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"probability": 0.845703125}, {"start": 408.66, "end": 408.9, "word": " فيها", "probability": 0.916748046875}, {"start": 408.9, "end": 409.3, "word": " علاقة", "probability": 0.9814453125}, {"start": 409.3, "end": 409.78, "word": " و", "probability": 0.96923828125}, {"start": 409.78, "end": 409.98, "word": " على", "probability": 0.284423828125}, {"start": 409.98, "end": 410.26, "word": " هذا", "probability": 0.72412109375}, {"start": 410.26, "end": 410.86, "word": " الأساس", "probability": 0.96484375}], "temperature": 1.0}, {"id": 15, "seek": 43681, "start": 411.23, "end": 436.81, "text": "يقرر ايش اللي بيعمله احنا لان هنا لما يكون العلاقة طبيعية نسميها positive correlation لما نكون عكسية نسميها negative correlation لما مايوجهش فيه اي نوع من العلاقة نسميها non-correlation نرجع مرة تانية بس scatter plot قلنا عبارة عن ايش؟", "tokens": [1829, 4587, 2288, 2288, 1975, 1829, 8592, 13672, 1829, 4724, 1829, 25957, 1211, 3224, 1975, 5016, 8315, 5296, 7649, 34105, 5296, 15042, 7251, 30544, 18863, 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"end": 462.71, "word": " ال", "probability": 0.64208984375}, {"start": 462.71, "end": 462.99, "word": " X", "probability": 0.55712890625}, {"start": 462.99, "end": 463.35, "word": " أو", "probability": 0.935546875}, {"start": 463.35, "end": 463.75, "word": " ال", "probability": 0.98388671875}, {"start": 463.75, "end": 464.09, "word": " Y", "probability": 0.958984375}], "temperature": 1.0}, {"id": 17, "seek": 49329, "start": 464.43, "end": 493.29, "text": "The position of each point on the horizontal axis is determined by one variable and on the vertical axis by another variable هذي المثال اللي شفناه عبارة عن ال core عبارة عن plug ده علاقة ال height تبع الأشخاص مع ال weight الكل عارف أن ال weight و ال height متناسبوا مع بعض", "tokens": [2278, 2535, 295, 1184, 935, 322, 264, 12750, 10298, 307, 9540, 538, 472, 7006, 293, 322, 264, 9429, 10298, 538, 1071, 7006, 8032, 8848, 1829, 9673, 12984, 6027, 13672, 1829, 13412, 5172, 8315, 3224, 6225, 3555, 9640, 3660, 18871, 2423, 4965, 6225, 3555, 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479.23, "word": " plug", "probability": 0.361328125}, {"start": 479.23, "end": 479.73, "word": " ده", "probability": 0.61279296875}, {"start": 479.73, "end": 480.65, "word": " علاقة", "probability": 0.9723307291666666}, {"start": 480.65, "end": 481.03, "word": " ال", "probability": 0.93701171875}, {"start": 481.03, "end": 482.47, "word": " height", "probability": 0.8046875}, {"start": 482.47, "end": 483.91, "word": " تبع", "probability": 0.7767740885416666}, {"start": 483.91, "end": 484.49, "word": " الأشخاص", "probability": 0.9810791015625}, {"start": 484.49, "end": 484.85, "word": " مع", "probability": 0.978515625}, {"start": 484.85, "end": 485.01, "word": " ال", "probability": 0.98291015625}, {"start": 485.01, "end": 485.33, "word": " weight", "probability": 0.9560546875}, {"start": 485.33, "end": 488.89, "word": " الكل", "probability": 0.49957275390625}, {"start": 488.89, "end": 490.25, "word": " عارف", "probability": 0.9033203125}, {"start": 490.25, "end": 490.43, "word": " أن", 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"probability": 0.6407470703125}, {"start": 1582.33, "end": 1582.71, "word": " ضايل", "probability": 0.7981770833333334}, {"start": 1582.71, "end": 1583.01, "word": " من", "probability": 0.958984375}, {"start": 1583.01, "end": 1584.75, "word": " 17،", "probability": 0.6123046875}, {"start": 1584.75, "end": 1584.93, "word": " عشان", "probability": 0.6599934895833334}, {"start": 1584.93, "end": 1585.31, "word": " أعطيكم", "probability": 0.8822265625}, {"start": 1585.31, "end": 1585.73, "word": " ملاحظة", "probability": 0.661083984375}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 1586.991, "duration_after_vad": 1504.2518749999979}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/2BhZ2dcbh8U.srt b/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/2BhZ2dcbh8U.srt
new file mode 100644
index 0000000000000000000000000000000000000000..dc833079275c295d68f1f792a48a959374ab2a5f
--- /dev/null
+++ b/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/2BhZ2dcbh8U.srt
@@ -0,0 +1,1946 @@
+1
+00:00:20,860 --> 00:00:23,240
+طيب ماشي، بسم الله الرحمن الرحيم، اليوم إن شاء الله
+
+2
+00:00:23,240 --> 00:00:30,040
+بدنا نكمل قدر أكبر في الموضوع اللي هو الـ fuzzy
+
+3
+00:00:30,040 --> 00:00:33,100
+expert systems، كنا في المحاضرة اللي فاتت دوبنا
+
+4
+00:00:33,100 --> 00:00:38,420
+بدينا نحكي عن اللي هو المفاهيم الأولى لـ الـ fuzzy
+
+5
+00:00:38,420 --> 00:00:43,020
+expert systems، وحكينا عن الـ fuzzy rules. الآن
+
+6
+00:00:43,020 --> 00:00:46,020
+بدي أرجع شوية على ثبت أنه أبدأ في الموضوع من
+
+7
+00:00:46,020 --> 00:00:50,460
+البداية، والحين نقدر نجمّع كله، المحاضرة هذه إن شاء
+
+8
+00:00:50,460 --> 00:00:54,600
+الله. الموضوع هذا موجود في الـ slides عندكم من lecture
+
+9
+00:00:54,600 --> 00:00:58,760
+رقم أربعة، وفي file ثاني اللي هو lecture رقم خمسة
+
+10
+00:00:58,760 --> 00:01:02,220
+بيكمل الموضوع، دا كالـ lecture رقم خمسة، بيتناول الـ
+
+11
+00:01:02,220 --> 00:01:06,160
+inference. هنا في أربعة، مقدمة بيحكي فيها عن
+
+12
+00:01:06,160 --> 00:01:08,960
+introduction عن الـ fuzzy sets، وبعدين عن الـ
+
+13
+00:01:08,960 --> 00:01:12,440
+linguistic variables، والـ hedges، وبعدين بيحكي
+
+14
+00:01:12,440 --> 00:01:15,720
+operations of fuzzy sets، وبعدين بيصل لـ fuzzy
+
+15
+00:01:15,720 --> 00:01:22,350
+rules. احنا بدنا نحاول نخلص الحكي ونصل لـ fuzzy
+
+16
+00:01:22,350 --> 00:01:25,170
+rules، اللي هو already احنا حكينا في المحاضرة
+
+17
+00:01:25,170 --> 00:01:29,250
+السابقة، علشان نقدر نكمل بعد هيك على الـ inference.
+
+18
+00:01:29,250 --> 00:01:32,350
+ندخل على الـ lecture رقم 5 ونحكي في الـ inference.
+
+19
+00:01:32,350 --> 00:01:37,890
+فأنا الـ introduction أو what is fuzzy thinking، و
+
+20
+00:01:37,890 --> 00:01:42,550
+fuzzy sets، وحتى كمان الـ linguistic values and
+
+21
+00:01:42,550 --> 00:01:49,110
+hedges. أنا حأبدأ من الـ fuzzy sets، وهأحكي
+
+22
+00:01:49,110 --> 00:01:52,070
+الـ linguistic variables على طول، بسرعة، وبعدين
+
+23
+00:01:52,070 --> 00:01:58,690
+الأوّراج الزرقية، هنفلتها، الهجز برا، هنفلتها، ماشي.
+
+24
+00:01:58,690 --> 00:02:03,190
+هنتقل على طول، يعني واحد، اتنين، بعدين تلاتة، وبعدين
+
+25
+00:02:03,190 --> 00:02:07,730
+نكمل على اللي هو الـ slide رقم خمسة، الـ lecture رقم
+
+26
+00:02:07,730 --> 00:02:11,970
+خمسة. كل المفاهيم اللي، آخر كل المفاهيم اللي احنا
+
+27
+00:02:11,970 --> 00:02:16,640
+بنتركها بتكون هي مرت معنا أثناء الحكي، واللي ما مرّش
+
+28
+00:02:16,640 --> 00:02:21,480
+هنرجع له تاني، الـ operations هنرجع لها تاني في الآخر.
+
+29
+00:02:21,480 --> 00:02:28,920
+الكلام هذا، لو قفزنا لسبب ما من slide رقم تسعة
+
+30
+00:02:28,920 --> 00:02:35,320
+إلى تسعة عشر.
+
+31
+00:02:35,320 --> 00:02:41,000
+عشرة، تمام؟ بس قبل عشرة، ربما نلقي نظرة على تسعة.
+
+32
+00:02:43,770 --> 00:02:47,510
+تسعة، تسعة هي دي برضه كمان أنا حكيت فيها في المحاضرة
+
+33
+00:02:47,510 --> 00:02:54,230
+الماضية في الـ boolean logic، عشان احنا دلوقت بنفهم
+
+34
+00:02:54,230 --> 00:02:56,590
+مصطلح الـ fuzzy logic. الـ fuzzy logic هو الـ logic
+
+35
+00:02:56,590 --> 00:03:02,250
+العادي، بس بدل ما يبقى في عندي القيم الـ truth يا إما
+
+36
+00:03:02,250 --> 00:03:06,530
+الـ zero أو one، يا إما true يا إما false، لأ، في عندي
+
+37
+00:03:06,530 --> 00:03:12,490
+تدرج في القيم. الـ boolean logic بقول إما true أو
+
+38
+00:03:12,490 --> 00:03:17,710
+false، إما true أو false، إما ينتمي إلى truth أو
+
+39
+00:03:17,710 --> 00:03:21,350
+ينتمي إلى false. بينما في الـ multivalue، درجة اللي
+
+40
+00:03:21,350 --> 00:03:26,810
+هو اسم آخر للـ fuzzy، بيبدأ في أنه يتدرج في درجة
+
+41
+00:03:26,810 --> 00:03:31,740
+الحقيقة، يعني هي true ممكن مش يا true يا false، يا
+
+42
+00:03:31,740 --> 00:03:34,200
+ممكن تبقى تسعين في المئة، وممكن تبقى سبعين في
+
+43
+00:03:34,200 --> 00:03:40,720
+المئة، وممكن تبقى بنسب متفاوتة. فهي المقصود بإنّه، أو
+
+44
+00:03:40,720 --> 00:03:44,000
+التمييز ما بين الـ boolean logic وما بين الـ
+
+45
+00:03:44,000 --> 00:03:49,780
+multivalued أو الـ fuzzy logic، هذا
+
+46
+00:03:49,780 --> 00:03:53,920
+الكلام بيدخلنا على مفهوم الـ fuzzy set. الـ fuzzy set
+
+47
+00:03:53,920 --> 00:03:58,260
+لما أنا قلت هنا إنّه أنا عندي الحقيقة يا إما بتكون
+
+48
+00:03:58,260 --> 00:04:01,760
+true يا إما بتكون false، معنى ذلك أنا ما أقدر أقول
+
+49
+00:04:01,760 --> 00:04:05,000
+الحقائق، أو الـ...الـ...الـ...الـ...الـ...الـ
+
+50
+00:04:05,000 --> 00:04:08,720
+assertions، يعني الإدعاء، يا ما بكون ينتمي إلى مجموعة
+
+51
+00:04:08,720 --> 00:04:13,660
+الـ true، يا ما بينتمي إلى مجموعة الـ false. وانتماؤه
+
+52
+00:04:13,660 --> 00:04:17,460
+هنا معناه إن هو مش منتمي للطرف الآخر، إذًا منتمي للـ
+
+53
+00:04:17,460 --> 00:04:20,890
+true، هو حتمًا لا ينتمي إلى الـ false، صح؟ بينما في
+
+54
+00:04:20,890 --> 00:04:25,750
+الـ fuzzy، لأ، ممكن يكون هو ينتمي لأكثر من مجموعة، يعني
+
+55
+00:04:25,750 --> 00:04:29,490
+الحقيقة ممكن تبقى منتمية لهذه المجموعة الـ
+
+56
+00:04:29,490 --> 00:04:34,210
+assertions، مجموعة ألف، ومجموعة باء، بدرجات متفاوتة.
+
+57
+00:04:34,210 --> 00:04:37,910
+ماشي. فمفهوم الـ set أصلاً اللي احنا بنعرفه في
+
+58
+00:04:37,910 --> 00:04:42,930
+الرياضيات أصلاً، لكن الآن بدل ما أنا آجي أقول إن
+
+59
+00:04:42,930 --> 00:04:53,580
+فلان ينتمي إلى هاي المجموعة، okay. بدل أن نجيب، بدل ما
+
+60
+00:04:53,580 --> 00:04:57,260
+يكون، أنسى، أنسى الدائرة هذا الـ grey، اعتبر إن أنا في
+
+61
+00:04:57,260 --> 00:05:02,840
+عندك الدائرة السوداء، والخارج اللي هو الأبيض، لأن
+
+62
+00:05:02,840 --> 00:05:10,540
+أي نقطة إما بتكون جوا أو برا، صح؟ فهي إما تنتمي
+
+63
+00:05:10,540 --> 00:05:14,160
+إلى المجموعة أو لا تنتمي إليها. فعندما في الـ fuzzy
+
+64
+00:05:14,160 --> 00:05:17,740
+السادة، احنا لما في عندنا انتماء، وبرضه في كمان
+
+65
+00:05:20,420 --> 00:05:27,340
+على الأطراف في درجات متفاوتة من الانتماء، ولا
+
+66
+00:05:27,340 --> 00:05:30,640
+ينتمي تماماً. لأن مثلاً أنا ممكن أضع في end value
+
+67
+00:05:30,640 --> 00:05:37,280
+يعبر عنّه قيمة على الـ X-axis، الـ value هذا هنا، هذا
+
+68
+00:05:37,280 --> 00:05:42,120
+لا ينتمي إلى المجموعة إطلاقاً، لا ينتمي إلى المجموعة.
+
+69
+00:05:42,120 --> 00:05:47,280
+الفاصلة P2، P2 صغيرة، بقول مثلاً تلاتة، يجعله لا ينتمي
+
+70
+00:05:47,280 --> 00:05:50,840
+بالمرة إلى المجموعة. بينما الـ value هذا، والـ value
+
+71
+00:05:50,840 --> 00:05:54,840
+هذا، هذا الـ value ينتمي تماماً إلى المجموعة، لأن واقِع
+
+72
+00:05:54,840 --> 00:06:00,240
+في الـ range هذا. هذا الـ value هنا ينتمي partially
+
+73
+00:06:00,240 --> 00:06:06,240
+جزئياً إلى المجموعة، نسمّيها مجموعة A. هذا أيضاً كذلك
+
+74
+00:06:06,240 --> 00:06:11,540
+الحالة. أي value هنا ينتمي جزئياً إلى مجموعة A، بينما
+
+75
+00:06:11,540 --> 00:06:18,140
+بعد ذلك الانتماء صفر. فإيش الاختلاف الأهم بين هذا
+
+76
+00:06:18,140 --> 00:06:22,060
+الكلام؟ من بين هذا الكلام، إن هنا boolean، boolean، يا إما
+
+77
+00:06:22,060 --> 00:06:26,360
+ينتمي، يا إما لا ينتمي، قطع، عشان ذلك نسمّيهم crisp
+
+78
+00:06:26,360 --> 00:06:33,740
+...crisp...crisp set، يعني في قطع ثابت بين
+
+79
+00:06:33,740 --> 00:06:38,180
+الناحيتين. بينما في الـ fuzzy set، لأ، ما في قطع فيها،
+
+80
+00:06:38,180 --> 00:06:42,860
+دي نوع من الضبابية، هذه منطقة ضبابية اللي ممكن تقع
+
+81
+00:06:42,860 --> 00:06:47,250
+فيها بعض الـ...بعض العناصر. وفي المنطقة الضبابية،
+
+82
+00:06:47,250 --> 00:06:50,910
+انتماء العنصر اللي واقع في المنطقة الضبابية بيبقى
+
+83
+00:06:50,910 --> 00:06:57,650
+نسبي، partial، جزئي، تمام؟ عشان أيه كلمة نسميه؟
+
+84
+00:06:57,650 --> 00:07:00,950
+Fuzziness. وهذا fuzziness، عشان كلمة fuzzy أصلاً جايه من
+
+85
+00:07:00,950 --> 00:07:04,810
+...لما أنا أشرح بالنظر، أنا بشوفكوا fuzzy، بشوفكوا
+
+86
+00:07:04,810 --> 00:07:08,490
+مغبّش، ضبابي، يعني ما فيش شيء وضوح للرؤية، ماهيش
+
+87
+00:07:08,490 --> 00:07:13,270
+crisp. Okay، فأنا الآن بس فزّعت لهذا الـ slide بس
+
+88
+00:07:13,270 --> 00:07:19,930
+عشان أوضح مفهوم الـ fuzzy set والـ crisp set.
+
+89
+00:07:19,930 --> 00:07:23,690
+واتفقنا إنّه، إنّه مفهوم الـ set هو هو، بس الآن
+
+90
+00:07:23,690 --> 00:07:28,150
+اختلفنا، وأضفنا عليه مفهوم الضبابية، عشان يكون صار
+
+91
+00:07:28,150 --> 00:07:34,890
+fuzzy set. فهو
+
+92
+00:07:34,890 --> 00:07:40,080
+مثال على ذلك، إنّه أنا عندي مثال، طول، مثلاً الطول.
+
+93
+00:07:40,080 --> 00:07:44,380
+أنا لدي أشخاص، وكلّهم راح أقول طولهم بالسنتيمتر، 180،
+
+94
+00:07:44,380 --> 00:07:48,040
+و185، هذا 190، 192، الآن لو
+
+95
+00:07:48,040 --> 00:07:55,420
+أنا بدي أصرّفهم إلى two sets، crisp sets، باجي بحط خط
+
+96
+00:07:55,420 --> 00:07:59,580
+معين، دعيني أقول مثلاً 180، اللي أعلى من 180 هذا
+
+97
+00:07:59,580 --> 00:08:07,380
+بسمّيه أو بقول عنه إيش؟ طويل، واللي أقل من 180 بقول
+
+98
+00:08:07,380 --> 00:08:12,520
+عنه إيش؟ not tall، ممكن أسمّيه short، بس هو إذا ما كانش
+
+99
+00:08:12,520 --> 00:08:15,700
+tall، مش ضروري يبقى short، ممكن يبقى متوسط، بس أنا بدي
+
+100
+00:08:15,700 --> 00:08:20,020
+أقول tall و not tall. هذا إيش؟ هذا لو أنا بانظر لو
+
+101
+00:08:20,020 --> 00:08:25,520
+أنا بدي أرسمها، ملا إيش؟ two crisp sets، أو بدي
+
+102
+00:08:25,520 --> 00:08:31,290
+أتخيّل الـ tall على إن هو الـ set، ماشي، وحدوده من 180
+
+103
+00:08:31,290 --> 00:08:36,850
+إلى 250، في المفهوم. فأي أو لهند، مثلاً أقول 250.
+
+104
+00:08:36,850 --> 00:08:41,970
+أي حد في هذا الـ range هو tall، أي حد خارج هذا الـ
+
+105
+00:08:41,970 --> 00:08:46,370
+range هو مش tall، إيش وصِفه، مش قضية الحين. المهم إنّه
+
+106
+00:08:46,370 --> 00:08:51,590
+أنا حاطط حدود crisp للمجموعة، حدود واضحة
+
+107
+00:08:51,590 --> 00:08:55,590
+دقيقة للمجموعة. بينما في الـ fuzzy، لأ، في الـ fuzzy أنا بقول
+
+108
+00:08:55,590 --> 00:09:03,440
+tall، كلهم tall، ولكن بنسب متفاوتة. هذا الـ range،
+
+109
+00:09:03,440 --> 00:09:10,100
+الراجل 0% طول، الـ 152 هذه أنا بأعتبرها إنّه لا تنتمي
+
+110
+00:09:10,100 --> 00:09:14,720
+إلى الطول، بينما هذا 1%، هذا كل ما زاد، كل ما زاد طول
+
+111
+00:09:14,720 --> 00:09:20,460
+الشخص، آه، بيزيد درجة انتمائه إلى من؟ إلى الطول. أتخيّل
+
+112
+00:09:20,460 --> 00:09:24,460
+برضه كمان الأكتر من 208 هيبقى برضه كمان 100% طول.
+
+113
+00:09:25,010 --> 00:09:30,290
+فواضح الـ...واضح الفكرة، لأن هذا...هذا بيسمّى إيه؟
+
+114
+00:09:30,290 --> 00:09:38,590
+إيش؟ degree of...إيه؟ إيش؟ of...إيه؟ of membership.
+
+115
+00:09:38,590 --> 00:09:46,110
+درجة عضويته أو انتمائه إلى إيش؟
+
+116
+00:09:48,960 --> 00:09:51,760
+للمجموعة اللي هي الـ fuzzy، المجموعة الـ fuzzy.
+
+117
+00:09:51,760 --> 00:09:54,760
+المجموعة الـ fuzzy بنعطيها اسم، اللي هو هنا في هذا
+
+118
+00:09:54,760 --> 00:09:58,100
+المثال اللي هو tall. tall هذا هو اسم المجموعة، وهذا
+
+119
+00:09:58,100 --> 00:10:05,140
+الشخص، درجة انتمائه إلى هذا...ده مجموعة الطول، 98%.
+
+120
+00:10:05,140 --> 00:10:11,600
+فهذا الكلام بتعبّر عنه بالشكل
+
+121
+00:10:11,600 --> 00:10:15,560
+هذا، أو بالـ notation هذا.
+
+122
+00:10:18,790 --> 00:10:28,570
+أنا في عندي set، الـ
+
+123
+00:10:28,570 --> 00:10:33,250
+A، وفي عندي X capital، هذه اللي هي كافة
+
+124
+00:10:33,250 --> 00:10:43,070
+الاحتمالات الممكنة، لـ X small، اللي هي، ليش من
+
+125
+00:10:43,070 --> 00:10:46,470
+كده لكده، أقول مثلاً طول الإنسان، أطول، وممكن يكون
+
+126
+00:10:46,470 --> 00:10:52,460
+أقل من مئة سنتيمتر، ما أعرفش. أعتبر إنّه الـ...الـ...الـ X
+
+127
+00:10:52,460 --> 00:10:58,460
+قيم محددة، تروح من مئة إلى ثلاثمئة، أقل فيه، المهم
+
+128
+00:10:58,460 --> 00:11:03,760
+احنا الـ X capital، capital، يعني كإنّه إيش؟
+
+129
+00:11:03,760 --> 00:11:06,880
+بنتحكي عن set، هي في حد ذاتها set، مجموعة القيم
+
+130
+00:11:06,880 --> 00:11:14,500
+الممكنة للمتغير X، اسمه لهذا، فالـ
+
+131
+00:11:14,500 --> 00:11:16,240
+membership بتاعت X
+
+132
+00:11:19,220 --> 00:11:26,180
+بهذه، أي المتغير في المجموعة A هتكون إما zero أو one.
+
+133
+00:11:26,180 --> 00:11:35,160
+هذا إذا كان المجموعة A إيش؟ crisp، صح؟ بينما في حالة
+
+134
+00:11:35,160 --> 00:11:41,780
+ما يكون في
+
+135
+00:11:41,780 --> 00:11:48,140
+حالة ما يكون الـ A fuzzy، فالقيم
+
+136
+00:11:50,120 --> 00:11:56,200
+μ هذه هي عبارة عن الـ membership value بتاع
+
+137
+00:11:56,200 --> 00:12:02,480
+المتغير X في المجموعة A. هذا الكلام هيكون إما واحد
+
+138
+00:12:02,480 --> 00:12:08,740
+أو زيرو، أو شيء ما بين الزيرو والواحد،
+
+139
+00:12:08,740 --> 00:12:15,760
+أكبر من زيرو و less than one، صح؟ فإذا كانت if X is
+
+140
+00:12:15,760 --> 00:12:21,460
+totally in A، إذا متغير هذا، إذا متغير X، قيمة واقعة
+
+141
+00:12:21,460 --> 00:12:26,360
+جوا المجموعة A، فبكون الـ degree of membership
+
+142
+00:12:26,360 --> 00:12:32,540
+بتاعته هي إيش؟ one. وإذا هو totally، إذا totally not
+
+143
+00:12:32,540 --> 00:12:36,340
+in A، فالـ degree of membership بتاعته إيش؟ Zero. وإلّا
+
+144
+00:12:36,340 --> 00:12:40,960
+بيكون إيش؟ القيمة تتراوح من الـ zero للواحد، if it is
+
+145
+00:12:40,960 --> 00:12:46,460
+partially in it. القيمة تتراوح من الـ zero للواحد، if
+
+146
+00:12:46,460 --> 00:12:51,440
+it is partially in it. القيمة
+
+147
+00:12:51,440 --> 00:12:54,000
+تتراوح من الـ zero للواحد، if it is partially in it.
+
+148
+00:12:54,000 --> 00:12:55,080
+القيمة تتراوح من الـ zero للواحد، if it is partially
+
+149
+00:12:55,080 --> 00:12:56,880
+in it. القيمة تتراوح من الـ zero للواحد، if it is
+
+150
+00:12:56,880 --> 00:12:59,700
+partially in it. القيمة تتراوح من الـ zero للواحد، if
+
+151
+00:12:59,700 --> 00:13:00,440
+it is partially in it. القيمة تتراوح من الـ zero
+
+152
+00:13:00,440 --> 00:13:01,880
+الواحد، if it is partially in it. القيمة تتراوح من
+
+153
+00:13:01,880 --> 00:13:03,440
+الـ zero للواحد، if it is partially in it. القيمة
+
+154
+00:13:03,440 --> 00:13:03,680
+تتراوح من الـ zero للواحد، if it is partially in it.
+
+155
+00:13:03,680 --> 00:13:04,820
+in it. القيمة تتراوح من الـ zero للواحد. هذه الـ
+
+156
+00:13:04,820 --> 00:13:07,360
+notation هي الصيغة اللي احنا بنستخدمها للتعبير عن
+
+157
+00:13:07,360 --> 00:13:09,780
+الـ membership. والآن فهمنا إيش membership، وفهمنا
+
+158
+00:13:09,780 --> 00:13:13,640
+إيش علاقتها بالـ...بالـ sense، بسمّيها degree of
+
+159
+00:13:13,640 --> 00:13:16,520
+membership، also called membership value. أنا
+
+160
+00:13:16,520 --> 00:13:22,640
+بالعربي هسمّيها درجة انتماء، degree، درجة انتماء، يعني
+
+161
+00:13:22,640 --> 00:13:27,940
+عضويته في هذه المجموعة، تمام. عضويته ماهيش crisp، يا
+
+162
+00:13:27,940 --> 00:13:31,220
+إما هو عضو يا ما مش عضو، لأ، هو عضو ولكن بنسبة
+
+163
+00:13:33,890 --> 00:13:37,290
+الآن طبعاً هذا الكلام بنعمل عمله في الكمبيوتر على
+
+164
+00:13:37,290 --> 00:13:45,130
+شكل values، آه،
+
+165
+00:13:45,130 --> 00:13:54,310
+real values، بس.
+
+166
+00:13:54,310 --> 00:13:59,150
+أهم من ذلك اللي هو إنّ احنا، مفهوم الانتماء، ممكن زي ما
+
+167
+00:13:59,150 --> 00:14:02,550
+قلت قبل في البداية، إنّه ممكن يكون انتمائه لأكثر
+
+168
+00:14:02,550 --> 00:14:06,030
+من المجموعة، في أنا الواحد هو نفس الـ member، ممكن
+
+169
+00:14:06,030 --> 00:14:09,730
+يبدأ انتماؤه في أكثر من المجموعة. في أنا الواحد، لو
+
+170
+00:14:09,730 --> 00:14:15,110
+crisp، لو crisp set، لأ، لا يمكن أي نقطة على هذا الـ
+
+171
+00
+
+223
+00:18:18,540 --> 00:18:25,340
+بيكون الـ variable value هو set يعني x ينتمي إلى a
+
+224
+00:18:25,340 --> 00:18:31,440
+و y ينتمي إلى b فالـ
+
+225
+00:18:31,440 --> 00:18:37,100
+هذا الـ style يتميز بين ما هو الـ crisp و ما هو الـ
+
+226
+00:18:37,100 --> 00:18:42,260
+fuzzy  أعني هذا if speed is greater than 100 then
+
+227
+00:18:42,260 --> 00:18:45,960
+stopping distance is long هنا هذه عبارة عن
+
+228
+00:18:45,960 --> 00:18:51,410
+fuzzy variable value مظبوط هذا الـ variable stopping
+
+229
+00:18:51,410 --> 00:18:56,010
+distance is long  فالـ variable ينتبه إلى fuzzy set
+
+230
+00:18:56,010 --> 00:18:59,550
+بينما هنا speed is greater than one hundred هذا
+
+231
+00:18:59,550 --> 00:19:03,370
+crisp هو يا إما أكبر من مائة يا إما مش أكبر من
+
+232
+00:19:03,370 --> 00:19:08,810
+مائة، صح؟ okay الـ variable speed can have any
+
+233
+00:19:08,810 --> 00:19:11,450
+numerical value between zero و مائتين وعشرين سرعة
+
+234
+00:19:11,450 --> 00:19:14,150
+السيارة ممكن تطلع من صفر إلى مائتين وعشرين
+
+235
+00:19:14,150 --> 00:19:18,620
+but the linguistic variable stopping distance can
+
+236
+00:19:18,620 --> 00:19:22,000
+take either value long أو short long أو short
+
+237
+00:19:22,000 --> 00:19:31,180
+فتقول هذه short صح، okay long و short برضه،  هذا غريب
+
+238
+00:19:31,180 --> 00:19:35,240
+هدول هدول sets long و short هدول عبارة عن sets
+
+239
+00:19:35,240 --> 00:19:42,300
+هذه long و هذه short هذه set  قدام أو يعني حتى حتى
+
+240
+00:19:42,300 --> 00:19:45,860
+لأن إحنا حكينا أن هذه sets و لها درجة انتماء
+
+241
+00:19:45,860 --> 00:19:47,460
+الـ variables بتاخد درجة انتماء في هذه
+
+242
+00:20:00,880 --> 00:20:05,560
+الآن درجة الـ intimacy على أي أساس بتحدد؟ بتحدث على
+
+243
+00:20:05,560 --> 00:20:11,360
+أساس fuzzy membership functions fuzzy membership
+
+244
+00:20:11,360 --> 00:20:12,120
+functions
+
+245
+00:20:18,560 --> 00:20:26,120
+الـ two sets tall و heavy هذه الآن مجموعة الطول
+
+246
+00:20:26,120 --> 00:20:31,300
+وهذه مجموعة الوزن طول
+
+247
+00:20:31,300 --> 00:20:38,820
+الشخص، ناخد الأشخاص اللي بيبقى طولهم من 160 إلى 200 هذا
+
+248
+00:20:38,820 --> 00:20:42,400
+الـ curve هو اللي بيعطيني هذا الـ curve هو اللي
+
+249
+00:20:42,400 --> 00:20:45,420
+بمثل الـ function هذه الـ function هي اللي بتعطيني
+
+250
+00:20:45,420 --> 00:20:52,800
+الـ membership  فأنا عندي شخص طوله 180 سم بالظبط
+
+251
+00:20:52,800 --> 00:21:02,180
+إيش درجة انتمائه لمجموعة الطول؟ حوالي
+
+252
+00:21:02,180 --> 00:21:05,820
+واحد
+
+253
+00:21:05,820 --> 00:21:15,800
+وزنه 80، أنا شوية أكتر من 80 يعني
+
+254
+00:21:15,800 --> 00:21:22,210
+بيقع في جماعة الـ... إيش؟ في جماعة الـ heavy  أما مش
+
+255
+00:21:22,210 --> 00:21:26,210
+يقول fat، كلمة يعني negative، آه فجأة الـ heavy
+
+256
+00:21:26,210 --> 00:21:33,970
+okay فجماعة الـ heavy بيجي حوالي خمسين، شوية خمسين
+
+257
+00:21:33,970 --> 00:21:39,130
+في المئة، okay فببساطة شديدة، ملخص الكلام أنه درجة
+
+258
+00:21:39,130 --> 00:21:43,510
+الانتماء بيعبر عنها بـ membership function تمام
+
+259
+00:21:43,510 --> 00:21:46,910
+فالـ fuzzy membership function اللي شفناه إحنا هنا قبل
+
+260
+00:21:46,910 --> 00:21:50,690
+شوية لما
+
+261
+00:21:50,690 --> 00:21:57,630
+رسمناه و ميّزنا ما بين الـ... الـ crisp sets و ما بين
+
+262
+00:21:57,630 --> 00:22:01,670
+الـ fuzzy sets مش هتقول fuzzy sets ثلاثة، هتقول
+
+263
+00:22:01,670 --> 00:22:06,550
+crisp، هدول برضه منحنى functions بناءً على الـ
+
+264
+00:22:06,550 --> 00:22:12,010
+function هذه، هتساعد زي هيك مرة واحدة بشكل خطي
+
+265
+00:22:12,010 --> 00:22:16,780
+وبعدين تنزل مرة واحدة برضه، عشان كان خطر، صح؟ هذه برضه
+
+266
+00:22:16,780 --> 00:22:19,380
+عبارة عن function، الـ function بتحدد درجة
+
+267
+00:22:19,380 --> 00:22:23,720
+الانتماء، مثلاً هذا الـ value هنا، يعني لو عندي أنا
+
+268
+00:22:23,720 --> 00:22:30,860
+شخص طوله 184 سم
+
+269
+00:22:30,860 --> 00:22:36,540
+فهو بينتمي إلى الـ average، هذه نقطة تقاطع
+
+270
+00:22:36,540 --> 00:22:41,320
+مع مين؟ تقاطع مع الـ function هذا، المتغير عبارة عن
+
+271
+00:22:41,320 --> 00:22:45,620
+function، الـ function بتاع الـ Average، و أيضًا
+
+272
+00:22:45,620 --> 00:22:50,920
+يتقاطع مع الـ function بتاع الـ tall، ماشي، شو معنى
+
+273
+00:22:50,920 --> 00:22:54,860
+هذا الكلام؟ معنى هذا الكلام أن الشخص اللي طوله 184
+
+274
+00:22:54,860 --> 00:23:02,740
+هو member في الـ Average وهو أيضًا member في الـ
+
+275
+00:23:02,740 --> 00:23:08,820
+tall، ليش؟ لأ، في الـ tall، صح؟ في الـ average
+
+276
+00:23:08,820 --> 00:23:18,760
+بنسبة كذا؟ عالية، 10%، و بالنسبة للهندسة 40%، صح؟
+
+277
+00:23:18,760 --> 00:23:23,240
+هذا الكلام؟ أنا رجعت لها الـ slide هذا عشان إيش
+
+278
+00:23:23,240 --> 00:23:28,540
+نوضح نوضح أن الخطوط اللينيار، أشكالها الهندسية هي
+
+279
+00:23:28,540 --> 00:23:34,040
+أيضاً شكل من أشكال الـ membership functions
+
+280
+00:23:34,040 --> 00:23:39,980
+الـ membership functions هدول
+
+281
+00:23:39,980 --> 00:23:47,030
+اللي شفناها قبل، okay واحد كمان، تعطيني الـ
+
+282
+00:23:47,030 --> 00:23:52,010
+membership، الـ degree of membership لو أنا بدأت أفكر
+
+283
+00:23:52,010 --> 00:23:57,650
+فيها من ناحية عملية computational، الـ linear أسرع
+
+284
+00:23:57,650 --> 00:24:02,970
+في الحساب، يعني لو أنا بدي أعمل function وأصممها
+
+285
+00:24:02,970 --> 00:24:07,750
+بحيث أنه أعطيها الـ value هي تعطيني، تعطيني الطول
+
+286
+00:24:07,750 --> 00:24:11,330
+بتاع الشخص وهي تعطيني الـ membership بتاعه، لو الـ
+
+287
+00:24:11,330 --> 00:24:17,140
+function نفسها linear أسرع في الحساب من لو أنها
+
+288
+00:24:17,140 --> 00:24:22,940
+curve، عشان هي كذلك يفضل عشان تسريع الـوجد اللي هو
+
+289
+00:24:22,940 --> 00:24:30,280
+الـ linear functions، هذه برضه مثال يوضح أن لو أنا
+
+290
+00:24:30,280 --> 00:24:34,000
+عندي أكتر من value، هذا بالنسبة للـ height وهذا
+
+291
+00:24:34,000 --> 00:24:39,720
+بالنسبة للـ weight،  يكون المزيج كيف الـ membership تبقى
+
+292
+00:24:39,720 --> 00:24:41,400
+في كل واحد من الـ functions
+
+293
+00:24:55,330 --> 00:24:58,130
+الـ rule طبعاً في الـ fuzzy زي الـ rule في اللي مش
+
+294
+00:24:58,130 --> 00:25:01,470
+fuzzy، ممكن تبقى multiple، إيش الـ condition تبعها؟
+
+295
+00:25:01,470 --> 00:25:04,550
+multiple antecedents يعني multiple يعني أكتر من
+
+296
+00:25:04,550 --> 00:25:11,230
+الشرط بـ and أو بـ or، صح؟ okay الـ consequent إيش
+
+297
+00:25:11,230 --> 00:25:17,180
+ممكن يكون في multiple برضه،  و الـ consequent
+
+298
+00:25:17,180 --> 00:25:22,140
+fuzzy إحنا ما شفناش مثل هذا الكلام في الـ... مش
+
+299
+00:25:22,140 --> 00:25:27,460
+fuzzy، في الـ rules الأخرى اللي قبلها، الآن في الـ
+
+300
+00:25:27,460 --> 00:25:31,860
+fuzzy هل يسمح أن يكون الـ condition، الـ conclusion
+
+301
+00:25:31,860 --> 00:25:36,840
+تبع الـ rule يكون فيها multiple conclusions؟ بالظبط
+
+302
+00:25:36,840 --> 00:25:42,960
+بالظبط، أنه الـ value الواحد، الـ input value الواحد
+
+303
+00:25:42,960 --> 00:25:46,830
+ممكن يكون له انتماء في أكتر من، في ما أكتر من
+
+304
+00:25:46,830 --> 00:25:50,990
+fuzzy sets، وبالتالي ممكن أن تكون rule بتقول لي إذا كان قيمته
+
+305
+00:25:50,990 --> 00:25:58,230
+كذا، قيمة المتغير الفلاني كذا فهو ينتمي إلى هذا
+
+306
+00:25:58,230 --> 00:26:01,350
+المجموعة أو ينتمي إلى هذا المجموعة، إذا الـ
+
+307
+00:26:01,350 --> 00:26:06,090
+temperature is hot فـ hot water is reduced and برضه
+
+308
+00:26:06,090 --> 00:26:09,690
+كمان الـ cold water is increased هذه عبارة عن two
+
+309
+00:26:09,690 --> 00:26:14,490
+actions أو two conclusions أنا بنيتها على تحقق
+
+310
+00:26:14,490 --> 00:26:22,210
+شرط واحد، هذا الآن نهاية الـ slides تبع lecture 4
+
+311
+00:26:22,210 --> 00:26:28,290
+سنكمل الآن من lecture 5 اللي هي بتدخل على طول
+
+312
+00:26:28,290 --> 00:26:34,670
+مباشرة في موضوع الـ inference، موضوع الـ inference
+
+313
+00:26:34,670 --> 00:26:40,810
+بمعنى كيف fuzzy rules بدي أعمل منها أو بدي أعمل
+
+314
+00:26:40,810 --> 00:26:45,980
+expert system على أساس fuzzy rules، الأمر هذا يتم
+
+315
+00:26:45,980 --> 00:26:53,640
+بمعالجة هذه الـ rules، معالجة هذه الـ rules وصولاً إلى
+
+316
+00:26:53,640 --> 00:26:58,020
+الاستنتاج اللي إحنا بندور عليه، في هذا النوعين من
+
+317
+00:26:58,020 --> 00:27:01,960
+الـ inference، في الـ Mamdani inference وفي الـ Sugeno
+
+318
+00:27:01,960 --> 00:27:07,040
+inference، هنطلع على الـ Mamdani بشكل أساسي، وبعدين
+
+319
+00:27:07,040 --> 00:27:12,540
+الـ Sugeno مشابه له بس باختلاف عنه في حاجة بسيطة، إحنا
+
+320
+00:27:12,540 --> 00:27:16,580
+نفهم الـ inference على أساس الـ method  الـ Mamdani و
+
+321
+00:27:16,580 --> 00:27:20,300
+بعدين نطلع على الـ inference على أساس الـ method
+
+322
+00:27:20,300 --> 00:27:29,940
+الـ Mamdani بصفة
+
+323
+00:27:29,940 --> 00:27:35,970
+عامة، fuzzy inference بصفة عامة، والسيستم هذا بياخد
+
+324
+00:27:35,970 --> 00:27:41,570
+input وعلى أساسه بيطلع output، الـ output هذا غالباً
+
+325
+00:27:41,570 --> 00:27:44,770
+إحنا بننظر عليه على أنه decision، قرار اللي بيسوي
+
+326
+00:27:44,770 --> 00:27:50,230
+action معين، فالـ input هذا اللي بيدخل هو عبارة عن
+
+327
+00:27:50,230 --> 00:27:55,010
+معطيات رقمية crisp، إحنا بناءً على الـ fuzzy
+
+328
+00:27:55,010 --> 00:28:00,670
+functions بنحول الـ crisp هذا وبنعطيه membership
+
+329
+00:28:00,670 --> 00:28:07,710
+في الـ fuzzy sets، لأن بناءً على الـ fuzzy sets الآن
+
+330
+00:28:07,710 --> 00:28:12,510
+الـ rules بتتم معالجتها، استنتجنا أنه بما أن المدير
+
+331
+00:28:12,510 --> 00:28:16,280
+الفلاني وقع في المجموعة الفلانية يبقى الـ rule
+
+332
+00:28:16,280 --> 00:28:23,680
+استنتاج تبع حاجة كذا، هذا الأمر يصبح في الـ data set
+
+333
+00:28:23,680 --> 00:28:27,720
+بيعمل fire للـ rule الجديدة و fire للـ rule التانية لما
+
+334
+00:28:27,720 --> 00:28:32,500
+نصل للاستنتاج اللي بدنا إياه، يعني، وفي كل مرة بنحسب الـ
+
+335
+00:28:32,500 --> 00:28:36,740
+what، الـ fuzzy memberships تبع كل استنتاج اللي
+
+336
+00:28:36,740 --> 00:28:37,680
+بنطلعه
+
+337
+00:28:40,090 --> 00:28:42,990
+مناخ العملية، أول شيء يحدث في الـ fuzzification
+
+338
+00:28:42,990 --> 00:28:47,030
+الـ fuzzification هو كما قلنا قبل، crisp value يدخل
+
+339
+00:28:47,030 --> 00:28:51,490
+بناءً على الـ Fuzzy Function، نأخذ درجة انتمائه في
+
+340
+00:28:51,490 --> 00:28:57,110
+الـ Fuzzy Sets، بعد ذلك نشغل Rules، بعد ذلك نعمل
+
+341
+00:28:57,110 --> 00:29:00,530
+Aggregation لـ Rule Outputs لأن هذا سيكون أكتر من
+
+342
+00:29:00,530 --> 00:29:04,520
+Rule fires وكل واحد بتعطينا استنتاج مختلف، ونعمل لهم
+
+343
+00:29:04,520 --> 00:29:08,700
+تجميع عشان نطلع باستنتاج نهائي، هذا الاستنتاج
+
+344
+00:29:08,700 --> 00:29:13,260
+ونعمله de-fuzzification، استنتاج fuzzy ونحوله إلى
+
+345
+00:29:13,260 --> 00:29:16,940
+استنتاج crisp، خذنا ناخذ مثال سريع لهذا الكلام، لأن
+
+346
+00:29:16,940 --> 00:29:21,800
+لو أنا في عندي system
+
+347
+00:29:25,360 --> 00:29:28,040
+هذا الكلام اللي بدأنا فيه المحاضرة الفاترة، إذا
+
+348
+00:29:28,040 --> 00:29:32,800
+بتذكروا لما أنا أول ما دخلت، دخلت في الـ rule في الـ
+
+349
+00:29:32,800 --> 00:29:39,240
+fuzzy rules، في عندي أنا rule رقم واحد، rules
+
+350
+00:29:39,240 --> 00:29:44,500
+مكتوبين بالاختصار، وهنا مكتوبين بعبارة أوضح، if x is
+
+351
+00:29:44,500 --> 00:29:50,880
+a3 if y is b1 if z is c1 لأن a3 و b1 و c1 هدول
+
+352
+00:29:50,880 --> 00:29:55,470
+عبارة عن مجموعات fuzzy sets،  a3 ترمز أنه
+
+353
+00:29:55,470 --> 00:29:59,370
+adequate و x نفسه عبارة عن project funding يعني لو
+
+354
+00:29:59,370 --> 00:30:02,470
+أنا عندي المثال هذا كله على أساس أن أنا فيه عندي
+
+355
+00:30:02,470 --> 00:30:07,110
+مشاريع والمشاريع هذه بناءً على الميزانية تبعها
+
+356
+00:30:07,110 --> 00:30:13,670
+وعدد الـ staff اللي فيها ومتغيرات أخرى بأقدر ما إذا
+
+357
+00:30:13,670 --> 00:30:17,930
+كان المشروع هذا فيه مخاطرة عالية ولا مخاطرة تبعته
+
+358
+00:30:17,930 --> 00:30:21,350
+منخفضة ولا وسط، الـ risk هذا هو الـ output value
+
+359
+00:30:21,350 --> 00:30:26,100
+اللي أنا أدور عليه، okay فالعملية هذه أن أنا لازم
+
+360
+00:30:26,100 --> 00:30:29,940
+يكون في عندي اللي هو الـ fuzzy functions، الـ fuzzy
+
+361
+00:30:29,940 --> 00:30:34,060
+functions اللي على أساسها قيمة المتغير بدي
+
+362
+00:30:34,060 --> 00:30:39,320
+أطلع إيش درجة انتمائه إلى الـ fuzzy sets، فإذا كان
+
+363
+00:30:39,320 --> 00:30:44,020
+أنا x هذه هي عبارة عن الـ project funding يعني قديش
+
+364
+00:30:44,020 --> 00:30:48,040
+ميزانية المشروع، إذا والله الميزانية كانت مائة
+
+365
+00:30:48,040 --> 00:30:51,620
+مليون ولا عشرة مليون ولا كذا، هقول عشرة مليون و
+
+366
+00:30:51,620 --> 00:30:56,090
+لا مائة مليون، أدقوت ولا مش أدقوت بدي أعرف بناءً على
+
+367
+00:30:56,090 --> 00:30:59,870
+مين؟ على fuzzy functions، فهنا هدول، أقول عن fuzzy
+
+368
+00:30:59,870 --> 00:31:07,150
+functions هذه، fuzzy function لـ x وهذه fuzzy
+
+369
+00:31:07,150 --> 00:31:11,110
+function لـ y، الـ y اللي هو إيش قلنا هنا؟ وراء الـ y
+
+370
+00:31:11,110 --> 00:31:15,490
+اللي هو project staffing، x اللي هي إيش؟ project
+
+371
+00:31:15,490 --> 00:31:18,470
+funding
+
+372
+00:31:20,260 --> 00:31:25,820
+و y هو project staffing يعني إيش staffing؟ staffing
+
+373
+00:31:25,820 --> 00:31:29,020
+يعني staff، staff اللي هم العاملين، staffing يعني
+
+374
+00:31:29,020 --> 00:31:32,960
+منسوب بيه حجم الموظفين اللي في المشروع الشغالين
+
+375
+00:31:32,960 --> 00:31:41,440
+المشروع، الـ z هنا اللي هو risk هقول z ولا هقول z
+
+376
+00:31:41,440 --> 00:31:45,540
+إنتوا متعودين، علشان z one ولا z two
+
+377
+00:32:05,830 --> 00:32:14,390
+فهو ينتمي إلى مجموعة a2 بنسبة 20% وينتمي إلى
+
+378
+00:32:14,390 --> 00:32:16,850
+مجموعة a1 بنسبة
+
+379
+00:32:21,520 --> 00:32:34,720
+خلّيني أسمّيهم لهم، الـ Funding A1 يعني
+
+380
+00:32:34,720 --> 00:32:39,180
+المتغير x هيكون تابع لواحد من هدول الثلاثة، الـ A1
+
+381
+00:32:39,180 --> 00:32:47,900
+اللي هي أن يكون low و A2 يكون adequate
+
+382
+00:32:58,910 --> 00:33:11,270
+sorry بس نشوف الـ...
+
+383
+00:33:11,270 --> 00:33:15,410
+okay inadequate
+
+384
+00:33:15,410 --> 00:33:19,590
+و
+
+385
+00:33:19,590 --> 00:33:24,730
+marginal و
+
+386
+00:33:24,730 --> 00:33:24,950
+A3
+
+387
+00:33:32,660 --> 00:33:38,940
+بالنسبة لـ y لأ
+
+388
+00:33:38,940 --> 00:33:46,160
+y لها مجموعتين بس اللي هو small و large، هيكون small
+
+389
+00:33:46,160 --> 00:33:51,300
+و large، الـ high هذا الـ risk، الـ risk اللي لها low و
+
+390
+00:33:51,300 --> 00:33:57,560
+medium و high، فعندك الـ y هتكون لها مجموعتين، b1
+
+391
+00:33:57,560 --> 00:34:07,240
+و b2، b1 بمعنى إيش؟ small وهي
+
+392
+00:34:07,240 --> 00:34:12,540
+بأعداد، مش هيك، بتيجي بمعنى أنها crisp مش هيك، إذا
+
+393
+00:34:12,540 --> 00:34:16,180
+small و large هتيجي بمعنى ذاتي أنها crisp، إيش
+
+394
+00:34:16,180 --> 00:34:23,460
+لازم crisp؟  تيجي
+
+395
+00:34:23,460 --> 00:34:28,380
+ده crisp، if crisp، إذا كان الخط الفاصل ما بين
+
+396
+00:34:28,380 --> 00:34:34,950
+small و large خط قاطع، مافي فيه ضبابية، هنا أنت إيش
+
+397
+00:34:34,950 --> 00:34:39,530
+شايف؟ في ضبابية ولا قاطع؟ مافي ضبابية، تمام، فهو
+
+398
+00:34:39,530 --> 00:34:44,370
+كامل small و large، هذا يعني أنه مجموعتين crisp
+
+399
+00:34:44,370 --> 00:34:50,090
+إذا الحدود ما بينهم ضبابية، وكله fuzzy، إذا الحدود
+
+400
+00:34:50,090 --> 00:34:54,650
+قاطعة تكون crisp
+
+445
+00:38:11,140 --> 00:38:19,140
+A .. أسف، X بتنتمي إلى A1، صح؟ وبنسبة كده؟ و X أيضا
+
+446
+00:38:19,140 --> 00:38:24,800
+تنتمي إلى A2 بنسبة 0.2. هذا من ناحية الـ X، من ناحية
+
+447
+00:38:24,800 --> 00:38:30,010
+الـ Y، طبعا هنا X واحد و Y واحد عشان اختصر، الـ Y تنتمي
+
+448
+00:38:30,010 --> 00:38:39,150
+إلى مين؟ إلى V1 بنسبة 0.1، وايضا تنتمي إلى V2
+
+449
+00:38:39,150 --> 00:38:45,590
+بنسبة 0.7، ماشي؟ الآن، كيف أنا بدي الـ rules هذه؟
+
+450
+00:38:45,590 --> 00:38:49,950
+أطلع على مين منهم تنطبق؟ لأن هذه أمور لا تنطبق
+
+451
+00:38:49,950 --> 00:38:54,710
+تماما، صح؟ لأن مافي عندي أيش؟ X تساوي ايه؟  تلو تساوي
+
+452
+00:38:57,030 --> 00:39:02,630
+أندي هادي ممكن، صح؟ لأنه أنا من ناحية، في عندي الـ Y
+
+453
+00:39:02,630 --> 00:39:10,630
+تنتمي إلى A2، والـ X تنتمي إلى A2، أنا بقدر fire هذا
+
+454
+00:39:10,630 --> 00:39:16,930
+rule، بناء على هذا rule، based on rule 2، أصبح Z
+
+455
+00:39:16,930 --> 00:39:25,510
+تنتمي إلى C2، اللي هي normal، احنا اسمه يكون million
+
+456
+00:39:25,510 --> 00:39:26,310
+normal
+
+457
+00:39:29,400 --> 00:39:37,860
+طيب، رقم ثلاثة، هل تنطبق؟ X is A، ولا هدف؟ أي نعم، انتهى
+
+458
+00:39:37,860 --> 00:39:42,740
+X تنتمي إلى A واحد، تعطيني أيش؟ استنتاج أن Z تنتمي
+
+459
+00:39:42,740 --> 00:39:47,820
+إلى C ثلاثة. اللاحظ، اللاحظ أن أنا أتقابل، أن أنا على
+
+460
+00:39:47,820 --> 00:39:54,740
+رولز هنا، أقول ثلاثة رولز، ثلاثة، باستنتج أنه الآن لحظة
+
+461
+00:39:54,740 --> 00:39:58,340
+أنا استنتجت أن Z تنتمي إلى هذا، و تنتمي إلى هذا
+
+462
+00:39:58,340 --> 00:40:04,080
+وهذا برهان من الـ fuzzyness، أن المتغير واحد ينتمي
+
+463
+00:40:04,080 --> 00:40:08,560
+إلى مجموعتين، فئتين، واحد، ولكن بجدّيش؟ بجدّيش درجة
+
+464
+00:40:08,560 --> 00:40:17,440
+الانتماء؟ كيف؟
+
+465
+00:40:17,440 --> 00:40:21,160
+أحسن درجة الانتماء، أنا عرفت أن Z بناء على الـ rules
+
+466
+00:40:21,160 --> 00:40:27,460
+تنتمي إلى C2 و C3، لكن لم أجد درجة الانتماء. لاحظ أن
+
+467
+00:40:27,460 --> 00:40:29,940
+الـ system تبعنا صغير جدا، لأن الـ three rules اللي
+
+468
+00:40:29,940 --> 00:40:33,320
+لدينا، ولأن احنا عمليا وصلنا للاستنتاج أن الـ risk
+
+469
+00:40:33,320 --> 00:40:38,580
+تبع الـ Z، بس الاستنتاج هذا فظّي، ضبابي، بيقول لي أن الـ
+
+470
+00:40:38,580 --> 00:40:44,800
+Z normal، وفي نفس الوقت بيقول لي أنها high. أنا الآن
+
+471
+00:40:44,800 --> 00:40:48,660
+بدي أفكها هذه الضبابية، وأحولها لـ De-fuzzification
+
+472
+00:40:48,660 --> 00:40:53,860
+بس عشان أفكها، بدي أعرف النسب، اللي هو degree of
+
+473
+00:40:53,860 --> 00:40:57,380
+membership تبع Z في كل واحد من هدولة الـ two sets
+
+474
+00:40:57,380 --> 00:41:05,520
+C2 و C3. بسيطة الحكاية، مش معقدة. تذكروا اللي هو لما
+
+475
+00:41:05,520 --> 00:41:09,660
+يكون في عندي multiple antecedents، وبينهم and، في
+
+476
+00:41:09,660 --> 00:41:13,020
+certainty factor، كنا بناخد الـ certainty factor الـ
+
+477
+00:41:13,020 --> 00:41:18,880
+أيش؟ الأقل، ولما يكون or، ناخد الأكثر، وهنا نفس الشيء
+
+478
+00:41:18,880 --> 00:41:24,620
+أنا الآن، Z2 اجت من Z، انتمائها إلى Z2 اجت بناء على
+
+479
+00:41:24,620 --> 00:41:29,360
+أيه الـ rule؟ الـ rule هادي، صح؟ الـ rule هادي فيها and،
+
+480
+00:41:29,360 --> 00:41:39,520
+أصبت؟ لأن الـ X بتنتمي إلى A2، ها يا طيب، X is
+
+481
+00:41:39,520 --> 00:41:50,680
+A2 بنسبة كده؟ 0.2، صح؟ and Y
+
+482
+00:41:50,680 --> 00:42:03,480
+is D2، 0.7، صح؟ وينها؟ وينها تحت؟ يبقى
+
+483
+00:42:03,480 --> 00:42:11,580
+Z is C2 بنسبة
+
+484
+00:42:11,580 --> 00:42:23,480
+كم؟ ماشي، 0.2. على نفس المنهج، rule ثلاثة، خلاص، rule ثلاثة
+
+485
+00:42:23,480 --> 00:42:26,480
+أصلا مافيش فيها multiple antecedents، كله هو one
+
+486
+00:42:26,480 --> 00:42:33,880
+antecedent، فعلى طول هذه بترتب على هذه تلقائيا، Z is
+
+487
+00:42:33,880 --> 00:42:46,460
+C3، 0.5. برضه الأمور لسه ضبابية، ضبابية، يعني لسه أنا
+
+488
+00:42:46,460 --> 00:42:56,040
+بدي أعرف ايه؟ يعني هي تنتمي إلى C3 لعند كداش؟ النص
+
+489
+00:42:56,040 --> 00:43:05,120
+النص، وفي نفس الوقت لـ C2، C2 عندها ايش؟ واحد من
+
+490
+00:43:05,120 --> 00:43:07,080
+عشرة، هنا، تمام
+
+491
+00:43:08,820 --> 00:43:15,480
+كيف؟ اثنين من عشرة، يعني تقريبا، فهي انتمائها، خلينا
+
+492
+00:43:15,480 --> 00:43:22,860
+هيك وهيك، الرسم هي هذه، أو الصورة هي هذه. تشوف هنا
+
+493
+00:43:22,860 --> 00:43:28,840
+الصورة هذه بتعبر عن ايه؟ اللي هو اثنين من عشرة، اثنين
+
+494
+00:43:28,840 --> 00:43:32,840
+من عشرة، يقطع
+
+495
+00:43:32,840 --> 00:43:33,420
+غلطة هنا
+
+496
+00:43:58,290 --> 00:44:00,770
+مش مشكلة، بقى، عشان ..
+
+497
+00:44:06,490 --> 00:44:14,310
+هو هنا، بناء على رول واحد، إذا X هو A ثلاثة، ودخل
+
+498
+00:44:14,310 --> 00:44:18,590
+A ثلاثة في الموضوع، لماذا؟ هذا ضرر من أن X لا
+
+499
+00:44:18,590 --> 00:44:21,790
+تنتمي إلى A ثلاثة، فهو، ولكنه اعتبر أنه تنتمي
+
+500
+00:44:21,790 --> 00:44:29,110
+بالنسبة للزيرو، ماشي؟ فالكلام هذا لو بدأ أخده على
+
+501
+00:44:29,110 --> 00:44:37,710
+رول واحد، رول رقم واحد، أرجع لورا، طبعا هنا A ثلاثة
+
+502
+00:44:37,710 --> 00:44:46,810
+من اسمه zero، و Y بواحد، من اسمه one، فأخذ الـ one من
+
+503
+00:44:46,810 --> 00:44:51,630
+عشرة، لأكبر، فهذه
+
+504
+00:44:51,630 --> 00:44:56,590
+الكلام اللي أنا عارفه هو الـ one، فهذا الرسم بيمثل
+
+505
+00:44:56,590 --> 00:45:00,590
+لكل اللي أنا كنت أفكر به، طبعا، هذه اللي أنا عارفه
+
+506
+00:45:00,590 --> 00:45:02,190
+هو الـ two، وهذا اللي أنا عارفه هو الـ three
+
+507
+00:45:05,670 --> 00:45:10,370
+C1، منصف الـ 0.4، هنا الـ 0.2 زي ما احنا حسبنا، وهنا
+
+508
+00:45:10,370 --> 00:45:14,570
+الـ 0.4 زي ما احنا حسبنا، إذا هو عبّر عن كل واحد من
+
+509
+00:45:14,570 --> 00:45:22,450
+هدولة بالخط تبع هذه الـ function تبع الـ output اللي
+
+510
+00:45:22,450 --> 00:45:28,190
+هو Z، هي نفس الـ function، إنما هنا أنا عرفت أنه بناء
+
+511
+00:45:28,190 --> 00:45:33,370
+على رموز، الرقم واحد، الـ output بيتقاطع هنا. بالنسبة لأن
+
+512
+00:45:33,370 --> 00:45:35,430
+أنا أقول اثنين، الـ output بتقاطع في هذه المنطقة
+
+513
+00:45:35,430 --> 00:45:39,170
+وبالنسبة لأن أنا أقول ثلاثة، الـ output بتقاطع في
+
+514
+00:45:39,170 --> 00:45:43,370
+هذه المنطقة. الآن، هذول المناطق مظللة، يعني هم
+
+515
+00:45:43,370 --> 00:45:46,410
+ما تطلعش هذا الخط، بتطلع على كل المنطقة اللي تحت
+
+516
+00:45:46,410 --> 00:45:52,870
+الخط، يعني أن الـ output وقع في هذا الحيث، وفي هذا
+
+517
+00:45:52,870 --> 00:45:58,150
+الحيث، وفي هذا الحيث، لأن دمج ثلاثة هدولة في أيش؟
+
+518
+00:46:02,590 --> 00:46:08,890
+دمج الثلاثة استنتاجات، لأن Z ينتمي لـ C1 بنسبة واحد
+
+519
+00:46:08,890 --> 00:46:12,570
+عشرة فمية، و Z ينتمي لـ C2 بنسبة عشرين فمية، و Z ينتمي
+
+520
+00:46:12,570 --> 00:46:20,210
+لـ C3 بنسبة خمسين فمية. دمجهم مع بعض في نفس الـ region
+
+521
+00:46:20,210 --> 00:46:24,470
+في نفس الـ fuzzy set، في fuzzy set واحد. هرجع ثاني
+
+522
+00:46:24,470 --> 00:46:34,540
+مرة أخرى، هذول الثلاثة functions، أخذ هذا مع الـ 20%
+
+523
+00:46:34,540 --> 00:46:41,940
+مع الـ 50%، وطلع عنده أن هو الشكل هذا، هذا
+
+524
+00:46:41,940 --> 00:46:48,820
+الآن، الشكل هو الـ summation تبع الـ output تبع
+
+525
+00:46:48,820 --> 00:46:53,300
+الثلاثة رولز، الكل rule اللي قلته، متباحة عن fuzzy set، هاي
+
+526
+00:46:53,300 --> 00:46:56,240
+الـ fuzzy set هذا، مع هذا الـ fuzzy set، هذا الـ fuzzy
+
+527
+00:46:56,240 --> 00:47:00,520
+set، مجموعة، اللي هو الـ fuzzy set هذا، لأن الـ fuzzy
+
+528
+00:47:00,520 --> 00:47:05,300
+set هذا، بدي أعمله de-fuzzification، أخد منه crisp
+
+529
+00:47:05,300 --> 00:47:12,320
+value، عشان أقول إن Z is risky، أو قيمة الـ risk
+
+530
+00:47:12,320 --> 00:47:20,540
+تبعها، بنسبة كده، بمقدار كده. هي تحدد جدّيش بالظبط الـ
+
+531
+00:47:20,540 --> 00:47:25,640
+risk تبع الـ Z. الطريقة اللي هو الـ defuzzification
+
+532
+00:47:25,640 --> 00:47:30,020
+تحويل من الـ fuzzy set إلى crisp value، أنه احنا هنا
+
+533
+00:47:30,020 --> 00:47:32,360
+الـ defuzzification، الـ last step، اللي هو الـ fuzzy الـ
+
+534
+00:47:32,360 --> 00:47:36,260
+inference process. كل الكلام، الأربع خطوات هدول، يبقى
+
+535
+00:47:36,260 --> 00:47:39,740
+عن الـ inference process: أولا، fuzzification، ثم rule
+
+536
+00:47:39,740 --> 00:47:44,590
+evaluation، ثم aggregation. الخطوة الثالثة كانت
+
+537
+00:47:44,590 --> 00:47:47,770
+aggregation، وبعدها، أربعة، هو الـ defuzzification. أن
+
+538
+00:47:47,770 --> 00:47:52,350
+الـ fuzzy systems help us to evaluate their goals, but the
+
+539
+00:47:52,350 --> 00:47:55,090
+final output of a fuzzy system has to be a crisp
+
+540
+00:47:55,090 --> 00:48:00,230
+number. الـ final output بتعرف
+
+541
+00:48:00,230 --> 00:48:04,270
+درجة المخاطرات بالظبط، جدّيش. has to be a crisp
+
+542
+00:48:04,270 --> 00:48:06,650
+number, and the input of the defuzzification
+
+543
+00:48:06,650 --> 00:48:12,620
+process، وبيطلع منها a single number. الآن، إحدى
+
+544
+00:48:12,620 --> 00:48:17,860
+الطرق لديه fuzzy، فيه يمكن 15 طريقة أو 20 طريقة
+
+545
+00:48:17,860 --> 00:48:22,520
+لتحويل الـ fuzzy outputs إلى crisp value، من الـ fuzzy
+
+546
+00:48:22,520 --> 00:48:26,260
+region. أحدها، أو أسهل processing، اللي هي الـ
+
+547
+00:48:26,260 --> 00:48:30,460
+center of gravity. الـ center of gravity بيختصر شديد
+
+548
+00:48:30,460 --> 00:48:34,560
+أن احنا لو أدي أنا region هذا، الـ region تبعنا، صح؟
+
+549
+00:48:34,560 --> 00:48:36,840
+تبع الـ fuzzy region، أو الـ fuzzy circle تبعنا
+
+550
+00:48:38,530 --> 00:48:43,590
+بنتخيل هذا الكلام كأنه شريحة مجسم، شيء مجسم، معدن
+
+551
+00:48:43,590 --> 00:48:48,650
+أو قشب وكده، وبنتخيل لو .. وين النقطة؟ .. وين النقطة
+
+552
+00:48:48,650 --> 00:48:51,950
+على هذا الـ range؟ هذا الـ range الآن، من zero إلى
+
+553
+00:48:51,950 --> 00:48:57,530
+مين؟ اللي هو درجة المخاطرة، وين النقطة؟ لو أنا حطيت
+
+554
+00:48:57,530 --> 00:49:03,410
+عليها إفتراض، هتعمل balance، والـ shape هذا، عشان
+
+555
+00:49:03,410 --> 00:49:05,950
+اسمه، هي عشان هي اسمها الـ center of gravity، تذكروه
+
+556
+00:49:05,950 --> 00:49:10,730
+في الفيزياء، في الـ astrofthermia، فأسرع طريقة لحساب، أو
+
+557
+00:49:10,730 --> 00:49:14,350
+يعني طريقة discrete، بدل ما نعملها continuous، نعملها
+
+558
+00:49:14,350 --> 00:49:21,750
+discrete، عشان تبسيط، لأن احنا ناخد الـ .. الـ .. الـ
+
+559
+00:49:21,750 --> 00:49:27,310
+.. بالظبط، العشرة، الـ zero، والعشرة، والعشرين، درجة
+
+560
+00:49:27,310 --> 00:49:31,940
+كده؟ point واحد. بنجمع العشرين، والثلاثين، والأربعين، والخمسين
+
+561
+00:49:31,940 --> 00:49:37,200
+والستين، ضرب أيش؟ point اثنين، صح؟ بعدين، اللي هو
+
+562
+00:49:37,200 --> 00:49:41,680
+السبعين، كل الثمانين، والتسعين، والمئة، ضرب اللي هو
+
+563
+00:49:41,680 --> 00:49:46,040
+أيش؟ الـ zero point five، بعدين، هذا الكلام بنجمعه،
+
+564
+00:49:46,040 --> 00:49:49,480
+بنجمعه على عددهم، يعني عندي zero point one، يعني
+
+565
+00:49:49,480 --> 00:49:54,360
+واحدة، اثنين، ثلاثة، صح؟ zero point اثنين، واحدة، اثنين
+
+566
+00:49:54,360 --> 00:50:00,940
+ثلاثة، أربعة، تمام. 0.5 و 0.5 و 0.5 و 0.5 و 0.5 و 0.5
+
+567
+00:50:00,940 --> 00:50:08,300
+و 0.5 و 0.5 و 0.5 و 0.5 و 0.5 و 0.5 و 0.5 و 0.5 و
+
+568
+00:50:08,300 --> 00:50:09,480
+0.5 و 0.5 و 0.5 و 0.5 و 0.5 و 0.5 و 0.5 و 0.5 و 0
+
+569
+00:50:09,480 --> 00:50:09,920
+.5 و 0.5 و 0.5 و 0.5 و 0.5 و 0.5 و 0.5 و 0.5 و 0.5
+
+570
+00:50:09,920 --> 00:50:10,300
+و 0.5 و 0.5 و 0.5 و 0.5 و 0.5 و 0.5 و 0.5 و 0.5 و
+
+571
+00:50:10,300 --> 00:50:11,660
+0.5 و 0.5 و 0.5 و 0.5 و 0.5 و 0.5 و 0.5 و 0.5 و 0
+
+572
+00:50:11,660 --> 00:50:21,240
+.5 و 0.5 و 0.5 و 0.5 و 0.5 و 0.5 و 0.5 و 0.5 و 0.5
+
+573
+00:50:21,240 --> 00:50:22,280
+و
+
+574
+00:50:26,230 --> 00:50:34,790
+درجة المخاطرة بالمئوية، 67.4%. طبعا، الـ system زي هذا
+
+575
+00:50:34,790 --> 00:50:39,170
+صغير، احنا ممكن نعمله if statement، إذا كان كده، فإنه
+
+576
+00:50:39,170 --> 00:50:44,050
+كده، بس هذا الغرض منه كان بس مجرد توضيح آلية الـ
+
+577
+00:50:44,050 --> 00:50:48,850
+inference. طيب، ماشي، احنا الآن عند هذه النقطة، بنكون
+
+578
+00:50:48,850 --> 00:50:54,560
+شرحنا الـ fuzzy inference، بس على أساس اللي هو الممداني
+
+579
+00:50:54,560 --> 00:50:56,660
+method، الممداني method، اللي هي الـ method الأولى
+
+580
+00:50:56,660 --> 00:51:01,800
+السوجينو method. المحاضرة الجاية، بنكملها، وبنشوف أيضا
+
+581
+00:51:01,800 --> 00:51:06,900
+مثال، example، بواسطة expert system، على الطريقتين،
+
+582
+00:51:06,900 --> 00:51:09,400
+على الممداني method، وعلى السوجينو method.
diff --git a/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/4VcCl830pqc_raw.json b/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/4VcCl830pqc_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..25a1e5c4aabf49487f4a6801055c374f212fc5a0
--- /dev/null
+++ b/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/4VcCl830pqc_raw.json
@@ -0,0 +1 @@
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" ..", "probability": 0.85888671875}, {"start": 1439.18, "end": 1439.74, "word": " ال", "probability": 0.97265625}, {"start": 1439.74, "end": 1440.12, "word": " beef", "probability": 0.4931640625}, {"start": 1440.12, "end": 1440.96, "word": " ال", "probability": 0.88916015625}, {"start": 1440.96, "end": 1441.38, "word": " beef", "probability": 0.8974609375}, {"start": 1441.38, "end": 1443.12, "word": " هو", "probability": 0.9853515625}, {"start": 1443.12, "end": 1443.46, "word": " نفس", "probability": 0.99853515625}, {"start": 1443.46, "end": 1443.66, "word": " ال", "probability": 0.5927734375}, {"start": 1443.66, "end": 1444.04, "word": " beef", "probability": 0.91650390625}, {"start": 1444.04, "end": 1444.68, "word": " مش", "probability": 0.96240234375}, {"start": 1444.68, "end": 1445.04, "word": " موجود", "probability": 0.9921875}, {"start": 1445.04, "end": 1445.18, "word": " في", "probability": 0.94287109375}, {"start": 1445.18, "end": 1445.4, "word": " كل", "probability": 0.98046875}, {"start": 1445.4, "end": 1445.64, "word": " هذا", "probability": 0.525390625}, {"start": 1445.64, "end": 1445.78, "word": " الا", "probability": 0.509765625}, {"start": 1445.78, "end": 1446.3, "word": " مرتين", "probability": 0.9886067708333334}], "temperature": 1.0}, {"id": 52, "seek": 145898, "start": 1447.0, "end": 1458.98, "text": "فانبالغ لما انا اكل بيف معالج شيز بيف معالج شيز مش هذا item set أكل مرة موجود مرة واحدة فقط صح فانا في اندي", "tokens": [5172, 7649, 3555, 6027, 17082, 5296, 15042, 1975, 8315, 1975, 28820, 4724, 33911, 20449, 6027, 7435, 13412, 1829, 11622, 4724, 33911, 20449, 6027, 7435, 13412, 1829, 11622, 37893, 23758, 3174, 992, 5551, 28820, 3714, 25720, 3714, 29245, 23328, 3714, 25720, 36764, 24401, 3660, 6156, 47432, 20328, 5016, 6156, 7649, 995, 8978, 16472, 16254], "avg_logprob": -0.3515624972405257, "compression_ratio": 1.4959349593495934, "no_speech_prob": 0.0, "words": [{"start": 1447.0, "end": 1447.46, "word": "فانبالغ", "probability": 0.60810546875}, {"start": 1447.46, "end": 1447.64, "word": " لما", "probability": 0.7166748046875}, {"start": 1447.64, "end": 1447.8, "word": " انا", "probability": 0.6484375}, {"start": 1447.8, "end": 1447.96, "word": " اكل", "probability": 0.54541015625}, {"start": 1447.96, "end": 1448.22, "word": " بيف", "probability": 0.672607421875}, {"start": 1448.22, "end": 1448.6, "word": " معالج", "probability": 0.63818359375}, {"start": 1448.6, "end": 1449.02, "word": " شيز", "probability": 0.720458984375}, {"start": 1449.02, "end": 1450.08, "word": " بيف", "probability": 0.5859375}, {"start": 1450.08, "end": 1450.38, "word": " معالج", "probability": 0.9903971354166666}, {"start": 1450.38, "end": 1450.9, "word": " شيز", "probability": 0.94384765625}, {"start": 1450.9, "end": 1451.58, "word": " مش", "probability": 0.68701171875}, {"start": 1451.58, "end": 1451.72, "word": " هذا", "probability": 0.463134765625}, {"start": 1451.72, "end": 1451.96, "word": " item", "probability": 0.89453125}, {"start": 1451.96, "end": 1452.44, "word": " set", "probability": 0.962890625}, {"start": 1452.44, "end": 1455.04, "word": " أكل", "probability": 0.4466552734375}, {"start": 1455.04, "end": 1455.28, "word": " مرة", "probability": 0.955078125}, {"start": 1455.28, "end": 1455.76, "word": " موجود", "probability": 0.95458984375}, {"start": 1455.76, "end": 1456.12, "word": " مرة", "probability": 0.786376953125}, {"start": 1456.12, "end": 1456.5, "word": " واحدة", "probability": 0.9698893229166666}, {"start": 1456.5, "end": 1456.84, "word": " فقط", "probability": 0.990478515625}, {"start": 1456.84, "end": 1457.58, "word": " صح", "probability": 0.7354736328125}, {"start": 1457.58, "end": 1458.42, "word": " فانا", "probability": 0.80908203125}, {"start": 1458.42, "end": 1458.54, "word": " في", "probability": 0.9716796875}, {"start": 1458.54, "end": 1458.98, "word": " اندي", "probability": 0.59063720703125}], "temperature": 1.0}, {"id": 53, "seek": 148921, "start": 1460.89, "end": 1489.21, "text": "بدي قياس لل frequency تبع اي item set لسه قبل ما احكي عن ال rules و ال confidence تبعها بدي احكم او احكم على ال item sets على اساس ال frequency ايش يعني frequency يعني مدى تكرارها frequency يعني في frequency احنا نفهمها على اساس تذبذب صح؟ بس هنا معناه اخر اللي هو جدش تتكرر في ال data set اللي عندنا", "tokens": [3555, 16254, 12174, 25528, 3794, 24976, 7893, 6055, 3555, 3615, 1975, 1829, 3174, 992, 5296, 3794, 3224, 12174, 36150, 19446, 1975, 5016, 4117, 1829, 18871, 2423, 4474, 4032, 2423, 6687, 6055, 3555, 3615, 11296, 4724, 16254, 1975, 5016, 24793, 1975, 2407, 1975, 5016, 24793, 15844, 2423, 3174, 6352, 15844, 24525, 32277, 2423, 7893, 1975, 1829, 8592, 37495, 22653, 7893, 37495, 22653, 3714, 3215, 7578, 6055, 37983, 9640, 11296, 7893, 37495, 22653, 8978, 7893, 1975, 5016, 8315, 8717, 5172, 16095, 11296, 15844, 24525, 32277, 6055, 8848, 3555, 8848, 3555, 20328, 5016, 22807, 4724, 3794, 34105, 20449, 8315, 3224, 1975, 34740, 13672, 1829, 31439, 10874, 3215, 8592, 6055, 2655, 37983, 2288, 8978, 2423, 1412, 992, 13672, 1829, 43242, 8315], "avg_logprob": -0.23172669403128704, "compression_ratio": 1.9, "no_speech_prob": 0.0, "words": [{"start": 1460.89, "end": 1461.49, "word": "بدي", "probability": 0.5062255859375}, {"start": 1461.49, "end": 1462.09, "word": " قياس", "probability": 0.9114583333333334}, {"start": 1462.09, "end": 1462.29, "word": " لل", "probability": 0.473876953125}, {"start": 1462.29, "end": 1463.01, "word": " frequency", "probability": 0.884765625}, {"start": 1463.01, "end": 1463.57, "word": " تبع", "probability": 0.8821614583333334}, {"start": 1463.57, "end": 1464.41, "word": " اي", "probability": 0.59521484375}, {"start": 1464.41, "end": 1464.71, "word": " item", "probability": 0.859375}, {"start": 1464.71, "end": 1464.97, "word": " set", "probability": 0.9150390625}, {"start": 1464.97, "end": 1465.23, "word": " لسه", "probability": 0.9337565104166666}, {"start": 1465.23, "end": 1465.43, "word": " قبل", "probability": 0.966796875}, {"start": 1465.43, "end": 1465.59, "word": " ما", "probability": 0.9580078125}, {"start": 1465.59, "end": 1465.77, "word": " احكي", "probability": 0.8843994140625}, {"start": 1465.77, "end": 1465.91, "word": " عن", "probability": 0.9931640625}, {"start": 1465.91, "end": 1465.99, "word": " ال", "probability": 0.75244140625}, {"start": 1465.99, "end": 1466.31, "word": " rules", "probability": 0.82470703125}, {"start": 1466.31, "end": 1466.93, "word": " و", "probability": 0.74072265625}, {"start": 1466.93, "end": 1467.03, "word": " ال", "probability": 0.93505859375}, {"start": 1467.03, "end": 1467.39, "word": " confidence", "probability": 0.9892578125}, {"start": 1467.39, "end": 1468.17, "word": " تبعها", "probability": 0.85162353515625}, {"start": 1468.17, "end": 1469.07, "word": " بدي", "probability": 0.8271484375}, {"start": 1469.07, "end": 1470.81, "word": " احكم", "probability": 0.9427083333333334}, {"start": 1470.81, "end": 1471.09, "word": " او", "probability": 0.861572265625}, {"start": 1471.09, "end": 1471.47, "word": " احكم", "probability": 0.9345703125}, {"start": 1471.47, "end": 1471.71, "word": " على", "probability": 0.7705078125}, {"start": 1471.71, "end": 1471.87, "word": " ال", "probability": 0.96142578125}, {"start": 1471.87, "end": 1472.15, "word": " item", "probability": 0.93994140625}, {"start": 1472.15, "end": 1472.61, "word": " sets", "probability": 0.89306640625}, {"start": 1472.61, "end": 1473.37, "word": " على", "probability": 0.8837890625}, {"start": 1473.37, "end": 1473.67, "word": " اساس", "probability": 0.792236328125}, {"start": 1473.67, "end": 1473.85, "word": " ال", "probability": 0.8876953125}, {"start": 1473.85, "end": 1474.37, "word": " frequency", "probability": 0.9873046875}, {"start": 1474.37, "end": 1474.57, "word": " ايش", "probability": 0.8033854166666666}, {"start": 1474.57, "end": 1474.69, "word": " يعني", "probability": 0.81884765625}, {"start": 1474.69, "end": 1475.33, "word": " frequency", "probability": 0.7763671875}, {"start": 1475.33, "end": 1476.11, "word": " يعني", "probability": 0.765380859375}, {"start": 1476.11, "end": 1476.35, "word": " مدى", "probability": 0.68505859375}, {"start": 1476.35, "end": 1477.05, "word": " تكرارها", "probability": 0.90771484375}, {"start": 1477.05, "end": 1478.51, "word": " frequency", "probability": 0.91455078125}, {"start": 1478.51, "end": 1478.71, "word": " يعني", "probability": 0.754638671875}, {"start": 1478.71, "end": 1478.87, "word": " في", "probability": 0.284912109375}, {"start": 1478.87, "end": 1479.39, "word": " frequency", "probability": 0.7900390625}, {"start": 1479.39, "end": 1479.69, "word": " احنا", "probability": 0.6815999348958334}, {"start": 1479.69, "end": 1480.79, "word": " نفهمها", "probability": 0.813232421875}, {"start": 1480.79, "end": 1480.93, "word": " على", "probability": 0.861328125}, {"start": 1480.93, "end": 1481.31, "word": " اساس", "probability": 0.7462158203125}, {"start": 1481.31, "end": 1481.99, "word": " تذبذب", "probability": 0.82138671875}, {"start": 1481.99, "end": 1482.69, "word": " صح؟", "probability": 0.778564453125}, {"start": 1482.69, "end": 1482.89, "word": " بس", "probability": 0.947998046875}, {"start": 1482.89, "end": 1483.01, "word": " هنا", "probability": 0.3056640625}, {"start": 1483.01, "end": 1483.29, "word": " معناه", "probability": 0.7713216145833334}, {"start": 1483.29, "end": 1483.57, "word": " اخر", "probability": 0.85107421875}, {"start": 1483.57, "end": 1483.73, "word": " اللي", "probability": 0.86376953125}, {"start": 1483.73, "end": 1483.97, "word": " هو", "probability": 0.97509765625}, {"start": 1483.97, "end": 1484.39, "word": " جدش", "probability": 0.728515625}, {"start": 1484.39, "end": 1485.01, "word": " تتكرر", "probability": 0.957763671875}, {"start": 1485.01, "end": 1485.25, "word": " في", "probability": 0.91650390625}, {"start": 1485.25, "end": 1486.31, "word": " ال", "probability": 0.96826171875}, {"start": 1486.31, "end": 1488.13, "word": " data", "probability": 0.66357421875}, {"start": 1488.13, "end": 1488.79, "word": " set", "probability": 0.96240234375}, {"start": 1488.79, "end": 1488.99, "word": " اللي", "probability": 0.925537109375}, {"start": 1488.99, "end": 1489.21, "word": " عندنا", "probability": 0.6485595703125}], "temperature": 1.0}, {"id": 54, "seek": 151847, "start": 1490.41, "end": 1518.47, "text": "فبنفهم ما هو مفهوم الـ frequency نحتاج لنفهم مفهوم الـ frequent يعني عندما نقول frequent عمبار item set يعني item set بيتكرر كتير ال item set هذا مرة أخرى بقول قد يكون في عنصر واحد أو قد يكون فيه أكتر الان لو أنا عندي data items", "tokens": [5172, 3555, 1863, 5172, 16095, 19446, 31439, 3714, 5172, 3224, 20498, 2423, 39184, 7893, 8717, 33753, 26108, 5296, 1863, 5172, 3224, 2304, 3714, 5172, 3224, 20498, 2423, 39184, 18004, 37495, 22653, 43242, 15042, 8717, 39648, 18004, 6225, 2304, 3555, 9640, 3174, 992, 37495, 22653, 3174, 992, 4724, 36081, 37983, 2288, 9122, 2655, 13546, 2423, 3174, 992, 23758, 3714, 25720, 5551, 34740, 7578, 4724, 39648, 12174, 3215, 7251, 30544, 8978, 18871, 9381, 2288, 36764, 24401, 34051, 12174, 3215, 7251, 30544, 8978, 3224, 5551, 4117, 2655, 2288, 2423, 7649, 45164, 41850, 18871, 16254, 1412, 4754], "avg_logprob": -0.40924201430158413, "compression_ratio": 1.8071065989847717, "no_speech_prob": 0.0, "words": [{"start": 1490.41, "end": 1491.17, "word": "فبنفهم", "probability": 0.64931640625}, {"start": 1491.17, "end": 1491.47, "word": " ما", "probability": 0.1815185546875}, {"start": 1491.47, "end": 1491.47, "word": " هو", "probability": 0.351318359375}, {"start": 1491.47, "end": 1492.09, "word": " مفهوم", "probability": 0.828857421875}, {"start": 1492.09, "end": 1492.27, "word": " الـ", "probability": 0.687744140625}, {"start": 1492.27, "end": 1493.17, "word": " frequency", "probability": 0.6298828125}, {"start": 1493.17, "end": 1497.37, "word": " نحتاج", "probability": 0.71923828125}, {"start": 1497.37, "end": 1498.03, "word": " لنفهم", "probability": 0.463232421875}, {"start": 1498.03, "end": 1498.59, "word": " مفهوم", "probability": 0.721343994140625}, {"start": 1498.59, "end": 1498.77, "word": " الـ", "probability": 0.725830078125}, {"start": 1498.77, "end": 1499.39, "word": " frequent", "probability": 0.84326171875}, {"start": 1499.39, "end": 1502.71, "word": " يعني", "probability": 0.52984619140625}, {"start": 1502.71, "end": 1502.85, "word": " عندما", "probability": 0.28045654296875}, {"start": 1502.85, "end": 1503.07, "word": " نقول", "probability": 0.922607421875}, {"start": 1503.07, "end": 1503.47, "word": " frequent", "probability": 0.9375}, {"start": 1503.47, "end": 1504.11, "word": " عمبار", "probability": 0.514801025390625}, {"start": 1504.11, "end": 1504.67, "word": " item", "probability": 0.36328125}, {"start": 1504.67, "end": 1505.09, "word": " set", "probability": 0.92041015625}, {"start": 1505.09, "end": 1505.53, "word": " يعني", "probability": 0.7958984375}, {"start": 1505.53, "end": 1505.83, "word": " item", "probability": 0.55078125}, {"start": 1505.83, "end": 1506.07, "word": " set", "probability": 0.93212890625}, {"start": 1506.07, "end": 1506.59, "word": " بيتكرر", "probability": 0.81915283203125}, {"start": 1506.59, "end": 1506.99, "word": " كتير", "probability": 0.8260091145833334}, {"start": 1506.99, "end": 1508.27, "word": " ال", "probability": 0.27978515625}, {"start": 1508.27, "end": 1508.61, "word": " item", "probability": 0.88427734375}, {"start": 1508.61, "end": 1508.87, "word": " set", "probability": 0.96484375}, {"start": 1508.87, "end": 1509.01, "word": " هذا", "probability": 0.196533203125}, {"start": 1509.01, "end": 1509.25, "word": " مرة", "probability": 0.975341796875}, {"start": 1509.25, "end": 1509.61, "word": " أخرى", "probability": 0.9495442708333334}, {"start": 1509.61, "end": 1509.89, "word": " بقول", "probability": 0.647216796875}, {"start": 1509.89, "end": 1510.27, "word": " قد", "probability": 0.9609375}, {"start": 1510.27, "end": 1510.53, "word": " يكون", "probability": 0.9814453125}, {"start": 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item set المحتملة و بعدين تيجي تشوف ال frequency تبع كل واحد ال frequency تبع كل واحد بمعنى ان تبدأ تقول من ال a لحاله ال a لحاله مثلا ال bread لحاله ال milk لحاله", "tokens": [6027, 7649, 23758, 2423, 3174, 992, 28242, 36764, 24401, 9154, 8032, 8848, 12610, 7251, 5172, 43042, 16472, 2423, 9284, 6055, 3555, 3615, 31371, 1975, 12610, 19446, 6055, 1829, 7435, 1829, 6055, 5172, 43042, 3714, 46456, 46538, 2423, 3174, 992, 9673, 33753, 42213, 3660, 4032, 39182, 9957, 6055, 1829, 7435, 1829, 6055, 8592, 38688, 2423, 7893, 6055, 3555, 3615, 28242, 36764, 24401, 2423, 7893, 6055, 3555, 3615, 28242, 36764, 24401, 4724, 2304, 3615, 1863, 7578, 16472, 6055, 44510, 10721, 6055, 39648, 9154, 2423, 257, 5296, 5016, 6027, 3224, 2423, 257, 5296, 5016, 6027, 3224, 50113, 15040, 2423, 5961, 5296, 5016, 6027, 3224, 2423, 5392, 5296, 5016, 6027, 3224], "avg_logprob": -0.2942708366447025, "compression_ratio": 2.0202020202020203, "no_speech_prob": 0.0, "words": [{"start": 1676.46, "end": 1676.8, "word": 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او ال 255 الآن اختزلنا الرقم هذا الى best frequent يعني هنا ال 15 هيطلع منهم بس 1,2,3,4,5,6,7 بس frequent بدال .. اقول .. اطلع rules", "tokens": [44510, 8315, 8717, 8592, 28820, 9154, 11296, 4474, 47525, 6027, 19446, 9122, 8315, 8717, 8592, 28820, 4474, 9154, 28242, 2423, 3174, 6352, 13672, 1829, 20449, 7649, 995, 2423, 2119, 1975, 2407, 2423, 3552, 20, 6024, 48506, 1975, 46456, 11622, 1211, 8315, 34892, 4587, 2304, 23758, 2423, 7578, 1151, 18004, 37495, 22653, 34105, 2423, 2119, 39896, 9566, 1211, 3615, 9154, 16095, 4724, 3794, 502, 11, 17, 11, 18, 11, 19, 11, 20, 11, 21, 11, 22, 4724, 3794, 18004, 47525, 6027, 4386, 1975, 39648, 4386, 1975, 9566, 1211, 3615, 4474], "avg_logprob": -0.330902765194575, "compression_ratio": 1.679144385026738, "no_speech_prob": 0.0, "words": [{"start": 1948.15, "end": 1948.49, "word": "بدنا", "probability": 0.4083099365234375}, {"start": 1948.49, "end": 1948.85, "word": " نشكل", "probability": 0.9265950520833334}, {"start": 1948.85, "end": 1949.11, 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"text": "من 255 او من 15 item sets لأ الان متطالع روز من 7 فقط اهوا بكتير ولا لأ فخطوة ال stage الأولى هي تنجز ليها عملية تقليل ال item sets إلى بس ال frequent in the first stage ايش قلنا ال algorithm finds frequent item sets", "tokens": [27842, 3552, 20, 1975, 2407, 9154, 2119, 3174, 6352, 5296, 10721, 2423, 7649, 44650, 9566, 6027, 3615, 12602, 2407, 11622, 9154, 1614, 6156, 47432, 1975, 3224, 14407, 4724, 4117, 2655, 13546, 49429, 5296, 10721, 6156, 9778, 9566, 2407, 3660, 2423, 3233, 16247, 12610, 7578, 39896, 6055, 1863, 7435, 11622, 32239, 11296, 6225, 42213, 10632, 6055, 4587, 20292, 1211, 2423, 3174, 6352, 30731, 4724, 3794, 2423, 18004, 294, 264, 700, 3233, 1975, 1829, 8592, 12174, 1211, 8315, 2423, 9284, 10704, 18004, 3174, 6352], "avg_logprob": -0.42206324798515044, "compression_ratio": 1.527363184079602, "no_speech_prob": 0.0, "words": [{"start": 1975.81, "end": 1976.25, "word": "من", "probability": 0.4462890625}, {"start": 1976.25, "end": 1978.35, "word": " 255", 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"probability": 0.908203125}, {"start": 1998.67, "end": 1998.77, "word": " ايش", "probability": 0.4586995442708333}, {"start": 1998.77, "end": 1999.13, "word": " قلنا", "probability": 0.9109700520833334}, {"start": 1999.13, "end": 2000.21, "word": " ال", "probability": 0.5009765625}, {"start": 2000.21, "end": 2000.83, "word": " algorithm", "probability": 0.953125}, {"start": 2000.83, "end": 2001.31, "word": " finds", "probability": 0.509765625}, {"start": 2001.31, "end": 2001.79, "word": " frequent", "probability": 0.50244140625}, {"start": 2001.79, "end": 2002.07, "word": " item", "probability": 0.8017578125}, {"start": 2002.07, "end": 2002.49, "word": " sets", "probability": 0.89892578125}], "temperature": 1.0}, {"id": 73, "seek": 201947, "start": 2004.83, "end": 2019.47, "text": "it generates the rules لـ high confidence high confidence يعني ان ال confidence تبعتها أعلى من ال minimum confidence فهذا المثال او هذا الجدول لو أضعت عليه", "tokens": [270, 23815, 264, 4474, 5296, 39184, 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الاساس", "probability": 0.6048177083333334}, {"start": 2302.28, "end": 2302.46, "word": " او", "probability": 0.818115234375}, {"start": 2302.46, "end": 2302.6, "word": " ال", "probability": 0.90185546875}, {"start": 2302.6, "end": 2303.0, "word": " seed", "probability": 0.90576171875}, {"start": 2303.0, "end": 2304.7, "word": " لثلاثيات", "probability": 0.7854352678571429}, {"start": 2304.7, "end": 2305.24, "word": " للاطم", "probability": 0.5539957682291666}, {"start": 2305.24, "end": 2305.44, "word": " سات", "probability": 0.6365966796875}, {"start": 2305.44, "end": 2306.1, "word": " الثلاثية", "probability": 0.927490234375}], "temperature": 1.0}, {"id": 85, "seek": 232748, "start": 2306.54, "end": 2327.48, "text": "الان ثلاثي رباعي خمسي لحد ما اكثر يعني هنا نشوف الواحد و عشرين طلعولي السبعة هدول بعد هيك السبعة دول طلعولي أربعة و بعد هيك الأربعة طلعولي لحد هيك بيبطل يطلع معايا item sets okay الان بعد هيك هي التلاثية", "tokens": [6027, 7649, 38637, 1211, 5718, 104, 1829, 12602, 3555, 45761, 1829, 16490, 2304, 3794, 1829, 5296, 24401, 19446, 1975, 4117, 49115, 37495, 22653, 34105, 8717, 8592, 38688, 2423, 14407, 24401, 4032, 6225, 46309, 9957, 23032, 1211, 3615, 12610, 1829, 21136, 3555, 27884, 8032, 3215, 12610, 39182, 39896, 4117, 21136, 3555, 27884, 11778, 12610, 23032, 1211, 3615, 12610, 1829, 5551, 25513, 27884, 4032, 39182, 39896, 4117, 16247, 25513, 27884, 23032, 1211, 3615, 12610, 1829, 5296, 24401, 39896, 4117, 4724, 1829, 3555, 9566, 1211, 7251, 9566, 1211, 3615, 20449, 995, 25528, 3174, 6352, 1392, 2423, 7649, 39182, 39896, 4117, 39896, 16712, 1211, 5718, 104, 10632], "avg_logprob": -0.3563702063491711, "compression_ratio": 1.9086021505376345, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 2306.54, "end": 2307.68, "word": "الان", "probability": 0.39404296875}, {"start": 2307.68, "end": 2308.38, "word": " ثلاثي", "probability": 0.797021484375}, {"start": 2308.38, "end": 2308.86, "word": " رباعي", "probability": 0.7889404296875}, {"start": 2308.86, "end": 2309.24, "word": " خمسي", "probability": 0.7757568359375}, {"start": 2309.24, "end": 2309.56, "word": " لحد", "probability": 0.824951171875}, {"start": 2309.56, "end": 2309.78, "word": " ما", "probability": 0.28271484375}, {"start": 2309.78, "end": 2310.66, "word": " اكثر", "probability": 0.4605305989583333}, {"start": 2310.66, "end": 2310.92, "word": " يعني", "probability": 0.712158203125}, {"start": 2310.92, "end": 2311.08, "word": " هنا", "probability": 0.365234375}, {"start": 2311.08, "end": 2311.3, "word": " نشوف", "probability": 0.7139892578125}, {"start": 2311.3, "end": 2311.56, "word": " الواحد", "probability": 0.7591959635416666}, {"start": 2311.56, "end": 2311.68, "word": " و", "probability": 0.783203125}, {"start": 2311.68, "end": 2312.1, "word": " عشرين", "probability": 0.760009765625}, {"start": 2312.1, "end": 2313.08, "word": " طلعولي", "probability": 0.8033203125}, {"start": 2313.08, "end": 2314.36, "word": " السبعة", "probability": 0.68310546875}, {"start": 2314.36, "end": 2314.68, "word": " هدول", "probability": 0.8053385416666666}, {"start": 2314.68, "end": 2315.66, "word": " بعد", "probability": 0.724609375}, {"start": 2315.66, "end": 2315.86, "word": " هيك", "probability": 0.5030517578125}, {"start": 2315.86, "end": 2316.26, "word": " السبعة", "probability": 0.90087890625}, {"start": 2316.26, "end": 2316.44, "word": " دول", "probability": 0.8330078125}, {"start": 2316.44, "end": 2317.08, "word": " طلعولي", "probability": 0.80830078125}, {"start": 2317.08, "end": 2317.46, "word": " أربعة", "probability": 0.67626953125}, {"start": 2317.46, "end": 2317.6, "word": " و", "probability": 0.40673828125}, {"start": 2317.6, "end": 2317.68, "word": " بعد", "probability": 0.22802734375}, {"start": 2317.68, "end": 2317.76, "word": " هيك", "probability": 0.84765625}, {"start": 2317.76, "end": 2318.04, "word": " الأربعة", "probability": 0.9192708333333334}, {"start": 2318.04, "end": 2318.54, "word": " طلعولي", "probability": 0.90439453125}, {"start": 2318.54, "end": 2318.92, "word": " لحد", "probability": 0.6890869140625}, {"start": 2318.92, "end": 2319.04, "word": " هيك", "probability": 0.927978515625}, {"start": 2319.04, "end": 2319.74, "word": " بيبطل", "probability": 0.90625}, {"start": 2319.74, "end": 2320.34, "word": " يطلع", "probability": 0.982666015625}, {"start": 2320.34, "end": 2320.76, "word": " معايا", "probability": 0.75439453125}, {"start": 2320.76, "end": 2321.24, "word": " item", "probability": 0.89892578125}, {"start": 2321.24, "end": 2321.7, "word": " sets", "probability": 0.75634765625}, {"start": 2321.7, "end": 2322.58, "word": " okay", "probability": 0.1697998046875}, {"start": 2322.58, "end": 2323.64, "word": " الان", "probability": 0.6268310546875}, {"start": 2323.64, "end": 2323.88, "word": " بعد", "probability": 0.9306640625}, {"start": 2323.88, "end": 2325.0, "word": " هيك", "probability": 0.980224609375}, {"start": 2325.0, "end": 2326.8, "word": " هي", "probability": 0.3369140625}, {"start": 2326.8, "end": 2327.48, "word": " التلاثية", "probability": 0.7853515625}], "temperature": 1.0}, {"id": 86, "seek": 234996, "start": 2327.96, "end": 2349.96, "text": "الان هذا فلاني بكرره بكرره زي ما قلت لحدين ما يبطل معايا يطلع معايا more item sales بعد هيك بيجي دور اللي هو ال rules okay بنكمل المحاضرة الجاية بنحكي فيه أخر نقطة اللي هي كيف ت generate ال rules من ال item sales اللي بتطلع معانا في الأخر قضية بسيطة جدا", "tokens": [6027, 7649, 23758, 6156, 1211, 7649, 1829, 4724, 37983, 2288, 3224, 4724, 37983, 2288, 3224, 30767, 1829, 19446, 12174, 1211, 2655, 5296, 24401, 9957, 19446, 7251, 3555, 9566, 1211, 20449, 995, 25528, 7251, 9566, 1211, 3615, 20449, 995, 25528, 544, 3174, 5763, 39182, 39896, 4117, 4724, 1829, 7435, 1829, 11778, 13063, 13672, 1829, 31439, 2423, 4474, 1392, 44945, 24793, 1211, 9673, 5016, 46958, 25720, 25724, 995, 10632, 44945, 5016, 4117, 1829, 8978, 3224, 5551, 34740, 8717, 47432, 3660, 13672, 1829, 39896, 9122, 33911, 6055, 8460, 2423, 4474, 9154, 2423, 3174, 5763, 13672, 1829, 39894, 9566, 1211, 3615, 20449, 7649, 995, 8978, 16247, 34740, 12174, 11242, 10632, 4724, 3794, 1829, 9566, 3660, 10874, 28259], "avg_logprob": -0.19928727338188573, "compression_ratio": 1.794759825327511, "no_speech_prob": 0.0, "words": [{"start": 2327.96, "end": 2328.34, "word": "الان", "probability": 0.76220703125}, {"start": 2328.34, "end": 2328.72, "word": " هذا", "probability": 0.7626953125}, {"start": 2328.72, "end": 2329.38, "word": " فلاني", "probability": 0.577606201171875}, {"start": 2329.38, "end": 2330.04, "word": " بكرره", "probability": 0.903076171875}, {"start": 2330.04, "end": 2330.56, "word": " بكرره", "probability": 0.84405517578125}, {"start": 2330.56, "end": 2330.72, "word": " زي", "probability": 0.666015625}, {"start": 2330.72, "end": 2330.78, "word": " ما", "probability": 0.9658203125}, {"start": 2330.78, "end": 2331.12, "word": " قلت", "probability": 0.8352864583333334}, {"start": 2331.12, "end": 2331.74, "word": " لحدين", "probability": 0.7505696614583334}, {"start": 2331.74, "end": 2331.84, "word": " ما", "probability": 0.84814453125}, {"start": 2331.84, "end": 2332.18, "word": " يبطل", "probability": 0.96142578125}, {"start": 2332.18, "end": 2332.44, "word": " معايا", "probability": 0.8689778645833334}, {"start": 2332.44, "end": 2332.7, "word": " يطلع", "probability": 0.9190673828125}, {"start": 2332.7, "end": 2333.68, "word": " معايا", "probability": 0.9850260416666666}, {"start": 2333.68, "end": 2334.38, "word": " more", "probability": 0.9052734375}, {"start": 2334.38, "end": 2334.74, "word": " item", "probability": 0.82470703125}, {"start": 2334.74, "end": 2335.12, "word": " sales", "probability": 0.6640625}, {"start": 2335.12, "end": 2336.18, "word": " بعد", "probability": 0.82568359375}, {"start": 2336.18, "end": 2336.56, "word": " هيك", "probability": 0.5771484375}, {"start": 2336.56, "end": 2338.6, "word": " بيجي", "probability": 0.90771484375}, {"start": 2338.6, "end": 2338.86, "word": " دور", "probability": 0.99365234375}, {"start": 2338.86, "end": 2339.08, "word": " اللي", "probability": 0.85791015625}, {"start": 2339.08, "end": 2339.28, "word": " هو", "probability": 0.97802734375}, {"start": 2339.28, "end": 2339.46, "word": " ال", "probability": 0.81201171875}, {"start": 2339.46, "end": 2339.84, "word": " rules", "probability": 0.8369140625}, {"start": 2339.84, "end": 2340.7, "word": " okay", "probability": 0.58056640625}, {"start": 2340.7, "end": 2341.62, "word": " بنكمل", "probability": 0.7419840494791666}, {"start": 2341.62, "end": 2342.06, "word": " المحاضرة", "probability": 0.9781494140625}, {"start": 2342.06, "end": 2342.42, "word": " الجاية", "probability": 0.6682942708333334}, {"start": 2342.42, "end": 2342.8, "word": " بنحكي", "probability": 0.905029296875}, {"start": 2342.8, "end": 2343.16, "word": " فيه", "probability": 0.74658203125}, {"start": 2343.16, "end": 2343.6, "word": " أخر", "probability": 0.7403564453125}, {"start": 2343.6, "end": 2343.9, "word": " نقطة", "probability": 0.8505859375}, {"start": 2343.9, "end": 2344.02, "word": " اللي", "probability": 0.8798828125}, {"start": 2344.02, "end": 2344.28, "word": " هي", "probability": 0.9267578125}, {"start": 2344.28, "end": 2345.34, "word": " كيف", "probability": 0.9677734375}, {"start": 2345.34, "end": 2346.04, "word": " ت", "probability": 0.93310546875}, {"start": 2346.04, "end": 2346.4, "word": " generate", "probability": 0.91650390625}, {"start": 2346.4, "end": 2346.6, "word": " ال", "probability": 0.55712890625}, {"start": 2346.6, "end": 2346.84, "word": " rules", "probability": 0.845703125}, {"start": 2346.84, "end": 2347.04, "word": " من", "probability": 0.9892578125}, {"start": 2347.04, "end": 2347.14, "word": " ال", "probability": 0.96240234375}, {"start": 2347.14, "end": 2347.34, "word": " item", "probability": 0.78857421875}, {"start": 2347.34, "end": 2347.6, "word": " sales", "probability": 0.8544921875}, {"start": 2347.6, "end": 2347.74, "word": " اللي", "probability": 0.970947265625}, {"start": 2347.74, "end": 2348.1, "word": " بتطلع", "probability": 0.9322509765625}, {"start": 2348.1, "end": 2348.36, "word": " معانا", "probability": 0.88818359375}, {"start": 2348.36, "end": 2348.48, "word": " في", "probability": 0.884765625}, {"start": 2348.48, "end": 2348.76, "word": " الأخر", "probability": 0.45001220703125}, {"start": 2348.76, "end": 2349.34, "word": " قضية", "probability": 0.9285481770833334}, {"start": 2349.34, "end": 2349.72, "word": " بسيطة", "probability": 0.9947265625}, {"start": 2349.72, "end": 2349.96, "word": " جدا", "probability": 0.987060546875}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2350.78825, "duration_after_vad": 2248.534374999992}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/ALhp1MicV_Y_raw.srt b/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/ALhp1MicV_Y_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..02a5789e191a90050f9988c4baba1d19c930c16b
--- /dev/null
+++ b/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/ALhp1MicV_Y_raw.srt
@@ -0,0 +1,1848 @@
+1
+00:00:20,790 --> 00:00:23,750
+بسم الله الرحمن الرحيم احنا اليوم ان شاء الله بدنا
+
+2
+00:00:23,750 --> 00:00:30,510
+نكمل ال a priori algorithm اللي هي بتستخدم في
+
+3
+00:00:30,510 --> 00:00:38,110
+استخلاص association rules من a set of transactions
+
+4
+00:00:38,110 --> 00:00:42,730
+ال set of transactions كان اللي هو بنرجع لورا شوية
+
+5
+00:00:42,730 --> 00:00:46,410
+عشان اذكركوا هاي هذا عبارة عن set of transactions
+
+6
+00:00:46,410 --> 00:00:49,530
+ال transaction اللي واحدة بتكون مجموعة من ال items
+
+7
+00:00:50,220 --> 00:00:54,200
+الأن ال algorithm ال a priori algorithm هي عبارة
+
+8
+00:00:54,200 --> 00:00:59,200
+عن الفريقة لاستخلاص rules association rules اللي
+
+9
+00:00:59,200 --> 00:01:04,440
+نقدر نستخدمها في ان احنا نعرف ال item الفلاني ايش
+
+10
+00:01:04,440 --> 00:01:09,860
+عادة لو تم شراءه ايش عادة ممكن يكون ايضا ينشره
+
+11
+00:01:09,860 --> 00:01:10,280
+معاها
+
+12
+00:01:14,620 --> 00:01:19,660
+نرجع تاني لـ Algorithm بس برضه نركز على أن نذكر
+
+13
+00:01:19,660 --> 00:01:23,040
+بمفهوم ال item set ال item set اللي هو أي تشكيلة
+
+14
+00:01:23,040 --> 00:01:27,900
+من ال items مجمع ال items المتاحة أي تشكيلة منها
+
+15
+00:01:27,900 --> 00:01:33,660
+بشكل item set ال item sets هذه ممكن تبقى مفردة أو
+
+16
+00:01:33,660 --> 00:01:41,290
+ممكن تبقى زوجية أو ثلاثية او ايطول حسب كم عدد ال
+
+17
+00:01:41,290 --> 00:01:44,850
+items اللي عندنا هنا item عرب ال items اللي هنا a
+
+18
+00:01:44,850 --> 00:01:49,570
+,b,c,d اربع items بس فبنقدر نشكل اما ثردي او فنائي
+
+19
+00:01:49,570 --> 00:01:54,730
+او ثلاثي او اكتر اشي اللي هو ال item ال items كلها
+
+20
+00:01:54,730 --> 00:01:59,490
+مع بعض ال بعدين المفهوم التاني اللي هو بدنا نذكر
+
+21
+00:01:59,490 --> 00:02:03,110
+ابوه اللي هو ال frequency ال item set a frequency
+
+22
+00:02:03,110 --> 00:02:06,690
+ال frequency تبعت ال item setان هو هذا ال items
+
+23
+00:02:06,690 --> 00:02:12,970
+جداش بتكرره في ال وين مع بعض وين في ال
+
+24
+00:02:12,970 --> 00:02:16,870
+transactions اه ال support بالظبط اللي هو جداش
+
+25
+00:02:16,870 --> 00:02:21,610
+هالولا ال items بظهروا في جداش نسمة ظهورهم في اكم
+
+26
+00:02:21,610 --> 00:02:24,290
+transaction من مجموع ال transactions يعني سبع
+
+27
+00:02:24,290 --> 00:02:29,570
+transactions كمار وظهر هدولا ال ال two items او
+
+28
+00:02:29,570 --> 00:02:32,170
+هذا ال item set او هذا او اي واحد لان ال frequency
+
+29
+00:02:32,170 --> 00:02:38,010
+هذهإذا كان عندي minimum support، معناه ذلك إن أنا
+
+30
+00:02:38,010 --> 00:02:44,250
+معنى بالـ item sets اللي ال frequency تبعتها تساوي
+
+31
+00:02:44,250 --> 00:02:48,150
+أو أكتر من هذا ال minimum، مش معنى بال item sets
+
+32
+00:02:48,150 --> 00:02:52,170
+اللي ال frequency تبعتها أقل من ال minimum
+
+33
+00:02:52,170 --> 00:02:57,770
+support، صح؟ لأنه أنا، زي ما أنتوا شايفين ال item
+
+34
+00:02:57,770 --> 00:03:02,730
+lettuce هي item set lettuce وكنت أكبر كتيرو فانا
+
+35
+00:03:02,730 --> 00:03:05,570
+مش معنى بال .. بال .. بال item sets اللي ال
+
+36
+00:03:05,570 --> 00:03:08,950
+frequency تبعتها ضعيفة بدي ابني rules من item sets
+
+37
+00:03:08,950 --> 00:03:18,230
+اللي ال frequency تبعتها عالية مهو
+
+38
+00:03:18,230 --> 00:03:22,210
+ال frequency .. ال frequency تبعت ال .. ال item
+
+39
+00:03:22,210 --> 00:03:26,070
+set على أساس أنا بتطلع على ال frequency تبعت ال
+
+40
+00:03:26,070 --> 00:03:33,470
+item set بس بدي ..أقل من ال support المطلوب أقل من
+
+41
+00:03:33,470 --> 00:03:37,610
+ال support المطلوب أقل من ال minimum support
+
+42
+00:03:37,610 --> 00:03:41,410
+المفروض يكون أقل من ال frequency المطلوب ماهو ايش
+
+43
+00:03:41,410 --> 00:03:43,390
+ال frequency احنا فيه عندنا minimum support و
+
+44
+00:03:43,390 --> 00:03:47,430
+minimum confidence ايش ال minimum frequency هي ال
+
+45
+00:03:47,430 --> 00:03:49,990
+minimum frequency هي ال minimum support ال
+
+46
+00:03:49,990 --> 00:03:52,710
+frequent support هذه بتختلف ال confidence ال
+
+47
+00:03:52,710 --> 00:03:59,400
+confidence اه لما بيجي ناخد ال item setsبنحسب ال
+
+48
+00:03:59,400 --> 00:04:03,160
+confidence بتاعة ال rule و بنستثنى ال rules اللي
+
+49
+00:04:03,160 --> 00:04:05,800
+ال confidence بتاعة أقل بس ده لسه قدام ال support
+
+50
+00:04:05,800 --> 00:04:08,900
+اللي بنحكيه هو نفس المعنى لل frequency لل
+
+51
+00:04:08,900 --> 00:04:11,700
+frequency بالظبط هو معنى ال frequency يعني كده
+
+52
+00:04:11,700 --> 00:04:15,900
+تكرارها فهو أصلا مفهوم ال support لما احنا حكينا
+
+53
+00:04:15,900 --> 00:04:20,140
+قلنا انه
+
+54
+00:04:20,140 --> 00:04:27,020
+ال rule لما
+
+55
+00:04:27,020 --> 00:04:30,180
+قلنا هى ruleهذا الهدف الواضح ان الـ support تبقى
+
+56
+00:04:30,180 --> 00:04:36,460
+57 ايش يعني؟ يعني هدول الـ two items أجوا مع بعض
+
+57
+00:04:36,460 --> 00:04:43,120
+بتكرار ب frequency في أربعة من سبعة transactions
+
+58
+00:04:43,120 --> 00:04:47,560
+فمن هنا اتبعت ال frequency بال support لما أنا
+
+59
+00:04:47,560 --> 00:04:53,240
+بقول minimum support يعني minimum frequency اتفجنا
+
+60
+00:04:53,240 --> 00:05:00,040
+على ان هنا نستثنىالـ item sets ال frequency تبعتها
+
+61
+00:05:00,040 --> 00:05:06,540
+أقل من ال minimum سبتورد، صح؟ و بنستثنى أي subset،
+
+62
+00:05:06,540 --> 00:05:12,200
+أي item set بيبني عليها، في سؤال تاني؟
+
+63
+00:05:19,070 --> 00:05:21,810
+ال D لحالك؟ اه ال D اللي احنا مستخنينها أساسا من
+
+64
+00:05:21,810 --> 00:05:24,670
+الأول عارف انه مستخنينها ليش مستخنينها لإنه من أقل
+
+65
+00:05:24,670 --> 00:05:27,530
+من او من سبقه اه بس بقدر أطلع في رول برضه ان ال D
+
+66
+00:05:27,530 --> 00:05:31,470
+مش هتيجي إلا لو كان معاها A يعني ك frequency عالي
+
+67
+00:05:31,470 --> 00:05:35,290
+أكتر frequency إيجي معاها ان مثلا على ال A ال D؟
+
+68
+00:05:35,290 --> 00:05:38,130
+اه بس مايكون معاكسي مثلا ال D مستحيل ييجي معاك
+
+69
+00:05:38,130 --> 00:05:42,450
+يعني أو ييجي زي هيك جصدي أنه احنا لما نستخنينها اه
+
+70
+00:05:42,450 --> 00:05:45,580
+تمام؟بالضبط بالأول والآخر ال D هي عبارة عن ال
+
+71
+00:05:45,580 --> 00:05:50,600
+product انا مهتم في ذلك بس ايش انا مهتم في ايش
+
+72
+00:05:50,600 --> 00:05:54,580
+الان انا كده مهتم انه ال D هذه لو بدي انا اجيبها
+
+73
+00:05:54,580 --> 00:05:57,940
+مع product تانية ايش اكتر product انا بدي اضيف
+
+74
+00:05:57,940 --> 00:06:01,800
+معاهم تمام ده ممكن اذا انت معني بيه ايش اكتر
+
+75
+00:06:01,800 --> 00:06:07,880
+product ممكن ييجي معاها تمام بتشوف هذا و هذا ايش
+
+76
+00:06:07,880 --> 00:06:13,010
+ال frequencies بتاعتهمأصلا هذا هو السؤال انه اي
+
+77
+00:06:13,010 --> 00:06:17,770
+item ايش اكتر product ممكن ييجي معاه لأ احنا
+
+78
+00:06:17,770 --> 00:06:21,450
+عاوزين نعرف انه لو انا لو ال customer هشتره دي
+
+79
+00:06:21,450 --> 00:06:26,690
+تمام ايش غالبا هيشتري هيشتري كده و كده طيب بس
+
+80
+00:06:26,690 --> 00:06:33,550
+المهم انه انا ال D هذا ال D هذا اذا هو نسبة شرائه
+
+81
+00:06:33,550 --> 00:06:39,140
+منخفضة جدانسبة شراءه متخفضة للغاية جدا ال business
+
+82
+00:06:39,140 --> 00:06:43,180
+logic انه انا مش معنى بعد هيك اذا هو نفسه متخفض
+
+83
+00:06:43,180 --> 00:06:48,640
+اكتر شراءه يعني مثلا الصاص هذا مش عارف كيف بهمني
+
+84
+00:06:48,640 --> 00:06:54,640
+امره كتير لانه نسبة شراءه هالية صحيح لما تكرر هو ك
+
+85
+00:06:54,640 --> 00:07:01,340
+itemفي أربعة من سبعة سبعة و خمسين هذا مش بسيط انا
+
+86
+00:07:01,340 --> 00:07:03,980
+معنى بالخمسة و عشرين فما فوق مش كان هيك ال minimum
+
+87
+00:07:03,980 --> 00:07:08,580
+support كان هنا في الاول ما بدأنا اول ما بدأنا
+
+88
+00:07:08,580 --> 00:07:12,580
+minimum support تخيلوا items اقل من خمسة و عشرين
+
+89
+00:07:12,580 --> 00:07:18,640
+في الميةمش هتفيدني كتير، ليش؟ لأنه لسه الـ25 هذه،
+
+90
+00:07:18,640 --> 00:07:24,260
+إذا هو أجاري من الـ25، لسه هتضعف ال support مع ال
+
+91
+00:07:24,260 --> 00:07:28,020
+rules اللي بدها تتفرج منهم، و أصل احنا ليش كارين
+
+92
+00:07:28,020 --> 00:07:35,360
+نستثنى؟ ليش تستثنى اللي بتفرع من الـD؟ لأن ال
+
+93
+00:07:35,360 --> 00:07:41,940
+probability، احتمالية ال combination هذههي أقل من
+
+94
+00:07:41,940 --> 00:07:44,260
+ال case تبعتها هي ال probability تبعتها هي ال case
+
+95
+00:07:44,260 --> 00:07:49,300
+تبعتها هي ال probability تبعتها هي ال case تبعتها
+
+96
+00:07:49,300 --> 00:07:50,160
+هي ال case تبعتها هي ال case تبعتها هي ال case
+
+97
+00:07:50,160 --> 00:07:54,860
+تبعتها هي ال case تبعتها هي ال case تبعتها هي ال
+
+98
+00:07:54,860 --> 00:07:55,720
+case تبعتها هي ال case تبعتها هي ال case تبعتها هي
+
+99
+00:07:55,720 --> 00:07:57,840
+ال case تبعتها هي ال case تبعتها هي ال case تبعتها
+
+100
+00:07:57,840 --> 00:07:57,840
+هي ال case تبعتها هي ال case تبعتها هي ال case
+
+101
+00:07:57,840 --> 00:07:57,840
+تبعتها هي ال case تبعتها هي ال case تبعتها هي ال
+
+102
+00:07:57,840 --> 00:08:00,360
+case تبعتها هي ال case تبعتها هي ال case تبعتها هي
+
+103
+00:08:00,360 --> 00:08:07,080
+ال case تبعتها هي ال case تبعتها هي ال case تبعتها
+
+104
+00:08:07,080 --> 00:08:08,820
+هي ال case تبعتها هي ال case تبعتها هي ال case
+
+105
+00:08:08,820 --> 00:08:11,580
+تبعتها هي ال case تبعتها هي العلى هذا المبدأ
+
+106
+00:08:11,580 --> 00:08:15,040
+نستثنى
+
+107
+00:08:15,040 --> 00:08:20,220
+بما أن هذا ال item set ال frequency تبعته أقل من
+
+108
+00:08:20,220 --> 00:08:24,020
+المصبوف يبقى كل ما يبقى أقل يبقى نستثنى من كلهم
+
+109
+00:08:24,020 --> 00:08:30,720
+بعد ذلك
+
+110
+00:08:30,720 --> 00:08:35,160
+رأينا كيف نعمل
+
+111
+00:08:35,160 --> 00:08:39,660
+أولا نبدأ بال single items
+
+112
+00:08:43,700 --> 00:08:48,580
+خلّينا نبدأ بالطلاع على ال steps ال first step ان
+
+113
+00:08:48,580 --> 00:08:54,660
+احنا بنبدأ بال single item بال single item item
+
+114
+00:08:54,660 --> 00:08:57,020
+sets يعني ال item sets اللي بتحتوي على single item
+
+115
+00:08:57,020 --> 00:09:01,680
+تمام نحسب مين ال support تبعه و نستثنى اللي اقل من
+
+116
+00:09:01,680 --> 00:09:06,600
+ال minimum الان هدولة ال single item item sets ال
+
+117
+00:09:06,600 --> 00:09:10,980
+item sets الفردية بنعتبرهم seals عشان نعمل منهم ال
+
+118
+00:09:10,980 --> 00:09:11,540
+two item
+
+119
+00:09:14,750 --> 00:09:18,470
+الزوجية فبنعمل in the second pass ال algorithm
+
+120
+00:09:18,470 --> 00:09:22,690
+uses a sealed set هم عبارة عن single item item set
+
+121
+00:09:22,690 --> 00:09:26,610
+to generate two item two item أيش item sets
+
+122
+00:09:26,610 --> 00:09:30,850
+candidate هنا لأن لسه هم لما نطلعهم ال item sets
+
+123
+00:09:30,850 --> 00:09:34,790
+لسه بدنا نقيم بدنا نحسب ال frequency تبعتهم عشان
+
+124
+00:09:34,790 --> 00:09:40,770
+نشوف مين منهم أكتر و مين منهم أقل من ال support ال
+
+125
+00:09:40,770 --> 00:09:46,410
+minimum فهمأول ما بنعمله جداريش هم Candidates شركة
+
+126
+00:09:46,410 --> 00:09:51,050
+ما بسميهم Candidates بعد ما بنقيمهم نفذ اللي أقل و
+
+127
+00:09:51,050 --> 00:09:57,010
+بنستثنيه و بظهر لنا اللي بناخده لأن each candidate
+
+128
+00:09:57,010 --> 00:10:03,190
+item set is produced by joining two item sets من
+
+129
+00:10:03,190 --> 00:10:06,730
+فردة two single item item sets او ده seed set
+
+130
+00:10:09,590 --> 00:10:13,250
+الان من ال item sets المفردة اعملنا combination
+
+131
+00:10:13,250 --> 00:10:17,330
+لها لان هدولة كلهم عبارة عن واحد وعشرين candidates
+
+132
+00:10:17,330 --> 00:10:21,030
+لما تحسبوا ال frequency تبعهم كيف تحسبوا ال
+
+133
+00:10:21,030 --> 00:10:28,230
+frequency تبعهم نضرر نسبة وجود الاتنين مع بعض في
+
+134
+00:10:28,230 --> 00:10:32,950
+ال transactions اكم ال transactionأجى فيها بيف و
+
+135
+00:10:32,950 --> 00:10:38,430
+بريد مع بعض صح من عدد ال transactions الإجمالي هذه
+
+136
+00:10:38,430 --> 00:10:43,970
+هي ليش ال frequency دمات ال item set ولا لأ؟ اللي
+
+137
+00:10:43,970 --> 00:10:48,030
+منخفض ال frequency دماتي معاني ال minimum support
+
+138
+00:10:48,030 --> 00:10:52,130
+بنستخدمه فبعد ما نسوى هذا العملية طولة معاه بس
+
+139
+00:10:52,130 --> 00:10:58,770
+اللي هو الأربعة الأربعة هدولة okayلأن الأربعة دول
+
+140
+00:10:58,770 --> 00:11:03,870
+لو بيحرن seeds لمن؟ للخطوة اللاحقة اللي هي three
+
+141
+00:11:03,870 --> 00:11:09,010
+item item sets صح؟ كيف ممكن انا اعمل three item
+
+142
+00:11:09,010 --> 00:11:13,110
+item sets من بدي
+
+143
+00:11:13,110 --> 00:11:19,090
+اجي على two مشتركين في أنصر واحد و اعمل اخدي ال
+
+144
+00:11:19,090 --> 00:11:25,690
+union تبقى يعني بدي اجي لبيف milk milk sauce و
+
+145
+00:11:25,690 --> 00:11:32,810
+بصير عندىbeef milk sauce و
+
+146
+00:11:32,810 --> 00:11:36,790
+بعدين beef milk spaghetti طبعا؟ okay لأن انت خد
+
+147
+00:11:36,790 --> 00:11:40,570
+هذا و خد هذا ايش ال union تبقى احنا؟ ال union ليه
+
+148
+00:11:40,570 --> 00:11:46,010
+يحتوي على أصل متكرر صح؟ فبدك ت .. و خد هذا مع هذا
+
+149
+00:11:46,010 --> 00:11:50,470
+برضه خد برضه هذا مع هذا على .. join على spaghetti
+
+150
+00:11:50,470 --> 00:11:56,350
+مظبوط؟ okay و هذا مع هذا join على ال sauce مظبوط؟
+
+151
+00:11:56,710 --> 00:12:01,090
+فبطلع عندك الآن اللي
+
+152
+00:12:01,090 --> 00:12:08,470
+هم واحد اتنين تلاتة هدول التلاتة برضه candidates
+
+153
+00:12:08,470 --> 00:12:15,050
+لما تحسب ال frequency تبعهم و تشوف مين منهم اقل او
+
+154
+00:12:15,050 --> 00:12:20,810
+اعلى من ال minimum support بطلع معاك يعني هذا
+
+155
+00:12:20,810 --> 00:12:29,090
+احسبها او احسبها هنا فبيظل معاهبس اللي هو هذا ال
+
+156
+00:12:29,090 --> 00:12:35,230
+milk sauce spaghetti وال item set الوحيد الأعلى في
+
+157
+00:12:35,230 --> 00:12:37,690
+ال support تبعه ال frequency تبعته من ال minimum
+
+158
+00:12:37,690 --> 00:12:45,930
+support ماشي okay okay الان بعد هيك من هذا ايش انا
+
+159
+00:12:45,930 --> 00:12:50,830
+بقدر اطلع خلاص يعني لو في اندي طلع اتنين ثلاثيات
+
+160
+00:12:50,830 --> 00:12:58,020
+انا ببدأ اأدمجهم عشان أطلع منهم كمان مظبوط لكن
+
+161
+00:12:58,020 --> 00:13:00,460
+مافيش ايه اللي هي ده يبقى حتيجة فالان ال algorithm
+
+162
+00:13:00,460 --> 00:13:04,020
+في ال phase الأول تبعها اللي هو generating ال item
+
+163
+00:13:04,020 --> 00:13:07,800
+set لان لو تتذكروا ال phase الأول أولا generate
+
+164
+00:13:07,800 --> 00:13:16,360
+ايش item sets generate
+
+165
+00:13:16,360 --> 00:13:23,480
+بتحط هنا frequent item sets مظبوط ال algorithm
+
+166
+00:13:23,970 --> 00:13:28,670
+بتطلع لي في الأول بس ال frequency يعني اللي ال
+
+167
+00:13:28,670 --> 00:13:31,650
+frequency بتبعها أكبر من ال .. بعدين الخطوة
+
+168
+00:13:31,650 --> 00:13:38,110
+التانية إيش كانت ال rules ال rules ال association
+
+169
+00:13:38,110 --> 00:13:45,390
+rules فعمليا الان هذا ال item set اللي طلع معانا
+
+170
+00:13:45,390 --> 00:13:52,150
+بدي أبني منه rules بقدر أطلع منه أكتر ruleلأن in
+
+171
+00:13:52,150 --> 00:13:57,770
+general انا لو عندي اي item set why؟ اكمل subset
+
+172
+00:13:57,770 --> 00:14:04,730
+alone هنا تلاتة لو أخدت بيف لحالها لو اشيلت بيف
+
+173
+00:14:04,730 --> 00:14:13,570
+هيطلع معالي milk هاي بيف لحالها subset و milk مع
+
+174
+00:14:13,570 --> 00:14:21,390
+سوس another subset هاي two subsets لو شيلت milk
+
+175
+00:14:22,280 --> 00:14:30,980
+milk لحاله subset و beef مع sauce
+
+176
+00:14:30,980 --> 00:14:34,140
+هاي كمان two subsets هاي السلانة اللي هي اربعة
+
+177
+00:14:34,140 --> 00:14:40,760
+اتنين تلاتة اربعة مظبوط؟ لو شيل صوص لحالة ايش
+
+178
+00:14:40,760 --> 00:14:49,620
+بيضل؟ beef مع milk هي
+
+179
+00:14:49,620 --> 00:14:54,180
+واحد اتنين هي ستة subsetsمظبوط فانا عمليا من
+
+180
+00:14:54,180 --> 00:14:58,160
+subset واحد من item set واحد من item set واحد بقدر
+
+181
+00:14:58,160 --> 00:15:02,380
+اقلع مجموعة من ال subsets لان هذه ال subsets انا
+
+182
+00:15:02,380 --> 00:15:08,080
+معاه اشوف اذا في association ما بينها ولا لأ فانا
+
+183
+00:15:08,080 --> 00:15:13,040
+الان ا leave a frequent item set Y which contains
+
+184
+00:15:13,040 --> 00:15:17,640
+at least two items يعني لو هم بس two items لو Y
+
+185
+00:15:17,640 --> 00:15:26,200
+هذا بيحتوي على بسA و B هذه A لحالها subset و B
+
+186
+00:15:26,200 --> 00:15:36,020
+لحالها subset مظبوط؟ مظبوط انا .. فمن هذول ال two
+
+187
+00:15:36,020 --> 00:15:42,940
+subsets تقوم I بقدر اعمل association rule زي هيك و
+
+188
+00:15:42,940 --> 00:15:47,020
+اعمل rule تانية زي هيك هذول two different rules و
+
+189
+00:15:47,020 --> 00:15:50,900
+هم نفس ال rule two different rules صح؟
+
+190
+00:15:53,500 --> 00:15:58,540
+فعمليا لو عندي item set item set يحتوي بس على
+
+191
+00:15:58,540 --> 00:16:02,800
+اتنين انا ممكن اعمل منه two rules فمن فترة لو
+
+192
+00:16:02,800 --> 00:16:07,920
+تلاتة بقدر اعمل multiple subsets و من ال subsets
+
+193
+00:16:07,920 --> 00:16:14,380
+هذه اعمل multiple rules ال rule هذه الان كل rule
+
+194
+00:16:14,380 --> 00:16:19,520
+ممكن اعملها is a candidate rule كل rule ممكن
+
+195
+00:16:19,520 --> 00:16:25,320
+اعملها is a candidate ruleلحد ما احسب ال
+
+196
+00:16:25,320 --> 00:16:28,920
+confidence تبعها و اشوف اذا ال confidence تبع ال
+
+197
+00:16:28,920 --> 00:16:32,320
+role اكبر من ال minimum من ال minimum confidence
+
+198
+00:16:32,320 --> 00:16:37,040
+بخليها اجالي ال minimum confidence ب .. ارميها ع
+
+199
+00:16:37,040 --> 00:16:40,440
+شكلها صح؟ فالان صارنا الان في ال phase التانية
+
+200
+00:16:40,440 --> 00:16:44,800
+generating the roles مش معناه ذلك بس ان انا اخد
+
+201
+00:16:44,800 --> 00:16:49,240
+subsets و اربطها مع بعض اللي ايضا احسب ال .. زي
+
+202
+00:16:49,240 --> 00:16:53,080
+هنا نفس الشيء هنا كنا generating item setsقلنا to
+
+203
+00:16:53,080 --> 00:16:56,140
+generate اول شي candidate sets فده نحسب اللي هدا و
+
+204
+00:16:56,140 --> 00:17:00,080
+نستثنى اللي اكتر .. اللي اقل منه و هنا نفس الشيء
+
+205
+00:17:00,080 --> 00:17:06,800
+لنا ن generate candidate rules و نستثنى اللي اقل
+
+206
+00:17:06,800 --> 00:17:12,200
+من ال minimum ياش confidence minimum confidence ال
+
+207
+00:17:12,200 --> 00:17:18,140
+confidence تبع ايه هو .. هو ابقى عن ال support تبع
+
+208
+00:17:18,140 --> 00:17:25,890
+ال .. ال .. عندي وايالحالة البسيطة يحتوي على only
+
+209
+00:17:25,890 --> 00:17:34,790
+two items هذا ال
+
+210
+00:17:34,790 --> 00:17:38,030
+item set اللي يحتوي على two items بعمل منه أكام
+
+211
+00:17:38,030 --> 00:17:49,610
+subset اتنين هذا سامع X واحد هذا سامع X واحد وهذا
+
+212
+00:17:49,610 --> 00:17:56,350
+سامع X اتنينهذا subset وهذا subset صح؟ الان لو
+
+213
+00:17:56,350 --> 00:18:03,470
+عملت rule انا ال rule هذه x واحد ال
+
+214
+00:18:03,470 --> 00:18:08,510
+rule هذه عبارة عن ايش ال x اتنين okay الان بديش
+
+215
+00:18:08,510 --> 00:18:15,550
+اكتب x اتنين بدي اكتب y ناقص x واحد بظبط؟ بظبط؟
+
+216
+00:18:15,550 --> 00:18:19,960
+okay بحطهم بجوز زي ما هو زي ما حضرتهم هناهذه واحدة
+
+217
+00:18:19,960 --> 00:18:25,680
+القوانين والثانية القوانين X2 X2 X2 X2 X2 X2 X2 X2
+
+218
+00:18:25,680 --> 00:18:29,600
+X2 X2 X2 X2 X2 X2 X2 X2 X2 X2 X2 X2 X2 X2 X2 X2 X2
+
+219
+00:18:29,600 --> 00:18:29,760
+X2 X2 X2 X2 X2 X2 X2 X2 X2 X2 X2 X2 X2 X2 X2 X2 X2
+
+220
+00:18:29,760 --> 00:18:29,940
+X2 X2 X2 X2 X2 X2 X2 X2 X2 X2 X2 X2 X2 X2 X2 X2 X2
+
+221
+00:18:29,940 --> 00:18:31,800
+X2 X2 X2 X2 X2 X2 X2 X2 X2 X2 X2 X2 X2 X2 X2 X2 X2
+
+222
+00:18:31,800 --> 00:18:32,900
+X2 X2 X2 X2 X2 X2 X2 X2 X2 X2 X2 X2 X2 X2 X2 X2 X2
+
+223
+00:18:32,900 --> 00:18:36,820
+X2 X2 X2 X2 X2 X2 X2 X2
+
+224
+00:18:36,820 --> 00:18:46,900
+X2 X2
+
+225
+00:18:46,900 --> 00:18:47,860
+X
+
+226
+00:18:58,420 --> 00:19:01,440
+هنا لما اقول معايا ال 80% مش هال 80% كانت ال
+
+227
+00:19:01,440 --> 00:19:04,720
+confidence تبعت ايش تبعت ال sauce الى ال spaghetti
+
+228
+00:19:04,720 --> 00:19:17,380
+وين ال Y هنا ال Y هي ال sauce مع ال spaghetti و
+
+229
+00:19:17,380 --> 00:19:23,940
+ال X عندي هي ال sauce تمام
+
+230
+00:19:23,940 --> 00:19:29,560
+و انا اعمل rule بتقولمن X إلى Y نقص X اللي هي يعني
+
+231
+00:19:29,560 --> 00:19:36,480
+من Y نقص X؟ Spaghetti صح؟ شيل الصوص من Y بطالة
+
+232
+00:19:36,480 --> 00:19:40,600
+Spaghetti كمان؟ فالـ S ال confidence تبع هذه كلام
+
+233
+00:19:40,600 --> 00:19:48,160
+ايش كان؟ هو عبارة عن جدّيش نسبة غبور جدّيش ال
+
+234
+00:19:48,160 --> 00:19:54,800
+support تبع هذا كلام كله صح؟ Y
+
+235
+00:19:57,130 --> 00:20:05,010
+على ال support تبع ال X يعني أكم مرة كان ظهر X
+
+236
+00:20:05,010 --> 00:20:13,270
+الصوص؟ خمس مرات Y اللي هم الصوص مع ال spaghetti
+
+237
+00:20:13,270 --> 00:20:17,150
+أكم مرة كان ظهرها؟ أربعة كان عند الصوص ظهرها في
+
+238
+00:20:17,150 --> 00:20:21,530
+خمس transactions أربعة منهم كان معاها الصوص مع ال
+
+239
+00:20:21,530 --> 00:20:29,760
+spaghetti صح؟ فمن هنا أجد 80%اللي هم 4 على 5 وهي
+
+240
+00:20:29,760 --> 00:20:34,420
+نفس حسبتنا
+
+241
+00:20:34,420 --> 00:20:41,480
+هنا صح
+
+242
+00:20:41,480 --> 00:20:45,580
+نرجع تاني وبالتالي انا مابحسب ال confidence دي انا
+
+243
+00:20:45,580 --> 00:20:50,200
+صار عندي candidate rules candidate rules اللي هم
+
+244
+00:20:50,200 --> 00:20:53,480
+هاي واحدة R1
+
+245
+00:20:56,900 --> 00:21:02,240
+YR2 يجب أن تحسب ال confidence R1 يجب أن تحسب ال
+
+246
+00:21:02,240 --> 00:21:14,020
+support الكبير Y على ال support ال condition صح؟
+
+247
+00:21:14,020 --> 00:21:20,520
+إذا كان أكبر من أو يساوي ال minimum يمكن أن أتركها
+
+248
+00:21:24,610 --> 00:21:28,830
+تمام فعندك هنا ال .. ايش اللي احنا كنا بنطلع عليه
+
+249
+00:21:28,830 --> 00:21:34,310
+ال beef مع ال .. في الأول .. ثم شوية .. اوكي
+
+250
+00:21:34,310 --> 00:21:38,390
+لنفترض ان في عندي أنا بغاية تحتوي بس على ال beef و
+
+251
+00:21:38,390 --> 00:21:41,950
+ال milk فلان .. مش عارف تاني
+
+252
+00:21:58,800 --> 00:22:08,820
+الان x واحد هو بيف لحالي تمام و
+
+253
+00:22:08,820 --> 00:22:14,600
+x اتنين هو milk لحالي الان
+
+254
+00:22:14,600 --> 00:22:23,560
+في عندي two rules rule one اللي هي ان x واحد ده
+
+255
+00:22:23,560 --> 00:22:26,320
+هي ترجمتها milk بيف
+
+256
+00:22:30,370 --> 00:22:37,790
+Rule 2 DX2 ترجمتها
+
+257
+00:22:37,790 --> 00:22:42,030
+milk الان
+
+258
+00:22:42,030 --> 00:22:52,310
+ال confidence بيساوي ال support ال confidence تبع
+
+259
+00:22:52,310 --> 00:23:00,660
+rule واحد بيساوي ال support Y علىSupport X1 هو
+
+260
+00:23:00,660 --> 00:23:06,260
+يساوي لو طلعنا نرجع لل transaction حيث نادي بيف و
+
+261
+00:23:06,260 --> 00:23:16,440
+ملك جايين جايين مرتين من السبعة و في ال .. هو ال
+
+262
+00:23:16,440 --> 00:23:19,700
+beef جاي مرتين من السبعة و في المرتين جاي معنا ملك
+
+263
+00:23:19,700 --> 00:23:23,820
+فتسعة
+
+264
+00:23:23,820 --> 00:23:26,720
+و عشرين هي عبارة عن اتنين على السبعةو بيطلع ال
+
+265
+00:23:26,720 --> 00:23:29,740
+support واحد اسم ال confidence واحد confidence
+
+266
+00:23:29,740 --> 00:23:32,060
+معانا ال confidence لحاله بس تلاحظ ان احنا مش
+
+267
+00:23:32,060 --> 00:23:36,200
+معاناين ال confidence لحاله احنا هذه طلعت معانا
+
+268
+00:23:36,200 --> 00:23:38,920
+اصلا لان ال support تبعها كان .. طبعا ال support
+
+269
+00:23:38,920 --> 00:23:43,420
+تبع ال confidence ال sets هادولة كويس لان بس هذا
+
+270
+00:23:43,420 --> 00:23:46,020
+لا يكفي واحد ال support لحاله او ال confidence
+
+271
+00:23:46,020 --> 00:23:50,760
+لحاله يعني لان التانية هتطلع ال confidence تبعها
+
+272
+00:23:53,870 --> 00:23:56,690
+بعد عمره ال 29 هي ال support تبقى طويلة في
+
+273
+00:23:56,690 --> 00:24:03,790
+الحالتين هنا 57% لأن الملك ال support تبقى عالي و
+
+274
+00:24:03,790 --> 00:24:10,270
+بس في مرتين منهم جايم عادي فانخفض ال confidence
+
+275
+00:24:10,270 --> 00:24:15,190
+تبقى أبوه ككل صارت 50% الان هذه على الرغم من ان ال
+
+276
+00:24:15,190 --> 00:24:19,510
+support كويس الا ان ال confidence منخفض فخرقت أحد
+
+277
+00:24:19,510 --> 00:24:23,620
+الشرطين الشرطين اللي لازم يبقىالـ support أكتر من
+
+278
+00:24:23,620 --> 00:24:27,340
+25 و ال confidence أكتر من 75 فهذا ليس حق تطلع حتى
+
+279
+00:24:27,340 --> 00:24:31,700
+استثناء will be discarded عن جهة الهم يعني هو
+
+280
+00:24:31,700 --> 00:24:34,860
+بيأخذ ال minimum من ال confidence لل two rules
+
+281
+00:24:34,860 --> 00:24:38,200
+ايوة بس ال minimum تبع ال support تبع ال support
+
+282
+00:24:38,200 --> 00:24:42,460
+بيجي ليه بيأخذ فيها الأتباع في المرحلة في ال stage
+
+283
+00:24:42,460 --> 00:24:46,960
+one and generating the item sets لما أعمل
+
+284
+00:24:46,960 --> 00:24:52,240
+generating rules بيبين معايا ال confidenceبيعطيك
+
+285
+00:24:52,240 --> 00:24:55,640
+اتفاق ال contents الخاص بهم اتفاق ال contents
+
+286
+00:24:55,640 --> 00:24:58,160
+الخاص بهم اتفاق ال contents الخاص بهم اتفاق ال
+
+287
+00:24:58,160 --> 00:24:59,680
+contents الخاص بهم اتفاق ال contents الخاص بهم
+
+288
+00:24:59,680 --> 00:25:00,800
+اتفاق ال contents الخاص بهم اتفاق ال contents
+
+289
+00:25:00,800 --> 00:25:02,340
+الخاص بهم اتفاق ال contents الخاص بهم اتفاق ال
+
+290
+00:25:02,340 --> 00:25:03,780
+contents الخاص بهم اتفاق ال contents الخاص بهم
+
+291
+00:25:03,780 --> 00:25:07,680
+اتفاق ال contents الخاص بهم اتفاق ال contents
+
+292
+00:25:07,680 --> 00:25:09,160
+الخاص بهم اتفاق ال contents الخاص بهم اتفاق ال
+
+293
+00:25:09,160 --> 00:25:09,160
+contents الخاص بهم اتفاق ال contents الخاص بهم
+
+294
+00:25:09,160 --> 00:25:10,000
+اتفاق ال contents الخاص بهم اتفاق ال contents
+
+295
+00:25:10,000 --> 00:25:17,400
+الخاص بهم اتفاق ال
+
+296
+00:25:17,400 --> 00:25:24,860
+contents الخاص بهم اتفأحنا قلنا بصفة عامة لو عدنا
+
+297
+00:25:24,860 --> 00:25:30,100
+item set ال rules اللي بقدر اعمله هي 2 اقص m نقص
+
+298
+00:25:30,100 --> 00:25:37,700
+واحد صح يعني 2 اقص ثلاثة تمانية نقص واحد سبعة ستة
+
+299
+00:25:37,700 --> 00:25:45,740
+ستة لحظة شوية ممكن يكون واحد منهم confidence تبعه
+
+300
+00:25:45,740 --> 00:25:52,580
+كان متخفض فاستثني صح او لأ لأ لأ لألحظة شوية نرجع
+
+301
+00:25:52,580 --> 00:25:59,280
+تاني لورا ايش احنا قلنا لو انا عندي لو انا عندي M
+
+302
+00:25:59,280 --> 00:26:08,360
+items M items can generate اه لكن ال item sets مش
+
+303
+00:26:08,360 --> 00:26:13,260
+لل إيش ال sub مش لل sub items خلاص مش اشكال الان
+
+304
+00:26:13,260 --> 00:26:17,740
+عندي هذه التلاتة items ايش يعني زي صح ال rule
+
+305
+00:26:17,740 --> 00:26:22,390
+اتنين قصة نقص واحد صح؟لأ هى اتنين واص ام لما كنت
+
+306
+00:26:22,390 --> 00:26:26,670
+دولار عدد يعني ال transactions كلها اللى موجودة
+
+307
+00:26:26,670 --> 00:26:32,070
+عندي متشكلة من كده ام من ال .. عدد ام من ال items
+
+308
+00:26:32,070 --> 00:26:36,630
+بقدرش بقدر اعمل item sets بقدر اعمل item sets هذا
+
+309
+00:26:36,630 --> 00:26:41,290
+الان item set تمام احنا الآن سؤالنا هو انا هندي
+
+310
+00:26:41,290 --> 00:26:44,850
+item set يحتوي على كده item اكا مرول بقدر اعمل
+
+311
+00:26:44,850 --> 00:26:48,810
+منها okayفهي عموما زي ما انا سويه تتولى لما كنا
+
+312
+00:26:48,810 --> 00:26:53,270
+بدأنا بالاصل بدأنا بتلقى items وعملنا منهم ستة اه
+
+313
+00:26:53,270 --> 00:26:57,570
+بتحدث واحدة بتعمل فعملنا
+
+314
+00:26:57,570 --> 00:27:04,790
+ان هو ستة من من تلقى items عملنا ستة subsets ستة
+
+315
+00:27:04,790 --> 00:27:08,410
+subsets يعني الستة subsets هدولة بدأت تاخدهم مع
+
+316
+00:27:08,410 --> 00:27:14,270
+بعض بتعمل منهم rules لإن هدو ال rules ال
+
+317
+00:27:14,270 --> 00:27:16,250
+confidence توحى مية في المية و هدولة
+
+318
+00:27:19,960 --> 00:27:26,700
+discarded نعم فأصبح ايش الخلاصة انه انت in general
+
+319
+00:27:26,700 --> 00:27:32,540
+اذا عندك k item okay هيت اللي كنت بدي احكيها k
+
+320
+00:27:32,540 --> 00:27:38,860
+item is a set يعني زي هذا هذا ال set بيحتوي على k
+
+321
+00:27:38,860 --> 00:27:43,100
+number of items تلاتة فمقدر اعمل اتنين اصر k ناقص
+
+322
+00:27:43,100 --> 00:27:47,890
+اتنين okay اللي هم الستassociation rules لأن مش كل
+
+323
+00:27:47,890 --> 00:27:50,010
+هذه الـ association rules بتضلها هده كلهم
+
+324
+00:27:50,010 --> 00:27:53,870
+candidates حسب ال confidence تبقى كل rule بتبيز
+
+325
+00:27:53,870 --> 00:27:57,690
+كده تضلها ولا لأ okay هندي أربع items can be
+
+326
+00:27:57,690 --> 00:28:00,770
+presented بعض أعمل منهم أربعاش association rules
+
+327
+00:28:00,770 --> 00:28:05,430
+okay الآن ال letters هذي هذي ال letters زي هذيك ال
+
+328
+00:28:05,430 --> 00:28:09,630
+letters بس هذي ال rules okay هذي ال node الواحدة
+
+329
+00:28:09,630 --> 00:28:12,930
+هنا مانعنياشrule هناك ال node الواحد كانت عبارة عن
+
+330
+00:28:12,930 --> 00:28:19,130
+subset subset صح نرجع تاني بس بدأنا احنا بال
+
+331
+00:28:19,130 --> 00:28:26,090
+subset الكبير او من ال mt عندي ال items هذا عبارة
+
+332
+00:28:26,090 --> 00:28:29,490
+عن .. كل واحد منهم عبارة عن subset بس single item
+
+333
+00:28:29,490 --> 00:28:34,990
+هنا subsets two item كلهم subset من ال set الكبير
+
+334
+00:28:36,550 --> 00:28:40,430
+بس عندى هنا الان في ال lattice التالية العنصر
+
+335
+00:28:40,430 --> 00:28:45,150
+الواحدة معناه انه ال rule ده ال rule الان لو انت
+
+336
+00:28:45,150 --> 00:28:51,350
+طلعت بالاساس ال rule هذه بتقول اذا كان موجود A وB
+
+337
+00:28:51,350 --> 00:28:55,130
+وC وD فمابقاش اشي اصلا ينشره اذا هم كل ال items
+
+338
+00:28:55,130 --> 00:28:59,730
+اللى عندى اربعة و هو اشترى الأربعة فمافي اشي
+
+339
+00:28:59,730 --> 00:29:06,380
+استنتجه صح لأ لو انت اخدت واحد من هدولةطبعا هنا
+
+340
+00:29:06,380 --> 00:29:10,920
+انت ماخد ال D شايل ال D و ناجله على ال conclusion
+
+341
+00:29:10,920 --> 00:29:14,020
+لو انت أخدت ال D و ناجلته على ال conclusion هاي
+
+342
+00:29:14,020 --> 00:29:19,440
+رول ايه دي C لو أخدت ال C و ناجلته على ال
+
+343
+00:29:19,440 --> 00:29:23,500
+conclusion بيصير عندك رول تاني أخدت ال B على ال
+
+344
+00:29:23,500 --> 00:29:28,200
+conclusion صح ان انت في كل واحدة من دولة ناجلتها
+
+345
+00:29:28,200 --> 00:29:34,790
+لان من هذه بعد ذلك ايش في احتمالات أمامك انكدى بس
+
+346
+00:29:34,790 --> 00:29:38,450
+الفكرة الموجودة ممكن تنجل ال a معناها أو تنجل ال b
+
+347
+00:29:38,450 --> 00:29:47,810
+أو تنجل ال c هى تلت options إذا نجلت ال c فصلا
+
+348
+00:29:47,810 --> 00:29:55,990
+عندك ال rule هذه بل إحنا الآن بس بنعمل تمثيل
+
+349
+00:29:55,990 --> 00:30:02,750
+لعملية لمجموعة ال rules اللى يمكنتوليدها من الـ
+
+350
+00:30:02,750 --> 00:30:08,110
+subsets تبع هذا ال item set هذا ال item set و ال
+
+351
+00:30:08,110 --> 00:30:16,070
+subsets تبعونه يمكن بناء rules منها وهذا لل rule
+
+352
+00:30:16,070 --> 00:30:21,170
+space يعني كل الاحتمالات هذه أبدا عن rule صح تحتاج
+
+353
+00:30:21,170 --> 00:30:27,010
+على ال item set هذا أو ال subset هذا ال subset هذا
+
+354
+00:30:27,010 --> 00:30:29,890
+في ال condition و ال subset هذا في ال conclusion
+
+355
+00:30:30,550 --> 00:30:36,210
+هذا عبارة عن subset مفرد وانا subset ثلاثي هنا بعد
+
+356
+00:30:36,210 --> 00:30:40,450
+level 2 بيبدأ تطلع ال frequency ثانى شوية في ال
+
+357
+00:30:40,450 --> 00:30:48,370
+level الأول يعني عبارة عن تلاتة item في ال
+
+358
+00:30:48,370 --> 00:30:55,590
+condition single item في ال conclusion هنا ال two
+
+359
+00:30:55,590 --> 00:30:59,290
+item في ال conditionو two item في ال conclusion
+
+360
+00:30:59,290 --> 00:31:04,750
+هنا one item في ال condition و تلاتة في ال
+
+361
+00:31:04,750 --> 00:31:08,330
+consequence اللي هي ال conclusion okay الآن إيش ال
+
+362
+00:31:08,330 --> 00:31:13,770
+.. الآن هنا في كلهم بيحسب ال frequency الأبيض
+
+363
+00:31:13,770 --> 00:31:17,490
+هدولة ال frequency تبعت ال rule ال frequency ..
