06%، أو 0.01%، يعني اللي هو نسبة
+
+463
+00:50:45,930 --> 00:50:53,470
+هذه، يعني اللي هي هاي بتعطينا اللي… اللي يكون
+
+464
+00:50:53,470 --> 00:50:59,370
+female، الـnot completely normal، homozygous normal
+
+465
+00:50:59,370 --> 00:51:06,320
+راح يكون 0.9 التربيع اللي هو المسبة هذه اللي حتكون
+
+466
+00:51:06,320 --> 00:51:11,760
+carrier، فيه Normal Heterozygous أو Combined Normal
+
+467
+00:51:11,760 --> 00:51:19,260
+Heterozygous اللي هو 2PQ بتكون هالجدة، وNormal اللي
+
+468
+00:51:19,260 --> 00:51:28,180
+هو Combined، بتلاقي يعني شو اللي هنا بيحكوه لما أنا
+
+469
+00:51:28,180 --> 00:51:34,960
+آجي على مستوى الـGene Frequency، الـ الـ الـ الـ الـ
+
+470
+00:51:34,960 --> 00:51:35,200
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+471
+00:51:35,200 --> 00:51:35,300
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+472
+00:51:35,300 --> 00:51:35,640
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+473
+00:51:35,640 --> 00:51:36,260
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+474
+00:51:36,260 --> 00:51:44,820
+الـ الـ الـ الـ الـ الـ الـ الـ
+
+475
+00:51:44,820 --> 00:51:48,600
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+476
+00:51:48,600 --> 00:51:48,620
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+477
+00:51:48,620 --> 00:51:50,400
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+478
+00:51:50,400 --> 00:51:50,520
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+479
+00:51:50,520 --> 00:51:56,100
+الـ الـ
+
+480
+00:51:56,100 --> 00:52:04,850
+الـ، ف اللي هو بيكون نسبته 2PQ اللي هو 0.147، الـ
+
+481
+00:52:04,850 --> 00:52:09,130
+“morphologically” أو الـ“phenotypically” “normal”
+
+482
+00:52:09,130 --> 00:52:12,990
+هو هذه المجموعة زائد هذه المجموعة، فتجمع هذول
+
+483
+00:52:12,990 --> 00:52:19,750
+الرقمين بيطلع 0.9936%، يعني راح يطلع لك الرقم هذا،
+
+484
+00:52:19,750 --> 00:52:23,930
+مجموع هاي زائد هاي، والـ“colorblind” بالـ“female”
+
+485
+00:52:24,820 --> 00:52:31,660
+اللي راح تكون Q تربيع، اللي هو راح يطلع فرق جداً
+
+486
+00:52:31,660 --> 00:52:38,220
+فهذا المثال، يعني لما نيجي نأخذ بالنسبة كـMale لـ
+
+487
+00:52:38,220 --> 00:52:44,180
+X-linked recessive genotype، لما نأخذها راح تكون
+
+488
+00:52:44,180 --> 00:52:47,920
+الـfrequency هي الـfrequency تبعت الـgenes في
+
+489
+00:52:47,920 --> 00:52:54,460
+الـpopulation 0.92% و0.08%، راح أشوف إشي زي ذلك
+
+490
+00:52:55,280 --> 00:53:04,500
+ماشي، فهذا مثال برضه على استخدام التعقيدات بالنسبة
+
+491
+00:53:04,500 --> 00:53:12,000
+للموضوع هذا، على افتراض أولاً إنه الـHardy
+
+492
+00:53:12,000 --> 00:53:17,960
+-Weinberg equation أو law، اللي هو بيفترض إن الـ
+
+493
+00:53:17,960 --> 00:53:22,360
+population stable، الـmutation مافيش إشي زديد
+
+494
+00:53:22,360 --> 00:53:28,110
+مافيش migration، الـmating مسموح بيه بين كل الأفراد
+
+495
+00:53:28,110 --> 00:53:37,470
+بشكل طبيعي، فيها أسئلة؟
+
+496
+00:53:37,470 --> 00:53:42,410
+الآن لما
+
+497
+00:53:42,410 --> 00:53:49,550
+نقول إن زي المشكلة قبل شوية، اللي هي أو الملاحظة
+
+498
+00:53:49,550 --> 00:53:54,960
+قبل شوية، اللي هو لما أخذنا الـColor Vision
+
+499
+00:53:54,960 --> 00:54:02,480
+Blindness، أو عمل ألوان، أو Normal Vision، ماشي؟ هذه
+
+500
+00:54:02,480 --> 00:54:09,940
+ظاهرة Very Frequently وموجودة، ولما بلاقيها موجودة
+
+501
+00:54:09,940 --> 00:54:18,620
+عند الناس، ماشي؟ بلاقيها كـ يعني على أساس إنه حتى
+
+502
+00:54:18,620 --> 00:54:23,620
+اللي عنده Color Blindness بإمكانه يتزاوج، وبإمكانه
+
+503
+00:54:23,620 --> 00:54:29,020
+يخلف، وما بتأثرش في حياته، وبقيش تقريباً حياة طبيعية
+
+504
+00:54:29,020 --> 00:54:34,040
+يعني بس شوية صعوبة أنه يفرق بين الأحمر والأخضر، ولا
+
+505
+00:54:34,040 --> 00:54:41,240
+بين اللونين ولا كذا ولا هيك، في أحياناً نتكلم على
+
+506
+00:54:41,240 --> 00:54:44,780
+الأمراض
+
+507
+00:54:44,780 --> 00:54:53,720
+اللي نتيجة المرض بيكون أنه الـجين هذا ما راح يكمل
+
+508
+00:54:53,720 --> 00:55:01,060
+يعني أنا بالنسبة لي هدول حاطين مجموعة أمراض شكل
+
+509
+00:55:01,060 --> 00:55:08,320
+معين، بس “Osteogenesis imperfecta” هذا مرض كان عندنا
+
+510
+00:55:08,320 --> 00:55:12,960
+و أنا كنت طالب طب في مستشفى مبارك في الكويت، كانت
+
+511
+00:55:12,960 --> 00:55:19,320
+مريضة مقيمة في المستشفى، عندها هشاشة شديدة جداً جداً
+
+512
+00:55:19,320 --> 00:55:26,350
+في العظام، يعني مجرد مرات تقح، بنكسر العظم، تشدها أو
+
+513
+00:55:26,350 --> 00:55:31,810
+تسلم عليها بيدك بقوة، بنكسر العظم، فعندها هشاشة
+
+514
+00:55:31,810 --> 00:55:36,730
+شديدة في العظام، المريضة كان يمكن عمرها 25 سنة
+
+515
+00:55:36,730 --> 00:55:44,190
+طبعاً الملاحظ إلها، إذا بتفرجيكم صور إلها لهذه
+
+516
+00:55:44,190 --> 00:55:49,750
+الحالة، Osteogenesis imperfecta، بتلاقي لون العيون
+
+517
+00:55:49,750 --> 00:55:57,740
+زرقاء، بياض العين، يعني خلينا نفرجيكم صورتها
+
+518
+00:55:57,740 --> 00:56:05,500
+أستيوجينيــــــــــــــــــــــ
+
+519
+00:56:42,760 --> 00:56:51,580
+فمريضتي، إذا شايفين الصورة هذه معاي، شايفينها هي
+
+520
+00:56:51,580 --> 00:56:56,890
+يمكن امرأة عمرها عشرين سنة، وخمسة وعشرين سنة على
+
+521
+00:56:56,890 --> 00:57:05,910
+wheelchair بهذا الشكل، وعظامها مكسورة، وكيبوسكوليوسيس
+
+522
+00:57:05,910 --> 00:57:12,290
+العظام بشكلها مش مظبوط، وبتكون بشكل تعبان كتير
+
+523
+00:57:12,290 --> 00:57:16,390
+فالفكرة اللي
+
+524
+00:57:24,470 --> 00:57:32,050
+الفكرة أنه لما يكون مرض بالمثل هذه الحالة، شو
+
+525
+00:57:32,050 --> 00:57:39,230
+إحتمالية؟ لو أنا عندي الـP والـQ، وعندي
+
+526
+00:57:39,230 --> 00:57:44,970
+نسب لهذه الجينات في المجتمع، ماشي، شو نسبتها
+
+527
+00:57:44,970 --> 00:57:49,430
+بالنسبة للمرض هذا؟ في حد بيقدر يقول لي؟
+
+528
+00:58:06,380 --> 00:58:15,160
+الـ، على افتراض أنه هذا الـ يعني النقطة اللي بده
+
+529
+00:58:15,160 --> 00:58:23,040
+يصلها في الموضوع هذا، اللي هي موضوع أن حدوث هذه
+
+530
+00:58:23,040 --> 00:58:29,760
+الطفرة بهذا الشكل، وتواجدها في الإنسان بيكون
+
+531
+00:58:29,760 --> 00:58:39,650
+أحياناً lethal type، يعني ويكون مميت، فالاستنتاج
+
+532
+00:58:39,650 --> 00:58:47,730
+من أن هذه الأمراض عبارة عن أمراض قاتلة، خصوصاً
+
+533
+00:58:47,730 --> 00:58:52,370
+أحياناً كثيرة، زي الـChromosome of anomalies، حتى
+
+534
+00:58:52,370 --> 00:58:56,290
+بالجنين، بالـembryo، كثير من الـlethal وما بيكملش
+
+535
+00:58:56,290 --> 00:59:02,790
+في الجنين، الأنواع من المشاكل هذه بالأخير راح تكون
+
+536
+00:59:03,280 --> 00:59:08,820
+كلها نتيجة طفرات جديدة عم تحدث في المجتمع، يعني
+
+537
+00:59:08,820 --> 00:59:16,540
+high disorders، لسبب إنه المصاب بهذه الحالة ما في
+
+538
+00:59:16,540 --> 00:59:21,780
+مجال إنه يتزوج، بحيث يعطي، ينقل هذا المرض للأبناء
+
+539
+00:59:21,780 --> 00:59:25,640
+والبنات تبعه، فالـfrequency اللي بنحكي عنها الـP
+
+540
+00:59:25,640 --> 00:59:33,280
+والـQ، والنسب هذه ما تنطبق هنا، والسبب إنهما في مجال
+
+541
+00:59:33,280 --> 00:59:40,020
+إن هاي الحالة تكون نتيجة طفرة من الأب والأم، لأن
+
+542
+00:59:40,020 --> 00:59:44,840
+ما في إنسان عنده هذا المرض وصل إنه يكون أب أو أم
+
+543
+00:59:44,840 --> 00:59:52,420
+يكون، يقدر يتزوج، أو حد يتزوجه، واضح؟ فأحياناً الـ
+
+544
+00:59:52,420 --> 01:00:01,140
+“هاي”، لما يعني القصة اللي بدرسوها بالنسبة للموضوع
+
+545
+01:00:01,140 --> 01:00:07,930
+هذا، اللي هو بيسموه الـfitness، اللي هو إنه هل هاي
+
+546
+01:00:07,930 --> 01:00:15,230
+الحالة، أو المرض، أو الشغل بتأثر على أهليته للزواج،
+
+547
+01:00:15,230 --> 01:00:20,170
+على رغبة البشر الآخرين إنه يتزوجوه، ويتزوجوا منه
+
+548
+01:00:20,170 --> 01:00:26,470
+أو يزوجوه، أو يتزوجها، فلما يكون في عندي condition
+
+549
+01:00:26,470 --> 01:00:33,570
+بـzero fitness، يعني ما في احتمالية إنه بعد إصابة
+
+550
+01:00:33,570 --> 01:00:39,050
+إنسان بهذا المرض، أو ولادته فيه، لأنه مرض وراثي ما
+
+551
+01:00:39,050 --> 01:00:44,950
+في احتمالية إن هذا يكون ناقل للمرض بعدين، لأن ما حدا
+
+552
+01:00:44,950 --> 01:00:53,810
+بيزوجوه بعدين، يعني فهذه ظاهرة أخرى لما نشوف مثل
+
+553
+01:00:53,810 --> 01:01:00,170
+هذه، نسبة احتمالية هذا المرض، فهو نسبة يعني معتمد
+
+554
+01:01:00,170 --> 01:01:07,630
+على نسبة تكوّن ونشوء new mutation، لأنه ما في مجال
+
+555
+01:01:07,630 --> 01:01:15,490
+أن يكون نتيجة transmission of الجين للأولاد
+
+556
+01:01:15,490 --> 01:01:24,050
+والبنات، لأنه lethal، لأنه ما بيكون ممكن أنه ينقل
+
+557
+01:01:24,050 --> 01:01:31,130
+الـCCR5 Delta اللي هو الـmutation هذه ما أثرت على
+
+558
+01:01:31,130 --> 01:01:36,590
+واحد، الـcolor blindness كمثال آخر بالـmales ولا
+
+559
+01:01:36,590 --> 01:01:42,310
+الـfemales، وكذا برضه مش مأثرة، الـblood group مش
+
+560
+01:01:42,310 --> 01:01:48,310
+مأثرة، يعني ما بتأثر على الـfitness تبع الإنسان
+
+561
+01:01:48,310 --> 01:01:59,590
+للزواج، ونقل الوراثات للأبناء والبنات بعد ذلك، يعني
+
+562
+01:02:00,870 --> 01:02:08,590
+التطبيق الآخر، في أسئلة؟
+
+563
+01:02:08,590 --> 01:02:15,330
+التطبيق
+
+564
+01:02:15,330 --> 01:02:19,170
+الآخر للمعلومات
+
+565
+01:02:19,170 --> 01:02:27,930
+هذه، اللي هي أنك أنت لما تدرس قد إيش، نسب، أي شيء
+
+566
+01:02:28,700 --> 01:02:33,640
+بتلاقي يعني
+
+567
+01:02:33,640 --> 01:02:42,000
+بتلاقي معلومات تكون مفيدة للطب، والمجتمع، وكيف ده
+
+568
+01:02:42,000 --> 01:02:48,300
+تتعامل مع الكثير من الأشياء، فالنقطة التالية
+
+569
+01:02:48,300 --> 01:02:55,900
+بالنسبة لك، مواضيع إنه حكينا عن الـP والـQ وكذا، بدأ
+
+570
+01:02:55,900 --> 01:03:02,780
+تكون في population معينة، تكون في مجموعة معينة
+
+571
+01:03:02,780 --> 01:03:09,260
+أحياناً، الصورة اللي أخذناها قبل شوية لـEuropa وكذا
+
+572
+01:03:09,260 --> 01:03:19,180
+على اعتبار أنه كل بشر في مكان معين، يعني ما فيش
+
+573
+01:03:19,180 --> 01:03:26,150
+هالـmigration كتير، كل واحد بيتزوجوا من بعض بخطوط
+
+574
+01:03:26,150 --> 01:03:32,110
+شوية، فيه نوع من الـisolation، وهي يعني غصب عنها
+
+575
+01:03:32,110 --> 01:03:38,750
+أحياناً بتحدث، يعني مثلًا في أمريكا مثلًا بيتكلموا
+
+576
+01:03:38,750 --> 01:03:42,730
+على إن الأمريكان السود، إيش إلهم؟ إيش الأمريكان
+
+577
+01:03:42,730 --> 01:03:48,050
+البيض؟ إلهم وراثة معينة؟ الأمريكان الأصليين
+
+578
+01:03:48,050 --> 01:03:54,380
+الهنود الحمر؟ إلهم إشي ثالث؟ يعني حتى على مستوى
+
+579
+01:03:54,380 --> 01:04:00,600
+مرات يعني أنا مثلاً في أي مكان، مثلاً في الأردن
+
+580
+01:04:00,600 --> 01:04:07,200
+نتلاقي مثلاً نتكلم: والله العيل الفلاني مثلاً
+
+581
+01:04:07,200 --> 01:04:12,400
+مافيش عندهم مثلاً، في مثلاً
+
+582
+01:04:12,400 --> 01:04:19,830
+في حالة اللي بيسموها حساسية من المواد المخدرة، تبع الـ
+
+583
+01:04:19,830 --> 01:04:26,450
+General Anesthesia، فالـGeneral Anesthesia Agents
+
+584
+01:04:26,450 --> 01:04:31,290
+أحياناً بتسبب حالة شديدة جداً جداً، وخطيرة جداً، ففي
+
+585
+01:04:31,290 --> 01:04:37,490
+عائلة معينة معروفين عنها في البلد، وفي بالذات يعني
+
+586
+01:04:37,490 --> 01:04:41,550
+في منطقتنا، وهؤلاء آه والله هذه العيلة عندهم الحالة
+
+587
+01:04:41,550 --> 01:04:46,530
+الفلانية، لما تعطيهم تخدير بدك تكون حذر جداً، وبدك
+
+588
+01:04:46,530 --> 01:04:51,250
+تأخذ احتياطات، وبدك تعمل كذا، أحياناً إنك تعرف إن الـ
+
+589
+01:04:51,250 --> 01:04:55,690
+population اللي أنت بتتعامل معها عندها حالة معينة
+
+590
+01:04:55,690 --> 01:05:01,870
+بيكون هذا قضية مهمة، فالآن نأخذ بعض الأمثلة لخمس
+
+591
+01:05:02,170 --> 01:05:13,210
+طفرات، أو خمس حالات، أو شو اسمه، بالنسبة لخمس أمراض
+
+592
+01:05:13,210 --> 01:05:20,170
+الأول اللي هو Sickle Cell Anemia، الـSS Genotype
+
+593
+01:05:20,170 --> 01:05:27,330
+يعني خلل، أو وجود مرض Sickle Cell بالنسبة
+
+594
+01:05:27,330 --> 01:05:37,610
+لهنا حاطين، الـبالنسبة للـAfrican Americans
+
+595
+01:05:37,610 --> 01:05:44,570
+الأفارقة الأمريكان، الأفارقة من أصول أفريقية، الـSS
+
+596
+01:05:44,570 --> 01:05:52,510
+Hemoglobin، تقريباً نسبته واحد في كل 400 شخص، هذه
+
+597
+01:05:52,510 --> 01:05:59,770
+النسبة، ماشي، وعندما تيجي تأكسها، يعني هي تمثل الـ
+
+598
+01:05:59,770 --> 01:06:07,680
+الـ الـQ تربيع، فالـ هو أنا عشرين من عشرين يعني
+
+599
+01:06:07,680 --> 01:06:16,620
+واحد من العشرين، من كل العشرين أمريكي
+
+600
+01:06:16,620 --> 01:06:22,240
+أفريقي من أصول أفريقية اللي عنده الـSickle Cell
+
+601
+01:06:22,240 --> 01:06:27,340
+Trait، أو القليل، فواحد من عشرين تطلع خمس بالمئة
+
+602
+01:06:27,340 --> 01:06:35,860
+فالـQ خمس بالمئة، وعشان هيك بيطلع واحد في اللي هو
+
+603
+01:06:35,860 --> 01:06:43,420
+من كل 400، بس من ناحية ثانية، كم نسبة الـ
+
+604
+01:06:43,420 --> 01:06:52,160
+carriers لهذا الجين اللي هو 5%؟ راح تكون 2PQ، في 95
+
+605
+01:06:52,160 --> 01:07:01,750
+% راح تطلع تقريباً 0.9، اللي هي راح تطلع واحد كل
+
+606
+01:07:01,750 --> 01:07:09,590
+أحد عشر، هذه النسبة على إذا أخذنا الـsteady state
+
+607
+01:07:09,590 --> 01:07:17,670
+الـHardy-Weinberg Equation، بنسبة نسبة حدوث المرض
+
+608
+01:07:17,670 --> 01:07:25,490
+ونسبة القليل، الصورة
+
+609
+01:07:25,490 --> 01:07:30,670
+الموجودة، أو الـgene الموجود، وشو نسبة حدوثه، وشو
+
+610
+01:07:30,670 --> 01:07:37,870
+نسبة اللي هي الـheterozygous، يعني اللي عندهم نسبة
+
+611
+01:07:37,870 --> 01:07:44,130
+الـcarrier، يعني هو لنا بدا تكون اللي هم الواحد في
+
+612
+01:07:44,130 --> 01:07:51,910
+الـ11، بينما لمنطقة قريبة، أو لمجموعة قريبة في
+
+613
+01:07:51,910 --> 01:07:58,650
+أمريكا، اللي هم الـHispanics من أصول أسبانية، ومن
+
+614
+01:07:58,650 --> 01:08:07,610
+أصول يعني مختلفة، من مش أفريقيا، مش أفارقة، النسبة
+
+615
+01:08:07,610 --> 01:08:14,45
+
+667
+01:13:27,960 --> 01:13:33,770
+Recessive Disorders وبتكون يعني الـ Q تربيع هي
+
+668
+01:13:33,770 --> 01:13:39,010
+نسبة الحدوث للـ Disease لأن هذا اللي بدي يكون عنده
+
+669
+01:13:39,010 --> 01:13:46,050
+Two copies which are يعني effective بالنسبة
+
+670
+01:13:46,050 --> 01:13:49,170
+لبعض الـ Other diseases زي الـ «فاميليال
+
+671
+01:13:49,170 --> 01:13:53,810
+الهيبركوليستروليميا» و «myotonic dystrophy» الـ
+
+672
+01:13:53,810 --> 01:13:56,090
+«myotonic dystrophy»، «فاميليال الهيبركوليستروليميا»
+
+673
+01:13:56,090 --> 01:13:59,890
+واحد من هذه الـ hyperlipidemias وهذه الأرقام
+
+674
+01:13:59,890 --> 01:14:08,570
+عندكم والـ Myotonic Dystrophy اللي هو تشنج العضلات
+
+675
+01:14:08,570 --> 01:14:14,710
+ويكون خلل في العضلات تظلها مضطرة يعني ما فيش
+
+676
+01:14:14,710 --> 01:14:21,090
+relaxation للعضلة النقطة وما فيها أنه اللي راح
+
+677
+01:14:21,090 --> 01:14:26,770
+أشوفه من عنده disease ماشي من هذا النوع لأن هذا
+
+678
+01:14:26,770 --> 01:14:35,280
+صفة سائدة فهوالـ Q تربيع نسبة الأليل المصاب
+
+679
+01:14:35,280 --> 01:14:40,180
+ونسبة الـ heterozygous مع بعض يعني هذه الـ
+
+680
+01:14:40,180 --> 01:14:48,220
+frequency اللي راح أشوفها تتمثل هذه الاحتمالية
+
+681
+01:14:48,220 --> 01:14:54,320
+فأنا لما أشوف مثلاً واحد في كل 25 ألف أو واحد في كل
+
+682
+01:14:54,320 --> 01:14:57,970
+500 تقريباً ولا بالنسبة لـ Family of
+
+683
+01:14:57,970 --> 01:15:04,250
+Hypercholesterolemia واحد في السبعين في أفريقيا أو
+
+684
+01:15:04,250 --> 01:15:08,270
+في أمريكا واحد في الخمسمائة أو في كينيا واحد في
+
+685
+01:15:08,270 --> 01:15:18,330
+الـ 122 فهذه النسب المتوقعة للأليل تبع الـ Disease
+
+686
+01:15:18,330 --> 01:15:27,720
+تكون بهذا الشكل فيعني الطبيب يعني أحياناً لما واحد
+
+687
+01:15:27,720 --> 01:15:32,020
+يتعامل مع الطب في population معينة بهمه يعرف إذا
+
+688
+01:15:32,020 --> 01:15:37,300
+فيه مميز لهم إذا فيه احتمالية أكبر لبعض الأمراض
+
+689
+01:15:37,300 --> 01:15:45,560
+أكثر من أمراض ثانية والأصل وزارة الصحة والمسح
+
+690
+01:15:45,560 --> 01:15:53,720
+الطبي والمسح الصحي في منطقة معينة أنه يكون على
+
+691
+01:15:53,720 --> 01:16:02,300
+انتباه لهذه الأمراض ونسبها ويكون يعني تصور لوجودها
+
+692
+01:16:02,300 --> 01:16:08,120
+وبالتالي يعني بيخلي القطاع الصحي منتبه أكثر لشغل
+
+693
+01:16:08,120 --> 01:16:11,820
+عمله طريقة
+
+694
+01:16:11,820 --> 01:16:18,900
+يعني استفادة أخرى من هذا الموضوع هي قضية
+
+695
+01:16:21,530 --> 01:16:30,790
+في أسئلة على اللي تمّ من قبل؟ في أي استفسار؟
+
+696
+01:16:30,790 --> 01:16:39,230
+أموركم كويسة؟
+
+697
+01:16:39,230 --> 01:16:41,250
+طيب، نكمل
+
+698
+01:16:45,000 --> 01:16:53,100
+في سؤال من كريم بيقول الأرقام والنسب مش حفظ يعني
+
+699
+01:16:53,100 --> 01:16:58,060
+مطلوب فاهم كيف أجت وشو نفهم منها بس طبعاً، طبعاً،
+
+700
+01:16:58,060 --> 01:17:04,480
+طبعاً، ويعني النقطة الحقيقية المطلوبة من هذه
+
+701
+01:17:04,480 --> 01:17:09,550
+الأرقام قضية تفاوتها في نفس المجتمع يعني في المجتمع
+
+702
+01:17:09,550 --> 01:17:14,930
+الأمريكي والله نسبة الـ Sickle Cell لو كان إنسان
+
+703
+01:17:14,930 --> 01:17:20,130
+أبيض أو أسود أو أمريكي أصلي أو كذا كيف إنها أو
+
+704
+01:17:20,130 --> 01:17:28,390
+Hispanic population هذه ناحية مهمة وهذه بالنسبة
+
+705
+01:17:28,390 --> 01:17:37,310
+لهم ماشية يعني أحياناً إليها دخل بنسميه بالطب
+
+706
+01:17:37,310 --> 01:17:43,910
+الشخصي Personalized Medicine بصير أنا هنا من
+
+707
+01:17:43,910 --> 01:17:50,290
+المعلومات السابقة عن نسبة حدوث المرض الفلاني في
+
+708
+01:17:50,290 --> 01:17:56,010
+المجموعة الفلانية بتخليني أتنبأ أو أعرف جزء من
+
+709
+01:17:56,420 --> 01:18:01,280
+سواء نوعية المرض اللي عنده شدة المرض اللي عنده
+
+710
+01:18:01,280 --> 01:18:05,200
+احتمالية المرض اللي عنده فهذه أحياناً معلومات
+
+711
+01:18:05,200 --> 01:18:08,920
+مفيدة جداً وأحياناً تستخدم حتى على مستوى الشخص
+
+712
+01:18:08,920 --> 01:18:15,260
+ماشي أنه إيش يعني في أمريكا مثلاً من الأشياء اللي
+
+713
+01:18:15,260 --> 01:18:21,380
+دائماً بيسألوا عنها ويعني بيركزوا عليها قضية شو
+
+714
+01:18:21,380 --> 01:18:27,090
+أصولها قوقازي يعني أبيض، إحنا طبعاً البيض، العرب
+
+715
+01:18:27,090 --> 01:18:32,030
+بيعتبرونا قوقازيين يعني لما نأخذ التصنيف، بس مش
+
+716
+01:18:32,030 --> 01:18:40,130
+أفريقي، مش هسباني أو إسباني، يعني مش طبعاً أصول
+
+717
+01:18:40,130 --> 01:18:46,610
+الصينية، Orientals، أصول هندية، مثلاً، بدك تشوف في
+
+718
+01:18:46,610 --> 01:18:53,240
+أي ناحية أحياناً مهمة في قضية توقعك للمرض ماشي
+
+719
+01:18:53,240 --> 01:19:00,740
+دائماً الأرقام ما هي يعني المهم فهم العلاقات بينها
+
+720
+01:19:00,740 --> 01:19:06,680
+وليش هي أجت وشو بتمثل ماشي أكثر من إنه شو هو الرقم
+
+721
+01:19:06,680 --> 01:19:18,920
+نفسه يعني إذا أنا أعطيتك مثلاً disease recessive
+
+722
+01:19:18,920 --> 01:19:24,550
+وأعطيتك مثلاً إنه بيصير واحد من عشرة من
+
+723
+01:19:24,550 --> 01:19:31,850
+الـ population تقدر تجيب الـ Q إذا واحد من العشرة
+
+724
+01:19:31,850 --> 01:19:36,670
+من ال population عنده الـ disease، ماشي؟ فإذا
+
+725
+01:19:36,670 --> 01:19:38,470
+العشرة هو
+
+726
+01:19:38,470 --> 01:19:45,730
+اللي…
+
+727
+01:19:49,770 --> 01:19:59,310
+هنا لما يكون مثلاً 1 في الأربعمئة معناته لو أخذناها
+
+728
+01:19:59,310 --> 01:20:06,290
+نسبة راح تطلع 1 بالعشرين ماشي لأنه الـ 1 في
+
+729
+01:20:06,290 --> 01:20:11,290
+العشرين إذا نسبة الأليل في الـ population بيخليني
+
+730
+01:20:11,290 --> 01:20:16,290
+إن المصابين 1 بالأربعمئة نسبة الـ carriers إذا 0
+
+731
+01:20:16,290 --> 01:20:26,260
+.05% اللي هي راح تطلع كنسبة Carrier 0.1 اللي هي 2PQ
+
+732
+01:20:26,260 --> 01:20:32,480
+ماشي، لما أضرب بعض النسب المفروض أطلق أرقام زي
+
+733
+01:20:32,480 --> 01:20:38,720
+هذه أظن يعني مش غلط أنه جدول زي هيك الواحد يقعد
+
+734
+01:20:38,720 --> 01:20:44,230
+يطلع مثلاً شو نسبة الـ P مثلاً لو هيك نأخذها exercise
+
+735
+01:20:44,230 --> 01:20:49,190
+بعدين ونطلق نسبة الـ P تبعت الـ population تبعت
+
+736
+01:20:49,190 --> 01:20:53,330
+الأليل الأصلي أو اللي هو اللي مش مصاب دكتور في
+
+737
+01:20:53,330 --> 01:20:59,110
+سؤال سؤالين حتى في سؤال من معتز بيسأل كيف الـ
+
+738
+01:20:59,110 --> 01:21:02,910
+carrier أجى يعني P كم نسبة يعني كيف الـ carrier أجى
+
+739
+01:21:02,910 --> 01:21:07,670
+يعني بيسأل P كانت كم نسبتها مش مكتوب مش عارف إذا
+
+740
+01:21:07,670 --> 01:21:14,830
+كان موجوده على الـ slide السابق اسمعني، الآن
+
+741
+01:21:14,830 --> 01:21:22,710
+لما تيجي تأخذ أنت القاعدة الأولى بالنسبة للـ
+
+742
+01:21:22,710 --> 01:21:32,870
+equation ماشي أن الـ P زائد الـ Q يساوي كم؟ يساوي واحد
+
+743
+01:21:32,870 --> 01:21:42,220
+فهمت عليّ إيه؟أنت لما تيجي تأخذ لك 100 بني آدم كم
+
+744
+01:21:42,220 --> 01:21:49,700
+نسخة من الجين راح تلاقي؟ راح تلاقي عندي 200 نسخة،
+
+745
+01:21:49,700 --> 01:21:56,340
+صح؟ فأنا عندي 200 نسخة من الجين اللي هو زي CCR
+
+746
+01:21:56,340 --> 01:22:02,420
+سواء الـ 5 الأصلي أو الـ Mutated نفترض هيك،
+
+747
+01:22:02,420 --> 01:22:11,350
+صح؟ فلما أنا عندي 200 نسخة أخذتها من 100 إنسان ماشي،
+
+748
+01:22:11,350 --> 01:22:19,370
+نسبة هذا الـ Disease أو الـ Normal هذول النسبتين
+
+749
+01:22:19,370 --> 01:22:25,370
+مجموعهم 100 أو 1 آسف، راح يكون مجموعهم 1 فلما أنا
+
+750
+01:22:25,370 --> 01:22:29,190
+أخذ إن الـ P، الـ Q هنا صفر مثلاً زي الـ Sickle
+
+751
+01:22:29,190 --> 01:22:35,880
+Cell في الـ African Americans النتيجة هي 0.05 هذا
+
+752
+01:22:35,880 --> 01:22:40,240
+أليل frequency هذا على مستوى الـ gene لما أنا درست
+
+753
+01:22:40,240 --> 01:22:48,920
+الـ 200 حالة اللي أنا قدرت أدرسهم فنتيجة الأمر هذا
+
+754
+01:22:48,920 --> 01:22:58,980
+راح يكون إنه ظاهرياً كإنسان عنده مرض لهذه الحالة
+
+755
+01:22:58,980 --> 01:23:04,450
+زي في الـ African American هو واحد في الأربعمئة اللي
+
+756
+01:23:04,450 --> 01:23:11,210
+هو بدك تحسبها وتشوف راح تطلع 0.0025 اللي هي واحد
+
+757
+01:23:11,210 --> 01:23:16,950
+في الأربعمئة تضرب الـ Q تربيع ناشط اللي هي الواحد
+
+758
+01:23:16,950 --> 01:23:22,330
+على الأربعمئة شو نسبة الـ Carriers؟ واحد من عشرة
+
+759
+01:23:22,330 --> 01:23:29,350
+تقريباً اللي هو راح تطلع 0.1 percent فالـ
+
+760
+01:23:30,120 --> 01:23:36,600
+الـ P و الـ Q نتكلم على نسبة الأليل في دراسة أنت
+
+761
+01:23:36,600 --> 01:23:42,400
+تأخذ كل إنسان عنده اثنين وأنا ما بعرف هو
+
+762
+01:23:42,400 --> 01:23:48,400
+الإنسان اللي أمامي هو Pure Capital A Capital A ولا
+
+763
+01:23:48,400 --> 01:23:52,600
+Capital A Small A ولا Small A Small A أنا لسه ما
+
+764
+01:23:52,600 --> 01:23:58,810
+بعرف بس كمجموع Capital A و Small A مجموعهم راح يكون
+
+765
+01:23:58,810 --> 01:24:04,190
+الـ Frequency 1 واضح؟ في أسماء برضه يعني بتسأل عن
+
+766
+01:24:04,190 --> 01:24:07,750
+قضية الـ Q تربيع مش عارف إيه بتسأل بتقول يعني كيف
+
+767
+01:24:07,750 --> 01:24:11,170
+كيف الـ Q تربيع كيف جاب النسبة تبعها لأنها مش
+
+768
+01:24:11,170 --> 01:24:16,370
+جواب Q ضرب Q لأ ليش مش جواب؟ مش عارف أنا أستغرب من
+
+769
+01:24:16,370 --> 01:24:21,650
+السؤال اللي أمامي لأ لأ أنت احسبيها 1 على 400 رح
+
+770
+01:24:21,650 --> 01:24:30,850
+تطلع 0.0025 واضربيها ماشي راح تعطيكي شو اسمه الـ Q
+
+771
+01:24:30,850 --> 01:24:38,030
+تربيع ماشي الأرقام اللي قدامكم اشتغلوا عليها الـ 1
+
+772
+01:24:38,030 --> 01:24:43,610
+على 400 حوليها لكسر يعني حوليها لـ 0.0025 راح
+
+773
+01:24:43,610 --> 01:24:48,690
+تلاقي كيف تيجي ماشي رياضياً الأرقام مظبوطة اللي
+
+774
+01:24:48,690 --> 01:24:54,790
+قدامكم 100% يعني بس بدأ الواحد يفهم معنا شو الـ Q
+
+775
+01:24:54,790 --> 01:24:59,530
+شو الـ P و ليش الـ heterozygous يعني اللي هو الـ
+
+776
+01:24:59,530 --> 01:25:06,750
+carrier percentage بهذا الشكل، آه فلس تمام، أعتقد
+
+777
+01:25:06,750 --> 01:25:09,590
+الأمور واضحة بالنسبة للأشخاص اللي سألوا يعني هنا
+
+778
+01:25:09,590 --> 01:25:13,490
+ننتبه إنه لما نكون dominant إذا أنا عارف إنه
+
+779
+01:25:13,490 --> 01:25:18,750
+dominant الـ incidence للـ disease هي الـ Q تربيع
+
+780
+01:25:18,750 --> 01:25:25,720
+زي الـ 2PQ، هذه نسبة مجموعة اثنين، ماشي؟ وإذا أنا
+
+781
+01:25:25,720 --> 01:25:31,900
+بقدر يعني تعطيني أي رقم لـ Incidence of an allele
+
+782
+01:25:31,900 --> 01:25:37,660
+أو mutation راح تلاقي، راح تكون هذه النسب صحيحة أو
+
+783
+01:25:37,660 --> 01:25:43,800
+مظبوطة يعني طيب، إذا خلصنا السؤال، الآن نجي على
+
+784
+01:25:43,800 --> 01:25:52,390
+موضوع آخر استفادة من هذه الجوانب يعني بالذات الأمر
+
+785
+01:25:52,390 --> 01:25:57,050
+في أمور الـ Genetics أحياناً مربوط بالدول المتقدمة
+
+786
+01:25:57,050 --> 01:26:04,990
+حضارياً ومادياً وصحياً وطبياً بتلاقي يعني فيه
+
+787
+01:26:04,990 --> 01:26:09,330
+جوانب نتكلم
+
+788
+01:26:09,330 --> 01:26:17,970
+عن يعني حقيقةً هي تقدم تقني في إمكانية عمل فحوصات
+
+789
+01:26:21,730 --> 01:26:28,770
+من أنواع الفحوصات هي طريقة يعني أنا كنت مرة ذكرت
+
+790
+01:26:28,770 --> 01:26:32,850
+معلومة من قبل فيه دراسات لما درسوا الـ
+
+791
+01:26:32,850 --> 01:26:38,930
+Mitochondrial Inheritance و Mitochondrial Diseases
+
+792
+01:26:38,930 --> 01:26:44,990
+أو Mitochondrial DNA لقينا طبعاً الـ mitochondrial
+
+793
+01:26:44,990 --> 01:26:49,690
+DNA لا ينتقل إلا عن طريق الأم الأب ما له دخل ومن
+
+794
+01:26:49,690 --> 01:26:54,970
+مصدر واحد يعني فقط عن طريق الأم في البويضة بتنتقل
+
+795
+01:26:54,970 --> 01:26:58,530
+الـ mitochondrial chromosome و الـ mitochondrial
+
+796
+01:26:58,530 --> 01:27:09,340
+DNA فنتيجة لما تيجي أنت تدرس يكون عندك آلة تقدر
+
+797
+01:27:09,340 --> 01:27:17,400
+تعمل نوع من الـ Genetic Testing سواء باستخدام يعني
+
+798
+01:27:17,400 --> 01:27:27,460
+طبعاً باستخدام الـ PCR باستخدام الـ … باستخدام أنه
+
+799
+01:27:27,460 --> 01:27:32,040
+عن طريق Enzymes بتقطع الـ DNA في أماكن معينة
+
+800
+01:27:34,990 --> 01:27:46,530
+فبيسموها يعني أنواع من الـ يعني من الآلات ماشي
+
+801
+01:27:46,530 --> 01:27:50,030
+تقدر
+
+802
+01:27:50,500 --> 01:27:55,180
+يعني بالنسبة للـ Mitochondrial DNA في الأخير،
+
+803
+01:27:55,180 --> 01:28:00,940
+النتيجة اللي وصلوا لها إنه قدروا يثبتوا أو يشوفوا إنه
+
+804
+01:28:00,940 --> 01:28:06,800
+في الأخير كل البشر يرجعون لـ 7 أمهات إنه كل البشر
+
+805
+01:28:06,800 --> 01:28:12,700
+إنه سبع أنواع من الـ Mitochondrial DNA أو
+
+806
+01:28:12,700 --> 01:28:18,180
+Mitochondrial Chromosomes وهذه السبعة أنواع محفوظين
+
+807
+01:28:18,180 --> 01:28:26,750
+فيها إحنا و أنه بالأخير يعني بتدعوا أنه بنرجع
+
+808
+01:28:26,750 --> 01:28:33,210
+بالأخير لسبع إناث كانوا هم مصدر البشرية كلها
+
+809
+01:28:33,210 --> 01:28:36,750
+أحياناً
+
+810
+01:28:36,750 --> 01:28:43,730
+يعني كناحية وراثية بس أهم من هيك أنه الـ
+
+811
+01:28:47,150 --> 01:28:57,710
+إذا عندي أنا آليات، أجهزة، إمكانات في يعني في
+
+812
+01:28:57,710 --> 01:29:00,790
+الولايات المتحدة الأمريكية أو بريطانيا أو أوروبا
+
+813
+01:29:00,790 --> 01:29:09,010
+أحياناً بيصير الواحد يقول أنا بدي أفهم أنا شو
+
+814
+01:29:09,010 --> 01:29:15,530
+أصولي يعني في أمريكا لحظة معينة يعني في التاريخ
+
+815
+01:29:15,530 --> 01:29:24,620
+العبودية كان عندهم إنه الأسود هو اللي نسبة السواد
+
+816
+01:29:24,620 --> 01:29:31,880
+فيه أكثر من واحد في ستة عشر واحد من ستة عشر يعني إذا
+
+817
+01:29:31,880 --> 01:29:41,720
+أبوه أسود أو أمه سوداء فنسبة السواد فيه نصف أو واحد
+
+818
+01:29:41,720 --> 01:29:49,670
+على اثنين إذا جدوده إذا الربع
+
+819
+01:29:49,670 --> 01:29:56,270
+يعني هم أربعة إذا واحد أسود بيظلوا بيعتبروه أسود
+
+820
+01:29:56,270 --> 01:30:03,410
+إذا واحد أبو جدوده واحد أسود مش مشكلة ما
+
+821
+01:30:03,410 --> 01:30:08,570
+بيعتبروه أسود طبعاً في الحالة هذه بيكون أقل من
+
+822
+01:30:08,570 --> 01:30:16,160
+واحد من ثمانية ماشي؟ فطلعت شغلة إنه إحنا من وين
+
+823
+01:30:16,160 --> 01:30:21,820
+جئنا وشو نسبة الـ .. يعني .. يعني ده الواحد بتطلع
+
+824
+01:30:21,820 --> 01:30:25,000
+على .. لما بيكونوا يتطلعوا على وجه الناس و خلقنا
+
+825
+01:30:25,000 --> 01:30:29,840
+ربنا و خلقنا كويسين بتلاقي مثلاً في أمريكا السود اللي
+
+826
+01:30:29,840 --> 01:30:33,060
+من أمريكا .. في أمريكا نفسهم اللي انتهى وجاء أسود
+
+827
+01:30:33,060 --> 01:30:38,060
+بتلاقي سواده شديد وشكله بشكل معين السود اللي في
+
+828
+01:30:38,060 --> 01:30:41,650
+أمريكا والله فيه نسبة كبيرة منهم بتقول عنه أنا عارف
+
+829
+01:30:41,650 --> 01:30:49,010
+هذا مختلط يعني إذا نائبة المرشح بايدن تبع أمريكا
+
+830
+01:30:49,010 --> 01:30:55,010
+بالانتخابات بتلاقيها يعني هي تقريباً بيضاء يعني مش
+
+831
+01:30:55,010 --> 01:31:02,110
+سوداء كثيراً كثيراً كثيراً بس مش بيضاء يعني على نفس الخطة
+
+832
+01:31:02,110 --> 01:31:08,530
+في الأدوات
+
+833
+01:31:09,240 --> 01:31:16,700
+في نفس الـ … يعني نسميها
+
+834
+01:31:16,700 --> 01:31:23,800
+أدوات أو فحوصات بتبين ليه لما إحنا نتكلم وندور
+
+835
+01:31:23,800 --> 01:31:30,680
+على ancestry informative markers يعني على مؤشرات
+
+836
+01:31:30,680 --> 01:31:37,050
+معينة حاولوا من خلال دراسات من قبل جابوا أبيض أبيض
+
+837
+01:31:37,050 --> 01:31:42,650
+مظبوط و Pure من كذا generation عرقية و أسود Pure من
+
+838
+01:31:42,650 --> 01:31:47,870
+كذا generation و Hispanic و أجواء درسوا الموضوع هذا
+
+839
+01:31:47,870 --> 01:31:52,510
+لقينا إنه مثلاً في البيض
+
+840
+01:31:55,620 --> 
+
+889
+01:37:12,990 --> 01:37:21,030
+مثلًا الله يوفقهم السوريين، ماشي؟ وإحنا مثلًا
+
+890
+01:37:21,030 --> 01:37:27,390
+الأصل إحنا مثلًا مليونينا، ربع مليون سوري
+
+891
+01:37:27,390 --> 01:37:33,670
+فجأة، مرة واحدة وأنا أدرس احتمالية حدوث الجينات
+
+892
+01:37:33,670 --> 01:37:40,110
+الهجرة هذه، ممكن تغير نسب الجينات بحيث إن الأرقام
+
+893
+01:37:40,110 --> 01:37:45,770
+اللي عندي قد لا تكون سليمة، وأحيانًا هذا موضوع مؤثر
+
+894
+01:37:45,770 --> 01:37:50,150
+يعني الـ population بالذات، إذا بيصير فيها
+
+895
+01:37:50,150 --> 01:37:56,830
+isolation، يعني مثلًا في أمريكا، إذا بتسمع مجموعة
+
+896
+01:37:56,830 --> 01:38:00,490
+اللي بيسموهم الـ Amish أو الـ "مارموند" أو الـ
+
+897
+01:38:00,490 --> 01:38:07,510
+يعني هدول مجموعات، هدول مثلًا في أمريكا صحيح، بس
+
+898
+01:38:07,510 --> 01:38:14,130
+هدول من أصول يعني زي، يعني بضربها مثل: إذا بتروح
+
+899
+01:38:14,130 --> 01:38:20,350
+على سوريا أو لبنان، بتلاقي المخيمات للفلسطينيين
+
+900
+01:38:20,350 --> 01:38:27,640
+بقول لك المنطقة الفلانية اللي هاجروا منها، صفر المنطقة
+
+901
+01:38:27,640 --> 01:38:31,040
+الفلانية اللي هاجروا من الناصرة، المنطقة
+
+902
+01:38:31,040 --> 01:38:35,980
+الفلانية اللي هاجروا منها، يعني حتى مثلًا لغزة، فلما
+
+903
+01:38:35,980 --> 01:38:41,180
+انتقلت نوع من الـ migration، بيغير، يعني ممكن إذا
+
+904
+01:38:41,180 --> 01:38:46,120
+صار تزاوج بس في منطقة معينة، يعني هدول اللي بحكي
+
+905
+01:38:46,120 --> 01:38:51,160
+عنهم، الـ Mormons أو الـ Amish في أمريكا، إذا تدخل على
+
+906
+01:38:51,160 --> 01:38:57,510
+هيك تشوف صورهم، بتميزهم، يعني عبارة عن ناس من
+
+907
+01:38:57,510 --> 01:39:03,810
+ألمانيا، شبيهين جدًا بالألمان كشكل، ولأن كثقافة
+
+908
+01:39:03,810 --> 01:39:10,710
+وبتزوجوا إلا من بعض، وبخلفوا كثير، فبتلاقي أنت هنا
+
+909
+01:39:10,710 --> 01:39:14,750
+الـ population هذه، أحيانًا بعض الـ diseases
+
+910
+01:39:14,750 --> 01:39:19,810
+بتلاقيها نسبتها أعلى بكثير، بسبب اللي بيسمونه
+
+911
+01:39:19,810 --> 01:39:24,700
+Founder Effect، يعني إنه اللي بدأ هذه الـ Population
+
+912
+01:39:24,700 --> 01:39:31,420
+يعني مثلًا، تتوقع مثلًا جزيرة، سفينة اتحطمت على
+
+913
+01:39:31,420 --> 01:39:38,180
+الجزيرة هذه، فيها مثلًا عشرين رجل، ومرة تيجي بعد
+
+914
+01:39:38,180 --> 01:39:42,920
+200 سنة، والجزيرة هذه معزولة، شو اللي راح يصير؟
+
+915
+01:39:42,920 --> 01:39:48,840
+بسبب إنه بدأت هذه من مجموعة قليلة، وما صارش عليهم
+
+916
+01:39:48,840 --> 01:39:54,730
+هجرة، وما تغيرتش، فبتلاقي النسب مختلفة عن غيرها، هذا
+
+917
+01:39:54,730 --> 01:40:02,270
+المقصود، وقضية الهجرة من ناحية مؤثرة على نسب الـ P
+
+918
+01:40:02,270 --> 01:40:12,130
+و الـ Q، راح تتأثر، شو موجودة، لأنه هنا… يعني
+
+919
+01:40:12,130 --> 01:40:19,450
+هنا صار حدث معين بطريقة معينة، اللي هو أنه بداية الـ
+
+920
+01:40:19,450 --> 01:40:25,910
+population هذه كانت عندهم gene معين، شكل معين، نسبته
+
+921
+01:40:25,910 --> 01:40:31,270
+أكثر، واحد، اثنين أو غيرهم مصابين، فبالتالي ضلّوا
+
+922
+01:40:31,270 --> 01:40:35,750
+ظاهر، وبالتالي يعني الـ… الـ… الـ frequency تبعته
+
+923
+01:40:35,750 --> 01:40:39,730
+أعلى بكثير، المعادلات اللي بنحكيها على هذه
+
+924
+01:40:39,730 --> 01:40:44,510
+الافتراضات اللي هي إنه الـ P و الـ Q لما نعتبرها
+
+925
+01:40:44,510 --> 01:40:50,020
+بهذا، بس يعني مثلًا لما تتكلم عن نقص في أمريكا، هي عندي
+
+926
+01:40:50,020 --> 01:40:56,540
+الـ Whites أو الـ Europeans أو الـ Caucasians، وفيه
+
+927
+01:40:56,540 --> 01:41:00,220
+الـ Blacks، وفيه الـ Hispanics، ودرجة الاختلاف هذه
+
+928
+01:41:00,220 --> 01:41:06,780
+طبعًا راح تتأثر إذا في تزاوج أو ما فيش تزاوج، وكم
+
+929
+01:41:06,780 --> 01:41:13,180
+نسبة اللي بتزاوجوا من بين الـ races اللي هي يعني
+
+930
+01:41:13,180 --> 01:41:20,230
+العروق البشرية، ماشي؟ الصينيين، الأفارقة، الأوروبيين،
+
+931
+01:41:20,230 --> 01:41:24,570
+القوقازيين، يعني بدك تأخذها بعين الاعتبار، في سؤال؟
+
+932
+01:41:24,570 --> 01:41:31,270
+واضح إن شاء الله، القضية، الله يعافيكم، ونشوفكم يوم
+
+933
+01:41:31,270 --> 01:41:34,970
+الاثنين إن شاء الله، وأجهزوا للامتحان، الله يعافيكم
+
+934
+01:41:34,970 --> 01:41:37,990
+الله
+
+935
+01:41:37,990 --> 01:41:41,470
+يعافيكم يا دكتور، الله يعافيكم، أهلا وسهلا، والسلام
+
+936
+01:41:41,470 --> 01:41:41,790
+عليكم
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/vL1zB0LyhmE_postprocess.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/vL1zB0LyhmE_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..dbff54ae38f550976e2975e5823109284d2ff37c
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/vL1zB0LyhmE_postprocess.srt
@@ -0,0 +1,3745 @@
+1
+00:00:00,000 --> 00:00:05,780
+في عرض السؤال يُذكر
+
+2
+00:00:05,780 --> 00:00:11,960
+إنه مش فاهم الصورة هذه نعود
+
+3
+00:00:11,960 --> 00:00:17,360
+مرة ثانية بالكاميرا دكتور إذا في ممكنية بستعمل
+
+4
+00:00:17,360 --> 00:00:26,360
+مشاركة للشاشة برضه؟ آه، آه، طيب خلّيني بس أتأكد،
+
+5
+00:00:26,360 --> 00:00:28,200
+سأعمل
+
+6
+00:00:33,660 --> 00:00:50,060
+خلّيني أيضًا أتأكد من بعث هذا الفيديو ‏-719،
+
+7
+00:00:50,060 --> 00:00:56,180
+ليس الصورة هذه ‏-
+
+8
+00:01:06,510 --> 00:01:13,290
+ماشي، حسّا، شو اللي بنقدر نقوله عن القصة بالنسبة
+
+9
+00:01:13,290 --> 00:01:21,890
+لسؤال زميلكم؟ بيسألني،
+
+10
+00:01:21,890 --> 00:01:25,150
+ممكن لو سمحت ما عرفت الـGenotype لكل من الزوج
+
+11
+00:01:25,150 --> 00:01:30,150
+والزوجة في هذه الحالة بالنسبة
+
+12
+00:01:30,150 --> 00:01:39,790
+للسؤال هذايعني الأهم إن الواحد يكون
+
+13
+00:01:39,790 --> 00:01:43,950
+قادر يقرأ الـ Pedigree هذه أو الشجرة العالية هذه
+
+14
+00:01:43,950 --> 00:01:48,650
+بطريقة سليمة يعني زوج وزوجي، أنا زوج وزوجي، يعني
+
+15
+00:01:48,650 --> 00:01:59,250
+فيه بالـ اللي هم الجيل الأول الأب
+
+16
+00:01:59,250 --> 00:02:04,290
+والأم اللي هم أبوا الـ يعنيأبو الجدود اللي هم اللي
+
+17
+00:02:04,290 --> 00:02:09,350
+فوق زي ما انت حطيت هنا لما نحط أزرق معناماته مصاب
+
+18
+00:02:09,350 --> 00:02:15,150
+لما نعبيها جوا لما نحط عليها شرطة معناته متوفة
+
+19
+00:02:15,150 --> 00:02:23,830
+فأبو الجد وأم
+
+20
+00:02:23,830 --> 00:02:29,760
+الجد أو الجدود اثنين هم متوفيناللي فيه حطيه نقطة
+
+21
+00:02:29,760 --> 00:02:34,720
+بالنص، هذه معناته «حامل» «Carrier» اللي عليه إشارة
+
+22
+00:02:34,720 --> 00:02:44,880
+كذا «مشطوب»، يعني متوفة فهنا بتتكلم عن عائلة من
+
+23
+00:02:44,880 --> 00:02:48,260
+Extended
+
+24
+00:02:48,260 --> 00:02:55,080
+Familyالجيل الرابع عندهم تمنتاشر شخص مرقمينهم واحد
+
+25
+00:02:55,080 --> 00:03:00,020
+لحد تمنتاشر واضح الجيل الثالث عشر أشخاص الجيل
+
+26
+00:03:00,020 --> 00:03:07,700
+الثاني أربع أشخاص الجيل الثاني فيه ذكور وفيه إناف
+
+27
+00:03:07,700 --> 00:03:11,160
+أثنينهم
+
+28
+00:03:11,160 --> 00:03:16,300
+مصابين أثنينهم آسف الجيل الثاني فيه ذكور وفيه إناف
+
+29
+00:03:16,300 --> 00:03:23,270
+أثنينهمحاملين للمرض Carriers لأنه صحيح أحنا بنعرف
+
+30
+00:03:23,270 --> 00:03:29,450
+أن الأم الجد أو الجيل الأول الأنثى كانت مصابة بس
+
+31
+00:03:29,450 --> 00:03:37,490
+الإصابات بالنسبة لـ .. بالنسبة من الأحفاد وأبناء
+
+32
+00:03:37,490 --> 00:03:42,250
+الأحفاد فيه بالذكور وفيه بالإناف يعني هذه الثنتين
+
+33
+00:03:45,430 --> 00:03:51,930
+اللي هي يعني فيها
+
+34
+00:03:51,930 --> 00:03:57,630
+أكثر من شخص مصادر فلما يكون أبيض تمامًا معناته
+
+35
+00:03:57,630 --> 00:04:05,130
+سليم الـ Genotype الـ Genotype النُص معناته Career
+
+36
+00:04:05,130 --> 00:04:14,250
+والـ Fullمظلّل بالكامل، هذا معناته إنسان مصاب فهيك
+
+37
+00:04:14,250 --> 00:04:20,530
+الواحد بدي يقراهم، ماشي؟ فأنا مافهمتش الزوج
+
+38
+00:04:20,530 --> 00:04:24,930
+والزوجة هنا شو الـ Genotype الـ Genotype، هاي مصاب
+
+39
+00:04:24,930 --> 00:04:32,710
+وهاي بدي يكون Free لما نقول Career، معناته هذه
+
+40
+00:04:32,710 --> 00:04:35,350
+الصفة متنحية، ماشي؟
+
+41
+00:04:38,620 --> 00:04:44,520
+ممكن تكون متنحي، ممكن تكون .. إذا في .. يعني هنا
+
+42
+00:04:44,520 --> 00:04:47,200
+بتتكلموا على إن أحيانًا
+
+43
+00:04:49,880 --> 00:04:56,960
+أحنا بنتكلم عن صفة يعني إحنا اللي بنحب هيك نفهمها
+
+44
+00:04:56,960 --> 00:05:02,480
+بسهولة وأبسط شيء فيه سائد وفيه متنحي إن السائد هو
+
+45
+00:05:02,480 --> 00:05:07,360
+اللي بيظهر والمتنحي بيختفي إلا إذا كان two copies
+
+46
+00:05:07,360 --> 00:05:13,140
+هذا الكلام مش دائما 100% بهذه الطريقة هذا الكلام
+
+47
+00:05:13,140 --> 00:05:24,740
+أحياناً مش كاملمن ناحية إن أحيانًا الصفة
+
+48
+00:05:24,740 --> 00:05:30,300
+الوراثية ما بتبين في مجموعة معينة أو في ناس معينين
+
+49
+00:05:30,300 --> 00:05:37,360
+بشكل قوي فبتلاقيها مش ظاهرة يعني فهي النقطة اللي
+
+50
+00:05:37,360 --> 00:05:43,060
+يحب واحد منكم يسألها والمقصود في الموضوع إنه يتعود
+
+51
+00:05:43,060 --> 00:05:50,300
+الواحد يقرأ عن الصفة الوراثيةكيف يقرأ الـ Pedigree
+
+52
+00:05:50,300 --> 00:05:55,520
+«Choose Simple» معناتها هنا في ذكور وفي إناث
+
+53
+00:05:55,520 --> 00:06:01,440
+مصابين وفي كل الأجيال بشكل واضح وإن كان الجيل
+
+54
+00:06:01,440 --> 00:06:07,920
+الثاني هنا مافيش مصابين، فيه Carriers اللي متوفر
+
+55
+00:06:07,920 --> 00:06:12,820
+رقم ثلاثة أنثى مابنعرفش كانت مصابة ولا غير مصابة
+
+56
+00:06:12,820 --> 00:06:26,090
+واضح إنه الصابد يعنيفي تفاوت فيها يعني هو
+
+57
+00:06:26,090 --> 00:06:32,530
+أنا لما اتكملوا بالنسبة للـ Pedigree ماحطوش كل
+
+58
+00:06:32,530 --> 00:06:37,490
+المعلومات الأخرى يعني أخدوا عيلة واحدة فقط من جانب
+
+59
+00:06:37,490 --> 00:06:42,730
+واحد يعني الشاب
+
+60
+00:06:42,730 --> 00:06:49,430
+هذا أو الزلمي هذا حتى جابالثلاث أفراد هدولة لازم
+
+61
+00:06:49,430 --> 00:06:53,590
+تتزوج بواحدة فهذه أيضًا ليست محطوطة يعني فهنا فيه
+
+62
+00:06:53,590 --> 00:07:00,630
+معلومات مش كاملة بس على الأقل يعني الواحد يعني هنا
+
+63
+00:07:00,630 --> 00:07:06,590
+career أو مش واضح يعني هيك بنعتبرها وفيه إنه
+
+64
+00:07:06,590 --> 00:07:10,640
+مصابين وفيه إنه غير مصابينأتأمل إن إن شاء الله
+
+65
+00:07:10,640 --> 00:07:19,320
+تكون الصورة هيوضحك بالنسبة لسؤال الفائل لأنه كانت
+
+66
+00:07:19,320 --> 00:07:27,500
+الأمور واضحة في أسئلة؟ في أسئلة أخرى عن اللي
+
+67
+00:07:27,500 --> 00:07:31,980
+اتناولناها المرة اللي فاتت؟
+
+68
+00:07:31,980 --> 00:07:36,780
+طيب
+
+69
+00:07:37,630 --> 00:07:46,370
+بالنسبة لليوم، بدنا نحاول نفهم لما نتكلم عن
+
+70
+00:07:46,370 --> 00:07:55,550
+الوراثة والـ Genetics في population بالنسبة للجنس
+
+71
+00:07:55,550 --> 00:08:03,370
+البشري كله بكلام عام، شو الأسس وكيف نتكلم وكيف
+
+72
+00:08:03,370 --> 00:08:10,930
+نتعامل مع موضوع زي هذهفي مفهوم حتى نعرف إيه يكون
+
+73
+00:08:10,930 --> 00:08:21,870
+عندنا مرتكز نبدأ منه في قضية فهم يعني كيفية
+
+74
+00:08:21,870 --> 00:08:29,230
+التعامل مع الوراثة في مفهوم يسمونه
+
+75
+00:08:29,230 --> 00:08:33,650
+قانون Hardy-Weinberg القانون هذا قانون الوراثة
+
+76
+00:08:33,650 --> 00:08:44,570
+بسميه قانون الوراثةإنه بالنسبة له عند وجود جين
+
+77
+00:08:44,570 --> 00:08:54,330
+أصلي ومتغير قليل له أو شكل آخر منه لما نكون هذول
+
+78
+00:08:54,330 --> 00:09:01,290
+أثنين موجودين في البشرية، في الـPopulation كلها
+
+79
+00:09:01,290 --> 00:09:10,520
+القانون هذاراح ناخده بعد شوية كيف بتعامل مع نسب
+
+80
+00:09:10,520 --> 00:09:19,740
+تواجد كل قليل بفترض هذا القانون أدت افتراضات بدي
+
+81
+00:09:19,740 --> 00:09:26,620
+الواحد يكون متنبه إلها عشان لما يتعامل يعني يكون
+
+82
+00:09:26,620 --> 00:09:32,600
+متنبه الواحد منها لاختلاف هذه الفرضية عن الواقع
+
+83
+00:09:32,600 --> 00:09:42,400
+أحيانًاالـ الـ الـ الـ population أو المجموعة اللي
+
+84
+00:09:42,400 --> 00:09:48,940
+احنا الكلية اللي عم ندرسها الأصل حتى نطبق هذا
+
+85
+00:09:48,940 --> 00:09:53,520
+القانون ونعرف نشتغل بالمعادلة تبعته ونسوي الأشياء
+
+86
+00:09:53,520 --> 00:10:00,060
+اللي فيه لازم تكون population كبيرة والتزاوج بين
+
+87
+00:10:00,060 --> 00:10:09,210
+أفراده كلهممسموح وبحدث ويعني مش مثلًا population
+
+88
+00:10:09,210 --> 00:10:15,310
+فيها two sub-populations يعني مثلًا في أمريكا
+
+89
+00:10:15,310 --> 00:10:20,350
+مثلًا نفترض البيض بيجوزوش السود والسود بيجوزوش
+
+90
+00:10:20,350 --> 00:10:26,010
+البيض ففي أمريكا مثلًا مجتمع نصف ثلاث، عشرين،
+
+91
+00:10:26,010 --> 00:10:32,830
+تلتاش، خمستاش بالمية سود وخمس وثمانينتقريبًا
+
+92
+00:10:32,830 --> 00:10:39,090
+بالمية بيرد ومافيش تزاوج بينهم إذا كان الأمر بهذه
+
+93
+00:10:39,090 --> 00:10:42,690
+الطريقة راح يخربط الدنيا ومش راح تكون القانون اللي
+
+94
+00:10:42,690 --> 00:10:49,350
+نحكي عنه منطبق فهو لـ Population كبيرة بتكون
+
+95
+00:10:49,350 --> 00:10:55,330
+إمكانية التزاوج بين أفراده مسموحة ومافيش أي
+
+96
+00:10:55,330 --> 00:11:03,110
+محددات، ماشي؟ فهذه ناحية مهمة ومبدألما نطبق
+
+97
+00:11:03,110 --> 00:11:13,870
+القانون الشيء الثاني أنه لما ندرسنا احتمالية أو
+
+98
+00:11:13,870 --> 00:11:18,810
+نسبة حدوث المتغير
+
+99
+00:11:18,810 --> 00:11:26,730
+من نوع ما للجين المتغير A أو B مثلاً سنجد أن
+
+100
+00:11:26,730 --> 00:11:32,790
+الافتراض الثاني في القانونإن النسب ثابتة يعني
+
+101
+00:11:32,790 --> 00:11:38,710
+مثلًا في population في نسبة القليل الأول تسعين
+
+102
+00:11:38,710 --> 00:11:42,570
+بالمية القليل الثاني عشرة بالمية من الناس عندهم هي
+
+103
+00:11:42,570 --> 00:11:49,580
+هكذا فمن يكون عشر أو تسعين هذه النسبة ثابتةمن إنها
+
+104
+00:11:49,580 --> 00:11:58,000
+ما بتتغيرش بسبب حدوث طفرات جديدة بتكون إنه تزاوج
+
+105
+00:11:58,000 --> 00:12:04,620
+مسموح ومافيش اختيار للنوع باتجاه نوع معين ومافيش
+
+106
+00:12:04,620 --> 00:12:10,220
+أي نوع من إدخال أو إخراج نسبة من الناس من خلال
+
+107
+00:12:10,220 --> 00:12:18,340
+الهجرات فالـ Immigrationيعني المطلوب إنه حتى نطبق
+
+108
+00:12:18,340 --> 00:12:23,840
+القانون اللي راح نحكي عنه راح يكون من خلال بيسموها
+
+109
+00:12:23,840 --> 00:12:29,700
+الـ Steady State حالة الاتزام، حالة الثبات فهذه
+
+110
+00:12:29,700 --> 00:12:38,740
+محددات أساسية في الرؤية لما نيجي نتكلم عنيعني
+
+111
+00:12:38,740 --> 00:12:44,300
+النسب والكافة الـ Diversity في المجتمع أو في الـ
+
+112
+00:12:44,300 --> 00:12:49,280
+Population بدنا ناخدها بعالي اعتبار إذا أخذنا هذه
+
+113
+00:12:49,280 --> 00:12:58,060
+النقاط بيعني بعالي اعتبار لما نيجي نتكلم عن يعني
+
+114
+00:12:58,060 --> 00:13:08,100
+كيف ننصف تفاوت البشر بالنسبة لصفة معينة ورافيةفهنا
+
+115
+00:13:08,100 --> 00:13:17,840
+أعطيكم مثال على موليكول أو على جزية أو على يعني
+
+116
+00:13:17,840 --> 00:13:24,640
+بروتين اللي يسموه CCR5 الـChemokines هذولة عبارة
+
+117
+00:13:24,640 --> 00:13:30,840
+عن مجموعة هرمونات بتتحكم في المناعة بتحدد وين
+
+118
+00:13:30,840 --> 00:13:40,030
+الخلايا بتروح فالـ Chemokines عددهم كبير ويعني
+
+119
+00:13:40,030 --> 00:13:43,910
+حوالي ما لا يقل عن مية يمكن الأنصار أو أكثر
+
+120
+00:13:43,910 --> 00:13:48,330
+اكتشفوا كلها عشان تتخلى خلايا المناعة تعرف أين
+
+121
+00:13:48,330 --> 00:13:55,490
+تروح فالـ Chemokines الأثبت والأهم هم الـReceptors
+
+122
+00:13:55,490 --> 00:14:02,350
+تبعتهم هم المستقبلات تبعتهم فعددهم بيسموه حسبالـ
+
+123
+00:14:02,350 --> 00:14:09,430
+Cytosine اللي هو Amino Acid Cytosine
+
+124
+00:14:09,430 --> 00:14:13,110
+Amino
+
+125
+00:14:13,110 --> 00:14:20,560
+Acid Particle أو Amino Acid بالـ Volume بتاعيفبيجي
+
+126
+00:14:20,560 --> 00:14:25,160
+ثنتين ورا بعض، فبيسموهم CC أنه ثنتين ورا بعض، مش
+
+127
+00:14:25,160 --> 00:14:33,940
+CXC أو CXXC يعني أنه فيه Amino Acid بينهم فالمهم،
+
+128
+00:14:33,940 --> 00:14:41,800
+الـChemokine رقم خمسة أشي مهم كمستقبل للـHIV
+
+129
+00:14:41,800 --> 00:14:49,410
+الـHIV إذا تتذكروا، بيستخدم الـCD4الـ GP120 على
+
+130
+00:14:49,410 --> 00:14:56,090
+الـ surface تبع الـ البروتين تبع الـ HIV الفيروس
+
+131
+00:14:56,090 --> 00:15:01,590
+الـ Human Immune Deficiency Virus فالـ الـ HIV
+
+132
+00:15:01,590 --> 00:15:07,510
+بيستخدم الـ CD4 موليكيون اللي على سطح الـ T-cells
+
+133
+00:15:07,510 --> 00:15:13,210
+والـ CCR5 على سطح الـ T-cells المستقبل الثاني إليه
+
+134
+00:15:13,210 --> 00:15:23,580
+فكانت ملاحظة من فترة أو كان عليها ضج كبير إنه في
+
+135
+00:15:23,580 --> 00:15:31,900
+بعض الـVariation في قابلية الخلايا إنها يتم غزوها
+
+136
+00:15:31,900 --> 00:15:40,320
+من خلال الـHIV من خلال Variations في الـCCR5ففي
+
+137
+00:15:40,320 --> 00:15:46,440
+نوع اكتشفناه بعدين بعض الناس عندهم «Delta CCR5»
+
+138
+00:15:46,440 --> 00:15:53,120
+«Deletion Elite» يعني بيصير عندهم إنه الـ «CCR5»
+
+139
+00:15:53,120 --> 00:15:57,940
+غير موجود بشكل طبيعي، عبارة عن بروتين مقطوع،
+
+140
+00:15:57,940 --> 00:16:06,740
+بروتينمش اسمه بروتيم مقطوع وبكون فيه stop codon
+
+141
+00:16:06,740 --> 00:16:14,300
+وبكون miss shift يعني الـ deletion خلّت إن قراءة
+
+142
+00:16:14,300 --> 00:16:20,100
+الـ DNA مش مظبوطة وبالتالي مافيش إنها الـ CCR5
+
+143
+00:16:20,100 --> 00:16:26,020
+القليل اللي هو مش طبيعي بكون فيه مشكلة فيه
+
+144
+00:16:30,070 --> 00:16:35,070
+رح نتفرج بعد شوية على كيف أنه بالنسبة كـ
+
+145
+00:16:35,070 --> 00:16:39,490
+population لهذا الجين
+
+146
+00:16:39,490 --> 00:16:48,310
+بالذات تم دراسته ونشوف كيف النتائج راح تكونفكان
+
+147
+00:16:48,310 --> 00:16:53,030
+فيه اهتمام بهذا الموضوع لأنه كان يفسر مقاومة البعض
+
+148
+00:16:53,030 --> 00:16:58,110
+للـ HIV قدرتهم على أنه يتعرضوا إليه بس ما ينصابوا
+
+149
+00:16:58,110 --> 00:17:07,330
+فكان مثير للاهتمام لما أجوا ودرسوا المعادلات
+
+150
+00:17:07,330 --> 00:17:12,610
+أو درسوا الوضع اللي موجود بالنسبة للـ
+
+151
+00:17:16,390 --> 00:17:23,370
+بين الـ CCR5 وبين الأليل اللي هو الـ Mutated اللي
+
+152
+00:17:23,370 --> 00:17:33,210
+هو فيه الـ Delusion اللي هو المقرب فدرسوا 788 شخص
+
+153
+00:17:33,210 --> 00:17:38,210
+الكلام بالـ 97 ماشي يعني يعني يعتبر دراسة قديمة
+
+154
+00:17:38,210 --> 00:17:46,880
+نوعاً ما درسوا حوالي 800 بني آدم ال .. ال ..البشر
+
+155
+00:17:46,880 --> 00:17:53,160
+اللي عندهم الـTwo copies normal ماشي حوالي 651
+
+156
+00:17:53,160 --> 00:17:59,160
+اللي عندهم نسخة واحدة من الـDeletion أو
+
+157
+00:17:59,160 --> 00:18:06,480
+الـAbnormal قليل مش الـWild type 134 واللي عندهم
+
+158
+00:18:06,480 --> 00:18:13,040
+Double the thing اللي هو الـMutations بالسنتين
+
+159
+00:18:13,040 --> 00:18:25,060
+سبعةفلما نحملها نسب راح نلاقي إن الـ one كاملة هي
+
+160
+00:18:25,060 --> 00:18:35,960
+الـ total للكل 82% عندهم الـ wild type 17% تقريبًا
+
+161
+00:18:35,960 --> 00:18:43,840
+عندهم one mutation واحد بالميةعندهم اللي هو الـ
+
+162
+00:18:43,840 --> 00:18:51,100
+Double Mutations وهي الأليل وهي اسمها Derived
+
+163
+00:18:51,100 --> 00:18:59,250
+Frequencies الأليل الفكرة من هناإنه لما نيجي ناخد،
+
+164
+00:18:59,250 --> 00:19:04,490
+طبعاً هنا عرفنا عنه إنه بس فيه عنا ثمان ماعناش عدد
+
+165
+00:19:04,490 --> 00:19:08,210
+أكبر من الـ Alleles يعني مثلا لما نيجي نقول إنه
+
+166
+00:19:08,210 --> 00:19:12,370
+نطبق القاعدة هذه وبهذه الطريقة تماماً على الـ ABO
+
+167
+00:19:12,370 --> 00:19:17,250
+System تبع الـ Blood Group الـ ABO System، لأ، فيه
+
+168
+00:19:17,250 --> 00:19:20,770
+ثلاث Alleles فما بيمشي عليه هذا القانون ما بتمشي
+
+169
+00:19:20,770 --> 00:19:24,650
+عليه هذه الطريقةإنما لما يكون عندى بس Two copies
+
+170
+00:19:24,650 --> 00:19:30,810
+يعني مثلًا الـ Rh Positive و Negative تبع الـ
+
+171
+00:19:30,810 --> 00:19:35,990
+Resource Factor أو الـ Blood Group الـ Rh ففي حالة
+
+172
+00:19:35,990 --> 00:19:40,390
+مثلًا الـ Rh ممكن أنا أطلع أرقام زي هيكة وأقول إن
+
+173
+00:19:40,390 --> 00:19:46,890
+البشر مثلًا كذا بالمية عندهم هيك وكذا بالمية عندهم
+
+174
+00:19:46,890 --> 00:19:47,450
+هيك
+
+175
+00:19:52,290 --> 00:19:59,250
+الملاحظة إذا افترضنا إنه الـ Frequency تبعت الـ
+
+176
+00:19:59,250 --> 00:20:04,370
+Normal أو الـ Baseline أو الـ Wild-type هنا سموه
+
+177
+00:20:04,370 --> 00:20:10,750
+الـ Wild-type يعني اللي مافيش فيه طفرة قليل النسبة
+
+178
+00:20:10,750 --> 00:20:19,870
+هنا تقريباً 91%اللي حصلناها وهنا تسعة بالمية الـ
+
+179
+00:20:19,870 --> 00:20:23,050
+«while» اللي هو تبعتر الـ «frequency» للـ
+
+180
+00:20:23,050 --> 00:20:28,490
+«mutation» للـ «abnormal» أو الـ «deleted» أو الـ
+
+181
+00:20:28,490 --> 00:20:35,650
+«abnormal» أو الـ «muted» فقط بذكر قاعدة مهمة إنه
+
+182
+00:20:35,650 --> 00:20:41,900
+تعدد الصور الـ «polymorphism» هذا لما نحكي عنهإذا
+
+183
+00:20:41,900 --> 00:20:46,240
+كان الـ mutation أكتر من 1% من الـ population فهو
+
+184
+00:20:46,240 --> 00:20:51,440
+نسبة عالية فهو نسبة كبيرة لما تكون 1% طبعا إذا 1%
+
+185
+00:20:51,440 --> 00:20:56,840
+مصاب بالـ gene هذا في نسبته بال population راح
+
+186
+00:20:56,840 --> 00:20:57,320
+يكون
+
+187
+00:21:00,140 --> 00:21:06,360
+تقريبًا راح يكون تقريبًا واحد بالعشر تلاف بين
+
+188
+00:21:06,360 --> 00:21:10,740
+الولادات عنده الإصابة هذه لأنه واحد بالمية في واحد
+
+189
+00:21:10,740 --> 00:21:15,640
+بالمية بيصير هيك النقطة يعني اللي بدنا نفهمها
+
+190
+00:21:15,640 --> 00:21:23,740
+وننتبه إليها بالنسبة لمثل هيك معادلة أنه شو
+
+191
+00:21:23,740 --> 00:21:29,290
+العلاقة بين هذول الرقمين وبين هالثلاث أرقامالرقم
+
+192
+00:21:29,290 --> 00:21:38,110
+الأول فوق هو يمثل 0.9%² إذا اعتبرنا إنه الـ
+
+193
+00:21:38,110 --> 00:21:44,630
+Frequency تبعت الـ CCR5 هي الـ P ماشي فرح تكون
+
+194
+00:21:44,630 --> 00:21:52,370
+اللي هي 0.9 فـ 0.9 تربيع رح تعطينا النسبة الأولى
+
+195
+00:21:52,370 --> 00:22:01,390
+اللي هي 81% أو 82%النفس الطريقة الأليل الـ deleted
+
+196
+00:22:01,390 --> 00:22:12,090
+اللي هو 9% لما نكون 9% أو almost 10% 10% يعني اللي
+
+197
+00:22:12,090 --> 00:22:23,630
+هو 10%×10% بيطلع 1% ماشي 0.1×0.1 بيطلع 0.01 فبتطلع
+
+198
+00:22:23,630 --> 00:22:30,630
+لك هيكوهذه تمثل «2PQ» الـ «P» اللي هي الـ
+
+199
+00:22:30,630 --> 00:22:34,310
+frequency تبع الأليل الأول والـ «Q» تبع الأليل
+
+200
+00:22:34,310 --> 00:22:39,950
+الثاني إذا بتضرب هدول اثنين الـ «2PQ» بتضرب هدول
+
+201
+00:22:39,950 --> 00:22:48,310
+الرقمين بعض يعني 90% في 10%، بتصير 9% 9% في 2،
+
+202
+00:22:48,310 --> 00:22:53,510
+تقريبًا 17% اللي شفناها هنا فالمعادلة اللي بيحكوا
+
+203
+00:22:53,510 --> 00:23:02,360
+عنهااللي هي يعني إنه نتذكر دايماً إنه P تربيع زائد
+
+204
+00:23:02,360 --> 00:23:08,060
+2PQ زائد Q تربيع بساوي واحد هيك يعني اللي بدنا
+
+205
+00:23:08,060 --> 00:23:15,760
+ناخدها اللي هي إنه مجموع هذولة القطعة الثلاثة اللي
+
+206
+00:23:15,760 --> 00:23:22,770
+هي الـMendelian inheritance الـSingle Geneالـ
+
+207
+00:23:22,770 --> 00:23:29,410
+Frequency للقليل الأول تربيع بالـ Homozygous زاد
+
+208
+00:23:29,410 --> 00:23:35,930
+الـ Frequency للقليل الثاني بالـ Homozygous وضعف
+
+209
+00:23:35,930 --> 00:23:41,690
+عدد الـ Heterozygous بتجمعهم كلهم بطلعة من واحد في
+
+210
+00:23:41,690 --> 00:23:50,350
+حالة الـ Equilibriumاللي هي لما يكون كل الصفات
+
+211
+00:23:50,350 --> 00:23:55,030
+اللي حكيناها population كبيرة مافيش فيها migration
+
+212
+00:23:55,030 --> 00:23:58,970
+مافيش limitation، عز وجل، بين مجموعة ومجموعة
+
+213
+00:23:58,970 --> 00:24:03,470
+والأمور مافيه mutation جديدة والأمور in a steady
+
+214
+00:24:03,470 --> 00:24:11,750
+state وكل الشروط هذه متحققة، الأمر بنتج عنه إن
+
+215
+00:24:11,750 --> 00:24:14,570
+مجموع القيم هذه لازم تساوي واحدة
+
+216
+00:24:18,210 --> 00:24:28,950
+فالآن لما نأخذ مثلًا نفترض إنه أنا بعرف الـ
+
+217
+00:24:28,950 --> 00:24:37,850
+Genotype هل هو Homozygous dominant أو Heterozygous
+
+218
+00:24:41,450 --> 00:24:48,150
+Homozygous, Recessive أو Heterozygous فلما أعرف
+
+219
+00:24:48,150 --> 00:24:57,390
+النسب ماشي بقدر أشوف كام بتصير احتمالية أنه يكون
+
+220
+00:24:57,390 --> 00:25:02,870
+نوعية معينة من الـ … إذا كان عندي الـ «mating» بـ
+
+221
+00:25:02,870 --> 00:25:06,450
+frequency بالأول وبتشوف شو الـ «offspring» راح
+
+222
+00:25:06,450 --> 00:25:17,850
+يطلعوبكون أنا في حالة يعني مثلًا «Aa»
+
+223
+00:25:17,850 --> 00:25:25,650
+مع «Aa» يعني إذا مثلًا إثنينهم هتروا زيكي مثلًا
+
+224
+00:25:25,650 --> 00:25:34,510
+«Aa» هاي راح يطلع عنها «4Q2B²Q²»
+
+225
+00:25:34,510 --> 00:25:35,530
+«4Q2B²Q²» «4Q2B²Q²» «4Q2B²Q²» «4Q2B²Q²» «4Q2B²Q²»
+
+226
+00:25:35,530 --> 00:25:36,950
+«4Q2B²Q²» «4Q2B²Q²» «4Q2B²Q²» «4Q2B²Q²» «4Q2B²Q²»
+
+227
+00:25:36,950 --> 00:25:36,990
+«4Q2B²Q²» «4Q2B²Q²» «4Q2B²Q²» «4Q2B²Q²» «4Q2B²Q²»
+
+228
+00:25:36,990 --> 00:25:43,320
+«4Q2B²Q²» «4Q2B²Q²» «هذولا إثنين هما يعني الـ
+
+229
+00:25:43,320 --> 00:25:49,300
+Offspring راح يكون الرُبع AA Capital الرُبع AA
+
+230
+00:25:49,300 --> 00:25:58,920
+Small أو Recessive والنُص راح يكونوا Heterozygous
+
+231
+00:25:58,920 --> 00:26:10,400
+فهي يعني مدخل لكيف إحنابنفكر لما نتكلم عن الـ
+
+232
+00:26:10,400 --> 00:26:19,160
+Frequencies تبعات الـ Certain Genotypes وكيف نسبهم
+
+233
+00:26:19,160 --> 00:26:24,320
+ووجودهم في المجتمعات، في الـ Populationوش هو همية
+
+234
+00:26:24,320 --> 00:26:27,920
+دراسة هذا الموضوع؟ إذا في حد عنده سؤال، يعني
+
+235
+00:26:27,920 --> 00:26:39,060
+أنا…………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………
+
+236
+00:26:48,740 --> 00:26:57,620
+قليل لما تدرس نسبته تسميها الـP الـMutated أو
+
+237
+00:26:57,620 --> 00:27:00,660
+الجين
+
+238
+00:27:00,660 --> 00:27:06,340
+الثاني اللي خربان أو فيه مرض أو فيه مشكلة تسميه
+
+239
+00:27:06,340 --> 00:27:15,170
+الـQ فإذا هنا لدراسة صفة معينة عندك Two Genesزي ما
+
+240
+00:27:15,170 --> 00:27:21,790
+حكينا عن مثال الـ «Gene» تبع الـ «CCR5» إبارة عن
+
+241
+00:27:21,790 --> 00:27:30,550
+إحنا اهتمنا في دراسته لأنه يمثل إحتمالية
+
+242
+00:27:30,550 --> 00:27:35,250
+الإصابة بالـ «HIV» والـ «Susceptibility» تبعته
+
+243
+00:27:35,250 --> 00:27:37,650
+يعني، لماذا بعض الناس بنصاب ولماذا بعض الناس
+
+244
+00:27:37,650 --> 00:27:42,350
+بنصبوه؟ فدرست هذا الـ «Gene» فانتبهت إنه عندي
+
+245
+00:27:42,350 --> 00:27:48,170
+إثنين منهمفالـ Wild-type العادي الأصلي بسمّي الـ
+
+246
+00:27:48,170 --> 00:27:53,050
+Frequency تبعته نسبة حدوثه في الاحتمالات بأعطيها
+
+247
+00:27:53,050 --> 00:28:01,290
+الرقم P و الـ Q هي نسبة الطفرة اللي هي قداش نسبة
+
+248
+00:28:01,290 --> 00:28:08,350
+حدوثها على أساس أنه زي ما رسمناه هنا بالمثال هذا
+
+249
+00:28:08,350 --> 00:28:15,440
+الـ P هي الـ Frequency تبعت الـ CCR5بنعطيها الـ «0
+
+250
+00:28:15,440 --> 00:28:22,200
+.9» وهذه بأعطيها «P» والـ «Delta» «CCR5» الـ
+
+251
+00:28:22,200 --> 00:28:28,300
+«Mutated» «Deleted» قليل بأعطيها «0.09» يعني «0.1
+
+252
+00:28:28,300 --> 00:28:34,660
+%» يعني عشرة بالمية هيك فتسعة بالمية «P» وعشرة
+
+253
+00:28:34,660 --> 00:28:43,020
+بالمية الـ «Q» كل المعادلات اللي بيحكونا دولةهو
+
+254
+00:28:43,020 --> 00:28:52,760
+أعقد مثال لـ «جين 1»، واضحة؟ دكتور، أسماء كانت
+
+255
+00:28:52,760 --> 00:28:57,000
+تسأل كيف الشقة التانية، بس يبدو وصلتها الفكرة
+
+256
+00:28:57,000 --> 00:29:00,880
+«كريم» بيقول يعني، «شو بتفيد دي هذه المعادلة؟»
+
+257
+00:29:00,880 --> 00:29:03,580
+يعني إيش المقصود بالـ frequency؟ مرة أخرى بيسأل
+
+258
+00:29:04,650 --> 00:29:14,370
+الآن نأتي مثلًا نأخذ موضوع دائمًا أحب أن نضرب مثال
+
+259
+00:29:14,370 --> 00:29:21,470
+عليه مثلًا، بنك الدم أنا
+
+260
+00:29:21,470 --> 00:29:31,630
+بهمني عشان أسهل إعطاء دم للناس حسب نسب الـA والـB
+
+261
+00:29:31,630 --> 00:29:39,000
+والـO groupبهمني يعني هذا مثال مش راح يظبط تماماً
+
+262
+00:29:39,000 --> 00:29:46,060
+مية بالمائة بس بدي أوصل فكرة معينة بالنسبة لما أنا
+
+263
+00:29:46,060 --> 00:29:50,460
+آجي كام نسبة الـA وكم نسبة الـO وكم نسبة الـB
+
+264
+00:29:50,460 --> 00:30:01,060
+بتفيدني يعني أنا مثلاً في بنك دم وبدي أجهز مثلاً
+
+265
+00:30:01,060 --> 00:30:07,490
+لمعركة أو لـأحتياجي في مدة طويلة أو كذا فبهمني
+
+266
+00:30:07,490 --> 00:30:15,770
+أعرف كام نسبة كل قليل موجود وقداش أجهز من هذا
+
+267
+00:30:15,770 --> 00:30:20,810
+وقداش أجهز من هذا، وش أعمل لك كذا ولي هيك فأحيانًا
+
+268
+00:30:20,810 --> 00:30:25,530
+لما تيجي و راح ناخد أمثلة أخرى لاستفادات لهذه
+
+269
+00:30:25,530 --> 00:30:35,870
+النسب أو لهذهالـ Frequency اللي هي يعني نسبة حدوث
+
+270
+00:30:35,870 --> 00:30:42,630
+أو احتمالية حدوثها تكون بشكل معين فالـ يعني اللي
+
+271
+00:30:42,630 --> 00:30:46,650
+بدك تاخده بس خلّينا نعدي هاي شوية بتشوف أنثى لي
+
+272
+00:30:46,650 --> 00:30:52,010
+كيف أشياء مفيدة أنك تعرف هذه الأرقام الـ P هي الـ
+
+273
+00:30:52,010 --> 00:31:04,380
+Frequency تبعت الـ Wild-type geneالـ Q هي نسبة الـ
+
+274
+00:31:04,380 --> 00:31:10,000
+Frequency تبع الـ Mutated Genes المثال اللي حطيناه
+
+275
+00:31:10,000 --> 00:31:17,260
+من قبل شوية اللي هو CCR5 وDelta CCR5 كانت النسب في
+
+276
+00:31:17,260 --> 00:31:23,140
+Population يعني أنا بفرجيكي إياها بهذا الشكل يعني
+
+277
+00:31:23,140 --> 00:31:24,060
+هذا مثال
+
+278
+00:31:28,510 --> 00:31:34,770
+لما درسوا في population
+
+279
+00:31:34,770 --> 00:31:41,550
+مختلفة في أماكن مختلفة في مدن وفي بلاد مختلفة ما
+
+280
+00:31:41,550 --> 00:31:49,970
+هي الـ Frequency تبعت الـ Delta CCR5أحنا حكينا
+
+281
+00:31:49,970 --> 00:31:57,670
+التقدير المتوسط حسب ذلك الدراسة 9% أو Point أو 10%
+
+282
+00:31:57,670 --> 00:32:03,010
+يعني هنا تقريبًا فاللي بدي أفرجيكيها إنه في
+
+283
+00:32:03,010 --> 00:32:08,490
+المناطق اللي تم دراسة الموضوع هذا بلاد مثلًا زي
+
+284
+00:32:08,490 --> 00:32:16,910
+هنا الصين «بنجلدش» الهند «باكستان» «سعودية»النسبة
+
+285
+00:32:16,910 --> 00:32:24,350
+لـ «CCR5» «Delta CCR5» اللي هو الـ Mutated Gene
+
+286
+00:32:24,350 --> 00:32:29,850
+كانت نسبة قليلة جداً، صفر في population معينة
+
+287
+00:32:29,850 --> 00:32:38,470
+بينما فيه لما ندرسه مثلاً في أماكن زي شمال أوروبا
+
+288
+00:32:38,470 --> 00:32:44,370
+في هذا المكان زي فنلندا والسويد والدانيمارك والـ
+
+289
+00:32:44,650 --> 00:32:49,350
+بولندا يمكن هنا لقوا
+
+290
+00:32:49,350 --> 00:32:56,690
+نسبة الـ Mutated Genes ضعف أو ضعف الـ 18% نسبة
+
+291
+00:32:56,690 --> 00:33:01,770
+عالية كثيرة فهذا حسب الدراسات يعني هنا هذه نوع من
+
+292
+00:33:01,770 --> 00:33:10,330
+الخارطة العالمية لتفاوت الـ population أنتم
+
+293
+00:33:10,330 --> 00:33:14,390
+تشاهدون الصورة الكاملةبما فيه الـ Caption تبعتها،
+
+294
+00:33:14,390 --> 00:33:23,510
+صح؟ الـ… هنا الـDelta CCR5 أليل
+in various
+
+295
+00:33:23,510 --> 00:33:27,810
+geographical regions in Europe وMiddle East
+
+296
+00:33:27,810 --> 00:33:31,790
+وIndian subcontinent في أماكن في العالم الصورة
+
+297
+00:33:31,790 --> 00:33:38,510
+بهذا الشكل بتخلى إنه نسبة حدوث لما ركزوا على إنهم
+
+298
+00:33:38,510 --> 00:33:43,880
+يهتموا بهذا النوع من الـGene Mutationلقوا إنه فيه
+
+299
+00:33:43,880 --> 00:33:51,420
+تفاوت بين البشر بالنسب بس هذه يعني نوع من بالأخير
+
+300
+00:33:51,420 --> 00:33:55,100
+يعني عرفوا يرسموا الصورة هذه من الـ Frequency تبعت
+
+301
+00:33:55,100 --> 00:34:02,720
+الـ Alleles اللي هي الـ P و الـ Q، ماشي؟ هنا اللي
+
+302
+00:34:02,720 --> 00:34:09,950
+ممثل بالرمز هنا هو الـ Q، ماشي؟وكل ما كانت نسبته
+
+303
+00:34:09,950 --> 00:34:16,870
+أكبر، شو اسمه؟ بتكون الأمور بهذا الشكل بس بدي أذكر
+
+304
+00:34:16,870 --> 00:34:23,990
+إنه هذا الآن على نموذج افتراضي اللي هو الـ Hardy
+
+305
+00:34:23,990 --> 00:34:28,350
+-Weinberg Law وبكون إنه population stable
+
+306
+00:34:28,350 --> 00:34:32,310
+population مافيش فيها migration مافيش فيها new
+
+307
+00:34:32,310 --> 00:34:38,390
+mutation الـ mating أو الزواج مفتوحفي كل الاتجاهات
+
+308
+00:34:38,390 --> 00:34:49,590
+فهو مثال على دراسة تمت أو دراسات تمت لفهم تفاوت
+
+309
+00:34:49,590 --> 00:34:57,510
+البشر في نوعية mutation معينة بطفرة معينة هنا بدنا
+
+310
+00:34:57,510 --> 00:35:02,630
+نسميها polymorphism يعني ما ما أقدر أعتبرها زي
+
+311
+00:35:02,630 --> 00:35:06,350
+الـGenetic mutation اللي هي very very very rare
+
+312
+00:35:06,960 --> 00:35:11,800
+اللي مثلًا طبعًا الـ Frequency للـ Polymorphism
+
+313
+00:35:11,800 --> 00:35:17,980
+بذكر هي الـ 1% إذا الواحد أكتر من 1% معناته
+
+314
+00:35:17,980 --> 00:35:26,540
+Frequent ماشي، في سؤال المعادلات
+
+315
+00:35:26,540 --> 00:35:32,360
+هذه أمثلة على كيف بعدين نستفيد من المعادلات بحيث
+
+316
+00:35:32,360 --> 00:35:37,270
+أنه يعني هذا راح نحتاجهفي قضية بن قوسين الـ
+
+317
+00:35:37,270 --> 00:35:45,590
+Genetic Counseling لما ييجي مثلًا عيلة عندهم مثلًا
+
+318
+00:35:45,590 --> 00:35:49,550
+مرض معين بيّن بالطفل الأول واتغلبوا اللّه بعدين
+
+319
+00:35:49,550 --> 00:35:55,110
+اللّه أخذوا داعته وتوفى الطفل الأول بيرجي لو كان
+
+320
+00:35:55,110 --> 00:36:02,320
+عندنا تصورما هو نوعية الـ Frequency تبع الـ Gene
+
+321
+00:36:02,320 --> 00:36:07,360
+Mutation؟ وما هو نوعية الـ Inheritance؟ وما هي
+
+322
+00:36:07,360 --> 00:36:12,310
+المعادلات التي استطيع استفيد منها؟ممكن أعطي
+
+323
+00:36:12,310 --> 00:36:17,030
+احتمالية تساعد الأهل هذولة أن يقرروا يخلفوا مرة
+
+324
+00:36:17,030 --> 00:36:21,490
+ثانية و لا ميخلفوش مرة ثانية و لا يعملوا إشي و لا
+
+325
+00:36:21,490 --> 00:36:25,610
+يتطلقوا و لا يبقى فيش داعي كام للزواج مع بعض و كذا
+
+326
+00:36:25,610 --> 00:36:31,250
+يعني احنا بنسوي نوع من هذا الأمر مثلا يعني اللي هو
+
+327
+00:36:31,250 --> 00:36:34,930
+فحص قبل الزواج بالنسبة لقضية الثلاثيميا وأمراض
+
+328
+00:36:34,930 --> 00:36:42,230
+الدمالثلاثيمية أو أمراض الدم تجد أنه يعني الأصل أن
+
+329
+00:36:42,230 --> 00:36:49,990
+الواحد ذا أثنين من الأشخاص الزوج والزوجة مقبلين
+
+330
+00:36:49,990 --> 00:36:55,830
+على الزواجإثنين هما عندهم طفرة بشكل معين بتخلّينا
+
+331
+00:36:55,830 --> 00:37:01,550
+ننصح إنه والله يعني اللي هي مبدأ حديث الرسول صلى
+
+332
+00:37:01,550 --> 00:37:06,190
+الله عليه وسلم «غربوا في النكاح أو تربوا لقدوا»
+
+333
+00:37:06,190 --> 00:37:11,110
+يعني لا تضمروا إنه يواحد يظل يخذ من أقاربه وإنه
+
+334
+00:37:11,110 --> 00:37:17,690
+يبعد في الزواج وكذا وكذا فهذه مبادئ يعني ترتبط بإن
+
+335
+00:37:17,690 --> 00:37:24,040
+الواحد يكون عنده تصور كام نسبحدوث كل نوع من الـ
+
+336
+00:37:24,040 --> 00:37:29,700
+Genotypes ويكون الـ Wild-type اللي هو الـ P والـ
+
+337
+00:37:29,700 --> 00:37:37,460
+والطفرة أو الـ Mutation اللي هي الـ Q وفي حالة الـ
+
+338
+00:37:37,460 --> 00:37:44,540
+Steady State في حالة لما يكون ما فيش يعني مغيرات
+
+339
+00:37:44,540 --> 00:37:50,050
+بتأثر على الموضوع هذا ويكون الأمور Stableبكون
+
+340
+00:37:50,050 --> 00:37:56,130
+مجموع القيم واحد تساوي كل total بتساوي واحد وتكون
+
+341
+00:37:56,130 --> 00:38:01,770
+بهذا الشكل، في أسئلة؟
+
+342
+00:38:01,770 --> 00:38:09,890
+في سؤال يا دكتور من كريم، بقول إنه ألجيت أنا لما
+
+343
+00:38:09,890 --> 00:38:16,980
+أعرف إن الـ frequency للأبوين هو Q4، هذا بيأثرمش
+
+344
+00:38:16,980 --> 00:38:27,480
+عارف هو إيه السؤال كان؟ شوف، بالنسبة للمن يكونوا
+
+345
+00:38:27,480 --> 00:38:32,720
+الـoffspring أو الـ4Q جزء و آسف، الـ4Q يمكن هذا
+
+346
+00:38:32,720 --> 00:38:38,280
+بيعني إنهم عرضة للطفرات أكثر من اللي عندهم الـ4B
+
+347
+00:38:38,280 --> 00:38:46,310
+يعني، بيسأل، يعني هيك صح الانستنتاج تبعه؟لأ لأ،
+
+348
+00:38:46,310 --> 00:38:57,450
+الآن شوف افرض خلّيني نرجع نشرحها مرة أخرى افرض الـ
+
+349
+00:38:57,450 --> 00:39:02,550
+«CCR5»
+
+350
+00:39:02,550 --> 00:39:08,670
+هذا الـ «فيتال» اللي أخدناه الـ Normal في 90% الـ
+
+351
+00:39:08,670 --> 00:39:10,770
+«CCR5» طيب
+
+352
+00:39:13,610 --> 00:39:20,430
+وإحتمالية الطفرة 10% خلّينا ناخدها بهذا الشكل،
+
+353
+00:39:20,430 --> 00:39:26,030
+تمام؟ دكتور أخلي كريم يسأل السؤال تبعه
+
+354
+00:39:30,570 --> 00:39:36,550
+نعم، أنا فاهم إن الـB معناته إنه لا يوجد فيه طفلة،
+
+355
+00:39:36,550 --> 00:39:43,450
+هذا شيء سائد، و الـQ هذا برمز للجيل المحيط، صحيح؟
+
+356
+00:39:43,450 --> 00:39:52,490
+برمز للـFrequency، للاحتمالية، كم تواجد هذا الجيل،
+
+357
+00:39:52,490 --> 00:39:58,710
+فإحنا مثلا، لو قلتلك، زي المثال اللي حكينا، شو
+
+358
+00:39:58,710 --> 00:40:10,670
+احتمالية؟إن إنسان عنده طفرتين، ماشي؟ بالنسبة لما
+
+359
+00:40:10,670 --> 00:40:18,850
+أنت تاخد مثل هذا المثال، ماشي؟ الآن، بالأخير الـP
+
+360
+00:40:18,850 --> 00:40:25,010
+هي الـFrequency اللي هي نسبة حدوث إنه يكون CCR5
+
+361
+00:40:25,010 --> 00:40:33,870
+فهي 90%، Point Nineوالـ «دلتا CCR πاي» point one
+
+362
+00:40:33,870 --> 00:40:39,630
+يعني عشرة بالمئة نفترض هيك نقربها ماشي فأنا لو
+
+363
+00:40:39,630 --> 00:40:47,730
+سألتك قداش احتمالية واحد يكون عنده طفرتين راح تقول
+
+364
+00:40:47,730 --> 00:40:53,490
+لي point one to point one بتساوي point O one فهذه
+
+365
+00:40:53,490 --> 00:40:59,840
+النسب اللي أنا بتوقعها لأن هناB تربية اللي هي الـ
+
+366
+00:40:59,840 --> 00:41:07,580
+P هذه تربية وهنا Q تربية وهنا 2PQ بس لو جبنا
+
+367
+00:41:07,580 --> 00:41:14,760
+بالمثال هذا شو احتمالية الـ الـ الأم إذا اعتبرنا
+
+368
+00:41:14,760 --> 00:41:21,160
+احتمالية الـ A الواحدة هي P ماشي فشو احتمالية واحد
+
+369
+00:41:21,160 --> 00:41:29,490
+dominant AA mother تتزوج dominantالـ AA father راح
+
+370
+00:41:29,490 --> 00:41:34,910
+يصير أنه يعني لما تيجي تاخد بالـ population مثلا
+
+371
+00:41:34,910 --> 00:41:45,690
+هي 90% ماشي 90% الـ A الـ dominant و الـ A small 0
+
+372
+00:41:45,690 --> 00:41:52,810
+.1 إذا أخدتها فشو احتمالية أنه يكونوا AA capital
+
+373
+00:41:52,810 --> 00:42:01,300
+إذا تضرب P تربيعوهذه P تربية فالاحتمالية لـ
+
+374
+00:42:01,300 --> 00:42:05,100
+Frequency تبعت الـ AA والـ Offspring كلهم راح
+
+375
+00:42:05,100 --> 00:42:08,720
+يكونوا Capital A Capital A راح يكونوا بهذا الشكل
+
+376
+00:42:08,720 --> 00:42:15,600
+ماشي فإذا بتاخدها population معينة راح تلاقي
+
+377
+00:42:15,600 --> 00:42:22,920
+نسبتهم في ال population P تقعيد أو قصر أربعة راح
+
+378
+00:42:22,920 --> 00:42:28,460
+تلاقيها بهذا الشكل يعنيإذا 90% في 90% في Ipoint 81
+
+379
+00:42:28,460 --> 00:42:34,900
+في Ipoint 81 راح يطلع حوالي 64% من الـ Population
+
+380
+00:42:34,900 --> 00:42:41,080
+يعني هاي النسب لنوعية
+
+381
+00:42:41,080 --> 00:42:47,000
+الـ Mating يعني النسب المتوقعهذه أحيانًا معلومات
+
+382
+00:42:47,000 --> 00:42:51,200
+مهمة ومفيدة حكيت بالنسبة للـ Genetic Counseling
+
+383
+00:42:51,200 --> 00:42:57,420
+بالنسبة ل… يعني راح نأخذ تطبيقات إلها في أفكار
+
+384
+00:42:57,420 --> 00:43:02,520
+معينة بس حتى يظبط الكلام هذا نرجع مرة ثانية، بدك
+
+385
+00:43:02,520 --> 00:43:05,960
+تنتبه إنه لازم تكون الـ Population في Steady State
+
+386
+00:43:05,960 --> 00:43:13,060
+والـ Netting مسموح، مافيش أي محددات عليه، لأنه فيه
+
+387
+00:43:13,060 --> 00:43:17,800
+كمان محدداتتخرب على الموضوع هذا، أيوة كريم، في
+
+388
+00:43:17,800 --> 00:43:23,020
+عندك سؤال؟ إن شاء الله واضحة كمان، نقطة بس صغيرة،
+
+389
+00:43:23,020 --> 00:43:25,960
+في الـ يكون الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+390
+00:43:25,960 --> 00:43:26,480
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+391
+00:43:26,480 --> 00:43:29,200
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+392
+00:43:29,200 --> 00:43:29,400
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+393
+00:43:29,400 --> 00:43:29,840
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+394
+00:43:29,840 --> 00:43:32,600
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+395
+00:43:32,600 --> 00:43:33,300
+الـ الـ الـ الـ الـ الـ
+
+396
+00:43:36,500 --> 00:43:40,900
+بيكون عندي جنسيات جيبحي زي اللي في النص ليش بنحط
+
+397
+00:43:40,900 --> 00:43:45,840
+اتنين جاب اللي بيقولوا انها علاقة معينة اشي هادا؟
+
+398
+00:43:45,840 --> 00:43:52,540
+الاحتمالية يكون من هذا النوع لما انت تاخد capital
+
+399
+00:43:52,540 --> 00:43:59,280
+A، small a تزاوج مع capital A، small a يعني لما
+
+400
+00:43:59,280 --> 00:44:03,900
+تاخد انت اللي هو المثال هذا شايف الخط اللي أنا
+
+401
+00:44:03,900 --> 00:44:04,740
+بأشير عليه؟
+
+402
+00:44:08,000 --> 00:44:15,040
+ماشي، ماشي، احتماليات
+
+403
+00:44:15,040 --> 00:44:18,720
+للناتج،
+
+404
+00:44:18,720 --> 00:44:30,680
+ماشي، بالنسبة للنسب، راح تكون، يعني، راح تقول، أنت
+
+405
+00:44:30,680 --> 00:44:34,260
+أصلا بتقول بالأول capital A، capital A هي الربع
+
+406
+00:44:34,990 --> 00:44:40,310
+وSmall a Small a هي الربع والـ Capital A Small a
+
+407
+00:44:40,310 --> 00:44:47,790
+هي النصف، إيه راح تقول نتيجة؟ فلما تأخذها برموز،
+
+408
+00:44:47,790 --> 00:44:58,650
+يعني إذا تردنا إن الأمور Stable اللي هو 8 أو 4 بيه
+
+409
+00:44:58,650 --> 00:45:04,440
+تربيع، Q تربيع بتسوي واحديعني لو كان اتنينهم fifty
+
+410
+00:45:04,440 --> 00:45:10,300
+-fifty percent بتكون راح تكون النسب ربع ونص وربع،
+
+411
+00:45:10,300 --> 00:45:17,860
+مش هيكت؟ فهي الفكرة
+
+412
+00:45:17,860 --> 00:45:29,390
+هنا اللي احنا أنا لسه بتجاوز قضية سائد ومتنحيبشكل
+
+413
+00:45:29,390 --> 00:45:34,870
+يعني أنا مش هنا بس بتكلم لما يكون عندك صفة وراثية
+
+414
+00:45:34,870 --> 00:45:41,970
+سائد أو متنحي أنا بتكلم على نسبة أنه زي مثلا
+
+415
+00:45:41,970 --> 00:45:45,710
+الـGene تبع الـCCR5 هذا اللي اتكلمنا عنه كميتال
+
+416
+00:45:45,710 --> 00:45:51,970
+كيف أنه في ال population فيه تفاوت بينهم حسة ليش
+
+417
+00:45:51,970 --> 00:45:57,890
+قال هو سائد ومتنحيالسائل اللي عنده سائد أو الطبيعي
+
+418
+00:45:57,890 --> 00:46:02,670
+فيه gene expression فهيتلاقي protein للـReceptor
+
+419
+00:46:02,670 --> 00:46:08,990
+هذا والله علم شو بيشتغل الـCCR5Delta اللي هي
+
+420
+00:46:08,990 --> 00:46:15,710
+الـMutated Alien هل هو مرض؟ هل هو يمثل إعاقة يعني؟
+
+421
+00:46:15,710 --> 00:46:19,770
+لأ، بس هو الـGene موجود في المجتمع بدنا ندرس قداش
+
+422
+00:46:19,770 --> 00:46:27,750
+هو والمثال اللي بنحكيه هنا اللي هو لـيعني دراسة عن
+
+423
+00:46:27,750 --> 00:46:33,550
+هذا الموضوع وقداش نسبهم بين الـ «populations»
+
+424
+00:46:33,550 --> 00:46:41,190
+المختلفة، ماشي؟ خلّيني أنا أنني أخد أمثلة تانية،
+
+425
+00:46:41,190 --> 00:46:46,690
+يمكن تتوضح الأمور أكتر، أيوة، احكي «الجين المتلحح
+
+426
+00:46:46,690 --> 00:46:52,310
+يعطيك ضفرة أو مرض» نعم «الجين
+
+427
+00:46:52,310 --> 00:46:56,180
+المتلحح يعطيك ضفرة أو مرض»أه طبعاً لأ ما .. ما ..
+
+428
+00:46:56,180 --> 00:47:02,700
+يعني مثلاً لما تقول الـ A B O system ماشي الـ O شو
+
+429
+00:47:02,700 --> 00:47:08,580
+ضررها؟ شو قملك؟ صح في حالات معينة بتسببلك مشكلة
+
+430
+00:47:08,580 --> 00:47:12,760
+معينة اللي انت كدهاش تعطي بالنقل شغل معين بس اللي
+
+431
+00:47:12,760 --> 00:47:18,040
+كإنسان طبيعي هيك ماشي أمان الله وإنسان طبيعي شو
+
+432
+00:47:18,040 --> 00:47:23,690
+هتفرد؟يعني حسا مثلا يعني إذا بتأمل أنكم منتبهين
+
+433
+00:47:23,690 --> 00:47:27,330
+للـCorona أو مع الـCorona مين الـBlood group اللي
+
+434
+00:47:27,330 --> 00:47:34,270
+فيها مشكلة مع الـCorona؟ بيقولوا الـO ينتهي أكتر
+
+435
+00:47:34,270 --> 00:47:39,370
+أظن الـA بيحكوا ولا الـO؟ أظن يعني في Blood group
+
+436
+00:47:39,370 --> 00:47:47,770
+بيقولوا إنه بيموتوا أكتر، بتسبب مرض أشد، حسا الآن
+
+437
+00:47:48,230 --> 00:47:53,330
+أحيانًا وأنا بتكلم عن الجين وبدور عليه وبعمل دراسة
+
+438
+00:47:53,330 --> 00:47:57,950
+وكذا ما بكونش فاهم كل الصورة تمامًا يعني فهذا اللي
+
+439
+00:47:57,950 --> 00:48:07,990
+أنا بحاول أني أسويه، ماشي؟ النقطة اللي بعدها لسه
+
+440
+00:48:07,990 --> 00:48:13,920
+الـ Gene Frequency اللي حكينا عنهاهذه على الـ
+
+441
+00:48:13,920 --> 00:48:19,920
+Autosomal Genes وهذه لما حكينا 0.9 للـ Wild-type
+
+442
+00:48:19,920 --> 00:48:30,520
+Genes و0.1 للـ Mutated Genes مثلا من الطفرة معينة
+
+443
+00:48:30,520 --> 00:48:36,320
+لسه هذا كمان النسب راح تكون طريقتها مختلفة بالنسبة
+
+444
+00:48:36,320 --> 00:48:42,810
+لما يكون عندي X-linked Genes الـ X-linked Genesلما
+
+445
+00:48:42,810 --> 00:48:49,210
+أنا أحط الـ Frequency يعني
+
+446
+00:48:49,210 --> 00:48:54,030
+كمثال هنا على الـ Color Blindness اللي هو Vision
+
+447
+00:48:54,030 --> 00:49:03,370
+اللي هو عمل ألوان تبع الإبصار فالـ لما ناخد على
+
+448
+00:49:03,370 --> 00:49:06,610
+الـ X-Chromosome ماشي
+
+449
+00:49:08,580 --> 00:49:12,440
+وهنا نيجي طبعاً بسبب إنه الـ males عندهم one copy
+
+450
+00:49:12,440 --> 00:49:19,740
+بس فإذا كان الـ X wild type اللي هو الجين العادي
+
+451
+00:49:19,740 --> 00:49:29,840
+بيكون normal color بجنها هي نسبتها 92% كجين الذكور
+
+452
+00:49:29,840 --> 00:49:39,830
+ماشي نسبة ال color blindness 0.08 يعني 8%الـQ،
+
+453
+00:49:39,830 --> 00:49:44,750
+اللي هي نسبة الـGene الـMutation تبع الـColor
+
+454
+00:49:44,750 --> 00:49:53,110
+Blinds one copy بتكون بتكفي حتى يكون عندنا مرض عند
+
+455
+00:49:53,110 --> 00:49:58,610
+الرجال أو عند الذكور بسبب أنه it is X-linked
+
+456
+00:49:58,610 --> 00:50:03,350
+recessive والـFrequency تبعته هي 8 بالمينيو لو
+
+457
+00:50:03,350 --> 00:50:12,710
+سألنا شو نسبةإذا هي الـ Frequency للقليل 92% يعني
+
+458
+00:50:12,710 --> 00:50:16,810
+هي Polymorphism نعتبرها Mutation، هي ليست
+
+459
+00:50:16,810 --> 00:50:21,130
+ميوتاشيا، نعتبرها شيء موجود وبالـ Steady State
+
+460
+00:50:21,130 --> 00:50:28,230
+موجود بهذه النسبة شو نثبت إن أنت تكون Color Blind؟
+
+461
+00:50:28,230 --> 00:50:37,390
+فرح نقول 8% تربية، اللي هي 64 من 10000ماشي يعني
+
+462
+00:50:37,390 --> 00:50:45,930
+حوالي 0.05% مثلا 0.06% أو 0.01% يعني اللي هو نسبة
+
+463
+00:50:45,930 --> 00:50:53,470
+هذه يعني اللي هي هاي بتعطينا اللي … اللي يكون
+
+464
+00:50:53,470 --> 00:50:59,370
+female الـ not completely normal homozygous normal
+
+465
+00:50:59,370 --> 00:51:06,320
+راح يكون 0.9التربيه اللي هو المسبة هذه اللي هتكون
+
+466
+00:51:06,320 --> 00:51:11,760
+Carrier فيه Normal Heterozygous أو Combined Normal
+
+467
+00:51:11,760 --> 00:51:19,260
+Heterozygous اللي هو 2PQ بتكون هالجدة وNormal اللي
+
+468
+00:51:19,260 --> 00:51:28,180
+هو Combined بتلاقي يعني شو اللي هنا بيحكوه لما أنا
+
+469
+00:51:28,180 --> 00:51:34,960
+آجي على مستوى الـGene Frequencyالـ الـ الـ الـ الـ
+
+470
+00:51:34,960 --> 00:51:35,200
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+471
+00:51:35,200 --> 00:51:35,300
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+472
+00:51:35,300 --> 00:51:35,640
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+473
+00:51:35,640 --> 00:51:36,260
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+474
+00:51:36,260 --> 00:51:44,820
+الـ الـ الـ الـ الـ الـ الـ الـ
+
+475
+00:51:44,820 --> 00:51:48,600
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+476
+00:51:48,600 --> 00:51:48,620
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+477
+00:51:48,620 --> 00:51:50,400
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+478
+00:51:50,400 --> 00:51:50,520
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+479
+00:51:50,520 --> 00:51:56,100
+الـ الـ
+
+480
+00:51:56,100 --> 00:52:04,850
+الـفاللي هو بيكون نسبته 2PQ اللي هو 0.147 الـ
+
+481
+00:52:04,850 --> 00:52:09,130
+«morphologically» أو الـ «phenotypically» «normal»
+
+482
+00:52:09,130 --> 00:52:12,990
+هو هذه المجموعة زائد هذه المجموعة فتجمع هذول
+
+483
+00:52:12,990 --> 00:52:19,750
+الرقمين بيطلع 0.9936% يعني راح يطلع لك الرقم هذا،
+
+484
+00:52:19,750 --> 00:52:23,930
+مجموع هاي زائد هاي والـ «colorblind» بالـ «female»
+
+485
+00:52:24,820 --> 00:52:31,660
+اللي راح تكون Q تغبيع اللي هو راح يطلع على فرق جدا
+
+486
+00:52:31,660 --> 00:52:38,220
+فهذا المثال يعني لما نيجي ناخد بالنسبة كـ Male لـ
+
+487
+00:52:38,220 --> 00:52:44,180
+X-linked recessive genotype لما ناخدها راح تكون
+
+488
+00:52:44,180 --> 00:52:47,920
+الـ frequency هي الـ frequency تبعت الـ genes في
+
+489
+00:52:47,920 --> 00:52:54,460
+الـ population 0.92% و0.08% راح أشوف إشي زي ذلك
+
+490
+00:52:55,280 --> 00:53:04,500
+ماشي فهذا مثال برضه على استخدام التعقيدات بالنسبة
+
+491
+00:53:04,500 --> 00:53:12,000
+للموضوع هذا على افتراض أولاً إنه الـ Hardy
+
+492
+00:53:12,000 --> 00:53:17,960
+-Weinberg equation أو law اللي هو بيفترض إن الـ
+
+493
+00:53:17,960 --> 00:53:22,360
+population stable الـ mutation مافيش إشي زديد
+
+494
+00:53:22,360 --> 00:53:28,110
+مافيش migrationالـ Mating مسموح بيه بين كل الأفراد
+
+495
+00:53:28,110 --> 00:53:37,470
+بشكل طبيعي فيها أسئلة؟
+
+496
+00:53:37,470 --> 00:53:42,410
+الآن لما
+
+497
+00:53:42,410 --> 00:53:49,550
+نقول إن زي المشكلة قبل شوية اللي هي أو الملاحظة
+
+498
+00:53:49,550 --> 00:53:54,960
+قبل شوية اللي هولو أخذنا الـ Color Vision
+
+499
+00:53:54,960 --> 00:54:02,480
+Blindness أو عمل ألوان أو Normal Vision، ماشي؟ هذه
+
+500
+00:54:02,480 --> 00:54:09,940
+ظاهرة Very Frequently وموجودة ولمّا بلاقيها موجودة
+
+501
+00:54:09,940 --> 00:54:18,620
+عند الناس، ماشي؟ بلاقيها كـ يعني على أساس إنه حتى
+
+502
+00:54:18,620 --> 00:54:23,620
+اللي عنده Color Blindnessبإمكانه يتزاوج وبإمكانه
+
+503
+00:54:23,620 --> 00:54:29,020
+يخلف وما بتأثرش في حياته وبقيش تقريبًا حياة طبيعية
+
+504
+00:54:29,020 --> 00:54:34,040
+يعني بس شوية صعوب أنه يفرق بين الأحمر والأخضر ولا
+
+505
+00:54:34,040 --> 00:54:41,240
+بين اللونين ولا كذا ولا هيك في أحيانًا نتكلم على
+
+506
+00:54:41,240 --> 00:54:44,780
+الأمراض
+
+507
+00:54:44,780 --> 00:54:53,720
+اللي نتيجة المرض بكون أنهالـ «جين» هذا ما راح يكمل
+
+508
+00:54:53,720 --> 00:55:01,060
+يعني أنا بالنسبة لي هدولا حاطين مجموعة إمراض شكل
+
+509
+00:55:01,060 --> 00:55:08,320
+معين بس «استيوجينيساس إمبرفكتر» هذا مرض كان عندنا
+
+510
+00:55:08,320 --> 00:55:12,960
+و أنا كنت طالب طب في مستشفى مبارك في الكويت كانت
+
+511
+00:55:12,960 --> 00:55:19,320
+مريضة مقيمة في المستشفى عندها هشاش سديدي جدا جدا
+
+512
+00:55:19,320 --> 00:55:26,350
+في العظاميعني مجرد مرات تقح، بنكسر العظيم تشدها أو
+
+513
+00:55:26,350 --> 00:55:31,810
+تسلم عليها بيدك بقوة، بنكسر العظيم فعندها شاشة
+
+514
+00:55:31,810 --> 00:55:36,730
+شديدة في العبام المريضة كان يمكن عمرها 25 سنة
+
+515
+00:55:36,730 --> 00:55:44,190
+طبعاً الملاحظ إلها إذا بتفرجيكم صور إلها لهذه
+
+516
+00:55:44,190 --> 00:55:49,750
+الحالة Astrogenesis imperfecta بتلاقي لون العيون
+
+517
+00:55:49,750 --> 00:55:57,740
+زرقالبياض العين، يعني خلّينا نفرجيكم صورتها
+
+518
+00:55:57,740 --> 00:56:05,500
+أستيوجينيــــــــــــــــــــــ
+
+519
+00:56:42,760 --> 00:56:51,580
+فمريضتي إذا شايفين الصورة هذه معاي شايفينها هي
+
+520
+00:56:51,580 --> 00:56:56,890
+يمكن امرأة عمرهاعشرين ثانية وخمسة وعشرين ثانية على
+
+521
+00:56:56,890 --> 00:57:05,910
+wheelchair بهذا الشكل وعظامها مكسرة وكيبوسكوليوسيس
+
+522
+00:57:05,910 --> 00:57:12,290
+العظام بشكلها مش مظبوط وبتكون بشكل تعبان كتير
+
+523
+00:57:12,290 --> 00:57:16,390
+فالفكرة اللي
+
+524
+00:57:24,470 --> 00:57:32,050
+الفكرة أنه لما نكون مرض بالمثل هذه الحالة شو
+
+525
+00:57:32,050 --> 00:57:39,230
+احتمالية لو أنا عند الـ P و الـ Q وعندي
+
+526
+00:57:39,230 --> 00:57:44,970
+نسب لهذه الجينات في المجتمع ماشي، شو نسبتها
+
+527
+00:57:44,970 --> 00:57:49,430
+بالنسبة للمرض هذا؟ في حد بيقدر يقوللي؟
+
+528
+00:58:06,380 --> 00:58:15,160
+الـ على افتراض أنه هذا الـ يعني النقطة اللي بده
+
+529
+00:58:15,160 --> 00:58:23,040
+يصلها في الموضوع هذا اللي هي موضوع أن حدوث هذه
+
+530
+00:58:23,040 --> 00:58:29,760
+الطفرة بهذا الشكل وتواجدها في الإنسان بيكون
+
+531
+00:58:29,760 --> 00:58:39,650
+أحيانًا lethal type يعنيويكون مميت فالاستنتاج
+
+532
+00:58:39,650 --> 00:58:47,730
+من أن هذه الأمراض عبارة عن أمراض قاتلة خصوصًا
+
+533
+00:58:47,730 --> 00:58:52,370
+أحيانًا كثيرة زي الـ Chromosome of anomalies حتى
+
+534
+00:58:52,370 --> 00:58:56,290
+بالكون بالـ Embryon كثير من الـ Lethal وما بيكملش
+
+535
+00:58:56,290 --> 00:59:02,790
+في الجنين الأنواع من المشاكل هذه بالأخير راح تكون
+
+536
+00:59:03,280 --> 00:59:08,820
+كلها نتيجة تفرات جديدة عم تحدث في المجتمع يعني
+
+537
+00:59:08,820 --> 00:59:16,540
+high disorders لسبب إنه المصاب بهذه الحالة ما في
+
+538
+00:59:16,540 --> 00:59:21,780
+مجال إنه يتزوج بحيث يعطي، ينقل هذا المرض للأبناء
+
+539
+00:59:21,780 --> 00:59:25,640
+والبنات تبعيه فالـFrequency اللي بنحكي عنها الـD
+
+540
+00:59:25,640 --> 00:59:33,280
+والـQ والنسب هذه ما تنطبق هنا والسبب إنهما في مجال
+
+541
+00:59:33,280 --> 00:59:40,020
+إن هاي الحالة تكون نتيجة ورافة من الأب والأم لأن
+
+542
+00:59:40,020 --> 00:59:44,840
+ما في إنسان عنده هذا المرض وصل إنه يكون أب أو أم
+
+543
+00:59:44,840 --> 00:59:52,420
+يكون يقدر يتزوج أو حد يتزوجه، واضح؟ فأحياناً الـ
+
+544
+00:59:52,420 --> 01:00:01,140
+«هاي» لما يعني القصة اللي بدرسوها بالنسبة للموضوع
+
+545
+01:00:01,140 --> 01:00:07,930
+هذااللي هو بيسموه الـ Fitness اللي هو إنه هل هاي
+
+546
+01:00:07,930 --> 01:00:15,230
+الحالة أو المرض أو الشغل بتأثر على أهليته للزواج
+
+547
+01:00:15,230 --> 01:00:20,170
+على رغبة البشر الآخرين إنه يتزوجوهوا بتزوجوا منه
+
+548
+01:00:20,170 --> 01:00:26,470
+أو يزوجوه أو يتزوجها فلما يكون في عندي condition
+
+549
+01:00:26,470 --> 01:00:33,570
+بـ Zero Fitness يعني ما في احتمالية إنهبعد إصابة
+
+550
+01:00:33,570 --> 01:00:39,050
+إنسان بهذا المرض أو ولادته فيه لأنه مرض وراثي ما
+
+551
+01:00:39,050 --> 01:00:44,950
+في احتمالية إن هذا يكون ناقل للمرض بعدين لأن ماحدة
+
+552
+01:00:44,950 --> 01:00:53,810
+بيزوجوا بعدين يعني فهذه ظاهرة أخرى لما نشوف مثل
+
+553
+01:00:53,810 --> 01:01:00,170
+هذه نسبة احتمالية هذا المرض فهو نسبة يعني معتمد
+
+554
+01:01:00,170 --> 01:01:07,630
+على نسبةتكوّن ونشوء New Mutation لأنه ما في مجال
+
+555
+01:01:07,630 --> 01:01:15,490
+أن يكون نتيجة Transmission of الجين للأولاد
+
+556
+01:01:15,490 --> 01:01:24,050
+والبنات لأنه Lethal لأنه ما بيكون ممكن أنه ينقل
+
+557
+01:01:24,050 --> 01:01:31,130
+الـCCR5 Delta اللي هو الـMutation هذه ما أثرت على
+
+558
+01:01:31,130 --> 01:01:36,590
+واحدالـ Color Blindness كمثال آخر بالـ Males ولا
+
+559
+01:01:36,590 --> 01:01:42,310
+الـ Females وكذا برضه مش مأثرة الـ Blood Group مش
+
+560
+01:01:42,310 --> 01:01:48,310
+مأثرة يعني ما بتأثر على الـ Fitness تبع الإنسان
+
+561
+01:01:48,310 --> 01:01:59,590
+للزواج ونقل الوراتق للأبناء والبنات بعد ذلك يعني
+
+562
+01:02:00,870 --> 01:02:08,590
+التطبيق الآخر، في أسئلة؟
+
+563
+01:02:08,590 --> 01:02:15,330
+التطبيق
+
+564
+01:02:15,330 --> 01:02:19,170
+الآخر للمعلومات
+
+565
+01:02:19,170 --> 01:02:27,930
+هذه اللي هي أنك أنت لما تدرس قداش، نسب، أي شيء
+
+566
+01:02:28,700 --> 01:02:33,640
+بتلاقي يعني
+
+567
+01:02:33,640 --> 01:02:42,000
+بتلاقي معلومات تكون مفيدة كالطب ومجتمع وكيف ده
+
+568
+01:02:42,000 --> 01:02:48,300
+تتعامل مع الكثير من الأشياء فالنقطة التالية
+
+569
+01:02:48,300 --> 01:02:55,900
+بالنسبة لك مواضيع إنه حكينا عن الـV والـQ وكذابدأ
+
+570
+01:02:55,900 --> 01:03:02,780
+تكون في population معينة تكون في مجموعة معينة
+
+571
+01:03:02,780 --> 01:03:09,260
+أحيانًا الصورة اللي أخذناها قبل شويه لـEuropa وكذا
+
+572
+01:03:09,260 --> 01:03:19,180
+على اعتبار أنه كل بشر في مكان معين يعني مافيش
+
+573
+01:03:19,180 --> 01:03:26,150
+هالـMigration كتير، كل واحدبتزوجوا من بعض بخطوط
+
+574
+01:03:26,150 --> 01:03:32,110
+شويه فيه نوع من الـ isolation وهي يعني غصب عنها
+
+575
+01:03:32,110 --> 01:03:38,750
+أحيانًا بتحدث يعني مثلًا في أمريكا مثلًا بيتكلموا
+
+576
+01:03:38,750 --> 01:03:42,730
+على إن الأمريكان السود إيش إلهم؟ إيش الأمريكان
+
+577
+01:03:42,730 --> 01:03:48,050
+البيض؟ إلهم وراثة معينة؟ الأمريكان الأصليين
+
+578
+01:03:48,050 --> 01:03:54,380
+الهولود الحمر؟ إلهم إشي ثالث؟يعني حتى على مستوى
+
+579
+01:03:54,380 --> 01:04:00,600
+مرات يعني أنا مثلاً في أي مكان مثلاً في الأردن
+
+580
+01:04:00,600 --> 01:04:07,200
+نتلاقي مثلاً نتكلم والله العيل الأفلاني مثلاً
+
+581
+01:04:07,200 --> 01:04:12,400
+مفشور عندهم مثلاً في مثلاً
+
+582
+01:04:12,400 --> 01:04:19,830
+في حالة اللي بيسموهاتحسس من المواد المخدرة تبع الـ
+
+583
+01:04:19,830 --> 01:04:26,450
+General Anesthesia فالـ General Anesthesia Agents
+
+584
+01:04:26,450 --> 01:04:31,290
+أحيانًا بتسبب حالة شديدة جدًا جدًا وخطيرة جدًا ففي
+
+585
+01:04:31,290 --> 01:04:37,490
+عائلة معينة معروفين عنها في البلد وفي بالذات يعني
+
+586
+01:04:37,490 --> 01:04:41,550
+في منطقتنا وهدولة آه واللههذه العيلة عندهم الحالة
+
+587
+01:04:41,550 --> 01:04:46,530
+الإفلانية لما تعطيهم تخدير بدك تكون حذر جداً وبدك
+
+588
+01:04:46,530 --> 01:04:51,250
+تأخذ احتياطات وبدك تعمل كذا أحياناً إنك تعرف إن ال
+
+589
+01:04:51,250 --> 01:04:55,690
+population اللي أنت بتتعامل معها عندها حالة معينة
+
+590
+01:04:55,690 --> 01:05:01,870
+بيكون هذا قضية مهمة فالآن ناخد بعض الأمثلة لخمسة
+
+591
+01:05:02,170 --> 01:05:13,210
+طفرات أو خمس حالات أو شو اسمه بالنسبة لخمس أمراض
+
+592
+01:05:13,210 --> 01:05:20,170
+الأول اللي هو Sickle Cell Anemia الـSS Genotype
+
+593
+01:05:20,170 --> 01:05:27,330
+يعني خدوس أو وجود مرض Sickle Cell بالنسبة
+
+594
+01:05:27,330 --> 01:05:37,610
+لهنا حاطينالـ بالنسبة للـ African Americans
+
+595
+01:05:37,610 --> 01:05:44,570
+الأفارقة الأمريكان الأفارقة من أصول أفريقية الـ SS
+
+596
+01:05:44,570 --> 01:05:52,510
+Hemoglobin تقريبًا نسبته واحد في كل 400 شخص هذه
+
+597
+01:05:52,510 --> 01:05:59,770
+النسبة ماشي وعندما تيجي تأكسها يعني هي تمثل الـ
+
+598
+01:05:59,770 --> 01:06:07,680
+الـالـ Q تربيع فالـ هو أنا عشرين من عشرين يعني
+
+599
+01:06:07,680 --> 01:06:16,620
+واحد من العشرين من كل العشرين أمريكي
+
+600
+01:06:16,620 --> 01:06:22,240
+أفريقي من أصول أفريقية اللي عنده الـ Sickle Cell
+
+601
+01:06:22,240 --> 01:06:27,340
+Trait أو القليل فواحد من عشرين تطلع خمس بالمية
+
+602
+01:06:27,340 --> 01:06:35,860
+فالـ Q خمس بالميةوعشان هيك بيطلع واحد في اللي هو
+
+603
+01:06:35,860 --> 01:06:43,420
+من كل 400 بس من ناحية الثانية كام نسبة الـ
+
+604
+01:06:43,420 --> 01:06:52,160
+carriers لهذا الجين اللي هو 5%؟ راح تكون 25% في 95
+
+605
+01:06:52,160 --> 01:07:01,750
+% راح تطلع تقريباً 0.9 اللي هي راح تطلعواحد كل
+
+606
+01:07:01,750 --> 01:07:09,590
+أحداشر هذه النسبة على إذا أخذنا الـ Steady State
+
+607
+01:07:09,590 --> 01:07:17,670
+الـ Hardy-Weinberg Equation بنسبة نسبة حدوث المرض
+
+608
+01:07:17,670 --> 01:07:25,490
+ونسبة القليل الصورة
+
+609
+01:07:25,490 --> 01:07:30,670
+الموجودةأو الـGene الموجود، وشو نسبة قدوته وشو
+
+610
+01:07:30,670 --> 01:07:37,870
+نسبة اللي هي الـHeterozygous يعني اللي عندهم نسبة
+
+611
+01:07:37,870 --> 01:07:44,130
+الـCarrier يعني هو لنا بدا تكون اللي هم الواحد في
+
+612
+01:07:44,130 --> 01:07:51,910
+الـ11 بينما لمنطقة قريبة أو لمجموعة قريبة في
+
+613
+01:07:51,910 --> 01:07:58,650
+أمريكا اللي هم الـHispanics من أصولحسب أسبانية ومن
+
+614
+01:07:58,650 --> 01:08:07,610
+أصول يعني مختلفة من مش أفريقا، مش أفارقة النسبة
+
+615
+01:08:07,610 --> 01:08:14,450
+واحد في كل 40 ألف ونسبة الأليل frequency 0.005
+
+616
+01:08:14,450 --> 01:08:21,170
+ونسبة إن واحد يكون career 1% نسب أندر بكثير إنه
+
+617
+01:08:21,170 --> 01:08:27,750
+علاقة إنسان Hispanic في أمريكايكون Sickle Cell على
+
+618
+01:08:27,750 --> 01:08:32,510
+عكس الأفارقة فيه كلام كتير شوه همية الـ SS
+
+619
+01:08:32,510 --> 01:08:36,830
+-Hemoglobin وإنه كيف إن الـ «هيتروزايجست» تبعه
+
+620
+01:08:36,830 --> 01:08:41,710
+بيخلّي الإنسان مقاوم للملاريا وليش الأفارقة عنده
+
+621
+01:08:41,710 --> 01:08:46,770
+دي بالنسبة أكبر على أساس إن المناطق اللي كانوا
+
+622
+01:08:46,770 --> 01:08:51,390
+عايشين فيها فيها ملاريا كتيرة وهذا بيعطيك نوع من
+
+623
+01:08:51,390 --> 01:08:58,330
+المقاوم للملاريافالـ «high» لمثال الـ Sickle Cell
+
+624
+01:08:58,330 --> 01:09:04,190
+Anemia هيك الأقام بتقول فما جابوش نسبة الـ «white»
+
+625
+01:09:04,190 --> 01:09:11,310
+قداش وحتى الواحد يشوف بس فيه يعني على الأقل مئة
+
+626
+01:09:11,310 --> 01:09:17,030
+ضعف فرق بالنسبة لـ Sickle Cell Anemia بين الأفريقا
+
+627
+01:09:17,030 --> 01:09:25,150
+وبين الهسباني منينيجي ناخد على الـ Rhاللي هو All
+
+628
+01:09:25,150 --> 01:09:32,190
+Rh Negative Alleles هنا الـ Rh، بدكم تتذكروا إن
+
+629
+01:09:32,190 --> 01:09:38,550
+الـ Rh زي الـ ABO System PA وB وO الـ Rh هو ثلاث
+
+630
+01:09:38,550 --> 01:09:43,890
+جينات مترابطة الـ C والـ D والـ E وأهم واحد هو الـ
+
+631
+01:09:43,890 --> 01:09:52,730
+D لما نعطي الـ لما نعطيالمرأة الحامل لما راح
+
+632
+01:09:52,730 --> 01:09:57,190
+ناخذها الـ Rh-incompatibility باجي بعطيهم mainly
+
+633
+01:09:57,190 --> 01:10:02,990
+Anti-D لأن أهم واحد هو الـD فلما
+
+634
+01:10:02,990 --> 01:10:07,610
+درسوا الموضوع هذا يكون
+
+635
+01:10:07,610 --> 01:10:14,850
+الـRh نيجاتيف للكل اللي هو واحد لسته أقل تمثل اللي
+
+636
+01:10:14,850 --> 01:10:21,030
+هي يعني أحنا تقريباً كنا بيقول واحد لعشربالمتوسط
+
+637
+01:10:21,030 --> 01:10:24,850
+يعني أنا كنت أقول الـ Rh إن الواحد يكون Negative
+
+638
+01:10:24,850 --> 01:10:34,550
+هو احتمالية العشر فبالنسبة للـ Whites 1 في 6 نسبية
+
+639
+01:10:34,550 --> 01:10:39,590
+عالية في الـ African Americans 1 في 14 ممكن
+
+640
+01:10:39,590 --> 01:10:44,810
+مجموعهم يكون 1 ل 10 تقريباً بينما عند اليابانيين
+
+641
+01:10:44,810 --> 01:10:49,070
+أو اليابانيات أو اليابانيين 1 في 200
+
+642
+01:10:51,800 --> 01:10:58,260
+فإنما ناخد الـ Frequency للـ Heterozygous اللي هو
+
+643
+01:10:58,260 --> 01:11:02,500
+2PQ اللي هو في نهاية بالنسبالي يعني بيكون الإنسان
+
+644
+01:11:02,500 --> 01:11:08,540
+Carrier تقريبًا نص بالنسبة للـ African Americans
+
+645
+01:11:08,540 --> 01:11:16,820
+40% Carrier بينما اليابانيين 1 في 8 تقريبًا 1 في
+
+646
+01:11:16,820 --> 01:11:25,250
+10 يعني تقريبًافهذه نسب للـ Rh الـ Phenylketonuria
+
+647
+01:11:25,250 --> 01:11:30,910
+مرض ويراثي بالـ Metabolism يكون فيه نقص في إنزين
+
+648
+01:11:30,910 --> 01:11:36,150
+معين يخليهم يتسمموا من الـ Phenylalanine الـ Amino
+
+649
+01:11:36,150 --> 01:11:43,230
+Acid بيعمل preventable mental retardationيعني هذا
+
+650
+01:11:43,230 --> 01:11:48,250
+أنا في الأردن عضو في جمعية الـ جمعية الأردنية الـ
+
+651
+01:11:48,250 --> 01:11:55,250
+Phenylketonuria يعني عبارة عن مرض يعني الصراحة
+
+652
+01:11:55,250 --> 01:12:04,230
+عنده يعني احتكاك فيه يعني تقريباً عندنا واحد في
+
+653
+01:12:04,230 --> 01:12:11,130
+الـ 3000 بني آدم عنده Phenylketonuria إذا تمتشخيصه
+
+654
+01:12:11,130 --> 01:12:16,670
+بشكل مبكر وبشكل سليم وبطل ليأكل الخبز العادي
+
+655
+01:12:16,670 --> 01:12:20,930
+والبروتين العادي وعطيته Special Diet بعيش طبيعي
+
+656
+01:12:20,930 --> 01:12:26,410
+ويبنمه طبيعي ويكون طبيعي أما إن إذا انترك راح يكون
+
+657
+01:12:26,410 --> 01:12:34,750
+نتيجته إنه عنده Mental Retardation فالنسب إذا
+
+658
+01:12:34,750 --> 01:12:39,570
+بنشوففي سكوتلاندا، إحنا عندنا في الأردن بيقدروا
+
+659
+01:12:39,570 --> 01:12:47,210
+واحد في التلات تلات أي تقديراً فلما نشوف قداش نسب
+
+660
+01:12:47,210 --> 01:12:51,930
+للـ Incidents واحد بالخمس تلات، واحد بالمائتين ألف
+
+661
+01:12:51,930 --> 01:12:55,410
+في فنلاندا وواحد بالمائة وعشرة تلات تقريبا في
+
+662
+01:12:55,410 --> 01:13:02,650
+اليابان هنا بتمثل الأليل frequency ونسبة الـ
+
+663
+01:13:02,650 --> 01:13:07,080
+carriers يعنيفسكوتلاندا تقريبًا واحد في الأربعين
+
+664
+01:13:07,080 --> 01:13:13,160
+في فنلاندا واحد في الـ250 اليابان واحد في الـ150
+
+665
+01:13:13,160 --> 01:13:21,140
+تقريبًا 160 فهذه للـRecessive Disorders وهنا
+
+666
+01:13:21,140 --> 01:13:27,960
+الـRecessive Disorders أوضح بالنسبة لأنها كلها
+
+667
+01:13:27,960 --> 01:13:33,770
+Recessive Disorders وبتكون يعني الـالـ Q تربية هي
+
+668
+01:13:33,770 --> 01:13:39,010
+نسبة الحدوث للـ Disease لأن هذا اللي بدي يكون عنده
+
+669
+01:13:39,010 --> 01:13:46,050
+Two copies which are يعني effective بالنسبة
+
+670
+01:13:46,050 --> 01:13:49,170
+لبعض الـ Other diseases زي الـ «فاميلة
+
+671
+01:13:49,170 --> 01:13:53,810
+الهيبركوليستروليميا» و «myotonic dystrophy» الـ
+
+672
+01:13:53,810 --> 01:13:56,090
+«myotonic dystrophy»، «فاميلة الهيبركوليستروليميا»
+
+673
+01:13:56,090 --> 01:13:59,890
+واحد من هذه الـ «hyperlipidemias» وهذه الأرقام
+
+674
+01:13:59,890 --> 01:14:08,570
+عندكموالـ Myotonic Dystrophy اللي هو تشنج العضلات
+
+675
+01:14:08,570 --> 01:14:14,710
+ويكون خلل في العضلات تظلها مضطرة يعني مافيش
+
+676
+01:14:14,710 --> 01:14:21,090
+relaxation للعضلة النقطة وما فيها أنه اللي راح
+
+677
+01:14:21,090 --> 01:14:26,770
+أشوفه من عنده disease ماشي من هذا النوع لأن هذا
+
+678
+01:14:26,770 --> 01:14:35,280
+صفة ساعدة فهوالـ «Q» تربية نسبة الأليل المصاب
+
+679
+01:14:35,280 --> 01:14:40,180
+ونسبة الـ heterozygous مع بعض يعني هذه الـ
+
+680
+01:14:40,180 --> 01:14:48,220
+frequency اللي راح أشوفها تتمثل هذه الاحتمالية
+
+681
+01:14:48,220 --> 01:14:54,320
+فأنا لما نشوف مثلا واحد في كل 25 ألف أو واحد في كل
+
+682
+01:14:54,320 --> 01:14:57,970
+500 تقريبًاولا بالنسبة لـ Family of
+
+683
+01:14:57,970 --> 01:15:04,250
+Hypercholesterolemia واحد في السبعين في أفريقيا أو
+
+684
+01:15:04,250 --> 01:15:08,270
+في أمريكا واحد في الخمسمائة أو في كيندا واحد في
+
+685
+01:15:08,270 --> 01:15:18,330
+الـ122 فهذه النسب المتوقعة للقليل تبع الـDisease
+
+686
+01:15:18,330 --> 01:15:27,720
+تكون بهذا الشكل فيعني الأمريعني أحيانًا لما واحد
+
+687
+01:15:27,720 --> 01:15:32,020
+يتعامل مع الطب في population معينة بهمه يعرف إذا
+
+688
+01:15:32,020 --> 01:15:37,300
+فيه مميز لهم إذا فيه احتمالية أكبر لبعض الأمراض
+
+689
+01:15:37,300 --> 01:15:45,560
+أكتر من أمراض تانية والأصل الوزارة الصحية والمسح
+
+690
+01:15:45,560 --> 01:15:53,720
+الطبي والمسح الصحي في منطقة معينةإنه يكون على
+
+691
+01:15:53,720 --> 01:16:02,300
+انتباه لهذه الأمراض ونسبها ويكون يعني تصور لوجودها
+
+692
+01:16:02,300 --> 01:16:08,120
+وبالتالي يعني بيخلّي القطاع الصحي منتبه أكتر لشغل
+
+693
+01:16:08,120 --> 01:16:11,820
+عملته طريقة
+
+694
+01:16:11,820 --> 01:16:18,900
+يعني استفادة أخرى من هذا الموضوع هي قضية
+
+695
+01:16:21,530 --> 01:16:30,790
+في أسئلة على اللي تم من قبل؟ في أي استفسار؟
+
+696
+01:16:30,790 --> 01:16:39,230
+أموركم كويسة؟
+
+697
+01:16:39,230 --> 01:16:41,250
+طيب، نكمل
+
+698
+01:16:45,000 --> 01:16:53,100
+في سؤال من كريم بيقول الأرقام والنسب مش حفظ يعني
+
+699
+01:16:53,100 --> 01:16:58,060
+مطلوب فاهم كيف أجت وشو بنفهم منها بس طبعا، طبعا،
+
+700
+01:16:58,060 --> 01:17:04,480
+طبعا، ويعني النقطة الحقيقية المطلوبة من هذه
+
+701
+01:17:04,480 --> 01:17:09,550
+الأرقامقضية تفاوتها في نفس المجتمع يعني في المجتمع
+
+702
+01:17:09,550 --> 01:17:14,930
+الأمريكي والله نسبة الـ Sickle Cell لو كان إنسان
+
+703
+01:17:14,930 --> 01:17:20,130
+أبيض ولا أسود ولا أمريكي أصلي ولا كده كيف إنها أو
+
+704
+01:17:20,130 --> 01:17:28,390
+Hispanic population هذه ناحية مهمة وهذه بالنسبة
+
+705
+01:17:28,390 --> 01:17:37,310
+لهم ماشيةيعني أحيانًا إليها دخل بنسميه بالطب
+
+706
+01:17:37,310 --> 01:17:43,910
+الشخصي Personalized Medicine بصير أنا هنا من
+
+707
+01:17:43,910 --> 01:17:50,290
+المعلومات السابقة عن نسبة خدوث المرض الإفلاني في
+
+708
+01:17:50,290 --> 01:17:56,010
+المجموعة الإفلانية بتخليني أتنبأ أو أعرف جزء من
+
+709
+01:17:56,420 --> 01:18:01,280
+سواء نوعية المرض اللي عنده شدة المرض اللي عنده
+
+710
+01:18:01,280 --> 01:18:05,200
+احتمالية المرض اللي عنده فهذه أحيانًا معلومات
+
+711
+01:18:05,200 --> 01:18:08,920
+مفيدة جدًا وأحيانًا تستخدم حتى على مستوى الشخص
+
+712
+01:18:08,920 --> 01:18:15,260
+ماشي أنه إيش يعني في أمريكا مثلًا من الأشياء اللي
+
+713
+01:18:15,260 --> 01:18:21,380
+دائمًا بيسألوا عنها ويعني بيركزوا عليها قضية شو
+
+714
+01:18:21,380 --> 01:18:27,090
+أصولهاكوخازي يعني أبيض، احنا طبعاً البيض، العرب
+
+715
+01:18:27,090 --> 01:18:32,030
+بيعتبرونا كوخازيين يعني لما ناخد التصنيف، بس مش
+
+716
+01:18:32,030 --> 01:18:40,130
+أفريقي، مش هسباني أو إسباني، يعني مش طبعاً أصول
+
+717
+01:18:40,130 --> 01:18:46,610
+الصينية، Orientals، أصول هندية، مثلاً، بدك تشوف في
+
+718
+01:18:46,610 --> 01:18:53,240
+أي ناحية أحياناً مهمة في قضية توقعك للمرضماشي
+
+719
+01:18:53,240 --> 01:19:00,740
+دايمًا الأرقام ما هي يعني المهم فهم العلاقات بينها
+
+720
+01:19:00,740 --> 01:19:06,680
+وليش هي أجت وشو بتمثل ماشي أكثر من إنه شو هو الرقم
+
+721
+01:19:06,680 --> 01:19:18,920
+نفسه يعني إذا أنا أعطيتك مثلًا disease disease
+
+722
+01:19:18,920 --> 01:19:24,550
+recessiveوأعطيتك مثلًا إنه بيصيرك واحد من عشرة من
+
+723
+01:19:24,550 --> 01:19:31,850
+الـ population تقدر تجيب الـ Q إذا واحد من العشرة
+
+724
+01:19:31,850 --> 01:19:36,670
+من ال population عنده الـ disease، ماشي؟ فإذا
+
+725
+01:19:36,670 --> 01:19:38,470
+العشر هو
+
+726
+01:19:38,470 --> 01:19:45,730
+اللي’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’
+
+727
+01:19:49,770 --> 01:19:59,310
+هنا لما يكون مثلا 1 في الأربعمية معناته لو أخذناها
+
+728
+01:19:59,310 --> 01:20:06,290
+نسبة راح تطلع 1 بالعشرين ماشي لأنه الـ 1 في
+
+729
+01:20:06,290 --> 01:20:11,290
+العشرين إذا نسبة القليل في الـ population بيخليني
+
+730
+01:20:11,290 --> 01:20:16,290
+إن المصابين 1 بالأربعمية نسبة الـ carriers إذا 0
+
+731
+01:20:16,290 --> 01:20:26,260
+.05%اللي هي راح تطلع كنسبة Career 0.1 اللي هي 2PQ
+
+732
+01:20:26,260 --> 01:20:32,480
+ناشي، لما أضربن بعض النسب المفروض أطلق أرقام زي
+
+733
+01:20:32,480 --> 01:20:38,720
+هذه أظن يعني مش غلط أنه جدول زي هيك الواحد يقعد
+
+734
+01:20:38,720 --> 01:20:44,230
+يطلع مثلا شو نسبة الـPمثلاً لو هيك نخدها exercise
+
+735
+01:20:44,230 --> 01:20:49,190
+بعدين ونطلق نسبة الـP تبعت ال population تبعت
+
+736
+01:20:49,190 --> 01:20:53,330
+الأليل الأصلي أو اللي هو اللي مش مصارف دكتور في
+
+737
+01:20:53,330 --> 01:20:59,110
+سؤال سؤالين حتى في سؤال من معتز بيسأل كيف ال
+
+738
+01:20:59,110 --> 01:21:02,910
+career أجى يعني P كام نسبة يعني كيف ال career أجى
+
+739
+01:21:02,910 --> 01:21:07,670
+يعني بيسأل P كانت كام نسبتها مش مكتوبمش عارف إذا
+
+740
+01:21:07,670 --> 01:21:14,830
+كان جزده على الـ slide السابق اسمعلي، الآن
+
+741
+01:21:14,830 --> 01:21:22,710
+لما تيجي تاخد انت القاعد الأولى بالنسبة لل
+
+742
+01:21:22,710 --> 01:21:32,870
+equation ماشي أن الـ P زادي بـQ يسوى كم؟ يسوى واحد
+
+743
+01:21:32,870 --> 01:21:42,220
+فهم عليك إيه؟أنت لما تيجي تأخذ لك 100 بني آدم كام
+
+744
+01:21:42,220 --> 01:21:49,700
+نسخة من الجين راح تلاقي؟ راح فيه، عندي 200 نسخة،
+
+745
+01:21:49,700 --> 01:21:56,340
+صح؟ فأنا عندي 200 نسخة من الجين اللي هو زي «CCR»
+
+746
+01:21:56,340 --> 01:22:02,420
+سواء الـ «5» الأصلي أو الـ «Mutated» نفترض هيك،
+
+747
+01:22:02,420 --> 01:22:11,350
+صح؟فلما أنا عندي 200 نسخة أخدتها من 180 أدم ماشي،
+
+748
+01:22:11,350 --> 01:22:19,370
+نسبة هذا الـ Disease أو الـ Normal هذولا النسبتين
+
+749
+01:22:19,370 --> 01:22:25,370
+مجموعهم 100 أو 1 آسف، راح يكون مجموعهم 1 فلما أنا
+
+750
+01:22:25,370 --> 01:22:29,190
+أخد إن الـ P، الـ Q هنا Zero مثلا زي الـ Sickle
+
+751
+01:22:29,190 --> 01:22:35,880
+Cell في الـ African Americansالنتيجة هي 0.05 هذا
+
+752
+01:22:35,880 --> 01:22:40,240
+أليل frequency هذا على مستوى الـG لما أنا درست
+
+753
+01:22:40,240 --> 01:22:48,920
+الـ200 حالة اللي أنا قدرت أدرسهم فنتيجة الأمر هذا
+
+754
+01:22:48,920 --> 01:22:58,980
+راح يكون إنه مظهريًا كإنسان عنده مرض لهذه الحالة
+
+755
+01:22:58,980 --> 01:23:04,450
+زي في الـAfrican American هوواحد في الأربعمين اللي
+
+756
+01:23:04,450 --> 01:23:11,210
+هو بدك تحسبها وتشوف راح تطلع 0.0025 اللي هي واحد
+
+757
+01:23:11,210 --> 01:23:16,950
+في الأربعمين تضرب الـQ تربيه ناشط اللي هي الواحد
+
+758
+01:23:16,950 --> 01:23:22,330
+على الأربعمين شو نسبة الـCareers؟ واحد من عشرة
+
+759
+01:23:22,330 --> 01:23:29,350
+تقريبًا اللي هو راح تطلع 0.1 percent فالـ
+
+760
+01:23:30,120 --> 01:23:36,600
+الـ P و الـ Q نتكلم على نسبة القليل في دراسة أنت
+
+761
+01:23:36,600 --> 01:23:42,400
+تاخد كل أي إنسان عنده أثنين وأنا ما بعرف هو
+
+762
+01:23:42,400 --> 01:23:48,400
+الإنسان اللي أمامي هو Pure Capital A Capital A ولا
+
+763
+01:23:48,400 --> 01:23:52,600
+Capital A Small A ولا Small A Small A أنا لسه ما
+
+764
+01:23:52,600 --> 01:23:58,810
+بعرف بس كمجمل Capital A و Small A مجموعهمرح يكون
+
+765
+01:23:58,810 --> 01:24:04,190
+الـ Frequency 1 واضح؟ في أسماء برضه يعني بتسأل عن
+
+766
+01:24:04,190 --> 01:24:07,750
+قضية الـ Q تربيع مش عارف إيه بتسأل بتقول يعني كيف
+
+767
+01:24:07,750 --> 01:24:11,170
+كيف الـ Q تربيع كيف جاب النسبة تبعتها لإنها مش
+
+768
+01:24:11,170 --> 01:24:16,370
+جواب Q ضرب Q لأ ليش مش جواب؟ مش عارف أنا استغرب من
+
+769
+01:24:16,370 --> 01:24:21,650
+السؤال اللي أمامي لأ لأ انت حسبيها 1 على 400 رح
+
+770
+01:24:21,650 --> 01:24:30,850
+تطلع 0.0025 وضربيهاماشي راح تعطيكي شو اسمه الـ Q
+
+771
+01:24:30,850 --> 01:24:38,030
+تربيع ماشي الأرقام اللي قدامكم اشتغلوا عليها الـ 1
+
+772
+01:24:38,030 --> 01:24:43,610
+على 400 حوّلها لكسب يعني حوّلها لـ 0.0025 راح
+
+773
+01:24:43,610 --> 01:24:48,690
+تلاقي كيف تيجي ماشي رياضيا الأرقام مظبوطة اللي
+
+774
+01:24:48,690 --> 01:24:54,790
+قدامكم 100% يعني بس بدأ الواحد يفهم معنا شو الـ Q
+
+775
+01:24:54,790 --> 01:24:59,530
+شو الـ Pوليش الـ heterozygous يعني اللي هو الـ
+
+776
+01:24:59,530 --> 01:25:06,750
+career percentage بهذا الشكل، آه فلس تمام، أعتقد
+
+777
+01:25:06,750 --> 01:25:09,590
+الأمور واضحة بالنسبة للأشخاص اللي سألوا يعني هنا
+
+778
+01:25:09,590 --> 01:25:13,490
+ننتبه إنه لما نكون dominant إذا أنا عارف إنه
+
+779
+01:25:13,490 --> 01:25:18,750
+dominant ال incidence للـ disease هي الـ Q تربية
+
+780
+01:25:18,750 --> 01:25:25,720
+زي الـ 2PQ، هذه نسبة مجموعة أثنين، ماشي؟وإذا أنا
+
+781
+01:25:25,720 --> 01:25:31,900
+بقدر يعني تعطيني أي رقم لـ Incidence of an allele
+
+782
+01:25:31,900 --> 01:25:37,660
+أو mutation راح تلاقي، راح تكون هذه النسب صحيحة أو
+
+783
+01:25:37,660 --> 01:25:43,800
+مظبوطة يعني طيب، إذا خلصنا السؤال، الآن نيجي على
+
+784
+01:25:43,800 --> 01:25:52,390
+موضوع آخر استفادة من هذه الجانبيعني بالذات الأمر
+
+785
+01:25:52,390 --> 01:25:57,050
+في أمور الـ Genetics أحيانًا مربوط بالدول المتقدمة
+
+786
+01:25:57,050 --> 01:26:04,990
+حضارياً ومادياً وصحياً وطبياً بتلاقي يعني فيه
+
+787
+01:26:04,990 --> 01:26:09,330
+جوانب بتكلموا
+
+788
+01:26:09,330 --> 01:26:17,970
+عن يعني حقيقةً هي تقدم تقني في إمكانية عمل فكوصات
+
+789
+01:26:21,730 --> 01:26:28,770
+من أنواع الفحوصات هي طريقة يعني أنا كنت مرة ذكرت
+
+790
+01:26:28,770 --> 01:26:32,850
+معلومة من قبل فيه دراسات لما درسوا الـ
+
+791
+01:26:32,850 --> 01:26:38,930
+Mitochondrial Inheritance و Mitochondrial Diseases
+
+792
+01:26:38,930 --> 01:26:44,990
+أو Mitochondrial DNAلقينا طبعاً الـ mitochondrial
+
+793
+01:26:44,990 --> 01:26:49,690
+DNA بنتقلش إلا عن طريق الأم الأب ما إجوا دخلوا ومن
+
+794
+01:26:49,690 --> 01:26:54,970
+مصدر واحد يعني فقط عن طريق الأم في البويضة بتمنقل
+
+795
+01:26:54,970 --> 01:26:58,530
+الـ mitochondrial chromosome و الـ mitochondrial
+
+796
+01:26:58,530 --> 01:27:09,340
+DNA فنتيجة لما تيجي أنت تدرس يكون عندك آلةتقدر
+
+797
+01:27:09,340 --> 01:27:17,400
+تعمل نوع من الـGenetic Testing سواء باستخدام يعني
+
+798
+01:27:17,400 --> 01:27:27,460
+طبعاً باستخدام الـVCR باستخدام الـ… باستخدام أنه
+
+799
+01:27:27,460 --> 01:27:32,040
+عن طريق Enzymes بتقصوا الـDNA في أماكن معينة
+
+800
+01:27:34,990 --> 01:27:46,530
+فبيسموها يعني أنواع من الـ يعني من الآلات ماشية
+
+801
+01:27:46,530 --> 01:27:50,030
+تقدر
+
+802
+01:27:50,500 --> 01:27:55,180
+يعني بالنسبة للـ Mitochondrial DNA في الأخير،
+
+803
+01:27:55,180 --> 01:28:00,940
+النتيج اللي وصلوها إنه قدروا يثبتوا أو يشوفوا إنه
+
+804
+01:28:00,940 --> 01:28:06,800
+في الأخير كل البشر بيرجعوا لـ7 أمهات إنه كل البشر
+
+805
+01:28:06,800 --> 01:28:12,700
+إنه سبع أنواع من الـMitochondrial DNA أو
+
+806
+01:28:12,700 --> 01:28:18,180
+Mitochondrial Chromosomes وهذه السبع أنواع محفوظين
+
+807
+01:28:18,180 --> 01:28:26,750
+فيها إحناوإنه بالأخير يعني بتدعوا إنه بنرجع
+
+808
+01:28:26,750 --> 01:28:33,210
+بالأخير لسبع إنات كانوا هم مصدر البشرية كلها
+
+809
+01:28:33,210 --> 01:28:36,750
+أحياناً
+
+810
+01:28:36,750 --> 01:28:43,730
+يعني كناحي وراثية بس أهم من هيك إنه الـ
+
+811
+01:28:47,150 --> 01:28:57,710
+إذا عندي أنا آليات، أجهزة، إمكانات في يعني في
+
+812
+01:28:57,710 --> 01:29:00,790
+الولايات المتحدة الأمريكية أو بريطانيا أو أوروبا
+
+813
+01:29:00,790 --> 01:29:09,010
+أحيانًا بيصير الواحد يقول أنا بدي أفهم أنا شوه
+
+814
+01:29:09,010 --> 01:29:15,530
+أصولي يعني في أمريكا للحظة معينة يعني في التاريخ
+
+815
+01:29:15,530 --> 01:29:24,620
+العجوديةكان عندهم إنه الأسود هو اللي نسبة السواد
+
+816
+01:29:24,620 --> 01:29:31,880
+فيه أكثر من واحد في ستاشر واحد من ستاشر يعني إذا
+
+817
+01:29:31,880 --> 01:29:41,720
+أبوه أسود أو أمه سودة فنسبة السواد فيه نص أو واحد
+
+818
+01:29:41,720 --> 01:29:49,670
+على اتنين إذا جدودهإذا الربع
+
+819
+01:29:49,670 --> 01:29:56,270
+يعني هم أربعة إذا واحد أسود بيظلوا بيعتبروا أسود
+
+820
+01:29:56,270 --> 01:30:03,410
+إذا واحد أبو جدوده واحد أسود مش مشكلة ما
+
+821
+01:30:03,410 --> 01:30:08,570
+بيعتبروهوش أسود طبعاً في الحالة هذه بيكون أقل من
+
+822
+01:30:08,570 --> 01:30:16,160
+واحد من تمانية ماشي؟فطلعت شغلة إنه إحنا من وين
+
+823
+01:30:16,160 --> 01:30:21,820
+جينا وشو نسبة ال .. يعني .. يعني ده الواحد بتطلع
+
+824
+01:30:21,820 --> 01:30:25,000
+على .. لما بيكونوا يتطلعوا على وجه الناس وكنا خلقة
+
+825
+01:30:25,000 --> 01:30:29,840
+ربنا وكنا كويسين بتلاقي مثلا في أمريكا السود اللي
+
+826
+01:30:29,840 --> 01:30:33,060
+من أمريكا .. في أمريكا نفسهم اللي انتهوا وجاي أسود
+
+827
+01:30:33,060 --> 01:30:38,060
+بتلاقي سواده شديد وشكله بشكل معين السود اللي في
+
+828
+01:30:38,060 --> 01:30:41,650
+أمريكا والله فيه نسبة كبيرة منهمبتقول عنه أنا عارف
+
+829
+01:30:41,650 --> 01:30:49,010
+هذا مخلط يعني أذا نائبة المرشح «بايدن» تبع أمريكا
+
+830
+01:30:49,010 --> 01:30:55,010
+بالانتخابات بتلاقيها يعني هي تقريبًا بيضة يعني مش
+
+831
+01:30:55,010 --> 01:31:02,110
+تودة كتير كتير كتير بس مش بيضة يعني على نفس الخطة
+
+832
+01:31:02,110 --> 01:31:08,530
+في الأدوات
+
+833
+01:31:09,240 --> 01:31:16,700
+في نفس الـ… يعني نسميها
+
+834
+01:31:16,700 --> 01:31:23,800
+أدوات أو فحوصات بتبين ليه لما إحنا نتكلم على وندور
+
+835
+01:31:23,800 --> 01:31:30,680
+على«ancestry informative markers» يعني على مؤشرات
+
+836
+01:31:30,680 --> 01:31:37,050
+معينةحاولوا من خلال دراسات من قبل جابوا أبيض أبيض
+
+837
+01:31:37,050 --> 01:31:42,650
+مظبوط وPure من كذا generation عرقيل وأسود Pure من
+
+838
+01:31:42,650 --> 01:31:47,870
+كذا generation وHispanic وأجوا درسوا الموضوع هذا
+
+839
+01:31:47,870 --> 01:31:52,510
+لقينا إنه مثلا في البيض
+
+840
+01:31:55,620 --> 01:32:00,080
+الغالبية العظمى من المؤشرات بتلاقيها باللون الأزرق
+
+841
+01:32:00,080 --> 01:32:06,640
+بهذا الشكل وعطوها لمعنى معين بالنسبة للـ African
+
+842
+01:32:06,640 --> 01:32:10,920
+Americans يعني الدولة بالسود بكونوا بهذا الشكل الـ
+
+843
+01:32:10,920 --> 01:32:15,460
+European Americans اللي من أصول أوروبية بتلاقيهم
+
+844
+01:32:15,460 --> 01:32:20,660
+بهذا الشكل ولمّا درسوا مجموعة ثالثة لقوها بهذا
+
+845
+01:32:20,660 --> 01:32:27,190
+الشكلفإذا واحد في أمريكا وعنده مثلًا ألف دولار
+
+846
+01:32:27,190 --> 01:32:33,830
+مقدر يدفعهم للمختبر بدرس هذه الـ Markers هدولة
+
+847
+01:32:33,830 --> 01:32:39,930
+وبطلعوله report أنت والله خمسين بالمية أبيض تلاتين
+
+848
+01:32:39,930 --> 01:32:49,140
+بالمية أسود عشرة بالمية مثلًايهودي مثلاً أو Middle
+
+849
+01:32:49,140 --> 01:32:56,520
+Eastern 10% صيني وبيعطوه نسب شو هو تركيبته الجينية
+
+850
+01:32:56,520 --> 01:33:03,120
+الوراطية من ناحية زي هيك يعني هذه يعني ما بعرف
+
+851
+01:33:03,120 --> 01:33:11,340
+طبياً مدى أهميتها أو يعني هي مؤشر كيف البشر كلنا
+
+852
+01:33:11,750 --> 01:33:17,950
+ولاد آدم وحوة وكلنا ممكن نتزوج من بعض وبنخلّط يعني
+
+853
+01:33:17,950 --> 01:33:24,770
+كلنا نفس النوع اللي هو الـ Species اللي بيكون يعني
+
+854
+01:33:24,770 --> 01:33:31,250
+من نفس المجموعة فالـ
+
+855
+01:33:31,250 --> 01:33:40,550
+يعني هنا مرات بدرست ترابط الأمور مع بعض والـ
+
+856
+01:33:41,260 --> 01:33:49,460
+يعني هاي طريقة برضه تانية لدراسة كيف مجمل يعني هنا
+
+857
+01:33:49,460 --> 01:33:55,620
+الفكرة عبارة عن هي دراسة للـ DNA بس الـ DNA الكلي
+
+858
+01:33:55,620 --> 01:34:01,260
+يعني ما احنا هنا بنتكلم على شخص على الـ Gen معين
+
+859
+01:34:01,260 --> 01:34:09,000
+بشكل محدد هنا هذه الدراسة بيستخدموا مثلا هنا 430
+
+860
+01:34:09,000 --> 01:34:18,730
+Markerباستخدام تقنية معينة بشكل معين بحيث إنه هيك
+
+861
+01:34:18,730 --> 01:34:23,410
+شكل الشخص اللي من أصول أفريقية هيك شكل الشخص اللي
+
+862
+01:34:23,410 --> 01:34:30,270
+من أصول أوروبية هيك من الإنسان المخلط وبإمكاني إني
+
+863
+01:34:30,270 --> 01:34:35,890
+من خلالها أطلع شو تأثير ال population هذهما هي
+
+864
+01:34:35,890 --> 01:34:40,770
+أصول البشر اللي فيها أصول أوروبية أو أصول أفريقية
+
+865
+01:34:40,770 --> 01:34:44,930
+أو أصول إسبانية أو أصول صينية أو أصول هندية أو
+
+866
+01:34:44,930 --> 01:34:54,310
+أصول أكتر أنواع مختلفة يعني هذه مجمل القضايا اللي
+
+867
+01:34:54,310 --> 01:35:01,910
+موجودة في محاولة وصف الـ Variation
+
+868
+01:35:03,260 --> 01:35:08,700
+للـGenetic Diseases أو الـGenetics in Population
+
+869
+01:35:08,700 --> 01:35:15,800
+يعني في مجمل population معينة أحنا هنا ما بنتكلم
+
+870
+01:35:15,800 --> 01:35:24,260
+عن شخص واحد كيف وضعه، إنما على إشعار، في أسئلة؟
+
+871
+01:35:24,260 --> 01:35:28,920
+في سؤال من كريمة، دكتور أتفضلي يا كريم، كويس، أه
+
+872
+01:35:30,430 --> 01:35:39,270
+كريم، تفضّل اسأل الدكتور سؤال مباشر إذا حابب هلجيت
+
+873
+01:35:39,270 --> 01:35:43,190
+أنت في الأول قُلت من أحد الافتراضات عشان يعمل هذه
+
+874
+01:35:43,190 --> 01:35:47,110
+الفرضية إنه يكونش في migration أحنا بنفترض إن
+
+875
+01:35:47,110 --> 01:35:51,150
+مافيش migration حصر، إيش جزء من ال migration هذا؟
+
+876
+01:35:51,150 --> 01:35:59,620
+ال migration هو حدد وفيه إله تأثير علىبسموه الـ
+
+877
+01:35:59,620 --> 01:36:04,460
+Founder Effect كويس، ذكرتني فيه كان لازم نحكي عنه
+
+878
+01:36:04,460 --> 01:36:15,300
+الآن لما أنت تيجي عشان تفهم الـ P و الـ Q و الـ QQ
+
+879
+01:36:15,300 --> 01:36:22,860
+و P هاي اللي حطيناها الإفتراضات الأولى مهمة جداً
+
+880
+01:36:22,860 --> 01:36:28,540
+إن الـ Population Study is largeوالـ Matings are
+
+881
+01:36:28,540 --> 01:36:34,580
+random شو يعني random؟ يعني مافيش مثال زي الـ Zero
+
+882
+01:36:34,580 --> 01:36:38,640
+Fitness هذا إنه إذا صار ميوتاشيا معينة ماحدش بتجوز
+
+883
+01:36:38,640 --> 01:36:44,420
+هذا الإنسان فهو يعني ممكن صفة معينة تتخلي هذا
+
+884
+01:36:44,420 --> 01:36:49,440
+الإنسان مش مرغوب ماحدش بده يتجوزها أو حدا يتجوز
+
+885
+01:36:49,440 --> 01:36:56,310
+المصاد هذا فكل هذه الاشتراطات حاجةبتعتمد على إن
+
+886
+01:36:56,310 --> 01:37:01,770
+الـ population كبيرة ومفتوحة طيب تيجي أنت مثلًا
+
+887
+01:37:01,770 --> 01:37:08,110
+على مجموعة موجودة ومستقرة في هذا المكان فجأة مثلًا
+
+888
+01:37:08,110 --> 01:37:12,990
+إحنا في شمال الأردن أو في الأردن يجينا migration
+
+889
+01:37:12,990 --> 01:37:21,030
+مثلًا الله يفق عنهم السوريين ماشي وإحنا مثلًا
+
+890
+01:37:21,030 --> 01:37:27,390
+الأصل إحنا مثلًا مثلًا مليونيجينا ربع مليون سوري
+
+891
+01:37:27,390 --> 01:37:33,670
+فجأة مرة واحدة وأنا أدرس احتمالية الجينات حدوث
+
+892
+01:37:33,670 --> 01:37:40,110
+الهجرة هذه ممكن تغير لنسب الجينات بحيث إن الأرقام
+
+893
+01:37:40,110 --> 01:37:45,770
+اللي عندي قد لا تكون سليمة وأحياناً هذا موضوع مؤثر
+
+894
+01:37:45,770 --> 01:37:50,150
+يعني الـ… الـ population بالذات إذا بيصير فيها
+
+895
+01:37:50,150 --> 01:37:56,830
+isolation يعني مثلاً في أمريكاإذا بتسمع مجموعة
+
+896
+01:37:56,830 --> 01:38:00,490
+اللي بيسموهم الـ Amish أو الـ «مارموند» أو الـ
+
+897
+01:38:00,490 --> 01:38:07,510
+يعني هدولة مجموعات هدولة مثلا في أمريكا صحيح بس
+
+898
+01:38:07,510 --> 01:38:14,130
+هدولة من أصول يعني زي يعني بضربها مثل إذا بتروح
+
+899
+01:38:14,130 --> 01:38:20,350
+على سوريا ولا بلبنان بتلاقي المخيمات للفلسطينيين
+
+900
+01:38:20,350 --> 01:38:27,640
+بقولك المنطقة الفلانيةاللي انتهجروا من صفر المنطقة
+
+901
+01:38:27,640 --> 01:38:31,040
+الأفلانية اللي انتهجروا من الناصرة المنطقة
+
+902
+01:38:31,040 --> 01:38:35,980
+الأفلانية اللي انتهجروا من يعني حتى مثلا لغزة فلما
+
+903
+01:38:35,980 --> 01:38:41,180
+انتقلت نوع من الـ Migration بيغير يعني ممكن إذا
+
+904
+01:38:41,180 --> 01:38:46,120
+صار تزاوج بس في منطقة معينة يعني هدولة اللي بحكي
+
+905
+01:38:46,120 --> 01:38:51,160
+عنهم الـ Mormons أو القامش في أمريكا إذا تدخل على
+
+906
+01:38:51,160 --> 01:38:57,510
+هيك تشوف صورهم بتميزوه يعنيعبارة عن يعني ناس من
+
+907
+01:38:57,510 --> 01:39:03,810
+ألمانيا شبيهين جدا للألمان كشكل وللأن كثقافة
+
+908
+01:39:03,810 --> 01:39:10,710
+وبتزوجوش إلا من بعض وبخلفوا كثير فبتلاقي أنت هنا
+
+909
+01:39:10,710 --> 01:39:14,750
+الـ population هذه أحياناً بعض الـ diseases
+
+910
+01:39:14,750 --> 01:39:19,810
+بتلاقيها نسبتها أعلى بكتير بسبب اللي بيسمونه
+
+911
+01:39:19,810 --> 01:39:24,700
+Founder Effect يعنيإنه اللي بدأ هذه الـ Population
+
+912
+01:39:24,700 --> 01:39:31,420
+يعني مثلًا تتوقع مثلًا الجزيرة سفينة اتحطمت على
+
+913
+01:39:31,420 --> 01:39:38,180
+الجزيرة هذه فيها مثلًا عشرين زلمة ومرة تيجي بعد
+
+914
+01:39:38,180 --> 01:39:42,920
+200 سنة والجزيرة هذه معزولة، شو اللي راح يصير؟
+
+915
+01:39:42,920 --> 01:39:48,840
+بسبب إنه بدأت هذه من مجموعة قليلة وما صارش عليهم
+
+916
+01:39:48,840 --> 01:39:54,730
+هجرةوماتغيرتش، فبتلاقي النسب مختلفة عن غيرها، هذا
+
+917
+01:39:54,730 --> 01:40:02,270
+المقصود وقضية الهجرة من ناحية مؤثرة على نسب الـ P
+
+918
+01:40:02,270 --> 01:40:12,130
+و الـ Q راح تتأثر شو موجودة لأنه هنا … يعني
+
+919
+01:40:12,130 --> 01:40:19,450
+هنا صار حدث معين بطريقة معينة اللي هو أنه بداية ال
+
+920
+01:40:19,450 --> 01:40:25,910
+population هذهكانت عندهم Gen معين، شكل معين، نسبته
+
+921
+01:40:25,910 --> 01:40:31,270
+أكتر واحد، اثنين أو غيرهم مصابين فبالتالي ضالوا
+
+922
+01:40:31,270 --> 01:40:35,750
+ظاهر وبالتالي يعني الـ… الـ… الـFrequency تبعته
+
+923
+01:40:35,750 --> 01:40:39,730
+أعلى بكتير المعادلات اللي بنحكيها على هذه
+
+924
+01:40:39,730 --> 01:40:44,510
+الافتراضات اللي هي أنه الـP و الـQ لما نعتبرها
+
+925
+01:40:44,510 --> 01:40:50,020
+بهذا بس يعني مثلا لما تتكلم نقص أمريكاهي عندي
+
+926
+01:40:50,020 --> 01:40:56,540
+الـWhites أو الـEuropeans أو الـCaucasians وفيه
+
+927
+01:40:56,540 --> 01:41:00,220
+الـBlacks وفيه الـHispanics ودرجة الاختلاف هذه
+
+928
+01:41:00,220 --> 01:41:06,780
+طبعاً راح تتأثر إذا في تزاوج أو مافيش تزاوج وكم
+
+929
+01:41:06,780 --> 01:41:13,180
+نسبة اللي بتزاوجوا من بين الـRaces اللي هي يعني
+
+930
+01:41:13,180 --> 01:41:20,230
+العراق البشريةماشي الصينيين الأفارقة الأوروبيين
+
+931
+01:41:20,230 --> 01:41:24,570
+القوقازيين يعني بدك تاخدها بعين الاعتبار في سؤال
+
+932
+01:41:24,570 --> 01:41:31,270
+واضحط ان شاء الله القضية الله يعفوكم ونشوفكم يوم
+
+933
+01:41:31,270 --> 01:41:34,970
+الأربع ان شاء الله واجهزوا للامتحان الله يعفوكم
+
+934
+01:41:34,970 --> 01:41:37,990
+الله
+
+935
+01:41:37,990 --> 01:41:41,470
+يعفوكم يا دكتور الله يعفوكم أهلا و أهلا و السلام
+
+936
+01:41:41,470 --> 01:41:41,790
+عليكم
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/vL1zB0LyhmE_raw.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/vL1zB0LyhmE_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..e6395d09aeb5bc70b5901d700c80a62d8544b13c
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/vL1zB0LyhmE_raw.srt
@@ -0,0 +1,3749 @@
+1
+00:00:00,000 --> 00:00:05,780
+في عرض السؤال يُذكر
+
+2
+00:00:05,780 --> 00:00:11,960
+إنه مش فاهم الصورة هذه نعود
+
+3
+00:00:11,960 --> 00:00:17,360
+مرة ثانية بالكاميرا دكتور إذا في ممكنية بستعمل
+
+4
+00:00:17,360 --> 00:00:26,360
+مشاركة للشاشة برضه؟ آه، آه، طيب خلّيني بس أتأكد،
+
+5
+00:00:26,360 --> 00:00:28,200
+سأعمل
+
+6
+00:00:33,660 --> 00:00:50,060
+خلّيني أيضًا أتأكد من بعث هذا الفيديو ‏-719،
+
+7
+00:00:50,060 --> 00:00:56,180
+ليس الصورة هذه ‏-
+
+8
+00:01:06,510 --> 00:01:13,290
+ماشي، حسّا، شو اللي بنقدر نقوله عن القصة بالنسبة
+
+9
+00:01:13,290 --> 00:01:21,890
+لسؤال زميلكم؟ بيسألني،
+
+10
+00:01:21,890 --> 00:01:25,150
+ممكن لو سمحت ما عرفت الـGenotype لكل من الزوج
+
+11
+00:01:25,150 --> 00:01:30,150
+والزوجة في هذه الحالة بالنسبة
+
+12
+00:01:30,150 --> 00:01:39,790
+للسؤال هذايعني الأهم إن الواحد يكون
+
+13
+00:01:39,790 --> 00:01:43,950
+قادر يقرأ الـ Pedigree هذه أو الشجرة العالية هذه
+
+14
+00:01:43,950 --> 00:01:48,650
+بطريقة سليمة يعني زوج وزوجي، أنا زوج وزوجي، يعني
+
+15
+00:01:48,650 --> 00:01:59,250
+فيه بالـ اللي هم الجيل الأول الأب
+
+16
+00:01:59,250 --> 00:02:04,290
+والأم اللي هم أبوا الـ يعنيأبو الجدود اللي هم اللي
+
+17
+00:02:04,290 --> 00:02:09,350
+فوق زي ما انت حطيت هنا لما نحط أزرق معناماته مصاب
+
+18
+00:02:09,350 --> 00:02:15,150
+لما نعبيها جوا لما نحط عليها شرطة معناته متوفة
+
+19
+00:02:15,150 --> 00:02:23,830
+فأبو الجد وأم
+
+20
+00:02:23,830 --> 00:02:29,760
+الجد أو الجدود اثنين هم متوفيناللي فيه حطيه نقطة
+
+21
+00:02:29,760 --> 00:02:34,720
+بالنص، هذه معناته «حامل» «Carrier» اللي عليه إشارة
+
+22
+00:02:34,720 --> 00:02:44,880
+كذا «مشطوب»، يعني متوفة فهنا بتتكلم عن عائلة من
+
+23
+00:02:44,880 --> 00:02:48,260
+Extended
+
+24
+00:02:48,260 --> 00:02:55,080
+Familyالجيل الرابع عندهم تمنتاشر شخص مرقمينهم واحد
+
+25
+00:02:55,080 --> 00:03:00,020
+لحد تمنتاشر واضح الجيل الثالث عشر أشخاص الجيل
+
+26
+00:03:00,020 --> 00:03:07,700
+الثاني أربع أشخاص الجيل الثاني فيه ذكور وفيه إناف
+
+27
+00:03:07,700 --> 00:03:11,160
+أثنينهم
+
+28
+00:03:11,160 --> 00:03:16,300
+مصابين أثنينهم آسف الجيل الثاني فيه ذكور وفيه إناف
+
+29
+00:03:16,300 --> 00:03:23,270
+أثنينهمحاملين للمرض Carriers لأنه صحيح أحنا بنعرف
+
+30
+00:03:23,270 --> 00:03:29,450
+أن الأم الجد أو الجيل الأول الأنثى كانت مصابة بس
+
+31
+00:03:29,450 --> 00:03:37,490
+الإصابات بالنسبة لـ .. بالنسبة من الأحفاد وأبناء
+
+32
+00:03:37,490 --> 00:03:42,250
+الأحفاد فيه بالذكور وفيه بالإناف يعني هذه الثنتين
+
+33
+00:03:45,430 --> 00:03:51,930
+اللي هي يعني فيها
+
+34
+00:03:51,930 --> 00:03:57,630
+أكثر من شخص مصادر فلما يكون أبيض تمامًا معناته
+
+35
+00:03:57,630 --> 00:04:05,130
+سليم الـ Genotype الـ Genotype النُص معناته Career
+
+36
+00:04:05,130 --> 00:04:14,250
+والـ Fullمظلّل بالكامل، هذا معناته إنسان مصاب فهيك
+
+37
+00:04:14,250 --> 00:04:20,530
+الواحد بدي يقراهم، ماشي؟ فأنا مافهمتش الزوج
+
+38
+00:04:20,530 --> 00:04:24,930
+والزوجة هنا شو الـ Genotype الـ Genotype، هاي مصاب
+
+39
+00:04:24,930 --> 00:04:32,710
+وهاي بدي يكون Free لما نقول Career، معناته هذه
+
+40
+00:04:32,710 --> 00:04:35,350
+الصفة متنحية، ماشي؟
+
+41
+00:04:38,620 --> 00:04:44,520
+ممكن تكون متنحي، ممكن تكون .. إذا في .. يعني هنا
+
+42
+00:04:44,520 --> 00:04:47,200
+بتتكلموا على إن أحيانًا
+
+43
+00:04:49,880 --> 00:04:56,960
+أحنا بنتكلم عن صفة يعني إحنا اللي بنحب هيك نفهمها
+
+44
+00:04:56,960 --> 00:05:02,480
+بسهولة وأبسط شيء فيه سائد وفيه متنحي إن السائد هو
+
+45
+00:05:02,480 --> 00:05:07,360
+اللي بيظهر والمتنحي بيختفي إلا إذا كان two copies
+
+46
+00:05:07,360 --> 00:05:13,140
+هذا الكلام مش دائما 100% بهذه الطريقة هذا الكلام
+
+47
+00:05:13,140 --> 00:05:24,740
+أحياناً مش كاملمن ناحية إن أحيانًا الصفة
+
+48
+00:05:24,740 --> 00:05:30,300
+الوراثية ما بتبين في مجموعة معينة أو في ناس معينين
+
+49
+00:05:30,300 --> 00:05:37,360
+بشكل قوي فبتلاقيها مش ظاهرة يعني فهي النقطة اللي
+
+50
+00:05:37,360 --> 00:05:43,060
+يحب واحد منكم يسألها والمقصود في الموضوع إنه يتعود
+
+51
+00:05:43,060 --> 00:05:50,300
+الواحد يقرأ عن الصفة الوراثيةكيف يقرأ الـ Pedigree
+
+52
+00:05:50,300 --> 00:05:55,520
+«Choose Simple» معناتها هنا في ذكور وفي إناث
+
+53
+00:05:55,520 --> 00:06:01,440
+مصابين وفي كل الأجيال بشكل واضح وإن كان الجيل
+
+54
+00:06:01,440 --> 00:06:07,920
+الثاني هنا مافيش مصابين، فيه Carriers اللي متوفر
+
+55
+00:06:07,920 --> 00:06:12,820
+رقم ثلاثة أنثى مابنعرفش كانت مصابة ولا غير مصابة
+
+56
+00:06:12,820 --> 00:06:26,090
+واضح إنه الصابد يعنيفي تفاوت فيها يعني هو
+
+57
+00:06:26,090 --> 00:06:32,530
+أنا لما اتكملوا بالنسبة للـ Pedigree ماحطوش كل
+
+58
+00:06:32,530 --> 00:06:37,490
+المعلومات الأخرى يعني أخدوا عيلة واحدة فقط من جانب
+
+59
+00:06:37,490 --> 00:06:42,730
+واحد يعني الشاب
+
+60
+00:06:42,730 --> 00:06:49,430
+هذا أو الزلمي هذا حتى جابالثلاث أفراد هدولة لازم
+
+61
+00:06:49,430 --> 00:06:53,590
+تتزوج بواحدة فهذه أيضًا ليست محطوطة يعني فهنا فيه
+
+62
+00:06:53,590 --> 00:07:00,630
+معلومات مش كاملة بس على الأقل يعني الواحد يعني هنا
+
+63
+00:07:00,630 --> 00:07:06,590
+career أو مش واضح يعني هيك بنعتبرها وفيه إنه
+
+64
+00:07:06,590 --> 00:07:10,640
+مصابين وفيه إنه غير مصابينأتأمل إن إن شاء الله
+
+65
+00:07:10,640 --> 00:07:19,320
+تكون الصورة هيوضحك بالنسبة لسؤال الفائل لأنه كانت
+
+66
+00:07:19,320 --> 00:07:27,500
+الأمور واضحة في أسئلة؟ في أسئلة أخرى عن اللي
+
+67
+00:07:27,500 --> 00:07:31,980
+اتناولناها المرة اللي فاتت؟
+
+68
+00:07:31,980 --> 00:07:36,780
+طيب
+
+69
+00:07:37,630 --> 00:07:46,370
+بالنسبة لليوم، بدنا نحاول نفهم لما نتكلم عن
+
+70
+00:07:46,370 --> 00:07:55,550
+الوراثة والـ Genetics في population بالنسبة للجنس
+
+71
+00:07:55,550 --> 00:08:03,370
+البشري كله بكلام عام، شو الأسس وكيف نتكلم وكيف
+
+72
+00:08:03,370 --> 00:08:10,930
+نتعامل مع موضوع زي هذهفي مفهوم حتى نعرف إيه يكون
+
+73
+00:08:10,930 --> 00:08:21,870
+عندنا مرتكز نبدأ منه في قضية فهم يعني كيفية
+
+74
+00:08:21,870 --> 00:08:29,230
+التعامل مع الوراثة في مفهوم يسمونه
+
+75
+00:08:29,230 --> 00:08:33,650
+قانون Hardy-Weinberg القانون هذا قانون الوراثة
+
+76
+00:08:33,650 --> 00:08:44,570
+بسميه قانون الوراثةإنه بالنسبة له عند وجود جين
+
+77
+00:08:44,570 --> 00:08:54,330
+أصلي ومتغير قليل له أو شكل آخر منه لما نكون هذول
+
+78
+00:08:54,330 --> 00:09:01,290
+أثنين موجودين في البشرية، في الـPopulation كلها
+
+79
+00:09:01,290 --> 00:09:10,520
+القانون هذاراح ناخده بعد شوية كيف بتعامل مع نسب
+
+80
+00:09:10,520 --> 00:09:19,740
+تواجد كل قليل بفترض هذا القانون أدت افتراضات بدي
+
+81
+00:09:19,740 --> 00:09:26,620
+الواحد يكون متنبه إلها عشان لما يتعامل يعني يكون
+
+82
+00:09:26,620 --> 00:09:32,600
+متنبه الواحد منها لاختلاف هذه الفرضية عن الواقع
+
+83
+00:09:32,600 --> 00:09:42,400
+أحيانًاالـ الـ الـ الـ population أو المجموعة اللي
+
+84
+00:09:42,400 --> 00:09:48,940
+احنا الكلية اللي عم ندرسها الأصل حتى نطبق هذا
+
+85
+00:09:48,940 --> 00:09:53,520
+القانون ونعرف نشتغل بالمعادلة تبعته ونسوي الأشياء
+
+86
+00:09:53,520 --> 00:10:00,060
+اللي فيه لازم تكون population كبيرة والتزاوج بين
+
+87
+00:10:00,060 --> 00:10:09,210
+أفراده كلهممسموح وبحدث ويعني مش مثلًا population
+
+88
+00:10:09,210 --> 00:10:15,310
+فيها two sub-populations يعني مثلًا في أمريكا
+
+89
+00:10:15,310 --> 00:10:20,350
+مثلًا نفترض البيض بيجوزوش السود والسود بيجوزوش
+
+90
+00:10:20,350 --> 00:10:26,010
+البيض ففي أمريكا مثلًا مجتمع نصف ثلاث، عشرين،
+
+91
+00:10:26,010 --> 00:10:32,830
+تلتاش، خمستاش بالمية سود وخمس وثمانينتقريبًا
+
+92
+00:10:32,830 --> 00:10:39,090
+بالمية بيرد ومافيش تزاوج بينهم إذا كان الأمر بهذه
+
+93
+00:10:39,090 --> 00:10:42,690
+الطريقة راح يخربط الدنيا ومش راح تكون القانون اللي
+
+94
+00:10:42,690 --> 00:10:49,350
+نحكي عنه منطبق فهو لـ Population كبيرة بتكون
+
+95
+00:10:49,350 --> 00:10:55,330
+إمكانية التزاوج بين أفراده مسموحة ومافيش أي
+
+96
+00:10:55,330 --> 00:11:03,110
+محددات، ماشي؟ فهذه ناحية مهمة ومبدألما نطبق
+
+97
+00:11:03,110 --> 00:11:13,870
+القانون الشيء الثاني أنه لما ندرسنا احتمالية أو
+
+98
+00:11:13,870 --> 00:11:18,810
+نسبة حدوث المتغير
+
+99
+00:11:18,810 --> 00:11:26,730
+من نوع ما للجين المتغير A أو B مثلاً سنجد أن
+
+100
+00:11:26,730 --> 00:11:32,790
+الافتراض الثاني في القانونإن النسب ثابتة يعني
+
+101
+00:11:32,790 --> 00:11:38,710
+مثلًا في population في نسبة القليل الأول تسعين
+
+102
+00:11:38,710 --> 00:11:42,570
+بالمية القليل الثاني عشرة بالمية من الناس عندهم هي
+
+103
+00:11:42,570 --> 00:11:49,580
+هكذا فمن يكون عشر أو تسعين هذه النسبة ثابتةمن إنها
+
+104
+00:11:49,580 --> 00:11:58,000
+ما بتتغيرش بسبب حدوث طفرات جديدة بتكون إنه تزاوج
+
+105
+00:11:58,000 --> 00:12:04,620
+مسموح ومافيش اختيار للنوع باتجاه نوع معين ومافيش
+
+106
+00:12:04,620 --> 00:12:10,220
+أي نوع من إدخال أو إخراج نسبة من الناس من خلال
+
+107
+00:12:10,220 --> 00:12:18,340
+الهجرات فالـ Immigrationيعني المطلوب إنه حتى نطبق
+
+108
+00:12:18,340 --> 00:12:23,840
+القانون اللي راح نحكي عنه راح يكون من خلال بيسموها
+
+109
+00:12:23,840 --> 00:12:29,700
+الـ Steady State حالة الاتزام، حالة الثبات فهذه
+
+110
+00:12:29,700 --> 00:12:38,740
+محددات أساسية في الرؤية لما نيجي نتكلم عنيعني
+
+111
+00:12:38,740 --> 00:12:44,300
+النسب والكافة الـ Diversity في المجتمع أو في الـ
+
+112
+00:12:44,300 --> 00:12:49,280
+Population بدنا ناخدها بعالي اعتبار إذا أخذنا هذه
+
+113
+00:12:49,280 --> 00:12:58,060
+النقاط بيعني بعالي اعتبار لما نيجي نتكلم عن يعني
+
+114
+00:12:58,060 --> 00:13:08,100
+كيف ننصف تفاوت البشر بالنسبة لصفة معينة ورافيةفهنا
+
+115
+00:13:08,100 --> 00:13:17,840
+أعطيكم مثال على موليكول أو على جزية أو على يعني
+
+116
+00:13:17,840 --> 00:13:24,640
+بروتين اللي يسموه CCR5 الـChemokines هذولة عبارة
+
+117
+00:13:24,640 --> 00:13:30,840
+عن مجموعة هرمونات بتتحكم في المناعة بتحدد وين
+
+118
+00:13:30,840 --> 00:13:40,030
+الخلايا بتروح فالـ Chemokines عددهم كبير ويعني
+
+119
+00:13:40,030 --> 00:13:43,910
+حوالي ما لا يقل عن مية يمكن الأنصار أو أكثر
+
+120
+00:13:43,910 --> 00:13:48,330
+اكتشفوا كلها عشان تتخلى خلايا المناعة تعرف أين
+
+121
+00:13:48,330 --> 00:13:55,490
+تروح فالـ Chemokines الأثبت والأهم هم الـReceptors
+
+122
+00:13:55,490 --> 00:14:02,350
+تبعتهم هم المستقبلات تبعتهم فعددهم بيسموه حسبالـ
+
+123
+00:14:02,350 --> 00:14:09,430
+Cytosine اللي هو Amino Acid Cytosine
+
+124
+00:14:09,430 --> 00:14:13,110
+Amino
+
+125
+00:14:13,110 --> 00:14:20,560
+Acid Particle أو Amino Acid بالـ Volume بتاعيفبيجي
+
+126
+00:14:20,560 --> 00:14:25,160
+ثنتين ورا بعض، فبيسموهم CC أنه ثنتين ورا بعض، مش
+
+127
+00:14:25,160 --> 00:14:33,940
+CXC أو CXXC يعني أنه فيه Amino Acid بينهم فالمهم،
+
+128
+00:14:33,940 --> 00:14:41,800
+الـChemokine رقم خمسة أشي مهم كمستقبل للـHIV
+
+129
+00:14:41,800 --> 00:14:49,410
+الـHIV إذا تتذكروا، بيستخدم الـCD4الـ GP120 على
+
+130
+00:14:49,410 --> 00:14:56,090
+الـ surface تبع الـ البروتين تبع الـ HIV الفيروس
+
+131
+00:14:56,090 --> 00:15:01,590
+الـ Human Immune Deficiency Virus فالـ الـ HIV
+
+132
+00:15:01,590 --> 00:15:07,510
+بيستخدم الـ CD4 موليكيون اللي على سطح الـ T-cells
+
+133
+00:15:07,510 --> 00:15:13,210
+والـ CCR5 على سطح الـ T-cells المستقبل الثاني إليه
+
+134
+00:15:13,210 --> 00:15:23,580
+فكانت ملاحظة من فترة أو كان عليها ضج كبير إنه في
+
+135
+00:15:23,580 --> 00:15:31,900
+بعض الـVariation في قابلية الخلايا إنها يتم غزوها
+
+136
+00:15:31,900 --> 00:15:40,320
+من خلال الـHIV من خلال Variations في الـCCR5ففي
+
+137
+00:15:40,320 --> 00:15:46,440
+نوع اكتشفناه بعدين بعض الناس عندهم «Delta CCR5»
+
+138
+00:15:46,440 --> 00:15:53,120
+«Deletion Elite» يعني بيصير عندهم إنه الـ «CCR5»
+
+139
+00:15:53,120 --> 00:15:57,940
+غير موجود بشكل طبيعي، عبارة عن بروتين مقطوع،
+
+140
+00:15:57,940 --> 00:16:06,740
+بروتينمش اسمه بروتيم مقطوع وبكون فيه stop codon
+
+141
+00:16:06,740 --> 00:16:14,300
+وبكون miss shift يعني الـ deletion خلّت إن قراءة
+
+142
+00:16:14,300 --> 00:16:20,100
+الـ DNA مش مظبوطة وبالتالي مافيش إنها الـ CCR5
+
+143
+00:16:20,100 --> 00:16:26,020
+القليل اللي هو مش طبيعي بكون فيه مشكلة فيه
+
+144
+00:16:30,070 --> 00:16:35,070
+رح نتفرج بعد شوية على كيف أنه بالنسبة كـ
+
+145
+00:16:35,070 --> 00:16:39,490
+population لهذا الجين
+
+146
+00:16:39,490 --> 00:16:48,310
+بالذات تم دراسته ونشوف كيف النتائج راح تكونفكان
+
+147
+00:16:48,310 --> 00:16:53,030
+فيه اهتمام بهذا الموضوع لأنه كان يفسر مقاومة البعض
+
+148
+00:16:53,030 --> 00:16:58,110
+للـ HIV قدرتهم على أنه يتعرضوا إليه بس ما ينصابوا
+
+149
+00:16:58,110 --> 00:17:07,330
+فكان مثير للاهتمام لما أجوا ودرسوا المعادلات
+
+150
+00:17:07,330 --> 00:17:12,610
+أو درسوا الوضع اللي موجود بالنسبة للـ
+
+151
+00:17:16,390 --> 00:17:23,370
+بين الـ CCR5 وبين الأليل اللي هو الـ Mutated اللي
+
+152
+00:17:23,370 --> 00:17:33,210
+هو فيه الـ Delusion اللي هو المقرب فدرسوا 788 شخص
+
+153
+00:17:33,210 --> 00:17:38,210
+الكلام بالـ 97 ماشي يعني يعني يعتبر دراسة قديمة
+
+154
+00:17:38,210 --> 00:17:46,880
+نوعاً ما درسوا حوالي 800 بني آدم ال .. ال ..البشر
+
+155
+00:17:46,880 --> 00:17:53,160
+اللي عندهم الـTwo copies normal ماشي حوالي 651
+
+156
+00:17:53,160 --> 00:17:59,160
+اللي عندهم نسخة واحدة من الـDeletion أو
+
+157
+00:17:59,160 --> 00:18:06,480
+الـAbnormal قليل مش الـWild type 134 واللي عندهم
+
+158
+00:18:06,480 --> 00:18:13,040
+Double the thing اللي هو الـMutations بالسنتين
+
+159
+00:18:13,040 --> 00:18:25,060
+سبعةفلما نحملها نسب راح نلاقي إن الـ one كاملة هي
+
+160
+00:18:25,060 --> 00:18:35,960
+الـ total للكل 82% عندهم الـ wild type 17% تقريبًا
+
+161
+00:18:35,960 --> 00:18:43,840
+عندهم one mutation واحد بالميةعندهم اللي هو الـ
+
+162
+00:18:43,840 --> 00:18:51,100
+Double Mutations وهي الأليل وهي اسمها Derived
+
+163
+00:18:51,100 --> 00:18:59,250
+Frequencies الأليل الفكرة من هناإنه لما نيجي ناخد،
+
+164
+00:18:59,250 --> 00:19:04,490
+طبعاً هنا عرفنا عنه إنه بس فيه عنا ثمان ماعناش عدد
+
+165
+00:19:04,490 --> 00:19:08,210
+أكبر من الـ Alleles يعني مثلا لما نيجي نقول إنه
+
+166
+00:19:08,210 --> 00:19:12,370
+نطبق القاعدة هذه وبهذه الطريقة تماماً على الـ ABO
+
+167
+00:19:12,370 --> 00:19:17,250
+System تبع الـ Blood Group الـ ABO System، لأ، فيه
+
+168
+00:19:17,250 --> 00:19:20,770
+ثلاث Alleles فما بيمشي عليه هذا القانون ما بتمشي
+
+169
+00:19:20,770 --> 00:19:24,650
+عليه هذه الطريقةإنما لما يكون عندى بس Two copies
+
+170
+00:19:24,650 --> 00:19:30,810
+يعني مثلًا الـ Rh Positive و Negative تبع الـ
+
+171
+00:19:30,810 --> 00:19:35,990
+Resource Factor أو الـ Blood Group الـ Rh ففي حالة
+
+172
+00:19:35,990 --> 00:19:40,390
+مثلًا الـ Rh ممكن أنا أطلع أرقام زي هيكة وأقول إن
+
+173
+00:19:40,390 --> 00:19:46,890
+البشر مثلًا كذا بالمية عندهم هيك وكذا بالمية عندهم
+
+174
+00:19:46,890 --> 00:19:47,450
+هيك
+
+175
+00:19:52,290 --> 00:19:59,250
+الملاحظة إذا افترضنا إنه الـ Frequency تبعت الـ
+
+176
+00:19:59,250 --> 00:20:04,370
+Normal أو الـ Baseline أو الـ Wild-type هنا سموه
+
+177
+00:20:04,370 --> 00:20:10,750
+الـ Wild-type يعني اللي مافيش فيه طفرة قليل النسبة
+
+178
+00:20:10,750 --> 00:20:19,870
+هنا تقريباً 91%اللي حصلناها وهنا تسعة بالمية الـ
+
+179
+00:20:19,870 --> 00:20:23,050
+«while» اللي هو تبعتر الـ «frequency» للـ
+
+180
+00:20:23,050 --> 00:20:28,490
+«mutation» للـ «abnormal» أو الـ «deleted» أو الـ
+
+181
+00:20:28,490 --> 00:20:35,650
+«abnormal» أو الـ «muted» فقط بذكر قاعدة مهمة إنه
+
+182
+00:20:35,650 --> 00:20:41,900
+تعدد الصور الـ «polymorphism» هذا لما نحكي عنهإذا
+
+183
+00:20:41,900 --> 00:20:46,240
+كان الـ mutation أكتر من 1% من الـ population فهو
+
+184
+00:20:46,240 --> 00:20:51,440
+نسبة عالية فهو نسبة كبيرة لما تكون 1% طبعا إذا 1%
+
+185
+00:20:51,440 --> 00:20:56,840
+مصاب بالـ gene هذا في نسبته بال population راح
+
+186
+00:20:56,840 --> 00:20:57,320
+يكون
+
+187
+00:21:00,140 --> 00:21:06,360
+تقريبًا راح يكون تقريبًا واحد بالعشر تلاف بين
+
+188
+00:21:06,360 --> 00:21:10,740
+الولادات عنده الإصابة هذه لأنه واحد بالمية في واحد
+
+189
+00:21:10,740 --> 00:21:15,640
+بالمية بيصير هيك النقطة يعني اللي بدنا نفهمها
+
+190
+00:21:15,640 --> 00:21:23,740
+وننتبه إليها بالنسبة لمثل هيك معادلة أنه شو
+
+191
+00:21:23,740 --> 00:21:29,290
+العلاقة بين هذول الرقمين وبين هالثلاث أرقامالرقم
+
+192
+00:21:29,290 --> 00:21:38,110
+الأول فوق هو يمثل 0.9%² إذا اعتبرنا إنه الـ
+
+193
+00:21:38,110 --> 00:21:44,630
+Frequency تبعت الـ CCR5 هي الـ P ماشي فرح تكون
+
+194
+00:21:44,630 --> 00:21:52,370
+اللي هي 0.9 فـ 0.9 تربيع رح تعطينا النسبة الأولى
+
+195
+00:21:52,370 --> 00:22:01,390
+اللي هي 81% أو 82%النفس الطريقة الأليل الـ deleted
+
+196
+00:22:01,390 --> 00:22:12,090
+اللي هو 9% لما نكون 9% أو almost 10% 10% يعني اللي
+
+197
+00:22:12,090 --> 00:22:23,630
+هو 10%×10% بيطلع 1% ماشي 0.1×0.1 بيطلع 0.01 فبتطلع
+
+198
+00:22:23,630 --> 00:22:30,630
+لك هيكوهذه تمثل «2PQ» الـ «P» اللي هي الـ
+
+199
+00:22:30,630 --> 00:22:34,310
+frequency تبع الأليل الأول والـ «Q» تبع الأليل
+
+200
+00:22:34,310 --> 00:22:39,950
+الثاني إذا بتضرب هدول اثنين الـ «2PQ» بتضرب هدول
+
+201
+00:22:39,950 --> 00:22:48,310
+الرقمين بعض يعني 90% في 10%، بتصير 9% 9% في 2،
+
+202
+00:22:48,310 --> 00:22:53,510
+تقريبًا 17% اللي شفناها هنا فالمعادلة اللي بيحكوا
+
+203
+00:22:53,510 --> 00:23:02,360
+عنهااللي هي يعني إنه نتذكر دايماً إنه P تربيع زائد
+
+204
+00:23:02,360 --> 00:23:08,060
+2PQ زائد Q تربيع بساوي واحد هيك يعني اللي بدنا
+
+205
+00:23:08,060 --> 00:23:15,760
+ناخدها اللي هي إنه مجموع هذولة القطعة الثلاثة اللي
+
+206
+00:23:15,760 --> 00:23:22,770
+هي الـMendelian inheritance الـSingle Geneالـ
+
+207
+00:23:22,770 --> 00:23:29,410
+Frequency للقليل الأول تربيع بالـ Homozygous زاد
+
+208
+00:23:29,410 --> 00:23:35,930
+الـ Frequency للقليل الثاني بالـ Homozygous وضعف
+
+209
+00:23:35,930 --> 00:23:41,690
+عدد الـ Heterozygous بتجمعهم كلهم بطلعة من واحد في
+
+210
+00:23:41,690 --> 00:23:50,350
+حالة الـ Equilibriumاللي هي لما يكون كل الصفات
+
+211
+00:23:50,350 --> 00:23:55,030
+اللي حكيناها population كبيرة مافيش فيها migration
+
+212
+00:23:55,030 --> 00:23:58,970
+مافيش limitation، عز وجل، بين مجموعة ومجموعة
+
+213
+00:23:58,970 --> 00:24:03,470
+والأمور مافيه mutation جديدة والأمور in a steady
+
+214
+00:24:03,470 --> 00:24:11,750
+state وكل الشروط هذه متحققة، الأمر بنتج عنه إن
+
+215
+00:24:11,750 --> 00:24:14,570
+مجموع القيم هذه لازم تساوي واحدة
+
+216
+00:24:18,210 --> 00:24:28,950
+فالآن لما نأخذ مثلًا نفترض إنه أنا بعرف الـ
+
+217
+00:24:28,950 --> 00:24:37,850
+Genotype هل هو Homozygous dominant أو Heterozygous
+
+218
+00:24:41,450 --> 00:24:48,150
+Homozygous, Recessive أو Heterozygous فلما أعرف
+
+219
+00:24:48,150 --> 00:24:57,390
+النسب ماشي بقدر أشوف كام بتصير احتمالية أنه يكون
+
+220
+00:24:57,390 --> 00:25:02,870
+نوعية معينة من الـ … إذا كان عندي الـ «mating» بـ
+
+221
+00:25:02,870 --> 00:25:06,450
+frequency بالأول وبتشوف شو الـ «offspring» راح
+
+222
+00:25:06,450 --> 00:25:17,850
+يطلعوبكون أنا في حالة يعني مثلًا «Aa»
+
+223
+00:25:17,850 --> 00:25:25,650
+مع «Aa» يعني إذا مثلًا إثنينهم هتروا زيكي مثلًا
+
+224
+00:25:25,650 --> 00:25:34,510
+«Aa» هاي راح يطلع عنها «4Q2B²Q²»
+
+225
+00:25:34,510 --> 00:25:35,530
+«4Q2B²Q²» «4Q2B²Q²» «4Q2B²Q²» «4Q2B²Q²» «4Q2B²Q²»
+
+226
+00:25:35,530 --> 00:25:36,950
+«4Q2B²Q²» «4Q2B²Q²» «4Q2B²Q²» «4Q2B²Q²» «4Q2B²Q²»
+
+227
+00:25:36,950 --> 00:25:36,990
+«4Q2B²Q²» «4Q2B²Q²» «4Q2B²Q²» «4Q2B²Q²» «4Q2B²Q²»
+
+228
+00:25:36,990 --> 00:25:43,320
+«4Q2B²Q²» «4Q2B²Q²» «هذولا إثنين هما يعني الـ
+
+229
+00:25:43,320 --> 00:25:49,300
+Offspring راح يكون الرُبع AA Capital الرُبع AA
+
+230
+00:25:49,300 --> 00:25:58,920
+Small أو Recessive والنُص راح يكونوا Heterozygous
+
+231
+00:25:58,920 --> 00:26:10,400
+فهي يعني مدخل لكيف إحنابنفكر لما نتكلم عن الـ
+
+232
+00:26:10,400 --> 00:26:19,160
+Frequencies تبعات الـ Certain Genotypes وكيف نسبهم
+
+233
+00:26:19,160 --> 00:26:24,320
+ووجودهم في المجتمعات، في الـ Populationوش هو همية
+
+234
+00:26:24,320 --> 00:26:27,920
+دراسة هذا الموضوع؟ إذا في حد عنده سؤال، يعني
+
+235
+00:26:27,920 --> 00:26:39,060
+أنا…………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………
+
+236
+00:26:48,740 --> 00:26:57,620
+قليل لما تدرس نسبته تسميها الـP الـMutated أو
+
+237
+00:26:57,620 --> 00:27:00,660
+الجين
+
+238
+00:27:00,660 --> 00:27:06,340
+الثاني اللي خربان أو فيه مرض أو فيه مشكلة تسميه
+
+239
+00:27:06,340 --> 00:27:15,170
+الـQ فإذا هنا لدراسة صفة معينة عندك Two Genesزي ما
+
+240
+00:27:15,170 --> 00:27:21,790
+حكينا عن مثال الـ «Gene» تبع الـ «CCR5» إبارة عن
+
+241
+00:27:21,790 --> 00:27:30,550
+إحنا اهتمنا في دراسته لأنه يمثل إحتمالية
+
+242
+00:27:30,550 --> 00:27:35,250
+الإصابة بالـ «HIV» والـ «Susceptibility» تبعته
+
+243
+00:27:35,250 --> 00:27:37,650
+يعني، لماذا بعض الناس بنصاب ولماذا بعض الناس
+
+244
+00:27:37,650 --> 00:27:42,350
+بنصبوه؟ فدرست هذا الـ «Gene» فانتبهت إنه عندي
+
+245
+00:27:42,350 --> 00:27:48,170
+إثنين منهمفالـ Wild-type العادي الأصلي بسمّي الـ
+
+246
+00:27:48,170 --> 00:27:53,050
+Frequency تبعته نسبة حدوثه في الاحتمالات بأعطيها
+
+247
+00:27:53,050 --> 00:28:01,290
+الرقم P و الـ Q هي نسبة الطفرة اللي هي قداش نسبة
+
+248
+00:28:01,290 --> 00:28:08,350
+حدوثها على أساس أنه زي ما رسمناه هنا بالمثال هذا
+
+249
+00:28:08,350 --> 00:28:15,440
+الـ P هي الـ Frequency تبعت الـ CCR5بنعطيها الـ «0
+
+250
+00:28:15,440 --> 00:28:22,200
+.9» وهذه بأعطيها «P» والـ «Delta» «CCR5» الـ
+
+251
+00:28:22,200 --> 00:28:28,300
+«Mutated» «Deleted» قليل بأعطيها «0.09» يعني «0.1
+
+252
+00:28:28,300 --> 00:28:34,660
+%» يعني عشرة بالمية هيك فتسعة بالمية «P» وعشرة
+
+253
+00:28:34,660 --> 00:28:43,020
+بالمية الـ «Q» كل المعادلات اللي بيحكونا دولةهو
+
+254
+00:28:43,020 --> 00:28:52,760
+أعقد مثال لـ «جين 1»، واضحة؟ دكتور، أسماء كانت
+
+255
+00:28:52,760 --> 00:28:57,000
+تسأل كيف الشقة التانية، بس يبدو وصلتها الفكرة
+
+256
+00:28:57,000 --> 00:29:00,880
+«كريم» بيقول يعني، «شو بتفيد دي هذه المعادلة؟»
+
+257
+00:29:00,880 --> 00:29:03,580
+يعني إيش المقصود بالـ frequency؟ مرة أخرى بيسأل
+
+258
+00:29:04,650 --> 00:29:14,370
+الآن نأتي مثلًا نأخذ موضوع دائمًا أحب أن نضرب مثال
+
+259
+00:29:14,370 --> 00:29:21,470
+عليه مثلًا، بنك الدم أنا
+
+260
+00:29:21,470 --> 00:29:31,630
+بهمني عشان أسهل إعطاء دم للناس حسب نسب الـA والـB
+
+261
+00:29:31,630 --> 00:29:39,000
+والـO groupبهمني يعني هذا مثال مش راح يظبط تماماً
+
+262
+00:29:39,000 --> 00:29:46,060
+مية بالمائة بس بدي أوصل فكرة معينة بالنسبة لما أنا
+
+263
+00:29:46,060 --> 00:29:50,460
+آجي كام نسبة الـA وكم نسبة الـO وكم نسبة الـB
+
+264
+00:29:50,460 --> 00:30:01,060
+بتفيدني يعني أنا مثلاً في بنك دم وبدي أجهز مثلاً
+
+265
+00:30:01,060 --> 00:30:07,490
+لمعركة أو لـأحتياجي في مدة طويلة أو كذا فبهمني
+
+266
+00:30:07,490 --> 00:30:15,770
+أعرف كام نسبة كل قليل موجود وقداش أجهز من هذا
+
+267
+00:30:15,770 --> 00:30:20,810
+وقداش أجهز من هذا، وش أعمل لك كذا ولي هيك فأحيانًا
+
+268
+00:30:20,810 --> 00:30:25,530
+لما تيجي و راح ناخد أمثلة أخرى لاستفادات لهذه
+
+269
+00:30:25,530 --> 00:30:35,870
+النسب أو لهذهالـ Frequency اللي هي يعني نسبة حدوث
+
+270
+00:30:35,870 --> 00:30:42,630
+أو احتمالية حدوثها تكون بشكل معين فالـ يعني اللي
+
+271
+00:30:42,630 --> 00:30:46,650
+بدك تاخده بس خلّينا نعدي هاي شوية بتشوف أنثى لي
+
+272
+00:30:46,650 --> 00:30:52,010
+كيف أشياء مفيدة أنك تعرف هذه الأرقام الـ P هي الـ
+
+273
+00:30:52,010 --> 00:31:04,380
+Frequency تبعت الـ Wild-type geneالـ Q هي نسبة الـ
+
+274
+00:31:04,380 --> 00:31:10,000
+Frequency تبع الـ Mutated Genes المثال اللي حطيناه
+
+275
+00:31:10,000 --> 00:31:17,260
+من قبل شوية اللي هو CCR5 وDelta CCR5 كانت النسب في
+
+276
+00:31:17,260 --> 00:31:23,140
+Population يعني أنا بفرجيكي إياها بهذا الشكل يعني
+
+277
+00:31:23,140 --> 00:31:24,060
+هذا مثال
+
+278
+00:31:28,510 --> 00:31:34,770
+لما درسوا في population
+
+279
+00:31:34,770 --> 00:31:41,550
+مختلفة في أماكن مختلفة في مدن وفي بلاد مختلفة ما
+
+280
+00:31:41,550 --> 00:31:49,970
+هي الـ Frequency تبعت الـ Delta CCR5أحنا حكينا
+
+281
+00:31:49,970 --> 00:31:57,670
+التقدير المتوسط حسب ذلك الدراسة 9% أو Point أو 10%
+
+282
+00:31:57,670 --> 00:32:03,010
+يعني هنا تقريبًا فاللي بدي أفرجيكيها إنه في
+
+283
+00:32:03,010 --> 00:32:08,490
+المناطق اللي تم دراسة الموضوع هذا بلاد مثلًا زي
+
+284
+00:32:08,490 --> 00:32:16,910
+هنا الصين «بنجلدش» الهند «باكستان» «سعودية»النسبة
+
+285
+00:32:16,910 --> 00:32:24,350
+لـ «CCR5» «Delta CCR5» اللي هو الـ Mutated Gene
+
+286
+00:32:24,350 --> 00:32:29,850
+كانت نسبة قليلة جداً، صفر في population معينة
+
+287
+00:32:29,850 --> 00:32:38,470
+بينما فيه لما ندرسه مثلاً في أماكن زي شمال أوروبا
+
+288
+00:32:38,470 --> 00:32:44,370
+في هذا المكان زي فنلندا والسويد والدانيمارك والـ
+
+289
+00:32:44,650 --> 00:32:49,350
+بولندا يمكن هنا لقوا
+
+290
+00:32:49,350 --> 00:32:56,690
+نسبة الـ Mutated Genes ضعف أو ضعف الـ 18% نسبة
+
+291
+00:32:56,690 --> 00:33:01,770
+عالية كثيرة فهذا حسب الدراسات يعني هنا هذه نوع من
+
+292
+00:33:01,770 --> 00:33:10,330
+الخارطة العالمية لتفاوت الـ population أنتم
+
+293
+00:33:10,330 --> 00:33:14,390
+تشاهدون الصورة الكاملةبما فيه الـ Caption تبعتها،
+
+294
+00:33:14,390 --> 00:33:23,510
+صح؟ الـ… هنا الـDelta CCR5 أليل
+in various
+
+295
+00:33:23,510 --> 00:33:27,810
+geographical regions in Europe وMiddle East
+
+296
+00:33:27,810 --> 00:33:31,790
+وIndian subcontinent في أماكن في العالم الصورة
+
+297
+00:33:31,790 --> 00:33:38,510
+بهذا الشكل بتخلى إنه نسبة حدوث لما ركزوا على إنهم
+
+298
+00:33:38,510 --> 00:33:43,880
+يهتموا بهذا النوع من الـGene Mutationلقوا إنه فيه
+
+299
+00:33:43,880 --> 00:33:51,420
+تفاوت بين البشر بالنسب بس هذه يعني نوع من بالأخير
+
+300
+00:33:51,420 --> 00:33:55,100
+يعني عرفوا يرسموا الصورة هذه من الـ Frequency تبعت
+
+301
+00:33:55,100 --> 00:34:02,720
+الـ Alleles اللي هي الـ P و الـ Q، ماشي؟ هنا اللي
+
+302
+00:34:02,720 --> 00:34:09,950
+ممثل بالرمز هنا هو الـ Q، ماشي؟وكل ما كانت نسبته
+
+303
+00:34:09,950 --> 00:34:16,870
+أكبر، شو اسمه؟ بتكون الأمور بهذا الشكل بس بدي أذكر
+
+304
+00:34:16,870 --> 00:34:23,990
+إنه هذا الآن على نموذج افتراضي اللي هو الـ Hardy
+
+305
+00:34:23,990 --> 00:34:28,350
+-Weinberg Law وبكون إنه population stable
+
+306
+00:34:28,350 --> 00:34:32,310
+population مافيش فيها migration مافيش فيها new
+
+307
+00:34:32,310 --> 00:34:38,390
+mutation الـ mating أو الزواج مفتوحفي كل الاتجاهات
+
+308
+00:34:38,390 --> 00:34:49,590
+فهو مثال على دراسة تمت أو دراسات تمت لفهم تفاوت
+
+309
+00:34:49,590 --> 00:34:57,510
+البشر في نوعية mutation معينة بطفرة معينة هنا بدنا
+
+310
+00:34:57,510 --> 00:35:02,630
+نسميها polymorphism يعني ما ما أقدر أعتبرها زي
+
+311
+00:35:02,630 --> 00:35:06,350
+الـGenetic mutation اللي هي very very very rare
+
+312
+00:35:06,960 --> 00:35:11,800
+اللي مثلًا طبعًا الـ Frequency للـ Polymorphism
+
+313
+00:35:11,800 --> 00:35:17,980
+بذكر هي الـ 1% إذا الواحد أكتر من 1% معناته
+
+314
+00:35:17,980 --> 00:35:26,540
+Frequent ماشي، في سؤال المعادلات
+
+315
+00:35:26,540 --> 00:35:32,360
+هذه أمثلة على كيف بعدين نستفيد من المعادلات بحيث
+
+316
+00:35:32,360 --> 00:35:37,270
+أنه يعني هذا راح نحتاجهفي قضية بن قوسين الـ
+
+317
+00:35:37,270 --> 00:35:45,590
+Genetic Counseling لما ييجي مثلًا عيلة عندهم مثلًا
+
+318
+00:35:45,590 --> 00:35:49,550
+مرض معين بيّن بالطفل الأول واتغلبوا اللّه بعدين
+
+319
+00:35:49,550 --> 00:35:55,110
+اللّه أخذوا داعته وتوفى الطفل الأول بيرجي لو كان
+
+320
+00:35:55,110 --> 00:36:02,320
+عندنا تصورما هو نوعية الـ Frequency تبع الـ Gene
+
+321
+00:36:02,320 --> 00:36:07,360
+Mutation؟ وما هو نوعية الـ Inheritance؟ وما هي
+
+322
+00:36:07,360 --> 00:36:12,310
+المعادلات التي استطيع استفيد منها؟ممكن أعطي
+
+323
+00:36:12,310 --> 00:36:17,030
+احتمالية تساعد الأهل هذولة أن يقرروا يخلفوا مرة
+
+324
+00:36:17,030 --> 00:36:21,490
+ثانية و لا ميخلفوش مرة ثانية و لا يعملوا إشي و لا
+
+325
+00:36:21,490 --> 00:36:25,610
+يتطلقوا و لا يبقى فيش داعي كام للزواج مع بعض و كذا
+
+326
+00:36:25,610 --> 00:36:31,250
+يعني احنا بنسوي نوع من هذا الأمر مثلا يعني اللي هو
+
+327
+00:36:31,250 --> 00:36:34,930
+فحص قبل الزواج بالنسبة لقضية الثلاثيميا وأمراض
+
+328
+00:36:34,930 --> 00:36:42,230
+الدمالثلاثيمية أو أمراض الدم تجد أنه يعني الأصل أن
+
+329
+00:36:42,230 --> 00:36:49,990
+الواحد ذا أثنين من الأشخاص الزوج والزوجة مقبلين
+
+330
+00:36:49,990 --> 00:36:55,830
+على الزواجإثنين هما عندهم طفرة بشكل معين بتخلّينا
+
+331
+00:36:55,830 --> 00:37:01,550
+ننصح إنه والله يعني اللي هي مبدأ حديث الرسول صلى
+
+332
+00:37:01,550 --> 00:37:06,190
+الله عليه وسلم «غربوا في النكاح أو تربوا لقدوا»
+
+333
+00:37:06,190 --> 00:37:11,110
+يعني لا تضمروا إنه يواحد يظل يخذ من أقاربه وإنه
+
+334
+00:37:11,110 --> 00:37:17,690
+يبعد في الزواج وكذا وكذا فهذه مبادئ يعني ترتبط بإن
+
+335
+00:37:17,690 --> 00:37:24,040
+الواحد يكون عنده تصور كام نسبحدوث كل نوع من الـ
+
+336
+00:37:24,040 --> 00:37:29,700
+Genotypes ويكون الـ Wild-type اللي هو الـ P والـ
+
+337
+00:37:29,700 --> 00:37:37,460
+والطفرة أو الـ Mutation اللي هي الـ Q وفي حالة الـ
+
+338
+00:37:37,460 --> 00:37:44,540
+Steady State في حالة لما يكون ما فيش يعني مغيرات
+
+339
+00:37:44,540 --> 00:37:50,050
+بتأثر على الموضوع هذا ويكون الأمور Stableبكون
+
+340
+00:37:50,050 --> 00:37:56,130
+مجموع القيم واحد تساوي كل total بتساوي واحد وتكون
+
+341
+00:37:56,130 --> 00:38:01,770
+بهذا الشكل، في أسئلة؟
+
+342
+00:38:01,770 --> 00:38:09,890
+في سؤال يا دكتور من كريم، بقول إنه ألجيت أنا لما
+
+343
+00:38:09,890 --> 00:38:16,980
+أعرف إن الـ frequency للأبوين هو Q4، هذا بيأثرمش
+
+344
+00:38:16,980 --> 00:38:27,480
+عارف هو إيه السؤال كان؟ شوف، بالنسبة للمن يكونوا
+
+345
+00:38:27,480 --> 00:38:32,720
+الـoffspring أو الـ4Q جزء و آسف، الـ4Q يمكن هذا
+
+346
+00:38:32,720 --> 00:38:38,280
+بيعني إنهم عرضة للطفرات أكثر من اللي عندهم الـ4B
+
+347
+00:38:38,280 --> 00:38:46,310
+يعني، بيسأل، يعني هيك صح الانستنتاج تبعه؟لأ لأ،
+
+348
+00:38:46,310 --> 00:38:57,450
+الآن شوف افرض خلّيني نرجع نشرحها مرة أخرى افرض الـ
+
+349
+00:38:57,450 --> 00:39:02,550
+«CCR5»
+
+350
+00:39:02,550 --> 00:39:08,670
+هذا الـ «فيتال» اللي أخدناه الـ Normal في 90% الـ
+
+351
+00:39:08,670 --> 00:39:10,770
+«CCR5» طيب
+
+352
+00:39:13,610 --> 00:39:20,430
+وإحتمالية الطفرة 10% خلّينا ناخدها بهذا الشكل،
+
+353
+00:39:20,430 --> 00:39:26,030
+تمام؟ دكتور أخلي كريم يسأل السؤال تبعه
+
+354
+00:39:30,570 --> 00:39:36,550
+نعم، أنا فاهم إن الـB معناته إنه لا يوجد فيه طفلة،
+
+355
+00:39:36,550 --> 00:39:43,450
+هذا شيء سائد، و الـQ هذا برمز للجيل المحيط، صحيح؟
+
+356
+00:39:43,450 --> 00:39:52,490
+برمز للـFrequency، للاحتمالية، كم تواجد هذا الجيل،
+
+357
+00:39:52,490 --> 00:39:58,710
+فإحنا مثلا، لو قلتلك، زي المثال اللي حكينا، شو
+
+358
+00:39:58,710 --> 00:40:10,670
+احتمالية؟إن إنسان عنده طفرتين، ماشي؟ بالنسبة لما
+
+359
+00:40:10,670 --> 00:40:18,850
+أنت تاخد مثل هذا المثال، ماشي؟ الآن، بالأخير الـP
+
+360
+00:40:18,850 --> 00:40:25,010
+هي الـFrequency اللي هي نسبة حدوث إنه يكون CCR5
+
+361
+00:40:25,010 --> 00:40:33,870
+فهي 90%، Point Nineوالـ «دلتا CCR πاي» point one
+
+362
+00:40:33,870 --> 00:40:39,630
+يعني عشرة بالمئة نفترض هيك نقربها ماشي فأنا لو
+
+363
+00:40:39,630 --> 00:40:47,730
+سألتك قداش احتمالية واحد يكون عنده طفرتين راح تقول
+
+364
+00:40:47,730 --> 00:40:53,490
+لي point one to point one بتساوي point O one فهذه
+
+365
+00:40:53,490 --> 00:40:59,840
+النسب اللي أنا بتوقعها لأن هناB تربية اللي هي الـ
+
+366
+00:40:59,840 --> 00:41:07,580
+P هذه تربية وهنا Q تربية وهنا 2PQ بس لو جبنا
+
+367
+00:41:07,580 --> 00:41:14,760
+بالمثال هذا شو احتمالية الـ الـ الأم إذا اعتبرنا
+
+368
+00:41:14,760 --> 00:41:21,160
+احتمالية الـ A الواحدة هي P ماشي فشو احتمالية واحد
+
+369
+00:41:21,160 --> 00:41:29,490
+dominant AA mother تتزوج dominantالـ AA father راح
+
+370
+00:41:29,490 --> 00:41:34,910
+يصير أنه يعني لما تيجي تاخد بالـ population مثلا
+
+371
+00:41:34,910 --> 00:41:45,690
+هي 90% ماشي 90% الـ A الـ dominant و الـ A small 0
+
+372
+00:41:45,690 --> 00:41:52,810
+.1 إذا أخدتها فشو احتمالية أنه يكونوا AA capital
+
+373
+00:41:52,810 --> 00:42:01,300
+إذا تضرب P تربيعوهذه P تربية فالاحتمالية لـ
+
+374
+00:42:01,300 --> 00:42:05,100
+Frequency تبعت الـ AA والـ Offspring كلهم راح
+
+375
+00:42:05,100 --> 00:42:08,720
+يكونوا Capital A Capital A راح يكونوا بهذا الشكل
+
+376
+00:42:08,720 --> 00:42:15,600
+ماشي فإذا بتاخدها population معينة راح تلاقي
+
+377
+00:42:15,600 --> 00:42:22,920
+نسبتهم في ال population P تقعيد أو قصر أربعة راح
+
+378
+00:42:22,920 --> 00:42:28,460
+تلاقيها بهذا الشكل يعنيإذا 90% في 90% في Ipoint 81
+
+379
+00:42:28,460 --> 00:42:34,900
+في Ipoint 81 راح يطلع حوالي 64% من الـ Population
+
+380
+00:42:34,900 --> 00:42:41,080
+يعني هاي النسب لنوعية
+
+381
+00:42:41,080 --> 00:42:47,000
+الـ Mating يعني النسب المتوقعهذه أحيانًا معلومات
+
+382
+00:42:47,000 --> 00:42:51,200
+مهمة ومفيدة حكيت بالنسبة للـ Genetic Counseling
+
+383
+00:42:51,200 --> 00:42:57,420
+بالنسبة ل… يعني راح نأخذ تطبيقات إلها في أفكار
+
+384
+00:42:57,420 --> 00:43:02,520
+معينة بس حتى يظبط الكلام هذا نرجع مرة ثانية، بدك
+
+385
+00:43:02,520 --> 00:43:05,960
+تنتبه إنه لازم تكون الـ Population في Steady State
+
+386
+00:43:05,960 --> 00:43:13,060
+والـ Netting مسموح، مافيش أي محددات عليه، لأنه فيه
+
+387
+00:43:13,060 --> 00:43:17,800
+كمان محدداتتخرب على الموضوع هذا، أيوة كريم، في
+
+388
+00:43:17,800 --> 00:43:23,020
+عندك سؤال؟ إن شاء الله واضحة كمان، نقطة بس صغيرة،
+
+389
+00:43:23,020 --> 00:43:25,960
+في الـ يكون الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+390
+00:43:25,960 --> 00:43:26,480
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+391
+00:43:26,480 --> 00:43:29,200
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+392
+00:43:29,200 --> 00:43:29,400
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+393
+00:43:29,400 --> 00:43:29,840
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+394
+00:43:29,840 --> 00:43:32,600
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+395
+00:43:32,600 --> 00:43:32,600
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+396
+00:43:32,600 --> 00:43:33,300
+الـ الـ الـ الـ الـ الـ
+
+397
+00:43:36,500 --> 00:43:40,900
+بيكون عندي جنسيات جيبحي زي اللي في النص ليش بنحط
+
+398
+00:43:40,900 --> 00:43:45,840
+اتنين جاب اللي بيقولوا انها علاقة معينة اشي هادا؟
+
+399
+00:43:45,840 --> 00:43:52,540
+الاحتمالية يكون من هذا النوع لما انت تاخد capital
+
+400
+00:43:52,540 --> 00:43:59,280
+A، small a تزاوج مع capital A، small a يعني لما
+
+401
+00:43:59,280 --> 00:44:03,900
+تاخد انت اللي هو المثال هذا شايف الخط اللي أنا
+
+402
+00:44:03,900 --> 00:44:04,740
+بأشير عليه؟
+
+403
+00:44:08,000 --> 00:44:15,040
+ماشي، ماشي، احتماليات
+
+404
+00:44:15,040 --> 00:44:18,720
+للناتج،
+
+405
+00:44:18,720 --> 00:44:30,680
+ماشي، بالنسبة للنسب، راح تكون، يعني، راح تقول، أنت
+
+406
+00:44:30,680 --> 00:44:34,260
+أصلا بتقول بالأول capital A، capital A هي الربع
+
+407
+00:44:34,990 --> 00:44:40,310
+وSmall a Small a هي الربع والـ Capital A Small a
+
+408
+00:44:40,310 --> 00:44:47,790
+هي النصف، إيه راح تقول نتيجة؟ فلما تأخذها برموز،
+
+409
+00:44:47,790 --> 00:44:58,650
+يعني إذا تردنا إن الأمور Stable اللي هو 8 أو 4 بيه
+
+410
+00:44:58,650 --> 00:45:04,440
+تربيع، Q تربيع بتسوي واحديعني لو كان اتنينهم fifty
+
+411
+00:45:04,440 --> 00:45:10,300
+-fifty percent بتكون راح تكون النسب ربع ونص وربع،
+
+412
+00:45:10,300 --> 00:45:17,860
+مش هيكت؟ فهي الفكرة
+
+413
+00:45:17,860 --> 00:45:29,390
+هنا اللي احنا أنا لسه بتجاوز قضية سائد ومتنحيبشكل
+
+414
+00:45:29,390 --> 00:45:34,870
+يعني أنا مش هنا بس بتكلم لما يكون عندك صفة وراثية
+
+415
+00:45:34,870 --> 00:45:41,970
+سائد أو متنحي أنا بتكلم على نسبة أنه زي مثلا
+
+416
+00:45:41,970 --> 00:45:45,710
+الـGene تبع الـCCR5 هذا اللي اتكلمنا عنه كميتال
+
+417
+00:45:45,710 --> 00:45:51,970
+كيف أنه في ال population فيه تفاوت بينهم حسة ليش
+
+418
+00:45:51,970 --> 00:45:57,890
+قال هو سائد ومتنحيالسائل اللي عنده سائد أو الطبيعي
+
+419
+00:45:57,890 --> 00:46:02,670
+فيه gene expression فهيتلاقي protein للـReceptor
+
+420
+00:46:02,670 --> 00:46:08,990
+هذا والله علم شو بيشتغل الـCCR5Delta اللي هي
+
+421
+00:46:08,990 --> 00:46:15,710
+الـMutated Alien هل هو مرض؟ هل هو يمثل إعاقة يعني؟
+
+422
+00:46:15,710 --> 00:46:19,770
+لأ، بس هو الـGene موجود في المجتمع بدنا ندرس قداش
+
+423
+00:46:19,770 --> 00:46:27,750
+هو والمثال اللي بنحكيه هنا اللي هو لـيعني دراسة عن
+
+424
+00:46:27,750 --> 00:46:33,550
+هذا الموضوع وقداش نسبهم بين الـ «populations»
+
+425
+00:46:33,550 --> 00:46:41,190
+المختلفة، ماشي؟ خلّيني أنا أنني أخد أمثلة تانية،
+
+426
+00:46:41,190 --> 00:46:46,690
+يمكن تتوضح الأمور أكتر، أيوة، احكي «الجين المتلحح
+
+427
+00:46:46,690 --> 00:46:52,310
+يعطيك ضفرة أو مرض» نعم «الجين
+
+428
+00:46:52,310 --> 00:46:56,180
+المتلحح يعطيك ضفرة أو مرض»أه طبعاً لأ ما .. ما ..