+
+364
+00:31:17,490 --> 00:31:22,290
+أسف مش frequency confidence تبعة ال rule okay لأن
+
+365
+00:31:22,290 --> 00:31:26,610
+هذا ال rule ال confidence تبعها ال confidence
+
+366
+00:31:26,610 --> 00:31:27,610
+تبعها low
+
+367
+00:31:31,550 --> 00:31:36,130
+أي رول أخرى
+
+368
+00:31:36,130 --> 00:31:44,990
+.. أي رول أخرى ال condition تبعها .. أي
+
+369
+00:31:44,990 --> 00:31:48,950
+رول أخرى ال condition تبعها يحتوي على ال condition
+
+370
+00:31:48,950 --> 00:31:51,690
+تبعها هذه قررتها low
+
+371
+00:31:57,120 --> 00:32:00,920
+ال conclusion تبعها او ال consequent تبعها بيحتوي
+
+372
+00:32:00,920 --> 00:32:07,520
+على بيشتمل على ال consequent تبع rule low
+
+373
+00:32:07,520 --> 00:32:11,260
+confidence فهي low confidence يعني في ال lattice
+
+374
+00:32:11,260 --> 00:32:14,920
+تبعت ال rules احنا كنا في ال lattice تبعت ال item
+
+375
+00:32:14,920 --> 00:32:18,240
+sets كنا ندور احنا على ال support هنا سدنا نعمل
+
+376
+00:32:18,240 --> 00:32:20,200
+pruning على اساس ال confidence على اساس ال
+
+377
+00:32:20,200 --> 00:32:26,790
+confidence على اساس ال confidence بس كيفحسبت أن
+
+378
+00:32:26,790 --> 00:32:31,130
+هذه من خلال المعادلة حسبت ال confidence بتاعي أقل
+
+379
+00:32:31,130 --> 00:32:35,290
+من ال minimum فعلمت أن هذه low confidence وحسيت
+
+380
+00:32:35,290 --> 00:32:39,270
+أثنينها لأن بعد شوية عملت generate ل other rules
+
+381
+00:32:39,270 --> 00:32:43,510
+لجيت أنه الآن بد أحسب ال confidence قبل ما أحسب ال
+
+382
+00:32:43,510 --> 00:32:47,250
+confidence لجيت أن هذا ال rule ال consequent
+
+383
+00:32:47,250 --> 00:32:48,270
+بيحتوي
+
+384
+00:32:53,070 --> 00:32:57,570
+على subset هذا ال subset مطابق لل subset تبع low
+
+385
+00:32:57,570 --> 00:33:01,410
+confidence role يعني في جهة انا على طول بعلمها low
+
+386
+00:33:01,410 --> 00:33:08,070
+confidence بدون ما احسب okay صح لأ خلّي بالك انه
+
+387
+00:33:08,070 --> 00:33:13,930
+التوفير اللي انا بغفره في اني انا محسبش هنا تقريبا
+
+388
+00:33:13,930 --> 00:33:17,910
+بسيط ليش لأن حسبة ال confidence تبع جوجل هي عبارة
+
+389
+00:33:17,910 --> 00:33:26,920
+عن ال support تبعY على ال support تبع ال X أو ال
+
+390
+00:33:26,920 --> 00:33:30,800
+condition غالبا انا بكون حاسب ال support تبع ال
+
+391
+00:33:30,800 --> 00:33:35,300
+condition تبع Y مسبقا و حاسب ال support تبع هذا
+
+392
+00:33:35,300 --> 00:33:41,760
+مسبقا وبالتالي بس عملية قسمة الرقمين على بعض يعني
+
+393
+00:33:41,760 --> 00:33:45,660
+انا اللي وفرته على حالي في ان انا ماحسبش مش كتير
+
+394
+00:33:45,660 --> 00:33:50,940
+زي هناك هناك انا عشان احسبالـ supportable items ان
+
+395
+00:33:50,940 --> 00:33:54,520
+انت بتعمل عملية احصائية اجيب اكم مرة هو موجود في
+
+396
+00:33:54,520 --> 00:33:59,520
+ال transactions و اعدهم و اجسم على اكم مرة موجود
+
+397
+00:33:59,520 --> 00:34:05,080
+مظبوط فهنا انا اللي حاسب ان انا فيها توفير اقل بس
+
+398
+00:34:05,080 --> 00:34:08,340
+عموما كان ال rule القاعدة اللي بدأ اطبقها عشان
+
+399
+00:34:08,340 --> 00:34:16,100
+اعمل استثناء انه هذا الان هذا الان بتفرج منه ا ..
+
+400
+00:34:16,100 --> 00:34:22,430
+ا ..هذا هو رولي ايش احتمال يتولد منها تطبق نفس
+
+401
+00:34:22,430 --> 00:34:28,530
+القالي يشيل هذا و يحط هنا هاي one case صح هاي ال B
+
+402
+00:34:28,530 --> 00:34:31,590
+أجت من ال condition و نحط على ال conclusion او شيل
+
+403
+00:34:31,590 --> 00:34:38,950
+ال A و حطها و هاي ال case التاني صح لأن هذه نفسها
+
+404
+00:34:38,950 --> 00:34:49,120
+برضه أجت من هنا لما شيلنا ال D و حطناها هناصارت بي
+
+405
+00:34:49,120 --> 00:34:54,900
+و a b و a c d الان هذه ال node لما اتولدت من هنا
+
+406
+00:34:54,900 --> 00:35:01,120
+هذه high confidence ليش عملها؟ ماعليش ماهو لما هو
+
+407
+00:35:01,120 --> 00:35:06,180
+بيبص من هذا الاتجاه بيعتبر الشهادة low confidence
+
+408
+00:35:06,180 --> 00:35:09,720
+بس لما بيجي من هذا الاتجاه هو قادر انها low
+
+409
+00:35:09,720 --> 00:35:13,260
+confidence بيجيها بيعتبر احنا low confidence طبعا
+
+410
+00:35:13,260 --> 00:35:18,830
+يبقى انا يبقى انا الانإذا لما تتولق .. لما يبني ان
+
+411
+00:35:18,830 --> 00:35:23,550
+اعمل generation of learn rules بدي أفحص ال
+
+412
+00:35:23,550 --> 00:35:28,950
+consequence تبع ال form أشوف ال consequence تبع ال
+
+413
+00:35:28,950 --> 00:35:35,150
+form تحتوي على subset موجود ك consequence ..
+
+414
+00:35:35,150 --> 00:35:38,730
+كconsequent لو واحدة من ال rules السابقة low
+
+415
+00:35:38,730 --> 00:35:43,860
+confidence يبقى هو .. okayفالمرة أخرى بقول هي هذا
+
+416
+00:35:43,860 --> 00:35:50,160
+متولد من تلاتة parents هذا و هذا و هذا و الان صح
+
+417
+00:35:50,160 --> 00:35:57,880
+هذه النقطة لكن واحدة بس منهم واحدة من النص كانت
+
+418
+00:35:57,880 --> 00:36:02,940
+low confidence فادت انه احنا نستخلص انه low
+
+419
+00:36:02,940 --> 00:36:05,640
+confidence خلي بال لو احنا مابدناش نعمل pruning و
+
+420
+00:36:05,640 --> 00:36:09,660
+نحسب هنحسب و نلاقي low confidence صح انا لو احنا
+
+421
+00:36:09,660 --> 00:36:12,930
+حسبنا على اساس support على supportهل هسبوا اللي
+
+422
+00:36:12,930 --> 00:36:17,450
+جيه؟ فهل عندي واحد طريق تاني، يا إما بحسبها حسابا،
+
+423
+00:36:17,450 --> 00:36:24,790
+يا إما بستنبطها استنباطا من ال consequence تبع أي
+
+424
+00:36:24,790 --> 00:36:27,610
+واحد من ال parents، ما هو اللي هو ممكن يكون أكتر
+
+425
+00:36:27,610 --> 00:36:31,850
+من ال parents. أولا فهذه القليل اللي في الآخر بنتج
+
+426
+00:36:31,850 --> 00:36:37,390
+عنها مجموعة اللي هو إيش؟مجموعة ال association
+
+427
+00:36:37,390 --> 00:36:41,250
+rules اللي اقدر استند اليها طب انا بقدر اغير ال
+
+428
+00:36:41,250 --> 00:36:44,990
+minimum confidence اغير ال minimum support حسب
+
+429
+00:36:44,990 --> 00:36:50,030
+احتياجات ال application بس هنا .. هنا انا خلاص صرت
+
+430
+00:36:50,030 --> 00:36:54,210
+مهمل في اخر .. في رابع level صار انه لو هو ما شراش
+
+431
+00:36:54,210 --> 00:36:58,590
+اشي او هو لسه ما شراش اشي اه انا عند احتمال انه
+
+432
+00:36:58,590 --> 00:37:01,370
+مايشتري اي حاجة احتمال انه مايشتري اشي هو برضه فيه
+
+433
+00:37:01,370 --> 00:37:05,320
+low confidence هنا صار عندك ايوة صح صحاحتمال انه
+
+434
+00:37:05,320 --> 00:37:09,780
+مايشتريش .. هو دخل ال .. هو دخل ال .. هو دخل ال ..
+
+435
+00:37:09,780 --> 00:37:10,980
+هو دخل ال .. هو دخل ال .. هو دخل ال .. هو دخل ال
+
+436
+00:37:10,980 --> 00:37:11,740
+.. هو دخل ال .. هو دخل ال .. هو دخل ال .. هو دخل
+
+437
+00:37:11,740 --> 00:37:12,720
+ال .. هو دخل ال .. هو دخل ال .. هو دخل ال .. هو
+
+438
+00:37:12,720 --> 00:37:13,500
+دخل ال .. هو دخل ال .. هو دخل ال .. هو دخل ال ..
+
+439
+00:37:13,500 --> 00:37:15,500
+هو دخل ال .. هو دخل ال .. هو دخل ال .. هو دخل ال
+
+440
+00:37:15,500 --> 00:37:16,240
+.. هو دخل ال .. هو دخل ال .. هو دخل ال .. هو دخل
+
+441
+00:37:16,240 --> 00:37:17,440
+ال .. هو دخل ال .. هو دخل ال .. هو دخل ال .. هو
+
+442
+00:37:17,440 --> 00:37:25,020
+دخل ال .. هو دخل ال .. هو دخل ال .. هو دخل ال ..
+
+443
+00:37:25,020 --> 00:37:30,260
+هو دخل ال ..
+
+444
+00:37:30,260 --> 00:37:38,420
+هو دخل ال .. هواه صح؟ اه و هي احتمالية تلالي جدا و
+
+445
+00:37:38,420 --> 00:37:41,780
+صح ممكن يجيلك واحد و يطلع زي ما صارت معايا انا مرة
+
+446
+00:37:41,780 --> 00:37:45,000
+خشيت في ال supermarket و طلعت ما الشارع لا حاجة و
+
+447
+00:37:45,000 --> 00:37:49,800
+صاح المحل اللي حجنه مني ضحكني على الشارع تخيل و مش
+
+448
+00:37:49,800 --> 00:37:53,300
+هو صاح المحل اللي حجنيه بعت واحد من العمال و هذا
+
+449
+00:37:53,300 --> 00:37:57,280
+الكلب حصل في عمان يعني انا خلت ال supermarket و
+
+450
+00:37:57,280 --> 00:38:00,850
+طلعتفبعد ما مشيت انك عشرة متر اللي بيقول أجي واحد
+
+451
+00:38:00,850 --> 00:38:04,210
+ورايه و بيقوللي يا استاذ ات صاحب المحل بيقولك ات
+
+452
+00:38:04,210 --> 00:38:09,870
+خشيته، والله حصل معاك، المهم يعني بتحصل بس نادرة،
+
+453
+00:38:09,870 --> 00:38:11,950
+هي إيش يعني low confidence؟ مش معناه تقينها
+
+454
+00:38:11,950 --> 00:38:15,150
+مستحيلة، معناه تقينها أقل من ال .. انه unlikely to
+
+455
+00:38:15,150 --> 00:38:17,990
+happen .. unlikely بالنسبة لمن؟ بالنسبة ل ال
+
+456
+00:38:17,990 --> 00:38:19,550
+confidence factor اللي أنت حطيته
+
+457
+00:38:32,110 --> 00:38:42,110
+هذا هو خلاصة
+
+458
+00:38:42,110 --> 00:38:46,550
+الامر بالنسبة لـ Association Rules وقالية
+
+459
+00:38:46,550 --> 00:38:51,630
+استنباطها من الـ Item Salesماشي هيك من خلاص و
+
+460
+00:38:51,630 --> 00:38:53,630
+المحاضرة اللي جاي ان شاء الله بنبدأ في الموضوع
+
+461
+00:38:53,630 --> 00:38:56,270
+الأخير اللي هو ال principal components of
+
+462
+00:38:56,270 --> 00:38:56,710
+businesses
+
diff --git a/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/HLgYDIGhP90.srt b/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/HLgYDIGhP90.srt
new file mode 100644
index 0000000000000000000000000000000000000000..98709cff08a3c25f1da585d0418b392843d7258b
--- /dev/null
+++ b/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/HLgYDIGhP90.srt
@@ -0,0 +1,1754 @@
+1
+00:00:20,740 --> 00:00:25,160
+بسم الله الرحمن الرحيم موضوعنا اليوم إن شاء الله
+
+2
+00:00:25,160 --> 00:00:30,620
+سيستمر في الـ rule-based expert systems ولكن تحت
+
+3
+00:00:30,620 --> 00:00:35,400
+عنوان آخر، اللي هو الـ uncertainty management في الـ
+
+4
+00:00:35,400 --> 00:00:40,400
+rule-based expert systems. فكرة عمل الـ expert
+
+5
+00:00:40,400 --> 00:00:45,800
+systems فهمناها كويس، وصار واضح أن الـ rules هي
+
+6
+00:00:45,800 --> 00:00:50,260
+المحور الأساسي للـ knowledge في الـ expert systems.
+
+7
+00:00:50,260 --> 00:00:55,580
+بس للأسف الشديد، وواقع الأمور يعني أنه مش دائماً الـ
+
+8
+00:00:55,580 --> 00:01:01,520
+rules بتبقى… بتبقى حتمية. يعني إيش حتمية؟ يعني إذا
+
+9
+00:01:01,520 --> 00:01:06,800
+كده، فإن كده حتمًا مئة بالمئة، تمام؟ أحيانًا يبقى فيه
+
+10
+00:01:06,800 --> 00:01:14,060
+نوع من عدم التأكد (uncertainty). إذا حدث كده، فممكن
+
+11
+00:01:14,060 --> 00:01:18,880
+يحدث كده، بس باحتمال most likely، يعني زي ما بنقول
+
+12
+00:01:18,880 --> 00:01:23,480
+مثلًا احتمال قوي جدًا، أو احتمال أقل شوية، فبيبقى فيه
+
+13
+00:01:23,480 --> 00:01:28,480
+إنه… بيبقى فيه درجة من عدم… عدم التأكد
+
+14
+00:01:28,480 --> 00:01:35,120
+في… أن هذا الشرط ينتج عنه هذه الـ conclusion. هذا
+
+15
+00:01:35,120 --> 00:01:38,300
+اللي هو اسمه uncertainty. uncertain لما أكون
+
+16
+00:01:38,300 --> 00:01:43,080
+certain، يعني أنا واثق تمامًا. uncertain يعني أنا مش
+
+17
+00:01:43,080 --> 00:01:48,000
+متأكد، أو مش واثق. وهذا شيء طبيعي في واقع الأمور، في
+
+18
+00:01:48,000 --> 00:01:52,200
+الحياة العملية، في كثير من التخصصات. لذلك لما بيجي
+
+19
+00:01:52,200 --> 00:01:57,580
+الـ human expert ما بيعطي rules certain rules، بيجي
+
+20
+00:01:57,580 --> 00:02:01,780
+بيعطي rules: "إن، والله، إذا تحقق الشرط، فهتتحقق
+
+21
+00:02:01,780 --> 00:02:07,020
+النتيجة بدرجة ثقة كده، okay". وهذا هو إطار
+
+22
+00:02:07,020 --> 00:02:11,020
+المحاضرة اليوم، إن شاء الله، هنتعامل مع موضوع الـ
+
+23
+00:02:11,020 --> 00:02:13,380
+uncertainty. المحاضرة هذه، والمحاضرة الجاية إن شاء
+
+24
+00:02:13,380 --> 00:02:17,300
+الله، المرة هذه باستخدام الـ certainty factors، و
+
+25
+00:02:17,300 --> 00:02:21,300
+المرة الجاية باستخدام الـ Bayesian rule.
+
+26
+00:02:22,610 --> 00:02:26,750
+فالكلام ده هيبقى منصب في المحاضرة هذه والمحاضرة
+
+27
+00:02:26,750 --> 00:02:31,190
+الجاية على الشابتر الثالث. موضوع الشابتر الثالث
+
+28
+00:02:31,190 --> 00:02:35,150
+اسمه uncertainty management in rule-based expert
+
+29
+00:02:35,150 --> 00:02:38,510
+systems. فيه طبعًا introduction، بعد هيك هو على طول
+
+30
+00:02:38,510 --> 00:02:43,370
+ببدأ بالـ basis، أنا هأبدأ من هنا، من
+
+31
+00:02:43,370 --> 00:02:46,310
+certainty factors theory، uncertainty factors
+
+32
+00:02:46,310 --> 00:02:50,690
+theory and evidential reasoning، لأنها أقرب أكثر
+
+33
+00:02:50,690 --> 00:02:53,290
+قربًا من الكلام اللي كنا بنحكيه في المحاضرة الماضية.
+
+34
+00:02:53,290 --> 00:02:56,970
+بعد ما يخلص الكلام هذا، برجع على الـ Bayesian
+
+35
+00:02:56,970 --> 00:03:00,290
+Reasoning. Bayesian Reasoning، okay. فكنت فاكر بقى
+
+36
+00:03:00,290 --> 00:03:03,790
+إحنا الآن، أن في المحاضرة هذه هنبدأ من تقريبًا من
+
+37
+00:03:03,790 --> 00:03:08,630
+هنا، من ثلاثة ستة، وعمليًا هيكون ترتيب الشرح تبعنا
+
+38
+00:03:08,630 --> 00:03:13,730
+ثلاثة ستة، بعدين هنشوف المثال هذا، اسمه forecast.
+
+39
+00:03:14,480 --> 00:03:19,100
+بعدين هذا كله في المحاضرة اليوم، بعدين في المحاضرة
+
+40
+00:03:19,100 --> 00:03:23,140
+الجاية بناخد الموضوع نفسه، اللي هو الـ uncertainty
+
+41
+00:03:23,140 --> 00:03:28,640
+بس من منطلق اللي هو الـ Bayesian reasoning. قبل ما
+
+42
+00:03:28,640 --> 00:03:32,780
+نحكي في الـ Bayesian reasoning، بحكي شوية في أساسيات
+
+43
+00:03:32,780 --> 00:03:37,400
+الـ probability theory. بعد كده بنشوف مثل نفسه، الـ
+
+44
+00:03:37,400 --> 00:03:41,580
+forecast، بس باستخدام الـ Bayesian accumulation of
+
+45
+00:03:41,580 --> 00:03:51,540
+evidence. بعد ذلك، يوجد هنا ملاحظات صغيرة، واحدة
+
+46
+00:03:51,540 --> 00:03:55,380
+هي الـ bias تبع الـ method، والثانية مقارنة ما بين
+
+47
+00:03:55,380 --> 00:03:59,620
+الطرقتين. الطريقتين للتعامل مع الـ uncertainty،
+
+48
+00:03:59,620 --> 00:04:06,240
+واحدة باستخدام الـ factors، والثانية باستخدام الـ
+
+49
+00:04:06,240 --> 00:04:13,040
+evidence. نبدأ اليوم بالـ Certainty Factors Theory.
+
+50
+00:04:13,040 --> 00:04:17,560
+بالبساطة الشديدة، بالـ Certainty Factors Theory،
+
+51
+00:04:17,560 --> 00:04:22,780
+إحنا بيكون في عندنا الـ rules زي ما بيتصار بالشكل
+
+52
+00:04:22,780 --> 00:04:27,060
+الاعتيادي، ولكن بيضاف إليها حاجة اسمها Certainty
+
+53
+00:04:27,060 --> 00:04:34,700
+Factor، قيمة عددية، عبارة عن number to measure الـ
+
+54
+00:04:34,700 --> 00:04:39,800
+expert’s belief، يعني درجة اعتقاد أو درجة ثقة الـ
+
+55
+00:04:39,800 --> 00:04:44,220
+human expert من صحة هذا الـ rule. صحة هذا الـ
+
+56
+00:04:44,220 --> 00:04:49,380
+rule، بمعنى أنه زي ما قلنا هو عارف أن الشرط هذا
+
+57
+00:04:49,380 --> 00:04:53,880
+بيؤدي إلى نتيجة هذه، بس مش حتمًا، مش مئة بالمئة، فيه
+
+58
+00:04:53,880 --> 00:04:58,900
+درجة من الـ maximum value of certainty factor، بيبدأ
+
+59
+00:04:58,900 --> 00:05:03,840
+ممكن plus one، والـ… نسميه definitely true، يعني
+
+60
+00:05:03,840 --> 00:05:07,580
+يبقى هو واثق مئة بالمئة. لما يقول لي الـ human
+
+61
+00:05:07,580 --> 00:05:10,520
+expert أن الـ rule هذه، الـ certainty factor تبعها
+
+62
+00:05:10,520 --> 00:05:15,620
+plus one، معناته إيش؟ هو واثق مئة بالمئة من
+
+63
+00:05:15,620 --> 00:05:20,480
+صحته، أن الـ rule true. إيش يعني الـ rule true؟ يعني
+
+64
+00:05:20,480 --> 00:05:25,660
+إذا تحقق هذا الشرط، حتمًا مئة بالمئة هيتحقق الـ
+
+65
+00:05:25,660 --> 00:05:29,330
+conclusion تبعته. الشرط هو الـ condition، والعكس من
+
+66
+00:05:29,330 --> 00:05:34,430
+ذلك، الـ minimum، بحط ناقص واحد، لما يكون هو: إذا تحقق
+
+67
+00:05:34,430 --> 00:05:40,270
+هذا الشرط، فحتمًا لن يتحقق هذا الـ conclusion، okay. فإذا
+
+68
+00:05:40,270 --> 00:05:47,410
+الـ expert بيقول أنه some evidence is almost
+
+69
+00:05:47,410 --> 00:05:52,530
+certainly true، ناشي؟ is almost certainly، كلمة
+
+70
+00:05:52,530 --> 00:05:55,870
+almost certainly، almost certainly، يعني مش
+
+71
+00:05:55,870 --> 00:06:00,520
+certainly مية في المية. almost، تقريبًا. هذه تقريبًا
+
+72
+00:06:00,520 --> 00:06:05,980
+خلتها مش واحد، خلتها ثمانية من عشرة. ثمانية من عشرة،
+
+73
+00:06:05,980 --> 00:06:10,260
+okay. فالكلمات هذه، almost certainly، لما بيجي هو الـ
+
+74
+00:06:10,260 --> 00:06:15,700
+human expert بيحكي: certainly، likely، probably، most
+
+75
+00:06:15,700 --> 00:06:19,500
+likely، حاجات زي هيك بتتحول إلى أرقام، تمام؟ بتتحول
+
+76
+00:06:19,500 --> 00:06:22,520
+إلى certainty factors. فهذا… هذا مثال. كلمة
+
+77
+00:06:22,520 --> 00:06:28,250
+definitely not، يعني قطعًا لن يحدث، أو قطعًا مش هيحدث،
+
+78
+00:06:28,250 --> 00:06:34,390
+هذا. فإذا الـ value of هذه الكلمة ناقص واحد، زي ما
+
+79
+00:06:34,390 --> 00:06:37,450
+اتفقنا، إن إحنا ناقص واحد لما نكون متأكدين في الـ
+
+80
+00:06:37,450 --> 00:06:42,010
+negative، متأكد أنه مش هيحدث، أن الـ conclusion مش
+
+81
+00:06:42,010 --> 00:06:46,010
+هتحدث. لما أكون متأكد أنها هتحدث، بتبقى positive
+
+82
+00:06:46,010 --> 00:06:50,610
+one. هي لما نقول definitely. إذا اليوم مطرت،
+
+83
+00:06:50,610 --> 00:06:57,570
+definitely بكرة هتمطر، تمام؟ عمرها ما كانت definite
+
+84
+00:06:57,570 --> 00:07:02,630
+بس بنقول: إذا حدث، وكان هو متأكد أن هذا هيترتب عليه
+
+85
+00:07:02,630 --> 00:07:06,790
+نتيجة، فبقول definitely، فبنعطيها plus one. ما بين definitely not و definitely، فيها الـ phrases هذه، أو
+
+86
+00:07:06,790 --> 00:07:10,230
+الـ clauses هذه. زي مثلًا لو بيقول لي almost certainly
+
+87
+00:07:10,230 --> 00:07:13,370
+not، أو لو بيقول لي almost certainly، زي ما تَبَقّى قلنا
+
+88
+00:07:13,370 --> 00:07:17,590
+ثمانية. لو بيقول لي unknown، فأنا مش عارف، مش عارف جدًا،
+
+89
+00:07:17,590 --> 00:07:22,990
+مش درجة موثوقية، أو درجة أثر هذا الشرط على هذه النتيجة،
+
+90
+00:07:22,990 --> 00:07:27,290
+بنعطيها إحنا قيمة عشوائية، من ناقص اثنين وعشرة إلى
+
+91
+00:07:31,590 --> 00:07:36,810
+زائد اثنين وعشرة، تمام؟ هذا الكلام فين بيجي بالظبط؟
+
+92
+00:07:36,810 --> 00:07:39,790
+في الـ expert system. الـ certainty factor فين بيجي؟
+
+93
+00:07:39,790 --> 00:07:44,110
+بيجي مع الـ rule، ببساطة شديدة. زي كإن نقول: if evidence،
+
+94
+00:07:44,110 --> 00:07:49,450
+then الـ hypothesis، الـ CF هتختصر لإيش؟ certainty
+
+95
+00:07:49,450 --> 00:07:55,890
+factor، تمام؟ هذا معناته أن الـ cf هذه represent الـ
+
+96
+00:07:55,890 --> 00:08:02,650
+belief، جدًّا جدًّا، درجة ثقة الـ human expert بأن الـ
+
+97
+00:08:02,650 --> 00:08:08,150
+hypothesis هيتحقق، given the evidence he has
+
+98
+00:08:08,150 --> 00:08:11,950
+occurred. hypothesis و evidence، أول مرة نسمع فيهم
+
+99
+00:08:11,950 --> 00:08:17,770
+مصطلحين هذه، صح؟ تمام، هم هذا الـ evidence، وهذا الـ
+
+100
+00:08:17,770 --> 00:08:18,190
+hypothesis.
+
+102
+00:08:22,150 --> 00:08:26,910
+نعتمد الآن مع الشرط، على أنه هو evidence، والـ
+
+103
+00:08:26,910 --> 00:08:31,490
+conclusion عليه hypothesis. هذا كلام قيل أصوله في
+
+104
+00:08:31,490 --> 00:08:35,870
+الـ Bayesian. لما نرجع، هتتضح أكثر دلوقت، بس الآن نأخذ
+
+105
+00:08:35,870 --> 00:08:40,070
+هم دول الـ two terms، على أنهم تسمية أخرى لإيش؟ الـ
+
+106
+00:08:40,070 --> 00:08:44,190
+condition والـ conclusion. بالظبط، من الـ evidence هو
+
+107
+00:08:44,190 --> 00:08:50,400
+الـ condition، والـ hypothesis هو الـ conclusion. فأنا
+
+108
+00:08:50,400 --> 00:08:52,900
+لما يقول لي الـ certainty factor، الـ certainty factor
+
+109
+00:08:52,900 --> 00:08:56,940
+هذه مرتبطة مش بالـ… مرتبطة بالـ rule كلها، أن هذه
+
+110
+00:08:56,940 --> 00:09:00,620
+الـ conclusion احتمالية، أنها ناتجة عن هذا الـ
+
+111
+00:09:00,620 --> 00:09:06,420
+condition، احتمالها CF كذا، okay. لأن نقول إن هذه الـ
+
+112
+00:09:06,420 --> 00:09:12,700
+certainty factor لأصولها في الـ probability theory،
+
+113
+00:09:12,700 --> 00:09:16,520
+وفي الـ Bayes rule. هذا الكلام يوضح إيش علاقة الـ
+
+114
+00:09:16,520 --> 00:09:21,520
+certainty factor بالـ higher probability، والـ
+
+115
+00:09:21,520 --> 00:09:24,380
+posterior probability. بس هذا الكلام إحنا من أجله
+
+116
+00:09:24,380 --> 00:09:31,300
+لِبَعْدِين. لما نرجع ثاني على الـ Bayesian Probability،
+
+117
+00:09:31,300 --> 00:09:33,540
+اللي أنا… إيش اللي بدنا نشوفه بالظبط؟ اللي أنا بدنا
+
+118
+00:09:33,540 --> 00:09:39,780
+نشوفه أنه… أنه كيف هذا الكلام، اللي هو الـ certainty
+
+119
+00:09:39,780 --> 00:09:44,380
+factor، بيأثر على الاستنتاج اللي إحنا بنستنتجه، و
+
+120
+00:09:44,380 --> 00:09:49,760
+اللي بناخذه بشكل نهائي من الـ expert system. لما أنا
+
+121
+00:09:49,760 --> 00:09:54,510
+بعطيه rules، وكل rule الآن صار مساحب لها certainty
+
+122
+00:09:54,510 --> 00:09:58,970
+factor، وبعدين بكبسله سؤال، بقوله: إيش احتمالية أنه
+
+123
+00:09:58,970 --> 00:10:03,570
+بكرة مثلًا تمطر، أو أي… أي سؤال اللي له علاقة بالـ
+
+124
+00:10:03,570 --> 00:10:08,110
+… بالمجال، بالتخصص، بالـ expert system، بيعطيني
+
+125
+00:10:08,110 --> 00:10:15,590
+استنتاج الآن، ولكن برضه كمان بيعطيني… بيعطيني
+
+126
+00:10:15,590 --> 00:10:19,750
+معاه أنه قد إيش هو كـ expert system واثق من هذا. هو
+
+127
+00:10:19,750 --> 00:10:23,330
+هيقلك: أنا أكيد أكيد أكيد أكيد أكيد أكيد أكيد
+
+128
+00:10:23,330 --> 00:10:24,130
+أكيد أكيد أكيد أكيد أكيد أكيد أكيد أكيد أكيد أكيد
+
+129
+00:10:24,130 --> 00:10:27,910
+أكيد أكيد أكيد أكيد أكيد أكيد أكيد أكيد أكيد أكيد
+
+130
+00:10:27,910 --> 00:10:28,670
+أكيد أكيد أكيد أكيد أكيد أكيد أكيد أكيد أكيد أكيد
+
+131
+00:10:28,670 --> 00:10:30,450
+أكيد أكيد أكيد أكيد أكيد أكيد أكيد أكيد أكيد أكيد
+
+132
+00:10:30,450 --> 00:10:36,790
+أكيد أكيد أكيد أكيد أكيد أكيد أكيد أكيد أكيد أكيد
+
+133
+00:10:36,790 --> 00:10:49,190
+أكيد أكيد أكيد أكيد
+
+134
+00:10:49,190 --> 00:10:55,770
+أَكْثَرُ then مبني على شرط، و
+
+135
+00:10:55,770 --> 00:11:00,630
+الشرط نفسه، جه استنتاج لهول سابقة. مش هذا ممكن يحصل،
+
+136
+00:11:00,630 --> 00:11:04,390
+مش ممكن يحصل، أن هذا الـ sky is clear، هذا يعني أحد
+
+137
+00:11:04,390 --> 00:11:07,670
+أحد المعلومات، أنا بعطيه إياها. بس حتى لما أعطيه
+
+138
+00:11:07,670 --> 00:11:11,150
+إياها، بقول له الـ sky is clear بنسبة كذا كذا. ممكن
+
+139
+00:11:11,150 --> 00:11:15,270
+تبقى فيه غيمة هنا ولا غيمة هنا. هو clear، السماء
+
+140
+00:11:15,270 --> 00:11:20,150
+صافية، بس في غيمتين. فأنا بقول له: sky is clear almost
+
+141
+00:11:20,150 --> 00:11:23,550
+clear، تمام؟ almost clear، هذه معناها تسعين في المية.
+
+142
+00:11:23,550 --> 00:11:27,930
+شو معنى ذلك؟ معنى ذلك، أن الشرط نفسه صار فيه نسبة
+
+143
+00:11:27,930 --> 00:11:34,190
+موثوقية. هذا هيأثر على الاستنتاج. لو هذا clear مئة في
+
+144
+00:11:34,190 --> 00:11:40,110
+المئة، يبقى الـ forecast، يعني تنبؤ الأحوال الجوية، أنه هيبدأ
+
+145
+00:11:40,110 --> 00:11:45,280
+الجو بكرة sunny باحتمال ثمانين في المية. لكن لو هذا
+
+146
+00:11:45,280 --> 00:11:54,900
+ما كانش 100%، لو أنا بقول على السماء، اجيتها 70% صافية،
+
+147
+00:11:54,900 --> 00:12:01,080
+أو 50% صافية، مش
+
+148
+00:12:01,080 --> 00:12:07,760
+هَيْأَثِّر على درجة قد إيش هو هيكون. مش صحيح، وكيف
+
+149
+00:12:07,760 --> 00:12:14,200
+ببساطة شديدة، فبنضرب الرقمين. فالـ certainty factor
+
+150
+00:12:19,590 --> 00:12:24,290
+إذا عُلِمَ الـ condition الفلاني، إذا تحقق الـ
+
+151
+00:12:24,290 --> 00:12:28,970
+condition فلاني، بيساوي الـ certainty factor تبع الـ
+
+152
+00:12:28,970 --> 00:12:35,850
+condition مضروب في الـ certainty factor تبع الـ rule.
+
+153
+00:12:35,850 --> 00:12:41,510
+فهذه الثمانية، الـ condition هي الـ evidence. مش تفاؤل
+
+154
+00:12:41,510 --> 00:12:47,640
+على ذلك. فأصبح الآن أنا الـ system، لازم يدخل في عملية
+
+155
+00:12:47,640 --> 00:12:52,860
+الـ inference حسب الـ certainty factors، وهذه قضية
+
+156
+00:12:52,860 --> 00:12:58,820
+بسيطة جدًا، اللي هي أنه يضرب عشان يطلع الـ conclusion.
+
+157
+00:12:58,820 --> 00:13:01,980
+لازم
+
+158
+00:13:01,980 --> 00:13:05,920
+يأخذ فعلًا اعتبار، كم كانت الـ certainty factors تبع الـ
+
+159
+00:13:05,920 --> 00:13:10,600
+condition، واضحة.
+
+160
+00:13:10,600 --> 00:13:14,720
+هذه العبارة إيش معناها؟ الـ certainty factor تبع هذا
+
+161
+00:13:14,720 --> 00:13:19,260
+الـ hypothesis، إذا عُلِمَ توفر هذا الـ evidence أو هذا
+
+162
+00:13:19,260 --> 00:13:23,780
+الـ condition، فهو يساوي الـ certainty factor تبع الـ
+
+163
+00:13:23,780 --> 00:13:26,700
+evidence مضروب في الـ certainty factor تبع… هنا الـ
+
+164
+00:13:26,700 --> 00:13:30,200
+certainty factor، مضروب هيك، بس المفهوم اللي قصد
+
+165
+00:13:30,200 --> 00:13:34,060
+فيه إنها إيش؟ الـ certainty factor تبع الـ rule، صح؟
+
+166
+00:13:34,060 --> 00:13:40,400
+okay. فهذا أول… أول تغيير بدي يحدث على عملية الـ
+
+167
+00:13:40,400 --> 00:13:45,480
+inference. التغيير الآخر، أنه افترض أن أنا عندي الـ
+
+168
+00:13:45,480 --> 00:13:52,520
+condition نفسه مركب، مركب من عدة sub conditions.
+
+169
+00:13:52,520 --> 00:13:58,840
+يعني هنا بقول لي: الـ action is wear sunglasses، البس
+
+170
+00:13:58,840 --> 00:14:02,420
+إذا كان الـ sky is clear and الـ forecast الصيني
+
+171
+00:14:02,420 --> 00:14:06,360
+يبقى بكرة جاهز حالك تاخد معاك sunglasses، اللي هي
+
+172
+00:14:06,360 --> 00:14:11,210
+نظارات شمسية. فإذا كان عندي الآن، عندي two conditions
+
+173
+00:14:11,210 --> 00:14:17,810
+إنه يتحقق، وبالنسبة مختلفة. كيف بدي أطلع النسبة
+
+174
+00:14:17,810 --> 00:14:27,090
+الموثوقية للـ conclusion؟ لأن
+
+175
+00:1
+
+223
+00:19:10,180 --> 00:19:14,520
+multiple rules بنسميه conflict وبناخد واحدة بس
+
+224
+00:19:14,520 --> 00:19:18,060
+بناخد واحدة at random هنا لما نكون في end
+
+225
+00:19:18,060 --> 00:19:21,480
+probability بناخدش واحدة بناخد combination من ال
+
+226
+00:19:21,480 --> 00:19:25,460
+two values بنحسب ال value تبع الـ C بناء على ال
+
+227
+00:19:25,460 --> 00:19:30,080
+rule الأولانية و ال value تبع الـ C بناء على ال
+
+228
+00:19:30,080 --> 00:19:35,960
+rule التانية و بناخد على أساسهم الـ ..بس أجيب ال
+
+229
+00:19:35,960 --> 00:19:44,340
+equation عشان بدنا equation رقم ايش؟ 32 هي
+
+230
+00:19:44,340 --> 00:19:48,220
+دلوقت تلاتين هي دلوقت تلاتين هي موجود فوق بس أنا
+
+231
+00:19:48,220 --> 00:19:59,520
+مش كاتب الرقم، اللي هو cf of أنا احنا ايش قلنا؟ في عندي
+
+232
+00:19:59,520 --> 00:20:08,980
+أنا rule واحد و rule اتنين بيقولوا واحد الـ cf تبع حجة
+
+233
+00:20:08,980 --> 00:20:12,060
+كم؟
+
+234
+00:20:12,060 --> 00:20:26,600
+الـ cf تبع rule اتنين يساوي كم؟ 0.6 الآن
+
+235
+00:20:26,600 --> 00:20:31,540
+في عيني أنا، الـ evidence one اللي هو
+
+236
+00:20:35,380 --> 00:20:43,040
+اللي هو أن a هو x و evidence two اللي هو أن b هو y
+
+237
+00:20:43,040 --> 00:20:50,240
+الاتنين متحققين، فأنا الآن أحسب الـ certainty factor
+
+238
+00:20:50,240 --> 00:20:59,160
+تبع c، الـ certainty factor تبع c given ايش؟ في حال
+
+239
+00:20:59,160 --> 00:21:03,300
+تحقق من الـ a، وبدي أحسب الـ certainty factor تبع c
+
+240
+00:21:03,300 --> 00:21:09,680
+في حال تحقق من الـ B، هذا ايش بيساوي؟ الـ certainty
+
+241
+00:21:09,680 --> 00:21:15,500
+factor تبع أول
+
+242
+00:21:15,500 --> 00:21:31,000
+الشيء تبع الـ A اللي هو E1 يعني
+
+243
+00:21:31,000 --> 00:21:37,940
+يعني هو هنا، بنقول إن الـ CF  وطبقة E1 وCF وطبقة
+
+244
+00:21:37,940 --> 00:21:48,780
+E2 متساوين، وكلها ما يساوي 1.0، أنا هذه عبارة عن ايش؟
+
+245
+00:21:48,780 --> 00:22:00,820
+هذا A هو E1 صح؟ وB هي E2 مش هيك؟ two evidences، فخلص
+
+246
+00:22:00,820 --> 00:22:08,720
+ببساطة 1.0 × 0.8 = 0.8، والتاني 1.0 × 0
+
+247
+00:22:08,720 --> 00:22:14,000
+.6 = 0.6، صار في عندي الآن two certainty
+
+248
+00:22:14,000 --> 00:22:20,220
+factors لـ C، الـ C بتوقع حدوثة، بس مرة بـ 80% و
+
+249
+00:22:20,220 --> 00:22:26,560
+مرة بـ 60%، فإيش بيساوي الـ formula هذه؟ تلاتة خمسة و
+
+250
+00:22:26,560 --> 00:22:31,540
+تلاتين بتقول إنه إذا كان certainty factors تبع الـ
+
+251
+00:22:31,540 --> 00:22:38,580
+two evidences CF1 و CF2، هل
+
+252
+00:22:38,580 --> 00:22:44,680
+CF1 تبع الـ evidence one و هل CF2 تبع الـ evidence
+
+253
+00:22:44,680 --> 00:22:50,800
+اتنين، إذا كانوا الاتنين أكبر من zero يعني positive
+
+254
+00:22:50,800 --> 00:22:59,290
+اتنين نفس الإشارة، اتنين موجبين، في هذه الحالة ببساطة
+
+255
+00:22:59,290 --> 00:23:08,850
+عشان إذا بأخد الـ cf1، الـ combine من cf1 مع cf2
+
+256
+00:23:08,850 --> 00:23:23,690
+يساوي cf1 + cf2 × (1 - cf1)، تمام؟ فأنا بأدمج
+
+257
+00:23:23,690 --> 00:23:27,610
+I combine الـ two certainty factors بالطريقة هذه
+
+258
+00:23:27,610 --> 00:23:30,750
+هذه الطريقة لو أنت أطلعت، أو هذه المعادلة لو أنت
+
+259
+00:23:30,750 --> 00:23:41,630
+أطلعت، هي نفسها هذه، إنما ايش؟ بدل الطرح جمع، هذه متى
+
+260
+00:23:41,630 --> 00:23:46,330
+بنستخدمها لما يكون الاتنين نفس الإشارة، بس negative
+
+261
+00:23:46,330 --> 00:23:51,160
+طبعا لما يكون عندي الـ two certainty factors CF1 و
+
+262
+00:23:51,160 --> 00:23:56,360
+CF2 متشابهين في الإشارة، بستخدم نفس الـ formula بس
+
+263
+00:23:56,360 --> 00:23:59,600
+اللي ما إلا في حالة ما يكونوا متشابهين، بستخدم
+
+264
+00:23:59,600 --> 00:24:04,200
+الناقص، وفي حالة ما يكونوا أقل من zero يعني سالب
+
+265
+00:24:04,200 --> 00:24:08,460
+بستخدم الـ plus، طب هي ده ايش معناه الكلام؟ الـ CF1
+
+266
+00:24:08,460 --> 00:24:17,880
+بسهولة، هي CF1، مظبوط؟ وهاد ايش؟ CF2، يعني معناه 0.8
+
+267
+00:24:17,880 --> 00:24:38,900
++ 0.6 × (1 - CF1) = 0.92
+
+268
+00:24:43,130 --> 00:24:48,590
+هذا درجة ثقتنا إنه الـ C سيحدث، إن الـ C is .. ايش؟
+
+269
+00:24:48,590 --> 00:24:57,190
+هو اللي بيقول هنا، ايش الـ rule بتقول؟ C is Z، عشان
+
+270
+00:24:57,190 --> 00:24:59,730
+كنت هأخذ النتيجة، لك ده عشان أختار الـ rule واحدة
+
+271
+00:24:59,730 --> 00:25:02,530
+اللي قُلتها، يعني لأ، ما بديش أختار الـ rule واحدة اللي
+
+272
+00:25:02,530 --> 00:25:07,970
+قُلت في الأول، في الأول كنا بنقول نختار الـ rule
+
+273
+00:25:07,970 --> 00:25:13,030
+بس هنا we combine، هنا في الـ under uncertainty عندما
+
+274
+00:25:13,030 --> 00:25:18,330
+يكون هناك فرصة غير متأكدة، نجمع نتيجة rule واحد مع
+
+275
+00:25:18,330 --> 00:25:22,370
+نتيجة rule اتنين، واضحة الفكرة الأساسية هنا، هناك
+
+276
+00:25:22,370 --> 00:25:27,630
+نجمع، ندمج، هذا rule الأولى طلعت لي 80% و rule التانية
+
+277
+00:25:27,630 --> 00:25:32,250
+طلعت لي 60%، أنا لن آخذ واحد من الاثنين، لن آخذ
+
+278
+00:25:32,250 --> 00:25:36,610
+واحد وأستثني الأخرى، لأ، حتى لو تلاتة سآخذهم كمان
+
+279
+00:25:36,610 --> 00:25:42,920
+سآخذهم وأدمجهم بالطريقة هذه، بالألية، أدمجهم، طلع، أما
+
+280
+00:25:42,920 --> 00:25:45,640
+أنا دمجت تمانين وستين في المية، وستين في
+
+281
+00:25:45,640 --> 00:25:52,140
+المية، ايش طلع معايا؟ 92%، زادت، صح؟ زادت، زادت درجة
+
+282
+00:25:52,140 --> 00:25:55,600
+الموثوقية من هذا الاستنتاج، هذا هو الاستنتاج
+
+283
+00:25:55,600 --> 00:25:59,380
+الاثنين، استنتاجوا لي نفس الناتج، الاثنين اللي قالوا لي
+
+284
+00:25:59,380 --> 00:26:04,830
+أن C ستكون Z، المتغير الـ c سيكون الـ value تبعه
+
+285
+00:26:04,830 --> 00:26:07,490
+الذات، وهذا برضه بتقول إن المتغير الـ c سيكون الـ
+
+286
+00:26:07,490 --> 00:26:10,990
+value تبعه الذات، بس واحدة بتقول لي نسبة ثقتها من
+
+287
+00:26:10,990 --> 00:26:17,490
+كلامها 60%، والتانية ثقتها من كلامها 80%، طب أنا آخذ
+
+288
+00:26:17,490 --> 00:26:21,070
+مين؟ هآخذهم الاثنين، بس هدمجهم، ويطلع معايا رقم جديد
+
+289
+00:26:21,070 --> 00:26:26,190
+الرقم معايا 92، أعلى من الـ 80%، وأعلى من الـ 60%، صح؟
+
+290
+00:26:26,190 --> 00:26:31,630
+تخيل الأمر كأنه اثنين قاعدين بيشهدوا أو بيؤكدوا
+
+291
+00:26:31,630 --> 00:26:36,610
+حقيقة، تمام؟ أنا بسأل فلان، بقوله: هل شفت المدرس اليوم
+
+292
+00:26:36,610 --> 00:26:40,170
+أجي على الجامعة؟ بقولي: آه، متأكد؟ بقولي: آه
+
+293
+00:26:40,170 --> 00:26:43,430
+متأكد، قد ايش متأكد؟ تمانين في المية، تمام؟ هذا في حد
+
+294
+00:26:43,430 --> 00:26:47,670
+ذاته كويس، لما يجي واحد ثاني أسأله، بقوله: شفت
+
+295
+00:26:47,670 --> 00:26:54,870
+المدرس أجي على الجامعة؟ بقولي: آه، بقوله: قد ايش؟ متأكد
+
+296
+00:26:54,870 --> 00:27:00,790
+بيقولي 60%، الآن 60% صحيح أضعف من 80%، ولكن كونها
+
+297
+00:27:00,790 --> 00:27:07,710
+اثنين، اثنين شهادتين لنفس المعلومة، هذا يقوي درجة
+
+298
+00:27:07,710 --> 00:27:11,850
+ثقتي أنا إنه فعلا المعلومة صحيحة، مظبوط؟ ونفس
+
+299
+00:27:11,850 --> 00:27:16,270
+الأشياء، لو كان بـ negative، هتلاقي إن الرقم اللي
+
+300
+00:27:16,270 --> 00:27:22,220
+طلع هيبدأ عالي بس بـ negative، okay؟ يعني دمج حصل
+
+301
+00:27:22,220 --> 00:27:26,040
+دمج الشهادتين، هذي شهادة، وهذي شهادة، حصل دمج
+
+302
+00:27:26,040 --> 00:27:33,080
+الشهادتين، آه، هيطلع أعلى من أي من هما، وهيبقى في
+
+303
+00:27:33,080 --> 00:27:40,940
+الإشارة، يعني لو المتناقضتين، لو واحد بيقول 80%
+
+304
+00:27:40,940 --> 00:27:45,960
+بالموجب، والتاني بيقول 60% بالسالب، يبقى الاثنين
+
+305
+00:27:45,960 --> 00:27:52,300
+بتضعفوا في بعض، واحد بيشهد ضد الشهادة، مناقضة شهادة
+
+306
+00:27:52,300 --> 00:27:57,560
+الأخرى، الـ rules بنفضوا بعض، يبقى بأخد ..
+
+307
+00:27:57,560 --> 00:28:02,420
+يبقى .. لما نحدد أحسن اسم لهذه اللي هي الحالة
+
+308
+00:28:02,420 --> 00:28:05,220
+الرسالة ده، هو التلات حالات، الحالة الأولى أن
+
+309
+00:28:05,220 --> 00:28:09,260
+الاثنين positive، صح؟ الحالة التالتة أن الاثنين
+
+310
+00:28:09,260 --> 00:28:12,800
+negative، صح؟ هذه واحدة منهم positive، والتاني
+
+311
+00:28:12,800 --> 00:28:19,880
+negative، صح؟ في هذه الحالة هيطلع معايا قيمة أضعف من
+
+312
+00:28:19,880 --> 00:28:25,410
+أي منهم، يعني الموجب هتكون أضعف، والسالب هتكون أضعف
+
+313
+00:28:25,410 --> 00:28:30,990
+صح؟ خلّيني أطلع هذا الكلام في الحالة هذه، في الحالة
+
+314
+00:28:30,990 --> 00:28:35,330
+هذه اللي أمامنا في الـ example هذا، مافيه أن الـ
+
+315
+00:28:35,330 --> 00:28:40,410
+certainty factor تبع الـ evidence الأولاني موجب
+
+316
+00:28:40,410 --> 00:28:43,270
+واحد، بينما الـ certainty factor تبع الـ evidence
+
+317
+00:28:43,270 --> 00:28:46,830
+الثاني سالب واحد، أدخل الكلام هذا في المعادلة
+
+318
+00:28:46,830 --> 00:28:51,820
+هيطلع لك الـ rule، هيتطلع لك الـ certain factor، الـ CF1
+
+319
+00:28:51,820 --> 00:28:58,680
+اللي هو الاستنتاج بناء على rule رقم واحد، موجب تمانية
+
+320
+00:28:58,680 --> 00:29:03,940
+موجب تمانية، صح؟ الاستنتاج بناء على rule رقم اثنين
+
+321
+00:29:03,940 --> 00:29:07,880
+هينقص ستة، في هذه الحالة ما أقدرش أطبق نفس الـ
+
+322
+00:29:07,880 --> 00:29:12,420
+formula لا هذه ولا الثانية، طبعا، لازم أطبق الـ
+
+323
+00:29:12,420 --> 00:29:18,200
+formula الأخرى اللي هي هذه، اللي هي أن أجمعهم
+
+324
+00:29:18,200 --> 00:29:18,640
+الاثنين
+
+325
+00:29:23,310 --> 00:29:28,390
+على واحد ناقص الـ minimum ما بينهم، الـ minimum
+
+326
+00:29:28,390 --> 00:29:33,930
+absolute value بعد ما أشيل الإشارة، يعني تمانية و
+
+327
+00:29:33,930 --> 00:29:38,430
+ناقص ستة، اللي
+
+328
+00:29:38,430 --> 00:29:42,210
+هو ايش؟ ايش الـ minimum؟ شيلت أنا الإشارة تبع
+
+329
+00:29:42,210 --> 00:29:48,150
+الستة، الـ minimum تبعهم، ناقص ستة، الـ 0.6 زي ما يعني
+
+330
+00:29:48,150 --> 00:29:57,740
+يعني 1 - 0.6 = 0.4، كلام هذا فوق؟
+
+331
+00:29:57,740 --> 00:30:01,780
+مجموعهم، مجموعهم، طبعا واحد منهم هتكون اشارتها سالب
+
+332
+00:30:01,780 --> 00:30:11,140
+صح؟ فبيطلع 0.2، هذا نص هذا، صح؟ هذا 0.2، نص 0.4، ايش رأيك
+
+333
+00:30:11,140 --> 00:30:16,500
+في الرقم هذا؟ الرقم هذا أقل من الـ 8%، وفي نفس الوجهة
+
+334
+00:30:16,500 --> 00:30:21,160
+أعلى من الـ 0.6، صح؟
+
+335
+00:30:23,760 --> 00:30:30,720
+أجالي مانيش ضعيف
+
+336
+00:30:30,720 --> 00:30:36,260
+ضعيف ضعيف ضعيف
+
+337
+00:30:36,260 --> 00:30:41,000
+ضعيف ضعيف ضعيف
+
+338
+00:30:41,000 --> 00:30:41,860
+ضعيف ضعيف ضعيف ضعيف ضعيف ضعيف ضعيف ضعيف ضعيف ضعيف ضعيف
+
+339
+00:30:41,860 --> 00:30:52,700
+ضعيف ضعيف ضعيف ضعيف
+
+340
+00:30:52,700 --> 00:30:56,430
+ضعيف، وبعدين، ما نديش نأخذ مع الـ system تلاتة، أكتر من
+
+341
+00:30:56,430 --> 00:31:03,630
+evidence، قلنا minimum و maximum، إذا نفس الـ rule
+
+342
+00:31:03,630 --> 00:31:08,270
+فيها أكتر من evidence، إذا هم conjunction أو
+
+343
+00:31:08,270 --> 00:31:16,110
+disjunction، بتأخذ، صح؟ احنا الآن أصبح عندنا هالـ
+
+344
+00:31:16,110 --> 00:31:21,660
+الآلية أو الآليات اللازمة
+
+345
+00:31:21,660 --> 00:31:28,820
+لمعالجة الـ rules في حالة الـ uncertainty، أول آلية
+
+346
+00:31:28,820 --> 00:31:34,320
+كانت أن الاستنتاج تبع الـ rule، بنأخذه زي ما هو
+
+347
+00:31:34,320 --> 00:31:37,560
+بالثقة، أولا أولا أولا، احنا بنضيف certainty factor
+
+348
+00:31:37,560 --> 00:31:43,900
+للـ rules، فهذا أول حاجة استجدت عن كلامنا السابق، أنه
+
+349
+00:31:43,900 --> 00:31:46,160
+صار الـ rule لها certainty factor
+
+350
+00:31:49,070 --> 00:31:52,950
+هذا الكلام ترتب عليه أنه أنا الاستنتاج تبع رئيس
+
+351
+00:31:52,950 --> 00:31:58,770
+الدولة دي تحققت، استنتاج تبعها بدي آخذ الـ certainty
+
+352
+00:31:58,770 --> 00:32:01,470
+factor تبعها، وأضربه في الـ certainty factor تبع
+
+353
+00:32:01,470 --> 00:32:06,270
+مين؟ الـ evidence، مظبوط؟ عشان آخذ الـ certainty
+
+354
+00:32:06,270 --> 00:32:12,130
+factor تبع الاستنتاج، هذا الموضوع معناه ده،
+
+355
+00:32:12,130 --> 00:32:16,520
+مظبوط؟ القضية التالتة اللي هي لما يكون في عندي
+
+356
+00:32:16,520 --> 00:32:21,860
+multiple evidence في ذاك الـ rule الواحدة، لاستخدام
+
+357
+00:32:21,860 --> 00:32:25,880
+الـ minimum أو الـ maximum، القضية الرابعة، النقطة
+
+358
+00:32:25,880 --> 00:32:29,000
+الرابعة اللي هي إنه لما يكون في عندي more than one
+
+359
+00:32:29,000 --> 00:32:31,120
+rule، تمام؟
+
+360
+00:32:32,910 --> 00:32:36,790
+more than one rule بتعطي نفس الاستنتاج، ولكن بـ
+
+361
+00:32:36,790 --> 00:32:41,430
+certain t factors متباينة، نفس الاستنتاج اللي هو c
+
+362
+00:32:41,430 --> 00:32:45,710
+is z، ولكن بـ certain t factors مختلفة، كيف بتعامل
+
+363
+00:32:45,710 --> 00:32:50,490
+معاهم؟ بتعامل معاهم حسب إذا هم الاثنين موجبين أو
+
+364
+00:32:50,490 --> 00:32:54,990
+اثنين سالبين أو بيختلفوا عن بعض، تمام؟ الـ example
+
+365
+00:32:54,990 --> 00:33:02,120
+اللي بنطلع عليه الآن بشكل عملي أكتر، اللي هو Express
+
+366
+00:33:02,120 --> 00:33:08,340
+System، بسيط جدا، rule based فيه بس الستة rules هدولة
+
+367
+00:33:08,340 --> 00:33:13,320
+أطلع عليهم
+
+368
+00:33:13,320 --> 00:33:19,600
+هو
+
+369
+00:33:19,600 --> 00:33:23,320
+about a forecast، لتنبؤ أو لتوقع حالة إتجاه Express
+
+370
+00:33:23,320 --> 00:33:29,390
+System is required to predict whether whether it
+
+371
+00:33:29,390 --> 00:33:33,370
+will rain tomorrow، or in other words to establish
+
+372
+00:33:33,370 --> 00:33:36,890
+certain factors for the not valid object tomorrow
+
+373
+00:33:36,890 --> 00:33:41,970
+هذا الآن tomorrow، ايش سماه؟ object، تذكره linguistic
+
+374
+00:33:41,970 --> 00:33:46,950
+variables و linguistic objects، تمام؟ فهو عبارة عن
+
+375
+00:33:46,950 --> 00:33:52,610
+متغير، متغيره ايه؟ هو، القيمة تبعته هتكون اما rain أو
+
+376
+00:33:52,610 --> 00:33:58,310
+dry، أو ايش؟ Rain or Dry، بالظبط، إنه يا اما هتمطر يا
+
+377
+00:33:58,310 --> 00:34:02,670
+أما مش هتمطر، بس الآن في عندي certainty factor، الـ
+
+378
+00:34:02,670 --> 00:34:09,510
+certainty factors تبع الرموز المختلفة، الآن ايش
+
+379
+00:34:09,510 --> 00:34:12,490
+بتوقع أن الـ system عشان يشتغل، بعد ما نعطيه الرموز
+
+380
+00:34:12,490 --> 00:34:18,470
+هذا، يساوي بده يشتغل بـ forward chaining أو backward
+
+381
+00:34:18,470 --> 00:34:18,950
+chaining
+
+382
+00:34:22,130 --> 00:34:26,010
+هيبدأ .. إذا .. إذا هو بدي .. الـ system بدي أفترض
+
+383
+00:34:26,010 --> 00:34:30,790
+أنه بكرا dry، معناه ذلك ايش؟ بدي يبدأ يسألني عن الـ
+
+384
+00:34:30,790 --> 00:34:34,810
+ايش؟ المعطيات اللي بدي .. آه، وين فيه rule بتقول لي
+
+385
+00:34:34,810 --> 00:34:38,110
+dry، هيجي يقول لي: هل today is dry؟ هيسألني السؤال
+
+386
+00:34:38,110 --> 00:34:42,010
+هذا إذا بدي أمشي forward، forward sharing، هيمسك الـ
+
+387
+00:34:42,010 --> 00:34:47,550
+rules، ويشوف ايش في عنده معطيات، لسه ما فيش معطيات، فإيش
+
+388
+00:34:47,550 --> 00:34:51,090
+بيسوي؟ حيسأل الـ user، هيقول له: ايش بتتوقع؟ ايش
+
+389
+00:34:51,090 --> 00:34:56,830
+اليوم الحالة؟ تمام؟ فهيكون عن طريق الـ dialogue
+
+390
+00:34:56,830 --> 00:35:00,910
+طبعا، what is the weather today؟ فالـ user بيقول له
+
+391
+00:35:00,910 --> 00:35:07,570
+rain، تمام؟ فبناء على ذلك، الـ
+
+445
+00:40:02,550 --> 00:40:06,410
+rule التاني، الـ rule رقم تلاتة بتستنتج الاستنتاج
+
+446
+00:40:06,410 --> 00:40:07,430
+آخر ويقوله
+
+447
+00:40:14,200 --> 00:40:20,320
+هذا الكلام كيف نتعامل معه؟ هل... هذا إيش هذا...
+
+448
+00:40:20,320 --> 00:40:24,760
+هذا الآن الـ... الـ... الـ conclusion بتعطي... الـ
+
+449
+00:40:24,760 --> 00:40:29,040
+system بيعطي two facts بيقول لي أن tomorrow رح
+
+450
+00:40:29,040 --> 00:40:33,910
+يكون رين، أو two predictions سيقول لي أنه سيكون رين
+
+451
+00:40:33,910 --> 00:40:36,870
+وفي نفس الوقت سيقول لي أنه سيكون dry، بس بالنسبة
+
+452
+00:40:36,870 --> 00:40:45,490
+المتفاوتة، هل الآن نعمل combination؟ ندمج؟
+
+453
+00:40:45,490 --> 00:40:52,390
+هاي tomorrow وهاي tomorrow، لأ
+
+454
+00:40:52,390 --> 00:40:58,190
+ما ندمجش، إحنا ندمج لما تكون نفس الـ fact أو نفس الـ
+
+455
+00:40:58,190 --> 00:41:00,720
+conclusion، بالنسبة للمتفاوتة، بس هنا two conclusions
+
+456
+00:41:00,720 --> 00:41:06,180
+طب مش هتساوي في هذه الحالة؟ باخدها عادة، ممكن الـ
+
+457
+00:41:06,180 --> 00:41:12,060
+system يعطيني two recommendations، يقول لي هتكون
+
+458
+00:41:12,060 --> 00:41:19,880
+مطرة، وبرضه يقول لي هتكون جافة، اه ممكن، ممكن لسه
+
+459
+00:41:19,880 --> 00:41:26,060
+متفاوتة، إذا الأمر، المعطيات ما بتساهم على أنه نحسم
+
+460
+00:41:26,550 --> 00:41:32,510
+فبيظل الأمر عائم بين الهدف، جدّام، لو في الدورة اللي
+
+461
+00:41:32,510 --> 00:41:35,450
+بعد، في الـ cycle اللي بعد، الـ system سأل سؤال
+
+462
+00:41:35,450 --> 00:41:40,410
+وعطيناه إجابة، والإجابة هذه هتكون لها دور في ترجيح
+
+463
+00:41:40,410 --> 00:41:44,590
+كفة أحد التوقعات
+
+464
+00:41:44,590 --> 00:41:51,090
+على الآخر، بعد ذلك الـ system سأل what is the
+
+465
+00:41:51,090 --> 00:41:53,990
+temperature؟ يعني أنه الآن أنت فاكر فيها forward
+
+466
+00:41:53,990 --> 00:41:57,930
+shading، الـ system قاعد يلف ويدور على إيش فيه rules
+
+467
+00:41:57,930 --> 00:42:01,710
+عنده، ومين منهم fired، هذه كانت الأولى والثالثة
+
+468
+00:42:01,710 --> 00:42:04,810
+already fired، لأنه يريد أن يشوف هل في المزيد كان
+
+469
+00:42:04,810 --> 00:42:08,590
+fired ولا لأ، بس المزيد هذا بيعتمد على معطيات، إذا
+
+470
+00:42:08,590 --> 00:42:12,490
+وقفنا على rule، والـ rule هذه فيها شق ما عندناش
+
+471
+00:42:12,490 --> 00:42:18,560
+المعلومة اللي بعتمد عليها، نسأل الـ user what is the
+
+472
+00:42:18,560 --> 00:42:21,900
+temperature today، سأل عن الـ temperature، قال
+
+473
+00:42:21,900 --> 00:42:24,000
+له to what degree do you believe that the
+
+474
+00:42:24,000 --> 00:42:29,380
+temperature is cold، قال له تسعة في المئة، الآن هذا
+
+475
+00:42:29,380 --> 00:42:33,880
+كان أصلاً السؤال اللي جه، لأنه كان مقفل في الـ chain
+
+476
+00:42:33,880 --> 00:42:36,780
+اللي، على الرغم من الرقم 4، فسأل عن الـ temperature
+
+477
+00:42:36,780 --> 00:42:42,260
+وسأل عن قد إيش درجة الثقة إنها cold، فالآن في عند
+
+478
+00:42:42,260 --> 00:42:48,430
+هنا two أو تلاتة evidences، evidence الأولى يعني
+
+479
+00:42:48,430 --> 00:42:54,210
+Today's
+
+480
+00:42:54,210 --> 00:42:57,810
+rain، هذا عندنا، وعندنا الإيجاب تبعته، وعندنا الـ
+
+481
+00:42:57,810 --> 00:43:00,970
+certainty تبعته، هذا rainfall اللي هو عندنا، وعندنا
+
+482
+00:43:00,970 --> 00:43:05,810
+الـ certainty تبعته، هذا اللي استجد، وصار عندنا، وصار
+
+483
+00:43:05,810 --> 00:43:10,450
+الـ certainty تبعته قد إيش؟ كده كانت 0.9، فالآن برضه
+
+484
+00:43:10,450 --> 00:43:16,650
+لأنهم end، فبناخد الـ minimum، الـ minimum بين الواحد
+
+485
+00:43:16,650 --> 00:43:23,190
+والتسعة، وأيضاً إيش اللي قبل؟ مش كان تسعة؟ الثمانية صح؟
+
+486
+00:43:23,190 --> 00:43:27,730
+الثمانية تبعت اللي هو rainfall، واحد، والثمانية، و
+
+487
+00:43:27,730 --> 00:43:30,730
+التسعة، إيش الـ minimum؟ اللي هي الثمانية، بتنضرر في
+
+488
+00:43:30,730 --> 00:43:34,870
+سبعة، بلاش ستة وخمسين، الآن ستة وخمسين، tomorrow is
+
+489
+00:43:34,870 --> 00:43:41,850
+dry، صح؟ tomorrow is dry، صارت ستة وخمسين، وكانت
+
+490
+00:43:41,850 --> 00:43:43,630
+ثمانية وأربعين، وكانت ثمانية وأربعين
+
+491
+00:43:48,940 --> 00:43:53,440
+اللي هو compound، بالظبط، بتعمل combination ولا مش
+
+492
+00:43:53,440 --> 00:43:59,840
+شادة؟ لأ، لسه، لسه، تمام
+
+493
+00:43:59,840 --> 00:44:05,360
+إيه، الآن صار في عندي أن rule تلاتة، وrule أربعة
+
+494
+00:44:05,360 --> 00:44:09,980
+rule تلاتة اللي قالت لي أنه dry، ثمانية وأربعين، هذا
+
+495
+00:44:09,980 --> 00:44:15,920
+الكلام جه من rule، وهذا الكلام أنه rain جه من
+
+496
+00:44:16,510 --> 00:44:20,890
+الآن استجد علينا rule ستة، تجعلني أقول أن اليوم هو
+
+497
+00:44:20,890 --> 00:44:30,570
+dry، بس بالنسبة... صح؟ فهنا دول الآن الـ
+
+498
+00:44:30,570 --> 00:44:35,370
+conclusion هي نفسها، بس بـ two different what؟ بـ two
+
+499
+00:44:35,370 --> 00:44:39,210
+different certainty values، صح؟ الآن أنا لازم أعمل
+
+500
+00:44:39,210 --> 00:44:45,290
+compilation، هنا الـ certainty factor الإجمالي
+
+501
+00:44:46,030 --> 00:44:49,070
+من الـ rule تلاتة، من الـ certainty factor تبقى الـ
+
+502
+00:44:49,070 --> 00:44:50,550
+rule تلاتة، من الـ certainty factor تبقى الـ rule
+
+503
+00:44:50,550 --> 00:44:55,090
+أربعة، إيش هم بيستخدموا الآن أي formula؟ لأنهم
+
+504
+00:44:55,090 --> 00:44:58,690
+الاتنين موجبين، فبيستخدموا الـ formula اللي كنا نحكي
+
+505
+00:44:58,690 --> 00:45:04,050
+عنها، اللي هي الأول زائد الثاني مضروباً في واحد ناقص الأول
+
+506
+00:45:04,050 --> 00:45:11,690
+فطلع 0.77، شايف كيف عززوا بعض، الـ two certainties
+
+507
+00:45:11,690 --> 00:45:17,350
+أو uncertainties، عززوا بعض، فزادت الاحتمالية أنه
+
+508
+00:45:17,350 --> 00:45:31,830
+صار عندي 0.77، هذا الـ combined، صرت أنا أكثر
+
+509
+00:45:31,830 --> 00:45:39,100
+للاعتقاد أنه تكون dry، الآن الـ system بيستمر في
+
+510
+00:45:39,100 --> 00:45:44,100
+القاعلية هذه، بيستمر في القاعلية هذه إلى أن ما يظلش
+
+511
+00:45:44,100 --> 00:45:50,120
+فيه rules اللي يمكن مطابقتها، إيش يعني؟ أن هم هدول
+
+512
+00:45:50,120 --> 00:45:55,780
+الـ 6 rules، خليني أرجع لهم، الآن هدول الـ 6 rules
+
+513
+00:45:55,780 --> 00:46:00,060
+خلاص استنفذ الـ... إيش المعطيات اللي، أو استنفذت الـ
+
+514
+00:46:00,060 --> 00:46:04,240
+conditions بتاعتها، ما ضلش في شيء اللي يمكن مطابقته
+
+515
+00:46:05,090 --> 00:46:11,650
+كوني قلت لي أن اليوم رين، يبقى ما فيش مجال أنه هادي
+
+516
+00:46:11,650 --> 00:46:18,890
+...خلي بالك أن اليوم مطر، اجت من وين؟ اجت... اجت
+
+517
+00:46:18,890 --> 00:46:22,750
+نتيجة... نتيجة الاستنتاج هذا تبع... تبع الرقم
+
+518
+00:46:22,750 --> 00:46:31,390
+تلاتة، مش أنا اللي قلت له أن tomorrow، مش أنا اللي
+
+519
+00:46:31,390 --> 00:46:36,410
+قلت له، مش أنا اللي قلت له، هو استنتج الاستنتاجات، rule
+
+520
+00:46:36,410 --> 00:46:39,510
+ستة هذه اللي اتولدت فيها، أو rule أربعة، آسف أنا
+
+521
+00:46:39,510 --> 00:46:43,970
+أخطأت، rule أربعة، rule أربعة ده بقول كيف اجت اليوم جمال
+
+522
+00:46:43,970 --> 00:46:48,150
+جمال اليوم is rain، و rainfall is low، و temperature
+
+523
+00:46:48,150 --> 00:46:51,710
+is cold، هدول كلهم اجوا من، ليش؟ من المعطيات اللي
+
+524
+00:46:51,710 --> 00:46:58,130
+أعطيتها اليوم، فبنقول إذا كان لازال في rules أخرى
+
+525
+00:46:58,130 --> 00:47:04,390
+يمكن مطابقتها، وممكن تقديرها بـ effects، بيستمر غير
+
+526
+00:47:04,390 --> 00:47:10,330
+كبير، جف، وبيعطيني هذه الأرقام، منها اليه؟ اليه اللي
+
+527
+00:47:10,330 --> 00:47:15,090
+ما فيه بوابتها، بس هو قال لي اليوم مدهش هادي، خلاص
+
+528
+00:47:15,090 --> 00:47:18,130
+هادي مدهش هادي، اه، وبعدين كمان temperature
+
+529
+00:47:18,130 --> 00:47:21,290
+temperature اللي أنا قلت له أن الـ temperature is
+
+530
+00:47:21,290 --> 00:47:25,950
+low، فخلاص هادي كيف ده تصير true، رقم خمسة
+
+531
+00:47:28,580 --> 00:47:32,240
+الكلام هنا عن tomorrow، tomorrow هو اللي dry، أنا
+
+532
+00:47:32,240 --> 00:47:36,480
+حسّمت الـ rule رقم خمسة لأني طلعت برة الموضوع من
+
+533
+00:47:36,480 --> 00:47:41,860
+الزاوية، ما قلت له today is rain، صح؟
+
+534
+00:47:41,860 --> 00:47:49,780
+أصبح ما فيش مجال أن هذا تتحقق، لأن today is dry، وستة
+
+535
+00:47:49,780 --> 00:47:52,600
+كذا مش هتتحقق، نعم، طلعت برة
+
+536
+00:47:58,890 --> 00:48:05,390
+هذا باختصار شديد يعني، اللي هو فحوى الـ certainty
+
+537
+00:48:05,390 --> 00:48:09,310
+factor theory
+
+538
+00:48:09,310 --> 00:48:15,270
+و قاعدية تطبيقه في الـ rule based expert system
+
+539
+00:48:15,270 --> 00:48:21,110
+الحلقة القادمة بنحكي في الـ Bayesian rule
+
+540
+00:48:21,110 --> 00:48:25,070
+وكيف يمكن توظيفها في الـ rule based expert system
diff --git a/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/HLgYDIGhP90_raw.srt b/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/HLgYDIGhP90_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..9afc572fdb54ba34b202dc326e116123c644b5d0
--- /dev/null
+++ b/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/HLgYDIGhP90_raw.srt
@@ -0,0 +1,2200 @@
+1
+00:00:20,740 --> 00:00:25,160
+بسم الله الرحمن الرحيم موضوعنا اليوم ان شاء الله
+
+2
+00:00:25,160 --> 00:00:30,620
+بيستمر في ال rule-based expert systems ولكن تحت
+
+3
+00:00:30,620 --> 00:00:35,400
+عنوان آخر اللي هو ال uncertainty management في ال
+
+4
+00:00:35,400 --> 00:00:40,400
+rule-based expert systems فكرة قلية عمل ال expert
+
+5
+00:00:40,400 --> 00:00:45,800
+systems احنا فهمناها كويسوصار واضح ان ال rules هي
+
+6
+00:00:45,800 --> 00:00:50,260
+المحور الأساسي لل knowledge في ال express systems
+
+7
+00:00:50,260 --> 00:00:55,580
+بس للأسف شديد وواقع الأمور يعني انه مش دايما ال
+
+8
+00:00:55,580 --> 00:01:01,520
+rules بتبقى .. بتبقى حتمية يعني إيش حتمية يعني إذا
+
+9
+00:01:01,520 --> 00:01:06,800
+كده فإن كده حتما مائة بالمائة تمام؟ أحيانا يبقى في
+
+10
+00:01:06,800 --> 00:01:14,060
+نوع من عدم التأكد uncertaintyإذا حدث كده فممكن
+
+11
+00:01:14,060 --> 00:01:18,880
+يحدث كده بس باحتمال most likely يعني زي ما بنقول
+
+12
+00:01:18,880 --> 00:01:23,480
+مثلا احتمال قوي جدا او احتمال اقل شوية فببقى فيه
+
+13
+00:01:23,480 --> 00:01:28,480
+انه .. ببقى فيه انه درجة من عدم ال .. عدم التأكد
+
+14
+00:01:28,480 --> 00:01:35,120
+في .. انه هذا الشرط ينتج عنه هذه ال conclusionفهذا
+
+15
+00:01:35,120 --> 00:01:38,300
+اللي هو اسمه uncertainty uncertain لما انا اكون
+
+16
+00:01:38,300 --> 00:01:43,080
+certain ان انا واثق تماما uncertain يعني انا مش
+
+17
+00:01:43,080 --> 00:01:48,000
+متأكد او مش واثق وهذا شئ طبيعي في واقع الأمور في
+
+18
+00:01:48,000 --> 00:01:52,200
+الحياة العملية في كثير من التخصصات لذلك لما بيجي
+
+19
+00:01:52,200 --> 00:01:57,580
+ال human expertما بيعطي rules certain rules بيجي
+
+20
+00:01:57,580 --> 00:02:01,780
+بيعطي rules ان و الله ايه تتحقق الشرط فهتتحقق
+
+21
+00:02:01,780 --> 00:02:07,020
+النتيجة بدرجة منثوقية كده okay وهذا هو اطار
+
+22
+00:02:07,020 --> 00:02:11,020
+المحاضرة اليوم ان شاء الله هنتعامل مع موضوع ال
+
+23
+00:02:11,020 --> 00:02:13,380
+uncertainty المحاضرة هذه و المحاضرة الجاية ان شاء
+
+24
+00:02:13,380 --> 00:02:17,300
+الله المرة هذه باستخدام ال certainty factors و
+
+25
+00:02:17,300 --> 00:02:21,300
+المرة الجاية باستخدام ال Bayesian rule
+
+26
+00:02:22,610 --> 00:02:26,750
+فالكلام ده هيبقى منصب في المحاضرة هذه والمحاضرة
+
+27
+00:02:26,750 --> 00:02:31,190
+الجاية على الشارتر التالت موضوع الشارتر التالت
+
+28
+00:02:31,190 --> 00:02:35,150
+اسمه uncertainty management in rule-based express
+
+29
+00:02:35,150 --> 00:02:38,510
+systems فيه طبعا introduction بعد هيك هو على طول
+
+30
+00:02:38,510 --> 00:02:43,370
+ببدأ بال base بالباسيا انا هابدأ من هنا من
+
+31
+00:02:43,370 --> 00:02:46,310
+certainty factors theory uncertainty factors
+
+32
+00:02:46,310 --> 00:02:50,690
+theory and evidential reasoningلأنها أقرب اكتر
+
+33
+00:02:50,690 --> 00:02:53,290
+قربا من الكلام اللى كنا بنحكيه في المحاضرة الماضية
+
+34
+00:02:53,290 --> 00:02:56,970
+بعد ما خلص الكلام هذا برجع على ال Bayesian
+
+35
+00:02:56,970 --> 00:03:00,290
+Reasoning Bayesian Reasoning okay فكنت فاكر بقى
+
+36
+00:03:00,290 --> 00:03:03,790
+احنا الآن ان في المحاضرة هذه هنبدأ من تقريبا من
+
+37
+00:03:03,790 --> 00:03:08,630
+هنا من تلاتة ستة وعمليا هيكون ترتيب الشرح تبعنا
+
+38
+00:03:08,630 --> 00:03:13,730
+تلاتة ستة بعدين هنشوف المثال هذا اسمه forecast
+
+39
+00:03:14,480 --> 00:03:19,100
+بعدين هذا كله في المحاضرة اليوم بعدين في المحاضرة
+
+40
+00:03:19,100 --> 00:03:23,140
+الجاية بناخد الموضوع نفسه اللي هو ال uncertainty
+
+41
+00:03:23,140 --> 00:03:28,640
+بس من منطلق اللي هو ال Bayesian reasoning قبل ما
+
+42
+00:03:28,640 --> 00:03:32,780
+نحكي في ال Bayesian reasoning بحكي شوية في أساسيات
+
+43
+00:03:32,780 --> 00:03:37,400
+ال probability theory بعد كده بنشوف مثل نفسه ال
+
+44
+00:03:37,400 --> 00:03:41,580
+forecast بس باستخدام ال Bayesian accumulation of
+
+45
+00:03:41,580 --> 00:03:51,540
+evidenceبعد ذلك يوجد هنا ملاحظات صغيرة واحدة
+
+46
+00:03:51,540 --> 00:03:55,380
+هي ال bias تبع ال method والثانية مقارنة ما بين
+
+47
+00:03:55,380 --> 00:03:59,620
+الطريقتين الطريقتين للتعامل مع ال uncertainty
+
+48
+00:03:59,620 --> 00:04:06,240
+واحدة باستخدام ال factors والثانية باستخدام ال
+
+49
+00:04:06,240 --> 00:04:13,040
+evidenceنبدأ اليوم بالـ Certainty Factors Theory
+
+50
+00:04:13,040 --> 00:04:17,560
+بالبساطة الشديدة بالـ Certainty Factors Theory
+
+51
+00:04:17,560 --> 00:04:22,780
+احنا بيكون في عندنا ال rules زي ما يتصار بالشكل
+
+52
+00:04:22,780 --> 00:04:27,060
+الاعتيادي ولكن بيضاف اليها حاجة اسمها Certainty
+
+53
+00:04:27,060 --> 00:04:34,700
+Factor قيمة عددية عبارة عن number to measure ال
+
+54
+00:04:34,700 --> 00:04:39,800
+experts beliefيعني درجة اعتقاد او درجة وثوق ال
+
+55
+00:04:39,800 --> 00:04:44,220
+human expert من هذه من صحة هذا ال role صحة هذا ال
+
+56
+00:04:44,220 --> 00:04:49,380
+role بمعنى انه زي ما قلنا هو عارف ان الشرط هذا
+
+57
+00:04:49,380 --> 00:04:53,880
+بيؤدي الى نتيجة هذه بس مش حتما مش مائة بالمائة فيه
+
+58
+00:04:53,880 --> 00:04:58,900
+درجة من ال maximum value of certain factor بيبدأ
+
+59
+00:04:58,900 --> 00:05:03,840
+ممكن plus oneو ال .. نسميه definitely true يعني
+
+60
+00:05:03,840 --> 00:05:07,580
+يبقى هو واثق مائة بالمائة لما يقولي ال human
+
+61
+00:05:07,580 --> 00:05:10,520
+expert ان ال rule هذه ال certainty factor تبعها
+
+62
+00:05:10,520 --> 00:05:15,620
+plus one معناته هو ايش؟ هو واثق مائة بالمائة من
+
+63
+00:05:15,620 --> 00:05:20,480
+صحته ان ال rule true ايش يعني ال rule true؟ يعني
+
+64
+00:05:20,480 --> 00:05:25,660
+اذا تحقق هذا الشرط حتما مائة بالمائة هيتحقق ال
+
+65
+00:05:25,660 --> 00:05:29,330
+conclusion تبعته الشرط هو ال conditionوالعكس من
+
+66
+00:05:29,330 --> 00:05:34,430
+ذلك ال minimum بحط نقص واحد لما يكون هو إذا اتحقق
+
+67
+00:05:34,430 --> 00:05:40,270
+هذا شرط فحتما لن يتحقق هذا ال conclusion okay فإذا
+
+68
+00:05:40,270 --> 00:05:47,410
+ال expert بيقول أنه some evidence is almost
+
+69
+00:05:47,410 --> 00:05:52,530
+certainly true ناشي؟ is almost certainly كلمة
+
+70
+00:05:52,530 --> 00:05:55,870
+almost certainly almost certainly يعني مش
+
+71
+00:05:55,870 --> 00:06:00,520
+certainly مية في الميةalmost تقريباً هذه تقريباً
+
+72
+00:06:00,520 --> 00:06:05,980
+خلته مش واحد خلته تمانية في المية تمانية من عشرة
+
+73
+00:06:05,980 --> 00:06:10,260
+okay فالكلمات هذه almost certainly لما بيجي هو ال
+
+74
+00:06:10,260 --> 00:06:15,700
+human expert بيحكي certainly likely probably most
+
+75
+00:06:15,700 --> 00:06:19,500
+likely حاجات زي هيكة بتتحول إلى أرقام تمام بتتحول
+
+76
+00:06:19,500 --> 00:06:22,520
+إلى certainty factors فهذا هذا مثال كلمة
+
+77
+00:06:22,520 --> 00:06:28,250
+definitely not يعني قطعا لنيحدث أو قطعا مش هيحدث
+
+78
+00:06:28,250 --> 00:06:34,390
+هذا فإذا ال value of هذه الكلمة ناقص واحد زي ما
+
+79
+00:06:34,390 --> 00:06:37,450
+اتفرج ان احنا ناقص واحد لما نكون متأكد في ال
+
+80
+00:06:37,450 --> 00:06:42,010
+negative متأكد انه مش هيحدث ان ال conclusion مش
+
+81
+00:06:42,010 --> 00:06:46,010
+هتحدث لما اذا متأكد انها هتحدث ماتبجعش positive
+
+82
+00:06:46,010 --> 00:06:50,610
+one هي لما نقول definitely إذا اليوم مطرت
+
+83
+00:06:50,610 --> 00:06:57,570
+definitely بكرا هتمطر تمامعمرها ما كانت definite
+
+84
+00:06:57,570 --> 00:07:02,630
+بس بنقول إذا حدث و كان هو متأكد أن هذا هيترتب عليه
+
+85
+00:07:02,630 --> 00:07:06,790
+نتيجة فبقول definitely فبنعطيها plus one ما بين it
+
+86
+00:07:06,790 --> 00:07:10,230
+definitely not و definitely فيها ال phrases هذه أو
+
+87
+00:07:10,230 --> 00:07:13,370
+ال clauses هذه زي مثلا لو بيقولي almost certainly
+
+88
+00:07:13,370 --> 00:07:17,590
+not أو لو بيقولي almost certainly زي ما تبقى قولنا
+
+89
+00:07:17,590 --> 00:07:22,990
+تمانية لو بيقولي unknown فانا مش عارفمش عارف جداش
+
+90
+00:07:22,990 --> 00:07:27,290
+درجة موثوقية أو درجة أثر هذا الشرط على هذه النتيجة
+
+91
+00:07:27,290 --> 00:07:31,590
+نعطيها احنا قيمة عشوائية من نقص اتنين و عشرة إلى
+
+92
+00:07:31,590 --> 00:07:36,810
+زائر اتنين و عشرة تمام هذا الكلام وين بيجي بالظبط
+
+93
+00:07:36,810 --> 00:07:39,790
+في ال express system ال certainty factor وين بيجي
+
+94
+00:07:39,790 --> 00:07:44,110
+بيجي مع ال rule ببساطة شديدة زيك نقول if evidence
+
+95
+00:07:44,110 --> 00:07:49,450
+then ال hypothesis ال CF هتختصر لإيش certainty
+
+96
+00:07:49,450 --> 00:07:55,890
+factor تمامهذا معناته ان الـ cf هذي represent ال
+
+97
+00:07:55,890 --> 00:08:02,650
+belief جداش جداش درجة وثوق ال human expert بإن ال
+
+98
+00:08:02,650 --> 00:08:08,150
+hypothesis هيتحقق given the evidence he has
+
+99
+00:08:08,150 --> 00:08:11,950
+occurred hypothesis و evidence أول مرة نسمع فيهم
+
+100
+00:08:11,950 --> 00:08:17,770
+مصطلحين هذا صح تمام هم هذا ال evidence وهذا ال
+
+101
+00:08:17,770 --> 00:08:18,190
+hypothesis
+
+102
+00:08:22,150 --> 00:08:26,910
+نتقام الآن مع الشرط على أنه هو evidence و ال
+
+103
+00:08:26,910 --> 00:08:31,490
+conclusion عليها hypothesis هذا كلام قيله أصوله في
+
+104
+00:08:31,490 --> 00:08:35,870
+ال Bayesian لما نرجع هتتضح لها دلوقت بس الآن ناخد
+
+105
+00:08:35,870 --> 00:08:40,070
+هم دول ال two terms على أنهم تسمية أخرى لإيش ال
+
+106
+00:08:40,070 --> 00:08:44,190
+condition و ال conclusion بالظبط من ال evidence هو
+
+107
+00:08:44,190 --> 00:08:50,400
+ال conditionوالـ hypothesis هو ال conclusion فانا
+
+108
+00:08:50,400 --> 00:08:52,900
+لما يقوللي ال certainty factor ال certainty factor
+
+109
+00:08:52,900 --> 00:08:56,940
+هذه مرتبطة مش بال .. مرتبطة بال role كلها ان هذه
+
+110
+00:08:56,940 --> 00:09:00,620
+ال conclusion احتمالي انها تمتش نتيجة هذا ال
+
+111
+00:09:00,620 --> 00:09:06,420
+condition احتمالها CF كذا okayلأن نقولتي إن هذه ال
+
+112
+00:09:06,420 --> 00:09:12,700
+certainty factor لأصولها في ال probability theory
+
+113
+00:09:12,700 --> 00:09:16,520
+و في ال Bayes rule هذا الكلام يوضح أيش علاقة ال
+
+114
+00:09:16,520 --> 00:09:21,520
+certainty factor بال higher probability و ال
+
+115
+00:09:21,520 --> 00:09:24,380
+posterior probability بس هذا الكلام احنا من أجله
+
+116
+00:09:24,380 --> 00:09:31,300
+لبعدينلما نرجع تاني على ال Bayesian Probability
+
+117
+00:09:31,300 --> 00:09:33,540
+اللي انا ايش اللي بدنا نشوفه بالظبط اللي انا بدنا
+
+118
+00:09:33,540 --> 00:09:39,780
+نشوفه انه انه كيف هذا الكلام اللي هو ال certainty
+
+119
+00:09:39,780 --> 00:09:44,380
+factor بيأثر على الاستنتاج اللي احنا بنستنتجه و
+
+120
+00:09:44,380 --> 00:09:49,760
+اللي بناخده بشكل نهائي من ال expert system لما انا
+
+121
+00:09:49,760 --> 00:09:54,510
+بعطيلهrules وكل rule الان صار مساحب الها certainty
+
+122
+00:09:54,510 --> 00:09:58,970
+factor و بعدين كبسأله سؤال بقوله ايش احتمالية انه
+
+123
+00:09:58,970 --> 00:10:03,570
+بكرا مثلا تمطر او اي .. اي سؤال اللي له علاقة بال
+
+124
+00:10:03,570 --> 00:10:08,110
+.. بالمجال التخصص بال express system بيعطيني
+
+125
+00:10:08,110 --> 00:10:15,590
+استنتاج الان ولكن برضه كمان بيعطيني معاه بيعطيني
+
+126
+00:10:15,590 --> 00:10:19,750
+معاه انه جداش هو ك express system واثق من هذاهو
+
+127
+00:10:19,750 --> 00:10:23,330
+سيقول لك انا اكيد اكيد اكيد اكيد اكيد اكيد اكيد
+
+128
+00:10:23,330 --> 00:10:24,130
+اكيد اكيد اكيد اكيد اكيد اكيد اكيد اكيد اكيد اكيد
+
+129
+00:10:24,130 --> 00:10:27,910
+اكيد اكيد اكيد اكيد اكيد اكيد اكيد اكيد اكيد اكيد
+
+130
+00:10:27,910 --> 00:10:28,670
+اكيد اكيد اكيد اكيد اكيد اكيد اكيد اكيد اكيد اكيد
+
+131
+00:10:28,670 --> 00:10:28,670
+اكيد اكيد اكيد اكيد اكيد اكيد اكيد اكيد اكيد اكيد
+
+132
+00:10:28,670 --> 00:10:30,450
+اكيد اكيد اكيد اكيد اكيد اكيد اكيد اكيد اكيد اكيد
+
+133
+00:10:30,450 --> 00:10:36,790
+اكيد اكيد اكيد اكيد اكيد اكيد اكيد اكيد اكيد اكيد
+
+134
+00:10:36,790 --> 00:10:49,190
+اكيد اكيد اكيد اكيد
+
+135
+00:10:49,190 --> 00:10:55,770
+اكthen مبني على شرط و
+
+136
+00:10:55,770 --> 00:11:00,630
+الشرط نفسه أجى استنتاج لهول سابقة مش هذا ممكن يحصل
+
+137
+00:11:00,630 --> 00:11:04,390
+مش ممكن يحصل ان هذا ال sky is clear هذا يعني احد
+
+138
+00:11:04,390 --> 00:11:07,670
+ذات معلومة انا بعطيله اياها بس حتى لما اعطيله
+
+139
+00:11:07,670 --> 00:11:11,150
+اياها بقوله ال sky is clear بنسبة كده كده ممكن
+
+140
+00:11:11,150 --> 00:11:15,270
+تبقى فيه غيمة هنا ولا غيمة هنا هو clear السماء
+
+141
+00:11:15,270 --> 00:11:20,150
+صافيةبس في غمتين فانا بقول له sky is clear almost
+
+142
+00:11:20,150 --> 00:11:23,550
+clear تمام almost clear هذه معناه تسعين في المية
+
+143
+00:11:23,550 --> 00:11:27,930
+شو معناه ذلك؟ معناه ذلك ان الشرط نفسه صار فيه نسبة
+
+144
+00:11:27,930 --> 00:11:34,190
+موثقية هذا هيأثر على الاستنتاج لو هذا clear مية في
+
+145
+00:11:34,190 --> 00:11:40,110
+المية يبقى ال forecast يعني تنبؤ الأجساد انه هيبدأ
+
+146
+00:11:40,110 --> 00:11:45,280
+الجو بكرة sunny باحتمال تمانين في الميةلكن لو هذا
+
+147
+00:11:45,280 --> 00:11:54,900
+ماكنش 100% لو أنا بقلع على السما لاجيتها 70% صافية
+
+148
+00:11:54,900 --> 00:12:01,080
+او 50% صافية مش
+
+149
+00:12:01,080 --> 00:12:07,760
+بدي أثر على درجة جداش هو هيكون مش مسجوب و كده كيف
+
+150
+00:12:07,760 --> 00:12:14,200
+ببساطة شديدة فبنضرب الرقمين فال certainty factor
+
+151
+00:12:19,590 --> 00:12:24,290
+إذا عُلم ال condition الفلاني إذا تحقق ال
+
+152
+00:12:24,290 --> 00:12:28,970
+condition فلاني بساوي ال certainty factor تبع ال
+
+153
+00:12:28,970 --> 00:12:35,850
+condition مضروب في ال certainty factor تبع ال rule
+
+154
+00:12:35,850 --> 00:12:41,510
+فهذه التمانية ال condition هي ال evidence مش تفاجن
+
+155
+00:12:41,510 --> 00:12:47,640
+على ذلكفأصبح الآن أنا ال system لازم يدخل في عملية
+
+156
+00:12:47,640 --> 00:12:52,860
+ال inference حسب ال certainty factors وهذه قضية
+
+157
+00:12:52,860 --> 00:12:58,820
+بسيطة جدا اللي هي أنه يضرب عشان يطلع ال conclusion
+
+158
+00:12:58,820 --> 00:13:01,980
+لازم
+
+159
+00:13:01,980 --> 00:13:05,920
+يخد فعلا أتبار كم كانت ال certainty factors تبع ال
+
+160
+00:13:05,920 --> 00:13:10,600
+condition واضحة
+
+161
+00:13:10,600 --> 00:13:14,720
+هذه العبارة أيش معناتهاالـ certainty factor تبع هل
+
+162
+00:13:14,720 --> 00:13:19,260
+ال hypothesis إذا غُلم توفر هذا ال evidence أو هذا
+
+163
+00:13:19,260 --> 00:13:23,780
+ال condition فهو يساوي ال certainty factor تبع ال
+
+164
+00:13:23,780 --> 00:13:26,700
+evidence مضروف ال certainty factor تبع .. هنا ال
+
+165
+00:13:26,700 --> 00:13:30,200
+certainty factor مضروف كهيكة بس المفهوم اللي قصد
+
+166
+00:13:30,200 --> 00:13:34,060
+فيه إنها إياش ال certainty factor تبع ال role صح؟
+
+167
+00:13:34,060 --> 00:13:40,400
+okay فهذا أول .. أول تغيير بدي يحدث على عملية ال
+
+168
+00:13:40,400 --> 00:13:45,480
+inferenceالتغيير الآخر انه افترض ان انا اندي ال
+
+169
+00:13:45,480 --> 00:13:52,520
+condition نفسه مركب مركب من عدة sub conditions
+
+170
+00:13:52,520 --> 00:13:58,840
+يعني هنا بقول لي ال action is wear sunglasses إلبس
+
+171
+00:13:58,840 --> 00:14:02,420
+إذا كان ال sky is clear and ال forecast الصيني
+
+172
+00:14:02,420 --> 00:14:06,360
+يبقى بكرة جاهز حالك تاخد معاك sunglasses اللي هي
+
+173
+00:14:06,360 --> 00:14:11,210
+نظرات شمسيةفإذا كان على الان اهندي two conditions
+
+174
+00:14:11,210 --> 00:14:17,810
+انه يتحقق و بالنسبة مختلفة كيف بدي أطلع النسبة
+
+175
+00:14:17,810 --> 00:14:27,090
+الموثقية لل conclusion لأن
+
+176
+00:14:27,090 --> 00:14:32,490
+انت إذا كانت انت باخد الأقل منهم يعني افترض هذا
+
+177
+00:14:32,490 --> 00:14:35,610
+كان 0.5 و هذا كان 0.9
+
+178
+00:14:37,940 --> 00:14:44,520
+والتالي 0.7 المقال هو 0.7 اللي بتنضرب في ال 0.8
+
+179
+00:14:44,520 --> 00:14:56,100
+تبع ال rule صح؟ فبطلع اللي هو 0.56 فإذا كان عندي
+
+180
+00:14:56,100 --> 00:14:58,900
+أنا في الحالة اللي أمامنا اللي أمام ال express
+
+181
+00:14:58,900 --> 00:15:05,020
+system ان ال sky is clear بنسبة 90% و ال forecast
+
+182
+00:15:05,020 --> 00:15:09,630
+is sunnyهم بيقولولي بتوقع أنه بكرا يكون sunny
+
+183
+00:15:09,630 --> 00:15:15,850
+بنسبة ال 70% فيمعنى ذلك أقرر .. عشان أقرر أخد
+
+184
+00:15:15,850 --> 00:15:19,330
+معايا sunglasses ولا لأ بدي أطلع على النسبة هذه
+
+185
+00:15:19,330 --> 00:15:24,190
+يعني .. يعني الكلب بيقوللي اخد و ماتاخدش جريبة من
+
+186
+00:15:24,190 --> 00:15:28,150
+ال fifty fifty يعني صح هذا if it can end و if it
+
+187
+00:15:28,150 --> 00:15:33,920
+can't or بتتوقع ايش يكون اكس يكون ال maxmultiple
+
+188
+00:15:33,920 --> 00:15:37,140
+evidences اي واحد اتنين دول يعني اصحاب conditions
+
+189
+00:15:37,140 --> 00:15:43,900
+زمان وبالتالي باخد ال maximum ما بينهم و بضربه في
+
+190
+00:15:43,900 --> 00:15:47,480
+ال certainty factor تبع الhypothesis او ال pool
+
+191
+00:15:47,480 --> 00:15:53,700
+فهذا ال net certainty factor for multiple
+
+192
+00:15:53,700 --> 00:15:57,020
+antecedents انتسدنت يعني ليه conditions
+
+193
+00:16:00,150 --> 00:16:08,430
+multiple antecedent rules مربوطين
+
+194
+00:16:08,430 --> 00:16:11,630
+مع بعض بيش او متصلين مع بعض بال disjoint او ال or
+
+195
+00:16:11,630 --> 00:16:14,890
+طبعا ممكن تبقى ال condition فيه خليط من ال and و
+
+196
+00:16:14,890 --> 00:16:18,530
+ال or ولو لأ بس خلاص منطقي جدا ان و الله اذا في
+
+197
+00:16:18,530 --> 00:16:25,970
+هنا مجموع ال conditions and و بعدين في or و هنا
+
+198
+00:16:25,970 --> 00:16:30,140
+مجموع ال conditionsباخد الصحفي تبع هدولة و ال end
+
+199
+00:16:30,140 --> 00:16:35,260
+و الصحفي تبع هدولة و باخدهم بعد ذلك O و بحسب
+
+200
+00:16:35,260 --> 00:16:39,480
+الحسبة على هذا الاساس طيب
+
+201
+00:16:39,480 --> 00:16:46,040
+هذا طبعا اللي هي نفس مثال تبع ال .. ال .. ال
+
+202
+00:16:46,040 --> 00:16:50,180
+disjunction ال O بس ماعطينا الأرقام هي هنا ال sky
+
+203
+00:16:50,180 --> 00:16:58,690
+is overcast ستين في الميل و ال forecast is rain80%
+
+204
+00:16:58,690 --> 00:17:03,570
+مين اللي انا اخد اللي انا اخد ال 80% و نضربها في
+
+205
+00:17:03,570 --> 00:17:10,270
+90% تبع ال hypothesis طيب
+
+206
+00:17:10,270 --> 00:17:16,350
+احيانا ديش اللي واجهنا انه two rules fire ايش يعني
+
+207
+00:17:16,350 --> 00:17:22,670
+two rules fire يعني تنتين قفلة التنتين جالك
+
+208
+00:17:22,670 --> 00:17:25,770
+بيقولوا ليه التنتين ال condition تبعهم two
+
+209
+00:17:25,770 --> 00:17:33,290
+والتنتينالنتيجة تبعتهم بتصبح في نفس المتغير يعني
+
+210
+00:17:33,290 --> 00:17:39,350
+هنا A كانت ال true فهذا ال role fires و B كانت ال
+
+211
+00:17:39,350 --> 00:17:42,770
+true فهذا ال role أيضا fires فعندي أنا بناء على
+
+212
+00:17:42,770 --> 00:17:48,910
+هذا ال role هيطلع معايا C تساوي Z بنسبة وهنا تطلع
+
+213
+00:17:48,910 --> 00:17:52,030
+معايا بنسبة مختلفة صح ولا لأ
+
+214
+00:18:02,510 --> 00:18:11,510
+تمام اكواجين E32 دعوني اكتب على اللوح باربرا موجود
+
+215
+00:18:11,510 --> 00:18:16,550
+هنا اكتب
+
+216
+00:18:16,550 --> 00:18:29,370
+اكواجين
+
+217
+00:18:29,370 --> 00:18:31,690
+E32 من الكتاب
+
+218
+00:18:41,390 --> 00:18:44,830
+الان بدك تفكر في ان كيف نتعامل مع هذا الوضع ان في
+
+219
+00:18:44,830 --> 00:18:49,570
+ادي two rules fire و terrain بيعطوني استنتاجات
+
+220
+00:18:49,570 --> 00:18:56,990
+مختلفة لنفس المتغير C هذا لو استخدمت rule رقم واحد
+
+221
+00:18:56,990 --> 00:19:01,370
+هيطلع درجة الموثوقية عليه كذا و بينما لو استخدمت
+
+222
+00:19:01,370 --> 00:19:06,510
+rule اتنين يطلع قيمة مختلفة ايش نسوي احنا طبعا
+
+223
+00:19:07,040 --> 00:19:10,180
+إتفاقنا قبل أيه كإنه في ال .. في ال .. لما تبقى في
+
+224
+00:19:10,180 --> 00:19:14,520
+multiple rules بنسميه conflict وبناخد واحدة بس
+
+225
+00:19:14,520 --> 00:19:18,060
+بناخد واحدة at random هنا لما نكون في end
+
+226
+00:19:18,060 --> 00:19:21,480
+probability بناخدش واحدة بناخد combination من ال
+
+227
+00:19:21,480 --> 00:19:25,460
+two values بنحسب ال value تبع ال C بناء على ال
+
+228
+00:19:25,460 --> 00:19:30,080
+rule الأولانية و ال value تبع ال C بناء على ال
+
+229
+00:19:30,080 --> 00:19:35,960
+rule التانية و بناخد على أساسهم ال ..بس اجيب ال
+
+230
+00:19:35,960 --> 00:19:44,340
+equation عشان بدنا equation رقم ايش 32 هي
+
+231
+00:19:44,340 --> 00:19:48,220
+دلوقت تلاتين هي دلوقت تلاتين هي موجود فوق بس انا
+
+232
+00:19:48,220 --> 00:19:59,520
+مش كاتب الرقم الهي cf of انا احنا ايش قلنا في عندي
+
+233
+00:19:59,520 --> 00:20:08,980
+انا rule واحد و rule اتنينيقول واحد ال cf تبع حجة
+
+234
+00:20:08,980 --> 00:20:12,060
+كم؟
+
+235
+00:20:12,060 --> 00:20:26,600
+ال cf تبع رول اتنين يسوى كم؟ 0.6 الان
+
+236
+00:20:26,600 --> 00:20:31,540
+في عيني انا ال evidence one اللي هو
+
+237
+00:20:35,380 --> 00:20:43,040
+اللي هو ان a هو x و evidence two اللي هو ان b هو y
+
+238
+00:20:43,040 --> 00:20:50,240
+الاتنين متحققين فانا الأن احسب ال certainty factor
+
+239
+00:20:50,240 --> 00:20:59,160
+تبع c ال certainty factor تبع c given ايش في حال
+
+240
+00:20:59,160 --> 00:21:03,300
+تحقق من ال a و بدي أحسب ال certainty factor تبع c
+
+241
+00:21:03,300 --> 00:21:09,680
+في حال تحقق منالـ B هذا ايش بيساوي ال certainty
+
+242
+00:21:09,680 --> 00:21:15,500
+factor تبع اول
+
+243
+00:21:15,500 --> 00:21:31,000
+الشيء تبع ال A اللي هو E1 يعني
+
+244
+00:21:31,000 --> 00:21:37,940
+يعني هو هنابقول إن الاتنين CF وطبقة E1 وCF وطبقة
+
+245
+00:21:37,940 --> 00:21:48,780
+E2 متساوين وكلها ما يساوي 1.0 انا هذه عبارة عن ايش
+
+246
+00:21:48,780 --> 00:22:00,820
+هذا A هو E1 صح وB هي E2 مش هيك two evidencesفخلص
+
+247
+00:22:00,820 --> 00:22:08,720
+ببساطة 1.0 ضارب 0.8 بيساوي 0.8 والتاني 1.0 ضارب 0
+
+248
+00:22:08,720 --> 00:22:14,000
+.6 بيساوي 0.6 صار في عندي الان two certainty
+
+249
+00:22:14,000 --> 00:22:20,220
+factors لسه ال C ال C بتوقع حدوثة بس مرة بيه 80% و
+
+250
+00:22:20,220 --> 00:22:26,560
+مرة بيه 60% فإيش بيسوي ال formula هذه تلاتة خمسة و
+
+251
+00:22:26,560 --> 00:22:31,540
+تلاتين بتقول إنه إذا كانcertainty factors تبع ال
+
+252
+00:22:31,540 --> 00:22:38,580
+two evidences CF1 و CF2 هل
+
+253
+00:22:38,580 --> 00:22:44,680
+CF1 تبع ال evidence one و هل CF2 تبع ال evidence
+
+254
+00:22:44,680 --> 00:22:50,800
+اتنين اذا كانوا الاتنين اكبر من zero يعني positive
+
+255
+00:22:50,800 --> 00:22:59,290
+اتنين نفس الاشارة اتنين مجابين في هذا الحالةبساطة
+
+256
+00:22:59,290 --> 00:23:08,850
+عشان اذا باخد الـ cf1 الـ combine من cf1 مع cf2
+
+257
+00:23:08,850 --> 00:23:23,690
+يساوي cf1 زائد cf2 مضروبا في 1-cf1 تمام فانا بادمج
+
+258
+00:23:23,690 --> 00:23:27,610
+I combineالـ two certainty factors بالطريقة هذه
+
+259
+00:23:27,610 --> 00:23:30,750
+هذه الطريقة لو انت اتطلعت أو هذه المعادلة لو انت
+
+260
+00:23:30,750 --> 00:23:41,630
+اتطلعت هي نفسها هذه انما ايش بلد الطرح جمع هذه متى
+
+261
+00:23:41,630 --> 00:23:46,330
+بنستخدمها لما يكون الاتنين نفس الإشارة بس negative
+
+262
+00:23:46,330 --> 00:23:51,160
+طبعا لما يكون عند ال two certainty factorsCF1 و
+
+263
+00:23:51,160 --> 00:23:56,360
+CF2 متشابهين في الإشارة بستخدم نفس ال formula بس
+
+264
+00:23:56,360 --> 00:23:59,600
+الله ما إلا في حالة ما يكونوا متشابهين بستخدم
+
+265
+00:23:59,600 --> 00:24:04,200
+الناقص و في حالة ما يكونوا أقل من zero يعني و سالب
+
+266
+00:24:04,200 --> 00:24:08,460
+بستخدم ال plus طب هي ده إيش معناته الكلام ال CF1
+
+267
+00:24:08,460 --> 00:24:17,880
+بسهولة هي CF1 مظبوط؟ و هاد إيش CF2 يعني معناته0.8
+
+268
+00:24:17,880 --> 00:24:38,900
+زائد 0.6 مضروف في 1 نقص CF1 0.92
+
+269
+00:24:43,130 --> 00:24:48,590
+هذا درجة ثقتنا بإنه ال C هيحدث ان ال C is .. إيش
+
+270
+00:24:48,590 --> 00:24:57,190
+هو اللي بيقول هنا إيش ال rule بتقول C is Z عشان
+
+271
+00:24:57,190 --> 00:24:59,730
+كنت هيدر النتيجة لك ده عشان أختار ال rule واحدة
+
+272
+00:24:59,730 --> 00:25:02,530
+اللي هقولت يعني لأ مانديش أختار ال rule واحدة اللي
+
+273
+00:25:02,530 --> 00:25:07,970
+قولت في الأول .. في الأول كنا بيقول نختار ال rule
+
+274
+00:25:07,970 --> 00:25:13,030
+بس هنا we combine هنا في ال under uncertaintyعندما
+
+275
+00:25:13,030 --> 00:25:18,330
+يكون هناك فرصة غير متأكدة نجمع نتيجة رول واحد مع
+
+276
+00:25:18,330 --> 00:25:22,370
+نتيجة رول اتنين واضحة الفكرة الأساسية هنا هناك
+
+277
+00:25:22,370 --> 00:25:27,630
+نجمع ندمج هذا رول الأولى طلعت لي 80% و رول التاني
+
+278
+00:25:27,630 --> 00:25:32,250
+طلعت لي 60% أنا لن أأخذ واحد من التنتين لن أأخذ
+
+279
+00:25:32,250 --> 00:25:36,610
+واحد و أستثن الأخرى لأ حتى لو تلاتة سأخذهم كمان
+
+280
+00:25:36,610 --> 00:25:42,920
+سأخذهم و أدمجهم بالطريقة هذه بالأليهاأدمش طلع اما
+
+281
+00:25:42,920 --> 00:25:45,640
+انا دمشت تمانية واست تمانية في المية وستين في
+
+282
+00:25:45,640 --> 00:25:52,140
+المية ايش طلع معايا 92% زادت صح زادت زادت درجة
+
+283
+00:25:52,140 --> 00:25:55,600
+الموثوقية من هذا الاستنتاج هذا هو الاستنتاج
+
+284
+00:25:55,600 --> 00:25:59,380
+التنتين باستنتاجولي نفس الناتج التنتين اللي قلولي
+
+285
+00:25:59,380 --> 00:26:04,830
+ان C هتكون Zالمتغير الـ c هيكون ال value تبعه
+
+286
+00:26:04,830 --> 00:26:07,490
+الذات وهذا برضه بتقول اللي المتغير ال c هيكون ال
+
+287
+00:26:07,490 --> 00:26:10,990
+value تبعه الذات بس واحدة بتقول لي نسبة ثقتها من
+
+288
+00:26:10,990 --> 00:26:17,490
+كلامها 60% والتالية ثقتها من كلامها 80% طب انا اخد
+
+289
+00:26:17,490 --> 00:26:21,070
+مين هاخدهم الاتنين بس هدمجهم ويطلع معايا رقم جديد
+
+290
+00:26:21,070 --> 00:26:26,190
+الرقم معايا 92 أعلى من ال 80% و أعلى من ال 60% صح
+
+291
+00:26:26,190 --> 00:26:31,630
+تخيل الأمر كأنه اتنين قاعدينبشهدوا او بيأكدوا
+
+292
+00:26:31,630 --> 00:26:36,610
+حقيقة تمام انا بسأل فلان بقوله هل شفت المدرس اليوم
+
+293
+00:26:36,610 --> 00:26:40,170
+أجي على الجامعة؟ بقولي اه متأكد متأكد؟ بقولي اه
+
+294
+00:26:40,170 --> 00:26:43,430
+متأكد، جديش متأكد؟ تمانين في المية تمام؟ هذا في حد
+
+295
+00:26:43,430 --> 00:26:47,670
+ذاته كويس لما ييجي واحد تاني اسأله بقوله شفت
+
+296
+00:26:47,670 --> 00:26:54,870
+المدرس أجي على الجامعة؟ بقولي اه بقوله جديش؟متأكد
+
+297
+00:26:54,870 --> 00:27:00,790
+بيقولي 60% الان 60% صحيح أضعف من 80% ولكن كونها
+
+298
+00:27:00,790 --> 00:27:07,710
+جتنين اتنين شهادتين لنفس المعلومة هذا بيقوي درجة
+
+299
+00:27:07,710 --> 00:27:11,850
+ثقاتي أنا بإنه فعلا المعلومة صحيحة مظبوط ونفس
+
+300
+00:27:11,850 --> 00:27:16,270
+الأشياء لو كان بال negative هتلاقي إن الرقم اللي
+
+301
+00:27:16,270 --> 00:27:22,220
+طلع هيبدأ عالي بس بال negative okay يعني دمجحصل
+
+302
+00:27:22,220 --> 00:27:26,040
+دمج الشهادتين هذي شهادة و هذي شهادة حصل دمج
+
+303
+00:27:26,040 --> 00:27:33,080
+الشهادتين اه هيطلع اعلى من اي من هما و هيبقى في
+
+304
+00:27:33,080 --> 00:27:40,940
+الاشعار يعني لو المتناقضتين لو واحد بيقول 80%
+
+305
+00:27:40,940 --> 00:27:45,960
+بالمو جابه التاني بيقول 60% بالسالب يبقى الاتنين
+
+306
+00:27:45,960 --> 00:27:52,300
+بتضعفوا في بعض واحد بيشهد ضد الشهادته مناقضةشهادة
+
+307
+00:27:52,300 --> 00:27:57,560
+الآخر ال rule ال rules بنفضوا بعض يبقى بأخد ..
+
+308
+00:27:57,560 --> 00:28:02,420
+يبقى .. لما أنادي أحسن الاسم هذه اللي هي الحالة
+
+309
+00:28:02,420 --> 00:28:05,220
+الرسالة ده هو التلات حالات الحالة الأولى ان
+
+310
+00:28:05,220 --> 00:28:09,260
+الاتنين positive صح الحالة التالتة ان الاتنين
+
+311
+00:28:09,260 --> 00:28:12,800
+negative صح هذه واحدة منهم positive والتاني
+
+312
+00:28:12,800 --> 00:28:19,880
+negative صح في هذا الحالة هيطلع معايا قيمة أضعف من
+
+313
+00:28:19,880 --> 00:28:25,410
+أي منهميعني الموجب هتكون ضعفة والسلب هتكون ضعفة
+
+314
+00:28:25,410 --> 00:28:30,990
+صح؟ خلّيني أطلع هذا الكلام في الحالة هذه في الحالة
+
+315
+00:28:30,990 --> 00:28:35,330
+هذه اللي أمامنا في ال example هذا مافيه أن ال
+
+316
+00:28:35,330 --> 00:28:40,410
+certainty factor تبع ال evidence الأولاني موجب
+
+317
+00:28:40,410 --> 00:28:43,270
+واحد بينما ال certainty factor تبع ال evidence
+
+318
+00:28:43,270 --> 00:28:46,830
+التاني سلب واحد دخل الكلام هذا في المعادلة
+
+319
+00:28:46,830 --> 00:28:51,820
+هيتطلقلك ال rule هيتطلقلك ال certain factorالـ CF1
+
+320
+00:28:51,820 --> 00:28:58,680
+اللي هو الستنتاج بناء على رول رقم واحد موجب تمانية
+
+321
+00:28:58,680 --> 00:29:03,940
+موجب تمانية فم صح الاستنتاج بناء على رول رقم اتنين
+
+322
+00:29:03,940 --> 00:29:07,880
+هتنقص ستة في هذا الحالة مابقدرش اطبق نفس ال
+
+323
+00:29:07,880 --> 00:29:12,420
+formula لا هذه ولا التانية طبعا تبصي لازم اطبق ال
+
+324
+00:29:12,420 --> 00:29:18,200
+formula الأخرى اللي هي هذه اللي هي انه اجمعهم
+
+325
+00:29:18,200 --> 00:29:18,640
+الاتنين
+
+326
+00:29:23,310 --> 00:29:28,390
+على واحد نقص ال minimum ما بينهم ال minimum
+
+327
+00:29:28,390 --> 00:29:33,930
+absolute value بعد ما أشيل الإشارة يعني تمانية و
+
+328
+00:29:33,930 --> 00:29:38,430
+نقص ستة اللي
+
+329
+00:29:38,430 --> 00:29:42,210
+هو إيش؟ إيش ال minimum؟ شيلت أنا الإشارة تبعت
+
+330
+00:29:42,210 --> 00:29:48,150
+الستة ال minimum تبعهم نقص ستة ال 0.6 زي ما يعني
+
+331
+00:29:48,150 --> 00:29:57,740
+يعني واحد نقص 0.6 إيش بيسوي؟0.4 كلام هذا ايش فوق؟
+
+332
+00:29:57,740 --> 00:30:01,780
+مجموعهم مجموعهم طبعا واحد منهم هتكون اشارتها سالب
+
+333
+00:30:01,780 --> 00:30:11,140
+صح فتقلع 0.2 هذا نص هذا صح هذا 0.2 نص 0.4 ايش رأيك
+
+334
+00:30:11,140 --> 00:30:16,500
+في الرقم هذا الرقم هذا اقل من ال 8% وفي نفس الوجهة
+
+335
+00:30:16,500 --> 00:30:21,160
+اعلى من ال 0.6 صح
+
+336
+00:30:23,760 --> 00:30:30,720
+أجالي مانياشي ضغف
+
+337
+00:30:30,720 --> 00:30:36,260
+ضغف ضغف ضغف
+
+338
+00:30:36,260 --> 00:30:41,000
+ضغف ضغف ضغف
+
+339
+00:30:41,000 --> 00:30:41,860
+ضغف ضغف ضغف ضغف ضغف ضغف ضغف ضغف ضغف ضغف ضغف ضغف
+
+340
+00:30:41,860 --> 00:30:41,860
+ضغف ضغف ضغف ضغف ضغف ضغف ضغف ضغف ضغف ضغف ضغف ضغف
+
+341
+00:30:41,860 --> 00:30:41,860
+ضغف ضغف ضغف ضغف ضغف ضغف ضغف ضغف ضغف ضغف ضغف ضغف
+
+342
+00:30:41,860 --> 00:30:41,860
+ضغف ضغف ضغف ضغف ضغف ضغف ضغف ضغف ضغف ضغف ضغف ضغف
+
+343
+00:30:41,860 --> 00:30:41,860
+ضغف ضغف ضغف ضغف ضغف ضغف ضغف ضغف ضغف ضغف ضغف ضغف
+
+344
+00:30:41,860 --> 00:30:52,700
+ضغف ضغف ضغف ضغف
+
+345
+00:30:52,700 --> 00:30:56,430
+ضغوبعدين النادش تاخدوا مع السياف تلاتة اكتر من
+
+346
+00:30:56,430 --> 00:31:03,630
+evidence قلنا minimum و maximum اذا نفس ال rule
+
+347
+00:31:03,630 --> 00:31:08,270
+فيها اكتر من evidence اذا هم conjunction او
+
+348
+00:31:08,270 --> 00:31:16,110
+disjunction بتلاخد صح؟ احنا الأن أصبح عندنا هالية
+
+349
+00:31:16,110 --> 00:31:21,660
+لمعالجة ال rulesالقالية أو القاليات اللازمة
+
+350
+00:31:21,660 --> 00:31:28,820
+لمعالجة ال rules في حالة ال uncertainty أول قالية
+
+351
+00:31:28,820 --> 00:31:34,320
+كانت إن الاستنتاج تبع ال rule بخدوش زي ما هو
+
+352
+00:31:34,320 --> 00:31:37,560
+بالثقة أولا أولا أولا أحنا بنضيف certainty factor
+
+353
+00:31:37,560 --> 00:31:43,900
+لل rules فهذا أول حاجة استجدت عن كلامنا السابق أنه
+
+354
+00:31:43,900 --> 00:31:46,160
+صار ال rule لها certainty factor
+
+355
+00:31:49,070 --> 00:31:52,950
+هذا الكلام ترتب عليه انه انا الاستنتاج تبع رؤيس
+
+356
+00:31:52,950 --> 00:31:58,770
+الدولة دي تحققت استنتاج تبعها بدي اخد ال certainty
+
+357
+00:31:58,770 --> 00:32:01,470
+factor تبعها و اضربه في ال certainty factor تبع
+
+358
+00:32:01,470 --> 00:32:06,270
+مين ال evidence، مظبوط؟ عشان اخد ال certainty
+
+359
+00:32:06,270 --> 00:32:12,130
+factor تبع الاستنتاج هذا الموضوع المعناه ده،
+
+360
+00:32:12,130 --> 00:32:16,520
+مظبوط؟القضية التالتة اللي هي لما يكون في عندي
+
+361
+00:32:16,520 --> 00:32:21,860
+multiple evidence في ذاك ال rule الواحدة لاستخدام
+
+362
+00:32:21,860 --> 00:32:25,880
+ال minimum أو ال maximum القضية الرابعة النقطة
+
+363
+00:32:25,880 --> 00:32:29,000
+الرابعة اللي هي انه لما يكون في عندي more than one
+
+364
+00:32:29,000 --> 00:32:31,120
+rule تمام
+
+365
+00:32:32,910 --> 00:32:36,790
+more than one rule بتعطي نفس الاستنتاج ولكن ب
+
+366
+00:32:36,790 --> 00:32:41,430
+certain t factors متباينة نفس الاستنتاج اللي هو c
+
+367
+00:32:41,430 --> 00:32:45,710
+is z ولكن ب certain t factors مختلفة كيف بتعامل
+
+368
+00:32:45,710 --> 00:32:50,490
+معاهم بتعامل معاهم حسب إذا هم الإثنين موجبين أو
+
+369
+00:32:50,490 --> 00:32:54,990
+إثنين سالبين أو بختلفوا عن بعض تمام ال example
+
+370
+00:32:54,990 --> 00:33:02,120
+اللي بنطلع عليه الآن بشكل عملي أكتراللي هو Express
+
+371
+00:33:02,120 --> 00:33:08,340
+System بسيط جدا رول بيز فيه بس الستة rules هدولة
+
+372
+00:33:08,340 --> 00:33:13,320
+أطلع عليهم
+
+373
+00:33:13,320 --> 00:33:19,600
+هو
+
+374
+00:33:19,600 --> 00:33:23,320
+about a forecast لتنبؤ أو لتوقع حالة إتجار Express
+
+375
+00:33:23,320 --> 00:33:29,390
+System is required to predict whetherwhether it
+
+376
+00:33:29,390 --> 00:33:33,370
+will rain tomorrow or in other words to establish
+
+377
+00:33:33,370 --> 00:33:36,890
+certain factors for the not valid object tomorrow
+
+378
+00:33:36,890 --> 00:33:41,970
+هذا الان tomorrow ايش سماه object تذكره linguistic
+
+379
+00:33:41,970 --> 00:33:46,950
+variables و linguistic objects تمام فهو عبارة عن
+
+380
+00:33:46,950 --> 00:33:52,610
+متغير متغيره ايه هو القيمة تبعته هتكون اما rain او
+
+381
+00:33:52,610 --> 00:33:58,310
+dry او ايشRain or Dry بالظبط انه يا اما هتمطر يا
+
+382
+00:33:58,310 --> 00:34:02,670
+اما مش هتمطر بس الان في اندي certainty factor ال
+
+383
+00:34:02,670 --> 00:34:09,510
+certainty factors تبعت الرموز المختلفة الان ايش
+
+384
+00:34:09,510 --> 00:34:12,490
+بتوقع ان ال system عشان يشتغل بعد ما نعطيه الرموز
+
+385
+00:34:12,490 --> 00:34:18,470
+هذا يسوي بده يشتغل ب forward chaining او backward
+
+386
+00:34:18,470 --> 00:34:18,950
+chaining
+
+387
+00:34:22,130 --> 00:34:26,010
+هيبدأ .. إذا .. إذا هو بدي .. ال system بدي افترض
+
+388
+00:34:26,010 --> 00:34:30,790
+أنه بكرا dry معناه ذلك إيش؟ بدي يبدأ يسألني عن ال
+
+389
+00:34:30,790 --> 00:34:34,810
+إيش؟ المعطيات اللي بدي .. اه وين فيه rule بتقوللي
+
+390
+00:34:34,810 --> 00:34:38,110
+dry هيجي يقوللي هل today is dry؟ هيسألني السؤال
+
+391
+00:34:38,110 --> 00:34:42,010
+هذا إذا بدي أمشي forward forward sharing هيمسك ال
+
+392
+00:34:42,010 --> 00:34:47,550
+rules وشوف إيش في عنده معطيات لسه مافيش معطياتفإيش
+
+393
+00:34:47,550 --> 00:34:51,090
+بيسوي؟ حيسأل ال user هيقول له إيش بتتوقع؟ إيش
+
+394
+00:34:51,090 --> 00:34:56,830
+اليوم الحالة؟ تمام؟ فهيكون عن طريق ال dialogue
+
+395
+00:34:56,830 --> 00:35:00,910
+طبعا what is the weather today؟ فال user بيقول له
+
+396
+00:35:00,910 --> 00:35:07,570
+rain تمام؟ فبنان على ذلك ال rules اللي عندي are
+
+397
+00:35:07,570 --> 00:35:10,970
+that today is rain, today is dry, today is rain,
+
+398
+00:35:11,270 --> 00:35:14,750
+today is rain, today is dry, today is dry أول
+
+399
+00:35:14,750 --> 00:35:24,750
+واحدة من ال rulesبالطابق اللي هي هادي صح مظبوط و
+
+400
+00:35:24,750 --> 00:35:33,270
+في عندنا هادي today is rain و today is rain يبقى
+
+401
+00:35:33,270 --> 00:35:40,070
+هو بناء على رول رقم واحد الآن بده
+
+402
+00:35:40,070 --> 00:35:44,110
+يحسب ايش بده
+
+403
+00:35:44,110 --> 00:35:50,610
+يحسبهذا ال hypothesis جدّيش احتماليته ان tomorrow
+
+404
+00:35:50,610 --> 00:36:05,710
+is rain جدّيش احتماليتها كيف
+
+405
+00:36:05,710 --> 00:36:10,830
+حسب؟ ده رامة في الواحد بس مافيش كلمة توضعية ده في
+
+406
+00:36:10,830 --> 00:36:17,700
+الواحدعشان كان واحد بيحكيلي انه بكرا مثلا حلقين
+
+407
+00:36:17,700 --> 00:36:27,360
+تشتت ماجيبش سيرة جادة في البيت صحيح صحيح صحيح صحيح
+
+408
+00:36:27,360 --> 00:36:35,460
+الان الان
+
+409
+00:36:35,460 --> 00:36:39,220
+هو لما ياخدها على انها rain لما ياخدها على انها
+
+410
+00:36:39,220 --> 00:36:43,350
+rain تفترض انه rain 100%فأشتغل على هذا الأساس على
+
+411
+00:36:43,350 --> 00:36:47,730
+الأساس أنها مية في المية و ضربة في واحد تمام ما هو
+
+412
+00:36:47,730 --> 00:36:51,210
+أصلا يا إما في رين يا إما مافيش رين و ليلا احنا
+
+413
+00:36:51,210 --> 00:36:56,190
+بنحكي عن اليوم يا إما كانت ماطر يا إما ماكانش ماطر
+
+414
+00:36:56,190 --> 00:37:06,690
+مابنحكيش عن إشي يعني هذا متوقع okay
+
+415
+00:37:06,690 --> 00:37:17,070
+الآنالان هناك رولز تانية تسأل عن المطر والمستوى
+
+416
+00:37:17,070 --> 00:37:23,410
+المطر يعني الان هو بناء على هذا ال rule لحالها حسب
+
+417
+00:37:23,410 --> 00:37:28,010
+هذا ال rule لكن ايضا هناك رولز تانية تسأل عن مطر
+
+418
+00:37:28,010 --> 00:37:35,870
+اليوم والمطر اليوم مخلص حسنا
+
+419
+00:37:35,870 --> 00:37:41,160
+فالان هو بعد ما خلصبعد ما خلصت دورة ال cycle
+
+420
+00:37:41,160 --> 00:37:50,140
+الأولى حسب اليوم اليوم اليوم اليوم اليوم اليوم
+
+421
+00:37:50,140 --> 00:37:50,400
+اليوم اليوم اليوم اليوم اليوم اليوم اليوم اليوم
+
+422
+00:37:50,400 --> 00:37:50,420
+اليوم اليوم اليوم اليوم اليوم اليوم اليوم اليوم
+
+423
+00:37:50,420 --> 00:37:50,700
+اليوم اليوم اليوم اليوم اليوم اليوم اليوم اليوم
+
+424
+00:37:50,700 --> 00:37:51,440
+اليوم اليوم اليوم اليوم اليوم اليوم اليوم اليوم
+
+425
+00:37:51,440 --> 00:38:01,400
+اليوم اليوم اليوم اليوم
+
+426
+00:38:01,400 --> 00:38:04,620
+اليوم اليوم اليوم اليوم اليوم اليوم اليوم اليوم
+
+427
+00:38:04,620 --> 00:38:07,060
+اليوم اليوم اليوم اليوم اليوم اليوم اليوم اليوم
+
+428
+00:38:07,060 --> 00:38:07,060
+اليوم اليوم اليوم اليوم اليوم اليوم اليوم اليوم
+
+429
+00:38:07,060 --> 00:38:07,060
+اليوم اليوم اليوم اليوم اليوم اليوم اليوم اليوم
+
+430
+00:38:07,060 --> 00:38:07,060
+اليوم اليوم اليوم اليوم اليوم اليوم اليوم اليوم
+
+431
+00:38:07,060 --> 00:38:07,060
+اليوم اليوم اليوم اليوم اليوم اليوم اليوم اليوم
+
+432
+00:38:07,060 --> 00:38:07,060
+اليوم اليوم اليوم اليوم اليوم اليوم اليوم اليوم
+
+433
+00:38:07,060 --> 00:38:11,100
+اليوم اليوم اليوم اليوم اليوم اليمظبوط يعني هذا
+
+434
+00:38:11,100 --> 00:38:14,860
+القول عشان ينفذها هذا already معلوم لكن هذا لسه مش
+
+435
+00:38:14,860 --> 00:38:20,420
+معلوم فبده يسأل انا عن هذا الكلام فلما في الدورة
+
+436
+00:38:20,420 --> 00:38:24,500
+التانية سألت طبعا هنا ال 50% هذا واضح اضرب الواحد
+
+437
+00:38:24,500 --> 00:38:28,300
+في ال 50% اللي هي certainty factor تبع ال role
+
+438
+00:38:28,300 --> 00:38:34,380
+نفسها لما سأل بعد هيك عن what
+
+439
+00:38:34,380 --> 00:38:40,470
+is the rainfall today وقالله okayالان ال law هذا
+
+440
+00:38:40,470 --> 00:38:47,730
+ال law هذا عشان rule رقم تلاتة بتطلب هل كان رين و
+
+441
+00:38:47,730 --> 00:38:52,170
+جديش كان ال rainfall سألوا الان to what degree do
+
+442
+00:38:52,170 --> 00:38:56,110
+you believe ال rainfall is law الان كلمة ال law ما
+
+443
+00:38:56,110 --> 00:38:59,530
+هي برضه برضه كمان بتنا ..الها ..الها certainty
+
+444
+00:38:59,530 --> 00:39:04,290
+factor تمام فسألوا قالوا zero point eight الان
+
+445
+00:39:04,290 --> 00:39:12,560
+صارت rule رقم تلاتة rule رقم تلاتةtoday's rain is
+
+446
+00:39:12,560 --> 00:39:17,160
+a certain factor هذا هو الوضع الأولاني وهذا هو
+
+447
+00:39:17,160 --> 00:39:27,960
+الوضع التاني rainfall is low جرداش 0.8 بما أن ال
+
+448
+00:39:27,960 --> 00:39:31,860
+compound condition هذا conjunction فلازم يأخذ ال
+
+449
+00:39:31,860 --> 00:39:34,840
+minimum ال minimum ما بينهم اللي هو 0.8 و يضربها
+
+450
+00:39:34,840 --> 00:39:39,950
+في مين ال 0.6 تبع التطور و نطلع 48لأنه استنتج
+
+451
+00:39:39,950 --> 00:39:48,950
+حاليا صار عنده استنتاج انه انه ايش بناء
+
+452
+00:39:48,950 --> 00:39:51,950
+على ال rule الأولى ايش كان الاستنتاج ان rain خمسين
+
+453
+00:39:51,950 --> 00:39:56,250
+في المية بناء على ال rule هذا كان tomorrow is rain
+
+454
+00:39:56,250 --> 00:40:02,550
+خمسين في المية هي rain خمسين في المية والان ال
+
+455
+00:40:02,550 --> 00:40:06,410
+rule التاني ال rule رقم تلاتة بتستنتج الاستنتاج
+
+456
+00:40:06,410 --> 00:40:07,430
+اخر ويقوله
+
+457
+00:40:14,200 --> 00:40:20,320
+هذا الكلام كيف نتعامل معاه هل .. هذا ايش هذا ..
+
+458
+00:40:20,320 --> 00:40:24,760
+هذا الآن ال .. ال .. ال conclusion بتعطي .. ال
+
+459
+00:40:24,760 --> 00:40:29,040
+system بيعطي two facts بيقول لي ان tomorrow رح
+
+460
+00:40:29,040 --> 00:40:33,910
+يكون رينأو two predictions سيقول لي انه سيكون رين
+
+461
+00:40:33,910 --> 00:40:36,870
+و في نفس الوقت سيقول لي انه سيكون dry بس بالنسبة
+
+462
+00:40:36,870 --> 00:40:45,490
+المتفاوتة هل الآن نعمل combination ندمج؟
+
+463
+00:40:45,490 --> 00:40:52,390
+هاي tomorrow و هاي tomorrow لأ
+
+464
+00:40:52,390 --> 00:40:58,190
+مابندمجش احنا ندمج لما تكون نفس ال fact او نفس ال
+
+465
+00:40:58,190 --> 00:41:00,720
+conclusion بالنسبة المتفاوتةبس هنا two conclusions
+
+466
+00:41:00,720 --> 00:41:06,180
+طب مش هتساوي في هذا الحالة باخدها عادة ممكن ال
+
+467
+00:41:06,180 --> 00:41:12,060
+system يعطيلي two recommendations يقوللي هتكون
+
+468
+00:41:12,060 --> 00:41:19,880
+مطرة و برضه يقوللي هتكون هذا جافة اه ممكن ممكن لسه
+
+469
+00:41:19,880 --> 00:41:26,060
+متفاوتة إذا الأمر المعطيات ما بتساهم على أنه نحسم
+
+470
+00:41:26,550 --> 00:41:32,510
+فبيظل الأمر عايم بين الهدف جدّام لو في الدورة اللي
+
+471
+00:41:32,510 --> 00:41:35,450
+بعد في ال cycle اللي بعد ال system سأل سؤال
+
+472
+00:41:35,450 --> 00:41:40,410
+وعطيناه إجابة و الإجابة هذه هتكون لها دور في ترجيح
+
+473
+00:41:40,410 --> 00:41:44,590
+كفة أحد التوقعات
+
+474
+00:41:44,590 --> 00:41:51,090
+على الآخربعد ذلك السيستم سأل what is the
+
+475
+00:41:51,090 --> 00:41:53,990
+temperature؟ يعني أنه الآن أنت فاكر فيها forward
+
+476
+00:41:53,990 --> 00:41:57,930
+shading السيستم قاعد يلف ويدور على أيش فيه rules
+
+477
+00:41:57,930 --> 00:42:01,710
+عنده ومين منهم fires هذه كانت الأولى والتالتة
+
+478
+00:42:01,710 --> 00:42:04,810
+already fired لأنه يريد أن يشوف هل في المزيد كان
+
+479
+00:42:04,810 --> 00:42:08,590
+fired ولا لأ بس المزيد هذا بيعتمد على معبيات إذا
+
+480
+00:42:08,590 --> 00:42:12,490
+وقفنا على rule و ال rule هذه فيها شق ماعناش
+
+481
+00:42:12,490 --> 00:42:18,560
+المعلومة اللي بعتمد علينا نسأل ال userwhat is the
+
+482
+00:42:18,560 --> 00:42:21,900
+temperature today سأل عن ال temperature cold قال
+
+483
+00:42:21,900 --> 00:42:24,000
+له to what degree do you believe that the
+
+484
+00:42:24,000 --> 00:42:29,380
+temperature is cold قال له تسعة في المية الان هذا
+
+485
+00:42:29,380 --> 00:42:33,880
+كان اصلا السؤال اللي اجى لانه كان مقفل في الساكين
+
+486
+00:42:33,880 --> 00:42:36,780
+اللي على الرغم من الرقم 4 فسأل عن ال temperature
+
+487
+00:42:36,780 --> 00:42:42,260
+وسأل عن جداش درجة المثوقية انها cold فالان في عند
+
+488
+00:42:42,260 --> 00:42:48,430
+هنا two ولا تلاتة evidencesEvidence الأولى يعني
+
+489
+00:42:48,430 --> 00:42:54,210
+Today's
+
+490
+00:42:54,210 --> 00:42:57,810
+rain هذا عندنا وعندنا الإيجاب تبعته وعندنا ال
+
+491
+00:42:57,810 --> 00:43:00,970
+certainty تبعته هذا rainfall اللي هو عندنا وعندنا
+
+492
+00:43:00,970 --> 00:43:05,810
+ال certainty تبعته هذا اللي استجدت وصار عندنا وصار
+
+493
+00:43:05,810 --> 00:43:10,450
+ال certainty تبعته قداش كده كانت 0.9 فالأن برضه
+
+494
+00:43:10,450 --> 00:43:16,650
+لأنهم end فبناخد ال minimum ال minimum بين الواحدو
+
+495
+00:43:16,650 --> 00:43:23,190
+التسعة و أيضا ايش اللي قبل مش كان تسعة التمانية صح
+
+496
+00:43:23,190 --> 00:43:27,730
+التمانية تبعد اللي هو rainfall واحد و التمانية و
+
+497
+00:43:27,730 --> 00:43:30,730
+التسعة ايش ال minimum اللي هي التمانية بتنضرر في
+
+498
+00:43:30,730 --> 00:43:34,870
+سبعة بلاش ستة و خمسين الان ستة و خمسين tomorrow is
+
+499
+00:43:34,870 --> 00:43:41,850
+dry صح tomorrow is dry صارت ستة و خمسين و كانت
+
+500
+00:43:41,850 --> 00:43:43,630
+تمانية و اربعين و كانت تمانية و اربعين
+
+501
+00:43:48,940 --> 00:43:53,440
+اللي هو compound بالظبط بتعمل combination و لا مش
+
+502
+00:43:53,440 --> 00:43:59,840
+شادة لأ لسه لسه تمام
+
+503
+00:43:59,840 --> 00:44:05,360
+ايه الان صار في عندي ان rule تلاتة و rule اربع
+
+504
+00:44:05,360 --> 00:44:09,980
+rule تلاتة اللي قالتلي انه dry تمانية و اربعين هذا
+
+505
+00:44:09,980 --> 00:44:15,920
+الكلام اجا من rule و هذا الكلام انه rain اجا من
+
+506
+00:44:16,510 --> 00:44:20,890
+الان استجد علينا رول ستة تجعلني اقول ان اليوم هو
+
+507
+00:44:20,890 --> 00:44:30,570
+إدراي بس بالنسبة .. صح فهنا دول الان ال
+
+508
+00:44:30,570 --> 00:44:35,370
+conclusion هي نفسها بس ب two different what؟ ب two
+
+509
+00:44:35,370 --> 00:44:39,210
+different certainty values صح؟ الان انا لازم اعمل
+
+510
+00:44:39,210 --> 00:44:45,290
+compilation هنا ال certainty factor الإجمالي
+
+511
+00:44:46,030 --> 00:44:49,070
+من ال role تلاتة من ال certainty factor تبقى ال
+
+512
+00:44:49,070 --> 00:44:50,550
+role تلاتة من ال certainty factor تبقى ال role
+
+513
+00:44:50,550 --> 00:44:55,090
+أربعة ايش هم بيستخدموا الآن اي formula لأنهم
+
+514
+00:44:55,090 --> 00:44:58,690
+الاتنين موجبين فبستخدموا ال formula اللي كنا نحكي
+
+515
+00:44:58,690 --> 00:45:04,050
+عنها اللي هي الأول زاد التاني مضروبا في واحد نقص
+
+516
+00:45:04,050 --> 00:45:11,690
+الأول فطلع 77 شايف كيف عززوا بعض ال twocertainties
+
+517
+00:45:11,690 --> 00:45:17,350
+او uncertainties عززوا بعض فزادت الاحتمالية انه
+
+518
+00:45:17,350 --> 00:45:31,830
+صار عندي 0.7% هذا ال combined صرت انا اكتر
+
+519
+00:45:31,830 --> 00:45:39,100
+للاعتقاد انه تكون dryالان ال system بيستمر في
+
+520
+00:45:39,100 --> 00:45:44,100
+القالية هذه بيستمر في القالية هذه الى ان مايظلش
+
+521
+00:45:44,100 --> 00:45:50,120
+فيه rules اللي يمكن مطابقتها ايش يعني ان هم هدول
+
+522
+00:45:50,120 --> 00:45:55,780
+ال 6 rules خليني ارجع لهم الان هدول ال 6 rules
+
+523
+00:45:55,780 --> 00:46:00,060
+خلاص استنفذ ال .. ايش المعطيات اللي او استنفذت ال
+
+524
+00:46:00,060 --> 00:46:04,240
+conditions بتاعتهم ماضلش في اشي اللي يمكن مطابقته
+
+525
+00:46:05,090 --> 00:46:11,650
+كوني قولتلي ان اليوم ريان يبقى مافيش مجال انه هادى
+
+526
+00:46:11,650 --> 00:46:18,890
+.. خلّي بالك ان اليوم مطر اجت من وين اجت .. اجت
+
+527
+00:46:18,890 --> 00:46:22,750
+نتيجة .. نتيجة الاستنتاج هذا تبع .. تبع الرقم
+
+528
+00:46:22,750 --> 00:46:31,390
+تلاتة مش انا اللي قلتله ان tomorrow مش انا اللي
+
+529
+00:46:31,390 --> 00:46:36,410
+قلتله مش انا اللي قلتلههو ماتيش الاستنتاجات رول
+
+530
+00:46:36,410 --> 00:46:39,510
+ستة هذه اللي اتولدت فيها او رول اربع ناسف انا
+
+531
+00:46:39,510 --> 00:46:43,970
+اخبطت رول اربع رول اربع ده بقول كيف اجت اليوم جمال
+
+532
+00:46:43,970 --> 00:46:48,150
+جمال اليوم is rain و rainfall is low و temperature
+
+533
+00:46:48,150 --> 00:46:51,710
+is cold هدولة كلهم اجوا من ليش من الموقعات اللي
+
+534
+00:46:51,710 --> 00:46:58,130
+اعطيته اليوم فبنقول اذا كان لازال في rules أخرى
+
+535
+00:46:58,130 --> 00:47:04,390
+يمكنمطابقتها وممكن تقديتها ب effects بيستمر غير
+
+536
+00:47:04,390 --> 00:47:10,330
+كبير جف وبيعطيني هذه الأرقام منها اليه؟ اليه اللي
+
+537
+00:47:10,330 --> 00:47:15,090
+مافيه بوابها بس هو قال لي اليوم مدهش هادى خلاص
+
+538
+00:47:15,090 --> 00:47:18,130
+هادى مدهش هادى اه و بعدين كمان temperature
+
+539
+00:47:18,130 --> 00:47:21,290
+temperature اللي انا قولتله ان ال temperature is
+
+540
+00:47:21,290 --> 00:47:25,950
+low فخلاص هادى كيف ده تصير true رقم خمسة
+
+541
+00:47:28,580 --> 00:47:32,240
+الكلام هنا عن tomorrow tomorrow هو اللي dry انا
+
+542
+00:47:32,240 --> 00:47:36,480
+حسنت ال rule رقم خمسة لأني طلعت بره الموضوع من
+
+543
+00:47:36,480 --> 00:47:41,860
+النوم ما قلتله today is rain صح
+
+544
+00:47:41,860 --> 00:47:49,780
+اصبح مافي مجال ان هذا تتحقق لان today is dry وستة
+
+545
+00:47:49,780 --> 00:47:52,600
+كذا مش هتتحقق نعم طلعت بره
+
+546
+00:47:58,890 --> 00:48:05,390
+هذا باختصار شديد يعني اللي هو فحوة ال certainty
+
+547
+00:48:05,390 --> 00:48:09,310
+factor theory
+
+548
+00:48:09,310 --> 00:48:15,270
+وقالية التطبيقه في ال rule based express system
+
+549
+00:48:15,270 --> 00:48:21,110
+الحاضرة الجاية بنحكي في ال Bayesian rule
+
+550
+00:48:21,110 --> 00:48:25,070
+وكيف يمكن توظيفها في ال rule based express system
+
diff --git a/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/KAA7H6-ZP-I_postprocess.srt b/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/KAA7H6-ZP-I_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..39b1bd891072289e4c5ac3918397487c9910868f
--- /dev/null
+++ b/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/KAA7H6-ZP-I_postprocess.srt
@@ -0,0 +1,1620 @@
+1
+00:00:20,650 --> 00:00:23,110
+بسم الله الرحمن الرحيم احنا اليوم ان شاء الله بدنا
+
+2
+00:00:23,110 --> 00:00:26,450
+نكمل الموضوع اللي فتحناه قبل هيكه في المحاضرات
+
+3
+00:00:26,450 --> 00:00:32,610
+الماضية اللي هو ال artificial neural networks ال
+
+4
+00:00:32,610 --> 00:00:35,670
+supervised learning باستخدام ال artificial neural
+
+5
+00:00:35,670 --> 00:00:42,570
+networks كنا في المحاضرة الماضية حكينا عن اللي هو
+
+6
+00:00:42,570 --> 00:00:48,290
+ال Perceptron وشوفنا قالية العمل تبعتهو آلية
+
+7
+00:00:48,290 --> 00:00:53,090
+التعلم اللي هي مقصودة بالتعديل الأوزاني و بعدين
+
+8
+00:00:53,090 --> 00:00:57,270
+كمان ايضا اطلعنا على ال multi-layered networks ال
+
+9
+00:00:57,270 --> 00:01:00,270
+multi-layered networks اللي هي عبارة عن شبكة من ال
+
+10
+00:01:00,270 --> 00:01:05,850
+perceptrons الشبكة هذه مهيكلة على أساس layers و ال
+
+11
+00:01:05,850 --> 00:01:08,890
+layers كل layer فيها مجموعة من ال perceptrons
+
+12
+00:01:08,890 --> 00:01:13,090
+بتغذي المجموعة اللي بعدها أو ال layer اللي بعدها
+
+13
+00:01:14,080 --> 00:01:18,840
+وشوفنا آلية الآن التعلم في ال multilayer networks
+
+14
+00:01:18,840 --> 00:01:23,080
+صح آلية التعلم المفصولة بها مرة أخرى اللي هي آلية
+
+15
+00:01:23,080 --> 00:01:27,420
+تعديل الأوزان وشوفنا كيف بتختلف آلية تعديل الأوزان
+
+16
+00:01:27,420 --> 00:01:36,000
+في ال output يرعنها في ال hidden layer صح الآن
+
+17
+00:01:36,000 --> 00:01:40,290
+احنا بدنانلقي نظرة أخيرة على ال multilayer
+
+18
+00:01:40,290 --> 00:01:44,510
+networks بعدين بنحكي في جزئية صغيرة اللي هي ال
+
+19
+00:01:44,510 --> 00:01:48,610
+accelerating اللي هي النقطة هذه ماضح النقطة هذه
+
+20
+00:01:48,610 --> 00:01:53,170
+اللي هي accelerated learning المقصود بيها تسريع
+
+21
+00:01:53,170 --> 00:01:56,710
+عملية التعلم عملية التعلم احنا فاهمين انها بتحصل
+
+22
+00:01:56,710 --> 00:02:04,390
+على شكل ايش iterations iterations مظبوط وسمينا كل
+
+23
+00:02:04,390 --> 00:02:08,630
+مجموعة من ال iterations سمينها epo صحالـ Epoch هو
+
+24
+00:02:08,630 --> 00:02:14,970
+دفعة أو short من ال iterations عملية التسريع هو
+
+25
+00:02:14,970 --> 00:02:21,870
+تقليل عدد ال iterations بدل من أن ال network تأخذ
+
+26
+00:02:21,870 --> 00:02:29,940
+400 دورة 400 iterations قبل أن تستقر الأوزانلما
+
+27
+00:02:29,940 --> 00:02:33,020
+بنقول احنا بدنا نسرع لقليلة التعلم، معناه ذلك
+
+28
+00:02:33,020 --> 00:02:36,240
+الأربعمية هدولة بدنا نختصرهم أو بنجللهم إلى تلت
+
+29
+00:02:36,240 --> 00:02:42,100
+مية، إلى متين، إلى مية ربما، بدون أن ننطقش من دقة
+
+30
+00:02:42,100 --> 00:02:48,290
+التعلمهذه النقطة اللي هي المقصود بها اللي هو
+
+31
+00:02:48,290 --> 00:02:52,730
+accelerated learning او ممكن نقول accelerating ال
+
+32
+00:02:52,730 --> 00:02:55,570
+learning يعني تسريع التعلم في ال multi neural
+
+33
+00:02:55,570 --> 00:02:59,390
+networks بعد ما نخلص النقطة هذه ان شاء الله بنتطلع
+
+34
+00:02:59,390 --> 00:03:03,250
+على ال hub field network و ال BAM اللي هي
+
+35
+00:03:03,250 --> 00:03:07,010
+bidirectional associative memories هدولة نوعين من
+
+36
+00:03:07,010 --> 00:03:13,420
+ال artificial neural networksاللي بينطور تحت إطار
+
+37
+00:03:13,420 --> 00:03:18,200
+اللي هو supervised learning طيب، إيش قلنا بدنا
+
+38
+00:03:18,200 --> 00:03:20,640
+نبدأ في الأول بإيش؟ بإننا نلقي نظرة أخيرة على ال
+
+39
+00:03:20,640 --> 00:03:23,920
+multilayer neural networks اللي كنا حكينا فيها من
+
+40
+00:03:23,920 --> 00:03:28,400
+قبل بدنا نتقل على طريقة ال slide اللي فيها ال
+
+41
+00:03:28,400 --> 00:03:34,040
+example اللي تبع تتذكروا تبع إيش؟ تبع تدريب ال
+
+42
+00:03:34,040 --> 00:03:41,100
+network علىاللي هو ال XOR ال XOR gate او ال XOR
+
+43
+00:03:41,100 --> 00:03:44,900
+function ذاكرين
+
+44
+00:03:44,900 --> 00:03:49,700
+هذا المثال اما كنا بنحكي انه هاي ال neural network
+
+45
+00:03:49,700 --> 00:03:54,920
+في عندنا التلاتة nodes هدولة node رقم تلاتة و رقم
+
+46
+00:03:54,920 --> 00:03:58,020
+اربعة هدولة تابعين لأنهي layer ال hidden layer
+
+47
+00:03:58,020 --> 00:04:03,460
+مظبوط ال hidden layer صح و ال output layer ايش
+
+48
+00:04:03,460 --> 00:04:07,660
+فيهافيها node واحدة اللي هي node number five صح
+
+49
+00:04:07,660 --> 00:04:13,200
+لأن ال input بيدخل ب X1 و X2 على node number one و
+
+50
+00:04:13,200 --> 00:04:16,700
+node number two ملاحظين هدول ال two nodes شكلهم
+
+51
+00:04:16,700 --> 00:04:22,780
+مربع لتمييزهم عن من عن ال nodes الأخرى مميزين بإيش
+
+52
+00:04:22,780 --> 00:04:26,300
+إيش الفرق ما بينهم إن هدول ما بيعملوش أي
+
+53
+00:04:27,210 --> 00:04:31,330
+calculations مابعملوش أي computation صح مجرد اللي
+
+54
+00:04:31,330 --> 00:04:35,890
+بيدخل عليهم بتوزع علي مين علي بعدهم okay يبقى احنا
+
+55
+00:04:35,890 --> 00:04:39,730
+عمليا في المثال هذا يوم ما بدنا نيجي نحسب و نعد
+
+56
+00:04:39,730 --> 00:04:42,990
+الأوزان و نعد الأوزان بس تلاتة و أربعة و خمسة
+
+57
+00:04:42,990 --> 00:04:47,470
+مظبوط بنبدأ من مين من الخمسة في الأول بالظبط لإن
+
+58
+00:04:47,470 --> 00:04:52,080
+الخمسة هي اللي عندها desired outputو هي اللى بتقدر
+
+59
+00:04:52,080 --> 00:04:55,460
+تعرف ال error او تحسب ال error و بعدها بتطلع ال
+
+60
+00:04:55,460 --> 00:04:59,420
+error بتعدل أوزانها و بعدها بترحل ال error
+
+61
+00:04:59,420 --> 00:05:02,820
+gradient الى مين الى تلاتة و أربعة ال error
+
+62
+00:05:02,820 --> 00:05:07,900
+gradient اللى ذكره هو small delta بترحل الى تلاتة
+
+63
+00:05:07,900 --> 00:05:10,740
+و الى أربعة عشان كل واحدة منهم تلاتة و أربعة تحسب
+
+64
+00:05:10,740 --> 00:05:15,230
+ال error تبعها ال error gradient تبعها يعنيعشان
+
+65
+00:05:15,230 --> 00:05:18,730
+تعدّل أوزانها بناء عليه هذه الكلام هي total طبعا
+
+66
+00:05:18,730 --> 00:05:22,710
+هنا في ال slide هذه بيعقيلك ال initial values تبع
+
+67
+00:05:22,710 --> 00:05:30,390
+ال ايش الأوزان
+
+68
+00:05:30,390 --> 00:05:34,230
+ال threshold
+
+69
+00:05:34,230 --> 00:05:41,980
+that theta صح؟ مصبوط؟بعد ذلك هنا بيبدأ الحسبة أول
+
+70
+00:05:41,980 --> 00:05:46,260
+شيء بيحسب ال Y3 ال output اللي بدي يطلع من Y3
+
+71
+00:05:46,260 --> 00:05:53,100
+مظبوط بس احنا قلنا أول حاجة بدي تم تعديل الأوزان
+
+72
+00:05:53,100 --> 00:05:59,840
+فيها على Y5 طب ليش بدأنا في Y3 و Y4؟ لأن وصل ال Y5
+
+73
+00:06:01,600 --> 00:06:05,000
+بتعرف كيف تحسب ال output تبعها لازم يجيها input من
+
+74
+00:06:05,000 --> 00:06:09,120
+وين بتجيها ال input من Y3 و Y4 يبقى لازم أحسب Y3 و
+
+75
+00:06:09,120 --> 00:06:13,800
+Y4 ليش بدهم يطلعوا عشان نسلموا ل Y5 عشان Y5 تحسب
+
+76
+00:06:13,800 --> 00:06:16,580
+ال output تبعها تبعها دلوقت لإن شوف إيش فيه error
+
+77
+00:06:16,580 --> 00:06:22,180
+و اترحل تاني يعني احنا forward propagation
+
+78
+00:06:22,180 --> 00:06:26,140
+of data و backward propagation of error
+
+79
+00:06:26,140 --> 00:06:31,070
+information صح؟ okayهي الآن بعد ما طلعت ويتلت و ..
+
+80
+00:06:31,070 --> 00:06:34,050
+من حسب ويتلت و .. طبعا ويتلت ال activation
+
+81
+00:06:34,050 --> 00:06:37,870
+function استخدمت اللي هي ال sigmoid ال sigmoid
+
+82
+00:06:37,870 --> 00:06:41,270
+طبعا يوم ما يكون في عندك مثلة أو امتحان أو كده ال
+
+83
+00:06:41,270 --> 00:06:44,830
+formula هتبدو مواطية لك انت بس مجرد ايش بتاخد
+
+84
+00:06:44,830 --> 00:06:48,110
+الأرقام و بتطلع ال output ال output لأن ال sigmoid
+
+85
+00:06:48,110 --> 00:06:51,330
+بتطلع continuous values يعني ايش يعني أرقام عشرية
+
+86
+00:06:51,330 --> 00:06:58,750
+مش binary زي مين زي ال stepو ليش؟ بال pulse
+
+87
+00:06:58,750 --> 00:07:04,010
+function صح؟ okay فالان هذه ال continuous values
+
+88
+00:07:04,010 --> 00:07:07,870
+او ال real values او ال float values بتدخش على مين
+
+89
+00:07:07,870 --> 00:07:12,350
+على Y5 تنضرب في الأوزن تبعها و تتاخذ مع ال
+
+90
+00:07:12,350 --> 00:07:16,750
+threshold عشان تطلع ال output تبع Y5 من هنا الأن
+
+91
+00:07:16,750 --> 00:07:20,610
+نبدأ نشوف ليش ال error ال error اللي انا بنحسب هو
+
+92
+00:07:20,610 --> 00:07:24,610
+عبارة عن ببساطة ال difference ما بين ال desired ال
+
+93
+00:07:24,610 --> 00:07:32,080
+desired لما كانلما يكون عندي انا ال X واحد X واحد
+
+94
+00:07:32,080 --> 00:07:36,240
+انا بقشر هنا X واحد و X اتنين الاتنين ال input ال
+
+95
+00:07:36,240 --> 00:07:41,340
+value تبعهم one one one لازم ال X core function
+
+96
+00:07:41,340 --> 00:07:42,120
+تعطيني ايش
+
+97
+00:07:50,560 --> 00:07:54,460
+Y5 يفترض أن يكون Zero بس ماهو اللي بيطلع معنا هنا
+
+98
+00:07:54,460 --> 00:07:56,580
+في ال calculation هذا يفترض أن يكون Zero بس ماهو
+
+99
+00:07:56,580 --> 00:07:56,920
+اللي بيطلع معنا هنا في ال calculation هذا يفترض أن
+
+100
+00:07:56,920 --> 00:07:56,960
+يكون Zero بس ماهو اللي بيطلع معنا هنا في ال
+
+101
+00:07:56,960 --> 00:08:03,540
+calculation هذا يفترض أن يكون Zero بس
+
+102
+00:08:03,540 --> 00:08:05,000
+ماهو اللي بيطلع معنا هنا في ال calculation هذا
+
+103
+00:08:05,000 --> 00:08:06,320
+يفترض أن يكون Zero بس ماهو اللي بيطلع معنا هنا في
+
+104
+00:08:07,180 --> 00:08:09,700
+الـ small delta تبعه هاي الخمسة اللي هي ايش اسمها
+
+105
+00:08:09,700 --> 00:08:13,220
+ال error gradient شوف أنا وين بقشر هنا ال error
+
+106
+00:08:13,220 --> 00:08:18,200
+gradient اذا ذكروها هذا المصطلح ان هو ال small
+
+107
+00:08:18,200 --> 00:08:23,070
+deltaال aero gradient هذا لما بنحسب بعد هيكة على
+
+108
+00:08:23,070 --> 00:08:27,630
+أساسه تتعدى للأوزان الأوزان تبعون ال inputs اللي
+
+109
+00:08:27,630 --> 00:08:33,890
+داخلة على Y خمسة صح؟ من هم هدول الأوزان W تلاتة
+
+110
+00:08:33,890 --> 00:08:38,190
+خمسة و W أربعة خمسة ليش أسميهم هيكة لإن واحد منهم
+
+111
+00:08:38,190 --> 00:08:42,670
+جاي من تلاتة إلى خمسة والتاني جاي من أربعة إلى
+
+112
+00:08:42,670 --> 00:08:47,470
+خمسة او الاصح ان احنا نقول واحد منهم هو وزن ال
+
+113
+00:08:47,470 --> 00:08:51,610
+input اللي جايمن ثلاثة إلى خمسة والتاني هو وزن ال
+
+114
+00:08:51,610 --> 00:08:56,910
+input اللي جاي من أربعة إلى خمسة صح؟ طبعا فأول اشي
+
+115
+00:08:56,910 --> 00:09:00,370
+عشان نعدل الأوزن نحسب ال delta تبع الوزن مقدار
+
+116
+00:09:00,370 --> 00:09:08,390
+التغير بعدين بنضيف ذلك على ال current أو ال weight
+
+117
+00:09:08,390 --> 00:09:13,250
+الوزن الحالي عشان يطلع معانا وزن جديد نفس الاشي
+
+118
+00:09:13,250 --> 00:09:18,000
+بنعمل لمين؟الـ Theta ، الـ Threshold لاحظوا أن
+
+119
+00:09:18,000 --> 00:09:20,900
+عملي التعليل الأوزان ببساطة شديدة يعني الـ Delta
+
+120
+00:09:20,900 --> 00:09:22,880
+يبقى عبارة عن الـ Alpha اللي هو ال learning rate
+
+121
+00:09:22,880 --> 00:09:28,920
+مضروب في ال .. قيمة ال input اللي بيخش عبر هذا
+
+122
+00:09:28,920 --> 00:09:33,740
+الوزن مضروب في ال Delta small Delta اللي هي ال
+
+123
+00:09:33,740 --> 00:09:38,840
+Delta 5 فهي Delta 5 موجودة في التلت حسبات
+
+124
+00:09:40,110 --> 00:09:44,130
+طيب هذا الكلام ايش خلصنا ده هذا الكلام بس لحساب
+
+125
+00:09:44,130 --> 00:09:48,210
+الأوزان تبعد من ال input اللي داخلها على مين على
+
+126
+00:09:48,210 --> 00:09:52,450
+y5 لازم نعيد نفس الاشي لل inputs اللي داخلها على
+
+127
+00:09:52,450 --> 00:10:01,630
+y3 و y4 صح؟ okay هذا الكلام نفس القاليم بس طبعا
+
+128
+00:10:01,630 --> 00:10:05,270
+لازم في الأول كل واحدة من y3 و y5 تحسب ال error
+
+129
+00:10:05,270 --> 00:10:09,520
+gradient تبعها اللي هو ال small delta تبعتهاوبعدين
+
+130
+00:10:09,520 --> 00:10:15,220
+عليه small delta تدخل
+
+131
+00:10:15,220 --> 00:10:19,040
+في حساب الأوزان اللي رايح على تلاتة وبعدين small
+
+132
+00:10:19,040 --> 00:10:21,860
+delta تبعد أربعة تدخل في حساب الأوزان اللي رايح
+
+133
+00:10:21,860 --> 00:10:29,800
+على أربعة انا الآن بدل ما اني طبعا هنا بعد هيك
+
+134
+00:10:29,800 --> 00:10:35,020
+الأوزان اللي هو w واحد على تلاتة واحد على أربعة
+
+135
+00:10:35,020 --> 00:10:37,840
+اتنين على تلاتة اتنين على اربعة تلاتة على خمسة
+
+136
+00:10:37,840 --> 00:10:44,500
+تلاتة على اربعةOkay بدل أنا الآن نمر بهذا الحساب
+
+137
+00:10:44,500 --> 00:10:48,900
+خطوة خطوة لأ أنا بدي أجيب و أقولك الآن اعتبر انت
+
+138
+00:10:48,900 --> 00:10:53,340
+بدك تكمل المثال هذا ال iteration اللي بعت هذ ال
+
+139
+00:10:53,340 --> 00:10:56,880
+iteration الأولى ولا لأ لإن هذ ال iteration انبنت
+
+140
+00:10:56,880 --> 00:11:01,760
+على ال initial ال initialish values تبع الأوزان
+
+141
+00:11:01,760 --> 00:11:07,610
+مصبوط انت الآن خد هذاو خد ال input اللي بعده مين
+
+142
+00:11:07,610 --> 00:11:09,750
+ال input اللي بعده اذا كان ال input الأولاني كان
+
+143
+00:11:09,750 --> 00:11:17,430
+one one خد zero one x1 ب zero و x2 ب one و عيد
+
+144
+00:11:17,430 --> 00:11:25,890
+الكرة من جديد بالأوزان اللي هذه اللي نتجت من نهاية
+
+145
+00:11:25,890 --> 00:11:28,390
+ال iteration الأولى انت الآن بدك تحسب ال iteration
+
+146
+00:11:28,390 --> 00:11:33,310
+التانية بتقدر تعمل هذا الكلام ولا لا بتقدر اذا
+
+147
+00:11:33,310 --> 00:11:37,740
+أعطيناك homework ان شاء الله بتقدرلأ فخلاص هي الان
+
+148
+00:11:37,740 --> 00:11:42,260
+homework هي الان homework مطموعة منك أيش تسوي تعيد
+
+149
+00:11:42,260 --> 00:11:47,140
+الكلام ده كله لل iteration number two عشان تطلع
+
+150
+00:11:47,140 --> 00:11:52,140
+أيش في الآخر الأوزان يعني في الآخر بدك تطلع صفحة
+
+151
+00:11:52,140 --> 00:11:59,710
+زي هيك فيها أوزان جديدةاللي بدها تجف عندها اللي هو
+
+152
+00:11:59,710 --> 00:12:02,110
+ال iteration التاني في نهاية ال iteration التاني
+
+153
+00:12:02,110 --> 00:12:05,870
+ايش هتكون قيمة الأوزان الجديدة و ال thresholds
+
+154
+00:12:05,870 --> 00:12:11,430
+جديدة okay طيب هيك بنكون احنا القيل النظر الأخير
+
+155
+00:12:11,430 --> 00:12:16,470
+على عملية ال back propagation learning واضح ليش
+
+156
+00:12:16,470 --> 00:12:20,150
+اسمها back propagation لأن احنا بنحمل ال error
+
+157
+00:12:20,150 --> 00:12:25,100
+لوراعلى ال layers من ال outward على ال hidden ال
+
+158
+00:12:25,100 --> 00:12:28,600
+hidden طبعا ممكن تبقى layer واحدة او اكتر نين ممكن
+
+159
+00:12:28,600 --> 00:12:33,880
+two hidden layers ماشي
+
+160
+00:12:33,880 --> 00:12:37,240
+هاد الان احنا بدنا نحكي في ال acceleration كيف
+
+161
+00:12:37,240 --> 00:12:44,540
+يمكن تسريع التسريع ال learning هذا ال curve لو
+
+162
+00:12:44,540 --> 00:12:50,300
+لاحظت عليه ايش بيمثل علاقة ايش بايش هنا epoقول
+
+163
+00:12:50,300 --> 00:12:53,940
+iterations لأن ال book الواحد هي مجموعة iterations
+
+164
+00:12:53,940 --> 00:12:57,300
+فانا هنا من zero عشان خمسين مية مية خمسين ميتين
+
+165
+00:12:57,300 --> 00:13:02,580
+اقصد بيها ايش ميتين iterations مية خمسين
+
+166
+00:13:02,580 --> 00:13:07,980
+iterations كل ما بزيد عدد ال iterations يفترض ان
+
+167
+00:13:07,980 --> 00:13:15,020
+ال error ايش بيصير فيه بيجل بيتنقص احنا الآن ال
+
+168
+00:13:15,020 --> 00:13:18,490
+errorأحيانا ال network بتبقى ال output layer
+
+169
+00:13:18,490 --> 00:13:23,890
+تبعتها فيها ال node واحدة فهو error واحد مصبوط
+
+170
+00:13:23,890 --> 00:13:28,410
+أحيانا بيبقى ال layer الأخيرة بيبقى فيها عد تش
+
+171
+00:13:29,090 --> 00:13:32,310
+notes وبالتالي ال error في عندي error للأولى error
+
+172
+00:13:32,310 --> 00:13:35,630
+للتانية عدة errors مصموم فإحنا لو جينا ببساطة
+
+173
+00:13:35,630 --> 00:13:39,870
+شديدة ربعنا ال errors هذه وجمعنا مربعاتهم بيطلع
+
+174
+00:13:39,870 --> 00:13:43,870
+عني هنا some square error some square error يعني
+
+175
+00:13:43,870 --> 00:13:52,170
+مقصود بمجموع مربعات ال errors تابعة من تابعة
+
+176
+00:13:52,170 --> 00:13:58,630
+ال notesهناك أيضا تدخل في الحسبة هالي ال errors
+
+177
+00:13:58,630 --> 00:14:02,670
+تبع ال hidden layers ال hidden nodes برضه ممكن
+
+178
+00:14:02,670 --> 00:14:05,790
+نيجي نقول خلينا نجمع كل ال nodes اللي في ال
+
+179
+00:14:05,790 --> 00:14:10,410
+network سواء output nodes ولا hidden nodes و نجمع
+
+180
+00:14:10,410 --> 00:14:14,910
+ال errors تبعه منهم طبعا نعبيها في الأول و نجمع
+
+181
+00:14:14,910 --> 00:14:19,540
+بيطلع معايا some square errorsome square error هذا
+
+182
+00:14:19,540 --> 00:14:24,480
+يصلح أن يكون مؤشر على إيش على أداء الشبكة أداء ال
+
+183
+00:14:24,480 --> 00:14:28,460
+network هل تعلمت أو لا صح لأن كل ما عليه ال error
+
+184
+00:14:28,460 --> 00:14:32,940
+هذا معناته هي لسه لسه
+
+185
+00:14:32,940 --> 00:14:37,360
+بتخطط لسه بتخطط صح طب احنا في الأول ليش بنربّل
+
+186
+00:14:37,360 --> 00:14:41,040
+نعمل تربيع ال error ليش ما ناخده زي ما هو قولنا
+
+187
+00:14:41,040 --> 00:14:44,340
+هذا لأن بعض ال errors بتبقى بالموجب وبعض بالسالب
+
+188
+00:14:44,340 --> 00:14:47,560
+لو جمعناهم هم ممكن يصفروا بعضهم
+
+189
+00:14:50,980 --> 00:14:54,800
+مربعهم على انه مؤشر صح لكن لما نبقى ربع ال errors
+
+190
+00:14:54,800 --> 00:14:59,200
+الموجب والسالب بيصير موجب و لا لأ المربعات بيصير
+
+191
+00:14:59,200 --> 00:15:03,900
+موجب فنقدر ننظر اليش الي مجموع المربعات على انه
+
+192
+00:15:03,900 --> 00:15:08,660
+مؤشر على ايش مؤشر
+
+193
+00:15:08,660 --> 00:15:15,620
+على ايش مؤشر على التعلم جد جيشي تعلمتفهذا الخط
+
+194
+00:15:15,620 --> 00:15:20,460
+الأزرق أزرق بطالة أزرق أزرق لما بينزل هيكا معناته
+
+195
+00:15:20,460 --> 00:15:28,320
+إيش مع استمرار عملية التعلم جاعد إيش ال error بجل
+
+196
+00:15:28,320 --> 00:15:33,740
+صح مع استمرار تشغيل ال iterations ال error جاعد
+
+197
+00:15:33,740 --> 00:15:38,940
+بجل فإحنا الآن لما بقول accelerating معناته بدنا
+
+198
+00:15:38,940 --> 00:15:45,170
+ينزل للصفر الصفرهو بعدد ايش اقل من ال iterations
+
+199
+00:15:45,170 --> 00:15:49,670
+فبنتقل
+
+200
+00:15:49,670 --> 00:15:55,410
+الان الى هذا ال slide
+
+201
+00:15:55,410 --> 00:15:59,830
+هناOkay هي بداية اللي هو اللي حاكي عن ال
+
+202
+00:15:59,830 --> 00:16:04,770
+accelerated learning اعتبرها accelerating learning
+
+203
+00:16:04,770 --> 00:16:10,190
+يعني ان هو احنا نسرع عملية التعلم ففي عندنا عدة
+
+204
+00:16:10,190 --> 00:16:14,350
+techniques او عدة خطوات او إجراءات ممكن تنعمل
+
+205
+00:16:14,350 --> 00:16:17,650
+تغيير بسيطة تغييرات بسيطة على تصميم ال neural
+
+206
+00:16:17,650 --> 00:16:21,410
+network عساس انه تخلي عملية التعلم أسرع شوية واحدة
+
+207
+00:16:21,410 --> 00:16:27,410
+منها اللي هي انه ال outputيعني ال .. ال .. ال
+
+208
+00:16:27,410 --> 00:16:30,010
+sigmoid function اللي على .. اللي هي ال activation
+
+209
+00:16:30,010 --> 00:16:36,670
+function يعاد صياغتها بهذا الصينةبهذا السبب اللي
+
+210
+00:16:36,670 --> 00:16:40,790
+هو انه احنا يكون في عندي two constants a و b ال
+
+211
+00:16:40,790 --> 00:16:45,730
+two constants a و b هدولة ينحسب ال ال y اللي هو ال
+
+212
+00:16:45,730 --> 00:16:49,910
+output تبع ال perceptron او النود الواحدة بهذه
+
+213
+00:16:49,910 --> 00:16:52,890
+القلية بدل ما بهذه ال equation بدل ال equation
+
+214
+00:16:52,890 --> 00:16:55,650
+الأساسية هذه ال equation هي عبارة عن ال equation
+
+215
+00:16:55,650 --> 00:16:59,890
+تمثل sigmoid functionمش إش جديد بس صياغة أخرى
+
+216
+00:16:59,890 --> 00:17:05,370
+إليها الصياغة هذه بتساعد على تسريع اختصار وجد يعني
+
+217
+00:17:05,370 --> 00:17:11,460
+تغيير الأوزان بكميات أكبر وصولا إلي إيشوصولا الى
+
+218
+00:17:11,460 --> 00:17:17,880
+اوزان بتعطي error اقل فهذه الطريقة الأولى اللي هي
+
+219
+00:17:17,880 --> 00:17:22,860
+استخدام ال hyperbolic tangent function او صيغة ال
+
+220
+00:17:22,860 --> 00:17:26,540
+hyperbolic tangent تبع ال sigmoid function بدل ال
+
+221
+00:17:26,540 --> 00:17:30,460
+direct sigmoid هذا الكلام مش هوصفه ليش لأنه بده
+
+222
+00:17:30,460 --> 00:17:32,980
+mathematical foundation حل ال mathematical
+
+223
+00:17:32,980 --> 00:17:39,640
+foundation ل .. ل .. ليش؟
+
+224
+00:17:41,620 --> 00:17:46,340
+لـ course يكون في الجزء النظري أكتر فإحنا الآن
+
+225
+00:17:46,340 --> 00:17:49,560
+بدنا ننتقل على هذا هو الطريقة الأولى هذا الطريقة
+
+226
+00:17:49,560 --> 00:17:53,880
+الأولى لتسريع عملية التعلم طريقة تانية اللي هو
+
+227
+00:17:53,880 --> 00:17:57,300
+إحنا نستخدم حاجة اسمها momentum term اتطلع على
+
+228
+00:17:57,300 --> 00:18:01,860
+المعادلة هذه اتطلع على الشق هذا هل الشق هذا شفناه
+
+229
+00:18:01,860 --> 00:18:05,600
+قبل هيك أول شيء ايش اللي على اليسار اللي يساوي
+
+230
+00:18:05,600 --> 00:18:12,400
+اللي هو ال delta W اللي هو إيشفرق الوزن بالعادة
+
+231
+00:18:12,400 --> 00:18:16,380
+احنا بنعرف ان فرق الوزن هو في المحصلة هيك بس مجرد
+
+232
+00:18:16,380 --> 00:18:21,280
+ال alpha مضروبة في ال input مضروبة في small delta
+
+233
+00:18:21,280 --> 00:18:25,700
+للأ اذكركم في هذا الكلام هيتوا ارجع هنا ورا شوية
+
+234
+00:18:25,700 --> 00:18:30,980
+ارجع هنا ورا شوية هيتوا هي delta صح عبارة عن ايش
+
+235
+00:18:30,980 --> 00:18:35,450
+alpha مضروبة في XX اللي هي ال inputمضروف ليس في
+
+236
+00:18:35,450 --> 00:18:38,410
+دلتا دلتا اللي هي error gradient تبع ال node نفسها
+
+237
+00:18:38,410 --> 00:18:43,530
+اللي نحسب لها تلاتة او زمن الداخلة عليها من واحد و
+
+238
+00:18:43,530 --> 00:18:53,830
+من اتنين مبدئيا للي مش حافظ تعديل الوزن delta w هي
+
+239
+00:18:53,830 --> 00:18:56,690
+عبارة عن ببساطة learning rate
+
+240
+00:18:59,110 --> 00:19:02,870
+مضروب في ال input اللى داخل على ال node من هذا
+
+241
+00:19:02,870 --> 00:19:07,810
+الوزن مضروب في ال gradient طيب ايش الاستجاد
+
+242
+00:19:07,810 --> 00:19:11,710
+الاستجاد هذا ال band هذا او هذا ال term هذا ال
+
+243
+00:19:11,710 --> 00:19:14,790
+term اللى هو ال momentum term momentum يعني الدفع
+
+244
+00:19:14,790 --> 00:19:18,450
+بيعطي الدفع لعملية التعلمة هو ببساطة شديدة عبارة
+
+245
+00:19:18,450 --> 00:19:22,970
+عن beta هي عبارة عن constant صغير ما بين ال zero
+
+246
+00:19:22,970 --> 00:19:28,630
+والواحد مضروب في ايشمضروف في ايش؟ في الـ delta
+
+247
+00:19:28,630 --> 00:19:33,190
+point يعني بدنا الآن ال network تتذكر ال delta
+
+248
+00:19:33,190 --> 00:19:39,050
+السابق احنا نحسب ال delta تبع P و بنقول انه بدنا
+
+249
+00:19:39,050 --> 00:19:44,210
+ال delta تبع P نقص واحد يعني ايش؟ ال delta السابق
+
+250
+00:19:44,210 --> 00:19:50,310
+مش الوزن السابق مش W لأ delta W بدنا ناخده هذا
+
+251
+00:19:51,510 --> 00:19:57,390
+نحتفظ فيه للدورة اللاحقة عشان نضربه في مين في ال
+
+252
+00:19:57,390 --> 00:20:04,590
+beta هذا الكلام بشكل دفع لمين لعملية التعلم وهذا
+
+253
+00:20:04,590 --> 00:20:11,070
+ال beta قيمة تتراوح من zero لواحد عادة تبتد قريبة
+
+254
+00:20:11,070 --> 00:20:17,690
+من الواحد قريبة من الواحد يعني 0.95 مثلا فهذا اللي
+
+255
+00:20:17,690 --> 00:20:18,150
+هو الآن
+
+256
+00:20:27,380 --> 00:20:32,280
+two methods او two measures او two steps او two
+
+257
+00:20:32,280 --> 00:20:41,980
+techniques ليش for accelerating أول
+
+258
+00:20:41,980 --> 00:20:42,920
+واحد ايش كانت؟
+
+259
+00:21:01,740 --> 00:21:06,060
+الثاني استخدام ايش
+
+260
+00:21:06,060 --> 00:21:11,540
+momentum constant term لأ ال constant هو جزء من ال
+
+261
+00:21:11,540 --> 00:21:15,100
+term هذا هو كله عبارة عن ال momentum term تتكوّل
+
+262
+00:21:15,100 --> 00:21:20,260
+من حاجتين مضروبات في بعض اللي هم ال momentum
+
+263
+00:21:20,260 --> 00:21:26,540
+constant اللي هي beta مضربة في ال W تبعت ال
+
+264
+00:21:26,540 --> 00:21:34,100
+iteration السابقهذا ال term بينجمع على ال term
+
+265
+00:21:34,100 --> 00:21:40,240
+الأصلي تبع تعديل الأوزان اللي هو ال alpha مضروبة
+
+266
+00:21:40,240 --> 00:21:48,820
+في ال input مضروبة في ال error gradient error
+
+267
+00:21:48,820 --> 00:21:54,780
+gradient اللي هي small delta تمام؟
+
+268
+00:21:54,780 --> 00:21:57,800
+إيش
+
+269
+00:21:57,800 --> 00:22:02,890
+غير إيك؟ هدولا طريقتين اللي قاله إيشأو أسلوبين لـ
+
+270
+00:22:02,890 --> 00:22:10,710
+Accelerating Learning غير هيكة هذا المثال نفس
+
+271
+00:22:10,710 --> 00:22:20,270
+المثال اللي قبل هيكة بوريها كيف ال
+
+272
+00:22:20,270 --> 00:22:27,770
+learning rate هنا ثابت ماتغيرش ثابت و ال error
+
+273
+00:22:27,770 --> 00:22:37,800
+بينزل ال error بينزلصار بدل ما أخدت بدل
+
+274
+00:22:37,800 --> 00:22:44,280
+ما تاخد 200 iteration عشان يقترب ال error من ال
+
+275
+00:22:44,280 --> 00:22:52,340
+zero أخدت جداش 126
+
+276
+00:22:52,340 --> 00:22:57,120
+epo او iteration مش مشكلة المهم القصد أنه انضغط
+
+277
+00:22:57,120 --> 00:23:03,340
+الأمر من 200 إلى 126هذا باستخدام ال momentum term
+
+278
+00:23:03,340 --> 00:23:11,320
+لما أضيف ال momentum term على تصميم formula تعديل
+
+279
+00:23:11,320 --> 00:23:18,920
+الوزن صار اختزل او جل الوجد الى 126 ابوك بدل 200
+
+280
+00:23:18,920 --> 00:23:25,340
+ابوك الآن اضافة إلى هذول ال two techniques رقم
+
+281
+00:23:25,340 --> 00:23:27,360
+تلاتة اللى هو ال heuristics
+
+282
+00:23:33,520 --> 00:23:37,660
+plastics هذو لا فيها any tools rule بتقول إنه إذا
+
+283
+00:23:37,660 --> 00:23:43,780
+كان أنا قاعد باجمع اللي هو إيش ال sum of square
+
+284
+00:23:43,780 --> 00:23:46,940
+errors إيش هو ال sum of square errors بتذكرها لو
+
+285
+00:23:46,940 --> 00:23:51,040
+لسه كنا نحكي اللي هو بجمع ال errors تبعد كل ال
+
+286
+00:23:51,040 --> 00:23:55,900
+nodes و بربعها أولا بخدها بربعها بعدين بجمع
+
+287
+00:23:55,900 --> 00:24:01,900
+مربعاتها إذا من epo ل epo ال sum of square errors
+
+288
+00:24:01,900 --> 00:24:12,120
+هذاsome of square errors باستمرار
+
+289
+00:24:12,120 --> 00:24:20,060
+ال some هذا من
+
+290
+00:24:20,060 --> 00:24:26,520
+واحد للي بعده اما في ازدياد يعني في الاول كان ال
+
+291
+00:24:26,520 --> 00:24:30,780
+some نقول مثلا تلاتة بعدين صار اربع بعدين صار خمسة
+
+292
+00:24:30,780 --> 00:24:31,280
+بعدين ستة
+
+293
+00:24:35,780 --> 00:24:45,980
+بيزيد او الاكس انه في النزول يعني ال sum تبع هذا
+
+294
+00:24:45,980 --> 00:24:49,400
+ال epoch اقل من اللي جابله و اللي بعد اقل و اللي
+
+295
+00:24:49,400 --> 00:24:53,220
+بعد اقل جاء بتنقص هذا الكلام مش معناته معناته لما
+
+296
+00:24:53,220 --> 00:24:58,800
+انا بقى اخد الفرق من تلاتة نقص اربعة بيطلع نقص
+
+297
+00:24:58,800 --> 00:25:02,220
+واحد اربعة نقص خمسة بيطلع نقص واحددائما .. دائما
+
+298
+00:25:02,220 --> 00:25:09,020
+.. دائما الفرق .. دائما الفرق اشارته بالسلب وهنا
+
+299
+00:25:09,020 --> 00:25:13,620
+نفس الاشي برضه سواء كان هو صعودا او هبوطا لما انا
+
+300
+00:25:13,620 --> 00:25:17,500
+اجي اقول مثلا هذه عشرة و لبعدها تسعة و لبعدها
+
+301
+00:25:17,500 --> 00:25:21,800
+تمانية عشر اناقص تسعة واحد تسعة اناقص تمانية واحد
+
+302
+00:25:21,800 --> 00:25:29,120
+فالفرق دائما اشارته موجبة هنا دائما اشارته السلبة
+
+303
+00:25:31,690 --> 00:25:37,390
+إذا دايما هيك .. إذا دايما .. إذا ال change of the
+
+304
+00:25:37,390 --> 00:25:42,510
+sum of square .. change .. ال change .. التغير
+
+305
+00:25:42,510 --> 00:25:45,510
+يعني هنا من عشر إلى تسعة و تسعة إذا دايما هذا ال
+
+306
+00:25:45,510 --> 00:25:49,130
+change .. كيف أنا بحسب ال change؟ باخد الفرق إذا
+
+307
+00:25:49,130 --> 00:25:54,310
+دايما هذا الفرق بحافظ على نفس ال signنفس الإشارة
+
+308
+00:25:54,310 --> 00:25:58,190
+اما دايما موجبة او دايما سالبة يبقى انا في عندي
+
+309
+00:25:58,190 --> 00:26:03,250
+اضطراد انا في عندي حاجة اسمها ال .. ال .. ال .. ال
+
+310
+00:26:03,250 --> 00:26:05,830
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+311
+00:26:05,830 --> 00:26:06,070
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+312
+00:26:06,070 --> 00:26:06,150
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+313
+00:26:06,150 --> 00:26:06,370
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+314
+00:26:06,370 --> 00:26:06,690
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+315
+00:26:06,690 --> 00:26:07,830
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+316
+00:26:07,830 --> 00:26:07,950
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+317
+00:26:07,950 --> 00:26:11,010
+ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+318
+00:26:11,010 --> 00:26:15,430
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+319
+00:26:15,430 --> 00:26:20,430
+ال ..
+
+320
+00:26:20,430 --> 00:26:26,230
+ال .. الفي ال square في sum of square errors يبقى
+
+321
+00:26:26,230 --> 00:26:33,570
+أنا المفروض أسرع أزيد ال alpha فإذا كان اختصر هذا
+
+322
+00:26:33,570 --> 00:26:39,770
+ال linguistic كالتالي إذا كانت ال sign of sum of
+
+323
+00:26:39,770 --> 00:26:42,570
+square errors ولا حد الاختصار
+
+324
+00:26:51,530 --> 00:26:54,230
+و بعدها كلمة stable ايش هان stable؟ يعني مافيش
+
+325
+00:26:54,230 --> 00:26:59,310
+فيها تذبذب مش مرة زائد و مرة ناقص يعني مش انه مرة
+
+326
+00:26:59,310 --> 00:27:05,390
+تلاقي هيك هنا الفرق هذا ناقص هذا سالب سالب بعد هيك
+
+327
+00:27:05,390 --> 00:27:09,710
+الفرق صار موجب مظبوط؟ هنا مافيش فرق هنا صار سالب
+
+328
+00:27:09,710 --> 00:27:13,110
+سالب سالب هنا موجب هذا تذبذب في ايش؟ في ال sign
+
+329
+00:27:13,110 --> 00:27:21,150
+إذا كان ال sign is stable فإيش بسوي increase alpha
+
+330
+00:27:22,950 --> 00:27:25,930
+ألفة اللي هي learning rate وشوفتها في واحدة من
+
+331
+00:27:25,930 --> 00:27:30,210
+الأمثلة كانت 0.1 increase يعني بخليها 0.2 مثلا
+
+332
+00:27:30,210 --> 00:27:36,270
+بخليها 0.3 او بقيت و بقول بدي اضربها دايما بيزيدها
+
+333
+00:27:36,270 --> 00:27:43,910
+ب 5% يعني 0.1 بدي أثير 0.105 يعني بخلي بمخصر أن
+
+334
+00:27:43,910 --> 00:27:51,070
+ألفة تساوي ألفة ضرب واحد هذا معناته بيزيدها ب 5%
+
+335
+00:27:52,090 --> 00:27:57,250
+ممكن أقول لأ ده زي ده 15% ممكن أقول ده زي ده 25%
+
+336
+00:27:57,250 --> 00:28:02,350
+المهم أنا بقى أثبت ليه نسبة زيادة امتى بتزيد امتى
+
+337
+00:28:02,350 --> 00:28:05,290
+بقى طابت ده الكلام لما قاللي انه ال sign ثابت
+
+338
+00:28:05,290 --> 00:28:12,790
+العكس من ذلك إذا ال algebraic sign of ال change ال
+
+339
+00:28:12,790 --> 00:28:16,950
+change اللي هو يعني مقصود يتغير في ال alternates
+
+340
+00:28:16,950 --> 00:28:21,190
+session alternates يتذبذب مرة أخر مرة موجة مرة
+
+341
+00:28:21,190 --> 00:28:25,760
+سالباللي هو معناه ذلك .. معناه ذلك في عندي ال ..
+
+342
+00:28:25,760 --> 00:28:31,620
+ال network مرة بتقترب .. مرة بتقترب و بجل ال error
+
+343
+00:28:31,620 --> 00:28:36,780
+و مرة بتبعد فجيها غيرت الأوزان بشكل كبير صار يطلع
+
+344
+00:28:36,780 --> 00:28:41,570
+معاها error و بعدين كانت مقتربة، بس إيش؟التغيير
+
+345
+00:28:41,570 --> 00:28:45,550
+اللي حصل كان تغيير كبير في الأوزان خلها تفشج عن ..
+
+346
+00:28:45,550 --> 00:28:50,290
+زي ما هم بيقولها تخطي الصواب و صارت الاش تبعد و
+
+347
+00:28:50,290 --> 00:28:54,430
+بعدين صارت تترد تاني بس لما ردت مارجعتش على الصواب
+
+348
+00:28:54,430 --> 00:28:57,890
+فشجت عنه ب .. فصار .. فإيش فيه مشكلة؟ المشكلة أنها
+
+349
+00:28:57,890 --> 00:29:01,450
+بتخطي خطوات واسعة فانا بضيق الخطوات هذه كيف بضيق
+
+350
+00:29:01,450 --> 00:29:08,770
+الخطوات؟ بنزل الاش ال alpha ال learning rate فإذا
+
+351
+00:29:08,770 --> 00:29:19,460
+كان ال signخلاص فأقول S إذا هي مش stable sign
+
+352
+00:29:19,460 --> 00:29:25,700
+of SSE alternates
+
+353
+00:29:25,700 --> 00:29:29,960
+معناه
+
+354
+00:29:29,960 --> 00:29:34,880
+ذلك decrease الألف
+
+355
+00:29:34,880 --> 00:29:39,830
+decrease الألف برضه يكون عندي كمانبتقدر تتخيل يعني
+
+356
+00:29:39,830 --> 00:29:48,910
+هنا هو مثلا ال decrease
+
+357
+00:29:48,910 --> 00:29:56,070
+بأنه بضربها ب 70% ب 7 من 10 يعني بنزلها 30% تمام و
+
+358
+00:29:56,070 --> 00:30:03,790
+ال increase بضربها في 1 و 5 من 100 واضح تمام فهنا
+
+359
+00:30:03,790 --> 00:30:10,570
+بوريلك كيف انه هايالـ Epochs ماشية و في ده ال دي
+
+360
+00:30:10,570 --> 00:30:18,250
+ال learning rate قاعد بتساعد نتيجة تطبيق إيش؟ هذي
+
+361
+00:30:18,250 --> 00:30:23,250
+تمام؟ قاعد بيحسب لجأ أنه ال error ال software
+
+362
+00:30:23,250 --> 00:30:26,810
+errors قاعد في النازل صح في النازل يعني إشارته
+
+363
+00:30:26,810 --> 00:30:32,170
+دايما موجبة مظبوط؟ بقى أطرح السابق و بقى أطرح منه
+
+364
+00:30:32,170 --> 00:30:37,960
+اللاحق و طلعت موجب فهو بسبب أنه هذا موجبالتغير
+
+365
+00:30:37,960 --> 00:30:44,780
+موجب اه التغير موجب فهو عمار بيرفع في ليش في اللي
+
+366
+00:30:44,780 --> 00:30:49,000
+عند حد معين جلب
+
+367
+00:30:49,000 --> 00:30:53,540
+ال ال
+
+368
+00:30:53,540 --> 00:30:59,840
+alphaبدأت تنزل و نزولها لأن وضعها في 0.7 النزول
+
+369
+00:30:59,840 --> 00:31:04,000
+أسرع أو أحد من الصعود صعود تدريج بسيط 5% كل مرة
+
+370
+00:31:04,000 --> 00:31:11,240
+انما هنا 30% كل مرة فبدأت تنزل نزلة جامدة مين هي
+
+371
+00:31:11,240 --> 00:31:14,980
+اللي هو ال learning rate نزل نزل جامدة مع النزلة
+
+372
+00:31:14,980 --> 00:31:20,640
+هذه بدأ يقترب من ايش من بوريلك فعلية هذا الأسلوب
+
+373
+00:31:20,640 --> 00:31:22,440
+في الاقتراب من
+
+374
+00:31:25,600 --> 00:31:33,420
+من ال error المخفض بوقت أقل 100 epoch بدلا من 126
+
+375
+00:31:33,420 --> 00:31:39,920
+epoch هذا
+
+376
+00:31:39,920 --> 00:31:45,280
+الأن استخدم ال momentum مع برضه هذه الهيروستيك
+
+377
+00:31:45,280 --> 00:31:48,960
+اقبال adaptive ايش يعني adaptive يعني لما نقول
+
+378
+00:31:48,960 --> 00:31:53,100
+adapter ايش يعني adapter يعني محولadaptive يعني
+
+379
+00:31:53,100 --> 00:31:58,260
+أنه يتحول ويغير من تلقاء نفسه ماهو اللي بتغير من
+
+380
+00:31:58,260 --> 00:32:02,240
+تلقاء نفسه ال learning rate لوحده بناء على
+
+381
+00:32:02,240 --> 00:32:07,980
+استشعاره لل sign تبعت من ال sum of square arrows
+
+382
+00:32:07,980 --> 00:32:12,180
+هو نفسه من تلقاء نفسها ال network بتغير في ال
+
+383
+00:32:12,180 --> 00:32:15,460
+learning rate تبعها عشان ذلك اسم هذا الكلام
+
+384
+00:32:15,460 --> 00:32:19,680
+adaptive learning فلما اندمج ال two techniques ال
+
+385
+00:32:19,680 --> 00:32:26,480
+adaptive learning مع علمmomentum صار عندي اختصار
+
+386
+00:32:26,480 --> 00:32:32,160
+لسه اكتر صرنا بنصل الى
+
+387
+00:32:32,160 --> 00:32:35,780
+ال zero
+
+388
+00:32:35,780 --> 00:32:41,280
+تقريبا error ومعناه مش zero هذا الكلام واحد اص نقص
+
+389
+00:32:41,280 --> 00:32:45,580
+اشهر اص نقص ثلاث يعني واحد من الألف يعني مش zero
+
+390
+00:32:46,700 --> 00:32:50,940
+مابدناش بالظبط 00 يعني ممكن تبقى صعب جدا انه ال
+
+391
+00:32:50,940 --> 00:32:56,100
+network تصل لل zero لكن ممكن نقبل بأنها تصل لواحد
+
+392
+00:32:56,100 --> 00:33:01,580
+من الف error ال error يصل لواحد من الف صح طيب ماشي
+
+393
+00:33:01,580 --> 00:33:06,000
+الحال okay الان هنا الكلام بيوصلنا لنهاية اللي
+
+394
+00:33:06,000 --> 00:33:08,920
+حاكي عن ال back propagation networks ولكن لأسف
+
+395
+00:33:08,920 --> 00:33:14,460
+ماقلش معنى وقت نبدأ في ال hub field ال hub field
+
+396
+00:33:14,460 --> 00:33:19,080
+networkو ال BAM فبناخدهم في المحاضرة الجاية ان شاء
+
+397
+00:33:19,080 --> 00:33:23,900
+الله تمام؟ يبقى احنا الآن عمليا باختصار المحاضرة
+
+398
+00:33:23,900 --> 00:33:28,940
+اليوم كانت تكملة ل ال back propagation networks
+
+399
+00:33:28,940 --> 00:33:33,960
+اللي هو واحد من أنواع ال unsupervised artificial
+
+400
+00:33:33,960 --> 00:33:36,680
+neural networks المحاضرة الجاية ان شاء الله بنكمل
+
+401
+00:33:36,680 --> 00:33:39,940
+النوعين التانيات اللي هو ال hot field و ال BAM
+
+402
+00:33:39,940 --> 00:33:46,360
+اللي هو في واقع الأمر نوع واحد بس منه نسختينو إذا
+
+403
+00:33:46,360 --> 00:33:49,600
+ضال معانا وجد نبدأ في ليش؟ في ال super .. في ال
+
+404
+00:33:49,600 --> 00:33:54,420
+unsupervised .. في ال unsupervised artificial
+
+405
+00:33:54,420 --> 00:33:55,140
+neural networks
+
diff --git a/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/bOV1o5ENro4.srt b/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/bOV1o5ENro4.srt
new file mode 100644
index 0000000000000000000000000000000000000000..d1ba158d850338f89d9cd253cd261bccf0ccb58e
--- /dev/null
+++ b/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/bOV1o5ENro4.srt
@@ -0,0 +1,1830 @@
+1
+00:00:20,700 --> 00:00:26,060
+بسم الله الرحمن الرحيم. اليوم نكمل على نفس الموضوع
+
+2
+00:00:26,060 --> 00:00:29,760
+المحاضرة الماضية، اللي هو الـ uncertainty management
+
+3
+00:00:29,760 --> 00:00:33,860
+and more basics for systems. وهذه هي المحاضرة
+
+4
+00:00:33,860 --> 00:00:38,100
+الثانية في هذا الموضوع. المحاضرة الأولى كانت في الـ
+
+5
+00:00:38,100 --> 00:00:42,770
+certainty factor theory.  مظبوط، وشوفنا كيف أن الـ
+
+6
+00:00:42,770 --> 00:00:45,910
+certainty factor لما دخل على الـ rules، لما صارت الـ
+
+7
+00:00:45,910 --> 00:00:50,050
+rules بيضاف إليها certainty factor، أيش هالأثر على
+
+8
+00:00:50,050 --> 00:00:54,630
+عملية الـ inference، وكيف صار أن الاستنتاجات أصبح
+
+9
+00:00:54,630 --> 00:01:01,830
+بكل استنتاج كيف بينحسب، وكيف بأنه بيصبح في عندي أنا
+
+10
+00:01:01,830 --> 00:01:05,970
+ممكن أكثر من استنتاج في قانون واحد. بقدر استنتاج أن
+
+11
+00:01:05,970 --> 00:01:09,130
+tomorrow is rain و tomorrow is dry، ولكن بالنسبة
+
+12
+00:01:09,130 --> 00:01:12,480
+متفاوتة. الآن هذا كمان برضه بيتكرر معنا هنا، بس
+
+13
+00:01:12,480 --> 00:01:15,300
+بأسلوب آخر، يعني نتعامل مع الـ uncertainty بأسلوب
+
+14
+00:01:15,300 --> 00:01:21,260
+آخر، اللي هو Bayesian Reasoning.  باشي بتذكروا أن هذه
+
+15
+00:01:21,260 --> 00:01:28,060
+المواضيع تبع الـ chapter ثلاثة، وأن احنا غطينا فيها
+
+16
+00:01:28,060 --> 00:01:31,780
+بلاطة من هنا، من ثلاثة لستة، بالأخرى احنا عملنا عادة
+
+17
+00:01:31,780 --> 00:01:35,100
+ترتيب للمواضيع بالشكل هذا. بنينا بالـ certainty
+
+18
+00:01:35,100 --> 00:01:38,630
+factor theory and Bayesian reasoning.  وأخذنا الـ
+
+19
+00:01:38,630 --> 00:01:41,090
+example اللي هو الـ forecast، اللي هو الـ application
+
+20
+00:01:41,090 --> 00:01:44,210
+على الـ certain factors، ووقفنا هذا الخط متقطع كان
+
+21
+00:01:44,210 --> 00:01:47,150
+نهاية المحاضرة الماضية. المحاضرة هي إن شاء الله
+
+22
+00:01:47,150 --> 00:01:54,090
+نبدأ من الشق الثاني من الـ chapter.  المفروض نبدأ بالـ
+
+23
+00:01:54,090 --> 00:01:56,150
+basic probability theory، وبعدها الـ Bayesian
+
+24
+00:01:56,150 --> 00:02:00,210
+reasoning، وناخد الـ example هذا نفسه هو الـ forecast
+
+25
+00:02:00,210 --> 00:02:04,250
+ولكن المرة هذه بتطبيق الـ Bayesian rule أو الـ
+
+26
+00:02:04,250 --> 00:02:11,540
+Bayesian reasoning على نفس الـ example. أحنا نبدأ لحد
+
+27
+00:02:11,540 --> 00:02:14,200
+ما نصل إلى الـ forecast. بعد كثرة دقائق معنا، واجدت
+
+28
+00:02:14,200 --> 00:02:18,020
+نكمل في الـ bias و الـ comparison. هدولة عبارة عن
+
+29
+00:02:18,020 --> 00:02:21,340
+ملاحظات بسيطة. إذا ما كفاش واجدت، بتخليها لمحاضرة
+
+30
+00:02:21,340 --> 00:02:26,480
+اللي بعد إن شاء الله، بس أنا برضه عشان واجدت، حابب
+
+31
+00:02:26,480 --> 00:02:29,980
+أنا أفلّت اللي هو الـ basic probability theory لأن
+
+32
+00:02:29,980 --> 00:02:34,290
+هو عبارة عن مبادئ، افترض أننا نعرفها في الـ
+
+33
+00:02:34,290 --> 00:02:39,910
+statistics وفي الـ probability، ونقدر ندخل على الـ
+
+34
+00:02:39,910 --> 00:02:43,150
+Bayesian reasoning مباشرة. الـ Bayesian reasoning
+
+35
+00:02:43,150 --> 00:02:48,590
+مباشرة، اللي هو سكشن ثلاثة ثلاثة، تمام، في الـ
+
+36
+00:02:48,590 --> 00:02:52,390
+Bayesian reasoning. أحنا نرجع مرة ثانية برضه الـ
+
+37
+00:02:52,390 --> 00:02:57,060
+rules اللي إننا بنضيف عليها. هناك كنا بنضيف
+
+38
+00:02:57,060 --> 00:03:00,720
+certainty factor، هنا بنضيف probability. probability
+
+39
+00:03:00,720 --> 00:03:09,540
+هذه برضه بتقول إن: if event E occurs، يعني حدث is
+
+40
+00:03:09,540 --> 00:03:16,000
+true، then probability أن الـ hypothesis H
+
+41
+00:03:20,540 --> 00:03:24,580
+ماشي، بس هو ممكن أنا أعتبره event، لأن هو event، ترتب
+
+42
+00:03:24,580 --> 00:03:31,160
+على event آخر. فالـ probability هذه معناها أنه إذا
+
+43
+00:03:31,160 --> 00:03:38,680
+حدث الـ E، فهحدث الـ H، هترتب على حدوث الـ H باحتمالية
+
+44
+00:03:38,680 --> 00:03:45,460
+بدرجة احتمال كذا P، تمام؟ هذا مدلول أن أنا أحط
+
+45
+00:03:45,460 --> 00:03:51,820
+probability للـ rule. Okay، الآن الـ probability هذه
+
+46
+00:03:51,820 --> 00:03:55,440
+احنا إذا بنذكر من الـ probability theory، فيها حاجة
+
+47
+00:03:55,440 --> 00:03:58,780
+اسمها الـ prior probability وحاجة اسمها الـ posterior
+
+48
+00:03:58,780 --> 00:04:02,420
+probability. الـ prior probability اللي هي المقصود
+
+49
+00:04:02,420 --> 00:04:11,260
+بها الـ probability تبع
+
+50
+00:04:11,260 --> 00:04:15,480
+حدوث الـ event بشكل مستقل في حد ذاته، والـ posterior
+
+51
+00:04:15,480 --> 00:04:18,540
+هي probability تبع حدوث الـ event
+
+52
+00:04:25,000 --> 00:04:28,920
+مش مرتبطة بحدوث event آخر. يعني مثلاً أنا لما بقعد
+
+53
+00:04:28,920 --> 00:04:33,380
+بقرا هذا الكلام، أيش بقول؟ probability of H given E
+
+54
+00:04:33,380 --> 00:04:37,980
+هذه الآن posterior ولا prior؟ أصبحت posterior، لأن
+
+55
+00:04:37,980 --> 00:04:42,560
+الـ posterior هي اللي probability تبع حدوث الـ event
+
+56
+00:04:42,560 --> 00:04:47,820
+اعتماداً على أو كنتيجة لـ، كنتيجة لحدوث event آخر.
+
+57
+00:04:47,820 --> 00:04:53,800
+وهذه الـ probability بتحسب بالمعادلة هذه، اللي هو أنه
+
+58
+00:04:54,130 --> 00:04:59,010
+بنجيب الـ prior probability، اللي هي قداش هذا الـ
+
+59
+00:04:59,010 --> 00:05:05,970
+event H أصلاً بيحدث في الدنيا، تمام؟ يعني أو بدون
+
+60
+00:05:05,970 --> 00:05:08,530
+نقول مثلاً، والله إن أنا واقف على باب
+
+61
+00:05:08,530 --> 00:05:15,190
+الجامعة، وبطلع الطالع اللي نازل، okay؟ بدي أعرف
+
+62
+00:05:15,190 --> 00:05:19,610
+إذا والله طالع طالب من باب الجامعة، والطالب هذا
+
+63
+00:05:19,610 --> 00:05:25,510
+حامل laptop معه، أيش احتمالية أن الطالب يكون طالب
+
+64
+00:05:25,510 --> 00:05:31,450
+كلية IT؟ يعني أيش الـ probability؟ هنا H أن الـ
+
+65
+00:05:31,450 --> 00:05:40,070
+student...
+
+66
+00:05:40,070 --> 00:05:44,510
+والـ event أيش؟
+
+67
+00:05:52,970 --> 00:05:56,970
+أيش الـ probability أن الـ student يكون طالب IT إذا
+
+68
+00:05:56,970 --> 00:06:06,550
+علم أنه حامل معه laptop؟ عشان أقدر هذه الاحتمالية،
+
+69
+00:06:06,550 --> 00:06:10,690
+أقدر هذه الاحتمالية لو شفت واحد حامل معه laptop،
+
+70
+00:06:10,690 --> 00:06:14,110
+أقدر قداش احتمالية أنه يكون هذا طالب IT؟ لازم أكون
+
+71
+00:06:14,110 --> 00:06:19,690
+عارف الآن، هذه الآن الأولاني، أيش احتمالية أن
+
+72
+00:06:19,690 --> 00:06:27,610
+لو واحد طالب IT يكون معه laptop؟ كيف بعرفها هذه؟
+
+73
+00:06:27,610 --> 00:06:32,330
+لازم أجيب كل طلاب الـ IT وأشوف قداش منهم نسبة
+
+74
+00:06:32,330 --> 00:06:37,110
+معهم laptop، صح؟ النسبة هذه هي probability ولا
+
+75
+00:06:37,110 --> 00:06:42,870
+لا؟ صح ولا لا؟ نسبة الطلاب الـ IT اللي معهم laptop
+
+76
+00:06:42,870 --> 00:06:45,950
+هذه هي probability، لأنه أصلاً أيش هي الـ
+
+77
+00:06:45,950 --> 00:06:50,670
+probability؟ لأنه أنا عندي علم عن الكل الموجود، ومن
+
+78
+00:06:50,670 --> 00:06:57,480
+خلال هذا الأمر بقدر أتوقع إنه لو في طالب IT، قداش
+
+79
+00:06:57,480 --> 00:07:01,900
+احتمال أن يكون معه laptop؟ قداش التوقع هذا؟ من
+
+80
+00:07:01,900 --> 00:07:05,920
+وين جاي التوقع هذا؟ جاي من هالمسبق، بعدد الطلاب
+
+81
+00:07:05,920 --> 00:07:12,140
+الـ IT اللي معهم الـ laptop. فلو كان أنا أعلم أن ٩٠٪
+
+82
+00:07:12,140 --> 00:07:15,960
+من طلاب الـ IT معهم الـ laptop، يبقى على طول بمجرد
+
+83
+00:07:15,960 --> 00:07:20,840
+ما أشوف طالب IT، هاقدر أقول إنه أنا أتوقع أن هذا
+
+84
+00:07:20,840 --> 00:07:25,660
+الطالب الشنطة تبعه يكون فيها laptop بنسبة ٩٠٪
+
+85
+00:07:25,660 --> 00:07:29,220
+probability، ٩٠٪، بس هذا لسه ما بيجاوبش على السؤال
+
+86
+00:07:29,220 --> 00:07:33,320
+يعني سؤالي مش هيك، سؤالي مش إنه إذا الطالب IT، أيش
+
+87
+00:07:33,320 --> 00:07:36,740
+احتمال إنه يكون معه laptop، أيش سؤالي؟ سؤالي إذا
+
+88
+00:07:36,740 --> 00:07:41,240
+أنا أشوف الطالب يحمل laptop، أيش احتمال إنه يكون
+
+89
+00:07:41,240 --> 00:07:47,260
+طالب IT؟ ممكن يكون يحمل laptop لكن ما هو، لكن
+
+90
+00:07:47,260 --> 00:07:50,620
+ما هو طالب IT، صح ولا لأ؟ ممكن يكون طالب هندسة، ممكن
+
+91
+00:07:50,620 --> 00:07:56,000
+يكون طالب شريعة، ولا لأ؟ بس أنا لأن عشان أجيب...
+
+92
+00:07:56,000 --> 00:08:05,860
+أجابه على هذا السؤال، احتمال أن يكون طالب IT إذا علم
+
+93
+00:08:05,860 --> 00:08:13,840
+أو إذا شوفت، يعني إنه يحمل laptop.
+
+94
+00:08:15,400 --> 00:08:18,640
+عشان أحسب هذا الكلام لازم أكون أيضاً عارف الكلام هذا
+
+95
+00:08:18,640 --> 00:08:26,800
+اللي هو، اللي هو أيش؟ من هذول قداش إذا علم أن هو طالب
+
+96
+00:08:26,800 --> 00:08:31,740
+IT، قداش احتمالية أن يكون معه، إنه عنده laptop؟  ضرب
+
+97
+00:08:31,740 --> 00:08:38,860
+أيش؟ أيش هذا؟ الـ probability of إنه يكون أصلاً طالب
+
+98
+00:08:38,860 --> 00:08:43,300
+IT؟ كيف هذه بدي أعرفها؟ بدي أجيب قول الله بالجامعة
+
+99
+00:08:43,300 --> 00:08:48,050
+اللي أنا واقف على بابها، وأعدهم كلهم، وأجيب كل
+
+100
+00:08:48,050 --> 00:08:51,150
+طلاب الـ IT وأعدهم كلهم، وأقسم هذا على هذا. إذا
+
+101
+00:08:51,150 --> 00:08:54,210
+عندي أنا طلاب الـ IT هم أربعمائة طالب، والجامعة
+
+102
+00:08:54,210 --> 00:08:57,750
+فيها ألف، يبقى أربعمائة على ألف، إذا فيها ألفين، إذا
+
+103
+00:08:57,750 --> 00:09:01,670
+فيها عشرين ألف، أربعمائة على عشرين ألف. هذه نسبة طلاب الـ
+
+104
+00:09:01,670 --> 00:09:10,890
+IT وهي برضه احتمالية أن يكون الطالب IT. فهذا
+
+105
+00:09:10,890 --> 00:09:14,630
+كلام عن أيضاً
+
+106
+00:09:14,880 --> 00:09:20,540
+إنه العكس منه، اللي هو إنه إذا كان معه laptop، قداش
+
+107
+00:09:20,540 --> 00:09:24,460
+احتمالية إنه هو مش طالب IT، وقداش احتمالية اللي مش
+
+108
+00:09:24,460 --> 00:09:28,120
+طلاب الـ IT كلهم، اللي هم الباقية الأخرى من الـ... من
+
+109
+00:09:28,120 --> 00:09:33,580
+الـ... هذا الكلام كله، كله من أوله لآخره، بيعتمد على
+
+110
+00:09:33,580 --> 00:09:38,800
+statistics. أنا عشان أقدر الكمية هذه أو الاحتمالية
+
+111
+00:09:38,800 --> 00:09:42,090
+هذه، لازم يكون عندي المعلومات هذه، والمعلومات هذه من
+
+112
+00:09:42,090 --> 00:09:45,230
+وين بتيجي؟ أنا توقفت وأنا بحكي، أيش كنت بقول؟ كنت بقول
+
+113
+00:09:45,230 --> 00:09:48,410
+أنه لازم يكون في عندي عدد هذول عشان أقسم على عدد
+
+114
+00:09:48,410 --> 00:09:51,650
+الإجمالي، والنسبة هذه هي... طب أنا من وين بجيب هذا
+
+115
+00:09:51,650 --> 00:09:55,410
+الكلام؟ بجيبه من statistics. الـ Bayesian، الـ Bayesian
+
+116
+00:09:55,410 --> 00:09:59,710
+rule تستند هي على probability theory، صح؟ أو probability
+
+117
+00:09:59,710 --> 00:10:05,470
+rule، مظبوط، بس تستند إليها، شالت statistical data، و
+
+118
+00:10:05,470 --> 00:10:08,790
+هذا أصلاً اللي بيخلينا دائماً ندرس الـ statistics، الـ
+
+119
+00:10:08,790 --> 00:10:14,230
+statistics والـ probability مع بعض، صح ولا تمام؟ لأن
+
+120
+00:10:14,230 --> 00:10:18,730
+لأن
+
+121
+00:10:18,730 --> 00:10:23,430
+هنا الكلام، أحياناً أنا بكون في عندي عدة احتمالات، و
+
+122
+00:10:23,430 --> 00:10:26,490
+بكون عندي عدة events. يعني مثلاً أنا ممكن أكون عندي
+
+123
+00:10:26,490 --> 00:10:31,960
+event واحد، الـ event الواحد هذا، وأنا بدي أحسب أنه
+
+124
+00:10:31,960 --> 00:10:35,720
+أنا شايف الطالب طالع من باب الجامعة، ويحمل laptop،
+
+125
+00:10:35,720 --> 00:10:39,800
+بدي أحسب قداش احتمالية أنه طالب IT، وأيضاً بدي أحسب
+
+126
+00:10:39,800 --> 00:10:43,760
+قداش احتمالية أنه طالب هندسة، وأيضاً ربما بدي أحسب
+
+127
+00:10:43,760 --> 00:10:48,780
+احتمال ثالث، أن قداش الطالب طالب شريعة مثلاً، هدول
+
+128
+00:10:48,780 --> 00:10:57,000
+different H's، صح؟ كل واحد منهم بتسميه H1، H2، H
+
+129
+00:10:57,000 --> 00:11:06,600
+ثلاثة. بدي أحسب احتمالية كل واحد منهم إذا علم أن
+
+130
+00:11:06,600 --> 00:11:14,320
+هذا الطالع من باب الجامعة يحمل الـ E، أن هو حامل
+
+131
+00:11:14,320 --> 00:11:19,320
+laptop. طبعاً أنا مش عندي H واحدة، عندي أكثر من الـ H.
+
+132
+00:11:19,320 --> 00:11:22,740
+الـ H الأولى إنه IT student، الـ H الثانية إنه
+
+133
+00:11:22,740 --> 00:11:26,140
+engineering student، الـ H الثالثة إنه شريعة student.
+
+134
+00:11:26,340 --> 00:11:30,600
+Okay. فالـ probabilities هذه، أنا في حال وجود عدة
+
+135
+00:11:30,600 --> 00:11:36,280
+hypotheses، ألاقي هذه hypothesis واحدة، تمام؟ فأروح
+
+136
+00:11:36,280 --> 00:11:39,880
+بأحسب للـ hypothesis اللي أنا بدي إياها، اللي هو one
+
+137
+00:11:39,880 --> 00:11:46,800
+أو اثنين أو ثلاثة. البسط زي ما هو، بس في المقام زي
+
+138
+00:11:46,800 --> 00:11:54,600
+ما أنا كانت هنا عندي مجرد حدين، اللي هو التوقع
+
+139
+00:11:54,600 --> 00:11:59,180
+ورقة ونقيضه. أنا الآن في عندي ثلاثة توقعات، ثلاثة
+
+140
+00:11:59,180 --> 00:12:05,520
+hypotheses. فهم هتبقى بتضرب كل واحد الـ posterior
+
+141
+00:12:05,520 --> 00:12:09,960
+probability بالـ prior probability، وأجمع على اللي
+
+142
+00:12:09,960 --> 00:12:15,120
+الـ hypothesis الثانية ثم الثالثة، ثم الثالثة. واضح يعني
+
+143
+00:12:15,120 --> 00:12:20,440
+هذه المعادلة اللي أنا بقدر أفكها على شكل أيش؟ إن
+
+144
+00:12:20,440 --> 00:12:26,570
+probability of E given H واحد، E H1 ضرب
+
+145
+00:12:26,570 --> 00:12:31,390
+probability of H1. علشان أحسب الـ probability أنه الـ
+
+146
+00:12:31,390 --> 00:12:36,730
+probability تبعت H1، على أيش بقسم؟ كم H أنا عندي؟
+
+147
+00:12:36,730 --> 00:12:44,230
+ثلاثة. بدي أعمل ثلاثة terms، كل term هو عبارة عن
+
+148
+00:12:44,230 --> 00:12:54,320
+probability of E H1 ضرب probability of H1.  ذكر أن
+
+149
+00:12:54,320 --> 00:12:58,720
+probability of H1 هي الـ prior probability، نفس
+
+150
+00:12:58,720 --> 00:13:04,700
+الكلام بس على H2 ونفس الكلام على H3. هذا لما يكون
+
+151
+00:13:04,700 --> 00:13:09,180
+عندي single evidence أو event أو evidence، وبدي
+
+152
+00:13:09,180 --> 00:13:12,860
+أحسب لـ multiple hypotheses الـ probabilities تبعتهم.
+
+153
+00:13:12,860 --> 00:13:17,760
+أحياناً يجب أن يكون عندي multiple evidences و
+
+154
+00:13:17,760 --> 00:13:22,190
+multiple hypotheses. يعني مطلب الـ evidences ومطلب الـ
+
+155
+00:13:22,190 --> 00:13:31,330
+hypotheses وكذا event، العلاقة بيصبح أن أنا بدي أجيب
+
+156
+00:13:31,330 --> 00:13:39,270
+نفس الكلام اللي تحت، وخلينا نشوف مثال عملي على هذا،
+
+157
+00:13:39,270 --> 00:13:44,150
+وبعدين بنرجع للـ formula هذا اللي أنا قاعد
+
+158
+00:13:44,150 --> 00:13:48,190
+هنا في المثال هذا، أيش اللي هن...
+
+159
+00:13:53,450 --> 00:14:04,670
+مفترض أن الـ expert في عندي ثلاثة... في عندي ثلاثة
+
+160
+00:14:04,670 --> 00:14:10,130
+hypotheses، هذا H1 وهذا H2، طبعاً أن I بيساوي واحد، I
+
+161
+00:14:10,130 --> 00:14:12,970
+بيساوي اثنين، I بيساوي ثلاثة. يعني المفهوم أن الـ I
+
+162
+00:14:12,970 --> 00:14:21,330
+هي الـ subscript من H هذا، H3، الـ... الـ... الـ...