+
+429
+00:46:56,180 --> 00:47:02,700
+يعني مثلاً لما تقول الـ A B O system ماشي الـ O شو
+
+430
+00:47:02,700 --> 00:47:08,580
+ضررها؟ شو قملك؟ صح في حالات معينة بتسببلك مشكلة
+
+431
+00:47:08,580 --> 00:47:12,760
+معينة اللي انت كدهاش تعطي بالنقل شغل معين بس اللي
+
+432
+00:47:12,760 --> 00:47:18,040
+كإنسان طبيعي هيك ماشي أمان الله وإنسان طبيعي شو
+
+433
+00:47:18,040 --> 00:47:23,690
+هتفرد؟يعني حسا مثلا يعني إذا بتأمل أنكم منتبهين
+
+434
+00:47:23,690 --> 00:47:27,330
+للـCorona أو مع الـCorona مين الـBlood group اللي
+
+435
+00:47:27,330 --> 00:47:34,270
+فيها مشكلة مع الـCorona؟ بيقولوا الـO ينتهي أكتر
+
+436
+00:47:34,270 --> 00:47:39,370
+أظن الـA بيحكوا ولا الـO؟ أظن يعني في Blood group
+
+437
+00:47:39,370 --> 00:47:47,770
+بيقولوا إنه بيموتوا أكتر، بتسبب مرض أشد، حسا الآن
+
+438
+00:47:48,230 --> 00:47:53,330
+أحيانًا وأنا بتكلم عن الجين وبدور عليه وبعمل دراسة
+
+439
+00:47:53,330 --> 00:47:57,950
+وكذا ما بكونش فاهم كل الصورة تمامًا يعني فهذا اللي
+
+440
+00:47:57,950 --> 00:48:07,990
+أنا بحاول أني أسويه، ماشي؟ النقطة اللي بعدها لسه
+
+441
+00:48:07,990 --> 00:48:13,920
+الـ Gene Frequency اللي حكينا عنهاهذه على الـ
+
+442
+00:48:13,920 --> 00:48:19,920
+Autosomal Genes وهذه لما حكينا 0.9 للـ Wild-type
+
+443
+00:48:19,920 --> 00:48:30,520
+Genes و0.1 للـ Mutated Genes مثلا من الطفرة معينة
+
+444
+00:48:30,520 --> 00:48:36,320
+لسه هذا كمان النسب راح تكون طريقتها مختلفة بالنسبة
+
+445
+00:48:36,320 --> 00:48:42,810
+لما يكون عندي X-linked Genes الـ X-linked Genesلما
+
+446
+00:48:42,810 --> 00:48:49,210
+أنا أحط الـ Frequency يعني
+
+447
+00:48:49,210 --> 00:48:54,030
+كمثال هنا على الـ Color Blindness اللي هو Vision
+
+448
+00:48:54,030 --> 00:49:03,370
+اللي هو عمل ألوان تبع الإبصار فالـ لما ناخد على
+
+449
+00:49:03,370 --> 00:49:06,610
+الـ X-Chromosome ماشي
+
+450
+00:49:08,580 --> 00:49:12,440
+وهنا نيجي طبعاً بسبب إنه الـ males عندهم one copy
+
+451
+00:49:12,440 --> 00:49:19,740
+بس فإذا كان الـ X wild type اللي هو الجين العادي
+
+452
+00:49:19,740 --> 00:49:29,840
+بيكون normal color بجنها هي نسبتها 92% كجين الذكور
+
+453
+00:49:29,840 --> 00:49:39,830
+ماشي نسبة ال color blindness 0.08 يعني 8%الـQ،
+
+454
+00:49:39,830 --> 00:49:44,750
+اللي هي نسبة الـGene الـMutation تبع الـColor
+
+455
+00:49:44,750 --> 00:49:53,110
+Blinds one copy بتكون بتكفي حتى يكون عندنا مرض عند
+
+456
+00:49:53,110 --> 00:49:58,610
+الرجال أو عند الذكور بسبب أنه it is X-linked
+
+457
+00:49:58,610 --> 00:50:03,350
+recessive والـFrequency تبعته هي 8 بالمينيو لو
+
+458
+00:50:03,350 --> 00:50:12,710
+سألنا شو نسبةإذا هي الـ Frequency للقليل 92% يعني
+
+459
+00:50:12,710 --> 00:50:16,810
+هي Polymorphism نعتبرها Mutation، هي ليست
+
+460
+00:50:16,810 --> 00:50:21,130
+ميوتاشيا، نعتبرها شيء موجود وبالـ Steady State
+
+461
+00:50:21,130 --> 00:50:28,230
+موجود بهذه النسبة شو نثبت إن أنت تكون Color Blind؟
+
+462
+00:50:28,230 --> 00:50:37,390
+فرح نقول 8% تربية، اللي هي 64 من 10000ماشي يعني
+
+463
+00:50:37,390 --> 00:50:45,930
+حوالي 0.05% مثلا 0.06% أو 0.01% يعني اللي هو نسبة
+
+464
+00:50:45,930 --> 00:50:53,470
+هذه يعني اللي هي هاي بتعطينا اللي … اللي يكون
+
+465
+00:50:53,470 --> 00:50:59,370
+female الـ not completely normal homozygous normal
+
+466
+00:50:59,370 --> 00:51:06,320
+راح يكون 0.9التربيه اللي هو المسبة هذه اللي هتكون
+
+467
+00:51:06,320 --> 00:51:11,760
+Carrier فيه Normal Heterozygous أو Combined Normal
+
+468
+00:51:11,760 --> 00:51:19,260
+Heterozygous اللي هو 2PQ بتكون هالجدة وNormal اللي
+
+469
+00:51:19,260 --> 00:51:28,180
+هو Combined بتلاقي يعني شو اللي هنا بيحكوه لما أنا
+
+470
+00:51:28,180 --> 00:51:34,960
+آجي على مستوى الـGene Frequencyالـ الـ الـ الـ الـ
+
+471
+00:51:34,960 --> 00:51:35,200
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+472
+00:51:35,200 --> 00:51:35,300
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+473
+00:51:35,300 --> 00:51:35,640
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+474
+00:51:35,640 --> 00:51:36,260
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+475
+00:51:36,260 --> 00:51:44,820
+الـ الـ الـ الـ الـ الـ الـ الـ
+
+476
+00:51:44,820 --> 00:51:48,600
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+477
+00:51:48,600 --> 00:51:48,620
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+478
+00:51:48,620 --> 00:51:50,400
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+479
+00:51:50,400 --> 00:51:50,520
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+480
+00:51:50,520 --> 00:51:56,100
+الـ الـ
+
+481
+00:51:56,100 --> 00:52:04,850
+الـفاللي هو بيكون نسبته 2PQ اللي هو 0.147 الـ
+
+482
+00:52:04,850 --> 00:52:09,130
+«morphologically» أو الـ «phenotypically» «normal»
+
+483
+00:52:09,130 --> 00:52:12,990
+هو هذه المجموعة زائد هذه المجموعة فتجمع هذول
+
+484
+00:52:12,990 --> 00:52:19,750
+الرقمين بيطلع 0.9936% يعني راح يطلع لك الرقم هذا،
+
+485
+00:52:19,750 --> 00:52:23,930
+مجموع هاي زائد هاي والـ «colorblind» بالـ «female»
+
+486
+00:52:24,820 --> 00:52:31,660
+اللي راح تكون Q تغبيع اللي هو راح يطلع على فرق جدا
+
+487
+00:52:31,660 --> 00:52:38,220
+فهذا المثال يعني لما نيجي ناخد بالنسبة كـ Male لـ
+
+488
+00:52:38,220 --> 00:52:44,180
+X-linked recessive genotype لما ناخدها راح تكون
+
+489
+00:52:44,180 --> 00:52:47,920
+الـ frequency هي الـ frequency تبعت الـ genes في
+
+490
+00:52:47,920 --> 00:52:54,460
+الـ population 0.92% و0.08% راح أشوف إشي زي ذلك
+
+491
+00:52:55,280 --> 00:53:04,500
+ماشي فهذا مثال برضه على استخدام التعقيدات بالنسبة
+
+492
+00:53:04,500 --> 00:53:12,000
+للموضوع هذا على افتراض أولاً إنه الـ Hardy
+
+493
+00:53:12,000 --> 00:53:17,960
+-Weinberg equation أو law اللي هو بيفترض إن الـ
+
+494
+00:53:17,960 --> 00:53:22,360
+population stable الـ mutation مافيش إشي زديد
+
+495
+00:53:22,360 --> 00:53:28,110
+مافيش migrationالـ Mating مسموح بيه بين كل الأفراد
+
+496
+00:53:28,110 --> 00:53:37,470
+بشكل طبيعي فيها أسئلة؟
+
+497
+00:53:37,470 --> 00:53:42,410
+الآن لما
+
+498
+00:53:42,410 --> 00:53:49,550
+نقول إن زي المشكلة قبل شوية اللي هي أو الملاحظة
+
+499
+00:53:49,550 --> 00:53:54,960
+قبل شوية اللي هولو أخذنا الـ Color Vision
+
+500
+00:53:54,960 --> 00:54:02,480
+Blindness أو عمل ألوان أو Normal Vision، ماشي؟ هذه
+
+501
+00:54:02,480 --> 00:54:09,940
+ظاهرة Very Frequently وموجودة ولمّا بلاقيها موجودة
+
+502
+00:54:09,940 --> 00:54:18,620
+عند الناس، ماشي؟ بلاقيها كـ يعني على أساس إنه حتى
+
+503
+00:54:18,620 --> 00:54:23,620
+اللي عنده Color Blindnessبإمكانه يتزاوج وبإمكانه
+
+504
+00:54:23,620 --> 00:54:29,020
+يخلف وما بتأثرش في حياته وبقيش تقريبًا حياة طبيعية
+
+505
+00:54:29,020 --> 00:54:34,040
+يعني بس شوية صعوب أنه يفرق بين الأحمر والأخضر ولا
+
+506
+00:54:34,040 --> 00:54:41,240
+بين اللونين ولا كذا ولا هيك في أحيانًا نتكلم على
+
+507
+00:54:41,240 --> 00:54:44,780
+الأمراض
+
+508
+00:54:44,780 --> 00:54:53,720
+اللي نتيجة المرض بكون أنهالـ «جين» هذا ما راح يكمل
+
+509
+00:54:53,720 --> 00:55:01,060
+يعني أنا بالنسبة لي هدولا حاطين مجموعة إمراض شكل
+
+510
+00:55:01,060 --> 00:55:08,320
+معين بس «استيوجينيساس إمبرفكتر» هذا مرض كان عندنا
+
+511
+00:55:08,320 --> 00:55:12,960
+و أنا كنت طالب طب في مستشفى مبارك في الكويت كانت
+
+512
+00:55:12,960 --> 00:55:19,320
+مريضة مقيمة في المستشفى عندها هشاش سديدي جدا جدا
+
+513
+00:55:19,320 --> 00:55:26,350
+في العظاميعني مجرد مرات تقح، بنكسر العظيم تشدها أو
+
+514
+00:55:26,350 --> 00:55:31,810
+تسلم عليها بيدك بقوة، بنكسر العظيم فعندها شاشة
+
+515
+00:55:31,810 --> 00:55:36,730
+شديدة في العبام المريضة كان يمكن عمرها 25 سنة
+
+516
+00:55:36,730 --> 00:55:44,190
+طبعاً الملاحظ إلها إذا بتفرجيكم صور إلها لهذه
+
+517
+00:55:44,190 --> 00:55:49,750
+الحالة Astrogenesis imperfecta بتلاقي لون العيون
+
+518
+00:55:49,750 --> 00:55:57,740
+زرقالبياض العين، يعني خلّينا نفرجيكم صورتها
+
+519
+00:55:57,740 --> 00:56:05,500
+أستيوجينيــــــــــــــــــــــ
+
+520
+00:56:42,760 --> 00:56:51,580
+فمريضتي إذا شايفين الصورة هذه معاي شايفينها هي
+
+521
+00:56:51,580 --> 00:56:56,890
+يمكن امرأة عمرهاعشرين ثانية وخمسة وعشرين ثانية على
+
+522
+00:56:56,890 --> 00:57:05,910
+wheelchair بهذا الشكل وعظامها مكسرة وكيبوسكوليوسيس
+
+523
+00:57:05,910 --> 00:57:12,290
+العظام بشكلها مش مظبوط وبتكون بشكل تعبان كتير
+
+524
+00:57:12,290 --> 00:57:16,390
+فالفكرة اللي
+
+525
+00:57:24,470 --> 00:57:32,050
+الفكرة أنه لما نكون مرض بالمثل هذه الحالة شو
+
+526
+00:57:32,050 --> 00:57:39,230
+احتمالية لو أنا عند الـ P و الـ Q وعندي
+
+527
+00:57:39,230 --> 00:57:44,970
+نسب لهذه الجينات في المجتمع ماشي، شو نسبتها
+
+528
+00:57:44,970 --> 00:57:49,430
+بالنسبة للمرض هذا؟ في حد بيقدر يقوللي؟
+
+529
+00:58:06,380 --> 00:58:15,160
+الـ على افتراض أنه هذا الـ يعني النقطة اللي بده
+
+530
+00:58:15,160 --> 00:58:23,040
+يصلها في الموضوع هذا اللي هي موضوع أن حدوث هذه
+
+531
+00:58:23,040 --> 00:58:29,760
+الطفرة بهذا الشكل وتواجدها في الإنسان بيكون
+
+532
+00:58:29,760 --> 00:58:39,650
+أحيانًا lethal type يعنيويكون مميت فالاستنتاج
+
+533
+00:58:39,650 --> 00:58:47,730
+من أن هذه الأمراض عبارة عن أمراض قاتلة خصوصًا
+
+534
+00:58:47,730 --> 00:58:52,370
+أحيانًا كثيرة زي الـ Chromosome of anomalies حتى
+
+535
+00:58:52,370 --> 00:58:56,290
+بالكون بالـ Embryon كثير من الـ Lethal وما بيكملش
+
+536
+00:58:56,290 --> 00:59:02,790
+في الجنين الأنواع من المشاكل هذه بالأخير راح تكون
+
+537
+00:59:03,280 --> 00:59:08,820
+كلها نتيجة تفرات جديدة عم تحدث في المجتمع يعني
+
+538
+00:59:08,820 --> 00:59:16,540
+high disorders لسبب إنه المصاب بهذه الحالة ما في
+
+539
+00:59:16,540 --> 00:59:21,780
+مجال إنه يتزوج بحيث يعطي، ينقل هذا المرض للأبناء
+
+540
+00:59:21,780 --> 00:59:25,640
+والبنات تبعيه فالـFrequency اللي بنحكي عنها الـD
+
+541
+00:59:25,640 --> 00:59:33,280
+والـQ والنسب هذه ما تنطبق هنا والسبب إنهما في مجال
+
+542
+00:59:33,280 --> 00:59:40,020
+إن هاي الحالة تكون نتيجة ورافة من الأب والأم لأن
+
+543
+00:59:40,020 --> 00:59:44,840
+ما في إنسان عنده هذا المرض وصل إنه يكون أب أو أم
+
+544
+00:59:44,840 --> 00:59:52,420
+يكون يقدر يتزوج أو حد يتزوجه، واضح؟ فأحياناً الـ
+
+545
+00:59:52,420 --> 01:00:01,140
+«هاي» لما يعني القصة اللي بدرسوها بالنسبة للموضوع
+
+546
+01:00:01,140 --> 01:00:07,930
+هذااللي هو بيسموه الـ Fitness اللي هو إنه هل هاي
+
+547
+01:00:07,930 --> 01:00:15,230
+الحالة أو المرض أو الشغل بتأثر على أهليته للزواج
+
+548
+01:00:15,230 --> 01:00:20,170
+على رغبة البشر الآخرين إنه يتزوجوهوا بتزوجوا منه
+
+549
+01:00:20,170 --> 01:00:26,470
+أو يزوجوه أو يتزوجها فلما يكون في عندي condition
+
+550
+01:00:26,470 --> 01:00:33,570
+بـ Zero Fitness يعني ما في احتمالية إنهبعد إصابة
+
+551
+01:00:33,570 --> 01:00:39,050
+إنسان بهذا المرض أو ولادته فيه لأنه مرض وراثي ما
+
+552
+01:00:39,050 --> 01:00:44,950
+في احتمالية إن هذا يكون ناقل للمرض بعدين لأن ماحدة
+
+553
+01:00:44,950 --> 01:00:53,810
+بيزوجوا بعدين يعني فهذه ظاهرة أخرى لما نشوف مثل
+
+554
+01:00:53,810 --> 01:01:00,170
+هذه نسبة احتمالية هذا المرض فهو نسبة يعني معتمد
+
+555
+01:01:00,170 --> 01:01:07,630
+على نسبةتكوّن ونشوء New Mutation لأنه ما في مجال
+
+556
+01:01:07,630 --> 01:01:15,490
+أن يكون نتيجة Transmission of الجين للأولاد
+
+557
+01:01:15,490 --> 01:01:24,050
+والبنات لأنه Lethal لأنه ما بيكون ممكن أنه ينقل
+
+558
+01:01:24,050 --> 01:01:31,130
+الـCCR5 Delta اللي هو الـMutation هذه ما أثرت على
+
+559
+01:01:31,130 --> 01:01:36,590
+واحدالـ Color Blindness كمثال آخر بالـ Males ولا
+
+560
+01:01:36,590 --> 01:01:42,310
+الـ Females وكذا برضه مش مأثرة الـ Blood Group مش
+
+561
+01:01:42,310 --> 01:01:48,310
+مأثرة يعني ما بتأثر على الـ Fitness تبع الإنسان
+
+562
+01:01:48,310 --> 01:01:59,590
+للزواج ونقل الوراتق للأبناء والبنات بعد ذلك يعني
+
+563
+01:02:00,870 --> 01:02:08,590
+التطبيق الآخر، في أسئلة؟
+
+564
+01:02:08,590 --> 01:02:15,330
+التطبيق
+
+565
+01:02:15,330 --> 01:02:19,170
+الآخر للمعلومات
+
+566
+01:02:19,170 --> 01:02:27,930
+هذه اللي هي أنك أنت لما تدرس قداش، نسب، أي شيء
+
+567
+01:02:28,700 --> 01:02:33,640
+بتلاقي يعني
+
+568
+01:02:33,640 --> 01:02:42,000
+بتلاقي معلومات تكون مفيدة كالطب ومجتمع وكيف ده
+
+569
+01:02:42,000 --> 01:02:48,300
+تتعامل مع الكثير من الأشياء فالنقطة التالية
+
+570
+01:02:48,300 --> 01:02:55,900
+بالنسبة لك مواضيع إنه حكينا عن الـV والـQ وكذابدأ
+
+571
+01:02:55,900 --> 01:03:02,780
+تكون في population معينة تكون في مجموعة معينة
+
+572
+01:03:02,780 --> 01:03:09,260
+أحيانًا الصورة اللي أخذناها قبل شويه لـEuropa وكذا
+
+573
+01:03:09,260 --> 01:03:19,180
+على اعتبار أنه كل بشر في مكان معين يعني مافيش
+
+574
+01:03:19,180 --> 01:03:26,150
+هالـMigration كتير، كل واحدبتزوجوا من بعض بخطوط
+
+575
+01:03:26,150 --> 01:03:32,110
+شويه فيه نوع من الـ isolation وهي يعني غصب عنها
+
+576
+01:03:32,110 --> 01:03:38,750
+أحيانًا بتحدث يعني مثلًا في أمريكا مثلًا بيتكلموا
+
+577
+01:03:38,750 --> 01:03:42,730
+على إن الأمريكان السود إيش إلهم؟ إيش الأمريكان
+
+578
+01:03:42,730 --> 01:03:48,050
+البيض؟ إلهم وراثة معينة؟ الأمريكان الأصليين
+
+579
+01:03:48,050 --> 01:03:54,380
+الهولود الحمر؟ إلهم إشي ثالث؟يعني حتى على مستوى
+
+580
+01:03:54,380 --> 01:04:00,600
+مرات يعني أنا مثلاً في أي مكان مثلاً في الأردن
+
+581
+01:04:00,600 --> 01:04:07,200
+نتلاقي مثلاً نتكلم والله العيل الأفلاني مثلاً
+
+582
+01:04:07,200 --> 01:04:12,400
+مفشور عندهم مثلاً في مثلاً
+
+583
+01:04:12,400 --> 01:04:19,830
+في حالة اللي بيسموهاتحسس من المواد المخدرة تبع الـ
+
+584
+01:04:19,830 --> 01:04:26,450
+General Anesthesia فالـ General Anesthesia Agents
+
+585
+01:04:26,450 --> 01:04:31,290
+أحيانًا بتسبب حالة شديدة جدًا جدًا وخطيرة جدًا ففي
+
+586
+01:04:31,290 --> 01:04:37,490
+عائلة معينة معروفين عنها في البلد وفي بالذات يعني
+
+587
+01:04:37,490 --> 01:04:41,550
+في منطقتنا وهدولة آه واللههذه العيلة عندهم الحالة
+
+588
+01:04:41,550 --> 01:04:46,530
+الإفلانية لما تعطيهم تخدير بدك تكون حذر جداً وبدك
+
+589
+01:04:46,530 --> 01:04:51,250
+تأخذ احتياطات وبدك تعمل كذا أحياناً إنك تعرف إن ال
+
+590
+01:04:51,250 --> 01:04:55,690
+population اللي أنت بتتعامل معها عندها حالة معينة
+
+591
+01:04:55,690 --> 01:05:01,870
+بيكون هذا قضية مهمة فالآن ناخد بعض الأمثلة لخمسة
+
+592
+01:05:02,170 --> 01:05:13,210
+طفرات أو خمس حالات أو شو اسمه بالنسبة لخمس أمراض
+
+593
+01:05:13,210 --> 01:05:20,170
+الأول اللي هو Sickle Cell Anemia الـSS Genotype
+
+594
+01:05:20,170 --> 01:05:27,330
+يعني خدوس أو وجود مرض Sickle Cell بالنسبة
+
+595
+01:05:27,330 --> 01:05:37,610
+لهنا حاطينالـ بالنسبة للـ African Americans
+
+596
+01:05:37,610 --> 01:05:44,570
+الأفارقة الأمريكان الأفارقة من أصول أفريقية الـ SS
+
+597
+01:05:44,570 --> 01:05:52,510
+Hemoglobin تقريبًا نسبته واحد في كل 400 شخص هذه
+
+598
+01:05:52,510 --> 01:05:59,770
+النسبة ماشي وعندما تيجي تأكسها يعني هي تمثل الـ
+
+599
+01:05:59,770 --> 01:06:07,680
+الـالـ Q تربيع فالـ هو أنا عشرين من عشرين يعني
+
+600
+01:06:07,680 --> 01:06:16,620
+واحد من العشرين من كل العشرين أمريكي
+
+601
+01:06:16,620 --> 01:06:22,240
+أفريقي من أصول أفريقية اللي عنده الـ Sickle Cell
+
+602
+01:06:22,240 --> 01:06:27,340
+Trait أو القليل فواحد من عشرين تطلع خمس بالمية
+
+603
+01:06:27,340 --> 01:06:35,860
+فالـ Q خمس بالميةوعشان هيك بيطلع واحد في اللي هو
+
+604
+01:06:35,860 --> 01:06:43,420
+من كل 400 بس من ناحية الثانية كام نسبة الـ
+
+605
+01:06:43,420 --> 01:06:52,160
+carriers لهذا الجين اللي هو 5%؟ راح تكون 25% في 95
+
+606
+01:06:52,160 --> 01:07:01,750
+% راح تطلع تقريباً 0.9 اللي هي راح تطلعواحد كل
+
+607
+01:07:01,750 --> 01:07:09,590
+أحداشر هذه النسبة على إذا أخذنا الـ Steady State
+
+608
+01:07:09,590 --> 01:07:17,670
+الـ Hardy-Weinberg Equation بنسبة نسبة حدوث المرض
+
+609
+01:07:17,670 --> 01:07:25,490
+ونسبة القليل الصورة
+
+610
+01:07:25,490 --> 01:07:30,670
+الموجودةأو الـGene الموجود، وشو نسبة قدوته وشو
+
+611
+01:07:30,670 --> 01:07:37,870
+نسبة اللي هي الـHeterozygous يعني اللي عندهم نسبة
+
+612
+01:07:37,870 --> 01:07:44,130
+الـCarrier يعني هو لنا بدا تكون اللي هم الواحد في
+
+613
+01:07:44,130 --> 01:07:51,910
+الـ11 بينما لمنطقة قريبة أو لمجموعة قريبة في
+
+614
+01:07:51,910 --> 01:07:58,650
+أمريكا اللي هم الـHispanics من أصولحسب أسبانية ومن
+
+615
+01:07:58,650 --> 01:08:07,610
+أصول يعني مختلفة من مش أفريقا، مش أفارقة النسبة
+
+616
+01:08:07,610 --> 01:08:14,450
+واحد في كل 40 ألف ونسبة الأليل frequency 0.005
+
+617
+01:08:14,450 --> 01:08:21,170
+ونسبة إن واحد يكون career 1% نسب أندر بكثير إنه
+
+618
+01:08:21,170 --> 01:08:27,750
+علاقة إنسان Hispanic في أمريكايكون Sickle Cell على
+
+619
+01:08:27,750 --> 01:08:32,510
+عكس الأفارقة فيه كلام كتير شوه همية الـ SS
+
+620
+01:08:32,510 --> 01:08:36,830
+-Hemoglobin وإنه كيف إن الـ «هيتروزايجست» تبعه
+
+621
+01:08:36,830 --> 01:08:41,710
+بيخلّي الإنسان مقاوم للملاريا وليش الأفارقة عنده
+
+622
+01:08:41,710 --> 01:08:46,770
+دي بالنسبة أكبر على أساس إن المناطق اللي كانوا
+
+623
+01:08:46,770 --> 01:08:51,390
+عايشين فيها فيها ملاريا كتيرة وهذا بيعطيك نوع من
+
+624
+01:08:51,390 --> 01:08:58,330
+المقاوم للملاريافالـ «high» لمثال الـ Sickle Cell
+
+625
+01:08:58,330 --> 01:09:04,190
+Anemia هيك الأقام بتقول فما جابوش نسبة الـ «white»
+
+626
+01:09:04,190 --> 01:09:11,310
+قداش وحتى الواحد يشوف بس فيه يعني على الأقل مئة
+
+627
+01:09:11,310 --> 01:09:17,030
+ضعف فرق بالنسبة لـ Sickle Cell Anemia بين الأفريقا
+
+628
+01:09:17,030 --> 01:09:25,150
+وبين الهسباني منينيجي ناخد على الـ Rhاللي هو All
+
+629
+01:09:25,150 --> 01:09:32,190
+Rh Negative Alleles هنا الـ Rh، بدكم تتذكروا إن
+
+630
+01:09:32,190 --> 01:09:38,550
+الـ Rh زي الـ ABO System PA وB وO الـ Rh هو ثلاث
+
+631
+01:09:38,550 --> 01:09:43,890
+جينات مترابطة الـ C والـ D والـ E وأهم واحد هو الـ
+
+632
+01:09:43,890 --> 01:09:52,730
+D لما نعطي الـ لما نعطيالمرأة الحامل لما راح
+
+633
+01:09:52,730 --> 01:09:57,190
+ناخذها الـ Rh-incompatibility باجي بعطيهم mainly
+
+634
+01:09:57,190 --> 01:10:02,990
+Anti-D لأن أهم واحد هو الـD فلما
+
+635
+01:10:02,990 --> 01:10:07,610
+درسوا الموضوع هذا يكون
+
+636
+01:10:07,610 --> 01:10:14,850
+الـRh نيجاتيف للكل اللي هو واحد لسته أقل تمثل اللي
+
+637
+01:10:14,850 --> 01:10:21,030
+هي يعني أحنا تقريباً كنا بيقول واحد لعشربالمتوسط
+
+638
+01:10:21,030 --> 01:10:24,850
+يعني أنا كنت أقول الـ Rh إن الواحد يكون Negative
+
+639
+01:10:24,850 --> 01:10:34,550
+هو احتمالية العشر فبالنسبة للـ Whites 1 في 6 نسبية
+
+640
+01:10:34,550 --> 01:10:39,590
+عالية في الـ African Americans 1 في 14 ممكن
+
+641
+01:10:39,590 --> 01:10:44,810
+مجموعهم يكون 1 ل 10 تقريباً بينما عند اليابانيين
+
+642
+01:10:44,810 --> 01:10:49,070
+أو اليابانيات أو اليابانيين 1 في 200
+
+643
+01:10:51,800 --> 01:10:58,260
+فإنما ناخد الـ Frequency للـ Heterozygous اللي هو
+
+644
+01:10:58,260 --> 01:11:02,500
+2PQ اللي هو في نهاية بالنسبالي يعني بيكون الإنسان
+
+645
+01:11:02,500 --> 01:11:08,540
+Carrier تقريبًا نص بالنسبة للـ African Americans
+
+646
+01:11:08,540 --> 01:11:16,820
+40% Carrier بينما اليابانيين 1 في 8 تقريبًا 1 في
+
+647
+01:11:16,820 --> 01:11:25,250
+10 يعني تقريبًافهذه نسب للـ Rh الـ Phenylketonuria
+
+648
+01:11:25,250 --> 01:11:30,910
+مرض ويراثي بالـ Metabolism يكون فيه نقص في إنزين
+
+649
+01:11:30,910 --> 01:11:36,150
+معين يخليهم يتسمموا من الـ Phenylalanine الـ Amino
+
+650
+01:11:36,150 --> 01:11:43,230
+Acid بيعمل preventable mental retardationيعني هذا
+
+651
+01:11:43,230 --> 01:11:48,250
+أنا في الأردن عضو في جمعية الـ جمعية الأردنية الـ
+
+652
+01:11:48,250 --> 01:11:55,250
+Phenylketonuria يعني عبارة عن مرض يعني الصراحة
+
+653
+01:11:55,250 --> 01:12:04,230
+عنده يعني احتكاك فيه يعني تقريباً عندنا واحد في
+
+654
+01:12:04,230 --> 01:12:11,130
+الـ 3000 بني آدم عنده Phenylketonuria إذا تمتشخيصه
+
+655
+01:12:11,130 --> 01:12:16,670
+بشكل مبكر وبشكل سليم وبطل ليأكل الخبز العادي
+
+656
+01:12:16,670 --> 01:12:20,930
+والبروتين العادي وعطيته Special Diet بعيش طبيعي
+
+657
+01:12:20,930 --> 01:12:26,410
+ويبنمه طبيعي ويكون طبيعي أما إن إذا انترك راح يكون
+
+658
+01:12:26,410 --> 01:12:34,750
+نتيجته إنه عنده Mental Retardation فالنسب إذا
+
+659
+01:12:34,750 --> 01:12:39,570
+بنشوففي سكوتلاندا، إحنا عندنا في الأردن بيقدروا
+
+660
+01:12:39,570 --> 01:12:47,210
+واحد في التلات تلات أي تقديراً فلما نشوف قداش نسب
+
+661
+01:12:47,210 --> 01:12:51,930
+للـ Incidents واحد بالخمس تلات، واحد بالمائتين ألف
+
+662
+01:12:51,930 --> 01:12:55,410
+في فنلاندا وواحد بالمائة وعشرة تلات تقريبا في
+
+663
+01:12:55,410 --> 01:13:02,650
+اليابان هنا بتمثل الأليل frequency ونسبة الـ
+
+664
+01:13:02,650 --> 01:13:07,080
+carriers يعنيفسكوتلاندا تقريبًا واحد في الأربعين
+
+665
+01:13:07,080 --> 01:13:13,160
+في فنلاندا واحد في الـ250 اليابان واحد في الـ150
+
+666
+01:13:13,160 --> 01:13:21,140
+تقريبًا 160 فهذه للـRecessive Disorders وهنا
+
+667
+01:13:21,140 --> 01:13:27,960
+الـRecessive Disorders أوضح بالنسبة لأنها كلها
+
+668
+01:13:27,960 --> 01:13:33,770
+Recessive Disorders وبتكون يعني الـالـ Q تربية هي
+
+669
+01:13:33,770 --> 01:13:39,010
+نسبة الحدوث للـ Disease لأن هذا اللي بدي يكون عنده
+
+670
+01:13:39,010 --> 01:13:46,050
+Two copies which are يعني effective بالنسبة
+
+671
+01:13:46,050 --> 01:13:49,170
+لبعض الـ Other diseases زي الـ «فاميلة
+
+672
+01:13:49,170 --> 01:13:53,810
+الهيبركوليستروليميا» و «myotonic dystrophy» الـ
+
+673
+01:13:53,810 --> 01:13:56,090
+«myotonic dystrophy»، «فاميلة الهيبركوليستروليميا»
+
+674
+01:13:56,090 --> 01:13:59,890
+واحد من هذه الـ «hyperlipidemias» وهذه الأرقام
+
+675
+01:13:59,890 --> 01:14:08,570
+عندكموالـ Myotonic Dystrophy اللي هو تشنج العضلات
+
+676
+01:14:08,570 --> 01:14:14,710
+ويكون خلل في العضلات تظلها مضطرة يعني مافيش
+
+677
+01:14:14,710 --> 01:14:21,090
+relaxation للعضلة النقطة وما فيها أنه اللي راح
+
+678
+01:14:21,090 --> 01:14:26,770
+أشوفه من عنده disease ماشي من هذا النوع لأن هذا
+
+679
+01:14:26,770 --> 01:14:35,280
+صفة ساعدة فهوالـ «Q» تربية نسبة الأليل المصاب
+
+680
+01:14:35,280 --> 01:14:40,180
+ونسبة الـ heterozygous مع بعض يعني هذه الـ
+
+681
+01:14:40,180 --> 01:14:48,220
+frequency اللي راح أشوفها تتمثل هذه الاحتمالية
+
+682
+01:14:48,220 --> 01:14:54,320
+فأنا لما نشوف مثلا واحد في كل 25 ألف أو واحد في كل
+
+683
+01:14:54,320 --> 01:14:57,970
+500 تقريبًاولا بالنسبة لـ Family of
+
+684
+01:14:57,970 --> 01:15:04,250
+Hypercholesterolemia واحد في السبعين في أفريقيا أو
+
+685
+01:15:04,250 --> 01:15:08,270
+في أمريكا واحد في الخمسمائة أو في كيندا واحد في
+
+686
+01:15:08,270 --> 01:15:18,330
+الـ122 فهذه النسب المتوقعة للقليل تبع الـDisease
+
+687
+01:15:18,330 --> 01:15:27,720
+تكون بهذا الشكل فيعني الأمريعني أحيانًا لما واحد
+
+688
+01:15:27,720 --> 01:15:32,020
+يتعامل مع الطب في population معينة بهمه يعرف إذا
+
+689
+01:15:32,020 --> 01:15:37,300
+فيه مميز لهم إذا فيه احتمالية أكبر لبعض الأمراض
+
+690
+01:15:37,300 --> 01:15:45,560
+أكتر من أمراض تانية والأصل الوزارة الصحية والمسح
+
+691
+01:15:45,560 --> 01:15:53,720
+الطبي والمسح الصحي في منطقة معينةإنه يكون على
+
+692
+01:15:53,720 --> 01:16:02,300
+انتباه لهذه الأمراض ونسبها ويكون يعني تصور لوجودها
+
+693
+01:16:02,300 --> 01:16:08,120
+وبالتالي يعني بيخلّي القطاع الصحي منتبه أكتر لشغل
+
+694
+01:16:08,120 --> 01:16:11,820
+عملته طريقة
+
+695
+01:16:11,820 --> 01:16:18,900
+يعني استفادة أخرى من هذا الموضوع هي قضية
+
+696
+01:16:21,530 --> 01:16:30,790
+في أسئلة على اللي تم من قبل؟ في أي استفسار؟
+
+697
+01:16:30,790 --> 01:16:39,230
+أموركم كويسة؟
+
+698
+01:16:39,230 --> 01:16:41,250
+طيب، نكمل
+
+699
+01:16:45,000 --> 01:16:53,100
+في سؤال من كريم بيقول الأرقام والنسب مش حفظ يعني
+
+700
+01:16:53,100 --> 01:16:58,060
+مطلوب فاهم كيف أجت وشو بنفهم منها بس طبعا، طبعا،
+
+701
+01:16:58,060 --> 01:17:04,480
+طبعا، ويعني النقطة الحقيقية المطلوبة من هذه
+
+702
+01:17:04,480 --> 01:17:09,550
+الأرقامقضية تفاوتها في نفس المجتمع يعني في المجتمع
+
+703
+01:17:09,550 --> 01:17:14,930
+الأمريكي والله نسبة الـ Sickle Cell لو كان إنسان
+
+704
+01:17:14,930 --> 01:17:20,130
+أبيض ولا أسود ولا أمريكي أصلي ولا كده كيف إنها أو
+
+705
+01:17:20,130 --> 01:17:28,390
+Hispanic population هذه ناحية مهمة وهذه بالنسبة
+
+706
+01:17:28,390 --> 01:17:37,310
+لهم ماشيةيعني أحيانًا إليها دخل بنسميه بالطب
+
+707
+01:17:37,310 --> 01:17:43,910
+الشخصي Personalized Medicine بصير أنا هنا من
+
+708
+01:17:43,910 --> 01:17:50,290
+المعلومات السابقة عن نسبة خدوث المرض الإفلاني في
+
+709
+01:17:50,290 --> 01:17:56,010
+المجموعة الإفلانية بتخليني أتنبأ أو أعرف جزء من
+
+710
+01:17:56,420 --> 01:18:01,280
+سواء نوعية المرض اللي عنده شدة المرض اللي عنده
+
+711
+01:18:01,280 --> 01:18:05,200
+احتمالية المرض اللي عنده فهذه أحيانًا معلومات
+
+712
+01:18:05,200 --> 01:18:08,920
+مفيدة جدًا وأحيانًا تستخدم حتى على مستوى الشخص
+
+713
+01:18:08,920 --> 01:18:15,260
+ماشي أنه إيش يعني في أمريكا مثلًا من الأشياء اللي
+
+714
+01:18:15,260 --> 01:18:21,380
+دائمًا بيسألوا عنها ويعني بيركزوا عليها قضية شو
+
+715
+01:18:21,380 --> 01:18:27,090
+أصولهاكوخازي يعني أبيض، احنا طبعاً البيض، العرب
+
+716
+01:18:27,090 --> 01:18:32,030
+بيعتبرونا كوخازيين يعني لما ناخد التصنيف، بس مش
+
+717
+01:18:32,030 --> 01:18:40,130
+أفريقي، مش هسباني أو إسباني، يعني مش طبعاً أصول
+
+718
+01:18:40,130 --> 01:18:46,610
+الصينية، Orientals، أصول هندية، مثلاً، بدك تشوف في
+
+719
+01:18:46,610 --> 01:18:53,240
+أي ناحية أحياناً مهمة في قضية توقعك للمرضماشي
+
+720
+01:18:53,240 --> 01:19:00,740
+دايمًا الأرقام ما هي يعني المهم فهم العلاقات بينها
+
+721
+01:19:00,740 --> 01:19:06,680
+وليش هي أجت وشو بتمثل ماشي أكثر من إنه شو هو الرقم
+
+722
+01:19:06,680 --> 01:19:18,920
+نفسه يعني إذا أنا أعطيتك مثلًا disease disease
+
+723
+01:19:18,920 --> 01:19:24,550
+recessiveوأعطيتك مثلًا إنه بيصيرك واحد من عشرة من
+
+724
+01:19:24,550 --> 01:19:31,850
+الـ population تقدر تجيب الـ Q إذا واحد من العشرة
+
+725
+01:19:31,850 --> 01:19:36,670
+من ال population عنده الـ disease، ماشي؟ فإذا
+
+726
+01:19:36,670 --> 01:19:38,470
+العشر هو
+
+727
+01:19:38,470 --> 01:19:45,730
+اللي’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’
+
+728
+01:19:49,770 --> 01:19:59,310
+هنا لما يكون مثلا 1 في الأربعمية معناته لو أخذناها
+
+729
+01:19:59,310 --> 01:20:06,290
+نسبة راح تطلع 1 بالعشرين ماشي لأنه الـ 1 في
+
+730
+01:20:06,290 --> 01:20:11,290
+العشرين إذا نسبة القليل في الـ population بيخليني
+
+731
+01:20:11,290 --> 01:20:16,290
+إن المصابين 1 بالأربعمية نسبة الـ carriers إذا 0
+
+732
+01:20:16,290 --> 01:20:26,260
+.05%اللي هي راح تطلع كنسبة Career 0.1 اللي هي 2PQ
+
+733
+01:20:26,260 --> 01:20:32,480
+ناشي، لما أضربن بعض النسب المفروض أطلق أرقام زي
+
+734
+01:20:32,480 --> 01:20:38,720
+هذه أظن يعني مش غلط أنه جدول زي هيك الواحد يقعد
+
+735
+01:20:38,720 --> 01:20:44,230
+يطلع مثلا شو نسبة الـPمثلاً لو هيك نخدها exercise
+
+736
+01:20:44,230 --> 01:20:49,190
+بعدين ونطلق نسبة الـP تبعت ال population تبعت
+
+737
+01:20:49,190 --> 01:20:53,330
+الأليل الأصلي أو اللي هو اللي مش مصارف دكتور في
+
+738
+01:20:53,330 --> 01:20:59,110
+سؤال سؤالين حتى في سؤال من معتز بيسأل كيف ال
+
+739
+01:20:59,110 --> 01:21:02,910
+career أجى يعني P كام نسبة يعني كيف ال career أجى
+
+740
+01:21:02,910 --> 01:21:07,670
+يعني بيسأل P كانت كام نسبتها مش مكتوبمش عارف إذا
+
+741
+01:21:07,670 --> 01:21:14,830
+كان جزده على الـ slide السابق اسمعلي، الآن
+
+742
+01:21:14,830 --> 01:21:22,710
+لما تيجي تاخد انت القاعد الأولى بالنسبة لل
+
+743
+01:21:22,710 --> 01:21:32,870
+equation ماشي أن الـ P زادي بـQ يسوى كم؟ يسوى واحد
+
+744
+01:21:32,870 --> 01:21:42,220
+فهم عليك إيه؟أنت لما تيجي تأخذ لك 100 بني آدم كام
+
+745
+01:21:42,220 --> 01:21:49,700
+نسخة من الجين راح تلاقي؟ راح فيه، عندي 200 نسخة،
+
+746
+01:21:49,700 --> 01:21:56,340
+صح؟ فأنا عندي 200 نسخة من الجين اللي هو زي «CCR»
+
+747
+01:21:56,340 --> 01:22:02,420
+سواء الـ «5» الأصلي أو الـ «Mutated» نفترض هيك،
+
+748
+01:22:02,420 --> 01:22:11,350
+صح؟فلما أنا عندي 200 نسخة أخدتها من 180 أدم ماشي،
+
+749
+01:22:11,350 --> 01:22:19,370
+نسبة هذا الـ Disease أو الـ Normal هذولا النسبتين
+
+750
+01:22:19,370 --> 01:22:25,370
+مجموعهم 100 أو 1 آسف، راح يكون مجموعهم 1 فلما أنا
+
+751
+01:22:25,370 --> 01:22:29,190
+أخد إن الـ P، الـ Q هنا Zero مثلا زي الـ Sickle
+
+752
+01:22:29,190 --> 01:22:35,880
+Cell في الـ African Americansالنتيجة هي 0.05 هذا
+
+753
+01:22:35,880 --> 01:22:40,240
+أليل frequency هذا على مستوى الـG لما أنا درست
+
+754
+01:22:40,240 --> 01:22:48,920
+الـ200 حالة اللي أنا قدرت أدرسهم فنتيجة الأمر هذا
+
+755
+01:22:48,920 --> 01:22:58,980
+راح يكون إنه مظهريًا كإنسان عنده مرض لهذه الحالة
+
+756
+01:22:58,980 --> 01:23:04,450
+زي في الـAfrican American هوواحد في الأربعمين اللي
+
+757
+01:23:04,450 --> 01:23:11,210
+هو بدك تحسبها وتشوف راح تطلع 0.0025 اللي هي واحد
+
+758
+01:23:11,210 --> 01:23:16,950
+في الأربعمين تضرب الـQ تربيه ناشط اللي هي الواحد
+
+759
+01:23:16,950 --> 01:23:22,330
+على الأربعمين شو نسبة الـCareers؟ واحد من عشرة
+
+760
+01:23:22,330 --> 01:23:29,350
+تقريبًا اللي هو راح تطلع 0.1 percent فالـ
+
+761
+01:23:30,120 --> 01:23:36,600
+الـ P و الـ Q نتكلم على نسبة القليل في دراسة أنت
+
+762
+01:23:36,600 --> 01:23:42,400
+تاخد كل أي إنسان عنده أثنين وأنا ما بعرف هو
+
+763
+01:23:42,400 --> 01:23:48,400
+الإنسان اللي أمامي هو Pure Capital A Capital A ولا
+
+764
+01:23:48,400 --> 01:23:52,600
+Capital A Small A ولا Small A Small A أنا لسه ما
+
+765
+01:23:52,600 --> 01:23:58,810
+بعرف بس كمجمل Capital A و Small A مجموعهمرح يكون
+
+766
+01:23:58,810 --> 01:24:04,190
+الـ Frequency 1 واضح؟ في أسماء برضه يعني بتسأل عن
+
+767
+01:24:04,190 --> 01:24:07,750
+قضية الـ Q تربيع مش عارف إيه بتسأل بتقول يعني كيف
+
+768
+01:24:07,750 --> 01:24:11,170
+كيف الـ Q تربيع كيف جاب النسبة تبعتها لإنها مش
+
+769
+01:24:11,170 --> 01:24:16,370
+جواب Q ضرب Q لأ ليش مش جواب؟ مش عارف أنا استغرب من
+
+770
+01:24:16,370 --> 01:24:21,650
+السؤال اللي أمامي لأ لأ انت حسبيها 1 على 400 رح
+
+771
+01:24:21,650 --> 01:24:30,850
+تطلع 0.0025 وضربيهاماشي راح تعطيكي شو اسمه الـ Q
+
+772
+01:24:30,850 --> 01:24:38,030
+تربيع ماشي الأرقام اللي قدامكم اشتغلوا عليها الـ 1
+
+773
+01:24:38,030 --> 01:24:43,610
+على 400 حوّلها لكسب يعني حوّلها لـ 0.0025 راح
+
+774
+01:24:43,610 --> 01:24:48,690
+تلاقي كيف تيجي ماشي رياضيا الأرقام مظبوطة اللي
+
+775
+01:24:48,690 --> 01:24:54,790
+قدامكم 100% يعني بس بدأ الواحد يفهم معنا شو الـ Q
+
+776
+01:24:54,790 --> 01:24:59,530
+شو الـ Pوليش الـ heterozygous يعني اللي هو الـ
+
+777
+01:24:59,530 --> 01:25:06,750
+career percentage بهذا الشكل، آه فلس تمام، أعتقد
+
+778
+01:25:06,750 --> 01:25:09,590
+الأمور واضحة بالنسبة للأشخاص اللي سألوا يعني هنا
+
+779
+01:25:09,590 --> 01:25:13,490
+ننتبه إنه لما نكون dominant إذا أنا عارف إنه
+
+780
+01:25:13,490 --> 01:25:18,750
+dominant ال incidence للـ disease هي الـ Q تربية
+
+781
+01:25:18,750 --> 01:25:25,720
+زي الـ 2PQ، هذه نسبة مجموعة أثنين، ماشي؟وإذا أنا
+
+782
+01:25:25,720 --> 01:25:31,900
+بقدر يعني تعطيني أي رقم لـ Incidence of an allele
+
+783
+01:25:31,900 --> 01:25:37,660
+أو mutation راح تلاقي، راح تكون هذه النسب صحيحة أو
+
+784
+01:25:37,660 --> 01:25:43,800
+مظبوطة يعني طيب، إذا خلصنا السؤال، الآن نيجي على
+
+785
+01:25:43,800 --> 01:25:52,390
+موضوع آخر استفادة من هذه الجانبيعني بالذات الأمر
+
+786
+01:25:52,390 --> 01:25:57,050
+في أمور الـ Genetics أحيانًا مربوط بالدول المتقدمة
+
+787
+01:25:57,050 --> 01:26:04,990
+حضارياً ومادياً وصحياً وطبياً بتلاقي يعني فيه
+
+788
+01:26:04,990 --> 01:26:09,330
+جوانب بتكلموا
+
+789
+01:26:09,330 --> 01:26:17,970
+عن يعني حقيقةً هي تقدم تقني في إمكانية عمل فكوصات
+
+790
+01:26:21,730 --> 01:26:28,770
+من أنواع الفحوصات هي طريقة يعني أنا كنت مرة ذكرت
+
+791
+01:26:28,770 --> 01:26:32,850
+معلومة من قبل فيه دراسات لما درسوا الـ
+
+792
+01:26:32,850 --> 01:26:38,930
+Mitochondrial Inheritance و Mitochondrial Diseases
+
+793
+01:26:38,930 --> 01:26:44,990
+أو Mitochondrial DNAلقينا طبعاً الـ mitochondrial
+
+794
+01:26:44,990 --> 01:26:49,690
+DNA بنتقلش إلا عن طريق الأم الأب ما إجوا دخلوا ومن
+
+795
+01:26:49,690 --> 01:26:54,970
+مصدر واحد يعني فقط عن طريق الأم في البويضة بتمنقل
+
+796
+01:26:54,970 --> 01:26:58,530
+الـ mitochondrial chromosome و الـ mitochondrial
+
+797
+01:26:58,530 --> 01:27:09,340
+DNA فنتيجة لما تيجي أنت تدرس يكون عندك آلةتقدر
+
+798
+01:27:09,340 --> 01:27:17,400
+تعمل نوع من الـGenetic Testing سواء باستخدام يعني
+
+799
+01:27:17,400 --> 01:27:27,460
+طبعاً باستخدام الـVCR باستخدام الـ… باستخدام أنه
+
+800
+01:27:27,460 --> 01:27:32,040
+عن طريق Enzymes بتقصوا الـDNA في أماكن معينة
+
+801
+01:27:34,990 --> 01:27:46,530
+فبيسموها يعني أنواع من الـ يعني من الآلات ماشية
+
+802
+01:27:46,530 --> 01:27:50,030
+تقدر
+
+803
+01:27:50,500 --> 01:27:55,180
+يعني بالنسبة للـ Mitochondrial DNA في الأخير،
+
+804
+01:27:55,180 --> 01:28:00,940
+النتيج اللي وصلوها إنه قدروا يثبتوا أو يشوفوا إنه
+
+805
+01:28:00,940 --> 01:28:06,800
+في الأخير كل البشر بيرجعوا لـ7 أمهات إنه كل البشر
+
+806
+01:28:06,800 --> 01:28:12,700
+إنه سبع أنواع من الـMitochondrial DNA أو
+
+807
+01:28:12,700 --> 01:28:18,180
+Mitochondrial Chromosomes وهذه السبع أنواع محفوظين
+
+808
+01:28:18,180 --> 01:28:26,750
+فيها إحناوإنه بالأخير يعني بتدعوا إنه بنرجع
+
+809
+01:28:26,750 --> 01:28:33,210
+بالأخير لسبع إنات كانوا هم مصدر البشرية كلها
+
+810
+01:28:33,210 --> 01:28:36,750
+أحياناً
+
+811
+01:28:36,750 --> 01:28:43,730
+يعني كناحي وراثية بس أهم من هيك إنه الـ
+
+812
+01:28:47,150 --> 01:28:57,710
+إذا عندي أنا آليات، أجهزة، إمكانات في يعني في
+
+813
+01:28:57,710 --> 01:29:00,790
+الولايات المتحدة الأمريكية أو بريطانيا أو أوروبا
+
+814
+01:29:00,790 --> 01:29:09,010
+أحيانًا بيصير الواحد يقول أنا بدي أفهم أنا شوه
+
+815
+01:29:09,010 --> 01:29:15,530
+أصولي يعني في أمريكا للحظة معينة يعني في التاريخ
+
+816
+01:29:15,530 --> 01:29:24,620
+العجوديةكان عندهم إنه الأسود هو اللي نسبة السواد
+
+817
+01:29:24,620 --> 01:29:31,880
+فيه أكثر من واحد في ستاشر واحد من ستاشر يعني إذا
+
+818
+01:29:31,880 --> 01:29:41,720
+أبوه أسود أو أمه سودة فنسبة السواد فيه نص أو واحد
+
+819
+01:29:41,720 --> 01:29:49,670
+على اتنين إذا جدودهإذا الربع
+
+820
+01:29:49,670 --> 01:29:56,270
+يعني هم أربعة إذا واحد أسود بيظلوا بيعتبروا أسود
+
+821
+01:29:56,270 --> 01:30:03,410
+إذا واحد أبو جدوده واحد أسود مش مشكلة ما
+
+822
+01:30:03,410 --> 01:30:08,570
+بيعتبروهوش أسود طبعاً في الحالة هذه بيكون أقل من
+
+823
+01:30:08,570 --> 01:30:16,160
+واحد من تمانية ماشي؟فطلعت شغلة إنه إحنا من وين
+
+824
+01:30:16,160 --> 01:30:21,820
+جينا وشو نسبة ال .. يعني .. يعني ده الواحد بتطلع
+
+825
+01:30:21,820 --> 01:30:25,000
+على .. لما بيكونوا يتطلعوا على وجه الناس وكنا خلقة
+
+826
+01:30:25,000 --> 01:30:29,840
+ربنا وكنا كويسين بتلاقي مثلا في أمريكا السود اللي
+
+827
+01:30:29,840 --> 01:30:33,060
+من أمريكا .. في أمريكا نفسهم اللي انتهوا وجاي أسود
+
+828
+01:30:33,060 --> 01:30:38,060
+بتلاقي سواده شديد وشكله بشكل معين السود اللي في
+
+829
+01:30:38,060 --> 01:30:41,650
+أمريكا والله فيه نسبة كبيرة منهمبتقول عنه أنا عارف
+
+830
+01:30:41,650 --> 01:30:49,010
+هذا مخلط يعني أذا نائبة المرشح «بايدن» تبع أمريكا
+
+831
+01:30:49,010 --> 01:30:55,010
+بالانتخابات بتلاقيها يعني هي تقريبًا بيضة يعني مش
+
+832
+01:30:55,010 --> 01:31:02,110
+تودة كتير كتير كتير بس مش بيضة يعني على نفس الخطة
+
+833
+01:31:02,110 --> 01:31:08,530
+في الأدوات
+
+834
+01:31:09,240 --> 01:31:16,700
+في نفس الـ… يعني نسميها
+
+835
+01:31:16,700 --> 01:31:23,800
+أدوات أو فحوصات بتبين ليه لما إحنا نتكلم على وندور
+
+836
+01:31:23,800 --> 01:31:30,680
+على«ancestry informative markers» يعني على مؤشرات
+
+837
+01:31:30,680 --> 01:31:37,050
+معينةحاولوا من خلال دراسات من قبل جابوا أبيض أبيض
+
+838
+01:31:37,050 --> 01:31:42,650
+مظبوط وPure من كذا generation عرقيل وأسود Pure من
+
+839
+01:31:42,650 --> 01:31:47,870
+كذا generation وHispanic وأجوا درسوا الموضوع هذا
+
+840
+01:31:47,870 --> 01:31:52,510
+لقينا إنه مثلا في البيض
+
+841
+01:31:55,620 --> 01:32:00,080
+الغالبية العظمى من المؤشرات بتلاقيها باللون الأزرق
+
+842
+01:32:00,080 --> 01:32:06,640
+بهذا الشكل وعطوها لمعنى معين بالنسبة للـ African
+
+843
+01:32:06,640 --> 01:32:10,920
+Americans يعني الدولة بالسود بكونوا بهذا الشكل الـ
+
+844
+01:32:10,920 --> 01:32:15,460
+European Americans اللي من أصول أوروبية بتلاقيهم
+
+845
+01:32:15,460 --> 01:32:20,660
+بهذا الشكل ولمّا درسوا مجموعة ثالثة لقوها بهذا
+
+846
+01:32:20,660 --> 01:32:27,190
+الشكلفإذا واحد في أمريكا وعنده مثلًا ألف دولار
+
+847
+01:32:27,190 --> 01:32:33,830
+مقدر يدفعهم للمختبر بدرس هذه الـ Markers هدولة
+
+848
+01:32:33,830 --> 01:32:39,930
+وبطلعوله report أنت والله خمسين بالمية أبيض تلاتين
+
+849
+01:32:39,930 --> 01:32:49,140
+بالمية أسود عشرة بالمية مثلًايهودي مثلاً أو Middle
+
+850
+01:32:49,140 --> 01:32:56,520
+Eastern 10% صيني وبيعطوه نسب شو هو تركيبته الجينية
+
+851
+01:32:56,520 --> 01:33:03,120
+الوراطية من ناحية زي هيك يعني هذه يعني ما بعرف
+
+852
+01:33:03,120 --> 01:33:11,340
+طبياً مدى أهميتها أو يعني هي مؤشر كيف البشر كلنا
+
+853
+01:33:11,750 --> 01:33:17,950
+ولاد آدم وحوة وكلنا ممكن نتزوج من بعض وبنخلّط يعني
+
+854
+01:33:17,950 --> 01:33:24,770
+كلنا نفس النوع اللي هو الـ Species اللي بيكون يعني
+
+855
+01:33:24,770 --> 01:33:31,250
+من نفس المجموعة فالـ
+
+856
+01:33:31,250 --> 01:33:40,550
+يعني هنا مرات بدرست ترابط الأمور مع بعض والـ
+
+857
+01:33:41,260 --> 01:33:49,460
+يعني هاي طريقة برضه تانية لدراسة كيف مجمل يعني هنا
+
+858
+01:33:49,460 --> 01:33:55,620
+الفكرة عبارة عن هي دراسة للـ DNA بس الـ DNA الكلي
+
+859
+01:33:55,620 --> 01:34:01,260
+يعني ما احنا هنا بنتكلم على شخص على الـ Gen معين
+
+860
+01:34:01,260 --> 01:34:09,000
+بشكل محدد هنا هذه الدراسة بيستخدموا مثلا هنا 430
+
+861
+01:34:09,000 --> 01:34:18,730
+Markerباستخدام تقنية معينة بشكل معين بحيث إنه هيك
+
+862
+01:34:18,730 --> 01:34:23,410
+شكل الشخص اللي من أصول أفريقية هيك شكل الشخص اللي
+
+863
+01:34:23,410 --> 01:34:30,270
+من أصول أوروبية هيك من الإنسان المخلط وبإمكاني إني
+
+864
+01:34:30,270 --> 01:34:35,890
+من خلالها أطلع شو تأثير ال population هذهما هي
+
+865
+01:34:35,890 --> 01:34:40,770
+أصول البشر اللي فيها أصول أوروبية أو أصول أفريقية
+
+866
+01:34:40,770 --> 01:34:44,930
+أو أصول إسبانية أو أصول صينية أو أصول هندية أو
+
+867
+01:34:44,930 --> 01:34:54,310
+أصول أكتر أنواع مختلفة يعني هذه مجمل القضايا اللي
+
+868
+01:34:54,310 --> 01:35:01,910
+موجودة في محاولة وصف الـ Variation
+
+869
+01:35:03,260 --> 01:35:08,700
+للـGenetic Diseases أو الـGenetics in Population
+
+870
+01:35:08,700 --> 01:35:15,800
+يعني في مجمل population معينة أحنا هنا ما بنتكلم
+
+871
+01:35:15,800 --> 01:35:24,260
+عن شخص واحد كيف وضعه، إنما على إشعار، في أسئلة؟
+
+872
+01:35:24,260 --> 01:35:28,920
+في سؤال من كريمة، دكتور أتفضلي يا كريم، كويس، أه
+
+873
+01:35:30,430 --> 01:35:39,270
+كريم، تفضّل اسأل الدكتور سؤال مباشر إذا حابب هلجيت
+
+874
+01:35:39,270 --> 01:35:43,190
+أنت في الأول قُلت من أحد الافتراضات عشان يعمل هذه
+
+875
+01:35:43,190 --> 01:35:47,110
+الفرضية إنه يكونش في migration أحنا بنفترض إن
+
+876
+01:35:47,110 --> 01:35:51,150
+مافيش migration حصر، إيش جزء من ال migration هذا؟
+
+877
+01:35:51,150 --> 01:35:59,620
+ال migration هو حدد وفيه إله تأثير علىبسموه الـ
+
+878
+01:35:59,620 --> 01:36:04,460
+Founder Effect كويس، ذكرتني فيه كان لازم نحكي عنه
+
+879
+01:36:04,460 --> 01:36:15,300
+الآن لما أنت تيجي عشان تفهم الـ P و الـ Q و الـ QQ
+
+880
+01:36:15,300 --> 01:36:22,860
+و P هاي اللي حطيناها الإفتراضات الأولى مهمة جداً
+
+881
+01:36:22,860 --> 01:36:28,540
+إن الـ Population Study is largeوالـ Matings are
+
+882
+01:36:28,540 --> 01:36:34,580
+random شو يعني random؟ يعني مافيش مثال زي الـ Zero
+
+883
+01:36:34,580 --> 01:36:38,640
+Fitness هذا إنه إذا صار ميوتاشيا معينة ماحدش بتجوز
+
+884
+01:36:38,640 --> 01:36:44,420
+هذا الإنسان فهو يعني ممكن صفة معينة تتخلي هذا
+
+885
+01:36:44,420 --> 01:36:49,440
+الإنسان مش مرغوب ماحدش بده يتجوزها أو حدا يتجوز
+
+886
+01:36:49,440 --> 01:36:56,310
+المصاد هذا فكل هذه الاشتراطات حاجةبتعتمد على إن
+
+887
+01:36:56,310 --> 01:37:01,770
+الـ population كبيرة ومفتوحة طيب تيجي أنت مثلًا
+
+888
+01:37:01,770 --> 01:37:08,110
+على مجموعة موجودة ومستقرة في هذا المكان فجأة مثلًا
+
+889
+01:37:08,110 --> 01:37:12,990
+إحنا في شمال الأردن أو في الأردن يجينا migration
+
+890
+01:37:12,990 --> 01:37:21,030
+مثلًا الله يفق عنهم السوريين ماشي وإحنا مثلًا
+
+891
+01:37:21,030 --> 01:37:27,390
+الأصل إحنا مثلًا مثلًا مليونيجينا ربع مليون سوري
+
+892
+01:37:27,390 --> 01:37:33,670
+فجأة مرة واحدة وأنا أدرس احتمالية الجينات حدوث
+
+893
+01:37:33,670 --> 01:37:40,110
+الهجرة هذه ممكن تغير لنسب الجينات بحيث إن الأرقام
+
+894
+01:37:40,110 --> 01:37:45,770
+اللي عندي قد لا تكون سليمة وأحياناً هذا موضوع مؤثر
+
+895
+01:37:45,770 --> 01:37:50,150
+يعني الـ… الـ population بالذات إذا بيصير فيها
+
+896
+01:37:50,150 --> 01:37:56,830
+isolation يعني مثلاً في أمريكاإذا بتسمع مجموعة
+
+897
+01:37:56,830 --> 01:38:00,490
+اللي بيسموهم الـ Amish أو الـ «مارموند» أو الـ
+
+898
+01:38:00,490 --> 01:38:07,510
+يعني هدولة مجموعات هدولة مثلا في أمريكا صحيح بس
+
+899
+01:38:07,510 --> 01:38:14,130
+هدولة من أصول يعني زي يعني بضربها مثل إذا بتروح
+
+900
+01:38:14,130 --> 01:38:20,350
+على سوريا ولا بلبنان بتلاقي المخيمات للفلسطينيين
+
+901
+01:38:20,350 --> 01:38:27,640
+بقولك المنطقة الفلانيةاللي انتهجروا من صفر المنطقة
+
+902
+01:38:27,640 --> 01:38:31,040
+الأفلانية اللي انتهجروا من الناصرة المنطقة
+
+903
+01:38:31,040 --> 01:38:35,980
+الأفلانية اللي انتهجروا من يعني حتى مثلا لغزة فلما
+
+904
+01:38:35,980 --> 01:38:41,180
+انتقلت نوع من الـ Migration بيغير يعني ممكن إذا
+
+905
+01:38:41,180 --> 01:38:46,120
+صار تزاوج بس في منطقة معينة يعني هدولة اللي بحكي
+
+906
+01:38:46,120 --> 01:38:51,160
+عنهم الـ Mormons أو القامش في أمريكا إذا تدخل على
+
+907
+01:38:51,160 --> 01:38:57,510
+هيك تشوف صورهم بتميزوه يعنيعبارة عن يعني ناس من
+
+908
+01:38:57,510 --> 01:39:03,810
+ألمانيا شبيهين جدا للألمان كشكل وللأن كثقافة
+
+909
+01:39:03,810 --> 01:39:10,710
+وبتزوجوش إلا من بعض وبخلفوا كثير فبتلاقي أنت هنا
+
+910
+01:39:10,710 --> 01:39:14,750
+الـ population هذه أحياناً بعض الـ diseases
+
+911
+01:39:14,750 --> 01:39:19,810
+بتلاقيها نسبتها أعلى بكتير بسبب اللي بيسمونه
+
+912
+01:39:19,810 --> 01:39:24,700
+Founder Effect يعنيإنه اللي بدأ هذه الـ Population
+
+913
+01:39:24,700 --> 01:39:31,420
+يعني مثلًا تتوقع مثلًا الجزيرة سفينة اتحطمت على
+
+914
+01:39:31,420 --> 01:39:38,180
+الجزيرة هذه فيها مثلًا عشرين زلمة ومرة تيجي بعد
+
+915
+01:39:38,180 --> 01:39:42,920
+200 سنة والجزيرة هذه معزولة، شو اللي راح يصير؟
+
+916
+01:39:42,920 --> 01:39:48,840
+بسبب إنه بدأت هذه من مجموعة قليلة وما صارش عليهم
+
+917
+01:39:48,840 --> 01:39:54,730
+هجرةوماتغيرتش، فبتلاقي النسب مختلفة عن غيرها، هذا
+
+918
+01:39:54,730 --> 01:40:02,270
+المقصود وقضية الهجرة من ناحية مؤثرة على نسب الـ P
+
+919
+01:40:02,270 --> 01:40:12,130
+و الـ Q راح تتأثر شو موجودة لأنه هنا … يعني
+
+920
+01:40:12,130 --> 01:40:19,450
+هنا صار حدث معين بطريقة معينة اللي هو أنه بداية ال
+
+921
+01:40:19,450 --> 01:40:25,910
+population هذهكانت عندهم Gen معين، شكل معين، نسبته
+
+922
+01:40:25,910 --> 01:40:31,270
+أكتر واحد، اثنين أو غيرهم مصابين فبالتالي ضالوا
+
+923
+01:40:31,270 --> 01:40:35,750
+ظاهر وبالتالي يعني الـ… الـ… الـFrequency تبعته
+
+924
+01:40:35,750 --> 01:40:39,730
+أعلى بكتير المعادلات اللي بنحكيها على هذه
+
+925
+01:40:39,730 --> 01:40:44,510
+الافتراضات اللي هي أنه الـP و الـQ لما نعتبرها
+
+926
+01:40:44,510 --> 01:40:50,020
+بهذا بس يعني مثلا لما تتكلم نقص أمريكاهي عندي
+
+927
+01:40:50,020 --> 01:40:56,540
+الـWhites أو الـEuropeans أو الـCaucasians وفيه
+
+928
+01:40:56,540 --> 01:41:00,220
+الـBlacks وفيه الـHispanics ودرجة الاختلاف هذه
+
+929
+01:41:00,220 --> 01:41:06,780
+طبعاً راح تتأثر إذا في تزاوج أو مافيش تزاوج وكم
+
+930
+01:41:06,780 --> 01:41:13,180
+نسبة اللي بتزاوجوا من بين الـRaces اللي هي يعني
+
+931
+01:41:13,180 --> 01:41:20,230
+العراق البشريةماشي الصينيين الأفارقة الأوروبيين
+
+932
+01:41:20,230 --> 01:41:24,570
+القوقازيين يعني بدك تاخدها بعين الاعتبار في سؤال
+
+933
+01:41:24,570 --> 01:41:31,270
+واضحط ان شاء الله القضية الله يعفوكم ونشوفكم يوم
+
+934
+01:41:31,270 --> 01:41:34,970
+الأربع ان شاء الله واجهزوا للامتحان الله يعفوكم
+
+935
+01:41:34,970 --> 01:41:37,990
+الله
+
+936
+01:41:37,990 --> 01:41:41,470
+يعفوكم يا دكتور الله يعفوكم أهلا و أهلا و السلام
+
+937
+01:41:41,470 --> 01:41:41,790
+عليكم
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/wEkbdETtaiE_raw.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/wEkbdETtaiE_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..3b6d9b24806f75db9630315a7c57e844dc6a0406
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/wEkbdETtaiE_raw.srt
@@ -0,0 +1,2284 @@
+1
+00:00:00,000 --> 00:00:07,040
+نقطة معينة الآن الصورة
+
+2
+00:00:07,040 --> 00:00:18,180
+هذه صراحة بتعقد يعني بتخربط الواحد وبتلاقي
+
+3
+00:00:18,180 --> 00:00:21,600
+لما
+
+4
+00:00:21,600 --> 00:00:27,640
+تتذكر أي فصل هي موجودةبالنسبة لـ Identify Genetic
+
+5
+00:00:27,640 --> 00:00:34,380
+Basis قدرني الرقم فاصل عشرة أتوقع هيك خلّينا نشوف
+
+6
+00:00:34,380 --> 00:00:40,660
+هنا الآن
+
+7
+00:00:40,660 --> 00:00:44,880
+اللي
+
+8
+00:00:44,880 --> 00:00:49,160
+بنحكي عنه بالنسبة لل .. لأ مش فاصل عشرة
+
+9
+00:00:55,110 --> 00:00:57,930
+على مستوى الوزيارة الوزيارة الوزيارة الوزيارة
+
+10
+00:00:57,930 --> 00:01:00,230
+الوزيارة الوزيارة الوزيارة الوزيارة الوزيارة
+
+11
+00:01:00,230 --> 00:01:02,750
+الوزيارة الوزيارة الوزيارة الوزيارة الوزيارة
+
+12
+00:01:02,750 --> 00:01:04,490
+الوزيارة الوزيارة الوزيارة الوزيارة الوزيارة
+
+13
+00:01:04,490 --> 00:01:10,910
+الوزيارة الوزيارة الوزيارة الوزيارة
+
+14
+00:01:10,910 --> 00:01:14,550
+الوزيارة الوزيارة الوزيارة الوزيارة الوزيارة
+
+15
+00:01:14,550 --> 00:01:16,310
+الوزيارة الوزيارة الوزيارة الوزيارة الوزيارة
+
+16
+00:01:16,310 --> 00:01:20,470
+الوزيارة
+
+17
+00:01:20,960 --> 00:01:32,500
+إنه مطلوب من الواحد يقرأ أبحاث أو يعمل
+
+18
+00:01:32,500 --> 00:01:41,150
+دراسة معينة يفهم المبدأالـ Test اللي هو بيستخدموه
+
+19
+00:01:41,150 --> 00:01:47,910
+يعني هسة مثلا يعني أكبر مثال الآن لو سألت معتز انت
+
+20
+00:01:47,910 --> 00:01:52,630
+بتسمع عن الـ Corona ما Corona هذا و COVID-19 و
+
+21
+00:01:52,630 --> 00:01:59,110
+جائحة أو Pandemic يعني اشتاحت العالم كله، ماشي؟ شو
+
+22
+00:01:59,110 --> 00:02:05,030
+ال tests اللي عندنا؟ اللي هنا؟ مفروض، الآن مفروض
+
+23
+00:02:05,410 --> 00:02:10,430
+الواحد يكون على عبّينة وعلم شو الأشياء اللي تستخدم
+
+24
+00:02:10,430 --> 00:02:13,670
+لما يقولوا «هذا positive، هذا negative» «ليش هذا
+
+25
+00:02:13,670 --> 00:02:17,630
+positive؟ ليش هذا negative؟» بتشكل هذا فشو أنواع
+
+26
+00:02:17,630 --> 00:02:22,390
+الـ «Tests» اللي لنا أنت
+
+27
+00:02:22,390 --> 00:02:28,030
+حكيت كلمة اللي هي الـ «PCR» هم حقيقةً فيه ثلاث
+
+28
+00:02:28,030 --> 00:02:33,110
+أنواع من الفحوصات مش نوع واحدوبدّك تنتبه لما
+
+29
+00:02:33,110 --> 00:02:38,730
+يقولوا إنسان طلع إيجابي أو سلبي حسب شونه الـ Test
+
+30
+00:02:38,730 --> 00:02:44,950
+اللي استخدمه فالآن اللي لو أخدنا مثال الـ Corona
+
+31
+00:02:44,950 --> 00:02:55,010
+الـ Corona بتلاقوا ثواني، أه بتلاقوا الـ Corona
+
+32
+00:02:55,010 --> 00:03:04,310
+إذا بناخدها الـ Corona إبارة عنثلاث أنواع من
+
+33
+00:03:04,310 --> 00:03:10,450
+الفحوصات الـ «كورونا» والفيروس ما هو نوع المادة
+
+34
+00:03:10,450 --> 00:03:14,630
+الورافية تبعته؟
+
+35
+00:03:14,630 --> 00:03:22,270
+الـ RNA الـ RNA بدأ تعطي إيش؟ ما يحاولون استخدامه
+
+36
+00:03:22,270 --> 00:03:27,110
+أحيانًا كلقاح أو يستخدموه في الفحص و لا كده، بتعطي
+
+37
+00:03:27,110 --> 00:03:32,640
+بروتيناللي هو أكثر شيء يعني بيسموه كورونا كورونا
+
+38
+00:03:32,640 --> 00:03:38,560
+يعني التاجي اللي زي التاج يعني عبارة عن التاج على
+
+39
+00:03:38,560 --> 00:03:44,060
+الرأس اللي هي spikes يعني زي الأشياء الحد البروزات
+
+40
+00:03:44,060 --> 00:03:49,440
+الحد على السطح فهذه يعني أنت بتعطي protein ماشي
+
+41
+00:03:49,440 --> 00:03:56,900
+فانت أمام ثلاث مستويات من الفحص أنا ممكن بالـ PCR
+
+42
+00:03:56,900 --> 00:04:06,440
+بفحص على إيشعلى وجود إيش؟ على وجود الـ RNA في
+
+43
+00:04:06,440 --> 00:04:11,600
+العينة يعني بدخل القطنة في أنف المريض أو في بلغم
+
+44
+00:04:11,600 --> 00:04:16,100
+المريض أو على سطح المريض بعمله مسحة ولا كذا والـ
+
+45
+00:04:16,100 --> 00:04:23,420
+PCR أنا بدور على نفس الـ ما اسمه؟ المادة الوراثية
+
+46
+00:04:23,420 --> 00:04:27,320
+تبعت الفيروس على تبع الـ RNA، واضح؟
+
+47
+00:04:29,880 --> 00:04:34,720
+- تمام. – هل هي ممتاز؟ آه، آه، معاك دلوقتي طيب،
+
+48
+00:04:34,720 --> 00:04:42,200
+الخيار الثاني عندي إني باخد برضه مسحة و باخد عينة
+
+49
+00:04:42,200 --> 00:04:45,420
+من المادة
+
+50
+00:04:45,420 --> 00:04:50,540
+أو من البلغم أو من الإشي بدور البروتين تبع الفيروس
+
+51
+00:04:50,540 --> 00:04:55,520
+ففي الحالتين هذولة أنا بدور على وجود نفس الفيروس
+
+52
+00:04:55,520 --> 00:05:02,200
+المادة الوراثية تبعته بالـPCRأو الـ Protein تبعه
+
+53
+00:05:02,200 --> 00:05:10,800
+فأنا بدور عليه شو النوع الثالث من الفحوصات؟ أنا
+
+54
+00:05:10,800 --> 00:05:14,700
+بدور على رد فئل المناعة اللي هم الـ
+
+55
+00:05:14,700 --> 00:05:19,420
+Immunoglobulins فالـ Immunoglobulins فيه الـ IgG
+
+56
+00:05:19,420 --> 00:05:24,420
+والـ IgM الـ IgM بيطلع في الـ acute infection يمكن
+
+57
+00:05:24,420 --> 00:05:29,390
+أن تكون الالتهاب أولهوالـ IGG بيطلع بعدين بيصير
+
+58
+00:05:29,390 --> 00:05:34,810
+اللي هو الذاكرة تبع المناعة وبيكون متأخر وبيظلوا
+
+59
+00:05:34,810 --> 00:05:40,290
+مدة طويلة فلما أنت تقرأ دراسة وحابب أقولك أنا فحصت
+
+60
+00:05:40,290 --> 00:05:45,980
+على الكورونابدّك تفهم منه ك... يعني عشان نفهم شو
+
+61
+00:05:45,980 --> 00:05:51,720
+اللي بحكيه، شو اللي بتكلم عنه، شو النقاط الإيجابية
+
+62
+00:05:51,720 --> 00:05:56,360
+والنقاط السلبية، بدك تشوف الثلاث أشياء هذه، اللي
+
+63
+00:05:56,360 --> 00:06:01,360
+هي أي نوع من الدراسة عملت، هل هي الـPCR؟ الـPCR
+
+64
+00:06:01,360 --> 00:06:07,060
+بتول، الـPCR بده كت وبده أشياء وبدك تكون مافيش إشي
+
+65
+00:06:07,060 --> 00:06:11,640
+من النوع من الـContamination، يعني التلوثيعني لو
+
+66
+00:06:11,640 --> 00:06:17,680
+العينة بطريقة ما اتلوثت بأي احتمال لشيشي قريب أو
+
+67
+00:06:17,680 --> 00:06:22,780
+جزء من شخص آخر الـ PCR تبعه positive بتلاقيه
+
+68
+00:06:22,780 --> 00:06:26,900
+بتطلعلك positive يعني ممكن مثلا جهاز الـ PCR
+
+69
+00:06:26,900 --> 00:06:31,340
+اشتغلوا عليه على مريض طلع إيجابي وظلت نتفت فيروس
+
+70
+00:06:31,340 --> 00:06:36,600
+في الجهاز لما انعقموه ما اتعقمش تماما فلما أجوا
+
+71
+00:06:36,600 --> 00:06:39,740
+درسوا العين الثاني من سبب العين الأقدم صارت
+
+72
+00:06:39,740 --> 00:06:46,130
+positiveففيه ممكن تفحص عن المادة الورافية الـ RNA
+
+73
+00:06:46,130 --> 00:06:50,470
+تبعته بدا تسويلك PCR ممكن تدور على الـ Protein
+
+74
+00:06:50,470 --> 00:06:54,850
+تبعه تستخدموا الـ ELISA مثلا الـ enzyme linked
+
+75
+00:06:54,850 --> 00:06:59,570
+immunosorbent assay فبتدور على الـ Protein وممكن
+
+76
+00:06:59,570 --> 00:07:04,810
+أنت تدور على الـ Antibody ضد الـ Antigen تبع الـ
+
+77
+00:07:04,810 --> 00:07:12,550
+Coronavirus فهم علي؟ فالفكرة إيش هي؟الفكرة إنه بدك
+
+78
+00:07:12,550 --> 00:07:18,990
+تفهم شو القالة اللي معاك تفحص على إيش بالظبط هل
+
+79
+00:07:18,990 --> 00:07:23,130
+أنت بتفحص على المادة
+
+80
+00:07:23,130 --> 00:07:27,510
+الوراثية الـ DNA أو الـ RNA؟ هل بتفحص على مستوى
+
+81
+00:07:27,510 --> 00:07:32,430
+البروتين؟ هل بتفحص إذا كانت DNA؟ ممكن أنا أشوف الـ
+
+82
+00:07:32,430 --> 00:07:38,790
+RNA؟ ماشي الحال، واضحة الفكرة؟تمام يا دكتور، طب
+
+83
+00:07:38,790 --> 00:07:43,710
+وجدت فيها مثلًا أسماء واحد مثلًا جال إنه طلع في
+
+84
+00:07:43,710 --> 00:07:48,970
+الهدى سلبي في الـPCR وفي الـAntibody طلع إيجابي
+
+85
+00:07:48,970 --> 00:07:53,150
+يعني، يكون هدى جيد يعني طبعًا ممكن، يعني أنت
+
+86
+00:07:53,150 --> 00:07:58,010
+الـVirus بيظل عادة إذا منعت الإنسان طبيعي وكذا
+
+87
+00:07:58,010 --> 00:08:04,830
+بيظل مثلًا إيجابي أسبوعين، شهر، بني كثير، بعدين
+
+88
+00:08:04,830 --> 00:08:10,780
+الـVirus يقضي عليهابالمناعة فإذا
+
+89
+00:08:10,780 --> 00:08:16,840
+إنت جيتله، يعني لما نتكلم على دراسة هل مثلا إنت
+
+90
+00:08:16,840 --> 00:08:21,560
+لقيت الإنسان هذا المصاب بالكورونا في أول يوم في
+
+91
+00:08:21,560 --> 00:08:27,120
+الإصابة، في فترة الحضانة، مش إنت لما إحنا عادة أي
+
+92
+00:08:27,120 --> 00:08:33,580
+جرثومة، بالأول نتعرض للجرثومةبتدخل في فترة حضانة
+
+93
+00:08:33,580 --> 00:08:37,680
+Incubation period المريض والإنسان بيكون طبيعي ولا
+
+94
+00:08:37,680 --> 00:08:42,460
+بيشكي من إشي طبيعي مية بالمية بعد أربع، خمس، عشر،
+
+95
+00:08:42,460 --> 00:08:47,920
+عشرين مرات أشهر حسب الفيروس أو البكتيريا أو كذا
+
+96
+00:08:47,920 --> 00:08:53,500
+بيبدأ العراض تظهر عنده فأنت خدته أول الالتهاب، آخر
+
+97
+00:08:53,500 --> 00:08:59,300
+الالتهاب، أنه مرحلة متكلمنا عن الـ IgG والـ IgM
+
+98
+00:08:59,300 --> 00:09:04,080
+هذولة antibodiesبتقولّك التهاب حديث within يعني
+
+99
+00:09:04,080 --> 00:09:10,280
+شهر و لا قديم أكتر من شهر صار له مثلا فاهم عليك؟
+
+100
+00:09:10,280 --> 00:09:15,460
+يعني الـ IgG على الأقل بده أسبوع بما يبدأ يظهر أول
+
+101
+00:09:15,460 --> 00:09:21,320
+مرة بيبين الـ IgM، مابيبينش الـ IgG، واضح؟ طيب يا
+
+102
+00:09:21,320 --> 00:09:24,800
+دكتور، ممكن يصير تداخل مثلا واحد الـfall with إشي
+
+103
+00:09:24,800 --> 00:09:31,650
+ممكن يصير تداخل ويظهر العينة إيجابية؟ شو رأيك؟مش
+
+104
+00:09:31,650 --> 00:09:34,550
+عارف، ممكن فيروسات و… الـCorona Virus مختلف عن
+
+105
+00:09:34,550 --> 00:09:39,170
+الـInfluenza Virus تركيبته وشكله وشكل البروتين
+
+106
+00:09:39,170 --> 00:09:44,030
+تبعه والـRNA Sequence تبقى مختلف لكن نفس الأعراض
+
+107
+00:09:44,030 --> 00:09:52,760
+صحيح، ولمّا واحد يفلوزممكن تكون بكتيريا ممكن تكون
+
+108
+00:09:52,760 --> 00:09:56,100
+أنواع كثيرة من الـ Viruses الـ Rotavirus الـ
+
+109
+00:09:56,100 --> 00:09:59,820
+Echovirus في أنواع كثيرة، مجموعة كبيرة من
+
+110
+00:09:59,820 --> 00:10:04,000
+الفيروسات الـ Epstein-Barr Virus، الـ CMV Virus في
+
+111
+00:10:04,000 --> 00:10:08,220
+مجموعة كبيرة من الفيروسات بتعملك رشحة الرشحة يعني
+
+112
+00:10:08,220 --> 00:10:14,240
+من كلها التهاب لمجاري التنفسي العليا واضح؟فانت
+
+113
+00:10:14,240 --> 00:10:19,880
+يعني الـ Influenza كأعراض مش خاصة فقط بالـ Virus
+
+114
+00:10:19,880 --> 00:10:24,480
+الـ Influenza، لأ بس هو الأكبر مجموعة بتعمل الـ
+
+115
+00:10:24,480 --> 00:10:31,460
+Influenza Virus في الـ Influenza أظن A و B و أشياء
+
+116
+00:10:31,460 --> 00:10:35,280
+زي ذلك كـ Influenza Virus وفي برا Influenza Virus
+
+117
+00:10:35,280 --> 00:10:40,380
+وفيالـ «Rota» والـ «Echo» يعني عدد كبير من
+
+118
+00:10:40,380 --> 00:10:45,500
+الفيروسات أنت مش شغل واحد يعني فكلمة «كورونا» هي
+
+119
+00:10:45,500 --> 00:10:51,530
+مجموعة مختلفةمن الفيروسات وجديدة صارت يعني في كان
+
+120
+00:10:51,530 --> 00:10:56,930
+قبل عشر سنين جائحة قريبة Corona One اللي هو سموها
+
+121
+00:10:56,930 --> 00:11:04,370
+متلازمة المنطقة الشرق الأوسط التنفسية الـMersa مش
+
+122
+00:11:04,370 --> 00:11:10,030
+الـMersa الـMesa اللي هي Middle Eastern يعني ليه
+
+123
+00:11:10,030 --> 00:11:13,870
+برضه من مجموعة الـCorona؟ ماشي، فشو النقطة اللي
+
+124
+00:11:13,870 --> 00:11:18,920
+بدي إياها؟ النقطة اللي بدي إياها أنهأنا لما بدي
+
+125
+00:11:18,920 --> 00:11:25,700
+أقرا عن دراسة، بدي أقرا واحد بيحكي كلام معين لازم
+
+126
+00:11:25,700 --> 00:11:32,180
+أنا أكون فاهمان شو قصده، كيف عملها، شو اللي عمله،
+
+127
+00:11:32,180 --> 00:11:37,420
+يمكن كل اللي عمله غلط بغلط، يمكن، بيصير، فالآن
+
+128
+00:11:37,420 --> 00:11:41,240
+واضح، هي مدخل لللي بنناقشه هلأ
+
+129
+00:11:47,180 --> 00:11:54,280
+فإذاً يعني لما أخذنا مثال الكورونا أنا
+
+130
+00:11:54,280 --> 00:12:00,460
+قصدي فيه إنه على الأقل للآن أنا عندي ثلاث ألواء من
+
+131
+00:12:00,460 --> 00:12:05,340
+الفحوصات للكورونا ممكن أنا بفحص على الـ PCR أنا
+
+132
+00:12:05,340 --> 00:12:09,680
+بفحص على المادة الوراثية ممكن أنا أفحص على
+
+133
+00:12:09,680 --> 00:12:13,820
+البروتين تبعه لأن هدول الأثنتين إحنا بنحكي عن وجود
+
+134
+00:12:13,820 --> 00:12:19,430
+الفيروس ممكن أنا أجي أفحص علىالرد فعلي المناعة ضد
+
+135
+00:12:19,430 --> 00:12:24,810
+الفيروس مرات كثيرة في إتهابات كثيرة ما بنقدر نلقط
+
+136
+00:12:24,810 --> 00:12:31,550
+الفيروس itself صعب لأنه ممكن يعني وانت ماخده من
+
+137
+00:12:31,550 --> 00:12:39,550
+الجسم الفيروس يموت مايظلش ممكن يتحلل يعني مايظلش
+
+138
+00:12:39,550 --> 00:12:43,590
+بس الـ Immunoglobulin بظل مدة أطول فممكن الـ
+
+139
+00:12:43,590 --> 00:12:49,710
+Immunoglobulin أستخدمه عشانألاقى الإثبات إنه اللي
+
+140
+00:12:49,710 --> 00:12:55,410
+صار عند الإنسان هذا الإصابة والاتهاب بالفيروس معين
+
+141
+00:12:55,410 --> 00:13:05,190
+يعني هكذا، تمام؟ هسة الموضوع الـ «سلادين» هذولة،
+
+142
+00:13:05,190 --> 00:13:13,550
+ماشي، خلّينا نشوف شو اللي عملوه، يعني إذا أنتوا
+
+143
+00:13:13,550 --> 00:13:20,140
+شايفوا الـScreen اللي معاكي، صح؟صحيح طيب، شو اللي
+
+144
+00:13:20,140 --> 00:13:27,860
+عملوا هنا؟ منظر لما تتطلع عليه، ماشي، شو اسمه؟
+
+145
+00:13:27,860 --> 00:13:36,060
+هيك، بتتعقد، و بدك، يعني بتكون، شو اسمه؟ هيك،
+
+146
+00:13:36,060 --> 00:13:43,700
+بيصير الواحد كأنه يعني مش فاهمان ومقصورة، هيكبتفكر
+
+147
+00:13:43,700 --> 00:13:49,740
+اللي حقها عبقري ومافيش بعده ومافيش قبله وكذا وكذا،
+
+148
+00:13:49,740 --> 00:13:52,760
+وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا،
+
+149
+00:13:52,760 --> 00:13:54,780
+وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا،
+
+150
+00:13:54,780 --> 00:13:54,920
+وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا،
+
+151
+00:13:54,920 --> 00:13:57,680
+وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا،
+
+152
+00:13:57,680 --> 00:13:58,140
+وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا،
+
+153
+00:13:58,140 --> 00:14:01,780
+وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا،
+
+154
+00:14:01,780 --> 00:14:12,840
+وكذا
+
+155
+00:14:13,450 --> 00:14:18,270
+حكينا أنا ممكن أدور على المادة الوراثية تبعته الـ
+
+156
+00:14:18,270 --> 00:14:23,210
+DNA الـ RNA للـ Corona ممكن على الـ Protein ممكن
+
+157
+00:14:23,210 --> 00:14:27,190
+على المناعب
+
+158
+00:14:27,190 --> 00:14:37,030
+تمام؟ واضح النقطة؟ تمام، تمام النقطة طيب، الآن أنا
+
+159
+00:14:37,030 --> 00:14:46,520
+بإمكاني أفحص على كمية شغل الـ Geneفاهم علي؟ الآن
+
+160
+00:14:46,520 --> 00:14:56,000
+يعني الأصل في الـ إنه أنا في الإنسان، الإنسان DNA
+
+161
+00:14:56,000 --> 00:15:02,900
+مش RNA مش زي الكورونا، بس نفس المبدأ الـ RNA، الـ
+
+162
+00:15:02,900 --> 00:15:08,960
+DNA تبع الإنسان هو الأساس هو اللي فيه الشفرة
+
+163
+00:15:08,960 --> 00:15:17,570
+الوراثية هو اللي بيحدد، تمام؟حكينا إنه في كل خلية
+
+164
+00:15:17,570 --> 00:15:23,530
+الجينات اللي من الـ 25 ألف جين اللي في كل الـ
+
+165
+00:15:23,530 --> 00:15:28,830
+Genome الجينات اللازمة لهاي الخلية حتى تعيش حتى
+
+166
+00:15:28,830 --> 00:15:35,210
+تشتغل حتى تسدي وظيفتها هي اللي بتتم تنشيطها، تمام؟
+
+167
+00:15:35,210 --> 00:15:42,860
+فيمقابل إنه فيه جينات ثانية يتم تثبيتهايعني لازم
+
+168
+00:15:42,860 --> 00:15:47,960
+إشي معدّي معيّن من الجينات هذه تشتغل أكثر في هذه
+
+169
+00:15:47,960 --> 00:15:55,400
+الخلية خصيصًا وبالمقابل الجينات
+
+170
+00:15:55,400 --> 00:16:03,440
+الثانية، مجموعة ثانية من الجينات بتتم تثبيت شغلها
+
+171
+00:16:03,440 --> 00:16:10,060
+من ناحية إنها مش لازمة، النتيجة تبعتها، يعني في
+
+172
+00:16:10,060 --> 00:16:14,280
+هذه الخليةهذا الجين ما له الداعي فبالتالي خلاص
+
+173
+00:16:14,280 --> 00:16:20,440
+مسكر وكذا يعني مثلا الـ Hemoglobin جين اللي حكينا
+
+174
+00:16:20,440 --> 00:16:24,900
+عنه هو انت بحاجته في الـ Red Blood Cells كل خلايا
+
+175
+00:16:24,900 --> 00:16:30,460
+الجسم الثاني مسكر عليه ولا له قيمة خلايا الجينات
+
+176
+00:16:30,460 --> 00:16:37,720
+تبعات الـ Hemoglobin موجودة في الـ B و الـ T
+
+177
+00:16:37,720 --> 00:16:40,420
+-Lymphocytesللـ Immunoglobulin في الـ B
+
+178
+00:16:40,420 --> 00:16:44,640
+-Lymphocytes هي اللي بتتم تشغيلها كل قطعة الـ DNA
+
+179
+00:16:44,640 --> 00:16:48,660
+تبع الـ Immunoglobulin في كل الخلايا التانية
+
+180
+00:16:48,660 --> 00:16:56,940
+مايلها شغل، تمام؟ فالآن، شو عملوا هنا؟ اللي عملوا
+
+181
+00:16:56,940 --> 00:17:06,300
+انه، شو اسمه؟ لقوايعني أنت بدي تكون عندك طريقة
+
+182
+00:17:06,300 --> 00:17:11,560
+اللي بيسموها Idealized Gene Expression Profiling
+
+183
+00:17:11,560 --> 00:17:19,680
+Experiment شو يعني؟ يعني هنا هاي دراسة وبحث
+
+184
+00:17:19,680 --> 00:17:26,360
+افتراضي ما تخدها يعني على إنها هي نتيجة إشي حقيقي
+
+185
+00:17:26,360 --> 00:17:33,480
+عبارة عن مثال افتراضي تمام؟ معايا معتز؟معاك يا
+
+186
+00:17:33,480 --> 00:17:46,060
+دكتور؟ أه، أنا الأصل أنه في الخلية الواحدة الجين،
+
+187
+00:17:46,060 --> 00:17:53,210
+كم جين، كم لسخة منه عادةً أثنتين مثلًا، صح؟وحدة
+
+188
+00:17:53,210 --> 00:17:56,690
+على كرموزوم مثلاً إذا هذا الجين على كرموزوم واحد
+
+189
+00:17:56,690 --> 00:18:01,170
+أنا عندي نسختين من الكرموزوم واحد وبالتالي أنا
+
+190
+00:18:01,170 --> 00:18:07,290
+عندي نسختين من هذا الجين تمام هذا الجين ممكن يكون
+
+191
+00:18:07,290 --> 00:18:17,930
+صامت ولا داعي له وش اسمه وبالتالي ما له شغل تمام
+
+192
+00:18:17,930 --> 00:18:22,840
+في الحالة هذهالـ RNA لهذا الجين شماله كام نسخة راح
+
+193
+00:18:22,840 --> 00:18:32,800
+تكون منها؟ فهمت على سؤالي؟ يعني هما نسختين، يعني
+
+194
+00:18:32,800 --> 00:18:42,290
+هيطلع كمان نسختين و لا كام؟ أنا بحكي الآنالـ «DNA»
+
+195
+00:18:42,290 --> 00:18:48,110
+في الـ «نيوكلياس» والأساس ثابت وكامل لكل شيء
+
+196
+00:18:48,110 --> 00:18:51,910
+الخلايا ممكن تحتاجها طول عمرها، في كل مراحلها، في
+
+197
+00:18:51,910 --> 00:18:57,430
+كل شيء لكن كل خلية بتشغّل حسب اللي بتحتاجه خلية
+
+198
+00:18:57,430 --> 00:19:02,610
+مثلًا Red Blood Cell، ماذا تشغّل؟ «جين
+
+199
+00:19:02,610 --> 00:19:10,440
+الهيموجلومين»، صح؟أه صحيح أه اللي هي بتحتاجه مثلًا
+
+200
+00:19:10,440 --> 00:19:15,020
+الـ Red Blood Cell بتتأثر بالـ Erythropoietin الـ
+
+201
+00:19:15,020 --> 00:19:18,460
+Erythropoietin له Receptor هي لازم تكون عرض الـ
+
+202
+00:19:18,460 --> 00:19:24,200
+Receptor تبعه فالـ Red Blood Cell بحاجة لـ الـ الـ
+
+203
+00:19:24,200 --> 00:19:27,480
+الـ الـ الـ الـ الـ gene تبع الـ Receptor للـ
+
+204
+00:19:27,480 --> 00:19:32,300
+Erythropoietin أن يصير شغال هذا قبل، من أول فاهم
+
+205
+00:19:32,300 --> 00:19:37,810
+عليك كيف؟ كل خلية لهامجموعة جينات هي بحاجتها
+
+206
+00:19:37,810 --> 00:19:43,330
+تشغّلها وبقية الأشياء بتظلها صفر مالهاش شغل،
+
+207
+00:19:43,330 --> 00:19:50,230
+مالهاش داعي، مش كل خلية تنتج، كل الجينات بتعمل
+
+208
+00:19:50,230 --> 00:19:56,050
+بتطلع، كل البروتينات، لأ، كل خلية إلها إشي محدد،
+
+209
+00:19:56,050 --> 00:19:59,690
+واضح هذه النقطة؟
+
+210
+00:19:59,690 --> 00:20:05,030
+‏- واضح، هذا بتفهمني ‏- طيب، الآن، لما أنا آجي
+
+211
+00:20:05,550 --> 00:20:12,690
+نفترض أنا مثلاً لخلية العضلات بدها الأكتين والـ
+
+212
+00:20:12,690 --> 00:20:18,910
+Myosin ويلهم جينات تمام؟ وفي للـ Immunoglobulin
+
+213
+00:20:18,910 --> 00:20:24,330
+جين فيلهم جينات بحاجة الـ B-Lymphocytes إلى إن هي
+
+214
+00:20:24,330 --> 00:20:29,420
+تشغلهموالـ Red blood cells لها الـ Hemoglobin هي
+
+215
+00:20:29,420 --> 00:20:33,860
+الجين اللي بدهيها لأن الـ Hemoglobin في الـ Red
+
+216
+00:20:33,860 --> 00:20:38,400
+blood cells عشان ينقل الدم الـ Oxygen وبدنيا لما
+
+217
+00:20:38,400 --> 00:20:44,820
+أنا آجي أمسك الخلايا هذه وأشوف قداش RNA طالع من
+
+218
+00:20:44,820 --> 00:20:52,700
+الجين فاهم عليك كيف؟ فالآن لما أنا آجي أدرس خليط
+
+219
+00:20:52,700 --> 00:21:00,840
+الدمالـ RNA أو البروتين تبع الـ Hemoglobin قداش
+
+220
+00:21:00,840 --> 00:21:05,200
+بيكون منه فيه؟
+
+221
+00:21:05,200 --> 00:21:10,900
+نسخة واحدة، نسخة واحدة؟ لأ، بسألك، مش الـ DNA، الـ
+
+222
+00:21:10,900 --> 00:21:17,840
+DNA متشابه في الكل، نسخة متطابقة في الكل، كم اشتغل
+
+223
+00:21:17,840 --> 00:21:23,540
+هذا الجين وطلّق الـ RNA اللي راح يعطيني البروتين؟
+
+224
+00:21:25,550 --> 00:21:31,130
+بالنسبة للـHemoglobin Gen في خلية عضلات أو خلية
+
+225
+00:21:31,130 --> 00:21:36,050
+جلد أو خلية White Blood Cells كم بدي يكون منه
+
+226
+00:21:36,050 --> 00:21:41,710
+شغال؟ ما لهوش لازمة، مش هيكون صفر، ما لهوش لازمة
+
+227
+00:21:41,710 --> 00:21:44,730
+في الـRed Blood Cell اللي انت حكيت في الأول في
+
+228
+00:21:44,730 --> 00:21:51,770
+الـRed Blood Cell هتلاقيعشرات، مئات، ألاب من
+
+229
+00:21:51,770 --> 00:21:56,830
+الـRNA وبعدين من البروتين فاهم عليك؟ فهيكون فيه
+
+230
+00:21:56,830 --> 00:22:00,410
+تفاوت فما في باقي الخلية ما لهوش لازمة، مش هيشتغل
+
+231
+00:22:00,410 --> 00:22:06,090
+مش هيشتغل فهنا، شو اللي عملوه الدراسة هذه؟ شو اللي
+
+232
+00:22:06,090 --> 00:22:14,470
+عملت؟ أول شيء، عندهم ثمن أشخاص مثلوها عندهم أربع
+
+233
+00:22:14,470 --> 00:22:22,800
+أشخاص مثلاًعندهم سرطان معين وأخذوا الخلايا
+
+234
+00:22:22,800 --> 00:22:33,480
+السرطانية منهم ماشي وأخذوا
+
+235
+00:22:33,480 --> 00:22:42,020
+أربع أشخاص أو ثمان أشخاص مش خلايا سرطانية سواء من
+
+236
+00:22:42,020 --> 00:22:47,330
+نفس البني آدمين يعني أنت بتاخذالمرجع تبعك لنفس
+
+237
+00:22:47,330 --> 00:22:52,730
+الأشخاص بس خلايا مش سرطانية أو بتاخد إنسان طبيعي،
+
+238
+00:22:52,730 --> 00:22:58,710
+يعني ممكن هاي، ممكن هاي، ماشي الحال؟ الـ Test هنا
+
+239
+00:22:58,710 --> 00:23:08,860
+هو لموضوع قداش الجين اشتغلفاهم عليك كيف؟ قداش هذا
+
+240
+00:23:08,860 --> 00:23:13,260
+الجين شغال؟ أنا لسه هنا ما .. مش أنا بفحص بشكل
+
+241
+00:23:13,260 --> 00:23:19,080
+متخصص زي مثلًا تقولّي والله أخدت أنا panel أو
+
+242
+00:23:19,080 --> 00:23:24,840
+مجموعة هنا بيقولوا دارسين meat gene ماشي؟
+
+243
+00:23:24,840 --> 00:23:29,020
+وبيحاولوا يشوفوا قداش الجين اشتغل فأفرض الـmeat
+
+244
+00:23:29,020 --> 00:23:33,580
+gene في عندك immunoglobulin gene وهي واحد ال
+
+245
+00:23:33,580 --> 00:23:38,060
+hemoglobin gene هي اثنينالكيراتين في الجل مثلًا
+
+246
+00:23:38,060 --> 00:23:42,300
+بروتين الكيراتين في الجل برضه دخلته الأكتين
+
+247
+00:23:42,300 --> 00:23:48,100
+والمايوسين تبعان العضلات برضه أخدتهم فالآن لما أنا
+
+248
+00:23:48,100 --> 00:23:54,640
+آجي، أنا عندي أربع أو خمس جينات كل واحد في محل
+
+249
+00:23:54,640 --> 00:23:59,660
+بيشتغل وفي محل مالوش داعي فما عليك كده، فلما أنا
+
+250
+00:23:59,660 --> 00:24:06,190
+آجيأفحص قداش في اللي عنده سرطان في الخلايا
+
+251
+00:24:06,190 --> 00:24:12,690
+السرطانية قداش كل جين يا إما بيشتغل أكثر من
+
+252
+00:24:12,690 --> 00:24:19,390
+الاعتيادي أو أقل من الاعتيادي فانت هنا يعني هدولة
+
+253
+00:24:19,390 --> 00:24:23,050
+هنا اللي بيحكولك عليك كل واحد من هالخطوط هدولة
+
+254
+00:24:23,050 --> 00:24:27,410
+العينات شايف وين individual sample profile شفتها
+
+255
+00:24:27,410 --> 00:24:35,210
+أول واحدةهنا درسوا عشرة في عشرة ميث جين وبيدوروا
+
+256
+00:24:35,210 --> 00:24:39,490
+على الـ «مسنجر RNA» أو على البروتين الناتج عنه
+
+257
+00:24:39,490 --> 00:24:47,150
+وبيقدروا يشوفوا هل الـ «جين» هذا هو شغال أكثر من
+
+258
+00:24:47,150 --> 00:24:53,110
+الاعتيادي أو أقل من الاعتيادي وهنا الـ… أنت شايف
+
+259
+00:24:53,110 --> 00:24:56,810
+هنا؟ أنا بأشهر لك هنا Individual Sample Profile
+
+260
+00:24:56,810 --> 00:25:03,940
+عظيمهذه أول واحدة اللي
+
+261
+00:25:03,940 --> 00:25:07,840
+كانت بيلاك عليها expression level العزاوية اللي
+
+262
+00:25:07,840 --> 00:25:16,520
+تحت هذه إذا أصفر معناته مقارنة بغيره مقارنة بالـ
+
+263
+00:25:16,520 --> 00:25:21,140
+Normalسواء Normal Individual أو Normal Cell في
+
+264
+00:25:21,140 --> 00:25:28,700
+الإنسان نفسه المعدل التنشيط هذا الـGene هنا زي وزي
+
+265
+00:25:28,700 --> 00:25:37,890
+غير الخلايا الثانية هنا أربع أضعاف الإنتاجوهنا ربع
+
+266
+00:25:37,890 --> 00:25:42,270
+الإنتاج يعني هنا لما نكون إشي أحمر معناته هذه
+
+267
+00:25:42,270 --> 00:25:47,270
+الخلية اللي أنا أخدتها ما صنعت هذا الـ الـ
+
+268
+00:25:47,270 --> 00:25:52,590
+البروتين هذا الجيل في هذه الخلية مش شغال، مالوش
+
+269
+00:25:52,590 --> 00:25:57,770
+قيمة وهنا هذا الإشي اللي شغلته كثير اللي لونه
+
+270
+00:25:57,770 --> 00:26:04,610
+أخضر، تمام؟ معايا للآن؟ ‏- تمام ‏- للآن شو
+
+271
+00:26:04,610 --> 00:26:15,420
+بيعملوا؟هنا لكل إنسان من العشر أو ثمان حالات لميت
+
+272
+00:26:15,420 --> 00:26:23,320
+جين وعرفنا لكل واحد شو عنده، ماشي؟ وهي يعني القصد
+
+273
+00:26:23,320 --> 00:26:28,040
+في الموضوع أنه أنت عندك كمبيوتر وجهاز قوي كثير
+
+274
+00:26:28,040 --> 00:26:32,520
+بقرا الأشياء بسرعة و بقارنها ببعض و بطلّعلك الصورة
+
+275
+00:26:32,520 --> 00:26:38,810
+هذهالآن هذولة ميت جين بس لسه أنا ماعندي تصور في
+
+276
+00:26:38,810 --> 00:26:44,070
+المرض هذا السرطان من هذا النوع أنه جينات اللي
+
+277
+00:26:44,070 --> 00:26:49,110
+مرتبطة بوجود هذا النوع من السرطان إنها أكثر شو
+
+278
+00:26:49,110 --> 00:26:57,290
+بقوم بعمل؟ بعدين بجيب نفس المعلومات اللي هنا الـ
+
+279
+00:26:57,290 --> 00:27:02,270
+Individual Sample Profile اللي طلعتها بالأولبعملها
+
+280
+00:27:02,270 --> 00:27:11,370
+إنه بعيد ترتيبها بهذا الشكل بقص يعني نفس المعلومة
+
+281
+00:27:11,370 --> 00:27:21,490
+يعني إذا تنتبه Sample رقم واحد شوفتها؟ آه بدل
+
+282
+00:27:21,490 --> 00:27:27,730
+ما هي بالمربعات أسكتها طولة خليك معاه قليل شوية
+
+283
+00:27:27,730 --> 00:27:34,240
+Sample رقم واحدفهذه المي اللي هنا اللي بشكل مربع
+
+284
+00:27:34,240 --> 00:27:40,360
+فردناهم بهذا الشكل فأول نتيجة لأول زاوية شو كانت
+
+285
+00:27:40,360 --> 00:27:48,160
+أحمر ولا أخضر ولا أصفر؟ أحمر فهنا أول واحدة حمرة
+
+286
+00:27:48,160 --> 00:27:55,220
+آخر واحدة من هذه الجهة حطينا هنا أصفر وهنا حطينا
+
+287
+00:27:55,220 --> 00:28:00,950
+أخضر غلط يعني بعتبر أنه بضحكوا عليناماشي، بس الأصل
+
+288
+00:28:00,950 --> 00:28:05,070
+أنه يعني فرضوا النتيجة اللي من الـ Individual
+
+289
+00:28:05,070 --> 00:28:12,010
+sample حطوه جنب بعض بهذا الشكل، تمام؟ والأصل ترتيب
+
+290
+00:28:12,010 --> 00:28:17,030
+الجينات، واحد، اتنين، تلاتة، لمية جين، هيك رتبوه
+
+291
+00:28:17,030 --> 00:28:25,990
+بهذا الشكل، ماشي الحال؟ أما في عندك أنت العينات
+
+292
+00:28:25,990 --> 00:28:31,660
+من السرطانوعينات من خلايا طبيعية أو عينات من مرضى
+
+293
+00:28:31,660 --> 00:28:38,280
+السرطان وعينات من بناء آدم طبيعي بالأخير، بالنسبة
+
+294
+00:28:38,280 --> 00:28:41,340
+لتقييم
+
+295
+00:28:41,340 --> 00:28:51,700
+الموضوع أنه أنا بقيم بالنسبة للسرطانات بالنسبة
+
+296
+00:28:51,700 --> 00:29:00,590
+للجينات من واحد لميةما هو الشيء الذي يشغّل هذا
+
+297
+00:29:00,590 --> 00:29:04,390
+الجين من السرطان،
+
+298
+00:29:04,390 --> 00:29:11,810
+وهو اللون الأخضر اللي عنده سرطان معين أنه جين
+
+299
+00:29:11,810 --> 00:29:18,270
+اللون أحمر، يعني ما بيشتغلش فوجود الاختلالات هذه
+
+300
+00:29:18,960 --> 00:29:26,000
+بتأشر لك وين المسبب لهذا السرطان كيف بغير شغل
+
+301
+00:29:26,000 --> 00:29:31,240
+الجينات في هذه العينة وفي هذه الدراسة فهم عليك
+
+302
+00:29:31,240 --> 00:29:40,140
+كيف؟ فهذه دراسة افتراضية إحنا
+
+303
+00:29:40,140 --> 00:29:45,920
+هنا بندرس الـ Gene Expression Profiling من ثمن
+
+304
+00:29:45,920 --> 00:29:52,940
+عيناتو100 جين أنا بدور عليهم فاهم عليك كيف؟ ومع
+
+305
+00:29:52,940 --> 00:29:56,820
+ذلك، ما هي الـ100 جينات؟ وليش بالضبط أنا سويتهم؟
+
+306
+00:29:56,820 --> 00:30:01,420
+وكذا، يعني يمكن صعب، وما بكونوش لسه يعرفوا يعني
+
+307
+00:30:01,420 --> 00:30:08,460
+طريقة تصميم هذه الدراسة بتكون علشان يعني يعني
+
+308
+00:30:08,460 --> 00:30:16,140
+بتكون علشانباستخدام الـ Sequencer أو بيسموها الـ
+
+309
+00:30:16,140 --> 00:30:21,700
+Second Generation Sequencer عبارة عن أجهزة بتقس
+
+310
+00:30:21,700 --> 00:30:26,860
+لها، بتقرا لك الـ DNA بشكل صاروخي، يعني سريع جدا،
+
+311
+00:30:26,860 --> 00:30:32,600
+و عندك معلومات كتيرة و بدك بعدين تحاول تفهمها،
+
+312
+00:30:32,600 --> 00:30:38,580
+فمعناك كيف؟فلما تقول في السرطان اللي فلاني من
+
+313
+00:30:38,580 --> 00:30:41,660
+النوعية اللي فلانية الجين اللي فلاني والجين اللي
+
+314
+00:30:41,660 --> 00:30:48,400
+فلاني يعني هنا ما نقدر نقوله إذا بتلاحظ سرطان من
+
+315
+00:30:48,400 --> 00:30:53,760
+النوع A ويمكن بدل tumor B ممكن تكون الإنسان طبيعي
+
+316
+00:30:53,760 --> 00:31:00,300
+فلما تقوم بتعمل المقارنة واضح إن مثلا الجين رقم
+
+317
+00:31:00,300 --> 00:31:07,230
+واحد اللي عندهم السرطان Aشوف العينات 2 و3 و6 و8،
+
+318
+00:31:07,230 --> 00:31:13,690
+الجين هذا شغال كثير، بينما اللي ماعنده مش سرطان أو
+
+319
+00:31:13,690 --> 00:31:21,910
+سرطان ثاني، هذا الجين كان مش شغال ومثبت كثير، يعني
+
+320
+00:31:21,910 --> 00:31:27,990
+بنرتبهم بهذا الشكل، اللي هناهو أنا شغال كثير ومش
+
+321
+00:31:27,990 --> 00:31:32,790
+شغال وهنا بالعكس هون هاي الجينات هون شغال كثير
+
+322
+00:31:32,790 --> 00:31:38,530
+وهون مش شغالة يعني تقدر تستنتج من الدراسة هذه أنه
+
+323
+00:31:38,530 --> 00:31:43,770
+بتقول مثلا اللي عنده tumor A الجين رقم واحد ورقم
+
+324
+00:31:43,770 --> 00:31:50,490
+خمس وعشرين ورقم مثلا سبعة وعشرين هدولة بكونوا أكثر
+
+325
+00:31:50,490 --> 00:31:55,840
+بكثير من الـ Controlوالجينات الأخرى، رقم كذا ورقم
+
+326
+00:31:55,840 --> 00:32:02,960
+كذا ورقم كذا مثبتة أكثر بكثير من الـ Control «هيك
+
+327
+00:32:02,960 --> 00:32:09,280
+بدك تعيد، بتعيد، بتعيد» فهي يعني صورة بتعقد وإذا
+
+328
+00:32:09,280 --> 00:32:15,200
+ما كان الشرح عليها واضح كثير، ما لها قيمة يعني
+
+329
+00:32:15,200 --> 00:32:22,100
+واحد عنده أرقام وبيعرضها وما لهاش قيمة أو إنه ممكن
+
+330
+00:32:22,100 --> 00:32:22,480
+إذا
+
+331
+00:32:25,760 --> 00:32:29,980
+الارتباط بين هذا النوع من السرطان مع شغل هذا الجين
+
+332
+00:32:29,980 --> 00:32:35,140
+إذا قوي كثير، المفروض يكون مؤشر إنك تروح تدرسه
+
+333
+00:32:35,140 --> 00:32:38,620
+أكثر، اروح أدور شو طب البروتين اللي بتطلع هذا
+
+334
+00:32:38,620 --> 00:32:44,720
+الجين؟ شو دوره؟ ليش بيخليه؟ شو وظيفته؟ هيك بنقدم
+
+335
+00:32:44,720 --> 00:32:48,780
+الطب و بندرس هذه الموضوع أتأمل أني أكون شرحت
+
+336
+00:32:48,780 --> 00:32:56,130
+الصورة هذه، اللي هي أنه يعني بدكيكون أول شيء عندك
+
+337
+00:32:56,130 --> 00:33:00,450
+القالة اللي بتعمل هذا الاشي ويكون العينات أخدتها
+
+338
+00:33:00,450 --> 00:33:08,550
+بشكل سليم وبعدين تحاول تدرس شو العلاقة بين النقاط
+
+339
+00:33:08,550 --> 00:33:13,870
+هذه الطريق
+
+340
+00:33:13,870 --> 00:33:18,010
+اللي سوناه
+
+341
+00:33:18,010 --> 00:33:20,450
+من قبل هو
+
+342
+00:33:23,350 --> 00:33:32,090
+يعني الـ Gene Expression Profiling يعني عن طريق
+
+343
+00:33:32,090 --> 00:33:36,530
+مثلًا الـ Messenger RNA عن طريق يمكن البروتين
+
+344
+00:33:36,530 --> 00:33:41,270
+الناتج بس في الغالب عن طريق الـ Messenger RNA أنا
+
+345
+00:33:41,270 --> 00:33:51,350
+بعمل، شو اسمه؟ بشوف كمية شغل هذا البروتين، هذا الـ
+
+346
+00:33:51,350 --> 00:33:57,310
+Geneهل هو فاعل وشغّال أو خامل ولم يكن له قيمة؟ لم
+
+347
+00:33:57,310 --> 00:34:02,110
+يتم استفادة منه؟ لم يكن له دور في هذه الخلايا؟
+
+348
+00:34:05,770 --> 00:34:10,990
+فالطريقة الأولى ما حددوش عندى بالظبط شو هو الـ
+
+349
+00:34:10,990 --> 00:34:15,230
+«جين إكسبريشن» شو اسمه الـ «جين إكسبريشن» الـ «جين
+
+350
+00:34:15,230 --> 00:34:15,570
+إكسبريشن» الـ «جين إكسبريشن» الـ «جين إكسبريشن»
+
+351
+00:34:15,570 --> 00:34:15,630
+الـ «جين إكسبريشن» الـ «جين إكسبريشن» الـ «جين
+
+352
+00:34:15,630 --> 00:34:15,930
+إكسبريشن» الـ «جين إكسبريشن» الـ «جين إكسبريشن»
+
+353
+00:34:15,930 --> 00:34:19,550
+الـ «جين إكسبريشن» الـ «جين إكسبريشن» الـ «جين
+
+354
+00:34:19,550 --> 00:34:26,850
+إكسبريشن» الـ «جين إكسبريشن» الـ «جين
+
+355
+00:34:26,850 --> 00:34:31,690
+إكسبريشن»
+
+356
+00:34:31,690 --> 00:34:38,970
+الللورقة العلمية اللي هم كاتبينها مفروض يعطوك مرجع
+
+357
+00:34:38,970 --> 00:34:46,870
+بيحدد بالضبط كيف أملوا الفحص هذا، «شو الجينات
+
+358
+00:34:46,870 --> 00:34:53,970
+بالتفصيل؟» بحلوك لمرجع آخر بيشرحوا فيه «شو هذه
+
+359
+00:34:53,970 --> 00:35:02,570
+الأخضر والأصفر والأحمر اللي سووها»بنفس المبدأ بنفس
+
+360
+00:35:02,570 --> 00:35:11,110
+الطريقة ممكن أنا أعمل يعني هنا باستخدام microarray
+
+361
+00:35:11,110 --> 00:35:19,090
+analysis بجيب series of tumors ماشي مثلا نفترض أنا
+
+362
+00:35:19,090 --> 00:35:25,400
+هنا ناس عندهم سلطان الرئة سلطان الرئةطبعاً ممكن
+
+363
+00:35:25,400 --> 00:35:29,980
+يكون مش من الرئة نفسها ممكن من محل ثاني في الجسم،
+
+364
+00:35:29,980 --> 00:35:33,820
+من المعدة، من القولون، طارت على الرئة، بيصير بس
+
+365
+00:35:33,820 --> 00:35:38,240
+ممكن تكون سرطان رئة مثلاً في small cell carcinoma
+
+366
+00:35:38,240 --> 00:35:43,520
+في non-small cell carcinoma في large cell، في
+
+367
+00:35:43,520 --> 00:35:48,120
+squamous cell، في adenocarcinoma كل واحد من هدول
+
+368
+00:35:48,120 --> 00:35:55,920
+نوع من السرطانات من سرطانات الرئتينطيب، أنا مثلاً
+
+369
+00:35:55,920 --> 00:36:01,940
+أخذت ناس عندهم Small Cell Carcinoma مظهرياً
+
+370
+00:36:01,940 --> 00:36:10,440
+لما أنا أخذ العينة بتكون هاي Small Cell Carcinoma،
+
+371
+00:36:10,440 --> 00:36:16,620
+ماشي؟ باللاقي لما نيجي احنا نعالج المرضى هذولة،
+
+372
+00:36:16,620 --> 00:36:23,000
+نتعامل معهمبتلاقي والله في ناس يعني كأن السرطان
+
+373
+00:36:23,000 --> 00:36:29,840
+حميد أكثر، يعني بطيء، بتلاقي مثلًا والله طول، وفي
+
+374
+00:36:29,840 --> 00:36:36,540
+ناس بتلاقي شديد جدًا، بتلاقي السرطان خلال أسابيع
+
+375
+00:36:36,540 --> 00:36:40,640
+أو أشهر قضى على الإنسان، قضى على المريض، ليش هيك
+
+376
+00:36:40,640 --> 00:36:49,000
+اختلفوا؟ فافرض إنه أنامثلًا، عندي مجموعة مثلًا ناس
+
+377
+00:36:49,000 --> 00:36:54,460
+عندهم سرطان «small cell carcinoma» وقدرت أنا أميز
+
+378
+00:36:54,460 --> 00:37:01,540
+مجموعتين ناس السرطان سريق كثير كثير كثير وناس
+
+379
+00:37:01,540 --> 00:37:08,280
+السرطان بطيء فبحاول أفهم ليش الاختلاف في السلوك
+
+380
+00:37:08,280 --> 00:37:16,090
+فهنا أنا أخدت مجموعة سرطاناتوعندي إشي ثاني استطعت
+
+381
+00:37:16,090 --> 00:37:20,830
+من خلاله أقسمهم لمجموعة cluster A و cluster B يعني
+
+382
+00:37:20,830 --> 00:37:26,190
+هدولة والله B اللي هم بطيئين و cluster A سريقين
+
+383
+00:37:26,190 --> 00:37:33,950
+جدا وخبثين مثلا السرطان تبعهمماشي هنا الأحمر هو
+
+384
+00:37:33,950 --> 00:37:40,010
+اللي يعني هاي بيتكلموا على أنه المرضى هدولة ال
+
+385
+00:37:40,010 --> 00:37:48,550
+survival يعني عيشتهم ويعني قداش سرعة السلطان يخدع
+
+386
+00:37:48,550 --> 00:37:53,320
+المريض اللي عنده من النوع الأحمربتلاقي الناس
+
+387
+00:37:53,320 --> 00:37:59,300
+بتوفوا بحيث إنه أنا بالأشهر خلال عشر سنين هو أنا
+
+388
+00:37:59,300 --> 00:38:03,760
+ماضلش أربعين بالمية من الناس بينما اللي عنده من
+
+389
+00:38:03,760 --> 00:38:10,540
+الـCluster B بعد عشر سنين مثلا تسعين بالمية من
+
+390
+00:38:10,540 --> 00:38:17,300
+الناس لسه حياة، ما ماتوا، فإذا عندي أنا يعني
+
+391
+00:38:17,300 --> 00:38:22,850
+مؤشرات بهذه الطريقةوبعدين بعمل microarray analysis
+
+392
+00:38:22,850 --> 00:38:32,790
+هذه أسلوب الـ «microarray» إنك أنت، شو اسمه؟ بتشوف
+
+393
+00:38:32,790 --> 00:38:43,730
+يعني اللي هو وجود gene بشكل معين بـ mutation معينة
+
+394
+00:38:43,730 --> 00:38:48,930
+أو بـ sequence معينة، درجة وجودهوبتشوف الأخضر
+
+395
+00:38:48,930 --> 00:38:55,430
+والأحمر الأخضر إنه موجود بدرجة أكبر والأحمر موجود
+
+396
+00:38:55,430 --> 00:39:03,610
+بدرجة أقل فأنا هنا بصير أقول والله مجموعة الجينات
+
+397
+00:39:03,610 --> 00:39:08,090
+هذه اللي عندهيا بالشكل هذا لو من أول يوم بعدين
+
+398
+00:39:08,090 --> 00:39:12,870
+يعني بعد ما تطلع النتيجة هذه ويصير هذا الـ Test
+
+399
+00:39:12,870 --> 00:39:20,000
+أنا ممكن أعمله كل ما تجيني حاليمثلًا، سرطان Small
+
+400
+00:39:20,000 --> 00:39:25,020
+Cell Carcinoma تبع الرئتين باجي بعملهم الفحص هذا
+
+401
+00:39:25,020 --> 00:39:29,520
+وبشوف شكل الإنسان هذا زي الـCluster A و لا
+
+402
+00:39:29,520 --> 00:39:34,040
+الـCluster B والله طلع زي الـCluster B، وهو هذا
+
+403
+00:39:34,040 --> 00:39:41,240
+الإنسان إن شاء الله راح يكون التقدم للسرطان بطيء
+
+404
+00:39:41,570 --> 00:39:46,690
+ويمكن مافيش داعي أعالجه وماشدش عليه كثير واتركه
+
+405
+00:39:46,690 --> 00:39:51,130
+بينما بشوف واحد الـ Cluster A لأ بقول هذا إنسان
+
+406
+00:39:51,130 --> 00:39:57,270
+راح يكون مرضه شديد ولازم أدخل بقوة شديدة لازم
+
+407
+00:39:57,270 --> 00:40:01,190
+أعطيه كيماوي لازم أعطيه شعار لازم أعمله عمليات
+
+408
+00:40:01,190 --> 00:40:07,290
+لازم أسوي له كده بتغير سلوكي كطبيب تجاه المريض حسب
+
+409
+00:40:07,290 --> 00:40:16,200
+شكلالـ Microarray Analysis وهذا كله بعد ما يعني
+
+410
+00:40:16,200 --> 00:40:21,480
+أنا اتوصلت للنتيجة هذه من خلال الدراسة هذه أظن
+
+411
+00:40:21,480 --> 00:40:28,240
+أتمن أنه واضح يا معتز فيها إشي هاتف بمعرفة كيف هي
+
+412
+00:40:28,240 --> 00:40:36,780
+ترتيبها وهنا يعني يعني الـ الـ النقطتين، الفلاف
+
+413
+00:40:36,780 --> 00:40:42,710
+اللي أناتركز عليهم وتنتبه عليهم في هذا الوضع أنت
+
+414
+00:40:42,710 --> 00:40:52,650
+هنا يعني أول شي بالنسبة للنقطة هذه أنه أنا أول شي
+
+415
+00:40:52,650 --> 00:40:57,350
+عندي سرطان مثلا واستطعت منه أن ألاقي أن فيه
+
+416
+00:40:57,350 --> 00:41:03,030
+مجموعتين واحد سلوكه حميد واحد سلوكه خبيث واستطعت
+
+417
+00:41:03,030 --> 00:41:07,610
+من خلالالتقسيم المجموعتين هذه إن أدرس الـ DNA
+
+418
+00:41:07,610 --> 00:41:12,570
+تبعهم باستخدام الـ Microarray Analysis لإيش معين
+
+419
+00:41:12,570 --> 00:41:18,030
+لقيت في أشياء تشتغل أكثر وفي أشياء ما بتشتغلش
+
+420
+00:41:18,030 --> 00:41:25,270
+فاللي عنده شكل معينزي الـ Cluster A بهذا الشكل هذا
+
+421
+00:41:25,270 --> 00:41:30,210
+الإنسان راح يكون مستقبله أسود ونتيجته صعبة راح
+
+422
+00:41:30,210 --> 00:41:34,790
+تكون الـ Cluster B لأ راح يكون هذا Benign وحميد
+
+423
+00:41:34,790 --> 00:41:41,370
+وأنا بإمكاني أصبر وأستنى فربطوا هذا الموضوع بالـ
+
+424
+00:41:41,370 --> 00:41:49,520
+Survivalوبقاء الحالات لمدة متابعوهم سنين طويلة عشر
+
+425
+00:41:49,520 --> 00:41:54,080
+سنين أو أحداشر سنة هنا ولقوا هذه النتيجة فبالتالي
+
+426
+00:41:54,080 --> 00:41:59,380
+هذه الدراسة تقدر تساعدني في المستقبل كيف أتعامل مع
+
+427
+00:41:59,380 --> 00:42:05,360
+المرضى هذول من هذا النوع فهذه الأشياء مواضيع معقدة
+
+428
+00:42:05,360 --> 00:42:11,240
+هل هي ممكنة في كل مكان في العالم وسهل الواحد
+
+429
+00:42:11,240 --> 00:42:16,460
+يعملها؟ لأوبعدين يعني حتى لو قلت مثلا والله لقوا
+
+430
+00:42:16,460 --> 00:42:21,760
+هذه النتيجة في أمريكا ماشي تيجي تقول مثلا والله في
+
+431
+00:42:21,760 --> 00:42:26,060
+الأردن أنا بدي أجعل أكرر نفس التجربة واستفيد من
+
+432
+00:42:26,060 --> 00:42:31,080
+هذا الـ من هذه النتيجة تماما لمرضاي يمكن ما ينطبق
+
+433
+00:42:31,080 --> 00:42:38,430
+عليهم وما تفيدكماشي، إن شاء الله أنه يضحك، بس يعني
+
+434
+00:42:38,430 --> 00:42:44,750
+هذه أشياء معقدة وبدك تقراها شويه شويه حتى تستوعب
+
+435
+00:42:44,750 --> 00:42:52,130
+شو اللي بكتبوا عنه ومافيش زي إنك أنت تجربها بإيدك
+
+436
+00:42:52,130 --> 00:43:00,100
+أو تقرا دراسة عنهاوتغوص في آلية
+
+437
+00:43:00,100 --> 00:43:03,880
+عمل الدراسة الـ Methodology شو بالضبط سووا، كيف
+
+438
+00:43:03,880 --> 00:43:08,360
+عملوها، شو اشتراطاتهم، شو كذا مرات كثير هذه
+
+439
+00:43:08,360 --> 00:43:14,440
+الأشياء بتكون مالهاش قيمة يعني واحد عنده مصاري
+
+440
+00:43:14,440 --> 00:43:19,220
+وعمل تجربة وبده يطلع نتيجة فالعالم بتفيد، بتفدش،
+
+441
+00:43:19,220 --> 00:43:23,380
+بيقدروا الناس اللي بعده يطلعوا نفس النتيجة ولا لا
+
+442
+00:43:25,870 --> 00:43:33,070
+ماشي، في أسئلة، في إشي محدد مش واضح يا معتز أو يا
+
+443
+00:43:33,070 --> 00:43:40,150
+كريم أو أي حد أو .. ممكن تحل سؤال الـ E-World
+
+444
+00:43:40,150 --> 00:43:48,890
+تختار، سؤال من ملف الـ E-World آه، أي سؤال؟ الرقم
+
+445
+00:43:48,890 --> 00:43:59,370
+28اللي هو يُاسم ليه «Kaplan» ولا «Genetics»؟ لأ
+
+446
+00:43:59,370 --> 00:44:08,930
+ليش «Kaplan» طيب الـ «Genetics» سؤال رقم 28 الأول
+
+447
+00:44:08,930 --> 00:44:16,270
+الأوائل ولا الفواني؟ الـ «Log» الأول 28 الـ «Log»
+
+448
+00:44:16,270 --> 00:44:19,070
+الأول طيب، هاي 26
+
+449
+00:44:24,760 --> 00:44:38,020
+27 هاي 28 طيب خلّيني أعمل share هاي
+
+450
+00:44:38,020 --> 00:44:45,620
+new share تقدر
+
+451
+00:44:45,620 --> 00:44:51,080
+تقرأ السؤال يا كريم أه
+
+452
+00:44:51,080 --> 00:44:53,360
+بقرأ بجد طيب يلّا
+
+453
+00:44:59,290 --> 00:45:03,330
+أمرأة عمرها 19 عامة كانت تتعامل مع مخاطرات
+
+454
+00:45:03,330 --> 00:45:09,990
+تونيكية. في السنوات السابقة، كانت أيضًا تتعامل مع
+
+455
+00:45:09,990 --> 00:45:14,410
+مخاطرات إيراكية في أسطولها وعينها، وكذلك بخاطرات
+
+456
+00:45:14,410 --> 00:45:19,750
+عضوية. الفتاة كانت لديها عائلات مختلفة من الخارج،
+
+457
+00:45:19,750 --> 00:45:24,830
+مع إشعارات مشابهة، ومحاولة التجارب تتعامل معها،
+
+458
+00:45:24,830 --> 00:45:28,210
+وكانت تتعامل معها في الجزء الأسفل وفي البوابة
+
+459
+00:45:28,210 --> 00:45:34,280
+المساعدة.Skeletal muscle biopsy shows رجد Red
+
+460
+00:45:34,280 --> 00:45:37,380
+appearing muscle fibers.Further analysis reveals
+
+461
+00:45:37,380 --> 00:45:39,660
+that the patient's symptoms are due to mainly
+
+462
+00:45:39,660 --> 00:45:44,220
+extra nuclear DNA.Which of the following degree is
+
+463
+00:45:44,220 --> 00:45:47,980
+most likely to represent this patient's family
+
+464
+00:45:47,980 --> 00:45:51,380
+history؟طيب،
+
+465
+00:45:51,380 --> 00:45:58,420
+أسا، شوف، خلّينا نحاول يعني مرات كتير لأشياء زي
+
+466
+00:45:58,420 --> 00:46:05,700
+هيكأنا يمكن من حالي مش شايف الـD بشكل واضح، ماشي
+
+467
+00:46:05,700 --> 00:46:09,540
+في
+
+468
+00:46:09,540 --> 00:46:14,340
+الصورة التانية موجود الـD؟ آه، بنزل عليها بعد
+
+469
+00:46:14,340 --> 00:46:18,460
+شوية، بس خلّينا نشوف، بس شو اللي عرفناه من هذه
+
+470
+00:46:18,460 --> 00:46:25,620
+القصة؟ أول شيء، يعني أنا حكيت من قبل إنه تفاصيل
+
+471
+00:46:25,620 --> 00:46:32,740
+المادة العلميةيعني كمرض وشو اسم المرض هذا، يعني هي
+
+472
+00:46:32,740 --> 00:46:40,640
+عندها خلل في الأعصاب، ماشي، عندها نوبات صراع، يعني
+
+473
+00:46:40,640 --> 00:46:43,430
+tonic-clonic seizureاللي هم يعني
+
+474
+00:46:43,430 --> 00:47:05,110
+الـ………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………
+
+475
+00:47:12,010 --> 00:47:19,230
+وعندها بيصير الإصابة
+
+476
+00:47:19,230 --> 00:47:27,410
+تبعتها مش بس عصبية حركية لأ عصبية حسية فـ Decrease
+
+477
+00:47:27,410 --> 00:47:33,530
+sensation ماشي والمأثرة غير الـ Muscle weakness
+
+478
+00:47:33,530 --> 00:47:39,570
+أنه لما تمشي الإنسان زي لما يكون مثلًاإذا بتشوف
+
+479
+00:47:39,570 --> 00:47:43,890
+واحد سكران، واحد عنده بعث على العضلات، بيكون مفحج
+
+480
+00:47:43,890 --> 00:47:49,110
+رجليه كتير، بيحاول أنه عشان يحفظ توازنه، بيكون
+
+481
+00:47:49,110 --> 00:47:56,550
+إجراءه واسعات فلقينا إنه في عندها muscle weakness
+
+482
+00:47:56,550 --> 00:48:02,130
+وأخدوا من الـMuscle Biopsy، لكوا في عندها مشكلة،
+
+483
+00:48:02,130 --> 00:48:10,950
+ماشيولمّا سوّينا لها الـ… لما
+
+484
+00:48:10,950 --> 00:48:15,370
+سوّينا لها الـMuscle Biopsy، ماشي أو آسف، لما
+
+485
+00:48:15,370 --> 00:48:20,310
+سوّينا لها الـGenetic الدراسة، وين المشكلة كانت يا
+
+486
+00:48:20,310 --> 00:48:23,330
+كريم؟
+
+487
+00:48:23,330 --> 00:48:27,350
+عشان
+
+488
+00:48:27,350 --> 00:48:31,810
+سؤال بس، عشان جدًالمّا كتبوا لك في السؤال في
+
+489
+00:48:31,810 --> 00:48:35,470
+الـSTEM «معلومات أخرى يظهر أن الشيء اللي يحدث في
+
+490
+00:48:35,470 --> 00:48:35,870
+الشيء اللي يحدث في الشيء اللي يحدث في الشيء اللي
+
+491
+00:48:35,870 --> 00:48:36,350
+يحدث في الشيء اللي يحدث في الشيء اللي يحدث في
+
+492
+00:48:36,350 --> 00:48:39,230
+الشيء اللي يحدث في الشيء اللي يحدث في الشيء اللي
+
+493
+00:48:39,230 --> 00:48:39,930
+يحدث في الشيء اللي يحدث في الشيء اللي يحدث في
+
+494
+00:48:39,930 --> 00:48:40,150
+الشيء اللي يحدث في الشيء اللي يحدث في الشيء اللي
+
+495
+00:48:40,150 --> 00:48:40,790
+يحدث في الشيء اللي يحدث في الشيء اللي يحدث في
+
+496
+00:48:40,790 --> 00:48:41,330
+الشيء اللي يحدث في الشيء اللي يحدث في الشيء اللي
+
+497
+00:48:41,330 --> 00:48:41,330
+يحدث في الشيء اللي يحدث في الشيء اللي يحدث في
+
+498
+00:48:41,330 --> 00:48:41,330
+الشيء
+
+499
+00:48:56,860 --> 00:49:03,600
+فهي مثال على «Mitochondrial Disease» ماشي، شو الـ
+
+500
+00:49:03,600 --> 00:49:07,160
+Characteristics بـ degree تبعت الـ «Mitochondrial
+
+501
+00:49:07,160 --> 00:49:11,900
+Disease»؟ الـ «Mitochondrial» ينتقل إلى معلوم
+
+502
+00:49:11,900 --> 00:49:16,600
+لأبناء فقط، بس ورث الـ Female لـ الـ «G» اللي
+
+503
+00:49:16,600 --> 00:49:21,860
+وراها أكثر من هيك، بأثر على ال «Males» ولا الـ
+
+504
+00:49:21,860 --> 00:49:26,210
+«Females»؟بتصل على اتنين، ولكن ما بنتقل من جيل
+
+505
+00:49:26,210 --> 00:49:28,370
+لجيل إلا من الأم، بس الأم اللي بتولّي ثمانية
+
+506
+00:49:28,370 --> 00:49:34,950
+كندرية الـDNA طيب، فإنتي هسة الـA، بنفع ولا بنفعش؟
+
+507
+00:49:34,950 --> 00:49:39,710
+الـA لأ أكيد، لإنه في على الشمال الأب موارثه لإبنه
+
+508
+00:49:39,710 --> 00:49:46,700
+آه، الأب ما بيصير يعني إنسان أب يكون هو المصابغلط
+
+509
+00:49:46,700 --> 00:49:50,220
+إنه يعطي .. بس على أقل إنه males و females
+
+510
+00:49:50,220 --> 00:49:54,380
+affected okay it goes with it يعني تمشي معاهم، بس
+
+511
+00:49:54,380 --> 00:50:00,860
+بما إنه الأب أعطى ولاده، هذا مش هو ال issue الصحيح
+
+512
+00:50:00,860 --> 00:50:05,880
+الـB صح ولا مش صح؟ الـB is autosomal recessive،
+
+513
+00:50:05,880 --> 00:50:11,360
+فبرضه بره نعم الـB is autosomal recessive، فبرضه
+
+514
+00:50:11,360 --> 00:50:13,660
+بره أه he skipped generation لإنه في skip
+
+515
+00:50:13,660 --> 00:50:19,500
+generation، ما بزبطالـ C برضه فيه مشكلة الأب أعطى
+
+516
+00:50:19,500 --> 00:50:26,200
+بناته ما بيثبت ماشي أشوف الـ D و أنا ننزل تحت الـ
+
+517
+00:50:26,200 --> 00:50:34,500
+D الأم أعطت أولادها و بناتها ماعطتهمش ما بيصير
+
+518
+00:50:34,500 --> 00:50:44,080
+يعني و الأم هي الـ affected الـ E شو رأيك فيه الجد
+
+519
+00:50:44,080 --> 00:50:52,500
+مفاعلأعطت ولدها وبناتها كلها ولدتك برضه وعطيتها؟
+
+520
+00:50:52,500 --> 00:50:57,680
+أنا ماعطاش إشي، بينما البنات هم اللي بعطيه وغانا
+
+521
+00:50:57,680 --> 00:51:05,320
+يعني أقرب إشي لهم شو أنه الحل E فخليني نشوف كتبنا
+
+522
+00:51:05,320 --> 00:51:12,710
+الإجابة الـE، بس أنت يعني الفكرةبدّك تقرأ سم
+
+523
+00:51:12,710 --> 00:51:18,330
+السؤال شويه شويه براواقة وتحاول تفهم الأشياء اللي
+
+524
+00:51:18,330 --> 00:51:27,090
+معطينا فيها لو تيجي تنتبه للسؤال مرة ثانية الوصف
+
+525
+00:51:27,090 --> 00:51:33,060
+الأول كله ملوش قيمةيعني بيخربطوا الواحد إنه
+
+526
+00:51:33,060 --> 00:51:36,000
+«Tonic» «Lonic» وكان عنده كده وكان عنده كده
+
+527
+00:51:36,000 --> 00:51:40,120
+وماعندهاش كده يعني ما كانتش هي الإشي المهم هذا الـ
+
+528
+00:51:40,120 --> 00:51:45,820
+«Distractor» يعني هذا إشي بيضيع أما لما تقرا تشوف
+
+529
+00:51:45,820 --> 00:51:50,420
+إنه مثلا أنا المطلوب مني أشوف شو الـ «Type of
+
+530
+00:51:50,420 --> 00:51:56,080
+Inheritance» طيب الـ «Males» ولا «Females»
+
+531
+00:51:56,080 --> 00:52:00,790
+affected هاي مهم كتير، هاي واحدةإذا فيه هو أنا
+
+532
+00:52:00,790 --> 00:52:05,910
+حاطط لإيش تاني هو معطيك إنه extra nuclear DNA يعني
+
+533
+00:52:05,910 --> 00:52:09,150
+بدي يكون mitochondrial inheritance هيك بده تكون
+
+534
+00:52:09,150 --> 00:52:12,450
+النتيجة، فبروح بدور أيه ال mitochondrial؟ و هذا
+
+535
+00:52:12,450 --> 00:52:18,870
+سؤال بعتبره سهل، أنه هاي 84% يعني من كل ثمانية
+
+536
+00:52:18,870 --> 00:52:26,330
+سبعة جاوبوسة، ماشي؟ هيك بدك تمشي بالـ «هيو دكتور»؟
+
+537
+00:52:26,330 --> 00:52:26,690
+آه
+
+538
+00:52:29,890 --> 00:52:36,610
+دكتور أحمد أنا مضطر الآن في عندي كمان شغل بعد شوية
+
+539
+00:52:36,610 --> 00:52:42,170
+يوم الأربع الأربع بيكون امتحان الـ Quiz الأخير
+
+540
+00:52:42,170 --> 00:52:47,050
+شايف عليه؟ ماعليهوش علامة بس يعني عشان تدريب أو
+
+541
+00:52:47,050 --> 00:52:52,590
+بنشوف كيف بنتعامل معاه وبعد ال .. يعني مثلا نقول
+
+542
+00:52:52,590 --> 00:52:56,590
+يوم الإثنان القادم بتحبوا نقعد مرة تانية؟ إذا حد
+
+543
+00:52:56,590 --> 00:53:01,540
+عنده أسئلة زي هذا؟إذا ما بدناش نقعد على الـ Zoom
+
+544
+00:53:01,540 --> 00:53:06,220
+فيه الـ «جروب» تبع الـ Medical Genetics أتأمل أنه
+
+545
+00:53:06,220 --> 00:53:10,400
+على الـ WhatsApp بنقدر نستفيد منها يعني اللي بيحط،
+
+546
+00:53:10,400 --> 00:53:17,420
+ما حد يتواصل معايا درجاءً من طالب شخصي يعني واحد
+
+547
+00:53:17,420 --> 00:53:21,280
+دواحد اللي بيده أي سؤال من خلال الـ «جروب» الـ
+
+548
+00:53:21,280 --> 00:53:25,720
+Medical Genetics بيحط السؤال للجميع وأنا بجاوب
+
+549
+00:53:25,720 --> 00:53:27,580
+للجميع، ماشي الحال؟
+
+550
+00:53:33,180 --> 00:53:41,520
+الله يوفقكم و الله يحفظكم وإن شاء الله أكون قدرت
+
+551
+00:53:41,520 --> 00:53:47,960
+أني يعني أوصل أفكار ماشي يا كريم ويا معتز والشباب
+
+552
+00:53:47,960 --> 00:53:52,980
+والدكتورات الكل يعني يا عزيزي عفوا يا دكتور الله
+
+553
+00:53:52,980 --> 00:53:58,600
+يبارك فيك الله يحييكمأي واحد عنده أي سؤال يفضطه
+
+554
+00:53:58,600 --> 00:54:08,200
+على group المساقل للكل ويحاول يعني يكون عنده يعني
+
+555
+00:54:08,200 --> 00:54:13,160
+يودّينا شو هو السؤال بشكل واضح ممكن واحد يتكلم
+
+556
+00:54:13,160 --> 00:54:20,160
+يعني دكتور بس أكد أكد لكريم على علامةحكيت للدكتور
+
+557
+00:54:20,160 --> 00:54:25,080
+احفظه خلاص اللي موجودين كلهم كانوا يحضروا كتير
+
+558
+00:54:25,080 --> 00:54:30,520
+يعني غير علامة كريم الموجودين كلهم انهم علامة
+
+559
+00:54:30,520 --> 00:54:34,220
+لأنهم كانوا من ضمن يعني الناس الملتزمين دايما مافي
+
+560
+00:54:34,220 --> 00:54:41,060
+مشكلةما في مشكلة، الدكتور أحمد يعني أنا المشاركة
+
+561
+00:54:41,060 --> 00:54:45,060
+يعني صراحة هو صحيح، إلها دور وإلها نشاط، أه أنا
+
+562
+00:54:45,060 --> 00:54:51,400
+يعني مع أنه يعني نحط لهم bonus للي حضروا ولي حضروا
+
+563
+00:54:51,400 --> 00:54:56,260
+المرة هذه بالتالت، الله يوفقهم وإن شاء الله بيبقوا
+
+564
+00:54:56,260 --> 00:55:01,380
+على تواصلفإن شاء الله يوم الأربعة، يعني يوم
+
+565
+00:55:01,380 --> 00:55:08,160
+الثلاثة بديلك الأسئلة يا دكتور أحمد وهذه الأمر أنا
+
+566
+00:55:08,160 --> 00:55:15,420
+موافق عليه ومش إن شاء الله شو اسمه؟ هتكون الأسئلة
+
+567
+00:55:15,420 --> 00:55:19,720
+عادية ولا فيها U word يا دكتور؟ نعم هتكون الأسئلة
+
+568
+00:55:19,720 --> 00:55:24,340
+عادية ولا فيها U word؟ وإيش يعني؟ شو فيها؟ أسامة
+
+569
+00:55:24,340 --> 00:55:31,380
+بلكم مش تسأله هيكماشي شو ما يجيلك حل ماشي الله
+
+570
+00:55:31,380 --> 00:55:38,860
+يسهل الله يحييكم يلا السلام عليكم علينا علينا يلا
+
+571
+00:55:38,860 --> 00:55:39,700
+السلام عليكم
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/w_288b1_4WQ.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/w_288b1_4WQ.srt
new file mode 100644
index 0000000000000000000000000000000000000000..03e8f1fa344714b1b61c145182bec90d3aaadfe1
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/w_288b1_4WQ.srt
@@ -0,0 +1,2403 @@
+1
+00:00:00,000 --> 00:00:05,920
+الجميع من دخل معنا في المحاضرة ووفقكم الله
+
+2
+00:00:05,920 --> 00:00:09,040
+بالنسبة
+
+3
+00:00:09,040 --> 00:00:13,020
+إن أول المحاضرة دائماً،  لمن في حد عنده سؤال عن
+
+4
+00:00:13,020 --> 00:00:19,780
+مواضيع سابقة، مواضيع الامتحان، ومش امتحان، شو
+
+5
+00:00:19,780 --> 00:00:25,600
+بنسأله المرات الجاية عند الدكتور أحمد للشباب
+
+6
+00:00:25,600 --> 00:00:30,590
+والدكتورات اللي موجودين، إذا حد عنده أسئلة في
+
+7
+00:00:30,590 --> 00:00:35,390
+الوراثة، إذا
+
+8
+00:00:35,390 --> 00:00:40,190
+في حد عنده سؤال، ممكن نبدأ نشرح. يعني دائماً الأسئلة
+
+9
+00:00:40,190 --> 00:00:47,190
+جيدة، وبيشرح الواحد فيها نقطة بشكل مُفيد عند
+
+10
+00:00:47,190 --> 00:00:52,250
+الواحد يوم
+
+11
+00:00:57,360 --> 00:01:04,440
+فاحنا نتكلم إن شاء الله عن موضوع آخر، ماشي،
+
+12
+00:01:04,440 --> 00:01:12,400
+كأنه فيه سؤال كرمل؟
+
+13
+00:01:12,400 --> 00:01:16,100
+طيب
+
+14
+00:01:16,100 --> 00:01:22,900
+بالنسبة لقضية الـ Human أو الـ Developmental
+
+15
+00:01:22,900 --> 00:01:24,740
+Genetics، انبعاث التفكير
+
+16
+00:01:28,040 --> 00:01:33,340
+يعني هذا موضوع يعني
+
+17
+00:01:33,340 --> 00:01:42,420
+شغل العلماء، وهناك يعني جوانب
+
+18
+00:01:42,420 --> 00:01:49,900
+في تطور الإنسان وخلق الإنسان، وبعد ذلك حدوث
+
+19
+00:01:49,900 --> 00:02:00,190
+اختلالات معينة، بشكل يعني، بانقسام غريب، يجذب الانتباه
+
+20
+00:02:00,190 --> 00:02:09,330
+وهذه يعني يتم دراستها في عالمة مصرية في الخمسينات
+
+21
+00:02:09,330 --> 00:02:15,790
+والستينات، من أقوى من قام بدراسة الاختلالات
+
+22
+00:02:15,790 --> 00:02:24,690
+التطورية في ذات اليدين والرجلين، وطريقة الاختلال
+
+23
+00:02:24,690 --> 00:02:32,110
+أنا يعني، إذا بدي شيء من هالصورة اللي قدامنا، بدي
+
+24
+00:02:32,110 --> 00:02:32,430
+اسم
+
+25
+00:02:32,430 --> 00:02:48,890
+الـ
+
+26
+00:02:49,710 --> 00:02:56,890
+تخيل، أو متابعة
+
+27
+00:02:56,890 --> 00:03:02,230
+لقضية ما يحصل، أو ما هو الخلل هنا، أو ما يسميها
+
+28
+00:03:02,230 --> 00:03:07,490
+فالطفل هذا اللي عنده سبع أصابع، هذا اسمه
+
+29
+00:03:07,490 --> 00:03:13,770
+polydactyly، axial polydactyly، poly يعني أكثر،
+
+30
+00:03:13,770 --> 00:03:22,960
+dactyly اللي هي يعني قضية الأصابع، ماشي، و"severe
+
+31
+00:03:22,960 --> 00:03:28,960
+cutaneous syndectomy"، "سن" يعني مجموع مع بعضه
+
+32
+00:03:28,960 --> 00:03:32,200
+فالأصابع
+
+33
+00:03:32,200 --> 00:03:40,860
+بشكل جلدي، مجموعات على بعض، وفي اختلال في تطور هذا
+
+34
+00:03:40,860 --> 00:03:47,200
+الجنين، وهذا الإنسان، إنه الأصابع ما كانت بالشكل
+
+35
+00:03:47,200 --> 00:03:55,570
+المفصول اللي احنا نتوقعه. هذه اختلالات تطورية، وهذه
+
+36
+00:03:55,570 --> 00:04:04,510
+يعني اكتشفنا بعدين إنه الجينات والعوامل الوراثية
+
+37
+00:04:04,510 --> 00:04:13,670
+بتكون بتتحكم بهذا الأمر. فقضية إنه يعني معرفة هذه
+
+38
+00:04:13,670 --> 00:04:22,160
+الجينات وسببها في حدوث هذا المظهر، هذا الشكل، دورها
+
+39
+00:04:22,160 --> 00:04:27,460
+يعني في قضية تطور الأطراف، تطور الأصابع، تطور
+
+40
+00:04:27,460 --> 00:04:35,380
+الحلق،  اللسان، الأذنين، الرجلين، التطور أي جانب، قضية
+
+41
+00:04:35,380 --> 00:04:40,920
+بدها دراسة، وبدها الواحد يكون على اطلاع عليها. فهنا طبعاً
+
+42
+00:04:42,810 --> 00:04:49,830
+يعني كلمة أسماء نفس
+
+43
+00:04:49,830 --> 00:04:56,950
+الـ Syndromes بحد ذاتهم، ماشي، ما أظن يعني، حتى ولو في
+
+44
+00:04:56,950 --> 00:05:02,370
+الـ US أملي، أو في غيرها من الأسئلة بهمّ الواحد
+
+45
+00:05:02,370 --> 00:05:09,030
+يعني بحد ذاته اسم المرض، بقدر ما أنه كمان الواحد
+
+46
+00:05:09,030 --> 00:05:16,200
+يعني يستخدم الاسم هذا لتذكر مجموعة الأعراض
+
+47
+00:05:16,200 --> 00:05:20,680
+الموجودة، كيف بتكون، وهم ذلك بالذات الأشياء اللي
+
+48
+00:05:20,680 --> 00:05:28,720
+فيها تبين أمور جينية ووراثية، إنه الواحد يشوف شو الـ…
+
+49
+00:05:28,720 --> 00:05:35,800
+الـ Mutation وين موجودة، في أي جين، وليه بيعمل هذا
+
+50
+00:05:35,800 --> 00:05:40,600
+الشيء، والقضايا هذه الـ
+
+51
+00:05:41,110 --> 00:05:48,090
+هنا شيء اسمه يعني congenital arthrogyropsis
+
+52
+00:06:28,550 --> 00:06:35,130
+السلام عليكم، شكله انقطع، ما أعرف، فالحال
+
+53
+00:06:35,130 --> 00:06:40,350
+هنا اللي
+
+54
+00:06:40,350 --> 00:06:49,010
+بيفرجونا بالنسبة للصورة
+
+55
+00:06:49,010 --> 00:06:51,870
+الحديث الولادة هذا، الـ Newborn هذا
+
+56
+00:06:54,730 --> 00:06:59,230
+دكتور، بعد ذلك بستعمل share للشاشة، اللي ليه مش
+
+57
+00:06:59,230 --> 00:07:11,490
+مبينة، أه أه أه، لأنه ما طلعني أهي، أين راحت؟
+
+58
+00:07:27,960 --> 00:07:35,380
+بقول هنا في صورة يعني
+
+59
+00:07:35,380 --> 00:07:43,060
+still birth، يعني ولادة جنين ميت، الاختلالات
+
+60
+00:07:43,060 --> 00:07:52,080
+الموجودة إنه كان الحمل حوالين الجنين، السائل
+
+61
+00:07:52,080 --> 00:07:57,660
+الأمنيوسي، أو الـ Amniotic Fluid كان قليل جداً
+
+62
+00:07:58,130 --> 00:08:05,930
+وكمان نتيجة اختلال في العضلات، أصبح هناك شد شديد
+
+63
+00:08:05,930 --> 00:08:14,930
+ وعدم فاعلية في… عدم
+
+64
+00:08:14,930 --> 00:08:22,350
+فاعلية بالنسبة للعضلات، وبالتالي المفاصل كانت
+
+65
+00:08:22,350 --> 00:08:28,070
+يعني مضروبة بشكل، زي هيك يعني، الإيد مش مفتوحة، الرجل
+
+66
+00:08:28,070 --> 00:08:34,850
+مش مفتوحة، والشكل هذا هنا يعني قضية إنه ما يكونش فيه
+
+67
+00:08:34,850 --> 00:08:42,710
+سائل حوالين الجنين، أحياناً بيكون نتيجة مشاكل في
+
+68
+00:08:42,710 --> 00:08:47,710
+الـ، يعني غالبية السائل اللي حوالين الحمل هو من الـ
+
+69
+00:08:47,710 --> 00:08:51,350
+بالنسبة للجنين نفسه، يعني بالإشارة للإفرازات
+
+70
+00:08:51,350 --> 00:08:57,550
+المشيمة، أو أشياء ثانية. فلما ما يكونش موجود أحياناً
+
+71
+00:08:57,550 --> 00:09:04,330
+بيكون مؤشر على مثلًا فشل كلوي في الجنين، عدم
+
+72
+00:09:04,330 --> 00:09:10,750
+إمكانية إفراز البول، وده ولد بشكل طبيعي، يعني
+
+73
+00:09:10,750 --> 00:09:18,710
+قدرنا يوصل لحد أن يكون، بعد ذلك يولد بشكل طبيعي، هو
+
+74
+00:09:18,710 --> 00:09:25,720
+نحط ملاحظة على الحالة هذه، إنه في هذه الحالة الذكاء
+
+75
+00:09:25,720 --> 00:09:32,120
+والتطور العقلي، العصبي كان طبيعي، وإنه بس بده شغل
+
+76
+00:09:32,120 --> 00:09:39,740
+على عمليات، وبالنسبة لعلاج
+
+77
+00:09:39,740 --> 00:09:49,180
+طبيعي للجوانب العظام، يعني فلما نلاقي الإنسان عنده
+
+78
+00:09:51,700 --> 00:09:59,880
+يعني مشاكل الجانب المهم، لقضية إنه هل هذا مشكلة
+
+79
+00:09:59,880 --> 00:10:05,080
+وراثية ولا لأ، لما نجد الإنسان حالة أو عائلة بمثل
+
+80
+00:10:05,080 --> 00:10:12,080
+هذا الشكل، ننتبه إن الحالة الوراثية بدها تكون أكثر
+
+81
+00:10:12,080 --> 00:10:15,900
+من فرد في العائلة مصاب، يعني إن هذه شغل الواحد بدّه
+
+82
+00:10:15,900 --> 00:10:24,740
+يدور عليها، أو يشوفها، وبدّه يحاول يعني ينتبه لها
+
+83
+00:10:24,740 --> 00:10:27,820
+فأنا
+
+84
+00:10:27,820 --> 00:10:38,680
+بحاول أن أنزل هنا
+
+85
+00:10:38,680 --> 00:10:47,160
+في أحياناً أحداث، يعني أنا أظن بعد ذلك
+
+86
+00:10:51,080 --> 00:11:01,260
+بيحاولوا يتكلموا عنها، إنه لما نشوف حالات وراثية أو
+
+87
+00:11:01,260 --> 00:11:08,340
+يعني اللي هي أكثر من فرد في العائلة، ونحاول
+
+88
+00:11:08,340 --> 00:11:17,980
+نشوف الأمراض الناتجة عنها، سواء في عائلة معينة أو في
+
+89
+00:11:17,980 --> 00:11:27,460
+مجتمع، نجي نعمل دراسة، بنلاقي إنه 20% تقريباً بيكون
+
+90
+00:11:27,460 --> 00:11:33,400
+سببها Single-Gene Defect، يعني هذه اللي هي من
+
+91
+00:11:33,400 --> 00:11:39,200
+المسببات للـ Developmental Malformations، الـ
+
+92
+00:11:39,200 --> 00:11:48,460
+Developmental Anomalies، بنلاقي إنه يكون سببها
+
+93
+00:11:48,460 --> 00:11:54,940
+فقط جين واحد، هذا بيكون تقريباً بنسبة عشرين بالمئة
+
+94
+00:11:54,940 --> 00:12:05,780
+تقريباً. أحياناً في هناك اختلالات وراثية أخرى زي
+
+95
+00:12:05,780 --> 00:12:11,880
+copy number variants في جين معين، مش شغلة Mendelian
+
+96
+00:12:11,880 --> 00:12:16,410
+inheritance، الـ Copy مضروبة أو الـ Copy طبيعية، والـ
+
+97
+00:12:16,410 --> 00:12:20,910
+Copy المضروبة هي اللي أعطت المرض. لأ، بيكون حالات
+
+98
+00:12:20,910 --> 00:12:26,010
+أخرى، مجموعة من الـ، يعني، وفي صورة عنها حتى جزء منها
+
+99
+00:12:26,010 --> 00:12:31,770
+موجود في الكائنات الأخرى مثلًا، وأنا راح أتكلم عنها
+
+100
+00:12:31,770 --> 00:12:37,610
+بباب الـ Drosophila أو غيرها أو كده. ففي مرات وجود
+
+101
+00:12:37,610 --> 00:12:43,300
+أكثر من النسخة، أو عدد النسخ الموجودة بالنسبة لجين
+
+102
+00:12:43,300 --> 00:12:49,780
+معين، فيه هناك أحياناً 25% كروموزوم الـ anomalies
+
+103
+00:12:49,780 --> 00:12:55,860
+فهذه تتكلم تقريباً الواحد على ربع الحالات، ويكون
+
+104
+00:12:55,860 --> 00:13:02,120
+على مستوى قطعة كبيرة من الـ DNA، فالكروموزوم بأكمله
+
+105
+00:13:02,120 --> 00:13:07,200
+ممكن يكون فيه اختلال، وممكن قطعة كبيرة في
+
+106
+00:13:07,200 --> 00:13:13,700
+الكروموزوم. زي ما حكينا مرات في بعض الحالات بتكون
+
+107
+00:13:13,700 --> 00:13:19,760
+بند كبير، قطعة كبيرة يعني، بتكون فيها عدد كبير من
+
+108
+00:13:19,760 --> 00:13:28,620
+الجينات، مش جين واحد. 5% تيراتوجين، تيراتو يعني مسبب
+
+109
+00:13:28,620 --> 00:13:33,280
+للمشاكل
+
+110
+00:13:33,280 --> 00:13:37,400
+التطورية
+
+111
+00:13:37,930 --> 00:13:46,270
+ماشي، اللي هي مثلًا أشهر قصة تتذكروا بالنسبة لشغل
+
+112
+00:13:46,270 --> 00:13:52,730
+Teratogen، دواء اسمه "الثاليدومايد"، "الثاليدومايد"
+
+113
+00:13:52,730 --> 00:14:00,230
+عبارة عن، في الخمسينات، حتى في أمريكا، مبسوطين إن
+
+114
+00:14:00,230 --> 00:14:07,010
+وكالة الدواء والغذاء منعت دخوله من أوروبا لأمريكا
+
+115
+00:14:08,100 --> 00:14:15,420
+فهو عبارة عن دواء مخفف لأعراض الغثيان والإستفراغ
+
+116
+00:14:15,420 --> 00:14:21,340
+وخصوصاً الحوامل، يعني معروف الحوامل بيجي عندهم
+
+117
+00:14:21,340 --> 00:14:25,540
+غثيان وإستفراغ، وبعضاً في أول الحمل، وبعضاً في وسطه
+
+118
+00:14:25,540 --> 00:14:31,460
+وبعضاً، وله هاي أسباب كثيرة. فالـ Thalidomide، دواء
+
+119
+00:14:31,460 --> 00:14:38,620
+أصبح بالذات في أوروبا، لقضية غثيان الحوامل، دواء كثير
+
+120
+00:14:38,620 --> 00:14:44,480
+الانتشار، نتيجة استخدام هذا الدواء، هناك نسبة عالية
+
+121
+00:14:44,480 --> 00:14:53,200
+أو نسبة محترمة من وجود ولود، أو ولادة، أو خلق أطفال
+
+122
+00:14:53,200 --> 00:14:59,580
+بغير أطرافهم، ناشي؟ يعني مافيش إيدين، مافيش رجلين
+
+123
+00:14:59,580 --> 00:15:05,600
+الأربعة، تلاتة، اتنين، يعني التشوهات، يعني الـ
+
+124
+00:15:05,600 --> 00:15:10,920
+Congenital Defect كبير جداً كان
+
+125
+00:15:10,920 --> 00:15:17,780
+هناك، نقص، وباء من قضية ولادة أطفال مشوهين بلا
+
+126
+00:15:17,780 --> 00:15:22,140
+أطراف. فثبت بعدين إن هذا هو الـ Thalidomide كان
+
+127
+00:15:22,140 --> 00:15:31,820
+السبب، ليش وكيف وكذا، كانت
+
+128
+00:15:31,820 --> 00:15:37,440
+تجربة سيئة في العالم، ومنع، الآن الـ Thalidomide هو
+
+129
+00:15:37,440 --> 00:15:47,420
+دواء حكينا إنه قوي جداً، وكويس ضد الغثيان والإستفراغ
+
+130
+00:15:47,420 --> 00:15:53,760
+والقيء، وهو مظاهر مزعجة جداً، وهو فعال جداً. فالآن
+
+131
+00:15:53,760 --> 00:16:00,950
+في حالات قليلة، من مثلًا حالات متقدمة من السرطان
+
+132
+00:16:00,950 --> 00:16:07,370
+وفيها غثيان وإستفراغ، في بعض الحالات الأخرى، لأن
+
+133
+00:16:07,370 --> 00:16:14,670
+يُستخدم. فالـ Thalidomide هو الـ تيراتوجين، وإله
+
+134
+00:16:14,670 --> 00:16:19,770
+قصته، ويعني أنا أظن إنه حتى يعني في الثقافة العامة
+
+135
+00:16:19,770 --> 00:16:26,720
+عند الناس، يعني بالذات أول الحمل، الأم الحامل ما
+
+136
+00:16:26,720 --> 00:16:31,280
+تأخذ أدوية، ويحاول الواحد يبعد عن الأدوية إلا إذا
+
+137
+00:16:31,280 --> 00:16:35,300
+فيه ضرورة لهذا الدواء، من ناحية، ومن ناحية ثانية
+
+138
+00:16:35,300 --> 00:16:45,040
+يكون هذا الدواء مثبت أنه بشكل مفيد، يعني
+
+139
+00:16:45,040 --> 00:16:48,740
+من الجوانب اللي يجب تكون معروفة عند الواحد أن
+
+140
+00:16:48,740 --> 00:16:57,140
+الأدوية بالنسبة للحمل يُقال عنها A و B و C، Class A
+
+141
+00:16:57,140 --> 00:17:06,380
+و Class B و Class C، Class A هو دواء ثبت أمانه وثبت
+
+142
+00:17:06,380 --> 00:17:13,140
+فائدته، يعني إنه لا يسبب أي تأثير سلبي على الحمل
+
+143
+00:17:13,140 --> 00:17:22,570
+Class C يعني ممنوع، وثبت إنه مضر. Class B اللي بالنص
+
+144
+00:17:22,570 --> 00:17:27,070
+يعني اللي يقولها بيقول له "أه ولا لأ"، يعني it
+
+145
+00:17:27,070 --> 00:17:34,630
+wasn't proven teratogenic and dangerous، وممنوع، ولا
+
+146
+00:17:34,630 --> 00:17:40,670
+ثبت أنه آمن، وكويس. هذه بيقول لك أنت كطبيب مع
+
+147
+00:17:40,670 --> 00:17:50,090
+المريضة، بتناقشوا، بتقدروا حسب درجة خطورة وإزعاج
+
+148
+00:17:51,070 --> 00:17:56,170
+التأثير، العرض والمرض، على المريضة، بنعطي الدواء أو
+
+149
+00:17:56,170 --> 00:18:06,090
+لا. فهي النقطة الأساسية إنه أكثر من، يعني فيه
+
+150
+00:18:06,090 --> 00:18:17,210
+هناك حوالي 40% عبارة عن تداخل حالات وأوضاع وراثية
+
+151
+00:18:17,210 --> 00:18:24,480
+Single gene أو Teratogen أو أكثر من خلل في نفس
+
+152
+00:18:24,480 --> 00:18:34,620
+الوقت. فإحنا اللي بنلاحظ هنا إنه تقريباً يعني أكثر
+
+153
+00:18:34,620 --> 00:18:43,560
+من النصف، يعني نتكلم على بعض، 35، 20، 55% عبارة عن
+
+154
+00:18:43,560 --> 00:18:53,980
+حالات Genetic، حالات وراثية، بطرق مختلفة، وبتكون هناك
+
+155
+00:18:53,980 --> 00:19:02,460
+إشكاليات من الـ Multifactorial، قضية اللي حكينا عنها
+
+156
+00:19:02,460 --> 00:19:06,860
+مرة، جيبنا عرض عنها، اللي هي تعويض الـ Folic Acid عند
+
+157
+00:19:06,860 --> 00:19:13,920
+الحوامل، حيث أنه نقص الـ Folic Acid بسبب ما يسمونه
+
+158
+00:19:13,920 --> 00:19:19,760
+الـ Neuronal Tube Defect، عبارة عن اختلالات في تطور
+
+159
+00:19:19,760 --> 00:19:23,840
+الجهاز العصبي بشكل معين، ويصير في حالة بنسميها
+
+160
+00:19:23,840 --> 00:19:31,700
+"Spina Bifida"، يعني إنه فتحة في الحبل الشوكي بحيث
+
+161
+00:19:31,700 --> 00:19:36,860
+إنه ما بيسكر بالشكل السليم، وبالتالي، تطور الأعصاب
+
+162
+00:19:36,860 --> 00:19:44,380
+بيكون بشكل مضروب، وممكن يعني إيه درجات، منها الخفيف
+
+163
+00:19:44,380 --> 00:19:49,170
+كثير، اللي يلاقي  كاد يختلف عن الإنسان الطبيعي، وفي
+
+164
+00:19:49,170 --> 00:19:56,530
+حالات أخرى بتكون شديدة كثيراً، يعني شلل نصف الجسم
+
+165
+00:19:56,530 --> 00:20:04,210
+السفلي مثلًا، بتكون كاملة. يعني الفكرة من المحاضرة
+
+166
+00:20:04,210 --> 00:20:13,010
+اليوم، بقول إن أنا أود أذكر هذه الشريحة
+
+167
+00:20:13,010 --> 00:20:18,640
+وقضية إنه حوالي الخمس هي single gene defect
+
+168
+00:20:18,640 --> 00:20:25,680
+بالأشياء اللي بنشوفها، other forms of genetic
+
+169
+00:20:25,680 --> 00:20:30,800
+anomalies زي copy number of certain chromosome
+
+170
+00:20:30,800 --> 00:20:36,360
+variant أو copy number of certain gene variants
+
+171
+00:20:36,780 --> 00:20:41,220
+حوالي 10% على مستوى الـ Chromosome anomalies تقريباً
+
+172
+00:20:41,220 --> 00:20:48,220
+25%، والبقية تيراتوجين واضح، External، مش شغل
+
+173
+00:20:48,220 --> 00:20:52,880
+الـ Genetic، أو يعني الـ Pure، Non-Genetic Cause
+
+174
+00:20:52,880 --> 00:20:57,460
+حوالي 5% تيراتوجين بدنا نسميه، والبقية هي
+
+175
+00:20:57,460 --> 00:21:00,180
+Interaction between more than one thing، ممكن
+
+176
+00:21:00,180 --> 00:21:05,930
+Environmental مع الـ Genetic، بشكل يعني، الـ More
+
+177
+00:21:05,930 --> 00:21:14,570
+Dilute، "الـ 55%
+
+223
+00:26:05,050 --> 00:26:11,330
+كثير وقرصة بالفيروس هذا بنتج عنه إن حجم الدماغ
+
+224
+00:26:11,330 --> 00:26:22,690
+بيطلع صغير وبيطلع الطفل مشوّه بطريقة ما، فالنقطة
+
+225
+00:26:22,690 --> 00:26:30,730
+اللي بدنا نوصلها إنه العوامل البيئية سواء من ناحية
+
+226
+00:26:30,730 --> 00:26:36,210
+التغذية، سواء من ناحية الالتهابات، يعني في الـ
+
+227
+00:26:36,210 --> 00:26:44,390
+«روبيلا» اللي فيه بيسموه مثلاً من أسباب حتى
+
+228
+00:26:44,390 --> 00:26:49,610
+الإجهاض المبكر أو وفاة الجنين، وكذا بيسموه
+
+229
+00:26:49,610 --> 00:26:57,090
+«التورتش» اللي هي «TORCH» (Toxoplasmosis, Other, Rubella, Cytomegalovirus, Herpes)، يعني مجموعة
+
+230
+00:26:57,090 --> 00:27:03,830
+فيروسات أو بكتيريا تُسبب  تَشَوُّهَات خلقية، اللي هو نوع من
+
+231
+00:27:03,830 --> 00:27:15,410
+الطفيليات حتى، فهناك أسباب كثيرة لحدوث مشاكل خلقية
+
+232
+00:27:15,410 --> 00:27:21,030
+بين قوسين، إحنا بنترجمها، يعني حدوثها خلال التخلق
+
+233
+00:27:21,030 --> 00:27:27,830
+اللي هي congenital، بس يعني حقيقةً الأسباب متعددة
+
+234
+00:27:27,830 --> 00:27:33,350
+والأسباب الوراثية أحياناً ورافية بنسبة كبيرة، بس كمان بيئية
+
+235
+00:27:33,350 --> 00:27:38,330
+بنسبة مقاربة تقريباً، بس أقل شوية، يعني هنا البيئية
+
+236
+00:27:38,330 --> 00:27:46,360
+تقريباً بتيجي 45%، والوراثية بشكل 55%
+
+237
+00:27:46,360 --> 00:27:54,700
+على أقل تقدير، على كلام دراسة معينة، أحياناً
+
+238
+00:27:54,700 --> 00:28:02,500
+يعني أنا الحالات هذه ما قريت قد ايش مسبب حدوثها
+
+239
+00:28:02,500 --> 00:28:12,800
+فبنتبه الواحد للأطفال اللي بيجوا وبشوف كم يعني
+
+240
+00:28:12,800 --> 00:28:13,320
+كم
+
+241
+00:28:15,860 --> 00:28:22,900
+ووجود مجموعة من الظواهر
+
+242
+00:28:22,900 --> 00:28:27,480
+أو الأعراض، أو الـ «symptoms» و«signs»، الأعراض
+
+243
+00:28:27,480 --> 00:28:34,280
+والعلامات اللي بنشوفها، يعني أحياناً بنتبه الواحد
+
+244
+00:28:34,280 --> 00:28:38,480
+إنه تقريباً أنا ممكن أكون شفت حالة زي هيك أو إنسان
+
+245
+00:28:38,480 --> 00:28:45,620
+شكله زي هيك. هنا أسئلة اسمها «ربينشتاين تايبي
+
+246
+00:28:45,620 --> 00:28:54,380
+سندروم»، عبارة عن تخلف عقلي أو تخلف ليس عقلياً فقط،
+
+247
+00:28:54,380 --> 00:29:06,340
+وإنما تخلف أو تأخر نموّي، فتلاقي الأطفال المصابين
+
+248
+00:29:06,340 --> 00:29:14,490
+لهم هنا وجه بشكل معين، يعني Distinctive facial
+
+249
+00:29:14,490 --> 00:29:19,750
+appearance، الأصابع والأبهام أو الأيدين يعني هيك
+
+250
+00:29:19,750 --> 00:29:28,490
+عريضات بشكل أكبر من المتوقع، يعني Large toes، ومشاكل
+
+251
+00:29:28,490 --> 00:29:32,450
+في القلب، فالجميل
+
+252
+00:29:32,450 --> 00:29:37,970
+يعني لما نكون عندنا واحد في العائلة، ليش سموها بهذا الاسم؟
+
+253
+00:29:37,970 --> 00:29:42,450
+اللي هم هذول الاثنين اللي اشتركوا «روفنشتاين» وType B
+
+254
+00:29:42,450 --> 00:29:47,330
+Syndrome، أنا بتوقع على الأقل الـMajor Things اللي
+
+255
+00:29:47,330 --> 00:29:53,750
+أنتوا بتشوفوها وجابها لكم، مش غلط الواحد يقرأ
+
+256
+00:29:53,750 --> 00:29:58,330
+عنها، وعلى الأقل بتعطي الواحد هيك حصيلة جيدة من
+
+257
+00:29:58,330 --> 00:30:03,530
+أسماء أنواع المشاكل الـ
+
+258
+00:30:06,740 --> 00:30:13,200
+لأ، اللي كان دور العالمين هذول في .. يعني ليش
+
+259
+00:30:13,200 --> 00:30:17,820
+حطوا الاسم باسمهم؟ جزء من الموضوع يمكن يكونوا هم
+
+260
+00:30:17,820 --> 00:30:24,500
+أول ناس لقوا عائلة أو درسوها، أو بيحاولوا يدرسوا شو
+
+261
+00:30:24,500 --> 00:30:36,120
+المسبب، فالـ .. هنا القضية إن الموضوع عبارة عن خسارة
+
+262
+00:30:36,120 --> 00:30:45,540
+وظيفة جينين اثنين بشكل قريبين
+
+263
+00:30:45,540 --> 00:30:52,360
+جداً على بعض، عبارة عن الـ Closely Related
+
+264
+00:30:52,360 --> 00:30:59,180
+Transcriptional Coactivators، Transcription، يعني
+
+265
+00:30:59,180 --> 00:31:06,280
+لموضوع عملية تحويل الـ «DNA» إلى الـ «RNA»، يعني
+
+266
+00:31:06,280 --> 00:31:13,720
+نقل وقراءة خط الـ «DNA» واستخلاص المادة الوراثية
+
+267
+00:31:13,720 --> 00:31:18,720
+منه لتحويلها إلى الـ «RNA»، حتى نطلع منها الـ
+
+268
+00:31:18,720 --> 00:31:26,920
+«بروتين»، فيه «coactivators» معينة، CBP يعني
+
+269
+00:31:26,920 --> 00:31:37,280
+عصا لفوق، وبعدين B لتحت، عصا لتحت، أو EP300، فهذه
+
+270
+00:31:37,280 --> 00:31:40,920
+الطريقة.
+
+271
+00:31:40,920 --> 00:31:45,320
+وهذه الظواهر
+
+272
+00:31:45,320 --> 00:31:51,640
+ما هي علاقتها بشكل مباشر بهذا الـ «جين» بهذه
+
+273
+00:31:51,640 --> 00:31:57,560
+الطريقة؟ بتكون لسه من الأسرار اللي ربنا بيمتلكها،
+
+274
+00:31:57,560 --> 00:32:03,460
+وكل ما يكتشف الواحد أشياء بيكتشف اللي لسه مش عارف.
+
+275
+00:32:03,460 --> 00:32:10,860
+أحياناً المظهر اللي إحنا بنشوفه هو نتيجة خلل في
+
+276
+00:32:10,860 --> 00:32:18,210
+جانب معين، وزي ما أنتم لاحظين، قضية أنّه الوجه،
+
+277
+00:32:18,210 --> 00:32:23,370
+الأطراف، القلب، يعني مؤثر على كذا محل في جسم
+
+278
+00:32:23,370 --> 00:32:29,090
+الإنسان، والنمو مش طبيعي، هناك
+
+279
+00:32:29,090 --> 00:32:38,970
+يعني ظواهر، يعني النقطة
+
+280
+00:32:38,970 --> 00:32:44,870
+اللي بحكوا عنها بالنسبة للي حطيناها قبل شوية، كان قدرنا
+
+281
+00:32:44,870 --> 00:32:51,370
+نصل إلى أنّ هذين الجينين اللي عاملين الاختلال
+
+282
+00:32:51,370 --> 00:32:58,110
+اللي إحنا شفناه من المظاهر اللي شفتوها أو المفروض
+
+283
+00:32:58,110 --> 00:33:04,350
+يعني هي تعتبر جزء من الـ Anatomy، اللي هي قضية الـ
+
+284
+00:33:04,350 --> 00:33:08,790
+Embryology، الـ Embryology، كيف الإنسان بيتخلق وكيف
+
+285
+00:33:08,790 --> 00:33:12,990
+الخلايا بتهاجر وكيف بتنمو بهذا الشكل.
+
+286
+00:33:16,740 --> 00:33:24,000
+الـ… الـ… الـEmbryogenesis، بالأخير، هجرة الخلايا
+
+287
+00:33:24,000 --> 00:33:28,940
+زي حتى خلايا المناعة أو خلايا الدم، تبدأ في كيس
+
+288
+00:33:28,940 --> 00:33:34,980
+المح، اللي هي في الـEgg Yolk، تنتقل للـLiver
+
+289
+00:33:34,980 --> 00:33:39,340
+والـSpleen، للكبد والطحال، وبعدين تنتقل في الـBone
+
+290
+00:33:39,340 --> 00:33:43,930
+Marrow، بس يولد الإنسان بتبين بالـBone Marrow، بالـ
+
+291
+00:33:43,930 --> 00:33:48,110
+Bone Marrow، وبشكل أساسي هذه الهجرة أو هذا التنقل أو هذا
+
+292
+00:33:48,110 --> 00:33:58,730
+التطور عبارة عن ظواهر محكومة بدوافع، بمؤشرات، أو
+
+293
+00:33:58,730 --> 00:34:02,390
+بـ، يعني فيه شيء بيقول للخلية: اتركي هنا، وروح
+
+294
+00:34:02,390 --> 00:34:10,550
+هناك، فيه شيء بيقول للخلية: اعملي هيك، وسوي هيك، ففي
+
+295
+00:34:10,550 --> 00:34:16,190
+حالة، يمكن حتى إذا دخلنا باللي قبل شوية، نسميها الـ
+
+296
+00:34:16,190 --> 00:34:23,130
+Pierre Robin Sequence، من المشاكل، أحياناً بعض الناس الأصل
+
+297
+00:34:23,130 --> 00:34:27,970
+في الإنسان الـNormal، يعني تخيلنا هذه الصورة، إنه
+
+298
+00:34:27,970 --> 00:34:35,070
+تكون الذقن السفلي أو الفك السفلي، حجم معين، بيكون
+
+299
+00:34:35,070 --> 00:34:37,410
+يعني
+
+300
+00:34:38,140 --> 00:34:45,640
+متكون بشكل طبيعي، بحيث أنه يعطي مجال للسان ينمو
+
+301
+00:34:45,640 --> 00:34:52,660
+بشكل طبيعي، أحياناً حتى بعض الناس بيكون الذقن تبعه
+
+302
+00:34:52,660 --> 00:34:58,460
+يمكن متراجع للخلف، يعني وراثي، بتشوف شكل الوجه
+
+303
+00:34:58,460 --> 00:35:03,320
+كيف، في تقارب بين الأباء والأمهات، بتلاقي بعض الناس
+
+304
+00:35:03,320 --> 00:35:10,620
+الذقن جاي لورا، وبنسميه الـ Receding أو Hypoplasia
+
+305
+00:35:10,620 --> 00:35:15,240
+of the mandible، وPosterior displacement of the
+
+306
+00:35:15,240 --> 00:35:19,720
+tongue، يعني اللي هي زي ما هم شايفين هنا، يعني هي
+
+307
+00:35:19,720 --> 00:35:28,200
+أحياناً حتى إنسان يولد بشكل طبيعي، يعني قضية، إذا
+
+308
+00:35:28,200 --> 00:35:32,760
+حدّ بشوف، يعني البارحة بتطلع انتخابات أمريكية،
+
+309
+00:35:32,760 --> 00:35:40,160
+الرئيس، المرشح، الشيوخ «السنيتورز» الأمريكي، «جون
+
+310
+00:35:40,160 --> 00:35:45,920
+مكاين»، يظن اسمه، واحد بيشوف الفك السفلي راجع لورا
+
+311
+00:35:45,920 --> 00:35:55,100
+كتير، والـ «لسان» بيكون لسانه مش ماخذ مكانه السليم،
+
+312
+00:35:55,100 --> 00:36:01,020
+وبالتالي هذا ممكن يسبب شخير، ممكن يسبب ضيق في
+
+313
+00:36:01,020 --> 00:36:08,980
+المجال التنفسي، وإشكالات، ممكن يعمل مشاكل، فجزء من
+
+314
+00:36:08,980 --> 00:36:12,840
+المشاكل، طبعاً فيه اللي بيسموها الشفة الأرنبية و
+
+315
+00:36:12,840 --> 00:36:18,820
+الحنك المشقوق، ويعني عبارة عن  تَشَوُّه في  تطوّر الـ «Embryogenesis» في
+
+316
+00:36:18,820 --> 00:36:24,200
+هذه المنطقة في الفم، والأعلى الشفة العليا بيصير
+
+317
+00:36:24,200 --> 00:36:26,200
+«Cleft Lip» و«Cleft Palate».
+
+318
+00:36:31,470 --> 00:36:37,930
+بالعربية، ويكون هنا فيه مشكلة في الـ Cleft-lip والحنك
+
+319
+00:36:37,930 --> 00:36:44,270
+المشقوق، الإنسان الطبيعي بيكون هكذا، أنا شكله طبعاً تحت
+
+320
+00:36:44,270 --> 00:36:52,110
+بينهم، هدول في الدار الخلفي للحلق بتلاقي tonsils،
+
+321
+00:36:52,110 --> 00:36:58,550
+وبتلاقي لسان، الأصل يكون بشكل معين، عندهم هذه
+
+322
+00:36:58,550 --> 00:37:05,320
+المشكلة، أحياناً بنلاقي مش هيك، شكل مدبب لفتحة الحلق،
+
+323
+00:37:05,320 --> 00:37:17,700
+بتلاقيها مش V، على شكل U فتحة الحلق، وبالتالي هذه
+
+324
+00:37:17,700 --> 00:37:25,920
+ممكن تكون من المشاكل التطورات الخلقية هذه، تبدأ
+
+325
+00:37:26,650 --> 00:37:31,570
+يعني ممكن واحد يلاحظها من الاسبوع الـ11، السابع
+
+326
+00:37:31,570 --> 00:37:36,370
+عشر من الحمل، للأسبوع العشرين، للأسبوع التاسع والعشرين،
+
+327
+00:37:36,370 --> 00:37:43,710
+كيف الإنسان بيتطور، والخلايا بتهاجر وبتكبر وبتصير
+
+328
+00:37:43,710 --> 00:37:48,830
+الـDevelopment تبعه، يعني لو أحد شاف عائلة عندها
+
+329
+00:37:48,830 --> 00:37:53,760
+هذه الظاهرة، أو بعض الأفراد، أحلى شيء وأحسن شيء يكون
+
+330
+00:37:53,760 --> 00:37:57,760
+مجموعة مصابين عندهم المرض، ومجموعة مش مصابين في نفس
+
+331
+00:37:57,760 --> 00:38:03,200
+العائلة، في هذه الحالة ممكن تروح الواحد يدور على
+
+332
+00:38:03,200 --> 00:38:10,340
+المشاكل، أو وين المشكلة فيها، في
+
+333
+00:38:10,340 --> 00:38:20,010
+موضوع مهم كثير، يعني إيه دخل بالدين وبالعقيدة،
+
+334
+00:38:20,010 --> 00:38:30,750
+وبالكيف بيميز الواحد حاله عن الآخرين؟ قضية يعني
+
+335
+00:38:30,750 --> 00:38:35,670
+إحنا مقتنعين إن الله سبحانه وتعالى خلق آدم وحواء
+
+336
+00:38:35,670 --> 00:38:41,890
+من خلق مباشر، وبغير واسطة، يعني
+
+337
+00:38:44,160 --> 00:38:51,780
+بشكل مباشر، يعني ما تطوّرنا من، بين قوسين، قرد، أو أصل
+
+338
+00:38:51,780 --> 00:38:59,720
+شيء مشابه للقرد، وانشقّنا عنهم وكذا، الآن الإيمان
+
+339
+00:38:59,720 --> 00:39:07,780
+بهذا الجانب، صحيح، والإيمان دائماً بقول بالـ
+
+340
+00:39:07,780 --> 00:39:11,760
+غيب، مجموعة بتقول الإيمان بالغيب، يعني الإيمان
+
+341
+00:39:11,760 --> 00:39:17,770
+إنك أنت، هذا جانب ربنا حكى عنه: «ما أشهدتهم خلق
+
+342
+00:39:17,770 --> 00:39:21,770
+السماوات والأرض، ولا خلق أنفسهم، وما كنتم اتخذوا
+
+343
+00:39:21,770 --> 00:39:26,830
+المشركين أولياء»، يعني ربنا قرر، والقرآن ما أظن أن
+
+344
+00:39:26,830 --> 00:39:33,610
+حداً أثبت أنه فيه جانب مخطئ أو خاطئ، فربنا حكى: «أنا
+
+345
+00:39:33,610 --> 00:39:38,330
+ما فرجيتكم كيف خلقتكم، كيف بدأتكم، كيف كذا»، وهذا
+
+346
+00:39:38,330 --> 00:39:42,150
+يعني جانب
+
+347
+00:39:43,270 --> 00:39:54,390
+أنا مؤمن به، ولكن هذا الإيمان لا يتنافى مع طلب الله
+
+348
+00:39:54,390 --> 00:40:04,010
+أيضاً، إنّ النظر، وتفكير العقل، وتفكير
+
+349
+00:40:04,010 --> 00:40:10,870
+أو إطلاق نشاط الدماغ، ربنا كرّم آدم، وخلّى الملائكة
+
+350
+00:40:10,870 --> 00:40:20,740
+تسجد له، رفض بعضها، أو رفضهم واستغرابهم لقضية إنه
+
+351
+00:40:20,740 --> 00:40:27,660
+عندنا عقل، شغلناه، يعني لما
+
+352
+00:40:27,660 --> 00:40:32,860
+ربنا طلب من الملائكة تسمية أسماء شيء معين، يعني زي
+
+353
+00:40:32,860 --> 00:40:39,140
+أعطاهم مسألة أو أعمال
+
+354
+00:40:39,140 --> 00:40:41,300
+العقل والذهن والتفكير.
+
+355
+00:40:43,830 --> 00:40:51,930
+فهذا هو ما يميز الإنسان، هو مناطق التفكير، الإنسان، فإنّ
+
+356
+00:40:51,930 --> 00:40:59,270
+الواحد ينظر كيف ربنا بيخلق الأشياء، أحياناً
+
+357
+00:40:59,270 --> 00:41:05,070
+اللادينيين رفضوا، بين قوسين، خصوصاً في المجتمع
+
+358
+00:41:05,070 --> 00:41:10,490
+الغربي، الكنيسة، لأن الكنيسة أجرمت
+
+359
+00:41:12,660 --> 00:41:19,420
+كانت تحاول تَقْيِيد قدرة العالم على الدراسة، وعلى
+
+360
+00:41:19,420 --> 00:41:26,080
+التفكير، وعلى الاستنتاج، أنا أقول التشابهات اللي
+
+361
+00:41:26,080 --> 00:41:33,120
+دفعت بعض العلماء إلى القبول
+
+362
+00:41:33,120 --> 00:41:37,940
+أو المناداة بالتطور، والـEvolution
+
+363
+00:41:39,830 --> 00:41:46,930
+إن الكائنات الحية تطورت من بعض، هذا كلام صحيح، وفي
+
+364
+00:41:46,930 --> 00:41:50,050
+تشابهات
+
+365
+00:41:50,050 --> 00:41:57,670
+معينة بين الكائنات في طريقة بنائها، طريقة عملها،
+
+366
+00:41:57,670 --> 00:42:04,370
+أنا أقول، يعني، بدي أفهمها لوحدها، على إنها مؤشرة
+
+367
+00:42:04,370 --> 00:42:12,270
+على إن الخالق واحد، المنشئ واحد، وهذه أكفأ وأحسن
+
+368
+00:42:12,270 --> 00:42:15,470
+و، يعني
+
+369
+00:42:15,470 --> 00:42:19,650
+لما ربنا قد كتب لنا في الزبور، من بعد الذكر، أنّ الأرض
+
+370
+00:42:19,650 --> 00:42:25,230
+يرثها عبادي الصالحون، الصالحون، يعني هنا يمكن يكون
+
+371
+00:42:25,230 --> 00:42:29,470
+على مستوى، إذا أردنا البشر، من الصالحين من البشر،
+
+372
+00:42:29,470 --> 00:42:38,540
+ولكن على مدى، كما نرى في الأحافير، وفي الـسجل
+
+373
+00:42:38,540 --> 00:42:46,920
+القديم لتكوين الخلق على الأرض، بنلاقي إنه يعني
+
+374
+00:42:46,920 --> 00:42:54,100
+هناك تطور بشكل معين، يعني، فمن الأشياء اللي أجدها
+
+375
+00:42:54,100 --> 00:42:58,900
+مثيرة، وبحاول أقرأ عنها وأدرسها، راح نيجي على جانب
+
+376
+00:42:58,900 --> 00:43:06,630
+آخر، فيه تشابه، يتطور الإنسان بالذات في مرحلة
+
+377
+00:43:06,630 --> 00:43:11,330
+الجنين،
+
+378
+00:43:11,330 --> 00:43:16,270
+وبعد ذلك الولادة، وبعد ذلك النمو والبلوغ، ثم بعد ذلك
+
+379
+00:43:16,270 --> 00:43:26,890
+الهرم والوفاة، فالإنسان هنا بيحاول أن يظهروا
+
+380
+00:43:26,890 --> 00:43:34,870
+مدى تشابه أو اختلاف التركيب العظمي، يعني هذا جانب
+
+381
+00:43:34,870 --> 00:43:43,810
+مهم في علم الأحافير، وعلم تحديد الأجناس، وتحديد ما
+
+382
+00:43:43,810 --> 00:43:48,790
+هو الكائن اللي هذه العظمة منه، يعني دراسة الإضاءة،
+
+383
+00:43:48,790 --> 00:43:56,160
+فمن دراسات الإضاءة المهمة، أنّ أرقى كائن حي، ولقد
+
+384
+00:43:56,160 --> 00:44:00,800
+خلقنا الإنسان في أحسن تقويم، اللي هو الإنسان، يعني
+
+385
+00:44:00,800 --> 00:44:08,280
+حقيقة أنّ الإنسان يقف منتصب على رجلين، ويداه حرّتان،
+
+386
+00:44:08,280 --> 00:44:14,500
+يُحرّكهما كما يشاء، في إن الواحد بيكتب، برسم، بيشتغل
+
+387
+00:44:14,500 --> 00:44:20,720
+بيده، بآلة، كذا كذا، هذه قضية يعني سبحان الله، معجزة
+
+388
+00:44:20,720 --> 00:44:28,520
+ورائعة، ودرجة الخلق
+
+389
+00:44:28,520 --> 00:44:34,260
+المتقن المحكم، كبيرة جداً، فحتى يقف الإنسان بهذا
+
+390
+00:44:34,260 --> 00:44:43,120
+الشكل، يجب أن تكون عظامه بشكل محدد، فإن عظمة العضد
+
+391
+00:44:43,120 --> 00:44:49,690
+أو الـ Humerus، وبعدين الـ Fore
+
+445
+00:50:55,300 --> 00:51:02,680
+يتوقفوا عن محاولة شرح من الذي قام بذلك، كيف قام
+
+446
+00:51:02,680 --> 00:51:08,240
+بذلك لأن هذه أمور مجهولة بالنسبة للمُغيب، ويبقى أن
+
+447
+00:51:08,240 --> 00:51:17,560
+نؤمن بها بالغيب، ففي كثير مما نراه من
+
+448
+00:51:17,560 --> 00:51:24,270
+خلق الإنسان بشكل معين، نجده في الطبيعة، وأحيانًا يعني
+
+449
+00:51:24,270 --> 00:51:31,710
+هذه استجابة لضغوطات معينة، أو لماذا؟ يعني لأنها بتعطي
+
+450
+00:51:31,710 --> 00:51:36,510
+فائدة للكائن الحي الذي يتجدد من ناحية، يعني لماذا الزرافة
+
+451
+00:51:36,510 --> 00:51:41,270
+رقبتها طويلة؟ أقول لك لأن الكائنات على مدى، يعني
+
+452
+00:51:41,270 --> 00:51:45,690
+بالحفر التي نراها، لما تكون الرقبة طويلة كثيرًا،
+
+453
+00:51:45,690 --> 00:51:50,010
+تستطيع أن تأكل طعامًا لا يصل إليه أحد من الكائنات التي
+
+454
+00:51:50,010 --> 00:51:57,410
+ترعى، تكون على مستوى أصغر أو أقل، وهكذا تجد أنه فيه
+
+455
+00:51:57,410 --> 00:52:03,450
+دافع معين للتطور بشكل معين، يعني أنا أظن أن التطور
+
+456
+00:52:03,450 --> 00:52:10,870
+والانتخاب الطبيعي وغيرها من الظواهر هي أدوات يقوم
+
+457
+00:52:10,870 --> 00:52:19,410
+الله سبحانه وتعالى باستخدامها للتغيير، وإن كان كل
+
+458
+00:52:19,410 --> 00:52:27,610
+شيء بقدر من الله سبحانه وتعالى. هناك حالة، هي
+
+459
+00:52:27,610 --> 00:52:34,390
+ما يسمى بـ Proteus Syndrome، يعني الغريب، يعني هذه
+
+460
+00:52:34,390 --> 00:52:41,010
+حالة، وأنا الآن أقرأ عن تفاصيلها، هي
+
+461
+00:52:41,010 --> 00:52:49,250
+Developmental، يعني قضية التطور، هناك اختلالات في
+
+462
+00:52:49,250 --> 00:52:58,140
+معدلات تطور الأعضاء في جسم الإنسان، يعني كما هنا
+
+463
+00:52:58,140 --> 00:53:05,020
+يُعطينا مثال عليه طفل عندما يولد، يولد بشكل طبيعي
+
+464
+00:53:05,020 --> 00:53:11,640
+وأحجام أعضائه متناسقة، ولكن بعد السنة الأولى، يحدث ما
+
+465
+00:53:11,640 --> 00:53:19,060
+يعني يولد بشكل متناسق، متساوي في جميع الأعضاء، عبارة
+
+466
+00:53:19,060 --> 00:53:28,560
+عن أن مجموعة، مثلًا، الرجلان، صارت أصابع رجليه تكبر
+
+467
+00:53:28,560 --> 00:53:37,020
+بشكل غير متناسب، جزء من وجهه نما وجزء لم ينمُ، جزء
+
+468
+00:53:37,020 --> 00:53:42,800
+من جسمه نما وجزء آخر لم ينمُ، هذا يسمى الـ Proteus
+
+469
+00:53:42,800 --> 00:53:54,060
+Syndrome، والآن، يعني، لقوا أنه يوجد  Activator معين،
+
+470
+00:53:54,060 --> 00:54:02,040
+Transcriptional Activator في موقع آخر، فالفكرة، يعني،
+
+471
+00:54:02,040 --> 00:54:09,320
+هنا التي يريدون أخذها، أنه لماذا تحدث، أنه في مجموعة
+
+472
+00:54:09,320 --> 00:54:16,340
+خلايا نمت بشكل، بالـ Proteus Syndrome، هذا يعني
+
+473
+00:54:16,340 --> 00:54:25,820
+نمت بشكل أكبر من غيرها. بدأت تتذكر أن الإنسان يبدأ
+
+474
+00:54:25,820 --> 00:54:31,300
+من fertilized egg، من خلية بويضة ملقحة طبعًا،
+
+475
+00:54:31,300 --> 00:54:35,140
+البويضة قبل التلقيح تكون قريبة من هذا الشكل، تكون
+
+476
+00:54:35,140 --> 00:54:38,940
+فيه two polar bodies، طبعًا هذه صور في الغالب
+
+477
+00:54:38,940 --> 00:54:44,560
+أخذوها من الـ In-vitro fertilization، هذه القضية من
+
+478
+00:54:44,560 --> 00:54:49,830
+السبعينات والثمانينات بدأت، التلقيح الصناعي والتلقيح
+
+479
+00:54:49,830 --> 00:54:55,650
+خارج الجسم للإناث أو النساء اللاتي لديهن مشاكل في
+
+480
+00:54:55,650 --> 00:55:00,370
+الـ Fallopian Tubes، يعني هنّ لديهن كل شيء آخر
+
+481
+00:55:00,370 --> 00:55:07,370
+طبيعي، المبيض طبيعي، الرحم طبيعي، ولكن طرف الرحم عند
+
+482
+00:55:07,370 --> 00:55:16,350
+المبيض فيه تسكير في الطريق وإغلاق، فكان الحل أنّهُما
+
+483
+00:55:16,350 --> 00:55:23,210
+تصير عملية التبويض عند الأنثى، هذه تأخذ البويضة
+
+484
+00:55:23,210 --> 00:55:28,010
+لأنّ الـ IVF يحفظون إنتاج البويضات حتى يكون عندنا
+
+485
+00:55:28,010 --> 00:55:33,310
+عدد كبير من البويضات حتى يكون فيه احتمالية حمل
+
+486
+00:55:33,310 --> 00:55:40,370
+كبيرة، يعني الأصل بعد ما يعملوا عملية التلقيح
+
+487
+00:55:40,370 --> 00:55:44,990
+ويتكون الأمر سليمًا،
+
+488
+00:55:45,370 --> 00:55:49,470
+في عملية الإرجاع للرحم، لازم يعني ثلاث بيضات
+
+489
+00:55:49,470 --> 00:55:54,290
+مخصبة، ليرجعوها، لكي يكون فيه احتمالية أن يكون
+
+490
+00:55:54,290 --> 00:55:59,010
+فيه حمل صحيح، فَاللذين بدأوا يتذكرون أن من الأشياء
+
+491
+00:55:59,010 --> 00:56:05,650
+التي تم دراستها، قضية أن الخلية هذه تنقسم إلى
+
+492
+00:56:05,650 --> 00:56:10,370
+خليتين بعد التلقيح، والخليتين تصبحان أربعة، الخ...
+
+493
+00:56:10,370 --> 00:56:14,090
+وبعدين هؤلاء الأربع تصبح ثمانية، وبعدين ستة عشر،
+
+494
+00:56:15,270 --> 00:56:22,350
+يومين، أو كل يوم، يعني الـ Day Zero هنا، هي
+
+495
+00:56:22,350 --> 00:56:29,570
+fertilized egg واحدة فقط، بعد يوم تصبح خليتين، بعد
+
+496
+00:56:29,570 --> 00:56:36,030
+يوم ثالث، اليوم الثاني تصبح أربعة، يعني هذه
+
+497
+00:56:36,030 --> 00:56:45,610
+متوالية هندسية، اثنان أس عدد الأيام،  ماشي؟  ليس نسبة
+
+498
+00:56:45,610 --> 00:56:55,670
+سرعة في النمو عالية جدًا، فيه
+
+499
+00:56:55,670 --> 00:57:04,090
+دائمًا مثل، أو كلمة، أسرع سرطان في نمو، نموًا في
+
+500
+00:57:04,090 --> 00:57:12,100
+الجسم هو الجنين الطبيعي، يبدأ من خلية واحدة، تتحول
+
+501
+00:57:12,100 --> 00:57:17,340
+إلى، عندما يولد الإنسان عادةً، يعني ثلاثة أو أربعة كيلوغرامات،
+
+502
+00:57:17,340 --> 00:57:23,780
+ماشي؟ زائد المشيمة زائد السائل الأمنيوسي وكذا، ويكون
+
+503
+00:57:23,780 --> 00:57:28,140
+له حجم كبير، بالنسبة
+
+504
+00:57:28,140 --> 00:57:33,660
+لـ عملية الـ In vitro fertilization، يستطيعون
+
+505
+00:57:33,660 --> 00:57:39,440
+مراقبة تطور هذه الخلايا بشكل يومي، بشكل دقيق، هكذا
+
+506
+00:57:39,900 --> 00:57:48,200
+فطبعًا بتكون صورها بهذا الشكل، ونتكلم يعني على أنه
+
+507
+00:57:48,200 --> 00:57:54,280
+بعد ذلك تصبح، يعني، ما هي مراحل النطفة، العلقة،
+
+508
+00:57:54,280 --> 00:57:58,380
+المضغة،  الـ...  يعني التي ذكرها الله سبحانه وتعالى، حقيقةً
+
+509
+00:57:58,380 --> 00:58:04,880
+أجمل وصف للتطور الذي نشاهده، الـPlastocyst، هذه
+
+510
+00:58:04,880 --> 00:58:11,180
+هي تصل إلى مرحلة العلقة التي يُفترض أنها تلتصق في
+
+511
+00:58:11,180 --> 00:58:18,980
+جدار الرحم، وبالتالي، يعني، بعدين تنمو
+
+512
+00:58:18,980 --> 00:58:25,580
+داخلها بحيث تكون Machine، أو تكون الطبقات، هي
+
+513
+00:58:25,580 --> 00:58:35,810
+كيس الحمل بهذا الشكل، الإنسان سيتكون من مجموعة
+
+514
+00:58:35,810 --> 00:58:39,550
+الخلايا التي هنا، التي في الطبقة هذه، كل هذا
+
+515
+00:58:39,550 --> 00:58:45,230
+بالـ Embryology،  يُفترض أن تكونوا قد أخذتموها، وهنا الـ
+
+516
+00:58:45,230 --> 00:58:48,650
+Amniotic Fluid، الـ Amniotic Cavity، يبدأ يتكون
+
+517
+00:58:48,650 --> 00:58:53,810
+ويتشكل، لما هنا تلتصق في الرحم، نحن هنا في مرحلة
+
+518
+00:58:53,810 --> 00:59:02,710
+العلقة، فالفكرة أنّه أحيانًا، يعني، كلّ، يعني هناك فكرة
+
+519
+00:59:02,710 --> 00:59:11,380
+تامة، الفكرة الأولى أنّ أي خلية حتى تتحرك وتسير وتنتقل
+
+520
+00:59:11,380 --> 00:59:19,020
+بهذا الاتجاه، يجب أن يكون ناتجًا عن عوامل تُخبرُها
+
+521
+00:59:19,020 --> 00:59:24,600
+بأنّها تتحرك بهذا الاتجاه، فنجد أن مجموعة Activator
+
+522
+00:59:24,600 --> 00:59:30,480
+Genes، Activator Proteins، هما السبب في أن تتحرك
+
+523
+00:59:30,480 --> 00:59:35,890
+الخلية بهذا الاتجاه، ودراسة هذا الموضوع أحيانًا من
+
+524
+00:59:35,890 --> 00:59:42,370
+الدراسات المهمة التي توضح لنا كيف خلقنا الله سبحانه وتعالى
+
+525
+00:59:42,370 --> 00:59:47,450
+وكيف الخلايا تتحرك بهذا الشكل، فهنا صورة لمراحل
+
+526
+00:59:47,450 --> 00:59:56,030
+بداية التصاق الـ Blastocyst، التي هي العلقة، الفكرة
+
+527
+00:59:56,030 --> 01:00:00,810
+أيضًا أن هناك سيكون تخصص لكل خلية،
+
+528
+01:00:04,260 --> 01:00:09,000
+فمثلًا، خلايا الدم، وفيها خلايا المناعة من
+
+529
+01:00:09,000 --> 01:00:12,340
+أنواع مختلفة، الـ Liver and Joints، يعني
+
+530
+01:00:12,340 --> 01:00:17,820
+الـ Lymphocytes، التي هي الخلايا الليمفاوية، ليست أقل
+
+531
+01:00:17,820 --> 01:00:23,560
+من 30 نوع خلية، كل واحدة
+
+532
+01:00:23,560 --> 01:00:31,200
+لها مُحددات حتى تسير بهذا الاتجاه، فخلايا الدم
+
+533
+01:00:32,620 --> 01:00:39,200
+الخلية الجذعية المُكوّنة لخلايا الدم تنقسم بشكل
+
+534
+01:00:39,200 --> 01:00:44,700
+ملحوظ إلى نوعين، فيه ما يسمى الـ Myeloid Series والـ
+
+535
+01:00:44,700 --> 01:00:49,920
+Lymphoid Series، الـ Myeloid Series مثلًا جزء منها
+
+536
+01:00:49,920 --> 01:00:53,700
+ما سيعطينا خلية الدم الحمراء التي تحمل الـ
+
+537
+01:00:53,700 --> 01:00:56,340
+Hemoglobin، التي بدأنا نضيفها، تعطينا الـ Oxygen
+
+538
+01:00:56,340 --> 01:01:02,170
+وتنقله في الجسم في الجهاز الدوري، الخلية التي
+
+539
+01:01:02,170 --> 01:01:10,250
+ستصبح خلية دم حمراء يجب أن تتطور بشكل
+
+540
+01:01:10,250 --> 01:01:14,690
+محدد، وتبني الـ Hemoglobin، وبعدين تفقد الـ Nucleus،
+
+541
+01:01:14,690 --> 01:01:17,690
+وبعدين، الخ... الـ Megakaryocytes تتحول إلى
+
+542
+01:01:17,690 --> 01:01:25,330
+الـ Platelets، الـ Others، سواء خلايا الحبيبية
+
+543
+01:01:25,330 --> 01:01:27,850
+مثل الـ Neutrophils والـ Eosinophils والـ Basophils
+
+544
+01:01:27,850 --> 01:01:31,910
+والحَمْدُلِلهِ، تكون باتجاه معين، والـ Monocytes،
+
+545
+01:01:31,910 --> 01:01:32,770
+Monocytes Monocytes Monocytes Monocytes
+
+546
+01:01:32,770 --> 01:01:33,850
+Monocytes Monocytes Monocytes Monocytes
+
+547
+01:01:33,850 --> 01:01:34,950
+Monocytes Monocytes Monocytes Monocytes
+
+548
+01:01:34,950 --> 01:01:38,510
+Monocytes Monocytes Monocytes Monocytes
+
+549
+01:01:38,510 --> 01:01:39,650
+Monocytes Monocytes Monocytes Monocytes
+
+550
+01:01:39,650 --> 01:01:50,110
+Monocytes Monocytes Monocytes Monocytes
+
+551
+01:01:50,110 --> 01:01:55,090
+Monocytes،
+
+552
+01:01:55,090 --> 01:01:59,170
+وَبِعَرْفِ ما هي المحددات التي تمشي بهذا الاتجاه،
+
+553
+01:01:59,170 --> 01:02:03,910
+يعني نتذكر أن الـ Red Blood Cells، حتى تتحرك الخلايا،
+
+554
+01:02:03,910 --> 01:02:06,950
+وتكون Red Blood Cells، نحتاج هرمون الـ
+
+555
+01:02:06,950 --> 01:02:11,790
+Erythropoietin، يعني أنا أحكي للواحد، بتذكر أن الـ
+
+556
+01:02:11,790 --> 01:02:17,210
+Erythropoietin عبارة عن هرمون يعمل على الخلايا
+
+557
+01:02:17,210 --> 01:02:21,930
+التي ستصبح Red Blood Cells، طبعًا هو هرمون عبارة عن
+
+558
+01:02:21,930 --> 01:02:27,060
+بروتين، و يحتاج إلى مستقبل، فـ Expression،
+
+559
+01:02:27,060 --> 01:02:32,920
+وظهور المستقبل هو أول اختلال أو تغيير أراه
+
+560
+01:02:32,920 --> 01:02:36,640
+في الـ Myeloid Progenitor،  لكي نعرف أن هذا سيصبح
+
+561
+01:02:36,640 --> 01:02:40,640
+Red Blood Cells، بعد ذلك لأن الخلية لازم تعرض الـ
+
+562
+01:02:40,640 --> 01:02:44,620
+Erythropoietin Receptor، وبعدين الـ Erythropoietin
+
+563
+01:02:44,620 --> 01:02:50,540
+يأتي، ويجعلها تذهب بهذا الاتجاه،
+
+564
+01:02:51,390 --> 01:02:57,230
+الـ Platelets، الـ Thrombopoietin، قالوا وجدوه،
+
+565
+01:02:57,230 --> 01:03:03,150
+كانوا يقولون قبل الـ Interleukin 11، مثلًا، الـ
+
+566
+01:03:03,150 --> 01:03:07,850
+Monocytes والـ T cells والـ B cells، كلهم تحت
+
+567
+01:03:07,850 --> 01:03:14,610
+تأثير مؤشرات خارجية، والمؤشرات الخارجية هذه الـ
+
+568
+01:03:14,610 --> 01:03:20,340
+External، تعمل على المستقبلات، والمستقبلات تعمل
+
+569
+01:03:20,340 --> 01:03:25,840
+داخل الخلية من خلال مُنشّطات مُحدّدة، فكل هذه
+
+570
+01:03:25,840 --> 01:03:31,620
+الأنظمة سبحان الله أحيانًا تُسبب الأمراض،
+
+571
+01:03:31,620 --> 01:03:36,640
+وضروري أن نفهمها الآن،
+
+572
+01:03:36,640 --> 01:03:45,880
+هناك، يعني، دفعة قوية لطريقة الاستفادة من قدرة
+
+573
+01:03:45,880 --> 01:03:55,350
+الخلايا على إنتاج أعضاء وأنسجة بشكل مُختلف، وهي
+
+574
+01:03:55,350 --> 01:04:04,190
+قضية العلاج بالخلايا الجذعية، جزء من قدرة الجسم على
+
+575
+01:04:04,190 --> 01:04:08,970
+تعويض نفسه، وعلى بناء نفسه مرة أخرى، وأعضائه وأجزائه،
+
+576
+01:04:08,970 --> 01:04:16,050
+يكون من خلال الخلايا الجذعية، هناك خلايا جذعية
+
+577
+01:04:16,050 --> 01:04:26,300
+يعني، حتى الخلايا الجذعية درجات وأنواع،  الخ...  يعني إذا
+
+578
+01:04:26,300 --> 01:04:31,760
+مثلًا، واحد عنده حرق، واستطعت أن أحضر من جلده خلايا
+
+579
+01:04:31,760 --> 01:04:39,340
+جذعية جلدية التي بدأت تتخصص باتجاه الجلد، وأنا أكون
+
+580
+01:04:39,340 --> 01:04:45,660
+عنده القدرة على أن أكتشف، أو أكون قد اكتشفت، المركبات
+
+581
+01:04:45,660 --> 01:04:51,060
+الهرمونية أو الدوافع التي تجعل هذا الجلد يتكون، هذا
+
+582
+01:04:51,060 --> 01:04:59,120
+الجلد يتكاثر، هذا الجلد ينتشر، فإذا استطعت أن آخذ
+
+583
+01:04:59,120 --> 01:05:06,120
+منه وأنشطه وأستخدمه،
+
+584
+01:05:06,120 --> 01:05:10,840
+بعدين، في قضية بناء الجسم مرة ثانية، هذا من أروع
+
+585
+01:05:10,840 --> 01:05:18,870
+الأشياء، هناك، طبعًا، يعني، جزء من الموضوع أنه لماذا
+
+586
+01:05:18,870 --> 01:05:25,550
+تُدرس هذه القضايا، أحيانًا، أنه كما رأينا بهذا
+
+587
+01:05:25,550 --> 01:05:34,570
+الشكل، ورأينا الصورة من قبل، ممكن، يعني، هنا التي هي
+
+588
+01:05:34,570 --> 01:05:43,270
+كما يُقال، آليات التعامل مع الخلايا الجذعية، تكون
+
+589
+01:05:43,270 --> 01:05:53,130
+هنا، يعني، نوع من الـ suction، نوع من الـ، يعني عبارة
+
+590
+01:05:53,130 --> 01:05:59,470
+عن تفريغ هواء، بحيث أنه تُمسك القطع، يعني زي الكرة
+
+591
+01:05:59,470 --> 01:06:06,410
+العاملة، أو عنقود عنب مثلًا، نسميه، مُمسك بشكل مُثبت، وله
+
+592
+01:06:06,410 --> 01:06:15,190
+بهذه القطعة، وندخل إبرة تحت الميكروسكوب، كل هذا، نأخذ
+
+593
+01:06:15,190 --> 01:06:22,130
+عينة خلية واحدة، نأخذها وندرسها، فهذه إمكانيات
+
+594
+01:06:22,130 --> 01:06:26,530
+الخلايا الجذعية متقدمة، ويمكن
+
+595
+01:06:26,530 --> 01:06:28,490
+الاستفادة منها،
+
+596
+01:06:34,620 --> 01:06:40,440
+الاستفادة من الخلايا الجذعية في الخلايا الجسدية،
+
+597
+01:06:40,440 --> 01:06:49,020
+ماشي، يعني، بالذات، أنا ذكرت أهم جانبين، الخلايا
+
+598
+01:06:49,020 --> 01:06:53,520
+الجذعية، ممكن تستفاد منها، ولا يوجد عليها مشاكل، أو
+
+599
+01:06:53,520 --> 01:06:59,840
+مشاكل الأمراض، قضية نقل الـ Thalassemia أو الـ
+
+600
+01:06:59,840 --> 01:07:03,800
+Hemoglobinopathies، أن الواحد يعوض الجينات الخاصة بالـ
+
+601
+01:07:03,800 --> 01:07:07,860
+Hemoglobin، أو مثلًا أمراض نقص المناعة الأولية،
+
+602
+01:07:07,860 --> 01:07:13,460
+Primary Immune Deficiencies، هذه مثبتة، وليس عليها
+
+603
+01:07:13,460 --> 01:07:23,420
+مشاكل، عندما يدخل الواحد في خلايا ليست Somatic،
+
+604
+01:07:23,420 --> 01:07:30,420
+عبارة عن ناقلة للمادة الوراثية،  كما المبايض،
+
+605
+01:07:30,420 --> 01:07:42,340
+الـ Testes، الـ Embryos، بشكل مختلف، يصبح هناك
+
+606
+01:07:42,340 --> 01:07:48,060
+إشكالات أخلاقية يجب أن ينتبه إليها الواحد،  ذكرنا
+
+607
+01:07:48,060 --> 01:07:52,500
+مثالًا من قبل على استخدام الـ CRISPR، وهو  هذا
+
+608
+01:07:52,500 --> 01:07:59,220
+يتم تعديله بطريقة مختلفة، محاولة دراسة هذه النواحي مهمة
+
+609
+01:07:59,220 --> 01:08:06,080
+جدا، وله تدخل في تطور الإنسان، العلاقة عندما نكون
+
+610
+01:08:06,080 --> 01:08:11,300
+نرى
+
+611
+01:08:11,300 --> 01:08:23,710
+قضية أنّه عبارة عن، عندما يكون هناك توأم في الحمل، نسبة
+
+612
+01:08:23,710 --> 01:08:32,150
+35% يكون التوأمان
+
+613
+01:08:32,150 --> 01:08:41,870
+كل واحد منهما له كيس ماء، ويعني تطور منفصل تمامًا،
+
+614
+01:08:41,870 --> 01:08:49,070
+هذا تقريبًا نسبته 35%، وعندما  البيضة تنقسم وتصبح
+
+615
+01:08:49,070 --> 01:08:56,330
+الـ
+
+667
+01:14:26,050 --> 01:14:30,360
+الجانب يكون أحيانًا فيه repressor يعني فيه
+
+668
+01:14:30,360 --> 01:14:37,080
+inhibitors حتى أحيانًا بتكون موجودة، فالفكرة اللي
+
+669
+01:14:37,080 --> 01:14:42,840
+بدنا ناخدها أنه حتى بعد حياة الإنسان، يعني بعد
+
+670
+01:14:42,840 --> 01:14:48,660
+ولادة أي protein بتتم تنشيطه وعمله في مرحلة معينة
+
+671
+01:14:48,660 --> 01:14:57,080
+البداية راح تكون على مستوى الـDNA، البداية هتكون
+
+672
+01:14:57,080 --> 01:15:03,260
+بنظام دقيق مع عوامل كثيرة تنشط أو تثبط أو تحدد
+
+673
+01:15:03,260 --> 01:15:09,500
+القراءة، يعني أن إنتاج أي بروتين أو RNA في هذه
+
+674
+01:15:09,500 --> 01:15:16,340
+الحالة بالضبط ليس قضية عشوائية، ليست قضية ذاتية من
+
+675
+01:15:16,340 --> 01:15:23,060
+حالها، إنما هناك أوامر تحدث لأنها تطلب منها حتى تعمل
+
+676
+01:15:23,060 --> 01:15:33,220
+هذا الأمر الـ… الآن على، يعني حتى من كائنات حية زي
+
+677
+01:15:33,220 --> 01:15:43,060
+الدبابة، المنطقة الأمامية، المنطقة الـ… الـDistal،
+
+678
+01:15:43,060 --> 01:15:49,060
+Proximal، Posterior، Anterior، يعني حتى في نمو
+
+679
+01:15:49,060 --> 01:15:55,070
+الإنسان ونمو هذه الكائنات، ما هو الشيء اللي سيكون في
+
+680
+01:15:55,070 --> 01:15:57,630
+الأمام؟ ما هو الشيء اللي سيكون في الخلف؟ ما هو الـ
+
+681
+01:15:57,630 --> 01:16:00,550
+«على اليمين»؟ «على اليسار»؟ «الأقرب للمنتصف»؟
+
+682
+01:16:00,550 --> 01:16:08,090
+«الأبعد للمنتصف»؟ كل هذه هناك محددات وعوامل تنشيط
+
+683
+01:16:08,090 --> 01:16:13,950
+لتدفع الخلايا باتجاه معين، فمثل على ذلك بالنسبة
+
+684
+01:16:13,950 --> 01:16:21,450
+للعظام، يعني هنا حاطين صور اختلالات وراثية في الـ
+
+685
+01:16:21,450 --> 01:16:30,730
+Development of Bones، فهنا الـHOXD13 عبارة عن
+
+686
+01:16:30,730 --> 01:16:37,870
+مجموعة جينات وظيفتها تنشط، الله أعلم، البروتين اللي
+
+687
+01:16:37,870 --> 01:16:42,750
+بتكون مسئولة عن إنتاجه، بس خلل في هذه المناطق من
+
+688
+01:16:42,750 --> 01:16:48,810
+الـDNA يجعل هناك مشاكل، اليدين هؤلاء، ملتصقة، يعني
+
+689
+01:16:48,810 --> 01:16:55,470
+هنا الإبهام ملتصقة ببعض ولم تنفصل، لم تتطور بالشكل
+
+690
+01:16:55,470 --> 01:17:03,290
+السليم، بالنسبة للمرض اللي هو Polycystic Kidney
+
+691
+01:17:03,290 --> 01:17:13,550
+Disease، عبارة عن مرض وراثي في الكبار، X-linked Recessive
+
+692
+01:17:13,550 --> 01:17:14,210
+Recessive
+
+693
+01:17:19,510 --> 01:17:27,130
+وبيكون المشكلة الأساسية فيه أن الكلى
+
+694
+01:17:27,130 --> 01:17:32,970
+بالذات، ولكن غيرها من الأعضاء بيكون فيها حويصلات
+
+695
+01:17:32,970 --> 01:17:38,930
+فالحويصلات هذه بتتضخم بشكل يضغط على باقي أنسجة
+
+696
+01:17:38,930 --> 01:17:43,990
+الكلى بحيث يسبب فشل الكلى، الـPolycystic Kidney
+
+697
+01:17:43,990 --> 01:17:47,840
+Disease بيعمل فشل الكلى، بس لأنه الكلى كبيرة ويظل
+
+698
+01:17:47,840 --> 01:17:51,860
+يطلع الـErythropoietin فما يكونش فيه أنيميا، يعني
+
+699
+01:17:51,860 --> 01:17:58,600
+أنا من الأسئلة لطلاب الطب أو للأطباء بقول لهم إيش هو
+
+700
+01:17:58,600 --> 01:18:03,340
+إذا مريض عنده facial calloway بس دمه كويس، شوف شوف
+
+701
+01:18:03,340 --> 01:18:10,420
+طبعاً، facial calloway مزمن وليس حادث، فلازم تكون
+
+702
+01:18:10,420 --> 01:18:14,330
+الإجابة في الغالب Polycystic Kidney Disease، فالـ
+
+703
+01:18:14,330 --> 01:18:20,110
+Polycystic Kidney Disease بيكون
+
+704
+01:18:20,110 --> 01:18:26,890
+الحويصلات هذه موجودة في شرايين الدماغ، في
+
+705
+01:18:26,890 --> 01:18:33,210
+البنكرياس، في أماكن أخرى، مش بس الكلى، يعني فالآن
+
+706
+01:18:33,210 --> 01:18:37,270
+لقينا إنه فيه شيء بيسموه الـEpidermal Growth Factor
+
+707
+01:18:37,270 --> 01:18:44,670
+Receptor EGFR، ماشي، هو اللي بيكون فيه اختلال
+
+708
+01:18:44,670 --> 01:18:51,350
+وبالتالي، يعني لقينا الجين المسؤول عن هذه الظاهرة
+
+709
+01:18:51,350 --> 01:19:00,010
+فهنا جميل إن الواحد يكون قادر على من الحالة
+
+710
+01:19:00,010 --> 01:19:07,450
+بمرض بشكل معين، أرجع أعمل دراسة وراثية وجينية
+
+711
+01:19:07,450 --> 01:19:12,650
+وألاقي اختلال في جين معين، وأحاول أفسر كيف هذا
+
+712
+01:19:12,650 --> 01:19:19,670
+الأمر حصل، كذلك في قضية الحالة
+
+713
+01:19:19,670 --> 01:19:26,510
+النادر من قضية اسمها «Lysencephaly»، «Lysencephaly»
+
+714
+01:19:26,510 --> 01:19:33,030
+أو «Lysencephalitis»، دا فيه التهاب في الدماغ نفسه
+
+715
+01:19:33,030 --> 01:19:43,290
+فهنا في حاطين تفاصيل أكثر عن الأمراض، بيكون الاختلال
+
+716
+01:19:43,290 --> 01:19:48,270
+أنه قشرة
+
+717
+01:19:48,270 --> 01:19:57,270
+الدماغ بتكون بشكل، بنقول «سلس» وبنقول «عش» عنه «ملس»
+
+718
+01:19:57,270 --> 01:20:04,750
+وليس متعرج، ماشي؟ فالـ«إنسان سفلي» بيكون خلل في
+
+719
+01:20:04,750 --> 01:20:11,430
+الـ«development» تبع الخلايا العصبية، وهذه أحيانًا
+
+720
+01:20:11,430 --> 01:20:18,510
+يعني إذا رأينا كيف الإنسان بيتطور، فطبعًا
+
+721
+01:20:18,510 --> 01:20:22,450
+التطور لازم يكون، حكينا في أشياء بتوجه الخلايا
+
+722
+01:20:22,450 --> 01:20:28,470
+بتروح للجهة الأمامية البطنية أو الجهة الظهرية أو
+
+723
+01:20:28,470 --> 01:20:36,710
+الجهة الـMedial الأنسية والـ الـ الـ شو بيسموها؟
+
+724
+01:20:36,710 --> 01:20:42,900
+يعني Medial و Lateral، الـMedial اللي هي الجهة
+
+725
+01:20:42,900 --> 01:20:48,580
+الأنسية والـLateral الجهة الوحشية، يعني المتوحشة
+
+726
+01:20:48,580 --> 01:20:54,580
+بعيدة، يعني فتطور الخلايا وهجرتها باتجاه السليم
+
+727
+01:20:54,580 --> 01:20:59,760
+ترتيبها بالشكل السليم، الإنسان الطبيعي قشرة الدماغ
+
+728
+01:20:59,760 --> 01:21:04,140
+والدماغ بيكون مرتب بشكل طبقات، بيكون بهذا الشكل
+
+729
+01:21:04,140 --> 01:21:12,390
+وبهذا الترتيب، لقينا إنه فيه هرمون أو جين معين اللي
+
+730
+01:21:12,390 --> 01:21:20,130
+هو LIS1، L-I-S-1، mutation بيسبب إن الخلايا بتعرفش
+
+731
+01:21:20,130 --> 01:21:25,090
+تروح وين، فهيك بتتجعلك وبتتخربط وما بتنتقلش بالشكل
+
+732
+01:21:25,090 --> 01:21:29,730
+المنتظم السليم اللي بيعطينا النمو الطبيعي للجهاز
+
+733
+01:21:29,730 --> 01:21:37,850
+العصبي، الـLissencephaly هو حالة نتيجة اختلال
+
+734
+01:21:37,850 --> 01:21:43,290
+في هرمون أو في جين معين اللي هو «LIS1»
+
+735
+01:21:43,290 --> 01:21:47,950
+وبكون نتيجته إن الخلايا ما عرفتش كيف تهاجر، وأين
+
+736
+01:21:47,950 --> 01:21:50,950
+تهاجر، كيف تهاجر بالشكل السليم في الـ
+
+737
+01:21:50,950 --> 01:21:57,670
+Development، فهناك تفاصيل كثيرة وحالات، يعني
+
+738
+01:22:01,840 --> 01:22:09,000
+متعددة من إمكانات حدوث الاختلالات
+
+739
+01:22:09,000 --> 01:22:17,660
+التطورية والعيوب الخلقية، الـBirth Defects، فالآن
+
+740
+01:22:17,660 --> 01:22:25,140
+هناك محاولة فهم أكبر للمحددات لهجرة الخلايا أو
+
+741
+01:22:25,140 --> 01:22:30,910
+لتعامل الخلايا، وهذه بتفيدنا كما بنقول دائماً، الجانب
+
+742
+01:22:30,910 --> 01:22:37,790
+الأول في قضية معرفة فهم المرض، والقضية الثانية في
+
+743
+01:22:37,790 --> 01:22:44,630
+معرفة فهم احتمالات الأدوية واحتمالات العلاجات
+
+744
+01:22:44,630 --> 01:22:49,890
+واحتمالات معالجة الحالات المختلفة، الله يعطيكم
+
+745
+01:22:49,890 --> 01:22:51,090
+الأعافية، في أسئلة؟
+
+746
+01:23:00,010 --> 01:23:05,710
+إن شاء الله خير، ونلتقي إن شاء الله الأسبوع القادم
+
+747
+01:23:05,710 --> 01:23:10,850
+يوم الأربعاء، أنتم عندكم امتحان يوم الاثنين القادم
+
+748
+01:23:10,850 --> 01:23:15,090
+إن شاء الله، نلتقي، ومش راح تكون محاضرة جديدة بقدر
+
+749
+01:23:15,090 --> 01:23:20,650
+ما هي مراجعة استعدادية للامتحان، ماشي، الله يعطيكم
+
+750
+01:23:20,650 --> 01:23:21,430
+العافية
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/w_288b1_4WQ_postprocess.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/w_288b1_4WQ_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..6d392a2b5afc310cba27bc8aa6907474f87c5a88
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/w_288b1_4WQ_postprocess.srt
@@ -0,0 +1,3001 @@
+1
+00:00:00,000 --> 00:00:05,920
+الجميع من دخل معانا في المحاضرة ووفقكم الله
+
+2
+00:00:05,920 --> 00:00:09,040
+بالنسبة
+
+3
+00:00:09,040 --> 00:00:13,020
+إن أول المحاضرة دايماً اللي في حد عنده سؤال عن
+
+4
+00:00:13,020 --> 00:00:19,780
+مواضيع السابقة مواضيع الامتحان ومش امتحان وشو
+
+5
+00:00:19,780 --> 00:00:25,600
+بنسوه المرات الجاية عند الدكتور أحمد للشباب
+
+6
+00:00:25,600 --> 00:00:30,590
+والدكتورات اللي موجودينإذا حد عنده أسئلة في
+
+7
+00:00:30,590 --> 00:00:35,390
+الوراثة إذا
+
+8
+00:00:35,390 --> 00:00:40,190
+في حد عنده سؤال ممكن نبدأ نشرحه يعني دائما الأسئلة
+
+9
+00:00:40,190 --> 00:00:47,190
+جيدة وبيشرح الواحد فيها في نقطة بشكل بتبتة عند
+
+10
+00:00:47,190 --> 00:00:52,250
+الواحد اليوم
+
+11
+00:00:57,360 --> 00:01:04,440
+فاحنا نتكلم إن شاء الله عن موضوع آخر ماشي،
+
+12
+00:01:04,440 --> 00:01:12,400
+كأنه فيه سؤال كرمل؟
+
+13
+00:01:12,400 --> 00:01:16,100
+طيب
+
+14
+00:01:16,100 --> 00:01:22,900
+بالنسبة لقضية الـ Human أو الـ Developmental
+
+15
+00:01:22,900 --> 00:01:24,740
+Genetics أنبعاث التفكير
+
+16
+00:01:28,040 --> 00:01:33,340
+يعني هذا موضوع يعني
+
+17
+00:01:33,340 --> 00:01:42,420
+شغل الأولماء وهناك يعني جوانب
+
+18
+00:01:42,420 --> 00:01:49,900
+في تطور الإنسان وخلق الإنسان وبعد ذلك حدوث
+
+19
+00:01:49,900 --> 00:02:00,190
+اختلالات معينة بشكليعني بانقسام غريب مهير للإنتباه
+
+20
+00:02:00,190 --> 00:02:09,330
+وهذه يعني يتم دراستها في عالمة مصرية في الخمسينات
+
+21
+00:02:09,330 --> 00:02:15,790
+والستينات من أقوى من قام بدراسة الاختلالات
+
+22
+00:02:15,790 --> 00:02:24,690
+التطورية في ذات الإيدين والرجلين وطريقةالاختلال
+
+23
+00:02:24,690 --> 00:02:32,110
+أنا يعني إذا بدي إشي من هالصورة اللي قدامنا بديش
+
+24
+00:02:32,110 --> 00:02:32,430
+اسم
+
+25
+00:02:32,430 --> 00:02:48,890
+الـ’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’
+
+26
+00:02:49,710 --> 00:02:56,890
+تخيل أو متباهة
+
+27
+00:02:56,890 --> 00:03:02,230
+لقضية ما يحصل أو ما هو الخلل هنا أو ما يسميها
+
+28
+00:03:02,230 --> 00:03:07,490
+فالطفل هذا اللي عنده سبع أصابع هذا اسمه
+
+29
+00:03:07,490 --> 00:03:13,770
+polydactyly axial polydactyly poly يعني أكتر،
+
+30
+00:03:13,770 --> 00:03:22,960
+dactyly اللي هي يعني قضية الأصابعماشي و «severe
+
+31
+00:03:22,960 --> 00:03:28,960
+cutaneous syndectomy» «سن» يعني مجموع مع بعضه
+
+32
+00:03:28,960 --> 00:03:32,200
+فالأصابع
+
+33
+00:03:32,200 --> 00:03:40,860
+بشكل جلدي مجموعات على بعض وفي اختلال في تطور هذا
+
+34
+00:03:40,860 --> 00:03:47,200
+الجنين وهذا الإنسان إنه الأصابع ماكنتش بالشكل
+
+35
+00:03:47,200 --> 00:03:55,570
+المفصول اللي احنا نتوقعهفهذه اختلالات تطورية وهذه
+
+36
+00:03:55,570 --> 00:04:04,510
+يعني اكتشفنا بعدين إنه الجينات والعوامل الوراثية
+
+37
+00:04:04,510 --> 00:04:13,670
+بتكون بتتحكم بهذا الأمر فقضية إنه يعني معرفة هذه
+
+38
+00:04:13,670 --> 00:04:22,160
+الجينات وسببهافي حدوث هذا المظهر، هذا الشكل دورها
+
+39
+00:04:22,160 --> 00:04:27,460
+يعني في قضية تطور الأطراف، تطور الأصابع، تطور
+
+40
+00:04:27,460 --> 00:04:35,380
+الحلق، التم، الدنين، الرجلين، التطور أي جانب قضية
+
+41
+00:04:35,380 --> 00:04:40,920
+بدها دراسة وبدالواحد يكون على اقتلاعها فهنا طبعاً
+
+42
+00:04:42,810 --> 00:04:49,830
+يعني كلمة أسماء نفس
+
+43
+00:04:49,830 --> 00:04:56,950
+الـSyndromes بحد ذاتهم ماشي ما أظن يعني حتى ولو في
+
+44
+00:04:56,950 --> 00:05:02,370
+الـUS أملي أو في غيرها من الأسئلة بهمهم الواحد
+
+45
+00:05:02,370 --> 00:05:09,030
+يعني بحد ذاته اسم المرض بقدر ما أنه كمان الواحد
+
+46
+00:05:09,030 --> 00:05:16,200
+يعني يستخدم الاسم هذابتذكر مجموعة الأعراض
+
+47
+00:05:16,200 --> 00:05:20,680
+الموجودة كيف بتكون وهم ذلك بالذات الأشياء اللي
+
+48
+00:05:20,680 --> 00:05:28,720
+فيها تبت أمور جينية ورافية أنه الواحد يشوف شو الـ…
+
+49
+00:05:28,720 --> 00:05:35,800
+الـMutation وين موجودة في أي جين وليش بيعمل هذا
+
+50
+00:05:35,800 --> 00:05:40,600
+الاشي والقضايا هذه الـ
+
+51
+00:05:41,110 --> 00:05:48,090
+هنا إشي اسمه يعني congenital arthrogyropsis
+
+52
+00:06:28,550 --> 00:06:35,130
+السلام عليكم، شكله انقطع، ما أعرف، فالحال
+
+53
+00:06:35,130 --> 00:06:40,350
+هنا اللي
+
+54
+00:06:40,350 --> 00:06:49,010
+بيفرجونيا بالنسبة للصورة
+
+55
+00:06:49,010 --> 00:06:51,870
+الحديث الولاد هذا الـ Newborn هذا
+
+56
+00:06:54,730 --> 00:06:59,230
+دكتور، بعد ذلك بستعمل share للشاشة اللي ليه مش
+
+57
+00:06:59,230 --> 00:07:11,490
+مبينة أه أه أه، لأنه ما طلعني أهي، أين راحت؟
+
+58
+00:07:27,960 --> 00:07:35,380
+بقول هنا في صورة يعني
+
+59
+00:07:35,380 --> 00:07:43,060
+still birth يعني ولادة جنين ميت الاختلالات
+
+60
+00:07:43,060 --> 00:07:52,080
+الموجودة إنه كان الحمل حوالين الجنين السائل
+
+61
+00:07:52,080 --> 00:07:57,660
+الأمنيوثي أو الـ Ammoniotic Fluid كان قليل جداً
+
+62
+00:07:58,130 --> 00:08:05,930
+وكمان نتيجة اختلال في العضلات أصبح هناك شد شديد
+
+63
+00:08:05,930 --> 00:08:14,930
+وعدم فاعلية في … عدم
+
+64
+00:08:14,930 --> 00:08:22,350
+فاعلية بالنسبة للعضلات وبالتالي المفاصل كانت
+
+65
+00:08:22,350 --> 00:08:28,070
+يعني مضروبة بشكلزي هيك يعني الإيد مش مفتوحة الرجل
+
+66
+00:08:28,070 --> 00:08:34,850
+مش مفتوحة والشكل هذا هنا يعني قضية إنه مايكنش فيه
+
+67
+00:08:34,850 --> 00:08:42,710
+سائل حوالين الجنين أحيانًا بيكون نتيجة مشاكل في
+
+68
+00:08:42,710 --> 00:08:47,710
+الـ يعني غالبية السائل اللي حوالين الحمل هو من الـ
+
+69
+00:08:47,710 --> 00:08:51,350
+ball تبع نفس الجنين يعني بالإضاءة للإفرازات
+
+70
+00:08:51,350 --> 00:08:57,550
+المشيمة أو أشياء تانيةفلما ما يكونش موجود أحيانًا
+
+71
+00:08:57,550 --> 00:09:04,330
+بيكون مؤشر على مثلًا فشل كلوي في الجنين، عدم
+
+72
+00:09:04,330 --> 00:09:10,750
+إمكانية إفراز البول، وده ولد بشكل طبيعي، يعني
+
+73
+00:09:10,750 --> 00:09:18,710
+قدرنا يوصل لحد أن يكون بعد ذلك يولد بشكل طبيعي، هو
+
+74
+00:09:18,710 --> 00:09:25,720
+نحطي ملاحظة على الحالة هذهإنه في هذه الحالة الدكاء
+
+75
+00:09:25,720 --> 00:09:32,120
+والتطور العقلي العصبي كان طبيعي وإنه بس بده شغل
+
+76
+00:09:32,120 --> 00:09:39,740
+على عمليات وبالنسبة لعلاج
+
+77
+00:09:39,740 --> 00:09:49,180
+طبيعي للجوانب العظام يعني فلما نلاقي الإنسان عنده
+
+78
+00:09:51,700 --> 00:09:59,880
+يعني مشاكل الجانب الأهم لقضية إنه هل هذا مشكلة
+
+79
+00:09:59,880 --> 00:10:05,080
+ويراثية ولا لأ لما نجد الإنسان حالة أو عائلة بمثل
+
+80
+00:10:05,080 --> 00:10:12,080
+هذا الشكل بنتبه إن الحالة الوراثية بدي تكون أكثر
+
+81
+00:10:12,080 --> 00:10:15,900
+من فرد في العائلة مصاب يعني إن هذه شغل الواحد بده
+
+82
+00:10:15,900 --> 00:10:24,740
+يدور عليها أو يشوفهاوبدّو يحاول يعني ينتبه لها
+
+83
+00:10:24,740 --> 00:10:27,820
+فأنا
+
+84
+00:10:27,820 --> 00:10:38,680
+بحاول أن أنزل هنا
+
+85
+00:10:38,680 --> 00:10:47,160
+في أحيانًا أحداث يعني أنا بظن بعد ذلك
+
+86
+00:10:51,080 --> 00:11:01,260
+بيحاولوا يتكلموا عنها أنه لما نشوف حالات وراثية أو
+
+87
+00:11:01,260 --> 00:11:08,340
+يعني اللي هي أكتر من فرد في العائلة ونحاول
+
+88
+00:11:08,340 --> 00:11:17,980
+نشوف الأمراض الناتجة عنهاسواء في عائلة معينة أو في
+
+89
+00:11:17,980 --> 00:11:27,460
+مجتمع نجي نعمل دراسة بنلاقي إنه 20% تقريبًا بيكون
+
+90
+00:11:27,460 --> 00:11:33,400
+سببها Single-Gene Defect يعني هذه اللي هي من
+
+91
+00:11:33,400 --> 00:11:39,200
+المسببات للـ Developmental Malformations الـ
+
+92
+00:11:39,200 --> 00:11:48,460
+Developmental Anomalies بنلاقي إنهإن يكون سببها
+
+93
+00:11:48,460 --> 00:11:54,940
+فقط جين واحد هذا بيكون تقريبًا بنسبة عشرين بالمية
+
+94
+00:11:54,940 --> 00:12:05,780
+تقريبًا أحيانًا في هناك اختلالات تراثية أخرى زي
+
+95
+00:12:05,780 --> 00:12:11,880
+copy number variants في جين معين مش شغلة Mendelian
+
+96
+00:12:11,880 --> 00:12:16,410
+inheritanceالـ Copy مضروبة أو الـ Copy طبيعية
+والـ
+
+97
+00:12:16,410 --> 00:12:20,910
+Copy المضروبة هي اللي أعطت المرض، لأ بيكون حالات
+
+98
+00:12:20,910 --> 00:12:26,010
+أخرى مجموعة من الـ يعني وفي صورة عنها حتى جزء منها
+
+99
+00:12:26,010 --> 00:12:31,770
+موجود في الكائنات الأخرى مثلًا وانا راح اتكلم عنها
+
+100
+00:12:31,770 --> 00:12:37,610
+ببابة الـ Drosophila أو غيرها أو كده ففي مرات وجود
+
+101
+00:12:37,610 --> 00:12:43,300
+أكتر منالنسخة أو عدد النسخ الموجودة بالنسبة لجين
+
+102
+00:12:43,300 --> 00:12:49,780
+معين فيه هناك أحيانًا 25% كروموزوم الـ anomalies
+
+103
+00:12:49,780 --> 00:12:55,860
+فهذه تتكلم تقريبًا الواحد على ربع الحالات ويكون
+
+104
+00:12:55,860 --> 00:13:02,120
+على مستوى قطعة كبيرة من الـDNA فالكروموزوم بأكمله
+
+105
+00:13:02,120 --> 00:13:07,200
+ممكن يكون فيه اختلال وممكن قطعة كبيرة في
+
+106
+00:13:07,200 --> 00:13:13,700
+الكروموزومزي ما حكينا مرات في بعض الحالات بتكون
+
+107
+00:13:13,700 --> 00:13:19,760
+باند كبير، خطعة كبيرة يعني بتكون فيها عدد كبير من
+
+108
+00:13:19,760 --> 00:13:28,620
+الجينات مش جين واحد 5% تيراتوجين تيراتو يعني مسبب
+
+109
+00:13:28,620 --> 00:13:33,280
+للمشاكل
+
+110
+00:13:33,280 --> 00:13:37,400
+التطورية
+
+111
+00:13:37,930 --> 00:13:46,270
+ماشي، اللي هي مثلًا أشهر قصة تتذكروا بالنسبة لشغل
+
+112
+00:13:46,270 --> 00:13:52,730
+Teratogen دوة اسمها «الثالودامايد» «الثالودامايد»
+
+113
+00:13:52,730 --> 00:14:00,230
+عبارة عن في الخمسينات حتى في أمريكا مبسوطين إن
+
+114
+00:14:00,230 --> 00:14:07,010
+وكالة الدواء والغذاء منعت دخوله من أوروبا لأمريكا
+
+115
+00:14:08,100 --> 00:14:15,420
+فهو عبارة عن دوة مخفف لأعراض الغثيان والاستفراج
+
+116
+00:14:15,420 --> 00:14:21,340
+وخصوصاً الحوامل يعني معروف الحوامل بيجي عندهم
+
+117
+00:14:21,340 --> 00:14:25,540
+غثيان واستفراج وبعضاً في أول الحمل وبعضاً في أوسطه
+
+118
+00:14:25,540 --> 00:14:31,460
+وبعضاً ويلها هاي أسباب كثيرة فالـ Thalidomide دوة
+
+119
+00:14:31,460 --> 00:14:38,620
+أصبح بالذات في أوروبا لقضية غثيان الحوامل دوةكثير
+
+120
+00:14:38,620 --> 00:14:44,480
+الانتشار نتيجة استخدام هذا الدواء هناك نسبة عالية
+
+121
+00:14:44,480 --> 00:14:53,200
+أو نسبة محترمة من وجود ولود أو ولادة أو تخلق أطفال
+
+122
+00:14:53,200 --> 00:14:59,580
+بغير أطرافه، ناشي؟ يعني مافيش إيدين، مافيش رجلين
+
+123
+00:14:59,580 --> 00:15:05,600
+الأربعة، تلاتة، اتنين، يعني التطوراتيعني الـ
+
+124
+00:15:05,600 --> 00:15:10,920
+Congenital Defect كبير جدًا كان
+
+125
+00:15:10,920 --> 00:15:17,780
+هناك بنقصين وباء من قضية ولادة أطفال مشوهين بلا
+
+126
+00:15:17,780 --> 00:15:22,140
+أطراف فثبت بعدين إن هذا هو الـ Thalidomide كان
+
+127
+00:15:22,140 --> 00:15:31,820
+السبب ليش وكيف وكذا كانت
+
+128
+00:15:31,820 --> 00:15:37,440
+تجربة سيئة في العالم ومنعالآن الـ Thalidomide هو
+
+129
+00:15:37,440 --> 00:15:47,420
+دوة حكينا أنه قوى جداً وكويس ضد الغثيان والاستفراغ
+
+130
+00:15:47,420 --> 00:15:53,760
+والعيان وهو مظاهر مزعجة جداً وهو فعال جداً، فالآن
+
+131
+00:15:53,760 --> 00:16:00,950
+في حالات قليلة منمثلًا حالات متقدمة من السلطان
+
+132
+00:16:00,950 --> 00:16:07,370
+وفيها رثيان واستفرار في بعض الحالات الأخرى للأن
+
+133
+00:16:07,370 --> 00:16:14,670
+يُستخدم فالـ Thalidomide هو الـ «تيراتوجين» وإله
+
+134
+00:16:14,670 --> 00:16:19,770
+قصته ويعني أنا أظن أنه حتى يعني في الثقافة العامة
+
+135
+00:16:19,770 --> 00:16:26,720
+عند الناس يعني بالذات أول الحمل الأصلمرة الحامل ما
+
+136
+00:16:26,720 --> 00:16:31,280
+تأخذ أدوية ويحاول الواحد يبعد عن الأدوية إلا إذا
+
+137
+00:16:31,280 --> 00:16:35,300
+فيه ضرورة لهذا الدواء من ناحية ومن ناحية ثانية
+
+138
+00:16:35,300 --> 00:16:45,040
+يكون هذا الدواء مثبت أنه بشكل مفيد يعني
+
+139
+00:16:45,040 --> 00:16:48,740
+من الجوانب اللي يجب تكون معروفة عند الواحد أن
+
+140
+00:16:48,740 --> 00:16:57,140
+الأدوية بالنسبة للحمليُقال عنها A وB وC Class A
+
+141
+00:16:57,140 --> 00:17:06,380
+وClass B وClass C Class A هو دوة ثبت أمنه وثبت
+
+142
+00:17:06,380 --> 00:17:13,140
+فائدته يعني إنه لا يسبب أي تأثير سلبي على الحمل
+
+143
+00:17:13,140 --> 00:17:22,570
+Class C يعني ممنوع وثبت إنه مضر Class Bاللي بالنص
+
+144
+00:17:22,570 --> 00:17:27,070
+يعني اللي يقولها بيقولّه «أه و لا لأ» يعني it
+
+145
+00:17:27,070 --> 00:17:34,630
+wasn't proven teratogenic و dangerous و ممنوع ولا
+
+146
+00:17:34,630 --> 00:17:40,670
+ثبت أنه آمن و كويس هذه بيقولّك أنت كطبيب مع
+
+147
+00:17:40,670 --> 00:17:50,090
+المريضة بتتناقشوا، بتقدروا حسب درجة خطورة و إزعاج
+
+148
+00:17:51,070 --> 00:17:56,170
+التأثير العرض والمرض عليه للمريضة بنعطي الدواء أو
+
+149
+00:17:56,170 --> 00:18:06,090
+بالبطلة فهي النقطة الأساسية إنه أكثر من يعني فيه
+
+150
+00:18:06,090 --> 00:18:17,210
+هناك حوالي 40% عبارة عن تداخل حالات وأوضاع وراثية
+
+151
+00:18:17,210 --> 00:18:24,480
+Single gene أو Teratogenأو أكثر من خلل في نفس
+
+152
+00:18:24,480 --> 00:18:34,620
+الوقت فإحنا اللي بنلاحظ هنا إنه تقريبًا يعني أكثر
+
+153
+00:18:34,620 --> 00:18:43,560
+من النصف، يعني نتكلم على بعض، 35، 20، 55% إبارة عن
+
+154
+00:18:43,560 --> 00:18:53,980
+حالات Genetic، حالات ورافيةبطرق مختلفة وبتكون هناك
+
+155
+00:18:53,980 --> 00:19:02,460
+إشكاليات من الـMultifactorial قضية اللي حكينا عنها
+
+156
+00:19:02,460 --> 00:19:06,860
+مرة جيبنا عرض عنها اللي هي تعويض الـFolic Acid عند
+
+157
+00:19:06,860 --> 00:19:13,920
+الحوامل حيث أنه نقص الـFolic Acid بسبب ما يسمونه
+
+158
+00:19:13,920 --> 00:19:19,760
+الـNeuronal Tube Defect عبارة عن اختلالات فيلتطور
+
+159
+00:19:19,760 --> 00:19:23,840
+الجهاز العصبي بشكل معين ويصير في حالة بنسميها
+
+160
+00:19:23,840 --> 00:19:31,700
+«Spina Bifida» يعني أنه فتحة في الحبل الشوكي بحيث
+
+161
+00:19:31,700 --> 00:19:36,860
+أنه ما بيسكر بالشكل السليم وبالتالي، تطور الأعصاب
+
+162
+00:19:36,860 --> 00:19:44,380
+بيكون بشكل مضروب وممكن يعني إيه درجات، منها الخفيف
+
+163
+00:19:44,380 --> 00:19:49,170
+كثير اللي يلاقي كاد يختلف عنالإنسان الطبيعي وفي
+
+164
+00:19:49,170 --> 00:19:56,530
+حالات أخرى بتكون شديدة كثيرًا يعني شلال نصف الجسم
+
+165
+00:19:56,530 --> 00:20:04,210
+السفلي مثلًا بتكون كاملة يعني الفكرة من المحاضرة
+
+166
+00:20:04,210 --> 00:20:13,010
+اليوم بقول إن أنا أود أتذكر هذا الشريحة
+
+167
+00:20:13,010 --> 00:20:18,640
+وقضية إنهحوالي الخمس هي single gene defect
+
+168
+00:20:18,640 --> 00:20:25,680
+بالأشياء اللي بنشوفها other forms of genetic
+
+169
+00:20:25,680 --> 00:20:30,800
+anomalies زي copy number of certain chromosome
+
+170
+00:20:30,800 --> 00:20:36,360
+variant أو copy number of certain gene variants
+
+171
+00:20:36,780 --> 00:20:41,220
+حوالي 10% على مستوى الـChromosome أنماليز تقريبًا
+
+172
+00:20:41,220 --> 00:20:48,220
+25% والبقية تيراتوجين واضح، External، مش شغل
+
+173
+00:20:48,220 --> 00:20:52,880
+الـGenetic أو يعني الـPure، Non-Genetic Cause
+
+174
+00:20:52,880 --> 00:20:57,460
+حوالي 5% كتيراتوجين بدنا نسميه والبقية هي
+
+175
+00:20:57,460 --> 00:21:00,180
+Interaction between more than one thing ممكن
+
+176
+00:21:00,180 --> 00:21:05,930
+Environmental مع الـGenetic بشكل يعنيالـMore
+
+177
+00:21:05,930 --> 00:21:14,570
+Dilute، الـ «55% التسبب الوراثي قوي وواضح» معاها
+
+178
+00:21:14,570 --> 00:21:22,110
+فمن الأشياء اللي بنشوفها يعني ظواهر أحيانًا يعني
+
+179
+00:21:22,110 --> 00:21:27,990
+كلمة «congenital» وإلى دخل بالـ «development» ماشي
+
+180
+00:21:28,470 --> 00:21:34,450
+بيكون الأشياء اللي تحدث في الـ fetal period الـ
+
+181
+00:21:34,450 --> 00:21:38,630
+embryonic period الـ embryonic بالأول الـ embryo
+
+182
+00:21:38,630 --> 00:21:44,650
+وبعدين الـ fetus بتصير فأحيانًا مثلًا الـ amniotic
+
+183
+00:21:44,650 --> 00:21:49,590
+bands يعني الـ development بتكون بطريقة مش سليمة
+
+184
+00:21:49,590 --> 00:21:54,110
+بحيث أنه شغلي مثلًا الحبل
+
+185
+00:21:59,370 --> 00:22:07,090
+ممكن يعمل مشكلة الـ Ammoniac Band هنا يعني عبارة
+
+186
+00:22:07,090 --> 00:22:15,550
+عن Band ممكن تقطع جزء من الأطراف،
+
+187
+00:22:15,550 --> 00:22:22,370
+تقطع من الـ هنا مثلا، Band واضحة اللي هي ملسقة
+
+188
+00:22:22,370 --> 00:22:28,560
+أصبعين على بعضوفي الجهة الأخرى قصة الـ
+
+189
+00:22:28,560 --> 00:22:37,280
+«development» تبع الـ «thumb»، الإبهام فحتى
+
+190
+00:22:37,280 --> 00:22:43,100
+الـ «fourth digit amputated distally» ماشي وعليها
+
+191
+00:22:43,100 --> 00:22:48,960
+«amniotic membrane» يعني مجزرة فهي أحيانًا يعني
+
+192
+00:22:48,960 --> 00:22:57,590
+دواهر يعني كلمة «amniotic» قصدتلما نقول
+
+193
+00:22:57,590 --> 00:23:02,150
+«congenital» أحيانًا يعني مش بالضرورة يعني أحيانًا
+
+194
+00:23:02,150 --> 00:23:06,270
+نقول «congenital anomaly» لأنها تحدث، بتبين خلال
+
+195
+00:23:06,270 --> 00:23:15,130
+الحمل والقضية هنا إنه ممكن يكون هذه أشياء عبارة عن
+
+196
+00:23:15,130 --> 00:23:23,830
+أشياء بيئية يعني مثلًا يعني أسا مثلًا الذكاء
+
+197
+00:23:24,570 --> 00:23:28,890
+الزيكا، زيكا بايروس، سادة المفروض تكونوا عارفين
+
+198
+00:23:28,890 --> 00:23:34,110
+عنه ممكن يجيكم حتى في الأسئلة و لا كده زيكا عبارة
+
+199
+00:23:34,110 --> 00:23:44,710
+عن مرض فيروسي بينتقل عن طريق فرصة البعوض يعني زي
+
+200
+00:23:44,710 --> 00:23:50,830
+حمض ضنك اللي هي الـ Dingo fever الـ Zika عبارة عن
+
+201
+00:23:50,830 --> 00:23:52,090
+قبل
+
+202
+00:23:53,990 --> 00:23:59,450
+قبل الـ «كورونا» يعني قبلها خمس سنين كان الـ
+
+203
+00:23:59,450 --> 00:24:07,230
+«زيكا» هو اللي عامل يعني رعب في العالم والسبب إنه
+
+204
+00:24:07,230 --> 00:24:12,850
+إذا المرأة الحامل صابها، شو بيصير فيه؟ حد بعرف؟
+
+205
+00:24:12,850 --> 00:24:19,350
+عشان أشوف صحين معاي ولا عندكم إشي؟ شو بعمل الـ
+
+206
+00:24:19,350 --> 00:24:26,670
+«زيكا»؟ألماذة، إيمان، كريم، آيو كريم، كرمل حد
+
+207
+00:24:26,670 --> 00:24:32,890
+بيعرف شو بعمل الذيكا يعني إذا أنتوا بتتابعوا
+
+208
+00:24:32,890 --> 00:24:38,270
+الأيام هذه بالذات من البلاد المضروبة بوباء
+
+209
+00:24:38,270 --> 00:24:42,570
+الكورونا في أمريكا وفيهم عالم مشهور اسمه Antony
+
+210
+00:24:42,570 --> 00:24:43,170
+Fauci
+
+211
+00:24:46,160 --> 00:24:50,920
+يعني هو المستشار للرؤوساء الأمريكان مستشار الصحي
+
+212
+00:24:50,920 --> 00:24:57,400
+للرؤوساء الأمريكان من عهد Reagan يعني بيقول نصحت
+
+213
+00:24:57,400 --> 00:25:02,680
+ست رؤوساء أمريكية أنه اللي غلبوا بس هو الـTrump من
+
+214
+00:25:02,680 --> 00:25:09,720
+أيام الـHIV والـAIDS والـepidemic وكل كده فبالنسبة
+
+215
+00:25:09,720 --> 00:25:13,900
+له كام من المشاكل اللي اتعامل معها هو الذيكا فشو
+
+216
+00:25:13,900 --> 00:25:23,050
+بيعمل الـVirus الذيكا؟إذا حد بيعرف يمكن ما يتابعوش
+
+217
+00:25:23,050 --> 00:25:31,930
+جرايد وكذا بيعمل إنه ضمور الدماغ يعني بيخلّي
+
+218
+00:25:31,930 --> 00:25:37,690
+فبالبرازيل بالذات في منطقة البرازيل أجت عندهم وباء
+
+219
+00:25:37,690 --> 00:25:44,960
+من إن الأطفال بيطلعوا روصهم صغاروعندهم تخلف عقلي
+
+220
+00:25:44,960 --> 00:25:50,400
+وعندهم مشكلة في الذكاء وفي النمو العصبي والعقلي
+
+221
+00:25:50,400 --> 00:25:57,260
+يعني فالـ Zika ثبت إنه عبارة عن فيروس في الأول
+
+222
+00:25:57,260 --> 00:26:05,050
+للحملإذا قرصت الحامل الدنيا حرّه بهالليل والبعوض
+
+223
+00:26:05,050 --> 00:26:11,330
+كثير وقرصت بالفيروس هذا بنتج عنه إن حجم الدماغ
+
+224
+00:26:11,330 --> 00:26:22,690
+بيطلع صغير وبيطلع الطفل مشوّه بطريقة ما فالنقطة
+
+225
+00:26:22,690 --> 00:26:30,730
+اللي بدنا نوصلها إنهالعوامل البيئية سواء من ناحية
+
+226
+00:26:30,730 --> 00:26:36,210
+التغذية سواء من ناحية الالتهابات يعني في الـ
+
+227
+00:26:36,210 --> 00:26:44,390
+«روبيلا» اللي فيه بيسموه مثلا من أسباب حتى
+
+228
+00:26:44,390 --> 00:26:49,610
+الإجهاض المبكر أو وفاة الجنين وكذا بيسموه
+
+229
+00:26:49,610 --> 00:26:57,090
+«التورتش» اللي هي «Trichomonas Rubella»يعني مجموعة
+
+230
+00:26:57,090 --> 00:27:03,830
+فيروسات على بكتيريا تُكسب لازموسس اللي هو نوع من
+
+231
+00:27:03,830 --> 00:27:15,410
+الطفيليات حتى فهناك أسباب كثيرة لحدوث مشاكل خلقية
+
+232
+00:27:15,410 --> 00:27:21,030
+بين قلصين أحنا بنترجمهايعني حدوثها خلال التخلق
+
+233
+00:27:21,030 --> 00:27:27,830
+اللي هي congenital بس يعني حقيقة الأسباب متعددة
+
+234
+00:27:27,830 --> 00:27:33,350
+والأسباب أحيانًا ورافية بنسبة كبيرة بس كمان بيئية
+
+235
+00:27:33,350 --> 00:27:38,330
+بنسبة مقاربة تقريبًا بس أقل شوية يعني هنا البيئية
+
+236
+00:27:38,330 --> 00:27:46,360
+تقريبًا تيجي 45 الورافية بشكل أو الجينية بشكل55%
+
+237
+00:27:46,360 --> 00:27:54,700
+على أقل على كلام دراسة معينة أحيانًا
+
+238
+00:27:54,700 --> 00:28:02,500
+يعني أنا الحالات هذه ما قريت قديش مسبب حدوثها
+
+239
+00:28:02,500 --> 00:28:12,800
+فبنتبه الواحد للأطفال اللي بيجوا وبشوف كام يعني
+
+240
+00:28:12,800 --> 00:28:13,320
+كام
+
+241
+00:28:15,860 --> 00:28:22,900
+ووجود مجموعة الظواهر
+
+242
+00:28:22,900 --> 00:28:27,480
+أو الأعراض أو الـ «symptoms» و«signs» الأعراض
+
+243
+00:28:27,480 --> 00:28:34,280
+والعلامات اللي بنشوفها يعني أحيانًا بنتبه الواحد
+
+244
+00:28:34,280 --> 00:28:38,480
+إنه تقريبًا أنا ممكن كان شُفت حالة زي هيك أو إنسان
+
+245
+00:28:38,480 --> 00:28:45,620
+شكله زي هيكهنا أسئلة اسمها «ربينشتاين تايبي
+
+246
+00:28:45,620 --> 00:28:54,380
+سندروم» إبارة عن تخلف عقلي أو تخلف مش عقلي فقط
+
+247
+00:28:54,380 --> 00:29:06,340
+وإنما تخلف أو تأخر، تطوري فبتلاقي الأطفال المصابين
+
+248
+00:29:06,340 --> 00:29:14,490
+إلهم هنا وجهبشكل معين يعني Distinctive facial
+
+249
+00:29:14,490 --> 00:29:19,750
+appearance الأصابع والأبافر أو الأيدين يعني هيك
+
+250
+00:29:19,750 --> 00:29:28,490
+عريضات بشكل أكبر من المتوقع يعني Large toes ومشاكل
+
+251
+00:29:28,490 --> 00:29:32,450
+في القلب فالجميل
+
+252
+00:29:32,450 --> 00:29:37,970
+يعني لما نكون عند واحد عائلة وليش سموها بهذا الإسم
+
+253
+00:29:37,970 --> 00:29:42,450
+اللي هم هذول اتنيناللي اشتركوا «روفنشتاين» وType B
+
+254
+00:29:42,450 --> 00:29:47,330
+Syndrome أنا بتوقع على الأقل الـMajor Things اللي
+
+255
+00:29:47,330 --> 00:29:53,750
+أنتوا بتشوفوها وجابيلكم إياها مش غلط الواحد يقرأ
+
+256
+00:29:53,750 --> 00:29:58,330
+عنها وعلى الأقل بتعطي الواحد هيك حصيلة جيدة من
+
+257
+00:29:58,330 --> 00:30:03,530
+أسماء أنواع المشاكل الـ
+
+258
+00:30:06,740 --> 00:30:13,200
+لأ، اللي كان دور العالمين هذولة في .. يعني ليش
+
+259
+00:30:13,200 --> 00:30:17,820
+حطوا الإسم باسمهم جزء من الموضوع يمكن بيكونوا هم
+
+260
+00:30:17,820 --> 00:30:24,500
+أول ناس لقوا عائلة أو درسوها أو بيحاولوا يدرسوا شو
+
+261
+00:30:24,500 --> 00:30:36,120
+المسبب فالـ .. هنا القيلة إن الموضوععبارة عن خسارة
+
+262
+00:30:36,120 --> 00:30:45,540
+وظيفة جينات أثنان بشكل قريبين
+
+263
+00:30:45,540 --> 00:30:52,360
+جداً على بعض عبارة عن الـ Closely Related
+
+264
+00:30:52,360 --> 00:30:59,180
+Transcriptional Coactivators Transcriptionيعني
+
+265
+00:30:59,180 --> 00:31:06,280
+لموضوع عملية تحويل الـ «DNA» إلى الـ «RNA» يعني
+
+266
+00:31:06,280 --> 00:31:13,720
+نقل وقراءة خط الـ «DNA» واستخلاص المادة الوراثية
+
+267
+00:31:13,720 --> 00:31:18,720
+منه لتحويلها إلى الـ «RNA» حتى نطلع منها الـ
+
+268
+00:31:18,720 --> 00:31:26,920
+«بروتين» ففيه «coactive headers» معينةCBP يعني
+
+269
+00:31:26,920 --> 00:31:37,280
+عصاي لفوق وبعدين B لتحت عصاي لتحت أو EP300 فهذه
+
+270
+00:31:37,280 --> 00:31:40,920
+الطريقة
+
+271
+00:31:40,920 --> 00:31:45,320
+وهذه الظواهر
+
+272
+00:31:45,320 --> 00:31:51,640
+ما هي علاقتها بشكل مباشر فيهذا الـ «جين» بهذه
+
+273
+00:31:51,640 --> 00:31:57,560
+الطريقة بتكون لسه من الأسرار اللي ربنا بيمتلكها
+
+274
+00:31:57,560 --> 00:32:03,460
+وكل ما يكتشف الواحد أشياء بيكتشف اللي لسه مش عارف
+
+275
+00:32:03,460 --> 00:32:10,860
+أحيانًا المظهر اللي احنا بنشوفه هو نتيجة خلل في
+
+276
+00:32:10,860 --> 00:32:18,210
+جانب معين وزي ما انتم لاحظين قضية أنهالوجه،
+
+277
+00:32:18,210 --> 00:32:23,370
+الأطراف، القلب يعني مأثر على كذا محل في جسم
+
+278
+00:32:23,370 --> 00:32:29,090
+الإنسان والنمو مش طبيعي هناك
+
+279
+00:32:29,090 --> 00:32:38,970
+يعني بواهر يعني النقطة
+
+280
+00:32:38,970 --> 00:32:44,870
+اللي بحكوها بالنسبة للي حطيناها قبل شويةكان قدرنا
+
+281
+00:32:44,870 --> 00:32:51,370
+نصل إلى إن هوين الجين اللي عامل الاختلال
+
+282
+00:32:51,370 --> 00:32:58,110
+اللي احنا شفناه من المظاهر اللي شفتوها أو المفروض
+
+283
+00:32:58,110 --> 00:33:04,350
+يعني هي تعتبر جزء من الـ Anatomy اللي هي قضية الـ
+
+284
+00:33:04,350 --> 00:33:08,790
+Embryology الـ Embryology كيف الإنسان بتخلق وكيف
+
+285
+00:33:08,790 --> 00:33:12,990
+الخلايا بتهاجر وكيف بتنمو بهذا الشكل
+
+286
+00:33:16,740 --> 00:33:24,000
+الـ… الـ… الـEmbryogenesis بالأخير، هجرت الخلايا
+
+287
+00:33:24,000 --> 00:33:28,940
+زي حتى خلايا المناعة أو خلايا الدم تبدأ في كيس
+
+288
+00:33:28,940 --> 00:33:34,980
+المحة اللي هي في الـEgg Yolk تنتقل للـLiver
+
+289
+00:33:34,980 --> 00:33:39,340
+والـSpleen للكبد والتحال، وبعدين تنتقل في الـBone
+
+290
+00:33:39,340 --> 00:33:43,930
+Marrow بس يولد الإنسان بتبين بالـBone Marrowبالـ
+
+291
+00:33:43,930 --> 00:33:48,110
+Bomber وبشكل أساسي هذه الهجرة أو هذا التنقل أو هذا
+
+292
+00:33:48,110 --> 00:33:58,730
+التطور عبارة عن ظواهر محكومة بدوافع، بمؤشرات أو
+
+293
+00:33:58,730 --> 00:34:02,390
+بـ، يعني فيه إشي بيقول الخلية أترك هنا و أروح
+
+294
+00:34:02,390 --> 00:34:10,550
+هناك، فيه إشي بيقول الخلية أعمل هيك وسوي هيكففي
+
+295
+00:34:10,550 --> 00:34:16,190
+حالة يمكن حتى إذا دخل باللي قبل شوية تسمينها الـ
+
+296
+00:34:16,190 --> 00:34:23,130
+Robin Sequence من المشاكل أحيانًا بعض الناس الأصل
+
+297
+00:34:23,130 --> 00:34:27,970
+في الإنسان الـNormal يعني تخيلنا هذه الصورة إنه
+
+298
+00:34:27,970 --> 00:34:35,070
+تكون الذقن السفلي أو الفك السفلي هجم معين بيكون
+
+299
+00:34:35,070 --> 00:34:37,410
+يعني
+
+300
+00:34:38,140 --> 00:34:45,640
+متتكوّن بشكل طبيعي بحيث أنه يعطي مجال للسام ينمو
+
+301
+00:34:45,640 --> 00:34:52,660
+بشكل طبيعي أحياناً حتى بعض الناس بيكون الذقن تبعه
+
+302
+00:34:52,660 --> 00:34:58,460
+يمكن يتجانب منه عائلي يعني وراثة بتشوف شكل الوجه
+
+303
+00:34:58,460 --> 00:35:03,320
+كيف في تقارب بين الأباء و الأمات وبتلاقي بعض الناس
+
+304
+00:35:03,320 --> 00:35:10,620
+الذقن جاي لورا وبنسميهالـ Receding أو Hypoplasia
+
+305
+00:35:10,620 --> 00:35:15,240
+of the mandible وPosterior displacement of the
+
+306
+00:35:15,240 --> 00:35:19,720
+tongue يعني اللي هي زي ما هم شايفين هنا يعني هي
+
+307
+00:35:19,720 --> 00:35:28,200
+أحيانًا حتى إنسان يولد بشكل طبيعي يعني قضيني إذا
+
+308
+00:35:28,200 --> 00:35:32,760
+حد بتشوف يعني البارح بتطلع انتخابات الأمريكية
+
+309
+00:35:32,760 --> 00:35:40,160
+الرئيس الـمدرسة الشيوخ «السناترز» الأمريكي «جون
+
+310
+00:35:40,160 --> 00:35:45,920
+ماتشيل» يظن اسمه واحد بيشوف الفك السفلي راجع لورا
+
+311
+00:35:45,920 --> 00:35:55,100
+كتير والـ «طاند» بيكون ألسان مش ماخد مكانه السليم
+
+312
+00:35:55,100 --> 00:36:01,020
+وبالتالي هذا ممكن يسبب شخير ممكن يسببتضيق في
+
+313
+00:36:01,020 --> 00:36:08,980
+المجال التنفسي وإشكالات ممكن يعمل مشاكل فجزء من
+
+314
+00:36:08,980 --> 00:36:12,840
+المشاكل طبعاً فيه اللي بيسموها الـ «لثة» والـ
+
+315
+00:36:12,840 --> 00:36:18,820
+«شفة» ويعني عبارة عن تطور الـ «Embryogenesis» في
+
+316
+00:36:18,820 --> 00:36:24,200
+هذه المنطقة في الفم والأعلى الشفة العليا بيصير
+
+317
+00:36:24,200 --> 00:36:26,200
+«Clift Lip» و«Clift Palate»
+
+318
+00:36:31,470 --> 00:36:37,930
+العربية ويكون هنا فيه مشكلة فالـ Cliff-tip وبلد
+
+319
+00:36:37,930 --> 00:36:44,270
+الإنسان الطبيعي بيكون هكذا أنا شكله طبعاً تحت
+
+320
+00:36:44,270 --> 00:36:52,110
+بينهم هدولة في الددار الخلفي للحلق بتلاقي tonsils
+
+321
+00:36:52,110 --> 00:36:58,550
+وبتلاقي لسان الأصل يكون بشكل معين عندهم هذه
+
+322
+00:36:58,550 --> 00:37:05,320
+المشكلة أحياناًبنلاقي مش هيك شكل مدبّب لفتحة الحلق
+
+323
+00:37:05,320 --> 00:37:17,700
+بتلاقيها مش V على شكل U فتحة الحلق وبالتالي، هذه
+
+324
+00:37:17,700 --> 00:37:25,920
+ممكن تكون من المشاكل التطورات هذه الخلقية تبدأ
+
+325
+00:37:26,650 --> 00:37:31,570
+يعني ممكن واحد يلاحظها من الأسبوع الـ11، السابع
+
+326
+00:37:31,570 --> 00:37:36,370
+عشر من الحمل للأسبوع العشرين للأسبوع التسعة وعشرين
+
+327
+00:37:36,370 --> 00:37:43,710
+كيف الإنسان بيتطور والخلايا بتهاجر وبتكبر وبتصير
+
+328
+00:37:43,710 --> 00:37:48,830
+الـDevelopment تبعته يعني لو أحد شاف عيلة عندها
+
+329
+00:37:48,830 --> 00:37:53,760
+هذه الظاهرةأو بعض الذات أحلى شيء وأحسن شيء يكون
+
+330
+00:37:53,760 --> 00:37:57,760
+مجموعة مصابين عندهم المرض ومجموعة مش مصابين في نفس
+
+331
+00:37:57,760 --> 00:38:03,200
+العائلة في هذه الحالة ممكن تروح الواحد يدور على
+
+332
+00:38:03,200 --> 00:38:10,340
+المشاكل أو وين المشكلة فيها في
+
+333
+00:38:10,340 --> 00:38:20,010
+موضوع مهم كثيريعني إيه دخل بالدين وبالعقيدة
+
+334
+00:38:20,010 --> 00:38:30,750
+وبالكيف بيميز الواحد حاله عن الآخرين؟ قضية يعني
+
+335
+00:38:30,750 --> 00:38:35,670
+إحنا مقتنعين إن الله سبحانه وتعالى خلق آدم وحواء
+
+336
+00:38:35,670 --> 00:38:41,890
+من خلق مباشر وبغير يعني
+
+337
+00:38:44,160 --> 00:38:51,780
+بشكل مباشر، يعني ما أطورنا من بين قوسين قرد أو أصل
+
+338
+00:38:51,780 --> 00:38:59,720
+أشي مشابه للقرد ونشقّنا عنهم وكدا، الآن الإيمان
+
+339
+00:38:59,720 --> 00:39:07,780
+بهذا الجانب، صحيح، والإيمان دائماً بقول بالـ
+
+340
+00:39:07,780 --> 00:39:11,760
+Carbon-Cosموعة بقول الإيمان بالغيب، يعني الإيمان
+
+341
+00:39:11,760 --> 00:39:17,770
+إنك أنتهذا جانب ربنا حكى عنه «ما أشهدتهم خلق
+
+342
+00:39:17,770 --> 00:39:21,770
+السماوات والأرض، ولا خلق أنفسهم، وما كنتم اتخذ
+
+343
+00:39:21,770 --> 00:39:26,830
+المظلين عضوًا» يعني ربنا قرر، والقرآن ما أظن أن
+
+344
+00:39:26,830 --> 00:39:33,610
+حدا أثبت أنه فيه جانب مخطئ أو خاطئ فربنا حكى «أنا
+
+345
+00:39:33,610 --> 00:39:38,330
+ما فرجيتكم كيف خلقتكم، كيف بدأتكم، كيف كذا» وهذا
+
+346
+00:39:38,330 --> 00:39:42,150
+يعني جانب
+
+347
+00:39:43,270 --> 00:39:54,390
+أنا مؤمن به ولكن هذا الإيمان لا يتنافى مع طلب الله
+
+348
+00:39:54,390 --> 00:40:04,010
+أيضًا إن النظر وتفكير العقل وتفكير
+
+349
+00:40:04,010 --> 00:40:10,870
+أطلاق نشاط الدماغ ربنا كرّم آدم وخلّى الملائكة
+
+350
+00:40:10,870 --> 00:40:20,740
+تسجد لهرفض بعضها أو رفضهم واستغرابهم لقضية إنه
+
+351
+00:40:20,740 --> 00:40:27,660
+عندنا عقل شغلناه يعني لما
+
+352
+00:40:27,660 --> 00:40:32,860
+ربنا طلب من الملائك تسمية أسماء شيء معين يعني زي
+
+353
+00:40:32,860 --> 00:40:39,140
+أعطاهم مسألة أو أعمال
+
+354
+00:40:39,140 --> 00:40:41,300
+العقل والذهن والتفكير
+
+355
+00:40:43,830 --> 00:40:51,930
+فهذا هو ما يميز الإنسان هو مناطق تكليف الإنسان فإن
+
+356
+00:40:51,930 --> 00:40:59,270
+الواحد ينظر كيف ربنا بيخلق الأشياء أحيانًا
+
+357
+00:40:59,270 --> 00:41:05,070
+اللادينيين رفضوا بين قوسين خصوصًا في المجتمع
+
+358
+00:41:05,070 --> 00:41:10,490
+الغربي الكنيسة لأن الكنيسة أجرمت
+
+359
+00:41:12,660 --> 00:41:19,420
+كانت تحاول تحدد من قدرة العالم على الدراسة وعلى
+
+360
+00:41:19,420 --> 00:41:26,080
+التفكير وعلى الاستنتاج أنا أقول التشابهات اللي
+
+361
+00:41:26,080 --> 00:41:33,120
+دفعت بعض العلماء إلى القلب
+
+362
+00:41:33,120 --> 00:41:37,940
+أو المنادة بالتطور والـEvolution
+
+363
+00:41:39,830 --> 00:41:46,930
+إن الكائنات الحية من بعض، هذا كلام صحيح وفي
+
+364
+00:41:46,930 --> 00:41:50,050
+تشابهات
+
+365
+00:41:50,050 --> 00:41:57,670
+معينة بين الكائنات في طريقة بنائها، طريقة عملها
+
+366
+00:41:57,670 --> 00:42:04,370
+أنا أقول، يعني، بدي أفهمها لوحدة على إنها مؤشرة
+
+367
+00:42:04,370 --> 00:42:12,270
+على إن الخالق واحد، المنشئ واحدوهذه أكفأ وأحسن
+
+368
+00:42:12,270 --> 00:42:15,470
+ويعني
+
+369
+00:42:15,470 --> 00:42:19,650
+لما ربنا قد كتبنا في الزبور من بعد الذكر أن الأرض
+
+370
+00:42:19,650 --> 00:42:25,230
+يرثها عبادي الصالحون الصالحون يعني هنا يمكن يكون
+
+371
+00:42:25,230 --> 00:42:29,470
+على مستوى إذا أردنا البشر من الصالحين من البشر
+
+372
+00:42:29,470 --> 00:42:38,540
+ولكن على مدى كما نرى في الأحافير وفي الـالسجل
+
+373
+00:42:38,540 --> 00:42:46,920
+القديم من تكون الخلق على الأرض بنلاقي إنه يعني
+
+374
+00:42:46,920 --> 00:42:54,100
+هناك تطور بشكل معين يعني فمن الأشياء اللي أجدها
+
+375
+00:42:54,100 --> 00:42:58,900
+مثيرة وبحاول أقرا عنها وأدرسها راح نيجي على جانب
+
+376
+00:42:58,900 --> 00:43:06,630
+آخر فيها تشابه فيتطور الإنسان بالذات في مرحلة
+
+377
+00:43:06,630 --> 00:43:11,330
+الجنين
+
+378
+00:43:11,330 --> 00:43:16,270
+وبعد ذلك الولادة وبعد ذلك النمو والبلوغ ثم بعد ذلك
+
+379
+00:43:16,270 --> 00:43:26,890
+الهرم والوفاة فالإنسان هنا بيحاول أن يظهروا
+
+380
+00:43:26,890 --> 00:43:34,870
+مدى تشابه أو اختلافالتركيب العظمي، يعني هذا جانب
+
+381
+00:43:34,870 --> 00:43:43,810
+مهم في علم الأحافير وعلم تحديد الأجناس وتحديد ما
+
+382
+00:43:43,810 --> 00:43:48,790
+هو الكائن اللي هذه العظمة منه، يعني دراسة الإضاءة،
+
+383
+00:43:48,790 --> 00:43:56,160
+فمن دراسات الإضاءة المهمةإنه أرقى كائن حي ولقد
+
+384
+00:43:56,160 --> 00:44:00,800
+خلقنا الإنسان في أحسن تقويم اللي هو الإنسان يعني
+
+385
+00:44:00,800 --> 00:44:08,280
+حقيقة إن الإنسان يقف منتصب على رجلين ويدايه هرتان
+
+386
+00:44:08,280 --> 00:44:14,500
+يحركما كما يشاء في إن الواحد بكتب، برسم، بشتغل
+
+387
+00:44:14,500 --> 00:44:20,720
+بيده، بآلة، كذا كذاهذه قضية يعني سبحان الله معجزة
+
+388
+00:44:20,720 --> 00:44:28,520
+ورائعة ودرجة الخلق
+
+389
+00:44:28,520 --> 00:44:34,260
+المتقن المحكم كبيرة جداً فحتى يقف الإنسان بهذا
+
+390
+00:44:34,260 --> 00:44:43,120
+الشكل يجب أن تكون عظامه بشكل محدد فإن عظمة العاضض
+
+391
+00:44:43,120 --> 00:44:49,690
+أو الـ Humerusوبعدين الـ Forearm اللي هين أو يعني
+
+392
+00:44:49,690 --> 00:44:56,590
+هيسموها Upper Arm من منطقة العضد هذه المنطقة
+
+393
+00:44:56,590 --> 00:45:04,710
+وبعدين منطقة اليد أو الـ Forearm اللي هي
+
+394
+00:45:04,710 --> 00:45:11,130
+الـHumerus وبعد الـHumerus أزف الألنى والراديوس
+
+395
+00:45:11,130 --> 00:45:18,190
+وبعدين منطقة الرسماللي هي منطقة الـ Carpels وبعدين
+
+396
+00:45:18,190 --> 00:45:23,330
+الـ Metacarpels والـ Phalanges السلامة باللغة
+
+397
+00:45:23,330 --> 00:45:28,790
+العربية حقيقةً يعني تطور إضام الإنسان بهذا الشكل
+
+398
+00:45:28,790 --> 00:45:37,690
+ماشي يعني تطور الإنسان بهذا الشكل يعني صراحة معجز
+
+399
+00:45:37,690 --> 00:45:41,030
+ومميز
+
+400
+00:45:42,170 --> 00:45:49,910
+مؤدى للهدف إنه الإنسان بأصابعه وبيديه يستطيع أن
+
+401
+00:45:49,910 --> 00:45:55,370
+يعمل أشياء كثيرة جداً جداً الألات والاستخدامات
+
+402
+00:45:55,370 --> 00:46:01,870
+وحتى قضية الإحساس يعني سبحان الله القرآن الكريم
+
+403
+00:46:01,870 --> 00:46:09,340
+معجز يا شباب ويعني لما ربنا يقولّكهيحسب الإنسان
+
+404
+00:46:09,340 --> 00:46:13,820
+ولا نجمع عظامة بلا قادرين على أن نصوية بنانا
+
+405
+00:46:13,820 --> 00:46:22,040
+البصمة هذه البصمة الحقيقية للأنامل الإنسان مميزة
+
+406
+00:46:22,040 --> 00:46:30,520
+لكل واحد لا يوجد أثنين عندهم نفس البصمة وعشان هيك
+
+407
+00:46:30,520 --> 00:46:37,210
+في الطب الشرعيالتحقيقات الجناية وغيرها بيعتمدوا
+
+408
+00:46:37,210 --> 00:46:41,830
+على البصمة اللي تتركها نامل الإنسان فهذه كلها
+
+409
+00:46:41,830 --> 00:46:49,190
+معجزات اللي واحد بيشوفها فلو جينا أخدنا طائرين أو
+
+410
+00:46:49,190 --> 00:46:57,590
+حيوانات تطير مثلًا مثلًا هنا حمامة بتطير أو Bird
+
+411
+00:46:57,590 --> 00:47:06,110
+وبين خفاش الخفاش طبعًا حيوان ثديوهو تطورياً يعني
+
+412
+00:47:06,110 --> 00:47:12,690
+من التدييات التدييات الـ … يعني مش التدييات العليا
+
+413
+00:47:12,690 --> 00:47:19,970
+زي القردة إنما من التدييات السفلة وبكون بسبيلاً
+
+414
+00:47:19,970 --> 00:47:29,670
+يعني بس هو تدي يعني يحمل ويولد ويغطيه شعر الطير
+
+415
+00:47:29,670 --> 00:47:37,760
+تضع البيض ويغطيها ريشيعني بيكون بهذا الشكل ولكن
+
+416
+00:47:37,760 --> 00:47:44,380
+سبحان الله لو جينا نرى التطور العظمي في الأطراف
+
+417
+00:47:44,380 --> 00:47:52,800
+العلوية بنلاقي أن الطير، مجموعة الإضامة إذا الواحد
+
+418
+00:47:52,800 --> 00:48:00,280
+مسك جراح دجاجي وبقزص بالعظم تبعها، بشوف كيف الـ
+
+419
+00:48:02,280 --> 00:48:09,400
+الترتيب العظام الموجود فيها فنرى أن الأزرق يشبه
+
+420
+00:48:09,400 --> 00:48:14,200
+الـ Humerus التنتين اللي هي زي القلنة والـ Tibia
+
+421
+00:48:14,200 --> 00:48:21,180
+تبعاتنا القلنة والـ Radius تبعاتنا بعدين هناك
+
+422
+00:48:21,180 --> 00:48:25,880
+مجموعة من العظام تشبه عظام الرصب وبعدين مجموعة
+
+423
+00:48:25,880 --> 00:48:34,180
+تشبه الأصابع فهي يعني حتى في الطيرتجد أنها ترتيب
+
+424
+00:48:34,180 --> 00:48:40,060
+مشابه أو قريب بس مختلف تمامًا ومربوط معه أشياء
+
+425
+00:48:40,060 --> 00:48:44,520
+بتؤدي وظيفة مختلفة تمامًا على عكس مثلًا الخفاش
+
+426
+00:48:44,520 --> 00:48:49,700
+الخفاش هنا كترتيب
+
+427
+00:48:49,700 --> 00:49:00,180
+عظمي هميته لقضية الطيران أيضًا مثل الطير ولكنبتكون
+
+428
+00:49:00,180 --> 00:49:07,300
+يعني أقرب جداً للعظام ترتيب العظام عند الإنسان
+
+429
+00:49:07,300 --> 00:49:13,440
+فبرضه الـ Humerus قالنا هو الـ Radius وبعدين الرسب
+
+430
+00:49:13,440 --> 00:49:20,280
+تبعه وبعدين الأصابع وعنده هذه الخمس أصابع وحتى عدد
+
+431
+00:49:20,280 --> 00:49:25,860
+السلامة الـ Phalanges قريبة من عدد الـ Phalanges
+
+432
+00:49:25,860 --> 00:49:36,040
+عند الإنسانيعني هذه بالنسبة بالذات للمادة الورافية
+
+433
+00:49:36,040 --> 00:49:44,560
+وتحكم بتطور هذا الموضوع وواحد التفكير ليش ربنا
+
+434
+00:49:44,560 --> 00:49:49,920
+خلقها بهذه الطريقة طبعاً الأجانب أو كثير من الناس
+
+435
+00:49:49,920 --> 00:49:56,260
+كرهة للكنيسة أو تدخلها في العلم بشكل غير سليميعني
+
+436
+00:49:56,260 --> 00:50:04,400
+إحنا الواحد كمسلم ومؤمن يرى التطور بهذا الشكل يجب
+
+437
+00:50:04,400 --> 00:50:09,340
+أن يستفيد منه، يجب أن ينتبه إليه قُل سيروا في
+
+438
+00:50:09,340 --> 00:50:12,760
+الأرض فانظروا كيف خلق الله السماوات والأرض يعني
+
+439
+00:50:12,760 --> 00:50:18,760
+هيك، طلع، ربنا بيقولك شغّل مخك فوجود هذه ظاهرة
+
+440
+00:50:18,760 --> 00:50:26,700
+جميع، يعني التنبه لها المفروضتدفع بالإنسان أن يصبح
+
+441
+00:50:26,700 --> 00:50:33,360
+مؤمن، أنا من رأيه بهذا الشكل بس هم الـ… يعني الـ…
+
+442
+00:50:33,360 --> 00:50:36,820
+أحيانًا كثير من الغربيين أو غير الغربليين يعني
+
+443
+00:50:36,820 --> 00:50:47,780
+يحاولوا من خلال هذه الظواهر ربطها بشكل يعني إن هذا
+
+444
+00:50:47,780 --> 00:50:55,300
+الكائن من ذاك الكائن الآخر وهي يعني أنا بعتبرهم
+
+445
+00:50:55,300 --> 00:51:02,680
+يتوقفوا عن محاولة شرح من الذي قام بذلك، كيف قام
+
+446
+00:51:02,680 --> 00:51:08,240
+بذلك لأن هذه أمور مجهولة بالنسبة للمغيب، وابد أن
+
+447
+00:51:08,240 --> 00:51:17,560
+نؤمن بها بالغيب ففي كثير من ما نراه من
+
+448
+00:51:17,560 --> 00:51:24,270
+خلق الإنسان بشكل معين نجده في الطبيعة وأحيانًايعني
+
+449
+00:51:24,270 --> 00:51:31,710
+هذه استجابة لضغوطات معينة أو ليه؟ يعني لأنها بتعطي
+
+450
+00:51:31,710 --> 00:51:36,510
+فائدة للكائن اللي هيجدد من ناحية يعني ليش الزرافة
+
+451
+00:51:36,510 --> 00:51:41,270
+رقبتها طويلة؟ أنا بقولك لأنه كائنات على مدى يعني
+
+452
+00:51:41,270 --> 00:51:45,690
+بالحفير اللي بنراها لما تكون الرقبة طويلة كثير
+
+453
+00:51:45,690 --> 00:51:50,010
+بتقدر توكل أكل ماحدش يصلوا ليه من الكائنات اللي
+
+454
+00:51:50,010 --> 00:51:57,410
+بترعى بتكون على مستوى أصغر أو أقل وكدهفتجد إنه فيه
+
+455
+00:51:57,410 --> 00:52:03,450
+دافع معين للتطور بشكل معين يعني أنا أظن إن التطور
+
+456
+00:52:03,450 --> 00:52:10,870
+والانتخاب الطبيعي وغيرها من الظواهر هي أدوات يقوم
+
+457
+00:52:10,870 --> 00:52:19,410
+الله سبحانه وتعالى باستخدامها للتغيير وإن كان كل
+
+458
+00:52:19,410 --> 00:52:27,610
+شيء بقدر من الله سبحانه وتعالىهناك حالة اللي هو
+
+459
+00:52:27,610 --> 00:52:34,390
+سموها الـ Proteus Syndrome يعني الغريب، يعني هذه
+
+460
+00:52:34,390 --> 00:52:41,010
+حالة وقرافية دلوقت بقرا عن تفاصيلها هي
+
+461
+00:52:41,010 --> 00:52:49,250
+Developmental، يعني قضية التطور هناك اختلالات في
+
+462
+00:52:49,250 --> 00:52:58,140
+معدلات التطورالعضاء في جسم الإنسان يعني زي ما هنا
+
+463
+00:52:58,140 --> 00:53:05,020
+تعطونا مثال عليه طفل عندما يولد وولد بشكل طبيعي
+
+464
+00:53:05,020 --> 00:53:11,640
+وأحجام عضاءه متناسقة ولكن بعد السنة الأولى بدر ما
+
+465
+00:53:11,640 --> 00:53:19,060
+يعني يولد بشكل متناسق متساوي في كل الأعضاء عبارة
+
+466
+00:53:19,060 --> 00:53:28,560
+عن أنهمجموعة مثلًا الرجلين صارت أصابع رجليه بتكبر
+
+467
+00:53:28,560 --> 00:53:37,020
+بشكل غير متناسب جزء من وجهه نمى وجزء لم ينمو جزء
+
+468
+00:53:37,020 --> 00:53:42,800
+من جسمه نمى وجزء آخر لم ينمو هذا يسمى الـ Proteus
+
+469
+00:53:42,800 --> 00:53:54,060
+Syndrome والآن يعني لقوابرضه Activator معين
+
+470
+00:53:54,060 --> 00:54:02,040
+Transcriptional Activator في موقع آخر فالفكرة يعني
+
+471
+00:54:02,040 --> 00:54:09,320
+هنا اللي بديوا ياخدوها إنه ليش تحدث إنه في مجموعة
+
+472
+00:54:09,320 --> 00:54:16,340
+خلايا نمت بشكل بالـ Brotius Syndrome هذا يعني
+
+473
+00:54:16,340 --> 00:54:25,820
+نمت بشكل أكبر من غيرهابدأت تتذكر إن الإنسان يبدأ
+
+474
+00:54:25,820 --> 00:54:31,300
+من fertilized egg من خلية بويضة ملقحة طبعاً
+
+475
+00:54:31,300 --> 00:54:35,140
+البويضة قبل التلقيح بتكون قريبة من هذا الشكل بتكون
+
+476
+00:54:35,140 --> 00:54:38,940
+فيه two polar bodies طبعاً هذه صور في الغالب
+
+477
+00:54:38,940 --> 00:54:44,560
+أخدوها من الـ In-vitro fertilization هذه القضية من
+
+478
+00:54:44,560 --> 00:54:49,830
+السبعينات والثمانينات بدأتالتلقيح الصناعي والتلقيح
+
+479
+00:54:49,830 --> 00:54:55,650
+خالج الجسم للإناث أو النساء اللي عندهم مشاكل في
+
+480
+00:54:55,650 --> 00:55:00,370
+الـ Fallopian Tubes يعني هما عندهم كل شيء آخر
+
+481
+00:55:00,370 --> 00:55:07,370
+طبيعي المبيض طبيعي، الرحم طبيعي ولكن طرف الرحم عند
+
+482
+00:55:07,370 --> 00:55:16,350
+المبيض فيه تسكير بالطريق وإغلاق فكانت الحل أنهلما
+
+483
+00:55:16,350 --> 00:55:23,210
+تصير عملية التبويض عند الأنثى هذه تأخذ البوايضة
+
+484
+00:55:23,210 --> 00:55:28,010
+لأن الـ IVF بيحفظوا إنتاج البوايضات حتى يكون عندنا
+
+485
+00:55:28,010 --> 00:55:33,310
+عدد كبير من البوايضات حتى يكون فيه احتمالية حمل
+
+486
+00:55:33,310 --> 00:55:40,370
+كبيرة يعني الأصل بعد ما يعملوا عملية التلقيح
+
+487
+00:55:40,370 --> 00:55:44,990
+ويتكون الأمور سليمة
+
+488
+00:55:45,370 --> 00:55:49,470
+في عملية الارجاع للرحم لازم يعني ثلاث eggs
+
+489
+00:55:49,470 --> 00:55:54,290
+fertilized ليرجعوا علشان يكون فيه احتمالية أن يكون
+
+490
+00:55:54,290 --> 00:55:59,010
+فيه حمل مظبوط فاللي بدأوا يتذكروا أنه من الأشياء
+
+491
+00:55:59,010 --> 00:56:05,650
+اللي تم دراستها قضية أنه الخلية هذه تنقسم إلى
+
+492
+00:56:05,650 --> 00:56:10,370
+خليتين بعد التلقية والخليتين يصيروا أربعة بالـC
+
+493
+00:56:10,370 --> 00:56:14,090
+وبعدين هدول الأربعة بتتحول لثمانية وبعدين ستاشر
+
+494
+00:56:15,270 --> 00:56:22,350
+يومين أو كل يوم يعني الـ Day Zero هنا اللي هي
+
+495
+00:56:22,350 --> 00:56:29,570
+fertilized egg واحدة بس بعد يوم تصبح خليتين بعد
+
+496
+00:56:29,570 --> 00:56:36,030
+يوم ثالث اليوم الثاني بيصيروا أربعة يعني هذه
+
+497
+00:56:36,030 --> 00:56:45,610
+متوالية هندسية أثنين لأُس عدد الأيام ماشيبكون نسبة
+
+498
+00:56:45,610 --> 00:56:55,670
+سرعة في النمو عالية جدًا فيه
+
+499
+00:56:55,670 --> 00:57:04,090
+دائمًا مثل أو كلمة قال أسرع سرطان في نمو نموًا في
+
+500
+00:57:04,090 --> 00:57:12,100
+الجسم هو الجنين الطبيعي تبدأ من خلية واحدةبتتحول
+
+501
+00:57:12,100 --> 00:57:17,340
+لما يولد الإنسان عادةً يعني تلات أو أربعة كيلوز
+
+502
+00:57:17,340 --> 00:57:23,780
+ماشي زائد المشيمة زائد السائل المنيوسي وكذا ويكون
+
+503
+00:57:23,780 --> 00:57:28,140
+له مجموعة كبيرة فبالنسبة
+
+504
+00:57:28,140 --> 00:57:33,660
+في عملية الـ In vitro fertilization بيستطيعوا
+
+505
+00:57:33,660 --> 00:57:39,440
+يراقبوا تطور هذه الخلايا بشكل يومي بشكل دقيق كذا
+
+506
+00:57:39,900 --> 00:57:48,200
+فطبعًا بتكون صورها بهذا الشكل ونتكلم يعني على إنه
+
+507
+00:57:48,200 --> 00:57:54,280
+بعد ذلك تصبح يعني اللي هي مراحل النطفة، العلقة،
+
+508
+00:57:54,280 --> 00:57:58,380
+المضغة، الـ «كذا» يعني اللي ربنا حكي عنها حقيقةً
+
+509
+00:57:58,380 --> 00:58:04,880
+أجمل وصف للتطور اللي أحنا بنشوفه الـPlastocyst هذه
+
+510
+00:58:04,880 --> 00:58:11,180
+هي تصل مرحلة العلقةاللي هي المفروض إنها تعلق في
+
+511
+00:58:11,180 --> 00:58:18,980
+جدار الرحم وبالتالي يعني بعدين تنمو
+
+512
+00:58:18,980 --> 00:58:25,580
+داخله بحيث إنه تكون Machine أو تكون الطبقات اللي
+
+513
+00:58:25,580 --> 00:58:35,810
+هو الكيس الحمل بهذا الشكل، الإنسان سيتكونمن مجموعة
+
+514
+00:58:35,810 --> 00:58:39,550
+الخلايا اللي هنا اللي هي في الطبقة هذه هذه كله
+
+515
+00:58:39,550 --> 00:58:45,230
+بالـ Imperiology المفروض تكونوا ماخدينها وهنا الـ
+
+516
+00:58:45,230 --> 00:58:48,650
+Ammoniac Fluid الـ Ammoniac Cavity بيبدأ يتكون
+
+517
+00:58:48,650 --> 00:58:53,810
+ويتشكل لما هنا تعلق في الرحم إحنا عندنا هنا مرحلة
+
+518
+00:58:53,810 --> 00:59:02,710
+العلقة فالفكرة أنه أحيانًا يعني كل يعني هناك فكرة
+
+519
+00:59:02,710 --> 00:59:11,380
+تامالفكرة الأولى إنه أي خلية حتى تمشي وتسير وتنتقل
+
+520
+00:59:11,380 --> 00:59:19,020
+بهذا الإتجار يجب أن يكون ناتج عن عوامل تخبرها
+
+521
+00:59:19,020 --> 00:59:24,600
+بأنها تتحرك بهذا الإتجار فنجد أن مجموعة Activator
+
+522
+00:59:24,600 --> 00:59:30,480
+Genes، Activator Proteins هما السبب في أن تتحرك
+
+523
+00:59:30,480 --> 00:59:35,890
+الخلية بهذا الإتجارودراسة هذا الموضوع أحيانًا من
+
+524
+00:59:35,890 --> 00:59:42,370
+الدوراسات المهمة اللي بتوضح لنا كيف ربنا خلقنا
+
+525
+00:59:42,370 --> 00:59:47,450
+وكيف الخلايا بتمشي بهذا الشكل فهنا صورة لمراحل
+
+526
+00:59:47,450 --> 00:59:56,030
+بداية التعلق للـBastocyst اللي هي العلقة الفكرة
+
+527
+00:59:56,030 --> 01:00:00,810
+أيضًا إن هناك راح يصبح تخصص لكل خلية
+
+528
+01:00:04,260 --> 01:00:09,000
+فمثلًا، الخلايا الدم فيما فيها خلايا المناعة من
+
+529
+01:00:09,000 --> 01:00:12,340
+أنواع مختلفة الـ Liver and Joints يعني
+
+530
+01:00:12,340 --> 01:00:17,820
+الـLymphocytes اللي هي الخلايا الليمفاوية مش أقل
+
+531
+01:00:17,820 --> 01:00:23,560
+بشكل محدد من ما يقارب الآن 30 نوع خلية كل واحدة
+
+532
+01:00:23,560 --> 01:00:31,200
+لها محددات حتى تسير بهذا الاتجاه فالخلايا الدم
+
+533
+01:00:32,620 --> 01:00:39,200
+الخلية الجذعية للمكوّنة لخلايا الدم تنقسم بشكل
+
+534
+01:00:39,200 --> 01:00:44,700
+ملحوظ لنوعين فيه ما يسمى الـ Myeloid Series والـ
+
+535
+01:00:44,700 --> 01:00:49,920
+Lymphoid Series الـ Myeloid Series مثلًا جزء منها
+
+536
+01:00:49,920 --> 01:00:53,700
+ما سيعطينا خلية الدم الحمراء التي تحمل الـ
+
+537
+01:00:53,700 --> 01:00:56,340
+Hemoglobin اللي بدا أضيفها تعطينا الـ Oxygen
+
+538
+01:00:56,340 --> 01:01:02,170
+وتنقله في الجسم في الجهاز الدوري الـالخلية التي
+
+539
+01:01:02,170 --> 01:01:10,250
+ستصبح خلية دم حمراء يجب أن تتطور بشكل
+
+540
+01:01:10,250 --> 01:01:14,690
+محدد وتبني الـHemoglobin وبعدين تفقد الـNucleus
+
+541
+01:01:14,690 --> 01:01:17,690
+وبعدين كذا الـMegacaryocytes تتحول إلى
+
+542
+01:01:17,690 --> 01:01:25,330
+الـPlatelets الـOthers سواء خلايا الحبابية
+
+543
+01:01:25,330 --> 01:01:27,850
+اللي هي الـNeutrophils والـXenophils والـBasophils
+
+544
+01:01:27,850 --> 01:01:31,910
+والمعصّلاتبتكون باتجاه معين والـ «مانوسايتز»
+
+545
+01:01:31,910 --> 01:01:32,770
+«مانوسايتز» «مانوسايتز» «مانوسايتز» «مانوسايتز»
+
+546
+01:01:32,770 --> 01:01:33,850
+«مانوسايتز» «مانوسايتز» «مانوسايتز» «مانوسايتز»
+
+547
+01:01:33,850 --> 01:01:34,950
+«مانوسايتز» «مانوسايتز» «مانوسايتز» «مانوسايتز»
+
+548
+01:01:34,950 --> 01:01:38,510
+«مانوسايتز» «مانوسايتز» «مانوسايتز» «مانوسايتز»
+
+549
+01:01:38,510 --> 01:01:39,650
+«مانوسايتز» «مانوسايتز» «مانوسايتز» «مانوسايتز»
+
+550
+01:01:39,650 --> 01:01:50,110
+«مانوسايتز» «مانوسايتز» «مانوسايتز» «مانوسايتز»
+
+551
+01:01:50,110 --> 01:01:55,090
+«مانوسايتز»
+
+552
+01:01:55,090 --> 01:01:59,170
+«مانوساوبمعرفة أيش المحددات اللي تمشي بهذا الاتجاه
+
+553
+01:01:59,170 --> 01:02:03,910
+يعني نتذكر إن الـ Red Blood Cells حتى تمشي الخلايا
+
+554
+01:02:03,910 --> 01:02:06,950
+وينكون Red Blood Cells بدنا هرمون الـ
+
+555
+01:02:06,950 --> 01:02:11,790
+Erythropoietin يعني أنا بحكي للواحد، بتذكر إن الـ
+
+556
+01:02:11,790 --> 01:02:17,210
+Erythropoietin عبارة عن هرمون بيشتغل على الخلايا
+
+557
+01:02:17,210 --> 01:02:21,930
+اللي هتصير Red Blood Cells طبعاً هو هرمون عبارة عن
+
+558
+01:02:21,930 --> 01:02:27,060
+بروتين وبدو يشتغل عن طريق Receptorفالـ Expression
+
+559
+01:02:27,060 --> 01:02:32,920
+وظهور الـ Receptor هو أول اختلال أو تغير بشوفه
+
+560
+01:02:32,920 --> 01:02:36,640
+بالـ Myeloid Progenitor عشان نعرف إن هاي راح تصير
+
+561
+01:02:36,640 --> 01:02:40,640
+Red Blood Cells بعدين لأن الخلية لازم تعرض الـ
+
+562
+01:02:40,640 --> 01:02:44,620
+Erythropoietin Receptor وبعدين الـ Erythropoietin
+
+563
+01:02:44,620 --> 01:02:50,540
+بيجي وبيكون إنه بيجبرها على إنه تروح بهذا الاتجاه
+
+564
+01:02:51,390 --> 01:02:57,230
+الـ Platelets، الـ «ترومبو بايتين» قالوا صاروا
+
+565
+01:02:57,230 --> 01:03:03,150
+لقوه كانوا يقولوا قبل الـ «إنترلوكن 11» مثلاً الـ
+
+566
+01:03:03,150 --> 01:03:07,850
+«مونوسايتس» والـ «T سيلز» والـ «B سيلز» كلهم تحت
+
+567
+01:03:07,850 --> 01:03:14,610
+أثير مؤشرات خارجية والمؤشرات الخارجية هذه الـ
+
+568
+01:03:14,610 --> 01:03:20,340
+External بتشتغل على Receptors والـ Receptorsتشتغل
+
+569
+01:03:20,340 --> 01:03:25,840
+جوا الخلية من خلال Activators معينين فكل هذه
+
+570
+01:03:25,840 --> 01:03:31,620
+الأنظمة سبحان الله أحياناً بتكون مسببة للأمراض
+
+571
+01:03:31,620 --> 01:03:36,640
+وضروري أننا نفهمها الآن
+
+572
+01:03:36,640 --> 01:03:45,880
+هناك يعني دفعة قوية لطريقة الاستفادة من قدرة
+
+573
+01:03:45,880 --> 01:03:55,350
+الخلايا على الإعطاءأعضاء وأنسجة بشكل مختلف وهي
+
+574
+01:03:55,350 --> 01:04:04,190
+قضية العلاج بالخلايا الجذعية جزء من قدرة الجسم على
+
+575
+01:04:04,190 --> 01:04:08,970
+تعويض نفسه وعلى بناء نفسه مرة ثانية وأعضاه وأجزته
+
+576
+01:04:08,970 --> 01:04:16,050
+بيكون من خلال الخلايا الجذعية هناك خلايا جذعية
+
+577
+01:04:16,050 --> 01:04:26,300
+يعنيحتى الخلايا الجذعية درجات وأنواع وكذا يعني إذا
+
+578
+01:04:26,300 --> 01:04:31,760
+مثلًا واحد عنده حرق واستطعت أجيب من جلده خلايا
+
+579
+01:04:31,760 --> 01:04:39,340
+جذعية جلدية اللي بدأت تتخصص باتجاه الجلد وأنا أكون
+
+580
+01:04:39,340 --> 01:04:45,660
+عنده قدرة على أني أكتشف أو أكون قد اكتشفتالمركبات
+
+581
+01:04:45,660 --> 01:04:51,060
+الهرمونية أو الدوافع لأن هذا الجلد يتكوّن هذا
+
+582
+01:04:51,060 --> 01:04:59,120
+الجلد يتكافر، هذا الجلد ينتشر فإذا استطعت أني أخذ
+
+583
+01:04:59,120 --> 01:05:06,120
+منه وأنشطه وأستخدمه
+
+584
+01:05:06,120 --> 01:05:10,840
+بعدين في قضية بناء الجسم مرة ثانية، هذا من أروع
+
+585
+01:05:10,840 --> 01:05:18,870
+الأشياءهناك طبعًا يعني جزء من الموضوع أنه لماذا
+
+586
+01:05:18,870 --> 01:05:25,550
+تدرس هذه القضايا أحيانًا أنه زي ما شُفنا بهذا
+
+587
+01:05:25,550 --> 01:05:34,570
+الشكل وشُفنا الصورة من قبل ممكن يعني هنا اللي هي
+
+588
+01:05:34,570 --> 01:05:43,270
+زي ما يُقال آليات التعامل مع الخلايا الجذعيةبكون
+
+589
+01:05:43,270 --> 01:05:53,130
+هنا يعني نوع من الـ suction نوع من الـ يعني عبارة
+
+590
+01:05:53,130 --> 01:05:59,470
+عن تفريغ هواء بحيث أنه تمسك القطع يعني زي الكرة
+
+591
+01:05:59,470 --> 01:06:06,410
+عاملةأو عمقود عنب مثلًا نسميه ممسوك بشكل مثبت وإله
+
+592
+01:06:06,410 --> 01:06:15,190
+بهذه القطعة وندخل إبرة تحت الميكروسكوب كل هذا نأخذ
+
+593
+01:06:15,190 --> 01:06:22,130
+عينة خلية واحدة ناخدها وندرسها فهذه إعلان
+
+594
+01:06:22,130 --> 01:06:26,530
+الإمكانات بالنسبة للخلايا الجدعية متقدمة ويمكن
+
+595
+01:06:26,530 --> 01:06:28,490
+الاستفادة منها
+
+596
+01:06:34,620 --> 01:06:40,440
+الاستفادة من الخلايا الجذعية في الخلايا الجسمانية
+
+597
+01:06:40,440 --> 01:06:49,020
+ماشي، يعني بالذات أنا ذكرت الأهم جانبين الخلايا
+
+598
+01:06:49,020 --> 01:06:53,520
+الجذعية ممكن تستفاد منها ولا يوجد عليها مشاكل أو
+
+599
+01:06:53,520 --> 01:06:59,840
+مشاكل الأمراضقضية نقلة الـ Thalassemia أو الـ
+
+600
+01:06:59,840 --> 01:07:03,800
+Hemoglobinopathies إن الواحد يعوض الجينات تبع الـ
+
+601
+01:07:03,800 --> 01:07:07,860
+Hemoglobin أو مثلًا أمراض نخصة من المناعة الأولية
+
+602
+01:07:07,860 --> 01:07:13,460
+Primary Immune Deficiencies هذه مثبتة وما فيش
+
+603
+01:07:13,460 --> 01:07:23,420
+عليها مشاكل لما الواحد يدخل في خلايامش Somatic،
+
+604
+01:07:23,420 --> 01:07:30,420
+عبارة عن ناقلة للمادة الورافية زي المبايد الخاصة،
+
+605
+01:07:30,420 --> 01:07:42,340
+الـTesticles، الـEmbryos بشكل مختلف بيصير هناك
+
+606
+01:07:42,340 --> 01:07:48,060
+إشكالات أخلاقية يجب أن ينتبه إليها الواحدحكينا
+
+607
+01:07:48,060 --> 01:07:52,500
+مثال من قبل على واحد استخدام الـ CRISPR وهو هذه
+
+608
+01:07:52,500 --> 01:07:59,220
+بتتعدل بطريقة مختلفة محاولة دراسة هذه النواحي مهمة
+
+609
+01:07:59,220 --> 01:08:06,080
+كثير ويلها تدخل في تطور الإنسان العلاقة لما نكون
+
+610
+01:08:06,080 --> 01:08:11,300
+نشوف
+
+611
+01:08:11,300 --> 01:08:23,710
+قضية إنه عبارة عنلمن يكون هناك توأم في الحمل نسبة
+
+612
+01:08:23,710 --> 01:08:32,150
+35% بيكونوا التوأمين
+
+613
+01:08:32,150 --> 01:08:41,870
+كل واحد منهم له كيس ماء ويعني تطور منفصل تماماً
+
+614
+01:08:41,870 --> 01:08:49,070
+هذا تقريباً نسبته 35%ولمّا العلبة تنقسم وتصبح
+
+615
+01:08:49,070 --> 01:08:56,330
+الـInners الماس اللي هو سيعطينا جسم الإنسان بيكون
+
+616
+01:08:56,330 --> 01:09:03,730
+ضمن نفس الكيس الواحد وينفصل إلى اتنين، هذا بيسمونه
+
+617
+01:09:03,730 --> 01:09:07,470
+«مونو كوريونيك» كوريونيك اللي هو الـAmmuniotic أو
+
+618
+01:09:07,470 --> 01:09:13,110
+الكوريون اللي هو طبقة المشيمة «Diamagnotic» بيكون
+
+619
+01:09:13,110 --> 01:09:21,560
+بهذا الشكلهذا بيكون إنه الإنفصال لجنينين شخصين راح
+
+620
+01:09:21,560 --> 01:09:30,480
+يصيروا بعدين في بعد التلقيح بأسبوع تقريبًا إذا كان
+
+621
+01:09:30,480 --> 01:09:37,760
+بعد الأسبوع بمدة أكبر بيكون ترتيب المشيلمة بشكل
+
+622
+01:09:37,760 --> 01:09:44,620
+مختلف وهذا عمليًا نادر جدًايعني اللي هي بالغلاق،
+
+623
+01:09:44,620 --> 01:09:49,120
+مرات، توائم، بيسموها سيامية أو بيكون مشتركة مع بعض
+
+624
+01:09:49,120 --> 01:10:00,740
+بشكل مختلف بس هنا ترتيب اللي هي ترتيب الـ… الـ…
+
+625
+01:10:00,740 --> 01:10:07,580
+الـMachine أو ترتيب قضية التطور للكائن الحي أو
+
+626
+01:10:07,580 --> 01:10:14,040
+الإنسان هناهناك يعني من الضواهر اللي ذكرنا عنها في
+
+627
+01:10:14,040 --> 01:10:22,340
+قضية التطور يعني اختلاف تركيب الجينات وأنا أتوقع
+
+628
+01:10:22,340 --> 01:10:31,620
+يعني لما نحاول الواحد يعني لما ذكرنا تطور الـ
+
+629
+01:10:31,620 --> 01:10:37,260
+Upper Limb في الـBird والـBird والـHuman وشوفنا
+
+630
+01:10:37,260 --> 01:10:43,270
+تشابههم واختلافهممش غلط الواحد يحاول يدرس المادة
+
+631
+01:10:43,270 --> 01:10:50,630
+الورافية تبعتها الإنسان مميز، 46 من الـChromosome
+
+632
+01:10:50,630 --> 01:10:57,750
+22 من الـSomatic أو الـAutosomal
+
+633
+01:10:57,750 --> 01:11:04,130
+والـX والـY، الـSix Chromosomes هذا الترتيب، حكات
+
+634
+01:11:04,130 --> 01:11:15,530
+منه تقريبًااللي يعني يقارب 95%، 95% يعني الأرقام
+
+635
+01:11:15,530 --> 01:11:21,070
+متفاوتة قليلاً «Non-coding DNA» ليش قيمة الجزء
+
+636
+01:11:21,070 --> 01:11:26,030
+القليل هو فقط اللي فيه المادة الوراثية للإنسان
+
+637
+01:11:26,030 --> 01:11:32,230
+وحوالي 25، 22، 25 ألف جين الموجودة في الإنسان كمان
+
+638
+01:11:32,230 --> 01:11:39,630
+جينا ندرس زي الـ Drosophilaاللي هي دبابة الفاكهة
+
+639
+01:11:39,630 --> 01:11:47,050
+دبابة الفاكهة الـ DNA حوالي أربع جينات فقط أربع،
+
+640
+01:11:47,050 --> 01:11:52,830
+آسف، أربع كرومزومات فقط يعني المادة الوراثية عندها
+
+641
+01:11:52,830 --> 01:11:57,650
+لا يوجد بينها فواصل زي ما بنتوقع عند الإنسان
+
+642
+01:11:57,650 --> 01:12:02,350
+المغالبية العظمة مالوش قيمة وRepeats وعبارة عن
+
+643
+01:12:02,350 --> 01:12:10,100
+جانب مالوش قيمةهكذا يُظن فلما
+
+644
+01:12:10,100 --> 01:12:18,200
+نجينا نشوف الأشياء المسؤولة عن تطور أماكن معينة
+
+645
+01:12:18,200 --> 01:12:22,920
+هنا مثلًا حتى على تطور الجهاز العصبي مثلًا بالنسبة
+
+646
+01:12:22,920 --> 01:12:32,640
+لترتيبة الأمور تجد أن هناك نوع من التشابههنا الـ
+
+647
+01:12:32,640 --> 01:12:37,640
+Human أو الـ Mouse بيكون بشكل معين عدد الـ Repeats
+
+648
+01:12:37,640 --> 01:12:43,220
+بيكون الجينات المسؤولة عن جانب معين بيكون مختلف
+
+649
+01:12:43,220 --> 01:12:52,840
+والفكرة أنه لما نرى المنطقة اللي هي سيتم نقلة
+
+650
+01:12:52,840 --> 01:12:59,560
+لإعطائنا بروتين معين حتى يتم قراءة هذا الجزء ماشي
+
+651
+01:12:59,560 --> 01:13:06,960
+بشكل سليميجب أن تحدث وتتدخّل جوانب كثيرة جدًا من
+
+652
+01:13:06,960 --> 01:13:14,240
+قبل فالـ «هرمون» اللي سي .. أو الأسف الـ «إنزايم»
+
+653
+01:13:14,240 --> 01:13:20,320
+اللي راح يكون الـ «RNA» من الـ «DNA» اللي يعمل
+
+654
+01:13:20,320 --> 01:13:24,760
+عملية الـ Transcription، ماشي؟ نسمي الـ «RNA»
+
+655
+01:13:24,760 --> 01:13:31,170
+Polymeraseفالـ RNA Polymerase راح يجي على الـ DNA
+
+656
+01:13:31,170 --> 01:13:36,730
+وراح يشوف المكان اللي هيقوله ابدا وهي تسمى الـ
+
+657
+01:13:36,730 --> 01:13:41,330
+Promoter Region منطقة الـ Promoter اللي هي بتتحكم
+
+658
+01:13:41,330 --> 01:13:46,790
+في الـ Transcription تبعت الـ DNA للـ Coding
+
+659
+01:13:46,790 --> 01:13:51,290
+Region اللي بتعطينا الـ RNA Transcript نتيجة هذا
+
+660
+01:13:51,290 --> 01:13:57,710
+الإنزين حتى هذا الإنزين يشتغل لازم يكون فيه لهعلى
+
+661
+01:13:57,710 --> 01:14:01,250
+الـ «Promoter Region» «General Transcription
+
+662
+01:14:01,250 --> 01:14:08,510
+Factors» فيه مُركّبات حتى تؤمر الـ «RNA» أنه يبدأ
+
+663
+01:14:08,510 --> 01:14:12,010
+من هنا ويبدأ عملية الـ Transcription وفيه
+
+664
+01:14:12,010 --> 01:14:17,470
+Activators وفيه Coactivators وأحيانًا بيكون فيه
+
+665
+01:14:17,470 --> 01:14:20,070
+طبعًا هذا يجب أن نسميه «مناطق» على الـ «DNA
+
+666
+01:14:20,070 --> 01:14:26,050
+Enhancers» يعني كلها عشان تهيأ أنه يتم قراءة هذا
+
+667
+01:14:26,050 --> 01:14:30,360
+الجانبويكون أحيانًا فيه repressor يعني فيه
+
+668
+01:14:30,360 --> 01:14:37,080
+inhibitors حتى أحيانًا بتكون موجودة فالفكرة اللي
+
+669
+01:14:37,080 --> 01:14:42,840
+بدنا ناخدها أنه حتى بعد حياة الإنسان يعني بعد
+
+670
+01:14:42,840 --> 01:14:48,660
+ولاته أي protein بتتم تنشيطه وعمله في مرحلة معينة
+
+671
+01:14:48,660 --> 01:14:57,080
+البداية راح تكونعلى مستوى الـ DNA البداية هتكون
+
+672
+01:14:57,080 --> 01:15:03,260
+بنظام دقيق مع عوامل كثيرة تنشط أو تثبت أو تحدد
+
+673
+01:15:03,260 --> 01:15:09,500
+القراءة يعني أن إنتاج أي بروتين أو RNA في هذه
+
+674
+01:15:09,500 --> 01:15:16,340
+الحالة بالضبط ليس قضية عشوائية، ليست قضية ذاتية من
+
+675
+01:15:16,340 --> 01:15:23,060
+حالها إنما هناك أوامر تحدث لإنها تطلب منهاحتى تعمل
+
+676
+01:15:23,060 --> 01:15:33,220
+هذا الأمر الـ… الأن على يعني حتى من كائنات حية زي
+
+677
+01:15:33,220 --> 01:15:43,060
+الدبابة المنطقة الأمامية، المنطقة الـ… الـDistal،
+
+678
+01:15:43,060 --> 01:15:49,060
+Proximal، Posterior، Anterior يعني حتى في نمو
+
+679
+01:15:49,060 --> 01:15:55,070
+الإنسان ونمو هذه الكائناتما هو الشيء اللي سيكون في
+
+680
+01:15:55,070 --> 01:15:57,630
+الأمام؟ ما هو الشيء اللي سيكون في الخلف؟ ما هو الـ
+
+681
+01:15:57,630 --> 01:16:00,550
+«على اليمين»؟ «على اليسار»؟ «الأقرب للمنتصف»؟
+
+682
+01:16:00,550 --> 01:16:08,090
+«الأبعد للمنتصف»؟ كل هذه هناك محددات وعوامل تنشيط
+
+683
+01:16:08,090 --> 01:16:13,950
+لتدفع الخلايا باتجاه معين فمثل على ذلك بالنسبة
+
+684
+01:16:13,950 --> 01:16:21,450
+للعظام يعني هنا حاطين صور اختلالاتورافية في الـ
+
+685
+01:16:21,450 --> 01:16:30,730
+Development of Bones فهنا الـ HOXD13 عبارة عن
+
+686
+01:16:30,730 --> 01:16:37,870
+مجموعة جينات وظيفتها تنشط الله أعلم البروتين اللي
+
+687
+01:16:37,870 --> 01:16:42,750
+بتكون مسئولة عن إنتاجه بس خلل في هذا المناطق من
+
+688
+01:16:42,750 --> 01:16:48,810
+الـ DNA تجعل هناك مشاكلاليدين هؤلاء، هتين، يعني
+
+689
+01:16:48,810 --> 01:16:55,470
+هنا الإبام ملتصقة ببعض ولم تنفصل، لم تتطور بالشكل
+
+690
+01:16:55,470 --> 01:17:03,290
+السليم بالنسبة للمرض اللي هو Polycystic Kidney
+
+691
+01:17:03,290 --> 01:17:13,550
+Disease عبارة عن مرض ضمني في الكبار Exlingued
+
+692
+01:17:13,550 --> 01:17:14,210
+Recessive
+
+693
+01:17:19,510 --> 01:17:27,130
+وبكون المشكلة الأساسية فيه أن الكيلة
+
+694
+01:17:27,130 --> 01:17:32,970
+بالذات ولكن غيرها من الأعضاء بيكون فيها حوائي صلات
+
+695
+01:17:32,970 --> 01:17:38,930
+فالحوائي صلات هذه بتتضخم بشكل يضغط على باقية أنسجة
+
+696
+01:17:38,930 --> 01:17:43,990
+الكيلية بحيث يسبب فشل الكلوة الـ Polycystic Kidney
+
+697
+01:17:43,990 --> 01:17:47,840
+Disease بيعمل فشل الكلوةبس لأنه الكلة كبيرة ويظل
+
+698
+01:17:47,840 --> 01:17:51,860
+يطلع الـ Erythropoietin فمايكونش فيه أنيميا يعني
+
+699
+01:17:51,860 --> 01:17:58,600
+أنا من الأسئلة لطلاب الطب أو لطباء بقولهم إيش هو
+
+700
+01:17:58,600 --> 01:18:03,340
+إذا مريض عنده facial callaway بس دمه كويس، شوستة
+
+701
+01:18:03,340 --> 01:18:10,420
+طبعاً، facial callaway مزمن وليس حادث، فلازم تكون
+
+702
+01:18:10,420 --> 01:18:14,330
+الإجابة في الغالب Polycystic Kidney Diseaseفالـ
+
+703
+01:18:14,330 --> 01:18:20,110
+Polycystic Kidney Disease بيكون
+
+704
+01:18:20,110 --> 01:18:26,890
+الهويصيلات هذه موجودة في شرين الدماغ، في
+
+705
+01:18:26,890 --> 01:18:33,210
+البنكرياز، في أماكن أخرى، مش بس الكلا يعني فالآن
+
+706
+01:18:33,210 --> 01:18:37,270
+لقينا إنه إشي بيسموه الـ Epidermal Growth Factor
+
+707
+01:18:37,270 --> 01:18:44,670
+Receptor EGFRماشي هو اللي بيكون فيه اختلال
+
+708
+01:18:44,670 --> 01:18:51,350
+وبالتالي يعني لقينا الجين المسؤول عن هذه الظاهرة
+
+709
+01:18:51,350 --> 01:19:00,010
+فهنا جميل إن الواحد يكون قادر على من الحالة
+
+710
+01:19:00,010 --> 01:19:07,450
+بمرض بشكل معين أرجع أعمل دراسة وراثية وجينية
+
+711
+01:19:07,450 --> 01:19:12,650
+وألاقي اختلال في الجين معينوأحاول أفسر كيف هذا
+
+712
+01:19:12,650 --> 01:19:19,670
+الأمر حصل كذلك في قضية الحالة
+
+713
+01:19:19,670 --> 01:19:26,510
+نادرة من قضية اسمها «Lysencephaly» «Lysencephaly»
+
+714
+01:19:26,510 --> 01:19:33,030
+أو «Lysencephalitis» دا في التهابس الدماغ نفسه
+
+715
+01:19:33,030 --> 01:19:43,290
+فهنا في حاطين تفاصيل أكثر عن الأمراضبيكون الاختلال
+
+716
+01:19:43,290 --> 01:19:48,270
+إنه قشرة
+
+717
+01:19:48,270 --> 01:19:57,270
+الدماغ بتكون بشكل بنقول «سن» وبنقول «عش» عنه «ملس»
+
+718
+01:19:57,270 --> 01:20:04,750
+وليس متعرج، ماشي؟ فالـ «إنسان سفلي» بيكون خلل في
+
+719
+01:20:04,750 --> 01:20:11,430
+الـ «development» تبع الخلايا العصبيةوهذه أحيانًا
+
+720
+01:20:11,430 --> 01:20:18,510
+يعني إذا رأينا كيف الإنسان بيتطور فطبعًا
+
+721
+01:20:18,510 --> 01:20:22,450
+التطور لازم يكون حكينا في أشياء بتوجه الخلايا
+
+722
+01:20:22,450 --> 01:20:28,470
+بتروح للجهة الأمامية البطنية أو الجهة الطهرية أو
+
+723
+01:20:28,470 --> 01:20:36,710
+الجهة الـ Media الأنسية والـ الـ الـ شو بيسموها؟
+
+724
+01:20:36,710 --> 01:20:42,900
+يعنيMedial وLateral الـ Medial اللي هي الجهة
+
+725
+01:20:42,900 --> 01:20:48,580
+الأنسية والـ Lateral الجهة الوحشية يعني المتوحش
+
+726
+01:20:48,580 --> 01:20:54,580
+بعيدة يعني فتطور الخلايا وهجرتها باتجاه السليم
+
+727
+01:20:54,580 --> 01:20:59,760
+ترتيبها بالشكل السليم الإنسان الطبيعي قشرة الدماغ
+
+728
+01:20:59,760 --> 01:21:04,140
+والدماغ بيكون مرتب بشكل طبقات بيكون بهذا الشكل
+
+729
+01:21:04,140 --> 01:21:12,390
+وبهذا الترتيبلقينا إنه فيه هرمو أو جين معين اللي
+
+730
+01:21:12,390 --> 01:21:20,130
+هو LIS1 L-I-S-1 mutation بيسبب إن الخلايا بتعرفش
+
+731
+01:21:20,130 --> 01:21:25,090
+تروح وين فهيك بتتجعلك و بتتخربط و مابتنتقلش بالشكل
+
+732
+01:21:25,090 --> 01:21:29,730
+المنتضن السليم اللي بيعطينا النمو الطبيعي للجهاز
+
+733
+01:21:29,730 --> 01:21:37,850
+العصبيالـ Less than cephaly هو حالة نتيجة اختلال
+
+734
+01:21:37,850 --> 01:21:43,290
+في هرمون أو في جين معين اللي هو «Less than one»
+
+735
+01:21:43,290 --> 01:21:47,950
+وبكون نتيجته إن الخلايا ماعرفتش كيف اتهاجر و أين
+
+736
+01:21:47,950 --> 01:21:50,950
+اتهاجر، كيف اتهاجر بالشكل السليم في الـ
+
+737
+01:21:50,950 --> 01:21:57,670
+Development فهناك تفاصيل كثيرة وحالات يعني
+
+738
+01:22:01,840 --> 01:22:09,000
+متعددة من إمكانات حدوث الاختلالات
+
+739
+01:22:09,000 --> 01:22:17,660
+التطورية والعيوب الخلقية الـ Birth Defects فالآن
+
+740
+01:22:17,660 --> 01:22:25,140
+هناك محاولة فهم أكبر للمحددات لهجرة الخلايا أو
+
+741
+01:22:25,140 --> 01:22:30,910
+لتعامل الخلايا وهذه بتفيدنا كما بنقول دائماًالجانب
+
+742
+01:22:30,910 --> 01:22:37,790
+الأول في قضية معرفة فهم المرض والقضية الثانية في
+
+743
+01:22:37,790 --> 01:22:44,630
+معرفة فهم احتمالات الأدوية واحتمالات العلاجات
+
+744
+01:22:44,630 --> 01:22:49,890
+واحتمالات معالجة الحالات المختلفة الله يعطيكم
+
+745
+01:22:49,890 --> 01:22:51,090
+الأعافية، في أسئلة
+
+746
+01:23:00,010 --> 01:23:05,710
+إن شاء الله خير ونلتقي إن شاء الله الأسبوع القادم
+
+747
+01:23:05,710 --> 01:23:10,850
+يوم الأربعة أنتم عندكم امتحان يوم الأثنين القادم
+
+748
+01:23:10,850 --> 01:23:15,090
+إن شاء الله نلتقي ومش راح يكون محاضرة جديدة بقدر
+
+749
+01:23:15,090 --> 01:23:20,650
+ما هي مراجعة استعدادة للامتحان ماشي الله يعطيكم
+
+750
+01:23:20,650 --> 01:23:21,430
+العافية
+
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/w_288b1_4WQ_raw.json b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/w_288b1_4WQ_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..9e51d7a43c1dc32d838351cc327efccf1e61d8c0
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/w_288b1_4WQ_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 2756, "start": 0.0, "end": 27.56, "text": "الجميع من دخل معانا في المحاضرة ووفقكم الله بالنسبة إن أول المحاضرة دايماً اللي في حد عنده سؤال عن مواضيع السابقة مواضيع الامتحان ومش امتحان وشو بنسوه المرات الجاية عند الدكتور أحمد للشباب والدكتورات اللي موجودين", "tokens": [6027, 7435, 2304, 40228, 9154, 11778, 9778, 1211, 20449, 7649, 995, 8978, 9673, 5016, 46958, 25720, 4032, 38688, 4587, 24793, 21984, 20666, 1863, 35457, 3660, 36145, 5551, 12610, 9673, 5016, 46958, 25720, 11778, 47302, 15042, 14111, 13672, 1829, 8978, 11331, 3215, 43242, 3224, 8608, 33604, 6027, 18871, 3714, 2407, 46958, 40228, 21136, 16758, 28671, 3714, 2407, 46958, 40228, 2423, 10943, 2655, 5016, 7649, 4032, 2304, 8592, 1975, 2304, 2655, 5016, 7649, 4032, 8592, 2407, 44945, 3794, 2407, 3224, 9673, 2288, 9307, 25724, 995, 10632, 43242, 32748, 4117, 2655, 13063, 5551, 35571, 3215, 24976, 8592, 3555, 16758, 16070, 3215, 4117, 2655, 13063, 9307, 13672, 1829, 3714, 29245, 23328, 9957], 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"end": 10.82, "word": " المحاضرة", "probability": 0.8013916015625}, {"start": 10.82, "end": 11.48, "word": " دايماً", "probability": 0.733642578125}, {"start": 11.48, "end": 11.56, "word": " اللي", "probability": 0.5689697265625}, {"start": 11.56, "end": 11.7, "word": " في", "probability": 0.86328125}, {"start": 11.7, "end": 11.98, "word": " حد", "probability": 0.91455078125}, {"start": 11.98, "end": 12.36, "word": " عنده", "probability": 0.86328125}, {"start": 12.36, "end": 12.78, "word": " سؤال", "probability": 0.9920247395833334}, {"start": 12.78, "end": 13.02, "word": " عن", "probability": 0.986328125}, {"start": 13.02, "end": 13.44, "word": " مواضيع", "probability": 0.821044921875}, {"start": 13.44, "end": 14.3, "word": " السابقة", "probability": 0.9803059895833334}, {"start": 14.3, "end": 17.06, "word": " مواضيع", "probability": 0.939208984375}, {"start": 17.06, "end": 18.12, "word": " الامتحان", "probability": 0.9427734375}, {"start": 18.12, "end": 18.78, "word": " ومش", 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"probability": 0.9893798828125}], "temperature": 1.0}, {"id": 2, "seek": 5225, "start": 28.33, "end": 52.25, "text": "إذا حد عنده أسئلة في الوراثة إذا في حد عنده سؤال ممكن نبدأ نشرحه يعني دائما الأسئلة جيدة وبيشرح الواحد فيها في نقطة بشكل بتبتة عند الواحد اليوم", "tokens": [28814, 15730, 11331, 3215, 43242, 3224, 5551, 3794, 19986, 37977, 8978, 2423, 13063, 5718, 104, 3660, 11933, 15730, 8978, 11331, 3215, 43242, 3224, 8608, 33604, 6027, 3714, 43020, 8717, 44510, 10721, 8717, 46309, 5016, 3224, 37495, 22653, 11778, 16373, 15042, 16247, 3794, 19986, 37977, 10874, 25708, 3660, 4032, 21292, 46309, 5016, 2423, 14407, 24401, 8978, 11296, 8978, 8717, 47432, 3660, 4724, 8592, 28820, 39894, 3555, 2655, 3660, 43242, 2423, 14407, 24401, 45595, 20498], "avg_logprob": -0.18486064229462598, "compression_ratio": 1.773972602739726, "no_speech_prob": 0.0005517005920410156, "words": [{"start": 28.33, "end": 29.37, "word": "إذا", "probability": 0.94189453125}, {"start": 29.37, "end": 29.63, "word": " حد", "probability": 0.6544189453125}, {"start": 29.63, "end": 29.99, "word": " عنده", "probability": 0.97998046875}, {"start": 29.99, "end": 30.37, "word": " أسئلة", "probability": 0.992919921875}, {"start": 30.37, "end": 30.59, "word": " في", "probability": 0.93896484375}, {"start": 30.59, "end": 31.83, "word": " الوراثة", "probability": 0.769580078125}, {"start": 31.83, "end": 35.39, "word": " إذا", "probability": 0.917236328125}, {"start": 35.39, "end": 35.59, "word": " في", "probability": 0.65380859375}, {"start": 35.59, "end": 35.89, "word": " حد", "probability": 0.961669921875}, {"start": 35.89, "end": 36.27, "word": " عنده", "probability": 0.96240234375}, {"start": 36.27, "end": 36.59, "word": " سؤال", "probability": 0.99560546875}, {"start": 36.59, "end": 37.07, "word": " ممكن", "probability": 0.87353515625}, {"start": 37.07, "end": 37.75, "word": " نبدأ", "probability": 0.9847005208333334}, {"start": 37.75, "end": 38.53, "word": " نشرحه", "probability": 0.977783203125}, 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"probability": 0.9586588541666666}, {"start": 76.1, "end": 77.78, "word": " بالنسبة", "probability": 0.90478515625}, {"start": 77.78, "end": 79.16, "word": " لقضية", "probability": 0.9801025390625}, {"start": 79.16, "end": 80.84, "word": " الـ", "probability": 0.960205078125}, {"start": 80.84, "end": 81.22, "word": " Human", "probability": 0.490478515625}, {"start": 81.22, "end": 81.8, "word": " أو", "probability": 0.9521484375}, {"start": 81.8, "end": 81.96, "word": " الـ", "probability": 0.788330078125}, {"start": 81.96, "end": 82.9, "word": " Developmental", "probability": 0.8017578125}, {"start": 82.9, "end": 83.54, "word": " Genetics", "probability": 0.854248046875}, {"start": 83.54, "end": 84.08, "word": " أنبعاث", "probability": 0.562353515625}, {"start": 84.08, "end": 84.74, "word": " التفكير", "probability": 0.75341796875}], "temperature": 1.0}, {"id": 4, "seek": 11304, "start": 88.04, "end": 113.04, "text": "يعني هذا موضوع يعني شغل الأولماء وهناك يعني جوانب في تطور الإنسان 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"probability": 0.6002197265625}, {"start": 914.06, "end": 914.36, "word": " من", "probability": 0.89404296875}, {"start": 914.36, "end": 915.1, "word": " قضية", "probability": 0.9920247395833334}, {"start": 915.1, "end": 915.66, "word": " ولادة", "probability": 0.810302734375}, {"start": 915.66, "end": 916.22, "word": " أطفال", "probability": 0.9931640625}, {"start": 916.22, "end": 917.1, "word": " مشوهين", "probability": 0.950439453125}, {"start": 917.1, "end": 917.78, "word": " بلا", "probability": 0.92236328125}, {"start": 917.78, "end": 918.4, "word": " أطراف", "probability": 0.9696044921875}, {"start": 918.4, "end": 919.96, "word": " فثبت", "probability": 0.8519287109375}, {"start": 919.96, "end": 920.44, "word": " بعدين", "probability": 0.93505859375}, {"start": 920.44, "end": 920.66, "word": " إن", "probability": 0.67138671875}, {"start": 920.66, "end": 921.02, "word": " هذا", "probability": 0.8369140625}, {"start": 921.02, "end": 921.24, "word": " هو", "probability": 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935.16, "end": 935.74, "word": "الآن", "probability": 0.7332356770833334}, {"start": 935.74, "end": 936.06, "word": " الـ", "probability": 0.793212890625}, {"start": 936.06, "end": 936.98, "word": " Thalidomide", "probability": 0.747802734375}, {"start": 936.98, "end": 937.44, "word": " هو", "probability": 0.8388671875}, {"start": 937.44, "end": 938.0, "word": " دوة", "probability": 0.8409830729166666}, {"start": 938.0, "end": 939.02, "word": " حكينا", "probability": 0.80645751953125}, {"start": 939.02, "end": 939.76, "word": " أنه", "probability": 0.7012939453125}, {"start": 939.76, "end": 940.82, "word": " قوى", "probability": 0.7161458333333334}, {"start": 940.82, "end": 941.34, "word": " جداً", "probability": 0.8544921875}, {"start": 941.34, "end": 941.98, "word": " وكويس", "probability": 0.9161376953125}, {"start": 941.98, "end": 943.68, "word": " ضد", "probability": 0.980224609375}, {"start": 943.68, "end": 946.42, "word": " الغثيان", "probability": 0.9443359375}, {"start": 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956.14, "end": 957.0, "word": " قليلة", "probability": 0.9837239583333334}, {"start": 957.0, "end": 957.24, "word": " من", "probability": 0.9873046875}], "temperature": 1.0}, {"id": 34, "seek": 98469, "start": 957.99, "end": 984.69, "text": "مثلًا حالات متقدمة من السلطان وفيها رثيان واستفرار في بعض الحالات الأخرى للأن يُستخدم فالـ Thalidomide هو الـ «تيراتوجين» وإله قصته ويعني أنا أظن أنه حتى يعني في الثقافة العامة عند الناس يعني بالذات أول الحمل الأصل", "tokens": [2304, 12984, 1211, 14111, 995, 11331, 6027, 9307, 44650, 28543, 46007, 9154, 21136, 1211, 9566, 7649, 4032, 41185, 11296, 12602, 12984, 1829, 7649, 36764, 14851, 5172, 2288, 9640, 8978, 45030, 11242, 21542, 6027, 9307, 16247, 34740, 7578, 5296, 1211, 10721, 1863, 7251, 10859, 14851, 9778, 40448, 6156, 6027, 39184, 334, 31509, 298, 482, 31439, 2423, 39184, 4657, 2655, 13546, 9307, 29245, 9957, 5933, 4032, 28814, 43761, 12174, 9381, 47395, 4032, 40228, 22653, 41850, 5551, 19913, 1863, 14739, 3224, 11331, 49975, 37495, 22653, 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عنها A وB وC Class A وClass B وClass C Class A هو دوة ثبت أمنه وثبت فائدته يعني إنه لا يسبب أي تأثير سلبي على الحمل Class C يعني ممنوع وثبت إنه مضر Class B", "tokens": [1829, 10859, 4587, 6027, 18871, 11296, 316, 4032, 33, 4032, 34, 9471, 316, 4032, 44621, 363, 4032, 44621, 383, 9471, 316, 31439, 11778, 2407, 3660, 38637, 3555, 2655, 5551, 27842, 3224, 4032, 12984, 3555, 2655, 6156, 16373, 3215, 47395, 37495, 22653, 36145, 3224, 20193, 7251, 35457, 3555, 36632, 6055, 10721, 12984, 13546, 8608, 1211, 21292, 15844, 21542, 42213, 9471, 383, 37495, 22653, 3714, 27842, 45367, 4032, 12984, 3555, 2655, 36145, 3224, 3714, 11242, 2288, 9471, 363], "avg_logprob": -0.12337662337662338, "compression_ratio": 1.6143790849673203, "no_speech_prob": 7.152557373046875e-07, "words": [{"start": 1012.72, "end": 1013.92, "word": "يُقال", "probability": 0.7489013671875}, {"start": 1013.92, "end": 1014.36, "word": " عنها", "probability": 0.995361328125}, {"start": 1014.36, "end": 1014.7, "word": " A", 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"seek": 495016, "start": 4921.84, "end": 4950.16, "text": "متعددة من إمكانات حدوث الاختلالات التطورية والعيوب الخلقية الـ Birth Defects فالآن هناك محاولة فهم أكبر للمحددات لهجرة الخلايا أو لتعامل الخلايا وهذه بتفيدنا كما بنقول دائماً", "tokens": [2304, 2655, 22488, 41891, 9154, 11933, 2304, 41361, 9307, 11331, 3215, 2407, 12984, 2423, 47283, 2655, 1211, 6027, 9307, 16712, 9566, 13063, 10632, 16070, 3615, 1829, 37746, 33962, 1211, 4587, 10632, 2423, 39184, 24299, 1346, 1836, 82, 6156, 6027, 148, 48506, 34105, 4117, 3714, 5016, 995, 12610, 3660, 6156, 16095, 5551, 4117, 26890, 5296, 19528, 24401, 3215, 9307, 46740, 7435, 25720, 33962, 15040, 25528, 34051, 5296, 2655, 3615, 10943, 1211, 33962, 15040, 25528, 37037, 24192, 39894, 5172, 25708, 8315, 9122, 15042, 44945, 39648, 11778, 16373, 15042, 14111], "avg_logprob": -0.14604048871181227, "compression_ratio": 1.597938144329897, "no_speech_prob": 2.980232238769531e-07, "words": [{"start": 4921.84, "end": 4923.24, "word": "متعددة", "probability": 0.8792724609375}, {"start": 4923.24, "end": 4923.68, "word": " من", "probability": 0.908203125}, {"start": 4923.68, "end": 4924.52, "word": " إمكانات", "probability": 0.8551025390625}, {"start": 4924.52, "end": 4925.32, "word": " حدوث", "probability": 0.868896484375}, {"start": 4925.32, "end": 4929.0, "word": " الاختلالات", "probability": 0.838623046875}, {"start": 4929.0, "end": 4930.24, "word": " التطورية", "probability": 0.9495849609375}, {"start": 4930.24, "end": 4932.7, "word": " والعيوب", "probability": 0.876708984375}, {"start": 4932.7, "end": 4933.6, "word": " الخلقية", "probability": 0.9915771484375}, {"start": 4933.6, "end": 4934.46, "word": " الـ", "probability": 0.798583984375}, {"start": 4934.46, "end": 4934.72, "word": " Birth", "probability": 0.402099609375}, {"start": 4934.72, "end": 4935.46, "word": " Defects", "probability": 0.8289388020833334}, {"start": 4935.46, "end": 4937.66, "word": " فالآن", "probability": 0.6217041015625}, {"start": 4937.66, "end": 4938.56, "word": " هناك", "probability": 0.93994140625}, {"start": 4938.56, "end": 4939.94, "word": " محاولة", "probability": 0.98994140625}, {"start": 4939.94, "end": 4940.4, "word": " فهم", "probability": 0.800048828125}, {"start": 4940.4, "end": 4941.58, "word": " أكبر", "probability": 0.9816080729166666}, {"start": 4941.58, "end": 4943.7, "word": " للمحددات", "probability": 0.92529296875}, {"start": 4943.7, "end": 4944.24, "word": " لهجرة", "probability": 0.9501953125}, {"start": 4944.24, "end": 4944.92, "word": " الخلايا", "probability": 0.9485677083333334}, {"start": 4944.92, "end": 4945.14, "word": " أو", "probability": 0.89404296875}, {"start": 4945.14, "end": 4945.76, "word": " لتعامل", "probability": 0.9392578125}, {"start": 4945.76, "end": 4946.4, "word": " الخلايا", "probability": 0.9793294270833334}, {"start": 4946.4, "end": 4947.58, "word": " وهذه", "probability": 0.77490234375}, {"start": 4947.58, "end": 4948.78, "word": " بتفيدنا", "probability": 0.88427734375}, {"start": 4948.78, "end": 4949.06, "word": " كما", "probability": 0.96142578125}, {"start": 4949.06, "end": 4949.5, "word": " بنقول", "probability": 0.807373046875}, {"start": 4949.5, "end": 4950.16, "word": " دائماً", "probability": 0.82958984375}], "temperature": 1.0}, {"id": 177, "seek": 497109, "start": 4950.43, "end": 4971.09, "text": "الجانب الأول في قضية معرفة فهم المرض والقضية الثانية في معرفة فهم احتمالات الأدوية واحتمالات العلاجات واحتمالات معالجة الحالات المختلفة الله يعطيكم الأعافية، في أسئلة", "tokens": [6027, 7435, 7649, 3555, 16247, 12610, 8978, 12174, 11242, 10632, 20449, 28480, 3660, 6156, 16095, 9673, 43042, 16070, 4587, 11242, 10632, 6024, 104, 7649, 10632, 8978, 20449, 28480, 3660, 6156, 16095, 1975, 33753, 2304, 6027, 9307, 16247, 3215, 2407, 10632, 36764, 33753, 2304, 6027, 9307, 18863, 1211, 26108, 9307, 36764, 33753, 2304, 6027, 9307, 20449, 6027, 7435, 3660, 21542, 6027, 9307, 9673, 46456, 46538, 3660, 21984, 37495, 9566, 1829, 24793, 16247, 3615, 31845, 10632, 12399, 8978, 5551, 3794, 19986, 37977], "avg_logprob": -0.07952353100717803, "compression_ratio": 2.081081081081081, "no_speech_prob": 2.1457672119140625e-06, "words": [{"start": 4950.43, "end": 4950.91, "word": "الجانب", "probability": 0.8671875}, {"start": 4950.91, "end": 4951.41, "word": " الأول", "probability": 0.993408203125}, {"start": 4951.41, "end": 4951.71, "word": " في", "probability": 0.93408203125}, {"start": 4951.71, "end": 4952.45, "word": " قضية", "probability": 0.8951822916666666}, {"start": 4952.45, "end": 4954.55, "word": " معرفة", "probability": 0.9762369791666666}, {"start": 4954.55, "end": 4954.91, "word": " فهم", "probability": 0.9833984375}, {"start": 4954.91, "end": 4955.45, "word": " المرض", "probability": 0.9931640625}, {"start": 4955.45, "end": 4956.83, "word": " والقضية", "probability": 0.916748046875}, {"start": 4956.83, "end": 4957.47, "word": " الثانية", "probability": 0.9742431640625}, {"start": 4957.47, "end": 4957.79, "word": " في", "probability": 0.96533203125}, {"start": 4957.79, "end": 4958.57, "word": " معرفة", "probability": 0.9964192708333334}, {"start": 4958.57, "end": 4959.43, "word": " فهم", "probability": 0.986083984375}, {"start": 4959.43, "end": 4961.97, "word": " احتمالات", "probability": 0.9564453125}, {"start": 4961.97, "end": 4962.77, "word": " الأدوية", "probability": 0.9927978515625}, {"start": 4962.77, "end": 4963.71, "word": " واحتمالات", "probability": 0.91220703125}, {"start": 4963.71, "end": 4964.63, "word": " العلاجات", "probability": 0.9051513671875}, {"start": 4964.63, "end": 4965.75, "word": " واحتمالات", "probability": 0.957421875}, {"start": 4965.75, "end": 4967.19, "word": " معالجة", "probability": 0.986572265625}, {"start": 4967.19, "end": 4967.75, "word": " الحالات", "probability": 0.9923502604166666}, {"start": 4967.75, "end": 4969.01, "word": " المختلفة", "probability": 0.9945068359375}, {"start": 4969.01, "end": 4969.39, "word": " الله", "probability": 0.66455078125}, {"start": 4969.39, "end": 4969.89, "word": " يعطيكم", "probability": 0.9608154296875}, {"start": 4969.89, "end": 4970.49, "word": " الأعافية،", "probability": 0.740234375}, {"start": 4970.49, "end": 4970.61, "word": " في", "probability": 0.70361328125}, {"start": 4970.61, "end": 4971.09, "word": " أسئلة", "probability": 0.96044921875}], "temperature": 1.0}, {"id": 178, "seek": 500143, "start": 4980.01, "end": 5001.43, "text": "إن شاء الله خير ونلتقي إن شاء الله الأسبوع القادم يوم الأربعة أنتم عندكم امتحان يوم الأثنين القادم إن شاء الله نلتقي ومش راح يكون محاضرة جديدة بقدر ما هي مراجعة استعدادة للامتحان ماشي الله يعطيكم العافية", "tokens": [28814, 1863, 13412, 16606, 21984, 16490, 13546, 4032, 1863, 1211, 2655, 38436, 36145, 13412, 16606, 21984, 16247, 35457, 45367, 25062, 18513, 2304, 7251, 20498, 16247, 25513, 27884, 14739, 39237, 43242, 24793, 1975, 2304, 2655, 5016, 7649, 7251, 20498, 16247, 12984, 1863, 9957, 25062, 18513, 2304, 36145, 13412, 16606, 21984, 8717, 1211, 2655, 38436, 4032, 2304, 8592, 12602, 39319, 7251, 30544, 3714, 5016, 46958, 25720, 10874, 16254, 41891, 4724, 28543, 2288, 19446, 39896, 3714, 2288, 26108, 27884, 44713, 22488, 18513, 3660, 24976, 10943, 2655, 5016, 7649, 3714, 33599, 1829, 21984, 37495, 9566, 1829, 24793, 18863, 31845, 10632], "avg_logprob": -0.13345682498106023, "compression_ratio": 2.021857923497268, "no_speech_prob": 0.000988006591796875, "words": [{"start": 4980.01, "end": 4981.09, "word": "إن", "probability": 0.410888671875}, {"start": 4981.09, "end": 4981.33, "word": " شاء", "probability": 0.9755859375}, {"start": 4981.33, "end": 4981.51, "word": " الله", "probability": 0.96826171875}, {"start": 4981.51, "end": 4982.13, "word": " خير", "probability": 0.83837890625}, {"start": 4982.13, "end": 4983.85, "word": " ونلتقي", "probability": 0.933203125}, {"start": 4983.85, "end": 4984.09, "word": " إن", "probability": 0.8818359375}, {"start": 4984.09, "end": 4984.25, "word": " شاء", "probability": 0.991943359375}, {"start": 4984.25, "end": 4984.49, "word": " الله", "probability": 0.9521484375}, {"start": 4984.49, "end": 4985.05, "word": " الأسبوع", "probability": 0.7250569661458334}, {"start": 4985.05, "end": 4985.71, "word": " القادم", "probability": 0.9944661458333334}, {"start": 4985.71, "end": 4986.41, "word": " يوم", "probability": 0.9033203125}, {"start": 4986.41, "end": 4987.03, "word": " الأربعة", "probability": 0.8444010416666666}, {"start": 4987.03, "end": 4987.57, "word": " أنتم", "probability": 0.72314453125}, {"start": 4987.57, "end": 4987.99, "word": " عندكم", "probability": 0.908203125}, {"start": 4987.99, "end": 4988.63, "word": " امتحان", "probability": 0.93603515625}, {"start": 4988.63, "end": 4989.65, "word": " يوم", "probability": 0.850341796875}, {"start": 4989.65, "end": 4990.31, "word": " الأثنين", "probability": 0.8985595703125}, {"start": 4990.31, "end": 4990.85, "word": " القادم", "probability": 0.9890950520833334}, {"start": 4990.85, "end": 4991.05, "word": " إن", "probability": 0.8310546875}, {"start": 4991.05, "end": 4991.17, "word": " شاء", "probability": 0.993408203125}, {"start": 4991.17, "end": 4991.39, "word": " الله", "probability": 0.966796875}, {"start": 4991.39, "end": 4992.11, "word": " نلتقي", "probability": 0.970703125}, {"start": 4992.11, "end": 4993.21, "word": " ومش", "probability": 0.86572265625}, {"start": 4993.21, "end": 4993.39, "word": " راح", "probability": 0.944580078125}, {"start": 4993.39, "end": 4993.69, "word": " يكون", "probability": 0.982177734375}, {"start": 4993.69, "end": 4994.19, "word": " محاضرة", "probability": 0.9847412109375}, {"start": 4994.19, "end": 4994.63, "word": " جديدة", "probability": 0.9939778645833334}, {"start": 4994.63, "end": 4995.09, "word": " بقدر", "probability": 0.9368489583333334}, {"start": 4995.09, "end": 4995.23, "word": " ما", "probability": 0.9736328125}, {"start": 4995.23, "end": 4995.39, "word": " هي", "probability": 0.97802734375}, {"start": 4995.39, "end": 4996.07, "word": " مراجعة", "probability": 0.973876953125}, {"start": 4996.07, "end": 4996.91, "word": " استعدادة", "probability": 0.84771728515625}, {"start": 4996.91, "end": 4997.95, "word": " للامتحان", "probability": 0.95732421875}, {"start": 4997.95, "end": 4999.07, "word": " ماشي", "probability": 0.787353515625}, {"start": 4999.07, "end": 5000.15, "word": " الله", "probability": 0.5146484375}, {"start": 5000.15, "end": 5000.65, "word": " يعطيكم", "probability": 0.979736328125}, {"start": 5000.65, "end": 5001.43, "word": " العافية", "probability": 0.8885091145833334}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 5024.17125, "duration_after_vad": 4855.572218750005}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/w_288b1_4WQ_raw.srt b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/w_288b1_4WQ_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..6d392a2b5afc310cba27bc8aa6907474f87c5a88
--- /dev/null
+++ b/PL9fwy3NUQKwYULQ2HRftIaOGdR-auLd9b/w_288b1_4WQ_raw.srt
@@ -0,0 +1,3001 @@
+1
+00:00:00,000 --> 00:00:05,920
+الجميع من دخل معانا في المحاضرة ووفقكم الله
+
+2
+00:00:05,920 --> 00:00:09,040
+بالنسبة
+
+3
+00:00:09,040 --> 00:00:13,020
+إن أول المحاضرة دايماً اللي في حد عنده سؤال عن
+
+4
+00:00:13,020 --> 00:00:19,780
+مواضيع السابقة مواضيع الامتحان ومش امتحان وشو
+
+5
+00:00:19,780 --> 00:00:25,600
+بنسوه المرات الجاية عند الدكتور أحمد للشباب
+
+6
+00:00:25,600 --> 00:00:30,590
+والدكتورات اللي موجودينإذا حد عنده أسئلة في
+
+7
+00:00:30,590 --> 00:00:35,390
+الوراثة إذا
+
+8
+00:00:35,390 --> 00:00:40,190
+في حد عنده سؤال ممكن نبدأ نشرحه يعني دائما الأسئلة
+
+9
+00:00:40,190 --> 00:00:47,190
+جيدة وبيشرح الواحد فيها في نقطة بشكل بتبتة عند
+
+10
+00:00:47,190 --> 00:00:52,250
+الواحد اليوم
+
+11
+00:00:57,360 --> 00:01:04,440
+فاحنا نتكلم إن شاء الله عن موضوع آخر ماشي،
+
+12
+00:01:04,440 --> 00:01:12,400
+كأنه فيه سؤال كرمل؟
+
+13
+00:01:12,400 --> 00:01:16,100
+طيب
+
+14
+00:01:16,100 --> 00:01:22,900
+بالنسبة لقضية الـ Human أو الـ Developmental
+
+15
+00:01:22,900 --> 00:01:24,740
+Genetics أنبعاث التفكير
+
+16
+00:01:28,040 --> 00:01:33,340
+يعني هذا موضوع يعني
+
+17
+00:01:33,340 --> 00:01:42,420
+شغل الأولماء وهناك يعني جوانب
+
+18
+00:01:42,420 --> 00:01:49,900
+في تطور الإنسان وخلق الإنسان وبعد ذلك حدوث
+
+19
+00:01:49,900 --> 00:02:00,190
+اختلالات معينة بشكليعني بانقسام غريب مهير للإنتباه
+
+20
+00:02:00,190 --> 00:02:09,330
+وهذه يعني يتم دراستها في عالمة مصرية في الخمسينات
+
+21
+00:02:09,330 --> 00:02:15,790
+والستينات من أقوى من قام بدراسة الاختلالات
+
+22
+00:02:15,790 --> 00:02:24,690
+التطورية في ذات الإيدين والرجلين وطريقةالاختلال
+
+23
+00:02:24,690 --> 00:02:32,110
+أنا يعني إذا بدي إشي من هالصورة اللي قدامنا بديش
+
+24
+00:02:32,110 --> 00:02:32,430
+اسم
+
+25
+00:02:32,430 --> 00:02:48,890
+الـ’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’
+
+26
+00:02:49,710 --> 00:02:56,890
+تخيل أو متباهة
+
+27
+00:02:56,890 --> 00:03:02,230
+لقضية ما يحصل أو ما هو الخلل هنا أو ما يسميها
+
+28
+00:03:02,230 --> 00:03:07,490
+فالطفل هذا اللي عنده سبع أصابع هذا اسمه
+
+29
+00:03:07,490 --> 00:03:13,770
+polydactyly axial polydactyly poly يعني أكتر،
+
+30
+00:03:13,770 --> 00:03:22,960
+dactyly اللي هي يعني قضية الأصابعماشي و «severe
+
+31
+00:03:22,960 --> 00:03:28,960
+cutaneous syndectomy» «سن» يعني مجموع مع بعضه
+
+32
+00:03:28,960 --> 00:03:32,200
+فالأصابع
+
+33
+00:03:32,200 --> 00:03:40,860
+بشكل جلدي مجموعات على بعض وفي اختلال في تطور هذا
+
+34
+00:03:40,860 --> 00:03:47,200
+الجنين وهذا الإنسان إنه الأصابع ماكنتش بالشكل
+
+35
+00:03:47,200 --> 00:03:55,570
+المفصول اللي احنا نتوقعهفهذه اختلالات تطورية وهذه
+
+36
+00:03:55,570 --> 00:04:04,510
+يعني اكتشفنا بعدين إنه الجينات والعوامل الوراثية
+
+37
+00:04:04,510 --> 00:04:13,670
+بتكون بتتحكم بهذا الأمر فقضية إنه يعني معرفة هذه
+
+38
+00:04:13,670 --> 00:04:22,160
+الجينات وسببهافي حدوث هذا المظهر، هذا الشكل دورها
+
+39
+00:04:22,160 --> 00:04:27,460
+يعني في قضية تطور الأطراف، تطور الأصابع، تطور
+
+40
+00:04:27,460 --> 00:04:35,380
+الحلق، التم، الدنين، الرجلين، التطور أي جانب قضية
+
+41
+00:04:35,380 --> 00:04:40,920
+بدها دراسة وبدالواحد يكون على اقتلاعها فهنا طبعاً
+
+42
+00:04:42,810 --> 00:04:49,830
+يعني كلمة أسماء نفس
+
+43
+00:04:49,830 --> 00:04:56,950
+الـSyndromes بحد ذاتهم ماشي ما أظن يعني حتى ولو في
+
+44
+00:04:56,950 --> 00:05:02,370
+الـUS أملي أو في غيرها من الأسئلة بهمهم الواحد
+
+45
+00:05:02,370 --> 00:05:09,030
+يعني بحد ذاته اسم المرض بقدر ما أنه كمان الواحد
+
+46
+00:05:09,030 --> 00:05:16,200
+يعني يستخدم الاسم هذابتذكر مجموعة الأعراض
+
+47
+00:05:16,200 --> 00:05:20,680
+الموجودة كيف بتكون وهم ذلك بالذات الأشياء اللي
+
+48
+00:05:20,680 --> 00:05:28,720
+فيها تبت أمور جينية ورافية أنه الواحد يشوف شو الـ…
+
+49
+00:05:28,720 --> 00:05:35,800
+الـMutation وين موجودة في أي جين وليش بيعمل هذا
+
+50
+00:05:35,800 --> 00:05:40,600
+الاشي والقضايا هذه الـ
+
+51
+00:05:41,110 --> 00:05:48,090
+هنا إشي اسمه يعني congenital arthrogyropsis
+
+52
+00:06:28,550 --> 00:06:35,130
+السلام عليكم، شكله انقطع، ما أعرف، فالحال
+
+53
+00:06:35,130 --> 00:06:40,350
+هنا اللي
+
+54
+00:06:40,350 --> 00:06:49,010
+بيفرجونيا بالنسبة للصورة
+
+55
+00:06:49,010 --> 00:06:51,870
+الحديث الولاد هذا الـ Newborn هذا
+
+56
+00:06:54,730 --> 00:06:59,230
+دكتور، بعد ذلك بستعمل share للشاشة اللي ليه مش
+
+57
+00:06:59,230 --> 00:07:11,490
+مبينة أه أه أه، لأنه ما طلعني أهي، أين راحت؟
+
+58
+00:07:27,960 --> 00:07:35,380
+بقول هنا في صورة يعني
+
+59
+00:07:35,380 --> 00:07:43,060
+still birth يعني ولادة جنين ميت الاختلالات
+
+60
+00:07:43,060 --> 00:07:52,080
+الموجودة إنه كان الحمل حوالين الجنين السائل
+
+61
+00:07:52,080 --> 00:07:57,660
+الأمنيوثي أو الـ Ammoniotic Fluid كان قليل جداً
+
+62
+00:07:58,130 --> 00:08:05,930
+وكمان نتيجة اختلال في العضلات أصبح هناك شد شديد
+
+63
+00:08:05,930 --> 00:08:14,930
+وعدم فاعلية في … عدم
+
+64
+00:08:14,930 --> 00:08:22,350
+فاعلية بالنسبة للعضلات وبالتالي المفاصل كانت
+
+65
+00:08:22,350 --> 00:08:28,070
+يعني مضروبة بشكلزي هيك يعني الإيد مش مفتوحة الرجل
+
+66
+00:08:28,070 --> 00:08:34,850
+مش مفتوحة والشكل هذا هنا يعني قضية إنه مايكنش فيه
+
+67
+00:08:34,850 --> 00:08:42,710
+سائل حوالين الجنين أحيانًا بيكون نتيجة مشاكل في
+
+68
+00:08:42,710 --> 00:08:47,710
+الـ يعني غالبية السائل اللي حوالين الحمل هو من الـ
+
+69
+00:08:47,710 --> 00:08:51,350
+ball تبع نفس الجنين يعني بالإضاءة للإفرازات
+
+70
+00:08:51,350 --> 00:08:57,550
+المشيمة أو أشياء تانيةفلما ما يكونش موجود أحيانًا
+
+71
+00:08:57,550 --> 00:09:04,330
+بيكون مؤشر على مثلًا فشل كلوي في الجنين، عدم
+
+72
+00:09:04,330 --> 00:09:10,750
+إمكانية إفراز البول، وده ولد بشكل طبيعي، يعني
+
+73
+00:09:10,750 --> 00:09:18,710
+قدرنا يوصل لحد أن يكون بعد ذلك يولد بشكل طبيعي، هو
+
+74
+00:09:18,710 --> 00:09:25,720
+نحطي ملاحظة على الحالة هذهإنه في هذه الحالة الدكاء
+
+75
+00:09:25,720 --> 00:09:32,120
+والتطور العقلي العصبي كان طبيعي وإنه بس بده شغل
+
+76
+00:09:32,120 --> 00:09:39,740
+على عمليات وبالنسبة لعلاج
+
+77
+00:09:39,740 --> 00:09:49,180
+طبيعي للجوانب العظام يعني فلما نلاقي الإنسان عنده
+
+78
+00:09:51,700 --> 00:09:59,880
+يعني مشاكل الجانب الأهم لقضية إنه هل هذا مشكلة
+
+79
+00:09:59,880 --> 00:10:05,080
+ويراثية ولا لأ لما نجد الإنسان حالة أو عائلة بمثل
+
+80
+00:10:05,080 --> 00:10:12,080
+هذا الشكل بنتبه إن الحالة الوراثية بدي تكون أكثر
+
+81
+00:10:12,080 --> 00:10:15,900
+من فرد في العائلة مصاب يعني إن هذه شغل الواحد بده
+
+82
+00:10:15,900 --> 00:10:24,740
+يدور عليها أو يشوفهاوبدّو يحاول يعني ينتبه لها
+
+83
+00:10:24,740 --> 00:10:27,820
+فأنا
+
+84
+00:10:27,820 --> 00:10:38,680
+بحاول أن أنزل هنا
+
+85
+00:10:38,680 --> 00:10:47,160
+في أحيانًا أحداث يعني أنا بظن بعد ذلك
+
+86
+00:10:51,080 --> 00:11:01,260
+بيحاولوا يتكلموا عنها أنه لما نشوف حالات وراثية أو
+
+87
+00:11:01,260 --> 00:11:08,340
+يعني اللي هي أكتر من فرد في العائلة ونحاول
+
+88
+00:11:08,340 --> 00:11:17,980
+نشوف الأمراض الناتجة عنهاسواء في عائلة معينة أو في
+
+89
+00:11:17,980 --> 00:11:27,460
+مجتمع نجي نعمل دراسة بنلاقي إنه 20% تقريبًا بيكون
+
+90
+00:11:27,460 --> 00:11:33,400
+سببها Single-Gene Defect يعني هذه اللي هي من
+
+91
+00:11:33,400 --> 00:11:39,200
+المسببات للـ Developmental Malformations الـ
+
+92
+00:11:39,200 --> 00:11:48,460
+Developmental Anomalies بنلاقي إنهإن يكون سببها
+
+93
+00:11:48,460 --> 00:11:54,940
+فقط جين واحد هذا بيكون تقريبًا بنسبة عشرين بالمية
+
+94
+00:11:54,940 --> 00:12:05,780
+تقريبًا أحيانًا في هناك اختلالات تراثية أخرى زي
+
+95
+00:12:05,780 --> 00:12:11,880