+
+163
+00:14:21,330 --> 00:14:27,400
+الصورة هذا هو يبقى عن H. الـ prior probability تبع كل
+
+164
+00:14:27,400 --> 00:14:33,340
+واحد من الـ H، يعني هذا الـ prior probability تبع H1
+
+165
+00:14:33,340 --> 00:14:36,880
+والـ prior probability تبع H2 وH3. هنا الـ
+
+166
+00:14:36,880 --> 00:14:42,540
+probability تبع الـ H، يعني الـ H1 لحد حدوث الـ event
+
+167
+00:14:42,540 --> 00:14:49,740
+E1. إذا، إذا أيش احتمال؟ إذا عُلم الـ hypothesis هذا،
+
+168
+00:14:49,740 --> 00:14:53,600
+أيَش احتمال يكون بسبب الـ event
+
+169
+00:14:55,320 --> 00:14:59,980
+أحنا الآن هذا... لأ أحنا... عدي أنا رابط كل event
+
+170
+00:14:59,980 --> 00:15:04,180
+...كل hypothesis بـ event. هذا hypothesis one بـ
+
+171
+00:15:04,180 --> 00:15:08,860
+event one. هذا hypothesis اثنين بـ event one، صح؟
+
+172
+00:15:08,860 --> 00:15:11,020
+فالصورة هذا
+
+173
+00:15:16,210 --> 00:15:21,310
+هو عبارة عن الـ posterior probability،  لأمين لهذه
+
+174
+00:15:21,310 --> 00:15:24,050
+الـ hypothesis مع event واحد، واللي بعده مع event
+
+175
+00:15:24,050 --> 00:15:26,950
+اثنين، واللي بعده مع event ثلاثة. ماهو المطلوب؟
+
+176
+00:15:26,950 --> 00:15:33,890
+المطلوب أن أنا أحسب إذا عُلم الـ evidence الـ E واحد
+
+1
+
+223
+00:19:54,740 --> 00:19:57,980
+واسهل لأن أنا بضرب الكمية بحسب هذه الكمية في الأول
+
+224
+00:19:57,980 --> 00:20:03,120
+وبعدين بجيب أنا بحسب الكميات الثلاثة داخلها و
+
+225
+00:20:03,120 --> 00:20:06,300
+بعدين بجيب مجموعها صح؟ أنا بجيب مجموع الأول على المجموع
+
+226
+00:20:06,300 --> 00:20:09,320
+الثاني على المجموع، الثالث على المجموع، وخلصت هذا
+
+227
+00:20:09,320 --> 00:20:14,680
+بس الآن إذا لسه إحنا بنعرف بس الـ E ثلاثة بس الـ E
+
+228
+00:20:14,680 --> 00:20:20,210
+ثلاثة، افترض أن بعد ذلك لاحظنا ملاحظة أخرى، وأصبح
+
+229
+00:20:20,210 --> 00:20:25,650
+لدي الملاحظة اثنين اثنين اثنين
+
+230
+00:20:25,650 --> 00:20:35,390
+اثنين
+
+231
+00:20:35,390 --> 00:20:40,850
+اثنين
+
+232
+00:20:40,850 --> 00:20:44,570
+اثنين اثنين اثنين اثنين اثنين اثنين اثنين اثنين
+
+233
+00:20:44,570 --> 00:20:51,210
+اثنين اثنين اثنين اثنين اثنين اثنين اثنين صحيح إذا
+
+234
+00:20:51,210 --> 00:20:57,770
+نضرب ثلاثة مقادير، نفس القاعدة، إذا كنا نضرب مقدارين
+
+235
+00:20:57,770 --> 00:21:04,850
+فهنا نضرب ثلاثة مقادير، الثلاثة مقادير اللي هم P of H
+
+236
+00:21:04,850 --> 00:21:10,890
+مضروبة في الـ posterior H مع E1 مضروبة في الـ
+
+237
+00:21:10,890 --> 00:21:17,820
+posterior H مع E3، اللي هم رجعتنا للجدول هذه الـ
+
+238
+00:21:17,820 --> 00:21:23,760
+prior، وهذه الـ posterior تبع h1، وهذه الـ posterior
+
+239
+00:21:23,760 --> 00:21:30,660
+تبع h1 مع E3، ليه هذا، وh1 ليها هذول ثلاثة مقابلة
+
+240
+00:21:30,660 --> 00:21:36,180
+الضرب هذا البسط الأول، واللي مقابلهم البسط الثاني
+
+241
+00:21:36,180 --> 00:21:42,400
+واللي مقابلهم البسط الثالث، صح ولا لأ؟ هاي بدي أروح
+
+242
+00:21:42,400 --> 00:21:48,190
+الـ slide هاي، البسط الأول، هذا هو البسط الثاني، وهذا
+
+243
+00:21:48,190 --> 00:21:55,290
+هو البسط الثالث، صح؟
+
+244
+00:21:55,290 --> 00:21:58,710
+لأننا
+
+245
+00:21:58,710 --> 00:22:02,110
+لم نعمل أي calculation، لأننا لم نحسب أي أرقام، نرجع
+
+246
+00:22:02,110 --> 00:22:05,450
+الآن لننظر إلى الأرقام ونحاول أن نفهم أي شيء
+
+247
+00:22:05,450 --> 00:22:10,310
+الأرقام اللي طلعت عندما كان بس E3 هو المعلوم كان
+
+248
+00:22:10,310 --> 00:22:15,750
+هكذا، أيش معنى هذا الرقم؟ إنه احتمالية أن يكون
+
+249
+00:22:15,750 --> 00:22:19,570
+hypothesis واحدة true عندما كنا نعلم أنها ثلاثة
+
+250
+00:22:19,570 --> 00:22:23,890
+فقط، كان احتمالها أربعة وثلاثين، والثاني هي
+
+251
+00:22:23,890 --> 00:22:26,390
+hypothesis تقريبا أربعة وثلاثين، وهذا اثنين وثلاثين
+
+252
+00:22:26,390 --> 00:22:32,130
+فأنا في يدي two hypotheses، فرضيتين، لهم نفس المستوى
+
+253
+00:22:32,130 --> 00:22:36,490
+أو نفس القيمة من ناحية الاحتمال، بقدر أتوقعهم بنفس
+
+254
+00:22:36,490 --> 00:22:43,950
+النسبة، وهذا أقل منه، لأن لما أضفنا الـ event E واحد
+
+255
+00:22:44,580 --> 00:22:48,340
+يفترض هذه المعلومة الجديدة أو هذه الملاحظة الجديدة
+
+256
+00:22:48,340 --> 00:22:53,360
+ترجح كفة أحد الاحتمالات على الأخرى، وهذا فعلا اللي
+
+257
+00:22:53,360 --> 00:23:00,600
+طلع هنا أن E2 زادت الـ probability تبعها، وهذا انخفض
+
+258
+00:23:00,600 --> 00:23:04,520
+وهذا انخفض بشدة، أكثر من... مش كان أربعة وثلاثين
+
+259
+00:23:04,520 --> 00:23:08,040
+هذا، وبعدين ثلاثين، هذا انخفض بنسبة 3%، وهذا انخفض
+
+260
+00:23:08,040 --> 00:23:11,560
+بنسبة كبيرة اللي هي 5.15
+
+261
+00:23:13,750 --> 00:23:18,030
+فقد إيش إحنا معلومات بنجمعها أو events، الملاحظات
+
+262
+00:23:18,030 --> 00:23:22,450
+يعني بنلاحظها بترجح كفة الاحتمالات اللي عندنا، لو
+
+263
+00:23:22,450 --> 00:23:28,330
+عندي معلومة واحدة بيصعب أن أميز أو أرجح كفة أحد
+
+264
+00:23:28,330 --> 00:23:31,790
+الاحتمالات على الآخر، أحد الـ hypotheses على الآخر
+
+265
+00:23:31,790 --> 00:23:36,070
+صح أو لأ؟ الآن لو تلاحظ لما بعد ذلك دخلنا الـ E2
+
+266
+00:23:36,070 --> 00:23:42,480
+في الحسبة، صرنا أولًا بنضرب مين؟ أربعة، أي نعم، هم
+
+267
+00:23:42,480 --> 00:23:45,440
+الباصلة، وهم اللي بدخلوا في المقام، لأن إيش اللي
+
+268
+00:23:45,440 --> 00:23:49,560
+لاحظ أن واحدة أصبح تباين الصوت، مع أنه كان عالية و
+
+269
+00:23:49,560 --> 00:23:53,760
+كان على واحد في ظل أي واحد أو أي ثلاثة، لأن لما جاء
+
+270
+00:23:53,760 --> 00:23:58,900
+اثنين واثنين اثنين، رجح كفة تميز هذا أو هذه هذه
+
+271
+00:23:58,900 --> 00:24:01,880
+هذه هذه هذه هذه هذه هذه هذه هذه هذه هذه هذه
+
+272
+00:24:01,880 --> 00:24:03,200
+هذه هذه هذه هذه هذه هذه هذه هذه هذه هذه هذه
+
+273
+00:24:03,200 --> 00:24:03,360
+هذه هذه هذه هذه هذه هذه هذه هذه هذه هذه هذه
+
+274
+00:24:03,360 --> 00:24:04,280
+هذه هذه هذه
+
+275
+00:24:06,740 --> 00:24:11,640
+Okay، الآن الكلام لسه ما يبقى نفس الـ rules في الموضوع
+
+276
+00:24:11,640 --> 00:24:17,040
+هذه اللي هو الـ Bayesian rule في حساب الـ
+
+277
+00:24:17,040 --> 00:24:21,640
+probabilities تبعت إيش؟ تبعت الـ hypotheses المختلفة
+
+278
+00:24:21,640 --> 00:24:28,240
+في ظل وجود events متعددة، طبعا إحنا ما عندناش وجهة
+
+279
+00:24:28,240 --> 00:24:33,270
+نشوف، لو أنا عندي... إحنا إحنا عملية، لأن... لأ عملية
+
+280
+00:24:33,270 --> 00:24:36,390
+إحنا شفنا multiple events و multiple hypotheses
+
+281
+00:24:36,390 --> 00:24:41,570
+صح ولا لأ؟ هذا المثال عبارة عن تعدد hypotheses و
+
+282
+00:24:41,570 --> 00:24:49,270
+تعدد events، ف... بس برجع يعني بقول أن هذه الطريقة
+
+283
+00:24:49,270 --> 00:24:53,210
+أو الـ method في حساب الـ probability بتستند إلى
+
+284
+00:24:53,210 --> 00:24:59,350
+وجود statistics شاملة، بدي statistics عن... prior
+
+285
+00:24:59,350 --> 00:25:03,290
+statistics عن كل الـ hypotheses، و posterior
+
+286
+00:25:03,290 --> 00:25:07,050
+statistics عن كل واحد من الـ hypotheses في ظل كل
+
+287
+00:25:07,050 --> 00:25:12,230
+واحد من الـ events، هذا الكلام ربما بده إيش؟ بده
+
+288
+00:25:12,230 --> 00:25:19,160
+هيئة الإحصاء العامة تجيب البيانات، وتجيب لكل شيء
+
+289
+00:25:19,160 --> 00:25:23,960
+تمام؟ عشان هيك إحنا ما بنقدرش نستخدم الـ base and
+
+290
+00:25:23,960 --> 00:25:26,640
+rule إلا إذا توفرت الـ statistics، ما توفرش
+
+291
+00:25:26,640 --> 00:25:30,900
+statistics، بدنا نستند إلى التخمين تبع الـ human
+
+292
+00:25:30,900 --> 00:25:34,680
+expert، الـ human expert هو بيعطيني certain effect
+
+293
+00:25:34,680 --> 00:25:39,460
+من تجربته، بيقول لي أن والله عادة إذا الطالب بيحمل
+
+294
+00:25:39,460 --> 00:25:44,920
+شنطة كده، فغالبا هو... غالبا أو يعني باحتمال كده
+
+295
+00:25:45,170 --> 00:25:48,010
+كلمة احتمال هذه إحنا بنحولها إلى رقم زي ما شفنا
+
+296
+00:25:48,010 --> 00:25:52,690
+في المحاضرات، بيبقى جدول هنا، بيبقى جدول هنا،
+
+297
+00:25:52,690 --> 00:25:54,330
+بيبقى جدول هنا، بيبقى جدول هنا، بيبقى جدول هنا، بيبقى
+
+298
+00:25:54,330 --> 00:25:56,110
+جدول هنا، بيبقى جدول هنا، بيبقى جدول هنا، بيبقى جدول
+
+299
+00:25:56,110 --> 00:25:56,550
+هنا، بيبقى جدول هنا، بيبقى جدول هنا، بيبقى جدول
+
+300
+00:25:56,550 --> 00:25:56,590
+بيبقى جدول هنا، بيبقى جدول هنا، بيبقى جدول هنا، بيبقى
+
+301
+00:25:56,590 --> 00:25:58,890
+جدول هنا، بيبقى جدول هنا، بيبقى جدول هنا، بيبقى جدول
+
+302
+00:25:58,890 --> 00:26:05,750
+هنا، بيبقى جدول هنا، بيبقى
+
+303
+00:26:05,750 --> 00:26:14,490
+جدول
+
+304
+00:26:14,490 --> 00:26:18,340
+ما، هنستخدم الـ Bayesian probability، هنستخدمها في
+
+305
+00:26:18,340 --> 00:26:22,000
+rule based system، إحنا الآن نحكي عن expert system
+
+306
+00:26:22,000 --> 00:26:25,360
+ما نحكيش عن عملية إحصائية، وعملية probability و
+
+307
+00:26:25,360 --> 00:26:30,940
+statistics، فإحنا بدنا ندمج مسألة الـ probability في
+
+308
+00:26:30,940 --> 00:26:34,760
+الـ rule based expert systems، بدنا نعطي زي ما
+
+309
+00:26:34,760 --> 00:26:38,740
+رجعنا، زي ما كنا شفنا قبل هيك، نعطي للـ rule في
+
+310
+00:26:38,740 --> 00:26:43,120
+بداية الحكي، نعطي للـ rule probability، وعلى أساس الـ
+
+311
+00:26:43,120 --> 00:26:46,820
+probability هذه نحسب الاحتمالات، ونعمل inference
+
+312
+00:26:46,820 --> 00:26:51,920
+ونحسب إيش؟ الاستنتاج
+
+313
+00:26:51,920 --> 00:26:54,800
+اللي ممكن نوصله على set of factors
+
+314
+00:26:57,990 --> 00:27:00,590
+إحنا الـ certainty factor كان بعتمد على نظرية الـ
+
+315
+00:27:00,590 --> 00:27:04,030
+certainty factor، certainty factor theory، إحنا الآن
+
+316
+00:27:04,030 --> 00:27:08,870
+بنعتمد على الـ probability في إيش؟ في الـ rule based
+
+317
+00:27:08,870 --> 00:27:14,130
+يعني استنادا إلى الـ probability، بناخد الـ
+
+318
+00:27:14,130 --> 00:27:18,210
+probability، ونشوف كيف أنا ممكن أدمجها في الـ rule
+
+319
+00:27:18,210 --> 00:27:20,850
+based expert system، إحنا هناك دمجنا الـ certainty
+
+320
+00:27:20,850 --> 00:27:23,710
+factor في الـ rule based expert system، فبدي
+
+321
+00:27:23,710 --> 00:27:26,490
+تركزوا معايا شوية، لأن إحنا الـ rules الآن هنصير
+
+322
+00:27:26,490 --> 00:27:32,770
+شكلها شوية مختلفة، نحكي عن الـ rules، الـ rule البسيطة
+
+323
+00:27:32,770 --> 00:27:36,530
+اللي كانت بتقول إذا today is rain، tomorrow is rain
+
+324
+00:27:36,530 --> 00:27:41,830
+أو إذا today is dry، tomorrow is dry، بدنا نعطيها
+
+325
+00:27:41,830 --> 00:27:46,790
+probability، وبدنا نعطيها كمان حاجتين أخرتين، هذا الـ
+
+326
+00:27:46,790 --> 00:27:54,050
+rule بتفسير، إذا today is rain، نعطيها الرقمين هذول
+
+327
+00:27:54,050 --> 00:27:58,650
+الـ Ls والـ Ln، واللي أنا بوضحهم إيش هم، وأن
+
+328
+00:27:58,650 --> 00:28:02,050
+أنا أعطيها برضه كمان لـ prior probability، هد الـ
+
+329
+00:28:02,050 --> 00:28:04,790
+prior probability واضحة، إيش معناها؟ يعني tomorrow
+
+330
+00:28:04,790 --> 00:28:09,150
+is dry، هد بتقول لي أنه إذا today is dry، ف tomorrow
+
+331
+00:28:09,150 --> 00:28:14,290
+is dry باحتمال 50%، 50% من هذه اللي بيكون اليوم
+
+332
+00:28:14,290 --> 00:28:17,950
+اللي ما فيهوش مطر بيكون بكرا برضه ما فيهوش مطر
+
+333
+00:28:17,950 --> 00:28:24,680
+صح؟ هد هي استنادة إحصائية، وهي أبدا احتمالي، وهنا
+
+334
+00:28:24,680 --> 00:28:28,680
+العكس، أن إذا today rain بيكون tomorrow is rain
+
+335
+00:28:28,680 --> 00:28:34,880
+فهذا الـ priority، إيش الآن الـ Ls والـ Ln، هدول و
+
+336
+00:28:34,880 --> 00:28:38,880
+مين اللي بيحطهم؟ إيش دلالتهم؟ ومن وين بنجيبهم إحنا؟
+
+337
+00:28:38,880 --> 00:28:44,340
+الـ Ls مقصود بيه هو likelihood of sufficiency، هو
+
+338
+00:28:44,340 --> 00:28:50,860
+عبارة عن رقم بيحطه الـ human expert، بيدل من خلاله
+
+339
+00:28:50,860 --> 00:28:56,340
+على درجة اعتقاده هو بأنه هذا كلامه، إن إذا اليوم
+
+340
+00:28:56,340 --> 00:29:01,200
+رمضان، فأمس سيكون رمضان، إنه إذا تحقق هذا الـ event
+
+341
+00:29:01,200 --> 00:29:07,880
+ماشي، هو بيعتقد أن تحققه يصب بشكل قوي في تحقق هذا
+
+342
+00:29:07,880 --> 00:29:12,540
+الـ computer هذا، يعني الـ human expert، فالـ high
+
+343
+00:29:12,540 --> 00:29:17,860
+values of LS، اللي هو likelihood of sufficiency، high
+
+344
+00:29:17,860 --> 00:29:21,360
+value، يعني أكبر من واحد بكثير، indicate that the
+
+345
+00:29:21,360 --> 00:29:26,280
+rule strongly supports the hypothesis، إذا الـ
+
+346
+00:29:26,280 --> 00:29:33,000
+evidence تحقق، إذا الـ evidence تحقق، فإيش؟ هذا بي...
+
+347
+00:29:33,000 --> 00:29:37,760
+طيب، لو ما تحققش، هل معناه ذلك أنه منعدم تماما؟ يعني
+
+348
+00:29:37,760 --> 00:29:41,840
+إذا ما كانش اليوم rain، هل منعدم تماما احتمالية أنه
+
+349
+00:29:41,840 --> 00:29:47,400
+بكرا يكون rain؟ لأ، ورده، وهذا هو اللي جدّش ورده بين
+
+350
+00:29:47,400 --> 00:29:52,140
+إيش؟ بنعبر عنها بهذا الرقم، هذا الرقم منخفض، أقل من
+
+351
+00:29:52,140 --> 00:29:56,200
+واحد، هذا الرقم بحقه الـ human expert بيقصد فيه إن
+
+352
+00:29:56,200 --> 00:29:59,700
+إيش؟ أن والله في احتمال، صح؟ في احتمال أن هذا اللي
+
+353
+00:29:59,700 --> 00:30:04,460
+لم يتحقق، أن اليوم مار مار مار مار مار مار مار مار
+
+354
+00:30:04,460 --> 00:30:04,820
+مار مار مار مار مار مار مار مار مار مار مار
+
+355
+00:30:04,820 --> 00:30:05,280
+مار مار مار مار مار مار مار مار مار مار مار
+
+356
+00:30:05,280 --> 00:30:06,380
+مار مار مار مار مار مار مار مار مار مار مار
+
+357
+00:30:06,380 --> 00:30:06,600
+مار مار مار مار مار مار مار مار مار مار مار
+
+358
+00:30:06,600 --> 00:30:06,900
+مار مار مار مار مار مار مار مار مار مار مار
+
+359
+00:30:06,900 --> 00:30:14,740
+مار مار
+
+360
+00:30:14,740 --> 00:30:22,870
+مار، أقل بكثير من احتمال، أقل بكثير من ثقتنا بأنه
+
+361
+00:30:22,870 --> 00:30:29,070
+أنه إذا كان اليوم rain بكرا هيكون rain، ماشي، هنا الـ
+
+362
+00:30:29,070 --> 00:30:32,150
+rule الثاني إيش أصلا بيقول؟ today is dry، فبكرا dry
+
+363
+00:30:32,150 --> 00:30:39,190
+الرقم هذا 1.6 بيقول، بيشير إلى أن الـ human expert
+
+364
+00:30:39,190 --> 00:30:44,740
+بيعتقد أنه إذا today is dry، ففعلا بكرا هيكون dry، و
+
+365
+00:30:44,740 --> 00:30:50,440
+ب... و ب... و بدرجة يعني توقع شديدة، مش شديدة
+
+366
+00:30:50,440 --> 00:30:56,860
+كثير، لأنه عمليًا عمليًا ممكن يجي أيام كثيرة جدًا rain و
+
+367
+00:30:56,860 --> 00:31:01,340
+لكن أكثر يبقى rain، بس... بس بالأغلب لو اليوم rain
+
+368
+00:31:01,340 --> 00:31:05,420
+الناس بتتوقع أنه برضه بكرا هيكون rain، صح؟ على
+
+369
+00:31:05,420 --> 00:31:09,840
+جانب في شوية مطر، بواجهة ما كملتش في اليوم هذا، يكون
+
+370
+00:31:09,840 --> 00:31:16,730
+مضايق اللي بدأت تنزل مبكرًا، هنا إذا dry يوم، اه
+
+371
+00:31:16,730 --> 00:31:23,250
+بنستبعد أن يكون بكرا فيه rain، okay، بس الاحتمال...
+
+372
+00:31:23,250 --> 00:31:26,970
+الاحتمال أنه إذا بكرا dry يكون... إذا اليوم dry
+
+373
+00:31:26,970 --> 00:31:31,950
+بكرا يكون dry وارد، ولكن مش بقوة اللي هو حد المقرر، و
+
+374
+00:31:31,950 --> 00:31:34,950
+هنا العكس، ليش... كيف نفهم اللي أعرفه في المجلد
+
+375
+00:31:34,950 --> 00:31:39,410
+الآن أنه if today is إيش؟ هي دي في حد ما يكون الـ
+
+376
+00:31:39,410 --> 00:31:43,510
+evidence false، في حال ما يكون الـ rain، إيش يعني الـ
+
+377
+00:31:43,510 --> 00:31:46,650
+event، و أتفق، يعني today is rain، في حال ما يكون الـ
+
+378
+00:31:46,650 --> 00:31:49,930
+rain، إيش احتمال أن يكون بكرا؟ دلوقت وارد، بس
+
+379
+00:31:49,930 --> 00:31:55,890
+بنسبة إيش؟ أربعين في المئة تقريبا، احتمال يكون
+
+380
+00:31:55,890 --> 00:32:01,100
+بنسبة خمسين في المئة، هذه الـ 50% هذه
+
+381
+00:32:01,100 --> 00:32:03,740
+اللي هي بدون أي شروط، بدون أي evidence، فماذا يعني
+
+382
+00:32:03,740 --> 00:32:06,920
+شريط الخمسة في point 3؟ الخمسة هذه أنه بصفة عامة
+
+383
+00:32:06,920 --> 00:32:10,260
+إحنا دلوقتي هم الخمسة هذه إنهم الـ experts، بالظبط
+
+384
+00:32:10,260 --> 00:32:13,620
+هذه initial priority، ممكن تيجي من الـ statistics أو
+
+385
+00:32:13,620 --> 00:32:18,160
+تنحط عشوائيًا، هتتعدل مع الـ، مع الحسب بناء على
+
+386
+00:32:18,160 --> 00:32:22,680
+المعطيات اللي هنا، فالآن خلي بالك الـ system هذا هو
+
+387
+00:32:22,680 --> 00:32:30,080
+يشتغل بالـ rules هذه، الـ rules، بدأنا نحط هذه الـ rule
+
+388
+00:32:30,080 --> 00:32:31,740
+بقى واحدة، رقم اثنين، اللي قبلها رقم اثنين، اللي
+
+389
+00:32:31,740 --> 00:32:32,120
+قبلها رقم اثنين، اللي قبلها رقم اثنين، اللي قبلها
+
+390
+00:32:32,120 --> 00:32:34,900
+رقم اثنين، اللي قبلها رقم اثنين، اللي قبلها رقم
+
+391
+00:32:34,900 --> 00:32:35,940
+اثنين، اللي قبلها رقم اثنين، اللي قبلها رقم اثنين
+
+392
+00:32:35,940 --> 00:32:36,400
+اللي قبلها رقم اثنين، اللي قبلها رقم اثنين، اللي
+
+393
+00:32:36,400 --> 00:32:41,380
+رقم اثنين، اللي قبلها رقم اثنين، اللي قبلها رقم
+
+394
+00:32:41,380 --> 00:32:49,960
+اثنين اللي قبلها رقم
+
+395
+00:32:49,960 --> 00:32:57,590
+ألقى أن rule الطبقات يجب أن يستنتج منها بس است
+
+445
+00:37:17,100 --> 00:37:21,600
+بضربها في الـ S صح؟ أنا أجعل الـ event true ولا لأ؟
+
+446
+00:37:21,600 --> 00:37:25,000
+إنه today ليه true؟ لأ، رايحين نقول لأنه أنا أجيب إجابة
+
+447
+00:37:25,000 --> 00:37:30,640
+الـ user اللي جايبني، فبضرب في إيش؟ في الـ S، الـ L، S
+
+448
+00:37:30,640 --> 00:37:37,680
+2.5 مظبوط، 2.5 في مين؟ بضرب في الـ
+
+449
+00:37:37,680 --> 00:37:40,860
+watch لأن حساب اللي أنا ليه الـ one بتصير two point
+
+450
+00:37:40,860 --> 00:37:46,280
+five ماشي الحال. الآن وصلت للمرحلة الأخيرة اللي هي
+
+451
+00:37:46,280 --> 00:37:52,700
+probability of H given E اللي هي عبارة عن إيش؟
+
+452
+00:37:52,700 --> 00:37:59,580
+اللي هي عبارة عن هذا على واحد زائد نفسه، صح؟ 2.5
+
+453
+00:37:59,580 --> 00:38:06,500
+على واحد زائد 2.5 يساوي 2.5 على 3.5 يساوي اللي هو
+
+454
+00:38:06,500 --> 00:38:14,670
+0.7. شو هذا الرقم؟ probability جديد لهذا الاحتمال، أو
+
+455
+00:38:14,670 --> 00:38:19,670
+لهذا الـ hypothesis، صح؟ لأن أنا بسجل هذه الدالة إنه
+
+456
+00:38:19,670 --> 00:38:26,790
+الـ hypothesis H اللي هو إن tomorrow tomorrow is
+
+457
+00:38:26,790 --> 00:38:33,670
+غير الـ probability تبعته، فهذا الكلام بيساوي 0.71
+
+458
+00:38:33,670 --> 00:38:40,000
+تمام؟ اه، السؤال: أنا كنت أوضح الشغل اللي عرضته ليه؟
+
+459
+00:38:40,000 --> 00:38:42,020
+هي مع الـ X بيبقى مشهور حتى اللي إثنين ما بصوا اللي
+
+460
+00:38:42,020 --> 00:38:45,000
+.. صحيح صحيح صحيح، الـ point 6 برضه لإعتبار أنه
+
+461
+00:38:45,000 --> 00:38:48,600
+force يعني اللي بيحكي لك ممكن تمطر، بس بالنسبة أقل
+
+462
+00:38:48,600 --> 00:38:56,200
+بيحكي لي أنه إذا ما مطرتش اليوم، هذا الـ LN اللي هو
+
+463
+00:38:56,200 --> 00:39:02,140
+likelihood of necessity هو مؤشر على أنه لو ما حدثش
+
+464
+00:39:02,140 --> 00:39:06,210
+الـ event هذا، في حالة غياب الـ event، هل أقدر أستنتج
+
+465
+00:39:06,210 --> 00:39:13,490
+و بـ .. أستنتج نفس الـ situation وبأي نسبة؟ هذا أنه
+
+466
+00:39:13,490 --> 00:39:21,060
+إذا حدث، أقدر أستنتج بنسبة .. بقوة، هذه درجة قوة
+
+467
+00:39:21,060 --> 00:39:25,980
+الاعتقاد، الـ human expert بيعتقد إنه هذا مؤدي لهذا
+
+468
+00:39:25,980 --> 00:39:30,960
+بدرجة كبيرة، عشانها حاطط 2.5، بينما في نفس الوقت
+
+469
+00:39:30,960 --> 00:39:35,580
+بيعتقد إنه حتى لو ما حدثتش، برضه ممكن يحدث الـ event
+
+470
+00:39:35,580 --> 00:39:45,780
+ولكن هو اعتقاده ضعيف، 6 من 10. خلي بالك أنا في
+
+471
+00:39:45,780 --> 00:39:51,350
+هنا في الـ slide، فلتتها وهي إن هذه الـ S والـ M أنا
+
+472
+00:39:51,350 --> 00:39:55,430
+أستطيع أشتقهم من الـ statistics، لو عندنا statistics
+
+473
+00:39:58,860 --> 00:40:03,100
+لو عندنا statistics، نستطيع إنه نقول الـ human
+
+474
+00:40:03,100 --> 00:40:06,940
+expert يعطيك العافية تماماً، وأنا بقدر آخد الـ
+
+475
+00:40:06,940 --> 00:40:10,400
+likelihood values هذه بناءً على الـ statistics بس
+
+476
+00:40:10,400 --> 00:40:14,260
+إحنا ليش قلناها؟ لو ما فيش statistics، وغالباً مش
+
+477
+00:40:14,260 --> 00:40:17,200
+هيبقى فيه statistics. أنا ما بقدر أجيب statistics في
+
+478
+00:40:17,200 --> 00:40:20,720
+كل مجال بدي أعمل فيه expert system، اللي هي الـ
+
+479
+00:40:20,720 --> 00:40:24,900
+statistics حاضرة، وحاضرة لكل الـ events المحتملة، وكل
+
+480
+00:40:24,900 --> 00:40:29,550
+الـ hypothesis المحتملة، صح؟ hypothesis المحتملة، فأنا
+
+481
+00:40:29,550 --> 00:40:33,750
+بستعيض عن ذلك بالـ human expert اللي شغال في هذا
+
+482
+00:40:33,750 --> 00:40:37,150
+المجال الدقيق، وبقول له: اعطيني الـ values هذه، اعطيني
+
+483
+00:40:37,150 --> 00:40:40,850
+الـ rules، وحط لي لكل rule الـ likelihood values تبع
+
+484
+00:40:40,850 --> 00:40:49,450
+الـ necessity
+
+485
+00:40:49,450 --> 00:40:55,130
+و
+
+486
+00:40:55,130 --> 00:41:00,430
+الـ sufficiency. أو نكمل كمان خطوتين من المثال، وصلنا
+
+487
+00:41:00,430 --> 00:41:04,570
+إحنا لهناك. حلو، هذا الاستنتاج إن tomorrow is rain
+
+488
+00:41:04,570 --> 00:41:09,930
+متوقع بنسبة 71%. طيب، إيش رأيكوا إنه أنا الآن rule
+
+489
+00:41:09,930 --> 00:41:16,110
+رقم واحد، مش هي اللي لحالها، بقدر إيش أعملها firing
+
+490
+00:41:16,110 --> 00:41:22,790
+الـ expert system ممكن يعمل firing لمين؟ rule رقم
+
+491
+00:41:22,790 --> 00:41:27,430
+إثنين أيضاً. معين، rule رقم إثنين بتشترط الشرط تبعها
+
+492
+00:41:27,430 --> 00:41:36,310
+إن اليوم dry، اليوم dry، صح؟ أيوة. أنا
+
+493
+00:41:36,310 --> 00:41:41,870
+الآن برضه أنظر إلى dry هذا على إنه لم يتحقق، وأحسب
+
+494
+00:41:41,870 --> 00:41:49,810
+الاستنتاج هذا بناءً على الـ LN. لأ، أنا مش عندي rain
+
+495
+00:41:49,810 --> 00:41:54,460
+الـ event اللي عندي هو rain. لما يكون عكس الـ dry، إيش
+
+496
+00:41:54,460 --> 00:41:59,600
+معنى ذلك؟ إن dry لم يتحقق، يبقى بقدر أحسب الاستنتاج
+
+497
+00:41:59,600 --> 00:42:06,600
+هذا على أساس من الـ LN. إحنا إيش قلنا أصلاً؟ الـ LN إيش
+
+498
+00:42:06,600 --> 00:42:10,560
+وظيفته إنه إذا لم يتحقق الشرط هنا، فهو الرقم واحد.
+
+499
+00:42:10,560 --> 00:42:13,240
+كان متحقق مرتين، ما حسبناش على أساسه، حسبنا على أساس
+
+500
+00:42:13,240 --> 00:42:17,880
+الـ LS. الـ LS الآن هو الرقم إثنين. أنا بدي أشوف
+
+501
+00:42:17,880 --> 00:42:21,500
+الـ dry على إنه لم يتحقق لأنه غير موجود، وأحسبها
+
+502
+00:42:21,500 --> 00:42:25,320
+على أساسه. هذا هو اللي عامله هنا بالظبط، اللي هو جاب لك
+
+503
+00:42:25,320 --> 00:42:28,000
+إيه، إيش إن اليوم مطلوب؟ هو مفهوم إن اليوم مطلوب
+
+504
+00:42:28,000 --> 00:42:32,060
+فراح حسب الـ .. الـ odds على أساس إيش؟ أو .. أو ..
+
+505
+00:42:32,060 --> 00:42:35,220
+الـ odds دائماً هي حسب الـ .. الـ .. الـ .. الـ prior
+
+506
+00:42:35,220 --> 00:42:38,740
+odds. لما حسبها حسب الـ posterior odds، الـ posterior
+
+507
+00:42:38,740 --> 00:42:41,480
+odds حسبها على أساس الـ .. الـ .. الـ .. الـ .. اللي
+
+508
+00:42:41,480 --> 00:42:46,580
+هو إن اليوم مطلوب. اليوم مطلوب، هذا اليوم مطلوب، عكس
+
+509
+00:42:46,580 --> 00:42:52,490
+اليوم مطلوب، وطلعت الأربعية الآن حسب الـ .. إيش؟ من
+
+510
+00:42:52,490 --> 00:42:55,910
+الـ posterior odds، حسب الـ posterior probability
+
+511
+00:42:55,910 --> 00:42:59,130
+اللي هي الأربع على واحد زائد أربعة، و عشرة على واحد
+
+512
+00:42:59,130 --> 00:43:00,250
+زائد أربعة، وعشرة على واحد زائد أربعة، وأربعة وأربعة وأربعة
+
+513
+00:43:00,250 --> 00:43:01,270
+وأربعة وأربعة وأربعة وأربعة وأربعة وأربعة وأربعة
+
+514
+00:43:01,270 --> 00:43:02,370
+وأربعة وأربعة وأربعة وأربعة وأربعة وأربعة وأربعة
+
+515
+00:43:02,370 --> 00:43:02,410
+وأربعة وأربعة وأربعة وأربعة وأربعة وأربعة وأربعة
+
+516
+00:43:02,410 --> 00:43:04,070
+وأربعة وأربعة وأربعة وأربعة وأربعة وأربعة وأربعة
+
+517
+00:43:04,070 --> 00:43:05,790
+وأربعة وأربعة وأربعة وأربعة وأربعة وأربعة وأربعة
+
+518
+00:43:05,790 --> 00:43:18,750
+وأربعة وأربعة وأربعة وأربعة وأربعة وأربعة
+
+519
+00:43:18,750 --> 00:43:24,190
+ألو، أنا طلعت اليوم rain. تمام، بالنسبة معينة طلعت
+
+520
+00:43:24,190 --> 00:43:31,770
+طلعت طلعت طلعت طلعت طلعت طلعت طلعت
+
+521
+00:43:31,770 --> 00:43:33,650
+طلعت طلعت طلعت طلعت طلعت طلعت طلعت طلعت طلعت طلعت
+
+522
+00:43:33,650 --> 00:43:35,130
+طلعت طلعت طلعت طلعت طلعت طلعت طلعت طلعت طلعت طلعت
+
+523
+00:43:35,130 --> 00:43:37,750
+طلعت طلعت طلعت طلعت طلعت طلعت طلعت طلعت طلعت طلعت
+
+524
+00:43:37,750 --> 00:43:39,970
+طلعت طلعت طلعت طلعت طلعت طلعت طلعت طلعت طلعت طلعت
+
+525
+00:43:39,970 --> 00:43:41,830
+طلعت طلعت طلعت طلعت طلعت طلعت طلعت طلعت طلعت طلعت
+
+526
+00:43:42,530 --> 00:43:45,970
+هذا درجة طبعاً، بس هو كلامك صحيح الآن، لأن هي دي أنا
+
+527
+00:43:45,970 --> 00:43:48,590
+استنتاج نتج عن two rules، والـ two rules اللي هو
+
+528
+00:43:48,590 --> 00:43:56,030
+واحد عكس الثاني، صح؟ اه، فإحنا الآن في السؤال التالي
+
+529
+00:43:56,030 --> 00:43:59,390
+في الـ dialogue، بكمل الأسئلة وبسأل الـ user عنه
+
+530
+00:43:59,390 --> 00:44:04,610
+اللي هي rainfall، قداش الـ rainfall؟ مستوى الـ low ولا
+
+531
+00:44:04,610 --> 00:44:10,040
+كده ولا high ولا تمام؟ low. وبعدين هي كده، وبالتالي هذه
+
+532
+00:44:10,040 --> 00:44:13,700
+نفس الكلام اللي كنا فيه بالحالة الأولى، في حالة الـ
+
+533
+00:44:13,700 --> 00:44:17,260
+certainty factors. فهي عندي rain وهي عندي low
+
+534
+00:44:17,260 --> 00:44:20,160
+فاتحققت من الـ rule ثلاثة، وبناءً على الـ rule ثلاثة
+
+535
+00:44:20,160 --> 00:44:26,840
+الآن بدي أريد حساب، من أستنتج ضرائي لهذا الـ rule
+
+536
+00:44:26,840 --> 00:44:31,640
+ضرائي، بس بدي أريد حساب اللي هو probability تبع هذا
+
+537
+00:44:31,640 --> 00:44:37,880
+الاستنتاج، فبيطلع معاه بعد هيك إيش؟ 80%. فبكامِل إنه في
+
+538
+00:44:37,880 --> 00:44:43,320
+صار في اليوم rainfall، ولكنه ما انخفض، فرفع احتمالية
+
+539
+00:44:43,320 --> 00:44:49,100
+إنه بكره rain dry، ولكن برفع احتمالية إنه rain، لأن
+
+540
+00:44:49,100 --> 00:44:52,920
+هدول بيجمعوا، ما بيجمعوش، صح؟ لأن صار في عندي هذه
+
+541
+00:44:52,920 --> 00:44:55,720
+الكلام جاي على ثلاثة rules، وثلاثة rules لأن في
+
+542
+00:44:55,720 --> 00:45:00,120
+مقاييس مختلفة، مش إنه واحدة عكس الثانية. أنا بقدر
+
+543
+00:45:00,120 --> 00:45:04,180
+أسيبكم تكملوا أنتم لحالكم على الـ example هذا، و
+
+544
+00:45:04,180 --> 00:45:09,720
+تشوفوا كيف تحسوا فيها، بتستمتعوا. والمحاضرة الجاية
+
+545
+00:45:09,720 --> 00:45:13,400
+إن شاء الله بكون محاضِر لكم exercise، exercise
+
+546
+00:45:13,400 --> 00:45:17,420
+تتحلوا لوحدكم طبعاً. فإحنا عملياً من الآن بنكون خلصنا
+
+547
+00:45:17,420 --> 00:45:25,000
+الـ slides هذه كلها؟ أي نعم، كلها، وبنكون وقفنا
+
+548
+00:45:25,000 --> 00:45:32,760
+في الـ .. في الـ sequence تبعنا، عند هذا، هذا الـ band
+
+549
+00:45:32,760 --> 00:45:36,380
+أنا زي ما قُلت، هذا الـ band أنا هأترككم أنتم
+
+550
+00:45:36,380 --> 00:45:41,680
+مراجعة عامة لكلام اللي أخذتو في الـ probability، و
+
+551
+00:45:41,680 --> 00:45:45,680
+نبتدئ إحنا بيكون، ووقفنا هنا. المحمد جايب بـ ..
+
+552
+00:45:45,680 --> 00:45:49,860
+بيعطيكم exercise، وبيحكي في النقطتين الأخيرتين.
+
diff --git a/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/f6_eLzRXoWg_postprocess.srt b/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/f6_eLzRXoWg_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..fc6672308633a3c0c142351c505e54d8471accc6
--- /dev/null
+++ b/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/f6_eLzRXoWg_postprocess.srt
@@ -0,0 +1,1776 @@
+1
+00:00:20,700 --> 00:00:22,800
+ماشى بسم الله الرحمن الرحيم المحاضرة هاد ان شاء
+
+2
+00:00:22,800 --> 00:00:27,220
+الله احنا المفروض ننتقل لموضوع مختلف تماما ومختلف
+
+3
+00:00:27,220 --> 00:00:31,800
+عن ال .. اللي هو ال problem solving by search بس
+
+4
+00:00:31,800 --> 00:00:38,300
+بدنا نجف عن نقطتين صغار تكملة او متابعة لاخر اشي
+
+5
+00:00:38,300 --> 00:00:41,080
+حكيناه في المحاضرة الماضية المحاضرة الماضية احنا
+
+6
+00:00:41,080 --> 00:00:43,620
+كنا بنحكي عن ال alpha beta pruning وكان في انا
+
+7
+00:00:43,620 --> 00:00:47,630
+example اللي هو هذا المثالهذا المثال الـ tree هذه
+
+8
+00:00:47,630 --> 00:00:51,070
+و كده ماشينا في الـ pruning تبعها و بدأنا من
+
+9
+00:00:51,070 --> 00:00:54,690
+الشمال لليمين كانت انا two rules أساسية بنطلع
+
+10
+00:00:54,690 --> 00:00:58,370
+عليها علشان نعمل الـ pruning اللي هو انه ال .. اذا
+
+11
+00:00:58,370 --> 00:01:02,790
+انا على main level تمام؟ و ال node اللي انا واقف
+
+12
+00:01:02,790 --> 00:01:06,710
+عليها ال beta تبعها ال beta تبعها لمين اجا؟ اجا
+
+13
+00:01:06,710 --> 00:01:11,070
+بعد استكشاف ال children تمام؟ و بيضلوا beta بيضلوا
+
+14
+00:01:11,070 --> 00:01:14,190
+محتمل الى ان نستنفذ كل ال children
+
+15
+00:01:16,490 --> 00:01:21,610
+بس طالما ان هو لسه ماتبعدش فهو beta إذا ال beta
+
+16
+00:01:21,610 --> 00:01:26,590
+هذا كان أقل من أو يساوي ال alpha تبع ال parent تبع
+
+17
+00:01:26,590 --> 00:01:32,250
+ال node نقدر نوقف مافيش داعي نستمر لأنه عالفاضي و
+
+18
+00:01:32,250 --> 00:01:36,130
+الأكس من ذلك في حالة إذا كنا على ال max level إذا
+
+19
+00:01:36,130 --> 00:01:40,210
+كنا على ال max level بدنا نطلع إذا ال alpha تبعت
+
+20
+00:01:40,210 --> 00:01:45,350
+ال node أكبر من أو أقل من ال beta تبعت من ال
+
+21
+00:01:45,350 --> 00:01:49,240
+parentبرضه بننقل ماشي اللي اشتبه عليكم المحاضرة
+
+22
+00:01:49,240 --> 00:01:52,680
+اللي فاتت انه لو انت بصيت Alpha أكبر من أو يساوي
+
+23
+00:01:52,680 --> 00:01:56,700
+Beta هتطلع ماهي نفسها برضه Alpha أكبر من أو يساوي
+
+24
+00:01:56,700 --> 00:02:00,300
+Beta لو أخدتها انت فاشتبه عليكم ان هي نفس ال rule
+
+25
+00:02:00,300 --> 00:02:03,420
+بس واقعي الأمر انه مش نفس ال rule لأن هنا احنا
+
+26
+00:02:03,420 --> 00:02:06,120
+بنحكي عن Alpha تبع ال parent بينما هنا Alpha تبع
+
+27
+00:02:06,120 --> 00:02:09,660
+ال node وهنا بنحكي عن Beta تبع ال parent بينما هنا
+
+28
+00:02:09,660 --> 00:02:16,460
+Beta تبع ال nodeنقطة استحقت ان احنا نراجحها بخصوص
+
+29
+00:02:16,460 --> 00:02:18,860
+محاضرة الفادات النقطة التانية اللي هي ان احنا لو
+
+30
+00:02:18,860 --> 00:02:24,260
+احنا بنعمل programming في شغلتين صغار يعني بدنا
+
+31
+00:02:24,260 --> 00:02:29,160
+نرجعهم اول اشي ان هنا ال B ال B لما احنا عملنا
+
+32
+00:02:29,160 --> 00:02:31,660
+programming لمحاضرة الفادات كملنا بعد ما شوفنا
+
+33
+00:02:31,660 --> 00:02:35,900
+الخمسة كملنا معاهم هذا الكلام مش مفروض ليش لأنه
+
+34
+00:02:35,900 --> 00:02:40,520
+كانت ال alpha تابعة البعد ما ال B شافت ال child
+
+35
+00:02:40,520 --> 00:02:44,080
+الأولاني ويقوله خمسة already هذه خمسة أكبر من
+
+36
+00:02:44,080 --> 00:02:48,360
+الألفة
+
+37
+00:02:48,360 --> 00:02:51,440
+أكبر من ال beta تبع ال parent يبقى المفروض أن أنا
+
+38
+00:02:51,440 --> 00:02:56,780
+أوقف هنا لم أوقف ناش صح فهذا لازم يصحح بالظبط
+
+39
+00:02:56,780 --> 00:03:01,620
+فالان احنا نجرب ال B شوف ال child الأول و تكتشف أن
+
+40
+00:03:01,620 --> 00:03:05,380
+ال value تبعه خمسة في الألفة تبعها ليش الألفة
+
+41
+00:03:05,380 --> 00:03:09,020
+تبعها لأن أنا في level maxالألف ده بقتها ساعة خمسة
+
+42
+00:03:09,020 --> 00:03:13,520
+خمسة أكبر من تلاتة يبقى إيش لازم توقف ال search
+
+43
+00:03:13,520 --> 00:03:17,280
+لازم توقف ال search وما تتطلعش على ال child هذا
+
+44
+00:03:17,280 --> 00:03:20,640
+أوي إذا حتى في children أخر منا هذا النقطة الأولى
+
+45
+00:03:20,640 --> 00:03:23,260
+اللي هي أن ال proning لازم نحصل ال proning هنا
+
+46
+00:03:23,260 --> 00:03:27,540
+النقطة التانية أنه احنا في المرة الفاترة اعتبرنا
+
+47
+00:03:27,540 --> 00:03:31,500
+أن ال zero ماهواش lowest بمعنى أنه في احتمال يكون
+
+48
+00:03:31,500 --> 00:03:35,200
+في أقل من zero لذلك استمرنا استمرنا ببحث عن level
+
+49
+00:03:35,200 --> 00:03:41,320
+منالـ Min لم يعد مستمر، شفت الـ Zero لكن استمرت
+
+50
+00:03:41,320 --> 00:03:45,300
+لأنه قد يكون فيه أقل من الـ Zero إذا مُعطى إليك في
+
+51
+00:03:45,300 --> 00:03:51,020
+المثل أن الـ Zero هو ال minimum possible value
+
+52
+00:03:51,020 --> 00:03:56,290
+يبقى بتوقف، خلاص، مافيش إذا شُفت Child0 وكانت هنا
+
+53
+00:03:56,290 --> 00:04:00,810
+beta 0 مافي داعي لأنه مافي ممكن اتوقع اقل من 0 اذا
+
+54
+00:04:00,810 --> 00:04:04,910
+هذا الكلام موضح اليك في المسألة فبتحط pruning هنا
+
+55
+00:04:04,910 --> 00:04:09,930
+صح النقطة هذه سوناها مظبوط زي هيك فمافيش اي مشكلة
+
+56
+00:04:09,930 --> 00:04:15,150
+احنا حكينا عن نقطتين النقطة الأولى اللي هي rules
+
+57
+00:04:15,150 --> 00:04:22,850
+النقطة التانية اللي هيقالية ال proning اللي سوناها
+
+58
+00:04:22,850 --> 00:04:26,210
+النقطة التالتة ان احيانا ممكن تجيلك مسألة ينطلب
+
+59
+00:04:26,210 --> 00:04:31,910
+فيها منك تعمل right to left proning احنا كنا
+
+60
+00:04:31,910 --> 00:04:35,990
+شغالين على الدوام left to right proning لو انطلب
+
+61
+00:04:35,990 --> 00:04:39,210
+منك right to left نفس الجثة مااختلفتش بس هيطلع
+
+62
+00:04:39,210 --> 00:04:43,970
+جواب مختلف يعني لما انا اعمل Q&A 3 و اعمل left to
+
+63
+00:04:43,970 --> 00:04:50,640
+right proning اه هيطلعال proning نفس لو انا بدي
+
+64
+00:04:50,640 --> 00:04:57,740
+اعمل right to left حتما لانه .. ليش؟ لأنه انا بشوف
+
+65
+00:04:57,740 --> 00:05:00,500
+notes غير عن اللي هشوفها .. هشوف notes من الأول و
+
+66
+00:05:00,500 --> 00:05:03,580
+غير عن اللي هشوفها من .. لو جيت من الاتجاه التاني،
+
+67
+00:05:03,580 --> 00:05:07,860
+مظبوط؟ فال .. هذا ف .. هذا بس مطلة تالتة حابيت أنا
+
+68
+00:05:07,860 --> 00:05:10,580
+و هقلها اللي .. اللي .. اللي ممكن المسألة اللي
+
+69
+00:05:10,580 --> 00:05:13,860
+انطلب فيك .. انطلب فيها منك انك تعمل ال right to
+
+70
+00:05:13,860 --> 00:05:17,220
+left او يطلبك شغلتين left to right و right to left
+
+71
+00:05:18,080 --> 00:05:23,100
+مش مشكلة نفس القالية طيب هيك احنا بنكون خلصنا ايه
+
+72
+00:05:23,100 --> 00:05:26,760
+اللي بدنا نذكره عن المحاضرة .. التعليق على
+
+73
+00:05:26,760 --> 00:05:29,940
+المحاضرة اللي فاتت و بدنا نبدأ الآن في اللي هو
+
+74
+00:05:29,940 --> 00:05:32,840
+الموضوع الجديد .. الموضوع الجديد و من الكتاب
+
+75
+00:05:32,840 --> 00:05:36,780
+التاني الكتاب التاني اللي هو عندك هنا على ال drop
+
+76
+00:05:36,780 --> 00:05:42,240
+box في ال student folder في بداخله موجود في two
+
+77
+00:05:42,240 --> 00:05:46,060
+sub folders واحدة من الكتابينالكتاب اللى احنا بدنا
+
+78
+00:05:46,060 --> 00:05:49,720
+نشتغل باله اللى هو ال guide to intelligent systems
+
+79
+00:05:49,720 --> 00:05:53,880
+فى بداخله sub folder للسلايدات و فى بداخله pdf
+
+80
+00:05:53,880 --> 00:05:58,300
+file للكتاب نفسه ماشي انا بدى اعرض ال table of
+
+81
+00:05:58,300 --> 00:06:03,340
+contents تبع الكتاب الكتاب في حوالى 14 chapter
+
+82
+00:06:03,340 --> 00:06:06,960
+احنا هنبدأ من ال chapter التانى يتكلم عن google
+
+83
+00:06:06,960 --> 00:06:10,400
+based expert systems احنا الموضوع اللى دي عمليا هو
+
+84
+00:06:10,400 --> 00:06:11,660
+عن ال expert systems
+
+85
+00:06:16,200 --> 00:06:19,800
+و نوع محدد من ال expert systems اللي هو rule based
+
+86
+00:06:30,920 --> 00:06:33,740
+مشي هنطلع في الأول إيش يعني rules و بعدين إيش يعني
+
+87
+00:06:33,740 --> 00:06:35,960
+rule basics بال system و إيش هي ال structure تبع
+
+88
+00:06:35,960 --> 00:06:39,460
+ال rule basics بال system يعني تقريبا هنغطي كافة
+
+89
+00:06:39,460 --> 00:06:42,900
+اللي هو ال succession تبع هذا ال chapter و نكمل
+
+90
+00:06:42,900 --> 00:06:46,160
+بعد هيك الشباتر التاني بس مش هناخد ال 14 chapter
+
+91
+00:06:46,160 --> 00:06:50,910
+كلهم غالبا هنقصر بس لعنده عشرات أو أحد عشرأحنا
+
+92
+00:06:50,910 --> 00:06:53,590
+موضوعنا اليوم ان شاء الله عن ال rule based express
+
+93
+00:06:53,590 --> 00:07:00,090
+system ففي عندنا سلايدات اللي هم اصلا مع الكتاب
+
+94
+00:07:00,090 --> 00:07:04,170
+اللي هو عندي هذا ال slide هذي okay rule based
+
+95
+00:07:04,170 --> 00:07:09,290
+express system تمام
+
+96
+00:07:09,290 --> 00:07:13,110
+فاحنا هنتقلع عليها بس مش بنفس الترتيب السلايدات
+
+97
+00:07:13,110 --> 00:07:19,730
+اللي هم مرتبين هنا بدي أخدهم بترتيب مختلف شويةيعني
+
+98
+00:07:19,730 --> 00:07:29,390
+احنا بيكتب السيكاشة اللي هنمشي عليها في هذا الشرطر
+
+99
+00:07:29,390 --> 00:07:39,330
+كأننا عملين لان هبدأ في ال structure of
+
+100
+00:07:39,330 --> 00:07:46,990
+اللي هو rule based expert systems وبعدين نطلع على
+
+101
+00:08:01,590 --> 00:08:06,750
+الانفرانس ميكانيزم و بعدين هنطلع على conflict
+
+102
+00:08:06,750 --> 00:08:07,250
+resolution
+
+103
+00:08:18,450 --> 00:08:22,550
+بالتالي، هذا الكلام يجعلنا أننا في الـ slides نذهب
+
+104
+00:08:22,550 --> 00:08:30,410
+على
+
+105
+00:08:30,410 --> 00:08:32,810
+طول على النقطة هذه الـ Structure أو الـ Rule
+
+106
+00:08:32,810 --> 00:08:37,770
+Basics في الـ System ثم هنا، بعدها الـ Conflict
+
+107
+00:08:37,770 --> 00:08:42,910
+Resolution النقاط التانيبنرجعلها بعد .. بعد ما
+
+108
+00:08:42,910 --> 00:08:46,650
+نخطف فكرة عن قليلة عمل لل Express System بنطلع على
+
+109
+00:08:46,650 --> 00:08:51,670
+ال main players in the development of the team و
+
+110
+00:08:51,670 --> 00:08:54,950
+ايضا كذا كهال characteristics of Express System ال
+
+111
+00:08:54,950 --> 00:08:57,790
+introduction هتكون احنا غطينا محتوىها و احنا
+
+112
+00:08:57,790 --> 00:09:01,660
+بنتكلم يعنى تمام؟ فاحنا الان امامالحاجة اسمها ال
+
+113
+00:09:01,660 --> 00:09:04,080
+express system ال express system يعني اللي هو
+
+114
+00:09:04,080 --> 00:09:08,000
+النظام الخبير النظام الخبير هذا عبارة عن نوع من
+
+115
+00:09:08,000 --> 00:09:11,920
+التطبيقات اللي بيستخدم في الحياة العملية غالبا في
+
+116
+00:09:11,920 --> 00:09:15,820
+ال business ولا في الطب ولا في ال maintenance
+
+117
+00:09:15,820 --> 00:09:19,520
+والصيانة والتشخيص وكده اللي مقصود ب express system
+
+118
+00:09:19,520 --> 00:09:24,780
+أيش؟ مقصود بيه هو عبارة عن system يحل محل كلمة يحل
+
+119
+00:09:24,780 --> 00:09:29,830
+محل حُط تحتها خطلأنه مافي system هيقدر يحل محال ال
+
+120
+00:09:29,830 --> 00:09:32,990
+human expert ايش عن ال human expert خبير البشري
+
+121
+00:09:32,990 --> 00:09:36,010
+ايش عن الخبير البشري يعني انسان مختص في مجال معين
+
+122
+00:09:36,010 --> 00:09:40,590
+الطبيب مختص في مجاله الفن الصيانة مختص في مجال
+
+123
+00:09:40,590 --> 00:09:44,850
+عمله الموظف اللي في البنك اللي بيقرر جديش يعطي
+
+124
+00:09:44,850 --> 00:09:48,210
+القروض و اللي ماهي دلوقتي هذا مختص في مجاله فاحنا
+
+125
+00:09:48,210 --> 00:09:55,070
+إذا كان قدرنا نعمل system اللي يحاكيهذا الدور اللي
+
+126
+00:09:55,070 --> 00:09:59,450
+هو عملية اتخاذ القرار في المجالات المختلفة هذه
+
+127
+00:09:59,450 --> 00:10:04,530
+فبسميه Express System الإشكالية الأساسية في عمل
+
+128
+00:10:04,530 --> 00:10:09,290
+هذا ال system انه العلم والمعرفة والتخصص اللي
+
+129
+00:10:09,290 --> 00:10:14,630
+بيفهمه هذا الشخص كيف انعبر عنهم بشكل مبرمج يعني ثم
+
+130
+00:10:14,630 --> 00:10:18,590
+بعد ذلك كيف نعمل عملية التحليل تحليل المعرفة هذه
+
+131
+00:10:18,590 --> 00:10:23,040
+من أجل اتخاذ القرار لأن كل العمليةعملية اتخاذ قرار
+
+132
+00:10:23,040 --> 00:10:27,000
+يعني ال express system يتعرض عليه حالة بموافقات
+
+133
+00:10:27,000 --> 00:10:31,960
+معينة و هو يتخذ قرار انه هدى نتعامل معاه هيك او
+
+134
+00:10:31,960 --> 00:10:36,760
+نتعامل معاه هيك فالقالية
+
+135
+00:10:36,760 --> 00:10:39,920
+من قليات بناء ال express systems اللي هي انه احنا
+
+136
+00:10:39,920 --> 00:10:44,940
+نعبر عن المعرفة على شكل rules ال rule يعني if then
+
+137
+00:10:44,940 --> 00:10:49,360
+مظبوط فاحنا الآن لو طلعنا على السريع على أنماط من
+
+138
+00:10:49,360 --> 00:10:54,020
+ال rulesزي هنا مثلا مش عارف الشاشة واضحة ولا لا
+
+139
+00:10:54,020 --> 00:11:02,900
+خلّيني أكبر ال .. و أعمل full screen تمام؟ control
+
+140
+00:11:02,900 --> 00:11:10,440
+L اه control L okay هذه عبارة عنقول if the traffic
+
+141
+00:11:10,440 --> 00:11:15,540
+light is green يبجي ال action انه to go if the
+
+142
+00:11:15,540 --> 00:11:18,720
+traffic light is red then the action is stop تمام؟
+
+143
+00:11:18,910 --> 00:11:21,690
+أحيانا ال words بتبقى معقدة بمعنى أنه ممكن يبقى
+
+144
+00:11:21,690 --> 00:11:26,410
+فيها أكتر من condition if كده and كده and مش عارف
+
+145
+00:11:26,410 --> 00:11:31,130
+شوف بعدها then أجزاء تبع الشرط مش عارف إن عندي if
+
+146
+00:11:31,130 --> 00:11:35,590
+then اللي قبل then هذا الشرط وthen ليش ال
+
+147
+00:11:35,590 --> 00:11:38,310
+conclusion أقعد أقول أحنا ممكن نسميهم antecedence
+
+148
+00:11:38,310 --> 00:11:42,850
+antecedence اللي هو أجزاء الشرط سواء كان جزء واحد
+
+149
+00:11:42,850 --> 00:11:46,630
+أو multiple وال conclusion نسميها consequence
+
+150
+00:11:50,900 --> 00:11:54,560
+consequence الان فى أنواع من ال rules فى rules
+
+151
+00:11:54,560 --> 00:11:57,320
+بتعبر عن relation فى rules بتعبر عن recommendation
+
+152
+00:11:57,320 --> 00:12:00,660
+فى rules بتعبر عن directive هنرجعلهم هذا الأمور بس
+
+153
+00:12:00,660 --> 00:12:05,060
+أنا بمعنى بإن أفهم البنية تبع ال express system
+
+154
+00:12:05,060 --> 00:12:10,260
+اللى ال rules لسه جزء من أجزاها فالبنية أو ال
+
+155
+00:12:10,260 --> 00:12:10,840
+structure
+
+156
+00:12:14,090 --> 00:12:17,710
+أنا بانتقل إلى ال structure هاي ال structure of a
+
+157
+00:12:17,710 --> 00:12:21,970
+rule based system جاية بال .. بالتبسيط هذا يعني
+
+158
+00:12:21,970 --> 00:12:27,350
+تبسيط لل production system يعني هنا في عندي memory
+
+159
+00:12:27,350 --> 00:12:31,750
+ال memory هذه هي اللي بتتخزن ال knowledge المعرفة
+
+160
+00:12:31,750 --> 00:12:36,950
+ال knowledge تتخزن بصيغة ال rules يعني احنا لما
+
+161
+00:12:36,950 --> 00:12:42,350
+بنقول if a traffic light is red then stopهذه معرفة
+
+162
+00:12:42,350 --> 00:12:45,170
+احنا بنعلمها للولادة الصغيرة و بصرا احنا بعد هيك
+
+163
+00:12:45,170 --> 00:12:50,010
+عارفينها تلقائيا بس احنا يعني انه .. انه اذا الضوء
+
+164
+00:12:50,010 --> 00:12:55,510
+أحمر ايجا فهذه عبرنا عنها على شكل rule و ده كل ال
+
+165
+00:12:55,510 --> 00:13:00,870
+knowledge و الخبرة تبع ال human expert بانصيغة على
+
+166
+00:13:00,870 --> 00:13:04,310
+شكل rules ف .. و بنحطها في ليش؟ في ال long term
+
+167
+00:13:04,310 --> 00:13:08,790
+memoryهذا أول مكوّن من مكونات ال Express System
+
+168
+00:13:08,790 --> 00:13:13,390
+إضافة إلى ذلك يجب أن يكون لدي موري تانية Short
+
+169
+00:13:13,390 --> 00:13:17,970
+Term Memory اللي هي معطيات الحالة اللي سيستم
+
+170
+00:13:17,970 --> 00:13:23,290
+يتعامل معها سيستم يقول فلان لفلان حالته عنده حالة
+
+171
+00:13:23,290 --> 00:13:28,970
+مرضية و أعراضه كذا و كذا و كذا هذه المعطيات تنحط
+
+172
+00:13:28,970 --> 00:13:34,240
+في Short Term Memory بينما العلمالتشخيص والأمراض
+
+173
+00:13:34,240 --> 00:13:39,080
+وكيف تكون موجودة محبرة عنها في rules وين في ال
+
+174
+00:13:39,080 --> 00:13:44,620
+long term memory العنصر
+
+175
+00:13:44,620 --> 00:13:48,660
+الأساسي من عناصر ال expert system اللي هو ال
+
+176
+00:13:48,660 --> 00:13:51,240
+reasoning أو ال inference engine
+
+177
+00:13:56,270 --> 00:13:59,190
+ماشي يعني inference؟ inference جاي من to infer
+
+178
+00:13:59,190 --> 00:14:04,150
+infer يعني استنبط، نستنبط احنا استنتاج بناء على
+
+179
+00:14:04,150 --> 00:14:07,670
+المواضيع أو بناء على الحقائق ال inference مش
+
+180
+00:14:07,670 --> 00:14:12,790
+interference inference to infer ماشي معناته ان
+
+181
+00:14:12,790 --> 00:14:17,880
+احنا نستنبط conclusions بناء على المواضيعوهذه هي
+
+182
+00:14:17,880 --> 00:14:21,680
+ال engine أو ال component أساسي لل system Express
+
+183
+00:14:21,680 --> 00:14:28,900
+نرى كيف تعمل الفكرة ال inference engine ببساطة
+
+184
+00:14:28,900 --> 00:14:33,440
+شديدة بعد ذلك ال inference engine هو اللي يطلع ال
+
+185
+00:14:33,440 --> 00:14:38,260
+conclusion يعني هو بعتمد على ال long term memory
+
+186
+00:14:38,260 --> 00:14:41,800
+مع ال facts تبع ال short term memory عشان يعطيني
+
+187
+00:14:41,800 --> 00:14:44,120
+ال conclusion اللي أنا ببحث عنها
+
+188
+00:14:47,790 --> 00:14:53,180
+تمام هذه كانت ايش يعني تبسيط شديدممكن بضبط ندخل
+
+189
+00:14:53,180 --> 00:14:57,400
+عناصر أخرى على ال structure اللي هي انه ممكن انا
+
+190
+00:14:57,400 --> 00:15:00,940
+اضيف حد اسمه user interface معناه ان هذا ال system
+
+191
+00:15:00,940 --> 00:15:04,120
+هو في نهاية الأمر is an application software
+
+192
+00:15:04,120 --> 00:15:07,000
+application صح؟ و ال software application هذا بده
+
+193
+00:15:07,000 --> 00:15:11,280
+interface عشان انا ك user اتعامل معها ال interface
+
+194
+00:15:11,280 --> 00:15:14,980
+يعني قد تكون graphical GUI يعني او قد تكون
+
+195
+00:15:14,980 --> 00:15:20,030
+dialogue based يعني كأني بتحاور معاهمواحد على تشات
+
+196
+00:15:20,030 --> 00:15:22,970
+و لا على كده بيسألني أسئلة وبتجاوب بيسألني وبتجاوب
+
+197
+00:15:22,970 --> 00:15:27,090
+بيسألني وبتجاوب إلى أن بعد هيك .. اه يعني افترض
+
+198
+00:15:27,090 --> 00:15:30,890
+انه مريض وعنده .. وبده .. وبيبحث عن التشكيس الصحيح
+
+199
+00:15:30,890 --> 00:15:34,790
+لحالته فال system بيجي بيقوله اول سؤال مثلا ايش
+
+200
+00:15:34,790 --> 00:15:38,190
+بتشكي فبقوله باشكي من كده بقوله ايش كمان باشكي من
+
+201
+00:15:38,190 --> 00:15:41,590
+كده وكده هذه الأسئلة اللي هو بيسأله فيها بناء على
+
+202
+00:15:41,590 --> 00:15:47,920
+ال inference engine شو قاعدبيحلل في الموضوع فكل ما
+
+203
+00:15:47,920 --> 00:15:51,720
+يحتاج قطرة معلومة بيسأل ال user عنه هنا بتكون ال
+
+204
+00:15:51,720 --> 00:15:54,640
+interface او ال interaction ما بين ال system و ما
+
+205
+00:15:54,640 --> 00:15:57,540
+بين ال user عبارة عن dialogue based ممكن زي ما قلت
+
+206
+00:15:57,540 --> 00:16:02,040
+انا ال cash GUI form بتعب فيها كل المعطلات اللي
+
+207
+00:16:02,040 --> 00:16:05,470
+عندك و تضغط زر و هو بيعطيك cashبيعطيك ال
+
+208
+00:16:05,470 --> 00:16:08,650
+conclusion او ال decision مرة واحدة او بلاش
+
+209
+00:16:08,650 --> 00:16:11,870
+decision واحدة ممكن يعطيك alternatives ويقولك افضل
+
+210
+00:16:11,870 --> 00:16:14,830
+اشي كده اللي بعده كده اللي بعده كده تمام بدائل
+
+211
+00:16:14,830 --> 00:16:18,410
+يعني من ال conclusions فهذا واضح ليش ان احنا ممكن
+
+212
+00:16:18,410 --> 00:16:22,010
+نحتاج user interface هذا شي طبيعي جدا ممكن ايضا
+
+213
+00:16:22,010 --> 00:16:25,030
+كمان نحتاج ال explanation facility جزئية من ال
+
+214
+00:16:25,030 --> 00:16:30,810
+system اللي ال user اذا احتاج او طلب انه okay انت
+
+215
+00:16:31,490 --> 00:16:36,110
+عطيتني ال conclusion طيب فسرلي كيف وصلت لها ال
+
+216
+00:16:36,110 --> 00:16:41,150
+user يطلب من ال system تفسير كيف هو وصل إلى ان هذا
+
+217
+00:16:41,150 --> 00:16:45,130
+ال decision هو الأنسب او هذا قرار هو الأنسب فلازم
+
+218
+00:16:45,130 --> 00:16:52,760
+يبدأ في module جزئية من ال system اللي تتسجلخطوات
+
+219
+00:16:52,760 --> 00:16:58,140
+ال inference كيف تمت علشان لما يطلب ال user يطلب
+
+220
+00:16:58,140 --> 00:17:01,460
+explanation هذا ال explanation facility تعرضله
+
+221
+00:17:01,460 --> 00:17:05,680
+التسلسل المنطقي لكيف تم التوصل الى ال conclusion
+
+222
+00:17:05,680 --> 00:17:09,560
+واضح ايش يعني explanation facility و facilities
+
+223
+00:17:09,560 --> 00:17:18,460
+تمام تمام فهذه هي ال .. بص .. ممكن بقول كمان احنا
+
+224
+00:17:18,460 --> 00:17:25,210
+ايشممكن كمان انمسى في ال structure حيث انه هنا ال
+
+225
+00:17:25,210 --> 00:17:29,110
+interface نجسمها إلى جسمين نقول user interface
+
+226
+00:17:29,110 --> 00:17:34,150
+ونقول developer interface ايش هتفرج ال developer
+
+227
+00:17:34,150 --> 00:17:40,630
+interface عن اختصاصك اكتر اختصاصا او اقل اختصاصا
+
+228
+00:17:40,630 --> 00:17:44,050
+هذا اسمه user interface ال user يعني ال end user
+
+229
+00:17:44,050 --> 00:17:48,370
+الشخص المستفيد من قدرات هذا ال systemبس ال
+
+230
+00:17:48,370 --> 00:17:52,290
+developer هنا هو عبارة عن الشخص اللي بيساهم في
+
+231
+00:17:52,290 --> 00:17:56,670
+بناء ال systemبس هنا .. ايوة ال developer
+
+232
+00:17:56,670 --> 00:18:00,850
+interface هنا يقصد بيها ال knowledge engineer اللي
+
+233
+00:18:00,850 --> 00:18:05,830
+بيحط ال rules و بيعدل عليها لأن ال system مقدرش
+
+234
+00:18:05,830 --> 00:18:09,310
+نتوقع انه يغلق على مجموعة من ال rules اللي انحطت
+
+235
+00:18:09,310 --> 00:18:12,590
+فيه من البداية و خلاص لأ لازم يصير فيه نوع من ال
+
+236
+00:18:12,590 --> 00:18:16,130
+learning او ال development على ال knowledge تبعته
+
+237
+00:18:16,130 --> 00:18:20,790
+فبيجي human expert او بيجي knowledge engineer
+
+238
+00:18:20,790 --> 00:18:27,090
+بيغذي ال system ب newالحقائق عن حالته الـ facts هي
+
+239
+00:18:27,090 --> 00:18:33,110
+الuser اللي بيعطي الحقائق عن حالته ال developer ال
+
+240
+00:18:33,110 --> 00:18:35,710
+knowledge engineer و ال expert بيستخدموا ال
+
+241
+00:18:35,710 --> 00:18:41,600
+developer interface علشانيغذي الـ system بـ more
+
+242
+00:18:41,600 --> 00:18:44,760
+knowledge كذلك هذا الـ system يمكن يأخذ more
+
+243
+00:18:44,760 --> 00:18:48,580
+knowledge و more data من other sources غير هذوله
+
+244
+00:18:48,580 --> 00:18:52,740
+يعني هو يبقى مربوط بشكل أو باخر مع other databases
+
+245
+00:18:52,740 --> 00:18:57,140
+يعمل نوع من collection لـ knowledge تلقائيا من
+
+246
+00:18:57,140 --> 00:19:02,620
+نفسه يعني ممكن يتعمل فيه آليات لجمع المعلومات بشكل
+
+247
+00:19:02,620 --> 00:19:08,030
+أو باخر يجيبها هو من مصادر خارجيةأحنا الآن تدرجنا
+
+248
+00:19:08,030 --> 00:19:15,690
+في فهم ال structure تبع ال
+
+249
+00:19:15,690 --> 00:19:20,990
+express system دلنا
+
+250
+00:19:20,990 --> 00:19:25,870
+الآن ندخل على ال core component تبع ال express
+
+251
+00:19:25,870 --> 00:19:28,610
+system اللي هو ال inference engine اللي هو بيقدّي
+
+252
+00:19:28,610 --> 00:19:33,130
+الشغل الأساسي اللي هو بيستنقط بيحلل المعطيات وال
+
+253
+00:19:33,130 --> 00:19:37,920
+knowledge عشانيخرج بـ Conclusion اللي هو ال
+
+254
+00:19:37,920 --> 00:19:42,320
+inference engine inference engine بيشتغل بقالية
+
+255
+00:19:42,320 --> 00:19:47,460
+اسمها forward chaining و أحيانا ممكن backward بس
+
+256
+00:19:47,460 --> 00:19:51,600
+نفهم ال forward تتضح إيش يعني ال backward بسيطة
+
+257
+00:19:51,600 --> 00:19:56,660
+جدا قاليته بسيطة جدا قالية عمل ال inference engine
+
+258
+00:19:56,660 --> 00:20:01,700
+ال inference engine بسيطة لأنها عبارة عن cycles
+
+259
+00:20:02,650 --> 00:20:08,990
+دورات نفسها هي هي بتتكرر عند ال database ال
+
+260
+00:20:08,990 --> 00:20:18,490
+database فيها facts تمام هذه short term memory وفي
+
+261
+00:20:18,490 --> 00:20:22,810
+عنده knowledge base اللي هي long term memory هذه
+
+262
+00:20:22,810 --> 00:20:28,730
+فيها facts قام ال user بتقديتها وهذه فيها rules
+
+263
+00:20:28,730 --> 00:20:31,230
+قام ال expert أو knowledge engineer
+
+264
+00:20:34,810 --> 00:20:39,690
+بهدف بتغييرته ببساطة شديدة هذه انتي انا هنا ال
+
+265
+00:20:39,690 --> 00:20:44,370
+rule ال rule فيها antecedent اللي هو ال condition
+
+266
+00:20:44,370 --> 00:20:49,610
+وفيها conclusion وظيفة
+
+267
+00:20:49,610 --> 00:20:53,430
+ال inference engine في كل cycle يبحث في ال memory
+
+268
+00:20:53,430 --> 00:20:57,630
+اللي هو شرط ال memory في ال database عن اي fact
+
+269
+00:20:57,630 --> 00:21:05,010
+يمكن انه يتحقق اي شرط من الشروطإذا تبقى تبقى ال
+
+270
+00:21:05,010 --> 00:21:08,670
+rules إذا فيه rule الشرط تبقى هتتحقق إيش هتتحقق
+
+271
+00:21:08,670 --> 00:21:15,430
+يعني في fact موجودة بتبطيه يبقى أنا برضه أستدج إنه
+
+272
+00:21:15,430 --> 00:21:22,050
+ال conclusion تبعته أصبحت fact ولا لأ يعني أنا أنا
+
+273
+00:21:22,050 --> 00:21:27,490
+المفروض إذا a is x إذا في عندي متغير اسمه a وقيمته
+
+274
+00:21:27,490 --> 00:21:31,870
+x إذا هذا الكلام صحيح إذا هذا الكلام صحيح فمعنى
+
+275
+00:21:32,080 --> 00:21:36,500
+معنى ذلك بقدر استنتج أن P قيمة Y هذا الكلام لم أكن
+
+276
+00:21:36,500 --> 00:21:40,320
+أعرف إذا كان صحيح أو ليس صحيح إلا إذا وجدت في ال
+
+277
+00:21:40,320 --> 00:21:46,460
+fact حاجة تقول إن فعلًا نعم A قيمة X إذا هذا
+
+278
+00:21:46,460 --> 00:21:50,320
+الكلام معطى معنى ذلك أن هذا ال rule تحققت معنى ذلك
+
+279
+00:21:50,320 --> 00:21:54,420
+أن هذا ال conclusion أصبحت حقيقة مصبوط و واقع
+
+280
+00:21:54,420 --> 00:21:59,540
+فبقدر أمسك هذه و أضيفها ك cash ك fact في ال memory
+
+281
+00:21:59,540 --> 00:22:04,050
+short termصار عندي shorter memo لان فيها معلومة
+
+282
+00:22:04,050 --> 00:22:10,890
+جديدة بعيد تاني .. بعيد تاني ال cycle و بقى اشوف
+
+283
+00:22:10,890 --> 00:22:15,770
+هذه الجديدة و ايضا الجديمة هذه ال facts الجديمة هل
+
+284
+00:22:15,770 --> 00:22:22,030
+اصبح لان في rules أخرى ممكن أستنبط
+
+285
+00:22:22,030 --> 00:22:27,130
+ال conclusion تبعتها بيتم العمل هذا دورة و ر دورة
+
+286
+00:22:27,130 --> 00:22:29,690
+إلى أن اصل إلى
+
+287
+00:22:31,880 --> 00:22:36,160
+conclusion بتجاوب على السؤال اللي انا بديها بتجاوب
+
+288
+00:22:36,160 --> 00:22:39,660
+على السؤال اللي انا بديها خلاني اطلع مثلا على ال
+
+289
+00:22:39,660 --> 00:22:43,080
+example
+
+290
+00:22:43,080 --> 00:22:51,500
+هنا انا approved تلاتة rules تمام انا الان هدفي ان
+
+291
+00:22:51,500 --> 00:23:00,290
+اصل الى قيمة ال z قيمة ال ايش ال zهل هي true ولا
+
+292
+00:23:00,290 --> 00:23:04,690
+false؟ بدي أعرف بس بناء على إيش بدي أعرف؟ بناء على
+
+293
+00:23:04,690 --> 00:23:08,530
+المواضيع اللي لدي حسب ال rules حسب المواضيع وحسب
+
+294
+00:23:08,530 --> 00:23:11,910
+ال rules ال rules لحالها أنا مابقدر أشغلها أو
+
+295
+00:23:11,910 --> 00:23:16,830
+أصنبط منها إلا بناء على ال data على facts okay
+
+296
+00:23:16,830 --> 00:23:22,910
+فالأن زيادة عشان أعرف الكلب true ولا false لازم
+
+297
+00:23:22,910 --> 00:23:28,610
+أطلع على مين؟ على Y و D من وين هذا الكلب أجاه؟أجل
+
+298
+00:23:28,610 --> 00:23:34,810
+لأن هنا في rule رقم واحد بتقول if y is true and d
+
+299
+00:23:34,810 --> 00:23:39,290
+is true يبقى z is true طب انا الآن صار بدي أعرف ال
+
+300
+00:23:39,290 --> 00:23:42,570
+y و ال d هدولة true ولا false لازم أشوف ال y لحالة
+
+301
+00:23:42,570 --> 00:23:47,430
+و أشوف ال d لحالةالان عشان انا .. ال D .. ال D
+
+302
+00:23:47,430 --> 00:23:51,070
+مافيش rule .. مافيش rule بتقول اذا كذا كذا then D
+
+303
+00:23:51,070 --> 00:23:55,770
+كده كده يعني هذا يجب تعطيلي ك fact يعني لازم انا
+
+304
+00:23:55,770 --> 00:23:59,910
+اسم .. لأ لازم ال system يسأل ال user عنها يقوله
+
+305
+00:23:59,910 --> 00:24:04,730
+هل D إيش وضع D هل هي true ولا false تمام؟ اللي انا
+
+306
+00:24:04,730 --> 00:24:08,750
+بدي أعرف ال why مازال فيه rule بتصب فيها بسألش
+
+307
+00:24:08,750 --> 00:24:15,640
+وراح نشوف ال rule okay تمام؟ بتبدي نطلع علىالعناصر
+
+308
+00:24:15,640 --> 00:24:22,100
+تبعتها ال X والB والE هؤلاء لازم ياخدهم ال user
+
+309
+00:24:22,100 --> 00:24:28,380
+هادي بيستنبطها القيمة X من قيمة A من أين هذا
+
+310
+00:24:28,380 --> 00:24:31,400
+الكلام أجا من هذا اجا من هذا اقول if A is true
+
+311
+00:24:31,400 --> 00:24:36,680
+then X is true انا عمليا الان اللي حكيته مش
+
+312
+00:24:36,680 --> 00:24:39,740
+forward chaining هو backward chaining أنا جيت من
+
+313
+00:24:39,740 --> 00:24:43,570
+ال Z ورجعت رجوعبينما الكلام اللي كنا بنحكي فيه في
+
+314
+00:24:43,570 --> 00:24:48,110
+الأول ان انا لأ ان انا ببدأ من اللي مابه ماشي يعني
+
+315
+00:24:48,110 --> 00:24:53,230
+لازم اكون عندي ال a قيمتها معلومة و ال b قيمتها
+
+316
+00:24:53,230 --> 00:24:58,870
+معلومة و ال e قيمتها معلومة و ال h و ال d قيمتها
+
+317
+00:24:58,870 --> 00:25:04,570
+معلومة الآن بأمسك ال rules تبعتي واحدة و لا تانية
+
+318
+00:25:04,570 --> 00:25:07,030
+هذا ال expert system ال inference engine بمسك ال
+
+319
+00:25:07,030 --> 00:25:11,650
+rules بيقول ال rule رقم واحدإيش الشرط تبعها Y وD
+
+320
+00:25:11,650 --> 00:25:20,250
+هل في عندي هنا إشي يغطي الشرط هذا عند ال D بكل
+
+321
+00:25:20,250 --> 00:25:25,650
+user مدخلها بس ال Y مابعرفش يبجي هذا ال rule الشرط
+
+322
+00:25:25,650 --> 00:25:32,190
+تبعها مش معروف مش معروف صحته من عدمه هذا في ال
+
+323
+00:25:32,190 --> 00:25:36,530
+forwardفي ال forward أنا ببدأ من ال rules ببدأ من
+
+324
+00:25:36,530 --> 00:25:40,590
+الحقائق اللي معايا وبشوف من من ال rules الشرط
+
+325
+00:25:40,590 --> 00:25:47,250
+تبعها فيه هناك ما يسنده من الحقائق إذا واحدة من ال
+
+326
+00:25:47,250 --> 00:25:51,750
+rules الشرط تبعها فيه حقائق بتسنده معناه ذلك اللي
+
+327
+00:25:51,750 --> 00:25:56,050
+بنقول ان ال rule is fires fire يعني كإني أنا ضغطت
+
+328
+00:25:56,050 --> 00:26:02,040
+زناد البندقية أو المسدسمتى ال rule fires لما ال
+
+329
+00:26:02,040 --> 00:26:06,220
+condition تبعها بيكون فيه ياندي معطيات بتسنده؟ إذا
+
+330
+00:26:06,220 --> 00:26:08,920
+في معطيات بتسنده، معناة ال rule fires إيش معناة
+
+331
+00:26:08,920 --> 00:26:12,540
+fires؟ يعني إيش اللي بينتج عن ذلك؟ بينتج عن ذلك إن
+
+332
+00:26:12,540 --> 00:26:16,980
+ال conclusion تبعتها بتصبح معلومة، تمام؟ أنا الآن
+
+333
+00:26:16,980 --> 00:26:20,720
+أفترض إن هذا معروف و هذا معروف و هذا معروف، مين من
+
+334
+00:26:20,720 --> 00:26:26,120
+ال rules هدولة الآن ممكن
+
+335
+00:26:26,120 --> 00:26:31,270
+to fire؟ أفترض إن هدولة معروفينال rule هذه بنزمها
+
+336
+00:26:31,270 --> 00:26:36,490
+ال y و ال d عند ال d بس ماعنديش ال y بقدرش to fire
+
+337
+00:26:36,490 --> 00:26:41,870
+هذا ال rule هذه بده ال x و بده ال b و بده ال e ال
+
+338
+00:26:41,870 --> 00:26:45,310
+b و ال e موجودة بس ال x مش موجودة بينما هذه بده بس
+
+339
+00:26:45,310 --> 00:26:49,890
+ال a و ال a موجودة يعني هذا ال rule fires fire
+
+340
+00:26:49,890 --> 00:26:56,550
+يعني ال conclusion بتتحقق تتحقق يعني x is true بس
+
+341
+00:26:56,550 --> 00:27:02,980
+يا راني معلومة جديدة هتنبع في وين هذه الكلامعلى ال
+
+342
+00:27:02,980 --> 00:27:13,520
+facts اللي هي short term memory طيب الآن صارت X
+
+343
+00:27:13,520 --> 00:27:19,760
+معلومة in the trueخلصنا احنا ال cycle الأولى
+
+344
+00:27:19,760 --> 00:27:23,620
+ففرّينا على ال rules كلها لمّا واحدة منهم fired
+
+345
+00:27:23,620 --> 00:27:30,540
+فنفّذناها ورجعنا تاني cycle جديد ال cycle الجديد
+
+346
+00:27:30,540 --> 00:27:34,380
+نمر عليهم نار بنفس الترتيب ال rule الأولى هل can
+
+347
+00:27:34,380 --> 00:27:38,820
+be fired لسه لأن ال why لسه مش معلومة هذه عند ال E
+
+348
+00:27:38,820 --> 00:27:41,580
+وعند ال B وعندي أصلها عند ال X يبقى fires يبقى
+
+349
+00:27:41,580 --> 00:27:46,360
+الان firing ال rule رقم 2 معناه ناشط ال conclusion
+
+350
+00:27:46,360 --> 00:27:52,720
+تبعتهاwill be activated يعني سيكون صحيح فالـ C and
+
+351
+00:27:52,720 --> 00:28:00,920
+Y تسجل و القيمة تبعتها خلاص
+
+352
+00:28:00,920 --> 00:28:05,540
+مجرد أن واحد من ال rules fires خلاص بنهي ال cycle
+
+353
+00:28:05,540 --> 00:28:08,900
+و بابت cycle جديد بانفذش اكتر من ال rule في ال
+
+354
+00:28:08,900 --> 00:28:17,940
+cycle نفسها بدأنا جديد الآن ف .. فإيش؟صار في اندي
+
+355
+00:28:17,940 --> 00:28:22,960
+ال y موجودة و ال d موجودة فبقدر اد ال rule لان
+
+356
+00:28:22,960 --> 00:28:29,380
+تتطبق و بعرف ال z الآن ال z بناء على ال example
+
+357
+00:28:29,380 --> 00:28:33,900
+هذه ال z هي ال goal تبعي هي المتغير اللي انا بدي
+
+358
+00:28:33,900 --> 00:28:39,920
+اعرف قيمته فخلاص علمت القيمة تبعته طبعا كيف علمت
+
+359
+00:28:39,920 --> 00:28:45,660
+القيمة نفدت ال rule ايش نفدت صارت zموجود عندى فى
+
+360
+00:28:45,660 --> 00:28:49,960
+ال short term memory و القيمة تبعتها معروفة فيبقى
+
+361
+00:28:49,960 --> 00:28:54,700
+وين ال termination condition لها ال cycle هى دى ال
+
+362
+00:28:54,700 --> 00:28:56,480
+termination condition ايش يعني termination
+
+363
+00:28:56,480 --> 00:29:02,880
+condition يعني شط ايقاف الدوران هذا اللى هو انه ال
+
+364
+00:29:02,880 --> 00:29:06,860
+goal تبعتى يصبح موجود فى ال short term memory اذا
+
+365
+00:29:06,860 --> 00:29:11,420
+وجه ال goal فى ال short term memory بنجف و بنعطيه
+
+366
+00:29:11,420 --> 00:29:12,700
+القيمة تبعته
+
+367
+00:29:16,500 --> 00:29:20,620
+ما هو هو هنا في المثال هذا السؤال تبعنا ما هي الـ
+
+368
+00:29:20,620 --> 00:29:24,000
+Boolean value أو ال truth value تبع ال Z هل هو ال
+
+369
+00:29:24,000 --> 00:29:27,320
+false ولا ال true؟ ماشي احنا هذا اللي بنعرفه،
+
+370
+00:29:27,320 --> 00:29:31,460
+بنعرف إنه true ولا false، مش بدنا يكون true، احنا
+
+371
+00:29:31,460 --> 00:29:35,440
+بنعرف بناء على الموقعات اللي متوفرة معانا من
+
+372
+00:29:35,440 --> 00:29:40,090
+البداية، هل ال Z موقعها true ولا false؟ تمام؟يعني
+
+373
+00:29:40,090 --> 00:29:44,870
+مثلا ممكن اعطيك مسألة ان والله بدنا نعرف فلان
+
+374
+00:29:44,870 --> 00:29:48,130
+لفلان هل هو موجود الان المدرس الفلاني موجود الان
+
+375
+00:29:48,130 --> 00:29:51,450
+في مكتبه ولا لأ تمام؟ بدناش نروح المكتب و ندق
+
+376
+00:29:51,450 --> 00:29:55,070
+الباب و نشوف بس بدنا ناخد معطيات نفترض ان في
+
+377
+00:29:55,070 --> 00:29:59,730
+معطيات ممكن نستند اليها فبصير المسألة هي هل موجود
+
+378
+00:29:59,730 --> 00:30:04,810
+في مكانه ولا لأ اه بناء على المعطيات بتتحللوبناء
+
+379
+00:30:04,810 --> 00:30:08,430
+على ال rules والله إذا كان .. إذا كان الساعة من
+
+380
+00:30:08,430 --> 00:30:12,790
+كده لكده فهو ماعندوش محاضرة طيب عندوش محاضرة هل
+
+381
+00:30:12,790 --> 00:30:16,530
+معناه ذلك إن هو في المكتب؟ لأ إذا والله عنده ..
+
+382
+00:30:16,530 --> 00:30:20,010
+ففيبقى في مجموعة من ال rules ومجموعة بسيطة من
+
+383
+00:30:20,010 --> 00:30:24,350
+الحقائق على أساسها بيتم استنباط أو inferring ال
+
+384
+00:30:24,350 --> 00:30:27,590
+إيش ال conclusion اللي هي اللي هي هو موجود في
+
+385
+00:30:27,590 --> 00:30:31,070
+المكتب ولا مش موجود طبعا فاحنا الآن يفترض ووضحت
+
+386
+00:30:31,070 --> 00:30:37,620
+عندنا آلية ال إيشقالية عمل مرة تانية قالية عمل ال
+
+387
+00:30:37,620 --> 00:30:41,960
+inference engine هي عبارة عن ال cycles match fire
+
+388
+00:30:41,960 --> 00:30:46,700
+procedure match cycles of match fire match يعني
+
+389
+00:30:46,700 --> 00:30:50,300
+بنطابق المطالبات اللي موجودة في ال short term
+
+390
+00:30:50,300 --> 00:30:53,700
+memory أو في ال database المحطتها مع إيش بنطابقها
+
+391
+00:30:53,700 --> 00:30:58,220
+مع إيش أو بنبحث عنها في إيش في ال conditions تبع
+
+392
+00:30:58,220 --> 00:31:01,580
+ال rules إذا لجينا ال rule ال condition تبعها
+
+393
+00:31:01,580 --> 00:31:08,490
+كاملامطابق بيه ال facts يبقى هذا ال rule ماشي
+
+394
+00:31:08,490 --> 00:31:13,230
+fires fires يعني ال conclusion تبعتها تصبح حقيقة
+
+395
+00:31:13,230 --> 00:31:17,670
+تضاف إلى ال short term memory و بنكرر و بنكرر إلى
+
+396
+00:31:17,670 --> 00:31:24,650
+أن ال cycle تستمر إلى أن المتغير اللي احنا بنبحث
+
+397
+00:31:24,650 --> 00:31:29,910
+عنه يصبح موجود في ال short term هذا ال forward
+
+398
+00:31:29,910 --> 00:31:35,410
+changingهذه الـ slide بتوضح نفس المثال اللي حكيناه
+
+399
+00:31:35,410 --> 00:31:41,090
+فيه Cycle Cycle Cycle Cycle Cycle Cycle Cycle
+
+400
+00:31:41,090 --> 00:31:41,430
+Cycle Cycle Cycle Cycle Cycle Cycle Cycle Cycle
+
+401
+00:31:41,430 --> 00:31:42,530
+Cycle Cycle Cycle Cycle Cycle Cycle Cycle Cycle
+
+402
+00:31:42,530 --> 00:31:42,950
+Cycle Cycle Cycle Cycle Cycle Cycle Cycle Cycle
+
+403
+00:31:42,950 --> 00:31:43,030
+Cycle Cycle Cycle Cycle Cycle Cycle Cycle Cycle
+
+404
+00:31:43,030 --> 00:31:54,190
+Cycle Cycle Cycle Cycle Cycle
+
+405
+00:31:54,190 --> 00:31:57,210
+Cy
+
+406
+00:32:02,720 --> 00:32:10,160
+هذا هو قيمته بحث الآن برضه في ال rules ولكن بطلع
+
+407
+00:32:10,160 --> 00:32:14,480
+مش على ال condition بطلع على ال conclusion ببحث عن
+
+408
+00:32:14,480 --> 00:32:20,580
+مين من ال rules مين من ال rules ال conclusion
+
+409
+00:32:20,580 --> 00:32:27,460
+تبعتها مش ال true بتجيب سيرة ال variable اللي أنا
+
+410
+00:32:27,460 --> 00:32:30,760
+بدور عليه هل هذه بتجيب سيرة ال variable
+
+411
+00:32:34,060 --> 00:32:38,420
+هذه الأولى بس هي ليش اللى بتمكّدني أن أستنبط
+
+412
+00:32:38,420 --> 00:32:44,200
+القيمة تبع ال Z حلو مازال مازال هادى يبقى الآن أنا
+
+413
+00:32:44,200 --> 00:32:49,780
+بحب أخد ال condition تبعها و إيش بسوا فيه بعتبره
+
+414
+00:32:49,780 --> 00:32:54,780
+بهم الآن goals بصير أنا أبحث عن ال Y و عن ال D
+
+415
+00:32:54,780 --> 00:33:01,080
+ماشي الحال فبصير ألف بحث عن meaning of rules و
+
+416
+00:33:01,080 --> 00:33:06,730
+أجيب سيرة ال Y ال Y في الأول طبعاهذه طيب و حلوة
+
+417
+00:33:06,730 --> 00:33:10,150
+هذه بتقول لي قيمة ال Y ولكن مش طلع تقول لي ان في
+
+418
+00:33:10,150 --> 00:33:15,990
+عندي قيم ال X و ال B بيصير ناخدهم هم ك sub goals
+
+419
+00:33:15,990 --> 00:33:19,830
+فبتدرج انا من ال goal الأساسي اللي هو ال Z الى sub
+
+420
+00:33:19,830 --> 00:33:24,150
+goals اللي بتحدد
+
+421
+00:33:24,150 --> 00:33:28,410
+ليها ال rules هذا ايش اسمه هذا ال background؟
+
+422
+00:33:28,410 --> 00:33:33,580
+شوكات زي ايه قد سؤال المفروض ياطلر من D2بالظبط هو
+
+423
+00:33:33,580 --> 00:33:38,180
+لازم اي مسألة .. اي مسألة مابتقدرش انت او ال
+
+424
+00:33:38,180 --> 00:33:41,940
+system ايه يعالجها الا بناء على المعطيات لازم تبقى
+
+425
+00:33:41,940 --> 00:33:49,180
+توفر المعطيات صح او لا طيب احنا الان ايش بيبقى
+
+426
+00:33:49,180 --> 00:33:53,900
+نقدر نسوي في الواجهة ده خلينا نرخص بس الحكينات
+
+427
+00:33:53,900 --> 00:33:57,580
+احنا صبنا حكينا عن ال structure تبع ال rule based
+
+428
+00:33:57,580 --> 00:34:00,140
+express system انا بقول rule based express system
+
+429
+00:34:00,140 --> 00:34:02,940
+لأنه في انواع اخرى من ال express systemsما هيش
+
+430
+00:34:02,940 --> 00:34:06,900
+rule based زي ال case based مثلا بعدين حكينا عن ال
+
+431
+00:34:06,900 --> 00:34:10,420
+forward chaining و ال backward chaining دلنا نحكي
+
+432
+00:34:10,420 --> 00:34:13,300
+عن ال conflict resolution ال conflict resolution
+
+433
+00:34:13,300 --> 00:34:17,980
+اللي هو لما نكون في عندي أكتر من rule اه يعني
+
+434
+00:34:17,980 --> 00:34:20,880
+افترض ان احنا شغالين forward chaining forward
+
+435
+00:34:20,880 --> 00:34:25,600
+chaining و هنا انا دجيت ان ال rule اللي كنتش تبعها
+
+436
+00:34:25,600 --> 00:34:30,400
+و ال rule تاني برضه كنتش تبعها عملوا matching مش
+
+437
+00:34:30,400 --> 00:34:36,040
+هنعملوا matchingيعني الحقائق المتوفرة بتسند هذه
+
+438
+00:34:36,040 --> 00:34:41,000
+وبتسند هذهك اختار مين منهم هذا اسمه conflict two
+
+439
+00:34:41,000 --> 00:34:46,820
+rules متزاحمة على انه to be fired يعني to be
+
+440
+00:34:46,820 --> 00:34:50,480
+executed فأطبق مين منهم هذا الكلام نحكيه في
+
+441
+00:34:50,480 --> 00:34:54,740
+المحاضرة التالية فيه أكتر من رؤة يعني strategy ل
+
+442
+00:34:54,740 --> 00:34:58,710
+ال conflict resolutionو المحاضرة الجاية برضه بنكمل
+
+443
+00:34:58,710 --> 00:35:01,010
+الى قضية ال characteristics وما إلى ذلك ماشي
+
+444
+00:35:01,010 --> 00:35:01,610
+أعطيكم العافية
+
diff --git a/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/f6_eLzRXoWg_raw.srt b/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/f6_eLzRXoWg_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..a858e97f1f1835e04446e9e283182126929c3610
--- /dev/null
+++ b/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/f6_eLzRXoWg_raw.srt
@@ -0,0 +1,1804 @@
+1
+00:00:20,700 --> 00:00:22,800
+ماشى بسم الله الرحمن الرحيم المحاضرة هاد ان شاء
+
+2
+00:00:22,800 --> 00:00:27,220
+الله احنا المفروض ننتقل لموضوع مختلف تماما ومختلف
+
+3
+00:00:27,220 --> 00:00:31,800
+عن ال .. اللي هو ال problem solving by search بس
+
+4
+00:00:31,800 --> 00:00:38,300
+بدنا نجف عن نقطتين صغار تكملة او متابعة لاخر اشي
+
+5
+00:00:38,300 --> 00:00:41,080
+حكيناه في المحاضرة الماضية المحاضرة الماضية احنا
+
+6
+00:00:41,080 --> 00:00:43,620
+كنا بنحكي عن ال alpha beta pruning وكان في انا
+
+7
+00:00:43,620 --> 00:00:47,630
+example اللي هو هذا المثالهذا المثال الـ tree هذه
+
+8
+00:00:47,630 --> 00:00:51,070
+و كده ماشينا في الـ pruning تبعها و بدأنا من
+
+9
+00:00:51,070 --> 00:00:54,690
+الشمال لليمين كانت انا two rules أساسية بنطلع
+
+10
+00:00:54,690 --> 00:00:58,370
+عليها علشان نعمل الـ pruning اللي هو انه ال .. اذا
+
+11
+00:00:58,370 --> 00:01:02,790
+انا على main level تمام؟ و ال node اللي انا واقف
+
+12
+00:01:02,790 --> 00:01:06,710
+عليها ال beta تبعها ال beta تبعها لمين اجا؟ اجا
+
+13
+00:01:06,710 --> 00:01:11,070
+بعد استكشاف ال children تمام؟ و بيضلوا beta بيضلوا
+
+14
+00:01:11,070 --> 00:01:14,190
+محتمل الى ان نستنفذ كل ال children
+
+15
+00:01:16,490 --> 00:01:21,610
+بس طالما ان هو لسه ماتبعدش فهو beta إذا ال beta
+
+16
+00:01:21,610 --> 00:01:26,590
+هذا كان أقل من أو يساوي ال alpha تبع ال parent تبع
+
+17
+00:01:26,590 --> 00:01:32,250
+ال node نقدر نوقف مافيش داعي نستمر لأنه عالفاضي و
+
+18
+00:01:32,250 --> 00:01:36,130
+الأكس من ذلك في حالة إذا كنا على ال max level إذا
+
+19
+00:01:36,130 --> 00:01:40,210
+كنا على ال max level بدنا نطلع إذا ال alpha تبعت
+
+20
+00:01:40,210 --> 00:01:45,350
+ال node أكبر من أو أقل من ال beta تبعت من ال
+
+21
+00:01:45,350 --> 00:01:49,240
+parentبرضه بننقل ماشي اللي اشتبه عليكم المحاضرة
+
+22
+00:01:49,240 --> 00:01:52,680
+اللي فاتت انه لو انت بصيت Alpha أكبر من أو يساوي
+
+23
+00:01:52,680 --> 00:01:56,700
+Beta هتطلع ماهي نفسها برضه Alpha أكبر من أو يساوي
+
+24
+00:01:56,700 --> 00:02:00,300
+Beta لو أخدتها انت فاشتبه عليكم ان هي نفس ال rule
+
+25
+00:02:00,300 --> 00:02:03,420
+بس واقعي الأمر انه مش نفس ال rule لأن هنا احنا
+
+26
+00:02:03,420 --> 00:02:06,120
+بنحكي عن Alpha تبع ال parent بينما هنا Alpha تبع
+
+27
+00:02:06,120 --> 00:02:09,660
+ال node وهنا بنحكي عن Beta تبع ال parent بينما هنا
+
+28
+00:02:09,660 --> 00:02:16,460
+Beta تبع ال nodeنقطة استحقت ان احنا نراجحها بخصوص
+
+29
+00:02:16,460 --> 00:02:18,860
+محاضرة الفادات النقطة التانية اللي هي ان احنا لو
+
+30
+00:02:18,860 --> 00:02:24,260
+احنا بنعمل programming في شغلتين صغار يعني بدنا
+
+31
+00:02:24,260 --> 00:02:29,160
+نرجعهم اول اشي ان هنا ال B ال B لما احنا عملنا
+
+32
+00:02:29,160 --> 00:02:31,660
+programming لمحاضرة الفادات كملنا بعد ما شوفنا
+
+33
+00:02:31,660 --> 00:02:35,900
+الخمسة كملنا معاهم هذا الكلام مش مفروض ليش لأنه
+
+34
+00:02:35,900 --> 00:02:40,520
+كانت ال alpha تابعة البعد ما ال B شافت ال child
+
+35
+00:02:40,520 --> 00:02:44,080
+الأولاني ويقوله خمسة already هذه خمسة أكبر من
+
+36
+00:02:44,080 --> 00:02:48,360
+الألفة
+
+37
+00:02:48,360 --> 00:02:51,440
+أكبر من ال beta تبع ال parent يبقى المفروض أن أنا
+
+38
+00:02:51,440 --> 00:02:56,780
+أوقف هنا لم أوقف ناش صح فهذا لازم يصحح بالظبط
+
+39
+00:02:56,780 --> 00:03:01,620
+فالان احنا نجرب ال B شوف ال child الأول و تكتشف أن
+
+40
+00:03:01,620 --> 00:03:05,380
+ال value تبعه خمسة في الألفة تبعها ليش الألفة
+
+41
+00:03:05,380 --> 00:03:09,020
+تبعها لأن أنا في level maxالألف ده بقتها ساعة خمسة
+
+42
+00:03:09,020 --> 00:03:13,520
+خمسة أكبر من تلاتة يبقى إيش لازم توقف ال search
+
+43
+00:03:13,520 --> 00:03:17,280
+لازم توقف ال search وما تتطلعش على ال child هذا
+
+44
+00:03:17,280 --> 00:03:20,640
+أوي إذا حتى في children أخر منا هذا النقطة الأولى
+
+45
+00:03:20,640 --> 00:03:23,260
+اللي هي أن ال proning لازم نحصل ال proning هنا
+
+46
+00:03:23,260 --> 00:03:27,540
+النقطة التانية أنه احنا في المرة الفاترة اعتبرنا
+
+47
+00:03:27,540 --> 00:03:31,500
+أن ال zero ماهواش lowest بمعنى أنه في احتمال يكون
+
+48
+00:03:31,500 --> 00:03:35,200
+في أقل من zero لذلك استمرنا استمرنا ببحث عن level
+
+49
+00:03:35,200 --> 00:03:41,320
+منالـ Min لم يعد مستمر، شفت الـ Zero لكن استمرت
+
+50
+00:03:41,320 --> 00:03:45,300
+لأنه قد يكون فيه أقل من الـ Zero إذا مُعطى إليك في
+
+51
+00:03:45,300 --> 00:03:51,020
+المثل أن الـ Zero هو ال minimum possible value
+
+52
+00:03:51,020 --> 00:03:56,290
+يبقى بتوقف، خلاص، مافيش إذا شُفت Child0 وكانت هنا
+
+53
+00:03:56,290 --> 00:04:00,810
+beta 0 مافي داعي لأنه مافي ممكن اتوقع اقل من 0 اذا
+
+54
+00:04:00,810 --> 00:04:04,910
+هذا الكلام موضح اليك في المسألة فبتحط pruning هنا
+
+55
+00:04:04,910 --> 00:04:09,930
+صح النقطة هذه سوناها مظبوط زي هيك فمافيش اي مشكلة
+
+56
+00:04:09,930 --> 00:04:15,150
+احنا حكينا عن نقطتين النقطة الأولى اللي هي rules
+
+57
+00:04:15,150 --> 00:04:22,850
+النقطة التانية اللي هيقالية ال proning اللي سوناها
+
+58
+00:04:22,850 --> 00:04:26,210
+النقطة التالتة ان احيانا ممكن تجيلك مسألة ينطلب
+
+59
+00:04:26,210 --> 00:04:31,910
+فيها منك تعمل right to left proning احنا كنا
+
+60
+00:04:31,910 --> 00:04:35,990
+شغالين على الدوام left to right proning لو انطلب
+
+61
+00:04:35,990 --> 00:04:39,210
+منك right to left نفس الجثة مااختلفتش بس هيطلع
+
+62
+00:04:39,210 --> 00:04:43,970
+جواب مختلف يعني لما انا اعمل Q&A 3 و اعمل left to
+
+63
+00:04:43,970 --> 00:04:50,640
+right proning اه هيطلعال proning نفس لو انا بدي
+
+64
+00:04:50,640 --> 00:04:57,740
+اعمل right to left حتما لانه .. ليش؟ لأنه انا بشوف
+
+65
+00:04:57,740 --> 00:05:00,500
+notes غير عن اللي هشوفها .. هشوف notes من الأول و
+
+66
+00:05:00,500 --> 00:05:03,580
+غير عن اللي هشوفها من .. لو جيت من الاتجاه التاني،
+
+67
+00:05:03,580 --> 00:05:07,860
+مظبوط؟ فال .. هذا ف .. هذا بس مطلة تالتة حابيت أنا
+
+68
+00:05:07,860 --> 00:05:10,580
+و هقلها اللي .. اللي .. اللي ممكن المسألة اللي
+
+69
+00:05:10,580 --> 00:05:13,860
+انطلب فيك .. انطلب فيها منك انك تعمل ال right to
+
+70
+00:05:13,860 --> 00:05:17,220
+left او يطلبك شغلتين left to right و right to left
+
+71
+00:05:18,080 --> 00:05:23,100
+مش مشكلة نفس القالية طيب هيك احنا بنكون خلصنا ايه
+
+72
+00:05:23,100 --> 00:05:26,760
+اللي بدنا نذكره عن المحاضرة .. التعليق على
+
+73
+00:05:26,760 --> 00:05:29,940
+المحاضرة اللي فاتت و بدنا نبدأ الآن في اللي هو
+
+74
+00:05:29,940 --> 00:05:32,840
+الموضوع الجديد .. الموضوع الجديد و من الكتاب
+
+75
+00:05:32,840 --> 00:05:36,780
+التاني الكتاب التاني اللي هو عندك هنا على ال drop
+
+76
+00:05:36,780 --> 00:05:42,240
+box في ال student folder في بداخله موجود في two
+
+77
+00:05:42,240 --> 00:05:46,060
+sub folders واحدة من الكتابينالكتاب اللى احنا بدنا
+
+78
+00:05:46,060 --> 00:05:49,720
+نشتغل باله اللى هو ال guide to intelligent systems
+
+79
+00:05:49,720 --> 00:05:53,880
+فى بداخله sub folder للسلايدات و فى بداخله pdf
+
+80
+00:05:53,880 --> 00:05:58,300
+file للكتاب نفسه ماشي انا بدى اعرض ال table of
+
+81
+00:05:58,300 --> 00:06:03,340
+contents تبع الكتاب الكتاب في حوالى 14 chapter
+
+82
+00:06:03,340 --> 00:06:06,960
+احنا هنبدأ من ال chapter التانى يتكلم عن google
+
+83
+00:06:06,960 --> 00:06:10,400
+based expert systems احنا الموضوع اللى دي عمليا هو
+
+84
+00:06:10,400 --> 00:06:11,660
+عن ال expert systems
+
+85
+00:06:16,200 --> 00:06:19,800
+و نوع محدد من ال expert systems اللي هو rule based
+
+86
+00:06:30,920 --> 00:06:33,740
+مشي هنطلع في الأول إيش يعني rules و بعدين إيش يعني
+
+87
+00:06:33,740 --> 00:06:35,960
+rule basics بال system و إيش هي ال structure تبع
+
+88
+00:06:35,960 --> 00:06:39,460
+ال rule basics بال system يعني تقريبا هنغطي كافة
+
+89
+00:06:39,460 --> 00:06:42,900
+اللي هو ال succession تبع هذا ال chapter و نكمل
+
+90
+00:06:42,900 --> 00:06:46,160
+بعد هيك الشباتر التاني بس مش هناخد ال 14 chapter
+
+91
+00:06:46,160 --> 00:06:50,910
+كلهم غالبا هنقصر بس لعنده عشرات أو أحد عشرأحنا
+
+92
+00:06:50,910 --> 00:06:53,590
+موضوعنا اليوم ان شاء الله عن ال rule based express
+
+93
+00:06:53,590 --> 00:07:00,090
+system ففي عندنا سلايدات اللي هم اصلا مع الكتاب
+
+94
+00:07:00,090 --> 00:07:04,170
+اللي هو عندي هذا ال slide هذي okay rule based
+
+95
+00:07:04,170 --> 00:07:09,290
+express system تمام
+
+96
+00:07:09,290 --> 00:07:13,110
+فاحنا هنتقلع عليها بس مش بنفس الترتيب السلايدات
+
+97
+00:07:13,110 --> 00:07:19,730
+اللي هم مرتبين هنا بدي أخدهم بترتيب مختلف شويةيعني
+
+98
+00:07:19,730 --> 00:07:29,390
+احنا بيكتب السيكاشة اللي هنمشي عليها في هذا الشرطر
+
+99
+00:07:29,390 --> 00:07:39,330
+كأننا عملين لان هبدأ في ال structure of
+
+100
+00:07:39,330 --> 00:07:46,990
+اللي هو rule based expert systems وبعدين نطلع على
+
+101
+00:08:01,590 --> 00:08:06,750
+الانفرانس ميكانيزم و بعدين هنطلع على conflict
+
+102
+00:08:06,750 --> 00:08:07,250
+resolution
+
+103
+00:08:18,450 --> 00:08:22,550
+بالتالي، هذا الكلام يجعلنا أننا في الـ slides نذهب
+
+104
+00:08:22,550 --> 00:08:30,410
+على
+
+105
+00:08:30,410 --> 00:08:32,810
+طول على النقطة هذه الـ Structure أو الـ Rule
+
+106
+00:08:32,810 --> 00:08:37,770
+Basics في الـ System ثم هنا، بعدها الـ Conflict
+
+107
+00:08:37,770 --> 00:08:42,910
+Resolution النقاط التانيبنرجعلها بعد .. بعد ما
+
+108
+00:08:42,910 --> 00:08:46,650
+نخطف فكرة عن قليلة عمل لل Express System بنطلع على
+
+109
+00:08:46,650 --> 00:08:51,670
+ال main players in the development of the team و
+
+110
+00:08:51,670 --> 00:08:54,950
+ايضا كذا كهال characteristics of Express System ال
+
+111
+00:08:54,950 --> 00:08:57,790
+introduction هتكون احنا غطينا محتوىها و احنا
+
+112
+00:08:57,790 --> 00:09:01,660
+بنتكلم يعنى تمام؟ فاحنا الان امامالحاجة اسمها ال
+
+113
+00:09:01,660 --> 00:09:04,080
+express system ال express system يعني اللي هو
+
+114
+00:09:04,080 --> 00:09:08,000
+النظام الخبير النظام الخبير هذا عبارة عن نوع من
+
+115
+00:09:08,000 --> 00:09:11,920
+التطبيقات اللي بيستخدم في الحياة العملية غالبا في
+
+116
+00:09:11,920 --> 00:09:15,820
+ال business ولا في الطب ولا في ال maintenance
+
+117
+00:09:15,820 --> 00:09:19,520
+والصيانة والتشخيص وكده اللي مقصود ب express system
+
+118
+00:09:19,520 --> 00:09:24,780
+أيش؟ مقصود بيه هو عبارة عن system يحل محل كلمة يحل
+
+119
+00:09:24,780 --> 00:09:29,830
+محل حُط تحتها خطلأنه مافي system هيقدر يحل محال ال
+
+120
+00:09:29,830 --> 00:09:32,990
+human expert ايش عن ال human expert خبير البشري
+
+121
+00:09:32,990 --> 00:09:36,010
+ايش عن الخبير البشري يعني انسان مختص في مجال معين
+
+122
+00:09:36,010 --> 00:09:40,590
+الطبيب مختص في مجاله الفن الصيانة مختص في مجال
+
+123
+00:09:40,590 --> 00:09:44,850
+عمله الموظف اللي في البنك اللي بيقرر جديش يعطي
+
+124
+00:09:44,850 --> 00:09:48,210
+القروض و اللي ماهي دلوقتي هذا مختص في مجاله فاحنا
+
+125
+00:09:48,210 --> 00:09:55,070
+إذا كان قدرنا نعمل system اللي يحاكيهذا الدور اللي
+
+126
+00:09:55,070 --> 00:09:59,450
+هو عملية اتخاذ القرار في المجالات المختلفة هذه
+
+127
+00:09:59,450 --> 00:10:04,530
+فبسميه Express System الإشكالية الأساسية في عمل
+
+128
+00:10:04,530 --> 00:10:09,290
+هذا ال system انه العلم والمعرفة والتخصص اللي
+
+129
+00:10:09,290 --> 00:10:14,630
+بيفهمه هذا الشخص كيف انعبر عنهم بشكل مبرمج يعني ثم
+
+130
+00:10:14,630 --> 00:10:18,590
+بعد ذلك كيف نعمل عملية التحليل تحليل المعرفة هذه
+
+131
+00:10:18,590 --> 00:10:23,040
+من أجل اتخاذ القرار لأن كل العمليةعملية اتخاذ قرار
+
+132
+00:10:23,040 --> 00:10:27,000
+يعني ال express system يتعرض عليه حالة بموافقات
+
+133
+00:10:27,000 --> 00:10:31,960
+معينة و هو يتخذ قرار انه هدى نتعامل معاه هيك او
+
+134
+00:10:31,960 --> 00:10:36,760
+نتعامل معاه هيك فالقالية
+
+135
+00:10:36,760 --> 00:10:39,920
+من قليات بناء ال express systems اللي هي انه احنا
+
+136
+00:10:39,920 --> 00:10:44,940
+نعبر عن المعرفة على شكل rules ال rule يعني if then
+
+137
+00:10:44,940 --> 00:10:49,360
+مظبوط فاحنا الآن لو طلعنا على السريع على أنماط من
+
+138
+00:10:49,360 --> 00:10:54,020
+ال rulesزي هنا مثلا مش عارف الشاشة واضحة ولا لا
+
+139
+00:10:54,020 --> 00:11:02,900
+خلّيني أكبر ال .. و أعمل full screen تمام؟ control
+
+140
+00:11:02,900 --> 00:11:10,440
+L اه control L okay هذه عبارة عنقول if the traffic
+
+141
+00:11:10,440 --> 00:11:15,540
+light is green يبجي ال action انه to go if the
+
+142
+00:11:15,540 --> 00:11:18,720
+traffic light is red then the action is stop تمام؟
+
+143
+00:11:18,910 --> 00:11:21,690
+أحيانا ال words بتبقى معقدة بمعنى أنه ممكن يبقى
+
+144
+00:11:21,690 --> 00:11:26,410
+فيها أكتر من condition if كده and كده and مش عارف
+
+145
+00:11:26,410 --> 00:11:31,130
+شوف بعدها then أجزاء تبع الشرط مش عارف إن عندي if
+
+146
+00:11:31,130 --> 00:11:35,590
+then اللي قبل then هذا الشرط وthen ليش ال
+
+147
+00:11:35,590 --> 00:11:38,310
+conclusion أقعد أقول أحنا ممكن نسميهم antecedence
+
+148
+00:11:38,310 --> 00:11:42,850
+antecedence اللي هو أجزاء الشرط سواء كان جزء واحد
+
+149
+00:11:42,850 --> 00:11:46,630
+أو multiple وال conclusion نسميها consequence
+
+150
+00:11:50,900 --> 00:11:54,560
+consequence الان فى أنواع من ال rules فى rules
+
+151
+00:11:54,560 --> 00:11:57,320
+بتعبر عن relation فى rules بتعبر عن recommendation
+
+152
+00:11:57,320 --> 00:12:00,660
+فى rules بتعبر عن directive هنرجعلهم هذا الأمور بس
+
+153
+00:12:00,660 --> 00:12:05,060
+أنا بمعنى بإن أفهم البنية تبع ال express system
+
+154
+00:12:05,060 --> 00:12:10,260
+اللى ال rules لسه جزء من أجزاها فالبنية أو ال
+
+155
+00:12:10,260 --> 00:12:10,840
+structure
+
+156
+00:12:14,090 --> 00:12:17,710
+أنا بانتقل إلى ال structure هاي ال structure of a
+
+157
+00:12:17,710 --> 00:12:21,970
+rule based system جاية بال .. بالتبسيط هذا يعني
+
+158
+00:12:21,970 --> 00:12:27,350
+تبسيط لل production system يعني هنا في عندي memory
+
+159
+00:12:27,350 --> 00:12:31,750
+ال memory هذه هي اللي بتتخزن ال knowledge المعرفة
+
+160
+00:12:31,750 --> 00:12:36,950
+ال knowledge تتخزن بصيغة ال rules يعني احنا لما
+
+161
+00:12:36,950 --> 00:12:42,350
+بنقول if a traffic light is red then stopهذه معرفة
+
+162
+00:12:42,350 --> 00:12:45,170
+احنا بنعلمها للولادة الصغيرة و بصرا احنا بعد هيك
+
+163
+00:12:45,170 --> 00:12:50,010
+عارفينها تلقائيا بس احنا يعني انه .. انه اذا الضوء
+
+164
+00:12:50,010 --> 00:12:55,510
+أحمر ايجا فهذه عبرنا عنها على شكل rule و ده كل ال
+
+165
+00:12:55,510 --> 00:13:00,870
+knowledge و الخبرة تبع ال human expert بانصيغة على
+
+166
+00:13:00,870 --> 00:13:04,310
+شكل rules ف .. و بنحطها في ليش؟ في ال long term
+
+167
+00:13:04,310 --> 00:13:08,790
+memoryهذا أول مكوّن من مكونات ال Express System
+
+168
+00:13:08,790 --> 00:13:13,390
+إضافة إلى ذلك يجب أن يكون لدي موري تانية Short
+
+169
+00:13:13,390 --> 00:13:17,970
+Term Memory اللي هي معطيات الحالة اللي سيستم
+
+170
+00:13:17,970 --> 00:13:23,290
+يتعامل معها سيستم يقول فلان لفلان حالته عنده حالة
+
+171
+00:13:23,290 --> 00:13:28,970
+مرضية و أعراضه كذا و كذا و كذا هذه المعطيات تنحط
+
+172
+00:13:28,970 --> 00:13:34,240
+في Short Term Memory بينما العلمالتشخيص والأمراض
+
+173
+00:13:34,240 --> 00:13:39,080
+وكيف تكون موجودة محبرة عنها في rules وين في ال
+
+174
+00:13:39,080 --> 00:13:44,620
+long term memory العنصر
+
+175
+00:13:44,620 --> 00:13:48,660
+الأساسي من عناصر ال expert system اللي هو ال
+
+176
+00:13:48,660 --> 00:13:51,240
+reasoning أو ال inference engine
+
+177
+00:13:56,270 --> 00:13:59,190
+ماشي يعني inference؟ inference جاي من to infer
+
+178
+00:13:59,190 --> 00:14:04,150
+infer يعني استنبط، نستنبط احنا استنتاج بناء على
+
+179
+00:14:04,150 --> 00:14:07,670
+المواضيع أو بناء على الحقائق ال inference مش
+
+180
+00:14:07,670 --> 00:14:12,790
+interference inference to infer ماشي معناته ان
+
+181
+00:14:12,790 --> 00:14:17,880
+احنا نستنبط conclusions بناء على المواضيعوهذه هي
+
+182
+00:14:17,880 --> 00:14:21,680
+ال engine أو ال component أساسي لل system Express
+
+183
+00:14:21,680 --> 00:14:28,900
+نرى كيف تعمل الفكرة ال inference engine ببساطة
+
+184
+00:14:28,900 --> 00:14:33,440
+شديدة بعد ذلك ال inference engine هو اللي يطلع ال
+
+185
+00:14:33,440 --> 00:14:38,260
+conclusion يعني هو بعتمد على ال long term memory
+
+186
+00:14:38,260 --> 00:14:41,800
+مع ال facts تبع ال short term memory عشان يعطيني
+
+187
+00:14:41,800 --> 00:14:44,120
+ال conclusion اللي أنا ببحث عنها
+
+188
+00:14:47,790 --> 00:14:53,180
+تمام هذه كانت ايش يعني تبسيط شديدممكن بضبط ندخل
+
+189
+00:14:53,180 --> 00:14:57,400
+عناصر أخرى على ال structure اللي هي انه ممكن انا
+
+190
+00:14:57,400 --> 00:15:00,940
+اضيف حد اسمه user interface معناه ان هذا ال system
+
+191
+00:15:00,940 --> 00:15:04,120
+هو في نهاية الأمر is an application software
+
+192
+00:15:04,120 --> 00:15:07,000
+application صح؟ و ال software application هذا بده
+
+193
+00:15:07,000 --> 00:15:11,280
+interface عشان انا ك user اتعامل معها ال interface
+
+194
+00:15:11,280 --> 00:15:14,980
+يعني قد تكون graphical GUI يعني او قد تكون
+
+195
+00:15:14,980 --> 00:15:20,030
+dialogue based يعني كأني بتحاور معاهمواحد على تشات
+
+196
+00:15:20,030 --> 00:15:22,970
+و لا على كده بيسألني أسئلة وبتجاوب بيسألني وبتجاوب
+
+197
+00:15:22,970 --> 00:15:27,090
+بيسألني وبتجاوب إلى أن بعد هيك .. اه يعني افترض
+
+198
+00:15:27,090 --> 00:15:30,890
+انه مريض وعنده .. وبده .. وبيبحث عن التشكيس الصحيح
+
+199
+00:15:30,890 --> 00:15:34,790
+لحالته فال system بيجي بيقوله اول سؤال مثلا ايش
+
+200
+00:15:34,790 --> 00:15:38,190
+بتشكي فبقوله باشكي من كده بقوله ايش كمان باشكي من
+
+201
+00:15:38,190 --> 00:15:41,590
+كده وكده هذه الأسئلة اللي هو بيسأله فيها بناء على
+
+202
+00:15:41,590 --> 00:15:47,920
+ال inference engine شو قاعدبيحلل في الموضوع فكل ما
+
+203
+00:15:47,920 --> 00:15:51,720
+يحتاج قطرة معلومة بيسأل ال user عنه هنا بتكون ال
+
+204
+00:15:51,720 --> 00:15:54,640
+interface او ال interaction ما بين ال system و ما
+
+205
+00:15:54,640 --> 00:15:57,540
+بين ال user عبارة عن dialogue based ممكن زي ما قلت
+
+206
+00:15:57,540 --> 00:16:02,040
+انا ال cash GUI form بتعب فيها كل المعطلات اللي
+
+207
+00:16:02,040 --> 00:16:05,470
+عندك و تضغط زر و هو بيعطيك cashبيعطيك ال
+
+208
+00:16:05,470 --> 00:16:08,650
+conclusion او ال decision مرة واحدة او بلاش
+
+209
+00:16:08,650 --> 00:16:11,870
+decision واحدة ممكن يعطيك alternatives ويقولك افضل
+
+210
+00:16:11,870 --> 00:16:14,830
+اشي كده اللي بعده كده اللي بعده كده تمام بدائل
+
+211
+00:16:14,830 --> 00:16:18,410
+يعني من ال conclusions فهذا واضح ليش ان احنا ممكن
+
+212
+00:16:18,410 --> 00:16:22,010
+نحتاج user interface هذا شي طبيعي جدا ممكن ايضا
+
+213
+00:16:22,010 --> 00:16:25,030
+كمان نحتاج ال explanation facility جزئية من ال
+
+214
+00:16:25,030 --> 00:16:30,810
+system اللي ال user اذا احتاج او طلب انه okay انت
+
+215
+00:16:31,490 --> 00:16:36,110
+عطيتني ال conclusion طيب فسرلي كيف وصلت لها ال
+
+216
+00:16:36,110 --> 00:16:41,150
+user يطلب من ال system تفسير كيف هو وصل إلى ان هذا
+
+217
+00:16:41,150 --> 00:16:45,130
+ال decision هو الأنسب او هذا قرار هو الأنسب فلازم
+
+218
+00:16:45,130 --> 00:16:52,760
+يبدأ في module جزئية من ال system اللي تتسجلخطوات
+
+219
+00:16:52,760 --> 00:16:58,140
+ال inference كيف تمت علشان لما يطلب ال user يطلب
+
+220
+00:16:58,140 --> 00:17:01,460
+explanation هذا ال explanation facility تعرضله
+
+221
+00:17:01,460 --> 00:17:05,680
+التسلسل المنطقي لكيف تم التوصل الى ال conclusion
+
+222
+00:17:05,680 --> 00:17:09,560
+واضح ايش يعني explanation facility و facilities
+
+223
+00:17:09,560 --> 00:17:18,460
+تمام تمام فهذه هي ال .. بص .. ممكن بقول كمان احنا
+
+224
+00:17:18,460 --> 00:17:25,210
+ايشممكن كمان انمسى في ال structure حيث انه هنا ال
+
+225
+00:17:25,210 --> 00:17:29,110
+interface نجسمها إلى جسمين نقول user interface
+
+226
+00:17:29,110 --> 00:17:34,150
+ونقول developer interface ايش هتفرج ال developer
+
+227
+00:17:34,150 --> 00:17:40,630
+interface عن اختصاصك اكتر اختصاصا او اقل اختصاصا
+
+228
+00:17:40,630 --> 00:17:44,050
+هذا اسمه user interface ال user يعني ال end user
+
+229
+00:17:44,050 --> 00:17:48,370
+الشخص المستفيد من قدرات هذا ال systemبس ال
+
+230
+00:17:48,370 --> 00:17:52,290
+developer هنا هو عبارة عن الشخص اللي بيساهم في
+
+231
+00:17:52,290 --> 00:17:56,670
+بناء ال systemبس هنا .. ايوة ال developer
+
+232
+00:17:56,670 --> 00:18:00,850
+interface هنا يقصد بيها ال knowledge engineer اللي
+
+233
+00:18:00,850 --> 00:18:05,830
+بيحط ال rules و بيعدل عليها لأن ال system مقدرش
+
+234
+00:18:05,830 --> 00:18:09,310
+نتوقع انه يغلق على مجموعة من ال rules اللي انحطت
+
+235
+00:18:09,310 --> 00:18:12,590
+فيه من البداية و خلاص لأ لازم يصير فيه نوع من ال
+
+236
+00:18:12,590 --> 00:18:16,130
+learning او ال development على ال knowledge تبعته
+
+237
+00:18:16,130 --> 00:18:20,790
+فبيجي human expert او بيجي knowledge engineer
+
+238
+00:18:20,790 --> 00:18:27,090
+بيغذي ال system ب newالحقائق عن حالته الـ facts هي
+
+239
+00:18:27,090 --> 00:18:33,110
+الuser اللي بيعطي الحقائق عن حالته ال developer ال
+
+240
+00:18:33,110 --> 00:18:35,710
+knowledge engineer و ال expert بيستخدموا ال
+
+241
+00:18:35,710 --> 00:18:41,600
+developer interface علشانيغذي الـ system بـ more
+
+242
+00:18:41,600 --> 00:18:44,760
+knowledge كذلك هذا الـ system يمكن يأخذ more
+
+243
+00:18:44,760 --> 00:18:48,580
+knowledge و more data من other sources غير هذوله
+
+244
+00:18:48,580 --> 00:18:52,740
+يعني هو يبقى مربوط بشكل أو باخر مع other databases
+
+245
+00:18:52,740 --> 00:18:57,140
+يعمل نوع من collection لـ knowledge تلقائيا من
+
+246
+00:18:57,140 --> 00:19:02,620
+نفسه يعني ممكن يتعمل فيه آليات لجمع المعلومات بشكل
+
+247
+00:19:02,620 --> 00:19:08,030
+أو باخر يجيبها هو من مصادر خارجيةأحنا الآن تدرجنا
+
+248
+00:19:08,030 --> 00:19:15,690
+في فهم ال structure تبع ال
+
+249
+00:19:15,690 --> 00:19:20,990
+express system دلنا
+
+250
+00:19:20,990 --> 00:19:25,870
+الآن ندخل على ال core component تبع ال express
+
+251
+00:19:25,870 --> 00:19:28,610
+system اللي هو ال inference engine اللي هو بيقدّي
+
+252
+00:19:28,610 --> 00:19:33,130
+الشغل الأساسي اللي هو بيستنقط بيحلل المعطيات وال
+
+253
+00:19:33,130 --> 00:19:37,920
+knowledge عشانيخرج بـ Conclusion اللي هو ال
+
+254
+00:19:37,920 --> 00:19:42,320
+inference engine inference engine بيشتغل بقالية
+
+255
+00:19:42,320 --> 00:19:47,460
+اسمها forward chaining و أحيانا ممكن backward بس
+
+256
+00:19:47,460 --> 00:19:51,600
+نفهم ال forward تتضح إيش يعني ال backward بسيطة
+
+257
+00:19:51,600 --> 00:19:56,660
+جدا قاليته بسيطة جدا قالية عمل ال inference engine
+
+258
+00:19:56,660 --> 00:20:01,700
+ال inference engine بسيطة لأنها عبارة عن cycles
+
+259
+00:20:02,650 --> 00:20:08,990
+دورات نفسها هي هي بتتكرر عند ال database ال
+
+260
+00:20:08,990 --> 00:20:18,490
+database فيها facts تمام هذه short term memory وفي
+
+261
+00:20:18,490 --> 00:20:22,810
+عنده knowledge base اللي هي long term memory هذه
+
+262
+00:20:22,810 --> 00:20:28,730
+فيها facts قام ال user بتقديتها وهذه فيها rules
+
+263
+00:20:28,730 --> 00:20:31,230
+قام ال expert أو knowledge engineer
+
+264
+00:20:34,810 --> 00:20:39,690
+بهدف بتغييرته ببساطة شديدة هذه انتي انا هنا ال
+
+265
+00:20:39,690 --> 00:20:44,370
+rule ال rule فيها antecedent اللي هو ال condition
+
+266
+00:20:44,370 --> 00:20:49,610
+وفيها conclusion وظيفة
+
+267
+00:20:49,610 --> 00:20:53,430
+ال inference engine في كل cycle يبحث في ال memory
+
+268
+00:20:53,430 --> 00:20:57,630
+اللي هو شرط ال memory في ال database عن اي fact
+
+269
+00:20:57,630 --> 00:21:05,010
+يمكن انه يتحقق اي شرط من الشروطإذا تبقى تبقى ال
+
+270
+00:21:05,010 --> 00:21:08,670
+rules إذا فيه rule الشرط تبقى هتتحقق إيش هتتحقق
+
+271
+00:21:08,670 --> 00:21:15,430
+يعني في fact موجودة بتبطيه يبقى أنا برضه أستدج إنه
+
+272
+00:21:15,430 --> 00:21:22,050
+ال conclusion تبعته أصبحت fact ولا لأ يعني أنا أنا
+
+273
+00:21:22,050 --> 00:21:27,490
+المفروض إذا a is x إذا في عندي متغير اسمه a وقيمته
+
+274
+00:21:27,490 --> 00:21:31,870
+x إذا هذا الكلام صحيح إذا هذا الكلام صحيح فمعنى
+
+275
+00:21:32,080 --> 00:21:36,500
+معنى ذلك بقدر استنتج أن P قيمة Y هذا الكلام لم أكن
+
+276
+00:21:36,500 --> 00:21:40,320
+أعرف إذا كان صحيح أو ليس صحيح إلا إذا وجدت في ال
+
+277
+00:21:40,320 --> 00:21:46,460
+fact حاجة تقول إن فعلًا نعم A قيمة X إذا هذا
+
+278
+00:21:46,460 --> 00:21:50,320
+الكلام معطى معنى ذلك أن هذا ال rule تحققت معنى ذلك
+
+279
+00:21:50,320 --> 00:21:54,420
+أن هذا ال conclusion أصبحت حقيقة مصبوط و واقع
+
+280
+00:21:54,420 --> 00:21:59,540
+فبقدر أمسك هذه و أضيفها ك cash ك fact في ال memory
+
+281
+00:21:59,540 --> 00:22:04,050
+short termصار عندي shorter memo لان فيها معلومة
+
+282
+00:22:04,050 --> 00:22:10,890
+جديدة بعيد تاني .. بعيد تاني ال cycle و بقى اشوف
+
+283
+00:22:10,890 --> 00:22:15,770
+هذه الجديدة و ايضا الجديمة هذه ال facts الجديمة هل
+
+284
+00:22:15,770 --> 00:22:22,030
+اصبح لان في rules أخرى ممكن أستنبط
+
+285
+00:22:22,030 --> 00:22:27,130
+ال conclusion تبعتها بيتم العمل هذا دورة و ر دورة
+
+286
+00:22:27,130 --> 00:22:29,690
+إلى أن اصل إلى
+
+287
+00:22:31,880 --> 00:22:36,160
+conclusion بتجاوب على السؤال اللي انا بديها بتجاوب
+
+288
+00:22:36,160 --> 00:22:39,660
+على السؤال اللي انا بديها خلاني اطلع مثلا على ال
+
+289
+00:22:39,660 --> 00:22:43,080
+example
+
+290
+00:22:43,080 --> 00:22:51,500
+هنا انا approved تلاتة rules تمام انا الان هدفي ان
+
+291
+00:22:51,500 --> 00:23:00,290
+اصل الى قيمة ال z قيمة ال ايش ال zهل هي true ولا
+
+292
+00:23:00,290 --> 00:23:04,690
+false؟ بدي أعرف بس بناء على إيش بدي أعرف؟ بناء على
+
+293
+00:23:04,690 --> 00:23:08,530
+المواضيع اللي لدي حسب ال rules حسب المواضيع وحسب
+
+294
+00:23:08,530 --> 00:23:11,910
+ال rules ال rules لحالها أنا مابقدر أشغلها أو
+
+295
+00:23:11,910 --> 00:23:16,830
+أصنبط منها إلا بناء على ال data على facts okay
+
+296
+00:23:16,830 --> 00:23:22,910
+فالأن زيادة عشان أعرف الكلب true ولا false لازم
+
+297
+00:23:22,910 --> 00:23:28,610
+أطلع على مين؟ على Y و D من وين هذا الكلب أجاه؟أجل
+
+298
+00:23:28,610 --> 00:23:34,810
+لأن هنا في rule رقم واحد بتقول if y is true and d
+
+299
+00:23:34,810 --> 00:23:39,290
+is true يبقى z is true طب انا الآن صار بدي أعرف ال
+
+300
+00:23:39,290 --> 00:23:42,570
+y و ال d هدولة true ولا false لازم أشوف ال y لحالة
+
+301
+00:23:42,570 --> 00:23:47,430
+و أشوف ال d لحالةالان عشان انا .. ال D .. ال D
+
+302
+00:23:47,430 --> 00:23:51,070
+مافيش rule .. مافيش rule بتقول اذا كذا كذا then D
+
+303
+00:23:51,070 --> 00:23:55,770
+كده كده يعني هذا يجب تعطيلي ك fact يعني لازم انا
+
+304
+00:23:55,770 --> 00:23:59,910
+اسم .. لأ لازم ال system يسأل ال user عنها يقوله
+
+305
+00:23:59,910 --> 00:24:04,730
+هل D إيش وضع D هل هي true ولا false تمام؟ اللي انا
+
+306
+00:24:04,730 --> 00:24:08,750
+بدي أعرف ال why مازال فيه rule بتصب فيها بسألش
+
+307
+00:24:08,750 --> 00:24:15,640
+وراح نشوف ال rule okay تمام؟ بتبدي نطلع علىالعناصر
+
+308
+00:24:15,640 --> 00:24:22,100
+تبعتها ال X والB والE هؤلاء لازم ياخدهم ال user
+
+309
+00:24:22,100 --> 00:24:28,380
+هادي بيستنبطها القيمة X من قيمة A من أين هذا
+
+310
+00:24:28,380 --> 00:24:31,400
+الكلام أجا من هذا اجا من هذا اقول if A is true
+
+311
+00:24:31,400 --> 00:24:36,680
+then X is true انا عمليا الان اللي حكيته مش
+
+312
+00:24:36,680 --> 00:24:39,740
+forward chaining هو backward chaining أنا جيت من
+
+313
+00:24:39,740 --> 00:24:43,570
+ال Z ورجعت رجوعبينما الكلام اللي كنا بنحكي فيه في
+
+314
+00:24:43,570 --> 00:24:48,110
+الأول ان انا لأ ان انا ببدأ من اللي مابه ماشي يعني
+
+315
+00:24:48,110 --> 00:24:53,230
+لازم اكون عندي ال a قيمتها معلومة و ال b قيمتها
+
+316
+00:24:53,230 --> 00:24:58,870
+معلومة و ال e قيمتها معلومة و ال h و ال d قيمتها
+
+317
+00:24:58,870 --> 00:25:04,570
+معلومة الآن بأمسك ال rules تبعتي واحدة و لا تانية
+
+318
+00:25:04,570 --> 00:25:07,030
+هذا ال expert system ال inference engine بمسك ال
+
+319
+00:25:07,030 --> 00:25:11,650
+rules بيقول ال rule رقم واحدإيش الشرط تبعها Y وD
+
+320
+00:25:11,650 --> 00:25:20,250
+هل في عندي هنا إشي يغطي الشرط هذا عند ال D بكل
+
+321
+00:25:20,250 --> 00:25:25,650
+user مدخلها بس ال Y مابعرفش يبجي هذا ال rule الشرط
+
+322
+00:25:25,650 --> 00:25:32,190
+تبعها مش معروف مش معروف صحته من عدمه هذا في ال
+
+323
+00:25:32,190 --> 00:25:36,530
+forwardفي ال forward أنا ببدأ من ال rules ببدأ من
+
+324
+00:25:36,530 --> 00:25:40,590
+الحقائق اللي معايا وبشوف من من ال rules الشرط
+
+325
+00:25:40,590 --> 00:25:47,250
+تبعها فيه هناك ما يسنده من الحقائق إذا واحدة من ال
+
+326
+00:25:47,250 --> 00:25:51,750
+rules الشرط تبعها فيه حقائق بتسنده معناه ذلك اللي
+
+327
+00:25:51,750 --> 00:25:56,050
+بنقول ان ال rule is fires fire يعني كإني أنا ضغطت
+
+328
+00:25:56,050 --> 00:26:02,040
+زناد البندقية أو المسدسمتى ال rule fires لما ال
+
+329
+00:26:02,040 --> 00:26:06,220
+condition تبعها بيكون فيه ياندي معطيات بتسنده؟ إذا
+
+330
+00:26:06,220 --> 00:26:08,920
+في معطيات بتسنده، معناة ال rule fires إيش معناة
+
+331
+00:26:08,920 --> 00:26:12,540
+fires؟ يعني إيش اللي بينتج عن ذلك؟ بينتج عن ذلك إن
+
+332
+00:26:12,540 --> 00:26:16,980
+ال conclusion تبعتها بتصبح معلومة، تمام؟ أنا الآن
+
+333
+00:26:16,980 --> 00:26:20,720
+أفترض إن هذا معروف و هذا معروف و هذا معروف، مين من
+
+334
+00:26:20,720 --> 00:26:26,120
+ال rules هدولة الآن ممكن
+
+335
+00:26:26,120 --> 00:26:31,270
+to fire؟ أفترض إن هدولة معروفينال rule هذه بنزمها
+
+336
+00:26:31,270 --> 00:26:36,490
+ال y و ال d عند ال d بس ماعنديش ال y بقدرش to fire
+
+337
+00:26:36,490 --> 00:26:41,870
+هذا ال rule هذه بده ال x و بده ال b و بده ال e ال
+
+338
+00:26:41,870 --> 00:26:45,310
+b و ال e موجودة بس ال x مش موجودة بينما هذه بده بس
+
+339
+00:26:45,310 --> 00:26:49,890
+ال a و ال a موجودة يعني هذا ال rule fires fire
+
+340
+00:26:49,890 --> 00:26:56,550
+يعني ال conclusion بتتحقق تتحقق يعني x is true بس
+
+341
+00:26:56,550 --> 00:27:02,980
+يا راني معلومة جديدة هتنبع في وين هذه الكلامعلى ال
+
+342
+00:27:02,980 --> 00:27:13,520
+facts اللي هي short term memory طيب الآن صارت X
+
+343
+00:27:13,520 --> 00:27:19,760
+معلومة in the trueخلصنا احنا ال cycle الأولى
+
+344
+00:27:19,760 --> 00:27:23,620
+ففرّينا على ال rules كلها لمّا واحدة منهم fired
+
+345
+00:27:23,620 --> 00:27:30,540
+فنفّذناها ورجعنا تاني cycle جديد ال cycle الجديد
+
+346
+00:27:30,540 --> 00:27:34,380
+نمر عليهم نار بنفس الترتيب ال rule الأولى هل can
+
+347
+00:27:34,380 --> 00:27:38,820
+be fired لسه لأن ال why لسه مش معلومة هذه عند ال E
+
+348
+00:27:38,820 --> 00:27:41,580
+وعند ال B وعندي أصلها عند ال X يبقى fires يبقى
+
+349
+00:27:41,580 --> 00:27:46,360
+الان firing ال rule رقم 2 معناه ناشط ال conclusion
+
+350
+00:27:46,360 --> 00:27:52,720
+تبعتهاwill be activated يعني سيكون صحيح فالـ C and
+
+351
+00:27:52,720 --> 00:28:00,920
+Y تسجل و القيمة تبعتها خلاص
+
+352
+00:28:00,920 --> 00:28:05,540
+مجرد أن واحد من ال rules fires خلاص بنهي ال cycle
+
+353
+00:28:05,540 --> 00:28:08,900
+و بابت cycle جديد بانفذش اكتر من ال rule في ال
+
+354
+00:28:08,900 --> 00:28:17,940
+cycle نفسها بدأنا جديد الآن ف .. فإيش؟صار في اندي
+
+355
+00:28:17,940 --> 00:28:22,960
+ال y موجودة و ال d موجودة فبقدر اد ال rule لان
+
+356
+00:28:22,960 --> 00:28:29,380
+تتطبق و بعرف ال z الآن ال z بناء على ال example
+
+357
+00:28:29,380 --> 00:28:33,900
+هذه ال z هي ال goal تبعي هي المتغير اللي انا بدي
+
+358
+00:28:33,900 --> 00:28:39,920
+اعرف قيمته فخلاص علمت القيمة تبعته طبعا كيف علمت
+
+359
+00:28:39,920 --> 00:28:45,660
+القيمة نفدت ال rule ايش نفدت صارت zموجود عندى فى
+
+360
+00:28:45,660 --> 00:28:49,960
+ال short term memory و القيمة تبعتها معروفة فيبقى
+
+361
+00:28:49,960 --> 00:28:54,700
+وين ال termination condition لها ال cycle هى دى ال
+
+362
+00:28:54,700 --> 00:28:56,480
+termination condition ايش يعني termination
+
+363
+00:28:56,480 --> 00:29:02,880
+condition يعني شط ايقاف الدوران هذا اللى هو انه ال
+
+364
+00:29:02,880 --> 00:29:06,860
+goal تبعتى يصبح موجود فى ال short term memory اذا
+
+365
+00:29:06,860 --> 00:29:11,420
+وجه ال goal فى ال short term memory بنجف و بنعطيه
+
+366
+00:29:11,420 --> 00:29:12,700
+القيمة تبعته
+
+367
+00:29:16,500 --> 00:29:20,620
+ما هو هو هنا في المثال هذا السؤال تبعنا ما هي الـ
+
+368
+00:29:20,620 --> 00:29:24,000
+Boolean value أو ال truth value تبع ال Z هل هو ال
+
+369
+00:29:24,000 --> 00:29:27,320
+false ولا ال true؟ ماشي احنا هذا اللي بنعرفه،
+
+370
+00:29:27,320 --> 00:29:31,460
+بنعرف إنه true ولا false، مش بدنا يكون true، احنا
+
+371
+00:29:31,460 --> 00:29:35,440
+بنعرف بناء على الموقعات اللي متوفرة معانا من
+
+372
+00:29:35,440 --> 00:29:40,090
+البداية، هل ال Z موقعها true ولا false؟ تمام؟يعني
+
+373
+00:29:40,090 --> 00:29:44,870
+مثلا ممكن اعطيك مسألة ان والله بدنا نعرف فلان
+
+374
+00:29:44,870 --> 00:29:48,130
+لفلان هل هو موجود الان المدرس الفلاني موجود الان
+
+375
+00:29:48,130 --> 00:29:51,450
+في مكتبه ولا لأ تمام؟ بدناش نروح المكتب و ندق
+
+376
+00:29:51,450 --> 00:29:55,070
+الباب و نشوف بس بدنا ناخد معطيات نفترض ان في
+
+377
+00:29:55,070 --> 00:29:59,730
+معطيات ممكن نستند اليها فبصير المسألة هي هل موجود
+
+378
+00:29:59,730 --> 00:30:04,810
+في مكانه ولا لأ اه بناء على المعطيات بتتحللوبناء
+
+379
+00:30:04,810 --> 00:30:08,430
+على ال rules والله إذا كان .. إذا كان الساعة من
+
+380
+00:30:08,430 --> 00:30:12,790
+كده لكده فهو ماعندوش محاضرة طيب عندوش محاضرة هل
+
+381
+00:30:12,790 --> 00:30:16,530
+معناه ذلك إن هو في المكتب؟ لأ إذا والله عنده ..