+copy number variants في جين معين مش شغلة Mendelian
+
+96
+00:12:11,880 --> 00:12:16,410
+inheritanceالـ Copy مضروبة أو الـ Copy طبيعية
+والـ
+
+97
+00:12:16,410 --> 00:12:20,910
+Copy المضروبة هي اللي أعطت المرض، لأ بيكون حالات
+
+98
+00:12:20,910 --> 00:12:26,010
+أخرى مجموعة من الـ يعني وفي صورة عنها حتى جزء منها
+
+99
+00:12:26,010 --> 00:12:31,770
+موجود في الكائنات الأخرى مثلًا وانا راح اتكلم عنها
+
+100
+00:12:31,770 --> 00:12:37,610
+ببابة الـ Drosophila أو غيرها أو كده ففي مرات وجود
+
+101
+00:12:37,610 --> 00:12:43,300
+أكتر منالنسخة أو عدد النسخ الموجودة بالنسبة لجين
+
+102
+00:12:43,300 --> 00:12:49,780
+معين فيه هناك أحيانًا 25% كروموزوم الـ anomalies
+
+103
+00:12:49,780 --> 00:12:55,860
+فهذه تتكلم تقريبًا الواحد على ربع الحالات ويكون
+
+104
+00:12:55,860 --> 00:13:02,120
+على مستوى قطعة كبيرة من الـDNA فالكروموزوم بأكمله
+
+105
+00:13:02,120 --> 00:13:07,200
+ممكن يكون فيه اختلال وممكن قطعة كبيرة في
+
+106
+00:13:07,200 --> 00:13:13,700
+الكروموزومزي ما حكينا مرات في بعض الحالات بتكون
+
+107
+00:13:13,700 --> 00:13:19,760
+باند كبير، خطعة كبيرة يعني بتكون فيها عدد كبير من
+
+108
+00:13:19,760 --> 00:13:28,620
+الجينات مش جين واحد 5% تيراتوجين تيراتو يعني مسبب
+
+109
+00:13:28,620 --> 00:13:33,280
+للمشاكل
+
+110
+00:13:33,280 --> 00:13:37,400
+التطورية
+
+111
+00:13:37,930 --> 00:13:46,270
+ماشي، اللي هي مثلًا أشهر قصة تتذكروا بالنسبة لشغل
+
+112
+00:13:46,270 --> 00:13:52,730
+Teratogen دوة اسمها «الثالودامايد» «الثالودامايد»
+
+113
+00:13:52,730 --> 00:14:00,230
+عبارة عن في الخمسينات حتى في أمريكا مبسوطين إن
+
+114
+00:14:00,230 --> 00:14:07,010
+وكالة الدواء والغذاء منعت دخوله من أوروبا لأمريكا
+
+115
+00:14:08,100 --> 00:14:15,420
+فهو عبارة عن دوة مخفف لأعراض الغثيان والاستفراج
+
+116
+00:14:15,420 --> 00:14:21,340
+وخصوصاً الحوامل يعني معروف الحوامل بيجي عندهم
+
+117
+00:14:21,340 --> 00:14:25,540
+غثيان واستفراج وبعضاً في أول الحمل وبعضاً في أوسطه
+
+118
+00:14:25,540 --> 00:14:31,460
+وبعضاً ويلها هاي أسباب كثيرة فالـ Thalidomide دوة
+
+119
+00:14:31,460 --> 00:14:38,620
+أصبح بالذات في أوروبا لقضية غثيان الحوامل دوةكثير
+
+120
+00:14:38,620 --> 00:14:44,480
+الانتشار نتيجة استخدام هذا الدواء هناك نسبة عالية
+
+121
+00:14:44,480 --> 00:14:53,200
+أو نسبة محترمة من وجود ولود أو ولادة أو تخلق أطفال
+
+122
+00:14:53,200 --> 00:14:59,580
+بغير أطرافه، ناشي؟ يعني مافيش إيدين، مافيش رجلين
+
+123
+00:14:59,580 --> 00:15:05,600
+الأربعة، تلاتة، اتنين، يعني التطوراتيعني الـ
+
+124
+00:15:05,600 --> 00:15:10,920
+Congenital Defect كبير جدًا كان
+
+125
+00:15:10,920 --> 00:15:17,780
+هناك بنقصين وباء من قضية ولادة أطفال مشوهين بلا
+
+126
+00:15:17,780 --> 00:15:22,140
+أطراف فثبت بعدين إن هذا هو الـ Thalidomide كان
+
+127
+00:15:22,140 --> 00:15:31,820
+السبب ليش وكيف وكذا كانت
+
+128
+00:15:31,820 --> 00:15:37,440
+تجربة سيئة في العالم ومنعالآن الـ Thalidomide هو
+
+129
+00:15:37,440 --> 00:15:47,420
+دوة حكينا أنه قوى جداً وكويس ضد الغثيان والاستفراغ
+
+130
+00:15:47,420 --> 00:15:53,760
+والعيان وهو مظاهر مزعجة جداً وهو فعال جداً، فالآن
+
+131
+00:15:53,760 --> 00:16:00,950
+في حالات قليلة منمثلًا حالات متقدمة من السلطان
+
+132
+00:16:00,950 --> 00:16:07,370
+وفيها رثيان واستفرار في بعض الحالات الأخرى للأن
+
+133
+00:16:07,370 --> 00:16:14,670
+يُستخدم فالـ Thalidomide هو الـ «تيراتوجين» وإله
+
+134
+00:16:14,670 --> 00:16:19,770
+قصته ويعني أنا أظن أنه حتى يعني في الثقافة العامة
+
+135
+00:16:19,770 --> 00:16:26,720
+عند الناس يعني بالذات أول الحمل الأصلمرة الحامل ما
+
+136
+00:16:26,720 --> 00:16:31,280
+تأخذ أدوية ويحاول الواحد يبعد عن الأدوية إلا إذا
+
+137
+00:16:31,280 --> 00:16:35,300
+فيه ضرورة لهذا الدواء من ناحية ومن ناحية ثانية
+
+138
+00:16:35,300 --> 00:16:45,040
+يكون هذا الدواء مثبت أنه بشكل مفيد يعني
+
+139
+00:16:45,040 --> 00:16:48,740
+من الجوانب اللي يجب تكون معروفة عند الواحد أن
+
+140
+00:16:48,740 --> 00:16:57,140
+الأدوية بالنسبة للحمليُقال عنها A وB وC Class A
+
+141
+00:16:57,140 --> 00:17:06,380
+وClass B وClass C Class A هو دوة ثبت أمنه وثبت
+
+142
+00:17:06,380 --> 00:17:13,140
+فائدته يعني إنه لا يسبب أي تأثير سلبي على الحمل
+
+143
+00:17:13,140 --> 00:17:22,570
+Class C يعني ممنوع وثبت إنه مضر Class Bاللي بالنص
+
+144
+00:17:22,570 --> 00:17:27,070
+يعني اللي يقولها بيقولّه «أه و لا لأ» يعني it
+
+145
+00:17:27,070 --> 00:17:34,630
+wasn't proven teratogenic و dangerous و ممنوع ولا
+
+146
+00:17:34,630 --> 00:17:40,670
+ثبت أنه آمن و كويس هذه بيقولّك أنت كطبيب مع
+
+147
+00:17:40,670 --> 00:17:50,090
+المريضة بتتناقشوا، بتقدروا حسب درجة خطورة و إزعاج
+
+148
+00:17:51,070 --> 00:17:56,170
+التأثير العرض والمرض عليه للمريضة بنعطي الدواء أو
+
+149
+00:17:56,170 --> 00:18:06,090
+بالبطلة فهي النقطة الأساسية إنه أكثر من يعني فيه
+
+150
+00:18:06,090 --> 00:18:17,210
+هناك حوالي 40% عبارة عن تداخل حالات وأوضاع وراثية
+
+151
+00:18:17,210 --> 00:18:24,480
+Single gene أو Teratogenأو أكثر من خلل في نفس
+
+152
+00:18:24,480 --> 00:18:34,620
+الوقت فإحنا اللي بنلاحظ هنا إنه تقريبًا يعني أكثر
+
+153
+00:18:34,620 --> 00:18:43,560
+من النصف، يعني نتكلم على بعض، 35، 20، 55% إبارة عن
+
+154
+00:18:43,560 --> 00:18:53,980
+حالات Genetic، حالات ورافيةبطرق مختلفة وبتكون هناك
+
+155
+00:18:53,980 --> 00:19:02,460
+إشكاليات من الـMultifactorial قضية اللي حكينا عنها
+
+156
+00:19:02,460 --> 00:19:06,860
+مرة جيبنا عرض عنها اللي هي تعويض الـFolic Acid عند
+
+157
+00:19:06,860 --> 00:19:13,920
+الحوامل حيث أنه نقص الـFolic Acid بسبب ما يسمونه
+
+158
+00:19:13,920 --> 00:19:19,760
+الـNeuronal Tube Defect عبارة عن اختلالات فيلتطور
+
+159
+00:19:19,760 --> 00:19:23,840
+الجهاز العصبي بشكل معين ويصير في حالة بنسميها
+
+160
+00:19:23,840 --> 00:19:31,700
+«Spina Bifida» يعني أنه فتحة في الحبل الشوكي بحيث
+
+161
+00:19:31,700 --> 00:19:36,860
+أنه ما بيسكر بالشكل السليم وبالتالي، تطور الأعصاب
+
+162
+00:19:36,860 --> 00:19:44,380
+بيكون بشكل مضروب وممكن يعني إيه درجات، منها الخفيف
+
+163
+00:19:44,380 --> 00:19:49,170
+كثير اللي يلاقي كاد يختلف عنالإنسان الطبيعي وفي
+
+164
+00:19:49,170 --> 00:19:56,530
+حالات أخرى بتكون شديدة كثيرًا يعني شلال نصف الجسم
+
+165
+00:19:56,530 --> 00:20:04,210
+السفلي مثلًا بتكون كاملة يعني الفكرة من المحاضرة
+
+166
+00:20:04,210 --> 00:20:13,010
+اليوم بقول إن أنا أود أتذكر هذا الشريحة
+
+167
+00:20:13,010 --> 00:20:18,640
+وقضية إنهحوالي الخمس هي single gene defect
+
+168
+00:20:18,640 --> 00:20:25,680
+بالأشياء اللي بنشوفها other forms of genetic
+
+169
+00:20:25,680 --> 00:20:30,800
+anomalies زي copy number of certain chromosome
+
+170
+00:20:30,800 --> 00:20:36,360
+variant أو copy number of certain gene variants
+
+171
+00:20:36,780 --> 00:20:41,220
+حوالي 10% على مستوى الـChromosome أنماليز تقريبًا
+
+172
+00:20:41,220 --> 00:20:48,220
+25% والبقية تيراتوجين واضح، External، مش شغل
+
+173
+00:20:48,220 --> 00:20:52,880
+الـGenetic أو يعني الـPure، Non-Genetic Cause
+
+174
+00:20:52,880 --> 00:20:57,460
+حوالي 5% كتيراتوجين بدنا نسميه والبقية هي
+
+175
+00:20:57,460 --> 00:21:00,180
+Interaction between more than one thing ممكن
+
+176
+00:21:00,180 --> 00:21:05,930
+Environmental مع الـGenetic بشكل يعنيالـMore
+
+177
+00:21:05,930 --> 00:21:14,570
+Dilute، الـ «55% التسبب الوراثي قوي وواضح» معاها
+
+178
+00:21:14,570 --> 00:21:22,110
+فمن الأشياء اللي بنشوفها يعني ظواهر أحيانًا يعني
+
+179
+00:21:22,110 --> 00:21:27,990
+كلمة «congenital» وإلى دخل بالـ «development» ماشي
+
+180
+00:21:28,470 --> 00:21:34,450
+بيكون الأشياء اللي تحدث في الـ fetal period الـ
+
+181
+00:21:34,450 --> 00:21:38,630
+embryonic period الـ embryonic بالأول الـ embryo
+
+182
+00:21:38,630 --> 00:21:44,650
+وبعدين الـ fetus بتصير فأحيانًا مثلًا الـ amniotic
+
+183
+00:21:44,650 --> 00:21:49,590
+bands يعني الـ development بتكون بطريقة مش سليمة
+
+184
+00:21:49,590 --> 00:21:54,110
+بحيث أنه شغلي مثلًا الحبل
+
+185
+00:21:59,370 --> 00:22:07,090
+ممكن يعمل مشكلة الـ Ammoniac Band هنا يعني عبارة
+
+186
+00:22:07,090 --> 00:22:15,550
+عن Band ممكن تقطع جزء من الأطراف،
+
+187
+00:22:15,550 --> 00:22:22,370
+تقطع من الـ هنا مثلا، Band واضحة اللي هي ملسقة
+
+188
+00:22:22,370 --> 00:22:28,560
+أصبعين على بعضوفي الجهة الأخرى قصة الـ
+
+189
+00:22:28,560 --> 00:22:37,280
+«development» تبع الـ «thumb»، الإبهام فحتى
+
+190
+00:22:37,280 --> 00:22:43,100
+الـ «fourth digit amputated distally» ماشي وعليها
+
+191
+00:22:43,100 --> 00:22:48,960
+«amniotic membrane» يعني مجزرة فهي أحيانًا يعني
+
+192
+00:22:48,960 --> 00:22:57,590
+دواهر يعني كلمة «amniotic» قصدتلما نقول
+
+193
+00:22:57,590 --> 00:23:02,150
+«congenital» أحيانًا يعني مش بالضرورة يعني أحيانًا
+
+194
+00:23:02,150 --> 00:23:06,270
+نقول «congenital anomaly» لأنها تحدث، بتبين خلال
+
+195
+00:23:06,270 --> 00:23:15,130
+الحمل والقضية هنا إنه ممكن يكون هذه أشياء عبارة عن
+
+196
+00:23:15,130 --> 00:23:23,830
+أشياء بيئية يعني مثلًا يعني أسا مثلًا الذكاء
+
+197
+00:23:24,570 --> 00:23:28,890
+الزيكا، زيكا بايروس، سادة المفروض تكونوا عارفين
+
+198
+00:23:28,890 --> 00:23:34,110
+عنه ممكن يجيكم حتى في الأسئلة و لا كده زيكا عبارة
+
+199
+00:23:34,110 --> 00:23:44,710
+عن مرض فيروسي بينتقل عن طريق فرصة البعوض يعني زي
+
+200
+00:23:44,710 --> 00:23:50,830
+حمض ضنك اللي هي الـ Dingo fever الـ Zika عبارة عن
+
+201
+00:23:50,830 --> 00:23:52,090
+قبل
+
+202
+00:23:53,990 --> 00:23:59,450
+قبل الـ «كورونا» يعني قبلها خمس سنين كان الـ
+
+203
+00:23:59,450 --> 00:24:07,230
+«زيكا» هو اللي عامل يعني رعب في العالم والسبب إنه
+
+204
+00:24:07,230 --> 00:24:12,850
+إذا المرأة الحامل صابها، شو بيصير فيه؟ حد بعرف؟
+
+205
+00:24:12,850 --> 00:24:19,350
+عشان أشوف صحين معاي ولا عندكم إشي؟ شو بعمل الـ
+
+206
+00:24:19,350 --> 00:24:26,670
+«زيكا»؟ألماذة، إيمان، كريم، آيو كريم، كرمل حد
+
+207
+00:24:26,670 --> 00:24:32,890
+بيعرف شو بعمل الذيكا يعني إذا أنتوا بتتابعوا
+
+208
+00:24:32,890 --> 00:24:38,270
+الأيام هذه بالذات من البلاد المضروبة بوباء
+
+209
+00:24:38,270 --> 00:24:42,570
+الكورونا في أمريكا وفيهم عالم مشهور اسمه Antony
+
+210
+00:24:42,570 --> 00:24:43,170
+Fauci
+
+211
+00:24:46,160 --> 00:24:50,920
+يعني هو المستشار للرؤوساء الأمريكان مستشار الصحي
+
+212
+00:24:50,920 --> 00:24:57,400
+للرؤوساء الأمريكان من عهد Reagan يعني بيقول نصحت
+
+213
+00:24:57,400 --> 00:25:02,680
+ست رؤوساء أمريكية أنه اللي غلبوا بس هو الـTrump من
+
+214
+00:25:02,680 --> 00:25:09,720
+أيام الـHIV والـAIDS والـepidemic وكل كده فبالنسبة
+
+215
+00:25:09,720 --> 00:25:13,900
+له كام من المشاكل اللي اتعامل معها هو الذيكا فشو
+
+216
+00:25:13,900 --> 00:25:23,050
+بيعمل الـVirus الذيكا؟إذا حد بيعرف يمكن ما يتابعوش
+
+217
+00:25:23,050 --> 00:25:31,930
+جرايد وكذا بيعمل إنه ضمور الدماغ يعني بيخلّي
+
+218
+00:25:31,930 --> 00:25:37,690
+فبالبرازيل بالذات في منطقة البرازيل أجت عندهم وباء
+
+219
+00:25:37,690 --> 00:25:44,960
+من إن الأطفال بيطلعوا روصهم صغاروعندهم تخلف عقلي
+
+220
+00:25:44,960 --> 00:25:50,400
+وعندهم مشكلة في الذكاء وفي النمو العصبي والعقلي
+
+221
+00:25:50,400 --> 00:25:57,260
+يعني فالـ Zika ثبت إنه عبارة عن فيروس في الأول
+
+222
+00:25:57,260 --> 00:26:05,050
+للحملإذا قرصت الحامل الدنيا حرّه بهالليل والبعوض
+
+223
+00:26:05,050 --> 00:26:11,330
+كثير وقرصت بالفيروس هذا بنتج عنه إن حجم الدماغ
+
+224
+00:26:11,330 --> 00:26:22,690
+بيطلع صغير وبيطلع الطفل مشوّه بطريقة ما فالنقطة
+
+225
+00:26:22,690 --> 00:26:30,730
+اللي بدنا نوصلها إنهالعوامل البيئية سواء من ناحية
+
+226
+00:26:30,730 --> 00:26:36,210
+التغذية سواء من ناحية الالتهابات يعني في الـ
+
+227
+00:26:36,210 --> 00:26:44,390
+«روبيلا» اللي فيه بيسموه مثلا من أسباب حتى
+
+228
+00:26:44,390 --> 00:26:49,610
+الإجهاض المبكر أو وفاة الجنين وكذا بيسموه
+
+229
+00:26:49,610 --> 00:26:57,090
+«التورتش» اللي هي «Trichomonas Rubella»يعني مجموعة
+
+230
+00:26:57,090 --> 00:27:03,830
+فيروسات على بكتيريا تُكسب لازموسس اللي هو نوع من
+
+231
+00:27:03,830 --> 00:27:15,410
+الطفيليات حتى فهناك أسباب كثيرة لحدوث مشاكل خلقية
+
+232
+00:27:15,410 --> 00:27:21,030
+بين قلصين أحنا بنترجمهايعني حدوثها خلال التخلق
+
+233
+00:27:21,030 --> 00:27:27,830
+اللي هي congenital بس يعني حقيقة الأسباب متعددة
+
+234
+00:27:27,830 --> 00:27:33,350
+والأسباب أحيانًا ورافية بنسبة كبيرة بس كمان بيئية
+
+235
+00:27:33,350 --> 00:27:38,330
+بنسبة مقاربة تقريبًا بس أقل شوية يعني هنا البيئية
+
+236
+00:27:38,330 --> 00:27:46,360
+تقريبًا تيجي 45 الورافية بشكل أو الجينية بشكل55%
+
+237
+00:27:46,360 --> 00:27:54,700
+على أقل على كلام دراسة معينة أحيانًا
+
+238
+00:27:54,700 --> 00:28:02,500
+يعني أنا الحالات هذه ما قريت قديش مسبب حدوثها
+
+239
+00:28:02,500 --> 00:28:12,800
+فبنتبه الواحد للأطفال اللي بيجوا وبشوف كام يعني
+
+240
+00:28:12,800 --> 00:28:13,320
+كام
+
+241
+00:28:15,860 --> 00:28:22,900
+ووجود مجموعة الظواهر
+
+242
+00:28:22,900 --> 00:28:27,480
+أو الأعراض أو الـ «symptoms» و«signs» الأعراض
+
+243
+00:28:27,480 --> 00:28:34,280
+والعلامات اللي بنشوفها يعني أحيانًا بنتبه الواحد
+
+244
+00:28:34,280 --> 00:28:38,480
+إنه تقريبًا أنا ممكن كان شُفت حالة زي هيك أو إنسان
+
+245
+00:28:38,480 --> 00:28:45,620
+شكله زي هيكهنا أسئلة اسمها «ربينشتاين تايبي
+
+246
+00:28:45,620 --> 00:28:54,380
+سندروم» إبارة عن تخلف عقلي أو تخلف مش عقلي فقط
+
+247
+00:28:54,380 --> 00:29:06,340
+وإنما تخلف أو تأخر، تطوري فبتلاقي الأطفال المصابين
+
+248
+00:29:06,340 --> 00:29:14,490
+إلهم هنا وجهبشكل معين يعني Distinctive facial
+
+249
+00:29:14,490 --> 00:29:19,750
+appearance الأصابع والأبافر أو الأيدين يعني هيك
+
+250
+00:29:19,750 --> 00:29:28,490
+عريضات بشكل أكبر من المتوقع يعني Large toes ومشاكل
+
+251
+00:29:28,490 --> 00:29:32,450
+في القلب فالجميل
+
+252
+00:29:32,450 --> 00:29:37,970
+يعني لما نكون عند واحد عائلة وليش سموها بهذا الإسم
+
+253
+00:29:37,970 --> 00:29:42,450
+اللي هم هذول اتنيناللي اشتركوا «روفنشتاين» وType B
+
+254
+00:29:42,450 --> 00:29:47,330
+Syndrome أنا بتوقع على الأقل الـMajor Things اللي
+
+255
+00:29:47,330 --> 00:29:53,750
+أنتوا بتشوفوها وجابيلكم إياها مش غلط الواحد يقرأ
+
+256
+00:29:53,750 --> 00:29:58,330
+عنها وعلى الأقل بتعطي الواحد هيك حصيلة جيدة من
+
+257
+00:29:58,330 --> 00:30:03,530
+أسماء أنواع المشاكل الـ
+
+258
+00:30:06,740 --> 00:30:13,200
+لأ، اللي كان دور العالمين هذولة في .. يعني ليش
+
+259
+00:30:13,200 --> 00:30:17,820
+حطوا الإسم باسمهم جزء من الموضوع يمكن بيكونوا هم
+
+260
+00:30:17,820 --> 00:30:24,500
+أول ناس لقوا عائلة أو درسوها أو بيحاولوا يدرسوا شو
+
+261
+00:30:24,500 --> 00:30:36,120
+المسبب فالـ .. هنا القيلة إن الموضوععبارة عن خسارة
+
+262
+00:30:36,120 --> 00:30:45,540
+وظيفة جينات أثنان بشكل قريبين
+
+263
+00:30:45,540 --> 00:30:52,360
+جداً على بعض عبارة عن الـ Closely Related
+
+264
+00:30:52,360 --> 00:30:59,180
+Transcriptional Coactivators Transcriptionيعني
+
+265
+00:30:59,180 --> 00:31:06,280
+لموضوع عملية تحويل الـ «DNA» إلى الـ «RNA» يعني
+
+266
+00:31:06,280 --> 00:31:13,720
+نقل وقراءة خط الـ «DNA» واستخلاص المادة الوراثية
+
+267
+00:31:13,720 --> 00:31:18,720
+منه لتحويلها إلى الـ «RNA» حتى نطلع منها الـ
+
+268
+00:31:18,720 --> 00:31:26,920
+«بروتين» ففيه «coactive headers» معينةCBP يعني
+
+269
+00:31:26,920 --> 00:31:37,280
+عصاي لفوق وبعدين B لتحت عصاي لتحت أو EP300 فهذه
+
+270
+00:31:37,280 --> 00:31:40,920
+الطريقة
+
+271
+00:31:40,920 --> 00:31:45,320
+وهذه الظواهر
+
+272
+00:31:45,320 --> 00:31:51,640
+ما هي علاقتها بشكل مباشر فيهذا الـ «جين» بهذه
+
+273
+00:31:51,640 --> 00:31:57,560
+الطريقة بتكون لسه من الأسرار اللي ربنا بيمتلكها
+
+274
+00:31:57,560 --> 00:32:03,460
+وكل ما يكتشف الواحد أشياء بيكتشف اللي لسه مش عارف
+
+275
+00:32:03,460 --> 00:32:10,860
+أحيانًا المظهر اللي احنا بنشوفه هو نتيجة خلل في
+
+276
+00:32:10,860 --> 00:32:18,210
+جانب معين وزي ما انتم لاحظين قضية أنهالوجه،
+
+277
+00:32:18,210 --> 00:32:23,370
+الأطراف، القلب يعني مأثر على كذا محل في جسم
+
+278
+00:32:23,370 --> 00:32:29,090
+الإنسان والنمو مش طبيعي هناك
+
+279
+00:32:29,090 --> 00:32:38,970
+يعني بواهر يعني النقطة
+
+280
+00:32:38,970 --> 00:32:44,870
+اللي بحكوها بالنسبة للي حطيناها قبل شويةكان قدرنا
+
+281
+00:32:44,870 --> 00:32:51,370
+نصل إلى إن هوين الجين اللي عامل الاختلال
+
+282
+00:32:51,370 --> 00:32:58,110
+اللي احنا شفناه من المظاهر اللي شفتوها أو المفروض
+
+283
+00:32:58,110 --> 00:33:04,350
+يعني هي تعتبر جزء من الـ Anatomy اللي هي قضية الـ
+
+284
+00:33:04,350 --> 00:33:08,790
+Embryology الـ Embryology كيف الإنسان بتخلق وكيف
+
+285
+00:33:08,790 --> 00:33:12,990
+الخلايا بتهاجر وكيف بتنمو بهذا الشكل
+
+286
+00:33:16,740 --> 00:33:24,000
+الـ… الـ… الـEmbryogenesis بالأخير، هجرت الخلايا
+
+287
+00:33:24,000 --> 00:33:28,940
+زي حتى خلايا المناعة أو خلايا الدم تبدأ في كيس
+
+288
+00:33:28,940 --> 00:33:34,980
+المحة اللي هي في الـEgg Yolk تنتقل للـLiver
+
+289
+00:33:34,980 --> 00:33:39,340
+والـSpleen للكبد والتحال، وبعدين تنتقل في الـBone
+
+290
+00:33:39,340 --> 00:33:43,930
+Marrow بس يولد الإنسان بتبين بالـBone Marrowبالـ
+
+291
+00:33:43,930 --> 00:33:48,110
+Bomber وبشكل أساسي هذه الهجرة أو هذا التنقل أو هذا
+
+292
+00:33:48,110 --> 00:33:58,730
+التطور عبارة عن ظواهر محكومة بدوافع، بمؤشرات أو
+
+293
+00:33:58,730 --> 00:34:02,390
+بـ، يعني فيه إشي بيقول الخلية أترك هنا و أروح
+
+294
+00:34:02,390 --> 00:34:10,550
+هناك، فيه إشي بيقول الخلية أعمل هيك وسوي هيكففي
+
+295
+00:34:10,550 --> 00:34:16,190
+حالة يمكن حتى إذا دخل باللي قبل شوية تسمينها الـ
+
+296
+00:34:16,190 --> 00:34:23,130
+Robin Sequence من المشاكل أحيانًا بعض الناس الأصل
+
+297
+00:34:23,130 --> 00:34:27,970
+في الإنسان الـNormal يعني تخيلنا هذه الصورة إنه
+
+298
+00:34:27,970 --> 00:34:35,070
+تكون الذقن السفلي أو الفك السفلي هجم معين بيكون
+
+299
+00:34:35,070 --> 00:34:37,410
+يعني
+
+300
+00:34:38,140 --> 00:34:45,640
+متتكوّن بشكل طبيعي بحيث أنه يعطي مجال للسام ينمو
+
+301
+00:34:45,640 --> 00:34:52,660
+بشكل طبيعي أحياناً حتى بعض الناس بيكون الذقن تبعه
+
+302
+00:34:52,660 --> 00:34:58,460
+يمكن يتجانب منه عائلي يعني وراثة بتشوف شكل الوجه
+
+303
+00:34:58,460 --> 00:35:03,320
+كيف في تقارب بين الأباء و الأمات وبتلاقي بعض الناس
+
+304
+00:35:03,320 --> 00:35:10,620
+الذقن جاي لورا وبنسميهالـ Receding أو Hypoplasia
+
+305
+00:35:10,620 --> 00:35:15,240
+of the mandible وPosterior displacement of the
+
+306
+00:35:15,240 --> 00:35:19,720
+tongue يعني اللي هي زي ما هم شايفين هنا يعني هي
+
+307
+00:35:19,720 --> 00:35:28,200
+أحيانًا حتى إنسان يولد بشكل طبيعي يعني قضيني إذا
+
+308
+00:35:28,200 --> 00:35:32,760
+حد بتشوف يعني البارح بتطلع انتخابات الأمريكية
+
+309
+00:35:32,760 --> 00:35:40,160
+الرئيس الـمدرسة الشيوخ «السناترز» الأمريكي «جون
+
+310
+00:35:40,160 --> 00:35:45,920
+ماتشيل» يظن اسمه واحد بيشوف الفك السفلي راجع لورا
+
+311
+00:35:45,920 --> 00:35:55,100
+كتير والـ «طاند» بيكون ألسان مش ماخد مكانه السليم
+
+312
+00:35:55,100 --> 00:36:01,020
+وبالتالي هذا ممكن يسبب شخير ممكن يسببتضيق في
+
+313
+00:36:01,020 --> 00:36:08,980
+المجال التنفسي وإشكالات ممكن يعمل مشاكل فجزء من
+
+314
+00:36:08,980 --> 00:36:12,840
+المشاكل طبعاً فيه اللي بيسموها الـ «لثة» والـ
+
+315
+00:36:12,840 --> 00:36:18,820
+«شفة» ويعني عبارة عن تطور الـ «Embryogenesis» في
+
+316
+00:36:18,820 --> 00:36:24,200
+هذه المنطقة في الفم والأعلى الشفة العليا بيصير
+
+317
+00:36:24,200 --> 00:36:26,200
+«Clift Lip» و«Clift Palate»
+
+318
+00:36:31,470 --> 00:36:37,930
+العربية ويكون هنا فيه مشكلة فالـ Cliff-tip وبلد
+
+319
+00:36:37,930 --> 00:36:44,270
+الإنسان الطبيعي بيكون هكذا أنا شكله طبعاً تحت
+
+320
+00:36:44,270 --> 00:36:52,110
+بينهم هدولة في الددار الخلفي للحلق بتلاقي tonsils
+
+321
+00:36:52,110 --> 00:36:58,550
+وبتلاقي لسان الأصل يكون بشكل معين عندهم هذه
+
+322
+00:36:58,550 --> 00:37:05,320
+المشكلة أحياناًبنلاقي مش هيك شكل مدبّب لفتحة الحلق
+
+323
+00:37:05,320 --> 00:37:17,700
+بتلاقيها مش V على شكل U فتحة الحلق وبالتالي، هذه
+
+324
+00:37:17,700 --> 00:37:25,920
+ممكن تكون من المشاكل التطورات هذه الخلقية تبدأ
+
+325
+00:37:26,650 --> 00:37:31,570
+يعني ممكن واحد يلاحظها من الأسبوع الـ11، السابع
+
+326
+00:37:31,570 --> 00:37:36,370
+عشر من الحمل للأسبوع العشرين للأسبوع التسعة وعشرين
+
+327
+00:37:36,370 --> 00:37:43,710
+كيف الإنسان بيتطور والخلايا بتهاجر وبتكبر وبتصير
+
+328
+00:37:43,710 --> 00:37:48,830
+الـDevelopment تبعته يعني لو أحد شاف عيلة عندها
+
+329
+00:37:48,830 --> 00:37:53,760
+هذه الظاهرةأو بعض الذات أحلى شيء وأحسن شيء يكون
+
+330
+00:37:53,760 --> 00:37:57,760
+مجموعة مصابين عندهم المرض ومجموعة مش مصابين في نفس
+
+331
+00:37:57,760 --> 00:38:03,200
+العائلة في هذه الحالة ممكن تروح الواحد يدور على
+
+332
+00:38:03,200 --> 00:38:10,340
+المشاكل أو وين المشكلة فيها في
+
+333
+00:38:10,340 --> 00:38:20,010
+موضوع مهم كثيريعني إيه دخل بالدين وبالعقيدة
+
+334
+00:38:20,010 --> 00:38:30,750
+وبالكيف بيميز الواحد حاله عن الآخرين؟ قضية يعني
+
+335
+00:38:30,750 --> 00:38:35,670
+إحنا مقتنعين إن الله سبحانه وتعالى خلق آدم وحواء
+
+336
+00:38:35,670 --> 00:38:41,890
+من خلق مباشر وبغير يعني
+
+337
+00:38:44,160 --> 00:38:51,780
+بشكل مباشر، يعني ما أطورنا من بين قوسين قرد أو أصل
+
+338
+00:38:51,780 --> 00:38:59,720
+أشي مشابه للقرد ونشقّنا عنهم وكدا، الآن الإيمان
+
+339
+00:38:59,720 --> 00:39:07,780
+بهذا الجانب، صحيح، والإيمان دائماً بقول بالـ
+
+340
+00:39:07,780 --> 00:39:11,760
+Carbon-Cosموعة بقول الإيمان بالغيب، يعني الإيمان
+
+341
+00:39:11,760 --> 00:39:17,770
+إنك أنتهذا جانب ربنا حكى عنه «ما أشهدتهم خلق
+
+342
+00:39:17,770 --> 00:39:21,770
+السماوات والأرض، ولا خلق أنفسهم، وما كنتم اتخذ
+
+343
+00:39:21,770 --> 00:39:26,830
+المظلين عضوًا» يعني ربنا قرر، والقرآن ما أظن أن
+
+344
+00:39:26,830 --> 00:39:33,610
+حدا أثبت أنه فيه جانب مخطئ أو خاطئ فربنا حكى «أنا
+
+345
+00:39:33,610 --> 00:39:38,330
+ما فرجيتكم كيف خلقتكم، كيف بدأتكم، كيف كذا» وهذا
+
+346
+00:39:38,330 --> 00:39:42,150
+يعني جانب
+
+347
+00:39:43,270 --> 00:39:54,390
+أنا مؤمن به ولكن هذا الإيمان لا يتنافى مع طلب الله
+
+348
+00:39:54,390 --> 00:40:04,010
+أيضًا إن النظر وتفكير العقل وتفكير
+
+349
+00:40:04,010 --> 00:40:10,870
+أطلاق نشاط الدماغ ربنا كرّم آدم وخلّى الملائكة
+
+350
+00:40:10,870 --> 00:40:20,740
+تسجد لهرفض بعضها أو رفضهم واستغرابهم لقضية إنه
+
+351
+00:40:20,740 --> 00:40:27,660
+عندنا عقل شغلناه يعني لما
+
+352
+00:40:27,660 --> 00:40:32,860
+ربنا طلب من الملائك تسمية أسماء شيء معين يعني زي
+
+353
+00:40:32,860 --> 00:40:39,140
+أعطاهم مسألة أو أعمال
+
+354
+00:40:39,140 --> 00:40:41,300
+العقل والذهن والتفكير
+
+355
+00:40:43,830 --> 00:40:51,930
+فهذا هو ما يميز الإنسان هو مناطق تكليف الإنسان فإن
+
+356
+00:40:51,930 --> 00:40:59,270
+الواحد ينظر كيف ربنا بيخلق الأشياء أحيانًا
+
+357
+00:40:59,270 --> 00:41:05,070
+اللادينيين رفضوا بين قوسين خصوصًا في المجتمع
+
+358
+00:41:05,070 --> 00:41:10,490
+الغربي الكنيسة لأن الكنيسة أجرمت
+
+359
+00:41:12,660 --> 00:41:19,420
+كانت تحاول تحدد من قدرة العالم على الدراسة وعلى
+
+360
+00:41:19,420 --> 00:41:26,080
+التفكير وعلى الاستنتاج أنا أقول التشابهات اللي
+
+361
+00:41:26,080 --> 00:41:33,120
+دفعت بعض العلماء إلى القلب
+
+362
+00:41:33,120 --> 00:41:37,940
+أو المنادة بالتطور والـEvolution
+
+363
+00:41:39,830 --> 00:41:46,930
+إن الكائنات الحية من بعض، هذا كلام صحيح وفي
+
+364
+00:41:46,930 --> 00:41:50,050
+تشابهات
+
+365
+00:41:50,050 --> 00:41:57,670
+معينة بين الكائنات في طريقة بنائها، طريقة عملها
+
+366
+00:41:57,670 --> 00:42:04,370
+أنا أقول، يعني، بدي أفهمها لوحدة على إنها مؤشرة
+
+367
+00:42:04,370 --> 00:42:12,270
+على إن الخالق واحد، المنشئ واحدوهذه أكفأ وأحسن
+
+368
+00:42:12,270 --> 00:42:15,470
+ويعني
+
+369
+00:42:15,470 --> 00:42:19,650
+لما ربنا قد كتبنا في الزبور من بعد الذكر أن الأرض
+
+370
+00:42:19,650 --> 00:42:25,230
+يرثها عبادي الصالحون الصالحون يعني هنا يمكن يكون
+
+371
+00:42:25,230 --> 00:42:29,470
+على مستوى إذا أردنا البشر من الصالحين من البشر
+
+372
+00:42:29,470 --> 00:42:38,540
+ولكن على مدى كما نرى في الأحافير وفي الـالسجل
+
+373
+00:42:38,540 --> 00:42:46,920
+القديم من تكون الخلق على الأرض بنلاقي إنه يعني
+
+374
+00:42:46,920 --> 00:42:54,100
+هناك تطور بشكل معين يعني فمن الأشياء اللي أجدها
+
+375
+00:42:54,100 --> 00:42:58,900
+مثيرة وبحاول أقرا عنها وأدرسها راح نيجي على جانب
+
+376
+00:42:58,900 --> 00:43:06,630
+آخر فيها تشابه فيتطور الإنسان بالذات في مرحلة
+
+377
+00:43:06,630 --> 00:43:11,330
+الجنين
+
+378
+00:43:11,330 --> 00:43:16,270
+وبعد ذلك الولادة وبعد ذلك النمو والبلوغ ثم بعد ذلك
+
+379
+00:43:16,270 --> 00:43:26,890
+الهرم والوفاة فالإنسان هنا بيحاول أن يظهروا
+
+380
+00:43:26,890 --> 00:43:34,870
+مدى تشابه أو اختلافالتركيب العظمي، يعني هذا جانب
+
+381
+00:43:34,870 --> 00:43:43,810
+مهم في علم الأحافير وعلم تحديد الأجناس وتحديد ما
+
+382
+00:43:43,810 --> 00:43:48,790
+هو الكائن اللي هذه العظمة منه، يعني دراسة الإضاءة،
+
+383
+00:43:48,790 --> 00:43:56,160
+فمن دراسات الإضاءة المهمةإنه أرقى كائن حي ولقد
+
+384
+00:43:56,160 --> 00:44:00,800
+خلقنا الإنسان في أحسن تقويم اللي هو الإنسان يعني
+
+385
+00:44:00,800 --> 00:44:08,280
+حقيقة إن الإنسان يقف منتصب على رجلين ويدايه هرتان
+
+386
+00:44:08,280 --> 00:44:14,500
+يحركما كما يشاء في إن الواحد بكتب، برسم، بشتغل
+
+387
+00:44:14,500 --> 00:44:20,720
+بيده، بآلة، كذا كذاهذه قضية يعني سبحان الله معجزة
+
+388
+00:44:20,720 --> 00:44:28,520
+ورائعة ودرجة الخلق
+
+389
+00:44:28,520 --> 00:44:34,260
+المتقن المحكم كبيرة جداً فحتى يقف الإنسان بهذا
+
+390
+00:44:34,260 --> 00:44:43,120
+الشكل يجب أن تكون عظامه بشكل محدد فإن عظمة العاضض
+
+391
+00:44:43,120 --> 00:44:49,690
+أو الـ Humerusوبعدين الـ Forearm اللي هين أو يعني
+
+392
+00:44:49,690 --> 00:44:56,590
+هيسموها Upper Arm من منطقة العضد هذه المنطقة
+
+393
+00:44:56,590 --> 00:45:04,710
+وبعدين منطقة اليد أو الـ Forearm اللي هي
+
+394
+00:45:04,710 --> 00:45:11,130
+الـHumerus وبعد الـHumerus أزف الألنى والراديوس
+
+395
+00:45:11,130 --> 00:45:18,190
+وبعدين منطقة الرسماللي هي منطقة الـ Carpels وبعدين
+
+396
+00:45:18,190 --> 00:45:23,330
+الـ Metacarpels والـ Phalanges السلامة باللغة
+
+397
+00:45:23,330 --> 00:45:28,790
+العربية حقيقةً يعني تطور إضام الإنسان بهذا الشكل
+
+398
+00:45:28,790 --> 00:45:37,690
+ماشي يعني تطور الإنسان بهذا الشكل يعني صراحة معجز
+
+399
+00:45:37,690 --> 00:45:41,030
+ومميز
+
+400
+00:45:42,170 --> 00:45:49,910
+مؤدى للهدف إنه الإنسان بأصابعه وبيديه يستطيع أن
+
+401
+00:45:49,910 --> 00:45:55,370
+يعمل أشياء كثيرة جداً جداً الألات والاستخدامات
+
+402
+00:45:55,370 --> 00:46:01,870
+وحتى قضية الإحساس يعني سبحان الله القرآن الكريم
+
+403
+00:46:01,870 --> 00:46:09,340
+معجز يا شباب ويعني لما ربنا يقولّكهيحسب الإنسان
+
+404
+00:46:09,340 --> 00:46:13,820
+ولا نجمع عظامة بلا قادرين على أن نصوية بنانا
+
+405
+00:46:13,820 --> 00:46:22,040
+البصمة هذه البصمة الحقيقية للأنامل الإنسان مميزة
+
+406
+00:46:22,040 --> 00:46:30,520
+لكل واحد لا يوجد أثنين عندهم نفس البصمة وعشان هيك
+
+407
+00:46:30,520 --> 00:46:37,210
+في الطب الشرعيالتحقيقات الجناية وغيرها بيعتمدوا
+
+408
+00:46:37,210 --> 00:46:41,830
+على البصمة اللي تتركها نامل الإنسان فهذه كلها
+
+409
+00:46:41,830 --> 00:46:49,190
+معجزات اللي واحد بيشوفها فلو جينا أخدنا طائرين أو
+
+410
+00:46:49,190 --> 00:46:57,590
+حيوانات تطير مثلًا مثلًا هنا حمامة بتطير أو Bird
+
+411
+00:46:57,590 --> 00:47:06,110
+وبين خفاش الخفاش طبعًا حيوان ثديوهو تطورياً يعني
+
+412
+00:47:06,110 --> 00:47:12,690
+من التدييات التدييات الـ … يعني مش التدييات العليا
+
+413
+00:47:12,690 --> 00:47:19,970
+زي القردة إنما من التدييات السفلة وبكون بسبيلاً
+
+414
+00:47:19,970 --> 00:47:29,670
+يعني بس هو تدي يعني يحمل ويولد ويغطيه شعر الطير
+
+415
+00:47:29,670 --> 00:47:37,760
+تضع البيض ويغطيها ريشيعني بيكون بهذا الشكل ولكن
+
+416
+00:47:37,760 --> 00:47:44,380
+سبحان الله لو جينا نرى التطور العظمي في الأطراف
+
+417
+00:47:44,380 --> 00:47:52,800
+العلوية بنلاقي أن الطير، مجموعة الإضامة إذا الواحد
+
+418
+00:47:52,800 --> 00:48:00,280
+مسك جراح دجاجي وبقزص بالعظم تبعها، بشوف كيف الـ
+
+419
+00:48:02,280 --> 00:48:09,400
+الترتيب العظام الموجود فيها فنرى أن الأزرق يشبه
+
+420
+00:48:09,400 --> 00:48:14,200
+الـ Humerus التنتين اللي هي زي القلنة والـ Tibia
+
+421
+00:48:14,200 --> 00:48:21,180
+تبعاتنا القلنة والـ Radius تبعاتنا بعدين هناك
+
+422
+00:48:21,180 --> 00:48:25,880
+مجموعة من العظام تشبه عظام الرصب وبعدين مجموعة
+
+423
+00:48:25,880 --> 00:48:34,180
+تشبه الأصابع فهي يعني حتى في الطيرتجد أنها ترتيب
+
+424
+00:48:34,180 --> 00:48:40,060
+مشابه أو قريب بس مختلف تمامًا ومربوط معه أشياء
+
+425
+00:48:40,060 --> 00:48:44,520
+بتؤدي وظيفة مختلفة تمامًا على عكس مثلًا الخفاش
+
+426
+00:48:44,520 --> 00:48:49,700
+الخفاش هنا كترتيب
+
+427
+00:48:49,700 --> 00:49:00,180
+عظمي هميته لقضية الطيران أيضًا مثل الطير ولكنبتكون
+
+428
+00:49:00,180 --> 00:49:07,300
+يعني أقرب جداً للعظام ترتيب العظام عند الإنسان
+
+429
+00:49:07,300 --> 00:49:13,440
+فبرضه الـ Humerus قالنا هو الـ Radius وبعدين الرسب
+
+430
+00:49:13,440 --> 00:49:20,280
+تبعه وبعدين الأصابع وعنده هذه الخمس أصابع وحتى عدد
+
+431
+00:49:20,280 --> 00:49:25,860
+السلامة الـ Phalanges قريبة من عدد الـ Phalanges
+
+432
+00:49:25,860 --> 00:49:36,040
+عند الإنسانيعني هذه بالنسبة بالذات للمادة الورافية
+
+433
+00:49:36,040 --> 00:49:44,560
+وتحكم بتطور هذا الموضوع وواحد التفكير ليش ربنا
+
+434
+00:49:44,560 --> 00:49:49,920
+خلقها بهذه الطريقة طبعاً الأجانب أو كثير من الناس
+
+435
+00:49:49,920 --> 00:49:56,260
+كرهة للكنيسة أو تدخلها في العلم بشكل غير سليميعني
+
+436
+00:49:56,260 --> 00:50:04,400
+إحنا الواحد كمسلم ومؤمن يرى التطور بهذا الشكل يجب
+
+437
+00:50:04,400 --> 00:50:09,340
+أن يستفيد منه، يجب أن ينتبه إليه قُل سيروا في
+
+438
+00:50:09,340 --> 00:50:12,760
+الأرض فانظروا كيف خلق الله السماوات والأرض يعني
+
+439
+00:50:12,760 --> 00:50:18,760
+هيك، طلع، ربنا بيقولك شغّل مخك فوجود هذه ظاهرة
+
+440
+00:50:18,760 --> 00:50:26,700
+جميع، يعني التنبه لها المفروضتدفع بالإنسان أن يصبح
+
+441
+00:50:26,700 --> 00:50:33,360
+مؤمن، أنا من رأيه بهذا الشكل بس هم الـ… يعني الـ…
+
+442
+00:50:33,360 --> 00:50:36,820
+أحيانًا كثير من الغربيين أو غير الغربليين يعني
+
+443
+00:50:36,820 --> 00:50:47,780
+يحاولوا من خلال هذه الظواهر ربطها بشكل يعني إن هذا
+
+444
+00:50:47,780 --> 00:50:55,300
+الكائن من ذاك الكائن الآخر وهي يعني أنا بعتبرهم
+
+445
+00:50:55,300 --> 00:51:02,680
+يتوقفوا عن محاولة شرح من الذي قام بذلك، كيف قام
+
+446
+00:51:02,680 --> 00:51:08,240
+بذلك لأن هذه أمور مجهولة بالنسبة للمغيب، وابد أن
+
+447
+00:51:08,240 --> 00:51:17,560
+نؤمن بها بالغيب ففي كثير من ما نراه من
+
+448
+00:51:17,560 --> 00:51:24,270
+خلق الإنسان بشكل معين نجده في الطبيعة وأحيانًايعني
+
+449
+00:51:24,270 --> 00:51:31,710
+هذه استجابة لضغوطات معينة أو ليه؟ يعني لأنها بتعطي
+
+450
+00:51:31,710 --> 00:51:36,510
+فائدة للكائن اللي هيجدد من ناحية يعني ليش الزرافة
+
+451
+00:51:36,510 --> 00:51:41,270
+رقبتها طويلة؟ أنا بقولك لأنه كائنات على مدى يعني
+
+452
+00:51:41,270 --> 00:51:45,690
+بالحفير اللي بنراها لما تكون الرقبة طويلة كثير
+
+453
+00:51:45,690 --> 00:51:50,010
+بتقدر توكل أكل ماحدش يصلوا ليه من الكائنات اللي
+
+454
+00:51:50,010 --> 00:51:57,410
+بترعى بتكون على مستوى أصغر أو أقل وكدهفتجد إنه فيه
+
+455
+00:51:57,410 --> 00:52:03,450
+دافع معين للتطور بشكل معين يعني أنا أظن إن التطور
+
+456
+00:52:03,450 --> 00:52:10,870
+والانتخاب الطبيعي وغيرها من الظواهر هي أدوات يقوم
+
+457
+00:52:10,870 --> 00:52:19,410
+الله سبحانه وتعالى باستخدامها للتغيير وإن كان كل
+
+458
+00:52:19,410 --> 00:52:27,610
+شيء بقدر من الله سبحانه وتعالىهناك حالة اللي هو
+
+459
+00:52:27,610 --> 00:52:34,390
+سموها الـ Proteus Syndrome يعني الغريب، يعني هذه
+
+460
+00:52:34,390 --> 00:52:41,010
+حالة وقرافية دلوقت بقرا عن تفاصيلها هي
+
+461
+00:52:41,010 --> 00:52:49,250
+Developmental، يعني قضية التطور هناك اختلالات في
+
+462
+00:52:49,250 --> 00:52:58,140
+معدلات التطورالعضاء في جسم الإنسان يعني زي ما هنا
+
+463
+00:52:58,140 --> 00:53:05,020
+تعطونا مثال عليه طفل عندما يولد وولد بشكل طبيعي
+
+464
+00:53:05,020 --> 00:53:11,640
+وأحجام عضاءه متناسقة ولكن بعد السنة الأولى بدر ما
+
+465
+00:53:11,640 --> 00:53:19,060
+يعني يولد بشكل متناسق متساوي في كل الأعضاء عبارة
+
+466
+00:53:19,060 --> 00:53:28,560
+عن أنهمجموعة مثلًا الرجلين صارت أصابع رجليه بتكبر
+
+467
+00:53:28,560 --> 00:53:37,020
+بشكل غير متناسب جزء من وجهه نمى وجزء لم ينمو جزء
+
+468
+00:53:37,020 --> 00:53:42,800
+من جسمه نمى وجزء آخر لم ينمو هذا يسمى الـ Proteus
+
+469
+00:53:42,800 --> 00:53:54,060
+Syndrome والآن يعني لقوابرضه Activator معين
+
+470
+00:53:54,060 --> 00:54:02,040
+Transcriptional Activator في موقع آخر فالفكرة يعني
+
+471
+00:54:02,040 --> 00:54:09,320
+هنا اللي بديوا ياخدوها إنه ليش تحدث إنه في مجموعة
+
+472
+00:54:09,320 --> 00:54:16,340
+خلايا نمت بشكل بالـ Brotius Syndrome هذا يعني
+
+473
+00:54:16,340 --> 00:54:25,820
+نمت بشكل أكبر من غيرهابدأت تتذكر إن الإنسان يبدأ
+
+474
+00:54:25,820 --> 00:54:31,300
+من fertilized egg من خلية بويضة ملقحة طبعاً
+
+475
+00:54:31,300 --> 00:54:35,140
+البويضة قبل التلقيح بتكون قريبة من هذا الشكل بتكون
+
+476
+00:54:35,140 --> 00:54:38,940
+فيه two polar bodies طبعاً هذه صور في الغالب
+
+477
+00:54:38,940 --> 00:54:44,560
+أخدوها من الـ In-vitro fertilization هذه القضية من
+
+478
+00:54:44,560 --> 00:54:49,830
+السبعينات والثمانينات بدأتالتلقيح الصناعي والتلقيح
+
+479
+00:54:49,830 --> 00:54:55,650
+خالج الجسم للإناث أو النساء اللي عندهم مشاكل في
+
+480
+00:54:55,650 --> 00:55:00,370
+الـ Fallopian Tubes يعني هما عندهم كل شيء آخر
+
+481
+00:55:00,370 --> 00:55:07,370
+طبيعي المبيض طبيعي، الرحم طبيعي ولكن طرف الرحم عند
+
+482
+00:55:07,370 --> 00:55:16,350
+المبيض فيه تسكير بالطريق وإغلاق فكانت الحل أنهلما
+
+483
+00:55:16,350 --> 00:55:23,210
+تصير عملية التبويض عند الأنثى هذه تأخذ البوايضة
+
+484
+00:55:23,210 --> 00:55:28,010
+لأن الـ IVF بيحفظوا إنتاج البوايضات حتى يكون عندنا
+
+485
+00:55:28,010 --> 00:55:33,310
+عدد كبير من البوايضات حتى يكون فيه احتمالية حمل
+
+486
+00:55:33,310 --> 00:55:40,370
+كبيرة يعني الأصل بعد ما يعملوا عملية التلقيح
+
+487
+00:55:40,370 --> 00:55:44,990
+ويتكون الأمور سليمة
+
+488
+00:55:45,370 --> 00:55:49,470
+في عملية الارجاع للرحم لازم يعني ثلاث eggs
+
+489
+00:55:49,470 --> 00:55:54,290
+fertilized ليرجعوا علشان يكون فيه احتمالية أن يكون
+
+490
+00:55:54,290 --> 00:55:59,010
+فيه حمل مظبوط فاللي بدأوا يتذكروا أنه من الأشياء
+
+491
+00:55:59,010 --> 00:56:05,650
+اللي تم دراستها قضية أنه الخلية هذه تنقسم إلى
+
+492
+00:56:05,650 --> 00:56:10,370
+خليتين بعد التلقية والخليتين يصيروا أربعة بالـC
+
+493
+00:56:10,370 --> 00:56:14,090
+وبعدين هدول الأربعة بتتحول لثمانية وبعدين ستاشر
+
+494
+00:56:15,270 --> 00:56:22,350
+يومين أو كل يوم يعني الـ Day Zero هنا اللي هي
+
+495
+00:56:22,350 --> 00:56:29,570
+fertilized egg واحدة بس بعد يوم تصبح خليتين بعد
+
+496
+00:56:29,570 --> 00:56:36,030
+يوم ثالث اليوم الثاني بيصيروا أربعة يعني هذه
+
+497
+00:56:36,030 --> 00:56:45,610
+متوالية هندسية أثنين لأُس عدد الأيام ماشيبكون نسبة
+
+498
+00:56:45,610 --> 00:56:55,670
+سرعة في النمو عالية جدًا فيه
+
+499
+00:56:55,670 --> 00:57:04,090
+دائمًا مثل أو كلمة قال أسرع سرطان في نمو نموًا في
+
+500
+00:57:04,090 --> 00:57:12,100
+الجسم هو الجنين الطبيعي تبدأ من خلية واحدةبتتحول
+
+501
+00:57:12,100 --> 00:57:17,340
+لما يولد الإنسان عادةً يعني تلات أو أربعة كيلوز
+
+502
+00:57:17,340 --> 00:57:23,780
+ماشي زائد المشيمة زائد السائل المنيوسي وكذا ويكون
+
+503
+00:57:23,780 --> 00:57:28,140
+له مجموعة كبيرة فبالنسبة
+
+504
+00:57:28,140 --> 00:57:33,660
+في عملية الـ In vitro fertilization بيستطيعوا
+
+505
+00:57:33,660 --> 00:57:39,440
+يراقبوا تطور هذه الخلايا بشكل يومي بشكل دقيق كذا
+
+506
+00:57:39,900 --> 00:57:48,200
+فطبعًا بتكون صورها بهذا الشكل ونتكلم يعني على إنه
+
+507
+00:57:48,200 --> 00:57:54,280
+بعد ذلك تصبح يعني اللي هي مراحل النطفة، العلقة،
+
+508
+00:57:54,280 --> 00:57:58,380
+المضغة، الـ «كذا» يعني اللي ربنا حكي عنها حقيقةً
+
+509
+00:57:58,380 --> 00:58:04,880
+أجمل وصف للتطور اللي أحنا بنشوفه الـPlastocyst هذه
+
+510
+00:58:04,880 --> 00:58:11,180
+هي تصل مرحلة العلقةاللي هي المفروض إنها تعلق في
+
+511
+00:58:11,180 --> 00:58:18,980
+جدار الرحم وبالتالي يعني بعدين تنمو
+
+512
+00:58:18,980 --> 00:58:25,580
+داخله بحيث إنه تكون Machine أو تكون الطبقات اللي
+
+513
+00:58:25,580 --> 00:58:35,810
+هو الكيس الحمل بهذا الشكل، الإنسان سيتكونمن مجموعة
+
+514
+00:58:35,810 --> 00:58:39,550
+الخلايا اللي هنا اللي هي في الطبقة هذه هذه كله
+
+515
+00:58:39,550 --> 00:58:45,230
+بالـ Imperiology المفروض تكونوا ماخدينها وهنا الـ
+
+516
+00:58:45,230 --> 00:58:48,650
+Ammoniac Fluid الـ Ammoniac Cavity بيبدأ يتكون
+
+517
+00:58:48,650 --> 00:58:53,810
+ويتشكل لما هنا تعلق في الرحم إحنا عندنا هنا مرحلة
+
+518
+00:58:53,810 --> 00:59:02,710
+العلقة فالفكرة أنه أحيانًا يعني كل يعني هناك فكرة
+
+519
+00:59:02,710 --> 00:59:11,380
+تامالفكرة الأولى إنه أي خلية حتى تمشي وتسير وتنتقل
+
+520
+00:59:11,380 --> 00:59:19,020
+بهذا الإتجار يجب أن يكون ناتج عن عوامل تخبرها
+
+521
+00:59:19,020 --> 00:59:24,600
+بأنها تتحرك بهذا الإتجار فنجد أن مجموعة Activator
+
+522
+00:59:24,600 --> 00:59:30,480
+Genes، Activator Proteins هما السبب في أن تتحرك
+
+523
+00:59:30,480 --> 00:59:35,890
+الخلية بهذا الإتجارودراسة هذا الموضوع أحيانًا من
+
+524
+00:59:35,890 --> 00:59:42,370
+الدوراسات المهمة اللي بتوضح لنا كيف ربنا خلقنا
+
+525
+00:59:42,370 --> 00:59:47,450
+وكيف الخلايا بتمشي بهذا الشكل فهنا صورة لمراحل
+
+526
+00:59:47,450 --> 00:59:56,030
+بداية التعلق للـBastocyst اللي هي العلقة الفكرة
+
+527
+00:59:56,030 --> 01:00:00,810
+أيضًا إن هناك راح يصبح تخصص لكل خلية
+
+528
+01:00:04,260 --> 01:00:09,000
+فمثلًا، الخلايا الدم فيما فيها خلايا المناعة من
+
+529
+01:00:09,000 --> 01:00:12,340
+أنواع مختلفة الـ Liver and Joints يعني
+
+530
+01:00:12,340 --> 01:00:17,820
+الـLymphocytes اللي هي الخلايا الليمفاوية مش أقل
+
+531
+01:00:17,820 --> 01:00:23,560
+بشكل محدد من ما يقارب الآن 30 نوع خلية كل واحدة
+
+532
+01:00:23,560 --> 01:00:31,200
+لها محددات حتى تسير بهذا الاتجاه فالخلايا الدم
+
+533
+01:00:32,620 --> 01:00:39,200
+الخلية الجذعية للمكوّنة لخلايا الدم تنقسم بشكل
+
+534
+01:00:39,200 --> 01:00:44,700
+ملحوظ لنوعين فيه ما يسمى الـ Myeloid Series والـ
+
+535
+01:00:44,700 --> 01:00:49,920
+Lymphoid Series الـ Myeloid Series مثلًا جزء منها
+
+536
+01:00:49,920 --> 01:00:53,700
+ما سيعطينا خلية الدم الحمراء التي تحمل الـ
+
+537
+01:00:53,700 --> 01:00:56,340
+Hemoglobin اللي بدا أضيفها تعطينا الـ Oxygen
+
+538
+01:00:56,340 --> 01:01:02,170
+وتنقله في الجسم في الجهاز الدوري الـالخلية التي
+
+539
+01:01:02,170 --> 01:01:10,250
+ستصبح خلية دم حمراء يجب أن تتطور بشكل
+
+540
+01:01:10,250 --> 01:01:14,690
+محدد وتبني الـHemoglobin وبعدين تفقد الـNucleus
+
+541
+01:01:14,690 --> 01:01:17,690
+وبعدين كذا الـMegacaryocytes تتحول إلى
+
+542
+01:01:17,690 --> 01:01:25,330
+الـPlatelets الـOthers سواء خلايا الحبابية
+
+543
+01:01:25,330 --> 01:01:27,850
+اللي هي الـNeutrophils والـXenophils والـBasophils
+
+544
+01:01:27,850 --> 01:01:31,910
+والمعصّلاتبتكون باتجاه معين والـ «مانوسايتز»
+
+545
+01:01:31,910 --> 01:01:32,770
+«مانوسايتز» «مانوسايتز» «مانوسايتز» «مانوسايتز»
+
+546
+01:01:32,770 --> 01:01:33,850
+«مانوسايتز» «مانوسايتز» «مانوسايتز» «مانوسايتز»
+
+547
+01:01:33,850 --> 01:01:34,950
+«مانوسايتز» «مانوسايتز» «مانوسايتز» «مانوسايتز»
+
+548
+01:01:34,950 --> 01:01:38,510
+«مانوسايتز» «مانوسايتز» «مانوسايتز» «مانوسايتز»
+
+549
+01:01:38,510 --> 01:01:39,650
+«مانوسايتز» «مانوسايتز» «مانوسايتز» «مانوسايتز»
+
+550
+01:01:39,650 --> 01:01:50,110
+«مانوسايتز» «مانوسايتز» «مانوسايتز» «مانوسايتز»
+
+551
+01:01:50,110 --> 01:01:55,090
+«مانوسايتز»
+
+552
+01:01:55,090 --> 01:01:59,170
+«مانوساوبمعرفة أيش المحددات اللي تمشي بهذا الاتجاه
+
+553
+01:01:59,170 --> 01:02:03,910
+يعني نتذكر إن الـ Red Blood Cells حتى تمشي الخلايا
+
+554
+01:02:03,910 --> 01:02:06,950
+وينكون Red Blood Cells بدنا هرمون الـ
+
+555
+01:02:06,950 --> 01:02:11,790
+Erythropoietin يعني أنا بحكي للواحد، بتذكر إن الـ
+
+556
+01:02:11,790 --> 01:02:17,210
+Erythropoietin عبارة عن هرمون بيشتغل على الخلايا
+
+557
+01:02:17,210 --> 01:02:21,930
+اللي هتصير Red Blood Cells طبعاً هو هرمون عبارة عن
+
+558
+01:02:21,930 --> 01:02:27,060
+بروتين وبدو يشتغل عن طريق Receptorفالـ Expression
+
+559
+01:02:27,060 --> 01:02:32,920
+وظهور الـ Receptor هو أول اختلال أو تغير بشوفه
+
+560
+01:02:32,920 --> 01:02:36,640
+بالـ Myeloid Progenitor عشان نعرف إن هاي راح تصير
+
+561
+01:02:36,640 --> 01:02:40,640
+Red Blood Cells بعدين لأن الخلية لازم تعرض الـ
+
+562
+01:02:40,640 --> 01:02:44,620
+Erythropoietin Receptor وبعدين الـ Erythropoietin
+
+563
+01:02:44,620 --> 01:02:50,540
+بيجي وبيكون إنه بيجبرها على إنه تروح بهذا الاتجاه
+
+564
+01:02:51,390 --> 01:02:57,230
+الـ Platelets، الـ «ترومبو بايتين» قالوا صاروا
+
+565
+01:02:57,230 --> 01:03:03,150
+لقوه كانوا يقولوا قبل الـ «إنترلوكن 11» مثلاً الـ
+
+566
+01:03:03,150 --> 01:03:07,850
+«مونوسايتس» والـ «T سيلز» والـ «B سيلز» كلهم تحت
+
+567
+01:03:07,850 --> 01:03:14,610
+أثير مؤشرات خارجية والمؤشرات الخارجية هذه الـ
+
+568
+01:03:14,610 --> 01:03:20,340
+External بتشتغل على Receptors والـ Receptorsتشتغل
+
+569
+01:03:20,340 --> 01:03:25,840
+جوا الخلية من خلال Activators معينين فكل هذه
+
+570
+01:03:25,840 --> 01:03:31,620
+الأنظمة سبحان الله أحياناً بتكون مسببة للأمراض
+
+571
+01:03:31,620 --> 01:03:36,640
+وضروري أننا نفهمها الآن
+
+572
+01:03:36,640 --> 01:03:45,880
+هناك يعني دفعة قوية لطريقة الاستفادة من قدرة
+
+573
+01:03:45,880 --> 01:03:55,350
+الخلايا على الإعطاءأعضاء وأنسجة بشكل مختلف وهي
+
+574
+01:03:55,350 --> 01:04:04,190
+قضية العلاج بالخلايا الجذعية جزء من قدرة الجسم على
+
+575
+01:04:04,190 --> 01:04:08,970
+تعويض نفسه وعلى بناء نفسه مرة ثانية وأعضاه وأجزته
+
+576
+01:04:08,970 --> 01:04:16,050
+بيكون من خلال الخلايا الجذعية هناك خلايا جذعية
+
+577
+01:04:16,050 --> 01:04:26,300
+يعنيحتى الخلايا الجذعية درجات وأنواع وكذا يعني إذا
+
+578
+01:04:26,300 --> 01:04:31,760
+مثلًا واحد عنده حرق واستطعت أجيب من جلده خلايا
+
+579
+01:04:31,760 --> 01:04:39,340
+جذعية جلدية اللي بدأت تتخصص باتجاه الجلد وأنا أكون
+
+580
+01:04:39,340 --> 01:04:45,660
+عنده قدرة على أني أكتشف أو أكون قد اكتشفتالمركبات
+
+581
+01:04:45,660 --> 01:04:51,060
+الهرمونية أو الدوافع لأن هذا الجلد يتكوّن هذا
+
+582
+01:04:51,060 --> 01:04:59,120
+الجلد يتكافر، هذا الجلد ينتشر فإذا استطعت أني أخذ
+
+583
+01:04:59,120 --> 01:05:06,120
+منه وأنشطه وأستخدمه
+
+584
+01:05:06,120 --> 01:05:10,840
+بعدين في قضية بناء الجسم مرة ثانية، هذا من أروع
+
+585
+01:05:10,840 --> 01:05:18,870
+الأشياءهناك طبعًا يعني جزء من الموضوع أنه لماذا
+
+586
+01:05:18,870 --> 01:05:25,550
+تدرس هذه القضايا أحيانًا أنه زي ما شُفنا بهذا
+
+587
+01:05:25,550 --> 01:05:34,570
+الشكل وشُفنا الصورة من قبل ممكن يعني هنا اللي هي
+
+588
+01:05:34,570 --> 01:05:43,270
+زي ما يُقال آليات التعامل مع الخلايا الجذعيةبكون
+
+589
+01:05:43,270 --> 01:05:53,130
+هنا يعني نوع من الـ suction نوع من الـ يعني عبارة
+
+590
+01:05:53,130 --> 01:05:59,470
+عن تفريغ هواء بحيث أنه تمسك القطع يعني زي الكرة
+
+591
+01:05:59,470 --> 01:06:06,410
+عاملةأو عمقود عنب مثلًا نسميه ممسوك بشكل مثبت وإله
+
+592
+01:06:06,410 --> 01:06:15,190
+بهذه القطعة وندخل إبرة تحت الميكروسكوب كل هذا نأخذ
+
+593
+01:06:15,190 --> 01:06:22,130
+عينة خلية واحدة ناخدها وندرسها فهذه إعلان
+
+594
+01:06:22,130 --> 01:06:26,530
+الإمكانات بالنسبة للخلايا الجدعية متقدمة ويمكن
+
+595
+01:06:26,530 --> 01:06:28,490
+الاستفادة منها
+
+596
+01:06:34,620 --> 01:06:40,440
+الاستفادة من الخلايا الجذعية في الخلايا الجسمانية
+
+597
+01:06:40,440 --> 01:06:49,020
+ماشي، يعني بالذات أنا ذكرت الأهم جانبين الخلايا
+
+598
+01:06:49,020 --> 01:06:53,520
+الجذعية ممكن تستفاد منها ولا يوجد عليها مشاكل أو
+
+599
+01:06:53,520 --> 01:06:59,840
+مشاكل الأمراضقضية نقلة الـ Thalassemia أو الـ
+
+600
+01:06:59,840 --> 01:07:03,800
+Hemoglobinopathies إن الواحد يعوض الجينات تبع الـ
+
+601
+01:07:03,800 --> 01:07:07,860
+Hemoglobin أو مثلًا أمراض نخصة من المناعة الأولية
+
+602
+01:07:07,860 --> 01:07:13,460
+Primary Immune Deficiencies هذه مثبتة وما فيش
+
+603
+01:07:13,460 --> 01:07:23,420
+عليها مشاكل لما الواحد يدخل في خلايامش Somatic،
+
+604
+01:07:23,420 --> 01:07:30,420
+عبارة عن ناقلة للمادة الورافية زي المبايد الخاصة،
+
+605
+01:07:30,420 --> 01:07:42,340
+الـTesticles، الـEmbryos بشكل مختلف بيصير هناك
+
+606
+01:07:42,340 --> 01:07:48,060
+إشكالات أخلاقية يجب أن ينتبه إليها الواحدحكينا
+
+607
+01:07:48,060 --> 01:07:52,500
+مثال من قبل على واحد استخدام الـ CRISPR وهو هذه
+
+608
+01:07:52,500 --> 01:07:59,220
+بتتعدل بطريقة مختلفة محاولة دراسة هذه النواحي مهمة
+
+609
+01:07:59,220 --> 01:08:06,080
+كثير ويلها تدخل في تطور الإنسان العلاقة لما نكون
+
+610
+01:08:06,080 --> 01:08:11,300
+نشوف
+
+611
+01:08:11,300 --> 01:08:23,710
+قضية إنه عبارة عنلمن يكون هناك توأم في الحمل نسبة
+
+612
+01:08:23,710 --> 01:08:32,150
+35% بيكونوا التوأمين
+
+613
+01:08:32,150 --> 01:08:41,870
+كل واحد منهم له كيس ماء ويعني تطور منفصل تماماً
+
+614
+01:08:41,870 --> 01:08:49,070
+هذا تقريباً نسبته 35%ولمّا العلبة تنقسم وتصبح
+
+615
+01:08:49,070 --> 01:08:56,330
+الـInners الماس اللي هو سيعطينا جسم الإنسان بيكون
+
+616
+01:08:56,330 --> 01:09:03,730
+ضمن نفس الكيس الواحد وينفصل إلى اتنين، هذا بيسمونه
+
+617
+01:09:03,730 --> 01:09:07,470
+«مونو كوريونيك» كوريونيك اللي هو الـAmmuniotic أو
+
+618
+01:09:07,470 --> 01:09:13,110
+الكوريون اللي هو طبقة المشيمة «Diamagnotic» بيكون
+
+619
+01:09:13,110 --> 01:09:21,560
+بهذا الشكلهذا بيكون إنه الإنفصال لجنينين شخصين راح
+
+620
+01:09:21,560 --> 01:09:30,480
+يصيروا بعدين في بعد التلقيح بأسبوع تقريبًا إذا كان
+
+621
+01:09:30,480 --> 01:09:37,760
+بعد الأسبوع بمدة أكبر بيكون ترتيب المشيلمة بشكل
+
+622
+01:09:37,760 --> 01:09:44,620
+مختلف وهذا عمليًا نادر جدًايعني اللي هي بالغلاق،
+
+623
+01:09:44,620 --> 01:09:49,120
+مرات، توائم، بيسموها سيامية أو بيكون مشتركة مع بعض
+
+624
+01:09:49,120 --> 01:10:00,740
+بشكل مختلف بس هنا ترتيب اللي هي ترتيب الـ… الـ…
+
+625
+01:10:00,740 --> 01:10:07,580
+الـMachine أو ترتيب قضية التطور للكائن الحي أو
+
+626
+01:10:07,580 --> 01:10:14,040
+الإنسان هناهناك يعني من الضواهر اللي ذكرنا عنها في
+
+627
+01:10:14,040 --> 01:10:22,340
+قضية التطور يعني اختلاف تركيب الجينات وأنا أتوقع
+
+628
+01:10:22,340 --> 01:10:31,620
+يعني لما نحاول الواحد يعني لما ذكرنا تطور الـ
+
+629
+01:10:31,620 --> 01:10:37,260
+Upper Limb في الـBird والـBird والـHuman وشوفنا
+
+630
+01:10:37,260 --> 01:10:43,270
+تشابههم واختلافهممش غلط الواحد يحاول يدرس المادة
+
+631
+01:10:43,270 --> 01:10:50,630
+الورافية تبعتها الإنسان مميز، 46 من الـChromosome
+
+632
+01:10:50,630 --> 01:10:57,750
+22 من الـSomatic أو الـAutosomal
+
+633
+01:10:57,750 --> 01:11:04,130
+والـX والـY، الـSix Chromosomes هذا الترتيب، حكات
+
+634
+01:11:04,130 --> 01:11:15,530
+منه تقريبًااللي يعني يقارب 95%، 95% يعني الأرقام
+
+635
+01:11:15,530 --> 01:11:21,070
+متفاوتة قليلاً «Non-coding DNA» ليش قيمة الجزء
+
+636
+01:11:21,070 --> 01:11:26,030
+القليل هو فقط اللي فيه المادة الوراثية للإنسان
+
+637
+01:11:26,030 --> 01:11:32,230
+وحوالي 25، 22، 25 ألف جين الموجودة في الإنسان كمان
+
+638
+01:11:32,230 --> 01:11:39,630
+جينا ندرس زي الـ Drosophilaاللي هي دبابة الفاكهة
+
+639
+01:11:39,630 --> 01:11:47,050
+دبابة الفاكهة الـ DNA حوالي أربع جينات فقط أربع،
+
+640
+01:11:47,050 --> 01:11:52,830
+آسف، أربع كرومزومات فقط يعني المادة الوراثية عندها
+
+641
+01:11:52,830 --> 01:11:57,650
+لا يوجد بينها فواصل زي ما بنتوقع عند الإنسان
+
+642
+01:11:57,650 --> 01:12:02,350
+المغالبية العظمة مالوش قيمة وRepeats وعبارة عن
+
+643
+01:12:02,350 --> 01:12:10,100
+جانب مالوش قيمةهكذا يُظن فلما
+
+644
+01:12:10,100 --> 01:12:18,200
+نجينا نشوف الأشياء المسؤولة عن تطور أماكن معينة
+
+645
+01:12:18,200 --> 01:12:22,920
+هنا مثلًا حتى على تطور الجهاز العصبي مثلًا بالنسبة
+
+646
+01:12:22,920 --> 01:12:32,640
+لترتيبة الأمور تجد أن هناك نوع من التشابههنا الـ
+
+647
+01:12:32,640 --> 01:12:37,640
+Human أو الـ Mouse بيكون بشكل معين عدد الـ Repeats
+
+648
+01:12:37,640 --> 01:12:43,220
+بيكون الجينات المسؤولة عن جانب معين بيكون مختلف
+
+649
+01:12:43,220 --> 01:12:52,840
+والفكرة أنه لما نرى المنطقة اللي هي سيتم نقلة
+
+650
+01:12:52,840 --> 01:12:59,560
+لإعطائنا بروتين معين حتى يتم قراءة هذا الجزء ماشي
+
+651
+01:12:59,560 --> 01:13:06,960
+بشكل سليميجب أن تحدث وتتدخّل جوانب كثيرة جدًا من
+
+652
+01:13:06,960 --> 01:13:14,240
+قبل فالـ «هرمون» اللي سي .. أو الأسف الـ «إنزايم»
+
+653
+01:13:14,240 --> 01:13:20,320
+اللي راح يكون الـ «RNA» من الـ «DNA» اللي يعمل
+
+654
+01:13:20,320 --> 01:13:24,760
+عملية الـ Transcription، ماشي؟ نسمي الـ «RNA»
+
+655
+01:13:24,760 --> 01:13:31,170
+Polymeraseفالـ RNA Polymerase راح يجي على الـ DNA
+
+656
+01:13:31,170 --> 01:13:36,730
+وراح يشوف المكان اللي هيقوله ابدا وهي تسمى الـ
+
+657
+01:13:36,730 --> 01:13:41,330
+Promoter Region منطقة الـ Promoter اللي هي بتتحكم
+
+658
+01:13:41,330 --> 01:13:46,790
+في الـ Transcription تبعت الـ DNA للـ Coding
+
+659
+01:13:46,790 --> 01:13:51,290
+Region اللي بتعطينا الـ RNA Transcript نتيجة هذا
+
+660
+01:13:51,290 --> 01:13:57,710
+الإنزين حتى هذا الإنزين يشتغل لازم يكون فيه لهعلى
+
+661
+01:13:57,710 --> 01:14:01,250
+الـ «Promoter Region» «General Transcription
+
+662
+01:14:01,250 --> 01:14:08,510
+Factors» فيه مُركّبات حتى تؤمر الـ «RNA» أنه يبدأ
+
+663
+01:14:08,510 --> 01:14:12,010
+من هنا ويبدأ عملية الـ Transcription وفيه
+
+664
+01:14:12,010 --> 01:14:17,470
+Activators وفيه Coactivators وأحيانًا بيكون فيه
+
+665
+01:14:17,470 --> 01:14:20,070
+طبعًا هذا يجب أن نسميه «مناطق» على الـ «DNA
+
+666
+01:14:20,070 --> 01:14:26,050
+Enhancers» يعني كلها عشان تهيأ أنه يتم قراءة هذا
+
+667
+01:14:26,050 --> 01:14:30,360
+الجانبويكون أحيانًا فيه repressor يعني فيه
+
+668
+01:14:30,360 --> 01:14:37,080
+inhibitors حتى أحيانًا بتكون موجودة فالفكرة اللي
+
+669
+01:14:37,080 --> 01:14:42,840
+بدنا ناخدها أنه حتى بعد حياة الإنسان يعني بعد
+
+670
+01:14:42,840 --> 01:14:48,660
+ولاته أي protein بتتم تنشيطه وعمله في مرحلة معينة
+
+671
+01:14:48,660 --> 01:14:57,080
+البداية راح تكونعلى مستوى الـ DNA البداية هتكون
+
+672
+01:14:57,080 --> 01:15:03,260
+بنظام دقيق مع عوامل كثيرة تنشط أو تثبت أو تحدد
+
+673
+01:15:03,260 --> 01:15:09,500
+القراءة يعني أن إنتاج أي بروتين أو RNA في هذه
+
+674
+01:15:09,500 --> 01:15:16,340
+الحالة بالضبط ليس قضية عشوائية، ليست قضية ذاتية من
+
+675
+01:15:16,340 --> 01:15:23,060
+حالها إنما هناك أوامر تحدث لإنها تطلب منهاحتى تعمل
+
+676
+01:15:23,060 --> 01:15:33,220
+هذا الأمر الـ… الأن على يعني حتى من كائنات حية زي
+
+677
+01:15:33,220 --> 01:15:43,060
+الدبابة المنطقة الأمامية، المنطقة الـ… الـDistal،
+
+678
+01:15:43,060 --> 01:15:49,060
+Proximal، Posterior، Anterior يعني حتى في نمو
+
+679
+01:15:49,060 --> 01:15:55,070
+الإنسان ونمو هذه الكائناتما هو الشيء اللي سيكون في
+
+680
+01:15:55,070 --> 01:15:57,630
+الأمام؟ ما هو الشيء اللي سيكون في الخلف؟ ما هو الـ
+
+681
+01:15:57,630 --> 01:16:00,550
+«على اليمين»؟ «على اليسار»؟ «الأقرب للمنتصف»؟
+
+682
+01:16:00,550 --> 01:16:08,090
+«الأبعد للمنتصف»؟ كل هذه هناك محددات وعوامل تنشيط
+
+683
+01:16:08,090 --> 01:16:13,950
+لتدفع الخلايا باتجاه معين فمثل على ذلك بالنسبة
+
+684
+01:16:13,950 --> 01:16:21,450
+للعظام يعني هنا حاطين صور اختلالاتورافية في الـ
+
+685
+01:16:21,450 --> 01:16:30,730
+Development of Bones فهنا الـ HOXD13 عبارة عن
+
+686
+01:16:30,730 --> 01:16:37,870
+مجموعة جينات وظيفتها تنشط الله أعلم البروتين اللي
+
+687
+01:16:37,870 --> 01:16:42,750
+بتكون مسئولة عن إنتاجه بس خلل في هذا المناطق من
+
+688
+01:16:42,750 --> 01:16:48,810
+الـ DNA تجعل هناك مشاكلاليدين هؤلاء، هتين، يعني
+
+689
+01:16:48,810 --> 01:16:55,470
+هنا الإبام ملتصقة ببعض ولم تنفصل، لم تتطور بالشكل
+
+690
+01:16:55,470 --> 01:17:03,290
+السليم بالنسبة للمرض اللي هو Polycystic Kidney
+
+691
+01:17:03,290 --> 01:17:13,550
+Disease عبارة عن مرض ضمني في الكبار Exlingued
+
+692
+01:17:13,550 --> 01:17:14,210
+Recessive
+
+693
+01:17:19,510 --> 01:17:27,130
+وبكون المشكلة الأساسية فيه أن الكيلة
+
+694
+01:17:27,130 --> 01:17:32,970
+بالذات ولكن غيرها من الأعضاء بيكون فيها حوائي صلات
+
+695
+01:17:32,970 --> 01:17:38,930
+فالحوائي صلات هذه بتتضخم بشكل يضغط على باقية أنسجة
+
+696
+01:17:38,930 --> 01:17:43,990
+الكيلية بحيث يسبب فشل الكلوة الـ Polycystic Kidney
+
+697
+01:17:43,990 --> 01:17:47,840
+Disease بيعمل فشل الكلوةبس لأنه الكلة كبيرة ويظل
+
+698
+01:17:47,840 --> 01:17:51,860
+يطلع الـ Erythropoietin فمايكونش فيه أنيميا يعني
+
+699
+01:17:51,860 --> 01:17:58,600
+أنا من الأسئلة لطلاب الطب أو لطباء بقولهم إيش هو
+
+700
+01:17:58,600 --> 01:18:03,340
+إذا مريض عنده facial callaway بس دمه كويس، شوستة
+
+701
+01:18:03,340 --> 01:18:10,420
+طبعاً، facial callaway مزمن وليس حادث، فلازم تكون
+
+702
+01:18:10,420 --> 01:18:14,330
+الإجابة في الغالب Polycystic Kidney Diseaseفالـ
+
+703
+01:18:14,330 --> 01:18:20,110
+Polycystic Kidney Disease بيكون
+
+704
+01:18:20,110 --> 01:18:26,890
+الهويصيلات هذه موجودة في شرين الدماغ، في
+
+705
+01:18:26,890 --> 01:18:33,210
+البنكرياز، في أماكن أخرى، مش بس الكلا يعني فالآن
+
+706
+01:18:33,210 --> 01:18:37,270
+لقينا إنه إشي بيسموه الـ Epidermal Growth Factor
+
+707
+01:18:37,270 --> 01:18:44,670
+Receptor EGFRماشي هو اللي بيكون فيه اختلال
+
+708
+01:18:44,670 --> 01:18:51,350
+وبالتالي يعني لقينا الجين المسؤول عن هذه الظاهرة
+
+709
+01:18:51,350 --> 01:19:00,010
+فهنا جميل إن الواحد يكون قادر على من الحالة
+
+710
+01:19:00,010 --> 01:19:07,450
+بمرض بشكل معين أرجع أعمل دراسة وراثية وجينية
+
+711
+01:19:07,450 --> 01:19:12,650
+وألاقي اختلال في الجين معينوأحاول أفسر كيف هذا
+
+712
+01:19:12,650 --> 01:19:19,670
+الأمر حصل كذلك في قضية الحالة
+
+713
+01:19:19,670 --> 01:19:26,510
+نادرة من قضية اسمها «Lysencephaly» «Lysencephaly»
+
+714
+01:19:26,510 --> 01:19:33,030
+أو «Lysencephalitis» دا في التهابس الدماغ نفسه
+
+715
+01:19:33,030 --> 01:19:43,290
+فهنا في حاطين تفاصيل أكثر عن الأمراضبيكون الاختلال
+
+716
+01:19:43,290 --> 01:19:48,270
+إنه قشرة
+
+717
+01:19:48,270 --> 01:19:57,270
+الدماغ بتكون بشكل بنقول «سن» وبنقول «عش» عنه «ملس»
+
+718
+01:19:57,270 --> 01:20:04,750
+وليس متعرج، ماشي؟ فالـ «إنسان سفلي» بيكون خلل في
+
+719
+01:20:04,750 --> 01:20:11,430
+الـ «development» تبع الخلايا العصبيةوهذه أحيانًا
+
+720
+01:20:11,430 --> 01:20:18,510
+يعني إذا رأينا كيف الإنسان بيتطور فطبعًا
+
+721
+01:20:18,510 --> 01:20:22,450
+التطور لازم يكون حكينا في أشياء بتوجه الخلايا
+
+722
+01:20:22,450 --> 01:20:28,470
+بتروح للجهة الأمامية البطنية أو الجهة الطهرية أو
+
+723
+01:20:28,470 --> 01:20:36,710
+الجهة الـ Media الأنسية والـ الـ الـ شو بيسموها؟
+
+724
+01:20:36,710 --> 01:20:42,900
+يعنيMedial وLateral الـ Medial اللي هي الجهة
+
+725
+01:20:42,900 --> 01:20:48,580
+الأنسية والـ Lateral الجهة الوحشية يعني المتوحش
+
+726
+01:20:48,580 --> 01:20:54,580
+بعيدة يعني فتطور الخلايا وهجرتها باتجاه السليم
+
+727
+01:20:54,580 --> 01:20:59,760
+ترتيبها بالشكل السليم الإنسان الطبيعي قشرة الدماغ
+
+728
+01:20:59,760 --> 01:21:04,140
+والدماغ بيكون مرتب بشكل طبقات بيكون بهذا الشكل
+
+729
+01:21:04,140 --> 01:21:12,390
+وبهذا الترتيبلقينا إنه فيه هرمو أو جين معين اللي
+
+730
+01:21:12,390 --> 01:21:20,130
+هو LIS1 L-I-S-1 mutation بيسبب إن الخلايا بتعرفش
+
+731
+01:21:20,130 --> 01:21:25,090
+تروح وين فهيك بتتجعلك و بتتخربط و مابتنتقلش بالشكل
+
+732
+01:21:25,090 --> 01:21:29,730
+المنتضن السليم اللي بيعطينا النمو الطبيعي للجهاز
+
+733
+01:21:29,730 --> 01:21:37,850
+العصبيالـ Less than cephaly هو حالة نتيجة اختلال
+
+734
+01:21:37,850 --> 01:21:43,290
+في هرمون أو في جين معين اللي هو «Less than one»
+
+735
+01:21:43,290 --> 01:21:47,950
+وبكون نتيجته إن الخلايا ماعرفتش كيف اتهاجر و أين
+
+736
+01:21:47,950 --> 01:21:50,950
+اتهاجر، كيف اتهاجر بالشكل السليم في الـ
+
+737
+01:21:50,950 --> 01:21:57,670
+Development فهناك تفاصيل كثيرة وحالات يعني
+
+738
+01:22:01,840 --> 01:22:09,000
+متعددة من إمكانات حدوث الاختلالات
+
+739
+01:22:09,000 --> 01:22:17,660
+التطورية والعيوب الخلقية الـ Birth Defects فالآن
+
+740
+01:22:17,660 --> 01:22:25,140
+هناك محاولة فهم أكبر للمحددات لهجرة الخلايا أو
+
+741
+01:22:25,140 --> 01:22:30,910
+لتعامل الخلايا وهذه بتفيدنا كما بنقول دائماًالجانب
+
+742
+01:22:30,910 --> 01:22:37,790
+الأول في قضية معرفة فهم المرض والقضية الثانية في
+
+743
+01:22:37,790 --> 01:22:44,630
+معرفة فهم احتمالات الأدوية واحتمالات العلاجات
+
+744
+01:22:44,630 --> 01:22:49,890
+واحتمالات معالجة الحالات المختلفة الله يعطيكم
+
+745
+01:22:49,890 --> 01:22:51,090
+الأعافية، في أسئلة
+
+746
+01:23:00,010 --> 01:23:05,710
+إن شاء الله خير ونلتقي إن شاء الله الأسبوع القادم
+
+747
+01:23:05,710 --> 01:23:10,850
+يوم الأربعة أنتم عندكم امتحان يوم الأثنين القادم
+
+748
+01:23:10,850 --> 01:23:15,090
+إن شاء الله نلتقي ومش راح يكون محاضرة جديدة بقدر
+
+749
+01:23:15,090 --> 01:23:20,650
+ما هي مراجعة استعدادة للامتحان ماشي الله يعطيكم
+
+750
+01:23:20,650 --> 01:23:21,430
+العافية
+
diff --git a/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/0znKCBWOhCg_postprocess.srt b/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/0znKCBWOhCg_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..c60e76236551b62468d87a8aafab6e288b43c784
--- /dev/null
+++ b/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/0znKCBWOhCg_postprocess.srt
@@ -0,0 +1,2096 @@
+1
+00:00:05,030 --> 00:00:07,870
+بسم الله الرحمن الرحيم السلام عليكم و رحمة الله و
+
+2
+00:00:07,870 --> 00:00:11,250
+بركاته اليوم هنبدأ بال chapter التالت في ال
+
+3
+00:00:11,250 --> 00:00:15,010
+machine design واحد اللي هو failures resulting
+
+4
+00:00:15,010 --> 00:00:19,670
+from static loading اللي هو الانهيارات او ال .. ال
+
+5
+00:00:19,670 --> 00:00:24,650
+.. ال .. في ال .. في القطع الميكانيكية نتيجة أحمال
+
+6
+00:00:24,650 --> 00:00:29,940
+ثابتةطبعا احنا ب chapter التلاتة و اربعة كان تحضير
+
+7
+00:00:29,940 --> 00:00:34,220
+ل chapter خمسة و chapter ستة، chapter تلاتة غطينا
+
+8
+00:00:34,220 --> 00:00:39,140
+كل حسابات ل stress analysis بكل أنواعها، ال .. ال
+
+9
+00:00:39,140 --> 00:00:45,530
+.. ال .. ال .. ال .. ال ..ال axel direct tensile
+
+10
+00:00:45,530 --> 00:00:49,310
+loading سواء كان tensile accommodation عند ال
+
+11
+00:00:49,310 --> 00:00:53,170
+bending loading عند ال transverse shear loading
+
+12
+00:00:53,170 --> 00:00:58,150
+عند ال torsional loading او any combination
+
+13
+00:00:58,150 --> 00:01:04,530
+between these loading conditions طبعا استخدمنا ال
+
+14
+00:01:04,530 --> 00:01:09,770
+more circle عشان احسب ال principal stresses
+
+15
+00:01:11,570 --> 00:01:15,830
+هذا شبتر تلاتة شبتر اربع غطينا ال deflection
+
+16
+00:01:15,830 --> 00:01:20,690
+calculations استخدمنا اللي هي ال strain energy
+
+17
+00:01:20,690 --> 00:01:24,090
+method و Castellano method to determine
+
+18
+00:01:24,090 --> 00:01:28,590
+deflections at various points on a mechanical
+
+19
+00:01:28,590 --> 00:01:31,930
+element اليوم هنكمل شبتر خمسة هنحكي عن failures
+
+20
+00:01:31,930 --> 00:01:35,430
+resulting from static loading هنحكي عن مجموعة من
+
+21
+00:01:35,430 --> 00:01:39,970
+النظريات المستخدمة في ال static loadingمنها ال
+
+22
+00:01:39,970 --> 00:01:41,930
+maximum normal stress theory و ال maximum shear
+
+23
+00:01:41,930 --> 00:01:45,070
+stress theory و ال maximum distortion energy
+
+24
+00:01:45,070 --> 00:01:48,450
+theory و ال columnar theory و ال modified columnar
+
+25
+00:01:48,450 --> 00:01:56,230
+theoryفي الأول هنعمل مراجعة على الحسابات ال stress
+
+26
+00:01:56,230 --> 00:01:59,950
+concentration due to sudden change in the cross
+
+27
+00:01:59,950 --> 00:02:02,410
+-sectional area طبعا sudden change في ال cross
+
+28
+00:02:02,410 --> 00:02:06,390
+-sectional area ممكن يكون due to different aspects
+
+29
+00:02:06,390 --> 00:02:10,570
+ممكن يكون في عندى ثقب او يكون عندى fillet طبعا
+
+30
+00:02:10,570 --> 00:02:15,350
+appendix A15 و A16 بيرجوني بيعطوني اللي هو
+
+31
+00:02:15,350 --> 00:02:18,350
+theoretical stress concentration factorsfor
+
+32
+00:02:18,350 --> 00:02:20,710
+different geometries and different loading
+
+33
+00:02:20,710 --> 00:02:26,350
+conditions على سبيل المثال figure a 15 1 في الكتاب
+
+34
+00:02:26,350 --> 00:02:32,410
+شجلي مبين ليه عند بار intention المقطع بتاعه
+
+35
+00:02:32,410 --> 00:02:38,290
+مستطيل وفيه ثقب في النص قطل الثقب دي small عرض
+
+36
+00:02:38,290 --> 00:02:44,170
+القطع w و البعد التالت لها T و under axial loading
+
+37
+00:02:44,170 --> 00:02:47,270
+على المحور الأفقي يكون عندي D على W
+
+38
+00:02:52,020 --> 00:03:01,240
+وهنا دي بيكون الكتي و ال nominal stress sigma o
+
+39
+00:03:01,240 --> 00:03:12,400
+بسوة F على A و ال A بالساوية اللي هي W minus D في
+
+40
+00:03:12,400 --> 00:03:18,720
+T W هي القطة هي
+
+41
+00:03:18,720 --> 00:03:19,580
+ال force F
+
+42
+00:03:22,970 --> 00:03:28,510
+هذا W هذا
+
+43
+00:03:28,510 --> 00:03:33,310
+D و
+
+44
+00:03:33,310 --> 00:03:37,270
+البعد التالت اللي
+
+45
+00:03:37,270 --> 00:03:40,930
+هو T
+
+46
+00:03:40,930 --> 00:03:47,190
+فانا بحسب بحسب ال net area اللي أخدت مقطع هنا
+
+47
+00:03:47,190 --> 00:03:50,450
+هيكون
+
+48
+00:03:50,450 --> 00:03:51,410
+عندى شكل المقطع
+
+49
+00:03:54,140 --> 00:04:07,060
+بالشكل هذا هاد
+
+50
+00:04:07,060 --> 00:04:14,360
+ال D هاد ال W هاد
+
+51
+00:04:14,360 --> 00:04:21,190
+ال H Tمن حد واضح ال net area هي ال area المضلة ده
+
+52
+00:04:21,190 --> 00:04:28,210
+هتكون اللي هو العرض في الارتفاع الارض دي W ناقص D
+
+53
+00:04:28,210 --> 00:04:32,210
+في T و
+
+54
+00:04:32,210 --> 00:04:36,670
+ال stress عند الثقب و لا عند ال hole sigma maximum
+
+55
+00:04:36,670 --> 00:04:43,090
+هيكون الساوية KT في Sigma
+
+56
+00:04:45,810 --> 00:04:50,550
+هذا one example another example في ال appendix
+
+57
+00:04:50,550 --> 00:04:53,890
+A159
+
+58
+00:04:53,890 --> 00:05:02,530
+في الكتاب فى مبين عندى mechanical element مقطع
+
+59
+00:05:02,530 --> 00:05:06,070
+مدور فى تغييف ال cross section من D small ل D
+
+60
+00:05:06,070 --> 00:05:06,610
+capital
+
+61
+00:05:16,620 --> 00:05:21,180
+و فيه بتأثير على ال bending moment بتأثير على ال
+
+62
+00:05:21,180 --> 00:05:25,280
+bending moment M و
+
+63
+00:05:25,280 --> 00:05:29,960
+فيه اندي fillet هنا ال
+
+64
+00:05:29,960 --> 00:05:35,400
+radius بتاعها R عشان احسب ال stress concentration
+
+65
+00:05:35,400 --> 00:05:40,420
+عند النقطة هذه بالزي
+
+66
+00:05:40,420 --> 00:05:44,360
+من ال two parameters اللي هو ال ratio بين ال
+
+67
+00:05:44,360 --> 00:05:52,970
+fillet radiusو small d وعندي هنا different cares
+
+68
+00:05:52,970 --> 00:05:55,850
+هذا ال cares بيعطوني
+
+69
+00:06:01,630 --> 00:06:08,130
+different D capital على D small يعني لو كنت أعرف D
+
+70
+00:06:08,130 --> 00:06:11,370
+capital على D small بختار كيرن الكيرفات هذه و أعرف
+
+71
+00:06:11,370 --> 00:06:14,830
+R على D مثلا لو كان D capital على D small بيستوى
+
+72
+00:06:14,830 --> 00:06:18,870
+تلاتة بحسب ال stress concentration KT بيطلع بيستوى
+
+73
+00:06:18,870 --> 00:06:25,570
+one point eight و ال sigma O في الحالة هذهبتساوي
+
+74
+00:06:25,570 --> 00:06:34,050
+طبعا هنا عند ال pure bending case sigma o بيساوي
+
+75
+00:06:34,050 --> 00:06:43,190
+M في C على I و C بيساوي D على 2 و I بيساوي Pi على
+
+76
+00:06:43,190 --> 00:06:53,770
+64 D اص 4 بتصفي sigma o بيساوي M
+
+77
+00:06:55,710 --> 00:07:08,290
+أتنين و تلاتين ام على باي دي تكيب والسيجما maximum
+
+78
+00:07:08,290 --> 00:07:16,850
+a due to stress concentration بساوي KT في السيجما
+
+79
+00:07:25,770 --> 00:07:28,370
+الان احنا هناخد في الاعتبار ال stress
+
+80
+00:07:28,370 --> 00:07:35,510
+concentration في حالتين حالة انه ال material بتاعة
+
+81
+00:07:35,510 --> 00:07:39,710
+ال mechanical element تكون ductile و الحالة
+
+82
+00:07:39,710 --> 00:07:41,650
+التانية ان ال material بتاعة ال mechanical element
+
+83
+00:07:41,650 --> 00:07:46,010
+تكون brittle الآن لو أخدنا الحالة هذه
+
+84
+00:08:05,270 --> 00:08:10,590
+هذه الـ shaft هذه
+
+85
+00:08:10,590 --> 00:08:15,110
+المحورة للـ shaft عندى
+
+86
+00:08:15,110 --> 00:08:25,010
+fillet هنا ر عند القطر هنا دي small عند
+
+87
+00:08:25,010 --> 00:08:25,930
+هذه دي capital
+
+88
+00:08:36,440 --> 00:08:38,920
+طبعا واضح انه فيه تغيير في ال cross section من D
+
+89
+00:08:38,920 --> 00:08:41,600
+small ل D capital وفيه عندى fillet radius R معناه
+
+90
+00:08:41,600 --> 00:08:45,580
+وفيه عندى stress concentration نفترض ان انا under
+
+91
+00:08:45,580 --> 00:08:54,740
+bending M و M due
+
+92
+00:08:54,740 --> 00:09:00,600
+to bending هسير فى المنطقة هى دى ال stress
+
+93
+00:09:00,600 --> 00:09:04,440
+distribution هيكون بالشكل هى ده
+
+94
+00:09:12,570 --> 00:09:17,350
+تحت هكون عندى tension و
+
+95
+00:09:17,350 --> 00:09:22,910
+هين هكون عندى compression
+
+96
+00:09:22,910 --> 00:09:31,230
+هين compression normal stress و tension normal
+
+97
+00:09:31,230 --> 00:09:36,430
+stress يعني لو أخدنا fiber هين if you take if you
+
+98
+00:09:36,430 --> 00:09:39,170
+take a fiber
+
+99
+00:09:42,980 --> 00:09:48,840
+الان لو ال moment وصلت لحد انه صار عندي هنا ال due
+
+100
+00:09:48,840 --> 00:09:50,720
+to stress كنت راشي انا sigma max
+
+101
+00:09:54,580 --> 00:09:59,420
+بسواكتي في sigma o ممكن ال sigma o does not reach
+
+102
+00:09:59,420 --> 00:10:03,560
+ال yielding لكن انا في الآخر هحس بال sigma maximum
+
+103
+00:10:03,560 --> 00:10:06,900
+ال local stress عند النقطة هذه sigma maximum
+
+104
+00:10:06,900 --> 00:10:11,380
+سواكتي في sigma o ممكن ال stress هين ادخل في ال ..
+
+105
+00:10:11,380 --> 00:10:14,140
+في ال plastic region يعني هسير عندي plastic
+
+106
+00:10:14,140 --> 00:10:20,380
+deformation يعني هسير yielding المنطقة هذه الطبقة
+
+107
+00:10:20,380 --> 00:10:26,590
+هذه و ال yieldالمادة ductile يعني مادة ايش طرية
+
+108
+00:10:26,590 --> 00:10:31,310
+due to yielding بيصيرها strain hardening او cold
+
+109
+00:10:31,310 --> 00:10:33,930
+work يعني ال strength بتاعتها بيزيد due to
+
+110
+00:10:33,930 --> 00:10:38,630
+yielding الان ال load هينتقل لل layer اللي بعدها
+
+111
+00:10:38,630 --> 00:10:43,230
+هينتقل لل layer .. للطبقة اللي بعدها وها كذا نتيجة
+
+112
+00:10:43,230 --> 00:10:47,930
+ان المادة مرنة تموت معاه فبيصير عنده
+
+113
+00:10:51,610 --> 00:10:56,550
+ال .. ال load is shared with other fibers معناته
+
+114
+00:10:56,550 --> 00:11:01,490
+ال .. ال .. ال material في الآخر بتريح .. بتريح
+
+115
+00:11:01,490 --> 00:11:06,810
+وبالتالي ال effect بتاع ال .. ال .. ال effect بتاع
+
+116
+00:11:06,810 --> 00:11:11,450
+ال stress concentration due to the fillet او due
+
+117
+00:11:11,450 --> 00:11:14,590
+to .. to change in cross section from D small to D
+
+118
+00:11:14,590 --> 00:11:15,350
+capital
+
+119
+00:11:18,000 --> 00:11:23,760
+تقريبا بتوزع على كل ال section نتيجة انه ال
+
+120
+00:11:23,760 --> 00:11:28,320
+yielding او ال load is shared among all the layers
+
+121
+00:11:28,320 --> 00:11:34,800
+of the body due to its ductility في الحالة هذه
+
+122
+00:11:34,800 --> 00:11:40,580
+stress concentration في حالة stress concentration
+
+123
+00:11:40,580 --> 00:11:48,770
+في حالة mechanical element thatis ductile and that
+
+124
+00:11:48,770 --> 00:11:54,070
+is under static loading بالحالة هذه بنهمل ال
+
+125
+00:11:54,070 --> 00:11:56,510
+effect بتاع ال stress concentration معناته إذا
+
+126
+00:11:56,510 --> 00:11:58,550
+كانت ال material بتاعة ال mechanical element
+
+127
+00:11:58,550 --> 00:12:03,530
+ductile وكان ال loading static بهمل ال stress
+
+128
+00:12:03,530 --> 00:12:10,170
+concentration effect هذا في حالة ductile material
+
+129
+00:12:15,210 --> 00:12:20,430
+لكن في حالة المادة كانت دكتايل و ال loading is not
+
+130
+00:12:20,430 --> 00:12:24,010
+static يعني ال loading is dynamic، dynamic loading
+
+131
+00:12:24,010 --> 00:12:28,330
+يعني ال loading مش ثابت، ال loading بتغير، في
+
+132
+00:12:28,330 --> 00:12:32,930
+الحالة هذه فش إمكانية أهمل ال stress
+
+133
+00:12:32,930 --> 00:12:35,230
+concentration، you have to take care of stress
+
+134
+00:12:35,230 --> 00:12:38,790
+concentration for a mechanical element that is
+
+135
+00:12:38,790 --> 00:12:43,210
+ductile and that is under dynamic loadingفي حالة
+
+136
+00:12:43,210 --> 00:12:48,470
+ال material كانت brittle I have to consider ال
+
+137
+00:12:48,470 --> 00:12:52,570
+stress concentration بغض النظر لو المادة كانت
+
+138
+00:12:52,570 --> 00:13:00,290
+ductile او brittleلأن ال material brittle قاسة جدا
+
+139
+00:13:00,290 --> 00:13:03,650
+ما بيصيرش عملية ال sharing between different
+
+140
+00:13:03,650 --> 00:13:05,870
+layers of the material يعني ال material النقطة
+
+141
+00:13:05,870 --> 00:13:08,950
+اللي صار فيها localized stress concentration او
+
+142
+00:13:08,950 --> 00:13:13,270
+localized plastic deformation فهي بتشيل كل ال
+
+143
+00:13:13,270 --> 00:13:18,550
+loading and it does not shareor it does not
+
+144
+00:13:18,550 --> 00:13:20,770
+distribute .. the load is not distributed among
+
+145
+00:13:20,770 --> 00:13:25,150
+other layers وبالتالي انا ممكن اصل ال ultimate
+
+146
+00:13:25,150 --> 00:13:29,950
+tensile strength او عند النقطة هذه ويصير عندي
+
+147
+00:13:29,950 --> 00:13:33,390
+sudden failure وبالتالي ال stress concentration
+
+148
+00:13:33,390 --> 00:13:36,930
+effect must be included for a brittle material
+
+149
+00:13:36,930 --> 00:13:45,210
+whether the loading is static or dynamic طيب
+
+150
+00:13:59,340 --> 00:14:03,520
+لما كان هنا uniaxial stress element uniaxial يعني
+
+151
+00:14:03,520 --> 00:14:09,440
+هاي stress element وهي
+
+152
+00:14:09,440 --> 00:14:15,980
+عليه force sigma هاي sigma لو رصدت ال stress
+
+153
+00:14:15,980 --> 00:14:21,080
+strain curve لهذا ال element هيكون بشكل هذا تقريبا
+
+154
+00:14:21,080 --> 00:14:26,100
+هذا strain هذا sigma وكنا نحسب
+
+155
+00:14:30,590 --> 00:14:37,390
+هذا point to strength percent و هذا كان sigma
+
+156
+00:14:37,390 --> 00:14:44,930
+yield و هذا sigma او
+
+157
+00:14:44,930 --> 00:14:49,970
+S yield ال yield strength و ال ultimate strength S
+
+158
+00:14:49,970 --> 00:15:00,390
+yield و S ultimate لو حكينا هذا هو ال actualstate
+
+159
+00:15:00,390 --> 00:15:04,370
+of stress هذه ال sigma كنا نحصل factor of safety n
+
+160
+00:15:04,370 --> 00:15:12,490
+بصوة ال strength على sigma هذا في حالة uniaxial
+
+161
+00:15:12,490 --> 00:15:17,650
+stress element لكن
+
+162
+00:15:17,650 --> 00:15:23,140
+على أرض الواقعمش بالضرورة أو في أعظم الأحيان
+
+163
+00:15:23,140 --> 00:15:27,340
+بيكونش ال state of stress يعني أكسل في معظم
+
+164
+00:15:27,340 --> 00:15:30,640
+الأحيان بتكون ال stress of stress is
+
+165
+00:15:30,640 --> 00:15:35,740
+multidimensional يعني ممكن كنت لو اتطلع على ال 3D
+
+166
+00:15:35,740 --> 00:15:40,560
+stress element عندى هنا sigma x sigma y sigma z
+
+167
+00:15:40,560 --> 00:15:45,940
+tau xy tau xz tau yz يعني في عندى كل أنواع ال
+
+168
+00:15:45,940 --> 00:15:48,100
+loading conditions موجودة
+
+169
+00:15:50,110 --> 00:15:55,230
+السؤال how to compare .. how to compare this state
+
+170
+00:15:55,230 --> 00:15:59,150
+of stress with a single strength لأن في الأخر ..
+
+171
+00:15:59,150 --> 00:16:02,310
+النهاية .. في النهاية ال material لها strength
+
+172
+00:16:02,310 --> 00:16:07,010
+واحدة ال material كمaterial لها strength واحدة لكن
+
+173
+00:16:07,010 --> 00:16:11,550
+ال .. ال .. ال element ممكن يكون بتعرض ل
+
+174
+00:16:11,550 --> 00:16:18,190
+multistate of stress معناته
+
+175
+00:16:18,190 --> 00:16:25,590
+انا عنديone strength one strength عندي multiple
+
+176
+00:16:25,590 --> 00:16:30,110
+state of stress يعني انا عندي معضلة كيف بده ا ..
+
+177
+00:16:30,110 --> 00:16:34,450
+بده اقارن one strength and multiple stress هذا
+
+178
+00:16:34,450 --> 00:16:41,430
+سؤال نسأله محتاجين لإجابة عليه how to compare one
+
+179
+00:16:41,430 --> 00:16:43,730
+strength of the material of the mechanical element
+
+180
+00:16:43,730 --> 00:16:46,050
+with a multiple state of stress
+
+181
+00:16:50,020 --> 00:16:54,740
+الإجابة بتيجي من انه عشان هيك احنا نحتاج ل static
+
+182
+00:16:54,740 --> 00:16:59,480
+failure theory ال failure theory بتقترح علينا
+
+183
+00:16:59,480 --> 00:17:06,020
+appropriate means طريقة للمقارنة بين multi axial
+
+184
+00:17:06,020 --> 00:17:11,040
+state of stress to single strength معناته ال
+
+185
+00:17:11,040 --> 00:17:16,820
+design theories او ال failure theories proposean
+
+186
+00:17:16,820 --> 00:17:20,080
+appropriate means appropriate means to compare
+
+187
+00:17:20,080 --> 00:17:25,980
+multi axial state of stress to a single strength
+
+188
+00:17:25,980 --> 00:17:33,280
+هذا اللي بيجيب على السؤال تبعنا الان ملخص ال
+
+189
+00:17:33,280 --> 00:17:38,820
+chapter تاني اللي حتى اللي كنا تحضير هذا flow
+
+190
+00:17:38,820 --> 00:17:47,610
+diagram ل design for static loading هنمشي عليهأول
+
+191
+00:17:47,610 --> 00:17:51,910
+شي لازم أعرف أنا ال material is ductile or brittle
+
+192
+00:17:51,910 --> 00:18:00,610
+فين فين دي I question I check أبسلون F من stress
+
+193
+00:18:00,610 --> 00:18:01,650
+strain curve
+
+194
+00:18:06,950 --> 00:18:12,190
+أبسلون F هو ال strain at failure يعني أنا بضلني
+
+195
+00:18:12,190 --> 00:18:16,110
+أشد أشد element بيصير فيه deformation لحد الكسر
+
+196
+00:18:16,110 --> 00:18:21,390
+معناته أبسلون F is representative of the ductility
+
+197
+00:18:21,390 --> 00:18:23,750
+of the material إذا كانت أبسلون F كبيرة كتير
+
+198
+00:18:23,750 --> 00:18:27,510
+معناته ال material is ductile إذا أبسلون F صغيرة
+
+199
+00:18:27,510 --> 00:18:34,130
+معناته ال material is brittleالان كبيرة كتير او
+
+200
+00:18:34,130 --> 00:18:37,910
+صغيرة كتير هذا اشي نسبي معناته I have to define
+
+201
+00:18:37,910 --> 00:18:46,170
+some border line اذا كانت F أكبر او يساوي point أو
+
+202
+00:18:46,170 --> 00:18:55,910
+خمسة معناته ال material is ductile اذا
+
+203
+00:18:55,910 --> 00:18:58,830
+كانت أقل من point أو خمسة معناته ال material is
+
+204
+00:18:58,830 --> 00:18:59,270
+brittle
+
+205
+00:19:10,220 --> 00:19:13,580
+معناته إذا ال material is ductile ال flow chart
+
+206
+00:19:13,580 --> 00:19:17,280
+بروح على جهة اليمين إذا كانت brittle بروح على
+
+207
+00:19:17,280 --> 00:19:25,240
+الجهة الشمالة الآن في الجهة دي احنا حكينا we are
+
+208
+00:19:25,240 --> 00:19:29,940
+dealing with a ductile material او انا في عندى
+
+209
+00:19:29,940 --> 00:19:33,420
+cheeks تانية في فحوصات تانية بدي أشوف هل ال yield
+
+210
+00:19:33,420 --> 00:19:36,980
+strength in tension بتساوي ال yield strength in
+
+211
+00:19:36,980 --> 00:19:42,110
+compression بدي أفحص أشوفهل ال yield strength in
+
+212
+00:19:42,110 --> 00:19:46,970
+tension بيستوي ال yield strength in compression طب
+
+213
+00:19:46,970 --> 00:19:54,510
+يا اما هتسويها او مش هتسويها yes او no اذا كانت ال
+
+214
+00:19:54,510 --> 00:19:58,470
+yield strength in tension بتستوي ال yield strength
+
+215
+00:19:58,470 --> 00:20:03,310
+in compression بدى اقرر هل انا بدي conservative
+
+216
+00:20:03,310 --> 00:20:09,450
+results يعني قيم و حسابات محافظة ولا accurate
+
+217
+00:20:09,450 --> 00:20:14,790
+resultsفانا بسأل نفسي do I need conservative
+
+218
+00:20:14,790 --> 00:20:18,670
+results؟
+
+219
+00:20:18,670 --> 00:20:23,450
+يعني أنا عنصر ال conservative يعني عنصر المخاطرة
+
+220
+00:20:23,450 --> 00:20:29,250
+في حساباتي بيكون أقل if I need more conservative
+
+221
+00:20:29,250 --> 00:20:37,530
+results ممكن استخدم ما يسمى ال maximum shear
+
+222
+00:20:37,530 --> 00:20:44,240
+stress theoryif I need more accurate results which
+
+223
+00:20:44,240 --> 00:20:48,680
+is less conservative كل ما بزيد عندي الدقة كل ما
+
+224
+00:20:48,680 --> 00:20:52,980
+أنصر مخاطرة بزيد عندي if I need more accurate
+
+225
+00:20:52,980 --> 00:20:57,480
+results less conservative results بستخدم في الحالة
+
+226
+00:20:57,480 --> 00:21:03,000
+هذه ال distortion energy theory اللي هنجيها بعدين
+
+227
+00:21:05,150 --> 00:21:08,390
+أنا في ال .. أنا جوابت على السؤال الحالة هذه إذا
+
+228
+00:21:08,390 --> 00:21:10,850
+أسوء ال .. ال yield strength in tension بالسواء
+
+229
+00:21:10,850 --> 00:21:14,170
+yield strength in compression بدي أشوف إذا انا بدي
+
+230
+00:21:14,170 --> 00:21:18,510
+conservative results يعني ال risk أقل بستخدم
+
+231
+00:21:18,510 --> 00:21:21,470
+maximum share stress theory إذا بدي more accurate
+
+232
+00:21:21,470 --> 00:21:27,450
+results ال risk أكتر بستخدم storage energy theory
+
+233
+00:21:28,420 --> 00:21:31,800
+في حالة كانت الـ lead strength in tension بتسويش
+
+234
+00:21:31,800 --> 00:21:35,320
+lead strength in compression بستخدم ما يسمى الـ
+
+235
+00:21:35,320 --> 00:21:39,180
+Ductile Coulomb-Moore Theory Ductile Coulomb-Moore
+
+236
+00:21:39,180 --> 00:21:42,840
+Theory اللي هي معادلة 5.26 في الكتابة
+
+237
+00:21:47,980 --> 00:21:51,200
+أنا في الحلقة دي علجت اللي هو حالة ductile
+
+238
+00:21:51,200 --> 00:21:56,200
+materials إذا كانت ال material brittle يعني F أقل
+
+239
+00:21:56,200 --> 00:22:02,220
+من point O5 بدي أقرر if I need conservative
+
+240
+00:22:02,220 --> 00:22:03,040
+results
+
+241
+00:22:08,380 --> 00:22:11,120
+يعني إذا بدي conservative results يعني المعنصر
+
+242
+00:22:11,120 --> 00:22:14,000
+المخاطر في الحسابات تكون أقل بروح على الجهة اليمين
+
+243
+00:22:14,000 --> 00:22:18,760
+إذا بدي more accurate less conservative يعني دقة
+
+244
+00:22:18,760 --> 00:22:22,680
+أعلى مع مخاطرة أكتر في الحسابات بروح على الجهة
+
+245
+00:22:22,680 --> 00:22:26,000
+الشمال بنتقل if I need conservative results بستخدم
+
+246
+00:22:26,000 --> 00:22:30,240
+ال brittle column more theory ال brittle column
+
+247
+00:22:30,240 --> 00:22:36,600
+more theoryإذا بدي انا more accurate results less
+
+248
+00:22:36,600 --> 00:22:43,980
+conservative بستخدم ال modified more theory هذه
+
+249
+00:22:43,980 --> 00:22:48,260
+خارطة الطريق لكل شبطر هذه خارطة الطريق لكل شبطر
+
+250
+00:22:49,500 --> 00:22:54,060
+الكتاب عرضها في آخر ال chapter انا شايف احسن انه
+
+251
+00:22:54,060 --> 00:22:56,740
+عرضها في بداية ال chapter و آخر ال chapter هعرض
+
+252
+00:22:56,740 --> 00:23:00,700
+نفس الخارطة هذه عشان نرجع الشغل اللي اشتغلناه طبعا
+
+253
+00:23:00,700 --> 00:23:04,840
+انا هنا عرضت flow chart هذا كل ال chapter هكون ..
+
+254
+00:23:04,840 --> 00:23:08,020
+هنحكي على اللي هو ال maximum shear stress theory
+
+255
+00:23:08,020 --> 00:23:10,120
+ال distortion inequality theory ال ductile column
+
+256
+00:23:10,120 --> 00:23:12,140
+wall theory ال brittle column wall theory و ال
+
+257
+00:23:12,140 --> 00:23:15,100
+modified wall theory هذه كلها هتتغطى في هذا ال
+
+258
+00:23:15,100 --> 00:23:15,360
+chapter
+
+259
+00:23:19,860 --> 00:23:26,220
+نبدأ في ال theories المستخدمة في static loading
+
+260
+00:23:26,220 --> 00:23:36,300
+design اول
+
+261
+00:23:36,300 --> 00:23:40,340
+theory هي maximum normal stress theory هنموذجها
+
+262
+00:23:40,340 --> 00:23:44,860
+برمز MNS maximum normal stress theory ال maximum
+
+263
+00:23:44,860 --> 00:23:48,440
+normal stress theory بتحكي التالي بتحكي انهالـ
+
+264
+00:23:48,440 --> 00:23:51,860
+yielding begins يعني ببدأ ال mechanical element
+
+265
+00:23:51,860 --> 00:23:57,920
+يدخل ل plastic range when لما ال maximum principle
+
+266
+00:23:57,920 --> 00:24:02,000
+stress in a stress element exceeds the yield
+
+267
+00:24:02,000 --> 00:24:08,860
+strength ببدأ يصير yielding لما ال maximum
+
+268
+00:24:08,860 --> 00:24:14,660
+principle stress in a stress elementبتخطأ ال yield
+
+269
+00:24:14,660 --> 00:24:18,500
+strength ال material في الحالة هذه بحكي ان ال part
+
+270
+00:24:18,500 --> 00:24:24,020
+is .. ال part fails part fails بيصير فيلر ال part
+
+271
+00:24:24,020 --> 00:24:27,140
+معناته according to maximum normal stress theory
+
+272
+00:24:27,140 --> 00:24:31,260
+ال yielding بيبدأ لما ال maximum principle stress
+
+273
+00:24:31,260 --> 00:24:35,960
+in a stress element بتخطأ ال yield strength of the
+
+274
+00:24:35,960 --> 00:24:41,220
+materialطبعا انا بستخدم في chapter تلاتة استخدمنا
+
+275
+00:24:41,220 --> 00:24:44,360
+ال column الاستخدامنا more circle to find the
+
+276
+00:24:44,360 --> 00:24:47,700
+principal series اذا كنا نحسب sigma واحد و sigma
+
+277
+00:24:47,700 --> 00:24:51,920
+اتنين و sigma تلاتة كنا نرتبهم بحيث يكون sigma
+
+278
+00:24:51,920 --> 00:24:58,480
+واحد اكبر من sigma اتنين اكبر من sigma تلاتة
+
+279
+00:24:58,480 --> 00:25:07,470
+معناته sigma واحدإذا كان سجن واحد أكبر أو يساوي
+
+280
+00:25:07,470 --> 00:25:12,870
+الأسوار في حالة الـ Ductile Material بيصير MDH
+
+281
+00:25:12,870 --> 00:25:14,150
+فاليار
+
+282
+00:25:21,040 --> 00:25:24,440
+هذه هي ال principle أو ال maximum normal stress
+
+283
+00:25:24,440 --> 00:25:27,860
+theory بتحكي بيصير yielding لما ال maximum
+
+284
+00:25:27,860 --> 00:25:32,960
+principle stress في mechanical element بيكون أكبر
+
+285
+00:25:32,960 --> 00:25:35,780
+أو يساوي lead strength of that mechanical element
+
+286
+00:25:35,780 --> 00:25:39,580
+في الحالة هذه بيصير عندي إيه؟ failure otherwise
+
+287
+00:25:39,580 --> 00:25:45,700
+مافيش failure عندنا يعني
+
+288
+00:25:45,700 --> 00:25:47,680
+لو أخدنا ال two-D state of stress
+
+289
+00:25:51,200 --> 00:26:00,260
+سيكون عندي سيجما واحد و هي سيجما اتنين سيجما واحد
+
+290
+00:26:00,260 --> 00:26:05,320
+اللي هي ال first principle stress و سيجما اتنين هي
+
+291
+00:26:05,320 --> 00:26:10,020
+second principle stress إذا قسمت سيجما واحد على SY
+
+292
+00:26:10,020 --> 00:26:14,620
+و هي سيجما اتنين على SY
+
+293
+00:26:18,860 --> 00:26:23,020
+يعني إذا كان ال sigma 1 على SY يعني إذا كان sigma
+
+294
+00:26:23,020 --> 00:26:27,860
+1 بيساوي SY يعني sigma 1 على SY بيساوي إيش؟ واحد
+
+295
+00:26:27,860 --> 00:26:32,520
+إذا
+
+296
+00:26:32,520 --> 00:26:40,200
+كان sigma 1 على SY أكبر أو يساوي واحد بيصير عندي
+
+297
+00:26:40,200 --> 00:26:45,240
+إيش؟ failure يعني إذا كنت في هذا الاتجاه من هذا
+
+298
+00:26:45,240 --> 00:26:48,140
+النقطة وامشي بيصير عندي
+
+299
+00:26:57,390 --> 00:27:06,770
+failure طبعا هذا يمثل ال
+
+300
+00:27:06,770 --> 00:27:14,770
+failure contour لل
+
+301
+00:27:14,770 --> 00:27:15,790
+mechanical element
+
+302
+00:27:32,700 --> 00:27:37,300
+جوا المستطيل no
+
+303
+00:27:37,300 --> 00:27:42,940
+failure برا
+
+304
+00:27:42,940 --> 00:27:48,570
+المستطيلفي failure يعني هنا .. هنا برا failure جوا
+
+305
+00:27:48,570 --> 00:27:52,850
+safe انبيني هنا experimental data experimental
+
+306
+00:27:52,850 --> 00:27:57,850
+data عشان أشوف هل النظرية بتحقق الاشياء يعني
+
+307
+00:27:57,850 --> 00:28:03,010
+متوافقة مع الواقع ولا لأ لأن انبيني عندي في المربع
+
+308
+00:28:03,010 --> 00:28:05,990
+الأول إذا كان سجم واحد موجبة أو سجم اتنين موجبة
+
+309
+00:28:05,990 --> 00:28:11,790
+بيكون ال .. ال experimental data يعني ممكن اعتبرها
+
+310
+00:28:11,790 --> 00:28:21,270
+fits ال theoryبشكل دقيق وبشكل كافي لكن في الربيع
+
+311
+00:28:21,270 --> 00:28:25,030
+الرابع اذا كان sigma 1 موجبة و sigma 2 سالبة
+
+312
+00:28:25,030 --> 00:28:28,810
+لاحظوا
+
+313
+00:28:28,810 --> 00:28:35,890
+انه في الحقيقة لو حكينا هذا هو ال load line في
+
+314
+00:28:35,890 --> 00:28:44,480
+الحقيقة we reach failure احنا وصلنا لل failureو
+
+315
+00:28:44,480 --> 00:28:47,960
+لسه النظرية بتحكيلي لأ انت وضعك كويس مش failure
+
+316
+00:28:47,960 --> 00:28:52,500
+بتحكي عشان تصير failure ده تصار النقطة هادئ لكن
+
+317
+00:28:52,500 --> 00:28:55,840
+انا في الحقيقة عرض الواقع صار failure معناته
+
+318
+00:28:55,840 --> 00:29:00,060
+النظرية في الرابع الرابع بتخدعني بتعطينيش اشي دقيق
+
+319
+00:29:00,060 --> 00:29:07,430
+وبالتالي it's not safe to use this theoryfor
+
+320
+00:29:07,430 --> 00:29:11,830
+ductile material لسبب بسيط لأنه it does not fit او
+
+321
+00:29:11,830 --> 00:29:14,870
+it does not predict the experimental case
+
+322
+00:29:14,870 --> 00:29:20,130
+experimental case بتحكي ان انا بصير failure while
+
+323
+00:29:20,130 --> 00:29:25,070
+the maximum stress theory says that it is safe
+
+324
+00:29:25,070 --> 00:29:31,290
+failures does not reach yet it is reach yet في
+
+325
+00:29:31,290 --> 00:29:35,850
+الحقيقة لكن طبق النظرية لأ موصلناش لأن ذلك معناته
+
+326
+00:29:35,850 --> 00:29:45,450
+انا باخدنتائج او بحكي نتائج خادعة فمعناته يعني
+
+327
+00:29:45,450 --> 00:29:50,110
+صارت النظرية بس استيراد تاريخي مش هنستخدمه في
+
+328
+00:29:50,110 --> 00:29:54,290
+الحسابات بتاعتنا النظرية
+
+329
+00:29:54,290 --> 00:30:02,530
+التانيةاللي هي ال maximum shear stress theory ال
+
+330
+00:30:02,530 --> 00:30:07,150
+maximum
+
+331
+00:30:07,150 --> 00:30:12,630
+shear stress theory بتحكي التالي بيبدأ
+
+332
+00:30:12,630 --> 00:30:16,270
+ال material تدخل ال plastic range تبدأش تمغط معاه
+
+333
+00:30:16,270 --> 00:30:22,990
+لما ال maximum shear stress in a stress element
+
+334
+00:30:24,390 --> 00:30:28,950
+بيكون أكبر أو يساوي ال maximum shear stress in a
+
+335
+00:30:28,950 --> 00:30:32,450
+tensile test specimen اللي له نفس المادة بتاعة ال
+
+336
+00:30:32,450 --> 00:30:37,090
+mechanical element المعنى عشان maximum shear
+
+337
+00:30:37,090 --> 00:30:40,830
+stress يبتحك التالي يبتحك بيصير failure أو يصير
+
+338
+00:30:40,830 --> 00:30:45,310
+yielding أو المادة بتدخل في ال plastic rangeلما ال
+
+339
+00:30:45,310 --> 00:30:50,510
+maximum shear stress في ال actual element بتخطى،
+
+340
+00:30:50,510 --> 00:30:54,730
+بتكون أكبر أو يساوي ال maximum shear stress in a
+
+341
+00:30:54,730 --> 00:30:57,690
+tensile test specimen، ال tensile test specimen
+
+342
+00:30:57,690 --> 00:31:05,810
+بيكون متعرض ل axial loading، sigma و sigma، لو ادي
+
+343
+00:31:05,810 --> 00:31:07,470
+ارسم ال more circle له
+
+344
+00:31:13,220 --> 00:31:23,640
+سيكون بالشكل هذا مار سيركل هذا سجن واحد وهذا زرن
+
+345
+00:31:23,640 --> 00:31:30,600
+سجن اتنين وهذا تاو ماكسيمم الفشل سجن واحد سيكون
+
+346
+00:31:30,600 --> 00:31:38,980
+اسواء اسواء معناته تاو ماكسيمم سيكون اسواء اسواء
+
+347
+00:31:40,220 --> 00:31:46,980
+على اتنين in a tensile test
+
+348
+00:31:46,980 --> 00:31:56,460
+specimen يعني
+
+349
+00:31:56,460 --> 00:32:00,460
+ممكن نصيحها بطريقة تانية نحكي according to maximum
+
+350
+00:32:00,460 --> 00:32:05,680
+shear stress theory failure begins when yielding
+
+351
+00:32:05,680 --> 00:32:07,520
+begins or yielding begins
+
+352
+00:32:10,310 --> 00:32:19,490
+بصير لما ال tau maximum تكون أكبر أو يساوي S Y على
+
+353
+00:32:19,490 --> 00:32:30,490
+اتنين احنا
+
+354
+00:32:30,490 --> 00:32:35,350
+more silky في هذا ال tensile بشكل عام بشكل عام
+
+355
+00:32:37,770 --> 00:32:42,130
+بتكون دي more circle بالشكل هذا هذا ال sigma واحد
+
+356
+00:32:42,130 --> 00:32:46,430
+هذا
+
+357
+00:32:46,430 --> 00:32:50,370
+ال 3D more circle sigma واحد sigma اتنين sigma
+
+358
+00:32:50,370 --> 00:32:54,850
+تلاتة انا برتب بحيث sigma واحد اكبر من sigma اتنين
+
+359
+00:32:54,850 --> 00:32:59,350
+اكبر من sigma تلاتة و احنا عرفنا سابقا حكينا ال
+
+360
+00:32:59,350 --> 00:33:05,650
+tau maximum بالساوية sigma واحد minus sigma تلاتة
+
+361
+00:33:05,650 --> 00:33:11,130
+على اتنينو according to ال maximum share history
+
+362
+00:33:11,130 --> 00:33:14,670
+theory بيصير failure او بيصير yielding لما انتهى
+
+363
+00:33:14,670 --> 00:33:15,190
+maximum
+
+364
+00:33:18,660 --> 00:33:23,760
+بتكون اكبر او يساوي as y على اتنين يعني ال maximum
+
+365
+00:33:23,760 --> 00:33:28,880
+هي sigma واحد minus sigma تلاتة على اتنين اكبر او
+
+366
+00:33:28,880 --> 00:33:33,280
+يساوي as y على اتنين يعني لو اختصرت اتنين مع اتنين
+
+367
+00:33:33,280 --> 00:33:37,420
+بتكون sigma واحد minus sigma تلاتة اكبر او يساوي
+
+368
+00:33:37,420 --> 00:33:39,240
+as y
+
+369
+00:33:43,280 --> 00:33:48,160
+يعني exactly at failure exactly at failure بتكون
+
+370
+00:33:48,160 --> 00:33:54,740
+tau maximum بالسواء أسواء على اتنين إذا أنا مابديش
+
+371
+00:33:54,740 --> 00:33:57,880
+يصير failure إذا مابديش يصير failure بحط factor of
+
+372
+00:33:57,880 --> 00:34:03,840
+safety بصير tau maximum to avoid failure بالسواء
+
+373
+00:34:03,840 --> 00:34:08,600
+أسواء على اتنين and و and factor of safety
+
+374
+00:34:16,320 --> 00:34:33,260
+الان هناخد ال maximum share stress theory هناخد
+
+375
+00:34:33,260 --> 00:34:37,740
+2D state of stress
+
+376
+00:34:42,320 --> 00:34:45,440
+يعني two destate of stress هيكون اتنين من ال
+
+377
+00:34:45,440 --> 00:34:50,120
+principal stresses اللي هم قيم و ال principal
+
+378
+00:34:50,120 --> 00:34:52,800
+stress في التالت هيكون ساوة صفر يعني هيكون عندى
+
+379
+00:34:52,800 --> 00:34:56,280
+sigma واحد و sigma اتنين و sigma تلاتة موجودين بس
+
+380
+00:34:56,280 --> 00:35:00,620
+واحد من التلاتة ده هيكون عاشر ساوة صفر معناته عند
+
+381
+00:35:00,620 --> 00:35:06,560
+plain stress state ال sigma a و ال sigma b مثله
+
+382
+00:35:06,560 --> 00:35:08,540
+اللي هو two non zero principal stresses
+
+383
+00:35:11,500 --> 00:35:14,160
+هحسب من more circles سيجما واحد و سيجما اتنين و
+
+384
+00:35:14,160 --> 00:35:17,800
+سيجما تلاتة او ارتبهم ترتيب تصعدي بحيث يكون عنده
+
+385
+00:35:17,800 --> 00:35:23,400
+سيجما واحد اكبر من سيجما اتنين اكبر من سيجما تلاتة
+
+386
+00:35:23,400 --> 00:35:26,680
+او اكبر من سيجما تلاتة او اكبر من سيجما تلاتة او
+
+387
+00:35:26,680 --> 00:35:28,760
+اكبر من سيجما تلاتة او اكبر من سيجما تلاتة او اكبر
+
+388
+00:35:28,760 --> 00:35:31,220
+من سيجما تلاتة او اكبر من سيجما تلاتة او اكبر من
+
+389
+00:35:31,220 --> 00:35:35,500
+سيجما تلاتة او اكبر من سيجما تلاتة او اكبر من
+
+390
+00:35:35,500 --> 00:35:40,380
+سيجما تلاتة او اكبر من سيجما تلاتة اومعناته حيكون
+
+391
+00:35:40,380 --> 00:35:43,720
+عندى two normal stress component sigma a و sigma b
+
+392
+00:35:43,720 --> 00:35:47,980
+يا اما التانتين حيكون موجبات sigma a و sigma b
+
+393
+00:35:47,980 --> 00:35:55,400
+موجبات او sigma a موجبة و sigma b سالبة او الحالة
+
+394
+00:35:55,400 --> 00:35:58,640
+التالتة التانية سالبة sigma a سالبة و sigma b
+
+395
+00:35:58,640 --> 00:36:03,560
+سالبة يعني عندى three cases اذا كانت sigma a و
+
+396
+00:36:03,560 --> 00:36:09,430
+sigma b positiveمعناته هيكون ان دي sigma a أكبر
+
+397
+00:36:09,430 --> 00:36:11,570
+السواء و sigma b أكبر السواء و 0 معناته هذه كأنها
+
+398
+00:36:11,570 --> 00:36:15,030
+sigma 1 وهذه sigma 2 وهذه sigma 3 معناة sigma 1
+
+399
+00:36:15,030 --> 00:36:19,290
+هتكون تساوي sigma a sigma 2 sigma b و sigma 3 صفر
+
+400
+00:36:19,290 --> 00:36:24,010
+الحالة التانية اللي هندرسها ان واحدة موجة و واحدة
+
+401
+00:36:24,010 --> 00:36:28,680
+سالفة يعني هتكون حالتي بترتيب تصعديهذه sigma a
+
+402
+00:36:28,680 --> 00:36:32,320
+موجة بقى أكبر أوي ساوة صفر وصفر أكبر أوي ساوة
+
+403
+00:36:32,320 --> 00:36:35,980
+sigma b معناته sigma واحد اللي هي sigma a و sigma
+
+404
+00:36:35,980 --> 00:36:39,540
+اتنين اللي هي صفر و sigma تلت اللي هي sigma b
+
+405
+00:36:39,540 --> 00:36:44,180
+الحالة التالتة التنين sigma a و sigma b سوالب
+
+406
+00:36:44,180 --> 00:36:48,160
+معناته هكون صفر أكبر أوي ساوة sigma a و sigma a
+
+407
+00:36:48,160 --> 00:36:50,000
+أكبر أوي ساوة sigma b
+
+408
+00:36:57,730 --> 00:37:06,830
+ب هنوضح كل حالة على حدة graphically احنا
+
+409
+00:37:06,830 --> 00:37:15,750
+عندنا three cases case one اللي
+
+410
+00:37:15,750 --> 00:37:23,990
+هي sigma a اكبر او يساوي sigma b اكبر او يساوي
+
+411
+00:37:23,990 --> 00:37:33,360
+zero هذه case oneمعناته هكون دي sigma 1 بالساوية
+
+412
+00:37:33,360 --> 00:37:40,400
+sigma a و sigma 2 بالساوية sigma b و sigma 3
+
+413
+00:37:40,400 --> 00:37:45,000
+بالساوية 0 معناته ال tau max مش الساوية بس هو
+
+414
+00:37:45,000 --> 00:37:52,320
+sigma 1 minus sigma 3 على 2 هتساوي اللي هي sigma a
+
+415
+00:37:52,320 --> 00:37:55,220
+على 2
+
+416
+00:37:58,110 --> 00:38:00,950
+According to maximum scarcity theory بيصير yield
+
+417
+00:38:00,950 --> 00:38:06,190
+again دي او بيصير failure لما tau maximum تكون
+
+418
+00:38:06,190 --> 00:38:09,290
+اكبر او يساوي as y على 2
+
+419
+00:38:14,760 --> 00:38:20,560
+أكبر أو يساوي SY على 2 يعني Sigma A أكبر أو يساوي
+
+420
+00:38:20,560 --> 00:38:25,780
+SY at this point إذا Sigma A كانت تساوية أو أكبر
+
+421
+00:38:25,780 --> 00:38:29,240
+من ال yield strength بيصير عندي failure هذه الحالة
+
+422
+00:38:29,240 --> 00:38:34,580
+الأولى عند ال load line عند هنا هي Sigma A
+
+423
+00:38:37,440 --> 00:38:43,020
+وعندي هنا هي sigma B الحلقة الأولى sigma A أكبر من
+
+424
+00:38:43,020 --> 00:38:45,120
+sigma B أكبر من sigma A يعني sigma A ال load line
+
+425
+00:38:45,120 --> 00:38:55,640
+هيكون بالشكل هذا هذه
+
+426
+00:38:55,640 --> 00:39:07,420
+sigma A وهذه sigma B الآن إذا كنا هناهيبدأ يصير
+
+427
+00:39:07,420 --> 00:39:11,240
+yielding اذا كنا هنا كنا الحدود يعني كانت زي ما
+
+428
+00:39:11,240 --> 00:39:15,740
+حكينا sigma a بيستوى sy في الحالة هذي sigma a
+
+429
+00:39:15,740 --> 00:39:19,680
+بيستوى sy بيصير اندي failure بقى انتوا هذا failure
+
+430
+00:39:19,680 --> 00:39:23,140
+line طالما
+
+431
+00:39:23,140 --> 00:39:30,640
+اندي هنا هنا في هذا الخط عندي sigma a اكبر من
+
+432
+00:39:30,640 --> 00:39:35,020
+sigma b لان لو load line تاني كان عندى
+
+433
+00:39:38,970 --> 00:39:43,610
+جاي بالشكل هذا هذه
+
+434
+00:39:43,610 --> 00:39:55,130
+هتكون sigma a وهي
+
+435
+00:39:55,130 --> 00:40:01,770
+ال actual learning conditions sigma a وهي sigma b
+
+436
+00:40:01,770 --> 00:40:05,170
+لاحظوا ال slope هذا ال critical طبعا
+
+437
+00:40:09,290 --> 00:40:18,150
+هن ال slope ايش يساوي؟ واحد في الحالة هذه هن
+
+438
+00:40:18,150 --> 00:40:29,510
+الخط هذا sigma a بيساوي sigma b هن sigma b أكبر من
+
+439
+00:40:29,510 --> 00:40:36,650
+sigma a معناته بيصير فالية عن النقطة هذهلما بيصير
+
+440
+00:40:36,650 --> 00:40:43,370
+failure لما سجمة بيه هنا لما
+
+441
+00:40:43,370 --> 00:40:47,010
+سجمة بيه بيستوى أسوأي بيبدأ يصير عندي failure على
+
+442
+00:40:47,010 --> 00:40:56,210
+الخط هذا لما سجمة a بيستوى أسوأي هنا failure when
+
+443
+00:40:56,210 --> 00:41:03,290
+سجمة a أكبر أو يستوى أسوأي هنا عندي failure
+
+444
+00:41:06,950 --> 00:41:24,390
+when sigma B أكبر أو يساوي S Y هذه
+
+445
+00:41:24,390 --> 00:41:28,530
+الحالة الأولى الحالة التانية case 2
+
+446
+00:41:39,690 --> 00:41:48,050
+سيجما A موجبة أكبر أوي سواء صفر و سيجما B سالبة في
+
+447
+00:41:48,050 --> 00:41:53,350
+الحالة هذه ستكون سواء سيجما واحد هذه سيجما اتنين
+
+448
+00:41:53,350 --> 00:42:01,420
+هذه سيجما تلاتة معناته هتكون التكون سواء سجن واحد
+
+449
+00:42:01,420 --> 00:42:06,020
+معينة سجن تلاتة على اتنين بتساوي اللي هي سجن A
+
+450
+00:42:06,020 --> 00:42:13,280
+معينة سجن B على اتنين بيصير failure at failure او
+
+451
+00:42:13,280 --> 00:42:18,240
+نحكي at failure هكون
+
+452
+00:42:18,240 --> 00:42:23,840
+عندي ال tau max بيسوء أسوأ ايه على اتنين يعني هكون
+
+453
+00:42:23,840 --> 00:42:31,240
+عندي اللي هي سجن Aminus sigma b على اتنين بتساوي
+
+454
+00:42:31,240 --> 00:42:37,760
+as y على اتنين يعني هيكون عندى sigma a minus sigma
+
+455
+00:42:37,760 --> 00:42:44,820
+b بساوي as y وضبط الطرفين ب minus minus plus minus
+
+456
+00:42:44,820 --> 00:42:53,220
+بيصير عندى sigma b بساوي sigma a minus as y
+
+457
+00:43:03,410 --> 00:43:08,210
+سيجما ايه انا حكيت موجبة سيجما بي سالب يعني انا في
+
+458
+00:43:08,210 --> 00:43:11,130
+الرابع التاني في الرابع الرابع هيكون هاي ال
+
+459
+00:43:11,130 --> 00:43:22,210
+loading line هذه سيجما ايه وهذه سيجما بيه exactly
+
+460
+00:43:22,210 --> 00:43:27,970
+at failure اذا كان اذا كان سيجما ايه at this point
+
+461
+00:43:27,970 --> 00:43:31,350
+at this point بيصير عندي failure
+
+462
+00:43:36,470 --> 00:43:44,370
+بصير عندي ايش؟ failure في
+
+463
+00:43:44,370 --> 00:43:50,830
+الحالة هذه الخط او
+
+464
+00:43:50,830 --> 00:43:53,130
+معادة الخط المستقيم هذا
+
+465
+00:44:05,750 --> 00:44:09,130
+النقطة هذه الـ fill point تمثل تقاط الخط المستقيم
+
+466
+00:44:09,130 --> 00:44:15,150
+مع الخط المستقيم هذا معادة
+
+467
+00:44:15,150 --> 00:44:23,690
+الخط هذه عندنا لو أخدت نقطة هنا سي و صفر فهي صفر و
+
+468
+00:44:23,690 --> 00:44:30,010
+minus sy وهي
+
+469
+00:44:30,010 --> 00:44:34,110
+عندنا ال strength at any location في الحالة هذه
+
+470
+00:44:34,110 --> 00:44:35,030
+السينا دي sigma b
+
+471
+00:44:38,110 --> 00:44:49,150
+بس او sigma a minus sy ال
+
+472
+00:44:49,150 --> 00:44:54,250
+case التالتة ان both sigma a و sigma b are
+
+473
+00:44:54,250 --> 00:44:57,750
+negative both sigma a و sigma b negative يعني
+
+474
+00:44:57,750 --> 00:45:01,390
+هتكون هي sigma a بهذا الاتجاه و sigma b بهذا
+
+475
+00:45:01,390 --> 00:45:05,750
+الاتجاه معناته اذا كان عندي case تلاتة
+
+476
+00:45:12,250 --> 00:45:19,210
+سفر أكبر أو يساوي سيجما A أكبر أو يساوي سيجما B
+
+477
+00:45:19,210 --> 00:45:25,450
+معناته هذا مثل سيجما واحد هذا سيجما اتنين وهذا ايش
+
+478
+00:45:25,450 --> 00:45:32,750
+سيجما تلاتة معناته tau maximum بتساوي سيجما واحد
+
+479
+00:45:32,750 --> 00:45:38,510
+minus سيجما تلاتة على اتنين بتساوي سيجما واحد سفر
+
+480
+00:45:38,510 --> 00:45:41,010
+minus سيجما
+
+481
+00:45:45,310 --> 00:45:55,630
+بي على اتنين at failure هكون
+
+482
+00:45:55,630 --> 00:46:03,270
+عندي تاو ماكس بيساوي as y على اتنين اللي هو هكون
+
+483
+00:46:03,270 --> 00:46:09,650
+عندي تاو ماكس مبرع ماينوسيجما بي على اتنين يعني at
+
+484
+00:46:09,650 --> 00:46:11,710
+failure يعني هكون اكبر او يساوي
+
+485
+00:46:18,280 --> 00:46:27,380
+SY على اتنين اذا بدى اطلب الطرفين بال .. بال minus
+
+486
+00:46:27,380 --> 00:46:33,540
+يعني حسينا دي ال sigma بيصير اصغر او يبدو اصغر او
+
+487
+00:46:33,540 --> 00:46:40,640
+يساوي minus SY معناته في الحالة هذه case three
+
+488
+00:46:45,450 --> 00:46:52,930
+يعني هذه case one case two case three الان ممكن
+
+489
+00:46:52,930 --> 00:47:01,750
+يعني في different cases الان ال failure profile من
+
+490
+00:47:01,750 --> 00:47:07,370
+Campbell جوا
+
+491
+00:47:07,370 --> 00:47:14,480
+الشكل هذا ال part is safeع الحدود أو برا ال part
+
+492
+00:47:14,480 --> 00:47:18,060
+is failing according to maximum shear stress
+
+493
+00:47:18,060 --> 00:47:18,420
+theory
+
+494
+00:47:43,940 --> 00:47:53,600
+عندي هنا plot سجم واحد على س وي سجم اتنين على س وي
+
+495
+00:47:53,600 --> 00:48:01,300
+وهذا ال contour lines اللي يتمثل ال failure طبقا ل
+
+496
+00:48:01,300 --> 00:48:04,500
+maximum shear stress theory وعندي هنا مبينة
+
+497
+00:48:04,500 --> 00:48:11,780
+experimental data بتلاحظوا ان ال theory fits ال
+
+498
+00:48:11,780 --> 00:48:17,050
+experimentaldata أحسن من ال maximum number of
+
+499
+00:48:17,050 --> 00:48:18,970
+students you received سواء في الرُبع الأول أو في
+
+500
+00:48:18,970 --> 00:48:24,450
+الرُبع الرابع لاحظوا لو أخدت loading line معين في
+
+501
+00:48:24,450 --> 00:48:31,550
+الرُبع الأول طبق
+
+502
+00:48:31,550 --> 00:48:40,170
+للنظرية طبق للنظرية we predict failure before the
+
+503
+00:48:40,170 --> 00:48:43,800
+part is actually failedwe predict failure before
+
+504
+00:48:43,800 --> 00:48:48,200
+the part is actually failed يعني نتوقع الانهيار لل
+
+505
+00:48:48,200 --> 00:48:52,920
+mechanical element قبل ما في الحقيقة انه ايش صارله
+
+506
+00:48:52,920 --> 00:48:57,040
+انهيار او failure هذا
+
+507
+00:48:57,040 --> 00:49:02,060
+يعني ان maximum shear stress theory is a
+
+508
+00:49:02,060 --> 00:49:07,540
+conservative theory يعنيانا بتوقع ال failure لسه
+
+509
+00:49:07,540 --> 00:49:11,360
+لكن في الحقيقة ماصارش failure معناته انا ال risk
+
+510
+00:49:11,360 --> 00:49:15,100
+في الحسابات بتاعتى مافيش عندى risk في الحسابات لأن
+
+511
+00:49:15,100 --> 00:49:19,580
+انا بحكي انه failed و هو في الواقع not failed
+
+512
+00:49:19,580 --> 00:49:25,320
+فمعناته it is conservative طبعا في فرق بين
+
+513
+00:49:25,320 --> 00:49:30,580
+conservative و accurate كل ما بتزيدي الدقة بشكل
+
+514
+00:49:30,580 --> 00:49:37,790
+عامبزيد عنصر المخاطرة في الحسابات يعني بتقل ال
+
+515
+00:49:37,790 --> 00:49:42,050
+conservatism ف the theory is conservative it
+
+516
+00:49:42,050 --> 00:49:46,570
+predicts failure before actually failure happens
+
+517
+00:49:48,860 --> 00:49:52,620
+نفس الشي هين او اخد load line هين هاي .. هاي ال
+
+518
+00:49:52,620 --> 00:49:57,700
+actual failure ال theory predicts failure before
+
+519
+00:49:57,700 --> 00:50:02,000
+failure actually happens معناته ال maximum share
+
+520
+00:50:02,000 --> 00:50:05,600
+of students theory is a conservative theory في كل
+
+521
+00:50:05,600 --> 00:50:13,420
+الأربعة في all the quadrants طيب
+
+522
+00:50:17,430 --> 00:50:22,390
+المحاضرة الجاي هنحكي على ال distortion energy
+
+523
+00:50:22,390 --> 00:50:27,170
+theories و بعدين هنحل أمثلة متعددة على ال maximum
+
+524
+00:50:27,170 --> 00:50:30,410
+shear stress theory و ال distortion energy theory
+
diff --git a/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/5N-tCP9cvEg.srt b/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/5N-tCP9cvEg.srt
new file mode 100644
index 0000000000000000000000000000000000000000..112434997e95372e23b11e575a891cdfa546cb77
--- /dev/null
+++ b/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/5N-tCP9cvEg.srt
@@ -0,0 +1,1493 @@
+1
+00:00:04,890 --> 00:00:07,490
+بسم الله الرحمن الرحيم السلام عليكم ورحمة الله
+
+2
+00:00:07,490 --> 00:00:12,670
+المحاضرة التي فاتت، احنا بدأنا اللي هو ال fatigue
+
+3
+00:00:12,670 --> 00:00:16,230
+design for variable loading أو fatigue failure for
+
+4
+00:00:16,230 --> 00:00:21,310
+variable loading. حكينا، اتعرفنا على ال S-N diagram
+
+5
+00:00:21,310 --> 00:00:26,090
+عملنا
+
+6
+00:00:26,090 --> 00:00:28,990
+definitions أو تعريفات لل endurance limit. حكينا ال
+
+7
+00:00:28,990 --> 00:00:31,710
+endurance limit هي ال stress level below which
+
+8
+00:00:48,600 --> 00:00:53,800
+طيب، في عندي حالات لأن ال software أنا بحكي على
+
+9
+00:00:53,800 --> 00:01:01,680
+mechanical part. بدور ومقطع مدور، بدور ومقطع مدور
+
+10
+00:01:01,680 --> 00:01:09,240
+طيب، في حالتين أو أكثر ممكن يكون المقطع مش مدور و
+
+11
+00:01:09,240 --> 00:01:15,460
+بدور، أو المقطع
+
+12
+00:01:15,460 --> 00:01:23,950
+مدور، بدور، أو المقطع مش مدور وبدور، يعني عندي ثلاث
+
+13
+00:01:23,950 --> 00:01:38,450
+احتمالات، أنه يعني ال part is واحد rotating و
+
+14
+00:01:38,450 --> 00:01:45,130
+round. هذا خلصنا منها. حالة ثانية rotating
+
+15
+00:01:49,820 --> 00:01:58,000
+and not round. مش مدور. الحالة
+
+16
+00:01:58,000 --> 00:02:08,600
+الثالثة not rotating و
+
+17
+00:02:08,600 --> 00:02:14,180
+مدور. الحالة
+
+18
+00:02:14,180 --> 00:02:24,890
+الرابعة اللي هي not rotating و
+
+19
+00:02:24,890 --> 00:02:33,050
+not round. الآن
+
+20
+00:02:33,050 --> 00:02:37,790
+الحالة الثانية
+
+21
+00:02:37,790 --> 00:02:44,870
+والثالثة والرابعة، هدول في الحالة هذه بدي
+
+22
+00:02:44,870 --> 00:02:45,790
+أوجد equivalent
+
+23
+00:02:54,700 --> 00:03:02,060
+round and rotating specimen
+
+24
+00:03:02,060 --> 00:03:14,720
+or part. الآن
+
+25
+00:03:14,720 --> 00:03:19,840
+ال equivalent round and rotating specimen is found
+
+26
+00:03:19,840 --> 00:03:24,180
+based on this principle: ال volume of material
+
+27
+00:03:24,180 --> 00:03:31,280
+stressed at and above 5% of maximum stress. يعني لو
+
+28
+00:03:31,280 --> 00:03:39,960
+عندي شيء under، بدور ومدور، هي مدور و
+
+29
+00:03:39,960 --> 00:03:49,540
+بدور لأن ال stress distribution هيكون بالشكل هذا
+
+30
+00:04:05,610 --> 00:04:11,350
+هذا ال stress distribution بأخذ
+
+31
+00:04:11,350 --> 00:04:14,650
+ال mechanical part وبأخذ الجزء الأخير، الحلقة
+
+32
+00:04:14,650 --> 00:04:15,790
+الأخيرة
+
+33
+00:04:33,120 --> 00:04:42,580
+عند هذه ال maximum stress، هذا sigma maximum بأخذ
+
+34
+00:04:42,580 --> 00:04:52,560
+عند location بيتمثل 95% من sigma maximum، بتكون ال
+
+35
+00:04:52,560 --> 00:04:53,580
+area هذه تقريباً
+
+36
+00:05:17,520 --> 00:05:26,440
+ال volume بتاع الحلقة هذه، بأسوي له same volume in
+
+37
+00:05:26,440 --> 00:05:36,480
+rotating beam specimen. طبعاً هذا non rotating، بأسوي
+
+38
+00:05:36,480 --> 00:05:42,960
+ال volume هذا لـ same volume في حالة rotating beam
+
+39
+00:05:42,960 --> 00:05:43,780
+specimen
+
+40
+00:05:46,880 --> 00:05:51,320
+الآن، لو العينة طولها متر، وال mechanical part
+
+41
+00:05:51,320 --> 00:05:55,180
+الحقيقة طوله متر، المتر مع متر بلغة بيظل معناته
+
+42
+00:05:55,180 --> 00:06:01,260
+اللي هي الـ a ninety five، الـ a point nine five
+
+43
+00:06:01,260 --> 00:06:08,860
+sigma. مش هخش في تفاصيل اشتقاق تاعها الآن. a point
+
+44
+00:06:08,860 --> 00:06:15,050
+ninety five for a rotating، for a rotating round
+
+45
+00:06:15,050 --> 00:06:21,350
+specimen.  مطابقة العلاقة هذه بـ point 0.766D تربيع
+
+46
+00:06:21,350 --> 00:06:27,290
+الآن لو أخذت non
+
+47
+00:06:27,290 --> 00:06:31,730
+rotating round، هتكون تسمع non rotating round
+
+48
+00:06:31,730 --> 00:06:34,730
+هتكون الـ a point nine nine point nine five sigma
+
+49
+00:06:34,730 --> 00:06:45,110
+بـ point 0.146. لو سويت هذه اللي هي point 0.146
+
+50
+00:06:45,110 --> 00:06:52,030
+D2، سويتها للمعادلة السابقة اللي
+
+51
+00:06:52,030 --> 00:07:00,050
+هتكون point 0.766 D equivalent دي تربيع. هو إن
+
+52
+00:07:00,050 --> 00:07:06,390
+أنا بحسب ال D equivalent في
+
+53
+00:07:06,390 --> 00:07:12,000
+الحالة، ال D equivalent هتطلع بـ point 0.37 D في
+
+54
+00:07:12,000 --> 00:07:19,200
+حالة.
+
+55
+00:07:19,200 --> 00:07:27,060
+في حالة مقطع مستطيل، يعني مش مدور أو بدور، هتكون ال A
+
+56
+00:07:27,060 --> 00:07:31,680
+point nine five بـ point 0.5H في B.  في حالة مقطع
+
+57
+00:07:31,680 --> 00:07:36,560
+مستطيل، اللي
+
+58
+00:07:36,560 --> 00:07:49,160
+هي B، بتكون الـ a point 95 بـ point 0.5H في B. هذه
+
+59
+00:07:49,160 --> 00:07:55,320
+هأسويها للـ a point 95 لـ
+
+60
+00:07:55,320 --> 00:08:00,340
+rotating round، specifically point 0.766 دي
+
+61
+00:08:00,340 --> 00:08:03,080
+equivalent. ومن هنا بحسب الـ d equivalent، تطلع
+
+62
+00:08:03,080 --> 00:08:06,900
+المعادلة هذه point 0.88HB  نص
+
+63
+00:08:10,050 --> 00:08:15,970
+table ستة تلاتة بيعطينا، بيعطينا الـ a point تسعة
+
+64
+00:08:15,970 --> 00:08:21,330
+خمسة sigma، والـ D equivalent لـ different cross
+
+65
+00:08:21,330 --> 00:08:25,670
+sections. يعني ال cross section ده مدور، ومنه بحسب
+
+66
+00:08:25,670 --> 00:08:27,970
+الـ D equivalent بـ 0.37 D. هذا
+
+67
+00:08:27,970 --> 00:08:32,450
+المقطع مستطيل B في H، ومنه بحسب الـ D equivalent بـ
+
+68
+00:08:32,450 --> 00:08:37,090
+0.88 تربيعي لـ H في B
+
+69
+00:08:37,090 --> 00:08:39,110
+طبعاً في مقاطع ثانية
+
+70
+00:08:42,310 --> 00:08:47,370
+لو كان عندي I beam، الـ a point تسعة خمسة بتختلف
+
+71
+00:08:47,370 --> 00:08:52,250
+بحسب المحور ال axis، ال axis واحد واحد، بتكون ال A
+
+72
+00:08:52,250 --> 00:08:57,910
+point nine five اللي هي point 0.1 ATF، ال A
+
+73
+00:08:57,910 --> 00:09:06,690
+اللي هي هذه A، هذه B، و TF اللي هي هذه وهذه
+
+74
+00:09:06,690 --> 00:09:13,740
+axis اتنين اتنين. هذا axis 1 1، إذا ال axis 1 1 بتكون
+
+75
+00:09:13,740 --> 00:09:19,440
+الـ a.95 بيساوي 0.1 ATF. إذا ال axis 2 2 بتكون ال a
+
+76
+00:09:19,440 --> 00:09:27,860
+.95 بيساوي 0.5B في A. في حالة ال channel، طبعاً هذا
+
+77
+00:09:27,860 --> 00:09:35,160
+ال axis 1 1، وهذا ال axis 2 2. هذا B
+
+78
+00:09:40,140 --> 00:09:45,640
+وهذه A. الـ a point nine five لـ axis واحد واحد
+
+79
+00:09:45,640 --> 00:09:49,500
+بتساوي point 0.5AB. والـ a point nine five
+
+80
+00:09:49,500 --> 00:09:54,080
+بتساوي point 0.52X في A زائد point 0.1
+
+81
+00:09:54,080 --> 00:09:56,620
+TF في B ناقص X، X اللي هي هذه المسافة
+
+82
+00:10:11,690 --> 00:10:15,450
+طبعاً دائماً بحصل equivalent round and rotating
+
+83
+00:10:15,450 --> 00:10:22,270
+specimen، في حالة أنه كان ال mechanical parts is
+
+84
+00:10:22,270 --> 00:10:26,590
+rotating and not round، أو كان not rotating and
+
+85
+00:10:26,590 --> 00:10:33,110
+round، أو كان not rotating and not round. شوف
+
+86
+00:10:33,110 --> 00:10:33,550
+مثال
+
+87
+00:10:55,050 --> 00:10:59,290
+A steel shaft loaded in bending. عندي عمود مصنوع من
+
+88
+00:10:59,290 --> 00:11:03,590
+الحديد. ال loading عليه bending، is 32 mm in
+
+89
+00:11:03,590 --> 00:11:07,130
+diameter، abutting a filleted shoulder 38 mm in
+
+90
+00:11:07,130 --> 00:11:11,810
+diameter. يعني أنا عندي shaft جاي زي هيك
+
+91
+00:11:39,450 --> 00:11:49,830
+هذا القطر 32 مليمتر، مسلم
+
+92
+00:11:49,830 --> 00:11:58,970
+القطر أكبر 38 مليمتر
+
+93
+00:11:58,970 --> 00:11:59,370
+ميتراً
+
+94
+00:12:02,990 --> 00:12:06,550
+The shaft material has a mean ultimate the shaft
+
+95
+00:12:06,550 --> 00:12:09,290
+material has a mean ultimate tensile strength of
+
+96
+00:12:09,290 --> 00:12:17,650
+690 MPa. يعني ال Sut بيساوي 690 ميجاباسكال
+
+97
+00:12:17,650 --> 00:12:22,150
+estimate
+
+98
+00:12:22,150 --> 00:12:27,870
+the size factor Kb if the shaft is used in a
+
+99
+00:12:27,870 --> 00:12:28,630
+rotating mode
+
+100
+00:12:34,640 --> 00:12:44,000
+if shaft is rotating، معناته
+
+101
+00:12:44,000 --> 00:12:53,620
+إذا ال shaft is rotating، ال
+
+102
+00:12:53,620 --> 00:13:00,060
+Kb في الحالة هذه، ال
+
+103
+00:13:00,060 --> 00:13:00,480
+Kb
+
+104
+00:13:05,010 --> 00:13:09,550
+لحظة، القطر اللي عندك هيكون 32، ال 32 هتكون
+
+105
+00:13:09,550 --> 00:13:13,610
+المعادلة هذه، اللي هو هتكون Kb هتكون بـ واحد
+
+106
+00:13:13,610 --> 00:13:20,430
+point 1.24D أس نص ناقص point 0.107
+
+107
+00:13:20,430 --> 00:13:26,630
+هتساوي 1.24 في D اللي هي 32
+
+108
+00:13:26,630 --> 00:13:31,010
+أس نص ناقص 0.107
+
+109
+00:13:35,360 --> 00:13:43,740
+هتكون 32 أس نص ناقص 0.107
+
+110
+00:13:43,740 --> 00:13:51,900
+هتكون في 1.24، هتطلع 0.856. هذا
+
+111
+00:13:51,900 --> 00:13:58,880
+في حالة ال shaft is rotating. طيب، إذا ال shaft is
+
+112
+00:13:58,880 --> 00:14:05,770
+not rotating. if shaft is
+
+113
+00:14:05,770 --> 00:14:15,210
+not rotating، معناته مطلوب مني أحسب equivalent
+
+114
+00:14:15,210 --> 00:14:22,610
+round rotating specimen. يعني هستخدم المعادلة
+
+115
+00:14:22,610 --> 00:14:28,270
+اللي هي De، دي equivalent هتساوي
+
+116
+00:14:32,200 --> 00:14:39,300
+0.37D. هتساوي 0.37 في
+
+117
+00:14:39,300 --> 00:14:48,040
+32. هيطلع
+
+118
+00:14:48,040 --> 00:14:57,300
+عندي
+
+119
+00:14:57,300 --> 00:14:57,680
+11.84
+
+120
+00:15:00,840 --> 00:15:12,100
+11.84 مليمتر. once عرفت ال equivalent
+
+121
+00:15:12,100 --> 00:15:23,570
+diameter، بحسب ال Kb هتساوي 1.24 دي equivalent ناقص 0.
+
+122
+00:15:23,570 --> 00:15:32,770
+107
+
+123
+00:15:32,770 --> 00:15:35,050
+ناقص 0.107
+
+124
+00:15:46,010 --> 00:15:53,450
+ناقص 0.107 × 1.24.  Kb هتكون 0.952
+
+125
+00:16:11,000 --> 00:16:14,400
+نأتي ل modification factor الثالث اللي هو ال
+
+126
+00:16:14,400 --> 00:16:30,020
+loading factor Kc، ال
+
+127
+00:16:30,020 --> 00:16:35,340
+loading factor Kc بياخذ في عين الاعتبار التغيرات
+
+128
+00:16:35,340 --> 00:16:38,920
+في ال endurance limit الناتجة عن تغيير نوع ال
+
+129
+00:16:38,920 --> 00:16:44,380
+loading. احنا حكينا ال standard fatigue specimen
+
+130
+00:16:44,380 --> 00:16:50,220
+بيكون لـ completely reverse bending load. لكن على
+
+131
+00:16:50,220 --> 00:16:56,570
+أرض الواقع يمكن تكون ال load axial load، ممكن torsion
+
+132
+00:16:56,570 --> 00:17:01,490
+ال load، ممكن bending، ممكن transverse shear load
+
+133
+00:17:01,490 --> 00:17:05,910
+ممكن أي combination. المعادلة اللي هتشوفوها اللي
+
+134
+00:17:05,910 --> 00:17:12,370
+هي الآن معادلة 6-26، نستخدمها في حالة single load
+
+135
+00:17:12,370 --> 00:17:18,910
+type. يعني بيكون القطعة الميكانيكية متعرضة لنوع محدد
+
+136
+00:17:18,910 --> 00:17:25,450
+أو نوع واحد من التحميل. ممكن يكون ال load axial أو
+
+137
+00:17:25,450 --> 00:17:28,090
+bending أو torsion
+
+138
+00:17:29,980 --> 00:17:32,620
+في الحالة دي بس، بأخذ المعادلة هذه. إذا كان bending هو
+
+139
+00:17:32,620 --> 00:17:35,360
+أساساً ال standard bending، معناته ال Kc هيكون
+
+140
+00:17:35,360 --> 00:17:39,740
+بواحد. إذا كان axial، Kc بيساوي 0.85. إذا كان ال
+
+141
+00:17:39,740 --> 00:17:43,320
+torsion، Kc بيساوي 0.59. لكن إذا كان عندي
+
+142
+00:17:43,320 --> 00:17:46,960
+combination of loading، يعني كان خلطة عندي axial مع
+
+143
+00:17:46,960 --> 00:17:51,360
+... مع ... مع bending مع torsion، نستخدم ما يسمى
+
+144
+00:17:51,360 --> 00:17:54,200
+الطريقة اللي هي combination loading method اللي هي
+
+145
+00:17:54,200 --> 00:18:00,050
+مشروحة في section 6-14 في Shigley. معناته المعادلة هذه
+
+146
+00:18:00,050 --> 00:18:08,310
+applies for single load types. ال
+
+147
+00:18:08,310 --> 00:18:12,350
+modification factor الرابع اللي هو اللي بياخذ في
+
+148
+00:18:12,350 --> 00:18:16,870
+الاعتبار التغير بدرجة الحرارة، لأن الفحص المياري
+
+149
+00:18:16,870 --> 00:18:25,750
+بيصير عند درجة حرارة الغرفة. الآن لما القطعة تسخن
+
+150
+00:18:25,750 --> 00:18:31,830
+تتغير ال tensile strength بتاعتها. الآن في ال table
+
+151
+00:18:31,830 --> 00:18:41,190
+6-4، المرجح ال ratio ل for steel، طبعاً لل tensile
+
+152
+00:18:41,190 --> 00:18:45,980
+strength، the temperature under study على ال tensile
+
+153
+00:18:45,980 --> 00:18:49,960
+strength at room temperature. هنا درجة الحرارة، هنا
+
+154
+00:18:49,960 --> 00:18:54,380
+ال ratio بين ال St على SRT، ال St هي ال tensile
+
+155
+00:18:54,380 --> 00:18:58,140
+strength at ال operating temperature، والـ SRT هي
+
+156
+00:18:58,140 --> 00:19:06,760
+ال tensile strength at room temperature. الآن
+
+157
+00:19:06,760 --> 00:19:15,010
+عشان أحسب ال Kd، في عندي أكثر من حالة. if ultimate
+
+158
+00:19:15,010 --> 00:19:17,710
+strength is known for the operating temperature
+
+159
+00:19:17,710 --> 00:19:24,190
+يعني ال St معروف. يعني واحد واحد
+
+160
+00:19:24,190 --> 00:19:33,490
+if ال St at T is known
+
+161
+00:19:37,160 --> 00:19:44,480
+بعدين بحكي Se' بيساوي نص ال St، وبحط كده بيساوي
+
+162
+00:19:44,480 --> 00:19:59,280
+واحد. هاي حالة. حالة ثانية، ال St، ال SRT is known، اللي
+
+163
+00:19:59,280 --> 00:20:02,040
+هي ال strength at room temperature is known
+
+164
+00:20:05,820 --> 00:20:11,220
+بروح على table 6
+
+165
+00:20:11,220 --> 00:20:18,580
+-4 اللي هو هذا ال table و
+
+166
+00:20:18,580 --> 00:20:30,260
+بطلع منه St على S room temperature، ومنه بحسب ال
+
+167
+00:20:30,260 --> 00:20:37,220
+St. بعدين بحكي Se' بيساوي نص ال St، وفي الحالة هذه
+
+168
+00:20:37,220 --> 00:20:49,060
+برضه بحط Kd بيساوي واحد. حالة ثالثة، ال
+
+169
+00:20:49,060 --> 00:20:55,100
+الـ الـ strength at room temperature الـ
+
+170
+00:20:55,100 --> 00:20:59,700
+SRT is known
+
+171
+00:21:03,090 --> 00:21:09,350
+منه بحسب Se' بيساوي نص الـ S room
+
+172
+00:21:09,350 --> 00:21:18,670
+temperature. بعدين من table 6-4 بحسب ال Kd بيساوي
+
+173
+00:21:18,670 --> 00:21:23,690
+St على S room temperature. بعدين بعمل modification
+
+174
+00:21:23,690 --> 00:21:27,390
+Se بيساوي Kd في Se'
+
+175
+00:21:37,160 --> 00:21:42,700
+البيانات اللي في جدول 6-4 معمول لها
+
+176
+00:21:42,700 --> 00:21:51,480
+curve fit من خلال polynomial من الدرجة الرابعة. ال
+
+177
+00:21:51,480 --> 00:21:56,120
+Kd is a function of temperature، والتمبريتشر معبر
+
+178
+00:21:56,120 --> 00:22:00,420
+عنها بوحدة الفهرنهايت. ال Kd is given by this
+
+179
+00:22:00,420 --> 00:22:04,640
+equation بيساوي 0.975 زائد 0.0432 في 10
+
+180
+00:22:04,640 --> 00:22:09,520
+أس 3 TF ناقص 0.115 في 10 أس 5 TF تربيع
+
+181
+00:22:09,520 --> 00:22:14,840
+ناقص 0.104 في 10 أس ناقص 8 في TF تكعيب ناقص
+
+182
+00:22:14,840 --> 00:22:20,480
+0.595 في 10 أس ناقص 12 TF أس 4. لاحظوا إن TF
+
+183
+00:22:20,480 --> 00:22:22,660
+معبر عنها بوحدة الفهرنهايت
+
+184
+00:22:28,560 --> 00:22:43,040
+نشوف مثال. a
+
+185
+00:22:43,040 --> 00:22:50,040
+1035 steel. عندي حديد اللي هو 1035
+
+186
+00:22:50,040 --> 00:22:55,280
+steel. هذه ال material has a tensile strength
+
+187
+00:22:59,2
+
+223
+00:26:39,970 --> 00:26:40,190
+ثلاثين Pound تسعة ثلاثين Pound تسعة ثلاثين Pound
+
+224
+00:26:40,190 --> 00:26:48,650
+تسعة ثلاثين Pound تسعة ثلاثين Pound تسعة
+
+225
+00:26:48,650 --> 00:26:54,490
+ثلاثين Pound
+
+226
+00:26:58,750 --> 00:27:01,070
+only the tensile strength at room temperature اللي
+
+227
+00:27:01,070 --> 00:27:07,790
+هي هذه is given يعني only as room temperature is
+
+228
+00:27:07,790 --> 00:27:15,370
+known يعني
+
+229
+00:27:15,370 --> 00:27:21,960
+ممكن أعمل التالي أروح على ال table six أربعة وأحسب
+
+230
+00:27:21,960 --> 00:27:27,780
+ST على S رومتين ريتشار زي ما حسبنا تطلع واحد point
+
+231
+00:27:27,780 --> 00:27:35,480
+O O ستة خمسة واحسب ST بس واحد point O O ستة خمسة في
+
+232
+00:27:35,480 --> 00:27:39,620
+اللي هي سبعين
+
+233
+00:27:49,760 --> 00:27:54,900
+تطلع سبعين point أربعة خمسة
+
+234
+00:27:54,900 --> 00:28:00,760
+خمسة kilo pound per square inch و هحكي SE عند أربع
+
+235
+00:28:00,760 --> 00:28:10,120
+مية و خمسين سواء نص ال ST يعني هتكون نص في سبعين
+
+236
+00:28:10,120 --> 00:28:19,120
+point أربعة خمسة خمسة فنص هتكون
+
+237
+00:28:20,790 --> 00:28:34,290
+خمسة و ثلاثين Pound أو
+
+238
+00:28:34,290 --> 00:28:43,660
+احتياجي بتستوي كدي يعني or SE Prime سواء نص ال SU
+
+239
+00:28:43,660 --> 00:28:49,200
+T اللي هي نص في سبعين عند room temperature بتساوي
+
+240
+00:28:49,200 --> 00:28:53,520
+خمسة و ثلاثين kilo pound per square inch بعدين أحكي S
+
+241
+00:28:53,520 --> 00:29:02,020
+E SE عند الأربع مية و خمسين بتساوي ال KD في ال S
+
+242
+00:29:02,020 --> 00:29:09,020
+E Prime عند السبعين ال
+
+243
+00:29:09,020 --> 00:29:15,470
+KD اللي بيساوي ST على S room temperature اللي
+
+244
+00:29:15,470 --> 00:29:34,950
+بيساوي 1.0065 هتكون معناته واحدة 1.0065 في 35 تطلع
+
+245
+00:29:34,950 --> 00:29:37,370
+نفس ال issue 32
+
+246
+00:29:40,500 --> 00:29:45,500
+أو خمسة و ثلاثين point اتنين اتنين سبعة خمسة kilo
+
+247
+00:29:45,500 --> 00:30:02,060
+pound per square inch بصراحة نفس النتيجة ال
+
+248
+00:30:02,060 --> 00:30:04,640
+modification factor الخامس اللي هو reliability
+
+249
+00:30:04,640 --> 00:30:06,960
+factor reliability factor
+
+250
+00:30:19,090 --> 00:30:26,510
+نرجع لشكل 6.17 شكل 6.17 كان عامل plot بين ال
+
+251
+00:30:26,510 --> 00:30:33,890
+tensile strength Sut و ال SE prime و كانت ال
+
+252
+00:30:33,890 --> 00:30:39,650
+relation linear في النص for
+
+253
+00:30:43,780 --> 00:30:46,600
+الخط في المصدر يمثل خمسين في المئة reliability of
+
+254
+00:30:46,600 --> 00:30:52,380
+data يعني نسبة النجاح أن .. نسبة النجاح أن الخط
+
+255
+00:30:52,380 --> 00:30:56,940
+هذا يمثل ال experimental data خمسين في المئة يعني
+
+256
+00:30:56,940 --> 00:30:59,580
+خمسين في المئة من البيانات above خمسين في المئة من
+
+257
+00:30:59,580 --> 00:31:01,400
+البيانات and below
+
+258
+00:31:06,930 --> 00:31:10,070
+يعني اللي أنا لو حكيت reliability تسعين في المئة
+
+259
+00:31:10,070 --> 00:31:13,650
+معناته نسبة النجاح أن ال line to fit the data is
+
+260
+00:31:13,650 --> 00:31:16,310
+تسعين في المئة نسبة النجاح تكون تسعين في المئة لما
+
+261
+00:31:16,310 --> 00:31:19,950
+نحكي reliability عبارة ال reliability عادة تعرف
+
+262
+00:31:19,950 --> 00:31:27,550
+واحد minus احتمالية ال failure فلو نحكي
+
+263
+00:31:27,550 --> 00:31:31,950
+reliability تسعين في المئة معناته في احتمال أن ال
+
+264
+00:31:31,950 --> 00:31:38,690
+data يكون تمثيله للبيانات بنسبة خطأ عشرة في المئة
+
+265
+00:31:38,690 --> 00:31:44,590
+فمعناته النجاح عندي تسعين في المئة فال SE prime
+
+266
+00:31:44,590 --> 00:31:56,170
+بيساوي نص SUT is based on fifty percent
+
+267
+00:31:56,170 --> 00:32:01,990
+reliability of experimental data
+
+268
+00:32:04,660 --> 00:32:09,760
+إذا بدي more reliable fit معناته محتاج أعمل
+
+269
+00:32:09,760 --> 00:32:22,220
+modification لل SE prime ال KE موضوع في ال table 6
+
+270
+00:32:22,220 --> 00:32:29,600
+5 ال table 6 5 إذا كان reliability لل fitting لل
+
+271
+00:32:29,600 --> 00:32:32,440
+experimental data 50% معناته مش modification نفس
+
+272
+00:32:32,440 --> 00:32:37,710
+اللي احنا عملنا واحد ال 90% بيبقى 8 9 7 و هكذا كل
+
+273
+00:32:37,710 --> 00:32:44,610
+ما كانت أنا محتاج نسبة أعلى لتمثيل ال experimental
+
+274
+00:32:44,610 --> 00:32:50,050
+data كل ما أنا محتاج أنزل اللي هي ال endurance
+
+275
+00:32:50,050 --> 00:32:54,510
+limit ومعناته ال KE بتقل بارتفاع قيمة
+
+276
+00:32:54,510 --> 00:32:54,990
+reliability
+
+277
+00:33:00,790 --> 00:33:05,610
+ال factor الأخير اللي هو miscellaneous effects factor
+
+278
+00:33:05,610 --> 00:33:10,030
+اللي هو factor بحط كذا شغلات .. كذا شغلة مع بعض
+
+279
+00:33:10,030 --> 00:33:16,550
+يعني شغلات غير منظورة مثلاً ممكن ال mechanical part
+
+280
+00:33:16,550 --> 00:33:20,850
+متعرض لبيئة .. بيئة very corrosive يعني زي بيئة
+
+281
+00:33:20,850 --> 00:33:26,930
+البحر بتعمل صدأ و تأكل سريع أو محطوط مثلاً معمول
+
+282
+00:33:26,930 --> 00:33:33,620
+تقسي سطحية لل mechanical part أو مطلب مادة ثانية
+
+283
+00:33:33,620 --> 00:33:38,980
+مطلب كروم أو مطلب ب .. ب .. ب zinc أو في صارت عليه
+
+284
+00:33:38,980 --> 00:33:43,100
+عمليات .. عمليات ميكانيكية مثلاً عمليات تشكيل
+
+285
+00:33:43,100 --> 00:33:49,380
+عمليات تشكيل بتخلي المادة فيها
+
+286
+00:33:49,380 --> 00:33:52,760
+stresses أو صار عملية عملية الحنفة فيه stresses
+
+287
+00:33:52,760 --> 00:33:58,430
+هذه كلها different effects لازم نأخذها بالاعتبار
+
+288
+00:33:58,430 --> 00:34:03,290
+طبعاً مافيش حاجة محددة تعتمد على المصمم هو يتخذ قرار
+
+289
+00:34:03,290 --> 00:34:08,590
+يقدّر ال factor تاع ال miscellaneous effects ممكن
+
+290
+00:34:08,590 --> 00:34:13,010
+إذا بده شغل أدق يعمل عليها more research or
+
+291
+00:34:13,010 --> 00:34:20,590
+testing معناته
+
+292
+00:34:20,590 --> 00:34:25,640
+إحنا نرجع لمعادلة الأصلية لنا SE ال Modified Endurance
+
+293
+00:34:25,640 --> 00:34:30,020
+Limit بيستوي ل KA, KB, KC, KD, KE, KF, SE Prime
+
+294
+00:34:30,020 --> 00:34:33,680
+SE Prime هي ال Endurance Limit ل Standard
+
+295
+00:34:33,680 --> 00:34:37,840
+Fatigue Specimen That Is Highly Polished That Is
+
+296
+00:34:37,840 --> 00:34:44,040
+Under Completely Reversed Bending وشرحنا إيش هو
+
+297
+00:34:44,040 --> 00:34:47,760
+ال KA، إيش هو ال KB و KC و KD و KE و KF و KFA
+
+298
+00:34:47,760 --> 00:34:50,720
+قلنا حساب كل factor على حدة
+
+299
+00:34:53,340 --> 00:34:56,800
+الآن إذا بيصير عندي الآن النقطة اللي هندرسها
+
+300
+00:34:56,800 --> 00:34:59,520
+إضافية الآن اللي هي ال stress concentration and
+
+301
+00:34:59,520 --> 00:35:03,720
+notch sensitivity يعني stress concentration مثلاً
+
+302
+00:35:03,720 --> 00:35:11,860
+لو أنا صار عندي تغير مفاجئ في القطر تغير
+
+303
+00:35:11,860 --> 00:35:15,440
+مفاجئ بيصير عندي هنا في المنطقة هذه stress
+
+304
+00:35:15,440 --> 00:35:21,020
+concentration أو
+
+305
+00:35:21,020 --> 00:35:26,680
+مثلاً عندي plate و فيه ثقب عند ال hole عند ال hole
+
+306
+00:35:26,680 --> 00:35:31,680
+هي مباشرة بيكون ال stress is maximum بيعلى ال
+
+307
+00:35:31,680 --> 00:35:35,900
+stress من نتيجة تركيز الإجهاد إحنا درسنا في
+
+308
+00:35:35,900 --> 00:35:41,560
+chapter ثلاثة حكينا في appendix A15 بيعطي ال
+
+309
+00:35:41,560 --> 00:35:44,040
+geometric stress concentration factor KT في
+
+310
+00:35:44,040 --> 00:35:48,020
+appendix A15 لأن إحنا عندنا fatigue loading يعني ال
+
+311
+00:35:48,020 --> 00:35:51,820
+loading is variable معناته محتاج fatigue stress
+
+312
+00:35:51,820 --> 00:35:55,320
+concentration factor ال fatigue stress
+
+313
+00:35:55,320 --> 00:36:00,940
+concentration factor KF  معطى
+
+314
+00:36:00,940 --> 00:36:07,760
+العلاقة واحد زائد Q في KT ناقص واحد أو ممكن أحكي Q
+
+315
+00:36:07,760 --> 00:36:10,980
+باسم KF ناقص واحد على KT ناقص واحد في حالة اللي
+
+316
+00:36:10,980 --> 00:36:15,580
+هو ال normal stress في حالة shear stress باسم KF
+
+317
+00:36:15,580 --> 00:36:20,570
+S ناقص واحد على KT S ناقص واحد ال KFS اللي هو
+
+318
+00:36:20,570 --> 00:36:25,410
+shear fatigue stress concentration factor ال KTS
+
+319
+00:36:25,410 --> 00:36:28,830
+اللي هي shear geometric stress concentration
+
+320
+00:36:28,830 --> 00:36:33,470
+factor و ال Q notch sensitivity بيعبر عن مدى
+
+321
+00:36:33,470 --> 00:36:41,700
+حساسية المادة للخدوش إذا كانت ال Q صفر معناته ال
+
+322
+00:36:41,700 --> 00:36:45,720
+material مش حساسة للخدوش في الحالة هذه ال K في ال
+
+323
+00:36:45,720 --> 00:36:49,100
+KF بيساوي واحد يعني إذا ال material كانت very
+
+324
+00:36:49,100 --> 00:36:54,880
+ductile مش هتكون حساسة للخدوش إذا كانت ال Q واحد
+
+325
+00:36:54,880 --> 00:36:59,500
+يعني fully sensitive هتكون ال KF بيساوي KT زي
+
+326
+00:36:59,500 --> 00:37:03,840
+المواد الهشة أو ال very hard بتكون حساسة للخدوش
+
+327
+00:37:08,660 --> 00:37:12,240
+الآن ال notch sensitivity factor بيعتمد على نوع ال
+
+328
+00:37:12,240 --> 00:37:17,010
+loading إذا كان ال loading bending and axial بحسب
+
+329
+00:37:17,010 --> 00:37:22,870
+ال Q من figure 6.20 figure 6.20 على المحور الأفقي ..
+
+330
+00:37:22,870 --> 00:37:28,170
+الأفقي معطيني ال notch radius notch radius are هنا
+
+331
+00:37:28,170 --> 00:37:31,210
+بواحدة ال inch وهنا بواحدة ال millimeter يعني هنا
+
+332
+00:37:31,210 --> 00:37:34,590
+عنده نص واحد millimeter واحد و نص اتنين اتنين و نص
+
+333
+00:37:34,590 --> 00:37:37,710
+ثلاثة ثلاثة و نص أربعة هنا بواحدة ال inch point o
+
+334
+00:37:37,710 --> 00:37:40,530
+two point o four يعني هذا ال axis هو نفس ال axis
+
+335
+00:37:40,530 --> 00:37:43,850
+بس هذا metric unit هذا English unit على المحور
+
+336
+00:37:43,850 --> 00:37:50,640
+الرأسي معطيني ال Q وعندي different curves هذا ال
+
+337
+00:37:50,640 --> 00:37:55,800
+curve ل steel ال tensile strength بتاعته 200 kilo
+
+338
+00:37:55,800 --> 00:37:59,620
+pound per square inch الكيرف هذا ل steel ال
+
+339
+00:37:59,620 --> 00:38:02,580
+tensile strength بتاعته 150 kilo pound per square
+
+340
+00:38:02,580 --> 00:38:06,120
+inch الكيرف الثالث ل steel ال tensile strength
+
+341
+00:38:06,120 --> 00:38:09,880
+بتاعته 100 كيرف هذا ل steel ال tensile strength
+
+342
+00:38:09,880 --> 00:38:15,060
+بتاعته 60 الكيرف ال dotted للألمنيوم في الحالة دي
+
+343
+00:38:15,060 --> 00:38:19,380
+KF بيساوي واحد زائد Q في KT ناقص واحد
+
+344
+00:38:23,770 --> 00:38:29,500
+الشكل 6.21 معطيني ال notch sensitivity for torsional
+
+345
+00:38:29,500 --> 00:38:31,920
+loading نفس الأشياء على المحور الأفقي عندي ال notch
+
+346
+00:38:31,920 --> 00:38:36,640
+radius بالإنش أو ال notch radius بالمليمتر هنا ال
+
+347
+00:38:36,640 --> 00:38:41,540
+QS ال notch sensitivity for shear وهنا معطيني ال S
+
+348
+00:38:41,540 --> 00:38:48,060
+ال tensile strength هنا عندي 200 هنا عندي 150 160
+
+349
+00:38:48,060 --> 00:38:53,700
+وهذا الألمونيوم و ال KFS بيساوي واحد زائد QS في
+
+350
+00:38:53,700 --> 00:38:55,420
+KTS ناقص واحد
+
+351
+00:39:00,510 --> 00:39:07,630
+يعني يا إما بنستخدم figure 6.20 أو figure 6.21 أو بنعمل
+
+352
+00:39:07,630 --> 00:39:13,730
+curve fit equations للأشكال 6.20 و 6.21 في الحالة
+
+353
+00:39:13,730 --> 00:39:19,010
+هذه بحسب ال Q بيساوي واحد على واحد زائد جذر A على
+
+354
+00:39:19,010 --> 00:39:23,170
+جذر R و ال KF بيساوي واحد زائد KT ناقص واحد على واحد زائد جذر
+
+355
+00:39:23,170 --> 00:39:28,940
+A على R لأن جذر A في حالة bending أو axial loading معطى
+
+356
+00:39:28,940 --> 00:39:32,960
+العلاقة هذه it is a function of tensile strength
+
+357
+00:39:32,960 --> 00:39:37,380
+في حالة torsional loading جذر A معطى العلاقة هذه
+
+358
+00:39:37,380 --> 00:39:40,940
+يعني أنت مخيّر يا إما تستخدم figure ستة وعشرين
+
+359
+00:39:40,940 --> 00:39:45,480
+figure ستة و عشرين وواحد وعشرين أو بتستخدم المعادلات اللي
+
+360
+00:39:45,480 --> 00:39:49,400
+هي معادلة 6.34 6.36 ومعادلة هذه
+
+361
+00:39:49,400 --> 00:39:55,800
+و معادلة هذه لحساب اللي هو ال ال KF
+
+362
+00:40:03,400 --> 00:40:10,580
+الآن في حالة حديد السكب ال cast iron ال cast iron
+
+363
+00:40:10,580 --> 00:40:17,220
+already مليء بالخدوش وبالتالي لما نعمل له فحص الشد
+
+364
+00:40:17,220 --> 00:40:21,220
+لل cast iron بيكون already فيه خدوش وعاملين يعني it
+
+365
+00:40:21,220 --> 00:40:24,980
+is taking care of اللي هو اللي هو ال notches
+
+366
+00:40:26,300 --> 00:40:29,840
+وبالتالي إذا هو عنده عدد كبير جداً جداً من ال
+
+367
+00:40:29,840 --> 00:40:33,620
+notches إذا أضفت one notch أو two notches مش هتفرق
+
+368
+00:40:33,620 --> 00:40:37,900
+معاه it is recommended أن نستخدم في حالة ال cast
+
+369
+00:40:37,900 --> 00:40:46,860
+iron  للكي يبساط one to four cast irons نشوف
+
+370
+00:40:46,860 --> 00:40:48,320
+example 6.6
+
+371
+00:40:53,930 --> 00:40:58,070
+استيل شافت عمود من الحديد in bending نوع ال
+
+372
+00:40:58,070 --> 00:41:03,670
+loading bending has an ultimate strength ال SUT
+
+373
+00:41:03,670 --> 00:41:07,870
+بيساوي
+
+374
+00:41:07,870 --> 00:41:13,950
+ستمئة و تسعين ميجا باسكال and
+
+375
+00:41:13,950 --> 00:41:15,910
+a shoulder with a fillet radius of three
+
+376
+00:41:15,910 --> 00:41:18,550
+millimeter connecting a thirty two millimeter with
+
+377
+00:41:18,550 --> 00:41:20,590
+a thirty eight millimeter diameter يعني دي هي
+
+378
+00:41:20,590 --> 00:41:33,970
+القطعة القطر 32 ملم قطر 38 32
+
+379
+00:41:33,970 --> 00:41:50,150
+ملم قطر على
+
+380
+00:41:50,150 --> 00:41:50,710
+الشرط
+
+381
+00:41:54,420 --> 00:42:00,620
+هذا اثنين و ثلاثين ملم
+
+382
+00:42:00,620 --> 00:42:08,540
+متصل بثلاثين ملم و
+
+383
+00:42:08,540 --> 00:42:17,900
+الفيلت ال radius بتاعها ثلاثة ملم دوران
+
+384
+00:42:17,900 --> 00:42:25,550
+estimate KF using figure 6.20 أولاً نحسب KF
+
+385
+00:42:25,550 --> 00:42:38,450
+باستخدام figure 6.20 فنروح على figure 6.20 figure
+
+386
+00:42:38,450 --> 00:42:42,530
+6.20 معطيني ال notch الفيلت عندي 3 ملم 3 ملم هاي 3
+
+387
+00:42:42,530 --> 00:42:46,910
+ملم 3
+
+388
+00:42:46,910 --> 00:42:48,010
+ملم هاي 3 ملم
+
+389
+00:42:56,950 --> 00:43:05,750
+طيب ال SUT 690 ميجا عندها 1.4 جيجا يعني 1400 ميجا
+
+390
+00:43:05,750 --> 00:43:11,890
+هنا 1000 ميجا هنا 700 ميجا و هنا يعني جاية تقريباً
+
+391
+00:43:11,890 --> 00:43:21,910
+جاية هنا يعني تحت شوية من ال 700 ميجا تقريباً
+
+392
+00:43:21,910 --> 00:43:23,170
+لو أمد
+
+393
+00:43:32,840 --> 00:43:41,740
+يعني تقريباً هتطلع ال Q هذه point يعني
+
+394
+00:43:41,740 --> 00:43:47,660
+تقريباً ربع المسافة هذه مثلاً point 2 ربع point 2
+
+395
+00:43:47,660 --> 00:43:53,100
+point 1 point .. point Q هتكون سواء point 8 خمسة
+
+396
+00:43:53,100 --> 00:44:02,720
+Q بيساوي point 8 خمسة طيب ال KF بيساوي واحد زائد Q
+
+397
+00:44:02,720 --> 00:44:09,760
+في KT ناقص واحد إحنا لحدّ الآن حسبنا Q بيساوي point
+
+398
+00:44:09,760 --> 00:44:16,060
+ثمانية خمسة طيب بدي أحسب ال KT إحنا عندنا bending
+
+399
+00:44:16,060 --> 00:44:19,900
+بدي
+
+400
+00:44:19,900 --> 00:44:23,100
+أحسب ال KT ال KT بيقدروا يروحوا على appendix A خمسة
+
+401
+00:44:23,100 --> 00:44:26,960
+عشر أروح على appendix A خمسة عشر
+
+402
+00:44:35,070 --> 00:44:43,890
+في كتاب شكل A15 اللي هو هذا اللي
+
+403
+00:44:43,890 --> 00:44:51,470
+مش الحالة هذه ولا هذه هتكون
+
+404
+00:44:51,470 --> 00:44:56,310
+A15 9  خانات أكبر عليها A15 9
+
+405
+00:45:08,030 --> 00:45:18,83
+
+445
+00:50:04,460 --> 00:50:10,960
+حصل نفس النتيجة، جرّبه عوضه في المعدلات وطلع الـ Q و
+
+446
+00:50:10,960 --> 00:50:20,760
+طلع الـ KF حتى حصل نفس النتيجة تقريباً، طيب
+
+447
+00:50:34,230 --> 00:50:40,390
+طيب، المحاضرة الجاية سنكمل application of fatigue
+
+448
+00:50:40,390 --> 00:50:42,430
+stress concentration factor
diff --git a/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/A-1SThU8Qv4.srt b/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/A-1SThU8Qv4.srt
new file mode 100644
index 0000000000000000000000000000000000000000..c978c600fd8ca9d807734db3034ce9473478bb10
--- /dev/null
+++ b/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/A-1SThU8Qv4.srt
@@ -0,0 +1,1286 @@
+1
+00:00:05,090 --> 00:00:09,710
+السلام عليكم اليوم هنكمل chapter أربعة أو
+
+2
+00:00:09,710 --> 00:00:14,490
+deflection and stiffness of beams في المحاضرة التي
+
+3
+00:00:14,490 --> 00:00:17,930
+الفاتة تعرفنا على elasticity  التي هي خاصية للمادة
+
+4
+00:00:17,930 --> 00:00:23,030
+تمكّنها من استعادة شكلها بمجرد رفع الأحمال
+
+5
+00:00:23,030 --> 00:00:26,030
+spring  جايبها عن mechanical element الذي لو
+
+6
+00:00:26,030 --> 00:00:27,870
+عملت له deflection يعطيني force
+
+7
+00:00:30,960 --> 00:00:34,700
+ال spring rate الذي هو  K  يساوي ΔF على
+
+8
+00:00:34,700 --> 00:00:40,540
+ΔY في حالة linear spring  ال K يساوي F على Y عرفنا
+
+9
+00:00:40,540 --> 00:00:44,280
+ال spring أو we derive the spring constant ل X
+
+10
+00:00:44,280 --> 00:00:49,000
+reloaded member كان ال K يساوي A × E على L ×
+
+11
+00:00:49,000 --> 00:00:53,400
+حالة torsion reloaded member كان عنده ال stiffness
+
+12
+00:00:53,400 --> 00:00:57,360
+constant أو ال stiffness rate K يساوي G J على
+
+13
+00:00:57,360 --> 00:00:58,140
+L
+
+14
+00:01:01,070 --> 00:01:04,410
+بعدين درسنا deflection due to bending in straight
+
+15
+00:01:04,410 --> 00:01:10,550
+beams وصلنا إلى علاقة أن bending moment M على EI
+
+16
+00:01:10,550 --> 00:01:15,930
+يساوي D²Y/DX² باستخدام العلاقة هذه ممكن إيجاد
+
+17
+00:01:15,930 --> 00:01:22,370
+slope أو deflection at any point along the
+
+18
+00:01:22,370 --> 00:01:30,150
+beam as a function of X  حلينا two examples  جِئنا به
+
+19
+00:01:30,150 --> 00:01:34,690
+ال deflection و ال slopes at any location for a
+
+20
+00:01:34,690 --> 00:01:40,450
+beam عليه distributed load باستخدام المعادلة التي هي
+
+21
+00:01:40,450 --> 00:01:46,410
+M على EI يساوي D²Y/DX² بعد حكينا فيه أكثر من
+
+22
+00:01:46,410 --> 00:01:50,550
+طريقة لحسابات ال deflection منها superposition
+
+23
+00:01:50,550 --> 00:01:55,710
+ال numerical integration و ال Castellano method بدأنا في
+
+24
+00:01:55,710 --> 00:01:59,190
+ال superposition ال superposition تحكي ببساطة أن
+
+25
+00:01:59,190 --> 00:02:03,870
+ال total effect due to the combined loading
+
+26
+00:02:03,870 --> 00:02:09,670
+condition يساوي مجموع ال individual effect due to
+
+27
+00:02:09,670 --> 00:02:14,070
+individual loading conditions طبعاً  عشان نحل
+
+28
+00:02:14,070 --> 00:02:18,550
+superposition سنستخدم table A9 في الكتاب حلينا
+
+29
+00:02:18,550 --> 00:02:22,430
+example الأربعة، اثنين باستخدام ال superposition
+
+30
+00:02:26,090 --> 00:02:29,990
+سنحل المسألة الثانية باستخدام ال support position
+
+31
+00:02:29,990 --> 00:02:36,930
+سنحل المسألة التالية determine the deflection
+
+32
+00:02:36,930 --> 00:02:40,230
+equations using support position for the given
+
+33
+00:02:40,230 --> 00:02:47,480
+beam في عندي beam simply supported عند a و b وطائر
+
+34
+00:02:47,480 --> 00:02:52,680
+من B إلى C فيه  أثر distributed load بين A
+
+35
+00:02:52,680 --> 00:02:59,300
+و B وفيه concentrated load عند طرف الطائر C  معناته
+
+36
+00:02:59,300 --> 00:03:06,060
+هنا عندي support عندي
+
+37
+00:03:06,060 --> 00:03:06,880
+hand support
+
+38
+00:03:13,250 --> 00:03:16,210
+نحسب ال reactions و ال deflections due to this
+
+39
+00:03:16,210 --> 00:03:23,110
+loading condition باستخدام ال superposition أنا
+
+40
+00:03:23,110 --> 00:03:28,750
+المثال هذا عشان أحله لازم أجزئه بحيث أستخدم
+
+41
+00:03:28,750 --> 00:03:33,650
+الجداول في appendix A9  يعني المثال كله ممكن أقول
+
+42
+00:03:33,650 --> 00:03:38,030
+التالي: أنا عندي هذه ال total condition
+
+43
+00:03:49,330 --> 00:03:57,050
+عندي هنا distributed
+
+44
+00:03:57,050 --> 00:04:07,870
+load W وعندي هنا total load F هذا ما كنا نحكيه
+
+45
+00:04:07,870 --> 00:04:11,690
+أنه عبارة هذا ال total effect عبارة عن مجموع two
+
+46
+00:04:11,690 --> 00:04:13,590
+effects  الأول
+
+47
+00:04:24,080 --> 00:04:34,440
+عبارة عن distributed load زائد
+
+48
+00:04:34,440 --> 00:04:37,980
+concentrated
+
+49
+00:04:37,980 --> 00:04:38,620
+load
+
+50
+00:04:55,340 --> 00:05:00,800
+F معناته هذا ال total effect عندي distributed load
+
+51
+00:05:00,800 --> 00:05:05,420
+وعندي concentrated load هذا عبارة عن مجموع ال two
+
+52
+00:05:05,420 --> 00:05:10,920
+effects ال effect due to concentrated load W و ال
+
+53
+00:05:10,920 --> 00:05:15,160
+effect due to concentrated load F طبعاً سيكون عندي
+
+54
+00:05:15,160 --> 00:05:18,940
+due
+
+55
+00:05:18,940 --> 00:05:28,890
+to this سيكون عندي هنا R1' وهنا R2'
+
+56
+00:05:30,230 --> 00:05:35,990
+وهنا سيكون عندي R1W'
+
+57
+00:05:36,610 --> 00:05:40,510
+وهنا R2W'
+
+58
+00:05:41,210 --> 00:05:47,890
+وفي عندي أيضاً هنا Y' due to this deflection و YW'
+
+59
+00:05:48,410 --> 00:05:50,090
+due to this deflection
+
+60
+00:05:55,670 --> 00:06:04,310
+معناته سآخذ two conditions الحالة
+
+61
+00:06:04,310 --> 00:06:09,150
+الأولى، الحالة الأولى عبارة عن distributed load
+
+62
+00:06:37,290 --> 00:06:52,830
+و الحالة الثانية عبارة عن concentrated load F
+
+63
+00:06:52,830 --> 00:07:05,750
+هنا عندي R1 prime و R2 prime هنا عندي R1 double
+
+64
+00:07:05,750 --> 00:07:13,930
+prime وهنا عندي R2 double prime أريد
+
+65
+00:07:13,930 --> 00:07:17,770
+أن أشوف loading condition الموجودة في ال table تشبه هذه
+
+66
+00:07:17,770 --> 00:07:20,050
+الحالة، و loading condition الموجودة في ال table
+
+67
+00:07:20,050 --> 00:07:25,090
+مكافئة لهذه الحالة لما
+
+68
+00:07:25,090 --> 00:07:29,030
+بالنسبة للحالة الأولى هذه ستكون الحالة المكافئة
+
+69
+00:07:29,030 --> 00:07:31,470
+التي هي A
+
+70
+00:07:33,510 --> 00:07:38,570
+تسعة سبعة، آية سبعة، الآية هذه، لكن يختلف أنني
+
+71
+00:07:38,570 --> 00:07:44,210
+عندي F فيه زيادة هنا، يعني سيكون عندي إيش فيه
+
+72
+00:07:44,210 --> 00:07:50,310
+زيادة طول هذا هو ال deflected beam
+
+73
+00:07:50,310 --> 00:07:56,250
+R واحد ال prime ستكون
+
+74
+00:07:56,250 --> 00:08:06,060
+يساوي، كما ترون، يساوي R2' يساوي
+
+75
+00:08:06,060 --> 00:08:15,820
+WL ... أريد التأكد من التسمية الثانية هنا WL على
+
+76
+00:08:15,820 --> 00:08:25,540
+اثنين هذه ... هذه بالمناسبة هذه ... هذه L وهذه ماذا؟
+
+77
+00:08:25,540 --> 00:08:25,860
+A
+
+78
+00:08:32,630 --> 00:08:39,350
+ال و ماذا؟
+
+79
+00:08:39,350 --> 00:08:49,950
+ال و ماذا؟ ونفس الشيء عندي هنا
+
+80
+00:08:49,950 --> 00:08:56,490
+ال و ماذا؟ وهنا
+
+81
+00:08:56,490 --> 00:08:58,070
+ال و ماذا؟
+
+82
+00:09:02,500 --> 00:09:05,360
+و ال deflection من النقطة هذه، هذه النقطة، is given by
+
+83
+00:09:05,360 --> 00:09:14,880
+this equation  Y' لهذه الحالة Y' ستساوي
+
+84
+00:09:14,880 --> 00:09:23,300
+التي هي WX على
+
+85
+00:09:23,300 --> 00:09:30,800
+24EI × (2LX² - X³)
+
+86
+00:09:36,110 --> 00:09:40,710
+ناقص L³ طبعاً هذه العلاقة X من صفر إلى L الآن
+
+87
+00:09:55,670 --> 00:09:57,110
+due to loading
+
+88
+00:10:08,660 --> 00:10:20,000
+عندي a, b, c  عندي هي a, b, c أجزاء ال beam سيكون
+
+89
+00:10:20,000 --> 00:10:26,620
+ال deflection  بتاعه عندي
+
+90
+00:10:26,620 --> 00:10:27,260
+هي a
+
+91
+00:10:37,230 --> 00:10:57,850
+A, B, C  ال deflection ستكون بالشكل هذا يعني
+
+92
+00:10:57,850 --> 00:11:01,830
+هذه المعادلة تعطينا ال deflection من A إلى B من النقطة
+
+93
+00:11:01,830 --> 00:11:04,690
+هذه إلى النقطة هذه، لأن من B إلى C
+
+94
+00:11:09,310 --> 00:11:13,930
+يعني سيبقى ال slope من B إلى C سيظل ال slope ثابتاً
+
+95
+00:11:13,930 --> 00:11:22,550
+يعني لو جئنا ب slope الذي هو Y' = dy/dx
+
+96
+00:11:22,550 --> 00:11:32,070
+Y' ستكون W على 24EI هذا بشكل عام فيه
+
+97
+00:11:36,920 --> 00:11:46,560
+سيكون ستة X² ناقص
+
+98
+00:11:46,560 --> 00:11:56,960
+أربعة X³ ناقص L³ هذا at any location بين
+
+99
+00:11:56,960 --> 00:12:03,220
+X ... بين X for X هنا بين صفر و L
+
+100
+00:12:07,210 --> 00:12:15,450
+at x = L يعني dy/dx' at x = L
+
+101
+00:12:15,450 --> 00:12:22,910
+ستكون تساوي W
+
+102
+00:12:22,910 --> 00:12:32,770
+على أربعة وعشرين EI × 6
+
+103
+00:12:32,770 --> 00:12:35,250
+L³
+
+104
+00:12:37,040 --> 00:12:47,400
+ناقص أربعة L³ ناقص L³  سيساوي
+
+105
+00:12:47,400 --> 00:12:53,860
+ستة ناقص أربعة اثنين ناقص واحد واحد سيكون W
+
+106
+00:12:53,860 --> 00:13:07,780
+L³ على أربعة وعشرين E × I هذا ال slope  الذي
+
+107
+00:13:07,780 --> 00:13:15,580
+هو هذه الزاوية θ هذا ال slope الآن هذه المسافة
+
+108
+00:13:15,580 --> 00:13:20,040
+أو
+
+109
+00:13:20,040 --> 00:13:23,720
+عند أي location عند أي location X
+
+110
+00:13:27,210 --> 00:13:31,350
+هذه المسافة ستكون ماذا؟ X  معناته هذه المسافة ستكون
+
+111
+00:13:31,350 --> 00:13:40,590
+ماذا؟ X - L at
+
+112
+00:13:40,590 --> 00:13:50,210
+X at any location X at any location at any
+
+113
+00:13:50,210 --> 00:13:52,870
+location
+
+114
+00:13:57,520 --> 00:14:06,920
+X بكل slope الذي هو tan θ الذي
+
+115
+00:14:06,920 --> 00:14:20,180
+هو عبارة عن dy/dx الذي هو هذا tan θ سيكون W
+
+116
+00:14:20,180 --> 00:14:34,070
+L³ على 24EI  يساوي ال slope سيكون الذي هو ال Y
+
+117
+00:14:34,070 --> 00:14:40,690
+على
+
+118
+00:14:40,690 --> 00:14:52,030
+X - L X - L معناته
+
+119
+00:14:52,030 --> 00:14:53,130
+Y'
+
+120
+00:14:59,250 --> 00:15:12,550
+يساوي WL³ × (X - L) على 24EI
+
+121
+00:15:12,550 --> 00:15:18,950
+طبعاً هذه عند N في المنطقة هذه، بين B و C معناته
+
+122
+00:15:25,560 --> 00:15:27,700
+ممكن أقول ال deflection due to the distributed
+
+123
+00:15:27,700 --> 00:15:36,680
+load سيكون Y', Y'
+
+124
+00:15:37,180 --> 00:15:41,120
+يساوي
+
+125
+00:15:41,120 --> 00:15:50,840
+جزئين، الجزء الأول سيكون
+
+126
+00:15:50,840 --> 00:15:54,360
+هذا، الذي هو WX
+
+127
+00:16:01,160 --> 00:16:06,180
+انتبه هنا للإشارات
+
+128
+00:16:06,180 --> 00:16:12,240
+... للإشارات، إذا عوضت مثلاً X = L/2، X = L
+
+129
+00:16:12,240 --> 00:16:17,220
+على 2 ستكون ال Y Maximum = -5WL⁴ على 384EI
+
+130
+00:16:17,220 --> 00:16:26,840
+على 2 × E × I الآن ال Y' ستكون WX على
+
+131
+00:16:26,840 --> 00:16:30,560
+24EI
+
+132
+00:16:32,400 --> 00:16:48,740
+× (2LX² - X³ - L³ )  X
+
+133
+00:16:48,740 --> 00:16:56,840
+بين صفر و L الفترة الثانية ستكون
+
+134
+00:17:01,660 --> 00:17:06,820
+ستكون تساوي WL³
+
+135
+00:17:06,820 --> 00:17:20,620
+على 24EI ×
+
+136
+00:17:20,620 --> 00:17:25,520
+(X - L)
+
+137
+00:17:25,520 --> 00:17:39,970
+طبعاً هنا X > L  و X < L + A معناته
+
+138
+00:17:39,970 --> 00:17:45,530
+we find deflection due to this loading condition
+
+139
+00:17:45,530 --> 00:17:50,670
+الذي سنأخذ الحالة الثانية، هذه الحالة
+
+140
+00:17:58,180 --> 00:18:05,200
+load أو ال beam تحت أثر قوة مركزة عند الطرف الحر
+
+141
+00:18:05,200 --> 00:18:12,440
+نرجع
+
+142
+00:18:12,440 --> 00:18:20,600
+إلى مسألتنا، أقرب
+
+143
+00:18:20,600 --> 00:18:27,060
+حالة لحالتنا التي هي appendix A
+
+144
+00:18:29,830 --> 00:18:36,890
+تسعة عشر، يعطيني
+
+145
+00:18:36,890 --> 00:18:44,890
+هنا R واحد double prime تساوي
+
+146
+00:18:44,890 --> 00:18:55,230
+FA على L و R اثنين double
+
+147
+00:18:55,230 --> 00:18:58,490
+prime تساوي
+
+148
+00:19:02,130 --> 00:19:09,290
+لكن انتبهوا للإشارات، R واحد ستكون بالسالب، أنا
+
+149
+00:19:09,290 --> 00:19:17,950
+لأنها جاية تحت، ستكون بالسالب، و R اثنين double prime F
+
+150
+00:19:17,950 --> 00:19:29,130
+على L × (L + A) بالنسبة
+
+151
+00:19:29,130 --> 00:19:36,560
+ال deflection  ال deflection عبارة عن مقطعين فيه
+
+152
+00:19:36,560 --> 00:19:41,300
+deflection معادلة من a إلى b وفيه معادلة من b إلى c
+
+153
+00:19:41,300 --> 00:19:50,620
+يعني سيكون عندي Y double prime من
+
+154
+00:19:50,620 --> 00:19:58,580
+a إلى b سيكون FAX على
+
+155
+00:19:58,580 --> 00:19:59,440
+6EI L
+
+156
+00:20:04,770 --> 00:20:10,870
+× (L² - X²) يعني
+
+157
+00:20:10,870 --> 00:20:16,610
+هنا X بين صفر و
+
+158
+00:20:16,610 --> 00:20:24,910
+L والمقطع الثاني FX - L
+
+159
+00:20:24,910 --> 00:20:31,130
+على 6EI
+
+160
+00:20:36,700 --> 00:20:50,060
+× (X - L)² ناقص
+
+161
+00:20:50,060 --> 00:21:03,810
+A × 3(X - L)  و X ≥ L  ≤ L + A معناته
+
+162
+00:21:03,810 --> 00:21:09,950
+أوجدنا ال individual effect for each loading
+
+163
+00:21:09,950 --> 00:21:12,830
+condition  أوجدنا R1 prime و R2 prime و Y prime ووجدنا
+
+164
+00:21:12,830 --> 00:21:18,810
+ال individual effect due to this loading condition
+
+165
+00:21:18,810 --> 00:21:22,270
+عندي R1 prime و R2 prime و Y W prime معناته ال total
+
+166
+00:21:22,270 --> 00:21:27,110
+effect  R1 = R1' + R1W'
+
+167
+00:21:27,110 --> 00:21:34,500
+R1'= WL/2 - FA/L R2
+
+168
+00:21:35,080 --> 00:21:49,200
+R2 = R2' + R2W'
+
+169
+00:21:49,200 --> 00:21:54,440
+WL على اثنين زائد F على L × (L + A)
+
+170
+00:21:55,400 --> 00:22:12,040
+ال total deflection ال Y يساوي
+
+171
+00:22:12,040 --> 00:22:17,020
+Y' زائد YW'  يعني ال Y ستساوي
+
+172
+00:22:26,000 --> 00:22:33,100
+المقطع الأول ال WX
+
+173
+00:22:33,100 --> 00:22:38,900
+ال WX
+
+174
+00:22:38,900 --> 00:22:54,740
+WX على 24EI × (2LX² - X³ - L³)
+
+175
+00:22:54,740 --> 00:23:11,820
+زائد FAX على 6EI L × (L² - X²)
+
+176
+00:23:11,820 --> 00:23:18,920
+طبعاً هنا X من صفر إلى L المقطع الثاني الذي هو
+
+177
+00:23:18,920 --> 00:23:22,880
+WL³
+
+178
+00:23:22,880 --> 00:23:34,590
+على 24EI × (X - L) زائد
+
+179
+00:23:34,590 --> 00:23:51,410
+F × (X - L) على 6EI × (X - L)²
+
+180
+00:23:51,410 --> 00:24:01,900
+ناقص A × 3(X - L) هنا X ≥ L  ≤ A + L معناته
+
+181
+00:24:01,900 --> 00:24:09,700
+وجدنا ال total effect وجدنا ال reactions R واحد و R اثنين و ال total
+
+182
+00:24:09,700 --> 00:24:13,300
+deflection at any location Y وto double check
+
+183
+00:24:13,300 --> 00:24:19,360
+calculation  عوض X = صفر ستعطيني ماذا؟
+
+184
+00:24:19,360 --> 00:24:27,900
+Deflection = صفر عوض X = L ستكون صفر
+
+185
+00:24:27,900 --> 00:24:33,040
+وهي صفر، معناته الشيء صحيح
+
+186
+00:25:21,630 --> 00:25:28,630
+إذا عندي زنبرك وسحبت وضغط من ال mask سيكون فيه
+
+187
+00:25:28,630 --> 00:25:32,990
+طاقة مختزنة أسميها strain energy هذه الطاقة
+
+188
+00:25:32,990 --> 00:25:37,650
+المختزنة نتيجة أنه عليه deflection لو تركت طرف
+
+189
+00:25:38,540 --> 00:25:41,900
+الزنبرك سيرجع، معناته فيه potential energy طالما
+
+190
+00:25:41,900 --> 00:25:46,200
+أنا مسكه، هي ممسوكة طالما فلاتته سيرجع الزنبرك
+
+191
+00:25:46,200 --> 00:25:50,920
+إلى حالته، معناته سيكون عندي شغل أو طاقة مختزنة
+
+192
+00:25:50,920 --> 00:25:54,860
+أسميها strain energy due to deflection إذا عند
+
+193
+00:25:54,860 --> 00:26:04,860
+زنبرك، هذا X هذا F و linear spring  عرفنا الشغل
+
+194
+00:26:04,860 --> 00:26:11,240
+عبارة عن ماذا؟ الشغل عبارة عن force × distance
+
+195
+00:26:11,240 --> 00:26
+
+223
+00:29:07,340 --> 00:29:15,500
+كان سوى GG على L  الـ K سوى GG على L الـ U نرجع
+
+224
+00:29:15,500 --> 00:29:23,000
+للمعادلة الأصلية الـ U بسوء F square على 2K
+
+225
+00:29:26,010 --> 00:29:32,390
+و الـ K في الحالة هت يعني بتساوي يعني الـ F is
+
+226
+00:29:32,390 --> 00:29:42,430
+analog للـ torque و الـ K عبارة عن GG على L يعني الـ
+
+227
+00:29:42,430 --> 00:29:47,570
+U في حالة torque in loaded member هتكون عوض عن F
+
+228
+00:29:47,570 --> 00:29:55,320
+في T على اتنين في K اللي هو G G على L يعني هتكون
+
+229
+00:29:55,320 --> 00:30:04,480
+سوى T square L على اتنين G في G هدف الحالة كان الـ
+
+230
+00:30:04,480 --> 00:30:09,560
+torque constant و المقطع constant مع الطول لو كان
+
+231
+00:30:09,560 --> 00:30:17,950
+واحد من الـ torque أو المقطع متغير مع الطول أو
+
+232
+00:30:17,950 --> 00:30:23,730
+كلاهما بيصير عند الـ U تكامل بيصير الـ U ساوى تكامل
+
+233
+00:30:23,730 --> 00:30:33,130
+T squared على اتنين GJ DX في
+
+234
+00:30:33,130 --> 00:30:38,290
+حالة direct shear loading هذا direct shear هذا
+
+235
+00:30:38,290 --> 00:30:43,440
+torsional shear في حالة direct shear loading بيكون
+
+236
+00:30:43,440 --> 00:30:46,540
+الـ strain energy due to direct shear is given by
+
+237
+00:30:46,540 --> 00:30:51,460
+this equation الـ
+
+238
+00:30:51,460 --> 00:30:55,140
+A مساحة المقطع الـ G الـ modulus of rigidity في حال
+
+239
+00:30:55,140 --> 00:30:59,000
+كانت الـ force متغيرة قيمتها أو الـ cross section
+
+240
+00:30:59,000 --> 00:31:02,720
+بتغير من مكان لمكان بيصير تتحول لمعادلة
+
+241
+00:31:02,720 --> 00:31:10,000
+integration في حال
+
+242
+00:31:10,000 --> 00:31:17,250
+bending هذا bending condition الـ .. الـ .. الـ strain
+
+243
+00:31:17,250 --> 00:31:20,770
+energy due to bending is given by this equation M
+
+244
+00:31:20,770 --> 00:31:24,130
+squared L على 2EI هذا في حالة كانت الـ bending
+
+245
+00:31:24,130 --> 00:31:29,530
+moment ثابتة مع الطول و المقطع ثابت مع الطول في
+
+246
+00:31:29,530 --> 00:31:36,540
+حالة كان المقطع متغير مع الطول أو و الـ bending moment متغير
+
+247
+00:31:36,540 --> 00:31:39,500
+مع المقطع والطول بيصير عندي list of energy is
+
+248
+00:31:39,500 --> 00:31:42,800
+given by this equation تكامل M squared على 2 EI DX
+
+249
+00:31:53,660 --> 00:31:58,260
+في حالة transverse shear loading يعني بيكون عندي
+
+250
+00:31:58,260 --> 00:32:01,760
+bending يعني عندي الـ load هنا بس بيكون shear هنا
+
+251
+00:32:01,760 --> 00:32:05,180
+يعني الـ shear متجه عند الـ load هذا بيسمى
+
+252
+00:32:05,180 --> 00:32:08,640
+transverse shear condition في الحالة ده الـ U
+
+253
+00:32:08,640 --> 00:32:15,740
+بيساوي C في V square L على 2A في G الـ V اللي هو الـ
+
+254
+00:32:15,740 --> 00:32:20,220
+shear load أو الـ transverse shear الـ L الطول الـ A
+
+255
+00:32:20,220 --> 00:32:24,900
+المقطع و الـ G الـ modulus of rigidity و الـ C
+
+256
+00:32:24,900 --> 00:32:29,820
+modifier constant بيعتمد على شكل المقطع الشكل
+
+257
+00:32:29,820 --> 00:32:34,340
+المقطع ممكن مدور مستطيل مثلث الـ C تعتمد على شكل
+
+258
+00:32:34,340 --> 00:32:35,380
+المقطع
+
+259
+00:32:43,240 --> 00:32:48,160
+جدول أربعة واحد معطيني الـ modifier factor C في
+
+260
+00:32:48,160 --> 00:32:54,690
+حالة transverse shear loading condition مقطع شكله
+
+261
+00:32:54,690 --> 00:32:58,330
+مستطيل الـ C بيكون سوى 1.2 في حالة
+
+262
+00:32:58,330 --> 00:33:02,590
+مقطع شكله مدور بتكون الـ C 2.11 في
+
+263
+00:33:02,590 --> 00:33:06,650
+حالة المقطع عبارة عن أنبوب مدورة و رفيعة بتكون الـ
+
+264
+00:33:06,650 --> 00:33:10,950
+C بيساوي 2 في حالة box section بتكون سوى الـ
+
+265
+00:33:10,950 --> 00:33:20,670
+الـ الـ الـ الـ C بيساوي 1 نشوف مثال هذا
+
+266
+00:33:20,670 --> 00:33:25,400
+المثال اللي هنحله السؤال هذا و ننهي المحاضرة إن شاء
+
+267
+00:33:25,400 --> 00:33:28,800
+الله
+
+268
+00:33:28,800 --> 00:33:45,280
+الـ
+
+269
+00:33:45,280 --> 00:33:51,000
+cantilever beam with a round cross section with
+
+270
+00:33:51,000 --> 00:33:53,920
+a round cross section الـ cantilever beam مقطعه
+
+271
+00:33:53,920 --> 00:34:01,520
+مدور مقطعه مدور has a concentrated load F at the
+
+272
+00:34:01,520 --> 00:34:07,540
+end فيه load مركز عند الطرف قيمة الـ load F
+
+273
+00:34:09,720 --> 00:34:15,800
+Find the strain energy in the beam أولا
+
+274
+00:34:15,800 --> 00:34:18,360
+عشان أحل مثل هذا لازم I have to define الـ
+
+275
+00:34:18,360 --> 00:34:25,940
+coordinate system تبعي عندي هاي الـ Y هذا
+
+276
+00:34:25,940 --> 00:34:32,300
+الـ Y هذا
+
+277
+00:34:32,300 --> 00:34:43,120
+الـ X باخد على مسافة باخد هي section على بعد X
+
+278
+00:34:43,120 --> 00:34:58,660
+و باخد free body diagram عند
+
+279
+00:34:58,660 --> 00:34:59,760
+هذه الـ force F
+
+280
+00:35:05,100 --> 00:35:13,440
+و هذه المسافة X أكيد
+
+281
+00:35:13,440 --> 00:35:21,400
+هيعكسها force F أحيانا أو خلينا نسميها V هتعمل
+
+282
+00:35:21,400 --> 00:35:28,640
+counter clockwise moment هتعكسها clockwise moment
+
+283
+00:35:28,640 --> 00:35:31,840
+و هي
+
+284
+00:35:31,840 --> 00:35:44,400
+عند الـ X و هاي الـ Y اللي
+
+285
+00:35:44,400 --> 00:35:51,300
+أخد summation of forces  بتجاه
+
+286
+00:35:51,300 --> 00:36:00,490
+الـ Y  بالساوية صفر هيكون عندي minus F زائد V يعني الـ
+
+287
+00:36:00,490 --> 00:36:12,570
+V هتساوي إيه؟ F أخذت
+
+288
+00:36:12,570 --> 00:36:18,450
+الـ .. الـ .. الـ moment هين summation of moment
+
+289
+00:36:18,450 --> 00:36:29,840
+حول نقطة X بالساوية صفر هيكون minus F في X زائد
+
+290
+00:36:29,840 --> 00:36:40,780
+M يعني الـ M هتساوي عندي إيه؟ F في X طيب
+
+291
+00:36:40,780 --> 00:36:46,640
+اللحظة و أنا عندي at any cross section at any
+
+292
+00:36:46,640 --> 00:36:51,140
+cross
+
+293
+00:36:51,140 --> 00:36:51,600
+section
+
+294
+00:36:55,670 --> 00:37:00,210
+we have bending
+
+295
+00:37:00,210 --> 00:37:04,790
+moment
+
+296
+00:37:04,790 --> 00:37:09,210
+and
+
+297
+00:37:09,210 --> 00:37:13,610
+transverse
+
+298
+00:37:13,610 --> 00:37:18,410
+shear معناته
+
+299
+00:37:18,410 --> 00:37:23,310
+total strain energy الـ U هتكون U U to transverse
+
+300
+00:37:23,310 --> 00:37:33,650
+shear the due due to bending moment نرجع
+
+301
+00:37:33,650 --> 00:37:49,430
+للمعادلات due
+
+302
+00:37:49,430 --> 00:37:51,130
+to bending moment you
+
+303
+00:37:54,880 --> 00:38:04,860
+due to bending moment المعادلة هذه بتساوي تكامل M تربيع
+
+304
+00:38:04,860 --> 00:38:11,400
+على 2 EI DX
+
+305
+00:38:11,400 --> 00:38:19,300
+حيث ساوى طبعا التكامل من 0 لـ L هيكون تكامل من 0
+
+306
+00:38:19,300 --> 00:38:26,470
+لـ L الـ M هيبقى عبارة عن F X أحسب أن عندي F تربيع X
+
+307
+00:38:26,470 --> 00:38:35,050
+تربيع على 2 EI DX لاحظوا أن المقطع ثابت و الـ force
+
+308
+00:38:35,050 --> 00:38:37,370
+ثابتة هيطلع عبارة عن الـ integration هيكون الساوي
+
+309
+00:38:37,370 --> 00:38:48,450
+F تربيع على 2EI تكامل X
+
+310
+00:38:48,450 --> 00:38:56,200
+تربيع DX من صفر لـ L يعني إذا بعملها تكامل هتكون F تربيع
+
+311
+00:38:56,200 --> 00:39:06,600
+على 2EI لـ X تكعيب على 3 من صفر لـ L يعني هتكون
+
+312
+00:39:06,600 --> 00:39:17,960
+تساوي F تربيع L تكعيب على 6EI
+
+313
+00:39:22,040 --> 00:39:27,940
+الآن المقطع المدور الـ I للمقطع المدور الـ I للمقطع
+
+314
+00:39:27,940 --> 00:39:33,680
+المدور عبارة عن باي على أربعة و ستين D أس أربعة
+
+315
+00:39:33,680 --> 00:39:38,240
+يعني
+
+316
+00:39:38,240 --> 00:39:47,900
+هتصير الـ U to bending moment هتكون تساوي F
+
+317
+00:39:47,900 --> 00:39:57,450
+تربيع L تكعيب على ستة E في I اللي هي باي على أربعة
+
+318
+00:39:57,450 --> 00:40:06,730
+ستين D أس أربعة هتساوي
+
+319
+00:40:06,730 --> 00:40:11,150
+2
+
+320
+00:40:11,150 --> 00:40:18,230
+و 30 F تربيع L تكعيب
+
+321
+00:40:21,780 --> 00:40:32,780
+على 3 E باي D أس أربعة هذا الـ strain energy
+
+322
+00:40:32,780 --> 00:40:37,460
+due to bending طيب في عندي الـ strain energy due to
+
+323
+00:40:37,460 --> 00:40:47,640
+transverse shear U due to transverse shear اللي
+
+324
+00:40:47,640 --> 00:40:50,500
+هي مواطنة على الأقل U هتكون تساوي تكامل
+
+325
+00:41:20,450 --> 00:41:26,540
+معناه  تحسين عن دي؟ تكامل 1.11 الـ V
+
+326
+00:41:26,540 --> 00:41:34,240
+بيساوي F بصير ان دي F تربيع على اتنين الـ A عبارة
+
+327
+00:41:34,240 --> 00:41:46,660
+عن باي على أربعة D تربيع في G DX  حسنا
+
+328
+00:41:46,660 --> 00:41:47,540
+ان دي 1
+
+329
+00:41:51,430 --> 00:42:04,710
+1.1 في 2 F تربيع على باي D تربيع في
+
+330
+00:42:04,710 --> 00:42:10,970
+G في L معناته
+
+331
+00:42:10,970 --> 00:42:13,710
+الـ total strain energy هتكون U transverse shear
+
+332
+00:42:13,710 --> 00:42:19,270
+stress زي U bending moment هتكون تساوي اللي هي
+
+333
+00:42:19,270 --> 00:42:27,910
+حجمه 2.22 F تربيع L على
+
+334
+00:42:27,910 --> 00:42:37,490
+باي D تربيع G زائد U bending moment 2 و
+
+335
+00:42:37,490 --> 00:42:51,630
+30 F تربيع L تكعيب على 3
+
+336
+00:42:58,820 --> 00:43:11,600
+E باي D أس أربعة يعني لو بدنا نبسط أكتر شوية أخذنا F
+
+337
+00:43:11,600 --> 00:43:21,380
+تربيع L على باي D تربيع F تربيع L على باي D تربيع
+
+338
+00:43:21,380 --> 00:43:25,680
+بالساوى 2
+
+339
+00:43:27,420 --> 00:43:38,980
+بوينت 2.22 على G زائد 2 و 30
+
+340
+00:43:38,980 --> 00:43:42,140
+التربيع
+
+341
+00:43:42,140 --> 00:43:45,340
+على
+
+342
+00:43:45,340 --> 00:43:48,980
+3
+
+343
+00:43:48,980 --> 00:43:51,880
+E D تربيع
+
+344
+00:43:57,630 --> 00:44:03,050
+هيك يكون وجدنا total strain energy due to both
+
+345
+00:44:03,050 --> 00:44:08,050
+اللي هو transverse shear loading و bending loading
+
+346
+00:44:08,050 --> 00:44:14,770
+المحاضرة الجاية بنكمل
+
+347
+00:44:14,770 --> 00:44:17,990
+في الـ strain energy بس هندرس شيء اسمه Castigliano
+
+348
+00:44:17,990 --> 00:44:22,630
+theorem عشان نوجد deflection عند أي موقع في .. في
+
+349
+00:44:22,630 --> 00:44:25,370
+.. في beam تحت أثر أحمال
diff --git a/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/A-1SThU8Qv4_raw.srt b/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/A-1SThU8Qv4_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..593ed38b014972c6b77228094cf3da2ab40b77a3
--- /dev/null
+++ b/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/A-1SThU8Qv4_raw.srt
@@ -0,0 +1,1396 @@
+1
+00:00:05,090 --> 00:00:09,710
+السلام عليكم اليوم هنكمل chapter أربعة او
+
+2
+00:00:09,710 --> 00:00:14,490
+deflection and stiffness of beams في المحاضرة اللي
+
+3
+00:00:14,490 --> 00:00:17,930
+الفاتة تعرفنا ال elasticity اللي هي خاصية للمادة
+
+4
+00:00:17,930 --> 00:00:23,030
+بتمكنها من استعادة شكلها بمجرد رفع الأحمال ال
+
+5
+00:00:23,030 --> 00:00:26,030
+spraying جايبها عن mechanical element اللي لو
+
+6
+00:00:26,030 --> 00:00:27,870
+عملتله deflection بيعطيني force
+
+7
+00:00:30,960 --> 00:00:34,700
+ال spring rate اللي هو كان عرفناه K بيساوي DF على
+
+8
+00:00:34,700 --> 00:00:40,540
+DY في حالة linear spring ال K بيساوي F على Y عرفنا
+
+9
+00:00:40,540 --> 00:00:44,280
+ال spring او we derive ال spring constant ل X
+
+10
+00:00:44,280 --> 00:00:49,000
+reloaded member كان ال K بيساوي A في E على L في
+
+11
+00:00:49,000 --> 00:00:53,400
+حالة torsion reloaded member كان عنده ال stiffness
+
+12
+00:00:53,400 --> 00:00:57,360
+constant او ال stiffness rate K بيساوي G في G على
+
+13
+00:00:57,360 --> 00:00:58,140
+L
+
+14
+00:01:01,070 --> 00:01:04,410
+بعدين درسنا deflection due to bending in straight
+
+15
+00:01:04,410 --> 00:01:10,550
+beams وصلنا لعلاقة أنه ال bending moment M على EI
+
+16
+00:01:10,550 --> 00:01:15,930
+بساوة D²Y بDX² باستخدام العلاقة هذه ممكن يوجد
+
+17
+00:01:15,930 --> 00:01:22,370
+slope أو و a deflection at any point along the
+
+18
+00:01:22,370 --> 00:01:30,150
+beam as a function of X حلينا two examplesجيب ده
+
+19
+00:01:30,150 --> 00:01:34,690
+الـ deflection و ال slopes at any location for a
+
+20
+00:01:34,690 --> 00:01:40,450
+beam عليه distributed load باستخدام معادلة اللي هي
+
+21
+00:01:40,450 --> 00:01:46,410
+M على EI بيستوى D²Y بقى DX² بعد حكينا فيه أكتر من
+
+22
+00:01:46,410 --> 00:01:50,550
+طريقة لحسابات الـ deflection منها superposition ال
+
+23
+00:01:50,550 --> 00:01:55,710
+numerical integration و Castellano methodبدأنا في
+
+24
+00:01:55,710 --> 00:01:59,190
+ال superposition ال superposition بتحكي ببساطة ان
+
+25
+00:01:59,190 --> 00:02:03,870
+ال total effect due to the combined loading
+
+26
+00:02:03,870 --> 00:02:09,670
+condition بيساوي مجموع ال individual effect due to
+
+27
+00:02:09,670 --> 00:02:14,070
+individual loading conditions طبعا عشان نحل ال
+
+28
+00:02:14,070 --> 00:02:18,550
+superposition هنستخدم table A9 في الكتاب حلينا
+
+29
+00:02:18,550 --> 00:02:22,430
+exam الأربعة اتنين باستخدام ال superposition
+
+30
+00:02:26,090 --> 00:02:29,990
+هنحل المسألة التانية باستخدام ال support position
+
+31
+00:02:29,990 --> 00:02:36,930
+هنحل المسألة التالية determine the deflection
+
+32
+00:02:36,930 --> 00:02:40,230
+equations using support position for the given
+
+33
+00:02:40,230 --> 00:02:47,480
+beam في عند beam simply supported عند a و bوطاير
+
+34
+00:02:47,480 --> 00:02:52,680
+من B ل C فيه بأثر على الـ distributed load بين A
+
+35
+00:02:52,680 --> 00:02:59,300
+وB وفيه concentrated load عند طرف الطاير C معناته
+
+36
+00:02:59,300 --> 00:03:06,060
+هنا عندي support عندي
+
+37
+00:03:06,060 --> 00:03:06,880
+hand support
+
+38
+00:03:13,250 --> 00:03:16,210
+بنحسب ال reactions و ال deflections due to this
+
+39
+00:03:16,210 --> 00:03:23,110
+loading condition باستخدام ال superposition أنا
+
+40
+00:03:23,110 --> 00:03:28,750
+المثل هذه عشان أحلها لازم أجزئها بحيث ممكن أستخدم
+
+41
+00:03:28,750 --> 00:03:33,650
+الجداول في appendix A9 يعني المثل كله ممكن أحكي
+
+42
+00:03:33,650 --> 00:03:38,030
+التالي أنا عندي هاي ال total condition
+
+43
+00:03:49,330 --> 00:03:57,050
+عندي هنا distributed
+
+44
+00:03:57,050 --> 00:04:07,870
+load W وعندي هنا total load F هذا اللي كنا نحكيه
+
+45
+00:04:07,870 --> 00:04:11,690
+انها عبارة هذا ال total effect عبارة عن مجموع two
+
+46
+00:04:11,690 --> 00:04:13,590
+effects ال effect الأولاني
+
+47
+00:04:24,080 --> 00:04:34,440
+عبارة عن distributed load زائد
+
+48
+00:04:34,440 --> 00:04:37,980
+concentrated
+
+49
+00:04:37,980 --> 00:04:38,620
+load
+
+50
+00:04:55,340 --> 00:05:00,800
+F معناته هذا ال total effect عندي distributed load
+
+51
+00:05:00,800 --> 00:05:05,420
+وعندي concentrated load هذا عبارة عن مجموع ال two
+
+52
+00:05:05,420 --> 00:05:10,920
+effects ال effect due to concentrated load W و ال
+
+53
+00:05:10,920 --> 00:05:15,160
+effect due to concentrated load F طبعا هكون عندي
+
+54
+00:05:15,160 --> 00:05:18,940
+due
+
+55
+00:05:18,940 --> 00:05:28,890
+to this في عندي هين عندي هين هكونR1' وهنا عنده R2'
+
+56
+00:05:30,230 --> 00:05:35,990
+وهنا رح يكون عنده R1W'
+
+57
+00:05:36,610 --> 00:05:40,510
+وهنا R2W'
+
+58
+00:05:41,210 --> 00:05:47,890
+وفي عندي برضه هنا Y' due to this deflection وYW'
+
+59
+00:05:48,410 --> 00:05:50,090
+due to this deflection
+
+60
+00:05:55,670 --> 00:06:04,310
+معناته هاخد two conditions الحالة
+
+61
+00:06:04,310 --> 00:06:09,150
+الأولى .. الحالة الأولى عبارة عن distributed load
+
+62
+00:06:37,290 --> 00:06:52,830
+و الحالة التانية عبارة عن concentrated load F
+
+63
+00:06:52,830 --> 00:07:05,750
+هنا عندي R1 prime و R2 prime هنا عندي R1double
+
+64
+00:07:05,750 --> 00:07:13,930
+prime وهنا عندي R2 double prime بدي
+
+65
+00:07:13,930 --> 00:07:17,770
+أشوف loading condition موجودة في ال table تشبه هذه
+
+66
+00:07:17,770 --> 00:07:20,050
+الحالة و loading condition موجودة في ال table
+
+67
+00:07:20,050 --> 00:07:25,090
+مكافئة للحالة هذه لما
+
+68
+00:07:25,090 --> 00:07:29,030
+بالنسبة للحالة الأولى هذه هتكون الحالة المكافئة
+
+69
+00:07:29,030 --> 00:07:31,470
+اللي هي A
+
+70
+00:07:33,510 --> 00:07:38,570
+تسعة سبعة اية السبعة الاية هذه بس بختلف ان انا
+
+71
+00:07:38,570 --> 00:07:44,210
+عندي F فيه زيادة هنا يعني هكون في عندي ايش فيه
+
+72
+00:07:44,210 --> 00:07:50,310
+زيادة طول هذا هو ال deflected beam ال
+
+73
+00:07:50,310 --> 00:07:56,250
+R واحد ال prime هتكون
+
+74
+00:07:56,250 --> 00:08:06,060
+بالساوي زي ما انتوا شايفينبيستوى R2' بيستوى
+
+75
+00:08:06,060 --> 00:08:15,820
+WL .. خنت أتأكد أن التسمية تانية هنا WL على
+
+76
+00:08:15,820 --> 00:08:25,540
+اتنين هذه .. هذه بالمناسبة هذه .. هذه L وهذه إيش؟
+
+77
+00:08:25,540 --> 00:08:25,860
+A
+
+78
+00:08:32,630 --> 00:08:39,350
+ال و إيه؟
+
+79
+00:08:39,350 --> 00:08:49,950
+ال و إيه؟ و نفس الأش عندهين ال
+
+80
+00:08:49,950 --> 00:08:56,490
+و إيه؟ و هنا ال
+
+81
+00:08:56,490 --> 00:08:58,070
+و إيه؟
+
+82
+00:09:02,500 --> 00:09:05,360
+والـ deflection من النقطة هدا نقطة هاد is given by
+
+83
+00:09:05,360 --> 00:09:14,880
+this equation الـ Y' لهذه الحالة Y' هتساوي
+
+84
+00:09:14,880 --> 00:09:23,300
+اللي هو WX على
+
+85
+00:09:23,300 --> 00:09:30,800
+24EI في 2LX تربيع
+
+86
+00:09:36,110 --> 00:09:40,710
+ناقص X تكييب ناقص
+
+87
+00:09:40,710 --> 00:09:55,670
+L تكييب طبعا هذه العلاقة X من سفر ل L الان
+
+88
+00:09:55,670 --> 00:09:57,110
+due to loading
+
+89
+00:10:08,660 --> 00:10:20,000
+عندي a,b,c عندي هي a,b,c الأعناء ال beam هيكون ال
+
+90
+00:10:20,000 --> 00:10:26,620
+deflection بتاعه عندي
+
+91
+00:10:26,620 --> 00:10:27,260
+هي a
+
+92
+00:10:37,230 --> 00:10:57,850
+A B C ال deflection هتحصير بالشكل هذا يعني
+
+93
+00:10:57,850 --> 00:11:01,830
+هذه المعادلة تطيل ال deflection من A ل B من النقطة
+
+94
+00:11:01,830 --> 00:11:04,690
+هذه لنقطة هذه لأن من B ل C
+
+95
+00:11:09,310 --> 00:11:13,930
+يعني هيضل ال slope من B ل C هيضل ال slope constant
+
+96
+00:11:13,930 --> 00:11:22,550
+يعني لو جت slope اللي أنا عندي y prime dy by dx ل
+
+97
+00:11:22,550 --> 00:11:32,070
+y prime هتكون W على 24EI هذا بشكل عام فيه
+
+98
+00:11:36,920 --> 00:11:46,560
+هكون ستة ال X تربيع ناقص
+
+99
+00:11:46,560 --> 00:11:56,960
+أربعة X تكييب ناقص التكييب هذا at any location بين
+
+100
+00:11:56,960 --> 00:12:03,220
+X .. بين X for X هنا بين سفر و L
+
+101
+00:12:07,210 --> 00:12:15,450
+at x equal L يعني dy by dx prime at x بالساوية L
+
+102
+00:12:15,450 --> 00:12:22,910
+هتكون تساوية W
+
+103
+00:12:22,910 --> 00:12:32,770
+على أربع وعشرين EI في ستة
+
+104
+00:12:32,770 --> 00:12:35,250
+التكييب
+
+105
+00:12:37,040 --> 00:12:47,400
+ناقص أربعة التكييب ناقص التكييب حيساوى
+
+106
+00:12:47,400 --> 00:12:53,860
+ستة ناقص أربعة اتنين ناقص واحد واحد حيكون W
+
+107
+00:12:53,860 --> 00:13:07,780
+التكييب على أربعة وعشرينE في I هذا ال slope اللي
+
+108
+00:13:07,780 --> 00:13:15,580
+هي هذه الذرة theta هذا ال slope الان هذه المسافة
+
+109
+00:13:15,580 --> 00:13:20,040
+او
+
+110
+00:13:20,040 --> 00:13:23,720
+عند اي location عند اي location X
+
+111
+00:13:27,210 --> 00:13:31,350
+هذه المسافة هتكون إيه؟ X معناته هذه المسافة هتكون
+
+112
+00:13:31,350 --> 00:13:40,590
+إيه؟ X minus L at
+
+113
+00:13:40,590 --> 00:13:50,210
+X at any location X at any location at any
+
+114
+00:13:50,210 --> 00:13:52,870
+location
+
+115
+00:13:57,520 --> 00:14:06,920
+x بكل slope اللي هو tan θ اللي
+
+116
+00:14:06,920 --> 00:14:20,180
+هو عبارة عن dy by dx اللي هو هذا tan θ هكون w ال
+
+117
+00:14:20,180 --> 00:14:34,070
+تكيب على 24EI بتساوي ال slope هيكون اللي هو ال Y
+
+118
+00:14:34,070 --> 00:14:40,690
+على
+
+119
+00:14:40,690 --> 00:14:52,030
+X ناقص L X ناقص L معناته
+
+120
+00:14:52,030 --> 00:14:53,130
+Y prime
+
+121
+00:14:59,250 --> 00:15:12,550
+بالساوية W التكييب في X ناقص
+
+122
+00:15:12,550 --> 00:15:18,950
+L على 24EI
+
+123
+00:15:18,950 --> 00:15:24,870
+طبعا هذه عند N في المنطقة هذه بس بين B وC معناته
+
+124
+00:15:25,560 --> 00:15:27,700
+ممكن احكي الـ deflection due to the distributed
+
+125
+00:15:27,700 --> 00:15:36,680
+load هيكون Y' Y'
+
+126
+00:15:37,180 --> 00:15:41,120
+بيساوي
+
+127
+00:15:41,120 --> 00:15:50,840
+جزئين الجزء الأول هيكون
+
+128
+00:15:50,840 --> 00:15:54,360
+هذا اللي هو WX
+
+129
+00:16:01,160 --> 00:16:06,180
+انتبه هنا للإشارات لل
+
+130
+00:16:06,180 --> 00:16:12,240
+.. للإشارات إذا عوضت مثلا X بالساوية L على 2 X L
+
+131
+00:16:12,240 --> 00:16:17,220
+على 2 هتكون ال Y Maximum minus 5WL أربع على تلاتين
+
+132
+00:16:17,220 --> 00:16:26,840
+على اتنين في E على I الآن ال Y Prime هتكون WX على
+
+133
+00:16:26,840 --> 00:16:30,560
+أربع و عشرين EI
+
+134
+00:16:32,400 --> 00:16:48,740
+في اتنين L X تربيع minus X تكييب minus L تكييب X
+
+135
+00:16:48,740 --> 00:16:56,840
+بين سفر و L الفترة التانية هتكون
+
+136
+00:17:01,660 --> 00:17:06,820
+بتكون تساوي W L
+
+137
+00:17:06,820 --> 00:17:20,620
+تكيب على 24 EI في
+
+138
+00:17:20,620 --> 00:17:25,520
+X minus
+
+139
+00:17:25,520 --> 00:17:39,970
+L طبعا هنا Xأكبر من L و أصغر من L زائد A معناته
+
+140
+00:17:39,970 --> 00:17:45,530
+we find deflection due to this loading condition
+
+141
+00:17:45,530 --> 00:17:50,670
+اللي هناخد الحالة التانية الحالة هذه
+
+142
+00:17:58,180 --> 00:18:05,200
+load أو ال beam تحت أثير قوة مركزة عند الطرف الحر
+
+143
+00:18:05,200 --> 00:18:12,440
+نرجع
+
+144
+00:18:12,440 --> 00:18:20,600
+للمسألة تاعتنا أقرب
+
+145
+00:18:20,600 --> 00:18:27,060
+حالة للحالة تاعتنا اللي هي appendix A
+
+146
+00:18:29,830 --> 00:18:36,890
+تسعة عشرة معطيني
+
+147
+00:18:36,890 --> 00:18:44,890
+هنا R واحد double prime بتساوي
+
+148
+00:18:44,890 --> 00:18:55,230
+FA على L وR اتنين double
+
+149
+00:18:55,230 --> 00:18:58,490
+prime بتساوي
+
+150
+00:19:02,130 --> 00:19:09,290
+بس انتبهوا للإشارات R واحد احنا هتكون بالسالب انا
+
+151
+00:19:09,290 --> 00:19:17,950
+جاله تحت هتكون بالسالب و R اتنين double prime F
+
+152
+00:19:17,950 --> 00:19:29,130
+على L في L زائد A بالنسبال
+
+153
+00:19:29,130 --> 00:19:36,560
+ال deflectionالـ deflection عبارة عن مقطعين فيه
+
+154
+00:19:36,560 --> 00:19:41,300
+deflection معادلة من a ل b و فيه معادلة من b ل c
+
+155
+00:19:41,300 --> 00:19:50,620
+يعني هيكون عندي y double prime من
+
+156
+00:19:50,620 --> 00:19:58,580
+a ل b هيكون fax على
+
+157
+00:19:58,580 --> 00:19:59,440
+6eil
+
+158
+00:20:04,770 --> 00:20:10,870
+في L تربية نقص X تربية يعني
+
+159
+00:20:10,870 --> 00:20:16,610
+هنا X بين سفر و
+
+160
+00:20:16,610 --> 00:20:24,910
+L و المقطع التاني FX-L
+
+161
+00:20:24,910 --> 00:20:31,130
+على 6EI
+
+162
+00:20:36,700 --> 00:20:50,060
+في x ناقص L الكل تربية minus
+
+163
+00:20:50,060 --> 00:21:03,810
+a في تلاتة x minus Lو X أكبر أو يساوي L أخر يساوي
+
+164
+00:21:03,810 --> 00:21:09,950
+A زائد L معناته
+
+165
+00:21:09,950 --> 00:21:12,830
+إحنا وجدنا ال individual effect for each loading
+
+166
+00:21:12,830 --> 00:21:18,810
+condition وجدنا R1 prime وR2 prime وY prime ووجدنا
+
+167
+00:21:18,810 --> 00:21:22,270
+ال individual effect due to this loading condition
+
+168
+00:21:22,270 --> 00:21:27,110
+عندي R1 prime وR2 prime وY W prime معناته ال total
+
+169
+00:21:27,110 --> 00:21:34,500
+effect ال R1R1' R1W'
+
+170
+00:21:35,080 --> 00:21:49,200
+R1' WL 2-FA L R2
+
+171
+00:21:49,200 --> 00:21:54,440
+R2' R2W'
+
+172
+00:21:55,400 --> 00:22:12,040
+WLعلى اتنين زائد F على L في L زائد A ال
+
+173
+00:22:12,040 --> 00:22:17,020
+total deflection ال Y بيساوي
+
+174
+00:22:17,020 --> 00:22:24,180
+Y prime زائد Y W prime يعني ال Y هتكون الساوى
+
+175
+00:22:26,000 --> 00:22:33,100
+المقطع الأولاني الـ WX الـ
+
+176
+00:22:33,100 --> 00:22:38,900
+WX الـ
+
+177
+00:22:38,900 --> 00:22:54,740
+WX على 24 EI في 2 L X تربيع minus X تكييب minus L
+
+178
+00:22:54,740 --> 00:23:11,820
+تكييبزاد F A X على 6 E I L في L تربيع و minus X
+
+179
+00:23:11,820 --> 00:23:18,920
+تربيع طبعا هنا X من صفر لأقل المقطع التاني اللي هو
+
+180
+00:23:18,920 --> 00:23:22,880
+W L
+
+181
+00:23:22,880 --> 00:23:34,590
+تكيبعلى 24EI في X minus L زائد
+
+182
+00:23:34,590 --> 00:23:51,410
+F في X minus L على 6EI في X minus L الكل تربيع
+
+183
+00:23:51,410 --> 00:24:01,900
+minus Aفي تلاتة X minus L هنا X أكبر أو يساوي L
+
+184
+00:24:01,900 --> 00:24:09,700
+أزال يساوي A زائد L هيك وجدنا ال total effect
+
+185
+00:24:09,700 --> 00:24:13,300
+وجدنا ال reactions R واحد وR اتنين و ال total
+
+186
+00:24:13,300 --> 00:24:19,360
+deflection at any location Y و to double check ال
+
+187
+00:24:19,360 --> 00:24:27,900
+calculation بتاعتكعوض X بالساوية سفر هتعطيني ايش؟
+
+188
+00:24:27,900 --> 00:24:33,040
+Deflection بالساوية سفر عوض X بالساوية L هي سفر
+
+189
+00:24:33,040 --> 00:24:36,520
+وهي سفر معناته الاشي صحيح
+
+190
+00:25:21,630 --> 00:25:28,630
+إذا عندى زنبرك و سحبت وضلت من ال mask بيكون فى
+
+191
+00:25:28,630 --> 00:25:32,990
+طاقة مقتزنة بسميها strain energy هذه الطاقة
+
+192
+00:25:32,990 --> 00:25:37,650
+المقتزنة نتيجة إن فى عليه deflection لو سيبت طرف
+
+193
+00:25:38,540 --> 00:25:41,900
+الزنبارك هيرجع معناته في potential energy طالما
+
+194
+00:25:41,900 --> 00:25:46,200
+أنا مسكها هي ممسوكة طالما فلاتتها هيرجع الزنبارك
+
+195
+00:25:46,200 --> 00:25:50,920
+لحاله معناته هيكون في عندي شغل أو طاقة مختزنة
+
+196
+00:25:50,920 --> 00:25:54,860
+بسميها strain energy due to deflection إذا عند
+
+197
+00:25:54,860 --> 00:26:04,860
+زنبارك هاي X هاي F وlinear spring عكينا الشغل
+
+198
+00:26:04,860 --> 00:26:11,240
+عبارة عن أياشالشغل عبارة عن force في distance
+
+199
+00:26:11,240 --> 00:26:19,400
+معناه الشغل من هنا ل هنا هيكون المساعة تحت الممحنة
+
+200
+00:26:19,400 --> 00:26:30,580
+هيكون الشغل U هيكون مساعة مثلث نص نص
+
+201
+00:26:30,580 --> 00:26:35,320
+هذه F نص في X في F
+
+202
+00:26:39,040 --> 00:26:44,620
+و ال X احنا عارفينها عبارة عن عندي برضه ال F
+
+203
+00:26:44,620 --> 00:26:50,420
+بالساوية K في X معناته ال X بالساوية F على K يعني
+
+204
+00:26:50,420 --> 00:26:58,460
+هتكون في F على K هتكون نص F Square على K اللي هي
+
+205
+00:26:58,460 --> 00:27:03,880
+زي ما يبين عندى ال U سواء F Square على 2K
+
+206
+00:27:12,760 --> 00:27:19,180
+معناته ال strain energy هتكون ال
+
+207
+00:27:19,180 --> 00:27:31,400
+U بسوة F2 على 2K في
+
+208
+00:27:31,400 --> 00:27:33,860
+حالة axially loaded member axially loaded member
+
+209
+00:27:33,860 --> 00:27:43,160
+يعني هاي axially loaded member تحت اثير Fاحنا
+
+210
+00:27:43,160 --> 00:27:48,400
+حكينا ال K تعني تعني ايش كان سواء ال K؟ A E على L
+
+211
+00:27:48,400 --> 00:27:51,440
+يعني
+
+212
+00:27:51,440 --> 00:27:59,340
+ال U هتكون سواء F Square على 2 في ال K اللي هي A E
+
+213
+00:27:59,340 --> 00:28:07,930
+على Lيعني هتكون .. هتطلع ال L هصير F squared L على
+
+214
+00:28:07,930 --> 00:28:15,350
+اتنين A E هذا في حالة كان ال cross section ثابت و
+
+215
+00:28:15,350 --> 00:28:21,290
+في حال كانت ال force ثابتة الآن لو كانت ال cross
+
+216
+00:28:21,290 --> 00:28:26,930
+section متغير أو و ال force متغيرة بيصير ان ال L
+
+217
+00:28:26,930 --> 00:28:33,390
+بيصير بدلها ايش DX يعني هصير انديوبيساوي F squared
+
+218
+00:28:33,390 --> 00:28:40,190
+DX على اتنين A A و ال U هيكوناش ال integration
+
+219
+00:28:40,190 --> 00:28:48,890
+يعني ال U هيكون تكامل F squared DX على اتنين A A
+
+220
+00:28:48,890 --> 00:28:58,690
+هذا في حالة X reloaded member في
+
+221
+00:28:58,690 --> 00:28:59,810
+حالة original
+
+222
+00:29:02,740 --> 00:29:07,340
+Torsional Torsional loaded member فاكرين أن ال K
+
+223
+00:29:07,340 --> 00:29:15,500
+كان سوى GG على L ال K سوى GG على L ال U نرجع
+
+224
+00:29:15,500 --> 00:29:23,000
+للمعادل الأصلية ال U بسوء F square على 2K
+
+225
+00:29:26,010 --> 00:29:32,390
+و ال K في الحالة هت يعني بتساوي يعني ال F is
+
+226
+00:29:32,390 --> 00:29:42,430
+analog لل torque و ال K عبارة عن GG على L يعني ال
+
+227
+00:29:42,430 --> 00:29:47,570
+U في حالة torque in loaded member هتكون عوض عن F
+
+228
+00:29:47,570 --> 00:29:55,320
+في Tعلى اتنين في K اللي هو G G على L يعني هتكون
+
+229
+00:29:55,320 --> 00:30:04,480
+سوا T square L على اتنين G في G هدف الحال كان ال
+
+230
+00:30:04,480 --> 00:30:09,560
+torque constant و المقطع constant مع الطول لو كان
+
+231
+00:30:09,560 --> 00:30:17,950
+واحد من ال torque او المقطع متغير مع الطولأو
+
+232
+00:30:17,950 --> 00:30:23,730
+كلاهما بيصير عند ال U تكامل بيصير ال U ساوى تكامل
+
+233
+00:30:23,730 --> 00:30:33,130
+T squared على اتنين GJDX في
+
+234
+00:30:33,130 --> 00:30:38,290
+حالة direct shear loading هذا direct شيري هذا
+
+235
+00:30:38,290 --> 00:30:43,440
+torsional shear في حالة direct shear loadingبيكون
+
+236
+00:30:43,440 --> 00:30:46,540
+الـ strain energy due to direct shear is given by
+
+237
+00:30:46,540 --> 00:30:51,460
+this equation الـ
+
+238
+00:30:51,460 --> 00:30:55,140
+A مساحة المقطع الـ G ال modulus of rigidity في حال
+
+239
+00:30:55,140 --> 00:30:59,000
+كانت ال force متغيرة قيمتها أو ال cross section
+
+240
+00:30:59,000 --> 00:31:02,720
+بتغير من مكان لمكان بيصير تتحول لمعادلة
+
+241
+00:31:02,720 --> 00:31:10,000
+integration في حال
+
+242
+00:31:10,000 --> 00:31:17,250
+bending هذاbending condition ال .. ال .. ال strain
+
+243
+00:31:17,250 --> 00:31:20,770
+energy due to bending is given by this equation M
+
+244
+00:31:20,770 --> 00:31:24,130
+squared L على 2EI هذا في حالة كانت ال bending
+
+245
+00:31:24,130 --> 00:31:29,530
+moment ثابتة مع الطول و المقطع ثابت مع الطول في
+
+246
+00:31:29,530 --> 00:31:36,540
+حالة كان المقطع متغير مع الطولأو و البنجم هو متغير
+
+247
+00:31:36,540 --> 00:31:39,500
+مع المقطع والطول بيصير عندي list of energy is
+
+248
+00:31:39,500 --> 00:31:42,800
+given by this equation تكامل M squared على 2 EI DX
+
+249
+00:31:53,660 --> 00:31:58,260
+في حالة transverse shear loading يعني بيكون عندى
+
+250
+00:31:58,260 --> 00:32:01,760
+bending يعني عندى ال load هنا بس بيكون shear هنا
+
+251
+00:32:01,760 --> 00:32:05,180
+يعني ال shear متجه عند ال load هذا بيسمى
+
+252
+00:32:05,180 --> 00:32:08,640
+transverse shear condition في الحالة ده ال U
+
+253
+00:32:08,640 --> 00:32:15,740
+بيستوى C في V square L على 2A في Gال V اللي هو ال
+
+254
+00:32:15,740 --> 00:32:20,220
+shear load أو ال transverse shear ال L الطول ال M
+
+255
+00:32:20,220 --> 00:32:24,900
+المقطع و ال G ال modulus of rigidity و ال C
+
+256
+00:32:24,900 --> 00:32:29,820
+modifier constant بيعتمد على شكل المقطع الشكل
+
+257
+00:32:29,820 --> 00:32:34,340
+المقطع ممكن مدور مستطيل مثلث ال C تعتمد على شكل
+
+258
+00:32:34,340 --> 00:32:35,380
+المقطع
+
+259
+00:32:43,240 --> 00:32:48,160
+جدول اربعة واحد ماعطيني ال modifier factor C في
+
+260
+00:32:48,160 --> 00:32:54,690
+حالة transverse shear loading conditionمقطع شكله
+
+261
+00:32:54,690 --> 00:32:58,330
+مستطيل ال C بيكون سواء واحد point اتنين في حالة
+
+262
+00:32:58,330 --> 00:33:02,590
+مقطع شكله مدور بتكون ال C two point one one في
+
+263
+00:33:02,590 --> 00:33:06,650
+حالة المقطع عبارة عن انبوب مدورة و رفيعة بتكون ال
+
+264
+00:33:06,650 --> 00:33:10,950
+C بيساوي اتنين في حالة box section بتكون ساوي ال
+
+265
+00:33:10,950 --> 00:33:20,670
+ال ال ال ال C بيساوي واحد نشوف مثال هذا
+
+266
+00:33:20,670 --> 00:33:25,400
+المثال الليهنحل السؤال هذا وننهي المحاضرة ان شاء
+
+267
+00:33:25,400 --> 00:33:28,800
+الله
+
+268
+00:33:28,800 --> 00:33:45,280
+ال
+
+269
+00:33:45,280 --> 00:33:51,000
+cantilever beamwith around cross section with
+
+270
+00:33:51,000 --> 00:33:53,920
+around cross section the cantilever beam مقطعه
+
+271
+00:33:53,920 --> 00:34:01,520
+مدور مقطعته مدور has a concentrated load F at the
+
+272
+00:34:01,520 --> 00:34:07,540
+end فيه load مركز عند الطرف قيمة ال load F
+
+273
+00:34:09,720 --> 00:34:15,800
+Find the strain energy in the beam أولا
+
+274
+00:34:15,800 --> 00:34:18,360
+عشان أحل مثل زيك لازم I have to define ال
+
+275
+00:34:18,360 --> 00:34:25,940
+coordinate system تبعي عندي هاي ال Y هذا
+
+276
+00:34:25,940 --> 00:34:32,300
+ال Y هذا
+
+277
+00:34:32,300 --> 00:34:43,120
+ال Xباخد على مسافة باخد هي section على بعد X
+
+278
+00:34:43,120 --> 00:34:58,660
+و باخد free body diagram عند
+
+279
+00:34:58,660 --> 00:34:59,760
+هذه ال force F
+
+280
+00:35:05,100 --> 00:35:13,440
+و هذه المسافة X أكيد
+
+281
+00:35:13,440 --> 00:35:21,400
+هيعكسها force F احيانا او خلينا نسميها V هتعمل
+
+282
+00:35:21,400 --> 00:35:28,640
+counter clockwise moment هتعكسها clockwise moment
+
+283
+00:35:28,640 --> 00:35:31,840
+وهي
+
+284
+00:35:31,840 --> 00:35:44,400
+عند ال Xو هاي ال Y اللي
+
+285
+00:35:44,400 --> 00:35:51,300
+أخد submission of forces بتجاه
+
+286
+00:35:51,300 --> 00:36:00,490
+ال Y بالساوة Zeroهيكون عندي minus F زائد V يعني ال
+
+287
+00:36:00,490 --> 00:36:12,570
+V لترانزل شير ايه شو ساوي؟ F لاخدت
+
+288
+00:36:12,570 --> 00:36:18,450
+ال .. ال .. ال moment هين summation of moment
+
+289
+00:36:18,450 --> 00:36:29,840
+حوالين نقطة X بالساوية سفرهيكون minus F في X زائد
+
+290
+00:36:29,840 --> 00:36:40,780
+M يعني ال M هستوى عندي إيه؟ F في X طيب
+
+291
+00:36:40,780 --> 00:36:46,640
+اللحظة و أنا عندي at any cross section at any
+
+292
+00:36:46,640 --> 00:36:51,140
+cross
+
+293
+00:36:51,140 --> 00:36:51,600
+section
+
+294
+00:36:55,670 --> 00:37:00,210
+we have bending
+
+295
+00:37:00,210 --> 00:37:04,790
+moment
+
+296
+00:37:04,790 --> 00:37:09,210
+and
+
+297
+00:37:09,210 --> 00:37:13,610
+transverse
+
+298
+00:37:13,610 --> 00:37:18,410
+shear معناته
+
+299
+00:37:18,410 --> 00:37:23,310
+total strain energy ال U هتكون U U ت transverse
+
+300
+00:37:23,310 --> 00:37:33,650
+shearthe due due to pending moment نرجع
+
+301
+00:37:33,650 --> 00:37:49,430
+لمعادلات due
+
+302
+00:37:49,430 --> 00:37:51,130
+to pending moment you
+
+303
+00:37:54,880 --> 00:38:04,860
+due to bending moment المعادلة هذه بيساوي تكامل M2
+
+304
+00:38:04,860 --> 00:38:11,400
+على 2EIDX
+
+305
+00:38:11,400 --> 00:38:19,300
+حيث ساوى طبعا التكامل حق من 0 لL هيكون تكامل من 0
+
+306
+00:38:19,300 --> 00:38:26,470
+لLالـ M هيبقى عبارة عن F X حاسس أن عندي F تربية X
+
+307
+00:38:26,470 --> 00:38:35,050
+تربية على 2EI DX لاحظوا أن المقطع ثابت و ال force
+
+308
+00:38:35,050 --> 00:38:37,370
+ثابتة هيطلع عبارة عن ال integration هيكون الساوية
+
+309
+00:38:37,370 --> 00:38:48,450
+F square على 2EI تكامل X
+
+310
+00:38:48,450 --> 00:38:56,200
+تربيةDX من سفر لأقل يعني إذا بعملها تكامل هتكون F2
+
+311
+00:38:56,200 --> 00:39:06,600
+على 2EI ل X تكييب على 3 من سفر لأقل يعني هتكون
+
+312
+00:39:06,600 --> 00:39:17,960
+تساوي F تربيع التكييب على 6EI
+
+313
+00:39:22,040 --> 00:39:27,940
+الان المقطع المدور ال I للمقطع المدور ال I للمقطع
+
+314
+00:39:27,940 --> 00:39:33,680
+المدور عبارة عن باي على أربع و ستين D أس أربعة
+
+315
+00:39:33,680 --> 00:39:38,240
+يعني
+
+316
+00:39:38,240 --> 00:39:47,900
+هتصير ال U to bending moment هتكون تساوي F
+
+317
+00:39:47,900 --> 00:39:57,450
+تربيعالتا كيب على ستة ا في I اللي هي باي على أربع
+
+318
+00:39:57,450 --> 00:40:06,730
+ستين ديقص أربعة هتساوي
+
+319
+00:40:06,730 --> 00:40:11,150
+اتنين
+
+320
+00:40:11,150 --> 00:40:18,230
+و تلاتين F تربيع ال تا كيب
+
+321
+00:40:21,780 --> 00:40:32,780
+على تلاتة E by D أُص أربعة هذا ال strain energy
+
+322
+00:40:32,780 --> 00:40:37,460
+due to bending طيب في عندي ال strain energy due to
+
+323
+00:40:37,460 --> 00:40:47,640
+transverse shear U due to transverse shear اللي
+
+324
+00:40:47,640 --> 00:40:50,500
+هي مواطنة على الأقل U هتكون تستاوية تكامل
+
+325
+00:41:20,450 --> 00:41:26,540
+معناه تحسين عن دي؟تكامل واحد point واحد واحد ال V
+
+326
+00:41:26,540 --> 00:41:34,240
+بيستوى F بصير ان دي F تربيع على اتنين ال A عبارة
+
+327
+00:41:34,240 --> 00:41:46,660
+عن باي على اربعة دي تربيع في G DX حسين
+
+328
+00:41:46,660 --> 00:41:47,540
+ان دي واحد
+
+329
+00:41:51,430 --> 00:42:04,710
+one point واحد في اتنين F square على by D تربيع في
+
+330
+00:42:04,710 --> 00:42:10,970
+G في L معناه
+
+331
+00:42:10,970 --> 00:42:13,710
+ال total strain energy هتكون U transverse shear
+
+332
+00:42:13,710 --> 00:42:19,270
+stress زي U bending moment هتكون تساوي اللي هي
+
+333
+00:42:19,270 --> 00:42:27,910
+حجمه اتنيناتنين point اتنين اتنين F تربيع L على
+
+334
+00:42:27,910 --> 00:42:37,490
+باي D تربيع G زاد U depending moment اتنين و
+
+335
+00:42:37,490 --> 00:42:51,630
+تلاتين F square التكيب على تلاتة
+
+336
+00:42:58,820 --> 00:43:11,600
+E by D أربعة يعني لو بدنا نبسط أكتر شوية أخدنا F
+
+337
+00:43:11,600 --> 00:43:21,380
+square L على by D تربيع F square L على by D تربيع
+
+338
+00:43:21,380 --> 00:43:25,680
+بالسيراندي اتنين
+
+339
+00:43:27,420 --> 00:43:38,980
+بونت اتنين اتنين على جي زائد اتنين و تلاتين
+
+340
+00:43:38,980 --> 00:43:42,140
+التربية
+
+341
+00:43:42,140 --> 00:43:45,340
+على
+
+342
+00:43:45,340 --> 00:43:48,980
+تلاتة
+
+343
+00:43:48,980 --> 00:43:51,880
+ا دي تربية
+
+344
+00:43:57,630 --> 00:44:03,050
+هيك يكون وجدنا total strain energy due to both
+
+345
+00:44:03,050 --> 00:44:08,050
+اللي هو transverse shear loading و bending loading
+
+346
+00:44:08,050 --> 00:44:14,770
+المحاضرة الجاي بنكمل
+
+347
+00:44:14,770 --> 00:44:17,990
+في ال strain energy بس هندرس اشي اسمه Castellano
+
+348
+00:44:17,990 --> 00:44:22,630
+theorem عشان نوجد deflection عند أي موقع في .. في
+
+349
+00:44:22,630 --> 00:44:25,370
+.. في beam تحت أثير أحمل
+
diff --git a/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/BTYGbzBT3fw_postprocess.srt b/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/BTYGbzBT3fw_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..6311ee95cf7a91d3328c9c9397f9fad84a3b48fd
--- /dev/null
+++ b/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/BTYGbzBT3fw_postprocess.srt
@@ -0,0 +1,2256 @@
+1
+00:00:04,890 --> 00:00:07,550
+بسم الله الرحمن الرحيم السلام عليكم و رحمة الله و
+
+2
+00:00:07,550 --> 00:00:11,870
+بركاته عودة
+
+3
+00:00:11,870 --> 00:00:16,330
+انقلت إلى مادة تصميم الألات واحد احنا بدأنا ب
+
+4
+00:00:16,330 --> 00:00:19,090
+chapter أربعة .. chapter أربعة كان يحكي على ال
+
+5
+00:00:19,090 --> 00:00:21,570
+deflection and stiffness analysis of mechanical
+
+6
+00:00:21,570 --> 00:00:26,930
+membersحنرجع المحاضرة السابقة المحاضرة السابقة we
+
+7
+00:00:26,930 --> 00:00:30,550
+define the strain energy due to forces acting on a
+
+8
+00:00:30,550 --> 00:00:35,030
+mechanical part as U بستو F square على اتنين K ال
+
+9
+00:00:35,030 --> 00:00:40,470
+F اللي هي ال applied force ال K ال stiffness of
+
+10
+00:00:40,470 --> 00:00:44,790
+the mechanical part طبعا ال strain energy كانت
+
+11
+00:00:44,790 --> 00:00:49,630
+تعتمدحالة نوعية ال loading في حالة axial loading
+
+12
+00:00:49,630 --> 00:00:53,990
+سواء كان tension او compression ال formula لل
+
+13
+00:00:53,990 --> 00:00:59,870
+strain energy كانت تكامل لل F² dx على 2 AE ال F هي
+
+14
+00:00:59,870 --> 00:01:03,530
+axial force ال A ال cross section ال area للمنبر
+
+15
+00:01:03,530 --> 00:01:06,690
+ال E ال modulus of elasticity وDx اللي هي
+
+16
+00:01:06,690 --> 00:01:11,090
+displacement بالنسبة
+
+17
+00:01:11,090 --> 00:01:14,030
+لل strain energy ل torsional loading condition
+
+18
+00:01:14,030 --> 00:01:18,860
+كانتis given by this equation U بساوية تكمل T
+
+19
+00:01:18,860 --> 00:01:23,940
+squared على اتنين G J DX ال T اللي هي ال applied
+
+20
+00:01:23,940 --> 00:01:27,960
+torque ال G اللي هي ال modulus of rigidity او ال
+
+21
+00:01:27,960 --> 00:01:34,400
+shear modulus وال J ال polar moment of inertia في
+
+22
+00:01:34,400 --> 00:01:39,750
+حالة direct shear loadingالـ Strain Energy is
+
+23
+00:01:39,750 --> 00:01:45,650
+given by تكامل F² على اتنين A E A A G D X برضه ال
+
+24
+00:01:45,650 --> 00:01:48,990
+F هي ال shear force ال A هي ال cross sectional
+
+25
+00:01:48,990 --> 00:01:51,750
+area الجي الموديلوس of الrigidity او ال shear
+
+26
+00:01:51,750 --> 00:01:59,390
+modulusفي حالة bending loading ال energy is given
+
+27
+00:01:59,390 --> 00:02:05,610
+by the formula U بستوى تكامل M square على 2EIDX ال
+
+28
+00:02:05,610 --> 00:02:08,710
+M هي bending moment at the cross section ال E
+
+29
+00:02:08,710 --> 00:02:14,370
+موديلوس بلاسيسيتي ال I موديلوس cross sectional
+
+30
+00:02:14,370 --> 00:02:20,160
+moment of inertiaفي حالة Transverse Shear Loading
+
+31
+00:02:20,160 --> 00:02:23,020
+وين فيه عندنا bending بيكون عندنا Transverse Shear
+
+32
+00:02:23,020 --> 00:02:25,360
+Loading ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+33
+00:02:25,360 --> 00:02:25,720
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+34
+00:02:25,720 --> 00:02:26,940
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+35
+00:02:26,940 --> 00:02:27,160
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+36
+00:02:27,160 --> 00:02:27,860
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+37
+00:02:27,860 --> 00:02:29,560
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+38
+00:02:29,560 --> 00:02:35,520
+ال ال ال
+
+39
+00:02:35,520 --> 00:02:35,540
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+40
+00:02:35,540 --> 00:02:35,580
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+41
+00:02:35,580 --> 00:02:37,800
+ال ال ال ال ال ال ال ال ال
+
+42
+00:02:45,730 --> 00:02:49,890
+مستطيل مدور or any other cross section تابل أربع
+
+43
+00:02:49,890 --> 00:02:54,770
+واحد بيعطينا قيم ال C for different cross sections
+
+44
+00:02:54,770 --> 00:03:00,130
+في حالة مقطع مستطيل ال C كانت 1.2 في حالة مقطع
+
+45
+00:03:00,130 --> 00:03:09,970
+مدور ال C 1.11 حلين example أربع تمانيةأو جدن
+
+46
+00:03:09,970 --> 00:03:14,790
+دفلكشن عند ال force F باستخدام ال strength energy
+
+47
+00:03:14,790 --> 00:03:20,630
+method هذا آخر الشيء اللي وصلناه اليوم هنكمل اللي
+
+48
+00:03:20,630 --> 00:03:26,150
+هو Castellano theorem Castellano theorem تحكي
+
+49
+00:03:26,150 --> 00:03:30,270
+التالي forces act on anelastic systems subject أو
+
+50
+00:03:30,270 --> 00:03:34,830
+أولش ال Castellano theorem ال application بتاعتها
+
+51
+00:03:34,830 --> 00:03:40,430
+applies only for forcesacting on mechanical
+
+52
+00:03:40,430 --> 00:03:44,510
+elements subjected to small displacements يعني إذا
+
+53
+00:03:44,510 --> 00:03:48,030
+كانت ال displacement كبيرة Castellano theorem is
+
+54
+00:03:48,030 --> 00:03:51,990
+not valid يعني we apply Castellano theorem in case
+
+55
+00:03:51,990 --> 00:03:56,570
+of forces acting on mechanical elements with small
+
+56
+00:03:56,570 --> 00:04:01,770
+displacement الآن
+
+57
+00:04:01,770 --> 00:04:05,350
+according to Castellano displacement
+
+58
+00:04:07,200 --> 00:04:11,620
+corresponding to any force along its direction لو
+
+59
+00:04:11,620 --> 00:04:19,180
+عندي mechanical element طبعا
+
+60
+00:04:19,180 --> 00:04:28,200
+نتيجة ال loading حاسيبي عندي إيش؟ deflection هذا
+
+61
+00:04:28,200 --> 00:04:33,360
+ال force F هذا كانت liver beam according to
+
+62
+00:04:33,360 --> 00:04:37,930
+Castellano ال displacement Deltais given by ال
+
+63
+00:04:37,930 --> 00:04:41,930
+partial differential لل total strain energy
+
+64
+00:04:41,930 --> 00:04:49,090
+بالنسبة لل force F يعني displacement Delta بيساوي
+
+65
+00:04:49,090 --> 00:04:54,670
+ال partial derivative لل total strain energy with
+
+66
+00:04:54,670 --> 00:04:59,730
+respect to the force F هذا في حالة force في حالة
+
+67
+00:04:59,730 --> 00:05:05,170
+rotationروتيشنال ديسبلسمنت الـθيتا بساوية دي يو
+
+68
+00:05:05,170 --> 00:05:23,110
+باي دي ام خليني
+
+69
+00:05:23,110 --> 00:05:27,250
+احل مثال ان شوف كيف ممكن استخدم الcastellano
+
+70
+00:05:27,250 --> 00:05:31,590
+theorem نفس ال example السابق
+
+71
+00:05:34,380 --> 00:05:38,360
+the cantilever shown في عندى cantilever مثبت من
+
+72
+00:05:38,360 --> 00:05:44,740
+الطرف هذا is a carbon steel bar عبارة عن بار مصنوع
+
+73
+00:05:44,740 --> 00:05:53,120
+من الحديد الكربوني ten inch long طوله
+
+74
+00:05:53,120 --> 00:05:57,820
+ال مستوى
+
+75
+00:05:57,820 --> 00:05:59,680
+ten inch long
+
+76
+00:06:02,460 --> 00:06:08,620
+والقطر بتاع المقطع مدور بسوا
+
+77
+00:06:08,620 --> 00:06:27,100
+واحد انش ومدور بفرصة F بسوا
+
+78
+00:06:27,100 --> 00:06:27,940
+ميت باوند
+
+79
+00:06:34,160 --> 00:06:39,480
+Find maximum deflection using
+
+80
+00:06:39,480 --> 00:06:43,440
+Castellano theorem including that due to shear
+
+81
+00:06:43,440 --> 00:06:57,700
+اوجد ال maximum deflection بده y max ال
+
+82
+00:06:57,700 --> 00:07:02,100
+y هتكون الساوية du
+
+83
+00:07:04,120 --> 00:07:12,920
+أو partial by
+
+84
+00:07:12,920 --> 00:07:18,800
+DF ال
+
+85
+00:07:18,800 --> 00:07:26,540
+U هتكون مكونة من two components U هتكون strain
+
+86
+00:07:26,540 --> 00:07:34,860
+energy due to bending زي Udue to transverse shear
+
+87
+00:07:34,860 --> 00:07:42,220
+U S لو
+
+88
+00:07:42,220 --> 00:07:50,740
+أخدت section هنا على بعد X طلعت
+
+89
+00:07:50,740 --> 00:07:59,040
+أخدت free body diagram هاي ال force F هذه المسافة
+
+90
+00:07:59,040 --> 00:08:00,980
+X
+
+91
+00:08:02,860 --> 00:08:08,660
+فى عندى force F فى
+
+92
+00:08:08,660 --> 00:08:16,320
+عندى moment M أو
+
+93
+00:08:16,320 --> 00:08:17,860
+V
+
+94
+00:08:22,820 --> 00:08:28,020
+طبعا هكون عند ال .. ال .. ال .. ال .. ال V قيمتها
+
+95
+00:08:28,020 --> 00:08:44,800
+هتكون تساوي F و ال M هتكون بتساوي F X الان
+
+96
+00:08:44,800 --> 00:08:49,040
+ال U due to bending نرجع للمعادلات .. للمعادلات
+
+97
+00:08:49,040 --> 00:08:51,600
+السابقة ال U due to bending U
+
+98
+00:08:55,140 --> 00:09:08,520
+بتساوي تكامل M squared على 2EI في DX هتساوي
+
+99
+00:09:08,520 --> 00:09:20,000
+تكامل طبعا هي متكامل من 0 لأقل ال M عنده اللي هي F
+
+100
+00:09:20,000 --> 00:09:31,890
+X الكل تربيععلى اتنين EI DX من سفر لأقل بتساوي
+
+101
+00:09:31,890 --> 00:09:40,910
+طبعا عندي ال F is constant فحسي عندي F square على
+
+102
+00:09:40,910 --> 00:09:54,050
+اتنين EI تكامل X square DX من سفر لأقلهتساوي تكوين
+
+103
+00:09:54,050 --> 00:10:05,770
+X² X تكييب على تلاتة يعني هذه هتصير F² L تكييب على
+
+104
+00:10:05,770 --> 00:10:17,690
+6EI ال
+
+105
+00:10:17,690 --> 00:10:19,530
+U due to shear
+
+106
+00:10:25,570 --> 00:10:32,790
+transfer share هي تكامل C
+
+107
+00:10:32,790 --> 00:10:47,690
+V square على 2 A G من 0 لL هي الساوى تكامل ال C
+
+108
+00:10:47,690 --> 00:10:53,870
+constant ال C في الحالة هادة لمقطع مضور من الجدول
+
+109
+00:10:55,880 --> 00:11:05,000
+للمقطع المدور C بساوية واحد point واحد واحد هتكون
+
+110
+00:11:05,000 --> 00:11:18,240
+C F square على اتنين A G DX طبعا
+
+111
+00:11:18,240 --> 00:11:23,940
+انا عند ال C و ال F و ال A و ال G ثوابت من 0 ل L
+
+112
+00:11:25,710 --> 00:11:34,390
+معناته التكوينة ستكون C F²
+
+113
+00:11:34,390 --> 00:11:38,590
+L 2A
+
+114
+00:11:38,590 --> 00:11:46,910
+G يعني
+
+115
+00:11:46,910 --> 00:11:54,710
+انا اقول ان الـ Deflection Y بالساوية DUby DF
+
+116
+00:11:54,710 --> 00:12:06,190
+بتساوي DU due to pending by DF زي DU due to share
+
+117
+00:12:06,190 --> 00:12:18,490
+by DF احنا هنا ممكن نعرف اللي
+
+118
+00:12:18,490 --> 00:12:19,770
+هو DU pending
+
+119
+00:12:23,530 --> 00:12:32,970
+by DF هتكون الساوية اتنين F التكييب على ستة AI
+
+120
+00:12:32,970 --> 00:12:45,310
+يعني هتساوية F التكييب على تلاتة AI وDUS
+
+121
+00:12:45,310 --> 00:12:51,370
+by DF بساوية اتنين C
+
+122
+00:12:53,310 --> 00:13:07,250
+F L على اتنين A G يعني أنا هستقل C F L على A G
+
+123
+00:13:07,250 --> 00:13:13,530
+يعني
+
+124
+00:13:13,530 --> 00:13:21,250
+انا ممكن احكي Y هيبقى على مؤكونين Y due to bending
+
+125
+00:13:22,520 --> 00:13:32,480
+z y due to share ال y due to bending ال
+
+126
+00:13:32,480 --> 00:13:45,580
+هي du bending by df بتساوي لأفقال تكيب على
+
+127
+00:13:45,580 --> 00:13:49,120
+تلاتة ei
+
+128
+00:13:59,950 --> 00:14:05,430
+خلّيني أحسب بعض الشغلات هنا أنا
+
+129
+00:14:05,430 --> 00:14:10,470
+بدي أحسب المقطع المدور ال A بالساوية باي على أربعة
+
+130
+00:14:10,470 --> 00:14:17,890
+دي تربيع يعني باي على أربعة في واحد تربيع بالساوية
+
+131
+00:14:17,890 --> 00:14:26,010
+باي على أربعة هذه ال area و ال I بالساوية باي على
+
+132
+00:14:26,010 --> 00:14:31,500
+أربعة و ستين دي بس أربعةيعني هيكون باي على اربعة و
+
+133
+00:14:31,500 --> 00:14:44,840
+ستين في واحد تربيع يعني باي على اربعة و ستين ال
+
+134
+00:14:44,840 --> 00:14:51,160
+E من الجداول ال E لل carbon steel بيساوي تلاتين
+
+135
+00:14:51,160 --> 00:15:01,620
+ميجا باوند per square inch وال Gبساوي احداش و نص
+
+136
+00:15:01,620 --> 00:15:10,620
+جيجاباوند per square inch او
+
+137
+00:15:10,620 --> 00:15:20,940
+ميجاباوند per square
+
+138
+00:15:20,940 --> 00:15:25,120
+inch يعني
+
+139
+00:15:25,120 --> 00:15:27,240
+ال why due to pending هتكون
+
+140
+00:15:29,740 --> 00:15:39,460
+اللف عندي أكم؟ معطني أمية وال L عشرة في عشرة تكيب
+
+141
+00:15:39,460 --> 00:15:57,040
+على تلاتة ال E في تلاتين في عشرة أقل ستة في ال I
+
+142
+00:15:57,040 --> 00:16:05,330
+اللي هي بايعلى اربعة و ستين و بنحسب ال Y due to
+
+143
+00:16:05,330 --> 00:16:09,970
+pending ال
+
+144
+00:16:09,970 --> 00:16:16,590
+Y due to share اللي
+
+145
+00:16:16,590 --> 00:16:24,190
+هي هتكون DUS by DF نعملها بالساعة والسي
+
+146
+00:16:26,850 --> 00:16:36,870
+F L على A في G ال C واحد point واحد واحد ال F مية
+
+147
+00:16:36,870 --> 00:16:46,990
+وال L عشرة وال A باي على أربع باي على أربع وال G
+
+148
+00:16:46,990 --> 00:16:53,590
+خلينا نتاكد ال G للحديد أحداشر نص ميجا
+
+149
+00:16:59,160 --> 00:17:00,360
+هنفتح الجداول
+
+150
+00:17:33,200 --> 00:17:40,760
+اللي هو A5 عندنا هيكون ال
+
+151
+00:17:40,760 --> 00:17:48,500
+carbon steel ال ال G 11.5 ميجا باوند per square
+
+152
+00:17:48,500 --> 00:17:55,440
+inch وال A30 صحيح طيب
+
+153
+00:17:55,440 --> 00:17:57,640
+ال G 11.5
+
+154
+00:18:01,300 --> 00:18:11,160
+في عشرة في الستة و بنحسبها لو
+
+155
+00:18:11,160 --> 00:18:21,480
+حسبنا ال why due to pending هيكون عنده
+
+156
+00:18:21,480 --> 00:18:25,160
+مية
+
+157
+00:18:25,160 --> 00:18:36,440
+في الف في اربعة و ستينعلى تسعين
+
+158
+00:18:36,440 --> 00:18:51,200
+على أشهر و ستة بيطلع
+
+159
+00:18:51,200 --> 00:18:57,780
+عندى point او اتنين اتنين ستة point او اتنين اتنين
+
+160
+00:18:57,780 --> 00:19:02,850
+ستةالـ why do you cheer لحالها
+
+161
+00:19:34,040 --> 00:19:42,600
+بيطلع point o o واحد من عشر تلاف point o o واحد
+
+162
+00:19:42,600 --> 00:19:49,580
+انش معناه ال total deflection y هيكون مجموعهم
+
+163
+00:19:49,580 --> 00:19:59,700
+point o اتنين اتنين ستة زي point o o o واحد يعني
+
+164
+00:19:59,700 --> 00:20:09,400
+هيكون point oاتنين اتنين سبعة انش
+
+165
+00:20:42,930 --> 00:20:48,330
+طيب هذا المطلوب التاني what error is introduced if
+
+166
+00:20:48,330 --> 00:20:51,030
+shear is neglected إذا أهملت الشير يعني اعتبرت
+
+167
+00:20:51,030 --> 00:21:02,290
+الشير مهمل يعني لو حكيت if shear is
+
+168
+00:21:02,290 --> 00:21:06,650
+neglected هكون
+
+169
+00:21:06,650 --> 00:21:14,510
+ال y هي ال y بتاعة ال bendingبس تقريبا بتساوي اللي
+
+170
+00:21:14,510 --> 00:21:24,110
+هي point o اتنين اتنين ست انش لو لان نحصل
+
+171
+00:21:24,110 --> 00:21:32,110
+percentage error due to ignorance of shear هيكون
+
+172
+00:21:32,110 --> 00:21:39,130
+ساوي اللي هو point o اتنين اتنين سبعة minus point
+
+173
+00:21:39,130 --> 00:21:54,080
+o2 2 6 على point o 227 في 100 يعني
+
+174
+00:21:54,080 --> 00:21:54,580
+هيكون
+
+175
+00:22:30,440 --> 00:22:37,340
+بطلع نسبة الخطأ point 4 4 بالمية point 4 4 percent
+
+176
+00:22:37,340 --> 00:22:43,160
+معناته ال .. اذا في معظم الأحيان اذا كان موجود
+
+177
+00:22:43,160 --> 00:22:47,540
+عندي bending و transverse shear ال deflection due
+
+178
+00:22:47,540 --> 00:22:53,700
+to transverse shear صغير جدا بالمقارنة مع ال .. ال
+
+179
+00:22:53,700 --> 00:22:58,040
+deflection due to bending و الدليل لما حسبنا هنا
+
+180
+00:22:58,040 --> 00:23:03,810
+طلعت الخطأفي ال .. في الإجابة bond for 4% إذا
+
+181
+00:23:03,810 --> 00:23:09,110
+أهملت ال .. إيش؟ ال sheer effect وبتاع بشكل عام
+
+182
+00:23:09,110 --> 00:23:12,990
+احنا ممكن نهمل ال sheer effect لإنه is not
+
+183
+00:23:12,990 --> 00:23:20,170
+significant ليس دو قيمة نكمل
+
+184
+00:23:20,170 --> 00:23:20,810
+طيب
+
+185
+00:23:45,440 --> 00:23:50,380
+أحنا حكيها من الشروط بتاعة Castellano عشان أحس ب
+
+186
+00:23:50,380 --> 00:23:55,360
+deflection at any location لازم تكون اتأثر force
+
+187
+00:23:55,360 --> 00:23:57,840
+عند ال location تحت الدراسة يعني لو أنا هي عندي
+
+188
+00:23:57,840 --> 00:24:05,890
+cantilever وفي عنديforce F بدي أحسب النقطة هذه في
+
+189
+00:24:05,890 --> 00:24:11,430
+force F بتأثر طيب إذا بدي أحسب النقطة هذه مافيش
+
+190
+00:24:11,430 --> 00:24:20,730
+force F اللي بقى أسوي إنه بحط قوة خيالية بسميها
+
+191
+00:24:20,730 --> 00:24:29,920
+اكيو و بحسبالـ total strain energy كما لو كانت Q
+
+192
+00:24:29,920 --> 00:24:39,200
+موجودة طبعا F موجودة بعدين بحسب Delta سواء Du by
+
+193
+00:24:39,200 --> 00:24:45,760
+DQ بعدين بحط Q بالساوية سفر لأنه مش موجود أصلا
+
+194
+00:24:45,760 --> 00:24:51,430
+يعنيفمعناته من مستلزمات Castellano's theorem إذا
+
+195
+00:24:51,430 --> 00:24:55,610
+أنا بدي أحسب ال deflection at any location لازم
+
+196
+00:24:55,610 --> 00:24:58,250
+يكون فيه عندى قوة أثر باتجاه ال deflection المطلوب
+
+197
+00:24:58,250 --> 00:25:02,410
+حسابهوبالتالي إذا مش موجود ال force هذا بدي أحط
+
+198
+00:25:02,410 --> 00:25:06,790
+قوة تخيلية Q بحسب ال total external energy given
+
+199
+00:25:06,790 --> 00:25:12,250
+يعني بوجود Q ووجود F بعدين بحسب ال Delta سوى Du by
+
+200
+00:25:12,250 --> 00:25:16,890
+DQ بعد ما أحكي ال Delta سوى Du by DQ بحط Q بساوية
+
+201
+00:25:16,890 --> 00:25:22,190
+0 يعني طريقة تحيل .. تحيلنا على ال theorem و بعدين
+
+202
+00:25:22,190 --> 00:25:25,310
+في الآخر صفرنا ال Q اللي هي ال .. ال Q الخيالية
+
+203
+00:25:35,690 --> 00:25:42,370
+أحنا لما كنا نحسب ال total strain energy لما كنا
+
+204
+00:25:42,370 --> 00:25:45,930
+نحسب ال total strain energy مثلا لو أخدنا على سبيل
+
+205
+00:25:45,930 --> 00:25:51,410
+المثال ال building كنا
+
+206
+00:25:51,410 --> 00:25:55,830
+نحكي ال U بالساعة
+
+207
+00:25:55,830 --> 00:26:03,810
+التكامل M² على 2EI dx
+
+208
+00:26:05,440 --> 00:26:11,100
+لحظوا انا لما احسب ال M و تكون function of X و
+
+209
+00:26:11,100 --> 00:26:15,640
+اربعها بصير عندي ال integral يعني معقد و في الأخر
+
+210
+00:26:15,640 --> 00:26:20,040
+انا في الأخر هعمل partial derivative لكن لو روح
+
+211
+00:26:20,040 --> 00:26:28,680
+ادخلت ال partial حكيت ال delta بيستوى Du by Df
+
+212
+00:26:28,680 --> 00:26:40,650
+يعني هيكون D by Dfلتكامل M2 على 2EI DX ودخلت الـ
+
+213
+00:26:40,650 --> 00:26:49,970
+differential لجوة حسينا دي تكامل 1 على 2EI D by DF
+
+214
+00:26:49,970 --> 00:27:01,940
+ل M2 DX حسينا دي 1 على 2EIDifferential M with
+
+215
+00:27:01,940 --> 00:27:13,660
+respect to F هتكون M هتكون اتنين M في DM by DF DX
+
+216
+00:27:13,660 --> 00:27:27,300
+اتنين مع اتنين بتصفه سوى واحد على EI في M DM by DF
+
+217
+00:27:27,300 --> 00:27:35,630
+DXDX يعني انا ممكن ادخل ال differential جوا
+
+218
+00:27:35,630 --> 00:27:38,370
+ال integral هذا بسهل كتير الشغل بسهل ال
+
+219
+00:27:38,370 --> 00:27:43,190
+integration بشكل كبير جدا لان already انا ماخدت ال
+
+220
+00:27:43,190 --> 00:27:47,730
+differential of M with respect to the force اللي
+
+221
+00:27:47,730 --> 00:27:54,110
+عندها ال deflection بنفس الملهجية اذا كان عندى
+
+222
+00:27:54,110 --> 00:27:58,840
+only tensionبدخل الـ differential جوا بيصير ان الـ
+
+223
+00:27:58,840 --> 00:28:03,060
+delta I ال location I بيصيح واحدة على AE في FDF by
+
+224
+00:28:03,060 --> 00:28:09,840
+DFI DX و theta I due to bending واحدة على GJ في
+
+225
+00:28:09,840 --> 00:28:14,360
+TDT
+
+226
+00:28:14,360 --> 00:28:21,480
+by DMI و delta I due to bending هتكون واحدة دي I
+
+227
+00:28:21,480 --> 00:28:23,700
+في MDM by DFI في DX
+
+228
+00:28:28,190 --> 00:28:46,910
+تشوف مثال تاني تشوف
+
+229
+00:28:46,910 --> 00:28:51,650
+مثال تاني using
+
+230
+00:28:51,650 --> 00:28:56,010
+Castellanos method باستخدام طريقة Castellanos
+
+231
+00:28:57,700 --> 00:29:03,340
+determine deflections of points A and B نقطة A
+
+232
+00:29:03,340 --> 00:29:11,360
+ونقطة B نقطة A ونقطة
+
+233
+00:29:11,360 --> 00:29:21,480
+B due to the force F نقطة F نقطة F نقطة F نقطة F
+
+234
+00:29:21,480 --> 00:29:24,940
+نقطة F نقطة F نقطة F نقطة
+
+235
+00:29:27,670 --> 00:29:33,110
+الموقعات الثانية للمقاطع A B وهذا مقاطع A B وهذا
+
+236
+00:29:33,110 --> 00:29:39,730
+مقاطع B C R
+
+237
+00:29:39,730 --> 00:29:46,710
+I واحد واتنين
+
+238
+00:29:46,710 --> 00:29:50,630
+I واحد respectively
+
+239
+00:29:52,220 --> 00:29:56,240
+بيده deflection عند a و deflection عند b لان خيانه
+
+240
+00:29:56,240 --> 00:30:03,040
+find deflection at a find deflection
+
+241
+00:30:03,040 --> 00:30:07,180
+at
+
+242
+00:30:07,180 --> 00:30:12,160
+a اول
+
+243
+00:30:12,160 --> 00:30:18,460
+شي اللحظه ان المقطع مش منتظم المقطع عند في الجزء
+
+244
+00:30:18,460 --> 00:30:23,320
+الاول يعني من a لbمختلف عن المقطع في الجزء من B لC
+
+245
+00:30:23,320 --> 00:30:30,160
+I واحد هنا عند ال I للمقطع BC ضعف ال I للمقطع AB
+
+246
+00:30:30,160 --> 00:30:34,340
+احنا
+
+247
+00:30:34,340 --> 00:30:39,980
+في المثال السابق اثبتنا ان قيمة ال deflection due
+
+248
+00:30:39,980 --> 00:30:46,160
+to transverse shear is very small compared to that
+
+249
+00:30:46,160 --> 00:30:51,430
+due to bendingour assumption we neglect deflection
+
+250
+00:30:51,430 --> 00:30:59,010
+due to transverse shear معناته neglect اهمل
+
+251
+00:30:59,010 --> 00:31:06,470
+deflection due
+
+252
+00:31:06,470 --> 00:31:13,670
+to transverse shear
+
+253
+00:31:13,670 --> 00:31:16,310
+هاي أول assumption
+
+254
+00:31:19,160 --> 00:31:26,460
+عندي هاي ال X Axis و
+
+255
+00:31:26,460 --> 00:31:32,280
+هاي ال Y Axis الان
+
+256
+00:31:32,280 --> 00:31:39,960
+at any given section على بعد X هاخد free body
+
+257
+00:31:39,960 --> 00:31:46,300
+diagram هاي
+
+258
+00:31:46,300 --> 00:31:47,200
+ال force F
+
+259
+00:31:50,470 --> 00:32:01,710
+عدي المسافة X هنا هكون في عنده F هكون في عنده
+
+260
+00:32:01,710 --> 00:32:06,270
+moment M لاحظوا
+
+261
+00:32:06,270 --> 00:32:09,190
+لما أنا مش هاهتم في إشارتها negative ولا positive
+
+262
+00:32:09,190 --> 00:32:13,090
+لأنه في الآخر هضرب two terms negative مع negative
+
+263
+00:32:13,090 --> 00:32:18,610
+إيش هيعطيلي positive وبالتالي مش هيأثر كتير أو مش
+
+264
+00:32:18,610 --> 00:32:29,510
+هيأثرالإشارة على الحل عند ال moment هتكون بستوي
+
+265
+00:32:29,510 --> 00:32:34,790
+F X I
+
+266
+00:32:34,790 --> 00:32:42,370
+have only bending معناته ال delta عند A هتكون
+
+267
+00:32:42,370 --> 00:32:42,870
+بستوي
+
+268
+00:32:49,010 --> 00:32:52,370
+طالبا انا عندي ال two sections مختلفين عن بعض
+
+269
+00:32:52,370 --> 00:32:57,710
+بيبقى جزء ال مثل الجزءين جزء a,b زاد الجزء b,c
+
+270
+00:32:57,710 --> 00:33:11,050
+وانا عندي I have only bending هتكون delta a هتكون
+
+271
+00:33:11,050 --> 00:33:16,410
+تساوي تكامل
+
+272
+00:33:18,840 --> 00:33:24,220
+واحد على EI ل
+
+273
+00:33:24,220 --> 00:33:37,080
+M DM by DF DX طبعا
+
+274
+00:33:37,080 --> 00:33:42,900
+عندي two terms او عندي two sections واحد على EI
+
+275
+00:33:42,900 --> 00:33:46,480
+واحد من سفر ل L على اتنين
+
+276
+00:33:49,740 --> 00:33:59,780
+زائد واحد على E احنا حكينا I2 اتنين
+
+277
+00:33:59,780 --> 00:34:03,740
+I واحد زائد
+
+278
+00:34:03,740 --> 00:34:09,540
+واحد على E I اتنين اللي هي عبارة عن اتنين I واحد
+
+279
+00:34:09,540 --> 00:34:12,640
+في
+
+280
+00:34:12,640 --> 00:34:13,640
+M
+
+281
+00:34:19,240 --> 00:34:30,700
+DM by DF DX ال X تغير من L على 2 ل L انا رودي عند
+
+282
+00:34:30,700 --> 00:34:44,020
+ال F بالساوية FX ال M معناته
+
+283
+00:34:44,020 --> 00:34:54,330
+DMو بعدين F هتكون تساوياش X يعني
+
+284
+00:34:54,330 --> 00:35:05,190
+Delta A هتكون تساوي تكامل من 0 ل L على 2 1 على E I
+
+285
+00:35:05,190 --> 00:35:22,610
+1 ال M عندى عبارة عن F Xو DMYDF F X DX زاد التكامل
+
+286
+00:35:22,610 --> 00:35:40,770
+من L على 2 ل L 1 على 2 E I 1 M F X F X DX حيساوى
+
+287
+00:35:40,770 --> 00:35:51,950
+حيطلع عني طبعا برا اللي هوF على E I واحد تكامل
+
+288
+00:35:51,950 --> 00:36:01,770
+من صفر ل L على اتنين ل X تربيع DX زائد واحد على
+
+289
+00:36:01,770 --> 00:36:03,650
+اتنين E I واحد
+
+290
+00:36:06,900 --> 00:36:16,780
+فى F طبعا تكامل من L على 2 لL ل X تربيع DX حيث
+
+291
+00:36:16,780 --> 00:36:22,180
+ساوى طبعا أول تكامل هيكون قيمته هصيرها DX تكييب
+
+292
+00:36:22,180 --> 00:36:32,560
+على 3 من 0 لL على 2 يعني هيكون عندي F L
+
+293
+00:36:32,560 --> 00:36:41,110
+تكييبعلى اربع و عشرين اي
+
+294
+00:36:41,110 --> 00:36:45,990
+اي واحد زائد
+
+295
+00:36:45,990 --> 00:36:49,130
+اف
+
+296
+00:36:49,130 --> 00:36:59,390
+على اتنين اي اي واحد طبعا هنا ستة هيكون في
+
+297
+00:36:59,390 --> 00:37:03,210
+هيكون لتكييب
+
+298
+00:37:06,810 --> 00:37:16,390
+مينوس التى كيب على تمانية يعني
+
+299
+00:37:16,390 --> 00:37:25,670
+Delta A هتكون تستوى F التى كيب على اربع وعشرين E I
+
+300
+00:37:25,670 --> 00:37:32,150
+واحد زائد طبعا هنا التى كيب ناقص التى كيب على
+
+301
+00:37:32,150 --> 00:37:32,650
+تمانية
+
+302
+00:37:39,520 --> 00:37:45,440
+هتكون سبعة على تمانية تمانية بستة تمانية أربعين
+
+303
+00:37:45,440 --> 00:37:57,600
+على تمانية أربعين في
+
+304
+00:37:57,600 --> 00:37:58,020
+سبعة
+
+305
+00:38:06,440 --> 00:38:14,760
+يعنى deflection هكون ساوى هجمعهم عشرة او
+
+306
+00:38:14,760 --> 00:38:19,820
+تسعة هتكون
+
+307
+00:38:19,820 --> 00:38:28,620
+سبعة زائد اتنين سبعة زائد اتنين تسعة تسعة if ال
+
+308
+00:38:28,620 --> 00:38:38,700
+تكييب على التمانية و اربعينEI واحد يعني انا هيكون
+
+309
+00:38:38,700 --> 00:38:49,540
+عند ايه تلاتة F التكييب على ستاشر EI واحد هذه ال
+
+310
+00:38:49,540 --> 00:38:54,300
+deflection عند ايه طبعا
+
+311
+00:38:54,300 --> 00:39:01,680
+بتوقع منكم تتراجعوا الاحسابات هذه ورايااتأكدوا من
+
+312
+00:39:01,680 --> 00:39:10,080
+دقتها إذا في أي خطأ صححه طيب
+
+313
+00:39:10,080 --> 00:39:13,220
+هذا
+
+314
+00:39:13,220 --> 00:39:15,560
+المطلوب الأول المطلوب التاني بدحس ال deflection
+
+315
+00:39:15,560 --> 00:39:16,380
+عند B
+
+316
+00:39:30,580 --> 00:39:34,860
+الان عند B مافيش
+
+317
+00:39:34,860 --> 00:39:40,440
+force عشان أحسن deflection عند B لازم أحط force
+
+318
+00:39:40,440 --> 00:39:48,460
+تخيّلية بدي أحط force تخيّلية واسميها
+
+319
+00:39:48,460 --> 00:39:53,420
+H EQ معناته
+
+320
+00:39:53,420 --> 00:39:58,640
+ال deflection عند B دلتا B هيكون بساوة
+
+321
+00:40:01,310 --> 00:40:05,750
+اللي هو دلتا
+
+322
+00:40:05,750 --> 00:40:16,630
+عند بي سوى دي يو باي دي كيو We
+
+323
+00:40:16,630 --> 00:40:21,250
+have only bending و
+
+324
+00:40:21,250 --> 00:40:26,190
+أهملنا للtransverse shear رقم واحد رقم اتنين
+
+325
+00:40:28,800 --> 00:40:35,500
+لازم انقسم ال beam ل two parts لسببين أول السبب
+
+326
+00:40:35,500 --> 00:40:39,380
+الأول انه انا عندي ال section في ال a,b مساحة
+
+327
+00:40:39,380 --> 00:40:42,760
+المقطع مختلفة عن مساحة المقطع في ال section ب,c
+
+328
+00:40:42,760 --> 00:40:49,940
+سبب تاني صار في عندي كمان قوة مركزة تخيلوا ليها Q
+
+329
+00:40:49,940 --> 00:40:51,120
+عند نقطة B
+
+330
+00:41:01,080 --> 00:41:06,700
+معناته هاخد ال free body diagram في الفترة من a ل
+
+331
+00:41:06,700 --> 00:41:16,860
+b يعني هاخد أول شي section هي section على بعد X لو
+
+332
+00:41:16,860 --> 00:41:25,220
+أخد section على بعد X هي عندي false F وهذه المسافة
+
+333
+00:41:25,220 --> 00:41:29,540
+إيش X هيكون
+
+334
+00:41:29,540 --> 00:41:53,190
+عندي هنا Fوعندي M خصمها MAB MAB بتساوي FX
+
+335
+00:41:53,190 --> 00:41:58,090
+هاي الحالة لقول الحالة التانية هاخد section هنا
+
+336
+00:42:01,650 --> 00:42:09,630
+هذه هي ال X عندي اللي
+
+337
+00:42:09,630 --> 00:42:17,910
+هي ال section التاني هذه
+
+338
+00:42:17,910 --> 00:42:28,130
+A هذه B وعندي هنا F وعندي هنا Q وعندي هذه المسافة
+
+339
+00:42:28,130 --> 00:42:28,970
+أيهاش كلها X
+
+340
+00:42:33,140 --> 00:42:40,420
+هذه المسافة L على 2 هين
+
+341
+00:42:40,420 --> 00:42:46,820
+هيكون طبعا force V بتعكسهم وفي
+
+342
+00:42:46,820 --> 00:43:01,400
+bending moment M V C و M V C هتساوي F
+
+343
+00:43:01,400 --> 00:43:01,880
+X
+
+344
+00:43:09,900 --> 00:43:17,460
+زائد Q في
+
+345
+00:43:17,460 --> 00:43:26,900
+X ناقص L على اتنين هنا
+
+346
+00:43:26,900 --> 00:43:32,060
+لازم نحسب DMAB
+
+347
+00:43:32,060 --> 00:43:34,420
+BY DQ
+
+348
+00:43:37,610 --> 00:43:45,950
+0 لأن هذه F وهذه X هنا سأحسب DMBC
+
+349
+00:43:45,950 --> 00:43:56,570
+BY DQ هتكون سفر زائد X minus L على اتنين
+
+350
+00:44:10,710 --> 00:44:19,470
+I have only bending معناته delta B هتكون تساوي انا
+
+351
+00:44:19,470 --> 00:44:30,110
+هقسم لجزئين من A ل B و من B ل C تكامل من 0 ل L على
+
+352
+00:44:30,110 --> 00:44:37,630
+2 ل 1 على E ال section AB ال I تعته I واحد
+
+353
+00:44:41,260 --> 00:44:46,320
+في MAB DMAB
+
+354
+00:44:46,320 --> 00:45:01,000
+by DQ DX زائد التكامل من L على 2 لL في 1 على E ال
+
+355
+00:45:01,000 --> 00:45:05,000
+I بتاع ال section 2 عبارة عن 2EI 1
+
+356
+00:45:10,240 --> 00:45:23,420
+م بي سي دي ام بي سي بي دي كيو دي اكس
+
+357
+00:45:23,420 --> 00:45:27,980
+احنا already we find دي ام ا بي بي دي كيو بالساوة
+
+358
+00:45:27,980 --> 00:45:35,140
+صفر معناه الترم الأول هذا الترم كله
+
+359
+00:45:35,140 --> 00:45:45,930
+هذا بالساوة صفرمعنى انت هتصفح delta P بالساعة
+
+360
+00:45:45,930 --> 00:45:57,310
+واحدة تكامل من L على 2 ل L هطلع واحد على اتنين EI
+
+361
+00:45:57,310 --> 00:46:03,110
+واحد متعود عن MBC MBC عبارة عن FX
+
+362
+00:46:10,030 --> 00:46:23,210
+زاد Q في X minus L على 2 هذا ال MBC في DMBC by DQ
+
+363
+00:46:23,210 --> 00:46:31,810
+اللي هي X minus L على 2 في DX
+
+364
+00:46:36,220 --> 00:46:42,000
+الان set up كيو باسمها و سفر خل كيو هذه و حط كيو
+
+365
+00:46:42,000 --> 00:46:46,620
+باسمها و سفر احنا
+
+366
+00:46:46,620 --> 00:46:57,280
+اتحيلنا عليها بس هتصف هذه تكامل واحد
+
+367
+00:46:57,280 --> 00:47:10,490
+على اتنين E I واحد تكامل من ال على اتنينلL ل
+
+368
+00:47:10,490 --> 00:47:15,750
+FX في
+
+369
+00:47:15,750 --> 00:47:29,310
+X minus L على 2 DX يعني هتسير هطلع ال F برا ف F
+
+370
+00:47:29,310 --> 00:47:42,710
+على 2EI 1تكامل من L على 2 ل L هدخل X لجوه X تربيع
+
+371
+00:47:42,710 --> 00:48:01,070
+minus XL على 2 DX يعني هتكون F على 2 E I 1في تكامل
+
+372
+00:48:01,070 --> 00:48:11,230
+X تربيع عبارة عن إيش في X تكييب على تلاتة minus X
+
+373
+00:48:11,230 --> 00:48:20,130
+تربيع L على أربعة والتكامل حدوده من L على اتنين ل
+
+374
+00:48:20,130 --> 00:48:27,650
+L يعني هيكون يساوي F
+
+375
+00:48:29,210 --> 00:48:37,970
+على اتنين E I واحد في تلت
+
+376
+00:48:37,970 --> 00:48:41,830
+ال
+
+377
+00:48:41,830 --> 00:48:45,730
+تكييب minus
+
+378
+00:48:45,730 --> 00:48:53,130
+ال تكييب على تمانية minus
+
+379
+00:48:53,130 --> 00:49:04,110
+ال على اربعة في ال تربيعminus L تربيع على أربعة
+
+380
+00:49:04,110 --> 00:49:07,430
+يعني
+
+381
+00:49:07,430 --> 00:49:15,510
+هاخد L تكعيب برا ف L تكعيب على
+
+382
+00:49:15,510 --> 00:49:24,750
+اتنين E I واحد في هذا هتكون اندي تمانية او واحد
+
+383
+00:49:24,750 --> 00:49:28,770
+ناقص تمون سبعة على تمانية يعني هتكون اندي سبعة على
+
+384
+00:49:28,770 --> 00:49:29,750
+أربعة وعشرين
+
+385
+00:49:34,340 --> 00:49:45,160
+ناقص واحد ناقص ربع تلت اربعة تلت اربعة في ربع تلت
+
+386
+00:49:45,160 --> 00:49:53,200
+ع ستاش يعني
+
+387
+00:49:53,200 --> 00:49:57,280
+هيصف اربع و عشرين
+
+388
+00:50:00,010 --> 00:50:13,250
+يعني هيكون عندى fl تكييب على اتنين ei واحد في عندى
+
+389
+00:50:13,250 --> 00:50:17,690
+هيكون تمانية و اربعين تمانية و اربعين على اربع و
+
+390
+00:50:17,690 --> 00:50:26,130
+عشرين اتنين في سبعة اربعتاش ناقص تمانية و اربعين
+
+391
+00:50:26,130 --> 00:50:32,800
+على ستاشتلاتة تلاتة تلاتة تسعة اربتاش ناقص تسعة
+
+392
+00:50:32,800 --> 00:50:45,040
+اللي هي خمسة يعني هتصفي خمسة F L تكييب على ستة
+
+393
+00:50:45,040 --> 00:50:51,080
+وتسعين E I واحد
+
+394
+00:50:52,500 --> 00:50:58,780
+معناة deflection at B اللي هو F A لتا كيب على 96EI
+
+395
+00:50:58,780 --> 00:51:03,020
+اكيد ال deflection at B ارجع للحل قارنه بال
+
+396
+00:51:03,020 --> 00:51:17,800
+deflection at A اكيد عند B هيكون اقل من عند A طيب
+
+397
+00:51:17,800 --> 00:51:20,300
+نكمل
+
+398
+00:51:51,710 --> 00:51:59,810
+هنحل مسألة تانية اكثر تعقيدا فيها تفاصيل اكتر
+
+399
+00:51:59,810 --> 00:52:03,310
+for
+
+400
+00:52:03,310 --> 00:52:08,430
+the wire form of diameter D as shown في عند السلك
+
+401
+00:52:08,430 --> 00:52:14,810
+مشكل بالشكل هذا ومثبت عند الطرف G السلك اللي هو
+
+402
+00:52:14,810 --> 00:52:19,330
+BCDG
+
+403
+00:52:19,330 --> 00:52:26,060
+مثبت عند الطرف Gقطره دي small قطر السلك دي small
+
+404
+00:52:26,060 --> 00:52:30,220
+determine
+
+405
+00:52:30,220 --> 00:52:34,880
+the deflection of point B in the direction of the
+
+406
+00:52:34,880 --> 00:52:39,580
+applied force F أجرى ال deflection عن نقطة B في
+
+407
+00:52:39,580 --> 00:52:43,120
+اتجاه ال force F يعني في اتجاه هذا ال deflection
+
+408
+00:52:43,120 --> 00:52:46,420
+اللي بدى لو بدى ال deflection في هذا الاتجاه لازم
+
+409
+00:52:46,420 --> 00:52:49,540
+أحط force تخيليا Q طيب
+
+410
+00:52:52,670 --> 00:52:58,070
+معطيلي ملاحظة او اشارة بيحكي neglect the effect of
+
+411
+00:52:58,070 --> 00:53:02,470
+transverse shear اهمل تأثير لل transverse shear
+
+412
+00:53:02,470 --> 00:53:06,630
+احنا anyway لو هو ماحكاش كنا هنهمله لان ال effect
+
+413
+00:53:06,630 --> 00:53:11,430
+عه صغير بالمقارنة بال other loading conditions
+
+414
+00:53:11,430 --> 00:53:15,950
+اللي هي سواء كانت bending او axial او torsion
+
+415
+00:53:15,950 --> 00:53:23,030
+هيكون ال effect عه ليس ذو قيمةاللحظ و انا عندى
+
+416
+00:53:23,030 --> 00:53:29,110
+الان different sections يعني بي سي و سي دي و دي جي
+
+417
+00:53:29,110 --> 00:53:34,590
+تلاتة sections each section is loaded differently
+
+418
+00:53:34,590 --> 00:53:37,190
+يعني ال section بي سي ال loading بتاعه مختلف عن ال
+
+419
+00:53:37,190 --> 00:53:42,150
+loading ل سي دي مختلف عن ال loading ل دي جي عشانك
+
+420
+00:53:42,150 --> 00:53:48,010
+انا هجزق المثلة هاخد ل بي سي و سي دي و دي جي و
+
+421
+00:53:48,010 --> 00:53:51,680
+اجمعهمعشان كنت لازم اخد free pedagram for each
+
+422
+00:53:51,680 --> 00:53:58,020
+segment alone اولش هيكون عندى
+
+423
+00:53:58,020 --> 00:54:06,220
+هاخد ال .. اولش ال delta .. ال delta الكل هي delta
+
+424
+00:54:06,220 --> 00:54:18,060
+B هتكون سوى DU by DF ال
+
+425
+00:54:18,060 --> 00:54:26,200
+Uفي عندي ال U for section BC وفي ال U for section
+
+426
+00:54:26,200 --> 00:54:35,400
+CD وفي U for section DJ معناه
+
+427
+00:54:35,400 --> 00:54:49,140
+هتكون بتساوي DU for section BC by DFزائد DU for
+
+428
+00:54:49,140 --> 00:55:02,260
+section CD by DF زائد DU for section DJ by DF هاخد
+
+429
+00:55:02,260 --> 00:55:10,120
+كل واحد لحاله يعني انا ممكن اسمي هذه دلتا
+
+430
+00:55:10,120 --> 00:55:14,000
+واحد او اسميها delta BC
+
+431
+00:55:16,810 --> 00:55:26,570
+delta bc ودلتا cd ودلتا
+
+432
+00:55:26,570 --> 00:55:36,930
+dg لما
+
+433
+00:55:36,930 --> 00:55:42,750
+ناخد free pedagram ل بي سي لحظة انا ممكن انا ممكن
+
+434
+00:55:42,750 --> 00:55:48,240
+ا define xبالطريقة اللي انا بديها او بطريقة انا
+
+435
+00:55:48,240 --> 00:55:52,340
+بحبها لان في الاخر هعمل differential يعني انا عرفت
+
+436
+00:55:52,340 --> 00:55:57,240
+اي define هذه ال X وهي
+
+437
+00:55:57,240 --> 00:56:04,400
+عندى هنا F هنا اكيد هتعكسها force F وهذه هتعمل
+
+438
+00:56:04,400 --> 00:56:09,320
+bending moment يعني هكون عندى bending moment MBC
+
+439
+00:56:13,080 --> 00:56:28,480
+م بي سي بساوي F في X F في X معناه
+
+440
+00:56:28,480 --> 00:56:39,840
+دي م بي سي by دي F بساوي X و I have only bending
+
+441
+00:56:39,840 --> 00:56:57,200
+معناه دلتاBC بالساوية تكامل واحد على EI لل MBC DM
+
+442
+00:56:57,200 --> 00:57:03,900
+BC by DF في DX
+
+443
+00:57:09,940 --> 00:57:16,960
+و ال X دي X بتغيب من صفر ل إيه؟ من صفر ل إيه؟ يعني
+
+444
+00:57:16,960 --> 00:57:28,280
+هيساوي هعوض هطلع واحد على EI تكامل ال MBC FX و دي
+
+445
+00:57:28,280 --> 00:57:36,340
+MBC by DX اللي هي X هصيرها دي في X DX هيساوي هطلع
+
+446
+00:57:36,340 --> 00:57:38,660
+F على EI
+
+447
+00:57:42,410 --> 00:57:47,390
+هيبقى من صفر ل A تكمل X تربيع علي X تكييب على
+
+448
+00:57:47,390 --> 00:57:56,250
+تلاتة هتصير هذه ال H تكملها A تكييب ال Delta بC
+
+449
+00:57:56,250 --> 00:58:01,550
+الان
+
+450
+00:58:01,550 --> 00:58:07,350
+CD هي CD CD
+
+451
+00:58:07,350 --> 00:58:14,140
+and force هي هنا عند B هتعمل torsionهيو تعملي
+
+452
+00:58:14,140 --> 00:58:26,420
+torsion عليه اللي هي ال force بمسافة a اللي
+
+453
+00:58:26,420 --> 00:58:35,160
+هو هذا بي سي اللي هو هذا سي دي هذا هو اللي هتعملي
+
+454
+00:58:35,160 --> 00:58:36,900
+torsion
+
+455
+00:58:38,300 --> 00:58:43,240
+و في كمان bending moment اللي هتكون هذه المسافة X
+
+456
+00:58:43,240 --> 00:58:46,260
+يعني
+
+457
+00:58:46,260 --> 00:58:56,320
+هتكون عندي torsion section BC عندي
+
+458
+00:58:56,320 --> 00:59:03,480
+ال bending moment MCD هتكون هذه المسافة X في ال
+
+459
+00:59:03,480 --> 00:59:13,410
+force F Xو في نتورجين CD اللي هيحبها راح تكون F A
+
+460
+00:59:13,410 --> 00:59:31,650
+F A هيكون عندهان DMCD by DF بالساوية X و D TCD by
+
+461
+00:59:31,650 --> 00:59:34,550
+DF بالساوية A
+
+462
+00:59:39,170 --> 00:59:48,070
+مناعته هيكون الـ Delta CD الـ Delta CD هيكون جزءين
+
+463
+00:59:48,070 --> 00:59:56,470
+جزء due to bending تكامل لواحد
+
+464
+00:59:56,470 --> 01:00:00,850
+على EI لل
+
+465
+01:00:00,850 --> 01:00:12,610
+MCD DMCD by DF DXو ال X تغير من صفر ل بيه طوله بيه
+
+466
+01:00:12,610 --> 01:00:19,710
+من صفر ل بيه زائد
+
+467
+01:00:19,710 --> 01:00:25,110
+تكامل لأن في عندي ال torsion المعادلة نرجع لمعادلة
+
+468
+01:00:25,110 --> 01:00:29,470
+ال torsion ال torsion اللي هي هذه المعادلة
+
+469
+01:00:35,820 --> 01:00:45,740
+ال .. ال .. ال .. ال energy المعادلة الأصلية ال
+
+470
+01:00:45,740 --> 01:00:49,460
+torsion هتكون
+
+471
+01:00:49,460 --> 01:00:57,600
+لما اشتغط هذه بيصير واحد على ج ج
+
+472
+01:00:59,710 --> 01:01:21,870
+فى TCD فى DTCD by DF DX وال X تغير من سفر ل V نبدأ
+
+473
+01:01:21,870 --> 01:01:22,470
+نعوضها
+
+474
+01:01:32,110 --> 01:01:40,530
+يعني انا هكون عندي هنا ال delta CD بتساوي تكامل من
+
+475
+01:01:40,530 --> 01:01:57,870
+0 ل B من 0 ل B ل 1 على EI MCD اللي هي F X و DMCD
+
+476
+01:01:57,870 --> 01:02:07,230
+بقى DF اللي هي XDX زاد التكامل من 0 ل V ل 1 على G
+
+477
+01:02:07,230 --> 01:02:22,370
+J TCD اللي هي F في A في A DX يعني
+
+478
+01:02:22,370 --> 01:02:29,610
+هيكون ساوي F على EI تكامل
+
+479
+01:02:32,680 --> 01:02:40,300
+X تربيع DX من 0 ل B زائد
+
+480
+01:02:40,300 --> 01:02:57,680
+1 على GJ تكامل في F طبعا فA تربيع تكامل DX من 0 ل
+
+481
+01:02:57,680 --> 01:02:57,880
+B
+
+482
+01:03:04,500 --> 01:03:15,160
+يعني هكون F B تكييب على تلاتة EI زائد
+
+483
+01:03:15,160 --> 01:03:29,940
+F A تربيع B على G J هذه ال deflectiondeflection في
+
+484
+01:03:29,940 --> 01:03:42,460
+ال .. due to strain energy in section CD ناخد
+
+485
+01:03:42,460 --> 01:03:48,980
+section DG هاخد انا free pedagram ال section DG ال
+
+486
+01:03:48,980 --> 01:03:53,700
+force دي F هيعكسها force هنا F زي دي حكوا انا اللي
+
+487
+01:03:53,700 --> 01:03:57,260
+عليه bending في مستويين فيه bending في هذا الاتجاه
+
+488
+01:03:58,340 --> 01:04:03,100
+و في بننج في هذا الاتجاه يعني هكون عندى في بننج
+
+489
+01:04:03,100 --> 01:04:08,360
+بيحاول بهذا الاتجاه ايه و في بننج بهذا الاتجاه
+
+490
+01:04:08,360 --> 01:04:12,420
+يعني
+
+491
+01:04:12,420 --> 01:04:16,200
+خلينا نسميها MDG 1 و MDG 2
+
+492
+01:04:29,510 --> 01:04:39,550
+م دي جي واحد هتكون
+
+493
+01:04:39,550 --> 01:04:51,630
+اف في ايه هتعمل بنك بهذا الاتجاه اف في ايه دي
+
+494
+01:04:51,630 --> 01:05:04,220
+م دي جي واحد by ديF هتكون السواش A وم ال DG اتنين
+
+495
+01:05:04,220 --> 01:05:14,800
+هتكون بتحاول تلفها زي هيك هتكون F بي F بي يعني
+
+496
+01:05:14,800 --> 01:05:18,800
+هتكون ال DM DG
+
+497
+01:05:18,800 --> 01:05:28,830
+اتنين by DF هتكون السواش بي معناته ال Deltaالـ
+
+498
+01:05:28,830 --> 01:05:36,690
+delta و في عندى axial force axial force معناته ال
+
+499
+01:05:36,690 --> 01:05:42,850
+delta دي جي هتكون
+
+500
+01:05:42,850 --> 01:05:51,890
+due to this bending تكامل لأن نرجع للشكل على طوله
+
+501
+01:05:51,890 --> 01:05:56,130
+C هكون
+
+502
+01:06:00,480 --> 01:06:08,280
+هيكون تكامل عند ال بنج الأولاني واحد على ei تكامل
+
+503
+01:06:08,280 --> 01:06:27,620
+سفر ل C لل M دي جي واحد في ال DMDG 1 by DF DX زائد
+
+504
+01:06:27,620 --> 01:06:34,960
+التكامل من 0 ل C 1 على EI الاخر بين ال component
+
+505
+01:06:34,960 --> 01:06:52,450
+اللي هي M DG 2فى DMDG 2 by DF فى DX زاد فى ان احنا
+
+506
+01:06:52,450 --> 01:06:56,650
+حكينا ال Axial component Axial component اللى هى
+
+507
+01:06:56,650 --> 01:07:09,770
+هى معدلتها لها دى المعدلة تكامل من 0 ل C 1 على AA
+
+508
+01:07:12,410 --> 01:07:19,110
+فى F فى .. فى ال .. فى F فى
+
+509
+01:07:19,110 --> 01:07:29,850
+DF by DF DX اه نبدأ نحل ال integral هيكون يساوي
+
+510
+01:07:29,850 --> 01:07:33,550
+واحد
+
+511
+01:07:33,550 --> 01:07:38,130
+على EI تكامل من صفر لل C
+
+512
+01:07:47,510 --> 01:07:54,710
+الـ MDG 1 حكينا F A و
+
+513
+01:07:54,710 --> 01:08:04,570
+DMG 1 بديها في اللي هي A DX زي التكامل من 0 ل C
+
+514
+01:08:04,570 --> 01:08:15,390
+طبعا 1 على AI بتطلع برا MDG 2 اللي هي FB و
+
+515
+01:08:15,390 --> 01:08:22,760
+DMG 2by df بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+516
+01:08:22,760 --> 01:08:22,820
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+517
+01:08:22,820 --> 01:08:26,180
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+518
+01:08:26,180 --> 01:08:31,140
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+519
+01:08:31,140 --> 01:08:31,160
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+520
+01:08:31,160 --> 01:08:36,840
+بي بي بي بي بي بي بي بي بي بي بي
+
+521
+01:08:36,840 --> 01:08:44,900
+بي
+
+522
+01:08:44,900 --> 01:08:54,620
+بأول تكامل هذا عبارة عن F A تربيع في C F A تربيع
+
+523
+01:08:54,620 --> 01:09:01,260
+في C على EI زاد
+
+524
+01:09:01,260 --> 01:09:14,200
+F B تربيع C على EI زاد
+
+525
+01:09:18,900 --> 01:09:26,100
+Fc على a في a لان
+
+526
+01:09:26,100 --> 01:09:30,240
+خلينا نجمع احنا اكيدنا ال deflection at b عبارة عن
+
+527
+01:09:30,240 --> 01:09:33,640
+deflection for section bc زي ال deflection for
+
+528
+01:09:33,640 --> 01:09:38,980
+section cd زي ال deflection for section dg معناته
+
+529
+01:09:38,980 --> 01:09:41,200
+ال delta ال كلية delta b
+
+530
+01:09:45,670 --> 01:09:50,970
+دلتا بي الكلية هتكون
+
+531
+01:09:50,970 --> 01:09:57,490
+اول واحدة دلتا بي C طلعت معنا F على
+
+532
+01:09:57,490 --> 01:10:06,430
+تلاتة EI في A تكييبة هاي اول واحدة زاد ال
+
+533
+01:10:06,430 --> 01:10:10,210
+deflection due to C دي هي F بي تكييب
+
+534
+01:10:15,040 --> 01:10:25,940
+على تلاتة EI اللي هي هذا ال term زاد F A تربيع B
+
+535
+01:10:25,940 --> 01:10:33,240
+على G في J ال
+
+536
+01:10:33,240 --> 01:10:42,300
+term التالت اللي هو delta DG اللي هو هذا زاد F A
+
+537
+01:10:42,300 --> 01:11:01,200
+تربيع Cعلى EI زائد FB تربيع C على EI زائد FC على A
+
+538
+01:11:01,200 --> 01:11:09,820
+في A هيك
+
+539
+01:11:09,820 --> 01:11:18,380
+حسبنا deflection عن نقطة Bطبعا ممكن تكمل اكتر الان
+
+540
+01:11:18,380 --> 01:11:22,860
+فينا اللي هو ان ال I و ال J و ال A ال A ايش
+
+541
+01:11:22,860 --> 01:11:32,420
+بالساوية باي على اربعة دي التربية و ال I باي على
+
+542
+01:11:32,420 --> 01:11:42,060
+اربعة و ستين دي قصة اربعة و ال J بالساوية باي على
+
+543
+01:11:42,060 --> 01:11:42,940
+اتنين و تلاتين
+
+544
+01:11:45,620 --> 01:11:51,240
+D أص أربعة D
+
+545
+01:11:51,240 --> 01:11:56,960
+أص أربعة و
+
+546
+01:11:56,960 --> 01:12:04,480
+في علاقة بين ال E و ال G من خلال Pies ratio في
+
+547
+01:12:04,480 --> 01:12:06,540
+علاقة بين ال E و ال G من خلال ال Pies ratio ممكن
+
+548
+01:12:06,540 --> 01:12:11,960
+تبسطه و تخلوها بدلالة ال E كلها او بدلالة ال G
+
+549
+01:12:15,400 --> 01:12:19,660
+يعني ممكن تعمل more simplification بس ال .. ال ..
+
+550
+01:12:19,660 --> 01:12:23,900
+ال .. ال main body للمثلة حالناها و بعدين بيصير
+
+551
+01:12:23,900 --> 01:12:32,040
+الشغل شبر و تبسيط و بس يعني .. يعني ممكن يعملوا
+
+552
+01:12:32,040 --> 01:12:38,100
+طلاب أول سنة و تانية سنة ممكن يشتغلوا الشغل زي هيك
+
+553
+01:12:49,860 --> 01:12:54,360
+طيب المرة الجاية بنكمل ال deflection of cared
+
+554
+01:12:54,360 --> 01:13:02,080
+members بعدين هنشوف كيف نحل مسائل غير قابلة للحال
+
+555
+01:13:02,080 --> 01:13:05,420
+باستخدام طرق الاستاتيكا التقليدية
+
+556
+01:13:11,010 --> 01:13:13,950
+اللي هو aesthetically indeterminate problems بعدين
+
+557
+01:13:13,950 --> 01:13:17,830
+ال buckling of compression columns تاكيه نكون
+
+558
+01:13:17,830 --> 01:13:22,090
+خلصنا chapter أربعة طبعا chapter تلاتة و أربعة
+
+559
+01:13:22,090 --> 01:13:27,310
+كانت تحضير و تهيئة لل .. لل judges الأساسي في
+
+560
+01:13:27,310 --> 01:13:31,030
+المادة اللي هي design for aesthetic او aesthetic
+
+561
+01:13:31,030 --> 01:13:34,690
+design و عندنا fatigue design او design for
+
+562
+01:13:34,690 --> 01:13:38,160
+dynamic loadingو فينا design for static loading
+
+563
+01:13:38,160 --> 01:13:42,580
+chapter تلاتة وأربعة تجهيز و تحضير لهدول ال two
+
+564
+01:13:42,580 --> 01:13:47,780
+chapters اللي هو مثله اللي هو قلب المادة
+
diff --git a/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/BTYGbzBT3fw_raw.srt b/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/BTYGbzBT3fw_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..37bda82bd9743e49d7f18937a80d14a7a8561b20
--- /dev/null
+++ b/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/BTYGbzBT3fw_raw.srt
@@ -0,0 +1,2272 @@
+1
+00:00:04,890 --> 00:00:07,550
+بسم الله الرحمن الرحيم السلام عليكم و رحمة الله و
+
+2
+00:00:07,550 --> 00:00:11,870
+بركاته عودة
+
+3
+00:00:11,870 --> 00:00:16,330
+انقلت إلى مادة تصميم الألات واحد احنا بدأنا ب
+
+4
+00:00:16,330 --> 00:00:19,090
+chapter أربعة .. chapter أربعة كان يحكي على ال
+
+5
+00:00:19,090 --> 00:00:21,570
+deflection and stiffness analysis of mechanical
+
+6
+00:00:21,570 --> 00:00:26,930
+membersحنرجع المحاضرة السابقة المحاضرة السابقة we
+
+7
+00:00:26,930 --> 00:00:30,550
+define the strain energy due to forces acting on a
+
+8
+00:00:30,550 --> 00:00:35,030
+mechanical part as U بستو F square على اتنين K ال
+
+9
+00:00:35,030 --> 00:00:40,470
+F اللي هي ال applied force ال K ال stiffness of
+
+10
+00:00:40,470 --> 00:00:44,790
+the mechanical part طبعا ال strain energy كانت
+
+11
+00:00:44,790 --> 00:00:49,630
+تعتمدحالة نوعية ال loading في حالة axial loading
+
+12
+00:00:49,630 --> 00:00:53,990
+سواء كان tension او compression ال formula لل
+
+13
+00:00:53,990 --> 00:00:59,870
+strain energy كانت تكامل لل F² dx على 2 AE ال F هي
+
+14
+00:00:59,870 --> 00:01:03,530
+axial force ال A ال cross section ال area للمنبر
+
+15
+00:01:03,530 --> 00:01:06,690
+ال E ال modulus of elasticity وDx اللي هي
+
+16
+00:01:06,690 --> 00:01:11,090
+displacement بالنسبة
+
+17
+00:01:11,090 --> 00:01:14,030
+لل strain energy ل torsional loading condition
+
+18
+00:01:14,030 --> 00:01:18,860
+كانتis given by this equation U بساوية تكمل T
+
+19
+00:01:18,860 --> 00:01:23,940
+squared على اتنين G J DX ال T اللي هي ال applied
+
+20
+00:01:23,940 --> 00:01:27,960
+torque ال G اللي هي ال modulus of rigidity او ال
+
+21
+00:01:27,960 --> 00:01:34,400
+shear modulus وال J ال polar moment of inertia في
+
+22
+00:01:34,400 --> 00:01:39,750
+حالة direct shear loadingالـ Strain Energy is
+
+23
+00:01:39,750 --> 00:01:45,650
+given by تكامل F² على اتنين A E A A G D X برضه ال
+
+24
+00:01:45,650 --> 00:01:48,990
+F هي ال shear force ال A هي ال cross sectional
+
+25
+00:01:48,990 --> 00:01:51,750
+area الجي الموديلوس of الrigidity او ال shear
+
+26
+00:01:51,750 --> 00:01:59,390
+modulusفي حالة bending loading ال energy is given
+
+27
+00:01:59,390 --> 00:02:05,610
+by the formula U بستوى تكامل M square على 2EIDX ال
+
+28
+00:02:05,610 --> 00:02:08,710
+M هي bending moment at the cross section ال E
+
+29
+00:02:08,710 --> 00:02:14,370
+موديلوس بلاسيسيتي ال I موديلوس cross sectional
+
+30
+00:02:14,370 --> 00:02:20,160
+moment of inertiaفي حالة Transverse Shear Loading
+
+31
+00:02:20,160 --> 00:02:23,020
+وين فيه عندنا bending بيكون عندنا Transverse Shear
+
+32
+00:02:23,020 --> 00:02:25,360
+Loading ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+33
+00:02:25,360 --> 00:02:25,720
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+34
+00:02:25,720 --> 00:02:26,940
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+35
+00:02:26,940 --> 00:02:27,160
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+36
+00:02:27,160 --> 00:02:27,860
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+37
+00:02:27,860 --> 00:02:29,560
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+38
+00:02:29,560 --> 00:02:35,520
+ال ال ال
+
+39
+00:02:35,520 --> 00:02:35,540
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+40
+00:02:35,540 --> 00:02:35,540
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+41
+00:02:35,540 --> 00:02:35,540
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+42
+00:02:35,540 --> 00:02:35,540
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+43
+00:02:35,540 --> 00:02:35,580
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+44
+00:02:35,580 --> 00:02:37,800
+ال ال ال ال ال ال ال ال ال
+
+45
+00:02:45,730 --> 00:02:49,890
+مستطيل مدور or any other cross section تابل أربع
+
+46
+00:02:49,890 --> 00:02:54,770
+واحد بيعطينا قيم ال C for different cross sections
+
+47
+00:02:54,770 --> 00:03:00,130
+في حالة مقطع مستطيل ال C كانت 1.2 في حالة مقطع
+
+48
+00:03:00,130 --> 00:03:09,970
+مدور ال C 1.11 حلين example أربع تمانيةأو جدن
+
+49
+00:03:09,970 --> 00:03:14,790
+دفلكشن عند ال force F باستخدام ال strength energy
+
+50
+00:03:14,790 --> 00:03:20,630
+method هذا آخر الشيء اللي وصلناه اليوم هنكمل اللي
+
+51
+00:03:20,630 --> 00:03:26,150
+هو Castellano theorem Castellano theorem تحكي
+
+52
+00:03:26,150 --> 00:03:30,270
+التالي forces act on anelastic systems subject أو
+
+53
+00:03:30,270 --> 00:03:34,830
+أولش ال Castellano theorem ال application بتاعتها
+
+54
+00:03:34,830 --> 00:03:40,430
+applies only for forcesacting on mechanical
+
+55
+00:03:40,430 --> 00:03:44,510
+elements subjected to small displacements يعني إذا
+
+56
+00:03:44,510 --> 00:03:48,030
+كانت ال displacement كبيرة Castellano theorem is
+
+57
+00:03:48,030 --> 00:03:51,990
+not valid يعني we apply Castellano theorem in case
+
+58
+00:03:51,990 --> 00:03:56,570
+of forces acting on mechanical elements with small
+
+59
+00:03:56,570 --> 00:04:01,770
+displacement الآن
+
+60
+00:04:01,770 --> 00:04:05,350
+according to Castellano displacement
+
+61
+00:04:07,200 --> 00:04:11,620
+corresponding to any force along its direction لو
+
+62
+00:04:11,620 --> 00:04:19,180
+عندي mechanical element طبعا
+
+63
+00:04:19,180 --> 00:04:28,200
+نتيجة ال loading حاسيبي عندي إيش؟ deflection هذا
+
+64
+00:04:28,200 --> 00:04:33,360
+ال force F هذا كانت liver beam according to
+
+65
+00:04:33,360 --> 00:04:37,930
+Castellano ال displacement Deltais given by ال
+
+66
+00:04:37,930 --> 00:04:41,930
+partial differential لل total strain energy
+
+67
+00:04:41,930 --> 00:04:49,090
+بالنسبة لل force F يعني displacement Delta بيساوي
+
+68
+00:04:49,090 --> 00:04:54,670
+ال partial derivative لل total strain energy with
+
+69
+00:04:54,670 --> 00:04:59,730
+respect to the force F هذا في حالة force في حالة
+
+70
+00:04:59,730 --> 00:05:05,170
+rotationروتيشنال ديسبلسمنت الـθيتا بساوية دي يو
+
+71
+00:05:05,170 --> 00:05:23,110
+باي دي ام خليني
+
+72
+00:05:23,110 --> 00:05:27,250
+احل مثال ان شوف كيف ممكن استخدم الcastellano
+
+73
+00:05:27,250 --> 00:05:31,590
+theorem نفس ال example السابق
+
+74
+00:05:34,380 --> 00:05:38,360
+the cantilever shown في عندى cantilever مثبت من
+
+75
+00:05:38,360 --> 00:05:44,740
+الطرف هذا is a carbon steel bar عبارة عن بار مصنوع
+
+76
+00:05:44,740 --> 00:05:53,120
+من الحديد الكربوني ten inch long طوله
+
+77
+00:05:53,120 --> 00:05:57,820
+ال مستوى
+
+78
+00:05:57,820 --> 00:05:59,680
+ten inch long
+
+79
+00:06:02,460 --> 00:06:08,620
+والقطر بتاع المقطع مدور بسوا
+
+80
+00:06:08,620 --> 00:06:27,100
+واحد انش ومدور بفرصة F بسوا
+
+81
+00:06:27,100 --> 00:06:27,940
+ميت باوند
+
+82
+00:06:34,160 --> 00:06:39,480
+Find maximum deflection using
+
+83
+00:06:39,480 --> 00:06:43,440
+Castellano theorem including that due to shear
+
+84
+00:06:43,440 --> 00:06:57,700
+اوجد ال maximum deflection بده y max ال
+
+85
+00:06:57,700 --> 00:07:02,100
+y هتكون الساوية du
+
+86
+00:07:04,120 --> 00:07:12,920
+أو partial by
+
+87
+00:07:12,920 --> 00:07:18,800
+DF ال
+
+88
+00:07:18,800 --> 00:07:26,540
+U هتكون مكونة من two components U هتكون strain
+
+89
+00:07:26,540 --> 00:07:34,860
+energy due to bending زي Udue to transverse shear
+
+90
+00:07:34,860 --> 00:07:42,220
+U S لو
+
+91
+00:07:42,220 --> 00:07:50,740
+أخدت section هنا على بعد X طلعت
+
+92
+00:07:50,740 --> 00:07:59,040
+أخدت free body diagram هاي ال force F هذه المسافة
+
+93
+00:07:59,040 --> 00:08:00,980
+X
+
+94
+00:08:02,860 --> 00:08:08,660
+فى عندى force F فى
+
+95
+00:08:08,660 --> 00:08:16,320
+عندى moment M أو
+
+96
+00:08:16,320 --> 00:08:17,860
+V
+
+97
+00:08:22,820 --> 00:08:28,020
+طبعا هكون عند ال .. ال .. ال .. ال .. ال V قيمتها
+
+98
+00:08:28,020 --> 00:08:44,800
+هتكون تساوي F و ال M هتكون بتساوي F X الان
+
+99
+00:08:44,800 --> 00:08:49,040
+ال U due to bending نرجع للمعادلات .. للمعادلات
+
+100
+00:08:49,040 --> 00:08:51,600
+السابقة ال U due to bending U
+
+101
+00:08:55,140 --> 00:09:08,520
+بتساوي تكامل M squared على 2EI في DX هتساوي
+
+102
+00:09:08,520 --> 00:09:20,000
+تكامل طبعا هي متكامل من 0 لأقل ال M عنده اللي هي F
+
+103
+00:09:20,000 --> 00:09:31,890
+X الكل تربيععلى اتنين EI DX من سفر لأقل بتساوي
+
+104
+00:09:31,890 --> 00:09:40,910
+طبعا عندي ال F is constant فحسي عندي F square على
+
+105
+00:09:40,910 --> 00:09:54,050
+اتنين EI تكامل X square DX من سفر لأقلهتساوي تكوين
+
+106
+00:09:54,050 --> 00:10:05,770
+X² X تكييب على تلاتة يعني هذه هتصير F² L تكييب على
+
+107
+00:10:05,770 --> 00:10:17,690
+6EI ال
+
+108
+00:10:17,690 --> 00:10:19,530
+U due to shear
+
+109
+00:10:25,570 --> 00:10:32,790
+transfer share هي تكامل C
+
+110
+00:10:32,790 --> 00:10:47,690
+V square على 2 A G من 0 لL هي الساوى تكامل ال C
+
+111
+00:10:47,690 --> 00:10:53,870
+constant ال C في الحالة هادة لمقطع مضور من الجدول
+
+112
+00:10:55,880 --> 00:11:05,000
+للمقطع المدور C بساوية واحد point واحد واحد هتكون
+
+113
+00:11:05,000 --> 00:11:18,240
+C F square على اتنين A G DX طبعا
+
+114
+00:11:18,240 --> 00:11:23,940
+انا عند ال C و ال F و ال A و ال G ثوابت من 0 ل L
+
+115
+00:11:25,710 --> 00:11:34,390
+معناته التكوينة ستكون C F²
+
+116
+00:11:34,390 --> 00:11:38,590
+L 2A
+
+117
+00:11:38,590 --> 00:11:46,910
+G يعني
+
+118
+00:11:46,910 --> 00:11:54,710
+انا اقول ان الـ Deflection Y بالساوية DUby DF
+
+119
+00:11:54,710 --> 00:12:06,190
+بتساوي DU due to pending by DF زي DU due to share
+
+120
+00:12:06,190 --> 00:12:18,490
+by DF احنا هنا ممكن نعرف اللي
+
+121
+00:12:18,490 --> 00:12:19,770
+هو DU pending
+
+122
+00:12:23,530 --> 00:12:32,970
+by DF هتكون الساوية اتنين F التكييب على ستة AI
+
+123
+00:12:32,970 --> 00:12:45,310
+يعني هتساوية F التكييب على تلاتة AI وDUS
+
+124
+00:12:45,310 --> 00:12:51,370
+by DF بساوية اتنين C
+
+125
+00:12:53,310 --> 00:13:07,250
+F L على اتنين A G يعني أنا هستقل C F L على A G
+
+126
+00:13:07,250 --> 00:13:13,530
+يعني
+
+127
+00:13:13,530 --> 00:13:21,250
+انا ممكن احكي Y هيبقى على مؤكونين Y due to bending
+
+128
+00:13:22,520 --> 00:13:32,480
+z y due to share ال y due to bending ال
+
+129
+00:13:32,480 --> 00:13:45,580
+هي du bending by df بتساوي لأفقال تكيب على
+
+130
+00:13:45,580 --> 00:13:49,120
+تلاتة ei
+
+131
+00:13:59,950 --> 00:14:05,430
+خلّيني أحسب بعض الشغلات هنا أنا
+
+132
+00:14:05,430 --> 00:14:10,470
+بدي أحسب المقطع المدور ال A بالساوية باي على أربعة
+
+133
+00:14:10,470 --> 00:14:17,890
+دي تربيع يعني باي على أربعة في واحد تربيع بالساوية
+
+134
+00:14:17,890 --> 00:14:26,010
+باي على أربعة هذه ال area و ال I بالساوية باي على
+
+135
+00:14:26,010 --> 00:14:31,500
+أربعة و ستين دي بس أربعةيعني هيكون باي على اربعة و
+
+136
+00:14:31,500 --> 00:14:44,840
+ستين في واحد تربيع يعني باي على اربعة و ستين ال
+
+137
+00:14:44,840 --> 00:14:51,160
+E من الجداول ال E لل carbon steel بيساوي تلاتين
+
+138
+00:14:51,160 --> 00:15:01,620
+ميجا باوند per square inch وال Gبساوي احداش و نص
+
+139
+00:15:01,620 --> 00:15:10,620
+جيجاباوند per square inch او
+
+140
+00:15:10,620 --> 00:15:20,940
+ميجاباوند per square
+
+141
+00:15:20,940 --> 00:15:25,120
+inch يعني
+
+142
+00:15:25,120 --> 00:15:27,240
+ال why due to pending هتكون
+
+143
+00:15:29,740 --> 00:15:39,460
+اللف عندي أكم؟ معطني أمية وال L عشرة في عشرة تكيب
+
+144
+00:15:39,460 --> 00:15:57,040
+على تلاتة ال E في تلاتين في عشرة أقل ستة في ال I
+
+145
+00:15:57,040 --> 00:16:05,330
+اللي هي بايعلى اربعة و ستين و بنحسب ال Y due to
+
+146
+00:16:05,330 --> 00:16:09,970
+pending ال
+
+147
+00:16:09,970 --> 00:16:16,590
+Y due to share اللي
+
+148
+00:16:16,590 --> 00:16:24,190
+هي هتكون DUS by DF نعملها بالساعة والسي
+
+149
+00:16:26,850 --> 00:16:36,870
+F L على A في G ال C واحد point واحد واحد ال F مية
+
+150
+00:16:36,870 --> 00:16:46,990
+وال L عشرة وال A باي على أربع باي على أربع وال G
+
+151
+00:16:46,990 --> 00:16:53,590
+خلينا نتاكد ال G للحديد أحداشر نص ميجا
+
+152
+00:16:59,160 --> 00:17:00,360
+هنفتح الجداول
+
+153
+00:17:33,200 --> 00:17:40,760
+اللي هو A5 عندنا هيكون ال
+
+154
+00:17:40,760 --> 00:17:48,500
+carbon steel ال ال G 11.5 ميجا باوند per square
+
+155
+00:17:48,500 --> 00:17:55,440
+inch وال A30 صحيح طيب
+
+156
+00:17:55,440 --> 00:17:57,640
+ال G 11.5
+
+157
+00:18:01,300 --> 00:18:11,160
+في عشرة في الستة و بنحسبها لو
+
+158
+00:18:11,160 --> 00:18:21,480
+حسبنا ال why due to pending هيكون عنده
+
+159
+00:18:21,480 --> 00:18:25,160
+مية
+
+160
+00:18:25,160 --> 00:18:36,440
+في الف في اربعة و ستينعلى تسعين
+
+161
+00:18:36,440 --> 00:18:51,200
+على أشهر و ستة بيطلع
+
+162
+00:18:51,200 --> 00:18:57,780
+عندى point او اتنين اتنين ستة point او اتنين اتنين
+
+163
+00:18:57,780 --> 00:19:02,850
+ستةالـ why do you cheer لحالها
+
+164
+00:19:34,040 --> 00:19:42,600
+بيطلع point o o واحد من عشر تلاف point o o واحد
+
+165
+00:19:42,600 --> 00:19:49,580
+انش معناه ال total deflection y هيكون مجموعهم
+
+166
+00:19:49,580 --> 00:19:59,700
+point o اتنين اتنين ستة زي point o o o واحد يعني
+
+167
+00:19:59,700 --> 00:20:09,400
+هيكون point oاتنين اتنين سبعة انش
+
+168
+00:20:42,930 --> 00:20:48,330
+طيب هذا المطلوب التاني what error is introduced if
+
+169
+00:20:48,330 --> 00:20:51,030
+shear is neglected إذا أهملت الشير يعني اعتبرت
+
+170
+00:20:51,030 --> 00:21:02,290
+الشير مهمل يعني لو حكيت if shear is
+
+171
+00:21:02,290 --> 00:21:06,650
+neglected هكون
+
+172
+00:21:06,650 --> 00:21:14,510
+ال y هي ال y بتاعة ال bendingبس تقريبا بتساوي اللي
+
+173
+00:21:14,510 --> 00:21:24,110
+هي point o اتنين اتنين ست انش لو لان نحصل
+
+174
+00:21:24,110 --> 00:21:32,110
+percentage error due to ignorance of shear هيكون
+
+175
+00:21:32,110 --> 00:21:39,130
+ساوي اللي هو point o اتنين اتنين سبعة minus point
+
+176
+00:21:39,130 --> 00:21:54,080
+o2 2 6 على point o 227 في 100 يعني
+
+177
+00:21:54,080 --> 00:21:54,580
+هيكون
+
+178
+00:22:30,440 --> 00:22:37,340
+بطلع نسبة الخطأ point 4 4 بالمية point 4 4 percent
+
+179
+00:22:37,340 --> 00:22:43,160
+معناته ال .. اذا في معظم الأحيان اذا كان موجود
+
+180
+00:22:43,160 --> 00:22:47,540
+عندي bending و transverse shear ال deflection due
+
+181
+00:22:47,540 --> 00:22:53,700
+to transverse shear صغير جدا بالمقارنة مع ال .. ال
+
+182
+00:22:53,700 --> 00:22:58,040
+deflection due to bending و الدليل لما حسبنا هنا
+
+183
+00:22:58,040 --> 00:23:03,810
+طلعت الخطأفي ال .. في الإجابة bond for 4% إذا
+
+184
+00:23:03,810 --> 00:23:09,110
+أهملت ال .. إيش؟ ال sheer effect وبتاع بشكل عام
+
+185
+00:23:09,110 --> 00:23:12,990
+احنا ممكن نهمل ال sheer effect لإنه is not
+
+186
+00:23:12,990 --> 00:23:20,170
+significant ليس دو قيمة نكمل
+
+187
+00:23:20,170 --> 00:23:20,810
+طيب
+
+188
+00:23:45,440 --> 00:23:50,380
+أحنا حكيها من الشروط بتاعة Castellano عشان أحس ب
+
+189
+00:23:50,380 --> 00:23:55,360
+deflection at any location لازم تكون اتأثر force
+
+190
+00:23:55,360 --> 00:23:57,840
+عند ال location تحت الدراسة يعني لو أنا هي عندي
+
+191
+00:23:57,840 --> 00:24:05,890
+cantilever وفي عنديforce F بدي أحسب النقطة هذه في
+
+192
+00:24:05,890 --> 00:24:11,430
+force F بتأثر طيب إذا بدي أحسب النقطة هذه مافيش
+
+193
+00:24:11,430 --> 00:24:20,730
+force F اللي بقى أسوي إنه بحط قوة خيالية بسميها
+
+194
+00:24:20,730 --> 00:24:29,920
+اكيو و بحسبالـ total strain energy كما لو كانت Q
+
+195
+00:24:29,920 --> 00:24:39,200
+موجودة طبعا F موجودة بعدين بحسب Delta سواء Du by
+
+196
+00:24:39,200 --> 00:24:45,760
+DQ بعدين بحط Q بالساوية سفر لأنه مش موجود أصلا
+
+197
+00:24:45,760 --> 00:24:51,430
+يعنيفمعناته من مستلزمات Castellano's theorem إذا
+
+198
+00:24:51,430 --> 00:24:55,610
+أنا بدي أحسب ال deflection at any location لازم
+
+199
+00:24:55,610 --> 00:24:58,250
+يكون فيه عندى قوة أثر باتجاه ال deflection المطلوب
+
+200
+00:24:58,250 --> 00:25:02,410
+حسابهوبالتالي إذا مش موجود ال force هذا بدي أحط
+
+201
+00:25:02,410 --> 00:25:06,790
+قوة تخيلية Q بحسب ال total external energy given
+
+202
+00:25:06,790 --> 00:25:12,250
+يعني بوجود Q ووجود F بعدين بحسب ال Delta سوى Du by
+
+203
+00:25:12,250 --> 00:25:16,890
+DQ بعد ما أحكي ال Delta سوى Du by DQ بحط Q بساوية
+
+204
+00:25:16,890 --> 00:25:22,190
+0 يعني طريقة تحيل .. تحيلنا على ال theorem و بعدين
+
+205
+00:25:22,190 --> 00:25:25,310
+في الآخر صفرنا ال Q اللي هي ال .. ال Q الخيالية
+
+206
+00:25:35,690 --> 00:25:42,370
+أحنا لما كنا نحسب ال total strain energy لما كنا
+
+207
+00:25:42,370 --> 00:25:45,930
+نحسب ال total strain energy مثلا لو أخدنا على سبيل
+
+208
+00:25:45,930 --> 00:25:51,410
+المثال ال building كنا
+
+209
+00:25:51,410 --> 00:25:55,830
+نحكي ال U بالساعة
+
+210
+00:25:55,830 --> 00:26:03,810
+التكامل M² على 2EI dx
+
+211
+00:26:05,440 --> 00:26:11,100
+لحظوا انا لما احسب ال M و تكون function of X و
+
+212
+00:26:11,100 --> 00:26:15,640
+اربعها بصير عندي ال integral يعني معقد و في الأخر
+
+213
+00:26:15,640 --> 00:26:20,040
+انا في الأخر هعمل partial derivative لكن لو روح
+
+214
+00:26:20,040 --> 00:26:28,680
+ادخلت ال partial حكيت ال delta بيستوى Du by Df
+
+215
+00:26:28,680 --> 00:26:40,650
+يعني هيكون D by Dfلتكامل M2 على 2EI DX ودخلت الـ
+
+216
+00:26:40,650 --> 00:26:49,970
+differential لجوة حسينا دي تكامل 1 على 2EI D by DF
+
+217
+00:26:49,970 --> 00:27:01,940
+ل M2 DX حسينا دي 1 على 2EIDifferential M with
+
+218
+00:27:01,940 --> 00:27:13,660
+respect to F هتكون M هتكون اتنين M في DM by DF DX
+
+219
+00:27:13,660 --> 00:27:27,300
+اتنين مع اتنين بتصفه سوى واحد على EI في M DM by DF
+
+220
+00:27:27,300 --> 00:27:35,630
+DXDX يعني انا ممكن ادخل ال differential جوا
+
+221
+00:27:35,630 --> 00:27:38,370
+ال integral هذا بسهل كتير الشغل بسهل ال
+
+222
+00:27:38,370 --> 00:27:43,190
+integration بشكل كبير جدا لان already انا ماخدت ال
+
+223
+00:27:43,190 --> 00:27:47,730
+differential of M with respect to the force اللي
+
+224
+00:27:47,730 --> 00:27:54,110
+عندها ال deflection بنفس الملهجية اذا كان عندى
+
+225
+00:27:54,110 --> 00:27:58,840
+only tensionبدخل الـ differential جوا بيصير ان الـ
+
+226
+00:27:58,840 --> 00:28:03,060
+delta I ال location I بيصيح واحدة على AE في FDF by
+
+227
+00:28:03,060 --> 00:28:09,840
+DFI DX و theta I due to bending واحدة على GJ في
+
+228
+00:28:09,840 --> 00:28:14,360
+TDT
+
+229
+00:28:14,360 --> 00:28:21,480
+by DMI و delta I due to bending هتكون واحدة دي I
+
+230
+00:28:21,480 --> 00:28:23,700
+في MDM by DFI في DX
+
+231
+00:28:28,190 --> 00:28:46,910
+تشوف مثال تاني تشوف
+
+232
+00:28:46,910 --> 00:28:51,650
+مثال تاني using
+
+233
+00:28:51,650 --> 00:28:56,010
+Castellanos method باستخدام طريقة Castellanos
+
+234
+00:28:57,700 --> 00:29:03,340
+determine deflections of points A and B نقطة A
+
+235
+00:29:03,340 --> 00:29:11,360
+ونقطة B نقطة A ونقطة
+
+236
+00:29:11,360 --> 00:29:21,480
+B due to the force F نقطة F نقطة F نقطة F نقطة F
+
+237
+00:29:21,480 --> 00:29:24,940
+نقطة F نقطة F نقطة F نقطة
+
+238
+00:29:27,670 --> 00:29:33,110
+الموقعات الثانية للمقاطع A B وهذا مقاطع A B وهذا
+
+239
+00:29:33,110 --> 00:29:39,730
+مقاطع B C R
+
+240
+00:29:39,730 --> 00:29:46,710
+I واحد واتنين
+
+241
+00:29:46,710 --> 00:29:50,630
+I واحد respectively
+
+242
+00:29:52,220 --> 00:29:56,240
+بيده deflection عند a و deflection عند b لان خيانه
+
+243
+00:29:56,240 --> 00:30:03,040
+find deflection at a find deflection
+
+244
+00:30:03,040 --> 00:30:07,180
+at
+
+245
+00:30:07,180 --> 00:30:12,160
+a اول
+
+246
+00:30:12,160 --> 00:30:18,460
+شي اللحظه ان المقطع مش منتظم المقطع عند في الجزء
+
+247
+00:30:18,460 --> 00:30:23,320
+الاول يعني من a لbمختلف عن المقطع في الجزء من B لC
+
+248
+00:30:23,320 --> 00:30:30,160
+I واحد هنا عند ال I للمقطع BC ضعف ال I للمقطع AB
+
+249
+00:30:30,160 --> 00:30:34,340
+احنا
+
+250
+00:30:34,340 --> 00:30:39,980
+في المثال السابق اثبتنا ان قيمة ال deflection due
+
+251
+00:30:39,980 --> 00:30:46,160
+to transverse shear is very small compared to that
+
+252
+00:30:46,160 --> 00:30:51,430
+due to bendingour assumption we neglect deflection
+
+253
+00:30:51,430 --> 00:30:59,010
+due to transverse shear معناته neglect اهمل
+
+254
+00:30:59,010 --> 00:31:06,470
+deflection due
+
+255
+00:31:06,470 --> 00:31:13,670
+to transverse shear
+
+256
+00:31:13,670 --> 00:31:16,310
+هاي أول assumption
+
+257
+00:31:19,160 --> 00:31:26,460
+عندي هاي ال X Axis و
+
+258
+00:31:26,460 --> 00:31:32,280
+هاي ال Y Axis الان
+
+259
+00:31:32,280 --> 00:31:39,960
+at any given section على بعد X هاخد free body
+
+260
+00:31:39,960 --> 00:31:46,300
+diagram هاي
+
+261
+00:31:46,300 --> 00:31:47,200
+ال force F
+
+262
+00:31:50,470 --> 00:32:01,710
+عدي المسافة X هنا هكون في عنده F هكون في عنده
+
+263
+00:32:01,710 --> 00:32:06,270
+moment M لاحظوا
+
+264
+00:32:06,270 --> 00:32:09,190
+لما أنا مش هاهتم في إشارتها negative ولا positive
+
+265
+00:32:09,190 --> 00:32:13,090
+لأنه في الآخر هضرب two terms negative مع negative
+
+266
+00:32:13,090 --> 00:32:18,610
+إيش هيعطيلي positive وبالتالي مش هيأثر كتير أو مش
+
+267
+00:32:18,610 --> 00:32:29,510
+هيأثرالإشارة على الحل عند ال moment هتكون بستوي
+
+268
+00:32:29,510 --> 00:32:34,790
+F X I
+
+269
+00:32:34,790 --> 00:32:42,370
+have only bending معناته ال delta عند A هتكون
+
+270
+00:32:42,370 --> 00:32:42,870
+بستوي
+
+271
+00:32:49,010 --> 00:32:52,370
+طالبا انا عندي ال two sections مختلفين عن بعض
+
+272
+00:32:52,370 --> 00:32:57,710
+بيبقى جزء ال مثل الجزءين جزء a,b زاد الجزء b,c
+
+273
+00:32:57,710 --> 00:33:11,050
+وانا عندي I have only bending هتكون delta a هتكون
+
+274
+00:33:11,050 --> 00:33:16,410
+تساوي تكامل
+
+275
+00:33:18,840 --> 00:33:24,220
+واحد على EI ل
+
+276
+00:33:24,220 --> 00:33:37,080
+M DM by DF DX طبعا
+
+277
+00:33:37,080 --> 00:33:42,900
+عندي two terms او عندي two sections واحد على EI
+
+278
+00:33:42,900 --> 00:33:46,480
+واحد من سفر ل L على اتنين
+
+279
+00:33:49,740 --> 00:33:59,780
+زائد واحد على E احنا حكينا I2 اتنين
+
+280
+00:33:59,780 --> 00:34:03,740
+I واحد زائد
+
+281
+00:34:03,740 --> 00:34:09,540
+واحد على E I اتنين اللي هي عبارة عن اتنين I واحد
+
+282
+00:34:09,540 --> 00:34:12,640
+في
+
+283
+00:34:12,640 --> 00:34:13,640
+M
+
+284
+00:34:19,240 --> 00:34:30,700
+DM by DF DX ال X تغير من L على 2 ل L انا رودي عند
+
+285
+00:34:30,700 --> 00:34:44,020
+ال F بالساوية FX ال M معناته
+
+286
+00:34:44,020 --> 00:34:54,330
+DMو بعدين F هتكون تساوياش X يعني
+
+287
+00:34:54,330 --> 00:35:05,190
+Delta A هتكون تساوي تكامل من 0 ل L على 2 1 على E I
+
+288
+00:35:05,190 --> 00:35:22,610
+1 ال M عندى عبارة عن F Xو DMYDF F X DX زاد التكامل
+
+289
+00:35:22,610 --> 00:35:40,770
+من L على 2 ل L 1 على 2 E I 1 M F X F X DX حيساوى
+
+290
+00:35:40,770 --> 00:35:51,950
+حيطلع عني طبعا برا اللي هوF على E I واحد تكامل
+
+291
+00:35:51,950 --> 00:36:01,770
+من صفر ل L على اتنين ل X تربيع DX زائد واحد على
+
+292
+00:36:01,770 --> 00:36:03,650
+اتنين E I واحد
+
+293
+00:36:06,900 --> 00:36:16,780
+فى F طبعا تكامل من L على 2 لL ل X تربيع DX حيث
+
+294
+00:36:16,780 --> 00:36:22,180
+ساوى طبعا أول تكامل هيكون قيمته هصيرها DX تكييب
+
+295
+00:36:22,180 --> 00:36:32,560
+على 3 من 0 لL على 2 يعني هيكون عندي F L
+
+296
+00:36:32,560 --> 00:36:41,110
+تكييبعلى اربع و عشرين اي
+
+297
+00:36:41,110 --> 00:36:45,990
+اي واحد زائد
+
+298
+00:36:45,990 --> 00:36:49,130
+اف
+
+299
+00:36:49,130 --> 00:36:59,390
+على اتنين اي اي واحد طبعا هنا ستة هيكون في
+
+300
+00:36:59,390 --> 00:37:03,210
+هيكون لتكييب
+
+301
+00:37:06,810 --> 00:37:16,390
+مينوس التى كيب على تمانية يعني
+
+302
+00:37:16,390 --> 00:37:25,670
+Delta A هتكون تستوى F التى كيب على اربع وعشرين E I
+
+303
+00:37:25,670 --> 00:37:32,150
+واحد زائد طبعا هنا التى كيب ناقص التى كيب على
+
+304
+00:37:32,150 --> 00:37:32,650
+تمانية
+
+305
+00:37:39,520 --> 00:37:45,440
+هتكون سبعة على تمانية تمانية بستة تمانية أربعين
+
+306
+00:37:45,440 --> 00:37:57,600
+على تمانية أربعين في
+
+307
+00:37:57,600 --> 00:37:58,020
+سبعة
+
+308
+00:38:06,440 --> 00:38:14,760
+يعنى deflection هكون ساوى هجمعهم عشرة او
+
+309
+00:38:14,760 --> 00:38:19,820
+تسعة هتكون
+
+310
+00:38:19,820 --> 00:38:28,620
+سبعة زائد اتنين سبعة زائد اتنين تسعة تسعة if ال
+
+311
+00:38:28,620 --> 00:38:38,700
+تكييب على التمانية و اربعينEI واحد يعني انا هيكون
+
+312
+00:38:38,700 --> 00:38:49,540
+عند ايه تلاتة F التكييب على ستاشر EI واحد هذه ال
+
+313
+00:38:49,540 --> 00:38:54,300
+deflection عند ايه طبعا
+
+314
+00:38:54,300 --> 00:39:01,680
+بتوقع منكم تتراجعوا الاحسابات هذه ورايااتأكدوا من
+
+315
+00:39:01,680 --> 00:39:10,080
+دقتها إذا في أي خطأ صححه طيب
+
+316
+00:39:10,080 --> 00:39:13,220
+هذا
+
+317
+00:39:13,220 --> 00:39:15,560
+المطلوب الأول المطلوب التاني بدحس ال deflection
+
+318
+00:39:15,560 --> 00:39:16,380
+عند B
+
+319
+00:39:30,580 --> 00:39:34,860
+الان عند B مافيش
+
+320
+00:39:34,860 --> 00:39:40,440
+force عشان أحسن deflection عند B لازم أحط force
+
+321
+00:39:40,440 --> 00:39:48,460
+تخيّلية بدي أحط force تخيّلية واسميها
+
+322
+00:39:48,460 --> 00:39:53,420
+H EQ معناته
+
+323
+00:39:53,420 --> 00:39:58,640
+ال deflection عند B دلتا B هيكون بساوة
+
+324
+00:40:01,310 --> 00:40:05,750
+اللي هو دلتا
+
+325
+00:40:05,750 --> 00:40:16,630
+عند بي سوى دي يو باي دي كيو We
+
+326
+00:40:16,630 --> 00:40:21,250
+have only bending و
+
+327
+00:40:21,250 --> 00:40:26,190
+أهملنا للtransverse shear رقم واحد رقم اتنين
+
+328
+00:40:28,800 --> 00:40:35,500
+لازم انقسم ال beam ل two parts لسببين أول السبب
+
+329
+00:40:35,500 --> 00:40:39,380
+الأول انه انا عندي ال section في ال a,b مساحة
+
+330
+00:40:39,380 --> 00:40:42,760
+المقطع مختلفة عن مساحة المقطع في ال section ب,c
+
+331
+00:40:42,760 --> 00:40:49,940
+سبب تاني صار في عندي كمان قوة مركزة تخيلوا ليها Q
+
+332
+00:40:49,940 --> 00:40:51,120
+عند نقطة B
+
+333
+00:41:01,080 --> 00:41:06,700
+معناته هاخد ال free body diagram في الفترة من a ل
+
+334
+00:41:06,700 --> 00:41:16,860
+b يعني هاخد أول شي section هي section على بعد X لو
+
+335
+00:41:16,860 --> 00:41:25,220
+أخد section على بعد X هي عندي false F وهذه المسافة
+
+336
+00:41:25,220 --> 00:41:29,540
+إيش X هيكون
+
+337
+00:41:29,540 --> 00:41:53,190
+عندي هنا Fوعندي M خصمها MAB MAB بتساوي FX
+
+338
+00:41:53,190 --> 00:41:58,090
+هاي الحالة لقول الحالة التانية هاخد section هنا
+
+339
+00:42:01,650 --> 00:42:09,630
+هذه هي ال X عندي اللي
+
+340
+00:42:09,630 --> 00:42:17,910
+هي ال section التاني هذه
+
+341
+00:42:17,910 --> 00:42:28,130
+A هذه B وعندي هنا F وعندي هنا Q وعندي هذه المسافة
+
+342
+00:42:28,130 --> 00:42:28,970
+أيهاش كلها X
+
+343
+00:42:33,140 --> 00:42:40,420
+هذه المسافة L على 2 هين
+
+344
+00:42:40,420 --> 00:42:46,820
+هيكون طبعا force V بتعكسهم وفي
+
+345
+00:42:46,820 --> 00:43:01,400
+bending moment M V C و M V C هتساوي F
+
+346
+00:43:01,400 --> 00:43:01,880
+X
+
+347
+00:43:09,900 --> 00:43:17,460
+زائد Q في
+
+348
+00:43:17,460 --> 00:43:26,900
+X ناقص L على اتنين هنا
+
+349
+00:43:26,900 --> 00:43:32,060
+لازم نحسب DMAB
+
+350
+00:43:32,060 --> 00:43:34,420
+BY DQ
+
+351
+00:43:37,610 --> 00:43:45,950
+0 لأن هذه F وهذه X هنا سأحسب DMBC
+
+352
+00:43:45,950 --> 00:43:56,570
+BY DQ هتكون سفر زائد X minus L على اتنين
+
+353
+00:44:10,710 --> 00:44:19,470
+I have only bending معناته delta B هتكون تساوي انا
+
+354
+00:44:19,470 --> 00:44:30,110
+هقسم لجزئين من A ل B و من B ل C تكامل من 0 ل L على
+
+355
+00:44:30,110 --> 00:44:37,630
+2 ل 1 على E ال section AB ال I تعته I واحد
+
+356
+00:44:41,260 --> 00:44:46,320
+في MAB DMAB
+
+357
+00:44:46,320 --> 00:45:01,000
+by DQ DX زائد التكامل من L على 2 لL في 1 على E ال
+
+358
+00:45:01,000 --> 00:45:05,000
+I بتاع ال section 2 عبارة عن 2EI 1
+
+359
+00:45:10,240 --> 00:45:23,420
+م بي سي دي ام بي سي بي دي كيو دي اكس
+
+360
+00:45:23,420 --> 00:45:27,980
+احنا already we find دي ام ا بي بي دي كيو بالساوة
+
+361
+00:45:27,980 --> 00:45:35,140
+صفر معناه الترم الأول هذا الترم كله
+
+362
+00:45:35,140 --> 00:45:45,930
+هذا بالساوة صفرمعنى انت هتصفح delta P بالساعة
+
+363
+00:45:45,930 --> 00:45:57,310
+واحدة تكامل من L على 2 ل L هطلع واحد على اتنين EI
+
+364
+00:45:57,310 --> 00:46:03,110
+واحد متعود عن MBC MBC عبارة عن FX
+
+365
+00:46:10,030 --> 00:46:23,210
+زاد Q في X minus L على 2 هذا ال MBC في DMBC by DQ
+
+366
+00:46:23,210 --> 00:46:31,810
+اللي هي X minus L على 2 في DX
+
+367
+00:46:36,220 --> 00:46:42,000
+الان set up كيو باسمها و سفر خل كيو هذه و حط كيو
+
+368
+00:46:42,000 --> 00:46:46,620
+باسمها و سفر احنا
+
+369
+00:46:46,620 --> 00:46:57,280
+اتحيلنا عليها بس هتصف هذه تكامل واحد
+
+370
+00:46:57,280 --> 00:47:10,490
+على اتنين E I واحد تكامل من ال على اتنينلL ل
+
+371
+00:47:10,490 --> 00:47:15,750
+FX في
+
+372
+00:47:15,750 --> 00:47:29,310
+X minus L على 2 DX يعني هتسير هطلع ال F برا ف F
+
+373
+00:47:29,310 --> 00:47:42,710
+على 2EI 1تكامل من L على 2 ل L هدخل X لجوه X تربيع
+
+374
+00:47:42,710 --> 00:48:01,070
+minus XL على 2 DX يعني هتكون F على 2 E I 1في تكامل
+
+375
+00:48:01,070 --> 00:48:11,230
+X تربيع عبارة عن إيش في X تكييب على تلاتة minus X
+
+376
+00:48:11,230 --> 00:48:20,130
+تربيع L على أربعة والتكامل حدوده من L على اتنين ل
+
+377
+00:48:20,130 --> 00:48:27,650
+L يعني هيكون يساوي F
+
+378
+00:48:29,210 --> 00:48:37,970
+على اتنين E I واحد في تلت
+
+379
+00:48:37,970 --> 00:48:41,830
+ال
+
+380
+00:48:41,830 --> 00:48:45,730
+تكييب minus
+
+381
+00:48:45,730 --> 00:48:53,130
+ال تكييب على تمانية minus
+
+382
+00:48:53,130 --> 00:49:04,110
+ال على اربعة في ال تربيعminus L تربيع على أربعة
+
+383
+00:49:04,110 --> 00:49:07,430
+يعني
+
+384
+00:49:07,430 --> 00:49:15,510
+هاخد L تكعيب برا ف L تكعيب على
+
+385
+00:49:15,510 --> 00:49:24,750
+اتنين E I واحد في هذا هتكون اندي تمانية او واحد
+
+386
+00:49:24,750 --> 00:49:28,770
+ناقص تمون سبعة على تمانية يعني هتكون اندي سبعة على
+
+387
+00:49:28,770 --> 00:49:29,750
+أربعة وعشرين
+
+388
+00:49:34,340 --> 00:49:45,160
+ناقص واحد ناقص ربع تلت اربعة تلت اربعة في ربع تلت
+
+389
+00:49:45,160 --> 00:49:53,200
+ع ستاش يعني
+
+390
+00:49:53,200 --> 00:49:57,280
+هيصف اربع و عشرين
+
+391
+00:50:00,010 --> 00:50:13,250
+يعني هيكون عندى fl تكييب على اتنين ei واحد في عندى
+
+392
+00:50:13,250 --> 00:50:17,690
+هيكون تمانية و اربعين تمانية و اربعين على اربع و
+
+393
+00:50:17,690 --> 00:50:26,130
+عشرين اتنين في سبعة اربعتاش ناقص تمانية و اربعين
+
+394
+00:50:26,130 --> 00:50:32,800
+على ستاشتلاتة تلاتة تلاتة تسعة اربتاش ناقص تسعة
+
+395
+00:50:32,800 --> 00:50:45,040
+اللي هي خمسة يعني هتصفي خمسة F L تكييب على ستة
+
+396
+00:50:45,040 --> 00:50:51,080
+وتسعين E I واحد
+
+397
+00:50:52,500 --> 00:50:58,780
+معناة deflection at B اللي هو F A لتا كيب على 96EI
+
+398
+00:50:58,780 --> 00:51:03,020
+اكيد ال deflection at B ارجع للحل قارنه بال
+
+399
+00:51:03,020 --> 00:51:17,800
+deflection at A اكيد عند B هيكون اقل من عند A طيب
+
+400
+00:51:17,800 --> 00:51:20,300
+نكمل
+
+401
+00:51:51,710 --> 00:51:59,810
+هنحل مسألة تانية اكثر تعقيدا فيها تفاصيل اكتر
+
+402
+00:51:59,810 --> 00:52:03,310
+for
+
+403
+00:52:03,310 --> 00:52:08,430
+the wire form of diameter D as shown في عند السلك
+
+404
+00:52:08,430 --> 00:52:14,810
+مشكل بالشكل هذا ومثبت عند الطرف G السلك اللي هو
+
+405
+00:52:14,810 --> 00:52:19,330
+BCDG
+
+406
+00:52:19,330 --> 00:52:26,060
+مثبت عند الطرف Gقطره دي small قطر السلك دي small
+
+407
+00:52:26,060 --> 00:52:30,220
+determine
+
+408
+00:52:30,220 --> 00:52:34,880
+the deflection of point B in the direction of the
+
+409
+00:52:34,880 --> 00:52:39,580
+applied force F أجرى ال deflection عن نقطة B في
+
+410
+00:52:39,580 --> 00:52:43,120
+اتجاه ال force F يعني في اتجاه هذا ال deflection
+
+411
+00:52:43,120 --> 00:52:46,420
+اللي بدى لو بدى ال deflection في هذا الاتجاه لازم
+
+412
+00:52:46,420 --> 00:52:49,540
+أحط force تخيليا Q طيب
+
+413
+00:52:52,670 --> 00:52:58,070
+معطيلي ملاحظة او اشارة بيحكي neglect the effect of
+
+414
+00:52:58,070 --> 00:53:02,470
+transverse shear اهمل تأثير لل transverse shear
+
+415
+00:53:02,470 --> 00:53:06,630
+احنا anyway لو هو ماحكاش كنا هنهمله لان ال effect
+
+416
+00:53:06,630 --> 00:53:11,430
+عه صغير بالمقارنة بال other loading conditions
+
+417
+00:53:11,430 --> 00:53:15,950
+اللي هي سواء كانت bending او axial او torsion
+
+418
+00:53:15,950 --> 00:53:23,030
+هيكون ال effect عه ليس ذو قيمةاللحظ و انا عندى
+
+419
+00:53:23,030 --> 00:53:29,110
+الان different sections يعني بي سي و سي دي و دي جي
+
+420
+00:53:29,110 --> 00:53:34,590
+تلاتة sections each section is loaded differently
+
+421
+00:53:34,590 --> 00:53:37,190
+يعني ال section بي سي ال loading بتاعه مختلف عن ال
+
+422
+00:53:37,190 --> 00:53:42,150
+loading ل سي دي مختلف عن ال loading ل دي جي عشانك
+
+423
+00:53:42,150 --> 00:53:48,010
+انا هجزق المثلة هاخد ل بي سي و سي دي و دي جي و
+
+424
+00:53:48,010 --> 00:53:51,680
+اجمعهمعشان كنت لازم اخد free pedagram for each
+
+425
+00:53:51,680 --> 00:53:58,020
+segment alone اولش هيكون عندى
+
+426
+00:53:58,020 --> 00:54:06,220
+هاخد ال .. اولش ال delta .. ال delta الكل هي delta
+
+427
+00:54:06,220 --> 00:54:18,060
+B هتكون سوى DU by DF ال
+
+428
+00:54:18,060 --> 00:54:26,200
+Uفي عندي ال U for section BC وفي ال U for section
+
+429
+00:54:26,200 --> 00:54:35,400
+CD وفي U for section DJ معناه
+
+430
+00:54:35,400 --> 00:54:49,140
+هتكون بتساوي DU for section BC by DFزائد DU for
+
+431
+00:54:49,140 --> 00:55:02,260
+section CD by DF زائد DU for section DJ by DF هاخد
+
+432
+00:55:02,260 --> 00:55:10,120
+كل واحد لحاله يعني انا ممكن اسمي هذه دلتا
+
+433
+00:55:10,120 --> 00:55:14,000
+واحد او اسميها delta BC
+
+434
+00:55:16,810 --> 00:55:26,570
+delta bc ودلتا cd ودلتا
+
+435
+00:55:26,570 --> 00:55:36,930
+dg لما
+
+436
+00:55:36,930 --> 00:55:42,750
+ناخد free pedagram ل بي سي لحظة انا ممكن انا ممكن
+
+437
+00:55:42,750 --> 00:55:48,240
+ا define xبالطريقة اللي انا بديها او بطريقة انا
+
+438
+00:55:48,240 --> 00:55:52,340
+بحبها لان في الاخر هعمل differential يعني انا عرفت
+
+439
+00:55:52,340 --> 00:55:57,240
+اي define هذه ال X وهي
+
+440
+00:55:57,240 --> 00:56:04,400
+عندى هنا F هنا اكيد هتعكسها force F وهذه هتعمل
+
+441
+00:56:04,400 --> 00:56:09,320
+bending moment يعني هكون عندى bending moment MBC
+
+442
+00:56:13,080 --> 00:56:28,480
+م بي سي بساوي F في X F في X معناه
+
+443
+00:56:28,480 --> 00:56:39,840
+دي م بي سي by دي F بساوي X و I have only bending
+
+444
+00:56:39,840 --> 00:56:57,200
+معناه دلتاBC بالساوية تكامل واحد على EI لل MBC DM
+
+445
+00:56:57,200 --> 00:57:03,900
+BC by DF في DX
+
+446
+00:57:09,940 --> 00:57:16,960
+و ال X دي X بتغيب من صفر ل إيه؟ من صفر ل إيه؟ يعني
+
+447
+00:57:16,960 --> 00:57:28,280
+هيساوي هعوض هطلع واحد على EI تكامل ال MBC FX و دي
+
+448
+00:57:28,280 --> 00:57:36,340
+MBC by DX اللي هي X هصيرها دي في X DX هيساوي هطلع
+
+449
+00:57:36,340 --> 00:57:38,660
+F على EI
+
+450
+00:57:42,410 --> 00:57:47,390
+هيبقى من صفر ل A تكمل X تربيع علي X تكييب على
+
+451
+00:57:47,390 --> 00:57:56,250
+تلاتة هتصير هذه ال H تكملها A تكييب ال Delta بC
+
+452
+00:57:56,250 --> 00:58:01,550
+الان
+
+453
+00:58:01,550 --> 00:58:07,350
+CD هي CD CD
+
+454
+00:58:07,350 --> 00:58:14,140
+and force هي هنا عند B هتعمل torsionهيو تعملي
+
+455
+00:58:14,140 --> 00:58:26,420
+torsion عليه اللي هي ال force بمسافة a اللي
+
+456
+00:58:26,420 --> 00:58:35,160
+هو هذا بي سي اللي هو هذا سي دي هذا هو اللي هتعملي
+
+457
+00:58:35,160 --> 00:58:36,900
+torsion
+
+458
+00:58:38,300 --> 00:58:43,240
+و في كمان bending moment اللي هتكون هذه المسافة X
+
+459
+00:58:43,240 --> 00:58:46,260
+يعني
+
+460
+00:58:46,260 --> 00:58:56,320
+هتكون عندي torsion section BC عندي
+
+461
+00:58:56,320 --> 00:59:03,480
+ال bending moment MCD هتكون هذه المسافة X في ال
+
+462
+00:59:03,480 --> 00:59:13,410
+force F Xو في نتورجين CD اللي هيحبها راح تكون F A
+
+463
+00:59:13,410 --> 00:59:31,650
+F A هيكون عندهان DMCD by DF بالساوية X و D TCD by
+
+464
+00:59:31,650 --> 00:59:34,550
+DF بالساوية A
+
+465
+00:59:39,170 --> 00:59:48,070
+مناعته هيكون الـ Delta CD الـ Delta CD هيكون جزءين
+
+466
+00:59:48,070 --> 00:59:56,470
+جزء due to bending تكامل لواحد
+
+467
+00:59:56,470 --> 01:00:00,850
+على EI لل
+
+468
+01:00:00,850 --> 01:00:12,610
+MCD DMCD by DF DXو ال X تغير من صفر ل بيه طوله بيه
+
+469
+01:00:12,610 --> 01:00:19,710
+من صفر ل بيه زائد
+
+470
+01:00:19,710 --> 01:00:25,110
+تكامل لأن في عندي ال torsion المعادلة نرجع لمعادلة
+
+471
+01:00:25,110 --> 01:00:29,470
+ال torsion ال torsion اللي هي هذه المعادلة
+
+472
+01:00:35,820 --> 01:00:45,740
+ال .. ال .. ال .. ال energy المعادلة الأصلية ال
+
+473
+01:00:45,740 --> 01:00:49,460
+torsion هتكون
+
+474
+01:00:49,460 --> 01:00:57,600
+لما اشتغط هذه بيصير واحد على ج ج
+
+475
+01:00:59,710 --> 01:01:21,870
+فى TCD فى DTCD by DF DX وال X تغير من سفر ل V نبدأ
+
+476
+01:01:21,870 --> 01:01:22,470
+نعوضها
+
+477
+01:01:32,110 --> 01:01:40,530
+يعني انا هكون عندي هنا ال delta CD بتساوي تكامل من
+
+478
+01:01:40,530 --> 01:01:57,870
+0 ل B من 0 ل B ل 1 على EI MCD اللي هي F X و DMCD
+
+479
+01:01:57,870 --> 01:02:07,230
+بقى DF اللي هي XDX زاد التكامل من 0 ل V ل 1 على G
+
+480
+01:02:07,230 --> 01:02:22,370
+J TCD اللي هي F في A في A DX يعني
+
+481
+01:02:22,370 --> 01:02:29,610
+هيكون ساوي F على EI تكامل
+
+482
+01:02:32,680 --> 01:02:40,300
+X تربيع DX من 0 ل B زائد
+
+483
+01:02:40,300 --> 01:02:57,680
+1 على GJ تكامل في F طبعا فA تربيع تكامل DX من 0 ل
+
+484
+01:02:57,680 --> 01:02:57,880
+B
+
+485
+01:03:04,500 --> 01:03:15,160
+يعني هكون F B تكييب على تلاتة EI زائد
+
+486
+01:03:15,160 --> 01:03:29,940
+F A تربيع B على G J هذه ال deflectiondeflection في
+
+487
+01:03:29,940 --> 01:03:42,460
+ال .. due to strain energy in section CD ناخد
+
+488
+01:03:42,460 --> 01:03:48,980
+section DG هاخد انا free pedagram ال section DG ال
+
+489
+01:03:48,980 --> 01:03:53,700
+force دي F هيعكسها force هنا F زي دي حكوا انا اللي
+
+490
+01:03:53,700 --> 01:03:57,260
+عليه bending في مستويين فيه bending في هذا الاتجاه
+
+491
+01:03:58,340 --> 01:04:03,100
+و في بننج في هذا الاتجاه يعني هكون عندى في بننج
+
+492
+01:04:03,100 --> 01:04:08,360
+بيحاول بهذا الاتجاه ايه و في بننج بهذا الاتجاه
+
+493
+01:04:08,360 --> 01:04:12,420
+يعني
+
+494
+01:04:12,420 --> 01:04:16,200
+خلينا نسميها MDG 1 و MDG 2
+
+495
+01:04:29,510 --> 01:04:39,550
+م دي جي واحد هتكون
+
+496
+01:04:39,550 --> 01:04:51,630
+اف في ايه هتعمل بنك بهذا الاتجاه اف في ايه دي
+
+497
+01:04:51,630 --> 01:05:04,220
+م دي جي واحد by ديF هتكون السواش A وم ال DG اتنين
+
+498
+01:05:04,220 --> 01:05:14,800
+هتكون بتحاول تلفها زي هيك هتكون F بي F بي يعني
+
+499
+01:05:14,800 --> 01:05:18,800
+هتكون ال DM DG
+
+500
+01:05:18,800 --> 01:05:28,830
+اتنين by DF هتكون السواش بي معناته ال Deltaالـ
+
+501
+01:05:28,830 --> 01:05:36,690
+delta و في عندى axial force axial force معناته ال
+
+502
+01:05:36,690 --> 01:05:42,850
+delta دي جي هتكون
+
+503
+01:05:42,850 --> 01:05:51,890
+due to this bending تكامل لأن نرجع للشكل على طوله
+
+504
+01:05:51,890 --> 01:05:56,130
+C هكون
+
+505
+01:06:00,480 --> 01:06:08,280
+هيكون تكامل عند ال بنج الأولاني واحد على ei تكامل
+
+506
+01:06:08,280 --> 01:06:27,620
+سفر ل C لل M دي جي واحد في ال DMDG 1 by DF DX زائد
+
+507
+01:06:27,620 --> 01:06:34,960
+التكامل من 0 ل C 1 على EI الاخر بين ال component
+
+508
+01:06:34,960 --> 01:06:52,450
+اللي هي M DG 2فى DMDG 2 by DF فى DX زاد فى ان احنا
+
+509
+01:06:52,450 --> 01:06:56,650
+حكينا ال Axial component Axial component اللى هى
+
+510
+01:06:56,650 --> 01:07:09,770
+هى معدلتها لها دى المعدلة تكامل من 0 ل C 1 على AA
+
+511
+01:07:12,410 --> 01:07:19,110
+فى F فى .. فى ال .. فى F فى
+
+512
+01:07:19,110 --> 01:07:29,850
+DF by DF DX اه نبدأ نحل ال integral هيكون يساوي
+
+513
+01:07:29,850 --> 01:07:33,550
+واحد
+
+514
+01:07:33,550 --> 01:07:38,130
+على EI تكامل من صفر لل C
+
+515
+01:07:47,510 --> 01:07:54,710
+الـ MDG 1 حكينا F A و
+
+516
+01:07:54,710 --> 01:08:04,570
+DMG 1 بديها في اللي هي A DX زي التكامل من 0 ل C
+
+517
+01:08:04,570 --> 01:08:15,390
+طبعا 1 على AI بتطلع برا MDG 2 اللي هي FB و
+
+518
+01:08:15,390 --> 01:08:22,760
+DMG 2by df بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+519
+01:08:22,760 --> 01:08:22,820
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+520
+01:08:22,820 --> 01:08:26,180
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+521
+01:08:26,180 --> 01:08:31,140
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+522
+01:08:31,140 --> 01:08:31,160
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+523
+01:08:31,160 --> 01:08:31,160
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+524
+01:08:31,160 --> 01:08:36,840
+بي بي بي بي بي بي بي بي بي بي بي
+
+525
+01:08:36,840 --> 01:08:44,900
+بي
+
+526
+01:08:44,900 --> 01:08:54,620
+بأول تكامل هذا عبارة عن F A تربيع في C F A تربيع
+
+527
+01:08:54,620 --> 01:09:01,260
+في C على EI زاد
+
+528
+01:09:01,260 --> 01:09:14,200
+F B تربيع C على EI زاد
+
+529
+01:09:18,900 --> 01:09:26,100
+Fc على a في a لان
+
+530
+01:09:26,100 --> 01:09:30,240
+خلينا نجمع احنا اكيدنا ال deflection at b عبارة عن
+
+531
+01:09:30,240 --> 01:09:33,640
+deflection for section bc زي ال deflection for
+
+532
+01:09:33,640 --> 01:09:38,980
+section cd زي ال deflection for section dg معناته
+
+533
+01:09:38,980 --> 01:09:41,200
+ال delta ال كلية delta b
+
+534
+01:09:45,670 --> 01:09:50,970
+دلتا بي الكلية هتكون
+
+535
+01:09:50,970 --> 01:09:57,490
+اول واحدة دلتا بي C طلعت معنا F على
+
+536
+01:09:57,490 --> 01:10:06,430
+تلاتة EI في A تكييبة هاي اول واحدة زاد ال
+
+537
+01:10:06,430 --> 01:10:10,210
+deflection due to C دي هي F بي تكييب
+
+538
+01:10:15,040 --> 01:10:25,940
+على تلاتة EI اللي هي هذا ال term زاد F A تربيع B
+
+539
+01:10:25,940 --> 01:10:33,240
+على G في J ال
+
+540
+01:10:33,240 --> 01:10:42,300
+term التالت اللي هو delta DG اللي هو هذا زاد F A
+
+541
+01:10:42,300 --> 01:11:01,200
+تربيع Cعلى EI زائد FB تربيع C على EI زائد FC على A
+
+542
+01:11:01,200 --> 01:11:09,820
+في A هيك
+
+543
+01:11:09,820 --> 01:11:18,380
+حسبنا deflection عن نقطة Bطبعا ممكن تكمل اكتر الان
+
+544
+01:11:18,380 --> 01:11:22,860
+فينا اللي هو ان ال I و ال J و ال A ال A ايش
+
+545
+01:11:22,860 --> 01:11:32,420
+بالساوية باي على اربعة دي التربية و ال I باي على
+
+546
+01:11:32,420 --> 01:11:42,060
+اربعة و ستين دي قصة اربعة و ال J بالساوية باي على
+
+547
+01:11:42,060 --> 01:11:42,940
+اتنين و تلاتين
+
+548
+01:11:45,620 --> 01:11:51,240
+D أص أربعة D
+
+549
+01:11:51,240 --> 01:11:56,960
+أص أربعة و
+
+550
+01:11:56,960 --> 01:12:04,480
+في علاقة بين ال E و ال G من خلال Pies ratio في
+
+551
+01:12:04,480 --> 01:12:06,540
+علاقة بين ال E و ال G من خلال ال Pies ratio ممكن
+
+552
+01:12:06,540 --> 01:12:11,960
+تبسطه و تخلوها بدلالة ال E كلها او بدلالة ال G
+
+553
+01:12:15,400 --> 01:12:19,660
+يعني ممكن تعمل more simplification بس ال .. ال ..
+
+554
+01:12:19,660 --> 01:12:23,900
+ال .. ال main body للمثلة حالناها و بعدين بيصير
+
+555
+01:12:23,900 --> 01:12:32,040
+الشغل شبر و تبسيط و بس يعني .. يعني ممكن يعملوا
+
+556
+01:12:32,040 --> 01:12:38,100
+طلاب أول سنة و تانية سنة ممكن يشتغلوا الشغل زي هيك
+
+557
+01:12:49,860 --> 01:12:54,360
+طيب المرة الجاية بنكمل ال deflection of cared
+
+558
+01:12:54,360 --> 01:13:02,080
+members بعدين هنشوف كيف نحل مسائل غير قابلة للحال
+
+559
+01:13:02,080 --> 01:13:05,420
+باستخدام طرق الاستاتيكا التقليدية
+
+560
+01:13:11,010 --> 01:13:13,950
+اللي هو aesthetically indeterminate problems بعدين
+
+561
+01:13:13,950 --> 01:13:17,830
+ال buckling of compression columns تاكيه نكون
+
+562
+01:13:17,830 --> 01:13:22,090
+خلصنا chapter أربعة طبعا chapter تلاتة و أربعة
+
+563
+01:13:22,090 --> 01:13:27,310
+كانت تحضير و تهيئة لل .. لل judges الأساسي في
+
+564
+01:13:27,310 --> 01:13:31,030
+المادة اللي هي design for aesthetic او aesthetic
+
+565
+01:13:31,030 --> 01:13:34,690
+design و عندنا fatigue design او design for
+
+566
+01:13:34,690 --> 01:13:38,160
+dynamic loadingو فينا design for static loading
+
+567
+01:13:38,160 --> 01:13:42,580
+chapter تلاتة وأربعة تجهيز و تحضير لهدول ال two
+
+568
+01:13:42,580 --> 01:13:47,780
+chapters اللي هو مثله اللي هو قلب المادة
+
diff --git a/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/BohkPcY7GQQ.srt b/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/BohkPcY7GQQ.srt
new file mode 100644
index 0000000000000000000000000000000000000000..b3b530d5cb1396bdc8836856005fdbdfe66b2b63
--- /dev/null
+++ b/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/BohkPcY7GQQ.srt
@@ -0,0 +1,1651 @@
+1
+00:00:05,150 --> 00:00:11,390
+السلام عليكم، المرة اللي فاتت حكينا عن كيفية حساب
+
+2
+00:00:11,390 --> 00:00:14,430
+الـ fatigue stress concentration factor، حكينا كيف
+
+3
+00:00:14,430 --> 00:00:23,770
+نحسبه،  KF = 1 + Q(Kt - 1) ، الـ Kt
+
+4
+00:00:23,770 --> 00:00:26,470
+هو الـ geometric stress concentration factor، والـ
+
+5
+00:00:26,470 --> 00:00:29,870
+Q هو الـ notch sensitivity factor،  بنحسبه من شكل
+
+6
+00:00:29,870 --> 00:00:34,080
+26 وشكل 6-11  والـ Kt  هي من
+
+7
+00:00:34,080 --> 00:00:39,020
+appendix A9، بتحسب حسب طبيعة الـ loading  وحسب طبيعة الـ
+
+8
+00:00:39,020 --> 00:00:43,020
+geometry للـ mechanical part. الآن السؤال اليوم: how
+
+9
+00:00:43,020 --> 00:00:47,980
+to apply fatigue stress concentration factor، الآن
+
+10
+00:00:47,980 --> 00:00:51,920
+نستخدم KF كعامل ضرب لزيادة الإجهاد الاسمي،
+
+11
+00:00:51,920 --> 00:00:58,410
+يعني أنا حسبت الـ nominal stress، σ  مثلاً 100، والـ KF
+
+12
+00:00:58,410 --> 00:01:03,470
+حسبته طالع عندي مثلاً 1.8، هضرب...
+
+13
+00:01:03,470 --> 00:01:09,970
+هضرب KF × σo = 1.8 × 100
+
+14
+00:01:09,970 --> 00:01:16,390
+هيكون عندي 180. بعض
+
+15
+00:01:16,390 --> 00:01:22,530
+المصممين بيقولوا لي endurance strength، بيقسمولي  SE أو
+
+16
+00:01:22,530 --> 00:01:26,790
+أو بيقول لي SE على
+
+17
+00:01:28,610 --> 00:01:34,110
+كيف، إما بترفع الـ stress level أو بتنزل الـ
+
+18
+00:01:34,110 --> 00:01:38,130
+endurance limit. يعني ممكن نستخدمه as a multiplier
+
+19
+00:01:38,130 --> 00:01:43,090
+أو as a reduction، في الحالة دي، for infinite life
+
+20
+00:01:43,090 --> 00:01:47,790
+For infinite life،  Nf = SE × kf /
+
+21
+00:01:47,790 --> 00:01:51,700
+σ،  الـ kf × σ عبارة عن multiplier، أنا برفع
+
+22
+00:01:51,700 --> 00:01:55,680
+الـ stress، أو بقول واحد على kf × SE، reducer، إن الـ kf
+
+23
+00:01:55,680 --> 00:02:02,600
+استخدمته عشان أُقلل الـ endurance limit، هذا في حالة
+
+24
+00:02:02,600 --> 00:02:07,480
+infinite life. For finite life،  حالة finite life،
+
+25
+00:02:07,480 --> 00:02:11,680
+زيادة الإجهاد  is more conservative، أنه أرفع الـ
+
+26
+00:02:11,680 --> 00:02:17,160
+stress بيعطيني نتائج محافظة أكثر، يعني يعني أنصر
+
+27
+00:02:17,160 --> 00:02:21,160
+المخاطرة في الحسابات بتاعتي بيكون أقل. Decreasing SF
+
+28
+00:02:21,160 --> 00:02:27,420
+applies more to high cycle than low cycle fatigue.
+
+29
+00:02:27,420 --> 00:02:29,660
+نشوف example.
+
+30
+00:02:37,220 --> 00:02:40,960
+For the step shaft of example 6-6، احنا كانت في
+
+31
+00:02:40,960 --> 00:02:45,580
+الـ exam 6-6، عندي step shaft،
+
+32
+00:02:45,580 --> 00:03:03,440
+هذه
+
+33
+00:03:03,440 --> 00:03:23,500
+كانت فكرة هي كراسة مغلطة، ها
+
+34
+00:03:23,500 --> 00:03:29,380
+step shaft، الـ exhaust  ستكونها دي 23
+
+35
+00:03:29,380 --> 00:03:41,730
+مم، وهذا  D=30 مم، وهذا  D=38 مم، it
+
+36
+00:03:41,730 --> 00:03:46,290
+is
+
+37
+00:03:46,290 --> 00:03:48,750
+It is determined that the fully corrected
+
+38
+00:03:48,750 --> 00:03:54,330
+endurance limit، SE، fully corrected، يعني أنا
+
+39
+00:03:54,330 --> 00:03:58,590
+أخذت بعين الاعتبار الـ modification factors، KA، KB، KC، KD،
+
+40
+00:03:58,590 --> 00:04:09,220
+KE، KF،  بـ 80 ميجاباسكال. Consider
+
+41
+00:04:09,220 --> 00:04:13,680
+the shaft undergoing a fully reversed nominal
+
+42
+00:04:13,680 --> 00:04:21,460
+stress، σr (nominal)، هسميها σo،  هو
+
+43
+00:04:21,460 --> 00:04:29,780
+260 ميجاباسكال. Estimate the number of
+
+44
+00:04:29,780 --> 00:04:31,580
+cycles to failure.
+
+45
+00:04:35,330 --> 00:04:39,790
+الآن، هذا الـ nominal stress without stress without
+
+46
+00:04:39,790 --> 00:04:45,050
+stress concentration. إذا فاكرين من example السابق،
+
+47
+00:04:45,050 --> 00:04:50,850
+أنا حسبت الـ KF =
+
+48
+00:04:50,850 --> 00:04:57,810
+احنا حسبنا الـ KF،
+
+49
+00:05:02,160 --> 00:05:08,280
+أظن أنه 1.65، هنا مطلوب أنكم تتأكدوا،
+
+50
+00:05:08,280 --> 00:05:12,900
+تأكدوا، ارجعوا للفيديو، تأكدوا من القيمة هذه، أفرض
+
+51
+00:05:12,900 --> 00:05:20,140
+هنا KF = 1.65، معناته الـ σ هتكون
+
+52
+00:05:20,140 --> 00:05:25,300
+KF ×
+
+53
+00:05:25,300 --> 00:05:45,880
+σr (nominal)، يعني هيكون 1.65 × 260، تطلع
+
+54
+00:05:45,880 --> 00:05:51,180
+429 ميجا
+
+55
+00:05:51,180 --> 00:05:57,380
+باسكال. الـ SUT كان معطيني إياها في الـ exam السابق، الـ
+
+56
+00:05:57,380 --> 00:05:57,920
+SUT،
+
+57
+00:06:04,160 --> 00:06:12,080
+كان معطينا الـ SUT = 690 ميجاباسكال، 690 ميجاباسكال.
+
+58
+00:06:12,080 --> 00:06:19,340
+لاحظوا،
+
+59
+00:06:19,340 --> 00:06:26,160
+الـ σr أكبر
+
+60
+00:06:26,160 --> 00:06:31,520
+من الـ endurance limit، وأصغر من الـ tensile strength.
+
+61
+00:06:33,340 --> 00:06:37,740
+ما زالت أكبر من الـ SE،
+
+62
+00:06:37,740 --> 00:06:47,000
+معناته we have infinite life.  σr أكبر
+
+63
+00:06:47,000 --> 00:06:56,920
+من الـ SE وأصغر من الـ SUT، معناته we have finite
+
+64
+00:06:56,920 --> 00:07:00,440
+life.
+
+65
+00:07:05,100 --> 00:07:10,480
+ما زال finite life، هنستخدم المعادلات اللي هي في
+
+66
+00:07:10,480 --> 00:07:17,580
+المحاضرة السابقة، اللي هي finite
+
+67
+00:07:17,580 --> 00:07:18,140
+life.
+
+68
+00:07:40,650 --> 00:07:45,090
+آه، اللي هي المعادلة 6-13، نحسب الـ SF، نحسب
+
+69
+00:07:45,090 --> 00:07:51,510
+SF =
+
+70
+00:07:51,510 --> 00:07:58,970
+A × N^B، والـ
+
+71
+00:07:58,970 --> 00:08:11,420
+A = (SUT)^2 / SA، والـ B = -1/3 log[(SUT)/SA]
+
+72
+00:08:11,420 --> 00:08:25,480
+الـ  B = -1/3 log[(SUT)/SA]. الآن واضح أن
+
+73
+00:08:25,480 --> 00:08:32,940
+أنا محتاج الـ F، الـ F من هنا بنحسبها من
+
+74
+00:08:32,940 --> 00:08:39,700
+figure 6-18، figure 6-18.
+
+75
+00:08:44,300 --> 00:08:54,160
+الـ 690 ميجاباسكال، حوالي 100 كيلوبااسكال،
+
+76
+00:08:54,160 --> 00:08:59,380
+690 كيلو باسكال،  بالـ English unit بتساوي 100
+
+77
+00:08:59,380 --> 00:09:07,540
+كيلو pound per square inch، عند 100 عشان أحسب الـ F
+
+78
+00:09:07,540 --> 00:09:10,940
+من figure 6-18،  هاي الـ 100،
+
+79
+00:09:27,940 --> 00:09:41,920
+الـ F يعني،
+
+80
+00:09:41,920 --> 00:09:49,600
+ممكن أقول 8.45، تطلع الـ F ≈
+
+81
+00:09:49,600 --> 00:09:51,700
+8.45
+
+82
+00:09:53,610 --> 00:10:00,930
+من figure 6-18، وأنا هبقى أحسب الـ A،
+
+83
+00:10:00,930 --> 00:10:08,930
+هنا نحسب  8.45 × 690
+
+84
+00:10:08,930 --> 00:10:20,510
+^2 / SE، SE اللي هي 80، وأنا
+
+85
+00:10:20,510 --> 00:10:30,450
+بحسب الـ A، الـ B هتكون = -1/3 log[(F
+
+86
+00:10:30,450 --> 00:10:36,690
+اللي هي 8.45 × 690) /
+
+87
+00:10:36,690 --> 00:10:38,530
+الـ 80،
+
+88
+00:11:00,600 --> 00:11:09,580
+تطلع 1214، والـ
+
+89
+00:11:09,580 --> 00:11:23,160
+B =
+
+90
+00:11:23,160 --> 00:11:24,740
+0.845،
+
+91
+00:11:44,610 --> 00:11:50,570
+تقسيم 3، تطلع -
+
+92
+00:11:50,570 --> 00:11:54,670
+0.
+
+93
+00:11:54,670 --> 00:12:00,030
+1062
+
+94
+00:12:15,440 --> 00:12:27,180
+الآن، الآن، N = σr / A^
+
+95
+00:12:27,180 --> 00:12:31,520
+(1/B)، يعني هيساوي σr، يعني حسبناها
+
+96
+00:12:31,520 --> 00:12:34,360
+بعد applying اللي هو الـ stress fatigue
+
+97
+00:12:34,360 --> 00:12:39,080
+stress concentration factor، 429
+
+98
+00:12:39,080 --> 00:12:48,990
+/ 1214 ^ (1 /
+
+99
+00:12:48,990 --> 00:12:58,690
+-0.1062)، 429
+
+100
+00:12:58,690 --> 00:13:07,430
+و29 / 1214 = 10^
+
+101
+00:13:11,030 --> 00:13:19,870
+1/-0.1062،
+
+102
+00:13:19,870 --> 00:13:27,690
+تطلع 17942 cycle، يعني الـ shaft هذا هيلف
+
+103
+00:13:27,690 --> 00:13:33,190
+17942 لفة، وبعدين
+
+104
+00:13:33,190 --> 00:13:37,450
+هيصير الـ failure.
+
+105
+00:13:37,450 --> 00:13:38,050
+هيحدث الـ failure.
+
+106
+00:13:59,550 --> 00:14:05,230
+طيب، هيك احنا حسبنا الـ number of cycles to failure، نشوف
+
+107
+00:14:05,230 --> 00:14:26,890
+مثال تاني، مثال 6-8، طيب
+
+108
+00:14:29,720 --> 00:14:33,060
+A 1015 hot rolled steel، الـ material بتاعت
+
+109
+00:14:33,060 --> 00:14:40,240
+الـ bar، الـ material بتاعته 1015
+
+110
+00:14:40,240 --> 00:14:50,160
+hot rolled steel، حديد كربون 0.15،
+
+111
+00:14:50,160 --> 00:14:55,180
+و مسحوب على الساخن، has been machined to a
+
+112
+00:14:55,180 --> 00:15:05,360
+diameter of one inch، القطر بتاع الـ shaft واحد إنش، it
+
+113
+00:15:05,360 --> 00:15:09,520
+is to be placed in a reversed axial loading for
+
+114
+00:15:09,520 --> 00:15:13,200
+70,000 cycles. الآن number of cycles،
+
+115
+00:15:13,200 --> 00:15:16,260
+70
+
+116
+00:15:16,260 --> 00:15:20,880
+ألف، to
+
+117
+00:15:20,880 --> 00:15:25,160
+failure in an operating environment of 550 و
+
+118
+00:15:25,160 --> 00:15:30,600
+50 Fahrenheit، درجة الحرارة 550 و 50
+
+119
+00:15:30,600 --> 00:15:37,540
+degrees Fahrenheit، using
+
+120
+00:15:37,540 --> 00:15:42,160
+ASTM minimum properties and a reliability of
+
+121
+00:15:42,160 --> 00:15:46,960
+99 percent، الـ R = 99%.
+
+122
+00:15:46,960 --> 00:15:50,640
+Estimate
+
+123
+00:15:50,640 --> 00:15:56,660
+the endurance limit and fatigue strength at، يعني
+
+124
+00:15:56,660 --> 00:15:57,800
+بدنا نحسب الـ SE
+
+125
+00:16:01,100 --> 00:16:04,980
+والـ SF، SFN،
+
+126
+00:16:04,980 --> 00:16:09,000
+أول
+
+127
+00:16:09,000 --> 00:16:13,360
+شيء، مثال زي هيك بدي أطلع الخواص الميكانيكية للمعدن
+
+128
+00:16:13,360 --> 00:16:19,580
+هذا، هروح على الجدول، هروح على جدول A-20 في شجرتنا، هروح
+
+129
+00:16:19,580 --> 00:16:20,680
+على جدول A-20.
+
+130
+00:16:32,740 --> 00:16:38,580
+هذا A-20، A-20 دي hot rolled steel، 10
+
+131
+00:16:38,580 --> 00:16:46,580
+و 15، اللي هو هذا، هذا 1015 hot rolled،
+
+132
+00:16:46,580 --> 00:16:52,320
+معطيني هذه الـ tensile strength، هذه الـ yield
+
+133
+00:16:52,320 --> 00:17:03,050
+strength، الـ... الـ tensile strength، 50 كيلو
+
+134
+00:17:03,050 --> 00:17:10,970
+pound per square inch، الـ SUT = 50
+
+135
+00:17:10,970 --> 00:17:21,410
+كيلو pound per square inch، خليني أكبرها شوية،
+
+136
+00:17:21,410 --> 00:17:27,190
+هاي،
+
+137
+00:17:27,190 --> 00:17:27,390
+ها،
+
+138
+00:17:30,280 --> 00:17:38,700
+وهذا الـ yield strength، والـ SY =
+
+139
+00:17:38,700 --> 00:17:43,900
+75 كيلو pound per square inch.
+
+140
+00:18:05,760 --> 00:18:12,100
+طيب، هذا الـ table A-20.
+
+141
+00:18:12,100 --> 00:18:18,140
+أول
+
+142
+00:18:18,140 --> 00:18:24,880
+شيء، هحسب الـ SA prime، اللي هي الـ SA prime هتكون = 0.5
+
+143
+00:18:24,880 --> 00:18:27,320
+الـ SUT،
+
+144
+00:18:30,610 --> 00:18:37,970
+= 0.5 × 50 = 25 كيلو pound per square
+
+145
+00:18:37,970 --> 00:18:44,930
+inch. الـ SE هتكون
+
+146
+00:18:44,930 --> 00:18:57,270
+KA KB KC KD KE KF × SE prime. الـ SE Prime
+
+147
+00:18:57,270 --> 00:18:59,870
+already  حصلت لـ 25%، الـ KA اللي هو الـ service
+
+148
+00:18:59,870 --> 00:19:00,930
+finish factor
+
+149
+00:19:30,450 --> 00:19:38,730
+الـ KA =
+
+150
+00:19:38,730 --> 00:19:45,550
+A × (SUT)^A ، أنا
+
+151
+00:19:45,550 --> 00:19:49,610
+عندي hot rolled، هاي hot rolled، والوحدات اللي هي
+
+152
+00:19:49,610 --> 00:19:54,630
+إنجليزية، معناته هتكون عندي الـ A
+
+153
+00:20:01,390 --> 00:20:12,490
+بتساوي 0.44، والـ
+
+154
+00:20:12,490 --> 00:20:23,810
+B = -0.718، من
+
+155
+00:20:23,810 --> 00:20:33,470
+table 6-2. هدول table 6-2، معناته يعني الـ
+
+156
+00:20:33,470 --> 00:20:38,650
+KA هيكون = 0.44 ×
+
+157
+00:20:38,650 --> 00:20:44,950
+50^-0.718،
+
+158
+00:21:17,190 --> 00:21:26,490
+فيطلع 0.868، 0.868،
+
+159
+00:21:26,490 --> 00:21:35,130
+الـ KB، الـ
+
+160
+00:21:35,130 --> 00:21:41,130
+size factor، الـ KB هيكون
+
+161
+00:21:41,130 --> 00:21:41,670
+=
+
+162
+00:21:45,670 --> 00:21:54,150
+0.879 × d
+
+163
+00:21:54,150 --> 00:22:01,290
+^-0.107، هيساوي 0.879 × d،
+
+164
+00:22:01,290 --> 00:22:06,790
+اللي هي 1، ^-0.107،
+
+165
+00:22:06,790 --> 00:22:07,570
+0.107.
+
+166
+00:22:15,180 --> 00:22:31,540
+1 ^ 1،
+
+167
+00:22:31,540 --> 00:22:40,820
+يعني هتكون 0.879، هذا
+
+168
+00:22:40,820 --> 00:22:41,320
+الـ KB،
+
+169
+00:22:53,760 --> 00:23:02,980
+الآن، هو قال لي it is under، الـ KC هتكون
+
+170
+00:23:02,980 --> 00:23:05,860
+= 0.85، لأنه under 0.85،
+
+171
+00:23:05,860 --> 00:23:14,500
+completely reversed
+
+172
+00:23:14,500 --> 00:23:18,000
+axial loading،
+
+173
+00:23:22,090 --> 00:23:26,170
+لأن بالنسبة لـ KD اللي هي الـ factor بتاع الحرارة،
+
+174
+00:23:26,170 --> 00:23:31,550
+الحرارة عندي 550 فهرنهايت، يعني هيكون
+
+175
+00:23:31,550 --> 00:23:39,330
+هنا معناته
+
+176
+00:23:39,330 --> 00:23:47,230
+الـ KD أو الـ KD هيكون
+
+177
+00:23:47,230 --> 00:23:50,650
+= الـ average value اللي هو 0.995،
+
+178
+00:23:53,290 --> 00:24:16,330
++ 0.963 / 2، بيطلع
+
+179
+00:24:16,330 --> 00:24:21,210
+0.979،
+
+180
+00:24:23,720 --> 00:24:27,800
+الـ reliability عندي 99%، هروح أحسب
+
+181
+00:24:27,800 --> 00:24:34,120
+الـ KE، 99
+
+182
+00:24:34,120 --> 00:24:38,900
+في المئة، 99
+
+183
+00:24:38,900 --> 00:24:43,220
+في المئة هتكون
+
+184
+00:24:43,220 --> 00:24:44,540
+الـ KE
+
+185
+00:24:51,010 --> 00:24:57,490
+= 0.814، معناته
+
+186
+00:24:57,490 --> 00:25:03,510
+هنا أنا هحسب الـ SE، KA أنا already حسبتها اللي هي
+
+187
+00:25:03,510 --> 00:25:13,850
+0.868 × KB = 0.879 ×
+
+188
+00:25:13,850 --> 00:25:25,050
+KC = 0.85 × KD = 0.979
+
+189
+00:25:25,050 --> 00:25:33,130
+× KE = 0.814 × 25،
+
+190
+00:26:07,180 --> 00:26:21,000
+تطلع 12.92،
+
+223
+00:32:17,370 --> 00:32:24,090
+مثال ثالث the figure shows a rotating shaft عندي ال
+
+224
+00:32:24,090 --> 00:32:30,370
+figure مبين دي shaft عمود دوار simply supported in
+
+225
+00:32:30,370 --> 00:32:36,630
+ball bearings at a and d بلي عند a و بلي عند d
+
+226
+00:32:36,630 --> 00:32:41,730
+يعني هذه a وهذه
+
+227
+00:32:41,730 --> 00:32:47,310
+d at
+
+228
+00:32:47,310 --> 00:32:53,630
+a and d and loaded by a non-rotating force F قيمة 6
+
+229
+00:32:53,630 --> 00:32:59,090
+.8 كيلونيوتن force F قيمة
+
+230
+00:32:59,090 --> 00:33:08,450
+6.8 كيلونيوتن using
+
+231
+00:33:08,450 --> 00:33:14,030
+ASTM minimum
+
+232
+00:33:14,030 --> 00:33:18,780
+strength; estimate the life of the part احسب ال life
+
+233
+00:33:18,780 --> 00:33:34,300
+بتاعة ال part يعني أنك تحسب ال a طب
+
+234
+00:33:34,300 --> 00:33:39,960
+هين المفروض يعطيني ال material بتاعة ال
+
+235
+00:33:39,960 --> 00:33:43,300
+shaft هنروح نشوف ايش ال material بتاعة ال shaft
+
+236
+00:33:43,300 --> 00:33:47,410
+المفروض معطينيها في ال example في الكتاب
+
+237
+00:34:21,890 --> 00:34:26,750
+آه هو مفترض ال material مفترض أن ال SUT عنده ستمية
+
+238
+00:34:26,750 --> 00:34:29,510
+و تسعين ميجا باسكال والـ SY خمسمية وثمانية ميجا
+
+239
+00:34:29,510 --> 00:34:34,610
+باسكال ال SUT هذا اللي هو المفروض يكون معطوه ال
+
+240
+00:34:34,610 --> 00:34:42,050
+SUT ستمية وتسعين ميجا باسكال وخمسمية وثمانية
+
+241
+00:34:42,050 --> 00:34:47,790
+ستمية وتسعين ميجا باسكال والـ SY
+
+242
+00:34:52,190 --> 00:34:57,710
+خمسمية وثمانين ميجا باسكال كان في حال مثال زي هيك
+
+243
+00:34:57,710 --> 00:35:04,590
+أول شيء لازم نعمل ما يسمى ال ...
+
+244
+00:35:04,590 --> 00:35:10,510
+نحسب ال reactions عند a و d بعدين نرسم ال shear
+
+245
+00:35:10,510 --> 00:35:16,630
+diagram و ال moment diagram بعدين specify ال
+
+246
+00:35:16,630 --> 00:35:22,050
+critical locations while taking care of stress
+
+247
+00:35:22,050 --> 00:35:25,690
+concentrations وهنا احنا هنبدأ في التسلسل أول شيء
+
+248
+00:35:25,690 --> 00:35:29,150
+calculate reactions عشان to calculate reactions I
+
+249
+00:35:29,150 --> 00:35:33,650
+have to make a free body diagram بدي أعمل free
+
+250
+00:35:33,650 --> 00:35:39,650
+body diagram أو عندي ... عندي هذه A وهذه
+
+251
+00:35:39,650 --> 00:35:48,150
+D عندي هذه 6.8 كيلو نيوتن ده أحسب ال reactions عندي
+
+252
+00:35:48,150 --> 00:35:51,150
+a و d ده أحسب R واحد و R اتنين هاخد summation of
+
+253
+00:35:51,150 --> 00:35:59,510
+moment summation of moment عندي بالساوية صفر هعتبر
+
+254
+00:35:59,510 --> 00:36:08,610
+بعكس عقارب الساعة موجب هيكون ساوة هيكون عندي هنا ستة
+
+255
+00:36:08,610 --> 00:36:11,590
+point تمانية في مئة زائد مئة وخمس وعشرين يعني
+
+256
+00:36:11,590 --> 00:36:13,330
+ميتين وخمس وعشرين 6.8 point
+
+257
+00:36:17,570 --> 00:36:22,550
+في ميتين وخمس وعشرين ناقص عند ال R واحد في
+
+258
+00:36:22,550 --> 00:36:29,490
+المسافة هذه عند مئة
+
+259
+00:36:29,490 --> 00:36:32,750
+زي مئة وخمس وعشرين ميتين وخمس وعشرين زي خمسة
+
+260
+00:36:32,750 --> 00:36:41,470
+و سبعين تلات مية زي ميتين وخمسين كمان والله 125 225
+
+261
+00:36:41,470 --> 00:36:57,410
+300 زائد 250 550 ناقص 550 في R1 ومنها
+
+262
+00:36:57,410 --> 00:37:01,950
+بحسب ال R1 هتكون
+
+263
+00:37:03,790 --> 00:37:12,990
+6.8 في 225 تقسم تطلع
+
+264
+00:37:12,990 --> 00:37:21,150
+2.781 كيلو
+
+265
+00:37:21,150 --> 00:37:22,490
+نيوتن
+
+266
+00:37:25,300 --> 00:37:32,560
+هحكي summation لل FY بالساوية 0 هيكون الساوية R1
+
+267
+00:37:32,560 --> 00:37:42,260
+زائد R2 ناقص 6.8 ومنها بحسب ال R2 هتكون 6.8 ناقص
+
+268
+00:37:42,260 --> 00:37:44,200
+2.781
+
+269
+00:37:59,490 --> 00:38:08,490
+بتطلع أربعة point أو تسعة عشر خلي
+
+270
+00:38:08,490 --> 00:38:12,030
+هذا بالنيوتن يعني هتكون أربعة آلاف وسبعمية وثمانية عشر
+
+271
+00:38:12,030 --> 00:38:19,650
+نيوتن هذا هتكون أربعة آلاف وتسعة عشر نيوتن حسبت R
+
+272
+00:38:19,650 --> 00:38:24,050
+واحد و R اتنين هعمل ال ... ال shear و ال moment
+
+273
+00:38:24,050 --> 00:38:25,570
+diagram ال shear diagram
+
+274
+00:38:46,520 --> 00:38:54,320
+الشير دياجرام أنا
+
+275
+00:38:54,320 --> 00:39:06,800
+عند ال R1 اللي هي 2781 هيكون شكل
+
+276
+00:39:06,800 --> 00:39:07,500
+الشير دياجرام
+
+277
+00:39:20,590 --> 00:39:28,770
+هذا الشير عنده هنا
+
+278
+00:39:28,770 --> 00:39:37,350
+ألفين وسبعمية وواحد وثمانين وهنا ناقص أربعة
+
+279
+00:39:37,350 --> 00:39:45,690
+آلاف وتسعة عشر ال moment diagram هيكون
+
+280
+00:39:45,690 --> 00:39:46,710
+جاي بالشكل هذا
+
+281
+00:39:55,490 --> 00:40:00,610
+عندي هذه هتكون
+
+282
+00:40:00,610 --> 00:40:03,370
+ال area هذه ال area اللي هي هتكون ألفين هذه
+
+283
+00:40:03,370 --> 00:40:09,510
+المسافة ميتين وخمسين زائد خمسين تلات مية وخمس وعشرين
+
+284
+00:40:09,510 --> 00:40:11,030
+يعني هذه هتكون
+
+285
+00:40:18,710 --> 00:40:22,890
+ألف في هنا سبعة مئة وواحد وثمانين في تلات مية وخمس وعشرين
+
+286
+00:40:22,890 --> 00:40:30,390
+تقسيم ألف تطلع
+
+287
+00:40:30,390 --> 00:40:34,850
+تسعمئة وثلاثة point تسعمئة وثلاثة point أو
+
+288
+00:40:34,850 --> 00:40:40,730
+تسعمئة وأربعة نحكي تسعمئة وأربعة نيوتن
+
+289
+00:40:40,730 --> 00:40:43,850
+متر هذا ال moment diagram
+
+290
+00:40:47,940 --> 00:40:52,900
+الـ moment diagram الآن
+
+291
+00:40:52,900 --> 00:41:04,300
+السؤال لحظة القطر هنا عندي القطر هنا 32 والقطر
+
+292
+00:41:04,300 --> 00:41:15,020
+هنا 38 والقطر هنا 35 الآن
+
+293
+00:41:15,020 --> 00:41:23,740
+في عندي نقطة B ونقطة C لأن القطر صح ال moment هنا
+
+294
+00:41:23,740 --> 00:41:28,040
+maximum لكن عند النقطة هذه مافيش stress
+
+295
+00:41:28,040 --> 00:41:33,400
+concentration الآن معناته ال critical point هتكون
+
+296
+00:41:33,400 --> 00:41:40,440
+يا إما B يا إما C لأن في شغل ثاني عند B القطر أصغر
+
+297
+00:41:40,440 --> 00:41:45,850
+من القطر C معناته من ناحية القطر هتكون B is more
+
+298
+00:41:45,850 --> 00:41:53,270
+critical than C بعدين عندك هنا B أقرب على ال load
+
+299
+00:41:53,270 --> 00:41:56,930
+معناته ال moment هنا هتكون أعلى عن B يعني أنت عند
+
+300
+00:41:56,930 --> 00:42:01,770
+B القطر أصغر وال moment أعلى معناته ال critical
+
+301
+00:42:01,770 --> 00:42:10,630
+point هي نقطة B معناته أنا لازم أنزل هنا وأحسب ال moment at B بمعنى
+
+302
+00:42:10,630 --> 00:42:19,610
+أحسب ال moment at B بمعنى بي
+
+303
+00:42:19,610 --> 00:42:27,930
+is the critical location at
+
+304
+00:42:27,930 --> 00:42:32,230
+B
+
+305
+00:42:32,230 --> 00:42:43,330
+وال moment عن B هتكون هعمل تشابه مثلثات هذه
+
+306
+00:42:43,330 --> 00:42:53,130
+مع هذه المسافة كم؟ هذه ميتين وخمسين ميتين
+
+307
+00:42:53,130 --> 00:42:58,690
+وخمسين وهذه كلها تلات مية وخمس وعشرين هذه كلها
+
+308
+00:42:58,690 --> 00:43:01,990
+تلات
+
+309
+00:43:01,990 --> 00:43:08,950
+مية وخمس وعشرين معناته MB MB
+
+310
+00:43:13,480 --> 00:43:16,660
+على ال ... ال ... ال ... ال moment اللي هنا اللي هي
+
+311
+00:43:16,660 --> 00:43:23,460
+تسعمئة وأربعة من تشابه مثلثات بتساوي ميتين و
+
+312
+00:43:23,460 --> 00:43:30,240
+خمسين على تلات مية وخمس وعشرين منها بحسب ال Mb
+
+313
+00:43:46,950 --> 00:43:52,870
+وبتطلع ستمية وخمسة وتسعين نيوتن
+
+314
+00:43:52,870 --> 00:43:56,070
+متر ال Mb
+
+315
+00:44:06,200 --> 00:44:11,960
+ال ... طبعا أنا هنا ه ... ه ... ه ... هحمل اللي هو ال
+
+316
+00:44:11,960 --> 00:44:15,480
+transfers shear stress لأن anyway ... anyway مش
+
+317
+00:44:15,480 --> 00:44:18,240
+هحمله anyway على المحيط ال transfers shear stress
+
+318
+00:44:18,240 --> 00:44:22,560
+بيكون ساوى صفر بيكون maximum في النص ال bend ... ال
+
+319
+00:44:22,560 --> 00:44:24,360
+stress ... ال normal stress due to bending بيكون
+
+320
+00:44:24,360 --> 00:44:28,500
+maximum على المحيط وصفر في النص معناته I will
+
+321
+00:44:28,500 --> 00:44:31,980
+consider only bending في الحالة ... الحالة دي ال
+
+322
+00:44:31,980 --> 00:44:39,690
+sigma عند B ال normal stress sigma o هتكون الساوية M
+
+323
+00:44:39,690 --> 00:44:49,790
+ب في C على I هتكون الساوية M ب ال C عبارة عن D
+
+324
+00:44:49,790 --> 00:44:59,450
+على اتنين وال I باي على أربعة و D أس أربعة
+
+325
+00:44:59,450 --> 00:45:08,820
+يعني هتكون الساوية اتنين وتلاتين M ب على باي D أس
+
+326
+00:45:08,820 --> 00:45:16,600
+تلاتة يعني هتساوى اتنين وتلاتين ال M ب اللي هي
+
+327
+00:45:16,600 --> 00:45:25,440
+ستمية وخمسة وتسعين على باي ال D اللي هتساوى
+
+328
+00:45:25,440 --> 00:45:28,840
+اتنين وتلاتين M ب اللي هتساوى اتنين وتلاتين في
+
+329
+00:45:28,840 --> 00:45:37,650
+605.95 الكل تربيع عشان أحوله لميجا
+
+330
+00:45:37,650 --> 00:45:47,490
+باسكال أحضره في عشرة أس سالب ستة هتكون نحسب اتنين و
+
+331
+00:45:47,490 --> 00:45:55,490
+تلاتين في ستمية وخمسة وتسعين تقسيم ال by
+
+332
+00:46:02,920 --> 00:46:07,900
+على فكرة الآلة الحاسبة بتاعتي لسه أنا مش متعود عليها
+
+333
+00:46:07,900 --> 00:46:13,420
+خليني تقسيم تلاتة point واحد أربعة تقسيم 0.