+
+382
+00:30:16,530 --> 00:30:20,010
+ففيبقى في مجموعة من ال rules ومجموعة بسيطة من
+
+383
+00:30:20,010 --> 00:30:24,350
+الحقائق على أساسها بيتم استنباط أو inferring ال
+
+384
+00:30:24,350 --> 00:30:27,590
+إيش ال conclusion اللي هي اللي هي هو موجود في
+
+385
+00:30:27,590 --> 00:30:31,070
+المكتب ولا مش موجود طبعا فاحنا الآن يفترض ووضحت
+
+386
+00:30:31,070 --> 00:30:37,620
+عندنا آلية ال إيشقالية عمل مرة تانية قالية عمل ال
+
+387
+00:30:37,620 --> 00:30:41,960
+inference engine هي عبارة عن ال cycles match fire
+
+388
+00:30:41,960 --> 00:30:46,700
+procedure match cycles of match fire match يعني
+
+389
+00:30:46,700 --> 00:30:50,300
+بنطابق المطالبات اللي موجودة في ال short term
+
+390
+00:30:50,300 --> 00:30:53,700
+memory أو في ال database المحطتها مع إيش بنطابقها
+
+391
+00:30:53,700 --> 00:30:58,220
+مع إيش أو بنبحث عنها في إيش في ال conditions تبع
+
+392
+00:30:58,220 --> 00:31:01,580
+ال rules إذا لجينا ال rule ال condition تبعها
+
+393
+00:31:01,580 --> 00:31:08,490
+كاملامطابق بيه ال facts يبقى هذا ال rule ماشي
+
+394
+00:31:08,490 --> 00:31:13,230
+fires fires يعني ال conclusion تبعتها تصبح حقيقة
+
+395
+00:31:13,230 --> 00:31:17,670
+تضاف إلى ال short term memory و بنكرر و بنكرر إلى
+
+396
+00:31:17,670 --> 00:31:24,650
+أن ال cycle تستمر إلى أن المتغير اللي احنا بنبحث
+
+397
+00:31:24,650 --> 00:31:29,910
+عنه يصبح موجود في ال short term هذا ال forward
+
+398
+00:31:29,910 --> 00:31:35,410
+changingهذه الـ slide بتوضح نفس المثال اللي حكيناه
+
+399
+00:31:35,410 --> 00:31:41,090
+فيه Cycle Cycle Cycle Cycle Cycle Cycle Cycle
+
+400
+00:31:41,090 --> 00:31:41,430
+Cycle Cycle Cycle Cycle Cycle Cycle Cycle Cycle
+
+401
+00:31:41,430 --> 00:31:42,530
+Cycle Cycle Cycle Cycle Cycle Cycle Cycle Cycle
+
+402
+00:31:42,530 --> 00:31:42,530
+Cycle Cycle Cycle Cycle Cycle Cycle Cycle Cycle
+
+403
+00:31:42,530 --> 00:31:42,530
+Cycle Cycle Cycle Cycle Cycle Cycle Cycle Cycle
+
+404
+00:31:42,530 --> 00:31:42,530
+Cycle Cycle Cycle Cycle Cycle Cycle Cycle Cycle
+
+405
+00:31:42,530 --> 00:31:42,950
+Cycle Cycle Cycle Cycle Cycle Cycle Cycle Cycle
+
+406
+00:31:42,950 --> 00:31:42,950
+Cycle Cycle Cycle Cycle Cycle Cycle Cycle Cycle
+
+407
+00:31:42,950 --> 00:31:42,950
+Cycle Cycle Cycle Cycle Cycle Cycle Cycle Cycle
+
+408
+00:31:42,950 --> 00:31:42,950
+Cycle Cycle Cycle Cycle Cycle Cycle Cycle Cycle
+
+409
+00:31:42,950 --> 00:31:43,030
+Cycle Cycle Cycle Cycle Cycle Cycle Cycle Cycle
+
+410
+00:31:43,030 --> 00:31:43,030
+Cycle Cycle Cycle Cycle Cycle Cycle Cycle Cycle
+
+411
+00:31:43,030 --> 00:31:54,190
+Cycle Cycle Cycle Cycle Cycle
+
+412
+00:31:54,190 --> 00:31:57,210
+Cy
+
+413
+00:32:02,720 --> 00:32:10,160
+هذا هو قيمته بحث الآن برضه في ال rules ولكن بطلع
+
+414
+00:32:10,160 --> 00:32:14,480
+مش على ال condition بطلع على ال conclusion ببحث عن
+
+415
+00:32:14,480 --> 00:32:20,580
+مين من ال rules مين من ال rules ال conclusion
+
+416
+00:32:20,580 --> 00:32:27,460
+تبعتها مش ال true بتجيب سيرة ال variable اللي أنا
+
+417
+00:32:27,460 --> 00:32:30,760
+بدور عليه هل هذه بتجيب سيرة ال variable
+
+418
+00:32:34,060 --> 00:32:38,420
+هذه الأولى بس هي ليش اللى بتمكّدني أن أستنبط
+
+419
+00:32:38,420 --> 00:32:44,200
+القيمة تبع ال Z حلو مازال مازال هادى يبقى الآن أنا
+
+420
+00:32:44,200 --> 00:32:49,780
+بحب أخد ال condition تبعها و إيش بسوا فيه بعتبره
+
+421
+00:32:49,780 --> 00:32:54,780
+بهم الآن goals بصير أنا أبحث عن ال Y و عن ال D
+
+422
+00:32:54,780 --> 00:33:01,080
+ماشي الحال فبصير ألف بحث عن meaning of rules و
+
+423
+00:33:01,080 --> 00:33:06,730
+أجيب سيرة ال Y ال Y في الأول طبعاهذه طيب و حلوة
+
+424
+00:33:06,730 --> 00:33:10,150
+هذه بتقول لي قيمة ال Y ولكن مش طلع تقول لي ان في
+
+425
+00:33:10,150 --> 00:33:15,990
+عندي قيم ال X و ال B بيصير ناخدهم هم ك sub goals
+
+426
+00:33:15,990 --> 00:33:19,830
+فبتدرج انا من ال goal الأساسي اللي هو ال Z الى sub
+
+427
+00:33:19,830 --> 00:33:24,150
+goals اللي بتحدد
+
+428
+00:33:24,150 --> 00:33:28,410
+ليها ال rules هذا ايش اسمه هذا ال background؟
+
+429
+00:33:28,410 --> 00:33:33,580
+شوكات زي ايه قد سؤال المفروض ياطلر من D2بالظبط هو
+
+430
+00:33:33,580 --> 00:33:38,180
+لازم اي مسألة .. اي مسألة مابتقدرش انت او ال
+
+431
+00:33:38,180 --> 00:33:41,940
+system ايه يعالجها الا بناء على المعطيات لازم تبقى
+
+432
+00:33:41,940 --> 00:33:49,180
+توفر المعطيات صح او لا طيب احنا الان ايش بيبقى
+
+433
+00:33:49,180 --> 00:33:53,900
+نقدر نسوي في الواجهة ده خلينا نرخص بس الحكينات
+
+434
+00:33:53,900 --> 00:33:57,580
+احنا صبنا حكينا عن ال structure تبع ال rule based
+
+435
+00:33:57,580 --> 00:34:00,140
+express system انا بقول rule based express system
+
+436
+00:34:00,140 --> 00:34:02,940
+لأنه في انواع اخرى من ال express systemsما هيش
+
+437
+00:34:02,940 --> 00:34:06,900
+rule based زي ال case based مثلا بعدين حكينا عن ال
+
+438
+00:34:06,900 --> 00:34:10,420
+forward chaining و ال backward chaining دلنا نحكي
+
+439
+00:34:10,420 --> 00:34:13,300
+عن ال conflict resolution ال conflict resolution
+
+440
+00:34:13,300 --> 00:34:17,980
+اللي هو لما نكون في عندي أكتر من rule اه يعني
+
+441
+00:34:17,980 --> 00:34:20,880
+افترض ان احنا شغالين forward chaining forward
+
+442
+00:34:20,880 --> 00:34:25,600
+chaining و هنا انا دجيت ان ال rule اللي كنتش تبعها
+
+443
+00:34:25,600 --> 00:34:30,400
+و ال rule تاني برضه كنتش تبعها عملوا matching مش
+
+444
+00:34:30,400 --> 00:34:36,040
+هنعملوا matchingيعني الحقائق المتوفرة بتسند هذه
+
+445
+00:34:36,040 --> 00:34:41,000
+وبتسند هذهك اختار مين منهم هذا اسمه conflict two
+
+446
+00:34:41,000 --> 00:34:46,820
+rules متزاحمة على انه to be fired يعني to be
+
+447
+00:34:46,820 --> 00:34:50,480
+executed فأطبق مين منهم هذا الكلام نحكيه في
+
+448
+00:34:50,480 --> 00:34:54,740
+المحاضرة التالية فيه أكتر من رؤة يعني strategy ل
+
+449
+00:34:54,740 --> 00:34:58,710
+ال conflict resolutionو المحاضرة الجاية برضه بنكمل
+
+450
+00:34:58,710 --> 00:35:01,010
+الى قضية ال characteristics وما إلى ذلك ماشي
+
+451
+00:35:01,010 --> 00:35:01,610
+أعطيكم العافية
+
diff --git a/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/n65Hy5Nug48.srt b/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/n65Hy5Nug48.srt
new file mode 100644
index 0000000000000000000000000000000000000000..9686f4e42b373e0d2477551b51682b8f11c037dc
--- /dev/null
+++ b/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/n65Hy5Nug48.srt
@@ -0,0 +1,1432 @@
+1
+00:00:21,500 --> 00:00:24,320
+بسم الله الرحمن الرحيم، المحاضرة اليوم إن شاء الله
+
+2
+00:00:24,320 --> 00:00:27,960
+شغال في نفس موضوع الـ artificial neural networks بس
+
+3
+00:00:27,960 --> 00:00:31,900
+من اتحول إلى النوع الآخر من الـ neural networks
+
+4
+00:00:31,900 --> 00:00:36,740
+اللي هي اللي بتستخدم unsupervised learning، يعني
+
+5
+00:00:36,740 --> 00:00:40,820
+اللي في عندها آلية تعديل أوزان ذاتية
+
+6
+00:00:40,820 --> 00:00:46,360
+لتعديل الأوزان في الشق ده من الـ neural networks
+
+7
+00:00:46,360 --> 00:00:51,460
+بيطلع على نوعين أساسيين، اللي هما الـ Hebbian
+
+8
+00:00:51,460 --> 00:00:56,340
+networks وهيبيان و competitive learning
+
+9
+00:01:36,520 --> 00:01:39,820
+بتقدر تقول competitive networks و Hebian networks
+
+10
+00:01:39,820 --> 00:01:47,640
+بس بيبينوا اختلافات الـ unsupervised learning البدائية
+
+11
+00:01:47,640 --> 00:01:51,260
+أنا في الـ competitive learning لأنه شوية أبسط
+
+12
+00:01:51,260 --> 00:01:55,900
+وتلقائي، ممكن نستوعبه بسهولة، وبعدها كمان ننتقل على الـ
+
+13
+00:01:55,900 --> 00:01:58,920
+Hebian اللي هو برضه بسيط، بس يعني هذا أنا شايفه
+
+14
+00:01:58,920 --> 00:02:05,260
+مقدمة أو مدخل أبسط من الـ Hebian، فبدأ أروح على طول
+
+15
+00:02:05,260 --> 00:02:10,100
+على الـ competitive learning slides. competitive
+
+16
+00:02:10,100 --> 00:02:15,040
+learning. competitive الكلمة جاية من إنه فيه
+
+17
+00:02:15,040 --> 00:02:17,540
+competition، في نوع من الـ competition، يعني إيش
+
+18
+00:02:17,540 --> 00:02:21,520
+competition؟ سبق ما بين الـ nodes اللي في الـ
+
+19
+00:02:21,520 --> 00:02:32,560
+network. بساطة شديدة، لو أنا عندي network بسيطة
+
+20
+00:02:32,560 --> 00:02:36,490
+جداً زي هيك: input layer واحدة و output layer واحدة
+
+21
+00:02:36,490 --> 00:02:42,370
+طبعاً ما فيه hidden، وفيها الـ input بسيط جداً، الـ
+
+22
+00:02:42,370 --> 00:02:47,150
+input vector فيه two elements: x1 و x2. تذكروا مثال
+
+23
+00:02:47,150 --> 00:02:52,270
+الـ AND و الـ OR و الـ XOR، كان الـ input برضه فيه two
+
+24
+00:02:52,270 --> 00:02:56,870
+elements. الـ input vector هنا نفس الشيء، الـ output
+
+25
+00:02:56,870 --> 00:03:00,690
+layer فيها ثلاثة nodes. الـ input بتوزع على الثلاثة
+
+26
+00:03:00,690 --> 00:03:09,070
+nodes. طبعاً، هذه الآن بتوزع X1، الـ output بتوزع
+
+27
+00:03:09,070 --> 00:03:12,310
+إلى كل واحدة من الـ nodes، وهذه كل واحدة منها
+
+28
+00:03:12,310 --> 00:03:15,410
+فبالتالي كل واحدة من الـ nodes اللي بيجيها نسخة من
+
+29
+00:03:15,410 --> 00:03:20,290
+X1، نسخة من X2، X1، X2، صح؟ هذا الآن اللي أنا حاطيته
+
+30
+00:03:20,290 --> 00:03:23,670
+هنا في المستطيل، هذا عبارة عن input vector نفسه
+
+31
+00:03:23,670 --> 00:03:28,970
+اللي بينسكب عليه على ثلاثة output nodes، طبعاً كل واحد
+
+32
+00:03:28,970 --> 00:03:34,190
+من الـ output nodes هذه فيه weight، في وزن على الـ
+
+33
+00:03:34,190 --> 00:03:40,930
+input، صحيح؟ الوزن على الـ input، صحيح؟ قليلة العمل
+
+34
+00:03:40,930 --> 00:03:44,810
+تبع هذا الـ network بسيطة جداً، إنه أنت تتخيل هذا
+
+35
+00:03:44,810 --> 00:03:48,290
+عبارة عن input vector، وفي weight vector، weight
+
+36
+00:03:48,290 --> 00:03:53,230
+vector. هذا المربع المسطّح، هذا يعبر عن الأوزان، مش
+
+37
+00:03:53,230 --> 00:03:58,950
+عن الـ input نفسه. فكل node رقم واحد مثلاً، رقم اثنين،
+
+38
+00:03:58,950 --> 00:04:03,170
+رقم ثلاثة، الـ output تبعها، الـ output بقى للنود، و
+
+39
+00:04:03,170 --> 00:04:07,730
+عبارة عن حاصل ضرب الـ input vector في الـ weight
+
+40
+00:04:07,730 --> 00:04:15,370
+vector. ولا لأ؟ لسه فيه thresholding، نأخذ هذا ونعمله
+
+41
+00:04:15,370 --> 00:04:20,610
+ونعمله thresholding، وبعدين نأخذ الـ sign تبعه أو
+
+42
+00:04:20,610 --> 00:04:24,430
+الـ activation function تبعه. ولا لأ؟ إحنا ما نأخذش
+
+43
+00:04:24,430 --> 00:04:31,500
+حاصل الضرب ونطلع عليه على طول، مظبوط؟ نأخذ الـ
+
+44
+00:04:31,500 --> 00:04:37,460
+threshold وبنطلع الـ output. الآن في هذا النوع من
+
+45
+00:04:37,460 --> 00:04:42,020
+الـ networks، في هذا النوع من الـ networks إحنا لا
+
+46
+00:04:42,020 --> 00:04:48,280
+بنضرب ولا بنأخذ الـ threshold ولا أي من هذا الكلام.
+
+47
+00:04:48,280 --> 00:04:55,600
+إحنا اللي بنعمله، الـ node بتتعامل مع الـ two vectors
+
+48
+00:04:55,600 --> 00:04:59,920
+فقط.
+
+49
+00:04:59,920 --> 00:05:00,500
+شوية بس.
+
+50
+00:05:03,650 --> 00:05:13,630
+خليني أقف هنا. إيش الأسئلة؟ أقصد
+
+51
+00:05:13,630 --> 00:05:17,110
+الـ sign، أنا كنت بدأت أكتب كلمة الـ sign، تمام؟ هذا
+
+52
+00:05:17,110 --> 00:05:24,230
+الكلام كله الآن، حتى هذا الكلام، شو اللي هنتعامل
+
+53
+00:05:24,230 --> 00:05:27,370
+غيره؟ هناخد الـ two vectors هذول أو الـ node
+
+54
+00:05:30,390 --> 00:05:33,230
+بتاخد الـ two vectors دول، اللي هما الـ input و
+
+55
+00:05:33,230 --> 00:05:38,790
+الأوزان تبعها، وبنحسب الفرق ما بينهم، الفرق ما بين
+
+56
+00:05:38,790 --> 00:05:44,190
+الـ two vectors. إذا في عندي vector X فيها X1 و X2،
+
+57
+00:05:44,190 --> 00:05:52,310
+وعندي vector W فيها W1 و W2، إيش الفرق ما بين الـ two
+
+58
+00:05:52,310 --> 00:05:56,330
+vectors دول؟ بنعتبر إحنا إن الـ two vectors دول
+
+59
+00:05:56,330 --> 00:05:58,650
+على Cartesian plane، إيش على الـ Cartesian plane؟
+
+60
+00:06:02,640 --> 00:06:05,020
+انتبهوا إن الـ two vectors دول عبارة عن .. لأن هذا
+
+61
+00:06:05,020 --> 00:06:09,640
+two points، انتبهوا إنهم two points في الـ .. يعني
+
+62
+00:06:09,640 --> 00:06:12,920
+الـ X هذه عبارة عن point، و الـ W عبارة عن
+
+63
+00:06:12,920 --> 00:06:21,740
+point. الفرق ما بينهم هو الـ distance، المسافة. الفرق
+
+64
+00:06:21,740 --> 00:06:25,560
+ما بين الـ two vectors، الـ input vector و الـ weight
+
+65
+00:06:25,560 --> 00:06:29,000
+vector، بنأخذه على أساس إنه هو المسافة. إيش المسافة
+
+66
+00:06:29,000 --> 00:06:30,260
+في الـ Cartesian plane؟
+
+67
+00:06:35,920 --> 00:06:42,400
+كيف نحسب المسافة في الـ Cartesian plane؟ الـ
+
+68
+00:06:42,400 --> 00:06:47,240
+D هذه عبارة عن الـ distance، D1،
+
+69
+00:06:47,240 --> 00:06:52,500
+D2، D3، تتوقع على إيش كل node من الـ nodes one و two
+
+70
+00:06:52,500 --> 00:06:56,020
+و ثلاثة بتحسب الـ distance تبعتها؟ عشان الـ distance
+
+71
+00:06:56,020 --> 00:06:59,540
+تبعتها يعني الفرق ما بين عندي، وأنا الـ input ثابت،
+
+72
+00:06:59,540 --> 00:07:03,380
+بس كل واحدة من الـ nodes لها إيش؟ W
+
+73
+00:07:05,370 --> 00:07:09,130
+فكل واحد بتحسب الفرق ما بين الـ input وما بين الـ W
+
+74
+00:07:09,130 --> 00:07:13,950
+تبعتها، اللي هي الوزن تبعها. فـ D1 هي عبارة عن الوزن
+
+75
+00:07:13,950 --> 00:07:23,230
+ما بين أو المسافة ما بين X ناقص W1. D2
+
+76
+00:07:23,230 --> 00:07:34,270
+ساوى X ناقص W2. D3 ساوى X ناقص W3. مرة أخرى بأطرح أنا
+
+77
+00:07:34,270 --> 00:07:37,310
+الـ two vectors من بعض، يعني أنا بحسب المسافة على الـ
+
+78
+00:07:37,310 --> 00:07:40,230
+Cartesian plane ما بينهم. المسافة هذه هي حاصل
+
+79
+00:07:40,230 --> 00:07:49,230
+تجذير تبع مجموع المربعين، الـ Pythagorean distance، صح؟
+
+80
+00:07:49,230 --> 00:07:55,250
+هذا رقم، في الآخر بيطلع رقم، هو عدد كمان continuous،
+
+81
+00:07:55,250 --> 00:08:00,690
+يعني الرقم هذا هو عبارة عن الـ distance. الرقم هذا
+
+82
+00:08:01,710 --> 00:08:05,230
+ثلاثة أرقام هيطلع معايا، كل node هيطلع لها رقم واحد.
+
+83
+00:08:05,230 --> 00:08:13,610
+منهم هو الـ node اللي بتطلع الرقم الأقل، بنعتبرها
+
+84
+00:08:13,610 --> 00:08:17,370
+winner. winner، فائزة. مش كنا بنقول competitive
+
+85
+00:08:17,370 --> 00:08:21,170
+learning؟ كإنهم هما الثلاثة بيتنافسوا على هذا الـ input،
+
+86
+00:08:21,170 --> 00:08:26,690
+مين منهم أصلاً الـ weight vector تبعه أقرب إلى هذا
+
+87
+00:08:26,690 --> 00:08:32,400
+الـ input؟ أقرب، الـ distance أقل، هذا الـ winner. هذا الـ
+
+88
+00:08:32,400 --> 00:08:37,380
+winner هو اللي بيعدل أوزانه، والباقيين ما بيعدلوش
+
+89
+00:08:37,380 --> 00:08:45,160
+أوزانهم. بمعنى إيش؟ بمعنى إنه
+
+90
+00:08:45,160 --> 00:08:49,240
+if
+
+91
+00:08:49,240 --> 00:08:54,920
+الـ neuron J wins the competition، بمعنى إنه الـ
+
+92
+00:08:54,920 --> 00:08:57,960
+weight vector تبعه أقرب إلى الـ input اللي دخل، طبعاً
+
+93
+00:08:57,960 --> 00:09:00,900
+الـ input بدخل iteration ورا iteration، في هذه الـ
+
+94
+00:09:00,900 --> 00:09:06,140
+iteration، كل neuron حسب الـ distance تبعته عن هذا الـ
+
+95
+00:09:06,140 --> 00:09:10,960
+input، فالأقل distance هو اللي بيكون الـ winner. فإذا
+
+96
+00:09:10,960 --> 00:09:18,640
+هو الـ winner، بينعمل، بيحسب الـ delta. وإلا إذا الـ
+
+97
+00:09:18,640 --> 00:09:23,480
+neuron loses the competition، الـ delta صفر. بمعنى
+
+98
+00:09:23,480 --> 00:09:29,060
+إيش؟ صفر، يعني ما بيتم تعديل الأوزان. تخيل أنت الآن
+
+99
+00:09:29,060 --> 00:09:34,390
+iteration ورا iteration، بندخل inputs، input ورا
+
+100
+00:09:34,390 --> 00:09:38,670
+input، وفي كل iteration واحد من الثلاثة هيكون
+
+101
+00:09:38,670 --> 00:09:41,990
+winner، أو واحد من مجموعة الـ output يعني neurons،
+
+102
+00:09:41,990 --> 00:09:46,770
+هيكون winner، فهيتعدل وزنه تبعه في اتجاه هذا الـ
+
+103
+00:09:46,770 --> 00:09:50,530
+input اللي دخل. الـ iteration اللي بعدها هيدخل input
+
+104
+00:09:50,530 --> 00:09:54,190
+ثاني، هيروح واحد ثاني، ربما يكون هو الـ winner أو هو
+
+105
+00:09:54,190 --> 00:09:58,190
+نفسه اللي كان winner في الـ iteration اللي قبل، يكون
+
+106
+00:09:58,190 --> 00:10:02,300
+winner برضه في الـ iteration اللي بعدها. ليش؟ بصدفة إن
+
+107
+00:10:02,300 --> 00:10:05,840
+الـ two inputs اللي دخلوا ورا بعض قريبين من نفس
+
+108
+00:10:05,840 --> 00:10:10,520
+المكان، قريبين يعني من بعض، وهو قريب منهم، فهو اللي
+
+109
+00:10:10,520 --> 00:10:13,260
+كان winner في الأولى وهو اللي كان winner في
+
+110
+00:10:13,260 --> 00:10:16,920
+الثانية، وربما أيضاً في الثالثة. المهم إن في عندي
+
+111
+00:10:16,920 --> 00:10:21,640
+ثلاثة nodes وفي الـ input، فالـ nodes هذه بتعدّل
+
+112
+00:10:21,640 --> 00:10:28,340
+الأوزانها على حسب الـ input اللي دخل. تخيل معايا
+
+113
+00:10:32,610 --> 00:10:35,190
+ما عنديش slide هنا توضّح الموضوع، خليني أرسمها على
+
+114
+00:10:35,190 --> 00:10:47,330
+اللوح. خيال
+
+115
+00:10:47,330 --> 00:10:53,170
+معايا إن الـ inputs اللي هي الـ X الكبيرة من 1 إلى N،
+
+116
+00:10:53,170 --> 00:10:59,650
+كل واحد بدخل على الـ network بدي أرفله بنقطة، أفترض
+
+117
+00:10:59,650 --> 00:11:06,570
+إن كان تمثيلهم بشكل هكذا، ماذا أفعل؟ أضع نقطة مقابل
+
+118
+00:11:06,570 --> 00:11:22,450
+كل واحد من الـ input. ماذا
+
+119
+00:11:22,450 --> 00:11:27,810
+تلاحظ إن أنا بعمل؟ أنا بعمل مثل تجمعين.
+
+120
+00:11:31,300 --> 00:11:36,220
+هذه تجمع، آخر هنا.
+
+121
+00:11:36,220 --> 00:11:41,980
+أفترض إن أنا عندي مئة، أيوة، two clusters. أنا عندي
+
+122
+00:11:41,980 --> 00:11:52,080
+مئة ومئة هذول، إذا قمت معهم X1، X2، تمام؟ كل واحد
+
+123
+00:11:52,080 --> 00:11:57,200
+من هذول له إحداثيات X1، X2. هذه X1 وهذه X2.
+
+124
+00:11:59,940 --> 00:12:04,460
+وأنا جايّ بآرسل الـ plotting لإيش؟ لإحدى ثلاثة على
+
+125
+00:12:04,460 --> 00:12:08,240
+الـ plane. بعد ما خلصت الـ plotting بتطلع لي إنّه
+
+126
+00:12:08,240 --> 00:12:13,240
+النقاط أصلاً هي طبيعتها clustered
+
+127
+00:12:13,240 --> 00:12:20,500
+على two groups، في ربما فاصل أو متداخلين في منطقة
+
+128
+00:12:20,500 --> 00:12:23,760
+التداخل. مش هذا الأشكال، الأشكال إنه الآن أنت فاكر،
+
+129
+00:12:23,760 --> 00:12:28,580
+فاكر لو أنا الآن بأرسل الـ point  لديّ للـ network،
+
+130
+00:12:29,210 --> 00:12:33,250
+الـ network، نفترض إنها فيها بس two nodes على الـ output
+
+131
+00:12:33,250 --> 00:12:40,150
+layer، two nodes only. في
+
+132
+00:12:40,150 --> 00:12:45,410
+كل مرة أرمي input واحد من هذول يكون هو الـ winner،
+
+133
+00:12:45,410 --> 00:12:52,210
+نفرض أول input أنا رميتة كان هذا، نفترض إن الـ two
+
+134
+00:12:52,210 --> 00:12:58,310
+nodes هذول، الـ weight vector تبعهم كان واحد منهم
+
+135
+00:12:58,780 --> 00:13:08,180
+هذا، بالواحد، والثاني هذا، بالاثنين. واضح؟ إن الـ gram
+
+136
+00:13:08,180 --> 00:13:14,180
+ده، هدول، هدول الـ initial weight vectors. طيب الآن،
+
+137
+00:13:14,180 --> 00:13:17,880
+بالنظر، النظر، الحكاية صعبة شوية هنا. ده خلينا نقول
+
+138
+00:13:17,880 --> 00:13:25,360
+إنّه هذا هو أول input أنا أعطيته للـ network. الآن،
+
+139
+00:13:25,360 --> 00:13:31,480
+بالنظر برضه أيضاً صعب، خلينا نجرب هذا شوية. وهذا هو
+
+140
+00:13:31,480 --> 00:13:38,760
+اللي هيفوز هيفوز، ماشي. الآن لما بيفوز، إيش يعني
+
+141
+00:13:38,760 --> 00:13:43,500
+بيفوز؟ بنعدّل أوزانه، لأ، بنعدّل أوزانه. إذا أنا
+
+142
+00:13:43,500 --> 00:13:49,700
+موجود، كفاية عند معادلة تعديل الوزن بس، هي أنت
+
+143
+00:13:49,700 --> 00:13:50,580
+ترجعها
+
+144
+00:13:55,630 --> 00:13:59,610
+هيئته عبارة عن إيش؟ عبارة عن α، الـ learning rate،
+
+145
+00:13:59,610 --> 00:14:04,970
+اللي بنعرفه، مضروب في الفرق ما بين مين؟ ما بين الـ
+
+146
+00:14:04,970 --> 00:14:10,650
+إيش؟ الـ X و الـ W. طبعاً أنا عندي هنا بحسب Wij، بمعنى
+
+147
+00:14:10,650 --> 00:14:20,010
+إنّ هذه كانت الـ winner، فهي Wij، وW يعني هذه واحد لـ
+
+148
+00:14:20,010 --> 00:14:25,520
+J وهذه اثنين لـ J. فبنحسب لهذه للحد وهذه للأخرى بغضّ
+
+149
+00:14:25,520 --> 00:14:30,180
+النظر على مقدار
+
+150
+00:14:30,180 --> 00:14:37,240
+الزيادة. الفرق بين الـ X و الـ W مضروب في
+
+151
+00:14:37,240 --> 00:14:45,280
+learning rate. نفترض إن الفرق كان 3 مضروب في 0.1،
+
+152
+00:14:45,280 --> 00:14:49,260
+يعني 0.3.
+
+153
+00:14:53,040 --> 00:15:00,920
+بالموجب أو بالسالب، المهم إن المسافة هتقترب. الـ W
+
+154
+00:15:00,920 --> 00:15:07,880
+الوضع الجديد تبعه هيقترب من الـ input بمقدار 0.3.
+
+155
+00:15:07,880 --> 00:15:17,620
+فهذا الـ W1 هتصير هنا، يعني تنشد إلى الـ input اللي
+
+156
+00:15:17,620 --> 00:15:22,180
+دخل. افترض بعد هيك إن الـ input الثاني اللي دخل كان
+
+157
+00:15:22,180 --> 00:15:29,120
+هنا. كان هذا، هذا أقرب لمين؟ هذا وهذا وهذا وهذا
+
+158
+00:15:29,120 --> 00:15:33,960
+وهذا وهذا وهذا.
+
+159
+00:15:33,960 --> 00:15:40,060
+وهذا وهذا وهذا وهذا وهذا وهذا وهذا وهذا.
+
+160
+00:15:40,060 --> 00:15:41,880
+وهذا وهذا وهذا وهذا وهذا وهذا وهذا.
+
+161
+00:15:41,880 --> 00:15:41,920
+وهذا وهذا وهذا وهذا وهذا وهذا وهذا.
+
+162
+00:15:41,920 --> 00:15:42,060
+وهذا وهذا وهذا وهذا وهذا وهذا وهذا.
+
+163
+00:15:42,060 --> 00:15:42,140
+وهذا وهذا وهذا وهذا وهذا وهذا وهذا.
+
+164
+00:15:42,140 --> 00:15:42,160
+وهذا وهذا وهذا وهذا وهذا وهذا وهذا.
+
+165
+00:15:42,160 --> 00:15:42,520
+وهذا وهذا وهذا وهذا وهذا وهذا وهذا.
+
+166
+00:15:42,520 --> 00:15:42,740
+وهذا وهذا وهذا وهذا وهذا وهذا وهذا.
+
+167
+00:15:42,740 --> 00:15:42,780
+وهذا وهذا وهذا وهذا وهذا وهذا وهذا.
+
+168
+00:15:42,780 --> 00:15:48,800
+وهذا وهذا وهذا وهذا.
+
+169
+00:15:54,180 --> 00:15:59,660
+تتغير في اتجاهها، في اتجاه مراكزها. هذه المجموعة هي
+
+170
+00:15:59,660 --> 00:16:04,000
+مركزها، وهذه المجموعة هي مركزها. هنلاقي إنه في الآخر
+
+171
+00:16:04,000 --> 00:16:11,940
+الـ network بعد عملية الـ training، استقرت الأوزان في
+
+172
+00:16:11,940 --> 00:16:17,040
+منتصف كل cluster. وزن هذا هيجي هنا، ووزن هذا هيجي
+
+173
+00:16:17,040 --> 00:16:19,500
+هنا. ممكن العكس، ممكن هذا اللي هيجي هنا وهذا اللي
+
+174
+00:16:19,500 --> 00:16:24,090
+هيجي هنا. ما بنعرفش، بس القصد إنه أنا أعطيتها الـ input،
+
+175
+00:16:24,090 --> 00:16:28,270
+وعلى فكرة أنا حاطط two nodes في الـ output layer،
+
+176
+00:16:28,270 --> 00:16:34,290
+على
+
+223
+00:20:05,230 --> 00:20:10,130
+الأوزان بطريقة وهذه الحسبة مختلفة شوية صغيرة عن
+
+224
+00:20:10,130 --> 00:20:14,250
+حسبة الـ A إنما هي كل آلية بتعملها اللي هو أول شيء
+
+225
+00:20:14,250 --> 00:20:20,630
+بيعمل summation وبعدين بيعمل activation يطلع ال
+
+226
+00:20:20,630 --> 00:20:22,910
+output، والـ output يطلع على الـ layer اللي بعده
+
+227
+00:20:22,910 --> 00:20:29,990
+إنما إن هو بيشتغل بشكل مستقل، بيعمل حسبة وبناء على ال
+
+228
+00:20:29,990 --> 00:20:33,110
+output بيقرر يطلع. إنت إيش كنت بتقول يا توفيق إنه يطلع
+
+229
+00:20:33,750 --> 00:20:37,930
+layer هنا و layer هنا، لو طلع output معين، الـ output
+
+230
+00:20:37,930 --> 00:20:41,210
+هذا مشترك مع output تاني طلع قبله في نفس ال
+
+231
+00:20:41,210 --> 00:20:48,490
+network، أنا هعرف إن في عندي pattern اتكرر، بس هذا
+
+232
+00:20:48,490 --> 00:20:51,930
+المعلومة موجودة على نطاق الـ network كلها، الـ
+
+233
+00:20:51,930 --> 00:20:54,850
+pattern الـ network كلها بتشوفها، ما بشوفهاش neuron
+
+234
+00:20:54,850 --> 00:20:57,870
+لحاله، neuron متعامل بسمع... أنا جزء عن مستوى ال
+
+235
+00:20:57,870 --> 00:21:01,250
+layer، على مستوى الـ layer، آه إنت ممكن على مستوى الـ layer
+
+236
+00:21:01,250 --> 00:21:04,290
+تفحص الـ pattern هذه كلها وتشوف إذا كان الـ
+
+237
+00:21:04,290 --> 00:21:06,150
+pattern هذه شافها قبل كده، إيش بعد كده اللي بدك
+
+238
+00:21:06,150 --> 00:21:09,690
+تسويه بعد كده، أنا كل ما اتكررت الـ patterns
+
+239
+00:21:09,690 --> 00:21:14,690
+أكتر، كل ما أنا جمعت وعملت لهم classification تحت
+
+240
+00:21:14,690 --> 00:21:20,150
+labels معينة، آه هو إحنا الآن هذا هو إيش اللي بيصير
+
+241
+00:21:20,150 --> 00:21:23,190
+إن هذا بيعمل شيء قريب من الكلام اللي بيقوله إنت
+
+242
+00:21:23,190 --> 00:21:27,470
+لأن يوم إنت بتعطي input
+
+243
+00:21:29,760 --> 00:21:33,740
+الـ input اللي أعطيته، يعني إذا بينتمي إلى الـ cluster
+
+244
+00:21:33,740 --> 00:21:37,440
+الأولى، هذا الـ neuron هو اللي هيكون winner، هو اللي
+
+245
+00:21:37,440 --> 00:21:41,260
+هيعطيك minimum distance value، فأنت هتعرف خلاص إن هذا
+
+246
+00:21:41,260 --> 00:21:47,120
+الـ input اللي دخل بينتمي إلى الـ cluster هذه، مش
+
+247
+00:21:47,120 --> 00:21:49,540
+عارف كيف؟ يعني إنت هتميز الـ pattern مش إنّه بيقول
+
+248
+00:21:49,540 --> 00:21:52,370
+pattern، ما هو الـ input هو عبارة عن pattern، الـ network
+
+249
+00:21:52,370 --> 00:21:56,470
+الآن بتميز هذه الـ patterns مش إنها شافتها قبل كده
+
+250
+00:21:56,470 --> 00:22:02,890
+لإنها قريبة من المركز تبع مجموعة الـ patterns
+
+251
+00:22:02,890 --> 00:22:08,270
+هذول، هذول ما هم patterns، طيب نرجع ناخد المثال
+
+252
+00:22:08,270 --> 00:22:16,610
+هذا على السريع علشان نفهم فكرة عمل الـ competitive
+
+253
+00:22:16,610 --> 00:22:19,290
+learning networks
+
+254
+00:22:21,560 --> 00:22:27,780
+بشكل عام، فإحنا نفترض إن في، إحنا المثال اللي بدأنا
+
+255
+00:22:27,780 --> 00:22:29,420
+فيه اللي هو ثلاثة neurons
+
+256
+00:22:57,320 --> 00:23:07,760
+هذه هي الـ initial weights، الوزن W1 0.27 0.81، W2 0
+
+257
+00:23:07,760 --> 00:23:18,400
+.42 0.70، W3 0.43 0.21، الـ input اللي دخل الآن هذا
+
+258
+00:23:18,400 --> 00:23:25,960
+لسه
+
+259
+00:23:25,960 --> 00:23:35,930
+عبارة عن 0.52 و 0.12، ببساطة شديدة، وكل ما
+
+260
+00:23:35,930 --> 00:23:40,310
+هنعمله الآن هو نحسب مين الـ winner، نحدد مين الـ winner، و
+
+261
+00:23:40,310 --> 00:23:53,750
+بعدين نعدل أوزانه، وبس. فالـ distance دي واحد اشتغل
+
+262
+00:23:55,580 --> 00:24:00,540
+X1-W1  X1-W1  X1-W1  X1-W1  X1-W1  X1-W1  X1-W1
+
+263
+00:24:00,540 --> 00:24:03,780
+-W1  X1-W1  X1-W1  X1-W1  X1-W1  X1-W1  X1-W1
+
+264
+00:24:03,780 --> 00:24:06,260
+-W1  X1-W1  X1-W1  X1-W1  X1-W1  X1-W1  X1-W1
+
+265
+00:24:06,260 --> 00:24:06,380
+-W1  X1-W1  X1-W1  X1-W1  X1-W1  X1-W1  X1-W1
+
+266
+00:24:06,380 --> 00:24:06,400
+-W1  X1-W1  X1-W1  X1-W1  X1-W1  X1-W1  X1-W1
+
+267
+00:24:06,400 --> 00:24:12,380
+-W1  X1-W1  X1-W1  X1-W1  X1-W1  X1-W1  X1-W1
+
+268
+00:24:12,380 --> 00:24:16,940
+-W1
+
+269
+00:24:16,940 --> 00:24:23,700
+1 X1
+
+270
+00:24:23,840 --> 00:24:30,160
+81 تحت تربيع، تحت الجذر يطلع 0.73، نفس العملية لـ D2
+
+271
+00:24:30,160 --> 00:24:36,200
+نفس العملية لـ D3،  الوزن اللي قلناه هنا، وفر
+
+272
+00:24:36,200 --> 00:24:44,080
+للأقل اللي هو D3، صح؟ أو node 3، node 3 الآن بدأ تعديل
+
+273
+00:24:44,080 --> 00:24:51,800
+أوزانه، نحسب الوزن هذا اللي هو 0.13، صح؟ 0.13 بيساوي الـ 0
+
+274
+00:24:51,800 --> 00:24:56,880
+.1 السابق زائد الـ Delta، هو لأنه بيحسب الـ Delta
+
+275
+00:24:56,880 --> 00:25:06,520
+Delta 0.13 اللي هي عبارة عن X1 ناقص W، الوزن تبعها 0
+
+276
+00:25:06,520 --> 00:25:13,600
+.1، صح؟ هذا الكلام مضروب في إيش؟ في Alpha، Alpha أخدناها
+
+277
+00:25:13,600 --> 00:25:23,180
+على أنها 0.1 يعني 10%، ويطلع 0.01، هذا الـ Delta يضاف
+
+278
+00:25:23,180 --> 00:25:29,600
+على السابق، السابق اللي هو 0
+
+279
+00:25:29,600 --> 00:25:37,880
+.43، يطلع 0.44، الوزن
+
+280
+00:25:37,880 --> 00:25:46,000
+التاني اللي هو W2، 3 X
+
+281
+00:25:46,000 --> 00:25:55,380
+2، اللي هو الـ 0.12 ناقص الـ 0.21، مظبوط، برضه مضروب
+
+282
+00:25:55,380 --> 00:26:02,760
+في الـ alpha بسالب الـ 0.21، تمام، مع السابق لأن أخذنا
+
+283
+00:26:02,760 --> 00:26:06,320
+الأوزان
+
+284
+00:26:06,320 --> 00:26:10,300
+تبع ثلاثة، بس تعديل الأوزان السابق تبع ثلاثة اللي
+
+285
+00:26:10,300 --> 00:26:17,180
+هم 0.43 والـ 0.21، جمعنا عليهم الـ 0.01 والسالب 0
+
+286
+00:26:17,180 --> 00:26:22,080
+.01، يطلع 0.44 و 0.20، هذا الآن وزن جديد تبع هذا، وهذول
+
+287
+00:26:22,080 --> 00:26:29,640
+أوزانهم زي ما هم، مصفوفة، مصفوفة،
+
+288
+00:26:29,640 --> 00:26:32,960
+هذا دائماً، إحنا شفناها قبل كده، محكومة بالـ learning
+
+289
+00:26:32,960 --> 00:26:37,980
+rate، فيه error، تمام، okay، بس إحنا الآن هنا ما فيش
+
+290
+00:26:37,980 --> 00:26:43,430
+أي error لأن ما فيش desired، آه مش supervised، فإيش
+
+291
+00:26:43,430 --> 00:26:46,390
+اللي بيحكمك لما يخلص الـ input، لما يخلص الـ input
+
+292
+00:26:46,390 --> 00:26:50,410
+إنت عندك data set، إنت عندك data set، جدول اللي فيه
+
+293
+00:26:50,410 --> 00:26:55,030
+العناصر، لما نخلصه، بدك تكرر epoch، آخر الـ epoch اللي
+
+294
+00:26:55,030 --> 00:26:59,190
+هو إيش قلنا؟ short، يعني إنت ممكن تدخلهم كلهم و
+
+295
+00:26:59,190 --> 00:27:04,030
+بعدين تقول لأ، بتعلمها، بيخليها يعني أؤكد عليها كمان
+
+296
+00:27:04,030 --> 00:27:09,210
+زيادة. سؤال، الـ vectors X1 وX2 لازم يكون لهم نفس الـ
+
+297
+00:27:09,210 --> 00:27:14,200
+size، يعني عدد العناصر، ما هو إنت الآن ليش اللي بيحكم
+
+298
+00:27:14,200 --> 00:27:17,140
+الـ vectors اللي هو الـ input، إذا أنا عندي، إذا أنا
+
+299
+00:27:17,140 --> 00:27:19,940
+عندي ثلاثة inputs أو الـ input اللي عندي ثلاثة
+
+300
+00:27:19,940 --> 00:27:24,430
+items، تمام، ده الـ size كل vector من الـ vectors
+
+301
+00:27:24,430 --> 00:27:27,790
+هذول، يعني أي عناصر... أي عناصر هذه... هذه... هذه
+
+302
+00:27:27,790 --> 00:27:30,530
+الـ input... الـ input vector، آه حسب الـ data اللي
+
+303
+00:27:30,530 --> 00:27:34,750
+عندك إنت، أنا مثلاً بدي أميز ما بين قطة و كلب مثلاً
+
+304
+00:27:34,750 --> 00:27:38,690
+إيش في عندي صفات أو خصائص؟ في عندي الطول، الوزن، ال
+
+305
+00:27:38,690 --> 00:27:43,730
+... كده، كده، كده، هذه الخصائص، تمام، فحسب إيش عندي
+
+306
+00:27:43,730 --> 00:27:48,930
+خصائص، بدخلها، على كل خاصية... كل خاصية عبارة عن
+
+307
+00:27:48,930 --> 00:27:53,250
+node في الـ input layer، زي ما ذكرنا، كذلك حالة
+
+308
+00:27:53,250 --> 00:27:59,450
+مثالية، character recognition، حسب إيش الـ input، الـ
+
+309
+00:27:59,450 --> 00:28:02,870
+data
+
+310
+00:28:02,870 --> 00:28:05,890
+item اللي عندك، كم خاصية فيه؟ هذول نسميهم إحنا
+
+311
+00:28:05,890 --> 00:28:11,110
+features، اسمها ميزات، خصائص، وهي ممكن تكون binary، يعني إن
+
+312
+00:28:11,110 --> 00:28:13,930
+الخاصية دي موجودة أو مش موجودة، واحدة، ما بيبقى
+
+313
+00:28:13,930 --> 00:28:17,110
+جايلهاش numeric value بيدل على قد إيش مدى توفر
+
+314
+00:28:17,110 --> 00:28:21,950
+الخاصية، يعني مثلاً إن هو طويل، طويل بالنسبة لـ قد إيش؟ إذا
+
+315
+00:28:21,950 --> 00:28:25,930
+كنتوا تتذكروا في الفصل، إذا هو مثلاً أي خاصية ممكن
+
+316
+00:28:25,930 --> 00:28:31,710
+نعبر عنها بـ range، بـ scale، تمام، فهنا الآن أعتقد إنه
+
+317
+00:28:31,710 --> 00:28:38,130
+وضحت الفكرة، إنه الـ training بيشتغل على إنه بس الـ
+
+318
+00:28:38,130 --> 00:28:41,750
+winner، الـ winner اللي هو الأقل distance هو اللي
+
+319
+00:28:41,750 --> 00:28:44,610
+بتعدل وزنه، والتانين بيضلوا زي ما هم، في الـ
+
+320
+00:28:44,610 --> 00:28:49,200
+iteration اللي بعدها، وهكذا. Okay، فعندنا إحنا الـ
+
+321
+00:28:49,200 --> 00:28:51,600
+competitive learning algorithm بتنطوي على
+
+322
+00:28:51,600 --> 00:28:54,180
+initialization، الـ initialization اللي هو بناء الـ
+
+323
+00:28:54,180 --> 00:29:00,660
+network ووضع الأوزان الإبتدائية بشكل عشوائي، تمام
+
+324
+00:29:00,660 --> 00:29:06,500
+الـ activation، الـ activation اللي عندنا هنا اللي هو
+
+325
+00:29:06,500 --> 00:29:09,740
+اللي شفناه في الـ neural networks اللي شفناها قبل كده
+
+326
+00:29:09,740 --> 00:29:13,330
+كان الـ activation بيشتمل على ضرب الـ input في
+
+327
+00:29:13,330 --> 00:29:22,110
+الأوزان، ثم بعد ذلك الـ threshold، ثم بعد ذلك نحسب
+
+328
+00:29:22,110 --> 00:29:25,830
+error، ثم بناء على الـ error بتعدل الأوزان، هذا الكلام
+
+329
+00:29:25,830 --> 00:29:29,710
+مش موجود هنا، الـ activation هنا ما هو؟ سواء إنه
+
+330
+00:29:29,710 --> 00:29:34,190
+similarity matching، بنشوف قد إيش الـ input اللي دخل
+
+331
+00:29:34,190 --> 00:29:37,860
+similar، قد إيش بيشبه، يعني الـ distance هذه إيش معناها
+
+332
+00:29:37,860 --> 00:29:40,720
+هذه؟ لما تكون الـ distance صغيرة بين الـ two
+
+333
+00:29:40,720 --> 00:29:44,400
+vectors، معناته قريبين على بعض، معناته similar، okay
+
+334
+00:29:44,400 --> 00:29:48,120
+هذا الحساب في ال... في ال... في الـ feature، وفي
+
+335
+00:29:48,120 --> 00:29:51,220
+الـ feature vectors، شائع لما نقول إن two vectors
+
+336
+00:29:51,220 --> 00:29:54,580
+are similar إذا كان الـ distance بينهم قريبة من الـ
+
+337
+00:29:54,580 --> 00:29:59,360
+zero، صح؟ صح؟ هذول are two vectors، فالـ similarity ما
+
+338
+00:29:59,360 --> 00:30:04,890
+جاءت هي إن إحنا بنحسب الفرق ما بينهم، بناخد... بنشوف من
+
+339
+00:30:04,890 --> 00:30:09,950
+الـ minimum في كل ال... في كل هذه الأوزان، وبنروح
+
+340
+00:30:09,950 --> 00:30:13,950
+بنعمل عملية اللي هو التعديل، عملية التعديل بناء على
+
+341
+00:30:13,950 --> 00:30:16,310
+الـ step رقم two، اللي هي الـ learning اللي هي
+
+342
+00:30:16,310 --> 00:30:19,510
+عملية التعديل، إن الوزن الجديد بيساوي الوزن السابق
+
+343
+00:30:19,510 --> 00:30:25,850
+زائد الـ delta، والـ delta بتعتمد على إذا كان، إذا كان
+
+344
+00:30:25,850 --> 00:30:31,770
+ال... هو، الج هي الـ winner، تمام، فتاخد... بتعمل تعديل
+
+345
+00:30:31,770 --> 00:30:43,270
+إذا مش winner، delta zero، وبعدين هي بتكرر الموضوع هذا
+
+346
+00:30:43,270 --> 00:30:57,430
+المثال الثاني، في عندك network نفكر
+
+347
+00:30:57,430 --> 00:31:00,790
+فيها على شكل زي ما راسمه هنا في البداية
+
+348
+00:31:04,520 --> 00:31:07,560
+تخيل إن الـ network، الـ layer هذه، الـ output layer
+
+349
+00:31:07,560 --> 00:31:13,000
+two-dimensional، كيف هي two-dimensional؟ هي زي هذه
+
+350
+00:31:13,000 --> 00:31:26,300
+المصفوفة دي، أنا عمود، عندي مصفوفة من
+
+351
+00:31:26,300 --> 00:31:30,200
+الـ nodes، من الـ nodes، ما هو الإختلاف؟ هذه الـ layer،
+
+352
+00:31:30,200 --> 00:31:35,790
+تخيلها الآن علي إنها عبارة عن الـ plane، الـ plane
+
+353
+00:31:35,790 --> 00:31:40,850
+هذا موجود عليه الجماعة هذول، وعندي أنا two أو
+
+354
+00:31:40,850 --> 00:31:45,990
+three nodes، بدهم ياخدوا، الـ two nodes اللي في الـ input
+
+355
+00:31:45,990 --> 00:31:50,210
+layer، بدهم ياخدوا ويعطوا لمين؟ لـ الـ nodes اللي فيها
+
+356
+00:31:50,210 --> 00:31:53,750
+أوزان، أصبحت كل هذه الـ input layer، صح؟ أصبح كل
+
+357
+00:31:53,750 --> 00:31:58,070
+element هنا، كل node هنا، بدي أعطي لكل واحد من هذول
+
+358
+00:31:58,070 --> 00:32:03,710
+صح؟ أصبح كل واحد من هذول بدي آخذها، ماخذة من الاثنين
+
+359
+00:32:04,150 --> 00:32:08,230
+هذه، ماخذة two inputs وهذه كلها، وكل واحدة منهم
+
+360
+00:32:08,230 --> 00:32:16,830
+ماخذة two، إختلف شيء؟ لأ، وضحت المسألة هي هي، وده
+
+361
+00:32:16,830 --> 00:32:25,690
+نحسب الـ winner في كل المصفوفة هذه، في إختلاف شغل
+
+362
+00:32:25,690 --> 00:32:31,990
+آخر صغير، وهي إن إحنا مش شايفين هنا ولا هنا، بس
+
+363
+00:32:31,990 --> 00:32:39,750
+عادةً في connections ما بينهم
+
+364
+00:32:39,750 --> 00:32:45,450
+إيش يعني؟ زي ما إن الـ node بتاخد الـ input اللي هنا
+
+365
+00:32:45,450 --> 00:32:49,130
+بتاخد الـ input من هنا، الـ nodes اللي هنا عارفين
+
+366
+00:32:49,130 --> 00:32:55,590
+جيرانهم، كل node آه متصلة، هذا الـ node متصلة بالـ
+
+367
+00:32:55,590 --> 00:33:01,670
+nodes اللي حولها، من أجل إيش؟ من أجل إن كل node
+
+368
+00:33:01,670 --> 00:33:08,210
+تعرف بس مين جيرانها، يعني هي دلوقت الـ node وهي الجيران
+
+369
+00:33:08,210 --> 00:33:14,390
+تبعها، الثمانية دول، إيش الهدف من ذلك؟ الهدف من ذلك
+
+370
+00:33:14,390 --> 00:33:19,690
+إن عملية تعديل الأوزان، قلنا إحنا بس الـ winner هي
+
+371
+00:33:19,690 --> 00:33:23,610
+اللي بتعدل أوزانها، مظبوط، في هذه الـ configuration
+
+372
+00:33:23,610 --> 00:33:27,890
+في هذه الـ networks، بنخلي الـ winner وجيرانه برضه
+
+373
+00:33:27,890 --> 00:33:31,950
+يعدلوا أوزانهم، جيران
+
+374
+00:33:31,950 --> 00:33:38,130
+لغاية أي مدى؟ هذه قضية يمكن تحديدها حسب الـ
+
+375
+00:33:38,130 --> 00:33:42,470
+application، لغاية أي مدى؟ يعني على بعد سابع جار ولا
+
+376
+00:33:42,470 --> 00:33:46,990
+سادس ولا ثالث جار ولا بس أول جار اللي هم الثمانية
+
+377
+00:33:46,990 --> 00:33:54,410
+المحيطين، هذا أول شغلة، اللي هو تعديل الأوزان، و
+
+378
+00:33:54,410 --> 00:34:01,430
+بعدين هل كلهم يعدلوا أوزانهم بنفس الكيفية؟ ولا اللي
+
+379
+00:34:01,430 --> 00:34:08,800
+أقرب يعدل أكثر، بحجم أكثر، والأبعد أقل، عندك معادلة
+
+380
+00:34:08,800 --> 00:34:17,020
+هذه أو الـ function هذه، لحظة
+
+381
+00:34:17,020 --> 00:34:19,880
+الأسهم هذه ما حكيناهاش وإحنا بنشرح في الأول
+
+382
+00:34:19,880 --> 00:34:24,660
+الأسهم مقصود بيها الـ connections ما بين الـ nodes
+
+383
+00:34:24,660 --> 00:34:30,760
+تبع الـ output layer، سواء كان عمود أو شبكة matrix
+
+384
+00:34:30,760 --> 00:34:35,820
+هنا برضه بتتغير الأوزان، في المثال الأول ما حكيناهاش، بس
+
+385
+00:34:35,820 --> 00:34:39,840
+الآن لما نكون في عندي network هتسيّر عليها تعديل
+
+386
+00:34:39,840 --> 00:34:44,200
+الأوزان مبنية على أساس الـ distance، إن الـ winner و
+
+387
+00:34:44,200 --> 00:34:47,980
+جيرانه، حتى في المثال هذا، في المثال هذا، حسب المثال
+
+388
+00:34:47,980 --> 00:34:52,500
+إذا جالك المثال إن هذول ال
+
+445
+00:39:51,580 --> 00:39:54,460
+أوزانه، وممكن الـ winner والـ neighborhood تبعته
+
+446
+00:39:54,460 --> 00:39:58,340
+يعدل أوزانهم، والـ neighborhood تحديدها بناءً على
+
+447
+00:39:58,340 --> 00:40:02,540
+neighborhood function اللي ممكن تبقى square أو
+
+448
+00:40:02,540 --> 00:40:05,500
+ممكن تبقى Mexican hat اللي هي على شكل، طبيعي كنت
+
+449
+00:40:05,500 --> 00:40:09,280
+لما كان يعدل وزن لحاله، كنا نعطيه دلتا معينة، فقلنا
+
+450
+00:40:09,280 --> 00:40:12,480
+لما بيعدل وزن وجيرانه، إيش هتصير الدلتا؟ أنا
+
+451
+00:40:12,480 --> 00:40:16,200
+بقول لك الـ node الواحدة، الـ winner نفسه بيعدل بـ
+
+452
+00:40:16,200 --> 00:40:20,400
+strength  full، تمام، الجيران بيعدلوا أوزانهم بس
+
+453
+00:40:20,400 --> 00:40:25,080
+بنضرب الوزن بالـ delta اللي عندها حسب في الـ
+
+454
+00:40:25,080 --> 00:40:29,840
+strength، الـ delta طبعاً هو بيحسبها، بس بيضربها في الـ
+
+455
+00:40:29,840 --> 00:40:37,960
+strength، فبتنخفط حسب هو وين موجود، الـ neighbor، طيب
+
+456
+00:40:37,960 --> 00:40:42,820
+ماشي، الحالة، بعملية منكون أن هنا الشق اللي اللي
+
+457
+00:40:42,820 --> 00:40:44,560
+علاقة بـ competitive learning، قلنا أن
+
+458
+00:40:44,560 --> 00:40:49,100
+competitive learning هو أحد أمثلة الـ .. الـ
+
+459
+00:40:49,100 --> 00:40:52,620
+unsupervised learning في الـ neural networks، محاضرة
+
+460
+00:40:52,620 --> 00:40:56,340
+جاية إن شاء الله، بنحكي في الـ Hebbian networks
+
diff --git a/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/q2TqaTO_Cso_postprocess.srt b/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/q2TqaTO_Cso_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..735008c16b77114493a23edd014892825c190ff0
--- /dev/null
+++ b/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/q2TqaTO_Cso_postprocess.srt
@@ -0,0 +1,2276 @@
+1
+00:00:21,060 --> 00:00:24,380
+بسم الله الرحمن الرحيم المحاضرة يا شباب اليوم ان
+
+2
+00:00:24,380 --> 00:00:32,600
+شاء الله بنبدأ موضوع جديد هو ممكن نعتبره يعني
+
+3
+00:00:32,600 --> 00:00:36,620
+استكمال ال express systems و ممكن ناخده على انه
+
+4
+00:00:36,620 --> 00:00:39,380
+موضوع منفصل كيف يعني؟ يعني موضوع ال artificial
+
+5
+00:00:39,380 --> 00:00:42,640
+neural networks اللي هو العمال الكبير ممكن يكون
+
+6
+00:00:42,640 --> 00:00:44,940
+واحدة من التقنيات اللي متقبقة في ال express
+
+7
+00:00:44,940 --> 00:00:49,440
+systemsولكن يوجد تطبيقات أخرى خارج إطار الـ
+
+8
+00:00:49,440 --> 00:00:53,900
+Express Systems نفهم التقنية هذه وجدام في شباتر
+
+9
+00:00:53,900 --> 00:00:57,700
+لاحقة نشوف كيف هذه التقنية تتوظف في Express
+
+10
+00:00:57,700 --> 00:01:01,640
+Systems المهم الآن أننا نفهمها في حد ذاتها الـ
+
+11
+00:01:01,640 --> 00:01:05,240
+Artificial neural networks في منها نوعية نوصل فيها
+
+12
+00:01:05,240 --> 00:01:09,400
+في ال supervised و ال unsupervised الآن نفهم لماذا
+
+13
+00:01:10,760 --> 00:01:14,680
+أو ال lecture هال lecture أقم سبعة بتتناول بس ال
+
+14
+00:01:14,680 --> 00:01:18,740
+supervised learning و ال lecture اللي بعدها تمانية
+
+15
+00:01:18,740 --> 00:01:22,780
+بتتناول ال unsupervised learning الكلمة الأساسية
+
+16
+00:01:22,780 --> 00:01:25,420
+هنا أنه learning هي عبارة عن واحدة من التقريات
+
+17
+00:01:25,420 --> 00:01:29,680
+اللي بتساعد في أنه نبني system، ال system ممكن
+
+18
+00:01:29,680 --> 00:01:33,540
+يتعلم، يتعلم من أيش؟ من البيانات السابقة ال
+
+19
+00:01:33,540 --> 00:01:36,980
+historical data أو ال training data بنسميها حين
+
+20
+00:01:37,350 --> 00:01:40,250
+عموما الآن شكل ال lecture هذه ال lecture السابعة
+
+21
+00:01:40,250 --> 00:01:44,950
+زي ما قلناها بتتعلق بس ب supervised learning أو
+
+22
+00:01:44,950 --> 00:01:48,510
+supervised artificial neural network المواضيع هذه
+
+23
+00:01:48,510 --> 00:01:53,130
+انا هدخل على طول على ال Perceptron المقدمة النظرية
+
+24
+00:01:53,130 --> 00:01:55,830
+هذه ممكن ان انت تستوعبها على حالك جرّا ان انت
+
+25
+00:01:55,830 --> 00:01:59,210
+تقرأها من ال slides يعني ال slides بتكفي انك
+
+26
+00:01:59,210 --> 00:02:06,690
+تستوعبها هو في الجزيجين هذوله بيمحدللموضوع من حيث
+
+27
+00:02:06,690 --> 00:02:12,170
+انه صلته بالخلايا العصبية في الدماغ وانه هي الأساس
+
+28
+00:02:12,170 --> 00:02:16,830
+لفكرة ال artificial neural networks يبقى بالأساس
+
+29
+00:02:16,830 --> 00:02:21,870
+كلمة neural networks جاي من نورا ومن نورا للخلايا
+
+30
+00:02:21,870 --> 00:02:25,950
+العصبية شبكات من الخلايا العصبية Artificial بمعنى
+
+31
+00:02:25,950 --> 00:02:30,390
+أصطناعي يعني احنا اللي عاملينها تقليد لقاليد العمل
+
+32
+00:02:30,390 --> 00:02:33,970
+تبع ال neural network ال biological
+
+33
+00:02:36,150 --> 00:02:38,910
+هذه الأسلحة ادعت انها او هؤلاء المفروضين اللي احنا
+
+34
+00:02:38,910 --> 00:02:42,190
+هنعديهم ونبدأ على طول في ال Perceptron ال
+
+35
+00:02:42,190 --> 00:02:47,250
+Perceptron اللي هو النوا اللي منها بتبنى الشبكات
+
+36
+00:02:47,250 --> 00:02:51,870
+الشبكات ال artificial neural networks عادة ما
+
+37
+00:02:51,870 --> 00:02:57,390
+بتستخدم في مسائل زي التصنيف قدام هذا الكلام هيظهر
+
+38
+00:02:57,390 --> 00:03:02,450
+مع ان بعد ما نخلص و نفهم قليت عملها فانا الآن بده
+
+39
+00:03:02,450 --> 00:03:09,650
+انتقلالحكي عن الـ Perceptron نبدأ من ال slide هذه
+
+40
+00:03:09,650 --> 00:03:17,550
+ال slide هذه توضح بنية ال Perceptron Perceptron هو
+
+41
+00:03:17,550 --> 00:03:20,990
+الخلية
+
+42
+00:03:20,990 --> 00:03:26,330
+الواحدة في النتورة أو لبنة البناء الأساسية لـ
+
+43
+00:03:26,330 --> 00:03:32,010
+Artificial neural network التكون
+
+44
+00:03:32,010 --> 00:03:38,300
+من بالأساسهذه اسمها linear combiner وهو ال hard
+
+45
+00:03:38,300 --> 00:03:51,760
+limiter ال
+
+46
+00:03:51,760 --> 00:03:57,200
+perceptron بالأساس ينظر له على الأساس انه linear
+
+47
+00:03:57,200 --> 00:04:01,320
+combiner زي ال hard limiter ممكن هذه الجزئيتين
+
+48
+00:04:01,320 --> 00:04:07,410
+ناخدهم لأنهم مكون واحدالـ Perceptor من هذا بيصله
+
+49
+00:04:07,410 --> 00:04:11,070
+input و بيطلع منه multiple inputs بيصله multiple
+
+50
+00:04:11,070 --> 00:04:17,450
+inputs و بيطلع منه one single output الوظيفة
+
+51
+00:04:17,450 --> 00:04:20,930
+الأساسية أو القالية العاملة الأساسية تبع ال
+
+52
+00:04:20,930 --> 00:04:26,610
+Perceptor اللي هو ت combine ال inputs يقارن ال
+
+53
+00:04:26,610 --> 00:04:31,490
+input ب some threshold يقارنه ب some threshold و
+
+54
+00:04:31,490 --> 00:04:35,940
+يطلع ال output بناء على هذاهل ال input أو ال sum
+
+55
+00:04:35,940 --> 00:04:41,280
+هنا combined بمعنى انه بيجمع هل ال sum هذا تجاوز
+
+56
+00:04:41,280 --> 00:04:45,320
+ال threshold إذا تجاوز بيعطي output وإذا لم يتجاوز
+
+57
+00:04:45,320 --> 00:04:50,200
+بيعطي output أخر فال output تبع ال perceptron ممكن
+
+58
+00:04:50,200 --> 00:04:54,920
+نفكر فيه على انه binary output ياما ال value هذا
+
+59
+00:04:54,920 --> 00:04:58,180
+ياما ال value هذا ال values هذه ممكن تبقى 01 او
+
+60
+00:04:58,180 --> 00:05:04,810
+plus one minus one وممكن تبقىأرقام عشرية ما بين
+
+61
+00:05:04,810 --> 00:05:08,870
+الـ 0 و الـ 1 أو ما بين الـ minus one و الplus one
+
+62
+00:05:08,870 --> 00:05:12,430
+فممكن ال output تبقى ال perceptron يبقى binary أو
+
+63
+00:05:12,430 --> 00:05:17,750
+يبقى float هذا الكلام في الآخر إيش مستفيد منه،
+
+64
+00:05:17,750 --> 00:05:19,470
+لنأخد مثال على ذلك
+
+65
+00:05:35,290 --> 00:05:38,830
+قبل المثال خلّيني أظهر برضه نكمل القالية العمال
+
+66
+00:05:38,830 --> 00:05:48,050
+اللي هي ان ال perceptron يتوزن من قالية التعامل
+
+67
+00:05:48,050 --> 00:05:55,330
+بتوعته اللي احنا قولنا فيه learning نبتد
+
+68
+00:05:55,330 --> 00:05:58,050
+مثل ال perceptron بهذا الشكل okay هاي اللي اوت
+
+69
+00:05:58,050 --> 00:06:01,850
+بتتبعه وهي ال input ال input هنا اتنين ممكن يكون
+
+70
+00:06:01,850 --> 00:06:08,590
+اكتر اه اكتر من اتنينالمهم ان ال output تبع ال ال
+
+71
+00:06:08,590 --> 00:06:13,290
+output تبع ال Perceptron ممكن يكون مطابق لل
+
+72
+00:06:13,290 --> 00:06:17,210
+desired output وممكن يكون غير مطابق يعني احنا لما
+
+73
+00:06:17,210 --> 00:06:21,270
+بندرب الشبكة او ال Perceptron زي ال Perceptron
+
+74
+00:06:21,270 --> 00:06:26,490
+الواحد لما بندربه بنعطيله desired output يعني ال
+
+75
+00:06:26,490 --> 00:06:32,530
+output السليم المرغوب فهو ال Perceptron بيقارن ال
+
+76
+00:06:32,530 --> 00:06:38,800
+output اللي طلع منهاللي حسبه هو الـ
+
+77
+00:06:38,800 --> 00:06:44,620
+Y دي هو الـ calculated output و الـ Y دي هو الـ
+
+78
+00:06:44,620 --> 00:06:48,640
+desired الفرق ما بين هدول الاتنين هي ال error اللي
+
+79
+00:06:48,640 --> 00:06:55,300
+هي الخطأ الخطأ هذا اللي هو E الان إذا في خطأ يفرض
+
+80
+00:06:55,300 --> 00:07:00,480
+انه ال perceptron يتعلم من خطأ كيف يتعلم من خطأه
+
+81
+00:07:00,480 --> 00:07:05,280
+بشكل بسيط هو انهأنا برجع تاني في ال slides لورا و
+
+82
+00:07:05,280 --> 00:07:11,400
+هي ان ال inputs هذه تبع ال Perceptron ال inputs
+
+83
+00:07:11,400 --> 00:07:21,540
+هذه X1 و X2 تمام لها أوزان W1 و W2 عملية ال
+
+84
+00:07:21,540 --> 00:07:24,960
+summation اللي بيصير بداخل ال Perceptron اللي
+
+85
+00:07:24,960 --> 00:07:27,620
+بيصير بداخل ال Perceptron هي weighted sum
+
+86
+00:07:27,620 --> 00:07:31,610
+operation المعنى انه كل inputالـ input سبعته
+
+87
+00:07:31,610 --> 00:07:34,310
+مابنجمعوش زي ما هم مابنضعوه في الأول بالإيش
+
+88
+00:07:34,310 --> 00:07:42,570
+بالأوزان تبعهم weighted sum الأوزان هذه هي المحور
+
+89
+00:07:42,570 --> 00:07:46,730
+عملية التعليق بمعنى إيش أنه إذا حسب ال perceptron
+
+90
+00:07:46,730 --> 00:07:55,750
+طلب معاه error هذا
+
+91
+00:07:55,750 --> 00:07:59,650
+ال errorبدي نعكس .. بدي ترتب عليه تعديل في الأوزان
+
+92
+00:07:59,650 --> 00:08:04,490
+أوزانها دي إما بتزيد أو بتتقيل عشان المرة الجاية
+
+93
+00:08:04,490 --> 00:08:10,310
+اللي بنعطيله ال input اللي بعد هيكه يحسب من جديد و
+
+94
+00:08:10,310 --> 00:08:15,490
+يكون اقترب أكتر من الصورة اقترب اكتر من الصورة
+
+95
+00:08:15,490 --> 00:08:18,570
+يبقى الأن آلية عمل ال perseverance اللي هي أنه
+
+96
+00:08:18,570 --> 00:08:22,570
+أولا هو بيعمل combination بيعمل combining لل input
+
+97
+00:08:22,570 --> 00:08:27,140
+طبعا بس لازم يضرب كل input بالإياشبالوزن تبعه
+
+98
+00:08:27,140 --> 00:08:32,760
+بيقارن ال sum ال total بال threshold و هنا على ال
+
+99
+00:08:32,760 --> 00:08:35,860
+threshold بيقول ال output ال output هذا بيقارنه
+
+100
+00:08:35,860 --> 00:08:39,260
+بال desired output هذا هم يكون supervised learning
+
+101
+00:08:39,260 --> 00:08:42,900
+لازم يكون ال input دخل ودخلنا معاها كمان أيش هاي
+
+102
+00:08:42,900 --> 00:08:47,860
+input بدخل و بدخل معاها كمان أيش ال desired هو
+
+103
+00:08:47,860 --> 00:08:53,100
+بيقارن هذا بهذا و الفرق ما بينهم هو عبارة عن أيش
+
+104
+00:08:54,020 --> 00:08:58,020
+بالـ error ال P هذه اختصار لل iteration يعني P1
+
+105
+00:08:58,020 --> 00:09:01,940
+سواء iteration وان احنا بندرب ال Perceptron على
+
+106
+00:09:01,940 --> 00:09:06,860
+عدة iterations P1, P2, P3 لعديد مثلا مائة
+
+107
+00:09:06,860 --> 00:09:11,340
+iterations او مائتين iterations okay الآن زي ما
+
+108
+00:09:11,340 --> 00:09:15,040
+قلنا اذا في error اذا في error ما بين ال Y اللي
+
+109
+00:09:15,040 --> 00:09:19,020
+حسبها ال Perceptron من ال Y اللي المفروض تطلع هذا
+
+110
+00:09:19,020 --> 00:09:25,090
+الكلام بنعكس على الأوزان الأوزان بتتغيركيف تتغير
+
+111
+00:09:25,090 --> 00:09:29,290
+الأوزان ببساطة
+
+112
+00:09:29,290 --> 00:09:38,450
+شديدة لان نحن جايبين الأوزان السابقة إيش
+
+113
+00:09:38,450 --> 00:09:43,010
+معناته ال iteration القادمة هذا ال iteration
+
+114
+00:09:43,010 --> 00:09:47,730
+الحالية هذا ال error هذا ال error في iteration
+
+115
+00:09:47,730 --> 00:09:50,030
+الحالية مضروب في إيش؟
+
+116
+00:09:58,070 --> 00:10:05,210
+الوزن هذا الوزن
+
+117
+00:10:05,210 --> 00:10:14,210
+السابق الوزن السابق الوزن السابق الوزن السابق
+
+118
+00:10:14,210 --> 00:10:18,550
+الوزن السابق الوزن السابق الوزن السابق الوزن
+
+119
+00:10:18,550 --> 00:10:21,130
+السابق الوزن السابق الوزن السابق الوزن السابق
+
+120
+00:10:21,130 --> 00:10:21,810
+الوزن السابق الوزن السابق الوزن السابق الوزن
+
+121
+00:10:21,810 --> 00:10:22,490
+السابق الوزن السابق الوزن السابق الوزن السابق
+
+122
+00:10:22,490 --> 00:10:22,610
+السابق الوزن السابق الوزن السابق الوزن السابق
+
+123
+00:10:22,610 --> 00:10:23,330
+الوزن السابق الوزن السابق الوزن السابق الوزن
+
+124
+00:10:23,330 --> 00:10:27,520
+السابق الوزن السابق الوزن السابق الوبنفهم ايش يعني
+
+125
+00:10:27,520 --> 00:10:39,320
+learning rate بس المهم ان الوزن الجديد ايه
+
+126
+00:10:39,320 --> 00:10:43,320
+شو ساوي الوزن الحالي الوزن الجديد يعني ايه ايش
+
+127
+00:10:43,320 --> 00:10:46,940
+يعني الوزن اللي هيكون في ال iteration القادمة ساوي
+
+128
+00:10:46,940 --> 00:10:52,600
+الوزن الحالي زائد حاصل ضرب ال input مضروب في ال
+
+129
+00:10:52,600 --> 00:10:54,300
+error مضروب في ال
+
+130
+00:10:57,110 --> 00:11:02,030
+الألفة المصبوط الألفة اللي هي learning rate هذا
+
+131
+00:11:02,030 --> 00:11:08,470
+الكلام من عمل للوزن تبع X1 ومن عمل أيضا للوزن تبع
+
+132
+00:11:08,470 --> 00:11:17,810
+X2 وإذا في كمان other inputs من عمل إلهم كلهم
+
+133
+00:11:17,810 --> 00:11:25,110
+خلّيني
+
+134
+00:11:25,110 --> 00:11:31,110
+أشوف مثلًا عملي على هذا الكلاملو انا فيها اندي ال
+
+135
+00:11:31,110 --> 00:11:38,150
+truth function تبع ال end تعرف ال end بيناقيها two
+
+136
+00:11:38,150 --> 00:11:44,490
+values او two binary values والoutput تبعهم او ال
+
+137
+00:11:44,490 --> 00:11:53,670
+end تبعهم زي
+
+138
+00:11:53,670 --> 00:11:59,810
+هي انا ال truth table تبعend operation انت الآن
+
+139
+00:11:59,810 --> 00:12:06,650
+تتبع ان X1 و X2 هم ال inputs اللي بيدخلهم على ال
+
+140
+00:12:06,650 --> 00:12:11,310
+Perceptron و ال Perceptron وظيفته ان يتعلم اللحظة
+
+141
+00:12:11,310 --> 00:12:14,830
+ما بينهم ال end relationship ما بينهم و دايما
+
+142
+00:12:14,830 --> 00:12:19,190
+يعطيني ال output بالشكل هذا احنا و احنا في عملية
+
+143
+00:12:19,190 --> 00:12:23,430
+التدريب هندخله ال inputs وندخله ال desired output
+
+144
+00:12:24,520 --> 00:12:29,340
+هو لأنه عندما يأخذ ال input ويحسبه إذا طلع ال
+
+145
+00:12:29,340 --> 00:12:33,560
+output اللي حسبه مخالف لهذا الكلام يبقى فيه error
+
+146
+00:12:33,560 --> 00:12:41,700
+في error اللي هو بيعدل على مين بيعدل عليهش على
+
+147
+00:12:41,700 --> 00:12:46,080
+الأوزان الأوزان هذه بيزيد أو تنقص ال iteration
+
+148
+00:12:46,080 --> 00:12:50,420
+اللي بعدها بيدخله ال input اللي بعده وبيكرر
+
+149
+00:12:50,420 --> 00:12:54,330
+العملية هذا الكلام احنا بنعمله مش بس أربع مراتممكن
+
+150
+00:12:54,330 --> 00:12:59,710
+نقيلها على قد أشواط كل أشواط ندخله الأربع هدولة
+
+151
+00:12:59,710 --> 00:13:04,410
+مرة أخرى يعني زي هيك مش عارف إذا كان واضح هذي ال
+
+152
+00:13:04,410 --> 00:13:10,810
+slide ولا لا بس أنت بص عليها و تخيل أو بص على
+
+153
+00:13:10,810 --> 00:13:16,670
+الرسم هذه ال epoch هي مجموعة iterations مجموعة
+
+154
+00:13:16,670 --> 00:13:19,470
+iterations هاي هذه iteration iteration iteration
+
+155
+00:13:19,470 --> 00:13:25,850
+في ال iteration واحدة ندخله إيش؟بتدخله أيضا
+
+156
+00:13:25,850 --> 00:13:30,490
+desired output الأوزان
+
+157
+00:13:30,490 --> 00:13:34,190
+هذه بتكون عملها initialization عشوائي random
+
+158
+00:13:34,190 --> 00:13:39,910
+variables يعني هنا مثلا بناء على الجدول هذه ال W1
+
+159
+00:13:39,910 --> 00:13:49,190
+كانت 0.3 هذا ال initial value تبع W1 و ال W2 كان
+
+160
+00:13:49,190 --> 00:13:49,530
+ايش
+
+161
+00:13:52,610 --> 00:14:01,710
+نقص 0 نقص 0.1 صح لا الهدف نشوف احنا نحسبها ايش ال
+
+162
+00:14:01,710 --> 00:14:06,750
+input؟ Zero صح Zero Zero في ال iteration الأولى ال
+
+163
+00:14:06,750 --> 00:14:11,330
+input Zero Zero ثم رح نضغط بال Zero هذا في ال
+
+164
+00:14:11,330 --> 00:14:13,350
+weight وال Zero هذا في ال weight ونجمع طبعا مبين
+
+165
+00:14:13,350 --> 00:14:20,510
+ان المجموع Zero Zero هذا اللي هو ال total ال sum
+
+166
+00:14:20,830 --> 00:14:28,170
+تبع XI مضروب في Wi يساوي 0 يعني هذا مقارنة بال
+
+167
+00:14:28,170 --> 00:14:28,670
+threshold
+
+168
+00:14:50,640 --> 00:14:57,060
+فاشلو قلّي أن θ يساوي 0 أه خلّيني بس أطلّع ال
+
+169
+00:14:57,060 --> 00:15:12,460
+slide تبعتها طيب
+
+170
+00:15:12,460 --> 00:15:17,040
+okay 0 طب إيش معنى ذلك الكلام
+
+171
+00:15:33,810 --> 00:15:38,710
+أيه ال output اللي هيطلع؟ إذا كان أنا المجموعة تبع
+
+172
+00:15:38,710 --> 00:15:41,970
+ال zero و ال threshold تبع ال zero هيطلع ال output
+
+173
+00:15:41,970 --> 00:15:46,930
+one ولا plus one؟ one ولا .. one ولا zero؟ ال
+
+174
+00:15:46,930 --> 00:15:51,150
+output يعني طلع ال actual output طلع ال zero لأنه
+
+175
+00:15:51,150 --> 00:15:54,790
+لازم يبقى ال output لازم يبقى ال sum أكبر من zero
+
+176
+00:15:54,790 --> 00:16:00,650
+عشان يطلع one المطالبة أنه less than or equalلأ
+
+177
+00:16:00,650 --> 00:16:03,610
+للـ threshold الـ threshold اللي هو قلنا هنا أن θ
+
+178
+00:16:03,610 --> 00:16:12,270
+بساوي 0 طالما أن ال sum هذا طلع يساوى 0 في ال
+
+179
+00:16:12,270 --> 00:16:17,270
+output اللي حيطلع على 0 هذا ال actual output و من
+
+180
+00:16:17,270 --> 00:16:20,430
+ال desired output هاي ال desired output فيهم فرق؟
+
+181
+00:16:20,430 --> 00:16:23,770
+لأ مافيش فرق يبقى ال error zero يتعدى ليش على
+
+182
+00:16:23,770 --> 00:16:30,720
+الأوزان؟ لأ و يبقى الأوزان زمهية الانهذا الكلام في
+
+183
+00:16:30,720 --> 00:16:33,380
+الliterature الأولى الliterature الثانية ماهو ال
+
+184
+00:16:33,380 --> 00:16:38,100
+input اللي هيدخل ال input هذا واحد و ال zero نفس
+
+185
+00:16:38,100 --> 00:16:48,040
+الشيء و ليه مش نفس الشيء واحد هينضرب في ايش
+
+186
+00:16:48,040 --> 00:16:51,900
+واحد
+
+187
+00:16:51,900 --> 00:16:57,640
+هينضرب في ال zero point تلاتة و ال zero هينضرب في
+
+188
+00:16:57,640 --> 00:17:05,890
+ال output التانياللي هو 0.1 إيش هيطلع المجموع؟ 0.3
+
+189
+00:17:05,890 --> 00:17:12,930
+OK خلّيني أشوف أن أنا بتتأكد أن ال threshold احنا
+
+190
+00:17:12,930 --> 00:17:15,590
+الآن بناء على هذا الكلام زي كده ال threshold بيصير
+
+191
+00:17:15,590 --> 00:17:21,510
+0 إحنا عندنا 0.3 0
+
+192
+00:17:21,510 --> 00:17:25,410
+.3 المفروض تعطيني إيش threshold؟ إيش تعطيني
+
+193
+00:17:25,410 --> 00:17:34,380
+output؟ تعطيني واحدةأعطينا واحد لأن الـ 0.3 أكبر
+
+194
+00:17:34,380 --> 00:17:38,420
+منه دعونا نشوف ال step function اللي بيستخدمها ال
+
+195
+00:17:38,420 --> 00:17:53,160
+step
+
+196
+00:17:53,160 --> 00:17:59,000
+function اللي بيستخدمها إذا
+
+197
+00:18:01,030 --> 00:18:06,310
+طلعت واحد ولا سفر؟ طلعت سفر لل threshold إذا أكبر
+
+198
+00:18:06,310 --> 00:18:12,570
+من أو تساوي زيرو بيطلع واحد فإلا بيطلع زيرو بس أنا
+
+199
+00:18:12,570 --> 00:18:18,070
+كده مانتبقش على ال table ال table أنتم معايا واضحة
+
+200
+00:18:18,070 --> 00:18:22,830
+أن المشكلة المشكلة أنه لما أنا بدأ أجي أحسب واحد
+
+201
+00:18:22,830 --> 00:18:29,270
+ضرب 0.3 ايش بيطلع؟0.3 بجمعها على الـ 0 هدا بطلع 0
+
+202
+00:18:29,270 --> 00:18:32,390
+.3 الـ 0.3 هدا أكبر من الـ 0 المفروض يطلع لـ
+
+203
+00:18:32,390 --> 00:18:38,970
+output 1 فهنا ال output إيش اللي نطلع الـ 0.1 لتحت
+
+204
+00:18:38,970 --> 00:18:43,790
+الـ 0.1 لتحت الـ 0.1 لتحت الـ 0.1 لتحت الـ 0.1
+
+205
+00:18:43,790 --> 00:18:54,210
+لتحت الـ 0.1 لتحت الـ 0.1 لتحت الـ 0.1 لتحت
+
+206
+00:18:54,210 --> 00:19:02,460
+الـ 0.1هكذا اصبحت مظبوط انا جربت ال one x واحد
+
+207
+00:19:02,460 --> 00:19:07,160
+واكس اثنين صح؟ Zero ضارب Zero point ثلاث بيطلع
+
+208
+00:19:07,160 --> 00:19:16,280
+Zero وهذا واحد ضارب سالب واحد وعشرة بيطلع سالب
+
+209
+00:19:16,280 --> 00:19:20,460
+مظبوط؟
+
+210
+00:19:20,460 --> 00:19:26,520
+فهكذا بيطلع Zero بيطلع أكبر Zeroبطلع ال output 0
+
+211
+00:19:26,520 --> 00:19:30,640
+فمرة تانية مرة تانية ال input اللى بدخل فى ال
+
+212
+00:19:30,640 --> 00:19:33,100
+iteration ال input اللى بدخل فى ال iteration
+
+213
+00:19:33,100 --> 00:19:38,400
+التانية هو 0 لل X1 و 1 لل X2 بنضربه كل واحد فى
+
+214
+00:19:38,400 --> 00:19:43,960
+الوزن تبعه وبطلع المجموع ناقص أو سالف 0.1 هذا
+
+215
+00:19:43,960 --> 00:19:51,400
+بيطلعلي output 0 مظبوط ال output 0 هذا زى و زى ال
+
+216
+00:19:51,400 --> 00:19:56,350
+desired output فبطلع في ال share نفس ال shareلما
+
+217
+00:19:56,350 --> 00:20:01,070
+ندّه في iteration تلاتة بيكون وضع عندي زيك واجدها
+
+218
+00:20:01,070 --> 00:20:08,530
+بيطلع عندي plus 0.3 plus 0.3 بيوقيني a calculated
+
+219
+00:20:08,530 --> 00:20:13,850
+output of one ال one هذا مخالف لل ash لل desired
+
+220
+00:20:13,850 --> 00:20:17,030
+والفرق ما بينهم ناقص واحد لإن احنا بنجيب ال
+
+221
+00:20:17,030 --> 00:20:21,410
+desired ناقص ال actual او ال calculated فبطلع ال
+
+222
+00:20:21,410 --> 00:20:24,770
+difference سالب واحد هذا ال difference اللي هو ال
+
+223
+00:20:24,770 --> 00:20:31,900
+errorالان ترتب على تعديل الأوزان ايه معادلة تعديل
+
+224
+00:20:31,900 --> 00:20:37,140
+الأوزان اللى طلعنا عليها ان
+
+225
+00:20:37,140 --> 00:20:43,380
+ال W I
+
+226
+00:20:43,380 --> 00:20:47,180
+لإتراشن
+
+227
+00:20:47,180 --> 00:20:56,350
+القادمة WI لإتراشن الحاليةزائد Alpha مضروبة في X
+
+228
+00:20:56,350 --> 00:21:04,910
+الوزن الحالي مضروبة في X الوزن الحالي مضروبة في X
+
+229
+00:21:04,910 --> 00:21:10,350
+الوزن
+
+230
+00:21:10,350 --> 00:21:12,250
+الحالي مضروبة في X الوزن الحالي مضروبة في X الوزن
+
+231
+00:21:12,250 --> 00:21:15,250
+الحالي مضروبة في X الوزن الحالي مضروبة في X الوزن
+
+232
+00:21:15,250 --> 00:21:16,330
+الحالي مضروبة في X الوزن الحالي مضروبة في X الوزن
+
+233
+00:21:16,330 --> 00:21:16,890
+الحالي مضروبة في X الوزن الحالي مضروبة في X الوزن
+
+234
+00:21:16,890 --> 00:21:17,810
+الحالي مضروبة في X الوزن الحالي مضروبة في X الوزن
+
+235
+00:21:17,810 --> 00:21:20,690
+الحالي مضروبة في X الوزن الحالي مضروبة في X الوزن
+
+236
+00:21:20,690 --> 00:21:27,690
+الحالألفة نتعامل معها لإنها 0.2 ألفة
+
+237
+00:21:27,690 --> 00:21:31,070
+بالساوية 0.2 وهذا تقولنا إيش اسمه ال learning rate
+
+238
+00:21:31,070 --> 00:21:34,990
+اللي هان بدنا نشوف أثر كبر أو زغر هذا الرقم على
+
+239
+00:21:34,990 --> 00:21:42,830
+عملية التعليم بس قدامي فعلا 0.2 مضروف في إيش ال
+
+240
+00:21:42,830 --> 00:21:50,570
+input الحالي واحد مضروف في البزن الحالي اللي هو 0
+
+241
+00:21:50,570 --> 00:21:59,230
+.3صح يساوي 0.3 زائد لأ انا اللطف مش الوزن ال error
+
+242
+00:21:59,230 --> 00:22:05,890
+صح ال error ال
+
+243
+00:22:05,890 --> 00:22:15,310
+error اللي هو قداش ال error ال ناقص صح مظبوط يبقى
+
+244
+00:22:15,310 --> 00:22:20,410
+يبقى
+
+245
+00:22:20,410 --> 00:22:20,510
+ايه
+
+246
+00:22:33,890 --> 00:22:46,490
+مرة تانية واحدة معجلة wi plus one ساوى السابق زاد
+
+247
+00:22:46,490 --> 00:22:46,930
+ال delta
+
+248
+00:22:54,390 --> 00:22:59,130
+هذه دلتا دلتا
+
+249
+00:22:59,130 --> 00:23:05,710
+هي مقرار الزيادة احسبها كتابي بساوية ال alpha ضرب
+
+250
+00:23:05,710 --> 00:23:09,450
+ال X انا
+
+251
+00:23:09,450 --> 00:23:12,590
+ببدأ اختصر ال P هي اللي بختصرها انا ببدأ اضرب ال E
+
+252
+00:23:12,590 --> 00:23:20,230
+ايه بمصبوط هيك او لا لأ هذه لحالة هيك البعد الزائد
+
+253
+00:23:20,230 --> 00:23:32,830
+هو دلتا نفسه صحماذا قبل أن نقول هو X1-1 X1
+
+254
+00:23:32,830 --> 00:23:43,870
+-1 X1-1 X1-1 X1
+
+255
+00:23:43,870 --> 00:24:00,680
+-1 X1-1 X1-1لأن اجمعه على الـ 0.3 بيطلع 0.1 لماذا
+
+256
+00:24:00,680 --> 00:24:07,500
+0.1؟
+
+257
+00:24:07,500 --> 00:24:15,420
+المفروض 0.2 نتأكد مرة تانية لأن السابق كان 0.3
+
+258
+00:24:15,420 --> 00:24:27,670
+السابق كان 0.3الـ 0.2 بالسابق فيطلع 0.1 بالموجة
+
+259
+00:24:27,670 --> 00:24:36,370
+فهناك شيء غلط فهناك شيء غلط دعونا نتأكد أن حسبة
+
+260
+00:24:36,370 --> 00:24:51,900
+هذا كمية سليمة هنا الـ W2 W2 P plus 1 السابقة 0لأ
+
+261
+00:24:51,900 --> 00:24:59,060
+ناقص 0.1 و ال delta هي عبارة عن ال
+
+262
+00:24:59,060 --> 00:25:06,260
+alpha هي 0.2 مضروف في ايش مضروف في ال x اللي هي 0
+
+263
+00:25:06,260 --> 00:25:11,660
+مضروف في ال error كل هذا بيطلع zero و بيبقى زي ما
+
+264
+00:25:11,660 --> 00:25:16,460
+هي وهذا صحيح ماشي مع الجدول ايش الغلط اللي عندنا
+
+265
+00:25:16,460 --> 00:25:26,290
+هنا اللي خلّها بتطلع معاناالزي ال واحد هذا غلط هذا
+
+266
+00:25:26,290 --> 00:25:31,190
+مش زي ال jet white ايش السبب انك حضرت واحد X انه
+
+267
+00:25:31,190 --> 00:25:34,830
+ايه حضرت معوض على X واحد انت بتاعت معوض عليها في
+
+268
+00:25:34,830 --> 00:25:38,710
+سفر ماهي واحد ايه X واحد واحد طب ايه معوض تاعت
+
+269
+00:25:38,710 --> 00:25:43,170
+عليها في سفر وين انا موراها هذا لا هذا لا X اتنين
+
+270
+00:25:43,170 --> 00:25:48,570
+هذا لا الوزن التاني احنا الان نحصل في الوزن الاول
+
+271
+00:25:49,600 --> 00:25:54,300
+وزن الأول حسبنا طلع معنا 0.1 هو المفروض في الجدول
+
+272
+00:25:54,300 --> 00:26:02,420
+0.2 اه المفروض يطلع .. احنا حسبنا كان السابق الوزن
+
+273
+00:26:02,420 --> 00:26:06,520
+السابق 0.3 مظبوط إضافة إلى ال delta ال delta هي
+
+274
+00:26:06,520 --> 00:26:11,320
+عبارة عن ال learning rate احتمال ال learning rate
+
+275
+00:26:11,320 --> 00:26:16,480
+مش 0.2 احتمال يكون 0.1 بس انا غلطان خليني اتأكد ان
+
+276
+00:26:16,480 --> 00:26:20,460
+ال learning rate هوهي مالهاش الا هيك هي مالهاش الا
+
+277
+00:26:20,460 --> 00:26:29,880
+انه ال ال alpha بساوي 0.1 طيب
+
+278
+00:26:29,880 --> 00:26:33,880
+لو أخدها على أنها 0.1 بيطلع مظبوط صح؟ بيطلع point
+
+279
+00:26:33,880 --> 00:26:37,620
+two خلاص
+
+280
+00:26:37,620 --> 00:26:41,740
+ماشي هي حتما هيك بس أنا بدور عليها عشان أتأكد مش
+
+281
+00:26:41,740 --> 00:26:42,320
+شايفها
+
+282
+00:27:04,770 --> 00:27:09,930
+بنكمل الآن هنا زي ما انت شايفين جدول لما بدأنا ال
+
+283
+00:27:09,930 --> 00:27:13,770
+iteration جديدة بدأت الأوزان معانا على الأوزان
+
+284
+00:27:13,770 --> 00:27:18,810
+الجديدة صح لأ فرق الأوزان الجديدة هي محل الأوزان
+
+285
+00:27:18,810 --> 00:27:28,890
+الجديدة 0.2 هنا أو نقص 0.1تحت next name حسبنا الان
+
+286
+00:27:28,890 --> 00:27:33,790
+هيطلع ال actual و ال desired غير عن بعض ال error
+
+287
+00:27:33,790 --> 00:27:39,630
+واحد نقص زيرو يسوى واحد واحد الان بماذا؟ بموجة
+
+288
+00:27:39,630 --> 00:27:48,050
+احسب الأوزان الجديدة لأ w واحد w واحد iteration
+
+289
+00:27:48,050 --> 00:27:55,660
+هذه رقم أربع صح بساوي الأوزان تبعد بساوي الالوزن
+
+290
+00:27:55,660 --> 00:28:01,040
+السابق في iteration رقم تلاتة لأ احنا نحصل على رقم
+
+291
+00:28:01,040 --> 00:28:05,080
+خمسة نحصل عزيزي على رقم خمسة كده كانت في الرقم
+
+292
+00:28:05,080 --> 00:28:12,680
+أربعة زائن ايش مضروف بالألفة اي 0.1 مضروف بال X اي
+
+293
+00:28:12,680 --> 00:28:21,000
+واحد مضروف بال error اللي هو واحد صح؟ اذا كده كانت
+
+294
+00:28:21,000 --> 00:28:26,590
+هذه في iteration أربعة كانت 0.2زائد الان جديش هذا
+
+295
+00:28:26,590 --> 00:28:38,410
+المفضل ايش هطلع نصبوت نصبوت لما نحسب وزن w2 لل
+
+296
+00:28:38,410 --> 00:28:47,670
+iteration الجاية بالساوي 0.2 نفسك لأ مش 0.2 w2
+
+297
+00:28:47,670 --> 00:28:59,240
+في iteration 4 زائد ايش نفس الاشي صح0.1 المضروب في
+
+298
+00:28:59,240 --> 00:29:05,980
+واحد ال input كان واحد وال error واحد كده ايه درجة
+
+299
+00:29:05,980 --> 00:29:15,560
+2؟ سالب واحد سالب واحد ساعد 0.1 زائد 0.1 يعني ساوة
+
+300
+00:29:15,560 --> 00:29:20,780
+صفر صح؟ صح اتلا معناك مظبوط ال error الجديد ال
+
+301
+00:29:20,780 --> 00:29:25,870
+weight الجديدهذا الكلام الآن ايش اللي بيحصل ان
+
+302
+00:29:25,870 --> 00:29:32,370
+تدريجيا الأوزان هذه بدأت على ال initial weights
+
+303
+00:29:32,370 --> 00:29:39,790
+كانت 0.3 مع نقطة 0.1 تدريجيا تبدأ تتغير إلى أن في
+
+304
+00:29:39,790 --> 00:29:46,950
+الآخر تستقر عمليا بدأت تستقر من هنا بدأت تستقر
+
+305
+00:29:46,950 --> 00:29:51,650
+الأوزانIteration هو إترايش مابيحصل أي تغيير هدف حد
+
+306
+00:29:51,650 --> 00:29:59,850
+ذاته مؤشر على إن ال Perceptron بطل يعمل Errors صح
+
+307
+00:29:59,850 --> 00:30:05,930
+بقوله بقى بطل يعمل Errors أوزانه تبعته ثبتت و
+
+308
+00:30:05,930 --> 00:30:13,830
+دايما ال desired مطابق لل actual و إتر نقدر نقول
+
+309
+00:30:13,830 --> 00:30:19,070
+إن ال Perceptron اتعلم ال Perceptronاتعلم اتعلم
+
+310
+00:30:19,070 --> 00:30:27,010
+ايش اتعلم انه يعطيني ال output الصحيح ل ال end
+
+311
+00:30:27,010 --> 00:30:31,490
+function لما اعطيله two inputs بيعطيني ال end
+
+312
+00:30:31,490 --> 00:30:36,310
+تبعهم هذا مثال بسيط جدا انا مش محتاج اجيب
+
+313
+00:30:36,310 --> 00:30:40,670
+perceptron و اعلمه علشان احسب ال end gate او ال
+
+314
+00:30:40,670 --> 00:30:44,830
+end function صح ولا لأ if zero and zero بطلع ال
+
+315
+00:30:44,830 --> 00:30:50,280
+zeroF one and one بطلها one otherwise بطلها zero
+
+316
+00:30:50,280 --> 00:30:54,520
+كلها F statement واحد مظبوط بس احنا هذا الكلام
+
+317
+00:30:54,520 --> 00:30:59,480
+مشينا فيه عشان نوضح فكرة او نوضح قالية تعاملهم في
+
+318
+00:30:59,480 --> 00:31:03,060
+ال Perceptron القالية هذه هي اللي بنبنى عليها تبع
+
+319
+00:31:03,060 --> 00:31:07,280
+ال Perceptron هي اللي بنبنى عليهاالتعلم في الشبكة
+
+320
+00:31:07,280 --> 00:31:11,200
+شبكة من ال perceptrons اللي هي نور ال network يعني
+
+321
+00:31:11,200 --> 00:31:14,860
+نور ال network هي عبارة عن شبكة من ال perceptrons
+
+322
+00:31:14,860 --> 00:31:18,740
+هذه و بتشتغل بنفس القليل انه perceptron الواحد في
+
+323
+00:31:18,740 --> 00:31:27,060
+هذه الشبكة الشبكة ممكن تبقى زي هيك و هيك كل واحد
+
+324
+00:31:27,060 --> 00:31:30,640
+من الدلائل هذه هي عبارة عن perceptron فنسميه
+
+325
+00:31:30,640 --> 00:31:35,020
+neuron بالبسيط كل واحد منهم زي ما انت شايفبدخل
+
+326
+00:31:35,020 --> 00:31:39,460
+عليه مجموعة input و بطلع منه مجموعة output ال
+
+327
+00:31:39,460 --> 00:31:42,900
+output في واقع الأمر هم ال duplicates يعني هو نفس
+
+328
+00:31:42,900 --> 00:31:49,100
+ال output هو بطلع output واحد بس بتعمم يعني هذا ال
+
+329
+00:31:49,100 --> 00:31:55,340
+neuron بطلع منه نفس ال output بس بتعمم على مين على
+
+330
+00:31:55,340 --> 00:32:00,840
+كل ال neurons اللي في المرحلة اللي بعد اللي في
+
+331
+00:32:00,840 --> 00:32:08,650
+الطبقة اللي بعدهاكل واحد من هذول نسميهم layer هذي
+
+332
+00:32:08,650 --> 00:32:10,890
+الأخيرة بيسميها output layer لإن هي اللي بيطلع
+
+333
+00:32:10,890 --> 00:32:15,250
+فيها ال output و هذي بيسميها ال input layer و هذول
+
+334
+00:32:15,250 --> 00:32:19,490
+التانين اللي في المصدر بيسميهم hidden layers ال
+
+335
+00:32:19,490 --> 00:32:25,370
+input layer عمليا هذول المربعات دي ماهياش neurons
+
+336
+00:32:25,370 --> 00:32:30,090
+الدوية بس ال neurons ايش يعني مش neuronsالمقاربعات
+
+337
+00:32:30,090 --> 00:32:33,710
+يعني ما بتعملش summation ولا بتعمل activation ولا
+
+338
+00:32:33,710 --> 00:32:39,450
+بتعمل أي اشي بس مجرد نقطة تشعب ال input فيها بتوزع
+
+339
+00:32:39,450 --> 00:32:47,350
+على هم هدول الدوائر هم اللي بيعملوا ال weighted
+
+340
+00:32:47,350 --> 00:32:51,670
+sum وال activation ال calculation هنا ال
+
+341
+00:32:51,670 --> 00:32:56,010
+activation أصبحت عبارة عن مقارنة ال sum بال
+
+342
+00:32:56,010 --> 00:33:00,120
+thresholdبنطلع ال output بناء على هذا المقارنة
+
+343
+00:33:00,120 --> 00:33:04,460
+فالان بدأ ارجع انا قبل ما نفهم قالية عمل ال
+
+344
+00:33:04,460 --> 00:33:07,680
+network ككل بدأ ارجع على مفهوم ال activation
+
+345
+00:33:07,680 --> 00:33:12,480
+function احنا شوفنا ال step لما كنا بنقول بنقارن
+
+346
+00:33:12,480 --> 00:33:20,360
+بال zero كان هذا الكلام جاي
+
+347
+00:33:20,360 --> 00:33:26,310
+من هنا هذول الأربعةيعني بقى أربع أنواع من ال
+
+348
+00:33:26,310 --> 00:33:30,050
+activation functions ال activation functions بتاكل
+
+349
+00:33:30,050 --> 00:33:35,730
+X كابيتل هذا هو ال sum هو ال sum اي sum ال
+
+350
+00:33:35,730 --> 00:33:40,830
+weighted sum تبع حاصل جمع مضاريب ال inputs في
+
+351
+00:33:40,830 --> 00:33:46,490
+أوزانها صح الكلام حاصل جمع مضاريب ال inputs في
+
+352
+00:33:46,490 --> 00:33:50,430
+أوزانها بيطلع عندي ال weighted sum بالان على ال
+
+353
+00:33:50,430 --> 00:33:54,520
+sum هذا و بالان على ال thresholdالـ function بتطلع
+
+354
+00:33:54,520 --> 00:33:57,380
+هذه ال output هذه اسمها step function كيف ال
+
+355
+00:33:57,380 --> 00:34:00,400
+output تبعها اللي هو احنا شفناه أتابعه في المثال
+
+356
+00:34:00,400 --> 00:34:06,100
+إذا X X capital اللي هي ال weighted sum أكبر من أو
+
+357
+00:34:06,100 --> 00:34:11,540
+تساوي ال zero تعطيني one أقل تعطيني ال zero هذه ال
+
+358
+00:34:11,540 --> 00:34:15,200
+function اسمها ال sine function زي ال step زي ال
+
+359
+00:34:15,200 --> 00:34:21,650
+step بس ال output تبعها مش 01 سالب one و plus oneو
+
+360
+00:34:21,650 --> 00:34:24,870
+برضه نفس الشيء إذا كان ال X أكبر من أسفل 0
+
+361
+00:34:24,870 --> 00:34:30,470
+فبتعطيني plus one و إلا تعطيني negative one في
+
+362
+00:34:30,470 --> 00:34:33,670
+حاجة اسمها segment function segment function هذه
+
+363
+00:34:33,670 --> 00:34:39,750
+معادلة sum نحط السنة فوق الأبسلون فوق ال E و ال
+
+364
+00:34:39,750 --> 00:34:44,250
+output هنا الآن بيطلع رقم عشري مش عشري مش binary
+
+365
+00:34:44,250 --> 00:34:48,410
+هذوله binary ده صح هذوله binary ال output ال Y هنا
+
+366
+00:34:48,740 --> 00:34:51,480
+يا إما بيجي وانا zero يا إما بيجي plus one أو
+
+367
+00:34:51,480 --> 00:34:56,560
+minus one أنا 110 و ال linear نفس اللي بدخل عليها
+
+368
+00:34:56,560 --> 00:35:02,480
+بتطلعلي مقابله value إحنا الآن يا إما في الامترال
+
+369
+00:35:02,480 --> 00:35:05,560
+اللي قدام يا إما بتكون ال activation function step
+
+370
+00:35:05,560 --> 00:35:10,960
+أو sign أو sigmoid خليني
+
+371
+00:35:10,960 --> 00:35:14,200
+أنا أطلع على لو أنا عندي مش perceptron واحد عندي
+
+372
+00:35:14,200 --> 00:35:17,740
+network من ال من ال neurons
+
+373
+00:35:21,350 --> 00:35:25,870
+بالمثال هذا أعطيك فكرة لإيش ممكن تستخدم نور ال
+
+374
+00:35:25,870 --> 00:35:30,890
+network أو ال perceptron انت اتبر ان هدولة انكس
+
+375
+00:35:30,890 --> 00:35:35,010
+الان vectors
+
+376
+00:35:35,010 --> 00:35:40,370
+و ال vectors هذه عندي هنا في الحالة هذه X1 و X2
+
+377
+00:35:40,370 --> 00:35:46,430
+لكن تخيل ممكن تبقى خمسة X's X1, X2, X3, X4, X5 و
+
+378
+00:35:46,430 --> 00:35:47,330
+ال vectors هذه
+
+379
+00:35:51,610 --> 00:35:58,290
+رقم هنا إيه معنى إيه دلالة ال network اتعلمت إنها
+
+380
+00:35:58,290 --> 00:36:01,390
+لما تشوف فائدة تعطينا output هذا لما تشوف فائدة
+
+381
+00:36:01,390 --> 00:36:04,350
+تعطينا output هذا لما تشوف input هذا تعطينا output
+
+382
+00:36:04,350 --> 00:36:10,080
+هذاهذا ما نسميه classification انه يدخل عليها
+
+383
+00:36:10,080 --> 00:36:15,000
+input input vector وهي بتصنف ليه ينتمي إلى هذا
+
+384
+00:36:15,000 --> 00:36:19,960
+الفئة أو هذا الفئة جامعة ال zero او جامعة ال one
+
+385
+00:36:19,960 --> 00:36:23,540
+جامعة ال zero هيكون لهم دلالة معينة وجامعة ال one
+
+386
+00:36:23,540 --> 00:36:28,080
+لهم دلالة معينة اخرى فال neural network عادة
+
+387
+00:36:28,080 --> 00:36:30,880
+مستخدم في التصنيف نعطيها vectors و ال vectors هذه
+
+388
+00:36:30,880 --> 00:36:34,420
+لها معنى مثلا بنقول انه أنا مجموع من الأشخاص
+
+389
+00:36:34,730 --> 00:36:39,930
+الاشخاص هذا احنا عنا الخصائص تبعتهم، بقول مثلا طول
+
+390
+00:36:39,930 --> 00:36:44,810
+الشخص ووزن الشخص، عمر الشخص وما إلى ذلك، ونعطيها
+
+391
+00:36:44,810 --> 00:36:50,170
+ميت شخص كل واحد إله إيش الفئام تبعته، و هي بتتعلم
+
+392
+00:36:50,170 --> 00:36:55,510
+تصنيفهم، إن والله هدول الأشخاص ذكور، هدولها إنث،
+
+393
+00:36:55,510 --> 00:36:59,650
+بناء على التدريب اللي احنا بندربله، بنقولهم ..