+
+334
+00:46:13,420 --> 00:46:24,360
+تلاتة اتنين أس تلاتة يساوي أقل تقسيم مليون تقسيم
+
+335
+00:46:24,360 --> 00:46:29,040
+ألف يساوي تطلع ميتين وستة عشر
+
+336
+00:46:32,950 --> 00:46:39,130
+ميجا باسكال ميجا باسكال ميجا باسكال ميجا باسكال
+
+337
+00:46:39,130 --> 00:46:40,790
+ميجا باسكال ميجا باسكال ميجا باسكال ميجا باسكال
+
+338
+00:46:40,790 --> 00:46:40,950
+ميجا باسكال ميجا باسكال ميجا باسكال ميجا باسكال
+
+339
+00:46:40,950 --> 00:46:50,790
+ميجا باسكال ميجا
+
+340
+00:46:50,790 --> 00:47:02,210
+باسكال ميجا باسكال ميجا باسكال
+
+341
+00:47:04,000 --> 00:47:10,040
+الـ Kt هضطر
+
+342
+00:47:10,040 --> 00:47:21,300
+أستخدم ال appendix A A 15 9 هروح ل A 15 9 عشان
+
+343
+00:47:21,300 --> 00:47:26,040
+أحسب ال Kt هنشوف ال appendix A 15 9
+
+344
+00:47:43,250 --> 00:47:56,570
+اللي هي دي الحالة طيب
+
+345
+00:47:56,570 --> 00:48:01,610
+عند
+
+346
+00:48:01,610 --> 00:48:08,910
+ال R على D بلزمني أحسب ال R على D بلزمني
+
+347
+00:48:08,910 --> 00:48:16,130
+أحسب ال R على D الـ R تلاتة على اتنين وتلاتين أو
+
+348
+00:48:16,130 --> 00:48:26,730
+أحسب ال D الكبيرة على D ثمانية وتلاتين على
+
+349
+00:48:26,730 --> 00:48:31,930
+اتنين وتلاتين تلاتة
+
+350
+00:48:31,930 --> 00:48:40,670
+تقسيم اتنين وتلاتين تطلع تقريبا 1.1 وهذه
+
+351
+00:48:40,670 --> 00:48:41,490
+ثمانية وتلاتين
+
+352
+00:48:46,680 --> 00:48:54,020
+بتطلع واحد point واحد ثمانية سبعة خمسة أنا عندي هنا
+
+353
+00:48:54,020 --> 00:49:01,160
+1.1 بجا
+
+354
+00:49:01,160 --> 00:49:08,800
+بين التانية والتالت تقريبا واحد point ستة
+
+355
+00:49:08,800 --> 00:49:11,800
+واحد point ستة خمسة ال Kt
+
+356
+00:49:16,060 --> 00:49:43,280
+1.65 حسبت
+
+357
+00:49:43,280 --> 00:49:58,210
+الكتاب يطلع 1.6 خمسة بدي أحسب ال ... Kf  So واحد زائد
+
+358
+00:49:58,210 --> 00:50:05,670
+كيو في Kt ناقص واحد ال Kt قريبا حسبتها ال كيو هروح
+
+359
+00:50:05,670 --> 00:50:13,410
+على شكل ستة وعشرين هنروح في figure ستة وعشرين هنشوف
+
+360
+00:50:13,410 --> 00:50:14,510
+figure ستة وعشرين
+
+361
+00:50:20,810 --> 00:50:34,930
+عند ال SUT عند ال R تلاتة ملي التلات
+
+362
+00:50:34,930 --> 00:50:46,370
+يعني تقريبا bond two bond two على تلاتة زائد
+
+363
+00:50:46,370 --> 00:50:47,510
+bond ثمانية
+
+364
+00:50:51,320 --> 00:50:57,640
+بتطلع تقريبا bond ثمانية ستة كيو
+
+365
+00:50:57,640 --> 00:51:00,660
+بس
+
+366
+00:51:00,660 --> 00:51:06,700
+هو bond ثمانية ستة خمسة ومنها بحسب ال kf هتكون
+
+367
+00:51:06,700 --> 00:51:12,520
+واحد زائد bond ثمانية ستة خمسة في واحد bond ستة خمسة
+
+368
+00:51:12,520 --> 00:51:13,420
+ناقص واحد
+
+369
+00:51:25,900 --> 00:51:32,000
+واحد point خمسة ستة اتنين واحد point خمسة ستة
+
+370
+00:51:32,000 --> 00:51:38,000
+اتنين معناته ال maximum stress عند ال critical
+
+371
+00:51:38,000 --> 00:51:45,400
+point ال sigma هتكون Kf في ال sigma o
+
+372
+00:51:50,420 --> 00:51:56,720
+اللي هي واحد point خمسة ستة اتنين في sigma o اللي
+
+373
+00:51:56,720 --> 00:52:09,200
+هي ميتين وستة عشر تطلع
+
+374
+00:52:09,200 --> 00:52:15,620
+تلتماية وسبعة وتلاتين ميجا
+
+375
+00:52:15,620 --> 00:52:17,660
+باسكال
+
+376
+00:52:45,730 --> 00:52:52,410
+طيب لأن هحسب ال Se' بساوي
+
+377
+00:52:52,410 --> 00:53:01,970
+نص ال SUT هتساوى نص ال SUT اللي هي ستمية وتسعين
+
+378
+00:53:01,970 --> 00:53:06,670
+ميجا يعني هيكون تلات
+
+379
+00:53:09,780 --> 00:53:22,480
+تلاتماية وخمسة وأربعين ميجا باسكال طب
+
+380
+00:53:22,480 --> 00:53:29,280
+محتاج أعملها correction لل ... correction لل Se
+
+381
+00:53:29,280 --> 00:53:30,100
+prime
+
+382
+00:53:37,910 --> 00:53:52,510
+بدي أحسب ال Ka ال Ka So  SUT  بص B طبعا هذا it
+
+383
+00:53:52,510 --> 00:53:57,210
+is machined أكيد الشفت هذا مش معمول hot rolling
+
+384
+00:53:57,210 --> 00:53:58,390
+أكيد machined
+
+385
+00:54:06,470 --> 00:54:14,230
+الـ Ka مازالوا ماشيين هتكون ال
+
+386
+00:54:14,230 --> 00:54:21,530
+... ال ... ال Ka بتاعته ال A أربعة point أربعة point
+
+387
+00:54:21,530 --> 00:54:28,730
+خمسة واحد أربعة ال A هتكون أربعة point خمسة واحد
+
+388
+00:54:28,730 --> 00:54:33,870
+في ال SC2 ستمية وتسعين أقصى B دي ناقص point
+
+389
+00:54:36,820 --> 00:54:43,300
+اتنين ستة خمسة ال Ka عندي
+
+390
+00:54:43,300 --> 00:54:51,840
+ستمية وتسعين أقصى ناقص point اتنين ستة خمسة في
+
+391
+00:54:51,840 --> 00:54:57,900
+أربعة point خمسة واحد هيطلع 0.798
+
+392
+00:54:57,900 --> 00:55:01,940
+0.79
+
+393
+00:55:01,940 --> 00:55:05,320
+ثمانية هذا ال Ka هذا اللي هي ال surface finish
+
+394
+00:55:05,320 --> 00:55:18,080
+factor ال Kb ال Kb ال Kb هتكون اللي هو ال size
+
+395
+00:55:18,080 --> 00:55:23,640
+factor Kb بتساوي
+
+396
+00:55:23,640 --> 00:55:28,380
+واحد point اتنين أربعة في
+
+397
+00:55:28,380 --> 00:55:32,620
+دي أقصى ناقص point واحد صفر سبعة يعني واحد point
+
+398
+00:55:32,620 --> 00:55:40,510
+اتنين أربعة القطر عندي اتنين وتلاتين أقصى ناقص
+
+399
+00:55:40,510 --> 00:55:46,430
+point واحد صفر سبعة اتنين
+
+400
+00:55:46,430 --> 00:55:55,150
+وتلاتين أقصى ناقص 0.107 يساوي
+
+401
+00:55:55,150 --> 00:56:01,670
+في واحد point اتنين أربعة تطلع 0.58
+
+402
+00:56:01,670 --> 00:56:04,790
+خمسة
+
+403
+00:56:04,790 --> 00:56:05,530
+ستة
+
+404
+00:56:22,120 --> 00:56:30,960
+0.856 ال loading factor bending معناته Kb بتساوي
+
+405
+00:56:30,960 --> 00:56:38,230
+واحد فش ال temperature effect ومفيش هنا معلومات
+
+406
+00:56:38,230 --> 00:56:43,070
+عن ريابلت
+
+445
+01:01:53,310 --> 01:01:58,950
+8.45 في 690 ÷ 2
+
+446
+01:01:58,950 --> 01:02:08,170
+و 35 تطلع 2.48
+
+447
+01:02:08,170 --> 01:02:12,450
+واحد و الـ B
+
+448
+01:02:15,260 --> 01:02:25,340
+الـ B = minus ثلث log الـ F S U T / الـ S A
+
+449
+01:02:25,340 --> 01:02:33,820
+يعني هتكون = minus ثلث log الـ F عندي اللي
+
+450
+01:02:33,820 --> 01:02:42,000
+هي bond 845 في 690 / 2
+
+451
+01:02:42,000 --> 01:02:49,520
+و 35 هتكون تساوي log اللي هي bond 8
+
+452
+01:02:49,520 --> 01:02:54,700
+45 في 690 ÷ 2 و
+
+453
+01:02:54,700 --> 01:03:04,950
+35 = ÷ 3 هتكون minus 1.315
+
+454
+01:03:04,950 --> 01:03:24,770
+طيب
+
+455
+01:03:24,770 --> 01:03:31,170
+معناته
+
+456
+01:03:31,170 --> 01:03:31,630
+الآن
+
+457
+01:03:35,590 --> 01:03:43,330
+الآن = sigma reversible / a<sup>1</sup>/b
+
+458
+01:03:43,330 --> 01:03:48,390
+سيكون sigma reversible اللي إحنا حسبناها اللي هي
+
+459
+01:03:48,390 --> 01:03:51,790
+307.5 307.5
+
+460
+01:03:54,250 --> 01:04:00,570
+andi 2.481 ÷ 1/
+
+461
+01:04:00,570 --> 01:04:11,090
+minus 1.315 نحسبها 307
+
+462
+01:04:11,090 --> 01:04:15,670
+و 30 ÷
+
+463
+01:04:15,670 --> 01:04:22,050
+2.481 =
+
+464
+01:04:27,020 --> 01:04:35,940
+1 ÷ minus 0.1315
+
+465
+01:04:35,940 --> 01:04:41,540
+إيه الساعة؟ ما فيه
+
+466
+01:04:41,540 --> 01:04:45,660
+إيش غلط؟ على فكرة، هنا اه، الـ a هنا غلط، هذا هو
+
+467
+01:04:45,660 --> 01:04:50,040
+التربيع طبعًا، عرفت إن أنا غلط، طلع عندي الرقم شيء
+
+468
+01:04:50,040 --> 01:04:53,240
+عشر أو  رقم مش منطقي، بيعني إن فيه
+
+469
+01:04:53,240 --> 01:04:58,340
+غلط، لازم يكون عندك حس في الأرقام، من الواضح أن الـ a
+
+470
+01:04:58,340 --> 01:05:02,360
+غلط، عندي هيكون الـ a، خلّنا نحسبها 0.845
+
+471
+01:05:02,360 --> 01:05:10,820
+في 690 = تربيع = ÷ 2
+
+472
+01:05:10,820 --> 01:05:17,780
+و 35 بتطلع 1447
+
+473
+01:05:17,780 --> 01:05:21,020
+هذا
+
+474
+01:05:21,020 --> 01:05:23,380
+الـ a، عشان هيك الأشياء هتختلف
+
+475
+01:05:26,270 --> 01:05:33,770
+1447 ÷ 307
+
+476
+01:05:33,770 --> 01:05:42,590
+÷ 1.447 =  ÷
+
+477
+01:05:42,590 --> 01:05:50,690
+سالب 0.1315 = تطلع
+
+478
+01:05:50,690 --> 01:05:57,890
+حوالي 64932 cycle
+
+479
+01:05:57,890 --> 01:06:03,570
+معناته الـ part هذا هيصمد هيعيش حوالي 65
+
+480
+01:06:03,570 --> 01:06:08,550
+ألف cycle لـ الـ loading الموجود اللي هو عنده في
+
+481
+01:06:08,550 --> 01:06:17,750
+النص 6.8 كيلو نيوتن، نكتفي اليوم، بكرا بنخش على
+
+482
+01:06:17,750 --> 01:06:23,510
+موضوع جديد في الـ fatigue design بتفصيل أكتر يعني
+
+483
+01:06:23,510 --> 01:06:27,910
+هيكون شغل أكتر من الشغل اللي إحنا عملناه لحد اللحظة
diff --git a/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/E30F47W7ioI_postprocess.srt b/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/E30F47W7ioI_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..d19e25c0c1ae7198301980629d7f8ca061d51b42
--- /dev/null
+++ b/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/E30F47W7ioI_postprocess.srt
@@ -0,0 +1,1820 @@
+1
+00:00:04,980 --> 00:00:07,400
+بسم الله الرحمن الرحيم السلام عليكم و رحمة الله
+
+2
+00:00:07,400 --> 00:00:10,720
+اليوم هنبدأ chapter جديد اللي هو هيكون على
+
+3
+00:00:10,720 --> 00:00:15,120
+deflection and stiffness of mechanical elements ال
+
+4
+00:00:15,120 --> 00:00:18,120
+chapter الفاتر احنا درسنا اللي هو stress analysis
+
+5
+00:00:18,120 --> 00:00:22,480
+of mechanical elements اليوم في ال chapter هذا
+
+6
+00:00:22,480 --> 00:00:26,800
+هندرس اللي هو spring ratesالـ tension و ال
+
+7
+00:00:26,800 --> 00:00:31,220
+deflection due to tension, compression and torsion
+
+8
+00:00:31,220 --> 00:00:34,840
+و برضه ال spring rate due to tension, compression
+
+9
+00:00:34,840 --> 00:00:43,840
+and torsion حدث ال deflection due to bendingهنتعرف
+
+10
+00:00:43,840 --> 00:00:46,800
+على طرق لحسابات ال deflection منها ال
+
+11
+00:00:46,800 --> 00:00:49,600
+superposition ال straight energy ال castellano
+
+12
+00:00:49,600 --> 00:00:53,940
+theorem بعدها هنتعرف على deflection of curved
+
+13
+00:00:53,940 --> 00:00:59,120
+members بعدها هنتعرف كيف نحل المسائل بتكون غير
+
+14
+00:00:59,120 --> 00:01:02,180
+قابلة لحل بالطرق التقليدية اللي هي statically
+
+15
+00:01:02,180 --> 00:01:06,180
+indeterminate problems بعدها هندرس ظاهرة ال
+
+16
+00:01:06,180 --> 00:01:09,220
+buckling او ال compression of mechanical members
+
+17
+00:01:09,960 --> 00:01:15,700
+اللي هي ظاهرة الانبعاج في الأعمدة نتيجة أنه متعرض
+
+18
+00:01:15,700 --> 00:01:20,160
+لقوة انضغاط طبعا قوة الانضغاط ممكن تكون مركزية
+
+19
+00:01:20,160 --> 00:01:24,700
+يعني بتمر في محور المنبر أو غير مركزية بتمرش في
+
+20
+00:01:24,700 --> 00:01:25,240
+المحور
+
+21
+00:01:28,120 --> 00:01:33,800
+هنبدأ بالبعض المفاهيم البسيطة كتقديم لهذا ال
+
+22
+00:01:33,800 --> 00:01:38,960
+chapter هنعرف ال elasticity و هنعرف ال spring ال
+
+23
+00:01:38,960 --> 00:01:44,340
+elasticity او اليونة للمادة هي خاصية للمادة
+
+24
+00:01:44,340 --> 00:01:49,760
+بتمكنها من استرجاع شكلها الأصليطبعا اي mechanical
+
+25
+00:01:49,760 --> 00:01:55,520
+element اتعرض لقوة بيصير فيه deformation if this
+
+26
+00:01:55,520 --> 00:01:59,600
+mechanical element is elastic then it will regain
+
+27
+00:01:59,600 --> 00:02:03,460
+its original shape before deformation upon
+
+28
+00:02:03,460 --> 00:02:07,220
+removing the load يعني هذه هي ظاهرة ال elasticity
+
+29
+00:02:07,220 --> 00:02:13,700
+ظاهرة او خاصية للمادة بتمكنها من استرجاع شكلها اذا
+
+30
+00:02:13,700 --> 00:02:19,980
+رفعت الحمل عنها فين دي ال springال spring أو
+
+31
+00:02:19,980 --> 00:02:23,720
+الزنبارك ال spring is a mechanical element that
+
+32
+00:02:23,720 --> 00:02:26,900
+exerts a force when deformed يعني إذا عند زنبارك
+
+33
+00:02:26,900 --> 00:02:32,060
+ضغطه أكيد هستيلي عليه قوة ضغط من زنبارك على إيدي
+
+34
+00:02:32,060 --> 00:02:37,020
+إذا سحبته هحاول يرجّهني لوضع الأصل معناته due to
+
+35
+00:02:37,020 --> 00:02:44,680
+deforming the spring it exerts a force ال
+
+36
+00:02:44,680 --> 00:02:51,290
+spring ريت من ال physics معرف ال Kas a function of
+
+37
+00:02:51,290 --> 00:03:00,310
+y بساوية dF by dy المعنى انت ال spring rate او ال
+
+38
+00:03:00,310 --> 00:03:07,450
+spring constant يعني بيعبر عن how much force I
+
+39
+00:03:07,450 --> 00:03:16,850
+need to deflect Delta Y اذا عند زنبراك اثرت
+
+40
+00:03:16,850 --> 00:03:18,370
+عليه force F
+
+41
+00:03:23,190 --> 00:03:27,610
+هيصير فيه ايش؟
+
+42
+00:03:27,610 --> 00:03:31,890
+Deflection قيمته
+
+43
+00:03:31,890 --> 00:03:39,630
+Delta Y معناته
+
+44
+00:03:39,630 --> 00:03:46,030
+if I increase ال force then I have to decrease the
+
+45
+00:03:46,030 --> 00:03:50,070
+deflection او اذا زودت ال deflection لازم ازود ال
+
+46
+00:03:50,070 --> 00:03:55,940
+forceإذا كان دي ال spring linear يعني ال spring
+
+47
+00:03:55,940 --> 00:04:04,760
+force هاي ال Y و هاي ال F تتغير بشكل خط مع ال
+
+48
+00:04:04,760 --> 00:04:12,460
+deflection بيكون ال K بيستوي
+
+49
+00:04:12,460 --> 00:04:18,400
+F على Y هذا for linear spring
+
+50
+00:04:27,570 --> 00:04:32,550
+طبعا كل mechanical element له spring constant حتى
+
+51
+00:04:32,550 --> 00:04:37,910
+له مش دمبرك ال spring constant حسابه بيعتمد على
+
+52
+00:04:37,910 --> 00:04:44,110
+طبيعة ال loading اول حالة هناخدها اذا كان عندي
+
+53
+00:04:44,110 --> 00:04:50,930
+mechanical element under axial
+
+54
+00:04:50,930 --> 00:04:51,450
+loading
+
+55
+00:04:56,040 --> 00:05:14,720
+و هذا originally في البداية كان طوله L المقطع
+
+56
+00:05:14,720 --> 00:05:25,080
+التبعه cross sectional area
+
+57
+00:05:26,880 --> 00:05:34,140
+بتساوي A نتيجة ال force F هيصير عنده stress ال
+
+58
+00:05:34,140 --> 00:05:42,060
+stress هيكون بساوية sigma بساوية F على A ال
+
+59
+00:05:42,060 --> 00:05:46,020
+F اللي هي ال axial force وال A مساحة المقطع وإذا
+
+60
+00:05:46,020 --> 00:05:52,320
+كنت في ال elastic region هيكون بساوية E في أبسلون
+
+61
+00:05:52,320 --> 00:05:54,180
+E هي ال modulus
+
+62
+00:05:58,780 --> 00:06:10,280
+of elasticity معامل المرونة و epsilon ال strain و
+
+63
+00:06:10,280 --> 00:06:16,740
+had this relation valid
+
+64
+00:06:16,740 --> 00:06:20,900
+only
+
+65
+00:06:20,900 --> 00:06:25,720
+in the elastic range
+
+66
+00:06:30,760 --> 00:06:44,980
+الـ Strain بيساوي اللي هو Delta L على L يعني
+
+67
+00:06:44,980 --> 00:06:52,900
+هنا هسير عندى Sigma بيساوي F على A بيساوي E في
+
+68
+00:06:52,900 --> 00:06:55,420
+Delta L على
+
+69
+00:06:57,200 --> 00:07:05,800
+L خلينا نسميها Delta L يعني احنا سيراندي F على A
+
+70
+00:07:05,800 --> 00:07:15,540
+بسوء E في Delta على L يعني
+
+71
+00:07:15,540 --> 00:07:22,840
+احنا سيراندي F بسوء A E على L
+
+72
+00:07:25,650 --> 00:07:30,310
+في delta احنا نشوف ال .. ال .. ال .. ال .. ال ..
+
+73
+00:07:30,310 --> 00:07:32,050
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+74
+00:07:32,050 --> 00:07:33,430
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+75
+00:07:33,430 --> 00:07:33,530
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+76
+00:07:33,530 --> 00:07:34,650
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+77
+00:07:34,650 --> 00:07:36,210
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+78
+00:07:36,210 --> 00:07:40,750
+.. ال .. ال .. ال .. ال ..
+
+79
+00:07:40,750 --> 00:07:42,050
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+80
+00:07:42,050 --> 00:07:42,110
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+81
+00:07:42,110 --> 00:07:42,610
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+82
+00:07:42,610 --> 00:07:47,090
+ال .. ال .. ال ..
+
+83
+00:07:47,090 --> 00:07:51,230
+ال .. ال ..
+
+84
+00:07:55,790 --> 00:08:01,870
+و هذا deflection
+
+85
+00:08:01,870 --> 00:08:09,070
+معناته هذا ال term هذا
+
+86
+00:08:09,070 --> 00:08:12,930
+force و
+
+87
+00:08:12,930 --> 00:08:19,250
+هذا deflection معناته
+
+88
+00:08:19,250 --> 00:08:25,230
+هذا ايش هيكون؟ K معناته فيmechanical element under
+
+89
+00:08:25,230 --> 00:08:29,370
+axial loading سواء كان tension or compression
+
+90
+00:08:29,370 --> 00:08:41,850
+هيكون F بالساوية K في Delta where K بالساوية A في
+
+91
+00:08:41,850 --> 00:08:47,190
+E على L المعنى هو إذا عندي mechanical element
+
+92
+00:08:47,190 --> 00:08:54,740
+under axial loading ممكن اعتبره زنبركالزمبارك ال
+
+93
+00:08:54,740 --> 00:08:58,600
+spring rate هو given by a في e على l ال a اللي هي
+
+94
+00:08:58,600 --> 00:09:03,760
+مساحة المقطع ال e اللي هي modulus of elasticity و
+
+95
+00:09:03,760 --> 00:09:14,220
+ال l اللي هي طول ال mechanical element بالنسبة
+
+96
+00:09:14,220 --> 00:09:18,160
+لل torsion اللي هي loaded member
+
+97
+00:09:29,160 --> 00:09:34,460
+for a torrentially loaded member فهيكون عنده لو
+
+98
+00:09:34,460 --> 00:09:53,420
+افترضت انه مقطع مدور و
+
+99
+00:09:53,420 --> 00:10:08,820
+under بيأثر عليه torqueT حسين
+
+100
+00:10:08,820 --> 00:10:17,780
+دي اللي هي angular deflection ثتا
+
+101
+00:10:19,970 --> 00:10:24,470
+احنا من شبطر تلاتة حسبنا theta هذا فحسب theta
+
+102
+00:10:24,470 --> 00:10:37,690
+بتساوي T في L على G في J يعني الـ T بتساوي G في G
+
+103
+00:10:37,690 --> 00:10:47,170
+على L في Theta الـ G اللي هي ال modulus G modulus
+
+104
+00:10:50,610 --> 00:10:56,770
+of rigidity أو
+
+105
+00:10:56,770 --> 00:11:05,010
+ممكن نسمي الـ shear modulus shear modulus و
+
+106
+00:11:05,010 --> 00:11:14,210
+ال J ال polar moment of
+
+107
+00:11:14,210 --> 00:11:14,750
+inertia
+
+108
+00:11:18,170 --> 00:11:26,050
+of the cross section و
+
+109
+00:11:26,050 --> 00:11:32,990
+ال L ال
+
+110
+00:11:32,990 --> 00:11:38,690
+L ال length و
+
+111
+00:11:38,690 --> 00:11:45,770
+ال theta ال angular deflection
+
+112
+00:12:03,080 --> 00:12:10,980
+هأخدها تحت هنا ال torque بالساوية جي في جي على ال
+
+113
+00:12:10,980 --> 00:12:18,080
+في ثيتا و اتداخل حالة ال axis loading member
+
+114
+00:12:18,080 --> 00:12:22,180
+cannon دي ال F بالساوية
+
+115
+00:12:22,180 --> 00:12:32,080
+A في E على L في دلتا في حالة الحركة الخطية بيكون
+
+116
+00:12:32,080 --> 00:12:38,370
+دي forceفي حالة عندي rotation twist بيكون دي
+
+117
+00:12:38,370 --> 00:12:44,830
+torgen او torque في
+
+118
+00:12:44,830 --> 00:12:50,490
+حالة الحركة الخطية بيصير عندي ايش؟ deflection في
+
+119
+00:12:50,490 --> 00:12:55,750
+حالة ال rotation بيصير عندي ايش؟ angle مع أن
+
+120
+00:12:55,750 --> 00:12:59,290
+الناتوا هدول المعادلتين ماخدين نفس الشكل معناته ال
+
+121
+00:12:59,290 --> 00:13:03,290
+torque بالساوية
+
+122
+00:13:04,420 --> 00:13:12,540
+K في theta K هي ال stiffness او ال K هي ال spring
+
+123
+00:13:12,540 --> 00:13:15,260
+rate لتورجن ال loaded member
+
+124
+00:13:17,880 --> 00:13:23,080
+اللي هي هتكون تستوى G في J على L المعنى بتقول ال
+
+125
+00:13:23,080 --> 00:13:26,860
+spring constant او ال spring rate for a
+
+126
+00:13:26,860 --> 00:13:30,380
+torsionally loaded member is given by this
+
+127
+00:13:30,380 --> 00:13:35,440
+relation اللي هو G J على L يعني كل ما زادت ال
+
+128
+00:13:35,440 --> 00:13:39,760
+shear modulus او modulus of .. ال modulus of
+
+129
+00:13:39,760 --> 00:13:44,140
+rigidity كل ما زادت ال K كل ما كان المقطع أكبر
+
+130
+00:13:44,140 --> 00:13:50,210
+يعني .. يعني صعب انه اعملهrotation برضه ال K
+
+131
+00:13:50,210 --> 00:13:54,430
+بالزيد كل ما كان الاشي طويل اكتر اسهل ان اعمله ايش
+
+132
+00:13:54,430 --> 00:14:03,910
+اعمله deflection طيب
+
+133
+00:14:03,910 --> 00:14:15,550
+هندرس الآن ال deflection due
+
+134
+00:14:15,550 --> 00:14:16,490
+to bending load
+
+135
+00:14:22,830 --> 00:14:37,950
+يعني لو كان عندى beam وعليه
+
+136
+00:14:37,950 --> 00:14:45,990
+مثلا force في المصر هيكون
+
+137
+00:14:45,990 --> 00:14:53,750
+ليه two reactions يعني reaction هنا f على 2 وهناف
+
+138
+00:14:53,750 --> 00:15:00,270
+على اتنين لو ارسم ال shear diagram ال
+
+139
+00:15:00,270 --> 00:15:12,550
+shear diagram هيكون بالشكل هذا هذه
+
+140
+00:15:12,550 --> 00:15:20,050
+f على اتنين هذه minus f على اتنين و ال moment
+
+141
+00:15:20,050 --> 00:15:20,550
+diagram
+
+142
+00:15:30,400 --> 00:15:38,340
+طبعا اذا كان هذا طوله L هذا
+
+143
+00:15:38,340 --> 00:15:46,200
+هتكون طوله L على 2 هذا
+
+144
+00:15:46,200 --> 00:15:50,880
+هتكون F L على
+
+145
+00:15:50,880 --> 00:15:56,720
+4 هذا ال moment دياجرام
+
+146
+00:16:00,000 --> 00:16:04,300
+و هذا ال shear diagram
+
+147
+00:16:04,300 --> 00:16:07,660
+احنا
+
+148
+00:16:07,660 --> 00:16:12,560
+في شبطر تلاتة فكنا
+
+149
+00:16:12,560 --> 00:16:18,500
+طبعا هذا هسيرله ايش؟ هسيره deflection هسير بالشكل
+
+150
+00:16:18,500 --> 00:16:24,540
+هذا النقطة معينة هي radius of curvature هذا رو
+
+151
+00:16:24,540 --> 00:16:41,480
+فاندي واحد على روبالساوية M على E في I رو
+
+152
+00:16:41,480 --> 00:16:47,800
+هو ال radius of
+
+153
+00:16:47,800 --> 00:16:53,120
+curvature at
+
+154
+00:16:53,120 --> 00:16:57,880
+a given point
+
+155
+00:17:00,040 --> 00:17:07,480
+on the beam و
+
+156
+00:17:07,480 --> 00:17:18,000
+M هي ال moment ال course of ending moment
+
+157
+00:17:18,000 --> 00:17:21,220
+at
+
+158
+00:17:21,220 --> 00:17:27,980
+the given section
+
+159
+00:17:32,750 --> 00:17:45,030
+و ال E اللي هو معامل مرونا Modulus of elasticity و
+
+160
+00:17:45,030 --> 00:17:49,630
+ال I ال
+
+161
+00:17:49,630 --> 00:17:58,230
+momentum inertia of
+
+162
+00:17:58,230 --> 00:17:58,930
+the section
+
+163
+00:18:07,360 --> 00:18:12,720
+الان from calculus احنا بنعرف في علاقة الان ال
+
+164
+00:18:12,720 --> 00:18:16,060
+radius of curvature او ال .. او ال واحدة ل روه
+
+165
+00:18:16,060 --> 00:18:22,060
+بيعطيه علاقة مشتقتين d square y by dx square على
+
+166
+00:18:22,060 --> 00:18:31,800
+واحد زي ال dy على dx الكل تربيع از تلاتة على اتنين
+
+167
+00:18:31,800 --> 00:18:36,000
+يعني هنا بدك تعرف تفاصيل اكتر
+
+168
+00:18:38,670 --> 00:18:48,950
+back to calculus يعني
+
+169
+00:18:48,950 --> 00:18:55,010
+إذا كان هذا هو ال X و
+
+170
+00:18:55,010 --> 00:19:06,330
+هذا هو ال Y معناته عند نقطة هذه هذا ال slope dy by
+
+171
+00:19:06,330 --> 00:19:17,640
+dxإذا كان الـ deflection صغير كتير for small
+
+172
+00:19:17,640 --> 00:19:21,840
+slopes
+
+173
+00:19:21,840 --> 00:19:34,280
+of the deflected beam بيكون
+
+174
+00:19:34,280 --> 00:19:37,620
+عندي dy by dx
+
+175
+00:19:43,030 --> 00:19:47,250
+small معناته اذا كان ال dy by dx مثلا point one
+
+176
+00:19:47,250 --> 00:19:50,790
+معناه ال dy by dx لكل تربيع هتكون point one تربيع
+
+177
+00:19:50,790 --> 00:19:58,030
+يعني هتكون very small معناه ال dy by dx لكل تربيع
+
+178
+00:19:58,030 --> 00:20:05,670
+هتكون very small معناه
+
+179
+00:20:05,670 --> 00:20:12,580
+ال term هذاإذا dy by dx بيكون صغير يعني الكلتر
+
+180
+00:20:12,580 --> 00:20:19,500
+بيكون صغير جدا في الحالة هذه الكلتر
+
+181
+00:20:19,500 --> 00:20:26,420
+بيها is very small compared
+
+182
+00:20:26,420 --> 00:20:30,680
+بالمقارنة مع الواحد في
+
+183
+00:20:30,680 --> 00:20:33,780
+الحالة
+
+184
+00:20:33,780 --> 00:20:51,780
+دوسريندي واحد على رويصير ساعة تقريبا D2 D2
+
+185
+00:20:51,780 --> 00:21:04,860
+Y by DX2 بالساعة من هنا M على E في I معناته هذا
+
+186
+00:21:04,860 --> 00:21:11,250
+أهم relationم علي اي بساو دي square y by دي اكس
+
+187
+00:21:11,250 --> 00:21:12,210
+square
+
+188
+00:21:38,530 --> 00:21:43,210
+أحنا من ال chapter تلاتة كنا نعرف ان ال V بيساوي
+
+189
+00:21:43,210 --> 00:21:57,370
+DM by DX يعني هتساوي و DM by DX و ال Q و
+
+190
+00:21:57,370 --> 00:21:58,430
+ال V بيساوي
+
+191
+00:22:04,050 --> 00:22:11,630
+و ال Q بيستوى DV by DX معناته based on this هيكون
+
+192
+00:22:11,630 --> 00:22:17,030
+ان ال V على EI بيستوى المشتقة التالتة ل Y بالنسبة
+
+193
+00:22:17,030 --> 00:22:22,170
+ل X و ال Q على EI بيستوى المشتقة الرابعة ل Y على
+
+194
+00:22:22,170 --> 00:22:28,850
+DX احنا بشكل أساسي بتجهيبنا العلاقة اللي هي M على
+
+195
+00:22:28,850 --> 00:22:48,450
+EIبساوي المشتقة التانية d²y by dx² هنحل
+
+196
+00:22:48,450 --> 00:22:52,170
+مثال نشوف كيف ممكن نحسب ال deflection و ال slopes
+
+197
+00:22:52,170 --> 00:22:58,690
+في straight beams باستخدام علاقة م على ei بساوي
+
+198
+00:22:58,690 --> 00:23:00,210
+d²y by dx
+
+199
+00:23:07,870 --> 00:23:12,610
+خلّيني أضعها جانب M
+
+200
+00:23:12,610 --> 00:23:30,050
+عند
+
+201
+00:23:30,050 --> 00:23:34,570
+مبين beam عليه
+
+202
+00:23:34,570 --> 00:23:43,750
+load موزع Wال W قيمتها تمانين pound force لكل انش
+
+203
+00:23:43,750 --> 00:23:50,450
+ال beam طوله عشرين انش ال beam is simply supported
+
+204
+00:23:50,450 --> 00:23:51,210
+at the end
+
+205
+00:24:04,310 --> 00:24:09,370
+using equation 412 م على اي او اي بيستوى دي square
+
+206
+00:24:09,370 --> 00:24:13,910
+واي بقى دي اكس square determine equations for
+
+207
+00:24:13,910 --> 00:24:18,590
+slope and deflection of the beam بدوا معادلات ال
+
+208
+00:24:18,590 --> 00:24:24,050
+slope و ال deflection لبيم عند اي نقطة و ال slope
+
+209
+00:24:24,050 --> 00:24:29,970
+at the ends ال slope عند الأطراف و ال maximum
+
+210
+00:24:29,970 --> 00:24:32,290
+deflection ال maximum deflection طبعا في الحالة
+
+211
+00:24:32,290 --> 00:24:33,370
+هتكون في النص
+
+212
+00:24:37,940 --> 00:24:42,180
+أولش طبعا هرسم free body diagram عشان اوش دي
+
+213
+00:24:42,180 --> 00:24:46,740
+reactions are واحد وال
+
+214
+00:24:46,740 --> 00:24:54,020
+reaction are اتنين هذا
+
+215
+00:24:54,020 --> 00:24:59,500
+ال load هيكون equivalent له load
+
+216
+00:24:59,500 --> 00:25:08,160
+اللي هيكون عشرين في تمانين يعني الف و ستمائتPound
+
+217
+00:25:08,160 --> 00:25:10,800
+و ال equivalent load جاي فى النص المعناه اللى
+
+218
+00:25:10,800 --> 00:25:15,180
+هتتوزع بالتساوى على الأطراف هكون الف ستمية على
+
+219
+00:25:15,180 --> 00:25:22,460
+ايه؟ على اتنين يعني هكون عندى هنا تمانمية تمانمية
+
+220
+00:25:22,460 --> 00:25:29,480
+pound وهنا R اتنين بالساوية تمانمية pound طبعا
+
+221
+00:25:29,480 --> 00:25:33,600
+هرسم ال .. ال .. ال shear diagram و ال money
+
+222
+00:25:33,600 --> 00:25:36,140
+diagram او بدي اخد هذا ال X
+
+223
+00:25:39,030 --> 00:25:49,390
+و هذا ال Y بتاخد على مسافة X بتاخد
+
+224
+00:25:49,390 --> 00:25:55,530
+جزء من ال beam على مسافة X فين
+
+225
+00:25:55,530 --> 00:26:04,470
+دي هنا كانت force اللي هي 800 pound هذه
+
+226
+00:26:04,470 --> 00:26:05,450
+المسافة X
+
+227
+00:26:11,380 --> 00:26:19,960
+طبعا هكون في عندي shear force V و في عندي bending
+
+228
+00:26:19,960 --> 00:26:28,820
+moment M و
+
+229
+00:26:28,820 --> 00:26:35,020
+هاي ال Y direction و هاي ال X direction
+
+230
+00:26:42,800 --> 00:26:49,640
+طبعا في عندى كمان distributed load
+
+231
+00:26:49,640 --> 00:26:58,260
+لو
+
+232
+00:26:58,260 --> 00:27:03,920
+أخد summation of forces باتجاه ال Y بالساوة سفر
+
+233
+00:27:03,920 --> 00:27:07,180
+هيكون عندى
+
+234
+00:27:12,760 --> 00:27:23,940
+الأعلى عندي 800 ناقص عندي هذه 80 ناقص 80 في X لتحت
+
+235
+00:27:23,940 --> 00:27:31,920
+ناقص 80 في X لتحت minus
+
+236
+00:27:31,920 --> 00:27:38,600
+V بساوي 0 معناته
+
+237
+00:27:38,600 --> 00:27:38,980
+ال V
+
+238
+00:27:45,160 --> 00:27:56,740
+حتساوي تمانين اكس نقص تمانمية او V بستاوي العكس ال
+
+239
+00:27:56,740 --> 00:28:02,240
+V بستاوي التمانمية minus
+
+240
+00:28:02,240 --> 00:28:08,080
+تمانين اكس هذا ال V
+
+241
+00:28:13,100 --> 00:28:23,280
+احنا سابقا حكينا ال V بيساوي DM by DX ال V بيساوي
+
+242
+00:28:23,280 --> 00:28:39,400
+DM by DX معناه DM بيساوي V DX يعني هيساوي ال V
+
+243
+00:28:39,400 --> 00:28:42,620
+اللي هي 800 minus 80 X
+
+244
+00:28:45,620 --> 00:28:51,620
+DX و هنا DM هنا هعمل تكامل ال M عند الطرف كانت سفر
+
+245
+00:28:51,620 --> 00:28:59,880
+to M و هنا عندي التكامل
+
+246
+00:28:59,880 --> 00:29:07,480
+من سفر ل X يعني انا هتكون عند ال M بتساوي
+
+247
+00:29:07,480 --> 00:29:12,000
+تبنيات
+
+248
+00:29:12,000 --> 00:29:13,340
+X
+
+249
+00:29:15,610 --> 00:29:28,190
+ناقص اربعين اكس تربيع هداش ال moment لحظة
+
+250
+00:29:28,190 --> 00:29:33,290
+هو ماعطينا العلاقة هان M بالساوية W ال على اتنين
+
+251
+00:29:33,290 --> 00:29:40,090
+في اكس W تمانين تمانين و ال اكم عشرين تمانين في
+
+252
+00:29:40,090 --> 00:29:43,570
+عشرين الف ست مية على اتنين تمان مية هاي هطلع تانية
+
+253
+00:29:43,570 --> 00:29:47,760
+تمان ميةعندها و على اتنين و تمانين تمانين على
+
+254
+00:29:47,760 --> 00:29:58,780
+اتنين اربعين المناورة للعلاقات and if صحيحة لان
+
+255
+00:29:58,780 --> 00:30:05,120
+عشان اواجه ال deflection انا
+
+256
+00:30:05,120 --> 00:30:14,040
+في عند relation في علاقة بين ال M على EI بتساوي
+
+257
+00:30:16,640 --> 00:30:25,580
+الـ d² y على dx تربيع يعني
+
+258
+00:30:25,580 --> 00:30:40,920
+احاسس ان الـ d by dx ل dy by dx بتساوي عوض 1 على e
+
+259
+00:30:40,920 --> 00:30:41,540
+في i
+
+260
+00:30:45,950 --> 00:30:52,530
+الـ M اللي هي تمنمية تمنمية
+
+261
+00:30:52,530 --> 00:31:08,310
+X مينوس أربعين X تربيع بعمل
+
+262
+00:31:08,310 --> 00:31:12,970
+تكامل لهذه حسيب عندي D
+
+263
+00:31:16,280 --> 00:31:29,760
+الى dy by dx بتساوي 1 على ei في 800x minus 40x
+
+264
+00:31:29,760 --> 00:31:36,540
+تربيع dx وبعمل تكامل للطرفين
+
+265
+00:31:45,370 --> 00:32:02,030
+حسينا الـ dy by dx بتساوي 1 على ei في مشتقة 800x
+
+266
+00:32:02,030 --> 00:32:10,370
+عبارة عن 400x تربيع ناقص
+
+267
+00:32:10,370 --> 00:32:13,990
+40 ع
+
+268
+00:32:13,990 --> 00:32:20,730
+3x تكييب زائد constant واحد constant of
+
+269
+00:32:20,730 --> 00:32:24,710
+integration بعمل
+
+270
+00:32:24,710 --> 00:32:33,150
+integration كمان مرة integrate هصير
+
+271
+00:32:33,150 --> 00:32:40,630
+عندي ال y بالساوية واحد على ei
+
+272
+00:32:43,270 --> 00:33:00,690
+في 400 على 3 x تكيب ناقص 400 على 3 في 4 على 12 x
+
+273
+00:33:00,690 --> 00:33:07,650
+أص 4 زائد c1 في x زائد c2
+
+274
+00:33:11,860 --> 00:33:17,960
+لأن I have to find ال C1 and C2 using the boundary
+
+275
+00:33:17,960 --> 00:33:23,420
+or end conditions find C1
+
+276
+00:33:23,420 --> 00:33:33,240
+and C2 using the boundary conditions
+
+277
+00:33:33,240 --> 00:33:36,940
+عند
+
+278
+00:33:36,940 --> 00:33:40,420
+أنا بعرف deflection يعني عندي why
+
+279
+00:33:42,160 --> 00:33:50,620
+بتساوي Zero at X بتساوي Zero يعني لو حطيت هنا Zero
+
+280
+00:33:50,620 --> 00:33:59,580
+هكون واحد على EI طبعا في Zero ناقص Zero زائد C
+
+281
+00:33:59,580 --> 00:34:05,480
+واحد في Zero زائد C اتنين معناته C اتنين تطلع
+
+282
+00:34:05,480 --> 00:34:10,480
+تساوي ايش صفر و برضه عند ال End التاني مافيش
+
+283
+00:34:10,480 --> 00:34:19,070
+Deflectiony equals zero at
+
+284
+00:34:19,070 --> 00:34:25,870
+x بالساوية عشرين المعنى انت حاسيه ان اعوض هنا
+
+285
+00:34:25,870 --> 00:34:34,170
+حاسيه ان عندي ال zero بتساوي واحد على ei في
+
+286
+00:34:34,170 --> 00:34:47,760
+اربعمية ع تلاتة في عشرين تكييب-400 على 12 في 20
+
+287
+00:34:47,760 --> 00:34:52,340
+أقصى 4 زائد
+
+288
+00:34:52,340 --> 00:35:02,240
+C1 في 20 يعني
+
+289
+00:35:02,240 --> 00:35:05,080
+إذا قسمت الطرفين على 20 هسينا اندي C1
+
+290
+00:35:07,550 --> 00:35:20,170
+هتكون تساوي واحد على EI فيه
+
+291
+00:35:20,170 --> 00:35:31,010
+اربعمية ع اتناش يعني مية ع تلاتة فعشرين تكييب ناقص
+
+292
+00:35:31,010 --> 00:35:35,270
+اربعمية
+
+293
+00:35:37,300 --> 00:35:41,540
+ع تلاتة في
+
+294
+00:35:41,540 --> 00:35:45,740
+عشرين تربيع
+
+295
+00:35:45,740 --> 00:35:49,340
+يعني
+
+296
+00:35:49,340 --> 00:35:57,620
+إذا خدتها على مشترك عشرين تربيع في مية يعني أخدت
+
+297
+00:35:57,620 --> 00:36:06,620
+تلاتة برا و أخدت عشرين تربيع اللي هي أربعة مية مية
+
+298
+00:36:08,470 --> 00:36:14,390
+في عشرين تربيع بتصفى
+
+299
+00:36:14,390 --> 00:36:17,730
+مية
+
+300
+00:36:17,730 --> 00:36:24,850
+ع تلاتة بتروح وعشرين تربيع بتصفى عندهين عشرين ناقص
+
+301
+00:36:24,850 --> 00:36:29,290
+حد
+
+302
+00:36:29,290 --> 00:36:31,270
+على مية ناقص أربعة
+
+303
+00:36:37,490 --> 00:36:46,350
+يعني انا هتكون اربعة
+
+304
+00:36:46,350 --> 00:36:54,130
+عندين اتنين اتنين اربعة واحد اتنين تلاتة اربعة
+
+305
+00:36:54,130 --> 00:37:02,250
+أسفار في ستاش ع تلاتة في EI
+
+306
+00:37:08,440 --> 00:37:11,200
+معناته هتصير المعادل بتاع الـ deflection الـ Y
+
+307
+00:37:11,200 --> 00:37:14,840
+هتساوي
+
+308
+00:37:14,840 --> 00:37:18,760
+1
+
+309
+00:37:18,760 --> 00:37:34,200
+على EI في 400 ع 3 X سكيب ناقص 400 ع 12 X أس 4
+
+310
+00:37:36,620 --> 00:37:43,620
+أربعمية اربعمية اربعين أربعين الف في ستاش ع تلاتة
+
+311
+00:37:43,620 --> 00:37:49,180
+EI في X هذه
+
+312
+00:37:49,180 --> 00:37:57,860
+معادلة ال deflection ال slope هيكون DY by DX
+
+313
+00:38:06,040 --> 00:38:13,840
+هيكون واحد على EI فيه
+
+314
+00:38:13,840 --> 00:38:26,440
+أربعمية X تربية ناقص أربعمية على تلاتة هذه X تربية
+
+315
+00:38:26,440 --> 00:38:33,380
+هذه X تكيب زائد
+
+316
+00:38:33,380 --> 00:38:46,040
+أربعميةفى 16 ع 3EI طبعا
+
+317
+00:38:46,040 --> 00:38:51,460
+المعادلة هذه بتعطى deflection anywhere and at any
+
+318
+00:38:51,460 --> 00:38:57,600
+x و المعادلة التانية بتعطى slope
+
+319
+00:39:06,320 --> 00:39:13,180
+الـ male at any x الان
+
+320
+00:39:13,180 --> 00:39:16,820
+بد هو الـ deflection at the ends يعني بد الـ
+
+321
+00:39:16,820 --> 00:39:22,100
+deflection at x equal zero و الـ deflection at x
+
+322
+00:39:22,100 --> 00:39:24,840
+يساوي L اللي هي عشرين at
+
+323
+00:39:33,790 --> 00:39:44,010
+x equals 0 هيكون y dy ال slope dy
+
+324
+00:39:44,010 --> 00:39:50,530
+by dx هتساوي .. هنعوض هنا عن x الساوية zero سفر
+
+325
+00:39:50,530 --> 00:40:00,030
+سفر هتكون أربعمية في ستاش على E في I طبعا E بنعوض
+
+326
+00:40:00,030 --> 00:40:07,790
+عنا I بنعوض على هذهعند X بالساوية سفر و DY by DX
+
+327
+00:40:07,790 --> 00:40:17,630
+عند X بالساوية عشرين هتساوية عموضين واحد
+
+328
+00:40:17,630 --> 00:40:30,520
+على EI في أربعمية في عشرين تربيع ناقص أربعميةفي
+
+329
+00:40:30,520 --> 00:40:42,100
+عشرين تكييب على تلاتة زائد أربعمية في ستاش على
+
+330
+00:40:42,100 --> 00:40:51,440
+تلاتة EI و بنحسبها ال maximum deflection one هيكون
+
+331
+00:40:51,440 --> 00:40:59,720
+في النص هذا ال maximum deflection
+
+332
+00:41:03,310 --> 00:41:11,690
+deflection is maximum
+
+333
+00:41:11,690 --> 00:41:19,650
+at x بالساوية L على 2 اللي هي بالساوية عشرة يعني
+
+334
+00:41:19,650 --> 00:41:25,030
+هتكون y maximum بتساوي
+
+335
+00:41:25,030 --> 00:41:28,430
+واحد
+
+336
+00:41:28,430 --> 00:41:41,040
+على EIفي اربعمية على تلاتة في عشرة تكييب ناقص
+
+337
+00:41:41,040 --> 00:41:50,660
+اربعمية على اتناش في عشرة اقص اربعة زائد
+
+338
+00:42:01,440 --> 00:42:06,140
+هذه في صفرين على فكرة هنا زائد
+
+339
+00:42:06,140 --> 00:42:09,340
+اربعين
+
+340
+00:42:09,340 --> 00:42:19,140
+الف في ستاشع ع تلاتة EI في عشرة و بنحسب القيامة
+
+341
+00:42:19,140 --> 00:42:25,360
+بتوقع انكوا تحسبوا الأرقام و تطلعوا أرقام حقيقية
+
+342
+00:42:49,680 --> 00:42:51,080
+مش عارف كده
+
+343
+00:43:06,670 --> 00:43:10,310
+الان في اكتر من طريقة لحساب الـ deflections في ال
+
+344
+00:43:10,310 --> 00:43:13,810
+.. في ال beams فى عندنا superposition method فى
+
+345
+00:43:13,810 --> 00:43:16,510
+عند ال moment area method عند numerical
+
+346
+00:43:16,510 --> 00:43:20,210
+integration عندنا Castellano method وعندنا ال
+
+347
+00:43:20,210 --> 00:43:26,330
+finite element method هنبدأ في ال .. ال beam
+
+348
+00:43:26,330 --> 00:43:30,230
+deflection by superposition ال beam deflection by
+
+349
+00:43:30,230 --> 00:43:33,970
+superposition تعتمد إذا أنا كان beam عليه loading
+
+350
+00:43:35,070 --> 00:43:39,690
+معين متنوع ممكن اجزء ال effect يعني ال total
+
+351
+00:43:39,690 --> 00:43:44,250
+effect عبارة عن مجموع individual effects و بستخدم
+
+352
+00:43:44,250 --> 00:43:47,870
+اللي هي ال beef deflection formulas من ال appendix
+
+353
+00:43:47,870 --> 00:43:55,030
+A9 اذا بنفتح الكتاب على ال appendix
+
+354
+00:43:55,030 --> 00:44:00,570
+A9
+
+355
+00:44:04,060 --> 00:44:11,480
+نفتح ال appendix هنشوف
+
+356
+00:44:11,480 --> 00:44:19,100
+في عندى beams مختلفة مثلا عندى هين كانت river beam
+
+357
+00:44:19,100 --> 00:44:23,960
+عليه بيأثر ال load ومعطيني ال reaction و ال moment
+
+358
+00:44:23,960 --> 00:44:31,070
+ومعطيني ال .. ال ..الشير at any location ومعطيني
+
+359
+00:44:31,070 --> 00:44:34,750
+ال moment at any location ومعطيني ال deflection و
+
+360
+00:44:34,750 --> 00:44:38,370
+ال maximum deflection طبعا عندى مجموعة من ال beams
+
+361
+00:44:38,370 --> 00:44:46,070
+المختلفة هذا ال table A9 يعني عندى طرق مختلفة
+
+362
+00:44:46,070 --> 00:44:47,350
+للتحميل ال beams
+
+363
+00:44:55,260 --> 00:45:00,240
+عندي حوالي عشر حالات، اتناشر حالة، تلاتاش،
+
+364
+00:45:00,240 --> 00:45:08,040
+اربعتاش، خمستاش، ستاش، حوالي ستاشر حالة تحميل
+
+365
+00:45:08,040 --> 00:45:12,120
+مختلفة، حوالي ستاشر حالة تحميل مختلفة
+
+366
+00:45:25,430 --> 00:45:30,190
+إذا بدك تفاصيل أكتر بتروح المرجع هذا rocks
+
+367
+00:45:30,190 --> 00:45:33,750
+formulas for stress and strain هتشوف حالات و
+
+368
+00:45:33,750 --> 00:45:37,430
+تفاصيل .. يعني هتشوف شغلات أكتر من اللي عرضنا في
+
+369
+00:45:37,430 --> 00:45:43,710
+ال appendix A9 لإن
+
+370
+00:45:43,710 --> 00:45:51,930
+هنشوف كيف نحلحسابات الـ deflection باستخدام اللي
+
+371
+00:45:51,930 --> 00:45:57,270
+هو ال superposition واستخدام الجداول نطلع على
+
+372
+00:45:57,270 --> 00:46:01,250
+المثال الحالي consider the uniformly loaded beam
+
+373
+00:46:01,250 --> 00:46:05,670
+with a concentrated force as shown في عند ال beam
+
+374
+00:46:05,670 --> 00:46:13,600
+فيه بأثر عليه حمل مركز F على بعد Aو فيه برضه بيأثر
+
+375
+00:46:13,600 --> 00:46:20,500
+عليه حمل موزع قيمته W ال beam طوله L ال beam is
+
+376
+00:46:20,500 --> 00:46:27,960
+simply supported عند نقطة A عند نقطة C using
+
+377
+00:46:27,960 --> 00:46:31,700
+superposition determine the reactions and
+
+378
+00:46:31,700 --> 00:46:35,100
+deflections as a function of X باستخدام ال
+
+379
+00:46:35,100 --> 00:46:40,940
+superposition أوجد ال deflectionsو ال slopes و ال
+
+380
+00:46:40,940 --> 00:46:43,980
+reactions as a function of x هذه المسألة مركبة
+
+381
+00:46:43,980 --> 00:46:59,940
+يعني عشان أحلها بدي أعتبر أنا عندي P F
+
+382
+00:46:59,940 --> 00:47:07,940
+و عندي هنا R1 و أنا عندي R2
+
+383
+00:47:09,430 --> 00:47:21,410
+و في كمان distributed load
+
+384
+00:47:21,410 --> 00:47:26,650
+هذا يمكن ان يعتبر عبارة كأنه two beams one beam
+
+385
+00:47:39,690 --> 00:47:50,530
+R1' R2' R2'
+
+386
+00:47:50,550 --> 00:48:03,290
+R2' R2' R2' R2' R2' R2' R2' R2'
+
+387
+00:48:06,210 --> 00:48:11,850
+R2W' هذه هي ال beam الأساسي عليه concentrated load
+
+388
+00:48:11,850 --> 00:48:15,870
+at this point F ويعني distributed load all over
+
+389
+00:48:15,870 --> 00:48:21,370
+the beam هذي يكون اعتبره كأنه عبارة عن مجموع and
+
+390
+00:48:21,370 --> 00:48:25,710
+it is مجموع two beams one beam has a concentrated
+
+391
+00:48:25,710 --> 00:48:30,670
+load F another beam has a distributed load W
+
+392
+00:48:33,520 --> 00:48:43,300
+الان انا هرجع و ال total reaction R1 بيكون سوى R1
+
+393
+00:48:43,300 --> 00:48:55,100
+prime زاد R1 double prime و R2 بيكون سوى R2 prime
+
+394
+00:48:55,100 --> 00:48:57,860
+زاد R2 double prime
+
+395
+00:49:11,920 --> 00:49:21,060
+الحالة الأولى هرجع لبندق ال four هذه نحكي هنا
+
+396
+00:49:21,060 --> 00:49:25,120
+refer to
+
+397
+00:49:25,120 --> 00:49:34,540
+appendix aتسعة ستة هاي A تسعة ستة عبارة هتبثل بيم
+
+398
+00:49:34,540 --> 00:49:40,760
+تحت أثير حمل المركز على بعد A وطول ال beam L
+
+399
+00:49:40,760 --> 00:49:49,020
+معطيني R واحد برايم بتساوي
+
+400
+00:49:49,020 --> 00:49:52,060
+FB على L
+
+401
+00:50:01,870 --> 00:50:13,930
+R2' FA على L مُعطين
+
+402
+00:50:13,930 --> 00:50:21,390
+الـ Deflection YAB
+
+403
+00:50:36,830 --> 00:50:49,950
+YAB' أو يسميها Y prime هتكون
+
+404
+00:50:49,950 --> 00:51:01,490
+عبارة عن جزءينهذا الجزء اللي هو FBX على
+
+405
+00:51:01,490 --> 00:51:17,050
+ستة EIL في X تربيع زائد B تربيع مانقس L تربيع طبعا
+
+406
+00:51:17,050 --> 00:51:29,820
+هذا X بين A و BX أكبر أو يساوي سفر وأقل من B و
+
+407
+00:51:29,820 --> 00:51:37,720
+بتساوي من B ل C FA في
+
+408
+00:51:37,720 --> 00:51:48,360
+L minus X على 6EIL في
+
+409
+00:51:48,360 --> 00:51:49,220
+X تربيع
+
+410
+00:51:51,610 --> 00:52:01,630
+زاد a تربيع ماقص 2LX طبعا
+
+411
+00:52:01,630 --> 00:52:10,310
+X أكبر أو يساوي هنا أكبر أو يساوي A
+
+412
+00:52:10,310 --> 00:52:15,690
+وأصغر من L
+
+413
+00:52:23,340 --> 00:52:29,960
+هذه المعادلات كلها
+
+414
+00:52:29,960 --> 00:52:37,080
+هي four concentrated load
+
+415
+00:52:37,080 --> 00:52:51,420
+اللي هو appendix A96 هذه الحالة التانية
+
+416
+00:52:51,420 --> 00:52:52,080
+اللي هي هذه
+
+417
+00:52:54,810 --> 00:53:03,690
+هنشوفها في أبندكس A97 هيكون
+
+418
+00:53:03,690 --> 00:53:08,270
+عندي R1 double prime R1
+
+419
+00:53:08,270 --> 00:53:16,270
+double prime بيستوى
+
+420
+00:53:16,270 --> 00:53:25,990
+WL على 2 بيستوى R2Double prime بيساوي WL على اتنين
+
+421
+00:53:25,990 --> 00:53:29,830
+وDeflection
+
+422
+00:53:29,830 --> 00:53:36,890
+Y بتساوي
+
+423
+00:53:36,890 --> 00:53:46,710
+WX على 24WX على 24EI
+
+424
+00:53:49,770 --> 00:53:55,350
+في 2LX تربية minus
+
+425
+00:53:55,350 --> 00:53:59,590
+X تكييب minus
+
+426
+00:53:59,590 --> 00:54:04,970
+L تكييب هذا
+
+427
+00:54:04,970 --> 00:54:12,950
+Y double prime الآن ال total effect ال total
+
+428
+00:54:12,950 --> 00:54:13,550
+effect
+
+429
+00:54:23,990 --> 00:54:32,490
+هيكون عندى ال R1 R1 prime زاد R1 double prime يعني
+
+430
+00:54:32,490 --> 00:54:36,490
+هيكون الساوية R1
+
+431
+00:54:36,490 --> 00:54:48,970
+prime اللي هي FB على L وR1 double prime زاد WL على
+
+432
+00:54:48,970 --> 00:54:57,060
+2 هذا ال total reaction و ال R2يستوى R2 prime زي
+
+433
+00:54:57,060 --> 00:55:07,300
+R2 double prime يعني هتكون FA على L زي
+
+434
+00:55:07,300 --> 00:55:15,440
+WL على 2 هذا لل reactions بالنسبة لل deflection ال
+
+435
+00:55:15,440 --> 00:55:21,060
+Y هتكون تستوى Y prime
+
+436
+00:55:23,850 --> 00:55:37,630
+زائد y double prime يعني ال y هتكون تساوي ال
+
+437
+00:55:37,630 --> 00:55:49,590
+y y prime هتكون
+
+438
+00:55:49,590 --> 00:55:51,090
+تساوي fbx
+
+439
+00:55:55,690 --> 00:56:07,090
+على ستة EI L في X تربية زائد B تربية minus L تربية
+
+440
+00:56:07,090 --> 00:56:25,050
+زائد WX على أربع و عشرين EI في اتنين L X تربية- X
+
+441
+00:56:25,050 --> 00:56:38,550
+تكييب- L تكييب هذا في حالة X بين Zero و A بين
+
+442
+00:56:38,550 --> 00:56:52,690
+B و C هتكون FA FA في L-X على 6EI
+
+443
+00:56:54,220 --> 00:57:06,760
+L في X تربيع زاد A تربيع ناقص 2LX زاد
+
+444
+00:57:06,760 --> 00:57:10,760
+WX
+
+445
+00:57:10,760 --> 00:57:23,590
+على 24EI في 2LX تربيعminus X تكييب minus L تكييب
+
+446
+00:57:23,590 --> 00:57:31,670
+هذا طبعا X بين B و C أكبر من A و أصغر من L هذا هو
+
+447
+00:57:31,670 --> 00:57:38,530
+ال total deflection
+
+448
+00:57:38,530 --> 00:57:43,910
+معناته
+
+449
+00:57:43,910 --> 00:57:48,210
+باستخدام ال source position جزأت المثلة هذا ال
+
+450
+00:57:48,210 --> 00:57:53,250
+total loadingعبارة عن مجموع two loading conditions
+
+451
+00:57:53,250 --> 00:57:56,170
+ال loading condition الأولى هي عبارة عن
+
+452
+00:57:56,170 --> 00:57:59,950
+concentrated load at point B و ال another loading
+
+453
+00:57:59,950 --> 00:58:02,630
+condition عبارة عن distributed load all over the
+
+454
+00:58:02,630 --> 00:58:10,050
+beam المحاضرة
+
+455
+00:58:10,050 --> 00:58:13,110
+الجاي بنكمل
+
diff --git a/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/E30F47W7ioI_raw.json b/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/E30F47W7ioI_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..84fb82f585b810553aa6189000be66fea77912d7
--- /dev/null
+++ b/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/E30F47W7ioI_raw.json
@@ -0,0 +1 @@
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"يعني لو كان عندى beam وعليه مثلا force في المصر هيكون ليه two reactions يعني reaction هنا f على 2 وهنا", "tokens": [40228, 22653, 45164, 25961, 43242, 7578, 14269, 4032, 3615, 20292, 3224, 50113, 15040, 3464, 8978, 9673, 9381, 2288, 8032, 1829, 30544, 32239, 3224, 732, 12215, 37495, 22653, 5480, 34105, 283, 15844, 568, 37037, 8315], "avg_logprob": -0.394196435383388, "compression_ratio": 1.2857142857142858, "no_speech_prob": 0.0, "words": [{"start": 862.83, "end": 863.11, "word": "يعني", "probability": 0.7314453125}, {"start": 863.11, "end": 863.27, "word": " لو", "probability": 0.953125}, {"start": 863.27, "end": 863.45, "word": " كان", "probability": 0.9365234375}, {"start": 863.45, "end": 863.97, "word": " عندى", "probability": 0.736083984375}, {"start": 863.97, "end": 865.15, "word": " beam", "probability": 0.8603515625}, {"start": 865.15, "end": 877.95, "word": " وعليه", "probability": 0.8070068359375}, {"start": 877.95, "end": 878.51, "word": " مثلا", "probability": 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95672, "start": 930.4, "end": 956.72, "text": "طبعا اذا كان هذا طوله L هذا هتكون طوله L على 2 هذا هتكون F L على 4 هذا ال moment دياجرام", "tokens": [9566, 3555, 3615, 995, 1975, 15730, 25961, 23758, 23032, 12610, 3224, 441, 23758, 8032, 2655, 30544, 23032, 12610, 3224, 441, 15844, 568, 23758, 8032, 2655, 30544, 479, 441, 15844, 1017, 23758, 2423, 1623, 11778, 1829, 26108, 2288, 10943], "avg_logprob": -0.23798077610822824, "compression_ratio": 1.4742268041237114, "no_speech_prob": 0.0, "words": [{"start": 930.4, "end": 930.76, "word": "طبعا", "probability": 0.95751953125}, {"start": 930.76, "end": 930.9, "word": " اذا", "probability": 0.7265625}, {"start": 930.9, "end": 931.1, "word": " كان", "probability": 0.9921875}, {"start": 931.1, "end": 931.26, "word": " هذا", "probability": 0.86474609375}, {"start": 931.26, "end": 931.58, "word": " طوله", "probability": 0.8831380208333334}, {"start": 931.58, "end": 931.82, "word": " L", "probability": 0.794921875}, {"start": 931.82, "end": 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"word": " at", "probability": 0.8408203125}, {"start": 1013.12, "end": 1014.48, "word": " a", "probability": 0.98486328125}, {"start": 1014.48, "end": 1014.84, "word": " given", "probability": 0.90625}, {"start": 1014.84, "end": 1017.88, "word": " point", "probability": 0.982421875}], "temperature": 1.0}, {"id": 36, "seek": 104798, "start": 1020.04, "end": 1047.98, "text": "on the beam و M هي ال moment ال course of ending moment at the given section", "tokens": [266, 264, 14269, 4032, 376, 39896, 2423, 1623, 2423, 1164, 295, 8121, 1623, 412, 264, 2212, 3541], "avg_logprob": -0.4123264021343655, "compression_ratio": 1.064102564102564, "no_speech_prob": 0.0, "words": [{"start": 1020.04, "end": 1020.4, "word": "on", "probability": 0.62939453125}, {"start": 1020.4, "end": 1020.6, "word": " the", "probability": 0.89599609375}, {"start": 1020.6, "end": 1020.84, "word": " beam", "probability": 0.9375}, {"start": 1020.84, "end": 1027.48, "word": " و", "probability": 0.444091796875}, {"start": 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0.7119140625}, {"start": 1140.01, "end": 1140.33, "word": " نقطة", "probability": 0.8203125}, {"start": 1140.33, "end": 1140.67, "word": " هذه", "probability": 0.6318359375}, {"start": 1140.67, "end": 1141.77, "word": " هذا", "probability": 0.1939697265625}, {"start": 1141.77, "end": 1141.91, "word": " ال", "probability": 0.90576171875}, {"start": 1141.91, "end": 1142.35, "word": " slope", "probability": 0.8896484375}, {"start": 1142.35, "end": 1144.81, "word": " dy", "probability": 0.31787109375}, {"start": 1144.81, "end": 1146.33, "word": " by", "probability": 0.80322265625}, {"start": 1146.33, "end": 1146.83, "word": " dx", "probability": 0.9736328125}], "temperature": 1.0}, {"id": 40, "seek": 117761, "start": 1149.02, "end": 1177.62, "text": "إذا كان الـ deflection صغير كتير for small slopes of the deflected beam بيكون عندي dy by dx", "tokens": [28814, 15730, 25961, 2423, 39184, 1060, 5450, 20328, 17082, 13546, 9122, 2655, 13546, 337, 1359, 37725, 295, 264, 41373, 292, 14269, 4724, 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عشرين انش ال beam is simply supported at the end", "tokens": [6027, 343, 12174, 32640, 2655, 11296, 6055, 2304, 7649, 9957, 12013, 3464, 5296, 28820, 16472, 8592, 2423, 14269, 23032, 12610, 3224, 6225, 46309, 9957, 16472, 8592, 2423, 14269, 307, 2935, 8104, 412, 264, 917], "avg_logprob": -0.2091517789023263, "compression_ratio": 1.182608695652174, "no_speech_prob": 0.0, "words": [{"start": 1417.45, "end": 1417.75, "word": "ال", "probability": 0.791015625}, {"start": 1417.75, "end": 1418.05, "word": " W", "probability": 0.32568359375}, {"start": 1418.05, "end": 1418.73, "word": " قيمتها", "probability": 0.963134765625}, {"start": 1418.73, "end": 1421.49, "word": " تمانين", "probability": 0.7947998046875}, {"start": 1421.49, "end": 1421.91, "word": " pound", "probability": 0.669921875}, {"start": 1421.91, "end": 1422.57, "word": " force", "probability": 0.890625}, {"start": 1422.57, "end": 1423.15, "word": " لكل", "probability": 0.96728515625}, {"start": 1423.15, "end": 1423.75, "word": 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اربعة واحد اتنين تلاتة اربعة أسفار في ستاش ع تلاتة في EI", "tokens": [40228, 22653, 1975, 8315, 8032, 2655, 30544, 1975, 25513, 27884, 43242, 9957, 1975, 2655, 1863, 9957, 1975, 2655, 1863, 9957, 1975, 25513, 27884, 36764, 24401, 1975, 2655, 1863, 9957, 6055, 1211, 9307, 3660, 1975, 25513, 27884, 5551, 3794, 5172, 9640, 8978, 8608, 2655, 33599, 6225, 6055, 1211, 9307, 3660, 8978, 462, 40], "avg_logprob": -0.16922170036243941, "compression_ratio": 1.7, "no_speech_prob": 0.0, "words": [{"start": 2197.49, "end": 2197.79, "word": "يعني", "probability": 0.939453125}, {"start": 2197.79, "end": 2197.91, "word": " انا", "probability": 0.68505859375}, {"start": 2197.91, "end": 2198.71, "word": " هتكون", "probability": 0.9012044270833334}, {"start": 2198.71, "end": 2206.35, "word": " اربعة", "probability": 0.7809244791666666}, {"start": 2206.35, "end": 2209.19, "word": " عندين", "probability": 0.5264892578125}, {"start": 2209.19, "end": 2209.83, "word": " اتنين", "probability": 0.9661865234375}, 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{"start": 2306.0, "end": 2306.44, "word": " تربية", "probability": 0.9763997395833334}, {"start": 2306.44, "end": 2308.12, "word": " هذه", "probability": 0.91162109375}, {"start": 2308.12, "end": 2308.52, "word": " X", "probability": 0.97119140625}, {"start": 2308.52, "end": 2309.28, "word": " تكيب", "probability": 0.867919921875}, {"start": 2309.28, "end": 2313.38, "word": " زائد", "probability": 0.861328125}, {"start": 2313.38, "end": 2314.14, "word": " أربعمية", "probability": 0.9404296875}], "temperature": 1.0}, {"id": 79, "seek": 233760, "start": 2315.62, "end": 2337.6, "text": "فى 16 ع 3EI طبعا المعادلة هذه بتعطى deflection anywhere and at any x و المعادلة التانية بتعطى slope", "tokens": [5172, 7578, 3165, 6225, 805, 36, 40, 23032, 3555, 3615, 995, 9673, 3615, 18513, 37977, 29538, 39894, 3615, 9566, 7578, 1060, 5450, 4992, 293, 412, 604, 2031, 4032, 9673, 3615, 18513, 37977, 16712, 7649, 10632, 39894, 3615, 9566, 7578, 13525], "avg_logprob": -0.27953505516052246, 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"text": "معين متنوع ممكن اجزء ال effect يعني ال total effect عبارة عن مجموع individual effects و بستخدم اللي هي ال beef deflection formulas من ال appendix A9 اذا بنفتح الكتاب على ال appendix A9", "tokens": [2304, 3615, 9957, 44650, 1863, 45367, 3714, 43020, 1975, 7435, 11622, 38207, 2423, 1802, 37495, 22653, 2423, 3217, 1802, 6225, 3555, 9640, 3660, 18871, 3714, 7435, 2304, 45367, 2609, 5065, 4032, 4724, 14851, 9778, 40448, 13672, 1829, 39896, 2423, 9256, 1060, 5450, 30546, 9154, 2423, 34116, 970, 316, 24, 1975, 15730, 44945, 5172, 2655, 5016, 33251, 2655, 16758, 15844, 2423, 34116, 970, 316, 24], "avg_logprob": -0.19663461538461538, "compression_ratio": 1.463276836158192, "no_speech_prob": 2.980232238769531e-07, "words": [{"start": 2615.07, "end": 2615.69, "word": "معين", "probability": 0.9503580729166666}, {"start": 2615.69, "end": 2616.41, "word": " متنوع", "probability": 0.7933756510416666}, {"start": 2616.41, "end": 2617.49, "word": " ممكن", "probability": 0.974609375}, {"start": 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حمل مركز F على بعد A", "tokens": [5016, 3794, 16758, 9307, 2423, 39184, 1060, 5450, 4724, 995, 14851, 9778, 3215, 10943, 13672, 1829, 31439, 2423, 1687, 38078, 36764, 14851, 9778, 3215, 10943, 25724, 28259, 12610, 8717, 9566, 1211, 3615, 15844, 9673, 12984, 6027, 21542, 6027, 1829, 1949, 264, 48806, 13210, 14269, 365, 257, 21321, 3464, 382, 4898, 8978, 43242, 2423, 14269, 8978, 3224, 4724, 10721, 49115, 47356, 11331, 42213, 3714, 31747, 11622, 479, 15844, 39182, 316], "avg_logprob": -0.1858258871095521, "compression_ratio": 1.4878048780487805, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 2746.99, "end": 2747.87, "word": "حسابات", "probability": 0.9625244140625}, {"start": 2747.87, "end": 2748.21, "word": " الـ", "probability": 0.864990234375}, {"start": 2748.21, "end": 2748.81, "word": " deflection", "probability": 0.724365234375}, {"start": 2748.81, "end": 2750.87, "word": " باستخدام", "probability": 0.97705078125}, {"start": 2750.87, "end": 2751.93, "word": " اللي", 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" reactions", "probability": 0.75830078125}, {"start": 2791.24, "end": 2791.7, "word": " and", "probability": 0.9599609375}, {"start": 2791.7, "end": 2792.48, "word": " deflections", "probability": 0.94677734375}, {"start": 2792.48, "end": 2792.74, "word": " as", "probability": 0.9375}, {"start": 2792.74, "end": 2792.86, "word": " a", "probability": 0.91748046875}, {"start": 2792.86, "end": 2793.24, "word": " function", "probability": 0.97265625}, {"start": 2793.24, "end": 2793.58, "word": " of", "probability": 0.97412109375}, {"start": 2793.58, "end": 2793.98, "word": " X", "probability": 0.69482421875}, {"start": 2793.98, "end": 2794.98, "word": " باستخدام", "probability": 0.9859212239583334}, {"start": 2794.98, "end": 2795.1, "word": " ال", "probability": 0.56884765625}, {"start": 2795.1, "end": 2796.52, "word": " superposition", "probability": 0.953857421875}, {"start": 2796.52, "end": 2797.8, "word": " أوجد", "probability": 0.8092447916666666}, {"start": 2797.8, "end": 2798.24, 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2846.25, "end": 2846.65, "word": " beam", "probability": 0.96728515625}], "temperature": 1.0}, {"id": 98, "seek": 288329, "start": 2859.69, "end": 2883.29, "text": "R1' R2' R2' R2' R2' R2' R2' R2' R2' R2' R2'", "tokens": [49, 16, 6, 497, 17, 6, 497, 17, 6, 497, 17, 6, 497, 17, 6, 497, 17, 6, 497, 17, 6, 497, 17, 6, 497, 17, 6, 497, 17, 6, 497, 17, 6], "avg_logprob": -0.48253676733549905, "compression_ratio": 2.6875, "no_speech_prob": 4.172325134277344e-07, "words": [{"start": 2859.6899999999996, "end": 2861.0899999999997, "word": "R1'", "probability": 0.45196533203125}, {"start": 2861.0899999999997, "end": 2862.49, "word": " R2'", "probability": 0.58856201171875}, {"start": 2863.19, "end": 2870.53, "word": " R2'", "probability": 0.4079132080078125}, {"start": 2870.55, "end": 2871.79, "word": " R2'", "probability": 0.53955078125}, {"start": 2872.51, "end": 2874.73, "word": " R2'", "probability": 0.6143798828125}, {"start": 2875.19, "end": 2875.19, "word": " R2'", "probability": 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"probability": 0.65673828125}, {"start": 2903.05, "end": 2903.43, "word": " beams", "probability": 0.966796875}, {"start": 2903.43, "end": 2903.95, "word": " one", "probability": 0.5556640625}, {"start": 2903.95, "end": 2904.31, "word": " beam", "probability": 0.93115234375}, {"start": 2904.31, "end": 2904.97, "word": " has", "probability": 0.919921875}, {"start": 2904.97, "end": 2905.21, "word": " a", "probability": 0.8486328125}, {"start": 2905.21, "end": 2905.71, "word": " concentrated", "probability": 0.97265625}, {"start": 2905.71, "end": 2906.07, "word": " load", "probability": 0.97802734375}, {"start": 2906.07, "end": 2906.63, "word": " F", "probability": 0.916015625}, {"start": 2906.63, "end": 2907.53, "word": " another", "probability": 0.53759765625}, {"start": 2907.53, "end": 2907.91, "word": " beam", "probability": 0.95361328125}, {"start": 2907.91, "end": 2908.29, "word": " has", "probability": 0.93017578125}, {"start": 2908.29, "end": 2908.51, "word": " a", "probability": 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"temperature": 1.0}, {"id": 101, "seek": 296686, "start": 2951.92, "end": 2966.86, "text": "الحالة الأولى هرجع لبندق ال four هذه نحكي هنا refer to appendix a", "tokens": [6027, 5016, 6027, 3660, 16247, 12610, 7578, 8032, 47341, 3615, 5296, 3555, 1863, 3215, 4587, 2423, 1451, 29538, 8717, 5016, 4117, 1829, 34105, 2864, 281, 34116, 970, 257], "avg_logprob": -0.46282327997273415, "compression_ratio": 1.053763440860215, "no_speech_prob": 0.0, "words": [{"start": 2951.92, "end": 2953.32, "word": "الحالة", "probability": 0.67767333984375}, {"start": 2953.32, "end": 2953.94, "word": " الأولى", "probability": 0.92724609375}, {"start": 2953.94, "end": 2955.1, "word": " هرجع", "probability": 0.8307291666666666}, {"start": 2955.1, "end": 2955.82, "word": " لبندق", "probability": 0.51318359375}, {"start": 2955.82, "end": 2955.86, "word": " ال", "probability": 0.6103515625}, {"start": 2955.86, "end": 2956.34, "word": " four", "probability": 0.302490234375}, {"start": 2956.34, "end": 2958.26, 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3434.72, "word": " 24EI", "probability": 0.869140625}, {"start": 3434.72, "end": 3436.54, "word": " في", "probability": 0.94677734375}, {"start": 3436.54, "end": 3438.32, "word": " 2LX", "probability": 0.875}, {"start": 3438.32, "end": 3438.96, "word": " تربيع", "probability": 0.950927734375}], "temperature": 1.0}, {"id": 118, "seek": 346899, "start": 3439.73, "end": 3468.99, "text": "minus X تكييب minus L تكييب هذا طبعا X بين B و C أكبر من A و أصغر من L هذا هو ال total deflection معناته باستخدام ال source position جزأت المثلة هذا ال total loading", "tokens": [2367, 301, 1783, 6055, 4117, 1829, 1829, 3555, 3175, 441, 6055, 4117, 1829, 1829, 3555, 23758, 23032, 3555, 3615, 995, 1783, 49374, 363, 4032, 383, 5551, 4117, 26890, 9154, 316, 4032, 5551, 9381, 17082, 2288, 9154, 441, 23758, 31439, 2423, 3217, 1060, 5450, 20449, 8315, 47395, 4724, 995, 14851, 9778, 3215, 10943, 2423, 4009, 2535, 10874, 11622, 10721, 2655, 9673, 12984, 37977, 23758, 2423, 3217, 15114], "avg_logprob": 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total", "probability": 0.69189453125}, {"start": 3453.19, "end": 3458.53, "word": " deflection", "probability": 0.90234375}, {"start": 3458.53, "end": 3463.91, "word": " معناته", "probability": 0.8021647135416666}, {"start": 3463.91, "end": 3464.65, "word": " باستخدام", "probability": 0.9845377604166666}, {"start": 3464.65, "end": 3464.79, "word": " ال", "probability": 0.38671875}, {"start": 3464.79, "end": 3464.95, "word": " source", "probability": 0.1669921875}, {"start": 3464.95, "end": 3465.47, "word": " position", "probability": 0.95556640625}, {"start": 3465.47, "end": 3467.21, "word": " جزأت", "probability": 0.681396484375}, {"start": 3467.21, "end": 3467.73, "word": " المثلة", "probability": 0.8390299479166666}, {"start": 3467.73, "end": 3468.07, "word": " هذا", "probability": 0.87646484375}, {"start": 3468.07, "end": 3468.21, "word": " ال", "probability": 0.89599609375}, {"start": 3468.21, "end": 3468.45, "word": " total", "probability": 0.84716796875}, {"start": 3468.45, 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"probability": 0.9091796875}, {"start": 3476.69, "end": 3477.05, "word": " load", "probability": 0.97216796875}, {"start": 3477.05, "end": 3477.25, "word": " at", "probability": 0.9443359375}, {"start": 3477.25, "end": 3477.53, "word": " point", "probability": 0.72119140625}, {"start": 3477.53, "end": 3477.85, "word": " B", "probability": 0.84033203125}, {"start": 3477.85, "end": 3478.97, "word": " و", "probability": 0.689453125}, {"start": 3478.97, "end": 3479.11, "word": " ال", "probability": 0.57861328125}, {"start": 3479.11, "end": 3479.43, "word": " another", "probability": 0.89892578125}, {"start": 3479.43, "end": 3479.95, "word": " loading", "probability": 0.89453125}, {"start": 3479.95, "end": 3480.47, "word": " condition", "probability": 0.96875}, {"start": 3480.47, "end": 3480.83, "word": " عبارة", "probability": 0.994873046875}, {"start": 3480.83, "end": 3481.01, "word": " عن", "probability": 0.99365234375}, {"start": 3481.01, "end": 3481.41, "word": " distributed", 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\ No newline at end of file
diff --git a/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/E30F47W7ioI_raw.srt b/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/E30F47W7ioI_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..6e432f800382b1e6d63603d5cd4d331994eba7db
--- /dev/null
+++ b/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/E30F47W7ioI_raw.srt
@@ -0,0 +1,1832 @@
+1
+00:00:04,980 --> 00:00:07,400
+بسم الله الرحمن الرحيم السلام عليكم و رحمة الله
+
+2
+00:00:07,400 --> 00:00:10,720
+اليوم هنبدأ chapter جديد اللي هو هيكون على
+
+3
+00:00:10,720 --> 00:00:15,120
+deflection and stiffness of mechanical elements ال
+
+4
+00:00:15,120 --> 00:00:18,120
+chapter الفاتر احنا درسنا اللي هو stress analysis
+
+5
+00:00:18,120 --> 00:00:22,480
+of mechanical elements اليوم في ال chapter هذا
+
+6
+00:00:22,480 --> 00:00:26,800
+هندرس اللي هو spring ratesالـ tension و ال
+
+7
+00:00:26,800 --> 00:00:31,220
+deflection due to tension, compression and torsion
+
+8
+00:00:31,220 --> 00:00:34,840
+و برضه ال spring rate due to tension, compression
+
+9
+00:00:34,840 --> 00:00:43,840
+and torsion حدث ال deflection due to bendingهنتعرف
+
+10
+00:00:43,840 --> 00:00:46,800
+على طرق لحسابات ال deflection منها ال
+
+11
+00:00:46,800 --> 00:00:49,600
+superposition ال straight energy ال castellano
+
+12
+00:00:49,600 --> 00:00:53,940
+theorem بعدها هنتعرف على deflection of curved
+
+13
+00:00:53,940 --> 00:00:59,120
+members بعدها هنتعرف كيف نحل المسائل بتكون غير
+
+14
+00:00:59,120 --> 00:01:02,180
+قابلة لحل بالطرق التقليدية اللي هي statically
+
+15
+00:01:02,180 --> 00:01:06,180
+indeterminate problems بعدها هندرس ظاهرة ال
+
+16
+00:01:06,180 --> 00:01:09,220
+buckling او ال compression of mechanical members
+
+17
+00:01:09,960 --> 00:01:15,700
+اللي هي ظاهرة الانبعاج في الأعمدة نتيجة أنه متعرض
+
+18
+00:01:15,700 --> 00:01:20,160
+لقوة انضغاط طبعا قوة الانضغاط ممكن تكون مركزية
+
+19
+00:01:20,160 --> 00:01:24,700
+يعني بتمر في محور المنبر أو غير مركزية بتمرش في
+
+20
+00:01:24,700 --> 00:01:25,240
+المحور
+
+21
+00:01:28,120 --> 00:01:33,800
+هنبدأ بالبعض المفاهيم البسيطة كتقديم لهذا ال
+
+22
+00:01:33,800 --> 00:01:38,960
+chapter هنعرف ال elasticity و هنعرف ال spring ال
+
+23
+00:01:38,960 --> 00:01:44,340
+elasticity او اليونة للمادة هي خاصية للمادة
+
+24
+00:01:44,340 --> 00:01:49,760
+بتمكنها من استرجاع شكلها الأصليطبعا اي mechanical
+
+25
+00:01:49,760 --> 00:01:55,520
+element اتعرض لقوة بيصير فيه deformation if this
+
+26
+00:01:55,520 --> 00:01:59,600
+mechanical element is elastic then it will regain
+
+27
+00:01:59,600 --> 00:02:03,460
+its original shape before deformation upon
+
+28
+00:02:03,460 --> 00:02:07,220
+removing the load يعني هذه هي ظاهرة ال elasticity
+
+29
+00:02:07,220 --> 00:02:13,700
+ظاهرة او خاصية للمادة بتمكنها من استرجاع شكلها اذا
+
+30
+00:02:13,700 --> 00:02:19,980
+رفعت الحمل عنها فين دي ال springال spring أو
+
+31
+00:02:19,980 --> 00:02:23,720
+الزنبارك ال spring is a mechanical element that
+
+32
+00:02:23,720 --> 00:02:26,900
+exerts a force when deformed يعني إذا عند زنبارك
+
+33
+00:02:26,900 --> 00:02:32,060
+ضغطه أكيد هستيلي عليه قوة ضغط من زنبارك على إيدي
+
+34
+00:02:32,060 --> 00:02:37,020
+إذا سحبته هحاول يرجّهني لوضع الأصل معناته due to
+
+35
+00:02:37,020 --> 00:02:44,680
+deforming the spring it exerts a force ال
+
+36
+00:02:44,680 --> 00:02:51,290
+spring ريت من ال physics معرف ال Kas a function of
+
+37
+00:02:51,290 --> 00:03:00,310
+y بساوية dF by dy المعنى انت ال spring rate او ال
+
+38
+00:03:00,310 --> 00:03:07,450
+spring constant يعني بيعبر عن how much force I
+
+39
+00:03:07,450 --> 00:03:16,850
+need to deflect Delta Y اذا عند زنبراك اثرت
+
+40
+00:03:16,850 --> 00:03:18,370
+عليه force F
+
+41
+00:03:23,190 --> 00:03:27,610
+هيصير فيه ايش؟
+
+42
+00:03:27,610 --> 00:03:31,890
+Deflection قيمته
+
+43
+00:03:31,890 --> 00:03:39,630
+Delta Y معناته
+
+44
+00:03:39,630 --> 00:03:46,030
+if I increase ال force then I have to decrease the
+
+45
+00:03:46,030 --> 00:03:50,070
+deflection او اذا زودت ال deflection لازم ازود ال
+
+46
+00:03:50,070 --> 00:03:55,940
+forceإذا كان دي ال spring linear يعني ال spring
+
+47
+00:03:55,940 --> 00:04:04,760
+force هاي ال Y و هاي ال F تتغير بشكل خط مع ال
+
+48
+00:04:04,760 --> 00:04:12,460
+deflection بيكون ال K بيستوي
+
+49
+00:04:12,460 --> 00:04:18,400
+F على Y هذا for linear spring
+
+50
+00:04:27,570 --> 00:04:32,550
+طبعا كل mechanical element له spring constant حتى
+
+51
+00:04:32,550 --> 00:04:37,910
+له مش دمبرك ال spring constant حسابه بيعتمد على
+
+52
+00:04:37,910 --> 00:04:44,110
+طبيعة ال loading اول حالة هناخدها اذا كان عندي
+
+53
+00:04:44,110 --> 00:04:50,930
+mechanical element under axial
+
+54
+00:04:50,930 --> 00:04:51,450
+loading
+
+55
+00:04:56,040 --> 00:05:14,720
+و هذا originally في البداية كان طوله L المقطع
+
+56
+00:05:14,720 --> 00:05:25,080
+التبعه cross sectional area
+
+57
+00:05:26,880 --> 00:05:34,140
+بتساوي A نتيجة ال force F هيصير عنده stress ال
+
+58
+00:05:34,140 --> 00:05:42,060
+stress هيكون بساوية sigma بساوية F على A ال
+
+59
+00:05:42,060 --> 00:05:46,020
+F اللي هي ال axial force وال A مساحة المقطع وإذا
+
+60
+00:05:46,020 --> 00:05:52,320
+كنت في ال elastic region هيكون بساوية E في أبسلون
+
+61
+00:05:52,320 --> 00:05:54,180
+E هي ال modulus
+
+62
+00:05:58,780 --> 00:06:10,280
+of elasticity معامل المرونة و epsilon ال strain و
+
+63
+00:06:10,280 --> 00:06:16,740
+had this relation valid
+
+64
+00:06:16,740 --> 00:06:20,900
+only
+
+65
+00:06:20,900 --> 00:06:25,720
+in the elastic range
+
+66
+00:06:30,760 --> 00:06:44,980
+الـ Strain بيساوي اللي هو Delta L على L يعني
+
+67
+00:06:44,980 --> 00:06:52,900
+هنا هسير عندى Sigma بيساوي F على A بيساوي E في
+
+68
+00:06:52,900 --> 00:06:55,420
+Delta L على
+
+69
+00:06:57,200 --> 00:07:05,800
+L خلينا نسميها Delta L يعني احنا سيراندي F على A
+
+70
+00:07:05,800 --> 00:07:15,540
+بسوء E في Delta على L يعني
+
+71
+00:07:15,540 --> 00:07:22,840
+احنا سيراندي F بسوء A E على L
+
+72
+00:07:25,650 --> 00:07:30,310
+في delta احنا نشوف ال .. ال .. ال .. ال .. ال ..
+
+73
+00:07:30,310 --> 00:07:32,050
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+74
+00:07:32,050 --> 00:07:32,050
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+75
+00:07:32,050 --> 00:07:32,050
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+76
+00:07:32,050 --> 00:07:33,430
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+77
+00:07:33,430 --> 00:07:33,530
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+78
+00:07:33,530 --> 00:07:34,650
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+79
+00:07:34,650 --> 00:07:36,210
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+80
+00:07:36,210 --> 00:07:40,750
+.. ال .. ال .. ال .. ال ..
+
+81
+00:07:40,750 --> 00:07:42,050
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+82
+00:07:42,050 --> 00:07:42,050
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+83
+00:07:42,050 --> 00:07:42,110
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+84
+00:07:42,110 --> 00:07:42,610
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+85
+00:07:42,610 --> 00:07:47,090
+ال .. ال .. ال ..
+
+86
+00:07:47,090 --> 00:07:51,230
+ال .. ال ..
+
+87
+00:07:55,790 --> 00:08:01,870
+و هذا deflection
+
+88
+00:08:01,870 --> 00:08:09,070
+معناته هذا ال term هذا
+
+89
+00:08:09,070 --> 00:08:12,930
+force و
+
+90
+00:08:12,930 --> 00:08:19,250
+هذا deflection معناته
+
+91
+00:08:19,250 --> 00:08:25,230
+هذا ايش هيكون؟ K معناته فيmechanical element under
+
+92
+00:08:25,230 --> 00:08:29,370
+axial loading سواء كان tension or compression
+
+93
+00:08:29,370 --> 00:08:41,850
+هيكون F بالساوية K في Delta where K بالساوية A في
+
+94
+00:08:41,850 --> 00:08:47,190
+E على L المعنى هو إذا عندي mechanical element
+
+95
+00:08:47,190 --> 00:08:54,740
+under axial loading ممكن اعتبره زنبركالزمبارك ال
+
+96
+00:08:54,740 --> 00:08:58,600
+spring rate هو given by a في e على l ال a اللي هي
+
+97
+00:08:58,600 --> 00:09:03,760
+مساحة المقطع ال e اللي هي modulus of elasticity و
+
+98
+00:09:03,760 --> 00:09:14,220
+ال l اللي هي طول ال mechanical element بالنسبة
+
+99
+00:09:14,220 --> 00:09:18,160
+لل torsion اللي هي loaded member
+
+100
+00:09:29,160 --> 00:09:34,460
+for a torrentially loaded member فهيكون عنده لو
+
+101
+00:09:34,460 --> 00:09:53,420
+افترضت انه مقطع مدور و
+
+102
+00:09:53,420 --> 00:10:08,820
+under بيأثر عليه torqueT حسين
+
+103
+00:10:08,820 --> 00:10:17,780
+دي اللي هي angular deflection ثتا
+
+104
+00:10:19,970 --> 00:10:24,470
+احنا من شبطر تلاتة حسبنا theta هذا فحسب theta
+
+105
+00:10:24,470 --> 00:10:37,690
+بتساوي T في L على G في J يعني الـ T بتساوي G في G
+
+106
+00:10:37,690 --> 00:10:47,170
+على L في Theta الـ G اللي هي ال modulus G modulus
+
+107
+00:10:50,610 --> 00:10:56,770
+of rigidity أو
+
+108
+00:10:56,770 --> 00:11:05,010
+ممكن نسمي الـ shear modulus shear modulus و
+
+109
+00:11:05,010 --> 00:11:14,210
+ال J ال polar moment of
+
+110
+00:11:14,210 --> 00:11:14,750
+inertia
+
+111
+00:11:18,170 --> 00:11:26,050
+of the cross section و
+
+112
+00:11:26,050 --> 00:11:32,990
+ال L ال
+
+113
+00:11:32,990 --> 00:11:38,690
+L ال length و
+
+114
+00:11:38,690 --> 00:11:45,770
+ال theta ال angular deflection
+
+115
+00:12:03,080 --> 00:12:10,980
+هأخدها تحت هنا ال torque بالساوية جي في جي على ال
+
+116
+00:12:10,980 --> 00:12:18,080
+في ثيتا و اتداخل حالة ال axis loading member
+
+117
+00:12:18,080 --> 00:12:22,180
+cannon دي ال F بالساوية
+
+118
+00:12:22,180 --> 00:12:32,080
+A في E على L في دلتا في حالة الحركة الخطية بيكون
+
+119
+00:12:32,080 --> 00:12:38,370
+دي forceفي حالة عندي rotation twist بيكون دي
+
+120
+00:12:38,370 --> 00:12:44,830
+torgen او torque في
+
+121
+00:12:44,830 --> 00:12:50,490
+حالة الحركة الخطية بيصير عندي ايش؟ deflection في
+
+122
+00:12:50,490 --> 00:12:55,750
+حالة ال rotation بيصير عندي ايش؟ angle مع أن
+
+123
+00:12:55,750 --> 00:12:59,290
+الناتوا هدول المعادلتين ماخدين نفس الشكل معناته ال
+
+124
+00:12:59,290 --> 00:13:03,290
+torque بالساوية
+
+125
+00:13:04,420 --> 00:13:12,540
+K في theta K هي ال stiffness او ال K هي ال spring
+
+126
+00:13:12,540 --> 00:13:15,260
+rate لتورجن ال loaded member
+
+127
+00:13:17,880 --> 00:13:23,080
+اللي هي هتكون تستوى G في J على L المعنى بتقول ال
+
+128
+00:13:23,080 --> 00:13:26,860
+spring constant او ال spring rate for a
+
+129
+00:13:26,860 --> 00:13:30,380
+torsionally loaded member is given by this
+
+130
+00:13:30,380 --> 00:13:35,440
+relation اللي هو G J على L يعني كل ما زادت ال
+
+131
+00:13:35,440 --> 00:13:39,760
+shear modulus او modulus of .. ال modulus of
+
+132
+00:13:39,760 --> 00:13:44,140
+rigidity كل ما زادت ال K كل ما كان المقطع أكبر
+
+133
+00:13:44,140 --> 00:13:50,210
+يعني .. يعني صعب انه اعملهrotation برضه ال K
+
+134
+00:13:50,210 --> 00:13:54,430
+بالزيد كل ما كان الاشي طويل اكتر اسهل ان اعمله ايش
+
+135
+00:13:54,430 --> 00:14:03,910
+اعمله deflection طيب
+
+136
+00:14:03,910 --> 00:14:15,550
+هندرس الآن ال deflection due
+
+137
+00:14:15,550 --> 00:14:16,490
+to bending load
+
+138
+00:14:22,830 --> 00:14:37,950
+يعني لو كان عندى beam وعليه
+
+139
+00:14:37,950 --> 00:14:45,990
+مثلا force في المصر هيكون
+
+140
+00:14:45,990 --> 00:14:53,750
+ليه two reactions يعني reaction هنا f على 2 وهناف
+
+141
+00:14:53,750 --> 00:15:00,270
+على اتنين لو ارسم ال shear diagram ال
+
+142
+00:15:00,270 --> 00:15:12,550
+shear diagram هيكون بالشكل هذا هذه
+
+143
+00:15:12,550 --> 00:15:20,050
+f على اتنين هذه minus f على اتنين و ال moment
+
+144
+00:15:20,050 --> 00:15:20,550
+diagram
+
+145
+00:15:30,400 --> 00:15:38,340
+طبعا اذا كان هذا طوله L هذا
+
+146
+00:15:38,340 --> 00:15:46,200
+هتكون طوله L على 2 هذا
+
+147
+00:15:46,200 --> 00:15:50,880
+هتكون F L على
+
+148
+00:15:50,880 --> 00:15:56,720
+4 هذا ال moment دياجرام
+
+149
+00:16:00,000 --> 00:16:04,300
+و هذا ال shear diagram
+
+150
+00:16:04,300 --> 00:16:07,660
+احنا
+
+151
+00:16:07,660 --> 00:16:12,560
+في شبطر تلاتة فكنا
+
+152
+00:16:12,560 --> 00:16:18,500
+طبعا هذا هسيرله ايش؟ هسيره deflection هسير بالشكل
+
+153
+00:16:18,500 --> 00:16:24,540
+هذا النقطة معينة هي radius of curvature هذا رو
+
+154
+00:16:24,540 --> 00:16:41,480
+فاندي واحد على روبالساوية M على E في I رو
+
+155
+00:16:41,480 --> 00:16:47,800
+هو ال radius of
+
+156
+00:16:47,800 --> 00:16:53,120
+curvature at
+
+157
+00:16:53,120 --> 00:16:57,880
+a given point
+
+158
+00:17:00,040 --> 00:17:07,480
+on the beam و
+
+159
+00:17:07,480 --> 00:17:18,000
+M هي ال moment ال course of ending moment
+
+160
+00:17:18,000 --> 00:17:21,220
+at
+
+161
+00:17:21,220 --> 00:17:27,980
+the given section
+
+162
+00:17:32,750 --> 00:17:45,030
+و ال E اللي هو معامل مرونا Modulus of elasticity و
+
+163
+00:17:45,030 --> 00:17:49,630
+ال I ال
+
+164
+00:17:49,630 --> 00:17:58,230
+momentum inertia of
+
+165
+00:17:58,230 --> 00:17:58,930
+the section
+
+166
+00:18:07,360 --> 00:18:12,720
+الان from calculus احنا بنعرف في علاقة الان ال
+
+167
+00:18:12,720 --> 00:18:16,060
+radius of curvature او ال .. او ال واحدة ل روه
+
+168
+00:18:16,060 --> 00:18:22,060
+بيعطيه علاقة مشتقتين d square y by dx square على
+
+169
+00:18:22,060 --> 00:18:31,800
+واحد زي ال dy على dx الكل تربيع از تلاتة على اتنين
+
+170
+00:18:31,800 --> 00:18:36,000
+يعني هنا بدك تعرف تفاصيل اكتر
+
+171
+00:18:38,670 --> 00:18:48,950
+back to calculus يعني
+
+172
+00:18:48,950 --> 00:18:55,010
+إذا كان هذا هو ال X و
+
+173
+00:18:55,010 --> 00:19:06,330
+هذا هو ال Y معناته عند نقطة هذه هذا ال slope dy by
+
+174
+00:19:06,330 --> 00:19:17,640
+dxإذا كان الـ deflection صغير كتير for small
+
+175
+00:19:17,640 --> 00:19:21,840
+slopes
+
+176
+00:19:21,840 --> 00:19:34,280
+of the deflected beam بيكون
+
+177
+00:19:34,280 --> 00:19:37,620
+عندي dy by dx
+
+178
+00:19:43,030 --> 00:19:47,250
+small معناته اذا كان ال dy by dx مثلا point one
+
+179
+00:19:47,250 --> 00:19:50,790
+معناه ال dy by dx لكل تربيع هتكون point one تربيع
+
+180
+00:19:50,790 --> 00:19:58,030
+يعني هتكون very small معناه ال dy by dx لكل تربيع
+
+181
+00:19:58,030 --> 00:20:05,670
+هتكون very small معناه
+
+182
+00:20:05,670 --> 00:20:12,580
+ال term هذاإذا dy by dx بيكون صغير يعني الكلتر
+
+183
+00:20:12,580 --> 00:20:19,500
+بيكون صغير جدا في الحالة هذه الكلتر
+
+184
+00:20:19,500 --> 00:20:26,420
+بيها is very small compared
+
+185
+00:20:26,420 --> 00:20:30,680
+بالمقارنة مع الواحد في
+
+186
+00:20:30,680 --> 00:20:33,780
+الحالة
+
+187
+00:20:33,780 --> 00:20:51,780
+دوسريندي واحد على رويصير ساعة تقريبا D2 D2
+
+188
+00:20:51,780 --> 00:21:04,860
+Y by DX2 بالساعة من هنا M على E في I معناته هذا
+
+189
+00:21:04,860 --> 00:21:11,250
+أهم relationم علي اي بساو دي square y by دي اكس
+
+190
+00:21:11,250 --> 00:21:12,210
+square
+
+191
+00:21:38,530 --> 00:21:43,210
+أحنا من ال chapter تلاتة كنا نعرف ان ال V بيساوي
+
+192
+00:21:43,210 --> 00:21:57,370
+DM by DX يعني هتساوي و DM by DX و ال Q و
+
+193
+00:21:57,370 --> 00:21:58,430
+ال V بيساوي
+
+194
+00:22:04,050 --> 00:22:11,630
+و ال Q بيستوى DV by DX معناته based on this هيكون
+
+195
+00:22:11,630 --> 00:22:17,030
+ان ال V على EI بيستوى المشتقة التالتة ل Y بالنسبة
+
+196
+00:22:17,030 --> 00:22:22,170
+ل X و ال Q على EI بيستوى المشتقة الرابعة ل Y على
+
+197
+00:22:22,170 --> 00:22:28,850
+DX احنا بشكل أساسي بتجهيبنا العلاقة اللي هي M على
+
+198
+00:22:28,850 --> 00:22:48,450
+EIبساوي المشتقة التانية d²y by dx² هنحل
+
+199
+00:22:48,450 --> 00:22:52,170
+مثال نشوف كيف ممكن نحسب ال deflection و ال slopes
+
+200
+00:22:52,170 --> 00:22:58,690
+في straight beams باستخدام علاقة م على ei بساوي
+
+201
+00:22:58,690 --> 00:23:00,210
+d²y by dx
+
+202
+00:23:07,870 --> 00:23:12,610
+خلّيني أضعها جانب M
+
+203
+00:23:12,610 --> 00:23:30,050
+عند
+
+204
+00:23:30,050 --> 00:23:34,570
+مبين beam عليه
+
+205
+00:23:34,570 --> 00:23:43,750
+load موزع Wال W قيمتها تمانين pound force لكل انش
+
+206
+00:23:43,750 --> 00:23:50,450
+ال beam طوله عشرين انش ال beam is simply supported
+
+207
+00:23:50,450 --> 00:23:51,210
+at the end
+
+208
+00:24:04,310 --> 00:24:09,370
+using equation 412 م على اي او اي بيستوى دي square
+
+209
+00:24:09,370 --> 00:24:13,910
+واي بقى دي اكس square determine equations for
+
+210
+00:24:13,910 --> 00:24:18,590
+slope and deflection of the beam بدوا معادلات ال
+
+211
+00:24:18,590 --> 00:24:24,050
+slope و ال deflection لبيم عند اي نقطة و ال slope
+
+212
+00:24:24,050 --> 00:24:29,970
+at the ends ال slope عند الأطراف و ال maximum
+
+213
+00:24:29,970 --> 00:24:32,290
+deflection ال maximum deflection طبعا في الحالة
+
+214
+00:24:32,290 --> 00:24:33,370
+هتكون في النص
+
+215
+00:24:37,940 --> 00:24:42,180
+أولش طبعا هرسم free body diagram عشان اوش دي
+
+216
+00:24:42,180 --> 00:24:46,740
+reactions are واحد وال
+
+217
+00:24:46,740 --> 00:24:54,020
+reaction are اتنين هذا
+
+218
+00:24:54,020 --> 00:24:59,500
+ال load هيكون equivalent له load
+
+219
+00:24:59,500 --> 00:25:08,160
+اللي هيكون عشرين في تمانين يعني الف و ستمائتPound
+
+220
+00:25:08,160 --> 00:25:10,800
+و ال equivalent load جاي فى النص المعناه اللى
+
+221
+00:25:10,800 --> 00:25:15,180
+هتتوزع بالتساوى على الأطراف هكون الف ستمية على
+
+222
+00:25:15,180 --> 00:25:22,460
+ايه؟ على اتنين يعني هكون عندى هنا تمانمية تمانمية
+
+223
+00:25:22,460 --> 00:25:29,480
+pound وهنا R اتنين بالساوية تمانمية pound طبعا
+
+224
+00:25:29,480 --> 00:25:33,600
+هرسم ال .. ال .. ال shear diagram و ال money
+
+225
+00:25:33,600 --> 00:25:36,140
+diagram او بدي اخد هذا ال X
+
+226
+00:25:39,030 --> 00:25:49,390
+و هذا ال Y بتاخد على مسافة X بتاخد
+
+227
+00:25:49,390 --> 00:25:55,530
+جزء من ال beam على مسافة X فين
+
+228
+00:25:55,530 --> 00:26:04,470
+دي هنا كانت force اللي هي 800 pound هذه
+
+229
+00:26:04,470 --> 00:26:05,450
+المسافة X
+
+230
+00:26:11,380 --> 00:26:19,960
+طبعا هكون في عندي shear force V و في عندي bending
+
+231
+00:26:19,960 --> 00:26:28,820
+moment M و
+
+232
+00:26:28,820 --> 00:26:35,020
+هاي ال Y direction و هاي ال X direction
+
+233
+00:26:42,800 --> 00:26:49,640
+طبعا في عندى كمان distributed load
+
+234
+00:26:49,640 --> 00:26:58,260
+لو
+
+235
+00:26:58,260 --> 00:27:03,920
+أخد summation of forces باتجاه ال Y بالساوة سفر
+
+236
+00:27:03,920 --> 00:27:07,180
+هيكون عندى
+
+237
+00:27:12,760 --> 00:27:23,940
+الأعلى عندي 800 ناقص عندي هذه 80 ناقص 80 في X لتحت
+
+238
+00:27:23,940 --> 00:27:31,920
+ناقص 80 في X لتحت minus
+
+239
+00:27:31,920 --> 00:27:38,600
+V بساوي 0 معناته
+
+240
+00:27:38,600 --> 00:27:38,980
+ال V
+
+241
+00:27:45,160 --> 00:27:56,740
+حتساوي تمانين اكس نقص تمانمية او V بستاوي العكس ال
+
+242
+00:27:56,740 --> 00:28:02,240
+V بستاوي التمانمية minus
+
+243
+00:28:02,240 --> 00:28:08,080
+تمانين اكس هذا ال V
+
+244
+00:28:13,100 --> 00:28:23,280
+احنا سابقا حكينا ال V بيساوي DM by DX ال V بيساوي
+
+245
+00:28:23,280 --> 00:28:39,400
+DM by DX معناه DM بيساوي V DX يعني هيساوي ال V
+
+246
+00:28:39,400 --> 00:28:42,620
+اللي هي 800 minus 80 X
+
+247
+00:28:45,620 --> 00:28:51,620
+DX و هنا DM هنا هعمل تكامل ال M عند الطرف كانت سفر
+
+248
+00:28:51,620 --> 00:28:59,880
+to M و هنا عندي التكامل
+
+249
+00:28:59,880 --> 00:29:07,480
+من سفر ل X يعني انا هتكون عند ال M بتساوي
+
+250
+00:29:07,480 --> 00:29:12,000
+تبنيات
+
+251
+00:29:12,000 --> 00:29:13,340
+X
+
+252
+00:29:15,610 --> 00:29:28,190
+ناقص اربعين اكس تربيع هداش ال moment لحظة
+
+253
+00:29:28,190 --> 00:29:33,290
+هو ماعطينا العلاقة هان M بالساوية W ال على اتنين
+
+254
+00:29:33,290 --> 00:29:40,090
+في اكس W تمانين تمانين و ال اكم عشرين تمانين في
+
+255
+00:29:40,090 --> 00:29:43,570
+عشرين الف ست مية على اتنين تمان مية هاي هطلع تانية
+
+256
+00:29:43,570 --> 00:29:47,760
+تمان ميةعندها و على اتنين و تمانين تمانين على
+
+257
+00:29:47,760 --> 00:29:58,780
+اتنين اربعين المناورة للعلاقات and if صحيحة لان
+
+258
+00:29:58,780 --> 00:30:05,120
+عشان اواجه ال deflection انا
+
+259
+00:30:05,120 --> 00:30:14,040
+في عند relation في علاقة بين ال M على EI بتساوي
+
+260
+00:30:16,640 --> 00:30:25,580
+الـ d² y على dx تربيع يعني
+
+261
+00:30:25,580 --> 00:30:40,920
+احاسس ان الـ d by dx ل dy by dx بتساوي عوض 1 على e
+
+262
+00:30:40,920 --> 00:30:41,540
+في i
+
+263
+00:30:45,950 --> 00:30:52,530
+الـ M اللي هي تمنمية تمنمية
+
+264
+00:30:52,530 --> 00:31:08,310
+X مينوس أربعين X تربيع بعمل
+
+265
+00:31:08,310 --> 00:31:12,970
+تكامل لهذه حسيب عندي D
+
+266
+00:31:16,280 --> 00:31:29,760
+الى dy by dx بتساوي 1 على ei في 800x minus 40x
+
+267
+00:31:29,760 --> 00:31:36,540
+تربيع dx وبعمل تكامل للطرفين
+
+268
+00:31:45,370 --> 00:32:02,030
+حسينا الـ dy by dx بتساوي 1 على ei في مشتقة 800x
+
+269
+00:32:02,030 --> 00:32:10,370
+عبارة عن 400x تربيع ناقص
+
+270
+00:32:10,370 --> 00:32:13,990
+40 ع
+
+271
+00:32:13,990 --> 00:32:20,730
+3x تكييب زائد constant واحد constant of
+
+272
+00:32:20,730 --> 00:32:24,710
+integration بعمل
+
+273
+00:32:24,710 --> 00:32:33,150
+integration كمان مرة integrate هصير
+
+274
+00:32:33,150 --> 00:32:40,630
+عندي ال y بالساوية واحد على ei
+
+275
+00:32:43,270 --> 00:33:00,690
+في 400 على 3 x تكيب ناقص 400 على 3 في 4 على 12 x
+
+276
+00:33:00,690 --> 00:33:07,650
+أص 4 زائد c1 في x زائد c2
+
+277
+00:33:11,860 --> 00:33:17,960
+لأن I have to find ال C1 and C2 using the boundary
+
+278
+00:33:17,960 --> 00:33:23,420
+or end conditions find C1
+
+279
+00:33:23,420 --> 00:33:33,240
+and C2 using the boundary conditions
+
+280
+00:33:33,240 --> 00:33:36,940
+عند
+
+281
+00:33:36,940 --> 00:33:40,420
+أنا بعرف deflection يعني عندي why
+
+282
+00:33:42,160 --> 00:33:50,620
+بتساوي Zero at X بتساوي Zero يعني لو حطيت هنا Zero
+
+283
+00:33:50,620 --> 00:33:59,580
+هكون واحد على EI طبعا في Zero ناقص Zero زائد C
+
+284
+00:33:59,580 --> 00:34:05,480
+واحد في Zero زائد C اتنين معناته C اتنين تطلع
+
+285
+00:34:05,480 --> 00:34:10,480
+تساوي ايش صفر و برضه عند ال End التاني مافيش
+
+286
+00:34:10,480 --> 00:34:19,070
+Deflectiony equals zero at
+
+287
+00:34:19,070 --> 00:34:25,870
+x بالساوية عشرين المعنى انت حاسيه ان اعوض هنا
+
+288
+00:34:25,870 --> 00:34:34,170
+حاسيه ان عندي ال zero بتساوي واحد على ei في
+
+289
+00:34:34,170 --> 00:34:47,760
+اربعمية ع تلاتة في عشرين تكييب-400 على 12 في 20
+
+290
+00:34:47,760 --> 00:34:52,340
+أقصى 4 زائد
+
+291
+00:34:52,340 --> 00:35:02,240
+C1 في 20 يعني
+
+292
+00:35:02,240 --> 00:35:05,080
+إذا قسمت الطرفين على 20 هسينا اندي C1
+
+293
+00:35:07,550 --> 00:35:20,170
+هتكون تساوي واحد على EI فيه
+
+294
+00:35:20,170 --> 00:35:31,010
+اربعمية ع اتناش يعني مية ع تلاتة فعشرين تكييب ناقص
+
+295
+00:35:31,010 --> 00:35:35,270
+اربعمية
+
+296
+00:35:37,300 --> 00:35:41,540
+ع تلاتة في
+
+297
+00:35:41,540 --> 00:35:45,740
+عشرين تربيع
+
+298
+00:35:45,740 --> 00:35:49,340
+يعني
+
+299
+00:35:49,340 --> 00:35:57,620
+إذا خدتها على مشترك عشرين تربيع في مية يعني أخدت
+
+300
+00:35:57,620 --> 00:36:06,620
+تلاتة برا و أخدت عشرين تربيع اللي هي أربعة مية مية
+
+301
+00:36:08,470 --> 00:36:14,390
+في عشرين تربيع بتصفى
+
+302
+00:36:14,390 --> 00:36:17,730
+مية
+
+303
+00:36:17,730 --> 00:36:24,850
+ع تلاتة بتروح وعشرين تربيع بتصفى عندهين عشرين ناقص
+
+304
+00:36:24,850 --> 00:36:29,290
+حد
+
+305
+00:36:29,290 --> 00:36:31,270
+على مية ناقص أربعة
+
+306
+00:36:37,490 --> 00:36:46,350
+يعني انا هتكون اربعة
+
+307
+00:36:46,350 --> 00:36:54,130
+عندين اتنين اتنين اربعة واحد اتنين تلاتة اربعة
+
+308
+00:36:54,130 --> 00:37:02,250
+أسفار في ستاش ع تلاتة في EI
+
+309
+00:37:08,440 --> 00:37:11,200
+معناته هتصير المعادل بتاع الـ deflection الـ Y
+
+310
+00:37:11,200 --> 00:37:14,840
+هتساوي
+
+311
+00:37:14,840 --> 00:37:18,760
+1
+
+312
+00:37:18,760 --> 00:37:34,200
+على EI في 400 ع 3 X سكيب ناقص 400 ع 12 X أس 4
+
+313
+00:37:36,620 --> 00:37:43,620
+أربعمية اربعمية اربعين أربعين الف في ستاش ع تلاتة
+
+314
+00:37:43,620 --> 00:37:49,180
+EI في X هذه
+
+315
+00:37:49,180 --> 00:37:57,860
+معادلة ال deflection ال slope هيكون DY by DX
+
+316
+00:38:06,040 --> 00:38:13,840
+هيكون واحد على EI فيه
+
+317
+00:38:13,840 --> 00:38:26,440
+أربعمية X تربية ناقص أربعمية على تلاتة هذه X تربية
+
+318
+00:38:26,440 --> 00:38:33,380
+هذه X تكيب زائد
+
+319
+00:38:33,380 --> 00:38:46,040
+أربعميةفى 16 ع 3EI طبعا
+
+320
+00:38:46,040 --> 00:38:51,460
+المعادلة هذه بتعطى deflection anywhere and at any
+
+321
+00:38:51,460 --> 00:38:57,600
+x و المعادلة التانية بتعطى slope
+
+322
+00:39:06,320 --> 00:39:13,180
+الـ male at any x الان
+
+323
+00:39:13,180 --> 00:39:16,820
+بد هو الـ deflection at the ends يعني بد الـ
+
+324
+00:39:16,820 --> 00:39:22,100
+deflection at x equal zero و الـ deflection at x
+
+325
+00:39:22,100 --> 00:39:24,840
+يساوي L اللي هي عشرين at
+
+326
+00:39:33,790 --> 00:39:44,010
+x equals 0 هيكون y dy ال slope dy
+
+327
+00:39:44,010 --> 00:39:50,530
+by dx هتساوي .. هنعوض هنا عن x الساوية zero سفر
+
+328
+00:39:50,530 --> 00:40:00,030
+سفر هتكون أربعمية في ستاش على E في I طبعا E بنعوض
+
+329
+00:40:00,030 --> 00:40:07,790
+عنا I بنعوض على هذهعند X بالساوية سفر و DY by DX
+
+330
+00:40:07,790 --> 00:40:17,630
+عند X بالساوية عشرين هتساوية عموضين واحد
+
+331
+00:40:17,630 --> 00:40:30,520
+على EI في أربعمية في عشرين تربيع ناقص أربعميةفي
+
+332
+00:40:30,520 --> 00:40:42,100
+عشرين تكييب على تلاتة زائد أربعمية في ستاش على
+
+333
+00:40:42,100 --> 00:40:51,440
+تلاتة EI و بنحسبها ال maximum deflection one هيكون
+
+334
+00:40:51,440 --> 00:40:59,720
+في النص هذا ال maximum deflection
+
+335
+00:41:03,310 --> 00:41:11,690
+deflection is maximum
+
+336
+00:41:11,690 --> 00:41:19,650
+at x بالساوية L على 2 اللي هي بالساوية عشرة يعني
+
+337
+00:41:19,650 --> 00:41:25,030
+هتكون y maximum بتساوي
+
+338
+00:41:25,030 --> 00:41:28,430
+واحد
+
+339
+00:41:28,430 --> 00:41:41,040
+على EIفي اربعمية على تلاتة في عشرة تكييب ناقص
+
+340
+00:41:41,040 --> 00:41:50,660
+اربعمية على اتناش في عشرة اقص اربعة زائد
+
+341
+00:42:01,440 --> 00:42:06,140
+هذه في صفرين على فكرة هنا زائد
+
+342
+00:42:06,140 --> 00:42:09,340
+اربعين
+
+343
+00:42:09,340 --> 00:42:19,140
+الف في ستاشع ع تلاتة EI في عشرة و بنحسب القيامة
+
+344
+00:42:19,140 --> 00:42:25,360
+بتوقع انكوا تحسبوا الأرقام و تطلعوا أرقام حقيقية
+
+345
+00:42:49,680 --> 00:42:51,080
+مش عارف كده
+
+346
+00:43:06,670 --> 00:43:10,310
+الان في اكتر من طريقة لحساب الـ deflections في ال
+
+347
+00:43:10,310 --> 00:43:13,810
+.. في ال beams فى عندنا superposition method فى
+
+348
+00:43:13,810 --> 00:43:16,510
+عند ال moment area method عند numerical
+
+349
+00:43:16,510 --> 00:43:20,210
+integration عندنا Castellano method وعندنا ال
+
+350
+00:43:20,210 --> 00:43:26,330
+finite element method هنبدأ في ال .. ال beam
+
+351
+00:43:26,330 --> 00:43:30,230
+deflection by superposition ال beam deflection by
+
+352
+00:43:30,230 --> 00:43:33,970
+superposition تعتمد إذا أنا كان beam عليه loading
+
+353
+00:43:35,070 --> 00:43:39,690
+معين متنوع ممكن اجزء ال effect يعني ال total
+
+354
+00:43:39,690 --> 00:43:44,250
+effect عبارة عن مجموع individual effects و بستخدم
+
+355
+00:43:44,250 --> 00:43:47,870
+اللي هي ال beef deflection formulas من ال appendix
+
+356
+00:43:47,870 --> 00:43:55,030
+A9 اذا بنفتح الكتاب على ال appendix
+
+357
+00:43:55,030 --> 00:44:00,570
+A9
+
+358
+00:44:04,060 --> 00:44:11,480
+نفتح ال appendix هنشوف
+
+359
+00:44:11,480 --> 00:44:19,100
+في عندى beams مختلفة مثلا عندى هين كانت river beam
+
+360
+00:44:19,100 --> 00:44:23,960
+عليه بيأثر ال load ومعطيني ال reaction و ال moment
+
+361
+00:44:23,960 --> 00:44:31,070
+ومعطيني ال .. ال ..الشير at any location ومعطيني
+
+362
+00:44:31,070 --> 00:44:34,750
+ال moment at any location ومعطيني ال deflection و
+
+363
+00:44:34,750 --> 00:44:38,370
+ال maximum deflection طبعا عندى مجموعة من ال beams
+
+364
+00:44:38,370 --> 00:44:46,070
+المختلفة هذا ال table A9 يعني عندى طرق مختلفة
+
+365
+00:44:46,070 --> 00:44:47,350
+للتحميل ال beams
+
+366
+00:44:55,260 --> 00:45:00,240
+عندي حوالي عشر حالات، اتناشر حالة، تلاتاش،
+
+367
+00:45:00,240 --> 00:45:08,040
+اربعتاش، خمستاش، ستاش، حوالي ستاشر حالة تحميل
+
+368
+00:45:08,040 --> 00:45:12,120
+مختلفة، حوالي ستاشر حالة تحميل مختلفة
+
+369
+00:45:25,430 --> 00:45:30,190
+إذا بدك تفاصيل أكتر بتروح المرجع هذا rocks
+
+370
+00:45:30,190 --> 00:45:33,750
+formulas for stress and strain هتشوف حالات و
+
+371
+00:45:33,750 --> 00:45:37,430
+تفاصيل .. يعني هتشوف شغلات أكتر من اللي عرضنا في
+
+372
+00:45:37,430 --> 00:45:43,710
+ال appendix A9 لإن
+
+373
+00:45:43,710 --> 00:45:51,930
+هنشوف كيف نحلحسابات الـ deflection باستخدام اللي
+
+374
+00:45:51,930 --> 00:45:57,270
+هو ال superposition واستخدام الجداول نطلع على
+
+375
+00:45:57,270 --> 00:46:01,250
+المثال الحالي consider the uniformly loaded beam
+
+376
+00:46:01,250 --> 00:46:05,670
+with a concentrated force as shown في عند ال beam
+
+377
+00:46:05,670 --> 00:46:13,600
+فيه بأثر عليه حمل مركز F على بعد Aو فيه برضه بيأثر
+
+378
+00:46:13,600 --> 00:46:20,500
+عليه حمل موزع قيمته W ال beam طوله L ال beam is
+
+379
+00:46:20,500 --> 00:46:27,960
+simply supported عند نقطة A عند نقطة C using
+
+380
+00:46:27,960 --> 00:46:31,700
+superposition determine the reactions and
+
+381
+00:46:31,700 --> 00:46:35,100
+deflections as a function of X باستخدام ال
+
+382
+00:46:35,100 --> 00:46:40,940
+superposition أوجد ال deflectionsو ال slopes و ال
+
+383
+00:46:40,940 --> 00:46:43,980
+reactions as a function of x هذه المسألة مركبة
+
+384
+00:46:43,980 --> 00:46:59,940
+يعني عشان أحلها بدي أعتبر أنا عندي P F
+
+385
+00:46:59,940 --> 00:47:07,940
+و عندي هنا R1 و أنا عندي R2
+
+386
+00:47:09,430 --> 00:47:21,410
+و في كمان distributed load
+
+387
+00:47:21,410 --> 00:47:26,650
+هذا يمكن ان يعتبر عبارة كأنه two beams one beam
+
+388
+00:47:39,690 --> 00:47:50,530
+R1' R2' R2'
+
+389
+00:47:50,550 --> 00:48:03,290
+R2' R2' R2' R2' R2' R2' R2' R2'
+
+390
+00:48:06,210 --> 00:48:11,850
+R2W' هذه هي ال beam الأساسي عليه concentrated load
+
+391
+00:48:11,850 --> 00:48:15,870
+at this point F ويعني distributed load all over
+
+392
+00:48:15,870 --> 00:48:21,370
+the beam هذي يكون اعتبره كأنه عبارة عن مجموع and
+
+393
+00:48:21,370 --> 00:48:25,710
+it is مجموع two beams one beam has a concentrated
+
+394
+00:48:25,710 --> 00:48:30,670
+load F another beam has a distributed load W
+
+395
+00:48:33,520 --> 00:48:43,300
+الان انا هرجع و ال total reaction R1 بيكون سوى R1
+
+396
+00:48:43,300 --> 00:48:55,100
+prime زاد R1 double prime و R2 بيكون سوى R2 prime
+
+397
+00:48:55,100 --> 00:48:57,860
+زاد R2 double prime
+
+398
+00:49:11,920 --> 00:49:21,060
+الحالة الأولى هرجع لبندق ال four هذه نحكي هنا
+
+399
+00:49:21,060 --> 00:49:25,120
+refer to
+
+400
+00:49:25,120 --> 00:49:34,540
+appendix aتسعة ستة هاي A تسعة ستة عبارة هتبثل بيم
+
+401
+00:49:34,540 --> 00:49:40,760
+تحت أثير حمل المركز على بعد A وطول ال beam L
+
+402
+00:49:40,760 --> 00:49:49,020
+معطيني R واحد برايم بتساوي
+
+403
+00:49:49,020 --> 00:49:52,060
+FB على L
+
+404
+00:50:01,870 --> 00:50:13,930
+R2' FA على L مُعطين
+
+405
+00:50:13,930 --> 00:50:21,390
+الـ Deflection YAB
+
+406
+00:50:36,830 --> 00:50:49,950
+YAB' أو يسميها Y prime هتكون
+
+407
+00:50:49,950 --> 00:51:01,490
+عبارة عن جزءينهذا الجزء اللي هو FBX على
+
+408
+00:51:01,490 --> 00:51:17,050
+ستة EIL في X تربيع زائد B تربيع مانقس L تربيع طبعا
+
+409
+00:51:17,050 --> 00:51:29,820
+هذا X بين A و BX أكبر أو يساوي سفر وأقل من B و
+
+410
+00:51:29,820 --> 00:51:37,720
+بتساوي من B ل C FA في
+
+411
+00:51:37,720 --> 00:51:48,360
+L minus X على 6EIL في
+
+412
+00:51:48,360 --> 00:51:49,220
+X تربيع
+
+413
+00:51:51,610 --> 00:52:01,630
+زاد a تربيع ماقص 2LX طبعا
+
+414
+00:52:01,630 --> 00:52:10,310
+X أكبر أو يساوي هنا أكبر أو يساوي A
+
+415
+00:52:10,310 --> 00:52:15,690
+وأصغر من L
+
+416
+00:52:23,340 --> 00:52:29,960
+هذه المعادلات كلها
+
+417
+00:52:29,960 --> 00:52:37,080
+هي four concentrated load
+
+418
+00:52:37,080 --> 00:52:51,420
+اللي هو appendix A96 هذه الحالة التانية
+
+419
+00:52:51,420 --> 00:52:52,080
+اللي هي هذه
+
+420
+00:52:54,810 --> 00:53:03,690
+هنشوفها في أبندكس A97 هيكون
+
+421
+00:53:03,690 --> 00:53:08,270
+عندي R1 double prime R1
+
+422
+00:53:08,270 --> 00:53:16,270
+double prime بيستوى
+
+423
+00:53:16,270 --> 00:53:25,990
+WL على 2 بيستوى R2Double prime بيساوي WL على اتنين
+
+424
+00:53:25,990 --> 00:53:29,830
+وDeflection
+
+425
+00:53:29,830 --> 00:53:36,890
+Y بتساوي
+
+426
+00:53:36,890 --> 00:53:46,710
+WX على 24WX على 24EI
+
+427
+00:53:49,770 --> 00:53:55,350
+في 2LX تربية minus
+
+428
+00:53:55,350 --> 00:53:59,590
+X تكييب minus
+
+429
+00:53:59,590 --> 00:54:04,970
+L تكييب هذا
+
+430
+00:54:04,970 --> 00:54:12,950
+Y double prime الآن ال total effect ال total
+
+431
+00:54:12,950 --> 00:54:13,550
+effect
+
+432
+00:54:23,990 --> 00:54:32,490
+هيكون عندى ال R1 R1 prime زاد R1 double prime يعني
+
+433
+00:54:32,490 --> 00:54:36,490
+هيكون الساوية R1
+
+434
+00:54:36,490 --> 00:54:48,970
+prime اللي هي FB على L وR1 double prime زاد WL على
+
+435
+00:54:48,970 --> 00:54:57,060
+2 هذا ال total reaction و ال R2يستوى R2 prime زي
+
+436
+00:54:57,060 --> 00:55:07,300
+R2 double prime يعني هتكون FA على L زي
+
+437
+00:55:07,300 --> 00:55:15,440
+WL على 2 هذا لل reactions بالنسبة لل deflection ال
+
+438
+00:55:15,440 --> 00:55:21,060
+Y هتكون تستوى Y prime
+
+439
+00:55:23,850 --> 00:55:37,630
+زائد y double prime يعني ال y هتكون تساوي ال
+
+440
+00:55:37,630 --> 00:55:49,590
+y y prime هتكون
+
+441
+00:55:49,590 --> 00:55:51,090
+تساوي fbx
+
+442
+00:55:55,690 --> 00:56:07,090
+على ستة EI L في X تربية زائد B تربية minus L تربية
+
+443
+00:56:07,090 --> 00:56:25,050
+زائد WX على أربع و عشرين EI في اتنين L X تربية- X
+
+444
+00:56:25,050 --> 00:56:38,550
+تكييب- L تكييب هذا في حالة X بين Zero و A بين
+
+445
+00:56:38,550 --> 00:56:52,690
+B و C هتكون FA FA في L-X على 6EI
+
+446
+00:56:54,220 --> 00:57:06,760
+L في X تربيع زاد A تربيع ناقص 2LX زاد
+
+447
+00:57:06,760 --> 00:57:10,760
+WX
+
+448
+00:57:10,760 --> 00:57:23,590
+على 24EI في 2LX تربيعminus X تكييب minus L تكييب
+
+449
+00:57:23,590 --> 00:57:31,670
+هذا طبعا X بين B و C أكبر من A و أصغر من L هذا هو
+
+450
+00:57:31,670 --> 00:57:38,530
+ال total deflection
+
+451
+00:57:38,530 --> 00:57:43,910
+معناته
+
+452
+00:57:43,910 --> 00:57:48,210
+باستخدام ال source position جزأت المثلة هذا ال
+
+453
+00:57:48,210 --> 00:57:53,250
+total loadingعبارة عن مجموع two loading conditions
+
+454
+00:57:53,250 --> 00:57:56,170
+ال loading condition الأولى هي عبارة عن
+
+455
+00:57:56,170 --> 00:57:59,950
+concentrated load at point B و ال another loading
+
+456
+00:57:59,950 --> 00:58:02,630
+condition عبارة عن distributed load all over the
+
+457
+00:58:02,630 --> 00:58:10,050
+beam المحاضرة
+
+458
+00:58:10,050 --> 00:58:13,110
+الجاي بنكمل
+
diff --git a/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/EruFwa8nhZA_postprocess.srt b/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/EruFwa8nhZA_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..0eb7fd02565c5d840d584f248d00f7dc22d045e9
--- /dev/null
+++ b/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/EruFwa8nhZA_postprocess.srt
@@ -0,0 +1,2924 @@
+1
+00:00:04,880 --> 00:00:07,420
+بسم الله الرحمن الرحيم السلام عليكم و رحمة الله
+
+2
+00:00:07,420 --> 00:00:12,620
+اليوم هنكمل اللي هو fatigue failure due to dynamic
+
+3
+00:00:12,620 --> 00:00:16,240
+loading في المحاضرات السابقة حكينا عن fatigue
+
+4
+00:00:16,240 --> 00:00:22,280
+criteria for ductile materials اتعرفنا على ال S
+
+5
+00:00:22,280 --> 00:00:28,080
+-endogram ال S-endogram فرضنا او حددنا مناطق
+
+6
+00:00:28,080 --> 00:00:32,930
+finite life و infinite lifeكان في علاقة بين ال
+
+7
+00:00:32,930 --> 00:00:36,530
+endurance limit وال tensile strength بشكل عام ال
+
+8
+00:00:36,530 --> 00:00:41,870
+SE prime بصفر نص ال SUT في
+
+9
+00:00:41,870 --> 00:00:45,270
+حالة ال finite life جيبنا معدلات في حالة كانت
+
+10
+00:00:45,270 --> 00:00:50,170
+العمر ال ال part من واحد لألف cycle جيبنا equation
+
+11
+00:00:50,640 --> 00:00:53,680
+و جيبنا equation في حالة كانت ال life من الف
+
+12
+00:00:53,680 --> 00:00:59,500
+لمليون cycle و بعدين بدنا ندرس في ال infinite ..
+
+13
+00:00:59,500 --> 00:01:03,060
+في ال design .. fatigue design for infinite life
+
+14
+00:01:03,060 --> 00:01:07,580
+في الحالة دي كان يلزمنا نعمل تعديلات على ال .. او
+
+15
+00:01:07,580 --> 00:01:11,940
+تعديلات على ال endurance limit لان ال endurance
+
+16
+00:01:11,940 --> 00:01:15,560
+limit لما تم قياسة .. اقتم قياسة لعينة معيارية
+
+17
+00:01:15,560 --> 00:01:19,520
+بمواصفات شكل او مقطع هندس معين و في surface finish
+
+18
+00:01:19,520 --> 00:01:23,850
+معينزاد ال loading كان completely reversed pending
+
+19
+00:01:23,850 --> 00:01:27,310
+لكن على الأرض الواقع بيكونش نفس ال surface finish
+
+20
+00:01:27,310 --> 00:01:30,570
+بيكونش نفس ال .. ال .. ال .. الكتر ال loading
+
+21
+00:01:30,570 --> 00:01:36,030
+مختلف القطعة ممكن تكون مدورة ممكن تكون مدورة مش
+
+22
+00:01:36,030 --> 00:01:40,450
+مدورة درجة الحرارة reliability كل هذه العوامل لازم
+
+23
+00:01:40,450 --> 00:01:43,150
+نعملها modification factor عشان هيك حكينا SE
+
+24
+00:01:43,150 --> 00:01:48,730
+بالساوية K A K B K C K D K A K F في SE prime
+
+25
+00:01:53,010 --> 00:01:56,690
+بعدين أخدنا الحالة اللى بتكون عندى اللى هو ال
+
+26
+00:01:56,690 --> 00:02:03,010
+general fluctuating case حسبنا ال alternating
+
+27
+00:02:03,010 --> 00:02:07,310
+stress و ال mean stress و بعدين we apply design
+
+28
+00:02:07,310 --> 00:02:10,290
+theory اللى هي modified Godman theory و الgerber
+
+29
+00:02:10,290 --> 00:02:13,190
+theory و ال asthma elliptic و Stoderberg for
+
+30
+00:02:13,190 --> 00:02:17,770
+fatigue design for yielding we apply اللى هو ال
+
+31
+00:02:17,770 --> 00:02:24,140
+Langer lineبعدين أخدنا حالة أكثر عمومية أنه ال
+
+32
+00:02:24,140 --> 00:02:26,840
+loading ممكن يكون multiple loading conditions ممكن
+
+33
+00:02:26,840 --> 00:02:30,020
+يكون عندك axial loading مع torsion مع .. مع
+
+34
+00:02:30,020 --> 00:02:35,960
+bending في الحالة هذه بنحسب .. حسبنا alternating
+
+35
+00:02:35,960 --> 00:02:40,940
+volumizes stress و mid range volumizes stress
+
+36
+00:02:40,940 --> 00:02:43,720
+بعدين أخدنا ال .. ال .. ال هو sigma a prime و
+
+37
+00:02:43,720 --> 00:02:46,560
+sigma m prime و ي apply ال design theories اللي
+
+38
+00:02:46,560 --> 00:02:49,240
+ذكرناها السابقين اللي هم ال good .. المدفعة
+
+39
+00:02:49,240 --> 00:02:52,430
+goodmanوالجيربر و الازميل الليبتيك والسودربيرج
+
+40
+00:02:52,430 --> 00:02:57,670
+حللنا مجموعة من الأمثلة for ductile materials
+
+41
+00:02:57,670 --> 00:03:01,050
+اليوم هنكمل في الفتيه criteria for brittle
+
+42
+00:03:01,050 --> 00:03:07,590
+materials في حالة ال brittle materials احنا عشان
+
+43
+00:03:07,590 --> 00:03:15,090
+نعمل design criteria كان يكون لنا curve هنا عندى
+
+44
+00:03:15,090 --> 00:03:21,580
+ال sigma Mع ال x axis و ال sigma alternating على
+
+45
+00:03:21,580 --> 00:03:30,700
+ال y axis في حالة brittle materials ال design
+
+46
+00:03:30,700 --> 00:03:36,060
+theory it will depend on
+
+47
+00:03:36,060 --> 00:03:36,640
+two curves
+
+48
+00:03:49,330 --> 00:03:51,690
+إذا كان الـ sigma alternating و ال sigma mean
+
+49
+00:03:51,690 --> 00:03:56,350
+موجبين هنكون في ال first quadrant إذا كانت ال
+
+50
+00:03:56,350 --> 00:03:59,150
+sigma mean negative و ال sigma alternating ال
+
+51
+00:03:59,150 --> 00:04:02,310
+sigma alternating دايما موجبة ال sigma mean ممكن
+
+52
+00:04:02,310 --> 00:04:05,790
+تكون موجبة أو سلبة إذا كانت ال sigma mean سلبة
+
+53
+00:04:05,790 --> 00:04:08,970
+يعني هنكون في الرابع التاني في حال تكون في الرابع
+
+54
+00:04:08,970 --> 00:04:16,690
+الأول في design criteria هنا عندي sut وهنا عندي se
+
+55
+00:04:19,180 --> 00:04:24,100
+في حال كنا في ال first quadrant ال fatigue في ال
+
+56
+00:04:24,100 --> 00:04:27,900
+criteria follows concave upward concave upward
+
+57
+00:04:27,900 --> 00:04:33,440
+smith dallon equation اللي هي given by this
+
+58
+00:04:33,440 --> 00:04:38,120
+equation S المعادلة هذه لأن هذا concave up curve
+
+59
+00:04:38,120 --> 00:04:44,910
+جاء بين ال S U T و ال S E ال S A في الحالة هذهS A
+
+60
+00:04:44,910 --> 00:04:57,470
+على S E بالساوية واحد minus S M على S U T على واحد
+
+61
+00:04:57,470 --> 00:05:03,450
+زائد S M على S U T طبعا هذا ال loading line بتاعنا
+
+62
+00:05:03,450 --> 00:05:15,600
+هذا ال load line ان هي اللي هتكون ال sigma Mو الـ
+
+63
+00:05:15,600 --> 00:05:26,160
+Sigma alternating هذه SM وهذه S alternating طبعا
+
+64
+00:05:26,160 --> 00:05:29,160
+هذه المعادلة في حالة احنا كنا واقعين على ال filler
+
+65
+00:05:29,160 --> 00:05:35,720
+line لكن لو حطينا factor of safety حصير عنده هذه
+
+66
+00:05:35,720 --> 00:05:44,900
+حصير N Sigma Aعلى SE بيصيح واحد minus N Sigma M
+
+67
+00:05:44,900 --> 00:05:55,180
+على SUT على واحد زاد N Sigma M على SUT هذا في ال
+
+68
+00:05:55,180 --> 00:06:00,300
+first quadrant في ال second quadrant او خلينا نجد
+
+69
+00:06:00,300 --> 00:06:04,960
+نقطة التقاطع هذه لأن نقطة التقاطع اللي هي خط ال
+
+70
+00:06:04,960 --> 00:06:09,040
+loading lineمع ال failure line اللي هي تُعطى
+
+71
+00:06:09,040 --> 00:06:19,320
+بيحدثية SM و SA و ال slope لل load line R لسه و SA
+
+72
+00:06:19,320 --> 00:06:26,780
+على SM بتكون
+
+73
+00:06:26,780 --> 00:06:34,430
+الالـ S A اللي هي هذه تعتبر علاقة S A بسوا R S U T
+
+74
+00:06:34,430 --> 00:06:38,390
+زاد S E على 2 في minus 1 زاد الجزر التربيعي ل 1
+
+75
+00:06:38,390 --> 00:06:43,850
+زاد 4R S U T S E على R S U T زاد S E لكل تربيع
+
+76
+00:06:43,850 --> 00:06:48,670
+والـ R راح ينحكينا بسوا S A على S M هذا طبعا في ال
+
+77
+00:06:48,670 --> 00:06:52,570
+first quadrant في ال second quadrant ال fair
+
+78
+00:06:52,570 --> 00:06:56,890
+criteria is described by a linear by a line هذا ال
+
+79
+00:06:56,890 --> 00:07:07,480
+lineline ال slope بتاع الخط هذا slope of
+
+80
+00:07:07,480 --> 00:07:14,700
+the failure line بيساوي
+
+81
+00:07:14,700 --> 00:07:19,400
+ال slope of
+
+82
+00:07:19,400 --> 00:07:29,150
+failure line of failure curve and firstquadrant
+
+83
+00:07:29,150 --> 00:07:33,310
+عند
+
+84
+00:07:33,310 --> 00:07:42,810
+النقطة اللي هي zero و SE يعني عند النقطة هذه لأن
+
+85
+00:07:42,810 --> 00:07:50,130
+based on this principle هتكون عندى معادلة اللي هي
+
+86
+00:07:50,130 --> 00:07:51,330
+second line
+
+87
+00:07:59,540 --> 00:08:11,820
+اللي هي SA هتكون تساوي SE زائد SE minus
+
+88
+00:08:11,820 --> 00:08:20,740
+SE على S UT minus واحد طبعا ال load line هذا ال
+
+89
+00:08:20,740 --> 00:08:24,640
+load line تاني هذا ال load line
+
+90
+00:08:29,270 --> 00:08:35,770
+هذا النقطة هتكون SM وهذا SA
+
+91
+00:08:54,500 --> 00:08:57,360
+طب في ال first quadrant ال sigma alternating و
+
+92
+00:08:57,360 --> 00:08:59,720
+sigma mean both positive في ال second quadrant
+
+93
+00:08:59,720 --> 00:09:04,300
+sigma a is positive و sigma m is negative لأن
+
+94
+00:09:04,300 --> 00:09:10,560
+table A24 في الكتاب بيعطينا الخواص الميكانيكية لل
+
+95
+00:09:10,560 --> 00:09:14,460
+grey cast iron من ضمن الخواص اللي هي ال endurance
+
+96
+00:09:14,460 --> 00:09:21,600
+limit إذا بنروح على table A24 اللي
+
+97
+00:09:21,600 --> 00:09:22,100
+هو هذا
+
+98
+00:09:28,500 --> 00:09:32,140
+معطين different grades of grade cast iron اللي هو
+
+99
+00:09:32,140 --> 00:09:35,440
+cast iron عشرين، خمسة عشرين، تلاتين، خمس تلاتين،
+
+100
+00:09:35,440 --> 00:09:39,860
+اربعين، خمسين، ستين ومعطين ال tensile strength و
+
+101
+00:09:39,860 --> 00:09:43,320
+ال compressive strength ال SUC و ال shear modulus
+
+102
+00:09:43,320 --> 00:09:51,260
+ال S .. S .. rupture SSU و ال modulus of
+
+103
+00:09:51,260 --> 00:09:55,380
+elasticity in tension و in torsion و ال endurance
+
+104
+00:09:55,380 --> 00:09:56,100
+limit
+
+105
+00:10:02,600 --> 00:10:09,880
+زاد خواص تاني طبعا
+
+106
+00:10:09,880 --> 00:10:19,420
+ال endurance limit اللي مُعطاه في ال table A24 ال
+
+107
+00:10:19,420 --> 00:10:23,100
+endurance limit اللي مُعطاه في ال table 24 ال
+
+108
+00:10:23,100 --> 00:10:28,360
+already includes ال K A و ال K B ال endurance
+
+109
+00:10:28,360 --> 00:10:33,780
+limit given in table 24 already includeالـ K A و
+
+110
+00:10:33,780 --> 00:10:37,660
+ال K B ال K A اللي هو ال modification factor for
+
+111
+00:10:37,660 --> 00:10:41,060
+the surface finish و ال K B ال modification factor
+
+112
+00:10:41,060 --> 00:10:42,140
+for size
+
+113
+00:10:45,110 --> 00:10:49,610
+والـ average value KC for axial and torsional
+
+114
+00:10:49,610 --> 00:10:54,370
+loading is 0.9 طبعا في حالة bending بتكون ال KC
+
+115
+00:10:54,370 --> 00:10:59,750
+بيستوي واحد يعني احنا في حالة ال cast iron هنستخدم
+
+116
+00:10:59,750 --> 00:11:05,110
+table A24 من table A24 بنطلع ال S S .. بنطلع اللي
+
+117
+00:11:05,110 --> 00:11:12,980
+هو ال S UT و ال S UCوبنطلع ال SE prime SE prime
+
+118
+00:11:12,980 --> 00:11:16,340
+already متضمن فيها اللي هو ال surface finish
+
+119
+00:11:16,340 --> 00:11:20,680
+factor و ال size factor اللي هو ان في حالة bending
+
+120
+00:11:20,680 --> 00:11:24,780
+load بتكون ال KC بساوة واحد في حالة axle او
+
+121
+00:11:24,780 --> 00:11:32,200
+torsion load ال KC هنحطها تسعة من عشرة نشوف
+
+122
+00:11:32,200 --> 00:11:32,980
+و نحل المثال
+
+123
+00:11:50,490 --> 00:11:56,130
+a grade thirty gray cast iron يعني عندي حديد سكب
+
+124
+00:11:56,130 --> 00:12:06,930
+اللي هو cast iron grade تلاتين
+
+125
+00:12:09,610 --> 00:12:13,710
+is subjected to a load applied to a one point by
+
+126
+00:12:13,710 --> 00:12:17,450
+three seven inch cross section link with one
+
+127
+00:12:17,450 --> 00:12:20,330
+fourth inch diameter hole drilled in the center
+
+128
+00:12:20,330 --> 00:12:30,150
+بيبين دي شكل هين عندي قطعة معدنيةمستطيلة المقطع
+
+129
+00:12:30,150 --> 00:12:32,950
+بتاعها مستطيل السماكة القطعة تلاتة ع تمانية انش
+
+130
+00:12:32,950 --> 00:12:40,470
+وعرض القطعة واحد انش وفي force tension force F وفي
+
+131
+00:12:40,470 --> 00:12:52,410
+هنا في النص ثقب كتر ربع انش كتر ثقب ربع انش The
+
+132
+00:12:52,410 --> 00:12:56,870
+surfaces are machined الأسطح machined
+
+133
+00:13:02,640 --> 00:13:05,980
+in the neighborhood of the hole على مقرب من الثقب
+
+134
+00:13:05,980 --> 00:13:10,580
+what is the factor of safety guarding against
+
+135
+00:13:10,580 --> 00:13:13,660
+fatigue against failure under the following
+
+136
+00:13:13,660 --> 00:13:19,640
+conditions بده ال factor of safety against failure
+
+137
+00:13:19,640 --> 00:13:22,200
+في الحالات التالية الحالة الأولى
+
+138
+00:13:25,700 --> 00:13:30,100
+الـ load ال F بساوة
+
+139
+00:13:30,100 --> 00:13:38,700
+ألف pound steady steady
+
+140
+00:13:38,700 --> 00:13:42,820
+يعني ثابتة يعني في الحال هذا هتكون عندى ال F
+
+141
+00:13:42,820 --> 00:13:51,700
+alternating بساوة سفر وال F mean بساوة ألف pound
+
+142
+00:13:51,700 --> 00:13:54,120
+بده ال factor of safety
+
+143
+00:14:04,810 --> 00:14:12,670
+يعني .. يعني هذه النقطة هتكون طبعا
+
+144
+00:14:12,670 --> 00:14:16,230
+عشان احسب ال stress .. اول شي طبعا خلينا اول شي
+
+145
+00:14:16,230 --> 00:14:21,730
+نطلع .. نطلع الخواص الميكانيكي اول شي هو cast iron
+
+146
+00:14:21,730 --> 00:14:26,310
+اول شي هو cast iron بمعناته هنروح على ال table A24
+
+147
+00:14:26,310 --> 00:14:29,450
+هو
+
+148
+00:14:29,450 --> 00:14:30,390
+grade 30
+
+149
+00:14:33,870 --> 00:14:38,430
+جريد تلاتين معناته
+
+150
+00:14:38,430 --> 00:14:48,830
+ال SUT نروح على التابل A24 ستكون ال SUT بالساوية
+
+151
+00:14:48,830 --> 00:14:53,050
+واحد تلاتين كيلو pound per square inch واحد تلاتين
+
+152
+00:14:53,050 --> 00:15:01,550
+كيلو pound per square inch وال SUC مية وتسعة
+
+153
+00:15:05,160 --> 00:15:17,620
+بس هو مية وتسعة كيلو pound per square inch و
+
+154
+00:15:17,620 --> 00:15:23,020
+ال endurance limit عندي ال SE prime اربعتاش و ال
+
+155
+00:15:23,020 --> 00:15:28,940
+SE prime اربعتاشر
+
+156
+00:15:28,940 --> 00:15:31,780
+كيلو pound per square inch
+
+157
+00:15:39,450 --> 00:15:45,430
+طيب نرجع لمسألة تاتنا عرفنا الخواص الميكانيكية
+
+158
+00:15:45,430 --> 00:15:49,990
+الآن
+
+159
+00:16:07,700 --> 00:16:10,860
+الان ال cross section ال area .. ال area بتاعة ال
+
+160
+00:16:10,860 --> 00:16:17,900
+cross section المقطع هنا هيكون لو
+
+161
+00:16:17,900 --> 00:16:22,820
+اتاخد مقطع عند الثقب
+
+162
+00:16:38,760 --> 00:16:45,680
+هذه ثلاثة على تمانية انش
+
+163
+00:16:45,680 --> 00:16:55,020
+وهذه واحد انش كلها وهذه
+
+164
+00:16:55,020 --> 00:17:05,480
+ربع انش معناته
+
+165
+00:17:05,480 --> 00:17:06,160
+هذه ستكون
+
+166
+00:17:24,220 --> 00:17:31,460
+هتكون واحد ناقص ربع تلت اربع على اتنين بون تلاتة
+
+167
+00:17:31,460 --> 00:17:40,340
+سبعة خمسة انش بون تلاتة سبعة خمسة انش معناته مساحة
+
+168
+00:17:40,340 --> 00:17:43,320
+ال net cross sectional area هتكون مساحة المستطيل
+
+169
+00:17:43,320 --> 00:17:51,800
+هذا زاد المستطيل هذا ال area بتاعة المقطع هتساوي
+
+170
+00:17:53,210 --> 00:17:58,230
+اللي هو تلاتة على تمانية في
+
+171
+00:17:58,230 --> 00:18:03,370
+أو
+
+172
+00:18:03,370 --> 00:18:06,930
+المستطيل هذا كله ناقص المستطيل الصغير اللي هو
+
+173
+00:18:06,930 --> 00:18:16,390
+تلاتة على تمانية في واحد ناقص
+
+174
+00:18:16,390 --> 00:18:17,590
+ربع
+
+175
+00:18:39,620 --> 00:18:45,300
+وبتطلع بونت اتنين تمانية واحد
+
+176
+00:18:45,300 --> 00:18:54,400
+اتنين خمسة انش مربع معناته
+
+177
+00:18:54,400 --> 00:19:00,620
+ال mean stress ال sigma alternating هتكون صحيح صفر
+
+178
+00:19:00,620 --> 00:19:06,500
+و ال sigma mean اللي هو ال nominal هتكون صحيح FM
+
+179
+00:19:09,230 --> 00:19:19,290
+FM على ال .. على ال .. على ال area FM اللي هى الف
+
+180
+00:19:19,290 --> 00:19:26,390
+ع ال area اللي هى point اتنين تمانية واحد اتنين
+
+181
+00:19:26,390 --> 00:19:29,950
+خمسة طبعا لو دي حوالي كيلو pound per square inch
+
+182
+00:19:29,950 --> 00:19:30,690
+هتكون
+
+183
+00:19:33,940 --> 00:19:43,560
+الف تقسيم point اتنين تمانية واحد اتنين خمسة تطلع
+
+184
+00:19:43,560 --> 00:19:49,260
+تلاتة point خمسة
+
+185
+00:19:49,260 --> 00:19:55,500
+خمسة ستة kilo pound per square inch
+
+186
+00:20:17,990 --> 00:20:24,930
+طيب بلزان نحسب ال KT لأن فعل دي هكون stress
+
+187
+00:20:24,930 --> 00:20:29,310
+concentration عشان
+
+188
+00:20:29,310 --> 00:20:33,730
+نحسب ال stress concentration
+
+189
+00:20:38,290 --> 00:20:42,490
+بلزمنا نحسب الـ KT نرجع لجداول اللي هو ال table
+
+190
+00:20:42,490 --> 00:20:43,150
+A15
+
+191
+00:21:18,180 --> 00:21:27,580
+لو هيكون a خمستاش واحد ليها دي
+
+192
+00:21:27,580 --> 00:21:33,740
+بلزمنا
+
+193
+00:21:33,740 --> 00:21:41,860
+d على w دي هيكون ان دي a خمستاش واحد بدي احسب d
+
+194
+00:21:41,860 --> 00:21:49,250
+على w دي اللي هي ربع على ال wاللي هي واحد انش
+
+195
+00:21:49,250 --> 00:21:56,430
+بيساوي point اتنين خمسة الان point اتنين خمسة احنا
+
+196
+00:21:56,430 --> 00:22:10,350
+هنكون هنا تقريبا
+
+197
+00:22:10,350 --> 00:22:15,350
+تطلع الكاتي اتنين
+
+198
+00:22:15,350 --> 00:22:29,930
+pointاربعة خمسة ال
+
+199
+00:22:29,930 --> 00:22:32,590
+keto طلعت nine point اربعة خمسة
+
+200
+00:23:08,170 --> 00:23:11,470
+طيب معناته استخدمنا ال table A 15 واحد عشان اطلع
+
+201
+00:23:11,470 --> 00:23:13,010
+ال stress concentration factor
+
+202
+00:23:47,200 --> 00:23:57,340
+في الحالة هذه النقطة على ال curve هي sigma mean و
+
+203
+00:23:57,340 --> 00:24:01,120
+sigma alternating النقطة هذه عبارة عن sigma
+
+204
+00:24:01,120 --> 00:24:04,700
+alternating صفر و sigma mean بساوية تلاتة point
+
+205
+00:24:04,700 --> 00:24:06,340
+خمسة خمسة ستة
+
+206
+00:24:31,600 --> 00:24:40,740
+طيب ال .. ال .. ال cast iron ال cast iron is
+
+207
+00:24:40,740 --> 00:24:43,240
+not sensitive
+
+208
+00:24:45,830 --> 00:25:06,270
+to notches في حالة in case of static loading يعني
+
+209
+00:25:06,270 --> 00:25:13,070
+ممكن احكي الان في الحالة هذهبالسواء SUT على Sigma
+
+210
+00:25:13,070 --> 00:25:20,630
+او الـ SUT اللي هي طلعناها
+
+211
+00:25:20,630 --> 00:25:25,350
+واحد و تلاتين على
+
+212
+00:25:25,350 --> 00:25:30,070
+واحد
+
+213
+00:25:30,070 --> 00:25:35,750
+و تلاتين على تلاتة point خمسة خمسة ستة
+
+214
+00:25:38,980 --> 00:25:46,120
+بس انا مع ذلك انا بفضل .. بفضل .. بفضل
+
+215
+00:25:46,120 --> 00:25:51,580
+اجي احكي انه ال sigma M هتكون في سواء KT في sigma
+
+216
+00:25:51,580 --> 00:25:58,800
+MA اللي هي هتكون تلاتة point اتنين point اربع خمسة
+
+217
+00:25:58,800 --> 00:26:02,640
+في تلاتة point خمسة خمسة ستة تطلع
+
+218
+00:26:26,100 --> 00:26:32,660
+تمانية bond السابعة واحد
+
+219
+00:26:32,660 --> 00:26:37,700
+اتنين اتنين المعنى
+
+220
+00:26:37,700 --> 00:26:43,240
+اللي بحكي ان ال N حساوي S U T على S M اللي هي
+
+221
+00:26:43,240 --> 00:26:46,920
+هتكون واحد تلاتين على تمانية bond السابعة واحد
+
+222
+00:26:46,920 --> 00:26:48,260
+اتنين اتنين
+
+223
+00:26:55,910 --> 00:27:06,490
+هتكون عندى تلاتة
+
+224
+00:27:06,490 --> 00:27:11,730
+point هذا
+
+225
+00:27:11,730 --> 00:27:17,990
+المطلوب الأول المطلوب التانى من نفس ال factor of
+
+226
+00:27:17,990 --> 00:27:21,230
+safety في حال كان ال load is repeatedly applied
+
+227
+00:27:24,970 --> 00:27:31,750
+المطلوب التاني ب .. ال load repeatedly applied
+
+228
+00:27:31,750 --> 00:27:37,310
+يعني بتغير بين zero و maximum value ألف ال F
+
+229
+00:27:37,310 --> 00:27:46,310
+minimum بالساوية zero وال F maximum بالساوية الف
+
+230
+00:27:46,310 --> 00:27:51,470
+pound في الحلقة دي هنحس أنه هيطلع عند ال F mean
+
+231
+00:27:52,900 --> 00:28:01,220
+بيستوي F alternating بيستوي الف على اتنين بيطلع
+
+232
+00:28:01,220 --> 00:28:08,540
+خمسمية pound الحسب
+
+233
+00:28:08,540 --> 00:28:20,390
+انا KF هسه واحد زاد Q في KT minus واحدالـ Q في
+
+234
+00:28:20,390 --> 00:28:23,290
+حالة الcast iron نعتبرها ايه في الساوية اتنين من
+
+235
+00:28:23,290 --> 00:28:27,970
+عشرة حتسة واحد زاد اتنين من عشرة في كتي اللي هي
+
+236
+00:28:27,970 --> 00:28:35,590
+اتنين point اربع خمسة ناقص واحد حتطلع
+
+237
+00:28:48,790 --> 00:28:58,730
+أتنين نقل اتنين تسعة ستكون
+
+238
+00:28:58,730 --> 00:29:07,530
+دي sigma a سواء sigma M سواء KF في
+
+239
+00:29:07,530 --> 00:29:11,190
+اللي
+
+240
+00:29:11,190 --> 00:29:17,280
+هي F mean أو F alternating على ال areaيعني هتكون
+
+241
+00:29:17,280 --> 00:29:23,280
+الكافي عندي واحد point اتنين تسعة في ال FM 500 وال
+
+242
+00:29:23,280 --> 00:29:29,680
+A عندي point اتنين point اتنين تمانية واحد اتنين
+
+243
+00:29:29,680 --> 00:29:30,760
+خمسة
+
+244
+00:29:35,840 --> 00:29:42,420
+عندى one point اتنين تسعة في خمسمية تقسيم point
+
+245
+00:29:42,420 --> 00:29:50,820
+اتنين تمانية واحد اتنين خمسة في ساوي تطلع اتنين
+
+246
+00:29:50,820 --> 00:29:56,120
+point تسعة
+
+247
+00:29:56,120 --> 00:30:01,600
+تلاتة kilo pound per square inch الان بنجى بنعمل
+
+248
+00:30:01,600 --> 00:30:02,400
+plot هنا
+
+249
+00:30:05,290 --> 00:30:10,890
+هتكون نقطة هذه اللي
+
+250
+00:30:10,890 --> 00:30:16,050
+هي عندك اتنين point اتنين تسعة تلاتة و اتنين point
+
+251
+00:30:16,050 --> 00:30:18,690
+اتنين تسعة تلاتة احنا في first quadrant هذا ال
+
+252
+00:30:18,690 --> 00:30:29,040
+load line هذا ال load line في الحالة هذه Rبساوة
+
+253
+00:30:29,040 --> 00:30:37,040
+sigma a ع sigma m بساوة واحد في حال انا كنت في ال
+
+254
+00:30:37,040 --> 00:30:49,340
+first quadrant بستخدم المعادلة اللي هي SA بساوة
+
+255
+00:30:49,340 --> 00:30:53,620
+RSUT زائد SE
+
+256
+00:31:00,910 --> 00:31:08,790
+زائد SE على اتنين في minus واحد زائد جزر التربيع
+
+257
+00:31:08,790 --> 00:31:24,510
+لواحد زائد اربعة R S U T SE على R S U T زائد SE
+
+258
+00:31:24,510 --> 00:31:31,270
+لكل تربيعلحظة ان احنا ال SE لحد تاني ما جيبناهاش
+
+259
+00:31:31,270 --> 00:31:36,130
+احنا حكينا ال K A و ال K B included معناته هتكون
+
+260
+00:31:36,130 --> 00:31:45,010
+عنده ال SE هتكون سوى K A K B SE prime هذه included
+
+261
+00:31:45,010 --> 00:31:50,730
+في KC يعني هتكون عنده انا already طلعت اللي هي SE
+
+262
+00:31:50,730 --> 00:31:57,170
+prime اللي هي اربعتاش في KC تسعة من عشرةأنا هكون
+
+263
+00:31:57,170 --> 00:32:04,890
+اربعة طرف تسعة و ناشرة بطلع
+
+264
+00:32:04,890 --> 00:32:12,050
+اتناش point ستة kilo pound per square inch معناته
+
+265
+00:32:12,050 --> 00:32:19,490
+ال S A هتكون تساوي ال R عندي واحد ال S U T عندي
+
+266
+00:32:19,490 --> 00:32:29,340
+واحد تلاتينزائد اتناش point ستة على اتنين في minus
+
+267
+00:32:29,340 --> 00:32:35,240
+واحد زائد جزر التربيع لواحد زائد اربعة R اللي هي
+
+268
+00:32:35,240 --> 00:32:40,320
+واحد في ال SUT واحد وتلاتين في ال SE اتناش point
+
+269
+00:32:40,320 --> 00:32:47,840
+ستة على اللي هي واحد تلاتين زائد اتناش point ستة
+
+270
+00:32:47,840 --> 00:32:50,120
+لكل تربيع
+
+271
+00:32:59,970 --> 00:33:09,090
+هتطلع اربعة في واحد تلاتين في اتناش point ستة
+
+272
+00:33:09,090 --> 00:33:16,250
+تقسيم تلاتة
+
+273
+00:33:16,250 --> 00:33:20,670
+في تلاتين point ستة تقسيم
+
+274
+00:33:23,040 --> 00:33:34,440
+ستة يساوي زائد واحد تحت الجزر المهم بنحسبها تطلع
+
+275
+00:33:34,440 --> 00:33:42,800
+عندنا الاش بنحسب ال S A ال
+
+276
+00:33:42,800 --> 00:33:45,600
+S A هتطلع عندي سبعة اربعين ستة تلاتة
+
+277
+00:33:49,150 --> 00:33:54,890
+kilo pound per square inch ومنها بحث بال factor of
+
+278
+00:33:54,890 --> 00:34:01,850
+safety انه هيكون الساوى S A على Sigma A S A اللي
+
+279
+00:34:01,850 --> 00:34:10,470
+هي سبعة point ستة تلاتة على Sigma
+
+280
+00:34:10,470 --> 00:34:16,090
+A اللي هي احنا حسبناها اتنين point اتنين تسعة
+
+281
+00:34:16,090 --> 00:34:16,890
+تلاتة
+
+282
+00:34:29,380 --> 00:34:34,700
+تطلع تلاتة بقون تلاتة اتنين تمانية تلاتة بقون
+
+283
+00:34:34,700 --> 00:34:38,440
+تلاتة اتنين تمانية ال factor of safety هذه الحالة
+
+284
+00:34:38,440 --> 00:34:41,960
+التانية ال
+
+285
+00:34:41,960 --> 00:34:46,560
+case التالتة ال
+
+286
+00:34:46,560 --> 00:34:53,840
+case التالتة ال load fluctuates between minus one
+
+287
+00:34:53,840 --> 00:34:58,180
+thousand and three hundred pounds حالة التالتة
+
+288
+00:35:12,150 --> 00:35:19,630
+الحالة التالتة ال load بترجح بين ناقص الف و
+
+289
+00:35:19,630 --> 00:35:31,510
+تلاتمية pound يعني F minimum F
+
+290
+00:35:31,510 --> 00:35:40,780
+minimum بيصبح minus الف poundو F maximum بالساوية
+
+291
+00:35:40,780 --> 00:35:49,420
+تلاتمية pound معناته ال F mean هتكون ساوية minus
+
+292
+00:35:49,420 --> 00:35:58,420
+الف زائد تلاتمية على اتنين يعني minus سبعمية على
+
+293
+00:35:58,420 --> 00:36:05,960
+اتنين ماقص تلاتمية و خمسين pound وال F alternating
+
+294
+00:36:08,200 --> 00:36:17,820
+هيكون تلاتمية ناقص ناقص الف على اتنين يعني هيكون
+
+295
+00:36:17,820 --> 00:36:30,540
+الف تلاتمية على اتنين ستمية و خمسين found من
+
+296
+00:36:30,540 --> 00:36:40,070
+هنا بنحسب ال sigma M سواء KFفى FM على الـ Area
+
+297
+00:36:40,070 --> 00:36:46,930
+الكاف الرودي احنا حسبنا واحد point اتنين تسعة فى
+
+298
+00:36:46,930 --> 00:36:59,830
+ال FM تلتمية وخمسين سالب تلتمية وخمسين ع
+
+299
+00:36:59,830 --> 00:37:06,390
+ال Area على point اتنين تمانية واحد اتنين خمسة
+
+300
+00:37:07,430 --> 00:37:16,630
+هتكون سالب واحد
+
+301
+00:37:16,630 --> 00:37:26,390
+point اتنين تسعة في تلت مية و خمسين تقسيم point
+
+302
+00:37:26,390 --> 00:37:30,910
+اتنين تمانية واحد اتنين خمسة بيطلع واحد point
+
+303
+00:37:30,910 --> 00:37:36,270
+ستمية و خمسين minus واحد kilo pound per square
+
+304
+00:37:36,270 --> 00:37:45,290
+inchالـ Sigma alternating هتكون سوى KF في F
+
+305
+00:37:45,290 --> 00:37:54,510
+alternating على ال area أو بيسوى Sigma M بيسوى
+
+306
+00:37:54,510 --> 00:38:06,070
+Sigma M على FM في F alternating هي هي هي هتكون
+
+307
+00:38:06,920 --> 00:38:07,460
+1
+
+308
+00:38:07,460 --> 00:38:19,780
+.605ﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻ�
+
+309
+00:38:41,440 --> 00:38:45,560
+تطلع اتنين بون تسعة تمانية واحد اتنين بون تسعة
+
+310
+00:38:45,560 --> 00:38:54,940
+تمانية واحد كيلو pound per square inch نجي نعمل
+
+311
+00:38:54,940 --> 00:39:02,060
+plot طبعا عند ال sigma mean سالب sigma mean سالب
+
+312
+00:39:02,060 --> 00:39:07,080
+اللي
+
+313
+00:39:07,080 --> 00:39:12,780
+هي ناقصواحد point ستمية وخمس فانات وانا في ال
+
+314
+00:39:12,780 --> 00:39:18,640
+second quadrant و ال sigma alternating اللي هي
+
+315
+00:39:18,640 --> 00:39:23,600
+اتنين point تسعة تمانية واحد طبعا هذا ال load line
+
+316
+00:39:23,600 --> 00:39:29,220
+وهذا
+
+317
+00:39:29,220 --> 00:39:37,720
+ال failure line هذا هتكون S alternating وهذا هتكون
+
+318
+00:39:40,230 --> 00:39:50,770
+S M و ال R سيكون سيجما alternating على سيجما M
+
+319
+00:39:50,770 --> 00:39:57,150
+بالساوي اللي هو اتنين point تسعة تمانية واحد على
+
+320
+00:39:57,150 --> 00:40:05,290
+minus واحد point ستة سفر خمسة عشان
+
+321
+00:40:05,290 --> 00:40:08,810
+نحسب احنا في second quadrant ستكون ال S A
+
+322
+00:40:18,750 --> 00:40:29,330
+الـ ال S A بتساوي
+
+323
+00:40:29,330 --> 00:40:33,570
+S E زائد
+
+324
+00:40:33,570 --> 00:40:41,370
+S E على S U T minus واحد
+
+325
+00:40:45,570 --> 00:40:55,430
+في S M طبعا
+
+326
+00:40:55,430 --> 00:41:06,710
+ال R مش سوى S A برضه على S M يعني
+
+327
+00:41:06,710 --> 00:41:10,610
+مش
+
+328
+00:41:10,610 --> 00:41:22,150
+سوى Rمعناته عنده الـ S M بسوا S A على R يعني هذه
+
+329
+00:41:22,150 --> 00:41:31,550
+المعادة اللي حاسبها عندى S A بسوا S E زائد S E على
+
+330
+00:41:31,550 --> 00:41:41,290
+S U T minus واحد في S A على R ومنها بحسب الـ S A
+
+331
+00:41:42,260 --> 00:41:47,960
+بحث في ال S A هتطلع ال
+
+332
+00:41:47,960 --> 00:41:54,500
+S A هتطلع طمنتاش و نص كيلو
+
+333
+00:41:54,500 --> 00:41:59,640
+pound per square inch معناته هيكون عندي طمنتاش و
+
+334
+00:41:59,640 --> 00:42:05,920
+نص كيلو pound per square inch معناته الفاكره ال
+
+335
+00:42:05,920 --> 00:42:13,160
+safety N هيكون الساوي S Aعلى الـ Sigma A الـ S A
+
+336
+00:42:13,160 --> 00:42:19,980
+اللي هي اللي هي تمانتاش
+
+337
+00:42:19,980 --> 00:42:26,000
+و نص على ال Sigma A اتنين point تسعة تمانية واحد
+
+338
+00:42:26,000 --> 00:42:32,220
+تمانتاش
+
+339
+00:42:32,220 --> 00:42:38,760
+و نص تقسيم اتنين point تسعة تمانية واحد تلعب ستة
+
+340
+00:42:38,760 --> 00:42:39,560
+point اتنين
+
+341
+00:42:43,700 --> 00:42:49,300
+ستة bond اتنين سفر ستة factor of six هيك يكون
+
+342
+00:42:49,300 --> 00:42:50,820
+خلصنا المسألة
+
+343
+00:43:52,480 --> 00:43:58,200
+انكمل على موضوع جديد نشوف اللي هو مصطلح دي اللي هو
+
+344
+00:43:58,200 --> 00:44:03,080
+torsional fatigue strength احنا
+
+345
+00:44:03,080 --> 00:44:06,540
+ناخد بعض الملاحظات اولا اذا عندي steady stress
+
+346
+00:44:06,540 --> 00:44:09,280
+component has no effect on the endurance limit for
+
+347
+00:44:09,280 --> 00:44:12,660
+torsional loading if the material اذا كان عندي ال
+
+348
+00:44:12,660 --> 00:44:18,260
+torsional load is steady مش هيكون له تأثير على ال
+
+349
+00:44:18,260 --> 00:44:22,960
+endurance limitفي حال ال material كانت دكتايل
+
+350
+00:44:22,960 --> 00:44:30,140
+polished خالية من الخدوش و المقطعتها مدور يعني في
+
+351
+00:44:30,140 --> 00:44:35,840
+حال كانت ال material دكتايل polished خالية من
+
+352
+00:44:35,840 --> 00:44:44,680
+الخدوش و مقطعتها مدور في الحالة هذهو كان ال .. ال
+
+353
+00:44:44,680 --> 00:44:45,880
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+354
+00:44:45,880 --> 00:44:46,020
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+355
+00:44:46,020 --> 00:44:46,480
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+356
+00:44:46,480 --> 00:44:47,120
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+357
+00:44:47,120 --> 00:44:47,420
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+358
+00:44:47,420 --> 00:44:52,360
+.. ال .. ال .. ال .. ال .. ال ..
+
+359
+00:44:52,360 --> 00:44:55,960
+ال ..
+
+360
+00:44:55,960 --> 00:44:57,900
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+361
+00:44:57,900 --> 00:44:57,940
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+362
+00:44:57,940 --> 00:44:57,980
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+363
+00:44:57,980 --> 00:44:58,040
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+364
+00:44:58,040 --> 00:45:03,640
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+365
+00:45:03,640 --> 00:45:08,540
+ال ..
+
+366
+00:45:13,090 --> 00:45:17,850
+for less than perfect surfaces يعني ال surface ما
+
+367
+00:45:17,850 --> 00:45:25,310
+كان polished و ممكن كان فيه notches the modified
+
+368
+00:45:25,310 --> 00:45:27,670
+godman line is more reasonable الحالة دي نستخدم
+
+369
+00:45:27,670 --> 00:45:32,610
+modified godman linefor pure torsion cases في حالة
+
+370
+00:45:32,610 --> 00:45:36,410
+عندى ال mechanical member متعرض ل pure torsion
+
+371
+00:45:36,410 --> 00:45:42,570
+بنستخدم ال KC 0.59 to convert normal endurance
+
+372
+00:45:42,570 --> 00:45:45,430
+strength to sheer endurance strength يعني انا عندى
+
+373
+00:45:45,430 --> 00:45:49,930
+SE وفي
+
+374
+00:45:49,930 --> 00:45:54,670
+عندى SES
+
+375
+00:45:54,670 --> 00:45:57,730
+عشان احسب ال SES
+
+376
+00:46:02,670 --> 00:46:08,990
+الـ SE س هتكون point خمسة تسعة في ال SE ال normal
+
+377
+00:46:08,990 --> 00:46:15,770
+for shear ان احنا .. احنا عندنا في حالة ال tensile
+
+378
+00:46:15,770 --> 00:46:21,130
+loading عندنا ال SUT في حالة ال shear عندنا يقبلها
+
+379
+00:46:21,130 --> 00:46:29,130
+اللي هو ال shear ultimate strength SSU ال SSU
+
+380
+00:46:31,280 --> 00:46:41,020
+بالساوية point 6 7 S U T يعني
+
+381
+00:46:41,020 --> 00:46:45,680
+في حالة torsional fatigueloading it is reasonable
+
+382
+00:46:45,680 --> 00:46:51,360
+to use modified Godman line استخدم KC to convert
+
+383
+00:46:51,360 --> 00:46:55,160
+from normal endurance strength to sheer endurance
+
+384
+00:46:55,160 --> 00:47:00,760
+strength هتكون ال SE S بسبب وانت خمسة تسعة SE و
+
+385
+00:47:00,760 --> 00:47:05,320
+convert ال .. يعني بدك تحول من ultimate tensile
+
+386
+00:47:05,320 --> 00:47:08,880
+strength ل sheer ultimate strength اللي هو SSU
+
+387
+00:47:08,880 --> 00:47:10,560
+بسبب وانت ستة سبعة SUT
+
+388
+00:47:14,630 --> 00:47:21,290
+طيب نيجي لل combinations of loading modes for
+
+389
+00:47:21,290 --> 00:47:24,590
+combined loading condition combined loading يعني
+
+390
+00:47:24,590 --> 00:47:27,790
+ممكن يكون عندي axial loading مع bending loading مع
+
+391
+00:47:27,790 --> 00:47:31,750
+torsional loading هنستخدم ال distortion energy
+
+392
+00:47:31,750 --> 00:47:37,850
+theorem to combine them يعني هنحسب von Mises
+
+393
+00:47:37,850 --> 00:47:42,350
+stress so one can alternating von Mises او mid
+
+394
+00:47:42,350 --> 00:47:43,390
+range von Mises
+
+395
+00:47:46,760 --> 00:47:54,320
+then we apply KF to each type of stress في حالة ال
+
+396
+00:47:54,320 --> 00:47:58,100
+load factor use KC جوه المعادلة
+
+397
+00:48:01,730 --> 00:48:05,270
+The torsion load factor Kc equal point five nine
+
+398
+00:48:05,270 --> 00:48:08,190
+is inherently included in the von Mises equations
+
+399
+00:48:08,190 --> 00:48:13,550
+سنستخدم المعادلات التالية sigma prime A هي von
+
+400
+00:48:13,550 --> 00:48:16,290
+Mises alternating وعندي معادلة sigma prime M هي
+
+401
+00:48:16,290 --> 00:48:23,130
+von Mises mean طبعا تفاصيلها بتساوي Kf due to
+
+402
+00:48:23,130 --> 00:48:27,670
+bendingفي sigma alternating due to bending زاد كف
+
+403
+00:48:27,670 --> 00:48:31,910
+كف due to axial loading في sigma alternating due
+
+404
+00:48:31,910 --> 00:48:34,910
+to axial loading على point eight five الكل تربية
+
+405
+00:48:34,910 --> 00:48:40,730
+يعني ال course ده بيحتوي كل ال normal stress due
+
+406
+00:48:40,730 --> 00:48:46,230
+to bending و due to axial loading لاحظ ال stress
+
+407
+00:48:46,230 --> 00:48:49,130
+concentration effect is included for both bending
+
+408
+00:48:49,130 --> 00:48:51,710
+and for both axial loading
+
+409
+00:48:57,130 --> 00:49:04,790
+زائد تلاتة KFS اللي هو fatigue concentration
+
+410
+00:49:04,790 --> 00:49:09,150
+factor due to torsion في tau alternating اللي هو
+
+411
+00:49:09,150 --> 00:49:12,790
+alternating shear stress component لكل تربيع قص نص
+
+412
+00:49:12,790 --> 00:49:17,010
+نفس المعادلة في حالةال ال ال ال ال ال ال ال ال ال
+
+413
+00:49:17,010 --> 00:49:17,670
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+414
+00:49:17,670 --> 00:49:20,090
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+415
+00:49:20,090 --> 00:49:25,150
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+416
+00:49:25,150 --> 00:49:26,970
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+417
+00:49:26,970 --> 00:49:27,350
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+418
+00:49:27,350 --> 00:49:29,190
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+419
+00:49:29,190 --> 00:49:29,490
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+420
+00:49:29,490 --> 00:49:29,870
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+421
+00:49:29,870 --> 00:49:29,910
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+422
+00:49:29,910 --> 00:49:33,750
+ال ال ال ال ال ال ال ال ال ال ال ال
+
+423
+00:49:47,970 --> 00:49:52,270
+distortion energy theory still applies for check
+
+424
+00:49:52,270 --> 00:49:58,670
+against yielding يعني انا في الأول في حالة يعني
+
+425
+00:49:58,670 --> 00:50:02,590
+انا بحسب sigma عندما اللي أخدت modified godman
+
+426
+00:50:02,590 --> 00:50:12,610
+modified godman جاء بين جاء بين ال sut و ال sa انا
+
+427
+00:50:12,610 --> 00:50:18,960
+هحسب sigma primemain و sigma prime alternating
+
+428
+00:50:18,960 --> 00:50:22,720
+وهذا
+
+429
+00:50:22,720 --> 00:50:30,040
+ال load line هذا ال load line بنفس المنطقة بحسب
+
+430
+00:50:30,040 --> 00:50:38,240
+sigma sm وبحسب
+
+431
+00:50:39,890 --> 00:50:46,970
+S A و ال factor of safety N F بالساوية بالساوية
+
+432
+00:50:46,970 --> 00:50:55,250
+اللي هو S M على Sigma M Prime بالساوية S A على
+
+433
+00:50:55,250 --> 00:50:58,830
+Sigma A Prime ممكن افحص against yielding هنا عندي
+
+434
+00:50:58,830 --> 00:51:04,670
+S Y و هنا S
+
+435
+00:51:04,670 --> 00:51:05,230
+Y
+
+436
+00:51:08,080 --> 00:51:15,780
+بالحالة هذه هحسب SM due to yielding و SA due to
+
+437
+00:51:15,780 --> 00:51:18,300
+yielding هنرجع لل tables اللي ذكرناهم في هذا ال
+
+438
+00:51:18,300 --> 00:51:29,640
+chapter السابق الآن
+
+439
+00:51:29,640 --> 00:51:35,430
+to check against yielding بدي احسب ال maximumVon
+
+440
+00:51:35,430 --> 00:51:40,430
+Mises Stress بحث في ال maximum Von Mises Stress
+
+441
+00:51:40,430 --> 00:51:43,270
+يعني من المعادلة هذه sigma prime maximum بيستوى
+
+442
+00:51:43,270 --> 00:51:49,050
+sigma a زي sigma M لكل تربيع زي تلاتة تاو a زي تاو
+
+443
+00:51:49,050 --> 00:51:53,250
+M لكل تربيع اقصد نص ومنها بحث في الانواع بيستوى SY
+
+444
+00:51:53,250 --> 00:51:58,680
+على sigma maximum primeأو بعمل approximation بحكي
+
+445
+00:51:58,680 --> 00:52:02,360
+ال sigma prime maximum بالسواء sigma prime a زي
+
+446
+00:52:02,360 --> 00:52:05,740
+sigma prime m يعني اختصار .. يعني تقريبا مش .. مش
+
+447
+00:52:05,740 --> 00:52:08,620
+ميومية صح بس يعني إلى حد ما بتعطينا دقة مناسبة
+
+448
+00:52:08,620 --> 00:52:11,800
+اللي هي sigma prime maximum بالسواء sigma prime a
+
+449
+00:52:11,800 --> 00:52:22,900
+زي sigma prime m طيب
+
+450
+00:52:22,900 --> 00:52:24,860
+خلينا نحل example
+
+451
+00:52:33,130 --> 00:52:43,150
+A rotating shaft is made of 42 x 4 mm AISI 1018
+
+452
+00:52:43,150 --> 00:52:48,550
+cold drawn steel أولا الشيء ال material بتاعته ال
+
+453
+00:52:48,550 --> 00:52:58,870
+material AISI 1018 cold drawn steel
+
+454
+00:53:05,980 --> 00:53:20,380
+الـ shaft عبارة عن ال tube ال tube قطرها
+
+455
+00:53:20,380 --> 00:53:26,180
+الخارجي اتنين
+
+456
+00:53:26,180 --> 00:53:34,200
+و اربعين ملي و ال thickness بتاعها اربعة ملي
+
+457
+00:53:38,800 --> 00:53:44,740
+and has a six millimeter diameter hole draw
+
+458
+00:53:44,740 --> 00:53:55,920
+transverse يعني فيه hole قطر
+
+459
+00:53:55,920 --> 00:54:01,320
+ال hole ستة
+
+460
+00:54:01,320 --> 00:54:01,640
+millimeter
+
+461
+00:54:08,060 --> 00:54:13,060
+estimate the factor of safety guarding against
+
+462
+00:54:13,060 --> 00:54:18,880
+fatigue and static failures using the Gerber and
+
+463
+00:54:18,880 --> 00:54:21,740
+Langer failure criterion for the following loading
+
+464
+00:54:21,740 --> 00:54:24,720
+conditions من ناحية ال factor of safety guarding
+
+465
+00:54:24,720 --> 00:54:28,760
+against fatigue loading guarding against yielding
+
+466
+00:54:28,760 --> 00:54:32,500
+طبعا في حالة ال fatigue loading هستخدم ال gerber
+
+467
+00:54:32,500 --> 00:54:43,660
+criteria أول حالة case athe shaft case a the
+
+468
+00:54:43,660 --> 00:54:47,220
+shaft is subjected to a completely reversed torque
+
+469
+00:54:47,220 --> 00:54:54,860
+completely reversed torque يعني عندي ال torque
+
+470
+00:54:54,860 --> 00:54:59,320
+minimum بالسواء
+
+471
+00:54:59,320 --> 00:55:05,380
+ناقص مائة و عشرين نيوتر متر وال
+
+472
+00:55:05,380 --> 00:55:09,760
+torque maximumبس هو مية و عشرين نيوتن متر يعني
+
+473
+00:55:09,760 --> 00:55:16,840
+بتروح بين negative و positive in phase with a
+
+474
+00:55:16,840 --> 00:55:21,360
+completely reversed bending in phase with a
+
+475
+00:55:21,360 --> 00:55:25,080
+completely reversed bending وعندي bending كمان M
+
+476
+00:55:25,080 --> 00:55:33,600
+minimum so minus مية و خمسين نيوتن متر وال bending
+
+477
+00:55:33,600 --> 00:55:43,030
+maximum M maximum so مية و خمسينالنيوتن متر المعنى
+
+478
+00:55:43,030 --> 00:55:51,430
+في الحالة هذه هيكون عنده التاو او التيمين بتساوي
+
+479
+00:55:51,430 --> 00:55:58,940
+سفرو ال T alternating بالسواء مية و عشرين نيوتن
+
+480
+00:55:58,940 --> 00:56:06,820
+متر و نفس الأشياء ال M mean بالسواء سفر و ال M
+
+481
+00:56:06,820 --> 00:56:17,620
+alternating بالسواء مية و خمسين نيوتن متر طعم
+
+482
+00:56:17,620 --> 00:56:22,570
+الزمن انا في عندى two stressوعند stress
+
+483
+00:56:22,570 --> 00:56:26,070
+concentration لان هنروح على الجداول
+
+484
+00:56:58,690 --> 00:57:10,090
+هنستخدم اللي هو appendix A16 اه A16 هاي A16 فيه
+
+485
+00:57:10,090 --> 00:57:15,210
+عندى tube اللي لها القطر الخارجي و القطر الداخلي و
+
+486
+00:57:15,210 --> 00:57:21,990
+فيه ثقب مستعرض فيه ثقب مستعرض هذا في حالة ال .. ال
+
+487
+00:57:21,990 --> 00:57:22,530
+.. ال bending
+
+488
+00:57:25,760 --> 00:57:32,520
+الان احنا المعطيات اللي معطينا إياها ال A نطلع
+
+489
+00:57:32,520 --> 00:57:40,660
+الشكل ال A اللي
+
+490
+00:57:40,660 --> 00:57:47,580
+هي الثقب اللي هي ستة ميلي و
+
+491
+00:57:47,580 --> 00:57:48,820
+ال D capital
+
+492
+00:57:52,540 --> 00:57:57,640
+اللي هي اتنين و اربعين ملي والقطر الداخل دي small
+
+493
+00:57:57,640 --> 00:58:01,040
+دي
+
+494
+00:58:01,040 --> 00:58:05,460
+capital او القطر الخارجي القطر الداخل هيكون اتنين
+
+495
+00:58:05,460 --> 00:58:08,720
+و اربعين ناقص اربع ناقص اربع هيكون اتنين و اربعين
+
+496
+00:58:08,720 --> 00:58:15,720
+ناقص تمانية يعني هيكون اربع تلاتين ملي متر
+
+497
+00:58:23,030 --> 00:58:30,770
+هو الـ Sigma O بتساوي
+
+498
+00:58:30,770 --> 00:58:44,070
+M على ال section modulus على ال Z net الـ
+
+499
+00:58:44,070 --> 00:58:46,130
+M ال
+
+500
+00:58:49,840 --> 00:58:57,160
+في الجدول التحت معطيني عندي a على d بالزمن a على D
+
+501
+00:58:57,160 --> 00:59:14,160
+capital اللي هي 6 على 42 تطلع
+
+502
+00:59:14,160 --> 00:59:15,560
+point 1,4,3
+
+503
+00:59:24,400 --> 00:59:27,580
+ومعطينا different values for D على D انا D على D
+
+504
+00:59:27,580 --> 00:59:34,060
+اكم عنده D على D الفعلية اللى عندى D small على D
+
+505
+00:59:34,060 --> 00:59:38,720
+capital اللى هى اربعة وتلاتين على اتنين واربعين
+
+506
+00:59:38,720 --> 00:59:51,980
+اربعة تلاتين تطلع
+
+507
+00:59:51,980 --> 01:00:04,940
+point تمانيةبونت تمانية واحد بونت تمانية تقريبا
+
+508
+01:00:04,940 --> 01:00:13,980
+من
+
+509
+01:00:13,980 --> 01:00:18,580
+الجدول هذا هحسب ال a و ال kt اللي انا عندي اللي هو
+
+510
+01:00:18,580 --> 01:00:23,520
+a على d اللي هو بنت واحد اربعةاللي هي هتكون في
+
+511
+01:00:23,520 --> 01:00:38,700
+المنطقة هذه هي
+
+512
+01:00:38,700 --> 01:00:47,780
+عندي هنا point واحد اربعة تلاتة و D small على D
+
+513
+01:00:47,780 --> 01:00:49,200
+كبت هنا عندي تسعة من عشرة
+
+514
+01:00:52,610 --> 01:00:57,290
+وهنا عندي ستة من عشرة أنا التمام من عشرة جاي بين
+
+515
+01:00:57,290 --> 01:01:03,410
+الاتنين هدول و التمام من عشرة جاي وين؟ بينهم
+
+516
+01:01:03,410 --> 01:01:08,130
+معناته محتاج اعمل double interpolation double
+
+517
+01:01:08,130 --> 01:01:11,890
+interpolation يعني ال interpolation الأول يعني
+
+518
+01:01:11,890 --> 01:01:16,530
+هجيب عن d capital دي small عن d capital عن تسعة من
+
+519
+01:01:16,530 --> 01:01:18,030
+عشرة دي small
+
+520
+01:01:21,030 --> 01:01:26,790
+على دي capital هي عندي تسعة من عشرة وهي عندي ستة
+
+521
+01:01:26,790 --> 01:01:35,890
+من عشرة هحسب
+
+522
+01:01:35,890 --> 01:01:42,470
+ال A وال
+
+523
+01:01:42,470 --> 01:01:42,910
+KT
+
+524
+01:01:52,610 --> 01:01:56,910
+طيب ال interpolation ال A الأولى اللى هتكون خلانا
+
+525
+01:01:56,910 --> 01:02:01,870
+ندعم الواحدة و الباقية تعملوها لحالكوا ال A اللى
+
+526
+01:02:01,870 --> 01:02:08,110
+جاي هنا يعني فاندي واحدة هنا و واحدة هنا طبعا ال
+
+527
+01:02:08,110 --> 01:02:09,130
+table A 16
+
+528
+01:02:21,860 --> 01:02:25,120
+هتكون ال a الأولانية اللى عند ال a عند التسعة و
+
+529
+01:02:25,120 --> 01:02:29,480
+العشرة هتكون
+
+530
+01:02:29,480 --> 01:02:38,400
+تساوي point 82 زائد
+
+531
+01:02:38,400 --> 01:02:45,480
+point
+
+532
+01:02:45,480 --> 01:02:48,580
+143
+
+533
+01:02:49,370 --> 01:02:56,310
+ناقص bond 1 2 5 خدنا
+
+534
+01:02:56,310 --> 01:03:00,470
+نعمل ال interpolation نعطيك المعادلة العامة Y
+
+535
+01:03:00,470 --> 01:03:12,630
+بيساوي Y واحد زاد X minus X واحد على X2 minus X
+
+536
+01:03:12,630 --> 01:03:19,640
+واحد في Y2 minus Y واحدو الاصل بتاع ال
+
+537
+01:03:19,640 --> 01:03:24,660
+interpolation جاي انا عندي بيكون curve عندي هي
+
+538
+01:03:24,660 --> 01:03:33,020
+النقطة هين هي X وهي Y هين عندي X واحد وهين Y واحد
+
+539
+01:03:33,020 --> 01:03:39,700
+هي النقطة X اتنين وهين Y اتنين بحاول اعمل
+
+540
+01:03:39,700 --> 01:03:43,680
+approximation لل curve بين نقطتين ك linear هذه
+
+541
+01:03:43,680 --> 01:03:46,620
+النقطة هتكون X وY
+
+542
+01:03:48,770 --> 01:03:55,690
+السلوك بتاع الخطها ده هكون y2-x2 على y1-x1 بيستوي
+
+543
+01:03:55,690 --> 01:04:03,750
+y-y1 على x-x1 و بعدين تعمل شغل جبر و بتحسب تحكي ال
+
+544
+01:04:03,750 --> 01:04:09,710
+y اللي الكمة اللي في النص بيستوي y1 زاد x-x1 على
+
+545
+01:04:09,710 --> 01:04:16,790
+y2-y1 على x2-x1 طيب based on this equation هتكون
+
+546
+01:04:16,790 --> 01:04:25,980
+ال aعندى تسعة من عشرة بتساوي الى Y1 بونت تمانية
+
+547
+01:04:25,980 --> 01:04:32,540
+اتنين زاد بونت واحد اربعة تلاتة minus بونت واحد
+
+548
+01:04:32,540 --> 01:04:40,180
+اتنين خمسة علىاكس اتنين اللي هي point واحد خمسة
+
+549
+01:04:40,180 --> 01:04:46,220
+ماقص point واحد اتنين خمسة في y اتنين اللي هي
+
+550
+01:04:46,220 --> 01:04:55,580
+point سبعة تسعة minus point تمانية اتنين يعني عند
+
+551
+01:04:55,580 --> 01:05:01,580
+تسعة و عشرة و ال a عند ستة من عشرة تنحسب اللي هي
+
+552
+01:05:01,580 --> 01:05:12,150
+هتكونبونت تمانية اتنين على
+
+553
+01:05:12,150 --> 01:05:20,130
+اي حال ال a هتكون لحظة
+
+554
+01:05:20,130 --> 01:05:24,970
+ال a لا تتغير بين البونت تسعة و البونت ستة هتكون
+
+555
+01:05:24,970 --> 01:05:31,290
+نفسها عند البونت تمانية ال KT
+
+556
+01:05:33,260 --> 01:05:39,840
+عند التسعة من عشرة بتساوي اتنين point اربعة واحد
+
+557
+01:05:39,840 --> 01:05:47,100
+اتنين point اربعة واحد زائد point واحد اربعة تلاتة
+
+558
+01:05:47,100 --> 01:05:52,500
+ناقص point واحد اتنين خمسة على point واحد خمسة
+
+559
+01:05:52,500 --> 01:05:58,120
+ناقص point واحد اتنين خمسة في عند التسعة من عشرة
+
+560
+01:05:58,120 --> 01:06:05,040
+اللي هي اتنين point تلاتة تسعة-2.41 وهي بنحسبها و
+
+561
+01:06:05,040 --> 01:06:14,020
+ال KT عند ال 6 من 10 بتطلع
+
+562
+01:06:15,660 --> 01:06:20,120
+اللي هي اتنين point تلاتة اتنين اتنين point تلاتة
+
+563
+01:06:20,120 --> 01:06:25,180
+اتنين زاد point واحد اربعة تلاتة minus point واحد
+
+564
+01:06:25,180 --> 01:06:31,380
+اتنين خمسة على point واحد خمسة minus point واحد
+
+565
+01:06:31,380 --> 01:06:38,680
+اتنين خمسة في اللي هي اتنين point اتنين تسعة minus
+
+566
+01:06:38,680 --> 01:06:45,630
+اتنين point تلاتة اتنين من اتوا حسبنا ال Aالـ A
+
+567
+01:06:45,630 --> 01:07:09,110
+اللي هي عند ال point واحد نحسبها طيب
+
+568
+01:07:09,110 --> 01:07:14,090
+عشان اخش عسلت نحسب يعني انا صار عندهين قيمةوعندي
+
+569
+01:07:14,090 --> 01:07:20,110
+هنا قيمة لل A وعندي ال KT عند تسعة و عشرة لها قيمة
+
+570
+01:07:20,110 --> 01:07:26,230
+وال KT عند ستة و عشرة لها أيش قيمة الآن أنا بدي ال
+
+571
+01:07:26,230 --> 01:07:30,830
+D على D اللي هي bond تمانية D على D اللي بين
+
+572
+01:07:30,830 --> 01:07:37,500
+التنتين هدول اللي هي bond تمانيةبعمل second
+
+573
+01:07:37,500 --> 01:07:44,380
+interpolation عشان أحسب ال a هنا و أحسب ال kt from
+
+574
+01:07:44,380 --> 01:07:56,180
+اللي هو second interpolation find
+
+575
+01:07:56,180 --> 01:08:00,320
+a
+
+576
+01:08:00,320 --> 01:08:15,980
+و ktهكون عندى ال A كذا و ال KT كذا طيب
+
+577
+01:08:15,980 --> 01:08:20,440
+نرجع،
+
+578
+01:08:20,440 --> 01:08:25,800
+الآن صارت أنا عارف ال A و
+
+579
+01:08:25,800 --> 01:08:30,160
+ال D capital معروف و ال D small معروفة مانعت بحسب
+
+580
+01:08:30,160 --> 01:08:38,530
+ال Z net ال Z netالـ net section modulus Z net
+
+581
+01:08:38,530 --> 01:08:50,630
+بتساوي باي في ايه على اتنين و تلاتين D capital في
+
+582
+01:08:50,630 --> 01:08:56,950
+D أُس أربعة minus D small أُس أربعة
+
+583
+01:09:05,970 --> 01:09:13,870
+و منها باحسب ال sigma alternating
+
+584
+01:09:13,870 --> 01:09:23,710
+A هتكون تساوي M على
+
+585
+01:09:23,710 --> 01:09:30,070
+Z net خلينا نكمل نفس الجدول
+
+586
+01:09:38,300 --> 01:09:44,280
+في الجدول مقسم جزئية جزئية bending وجزئية torsion
+
+587
+01:09:44,280 --> 01:09:50,780
+حالة ال torsion اللي هو هذا الجدول هروح احسب كمان
+
+588
+01:09:50,780 --> 01:09:57,620
+اللي هو ال Janet اللي هو ال ال ال ال polar moment
+
+589
+01:09:57,620 --> 01:10:03,720
+of inertia لل cross section Janet ده هنبروح على
+
+590
+01:10:03,720 --> 01:10:04,220
+Janet
+
+591
+01:10:07,430 --> 01:10:13,170
+بتساوي اللي هي باي في ايه في
+
+592
+01:10:13,170 --> 01:10:18,210
+دي اص اربع minus
+
+593
+01:10:18,210 --> 01:10:23,830
+دي small اص اربع على اتنين و تلاتين
+
+594
+01:10:38,050 --> 01:10:44,790
+وال tau alternating
+
+595
+01:10:44,790 --> 01:10:52,090
+nominal هتكون معطوب العلاقة اللي
+
+596
+01:10:52,090 --> 01:11:00,010
+هي T D capital على
+
+597
+01:11:00,010 --> 01:11:01,710
+2 J net
+
+598
+01:11:07,820 --> 01:11:14,180
+برضه من الجدول هذا .. من الجدول هذا انا
+
+599
+01:11:14,180 --> 01:11:25,420
+a على d انا
+
+600
+01:11:25,420 --> 01:11:26,520
+هكون في المنطقة هذه
+
+601
+01:11:37,710 --> 01:11:42,270
+أنا عند ال هي دي small على دي capital تمام من عشرة
+
+602
+01:11:42,270 --> 01:11:51,430
+موجودة بعمل interpolation عشان أحسب ال a هنا و
+
+603
+01:11:51,430 --> 01:11:56,130
+أحسب ال kt ال
+
+604
+01:11:56,130 --> 01:12:02,330
+a و ال kt يعني
+
+605
+01:12:02,330 --> 01:12:04,830
+مانعته بالزمن أحسب kts
+
+606
+01:12:07,790 --> 01:12:16,410
+بنحسبها من الجدول by linear interpolation طيب،
+
+607
+01:12:16,410 --> 01:12:21,370
+الآن هذه كلها parameters جيومتريكيين
+
+608
+01:12:21,370 --> 01:12:29,490
+لان صرت ان عارف sigma AO و tau AO بتدروح للمعادلات
+
+609
+01:12:36,890 --> 01:12:57,550
+اللي هي ال Von Mises equations بدي
+
+610
+01:12:57,550 --> 01:12:58,070
+أحسب
+
+611
+01:13:09,950 --> 01:13:14,610
+Sigma prime alternating وSigma prime mean احنا في
+
+612
+01:13:14,610 --> 01:13:18,790
+الحالة هذه الـSigma prime mean ستكون صفر حتى عند
+
+613
+01:13:18,790 --> 01:13:21,550
+الـSigma prime alternating الـSigma prime
+
+614
+01:13:21,550 --> 01:13:26,000
+alternating ستكون كف لل bendingفى sigma a للـ
+
+615
+01:13:26,000 --> 01:13:30,040
+bending زي كف اكسل فى sigma a اكسل على point eight
+
+616
+01:13:30,040 --> 01:13:34,080
+five زي تلتة فى KFS torsion فى tau alternating
+
+617
+01:13:34,080 --> 01:13:39,560
+torsion كل تربيع قص نص احنا مش انه axial load انه
+
+618
+01:13:39,560 --> 01:13:45,920
+بس bending معناه هتكون عنده sigma
+
+619
+01:13:45,920 --> 01:13:49,700
+alternating
+
+620
+01:13:49,700 --> 01:13:58,100
+von Mises هتكون KFالـ Sigma alternating nominal
+
+621
+01:13:58,100 --> 01:14:12,700
+لكل تربيع زائد تلاتة في KFS torsion في Tau
+
+622
+01:14:12,700 --> 01:14:18,620
+alternating nominal لكل تربيع كل هذا أص نص
+
+623
+01:14:24,090 --> 01:14:31,990
+طيب احنا روديا حسبنا sigma a nominal و حسبنا tau a
+
+624
+01:14:31,990 --> 01:14:40,890
+nominal ضايل احسب KF و KFS الـ KF بالساوية
+
+625
+01:14:40,890 --> 01:14:51,930
+واحد زاد Q في KT minus واحدالـ KT already حسبتها
+
+626
+01:14:51,930 --> 01:14:58,570
+ضايق الأحسب الـ Q الـ Q من شكل ست عشرين شكل ست
+
+627
+01:14:58,570 --> 01:15:07,610
+عشرين هذا
+
+628
+01:15:07,610 --> 01:15:12,670
+الشكل الـ
+
+629
+01:15:12,670 --> 01:15:16,890
+Notch عنده يعني
+
+630
+01:15:16,890 --> 01:15:21,300
+أكبر الأربعة منه ال wholeو ال SUT ال SUT اين
+
+631
+01:15:21,300 --> 01:15:26,980
+هطلعها ماطينة هو الف و تمانتاش cold drone steel
+
+632
+01:15:26,980 --> 01:15:32,240
+المعنى ان انا هروح على جدول A20 في الكتاب انا هروح
+
+633
+01:15:32,240 --> 01:15:40,540
+على جدول A20 هذا
+
+634
+01:15:40,540 --> 01:15:47,520
+A20 انا عند cold drone الف و تمانتاش
+
+635
+01:15:50,440 --> 01:15:57,660
+هيو الف و طبنتاش call the drone هاي
+
+636
+01:15:57,660 --> 01:16:06,320
+الف و طبنتاش معناته هذا الحديد هذا ال S U T و ال S
+
+637
+01:16:06,320 --> 01:16:15,680
+Y ال من table A20 بتكون
+
+638
+01:16:15,680 --> 01:16:22,910
+عند ال S U T عشان متساوياربعمية و اربعين ميجا
+
+639
+01:16:22,910 --> 01:16:36,370
+باسكال و ال S Y بتساوي تلتمية و سبعين ميجا
+
+640
+01:16:36,370 --> 01:16:46,370
+باسكال هذا ايش ال S U T و ال S Y بروح هرجع على
+
+641
+01:16:46,370 --> 01:16:50,010
+الشكل سبعة عشرين هي ستة عشرين
+
+642
+01:16:56,490 --> 01:17:03,330
+اللي هو ده
+
+643
+01:17:03,330 --> 01:17:21,530
+ال
+
+644
+01:17:21,530 --> 01:17:22,090
+SUT
+
+645
+01:17:25,770 --> 01:17:30,970
+اللي هي أربعمية و أربعين يعني تقريبا هنا يعني
+
+646
+01:17:30,970 --> 01:17:34,130
+تقريبا تطلع ال .. ال .. ال .. ال Q تمانية من عشرة
+
+647
+01:17:34,130 --> 01:17:45,850
+ال Q هتكون ال Q تمانية من عشرة من figure ستة عشرين
+
+648
+01:17:45,850 --> 01:17:54,920
+و منها بحسب ال KF ال KFSبس واحد زاد QS في KTS
+
+649
+01:17:54,920 --> 01:18:00,240
+minus واحد و QS من figure ستة واحد و عشرين الشكل
+
+650
+01:18:00,240 --> 01:18:00,820
+اللي بعده
+
+651
+01:18:16,460 --> 01:18:20,300
+يعني point تمانية point تسعة يعني تقريبا point
+
+652
+01:18:20,300 --> 01:18:26,600
+تمانية تلاتة point تمانية تلاتة
+
+653
+01:18:26,600 --> 01:18:29,560
+figure ستة واحد وعشرين
+
+654
+01:18:34,890 --> 01:18:40,370
+الان احنا سرنا KT معروف عنها و Q طلعناها و KTS
+
+655
+01:18:40,370 --> 01:18:44,690
+معروف عنها و QS طلعناها بحث في ال KF و KFS بعدين
+
+656
+01:18:44,690 --> 01:18:48,830
+بعودة بحث في sigma prime alternating في المعادلة
+
+657
+01:18:48,830 --> 01:18:58,330
+هذه بحث في sigma prime alternating طيب
+
+658
+01:19:04,840 --> 01:19:09,060
+لأنهم بدوا ال factor of safety باستخدام gerber
+
+659
+01:19:09,060 --> 01:19:25,900
+criterion gerber criterion نرجع ال
+
+660
+01:19:25,900 --> 01:19:33,620
+gerber criterion هي ال gerber جاية
+
+661
+01:19:33,620 --> 01:19:34,360
+nonlinear
+
+662
+01:19:36,740 --> 01:19:56,320
+and sigma a and
+
+663
+01:19:56,320 --> 01:19:59,380
+sigma
+
+664
+01:19:59,380 --> 01:20:11,220
+alternating الـ primeعلى SE بالزايد N Sigma M
+
+665
+01:20:11,220 --> 01:20:21,680
+Prime على SUT الكل تربية بالساوية واحد عند هذا ال
+
+666
+01:20:21,680 --> 01:20:28,160
+term مش بيساوي سفر مانا بتحسر عندي N Sigma A Prime
+
+667
+01:20:28,160 --> 01:20:34,880
+على SEبالساوية واحد معناته الان هيكون الساوية SE
+
+668
+01:20:34,880 --> 01:20:52,360
+على Sigma A Prime طيب
+
+669
+01:20:55,530 --> 01:21:00,370
+هذا ال fact of state guarding against yield نروح
+
+670
+01:21:00,370 --> 01:21:05,730
+هنا للجداول هذا الجدول ل Godman هذا الجدول ل
+
+671
+01:21:05,730 --> 01:21:11,070
+Gerber ان حكينا الجدول هذا موجود لنقطة تقاطع هاي
+
+672
+01:21:11,070 --> 01:21:19,470
+ال Gerber S
+
+673
+01:21:19,470 --> 01:21:29,400
+U T و S Eوهي عندي sy
+
+674
+01:21:29,400 --> 01:21:37,540
+وهي ال load line السطر
+
+675
+01:21:37,540 --> 01:21:40,560
+هذا بوجد ليه نقطة تقاطع بين هذا ال load line و
+
+676
+01:21:40,560 --> 01:21:48,040
+gerber line بوجد ليه SM و SA السطر اللي بعده بوجد
+
+677
+01:21:48,040 --> 01:21:50,960
+ليه نقطة تقاطع نقطة تقاطع
+
+678
+01:21:55,160 --> 01:21:58,740
+هنا حكينا احنا .. احنا فش .. هتكون نقطتنا هنا،
+
+679
+01:21:58,740 --> 01:22:03,940
+معناه نقطتنا هنا هيكون عندي ال .. هذا ال N F طبعا
+
+680
+01:22:03,940 --> 01:22:08,660
+ال N Y هيكون
+
+681
+01:22:08,660 --> 01:22:18,520
+S Y على Sigma A Prime
+
+682
+01:22:22,870 --> 01:22:27,410
+واضح هيكون ال ny أكبر من ال nf معناته من المتوقع
+
+683
+01:22:27,410 --> 01:22:31,630
+انه يصير failure by fatigue قبل ما يصير failure by
+
+684
+01:22:31,630 --> 01:22:40,330
+yielding هذا المطلوب الأول المطلوب التاني نرجع
+
+685
+01:22:45,670 --> 01:22:48,670
+The shaft is subjected to a pulsating torque
+
+686
+01:22:48,670 --> 01:22:52,410
+fluctuating from twenty لمية وستين نيوتر متر and a
+
+687
+01:22:52,410 --> 01:22:59,090
+steady bending moment case two الحالة
+
+688
+01:22:59,090 --> 01:23:04,490
+التانية الحالة
+
+689
+01:23:04,490 --> 01:23:12,150
+التانية الشافت متعرض ل torque بتغير ال torque
+
+690
+01:23:12,150 --> 01:23:25,220
+minimumالـ T minimum بتساوي عشرين نيوتن متر وال T
+
+691
+01:23:25,220 --> 01:23:35,360
+maximum بتساوي مية و ستين نيوتن متر وال bending
+
+692
+01:23:35,360 --> 01:23:46,560
+moment is steady يعني ال Mبساوة M main بالساوية
+
+693
+01:23:46,560 --> 01:23:51,940
+150 نيوتن متر معناه في الحالة هذه هيكون عندي ال
+
+694
+01:23:51,940 --> 01:23:58,740
+tau main هيكون عشرين زي المية وستين على اتنين يعني
+
+695
+01:23:58,740 --> 01:24:05,720
+تسعين نيوتن مترالـ T alternating سواء مية و ستين
+
+696
+01:24:05,720 --> 01:24:15,220
+ناقص عشرين على اتنين سبعين نيوتن متر وال M mean
+
+697
+01:24:15,220 --> 01:24:21,660
+سواء مية و خمسين نيوتن متر وال M alternating
+
+698
+01:24:21,660 --> 01:24:31,680
+بالساوية سفر I follow the same procedureهحسب sigma
+
+699
+01:24:31,680 --> 01:24:42,340
+prime alternating نرجع للمعادلات اللي
+
+700
+01:24:42,340 --> 01:24:48,840
+هي KF لل bending طبعا
+
+701
+01:24:48,840 --> 01:24:54,000
+انا في الحالة هذه هتكون هذه صفر صفر هتكون تساوي
+
+702
+01:24:54,000 --> 01:24:57,040
+تلاتة
+
+703
+01:25:00,360 --> 01:25:13,800
+كفاس في tau alternating nominal الكل تربيع كله
+
+704
+01:25:13,800 --> 01:25:23,380
+تحت الجدر و ال sigma prime main هتكون ساوى كف
+
+705
+01:25:23,380 --> 01:25:26,620
+sigma
+
+706
+01:25:26,620 --> 01:25:37,700
+mainنومينال كل تربيع زائد تلاتة في KFS تاومين
+
+707
+01:25:37,700 --> 01:25:43,540
+نومينال كل تربيع الكل اص نص يعني انا عندي هكون
+
+708
+01:25:43,540 --> 01:25:47,600
+عندي sigma alternating born mice sigma prime born
+
+709
+01:25:47,600 --> 01:25:54,920
+mice اللي انا على فرق كتير عند هاي gear barهذه S U
+
+710
+01:25:54,920 --> 01:26:07,480
+T وهذه S E وهذه ال load ال load line هحسب
+
+711
+01:26:07,480 --> 01:26:18,720
+S M و S alternating ومنها بحسب ال N F بالساوية
+
+712
+01:26:18,720 --> 01:26:29,850
+اللي هي S Mعلى sigma M و برضه مستوى S A على sigma
+
+713
+01:26:29,850 --> 01:26:34,750
+A prime هذا
+
+714
+01:26:34,750 --> 01:26:46,470
+في حالة الفتيك في حالة ال yielding في
+
+715
+01:26:46,470 --> 01:26:47,390
+حالة ال yielding
+
+716
+01:26:50,660 --> 01:26:54,140
+بحسب ال S A بسوة R أسواع على واحة زاد R وبعدين
+
+717
+01:26:54,140 --> 01:26:59,740
+بحكي ال factor of safety N بساوة S A على Sigma A
+
+718
+01:26:59,740 --> 01:27:03,020
+Prime هيك بنكون حاليا انا طبعا السؤال طويل كتير
+
+719
+01:27:03,020 --> 01:27:08,070
+بتوقع انكوا تتابعوا الفيديو الكويسو اتحلوا المسائل
+
+720
+01:27:08,070 --> 01:27:12,070
+بالارقام طبعا هذا ال example موجود في الكتاب تقدر
+
+721
+01:27:12,070 --> 01:27:16,730
+تتبعه من الكتاب و تقارنه بين الحل اللي انا حلته و
+
+722
+01:27:16,730 --> 01:27:23,730
+حل الكتاب يعني احنا هنكون متقاربين جدا من .. من
+
+723
+01:27:23,730 --> 01:27:27,990
+بعض احنا هيك بنكون تقريبا غطينا المادة ال machine
+
+724
+01:27:27,990 --> 01:27:31,710
+design واحد حكوا ان ال course ال machine design
+
+725
+01:27:31,710 --> 01:27:34,660
+اتنيناللي هو هكون ال design of mechanical
+
+726
+01:27:34,660 --> 01:27:38,240
+components، هنحكي عن design of shafts، عن design
+
+727
+01:27:38,240 --> 01:27:42,040
+of gears، عن design of springs، عن design of
+
+728
+01:27:42,040 --> 01:27:45,020
+screws، عن design of welding، عن design of
+
+729
+01:27:45,020 --> 01:27:53,600
+sprockets، ال .. ال design of pulleys، يعني هنت ..