+
+394
+00:36:59,650 --> 00:37:04,840
+بنقولها إنه .. كل شخص بنقولها إنه إيشهو ذاكر ولا
+
+395
+00:37:04,840 --> 00:37:10,120
+أنثى بعد ما تتدرب وتخلص نسألها عن أي شخص جديد فهي
+
+396
+00:37:10,120 --> 00:37:17,600
+بتعرف اذا كان التصنيف تبعه ذاكر ولا أنثى الان بدنا
+
+397
+00:37:17,600 --> 00:37:21,040
+نشوف اللي هو ال multi-layer Perceptron اللي هو
+
+398
+00:37:21,040 --> 00:37:24,560
+الكلام اللي طلعناه قبل قليل شوية وكيف قالية العمل
+
+399
+00:37:24,560 --> 00:37:30,080
+مثل هذا النوع من ال networks لاحظ انه
+
+400
+00:37:34,600 --> 00:37:39,840
+لحظ أنه لو أحنا مدنيين خلّيني أخد مثال أبسط منها
+
+401
+00:37:39,840 --> 00:37:43,700
+ده يعني ناخد مثال في network تحتوي على hidden
+
+402
+00:37:43,700 --> 00:37:50,280
+layer واحدة زي hidden hidden layer واحدة هذا input
+
+403
+00:37:50,280 --> 00:37:56,200
+layer وهذا hidden layer وهذا output layer الان لو
+
+404
+00:37:56,200 --> 00:37:59,820
+أنت جيت فكرت في هذا الكلام تلاقي أن في أحنا مشكلة
+
+405
+00:37:59,820 --> 00:38:05,240
+وهي إيشالـ neurons اللي هنا اللي على ال output
+
+406
+00:38:05,240 --> 00:38:11,500
+layer لما انا بده ادخل ال input هدخل معاه ال
+
+407
+00:38:11,500 --> 00:38:16,680
+desired output تمام
+
+408
+00:38:16,680 --> 00:38:24,060
+هدخل ال desired الـ desired YD 1 YD 2 YD K YD L
+
+409
+00:38:24,060 --> 00:38:31,220
+الان كل واحد من هدول ال neurons اللي هنا هتقدر
+
+410
+00:38:31,220 --> 00:38:36,170
+تحسب ال errorما بين ال output اللى طلعته وما بين
+
+411
+00:38:36,170 --> 00:38:51,930
+ال output ال actual صح ولا لأ كمان
+
+412
+00:38:51,930 --> 00:38:56,830
+حاصر الفرق ما بينهم هو ايش ال error المشكلة هنا
+
+413
+00:38:56,830 --> 00:39:03,940
+هذه ال node في ال hidden layerما عندهم أي فكرة عنه
+
+414
+00:39:03,940 --> 00:39:09,400
+كdesire يعني مانعرفش هو ييجي يحسب الفرق ما بين ال
+
+415
+00:39:09,400 --> 00:39:13,000
+output تبعه وما بين ال desire هو مش مسئول عن ال
+
+416
+00:39:13,000 --> 00:39:15,400
+desire ده ده اللي مسئول عن ال desire هو مسئول
+
+417
+00:39:15,400 --> 00:39:20,560
+مسئولية جزئية okay فاحنا الآن بنشوف كيف هدول ال
+
+418
+00:39:20,560 --> 00:39:24,560
+nodes يعني هدول ال nodes اللي هنا بيحسموا الفرق أو
+
+419
+00:39:24,560 --> 00:39:28,200
+ال error و بناء على ال error هم بيعدلوا أوزان مين
+
+420
+00:39:30,620 --> 00:39:35,580
+بعد الأوزان مين ال input اللي داخل عليه كل واحدة
+
+421
+00:39:35,580 --> 00:39:39,200
+بيسوي الكلام هذا بشكل مباشر بس الجماعة اللي هنا
+
+422
+00:39:39,200 --> 00:39:54,300
+ايش بيبيسويها أنا كده بشوفه بتفسيري لان هذا
+
+423
+00:39:54,300 --> 00:39:55,720
+عبارة عن ايش multi layer
+
+424
+00:40:04,570 --> 00:40:11,110
+بتفشر من ورا ال network طبعا
+
+425
+00:40:11,110 --> 00:40:15,270
+ال initialization لما نتعامل مع network هبنعمل
+
+426
+00:40:15,270 --> 00:40:19,150
+initialization برضه عشوائي لمن الأوزان تبع ال
+
+427
+00:40:19,150 --> 00:40:25,070
+inputs يعني كل واحدة من ال nodes هذه ال node هي ال
+
+428
+00:40:25,070 --> 00:40:29,330
+inputs تبعونها بنعملها كل واحد منهم ايش أوزان
+
+429
+00:40:29,330 --> 00:40:35,930
+فالأوزان هذه بتبقى بشكل عشوائيأو موزع بالتساوي كيف
+
+430
+00:40:35,930 --> 00:40:43,570
+يعني يعني عندي range هنا FI is the total number of
+
+431
+00:40:43,570 --> 00:40:47,950
+inputs of neuron I يعني عندي نيرون أنا هذا الرقم
+
+432
+00:40:47,950 --> 00:40:53,630
+واحد أكمل inputs عليه أربعة صح كلهم دولة واحد
+
+433
+00:40:53,630 --> 00:40:57,110
+اتنين تلاتة كلهم داخل عليهم أربعة inputs فالوزان
+
+434
+00:40:57,110 --> 00:41:05,630
+تبعتهم يقول two point four على أربعة يساوي ستة0.6
+
+435
+00:41:05,630 --> 00:41:12,850
+0.6 بالموجة و 0.6 بالسائق يعني تخلي الأرزان تبعتك
+
+436
+00:41:12,850 --> 00:41:19,650
+تتروح من بين 0.6 إلى 0.6 بتوزع هذا ال range هذا ال
+
+437
+00:41:19,650 --> 00:41:25,790
+range كده طوله 1.2 دسم ال 1.2 هذا بالتساوي إلى
+
+438
+00:41:25,790 --> 00:41:30,510
+أربع قيم متساوي
+
+439
+00:41:34,040 --> 00:41:36,620
+هذه اللي هو ال initialization لأن ال activation
+
+440
+00:41:36,620 --> 00:41:41,280
+تختار activation function عادة مش هتختار في مسألة
+
+441
+00:41:41,280 --> 00:41:47,620
+الامتحان هيقولك استخدم ال sigmoid او استخدم ال
+
+442
+00:41:47,620 --> 00:41:52,120
+step او استخدم ال sign function ايش معناه ذلك؟
+
+443
+00:41:52,120 --> 00:41:58,020
+معناه ذلك انه لما تحسب الصم اللي هو دايما الصم هذا
+
+444
+00:41:58,020 --> 00:42:02,800
+هو اقع عن حاصل جمع ash المضاري المضروب كل input
+
+445
+00:42:02,800 --> 00:42:12,260
+بال ashبالوزن تبعه هتحسبها و تقسم منهم ال theta ال
+
+446
+00:42:12,260 --> 00:42:17,000
+threshold تبعنا و ال output هذا و ال total هذا
+
+447
+00:42:17,000 --> 00:42:22,640
+تدخلوا على seed mode عشان تطلع ال Y ال Y تبع انهي
+
+448
+00:42:22,640 --> 00:42:27,060
+node تبع ال node اللي انت واقف عليه هنا Yj يعني
+
+449
+00:42:27,060 --> 00:42:28,360
+node من ال nodes تبع ال
+
+450
+00:42:33,540 --> 00:42:38,860
+الـ middle layer YK يعني node من الـ node سبعة الـ
+
+451
+00:42:38,860 --> 00:42:42,540
+output layer أضحك؟ لحظة إن هو .. إيش هنا .. إيش
+
+452
+00:42:42,540 --> 00:42:47,200
+قال؟ على طول أخد ال .. ال sum و طرح منه ال
+
+453
+00:42:47,200 --> 00:42:52,040
+threshold okay ال output .. الفرق ما بين ال .. ال
+
+454
+00:42:52,040 --> 00:42:54,480
+sum و ال threshold هو اللي مدخل على ال segment
+
+455
+00:42:54,480 --> 00:43:00,980
+okay طيب بعدين هذه .. هذه الخطوة مسمى activation
+
+456
+00:43:00,980 --> 00:43:06,310
+activation اللي بينتج عنهابينتج عنها هي ال
+
+457
+00:43:06,310 --> 00:43:09,930
+calculated output بعد ما نحسب ال calculated output
+
+458
+00:43:09,930 --> 00:43:18,130
+لان نود ايش بنسوي نشوف اذا في error ولا لأ صح okay
+
+459
+00:43:18,130 --> 00:43:24,990
+نشوف اذا في error ولا لأ اذا
+
+460
+00:43:24,990 --> 00:43:28,910
+في error معناه ذلك اننا نعمل update للأوزان مافيش
+
+461
+00:43:28,910 --> 00:43:35,900
+error مافيش update للأوزان updating الأوزان للالـ
+
+462
+00:43:35,900 --> 00:43:40,600
+output neurons مختلف
+
+463
+00:43:40,600 --> 00:43:48,380
+عن updating الأوزان لمين للـ hidden neurons تذكر
+
+464
+00:43:48,380 --> 00:43:54,260
+أن في عندي أحناير hidden layer هنا
+
+465
+00:43:54,260 --> 00:43:58,560
+output layer ال
+
+466
+00:43:58,560 --> 00:43:59,420
+output neurons
+
+467
+00:44:04,110 --> 00:44:08,550
+هو ايش اللي حاسب ال error و لا ال error اللي هو
+
+468
+00:44:08,550 --> 00:44:13,750
+عبارة عن ايش الفرق بين ال desire ناقص ال
+
+469
+00:44:13,750 --> 00:44:20,090
+attraction مظبوط هذا ال error بين حسب يدخل في حسبة
+
+470
+00:44:20,090 --> 00:44:28,210
+ال error gradient هذه ايش هذه الإشارة delta صح
+
+471
+00:44:28,210 --> 00:44:32,610
+small delta هذا delta capital وهذا delta small
+
+472
+00:44:38,190 --> 00:44:48,290
+خلاص بعد ذلك بقى اضربه في الـ alpha ثم في ال
+
+473
+00:44:48,290 --> 00:44:53,650
+output بيطلع معايا ايه
+
+474
+00:44:53,650 --> 00:45:01,420
+ال delta وهذا ال capital وهذا ال small تمامالان
+
+475
+00:45:01,420 --> 00:45:04,820
+حسبت انا small delta اللى هى ال error gradient
+
+476
+00:45:04,820 --> 00:45:09,500
+باخد ال error gradient باضربه فى ال output ال
+
+477
+00:45:09,500 --> 00:45:15,180
+actual مبروه فى ال learning rate ال alpha بطلع
+
+478
+00:45:15,180 --> 00:45:18,920
+معاى ال delta يعنى مقدار التغير اللى بيطرق على
+
+479
+00:45:18,920 --> 00:45:23,340
+الوزن هذا المقدار التغير بنضيفه على الوزن السابق
+
+480
+00:45:23,340 --> 00:45:28,950
+بنضيفه على الوزن السابق هذه مقدار التغيربنضيفه على
+
+481
+00:45:28,950 --> 00:45:32,550
+الوزن السابق و بطلع معاه الوزن الجديد و أضح
+
+482
+00:45:32,550 --> 00:45:37,990
+العملية تلات خطوات الآن عملية تغيير الأوزان عملية
+
+483
+00:45:37,990 --> 00:45:42,150
+تغيير الأوزان أولا بحسب ال error gradient ثم بحسب
+
+484
+00:45:42,150 --> 00:45:48,990
+ال error delta او ال weight delta اه بيظهر تغير في
+
+485
+00:45:48,990 --> 00:45:51,810
+الوزن ثم بضيفه على الوزن الحالي
+
+486
+00:45:57,230 --> 00:46:00,450
+خلّي بالك إنه لو مافيش قرر هيطلع هذا المقدار الـ 0
+
+487
+00:46:00,450 --> 00:46:04,350
+كله هذا هيطلع الـ 0 كله هذا الـ 0 كله هيطلع هذا
+
+488
+00:46:04,350 --> 00:46:08,210
+الـ 0 كله هيطلع هذا الـ 0 كله هيطلع هذا الـ 0 كله
+
+489
+00:46:08,210 --> 00:46:08,970
+هيطلع هذا الـ 0 كله هيطلع هذا الـ 0 كله هيطلع هذا
+
+490
+00:46:08,970 --> 00:46:09,290
+هيطلع هذا الـ 0 كله هيطلع هذا الـ 0 كله هيطلع هذا
+
+491
+00:46:09,290 --> 00:46:10,050
+الـ 0 كله هيطلع هذا الـ 0 كله هيطلع هذا الـ 0 كله
+
+492
+00:46:10,050 --> 00:46:11,390
+هيطلع هذا الـ 0 كله هيطلع هذا الـ 0 كله هيطلع هذا
+
+493
+00:46:11,390 --> 00:46:21,430
+الـ 0 كله هيطلع هذا الـ 0 كله هيطلع
+
+494
+00:46:21,430 --> 00:46:29,990
+هذا الـ 0 كلههذا الأمر بالنسبة لـ output neurons
+
+495
+00:46:29,990 --> 00:46:35,210
+يعني الـ neurons لاحظ ال subscript الـ K هذه تتبع
+
+496
+00:46:35,210 --> 00:46:46,910
+مين زي ما في الرسم هنا الـ K اللي هم هدولة تفضل
+
+497
+00:46:46,910 --> 00:46:51,530
+اللي هو error gradient بعدين ال weight correction
+
+498
+00:46:51,530 --> 00:46:56,960
+اللي دلت ال weight و بعدين ال weight اللي جديدهذا
+
+499
+00:46:56,960 --> 00:47:14,500
+بالنسبة لـ L أما بالنسبة للـ Hidden Layer الوزن
+
+500
+00:47:14,500 --> 00:47:20,620
+الـ Delta K هذه تحتفظ فيها لأنها تدخل معنا في حسب
+
+501
+00:47:20,620 --> 00:47:25,980
+التعديل الأوزان على الـ Hidden كيف؟ يعني دي أنا
+
+502
+00:47:26,810 --> 00:47:31,790
+error gradient للـhidden
+
+503
+00:47:31,790 --> 00:47:36,590
+small delta g small delta g هو نفس الشيء إبراهن
+
+504
+00:47:36,590 --> 00:47:50,290
+output النوت نحن
+
+505
+00:47:50,290 --> 00:47:50,690
+الآن هنا
+
+506
+00:47:59,160 --> 00:48:03,820
+لأن الواحدة من هدولة لو ال input تبعها اتعمم على
+
+507
+00:48:03,820 --> 00:48:08,380
+مين على كل ال nodes اللي في ال layer اللي بقت يعني
+
+508
+00:48:08,380 --> 00:48:12,420
+بمعنى others هدول ال nodes كانوا أخطأوا كان عندهم
+
+509
+00:48:12,420 --> 00:48:17,760
+errors فهذا بفعل أوزانهم و بفعل ال input اللي
+
+510
+00:48:17,760 --> 00:48:22,220
+أجرهم من ورا يعني هدول ال nodes اللي هنا مسئولين
+
+511
+00:48:22,220 --> 00:48:27,460
+مسئولية جزئية عن الخطأ اللي بيحصل إذا حصل خطأ في
+
+512
+00:48:27,460 --> 00:48:32,430
+ال hidden صح؟وبالتالي احنا بدنا نرجع بعض المسئولية
+
+513
+00:48:32,430 --> 00:48:40,210
+عليهم هاي بعض المسئولية small delta k هدا هاد ال
+
+514
+00:48:40,210 --> 00:48:43,950
+node كل واحدة من هدولها حسبة ال small delta k
+
+515
+00:48:43,950 --> 00:48:49,150
+تبعها ولا لأ صح ولا لأ ارجع التاني ال error
+
+516
+00:48:49,150 --> 00:48:52,690
+gradient هدا احنا الان رجعنا على ال output مش كل
+
+517
+00:48:52,690 --> 00:48:55,950
+واحدة منهم تحسب ال small delta k تبعها small delta
+
+518
+00:48:55,950 --> 00:49:01,930
+k تبعها اللي هو ال error gradientالان بدى نضرب في
+
+519
+00:49:01,930 --> 00:49:09,610
+ال errors نضرب في الأوزان تبع كل ال inputs اللى
+
+520
+00:49:09,610 --> 00:49:15,850
+دخل عليها هذا لما انا اقول wjk ايش يعني يعني الوزن
+
+521
+00:49:15,850 --> 00:49:20,570
+اللى تبع ال input اللى طالع اللى رايح على k من j
+
+522
+00:49:20,570 --> 00:49:30,040
+يعني هى وزن و هى وزن و هى وزن و هى وزنكل واحد من
+
+523
+00:49:30,040 --> 00:49:34,260
+هؤلاء الأوزاد سينضرب في Delta K Delta K هي Error
+
+524
+00:49:34,260 --> 00:49:41,300
+Gradient تبع هذا ال node سينضرب في ماذا؟ في WJK
+
+525
+00:49:41,300 --> 00:49:48,240
+وينجمع الكلام هذا كله هذا الكلام يعني Error تبعها
+
+526
+00:49:48,240 --> 00:49:56,840
+جاء بسبب كل ال nodes اللي غذوها هذا الكلام ينضرب
+
+527
+00:49:57,370 --> 00:50:04,830
+لأن لما تحسب الـ delta J تبعتها تضرب ال output
+
+528
+00:50:04,830 --> 00:50:12,450
+تبعها مضم في واحد نقص output هذا يعني Y²-Y صح او
+
+529
+00:50:12,450 --> 00:50:18,970
+لأ انا بسطط اتخذ ال YJ مضم في واحد ومضم في YJ يعني
+
+530
+00:50:18,970 --> 00:50:29,180
+Y-YJ² صحهذا النقطة ينضرب في مجموعة الصميشن هذه
+
+531
+00:50:29,180 --> 00:50:34,300
+عشان نحصل على ال error gradient تبع هذا ال node
+
+532
+00:50:34,300 --> 00:50:39,920
+ونكرر الكلام هذا كله لل other nodes عندما حصلنا
+
+533
+00:50:39,920 --> 00:50:43,340
+على هذا كلام لل node نرجع تاني بنفس القالي اللي
+
+534
+00:50:43,340 --> 00:50:48,040
+حسبنا فيها الوزن جديد لل output node نعمل نفس
+
+535
+00:50:48,040 --> 00:50:51,710
+الشيء اللي هو باخد الالـ error gradient بضربه في
+
+536
+00:50:51,710 --> 00:50:53,850
+اللي دخل على ال node و بضربه في ال learning rate
+
+537
+00:50:53,850 --> 00:50:58,790
+بطلع ال delta w بجمع ال delta w على ال w الحالي
+
+538
+00:50:58,790 --> 00:51:06,370
+بطلع معايا ال ash الوزع الجديد هذا الكلام بينكرره
+
+539
+00:51:06,370 --> 00:51:11,250
+مرة مرتين تلاتة إلى ان ال node بتتعلم ال network
+
+540
+00:51:11,250 --> 00:51:15,430
+بتتعلم ايش يعني بتتعلم يعني ال error السابعة هتصبح
+
+541
+00:51:15,430 --> 00:51:22,290
+صفر هضرب جهة ان شاء اللهبنطلع على الكلام هذا بشكل
+
+542
+00:51:22,290 --> 00:51:27,070
+يعني مفصل بالأرقام خلاصة الأمر أنه احنا الأن بدنا
+
+543
+00:51:27,070 --> 00:51:31,630
+نفهم شغل أساسي وهي أنه لما يكون عندي perceptron
+
+544
+00:51:31,630 --> 00:51:38,850
+يعني نورون واحد قليل العمل تبعته أو ال learning ال
+
+545
+00:51:38,850 --> 00:51:41,770
+learning technique تبعته واحدة هي تعديل الأوزان
+
+546
+00:51:41,770 --> 00:51:45,950
+بناء على الفرق ما بين ال actual output و ال
+
+547
+00:51:45,950 --> 00:51:52,660
+desired outputبيبقى معطيله في أثناء عملية التدريب
+
+548
+00:51:52,660 --> 00:51:56,000
+وهذا المقصود بال learning أو supervised learning
+
+549
+00:51:56,000 --> 00:52:00,880
+supervised learning يعني نعطيه input و مع كل input
+
+550
+00:52:00,880 --> 00:52:04,760
+بنقوله ايش ال output الصحيح اللي المفروض يطلع و
+
+551
+00:52:04,760 --> 00:52:10,200
+بنشغل عملية ال iterations مرة و مرة عشان يضبط
+
+552
+00:52:10,200 --> 00:52:14,540
+الأوزان تبعته تدريجيا إلى أن تصبح الأوزان stable
+
+553
+00:52:14,540 --> 00:52:18,140
+stable يعني ما بقي تتمشي على تغييريا ما لا تمشي
+
+554
+00:52:18,140 --> 00:52:22,060
+عليها تغيير بالمرة، يا ما التغيير أصبح طفيف بالقدر
+
+555
+00:52:22,060 --> 00:52:26,820
+اللي نقدر نقنشه، يعني واحد في الألف مثلا، إجمالي
+
+556
+00:52:26,820 --> 00:52:32,060
+الـSum تبع كل الـErrors، تبع كل الـNodes، لما يبقى
+
+557
+00:52:32,060 --> 00:52:35,580
+عندي نورة Network، يعني زي هيك، ويبقى فيها Hidden
+
+558
+00:52:35,580 --> 00:52:40,940
+Layers، العملية بدأت تتحركعلى جزءين عملية تعديل
+
+559
+00:52:40,940 --> 00:52:43,780
+الأوزانة أو عملية ال learning بتتصير على جزءين جزء
+
+560
+00:52:43,780 --> 00:52:48,280
+الأول بتتعلق بتعديل انه ال output nodes للأوزان
+
+561
+00:52:48,280 --> 00:52:53,440
+تبعتها وهذا بعد ذلك يترحى العالمين على ال hidden
+
+562
+00:52:53,440 --> 00:53:01,140
+nodes اللي هم عدّوا الأوزان تبعتهم هذا اسمه ان ال
+
+563
+00:53:01,140 --> 00:53:04,300
+input signals تبشي في هذا الاتجاهو ال error of
+
+564
+00:53:04,300 --> 00:53:07,320
+signals ال input data بتمشي في هذا الاتجاه و ال
+
+565
+00:53:07,320 --> 00:53:10,240
+error of data بتمشي في هذا الاتجاه هذه بتروح ال
+
+566
+00:53:10,240 --> 00:53:14,100
+error of data اللي جابلها علشان قمامة اذا في layer
+
+567
+00:53:14,100 --> 00:53:17,880
+واحدة او اكتر في ال hidden علشان كل واحدة اتعدل
+
+568
+00:53:17,880 --> 00:53:23,080
+الأوزان تبعتها okay ستة مثال ان شاء الله المحاضرة
+
+569
+00:53:23,080 --> 00:53:26,320
+تجيبني نشوفهم و بعدين بنشوف كيف عمليت التعلم
+
diff --git a/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/sr95xI0GDlQ_raw.json b/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/sr95xI0GDlQ_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..eb7b6bf8cdb582ff96719b11eaf7e12b4d0930e6
--- /dev/null
+++ b/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/sr95xI0GDlQ_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 5033, "start": 20.69, "end": 50.33, "text": "بسم الله الرحمن الرحيم اليوم ان شاء الله بنكمل محاضراتنا في موضوع ال search و استخدامه في الذكاء الاصطناعي اخر محاضرة كنا حكينا في ال a star algorithm ال a star algorithm و كنا برضه حكينا قبلها ل greedy algorithm قولنا الفرق كان هو ان ال a star algorithm بتزيد حاجة بسيطة لها مفعول في ال optimality الحالة البسيطة هذه ايش؟", "tokens": [3555, 38251, 21984, 34892, 5016, 27842, 34892, 5016, 32640, 45595, 20498, 16472, 13412, 16606, 21984, 44945, 24793, 1211, 3714, 5016, 46958, 2288, 9307, 8315, 8978, 3714, 2407, 11242, 45367, 2423, 3164, 4032, 44713, 9778, 3215, 10943, 3224, 8978, 32545, 4117, 16606, 2423, 33546, 9566, 8315, 3615, 1829, 1975, 34740, 3714, 5016, 46958, 25720, 9122, 8315, 11331, 4117, 1829, 8315, 8978, 2423, 257, 3543, 9284, 2423, 257, 3543, 9284, 4032, 9122, 8315, 4724, 43042, 3224, 11331, 4117, 1829, 8315, 12174, 36150, 11296, 5296, 28228, 9284, 12174, 12610, 8315, 27188, 2288, 4587, 25961, 31439, 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0.9462890625}, {"start": 2407.94, "end": 2408.36, "word": " هدولة", "probability": 0.7039794921875}, {"start": 2408.36, "end": 2408.96, "word": " الـF", "probability": 0.89404296875}, {"start": 2408.96, "end": 2409.46, "word": " تبعها", "probability": 0.9521484375}], "temperature": 1.0}, {"id": 86, "seek": 243842, "start": 2411.42, "end": 2438.42, "text": "ال H دايما موطن او انت لا بتحسبها ال H في مسائل .. في مسائل .. في مسائل بتكون موطن في مسائل اخرى انا ممكن اجي اطلب منك بس مجرد انك انت تقترح اكتر من heuristic و اقولك اعطيني تقييمك مين منهم ممكن يكون افضل في عنده مسألة بدي اعطيكوا هي homework و تجربوا فيها و تشوفوا ايش بطلع معاك", "tokens": [6027, 389, 11778, 47302, 15042, 3714, 2407, 9566, 1863, 1975, 2407, 16472, 2655, 20193, 39894, 5016, 35457, 11296, 2423, 389, 8978, 47524, 16373, 1211, 4386, 8978, 47524, 16373, 1211, 4386, 8978, 47524, 16373, 1211, 39894, 30544, 3714, 2407, 9566, 1863, 8978, 47524, 16373, 1211, 1975, 34740, 7578, 1975, 8315, 3714, 43020, 1975, 7435, 1829, 1975, 9566, 46152, 9154, 4117, 4724, 3794, 3714, 7435, 2288, 3215, 16472, 4117, 16472, 2655, 6055, 38149, 2288, 5016, 1975, 4117, 2655, 2288, 9154, 415, 374, 3142, 4032, 1975, 39648, 4117, 1975, 3615, 9566, 9957, 1829, 6055, 38436, 32640, 4117, 3714, 9957, 9154, 16095, 3714, 43020, 7251, 30544, 1975, 5172, 11242, 1211, 8978, 43242, 3224, 47524, 10721, 37977, 4724, 16254, 1975, 3615, 9566, 1829, 4117, 14407, 39896, 14578, 4032, 6055, 7435, 25513, 14407, 8978, 11296, 4032, 6055, 8592, 38688, 14407, 1975, 1829, 8592, 4724, 9566, 1211, 3615, 20449, 995, 4117], "avg_logprob": -0.23211206403271906, "compression_ratio": 1.8888888888888888, "no_speech_prob": 1.1324882507324219e-06, "words": [{"start": 2411.42, "end": 2411.84, "word": "ال", "probability": 0.28515625}, {"start": 2411.84, "end": 2412.0, "word": " H", "probability": 0.42578125}, {"start": 2412.0, "end": 2412.48, "word": " دايما", "probability": 0.767333984375}, {"start": 2412.48, "end": 2412.84, "word": " موطن", "probability": 0.59503173828125}, {"start": 2412.84, "end": 2412.96, "word": " او", "probability": 0.6075439453125}, {"start": 2412.96, "end": 2413.04, "word": " انت", "probability": 0.819580078125}, {"start": 2413.04, "end": 2413.12, "word": " لا", "probability": 0.583984375}, {"start": 2413.12, "end": 2413.7, "word": " بتحسبها", "probability": 0.9488525390625}, {"start": 2413.7, "end": 2414.26, "word": " ال", "probability": 0.62646484375}, {"start": 2414.26, "end": 2414.62, "word": " H", "probability": 0.95556640625}, {"start": 2414.62, "end": 2416.06, "word": " في", "probability": 0.93896484375}, {"start": 2416.06, "end": 2416.4, "word": " مسائل", "probability": 0.9402669270833334}, {"start": 2416.4, "end": 2416.98, "word": " ..", "probability": 0.290771484375}, {"start": 2416.98, "end": 2417.18, "word": " في", "probability": 0.74267578125}, {"start": 2417.18, "end": 2417.46, "word": " مسائل", "probability": 0.9168294270833334}, {"start": 2417.46, "end": 2417.46, "word": " ..", "probability": 0.2578125}, {"start": 2417.46, "end": 2417.56, "word": " في", "probability": 0.93359375}, {"start": 2417.56, "end": 2417.86, "word": " مسائل", "probability": 0.9876302083333334}, {"start": 2417.86, "end": 2418.16, "word": " بتكون", "probability": 0.9384765625}, {"start": 2418.16, "end": 2418.56, "word": " موطن", "probability": 0.9644775390625}, {"start": 2418.56, "end": 2418.82, "word": " في", "probability": 0.2313232421875}, {"start": 2418.82, "end": 2419.96, "word": " مسائل", "probability": 0.98486328125}, {"start": 2419.96, "end": 2420.52, "word": " اخرى", "probability": 0.80419921875}, {"start": 2420.52, "end": 2420.76, "word": " انا", "probability": 0.87890625}, {"start": 2420.76, "end": 2421.0, "word": " ممكن", "probability": 0.9833984375}, {"start": 2421.0, "end": 2421.32, "word": " اجي", "probability": 0.84033203125}, {"start": 2421.32, "end": 2421.74, "word": " اطلب", "probability": 0.9578450520833334}, {"start": 2421.74, "end": 2422.12, "word": " منك", "probability": 0.992919921875}, {"start": 2422.12, "end": 2422.42, "word": " بس", "probability": 0.982666015625}, {"start": 2422.42, "end": 2422.8, "word": " مجرد", "probability": 0.981689453125}, {"start": 2422.8, "end": 2423.04, "word": " انك", "probability": 0.87451171875}, {"start": 2423.04, "end": 2423.34, "word": " انت", "probability": 0.840087890625}, {"start": 2423.34, "end": 2424.36, "word": " تقترح", "probability": 0.989990234375}, {"start": 2424.36, "end": 2425.1, "word": " اكتر", "probability": 0.9755859375}, {"start": 2425.1, "end": 2425.24, "word": " من", "probability": 0.99462890625}, {"start": 2425.24, "end": 2425.86, "word": " heuristic", "probability": 0.6397705078125}, {"start": 2425.86, "end": 2426.58, "word": " و", "probability": 0.8408203125}, {"start": 2426.58, "end": 2426.94, "word": " اقولك", "probability": 0.9090169270833334}, {"start": 2426.94, "end": 2427.66, "word": " اعطيني", "probability": 0.8521484375}, {"start": 2427.66, "end": 2428.5, "word": " تقييمك", "probability": 0.9063720703125}, {"start": 2428.5, "end": 2428.74, "word": " مين", "probability": 0.917724609375}, {"start": 2428.74, "end": 2429.18, "word": " منهم", "probability": 0.9716796875}, {"start": 2429.18, "end": 2429.54, "word": " ممكن", "probability": 0.982177734375}, {"start": 2429.54, "end": 2429.98, "word": " يكون", "probability": 0.99365234375}, {"start": 2429.98, "end": 2430.88, "word": " افضل", "probability": 0.951904296875}, {"start": 2430.88, "end": 2431.36, "word": " في", "probability": 0.7255859375}, {"start": 2431.36, "end": 2432.12, "word": " عنده", "probability": 0.578369140625}, {"start": 2432.12, "end": 2433.02, "word": " مسألة", "probability": 0.93701171875}, {"start": 2433.02, "end": 2433.2, "word": " بدي", "probability": 0.390380859375}, {"start": 2433.2, "end": 2433.54, "word": " اعطيكوا", "probability": 0.8714192708333334}, {"start": 2433.54, "end": 2433.66, "word": " هي", "probability": 0.1456298828125}, {"start": 2433.66, "end": 2434.2, "word": " homework", "probability": 0.61328125}, {"start": 2434.2, "end": 2435.78, "word": " و", "probability": 0.681640625}, {"start": 2435.78, "end": 2437.04, "word": " تجربوا", "probability": 0.9742431640625}, {"start": 2437.04, "end": 2437.32, "word": " فيها", "probability": 0.995361328125}, {"start": 2437.32, "end": 2437.44, "word": " و", "probability": 0.7626953125}, {"start": 2437.44, "end": 2437.72, "word": " تشوفوا", "probability": 0.9967041015625}, {"start": 2437.72, "end": 2437.84, "word": " ايش", "probability": 0.7568359375}, {"start": 2437.84, "end": 2438.12, "word": " بطلع", "probability": 0.60626220703125}, {"start": 2438.12, "end": 2438.42, "word": " معاك", "probability": 0.7615559895833334}], "temperature": 1.0}, {"id": 87, "seek": 244501, "start": 2439.99, "end": 2445.01, "text": "أه بتخليها home work على البيت يعنى، منعطيكم العشاء", "tokens": [10721, 3224, 39894, 9778, 20292, 11296, 1280, 589, 15844, 2423, 21292, 2655, 37495, 1863, 7578, 12399, 9154, 3615, 9566, 1829, 24793, 18863, 8592, 16606], "avg_logprob": -0.4765625095367432, "compression_ratio": 0.9885057471264368, "no_speech_prob": 0.0, "words": [{"start": 2439.99, "end": 2440.99, "word": "أه", "probability": 0.6510009765625}, {"start": 2440.99, "end": 2441.65, "word": " بتخليها", "probability": 0.9052734375}, {"start": 2441.65, "end": 2441.87, "word": " home", "probability": 0.381591796875}, {"start": 2441.87, "end": 2442.11, "word": " work", "probability": 0.79052734375}, {"start": 2442.11, "end": 2442.29, "word": " على", "probability": 0.1978759765625}, {"start": 2442.29, "end": 2442.67, "word": " البيت", "probability": 0.9747721354166666}, {"start": 2442.67, "end": 2443.39, "word": " يعنى،", "probability": 0.63800048828125}, {"start": 2443.39, "end": 2444.51, "word": " منعطيكم", "probability": 0.561083984375}, {"start": 2444.51, "end": 2445.01, "word": " العشاء", "probability": 0.6575520833333334}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2446.12925, "duration_after_vad": 2362.6299999999933}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/vaV8_9JJ9Vg_postprocess.srt b/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/vaV8_9JJ9Vg_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..44fb41f0cdb1f418154a0a8efda9383a6f9fe750
--- /dev/null
+++ b/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/vaV8_9JJ9Vg_postprocess.srt
@@ -0,0 +1,1404 @@
+1
+00:00:21,090 --> 00:00:23,390
+بسم الله الرحمن الرحيم المحاضرة هذه ان شاء الله
+
+2
+00:00:23,390 --> 00:00:26,450
+احنا لازال في نفس الإطار اللي هو ال hybrid
+
+3
+00:00:26,450 --> 00:00:29,550
+intelligence systems بس المرة اللي بدنا نشوف
+
+4
+00:00:29,550 --> 00:00:32,330
+المحاضرة هذه و المحاضرة الجاية ان شاء الله بدنا
+
+5
+00:00:32,330 --> 00:00:35,630
+نشوف اللي هو ال evolution .. المحاضرة اللي بدنا
+
+6
+00:00:35,630 --> 00:00:39,590
+نشوف ال evolutionary neural networks يعني من اسمها
+
+7
+00:00:39,590 --> 00:00:43,170
+هي عبارة عن hybrid مابين neural networks و مابين
+
+8
+00:00:43,170 --> 00:00:45,510
+genetic algorithm و المحاضرة اللي بعد ان شاء الله
+
+9
+00:00:45,510 --> 00:00:49,050
+بنشوف fuzzy evolutionary fuzzy evolutionary يعني
+
+10
+00:00:49,050 --> 00:00:53,390
+hybrid مابينال fuzzy logic و مابين ال evolutionary
+
+11
+00:00:53,390 --> 00:00:57,950
+اللي هو ال genetic algorithm okay الان لو بدك تاخد
+
+12
+00:00:57,950 --> 00:01:01,230
+العنوان هذا اللي هو evolutionary نورا بدك تتخيل
+
+13
+00:01:01,230 --> 00:01:05,610
+ايش تتخيل neural network بالاساس زي ما كنا احنا
+
+14
+00:01:05,610 --> 00:01:08,830
+شوفنا في المثالين اللي قبل هيكا اللي هو الدمج ما
+
+15
+00:01:08,830 --> 00:01:13,850
+بين ال neural network و ال rule
+
+16
+00:01:13,850 --> 00:01:17,030
+based و برضه كمان fuzzy و neural network و fuzzy
+
+17
+00:01:17,030 --> 00:01:21,700
+كانهيكالية العامة أو الإطار العام لل system neural
+
+18
+00:01:21,700 --> 00:01:29,380
+ماشي و من .. الآن هنا برضه نفس الشيء أن الإطار
+
+19
+00:01:29,380 --> 00:01:32,860
+العام هو neural network ولكن داخلة عليها ال
+
+20
+00:01:32,860 --> 00:01:37,500
+genetic algorithm من زاوية حد بقدر يتخيل من وين
+
+21
+00:01:37,500 --> 00:01:43,240
+ممكن نيجي نستعين بال genetic algorithm وين بالظبط
+
+22
+00:01:43,240 --> 00:01:44,200
+في ال neural network
+
+23
+00:01:48,440 --> 00:01:55,960
+هذه ال slide يفترض تغششه شوية اللي انت شايفه الأن
+
+24
+00:01:55,960 --> 00:01:59,960
+عبارة عن نور ال network مظبوط نور ال network دي له
+
+25
+00:01:59,960 --> 00:02:07,240
+input تلاتة ال output ليها فيها one node وفيه
+
+26
+00:02:07,240 --> 00:02:14,040
+أربعة في ال middle أو في ال hidden شايف
+
+27
+00:02:14,040 --> 00:02:14,480
+ال chromosome
+
+28
+00:02:19,270 --> 00:02:24,910
+بيعبر عن إيش الكرموزومة بيمثل إيش بيمثل ال weights
+
+29
+00:02:24,910 --> 00:02:28,890
+بس
+
+30
+00:02:28,890 --> 00:02:33,690
+هو ال weights الأوزان بمعنى أخر أنه احنا أصلا
+
+31
+00:02:33,690 --> 00:02:37,770
+المثل الأساسية في neural network لوحدها في neural
+
+32
+00:02:37,770 --> 00:02:41,570
+network لوحدها احنا بنعمل عملية ال training مشان
+
+33
+00:02:41,570 --> 00:02:47,390
+أنه احنا نضبط الأوزان يعني كأنه احنا عملية ال
+
+34
+00:02:47,390 --> 00:02:53,030
+training بحثا عنال best weights الأوزان الأفضل
+
+35
+00:02:53,030 --> 00:02:57,690
+يبقى الأوزان الأفضل هي ال solution اللي احنا بندور
+
+36
+00:02:57,690 --> 00:03:02,390
+عليه صح؟ والأوزان هذه iteration ورا iteration
+
+37
+00:03:02,390 --> 00:03:05,150
+بتبدأ من ال initial وبعدين iteration ورا iteration
+
+38
+00:03:05,150 --> 00:03:12,470
+بتتعدل وصولا إلى الأوزان الأفضل اللي بتعطيني بتخلي
+
+39
+00:03:12,470 --> 00:03:17,990
+ال network تعطيني output صحيحيبقى هذه الأوزان
+
+40
+00:03:17,990 --> 00:03:23,730
+مجموعة الأوزان هي اللي أنا ببحث عنه عمليا طيب هذا
+
+41
+00:03:23,730 --> 00:03:27,210
+الأمر مناسب جدا لل genetic algorithm انه انا اذا
+
+42
+00:03:27,210 --> 00:03:32,790
+عبرت عن الأوزان بشكل chromosome وخلت عملية التعلم
+
+43
+00:03:32,790 --> 00:03:39,950
+اتم evolutionary اتم بال genetic algorithm متخيلين
+
+44
+00:03:39,950 --> 00:03:46,250
+كيف الكلام ممكن يكونهذا جرب خلاصة ماضلش اصلا يعني
+
+45
+00:03:46,250 --> 00:03:50,030
+هو هذا هو هذا في نهاية الأمر الأساس الفكرة اللي
+
+46
+00:03:50,030 --> 00:03:54,610
+على الأساسها بتقوم اللي هو الدمج ما بين ال neural
+
+47
+00:03:54,610 --> 00:04:01,230
+network و ما بين ال genetic algorithm عندنا عمليا
+
+48
+00:04:01,230 --> 00:04:04,930
+التلاتة nodes الأولى هم input nodes صح مالهم مش
+
+49
+00:04:04,930 --> 00:04:09,970
+اوزان ال input بدخل عليهم وهو بتوزن من اللي يلهم
+
+50
+00:04:09,970 --> 00:04:14,910
+اوزان بجيت ال node الأخر انت اربعةو معانا تمانية
+
+51
+00:04:14,910 --> 00:04:19,170
+صح فكل node هنا كل node أربعة أو خمسة أو ستة أو
+
+52
+00:04:19,170 --> 00:04:27,030
+سبعة أو تمانية لها مجموعة من تلت أوزان صح هذه لها
+
+53
+00:04:27,030 --> 00:04:33,770
+أيش أربع أوزان لأنه جايها من أربع nodes فانا الآن
+
+54
+00:04:33,770 --> 00:04:40,190
+الجدول هذا هو بمساطة شديدة تعبير عن ال weight
+
+55
+00:04:40,190 --> 00:04:44,490
+vectorsإنه والله من نود كذا من نود واحد إلى نود
+
+56
+00:04:44,490 --> 00:04:48,890
+واحد طبعا مافيش أوزان يعني كل نود إلى نفسها مافيش
+
+57
+00:04:48,890 --> 00:04:53,870
+شيء عشان أيها أحط أصفر يعني من اتنين إلى واحد،
+
+58
+00:04:53,870 --> 00:04:58,790
+Zero من تلاتة من اتنين إلى يعني عندي المثالثة ده
+
+59
+00:04:58,790 --> 00:05:02,770
+هو اللي بيعطيني الأوزان من أي نود إلى نود الأخرى
+
+60
+00:05:02,770 --> 00:05:06,390
+ماشي في عندي نود مابتعطيش له نوز هو يعني مثلا نود
+
+61
+00:05:06,390 --> 00:05:10,320
+رقم اتنين مابتعطي له تمانية صح؟نوت رقم اتنين
+
+62
+00:05:10,320 --> 00:05:14,800
+مابتعطيها تماما ولا بتعطيها .. لأ بتعطيها الباقين
+
+63
+00:05:14,800 --> 00:05:20,740
+الأخرين مظبوط نوت رقم تلاتة كلهم مضمون مابيعطيها
+
+64
+00:05:20,740 --> 00:05:24,120
+تماما المهم ان هذا ال table .. هذا ال table انا
+
+65
+00:05:24,120 --> 00:05:28,960
+مابدأ انظر الى .. ال table انا مابدأ انظر الى
+
+66
+00:05:28,960 --> 00:05:33,700
+كرمزومات فال chromosome .. ال chromosome هو عبارة
+
+67
+00:05:33,700 --> 00:05:40,480
+عن مجموعة من الاشي ال vectorsماذا يعني فترزل؟ تطلع
+
+68
+00:05:40,480 --> 00:05:42,680
+على الرسم و تطلع على الأرقام اللي جوا في ال
+
+69
+00:05:42,680 --> 00:05:48,860
+chromosome كل واحد من هذول عبارة عن
+
+70
+00:05:48,860 --> 00:05:56,240
+.. صح ولا أنا رقمته مغلط؟ أربعة، أيش هالأربعة؟
+
+71
+00:05:56,240 --> 00:06:00,820
+يعني الأوزان كمان من ال node أربعة خمسة، ستة،
+
+72
+00:06:00,820 --> 00:06:06,780
+سبعة، تمانية، صح؟ صح طيب، بعدين؟ هذول الأوزان ال
+
+73
+00:06:06,780 --> 00:06:12,310
+initial، الابتدائيةماذا نفعل الان نفكر جينيتيكا
+
+74
+00:06:12,310 --> 00:06:16,310
+الحين نفكر جينيتيكا ال algorithm ماببدأش انا
+
+75
+00:06:16,310 --> 00:06:22,910
+بشتغلش على كرمزوم واحد بدي اعمل صفة كرمزومات ولا
+
+76
+00:06:22,910 --> 00:06:28,310
+لأ بدي اعمل generation كامل من كذا n number of
+
+77
+00:06:28,310 --> 00:06:33,510
+chromosomes ولا لأ بعمل من هذا جو ستين خمسين
+
+78
+00:06:33,510 --> 00:06:39,160
+generation كامل بعملمثل هذا .. مش من هذا .. مثل
+
+79
+00:06:39,160 --> 00:06:44,580
+هذا ستين او خمسين او whatever number of random ..
+
+80
+00:06:44,580 --> 00:06:52,600
+random ماشي .. chromosomes و بعدين
+
+81
+00:06:52,600 --> 00:07:02,840
+بدي انتخب .. بدي انتخب مين الأفضل كيف؟
+
+82
+00:07:04,420 --> 00:07:08,100
+العندي الآن اتخيل في عندي ستين واحد من دولة
+
+83
+00:07:08,100 --> 00:07:12,800
+chromosome كل chromosome البنيه تبعته صار واضحه
+
+84
+00:07:12,800 --> 00:07:18,720
+ايه ان كل التلاته دوله كل اول اتناش اول اتناش كل
+
+85
+00:07:18,720 --> 00:07:26,520
+تلاته منهم عباره عن اوزان ال hidden nodes والاربع
+
+86
+00:07:26,520 --> 00:07:31,240
+اخرانيات الاربع genes الاخيرةواضحة ال construction
+
+87
+00:07:31,240 --> 00:07:37,260
+فانا عامل من هذا الكرمزوم كذا number of N هذا ال
+
+88
+00:07:37,260 --> 00:07:44,600
+generation zero من الأبتدائي كرمزوم 1 خليني أقول
+
+89
+00:07:44,600 --> 00:07:52,920
+CH1 يعني كرمزوم 1 لعند CHN إيش الآن بنعمل
+
+90
+00:07:59,050 --> 00:08:06,910
+لنحسب ال fitness صح ولا لا لنحسب
+
+91
+00:08:06,910 --> 00:08:13,170
+ال fitness تبع مين تبع
+
+92
+00:08:13,170 --> 00:08:26,150
+كل كروموزوم لنحسب ال fitness تبعه كيف
+
+93
+00:08:26,150 --> 00:08:30,710
+نحسبطيب أنا مفترض إن أنا في عندي data .. عندي data
+
+94
+00:08:30,710 --> 00:08:35,330
+دخلها هنا و أشوف إيش ال output بالنسبة لها ..
+
+95
+00:08:35,330 --> 00:08:39,310
+عليها بالأوزان و أشوف اللي بطلع ال output و
+
+96
+00:08:39,310 --> 00:08:45,870
+أقارنهم بال desire why مقارنتان بال إيش بال desire
+
+97
+00:08:45,870 --> 00:08:54,430
+okay هل
+
+98
+00:08:54,430 --> 00:08:55,270
+أحسب أنا الآن
+
+99
+00:08:59,410 --> 00:09:04,910
+الفيتنس تبع كل واحد منهم كل واحد منهم بديش الفيتنس
+
+100
+00:09:04,910 --> 00:09:12,550
+تبعه كيف بدي أجيب عندي input vector بدي أجيب input
+
+101
+00:09:12,550 --> 00:09:17,230
+vector صح سيبك من الأقام اللي جوال هذا بدي أجيب
+
+102
+00:09:17,230 --> 00:09:22,370
+input vector x1, x2, x3 و أدخل على ال network على
+
+103
+00:09:22,370 --> 00:09:25,750
+أساس الأوزان و أشوف كده شو بطلع فبطلع عندي ال
+
+104
+00:09:25,750 --> 00:09:30,690
+fitness تبع ال chromosome الأولبعدين اجرب الكرمزوم
+
+105
+00:09:30,690 --> 00:09:36,390
+التاني كيف؟ على نفس ال input صح؟ انا كيف دقيقهم؟
+
+106
+00:09:36,390 --> 00:09:38,930
+دقيقهم على نفس المصطرة المصطرة اللي هي ال input
+
+107
+00:09:38,930 --> 00:09:42,470
+نفسها تشوف مين من هدول ال chromosomes بيعطيني
+
+108
+00:09:42,470 --> 00:09:47,290
+نتيجة أفضل على نفس ال input صح؟ مالفعش هذا الكلام
+
+109
+00:09:47,290 --> 00:09:51,590
+مالفعش على input واحد أنا المفروض عندي صفة inputs
+
+110
+00:09:51,590 --> 00:09:58,130
+صح ولا لأ؟ المفروض عندي اقول60-70 او 100 input
+
+111
+00:09:58,130 --> 00:10:02,570
+بعمل على اساسهم ال testing او ال evaluation فبدي
+
+112
+00:10:02,570 --> 00:10:07,870
+اخد لكل كرمزوم واحد لكل كرمزوم بدي ادخل ال inputs
+
+113
+00:10:07,870 --> 00:10:14,050
+كلهم واحد و لا واحد و لكل input احسب ال error و
+
+114
+00:10:14,050 --> 00:10:19,910
+بعدين اخد ال total error بمعنى ان هذا الكرمزوم
+
+115
+00:10:19,910 --> 00:10:26,170
+الواحد بدي اختبره against كل ال x الانكل ال .. ايه
+
+116
+00:10:26,170 --> 00:10:32,530
+بالضبط كل ال input x1 و x2 لغاية نقول مثلا dhx xm
+
+117
+00:10:32,530 --> 00:10:37,090
+رقم تاني اللي بدنا نستخدم إشارة إلى dhm هنا عدد
+
+118
+00:10:37,090 --> 00:10:46,770
+كإجمالي اللي هو ال data ال test data عندي
+
+119
+00:10:46,770 --> 00:10:50,950
+مثلا meet test data record الكرمزونات لديهم عدد
+
+120
+00:10:50,950 --> 00:10:56,130
+آخر لديهم عدد كرمزونات فانا بدأجي أدخلأختبر هذا
+
+121
+00:10:56,130 --> 00:11:01,710
+الكرمزوم على كل ال data و يطلع معاه single number
+
+122
+00:11:01,710 --> 00:11:07,490
+اللي هو إجمالي ال error إجمالي ال error و نفس
+
+123
+00:11:07,490 --> 00:11:10,590
+الشيء أكرره لكرمزوم التاني و التالتة و الأولى لذلك
+
+124
+00:11:10,590 --> 00:11:14,430
+بقول أنا قيمت الكرمزومات تبع لسه ال generation
+
+125
+00:11:14,430 --> 00:11:20,030
+الأول تمام ؟ بناء على هذا التقييم باخد بكمل
+
+126
+00:11:20,030 --> 00:11:25,080
+الموضوع اللي هو ايش باخد الأصلحةبحسب .. بحسب ال
+
+127
+00:11:25,080 --> 00:11:31,580
+fitness ratio إذا بتذكره خلّيني أجيب ال slide هذي
+
+128
+00:11:31,580 --> 00:11:38,640
+أذكركوا بالعملية كلها مرة واحدة أمام؟ فاحنا دلوقت
+
+129
+00:11:38,640 --> 00:11:46,320
+هاي ال chromosomes .. chromosomes كلها okay
+
+130
+00:11:46,320 --> 00:11:55,470
+لأن كل chromosome منهم كل chromosome منهمبيعطيني
+
+131
+00:11:55,470 --> 00:12:01,630
+ايش بيعطيني كأنه بيعطيني network مختلفة و لا لأ
+
+132
+00:12:01,630 --> 00:12:08,050
+يعني لما انا بحط الأوزان و بعدين بشيلهم و بحط
+
+133
+00:12:08,050 --> 00:12:10,690
+أوزان تاني كأنني عملت network أخرى صح نفس ال
+
+134
+00:12:10,690 --> 00:12:15,470
+topology نفس التوصيل إنما أوزان مختلفة كأنه
+
+135
+00:12:15,470 --> 00:12:19,370
+network مختلفة okay فأنا باختبر كل واحد من ال
+
+136
+00:12:19,370 --> 00:12:24,660
+chromosomes على اللي هو بشكلي networkو بطلع ال
+
+137
+00:12:24,660 --> 00:12:28,540
+fitness ratio تبعه بناء على ال fitness ratio بقصد
+
+138
+00:12:28,540 --> 00:12:34,700
+ال rules علشان هطلع مين اللي بدي أدخلهم و أختار
+
+139
+00:12:34,700 --> 00:12:40,640
+منهم أعملهم cross over مظبوط؟ لأن ال rules هاللي
+
+140
+00:12:40,640 --> 00:12:45,140
+ليش؟ ال rules هاللي ليش؟ عشان أطلع لمين المرشحين
+
+141
+00:12:45,140 --> 00:12:48,840
+اللي أدخلهم على cross over ال cross over إذا
+
+142
+00:12:48,840 --> 00:12:53,900
+بتذكروا باخد أزواجو الأزواج اللى بختارله بختارهم
+
+143
+00:12:53,900 --> 00:12:58,880
+على أساس probability تبع ال crossover صح كل اتنين
+
+144
+00:12:58,880 --> 00:13:01,600
+بيقع عليهم ال probability بتحكملهم عشان يعطيني
+
+145
+00:13:01,600 --> 00:13:07,740
+منهم اتنين تانين كرموسومين تانين بهذا الشكل بأكون
+
+146
+00:13:07,740 --> 00:13:16,960
+ال generation اللى بعده D1 بس لسه في mutation ال
+
+147
+00:13:16,960 --> 00:13:24,230
+mutation مظبوط بس مبدأيا انا جبتالجين التاني ناتج
+
+148
+00:13:24,230 --> 00:13:27,750
+عملية ليهاش ال crossover هذا اللي بقنا معاه في ال
+
+149
+00:13:27,750 --> 00:13:32,050
+crossover او من ال crossover باجر عليه عملية ليهاش
+
+150
+00:13:32,050 --> 00:13:36,850
+ال mutation برضه بختار من اللي بدنا نعمل عليه ال
+
+151
+00:13:36,850 --> 00:13:41,150
+mutation بناء على probability تبع ال mutation PMA
+
+152
+00:13:41,150 --> 00:13:45,530
+و ال mutation ايش معناته معناته ان احنا بدنا نختار
+
+153
+00:13:45,530 --> 00:13:49,710
+واحد من ال genes ارجع تاني هنا
+
+154
+00:13:52,530 --> 00:13:56,650
+الصورة الأصلية واحد من ال genes هذا و هذا و هذا
+
+155
+00:13:56,650 --> 00:14:03,730
+اللي اغيره بشكل عشوائي و ممكن اختار على أساس ان
+
+156
+00:14:03,730 --> 00:14:10,630
+واحد من ال nodes اروح اغير .. يعني هاجأ اقول اللي
+
+157
+00:14:10,630 --> 00:14:13,550
+توقعت على هذه ال node لأن هذه ال node هي اللي بدي
+
+158
+00:14:13,550 --> 00:14:16,570
+اعملها mutation ال mutation يعني اغير كل ال
+
+159
+00:14:16,570 --> 00:14:21,540
+weights اللي فيها اعملهم تغيير عشوائيلان وضحة ال
+
+160
+00:14:21,540 --> 00:14:27,220
+cycle كيف ده تكون وضحة ال cycle انه احنا ال
+
+161
+00:14:27,220 --> 00:14:30,220
+chromosomes اللي عملناهم في البداية لازم نقيمهم
+
+162
+00:14:30,220 --> 00:14:36,020
+نقيمهم كيف بإنه كل واحد منهم بنخضعه على مجموعة ال
+
+163
+00:14:36,020 --> 00:14:39,320
+data اللي عندنا و بنحسب إجمال الإرار هو هذا ال
+
+164
+00:14:39,320 --> 00:14:42,800
+fitness اللي بعده اللي بعده اللي بعده لان بناء على
+
+165
+00:14:42,800 --> 00:14:45,460
+ال fitness هذه بنحسب ال fitness ratio و بناء على
+
+166
+00:14:45,460 --> 00:14:50,950
+ال fitness ratio نقارنه مين اللي ناخدهعشان نعمل
+
+167
+00:14:50,950 --> 00:14:54,810
+crossover نخدهم أزواج اللي بيقع عليهم الاختيار
+
+168
+00:14:54,810 --> 00:14:58,250
+الأزواج و بنشكل منهم بال crossover اللي هو ال
+
+169
+00:14:58,250 --> 00:15:03,510
+children اللي بيجي هنا بعد كده بنقرر مين منهم
+
+170
+00:15:03,510 --> 00:15:07,490
+ينعمل عليه mutation مبينا على ال mutation
+
+171
+00:15:07,490 --> 00:15:11,310
+probability او probability of mutation صار عندي
+
+172
+00:15:11,310 --> 00:15:17,290
+جيل جديد ايش بسويه بعيد الكرة وهي بقيمهم
+
+173
+00:15:19,700 --> 00:15:23,680
+بناء على نفس ال data طبعا مش هجيب data set مختلف
+
+174
+00:15:23,680 --> 00:15:29,040
+لكل generation صح ماكنتش
+
+175
+00:15:29,040 --> 00:15:35,220
+بقى أوقف خلاص
+
+176
+00:15:35,220 --> 00:15:41,660
+لما أصل ل generation ألاقي فيه chromosomes و ما هو
+
+177
+00:15:41,660 --> 00:15:47,850
+أكتر ال error تبعه جمال ال error تبعه قريب منأو
+
+178
+00:15:47,850 --> 00:15:52,810
+نزل عن ال threshold اللي انا حددته تمام اما ال
+
+179
+00:15:52,810 --> 00:15:57,090
+zero او واحد في الألف او واحد في العشر تلاف او
+
+180
+00:15:57,090 --> 00:16:01,270
+جداش ال threshold تمام اللي هو التقييم تبعه صار
+
+181
+00:16:01,270 --> 00:16:06,970
+منخفض جدا اه يعني ال error أسف ال error تبعه صار
+
+182
+00:16:06,970 --> 00:16:13,890
+منخفض جدا لدرجة اللي انا جابله في هذا الحالة ال
+
+183
+00:16:13,890 --> 00:16:18,050
+chromosome الواحد يمثل ايه؟يمثل مجموعة الأوزان
+
+184
+00:16:18,050 --> 00:16:22,850
+النهائية اللى بدنا نثبتها على ال network أصبحت ال
+
+185
+00:16:22,850 --> 00:16:27,730
+network ما بتتعلم بقالية الاش ال delta وال error
+
+186
+00:16:27,730 --> 00:16:31,050
+correction و الكلام هذا صح لا back propagation ولا
+
+187
+00:16:31,050 --> 00:16:35,170
+غيره تتعلم بقالية الاش ال genetic learning ال
+
+188
+00:16:35,170 --> 00:16:39,250
+genetic learning بمعنى ان احنا بتعدل أوزانها من
+
+189
+00:16:39,250 --> 00:16:41,530
+خلال ال .. بشكل evolutionary
+
+190
+00:16:47,150 --> 00:17:04,750
+بس هيك بس
+
+191
+00:17:04,750 --> 00:17:08,170
+هيك هذا هو المدخل الوحيد اللي هو ان احنا ممكن ندمج
+
+192
+00:17:08,170 --> 00:17:13,910
+من خلاله مابين او نستفيد من خلاله مابين من ال
+
+193
+00:17:13,910 --> 00:17:18,520
+genetic algorithm في neural networkماذا هو المدخل
+
+194
+00:17:18,520 --> 00:17:22,760
+هذا هو عملية تعديل الأوزان ممكن نستفيد من حاجة
+
+195
+00:17:22,760 --> 00:17:27,540
+تانية اللي هي ال topology تبعت ال network نفسها
+
+196
+00:17:27,540 --> 00:17:31,680
+يعني مين من ال nodes مرتبطة بمين من ال nodes يعني
+
+197
+00:17:31,680 --> 00:17:37,320
+احنا هنا قررنا مسبقا ان هذا ال network هيك شكلها
+
+198
+00:17:37,320 --> 00:17:43,320
+هيك علاقة ال nodes ببعض هذه توزنت جميع هذه توزنت
+
+199
+00:17:43,320 --> 00:17:43,640
+جميع
+
+200
+00:17:46,850 --> 00:17:51,110
+تاخد من الجميع اللي جابلها طب افترض انا بدي اعمل
+
+201
+00:17:51,110 --> 00:17:56,730
+.. تفترض بدنا نشوف لربما هولاك .. ايش عن ال
+
+202
+00:17:56,730 --> 00:17:59,470
+topology؟ انا استخدمت المصطلح هذا اكتر من مرة قبلك
+
+203
+00:17:59,470 --> 00:18:03,310
+.. بس واضح ايش معناته؟ topology يعني اللي هو ال
+
+204
+00:18:03,310 --> 00:18:08,210
+links ما بين ال nodes الارتباطات ما بين ال nodes
+
+205
+00:18:08,210 --> 00:18:12,810
+سبعة ال network افترض ان انا بدي اعمل .. افترض ان
+
+206
+00:18:12,810 --> 00:18:18,030
+انا بدي اجرب لربما يكون في ..توزيع أخرى أفضل ربما
+
+207
+00:18:18,030 --> 00:18:22,990
+هذه مش ضرورة تاخد من الأربعة كلها ممكن نكتفي
+
+208
+00:18:22,990 --> 00:18:28,790
+بتلاتة فقط هذا الأمر برضه ممكن نخضعه لل genetic أو
+
+209
+00:18:28,790 --> 00:18:36,470
+لل evolutionary computation بمعنى أنه لو جينا قلنا
+
+210
+00:18:36,470 --> 00:18:45,990
+هذا ال network دمثلها العلاقات أو topologyتمثل
+
+211
+00:18:45,990 --> 00:18:50,070
+بالجدول هذا بمعنى إيش أنه وين ما فيه link نحط واحد
+
+212
+00:18:50,070 --> 00:18:57,010
+مابين
+
+213
+00:18:57,010 --> 00:19:01,630
+واحد واربعة فيه link صح؟ مابين اتنين واربعة مافيش
+
+214
+00:19:01,630 --> 00:19:07,870
+link صح؟ اي واحد الاربعة اي واحد الاربعة فيه link
+
+215
+00:19:07,870 --> 00:19:11,390
+from two
+
+216
+00:19:15,450 --> 00:19:18,570
+من واحد الى أربعة فيه link بس من اتنين الى أربعة
+
+217
+00:19:18,570 --> 00:19:22,450
+مافيش link صح؟
+
+218
+00:19:22,450 --> 00:19:34,410
+من اتنين الى أربعة مافيش link هذا الشكل انا
+
+219
+00:19:34,410 --> 00:19:37,950
+بعبر
+
+220
+00:19:37,950 --> 00:19:43,950
+عن علقة أو links ما بين ال nodes لأن كروموزورد كيف
+
+221
+00:19:43,950 --> 00:19:44,710
+حيكون شكله
+
+222
+00:19:51,530 --> 00:19:55,930
+هأخذ المصفوفة كلها زي ما هي و أمر عنها بـ
+
+223
+00:19:55,930 --> 00:20:03,010
+chromosome من واحد إلى من
+
+224
+00:20:03,010 --> 00:20:12,970
+واحد إلى ذات النص من
+
+225
+00:20:12,970 --> 00:20:18,610
+واحد من اتنين إلى ذات النص صح؟
+
+226
+00:20:21,090 --> 00:20:26,950
+بعدين من ثلاثة إلى بقى النص المصبوط
+
+227
+00:20:26,950 --> 00:20:30,590
+قليل
+
+228
+00:20:30,590 --> 00:20:41,570
+من أربعة إلى بقى النص قليل من خمسة إلى بقى النص
+
+229
+00:20:41,570 --> 00:20:45,630
+قليل
+
+230
+00:20:45,630 --> 00:20:53,290
+من ستة إلى بقى النص كل ستة bits يمثلونعلاقة node
+
+231
+00:20:53,290 --> 00:20:58,610
+بالاخريات تمام
+
+232
+00:20:58,610 --> 00:21:04,030
+احنا لقنا ان الهدف تبعنا .. ايش الهدف تبعنا في هذا
+
+233
+00:21:04,030 --> 00:21:09,450
+ال problem الهدف تبعنا هو الوصول الى ال network
+
+234
+00:21:09,450 --> 00:21:17,610
+اللى ال topology بتبعتها بتحقق الهدف
+
+235
+00:21:25,250 --> 00:21:30,690
+نفس العملية نفس القالية مثلا في عندي data في عندي
+
+236
+00:21:30,690 --> 00:21:35,510
+data و في عندي chromosomes كل chromosome يمثل برضه
+
+237
+00:21:35,510 --> 00:21:38,070
+network أخرى بس هنا ال network مختلفة مش في
+
+238
+00:21:38,070 --> 00:21:43,930
+الأوزان مختلفة في ال topology صح نفحص كل network
+
+239
+00:21:43,930 --> 00:21:49,490
+بناء على ال data و نشوف ايش ال total error او ال
+
+240
+00:21:49,490 --> 00:21:52,750
+average error او ال sum of square differences مثلا
+
+241
+00:21:53,190 --> 00:21:58,370
+نفس الشيء في التاني السابق وبنقيم ال chromosomes
+
+242
+00:21:58,370 --> 00:22:04,050
+على هذا الأساس okay
+
+243
+00:22:04,050 --> 00:22:08,230
+وبناء
+
+244
+00:22:08,230 --> 00:22:15,070
+على التقييم بنختار منهم لل crossover وبنختار كمان
+
+245
+00:22:15,070 --> 00:22:20,550
+للمutation فهذه
+
+246
+00:22:20,550 --> 00:22:25,130
+هي باختصار شديدالقليل اللى على أساسها بيقوم الدمج
+
+247
+00:22:25,130 --> 00:22:34,430
+ما بين ما بين الاش ال neural networks و ما بين ال
+
+248
+00:22:34,430 --> 00:22:38,450
+evolutionary algorithm أو ال genetic algorithm
+
+249
+00:23:14,970 --> 00:23:39,730
+نرجع مرة تانية ننخذ
+
+250
+00:23:39,730 --> 00:23:45,680
+كلام سريعمفتوطين الأساسيات اللى احنا ممكن نحتاج
+
+251
+00:23:45,680 --> 00:23:52,040
+الى ال evolutionary computation فيهم مع النورا
+
+252
+00:23:52,040 --> 00:23:59,180
+نتويرد انه is اللى هو عملية ال training ال back
+
+253
+00:23:59,180 --> 00:24:02,720
+propagation learning algorithm cannot guarantee an
+
+254
+00:24:02,720 --> 00:24:06,420
+optimal solution فاحنا ال back propagation
+
+255
+00:24:06,420 --> 00:24:10,520
+learning اللى هي علييتنا الأساسية في تعديل الأوزان
+
+256
+00:24:11,180 --> 00:24:15,380
+مش دايما تعطيني solution فانا ممكن ا .. an optimal
+
+257
+00:24:15,380 --> 00:24:19,600
+solution فانا ممكن ابحث عن ال optimal solution
+
+258
+00:24:19,600 --> 00:24:22,840
+باسلوب اخر اللي هو ال genetic او ال evolutionary
+
+259
+00:24:22,840 --> 00:24:27,520
+اللي هو اصلا ميزته
+
+260
+00:24:27,520 --> 00:24:30,660
+الأساسية هي ال optimization ال evolutionary او ال
+
+261
+00:24:30,660 --> 00:24:33,460
+genetic algorithm ميزتها الأساسية انه تعطيني
+
+262
+00:24:33,460 --> 00:24:38,060
+optimization بمعنى افضل ما يمكن الوصول اليه فال ..
+
+263
+00:24:39,250 --> 00:24:42,330
+النورة ال network is often unable to find a
+
+264
+00:24:42,330 --> 00:24:44,910
+desirable solution to a problem at hand هذه أول
+
+265
+00:24:44,910 --> 00:24:50,370
+نقطة الأوزان النقطة التانية اللي احنا ممكن نحتاج
+
+266
+00:24:50,370 --> 00:24:53,610
+لنورة ال network فيها اللي هي ال optimal topology
+
+267
+00:24:53,610 --> 00:25:01,030
+اللي اصل إلى أفضل أو أنسب topology لل network اللي
+
+268
+00:25:01,030 --> 00:25:06,610
+تعطيني أفضل network فالان
+
+269
+00:25:08,250 --> 00:25:12,650
+بعد ما احنا اول خطوة بنسويها اللي هي انه to
+
+270
+00:25:12,650 --> 00:25:17,570
+represent ال problem على شكل chromosomes ال
+
+271
+00:25:17,570 --> 00:25:22,170
+problem الان هل هي أوزان ولا topology في الحالتين
+
+272
+00:25:22,170 --> 00:25:25,530
+بعبر عنها على شكل ايش؟ chromosome هنا ال
+
+273
+00:25:25,530 --> 00:25:29,110
+chromosome بيحتوي اذا هي أوزان بيحتوي على أوزان ال
+
+274
+00:25:29,110 --> 00:25:34,110
+noise اذا هي ال problem تبعتي اللي انا بدي .. اللي
+
+275
+00:25:34,110 --> 00:25:37,620
+هي مثلة ال topologyال .. ال .. ال genes تبع ال
+
+276
+00:25:37,620 --> 00:25:41,200
+chromosome بتكون ones و zeros اشارة الى العلاقات
+
+277
+00:25:41,200 --> 00:25:45,420
+ما بين ال noise okay فال second step دلوقت is to
+
+278
+00:25:45,420 --> 00:25:53,420
+evaluate ال fitness تبع evaluate ال fitness تبع ال
+
+279
+00:25:53,420 --> 00:26:00,100
+chromosomes okay هذا الكلام بناء على ال training
+
+280
+00:26:00,100 --> 00:26:01,700
+set اللي احنا
+
+281
+00:26:06,080 --> 00:26:11,360
+أو ال data الموجودة عندنا فممكن نحسب ال errors
+
+282
+00:26:11,360 --> 00:26:19,940
+طبعا كل chromosome مع أو against يعني كل ال data و
+
+283
+00:26:19,940 --> 00:26:22,520
+نحسب ال sum of square errors يعني ال errors هذه
+
+284
+00:26:22,520 --> 00:26:25,100
+اللي بتتجمع ال error and هذا و error and هذا و
+
+285
+00:26:25,100 --> 00:26:28,080
+error and هذا كلهم نحسب ليهش ال sum of square
+
+286
+00:26:28,080 --> 00:26:33,870
+errorsهذا ال sum من ال zero بيبقى أحسن ولا بيبقى
+
+287
+00:26:33,870 --> 00:26:39,030
+أسوأ بيبقى أفضل لإن أنا بدي ال errors تقريبا تبقى
+
+288
+00:26:39,030 --> 00:26:43,290
+صغر تمام the smaller the sum the fitter the
+
+289
+00:26:43,290 --> 00:26:47,610
+chromosome كل مكان أصغر كل مكان موفيت الان ال
+
+290
+00:26:47,610 --> 00:26:51,450
+genetic algorithm attempts to find مجموعة ال
+
+291
+00:26:51,450 --> 00:26:55,810
+weights اللي فعلا minimizes أو توصلني إلى هذا
+
+292
+00:26:55,810 --> 00:27:03,210
+الرقم الصغيرأيش بعد ما عمل ال fitness قلنا ثالث
+
+293
+00:27:03,210 --> 00:27:08,950
+خطوة ثالث
+
+294
+00:27:08,950 --> 00:27:14,830
+خطوة نعتبرهم واحدة اللي هي applying genetic
+
+295
+00:27:14,830 --> 00:27:18,250
+operators نسميهم genetic operators هدولة ال
+
+296
+00:27:18,250 --> 00:27:22,090
+crossover زائد
+
+297
+00:27:22,090 --> 00:27:27,590
+limitation هدولة
+
+298
+00:27:27,590 --> 00:27:28,310
+اللي هو ال genetic
+
+299
+00:27:38,750 --> 00:27:42,350
+Crossover operator takes two parents chromosomes
+
+300
+00:27:42,350 --> 00:27:45,310
+and creates a single child with genetic material
+
+301
+00:27:45,310 --> 00:27:49,730
+from the parents قلية الـ crossover واضحة لنا اللي
+
+302
+00:27:49,730 --> 00:27:54,150
+هي أولا رولية عشان نختار مين المرشحين وبعدها ال
+
+303
+00:27:54,150 --> 00:27:59,160
+probability عشان نختار زوج زوج صحو بينما ال
+
+304
+00:27:59,160 --> 00:28:02,200
+mutation .. ال mutation على طول على ال output اللي
+
+305
+00:28:02,200 --> 00:28:08,500
+بيطلع من ال crossover ب .. ألف علشان أحدد مين اللي
+
+306
+00:28:08,500 --> 00:28:13,200
+أ .. أخض عليه او أوقع عليه اللي هو ال .. اللي هو
+
+307
+00:28:13,200 --> 00:28:20,240
+ال .. ال mutation okay select a gene لأن كلمة gene
+
+308
+00:28:20,240 --> 00:28:26,960
+هنا بدها تبقى واضحة لي مسبقا هل أنا بحكي عنهbit
+
+309
+00:28:26,960 --> 00:28:32,700
+واحدة ولا بحكي عن ال vector تبع node معينة يعني ال
+
+310
+00:28:32,700 --> 00:28:35,440
+node تلاتة كل الأوزان تبعونها يعني هذه أنظر إيه
+
+311
+00:28:35,440 --> 00:28:39,600
+معناه ال gene ولا الوزن الواحد لوحده هو ال gene
+
+312
+00:28:39,600 --> 00:28:42,580
+هذا الكلام لازم يبقى محدد وإذا جالك سؤال يبقى
+
+313
+00:28:42,580 --> 00:28:51,940
+محددك بالظبط انت حاكي عن .. حاكي
+
+314
+00:28:51,940 --> 00:28:55,620
+عن node ولا عن وزن واحد
+
+315
+00:29:02,020 --> 00:29:06,900
+Okay كمان؟ فالصورة ان هنا ال cross over ما بين
+
+316
+00:29:06,900 --> 00:29:13,000
+هدول الاتنين هدول دقان two different sets of
+
+317
+00:29:13,000 --> 00:29:17,180
+weights يعني مجموعات او مجموعاتين أو زاد ل network
+
+318
+00:29:17,180 --> 00:29:21,040
+نفس ال topology ايش اللي بيصلي هنا؟ ماخد هذا ال
+
+319
+00:29:21,040 --> 00:29:27,130
+gene من هذا ال parent و ماخد ايش؟الذين بعدوا من
+
+320
+00:29:27,130 --> 00:29:33,530
+هذا صح والذين بعدوا من هذا وناخد الأخير من هنا
+
+321
+00:29:33,530 --> 00:29:40,510
+يبقى عاش عامل عامل split على صح
+
+322
+00:29:40,510 --> 00:29:47,090
+هذا الشق ناخده لحال و هذول لحال هذول اتنين نزلهم
+
+323
+00:29:47,090 --> 00:29:53,190
+هذول اتنين نزلهم من الأول و هذول اتنين نزلهم من
+
+324
+00:29:53,190 --> 00:29:58,770
+التانيتذكروا ان ال cross over ممكن تبقى على one
+
+325
+00:29:58,770 --> 00:30:03,070
+single splitting point او cross over point او على
+
+326
+00:30:03,070 --> 00:30:06,570
+two حسب ما انت بتختار لنفسك اذا انت اللي بتصمم
+
+327
+00:30:06,570 --> 00:30:09,910
+لهذا او حسب السؤال اللي بيقولك اذا انت في الامتحان
+
+328
+00:30:09,910 --> 00:30:15,310
+okay limitation هنا عملها على اساس هيش single
+
+329
+00:30:15,310 --> 00:30:21,450
+weight ولا single node يعني ضلللي الضلمين هذول مع
+
+330
+00:30:21,450 --> 00:30:23,890
+بعض ليش بفهم انه بحكي عن ال node هذه
+
+331
+00:30:43,370 --> 00:30:48,430
+عشوائيًا غيرهم إلى سالب
+
+332
+00:30:48,430 --> 00:30:55,100
+0.1 و 0.2ماخد ال node كلها على اساس انها جين واحد
+
+333
+00:30:55,100 --> 00:31:01,640
+تمام
+
+334
+00:31:01,640 --> 00:31:04,700
+خلاص هذا بالنسبة لو كان ايش اوزان تعديل اوزان
+
+335
+00:31:04,700 --> 00:31:10,000
+بالنسبة لو تعديل ال topology تعديل ال topology او
+
+336
+00:31:10,000 --> 00:31:15,580
+اختيار ال topology الأنسب فنفس القالية انما اللي
+
+337
+00:31:15,580 --> 00:31:19,510
+بختلف اللي هو the basic idea behind itبغض الـ
+
+338
+00:31:19,510 --> 00:31:22,890
+suitable network architecture انه تconduct a
+
+339
+00:31:22,890 --> 00:31:26,930
+genetic search في اللي هو different architecture
+
+340
+00:31:26,930 --> 00:31:31,390
+we must first choose a method لتعبير عن ال
+
+341
+00:31:31,390 --> 00:31:39,490
+chromosome ال chromosome الان بدوش يحتوي على أوزان
+
+342
+00:31:39,490 --> 00:31:44,530
+بده يحتوي على علاقات فزي ما قلنا ال zero لما يكون
+
+343
+00:31:44,530 --> 00:31:47,510
+مافيش link من node إلى node و ال one لما يكون فيه
+
+344
+00:31:47,510 --> 00:31:52,960
+linkهدا هو في
+
+345
+00:31:52,960 --> 00:32:00,000
+أسئلة احنا الآن عمليا هذا هو كل ما .. ماهو هناك
+
+346
+00:32:00,000 --> 00:32:08,180
+بالنسبة لل إيش لل hybrid ايش قلنا neuro او ما بين
+
+347
+00:32:08,180 --> 00:32:11,580
+ال genetic و ما بين ال neural network و الشقة
+
+348
+00:32:11,580 --> 00:32:14,020
+التانية بتخيليها المحاضرة اللي جاي اللي هو ما بين
+
+349
+00:32:14,020 --> 00:32:17,540
+الناس الفظي و ال genetic الفظي و ال genetic الشقة
+
+350
+00:32:17,540 --> 00:32:25,830
+التانيةطبعا فظيه evolutionally في اي سؤال؟ طيب
+
+351
+00:32:25,830 --> 00:32:26,110
+ماشي
+
diff --git a/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/vx9l8pHNUU8_postprocess.srt b/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/vx9l8pHNUU8_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..75947238007c4a6f24a1d621355d1d483379e514
--- /dev/null
+++ b/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/vx9l8pHNUU8_postprocess.srt
@@ -0,0 +1,1608 @@
+1
+00:00:20,720 --> 00:00:25,920
+بسم الله الرحمن الرحيم محاضرة اليوم تكملة لموضوع
+
+2
+00:00:25,920 --> 00:00:34,260
+ال informed search ماشي احنا في chapter أربعة
+
+3
+00:00:34,260 --> 00:00:39,800
+بدينا في موضوع ال informed search كان ال
+
+4
+00:00:39,800 --> 00:00:43,980
+algorithmات اللي شفناها قبل هيكة اللي هم ال a star
+
+5
+00:00:43,980 --> 00:00:50,680
+algorithm كانت بتحكي عن اللي هو البحث عن ال goalأو
+
+6
+00:00:50,680 --> 00:00:54,320
+الهدف منها كان البحث عن ال goal و بأقصر مسار بأقصر
+
+7
+00:00:54,320 --> 00:01:01,560
+مسار في مسائل يكون الهدف هو ال goal و المسار مش
+
+8
+00:01:01,560 --> 00:01:06,640
+مهم المسار مش مهم ففي هذه الحلقة بسميها ال search
+
+9
+00:01:06,640 --> 00:01:14,140
+بسميه local search في ال chapter هذا ال section
+
+10
+00:01:14,140 --> 00:01:16,560
+الأولية اللي من أربعة اللي هو أربعة واحد local
+
+11
+00:01:16,560 --> 00:01:19,550
+search algorithmalgorithms and optimization
+
+12
+00:01:19,550 --> 00:01:23,210
+problems فاحنا الآن المحاضرة دي بنطلع على هذا
+
+13
+00:01:23,210 --> 00:01:26,230
+النوع من ال search algorithms اللي هو ال local
+
+14
+00:01:26,230 --> 00:01:36,870
+search algorithms وبالتحديد
+
+15
+00:01:36,870 --> 00:01:41,850
+فيها ان اللي هم التلاتة دولة hill climbing
+
+16
+00:01:46,750 --> 00:01:50,890
+و Simulated Annealing
+
+17
+00:01:50,890 --> 00:02:03,010
+و Local Beam Search الـ
+
+18
+00:02:03,010 --> 00:02:08,270
+Genetic Algorithm جاي هنا تحت هذا الفئة لكن احنا
+
+19
+00:02:08,270 --> 00:02:14,320
+هنشوفها قدام بعد هناموجودة و مقتضب جدا نحكي عنها
+
+20
+00:02:14,320 --> 00:02:18,740
+احنا هنشوفها قدام بالتفصيل اكتر من ال textbook
+
+21
+00:02:18,740 --> 00:02:22,940
+التاني تمام من الكتاب التاني باقي ال sections اللي
+
+22
+00:02:22,940 --> 00:02:28,380
+في chapter 4 مش هنطلع عليها بيكفينا هذا النوع من
+
+23
+00:02:28,380 --> 00:02:32,240
+ال search الان ال local search في chapter 5 بنشوف
+
+24
+00:02:32,240 --> 00:02:35,460
+ال adversarial search اللي هو ال search اللي بيكون
+
+25
+00:02:35,460 --> 00:02:40,340
+في games و ال games هذه فيها تنافس ما بين برافين
+
+26
+00:02:41,220 --> 00:02:46,520
+Okay فالان احنا في ال local search algorithms نشوف
+
+27
+00:02:46,520 --> 00:02:51,080
+اول محلل هو ال hill climbing search ال hill
+
+28
+00:02:51,080 --> 00:02:54,660
+climbing search من اسمها او خلينا جبه نشوف ال
+
+29
+00:02:54,660 --> 00:02:59,000
+algorithm نطلع على الرسم هادي بتوضح قلية عمل ال ..
+
+30
+00:02:59,000 --> 00:03:03,400
+او بناخد فكرة عن .. فكرة ال algorithm انه احنا ال
+
+31
+00:03:03,400 --> 00:03:09,440
+.. ال .. ال node او ال algorithm بتدفع على node و
+
+32
+00:03:09,440 --> 00:03:14,800
+بتشوف ايشchildren بتفرع منها بتتطلع على ال
+
+33
+00:03:14,800 --> 00:03:21,700
+children هدولة و تاخد أفضل واحدة طبعا الان ممكن
+
+34
+00:03:21,700 --> 00:03:29,460
+تصل في وجهة من الأوجات يعني دائما هذه الزمن
+
+35
+00:03:29,460 --> 00:03:36,760
+هيك طبعا stay space لما تبدأ على node واحدة يفترض
+
+36
+00:03:36,760 --> 00:03:40,720
+انها تاخد nodeلو تنتقل على ال node التاني يفترض أن
+
+37
+00:03:40,720 --> 00:03:44,060
+التاني أفضل منها في التقييم يعني إذا كانت هذه
+
+38
+00:03:44,060 --> 00:03:48,240
+التقييم تبعها تلاتة و هدولة ال children في منهم
+
+39
+00:03:48,240 --> 00:03:50,700
+الأتنين و في منهم الأربعة و في منهم الخمسة و في
+
+40
+00:03:50,700 --> 00:03:53,840
+منهم الستة و في منهم الستة و في منهم السبعة هي
+
+41
+00:03:53,840 --> 00:03:57,440
+هتاخد الأفضل ما بين ال children فانتقالها من ال
+
+42
+00:03:57,440 --> 00:04:03,900
+node إلى ال node يفترض بيعطيها سؤوة في جودة ال
+
+43
+00:04:03,900 --> 00:04:08,530
+node تنتقل من ال node الأسوأ إلى الأحسنفهنا ال
+
+44
+00:04:08,530 --> 00:04:11,470
+objective function اللي نفسط بيها انه ال objective
+
+45
+00:04:11,470 --> 00:04:13,810
+function هي ال function بتاعة التقييم لل node
+
+46
+00:04:13,810 --> 00:04:18,130
+فيفترض انه احنا كل ما تقدمت عملية ال search و فحصت
+
+47
+00:04:18,130 --> 00:04:22,830
+المزيد من ال nodes كل node تبقى افضل من اللي
+
+48
+00:04:22,830 --> 00:04:29,350
+جابلها يبقى احنا ياشهر بنصعد صعودا في جودة ال
+
+49
+00:04:29,350 --> 00:04:35,790
+nodes الهدف تبعنا انه اصل ال node الأفضل ال node
+
+50
+00:04:35,790 --> 00:04:39,120
+الأفضل من ناحية ايشمن ناحية ال objective من ناحية
+
+51
+00:04:39,120 --> 00:04:41,920
+التقييم يعني إيش من ناحية التقييم من ناحية قربها
+
+52
+00:04:41,920 --> 00:04:45,800
+من الهدف صح ولا لأنه إحنا التقييم عندنا المقصود
+
+53
+00:04:45,800 --> 00:04:50,880
+بيه إيش جداش هذه ال note بتقربني إلى الهدف فكل ما
+
+54
+00:04:50,880 --> 00:04:54,480
+كانت تقييم عالي .. عالي أنا مقصود مش بالقيمة عالية
+
+55
+00:04:54,480 --> 00:04:57,560
+يعني من ناحية الجوة .. أجوة ممكن يكون اللي أقل هو
+
+56
+00:04:57,560 --> 00:05:02,380
+اللي أفضل تمام فجودة ال note جودة ال note يعني
+
+57
+00:05:02,380 --> 00:05:07,640
+جداش بتقربني إلى الهدففانتقال ال algorithm من node
+
+58
+00:05:07,640 --> 00:05:10,360
+إلى اللي بعدها إلى اللي بعدها بغض النظر هي تتقل في
+
+59
+00:05:10,360 --> 00:05:14,460
+أي اتجاه المهم هي تنتقل من node إلى node انتقالها
+
+60
+00:05:14,460 --> 00:05:18,020
+من node إلى node يفترض أنه يعطيني جودة في التقييم
+
+61
+00:05:18,020 --> 00:05:21,940
+ال node اللي بنتقل إليها أفضل من السابق واضح هذا
+
+62
+00:05:21,940 --> 00:05:25,920
+الكلام لكن هذا الكلام مش دائما مضمون يعني ممكن تصل
+
+63
+00:05:25,920 --> 00:05:33,800
+ال algorithm إلى node ويبقى كل ال options المتاحة
+
+64
+00:05:33,800 --> 00:05:35,180
+إلها المتفرعة منها
+
+65
+00:05:38,240 --> 00:05:42,340
+زيها بالظبط يعني هي بتبقى خمسة و كل ال notes
+
+66
+00:05:42,340 --> 00:05:48,600
+المتفارعة منها تقيمهم خمسة أصبح ايش؟ أصبح هي الآن
+
+67
+00:05:48,600 --> 00:05:54,020
+في موضوع محلك سر محلك سر ايش يعني؟ يعني لو أخدت
+
+68
+00:05:54,020 --> 00:05:58,820
+هذا ولا هذا ولا هذا ولا هذا ولا هذا مش هتفرق طب
+
+69
+00:05:58,820 --> 00:06:03,590
+إيش السبب في الحالة هذه؟في الحالة هذه ال algorithm
+
+70
+00:06:03,590 --> 00:06:08,090
+نفسها تجف by default بتجف لأنه الاستمراري تبعتها
+
+71
+00:06:08,090 --> 00:06:12,590
+ان طالما انه في مجال لتحسين للانتقال الى state
+
+72
+00:06:12,590 --> 00:06:18,770
+افضل بنستمر مافيش مجال يبقى ليش بنجف فهذا الآن
+
+73
+00:06:18,770 --> 00:06:25,730
+ومثله زي و برضه هذا الكلام ومثله هذا الكلام لأ
+
+74
+00:06:25,730 --> 00:06:30,210
+ناسف هذا الكلامهذا الكلام معناته انت لو وقفت على
+
+75
+00:06:30,210 --> 00:06:34,430
+نقطة اللي حواليك او على نوت اللي حواليها او اللي
+
+76
+00:06:34,430 --> 00:06:41,590
+متفرع منها اما مثلها او
+
+77
+00:06:41,590 --> 00:06:47,090
+اسوأ لسه منها صح ولا لأ اذا انا واقف هنا اللي
+
+78
+00:06:47,090 --> 00:06:51,270
+جابلي اسوأ مني لان انا جاي منها و اللي بعدي اسوأ
+
+79
+00:06:51,270 --> 00:06:53,610
+يبقى فات فاهمة اللي هاد الحالة و فاهمة اللي هاد
+
+80
+00:06:53,610 --> 00:06:55,110
+الحالة و فاهمة اللي هاد الحالة اللي انا عايشه
+
+81
+00:06:55,110 --> 00:06:59,010
+يفترض ال algorithm تجفهدول الحالات بيسميهم local
+
+82
+00:06:59,010 --> 00:07:05,510
+minima أو local maxima عسب أنك بتبحث عن الأقل ولا
+
+83
+00:07:05,510 --> 00:07:09,410
+بتبحث عن الأعلى local أما ال global اللي هو ال
+
+84
+00:07:09,410 --> 00:07:13,450
+goal تبعك اللي هو الأفضل على الإطلاق ناشي اللي هو
+
+85
+00:07:13,450 --> 00:07:16,970
+أعلى واحد هذا الكلام انت ممكن ماتصلوش ال algorithm
+
+86
+00:07:16,970 --> 00:07:23,990
+ممكن تجف هنا تجف هنا و ت .. و ت .. و ت .. و ت .. و
+
+87
+00:07:23,990 --> 00:07:24,030
+ت .. و ت .. و ت .. و ت .. و ت .. و ت .. و ت .. و ت
+
+88
+00:07:24,030 --> 00:07:25,370
+.. و ت .. و ت .. و ت .. و ت .. و ت .. و ت .. و ت
+
+89
+00:07:25,370 --> 00:07:25,590
+.. و ت .. و ت .. و ت .. و ت .. و ت .. و ت .. و ت
+
+90
+00:07:25,590 --> 00:07:25,670
+.. و ت .. و ت .. و ت .. و ت .. و ت .. و ت .. و ت
+
+91
+00:07:25,670 --> 00:07:31,670
+.. و ت .. و تلماذا تضرب stop؟ لأنه مافي خيار
+
+92
+00:07:31,670 --> 00:07:38,390
+أفضل اللي جابلها أسوأ و اللي قدام كلهم مساوين
+
+93
+00:07:38,390 --> 00:07:45,170
+الجماعة بتجدد و هنا كذلك و هنا كذلك إذا هي هنا
+
+94
+00:07:45,170 --> 00:07:52,490
+تستمر في الصعود إذا هي هنا تستمر في الصعود فهذا
+
+95
+00:07:52,490 --> 00:07:57,530
+الكلام الآنالوضع هذا نسميه shoulder و الوضع هذا
+
+96
+00:07:57,530 --> 00:08:01,570
+نسميه plateau ايش الفرق ما بين ال shoulder و ال
+
+97
+00:08:01,570 --> 00:08:07,950
+plateau ان ال plateau من جبله و من بعده أسوأ ال
+
+98
+00:08:07,950 --> 00:08:11,630
+shoulder من جبله أسوأ لكن من بعده ممكن فيه أمل
+
+99
+00:08:11,630 --> 00:08:19,110
+نصعد ل maximum فانا في ال plateau او ال flat local
+
+100
+00:08:19,110 --> 00:08:23,470
+minimum لو استمرت
+
+101
+00:08:23,990 --> 00:08:26,910
+مافيش فايد اطلاقا يعني لو قلت انا مثلا ال
+
+102
+00:08:26,910 --> 00:08:31,230
+algorithm خليني اسمح لها انها تمشي ماشي تاخد هذا
+
+103
+00:08:31,230 --> 00:08:34,710
+هذه خمسة و ال node اللي بعدها خمسة ماشي الحالة و
+
+104
+00:08:34,710 --> 00:08:38,770
+ربما الخمسة هي اللي بتفرع منها كمان خمسات تمام
+
+105
+00:08:38,770 --> 00:08:43,010
+تستمر تسمح لها تستمر في الانتقال على الضغط من انه
+
+106
+00:08:43,010 --> 00:08:48,430
+مافيش تحسن معناه دالك احنا بنتوجه على الخط الأفقي
+
+107
+00:08:48,430 --> 00:08:49,410
+صح؟
+
+108
+00:08:51,440 --> 00:08:59,580
+هذا الخط يمثل ال notes في مقابل جودة ال notes انا
+
+109
+00:08:59,580 --> 00:09:04,300
+جاهز باستمر و هنا الجودة بتطلع معايا بس هنا انا
+
+110
+00:09:04,300 --> 00:09:08,940
+باستمر لكن الجودة ثابتة مظبوط و هنا كذلك انا
+
+111
+00:09:08,940 --> 00:09:14,810
+بعبرلك على هذا الكلام من فضل انه ال noteفحصة node
+
+112
+00:09:14,810 --> 00:09:17,290
+و ال node ده كانت خمسة و ال children اللي متفرعة
+
+113
+00:09:17,290 --> 00:09:20,430
+منها أضابط خمسة و اللي متفرعة منها خمسة خمسة و دلت
+
+114
+00:09:20,430 --> 00:09:24,430
+تنتقل من خمسة إلى خمسة على الرقم لإنه مافيه فرق
+
+115
+00:09:24,430 --> 00:09:32,110
+لكن جدام ربنا تحت تحت تحت بعد كده level أجت واحدة
+
+116
+00:09:32,110 --> 00:09:37,110
+خمسة و اتفرع منها إشي أفضل من الخمسة كل سبعة أو
+
+117
+00:09:37,110 --> 00:09:42,670
+عشرة وجهتها بتكون إيش طلعت من ال shoulderو قاعدة
+
+118
+00:09:42,670 --> 00:09:48,790
+بتاعش بتزيد في ال efficiency هذا مثال توضيحي فقط
+
+119
+00:09:48,790 --> 00:09:52,510
+لتعني ال morphine algorithm هذا algorithm بس لو
+
+120
+00:09:52,510 --> 00:09:57,830
+تطلع بس لو نزلت تتوقع تتوقع احنا ببساطة شديدة ال
+
+121
+00:09:57,830 --> 00:10:01,470
+hill climbing algorithm زي ما قلت انا انها تستمر
+
+122
+00:10:01,470 --> 00:10:07,290
+لحد اما تلاقي ال goal او يبقى مافيش داعي للاستمرار
+
+123
+00:10:07,290 --> 00:10:11,830
+ايش يعني مافيش داعي للاستمرار يعني اناواجف على
+
+124
+00:10:11,830 --> 00:10:17,570
+node ال node هذه قيمتها كذا وكل اللي متفرع منها
+
+125
+00:10:17,570 --> 00:10:22,330
+زيها أو أسوأ يبقى ليش .. يبقى كيف ده انتقل قالية
+
+126
+00:10:22,330 --> 00:10:26,230
+حركتها الوحيدة انه انتقل الى الأفضل ال hill
+
+127
+00:10:26,230 --> 00:10:30,730
+climbing اسم ال hill climbing يعني تساقط اه فانا
+
+128
+00:10:30,730 --> 00:10:35,550
+كنت على مستمرةبطلع حوليا وين في حجر اطلع عليه انا
+
+129
+00:10:35,550 --> 00:10:41,450
+بتسلق في تلة او في جبل وين في صخرة او حجر اطلع منه
+
+130
+00:10:41,450 --> 00:10:47,230
+لأعلى بخطي مالاقيتش لاجيت كل اللي حوليا نفس
+
+131
+00:10:47,230 --> 00:10:51,910
+المستوى او من هنا نزول و من هنا نزول يبقى بوقف هذه
+
+132
+00:10:51,910 --> 00:10:55,170
+قالية او ال strategy تبع حركة ال hill climbing
+
+133
+00:10:55,170 --> 00:10:55,770
+algorithm
+
+134
+00:10:58,700 --> 00:11:02,760
+بنقول أن قالية هذه فيها مشكلة لأنه ممكن و هي تصعد
+
+135
+00:11:02,760 --> 00:11:07,440
+تصعد تصعد تنتقل من node إلى node و الانتقال هذا
+
+136
+00:11:07,440 --> 00:11:11,480
+يبقى فيه صعود أو تحسن في جودة ال nodes إلى أن تصل
+
+137
+00:11:11,480 --> 00:11:15,620
+إلى node ال node هذه بتدخلها على خيارات الخيارات
+
+138
+00:11:15,620 --> 00:11:21,620
+كلها أما أسوأ أو مساوية يبقى تبقى اوتوماتيكية لل
+
+139
+00:11:21,620 --> 00:11:26,140
+algorithm هتجف هتجف بدون ما تكون لاجت ال goal وهذا
+
+140
+00:11:26,140 --> 00:11:33,720
+إيش معناته مشبلغة الخصائص مش إيش إذا وقفت و من غير
+
+141
+00:11:33,720 --> 00:11:39,360
+ما تلاقي ال goal مش complete بالظبط مش complete و
+
+142
+00:11:39,360 --> 00:11:43,700
+عدم ال completeness هي رجايم إما إما تجه تهلك في
+
+143
+00:11:43,700 --> 00:11:48,020
+shoulder أو تهلك في plateau أو تهلك في maximum
+
+144
+00:11:48,020 --> 00:11:52,020
+ماتبجعش هي ال global ماتبجعش هي ال global
+
+145
+00:11:56,190 --> 00:12:00,770
+هذا ببساطة اللي هو قليل عمل في ال climbing من
+
+146
+00:12:00,770 --> 00:12:08,950
+ناحية algorithm ك algorithm خطواتها طب
+
+147
+00:12:08,950 --> 00:12:12,970
+احنا لما خدنا ال best strategy لما كانت تصل لنقطة
+
+148
+00:12:12,970 --> 00:12:18,910
+بيكون عندها تفرق تبحر في عندها ال J of H متساوية
+
+149
+00:12:18,910 --> 00:12:24,520
+كانت تختار عملي جدا هدفها في ال A starطب هنا اسمها
+
+150
+00:12:24,520 --> 00:12:30,240
+local، local يعني انطق النظر تبحق قصير، تتطلع بس
+
+151
+00:12:30,240 --> 00:12:34,440
+على، عشان، على الدائرة المباشرة المحيطة يبقى، يعني
+
+152
+00:12:34,440 --> 00:12:36,540
+ال node اللي أنا واقف عليها و ال children اللي
+
+153
+00:12:36,540 --> 00:12:42,080
+بتفرها مني، تمام؟ ما بتقدر تشوف أبعد من هيك، اللي
+
+154
+00:12:42,080 --> 00:12:47,440
+تستكشف إن والله ورا ال plateau هذا، ورا ال plateau
+
+155
+00:12:47,440 --> 00:12:51,380
+هذا، ممكن يكون في node أفضل، فانا أستمر
+
+156
+00:12:55,570 --> 00:13:01,450
+القليل من العمل هو أننا نقف على ال node لل current
+
+157
+00:13:01,450 --> 00:13:05,190
+ثم نقف على ال loop ثم نقف على ال neighbors ثم نقف
+
+158
+00:13:05,190 --> 00:13:09,250
+على ال neighbors ثم نقف على ال neighbors ثم نقف
+
+159
+00:13:09,250 --> 00:13:12,330
+على ال neighbors ثم نقف على ال neighbors ثم نقف
+
+160
+00:13:12,330 --> 00:13:13,210
+على ال neighbors ثم نقف على ال neighbors ثم نقف
+
+161
+00:13:13,210 --> 00:13:17,330
+على ال neighbors ثم نقف على ال neighbors ثم نقف
+
+162
+00:13:17,330 --> 00:13:18,670
+على ال neighbors ثم نقف على ال neighbors ثم نقف
+
+163
+00:13:18,670 --> 00:13:24,250
+على ال neighbors ثم نقفالـ highest value و بنتقل
+
+164
+00:13:24,250 --> 00:13:33,050
+إليها إذا ال value هذا إذا ال number هذا أقل
+
+165
+00:13:33,050 --> 00:13:38,950
+من ال current أقل من ال current إذا هو أعلى واحد
+
+166
+00:13:38,950 --> 00:13:43,110
+فيهم يعني أنا هنا مثلا سبعة و أعلى واحد فيهم كان
+
+167
+00:13:43,110 --> 00:13:49,110
+خمسة إيش معنى ذلك يعني أعلى واحد فيالخيارات
+
+168
+00:13:49,110 --> 00:13:54,970
+المتاحة اللي لسه أقل مني يبقى في
+
+169
+00:13:54,970 --> 00:14:00,570
+إيش تمام؟ ال algorithm مش تمام؟ الروح بيختار نفسها
+
+170
+00:14:00,570 --> 00:14:02,910
+ليش بيختارها إذا كانت أسوأ من اللي أنا و عارف
+
+171
+00:14:02,910 --> 00:14:07,710
+عليه؟ هو تقييم مش معناته أعلى، ان هو أقل، بيختار
+
+172
+00:14:07,710 --> 00:14:10,770
+لأقل اللي بيجربنا إذا ال value تبع ال neighbors
+
+173
+00:14:10,770 --> 00:14:15,410
+أنا اخترت أن أطلعك على ال neighbors و أختارت أفضل
+
+174
+00:14:15,410 --> 00:14:20,330
+واحد فيهمو كان أفضل واحد فيهم أقل مني أنا هنا سبعة
+
+175
+00:14:20,330 --> 00:14:23,610
+بطلع
+
+176
+00:14:23,610 --> 00:14:29,550
+خلاص بنهي مافيش مجال أتحرك بنهي و بقول ان ال ..
+
+177
+00:14:29,550 --> 00:14:33,950
+اللي لا ناجيته هو ال current هذا ال current هذا هو
+
+178
+00:14:33,950 --> 00:14:38,790
+goal ولا مش goal ال algorithm مابخسهاش لأنه هي
+
+179
+00:14:38,790 --> 00:14:45,330
+مابتقدرش تعمل أكتر من ايه صح؟ وإلا إذا مش أجل يبقى
+
+180
+00:14:45,330 --> 00:14:51,580
+إماأقل أو يساوي يا ناسي إذا أقل أو يساوي احتجازك
+
+181
+00:14:51,580 --> 00:14:55,800
+إذا أحسن ال neighbor هذا اللي أحسن افترض ان انا
+
+182
+00:14:55,800 --> 00:15:01,000
+سبعة و الأحسن كانت تسعة ال neighbor هذا اللي تسعة
+
+183
+00:15:01,000 --> 00:15:06,440
+هو اللي بصير current و بستمر بستمر في اللوبي ماشي
+
+184
+00:15:06,440 --> 00:15:12,140
+بخرج من اللوبي إذا كان أفضل واحد في المتاحين أقل
+
+185
+00:15:12,140 --> 00:15:22,140
+أو يساوي من اللي ..من ال current طبعا هذا
+
+186
+00:15:22,140 --> 00:15:27,500
+الكلام فيه عليه عيوب أو عيبه الأساسي اللي هو ال
+
+187
+00:15:27,500 --> 00:15:34,320
+local minima هل تفكر ان هذول ايش local minima هي
+
+188
+00:15:34,320 --> 00:15:38,620
+ال algorithm هتخرج اذا وصلت لها لنغارة هتخرج بس
+
+189
+00:15:38,620 --> 00:15:42,340
+بدون ما تكون وصلت لمن لل global minima او لل
+
+190
+00:15:42,340 --> 00:15:49,220
+global maximumفاحنا الآن بنتطلع على variants أو
+
+191
+00:15:49,220 --> 00:15:53,040
+بدائل أو تغييرات في ال hill climbing algorithm
+
+192
+00:15:53,040 --> 00:15:58,000
+اللي تخليها ربما تخرج من هذه المطابات أو من هذه ال
+
+193
+00:15:58,000 --> 00:16:02,920
+local minima بس بالأول بنتطلع على المثال هذا اللي
+
+194
+00:16:02,920 --> 00:16:11,080
+هو ال eight queens اللغة بهذه اذا حدا مرت عليه و
+
+195
+00:16:11,080 --> 00:16:15,120
+اتخيلها هذا المثال و احنا بنحكي كمان شويةإن انت
+
+196
+00:16:15,120 --> 00:16:17,920
+هنا في اللعبة هذه الهدف طبعا اللعبة هذه ممكن تبقى
+
+197
+00:16:17,920 --> 00:16:22,060
+eight وممكن تبقى four بمعنى ان اللوحة تكون اربع
+
+198
+00:16:22,060 --> 00:16:29,000
+اربع فاربع فقط او
+
+199
+00:16:29,000 --> 00:16:32,520
+تمانية في تمانية او ماعليه دالي الهدف في اللعبة
+
+200
+00:16:32,520 --> 00:16:37,540
+هذه ان انا انحط ال queens هذه بحيث انه مايبقاش في
+
+201
+00:16:37,540 --> 00:16:43,800
+two او more queens مشتركين في افقي او عمودي او
+
+202
+00:16:43,800 --> 00:16:48,420
+دلوقتييعني مثلا هنا هدولة ماشيين على او قاعدين على
+
+203
+00:16:48,420 --> 00:16:56,320
+نفس الأفق صح وهذا مرفوض لازم تتحرك تنتين و يعني
+
+204
+00:16:56,320 --> 00:16:59,680
+هذا مثلا ينجلق هنا وهذا ينجلق في مكان تاني بحسب
+
+205
+00:16:59,680 --> 00:17:03,880
+انه مايضالش على هذا الخط الا واحد كذلك الحالة في
+
+206
+00:17:03,880 --> 00:17:09,360
+الأعمدة هنا في الأعمدة مافيش شي صح انما في الأسطر
+
+207
+00:17:09,360 --> 00:17:13,650
+و بعدين في الدابرة هذا الدابرة المرفوض ماشيهذا
+
+208
+00:17:13,650 --> 00:17:18,370
+عبارة عن أياش solution صح هي على الأعمدة مافيش إلا
+
+209
+00:17:18,370 --> 00:17:21,590
+واحدة وعلى القصد ومافيش إلا واحدة وعلى ال diagonal
+
+210
+00:17:21,590 --> 00:17:26,750
+مافيش .. يعني ال diagonal فيه نعم لو تتخيلها 9 في
+
+211
+00:17:26,750 --> 00:17:31,970
+9 مظبوطش تخليها 9 في 9 مافينا 9 في 9 اه انت تخليها
+
+212
+00:17:31,970 --> 00:17:36,130
+9 في 9 اه عدد اللي هذا عدد ال queens يساوي ال
+
+213
+00:17:36,130 --> 00:17:40,030
+dimensions يساوي ال dimensions فانت ممكن تبقى 4 في
+
+214
+00:17:40,030 --> 00:17:45,710
+4 تبقى 8 في 8 7 في 7المهم الهدف انه ال system لو
+
+215
+00:17:45,710 --> 00:17:49,050
+بدك تعطيله ال system يساوي هذا الكلام مبدأيا هو
+
+216
+00:17:49,050 --> 00:17:53,970
+هبرمى queens randomly بس بحيث ان كل queen تيجي في
+
+217
+00:17:53,970 --> 00:17:59,050
+عمض لحان عشان يضمن ان مافيش شيء بس بعد كهل اللي
+
+218
+00:17:59,050 --> 00:18:05,570
+رماهم في الأعمد المختلفة صدف انه في مشتركين في صدر
+
+219
+00:18:05,570 --> 00:18:06,870
+واحد اللي لأ بده يفحص
+
+220
+00:18:11,720 --> 00:18:15,180
+طبعا في عندنا هنا في الحالة هذه في عندنا إشكالي
+
+221
+00:18:15,180 --> 00:18:19,260
+اللي هو أن هاي مثلا أربعة مشتركين في دررنا و هاي
+
+222
+00:18:19,260 --> 00:18:22,480
+تلاتة مشتركين في دررنا و هاي اتنين مشتركين في
+
+223
+00:18:22,480 --> 00:18:28,440
+دررنا ماشي الان ال system أمامه أنه يحرك هذا state
+
+224
+00:18:28,440 --> 00:18:32,280
+ينتقل منها إلى state أخرى فكل state كل state أخرى
+
+225
+00:18:32,280 --> 00:18:36,200
+ممكن اللي يعملها تنتج عن تنتجت حركة إحدى ال quiz
+
+226
+00:18:36,200 --> 00:18:42,500
+إما إلى مكان واحد من هذه الأماكنفي الأعمدة يعني
+
+227
+00:18:42,500 --> 00:18:47,280
+الكوين هذه ممكن تتقل هنا او هنا او هنا او هنا او
+
+228
+00:18:47,280 --> 00:18:51,760
+هنا او هنا او هنا او هنا صح؟ صح هذا one هي الكوين
+
+229
+00:18:51,760 --> 00:18:54,900
+هذه لحدها الكوين هذه امامها برضه كذلك هال هذا
+
+230
+00:18:54,900 --> 00:18:58,420
+العدد من ال options لأن الأقام هذه هي عمليا
+
+231
+00:18:58,420 --> 00:19:03,340
+التقييم تبع ال move لو هى انتقلت هنا الخمساش هذا
+
+232
+00:19:03,340 --> 00:19:10,320
+بيقولى اكم conflict هيحصي تمام؟ اذا انا نجرتالكوين
+
+233
+00:19:10,320 --> 00:19:15,120
+من هنا لهنا واحد جداش هو الآن عدد ال conflicts في
+
+234
+00:19:15,120 --> 00:19:19,040
+هذه الحالة واحد هاي conflict اتنين تلاتة هاي تلاتة
+
+235
+00:19:19,040 --> 00:19:23,620
+في ال conflicts صح وهاي كمان two conflicts تعاوضين
+
+236
+00:19:23,620 --> 00:19:28,880
+خمسة هاي خمسة و بعدين أيش كمان هاي ستة و بعدين
+
+237
+00:19:28,880 --> 00:19:36,260
+اربعة مصبوط هدول اربعة و اين كمان هاي كمان اتنين و
+
+238
+00:19:36,260 --> 00:19:40,190
+هاي كمان اتنين و هاي كمانففي هذه في المجموعة في
+
+239
+00:19:40,190 --> 00:19:44,330
+تقريبا أظن في هذه اللوحة سبعتاشر conflict المهم
+
+240
+00:19:44,330 --> 00:19:48,190
+أنه لو انتقلت من هنا إلى هنا العدد ال conflicts
+
+241
+00:19:48,190 --> 00:19:52,290
+هيصير خمستاشر لماذا؟ لأن هيته هذا هيروح هذا ال
+
+242
+00:19:52,290 --> 00:19:57,250
+conflict تيجي هذا بداله صح؟ لو انتقلت إلى هنا
+
+243
+00:19:57,250 --> 00:20:00,970
+هيروح هذا ال conflict وهذا هصير مش في conflict
+
+244
+00:20:00,970 --> 00:20:03,790
+فهيجيله هصير أربعتاشر لو انتقلت إلى هنا برضه
+
+245
+00:20:03,790 --> 00:20:06,710
+اربعتاشر لو انتقلت إلى هنا هصير تمطعش لأنه راح
+
+246
+00:20:06,710 --> 00:20:11,050
+conflict و أجي بدالهخمسة conflicts، مظبوط؟
+
+247
+00:20:11,050 --> 00:20:14,890
+فالأرقام هذه عدد ال conflicts إحنا الآن بدنا عدد
+
+248
+00:20:14,890 --> 00:20:18,590
+ال conflicts يزيد ولا يجل؟ يجل يصبح إلى zero ال
+
+249
+00:20:18,590 --> 00:20:23,490
+goal تبعنا هو state أن نصل إلى state عدد ال
+
+250
+00:20:23,490 --> 00:20:28,190
+conflicts فيها صفر يعني أنا ببحث عن local minima،
+
+251
+00:20:28,190 --> 00:20:31,930
+مظبوط؟ local minima ال optimization مقصود بإيما
+
+252
+00:20:31,930 --> 00:20:35,690
+أصولي إلى ال global maximum أو ال global minimum،
+
+253
+00:20:35,690 --> 00:20:39,440
+مظبوط؟ هي ال optimizationفاحنا الأن في اللعبة هذه
+
+254
+00:20:39,440 --> 00:20:45,480
+ال system هييجي يبدأ في لوحة عشوائية و بعدين ايش
+
+255
+00:20:45,480 --> 00:20:50,960
+يفرع منها كل possible moves فمن possible moves عسب
+
+256
+00:20:50,960 --> 00:20:55,900
+عدد اللعبة إذا أما تسعة كل واحدة إلها تمانية
+
+257
+00:20:55,900 --> 00:21:03,760
+خيارات و هم تسعة queens تسعة في تمانيةده معناه عدد
+
+258
+00:21:03,760 --> 00:21:08,160
+من ال children بده يقيم كل واحد من ال children في
+
+259
+00:21:08,160 --> 00:21:10,660
+هذه الهي انا objective function او evaluation
+
+260
+00:21:10,660 --> 00:21:14,020
+function او fitness function سميها ايش ما بدك
+
+261
+00:21:14,020 --> 00:21:19,120
+fitness objective
+
+262
+00:21:19,120 --> 00:21:22,740
+evaluation
+
+263
+00:21:22,740 --> 00:21:26,440
+function
+
+264
+00:21:26,440 --> 00:21:32,410
+هتاخد ال state و بتقول ليالـ state هذه جداش قيمتها
+
+265
+00:21:32,410 --> 00:21:36,630
+جداش عدد ال conflicts اللي فيها الـ state التاني
+
+266
+00:21:36,630 --> 00:21:42,910
+لو أنا نجلت هذا هنا جداش بطلع مظبوط هذا المنظر دمش
+
+267
+00:21:42,910 --> 00:21:47,730
+كل ال states في لوحة واحدة ومعطيني الأقصى انت بقى
+
+268
+00:21:47,730 --> 00:21:52,010
+واضح فالان ال algorithm بنهاشي ال hill climbing
+
+269
+00:21:52,010 --> 00:21:57,530
+algorithm تفرض هذا الفضاء الاحتمالاتو تقيمه و
+
+270
+00:21:57,530 --> 00:22:02,750
+تنتقل إلى ال state اللي أفضل ثم منها إلى الأفضل ثم
+
+271
+00:22:02,750 --> 00:22:05,850
+منها إلى الأفضل الأفضل يعني هبوطا إلى ال zero
+
+272
+00:22:05,850 --> 00:22:11,190
+conflict تمام فهذا الآن انت ممكن تتخيل ال hill
+
+273
+00:22:11,190 --> 00:22:13,670
+climbing algorithm كيف ممكن تشغل على ال problem
+
+274
+00:22:13,670 --> 00:22:16,310
+هذه طيب الآن احنا بقول ان عيش مشكلة ال hill
+
+275
+00:22:16,310 --> 00:22:20,730
+climbing algorithm اللي هي انك تصل إلى state كل
+
+276
+00:22:20,730 --> 00:22:27,520
+المتفرع منها أسوأ منها أسوأ أو يساويالان ايش
+
+277
+00:22:27,520 --> 00:22:33,120
+المخارج الممكنة من هذا الامر ال variance هنا اللي
+
+278
+00:22:33,120 --> 00:22:35,860
+هو انه احنا نعمل تعديلات على ال algorithm بحيث
+
+279
+00:22:35,860 --> 00:22:39,960
+انها ربما تخرج منه ال stochastic hill climbing انه
+
+280
+00:22:39,960 --> 00:22:45,440
+احنا لما تصل الى minima اه ال local minima مش تخرج
+
+281
+00:22:45,440 --> 00:22:51,230
+ايه شو تروح تسويتاخد حلول محددة اي واحد من اللي
+
+282
+00:22:51,230 --> 00:22:56,310
+حواليها و تقفز اليه بغض النظر بغض النظر ان هو أسوأ
+
+283
+00:22:56,310 --> 00:23:02,950
+او لا تمام هذا خروجا من ال .. من ال local minima
+
+284
+00:23:02,950 --> 00:23:07,630
+لأن اذا انا وقفت على ال state ال state هذه كل اللي
+
+285
+00:23:07,630 --> 00:23:14,350
+حواليها أسوأ منها و هي مش goal تمام ماليش مخرج الا
+
+286
+00:23:14,350 --> 00:23:19,470
+ان اغمض عليا و انط نطةعلى أي .. أقفز قفزة على أي
+
+287
+00:23:19,470 --> 00:23:23,830
+location أخر ربما هذه ال location ألاقي حوالين منه
+
+288
+00:23:23,830 --> 00:23:31,920
+steps درجات تدرجني لفوق باسم أختار أفضل الأسوأأفضل
+
+289
+00:23:31,920 --> 00:23:37,480
+أسوأ مانا برضه أفضل أسوأ هذا ما هو كونه هو أفضل
+
+290
+00:23:37,480 --> 00:23:42,220
+أسوأ هذا لا يعني أنه مؤدي إلى الأفضل يعني أنا
+
+291
+00:23:42,220 --> 00:23:46,740
+مابعرفش ما ممكن أفضل أسوأ أفضل أسوأ زي اللي أنا
+
+292
+00:23:46,740 --> 00:23:50,920
+واقف عليها يبقى برضه اللي حواليه كلهم يعني مافي ..
+
+293
+00:23:50,920 --> 00:23:54,860
+مافي أفضلية أن هو أفضل أسوأ ولا أسوأ أسوأ كلهم
+
+294
+00:23:54,860 --> 00:24:00,790
+بالآخر بالنسبة إيه ديالأمر blind بالنسبالي ضبابي
+
+295
+00:24:00,790 --> 00:24:04,350
+مش عارف ايوة فال stochastic هنا probabilistic
+
+296
+00:24:04,350 --> 00:24:08,850
+probability باخد عشوائي ان انا على ال probability
+
+297
+00:24:08,850 --> 00:24:15,470
+باخد عشوائي اي واحد تمام ال first
+
+298
+00:24:15,470 --> 00:24:24,950
+choice hill climbing انه انا اضلني اجرب في اللي
+
+299
+00:24:24,950 --> 00:24:32,690
+حوليالحد ما انا اخد اول
+
+300
+00:24:32,690 --> 00:24:47,790
+افضل واحد لحد
+
+301
+00:24:47,790 --> 00:24:53,210
+ما انا اخد اول افضل واحد لحد ما انا اخد اول افضل
+
+302
+00:24:53,210 --> 00:25:00,480
+واحدfirst choice بمعنى أنه أفضل أخدهم عشوائيا ده
+
+303
+00:25:00,480 --> 00:25:11,900
+هتتملأجي واحد أفضل من اللي معاه التالت
+
+304
+00:25:11,900 --> 00:25:16,380
+الخيار التالت أنه أنا أبدأ بداية جديدة تماما
+
+305
+00:25:16,380 --> 00:25:24,140
+random restart احنا بيكون بدأنا من random state
+
+306
+00:25:24,920 --> 00:25:28,980
+اللي هي start state ومشينا وصلنا لل local minima
+
+307
+00:25:28,980 --> 00:25:34,640
+وقفنا مش عارفين نكمل خلاص بنسي هذي و ببدأ بداية
+
+308
+00:25:34,640 --> 00:25:43,880
+جديدة بداية جديدة ب start state عشوائية جديدة
+
+309
+00:25:43,880 --> 00:25:50,680
+تمام
+
+310
+00:25:50,680 --> 00:25:56,220
+فاحنا الآن عملياصار عندنا فكرة عن ال hill climbing
+
+311
+00:25:56,220 --> 00:26:03,780
+وصار عندنا فكرة عن اللي هو البدائل المطوحة لإخراج
+
+312
+00:26:03,780 --> 00:26:08,800
+ال algorithm من ورطلة اللي هو ال local minima تلت
+
+313
+00:26:08,800 --> 00:26:12,780
+بدائل هدولة اما ال stochastic hill climbing يعني
+
+314
+00:26:12,780 --> 00:26:18,060
+ان اخد random حتى لو كان سيئالأولى هي ان انا
+
+315
+00:26:18,060 --> 00:26:23,740
+بالاصل لما بانتقل بجرب باطلع على الاطفال واحد واحد
+
+316
+00:26:23,740 --> 00:26:31,960
+و باخد الأفضل random و الخيار التالت انه اذا لما
+
+317
+00:26:31,960 --> 00:26:36,400
+ال algorithm تجع في local minima اللي هو انه state
+
+318
+00:26:36,400 --> 00:26:40,080
+مش goal و كل اللي حوالها أسوأ منها بعمل restart
+
+319
+00:26:40,080 --> 00:26:44,160
+لكل ال algorithm من جديد و ببدأ ب random
+
+320
+00:26:48,140 --> 00:26:52,480
+الان احنا في معانا دوبك خمس دقايق نبدأ فيهم و نحكي
+
+321
+00:26:52,480 --> 00:26:56,060
+فيهم على algorithm اخرى all together مختلفة اللي
+
+322
+00:26:56,060 --> 00:26:58,500
+هي simulated learning
+
+323
+00:27:02,230 --> 00:27:05,690
+بيظل معانا وجدت بنكمل بنحكي في الـ Local Beam
+
+324
+00:27:05,690 --> 00:27:09,730
+Algorithm ال simulated annealing مبساطة شديدة ان
+
+325
+00:27:09,730 --> 00:27:14,830
+احنا فيها خصائص بعض خصائص ال hair climbing ان احنا
+
+326
+00:27:14,830 --> 00:27:21,970
+بالاصل بنعمل random selection لواحد من ال
+
+327
+00:27:21,970 --> 00:27:23,850
+successors
+
+328
+00:27:28,960 --> 00:27:32,580
+وبذاك الجلوب هذه Randomly select successor of
+
+329
+00:27:32,580 --> 00:27:36,740
+current هاي ال current ويلها عدة successors نختار
+
+330
+00:27:36,740 --> 00:27:42,540
+واحدة منهم at random ونسميه هو next ال next هذا
+
+331
+00:27:42,540 --> 00:27:45,900
+بنشوف
+
+332
+00:27:45,900 --> 00:27:50,560
+هل هو أحسن و لا أسوأ من هذا عشوائي نحن اختارناه
+
+333
+00:27:50,560 --> 00:27:55,680
+نشوف هو أحسن و لا أسوأ المفروض إذا هو أسوأ أنا
+
+334
+00:27:55,680 --> 00:28:04,980
+ماتطلعش عليهالمفروض بس أخده إذا هو أفضل دلتا
+
+335
+00:28:04,980 --> 00:28:08,900
+E هذه هي عبارة عن الفرق ما بين ال next و ما بين ال
+
+336
+00:28:08,900 --> 00:28:11,900
+current next نقص current إذا next أكبر من current
+
+337
+00:28:11,900 --> 00:28:17,880
+تتجه دلتا E هذه موجة بأكبر من ال zero ففي هذه
+
+338
+00:28:17,880 --> 00:28:24,560
+الحالة إذا دلتا E أكبر من zero على طول بخل ال next
+
+339
+00:28:24,560 --> 00:28:29,110
+هو ال current بنتقل إليهطيب إذا مش أقل المفروض
+
+340
+00:28:29,110 --> 00:28:36,390
+أقنشه لأ بقنشوش ممكن أخليه هو ال current بناء على
+
+341
+00:28:36,390 --> 00:28:43,850
+probability probability احتمالي تمام ال E to delta
+
+342
+00:28:43,850 --> 00:28:47,950
+ال
+
+343
+00:28:47,950 --> 00:28:53,750
+exponential مرفوعة ل delta E اللي هو الفرق على T T
+
+344
+00:28:53,750 --> 00:29:02,740
+هنا capital هي عبارة عنقيمة بتبدأ وبتتناقص تبدأ
+
+345
+00:29:02,740 --> 00:29:07,740
+عالية وبتتناقص مع
+
+346
+00:29:07,740 --> 00:29:14,360
+الزمن او مع ال iterations يعني في ال iteration
+
+347
+00:29:14,360 --> 00:29:17,440
+الأولى تبقى T عالية اللي بعدها .. اللي بعدها ..