+
+730
+01:27:53,600 --> 01:27:56,900
+يعني هكون إشي specific for specific components، دي
+
+731
+01:27:56,900 --> 01:27:57,260
+كل عالم
+
diff --git a/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/EruFwa8nhZA_raw.json b/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/EruFwa8nhZA_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..f16c087611d705d6b8e472be925dc499d79508fd
--- /dev/null
+++ b/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/EruFwa8nhZA_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 3084, "start": 4.88, "end": 30.84, "text": "بسم الله الرحمن الرحيم السلام عليكم و رحمة الله اليوم هنكمل اللي هو fatigue failure due to dynamic loading في المحاضرات السابقة حكينا عن fatigue criteria for ductile materials اتعرفنا على ال S-endogram ال S-endogram فرضنا او حددنا مناطق finite life و infinite life", "tokens": [3555, 38251, 21984, 34892, 5016, 27842, 34892, 5016, 32640, 21136, 37440, 25894, 24793, 4032, 12602, 35571, 3660, 21984, 45595, 20498, 8032, 1863, 24793, 1211, 13672, 1829, 31439, 20574, 7763, 3462, 281, 8546, 15114, 8978, 9673, 5016, 46958, 2288, 9307, 21136, 16758, 28671, 11331, 4117, 1829, 8315, 18871, 20574, 11101, 337, 25954, 794, 5319, 1975, 2655, 3615, 28480, 8315, 15844, 2423, 318, 12, 521, 12820, 2423, 318, 12, 521, 12820, 6156, 43042, 8315, 1975, 2407, 11331, 3215, 3215, 8315, 9154, 41193, 4587, 19362, 993, 4032, 13785, 993], "avg_logprob": -0.12311422208259845, "compression_ratio": 1.6347826086956523, "no_speech_prob": 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هو", "probability": 0.9892578125}, {"start": 10.0, "end": 11.06, "word": " fatigue", "probability": 0.9365234375}, {"start": 11.06, "end": 11.56, "word": " failure", "probability": 0.91162109375}, {"start": 11.56, "end": 11.94, "word": " due", "probability": 0.9580078125}, {"start": 11.94, "end": 12.18, "word": " to", "probability": 0.96826171875}, {"start": 12.18, "end": 12.62, "word": " dynamic", "probability": 0.78564453125}, {"start": 12.62, "end": 13.18, "word": " loading", "probability": 0.93994140625}, {"start": 13.18, "end": 14.26, "word": " في", "probability": 0.77685546875}, {"start": 14.26, "end": 14.9, "word": " المحاضرات", "probability": 0.960546875}, {"start": 14.9, "end": 15.34, "word": " السابقة", "probability": 0.9908854166666666}, {"start": 15.34, "end": 15.7, "word": " حكينا", "probability": 0.9830322265625}, {"start": 15.7, "end": 15.86, "word": " عن", "probability": 0.90576171875}, {"start": 15.86, "end": 16.24, "word": " fatigue", "probability": 0.6357421875}, {"start": 16.24, "end": 17.58, "word": " criteria", "probability": 0.67822265625}, {"start": 17.58, "end": 17.88, "word": " for", "probability": 0.97412109375}, {"start": 17.88, "end": 18.58, "word": " ductile", "probability": 0.7237548828125}, {"start": 18.58, "end": 19.64, "word": " materials", "probability": 0.80419921875}, {"start": 19.64, "end": 21.82, "word": " اتعرفنا", "probability": 0.916796875}, {"start": 21.82, "end": 22.0, "word": " على", "probability": 0.818359375}, {"start": 22.0, "end": 22.1, "word": " ال", "probability": 0.93017578125}, {"start": 22.1, "end": 22.28, "word": " S", "probability": 0.4541015625}, {"start": 22.28, "end": 22.98, "word": "-endogram", "probability": 0.6577962239583334}, {"start": 22.98, "end": 23.3, "word": " ال", "probability": 0.45458984375}, {"start": 23.3, "end": 23.46, "word": " S", "probability": 0.9755859375}, {"start": 23.46, "end": 24.0, "word": "-endogram", "probability": 0.9646809895833334}, {"start": 24.0, "end": 26.18, "word": " 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0.91748046875}, {"start": 282.04, "end": 282.4, "word": " الحالة", "probability": 0.9674479166666666}, {"start": 282.4, "end": 282.68, "word": " هذه", "probability": 0.86669921875}], "temperature": 1.0}, {"id": 11, "seek": 31320, "start": 284.07, "end": 313.21, "text": "S A على S E بالساوية واحد minus S M على S U T على واحد زائد S M على S U T طبعا هذا ال loading line بتاعنا هذا ال load line ان هي اللي هتكون ال sigma M", "tokens": [50, 316, 15844, 318, 462, 20666, 3794, 995, 2407, 10632, 36764, 24401, 3175, 318, 376, 15844, 318, 624, 314, 15844, 36764, 24401, 30767, 16373, 3215, 318, 376, 15844, 318, 624, 314, 23032, 3555, 3615, 995, 23758, 2423, 15114, 1622, 39894, 45761, 8315, 23758, 2423, 3677, 1622, 16472, 39896, 13672, 1829, 8032, 2655, 30544, 2423, 12771, 376], "avg_logprob": -0.22683662489840858, "compression_ratio": 1.4863013698630136, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 284.07, "end": 284.49, "word": "S", "probability": 0.261962890625}, {"start": 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loading", "probability": 0.88330078125}, {"start": 302.49, "end": 302.79, "word": " line", "probability": 0.9677734375}, {"start": 302.79, "end": 303.45, "word": " بتاعنا", "probability": 0.92578125}, {"start": 303.45, "end": 305.89, "word": " هذا", "probability": 0.89208984375}, {"start": 305.89, "end": 306.05, "word": " ال", "probability": 0.96728515625}, {"start": 306.05, "end": 306.33, "word": " load", "probability": 0.51513671875}, {"start": 306.33, "end": 308.59, "word": " line", "probability": 0.96240234375}, {"start": 308.59, "end": 309.85, "word": " ان", "probability": 0.487548828125}, {"start": 309.85, "end": 309.99, "word": " هي", "probability": 0.6044921875}, {"start": 309.99, "end": 310.07, "word": " اللي", "probability": 0.945068359375}, {"start": 310.07, "end": 310.51, "word": " هتكون", "probability": 0.94970703125}, {"start": 310.51, "end": 312.61, "word": " ال", "probability": 0.401123046875}, {"start": 312.61, "end": 312.87, "word": " sigma", "probability": 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0.98291015625}, {"start": 327.4, "end": 327.68, "word": " احنا", "probability": 0.7596842447916666}, {"start": 327.68, "end": 327.96, "word": " كنا", "probability": 0.97265625}, {"start": 327.96, "end": 328.46, "word": " واقعين", "probability": 0.9552001953125}, {"start": 328.46, "end": 328.7, "word": " على", "probability": 0.796875}, {"start": 328.7, "end": 328.86, "word": " ال", "probability": 0.47314453125}, {"start": 328.86, "end": 329.16, "word": " filler", "probability": 0.8505859375}, {"start": 329.16, "end": 329.64, "word": " line", "probability": 0.9599609375}, {"start": 329.64, "end": 332.3, "word": " لكن", "probability": 0.9326171875}, {"start": 332.3, "end": 332.54, "word": " لو", "probability": 0.97900390625}, {"start": 332.54, "end": 332.94, "word": " حطينا", "probability": 0.88916015625}, {"start": 332.94, "end": 333.28, "word": " factor", "probability": 0.86279296875}, {"start": 333.28, "end": 333.46, "word": " of", "probability": 0.9599609375}, {"start": 333.46, "end": 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1306.66, "text": "لو هيكون a خمستاش واحد ليها دي بلزمنا d على w دي هيكون ان دي a خمستاش واحد بدي احسب d على w دي اللي هي ربع على ال w", "tokens": [1211, 2407, 39896, 30544, 257, 16490, 2304, 14851, 33599, 36764, 24401, 32239, 11296, 11778, 1829, 4724, 1211, 11622, 2304, 8315, 274, 15844, 261, 11778, 1829, 39896, 30544, 16472, 11778, 1829, 257, 16490, 2304, 14851, 33599, 36764, 24401, 4724, 16254, 1975, 5016, 35457, 274, 15844, 261, 11778, 1829, 13672, 1829, 39896, 12602, 3555, 3615, 15844, 2423, 261], "avg_logprob": -0.3125000083655642, "compression_ratio": 1.7168141592920354, "no_speech_prob": 0.0, "words": [{"start": 1278.18, "end": 1278.46, "word": "لو", "probability": 0.6910400390625}, {"start": 1278.46, "end": 1278.78, "word": " هيكون", "probability": 0.631103515625}, {"start": 1278.78, "end": 1278.96, "word": " a", "probability": 0.3759765625}, {"start": 1278.96, "end": 1279.56, "word": " خمستاش", "probability": 0.7484130859375}, {"start": 1279.56, "end": 1280.0, "word": " واحد", 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"probability": 0.78125}, {"start": 1349.93, "end": 1350.19, "word": " keto", "probability": 0.170166015625}, {"start": 1350.19, "end": 1350.47, "word": " طلعت", "probability": 0.8971354166666666}, {"start": 1350.47, "end": 1350.69, "word": " nine", "probability": 0.18212890625}, {"start": 1350.69, "end": 1351.07, "word": " point", "probability": 0.98095703125}, {"start": 1351.07, "end": 1351.65, "word": " اربعة", "probability": 0.8463541666666666}, {"start": 1351.65, "end": 1352.59, "word": " خمسة", "probability": 0.9930419921875}], "temperature": 1.0}, {"id": 47, "seek": 139301, "start": 1388.17, "end": 1393.01, "text": "طيب معناته استخدمنا ال table A 15 واحد عشان اطلع ال stress concentration factor", "tokens": [9566, 1829, 3555, 20449, 8315, 47395, 44713, 9778, 40448, 8315, 2423, 3199, 316, 2119, 36764, 24401, 6225, 8592, 7649, 1975, 9566, 1211, 3615, 2423, 4244, 9856, 5952], "avg_logprob": -0.26130021789244245, "compression_ratio": 1.018181818181818, "no_speech_prob": 0.0, "words": 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"end": 1444.7, "word": " point", "probability": 0.442626953125}, {"start": 1444.7, "end": 1445.18, "word": " خمسة", "probability": 0.961669921875}, {"start": 1445.18, "end": 1445.7, "word": " خمسة", "probability": 0.9366455078125}, {"start": 1445.7, "end": 1446.34, "word": " ستة", "probability": 0.9763997395833334}], "temperature": 1.0}, {"id": 49, "seek": 148324, "start": 1471.6, "end": 1483.24, "text": "طيب ال .. ال .. ال cast iron ال cast iron is not sensitive", "tokens": [9566, 1829, 3555, 2423, 4386, 2423, 4386, 2423, 4193, 6497, 2423, 4193, 6497, 307, 406, 9477], "avg_logprob": -0.19140625, "compression_ratio": 1.3529411764705883, "no_speech_prob": 0.0, "words": [{"start": 1471.6000000000001, "end": 1472.44, "word": "طيب", "probability": 0.9772135416666666}, {"start": 1472.44, "end": 1473.28, "word": " ال", "probability": 0.9423828125}, {"start": 1473.28, "end": 1473.38, "word": " ..", "probability": 0.476806640625}, {"start": 1473.38, "end": 1473.64, "word": " ال", "probability": 0.923828125}, {"start": 1473.64, "end": 1473.64, "word": " ..", "probability": 0.845703125}, {"start": 1473.64, "end": 1473.9, "word": " ال", "probability": 0.94775390625}, {"start": 1473.9, "end": 1474.28, "word": " cast", "probability": 0.74169921875}, {"start": 1474.28, "end": 1474.76, "word": " iron", "probability": 0.90234375}, {"start": 1474.76, "end": 1475.0, "word": " ال", "probability": 0.29443359375}, {"start": 1475.0, "end": 1475.28, "word": " cast", "probability": 0.82080078125}, {"start": 1475.28, "end": 1475.7, "word": " iron", "probability": 0.9404296875}, {"start": 1475.7, "end": 1480.74, "word": " is", "probability": 0.92822265625}, {"start": 1480.74, "end": 1481.38, "word": " not", "probability": 0.97412109375}, {"start": 1481.38, "end": 1483.24, "word": " sensitive", "probability": 0.9150390625}], "temperature": 1.0}, {"id": 50, "seek": 150867, "start": 1485.83, "end": 1508.67, "text": "to notches في حالة in case of static loading يعني ممكن احكي الان في الحالة هذه", "tokens": [1353, 406, 3781, 8978, 11331, 6027, 3660, 294, 1389, 295, 13437, 15114, 37495, 22653, 3714, 43020, 1975, 5016, 4117, 1829, 2423, 7649, 8978, 21542, 6027, 3660, 29538], "avg_logprob": -0.14285714392151153, "compression_ratio": 1.1326530612244898, "no_speech_prob": 0.0, "words": [{"start": 1485.83, "end": 1486.13, "word": "to", "probability": 0.52978515625}, {"start": 1486.13, "end": 1486.91, "word": " notches", "probability": 0.947509765625}, {"start": 1486.91, "end": 1489.53, "word": " في", "probability": 0.66259765625}, {"start": 1489.53, "end": 1489.99, "word": " حالة", "probability": 0.9964192708333334}, {"start": 1489.99, "end": 1490.21, "word": " in", "probability": 0.5703125}, {"start": 1490.21, "end": 1490.71, "word": " case", "probability": 0.8623046875}, {"start": 1490.71, "end": 1493.07, "word": " of", "probability": 0.96630859375}, {"start": 1493.07, "end": 1493.73, "word": " static", "probability": 0.96142578125}, {"start": 1493.73, "end": 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0.96484375}, {"start": 2859.91, "end": 2860.59, "word": " alternating", "probability": 0.9111328125}, {"start": 2860.59, "end": 2860.93, "word": " von", "probability": 0.98486328125}, {"start": 2860.93, "end": 2861.33, "word": " Mises", "probability": 0.959228515625}, {"start": 2861.33, "end": 2862.09, "word": " او", "probability": 0.7464599609375}, {"start": 2862.09, "end": 2862.35, "word": " mid", "probability": 0.9501953125}, {"start": 2862.35, "end": 2862.71, "word": " range", "probability": 0.50830078125}, {"start": 2862.71, "end": 2863.07, "word": " von", "probability": 0.9853515625}, {"start": 2863.07, "end": 2863.39, "word": " Mises", "probability": 0.96728515625}], "temperature": 1.0}, {"id": 96, "seek": 287810, "start": 2866.76, "end": 2878.1, "text": "then we apply KF to each type of stress في حالة ال load factor use KC جوه المعادلة", "tokens": [19096, 321, 3079, 591, 37, 281, 1184, 2010, 295, 4244, 8978, 11331, 6027, 3660, 2423, 3677, 5952, 764, 591, 34, 10874, 2407, 3224, 9673, 3615, 18513, 37977], "avg_logprob": -0.24497769240822112, "compression_ratio": 1.0, "no_speech_prob": 0.0, "words": [{"start": 2866.76, "end": 2867.18, "word": "then", "probability": 0.46923828125}, {"start": 2867.18, "end": 2867.4, "word": " we", "probability": 0.9365234375}, {"start": 2867.4, "end": 2867.96, "word": " apply", "probability": 0.94580078125}, {"start": 2867.96, "end": 2869.3, "word": " KF", "probability": 0.7177734375}, {"start": 2869.3, "end": 2869.5, "word": " to", "probability": 0.9521484375}, {"start": 2869.5, "end": 2869.8, "word": " each", "probability": 0.95849609375}, {"start": 2869.8, "end": 2870.32, "word": " type", "probability": 0.9560546875}, {"start": 2870.32, "end": 2871.06, "word": " of", "probability": 0.97607421875}, {"start": 2871.06, "end": 2871.7, "word": " stress", "probability": 0.9462890625}, {"start": 2871.7, "end": 2873.76, "word": " في", "probability": 0.6123046875}, {"start": 2873.76, "end": 2874.16, "word": " حالة", "probability": 0.9951171875}, {"start": 2874.16, "end": 2874.32, "word": " ال", "probability": 0.56982421875}, {"start": 2874.32, "end": 2874.58, "word": " load", "probability": 0.8740234375}, {"start": 2874.58, "end": 2875.2, "word": " factor", "probability": 0.90234375}, {"start": 2875.2, "end": 2876.64, "word": " use", "probability": 0.61328125}, {"start": 2876.64, "end": 2877.22, "word": " KC", "probability": 0.85400390625}, {"start": 2877.22, "end": 2877.6, "word": " جوه", "probability": 0.7534993489583334}, {"start": 2877.6, "end": 2878.1, "word": " المعادلة", "probability": 0.9478759765625}], "temperature": 1.0}, {"id": 97, "seek": 290353, "start": 2881.73, "end": 2903.53, "text": "The torsion load factor Kc equal point five nine is inherently included in the von Mises equations سنستخدم المعادلات التالية sigma prime A هي von Mises alternating وعندي معادلة sigma prime M هي von Mises mean طبعا تفاصيلها بتساوي Kf due to bending", "tokens": [2278, 3930, 82, 313, 3677, 5952, 591, 66, 2681, 935, 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سنستخدم", "probability": 0.78935546875}, {"start": 2889.59, "end": 2890.29, "word": " المعادلات", "probability": 0.964453125}, {"start": 2890.29, "end": 2891.11, "word": " التالية", "probability": 0.98681640625}, {"start": 2891.11, "end": 2892.01, "word": " sigma", "probability": 0.2437744140625}, {"start": 2892.01, "end": 2892.63, "word": " prime", "probability": 0.74365234375}, {"start": 2892.63, "end": 2892.91, "word": " A", "probability": 0.412353515625}, {"start": 2892.91, "end": 2893.17, "word": " هي", "probability": 0.07415771484375}, {"start": 2893.17, "end": 2893.55, "word": " von", "probability": 0.31298828125}, {"start": 2893.55, "end": 2893.85, "word": " Mises", "probability": 0.92822265625}, {"start": 2893.85, "end": 2894.51, "word": " alternating", "probability": 0.9345703125}, {"start": 2894.51, "end": 2895.01, "word": " وعندي", "probability": 0.755126953125}, {"start": 2895.01, "end": 2895.43, "word": " معادلة", "probability": 0.9847005208333334}, {"start": 2895.43, "end": 2895.67, "word": " sigma", "probability": 0.84619140625}, {"start": 2895.67, "end": 2895.97, "word": " prime", "probability": 0.69677734375}, {"start": 2895.97, "end": 2896.11, "word": " M", "probability": 0.93896484375}, {"start": 2896.11, "end": 2896.29, "word": " هي", "probability": 0.77587890625}, {"start": 2896.29, "end": 2896.55, "word": " von", "probability": 0.716796875}, {"start": 2896.55, "end": 2897.01, "word": " Mises", "probability": 0.958984375}, {"start": 2897.01, "end": 2897.69, "word": " mean", "probability": 0.88427734375}, {"start": 2897.69, "end": 2898.95, "word": " طبعا", "probability": 0.62811279296875}, {"start": 2898.95, "end": 2899.93, "word": " تفاصيلها", "probability": 0.91845703125}, {"start": 2899.93, "end": 2900.77, "word": " بتساوي", "probability": 0.6575927734375}, {"start": 2900.77, "end": 2901.49, "word": " Kf", "probability": 0.77587890625}, {"start": 2901.49, "end": 2902.93, "word": " due", "probability": 0.82275390625}, {"start": 2902.93, "end": 2903.13, "word": " to", "probability": 0.96923828125}, {"start": 2903.13, "end": 2903.53, "word": " bending", "probability": 0.81982421875}], "temperature": 1.0}, {"id": 98, "seek": 293171, "start": 2904.27, "end": 2931.71, "text": "في sigma alternating due to bending زاد كف كف due to axial loading في sigma alternating due to axial loading على point eight five الكل تربية يعني ال course ده بيحتوي كل ال normal stress due to bending و due to axial loading لاحظ ال stress concentration effect is included for both bending and for both axial loading", "tokens": [41185, 12771, 40062, 3462, 281, 22487, 30767, 18513, 9122, 5172, 9122, 5172, 3462, 281, 46851, 15114, 8978, 12771, 40062, 3462, 281, 46851, 15114, 15844, 935, 3180, 1732, 2423, 28820, 6055, 25513, 10632, 37495, 22653, 2423, 1164, 11778, 3224, 4724, 1829, 33753, 45865, 28242, 2423, 2710, 4244, 3462, 281, 22487, 4032, 3462, 281, 46851, 15114, 20193, 5016, 19913, 2423, 4244, 9856, 1802, 307, 5556, 337, 1293, 22487, 293, 337, 1293, 46851, 15114], "avg_logprob": -0.1852213539597061, "compression_ratio": 1.7794117647058822, "no_speech_prob": 0.0, "words": [{"start": 2904.27, "end": 2904.47, "word": "في", "probability": 0.46435546875}, {"start": 2904.47, "end": 2904.77, "word": " sigma", "probability": 0.6591796875}, {"start": 2904.77, "end": 2905.37, "word": " alternating", "probability": 0.95654296875}, {"start": 2905.37, "end": 2905.71, "word": " due", "probability": 0.94580078125}, {"start": 2905.71, "end": 2905.89, "word": " to", "probability": 0.970703125}, {"start": 2905.89, "end": 2906.31, "word": " bending", "probability": 0.9296875}, {"start": 2906.31, "end": 2907.37, "word": " زاد", "probability": 0.450927734375}, {"start": 2907.37, "end": 2907.67, "word": " كف", "probability": 0.92529296875}, {"start": 2907.67, "end": 2908.29, "word": " كف", "probability": 0.54052734375}, {"start": 2908.29, "end": 2908.87, "word": " due", "probability": 0.912109375}, {"start": 2908.87, "end": 2909.05, "word": " to", 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"probability": 0.54736328125}, {"start": 2913.43, "end": 2913.85, "word": " five", "probability": 0.9140625}, {"start": 2913.85, "end": 2914.39, "word": " الكل", "probability": 0.682373046875}, {"start": 2914.39, "end": 2914.91, "word": " تربية", "probability": 0.7747395833333334}, {"start": 2914.91, "end": 2915.83, "word": " يعني", "probability": 0.89990234375}, {"start": 2915.83, "end": 2916.95, "word": " ال", "probability": 0.436767578125}, {"start": 2916.95, "end": 2917.23, "word": " course", "probability": 0.76708984375}, {"start": 2917.23, "end": 2917.49, "word": " ده", "probability": 0.6778564453125}, {"start": 2917.49, "end": 2917.95, "word": " بيحتوي", "probability": 0.9334716796875}, {"start": 2917.95, "end": 2918.35, "word": " كل", "probability": 0.97265625}, {"start": 2918.35, "end": 2918.61, "word": " ال", "probability": 0.82373046875}, {"start": 2918.61, "end": 2918.89, "word": " normal", "probability": 0.7607421875}, {"start": 2918.89, "end": 2919.61, "word": " stress", "probability": 0.98486328125}, {"start": 2919.61, "end": 2920.73, "word": " due", "probability": 0.94091796875}, {"start": 2920.73, "end": 2921.45, "word": " to", "probability": 0.97705078125}, {"start": 2921.45, "end": 2921.97, "word": " bending", "probability": 0.9208984375}, {"start": 2921.97, "end": 2922.89, "word": " و", "probability": 0.9560546875}, {"start": 2922.89, "end": 2923.09, "word": " due", "probability": 0.8466796875}, {"start": 2923.09, "end": 2923.37, "word": " to", "probability": 0.97802734375}, {"start": 2923.37, "end": 2923.91, "word": " axial", "probability": 0.94873046875}, {"start": 2923.91, "end": 2924.65, "word": " loading", "probability": 0.923828125}, {"start": 2924.65, "end": 2925.73, "word": " لاحظ", "probability": 0.9065755208333334}, {"start": 2925.73, "end": 2925.91, "word": " ال", "probability": 0.9365234375}, {"start": 2925.91, "end": 2926.23, "word": " stress", "probability": 0.9755859375}, {"start": 2926.23, "end": 2926.75, "word": " concentration", "probability": 0.9287109375}, {"start": 2926.75, "end": 2927.17, "word": " effect", "probability": 0.95556640625}, {"start": 2927.17, "end": 2927.35, "word": " is", "probability": 0.953125}, {"start": 2927.35, "end": 2927.81, "word": " included", "probability": 0.8662109375}, {"start": 2927.81, "end": 2928.19, "word": " for", "probability": 0.96435546875}, {"start": 2928.19, "end": 2928.59, "word": " both", "probability": 0.8994140625}, {"start": 2928.59, "end": 2929.13, "word": " bending", "probability": 0.888671875}, {"start": 2929.13, "end": 2929.77, "word": " and", "probability": 0.8818359375}, {"start": 2929.77, "end": 2930.05, "word": " for", "probability": 0.6162109375}, {"start": 2930.05, "end": 2930.39, "word": " both", "probability": 0.88916015625}, {"start": 2930.39, "end": 2930.93, "word": " axial", "probability": 0.9560546875}, {"start": 2930.93, "end": 2931.71, "word": " loading", "probability": 0.92578125}], "temperature": 1.0}, {"id": 99, "seek": 295497, "start": 2937.13, "end": 2954.97, "text": "زائد تلاتة KFS اللي هو fatigue concentration factor due to torsion في tau alternating اللي هو alternating shear stress component لكل تربيع قص نص نفس المعادلة في حالة", "tokens": [11622, 16373, 3215, 6055, 1211, 9307, 3660, 591, 29318, 13672, 1829, 31439, 20574, 9856, 5952, 3462, 281, 3930, 82, 313, 8978, 17842, 40062, 13672, 1829, 31439, 40062, 24082, 4244, 6542, 5296, 28820, 6055, 2288, 21292, 3615, 12174, 9381, 8717, 9381, 8717, 36178, 9673, 3615, 18513, 37977, 8978, 11331, 6027, 3660], "avg_logprob": -0.1982230327877344, "compression_ratio": 1.3312883435582823, "no_speech_prob": 0.0, "words": [{"start": 2937.13, "end": 2937.73, "word": "زائد", "probability": 0.7516276041666666}, {"start": 2937.73, "end": 2938.29, "word": " تلاتة", "probability": 0.9346923828125}, {"start": 2938.29, "end": 2939.17, "word": " KFS", "probability": 0.689453125}, {"start": 2939.17, "end": 2940.39, "word": " اللي", "probability": 0.632568359375}, {"start": 2940.39, "end": 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diameter hole draw transverse يعني فيه hole قطر ال hole ستة millimeter", "tokens": [474, 575, 257, 2309, 17942, 14196, 5458, 2642, 1145, 4308, 37495, 22653, 8978, 3224, 5458, 12174, 9566, 2288, 2423, 5458, 8608, 2655, 3660, 17942], "avg_logprob": -0.35312499046325685, "compression_ratio": 1.134020618556701, "no_speech_prob": 0.0, "words": [{"start": 3218.8, "end": 3219.12, "word": "and", "probability": 0.744140625}, {"start": 3219.12, "end": 3219.66, "word": " has", "probability": 0.94873046875}, {"start": 3219.66, "end": 3222.18, "word": " a", "probability": 0.88427734375}, {"start": 3222.18, "end": 3222.44, "word": " six", "probability": 0.6806640625}, {"start": 3222.44, "end": 3222.94, "word": " millimeter", "probability": 0.5576171875}, {"start": 3222.94, "end": 3223.9, "word": " diameter", "probability": 0.62255859375}, {"start": 3223.9, "end": 3224.42, "word": " hole", "probability": 0.89990234375}, {"start": 3224.42, "end": 3224.74, "word": " draw", "probability": 0.259765625}, 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"word": " of", "probability": 0.955078125}, {"start": 3263.72, "end": 3264.08, "word": " safety", "probability": 0.9658203125}, {"start": 3264.08, "end": 3264.72, "word": " guarding", "probability": 0.9423828125}, {"start": 3264.72, "end": 3265.22, "word": " against", "probability": 0.91455078125}, {"start": 3265.22, "end": 3265.6, "word": " fatigue", "probability": 0.92529296875}, {"start": 3265.6, "end": 3266.04, "word": " loading", "probability": 0.91943359375}, {"start": 3266.04, "end": 3266.98, "word": " guarding", "probability": 0.7490234375}, {"start": 3266.98, "end": 3267.62, "word": " against", "probability": 0.9296875}, {"start": 3267.62, "end": 3268.76, "word": " yielding", "probability": 0.947265625}, {"start": 3268.76, "end": 3269.96, "word": " طبعا", "probability": 0.966064453125}, {"start": 3269.96, "end": 3270.12, "word": " في", "probability": 0.9072265625}, {"start": 3270.12, "end": 3270.4, "word": " حالة", "probability": 0.9890950520833334}, {"start": 3270.4, "end": 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the shaft is subjected to a completely reversed torque completely reversed torque يعني عندي ال torque minimum بالسواء ناقص مائة و عشرين نيوتر متر وال torque maximum", "tokens": [3322, 18467, 1389, 257, 264, 18467, 307, 32153, 281, 257, 2584, 30563, 16437, 2584, 30563, 16437, 37495, 22653, 18871, 16254, 2423, 16437, 7285, 20666, 3794, 2407, 16606, 8717, 995, 4587, 9381, 3714, 16373, 3660, 4032, 6225, 46309, 9957, 8717, 1829, 35473, 2288, 44650, 2288, 16070, 16437, 6674], "avg_logprob": -0.2630208457509677, "compression_ratio": 1.4966442953020134, "no_speech_prob": 0.0, "words": [{"start": 3278.34, "end": 3278.58, "word": "the", "probability": 0.317138671875}, {"start": 3278.58, "end": 3279.12, "word": " shaft", "probability": 0.9306640625}, {"start": 3279.12, "end": 3280.0, "word": " case", "probability": 0.79736328125}, {"start": 3280.0, "end": 3280.38, "word": " a", "probability": 0.55712890625}, {"start": 3280.38, "end": 3283.66, "word": " the", "probability": 0.47509765625}, 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{"start": 3292.8, "end": 3293.24, "word": " عندي", "probability": 0.73046875}, {"start": 3293.24, "end": 3294.4, "word": " ال", "probability": 0.94921875}, {"start": 3294.4, "end": 3294.86, "word": " torque", "probability": 0.86962890625}, {"start": 3294.86, "end": 3295.38, "word": " minimum", "probability": 0.97412109375}, {"start": 3295.38, "end": 3299.32, "word": " بالسواء", "probability": 0.598388671875}, {"start": 3299.32, "end": 3299.66, "word": " ناقص", "probability": 0.96435546875}, {"start": 3299.66, "end": 3299.9, "word": " مائة", "probability": 0.6238606770833334}, {"start": 3299.9, "end": 3299.96, "word": " و", "probability": 0.94482421875}, {"start": 3299.96, "end": 3300.28, "word": " عشرين", "probability": 0.7672526041666666}, {"start": 3300.28, "end": 3300.54, "word": " نيوتر", "probability": 0.8839111328125}, {"start": 3300.54, "end": 3300.94, "word": " متر", "probability": 0.966064453125}, {"start": 3300.94, "end": 3305.38, "word": " وال", "probability": 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"probability": 0.81689453125}, {"start": 3329.78, "end": 3329.86, "word": " و", "probability": 0.9951171875}, {"start": 3329.86, "end": 3330.3, "word": " خمسين", "probability": 0.9708251953125}, {"start": 3330.3, "end": 3331.56, "word": " نيوتن", "probability": 0.900390625}, {"start": 3331.56, "end": 3332.04, "word": " متر", "probability": 0.989501953125}, {"start": 3332.04, "end": 3333.26, "word": " وال", "probability": 0.416259765625}, {"start": 3333.26, "end": 3333.6, "word": " bending", "probability": 0.833984375}, {"start": 3333.6, "end": 3334.26, "word": " maximum", "probability": 0.9638671875}, {"start": 3334.26, "end": 3334.56, "word": " M", "probability": 0.8076171875}, {"start": 3334.56, "end": 3335.62, "word": " maximum", "probability": 0.9755859375}, {"start": 3335.62, "end": 3336.22, "word": " so", "probability": 0.3916015625}, {"start": 3336.22, "end": 3336.44, "word": " مية", "probability": 0.9453125}, {"start": 3336.44, "end": 3336.52, "word": " و", "probability": 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3594.8, "end": 3621.3, "text": "بونت تمانية واحد بونت تمانية تقريبا من الجدول هذا هحسب ال a و ال kt اللي انا عندي اللي هو a على d اللي هو بنت واحد اربعة", "tokens": [3555, 11536, 2655, 46811, 7649, 10632, 36764, 24401, 4724, 11536, 2655, 46811, 7649, 10632, 6055, 4587, 16572, 3555, 995, 9154, 25724, 3215, 12610, 23758, 8032, 5016, 35457, 2423, 257, 4032, 2423, 350, 83, 13672, 1829, 1975, 8315, 18871, 16254, 13672, 1829, 31439, 257, 15844, 274, 13672, 1829, 31439, 44945, 2655, 36764, 24401, 1975, 25513, 27884], "avg_logprob": -0.24051339764680182, "compression_ratio": 1.6774193548387097, "no_speech_prob": 0.0, "words": [{"start": 3594.8, "end": 3595.5, "word": "بونت", "probability": 0.5860188802083334}, {"start": 3595.5, "end": 3596.2, "word": " تمانية", "probability": 0.96533203125}, {"start": 3596.2, "end": 3597.88, "word": " واحد", "probability": 0.904052734375}, {"start": 3597.88, "end": 3600.2, "word": " بونت", "probability": 0.7605794270833334}, {"start": 3600.2, "end": 3600.64, 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3649.2, "text": "اللي هي هتكون في المنطقة هذه هي عندي هنا point واحد اربعة تلاتة و D small على D كبت هنا عندي تسعة من عشرة", "tokens": [6027, 20292, 39896, 8032, 2655, 30544, 8978, 9673, 1863, 9566, 28671, 29538, 39896, 18871, 16254, 34105, 935, 36764, 24401, 1975, 25513, 27884, 6055, 1211, 9307, 3660, 4032, 413, 1359, 15844, 413, 9122, 3555, 2655, 34105, 18871, 16254, 6055, 3794, 27884, 9154, 6225, 8592, 25720], "avg_logprob": -0.30885417991214326, "compression_ratio": 1.3671875, "no_speech_prob": 0.0, "words": [{"start": 3622.32, "end": 3622.68, "word": "اللي", "probability": 0.62548828125}, {"start": 3622.68, "end": 3622.84, "word": " هي", "probability": 0.71533203125}, {"start": 3622.84, "end": 3623.34, "word": " هتكون", "probability": 0.8738606770833334}, {"start": 3623.34, "end": 3623.52, "word": " في", "probability": 0.91162109375}, {"start": 3623.52, "end": 3623.96, "word": " المنطقة", "probability": 0.9678955078125}, {"start": 3623.96, "end": 3624.32, "word": " هذه", 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"probability": 0.84619140625}], "temperature": 1.0}, {"id": 144, "seek": 422383, "start": 4207.43, "end": 4223.83, "text": "بتساوي اللي هي باي في ايه في دي اص اربع minus دي small اص اربع على اتنين و تلاتين", "tokens": [3555, 2655, 3794, 995, 45865, 13672, 1829, 39896, 4724, 47302, 8978, 1975, 1829, 3224, 8978, 11778, 1829, 1975, 9381, 1975, 25513, 3615, 3175, 11778, 1829, 1359, 1975, 9381, 1975, 25513, 3615, 15844, 1975, 2655, 1863, 9957, 4032, 6055, 1211, 9307, 9957], "avg_logprob": -0.32012648099944707, "compression_ratio": 1.425531914893617, "no_speech_prob": 0.0, "words": [{"start": 4207.43, "end": 4208.25, "word": "بتساوي", "probability": 0.85380859375}, {"start": 4208.25, "end": 4208.65, "word": " اللي", "probability": 0.5543212890625}, {"start": 4208.65, "end": 4208.83, "word": " هي", "probability": 0.86572265625}, {"start": 4208.83, "end": 4209.33, "word": " باي", "probability": 0.439208984375}, {"start": 4209.33, "end": 4209.53, "word": " في", "probability": 0.8525390625}, 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"start": 4267.82, "end": 4286.52, "text": "برضه من الجدول هذا .. من الجدول هذا انا a على d انا هكون في المنطقة هذه", "tokens": [26890, 11242, 3224, 9154, 25724, 3215, 12610, 23758, 4386, 9154, 25724, 3215, 12610, 23758, 1975, 8315, 257, 15844, 274, 1975, 8315, 8032, 30544, 8978, 9673, 1863, 9566, 28671, 29538], "avg_logprob": -0.16575521330038706, "compression_ratio": 1.4022988505747127, "no_speech_prob": 0.0, "words": [{"start": 4267.82, "end": 4268.24, "word": "برضه", "probability": 0.8972981770833334}, {"start": 4268.24, "end": 4268.38, "word": " من", "probability": 0.98291015625}, {"start": 4268.38, "end": 4268.74, "word": " الجدول", "probability": 0.9119466145833334}, {"start": 4268.74, "end": 4269.14, "word": " هذا", "probability": 0.603515625}, {"start": 4269.14, "end": 4269.46, "word": " ..", "probability": 0.392578125}, {"start": 4269.46, "end": 4269.72, "word": " من", "probability": 0.96044921875}, {"start": 4269.72, "end": 4270.1, "word": " الجدول", "probability": 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interpolation عشان أحسب ال a هنا و أحسب ال kt ال a و ال kt يعني مانعته بالزمن أحسب kts", "tokens": [10721, 8315, 43242, 2423, 39896, 11778, 1829, 1359, 15844, 11778, 1829, 4238, 46811, 10943, 9154, 6225, 8592, 25720, 3714, 29245, 23328, 3660, 4724, 25957, 1211, 44902, 399, 6225, 8592, 7649, 5551, 5016, 35457, 2423, 257, 34105, 4032, 5551, 5016, 35457, 2423, 350, 83, 2423, 257, 4032, 2423, 350, 83, 37495, 22653, 3714, 7649, 34268, 3224, 20666, 11622, 27842, 5551, 5016, 35457, 350, 1373], "avg_logprob": -0.23962401878088713, "compression_ratio": 1.519736842105263, "no_speech_prob": 0.0, "words": [{"start": 4297.71, "end": 4297.99, "word": "أنا", "probability": 0.7110595703125}, {"start": 4297.99, "end": 4298.21, "word": " عند", "probability": 0.890625}, {"start": 4298.21, "end": 4298.39, "word": " ال", "probability": 0.7412109375}, {"start": 4298.39, "end": 4298.63, "word": " هي", "probability": 0.29296875}, {"start": 4298.63, "end": 4300.77, "word": " دي", "probability": 0.74853515625}, 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alternating nominal لكل تربيع زائد تلاتة في KFS torsion في Tau alternating nominal لكل تربيع كل هذا أص نص", "tokens": [6027, 39184, 36595, 40062, 41641, 5296, 28820, 6055, 2288, 21292, 3615, 30767, 16373, 3215, 6055, 1211, 9307, 3660, 8978, 591, 29318, 3930, 82, 313, 8978, 314, 1459, 40062, 41641, 5296, 28820, 6055, 2288, 21292, 3615, 28242, 23758, 5551, 9381, 8717, 9381], "avg_logprob": -0.31249999290420893, "compression_ratio": 1.3109243697478992, "no_speech_prob": 0.0, "words": [{"start": 4434.58, "end": 4435.04, "word": "الـ", "probability": 0.334228515625}, {"start": 4435.04, "end": 4435.42, "word": " Sigma", "probability": 0.4384765625}, {"start": 4435.42, "end": 4436.9, "word": " alternating", "probability": 0.8046875}, {"start": 4436.9, "end": 4438.1, "word": " nominal", "probability": 0.95556640625}, {"start": 4438.1, "end": 4440.34, "word": " لكل", "probability": 0.6705322265625}, {"start": 4440.34, "end": 4441.18, "word": " تربيع", "probability": 0.8631591796875}, {"start": 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تربية بالساوية واحد عند هذا ال term مش بيساوي سفر مانا بتحسر عندي N Sigma A Prime على SE", "tokens": [3615, 23942, 10269, 20666, 11622, 995, 25708, 426, 36595, 376, 9655, 15844, 318, 8709, 2423, 28820, 6055, 25513, 10632, 20666, 3794, 995, 2407, 10632, 36764, 24401, 43242, 23758, 2423, 1433, 37893, 4724, 1829, 3794, 995, 45865, 8608, 5172, 2288, 3714, 7649, 995, 39894, 5016, 3794, 2288, 18871, 16254, 426, 36595, 316, 9655, 15844, 10269], "avg_logprob": -0.3840909069234675, "compression_ratio": 1.4055944055944056, "no_speech_prob": 4.172325134277344e-07, "words": [{"start": 4802.52, "end": 4802.86, "word": "على", "probability": 0.7215576171875}, {"start": 4802.86, "end": 4803.68, "word": " SE", "probability": 0.5224609375}, {"start": 4803.68, "end": 4806.5, "word": " بالزايد", "probability": 0.59051513671875}, {"start": 4806.5, "end": 4809.1, "word": " N", "probability": 0.41357421875}, {"start": 4809.1, "end": 4810.84, "word": " Sigma", "probability": 0.62060546875}, {"start": 4810.84, 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وستين", "probability": 0.8896484375}, {"start": 5036.72, "end": 5037.56, "word": " على", "probability": 0.72216796875}, {"start": 5037.56, "end": 5038.1, "word": " اتنين", "probability": 0.968017578125}, {"start": 5038.1, "end": 5038.74, "word": " يعني", "probability": 0.873046875}, {"start": 5038.74, "end": 5039.34, "word": " تسعين", "probability": 0.9776611328125}, {"start": 5039.34, "end": 5040.0, "word": " نيوتن", "probability": 0.9622802734375}, {"start": 5040.0, "end": 5040.72, "word": " متر", "probability": 0.987060546875}], "temperature": 1.0}, {"id": 174, "seek": 506834, "start": 5041.32, "end": 5068.34, "text": "الـ T alternating سواء مية و ستين ناقص عشرين على اتنين سبعين نيوتن متر وال M mean سواء مية و خمسين نيوتن متر وال M alternating بالساوية سفر I follow the same procedure", "tokens": [6027, 39184, 314, 40062, 8608, 2407, 16606, 3714, 10632, 4032, 8608, 2655, 9957, 8717, 995, 4587, 9381, 6225, 46309, 9957, 15844, 1975, 2655, 1863, 9957, 8608, 3555, 3615, 9957, 8717, 1829, 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0.8763427734375}, {"start": 5046.86, "end": 5047.68, "word": " عشرين", "probability": 0.9441731770833334}, {"start": 5047.68, "end": 5048.42, "word": " على", "probability": 0.69287109375}, {"start": 5048.42, "end": 5048.94, "word": " اتنين", "probability": 0.95703125}, {"start": 5048.94, "end": 5050.24, "word": " سبعين", "probability": 0.962646484375}, {"start": 5050.24, "end": 5051.34, "word": " نيوتن", "probability": 0.845458984375}, {"start": 5051.34, "end": 5052.0, "word": " متر", "probability": 0.975341796875}, {"start": 5052.0, "end": 5053.42, "word": " وال", "probability": 0.4873046875}, {"start": 5053.42, "end": 5053.98, "word": " M", "probability": 0.5615234375}, {"start": 5053.98, "end": 5055.22, "word": " mean", "probability": 0.669921875}, {"start": 5055.22, "end": 5056.18, "word": " سواء", "probability": 0.9085286458333334}, {"start": 5056.18, "end": 5056.42, "word": " مية", "probability": 0.968505859375}, {"start": 5056.42, "end": 5056.52, "word": " و", "probability": 0.99658203125}, {"start": 5056.52, "end": 5057.04, "word": " خمسين", "probability": 0.9678955078125}, {"start": 5057.04, "end": 5058.04, "word": " نيوتن", "probability": 0.9613037109375}, {"start": 5058.04, "end": 5058.46, "word": " متر", "probability": 0.99169921875}, {"start": 5058.46, "end": 5059.16, "word": " وال", "probability": 0.88818359375}, {"start": 5059.16, "end": 5059.62, "word": " M", "probability": 0.884765625}, {"start": 5059.62, "end": 5061.66, "word": " alternating", "probability": 0.884765625}, {"start": 5061.66, "end": 5062.66, "word": " بالساوية", "probability": 0.8462890625}, {"start": 5062.66, "end": 5064.48, "word": " سفر", "probability": 0.8160807291666666}, {"start": 5064.48, "end": 5067.14, "word": " I", "probability": 0.61328125}, {"start": 5067.14, "end": 5067.54, "word": " follow", "probability": 0.76416015625}, {"start": 5067.54, "end": 5067.72, "word": " the", "probability": 0.85791015625}, {"start": 5067.72, "end": 5067.9, "word": " same", "probability": 0.89404296875}, {"start": 5067.9, "end": 5068.34, "word": " procedure", "probability": 0.95166015625}], "temperature": 1.0}, {"id": 175, "seek": 509704, "start": 5069.92, "end": 5097.04, "text": "هحسب sigma prime alternating نرجع للمعادلات اللي هي KF لل bending طبعا انا في الحالة هذه هتكون هذه صفر صفر هتكون تساوي تلاتة", "tokens": [3224, 5016, 35457, 12771, 5835, 40062, 8717, 47341, 3615, 5296, 19528, 3615, 18513, 1211, 9307, 13672, 1829, 39896, 591, 37, 24976, 22487, 23032, 3555, 3615, 995, 1975, 8315, 8978, 21542, 6027, 3660, 29538, 8032, 2655, 30544, 29538, 20328, 5172, 2288, 20328, 5172, 2288, 8032, 2655, 30544, 6055, 3794, 995, 45865, 6055, 1211, 9307, 3660], "avg_logprob": -0.2420454529198733, "compression_ratio": 1.3611111111111112, "no_speech_prob": 0.0, "words": [{"start": 5069.92, "end": 5070.6, "word": "هحسب", "probability": 0.73876953125}, {"start": 5070.6, "end": 5071.68, "word": " sigma", "probability": 0.40185546875}, {"start": 5071.68, "end": 5072.38, "word": " prime", "probability": 0.783203125}, {"start": 5072.38, "end": 5074.9, "word": " alternating", "probability": 0.83154296875}, {"start": 5074.9, "end": 5076.84, "word": " نرجع", "probability": 0.7822265625}, {"start": 5076.84, "end": 5077.78, "word": " للمعادلات", "probability": 0.857177734375}, {"start": 5077.78, "end": 5082.34, "word": " اللي", "probability": 0.471435546875}, {"start": 5082.34, "end": 5082.52, "word": " هي", "probability": 0.83740234375}, {"start": 5082.52, "end": 5083.22, "word": " KF", "probability": 0.6513671875}, {"start": 5083.22, "end": 5084.58, "word": " لل", "probability": 0.767578125}, {"start": 5084.58, "end": 5085.08, "word": " bending", "probability": 0.630859375}, {"start": 5085.08, "end": 5088.84, "word": " طبعا", "probability": 0.9852294921875}, {"start": 5088.84, "end": 5089.16, "word": " انا", "probability": 0.755126953125}, {"start": 5089.16, "end": 5089.28, "word": " في", "probability": 0.92529296875}, {"start": 5089.28, "end": 5089.64, "word": " الحالة", "probability": 0.9484049479166666}, {"start": 5089.64, "end": 5089.86, "word": " هذه", "probability": 0.71875}, {"start": 5089.86, "end": 5090.22, "word": " هتكون", "probability": 0.84130859375}, {"start": 5090.22, "end": 5090.58, "word": " هذه", "probability": 0.77490234375}, {"start": 5090.58, "end": 5092.48, "word": " صفر", "probability": 0.88720703125}, {"start": 5092.48, "end": 5093.06, "word": " صفر", "probability": 0.8223470052083334}, {"start": 5093.06, "end": 5093.48, "word": " هتكون", "probability": 0.9402669270833334}, {"start": 5093.48, "end": 5094.0, "word": " تساوي", "probability": 0.776123046875}, {"start": 5094.0, "end": 5097.04, "word": " تلاتة", "probability": 0.947265625}], "temperature": 1.0}, {"id": 176, "seek": 512702, "start": 5100.36, "end": 5127.02, "text": "كفاس في tau alternating nominal الكل تربيع كله تحت الجدر و ال sigma prime main هتكون ساوى كف sigma main", "tokens": [4117, 5172, 32277, 8978, 17842, 40062, 41641, 2423, 28820, 6055, 25513, 40228, 28242, 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0.99609375}, {"start": 5114.1, "end": 5114.52, "word": " الجدر", "probability": 0.97314453125}, {"start": 5114.52, "end": 5117.3, "word": " و", "probability": 0.54052734375}, {"start": 5117.3, "end": 5117.46, "word": " ال", "probability": 0.5908203125}, {"start": 5117.46, "end": 5117.74, "word": " sigma", "probability": 0.77001953125}, {"start": 5117.74, "end": 5119.92, "word": " prime", "probability": 0.5205078125}, {"start": 5119.92, "end": 5120.48, "word": " main", "probability": 0.5927734375}, {"start": 5120.48, "end": 5121.52, "word": " هتكون", "probability": 0.8878580729166666}, {"start": 5121.52, "end": 5122.62, "word": " ساوى", "probability": 0.758056640625}, {"start": 5122.62, "end": 5123.38, "word": " كف", "probability": 0.850830078125}, {"start": 5123.38, "end": 5126.62, "word": " sigma", "probability": 0.5712890625}, {"start": 5126.62, "end": 5127.02, "word": " main", "probability": 0.462890625}], "temperature": 1.0}, {"id": 177, "seek": 515306, "start": 5129.22, "end": 5153.06, "text": "نومينال كل تربيع زائد تلاتة في KFS تاومين نومينال كل تربيع الكل اص نص يعني انا عندي هكون عندي sigma alternating born mice sigma prime born mice اللي انا على فرق كتير عند هاي gear bar", "tokens": [1863, 20498, 9957, 6027, 28242, 6055, 2288, 21292, 3615, 30767, 16373, 3215, 6055, 1211, 9307, 3660, 8978, 591, 29318, 6055, 995, 20498, 9957, 8717, 20498, 9957, 6027, 28242, 6055, 2288, 21292, 3615, 2423, 28820, 1975, 9381, 8717, 9381, 37495, 22653, 1975, 8315, 18871, 16254, 8032, 30544, 18871, 16254, 12771, 40062, 4232, 22257, 12771, 5835, 4232, 22257, 13672, 1829, 1975, 8315, 15844, 6156, 2288, 4587, 9122, 2655, 13546, 43242, 8032, 47302, 7394, 2159], "avg_logprob": -0.42829622307868853, "compression_ratio": 1.6198830409356726, "no_speech_prob": 0.0, "words": [{"start": 5129.22, "end": 5130.14, "word": "نومينال", "probability": 0.66424560546875}, {"start": 5130.14, "end": 5131.06, "word": " كل", "probability": 0.47119140625}, {"start": 5131.06, "end": 5131.76, "word": " تربيع", "probability": 0.8277587890625}, {"start": 5131.76, "end": 5133.1, "word": " زائد", "probability": 0.85546875}, {"start": 5133.1, "end": 5134.26, "word": " تلاتة", "probability": 0.9447021484375}, {"start": 5134.26, "end": 5134.86, "word": " في", "probability": 0.55224609375}, {"start": 5134.86, "end": 5136.04, "word": " KFS", "probability": 0.8193359375}, {"start": 5136.04, "end": 5137.7, "word": " تاومين", "probability": 0.68865966796875}, {"start": 5137.7, "end": 5139.12, "word": " نومينال", "probability": 0.7960205078125}, {"start": 5139.12, "end": 5139.48, "word": " كل", "probability": 0.73095703125}, {"start": 5139.48, "end": 5140.08, "word": " تربيع", "probability": 0.9305419921875}, {"start": 5140.08, "end": 5140.98, "word": " الكل", "probability": 0.642578125}, {"start": 5140.98, "end": 5141.32, "word": " اص", "probability": 0.59820556640625}, {"start": 5141.32, "end": 5141.68, "word": " نص", "probability": 0.78369140625}, {"start": 5141.68, "end": 5142.2, "word": " يعني", "probability": 0.932373046875}, {"start": 5142.2, "end": 5142.32, "word": " انا", "probability": 0.827880859375}, {"start": 5142.32, "end": 5142.64, "word": " عندي", "probability": 0.79150390625}, {"start": 5142.64, "end": 5143.54, "word": " هكون", "probability": 0.5745849609375}, {"start": 5143.54, "end": 5143.76, "word": " عندي", "probability": 0.79736328125}, {"start": 5143.76, "end": 5144.2, "word": " sigma", "probability": 0.323974609375}, {"start": 5144.2, "end": 5145.98, "word": " alternating", "probability": 0.9228515625}, {"start": 5145.98, "end": 5146.28, "word": " born", "probability": 0.1954345703125}, {"start": 5146.28, "end": 5146.52, "word": " mice", "probability": 0.84814453125}, {"start": 5146.52, "end": 5146.78, "word": " sigma", "probability": 0.52294921875}, {"start": 5146.78, "end": 5147.14, "word": " prime", "probability": 0.796875}, {"start": 5147.14, "end": 5147.6, "word": " born", "probability": 0.7685546875}, {"start": 5147.6, "end": 5147.98, "word": " mice", "probability": 0.71484375}, {"start": 5147.98, "end": 5148.8, "word": " اللي", "probability": 0.56304931640625}, {"start": 5148.8, "end": 5149.0, "word": " انا", "probability": 0.775146484375}, {"start": 5149.0, "end": 5149.3, "word": " على", "probability": 0.67724609375}, {"start": 5149.3, "end": 5150.92, "word": " فرق", "probability": 0.5453287760416666}, {"start": 5150.92, "end": 5151.24, "word": " كتير", "probability": 0.7784830729166666}, {"start": 5151.24, "end": 5151.46, "word": " عند", "probability": 0.39013671875}, {"start": 5151.46, "end": 5152.38, "word": " هاي", "probability": 0.6458740234375}, {"start": 5152.38, "end": 5152.84, "word": " gear", "probability": 0.1588134765625}, {"start": 5152.84, "end": 5153.06, "word": " bar", "probability": 0.93798828125}], "temperature": 1.0}, {"id": 178, "seek": 518120, "start": 5153.96, "end": 5181.2, "text": "هذه S U T وهذه S E وهذه ال load ال load line هحسب S M و S alternating ومنها بحسب ال N F بالساوية اللي هي S M", "tokens": 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components،", "probability": 0.847412109375}, {"start": 5276.78, "end": 5276.9, "word": " دي", "probability": 0.8125}, {"start": 5276.9, "end": 5277.04, "word": " كل", "probability": 0.98779296875}, {"start": 5277.04, "end": 5277.26, "word": " عالم", "probability": 0.6177978515625}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 5278.0814375, "duration_after_vad": 4434.660000000009}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/EruFwa8nhZA_raw.srt b/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/EruFwa8nhZA_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..ed590da3815e75f6e1a0a3677945e83f0b9ea38d
--- /dev/null
+++ b/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/EruFwa8nhZA_raw.srt
@@ -0,0 +1,2948 @@
+1
+00:00:04,880 --> 00:00:07,420
+بسم الله الرحمن الرحيم السلام عليكم و رحمة الله
+
+2
+00:00:07,420 --> 00:00:12,620
+اليوم هنكمل اللي هو fatigue failure due to dynamic
+
+3
+00:00:12,620 --> 00:00:16,240
+loading في المحاضرات السابقة حكينا عن fatigue
+
+4
+00:00:16,240 --> 00:00:22,280
+criteria for ductile materials اتعرفنا على ال S
+
+5
+00:00:22,280 --> 00:00:28,080
+-endogram ال S-endogram فرضنا او حددنا مناطق
+
+6
+00:00:28,080 --> 00:00:32,930
+finite life و infinite lifeكان في علاقة بين ال
+
+7
+00:00:32,930 --> 00:00:36,530
+endurance limit وال tensile strength بشكل عام ال
+
+8
+00:00:36,530 --> 00:00:41,870
+SE prime بصفر نص ال SUT في
+
+9
+00:00:41,870 --> 00:00:45,270
+حالة ال finite life جيبنا معدلات في حالة كانت
+
+10
+00:00:45,270 --> 00:00:50,170
+العمر ال ال part من واحد لألف cycle جيبنا equation
+
+11
+00:00:50,640 --> 00:00:53,680
+و جيبنا equation في حالة كانت ال life من الف
+
+12
+00:00:53,680 --> 00:00:59,500
+لمليون cycle و بعدين بدنا ندرس في ال infinite ..
+
+13
+00:00:59,500 --> 00:01:03,060
+في ال design .. fatigue design for infinite life
+
+14
+00:01:03,060 --> 00:01:07,580
+في الحالة دي كان يلزمنا نعمل تعديلات على ال .. او
+
+15
+00:01:07,580 --> 00:01:11,940
+تعديلات على ال endurance limit لان ال endurance
+
+16
+00:01:11,940 --> 00:01:15,560
+limit لما تم قياسة .. اقتم قياسة لعينة معيارية
+
+17
+00:01:15,560 --> 00:01:19,520
+بمواصفات شكل او مقطع هندس معين و في surface finish
+
+18
+00:01:19,520 --> 00:01:23,850
+معينزاد ال loading كان completely reversed pending
+
+19
+00:01:23,850 --> 00:01:27,310
+لكن على الأرض الواقع بيكونش نفس ال surface finish
+
+20
+00:01:27,310 --> 00:01:30,570
+بيكونش نفس ال .. ال .. ال .. الكتر ال loading
+
+21
+00:01:30,570 --> 00:01:36,030
+مختلف القطعة ممكن تكون مدورة ممكن تكون مدورة مش
+
+22
+00:01:36,030 --> 00:01:40,450
+مدورة درجة الحرارة reliability كل هذه العوامل لازم
+
+23
+00:01:40,450 --> 00:01:43,150
+نعملها modification factor عشان هيك حكينا SE
+
+24
+00:01:43,150 --> 00:01:48,730
+بالساوية K A K B K C K D K A K F في SE prime
+
+25
+00:01:53,010 --> 00:01:56,690
+بعدين أخدنا الحالة اللى بتكون عندى اللى هو ال
+
+26
+00:01:56,690 --> 00:02:03,010
+general fluctuating case حسبنا ال alternating
+
+27
+00:02:03,010 --> 00:02:07,310
+stress و ال mean stress و بعدين we apply design
+
+28
+00:02:07,310 --> 00:02:10,290
+theory اللى هي modified Godman theory و الgerber
+
+29
+00:02:10,290 --> 00:02:13,190
+theory و ال asthma elliptic و Stoderberg for
+
+30
+00:02:13,190 --> 00:02:17,770
+fatigue design for yielding we apply اللى هو ال
+
+31
+00:02:17,770 --> 00:02:24,140
+Langer lineبعدين أخدنا حالة أكثر عمومية أنه ال
+
+32
+00:02:24,140 --> 00:02:26,840
+loading ممكن يكون multiple loading conditions ممكن
+
+33
+00:02:26,840 --> 00:02:30,020
+يكون عندك axial loading مع torsion مع .. مع
+
+34
+00:02:30,020 --> 00:02:35,960
+bending في الحالة هذه بنحسب .. حسبنا alternating
+
+35
+00:02:35,960 --> 00:02:40,940
+volumizes stress و mid range volumizes stress
+
+36
+00:02:40,940 --> 00:02:43,720
+بعدين أخدنا ال .. ال .. ال هو sigma a prime و
+
+37
+00:02:43,720 --> 00:02:46,560
+sigma m prime و ي apply ال design theories اللي
+
+38
+00:02:46,560 --> 00:02:49,240
+ذكرناها السابقين اللي هم ال good .. المدفعة
+
+39
+00:02:49,240 --> 00:02:52,430
+goodmanوالجيربر و الازميل الليبتيك والسودربيرج
+
+40
+00:02:52,430 --> 00:02:57,670
+حللنا مجموعة من الأمثلة for ductile materials
+
+41
+00:02:57,670 --> 00:03:01,050
+اليوم هنكمل في الفتيه criteria for brittle
+
+42
+00:03:01,050 --> 00:03:07,590
+materials في حالة ال brittle materials احنا عشان
+
+43
+00:03:07,590 --> 00:03:15,090
+نعمل design criteria كان يكون لنا curve هنا عندى
+
+44
+00:03:15,090 --> 00:03:21,580
+ال sigma Mع ال x axis و ال sigma alternating على
+
+45
+00:03:21,580 --> 00:03:30,700
+ال y axis في حالة brittle materials ال design
+
+46
+00:03:30,700 --> 00:03:36,060
+theory it will depend on
+
+47
+00:03:36,060 --> 00:03:36,640
+two curves
+
+48
+00:03:49,330 --> 00:03:51,690
+إذا كان الـ sigma alternating و ال sigma mean
+
+49
+00:03:51,690 --> 00:03:56,350
+موجبين هنكون في ال first quadrant إذا كانت ال
+
+50
+00:03:56,350 --> 00:03:59,150
+sigma mean negative و ال sigma alternating ال
+
+51
+00:03:59,150 --> 00:04:02,310
+sigma alternating دايما موجبة ال sigma mean ممكن
+
+52
+00:04:02,310 --> 00:04:05,790
+تكون موجبة أو سلبة إذا كانت ال sigma mean سلبة
+
+53
+00:04:05,790 --> 00:04:08,970
+يعني هنكون في الرابع التاني في حال تكون في الرابع
+
+54
+00:04:08,970 --> 00:04:16,690
+الأول في design criteria هنا عندي sut وهنا عندي se
+
+55
+00:04:19,180 --> 00:04:24,100
+في حال كنا في ال first quadrant ال fatigue في ال
+
+56
+00:04:24,100 --> 00:04:27,900
+criteria follows concave upward concave upward
+
+57
+00:04:27,900 --> 00:04:33,440
+smith dallon equation اللي هي given by this
+
+58
+00:04:33,440 --> 00:04:38,120
+equation S المعادلة هذه لأن هذا concave up curve
+
+59
+00:04:38,120 --> 00:04:44,910
+جاء بين ال S U T و ال S E ال S A في الحالة هذهS A
+
+60
+00:04:44,910 --> 00:04:57,470
+على S E بالساوية واحد minus S M على S U T على واحد
+
+61
+00:04:57,470 --> 00:05:03,450
+زائد S M على S U T طبعا هذا ال loading line بتاعنا
+
+62
+00:05:03,450 --> 00:05:15,600
+هذا ال load line ان هي اللي هتكون ال sigma Mو الـ
+
+63
+00:05:15,600 --> 00:05:26,160
+Sigma alternating هذه SM وهذه S alternating طبعا
+
+64
+00:05:26,160 --> 00:05:29,160
+هذه المعادلة في حالة احنا كنا واقعين على ال filler
+
+65
+00:05:29,160 --> 00:05:35,720
+line لكن لو حطينا factor of safety حصير عنده هذه
+
+66
+00:05:35,720 --> 00:05:44,900
+حصير N Sigma Aعلى SE بيصيح واحد minus N Sigma M
+
+67
+00:05:44,900 --> 00:05:55,180
+على SUT على واحد زاد N Sigma M على SUT هذا في ال
+
+68
+00:05:55,180 --> 00:06:00,300
+first quadrant في ال second quadrant او خلينا نجد
+
+69
+00:06:00,300 --> 00:06:04,960
+نقطة التقاطع هذه لأن نقطة التقاطع اللي هي خط ال
+
+70
+00:06:04,960 --> 00:06:09,040
+loading lineمع ال failure line اللي هي تُعطى
+
+71
+00:06:09,040 --> 00:06:19,320
+بيحدثية SM و SA و ال slope لل load line R لسه و SA
+
+72
+00:06:19,320 --> 00:06:26,780
+على SM بتكون
+
+73
+00:06:26,780 --> 00:06:34,430
+الالـ S A اللي هي هذه تعتبر علاقة S A بسوا R S U T
+
+74
+00:06:34,430 --> 00:06:38,390
+زاد S E على 2 في minus 1 زاد الجزر التربيعي ل 1
+
+75
+00:06:38,390 --> 00:06:43,850
+زاد 4R S U T S E على R S U T زاد S E لكل تربيع
+
+76
+00:06:43,850 --> 00:06:48,670
+والـ R راح ينحكينا بسوا S A على S M هذا طبعا في ال
+
+77
+00:06:48,670 --> 00:06:52,570
+first quadrant في ال second quadrant ال fair
+
+78
+00:06:52,570 --> 00:06:56,890
+criteria is described by a linear by a line هذا ال
+
+79
+00:06:56,890 --> 00:07:07,480
+lineline ال slope بتاع الخط هذا slope of
+
+80
+00:07:07,480 --> 00:07:14,700
+the failure line بيساوي
+
+81
+00:07:14,700 --> 00:07:19,400
+ال slope of
+
+82
+00:07:19,400 --> 00:07:29,150
+failure line of failure curve and firstquadrant
+
+83
+00:07:29,150 --> 00:07:33,310
+عند
+
+84
+00:07:33,310 --> 00:07:42,810
+النقطة اللي هي zero و SE يعني عند النقطة هذه لأن
+
+85
+00:07:42,810 --> 00:07:50,130
+based on this principle هتكون عندى معادلة اللي هي
+
+86
+00:07:50,130 --> 00:07:51,330
+second line
+
+87
+00:07:59,540 --> 00:08:11,820
+اللي هي SA هتكون تساوي SE زائد SE minus
+
+88
+00:08:11,820 --> 00:08:20,740
+SE على S UT minus واحد طبعا ال load line هذا ال
+
+89
+00:08:20,740 --> 00:08:24,640
+load line تاني هذا ال load line
+
+90
+00:08:29,270 --> 00:08:35,770
+هذا النقطة هتكون SM وهذا SA
+
+91
+00:08:54,500 --> 00:08:57,360
+طب في ال first quadrant ال sigma alternating و
+
+92
+00:08:57,360 --> 00:08:59,720
+sigma mean both positive في ال second quadrant
+
+93
+00:08:59,720 --> 00:09:04,300
+sigma a is positive و sigma m is negative لأن
+
+94
+00:09:04,300 --> 00:09:10,560
+table A24 في الكتاب بيعطينا الخواص الميكانيكية لل
+
+95
+00:09:10,560 --> 00:09:14,460
+grey cast iron من ضمن الخواص اللي هي ال endurance
+
+96
+00:09:14,460 --> 00:09:21,600
+limit إذا بنروح على table A24 اللي
+
+97
+00:09:21,600 --> 00:09:22,100
+هو هذا
+
+98
+00:09:28,500 --> 00:09:32,140
+معطين different grades of grade cast iron اللي هو
+
+99
+00:09:32,140 --> 00:09:35,440
+cast iron عشرين، خمسة عشرين، تلاتين، خمس تلاتين،
+
+100
+00:09:35,440 --> 00:09:39,860
+اربعين، خمسين، ستين ومعطين ال tensile strength و
+
+101
+00:09:39,860 --> 00:09:43,320
+ال compressive strength ال SUC و ال shear modulus
+
+102
+00:09:43,320 --> 00:09:51,260
+ال S .. S .. rupture SSU و ال modulus of
+
+103
+00:09:51,260 --> 00:09:55,380
+elasticity in tension و in torsion و ال endurance
+
+104
+00:09:55,380 --> 00:09:56,100
+limit
+
+105
+00:10:02,600 --> 00:10:09,880
+زاد خواص تاني طبعا
+
+106
+00:10:09,880 --> 00:10:19,420
+ال endurance limit اللي مُعطاه في ال table A24 ال
+
+107
+00:10:19,420 --> 00:10:23,100
+endurance limit اللي مُعطاه في ال table 24 ال
+
+108
+00:10:23,100 --> 00:10:28,360
+already includes ال K A و ال K B ال endurance
+
+109
+00:10:28,360 --> 00:10:33,780
+limit given in table 24 already includeالـ K A و
+
+110
+00:10:33,780 --> 00:10:37,660
+ال K B ال K A اللي هو ال modification factor for
+
+111
+00:10:37,660 --> 00:10:41,060
+the surface finish و ال K B ال modification factor
+
+112
+00:10:41,060 --> 00:10:42,140
+for size
+
+113
+00:10:45,110 --> 00:10:49,610
+والـ average value KC for axial and torsional
+
+114
+00:10:49,610 --> 00:10:54,370
+loading is 0.9 طبعا في حالة bending بتكون ال KC
+
+115
+00:10:54,370 --> 00:10:59,750
+بيستوي واحد يعني احنا في حالة ال cast iron هنستخدم
+
+116
+00:10:59,750 --> 00:11:05,110
+table A24 من table A24 بنطلع ال S S .. بنطلع اللي
+
+117
+00:11:05,110 --> 00:11:12,980
+هو ال S UT و ال S UCوبنطلع ال SE prime SE prime
+
+118
+00:11:12,980 --> 00:11:16,340
+already متضمن فيها اللي هو ال surface finish
+
+119
+00:11:16,340 --> 00:11:20,680
+factor و ال size factor اللي هو ان في حالة bending
+
+120
+00:11:20,680 --> 00:11:24,780
+load بتكون ال KC بساوة واحد في حالة axle او
+
+121
+00:11:24,780 --> 00:11:32,200
+torsion load ال KC هنحطها تسعة من عشرة نشوف
+
+122
+00:11:32,200 --> 00:11:32,980
+و نحل المثال
+
+123
+00:11:50,490 --> 00:11:56,130
+a grade thirty gray cast iron يعني عندي حديد سكب
+
+124
+00:11:56,130 --> 00:12:06,930
+اللي هو cast iron grade تلاتين
+
+125
+00:12:09,610 --> 00:12:13,710
+is subjected to a load applied to a one point by
+
+126
+00:12:13,710 --> 00:12:17,450
+three seven inch cross section link with one
+
+127
+00:12:17,450 --> 00:12:20,330
+fourth inch diameter hole drilled in the center
+
+128
+00:12:20,330 --> 00:12:30,150
+بيبين دي شكل هين عندي قطعة معدنيةمستطيلة المقطع
+
+129
+00:12:30,150 --> 00:12:32,950
+بتاعها مستطيل السماكة القطعة تلاتة ع تمانية انش
+
+130
+00:12:32,950 --> 00:12:40,470
+وعرض القطعة واحد انش وفي force tension force F وفي
+
+131
+00:12:40,470 --> 00:12:52,410
+هنا في النص ثقب كتر ربع انش كتر ثقب ربع انش The
+
+132
+00:12:52,410 --> 00:12:56,870
+surfaces are machined الأسطح machined
+
+133
+00:13:02,640 --> 00:13:05,980
+in the neighborhood of the hole على مقرب من الثقب
+
+134
+00:13:05,980 --> 00:13:10,580
+what is the factor of safety guarding against
+
+135
+00:13:10,580 --> 00:13:13,660
+fatigue against failure under the following
+
+136
+00:13:13,660 --> 00:13:19,640
+conditions بده ال factor of safety against failure
+
+137
+00:13:19,640 --> 00:13:22,200
+في الحالات التالية الحالة الأولى
+
+138
+00:13:25,700 --> 00:13:30,100
+الـ load ال F بساوة
+
+139
+00:13:30,100 --> 00:13:38,700
+ألف pound steady steady
+
+140
+00:13:38,700 --> 00:13:42,820
+يعني ثابتة يعني في الحال هذا هتكون عندى ال F
+
+141
+00:13:42,820 --> 00:13:51,700
+alternating بساوة سفر وال F mean بساوة ألف pound
+
+142
+00:13:51,700 --> 00:13:54,120
+بده ال factor of safety
+
+143
+00:14:04,810 --> 00:14:12,670
+يعني .. يعني هذه النقطة هتكون طبعا
+
+144
+00:14:12,670 --> 00:14:16,230
+عشان احسب ال stress .. اول شي طبعا خلينا اول شي
+
+145
+00:14:16,230 --> 00:14:21,730
+نطلع .. نطلع الخواص الميكانيكي اول شي هو cast iron
+
+146
+00:14:21,730 --> 00:14:26,310
+اول شي هو cast iron بمعناته هنروح على ال table A24
+
+147
+00:14:26,310 --> 00:14:29,450
+هو
+
+148
+00:14:29,450 --> 00:14:30,390
+grade 30
+
+149
+00:14:33,870 --> 00:14:38,430
+جريد تلاتين معناته
+
+150
+00:14:38,430 --> 00:14:48,830
+ال SUT نروح على التابل A24 ستكون ال SUT بالساوية
+
+151
+00:14:48,830 --> 00:14:53,050
+واحد تلاتين كيلو pound per square inch واحد تلاتين
+
+152
+00:14:53,050 --> 00:15:01,550
+كيلو pound per square inch وال SUC مية وتسعة
+
+153
+00:15:05,160 --> 00:15:17,620
+بس هو مية وتسعة كيلو pound per square inch و
+
+154
+00:15:17,620 --> 00:15:23,020
+ال endurance limit عندي ال SE prime اربعتاش و ال
+
+155
+00:15:23,020 --> 00:15:28,940
+SE prime اربعتاشر
+
+156
+00:15:28,940 --> 00:15:31,780
+كيلو pound per square inch
+
+157
+00:15:39,450 --> 00:15:45,430
+طيب نرجع لمسألة تاتنا عرفنا الخواص الميكانيكية
+
+158
+00:15:45,430 --> 00:15:49,990
+الآن
+
+159
+00:16:07,700 --> 00:16:10,860
+الان ال cross section ال area .. ال area بتاعة ال
+
+160
+00:16:10,860 --> 00:16:17,900
+cross section المقطع هنا هيكون لو
+
+161
+00:16:17,900 --> 00:16:22,820
+اتاخد مقطع عند الثقب
+
+162
+00:16:38,760 --> 00:16:45,680
+هذه ثلاثة على تمانية انش
+
+163
+00:16:45,680 --> 00:16:55,020
+وهذه واحد انش كلها وهذه
+
+164
+00:16:55,020 --> 00:17:05,480
+ربع انش معناته
+
+165
+00:17:05,480 --> 00:17:06,160
+هذه ستكون
+
+166
+00:17:24,220 --> 00:17:31,460
+هتكون واحد ناقص ربع تلت اربع على اتنين بون تلاتة
+
+167
+00:17:31,460 --> 00:17:40,340
+سبعة خمسة انش بون تلاتة سبعة خمسة انش معناته مساحة
+
+168
+00:17:40,340 --> 00:17:43,320
+ال net cross sectional area هتكون مساحة المستطيل
+
+169
+00:17:43,320 --> 00:17:51,800
+هذا زاد المستطيل هذا ال area بتاعة المقطع هتساوي
+
+170
+00:17:53,210 --> 00:17:58,230
+اللي هو تلاتة على تمانية في
+
+171
+00:17:58,230 --> 00:18:03,370
+أو
+
+172
+00:18:03,370 --> 00:18:06,930
+المستطيل هذا كله ناقص المستطيل الصغير اللي هو
+
+173
+00:18:06,930 --> 00:18:16,390
+تلاتة على تمانية في واحد ناقص
+
+174
+00:18:16,390 --> 00:18:17,590
+ربع
+
+175
+00:18:39,620 --> 00:18:45,300
+وبتطلع بونت اتنين تمانية واحد
+
+176
+00:18:45,300 --> 00:18:54,400
+اتنين خمسة انش مربع معناته
+
+177
+00:18:54,400 --> 00:19:00,620
+ال mean stress ال sigma alternating هتكون صحيح صفر
+
+178
+00:19:00,620 --> 00:19:06,500
+و ال sigma mean اللي هو ال nominal هتكون صحيح FM
+
+179
+00:19:09,230 --> 00:19:19,290
+FM على ال .. على ال .. على ال area FM اللي هى الف
+
+180
+00:19:19,290 --> 00:19:26,390
+ع ال area اللي هى point اتنين تمانية واحد اتنين
+
+181
+00:19:26,390 --> 00:19:29,950
+خمسة طبعا لو دي حوالي كيلو pound per square inch
+
+182
+00:19:29,950 --> 00:19:30,690
+هتكون
+
+183
+00:19:33,940 --> 00:19:43,560
+الف تقسيم point اتنين تمانية واحد اتنين خمسة تطلع
+
+184
+00:19:43,560 --> 00:19:49,260
+تلاتة point خمسة
+
+185
+00:19:49,260 --> 00:19:55,500
+خمسة ستة kilo pound per square inch
+
+186
+00:20:17,990 --> 00:20:24,930
+طيب بلزان نحسب ال KT لأن فعل دي هكون stress
+
+187
+00:20:24,930 --> 00:20:29,310
+concentration عشان
+
+188
+00:20:29,310 --> 00:20:33,730
+نحسب ال stress concentration
+
+189
+00:20:38,290 --> 00:20:42,490
+بلزمنا نحسب الـ KT نرجع لجداول اللي هو ال table
+
+190
+00:20:42,490 --> 00:20:43,150
+A15
+
+191
+00:21:18,180 --> 00:21:27,580
+لو هيكون a خمستاش واحد ليها دي
+
+192
+00:21:27,580 --> 00:21:33,740
+بلزمنا
+
+193
+00:21:33,740 --> 00:21:41,860
+d على w دي هيكون ان دي a خمستاش واحد بدي احسب d
+
+194
+00:21:41,860 --> 00:21:49,250
+على w دي اللي هي ربع على ال wاللي هي واحد انش
+
+195
+00:21:49,250 --> 00:21:56,430
+بيساوي point اتنين خمسة الان point اتنين خمسة احنا
+
+196
+00:21:56,430 --> 00:22:10,350
+هنكون هنا تقريبا
+
+197
+00:22:10,350 --> 00:22:15,350
+تطلع الكاتي اتنين
+
+198
+00:22:15,350 --> 00:22:29,930
+pointاربعة خمسة ال
+
+199
+00:22:29,930 --> 00:22:32,590
+keto طلعت nine point اربعة خمسة
+
+200
+00:23:08,170 --> 00:23:11,470
+طيب معناته استخدمنا ال table A 15 واحد عشان اطلع
+
+201
+00:23:11,470 --> 00:23:13,010
+ال stress concentration factor
+
+202
+00:23:47,200 --> 00:23:57,340
+في الحالة هذه النقطة على ال curve هي sigma mean و
+
+203
+00:23:57,340 --> 00:24:01,120
+sigma alternating النقطة هذه عبارة عن sigma
+
+204
+00:24:01,120 --> 00:24:04,700
+alternating صفر و sigma mean بساوية تلاتة point
+
+205
+00:24:04,700 --> 00:24:06,340
+خمسة خمسة ستة
+
+206
+00:24:31,600 --> 00:24:40,740
+طيب ال .. ال .. ال cast iron ال cast iron is
+
+207
+00:24:40,740 --> 00:24:43,240
+not sensitive
+
+208
+00:24:45,830 --> 00:25:06,270
+to notches في حالة in case of static loading يعني
+
+209
+00:25:06,270 --> 00:25:13,070
+ممكن احكي الان في الحالة هذهبالسواء SUT على Sigma
+
+210
+00:25:13,070 --> 00:25:20,630
+او الـ SUT اللي هي طلعناها
+
+211
+00:25:20,630 --> 00:25:25,350
+واحد و تلاتين على
+
+212
+00:25:25,350 --> 00:25:30,070
+واحد
+
+213
+00:25:30,070 --> 00:25:35,750
+و تلاتين على تلاتة point خمسة خمسة ستة
+
+214
+00:25:38,980 --> 00:25:46,120
+بس انا مع ذلك انا بفضل .. بفضل .. بفضل
+
+215
+00:25:46,120 --> 00:25:51,580
+اجي احكي انه ال sigma M هتكون في سواء KT في sigma
+
+216
+00:25:51,580 --> 00:25:58,800
+MA اللي هي هتكون تلاتة point اتنين point اربع خمسة
+
+217
+00:25:58,800 --> 00:26:02,640
+في تلاتة point خمسة خمسة ستة تطلع
+
+218
+00:26:26,100 --> 00:26:32,660
+تمانية bond السابعة واحد
+
+219
+00:26:32,660 --> 00:26:37,700
+اتنين اتنين المعنى
+
+220
+00:26:37,700 --> 00:26:43,240
+اللي بحكي ان ال N حساوي S U T على S M اللي هي
+
+221
+00:26:43,240 --> 00:26:46,920
+هتكون واحد تلاتين على تمانية bond السابعة واحد
+
+222
+00:26:46,920 --> 00:26:48,260
+اتنين اتنين
+
+223
+00:26:55,910 --> 00:27:06,490
+هتكون عندى تلاتة
+
+224
+00:27:06,490 --> 00:27:11,730
+point هذا
+
+225
+00:27:11,730 --> 00:27:17,990
+المطلوب الأول المطلوب التانى من نفس ال factor of
+
+226
+00:27:17,990 --> 00:27:21,230
+safety في حال كان ال load is repeatedly applied
+
+227
+00:27:24,970 --> 00:27:31,750
+المطلوب التاني ب .. ال load repeatedly applied
+
+228
+00:27:31,750 --> 00:27:37,310
+يعني بتغير بين zero و maximum value ألف ال F
+
+229
+00:27:37,310 --> 00:27:46,310
+minimum بالساوية zero وال F maximum بالساوية الف
+
+230
+00:27:46,310 --> 00:27:51,470
+pound في الحلقة دي هنحس أنه هيطلع عند ال F mean
+
+231
+00:27:52,900 --> 00:28:01,220
+بيستوي F alternating بيستوي الف على اتنين بيطلع
+
+232
+00:28:01,220 --> 00:28:08,540
+خمسمية pound الحسب
+
+233
+00:28:08,540 --> 00:28:20,390
+انا KF هسه واحد زاد Q في KT minus واحدالـ Q في
+
+234
+00:28:20,390 --> 00:28:23,290
+حالة الcast iron نعتبرها ايه في الساوية اتنين من
+
+235
+00:28:23,290 --> 00:28:27,970
+عشرة حتسة واحد زاد اتنين من عشرة في كتي اللي هي
+
+236
+00:28:27,970 --> 00:28:35,590
+اتنين point اربع خمسة ناقص واحد حتطلع
+
+237
+00:28:35,590 --> 00:28:35,590
+واحد point
+
+238
+00:28:48,790 --> 00:28:58,730
+أتنين نقل اتنين تسعة ستكون
+
+239
+00:28:58,730 --> 00:29:07,530
+دي sigma a سواء sigma M سواء KF في
+
+240
+00:29:07,530 --> 00:29:11,190
+اللي
+
+241
+00:29:11,190 --> 00:29:17,280
+هي F mean أو F alternating على ال areaيعني هتكون
+
+242
+00:29:17,280 --> 00:29:23,280
+الكافي عندي واحد point اتنين تسعة في ال FM 500 وال
+
+243
+00:29:23,280 --> 00:29:29,680
+A عندي point اتنين point اتنين تمانية واحد اتنين
+
+244
+00:29:29,680 --> 00:29:30,760
+خمسة
+
+245
+00:29:35,840 --> 00:29:42,420
+عندى one point اتنين تسعة في خمسمية تقسيم point
+
+246
+00:29:42,420 --> 00:29:50,820
+اتنين تمانية واحد اتنين خمسة في ساوي تطلع اتنين
+
+247
+00:29:50,820 --> 00:29:56,120
+point تسعة
+
+248
+00:29:56,120 --> 00:30:01,600
+تلاتة kilo pound per square inch الان بنجى بنعمل
+
+249
+00:30:01,600 --> 00:30:02,400
+plot هنا
+
+250
+00:30:05,290 --> 00:30:10,890
+هتكون نقطة هذه اللي
+
+251
+00:30:10,890 --> 00:30:16,050
+هي عندك اتنين point اتنين تسعة تلاتة و اتنين point
+
+252
+00:30:16,050 --> 00:30:18,690
+اتنين تسعة تلاتة احنا في first quadrant هذا ال
+
+253
+00:30:18,690 --> 00:30:29,040
+load line هذا ال load line في الحالة هذه Rبساوة
+
+254
+00:30:29,040 --> 00:30:37,040
+sigma a ع sigma m بساوة واحد في حال انا كنت في ال
+
+255
+00:30:37,040 --> 00:30:49,340
+first quadrant بستخدم المعادلة اللي هي SA بساوة
+
+256
+00:30:49,340 --> 00:30:53,620
+RSUT زائد SE
+
+257
+00:31:00,910 --> 00:31:08,790
+زائد SE على اتنين في minus واحد زائد جزر التربيع
+
+258
+00:31:08,790 --> 00:31:24,510
+لواحد زائد اربعة R S U T SE على R S U T زائد SE
+
+259
+00:31:24,510 --> 00:31:31,270
+لكل تربيعلحظة ان احنا ال SE لحد تاني ما جيبناهاش
+
+260
+00:31:31,270 --> 00:31:36,130
+احنا حكينا ال K A و ال K B included معناته هتكون
+
+261
+00:31:36,130 --> 00:31:45,010
+عنده ال SE هتكون سوى K A K B SE prime هذه included
+
+262
+00:31:45,010 --> 00:31:50,730
+في KC يعني هتكون عنده انا already طلعت اللي هي SE
+
+263
+00:31:50,730 --> 00:31:57,170
+prime اللي هي اربعتاش في KC تسعة من عشرةأنا هكون
+
+264
+00:31:57,170 --> 00:32:04,890
+اربعة طرف تسعة و ناشرة بطلع
+
+265
+00:32:04,890 --> 00:32:12,050
+اتناش point ستة kilo pound per square inch معناته
+
+266
+00:32:12,050 --> 00:32:19,490
+ال S A هتكون تساوي ال R عندي واحد ال S U T عندي
+
+267
+00:32:19,490 --> 00:32:29,340
+واحد تلاتينزائد اتناش point ستة على اتنين في minus
+
+268
+00:32:29,340 --> 00:32:35,240
+واحد زائد جزر التربيع لواحد زائد اربعة R اللي هي
+
+269
+00:32:35,240 --> 00:32:40,320
+واحد في ال SUT واحد وتلاتين في ال SE اتناش point
+
+270
+00:32:40,320 --> 00:32:47,840
+ستة على اللي هي واحد تلاتين زائد اتناش point ستة
+
+271
+00:32:47,840 --> 00:32:50,120
+لكل تربيع
+
+272
+00:32:59,970 --> 00:33:09,090
+هتطلع اربعة في واحد تلاتين في اتناش point ستة
+
+273
+00:33:09,090 --> 00:33:16,250
+تقسيم تلاتة
+
+274
+00:33:16,250 --> 00:33:20,670
+في تلاتين point ستة تقسيم
+
+275
+00:33:23,040 --> 00:33:34,440
+ستة يساوي زائد واحد تحت الجزر المهم بنحسبها تطلع
+
+276
+00:33:34,440 --> 00:33:42,800
+عندنا الاش بنحسب ال S A ال
+
+277
+00:33:42,800 --> 00:33:45,600
+S A هتطلع عندي سبعة اربعين ستة تلاتة
+
+278
+00:33:49,150 --> 00:33:54,890
+kilo pound per square inch ومنها بحث بال factor of
+
+279
+00:33:54,890 --> 00:34:01,850
+safety انه هيكون الساوى S A على Sigma A S A اللي
+
+280
+00:34:01,850 --> 00:34:10,470
+هي سبعة point ستة تلاتة على Sigma
+
+281
+00:34:10,470 --> 00:34:16,090
+A اللي هي احنا حسبناها اتنين point اتنين تسعة
+
+282
+00:34:16,090 --> 00:34:16,890
+تلاتة
+
+283
+00:34:29,380 --> 00:34:34,700
+تطلع تلاتة بقون تلاتة اتنين تمانية تلاتة بقون
+
+284
+00:34:34,700 --> 00:34:38,440
+تلاتة اتنين تمانية ال factor of safety هذه الحالة
+
+285
+00:34:38,440 --> 00:34:41,960
+التانية ال
+
+286
+00:34:41,960 --> 00:34:46,560
+case التالتة ال
+
+287
+00:34:46,560 --> 00:34:53,840
+case التالتة ال load fluctuates between minus one
+
+288
+00:34:53,840 --> 00:34:58,180
+thousand and three hundred pounds حالة التالتة
+
+289
+00:35:12,150 --> 00:35:19,630
+الحالة التالتة ال load بترجح بين ناقص الف و
+
+290
+00:35:19,630 --> 00:35:31,510
+تلاتمية pound يعني F minimum F
+
+291
+00:35:31,510 --> 00:35:40,780
+minimum بيصبح minus الف poundو F maximum بالساوية
+
+292
+00:35:40,780 --> 00:35:49,420
+تلاتمية pound معناته ال F mean هتكون ساوية minus
+
+293
+00:35:49,420 --> 00:35:58,420
+الف زائد تلاتمية على اتنين يعني minus سبعمية على
+
+294
+00:35:58,420 --> 00:36:05,960
+اتنين ماقص تلاتمية و خمسين pound وال F alternating
+
+295
+00:36:08,200 --> 00:36:17,820
+هيكون تلاتمية ناقص ناقص الف على اتنين يعني هيكون
+
+296
+00:36:17,820 --> 00:36:30,540
+الف تلاتمية على اتنين ستمية و خمسين found من
+
+297
+00:36:30,540 --> 00:36:40,070
+هنا بنحسب ال sigma M سواء KFفى FM على الـ Area
+
+298
+00:36:40,070 --> 00:36:46,930
+الكاف الرودي احنا حسبنا واحد point اتنين تسعة فى
+
+299
+00:36:46,930 --> 00:36:59,830
+ال FM تلتمية وخمسين سالب تلتمية وخمسين ع
+
+300
+00:36:59,830 --> 00:37:06,390
+ال Area على point اتنين تمانية واحد اتنين خمسة
+
+301
+00:37:07,430 --> 00:37:16,630
+هتكون سالب واحد
+
+302
+00:37:16,630 --> 00:37:26,390
+point اتنين تسعة في تلت مية و خمسين تقسيم point
+
+303
+00:37:26,390 --> 00:37:30,910
+اتنين تمانية واحد اتنين خمسة بيطلع واحد point
+
+304
+00:37:30,910 --> 00:37:36,270
+ستمية و خمسين minus واحد kilo pound per square
+
+305
+00:37:36,270 --> 00:37:45,290
+inchالـ Sigma alternating هتكون سوى KF في F
+
+306
+00:37:45,290 --> 00:37:54,510
+alternating على ال area أو بيسوى Sigma M بيسوى
+
+307
+00:37:54,510 --> 00:38:06,070
+Sigma M على FM في F alternating هي هي هي هتكون
+
+308
+00:38:06,920 --> 00:38:07,460
+1
+
+309
+00:38:07,460 --> 00:38:19,780
+.605ﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻﻻ�
+
+310
+00:38:41,440 --> 00:38:45,560
+تطلع اتنين بون تسعة تمانية واحد اتنين بون تسعة
+
+311
+00:38:45,560 --> 00:38:54,940
+تمانية واحد كيلو pound per square inch نجي نعمل
+
+312
+00:38:54,940 --> 00:39:02,060
+plot طبعا عند ال sigma mean سالب sigma mean سالب
+
+313
+00:39:02,060 --> 00:39:07,080
+اللي
+
+314
+00:39:07,080 --> 00:39:12,780
+هي ناقصواحد point ستمية وخمس فانات وانا في ال
+
+315
+00:39:12,780 --> 00:39:18,640
+second quadrant و ال sigma alternating اللي هي
+
+316
+00:39:18,640 --> 00:39:23,600
+اتنين point تسعة تمانية واحد طبعا هذا ال load line
+
+317
+00:39:23,600 --> 00:39:29,220
+وهذا
+
+318
+00:39:29,220 --> 00:39:37,720
+ال failure line هذا هتكون S alternating وهذا هتكون
+
+319
+00:39:40,230 --> 00:39:50,770
+S M و ال R سيكون سيجما alternating على سيجما M
+
+320
+00:39:50,770 --> 00:39:57,150
+بالساوي اللي هو اتنين point تسعة تمانية واحد على
+
+321
+00:39:57,150 --> 00:40:05,290
+minus واحد point ستة سفر خمسة عشان
+
+322
+00:40:05,290 --> 00:40:08,810
+نحسب احنا في second quadrant ستكون ال S A
+
+323
+00:40:18,750 --> 00:40:29,330
+الـ ال S A بتساوي
+
+324
+00:40:29,330 --> 00:40:33,570
+S E زائد
+
+325
+00:40:33,570 --> 00:40:41,370
+S E على S U T minus واحد
+
+326
+00:40:45,570 --> 00:40:55,430
+في S M طبعا
+
+327
+00:40:55,430 --> 00:41:06,710
+ال R مش سوى S A برضه على S M يعني
+
+328
+00:41:06,710 --> 00:41:10,610
+مش
+
+329
+00:41:10,610 --> 00:41:22,150
+سوى Rمعناته عنده الـ S M بسوا S A على R يعني هذه
+
+330
+00:41:22,150 --> 00:41:31,550
+المعادة اللي حاسبها عندى S A بسوا S E زائد S E على
+
+331
+00:41:31,550 --> 00:41:41,290
+S U T minus واحد في S A على R ومنها بحسب الـ S A
+
+332
+00:41:42,260 --> 00:41:47,960
+بحث في ال S A هتطلع ال
+
+333
+00:41:47,960 --> 00:41:54,500
+S A هتطلع طمنتاش و نص كيلو
+
+334
+00:41:54,500 --> 00:41:59,640
+pound per square inch معناته هيكون عندي طمنتاش و
+
+335
+00:41:59,640 --> 00:42:05,920
+نص كيلو pound per square inch معناته الفاكره ال
+
+336
+00:42:05,920 --> 00:42:13,160
+safety N هيكون الساوي S Aعلى الـ Sigma A الـ S A
+
+337
+00:42:13,160 --> 00:42:19,980
+اللي هي اللي هي تمانتاش
+
+338
+00:42:19,980 --> 00:42:26,000
+و نص على ال Sigma A اتنين point تسعة تمانية واحد
+
+339
+00:42:26,000 --> 00:42:32,220
+تمانتاش
+
+340
+00:42:32,220 --> 00:42:38,760
+و نص تقسيم اتنين point تسعة تمانية واحد تلعب ستة
+
+341
+00:42:38,760 --> 00:42:39,560
+point اتنين
+
+342
+00:42:43,700 --> 00:42:49,300
+ستة bond اتنين سفر ستة factor of six هيك يكون
+
+343
+00:42:49,300 --> 00:42:50,820
+خلصنا المسألة
+
+344
+00:43:52,480 --> 00:43:58,200
+انكمل على موضوع جديد نشوف اللي هو مصطلح دي اللي هو
+
+345
+00:43:58,200 --> 00:44:03,080
+torsional fatigue strength احنا
+
+346
+00:44:03,080 --> 00:44:06,540
+ناخد بعض الملاحظات اولا اذا عندي steady stress
+
+347
+00:44:06,540 --> 00:44:09,280
+component has no effect on the endurance limit for
+
+348
+00:44:09,280 --> 00:44:12,660
+torsional loading if the material اذا كان عندي ال
+
+349
+00:44:12,660 --> 00:44:18,260
+torsional load is steady مش هيكون له تأثير على ال
+
+350
+00:44:18,260 --> 00:44:22,960
+endurance limitفي حال ال material كانت دكتايل
+
+351
+00:44:22,960 --> 00:44:30,140
+polished خالية من الخدوش و المقطعتها مدور يعني في
+
+352
+00:44:30,140 --> 00:44:35,840
+حال كانت ال material دكتايل polished خالية من
+
+353
+00:44:35,840 --> 00:44:44,680
+الخدوش و مقطعتها مدور في الحالة هذهو كان ال .. ال
+
+354
+00:44:44,680 --> 00:44:45,880
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+355
+00:44:45,880 --> 00:44:46,020
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+356
+00:44:46,020 --> 00:44:46,480
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+357
+00:44:46,480 --> 00:44:47,120
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+358
+00:44:47,120 --> 00:44:47,420
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+359
+00:44:47,420 --> 00:44:47,420
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+360
+00:44:47,420 --> 00:44:52,360
+.. ال .. ال .. ال .. ال .. ال ..
+
+361
+00:44:52,360 --> 00:44:55,960
+ال ..
+
+362
+00:44:55,960 --> 00:44:57,900
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+363
+00:44:57,900 --> 00:44:57,940
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+364
+00:44:57,940 --> 00:44:57,980
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+365
+00:44:57,980 --> 00:44:57,980
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+366
+00:44:57,980 --> 00:44:58,040
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+367
+00:44:58,040 --> 00:45:03,640
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+368
+00:45:03,640 --> 00:45:08,540
+ال ..
+
+369
+00:45:13,090 --> 00:45:17,850
+for less than perfect surfaces يعني ال surface ما
+
+370
+00:45:17,850 --> 00:45:25,310
+كان polished و ممكن كان فيه notches the modified
+
+371
+00:45:25,310 --> 00:45:27,670
+godman line is more reasonable الحالة دي نستخدم
+
+372
+00:45:27,670 --> 00:45:32,610
+modified godman linefor pure torsion cases في حالة
+
+373
+00:45:32,610 --> 00:45:36,410
+عندى ال mechanical member متعرض ل pure torsion
+
+374
+00:45:36,410 --> 00:45:42,570
+بنستخدم ال KC 0.59 to convert normal endurance
+
+375
+00:45:42,570 --> 00:45:45,430
+strength to sheer endurance strength يعني انا عندى
+
+376
+00:45:45,430 --> 00:45:49,930
+SE وفي
+
+377
+00:45:49,930 --> 00:45:54,670
+عندى SES
+
+378
+00:45:54,670 --> 00:45:57,730
+عشان احسب ال SES
+
+379
+00:46:02,670 --> 00:46:08,990
+الـ SE س هتكون point خمسة تسعة في ال SE ال normal
+
+380
+00:46:08,990 --> 00:46:15,770
+for shear ان احنا .. احنا عندنا في حالة ال tensile
+
+381
+00:46:15,770 --> 00:46:21,130
+loading عندنا ال SUT في حالة ال shear عندنا يقبلها
+
+382
+00:46:21,130 --> 00:46:29,130
+اللي هو ال shear ultimate strength SSU ال SSU
+
+383
+00:46:31,280 --> 00:46:41,020
+بالساوية point 6 7 S U T يعني
+
+384
+00:46:41,020 --> 00:46:45,680
+في حالة torsional fatigueloading it is reasonable
+
+385
+00:46:45,680 --> 00:46:51,360
+to use modified Godman line استخدم KC to convert
+
+386
+00:46:51,360 --> 00:46:55,160
+from normal endurance strength to sheer endurance
+
+387
+00:46:55,160 --> 00:47:00,760
+strength هتكون ال SE S بسبب وانت خمسة تسعة SE و
+
+388
+00:47:00,760 --> 00:47:05,320
+convert ال .. يعني بدك تحول من ultimate tensile
+
+389
+00:47:05,320 --> 00:47:08,880
+strength ل sheer ultimate strength اللي هو SSU
+
+390
+00:47:08,880 --> 00:47:10,560
+بسبب وانت ستة سبعة SUT
+
+391
+00:47:14,630 --> 00:47:21,290
+طيب نيجي لل combinations of loading modes for
+
+392
+00:47:21,290 --> 00:47:24,590
+combined loading condition combined loading يعني
+
+393
+00:47:24,590 --> 00:47:27,790
+ممكن يكون عندي axial loading مع bending loading مع
+
+394
+00:47:27,790 --> 00:47:31,750
+torsional loading هنستخدم ال distortion energy
+
+395
+00:47:31,750 --> 00:47:37,850
+theorem to combine them يعني هنحسب von Mises
+
+396
+00:47:37,850 --> 00:47:42,350
+stress so one can alternating von Mises او mid
+
+397
+00:47:42,350 --> 00:47:43,390
+range von Mises
+
+398
+00:47:46,760 --> 00:47:54,320
+then we apply KF to each type of stress في حالة ال
+
+399
+00:47:54,320 --> 00:47:58,100
+load factor use KC جوه المعادلة
+
+400
+00:48:01,730 --> 00:48:05,270
+The torsion load factor Kc equal point five nine
+
+401
+00:48:05,270 --> 00:48:08,190
+is inherently included in the von Mises equations
+
+402
+00:48:08,190 --> 00:48:13,550
+سنستخدم المعادلات التالية sigma prime A هي von
+
+403
+00:48:13,550 --> 00:48:16,290
+Mises alternating وعندي معادلة sigma prime M هي
+
+404
+00:48:16,290 --> 00:48:23,130
+von Mises mean طبعا تفاصيلها بتساوي Kf due to
+
+405
+00:48:23,130 --> 00:48:27,670
+bendingفي sigma alternating due to bending زاد كف
+
+406
+00:48:27,670 --> 00:48:31,910
+كف due to axial loading في sigma alternating due
+
+407
+00:48:31,910 --> 00:48:34,910
+to axial loading على point eight five الكل تربية
+
+408
+00:48:34,910 --> 00:48:40,730
+يعني ال course ده بيحتوي كل ال normal stress due
+
+409
+00:48:40,730 --> 00:48:46,230
+to bending و due to axial loading لاحظ ال stress
+
+410
+00:48:46,230 --> 00:48:49,130
+concentration effect is included for both bending
+
+411
+00:48:49,130 --> 00:48:51,710
+and for both axial loading
+
+412
+00:48:57,130 --> 00:49:04,790
+زائد تلاتة KFS اللي هو fatigue concentration
+
+413
+00:49:04,790 --> 00:49:09,150
+factor due to torsion في tau alternating اللي هو
+
+414
+00:49:09,150 --> 00:49:12,790
+alternating shear stress component لكل تربيع قص نص
+
+415
+00:49:12,790 --> 00:49:17,010
+نفس المعادلة في حالةال ال ال ال ال ال ال ال ال ال
+
+416
+00:49:17,010 --> 00:49:17,670
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+417
+00:49:17,670 --> 00:49:20,090
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+418
+00:49:20,090 --> 00:49:25,150
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+419
+00:49:25,150 --> 00:49:26,970
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+420
+00:49:26,970 --> 00:49:27,350
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+421
+00:49:27,350 --> 00:49:29,190
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+422
+00:49:29,190 --> 00:49:29,490
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+423
+00:49:29,490 --> 00:49:29,490
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+424
+00:49:29,490 --> 00:49:29,870
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+425
+00:49:29,870 --> 00:49:29,910
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+426
+00:49:29,910 --> 00:49:29,910
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+427
+00:49:29,910 --> 00:49:29,910
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+428
+00:49:29,910 --> 00:49:33,750
+ال ال ال ال ال ال ال ال ال ال ال ال
+
+429
+00:49:47,970 --> 00:49:52,270
+distortion energy theory still applies for check
+
+430
+00:49:52,270 --> 00:49:58,670
+against yielding يعني انا في الأول في حالة يعني
+
+431
+00:49:58,670 --> 00:50:02,590
+انا بحسب sigma عندما اللي أخدت modified godman
+
+432
+00:50:02,590 --> 00:50:12,610
+modified godman جاء بين جاء بين ال sut و ال sa انا
+
+433
+00:50:12,610 --> 00:50:18,960
+هحسب sigma primemain و sigma prime alternating
+
+434
+00:50:18,960 --> 00:50:22,720
+وهذا
+
+435
+00:50:22,720 --> 00:50:30,040
+ال load line هذا ال load line بنفس المنطقة بحسب
+
+436
+00:50:30,040 --> 00:50:38,240
+sigma sm وبحسب
+
+437
+00:50:39,890 --> 00:50:46,970
+S A و ال factor of safety N F بالساوية بالساوية
+
+438
+00:50:46,970 --> 00:50:55,250
+اللي هو S M على Sigma M Prime بالساوية S A على
+
+439
+00:50:55,250 --> 00:50:58,830
+Sigma A Prime ممكن افحص against yielding هنا عندي
+
+440
+00:50:58,830 --> 00:51:04,670
+S Y و هنا S
+
+441
+00:51:04,670 --> 00:51:05,230
+Y
+
+442
+00:51:08,080 --> 00:51:15,780
+بالحالة هذه هحسب SM due to yielding و SA due to
+
+443
+00:51:15,780 --> 00:51:18,300
+yielding هنرجع لل tables اللي ذكرناهم في هذا ال
+
+444
+00:51:18,300 --> 00:51:29,640
+chapter السابق الآن
+
+445
+00:51:29,640 --> 00:51:35,430
+to check against yielding بدي احسب ال maximumVon
+
+446
+00:51:35,430 --> 00:51:40,430
+Mises Stress بحث في ال maximum Von Mises Stress
+
+447
+00:51:40,430 --> 00:51:43,270
+يعني من المعادلة هذه sigma prime maximum بيستوى
+
+448
+00:51:43,270 --> 00:51:49,050
+sigma a زي sigma M لكل تربيع زي تلاتة تاو a زي تاو
+
+449
+00:51:49,050 --> 00:51:53,250
+M لكل تربيع اقصد نص ومنها بحث في الانواع بيستوى SY
+
+450
+00:51:53,250 --> 00:51:58,680
+على sigma maximum primeأو بعمل approximation بحكي
+
+451
+00:51:58,680 --> 00:52:02,360
+ال sigma prime maximum بالسواء sigma prime a زي
+
+452
+00:52:02,360 --> 00:52:05,740
+sigma prime m يعني اختصار .. يعني تقريبا مش .. مش
+
+453
+00:52:05,740 --> 00:52:08,620
+ميومية صح بس يعني إلى حد ما بتعطينا دقة مناسبة
+
+454
+00:52:08,620 --> 00:52:11,800
+اللي هي sigma prime maximum بالسواء sigma prime a
+
+455
+00:52:11,800 --> 00:52:22,900
+زي sigma prime m طيب
+
+456
+00:52:22,900 --> 00:52:24,860
+خلينا نحل example
+
+457
+00:52:33,130 --> 00:52:43,150
+A rotating shaft is made of 42 x 4 mm AISI 1018
+
+458
+00:52:43,150 --> 00:52:48,550
+cold drawn steel أولا الشيء ال material بتاعته ال
+
+459
+00:52:48,550 --> 00:52:58,870
+material AISI 1018 cold drawn steel
+
+460
+00:53:05,980 --> 00:53:20,380
+الـ shaft عبارة عن ال tube ال tube قطرها
+
+461
+00:53:20,380 --> 00:53:26,180
+الخارجي اتنين
+
+462
+00:53:26,180 --> 00:53:34,200
+و اربعين ملي و ال thickness بتاعها اربعة ملي
+
+463
+00:53:38,800 --> 00:53:44,740
+and has a six millimeter diameter hole draw
+
+464
+00:53:44,740 --> 00:53:55,920
+transverse يعني فيه hole قطر
+
+465
+00:53:55,920 --> 00:54:01,320
+ال hole ستة
+
+466
+00:54:01,320 --> 00:54:01,640
+millimeter
+
+467
+00:54:08,060 --> 00:54:13,060
+estimate the factor of safety guarding against
+
+468
+00:54:13,060 --> 00:54:18,880
+fatigue and static failures using the Gerber and
+
+469
+00:54:18,880 --> 00:54:21,740
+Langer failure criterion for the following loading
+
+470
+00:54:21,740 --> 00:54:24,720
+conditions من ناحية ال factor of safety guarding
+
+471
+00:54:24,720 --> 00:54:28,760
+against fatigue loading guarding against yielding
+
+472
+00:54:28,760 --> 00:54:32,500
+طبعا في حالة ال fatigue loading هستخدم ال gerber
+
+473
+00:54:32,500 --> 00:54:43,660
+criteria أول حالة case athe shaft case a the
+
+474
+00:54:43,660 --> 00:54:47,220
+shaft is subjected to a completely reversed torque
+
+475
+00:54:47,220 --> 00:54:54,860
+completely reversed torque يعني عندي ال torque
+
+476
+00:54:54,860 --> 00:54:59,320
+minimum بالسواء
+
+477
+00:54:59,320 --> 00:55:05,380
+ناقص مائة و عشرين نيوتر متر وال
+
+478
+00:55:05,380 --> 00:55:09,760
+torque maximumبس هو مية و عشرين نيوتن متر يعني
+
+479
+00:55:09,760 --> 00:55:16,840
+بتروح بين negative و positive in phase with a
+
+480
+00:55:16,840 --> 00:55:21,360
+completely reversed bending in phase with a
+
+481
+00:55:21,360 --> 00:55:25,080
+completely reversed bending وعندي bending كمان M
+
+482
+00:55:25,080 --> 00:55:33,600
+minimum so minus مية و خمسين نيوتن متر وال bending
+
+483
+00:55:33,600 --> 00:55:43,030
+maximum M maximum so مية و خمسينالنيوتن متر المعنى
+
+484
+00:55:43,030 --> 00:55:51,430
+في الحالة هذه هيكون عنده التاو او التيمين بتساوي
+
+485
+00:55:51,430 --> 00:55:58,940
+سفرو ال T alternating بالسواء مية و عشرين نيوتن
+
+486
+00:55:58,940 --> 00:56:06,820
+متر و نفس الأشياء ال M mean بالسواء سفر و ال M
+
+487
+00:56:06,820 --> 00:56:17,620
+alternating بالسواء مية و خمسين نيوتن متر طعم
+
+488
+00:56:17,620 --> 00:56:22,570
+الزمن انا في عندى two stressوعند stress
+
+489
+00:56:22,570 --> 00:56:26,070
+concentration لان هنروح على الجداول
+
+490
+00:56:58,690 --> 00:57:10,090
+هنستخدم اللي هو appendix A16 اه A16 هاي A16 فيه
+
+491
+00:57:10,090 --> 00:57:15,210
+عندى tube اللي لها القطر الخارجي و القطر الداخلي و
+
+492
+00:57:15,210 --> 00:57:21,990
+فيه ثقب مستعرض فيه ثقب مستعرض هذا في حالة ال .. ال
+
+493
+00:57:21,990 --> 00:57:22,530
+.. ال bending
+
+494
+00:57:25,760 --> 00:57:32,520
+الان احنا المعطيات اللي معطينا إياها ال A نطلع
+
+495
+00:57:32,520 --> 00:57:40,660
+الشكل ال A اللي
+
+496
+00:57:40,660 --> 00:57:47,580
+هي الثقب اللي هي ستة ميلي و
+
+497
+00:57:47,580 --> 00:57:48,820
+ال D capital
+
+498
+00:57:52,540 --> 00:57:57,640
+اللي هي اتنين و اربعين ملي والقطر الداخل دي small
+
+499
+00:57:57,640 --> 00:58:01,040
+دي
+
+500
+00:58:01,040 --> 00:58:05,460
+capital او القطر الخارجي القطر الداخل هيكون اتنين
+
+501
+00:58:05,460 --> 00:58:08,720
+و اربعين ناقص اربع ناقص اربع هيكون اتنين و اربعين
+
+502
+00:58:08,720 --> 00:58:15,720
+ناقص تمانية يعني هيكون اربع تلاتين ملي متر
+
+503
+00:58:23,030 --> 00:58:30,770
+هو الـ Sigma O بتساوي
+
+504
+00:58:30,770 --> 00:58:44,070
+M على ال section modulus على ال Z net الـ
+
+505
+00:58:44,070 --> 00:58:46,130
+M ال
+
+506
+00:58:49,840 --> 00:58:57,160
+في الجدول التحت معطيني عندي a على d بالزمن a على D
+
+507
+00:58:57,160 --> 00:59:14,160
+capital اللي هي 6 على 42 تطلع
+
+508
+00:59:14,160 --> 00:59:15,560
+point 1,4,3
+
+509
+00:59:24,400 --> 00:59:27,580
+ومعطينا different values for D على D انا D على D
+
+510
+00:59:27,580 --> 00:59:34,060
+اكم عنده D على D الفعلية اللى عندى D small على D
+
+511
+00:59:34,060 --> 00:59:38,720
+capital اللى هى اربعة وتلاتين على اتنين واربعين
+
+512
+00:59:38,720 --> 00:59:51,980
+اربعة تلاتين تطلع
+
+513
+00:59:51,980 --> 01:00:04,940
+point تمانيةبونت تمانية واحد بونت تمانية تقريبا
+
+514
+01:00:04,940 --> 01:00:13,980
+من
+
+515
+01:00:13,980 --> 01:00:18,580
+الجدول هذا هحسب ال a و ال kt اللي انا عندي اللي هو
+
+516
+01:00:18,580 --> 01:00:23,520
+a على d اللي هو بنت واحد اربعةاللي هي هتكون في
+
+517
+01:00:23,520 --> 01:00:38,700
+المنطقة هذه هي
+
+518
+01:00:38,700 --> 01:00:47,780
+عندي هنا point واحد اربعة تلاتة و D small على D
+
+519
+01:00:47,780 --> 01:00:49,200
+كبت هنا عندي تسعة من عشرة
+
+520
+01:00:52,610 --> 01:00:57,290
+وهنا عندي ستة من عشرة أنا التمام من عشرة جاي بين
+
+521
+01:00:57,290 --> 01:01:03,410
+الاتنين هدول و التمام من عشرة جاي وين؟ بينهم
+
+522
+01:01:03,410 --> 01:01:08,130
+معناته محتاج اعمل double interpolation double
+
+523
+01:01:08,130 --> 01:01:11,890
+interpolation يعني ال interpolation الأول يعني
+
+524
+01:01:11,890 --> 01:01:16,530
+هجيب عن d capital دي small عن d capital عن تسعة من
+
+525
+01:01:16,530 --> 01:01:18,030
+عشرة دي small
+
+526
+01:01:21,030 --> 01:01:26,790
+على دي capital هي عندي تسعة من عشرة وهي عندي ستة
+
+527
+01:01:26,790 --> 01:01:35,890
+من عشرة هحسب
+
+528
+01:01:35,890 --> 01:01:42,470
+ال A وال
+
+529
+01:01:42,470 --> 01:01:42,910
+KT
+
+530
+01:01:52,610 --> 01:01:56,910
+طيب ال interpolation ال A الأولى اللى هتكون خلانا
+
+531
+01:01:56,910 --> 01:02:01,870
+ندعم الواحدة و الباقية تعملوها لحالكوا ال A اللى
+
+532
+01:02:01,870 --> 01:02:08,110
+جاي هنا يعني فاندي واحدة هنا و واحدة هنا طبعا ال
+
+533
+01:02:08,110 --> 01:02:09,130
+table A 16
+
+534
+01:02:21,860 --> 01:02:25,120
+هتكون ال a الأولانية اللى عند ال a عند التسعة و
+
+535
+01:02:25,120 --> 01:02:29,480
+العشرة هتكون
+
+536
+01:02:29,480 --> 01:02:38,400
+تساوي point 82 زائد
+
+537
+01:02:38,400 --> 01:02:45,480
+point
+
+538
+01:02:45,480 --> 01:02:48,580
+143
+
+539
+01:02:49,370 --> 01:02:56,310
+ناقص bond 1 2 5 خدنا
+
+540
+01:02:56,310 --> 01:03:00,470
+نعمل ال interpolation نعطيك المعادلة العامة Y
+
+541
+01:03:00,470 --> 01:03:12,630
+بيساوي Y واحد زاد X minus X واحد على X2 minus X
+
+542
+01:03:12,630 --> 01:03:19,640
+واحد في Y2 minus Y واحدو الاصل بتاع ال
+
+543
+01:03:19,640 --> 01:03:24,660
+interpolation جاي انا عندي بيكون curve عندي هي
+
+544
+01:03:24,660 --> 01:03:33,020
+النقطة هين هي X وهي Y هين عندي X واحد وهين Y واحد
+
+545
+01:03:33,020 --> 01:03:39,700
+هي النقطة X اتنين وهين Y اتنين بحاول اعمل
+
+546
+01:03:39,700 --> 01:03:43,680
+approximation لل curve بين نقطتين ك linear هذه
+
+547
+01:03:43,680 --> 01:03:46,620
+النقطة هتكون X وY
+
+548
+01:03:48,770 --> 01:03:55,690
+السلوك بتاع الخطها ده هكون y2-x2 على y1-x1 بيستوي
+
+549
+01:03:55,690 --> 01:04:03,750
+y-y1 على x-x1 و بعدين تعمل شغل جبر و بتحسب تحكي ال
+
+550
+01:04:03,750 --> 01:04:09,710
+y اللي الكمة اللي في النص بيستوي y1 زاد x-x1 على
+
+551
+01:04:09,710 --> 01:04:16,790
+y2-y1 على x2-x1 طيب based on this equation هتكون
+
+552
+01:04:16,790 --> 01:04:25,980
+ال aعندى تسعة من عشرة بتساوي الى Y1 بونت تمانية
+
+553
+01:04:25,980 --> 01:04:32,540
+اتنين زاد بونت واحد اربعة تلاتة minus بونت واحد
+
+554
+01:04:32,540 --> 01:04:40,180
+اتنين خمسة علىاكس اتنين اللي هي point واحد خمسة
+
+555
+01:04:40,180 --> 01:04:46,220
+ماقص point واحد اتنين خمسة في y اتنين اللي هي
+
+556
+01:04:46,220 --> 01:04:55,580
+point سبعة تسعة minus point تمانية اتنين يعني عند
+
+557
+01:04:55,580 --> 01:05:01,580
+تسعة و عشرة و ال a عند ستة من عشرة تنحسب اللي هي
+
+558
+01:05:01,580 --> 01:05:12,150
+هتكونبونت تمانية اتنين على
+
+559
+01:05:12,150 --> 01:05:20,130
+اي حال ال a هتكون لحظة
+
+560
+01:05:20,130 --> 01:05:24,970
+ال a لا تتغير بين البونت تسعة و البونت ستة هتكون
+
+561
+01:05:24,970 --> 01:05:31,290
+نفسها عند البونت تمانية ال KT
+
+562
+01:05:33,260 --> 01:05:39,840
+عند التسعة من عشرة بتساوي اتنين point اربعة واحد
+
+563
+01:05:39,840 --> 01:05:47,100
+اتنين point اربعة واحد زائد point واحد اربعة تلاتة
+
+564
+01:05:47,100 --> 01:05:52,500
+ناقص point واحد اتنين خمسة على point واحد خمسة
+
+565
+01:05:52,500 --> 01:05:58,120
+ناقص point واحد اتنين خمسة في عند التسعة من عشرة
+
+566
+01:05:58,120 --> 01:06:05,040
+اللي هي اتنين point تلاتة تسعة-2.41 وهي بنحسبها و
+
+567
+01:06:05,040 --> 01:06:14,020
+ال KT عند ال 6 من 10 بتطلع
+
+568
+01:06:15,660 --> 01:06:20,120
+اللي هي اتنين point تلاتة اتنين اتنين point تلاتة
+
+569
+01:06:20,120 --> 01:06:25,180
+اتنين زاد point واحد اربعة تلاتة minus point واحد
+
+570
+01:06:25,180 --> 01:06:31,380
+اتنين خمسة على point واحد خمسة minus point واحد
+
+571
+01:06:31,380 --> 01:06:38,680
+اتنين خمسة في اللي هي اتنين point اتنين تسعة minus
+
+572
+01:06:38,680 --> 01:06:45,630
+اتنين point تلاتة اتنين من اتوا حسبنا ال Aالـ A
+
+573
+01:06:45,630 --> 01:07:09,110
+اللي هي عند ال point واحد نحسبها طيب
+
+574
+01:07:09,110 --> 01:07:14,090
+عشان اخش عسلت نحسب يعني انا صار عندهين قيمةوعندي
+
+575
+01:07:14,090 --> 01:07:20,110
+هنا قيمة لل A وعندي ال KT عند تسعة و عشرة لها قيمة
+
+576
+01:07:20,110 --> 01:07:26,230
+وال KT عند ستة و عشرة لها أيش قيمة الآن أنا بدي ال
+
+577
+01:07:26,230 --> 01:07:30,830
+D على D اللي هي bond تمانية D على D اللي بين
+
+578
+01:07:30,830 --> 01:07:37,500
+التنتين هدول اللي هي bond تمانيةبعمل second
+
+579
+01:07:37,500 --> 01:07:44,380
+interpolation عشان أحسب ال a هنا و أحسب ال kt from
+
+580
+01:07:44,380 --> 01:07:56,180
+اللي هو second interpolation find
+
+581
+01:07:56,180 --> 01:08:00,320
+a
+
+582
+01:08:00,320 --> 01:08:15,980
+و ktهكون عندى ال A كذا و ال KT كذا طيب
+
+583
+01:08:15,980 --> 01:08:20,440
+نرجع،
+
+584
+01:08:20,440 --> 01:08:25,800
+الآن صارت أنا عارف ال A و
+
+585
+01:08:25,800 --> 01:08:30,160
+ال D capital معروف و ال D small معروفة مانعت بحسب
+
+586
+01:08:30,160 --> 01:08:38,530
+ال Z net ال Z netالـ net section modulus Z net
+
+587
+01:08:38,530 --> 01:08:50,630
+بتساوي باي في ايه على اتنين و تلاتين D capital في
+
+588
+01:08:50,630 --> 01:08:56,950
+D أُس أربعة minus D small أُس أربعة
+
+589
+01:09:05,970 --> 01:09:13,870
+و منها باحسب ال sigma alternating
+
+590
+01:09:13,870 --> 01:09:23,710
+A هتكون تساوي M على
+
+591
+01:09:23,710 --> 01:09:30,070
+Z net خلينا نكمل نفس الجدول
+
+592
+01:09:38,300 --> 01:09:44,280
+في الجدول مقسم جزئية جزئية bending وجزئية torsion
+
+593
+01:09:44,280 --> 01:09:50,780
+حالة ال torsion اللي هو هذا الجدول هروح احسب كمان
+
+594
+01:09:50,780 --> 01:09:57,620
+اللي هو ال Janet اللي هو ال ال ال ال polar moment
+
+595
+01:09:57,620 --> 01:10:03,720
+of inertia لل cross section Janet ده هنبروح على
+
+596
+01:10:03,720 --> 01:10:04,220
+Janet
+
+597
+01:10:07,430 --> 01:10:13,170
+بتساوي اللي هي باي في ايه في
+
+598
+01:10:13,170 --> 01:10:18,210
+دي اص اربع minus
+
+599
+01:10:18,210 --> 01:10:23,830
+دي small اص اربع على اتنين و تلاتين
+
+600
+01:10:38,050 --> 01:10:44,790
+وال tau alternating
+
+601
+01:10:44,790 --> 01:10:52,090
+nominal هتكون معطوب العلاقة اللي
+
+602
+01:10:52,090 --> 01:11:00,010
+هي T D capital على
+
+603
+01:11:00,010 --> 01:11:01,710
+2 J net
+
+604
+01:11:07,820 --> 01:11:14,180
+برضه من الجدول هذا .. من الجدول هذا انا
+
+605
+01:11:14,180 --> 01:11:25,420
+a على d انا
+
+606
+01:11:25,420 --> 01:11:26,520
+هكون في المنطقة هذه
+
+607
+01:11:37,710 --> 01:11:42,270
+أنا عند ال هي دي small على دي capital تمام من عشرة
+
+608
+01:11:42,270 --> 01:11:51,430
+موجودة بعمل interpolation عشان أحسب ال a هنا و
+
+609
+01:11:51,430 --> 01:11:56,130
+أحسب ال kt ال
+
+610
+01:11:56,130 --> 01:12:02,330
+a و ال kt يعني
+
+611
+01:12:02,330 --> 01:12:04,830
+مانعته بالزمن أحسب kts
+
+612
+01:12:07,790 --> 01:12:16,410
+بنحسبها من الجدول by linear interpolation طيب،
+
+613
+01:12:16,410 --> 01:12:21,370
+الآن هذه كلها parameters جيومتريكيين
+
+614
+01:12:21,370 --> 01:12:29,490
+لان صرت ان عارف sigma AO و tau AO بتدروح للمعادلات
+
+615
+01:12:36,890 --> 01:12:57,550
+اللي هي ال Von Mises equations بدي
+
+616
+01:12:57,550 --> 01:12:58,070
+أحسب
+
+617
+01:13:09,950 --> 01:13:14,610
+Sigma prime alternating وSigma prime mean احنا في
+
+618
+01:13:14,610 --> 01:13:18,790
+الحالة هذه الـSigma prime mean ستكون صفر حتى عند
+
+619
+01:13:18,790 --> 01:13:21,550
+الـSigma prime alternating الـSigma prime
+
+620
+01:13:21,550 --> 01:13:26,000
+alternating ستكون كف لل bendingفى sigma a للـ
+
+621
+01:13:26,000 --> 01:13:30,040
+bending زي كف اكسل فى sigma a اكسل على point eight
+
+622
+01:13:30,040 --> 01:13:34,080
+five زي تلتة فى KFS torsion فى tau alternating
+
+623
+01:13:34,080 --> 01:13:39,560
+torsion كل تربيع قص نص احنا مش انه axial load انه
+
+624
+01:13:39,560 --> 01:13:45,920
+بس bending معناه هتكون عنده sigma
+
+625
+01:13:45,920 --> 01:13:49,700
+alternating
+
+626
+01:13:49,700 --> 01:13:58,100
+von Mises هتكون KFالـ Sigma alternating nominal
+
+627
+01:13:58,100 --> 01:14:12,700
+لكل تربيع زائد تلاتة في KFS torsion في Tau
+
+628
+01:14:12,700 --> 01:14:18,620
+alternating nominal لكل تربيع كل هذا أص نص
+
+629
+01:14:24,090 --> 01:14:31,990
+طيب احنا روديا حسبنا sigma a nominal و حسبنا tau a
+
+630
+01:14:31,990 --> 01:14:40,890
+nominal ضايل احسب KF و KFS الـ KF بالساوية
+
+631
+01:14:40,890 --> 01:14:51,930
+واحد زاد Q في KT minus واحدالـ KT already حسبتها
+
+632
+01:14:51,930 --> 01:14:58,570
+ضايق الأحسب الـ Q الـ Q من شكل ست عشرين شكل ست
+
+633
+01:14:58,570 --> 01:15:07,610
+عشرين هذا
+
+634
+01:15:07,610 --> 01:15:12,670
+الشكل الـ
+
+635
+01:15:12,670 --> 01:15:16,890
+Notch عنده يعني
+
+636
+01:15:16,890 --> 01:15:21,300
+أكبر الأربعة منه ال wholeو ال SUT ال SUT اين
+
+637
+01:15:21,300 --> 01:15:26,980
+هطلعها ماطينة هو الف و تمانتاش cold drone steel
+
+638
+01:15:26,980 --> 01:15:32,240
+المعنى ان انا هروح على جدول A20 في الكتاب انا هروح
+
+639
+01:15:32,240 --> 01:15:40,540
+على جدول A20 هذا
+
+640
+01:15:40,540 --> 01:15:47,520
+A20 انا عند cold drone الف و تمانتاش
+
+641
+01:15:50,440 --> 01:15:57,660
+هيو الف و طبنتاش call the drone هاي
+
+642
+01:15:57,660 --> 01:16:06,320
+الف و طبنتاش معناته هذا الحديد هذا ال S U T و ال S
+
+643
+01:16:06,320 --> 01:16:15,680
+Y ال من table A20 بتكون
+
+644
+01:16:15,680 --> 01:16:22,910
+عند ال S U T عشان متساوياربعمية و اربعين ميجا
+
+645
+01:16:22,910 --> 01:16:36,370
+باسكال و ال S Y بتساوي تلتمية و سبعين ميجا
+
+646
+01:16:36,370 --> 01:16:46,370
+باسكال هذا ايش ال S U T و ال S Y بروح هرجع على
+
+647
+01:16:46,370 --> 01:16:50,010
+الشكل سبعة عشرين هي ستة عشرين
+
+648
+01:16:56,490 --> 01:17:03,330
+اللي هو ده
+
+649
+01:17:03,330 --> 01:17:21,530
+ال
+
+650
+01:17:21,530 --> 01:17:22,090
+SUT
+
+651
+01:17:25,770 --> 01:17:30,970
+اللي هي أربعمية و أربعين يعني تقريبا هنا يعني
+
+652
+01:17:30,970 --> 01:17:34,130
+تقريبا تطلع ال .. ال .. ال .. ال Q تمانية من عشرة
+
+653
+01:17:34,130 --> 01:17:45,850
+ال Q هتكون ال Q تمانية من عشرة من figure ستة عشرين
+
+654
+01:17:45,850 --> 01:17:54,920
+و منها بحسب ال KF ال KFSبس واحد زاد QS في KTS
+
+655
+01:17:54,920 --> 01:18:00,240
+minus واحد و QS من figure ستة واحد و عشرين الشكل
+
+656
+01:18:00,240 --> 01:18:00,820
+اللي بعده
+
+657
+01:18:16,460 --> 01:18:20,300
+يعني point تمانية point تسعة يعني تقريبا point
+
+658
+01:18:20,300 --> 01:18:26,600
+تمانية تلاتة point تمانية تلاتة
+
+659
+01:18:26,600 --> 01:18:29,560
+figure ستة واحد وعشرين
+
+660
+01:18:34,890 --> 01:18:40,370
+الان احنا سرنا KT معروف عنها و Q طلعناها و KTS
+
+661
+01:18:40,370 --> 01:18:44,690
+معروف عنها و QS طلعناها بحث في ال KF و KFS بعدين
+
+662
+01:18:44,690 --> 01:18:48,830
+بعودة بحث في sigma prime alternating في المعادلة
+
+663
+01:18:48,830 --> 01:18:58,330
+هذه بحث في sigma prime alternating طيب
+
+664
+01:19:04,840 --> 01:19:09,060
+لأنهم بدوا ال factor of safety باستخدام gerber
+
+665
+01:19:09,060 --> 01:19:25,900
+criterion gerber criterion نرجع ال
+
+666
+01:19:25,900 --> 01:19:33,620
+gerber criterion هي ال gerber جاية
+
+667
+01:19:33,620 --> 01:19:34,360
+nonlinear
+
+668
+01:19:36,740 --> 01:19:56,320
+and sigma a and
+
+669
+01:19:56,320 --> 01:19:59,380
+sigma
+
+670
+01:19:59,380 --> 01:20:11,220
+alternating الـ primeعلى SE بالزايد N Sigma M
+
+671
+01:20:11,220 --> 01:20:21,680
+Prime على SUT الكل تربية بالساوية واحد عند هذا ال
+
+672
+01:20:21,680 --> 01:20:28,160
+term مش بيساوي سفر مانا بتحسر عندي N Sigma A Prime
+
+673
+01:20:28,160 --> 01:20:34,880
+على SEبالساوية واحد معناته الان هيكون الساوية SE
+
+674
+01:20:34,880 --> 01:20:52,360
+على Sigma A Prime طيب
+
+675
+01:20:55,530 --> 01:21:00,370
+هذا ال fact of state guarding against yield نروح
+
+676
+01:21:00,370 --> 01:21:05,730
+هنا للجداول هذا الجدول ل Godman هذا الجدول ل
+
+677
+01:21:05,730 --> 01:21:11,070
+Gerber ان حكينا الجدول هذا موجود لنقطة تقاطع هاي
+
+678
+01:21:11,070 --> 01:21:19,470
+ال Gerber S
+
+679
+01:21:19,470 --> 01:21:29,400
+U T و S Eوهي عندي sy
+
+680
+01:21:29,400 --> 01:21:37,540
+وهي ال load line السطر
+
+681
+01:21:37,540 --> 01:21:40,560
+هذا بوجد ليه نقطة تقاطع بين هذا ال load line و
+
+682
+01:21:40,560 --> 01:21:48,040
+gerber line بوجد ليه SM و SA السطر اللي بعده بوجد
+
+683
+01:21:48,040 --> 01:21:50,960
+ليه نقطة تقاطع نقطة تقاطع
+
+684
+01:21:55,160 --> 01:21:58,740
+هنا حكينا احنا .. احنا فش .. هتكون نقطتنا هنا،
+
+685
+01:21:58,740 --> 01:22:03,940
+معناه نقطتنا هنا هيكون عندي ال .. هذا ال N F طبعا
+
+686
+01:22:03,940 --> 01:22:08,660
+ال N Y هيكون
+
+687
+01:22:08,660 --> 01:22:18,520
+S Y على Sigma A Prime
+
+688
+01:22:22,870 --> 01:22:27,410
+واضح هيكون ال ny أكبر من ال nf معناته من المتوقع
+
+689
+01:22:27,410 --> 01:22:31,630
+انه يصير failure by fatigue قبل ما يصير failure by
+
+690
+01:22:31,630 --> 01:22:40,330
+yielding هذا المطلوب الأول المطلوب التاني نرجع
+
+691
+01:22:45,670 --> 01:22:48,670
+The shaft is subjected to a pulsating torque
+
+692
+01:22:48,670 --> 01:22:52,410
+fluctuating from twenty لمية وستين نيوتر متر and a
+
+693
+01:22:52,410 --> 01:22:59,090
+steady bending moment case two الحالة
+
+694
+01:22:59,090 --> 01:23:04,490
+التانية الحالة
+
+695
+01:23:04,490 --> 01:23:12,150
+التانية الشافت متعرض ل torque بتغير ال torque
+
+696
+01:23:12,150 --> 01:23:25,220
+minimumالـ T minimum بتساوي عشرين نيوتن متر وال T
+
+697
+01:23:25,220 --> 01:23:35,360
+maximum بتساوي مية و ستين نيوتن متر وال bending
+
+698
+01:23:35,360 --> 01:23:46,560
+moment is steady يعني ال Mبساوة M main بالساوية
+
+699
+01:23:46,560 --> 01:23:51,940
+150 نيوتن متر معناه في الحالة هذه هيكون عندي ال
+
+700
+01:23:51,940 --> 01:23:58,740
+tau main هيكون عشرين زي المية وستين على اتنين يعني
+
+701
+01:23:58,740 --> 01:24:05,720
+تسعين نيوتن مترالـ T alternating سواء مية و ستين
+
+702
+01:24:05,720 --> 01:24:15,220
+ناقص عشرين على اتنين سبعين نيوتن متر وال M mean
+
+703
+01:24:15,220 --> 01:24:21,660
+سواء مية و خمسين نيوتن متر وال M alternating
+
+704
+01:24:21,660 --> 01:24:31,680
+بالساوية سفر I follow the same procedureهحسب sigma
+
+705
+01:24:31,680 --> 01:24:42,340
+prime alternating نرجع للمعادلات اللي
+
+706
+01:24:42,340 --> 01:24:48,840
+هي KF لل bending طبعا
+
+707
+01:24:48,840 --> 01:24:54,000
+انا في الحالة هذه هتكون هذه صفر صفر هتكون تساوي
+
+708
+01:24:54,000 --> 01:24:57,040
+تلاتة
+
+709
+01:25:00,360 --> 01:25:13,800
+كفاس في tau alternating nominal الكل تربيع كله
+
+710
+01:25:13,800 --> 01:25:23,380
+تحت الجدر و ال sigma prime main هتكون ساوى كف
+
+711
+01:25:23,380 --> 01:25:26,620
+sigma
+
+712
+01:25:26,620 --> 01:25:37,700
+mainنومينال كل تربيع زائد تلاتة في KFS تاومين
+
+713
+01:25:37,700 --> 01:25:43,540
+نومينال كل تربيع الكل اص نص يعني انا عندي هكون
+
+714
+01:25:43,540 --> 01:25:47,600
+عندي sigma alternating born mice sigma prime born
+
+715
+01:25:47,600 --> 01:25:54,920
+mice اللي انا على فرق كتير عند هاي gear barهذه S U
+
+716
+01:25:54,920 --> 01:26:07,480
+T وهذه S E وهذه ال load ال load line هحسب
+
+717
+01:26:07,480 --> 01:26:18,720
+S M و S alternating ومنها بحسب ال N F بالساوية
+
+718
+01:26:18,720 --> 01:26:29,850
+اللي هي S Mعلى sigma M و برضه مستوى S A على sigma
+
+719
+01:26:29,850 --> 01:26:34,750
+A prime هذا
+
+720
+01:26:34,750 --> 01:26:46,470
+في حالة الفتيك في حالة ال yielding في
+
+721
+01:26:46,470 --> 01:26:47,390
+حالة ال yielding
+
+722
+01:26:50,660 --> 01:26:54,140
+بحسب ال S A بسوة R أسواع على واحة زاد R وبعدين
+
+723
+01:26:54,140 --> 01:26:59,740
+بحكي ال factor of safety N بساوة S A على Sigma A
+
+724
+01:26:59,740 --> 01:27:03,020
+Prime هيك بنكون حاليا انا طبعا السؤال طويل كتير
+
+725
+01:27:03,020 --> 01:27:08,070
+بتوقع انكوا تتابعوا الفيديو الكويسو اتحلوا المسائل
+
+726
+01:27:08,070 --> 01:27:12,070
+بالارقام طبعا هذا ال example موجود في الكتاب تقدر
+
+727
+01:27:12,070 --> 01:27:16,730
+تتبعه من الكتاب و تقارنه بين الحل اللي انا حلته و
+
+728
+01:27:16,730 --> 01:27:23,730
+حل الكتاب يعني احنا هنكون متقاربين جدا من .. من
+
+729
+01:27:23,730 --> 01:27:27,990
+بعض احنا هيك بنكون تقريبا غطينا المادة ال machine
+
+730
+01:27:27,990 --> 01:27:31,710
+design واحد حكوا ان ال course ال machine design
+
+731
+01:27:31,710 --> 01:27:34,660
+اتنيناللي هو هكون ال design of mechanical
+
+732
+01:27:34,660 --> 01:27:38,240
+components، هنحكي عن design of shafts، عن design
+
+733
+01:27:38,240 --> 01:27:42,040
+of gears، عن design of springs، عن design of
+
+734
+01:27:42,040 --> 01:27:45,020
+screws، عن design of welding، عن design of
+
+735
+01:27:45,020 --> 01:27:53,600
+sprockets، ال .. ال design of pulleys، يعني هنت ..
+
+736
+01:27:53,600 --> 01:27:56,900
+يعني هكون إشي specific for specific components، دي
+
+737
+01:27:56,900 --> 01:27:57,260
+كل عالم
+
diff --git a/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/GdwYlgLJm0Y_raw.json b/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/GdwYlgLJm0Y_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..41f4fd73e80b54f509ffcff0af379da54bf4bbe9
--- /dev/null
+++ b/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/GdwYlgLJm0Y_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 2851, "start": 4.89, "end": 28.51, "text": "بسم الله الرحمن الرحيم السلام عليكم ورحمة الله وبركاته اليوم هنستكمل الهو failures resulting from static loading المحاضرات الفاتة استعرضتنا اللي هي خارطة الطريق لل .. لل static .. لل failure criterion selection حكينا أول شيء لازم نفحص نشوف المادة هل هي ductile ولا brittle", "tokens": [3555, 38251, 21984, 34892, 5016, 27842, 34892, 5016, 32640, 21136, 37440, 25894, 24793, 4032, 2288, 35571, 3660, 21984, 4032, 26890, 4117, 9307, 3224, 45595, 20498, 8032, 1863, 14851, 24793, 1211, 2423, 3224, 2407, 20774, 16505, 490, 13437, 15114, 9673, 5016, 46958, 2288, 9307, 27188, 9307, 3660, 44713, 3615, 43042, 2655, 8315, 13672, 1829, 39896, 16490, 9640, 9566, 3660, 41950, 16572, 4587, 24976, 4386, 24976, 13437, 4386, 24976, 7763, 46691, 9450, 11331, 4117, 1829, 8315, 5551, 12610, 44049, 38207, 5296, 31377, 2304, 8717, 5172, 5016, 9381, 8717, 8592, 38688, 9673, 18513, 3660, 8032, 1211, 39896, 25954, 794, 49429, 49325], 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بيكون عندى ال .. ال ..", "tokens": [7649, 3224, 4724, 1829, 9381, 13546, 7763, 5296, 15042, 2423, 17842, 6674, 6055, 30544, 1975, 4117, 26890, 1975, 2407, 7251, 3794, 995, 45865, 382, 288, 15844, 568, 4032, 1975, 5016, 8315, 8978, 2423, 4386, 5296, 15042, 9122, 8315, 43242, 7578, 2120, 468, 473, 295, 4244, 9122, 8315, 8717, 5016, 3794, 3794, 12771, 502, 4032, 12771, 568, 4032, 12771, 805, 4032, 34892, 2655, 3555, 16095, 4724, 1829, 5016, 3794, 12771, 502, 1975, 4117, 26890, 9154, 12771, 568, 1975, 4117, 26890, 9154, 12771, 805, 4032, 2423, 17842, 6674, 25961, 7251, 3794, 995, 45865, 382, 12771, 502, 3175, 12771, 568, 6156, 4650, 281, 6674, 24082, 4244, 5261, 4724, 1829, 30544, 43242, 7578, 2423, 4386, 2423, 4386], "avg_logprob": -0.2136787276780396, "compression_ratio": 1.8468085106382979, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 297.92, "end": 298.48, "word": "انه", "probability": 0.60595703125}, {"start": 298.48, "end": 299.04, "word": " بيصير", "probability": 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"end": 1121.41, "word": " خلّيني", "probability": 0.569189453125}, {"start": 1121.41, "end": 1121.95, "word": " أعملها", "probability": 0.8826904296875}, {"start": 1121.95, "end": 1122.51, "word": " بطوطين", "probability": 0.7302734375}], "temperature": 1.0}, {"id": 44, "seek": 115391, "start": 1125.59, "end": 1153.91, "text": "في sigma average تسمى تلاتة تلاتة sigma average تربيع ناقص اتنين in U في تلاتة sigma average تربيع يعني هتكون تساوي تلاتة sigma average تربيع على اتنين E في واحد ناقص اتنين in U", "tokens": [41185, 12771, 4274, 6055, 38251, 7578, 6055, 1211, 9307, 3660, 6055, 1211, 9307, 3660, 12771, 4274, 6055, 2288, 21292, 3615, 8717, 995, 4587, 9381, 1975, 2655, 1863, 9957, 294, 624, 8978, 6055, 1211, 9307, 3660, 12771, 4274, 6055, 2288, 21292, 3615, 37495, 22653, 8032, 2655, 30544, 6055, 3794, 995, 45865, 6055, 1211, 9307, 3660, 12771, 4274, 6055, 2288, 21292, 3615, 15844, 1975, 2655, 1863, 9957, 462, 8978, 36764, 24401, 8717, 995, 4587, 9381, 1975, 2655, 1863, 9957, 294, 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"temperature": 1.0}, {"id": 45, "seek": 117703, "start": 1157.35, "end": 1177.03, "text": "و ال sigma average احنا حكينا بيساوي sigma 1 زي sigma 2 زي sigma 3 على 3 اللي انا اذا بعوض عن sigma average و simplify ال U volume هتعطي بالعلاقة هذه اللي هي واحد ناقص اتنين", "tokens": [2407, 2423, 12771, 4274, 1975, 5016, 8315, 11331, 4117, 1829, 8315, 4724, 1829, 3794, 995, 45865, 12771, 502, 30767, 1829, 12771, 568, 30767, 1829, 12771, 805, 15844, 805, 13672, 1829, 1975, 8315, 1975, 15730, 45030, 2407, 11242, 18871, 12771, 4274, 4032, 20460, 2423, 624, 5523, 8032, 2655, 3615, 9566, 1829, 20666, 3615, 15040, 28671, 29538, 13672, 1829, 39896, 36764, 24401, 8717, 995, 4587, 9381, 1975, 2655, 1863, 9957], "avg_logprob": -0.29393116805864417, "compression_ratio": 1.5460122699386503, "no_speech_prob": 0.0, "words": [{"start": 1157.35, "end": 1157.57, "word": "و", "probability": 0.71533203125}, {"start": 1157.57, "end": 1157.67, "word": " ال", "probability": 0.259033203125}, {"start": 1157.67, 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"start": 2369.05, "end": 2384.51, "text": "distortion energy theory failure occurs when tau maximum أكبر أو يساوي SSY يعني", "tokens": [42649, 8136, 2281, 5261, 7763, 11843, 562, 17842, 6674, 5551, 4117, 26890, 34051, 7251, 3794, 995, 45865, 12238, 56, 37495, 22653], "avg_logprob": -0.42116475918076257, "compression_ratio": 0.9690721649484536, "no_speech_prob": 0.0, "words": [{"start": 2369.05, "end": 2369.91, "word": "distortion", "probability": 0.507843017578125}, {"start": 2369.91, "end": 2370.31, "word": " energy", "probability": 0.89111328125}, {"start": 2370.31, "end": 2370.79, "word": " theory", "probability": 0.8779296875}, {"start": 2370.79, "end": 2371.51, "word": " failure", "probability": 0.6474609375}, {"start": 2371.51, "end": 2374.61, "word": " occurs", "probability": 0.9140625}, {"start": 2374.61, "end": 2376.43, "word": " when", "probability": 0.93212890625}, {"start": 2376.43, "end": 2378.67, "word": " tau", "probability": 0.31689453125}, {"start": 2378.67, "end": 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{"start": 2481.07, "end": 2482.29, "word": " 5SY", "probability": 0.7373046875}, {"start": 2482.29, "end": 2483.07, "word": " في", "probability": 0.8212890625}, {"start": 2483.07, "end": 2483.61, "word": " حالة", "probability": 0.99755859375}, {"start": 2483.61, "end": 2483.77, "word": " ال", "probability": 0.68896484375}, {"start": 2483.77, "end": 2484.17, "word": " distortion", "probability": 0.97705078125}, {"start": 2484.17, "end": 2484.59, "word": " energy", "probability": 0.95458984375}, {"start": 2484.59, "end": 2484.93, "word": " theory", "probability": 0.7080078125}, {"start": 2484.93, "end": 2485.29, "word": " بيساوي", "probability": 0.96796875}, {"start": 2485.29, "end": 2485.83, "word": " bond", "probability": 0.943359375}, {"start": 2485.83, "end": 2489.27, "word": " 577SY", "probability": 0.896484375}], "temperature": 1.0}, {"id": 96, "seek": 251451, "start": 2491.41, "end": 2514.51, "text": "هذا مهم كتير لأنه بسهل حل و فهم المسائل بشكل أعمق نشوف مثال هذا المثال هكون مثال حسابي", "tokens": [3224, 15730, 3714, 16095, 9122, 2655, 13546, 5296, 33456, 3224, 4724, 3794, 3224, 1211, 11331, 1211, 4032, 6156, 16095, 9673, 3794, 16373, 1211, 4724, 8592, 28820, 5551, 25957, 4587, 8717, 8592, 38688, 50113, 6027, 23758, 9673, 12984, 6027, 8032, 30544, 50113, 6027, 11331, 3794, 16758, 1829], "avg_logprob": -0.12765957319990118, "compression_ratio": 1.4485981308411215, "no_speech_prob": 0.0, "words": [{"start": 2491.41, "end": 2491.69, "word": "هذا", "probability": 0.95947265625}, {"start": 2491.69, "end": 2491.83, "word": " مهم", "probability": 0.985595703125}, {"start": 2491.83, "end": 2492.27, "word": " كتير", "probability": 0.89697265625}, {"start": 2492.27, "end": 2492.77, "word": " لأنه", "probability": 0.8297526041666666}, {"start": 2492.77, "end": 2493.61, "word": " بسهل", "probability": 0.8765869140625}, {"start": 2493.61, "end": 2494.03, "word": " حل", "probability": 0.944091796875}, {"start": 2494.03, "end": 2494.27, "word": " و", "probability": 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254377, "start": 2515.07, "end": 2543.77, "text": "نعتبره تدريب على استخدام او يعني زي calculation exercise a hot rolled steel has a yield strength of S Y T بساوي S Y C بساوي one hundred kilo pound per square inch يعني hot rolled steel yield strength S Y T yield strength in tension بساوي yield strength in compression بساوي مية kilo pound", "tokens": [1863, 34268, 26890, 3224, 6055, 3215, 16572, 3555, 15844, 44713, 9778, 3215, 10943, 1975, 2407, 37495, 22653, 30767, 1829, 17108, 5380, 257, 2368, 14306, 8269, 575, 257, 11257, 3800, 295, 318, 398, 314, 4724, 3794, 995, 45865, 318, 398, 383, 4724, 3794, 995, 45865, 472, 3262, 21112, 12013, 680, 3732, 7227, 37495, 22653, 2368, 14306, 8269, 11257, 3800, 318, 398, 314, 11257, 3800, 294, 8980, 4724, 3794, 995, 45865, 11257, 3800, 294, 19355, 4724, 3794, 995, 45865, 3714, 10632, 21112, 12013], "avg_logprob": -0.20617377903403306, "compression_ratio": 1.728643216080402, "no_speech_prob": 0.0, "words": [{"start": 2515.07, "end": 2515.85, "word": 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steel", "probability": 0.9560546875}, {"start": 2525.99, "end": 2526.39, "word": " has", "probability": 0.93408203125}, {"start": 2526.39, "end": 2526.59, "word": " a", "probability": 0.65234375}, {"start": 2526.59, "end": 2526.71, "word": " yield", "probability": 0.9765625}, {"start": 2526.71, "end": 2527.19, "word": " strength", "probability": 0.951171875}, {"start": 2527.19, "end": 2527.55, "word": " of", "probability": 0.970703125}, {"start": 2527.55, "end": 2528.01, "word": " S", "probability": 0.28955078125}, {"start": 2528.01, "end": 2528.35, "word": " Y", "probability": 0.3212890625}, {"start": 2528.35, "end": 2528.71, "word": " T", "probability": 0.84326171875}, {"start": 2528.71, "end": 2529.25, "word": " بساوي", "probability": 0.4814453125}, {"start": 2529.25, "end": 2529.51, "word": " S", "probability": 0.95068359375}, {"start": 2529.51, "end": 2529.73, "word": " Y", "probability": 0.9921875}, {"start": 2529.73, "end": 2530.03, "word": " C", "probability": 0.92529296875}, {"start": 2530.03, "end": 2530.49, "word": " بساوي", "probability": 0.957275390625}, {"start": 2530.49, "end": 2530.63, "word": " one", "probability": 0.82373046875}, {"start": 2530.63, "end": 2530.85, "word": " hundred", "probability": 0.93359375}, {"start": 2530.85, "end": 2531.15, "word": " kilo", "probability": 0.6767578125}, {"start": 2531.15, "end": 2531.55, "word": " pound", "probability": 0.85205078125}, {"start": 2531.55, "end": 2531.91, "word": " per", "probability": 0.94677734375}, {"start": 2531.91, "end": 2532.11, "word": " square", "probability": 0.89599609375}, {"start": 2532.11, "end": 2532.41, "word": " inch", "probability": 0.96923828125}, {"start": 2532.41, "end": 2533.23, "word": " يعني", "probability": 0.78076171875}, {"start": 2533.23, "end": 2534.07, "word": " hot", "probability": 0.6875}, {"start": 2534.07, "end": 2534.31, "word": " rolled", "probability": 0.9248046875}, {"start": 2534.31, "end": 2534.81, "word": " steel", "probability": 0.9404296875}, {"start": 2534.81, "end": 2535.07, "word": " yield", "probability": 0.2120361328125}, {"start": 2535.07, "end": 2535.49, "word": " strength", "probability": 0.9404296875}, {"start": 2535.49, "end": 2535.79, "word": " S", "probability": 0.794921875}, {"start": 2535.79, "end": 2536.09, "word": " Y", "probability": 0.9580078125}, {"start": 2536.09, "end": 2536.45, "word": " T", "probability": 0.98193359375}, {"start": 2536.45, "end": 2537.99, "word": " yield", "probability": 0.87158203125}, {"start": 2537.99, "end": 2538.33, "word": " strength", "probability": 0.92529296875}, {"start": 2538.33, "end": 2538.53, "word": " in", "probability": 0.921875}, {"start": 2538.53, "end": 2539.51, "word": " tension", "probability": 0.80908203125}, {"start": 2539.51, "end": 2539.99, "word": " بساوي", "probability": 0.9444580078125}, {"start": 2539.99, "end": 2540.23, "word": " yield", "probability": 0.9384765625}, {"start": 2540.23, "end": 2540.61, "word": " strength", "probability": 0.8994140625}, {"start": 2540.61, "end": 2540.83, "word": " in", "probability": 0.93701171875}, {"start": 2540.83, "end": 2541.33, "word": " compression", "probability": 0.92578125}, {"start": 2541.33, "end": 2542.07, "word": " بساوي", "probability": 0.9599609375}, {"start": 2542.07, "end": 2542.97, "word": " مية", "probability": 0.451171875}, {"start": 2542.97, "end": 2543.27, "word": " kilo", "probability": 0.904296875}, {"start": 2543.27, "end": 2543.77, "word": " pound", "probability": 0.978515625}], "temperature": 1.0}, {"id": 98, "seek": 257078, "start": 2544.5, "end": 2570.78, "text": "per square inch و هسميه as well لأنهم متساويين and a true strain at a fracture epsilon f بالساعة point خمسة خمسة هذا أكبر من ايش point او خمسة معناته المادة الشمالها duck tile duck tile material", "tokens": [610, 3732, 7227, 4032, 8032, 38251, 1829, 3224, 382, 731, 5296, 33456, 16095, 44650, 3794, 995, 45865, 9957, 293, 257, 2074, 14249, 412, 257, 36877, 17889, 283, 20666, 3794, 995, 27884, 935, 16490, 2304, 3794, 3660, 16490, 2304, 3794, 3660, 23758, 5551, 4117, 26890, 9154, 1975, 1829, 8592, 935, 1975, 2407, 16490, 2304, 3794, 3660, 20449, 8315, 47395, 9673, 18513, 3660, 25124, 2304, 6027, 11296, 12482, 20590, 12482, 20590, 2527], "avg_logprob": -0.38930458502030707, "compression_ratio": 1.4148936170212767, "no_speech_prob": 0.0, "words": [{"start": 2544.5, "end": 2544.74, "word": "per", "probability": 0.058990478515625}, {"start": 2544.74, "end": 2544.98, "word": " square", "probability": 0.8740234375}, {"start": 2544.98, "end": 2545.26, "word": " inch", "probability": 0.970703125}, {"start": 2545.26, "end": 2545.38, "word": " و", "probability": 0.357666015625}, {"start": 2545.38, "end": 2545.86, "word": " هسميه", "probability": 0.685546875}, {"start": 2545.86, "end": 2546.0, "word": " as", "probability": 0.55859375}, {"start": 2546.0, "end": 2546.26, "word": " well", "probability": 0.2255859375}, {"start": 2546.26, "end": 2546.5, "word": " لأنهم", "probability": 0.6277669270833334}, {"start": 2546.5, "end": 2547.28, "word": " متساويين", "probability": 0.818896484375}, {"start": 2547.28, "end": 2549.78, "word": " and", "probability": 0.74755859375}, {"start": 2549.78, "end": 2550.04, "word": " a", "probability": 0.85595703125}, {"start": 2550.04, "end": 2550.42, "word": " true", "probability": 0.9833984375}, {"start": 2550.42, "end": 2551.26, "word": " strain", "probability": 0.7783203125}, {"start": 2551.26, "end": 2551.78, "word": " at", "probability": 0.9541015625}, {"start": 2551.78, "end": 2551.92, "word": " a", "probability": 0.50048828125}, {"start": 2551.92, "end": 2552.32, "word": " fracture", "probability": 0.931640625}, {"start": 2552.32, "end": 2552.72, "word": " epsilon", "probability": 0.62890625}, {"start": 2552.72, "end": 2553.22, "word": " f", "probability": 0.380859375}, {"start": 2553.22, "end": 2556.5, "word": " بالساعة", "probability": 0.6400146484375}, {"start": 2556.5, "end": 2556.82, "word": " point", "probability": 0.8955078125}, {"start": 2556.82, "end": 2557.5, "word": " خمسة", "probability": 0.923095703125}, {"start": 2557.5, "end": 2558.4, "word": " خمسة", "probability": 0.95654296875}, {"start": 2558.4, "end": 2558.94, "word": " هذا", "probability": 0.324462890625}, {"start": 2558.94, "end": 2559.34, "word": " أكبر", "probability": 0.8870442708333334}, {"start": 2559.34, "end": 2559.62, "word": " من", "probability": 0.98876953125}, {"start": 2559.62, "end": 2560.08, "word": " ايش", "probability": 0.5624186197916666}, {"start": 2560.08, "end": 2563.12, "word": " point", "probability": 0.8408203125}, {"start": 2563.12, "end": 2563.4, "word": " او", "probability": 0.6187744140625}, {"start": 2563.4, "end": 2564.14, "word": " خمسة", "probability": 0.9871826171875}, {"start": 2564.14, "end": 2564.64, "word": " معناته", "probability": 0.8238932291666666}, {"start": 2564.64, "end": 2564.94, "word": " المادة", "probability": 0.6512044270833334}, {"start": 2564.94, "end": 2565.8, "word": " الشمالها", "probability": 0.74249267578125}, {"start": 2565.8, "end": 2566.92, "word": " duck", "probability": 0.22021484375}, {"start": 2566.92, "end": 2567.4, "word": " tile", "probability": 0.546875}, {"start": 2567.4, "end": 2570.2, "word": " duck", "probability": 0.96240234375}, {"start": 2570.2, "end": 2570.44, "word": " tile", "probability": 0.896484375}, {"start": 2570.44, "end": 2570.78, "word": " material", "probability": 0.720703125}], "temperature": 1.0}, {"id": 99, "seek": 260059, "start": 2573.17, "end": 2600.59, "text": "estimate the factor of safety for the following principal stress states احسب ال factor of safety للحالات التالية a sigma x بالساوية سبعين kilo pound per square inch و sigma y بالساوية سبعين kilo pound per square inch", "tokens": [377, 2905, 264, 5952, 295, 4514, 337, 264, 3480, 9716, 4244, 4368, 1975, 5016, 35457, 2423, 5952, 295, 4514, 24976, 5016, 6027, 9307, 16712, 6027, 10632, 257, 12771, 2031, 20666, 3794, 995, 2407, 10632, 8608, 3555, 3615, 9957, 21112, 12013, 680, 3732, 7227, 4032, 12771, 288, 20666, 3794, 995, 2407, 10632, 8608, 3555, 3615, 9957, 21112, 12013, 680, 3732, 7227], "avg_logprob": -0.1404969223210069, "compression_ratio": 1.696774193548387, "no_speech_prob": 0.0, "words": [{"start": 2573.17, "end": 2573.79, "word": "estimate", "probability": 0.60577392578125}, {"start": 2573.79, "end": 2574.05, "word": " the", "probability": 0.90478515625}, {"start": 2574.05, "end": 2574.39, "word": " factor", "probability": 0.88818359375}, {"start": 2574.39, "end": 2574.57, "word": " of", "probability": 0.970703125}, {"start": 2574.57, "end": 2574.97, "word": " safety", "probability": 0.96826171875}, {"start": 2574.97, "end": 2575.37, "word": " for", "probability": 0.91796875}, {"start": 2575.37, "end": 2575.55, "word": " the", "probability": 0.92578125}, {"start": 2575.55, "end": 2575.85, "word": " following", "probability": 0.83984375}, {"start": 2575.85, "end": 2576.25, "word": " principal", "probability": 0.69140625}, {"start": 2576.25, "end": 2576.69, "word": " stress", "probability": 0.9052734375}, {"start": 2576.69, "end": 2577.37, "word": " states", "probability": 0.95361328125}, {"start": 2577.37, "end": 2578.41, "word": " احسب", "probability": 0.912109375}, {"start": 2578.41, "end": 2578.69, "word": " ال", "probability": 0.84033203125}, {"start": 2578.69, "end": 2579.01, "word": " factor", "probability": 0.900390625}, {"start": 2579.01, "end": 2579.21, "word": " of", "probability": 0.96630859375}, {"start": 2579.21, "end": 2579.57, "word": " safety", "probability": 0.970703125}, {"start": 2579.57, "end": 2580.15, "word": " للحالات", "probability": 0.8349609375}, {"start": 2580.15, "end": 2580.49, "word": " التالية", "probability": 0.99609375}, {"start": 2580.49, "end": 2580.81, "word": " a", "probability": 0.462890625}, {"start": 2580.81, "end": 2585.03, "word": " sigma", "probability": 0.39208984375}, {"start": 2585.03, "end": 2585.51, "word": " x", "probability": 0.853515625}, {"start": 2585.51, "end": 2586.57, "word": " بالساوية", "probability": 0.82197265625}, {"start": 2586.57, "end": 2588.17, "word": " سبعين", "probability": 0.927978515625}, {"start": 2588.17, "end": 2589.09, "word": " kilo", "probability": 0.57666015625}, {"start": 2589.09, "end": 2589.49, "word": " pound", "probability": 0.92822265625}, {"start": 2589.49, "end": 2589.85, "word": " per", "probability": 0.9423828125}, {"start": 2589.85, "end": 2590.23, "word": " square", "probability": 0.86376953125}, {"start": 2590.23, "end": 2590.69, "word": " inch", "probability": 0.97509765625}, {"start": 2590.69, "end": 2591.91, "word": " و", "probability": 0.7958984375}, {"start": 2591.91, "end": 2592.29, "word": " sigma", "probability": 0.82470703125}, {"start": 2592.29, "end": 2593.59, "word": " y", "probability": 0.943359375}, {"start": 2593.59, "end": 2596.03, "word": " بالساوية", "probability": 0.982421875}, {"start": 2596.03, "end": 2597.81, "word": " سبعين", "probability": 0.9896240234375}, {"start": 2597.81, "end": 2599.23, "word": " kilo", "probability": 0.96484375}, {"start": 2599.23, "end": 2599.61, "word": " pound", "probability": 0.98193359375}, {"start": 2599.61, "end": 2599.89, "word": " per", "probability": 0.97021484375}, {"start": 2599.89, "end": 2600.23, "word": " square", "probability": 0.88916015625}, {"start": 2600.23, "end": 2600.59, "word": " inch", "probability": 0.974609375}], "temperature": 1.0}, {"id": 100, "seek": 262693, "start": 2601.79, "end": 2626.93, "text": "و τاو اكس واي بالثاوزيرو اوتوماتيك لما نطلع حالة الشير stress بالثاوز سفر معناته هدول بيمثل ايش؟ principal stresses عند ال principal planes بيكونش فيه شير ففي الشي ده يعمل calculation على طول سيجما واحد في الحالة دي سيجما واحد because لأنه", "tokens": [2407, 3596, 995, 2407, 1975, 4117, 3794, 36764, 1829, 20666, 12984, 995, 2407, 11622, 13546, 2407, 1975, 35473, 20498, 9307, 1829, 4117, 5296, 15042, 8717, 9566, 1211, 3615, 11331, 6027, 3660, 25124, 13546, 4244, 20666, 12984, 995, 2407, 11622, 8608, 5172, 2288, 20449, 8315, 47395, 8032, 3215, 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0.7357991536458334}, {"start": 2606.27, "end": 2606.43, "word": " لما", "probability": 0.8671875}, {"start": 2606.43, "end": 2606.83, "word": " نطلع", "probability": 0.9212646484375}, {"start": 2606.83, "end": 2607.43, "word": " حالة", "probability": 0.8421223958333334}, {"start": 2607.43, "end": 2608.57, "word": " الشير", "probability": 0.816650390625}, {"start": 2608.57, "end": 2609.07, "word": " stress", "probability": 0.21630859375}, {"start": 2609.07, "end": 2609.85, "word": " بالثاوز", "probability": 0.7990234375}, {"start": 2609.85, "end": 2610.29, "word": " سفر", "probability": 0.9129231770833334}, {"start": 2610.29, "end": 2612.81, "word": " معناته", "probability": 0.884765625}, {"start": 2612.81, "end": 2613.07, "word": " هدول", "probability": 0.923828125}, {"start": 2613.07, "end": 2613.63, "word": " بيمثل", "probability": 0.8880615234375}, {"start": 2613.63, "end": 2614.99, "word": " ايش؟", "probability": 0.63201904296875}, {"start": 2614.99, "end": 2615.35, "word": " principal", "probability": 0.332275390625}, {"start": 2615.35, "end": 2615.85, "word": " stresses", "probability": 0.89453125}, {"start": 2615.85, "end": 2616.51, "word": " عند", "probability": 0.93994140625}, {"start": 2616.51, "end": 2616.67, "word": " ال", "probability": 0.87744140625}, {"start": 2616.67, "end": 2616.99, "word": " principal", "probability": 0.6591796875}, {"start": 2616.99, "end": 2617.59, "word": " planes", "probability": 0.939453125}, {"start": 2617.59, "end": 2618.49, "word": " بيكونش", "probability": 0.8673095703125}, {"start": 2618.49, "end": 2618.73, "word": " فيه", "probability": 0.8671875}, {"start": 2618.73, "end": 2619.03, "word": " شير", "probability": 0.911376953125}, {"start": 2619.03, "end": 2619.87, "word": " ففي", "probability": 0.7919921875}, {"start": 2619.87, "end": 2619.95, "word": " الشي", "probability": 0.5433349609375}, {"start": 2619.95, "end": 2620.07, "word": " ده", "probability": 0.8271484375}, {"start": 2620.07, "end": 2620.21, "word": " 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sigma", "probability": 0.8291015625}, {"start": 3019.73, "end": 3019.97, "word": " prime", "probability": 0.599609375}, {"start": 3019.97, "end": 3020.33, "word": " بيستوى", "probability": 0.637548828125}, {"start": 3020.33, "end": 3020.67, "word": " Sy", "probability": 0.18310546875}, {"start": 3020.67, "end": 3021.19, "word": " على", "probability": 0.625}, {"start": 3021.19, "end": 3022.03, "word": " N", "probability": 0.81591796875}, {"start": 3022.03, "end": 3032.21, "word": " اه", "probability": 0.745849609375}], "temperature": 1.0}, {"id": 116, "seek": 306312, "start": 3034.58, "end": 3063.12, "text": "ف ال sigma prime بيستوى SY على N و ال N بيستوى SY على sigma prime و منها بحسب اللي هو SY عند 100 و ال sigma prime تطلع 70 100 على 70 المفروض تطلع حسبوليها 100 قصيم 70 تطلع 1.43 طيب خنشوف مثال تاني انحله", "tokens": [5172, 2423, 12771, 5835, 4724, 1829, 14851, 2407, 7578, 32624, 15844, 426, 4032, 2423, 426, 4724, 1829, 14851, 2407, 7578, 32624, 15844, 12771, 5835, 4032, 9154, 11296, 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{"start": 3040.92, "end": 3041.38, "word": " بحسب", "probability": 0.9484049479166666}, {"start": 3041.38, "end": 3041.86, "word": " اللي", "probability": 0.69482421875}, {"start": 3041.86, "end": 3042.14, "word": " هو", "probability": 0.97900390625}, {"start": 3042.14, "end": 3042.56, "word": " SY", "probability": 0.8056640625}, {"start": 3042.56, "end": 3042.84, "word": " عند", "probability": 0.9052734375}, {"start": 3042.84, "end": 3043.62, "word": " 100", "probability": 0.388916015625}, {"start": 3043.62, "end": 3044.44, "word": " و", "probability": 0.86767578125}, {"start": 3044.44, "end": 3044.6, "word": " ال", "probability": 0.53662109375}, {"start": 3044.6, "end": 3044.94, "word": " sigma", "probability": 0.80908203125}, {"start": 3044.94, "end": 3045.28, "word": " prime", "probability": 0.880859375}, {"start": 3045.28, "end": 3045.76, "word": " تطلع", "probability": 0.9022216796875}, {"start": 3045.76, "end": 3046.36, "word": " 70", "probability": 0.80078125}, {"start": 3046.36, "end": 3046.66, "word": " 100", "probability": 0.53369140625}, {"start": 3046.66, "end": 3046.84, "word": " على", "probability": 0.65478515625}, {"start": 3046.84, "end": 3047.34, "word": " 70", "probability": 0.95947265625}, {"start": 3047.34, "end": 3048.38, "word": " المفروض", "probability": 0.9688720703125}, {"start": 3048.38, "end": 3048.7, "word": " تطلع", "probability": 0.986328125}, {"start": 3048.7, "end": 3049.42, "word": " حسبوليها", "probability": 0.683203125}, {"start": 3049.42, "end": 3049.92, "word": " 100", "probability": 0.65869140625}, {"start": 3049.92, "end": 3052.44, "word": " قصيم", "probability": 0.5018717447916666}, {"start": 3052.44, "end": 3053.06, "word": " 70", "probability": 0.79443359375}, {"start": 3053.06, "end": 3054.9, "word": " تطلع", "probability": 0.9658203125}, {"start": 3054.9, "end": 3055.08, "word": " 1", "probability": 0.7060546875}, {"start": 3055.08, "end": 3056.46, "word": ".43", "probability": 0.98193359375}, {"start": 3056.46, 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{"id": 118, "seek": 312449, "start": 3096.73, "end": 3124.49, "text": "if state of stress is in the fourth quadrant هذا تصحيح لأن صار عندي خربش انا fourth quadrant معناته sigma a أكبر أو يساوي الصفر أكبر أو يساوي ال sigma b يعني واحد موجة و واحد سالب في الحالة هذه in this case", "tokens": [351, 1785, 295, 4244, 307, 294, 264, 6409, 46856, 23758, 6055, 9381, 5016, 1829, 5016, 5296, 33456, 20328, 9640, 18871, 16254, 16490, 2288, 3555, 8592, 1975, 8315, 6409, 46856, 20449, 8315, 47395, 12771, 257, 5551, 4117, 26890, 34051, 7251, 3794, 995, 45865, 31767, 5172, 2288, 5551, 4117, 26890, 34051, 7251, 3794, 995, 45865, 2423, 12771, 272, 37495, 22653, 36764, 24401, 3714, 29245, 3660, 4032, 36764, 24401, 8608, 6027, 3555, 8978, 21542, 6027, 3660, 29538, 294, 341, 1389], "avg_logprob": -0.24038461309212905, "compression_ratio": 1.6021505376344085, "no_speech_prob": 1.7881393432617188e-07, "words": [{"start": 3096.7299999999996, "end": 3097.6099999999997, "word": "if", "probability": 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{"start": 3125.6, "end": 3125.8, "word": " أن", "probability": 0.428955078125}, {"start": 3125.8, "end": 3126.64, "word": " الـ", "probability": 0.507568359375}, {"start": 3126.64, "end": 3126.92, "word": " N", "probability": 0.7021484375}, {"start": 3126.92, "end": 3128.22, "word": " بستواء", "probability": 0.5604248046875}, {"start": 3128.22, "end": 3130.32, "word": " SSY", "probability": 0.88671875}, {"start": 3130.32, "end": 3131.32, "word": " على", "probability": 0.5263671875}, {"start": 3131.32, "end": 3132.1, "word": " TAU", "probability": 0.5098876953125}, {"start": 3132.1, "end": 3132.6, "word": " maximum", "probability": 0.6943359375}, {"start": 3132.6, "end": 3133.42, "word": " هذا", "probability": 0.6376953125}, {"start": 3133.42, "end": 3133.6, "word": " في", "probability": 0.9501953125}, {"start": 3133.6, "end": 3134.14, "word": " حالة", "probability": 0.9912109375}], "temperature": 1.0}, {"id": 120, "seek": 315644, "start": 3134.72, "end": 3156.44, "text": "الـ distortion energy theory وفي حالة ال maximum shear stress theory لكن في حالة ال distortion energy theory بتكون عند ال S S Y بيسوابون خمسة سبعة سبعة S Y و ال S S Y في حالة ال maximum shear stress theory بتكون سوابون مصر S Y", "tokens": [6027, 39184, 28426, 2281, 5261, 4032, 41185, 11331, 6027, 3660, 2423, 6674, 24082, 4244, 5261, 44381, 8978, 11331, 6027, 3660, 2423, 28426, 2281, 5261, 39894, 30544, 43242, 2423, 318, 318, 398, 4724, 1829, 3794, 14407, 3555, 11536, 16490, 2304, 3794, 3660, 8608, 3555, 27884, 8608, 3555, 27884, 318, 398, 4032, 2423, 318, 318, 398, 8978, 11331, 6027, 3660, 2423, 6674, 24082, 4244, 5261, 39894, 30544, 8608, 14407, 3555, 11536, 3714, 9381, 2288, 318, 398], "avg_logprob": -0.25104165395100914, "compression_ratio": 1.9363057324840764, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 3134.72, "end": 3135.06, "word": "الـ", "probability": 0.63720703125}, {"start": 3135.06, "end": 3135.54, "word": " distortion", "probability": 0.65625}, {"start": 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"end": 3147.88, "word": " سبعة", "probability": 0.7683919270833334}, {"start": 3147.88, "end": 3148.5, "word": " سبعة", "probability": 0.8473307291666666}, {"start": 3148.5, "end": 3148.88, "word": " S", "probability": 0.81591796875}, {"start": 3148.88, "end": 3149.28, "word": " Y", "probability": 0.9189453125}, {"start": 3149.28, "end": 3149.98, "word": " و", "probability": 0.75537109375}, {"start": 3149.98, "end": 3150.14, "word": " ال", "probability": 0.378662109375}, {"start": 3150.14, "end": 3150.46, "word": " S", "probability": 0.98046875}, {"start": 3150.46, "end": 3150.76, "word": " S", "probability": 0.96630859375}, {"start": 3150.76, "end": 3151.02, "word": " Y", "probability": 0.9775390625}, {"start": 3151.02, "end": 3151.3, "word": " في", "probability": 0.92578125}, {"start": 3151.3, "end": 3152.4, "word": " حالة", "probability": 0.99755859375}, {"start": 3152.4, "end": 3152.64, "word": " ال", "probability": 0.88134765625}, {"start": 3152.64, "end": 3153.2, "word": " maximum", "probability": 0.98486328125}, {"start": 3153.2, "end": 3153.62, "word": " shear", "probability": 0.95458984375}, {"start": 3153.62, "end": 3153.98, "word": " stress", "probability": 0.875}, {"start": 3153.98, "end": 3154.46, "word": " theory", "probability": 0.72705078125}, {"start": 3154.46, "end": 3155.14, "word": " بتكون", "probability": 0.91455078125}, {"start": 3155.14, "end": 3155.46, "word": " سوابون", "probability": 0.7789306640625}, {"start": 3155.46, "end": 3155.86, "word": " مصر", "probability": 0.6363932291666666}, {"start": 3155.86, "end": 3156.16, "word": " S", "probability": 0.8740234375}, {"start": 3156.16, "end": 3156.44, "word": " Y", "probability": 0.9580078125}], "temperature": 1.0}, {"id": 121, "seek": 318633, "start": 3158.15, "end": 3186.33, "text": "معناته الحل السابق ينطبق في ال fourth quadrant لكن انا وين طلعت عندي sigma a موجبة و sigma b موجبة انا في ال first quadrant معناته this is not valid يعني if state of stress is in the first quadrant", 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"word": " more", "probability": 0.94384765625}, {"start": 3302.73, "end": 3304.31, "word": " circle", "probability": 0.92919921875}, {"start": 3304.31, "end": 3305.53, "word": " more", "probability": 0.88818359375}, {"start": 3305.53, "end": 3306.07, "word": " circle", "probability": 0.94873046875}], "temperature": 1.0}, {"id": 126, "seek": 333954, "start": 3313.76, "end": 3339.54, "text": "أنا هستخدم عندي هنا هنا counter clockwise موجة وهنا clockwise سالف معناته هتكون عندي هنا سيج ماكس اللي هي ستين ستين وخمستاشر clockwise هتكون ستين انا عندي عشرة عشرين تلاتين اربعين خمسين ستين هنا عشرة عشرين", "tokens": [10721, 8315, 8032, 14851, 9778, 40448, 18871, 16254, 34105, 34105, 5682, 35790, 3714, 29245, 3660, 37037, 8315, 35790, 8608, 6027, 5172, 20449, 8315, 47395, 8032, 2655, 30544, 18871, 16254, 34105, 8608, 1829, 7435, 19446, 4117, 3794, 13672, 1829, 39896, 8608, 2655, 9957, 8608, 2655, 9957, 4032, 9778, 2304, 14851, 33599, 2288, 35790, 8032, 2655, 30544, 8608, 2655, 9957, 1975, 8315, 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3327.78, "end": 3328.82, "word": " ستين", "probability": 0.8670247395833334}, {"start": 3328.82, "end": 3329.44, "word": " وخمستاشر", "probability": 0.7218424479166666}, {"start": 3329.44, "end": 3329.72, "word": " clockwise", "probability": 0.91748046875}, {"start": 3329.72, "end": 3330.14, "word": " هتكون", "probability": 0.8917643229166666}, {"start": 3330.14, "end": 3330.62, "word": " ستين", "probability": 0.9259440104166666}, {"start": 3330.62, "end": 3330.76, "word": " انا", "probability": 0.45831298828125}, {"start": 3330.76, "end": 3330.96, "word": " عندي", "probability": 0.921875}, {"start": 3330.96, "end": 3331.52, "word": " عشرة", "probability": 0.845703125}, {"start": 3331.52, "end": 3333.08, "word": " عشرين", "probability": 0.9513346354166666}, {"start": 3333.08, "end": 3334.66, "word": " تلاتين", "probability": 0.940673828125}, {"start": 3334.66, "end": 3335.46, "word": " اربعين", "probability": 0.9395751953125}, {"start": 3335.46, "end": 3336.16, "word": " خمسين", "probability": 0.9898681640625}, {"start": 3336.16, "end": 3336.82, "word": " ستين", "probability": 0.9876302083333334}, {"start": 3336.82, "end": 3337.44, "word": " هنا", "probability": 0.533203125}, {"start": 3337.44, "end": 3338.08, "word": " عشرة", "probability": 0.9345703125}, {"start": 3338.08, "end": 3339.54, "word": " عشرين", "probability": 0.9254557291666666}], "temperature": 1.0}, {"id": 127, "seek": 337131, "start": 3342.29, "end": 3371.31, "text": "هذه عشرة عشرين تلاتين أربعين خمسين ستين هذا أول نقطة اللي هي sigma X اللي هي ستين وخمستاش clockwise سالب النقطة التانية اللي هي أربعين أربعين هذه سالب عشرة سالب عشرين", "tokens": [3224, 24192, 6225, 8592, 25720, 6225, 46309, 9957, 6055, 1211, 9307, 9957, 5551, 25513, 3615, 9957, 16490, 2304, 3794, 9957, 8608, 2655, 9957, 23758, 5551, 12610, 8717, 47432, 3660, 13672, 1829, 39896, 12771, 1783, 13672, 1829, 39896, 8608, 2655, 9957, 4032, 9778, 2304, 14851, 33599, 35790, 8608, 6027, 3555, 28239, 47432, 3660, 16712, 7649, 10632, 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"probability": 0.864013671875}, {"start": 3351.19, "end": 3351.57, "word": " نقطة", "probability": 0.9814453125}, {"start": 3351.57, "end": 3351.71, "word": " اللي", "probability": 0.49951171875}, {"start": 3351.71, "end": 3351.81, "word": " هي", "probability": 0.927734375}, {"start": 3351.81, "end": 3352.11, "word": " sigma", "probability": 0.345458984375}, {"start": 3352.11, "end": 3352.57, "word": " X", "probability": 0.66748046875}, {"start": 3352.57, "end": 3354.15, "word": " اللي", "probability": 0.760986328125}, {"start": 3354.15, "end": 3354.27, "word": " هي", "probability": 0.83740234375}, {"start": 3354.27, "end": 3354.85, "word": " ستين", "probability": 0.9781901041666666}, {"start": 3354.85, "end": 3357.85, "word": " وخمستاش", "probability": 0.83095703125}, {"start": 3357.85, "end": 3358.67, "word": " clockwise", "probability": 0.5966796875}, {"start": 3358.67, "end": 3360.99, "word": " سالب", "probability": 0.7643229166666666}, {"start": 3360.99, "end": 3362.23, "word": " النقطة", "probability": 0.9720052083333334}, {"start": 3362.23, "end": 3362.59, "word": " التانية", "probability": 0.97802734375}, {"start": 3362.59, "end": 3362.85, "word": " اللي", "probability": 0.98291015625}, {"start": 3362.85, "end": 3363.01, "word": " هي", "probability": 0.90576171875}, {"start": 3363.01, "end": 3363.73, "word": " أربعين", "probability": 0.8985595703125}, {"start": 3363.73, "end": 3365.79, "word": " أربعين", "probability": 0.938232421875}, {"start": 3365.79, "end": 3368.09, "word": " هذه", "probability": 0.480224609375}, {"start": 3368.09, "end": 3368.69, "word": " سالب", "probability": 0.9280598958333334}, {"start": 3368.69, "end": 3369.13, "word": " عشرة", "probability": 0.92041015625}, {"start": 3369.13, "end": 3370.69, "word": " سالب", "probability": 0.9733072916666666}, {"start": 3370.69, "end": 3371.31, "word": " عشرين", "probability": 0.9449869791666666}], "temperature": 1.0}, {"id": 128, "seek": 340612, "start": 3378.32, "end": 3406.12, "text": "هذه ستكون اربعين وخمستاش counter clockwise هوصل بينهم و ارسم more circle هذه more circle معناته هذه ستكون sigma واحد", "tokens": [3224, 24192, 8608, 2655, 30544, 1975, 25513, 3615, 9957, 4032, 9778, 2304, 14851, 33599, 5682, 35790, 8032, 2407, 36520, 49374, 16095, 4032, 1975, 2288, 38251, 544, 6329, 29538, 544, 6329, 20449, 8315, 47395, 29538, 8608, 2655, 30544, 12771, 36764, 24401], "avg_logprob": -0.28258384727850194, "compression_ratio": 1.3543307086614174, "no_speech_prob": 0.0, "words": [{"start": 3378.32, "end": 3378.6, "word": "هذه", "probability": 0.6177978515625}, {"start": 3378.6, "end": 3378.92, "word": " ستكون", "probability": 0.8427734375}, {"start": 3378.92, "end": 3379.54, "word": " اربعين", "probability": 0.835693359375}, {"start": 3379.54, "end": 3382.42, "word": " وخمستاش", "probability": 0.73349609375}, {"start": 3382.42, "end": 3382.86, "word": " counter", "probability": 0.50390625}, {"start": 3382.86, "end": 3383.48, "word": " clockwise", "probability": 0.73193359375}, {"start": 3383.48, "end": 3385.84, "word": " هوصل", "probability": 0.8175455729166666}, {"start": 3385.84, "end": 3386.7, "word": " بينهم", "probability": 0.9775390625}, {"start": 3386.7, "end": 3389.96, "word": " و", "probability": 0.83154296875}, {"start": 3389.96, "end": 3390.42, "word": " ارسم", "probability": 0.8065592447916666}, {"start": 3390.42, "end": 3390.78, "word": " more", "probability": 0.7265625}, {"start": 3390.78, "end": 3391.38, "word": " circle", "probability": 0.9482421875}, {"start": 3391.38, "end": 3400.02, "word": " هذه", "probability": 0.720703125}, {"start": 3400.02, "end": 3400.3, "word": " more", "probability": 0.85107421875}, {"start": 3400.3, "end": 3400.82, "word": " circle", "probability": 0.94384765625}, {"start": 3400.82, "end": 3402.56, "word": " معناته", "probability": 0.7530924479166666}, {"start": 3402.56, "end": 3402.7, "word": " هذه", "probability": 0.3544921875}, {"start": 3402.7, "end": 3403.18, "word": " ستكون", "probability": 0.9375}, {"start": 3403.18, "end": 3405.54, "word": " sigma", "probability": 0.280029296875}, {"start": 3405.54, "end": 3406.12, "word": " واحد", "probability": 0.94287109375}], "temperature": 1.0}, {"id": 129, "seek": 343189, "start": 3407.13, "end": 3431.89, "text": "و هاد ال sigma 2 و هاد ال sigma 3 طيب هذا هو ال center هذا ال center تعمار circle ال C بسوة sigma X زي sigma Y على 2 اللي هي 60 زي 40", "tokens": [2407, 8032, 18513, 2423, 12771, 568, 4032, 8032, 18513, 2423, 12771, 805, 23032, 1829, 3555, 23758, 31439, 2423, 3056, 23758, 2423, 3056, 37279, 2304, 9640, 6329, 2423, 383, 4724, 3794, 2407, 3660, 12771, 1783, 30767, 1829, 12771, 398, 15844, 568, 13672, 1829, 39896, 4060, 30767, 1829, 3356], "avg_logprob": -0.3011067695915699, "compression_ratio": 1.4375, "no_speech_prob": 0.0, "words": [{"start": 3407.13, "end": 3407.31, "word": "و", "probability": 0.853515625}, {"start": 3407.31, "end": 3407.55, "word": " هاد", "probability": 0.29315185546875}, {"start": 3407.55, "end": 3407.69, 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"probability": 0.77978515625}, {"start": 3415.83, "end": 3416.77, "word": " هذا", "probability": 0.6044921875}, {"start": 3416.77, "end": 3417.17, "word": " ال", "probability": 0.9619140625}, {"start": 3417.17, "end": 3417.59, "word": " center", "probability": 0.9052734375}, {"start": 3417.59, "end": 3418.63, "word": " تعمار", "probability": 0.7171223958333334}, {"start": 3418.63, "end": 3419.15, "word": " circle", "probability": 0.75146484375}, {"start": 3419.15, "end": 3421.91, "word": " ال", "probability": 0.87451171875}, {"start": 3421.91, "end": 3422.29, "word": " C", "probability": 0.65771484375}, {"start": 3422.29, "end": 3425.31, "word": " بسوة", "probability": 0.56890869140625}, {"start": 3425.31, "end": 3425.67, "word": " sigma", "probability": 0.861328125}, {"start": 3425.67, "end": 3426.21, "word": " X", "probability": 0.8271484375}, {"start": 3426.21, "end": 3426.83, "word": " زي", "probability": 0.5965576171875}, {"start": 3426.83, "end": 3427.27, "word": " sigma", "probability": 0.72314453125}, {"start": 3427.27, "end": 3427.71, "word": " Y", "probability": 0.97314453125}, {"start": 3427.71, "end": 3428.89, "word": " على", "probability": 0.7041015625}, {"start": 3428.89, "end": 3429.23, "word": " 2", "probability": 0.974609375}, {"start": 3429.23, "end": 3429.49, "word": " اللي", "probability": 0.88037109375}, {"start": 3429.49, "end": 3429.79, "word": " هي", "probability": 0.81689453125}, {"start": 3429.79, "end": 3430.87, "word": " 60", "probability": 0.720703125}, {"start": 3430.87, "end": 3431.35, "word": " زي", "probability": 0.78515625}, {"start": 3431.35, "end": 3431.89, "word": " 40", "probability": 0.955078125}], "temperature": 1.0}, {"id": 130, "seek": 345619, "start": 3433.01, "end": 3456.19, "text": "على اتنين اللي هو خمسين kilo pound per square inch هذه المسافة هذه sigma x او tau xy", "tokens": [3615, 23942, 1975, 2655, 1863, 9957, 13672, 1829, 31439, 16490, 2304, 3794, 9957, 21112, 12013, 680, 3732, 7227, 29538, 9673, 3794, 31845, 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سيجما واحد بيساوي سيجما اتنين بيساوي سيجما تلاتة ما انا حابب اتمثل هذه hydrostatic هذه hydrostatic state of stress", "tokens": [2407, 8608, 1829, 7435, 15042, 6055, 1211, 9307, 3660, 29538, 20193, 5016, 19913, 14407, 8608, 1829, 7435, 15042, 36764, 24401, 4724, 1829, 3794, 995, 45865, 8608, 1829, 7435, 15042, 1975, 2655, 1863, 9957, 4724, 1829, 3794, 995, 45865, 8608, 1829, 7435, 15042, 6055, 1211, 9307, 3660, 19446, 1975, 8315, 11331, 16758, 3555, 1975, 39237, 12984, 1211, 29538, 5796, 27494, 2399, 29538, 5796, 27494, 2399, 1785, 295, 4244], "avg_logprob": -0.2325367688694421, "compression_ratio": 1.7322834645669292, "no_speech_prob": 0.0, "words": [{"start": 3918.09, "end": 3918.37, "word": "و", "probability": 0.8701171875}, {"start": 3918.37, "end": 3918.69, "word": " سيجما", "probability": 0.4957275390625}, {"start": 3918.69, "end": 3919.71, "word": " تلاتة", "probability": 0.9234619140625}, {"start": 3919.71, "end": 3928.73, "word": " هذه", "probability": 0.37451171875}, {"start": 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circle", "probability": 0.291015625}, {"start": 4238.26, "end": 4238.92, "word": " R", "probability": 0.54443359375}, {"start": 4238.92, "end": 4240.32, "word": " أستعمر", "probability": 0.652313232421875}, {"start": 4240.32, "end": 4240.58, "word": " جزر", "probability": 0.9093424479166666}, {"start": 4240.58, "end": 4241.16, "word": " التربيه", "probability": 0.749755859375}], "temperature": 1.0}, {"id": 157, "seek": 427188, "start": 4243.04, "end": 4271.88, "text": "لعشرين تربيع زاد خمس و أربعين تربيع عشرين تربيع زاد خمس و أربعين تربيع بيطلع تسعة و أربعين point اتنين اربعة تسعة و أربعين kilo pound per square inch", "tokens": [1211, 3615, 8592, 16572, 1863, 6055, 2288, 21292, 3615, 30767, 18513, 16490, 2304, 3794, 4032, 5551, 25513, 3615, 9957, 6055, 2288, 21292, 3615, 6225, 8592, 16572, 1863, 6055, 2288, 21292, 3615, 30767, 18513, 16490, 2304, 3794, 4032, 5551, 25513, 3615, 9957, 6055, 2288, 21292, 3615, 4724, 1829, 9566, 1211, 3615, 6055, 3794, 27884, 4032, 5551, 25513, 3615, 9957, 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"probability": 0.92041015625}], "temperature": 1.0}, {"id": 44, "seek": 119703, "start": 1169.27, "end": 1197.03, "text": "الان انا ممكن اصنف او اعمل تصنيفات على ال curve بطرق مختلفة ممكن to define low cycle fatigue يعني عندي هنا low cycle fatigue من هنا لهنا وعندي", "tokens": [6027, 7649, 1975, 8315, 3714, 43020, 1975, 9381, 1863, 5172, 1975, 2407, 1975, 25957, 1211, 6055, 9381, 22653, 5172, 9307, 15844, 2423, 7605, 4724, 9566, 2288, 4587, 3714, 46456, 46538, 3660, 3714, 43020, 281, 6964, 2295, 6586, 20574, 37495, 22653, 18871, 16254, 34105, 2295, 6586, 20574, 9154, 34105, 46740, 8315, 4032, 3615, 1863, 16254], "avg_logprob": -0.1555397792295976, "compression_ratio": 1.4657534246575343, "no_speech_prob": 0.0, "words": [{"start": 1169.27, "end": 1169.67, "word": "الان", "probability": 0.73681640625}, {"start": 1169.67, "end": 1169.91, "word": " انا", "probability": 0.884765625}, {"start": 1169.91, "end": 1170.15, "word": " ممكن", "probability": 0.987060546875}, {"start": 1170.15, 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elastic external amplitude زي ال plastic external amplitude لكن انا عندي هاي هذا elastic external amplitude وهي plastic external amplitude", "tokens": [3615, 46309, 5551, 4587, 9381, 8717, 995, 4587, 9381, 38637, 1211, 5718, 104, 3660, 6225, 46309, 5551, 4587, 9381, 8717, 995, 4587, 9381, 1975, 2655, 1863, 9957, 6225, 46309, 5551, 4587, 9381, 8717, 995, 4587, 9381, 36764, 24401, 6225, 46309, 5551, 4587, 9381, 8608, 5172, 2288, 39896, 6225, 46309, 5551, 4587, 9381, 8608, 5172, 2288, 6225, 46309, 5551, 4587, 9381, 36764, 24401, 6225, 46309, 5551, 4587, 9381, 1975, 2655, 1863, 9957, 6225, 46309, 5551, 4587, 9381, 6055, 1211, 9307, 3660, 6225, 46309, 5551, 4587, 9381, 5551, 25513, 27884, 6225, 46309, 5551, 4587, 9381, 16490, 2304, 3794, 3660, 6225, 46309, 5551, 4587, 9381, 8608, 2655, 3660, 5296, 33456, 20193, 5016, 19913, 14407, 8289, 8236, 17115, 15844, 1975, 2655, 1863, 9957, 20666, 3794, 995, 2407, 10632, 2423, 17115, 8320, 27433, 30767, 1829, 2423, 5900, 8320, 27433, 44381, 1975, 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2389.77, "end": 2417.97, "text": "الـ slope هذا ايش يمثل ايه هذا برضه ايه وهي اللي عندي هنا delta epsilon elastic على اتنين وهذه هتكون سيجما", "tokens": [6027, 39184, 13525, 23758, 1975, 1829, 8592, 7251, 2304, 12984, 1211, 1975, 1829, 3224, 23758, 4724, 43042, 3224, 1975, 1829, 3224, 37037, 1829, 13672, 1829, 18871, 16254, 34105, 8289, 17889, 17115, 15844, 1975, 2655, 1863, 9957, 37037, 24192, 8032, 2655, 30544, 8608, 1829, 7435, 15042], "avg_logprob": -0.3189538062914558, "compression_ratio": 1.302325581395349, "no_speech_prob": 0.0, "words": [{"start": 2389.77, "end": 2390.07, "word": "الـ", "probability": 0.601318359375}, {"start": 2390.07, "end": 2390.41, "word": " slope", "probability": 0.83154296875}, {"start": 2390.41, "end": 2390.75, "word": " هذا", "probability": 0.7314453125}, {"start": 2390.75, "end": 2391.11, "word": " ايش", "probability": 0.647705078125}, {"start": 2391.11, "end": 2392.79, "word": " يمثل", "probability": 0.8712158203125}, {"start": 2392.79, "end": 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0.76611328125}], "temperature": 1.0}, {"id": 93, "seek": 260898, "start": 2596.0, "end": 2608.98, "text": "فى اتنين N قصى C و ال Delta Epsilon Elastic على اتنين هتكون اللى هى Sigma F Prime على E فى اتنين N قصى B", "tokens": [5172, 7578, 1975, 2655, 1863, 9957, 426, 12174, 9381, 7578, 383, 4032, 2423, 18183, 462, 16592, 2699, 2750, 15844, 1975, 2655, 1863, 9957, 8032, 2655, 30544, 13672, 7578, 8032, 7578, 36595, 479, 9655, 15844, 462, 6156, 7578, 1975, 2655, 1863, 9957, 426, 12174, 9381, 7578, 363], "avg_logprob": -0.4079122479925764, "compression_ratio": 1.3669724770642202, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 2596.0, "end": 2596.32, "word": "فى", "probability": 0.2742919921875}, {"start": 2596.32, "end": 2596.62, "word": " اتنين", "probability": 0.76995849609375}, {"start": 2596.62, "end": 2597.0, "word": " N", "probability": 0.52001953125}, {"start": 2597.0, "end": 2597.6, "word": " قصى", "probability": 0.4501546223958333}, {"start": 2597.6, "end": 2597.86, "word": " C", "probability": 0.498779296875}, {"start": 2597.86, "end": 2598.68, "word": " و", "probability": 0.505859375}, {"start": 2598.68, "end": 2598.88, "word": " ال", "probability": 0.392578125}, {"start": 2598.88, "end": 2599.44, "word": " Delta", "probability": 0.433837890625}, {"start": 2599.44, "end": 2600.08, "word": " Epsilon", "probability": 0.74853515625}, {"start": 2600.08, "end": 2601.1, "word": " Elastic", "probability": 0.57208251953125}, {"start": 2601.1, "end": 2601.6, "word": " على", "probability": 0.65087890625}, {"start": 2601.6, "end": 2602.22, "word": " اتنين", "probability": 0.97216796875}, {"start": 2602.22, "end": 2603.5, "word": " هتكون", "probability": 0.8933919270833334}, {"start": 2603.5, "end": 2604.1, "word": " اللى", "probability": 0.636474609375}, {"start": 2604.1, "end": 2604.44, "word": " هى", "probability": 0.860595703125}, {"start": 2604.44, "end": 2604.82, "word": " Sigma", "probability": 0.7353515625}, {"start": 2604.82, "end": 2605.22, "word": " F", "probability": 0.9697265625}, {"start": 2605.22, "end": 2605.78, "word": " Prime", "probability": 0.376708984375}, {"start": 2605.78, "end": 2606.2, "word": " على", "probability": 0.7880859375}, {"start": 2606.2, "end": 2606.58, "word": " E", "probability": 0.8759765625}, {"start": 2606.58, "end": 2607.38, "word": " فى", "probability": 0.984130859375}, {"start": 2607.38, "end": 2607.72, "word": " اتنين", "probability": 0.978515625}, {"start": 2607.72, "end": 2608.08, "word": " N", "probability": 0.98876953125}, {"start": 2608.08, "end": 2608.8, "word": " قصى", "probability": 0.8424479166666666}, {"start": 2608.8, "end": 2608.98, "word": " B", "probability": 0.9345703125}], "temperature": 1.0}, {"id": 94, "seek": 264101, "start": 2618.39, "end": 2641.01, "text": "لو أخدت ال log للطرفين هتطلع علاقة إيش linear هتطلع linear بين ال log دلت أبسترون مع ال cycle ال number of reversals طيب", "tokens": [1211, 2407, 5551, 9778, 3215, 2655, 2423, 3565, 24976, 9566, 28480, 9957, 8032, 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"probability": 0.5050455729166666}, {"start": 2621.09, "end": 2621.57, "word": " linear", "probability": 0.34423828125}, {"start": 2621.57, "end": 2621.99, "word": " هتطلع", "probability": 0.8869140625}, {"start": 2621.99, "end": 2622.29, "word": " linear", "probability": 0.53173828125}, {"start": 2622.29, "end": 2622.51, "word": " بين", "probability": 0.943359375}, {"start": 2622.51, "end": 2622.65, "word": " ال", "probability": 0.68212890625}, {"start": 2622.65, "end": 2622.81, "word": " log", "probability": 0.86767578125}, {"start": 2622.81, "end": 2623.11, "word": " دلت", "probability": 0.6705525716145834}, {"start": 2623.11, "end": 2623.33, "word": " أبسترون", "probability": 0.761279296875}, {"start": 2623.33, "end": 2625.05, "word": " مع", "probability": 0.3994140625}, {"start": 2625.05, "end": 2625.71, "word": " ال", "probability": 0.65625}, {"start": 2625.71, "end": 2626.31, "word": " cycle", "probability": 0.6728515625}, {"start": 2626.31, "end": 2626.77, "word": " ال", "probability": 0.509765625}, {"start": 2626.77, "end": 2627.51, "word": " number", "probability": 0.90966796875}, {"start": 2627.51, "end": 2627.67, "word": " of", "probability": 0.9501953125}, {"start": 2627.67, "end": 2628.71, "word": " reversals", "probability": 0.892578125}, {"start": 2628.71, "end": 2641.01, "word": " طيب", "probability": 0.8072916666666666}], "temperature": 1.0}, {"id": 95, "seek": 267871, "start": 2651.57, "end": 2678.71, "text": "الـ Total Strain Amplitude اللي هي Delta Epsilon على 2 هتكون مجموع الـ Elastic Strain Amplitude مع الـ Plastic Strain Amplitude و هنعوض عند الـ Elastic اللي هي Sigma F Prime على E في 2N أُس B زائد اللي هي Epsilon F Prime في 2N أُس C", "tokens": [6027, 39184, 23170, 745, 7146, 2012, 564, 4377, 13672, 1829, 39896, 18183, 462, 16592, 15844, 568, 8032, 2655, 30544, 3714, 7435, 2304, 45367, 2423, 39184, 2699, 2750, 745, 7146, 2012, 564, 4377, 20449, 2423, 39184, 2149, 2750, 745, 7146, 2012, 564, 4377, 4032, 8032, 1863, 3615, 2407, 11242, 43242, 2423, 39184, 2699, 2750, 13672, 1829, 39896, 36595, 479, 9655, 15844, 462, 8978, 568, 45, 5551, 10859, 3794, 363, 30767, 16373, 3215, 13672, 1829, 39896, 462, 16592, 479, 9655, 8978, 568, 45, 5551, 10859, 3794, 383], "avg_logprob": -0.19149708713209906, "compression_ratio": 1.702247191011236, "no_speech_prob": 0.0, "words": [{"start": 2651.57, "end": 2652.13, "word": "الـ", "probability": 0.5908203125}, {"start": 2652.13, "end": 2652.33, "word": " Total", "probability": 0.5185546875}, {"start": 2652.33, "end": 2652.87, "word": " Strain", "probability": 0.796875}, {"start": 2652.87, "end": 2653.55, "word": " Amplitude", "probability": 0.970703125}, {"start": 2653.55, "end": 2653.71, "word": " اللي", "probability": 0.5732421875}, {"start": 2653.71, "end": 2653.83, "word": " هي", "probability": 0.896484375}, {"start": 2653.83, "end": 2654.13, "word": " Delta", "probability": 0.5576171875}, {"start": 2654.13, "end": 2654.75, "word": " Epsilon", "probability": 0.6851806640625}, {"start": 2654.75, "end": 2655.25, "word": " على", "probability": 0.6669921875}, {"start": 2655.25, "end": 2655.65, "word": " 2", "probability": 0.66845703125}, {"start": 2655.65, "end": 2656.23, "word": " هتكون", "probability": 0.816162109375}, {"start": 2656.23, "end": 2657.65, "word": " مجموع", "probability": 0.911865234375}, {"start": 2657.65, "end": 2657.85, "word": " الـ", "probability": 0.7239990234375}, {"start": 2657.85, "end": 2658.23, "word": " Elastic", "probability": 0.89990234375}, {"start": 2658.23, "end": 2658.65, "word": " Strain", "probability": 0.913818359375}, {"start": 2658.65, "end": 2659.35, "word": " Amplitude", "probability": 0.97705078125}, {"start": 2659.35, "end": 2660.25, "word": " مع", "probability": 0.912109375}, {"start": 2660.25, "end": 2661.07, "word": " الـ", "probability": 0.6229248046875}, {"start": 2661.07, "end": 2661.53, "word": " Plastic", "probability": 0.95849609375}, {"start": 2661.53, "end": 2662.07, "word": " Strain", "probability": 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"probability": 0.8408203125}, {"start": 2668.79, "end": 2669.19, "word": " E", "probability": 0.8466796875}, {"start": 2669.19, "end": 2669.97, "word": " في", "probability": 0.59033203125}, {"start": 2669.97, "end": 2670.69, "word": " 2N", "probability": 0.84375}, {"start": 2670.69, "end": 2671.31, "word": " أُس", "probability": 0.7134602864583334}, {"start": 2671.31, "end": 2671.69, "word": " B", "probability": 0.7822265625}, {"start": 2671.69, "end": 2673.13, "word": " زائد", "probability": 0.8649088541666666}, {"start": 2673.13, "end": 2673.91, "word": " اللي", "probability": 0.932373046875}, {"start": 2673.91, "end": 2674.13, "word": " هي", "probability": 0.94921875}, {"start": 2674.13, "end": 2674.67, "word": " Epsilon", "probability": 0.8134765625}, {"start": 2674.67, "end": 2675.05, "word": " F", "probability": 0.99267578125}, {"start": 2675.05, "end": 2675.71, "word": " Prime", "probability": 0.7685546875}, {"start": 2675.71, "end": 2676.31, "word": " في", "probability": 0.93212890625}, {"start": 2676.31, "end": 2677.05, "word": " 2N", "probability": 0.987060546875}, {"start": 2677.05, "end": 2677.95, "word": " أُس", "probability": 0.9773763020833334}, {"start": 2677.95, "end": 2678.71, "word": " C", "probability": 0.98681640625}], "temperature": 1.0}, {"id": 96, "seek": 269479, "start": 2688.81, "end": 2694.79, "text": "طيب في الكتاب روحوا appendix A23", "tokens": [9566, 1829, 3555, 8978, 33251, 2655, 16758, 12602, 2407, 5016, 14407, 34116, 970, 316, 9356], "avg_logprob": -0.22033691871911287, "compression_ratio": 0.8571428571428571, "no_speech_prob": 0.0, "words": [{"start": 2688.81, "end": 2689.77, "word": "طيب", "probability": 0.98876953125}, {"start": 2689.77, "end": 2690.83, "word": " في", "probability": 0.64111328125}, {"start": 2690.83, "end": 2691.43, "word": " الكتاب", "probability": 0.9856770833333334}, {"start": 2691.43, "end": 2692.03, "word": " روحوا", "probability": 0.731597900390625}, {"start": 2692.03, "end": 2692.83, "word": " appendix", "probability": 0.8076171875}, {"start": 2692.83, "end": 2694.79, "word": " A23", "probability": 0.779296875}], "temperature": 1.0}, {"id": 97, "seek": 272652, "start": 2696.72, "end": 2726.52, "text": "بيعطيني values of coefficients اللي هي بي بي اللي هو appendix a تلاتة و عشرين في كتاب شغلي بيعطيني اللي هو بي او سي و أبسلن اف برايم او سيجما اف برايم خلنا نشوف هنا ال table نتأكد", "tokens": [21292, 3615, 9566, 1829, 22653, 4190, 295, 31994, 13672, 1829, 39896, 4724, 1829, 4724, 1829, 13672, 1829, 31439, 34116, 970, 257, 6055, 1211, 9307, 3660, 4032, 6225, 46309, 9957, 8978, 9122, 2655, 16758, 13412, 17082, 20292, 4724, 40228, 9566, 1829, 22653, 13672, 1829, 31439, 4724, 1829, 1975, 2407, 8608, 1829, 4032, 5551, 3555, 3794, 1211, 1863, 1975, 5172, 4724, 23557, 32640, 1975, 2407, 8608, 1829, 7435, 15042, 1975, 5172, 4724, 23557, 32640, 16490, 1211, 8315, 8717, 8592, 38688, 34105, 2423, 3199, 8717, 2655, 10721, 4117, 3215], "avg_logprob": -0.24892242201443376, "compression_ratio": 1.6686046511627908, "no_speech_prob": 0.0, "words": [{"start": 2696.72, "end": 2697.3, "word": "بيعطيني", "probability": 0.8107421875}, {"start": 2697.3, "end": 2697.7, "word": " values", "probability": 0.7216796875}, {"start": 2697.7, "end": 2697.92, "word": " of", "probability": 0.98193359375}, {"start": 2697.92, "end": 2698.5, "word": " coefficients", "probability": 0.88720703125}, {"start": 2698.5, "end": 2698.76, "word": " اللي", "probability": 0.7646484375}, {"start": 2698.76, "end": 2698.96, "word": " هي", "probability": 0.765625}, {"start": 2698.96, "end": 2700.46, "word": " بي", "probability": 0.48297119140625}, {"start": 2700.46, "end": 2701.34, "word": " بي", "probability": 0.697998046875}, {"start": 2701.34, "end": 2701.68, "word": " اللي", "probability": 0.780029296875}, {"start": 2701.68, "end": 2701.8, "word": " هو", "probability": 0.9501953125}, {"start": 2701.8, "end": 2702.38, "word": " appendix", "probability": 0.890869140625}, {"start": 2702.38, "end": 2702.76, "word": " a", "probability": 0.433837890625}, {"start": 2702.76, "end": 2704.56, "word": " تلاتة", "probability": 0.8905029296875}, {"start": 2704.56, "end": 2704.66, "word": " و", "probability": 0.96533203125}, {"start": 2704.66, "end": 2705.16, "word": " عشرين", "probability": 0.9161783854166666}, {"start": 2705.16, "end": 2706.62, "word": " في", "probability": 0.85693359375}, {"start": 2706.62, "end": 2707.02, "word": " كتاب", "probability": 0.9962565104166666}, {"start": 2707.02, "end": 2707.58, "word": " شغلي", "probability": 0.7722981770833334}, {"start": 2707.58, "end": 2709.0, "word": " بيعطيني", "probability": 0.8056640625}, {"start": 2709.0, "end": 2709.28, "word": " اللي", "probability": 0.97021484375}, {"start": 2709.28, "end": 2709.54, "word": " هو", "probability": 0.9814453125}, {"start": 2709.54, "end": 2711.3, "word": " بي", "probability": 0.83056640625}, {"start": 2711.3, "end": 2711.7, "word": " او", "probability": 0.6883544921875}, {"start": 2711.7, "end": 2712.78, "word": " سي", "probability": 0.6749267578125}, {"start": 2712.78, "end": 2714.06, "word": " و", "probability": 0.84912109375}, {"start": 2714.06, "end": 2714.64, "word": " أبسلن", "probability": 0.7095703125}, {"start": 2714.64, "end": 2714.92, "word": " اف", "probability": 0.742919921875}, {"start": 2714.92, "end": 2715.52, "word": " برايم", "probability": 0.7084147135416666}, {"start": 2715.52, "end": 2716.78, "word": " او", "probability": 0.818115234375}, {"start": 2716.78, "end": 2717.3, "word": " سيجما", "probability": 0.7978515625}, {"start": 2717.3, "end": 2717.9, "word": " اف", "probability": 0.9013671875}, {"start": 2717.9, "end": 2718.74, "word": " برايم", "probability": 0.9744466145833334}, {"start": 2718.74, "end": 2719.06, "word": " خلنا", "probability": 0.644775390625}, {"start": 2719.06, "end": 2719.36, "word": " نشوف", "probability": 0.9905598958333334}, {"start": 2719.36, "end": 2719.76, "word": " هنا", "probability": 0.4697265625}, {"start": 2719.76, "end": 2720.78, "word": " ال", "probability": 0.87890625}, {"start": 2720.78, "end": 2721.7, "word": " table", "probability": 0.403076171875}, {"start": 2721.7, "end": 2726.52, "word": " نتأكد", "probability": 0.96005859375}], "temperature": 1.0}, {"id": 98, "seek": 275765, "start": 2738.71, "end": 2757.65, "text": "هذا table A23 زي ما انتوا شايفين ال headings اتطلعوا على أقصى يمين ال table عند ال fatigue strength exponent B موجود و ال fatigue ductility exponent C موجود و ال fatigue ductility coefficient F prime موجود", "tokens": [3224, 15730, 3199, 316, 9356, 30767, 1829, 19446, 16472, 2655, 14407, 13412, 995, 33911, 9957, 2423, 1378, 1109, 1975, 2655, 9566, 1211, 3615, 14407, 15844, 5551, 4587, 9381, 7578, 7251, 2304, 9957, 2423, 3199, 43242, 2423, 20574, 3800, 37871, 363, 3714, 29245, 23328, 4032, 2423, 20574, 25954, 1140, 37871, 383, 3714, 29245, 23328, 4032, 2423, 20574, 25954, 1140, 17619, 479, 5835, 3714, 29245, 23328], "avg_logprob": -0.20588942307692307, "compression_ratio": 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42778, 15844, 8032, 30544, 2423, 12771, 42778, 15844, 257], "avg_logprob": -0.5438987981705439, "compression_ratio": 1.4202898550724639, "no_speech_prob": 0.0, "words": [{"start": 4177.54, "end": 4177.96, "word": "ان", "probability": 0.2120361328125}, {"start": 4177.96, "end": 4178.96, "word": " اسمي", "probability": 0.559326171875}, {"start": 4178.96, "end": 4181.44, "word": " يعني", "probability": 0.784423828125}, {"start": 4181.44, "end": 4182.04, "word": " هتكون", "probability": 0.8606770833333334}, {"start": 4182.04, "end": 4182.32, "word": " ال", "probability": 0.50439453125}, {"start": 4182.32, "end": 4182.62, "word": " sigma", "probability": 0.6240234375}, {"start": 4182.62, "end": 4184.12, "word": " reversal", "probability": 0.10870361328125}, {"start": 4184.12, "end": 4185.42, "word": " على", "probability": 0.744140625}, {"start": 4185.42, "end": 4198.3, "word": " هكون", "probability": 0.5885009765625}, {"start": 4198.3, "end": 4198.42, "word": " ال", "probability": 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"probability": 0.998046875}, {"start": 4577.44, "end": 4578.06, "word": " خمسين", "probability": 0.944091796875}, {"start": 4578.06, "end": 4581.52, "word": " hot", "probability": 0.830078125}, {"start": 4581.52, "end": 4582.72, "word": " rolled", "probability": 0.71533203125}], "temperature": 1.0}, {"id": 166, "seek": 461184, "start": 4584.9, "end": 4611.84, "text": "steel طالع عندى هنا في جدول عندى الف و خمسين في quenched and timbered في تلت أنواع quenched and timbered هين معطيني درجة الحرارة هين عندى normalized عندين annealed", "tokens": [2941, 338, 23032, 6027, 3615, 43242, 7578, 34105, 8978, 10874, 3215, 12610, 43242, 7578, 27188, 4032, 16490, 2304, 3794, 9957, 8978, 421, 268, 19318, 293, 34671, 292, 8978, 6055, 1211, 2655, 14739, 14407, 3615, 421, 268, 19318, 293, 34671, 292, 8032, 9957, 20449, 9566, 9957, 1829, 11778, 47341, 3660, 21542, 2288, 9640, 3660, 8032, 9957, 43242, 7578, 48704, 43242, 9957, 22256, 5573], "avg_logprob": -0.27256945579771014, "compression_ratio": 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بيعطينا ال .. ال tensile strength سبعمية وسبعتاش normalized سبعمية و تمانية واربعين and yield ستمية وستة", "tokens": [1211, 39319, 19913, 14407, 421, 268, 19318, 293, 3393, 292, 43242, 5551, 25513, 25957, 16373, 3660, 8978, 3224, 2288, 7649, 4386, 43242, 44650, 9957, 4032, 9778, 2304, 3794, 8978, 3224, 2288, 7649, 11296, 1829, 39894, 3615, 9566, 1829, 8315, 2423, 4386, 2423, 4386, 2423, 4386, 2423, 9705, 10688, 794, 3800, 27188, 4032, 2304, 10632, 4032, 3615, 46309, 9957, 43242, 5551, 25513, 25957, 16373, 3660, 4032, 9778, 2304, 3794, 3660, 4032, 3615, 46309, 8978, 3224, 2288, 7649, 11296, 1829, 39894, 3615, 9566, 1829, 8315, 27188, 4032, 2655, 3794, 3615, 9957, 43242, 8608, 3555, 25957, 10632, 4032, 35457, 34268, 33599, 4724, 40228, 9566, 1829, 8315, 2423, 4386, 2423, 10688, 794, 3800, 8608, 3555, 25957, 10632, 4032, 35457, 34268, 33599, 48704, 8608, 3555, 25957, 10632, 4032, 46811, 7649, 10632, 4032, 9640, 3555, 3615, 9957, 293, 11257, 8608, 39237, 10632, 4032, 14851, 3660], 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"probability": 0.98828125}, {"start": 5610.35, "end": 5610.91, "word": " هو", "probability": 0.9208984375}, {"start": 5610.91, "end": 5611.69, "word": " بيقدر", "probability": 0.872802734375}, {"start": 5611.69, "end": 5612.25, "word": " انه", "probability": 0.71484375}, {"start": 5612.25, "end": 5612.61, "word": " I", "probability": 0.267333984375}, {"start": 5612.61, "end": 5612.93, "word": " need", "probability": 0.95703125}, {"start": 5612.93, "end": 5614.17, "word": " محتاج", "probability": 0.8129069010416666}, {"start": 5614.17, "end": 5614.49, "word": " انا", "probability": 0.670166015625}, {"start": 5614.49, "end": 5614.93, "word": " اعمل", "probability": 0.9542643229166666}, {"start": 5614.93, "end": 5615.53, "word": " modification", "probability": 0.8818359375}, {"start": 5615.53, "end": 5616.69, "word": " بنسبة", "probability": 0.8444010416666666}, {"start": 5616.69, "end": 5616.95, "word": " 50", "probability": 0.5341796875}, {"start": 5616.95, "end": 5617.25, "word": "%", 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\ No newline at end of file
diff --git a/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/Y3Um_iLIIhU_raw.srt b/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/Y3Um_iLIIhU_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..e5d3b140fe111666fc14a1eee70c37afdec57ddc
--- /dev/null
+++ b/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/Y3Um_iLIIhU_raw.srt
@@ -0,0 +1,3820 @@
+1
+00:00:04,980 --> 00:00:08,020
+السلام عليكم بسم الله الرحمن الرحيم اليوم هنبدأ
+
+2
+00:00:08,020 --> 00:00:11,900
+chapter جديد اللي هو fatigue failure resulting
+
+3
+00:00:11,900 --> 00:00:16,280
+from variable loading اللي هو انهيارات او فشل في
+
+4
+00:00:16,280 --> 00:00:21,240
+القطع الميكانيكية الناتجة عن الأحمال المتغيرة في
+
+5
+00:00:21,240 --> 00:00:26,800
+chapter خمسة غطينا الانهيارات في القطع الميكانيكية
+
+6
+00:00:26,800 --> 00:00:32,860
+الناتجة عن الأحمال الثابتةالموضوعات اللى هنغطيها
+
+7
+00:00:32,860 --> 00:00:36,880
+فى ال chapter هذا اللى هى مقدمة و تعريفات متعلقة
+
+8
+00:00:36,880 --> 00:00:41,360
+بالاجهاد المتواتر فى المعادن اللى هو fatigue in
+
+9
+00:00:41,360 --> 00:00:46,060
+metals ال methodological approach to fatigue
+
+10
+00:00:46,060 --> 00:00:51,120
+failure فى عملية التحليل و التصميم طرق حسابات
+
+11
+00:00:51,120 --> 00:00:54,500
+لاجهاد المتواتر fatigue life method اللى هى stress
+
+12
+00:00:54,500 --> 00:00:57,500
+life method و strain life method و linear elastic
+
+13
+00:00:57,500 --> 00:01:02,950
+fracture mechanics methodهنتعرف على ال endurance
+
+14
+00:01:02,950 --> 00:01:07,930
+limit الفتيك strength و بعدين how to modify
+
+15
+00:01:07,930 --> 00:01:14,290
+endurance limit of a standard فتيك specimen عشان
+
+16
+00:01:14,290 --> 00:01:18,330
+اخد فعل اعتبار المتغيرات الأخرى الواقعية وبالتالي
+
+17
+00:01:18,330 --> 00:01:22,450
+هنتطرق لل endurance limit modifying factors هنتعرف
+
+18
+00:01:22,450 --> 00:01:27,110
+على التركيز الإجهادي وحساسية المادة للخدوش
+
+19
+00:01:34,250 --> 00:01:38,810
+بعدين هنتعرف ناخد اللى هو بشكل عام ال .. ال .. how
+
+20
+00:01:38,810 --> 00:01:43,170
+to characterize ال .. ال .. ال variability فى ال
+
+21
+00:01:43,170 --> 00:01:47,650
+loading ممكن نوع ال loading يكون عندى ال .. يكون
+
+22
+00:01:47,650 --> 00:01:50,350
+عندى tensile loading أو bending loading أو
+
+23
+00:01:50,350 --> 00:01:53,230
+torsional loading أو any combination how to
+
+24
+00:01:53,230 --> 00:01:57,610
+characterize ال loading into one stress component
+
+25
+00:01:57,610 --> 00:02:00,710
+مع استخدام اللى هى ال design theories
+
+26
+00:02:03,880 --> 00:02:08,720
+نبدأ اولش اللي هو تقديم او بعض التقديم لل fatigue
+
+27
+00:02:08,720 --> 00:02:19,700
+in metals اول ملاحظة ال loading ممكن يكون متغير او
+
+28
+00:02:19,700 --> 00:02:26,380
+متكرر يعني مثلا لو اخدت انا الزنبارك في السيارة
+
+29
+00:02:26,380 --> 00:02:31,880
+عند هذه السيارة هذه
+
+30
+00:02:31,880 --> 00:02:38,010
+العجلاتو فى عندى هى نظام التعليق هنعمل صورة رسمها
+
+31
+00:02:38,010 --> 00:02:52,270
+أكبر وهى
+
+32
+00:02:52,270 --> 00:02:58,930
+عندى هى دولاب هى دولاب هى أكس و فى عندى نظام
+
+33
+00:02:58,930 --> 00:03:00,170
+التعليق زمبركات
+
+34
+00:03:04,730 --> 00:03:10,810
+الان السيارة و هي ماشية ال loading او التحميل على
+
+35
+00:03:10,810 --> 00:03:15,990
+الزنبارك بيكون متغير الان انا ممكن اكون ماشي على
+
+36
+00:03:15,990 --> 00:03:20,750
+أرض سهلية ممكن اطلع مطاب ممكن انزل عجورة فهذه
+
+37
+00:03:20,750 --> 00:03:27,130
+السلحة تزاد و بتعمل تغيير على الأحمال على الزنبارك
+
+38
+00:03:27,130 --> 00:03:34,000
+فممكن الأحمال ماتكونش ثابتةتكون متغيرة هذا يسمى
+
+39
+00:03:34,000 --> 00:03:41,880
+variable variable loading مثال تاني ممكن لو أخدنا
+
+40
+00:03:41,880 --> 00:03:49,940
+عضلة قلب الإنسان عضل قلب الإنسان التحميل عليها
+
+41
+00:03:49,940 --> 00:03:53,460
+متغير و ممكن نعمل إشي زي هيك
+
+42
+00:03:59,370 --> 00:04:06,550
+واضح انه ال loading variable
+
+43
+00:04:06,550 --> 00:04:10,530
+فمعناته
+
+44
+00:04:10,530 --> 00:04:15,370
+التحميل مش ثابت طبعا في امثلة كتير في ال engine
+
+45
+00:04:15,370 --> 00:04:26,970
+بتاع السيارة عند ال slider crank mechanism عند
+
+46
+00:04:26,970 --> 00:04:31,090
+هناالـ Piston بتاع السيارة لو أخدت ال connecting
+
+47
+00:04:31,090 --> 00:04:36,690
+rod ال connecting rod
+
+48
+00:04:36,690 --> 00:04:42,390
+طبعا ال anger velocity و ال anger acceleration لل
+
+49
+00:04:42,390 --> 00:04:48,070
+connecting rod متغيرة معناته ال inertia forces على
+
+50
+00:04:48,070 --> 00:04:51,510
+ال connecting rod متغيرة معناته ال loading متغيرة
+
+51
+00:04:51,510 --> 00:04:55,550
+فهيكون التحميل على ال connecting rod متغير
+
+52
+00:04:58,310 --> 00:05:02,750
+لأن في حالة القطع الميكانيكية المتعرضة لأحمال
+
+53
+00:05:02,750 --> 00:05:07,550
+متغيرة ممكن يصير ال failure ال mechanical element
+
+54
+00:05:07,550 --> 00:05:13,950
+عند stress أقل من ال lead strength لأن ال failure
+
+55
+00:05:13,950 --> 00:05:19,830
+بيصير بعد تكرار اكتئع عدد كبير من ال cycles of
+
+56
+00:05:19,830 --> 00:05:27,490
+variable loading ال failure عادة بيكونبالنسبة لنا
+
+57
+00:05:27,490 --> 00:05:33,050
+بيصيرنا كسر مفاجئ ومابيعطينيش تحذير مسبق انه هيصير
+
+58
+00:05:33,050 --> 00:05:35,810
+كسر بس وفي الحقيقة بيكون فيه ال failure اللي فترة
+
+59
+00:05:35,810 --> 00:05:42,410
+بدي بس انا اللي بشوفه كمستخدم بشوف فجأة انه صار
+
+60
+00:05:42,410 --> 00:05:52,330
+عندى كسر او failure بدون انظار مسبق ال
+
+61
+00:05:52,330 --> 00:05:54,990
+fatigue failure بيمرر تلت مراحل
+
+62
+00:06:00,250 --> 00:06:07,050
+اللي هو عندي three stages of
+
+63
+00:06:07,050 --> 00:06:14,210
+fatigue failure أول
+
+64
+00:06:14,210 --> 00:06:23,530
+مرحلة اللي هي crack initiation بعدين
+
+65
+00:06:23,530 --> 00:06:25,310
+crack propagation
+
+66
+00:06:29,630 --> 00:06:39,030
+بعدين اللي هو final ultimate fracture
+
+67
+00:06:39,030 --> 00:06:44,730
+يعني
+
+68
+00:06:44,730 --> 00:06:51,160
+في الأول تجدال repeated stress عن نقطة معينة ممكن
+
+69
+00:06:51,160 --> 00:06:54,360
+locally ادخل ال plastic range locally ادخل ال
+
+70
+00:06:54,360 --> 00:06:59,920
+plastic range يعني انا رسمت ال material ال stress
+
+71
+00:06:59,920 --> 00:07:04,580
+versus ال strain لحديد معين ممكن يكون الشكل هذا
+
+72
+00:07:04,580 --> 00:07:09,640
+ممكن انا local اكون في المنطقة هذه ادخل ادخل اللي
+
+73
+00:07:09,640 --> 00:07:14,040
+هو في ال plasticعن نقطة معينة إذا خدت لـ plastic
+
+74
+00:07:14,040 --> 00:07:17,740
+range عن نقطة معينة بيبدأ يصير تشقق بيبدأ يصير
+
+75
+00:07:17,740 --> 00:07:21,160
+عنده تشقق مع ال repetition of loading بيبدأ يصير
+
+76
+00:07:21,160 --> 00:07:25,140
+تشقق فالمرحلة اللي بسميها اللي هي بداية التشقق أو
+
+77
+00:07:25,140 --> 00:07:29,860
+crack initiation طبعا ال stress cycling مستمر
+
+78
+00:07:29,860 --> 00:07:34,980
+فبيبدأ ال crack ايش؟ توسع، تكبر، تزيد شوي شوي شوي
+
+79
+00:07:34,980 --> 00:07:37,540
+شوي شوي شوي شوي شوي شوي شوي شوي شوي شوي شوي شوي
+
+80
+00:07:37,540 --> 00:07:39,570
+شوي شوي شوي شوي شوي شوي شوي شوي شوي شويلحد ما ال
+
+81
+00:07:39,570 --> 00:07:43,130
+material اللي حقيقة حمض ال load او المقطع الحقيقي
+
+82
+00:07:43,130 --> 00:07:47,570
+بيقل حجمه لحد ما ال cross section يضعف شكل كبير و
+
+83
+00:07:47,570 --> 00:07:55,350
+يصير failure من خلال انه ال stress وصل ل ال
+
+84
+00:07:55,350 --> 00:07:58,330
+ultimate stress في ال material لان ال area ما لها
+
+85
+00:07:58,330 --> 00:08:06,130
+قلت و ال stress sigma بيساوي F على A يعني كل ما
+
+86
+00:08:06,130 --> 00:08:14,290
+تقل Aكل ما اتقل ال stress اشماله بزيد فحتصل مرحلة
+
+87
+00:08:14,290 --> 00:08:18,410
+انه ال cross section area صغر كتير فبنوصل ل ال
+
+88
+00:08:18,410 --> 00:08:26,150
+ultimate strength فبصير sudden failure انا
+
+89
+00:08:26,150 --> 00:08:29,430
+عندي هنا امثلة على fatigue failure في عندى shaft
+
+90
+00:08:29,430 --> 00:08:34,230
+عمودو فى عندى هنا key way عند ال key way فى عندى
+
+91
+00:08:34,230 --> 00:08:37,150
+sudden change فى ال cross section معناته هيصير
+
+92
+00:08:37,150 --> 00:08:40,370
+عندى stress concentration stress concentration
+
+93
+00:08:40,370 --> 00:08:44,110
+يعني ال stress level عند ال discontinuity هيرفع
+
+94
+00:08:44,110 --> 00:08:48,810
+بشكل كبير يعني هكون عندى ال stress بعيد عن النقطة
+
+95
+00:08:48,810 --> 00:08:53,910
+هذه مثلا يكون 100 ميجا لكن عندى stress
+
+96
+00:08:53,910 --> 00:08:57,710
+concentration factor هنا تلاتة معناته locally هكون
+
+97
+00:08:57,710 --> 00:09:03,540
+ال stress 300300 ميجا معناته انا ممكن اكون دخلت ال
+
+98
+00:09:03,540 --> 00:09:08,340
+plastic region فتبدأ عند هنا بيصير ايش ال crack ال
+
+99
+00:09:08,340 --> 00:09:10,980
+crack بتنتشر شوية شوية شوية شوية شوية شوية شوية
+
+100
+00:09:10,980 --> 00:09:14,820
+شوية لحد ما ال cross section يصغر بشكل كبير كتير
+
+101
+00:09:14,820 --> 00:09:18,760
+برفع ال stress level بشكل مفاجئ و بيصير كسر by
+
+102
+00:09:18,760 --> 00:09:22,380
+ultimate by ultimate tensile failure
+
+103
+00:09:30,050 --> 00:09:36,050
+الان في عندى ال three major fatigue life models في
+
+104
+00:09:36,050 --> 00:09:41,290
+عندى تلاتة models لتحليل الإجهادات المتواترة هذه
+
+105
+00:09:41,290 --> 00:09:48,570
+الطرق ال methods بتتوقع عمر القطعة بال cycles for
+
+106
+00:09:48,570 --> 00:09:53,770
+a certain loading level يعني كل الطرق هذهبتتوقع
+
+107
+00:09:53,770 --> 00:10:01,450
+عمر القطع الميكانيكية and لتحميل معين مثلا عند ميت
+
+108
+00:10:01,450 --> 00:10:07,150
+ميجا باسكال ممكن القطع هتتعيش مثلا مليون .. مليون
+
+109
+00:10:07,150 --> 00:10:13,590
+cycle عند متين ميجا باسكال ممكن تعيش تلتميت ألف
+
+110
+00:10:13,590 --> 00:10:14,790
+cycle و هكذا
+
+111
+00:10:23,230 --> 00:10:25,710
+الان ال fatigue life method يعني ال stress life
+
+112
+00:10:25,710 --> 00:10:28,290
+method و ال strain life method و ال linear elastic
+
+113
+00:10:28,290 --> 00:10:32,450
+fracture mechanics method احنا في ال course هذا
+
+114
+00:10:32,450 --> 00:10:35,830
+هنتعطى .. او هنتطرق للطريقة الأولى و الطريقة
+
+115
+00:10:35,830 --> 00:10:38,970
+التانية اللي هي ال stress life method و ال strain
+
+116
+00:10:38,970 --> 00:10:44,570
+life method في
+
+117
+00:10:44,570 --> 00:10:50,710
+ال stress life method بحضر عينة معيارية اللي لها
+
+118
+00:10:50,710 --> 00:10:56,760
+شكل معين ابعاد معينةوبعرضها ل repeating stress
+
+119
+00:10:56,760 --> 00:11:01,080
+while counting cycles to failure بعرضها دي ل
+
+120
+00:11:01,080 --> 00:11:07,200
+building stress ال building طبعا أشمله متغير بضع
+
+121
+00:11:07,200 --> 00:11:11,840
+نعملها building و أعد number of cycles لحد ما
+
+122
+00:11:11,840 --> 00:11:19,340
+العينة تنكسر طبعا طبيعة ال loading completely
+
+123
+00:11:19,340 --> 00:11:21,440
+reverse stress cycling ايش يعني completely
+
+124
+00:11:21,440 --> 00:11:22,560
+reversed يعني
+
+125
+00:11:30,070 --> 00:11:41,930
+يعني انا اخدت fiber هنا المقطع هنا هكون دائر في
+
+126
+00:11:41,930 --> 00:11:44,370
+لحظة معينة انا ممكن يكون عندي هنا ال fiber هذه
+
+127
+00:11:44,370 --> 00:11:49,820
+بالشكل هذاعندي هكون عليها شد tension هان tension
+
+128
+00:11:49,820 --> 00:11:54,240
+إذا بلف تسعين درجة النقطة هادي هصير هان هصير عندي
+
+129
+00:11:54,240 --> 00:11:59,580
+ال stress zero بلف كمان تسعين درجة بصير نقطة بتلف
+
+130
+00:11:59,580 --> 00:12:06,140
+تحت بصير عليها compression انضغاطبلف كمان تسعين
+
+131
+00:12:06,140 --> 00:12:09,460
+درجة zero كمان تسعين درجة tension بمعناته ان عندي
+
+132
+00:12:09,460 --> 00:12:13,840
+tension is zero tension is zero compression is
+
+133
+00:12:13,840 --> 00:12:17,620
+zero tension is zero compression وهكذا بمعناته
+
+134
+00:12:17,620 --> 00:12:21,880
+complete reverse ممكن نفس ال fiber يكون على مرة في
+
+135
+00:12:21,880 --> 00:12:24,920
+لحظة ما tension في لحظة ما compression لأنه بيكون
+
+136
+00:12:24,920 --> 00:12:30,160
+عندي bending بالشكل هذا طبعا
+
+137
+00:12:30,160 --> 00:12:38,600
+بغير ال loading طبعا في setupلجهاز اللى .. لل
+
+138
+00:12:38,600 --> 00:12:41,660
+fatigue tensile test طبعا هذا ال fatigue tensile
+
+139
+00:12:41,660 --> 00:12:45,120
+test اتعرفنا عليه من خلال course ال material
+
+140
+00:12:45,120 --> 00:12:48,640
+science و ال course mechanics of material اتعرضنا
+
+141
+00:12:48,640 --> 00:12:57,540
+بالتفصيل كيف نعمل الفحص طبعا عندي هى العينة عندي
+
+142
+00:12:57,540 --> 00:13:00,880
+هى العينة او في عندي one set up عندي هى العينة
+
+143
+00:13:00,880 --> 00:13:06,070
+مثبتة فاندي هنا main bearingهنا main bearing وهنا
+
+144
+00:13:06,070 --> 00:13:10,150
+لدي flexible coupling بتوصل العمود هذا مع الموتور
+
+145
+00:13:10,150 --> 00:13:14,690
+اللي بلف لأن هنا في وزن بيكون تحميل على ال bearing
+
+146
+00:13:14,690 --> 00:13:18,010
+هذه و ال bearing هذا لأن نتيجة تحميل الشد لتحت
+
+147
+00:13:18,010 --> 00:13:22,850
+هصير عندي ال fiber هنا عليها compression وهنا
+
+148
+00:13:22,850 --> 00:13:30,090
+tension لأن ال shaft بيكونهي دور معناته هذه كانت
+
+149
+00:13:30,090 --> 00:13:32,350
+في اللحظة ال compression لما يلف مئتين درجة بيصير
+
+150
+00:13:32,350 --> 00:13:35,750
+ال tension كمان مئتين درجة compression tension
+
+151
+00:13:35,750 --> 00:13:37,890
+compression tension compression tension و هكذا
+
+152
+00:13:37,890 --> 00:13:42,870
+فبصير نفس ال fiber ال stress level is completely
+
+153
+00:13:42,870 --> 00:13:49,450
+reversed bending اللي هو بالشكل هذا هذا one setup
+
+154
+00:13:49,450 --> 00:13:58,970
+another setup العينة تمسكمن طرف بالعمود بتاع
+
+155
+00:13:58,970 --> 00:14:03,170
+الموتور فيندي هنا موتور و فيندي هنا bearing و
+
+156
+00:14:03,170 --> 00:14:07,550
+فيندي bearing الان العمود العينة موجودة في bearing
+
+157
+00:14:07,550 --> 00:14:11,650
+و ال bearing انا سامحلها ت slide و هنا بكون حاطط
+
+158
+00:14:11,650 --> 00:14:15,230
+load عليها لأن نتيجة ال load حاسس ان عند المنطقة
+
+159
+00:14:15,230 --> 00:14:15,530
+هذه
+
+160
+00:14:18,330 --> 00:14:23,490
+Tension, bending, stress إذا بقى لف تسعين درجة
+
+161
+00:14:23,490 --> 00:14:26,650
+يعني إذا بقى لف ال fiber هتبصير تحت هتصير
+
+162
+00:14:26,650 --> 00:14:30,150
+compression فهو الشخص بدور مرة tension compression
+
+163
+00:14:30,150 --> 00:14:32,290
+tension compression tension compression وكذا
+
+164
+00:14:32,290 --> 00:14:38,240
+فهيكون completely reversed bendingstress لحد الكسر
+
+165
+00:14:38,240 --> 00:14:41,680
+طبعا انا في التجربة بغير ال load مثلا بحط أول 200
+
+166
+00:14:41,680 --> 00:14:47,220
+kilo بحط مثلا خمس مثلا عشرة kilogram و بلف الموتور
+
+167
+00:14:47,220 --> 00:14:51,820
+لما حد العينة ما تنكسر بجيب عينة تانية بحط ال load
+
+168
+00:14:51,820 --> 00:14:58,900
+مثلا مية بلف العينة لحد بعد number of cycles لحد
+
+169
+00:14:58,900 --> 00:15:05,410
+الكسر بحطعينة تالتة بحط load مثلا متين عينة رابعة
+
+170
+00:15:05,410 --> 00:15:08,850
+بحط load اربع تلات مية اربع مية يعني ماناتي انا
+
+171
+00:15:08,850 --> 00:15:13,310
+بحط ال load مثلا
+
+172
+00:15:13,310 --> 00:15:23,290
+سفر مية متين تلات مية و ا count cycles to failure
+
+173
+00:15:30,450 --> 00:15:35,610
+و بعدين بحسب ال .. ال .. ال fatigue strength ال
+
+174
+00:15:35,610 --> 00:15:41,090
+fatigue strength اذا عندي cantilever انا و عندي
+
+175
+00:15:41,090 --> 00:15:47,730
+shaft و في load هنا F هذه المسافة L
+
+176
+00:15:50,580 --> 00:15:55,880
+الـ moment هيكون ايش اساوي؟ الـ moment هيساوي F L
+
+177
+00:15:55,880 --> 00:16:02,640
+و المقطع عندى مدور معناته ال sigma هتكون اساوي M
+
+178
+00:16:02,640 --> 00:16:12,770
+في C على I ال M عندى F L و ال C D على 2قطر العمود
+
+179
+00:16:12,770 --> 00:16:18,270
+على اتنين وال I باي على اربع ستين في دي اص اربعة
+
+180
+00:16:18,270 --> 00:16:26,190
+يعني ال sigma هتكون ساوية اتنين و تلاتين FL على
+
+181
+00:16:26,190 --> 00:16:31,590
+باي دي تكيب هذا هي basically هذا ال stress او تسمي
+
+182
+00:16:31,590 --> 00:16:35,850
+ال stress amplitude لان ال stress هيتغير بالشكل
+
+183
+00:16:35,850 --> 00:16:39,230
+هذا هذا ال stress
+
+184
+00:16:43,680 --> 00:16:48,200
+amplitude انا اللي بقيس بقيس ال force و اعرف
+
+185
+00:16:48,200 --> 00:16:53,940
+المسافة هذه بحسب ال moment و بعدين بحسب من ما
+
+186
+00:16:53,940 --> 00:16:57,340
+عرفتي ده ال force و ال L و نصف و القطر بحسب ال
+
+187
+00:16:57,340 --> 00:17:02,320
+stress level طبعا بكون معرض القطع او العينة ل
+
+188
+00:17:02,320 --> 00:17:06,620
+certain load F و بعد ال cycles to failure بعدين
+
+189
+00:17:06,620 --> 00:17:07,400
+بعمل plot
+
+190
+00:17:10,770 --> 00:17:15,670
+اللي هو ال .. ال .. ال fatigue strength مع ال
+
+191
+00:17:15,670 --> 00:17:19,430
+cycles to failure بعمل plot على log .. log scale
+
+192
+00:17:19,430 --> 00:17:22,770
+يعني دي هين log scale و هين دي log scale يعني مثلا
+
+193
+00:17:22,770 --> 00:17:26,150
+دي هين عشر قص سفر عشر قص واحد عشر قص اتنين عشر قص
+
+194
+00:17:26,150 --> 00:17:29,870
+تلاتة عشر قص أربع عشر قص خمسة قص ستة قص سبعة و هين
+
+195
+00:17:29,870 --> 00:17:33,570
+عندي لأ semi log scale يعني هين ال .. ال .. ال ..