+
+348
+00:29:17,440 --> 00:29:22,180
+اللي بعدها .. T بتتناقص واضح ال plot هذا ال plot
+
+349
+00:29:22,180 --> 00:29:27,100
+هو يوثل اللي قلتلكم بين T كمتل وبين I هنا Iش ال
+
+350
+00:29:27,100 --> 00:29:27,540
+iterations
+
+351
+00:29:30,230 --> 00:29:39,050
+تسمول تسمول تسمول تسمول تسمول
+
+352
+00:29:39,050 --> 00:29:39,330
+تسمول تسمول تسمول تسمول تسمول تسمول تسمول تسمول
+
+353
+00:29:39,330 --> 00:29:44,210
+تسمول تسمول تسمول تسمول تسمول تسمول تسمول تسمول
+
+354
+00:29:44,210 --> 00:29:44,490
+تسمول تسمول تسمول تسمول تسمول تسمول تسمول تسمول
+
+355
+00:29:44,490 --> 00:29:44,870
+تسمول تسمول تسمول تسمول تسمول تسمول تسمول تسمول
+
+356
+00:29:44,870 --> 00:29:48,370
+تسمول تسمول تسمول تسمول تسمول تسمول تسمول تسمول
+
+357
+00:29:48,370 --> 00:29:48,490
+تسمول تسمول تسمول تسمول تسمول تسمول تسمول تسمول
+
+358
+00:29:48,490 --> 00:29:55,290
+تسمول تسمول تسمول تسمول
+
+359
+00:29:55,290 --> 00:30:05,800
+تسمول تسممبدأ يكبر صح لما T تتناقص كلما كبر ال E
+
+360
+00:30:05,800 --> 00:30:09,540
+هذا او
+
+361
+00:30:09,540 --> 00:30:14,600
+كل ال function ال exponential function لما انا
+
+362
+00:30:14,600 --> 00:30:22,800
+برفعها أس كلما بكبر الأس هذا بيصغر تمام فايش بيصير
+
+363
+00:30:22,800 --> 00:30:28,850
+ال probability بتجللـ probability مع الزمن مع عدد
+
+364
+00:30:28,850 --> 00:30:33,070
+ال iterations بيبدأ هذا النقطة ينخفض فإذا انخفضت
+
+365
+00:30:33,070 --> 00:30:37,230
+ال probability بيصير الاحتمال ان انا اخدها على
+
+366
+00:30:37,230 --> 00:30:41,910
+الرغم من انها سيئة بيصير اضعف انما في أول ال
+
+367
+00:30:41,910 --> 00:30:45,850
+algorithm في أول ال iterations تجاوزت جدا ان انا
+
+368
+00:30:45,850 --> 00:30:53,430
+ممكن اخد ال neighbor انتقل
+
+369
+00:30:53,430 --> 00:30:59,150
+اليها على الرغم من انها عايش سيئةOkay احنا ليش
+
+370
+00:30:59,150 --> 00:31:03,870
+بنقول هذا ال condition هذا انا بدي اخد ال neighbor
+
+371
+00:31:03,870 --> 00:31:08,110
+على الرغم من انها سيئة على الرغم من انه اقل من
+
+372
+00:31:08,110 --> 00:31:11,810
+اللي انا واجه عليه هذا الأمر راجع لاحتمالية و
+
+373
+00:31:11,810 --> 00:31:15,910
+الاحتمالية بتتنقص مع الزمن بتبقى عالية في بداية ال
+
+374
+00:31:15,910 --> 00:31:21,790
+iterations و بتنخفض مع الزمن يبقى انا في بداية ال
+
+375
+00:31:21,790 --> 00:31:26,450
+algorithm ممكن و انا هنا مثلا start انا قيمتها 7
+
+376
+00:31:26,990 --> 00:31:32,090
+وعندى اخد random child اللى هو مين ال next وعشان
+
+377
+00:31:32,090 --> 00:31:36,790
+اطلع عن ال next انا جيه خمسة تمام المفروض مانتقلش
+
+378
+00:31:36,790 --> 00:31:41,630
+اليه لكن انا لانى لسه في بداية الشغل وفي بداية
+
+379
+00:31:41,630 --> 00:31:47,290
+الشغل ال T كبيرة كبيرة فهذا المقام كبير وبالتالي
+
+380
+00:31:47,290 --> 00:31:51,070
+المقدار هذا صغير وبالتالي هذا بيبقى عالى ال
+
+381
+00:31:51,070 --> 00:31:57,650
+exponential عالى فممكن يبقى للمحتمالية 90%تمام
+
+382
+00:31:57,650 --> 00:32:04,650
+فاتم هذا الإجراء اللي هو أنت في ال اليل لكن جدّام
+
+383
+00:32:04,650 --> 00:32:08,750
+الاحتمالية تبقى ضعفة تصير ال 9% ممكن تصل ل 10% أو
+
+384
+00:32:08,750 --> 00:32:14,710
+5% واضح فهذا ال simulated annealing بيسمح
+
+385
+00:32:14,710 --> 00:32:20,290
+بالانتقال إلى نود سيئة تمام أنه أنا مانديش أستمر
+
+386
+00:32:20,290 --> 00:32:25,690
+في الصعود ممكن أصعد أصعد و بعد ذلك أنزل هذا الصعود
+
+387
+00:32:25,690 --> 00:32:31,380
+و النزوليحسن أداء ال algorithm في الوصول إلى ال
+
+388
+00:32:31,380 --> 00:32:38,860
+global maximum فكله بيتمد على هذا المقدار اللي
+
+389
+00:32:38,860 --> 00:32:45,460
+بيتمد على الزمن هذا ال schedule هو فاكر فيها كإنها
+
+390
+00:32:45,460 --> 00:32:51,740
+عبارة عن array ال array هذه فيها أرقام الأرقام هذه
+
+391
+00:32:51,740 --> 00:32:59,840
+بتتناقص95 كانت تتنقص فانا على iteration T بتساوي
+
+392
+00:32:59,840 --> 00:33:15,720
+one هاخد رقم كبير على T هي هنا هي T هي T
+
+393
+00:33:15,720 --> 00:33:21,120
+وهي schedule of T T صغيرة بياخد رقم كبير T كل ما
+
+394
+00:33:21,120 --> 00:33:26,380
+تكبر T small بيصغر منالـ Schedule الـ Value تبعها
+
+395
+00:33:26,380 --> 00:33:31,020
+طبعا هنا التناقص ممكن يبقى خطي و ممكن يبقى التناقص
+
+396
+00:33:31,020 --> 00:33:37,200
+برضه كمان عاشر curve مش ضروري يبقى خطي المهم انت
+
+397
+00:33:37,200 --> 00:33:42,460
+تخيله عبارة عن قيم تتناقص و تناقصها بيضعف
+
+398
+00:33:42,460 --> 00:33:49,520
+الاحتمالية صح الاحتمالية ان انا اخد note اسوأ من
+
+399
+00:33:49,520 --> 00:33:52,920
+اللي انا فيهاالمفروض ان انا مااخدش بس هذا وارد و
+
+400
+00:33:52,920 --> 00:33:56,920
+احتماليته بتتناقص في الأول بتبقى عالية في مدينة
+
+401
+00:33:56,920 --> 00:34:01,640
+الشغل و بتتناقص جدا تمام؟ بنكمل المحاضرة الجاية و
+
+402
+00:34:01,640 --> 00:34:04,460
+بنحكي في ال local beam search
+
diff --git a/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/vx9l8pHNUU8_raw.srt b/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/vx9l8pHNUU8_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..11461d796598335431cee2a56cee144c40cb5789
--- /dev/null
+++ b/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/vx9l8pHNUU8_raw.srt
@@ -0,0 +1,1644 @@
+1
+00:00:20,720 --> 00:00:25,920
+بسم الله الرحمن الرحيم محاضرة اليوم تكملة لموضوع
+
+2
+00:00:25,920 --> 00:00:34,260
+ال informed search ماشي احنا في chapter أربعة
+
+3
+00:00:34,260 --> 00:00:39,800
+بدينا في موضوع ال informed search كان ال
+
+4
+00:00:39,800 --> 00:00:43,980
+algorithmات اللي شفناها قبل هيكة اللي هم ال a star
+
+5
+00:00:43,980 --> 00:00:50,680
+algorithm كانت بتحكي عن اللي هو البحث عن ال goalأو
+
+6
+00:00:50,680 --> 00:00:54,320
+الهدف منها كان البحث عن ال goal و بأقصر مسار بأقصر
+
+7
+00:00:54,320 --> 00:01:01,560
+مسار في مسائل يكون الهدف هو ال goal و المسار مش
+
+8
+00:01:01,560 --> 00:01:06,640
+مهم المسار مش مهم ففي هذه الحلقة بسميها ال search
+
+9
+00:01:06,640 --> 00:01:14,140
+بسميه local search في ال chapter هذا ال section
+
+10
+00:01:14,140 --> 00:01:16,560
+الأولية اللي من أربعة اللي هو أربعة واحد local
+
+11
+00:01:16,560 --> 00:01:19,550
+search algorithmalgorithms and optimization
+
+12
+00:01:19,550 --> 00:01:23,210
+problems فاحنا الآن المحاضرة دي بنطلع على هذا
+
+13
+00:01:23,210 --> 00:01:26,230
+النوع من ال search algorithms اللي هو ال local
+
+14
+00:01:26,230 --> 00:01:36,870
+search algorithms وبالتحديد
+
+15
+00:01:36,870 --> 00:01:41,850
+فيها ان اللي هم التلاتة دولة hill climbing
+
+16
+00:01:46,750 --> 00:01:50,890
+و Simulated Annealing
+
+17
+00:01:50,890 --> 00:02:03,010
+و Local Beam Search الـ
+
+18
+00:02:03,010 --> 00:02:08,270
+Genetic Algorithm جاي هنا تحت هذا الفئة لكن احنا
+
+19
+00:02:08,270 --> 00:02:14,320
+هنشوفها قدام بعد هناموجودة و مقتضب جدا نحكي عنها
+
+20
+00:02:14,320 --> 00:02:18,740
+احنا هنشوفها قدام بالتفصيل اكتر من ال textbook
+
+21
+00:02:18,740 --> 00:02:22,940
+التاني تمام من الكتاب التاني باقي ال sections اللي
+
+22
+00:02:22,940 --> 00:02:28,380
+في chapter 4 مش هنطلع عليها بيكفينا هذا النوع من
+
+23
+00:02:28,380 --> 00:02:32,240
+ال search الان ال local search في chapter 5 بنشوف
+
+24
+00:02:32,240 --> 00:02:35,460
+ال adversarial search اللي هو ال search اللي بيكون
+
+25
+00:02:35,460 --> 00:02:40,340
+في games و ال games هذه فيها تنافس ما بين برافين
+
+26
+00:02:41,220 --> 00:02:46,520
+Okay فالان احنا في ال local search algorithms نشوف
+
+27
+00:02:46,520 --> 00:02:51,080
+اول محلل هو ال hill climbing search ال hill
+
+28
+00:02:51,080 --> 00:02:54,660
+climbing search من اسمها او خلينا جبه نشوف ال
+
+29
+00:02:54,660 --> 00:02:59,000
+algorithm نطلع على الرسم هادي بتوضح قلية عمل ال ..
+
+30
+00:02:59,000 --> 00:03:03,400
+او بناخد فكرة عن .. فكرة ال algorithm انه احنا ال
+
+31
+00:03:03,400 --> 00:03:09,440
+.. ال .. ال node او ال algorithm بتدفع على node و
+
+32
+00:03:09,440 --> 00:03:14,800
+بتشوف ايشchildren بتفرع منها بتتطلع على ال
+
+33
+00:03:14,800 --> 00:03:21,700
+children هدولة و تاخد أفضل واحدة طبعا الان ممكن
+
+34
+00:03:21,700 --> 00:03:29,460
+تصل في وجهة من الأوجات يعني دائما هذه الزمن
+
+35
+00:03:29,460 --> 00:03:36,760
+هيك طبعا stay space لما تبدأ على node واحدة يفترض
+
+36
+00:03:36,760 --> 00:03:40,720
+انها تاخد nodeلو تنتقل على ال node التاني يفترض أن
+
+37
+00:03:40,720 --> 00:03:44,060
+التاني أفضل منها في التقييم يعني إذا كانت هذه
+
+38
+00:03:44,060 --> 00:03:48,240
+التقييم تبعها تلاتة و هدولة ال children في منهم
+
+39
+00:03:48,240 --> 00:03:50,700
+الأتنين و في منهم الأربعة و في منهم الخمسة و في
+
+40
+00:03:50,700 --> 00:03:53,840
+منهم الستة و في منهم الستة و في منهم السبعة هي
+
+41
+00:03:53,840 --> 00:03:57,440
+هتاخد الأفضل ما بين ال children فانتقالها من ال
+
+42
+00:03:57,440 --> 00:04:03,900
+node إلى ال node يفترض بيعطيها سؤوة في جودة ال
+
+43
+00:04:03,900 --> 00:04:08,530
+node تنتقل من ال node الأسوأ إلى الأحسنفهنا ال
+
+44
+00:04:08,530 --> 00:04:11,470
+objective function اللي نفسط بيها انه ال objective
+
+45
+00:04:11,470 --> 00:04:13,810
+function هي ال function بتاعة التقييم لل node
+
+46
+00:04:13,810 --> 00:04:18,130
+فيفترض انه احنا كل ما تقدمت عملية ال search و فحصت
+
+47
+00:04:18,130 --> 00:04:22,830
+المزيد من ال nodes كل node تبقى افضل من اللي
+
+48
+00:04:22,830 --> 00:04:29,350
+جابلها يبقى احنا ياشهر بنصعد صعودا في جودة ال
+
+49
+00:04:29,350 --> 00:04:35,790
+nodes الهدف تبعنا انه اصل ال node الأفضل ال node
+
+50
+00:04:35,790 --> 00:04:39,120
+الأفضل من ناحية ايشمن ناحية ال objective من ناحية
+
+51
+00:04:39,120 --> 00:04:41,920
+التقييم يعني إيش من ناحية التقييم من ناحية قربها
+
+52
+00:04:41,920 --> 00:04:45,800
+من الهدف صح ولا لأنه إحنا التقييم عندنا المقصود
+
+53
+00:04:45,800 --> 00:04:50,880
+بيه إيش جداش هذه ال note بتقربني إلى الهدف فكل ما
+
+54
+00:04:50,880 --> 00:04:54,480
+كانت تقييم عالي .. عالي أنا مقصود مش بالقيمة عالية
+
+55
+00:04:54,480 --> 00:04:57,560
+يعني من ناحية الجوة .. أجوة ممكن يكون اللي أقل هو
+
+56
+00:04:57,560 --> 00:05:02,380
+اللي أفضل تمام فجودة ال note جودة ال note يعني
+
+57
+00:05:02,380 --> 00:05:07,640
+جداش بتقربني إلى الهدففانتقال ال algorithm من node
+
+58
+00:05:07,640 --> 00:05:10,360
+إلى اللي بعدها إلى اللي بعدها بغض النظر هي تتقل في
+
+59
+00:05:10,360 --> 00:05:14,460
+أي اتجاه المهم هي تنتقل من node إلى node انتقالها
+
+60
+00:05:14,460 --> 00:05:18,020
+من node إلى node يفترض أنه يعطيني جودة في التقييم
+
+61
+00:05:18,020 --> 00:05:21,940
+ال node اللي بنتقل إليها أفضل من السابق واضح هذا
+
+62
+00:05:21,940 --> 00:05:25,920
+الكلام لكن هذا الكلام مش دائما مضمون يعني ممكن تصل
+
+63
+00:05:25,920 --> 00:05:33,800
+ال algorithm إلى node ويبقى كل ال options المتاحة
+
+64
+00:05:33,800 --> 00:05:35,180
+إلها المتفرعة منها
+
+65
+00:05:38,240 --> 00:05:42,340
+زيها بالظبط يعني هي بتبقى خمسة و كل ال notes
+
+66
+00:05:42,340 --> 00:05:48,600
+المتفارعة منها تقيمهم خمسة أصبح ايش؟ أصبح هي الآن
+
+67
+00:05:48,600 --> 00:05:54,020
+في موضوع محلك سر محلك سر ايش يعني؟ يعني لو أخدت
+
+68
+00:05:54,020 --> 00:05:58,820
+هذا ولا هذا ولا هذا ولا هذا ولا هذا مش هتفرق طب
+
+69
+00:05:58,820 --> 00:06:03,590
+إيش السبب في الحالة هذه؟في الحالة هذه ال algorithm
+
+70
+00:06:03,590 --> 00:06:08,090
+نفسها تجف by default بتجف لأنه الاستمراري تبعتها
+
+71
+00:06:08,090 --> 00:06:12,590
+ان طالما انه في مجال لتحسين للانتقال الى state
+
+72
+00:06:12,590 --> 00:06:18,770
+افضل بنستمر مافيش مجال يبقى ليش بنجف فهذا الآن
+
+73
+00:06:18,770 --> 00:06:25,730
+ومثله زي و برضه هذا الكلام ومثله هذا الكلام لأ
+
+74
+00:06:25,730 --> 00:06:30,210
+ناسف هذا الكلامهذا الكلام معناته انت لو وقفت على
+
+75
+00:06:30,210 --> 00:06:34,430
+نقطة اللي حواليك او على نوت اللي حواليها او اللي
+
+76
+00:06:34,430 --> 00:06:41,590
+متفرع منها اما مثلها او
+
+77
+00:06:41,590 --> 00:06:47,090
+اسوأ لسه منها صح ولا لأ اذا انا واقف هنا اللي
+
+78
+00:06:47,090 --> 00:06:51,270
+جابلي اسوأ مني لان انا جاي منها و اللي بعدي اسوأ
+
+79
+00:06:51,270 --> 00:06:53,610
+يبقى فات فاهمة اللي هاد الحالة و فاهمة اللي هاد
+
+80
+00:06:53,610 --> 00:06:55,110
+الحالة و فاهمة اللي هاد الحالة اللي انا عايشه
+
+81
+00:06:55,110 --> 00:06:59,010
+يفترض ال algorithm تجفهدول الحالات بيسميهم local
+
+82
+00:06:59,010 --> 00:07:05,510
+minima أو local maxima عسب أنك بتبحث عن الأقل ولا
+
+83
+00:07:05,510 --> 00:07:09,410
+بتبحث عن الأعلى local أما ال global اللي هو ال
+
+84
+00:07:09,410 --> 00:07:13,450
+goal تبعك اللي هو الأفضل على الإطلاق ناشي اللي هو
+
+85
+00:07:13,450 --> 00:07:16,970
+أعلى واحد هذا الكلام انت ممكن ماتصلوش ال algorithm
+
+86
+00:07:16,970 --> 00:07:23,990
+ممكن تجف هنا تجف هنا و ت .. و ت .. و ت .. و ت .. و
+
+87
+00:07:23,990 --> 00:07:24,030
+ت .. و ت .. و ت .. و ت .. و ت .. و ت .. و ت .. و ت
+
+88
+00:07:24,030 --> 00:07:25,370
+.. و ت .. و ت .. و ت .. و ت .. و ت .. و ت .. و ت
+
+89
+00:07:25,370 --> 00:07:25,590
+.. و ت .. و ت .. و ت .. و ت .. و ت .. و ت .. و ت
+
+90
+00:07:25,590 --> 00:07:25,670
+.. و ت .. و ت .. و ت .. و ت .. و ت .. و ت .. و ت
+
+91
+00:07:25,670 --> 00:07:25,670
+.. و ت .. و ت .. و ت .. و ت .. و ت .. و ت .. و ت
+
+92
+00:07:25,670 --> 00:07:31,670
+.. و ت .. و تلماذا تضرب stop؟ لأنه مافي خيار
+
+93
+00:07:31,670 --> 00:07:38,390
+أفضل اللي جابلها أسوأ و اللي قدام كلهم مساوين
+
+94
+00:07:38,390 --> 00:07:45,170
+الجماعة بتجدد و هنا كذلك و هنا كذلك إذا هي هنا
+
+95
+00:07:45,170 --> 00:07:52,490
+تستمر في الصعود إذا هي هنا تستمر في الصعود فهذا
+
+96
+00:07:52,490 --> 00:07:57,530
+الكلام الآنالوضع هذا نسميه shoulder و الوضع هذا
+
+97
+00:07:57,530 --> 00:08:01,570
+نسميه plateau ايش الفرق ما بين ال shoulder و ال
+
+98
+00:08:01,570 --> 00:08:07,950
+plateau ان ال plateau من جبله و من بعده أسوأ ال
+
+99
+00:08:07,950 --> 00:08:11,630
+shoulder من جبله أسوأ لكن من بعده ممكن فيه أمل
+
+100
+00:08:11,630 --> 00:08:19,110
+نصعد ل maximum فانا في ال plateau او ال flat local
+
+101
+00:08:19,110 --> 00:08:23,470
+minimum لو استمرت
+
+102
+00:08:23,990 --> 00:08:26,910
+مافيش فايد اطلاقا يعني لو قلت انا مثلا ال
+
+103
+00:08:26,910 --> 00:08:31,230
+algorithm خليني اسمح لها انها تمشي ماشي تاخد هذا
+
+104
+00:08:31,230 --> 00:08:34,710
+هذه خمسة و ال node اللي بعدها خمسة ماشي الحالة و
+
+105
+00:08:34,710 --> 00:08:38,770
+ربما الخمسة هي اللي بتفرع منها كمان خمسات تمام
+
+106
+00:08:38,770 --> 00:08:43,010
+تستمر تسمح لها تستمر في الانتقال على الضغط من انه
+
+107
+00:08:43,010 --> 00:08:48,430
+مافيش تحسن معناه دالك احنا بنتوجه على الخط الأفقي
+
+108
+00:08:48,430 --> 00:08:49,410
+صح؟
+
+109
+00:08:51,440 --> 00:08:59,580
+هذا الخط يمثل ال notes في مقابل جودة ال notes انا
+
+110
+00:08:59,580 --> 00:09:04,300
+جاهز باستمر و هنا الجودة بتطلع معايا بس هنا انا
+
+111
+00:09:04,300 --> 00:09:08,940
+باستمر لكن الجودة ثابتة مظبوط و هنا كذلك انا
+
+112
+00:09:08,940 --> 00:09:14,810
+بعبرلك على هذا الكلام من فضل انه ال noteفحصة node
+
+113
+00:09:14,810 --> 00:09:17,290
+و ال node ده كانت خمسة و ال children اللي متفرعة
+
+114
+00:09:17,290 --> 00:09:20,430
+منها أضابط خمسة و اللي متفرعة منها خمسة خمسة و دلت
+
+115
+00:09:20,430 --> 00:09:24,430
+تنتقل من خمسة إلى خمسة على الرقم لإنه مافيه فرق
+
+116
+00:09:24,430 --> 00:09:32,110
+لكن جدام ربنا تحت تحت تحت بعد كده level أجت واحدة
+
+117
+00:09:32,110 --> 00:09:37,110
+خمسة و اتفرع منها إشي أفضل من الخمسة كل سبعة أو
+
+118
+00:09:37,110 --> 00:09:42,670
+عشرة وجهتها بتكون إيش طلعت من ال shoulderو قاعدة
+
+119
+00:09:42,670 --> 00:09:48,790
+بتاعش بتزيد في ال efficiency هذا مثال توضيحي فقط
+
+120
+00:09:48,790 --> 00:09:52,510
+لتعني ال morphine algorithm هذا algorithm بس لو
+
+121
+00:09:52,510 --> 00:09:57,830
+تطلع بس لو نزلت تتوقع تتوقع احنا ببساطة شديدة ال
+
+122
+00:09:57,830 --> 00:10:01,470
+hill climbing algorithm زي ما قلت انا انها تستمر
+
+123
+00:10:01,470 --> 00:10:07,290
+لحد اما تلاقي ال goal او يبقى مافيش داعي للاستمرار
+
+124
+00:10:07,290 --> 00:10:11,830
+ايش يعني مافيش داعي للاستمرار يعني اناواجف على
+
+125
+00:10:11,830 --> 00:10:17,570
+node ال node هذه قيمتها كذا وكل اللي متفرع منها
+
+126
+00:10:17,570 --> 00:10:22,330
+زيها أو أسوأ يبقى ليش .. يبقى كيف ده انتقل قالية
+
+127
+00:10:22,330 --> 00:10:26,230
+حركتها الوحيدة انه انتقل الى الأفضل ال hill
+
+128
+00:10:26,230 --> 00:10:30,730
+climbing اسم ال hill climbing يعني تساقط اه فانا
+
+129
+00:10:30,730 --> 00:10:35,550
+كنت على مستمرةبطلع حوليا وين في حجر اطلع عليه انا
+
+130
+00:10:35,550 --> 00:10:41,450
+بتسلق في تلة او في جبل وين في صخرة او حجر اطلع منه
+
+131
+00:10:41,450 --> 00:10:47,230
+لأعلى بخطي مالاقيتش لاجيت كل اللي حوليا نفس
+
+132
+00:10:47,230 --> 00:10:51,910
+المستوى او من هنا نزول و من هنا نزول يبقى بوقف هذه
+
+133
+00:10:51,910 --> 00:10:55,170
+قالية او ال strategy تبع حركة ال hill climbing
+
+134
+00:10:55,170 --> 00:10:55,770
+algorithm
+
+135
+00:10:58,700 --> 00:11:02,760
+بنقول أن قالية هذه فيها مشكلة لأنه ممكن و هي تصعد
+
+136
+00:11:02,760 --> 00:11:07,440
+تصعد تصعد تنتقل من node إلى node و الانتقال هذا
+
+137
+00:11:07,440 --> 00:11:11,480
+يبقى فيه صعود أو تحسن في جودة ال nodes إلى أن تصل
+
+138
+00:11:11,480 --> 00:11:15,620
+إلى node ال node هذه بتدخلها على خيارات الخيارات
+
+139
+00:11:15,620 --> 00:11:21,620
+كلها أما أسوأ أو مساوية يبقى تبقى اوتوماتيكية لل
+
+140
+00:11:21,620 --> 00:11:26,140
+algorithm هتجف هتجف بدون ما تكون لاجت ال goal وهذا
+
+141
+00:11:26,140 --> 00:11:33,720
+إيش معناته مشبلغة الخصائص مش إيش إذا وقفت و من غير
+
+142
+00:11:33,720 --> 00:11:39,360
+ما تلاقي ال goal مش complete بالظبط مش complete و
+
+143
+00:11:39,360 --> 00:11:43,700
+عدم ال completeness هي رجايم إما إما تجه تهلك في
+
+144
+00:11:43,700 --> 00:11:48,020
+shoulder أو تهلك في plateau أو تهلك في maximum
+
+145
+00:11:48,020 --> 00:11:52,020
+ماتبجعش هي ال global ماتبجعش هي ال global
+
+146
+00:11:56,190 --> 00:12:00,770
+هذا ببساطة اللي هو قليل عمل في ال climbing من
+
+147
+00:12:00,770 --> 00:12:08,950
+ناحية algorithm ك algorithm خطواتها طب
+
+148
+00:12:08,950 --> 00:12:12,970
+احنا لما خدنا ال best strategy لما كانت تصل لنقطة
+
+149
+00:12:12,970 --> 00:12:18,910
+بيكون عندها تفرق تبحر في عندها ال J of H متساوية
+
+150
+00:12:18,910 --> 00:12:24,520
+كانت تختار عملي جدا هدفها في ال A starطب هنا اسمها
+
+151
+00:12:24,520 --> 00:12:30,240
+local، local يعني انطق النظر تبحق قصير، تتطلع بس
+
+152
+00:12:30,240 --> 00:12:34,440
+على، عشان، على الدائرة المباشرة المحيطة يبقى، يعني
+
+153
+00:12:34,440 --> 00:12:36,540
+ال node اللي أنا واقف عليها و ال children اللي
+
+154
+00:12:36,540 --> 00:12:42,080
+بتفرها مني، تمام؟ ما بتقدر تشوف أبعد من هيك، اللي
+
+155
+00:12:42,080 --> 00:12:47,440
+تستكشف إن والله ورا ال plateau هذا، ورا ال plateau
+
+156
+00:12:47,440 --> 00:12:51,380
+هذا، ممكن يكون في node أفضل، فانا أستمر
+
+157
+00:12:55,570 --> 00:13:01,450
+القليل من العمل هو أننا نقف على ال node لل current
+
+158
+00:13:01,450 --> 00:13:05,190
+ثم نقف على ال loop ثم نقف على ال neighbors ثم نقف
+
+159
+00:13:05,190 --> 00:13:09,250
+على ال neighbors ثم نقف على ال neighbors ثم نقف
+
+160
+00:13:09,250 --> 00:13:12,330
+على ال neighbors ثم نقف على ال neighbors ثم نقف
+
+161
+00:13:12,330 --> 00:13:13,210
+على ال neighbors ثم نقف على ال neighbors ثم نقف
+
+162
+00:13:13,210 --> 00:13:17,330
+على ال neighbors ثم نقف على ال neighbors ثم نقف
+
+163
+00:13:17,330 --> 00:13:17,330
+على ال neighbors ثم نقف على ال neighbors ثم نقف
+
+164
+00:13:17,330 --> 00:13:17,330
+على ال neighbors ثم نقف على ال neighbors ثم نقف
+
+165
+00:13:17,330 --> 00:13:17,330
+على ال neighbors ثم نقف على ال neighbors ثم نقف
+
+166
+00:13:17,330 --> 00:13:17,330
+على ال neighbors ثم نقف على ال neighbors ثم نقف
+
+167
+00:13:17,330 --> 00:13:17,330
+على ال neighbors ثم نقف على ال neighbors ثم نقف
+
+168
+00:13:17,330 --> 00:13:17,330
+على ال neighbors ثم نقف على ال neighbors ثم نقف
+
+169
+00:13:17,330 --> 00:13:18,670
+على ال neighbors ثم نقف على ال neighbors ثم نقف
+
+170
+00:13:18,670 --> 00:13:24,250
+على ال neighbors ثم نقفالـ highest value و بنتقل
+
+171
+00:13:24,250 --> 00:13:33,050
+إليها إذا ال value هذا إذا ال number هذا أقل
+
+172
+00:13:33,050 --> 00:13:38,950
+من ال current أقل من ال current إذا هو أعلى واحد
+
+173
+00:13:38,950 --> 00:13:43,110
+فيهم يعني أنا هنا مثلا سبعة و أعلى واحد فيهم كان
+
+174
+00:13:43,110 --> 00:13:49,110
+خمسة إيش معنى ذلك يعني أعلى واحد فيالخيارات
+
+175
+00:13:49,110 --> 00:13:54,970
+المتاحة اللي لسه أقل مني يبقى في
+
+176
+00:13:54,970 --> 00:14:00,570
+إيش تمام؟ ال algorithm مش تمام؟ الروح بيختار نفسها
+
+177
+00:14:00,570 --> 00:14:02,910
+ليش بيختارها إذا كانت أسوأ من اللي أنا و عارف
+
+178
+00:14:02,910 --> 00:14:07,710
+عليه؟ هو تقييم مش معناته أعلى، ان هو أقل، بيختار
+
+179
+00:14:07,710 --> 00:14:10,770
+لأقل اللي بيجربنا إذا ال value تبع ال neighbors
+
+180
+00:14:10,770 --> 00:14:15,410
+أنا اخترت أن أطلعك على ال neighbors و أختارت أفضل
+
+181
+00:14:15,410 --> 00:14:20,330
+واحد فيهمو كان أفضل واحد فيهم أقل مني أنا هنا سبعة
+
+182
+00:14:20,330 --> 00:14:23,610
+بطلع
+
+183
+00:14:23,610 --> 00:14:29,550
+خلاص بنهي مافيش مجال أتحرك بنهي و بقول ان ال ..
+
+184
+00:14:29,550 --> 00:14:33,950
+اللي لا ناجيته هو ال current هذا ال current هذا هو
+
+185
+00:14:33,950 --> 00:14:38,790
+goal ولا مش goal ال algorithm مابخسهاش لأنه هي
+
+186
+00:14:38,790 --> 00:14:45,330
+مابتقدرش تعمل أكتر من ايه صح؟ وإلا إذا مش أجل يبقى
+
+187
+00:14:45,330 --> 00:14:51,580
+إماأقل أو يساوي يا ناسي إذا أقل أو يساوي احتجازك
+
+188
+00:14:51,580 --> 00:14:55,800
+إذا أحسن ال neighbor هذا اللي أحسن افترض ان انا
+
+189
+00:14:55,800 --> 00:15:01,000
+سبعة و الأحسن كانت تسعة ال neighbor هذا اللي تسعة
+
+190
+00:15:01,000 --> 00:15:06,440
+هو اللي بصير current و بستمر بستمر في اللوبي ماشي
+
+191
+00:15:06,440 --> 00:15:12,140
+بخرج من اللوبي إذا كان أفضل واحد في المتاحين أقل
+
+192
+00:15:12,140 --> 00:15:22,140
+أو يساوي من اللي ..من ال current طبعا هذا
+
+193
+00:15:22,140 --> 00:15:27,500
+الكلام فيه عليه عيوب أو عيبه الأساسي اللي هو ال
+
+194
+00:15:27,500 --> 00:15:34,320
+local minima هل تفكر ان هذول ايش local minima هي
+
+195
+00:15:34,320 --> 00:15:38,620
+ال algorithm هتخرج اذا وصلت لها لنغارة هتخرج بس
+
+196
+00:15:38,620 --> 00:15:42,340
+بدون ما تكون وصلت لمن لل global minima او لل
+
+197
+00:15:42,340 --> 00:15:49,220
+global maximumفاحنا الآن بنتطلع على variants أو
+
+198
+00:15:49,220 --> 00:15:53,040
+بدائل أو تغييرات في ال hill climbing algorithm
+
+199
+00:15:53,040 --> 00:15:58,000
+اللي تخليها ربما تخرج من هذه المطابات أو من هذه ال
+
+200
+00:15:58,000 --> 00:16:02,920
+local minima بس بالأول بنتطلع على المثال هذا اللي
+
+201
+00:16:02,920 --> 00:16:11,080
+هو ال eight queens اللغة بهذه اذا حدا مرت عليه و
+
+202
+00:16:11,080 --> 00:16:15,120
+اتخيلها هذا المثال و احنا بنحكي كمان شويةإن انت
+
+203
+00:16:15,120 --> 00:16:17,920
+هنا في اللعبة هذه الهدف طبعا اللعبة هذه ممكن تبقى
+
+204
+00:16:17,920 --> 00:16:22,060
+eight وممكن تبقى four بمعنى ان اللوحة تكون اربع
+
+205
+00:16:22,060 --> 00:16:29,000
+اربع فاربع فقط او
+
+206
+00:16:29,000 --> 00:16:32,520
+تمانية في تمانية او ماعليه دالي الهدف في اللعبة
+
+207
+00:16:32,520 --> 00:16:37,540
+هذه ان انا انحط ال queens هذه بحيث انه مايبقاش في
+
+208
+00:16:37,540 --> 00:16:43,800
+two او more queens مشتركين في افقي او عمودي او
+
+209
+00:16:43,800 --> 00:16:48,420
+دلوقتييعني مثلا هنا هدولة ماشيين على او قاعدين على
+
+210
+00:16:48,420 --> 00:16:56,320
+نفس الأفق صح وهذا مرفوض لازم تتحرك تنتين و يعني
+
+211
+00:16:56,320 --> 00:16:59,680
+هذا مثلا ينجلق هنا وهذا ينجلق في مكان تاني بحسب
+
+212
+00:16:59,680 --> 00:17:03,880
+انه مايضالش على هذا الخط الا واحد كذلك الحالة في
+
+213
+00:17:03,880 --> 00:17:09,360
+الأعمدة هنا في الأعمدة مافيش شي صح انما في الأسطر
+
+214
+00:17:09,360 --> 00:17:13,650
+و بعدين في الدابرة هذا الدابرة المرفوض ماشيهذا
+
+215
+00:17:13,650 --> 00:17:18,370
+عبارة عن أياش solution صح هي على الأعمدة مافيش إلا
+
+216
+00:17:18,370 --> 00:17:21,590
+واحدة وعلى القصد ومافيش إلا واحدة وعلى ال diagonal
+
+217
+00:17:21,590 --> 00:17:26,750
+مافيش .. يعني ال diagonal فيه نعم لو تتخيلها 9 في
+
+218
+00:17:26,750 --> 00:17:31,970
+9 مظبوطش تخليها 9 في 9 مافينا 9 في 9 اه انت تخليها
+
+219
+00:17:31,970 --> 00:17:36,130
+9 في 9 اه عدد اللي هذا عدد ال queens يساوي ال
+
+220
+00:17:36,130 --> 00:17:40,030
+dimensions يساوي ال dimensions فانت ممكن تبقى 4 في
+
+221
+00:17:40,030 --> 00:17:45,710
+4 تبقى 8 في 8 7 في 7المهم الهدف انه ال system لو
+
+222
+00:17:45,710 --> 00:17:49,050
+بدك تعطيله ال system يساوي هذا الكلام مبدأيا هو
+
+223
+00:17:49,050 --> 00:17:53,970
+هبرمى queens randomly بس بحيث ان كل queen تيجي في
+
+224
+00:17:53,970 --> 00:17:59,050
+عمض لحان عشان يضمن ان مافيش شيء بس بعد كهل اللي
+
+225
+00:17:59,050 --> 00:18:05,570
+رماهم في الأعمد المختلفة صدف انه في مشتركين في صدر
+
+226
+00:18:05,570 --> 00:18:06,870
+واحد اللي لأ بده يفحص
+
+227
+00:18:11,720 --> 00:18:15,180
+طبعا في عندنا هنا في الحالة هذه في عندنا إشكالي
+
+228
+00:18:15,180 --> 00:18:19,260
+اللي هو أن هاي مثلا أربعة مشتركين في دررنا و هاي
+
+229
+00:18:19,260 --> 00:18:22,480
+تلاتة مشتركين في دررنا و هاي اتنين مشتركين في
+
+230
+00:18:22,480 --> 00:18:28,440
+دررنا ماشي الان ال system أمامه أنه يحرك هذا state
+
+231
+00:18:28,440 --> 00:18:32,280
+ينتقل منها إلى state أخرى فكل state كل state أخرى
+
+232
+00:18:32,280 --> 00:18:36,200
+ممكن اللي يعملها تنتج عن تنتجت حركة إحدى ال quiz
+
+233
+00:18:36,200 --> 00:18:42,500
+إما إلى مكان واحد من هذه الأماكنفي الأعمدة يعني
+
+234
+00:18:42,500 --> 00:18:47,280
+الكوين هذه ممكن تتقل هنا او هنا او هنا او هنا او
+
+235
+00:18:47,280 --> 00:18:51,760
+هنا او هنا او هنا او هنا صح؟ صح هذا one هي الكوين
+
+236
+00:18:51,760 --> 00:18:54,900
+هذه لحدها الكوين هذه امامها برضه كذلك هال هذا
+
+237
+00:18:54,900 --> 00:18:58,420
+العدد من ال options لأن الأقام هذه هي عمليا
+
+238
+00:18:58,420 --> 00:19:03,340
+التقييم تبع ال move لو هى انتقلت هنا الخمساش هذا
+
+239
+00:19:03,340 --> 00:19:10,320
+بيقولى اكم conflict هيحصي تمام؟ اذا انا نجرتالكوين
+
+240
+00:19:10,320 --> 00:19:15,120
+من هنا لهنا واحد جداش هو الآن عدد ال conflicts في
+
+241
+00:19:15,120 --> 00:19:19,040
+هذه الحالة واحد هاي conflict اتنين تلاتة هاي تلاتة
+
+242
+00:19:19,040 --> 00:19:23,620
+في ال conflicts صح وهاي كمان two conflicts تعاوضين
+
+243
+00:19:23,620 --> 00:19:28,880
+خمسة هاي خمسة و بعدين أيش كمان هاي ستة و بعدين
+
+244
+00:19:28,880 --> 00:19:36,260
+اربعة مصبوط هدول اربعة و اين كمان هاي كمان اتنين و
+
+245
+00:19:36,260 --> 00:19:40,190
+هاي كمان اتنين و هاي كمانففي هذه في المجموعة في
+
+246
+00:19:40,190 --> 00:19:44,330
+تقريبا أظن في هذه اللوحة سبعتاشر conflict المهم
+
+247
+00:19:44,330 --> 00:19:48,190
+أنه لو انتقلت من هنا إلى هنا العدد ال conflicts
+
+248
+00:19:48,190 --> 00:19:52,290
+هيصير خمستاشر لماذا؟ لأن هيته هذا هيروح هذا ال
+
+249
+00:19:52,290 --> 00:19:57,250
+conflict تيجي هذا بداله صح؟ لو انتقلت إلى هنا
+
+250
+00:19:57,250 --> 00:20:00,970
+هيروح هذا ال conflict وهذا هصير مش في conflict
+
+251
+00:20:00,970 --> 00:20:03,790
+فهيجيله هصير أربعتاشر لو انتقلت إلى هنا برضه
+
+252
+00:20:03,790 --> 00:20:06,710
+اربعتاشر لو انتقلت إلى هنا هصير تمطعش لأنه راح
+
+253
+00:20:06,710 --> 00:20:11,050
+conflict و أجي بدالهخمسة conflicts، مظبوط؟
+
+254
+00:20:11,050 --> 00:20:14,890
+فالأرقام هذه عدد ال conflicts إحنا الآن بدنا عدد
+
+255
+00:20:14,890 --> 00:20:18,590
+ال conflicts يزيد ولا يجل؟ يجل يصبح إلى zero ال
+
+256
+00:20:18,590 --> 00:20:23,490
+goal تبعنا هو state أن نصل إلى state عدد ال
+
+257
+00:20:23,490 --> 00:20:28,190
+conflicts فيها صفر يعني أنا ببحث عن local minima،
+
+258
+00:20:28,190 --> 00:20:31,930
+مظبوط؟ local minima ال optimization مقصود بإيما
+
+259
+00:20:31,930 --> 00:20:35,690
+أصولي إلى ال global maximum أو ال global minimum،
+
+260
+00:20:35,690 --> 00:20:39,440
+مظبوط؟ هي ال optimizationفاحنا الأن في اللعبة هذه
+
+261
+00:20:39,440 --> 00:20:45,480
+ال system هييجي يبدأ في لوحة عشوائية و بعدين ايش
+
+262
+00:20:45,480 --> 00:20:50,960
+يفرع منها كل possible moves فمن possible moves عسب
+
+263
+00:20:50,960 --> 00:20:55,900
+عدد اللعبة إذا أما تسعة كل واحدة إلها تمانية
+
+264
+00:20:55,900 --> 00:21:03,760
+خيارات و هم تسعة queens تسعة في تمانيةده معناه عدد
+
+265
+00:21:03,760 --> 00:21:08,160
+من ال children بده يقيم كل واحد من ال children في
+
+266
+00:21:08,160 --> 00:21:10,660
+هذه الهي انا objective function او evaluation
+
+267
+00:21:10,660 --> 00:21:14,020
+function او fitness function سميها ايش ما بدك
+
+268
+00:21:14,020 --> 00:21:19,120
+fitness objective
+
+269
+00:21:19,120 --> 00:21:22,740
+evaluation
+
+270
+00:21:22,740 --> 00:21:26,440
+function
+
+271
+00:21:26,440 --> 00:21:32,410
+هتاخد ال state و بتقول ليالـ state هذه جداش قيمتها
+
+272
+00:21:32,410 --> 00:21:36,630
+جداش عدد ال conflicts اللي فيها الـ state التاني
+
+273
+00:21:36,630 --> 00:21:42,910
+لو أنا نجلت هذا هنا جداش بطلع مظبوط هذا المنظر دمش
+
+274
+00:21:42,910 --> 00:21:47,730
+كل ال states في لوحة واحدة ومعطيني الأقصى انت بقى
+
+275
+00:21:47,730 --> 00:21:52,010
+واضح فالان ال algorithm بنهاشي ال hill climbing
+
+276
+00:21:52,010 --> 00:21:57,530
+algorithm تفرض هذا الفضاء الاحتمالاتو تقيمه و
+
+277
+00:21:57,530 --> 00:22:02,750
+تنتقل إلى ال state اللي أفضل ثم منها إلى الأفضل ثم
+
+278
+00:22:02,750 --> 00:22:05,850
+منها إلى الأفضل الأفضل يعني هبوطا إلى ال zero
+
+279
+00:22:05,850 --> 00:22:11,190
+conflict تمام فهذا الآن انت ممكن تتخيل ال hill
+
+280
+00:22:11,190 --> 00:22:13,670
+climbing algorithm كيف ممكن تشغل على ال problem
+
+281
+00:22:13,670 --> 00:22:16,310
+هذه طيب الآن احنا بقول ان عيش مشكلة ال hill
+
+282
+00:22:16,310 --> 00:22:20,730
+climbing algorithm اللي هي انك تصل إلى state كل
+
+283
+00:22:20,730 --> 00:22:27,520
+المتفرع منها أسوأ منها أسوأ أو يساويالان ايش
+
+284
+00:22:27,520 --> 00:22:33,120
+المخارج الممكنة من هذا الامر ال variance هنا اللي
+
+285
+00:22:33,120 --> 00:22:35,860
+هو انه احنا نعمل تعديلات على ال algorithm بحيث
+
+286
+00:22:35,860 --> 00:22:39,960
+انها ربما تخرج منه ال stochastic hill climbing انه
+
+287
+00:22:39,960 --> 00:22:45,440
+احنا لما تصل الى minima اه ال local minima مش تخرج
+
+288
+00:22:45,440 --> 00:22:51,230
+ايه شو تروح تسويتاخد حلول محددة اي واحد من اللي
+
+289
+00:22:51,230 --> 00:22:56,310
+حواليها و تقفز اليه بغض النظر بغض النظر ان هو أسوأ
+
+290
+00:22:56,310 --> 00:23:02,950
+او لا تمام هذا خروجا من ال .. من ال local minima
+
+291
+00:23:02,950 --> 00:23:07,630
+لأن اذا انا وقفت على ال state ال state هذه كل اللي
+
+292
+00:23:07,630 --> 00:23:14,350
+حواليها أسوأ منها و هي مش goal تمام ماليش مخرج الا
+
+293
+00:23:14,350 --> 00:23:19,470
+ان اغمض عليا و انط نطةعلى أي .. أقفز قفزة على أي
+
+294
+00:23:19,470 --> 00:23:23,830
+location أخر ربما هذه ال location ألاقي حوالين منه
+
+295
+00:23:23,830 --> 00:23:31,920
+steps درجات تدرجني لفوق باسم أختار أفضل الأسوأأفضل
+
+296
+00:23:31,920 --> 00:23:37,480
+أسوأ مانا برضه أفضل أسوأ هذا ما هو كونه هو أفضل
+
+297
+00:23:37,480 --> 00:23:42,220
+أسوأ هذا لا يعني أنه مؤدي إلى الأفضل يعني أنا
+
+298
+00:23:42,220 --> 00:23:46,740
+مابعرفش ما ممكن أفضل أسوأ أفضل أسوأ زي اللي أنا
+
+299
+00:23:46,740 --> 00:23:50,920
+واقف عليها يبقى برضه اللي حواليه كلهم يعني مافي ..
+
+300
+00:23:50,920 --> 00:23:54,860
+مافي أفضلية أن هو أفضل أسوأ ولا أسوأ أسوأ كلهم
+
+301
+00:23:54,860 --> 00:24:00,790
+بالآخر بالنسبة إيه ديالأمر blind بالنسبالي ضبابي
+
+302
+00:24:00,790 --> 00:24:04,350
+مش عارف ايوة فال stochastic هنا probabilistic
+
+303
+00:24:04,350 --> 00:24:08,850
+probability باخد عشوائي ان انا على ال probability
+
+304
+00:24:08,850 --> 00:24:15,470
+باخد عشوائي اي واحد تمام ال first
+
+305
+00:24:15,470 --> 00:24:24,950
+choice hill climbing انه انا اضلني اجرب في اللي
+
+306
+00:24:24,950 --> 00:24:32,690
+حوليالحد ما انا اخد اول
+
+307
+00:24:32,690 --> 00:24:47,790
+افضل واحد لحد
+
+308
+00:24:47,790 --> 00:24:53,210
+ما انا اخد اول افضل واحد لحد ما انا اخد اول افضل
+
+309
+00:24:53,210 --> 00:25:00,480
+واحدfirst choice بمعنى أنه أفضل أخدهم عشوائيا ده
+
+310
+00:25:00,480 --> 00:25:11,900
+هتتملأجي واحد أفضل من اللي معاه التالت
+
+311
+00:25:11,900 --> 00:25:16,380
+الخيار التالت أنه أنا أبدأ بداية جديدة تماما
+
+312
+00:25:16,380 --> 00:25:24,140
+random restart احنا بيكون بدأنا من random state
+
+313
+00:25:24,920 --> 00:25:28,980
+اللي هي start state ومشينا وصلنا لل local minima
+
+314
+00:25:28,980 --> 00:25:34,640
+وقفنا مش عارفين نكمل خلاص بنسي هذي و ببدأ بداية
+
+315
+00:25:34,640 --> 00:25:43,880
+جديدة بداية جديدة ب start state عشوائية جديدة
+
+316
+00:25:43,880 --> 00:25:50,680
+تمام
+
+317
+00:25:50,680 --> 00:25:56,220
+فاحنا الآن عملياصار عندنا فكرة عن ال hill climbing
+
+318
+00:25:56,220 --> 00:26:03,780
+وصار عندنا فكرة عن اللي هو البدائل المطوحة لإخراج
+
+319
+00:26:03,780 --> 00:26:08,800
+ال algorithm من ورطلة اللي هو ال local minima تلت
+
+320
+00:26:08,800 --> 00:26:12,780
+بدائل هدولة اما ال stochastic hill climbing يعني
+
+321
+00:26:12,780 --> 00:26:18,060
+ان اخد random حتى لو كان سيئالأولى هي ان انا
+
+322
+00:26:18,060 --> 00:26:23,740
+بالاصل لما بانتقل بجرب باطلع على الاطفال واحد واحد
+
+323
+00:26:23,740 --> 00:26:31,960
+و باخد الأفضل random و الخيار التالت انه اذا لما
+
+324
+00:26:31,960 --> 00:26:36,400
+ال algorithm تجع في local minima اللي هو انه state
+
+325
+00:26:36,400 --> 00:26:40,080
+مش goal و كل اللي حوالها أسوأ منها بعمل restart
+
+326
+00:26:40,080 --> 00:26:44,160
+لكل ال algorithm من جديد و ببدأ ب random
+
+327
+00:26:48,140 --> 00:26:52,480
+الان احنا في معانا دوبك خمس دقايق نبدأ فيهم و نحكي
+
+328
+00:26:52,480 --> 00:26:56,060
+فيهم على algorithm اخرى all together مختلفة اللي
+
+329
+00:26:56,060 --> 00:26:58,500
+هي simulated learning
+
+330
+00:27:02,230 --> 00:27:05,690
+بيظل معانا وجدت بنكمل بنحكي في الـ Local Beam
+
+331
+00:27:05,690 --> 00:27:09,730
+Algorithm ال simulated annealing مبساطة شديدة ان
+
+332
+00:27:09,730 --> 00:27:14,830
+احنا فيها خصائص بعض خصائص ال hair climbing ان احنا
+
+333
+00:27:14,830 --> 00:27:21,970
+بالاصل بنعمل random selection لواحد من ال
+
+334
+00:27:21,970 --> 00:27:23,850
+successors
+
+335
+00:27:28,960 --> 00:27:32,580
+وبذاك الجلوب هذه Randomly select successor of
+
+336
+00:27:32,580 --> 00:27:36,740
+current هاي ال current ويلها عدة successors نختار
+
+337
+00:27:36,740 --> 00:27:42,540
+واحدة منهم at random ونسميه هو next ال next هذا
+
+338
+00:27:42,540 --> 00:27:45,900
+بنشوف
+
+339
+00:27:45,900 --> 00:27:50,560
+هل هو أحسن و لا أسوأ من هذا عشوائي نحن اختارناه
+
+340
+00:27:50,560 --> 00:27:55,680
+نشوف هو أحسن و لا أسوأ المفروض إذا هو أسوأ أنا
+
+341
+00:27:55,680 --> 00:28:04,980
+ماتطلعش عليهالمفروض بس أخده إذا هو أفضل دلتا
+
+342
+00:28:04,980 --> 00:28:08,900
+E هذه هي عبارة عن الفرق ما بين ال next و ما بين ال
+
+343
+00:28:08,900 --> 00:28:11,900
+current next نقص current إذا next أكبر من current
+
+344
+00:28:11,900 --> 00:28:17,880
+تتجه دلتا E هذه موجة بأكبر من ال zero ففي هذه
+
+345
+00:28:17,880 --> 00:28:24,560
+الحالة إذا دلتا E أكبر من zero على طول بخل ال next
+
+346
+00:28:24,560 --> 00:28:29,110
+هو ال current بنتقل إليهطيب إذا مش أقل المفروض
+
+347
+00:28:29,110 --> 00:28:36,390
+أقنشه لأ بقنشوش ممكن أخليه هو ال current بناء على
+
+348
+00:28:36,390 --> 00:28:43,850
+probability probability احتمالي تمام ال E to delta
+
+349
+00:28:43,850 --> 00:28:47,950
+ال
+
+350
+00:28:47,950 --> 00:28:53,750
+exponential مرفوعة ل delta E اللي هو الفرق على T T
+
+351
+00:28:53,750 --> 00:29:02,740
+هنا capital هي عبارة عنقيمة بتبدأ وبتتناقص تبدأ
+
+352
+00:29:02,740 --> 00:29:07,740
+عالية وبتتناقص مع
+
+353
+00:29:07,740 --> 00:29:14,360
+الزمن او مع ال iterations يعني في ال iteration
+
+354
+00:29:14,360 --> 00:29:17,440
+الأولى تبقى T عالية اللي بعدها .. اللي بعدها ..
+
+355
+00:29:17,440 --> 00:29:22,180
+اللي بعدها .. T بتتناقص واضح ال plot هذا ال plot
+
+356
+00:29:22,180 --> 00:29:27,100
+هو يوثل اللي قلتلكم بين T كمتل وبين I هنا Iش ال
+
+357
+00:29:27,100 --> 00:29:27,540
+iterations
+
+358
+00:29:30,230 --> 00:29:39,050
+تسمول تسمول تسمول تسمول تسمول
+
+359
+00:29:39,050 --> 00:29:39,330
+تسمول تسمول تسمول تسمول تسمول تسمول تسمول تسمول
+
+360
+00:29:39,330 --> 00:29:44,210
+تسمول تسمول تسمول تسمول تسمول تسمول تسمول تسمول
+
+361
+00:29:44,210 --> 00:29:44,490
+تسمول تسمول تسمول تسمول تسمول تسمول تسمول تسمول
+
+362
+00:29:44,490 --> 00:29:44,870
+تسمول تسمول تسمول تسمول تسمول تسمول تسمول تسمول
+
+363
+00:29:44,870 --> 00:29:48,370
+تسمول تسمول تسمول تسمول تسمول تسمول تسمول تسمول
+
+364
+00:29:48,370 --> 00:29:48,490
+تسمول تسمول تسمول تسمول تسمول تسمول تسمول تسمول
+
+365
+00:29:48,490 --> 00:29:48,490
+تسمول تسمول تسمول تسمول تسمول تسمول تسمول تسمول
+
+366
+00:29:48,490 --> 00:29:48,490
+تسمول تسمول تسمول تسمول تسمول تسمول تسمول تسمول
+
+367
+00:29:48,490 --> 00:29:55,290
+تسمول تسمول تسمول تسمول
+
+368
+00:29:55,290 --> 00:30:05,800
+تسمول تسممبدأ يكبر صح لما T تتناقص كلما كبر ال E
+
+369
+00:30:05,800 --> 00:30:09,540
+هذا او
+
+370
+00:30:09,540 --> 00:30:14,600
+كل ال function ال exponential function لما انا
+
+371
+00:30:14,600 --> 00:30:22,800
+برفعها أس كلما بكبر الأس هذا بيصغر تمام فايش بيصير
+
+372
+00:30:22,800 --> 00:30:28,850
+ال probability بتجللـ probability مع الزمن مع عدد
+
+373
+00:30:28,850 --> 00:30:33,070
+ال iterations بيبدأ هذا النقطة ينخفض فإذا انخفضت
+
+374
+00:30:33,070 --> 00:30:37,230
+ال probability بيصير الاحتمال ان انا اخدها على
+
+375
+00:30:37,230 --> 00:30:41,910
+الرغم من انها سيئة بيصير اضعف انما في أول ال
+
+376
+00:30:41,910 --> 00:30:45,850
+algorithm في أول ال iterations تجاوزت جدا ان انا
+
+377
+00:30:45,850 --> 00:30:53,430
+ممكن اخد ال neighbor انتقل
+
+378
+00:30:53,430 --> 00:30:59,150
+اليها على الرغم من انها عايش سيئةOkay احنا ليش
+
+379
+00:30:59,150 --> 00:31:03,870
+بنقول هذا ال condition هذا انا بدي اخد ال neighbor
+
+380
+00:31:03,870 --> 00:31:08,110
+على الرغم من انها سيئة على الرغم من انه اقل من
+
+381
+00:31:08,110 --> 00:31:11,810
+اللي انا واجه عليه هذا الأمر راجع لاحتمالية و
+
+382
+00:31:11,810 --> 00:31:15,910
+الاحتمالية بتتنقص مع الزمن بتبقى عالية في بداية ال
+
+383
+00:31:15,910 --> 00:31:21,790
+iterations و بتنخفض مع الزمن يبقى انا في بداية ال
+
+384
+00:31:21,790 --> 00:31:26,450
+algorithm ممكن و انا هنا مثلا start انا قيمتها 7
+
+385
+00:31:26,990 --> 00:31:32,090
+وعندى اخد random child اللى هو مين ال next وعشان
+
+386
+00:31:32,090 --> 00:31:36,790
+اطلع عن ال next انا جيه خمسة تمام المفروض مانتقلش
+
+387
+00:31:36,790 --> 00:31:41,630
+اليه لكن انا لانى لسه في بداية الشغل وفي بداية
+
+388
+00:31:41,630 --> 00:31:47,290
+الشغل ال T كبيرة كبيرة فهذا المقام كبير وبالتالي
+
+389
+00:31:47,290 --> 00:31:51,070
+المقدار هذا صغير وبالتالي هذا بيبقى عالى ال
+
+390
+00:31:51,070 --> 00:31:57,650
+exponential عالى فممكن يبقى للمحتمالية 90%تمام
+
+391
+00:31:57,650 --> 00:32:04,650
+فاتم هذا الإجراء اللي هو أنت في ال اليل لكن جدّام
+
+392
+00:32:04,650 --> 00:32:08,750
+الاحتمالية تبقى ضعفة تصير ال 9% ممكن تصل ل 10% أو
+
+393
+00:32:08,750 --> 00:32:14,710
+5% واضح فهذا ال simulated annealing بيسمح
+
+394
+00:32:14,710 --> 00:32:20,290
+بالانتقال إلى نود سيئة تمام أنه أنا مانديش أستمر
+
+395
+00:32:20,290 --> 00:32:25,690
+في الصعود ممكن أصعد أصعد و بعد ذلك أنزل هذا الصعود
+
+396
+00:32:25,690 --> 00:32:31,380
+و النزوليحسن أداء ال algorithm في الوصول إلى ال
+
+397
+00:32:31,380 --> 00:32:38,860
+global maximum فكله بيتمد على هذا المقدار اللي
+
+398
+00:32:38,860 --> 00:32:45,460
+بيتمد على الزمن هذا ال schedule هو فاكر فيها كإنها
+
+399
+00:32:45,460 --> 00:32:51,740
+عبارة عن array ال array هذه فيها أرقام الأرقام هذه
+
+400
+00:32:51,740 --> 00:32:59,840
+بتتناقص95 كانت تتنقص فانا على iteration T بتساوي
+
+401
+00:32:59,840 --> 00:33:15,720
+one هاخد رقم كبير على T هي هنا هي T هي T
+
+402
+00:33:15,720 --> 00:33:21,120
+وهي schedule of T T صغيرة بياخد رقم كبير T كل ما
+
+403
+00:33:21,120 --> 00:33:26,380
+تكبر T small بيصغر منالـ Schedule الـ Value تبعها
+
+404
+00:33:26,380 --> 00:33:31,020
+طبعا هنا التناقص ممكن يبقى خطي و ممكن يبقى التناقص
+
+405
+00:33:31,020 --> 00:33:37,200
+برضه كمان عاشر curve مش ضروري يبقى خطي المهم انت
+
+406
+00:33:37,200 --> 00:33:42,460
+تخيله عبارة عن قيم تتناقص و تناقصها بيضعف
+
+407
+00:33:42,460 --> 00:33:49,520
+الاحتمالية صح الاحتمالية ان انا اخد note اسوأ من
+
+408
+00:33:49,520 --> 00:33:52,920
+اللي انا فيهاالمفروض ان انا مااخدش بس هذا وارد و
+
+409
+00:33:52,920 --> 00:33:56,920
+احتماليته بتتناقص في الأول بتبقى عالية في مدينة
+
+410
+00:33:56,920 --> 00:34:01,640
+الشغل و بتتناقص جدا تمام؟ بنكمل المحاضرة الجاية و
+
+411
+00:34:01,640 --> 00:34:04,460
+بنحكي في ال local beam search
+
diff --git a/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/w5_g1XJUFrI_raw.json b/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/w5_g1XJUFrI_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..ff0d2d276922f188fbb4d20c194eb5d5a2ac7422
--- /dev/null
+++ b/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/w5_g1XJUFrI_raw.json
@@ -0,0 +1 @@
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" إلى", "probability": 0.51611328125}, {"start": 443.73, "end": 444.77, "word": " R6", "probability": 0.97607421875}, {"start": 444.77, "end": 445.15, "word": " لأن", "probability": 0.759521484375}, {"start": 445.15, "end": 445.45, "word": " ليش", "probability": 0.841064453125}, {"start": 445.45, "end": 445.93, "word": " ستة", "probability": 0.8008626302083334}, {"start": 445.93, "end": 447.29, "word": " rules؟", "probability": 0.5809326171875}, {"start": 447.29, "end": 447.59, "word": " ليش", "probability": 0.91650390625}, {"start": 447.59, "end": 447.73, "word": " مش", "probability": 0.955078125}, {"start": 447.73, "end": 448.25, "word": " تمانية؟", "probability": 0.858642578125}, {"start": 448.25, "end": 448.41, "word": " ليش", "probability": 0.9609375}, {"start": 448.41, "end": 448.59, "word": " مش", "probability": 0.9921875}, {"start": 448.59, "end": 449.41, "word": " عشرة؟", "probability": 0.9542236328125}, {"start": 449.41, "end": 449.71, "word": " خلص", "probability": 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ليش هذا X1 مابوزهش ل B1 وB2 وB3 لأن هدولة مش تبعونه يعني احنا اقول مثلا هذا اللي هو الطول طول الشخص وهذا وزنه الأوزان", "tokens": [28820, 36764, 24401, 3660, 39894, 47283, 3215, 25062, 46152, 16712, 16758, 3615, 11296, 9154, 3714, 9957, 9154, 11778, 47341, 3660, 16472, 39237, 16606, 9673, 2655, 17082, 13546, 30731, 2423, 6352, 6055, 3555, 3615, 11536, 3224, 23032, 3555, 3615, 995, 32239, 8592, 23758, 1783, 16, 3714, 16758, 2407, 11622, 3224, 8592, 5296, 363, 16, 4032, 33, 17, 4032, 33, 18, 5296, 33456, 8032, 3215, 12610, 3660, 37893, 6055, 3555, 3615, 11536, 3224, 37495, 22653, 1975, 5016, 8315, 1975, 39648, 50113, 15040, 23758, 13672, 1829, 31439, 41950, 12610, 23032, 12610, 25124, 9778, 9381, 37037, 15730, 4032, 11622, 1863, 3224, 2423, 10721, 2407, 11622, 7649], "avg_logprob": -0.2841322844468274, "compression_ratio": 1.6826923076923077, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 483.67, "end": 483.93, "word": "كل", "probability": 0.8603515625}, {"start": 483.93, 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باخد", "probability": 0.9375}, {"start": 1062.6, "end": 1063.08, "word": " progressive", "probability": 0.2958984375}, {"start": 1063.08, "end": 1063.3, "word": " or", "probability": 0.9296875}, {"start": 1063.3, "end": 1063.42, "word": " اللي", "probability": 0.865234375}, {"start": 1063.42, "end": 1063.58, "word": " هو", "probability": 0.98779296875}, {"start": 1063.58, "end": 1064.0, "word": " باخد", "probability": 0.92626953125}, {"start": 1064.0, "end": 1064.74, "word": " مجموحهم", "probability": 0.876220703125}, {"start": 1064.74, "end": 1065.24, "word": " ناقص", "probability": 0.980712890625}, {"start": 1065.24, "end": 1066.0, "word": " حاصل", "probability": 0.91943359375}, {"start": 1066.0, "end": 1066.54, "word": " ضربهم", "probability": 0.9873046875}, {"start": 1066.54, "end": 1067.68, "word": " الاتنين", "probability": 0.83709716796875}], "temperature": 1.0}, {"id": 37, "seek": 109823, "start": 1069.77, "end": 1098.23, "text": "Okay ال end بعد هيك هذا الكلام ال output بس دكتور مش بالغالب أساسا ايش اسمه ال disjunction اللي هو ال or اللي بيشمل كل اللي بيشمل يعني هو true for all ال end يعني لو انت كان عندك true true تمام true or true true or اي حاجة true تمام او اي اشي true هو فعليا true صح نعم و هنا", "tokens": [8297, 2423, 917, 39182, 39896, 4117, 23758, 2423, 28820, 10943, 2423, 5598, 4724, 3794, 11778, 4117, 2655, 13063, 37893, 20666, 17082, 6027, 3555, 5551, 3794, 32277, 995, 1975, 1829, 8592, 24525, 2304, 3224, 2423, 717, 10010, 882, 13672, 1829, 31439, 2423, 420, 13672, 1829, 4724, 1829, 8592, 42213, 28242, 13672, 1829, 4724, 1829, 8592, 42213, 37495, 22653, 31439, 2074, 337, 439, 2423, 917, 37495, 22653, 45164, 16472, 2655, 25961, 43242, 4117, 2074, 2074, 46811, 10943, 2074, 420, 2074, 2074, 420, 1975, 1829, 11331, 26108, 3660, 2074, 46811, 10943, 1975, 2407, 1975, 1829, 1975, 8592, 1829, 2074, 31439, 6156, 3615, 20292, 995, 2074, 20328, 5016, 8717, 25957, 4032, 34105], "avg_logprob": -0.20470183650288012, "compression_ratio": 1.8149779735682818, 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0.9423828125}, {"start": 1086.31, "end": 1086.49, "word": " انت", "probability": 0.73388671875}, {"start": 1086.49, "end": 1086.61, "word": " كان", "probability": 0.984375}, {"start": 1086.61, "end": 1086.81, "word": " عندك", "probability": 0.99560546875}, {"start": 1086.81, "end": 1086.99, "word": " true", "probability": 0.98779296875}, {"start": 1086.99, "end": 1087.31, "word": " true", "probability": 0.98095703125}, {"start": 1087.31, "end": 1088.31, "word": " تمام", "probability": 0.854248046875}, {"start": 1088.31, "end": 1089.33, "word": " true", "probability": 0.8994140625}, {"start": 1089.33, "end": 1089.81, "word": " or", "probability": 0.97265625}, {"start": 1089.81, "end": 1090.21, "word": " true", "probability": 0.9677734375}, {"start": 1090.21, "end": 1090.75, "word": " true", "probability": 0.188720703125}, {"start": 1090.75, "end": 1091.11, "word": " or", "probability": 0.837890625}, {"start": 1091.11, "end": 1091.31, "word": " اي", "probability": 0.78466796875}, {"start": 1091.31, "end": 1091.81, "word": " حاجة", "probability": 0.9641927083333334}, {"start": 1091.81, "end": 1091.97, "word": " true", "probability": 0.9501953125}, {"start": 1091.97, "end": 1093.15, "word": " تمام", "probability": 0.7276611328125}, {"start": 1093.15, "end": 1093.73, "word": " او", "probability": 0.876220703125}, {"start": 1093.73, "end": 1093.97, "word": " اي", "probability": 0.8203125}, {"start": 1093.97, "end": 1094.25, "word": " اشي", "probability": 0.8214518229166666}, {"start": 1094.25, "end": 1094.51, "word": " true", "probability": 0.984375}, {"start": 1094.51, "end": 1094.83, "word": " هو", "probability": 0.88330078125}, {"start": 1094.83, "end": 1095.33, "word": " فعليا", "probability": 0.910400390625}, {"start": 1095.33, "end": 1095.67, "word": " true", "probability": 0.98583984375}, {"start": 1095.67, "end": 1096.51, "word": " صح", "probability": 0.982177734375}, {"start": 1096.51, "end": 1097.61, "word": " نعم", "probability": 0.7196044921875}, {"start": 1097.61, "end": 1097.91, "word": " و", "probability": 0.76171875}, {"start": 1097.91, "end": 1098.23, "word": " هنا", "probability": 0.9697265625}], "temperature": 1.0}, {"id": 38, "seek": 112811, "start": 1098.98, "end": 1128.12, "text": "هنا انا شايف ان انت ال intersection اللي بينهم انت بطلت أساسا ماخده في عينك اعتباره يعني انت ماخد ال sets مخصص ال intersection تبعه يعني عمليا طلع كده انا ماخدتش ال union نفسي يعني انت تخيل ان انا عندي لحظة شوية بس لحظة شوية طلع اتخيل ان انا عندي two values ال two values هدولة واحد منهم انا هنا", "tokens": [3224, 8315, 1975, 8315, 13412, 995, 33911, 16472, 16472, 2655, 2423, 15236, 13672, 1829, 49374, 16095, 16472, 2655, 4724, 9566, 1211, 2655, 5551, 3794, 32277, 995, 3714, 47283, 3215, 3224, 8978, 6225, 9957, 4117, 1975, 34268, 3555, 9640, 3224, 37495, 22653, 16472, 2655, 3714, 47283, 3215, 2423, 6352, 3714, 9778, 9381, 9381, 2423, 15236, 6055, 3555, 3615, 3224, 37495, 22653, 6225, 2304, 20292, 995, 23032, 1211, 3615, 9122, 3215, 3224, 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ال", "probability": 0.7216796875}, {"start": 1100.56, "end": 1101.04, "word": " intersection", "probability": 0.416748046875}, {"start": 1101.04, "end": 1101.34, "word": " اللي", "probability": 0.8994140625}, {"start": 1101.34, "end": 1101.8, "word": " بينهم", "probability": 0.985107421875}, {"start": 1101.8, "end": 1102.32, "word": " انت", "probability": 0.78173828125}, {"start": 1102.32, "end": 1103.56, "word": " بطلت", "probability": 0.8468017578125}, {"start": 1103.56, "end": 1104.02, "word": " أساسا", "probability": 0.79718017578125}, {"start": 1104.02, "end": 1104.34, "word": " ماخده", "probability": 0.79827880859375}, {"start": 1104.34, "end": 1104.4, "word": " في", "probability": 0.9140625}, {"start": 1104.4, "end": 1104.56, "word": " عينك", "probability": 0.9313151041666666}, {"start": 1104.56, "end": 1105.22, "word": " اعتباره", "probability": 0.8279296875}, {"start": 1105.22, "end": 1105.8, "word": " يعني", "probability": 0.897216796875}, {"start": 1105.8, "end": 1105.96, 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1621.81, "end": 1622.33, "word": " عنها", "probability": 0.994384765625}, {"start": 1622.33, "end": 1622.77, "word": " ب", "probability": 0.8603515625}, {"start": 1622.77, "end": 1624.27, "word": " formulas", "probability": 0.438232421875}, {"start": 1624.27, "end": 1624.97, "word": " يعني", "probability": 0.688720703125}, {"start": 1624.97, "end": 1625.31, "word": " مثلا", "probability": 0.968017578125}, {"start": 1625.31, "end": 1625.69, "word": " y", "probability": 0.472900390625}, {"start": 1625.69, "end": 1627.91, "word": " yi", "probability": 0.337646484375}], "temperature": 1.0}, {"id": 58, "seek": 165596, "start": 1628.68, "end": 1655.96, "text": "بتعطي 0 إذا كان ال value اللي دخل عليها أقل من أو تساوي ال a نقص بي على اتنين ايش ال a و ال b على اتنين لما يكون عندي مثلة زي هيكة مثلة زي هذا وين هو ال center تبعه هذا a و بي هي عبارة عن ال width تبعه", "tokens": [3555, 2655, 3615, 9566, 1829, 1958, 11933, 15730, 25961, 2423, 2158, 13672, 1829, 11778, 9778, 1211, 25894, 11296, 5551, 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{"start": 1642.02, "end": 1642.28, "word": " عندي", "probability": 0.810302734375}, {"start": 1642.28, "end": 1642.7, "word": " مثلة", "probability": 0.656005859375}, {"start": 1642.7, "end": 1642.96, "word": " زي", "probability": 0.698486328125}, {"start": 1642.96, "end": 1643.52, "word": " هيكة", "probability": 0.5277506510416666}, {"start": 1643.52, "end": 1644.8, "word": " مثلة", "probability": 0.95556640625}, {"start": 1644.8, "end": 1645.02, "word": " زي", "probability": 0.976318359375}, {"start": 1645.02, "end": 1645.32, "word": " هذا", "probability": 0.71484375}, {"start": 1645.32, "end": 1647.32, "word": " وين", "probability": 0.8544921875}, {"start": 1647.32, "end": 1647.74, "word": " هو", "probability": 0.97412109375}, {"start": 1647.74, "end": 1648.28, "word": " ال", "probability": 0.93017578125}, {"start": 1648.28, "end": 1648.6, "word": " center", "probability": 0.830078125}, {"start": 1648.6, "end": 1649.06, "word": " تبعه", "probability": 0.8509521484375}, {"start": 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هذا ال set اللي يبقى ال zero والعكس لو أكبر من نفس القيمة إذا وقع في المص يبقى انتمائه يعتمد على وين يتقاطع معه", "tokens": [3555, 1863, 16606, 15844, 23758, 2423, 28820, 10943, 11933, 15730, 25961, 2423, 2158, 13672, 1829, 11778, 9778, 1211, 5551, 4587, 1211, 9154, 23758, 37495, 22653, 14739, 3224, 10874, 47302, 34105, 37495, 22653, 14739, 3224, 20193, 7251, 29399, 2304, 1829, 20666, 2304, 25720, 30731, 23758, 2423, 992, 13672, 1829, 7251, 3555, 4587, 7578, 2423, 4018, 16070, 3615, 4117, 3794, 45164, 5551, 4117, 26890, 9154, 8717, 36178, 25062, 32640, 3660, 11933, 15730, 4032, 4587, 3615, 8978, 9673, 9381, 7251, 3555, 4587, 7578, 16472, 39237, 16373, 3224, 7251, 34268, 2304, 3215, 15844, 4032, 9957, 7251, 2655, 4587, 41193, 3615, 20449, 3224], "avg_logprob": -0.31660352451632723, "compression_ratio": 1.78743961352657, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1660.62, "end": 1661.54, "word": "بناء", "probability": 0.613037109375}, {"start": 1661.54, "end": 1661.7, 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يعني", "probability": 0.723388671875}, {"start": 1669.72, "end": 1670.38, "word": " أنه", "probability": 0.6038818359375}, {"start": 1670.38, "end": 1670.7, "word": " جاي", "probability": 0.5423583984375}, {"start": 1670.7, "end": 1670.96, "word": " هنا", "probability": 0.97021484375}, {"start": 1670.96, "end": 1671.28, "word": " يعني", "probability": 0.54766845703125}, {"start": 1671.28, "end": 1672.88, "word": " أنه", "probability": 0.6849365234375}, {"start": 1672.88, "end": 1673.02, "word": " لا", "probability": 0.6357421875}, {"start": 1673.02, "end": 1673.52, "word": " ينتمي", "probability": 0.87646484375}, {"start": 1673.52, "end": 1673.96, "word": " بالمرة", "probability": 0.7916666666666666}, {"start": 1673.96, "end": 1674.42, "word": " إلى", "probability": 0.80419921875}, {"start": 1674.42, "end": 1675.04, "word": " هذا", "probability": 0.79345703125}, {"start": 1675.04, "end": 1675.16, "word": " ال", "probability": 0.67626953125}, {"start": 1675.16, "end": 1675.36, "word": " set", "probability": 0.732421875}, {"start": 1675.36, "end": 1675.5, "word": " اللي", "probability": 0.84375}, {"start": 1675.5, "end": 1675.64, "word": " يبقى", "probability": 0.72662353515625}, {"start": 1675.64, "end": 1675.8, "word": " ال", "probability": 0.420654296875}, {"start": 1675.8, "end": 1676.06, "word": " zero", "probability": 0.4091796875}, {"start": 1676.06, "end": 1677.28, "word": " والعكس", "probability": 0.8507080078125}, {"start": 1677.28, "end": 1677.76, "word": " لو", "probability": 0.4951171875}, {"start": 1677.76, "end": 1678.72, "word": " أكبر", "probability": 0.86083984375}, {"start": 1678.72, "end": 1680.3, "word": " من", "probability": 0.493896484375}, {"start": 1680.3, "end": 1680.9, "word": " نفس", "probability": 0.98876953125}, {"start": 1680.9, "end": 1681.42, "word": " القيمة", "probability": 0.9571940104166666}, {"start": 1681.42, "end": 1682.7, "word": " إذا", "probability": 0.71630859375}, {"start": 1682.7, "end": 1683.16, "word": " وقع", 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"end": 2230.84, "word": " من", "probability": 0.54052734375}, {"start": 2230.84, "end": 2230.88, "word": " ال", "probability": 0.96240234375}, {"start": 2230.88, "end": 2231.04, "word": " rules", "probability": 0.8740234375}, {"start": 2231.04, "end": 2231.18, "word": " و", "probability": 0.63330078125}, {"start": 2231.18, "end": 2231.52, "word": " تشوف", "probability": 0.9943033854166666}, {"start": 2231.52, "end": 2231.74, "word": " هذه", "probability": 0.59375}, {"start": 2231.74, "end": 2231.86, "word": " ال", "probability": 0.97802734375}, {"start": 2231.86, "end": 2232.08, "word": " rules", "probability": 0.884765625}, {"start": 2232.08, "end": 2232.46, "word": " هذه", "probability": 0.428955078125}, {"start": 2232.46, "end": 2233.44, "word": " هتثبت", "probability": 0.91806640625}, {"start": 2233.44, "end": 2233.72, "word": " او", "probability": 0.47247314453125}, {"start": 2233.72, "end": 2234.58, "word": " لا", "probability": 0.525390625}, {"start": 2234.58, "end": 2235.68, 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{"start": 2240.42, "end": 2241.28, "word": " انت", "probability": 0.91552734375}, {"start": 2241.28, "end": 2241.68, "word": " كل", "probability": 0.6640625}, {"start": 2241.68, "end": 2242.26, "word": " فترة", "probability": 0.9957682291666666}, {"start": 2242.26, "end": 2242.72, "word": " معينة", "probability": 0.9874674479166666}, {"start": 2242.72, "end": 2243.0, "word": " بتكون", "probability": 0.749755859375}, {"start": 2243.0, "end": 2243.44, "word": " استجد", "probability": 0.939453125}, {"start": 2243.44, "end": 2243.82, "word": " عندك", "probability": 0.6767578125}, {"start": 2243.82, "end": 2244.1, "word": " data", "probability": 0.95361328125}, {"start": 2244.1, "end": 2244.66, "word": " جديدة", "probability": 0.97119140625}, {"start": 2244.66, "end": 2245.42, "word": " فلازم", "probability": 0.9122314453125}, {"start": 2245.42, "end": 2245.54, "word": " ال", "probability": 0.87060546875}, {"start": 2245.54, "end": 2245.74, "word": " data", "probability": 0.9921875}, {"start": 2245.74, "end": 2246.06, "word": " هذه", "probability": 0.720703125}, {"start": 2246.06, "end": 2247.22, "word": " تدخلها", "probability": 0.84951171875}, {"start": 2247.22, "end": 2248.32, "word": " علينتك", "probability": 0.608428955078125}, {"start": 2248.32, "end": 2248.92, "word": " عشان", "probability": 0.816162109375}, {"start": 2248.92, "end": 2249.62, "word": " تستفيد", "probability": 0.986083984375}, {"start": 2249.62, "end": 2249.86, "word": " منها", "probability": 0.994384765625}, {"start": 2249.86, "end": 2250.0, "word": " في", "probability": 0.91015625}, {"start": 2250.0, "end": 2250.28, "word": " ال", "probability": 0.58984375}, {"start": 2250.28, "end": 2250.48, "word": " ..", "probability": 0.783203125}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2250.803, "duration_after_vad": 2150.1149999999952}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/wgYSObCO2Ek.srt b/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/wgYSObCO2Ek.srt
new file mode 100644
index 0000000000000000000000000000000000000000..0c343fc9d09c10384b8adc1e74464e9226e6ef6f
--- /dev/null
+++ b/PL9fwy3NUQKwY229s7FFto_DG4Gk-imNVi/wgYSObCO2Ek.srt
@@ -0,0 +1,1609 @@
+1
+00:00:20,910 --> 00:00:24,530
+بسم الله الرحمن الرحيم اليوم إن شاء الله بدنا نكمل
+
+2
+00:00:24,530 --> 00:00:27,810
+موضوع الـ adversarial search موضوع الـ adversarial
+
+3
+00:00:27,810 --> 00:00:32,250
+search اللي بدينا فيه المحاضرة الماضية كان .. كنا
+
+4
+00:00:32,250 --> 00:00:35,910
+.. حكينا فيه اللي هو الـ minimax procedure أو الـ
+
+5
+00:00:35,910 --> 00:00:41,370
+minimax algorithm وبرجع سريعًا على المثال اللي
+
+6
+00:00:41,370 --> 00:00:46,750
+طلعنا عليه المحاضرة اللي فاتت، المثال كان عن كيف لو
+
+7
+00:00:46,750 --> 00:00:52,350
+احنا اللعبة اللي تبعت الـ Tic-Tac-Toe اللي هي كل
+
+8
+00:00:52,350 --> 00:00:59,150
+لاعب بيحط من عنده قطعة، والهدف أن اللاعب ينزم
+
+9
+00:00:59,150 --> 00:01:03,990
+اللاعب الآخر بإنه يكمل خط مستقيم سواء أفقي أو
+
+10
+00:01:03,990 --> 00:01:12,230
+عمودي أو قطري، هذا الـ problem، طبعًا الـ universe
+
+11
+00:01:12,230 --> 00:01:15,610
+algorithm تتعامل مع الموضوع على أساس أنه
+
+12
+00:01:18,650 --> 00:01:23,590
+تذكر الخطوات اللي حكينا فيها، أول خطوة إيش؟ أنه to
+
+13
+00:01:23,590 --> 00:01:28,270
+generate اللي هو الـ search space كله، مظبوط، الـ tree
+
+14
+00:01:28,270 --> 00:01:34,310
+كلها، بمعنى آخر، علشان نحدد اللي هو الـ leaf nodes، و
+
+15
+00:01:34,310 --> 00:01:36,930
+هذه كانت الخطوة رقم واحد، صح؟ إيش الخطوة رقم
+
+16
+00:01:36,930 --> 00:01:44,670
+اثنين؟ بعد هيك نفسنا بدنا نعمل evaluation للـ leaf
+
+17
+00:01:44,670 --> 00:01:49,330
+nodes، نأخذ الأرقام هذه الـ evaluation اعتمادًا على الـ
+
+18
+00:01:49,330 --> 00:01:54,110
+evaluation
+
+19
+00:01:54,110 --> 00:01:59,210
+function أو الـ fitness function، بعد ذلك هذا رقم
+
+20
+00:01:59,210 --> 00:02:03,770
+اثنين، بعد ذلك رقم ثلاثة إيش بيصير؟ أن احنا بدنا
+
+21
+00:02:03,770 --> 00:02:09,510
+نعمل propagation للقيم من الـ leaf nodes
+
+22
+00:02:09,510 --> 00:02:14,070
+إلى الـ parent nodes، الـ propagation هذا هو اللي في
+
+23
+00:02:14,070 --> 00:02:19,500
+الآخر بيعطي الـ root node الـ value تبعها، علشان الـ
+
+24
+00:02:19,500 --> 00:02:27,020
+max يعرف من أولها إذا كان إيش هي الـ child الأفضل هنا
+
+25
+00:02:27,020 --> 00:02:38,840
+الثلاثة، معناته الـ P، صح الكلام؟ الكلام
+
+26
+00:02:38,840 --> 00:02:44,600
+هذا، قلنا إن فيه وسيلة
+
+27
+00:02:46,420 --> 00:02:54,020
+نختصر الـ search space، بدلًا من أننا نضطر
+
+28
+00:02:54,020 --> 00:02:59,920
+أن يتم زيارة كل الـ nodes أثناء عملية الـ evaluation
+
+29
+00:02:59,920 --> 00:03:06,480
+والـ propagation، لأن نقدر من بدري، مبكرًا، نعرف إنه
+
+30
+00:03:06,480 --> 00:03:11,520
+ما في داعي، إذا كنت هنا ورأيت الثلاثة، ممكن أعرف إن
+
+31
+00:03:11,520 --> 00:03:16,380
+ما في داعي أكمل، أفحص الـ باقي الـ siblings، هذا الكلام
+
+32
+00:03:16,380 --> 00:03:21,920
+اللي كان اسمه الـ alpha beta pruning، صح؟ الـ alpha
+
+33
+00:03:21,920 --> 00:03:27,720
+beta pruning، صحيحة
+
+34
+00:03:27,720 --> 00:03:34,780
+للكلام، صح، okay، اليوم راح نبدأ نطلع على فكرة الـ
+
+35
+00:03:34,780 --> 00:03:36,060
+alpha beta pruning
+
+36
+00:03:42,790 --> 00:03:48,890
+بشكل سريع، وبعدين
+
+37
+00:03:48,890 --> 00:04:00,910
+نرجع ثاني للـ algorithm مرة أخرى، نشوفها بشكل
+
+38
+00:04:00,910 --> 00:04:06,530
+كامل، يعني هنا الآن الـ A والـ B والـ C والـ D هي
+
+39
+00:04:06,530 --> 00:04:12,300
+خطوات في تنفيذ الـ minimax procedure نفسها، لاحظت
+
+40
+00:04:12,300 --> 00:04:18,840
+هنا أن الـ A لسة أنا مش عارف الـ value تبعها، عشان
+
+41
+00:04:18,840 --> 00:04:21,160
+أعرف الـ value تبعها، لازم أخش على الـ parent، على الـ
+
+42
+00:04:21,160 --> 00:04:24,900
+child تبعها، الـ child أنا مش عارف، لازم أشوف مين الـ
+
+43
+00:04:24,900 --> 00:04:27,400
+children تبعهم، الـ children تبعهم، افترضنا أن هدول
+
+44
+00:04:27,400 --> 00:04:31,060
+خلاص، dead end، leaf nodes، ما فيش ما عليك تقاربهها
+
+45
+00:04:31,060 --> 00:04:35,260
+فأول child بنشوفه، طبعًا الشغل كله depth first،
+
+46
+00:04:35,260 --> 00:04:40,120
+مظبوط، أول child بنشوفه، ثلاثة، ثلاثة الآن هادي،
+
+47
+00:04:40,120 --> 00:04:45,420
+لأن احنا هنا الـ node هذه في البداية في دور مين؟
+
+48
+00:04:45,420 --> 00:04:51,720
+الدور هذا دور مين؟ الدور هذا دور مين؟ الـ max، الآن
+
+49
+00:04:51,720 --> 00:04:58,080
+في دور الـ min، أنا واقف على الـ node هذه وأفحص الـ
+
+50
+00:04:58,080 --> 00:05:02,140
+children تبعهم، جيت للثلاثة، جيت لأول child، الـ
+
+51
+00:05:02,140 --> 00:05:06,480
+value تبعه ثلاثة، فالثلاثة هذه بتصير هي الـ beta
+
+52
+00:05:06,480 --> 00:05:11,440
+بتصير هي الـ beta value، الـ beta value هذا هو عبارة
+
+53
+00:05:11,440 --> 00:05:18,420
+عن قيمة اللي لسة مبدئية، اللي بقيم بيها الـ node هذه،
+
+54
+00:05:18,420 --> 00:05:21,800
+الـ node هذه قيمتها تعتمد على الـ children تبعها،
+
+55
+00:05:21,800 --> 00:05:25,660
+مظبوط؟ بس أنا لسة ما شفتش الـ child الثاني، فمبدئيًا،
+
+56
+00:05:25,660 --> 00:05:28,860
+مبدئيًا الـ child هذا الـ value تبعه هو الـ value
+
+57
+00:05:28,860 --> 00:05:34,660
+تبعنا، لما نشوف other children ونلاقي إنه فيه أقل
+
+58
+00:05:34,660 --> 00:05:40,910
+من الثلاثة، مظبوط؟ أقل ولا أكثر؟ أقل، لأن أنا في دور
+
+59
+00:05:40,910 --> 00:05:45,850
+الـ Min، الـ Min بدي يحمل value أقل واحد في الـ
+
+60
+00:05:45,850 --> 00:05:49,850
+children تبعهم، أو لا لا، أنا بستمر الآن أشوف الـ
+
+61
+00:05:49,850 --> 00:05:52,350
+child الثاني، إذا وجدت واحد أقل من الثلاثة في دوره
+
+62
+00:05:52,350 --> 00:05:57,770
+أحطه الـ value تبعه هو بدل الثلاثة في الـ beta، ماشي؟
+
+63
+00:05:57,770 --> 00:06:02,810
+الحاجة هذه الآن، وهذه
+
+64
+00:06:02,810 --> 00:06:06,750
+إيش لكل
+
+65
+00:06:06,750 --> 00:06:10,160
+node؟ لكل node هيبقى فيه لها two values، alpha و
+
+66
+00:06:10,160 --> 00:06:14,560
+beta، في
+
+67
+00:06:14,560 --> 00:06:18,260
+إيه، الآن استمرينا في الـ .. جينا الـ chart الثاني،
+
+68
+00:06:18,260 --> 00:06:25,420
+إيش الـ value تبعه؟ ماشي، الـ beta بتظهر زي ما هي،
+
+69
+00:06:25,420 --> 00:06:32,080
+مظبوطة؟ الـ beta بتظهر زي ما هي، هنا ثمانية، الـ beta
+
+70
+00:06:32,080 --> 00:06:40,280
+نفس الشيء بالنسبة للـ alpha value، الـ alpha value،
+
+71
+00:06:40,280 --> 00:06:43,540
+الـ
+
+72
+00:06:43,540 --> 00:06:50,360
+beta مفترض أنه عبارة عن أقل قيمة، الـ alpha من
+
+73
+00:06:50,360 --> 00:06:54,700
+ناحية ثانية، الـ alpha إيش راح تكون؟ أقل قيمة
+
+74
+00:06:54,700 --> 00:07:01,500
+بالنسبة لي الـ children بعدهم، الآن هذا الـ child، إن
+
+75
+00:07:01,500 --> 00:07:05,660
+عرفت الـ beta value تبعه، صح؟ خلاص انحسمت، لأنه خلصت
+
+76
+00:07:05,660 --> 00:07:08,340
+احنا الـ children تمامًا، انحسمت، أن الـ beta value
+
+77
+00:07:08,340 --> 00:07:12,850
+تبعه ثلاثة، الآن على الـ level اللي أعلى، احنا في دور
+
+78
+00:07:12,850 --> 00:07:17,970
+من الـ max، مظبوط؟ فالـ max الآن بيطلع على الـ
+
+79
+00:07:17,970 --> 00:07:21,650
+children تبعون الـ node هذه، الـ node هذه، الـ children
+
+80
+00:07:21,650 --> 00:07:27,690
+تبعونها بياخذ الـ value الأعلى تبع الـ children هذه،
+
+81
+00:07:27,690 --> 00:07:32,190
+الآن الـ value تبعها مبدئيًا هي ثلاثة، لازم أفحص من
+
+82
+00:07:32,190 --> 00:07:36,690
+الـ child الثاني عشان نشوف لو ربما هذا أعلى من
+
+83
+00:07:36,690 --> 00:07:45,370
+ثلاثة، صح؟ أعلى من ثلاثة، خشينا على C، C، أول
+
+84
+00:07:45,370 --> 00:07:50,590
+child فيها اثنين، تذكروا أننا خشينا على C، C، لأن في
+
+85
+00:07:50,590 --> 00:07:55,930
+دور الـ min، فأول child اثنين، نستمر في البحث أساسًا أن
+
+86
+00:07:55,930 --> 00:08:01,510
+نجد أقل من اثنين، طيب ليش أنا استمر أبحث عن أقل من
+
+87
+00:08:01,510 --> 00:08:06,510
+اثنين، إذا كان أنا الـ parent تبعي بدور عن أكثر من
+
+88
+00:08:06,510 --> 00:08:11,560
+ثلاثة؟ فهنا في هذه اللحظة، في هذه اللحظة مجرد ما أشوف
+
+89
+00:08:11,560 --> 00:08:17,240
+الاثنين، والاثنين هذه تترحل كـ beta value للـ C، صح؟ مش
+
+90
+00:08:17,240 --> 00:08:22,680
+هي تترحل، تترحل كـ beta value للـ C، تمام؟ فلأن الـ beta
+
+91
+00:08:22,680 --> 00:08:28,940
+value تبع الـ C أقل من الـ alpha value تبع الـ parent
+
+92
+00:08:28,940 --> 00:08:35,180
+تبعها، مين الـ parent تبع الـ C؟ الـ A، الـ A إيش الـ
+
+93
+00:08:35,180 --> 00:08:38,930
+parent، إيش الـ alpha value تبع الـ A؟ من أين جاءت
+
+94
+00:08:38,930 --> 00:08:43,630
+الثلاثة؟ هي المرشحة، نتيجة أنه احنا عرفنا أن الـ B
+
+95
+00:08:43,630 --> 00:08:48,010
+الـ child الأول، الـ value تبعه ثلاثة، فاترشحت الثلاثة
+
+96
+00:08:48,010 --> 00:08:53,890
+كـ alpha value للـ A، اترشحت بمعنى أنه احنا إذا بدنا
+
+97
+00:08:53,890 --> 00:08:58,890
+نستمر في البحث، فبدنا نبحث عن أفضل من الثلاثة، ماشي؟
+
+98
+00:08:58,890 --> 00:09:04,530
+أنا الآن على الـ C، الـ beta value تبع الـ C اثنين،
+
+99
+00:09:04,530 --> 00:09:12,720
+والاثنين هم أقل من الـ alpha تبع الـ parent، الـ
+
+100
+00:09:12,720 --> 00:09:25,280
+parent
+
+101
+00:09:25,280 --> 00:09:26,000
+اللي هو مين؟
+
+102
+00:09:48,160 --> 00:09:53,980
+الـ beta تبع الـ C اثنين، وهي أقل من الـ alpha تبع
+
+103
+00:09:53,980 --> 00:09:57,580
+الـ parent، الـ parent اللي هي parent تبع الـ C، يعني
+
+104
+00:09:57,580 --> 00:10:02,680
+هذا الكلام بقدر آخذه كقاعدة باستمرار، أنه لما نكون
+
+105
+00:10:02,680 --> 00:10:09,380
+أنا واقف على node، والـ node هذه في مستوى الـ Min، و
+
+106
+00:10:09,380 --> 00:10:15,040
+الـ beta تبعها، beta تبع هذه الـ node كان أقل من الـ
+
+107
+00:10:15,040 --> 00:10:22,240
+alpha تبع الـ parent بتاعها، بقدر أوقف وما احتاجش
+
+108
+00:10:22,240 --> 00:10:28,260
+أفحص باقي الـ children تبعونها، للـ node C هي الـ node
+
+109
+00:10:28,260 --> 00:10:32,880
+الـ children تبعونها باقي الـ children، والـ parent
+
+110
+00:10:32,880 --> 00:10:40,160
+إذا أنا الـ children تبعونها الآن قيمتهم أقل
+
+111
+00:10:40,160 --> 00:10:45,720
+من الـ alpha تبع الـ parent، بقدر أوقف، ما في داعي
+
+112
+00:10:45,720 --> 00:10:49,520
+أستمر، صح؟ أستمر، ليش؟ أستمر عشان أجيب أقل من الاثنين،
+
+113
+00:10:49,520 --> 00:10:55,560
+في الوقت اللي الـ parent ملزمة بأكثر من الثلاثة، حتى
+
+114
+00:10:55,560 --> 00:10:58,540
+لو كانت الاثنين هذه تساوي الـ alpha، بوقف برضه، بقى
+
+115
+00:10:58,540 --> 00:11:02,500
+صح؟
+
+116
+00:11:02,500 --> 00:11:05,100
+يعني كـ rule، أهمية إذا أنا فعلاً node
+
+117
+00:11:17,880 --> 00:11:24,860
+عندما تكون الـ node على level من الـ min، وأنا الـ
+
+118
+00:11:24,860 --> 00:11:29,540
+beta تبع الـ node
+
+119
+00:11:29,540 --> 00:11:36,600
+أقل من أو تساوي الـ alpha تبع الـ parent تبعها،
+
+120
+00:11:59,870 --> 00:12:04,210
+اعتبرها rule عامة،
+
+121
+00:12:04,210 --> 00:12:13,170
+هنا نفس الشيء حصل، هنا
+
+122
+00:12:13,170 --> 00:12:18,770
+نفس الشيء، لا أنا اختلف هنا، إيش؟ خلاصنا من هنا، وقفنا
+
+123
+00:12:18,770 --> 00:12:23,730
+هنا، ما نفحصش، هنا وقفنا وانتقلنا على طول إلى مين؟ الـ
+
+124
+00:12:23,730 --> 00:12:29,370
+node الثاني، الـ sibling الثاني، دي أول child اللي كان
+
+125
+00:12:29,370 --> 00:12:36,330
+أربعة، أربعة عشر، أترحلت كـ beta للـ D، هل الـ beta هذه أقل من
+
+126
+00:12:36,330 --> 00:12:38,930
+الـ alpha تبع الـ parent؟ لا، الـ alpha تبع الـ parent
+
+127
+00:12:38,930 --> 00:12:43,910
+ثلاثة، صح؟ الـ alpha ليه؟ اللي على
+
+128
+00:12:43,910 --> 00:12:51,030
+الشمال، بالـ beta اللي على اليمين، مظبوط؟ فالآن الأربعة عشر
+
+129
+00:12:51,030 --> 00:12:57,050
+هذه، لأنها أربعة عشر، بتترحل كـ value بدل القيم الأولى،
+
+130
+00:12:58,140 --> 00:13:03,600
+مظبوط؟ لأن الـ alpha أصلاً بتطلع على أي حاجة على الأكبر،
+
+131
+00:13:03,600 --> 00:13:08,280
+بتطلع على الأكبر، فلما جينا هذه أربعة عشر، أكبر من
+
+132
+00:13:08,280 --> 00:13:12,920
+الثلاثة اللي كانت موجودة، فاتحولت ليش؟ إلى أربعة عشر الآن،
+
+133
+00:13:12,920 --> 00:13:19,360
+أستمر، أستمر، لأنه قد يكون فيه أكثر من الـ أربعة عشر، أستمر
+
+134
+00:13:19,360 --> 00:13:23,700
+بأفحص، فلاقيها خمسة، تمام؟ لأن الخمسة هذه ما بتحيلش
+
+135
+00:13:23,700 --> 00:13:27,200
+محل الأربعة عشر، ليش؟ لأن عندك الـ ..
+
+136
+00:13:30,480 --> 00:13:37,580
+الخمسة عند الـ D بتحل محل الأربعة عشر عند الـ D؟ لو مش
+
+137
+00:13:37,580 --> 00:13:41,260
+موجودة أربعة عشر، بتحل محلها، ما في أربعة عشر هنا، أتت وهيأت،
+
+138
+00:13:41,260 --> 00:13:47,020
+كانت أربعة عشر، أجري اللي شفنا خمسة، بتحل الخمسة محل أربعة عشر؟
+
+139
+00:13:47,020 --> 00:13:51,050
+طبعًا بتحل، ليش؟ لأن هذا الـ D في level إيش؟ الـ
+
+140
+00:13:51,050 --> 00:13:53,970
+Minimum، والـ Minimum، والـ Minimum، والـ Minimum،
+
+141
+00:13:53,970 --> 00:14:00,950
+بدور الأصغر، القليل، كانت أربعة عشر، أخذتها، وبعدين جاءت اثنين،
+
+142
+00:14:00,950 --> 00:14:08,490
+أخذتها، صارت اثنين، الآن هذه اللي كانت كويسة لها، لكن لأنها
+
+143
+00:14:08,490 --> 00:14:14,030
+استبدلت، فبدها تستبدل وترجع من الثلاثة، هي الأفضل،
+
+144
+00:14:14,030 --> 00:14:19,130
+يعني هذا الكلام، لما شفت الأربعة عشر، أخذتها، وروح حالتها
+
+145
+00:14:19,130 --> 00:14:22,790
+فوق، لكن لما شفت الخمسة، أخذتها، وروح حالتها فوق،
+
+146
+00:14:22,790 --> 00:14:27,470
+لما شفت الاثنين، أخذتها، وروح حالتها فوق، لأنها عندها
+
+147
+00:14:27,470 --> 00:14:36,410
+إيش؟ أفضل منها، فبأخذ الأفضل منها، هذا الآن كقاعدة على
+
+148
+00:14:36,410 --> 00:14:39,650
+مستوى الـ min، على مستوى الـ max، على مستوى الـ max،
+
+149
+00:14:39,650 --> 00:14:44,430
+الآن بقدر أعكس الكلام على مستوى الـ max، بقول:  إن
+
+150
+00:14:47,840 --> 00:14:55,200
+الـ node at الـ max level، إيش أقول؟ إذا الـ alpha of
+
+151
+00:14:55,200 --> 00:15:00,960
+الـ n، إذا الـ alpha تبعت الـ node، إذا أنا واقف عليها،
+
+152
+00:15:00,960 --> 00:15:04,940
+max level، افترض
+
+153
+00:15:04,940 --> 00:15:12,040
+أنه هذا max level، مش min level، والـ node اللي أنا
+
+154
+00:15:12,040 --> 00:15:19,880
+واقف عليها، الـ alpha تبعها، الـ alpha تبعتها صارت أكبر
+
+155
+00:15:19,880 --> 00:15:26,000
+من الـ beta، أكبر من الـ beta تبعت من الـ parent، لأن
+
+156
+00:15:26,000 --> 00:15:32,420
+أنا الآن على max، هذا الآن يصير max، لأن
+
+157
+00:15:32,420 --> 00:15:37,460
+أنا أفترض أنه هو max، فأنا
+
+158
+00:15:37,460 --> 00:15:42,740
+جيت node، الـ node هذه الـ alpha تبعتها، أنا الآن max، الـ
+
+159
+00:15:42,740 --> 00:15:46,800
+node هذه، الـ child أترحلت، فصار عندنا الـ alpha تبعت الـ
+
+160
+00:15:46,800 --> 00:15:52,950
+parent، أكبر من الـ beta، تبع الـ alpha تبع الـ node،
+
+161
+00:15:52,950 --> 00:15:56,190
+أكبر من الـ beta تبع الـ parent، إيش بيصير في هذه
+
+162
+00:15:56,190 --> 00:16:01,810
+الحالة؟ لازم أوقف، ليش؟ لأنه أنا على max، وعندي شيء
+
+163
+00:16:01,810 --> 00:16:06,850
+كبير، وبدي أستمر عشان أجيب أكبر منه، وهذا الأكبر مش
+
+164
+00:16:06,850 --> 00:16:12,770
+بدي فيه، إذا كان أكبر من الـ beta تبع الـ parent، فقلت
+
+165
+00:16:12,770 --> 00:16:14,610
+لازم إيش؟ أوقف الـ search،
+
+166
+00:16:32,250 --> 00:16:40,290
+واضح هيك؟ اه، طيب خلينا الكلام هذا نشوف مثال ثاني
+
+167
+00:16:40,290 --> 00:16:45,730
+على الـ minimax problem، ونحاول
+
+168
+00:16:45,730 --> 00:16:52,070
+أولًا نحله بالـ minimax بدون pruning، وبعدين نطبق الـ
+
+169
+00:16:52,070 --> 00:16:57,990
+pruning عليه، افترض أن أنت عندك اللعبة، في أمامك
+
+170
+00:16:57,990 --> 00:17:04,770
+مجموعة من القطع، نقول سبع قطع، واتنين بيلعبوا اللعبة
+
+171
+00:17:04,770 --> 00:17:11
+
+223
+00:21:59,000 --> 00:22:03,180
+اتنين اتنين اتنين اتنين اتنين اتنين اتنين اتنين
+
+224
+00:22:03,180 --> 00:22:03,280
+اتنين اتنين اتنين اتنين اتنين اتنين اتنين اتنين
+
+225
+00:22:03,280 --> 00:22:05,140
+اتنين اتنين اتنين اتنين اتنين لو جسمت اتنين أول
+
+226
+00:22:05,140 --> 00:22:09,180
+واحدة في نفسها هي صح؟ في تانية واحدة أو واحد واحد
+
+227
+00:22:09,180 --> 00:22:18,540
+ثلاثة اه خلاص فيهم طب
+
+228
+00:22:18,540 --> 00:22:22,460
+هذه ممكن اجسم هذه الثلاثه أو اجسم هذه الثلاثه
+
+229
+00:22:22,460 --> 00:22:30,800
+صح؟ عشان هيكلع معايا واحد اتنين في زيها واحد واحد
+
+230
+00:22:30,800 --> 00:22:32,620
+اتنين ثلاثة هي اه
+
+231
+00:22:39,980 --> 00:22:45,660
+عشان نبسط خلاص يعني أنا اقسم حالتين سنة قسمت هذه
+
+232
+00:22:45,660 --> 00:22:49,720
+الثلاثه و هذه الثلاثه نفس الـ state نفس الوضع اللي
+
+233
+00:22:49,720 --> 00:22:55,660
+بيطلع معاها طيب هذه الآن نفسها نفس خياراتها كلهم
+
+234
+00:22:55,660 --> 00:23:01,560
+اللي هم اتنين هذول أو اتنين ماهم اللي هم اتنين
+
+235
+00:23:01,560 --> 00:23:02,040
+واحدين
+
+236
+00:23:06,740 --> 00:23:12,160
+اه أصلا هذه المفروضة أشرت عليها صح نشيلها من هنا
+
+237
+00:23:12,160 --> 00:23:14,840
+نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم
+
+238
+00:23:14,840 --> 00:23:17,740
+نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم
+
+239
+00:23:17,740 --> 00:23:18,300
+نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم
+
+240
+00:23:18,300 --> 00:23:22,620
+نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم
+
+241
+00:23:22,620 --> 00:23:24,360
+نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم
+
+242
+00:23:24,360 --> 00:23:24,840
+نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم
+
+243
+00:23:24,840 --> 00:23:29,180
+نعم نعم
+
+244
+00:23:29,180 --> 00:23:34,570
+نعم نبعد هيك نفسها واحد اتنين اتنين واحد واحد
+
+245
+00:23:34,570 --> 00:23:39,670
+اتنين واحد اتنين واحد اتنين واحد اتنين واحد اتنين
+
+246
+00:23:39,670 --> 00:23:40,790
+واحد اتنين واحد اتنين واحد اتنين واحد اتنين واحد
+
+247
+00:23:40,790 --> 00:23:44,630
+اتنين واحد اتنين واحد اتنين واحد اتنين واحد اتنين
+
+248
+00:23:44,630 --> 00:23:44,690
+واحد اتنين واحد اتنين واحد اتنين واحد اتنين واحد
+
+249
+00:23:44,690 --> 00:23:46,090
+اتنين واحد اتنين واحد اتنين واحد اتنين واحد اتنين
+
+250
+00:23:46,090 --> 00:23:47,130
+واحد اتنين واحد اتنين واحد اتنين واحد اتنين واحد
+
+251
+00:23:47,130 --> 00:23:50,750
+اتنين واحد اتنين واحد اتنين واحد اتنين واحد اتنين
+
+252
+00:23:50,750 --> 00:24:00,810
+واحد اتنين واحد اتنين
+
+253
+00:24:00,810 --> 00:24:06,680
+أو نفسك
+
+254
+00:24:06,680 --> 00:24:15,880
+أو
+
+255
+00:24:15,880 --> 00:24:26,280
+نفسك أو نفسك أو نفسك
+
+256
+00:24:26,280 --> 00:24:26,520
+أو نفسك أو نفسك أو نفسك أو نفسك أو نفسك أو نفسك أو
+
+257
+00:24:26,520 --> 00:24:28,860
+نفسك أو نفسك أو نفسك أو نفسك أو نفس لو أخذت هذه و
+
+258
+00:24:28,860 --> 00:24:33,800
+لا هذه و لا هذه هيطلع لك نفس الـ state هذه صح؟ طيب
+
+259
+00:24:33,800 --> 00:24:42,960
+هنا واحد واحد اتنين واحد و بعدين اتنين اللي هي هذه
+
+260
+00:24:42,960 --> 00:24:47,200
+اتنين واحدات و اتنين واحد واحد واحد اتنين واحد
+
+261
+00:24:47,200 --> 00:24:56,320
+اتنين واحد اتنين واحد اتنين اتنين اتنين اتنين
+
+262
+00:24:56,320 --> 00:24:56,640
+اتنين اتنين اتنين اتنين اتنين اتنين اتنين اتنين
+
+263
+00:24:56,640 --> 00:24:57,720
+اتنين اتنين اتنين اتنين اتنين اتنين اتنين اتنين
+
+264
+00:24:57,720 --> 00:24:59,690
+اتنين اتنين اتنين اتنين اتنين اتنين أول واحد ثلاثة
+
+265
+00:24:59,690 --> 00:25:07,630
+شغلان
+
+266
+00:25:07,630 --> 00:25:13,170
+اه نبتدي
+
+267
+00:25:13,170 --> 00:25:19,030
+الحل اش
+
+268
+00:25:19,030 --> 00:25:26,400
+كمان كم من هذه واحد واحد واحد واحد واحد أربعة خمسة
+
+269
+00:25:26,400 --> 00:25:34,900
+خمس و اتنين و بعدين اتنين و بعدين زيها مش زيها
+
+270
+00:25:34,900 --> 00:25:42,440
+زيها؟ و بعدين هي أكثر من واحد انها دي بدينا هنا في
+
+271
+00:25:42,440 --> 00:25:53,060
+level تبع max وهذا من وهذا max وهذا من وهذا max
+
+272
+00:25:53,060 --> 00:26:02,250
+وهذا منهنا هذه لمن مخسر و لا مكسر لو دور من هو
+
+273
+00:26:02,250 --> 00:26:09,290
+قدامه على الطاولة و الوضع زي ذلك مخسر المخسر لمن
+
+274
+00:26:09,290 --> 00:26:14,570
+مكسب ل max فده أحط أي one هذه الـ value تبقى مش هحط
+
+275
+00:26:14,570 --> 00:26:18,250
+تسعة أو أربعة ايش هحط تسعة أو أربعة هو يا اما مكسب
+
+276
+00:26:18,250 --> 00:26:23,250
+يا ما خسارة يعني تقييم الـ note يا اما win يا اما
+
+277
+00:26:23,250 --> 00:26:28,870
+lose when واحد will lose zero لأن لو كان عنده في
+
+278
+00:26:28,870 --> 00:26:35,050
+المقابل هنا في دور max وكان عنده اللوحة زي هيك
+
+279
+00:26:35,050 --> 00:26:40,270
+خسارة ل max لأنه مش هيقدر ما عنده خيار غير أنه يقسم
+
+280
+00:26:40,270 --> 00:26:50,430
+هذه ويقسم هذه فده هيخسر فهذا zero ل max هنا هذا
+
+281
+00:26:50,430 --> 00:26:51,570
+اه هذا مش leaf node
+
+282
+00:26:54,800 --> 00:26:58,240
+طيب هذه ليها مش leave node ايش الـ value تبعها لما
+
+283
+00:26:58,240 --> 00:27:04,520
+أنها parent ايش الـ child children اللي لها بس هذا
+
+284
+00:27:04,520 --> 00:27:11,540
+ايش بدها تاخد الـ value الـ value تبع الـ node اللي
+
+285
+00:27:11,540 --> 00:27:14,440
+جاي في max بده تكون الـ maximum تبع الـ children
+
+286
+00:27:14,440 --> 00:27:21,020
+تبعونها عموما في الشيء الـ child ايش الـ maximum هو
+
+287
+00:27:21,020 --> 00:27:25,570
+child واحد ايش الـ maximum تبعه واحد لأن هذه الـ
+
+288
+00:27:25,570 --> 00:27:33,870
+node لديها 8 children 1 0 1 1 يبقى 1 لماذا؟ لأنها
+
+289
+00:27:33,870 --> 00:27:41,950
+في دور الـ min الـ min يأخذ الـ minimum هذه الـ
+
+290
+00:27:41,950 --> 00:27:46,770
+node لديها child 1 لماذا؟ لأنها في دور الـ min
+
+291
+00:27:46,770 --> 00:27:51,730
+فتلقائيًا 0 هذه لديها child 1 و هي في دور الـ min
+
+292
+00:27:51,730 --> 00:27:56,250
+فتلقائيًا الـ value لها 0 بالأعلى هذه في دور الـ max
+
+293
+00:27:56,250 --> 00:28:01,970
+الـ children تبعونها هذا وهذا اتنين اتنين
+
+294
+00:28:01,970 --> 00:28:07,230
+Zero هذا الـ node لثلاثة children هذا قيمناها احنا
+
+295
+00:28:07,230 --> 00:28:13,170
+Zero هذه الـ node في دور الـ max
+
+296
+00:28:24,710 --> 00:28:30,910
+فهي Zero فهادد كله
+
+297
+00:28:30,910 --> 00:28:36,230
+Zero هيت شايد هيت شايد في عنا اشي غلطين يعني مفروض
+
+298
+00:28:36,230 --> 00:28:45,210
+أن يطلع معاه واحدة الاخيرة في دور
+
+299
+00:28:45,210 --> 00:28:53,250
+الـ min في دور الـ min تمام احنا ايش قلنا اه خسارة لمن فهي
+
+300
+00:28:53,250 --> 00:28:56,570
+max up لـ max الواحد هنا يعني max up لـ max طب أنت
+
+301
+00:28:56,570 --> 00:29:01,110
+بتضرر أني أحط 0 في الظلمة ما هي احنا بنحط الارقام
+
+302
+00:29:01,110 --> 00:29:08,710
+هذه relative to max صفر يعني مخسر لـ max واحد يعني
+
+303
+00:29:08,710 --> 00:29:13,250
+max up لـ max فهي اذا .. اه اذا ليه max .. هذه ايش
+
+304
+00:29:13,250 --> 00:29:18,550
+هذه؟ هذه مخسر لمن؟ مظبوط جاي في دوره وما عنده
+
+305
+00:29:18,550 --> 00:29:22,080
+خيار غير ايه بنقسم الاتنين الى هو ليش كانت بتصير
+
+306
+00:29:22,080 --> 00:29:26,820
+خسارة؟ ليش خسارة؟ لأنه بده يقسم الكوم الى جسمين
+
+307
+00:29:26,820 --> 00:29:32,160
+متساويين وهذا هي الخسارة لو أنت اضطريت انك تقسم
+
+308
+00:29:32,160 --> 00:29:36,420
+طبعا أنت بتقدر تقسم بدون ما يكونوا متساويين فانت
+
+309
+00:29:36,420 --> 00:29:43,640
+okay اذا اضطريت انك تتقسم ويكون الجسمين متساويين
+
+310
+00:29:43,640 --> 00:29:48,000
+فهذه خسارة خلاص اقتصادا لأن هو جيت خلينا نتبع على
+
+311
+00:29:48,000 --> 00:29:50,240
+الـ slide هذه بدل الذهب okay
+
+312
+00:29:55,060 --> 00:30:00,700
+عندي أنا هنا الـ state هي في دور مين اجت في دور max
+
+313
+00:30:00,700 --> 00:30:04,700
+فmax
+
+314
+00:30:04,700 --> 00:30:09,300
+وجه الحالة هذه بدل طرق يكسب الاتنين الى قسمين
+
+315
+00:30:09,300 --> 00:30:15,440
+متساويين فخسارة اذا ماشي حينها بدنا نطلع ثاني برضه
+
+316
+00:30:15,440 --> 00:30:18,120
+على الـ leaf nodes في الأول لازم تـ evaluate لازم ت
+
+317
+00:30:18,120 --> 00:30:22,900
+evaluate الـ leaf nodes هي دي الآن هي في وضع الـ min
+
+318
+00:30:23,610 --> 00:30:29,590
+وهي خسارة لمن فهي ماكس لـ max وين كمان فيه leaf
+
+319
+00:30:29,590 --> 00:30:34,270
+nodes هذا ليس leaf على هذا الـ level هذا leaf مظبوط
+
+320
+00:30:34,270 --> 00:30:40,030
+هذه leaf node في
+
+321
+00:30:40,030 --> 00:30:45,150
+دور الـ max وهي خسارة لـ max لأنه اذا اخذ أي واحد من
+
+322
+00:30:45,150 --> 00:30:49,990
+هؤلاء سيقسمهم مظبوط تستخدم فهي الـ zero لأن هؤلاء
+
+323
+00:30:49,990 --> 00:30:51,410
+بس هم الـ leaf nodes
+
+324
+00:30:54,120 --> 00:30:59,140
+لأن رحل على يعني propagation على الـ parents الـ
+
+325
+00:30:59,140 --> 00:31:05,540
+zero هنا في دور الـ min الـ zero بتروح للـ parent على
+
+326
+00:31:05,540 --> 00:31:13,020
+طول هنا في دور الـ max الـ واحد، مظبوط؟
+
+327
+00:31:13,020 --> 00:31:16,380
+لأن الـ parent هنا في دور الـ max ما عنده الـ child
+
+328
+00:31:16,380 --> 00:31:21,630
+واحد، الـ zero بياخد الـ zero صح؟ مظبوط هيك؟ هذا الـ
+
+329
+00:31:21,630 --> 00:31:24,290
+node ما عندكش الـ child واحد اللي هو الـ one اللي هي
+
+330
+00:31:24,290 --> 00:31:27,790
+تاخد one الان تعال على الـ level هذا فيه عندك الـ
+
+331
+00:31:27,790 --> 00:31:31,730
+node هذه الـ node هذه فيها two children الـ zero و
+
+332
+00:31:31,730 --> 00:31:36,190
+الـ one و هي في دور الـ min فبتاخد zero هذه الـ child
+
+333
+00:31:36,190 --> 00:31:39,390
+واحد على طول بتاخد زي ما هو هذه الـ child واحد
+
+334
+00:31:39,390 --> 00:31:43,850
+بتاخد الـ value نفسه وهذه برضه الـ node اللي هي
+
+335
+00:31:43,850 --> 00:31:47,550
+child واحد بتاخد الـ value نفسه صح الان تعال على
+
+336
+00:31:47,550 --> 00:31:52,020
+الـ level هذه هذه لـ two children و هي في دور الـ max
+
+337
+00:31:52,020 --> 00:31:57,120
+0 1 فتاخد one هذه one و zero فتاخد one هذه في الـ
+
+338
+00:31:57,120 --> 00:32:05,720
+child واحد فتاخد نفس الـ value نفس الـ واحد و واحد
+
+339
+00:32:05,720 --> 00:32:12,120
+فتاخد واحد اترحل في نهاية القمر على الـ level الـ
+
+340
+00:32:12,120 --> 00:32:17,820
+root اللي هو الواحد يعني الـ root هو الشبكة بتاعته؟
+
+341
+00:32:17,820 --> 00:32:22,900
+ايوة الـ root الان الـ root هو في دور الـ min و الـ
+
+342
+00:32:22,900 --> 00:32:28,160
+min أمامه الكوم الأساسي اللي فيه سبع حبات الان ايش
+
+343
+00:32:28,160 --> 00:32:34,400
+ياخد action؟ بدي ياخد الـ action اللي بيقطيه value
+
+344
+00:32:34,400 --> 00:32:38,520
+one مين هذول اللي بيقطيه value one؟ ثلاثة يمكن
+
+345
+00:32:38,520 --> 00:32:44,560
+بياخد أي واحد منهم randomly بالتساوي بنفس القيمة
+
+346
+00:32:44,560 --> 00:32:49,160
+الثالثة الآن افترض انه اخذ هذا الـ action الان في
+
+347
+00:32:49,160 --> 00:32:53,620
+دور الـ max والـ max أمامه هذا الـ action أمامه هذا
+
+348
+00:32:53,620 --> 00:32:57,600
+الـ state انا اسمه ياخد انهي action في two actions
+
+349
+00:32:57,600 --> 00:33:00,600
+two possible actions ياخد الـ action الـ value تبع
+
+350
+00:33:00,600 --> 00:33:07,300
+one مظبوط فمن الـ value تبع one هذا فياخد الـ action
+
+351
+00:33:07,300 --> 00:33:12,040
+ويقسم الأكوان من هذا الشكل يأتي دور الـ min الآن
+
+352
+00:33:14,430 --> 00:33:20,630
+مظبوط؟ فهذه أمامه خيار وحيد he has to play it this
+
+353
+00:33:20,630 --> 00:33:26,490
+way اللي هو أنه يكسب من 4 إلى 3 و 1 ما فيش غير هيك
+
+354
+00:33:26,490 --> 00:33:33,550
+صح؟ فالآن الإشارات الـ values هذه هي أصبحت كإنها
+
+355
+00:33:33,550 --> 00:33:39,590
+إشارات مرور بالنسبة للـ game أنه تروح و توجه و هي
+
+356
+00:33:39,590 --> 00:33:43,880
+مغمضة بعد عملية الـ evaluation للـ leave notes و بعد
+
+357
+00:33:43,880 --> 00:33:47,500
+عملية الـ propagation من الـ leave ل الـ parent notes
+
+358
+00:33:47,500 --> 00:33:51,100
+لما يوصل عندي evaluation للـ root خلاص الـ game
+
+359
+00:33:51,100 --> 00:33:58,780
+بتتبع من الـ values الـ value اللي تم اختياره على كل
+
+360
+00:33:58,780 --> 00:34:03,260
+note كنت دائما بتسأل عن الـ math بالنسبة للـ math
+
+361
+00:34:04,560 --> 00:34:08,560
+دائما تحسب بالنسبة للـ max دائما تحسب بالنسبة للـ
+
+362
+00:34:08,560 --> 00:34:12,660
+اتنين بس احنا قاعدة لما يكون اللعبة فيها min و max
+
+363
+00:34:12,660 --> 00:34:18,560
+و .. و .. و التقييم و التقييم للـ note يا اما zero
+
+364
+00:34:18,560 --> 00:34:22,520
+يا اما one ف الـ zero للـ max هو one للـ min و العكس
+
+365
+00:34:22,520 --> 00:34:27,300
+صحيح احنا حلنا ارقام و حطمناها بالنسبة للـ max صحيح و
+
+366
+00:34:27,300 --> 00:34:32,140
+العكس منها هو لـ Min يعني إذا حطيت واحد لـ Max فهو
+
+367
+00:34:32,140 --> 00:34:36,400
+نفسه هو نفسه الواحد هذا يعني Zero لـ Min صحيح ولا
+
+368
+00:34:36,400 --> 00:34:41,240
+لا هذا في حالة اللعبة هذه في حالة لعبة تانية زي
+
+369
+00:34:41,240 --> 00:34:44,560
+اللي شرحناها في الأول الـ Tic Tac Toe مشكلة عندك
+
+370
+00:34:44,560 --> 00:34:48,860
+الوضع عندك التقييم النوت الواحدة ما بتاخذش يا Zero
+
+371
+00:34:48,860 --> 00:34:57,220
+يا One تاخد تقييم في Range فاحنا بنعطي التقييم على
+
+372
+00:34:57,220 --> 00:35:02,820
+حسب ما هو الـ max الـ max بنعطي الـ node الـ value تبع
+
+373
+00:35:02,820 --> 00:35:14,140
+الـ max اللي بده على أساسه يشتغل خلّيني
+
+374
+00:35:14,140 --> 00:35:18,580
+الآن نطلع على مسألة الـ pruning على المثال هذا اللي
+
+375
+00:35:18,580 --> 00:35:23,300
+هو شبه بالمثال الأولى اللي تبع الـ tic-tac-toe عندك
+
+376
+00:35:23,300 --> 00:35:29,660
+تقييم اتنين ثلاثة لا أو هذه تقييم لـ Leaf nodes لأن
+
+377
+00:35:29,660 --> 00:35:34,260
+2 و 3 في دولة الـ Min الـ Max ماذا يأخذ؟ يأخذ الـ
+
+378
+00:35:34,260 --> 00:35:40,320
+3 هنا هذا يأخذ الـ 9 هذا الـ 0 وهذا الـ 7 وهذا الـ
+
+379
+00:35:40,320 --> 00:35:44,580
+2 وهذا الـ 6 تلقائيًا في دولة الـ Min يأخذ الـ 3
+
+380
+00:35:44,580 --> 00:35:49,920
+يأخذ الـ 0 يأخذ الـ 2 وفي دولة الـ Max يأخذ الـ 3
+
+381
+00:35:49,920 --> 00:35:53,260
+لو بدنا نعمل Pruning لهذا الكلام الآن Pruning
+
+382
+00:35:53,260 --> 00:36:00,500
+بمعنى أن أنابدي أجي أخلي الـ algorithm توفر جزء من
+
+383
+00:36:00,500 --> 00:36:05,460
+عملية الفحص لأن
+
+384
+00:36:05,460 --> 00:36:10,500
+على هذا الـ level الـ alpha لسه مش معروف دخلنا على
+
+385
+00:36:10,500 --> 00:36:14,960
+الـ child هذا لسه مش عارفين ايش الـ children تبعهم
+
+386
+00:36:14,960 --> 00:36:19,360
+دخلنا على الـ alpha وبالتالي الـ beta لسه مش معروف
+
+387
+00:36:19,360 --> 00:36:24,080
+هنا الـ alpha لسه مش معروف إلى أن شفنا الاتنين
+
+388
+00:36:24,500 --> 00:36:30,720
+الاتنين معناته alpha بساوي اتنين تمام؟ مظبوط؟ شفنا
+
+389
+00:36:30,720 --> 00:36:36,000
+الثلاثه الثلاثه أحسن من ال alpha فبنحوّنها لثلاثة
+
+390
+00:36:36,000 --> 00:36:41,280
+تمام؟ لأن ثبتت فش child آخر خلاص خلاص نقصد الثلاثه
+
+391
+00:36:41,280 --> 00:36:46,360
+ثبتت ال alpha على ثلاثة فخلاص أصبحت الـ value تبع هذه
+
+392
+00:36:46,360 --> 00:36:50,940
+الـ node ثلاثة مظبوط؟ حتى لأن ما عملناش any pruning
+
+393
+00:36:50,940 --> 00:36:55,810
+يعني ما قفرناش فحصنا كل الـ children هذه الثلاثه بما
+
+394
+00:36:55,810 --> 00:37:08,030
+أنها ثبتت تترقى كـ beta ل الـ parent الان شفنا
+
+395
+00:37:08,030 --> 00:37:12,510
+الثلاثه تترقى هنا الان هنا بنشوف الـ child الثاني
+
+396
+00:37:12,510 --> 00:37:18,090
+الـ child الثاني أنا لسه مش عارف مش عارف الـ value
+
+397
+00:37:18,090 --> 00
+
+445
+00:41:38,880 --> 00:41:43,040
+لسه الـ beta اللي تبقى في الـ beta مش محددة لازم
+
+446
+00:41:43,040 --> 00:41:50,040
+أكمل أنا على max اتنين، واحدة، هل واحدة دي أكثر من اتنين؟
+
+447
+00:41:50,040 --> 00:41:53,840
+فبتظل تسمى على اتنين لأن سبت هذه على اتنين، صلت هذه.