+
+196
+00:17:33,570 --> 00:17:37,230
+المحر أفق log scale و هين عشر linear scale عندي
+
+197
+00:17:37,230 --> 00:17:50,520
+هين مثلا خمسينمية و هكذا لللحظة
+
+198
+00:17:50,520 --> 00:17:56,720
+هلو سمي ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+199
+00:17:56,720 --> 00:17:59,180
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+200
+00:17:59,180 --> 00:18:01,980
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+201
+00:18:01,980 --> 00:18:03,320
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+202
+00:18:03,320 --> 00:18:03,500
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+203
+00:18:03,500 --> 00:18:03,500
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+204
+00:18:03,500 --> 00:18:03,560
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+205
+00:18:03,560 --> 00:18:03,560
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+206
+00:18:03,560 --> 00:18:03,560
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+207
+00:18:03,560 --> 00:18:03,560
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+208
+00:18:03,560 --> 00:18:03,560
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+209
+00:18:03,560 --> 00:18:03,560
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+210
+00:18:03,560 --> 00:18:08,150
+ال ال ال ال الاللي هي number of stress cycles على
+
+211
+00:18:08,150 --> 00:18:12,250
+المحور الرأسي الاسفة ال fatigue strength ال
+
+212
+00:18:12,250 --> 00:18:17,990
+fatigue strength هلاحظ انه لل .. لل .. لل ..
+
+213
+00:18:17,990 --> 00:18:24,710
+للحديد هكون شكل ال stress strain curve بالشكل هذا
+
+214
+00:18:24,710 --> 00:18:34,040
+بشكل عام .. بشكل عام كل ما بزيد ال stress levelكل
+
+215
+00:18:34,040 --> 00:18:39,920
+ما اكيد محتاج ل number of cycles to failure اقل او
+
+216
+00:18:39,920 --> 00:18:43,820
+بمعنى كل ما بقل ال stress level كل ما ال cycles to
+
+217
+00:18:43,820 --> 00:18:47,200
+failure اشملها بزيد يعني اذا بزيد ال stress level
+
+218
+00:18:47,200 --> 00:18:53,000
+او ال load level ال cycles to failure بتقل او لو
+
+219
+00:18:53,000 --> 00:18:57,180
+بدي احكيها بالعكس كل ما قل ال stress level كل ما
+
+220
+00:18:57,180 --> 00:19:00,080
+ال cycles to failure بزيد
+
+221
+00:19:03,000 --> 00:19:08,840
+الان في عندى لحظة هذه عشرة اقصد تلاتة هذه الف هنا
+
+222
+00:19:08,840 --> 00:19:15,320
+تقريبا عشرة اقصد ستة هنا عشرة اقصد سبعة عشرة اقصد
+
+223
+00:19:15,320 --> 00:19:19,020
+تمانية عشرة اقصد ستة يعني مليون cycle عشرة اقصد
+
+224
+00:19:19,020 --> 00:19:21,340
+سبعة عشرة مليون cycle عشرة اقصد تمانية اللى هو ميت
+
+225
+00:19:21,340 --> 00:19:24,860
+مليون cycle عشرة اقصد تلاتة الف cycle
+
+226
+00:19:29,270 --> 00:19:34,350
+الان انا ممكن اصنف او اعمل تصنيفات على ال curve
+
+227
+00:19:34,350 --> 00:19:42,310
+بطرق مختلفة ممكن to define low cycle fatigue يعني
+
+228
+00:19:42,310 --> 00:19:52,850
+عندي هنا low cycle fatigue من
+
+229
+00:19:52,850 --> 00:19:57,030
+هنا لهنا وعندي
+
+230
+00:20:00,030 --> 00:20:11,070
+هنا عندي high cycle fatigue low
+
+231
+00:20:11,070 --> 00:20:16,130
+cycle fatigue بيصير failure او المنطقة اللى بيكون
+
+232
+00:20:16,130 --> 00:20:19,210
+عدد ال number of cycles to failure اقل من الف
+
+233
+00:20:19,210 --> 00:20:24,940
+حياتي بتسميها low cycle fatigue اذا كانعدد ال
+
+234
+00:20:24,940 --> 00:20:28,780
+cycles to failure أكتر من ألف أسميه high cycle
+
+235
+00:20:28,780 --> 00:20:32,820
+fatigue هاي الطريقة لأنه لو عندي low cycle fatigue
+
+236
+00:20:32,820 --> 00:20:35,880
+وعندي high cycle fatigue low cycle fatigue ال
+
+237
+00:20:35,880 --> 00:20:39,800
+number of cycles to failure أقل من ألف high cycle
+
+238
+00:20:39,800 --> 00:20:45,960
+fatigue ال cycles to failure أكتر من ألف ممكن
+
+239
+00:20:45,960 --> 00:20:46,840
+تصنيف تاني
+
+240
+00:21:07,460 --> 00:21:20,080
+ممكن احكي finite life fatigue وهين اللي هو high او
+
+241
+00:21:20,080 --> 00:21:25,600
+infinite life
+
+242
+00:21:25,600 --> 00:21:29,460
+fatigue يعني
+
+243
+00:21:31,750 --> 00:21:36,050
+لحد مليون cycle بعتبر ان القطع لها عمر محدود
+
+244
+00:21:36,050 --> 00:21:42,470
+finite life يعني اذا تجاوزت المليون cycle تقريب
+
+245
+00:21:42,470 --> 00:21:45,690
+بعتبر ان حياتها infinite life لو اعتبر حياتها
+
+246
+00:21:45,690 --> 00:21:51,050
+infinite life الان
+
+247
+00:21:51,050 --> 00:21:56,790
+لو نخد مثال على عدد الضربات او عدد التغير لقطع
+
+248
+00:21:56,790 --> 00:22:00,670
+ميكانيكية معينة خد مثلا عضلة القلب عضلة القلب
+
+249
+00:22:05,460 --> 00:22:10,200
+عضة القلب تعمل سبعين ضربة في الدقيقة .. سبعين ضربة
+
+250
+00:22:10,200 --> 00:22:16,460
+في الدقيقة يعني
+
+251
+00:22:16,460 --> 00:22:22,680
+في الساعة .. كم في الساعة؟ في الساعة يكون سبعين في
+
+252
+00:22:22,680 --> 00:22:29,360
+ستين بيطلع أربع تلاف و متين ضربة أو cycle في اليوم
+
+253
+00:22:32,920 --> 00:22:37,720
+بيكون عنده اللي هو أربعة آلاف و متين في أربعة و
+
+254
+00:22:37,720 --> 00:22:45,640
+عشرين أربعة آلاف و متين في
+
+255
+00:22:45,640 --> 00:22:51,220
+أربعة و عشرين بيطلع
+
+256
+00:22:51,220 --> 00:22:59,760
+مية و تسعة و سبعين ألف و متين ضربة هذا في اليوم في
+
+257
+00:22:59,760 --> 00:23:00,260
+السنة
+
+258
+00:23:03,930 --> 00:23:08,510
+هتكون عند مية و تسعة و سبعين ألف و متين في تلت مية
+
+259
+00:23:08,510 --> 00:23:13,410
+و خمس و ستين يوم في
+
+260
+00:23:13,410 --> 00:23:21,790
+تلت مية و خمس و ستين بيطلع خمسة
+
+261
+00:23:21,790 --> 00:23:28,490
+و ستين مليون اربعمية و تمانية الف سايكل هذه في سنة
+
+262
+00:23:31,510 --> 00:23:37,150
+لو بدى يعيشله سبعين سنة في سبعين سنة مثلا متوسط
+
+263
+00:23:37,150 --> 00:23:44,370
+العمارة تقريبا سبعين سنة هيكون خمسة ستين مليون
+
+264
+00:23:44,370 --> 00:23:49,770
+واربعمية او تمانية الف في سبعين
+
+265
+00:24:01,170 --> 00:24:04,490
+ضلت في واحد ساعة مش مشكلة بطلع تقريبا .. خليني أحط
+
+266
+00:24:04,490 --> 00:24:10,630
+صفار .. سفر .. سفر .. سفر .. هاي .. تمانية .. ستة
+
+267
+00:24:10,630 --> 00:24:19,570
+.. تسعة ..تمانى ستة تسعة تلاتة أربعة ستة فاصلة
+
+268
+00:24:19,570 --> 00:24:26,370
+أربعة يعني لشخص .. نحكي أكتر من دهان تلاتة ستة
+
+269
+00:24:26,370 --> 00:24:35,520
+تسعة يعني تقريبا تحكي حوالي خمسة مليار ضربةلشخص
+
+270
+00:24:35,520 --> 00:24:38,520
+بيعيش حياة طبيعية في حدود سبعين و واحد و سبعين سنة
+
+271
+00:24:38,520 --> 00:24:44,400
+بدرب لحوالي خمس مليون .. خمس مليار cycle يعني أكم
+
+272
+00:24:44,400 --> 00:24:52,280
+عشرة يعني خمسة في عشرة plus تسعة فتخيلوا أيش ال
+
+273
+00:24:52,280 --> 00:24:56,620
+fatigue loading اللي موجود على عضلة .. عضلة القلب
+
+274
+00:25:00,960 --> 00:25:05,360
+معناته ال fatigue loading موجود معناته عضلة القلب
+
+275
+00:25:05,360 --> 00:25:10,200
+لازم يكون لها مواصفات تتحمل ال cycles هذه لحد ما
+
+276
+00:25:10,200 --> 00:25:13,440
+يصير .. مايصير failure، مايصير فيها ضعف أو يصير
+
+277
+00:25:13,440 --> 00:25:20,970
+عنده تصلب او اي مشكلة تانيةطيب، انا في عند حكيت
+
+278
+00:25:20,970 --> 00:25:23,470
+عندي low cycle fatigue إذا كان number of cycles to
+
+279
+00:25:23,470 --> 00:25:25,930
+failure أقل من ألف وعندي high cycle fatigue إذا
+
+280
+00:25:25,930 --> 00:25:28,330
+كان ال cycles to failure أكتر من ألف، في عندي
+
+281
+00:25:28,330 --> 00:25:32,190
+finite life fatigue إذا كان ال cycles to .. إذا
+
+282
+00:25:32,190 --> 00:25:35,930
+كان ال life .. ال cycles to .. to failure أقل من
+
+283
+00:25:35,930 --> 00:25:39,610
+.. من مليون، إذا أكبر مليون بيكون عندي infinite
+
+284
+00:25:39,610 --> 00:25:43,550
+life، اللحظة في عندي stress level هنا، بسميه
+
+285
+00:25:43,550 --> 00:25:45,050
+stress level
+
+286
+00:25:47,780 --> 00:25:54,000
+بسميه SE SE هذه هي ال endurance limit ال endurance
+
+287
+00:25:54,000 --> 00:26:00,940
+limit هي ال stress level below which the specimen
+
+288
+00:26:00,940 --> 00:26:04,760
+will not fail يعني هو ال stress level اللي تحته
+
+289
+00:26:04,760 --> 00:26:09,000
+العينة و العمر هتنكسر هتظل عايشة لما لإنهاية
+
+290
+00:26:09,000 --> 00:26:13,120
+معناته if we apply a stress level below the
+
+291
+00:26:13,120 --> 00:26:18,170
+endurance limit the specimen will not failمعناته
+
+292
+00:26:18,170 --> 00:26:23,990
+definition ال endurance limit ال S E هي ال stress
+
+293
+00:26:23,990 --> 00:26:29,130
+level below which the specimen will not fail
+
+294
+00:26:29,130 --> 00:26:36,010
+معناته it will endure، endure هيعيش لماله نهاية
+
+295
+00:26:36,010 --> 00:26:42,050
+هذا
+
+296
+00:26:42,050 --> 00:26:48,520
+طبعا الشكل اللي شفناه في حالةاللي هو السبائك
+
+297
+00:26:48,520 --> 00:26:52,580
+الحديد لكن في حال اللي هي السبائك الغير حددية اللي
+
+298
+00:26:52,580 --> 00:26:59,140
+هي nonferrous metals it does not show endurance
+
+299
+00:26:59,140 --> 00:27:05,840
+limit هيكون
+
+300
+00:27:05,840 --> 00:27:10,080
+الاس ان دايران بالشكل هذا يعني بيبقوا نازل على طول
+
+301
+00:27:10,080 --> 00:27:16,830
+مافيش بصالش انه بيصير flatفي الحالة هذه I define
+
+302
+00:27:16,830 --> 00:27:20,990
+fatigue strength for a specified number of cycles
+
+303
+00:27:20,990 --> 00:27:25,370
+يعني إذا كان ال .. ال .. for a stress level مائة
+
+304
+00:27:25,370 --> 00:27:30,590
+ميجا هيعيش مليون for a stress level متين ميجا
+
+305
+00:27:30,590 --> 00:27:36,490
+هيعيش ل متين ألف cycle يعني ال life أو عمر القطة
+
+306
+00:27:36,490 --> 00:27:40,170
+مرتبطة بال stress level كل ما زاد ال stress level
+
+307
+00:27:40,170 --> 00:27:42,290
+كل ما عمر القطة كان أقل
+
+308
+00:27:50,240 --> 00:27:55,760
+معناه تلخص في ال stress life method انا باخد عينة
+
+309
+00:27:55,760 --> 00:28:01,360
+من المادة عينة ميارية بعمل tensile test بارسم ال S
+
+310
+00:28:01,360 --> 00:28:08,440
+-N diagram و بعرف ال number of cycles to failure
+
+311
+00:28:10,870 --> 00:28:15,470
+depending على ال loading أو قيمة التحميل على القطع
+
+312
+00:28:15,470 --> 00:28:18,830
+الميكانيكية الطريقة التانية هي ال strain life
+
+313
+00:28:18,830 --> 00:28:21,510
+method ال strain life method في ال strain life
+
+314
+00:28:21,510 --> 00:28:24,870
+method بعمل detailed analysis of the plastic
+
+315
+00:28:24,870 --> 00:28:28,650
+deformation at localized regions الآن في ال strain
+
+316
+00:28:28,650 --> 00:28:32,290
+life method بقدرس اللي هو ال deformations اللي
+
+317
+00:28:32,290 --> 00:28:38,670
+بيصير locally عند نقاط معينة في القطع الميكانيكية
+
+318
+00:28:42,060 --> 00:28:47,020
+عادة الفتيك فيلير ببدأ at a local discontinuity
+
+319
+00:28:47,020 --> 00:28:52,220
+يعني إذا عندي sudden change إذا عندي هاي شافت و
+
+320
+00:28:52,220 --> 00:28:57,540
+القطر بتاعه إيش مصدر هنا
+
+321
+00:28:57,540 --> 00:29:03,380
+ممكن يصير عندي الآن أدخل local يعني نقطة هنا أدخل
+
+322
+00:29:03,380 --> 00:29:04,340
+ال plastic range
+
+323
+00:29:09,530 --> 00:29:11,970
+لما ادخلت ال plastic range بيصير عندى plastic
+
+324
+00:29:11,970 --> 00:29:15,730
+deformation لوكالي و شوي شوي بتبدأ تصير عندى تشقق
+
+325
+00:29:15,730 --> 00:29:18,870
+التشقق بيكبر شوي شوي شوي شوي لحد ما يصير عندى
+
+326
+00:29:18,870 --> 00:29:23,030
+sudden failure يعني وين في عندى اللي هو local
+
+327
+00:29:23,030 --> 00:29:26,050
+discontinuity عندى stress concentration او حالة
+
+328
+00:29:26,050 --> 00:29:34,050
+تانية عند هذه القطعة و فيها ثقب ممكن تصير failure
+
+329
+00:29:34,050 --> 00:29:37,830
+عند النقطة هذه عند .. عند الثقب هنا عندى stress
+
+330
+00:29:43,810 --> 00:29:49,470
+concentration يعني وين في عندى اللى هو تغير مفاجئ
+
+331
+00:29:49,470 --> 00:29:51,370
+فى ال cross section بيكون عندى stress
+
+332
+00:29:51,370 --> 00:29:54,910
+concentration بيصير locally .. local يعني ده نقطة
+
+333
+00:29:54,910 --> 00:29:59,670
+هدى ال stress level ممكن ادخل ال plastic range
+
+334
+00:29:59,670 --> 00:30:03,290
+دخلت ال plastic range بتبدأ تشقق صار تشقق و التشقق
+
+335
+00:30:03,290 --> 00:30:05,970
+بيصير اكبر شوية شوية لحد ما يصير عندى صدر انفريال
+
+336
+00:30:19,910 --> 00:30:25,230
+طيب الان عند discontinuity يعني مثلا عندي .. عندي
+
+337
+00:30:25,230 --> 00:30:33,990
+fillet او عندي ثقب و روحت رسمت ال stress مع ال
+
+338
+00:30:33,990 --> 00:30:38,990
+strain الان بدأ اللغة تزيد شوي شوي لحد ما locally
+
+339
+00:30:41,890 --> 00:30:47,090
+ال stress بزيد شوية شوية لحد ما locally هاد ال
+
+340
+00:30:47,090 --> 00:30:52,130
+first reversal دخلت في ال plastic range طبعا دي
+
+341
+00:30:52,130 --> 00:30:57,950
+قطع بتدور تتحرك تتحرك معناته بيبدأ ال loading يعكس
+
+342
+00:30:57,950 --> 00:31:00,990
+هيبدأ ال stress level ينزل
+
+343
+00:31:13,290 --> 00:31:16,790
+بيصير بالعكس عندى هى ال second هى ال first هى
+
+344
+00:31:16,790 --> 00:31:20,750
+الرقم واحد هاد ال second reverse صارت stress
+
+345
+00:31:20,750 --> 00:31:24,570
+بالاتجاه المعاكس مثلا هنا هى كانت ال tension صار
+
+346
+00:31:24,570 --> 00:31:29,250
+ايش compression ودخلت برضه ل plastic range لان
+
+347
+00:31:29,250 --> 00:31:34,570
+استمر القطع و الشات في الدوران هيبدأ ال stress
+
+348
+00:31:34,570 --> 00:31:41,990
+يزيد يزيد يزيد لحد ما يسفر بعدين هيبدأ يرفع تانى
+
+349
+00:31:47,530 --> 00:31:54,570
+هذه الـ third reversal صار بالموجب القطع
+
+350
+00:31:54,570 --> 00:32:00,110
+الميكانيكية بتلف هيبدأ
+
+351
+00:32:00,110 --> 00:32:04,810
+تلف يبدأ ال stress level بقل بقل بقل بعدين بيصير
+
+352
+00:32:04,810 --> 00:32:07,630
+يزيد باتجاه المعاكس مثلا هنا كان tension بيبدأ
+
+353
+00:32:07,630 --> 00:32:11,150
+يدخل في ال compression compression compression لحد
+
+354
+00:32:11,150 --> 00:32:13,370
+ما بدأ يدخل ال plastic range لأن بدأ يدخل ال
+
+355
+00:32:13,370 --> 00:32:19,740
+plastic rangeلحد موصلنا هنا هاي الرابع لحظة كل
+
+356
+00:32:19,740 --> 00:32:24,160
+مالها ال strength للقطع الميكانيكية كل مالها بتقل
+
+357
+00:32:24,160 --> 00:32:31,660
+الان بلف ال shaft بيصير ال stress ال negative
+
+358
+00:32:31,660 --> 00:32:33,640
+stress او ال compression stress بتتقل شوية شوية
+
+359
+00:32:33,640 --> 00:32:38,360
+شوية لحد ما يصير zero بعدين بيصير يتحول لإيش بدخل
+
+360
+00:32:38,360 --> 00:32:42,380
+على ال tension بزيد بزيد لحد دخلت ال plastic range
+
+361
+00:32:45,710 --> 00:32:51,450
+هاي الخامسة هي اللي كانت إيش الرابعة لحظة كل ما
+
+362
+00:32:51,450 --> 00:32:56,910
+لها ال strength بتقل لو قررت هتصير أشي زي هيك عنده
+
+363
+00:32:56,910 --> 00:33:03,290
+هذه
+
+364
+00:33:03,290 --> 00:33:12,970
+السادسة سبعة
+
+365
+00:33:15,250 --> 00:33:20,790
+كلما الاسترنك تشبع لها بتقل التام نوعها كذا لحد ما
+
+366
+00:33:20,790 --> 00:33:25,270
+يصير عندى sudden failure واضح ان ال stress is
+
+367
+00:33:25,270 --> 00:33:28,370
+cycling between tension and compression tension
+
+368
+00:33:28,370 --> 00:33:30,310
+and compression يعني في عندى completely reversed
+
+369
+00:33:30,310 --> 00:33:36,730
+.. completely reversed cycling بين طبعا انا في كل
+
+370
+00:33:36,730 --> 00:33:40,280
+حوالlocally بدخل ال .. هنا دخلت ال plastic range
+
+371
+00:33:40,280 --> 00:33:42,320
+وهنا دخلت ال plastic range بس هنا دخلت ال plastic
+
+372
+00:33:42,320 --> 00:33:46,540
+range while tension بيكون مجدود هنا دخلت ال
+
+373
+00:33:46,540 --> 00:33:49,860
+plastic range while compression يعني هنا ال
+
+374
+00:33:49,860 --> 00:33:56,200
+plastic tension هنا ال plastic compression طبعا
+
+375
+00:33:56,200 --> 00:34:02,740
+القطع بتضعفأو بـ Serial Crack Propagation لحد ما
+
+376
+00:34:02,740 --> 00:34:06,360
+الـ cross section يقل و يصبح لديه sudden failure
+
+377
+00:34:06,360 --> 00:34:15,160
+طبعا في كل الأحوال هذا هو الـ total strain هذا
+
+378
+00:34:15,160 --> 00:34:20,180
+دلتا أبسلون دلتا أبسلون جزئين هناخدها هنا من برا
+
+379
+00:35:05,490 --> 00:35:16,870
+خلنا نستخدم لونان هذا
+
+380
+00:35:16,870 --> 00:35:16,910
+هتكون
+
+381
+00:35:32,950 --> 00:35:41,030
+الـ delta epsilon elastic على اتنين وهذا الـ delta
+
+382
+00:35:41,030 --> 00:35:51,670
+epsilon plastic على اتنين وهنا بالعكس الـ
+
+383
+00:35:51,670 --> 00:35:55,030
+delta epsilon elastic على اتنين وهذا الـ delta
+
+384
+00:35:55,030 --> 00:35:57,010
+epsilon plastic على اتنين
+
+385
+00:36:03,860 --> 00:36:10,400
+delta epsilon على اتنين بالموجب وهنا هتكون delta
+
+386
+00:36:10,400 --> 00:36:18,200
+epsilon على اتنين فواضح فيه ان انا ممكن اسمي ال
+
+387
+00:36:18,200 --> 00:36:21,940
+delta epsilon على اتنين هي ال total strain
+
+388
+00:36:21,940 --> 00:36:27,520
+amplitude لان ال strain يعني بتتغير بالشكل هذا ال
+
+389
+00:36:27,520 --> 00:36:27,860
+strain
+
+390
+00:36:31,200 --> 00:36:36,460
+فهذا الـ strain الـ strain amplitude الـ strain
+
+391
+00:36:36,460 --> 00:36:41,640
+amplitude مكوّم
+
+392
+00:36:41,640 --> 00:36:45,360
+جزئين اللي هو reversible strain اللي هو الـ
+
+393
+00:36:45,360 --> 00:36:50,320
+elastic strain دلتا أبسرن إلاستك على اتنين زائد
+
+394
+00:36:50,320 --> 00:36:53,620
+اللي هو ال permanent اللي هي ال plastic دلتا أبسرن
+
+395
+00:36:53,620 --> 00:36:56,300
+plastic على اتنين
+
+396
+00:37:12,630 --> 00:37:18,950
+الان بيضالوا ال strain انا من cycles of strain لحد
+
+397
+00:37:18,950 --> 00:37:23,690
+ما يصير failure لحد ما يصير failure اذا عملت plot
+
+398
+00:37:23,690 --> 00:37:28,910
+اذا عملت plot على log log scale يعني هنا عندي ال
+
+399
+00:37:28,910 --> 00:37:34,530
+reversals to failure انا و هنا عندي ال strain
+
+400
+00:37:34,530 --> 00:37:35,510
+amplitude
+
+401
+00:37:37,540 --> 00:37:40,780
+strain amplitude طبعا احنا حكينا ال strain
+
+402
+00:37:40,780 --> 00:37:44,660
+amplitude مكوّن من elastic part و plastic part هذا
+
+403
+00:37:44,660 --> 00:37:54,060
+الجزء اللي
+
+404
+00:37:54,060 --> 00:38:01,540
+هو delta elastic على اتنين هذا الجزء
+
+405
+00:38:09,180 --> 00:38:14,380
+اللي هو delta epsilon plastic على اتنين وال curve
+
+406
+00:38:14,380 --> 00:38:21,560
+هذا هذا
+
+407
+00:38:21,560 --> 00:38:26,340
+هو ال total delta
+
+408
+00:38:26,340 --> 00:38:33,020
+ال epsilon على اتنين total strain amplitude هنا
+
+409
+00:38:33,020 --> 00:38:39,080
+عندي عشر او اثنان اقصى اربعةعشر أقص ناقص ثلاثة عشر
+
+410
+00:38:39,080 --> 00:38:44,020
+أقص ناقص اتنين عشر أقص ناقص واحد عشر أقص سفر هي
+
+411
+00:38:44,020 --> 00:38:46,660
+عشر أقص سفر عشر أقص واحد عشر أقص اتنين عشر أقص
+
+412
+00:38:46,660 --> 00:38:51,680
+تلاتة عشر أقص أربعة عشر أقص خمسة عشر أقص ستة لأن
+
+413
+00:38:51,680 --> 00:38:55,220
+لاحظوا delta absolute elastic على اتنين بالساوية
+
+414
+00:38:55,220 --> 00:38:57,620
+ال elastic external amplitude زي ال plastic
+
+415
+00:38:57,620 --> 00:39:00,160
+external amplitude لكن انا عندي هاي هذا elastic
+
+416
+00:39:00,160 --> 00:39:04,230
+external amplitude وهي plastic external amplitudeو
+
+417
+00:39:04,230 --> 00:39:08,850
+ال total strain مجموهم لأن ممكن البعض يعتقد ان هذا
+
+418
+00:39:08,850 --> 00:39:11,030
+ال curve مش صح المفروض يعمله shift لعله لأ هذا
+
+419
+00:39:11,030 --> 00:39:14,170
+صحيح بس تذكروا انا على الجهة ايه برسم على log
+
+420
+00:39:14,170 --> 00:39:16,470
+scale برسم على log scale
+
+421
+00:39:21,500 --> 00:39:27,760
+طيب الآن ال slope هذا في slope لل ال elastic
+
+422
+00:39:27,760 --> 00:39:31,840
+strain amplitude يسمى B وفي slope لل plastic
+
+423
+00:39:31,840 --> 00:39:36,640
+strain amplitude اللي هو C وفي عند النقطة هذه
+
+424
+00:39:36,640 --> 00:39:42,620
+epsilon F في ال prime وهنا عندي sigma F في ال
+
+425
+00:39:42,620 --> 00:39:58,190
+prime على E هذا ايشالـ slope هذا ايش يمثل ايه
+
+426
+00:39:58,190 --> 00:40:05,890
+هذا
+
+427
+00:40:05,890 --> 00:40:11,570
+برضه ايه وهي اللي عندي هنا delta epsilon elastic
+
+428
+00:40:11,570 --> 00:40:17,970
+على اتنين وهذه هتكون سيجما
+
+429
+00:40:21,260 --> 00:40:27,900
+أف في الـ prime و هذه
+
+430
+00:40:27,900 --> 00:40:31,360
+النقطة بالذات اللي هي أبسلون أف في ال prime
+
+431
+00:40:31,360 --> 00:40:37,580
+الأبسلون
+
+432
+00:40:37,580 --> 00:40:40,420
+أف في ال prime هي ال true strain at which fracture
+
+433
+00:40:40,420 --> 00:40:45,800
+occurs in one reversal الأبسلون
+
+434
+00:40:45,800 --> 00:40:49,730
+أف في ال prime هي قيمة ال strainاللي بيصير عندها
+
+435
+00:40:49,730 --> 00:40:52,210
+failure من أول reversal لحد ما يصل لهذه من
+
+436
+00:40:52,210 --> 00:40:56,290
+reversal رقم واحد بيصير كسر هي هذه أبسلون F الـ
+
+437
+00:40:56,290 --> 00:41:03,470
+Prime وال Sigma F Prime هي ال stress level اللي
+
+438
+00:41:03,470 --> 00:41:06,930
+بيصير عندها كسر من أول reversal، يعني النقطة هذه،
+
+439
+00:41:06,930 --> 00:41:14,450
+هذه Sigma F Prime والـ
+
+440
+00:41:14,450 --> 00:41:20,100
+Bالـ slope للـ elastic strain والـ C ال slope لل
+
+441
+00:41:20,100 --> 00:41:25,240
+.. ال B ال slope لل elastic strain curve والـ C ال
+
+442
+00:41:25,240 --> 00:41:33,440
+slope لل plastic strain curve الآن
+
+443
+00:42:00,580 --> 00:42:08,060
+لاحظوا ال .. ال .. عندي ال slope للإيلاس B بي اللي
+
+444
+00:42:08,060 --> 00:42:18,220
+هي ال slope of ال elastic strain line وال
+
+445
+00:42:18,220 --> 00:42:26,740
+C هي ال slope of plastic strain line
+
+446
+00:42:30,130 --> 00:42:33,910
+و هدا ال intercept اللي هي epsilon F prime و هدا
+
+447
+00:42:33,910 --> 00:42:43,110
+sigma F prime على E معناته واضح ان العلاقة على log
+
+448
+00:42:43,110 --> 00:42:50,410
+log scale is linear و العلاقة لل elastic لل
+
+449
+00:42:50,410 --> 00:42:54,330
+plastic strain line is linear لل elastic strain
+
+450
+00:42:54,330 --> 00:42:59,340
+line is linear معناته ممكن اعبر على العلاقة بينالـ
+
+451
+00:42:59,340 --> 00:43:03,360
+strain amplitude و ال number of cycles او ال
+
+452
+00:43:03,360 --> 00:43:07,760
+reversals to failure as a power law يعني بدكن احكي
+
+453
+00:43:07,760 --> 00:43:15,380
+delta epsilon plastic على 2 هتكون epsilon f prime
+
+454
+00:43:16,000 --> 00:43:21,600
+فى اتنين N قصى C و ال Delta Epsilon Elastic على
+
+455
+00:43:21,600 --> 00:43:28,080
+اتنين هتكون اللى هى Sigma F Prime على E فى اتنين N
+
+456
+00:43:28,080 --> 00:43:28,980
+قصى B
+
+457
+00:43:38,390 --> 00:43:41,570
+لو أخدت ال log للطرفين هتطلع علاقة إيش linear
+
+458
+00:43:41,570 --> 00:43:46,770
+هتطلع linear بين ال log دلت أبسترون مع ال cycle ال
+
+459
+00:43:46,770 --> 00:44:01,010
+number of reversals طيب
+
+460
+00:44:11,570 --> 00:44:14,750
+الـ Total Strain Amplitude اللي هي Delta Epsilon
+
+461
+00:44:14,750 --> 00:44:20,250
+على 2 هتكون مجموع الـ Elastic Strain Amplitude مع
+
+462
+00:44:20,250 --> 00:44:24,930
+الـ Plastic Strain Amplitude و هنعوض عند الـ
+
+463
+00:44:24,930 --> 00:44:31,690
+Elastic اللي هي Sigma F Prime على E في 2N أُس B
+
+464
+00:44:31,690 --> 00:44:38,710
+زائد اللي هي Epsilon F Prime في 2N أُس C
+
+465
+00:44:48,810 --> 00:44:54,790
+طيب في الكتاب روحوا appendix A23
+
+466
+00:44:56,720 --> 00:45:01,680
+بيعطيني values of coefficients اللي هي بي بي اللي
+
+467
+00:45:01,680 --> 00:45:09,000
+هو appendix a تلاتة و عشرين في كتاب شغلي بيعطيني
+
+468
+00:45:09,000 --> 00:45:17,900
+اللي هو بي او سي و أبسلن اف برايم او سيجما اف
+
+469
+00:45:17,900 --> 00:45:26,520
+برايم خلنا نشوف هنا ال table نتأكد
+
+470
+00:45:38,710 --> 00:45:41,850
+هذا table A23 زي ما انتوا شايفين ال headings
+
+471
+00:45:41,850 --> 00:45:46,090
+اتطلعوا على أقصى يمين ال table عند ال fatigue
+
+472
+00:45:46,090 --> 00:45:50,770
+strength exponent B موجود و ال fatigue ductility
+
+473
+00:45:50,770 --> 00:45:55,250
+exponent C موجود و ال fatigue ductility
+
+474
+00:45:55,250 --> 00:45:59,290
+coefficient F prime موجوديعني عندها هي sigma f
+
+475
+00:45:59,290 --> 00:46:04,450
+prime و ال b و ال epsilon f prime و ال c لسبائك
+
+476
+00:46:04,450 --> 00:46:08,550
+مختلفة من سبائك الحديد يعني هنا عند العملي الأول
+
+477
+00:46:08,550 --> 00:46:14,690
+ليه رقم سبكة الحديد و ال description تاعة ومعطية
+
+478
+00:46:14,690 --> 00:46:17,810
+ال hardness تنصفها ال strength و ال ductility in
+
+479
+00:46:17,810 --> 00:46:22,110
+terms of reduction in areaو ال true strain at
+
+480
+00:46:22,110 --> 00:46:25,730
+fracture اللي بيمثل برضه التعبير عن ال ductility و
+
+481
+00:46:25,730 --> 00:46:30,250
+ال modulus و ال STE و ال sigma F prime و ال B و S
+
+482
+00:46:30,250 --> 00:46:34,830
+F prime و C هذا كله موجود في تابل A23 for
+
+483
+00:46:34,830 --> 00:46:41,350
+different alloys of steelالان ال equation هذه اللي
+
+484
+00:46:41,350 --> 00:46:45,270
+انتوا شايفينها دلتا أبسطران على اتنين بيساو
+
+485
+00:46:45,270 --> 00:46:47,990
+سيجنافه برايم على E في اتنين أنوس P زي اتنين
+
+486
+00:46:47,990 --> 00:46:52,270
+أبسطران على اتنين أنوس C has limited use in design
+
+487
+00:46:52,270 --> 00:46:56,730
+لأنه ببساطة قيم ال total strain عندي ال
+
+488
+00:46:56,730 --> 00:47:01,510
+discontinuity الصعب انك مش موجودة المعلومات هذه و
+
+489
+00:47:01,510 --> 00:47:08,850
+صعب قياسها و حسابها انا معناته هنشوفنفكر بطريقة
+
+490
+00:47:08,850 --> 00:47:13,590
+تانية فاكرين
+
+491
+00:47:13,590 --> 00:47:23,950
+ال S-and diagram او احنا الان اخد اللي صار اخده
+
+492
+00:47:23,950 --> 00:47:30,060
+different materials مثلا دي material واحدmaterial
+
+493
+00:47:30,060 --> 00:47:34,140
+اتنين material تلاتة طبعا سباق للحدد للحديد
+
+494
+00:47:34,140 --> 00:47:40,000
+material اربع material خمسة و .. و انا بعرف ال
+
+495
+00:47:40,000 --> 00:47:42,860
+tensile strength ل material واحد و اتنين و تلاتة و
+
+496
+00:47:42,860 --> 00:47:47,900
+اربع و خمسة و بعرف ال endurance limit للعينات
+
+497
+00:47:47,900 --> 00:47:57,000
+معيارية SE prime الآن عملنا plot بينالـ S A' و الـ
+
+498
+00:47:57,000 --> 00:48:01,620
+S U T يعني هنا عندي على المحور الأفقي S U T وعندي
+
+499
+00:48:01,620 --> 00:48:08,780
+هنا S A' اتطلع على ال trend بتاع البيانات كيف
+
+500
+00:48:08,780 --> 00:48:15,220
+البيانات بتتصرف لاحظوا تقريبا في علاقة خطية بعدين
+
+501
+00:48:15,220 --> 00:48:18,820
+بيصير ثابتة يعني لاحظوا البيانات كيف هذه
+
+502
+00:48:18,820 --> 00:48:24,750
+experimental dataعندي تقريبا في تغير خط بين ال SE
+
+503
+00:48:24,750 --> 00:48:30,030
+prime لحد ال ultimate strength معين بعدين بيبدأ
+
+504
+00:48:30,030 --> 00:48:35,900
+يصير ash بتثبت قيمة ال SE primeلاحظوا عندى تلت
+
+505
+00:48:35,900 --> 00:48:40,840
+خطوط عند خط فى النص وخط اعلى خط فى النص مكتوب عليه
+
+506
+00:48:40,840 --> 00:48:45,620
+point five وخط فى النص اللى هو SE على SE prime على
+
+507
+00:48:45,620 --> 00:48:49,440
+SE بالساوية point five وهنا عندى SE prime على SA
+
+508
+00:48:49,440 --> 00:48:53,900
+اللى هي point six وهنا عندى SE prime على SU
+
+509
+00:48:53,900 --> 00:49:01,120
+بالساوية point أربعة الخط اللى فى النص بيبثله
+
+510
+00:49:02,770 --> 00:49:07,950
+خمسين في المية reliability للبيانات خمسين في المية
+
+511
+00:49:07,950 --> 00:49:11,370
+reliability لل data يعني ايش يعني خمسين في المية؟
+
+512
+00:49:11,370 --> 00:49:18,290
+معناته experimentally او هذا الخط بيمثل ان هذا جهة
+
+513
+00:49:18,290 --> 00:49:22,930
+واقع في النص ممكن تكون القيم الحقيقية احتمال تكون
+
+514
+00:49:22,930 --> 00:49:25,750
+خمسين في المية اعلى او اقل خمسين في المية اعلى او
+
+515
+00:49:25,750 --> 00:49:34,790
+اقلالـ curve fitting بين الـ SE prime و ال SUT for
+
+516
+00:49:34,790 --> 00:49:40,030
+50% reliability of data بيعطينا علاقة هذه SE prime
+
+517
+00:49:40,030 --> 00:49:44,330
+بيستوى نص SUT إذا كانت SUT أقل من 200 kilo pound
+
+518
+00:49:44,330 --> 00:49:48,450
+per square inch و بتستوى 100 kilo pound per square
+
+519
+00:49:48,450 --> 00:49:51,130
+inch إذا كانت SUT أكبر من 200 kilo pound per
+
+520
+00:49:51,130 --> 00:49:55,430
+square inch نرجع تاني لل curve عندنا هيها تقريبا
+
+521
+00:49:58,250 --> 00:50:05,350
+يعني تقريبا جاية في حدود اللي عندها المية مية و
+
+522
+00:50:05,350 --> 00:50:09,670
+عشر تقريبا مية و خمسة هذا الخط اللي في النص يعني
+
+523
+00:50:09,670 --> 00:50:16,170
+هنا عند ميتين ميجا لحد ميتين ميجا هاي ميتين ميجا
+
+524
+00:50:16,170 --> 00:50:20,990
+تقريبا
+
+525
+00:50:20,990 --> 00:50:26,250
+هكون علاقة خطية اللي في النص
+
+526
+00:50:30,480 --> 00:50:36,740
+يعني إذا كانت ال S.U.T أقل من 200 كيلو pound per
+
+527
+00:50:36,740 --> 00:50:40,360
+square inch بتكون ال S.E. prime بيستوى نص ال S.U.T
+
+528
+00:50:40,360 --> 00:50:45,660
+إذا كانت ال S.U.T أكبر من 200 بتصير ال S.E. prime
+
+529
+00:50:45,660 --> 00:50:50,200
+بتثبت ال S.E. prime بتثبت معناته في علاقة بين ال
+
+530
+00:50:50,200 --> 00:50:55,330
+tensile strength و ال S.E. primeهي ال endurance
+
+531
+00:50:55,330 --> 00:50:59,770
+limit ل standard tensile specimen standard tensile
+
+532
+00:50:59,770 --> 00:51:03,050
+specimen يعني التجربة انعملت for the case of
+
+533
+00:51:03,050 --> 00:51:12,910
+completely reversed bending loading طيب
+
+534
+00:51:12,910 --> 00:51:13,030
+for design
+
+535
+00:51:25,000 --> 00:51:28,340
+an approximation of the idealized S-N diagram is
+
+536
+00:51:28,340 --> 00:51:35,780
+needed لحسابات التصميم محتاجين نعمل تقريب لل ideal
+
+537
+00:51:35,780 --> 00:51:42,680
+S-N diagram عشان
+
+538
+00:51:42,680 --> 00:51:50,040
+ت estimate fatigue
+
+539
+00:51:50,040 --> 00:51:53,900
+strength عند عشر أو استلاتة نرجع لل S-N diagram
+
+540
+00:51:59,760 --> 00:52:09,380
+هذا الاس اندراجرام هرسمه هنا برا اللي حقله هنا
+
+541
+00:52:09,380 --> 00:52:16,120
+عندي عدد سايكلز عشرة أس تلاتة وهنا عشرة أس ستة
+
+542
+00:52:16,120 --> 00:52:23,860
+وهنا هتكون عندي S U T وهنا عشرة أس صفر يعني واحد
+
+543
+00:52:28,590 --> 00:52:31,790
+لاحظوا ال care ممكن انا اقسمه ل 3 مناطق عند
+
+544
+00:52:31,790 --> 00:52:37,330
+المنطقة هذه العلاقة خطية سفق بين واحد و ألف و بين
+
+545
+00:52:37,330 --> 00:52:42,250
+ألف و مليون برضه علاقة خطية بس بسلوب مختلف الآن
+
+546
+00:52:42,250 --> 00:52:47,890
+هنتبع
+
+547
+00:52:47,890 --> 00:52:52,230
+مع بعضالان احنا حكينا ال total strain amplitude
+
+548
+00:52:52,230 --> 00:52:55,970
+مكون من جزئين elastic strain amplitude و plastic
+
+549
+00:52:55,970 --> 00:52:59,830
+strain amplitude ال elastic strain amplitude delta
+
+550
+00:52:59,830 --> 00:53:05,970
+epsilon elastic على اتنين بالساوية sigma f prime
+
+551
+00:53:05,970 --> 00:53:12,610
+على a السابق ان حكينا في اتنين ان اص بي
+
+552
+00:53:19,630 --> 00:53:23,450
+define specimen fatigue strength at a specified
+
+553
+00:53:23,450 --> 00:53:36,710
+number of cycles يعني هين هذا هسميها SF SF'
+
+554
+00:53:38,290 --> 00:53:41,990
+N و هذه ايش N
+
+555
+00:53:43,330 --> 00:53:48,090
+for a specified number of cycle او for a given
+
+556
+00:53:48,090 --> 00:53:52,910
+stress amplitude sf n prime هيعيش n cycles فهيكون
+
+557
+00:53:52,910 --> 00:53:56,570
+ال sf prime
+
+558
+00:53:56,570 --> 00:54:04,330
+n بالسوء E في delta epsilon elastic على اتنين من
+
+559
+00:54:04,330 --> 00:54:09,250
+اين اجت هذه؟ اجت هذه من هنا اذا انا دخلت ال
+
+560
+00:54:09,250 --> 00:54:10,110
+plastic range
+
+561
+00:54:13,310 --> 00:54:20,890
+و نزلت عملت unloading هذا بيظهر عنده اللي هو ال
+
+562
+00:54:20,890 --> 00:54:26,570
+delta epsilon plastic على اتنين وهذا
+
+563
+00:54:26,570 --> 00:54:33,410
+ال delta epsilon elastic على اتنين وهذا عاش ال
+
+564
+00:54:33,410 --> 00:54:43,960
+slope sigma وهذاسوف تكون أسف في الـ prime فهذا
+
+565
+00:54:43,960 --> 00:54:50,740
+ايه يا عزيزي؟ هذا موضلة في ال city هذا خط ال slope
+
+566
+00:54:50,740 --> 00:55:00,140
+بتاعه ايه؟ يعني خط المثلث هذا ستكون
+
+567
+00:55:00,140 --> 00:55:06,030
+ال slope is ايه؟ يعني ستكون أسف في ال primeهتكون
+
+568
+00:55:06,030 --> 00:55:10,090
+سواء E في delta epsilon elastic على 2 من هنا جاءت
+
+569
+00:55:10,090 --> 00:55:15,530
+العلاقة هذه اللي
+
+570
+00:55:15,530 --> 00:55:21,990
+هنحاوض هتكون سواء E في ال delta epsilon elastic
+
+571
+00:55:21,990 --> 00:55:29,550
+على 2 اللي هي هذه sigma F prime على E في 2N plus B
+
+572
+00:55:29,550 --> 00:55:38,100
+هتروح E مع E هتصفي السواء sigma F prime في 2NSB
+
+573
+00:55:38,100 --> 00:55:41,840
+الهي ال fatigue strength for a specified number of
+
+574
+00:55:41,840 --> 00:55:44,140
+cycles is given by this equal to sigma F prime
+
+575
+00:55:44,140 --> 00:55:51,700
+بيستوى 2N أصبى لو
+
+576
+00:55:51,700 --> 00:55:57,720
+كانت ال N عشر أس تلاتة يعني ألف هتكون ال fatigue
+
+577
+00:55:57,720 --> 00:56:03,200
+strength SF prime لعمر عشر أس تلاتة يعني لعمر ألف
+
+578
+00:56:03,200 --> 00:56:10,220
+cycle هتكون سوى sigma F primeفى اتنين فى عشرة أُس
+
+579
+00:56:10,220 --> 00:56:19,840
+تلاتة أُس بى هذه
+
+580
+00:56:19,840 --> 00:56:23,660
+هتساوي F
+
+581
+00:56:23,660 --> 00:56:26,860
+فى S U T
+
+582
+00:56:37,130 --> 00:56:40,550
+يعني هذا اللي بحكيه لما انا احكي اللي هو ال
+
+583
+00:56:40,550 --> 00:56:44,330
+fatigue strength لألف cycle بسواء sigma في prime
+
+584
+00:56:44,330 --> 00:56:48,720
+في اتنين في عشرة ثلاث في اص بياللي له قيمة معينة
+
+585
+00:56:48,720 --> 00:56:55,140
+أنا مش هعرفها هي عبارة عن some fraction of SUT
+
+586
+00:56:55,140 --> 00:57:00,160
+ممكن تكون يعني point 7 5 SUT ممكن تكون point 8 SUT
+
+587
+00:57:00,160 --> 00:57:03,320
+ممكن تكون point 5 SUT ممكن one point one SUT
+
+588
+00:57:03,320 --> 00:57:07,360
+معناته اللي بحكي أنه بغض النظر على قيمة ال fatigue
+
+589
+00:57:07,360 --> 00:57:10,920
+strength for one thousand cycle it will be some
+
+590
+00:57:10,920 --> 00:57:14,240
+fraction of the tensile strength of the specimen
+
+591
+00:57:15,750 --> 00:57:21,430
+يعني في الحالة هذه ال F هيكون ساوية Sigma F في
+
+592
+00:57:21,430 --> 00:57:27,670
+Prime في اتنين في عشر عقص تلاتة عقص B على S U T
+
+593
+00:57:27,670 --> 00:57:38,390
+طيب
+
+594
+00:57:38,390 --> 00:57:41,550
+ال
+
+595
+00:57:41,550 --> 00:57:47,200
+S A E ال هي Society of Automotive EngineersSociety
+
+596
+00:57:47,200 --> 00:57:49,620
+of Automated Engineers عملت ليه approximation
+
+597
+00:57:49,620 --> 00:57:52,940
+للسيجما اف برايم مواطول علاقة للسيجما اف برايم
+
+598
+00:57:52,940 --> 00:57:55,820
+بسلاوة S في حالة الوحدات الإنجليزية بسلاوة S U T
+
+599
+00:57:55,820 --> 00:58:01,410
+زائد خمسينأو في حالة الوحدات المترية ال sigma في
+
+600
+00:58:01,410 --> 00:58:04,690
+ال prime بيستوى sut زي 345 ميجا بس كده هذه ال
+
+601
+00:58:04,690 --> 00:58:08,310
+equation is given by society of automotive
+
+602
+00:58:08,310 --> 00:58:14,330
+engineer في حالة كانت ال harness brine لل material
+
+603
+00:58:14,330 --> 00:58:16,130
+تحت الدراسة أقل من 500
+
+604
+00:58:30,470 --> 00:58:34,670
+الان ممكن تكون عندى هاي هذى كمان ممكن اي نقطة هذى
+
+605
+00:58:34,670 --> 00:58:45,250
+هذى هذى SFN' هذى N الان عند النقطة هذى عند هذى N
+
+606
+00:58:45,250 --> 00:58:53,890
+NE وهين ال stress level ايش بيكون SE'
+
+607
+00:58:55,540 --> 00:59:01,580
+SE' يعني at the endurance limit at ال endurance
+
+608
+00:59:01,580 --> 00:59:05,500
+limit
+
+609
+00:59:05,500 --> 00:59:16,680
+بتكون دي ال SF' بيستوى SE' و ال N بيستوى NE معناته
+
+610
+00:59:16,680 --> 00:59:21,740
+لما نعوض في هذه المعادلة هذه المعادلة حسينا دي SE'
+
+611
+00:59:25,380 --> 00:59:32,540
+بساوة sigma F prime فى 2N عند ال endurance limit E
+
+612
+00:59:32,540 --> 00:59:40,400
+أُس B لو أخدت log الطرفين هشير عندي log خلّين أقسم
+
+613
+00:59:40,400 --> 00:59:47,300
+الطرفين على sigma F prime هشير عندي SE prime على
+
+614
+00:59:47,300 --> 00:59:53,560
+sigma F prime بساوة 2N E أُس B أخد log الطرفين
+
+615
+00:59:53,560 --> 00:59:59,740
+هشير عندي logالـ S A Prime على الـ Sigma F Prime
+
+616
+00:59:59,740 --> 01:00:07,440
+هتكون ساوية B في Log 2NA
+
+617
+01:00:07,440 --> 01:00:18,640
+معناة B هتكون تساوية Log الـ S A Prime على الـ
+
+618
+01:00:18,640 --> 01:00:26,650
+Sigma F Prime على Logالاتنين and ايه طبعا هنا عامل
+
+619
+01:00:26,650 --> 01:00:31,310
+minus في الكتاب بس انتبهوا هنا عنده مش أنا عامل
+
+620
+01:00:31,310 --> 01:00:34,730
+هنا se prime على sigma f prime هو عامل هنا العكس
+
+621
+01:00:34,730 --> 01:00:38,210
+sigma f prime على se prime اللي هي بيساوي minus
+
+622
+01:00:38,210 --> 01:00:42,650
+minus log sigma se prime على sigma f prime فهذه
+
+623
+01:00:42,650 --> 01:00:46,170
+صحيحة وهذه أش وهذه صحيحة بس انتبهوا هنا عنده se
+
+624
+01:00:46,170 --> 01:00:48,810
+prime على sigma f prime هنا عنده sigma f prime على
+
+625
+01:00:48,810 --> 01:00:54,450
+se prime لأن هنا عنده log scaleمعناته الـ B معطبع
+
+626
+01:00:54,450 --> 01:01:00,670
+الـ equation 612 الصفحة هذه تلخيص الكلام اللي
+
+627
+01:01:00,670 --> 01:01:01,190
+حكيناه
+
+628
+01:01:17,130 --> 01:01:23,250
+SF'n بيسوأ لـSF
+
+629
+01:01:23,250 --> 01:01:28,810
+'n هي الـfatigue strength for a standard fatigue
+
+630
+01:01:28,810 --> 01:01:33,330
+specimen for a given number of cycles and مُعطُب
+
+631
+01:01:33,330 --> 01:01:33,770
+العلاقات
+
+632
+01:01:40,920 --> 01:01:44,500
+الـ F اللي هي هتكون سيجما في الـ prime على S U T
+
+633
+01:01:44,500 --> 01:01:47,800
+في اتنين في عشر عشرة أس تلاتة أس بي والسيجما في
+
+634
+01:01:47,800 --> 01:01:51,500
+الـ prime as given by S Society of Automotive
+
+635
+01:01:51,500 --> 01:01:54,440
+Engineers في معادل ال English unit وفي معادل ال
+
+636
+01:01:54,440 --> 01:01:56,980
+metric unit بالسواء S U T زائد خمسين في حالة ال
+
+637
+01:01:56,980 --> 01:01:59,260
+English unit والسيجما في ال prime بالسواء S U T
+
+638
+01:01:59,260 --> 01:02:01,400
+زائد تلاتمية وخمسة الميجا بس كان في حالة ال metric
+
+639
+01:02:01,400 --> 01:02:08,850
+unit والـ B اللي هي هذهis given by minus log sigma
+
+640
+01:02:08,850 --> 01:02:18,710
+F prime على S A prime على log 2 N A طيب
+
+641
+01:02:18,710 --> 01:02:22,650
+احنا هنعوض في المعادلة هذه sigma F prime بنحسبه من
+
+642
+01:02:22,650 --> 01:02:27,170
+المعادلة هذه و ال B بنحسبه من المعادلة هذه يعني
+
+643
+01:02:27,170 --> 01:02:30,470
+عندي ال sigma F prime من هذه المعادلة و ال B من
+
+644
+01:02:30,470 --> 01:02:33,890
+هذه المعادلة منها بحسب ال S F و S F prime for a
+
+645
+01:02:33,890 --> 01:02:36,050
+specified number of cycles
+
+646
+01:02:44,990 --> 01:02:48,350
+ممكن المعادلة هي دي F بسوة سجما في البرانو على S U
+
+647
+01:02:48,350 --> 01:02:55,150
+T بسوة اتنين في عشر عقل تلاتة اص B هعملها على شكل
+
+648
+01:02:55,150 --> 01:02:59,650
+curve as
+
+649
+01:02:59,650 --> 01:03:02,730
+a function of S U T يعني دي هي ال S U T على المحور
+
+650
+01:03:02,730 --> 01:03:07,410
+الأفقي وعلى المحور الرأسي ايش ال Fو من ال curve
+
+651
+01:03:07,410 --> 01:03:11,890
+هذا اذا انا عارف ال tensile strength بطلع ال .. ال
+
+652
+01:03:11,890 --> 01:03:21,050
+.. ال F اللي هو figure 618 طيب
+
+653
+01:03:21,050 --> 01:03:27,030
+نرجع لل S-undagram كمان مرة ال S-undagram زي اللي
+
+654
+01:03:27,030 --> 01:03:31,730
+انتوا شايفين ممكن يتقسم لتلت مراحل المرحلة اللي
+
+655
+01:03:31,730 --> 01:03:37,300
+لها هي عبارة مرحلة من هنا SUTيعني خلّيني أحط
+
+656
+01:03:37,300 --> 01:03:47,000
+الإحداثيات بتاعة النقاط هذه عبارة عن واحد و S U T
+
+657
+01:03:47,000 --> 01:03:58,000
+وهنا النقطة التانية عبارة عن عشر أقل ثلاثة
+
+658
+01:03:58,000 --> 01:04:05,040
+و S F Prime
+
+659
+01:04:06,860 --> 01:04:19,760
+و هى عندى عشرة أقل ستة و S A prime معناته
+
+660
+01:04:19,760 --> 01:04:25,980
+احنا في حالة finite life fatigue حكينا two
+
+661
+01:04:25,980 --> 01:04:31,930
+equations equation من N equal واحد لألفEquation من
+
+662
+01:04:31,930 --> 01:04:36,630
+un equal الف لحد مليون يعني لأن ميل الخط هذا مختلف
+
+663
+01:04:36,630 --> 01:04:39,510
+عن ميل الخط هذا معناته اندي معدل تاني الخط هذا له
+
+664
+01:04:39,510 --> 01:04:45,690
+معدلة والخط هذا له معدلة نبدأ
+
+665
+01:04:45,690 --> 01:04:51,150
+في المرحلة الأولى اللى هى الان من واحد لألف او او
+
+666
+01:04:51,150 --> 01:04:57,050
+او ناخد التانى اللى من الف لمليون من الف لمليون
+
+667
+01:05:01,610 --> 01:05:09,630
+هنا لما عدد ال cycles ألف هتكون هنا هذه ساوية F S
+
+668
+01:05:09,630 --> 01:05:14,750
+U T وعند عشر أقصى ستة بتكون عشر أقصى ستة و S E
+
+669
+01:05:14,750 --> 01:05:21,870
+Prime يعني هذه النقطة هذه اللي هي عشر أقصى ثلاثة و
+
+670
+01:05:21,870 --> 01:05:30,370
+F S U T و النقطة هذه عبارة عن عشر أقصى ستة و S E
+
+671
+01:05:30,370 --> 01:05:30,670
+Prime
+
+672
+01:05:37,030 --> 01:05:41,690
+هذه على log .. log scale أو على ال .. ال .. على ال
+
+673
+01:05:41,690 --> 01:05:49,630
+semi log scale هتكون الأسقف في الفترة من عشر أُس
+
+674
+01:05:49,630 --> 01:06:00,630
+ثلاثة عشر أُس ستة بالسوء A في N أُس B طيب
+
+675
+01:06:00,630 --> 01:06:08,000
+في عندى نقطتين يعني النقطة الأولى atعشرة أس تلاتة
+
+676
+01:06:08,000 --> 01:06:14,400
+يعني N بالسوية عشرة أس تلاتة ال N بالسوية عشرة أس
+
+677
+01:06:14,400 --> 01:06:22,500
+تلاتة كون أندي ال S F بالسوية F S U T يعني نعوض
+
+678
+01:06:22,500 --> 01:06:34,630
+هنا عندي F S U T بتسوية A في عشرة أس تلاتةاس بي
+
+679
+01:06:34,630 --> 01:06:42,870
+هاي معادلة اياش واحد و at n بالساوية عشرة اقل ستة
+
+680
+01:06:42,870 --> 01:06:48,770
+بتكون الاس اف بالساوية اس اي prime او اس اي كده
+
+681
+01:06:48,770 --> 01:06:53,530
+نسميها اس اي يعني حيكون حنعود ان اس اف باس اي
+
+682
+01:06:53,530 --> 01:07:03,450
+بالساوية اي في عشرة اقل ستة اس بي هاي معادلة اتنين
+
+683
+01:07:06,810 --> 01:07:14,070
+يعني لو قسمت اتنين على .. على او واحد على اتنين
+
+684
+01:07:14,070 --> 01:07:23,330
+يعني نحكي divide واحد على اتنين هكون عندي F S U T
+
+685
+01:07:23,330 --> 01:07:34,730
+على S E هتروح A مع A هتكون عشر أقصد تلاتة أقصد B
+
+686
+01:07:35,840 --> 01:07:44,080
+على عشرة اقص ستة اقص بي المنطقة هتكون عشرة اقص
+
+687
+01:07:44,080 --> 01:07:49,580
+تلاتة على عشرة اقص ستة هتكون عشرة اقص سالب تلاتة
+
+688
+01:07:49,580 --> 01:07:59,060
+اقص بي يعني هتساوي عشرة اقص سالب تلاتة بي يعني لو
+
+689
+01:07:59,060 --> 01:08:11,080
+أخدت log الطرفين هكون دي logالـ F S U T على S A
+
+690
+01:08:11,080 --> 01:08:14,100
+بيستوى
+
+691
+01:08:14,100 --> 01:08:21,940
+ناقص تلاتة B log العشرة log العشرة مش بيستوى واحد
+
+692
+01:08:21,940 --> 01:08:28,780
+يعني هذا معناته هتستوى minus تلاتة B يعني B هتستوى
+
+693
+01:08:28,780 --> 01:08:49,310
+minus تلتلغ ال F S U T على S A طيب
+
+694
+01:08:49,310 --> 01:08:53,830
+معناته ال B بسواه ناقص لغ ال F S U T على S E
+
+695
+01:09:08,780 --> 01:09:19,580
+إذا كان عندي إذا كان عندي إذا كان عندي إذا
+
+696
+01:09:19,580 --> 01:09:19,820
+كان عندي إذا كان عندي إذا كان عندي إذا كان عندي
+
+697
+01:09:19,820 --> 01:09:20,280
+إذا كان عندي إذا كان عندي إذا كان عندي إذا كان
+
+698
+01:09:20,280 --> 01:09:20,280
+عندي إذا كان عندي إذا كان عندي إذا كان عندي إذا
+
+699
+01:09:20,280 --> 01:09:20,340
+كان عندي إذا كان عندي إذا كان عندي إذا كان عندي
+
+700
+01:09:20,340 --> 01:09:21,140
+إذا كان عندي إذا كان عندي إذا كان عندي إذا كان
+
+701
+01:09:21,140 --> 01:09:21,760
+عندي إذا كان عندي إذا كان عندي إذا كان عندي إذا
+
+702
+01:09:21,760 --> 01:09:22,480
+كان عندي إذا كان عندي إذا كان عندي إذا كان عندي
+
+703
+01:09:22,480 --> 01:09:25,560
+إذا كان عندي إذا كان عندي إذا كان عندي إذا كان
+
+704
+01:09:25,560 --> 01:09:25,580
+عندي إذا كان عندي إذا كان عندي إذا كان عندي إذا
+
+705
+01:09:25,580 --> 01:09:25,680
+كان عندي إذا كان عندي إذا كان عندي إذا كان عندي
+
+706
+01:09:25,680 --> 01:09:36,000
+إذا كان عندي إذا كان عندي إذا كان عندي إذا كان
+
+707
+01:09:36,000 --> 01:09:42,620
+عندي إذا كان عنان اسمي يعني هتكون ال sigma
+
+708
+01:09:42,620 --> 01:09:58,300
+reversal على هكون
+
+709
+01:09:58,300 --> 01:10:03,360
+ال sigma reversal على
+
+710
+01:10:03,360 --> 01:10:09,780
+aبساوة N أُس B لأخذت log الطرفين هكون log sigma
+
+711
+01:10:09,780 --> 01:10:17,740
+reversible على A بساوة B أو ممكن أحكي انه مباشرة
+
+712
+01:10:17,740 --> 01:10:23,020
+عارف انه نجرب أخد ال log ان ال N بساوة sigma
+
+713
+01:10:23,020 --> 01:10:30,750
+reversible على A أُس 1 على Bو B احنا حاسبينها اللي
+
+714
+01:10:30,750 --> 01:10:39,870
+هي ناقص تلت ال log اللي هي F S U T على ال S
+
+715
+01:10:43,860 --> 01:10:47,060
+طبعا ال typical S underground is only applicable
+
+716
+01:10:47,060 --> 01:10:51,580
+for a completely reversed stress situation لأن هو
+
+717
+01:10:51,580 --> 01:10:55,720
+هي كان عمل لما أنا عملت جبت ال standard specimen
+
+718
+01:10:55,720 --> 01:10:59,000
+كان متعرض ل completely reversed stress completely
+
+719
+01:10:59,000 --> 01:11:03,880
+reversed stress وبالتالي ال equations هذه is
+
+720
+01:11:03,880 --> 01:11:06,180
+applicable for a completely reversed stress
+
+721
+01:11:06,180 --> 01:11:10,370
+situationfor other stress situations لحالات stress
+
+722
+01:11:10,370 --> 01:11:13,810
+situations اللي ال stress بيكونش completely
+
+723
+01:11:13,810 --> 01:11:17,530
+reversed a completely reversed stress with the
+
+724
+01:11:17,530 --> 01:11:21,510
+same life expectancy must be used on the S
+
+725
+01:11:21,510 --> 01:11:24,930
+underground بدنا نحسب اللي هو equivalent
+
+726
+01:11:24,930 --> 01:11:30,150
+equivalent completely reversed stress اللي بيعطي
+
+727
+01:11:30,150 --> 01:11:35,430
+نفس العمر لل stress level الحقيقي أو ال loading
+
+728
+01:11:35,430 --> 01:11:36,070
+الحقيقي
+
+729
+01:11:40,640 --> 01:11:45,060
+احنا so far عملنا المعادلة بين العشرة أس تلاتة
+
+730
+01:11:45,060 --> 01:11:51,290
+وعشرة أس ستة برضه في الفترة العمر بين واحدو10 اقص
+
+731
+01:11:51,290 --> 01:11:56,930
+3 ممكن اعمل معادلة خطية بنفس ال logic السابق هتطلع
+
+732
+01:11:56,930 --> 01:12:06,330
+المعادلة ال sf بيساوي sut في n اقص log f على 3 هذا
+
+733
+01:12:06,330 --> 01:12:12,830
+في حالة طبعا المعادلة هتتم اشتقاقها based on two
+
+734
+01:12:12,830 --> 01:12:17,940
+points اللي هي one point اللي هي هذهواحد و S U T و
+
+735
+01:12:17,940 --> 01:12:21,900
+النقطة التانية اللي هي عشر عقوس تلاتة و F S U T
+
+736
+01:12:21,900 --> 01:12:26,820
+عملت linear fit بين النقطتين هدول و حسبت اللي هي S
+
+737
+01:12:26,820 --> 01:12:42,500
+F بسوا و S U T في N أسلوك F على تلاتة شوف
+
+738
+01:12:42,500 --> 01:12:42,920
+example
+
+739
+01:13:03,010 --> 01:13:11,730
+given a 1050 hot rolled steel حديد رقمه عشرة خمسين
+
+740
+01:13:11,730 --> 01:13:15,670
+hot rolled عشرة خمسين نسبة الكربون في نصف بالمية
+
+741
+01:13:15,670 --> 01:13:20,810
+point five percent estimate the rotating beam
+
+742
+01:13:20,810 --> 01:13:31,810
+endurance limit بده احسب ال SE prime الان
+
+743
+01:13:32,930 --> 01:13:37,510
+الـ SE Prime نرجع
+
+744
+01:13:37,510 --> 01:13:44,050
+للمعادلات هي
+
+745
+01:13:44,050 --> 01:13:50,530
+هذه ال SE Prime بتساوي في حتة ال English net
+
+746
+01:13:50,530 --> 01:14:00,450
+بتساوي نص ال SUT إذا كانت ال SUT
+
+747
+01:14:03,000 --> 01:14:07,480
+أقل أو يساوي 200 كيلو pound per square inch اللي
+
+748
+01:14:07,480 --> 01:14:13,500
+هي عبارة عن 1400 ميجاباسكالة أو
+
+749
+01:14:13,500 --> 01:14:20,620
+بيساوي 100 كيلو pound per square inch لو تكون ال
+
+750
+01:14:20,620 --> 01:14:29,360
+SUT أكبر من 200 كيلو pound per square inchأو بالـ
+
+751
+01:14:29,360 --> 01:14:35,240
+metric units اللي هي عبارة عن 700 ميجا بسكال لما
+
+752
+01:14:35,240 --> 01:14:42,180
+ال SUT أكبر من 1400 ميجا بسكال هذه الاسئلة
+
+753
+01:14:42,180 --> 01:14:47,060
+الابراهية مانا اتبع الزمن ايش اشوف
+
+754
+01:14:47,060 --> 01:14:52,360
+ال SUT ال SUT ما هو اللي هاجيبها هاجيبها من
+
+755
+01:14:52,360 --> 01:14:55,940
+الجداول نروح على ال appendix في الكتاب
+
+756
+01:15:01,980 --> 01:15:09,580
+هناك كده لنا اللي هو الف
+
+757
+01:15:09,580 --> 01:15:14,940
+و خمسين الف
+
+758
+01:15:14,940 --> 01:15:17,500
+و خمسين ايه؟
+
+759
+01:15:28,290 --> 01:15:32,870
+معناته من تابل A A واحد و عشرين تابل A واحد و
+
+760
+01:15:32,870 --> 01:15:40,070
+عشرين هو حكيها ليه الحديد
+
+761
+01:15:40,070 --> 01:15:54,250
+عند ألف و خمسين خينا
+
+762
+01:15:54,250 --> 01:15:56,010
+نطلع على ال end notes
+
+763
+01:16:15,340 --> 01:16:21,520
+عندي الف و خمسين hot
+
+764
+01:16:21,520 --> 01:16:22,720
+rolled
+
+765
+01:16:24,900 --> 01:16:31,620
+steel طالع عندى هنا في جدول عندى الف و خمسين في
+
+766
+01:16:31,620 --> 01:16:34,840
+quenched and timbered في تلت أنواع quenched and
+
+767
+01:16:34,840 --> 01:16:41,160
+timbered هين
+
+768
+01:16:41,160 --> 01:16:47,720
+معطيني درجة الحرارة هين
+
+769
+01:16:47,720 --> 01:16:51,840
+عندى normalized عندين annealed
+
+770
+01:16:53,500 --> 01:16:57,480
+و هى المعطلة ال tensile and tensile strength خلينى
+
+771
+01:16:57,480 --> 01:17:18,580
+بس أعلم على المنطقة هذه خلينى
+
+772
+01:17:18,580 --> 01:17:19,600
+أعلم على المنطقة هذه
+
+773
+01:17:23,890 --> 01:17:27,390
+لاحظوا quenched and tempered عند أربعمائة فيهران
+
+774
+01:17:27,390 --> 01:17:30,950
+.. عند متين وخمس فيهرانهاي بتعطينا ال .. ال .. ال
+
+775
+01:17:30,950 --> 01:17:33,710
+.. ال ultimate tensile strength الف ومية وعشرين
+
+776
+01:17:33,710 --> 01:17:37,030
+عند أربعمائة وخمسة وعشر فيهرانهاي بتعطينا الف
+
+777
+01:17:37,030 --> 01:17:42,190
+وتسعين عند سبعمية وسبعتاش بيعطينا ال .. ال tensile
+
+778
+01:17:42,190 --> 01:17:46,210
+strength سبعمية وسبعتاش normalized سبعمية و تمانية
+
+779
+01:17:46,210 --> 01:17:51,720
+واربعين and yield ستمية وستةو تلاتين واضح ان عندنا
+
+780
+01:17:51,720 --> 01:17:57,580
+في المعلومات في نقص الآن الحديد ال ال الف و خمسين
+
+781
+01:17:57,580 --> 01:18:01,220
+خواصه الميكانيكية بتعتمد على المعالج الحراري اللي
+
+782
+01:18:01,220 --> 01:18:04,640
+بتستويله يعني واضح ان عندي هنا معالجات مختلفة هنا
+
+783
+01:18:04,640 --> 01:18:10,580
+عم اعمل equation and temperingيعني صار تبريد مفاجئ
+
+784
+01:18:10,580 --> 01:18:14,200
+من ال astonite range يعني حوالي تسعمائة درجة لحد
+
+785
+01:18:14,200 --> 01:18:18,360
+حوالي متين و خمسة طبعا أكيد هكون الحديد قاسي إذا
+
+786
+01:18:18,360 --> 01:18:23,180
+بتروحوا على ال ال ال utectoid steel ال TT دياجرام
+
+787
+01:18:23,180 --> 01:18:30,040
+في ال material science بيكون
+
+788
+01:18:30,040 --> 01:18:35,880
+عنده جائش
+
+789
+01:18:35,880 --> 01:18:36,540
+زي هيك
+
+790
+01:18:41,370 --> 01:18:45,030
+انت بتحكي في حدود اللي هو ال temper لحجم 2 و 5
+
+791
+01:18:45,030 --> 01:18:48,470
+يعني في ال range هذا يعني على الأغلب هتكوّنش
+
+792
+01:18:48,470 --> 01:18:54,610
+عندهين .. هين ب night و هين عندنا per light .. هين
+
+793
+01:18:54,610 --> 01:19:04,450
+.. هين .. هين .. هين عند course per light هذا
+
+794
+01:19:04,450 --> 01:19:08,470
+material science و هذا fine per light
+
+795
+01:19:11,370 --> 01:19:16,510
+طب من ناحية strength البداية أقوى من ال fine per
+
+796
+01:19:16,510 --> 01:19:19,670
+light و ال fine per light أقوى من ال coarse per
+
+797
+01:19:19,670 --> 01:19:23,090
+light فمعناته ال strength بتاعة الحديد ان انا مثلا
+
+798
+01:19:23,090 --> 01:19:26,310
+ببدأ من ال astronaut range و ببرد مثلا لدرجة حرارة
+
+799
+01:19:26,310 --> 01:19:31,210
+بعدين ببرد الغرفة او مثلا ممكن اجي زي هيك
+
+800
+01:19:34,230 --> 01:19:37,550
+فبعتمد على نوع الخواص الميكانيكي بتعتمد على نوع
+
+801
+01:19:37,550 --> 01:19:41,030
+المعارج الحريري انا مافيش اللي معلومات كافية فبغض
+
+802
+01:19:41,030 --> 01:19:43,950
+النظر افرض ان هو الحديد الاول هذا افرض ان هو
+
+803
+01:19:43,950 --> 01:19:48,110
+equenched and tempered يعني كانت ال SUT عنده ال
+
+804
+01:19:48,110 --> 01:19:53,270
+SUT بساوي
+
+805
+01:19:53,270 --> 01:19:57,770
+مية
+
+806
+01:19:57,770 --> 01:19:58,890
+و تلاتة ستين
+
+807
+01:20:02,370 --> 01:20:05,810
+kilo pound per square inch هذا واضح اقل من 200
+
+808
+01:20:05,810 --> 01:20:13,790
+معناته ال SE prime بسواء نص ال SUT هتطلع واحد
+
+809
+01:20:13,790 --> 01:20:21,490
+تمانين و نص kilo pound per square inch نفس
+
+810
+01:20:21,490 --> 01:20:25,110
+المعدن نفس المعدن يعني انا بملاحظة درسته في ال
+
+811
+01:20:25,110 --> 01:20:27,590
+material science نفس المعدن
+
+812
+01:20:31,400 --> 01:20:38,100
+يعني ممكن اوصله بالمعالجة الحرارية يمكن يعني من
+
+813
+01:20:38,100 --> 01:20:41,460
+خمسة لعشر أضعاف ال strength بس عمله معالجة حرارية
+
+814
+01:20:41,460 --> 01:20:45,680
+معينة معناته بالمعالجات السيناريات .. السيناريهات
+
+815
+01:20:45,680 --> 01:20:49,640
+المعالجات الحرارية المختلفة ممكن أحصل على infinite
+
+816
+01:20:49,640 --> 01:20:53,020
+number of properties للحديد فكيف انا بعمل معالجة
+
+817
+01:20:53,020 --> 01:20:57,060
+حرارية كيف بحس .. كيف بتحكم خواص الحديد سواء في ..
+
+818
+01:20:57,060 --> 01:21:00,460
+من ناحية التقسية او من ناحية ال .. ال .. ال .. ال
+
+819
+01:21:00,460 --> 01:21:04,340
+.. ال kneelingأو التطرية للحديد يمكن اقص الحديد او
+
+820
+01:21:04,340 --> 01:21:09,520
+اطريه من خلال معالجات حرارية معينة هذا درسته
+
+821
+01:21:09,520 --> 01:21:15,300
+بالتفصيل في course of material science هذا المطلوب
+
+822
+01:21:15,300 --> 01:21:19,540
+الأول المطلوب التاني المطلوب التاني the endurance
+
+823
+01:21:19,540 --> 01:21:22,640
+strength of a polished rotating beam specimen
+
+824
+01:21:22,640 --> 01:21:27,660
+corresponding to 10 او 4 cycles to failure بده ال
+
+825
+01:21:27,660 --> 01:21:30,340
+sf المطلوب التاني
+
+826
+01:21:35,600 --> 01:21:41,020
+إذا كانت عندي ال cycles في ال N بالساوية عشر أقصى
+
+827
+01:21:41,020 --> 01:21:52,720
+أربعة بده ال sf prime أكمل هو ال sf نرجع
+
+828
+01:21:52,720 --> 01:22:00,680
+لل care بتاعنا فاكرين احنا ال care جزئناها لمناطق
+
+829
+01:22:02,200 --> 01:22:06,200
+المنطقة هذه من n بالساوية واحد لعشرة اقصى ثلاثة
+
+830
+01:22:06,200 --> 01:22:10,280
+والخط هذا من عشرة اقصى ثلاثة لعشرة اقصى ستة معناته
+
+831
+01:22:10,280 --> 01:22:15,000
+احنا هنستخدم معادلة for n من عشر اقصى ثلاثة عشرة
+
+832
+01:22:15,000 --> 01:22:19,920
+ستة معناته بتلزمنا معادلة الخط هذا اللي هي اللي هي
+
+833
+01:22:19,920 --> 01:22:28,300
+هذا الخط اللي هي SF عنده ال SF بالساوية a n اقصى b
+
+834
+01:22:28,300 --> 01:22:31,120
+طيب
+
+835
+01:22:33,400 --> 01:22:37,940
+ال A بيساوي
+
+836
+01:22:37,940 --> 01:22:50,380
+F S U T الكل تربية على S E طيب
+
+837
+01:22:50,380 --> 01:22:58,420
+مانا مطلوب ان احسب ايه؟ ال F ال S U T كانت عندى
+
+838
+01:22:58,420 --> 01:23:00,220
+مية و تلاتة و ستين
+
+839
+01:23:08,250 --> 01:23:13,890
+تقريبا هادي عندى point سبعة تمانية point تمانية
+
+840
+01:23:13,890 --> 01:23:20,810
+يعني تقريبا point سبعة تلتين
+
+841
+01:23:20,810 --> 01:23:28,510
+ها point سبعة تسعة تلاتة يعني ممكن احكي F من
+
+842
+01:23:28,510 --> 01:23:38,860
+figure F بالساوية ال F بالساوية pointسبعة تسعة
+
+843
+01:23:38,860 --> 01:23:46,840
+تلاتة من figure ستة تمانتاش منها
+
+844
+01:23:46,840 --> 01:23:51,660
+بحسب ال A هتكون تساوي اللي هي point سبعة تسعة
+
+845
+01:23:51,660 --> 01:24:00,020
+تلاتة في ال SUT مية و تلاتة و ستين الكل تربيع على
+
+846
+01:24:00,020 --> 01:24:06,180
+SE اللي هي واحد تمانين و نص بحسب ال A
+
+847
+01:24:10,700 --> 01:24:17,380
+point سبعة point
+
+848
+01:24:17,380 --> 01:24:28,520
+سبعة تسعة تلاتة في مية و تلاتة و ستين تقسيم
+
+849
+01:24:28,520 --> 01:24:31,740
+واحد
+
+850
+01:24:31,740 --> 01:24:36,520
+تمانين و
+
+851
+01:24:36,520 --> 01:24:36,840
+نص
+
+852
+01:24:41,840 --> 01:24:52,800
+طيب كمان مرة point سبعة تسعة تلاتة في مية و تلاتة
+
+853
+01:24:52,800 --> 01:24:58,060
+و ستين يساوي في
+
+854
+01:25:15,210 --> 01:25:25,570
+تقسيم واحد تمانين و نص بتطلع اتنين و خمسة
+
+855
+01:25:25,570 --> 01:25:33,770
+kilo pound per square inch هذه ال a هذه ايش ال a
+
+856
+01:25:33,770 --> 01:25:40,150
+ال b ال
+
+857
+01:25:40,150 --> 01:25:40,450
+b
+
+858
+01:25:43,570 --> 01:25:51,310
+سواء ناقص تلت log fsut
+
+859
+01:25:51,310 --> 01:26:03,230
+على sa ستكون سواء ناقص تلت log بنسبة تسعة تلتة في
+
+860
+01:26:03,230 --> 01:26:08,610
+مية و تلتة و ستين على sa اللي هي واحد تمانين و نص
+
+861
+01:26:08,610 --> 01:26:11,850
+و
+
+862
+01:26:11,850 --> 01:26:17,350
+بنحسبهااللي أنا حسبت a و b بروح أعوض عن a هنا
+
+863
+01:26:17,350 --> 01:26:22,390
+بيعوض عن a اللي هي هذه بيعوض عن b اللي هي هذه و
+
+864
+01:26:22,390 --> 01:26:31,330
+اللي أنا بستوى عشر قصر أربعة بحسب الأسافر
+
+865
+01:26:31,330 --> 01:26:36,670
+المطلوب
+
+866
+01:26:36,670 --> 01:26:43,400
+التالت the expected lifeof a polished rotating
+
+867
+01:26:43,400 --> 01:26:48,580
+beam specimen under a completely reversed stress
+
+868
+01:26:48,580 --> 01:26:57,160
+of 55 kilopound per square inch بدو
+
+869
+01:26:57,160 --> 01:26:59,780
+ال expected life of a polished rotating beam
+
+870
+01:26:59,780 --> 01:27:02,360
+specimen under a completely reversed stress of 55
+
+871
+01:27:02,360 --> 01:27:05,380
+kilopound per square inch
+
+872
+01:27:09,540 --> 01:27:15,900
+ال SE عندنا اكهن طلعت واحد تمانين وانص كيلو pound
+
+873
+01:27:15,900 --> 01:27:23,680
+per square inch بده ال life لما نكون ال .. ال ..
+
+874
+01:27:23,680 --> 01:27:28,660
+ال specimen تحت تأثير complete reverse stress of
+
+875
+01:27:28,660 --> 01:27:31,940
+fifty five kilo pound per square inch لحظوا الخمسة
+
+876
+01:27:31,940 --> 01:27:32,840
+خمسين اشمالها
+
+877
+01:27:35,280 --> 01:27:39,720
+أقل من واحد تمانية نص اللي هي ال endurance limit و
+
+878
+01:27:39,720 --> 01:27:43,680
+احنا عرفنا ال endurance limit هي ال stress level
+
+879
+01:27:43,680 --> 01:27:49,590
+stress amplitude level below whichthe part will
+
+880
+01:27:49,590 --> 01:27:54,950
+endure forever هو ال stress level اللي تحته القطع
+
+881
+01:27:54,950 --> 01:27:57,530
+هتعيش لمال نهاية معناته ال expected مافيش داعي
+
+882
+01:27:57,530 --> 01:28:03,590
+أحسب لأنه ال stress amplitude level is below ال SE
+
+883
+01:28:03,590 --> 01:28:09,030
+معناته هذا هعيش لمال نهاية معناته عمره لمال نهاية
+
+884
+01:28:09,030 --> 01:28:12,970
+لكن لو حكيتلك والله ال stress level تسعين kilo
+
+885
+01:28:12,970 --> 01:28:19,700
+pound التسعين أكبرمن الواحد تمانين و نص مانعة ما
+
+886
+01:28:19,700 --> 01:28:23,760
+زالت سن أكبر واحد و نص مانعة متوقع أن أعيش حياة
+
+887
+01:28:23,760 --> 01:28:28,360
+أطول أعيش
+
+888
+01:28:28,360 --> 01:28:32,520
+حياة أقصر طبعا او نحكي finite life بحسبها من نفس
+
+889
+01:28:32,520 --> 01:28:37,840
+المعادلة هذه أنا رودي حسبت ال A حسبت ال B و الأسأف
+
+890
+01:28:37,840 --> 01:28:40,520
+معطاة عندي و منها بحسب H ال N
+
+891
+01:29:01,850 --> 01:29:05,910
+طيب الان ال endurance limit اللي .. اللي .. اللي
+
+892
+01:29:05,910 --> 01:29:10,170
+احنا بنعرفها لحد اللحظة اللي هي ال S A prime is
+
+893
+01:29:10,170 --> 01:29:13,910
+for carefully prepared test specimen يعني ال S A
+
+894
+01:29:13,910 --> 01:29:22,250
+prime هدى تمقياسة و حسابها أو تم قياسة و حسابها من
+
+895
+01:29:22,250 --> 01:29:28,530
+خلال اللي هو ال standard fatigue test ال standard
+
+896
+01:29:28,530 --> 01:29:32,730
+fatigue test بتطلب standard أعينة معيارية الأعينة
+
+897
+01:29:32,730 --> 01:29:36,130
+المعيارية إلها شكل معين و إلها ال Polish بتكون
+
+898
+01:29:36,130 --> 01:29:39,930
+نعمة جدا رقم واحد ال loading بتاعها بيكون
+
+899
+01:29:39,930 --> 01:29:44,090
+completely reversed completely reversed bending
+
+900
+01:29:44,090 --> 01:29:49,170
+loadingالان القطع الميكانيكية اللى على أرض الواقع
+
+901
+01:29:49,170 --> 01:29:55,390
+بتكونش مواصفاتها مطابقة للعينة الميارية من حيث
+
+902
+01:29:55,390 --> 01:30:00,810
+الشكل الجيومتري و من حيث ال finish و من حيث ال
+
+903
+01:30:00,810 --> 01:30:07,050
+loading و من حيث الظروف المحيطة لدرجته الحرارةمن
+
+904
+01:30:07,050 --> 01:30:11,110
+حيث ال reliability فالظروف الحقيقية مختلفة عن
+
+905
+01:30:11,110 --> 01:30:16,050
+الظروف المعيارية هذا بيقودنا انه لو اختلفت .. لو
+
+906
+01:30:16,050 --> 01:30:19,030
+كانت الظروف الحقيقية او القطع الميكانيكية تحت
+
+907
+01:30:19,030 --> 01:30:24,490
+الدراسة مختلفة عن الظروف المعيارية فحص الإجهاد
+
+908
+01:30:24,490 --> 01:30:28,910
+التوتر ال fatigue test معناته we have to modify
+
+909
+01:30:29,780 --> 01:30:34,260
+القيمة اللى حصلنا عليها من ال standard fatigue
+
+910
+01:30:34,260 --> 01:30:37,040
+test specimen كمان مرة ال standard test test
+
+911
+01:30:37,040 --> 01:30:42,780
+standard fatigue test بيصير لعينة معيارية اللى لها
+
+912
+01:30:42,780 --> 01:30:46,100
+شكل معين اللى لها surface finish معينة ال loading
+
+913
+01:30:46,100 --> 01:30:49,320
+بيكون completely reverse bending أرض الواقع ممكن
+
+914
+01:30:49,320 --> 01:30:52,940
+يكون ال loading torsional ممكن يكون axial ممكن
+
+915
+01:30:52,940 --> 01:30:57,420
+يكون bending ممكن يكونcombination بين axel او
+
+916
+01:30:57,420 --> 01:31:00,400
+bending بين bending و torsion او بين bending و طلع
+
+917
+01:31:00,400 --> 01:31:04,700
+نتشير ففي متغيرات كتير الحجم ال size القطر تاع
+
+918
+01:31:04,700 --> 01:31:07,700
+القطع الميكانيكي مختلف عن العين المعيارية its
+
+919
+01:31:07,700 --> 01:31:14,000
+surface finish مختلفدرجة الحرارة مختلفة ممكن يكون
+
+920
+01:31:14,000 --> 01:31:17,400
+ال stress concentration ففي ظروف حقيقية مختلفة عن
+
+921
+01:31:17,400 --> 01:31:22,440
+الظروف الميارية هذا بتطلب ان اعمل انا to modify
+
+922
+01:31:22,440 --> 01:31:24,880
+the endurance limit to modify ال endurance limit I
+
+923
+01:31:24,880 --> 01:31:30,400
+need some modification factors معناتهبحتاج اعدل
+
+924
+01:31:30,400 --> 01:31:36,000
+هستخدم معادلة SE بيساوي K A K B K C K D K E K F S
+
+925
+01:31:36,000 --> 01:31:41,400
+E prime ال S E prime هي ال endurance limit for a
+
+926
+01:31:41,400 --> 01:31:44,900
+standard tensile specimen under completely
+
+927
+01:31:44,900 --> 01:31:51,060
+reversed bending loading ال K A factor بيعمل
+
+928
+01:31:51,060 --> 01:31:53,960
+correction لل surface condition ال roughness
+
+929
+01:31:53,960 --> 01:31:59,070
+مختلفة او ال finish مختلفال KB بيعمل correction ل
+
+930
+01:31:59,070 --> 01:32:05,710
+ال size القطر مثلا في العين المعيارية نص انش عطب
+
+931
+01:32:05,710 --> 01:32:10,450
+يمكن يكون واحد انش ال KC بيعمل correction لل load
+
+932
+01:32:10,450 --> 01:32:14,920
+factor ال load في حالة العين المعياريةاللي هو
+
+933
+01:32:14,920 --> 01:32:17,520
+bending .. completely reversed bending ممكن تكون
+
+934
+01:32:17,520 --> 01:32:22,020
+completely reversed .. completely reversed torsion
+
+935
+01:32:22,020 --> 01:32:24,900
+او تكون axial loading او combination بين هذه
+
+936
+01:32:24,900 --> 01:32:29,520
+الأنواع التحميلات المختلفة الآن العين المعيرية تم
+
+937
+01:32:29,520 --> 01:32:33,140
+فحصها عند درجة حرارة الغرفة لكن القطعة الميكانيكية
+
+938
+01:32:33,140 --> 01:32:39,730
+ممكن تكون قطعةفي بيئة الحرارة بتاعتها مرتفعة مثلا
+
+939
+01:32:39,730 --> 01:32:45,130
+وبالتالي محتاج اعمل تعديل البيانات عندما حكيت SE
+
+940
+01:32:45,130 --> 01:32:50,150
+prime بساهم نص ال SET كانت for a fifty percent
+
+941
+01:32:50,150 --> 01:32:55,570
+reliability of the data what if اذا كانت
+
+942
+01:32:55,570 --> 01:32:57,710
+reliability تسعين في المية او خمسين سنين في المية
+
+943
+01:32:57,710 --> 01:33:02,260
+او تسعة سنين في الميةالـ KF موصليني من
+
+944
+01:33:02,260 --> 01:33:05,400
+miscellaneous effects factor يعني عامل تعديل
+
+945
+01:33:05,400 --> 01:33:10,180
+لشغلات كتير يعني .. يعني غير متوقع ممكن يكون .. هل
+
+946
+01:33:10,180 --> 01:33:13,720
+القطع ممكن تشتغل في بيئة .. في بيئة بحرية يعني
+
+947
+01:33:13,720 --> 01:33:18,200
+عندك ملوحة عالية ممكن تشتغل في بيئة كيميائية ممكن
+
+948
+01:33:18,200 --> 01:33:24,500
+في عندك إجهادات residual stresses ممكن تشتغل في
+
+949
+01:33:24,500 --> 01:33:29,210
+بيئة فيها إشعاع ف ..هذه اللي بتاخذ قرار فيها
+
+950
+01:33:29,210 --> 01:33:34,930
+المصمم هو بيقدر انه I need محتاج انا اعمل
+
+951
+01:33:34,930 --> 01:33:39,850
+modification بنسبة 50% بنسبة 60% to take other
+
+952
+01:33:39,850 --> 01:33:45,510
+effects المحاضرة الجاي هندرس ال factors هدول
+
+953
+01:33:45,510 --> 01:33:51,550
+بالتفصيل كيف حساب كل factor على حدة بهدف الوصول ل
+
+954
+01:33:51,550 --> 01:33:55,330
+endurance limit للقطع الميكانيكية اللي هي موجودة
+
+955
+01:33:55,330 --> 01:33:56,570
+على أرض الواقع
+
diff --git a/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/cZA5kLPfQUI.srt b/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/cZA5kLPfQUI.srt
new file mode 100644
index 0000000000000000000000000000000000000000..7aa2a637501efa05a841aab4854f9c61ac54b8cf
--- /dev/null
+++ b/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/cZA5kLPfQUI.srt
@@ -0,0 +1,1219 @@
+1
+00:00:04,940 --> 00:00:08,400
+بسم الله الرحمن الرحيم السلام عليكم اليوم هنكمل
+
+2
+00:00:08,400 --> 00:00:13,440
+المحاضرة الرابعة في الـ ... أو الخامسة في الـ fatigue
+
+3
+00:00:13,440 --> 00:00:19,400
+... fatigue failure for variable loading اليوم
+
+4
+00:00:19,400 --> 00:00:23,340
+هنشوف how to characterize fluctuating stress خلينا
+
+5
+00:00:23,340 --> 00:00:27,880
+نعمل بعض الملاحظات كتقديم الآن، الـ S-N diagram
+
+6
+00:00:27,880 --> 00:00:34,900
+الذي هو ناتج عن فحص الفتيك المعياري، يطبق في حالة الـ
+
+7
+00:00:34,900 --> 00:00:41,100
+load كان completely reversed bending stress, other
+
+8
+00:00:41,100 --> 00:00:44,260
+stress situations التي تكون مش completely
+
+9
+00:00:44,260 --> 00:00:48,700
+reversed، لا نفعله.
+
+10
+00:00:48,700 --> 00:00:54,000
+استخدام الـ S-N diagram غير ممكن، معناته لازم أشوف طريقة
+
+11
+00:00:54,000 --> 00:00:57,000
+how to characterize fluctuating stresses
+
+12
+00:00:59,820 --> 00:01:02,480
+الباقي عندي مجموعة من الأمثلة، عندي مثلاً هنا
+
+13
+00:01:02,480 --> 00:01:08,680
+stress يتغير من هذا الزمن،  فيش fight or rebel،
+
+14
+00:01:08,680 --> 00:01:14,980
+عندي هذه حالة ثانية، هذه حالة ثالثة، ممكن تكون أي
+
+15
+00:01:14,980 --> 00:01:17,280
+curve، ممكن يكون شيء زي هكذا
+
+16
+00:01:25,440 --> 00:01:30,180
+هذا is fluctuating، لا هو sinusoid ولا هو repeated
+
+17
+00:01:30,180 --> 00:01:39,160
+ولا هو completely reversed الآن
+
+18
+00:01:39,160 --> 00:01:45,980
+خلينا نعمل بعض التعريفات عندي
+
+19
+00:01:45,980 --> 00:01:50,040
+هنا الزمن، وهنا
+
+20
+00:01:50,040 --> 00:01:57,510
+الـ stress، والـ stress يتغير طبقاً للـ curve هذا. هذا
+
+21
+00:01:57,510 --> 00:02:04,250
+الـ value  التي هي sigma minimum، و
+
+22
+00:02:04,250 --> 00:02:08,510
+هذه sigma
+
+23
+00:02:08,510 --> 00:02:17,730
+maximum، بدي أعرف الـ stress range، التي هي sigma R
+
+24
+00:02:21,880 --> 00:02:29,080
+بساوي sigma max ناقص sigma minimum، بتعرف
+
+25
+00:02:29,080 --> 00:02:35,040
+لسة الـ mean stress، هذه sigma
+
+26
+00:02:35,040 --> 00:02:42,340
+mean أو الـ mid range stress، sigma mean بساوي sigma
+
+27
+00:02:42,340 --> 00:02:50,220
+max زائد sigma minimum على اثنين، الـ average value، و
+
+28
+00:02:50,220 --> 00:02:54,420
+في الـ stress amplitude، الذي هو الـ stress level
+
+29
+00:02:54,420 --> 00:03:02,780
+above الـ average، sigma a، الـ sigma a بساوي sigma r
+
+30
+00:03:02,780 --> 00:03:08,580
+على اثنين، يعني بساوي sigma max ناقص sigma minimum
+
+31
+00:03:08,580 --> 00:03:16,240
+على اثنين، هذا الـ general case
+
+32
+00:03:19,580 --> 00:03:24,740
+case، في حالات خاصة، أول شيء completely reverse
+
+33
+00:03:24,740 --> 00:03:28,960
+stress، completely reversed، يعني الـ sigma M في الـ
+
+34
+00:03:28,960 --> 00:03:33,920
+completely reverse يكون الـ sigma M بساوي صفر
+
+35
+00:03:33,920 --> 00:03:38,020
+هذه
+
+36
+00:03:38,020 --> 00:03:47,150
+sigma alternating، وهذه sigma alternating في
+
+37
+00:03:47,150 --> 00:03:50,710
+repeated stress، يعني الـ stress يعني بتروح بين
+
+38
+00:03:50,710 --> 00:03:54,710
+صفر و maximum، maximum صفر، maximum صفر، maximum
+
+39
+00:03:54,710 --> 00:04:04,050
+بيكون هذا الـ sigma minimum بساوي صفر
+
+40
+00:04:04,050 --> 00:04:16,380
+و هذا الـ sigma max، هذا الـ sigma min، وهذا الـ sigma
+
+41
+00:04:16,380 --> 00:04:23,320
+alternating، في هذه الحالة، الـ sigma alternating بساوي
+
+42
+00:04:23,320 --> 00:04:38,900
+الـ sigma min بساوي الـ sigma max على اثنين، في
+
+43
+00:04:38,900 --> 00:04:39,960
+الـ stress ratio
+
+44
+00:04:50,340 --> 00:04:55,160
+هكذا، هذا هو sigma max، هذا
+
+45
+00:04:55,160 --> 00:05:00,460
+sigma minimum، هذا sigma alternating، sigma
+
+46
+00:05:00,460 --> 00:05:05,740
+alternating، هذا sigma mean، هذا sigma R، الـ sigma
+
+47
+00:05:05,740 --> 00:05:08,000
+mean، التي هي الـ average value، بين الـ maximum و الـ
+
+48
+00:05:08,000 --> 00:05:10,680
+minimum، الـ sigma alternating، الذي هو الـ stress
+
+49
+00:05:10,680 --> 00:05:12,380
+amplitude، الـ maximum والناقص والـ minimum على
+
+50
+00:05:12,380 --> 00:05:17,250
+اثنين، والـ stress ratio هي الـ ratio بين الـ minimum
+
+51
+00:05:17,250 --> 00:05:20,330
+stress والـ maximum stress level، والـ amplitude
+
+52
+00:05:20,330 --> 00:05:23,170
+ratio هي الـ ratio بين الـ stress amplitude، sigma a
+
+53
+00:05:23,170 --> 00:05:24,510
+على sigma m
+
+54
+00:05:44,320 --> 00:05:48,280
+and how to apply الـ KF for fluctuating stresses
+
+55
+00:05:48,280 --> 00:05:49,160
+case
+
+56
+00:05:52,480 --> 00:05:55,760
+for fluctuating loads at points with stress
+
+57
+00:05:55,760 --> 00:05:59,880
+concentration, the best approach is to design to
+
+58
+00:05:59,880 --> 00:06:02,960
+avoid all localized plastic strains، بدك تعمل
+
+59
+00:06:02,960 --> 00:06:07,020
+design لـ الـ mechanical part بحيث عند الـ stress
+
+60
+00:06:07,020 --> 00:06:10,420
+concentration ما ندخلش لـ plastic range، بحيث ما ندخلش لـ
+
+61
+00:06:10,420 --> 00:06:14,320
+plastic range، في هذه الحالة، إذا أنت مصمم بحيث
+
+62
+00:06:14,320 --> 00:06:19,190
+ما ندخلش لـ plastic range، الـ KF ممكن could be applied
+
+63
+00:06:19,190 --> 00:06:25,790
+لـ Sigma A و Sigma M، يعني بقى ضرب KF في Sigma
+
+64
+00:06:25,790 --> 00:06:31,730
+alternating التي هي nominal، و KF في Sigma M
+
+65
+00:06:31,730 --> 00:06:37,330
+nominal، هذا a few design بحيث أنك تتجنب دخول لـ
+
+66
+00:06:37,330 --> 00:06:41,470
+plastic range عند نقطة الـ stress concentration
+
+67
+00:06:46,520 --> 00:06:51,820
+when localized strain does occur، لما عندي ندخل لـ
+
+68
+00:06:51,820 --> 00:06:57,040
+plastic range، some methods، بعض الطرق، recommend
+
+69
+00:06:57,040 --> 00:07:02,760
+applying KF only to sigma alternating، يعني بعض
+
+70
+00:07:02,760 --> 00:07:09,520
+الطرق بيحكيلك استخدم KF مع sigma alternating فقط
+
+71
+00:07:09,520 --> 00:07:15,080
+ما تستخدموش مع الـ sigma mean، في طريقة التي اسمها
+
+72
+00:07:15,080 --> 00:07:19,500
+Dowling method، Dowling
+
+73
+00:07:19,500 --> 00:07:25,520
+method، في Dowling method، you apply KF to Sigma A
+
+74
+00:07:25,520 --> 00:07:32,720
+you applied KFM to Sigma M، طبعاً الـ KFM معطى
+
+75
+00:07:32,720 --> 00:07:40,110
+في المعادلة هذه، KFM بساوي KF في حالة كان KF في الـ
+
+76
+00:07:40,110 --> 00:07:45,870
+nominal maximum stress كانت أقل من الـ SY، يعني إذا
+
+77
+00:07:45,870 --> 00:07:51,910
+ما دخلتش locally لـ plastic range، بتكون الـ KFM
+
+78
+00:07:51,910 --> 00:07:59,230
+بساوي الـ KF، أو الـ KFM بساوي SY ناقص KF في
+
+79
+00:07:59,230 --> 00:08:02,410
+sigma alternating nominal على sigma mean nominal
+
+80
+00:08:02,410 --> 00:08:10,350
+في حالة أن KF، في حالة دخلت إيش؟ لـ plastic range، يعني
+
+81
+00:08:10,350 --> 00:08:13,350
+KF في الـ maximum of nominal stress أكبر من الـ SY
+
+82
+00:08:13,350 --> 00:08:19,710
+أو
+
+83
+00:08:19,710 --> 00:08:24,610
+الـ KFM بساوي صفر، لما كانت KF في القيمة المطلقة لـ
+
+84
+00:08:24,610 --> 00:08:27,550
+maximum of nominal stress ناقص الـ minimum of
+
+85
+00:08:27,550 --> 00:08:32,730
+nominal stress أكبر من 2SY، طبعاً الـ Sigma AO و
+
+86
+00:08:32,730 --> 00:08:38,140
+Sigma MO هي nominal stresses introduced by the laws
+
+87
+00:08:38,140 --> 00:08:43,400
+FA and FM without applying stress concentration
+
+88
+00:08:43,400 --> 00:08:47,720
+يعني أنا هذا الـ stress الذي أحسبه قبل ما أستخدم
+
+89
+00:08:47,720 --> 00:08:50,420
+الـ stress concentration factors
+
+90
+00:08:57,720 --> 00:09:01,620
+معناته إذا أنا صممت بحيث أتجنب دخول لـ plastic
+
+91
+00:09:01,620 --> 00:09:05,620
+range عند الـ ... عند الـ notch، حأحط الـ sigma
+
+92
+00:09:05,620 --> 00:09:08,700
+alternating بساوي KF في sigma alternating nominal
+
+93
+00:09:08,700 --> 00:09:13,940
+و sigma mean بساوي KF في sigma MO nominal، إذا
+
+94
+00:09:13,940 --> 00:09:19,280
+دخلت، ما أقدرش أتجنب، و locally دخلت لـ plastic range
+
+95
+00:09:19,280 --> 00:09:21,200
+بستخدم
+
+96
+00:09:22,370 --> 00:09:27,170
+معادلة سابقة، أستخدم dowling equation، أو إذا بدي
+
+97
+00:09:27,170 --> 00:09:31,590
+أكون محافظ، أحط الـ sigma a بساوي kf في sigma a
+
+98
+00:09:31,590 --> 00:09:40,730
+nominal، و أحط kfm بساوي واحد، kf بساوي واحد، يعني
+
+99
+00:09:40,730 --> 00:09:44,270
+يا أستخدم هذه، أو أستخدم معادلة 3639، التي هي
+
+100
+00:09:44,270 --> 00:09:50,210
+dowling equation، لأن
+
+101
+00:09:50,210 --> 00:09:56,590
+نأتي لـ design theories، هنبدأ في الـ modified Goodman
+
+102
+00:09:56,590 --> 00:10:01,950
+theory، لأن to set up a fatigue design theory
+
+103
+00:10:01,950 --> 00:10:07,810
+graphically، بأرسم محاور، المحور الأفقي يمثل الـ
+
+104
+00:10:07,810 --> 00:10:13,510
+sigma M، والمحور
+
+105
+00:10:13,510 --> 00:10:18,430
+الرأسي يمثل الـ sigma alternating
+
+106
+00:10:20,370 --> 00:10:26,730
+على نفس الـ figure، بدي أحط الـ yield criteria والـ
+
+107
+00:10:26,730 --> 00:10:31,510
+fatigue criteria، to define لي الـ criteria، أنا عندي
+
+108
+00:10:31,510 --> 00:10:36,870
+الذي هو الـ SY والـ
+
+109
+00:10:36,870 --> 00:10:45,620
+الـ SY for any loading condition كانت واقعة على
+
+110
+00:10:45,620 --> 00:10:49,380
+الخط هذا، أنا أبدأ يصير عندي yielding، الآن الـ fatigue
+
+111
+00:10:49,380 --> 00:10:57,320
+condition عند الـ SUT، في حالة المدفعات Goodman، وهنا
+
+112
+00:10:57,320 --> 00:10:58,280
+عند الـ SA
+
+113
+00:11:07,150 --> 00:11:12,130
+إذا الـ loading condition sigma m و sigma a، أي نقطة
+
+114
+00:11:12,130 --> 00:11:15,750
+واقعة هنا تمثل لي failure، يعني هكذا failure، جوا safe
+
+115
+00:11:15,750 --> 00:11:23,010
+برا failure، جوا safe، طبعاً
+
+116
+00:11:23,010 --> 00:11:27,170
+أنا في عندي هأتعامل
+
+117
+00:11:27,170 --> 00:11:36,750
+مع أربعة theories، عندي هذه الـ SY، الـ SUT، والـ SE
+
+118
+00:11:36,750 --> 00:11:45,430
+والـ SY، هذا الخط المتقطع يمثل الـ yield line، الخط
+
+119
+00:11:45,430 --> 00:11:49,850
+هذا الذي واصل بين SE و SE يمثل الـ fatigue failure line
+
+120
+00:11:49,850 --> 00:11:57,170
+التي هي تسمى الـ Soderberg line، جاي بين SY و SE، الخط
+
+121
+00:11:57,170 --> 00:12:01,930
+المنحنى الذي جاء بين SUT و SE يمثل Modified Goodman
+
+122
+00:12:01,930 --> 00:12:08,130
+Fatigue Line، الخط المنحنى الذي جاء بين SY بين S
+
+123
+00:12:08,130 --> 00:12:13,050
+Y و SE يمثل الـ Elliptic Fatigue Failure Theory
+
+124
+00:12:13,050 --> 00:12:18,810
+الـ curved line بين SUT و SE يمثل الـ Gerber Line
+
+125
+00:12:18,810 --> 00:12:25,610
+Fatigue Theory، والخط هذا يمثل الـ load line، هذه
+
+126
+00:12:27,910 --> 00:12:35,370
+هذه ممكن تكون عندي ... عندي sigma mean، وهذه sigma
+
+127
+00:12:35,370 --> 00:12:40,670
+alternating، لأن لما نمد الخط هذا هيتقطع، لو افترضت
+
+128
+00:12:40,670 --> 00:12:45,970
+أنا الـ ... الـ ... الـ design theory التي هي modified
+
+129
+00:12:45,970 --> 00:12:52,090
+Goodman، بمعنى أن هذه ستكون SM وهذه
+
+130
+00:12:53,330 --> 00:12:57,450
+SA، و الـ factor of safety في هذه الحالة الذي هو NF
+
+131
+00:12:57,450 --> 00:13:13,050
+بساوي SM على سيجما M، بساوي SA على سيجما A، يعني
+
+132
+00:13:13,050 --> 00:13:17,630
+اللحظة، المحور هذا يمثل الـ case عندما S يعني هنا
+
+133
+00:13:17,630 --> 00:13:19,890
+النقطة هذه، هذه النقطة
+
+134
+00:13:24,650 --> 00:13:30,170
+وصفر، يعني ما فيش alternation، ما فيش fluctuation هنا
+
+135
+00:13:30,170 --> 00:13:40,290
+النقطة هذه تمثل صفر و SE، يعني complete، هذه
+
+136
+00:13:40,290 --> 00:13:45,520
+complete reversed case، وهذه النقطة تمثل التي هي الـ
+
+137
+00:13:45,520 --> 00:13:48,420
+steady state case، يعني ما فيش عندي alternation أو
+
+138
+00:13:48,420 --> 00:13:51,700
+ما فيش عندي fluctuation، يعني الـ load ثابت، يعني هذه
+
+139
+00:13:51,700 --> 00:13:56,380
+الـ static case، وهذه الـ static case، وهذه الـ
+
+140
+00:13:56,380 --> 00:14:01,520
+completely reversed case، الآن، if any point in
+
+141
+00:14:01,520 --> 00:14:07,180
+between التي هي ... التي هي جزء منها في عندي mean
+
+142
+00:14:07,180 --> 00:14:10,380
+stress component، وفي عندي الـ alternating stress
+
+143
+00:14:10,380 --> 00:14:15,240
+component is defined by this line، إذا استخدمت
+
+144
+00:14:15,240 --> 00:14:19,660
+modified Goodman، or this curve، إذا استخدمت Gerber
+
+145
+00:14:19,660 --> 00:14:24,080
+criteria، أو this curve، إذا استخدمت الذي هو ASME
+
+146
+00:14:24,080 --> 00:14:28,060
+elliptic criteria، أو this line، إذا استخدمت
+
+147
+00:14:28,060 --> 00:14:29,100
+Soderberg criteria
+
+148
+00:14:47,300 --> 00:14:51,440
+الآن، الـ design theories، sigma alternating في حياة
+
+149
+00:14:51,440 --> 00:14:55,400
+Soderberg، Soderberg جاي بين الـ SE والـ SY، دائماً الـ SE
+
+150
+00:14:55,400 --> 00:14:59,020
+يأتي معها sigma alternating، والـ SY أو الـ SUT
+
+151
+00:14:59,020 --> 00:15:02,140
+يأتي معها sigma M، يعني هنا sigma A جاي بين الـ SE
+
+152
+00:15:02,140 --> 00:15:05,640
+والـ SY، sigma A على SE زي sigma M على SE بساوي
+
+153
+00:15:05,640 --> 00:15:08,710
+واحد، لأن هو الـ factor of safety، Modified Goodman
+
+154
+00:15:08,710 --> 00:15:12,550
+جاي بين SE و SUT، سيجما A على SE زي سيجما M على SUT
+
+155
+00:15:12,550 --> 00:15:15,690
+بساوي واحد، لـ N، الجيربر، جاي الـ non linear
+
+156
+00:15:15,690 --> 00:15:21,230
+بين SE و SUT، ستكون N، سيجما A على SE زي N سيجما M على
+
+157
+00:15:21,230 --> 00:15:24,350
+SUT، الكل بساوي واحد، الأزمة التي تكون non
+
+158
+00:15:24,350 --> 00:15:28,270
+linear، جاي بين SE و SY، N سيجما alternating على SE
+
+159
+00:15:28,270 --> 00:15:31,170
+الكل بساوي زي N سيجما M على SY الكل بساوي
+
+160
+00:15:31,170 --> 00:15:32,050
+واحد
+
+161
+00:15:38,100 --> 00:15:45,240
+الآن سنتطلع على الـ table 6-6 لـ 6-8، يعني عندي 6-6، 6-7، 6-
+
+162
+00:15:45,240 --> 00:15:51,460
+8، الـ table 6-6 معطيني الحسابات للمدفعات Goodman
+
+163
+00:15:51,460 --> 00:15:57,440
+المدفعات Goodman، إحنا حكينا جاية بين، عندي جاية بين
+
+164
+00:15:57,440 --> 00:16:05,460
+هذا
+
+165
+00:16:05,460 --> 00:16:13,550
+الـ yield، الـ yield line، هنا عندي sy، هنا sut، هنا sy
+
+166
+00:16:13,550 --> 00:16:25,170
+هنا sa، وهذا الـ load line، الـ load line، وهذا الـ
+
+167
+00:16:25,170 --> 00:16:29,310
+critical، الـ
+
+168
+00:16:29,310 --> 00:16:32,930
+critical load
+
+169
+00:16:32,930 --> 00:16:35,030
+line
+
+170
+00:16:47,620 --> 00:16:54,620
+هذا الخط الـ failure line، معرفة له علاقة التي هي SA
+
+171
+00:16:54,620 --> 00:17:09,560
+على SE زائد SM على SUT بساوي واحد، والـ
+
+172
+00:17:09,560 --> 00:17:13,040
+yield line هذا معادلته SA
+
+173
+00:17:14,520 --> 00:17:25,380
+على SY زائد SM على SY بساوي واحد، وهذا الـ load line
+
+174
+00:17:25,380 --> 00:17:39,860
+هذا sigma M، وهذا sigma A، النقطة قاطعة دول SM
+
+175
+00:17:43,530 --> 00:17:51,350
+و SA، و
+
+176
+00:17:51,350 --> 00:17:55,150
+الـ slope بتاعها ده، الذي هو الـ line الذي هو R، R
+
+177
+00:17:55,150 --> 00:18:12,210
+بساوي SM على SA، SA على SM بساوي
+
+178
+00:18:12,210 --> 00:18:12,890
+سيجما A
+
+179
+00:18:17,590 --> 00:18:22,790
+السطر الأول من الجدول، يوجد نقطة تقاطع load line
+
+180
+00:18:22,790 --> 00:18:29,770
+مع fatigue line، يعني النقطة هذه، السطر الأول هذا
+
+181
+00:18:29,770 --> 00:18:35,650
+يوجد نقطة تقاطع load line مع fatigue line التي
+
+182
+00:18:35,650 --> 00:18:43,950
+هي، بيحسب لي الـ SA بساوي R SE SUT زائد R SUT، الـ
+
+183
+00:18:43,950 --> 00:18:47,610
+SA بساوي R SE SUT على R SUT زائد SE، والـ SM
+
+184
+00:18:47,610 --> 00:18:55,190
+بساوي SE على R، السطر الثاني، بوجود تقاطع الـ load
+
+185
+00:18:55,190 --> 00:19:05,010
+line مع الـ yield line، هذه نقطة واحد، هذه واحد، اثنين
+
+186
+00:19:05,010 --> 00:19:
+
+223
+00:23:47,160 --> 00:23:50,860
+A عشرين والحديد ألف وخمسين
+
+224
+00:23:54,850 --> 00:24:02,050
+cauldron اللي عندنا اللي هو الـ SUT بتاعته مئة هذه
+
+225
+00:24:02,050 --> 00:24:08,530
+ألف وخمسين الـ
+
+226
+00:24:08,530 --> 00:24:15,330
+SUT بتاعته سوميت
+
+227
+00:24:15,330 --> 00:24:21,770
+كيلو pound per square inch والـ SY بالساوي
+
+228
+00:24:23,900 --> 00:24:28,780
+أربعة وثمانين كيلو
+
+229
+00:24:28,780 --> 00:24:41,360
+pound per square inch هذه A عشرين طيب
+
+230
+00:25:10,450 --> 00:25:17,310
+طيب هو معطيني أن الـ .. الـ .. الـ .. الـ .. الـ .. الـ
+
+231
+00:25:17,310 --> 00:25:17,470
+.. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ
+
+232
+00:25:17,470 --> 00:25:17,530
+الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ
+
+233
+00:25:17,530 --> 00:25:17,570
+.. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ
+
+234
+00:25:17,570 --> 00:25:17,870
+.. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ
+
+235
+00:25:17,870 --> 00:25:19,350
+.. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ
+
+236
+00:25:19,350 --> 00:25:19,550
+.. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ
+
+237
+00:25:19,550 --> 00:25:21,070
+.. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ
+
+238
+00:25:21,070 --> 00:25:26,150
+.. الـ .. الـ .. الـ .. الـ ..
+
+239
+00:25:26,150 --> 00:25:26,170
+الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ
+
+240
+00:25:26,170 --> 00:25:29,470
+.. الـ ..
+
+241
+00:25:29,470 --> 00:25:34,470
+الـ .. الـ ..
+
+242
+00:25:34,470 --> 00:25:35,990
+الـ
+
+243
+00:25:44,270 --> 00:25:51,030
+الآن الـ .. بار قطره الآن الـ stress sigma بشكل عام
+
+244
+00:25:51,030 --> 00:25:57,490
+sigma alternating بالساوي F alternating على الـ A
+
+245
+00:25:57,490 --> 00:26:07,110
+بالساوي أربعة F alternating على باي D تربيع طبعاً
+
+246
+00:26:07,110 --> 00:26:14,900
+هتساوي الـ sigma M برضه في الحالة هذه هتساوي أربعة في
+
+247
+00:26:14,900 --> 00:26:27,100
+ثمانية kilo pound على by في واحد ونصف تربيع يعني
+
+248
+00:26:27,100 --> 00:26:35,700
+هيكون أنه ثلاثين تقسيم ثلاثة point واحد أربعة تقسيم
+
+249
+00:26:35,700 --> 00:26:40,360
+واحد ونصف تقسيم واحد ونصف يساوي
+
+250
+00:26:42,670 --> 00:26:49,410
+بيطلع أربعة point خمسة ثلاثة أربعة point خمسة ثلاثة
+
+251
+00:26:49,410 --> 00:26:53,490
+kilo pound per square inch هذا الـ sigma main و
+
+252
+00:26:53,490 --> 00:26:54,110
+sigma alternative
+
+253
+00:27:13,000 --> 00:27:18,960
+الآن احنا هاي الرصبة عندي الـ SUT مئة الـ SUT
+
+254
+00:27:18,960 --> 00:27:28,000
+مئة هذه مئة هذه الـ SUT والـ SY أربعة وثمانين و
+
+255
+00:27:28,000 --> 00:27:31,500
+الـ SE طبعاً .. واللي هين عندي هين أربعة وثمانين
+
+256
+00:27:31,500 --> 00:27:37,080
+الـ SY مطلوب احسب إيش الـ SE في الأول ده احسب الـ
+
+257
+00:27:37,080 --> 00:27:44,780
+SE prime هتساوي نص الـ SUT هتكون نص في مئة هتكون
+
+258
+00:27:44,780 --> 00:27:50,160
+خمسين كيلو pound per square inch الآن هو حكى لي
+
+259
+00:27:50,160 --> 00:27:53,360
+machined معناه بتحسب الـ KA بتعمل modification
+
+260
+00:27:53,360 --> 00:28:04,360
+factors  الـ KA
+
+261
+00:28:04,360 --> 00:28:18,940
+الـ KA هو A SUT أس B هو Machined هتكون
+
+262
+00:28:18,940 --> 00:28:26,400
+الـ A اتنين point سبعة اتنين point سبعة في مئة الـ B
+
+263
+00:28:26,400 --> 00:28:30,120
+هتكون minus point اتنين ستة خمسة
+
+264
+00:28:38,450 --> 00:28:43,930
+مئة أقصى minus يساوي
+
+265
+00:28:43,930 --> 00:28:50,670
+في اتنين bond سبعة تطلع bond سبعة تسعة ثمانية bond
+
+266
+00:28:50,670 --> 00:29:02,290
+سبعة تسعة ثمانية هذه الـ KA الـ size factor الـ KB
+
+267
+00:29:07,490 --> 00:29:10,350
+في حالة axial loading أنا عندي axial loading KB
+
+268
+00:29:10,350 --> 00:29:21,570
+هتكون تساوي واحد الـ
+
+269
+00:29:21,570 --> 00:29:32,670
+KC for axial loading KC  سابون ثمانية خمسة الـ KD و
+
+270
+00:29:32,670 --> 00:29:41,460
+الـ KE معناته هتكون تساوي KD بتساوي KE بتساوي واحد ومنها
+
+271
+00:29:41,460 --> 00:29:51,220
+بحسب الـ SE هتكون KA اللي هي bond 7 تسعة ثمانية في
+
+272
+00:29:51,220 --> 00:29:56,280
+KB واحد في KC bond ثمانية خمسة في الـ SE prime اللي
+
+273
+00:29:56,280 --> 00:29:58,040
+هي خمسين
+
+274
+00:30:01,240 --> 00:30:08,180
+بونت سبعة تسعة ثمانية في بونت ثمانية خمسة في خمسين
+
+275
+00:30:08,180 --> 00:30:13,360
+تطلع ثلاثين بونت تسعة اتنين ثلاثين
+
+276
+00:30:13,360 --> 00:30:19,300
+بونت تسعة اتنين كيلو pound per square inch هذا الـ
+
+277
+00:30:19,300 --> 00:30:19,720
+S
+
+278
+00:30:53,520 --> 00:30:58,140
+الآن سيجما مين هذه nominal وهذه عشان nominal يعني
+
+279
+00:30:58,140 --> 00:31:04,760
+سيجما مين تساوي سيجما A حسب تساوي KF في الـ sigma A
+
+280
+00:31:04,760 --> 00:31:08,760
+كيف معطيني واحد point ثمانية خمسة في أربعة point
+
+281
+00:31:08,760 --> 00:31:13,780
+خمسة ثلاثة عندي
+
+282
+00:31:13,780 --> 00:31:18,380
+واحد point ثمانية خمسة في أربعة point خمسة ثلاثة
+
+283
+00:31:18,380 --> 00:31:23,560
+بيطلع ثمانية point ثلاثة ثمانية ثمانية point ثلاثة
+
+284
+00:31:23,560 --> 00:31:28,000
+ثمانية كيلو
+
+285
+00:31:28,000 --> 00:31:33,510
+pound per square inch معناه يقول عندي هنا ثمانية
+
+286
+00:31:33,510 --> 00:31:39,830
+point ثلاثة ثمانية اللي هي هذه الـ sigma mean وعندي
+
+287
+00:31:39,830 --> 00:31:43,270
+هي ثمانية point ثلاثة ثمانية اللي هي sigma
+
+288
+00:31:43,270 --> 00:31:52,550
+alternating معناته هذا هو الـ load line تبعي هذا الـ
+
+289
+00:31:52,550 --> 00:31:58,430
+load line تبعي لأن
+
+290
+00:31:58,430 --> 00:32:00,970
+عشان أوجد الـ fatigue factor of safety
+
+291
+00:32:10,730 --> 00:32:17,850
+هذه ستكون SM وهذه SA
+
+292
+00:32:17,850 --> 00:32:26,790
+SM وSA واضح سلوب الخط هذا الـ R بيساوي واحد لأن
+
+293
+00:32:26,790 --> 00:32:29,330
+سيجما M بيساوي سيجما الـ alternating معنى السلوب
+
+294
+00:32:29,330 --> 00:32:35,150
+إيش بيساوي واحد احنا بدنا جيربار criteria
+
+295
+00:32:40,330 --> 00:32:47,430
+معنى طبيعي احنا هنا هتكون عندي SA SA S
+
+296
+00:32:47,430 --> 00:32:59,590
+A هتكون تساوي تابع ست سابع هتكون R Square SUT
+
+297
+00:32:59,590 --> 00:33:11,310
+Square على اتنين SE في minus واحد زائد جذر التربيع
+
+298
+00:33:11,310 --> 00:33:26,990
+لواحد زائد اتنين SE على RSUT لكل
+
+299
+00:33:26,990 --> 00:33:33,590
+تربيع يعني أنا هاكون عندي واحد في الـ SUT اللي هي
+
+300
+00:33:33,590 --> 00:33:37,170
+مئة في
+
+301
+00:33:37,170 --> 00:33:50,090
+مئة تربيع على اتنين في SE تربيع
+
+302
+00:33:50,090 --> 00:33:53,250
+على اتنين في SE تربيع على اتنين في SE تربيع على
+
+303
+00:33:53,250 --> 00:33:54,490
+اتنين في SE تربيع على اتنين في SE تربيع على اتنين
+
+304
+00:33:54,490 --> 00:33:54,530
+تربيع على اتنين في SE تربيع على اتنين في SE تربيع
+
+305
+00:33:54,530 --> 00:33:55,830
+على اتنين في SE تربيع على اتنين في SE تربيع على
+
+306
+00:33:55,830 --> 00:33:56,470
+اتنين في SE تربيع على اتنين في SE تربيع على اتنين
+
+307
+00:33:56,470 --> 00:33:56,890
+في SE تربيع على اتنين في SE تربيع على اتنين في SE
+
+308
+00:33:56,890 --> 00:34:00,370
+تربيع على اتنين في SE تربيع على اتنين في SE تربيع
+
+309
+00:34:00,370 --> 00:34:05,430
+على اتنين في SE تربيع
+
+310
+00:34:09,030 --> 00:34:17,730
+هتطلع الـ SA عندي الـ SA هتطلع ثلاثين بونت سبعة
+
+311
+00:34:17,730 --> 00:34:22,450
+كيلو
+
+312
+00:34:22,450 --> 00:34:26,530
+pound per square inch معناه أن الـ fatigue factor
+
+313
+00:34:26,530 --> 00:34:34,970
+of safety الـ un fatigue هيكون يساوي SA على سيجما A
+
+314
+00:34:35,880 --> 00:34:41,640
+الـ SA اللي هي عندي ثلاثين point سبعة على سيجما
+
+315
+00:34:41,640 --> 00:34:52,440
+A اللي هي ثمانية point ثلاثة ثمانية ثلاثين
+
+316
+00:34:52,440 --> 00:34:58,160
+point سبعة تقسيم ثمانية point ثلاثة ثمانية يساوي
+
+317
+00:35:00,510 --> 00:35:19,690
+تطلع ثلاثة point ستة ستة ثلاثة point ستة ستة عشان
+
+318
+00:35:19,690 --> 00:35:25,230
+أحسب الـ ny لازم هذه نقطة واحد لازم أوجد احتياطيات
+
+319
+00:35:25,230 --> 00:35:32,990
+النقطة اتنين خدني ضحك هذا يسمى SM تاعة الـ yield
+
+320
+00:35:32,990 --> 00:35:41,590
+وهذه SM SA تاعة الـ yield وهذا الـ load line ماله
+
+321
+00:35:41,590 --> 00:35:45,890
+خمسة وأربعين درجة ومعناته الـ R بالساوي واحد نرجع
+
+322
+00:35:45,890 --> 00:35:56,630
+للجدول Gerber اللي هو الـ SA هتكون تساوي الـ SA
+
+323
+00:35:58,900 --> 00:36:06,900
+هتكون R في SY على واحد زائد R يعني هتكون واحد في
+
+324
+00:36:06,900 --> 00:36:10,980
+أربعة وثمانين على واحد زائد واحد يعني أربعة و
+
+325
+00:36:10,980 --> 00:36:14,740
+ثمانين على اتنين اتنين وأربعين كيلو pound per
+
+326
+00:36:14,740 --> 00:36:19,680
+square inch معنى
+
+327
+00:36:19,680 --> 00:36:20,180
+الـ NY
+
+328
+00:36:23,220 --> 00:36:28,520
+هيكون يساوي اللي هو SA على Sigma A اللي هي اتنين و
+
+329
+00:36:28,520 --> 00:36:37,260
+أربعين على ثمانية point ثلاثة ثمانية اتنين
+
+330
+00:36:37,260 --> 00:36:44,040
+وأربعين تقسيم ثمانية point ثلاثة ثمانية بيطلع خمسة
+
+331
+00:36:44,040 --> 00:36:45,860
+point أو واحد خمسة
+
+332
+00:36:49,880 --> 00:36:52,760
+واضح الـ factor of safety في حالة الـ yielding أعلى
+
+333
+00:36:52,760 --> 00:36:56,420
+من الـ factor of safety في حالة الفتيك معناته الـ
+
+334
+00:36:56,420 --> 00:37:01,820
+potential for fatigue failure أعلى من الـ potential
+
+335
+00:37:01,820 --> 00:37:04,720
+for yielding يعني هيصير له fatigue failure before
+
+336
+00:37:04,720 --> 00:37:11,600
+it yields طبعاً
+
+337
+00:37:11,600 --> 00:37:14,800
+الفرع الثاني نفس الفرع الأول بس هستخدم نظرية ثانية
+
+338
+00:37:14,800 --> 00:37:17,800
+أزمة elliptic fatigue line نفس الحال تماماً
+
+339
+00:37:20,730 --> 00:37:26,730
+محاضرة الجاية بن .. بنكمل بتكون إن شاء الله آخر
+
+340
+00:37:26,730 --> 00:37:31,590
+محاضرة في chapter 6 اللي هو fatigue criteria for
+
+341
+00:37:31,590 --> 00:37:33,930
+brittle materials أعطيكم العفو
+
diff --git a/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/cZA5kLPfQUI_postprocess.srt b/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/cZA5kLPfQUI_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..8262674c2b1c8e14794145904a41bfd21f64de69
--- /dev/null
+++ b/PL9fwy3NUQKwZqK3_UxZG78URbnIyFx5tq/cZA5kLPfQUI_postprocess.srt
@@ -0,0 +1,1364 @@
+1
+00:00:04,940 --> 00:00:08,400
+بسم الله الرحمن الرحيم السلام عليكم اليوم هنكمل
+
+2
+00:00:08,400 --> 00:00:13,440
+المحاضرة الرابعة في ال .. او الخامسة في ال fatigue
+
+3
+00:00:13,440 --> 00:00:19,400
+.. fatigue failure for variable loading اليوم
+
+4
+00:00:19,400 --> 00:00:23,340
+هنشوف how to characterize fluctuating stress خلينا
+
+5
+00:00:23,340 --> 00:00:27,880
+نعمل بعض الملاحظات كتقديم الان ال S and diagram
+
+6
+00:00:27,880 --> 00:00:34,900
+اللي هو ناتج عن فحص الفتيك المعيارييطبق في حالة ال
+
+7
+00:00:34,900 --> 00:00:41,100
+load كان completely reversed bending stress other
+
+8
+00:00:41,100 --> 00:00:44,260
+stress situations اللي بتكون مش completely
+
+9
+00:00:44,260 --> 00:00:48,700
+reversed بنفعش
+
+10
+00:00:48,700 --> 00:00:54,000
+استخدم ال as underground معناته لازم اشوف طريقة
+
+11
+00:00:54,000 --> 00:00:57,000
+how to characterize fluctuating stresses
+
+12
+00:00:59,820 --> 00:01:02,480
+الباقي عندي مجموعة من الأمثلة، عندي مثلا هنا
+
+13
+00:01:02,480 --> 00:01:08,680
+stress بتغير من هذا الزمن، فيش fight or rebel،
+
+14
+00:01:08,680 --> 00:01:14,980
+عندي هاي حالة تانية، هاي حالة تالتة، ممكن تكون أي
+
+15
+00:01:14,980 --> 00:01:17,280
+curve، ممكن تكون إشي زي هيك
+
+16
+00:01:25,440 --> 00:01:30,180
+هذا is fluctuating لا هو sinusoid ولا هو repeated
+
+17
+00:01:30,180 --> 00:01:39,160
+ولا هو completely reversed الآن
+
+18
+00:01:39,160 --> 00:01:45,980
+خليني أعمل بعض ال definitions عندي
+
+19
+00:01:45,980 --> 00:01:50,040
+هنا الزمن وهنا
+
+20
+00:01:50,040 --> 00:01:57,510
+ال stressو ال stress بتغير طبقا لل curve هذا هذا
+
+21
+00:01:57,510 --> 00:02:04,250
+ال value اللي هي sigma minimum و
+
+22
+00:02:04,250 --> 00:02:08,510
+هذه sigma
+
+23
+00:02:08,510 --> 00:02:17,730
+maximum بدي اعرف ال stress range اللي هي sigma R
+
+24
+00:02:21,880 --> 00:02:29,080
+بسوة sigma max minus sigma minimum بتعرف
+
+25
+00:02:29,080 --> 00:02:35,040
+لسه ال mean stress هذه sigma
+
+26
+00:02:35,040 --> 00:02:42,340
+mean او ال mid range stress sigma mean بسوة sigma
+
+27
+00:02:42,340 --> 00:02:50,220
+max زائد sigma minimum على اتنين ال average valueو
+
+28
+00:02:50,220 --> 00:02:54,420
+في ال stress amplitude اللي هو ال stress level
+
+29
+00:02:54,420 --> 00:03:02,780
+above ال average sigma a ال sigma a بسواس sigma r
+
+30
+00:03:02,780 --> 00:03:08,580
+على اتنين يعني بسواس sigma max minus sigma minimum
+
+31
+00:03:08,580 --> 00:03:16,240
+على اتنين هذا ال general case
+
+32
+00:03:19,580 --> 00:03:24,740
+case في حالات خاصة اول شي completely reverse
+
+33
+00:03:24,740 --> 00:03:28,960
+stress completely reversed يعني ال sigma M في ال
+
+34
+00:03:28,960 --> 00:03:33,920
+completely reverse يكون ال sigma M بالساوية سفر
+
+35
+00:03:33,920 --> 00:03:38,020
+هذه
+
+36
+00:03:38,020 --> 00:03:47,150
+sigma alternating وهذه sigmaAlternating فى
+
+37
+00:03:47,150 --> 00:03:50,710
+repeated stress توش يعني ال stress يعني بتروح بين
+
+38
+00:03:50,710 --> 00:03:54,710
+zero و maximum maximum zero maximum zero maximum
+
+39
+00:03:54,710 --> 00:04:04,050
+بيكون هذا ال sigma مين ال sigma minimum بيستوى سفر
+
+40
+00:04:04,050 --> 00:04:16,380
+و هاد ال sigma max هاد ال sigmaمين وهد ال sigma
+
+41
+00:04:16,380 --> 00:04:23,320
+alternating في الحال هد ال sigma alternating بستوى
+
+42
+00:04:23,320 --> 00:04:38,900
+ال sigma مين بستوى ال sigma max على اتنين في
+
+43
+00:04:38,900 --> 00:04:39,960
+ال stress ratio
+
+44
+00:04:50,340 --> 00:04:55,160
+هكذا هذا هو sigma max هذا
+
+45
+00:04:55,160 --> 00:05:00,460
+sigma minimum هذا sigma alternating sigma
+
+46
+00:05:00,460 --> 00:05:05,740
+alternating هذا sigma mean هذا sigma R ال sigma
+
+47
+00:05:05,740 --> 00:05:08,000
+mean اللي هي ال average value اللي ال maximum و ال
+
+48
+00:05:08,000 --> 00:05:10,680
+minimum ال sigma alternating اللي هو ال stress
+
+49
+00:05:10,680 --> 00:05:12,380
+amplitude ال maximum و النقص و ال minimum على
+
+50
+00:05:12,380 --> 00:05:17,250
+اتنينوال stress ratio هي ال ratio بين ال minimum
+
+51
+00:05:17,250 --> 00:05:20,330
+stress وال maximum stress level وال amplitude
+
+52
+00:05:20,330 --> 00:05:23,170
+ratio هي ال ratio بين ال stress amplitude sigma a
+
+53
+00:05:23,170 --> 00:05:24,510
+على sigma m
+
+54
+00:05:44,320 --> 00:05:48,280
+and how to apply ال KF for fluctuating stresses
+
+55
+00:05:48,280 --> 00:05:49,160
+case
+
+56
+00:05:52,480 --> 00:05:55,760
+for fluctuating loads at points with stress
+
+57
+00:05:55,760 --> 00:05:59,880
+concentration, the best approach is to design to
+
+58
+00:05:59,880 --> 00:06:02,960
+avoid all localized plastic streams بدك تعمل
+
+59
+00:06:02,960 --> 00:06:07,020
+design ل ال mechanical part بحيث عند ال stress
+
+60
+00:06:07,020 --> 00:06:10,420
+concentration مادخلش ل plastic range بحيث مادخلش ل
+
+61
+00:06:10,420 --> 00:06:14,320
+plastic range في الحالة هذه إذا أنت مصمم بحيث
+
+62
+00:06:14,320 --> 00:06:19,190
+مادخلش ل plastic rangeالـ KF ممكن could be applied
+
+63
+00:06:19,190 --> 00:06:25,790
+لـ Sigma A و Sigma M يعني بقى ضرب KF في Sigma
+
+64
+00:06:25,790 --> 00:06:31,730
+alternating اللي هي nominal و KF في Sigma M
+
+65
+00:06:31,730 --> 00:06:37,330
+nominal هذا a few design بحيث أنك تتجنب تدخل ل
+
+66
+00:06:37,330 --> 00:06:41,470
+plastic range عند نقطة ال stress concentration
+
+67
+00:06:46,520 --> 00:06:51,820
+when localized strain does occur لما عندي أدخل ل
+
+68
+00:06:51,820 --> 00:06:57,040
+plastic range some methods بعض الطرق recommend
+
+69
+00:06:57,040 --> 00:07:02,760
+applying KF only to sigma alternating يعني بعض
+
+70
+00:07:02,760 --> 00:07:09,520
+الطرق بيحكيلك استخدم KF مع sigma alternating فقط
+
+71
+00:07:09,520 --> 00:07:15,080
+ما تستخدموش مع ال sigma meanفي طريقة اللي اسمها
+
+72
+00:07:15,080 --> 00:07:19,500
+Dowling method Dowling
+
+73
+00:07:19,500 --> 00:07:25,520
+method في Dowling method you apply KF to Sigma A
+
+74
+00:07:25,520 --> 00:07:32,720
+you applied KFM to Sigma M طبعا ال KFM معطب
+
+75
+00:07:32,720 --> 00:07:40,110
+المعادلة هذه KFM بيستوى KFفي حال كان دي KF في ال
+
+76
+00:07:40,110 --> 00:07:45,870
+nominal maximum stress كانت أقل من ال SY يعني إذا
+
+77
+00:07:45,870 --> 00:07:51,910
+ما دخلتش locally ل plastic range بتكون ال KF M
+
+78
+00:07:51,910 --> 00:07:59,230
+بيساوي ال KF أو ال KF M بيساوي SY minus KF في
+
+79
+00:07:59,230 --> 00:08:02,410
+sigma alternating nominal على sigma mean nominal
+
+80
+00:08:02,410 --> 00:08:10,350
+في حال ان KF في حال دخلت إيش؟لـ plastic range يعني
+
+81
+00:08:10,350 --> 00:08:13,350
+كف في ال maximum of nominal stress أكبر من ال SY
+
+82
+00:08:13,350 --> 00:08:19,710
+أو
+
+83
+00:08:19,710 --> 00:08:24,610
+الكف M بيستوى Zero لما كانت كف في القيمة المطلقة ل
+
+84
+00:08:24,610 --> 00:08:27,550
+maximum of nominal stress minus ال minimum of
+
+85
+00:08:27,550 --> 00:08:32,730
+nominal stress أكبر من 2SY طبعا ال Sigma AO و
+
+86
+00:08:32,730 --> 00:08:38,140
+Sigma MO هي nominal stressesintroduced by the laws
+
+87
+00:08:38,140 --> 00:08:43,400
+FA and FM without applying stress concentration
+
+88
+00:08:43,400 --> 00:08:47,720
+يعني أنا هذا ال stress اللي بحسبها قبل ما استخدم
+
+89
+00:08:47,720 --> 00:08:50,420
+ال stress concentration factors
+
+90
+00:08:57,720 --> 00:09:01,620
+معناته إذا أنا صممت بحيث أتجنب أدخل ل plastic
+
+91
+00:09:01,620 --> 00:09:05,620
+range عند ال .. عند ال notch هحط ال sigma
+
+92
+00:09:05,620 --> 00:09:08,700
+alternating بيساوي KF في sigma alternating nominal
+
+93
+00:09:08,700 --> 00:09:13,940
+و sigma mean بيساوي KF في sigma MO nominal إذا
+
+94
+00:09:13,940 --> 00:09:19,280
+دخلت ماقدرش أتجنب و locally دخلت ل plastic range
+
+95
+00:09:19,280 --> 00:09:21,200
+بستخدم
+
+96
+00:09:22,370 --> 00:09:27,170
+معادلة سابق بستخدم dowling equation او اذا بدى
+
+97
+00:09:27,170 --> 00:09:31,590
+اكون محافظ بحط ال sigma a بيساوي kf في sigma a
+
+98
+00:09:31,590 --> 00:09:40,730
+nominal و بحط kfm بيساوي واحد كف بيساوي واحد يعني
+
+99
+00:09:40,730 --> 00:09:44,270
+يا بستخدم هذه او بستخدم معادلة 3639 اللي هي
+
+100
+00:09:44,270 --> 00:09:50,210
+dowling equation لان
+
+101
+00:09:50,210 --> 00:09:56,590
+نيجي ل design theoriesهنبدأ في ال modified godman
+
+102
+00:09:56,590 --> 00:10:01,950
+theory لأن to set up a fatigue design theory
+
+103
+00:10:01,950 --> 00:10:07,810
+graphically بأرسم محاور المحور الأفقي بيمثلي ال
+
+104
+00:10:07,810 --> 00:10:13,510
+sigma M والمحور
+
+105
+00:10:13,510 --> 00:10:18,430
+الرأسي بيمثل ال sigma alternating
+
+106
+00:10:20,370 --> 00:10:26,730
+ع نفس ال figure بدي احط ال yield criteria و ال
+
+107
+00:10:26,730 --> 00:10:31,510
+fatigue criteria to define لي ال criteria انا عندي
+
+108
+00:10:31,510 --> 00:10:36,870
+اللي هو ال S Y و
+
+109
+00:10:36,870 --> 00:10:45,620
+ال S Y for any loading conditionكانت واقعة على
+
+110
+00:10:45,620 --> 00:10:49,380
+الخط هذا انا ببدأ يصير اندي ييلدنج الان ال fatigue
+
+111
+00:10:49,380 --> 00:10:57,320
+condition عند ال SUT في حالة المدفعات Godman وهنا
+
+112
+00:10:57,320 --> 00:10:58,280
+عند ال SA
+
+113
+00:11:07,150 --> 00:11:12,130
+إذا ال loading condition sigma m و sigma a أي نقطة
+
+114
+00:11:12,130 --> 00:11:15,750
+واقعة هتمثل ليه failure يعني هيك failure جوا safe
+
+115
+00:11:15,750 --> 00:11:23,010
+برا failure جوا safe طبعا
+
+116
+00:11:23,010 --> 00:11:27,170
+انا في عندي هتعامل
+
+117
+00:11:27,170 --> 00:11:36,750
+مع أربعة theoriesعندي هذه الـ SY الـ SUT و الـ SE
+
+118
+00:11:36,750 --> 00:11:45,430
+و الـ SY هذا الخط المتقطع بيمثل ال yield line الخط
+
+119
+00:11:45,430 --> 00:11:49,850
+هذا اللي واصل بين SE و SE بيمثل الفتيك فيلر line
+
+120
+00:11:49,850 --> 00:11:57,170
+اللي هو تسمى ال soda berg line جاي بين SY و SEالخط
+
+121
+00:11:57,170 --> 00:12:01,930
+العدل اللي جاء بين SUT و SE بمثل Modified Godman
+
+122
+00:12:01,930 --> 00:12:08,130
+Fatigue Lineالخط ال curved اللي جاء بين S Y بين S
+
+123
+00:12:08,130 --> 00:12:13,050
+Y و S E مثلي الأزم Elliptic Fatigue Failure Theory
+
+124
+00:12:13,050 --> 00:12:18,810
+ال curved line بين S U T و S E مثلي ال Gerber Line
+
+125
+00:12:18,810 --> 00:12:25,610
+Fatigue Theory و الخط هذا مثلي ال load line هذه
+
+126
+00:12:27,910 --> 00:12:35,370
+هذه ممكن تكون عندي .. عندي sigma mean وهذه sigma
+
+127
+00:12:35,370 --> 00:12:40,670
+alternating لأن لما نمد الخط هذا هيتقطع لو افترضت
+
+128
+00:12:40,670 --> 00:12:45,970
+انا ال .. ال .. ال design theory اللي هي modified
+
+129
+00:12:45,970 --> 00:12:52,090
+code بمعنى ان هذه هتكون SM وهذه
+
+130
+00:12:53,330 --> 00:12:57,450
+S A و ال factor of state في الحالة هذه اللي هو NF
+
+131
+00:12:57,450 --> 00:13:13,050
+بساوي SM على سيجما M بساوية S A على سيجما A يعني
+
+132
+00:13:13,050 --> 00:13:17,630
+اللحظ المحور هذا بمثل ال case عندها S يعني هنا
+
+133
+00:13:17,630 --> 00:13:19,890
+النقطة هذه هذه النقطة
+
+134
+00:13:24,650 --> 00:13:30,170
+و سفر يعني مافيش alternation مافيش fluctuation هنا
+
+135
+00:13:30,170 --> 00:13:40,290
+النقطة هذه بتمثل سفر و أس إيه يعني complete هذه
+
+136
+00:13:40,290 --> 00:13:45,520
+complete reversed case وهذه النقطة تمثلاللي هي ال
+
+137
+00:13:45,520 --> 00:13:48,420
+steady state case يعني مافيش عندى alternation أو
+
+138
+00:13:48,420 --> 00:13:51,700
+مافيش عندى fluctuation يعني ال load ثابت يعني هذه
+
+139
+00:13:51,700 --> 00:13:56,380
+ال static case وهذه ال static case وهذه ال
+
+140
+00:13:56,380 --> 00:14:01,520
+completely reversed case الآن if any point in
+
+141
+00:14:01,520 --> 00:14:07,180
+betweenاللي هي .. اللي هي جزء منها في عندى mean
+
+142
+00:14:07,180 --> 00:14:10,380
+stress component و في عندى ال alternating stress
+
+143
+00:14:10,380 --> 00:14:15,240
+component is defined by this line اذا استخدمت
+
+144
+00:14:15,240 --> 00:14:19,660
+modified Godman or this curve اذا استخدمت Gerber
+
+145
+00:14:19,660 --> 00:14:24,080
+criteria او this curve اذا استخدمت اللي هو asthma
+
+146
+00:14:24,080 --> 00:14:28,060
+elliptic criteria او this line اذا استخدمت
+
+147
+00:14:28,060 --> 00:14:29,100
+Soderberg criteria
+
+148
+00:14:47,300 --> 00:14:51,440
+الان ال design theories sigma alternating في حياة
+
+149
+00:14:51,440 --> 00:14:55,400
+صدربرج صدربرج جاي بين ال SE و ال SY دايما ال SE
+
+150
+00:14:55,400 --> 00:14:59,020
+بيجي معاها sigma alternating و ال SY او ال SUT
+
+151
+00:14:59,020 --> 00:15:02,140
+بيجي معاها sigma M يعني هنا sigma A جاي بين ال SE
+
+152
+00:15:02,140 --> 00:15:05,640
+و ال SY sigma A على SE زي sigma M على SE بيستوى
+
+153
+00:15:05,640 --> 00:15:08,710
+واحدة لان هو ال factor of safetyModified Godman
+
+154
+00:15:08,710 --> 00:15:12,550
+جاي بين SE و SUT سجما A على SE زي سجما M على SUT
+
+155
+00:15:12,550 --> 00:15:15,690
+بالساوية واحدة ل N الجيربار الجاي ال non linear
+
+156
+00:15:15,690 --> 00:15:21,230
+بين SE و SUT هتكون N سجما A على SE زي N سجما M على
+
+157
+00:15:21,230 --> 00:15:24,350
+SUT الكتر بيه بالساوية واحد الأزمة اللي بتكن non
+
+158
+00:15:24,350 --> 00:15:28,270
+linear جاي بين SE و SY N سجما alternating على SE
+
+159
+00:15:28,270 --> 00:15:31,170
+الكتر بيه زي N سجما M على SY الكتر بيه بالساوية
+
+160
+00:15:31,170 --> 00:15:32,050
+واحدة
+
+161
+00:15:38,100 --> 00:15:45,240
+الان هنتطلع ال table 6 6 ل 6 8 يعني عندي 6 6 6 7 6
+
+162
+00:15:45,240 --> 00:15:51,460
+8 ال table 6 6 معطيني الحسابات للمدفعات جودمان
+
+163
+00:15:51,460 --> 00:15:57,440
+المدفعات جودمان احنا حكينا جاية بين عندي جاية بين
+
+164
+00:15:57,440 --> 00:16:05,460
+هذا
+
+165
+00:16:05,460 --> 00:16:13,550
+ال yield ال yieldline هنا عندي sy هنا sut هنا sy
+
+166
+00:16:13,550 --> 00:16:25,170
+هنا sa وهذا ال load line ال load line وهذا ال
+
+167
+00:16:25,170 --> 00:16:29,310
+critical ال
+
+168
+00:16:29,310 --> 00:16:32,930
+critical load
+
+169
+00:16:32,930 --> 00:16:35,030
+line
+
+170
+00:16:47,620 --> 00:16:54,620
+هذا الخط ال filler line معرفه ليه علاقة اللي هي SA
+
+171
+00:16:54,620 --> 00:17:09,560
+على SE زائد SM على SUT بساوي واحد وال
+
+172
+00:17:09,560 --> 00:17:13,040
+yield line هذا معدلته SA
+
+173
+00:17:14,520 --> 00:17:25,380
+على SY زاد SM على SY بساوي واحد وهذا ال load line
+
+174
+00:17:25,380 --> 00:17:39,860
+هذا sigma M وهذا sigma A النقطة قاطعة دول SM
+
+175
+00:17:43,530 --> 00:17:51,350
+و S A و
+
+176
+00:17:51,350 --> 00:17:55,150
+ال slope بتاعها ده اللي هو ال line اللي هو R R
+
+177
+00:17:55,150 --> 00:18:12,210
+بالسواء S M على S A S A على S M بالسواء
+
+178
+00:18:12,210 --> 00:18:12,890
+سجما A
+
+179
+00:18:17,590 --> 00:18:22,790
+السطر الأول من الجدول يوجد نقطة التقاطع load line
+
+180
+00:18:22,790 --> 00:18:29,770
+مع fatigue line يعني النقطة هذه السطر الأول هذا
+
+181
+00:18:29,770 --> 00:18:35,650
+يوجد نقطة التقاطع load line مع fatigue line اللي
+
+182
+00:18:35,650 --> 00:18:43,950
+هي بيحسبلي ال S A بستوار R S E S U Tزاد R S U T ال
+
+183
+00:18:43,950 --> 00:18:47,610
+S A بيسوا R S E S U T على R S U T زاد S E و ال S M
+
+184
+00:18:47,610 --> 00:18:55,190
+بيسوا S E على R السطر التاني بوجود التقاطع ال load
+
+185
+00:18:55,190 --> 00:19:05,010
+line مع ال yield line هذه نقطة واحد هذه واحد اتنين
+
+186
+00:19:05,010 --> 00:19:07,990
+اللي هي النقطة هذه
+
+187
+00:19:11,180 --> 00:19:16,500
+معناته نقطة اتنين بتمثلي
+
+188
+00:19:16,500 --> 00:19:25,060
+تقاطع ال load line مع ال yield line السطر
+
+189
+00:19:25,060 --> 00:19:37,080
+التالت بوجود تقاطع ال fatigue line مع ال yield
+
+190
+00:19:37,080 --> 00:19:39,120
+line يعني هذه النقطة
+
+191
+00:19:45,160 --> 00:19:51,440
+معناه في سطر التالت بوجود تقاطع ال fatigue line مع
+
+192
+00:19:51,440 --> 00:19:57,300
+ال yield line و ال factor of safety enough هيكون
+
+193
+00:19:57,300 --> 00:20:00,940
+موضوع العلاقة هذه enough بس واحد على sigma a زاد
+
+194
+00:20:00,940 --> 00:20:05,360
+.. واحد على sigma a على s e زاد sigma m على s u t
+
+195
+00:20:05,360 --> 00:20:10,880
+طبعا
+
+196
+00:20:12,050 --> 00:20:16,530
+الجدول هذا مكرر لل other design theories يعني مكرر
+
+197
+00:20:16,530 --> 00:20:21,950
+بالنسبة لإيش لgerber fatigue theory و ال asthma
+
+198
+00:20:21,950 --> 00:20:23,470
+elliptic fatigue theory
+
+199
+00:20:52,130 --> 00:20:59,230
+طيب نشوف ال example a واحد و نص انش diameter bar
+
+200
+00:20:59,230 --> 00:21:08,070
+عند القطر يعني دي بس واحد و نص انش has been
+
+201
+00:21:08,070 --> 00:21:15,610
+machined from
+
+202
+00:21:15,610 --> 00:21:23,380
+an AISIالف و خمسين cold drawn bar ال material عشرة
+
+203
+00:21:23,380 --> 00:21:30,600
+خمسين cold drawn steel this
+
+204
+00:21:30,600 --> 00:21:35,380
+part is هذا ال part is to withstand a fluctuating
+
+205
+00:21:35,380 --> 00:21:40,300
+tensile load varying from zero to sixteen kilo
+
+206
+00:21:40,300 --> 00:21:46,280
+pound يعني هيكون عليه ال F minimum
+
+207
+00:21:48,010 --> 00:21:56,270
+بساوي zero وال F maximum بساوي ستاشر kilo pound
+
+208
+00:22:05,180 --> 00:22:08,720
+because of the ends and fillet radius a fatigue
+
+209
+00:22:08,720 --> 00:22:12,560
+stress concentration factor KF يعني هو من الأطراف
+
+210
+00:22:12,560 --> 00:22:15,140
+واضح أن في عنده stress concentration فأخد فين
+
+211
+00:22:15,140 --> 00:22:18,720
+اعتبار fatigue stress concentration factor KF
+
+212
+00:22:18,720 --> 00:22:26,920
+بيساوي واحد point تمانية خمسة for عشر أو ستة or
+
+213
+00:22:26,920 --> 00:22:34,700
+larger lifefind S A and S M and the factor of
+
+214
+00:22:34,700 --> 00:22:40,160
+safety guarding against fatigue and first cycle
+
+215
+00:22:40,160 --> 00:22:44,060
+yielding using Gerber fatigue line Gerber fatigue
+
+216
+00:22:44,060 --> 00:22:54,700
+line طيب ال Gerber fatigue line جايبين
+
+217
+00:22:57,080 --> 00:23:05,940
+عند ال S U T عند هنا S Y عند هنا S E و جاي non
+
+218
+00:23:05,940 --> 00:23:10,000
+-linear و
+
+219
+00:23:10,000 --> 00:23:15,340
+ال S Y هذا
+
+220
+00:23:15,340 --> 00:23:17,840
+ال yield هذا Gerber
+
+221
+00:23:21,920 --> 00:23:26,200
+أول شي انا ال steel عندى عشرة خمسين و انا اتوح
+
+222
+00:23:26,200 --> 00:23:47,160
+اروح على appendix A عشرين appendix
+
+223
+00:23:47,160 --> 00:23:50,860
+A عشرين و الحديد الف و خمسين
+
+224
+00:23:54,850 --> 00:24:02,050
+cauldron اللي عندنا اللي هو ال SUT بتاعته مية هذه
+
+225
+00:24:02,050 --> 00:24:08,530
+الف و خمسين ال
+
+226
+00:24:08,530 --> 00:24:15,330
+SUT بتاعته سوميت
+
+227
+00:24:15,330 --> 00:24:21,770
+كيلو pound per square inch و ال SY بالساوي
+
+228
+00:24:23,900 --> 00:24:28,780
+اربعة تمانين كيلو
+
+229
+00:24:28,780 --> 00:24:41,360
+pound per square inch هذه A عشرين طيب
+
+230
+00:25:10,450 --> 00:25:17,310
+طيب هو معطيني ان ال .. ال .. ال .. ال .. ال .. ال
+
+231
+00:25:17,310 --> 00:25:17,470
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+232
+00:25:17,470 --> 00:25:17,530
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+233
+00:25:17,530 --> 00:25:17,570
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+234
+00:25:17,570 --> 00:25:17,870
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+235
+00:25:17,870 --> 00:25:19,350
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+236
+00:25:19,350 --> 00:25:19,550
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+237
+00:25:19,550 --> 00:25:21,070
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+238
+00:25:21,070 --> 00:25:26,150
+.. ال .. ال .. ال .. ال ..
+
+239
+00:25:26,150 --> 00:25:26,170
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+240
+00:25:26,170 --> 00:25:29,470
+.. ال ..
+
+241
+00:25:29,470 --> 00:25:34,470
+ال .. ال ..
+
+242
+00:25:34,470 --> 00:25:35,990
+ال
+
+243
+00:25:44,270 --> 00:25:51,030
+الان ال .. بار قطره الان ال stress sigma بشكل عام
+
+244
+00:25:51,030 --> 00:25:57,490
+sigma alternating بالساوية F alternating على ال A
+
+245
+00:25:57,490 --> 00:26:07,110
+بالساوية أربعة F alternating على باي D تربيع طبعا
+
+246
+00:26:07,110 --> 00:26:14,900
+هتساوي ال sigma M برضه في الحالة هذه هتساوياربع في
+
+247
+00:26:14,900 --> 00:26:27,100
+تمانية kilo pound على by في واحد و نص تربية يعني
+
+248
+00:26:27,100 --> 00:26:35,700
+هكون انه تلاتين تقسم تلاتة point واحد اربع تقسم
+
+249
+00:26:35,700 --> 00:26:40,360
+واحد و نص تقسم واحد و نص يساوي
+
+250
+00:26:42,670 --> 00:26:49,410
+بطلع أربعة point خمسة تلاتة أربعة point خمسة تلاتة
+
+251
+00:26:49,410 --> 00:26:53,490
+kilo pound per square inch هذا ال sigma main و
+
+252
+00:26:53,490 --> 00:26:54,110
+sigma alternative
+
+253
+00:27:13,000 --> 00:27:18,960
+الان احنا هاي الرصبة عندى ال S U T مية ال S U T
+
+254
+00:27:18,960 --> 00:27:28,000
+مية هده مية هد ال S U T و ال S Y أربعة و تمانين و
+
+255
+00:27:28,000 --> 00:27:31,500
+ال S E طبعا .. و اللي هين عندى هين اربعة و تمانين
+
+256
+00:27:31,500 --> 00:27:37,080
+ال S Y مطلوب احسب ايش ال S E فى الأول ده احسب ال S
+
+257
+00:27:37,080 --> 00:27:44,780
+Eالـ prime هستوى نص ال SUT هتكون نص في مية هتكون
+
+258
+00:27:44,780 --> 00:27:50,160
+خمسين كيلو pound per square inch الان هو حكى لي
+
+259
+00:27:50,160 --> 00:27:53,360
+machined معناه بتحسب ال K A بتعمل modification
+
+260
+00:27:53,360 --> 00:28:04,360
+factors K A ال
+
+261
+00:28:04,360 --> 00:28:18,940
+K Aالـ K A هو A S U T أُس B هو Machined هتكون
+
+262
+00:28:18,940 --> 00:28:26,400
+ال A اتنين point سبعة اتنين point سبعة في مية ال B
+
+263
+00:28:26,400 --> 00:28:30,120
+هتكون minus point اتنين ستة خمسة
+
+264
+00:28:38,450 --> 00:28:43,930
+مية اقصى minus يساوي
+
+265
+00:28:43,930 --> 00:28:50,670
+في اتنين bond سبعة تطلع bond سبعة تسعة تمانية bond
+
+266
+00:28:50,670 --> 00:29:02,290
+سبعة تسعة تمانية هذه ال K A ال size factor ال KB
+
+267
+00:29:07,490 --> 00:29:10,350
+في حالة axial loading انا عندي axial loading KB
+
+268
+00:29:10,350 --> 00:29:21,570
+هتكون تساوي واحد ال
+
+269
+00:29:21,570 --> 00:29:32,670
+KC for axial loading KC سابون تمانية خمسة ال KD و
+
+270
+00:29:32,670 --> 00:29:41,460
+ال KE معناته هتكون سوا KDبساوي KE بساوي واحد ومنها
+
+271
+00:29:41,460 --> 00:29:51,220
+بحسب ال SE هتكون KA اللي هي bond 7 تسعة تمانية في
+
+272
+00:29:51,220 --> 00:29:56,280
+KB واحد في KC bond تمانية خمسة في ال SE prime اللي
+
+273
+00:29:56,280 --> 00:29:58,040
+هي خمسين
+
+274
+00:30:01,240 --> 00:30:08,180
+بونت سبعة تسعة تمانية في بونت تمانية خمسة في خمسين
+
+275
+00:30:08,180 --> 00:30:13,360
+تتطلع تلاتة ثلاثين بونت تسعة اتنين تلاتة ثلاثين
+
+276
+00:30:13,360 --> 00:30:19,300
+بونت تسعة اتنين كيلو pound per square inch هذا ال
+
+277
+00:30:19,300 --> 00:30:19,720
+S
+
+278
+00:30:53,520 --> 00:30:58,140
+الان سيجمه مين هذه nominal وهذه عشان nominal يعني
+
+279
+00:30:58,140 --> 00:31:04,760
+سيجمه مين سوى سيجمه A حسب سوى KFفي ال sigma ايه
+
+280
+00:31:04,760 --> 00:31:08,760
+كيف معطني واحد point تمانية خمسة في أربع point
+
+281
+00:31:08,760 --> 00:31:13,780
+خمسة تلاتة عندي
+
+282
+00:31:13,780 --> 00:31:18,380
+واحد point تمانية خمسة في أربع point خمسة تلاتة
+
+283
+00:31:18,380 --> 00:31:23,560
+بطلع تمانية point تلاتة تمانية تمانية point تلاتة
+
+284
+00:31:23,560 --> 00:31:28,000
+تمانية kilo
+
+285
+00:31:28,000 --> 00:31:33,510
+pound per square inch معناه يقول عندي هناتمانية
+
+286
+00:31:33,510 --> 00:31:39,830
+point تلاتة تمانية اللي هي هذه ال sigma mean وعندي
+
+287
+00:31:39,830 --> 00:31:43,270
+هي تمانية point تلاتة تمانية اللي هي sigma
+
+288
+00:31:43,270 --> 00:31:52,550
+alternating معناته هذا هو ال load line تبعي هذا ال
+
+289
+00:31:52,550 --> 00:31:58,430
+load line تبعي لأن
+
+290
+00:31:58,430 --> 00:32:00,970
+عشان اوجد ال fatigue factor of safety
+
+291
+00:32:10,730 --> 00:32:17,850
+هذه ستكون SM وهذه SA
+
+292
+00:32:17,850 --> 00:32:26,790
+SM و SA واضح سلوب الخط هذا ال R بيساوي احد لأن
+
+293
+00:32:26,790 --> 00:32:29,330
+sigma M بيساوي sigma ال alternating معنى السلوب
+
+294
+00:32:29,330 --> 00:32:35,150
+ايش بيساوي واحد احنا بدنا جيربار criteria
+
+295
+00:32:40,330 --> 00:32:47,430
+معنى طبيعي احنا هنا هتكون عندى S A S A S
+
+296
+00:32:47,430 --> 00:32:59,590
+A هتكون تساوي تابع ست سابع هتكون R Square S U T
+
+297
+00:32:59,590 --> 00:33:11,310
+Square على اتنين S E في minus واحدزاد جزر التربيع
+
+298
+00:33:11,310 --> 00:33:26,990
+لواحد زاد اتنين SE على RSUT لكل
+
+299
+00:33:26,990 --> 00:33:33,590
+تربيع يعني انا هاكون عندى واحد في ال SUT اللي هي
+
+300
+00:33:33,590 --> 00:33:37,170
+مية في
+
+301
+00:33:37,170 --> 00:33:50,090
+ميةتربيع على اتنين في SE تربيع
+
+302
+00:33:50,090 --> 00:33:53,250
+على اتنين في SE تربيع على اتنين في SE تربيع على
+
+303
+00:33:53,250 --> 00:33:54,490
+اتنين في SE تربيع على اتنين في SE تربيع على اتنين
+
+304
+00:33:54,490 --> 00:33:54,530
+تربيع على اتنين في SE تربيع على اتنين في SE تربيع
+
+305
+00:33:54,530 --> 00:33:55,830
+على اتنين في SE تربيع على اتنين في SE تربيع على
+
+306
+00:33:55,830 --> 00:33:56,470
+اتنين في SE تربيع على اتنين في SE تربيع على اتنين
+
+307
+00:33:56,470 --> 00:33:56,890
+في SE تربيع على اتنين في SE تربيع على اتنين في SE
+
+308
+00:33:56,890 --> 00:34:00,370
+تربيع على اتنين في SE تربيع على اتنين في SE تربيع
+
+309
+00:34:00,370 --> 00:34:05,430
+على اتنين في SE تربيع
+
+310
+00:34:09,030 --> 00:34:17,730
+هتطلع ال S A هندى ال S A هتطلع تلاتين بون سبعة
+
+311
+00:34:17,730 --> 00:34:22,450
+كيلو
+
+312
+00:34:22,450 --> 00:34:26,530
+pound per square inch معناه ان ال fatigue factor
+
+313
+00:34:26,530 --> 00:34:34,970
+of safety ال un fatigue هيكون ساوى S A على سيجما A
+
+314
+00:34:35,880 --> 00:34:41,640
+الاس ايه اللي هي عند ال تلاتين point سبعة على سجن
+
+315
+00:34:41,640 --> 00:34:52,440
+ايه اللي هي تمانية point تلاتة تمانية تلاتين
+
+316
+00:34:52,440 --> 00:34:58,160
+point سبعة تقصير تمانية point تلات تمانية يساوي
+
+317
+00:35:00,510 --> 00:35:19,690
+تطلع تلاتة point ستة ستة تلاتة point ستة ستة عشان
+
+318
+00:35:19,690 --> 00:35:25,230
+احسب الny لازم هذا نقطة واحد لازم اوجد احتثيات
+
+319
+00:35:25,230 --> 00:35:32,990
+النقطة اتنين خدني ضحك هاداسمه SM تاعة ال yield
+
+320
+00:35:32,990 --> 00:35:41,590
+وهذه SM SA تاعة ال yield وهذا ال load line ماله
+
+321
+00:35:41,590 --> 00:35:45,890
+خمس واربعين درجة ومعناته ال R بالساوية واحد نرجع
+
+322
+00:35:45,890 --> 00:35:56,630
+للجدول Gerber اللي هو ال SA هتكون تساوية ال SA
+
+323
+00:35:58,900 --> 00:36:06,900
+هتكون R في S Y على واحد زائد R يعني هتكون واحد في
+
+324
+00:36:06,900 --> 00:36:10,980
+أربعة و تمانين على واحد زائد واحد يعني اربعة و
+
+325
+00:36:10,980 --> 00:36:14,740
+تمانين على اتنين اتنين و اربعين kilo pound per
+
+326
+00:36:14,740 --> 00:36:19,680
+square inch معنى
+
+327
+00:36:19,680 --> 00:36:20,180
+ال NY
+
+328
+00:36:23,220 --> 00:36:28,520
+هيكون ساوى اللي هو S A على Sigma A اللي هي اتنين و
+
+329
+00:36:28,520 --> 00:36:37,260
+اربعين على تمانية point تلاتة تمانية اتنين
+
+330
+00:36:37,260 --> 00:36:44,040
+و اربعين تقسيم تمانية point تلات تمانية بيطلع خمسة
+
+331
+00:36:44,040 --> 00:36:45,860
+point او واحد خمسة
+
+332
+00:36:49,880 --> 00:36:52,760
+واضح ال factor of safety في حالة ال yielding أعلى
+
+333
+00:36:52,760 --> 00:36:56,420
+من ال factor of safety في حالة الفتيك مانعته ال
+
+334
+00:36:56,420 --> 00:37:01,820
+potential for fatigue failure أعلى من ال potential
+
+335
+00:37:01,820 --> 00:37:04,720
+for yielding يعني هيصيرله fatigue failure before
+
+336
+00:37:04,720 --> 00:37:11,600
+it yields طبعا
+
+337
+00:37:11,600 --> 00:37:14,800
+الفرع التاني نفس الفرع الأول بس هستخدم نظري تاني
+
+338
+00:37:14,800 --> 00:37:17,800
+ازمة elliptic fatigue line نفس الحال تماما
+
+339
+00:37:20,730 --> 00:37:26,730
+محاضرة الجاية بن .. بنكمل بتكون ان شاء الله اخر
+
+340
+00:37:26,730 --> 00:37:31,590
+محاضرة في chapter 6 اللي هو fatigue criteria for
+
+341
+00:37:31,590 --> 00:37:33,930
+brittle materials اعطيكوا العفو
+