+
+448
+00:41:53,840 --> 00:41:58,500
+الـ beta إيش اتنين؟ لأن هل استمر أشوف الـ child هذا؟
+
+449
+00:41:58,500 --> 00:42:05,000
+ليش؟ لأن أنا في level هنا، أنا الآن هنا، والـ beta
+
+450
+00:42:05,000 --> 00:42:11,040
+تبعي أقل من الـ alpha تبع الـ parent، أنا هنا على إيش؟
+
+451
+00:42:11,040 --> 00:42:15,840
+اتمن level with
+
+452
+00:42:18,690 --> 00:42:26,730
+بيتا أقل من أقصى من Alpha، أنا هنا.. أنا هنا.. و
+
+453
+00:42:26,730 --> 00:42:30,130
+ثبتت معايا.. وثبتت معايا.. وعندي الـ Beta على
+
+454
+00:42:30,130 --> 00:42:35,150
+اتنين تمام.. الـ Beta على اتنين، والاتنين هذول اللي أقل
+
+455
+00:42:35,150 --> 00:42:39,270
+من الـ Alpha تبعت الـ parent، صح؟ صحيح.. هل أكمل
+
+456
+00:42:39,270 --> 00:42:43,290
+الآن؟ أخش في هذا الـ branch ولا لأ؟ لأ، صح.
+
+457
+00:42:43,290 --> 00:42:50,430
+لأن الـ Beta تبعت أقل من Alpha of الـ parent، فبواجف و
+
+458
+00:42:50,430 --> 00:42:57,730
+بحط إيش؟ وين بحط؟ هنا مظبوط؟ ما أخشش على الفرع هذا.
+
+459
+00:42:57,730 --> 00:43:14,330
+كله يعني هي نفس القاعدة، هي نفس القاعدة، أنا أنا أنا
+
+460
+00:43:14,330 --> 00:43:14,390
+أنا أنا أنا أنا أنا أنا أنا أنا أنا أنا أنا
+
+461
+00:43:14,390 --> 00:43:14,550
+أنا أنا أنا أنا أنا أنا أنا أنا أنا أنا أنا
+
+462
+00:43:14,550 --> 00:43:19,080
+أنا أنا أنا أنا أنا أنا أنا أنا أنا أنا هنا أنا
+
+463
+00:43:19,080 --> 00:43:24,380
+على main level، الـ beta تبعي أقل من، أو نفس القاعدة.
+
+464
+00:43:24,380 --> 00:43:31,620
+هي beta قزمة يابا، في خطأ هذي الشيء، لأ كيف؟ طب إذا
+
+465
+00:43:31,620 --> 00:43:34,480
+القاعدة بتبقى طولها ماشي، بس أنا هنا في main أنا
+
+466
+00:43:34,480 --> 00:43:41,120
+هنا في max، أنا هنا في main أنا
+
+467
+00:43:41,120 --> 00:43:44,760
+هذه القاعدة أحطها هي نفسها، بخط نظر أنا الـ level
+
+468
+00:43:44,760 --> 00:43:49,590
+max، أكتب نفس القاعدة، أنا هنا على الـ max، وأنا هنا
+
+469
+00:43:49,590 --> 00:43:53,750
+على الـ min، طيب ماشي، عملياً احنا الآن بنكون طلعنا
+
+470
+00:43:53,750 --> 00:43:57,870
+على الـ alpha beta pruning، الـ alpha، الـ minimax
+
+471
+00:43:57,870 --> 00:44:01,310
+procedure في حد ذاتها، وبعدها الـ minimax with
+
+472
+00:44:01,310 --> 00:44:05,610
+alpha beta pruning عشان فكرة إن احنا نقلص الـ
+
+473
+00:44:05,610 --> 00:44:10,270
+search space، بيضل شغل آخر، وهي إن أحياناً الـ
+
+474
+00:44:10,270 --> 00:44:15,370
+adversarial games بتبقى multiplayer، يعني مش بس
+
+475
+00:44:15,370 --> 00:44:21,050
+اتنين خصمين، ممكن يبقى ثلاثة أو أربعة أو أكثر في هذه
+
+476
+00:44:21,050 --> 00:44:25,530
+الحالة، الـ evaluation تبع الـ node الواحدة بيبقى
+
+477
+00:44:25,530 --> 00:44:31,530
+vector، يعني عدة قيم، يعني مثلاً أنا عندي هنا اللعب
+
+478
+00:44:31,530 --> 00:44:35,050
+الأول A، اللعب بيبقى بيبقى بيبقى بيبقى بيبقى بيبقى
+
+479
+00:44:35,050 --> 00:44:35,990
+بيبقى بيبقى بيبقى بيبقى بيبقى بيبقى بيبقى بيبقى
+
+480
+00:44:35,990 --> 00:44:37,750
+بيبقى بيبقى بيبقى بيبقى بيبقى بيبقى بيبقى بيبقى
+
+481
+00:44:37,750 --> 00:44:38,550
+بيبقى بيب
+
+482
+00:44:46,670 --> 00:44:51,130
+هي تقييم الـ node هذه بالنسبة لـ A، الاتنين هذه هي
+
+483
+00:44:51,130 --> 00:44:55,190
+تقييم نفس الـ node بس بالنسبة لـ B، بس الـ six هذه
+
+484
+00:44:55,190 --> 00:45:03,490
+تقييم بالنسبة لـ C، فالآن الـ player لما بدي يلعب أو
+
+485
+00:45:03,490 --> 00:45:07,930
+لما يجي دوره، بدي يبص بس على التقييم الخاص بأبيه
+
+486
+00:45:07,930 --> 00:45:12,950
+ماشي، إنما الـ concept هي هي نفس قالية العمل بالنسبة
+
+487
+00:45:12,950 --> 00:45:16,230
+لـ minimax procedure، كل الاختلاف إنه لما بنعمل
+
+488
+00:45:16,230 --> 00:45:23,590
+evaluation للنوت في الـ two player case بنعمل
+
+489
+00:45:23,590 --> 00:45:31,130
+تقييم لـ الـ max، إنما في الـ multiplayer case بنعمل
+
+490
+00:45:31,130 --> 00:45:34,810
+تقييم لكل واحد من الـ players، لكل واحد من الـ
+
+491
+00:45:34,810 --> 00:45:37,790
+players، إذا هم ثلاثة، إذا هم أربعة، والتقييم هذه
+
+492
+00:45:37,790 --> 00:45:41,130
+بيجي على شكل vector، يعني مصفوفة متكونة من اتنين من
+
+493
+00:45:41,130 --> 00:45:45,250
+ثلاثة أو أكثر من العناصر، كل لاعب بيبص بس على
+
+494
+00:45:45,250 --> 00:45:49,810
+التقييم تبعه، وعلى أساسه بيقرر إيش اللي هو الـ
+
+495
+00:45:49,810 --> 00:45:53,880
+state اللي ياخده، ماشي في هذا الـ.. الآن بنكون احنا
+
+496
+00:45:53,880 --> 00:45:58,740
+خلصنا موضوع الـ adversary الـ search، وعملياً نكون
+
+497
+00:45:58,740 --> 00:46:01,180
+خلصنا الـ search كله، كل اللي بدنا إياه عن الـ search
+
+498
+00:46:01,180 --> 00:46:06,660
+خلصناه، المحاضرة الجاية إن شاء الله بنبدأ موضوع جديد
+
+499
+00:46:06,660 --> 00:46:11,880
+ومن الكتاب الثاني اللي هو الكتاب تبع الـ guide to
+
+500
+00:46:11,880 --> 00:46:15,880
+intelligence systems، تمام؟ ماشي، الاتنين الموجودين
+
+501
+00:46:15,880 --> 00:46:17,840
+في الـ drop box
diff --git a/PL9fwy3NUQKwYT4Ayhm-3qTiT1ILbX-hwD/rR7QicwJyV8.srt b/PL9fwy3NUQKwYT4Ayhm-3qTiT1ILbX-hwD/rR7QicwJyV8.srt
new file mode 100644
index 0000000000000000000000000000000000000000..aa9e5a87284a5849aa3c1236267285f52e211abd
--- /dev/null
+++ b/PL9fwy3NUQKwYT4Ayhm-3qTiT1ILbX-hwD/rR7QicwJyV8.srt
@@ -0,0 +1,919 @@
+1
+00:00:00,960 --> 00:00:05,480
+بسم الله الرحمن الرحيم هذه المحاضرة الثانية محاضرة
+
+2
+00:00:05,480 --> 00:00:12,980
+أدب الأطفال، الكتاب المقرر علينا في هذا الفصل هو
+
+3
+00:00:12,980 --> 00:00:18,000
+النص الأدبي للأطفال من تأليف سعد أبو الرضا. نحن
+
+4
+00:00:18,000 --> 00:00:21,880
+أخذنا في المحاضرة الأولى حديثًا عن الأدب والثقافة
+
+5
+00:00:21,880 --> 00:00:29,000
+فتحدثنا عن مفهوم الأدب والتطور الدلالي للمفردة
+
+6
+00:00:29,000 --> 00:00:34,520
+الأدب ما بين الجانب الحسي المادي والجانب المعنوي،
+
+7
+00:00:34,520 --> 00:00:39,280
+ثم بعد ذلك تحدثنا عن الثقافة وعلاقة الثقافة
+
+8
+00:00:39,280 --> 00:00:44,780
+بالأدب، وكيف يمكن للأدب أن يعبر عن الثقافة، ثم بعد
+
+9
+00:00:44,780 --> 00:00:51,230
+ذلك انتقلنا للحديث عن التجسيد، التجسيد الفني للأدب،
+
+10
+00:00:51,230 --> 00:00:57,550
+وأهمية هذا التجسيد الفني للأدب، وانعكاسات هذا
+
+11
+00:00:57,550 --> 00:01:02,050
+التجسيد على الأدب وعلى الطفل، ومحيط استقبال الأدب،
+
+12
+00:01:02,050 --> 00:01:07,250
+وأدب الأطفال، وكيف يهيئ التجسيد الفني للطفل
+
+13
+00:01:07,250 --> 00:01:12,830
+لاستقبال الأدب. هذه المحاضرة، التي هي المحاضرة
+
+14
+00:01:12,830 --> 00:01:16,090
+الثانية، موجودة في الكتاب تحت عنوان أهمية أدب
+
+15
+00:01:16,090 --> 00:01:20,730
+الأطفال الإسلامي، أهمية
+
+16
+00:01:20,730 --> 00:01:28,290
+أدب الأطفال الإسلامي. تكمن هنا أهمية الأدب بالنسبة
+
+17
+00:01:28,290 --> 00:01:34,130
+للطفل. قبل أن نعرف هذه الأهمية، لابد أن نتعرف على
+
+18
+00:01:34,130 --> 00:01:40,810
+احتياجات الأطفال، واهتمامات الأطفال، ومشكلات
+
+19
+00:01:40,810 --> 00:01:49,390
+الأطفال. لابد لمن يدرس أو يكتب للطفل أن يعرف مشكلات
+
+20
+00:01:49,390 --> 00:01:52,390
+الأطفال، لابد أن يتعرف كذلك، ويقدم لهم الحلول لهذه
+
+21
+00:01:52,390 --> 00:02:00,030
+المشكلات. ومن هنا يستخدم الأدب في
+
+22
+00:02:00,030 --> 00:02:06,440
+زرع القيم والمبادئ والمثل للأطفال، ومن هنا نستطيع
+
+23
+00:02:06,440 --> 00:02:13,360
+أن نقول إن أدب الأطفال يستخدم وسيلة حضارية إنسانية
+
+24
+00:02:13,360 --> 00:02:18,820
+فكرية علمية، إلى آخره، من أجل إرسال هذه القيم، وسيلة
+
+25
+00:02:18,820 --> 00:02:27,340
+إذن الطفل اليوم هو رجل المستقبل، ولابد هنا أن
+
+26
+00:02:27,340 --> 00:02:33,530
+نبلور شخصية هذا الطفل عن طريق الأدب بكل فنون
+
+27
+00:02:33,530 --> 00:02:38,490
+المتنوعة، سواء كان قصة أو مسرحية أو نشيدًا أو غير ذلك.
+
+28
+00:02:38,490 --> 00:02:45,770
+إذن هناك وسائل ينقل من خلالها الأدب أو يتوظف من خلال
+
+29
+00:02:45,770 --> 00:02:50,670
+الأدب من أجل التأثير في الأطفال، وجذب انتباه
+
+30
+00:02:50,670 --> 00:02:55,130
+الأطفال، من أجل غرس القيم والمبادئ والأفكار
+
+31
+00:02:55,130 --> 00:03:02,430
+المتنوعة التي يريد الأب أو المعلم أن يرسخها في وجود
+
+32
+00:03:02,430 --> 00:03:07,090
+الأطفال. إذن لابد للأدب أن يشبع اهتمامات، اهتمامات
+
+33
+00:03:07,090 --> 00:03:12,310
+الطفل، لابد للأدب أن يلبّي احتياجات ورغبات الطفل،
+
+34
+00:03:12,310 --> 00:03:17,770
+لابد للأدب أن يقدم للطفل غذاءً نفسيًا وفكريًا، وغذاءً
+
+35
+00:03:17,770 --> 00:03:24,670
+معنويًا، لابد للأدب أن يرقى بالأطفال
+
+36
+00:03:25,700 --> 00:03:30,000
+على مستوى الفكري، وعلى مستوى الخيال، وعلى مستوى النمو
+
+37
+00:03:30,000 --> 00:03:35,640
+الحسي. لذلك هنا لابد أن يقدم الأدب للطفل معلومات
+
+38
+00:03:35,640 --> 00:03:44,160
+علمية، فنية، جمالية، دينية، تاريخية، قومية، أيّ الأخرى.
+
+39
+00:03:44,160 --> 00:03:48,760
+وكذلك لابد للأدب أن يتوافق مع استعدادات الطفل
+
+40
+00:03:48,760 --> 00:03:56,490
+وميوله نحو اللعب، وبالتالي الأدب يكون وسيلة ترفيهية
+
+41
+00:03:56,490 --> 00:04:04,550
+ووسيلة تعليمية للأطفال. لابد أن يكتشف الطفل من خلال
+
+42
+00:04:04,550 --> 00:04:11,190
+الأدب أشياءً جديدة، ويترك للطفل حرية الاختيار لأنواع
+
+43
+00:04:11,190 --> 00:04:17,690
+الأدبية التي ينسجم معها، وتحقق احتياجاته، وتلبي
+
+44
+00:04:17,690 --> 00:04:29,040
+رغباته. كذلك لابد أن يتحول الطفل في معرفته للأدب من
+
+45
+00:04:29,040 --> 00:04:37,800
+الجانب الترفيهي إلى الجانب التعليمي، ومن هنا تحدث
+
+46
+00:04:37,800 --> 00:04:45,760
+مشاركة وجدانية، عقلية، خيالية، نفسية بين فنون الأدب
+
+47
+00:04:45,760 --> 00:04:53,300
+وبين الطفل، وبالتالي تتحقق إشباع اهتمامات
+
+48
+00:04:55,280 --> 00:05:00,680
+ورغبات الطفل، لذلك
+
+49
+00:05:00,680 --> 00:05:07,220
+نقول إن الطفل بحاجة إلى أدب خاص في السنوات الأولى،
+
+50
+00:05:07,220 --> 00:05:13,020
+السنوات التكوينية التي تبلور شخصية الطفل. لذلك تكمن
+
+51
+00:05:13,020 --> 00:05:21,520
+أهمية أدب الأطفال في نقل المعرفة إلى الطفل، ونقل
+
+52
+00:05:21,520 --> 00:05:27,420
+التجارب البشرية. أدب الطفل يزيد الثروة اللغوية عند
+
+53
+00:05:27,420 --> 00:05:32,280
+الأطفال. أدب الطفل ينمي الإحساس عند الأطفال بجمال
+
+54
+00:05:32,280 --> 00:05:38,740
+الكلمات وإيقاع الكلمات، وكذلك يشعر الطفل بالقوة
+
+55
+00:05:38,740 --> 00:05:43,420
+التأثيرية لهذه الإيقاعات. لذلك هنا نجد أن الطفل
+
+56
+00:05:43,420 --> 00:05:48,310
+يستطيع من خلال الأدب أن يحقق رغبات متعددة، فيكون من
+
+57
+00:05:48,310 --> 00:05:52,470
+خلال الأدب أكثر قبولاً للحياة، وأكثر تفهماً
+
+58
+00:05:52,470 --> 00:06:00,810
+لمتغيرات الحياة، وكذلك أكثر تكيفاً مع احتياجات الحياة.
+
+59
+00:06:00,810 --> 00:06:06,570
+وبالتالي يستطيع الأدب أن يربط ما بين الواقع المعاش
+
+60
+00:06:06,570 --> 00:06:12,900
+والماضي، ويؤدي الدور المستقبلي. ومن هنا نقول إن الأدب
+
+61
+00:06:12,900 --> 00:06:20,580
+له دور مهم في غرس القيم الدينية والمبادئ الأخلاقية
+
+62
+00:06:20,580 --> 00:06:28,200
+الإسلامية التي تعزز بناء شخصية الطفل. لذلك نجد هناك
+
+63
+00:06:28,200 --> 00:06:34,680
+علاقة وثيقة ما بين الكلمة والمعتقد والعقيدة
+
+64
+00:06:34,680 --> 00:06:38,760
+الإسلامية، وبالتالي
+
+65
+00:06:38,760 --> 00:06:45,660
+يتجاوز الأدب كونه وسيلة ترفيهية إلى وسيلة تعليمية.
+
+66
+00:06:45,660 --> 00:06:49,900
+في البداية، الأدب يكون وسيلة ترفيهية، ثم مع النمو و
+
+67
+00:06:49,900 --> 00:06:54,540
+التطور الذي يحدث للطفل، يتحول من الوسيلة الترفيهية
+
+68
+00:06:54,540 --> 00:07:04,460
+إلى وسيلة تعليمية. فنلاحظ أن الأدب يجسد جانبًا وجدانيًا،
+
+69
+00:07:04,460 --> 00:07:10,940
+يعزز جانب التعاون مع باقي الأطفال، يدعم
+
+70
+00:07:12,960 --> 00:07:21,360
+التواصل بين الأطفال، يشكل وجدان الأطفال، يثقل مشاعر
+
+71
+00:07:21,360 --> 00:07:26,780
+الأطفال، يعزز نشأة سوية سليمة لديهم، يعزز قيم
+
+72
+00:07:26,780 --> 00:07:33,260
+الحق والخير والجمال للأطفال. لذلك هنا نجد أن أدب
+
+73
+00:07:33,260 --> 00:07:38,560
+الأطفال، أدب الأطفال يجب أن ينهض بما يدعو إليه
+
+74
+00:07:38,560 --> 00:07:42,830
+الإسلام. بمعنى أن أدب الطفل لابد أن يحمل في داخله
+
+75
+00:07:42,830 --> 00:07:49,950
+رسالة، وهذه الرسالة تعزز القيم الإسلامية والمبادئ
+
+76
+00:07:49,950 --> 00:07:55,570
+الدينية لديه، بحب العلم، والسعادة في رضا الله، والقيم
+
+77
+00:07:55,570 --> 00:07:59,590
+الدينية المتعلقة بالصدق والإخلاص والأمانة والمحبة،
+
+78
+00:07:59,590 --> 00:08:04,610
+وغير ذلك. بالإضافة إلى ذلك، أن أدب الطفل ينمي الخيال
+
+79
+00:08:04,610 --> 00:08:08,790
+للأطفال، ويطلق لديهم التفكير
+
+80
+00:08:11,310 --> 00:08:17,110
+في أشياء متعددة ومتنوعة. وبالتالي نستطيع أن نقول إن
+
+81
+00:08:17,110 --> 00:08:22,770
+أدب الطفل يسهم إسهامًا كبيرًا في تحقيق الاستقرار
+
+82
+00:08:22,770 --> 00:08:30,210
+والتوازن النفسي لدى الأطفال. بالإضافة إلى ذلك، نقول إن
+
+83
+00:08:30,210 --> 00:08:38,810
+أهمية أدب الطفل تكمن في أنه يساعد على بناء الشخصية
+
+84
+00:08:38,810 --> 00:08:45,510
+للطفل، يساعد على بناء الطفل من ناحية نفسية، ومن ناحية
+
+85
+00:08:45,510 --> 00:08:52,210
+عقلية، وخيالية، مراعية الخصائص، لأن كل مراحل من مراحل
+
+86
+00:08:52,210 --> 00:08:59,350
+الطفولة لها ما يناسبها من الأدب. فلذلك الأدب يقدم
+
+87
+00:08:59,350 --> 00:09:05,530
+للأطفال معيارًا أخلاقيًا، دينيًا، اجتماعيًا، معيارًا
+
+88
+00:09:05,530 --> 00:09:13,210
+ترفيهيًا. لذلك لا يمكن أن ينفصل المعيار الأخلاقي أو
+
+89
+00:09:13,210 --> 00:09:18,310
+الديني أو الموضوعي عن المعيار الفني. لذلك نستطيع أن
+
+90
+00:09:18,310 --> 00:09:22,890
+نقول إن أدب الطفل في داخله بنية متراكبة لا يمكن أن
+
+91
+00:09:22,890 --> 00:09:31,850
+ينفصل فيها الشكل عن المضمون، فكلاهما يعزز وجود
+
+92
+00:09:31,850 --> 00:09:37,310
+الآخر، لأن الأدب تعبير عن الحضارة الإنسانية. ومن هنا
+
+93
+00:09:37,310 --> 00:09:45,610
+نقول إن الطفل بحاجة إلى أن يتعرف على ذاته، يتعرف على
+
+94
+00:09:45,610 --> 00:09:50,310
+البيئة المحيطة به. كيف يمكن أن يتعرف على ذاته أو
+
+95
+00:09:50,310 --> 00:09:54,770
+يتعرف على البيئة المحيطة به؟ الأدب، أدب الأطفال بكل
+
+96
+00:09:54,770 --> 00:09:59,950
+أنواعه الأدبية، سواء كان شعرًا أو نثرًا، يسهم إسهامًا
+
+97
+00:09:59,950 --> 00:10:06,070
+كبيرًا في تهيئة الفرصة اللازمة أمام الطفل للتعرف على
+
+98
+00:10:06,070 --> 00:10:12,010
+ذاته، وعلى البيئة المحيطة به، حيث
+
+99
+00:10:12,010 --> 00:10:19,770
+يقدم مجموعًا من الخبرات للأطفال. لذلك أدب الطفل يسهم
+
+100
+00:10:19,770 --> 00:10:25,570
+في صياغة عقل الطفل، وتنمية الخيال لديه. أدب الطفل من
+
+101
+00:10:25,570 --> 00:10:33,610
+أهميته ومكانته البناءة، ينمي الإحساس عند الأطفال، يزيد
+
+102
+00:10:34,250 --> 00:10:41,310
+وعي الطفل لفهم الواقع المعاش، ووعيه بالماضي،
+
+103
+00:10:41,310 --> 00:10:46,990
+واستشرافه لآفاق المستقبل. لذلك أدب الطفل يعد وسيطًا
+
+104
+00:10:46,990 --> 00:10:53,450
+تربويًا، يتيح الفرصة أمام الأطفال لمعرفة كثير من
+
+105
+00:10:53,450 --> 00:10:56,750
+الإجابات لكثير من الأسئلة،
+
+106
+00:10:56,750 --> 00:11:03,000
+والاستفسارات التي تدور في أذهانهم. أدب الطفل يعتبر
+
+107
+00:11:03,000 --> 00:11:07,880
+وسيطًا تربويًا، يتيح الفرصة أمام الأطفال لمعرفة
+
+108
+00:11:07,880 --> 00:11:13,480
+الإجابات عن كثير من الأسئلة والاستفسارات، ومحاولات
+
+109
+00:11:13,480 --> 00:11:18,980
+الكشف والتعرف على الأشياء من حولهم. لذلك أدب الطفل
+
+110
+00:11:18,980 --> 00:11:25,600
+أيضًا ينقل للأطفال الخبرات، سواء في الماضي أو في الواقع
+
+111
+00:11:25,600 --> 00:11:33,230
+المعاش. أدب الأطفال يتيح الفرصة أمام الطفل لتحقيق
+
+112
+00:11:33,230 --> 00:11:41,670
+الثقة بالنفس، من خلال ثقل شخصية الطفل، التي يعمل أدب
+
+113
+00:11:41,670 --> 00:11:46,590
+على أن يشارك الطفل في الأعمال الجماعية، كالمسرحيات
+
+114
+00:11:46,590 --> 00:11:53,070
+والتمثيل والأناشيد، تكون أعمالًا جماعية وليست فردية،
+
+115
+00:11:53,070 --> 00:11:59,170
+فيعزز هذه فرصة الاحتكاك بالآخرين، وهنا تكمن أو يعزز
+
+116
+00:11:59,170 --> 00:12:09,750
+الثقة بالنفس. كذلك نجد أن أدب الطفل يمكن الأطفال من
+
+117
+00:12:09,750 --> 00:12:20,110
+التحرر من العادات والتقاليد السيئة، ويرسخ لديهم
+
+118
+00:12:20,110 --> 00:12:29,250
+الخبرات والقيم البناءة، الخبرات والقيم البناءة، يوفر
+
+119
+00:12:29,250 --> 00:12:36,910
+للأطفال أسباب الترويح والترفيه عن أنفسهم، ويوفر لهم
+
+120
+00:12:36,910 --> 00:12:44,930
+القيم العلمية والدينية والتربوية، وما يتعلق بالبيئة
+
+121
+00:12:44,930 --> 00:12:50,430
+المحيطة بهم. لذلك نجد في أدب الطفل جوانبًا تاريخية،
+
+122
+00:12:50,430 --> 00:12:58,120
+تزود الطفل بما يتعلق بثقافة الماضي. نجد في أدب
+
+123
+00:12:58,120 --> 00:13:05,380
+الطفل نواحي دينية، وهي قصص دينية، نلاحظ أنها
+
+124
+00:13:05,380 --> 00:13:11,080
+كنواحي قومية، الأحداث والشخصيات التي تسهم في بناء
+
+125
+00:13:11,080 --> 00:13:16,500
+التاريخ. كذلك نجد هناك نواحي ثقافية، تزود الأطفال
+
+126
+00:13:16,500 --> 00:13:19,440
+بمعلومات مختلفة عن الثقافات، وعن الحضارات، وعن
+
+127
+00:13:19,440 --> 00:13:26,200
+التقاليد، وعن الأمم المختلفة، والشعوب الأخرى. في
+
+128
+00:13:26,200 --> 00:13:30,660
+نواحي عقلية، تزود الأدب الطفل بالنواحي العقلية، ينمي
+
+129
+00:13:30,660 --> 00:13:38,080
+لديهم فهم العلم، والتطور التكنولوجي، والحضارة، يعزز
+
+130
+00:13:38,080 --> 00:13:43,180
+لديهم فهم طبيعة المقتنيات الحديثة الإلكترونية، كذلك
+
+131
+00:13:43,180 --> 00:13:50,580
+يعزز لديهم نواحي أخلاقية، بالارتباط بمحاكاة الأنبياء
+
+132
+00:13:50,580 --> 00:13:55,000
+والرسل والصحابة والتابعين، والشخصيات المتنوعة. يعزز
+
+133
+00:13:55,000 --> 00:13:59,400
+لديهم كذلك. أدب الأطفال جوانب، النواحي الترفيهية،
+
+134
+00:13:59,400 --> 00:14:06,650
+والنفسية. الطفل يجد هناك جوانب ترفيهية، يتسلى من
+
+135
+00:14:06,650 --> 00:14:14,570
+خلال... يتسلى، ويرتاح... ويرفع عن نفسه من خلال
+
+136
+00:14:14,570 --> 00:14:20,590
+الاستماع أو القراءة في أدب الأطفال. هذا ما هو، ما
+
+137
+00:14:20,590 --> 00:14:27,730
+يتعلق بأدب، أو أهمية أدب الطفل.
+
+138
+00:14:30,900 --> 00:14:36,300
+نأتي إلى الجزء الآخر من هذه المحاضرة، فيما يتعلق
+
+139
+00:14:36,300 --> 00:14:43,160
+بأدب الأطفال. نبدأ بالمفهوم. إذن، كان أدب الأطفال
+
+140
+00:14:43,160 --> 00:14:48,040
+بمعناه العام، بمعنى العام، ماذا يقصد به؟ إنتاج عقلي
+
+141
+00:14:48,040 --> 00:14:51,200
+مدوّن
+
+142
+00:14:51,200 --> 00:14:57,700
+في الكتب، وموجه لمن؟ للأطفال. هذا بمعناه العام، يعني
+
+143
+00:14:57,700 --> 00:15:03,050
+إنتاجًا عقليًا يكتبه الكبار في كتب، ويتم توجيه هذه
+
+144
+00:15:03,050 --> 00:15:06,770
+الكتابات إلى الأطفال، سواء في المقررات الدراسية،
+
+145
+00:15:06,770 --> 00:15:11,690
+القراءة الإلزامية التعليمية، أو في القراءة الحرة.
+
+146
+00:15:11,690 --> 00:15:21,370
+ومن هنا بالمعنى العام. أما المعنى الخاص، نقول إن أدب
+
+147
+00:15:21,370 --> 00:15:27,430
+الطفل هو الكلام الجيد الجميل، كلام جيد وجميل يجذب
+
+148
+00:15:27,430 --> 00:15:33,080
+اهتمام الطفل، وماذا يحدث في نفوسهم أيضًا؟ متعة فنية،
+
+149
+00:15:33,080 --> 00:15:43,420
+ويثري فكر الأطفال. وهذا الأدب، سواء كان أدبًا شفويًا،
+
+150
+00:15:43,420 --> 00:15:51,160
+مشفوعًا بالكلام، أو أدبًا تحريريًا بالكتابة. وهذا
+
+151
+00:15:51,160 --> 00:15:56,910
+الأدب، ما يتعلق بالجانب الشفوي أو التحريري، يختلف حسب
+
+152
+00:15:56,910 --> 00:16:00,850
+ما هو، مراحل نمو الطفل. لأن في مراحل من المراحل لا
+
+153
+00:16:00,850 --> 00:16:05,130
+يستطيع الطفل أن يعتمد على نفسه في القراءة، فيلجأ
+
+154
+00:16:05,130 --> 00:16:09,370
+إلى الاستماع. أما في مراحل الطفولة المتوسطة، خاصة في
+
+155
+00:16:09,370 --> 00:16:14,330
+نهاياتها، والطفولة المتأخرة، يستطيع الطفل أن يعتمد
+
+156
+00:16:14,330 --> 00:16:19,890
+على نفسه في القراءة، وبالتالي قد يستعين بكبار السن
+
+157
+00:16:19,890 --> 00:16:29,220
+والآخرين. عن ذلك نجد هنا، عندما نقول أدب الطفل هنا،
+
+158
+00:16:29,220 --> 00:16:33,900
+نأتي إلى المفهوم، كلام جيد، لابد أن يحدث في نفس
+
+159
+00:16:33,900 --> 00:16:41,780
+الأطفال متعة فنية، وهذه المتعة الفنية تشكل عنصرًا أو
+
+160
+00:16:41,780 --> 00:16:46,620
+عنصرًا من عناصر الجذب بالنسبة
+
+161
+00:16:46,620 --> 00:16:52,760
+للطفل. إذن كلام جيد، وهذا الكلام الجيد يمكن أن يكون شعرًا
+
+162
+00:16:52,760 --> 00:16:58,500
+أو نثرًا، يتسم بالجمال. هذا الكلام الجيد والجميل يحمل
+
+163
+00:16:58,500 --> 00:17:06,960
+في داخله قيمًا ترفيهية وقيمًا علمية، قيمًا ترفيهية وقيمًا
+
+164
+00:17:06,960 --> 00:17:18,660
+علمية. بالإضافة إلى ذلك، نجد أن أدب الطفل لابد أن يتسم
+
+165
+00:17:20,060 --> 00:17:24,980
+بخصائص. إذن المفهوم واضح، مفهوم أدب الطفل بالنسبة
+
+166
+00:17:24,980 --> 00:17:31,200
+للكبار والصغار ليس واحدًا، وإنما هناك نقاط التقاء
+
+167
+00:17:31,200 --> 00:17:35,580
+بينهما. لا نستطيع أن نقول إن مفهوم أدب الطفل يختلف
+
+168
+00:17:35,580 --> 00:17:40,100
+اختلافًا كليًا عن أدب الكبار، أو أدب الأطفال، لا، هناك
+
+169
+00:17:40,100 --> 00:17:44,320
+التقاء في المفهوم، ولكن هذا التقاء في جوانب، واختلاف
+
+170
+00:17:44,320 --> 00:17:51,010
+في جوانب أخرى. لذلك لابد، إذن أدب الطفل، مع
+
+223
+00:22:50,320 --> 00:22:56,570
+معنى ذلك، المعرفة إذاً بالأطفال .. معرفة الأطفال بالأدب
+
+224
+00:22:56,570 --> 00:23:03,950
+تتدرج، واستعدادات الطفل لتقبل الأدب تتغير حسب طبيعة
+
+225
+00:23:03,950 --> 00:23:08,590
+فكره وخياله، وبالتالي لا نستطيع أن نقول أن الطفل
+
+226
+00:23:08,590 --> 00:23:15,970
+يبقى ثابتًا .. يبقى ثابتًا في استقباله للأدب، لأن
+
+227
+00:23:15,970 --> 00:23:19,370
+نقول يتغير، وبالتالي ما يعجب .. ما يعجب به الأطفال
+
+228
+00:23:19,370 --> 00:23:24,650
+في مرحلة طفولة مبكرة لا يعجبهم في مرحلة طفولة
+
+229
+00:23:24,650 --> 00:23:29,690
+متوسطة، وما يعجبهم في مرحلة طفولة متوسطة لا يعجبهم
+
+230
+00:23:29,690 --> 00:23:34,010
+في مرحلة طفولة متأخرة، ما السبب في ذلك؟ النمو العقلي
+
+231
+00:23:34,010 --> 00:23:38,450
+والنفسي والخيالي والإدراكي والحسي للأطفال بل
+
+232
+00:23:38,450 --> 00:23:43,770
+لاحظوا، إحنا في بعض الأحيان أطفالنا يستمعون ويشاهدون
+
+233
+00:23:43,770 --> 00:23:47,170
+فضائية أطفال، "أطيور الجنة"
+
+234
+00:23:50,960 --> 00:23:57,400
+يصرون على الاستماع والمشاهدة، ولكن عندما ينمو الطفل
+
+235
+00:23:57,400 --> 00:24:00,480
+في مرحلة طفولة متوسطة، نجد أن هذا الاهتمام يقل
+
+236
+00:24:00,480 --> 00:24:05,580
+ويتجه هذا الاهتمام نحو شيء، أدب أو نوع من أنواع
+
+237
+00:24:05,580 --> 00:24:10,700
+الأدب الأخرى، وبالتالي كلما ازداد النمو لدى الأطفال
+
+238
+00:24:11,280 --> 00:24:14,660
+سواء كان نمو فكريًا أو خياليًا أو معرفيًا أو إدراكيًا أو
+
+239
+00:24:14,660 --> 00:24:18,660
+حسيًا، لابد أن يعكس ذلك على اختيارهم للوسائل
+
+240
+00:24:18,660 --> 00:24:25,520
+التعبيرية التي يستخدمها الأدب في ذلك، وأدب الطفل
+
+241
+00:24:25,520 --> 00:24:32,000
+لا يعرف الثبات، وبالتالي لابد أن يمتد إلى ما وراء
+
+242
+00:24:32,000 --> 00:24:40,540
+حدود الواقع، وهذا يحدث في الطفولة المتأخرة خاصةً، أدب
+
+243
+00:24:40,540 --> 00:24:45,620
+الطفل من خصائصه، لابد أن يعكس ويواكب تطورات الحياة
+
+244
+00:24:45,620 --> 00:24:51,640
+ومن خصائص أدب الطفل أيضًا، لابد أن يحقق الاستجابة
+
+245
+00:24:51,640 --> 00:24:56,020
+والإثارة للأطفال، لابد أن يجلب انتباه الطفل، لابد أن
+
+246
+00:24:56,020 --> 00:25:03,020
+يشعر الطفل اتجاهه بالقبول والمحبة في هذا الجانب
+
+247
+00:25:03,020 --> 00:25:10,280
+لذلك نجد هنا أن من خلال هذه المحاضرة تحدثنا عن
+
+248
+00:25:10,280 --> 00:25:15,940
+أهمية أدب الطفل، يعني معنى ذلك، لابد لمن يكتب
+
+249
+00:25:15,940 --> 00:25:21,500
+للأطفال أو يدرس مساق أدب الأطفال هنا أن يعرف أهمية
+
+250
+00:25:21,500 --> 00:25:29,500
+الأدب بالنسبة للطفل، لأن أدب الأطفال يتمتع بخصائص
+
+251
+00:25:29,500 --> 00:25:36,450
+لابد أن تنسجم مع طبيعة النمو الفكري والعقلي و
+
+252
+00:25:36,450 --> 00:25:39,190
+الإدراكي والحسي عند الطفل، لابد أن تنسجم مع
+
+253
+00:25:39,190 --> 00:25:44,070
+مستويات الطفولة التي هناخدها فيما بعد، الطفولة
+
+254
+00:25:44,070 --> 00:25:51,710
+المبكرة والطفولة المتوسطة والطفولة المتأخرة، لذلك
+
+255
+00:25:51,710 --> 00:26:01,970
+نجد هنا أن أدب الطفل لابد أن يتضح مفهومه وخصائصه
+
+256
+00:26:01,970 --> 00:26:11,280
+وأهميته، وبالتالي، في المحاضرة القادمة سنبدأ الحديث
+
+257
+00:26:11,280 --> 00:26:18,940
+عن مراحل الطفولة، بمعنى أن أدب ومراحل الطفولة
+
+258
+00:26:18,940 --> 00:26:22,640
+سنبدأ إن شاء الله تعالى في مراحل الطفولة الأولى
+
+259
+00:26:22,640 --> 00:26:28,740
+التي تسمى مرحلة الطفولة من 1 إلى 3 سنوات، وبعد
+
+260
+00:26:28,740 --> 00:26:33,500
+ذلك إن شاء الله تعالى، مرحلة الطفولة الثانية المبكرة
+
+261
+00:26:33,500 --> 00:26:37,220
+الثانية، في مبكرة أولى ومبكرة ثانية، نأخذ أنها ثانية
+
+262
+00:26:37,220 --> 00:26:41,220
+كذلك و نركز عليها، وبالتالي محاضرتنا إن شاء الله
+
+263
+00:26:41,220 --> 00:26:46,700
+تعالى ستتم التركيز على أولى مراحل الطفولة، وهي
+
+264
+00:26:46,700 --> 00:26:51,140
+مرحلة الطفولة الأولى من سنة إلى ثلاث سنوات
+
+265
+00:26:51,140 --> 00:26:55,180
+ثم ننتقل بعد ذلك إلى مرحلة الطفولة المبكرة، للطفولة
+
+266
+00:26:55,180 --> 00:27:00,540
+الثانية من ثلاث إلى ست سنوات، مرة ثانية أؤكد أن
+
+267
+00:27:00,540 --> 00:27:04,720
+الكتاب المقرر علينا هو نص الأدبي للأطفال، الذي هنا
+
+268
+00:27:04,720 --> 00:27:10,620
+أهدافه، مصادره، سماته، للدكتور سعد
+
+269
+00:27:10,620 --> 00:27:15,640
+أبو أرض، وإن شاء الله تعالى في محاضرة قادمة سنحدد
+
+270
+00:27:15,640 --> 00:27:19,440
+كيفية توزيع الدرجات، ونبدأ إن شاء الله تعالى في
+
+271
+00:27:19,440 --> 00:27:24,280
+تحديد التكاليف المطلوبة بالنسبة لكل طالب أو طالبة
+
+272
+00:27:24,280 --> 00:27:28,860
+في هذا المجال، أرجو في المحاضرة القادمة الاستعداد
+
+273
+00:27:28,860 --> 00:27:34,230
+والتحضير لما يتعلق بمراحل الطفولة، سنبدأ في المرحلة
+
+274
+00:27:34,230 --> 00:27:38,770
+الأولى، الطفولة الأولى، ما يتعلق بالطفولة
+
+275
+00:27:38,770 --> 00:27:43,950
+الأولى، ثم بعد ذلك الطفولة الثانية، ونبدأ بعد ذلك
+
+276
+00:27:43,950 --> 00:27:50,030
+في المراحل الأخرى، وكما قلت سابقًا، أنه سيكون هناك
+
+277
+00:27:50,030 --> 00:27:56,750
+جانب تطبيقي واسع، المساق يعتمد على جانب نظري، ونظري
+
+278
+00:27:56,750 --> 00:27:59,310
+وهو، حيث سيكون في البداية إن شاء الله تعالى، وبعد
+
+279
+00:27:59,310 --> 00:28:06,750
+ذلك سيكون لدينا نصوص مسرحية وقصصية وشعرية، يتم من
+
+280
+00:28:06,750 --> 00:28:11,230
+خلالها، وإن شاء الله، يتم من خلالها فهم الجانب التطبيقي
+
+281
+00:28:11,230 --> 00:28:15,830
+ومزج الجانب النظري بالجانب التطبيقي، هذا والله
+
+282
+00:28:15,830 --> 00:28:20,890
+التوفيق، والسلام عليكم ورحمة الله وبركاته
diff --git a/PL9fwy3NUQKwYT4Ayhm-3qTiT1ILbX-hwD/rR7QicwJyV8_postprocess.srt b/PL9fwy3NUQKwYT4Ayhm-3qTiT1ILbX-hwD/rR7QicwJyV8_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..49e3cf28521eba1f0fdf31f102d1aef64b6de7fb
--- /dev/null
+++ b/PL9fwy3NUQKwYT4Ayhm-3qTiT1ILbX-hwD/rR7QicwJyV8_postprocess.srt
@@ -0,0 +1,1128 @@
+1
+00:00:00,960 --> 00:00:05,480
+بسم الله الرحمن الرحيم هذه المحاضرة التانية محاضرة
+
+2
+00:00:05,480 --> 00:00:12,980
+أدب الأطفال الكتاب المقرر علينا في هذا المثاق هو
+
+3
+00:00:12,980 --> 00:00:18,000
+النص الأدبي للأطفال من تأليف سعد أبو الرضاأحنا
+
+4
+00:00:18,000 --> 00:00:21,880
+خدنا في المحاضرة الأولى حديث عن الأدب والثقافة
+
+5
+00:00:21,880 --> 00:00:29,000
+فتحدثنا عن مفهوم الأدب و التطور الدلالي لمفرط
+
+6
+00:00:29,000 --> 00:00:34,520
+الأدب ما بين الجانب الحسي المادي والجانب المعنوي
+
+7
+00:00:34,520 --> 00:00:39,280
+ثم بعد ذلك تحدثنا عن الثقافة و علاقة الثقافة
+
+8
+00:00:39,280 --> 00:00:44,780
+بالأدب و كيف يمكن للأدب أن يعبر على الثقافة ثم بعد
+
+9
+00:00:44,780 --> 00:00:51,230
+ذلك اتقلنا للحديثعن التجسيد التجسيد الفني للأدب
+
+10
+00:00:51,230 --> 00:00:57,550
+وأهمية هذا التجسيد الفني للأدب وانعكسات هذا
+
+11
+00:00:57,550 --> 00:01:02,050
+التجسيد على الأدب على الطفل محيط استقبال الأدب
+
+12
+00:01:02,050 --> 00:01:07,250
+وأدب الأطفال وكيف يهيئ التجسيد الفني للطفل
+
+13
+00:01:07,250 --> 00:01:12,830
+لاستقبال الأدبهذه المحاضرة اللي هي المحاضرة
+
+14
+00:01:12,830 --> 00:01:16,090
+التانية موجودة في الكتاب تحت عنوان أهمية أدب
+
+15
+00:01:16,090 --> 00:01:20,730
+الأطفال الإسلامي أهمية
+
+16
+00:01:20,730 --> 00:01:28,290
+أدب الأطفال الإسلامي تكمن هنا أهمية الأدب بالنسبة
+
+17
+00:01:28,290 --> 00:01:34,130
+للطفل قبل أن نعرف هذه الأهمية لابد أن نتعرف على
+
+18
+00:01:34,130 --> 00:01:40,810
+احتياجاتالأطفال على اهتمامات الأطفال على مشكلات
+
+19
+00:01:40,810 --> 00:01:49,390
+الأطفال لابد لمن يدرس أو يكتب للطفل أن يعرف مشكلات
+
+20
+00:01:49,390 --> 00:01:52,390
+الأطفال لابد أن يتعرف كذلك ويقدم لهم الحلول لهذه
+
+21
+00:01:52,390 --> 00:02:00,030
+المشكلات ومن هنا يستخدم الأدب في
+
+22
+00:02:00,030 --> 00:02:06,440
+زرع القيم والمبادئ والمثل للأطفالو من هنا نستطيع
+
+23
+00:02:06,440 --> 00:02:13,360
+أن نقول أن أدب الأطفال يستخدم وسيلة حضارية إنسانية
+
+24
+00:02:13,360 --> 00:02:18,820
+فكرية علمية إلى آخره من أجل إرسال هذه القيم وسيلة
+
+25
+00:02:18,820 --> 00:02:27,340
+إذا الطفل اليوم هو رجل المستقبل و لابد هنا أن
+
+26
+00:02:27,340 --> 00:02:33,530
+نبلور شخصية هذا الطفل عن طريق الأدببكل فنون
+
+27
+00:02:33,530 --> 00:02:38,490
+المتنوعة سواء كان قصة أو مسرحية أو نشيد أو غير ذلك
+
+28
+00:02:38,490 --> 00:02:45,770
+إذا هناك وسائل ينقل من خلال الأدب أو يتوظف من خلال
+
+29
+00:02:45,770 --> 00:02:50,670
+الأدب من أجل التأثير في الأطفال وجذب انتباه
+
+30
+00:02:50,670 --> 00:02:55,130
+الأطفال من أجل غرس القيم والمبادئ والأفكار
+
+31
+00:02:55,130 --> 00:03:02,430
+المتنوعة التي يريد الأب أو المعلمأن يرسخها في وجود
+
+32
+00:03:02,430 --> 00:03:07,090
+الأطفال إذا لابد للأدب أن يشبع اهتمام اهتمامات
+
+33
+00:03:07,090 --> 00:03:12,310
+الطفل لابد للأدب أن يلبح احتياجات ورغبات الطفل
+
+34
+00:03:12,310 --> 00:03:17,770
+لابد للأدب أن يقدم للطفل غذاء نفسي وفكري وغذاء
+
+35
+00:03:17,770 --> 00:03:24,670
+معنوي لابد للأدب أن يرقاه بالأطفال
+
+36
+00:03:25,700 --> 00:03:30,000
+على مستوى الفكري على مستوى الخيال على مستوى النمو
+
+37
+00:03:30,000 --> 00:03:35,640
+الحسي لذلك هنا لابد أن يقدم الأدب للطفل معلومات
+
+38
+00:03:35,640 --> 00:03:44,160
+علمية فنية جمالية دينية تاريخية قومية أي الأخرى
+
+39
+00:03:44,160 --> 00:03:48,760
+كذلك لابد للأدب أن يتوافق مع استعدادات الطفل
+
+40
+00:03:48,760 --> 00:03:56,490
+وميوله نحو اللعب وبالتالي الأدبيكون وسيلة ترفيهية
+
+41
+00:03:56,490 --> 00:04:04,550
+ووسيلة تعليمية للأطفال لابد أن يكتشف الطفل من خلال
+
+42
+00:04:04,550 --> 00:04:11,190
+أدب أشياء جديدة ويترك للطفل حرية الاختيار للأنواع
+
+43
+00:04:11,190 --> 00:04:17,690
+الأدبية التي ينسجم معها وتحقق احتياجاته وتلبي
+
+44
+00:04:17,690 --> 00:04:29,040
+رغباته كذلك لابد أن يتحولالطفل في معرفته للأدب من
+
+45
+00:04:29,040 --> 00:04:37,800
+الجانب الترفيهي إلى الجانب التعليمي ومن هنا تحدث
+
+46
+00:04:37,800 --> 00:04:45,760
+مشاركة وجدانية عقلية خيالية نفسية بين فنون الأدب
+
+47
+00:04:45,760 --> 00:04:53,300
+وبين الطفل وبالتالي تتحقق إشباع اهتمامات
+
+48
+00:04:55,280 --> 00:05:00,680
+ورغبات الطفل لذلك
+
+49
+00:05:00,680 --> 00:05:07,220
+نقول أن الطفل بحاجة إلى أدب خاصة في السنوات الأولى
+
+50
+00:05:07,220 --> 00:05:13,020
+السنوات التكوينية التي تبلور شخصية الطفل لذلك تكمن
+
+51
+00:05:13,020 --> 00:05:21,520
+أهمية أدب الأطفال في نقل المعرفة إلى الطفل ونقل
+
+52
+00:05:21,520 --> 00:05:27,420
+التجارب البشريةأدب الطفل يزيد الثروة اللغوية عند
+
+53
+00:05:27,420 --> 00:05:32,280
+الأطفال أدب الطفل ينمي الإحساس للأطفال بجمال
+
+54
+00:05:32,280 --> 00:05:38,740
+الكلمات وإيقاع الكلمات وكذلك يشعر الطفل بالقوة
+
+55
+00:05:38,740 --> 00:05:43,420
+التأثيرية لهذه الإيقاعات لذلك هنا نجد أن الطفل
+
+56
+00:05:43,420 --> 00:05:48,310
+يستطيع من خلال الأدب أن يحقق رغبات متعددةفيكون من
+
+57
+00:05:48,310 --> 00:05:52,470
+خلال الأدب أكتر قابولة للحياة و أكتر تفهما
+
+58
+00:05:52,470 --> 00:06:00,810
+لمتغيرات الحياة كذلك أكتر تكيفا مع احتجاجات الحياة
+
+59
+00:06:00,810 --> 00:06:06,570
+وبالتالي يستطيع الأدب أن يربط ما بين الواقع المعاش
+
+60
+00:06:06,570 --> 00:06:12,900
+والماضي ويؤدي الدور المستقبليومن هنا نقول أن الأدب
+
+61
+00:06:12,900 --> 00:06:20,580
+له دور مهم في غرز القيم الدينية والمبادئ الأخلاقية
+
+62
+00:06:20,580 --> 00:06:28,200
+الإسلامية التي تعزز بناء شخصية الطفل لذلك نجد هناك
+
+63
+00:06:28,200 --> 00:06:34,680
+علاقة وثيقة ما بين الكلمة والمعتقد والعقيدة
+
+64
+00:06:34,680 --> 00:06:38,760
+الإسلامية وبالتالي
+
+65
+00:06:38,760 --> 00:06:45,660
+يتجاوز الأدبكونه وسيلة ترفيهية إلى وسيلة تعليمية
+
+66
+00:06:45,660 --> 00:06:49,900
+البداية الأدب تكون وسيلة ترفيهية ثم مع النمو و
+
+67
+00:06:49,900 --> 00:06:54,540
+التطور الذي يحدث للطفل يتحول من الوسيلة الترفيهية
+
+68
+00:06:54,540 --> 00:07:04,460
+إلى وسيلة تعليمية فنلاحظ أن الأدب يجسد جانب وجداني
+
+69
+00:07:04,460 --> 00:07:10,940
+يعزز جانب التعاون مع باقي الأطفال يدعم
+
+70
+00:07:12,960 --> 00:07:21,360
+التواصل بين الأطفال يشكل وجدان الأطفال يسقل مشاعر
+
+71
+00:07:21,360 --> 00:07:26,780
+الأطفال يعزز تنشأ السوية السليمة لديهم يعزز قيم
+
+72
+00:07:26,780 --> 00:07:33,260
+الحق والخير والجمال للأطفال لذلك هنا نجد أن أدب
+
+73
+00:07:33,260 --> 00:07:38,560
+الأطفال أدب الأطفال يجب أن ينهض بما يدعو إليه
+
+74
+00:07:38,560 --> 00:07:42,830
+الإسلامبمعنى أن أدب الطفل لابد أن يحمل في داخله
+
+75
+00:07:42,830 --> 00:07:49,950
+رسالة وهذه الرسالة تعزز القيم الإسلامية والمبادئ
+
+76
+00:07:49,950 --> 00:07:55,570
+الدينية لديه بحب العلم والسعادة في رضا الله والقيم
+
+77
+00:07:55,570 --> 00:07:59,590
+الدينية متعلقة بالصدق والإخلاص والأمانة والمحبة
+
+78
+00:07:59,590 --> 00:08:04,610
+وغير ذلك إضافة إلى ذلك أن أدب الطفل ينمي الخيال
+
+79
+00:08:04,610 --> 00:08:08,790
+للأطفال ويطلق لديهم التفكير
+
+80
+00:08:11,310 --> 00:08:17,110
+في أشياء متعددة ومتنوعة وبالتالي نستطيع أن نقول أن
+
+81
+00:08:17,110 --> 00:08:22,770
+أدب الطفل يسهم إسهاما كبيرا في تحقيق الاستقرار
+
+82
+00:08:22,770 --> 00:08:30,210
+والتوازن النفسي لدى الأطفال إضافة إلى ذلك نقول أن
+
+83
+00:08:30,210 --> 00:08:38,810
+أهمية أدب الطفل تقمن في أنه يساعد على بناء الشخصية
+
+84
+00:08:38,810 --> 00:08:45,510
+للطفليساعد على بناء الطفل من ناحية نفسية ومن ناحية
+
+85
+00:08:45,510 --> 00:08:52,210
+عقلية وخيالية مراعية الخصائص لأن كل مراحل من مراحل
+
+86
+00:08:52,210 --> 00:08:59,350
+الطفولة لها ما يناسبها من الأدب فلذلك الأدب يقدم
+
+87
+00:08:59,350 --> 00:09:05,530
+للأطفال معيارا أخلاقيا، دينيا، اجتماعيا، معيارا
+
+88
+00:09:05,530 --> 00:09:13,210
+ترفيهيالذلك لا يمكن أن ينفصل المعيار الأخلاقي أو
+
+89
+00:09:13,210 --> 00:09:18,310
+الديني أو الموضوعي عن المعيار الفني لذلك نستطيع أن
+
+90
+00:09:18,310 --> 00:09:22,890
+نقول أن أدب الطفل في داخله بنية متراكبة لا يمكن أن
+
+91
+00:09:22,890 --> 00:09:31,850
+ينفصل فيها الشكل عن المضمون فكلاهما يعزز وجود
+
+92
+00:09:31,850 --> 00:09:37,310
+الآخر لأن الأدب تعبير عن الحضارة الإنسانيةومن هنا
+
+93
+00:09:37,310 --> 00:09:45,610
+نقول الطفل بحاجة إلى أن يتعرف على ذاته يتعرف على
+
+94
+00:09:45,610 --> 00:09:50,310
+البيئة المحيطة به كيف يمكن أن يتعرف على ذاته أو
+
+95
+00:09:50,310 --> 00:09:54,770
+يتعرف على البيئة المحيطة به الأدب أدب الأطفال بكل
+
+96
+00:09:54,770 --> 00:09:59,950
+أنواعه الأدبية سواء كان شعر أو نفع يسهم إسهاما
+
+97
+00:09:59,950 --> 00:10:06,070
+كبيرا في تهيئة الفرصة اللازمةأمام الطفل للتعرف على
+
+98
+00:10:06,070 --> 00:10:12,010
+ذاته وعلى البيئة المحيطة به حيث
+
+99
+00:10:12,010 --> 00:10:19,770
+يقدم مجموع من الخبرات للأطفال لذلك أدب الطفل يسهم
+
+100
+00:10:19,770 --> 00:10:25,570
+في صياغة عقل الطفل وتنمية الخيال إليه أدب الطفل من
+
+101
+00:10:25,570 --> 00:10:33,610
+أهميته ومكانته البناءة ينمي الإحساس للأطفال يزيد
+
+102
+00:10:34,250 --> 00:10:41,310
+وعي الطفل لفهم الواقع المعاش ووعيه بالماضي
+
+103
+00:10:41,310 --> 00:10:46,990
+واستشرافي لأفاق المستقبل لذلك أدب الطفل يعد وسيطا
+
+104
+00:10:46,990 --> 00:10:53,450
+تربويا يتيح الفرصة أمام الأطفال لمعرفة كثير من
+
+105
+00:10:53,450 --> 00:10:56,750
+الأسئلة لمعرفة كثير من الإجابات عن الأسئلة
+
+106
+00:10:56,750 --> 00:11:03,000
+والاستفسارات التي تدور في ألهانهمأدب الطفل يعتبر
+
+107
+00:11:03,000 --> 00:11:07,880
+وسيطا تربويا يتيح الفرصة أمام الأطفال لمعرفة
+
+108
+00:11:07,880 --> 00:11:13,480
+الإجابات عن كثير من الأسئلة والاستفسارات ومحاولات
+
+109
+00:11:13,480 --> 00:11:18,980
+الكشف والتعرف على الأشياء من حولهم لذلك أدب الطفل
+
+110
+00:11:18,980 --> 00:11:25,600
+أيضا ينقل للأطفال الخبرات سواء الماضي أو في الواقع
+
+111
+00:11:25,600 --> 00:11:33,230
+المعاشر أدب الأطفاليتيح الفرصة أمام الطفل لتحقيق
+
+112
+00:11:33,230 --> 00:11:41,670
+الثقة بالنفس من خلال ثقل شخصي الطفل التي يعمل أدب
+
+113
+00:11:41,670 --> 00:11:46,590
+على أن يشارك الطفل في الأعمال الجماعية كالمسرحيات
+
+114
+00:11:46,590 --> 00:11:53,070
+والتمثيل والأناشيد تكون أعمال جماعية وليست فردية
+
+115
+00:11:53,070 --> 00:11:59,170
+فيعزز دي فرصة الاحتكاكبالاخرين وهنا تقمن أو يعزز
+
+116
+00:11:59,170 --> 00:12:09,750
+الثقة بالنفس كذلك نجد أن أدب الطفل يمكن الأطفال من
+
+117
+00:12:09,750 --> 00:12:20,110
+التحرر من العادات والتقاليد السيئة ويرسخ لديهم
+
+118
+00:12:20,110 --> 00:12:29,250
+الخبرة والقيم البناءةالخبرات والقيم البناء يوفر
+
+119
+00:12:29,250 --> 00:12:36,910
+للأطفال أسباب الترويح والترفيه عن أنفسهم ويوفر لهم
+
+120
+00:12:36,910 --> 00:12:44,930
+القيم العلمية والدينية والتربوية وما يتعلق بالبيئة
+
+121
+00:12:44,930 --> 00:12:50,430
+المحيطة بهم لذلك نجد في أدب الطفل جوانب تاريخية
+
+122
+00:12:50,430 --> 00:12:58,120
+تزويد الطفل بما يتعلق بثقافة الماضي نجد في أدب
+
+123
+00:12:58,120 --> 00:13:05,380
+الطفل نواحي دينية و هي قصص الدينية نلاحظ أنها
+
+124
+00:13:05,380 --> 00:13:11,080
+كنواحي قومية الأحداث والشخصيات التي تسهم في بناء
+
+125
+00:13:11,080 --> 00:13:16,500
+التاريخكذلك نجد هناك نواحي ثقافية تزوّل الأطفال
+
+126
+00:13:16,500 --> 00:13:19,440
+بالمعلومات المختلفة عن الثقاف و عن الحضارات و عن
+
+127
+00:13:19,440 --> 00:13:26,200
+التقاليد و عن الأمم المختلفة و الشعوب الأخرى في
+
+128
+00:13:26,200 --> 00:13:30,660
+نواحي عقلية يزوّل الأدب الطفل بالنواحي عقليةينمي
+
+129
+00:13:30,660 --> 00:13:38,080
+لديهم فهم العلم والتطور التكنولوجي والحضارة يعزز
+
+130
+00:13:38,080 --> 00:13:43,180
+لديهم فهم طبيعة المقترعات الحديثة الإلكترونية كذلك
+
+131
+00:13:43,180 --> 00:13:50,580
+يعزز لديهم نواحي أخلاقية التعلق بمحاكاة الأنبياء
+
+132
+00:13:50,580 --> 00:13:55,000
+والرسل والصحابة والتابعين والشخصيات المتنوعة يعزز
+
+133
+00:13:55,000 --> 00:13:59,400
+لديهم كذلك أدب الأطفال جوانب النواحي الترويحية
+
+134
+00:13:59,400 --> 00:14:06,650
+والنفسيةالطفل يجد هناك جوانب ترفيه هي يتسلق من
+
+135
+00:14:06,650 --> 00:14:14,570
+خلال .. يتسلق و يروح عن .. و يرفع عن نفسه من خلال
+
+136
+00:14:14,570 --> 00:14:20,590
+الاسماع أو القراءة في أدب الأطفال هذه ما هو ما
+
+137
+00:14:20,590 --> 00:14:27,730
+يتعلق بأدب أو أهمية أدب الطفل
+
+138
+00:14:30,900 --> 00:14:36,300
+نأتي إلى الجزء الآخر من هذه المحاضرة فيما يتعلق
+
+139
+00:14:36,300 --> 00:14:43,160
+بأذب الأطفال نبدأ بالمفهوم إذا كان أذب الأطفال
+
+140
+00:14:43,160 --> 00:14:48,040
+بمعناه العام بمعنى العام ماذا يقصد به؟ إنتاج عقلي
+
+141
+00:14:48,040 --> 00:14:51,200
+مدون
+
+142
+00:14:51,200 --> 00:14:57,700
+في الكتب وموجه لمن؟ للأطفال هذا بمعناه العام يعني
+
+143
+00:14:57,700 --> 00:15:03,050
+إنتاج عقلي يكتبه الكبارفي كتب ويتم توجيه هذه
+
+144
+00:15:03,050 --> 00:15:06,770
+الكتابات إلى الأطفال سواء في المقارات الدراسية
+
+145
+00:15:06,770 --> 00:15:11,690
+القراءة الإلزامية التعليمية أو في القراءة الحرة
+
+146
+00:15:11,690 --> 00:15:21,370
+ومن هنا بالمعنى العام أما المعنى الخاص نقول أن أدب
+
+147
+00:15:21,370 --> 00:15:27,430
+الطفل هو الكلام الجيد الجميل كلام جيد وجميل يجد
+
+148
+00:15:27,430 --> 00:15:33,080
+باهتمام الطفلوماذا ويحدث في نفسهم أيضًا متعة فنية
+
+149
+00:15:33,080 --> 00:15:43,420
+ويثري فكر الأطفال وهذا الأدب سواء كان أدبًا شفويا
+
+150
+00:15:43,420 --> 00:15:51,160
+مشفوعا بالكلام أو أدبًا تحريريا بالكتابة وهذا
+
+151
+00:15:51,160 --> 00:15:56,910
+الأدب ما يتعلق بالجانب الشفوي أو التحريرييختلف حسب
+
+152
+00:15:56,910 --> 00:16:00,850
+اللي هو مراحل نمو الطفل لأن في مرحل من مراحل لا
+
+153
+00:16:00,850 --> 00:16:05,130
+يستطيع الطفل أن يعتمد على نفسه في القراءة فيلجأ
+
+154
+00:16:05,130 --> 00:16:09,370
+إلى الاستماع أما في مراحل الطفولة المتوسطة خاصة في
+
+155
+00:16:09,370 --> 00:16:14,330
+نهاياتها والطفولة المتأخرة يستطيع الطفل أن يعتمد
+
+156
+00:16:14,330 --> 00:16:19,890
+على نفسه في القراءة وبالتالي قد يستعين بكبار السن
+
+157
+00:16:19,890 --> 00:16:29,220
+والآخرينعن ذلك نجد هنا عندما نقول أدب الطفل هنا
+
+158
+00:16:29,220 --> 00:16:33,900
+نأتي إلى المفهوم كلام جيد لابد أن يحدث في نفس
+
+159
+00:16:33,900 --> 00:16:41,780
+الأطفال متعة فنية وهذه متعة فنية تشكل عنصرا أو
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+160
+00:16:41,780 --> 00:16:46,620
+عنصر من عناصر الجدب بالنسبة
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+161
+00:16:46,620 --> 00:16:52,760
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+162
+00:16:52,760 --> 00:16:58,500
+أو نفرا يتسم بالجمال هذا الكلام الجيد والجميل يحمل
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+163
+00:16:58,500 --> 00:17:06,960
+في داخله قيم ترفيهية وقيم علمية قيم ترفيهية وقيم
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+164
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+علمية إضافة إلى ذلك نجد أن أدب الطفل لابد أن يتسم
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+165
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+بخصائص إذا المفهوم واضح مفهوم أدب الطفل بالنسبة
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+166
+00:17:24,980 --> 00:17:31,200
+للكبار والصغار ليس واحدا وإنما هناك نقاط التقاء
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+167
+00:17:31,200 --> 00:17:35,580
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+168
+00:17:35,580 --> 00:17:40,100
+اختلافا كليا عن أدب الكبار أو الأطفال لأ هناك
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+169
+00:17:40,100 --> 00:17:44,320
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+00:17:44,320 --> 00:17:51,010
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+171
+00:17:51,010 --> 00:17:56,530
+مفهومه الإنتاج العقلي المدون في كتب موجهة لمين
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+172
+00:17:56,530 --> 00:18:01,650
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+173
+00:18:01,650 --> 00:18:05,670
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+174
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+175
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+يختار روح المكتبة ويختار كتب خاصة بالأطفال هذا
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+176
+00:18:15,130 --> 00:18:20,020
+المعنى العام أما المعنى الخاصالكلام الجميل كلام
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+177
+00:18:20,020 --> 00:18:25,620
+الجيد الجميل لاحظوا كلمة جيد و الجميل onesogenic و
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+178
+00:18:25,620 --> 00:18:31,620
+الكلام مسموع و قد يكون مقرؤ و قد يكون مرئي من خلال
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+179
+00:18:31,620 --> 00:18:36,420
+التمثيل وهنا يبين أن أساس أذب الطفل يعتمد على
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+180
+00:18:36,420 --> 00:18:41,920
+الكلمة المموثقة خاصة في مراحة الطفولة المبكرة أو
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+181
+00:18:41,920 --> 00:18:48,550
+نهايات مراحة المهديحدث في نفوس الأطفال متعة ثنية
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+182
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+في متعة ينجذب الطفل ويشعر بالراحة النفسية إلى جانب
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+183
+00:18:53,150 --> 00:18:59,610
+المتعة الفنية هناك إثراء للفكر أدب الطفل لابد أن
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+184
+00:18:59,610 --> 00:19:05,290
+يكون مشهورا بالكلام هنا مشهورا بالكلام إما أن يكون
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+185
+00:19:05,290 --> 00:19:09,710
+عبارة عن أناشيد أو أغاني أو مسرحيات أو قصص مختلفة
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+186
+00:19:11,870 --> 00:19:20,570
+أدب الطفل من خصائصه لابد أن يكون مناسبا للصغار لأن
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+187
+00:19:20,570 --> 00:19:24,610
+أدب الكبار يختلف عن أدب الصغار إذا كنا مناسبا طب
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+188
+00:19:24,610 --> 00:19:30,610
+ما نوع هذا التناسب هو التناسب الأخلاقي لابد أنه
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+189
+00:19:30,610 --> 00:19:38,890
+حافظ على أخلاق الطفل الأطفال لابد أن لا يفسد الأدب
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+190
+00:19:38,890 --> 00:19:43,550
+الجانب الأخلاقيوالقيمة عند الأطفال هذا الأول إذا
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+191
+00:19:43,550 --> 00:19:47,090
+التناسب و أخلاق التناسب الثاني تناسب تعليمي في
+
+192
+00:19:47,090 --> 00:19:51,650
+مقام التعليم أي ينبغي على أدب الطفل اللي يتجاوز
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+193
+00:19:51,650 --> 00:19:57,370
+مستوى العقلي و الإدراك عند الأطفال إذا أدب الطفل
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+194
+00:19:57,370 --> 00:20:02,230
+الإسلامي من خصائصه أنه يتخذ أو أدب الطفل بشكل عام
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+195
+00:20:02,230 --> 00:20:08,930
+يتخذ الكلمة وسيلة تعبيرالجميل وهذا إذا اتخذ الكلمة
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+196
+00:20:08,930 --> 00:20:13,650
+الجميلة وسيلة التعبير يتحقق في ذلك أو من خلال هذه
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+197
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+الاستخدام أشياء متعددة يرسخ العقيدة يديهم يثر
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+198
+00:20:17,450 --> 00:20:25,650
+الفكر يشعرون اتجاهه بالمتعة الوجدانية إذا المعنى
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+199
+00:20:25,650 --> 00:20:32,070
+ذلك أدب الطفل يتجاوز أدب الأطفال يتجاوز المفهوم
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+200
+00:20:32,840 --> 00:20:36,320
+التقليد بأن الكلمة هي المادة الأساسية إلى وسائل
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+201
+00:20:36,320 --> 00:20:43,660
+متعدلة يعني يتخذ أدب الطفل وسائل التي يتخذها من
+
+202
+00:20:43,660 --> 00:20:49,060
+أجل أو يعتمدها في إصال المعرفة للطفل نقول قد يأخذ
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+203
+00:20:49,060 --> 00:20:54,040
+الكلمة أو النغمة أو يكون الرسم أو الصورة المتحركة
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+204
+00:20:54,040 --> 00:21:00,780
+أو الصامتةإذا المعنى ذلك أن وسائل الأدب الوسائل
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+205
+00:21:00,780 --> 00:21:06,360
+التي تقدم الأدب للأطفال متنوعة قد يقدم الأدب للطفل
+
+206
+00:21:06,360 --> 00:21:12,220
+عن طريق كلمة يسمعها أو يقرأها أو النغمة عن طريق
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+207
+00:21:12,220 --> 00:21:17,260
+الموسيقى الإنشودة الأغنية أو عن طريق الخطوط اللي
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+208
+00:21:17,260 --> 00:21:20,580
+هو الرسم والألوان أو عن طريق الحركة الصورة
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+209
+00:21:20,580 --> 00:21:29,440
+المتحركة أو الصورة الثابتة إذا المعنى ذلكهنا هذه
+
+210
+00:21:29,440 --> 00:21:33,700
+الوسائل تتباين حسب مراحل نمو الطفل اللي هناخدها إن
+
+211
+00:21:33,700 --> 00:21:38,760
+شاء الله تعالى في محاضرات القادمة إن شاء الله إذا
+
+212
+00:21:38,760 --> 00:21:45,120
+معنى ذلك هذه الوسائل المتنوعة تحرك استجابات الطفل
+
+213
+00:21:45,120 --> 00:21:51,860
+لكي يتلقى ويستقبل الأدب بل لكي يشارك مشاركة
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+214
+00:21:51,860 --> 00:22:00,260
+إيجابية فيهم إذالابد للأدب الذي يعرض على الأطفال
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+215
+00:22:00,260 --> 00:22:08,140
+أن يحقق غاياته هذا من خصائصه من خصائص أدب الطفل
+
+216
+00:22:08,140 --> 00:22:13,520
+لابد أن يشبع اهتمامات الأطفال لابد أن يرضي
+
+217
+00:22:13,520 --> 00:22:18,380
+احتياجات الأطفال لابد هنا أن يواكي بالأدب نمو
+
+218
+00:22:18,380 --> 00:22:23,100
+الطفل ويستجيب لما يتطلبه إذا من خصائص أدب الأطفال
+
+219
+00:22:24,820 --> 00:22:30,060
+من خصائص أدب الأطفال هو أن يستجيب لرغباتهم يرضي
+
+220
+00:22:30,060 --> 00:22:34,400
+حاجاتهم لابد أن يعكس مشكلته ويتعرف عليه لابد أن
+
+221
+00:22:34,400 --> 00:22:42,660
+يقدم الحلول لهم كذلك لابد أن تكم فيه جوانب ترفيهية
+
+222
+00:22:42,660 --> 00:22:50,320
+بأن يستمتع الطفل بما في الكون من جمال إذا
+
+223
+00:22:50,320 --> 00:22:56,570
+معنى ذلكالمعرفة إذا الأطفال .. معرفة الأطفال الأدب
+
+224
+00:22:56,570 --> 00:23:03,950
+تتدرج واستعدادات الطفل لتقبل الأدب تتغير حسب طبيعة
+
+225
+00:23:03,950 --> 00:23:08,590
+فكره وخياله وبالتالي لا نستطيع أن نقول أن الطفل
+
+226
+00:23:08,590 --> 00:23:15,970
+يبقى ثابتا .. يبقى ثابتا في استقباله الأدب، لأ
+
+227
+00:23:15,970 --> 00:23:19,370
+نقول يتغير وبالتالي ما يعجب .. ما يعجب به الأطفال
+
+228
+00:23:19,370 --> 00:23:24,650
+في مرحلة طفولة مبكرةلا يعجبون بيه في مرحلة طفولة
+
+229
+00:23:24,650 --> 00:23:29,690
+متوسطة وما يعجبهم في مرحلة طفولة متوسطة لا يعجبهم
+
+230
+00:23:29,690 --> 00:23:34,010
+في مرحلة طفولة متأخرة ما السبب في ذلك النمو العقلي
+
+231
+00:23:34,010 --> 00:23:38,450
+و الفقري و الخيالي و الإدراكي و الحسيجة للأطفال بل
+
+232
+00:23:38,450 --> 00:23:43,770
+لاحظ احنا في بعض الأحيان أطفالنا يستمعون و يشاهدون
+
+233
+00:23:43,770 --> 00:23:47,170
+فضائية أطيور جنة
+
+234
+00:23:50,960 --> 00:23:57,400
+يصرون على الاستماع والمشاهدة ولكن عندما ينمو الطفل
+
+235
+00:23:57,400 --> 00:24:00,480
+في مارحة طفولة متوسطة نجد أن هذا الاهتمام يقل
+
+236
+00:24:00,480 --> 00:24:05,580
+ويتجه هذا الاهتمام نحو شئ أدب أو نوع من أنواع
+
+237
+00:24:05,580 --> 00:24:10,700
+الأدب الأخرى وبالتالي كلما ازداد النمو لدى الأطفال
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+238
+00:24:11,280 --> 00:24:14,660
+سواء كان نمو فكري أو خيالي أو معرفي أو إدراكي أو
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+239
+00:24:14,660 --> 00:24:18,660
+حسي لابد أن يعكس ذلك على اختيارهم للوسائل
+
+240
+00:24:18,660 --> 00:24:25,520
+التعبيرية التي يستخدمها الأدب في ذلك وأدب الطفل
+
+241
+00:24:25,520 --> 00:24:32,000
+لايعرف الثبات وبالتالي لابد أن يمتد إلى ما وراء
+
+242
+00:24:32,000 --> 00:24:40,540
+حدود الواقع وهذا يحدث للطفولة المتأخرة خاصةأدب
+
+243
+00:24:40,540 --> 00:24:45,620
+الطفل من خصائصه لابد أن يعكس ويواكب تطورات الحياة
+
+244
+00:24:45,620 --> 00:24:51,640
+من خصائص أدب الطفل أيضًا لابد أن يحقق الاستجابة
+
+245
+00:24:51,640 --> 00:24:56,020
+والإثارة للأطفال لابد أن يجلب انتباه الطفل لابد أن
+
+246
+00:24:56,020 --> 00:25:03,020
+يشعر الطفل اتجاهه بالقبول والمحبة في هذا الجانب
+
+247
+00:25:03,020 --> 00:25:10,280
+لذلك نجد هنا أن من خلال هذه المحاضرةتحدثنا عن
+
+248
+00:25:10,280 --> 00:25:15,940
+أهمية أدب أدب الطفل يعني معنى ذلك لابد لمن يكتب
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+249
+00:25:15,940 --> 00:25:21,500
+للأطفال أو يدرس مساق أدب الأطفال هنا أن يعرف أهمية
+
+250
+00:25:21,500 --> 00:25:29,500
+الأدب بالنسبة للطفل لأن أدب الأطفال يتمتع بخصائص
+
+251
+00:25:29,500 --> 00:25:36,450
+لابد أن تنسجم مع طبيعةالنمو الفكري و العقلي و
+
+252
+00:25:36,450 --> 00:25:39,190
+الإدراكي و الحسوس عند الطفل لابد أن نسجب مع
+
+253
+00:25:39,190 --> 00:25:44,070
+مستويات الطفولة اللي هناخدها فيما بعد الطفولة
+
+254
+00:25:44,070 --> 00:25:51,710
+المبكرة و الطفولة المتوسطة و الطفولة المتأخرة لذلك
+
+255
+00:25:51,710 --> 00:26:01,970
+نجد هنا أن أدب الطفل لابد أن يتضح مفهومه و خصائصه
+
+256
+00:26:01,970 --> 00:26:11,280
+و أهميتهوبالتالي هنا المحاضرة القادمة سنبدأ الحديث
+
+257
+00:26:11,280 --> 00:26:18,940
+عن مراحل الطفولة بمعنى أنه أدب ومراحل الطفولة
+
+258
+00:26:18,940 --> 00:26:22,640
+سنبدأ ان شاء الله تعالى في مراحل الطفولة الأولى
+
+259
+00:26:22,640 --> 00:26:28,740
+اللى يسموها مرحل الطفولة من 1 ل 3 سنوات المهن وبعد
+
+260
+00:26:28,740 --> 00:26:33,500
+ذلك ان شاء الله تعالى مرحل الطفولةالثانية المبكرة
+
+261
+00:26:33,500 --> 00:26:37,220
+الثانية في مبكرة أولى ومبكرة ثانية ناخد أنه ثانية
+
+262
+00:26:37,220 --> 00:26:41,220
+كذلك و نركز عليها وبالتالي محاضرتنا ان شاء الله
+
+263
+00:26:41,220 --> 00:26:46,700
+تعالى ستتم التركيز على أول مرحلة مراحل الطفولة و
+
+264
+00:26:46,700 --> 00:26:51,140
+هي مرحلة الطفولة الأولى من مرحل سنة إلى تالت سنوات
+
+265
+00:26:51,140 --> 00:26:55,180
+ثم ننتقل بعد ذلك إلى مرحلة الطفولة المبكرة للطفولة
+
+266
+00:26:55,180 --> 00:27:00,540
+الثانية من تالت إلى ست سنواتمرة ثانية بأكد أن
+
+267
+00:27:00,540 --> 00:27:04,720
+الكتاب المقرر علينا هو نص الأدبي لأطفال اللي هنا
+
+268
+00:27:04,720 --> 00:27:10,620
+أهدافه مصادره سيماته روي الإسلامي وهو الدكتور سعد
+
+269
+00:27:10,620 --> 00:27:15,640
+أبو أرضاوإن شاء الله تعالى في محاضرة قادمة سنحدد
+
+270
+00:27:15,640 --> 00:27:19,440
+كيفية توزيع الدرجات ونبدأ إن شاء الله تعالى في
+
+271
+00:27:19,440 --> 00:27:24,280
+تحديد التكاليف المطلوبة بالنسبة لكل طالب أو طالبة
+
+272
+00:27:24,280 --> 00:27:28,860
+في هذا المجال أرجو في محاضرة قادمة الاستعداد
+
+273
+00:27:28,860 --> 00:27:34,230
+والتحضير لما يتعلق بمراحل الطفولة سنبدأ في المرحلة
+
+274
+00:27:34,230 --> 00:27:38,770
+الأولى الطفولة الأولى اللى هو ما يتعلق بالطفولة
+
+275
+00:27:38,770 --> 00:27:43,950
+الأولى و ثم بعد ذلك الطفولة الثانية و نبدأ بعد ذلك
+
+276
+00:27:43,950 --> 00:27:50,030
+في المراحل الأخرى و كما قلت سابقا انه سيكون هناك
+
+277
+00:27:50,030 --> 00:27:56,750
+جانب تطبيقي واسع المساق يعتمد على جانب نظري قنظيري
+
+278
+00:27:56,750 --> 00:27:59,310
+و هو حيث سيكون في البداية ان ش الله تعالى و بعد
+
+279
+00:27:59,310 --> 00:28:06,750
+ذلك سيكون لدينا نصوصمسرحية و قصصية و شعرية يتم من
+
+280
+00:28:06,750 --> 00:28:11,230
+خلالها و أنا شيل يتم من خلالها فهم الجانب التطبيقى
+
+281
+00:28:11,230 --> 00:28:15,830
+و مزج الجانب النظري بالجانب التطبيقى هذا و بالله
+
+282
+00:28:15,830 --> 00:28:20,890
+التوفيق والسلام عليكم ورحمة الله وبركاته
+
diff --git a/PL9fwy3NUQKwYT4Ayhm-3qTiT1ILbX-hwD/rR7QicwJyV8_raw.json b/PL9fwy3NUQKwYT4Ayhm-3qTiT1ILbX-hwD/rR7QicwJyV8_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..4ffcf4b2b0d691488009285f5f12079ce8bcf3ae
--- /dev/null
+++ b/PL9fwy3NUQKwYT4Ayhm-3qTiT1ILbX-hwD/rR7QicwJyV8_raw.json
@@ -0,0 +1 @@
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وإيقاع الكلمات وكذلك يشعر الطفل بالقوة التأثيرية لهذه الإيقاعات لذلك هنا نجد أن الطفل يستطيع من خلال الأدب أن يحقق رغبات متعددة", "tokens": [10721, 3215, 3555, 41950, 5172, 1211, 7251, 11622, 25708, 6024, 104, 32887, 3660, 13672, 17082, 2407, 10632, 43242, 16247, 9566, 5172, 6027, 5551, 3215, 3555, 41950, 5172, 1211, 7251, 1863, 2304, 1829, 33688, 5016, 3794, 32277, 24976, 10721, 9566, 5172, 6027, 4724, 7435, 2304, 6027, 33251, 19528, 9307, 4032, 28814, 1829, 4587, 45761, 33251, 19528, 9307, 4032, 4117, 8848, 23275, 7251, 8592, 3615, 2288, 41950, 5172, 1211, 20666, 4587, 2407, 3660, 16712, 10721, 12984, 13546, 10632, 46740, 24192, 33688, 1829, 4587, 45761, 9307, 5296, 8848, 23275, 34105, 8717, 7435, 3215, 14739, 41950, 5172, 1211, 7251, 14851, 9566, 40228, 9154, 16490, 1211, 6027, 16247, 3215, 3555, 14739, 7251, 5016, 4587, 4587, 12602, 17082, 3555, 9307, 44650, 22488, 41891], "avg_logprob": -0.05915651476736796, "compression_ratio": 2.0575916230366493, "no_speech_prob": 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" الحياة", "probability": 0.99169921875}, {"start": 354.77, "end": 355.59, "word": " كذلك", "probability": 0.9236653645833334}, {"start": 355.59, "end": 356.05, "word": " أكتر", "probability": 0.9713134765625}, {"start": 356.05, "end": 357.07, "word": " تكيفا", "probability": 0.87158203125}, {"start": 357.07, "end": 357.99, "word": " مع", "probability": 0.88037109375}, {"start": 357.99, "end": 359.97, "word": " احتجاجات", "probability": 0.82373046875}, {"start": 359.97, "end": 360.81, "word": " الحياة", "probability": 0.9900716145833334}, {"start": 360.81, "end": 361.55, "word": " وبالتالي", "probability": 0.94990234375}, {"start": 361.55, "end": 362.11, "word": " يستطيع", "probability": 0.975830078125}, {"start": 362.11, "end": 362.73, "word": " الأدب", "probability": 0.99072265625}, {"start": 362.73, "end": 363.37, "word": " أن", "probability": 0.8505859375}, {"start": 363.37, "end": 364.07, "word": " يربط", "probability": 0.9518229166666666}, {"start": 364.07, "end": 364.55, "word": 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الإلزامية التعليمية أو في القراءة الحرة ومن هنا بالمعنى العام أما المعنى الخاص نقول أن أدب الطفل هو الكلام الجيد الجميل كلام جيد وجميل يجد باهتمام الطفل", "tokens": [41185, 9122, 2655, 3555, 4032, 36081, 2304, 6055, 29245, 1829, 3224, 29538, 33251, 2655, 16758, 9307, 30731, 16247, 9566, 5172, 6027, 8608, 2407, 16606, 8978, 9673, 4587, 9640, 9307, 32748, 23557, 3794, 10632, 25062, 2288, 16606, 3660, 33688, 1211, 11622, 10943, 10632, 16712, 3615, 20292, 2304, 10632, 34051, 8978, 25062, 2288, 16606, 3660, 21542, 25720, 4032, 27842, 34105, 20666, 2304, 3615, 1863, 7578, 18863, 10943, 5551, 15042, 9673, 3615, 1863, 7578, 33962, 33546, 8717, 39648, 14739, 5551, 3215, 3555, 41950, 5172, 1211, 31439, 2423, 28820, 10943, 25724, 25708, 25724, 2304, 26895, 28242, 10943, 10874, 25708, 49610, 2304, 26895, 7251, 7435, 3215, 4724, 40294, 39237, 10943, 41950, 5172, 1211], "avg_logprob": -0.11374713466801775, "compression_ratio": 2.0439024390243903, "no_speech_prob": 1.0073184967041016e-05, "words": 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0.8052734375}, {"start": 1683.03, "end": 1683.59, "word": " و", "probability": 0.955078125}, {"start": 1683.59, "end": 1684.35, "word": " قصصية", "probability": 0.8524169921875}, {"start": 1684.35, "end": 1684.91, "word": " و", "probability": 0.990234375}, {"start": 1684.91, "end": 1685.57, "word": " شعرية", "probability": 0.9407958984375}, {"start": 1685.57, "end": 1686.63, "word": " يتم", "probability": 0.6129150390625}, {"start": 1686.63, "end": 1686.75, "word": " من", "probability": 0.9638671875}, {"start": 1686.75, "end": 1687.27, "word": " خلالها", "probability": 0.9947509765625}, {"start": 1687.27, "end": 1687.37, "word": " و", "probability": 0.433349609375}, {"start": 1687.37, "end": 1687.55, "word": " أنا", "probability": 0.6513671875}, {"start": 1687.55, "end": 1687.93, "word": " شيل", "probability": 0.799560546875}, {"start": 1687.93, "end": 1688.33, "word": " يتم", "probability": 0.900146484375}, {"start": 1688.33, "end": 1688.47, "word": " من", "probability": 0.986328125}, {"start": 1688.47, "end": 1689.05, "word": " خلالها", "probability": 0.992919921875}, {"start": 1689.05, "end": 1689.57, "word": " فهم", "probability": 0.982421875}, {"start": 1689.57, "end": 1690.09, "word": " الجانب", "probability": 0.951171875}, {"start": 1690.09, "end": 1691.23, "word": " التطبيقى", "probability": 0.830517578125}, {"start": 1691.23, "end": 1691.37, "word": " و", "probability": 0.974609375}, {"start": 1691.37, "end": 1691.79, "word": " مزج", "probability": 0.93896484375}, {"start": 1691.79, "end": 1692.27, "word": " الجانب", "probability": 0.9762369791666666}, {"start": 1692.27, "end": 1692.67, "word": " النظري", "probability": 0.8889973958333334}, {"start": 1692.67, "end": 1693.17, "word": " بالجانب", "probability": 0.9713134765625}, {"start": 1693.17, "end": 1694.11, "word": " التطبيقى", "probability": 0.9900390625}, {"start": 1694.11, "end": 1694.85, "word": " هذا", "probability": 0.9150390625}, {"start": 1694.85, "end": 1695.47, "word": " و", "probability": 0.7041015625}, {"start": 1695.47, "end": 1695.83, "word": " بالله", "probability": 0.96484375}, {"start": 1695.83, "end": 1696.57, "word": " التوفيق", "probability": 0.9915771484375}, {"start": 1696.57, "end": 1697.65, "word": " والسلام", "probability": 0.8250325520833334}, {"start": 1697.65, "end": 1698.27, "word": " عليكم", "probability": 0.957763671875}, {"start": 1698.27, "end": 1699.23, "word": " ورحمة", "probability": 0.943115234375}, {"start": 1699.23, "end": 1699.51, "word": " الله", "probability": 0.96875}, {"start": 1699.51, "end": 1700.89, "word": " وبركاته", "probability": 0.9837890625}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 1702.440625, "duration_after_vad": 1648.4456249999969}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwYT4Ayhm-3qTiT1ILbX-hwD/rR7QicwJyV8_raw.srt b/PL9fwy3NUQKwYT4Ayhm-3qTiT1ILbX-hwD/rR7QicwJyV8_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..49e3cf28521eba1f0fdf31f102d1aef64b6de7fb
--- /dev/null
+++ b/PL9fwy3NUQKwYT4Ayhm-3qTiT1ILbX-hwD/rR7QicwJyV8_raw.srt
@@ -0,0 +1,1128 @@
+1
+00:00:00,960 --> 00:00:05,480
+بسم الله الرحمن الرحيم هذه المحاضرة التانية محاضرة
+
+2
+00:00:05,480 --> 00:00:12,980
+أدب الأطفال الكتاب المقرر علينا في هذا المثاق هو
+
+3
+00:00:12,980 --> 00:00:18,000
+النص الأدبي للأطفال من تأليف سعد أبو الرضاأحنا
+
+4
+00:00:18,000 --> 00:00:21,880
+خدنا في المحاضرة الأولى حديث عن الأدب والثقافة
+
+5
+00:00:21,880 --> 00:00:29,000
+فتحدثنا عن مفهوم الأدب و التطور الدلالي لمفرط
+
+6
+00:00:29,000 --> 00:00:34,520
+الأدب ما بين الجانب الحسي المادي والجانب المعنوي
+
+7
+00:00:34,520 --> 00:00:39,280
+ثم بعد ذلك تحدثنا عن الثقافة و علاقة الثقافة
+
+8
+00:00:39,280 --> 00:00:44,780
+بالأدب و كيف يمكن للأدب أن يعبر على الثقافة ثم بعد
+
+9
+00:00:44,780 --> 00:00:51,230
+ذلك اتقلنا للحديثعن التجسيد التجسيد الفني للأدب
+
+10
+00:00:51,230 --> 00:00:57,550
+وأهمية هذا التجسيد الفني للأدب وانعكسات هذا
+
+11
+00:00:57,550 --> 00:01:02,050
+التجسيد على الأدب على الطفل محيط استقبال الأدب
+
+12
+00:01:02,050 --> 00:01:07,250
+وأدب الأطفال وكيف يهيئ التجسيد الفني للطفل
+
+13
+00:01:07,250 --> 00:01:12,830
+لاستقبال الأدبهذه المحاضرة اللي هي المحاضرة
+
+14
+00:01:12,830 --> 00:01:16,090
+التانية موجودة في الكتاب تحت عنوان أهمية أدب
+
+15
+00:01:16,090 --> 00:01:20,730
+الأطفال الإسلامي أهمية
+
+16
+00:01:20,730 --> 00:01:28,290
+أدب الأطفال الإسلامي تكمن هنا أهمية الأدب بالنسبة
+
+17
+00:01:28,290 --> 00:01:34,130
+للطفل قبل أن نعرف هذه الأهمية لابد أن نتعرف على
+
+18
+00:01:34,130 --> 00:01:40,810
+احتياجاتالأطفال على اهتمامات الأطفال على مشكلات
+
+19
+00:01:40,810 --> 00:01:49,390
+الأطفال لابد لمن يدرس أو يكتب للطفل أن يعرف مشكلات
+
+20
+00:01:49,390 --> 00:01:52,390
+الأطفال لابد أن يتعرف كذلك ويقدم لهم الحلول لهذه
+
+21
+00:01:52,390 --> 00:02:00,030
+المشكلات ومن هنا يستخدم الأدب في
+
+22
+00:02:00,030 --> 00:02:06,440
+زرع القيم والمبادئ والمثل للأطفالو من هنا نستطيع
+
+23
+00:02:06,440 --> 00:02:13,360
+أن نقول أن أدب الأطفال يستخدم وسيلة حضارية إنسانية
+
+24
+00:02:13,360 --> 00:02:18,820
+فكرية علمية إلى آخره من أجل إرسال هذه القيم وسيلة
+
+25
+00:02:18,820 --> 00:02:27,340
+إذا الطفل اليوم هو رجل المستقبل و لابد هنا أن
+
+26
+00:02:27,340 --> 00:02:33,530
+نبلور شخصية هذا الطفل عن طريق الأدببكل فنون
+
+27
+00:02:33,530 --> 00:02:38,490
+المتنوعة سواء كان قصة أو مسرحية أو نشيد أو غير ذلك
+
+28
+00:02:38,490 --> 00:02:45,770
+إذا هناك وسائل ينقل من خلال الأدب أو يتوظف من خلال
+
+29
+00:02:45,770 --> 00:02:50,670
+الأدب من أجل التأثير في الأطفال وجذب انتباه
+
+30
+00:02:50,670 --> 00:02:55,130
+الأطفال من أجل غرس القيم والمبادئ والأفكار
+
+31
+00:02:55,130 --> 00:03:02,430
+المتنوعة التي يريد الأب أو المعلمأن يرسخها في وجود
+
+32
+00:03:02,430 --> 00:03:07,090
+الأطفال إذا لابد للأدب أن يشبع اهتمام اهتمامات
+
+33
+00:03:07,090 --> 00:03:12,310
+الطفل لابد للأدب أن يلبح احتياجات ورغبات الطفل
+
+34
+00:03:12,310 --> 00:03:17,770
+لابد للأدب أن يقدم للطفل غذاء نفسي وفكري وغذاء
+
+35
+00:03:17,770 --> 00:03:24,670
+معنوي لابد للأدب أن يرقاه بالأطفال
+
+36
+00:03:25,700 --> 00:03:30,000
+على مستوى الفكري على مستوى الخيال على مستوى النمو
+
+37
+00:03:30,000 --> 00:03:35,640
+الحسي لذلك هنا لابد أن يقدم الأدب للطفل معلومات
+
+38
+00:03:35,640 --> 00:03:44,160
+علمية فنية جمالية دينية تاريخية قومية أي الأخرى
+
+39
+00:03:44,160 --> 00:03:48,760
+كذلك لابد للأدب أن يتوافق مع استعدادات الطفل
+
+40
+00:03:48,760 --> 00:03:56,490
+وميوله نحو اللعب وبالتالي الأدبيكون وسيلة ترفيهية
+
+41
+00:03:56,490 --> 00:04:04,550
+ووسيلة تعليمية للأطفال لابد أن يكتشف الطفل من خلال
+
+42
+00:04:04,550 --> 00:04:11,190
+أدب أشياء جديدة ويترك للطفل حرية الاختيار للأنواع
+
+43
+00:04:11,190 --> 00:04:17,690
+الأدبية التي ينسجم معها وتحقق احتياجاته وتلبي
+
+44
+00:04:17,690 --> 00:04:29,040
+رغباته كذلك لابد أن يتحولالطفل في معرفته للأدب من
+
+45
+00:04:29,040 --> 00:04:37,800
+الجانب الترفيهي إلى الجانب التعليمي ومن هنا تحدث
+
+46
+00:04:37,800 --> 00:04:45,760
+مشاركة وجدانية عقلية خيالية نفسية بين فنون الأدب
+
+47
+00:04:45,760 --> 00:04:53,300
+وبين الطفل وبالتالي تتحقق إشباع اهتمامات
+
+48
+00:04:55,280 --> 00:05:00,680
+ورغبات الطفل لذلك
+
+49
+00:05:00,680 --> 00:05:07,220
+نقول أن الطفل بحاجة إلى أدب خاصة في السنوات الأولى
+
+50
+00:05:07,220 --> 00:05:13,020
+السنوات التكوينية التي تبلور شخصية الطفل لذلك تكمن
+
+51
+00:05:13,020 --> 00:05:21,520
+أهمية أدب الأطفال في نقل المعرفة إلى الطفل ونقل
+
+52
+00:05:21,520 --> 00:05:27,420
+التجارب البشريةأدب الطفل يزيد الثروة اللغوية عند
+
+53
+00:05:27,420 --> 00:05:32,280
+الأطفال أدب الطفل ينمي الإحساس للأطفال بجمال
+
+54
+00:05:32,280 --> 00:05:38,740
+الكلمات وإيقاع الكلمات وكذلك يشعر الطفل بالقوة
+
+55
+00:05:38,740 --> 00:05:43,420
+التأثيرية لهذه الإيقاعات لذلك هنا نجد أن الطفل
+
+56
+00:05:43,420 --> 00:05:48,310
+يستطيع من خلال الأدب أن يحقق رغبات متعددةفيكون من
+
+57
+00:05:48,310 --> 00:05:52,470
+خلال الأدب أكتر قابولة للحياة و أكتر تفهما
+
+58
+00:05:52,470 --> 00:06:00,810
+لمتغيرات الحياة كذلك أكتر تكيفا مع احتجاجات الحياة
+
+59
+00:06:00,810 --> 00:06:06,570
+وبالتالي يستطيع الأدب أن يربط ما بين الواقع المعاش
+
+60
+00:06:06,570 --> 00:06:12,900
+والماضي ويؤدي الدور المستقبليومن هنا نقول أن الأدب
+
+61
+00:06:12,900 --> 00:06:20,580
+له دور مهم في غرز القيم الدينية والمبادئ الأخلاقية
+
+62
+00:06:20,580 --> 00:06:28,200
+الإسلامية التي تعزز بناء شخصية الطفل لذلك نجد هناك
+
+63
+00:06:28,200 --> 00:06:34,680
+علاقة وثيقة ما بين الكلمة والمعتقد والعقيدة
+
+64
+00:06:34,680 --> 00:06:38,760
+الإسلامية وبالتالي
+
+65
+00:06:38,760 --> 00:06:45,660
+يتجاوز الأدبكونه وسيلة ترفيهية إلى وسيلة تعليمية
+
+66
+00:06:45,660 --> 00:06:49,900
+البداية الأدب تكون وسيلة ترفيهية ثم مع النمو و
+
+67
+00:06:49,900 --> 00:06:54,540
+التطور الذي يحدث للطفل يتحول من الوسيلة الترفيهية
+
+68
+00:06:54,540 --> 00:07:04,460
+إلى وسيلة تعليمية فنلاحظ أن الأدب يجسد جانب وجداني
+
+69
+00:07:04,460 --> 00:07:10,940
+يعزز جانب التعاون مع باقي الأطفال يدعم
+
+70
+00:07:12,960 --> 00:07:21,360
+التواصل بين الأطفال يشكل وجدان الأطفال يسقل مشاعر
+
+71
+00:07:21,360 --> 00:07:26,780
+الأطفال يعزز تنشأ السوية السليمة لديهم يعزز قيم
+
+72
+00:07:26,780 --> 00:07:33,260
+الحق والخير والجمال للأطفال لذلك هنا نجد أن أدب
+
+73
+00:07:33,260 --> 00:07:38,560
+الأطفال أدب الأطفال يجب أن ينهض بما يدعو إليه
+
+74
+00:07:38,560 --> 00:07:42,830
+الإسلامبمعنى أن أدب الطفل لابد أن يحمل في داخله
+
+75
+00:07:42,830 --> 00:07:49,950
+رسالة وهذه الرسالة تعزز القيم الإسلامية والمبادئ
+
+76
+00:07:49,950 --> 00:07:55,570
+الدينية لديه بحب العلم والسعادة في رضا الله والقيم
+
+77
+00:07:55,570 --> 00:07:59,590
+الدينية متعلقة بالصدق والإخلاص والأمانة والمحبة
+
+78
+00:07:59,590 --> 00:08:04,610
+وغير ذلك إضافة إلى ذلك أن أدب الطفل ينمي الخيال
+
+79
+00:08:04,610 --> 00:08:08,790
+للأطفال ويطلق لديهم التفكير
+
+80
+00:08:11,310 --> 00:08:17,110
+في أشياء متعددة ومتنوعة وبالتالي نستطيع أن نقول أن
+
+81
+00:08:17,110 --> 00:08:22,770
+أدب الطفل يسهم إسهاما كبيرا في تحقيق الاستقرار
+
+82
+00:08:22,770 --> 00:08:30,210
+والتوازن النفسي لدى الأطفال إضافة إلى ذلك نقول أن
+
+83
+00:08:30,210 --> 00:08:38,810
+أهمية أدب الطفل تقمن في أنه يساعد على بناء الشخصية
+
+84
+00:08:38,810 --> 00:08:45,510
+للطفليساعد على بناء الطفل من ناحية نفسية ومن ناحية
+
+85
+00:08:45,510 --> 00:08:52,210
+عقلية وخيالية مراعية الخصائص لأن كل مراحل من مراحل
+
+86
+00:08:52,210 --> 00:08:59,350
+الطفولة لها ما يناسبها من الأدب فلذلك الأدب يقدم
+
+87
+00:08:59,350 --> 00:09:05,530
+للأطفال معيارا أخلاقيا، دينيا، اجتماعيا، معيارا
+
+88
+00:09:05,530 --> 00:09:13,210
+ترفيهيالذلك لا يمكن أن ينفصل المعيار الأخلاقي أو
+
+89
+00:09:13,210 --> 00:09:18,310
+الديني أو الموضوعي عن المعيار الفني لذلك نستطيع أن
+
+90
+00:09:18,310 --> 00:09:22,890
+نقول أن أدب الطفل في داخله بنية متراكبة لا يمكن أن
+
+91
+00:09:22,890 --> 00:09:31,850
+ينفصل فيها الشكل عن المضمون فكلاهما يعزز وجود
+
+92
+00:09:31,850 --> 00:09:37,310
+الآخر لأن الأدب تعبير عن الحضارة الإنسانيةومن هنا
+
+93
+00:09:37,310 --> 00:09:45,610
+نقول الطفل بحاجة إلى أن يتعرف على ذاته يتعرف على
+
+94
+00:09:45,610 --> 00:09:50,310
+البيئة المحيطة به كيف يمكن أن يتعرف على ذاته أو
+
+95
+00:09:50,310 --> 00:09:54,770
+يتعرف على البيئة المحيطة به الأدب أدب الأطفال بكل
+
+96
+00:09:54,770 --> 00:09:59,950
+أنواعه الأدبية سواء كان شعر أو نفع يسهم إسهاما
+
+97
+00:09:59,950 --> 00:10:06,070
+كبيرا في تهيئة الفرصة اللازمةأمام الطفل للتعرف على
+
+98
+00:10:06,070 --> 00:10:12,010
+ذاته وعلى البيئة المحيطة به حيث
+
+99
+00:10:12,010 --> 00:10:19,770
+يقدم مجموع من الخبرات للأطفال لذلك أدب الطفل يسهم
+
+100
+00:10:19,770 --> 00:10:25,570
+في صياغة عقل الطفل وتنمية الخيال إليه أدب الطفل من
+
+101
+00:10:25,570 --> 00:10:33,610
+أهميته ومكانته البناءة ينمي الإحساس للأطفال يزيد
+
+102
+00:10:34,250 --> 00:10:41,310
+وعي الطفل لفهم الواقع المعاش ووعيه بالماضي
+
+103
+00:10:41,310 --> 00:10:46,990
+واستشرافي لأفاق المستقبل لذلك أدب الطفل يعد وسيطا
+
+104
+00:10:46,990 --> 00:10:53,450
+تربويا يتيح الفرصة أمام الأطفال لمعرفة كثير من
+
+105
+00:10:53,450 --> 00:10:56,750
+الأسئلة لمعرفة كثير من الإجابات عن الأسئلة
+
+106
+00:10:56,750 --> 00:11:03,000
+والاستفسارات التي تدور في ألهانهمأدب الطفل يعتبر
+
+107
+00:11:03,000 --> 00:11:07,880
+وسيطا تربويا يتيح الفرصة أمام الأطفال لمعرفة
+
+108
+00:11:07,880 --> 00:11:13,480
+الإجابات عن كثير من الأسئلة والاستفسارات ومحاولات
+
+109
+00:11:13,480 --> 00:11:18,980
+الكشف والتعرف على الأشياء من حولهم لذلك أدب الطفل
+
+110
+00:11:18,980 --> 00:11:25,600
+أيضا ينقل للأطفال الخبرات سواء الماضي أو في الواقع
+
+111
+00:11:25,600 --> 00:11:33,230
+المعاشر أدب الأطفاليتيح الفرصة أمام الطفل لتحقيق
+
+112
+00:11:33,230 --> 00:11:41,670
+الثقة بالنفس من خلال ثقل شخصي الطفل التي يعمل أدب
+
+113
+00:11:41,670 --> 00:11:46,590
+على أن يشارك الطفل في الأعمال الجماعية كالمسرحيات
+
+114
+00:11:46,590 --> 00:11:53,070
+والتمثيل والأناشيد تكون أعمال جماعية وليست فردية
+
+115
+00:11:53,070 --> 00:11:59,170
+فيعزز دي فرصة الاحتكاكبالاخرين وهنا تقمن أو يعزز
+
+116
+00:11:59,170 --> 00:12:09,750
+الثقة بالنفس كذلك نجد أن أدب الطفل يمكن الأطفال من
+
+117
+00:12:09,750 --> 00:12:20,110
+التحرر من العادات والتقاليد السيئة ويرسخ لديهم
+
+118
+00:12:20,110 --> 00:12:29,250
+الخبرة والقيم البناءةالخبرات والقيم البناء يوفر
+
+119
+00:12:29,250 --> 00:12:36,910
+للأطفال أسباب الترويح والترفيه عن أنفسهم ويوفر لهم
+
+120
+00:12:36,910 --> 00:12:44,930
+القيم العلمية والدينية والتربوية وما يتعلق بالبيئة
+
+121
+00:12:44,930 --> 00:12:50,430
+المحيطة بهم لذلك نجد في أدب الطفل جوانب تاريخية
+
+122
+00:12:50,430 --> 00:12:58,120
+تزويد الطفل بما يتعلق بثقافة الماضي نجد في أدب
+
+123
+00:12:58,120 --> 00:13:05,380
+الطفل نواحي دينية و هي قصص الدينية نلاحظ أنها
+
+124
+00:13:05,380 --> 00:13:11,080
+كنواحي قومية الأحداث والشخصيات التي تسهم في بناء
+
+125
+00:13:11,080 --> 00:13:16,500
+التاريخكذلك نجد هناك نواحي ثقافية تزوّل الأطفال
+
+126
+00:13:16,500 --> 00:13:19,440
+بالمعلومات المختلفة عن الثقاف و عن الحضارات و عن
+
+127
+00:13:19,440 --> 00:13:26,200
+التقاليد و عن الأمم المختلفة و الشعوب الأخرى في
+
+128
+00:13:26,200 --> 00:13:30,660
+نواحي عقلية يزوّل الأدب الطفل بالنواحي عقليةينمي
+
+129
+00:13:30,660 --> 00:13:38,080
+لديهم فهم العلم والتطور التكنولوجي والحضارة يعزز
+
+130
+00:13:38,080 --> 00:13:43,180
+لديهم فهم طبيعة المقترعات الحديثة الإلكترونية كذلك
+
+131
+00:13:43,180 --> 00:13:50,580
+يعزز لديهم نواحي أخلاقية التعلق بمحاكاة الأنبياء
+
+132
+00:13:50,580 --> 00:13:55,000
+والرسل والصحابة والتابعين والشخصيات المتنوعة يعزز
+
+133
+00:13:55,000 --> 00:13:59,400
+لديهم كذلك أدب الأطفال جوانب النواحي الترويحية
+
+134
+00:13:59,400 --> 00:14:06,650
+والنفسيةالطفل يجد هناك جوانب ترفيه هي يتسلق من
+
+135
+00:14:06,650 --> 00:14:14,570
+خلال .. يتسلق و يروح عن .. و يرفع عن نفسه من خلال
+
+136
+00:14:14,570 --> 00:14:20,590
+الاسماع أو القراءة في أدب الأطفال هذه ما هو ما
+
+137
+00:14:20,590 --> 00:14:27,730
+يتعلق بأدب أو أهمية أدب الطفل
+
+138
+00:14:30,900 --> 00:14:36,300
+نأتي إلى الجزء الآخر من هذه المحاضرة فيما يتعلق
+
+139
+00:14:36,300 --> 00:14:43,160
+بأذب الأطفال نبدأ بالمفهوم إذا كان أذب الأطفال
+
+140
+00:14:43,160 --> 00:14:48,040
+بمعناه العام بمعنى العام ماذا يقصد به؟ إنتاج عقلي
+
+141
+00:14:48,040 --> 00:14:51,200
+مدون
+
+142
+00:14:51,200 --> 00:14:57,700
+في الكتب وموجه لمن؟ للأطفال هذا بمعناه العام يعني
+
+143
+00:14:57,700 --> 00:15:03,050
+إنتاج عقلي يكتبه الكبارفي كتب ويتم توجيه هذه
+
+144
+00:15:03,050 --> 00:15:06,770
+الكتابات إلى الأطفال سواء في المقارات الدراسية
+
+145
+00:15:06,770 --> 00:15:11,690
+القراءة الإلزامية التعليمية أو في القراءة الحرة
+
+146
+00:15:11,690 --> 00:15:21,370
+ومن هنا بالمعنى العام أما المعنى الخاص نقول أن أدب
+
+147
+00:15:21,370 --> 00:15:27,430
+الطفل هو الكلام الجيد الجميل كلام جيد وجميل يجد
+
+148
+00:15:27,430 --> 00:15:33,080
+باهتمام الطفلوماذا ويحدث في نفسهم أيضًا متعة فنية
+
+149
+00:15:33,080 --> 00:15:43,420
+ويثري فكر الأطفال وهذا الأدب سواء كان أدبًا شفويا
+
+150
+00:15:43,420 --> 00:15:51,160
+مشفوعا بالكلام أو أدبًا تحريريا بالكتابة وهذا
+
+151
+00:15:51,160 --> 00:15:56,910
+الأدب ما يتعلق بالجانب الشفوي أو التحريرييختلف حسب
+
+152
+00:15:56,910 --> 00:16:00,850
+اللي هو مراحل نمو الطفل لأن في مرحل من مراحل لا
+
+153
+00:16:00,850 --> 00:16:05,130
+يستطيع الطفل أن يعتمد على نفسه في القراءة فيلجأ
+
+154
+00:16:05,130 --> 00:16:09,370
+إلى الاستماع أما في مراحل الطفولة المتوسطة خاصة في
+
+155
+00:16:09,370 --> 00:16:14,330
+نهاياتها والطفولة المتأخرة يستطيع الطفل أن يعتمد
+
+156
+00:16:14,330 --> 00:16:19,890
+على نفسه في القراءة وبالتالي قد يستعين بكبار السن
+
+157
+00:16:19,890 --> 00:16:29,220
+والآخرينعن ذلك نجد هنا عندما نقول أدب الطفل هنا
+
+158
+00:16:29,220 --> 00:16:33,900
+نأتي إلى المفهوم كلام جيد لابد أن يحدث في نفس
+
+159
+00:16:33,900 --> 00:16:41,780
+الأطفال متعة فنية وهذه متعة فنية تشكل عنصرا أو
+
+160
+00:16:41,780 --> 00:16:46,620
+عنصر من عناصر الجدب بالنسبة
+
+161
+00:16:46,620 --> 00:16:52,760
+للطفل إذا كلام جيد وهذا كلام جيديمكن أن يكون شعرا
+
+162
+00:16:52,760 --> 00:16:58,500
+أو نفرا يتسم بالجمال هذا الكلام الجيد والجميل يحمل
+
+163
+00:16:58,500 --> 00:17:06,960
+في داخله قيم ترفيهية وقيم علمية قيم ترفيهية وقيم
+
+164
+00:17:06,960 --> 00:17:18,660
+علمية إضافة إلى ذلك نجد أن أدب الطفل لابد أن يتسم
+
+165
+00:17:20,060 --> 00:17:24,980
+بخصائص إذا المفهوم واضح مفهوم أدب الطفل بالنسبة
+
+166
+00:17:24,980 --> 00:17:31,200
+للكبار والصغار ليس واحدا وإنما هناك نقاط التقاء
+
+167
+00:17:31,200 --> 00:17:35,580
+بينهما لا نستطيع أن نقول أن مفهوم أدب الطفل يختلف
+
+168
+00:17:35,580 --> 00:17:40,100
+اختلافا كليا عن أدب الكبار أو الأطفال لأ هناك
+
+169
+00:17:40,100 --> 00:17:44,320
+التقاء في المفهوم ولكن هذا التقاء في جوانب واختلاف
+
+170
+00:17:44,320 --> 00:17:51,010
+في جوانب أخرىلذلك لابد إذا أذب الطفل معناه العام
+
+171
+00:17:51,010 --> 00:17:56,530
+مفهومه الإنتاج العقلي المدون في كتب موجهة لمين
+
+172
+00:17:56,530 --> 00:18:01,650
+للأطفال ما الذي يدون؟ الكبار وهذا التدون يكون إما
+
+173
+00:18:01,650 --> 00:18:05,670
+في مقرات دراسية اللي بياخدها الطالب في المدرسة أو
+
+174
+00:18:05,670 --> 00:18:09,630
+في الروضة في مراحل مختلفة أو قراءة حرة لما هو
+
+175
+00:18:09,630 --> 00:18:15,130
+يختار روح المكتبة ويختار كتب خاصة بالأطفال هذا
+
+176
+00:18:15,130 --> 00:18:20,020
+المعنى العام أما المعنى الخاصالكلام الجميل كلام
+
+177
+00:18:20,020 --> 00:18:25,620
+الجيد الجميل لاحظوا كلمة جيد و الجميل onesogenic و
+
+178
+00:18:25,620 --> 00:18:31,620
+الكلام مسموع و قد يكون مقرؤ و قد يكون مرئي من خلال
+
+179
+00:18:31,620 --> 00:18:36,420
+التمثيل وهنا يبين أن أساس أذب الطفل يعتمد على
+
+180
+00:18:36,420 --> 00:18:41,920
+الكلمة المموثقة خاصة في مراحة الطفولة المبكرة أو
+
+181
+00:18:41,920 --> 00:18:48,550
+نهايات مراحة المهديحدث في نفوس الأطفال متعة ثنية
+
+182
+00:18:48,550 --> 00:18:53,150
+في متعة ينجذب الطفل ويشعر بالراحة النفسية إلى جانب
+
+183
+00:18:53,150 --> 00:18:59,610
+المتعة الفنية هناك إثراء للفكر أدب الطفل لابد أن
+
+184
+00:18:59,610 --> 00:19:05,290
+يكون مشهورا بالكلام هنا مشهورا بالكلام إما أن يكون
+
+185
+00:19:05,290 --> 00:19:09,710
+عبارة عن أناشيد أو أغاني أو مسرحيات أو قصص مختلفة
+
+186
+00:19:11,870 --> 00:19:20,570
+أدب الطفل من خصائصه لابد أن يكون مناسبا للصغار لأن
+
+187
+00:19:20,570 --> 00:19:24,610
+أدب الكبار يختلف عن أدب الصغار إذا كنا مناسبا طب
+
+188
+00:19:24,610 --> 00:19:30,610
+ما نوع هذا التناسب هو التناسب الأخلاقي لابد أنه
+
+189
+00:19:30,610 --> 00:19:38,890
+حافظ على أخلاق الطفل الأطفال لابد أن لا يفسد الأدب
+
+190
+00:19:38,890 --> 00:19:43,550
+الجانب الأخلاقيوالقيمة عند الأطفال هذا الأول إذا
+
+191
+00:19:43,550 --> 00:19:47,090
+التناسب و أخلاق التناسب الثاني تناسب تعليمي في
+
+192
+00:19:47,090 --> 00:19:51,650
+مقام التعليم أي ينبغي على أدب الطفل اللي يتجاوز
+
+193
+00:19:51,650 --> 00:19:57,370
+مستوى العقلي و الإدراك عند الأطفال إذا أدب الطفل
+
+194
+00:19:57,370 --> 00:20:02,230
+الإسلامي من خصائصه أنه يتخذ أو أدب الطفل بشكل عام
+
+195
+00:20:02,230 --> 00:20:08,930
+يتخذ الكلمة وسيلة تعبيرالجميل وهذا إذا اتخذ الكلمة
+
+196
+00:20:08,930 --> 00:20:13,650
+الجميلة وسيلة التعبير يتحقق في ذلك أو من خلال هذه
+
+197
+00:20:13,650 --> 00:20:17,450
+الاستخدام أشياء متعددة يرسخ العقيدة يديهم يثر
+
+198
+00:20:17,450 --> 00:20:25,650
+الفكر يشعرون اتجاهه بالمتعة الوجدانية إذا المعنى
+
+199
+00:20:25,650 --> 00:20:32,070
+ذلك أدب الطفل يتجاوز أدب الأطفال يتجاوز المفهوم
+
+200
+00:20:32,840 --> 00:20:36,320
+التقليد بأن الكلمة هي المادة الأساسية إلى وسائل
+
+201
+00:20:36,320 --> 00:20:43,660
+متعدلة يعني يتخذ أدب الطفل وسائل التي يتخذها من
+
+202
+00:20:43,660 --> 00:20:49,060
+أجل أو يعتمدها في إصال المعرفة للطفل نقول قد يأخذ
+
+203
+00:20:49,060 --> 00:20:54,040
+الكلمة أو النغمة أو يكون الرسم أو الصورة المتحركة
+
+204
+00:20:54,040 --> 00:21:00,780
+أو الصامتةإذا المعنى ذلك أن وسائل الأدب الوسائل
+
+205
+00:21:00,780 --> 00:21:06,360
+التي تقدم الأدب للأطفال متنوعة قد يقدم الأدب للطفل
+
+206
+00:21:06,360 --> 00:21:12,220
+عن طريق كلمة يسمعها أو يقرأها أو النغمة عن طريق
+
+207
+00:21:12,220 --> 00:21:17,260
+الموسيقى الإنشودة الأغنية أو عن طريق الخطوط اللي
+
+208
+00:21:17,260 --> 00:21:20,580
+هو الرسم والألوان أو عن طريق الحركة الصورة
+
+209
+00:21:20,580 --> 00:21:29,440
+المتحركة أو الصورة الثابتة إذا المعنى ذلكهنا هذه
+
+210
+00:21:29,440 --> 00:21:33,700
+الوسائل تتباين حسب مراحل نمو الطفل اللي هناخدها إن
+
+211
+00:21:33,700 --> 00:21:38,760
+شاء الله تعالى في محاضرات القادمة إن شاء الله إذا
+
+212
+00:21:38,760 --> 00:21:45,120
+معنى ذلك هذه الوسائل المتنوعة تحرك استجابات الطفل
+
+213
+00:21:45,120 --> 00:21:51,860
+لكي يتلقى ويستقبل الأدب بل لكي يشارك مشاركة
+
+214
+00:21:51,860 --> 00:22:00,260
+إيجابية فيهم إذالابد للأدب الذي يعرض على الأطفال
+
+215
+00:22:00,260 --> 00:22:08,140
+أن يحقق غاياته هذا من خصائصه من خصائص أدب الطفل
+
+216
+00:22:08,140 --> 00:22:13,520
+لابد أن يشبع اهتمامات الأطفال لابد أن يرضي
+
+217
+00:22:13,520 --> 00:22:18,380
+احتياجات الأطفال لابد هنا أن يواكي بالأدب نمو
+
+218
+00:22:18,380 --> 00:22:23,100
+الطفل ويستجيب لما يتطلبه إذا من خصائص أدب الأطفال
+
+219
+00:22:24,820 --> 00:22:30,060
+من خصائص أدب الأطفال هو أن يستجيب لرغباتهم يرضي
+
+220
+00:22:30,060 --> 00:22:34,400
+حاجاتهم لابد أن يعكس مشكلته ويتعرف عليه لابد أن
+
+221
+00:22:34,400 --> 00:22:42,660
+يقدم الحلول لهم كذلك لابد أن تكم فيه جوانب ترفيهية
+
+222
+00:22:42,660 --> 00:22:50,320
+بأن يستمتع الطفل بما في الكون من جمال إذا
+
+223
+00:22:50,320 --> 00:22:56,570
+معنى ذلكالمعرفة إذا الأطفال .. معرفة الأطفال الأدب
+
+224
+00:22:56,570 --> 00:23:03,950
+تتدرج واستعدادات الطفل لتقبل الأدب تتغير حسب طبيعة
+
+225
+00:23:03,950 --> 00:23:08,590
+فكره وخياله وبالتالي لا نستطيع أن نقول أن الطفل
+
+226
+00:23:08,590 --> 00:23:15,970
+يبقى ثابتا .. يبقى ثابتا في استقباله الأدب، لأ
+
+227
+00:23:15,970 --> 00:23:19,370
+نقول يتغير وبالتالي ما يعجب .. ما يعجب به الأطفال
+
+228
+00:23:19,370 --> 00:23:24,650
+في مرحلة طفولة مبكرةلا يعجبون بيه في مرحلة طفولة
+
+229
+00:23:24,650 --> 00:23:29,690
+متوسطة وما يعجبهم في مرحلة طفولة متوسطة لا يعجبهم
+
+230
+00:23:29,690 --> 00:23:34,010
+في مرحلة طفولة متأخرة ما السبب في ذلك النمو العقلي
+
+231
+00:23:34,010 --> 00:23:38,450
+و الفقري و الخيالي و الإدراكي و الحسيجة للأطفال بل
+
+232
+00:23:38,450 --> 00:23:43,770
+لاحظ احنا في بعض الأحيان أطفالنا يستمعون و يشاهدون
+
+233
+00:23:43,770 --> 00:23:47,170
+فضائية أطيور جنة
+
+234
+00:23:50,960 --> 00:23:57,400
+يصرون على الاستماع والمشاهدة ولكن عندما ينمو الطفل
+
+235
+00:23:57,400 --> 00:24:00,480
+في مارحة طفولة متوسطة نجد أن هذا الاهتمام يقل
+
+236
+00:24:00,480 --> 00:24:05,580
+ويتجه هذا الاهتمام نحو شئ أدب أو نوع من أنواع
+
+237
+00:24:05,580 --> 00:24:10,700
+الأدب الأخرى وبالتالي كلما ازداد النمو لدى الأطفال
+
+238
+00:24:11,280 --> 00:24:14,660
+سواء كان نمو فكري أو خيالي أو معرفي أو إدراكي أو
+
+239
+00:24:14,660 --> 00:24:18,660
+حسي لابد أن يعكس ذلك على اختيارهم للوسائل
+
+240
+00:24:18,660 --> 00:24:25,520
+التعبيرية التي يستخدمها الأدب في ذلك وأدب الطفل
+
+241
+00:24:25,520 --> 00:24:32,000
+لايعرف الثبات وبالتالي لابد أن يمتد إلى ما وراء
+
+242
+00:24:32,000 --> 00:24:40,540
+حدود الواقع وهذا يحدث للطفولة المتأخرة خاصةأدب
+
+243
+00:24:40,540 --> 00:24:45,620
+الطفل من خصائصه لابد أن يعكس ويواكب تطورات الحياة
+
+244
+00:24:45,620 --> 00:24:51,640
+من خصائص أدب الطفل أيضًا لابد أن يحقق الاستجابة
+
+245
+00:24:51,640 --> 00:24:56,020
+والإثارة للأطفال لابد أن يجلب انتباه الطفل لابد أن
+
+246
+00:24:56,020 --> 00:25:03,020
+يشعر الطفل اتجاهه بالقبول والمحبة في هذا الجانب
+
+247
+00:25:03,020 --> 00:25:10,280
+لذلك نجد هنا أن من خلال هذه المحاضرةتحدثنا عن
+
+248
+00:25:10,280 --> 00:25:15,940
+أهمية أدب أدب الطفل يعني معنى ذلك لابد لمن يكتب
+
+249
+00:25:15,940 --> 00:25:21,500
+للأطفال أو يدرس مساق أدب الأطفال هنا أن يعرف أهمية
+
+250
+00:25:21,500 --> 00:25:29,500
+الأدب بالنسبة للطفل لأن أدب الأطفال يتمتع بخصائص
+
+251
+00:25:29,500 --> 00:25:36,450
+لابد أن تنسجم مع طبيعةالنمو الفكري و العقلي و
+
+252
+00:25:36,450 --> 00:25:39,190
+الإدراكي و الحسوس عند الطفل لابد أن نسجب مع
+
+253
+00:25:39,190 --> 00:25:44,070
+مستويات الطفولة اللي هناخدها فيما بعد الطفولة
+
+254
+00:25:44,070 --> 00:25:51,710
+المبكرة و الطفولة المتوسطة و الطفولة المتأخرة لذلك
+
+255
+00:25:51,710 --> 00:26:01,970
+نجد هنا أن أدب الطفل لابد أن يتضح مفهومه و خصائصه
+
+256
+00:26:01,970 --> 00:26:11,280
+و أهميتهوبالتالي هنا المحاضرة القادمة سنبدأ الحديث
+
+257
+00:26:11,280 --> 00:26:18,940
+عن مراحل الطفولة بمعنى أنه أدب ومراحل الطفولة
+
+258
+00:26:18,940 --> 00:26:22,640
+سنبدأ ان شاء الله تعالى في مراحل الطفولة الأولى
+
+259
+00:26:22,640 --> 00:26:28,740
+اللى يسموها مرحل الطفولة من 1 ل 3 سنوات المهن وبعد
+
+260
+00:26:28,740 --> 00:26:33,500
+ذلك ان شاء الله تعالى مرحل الطفولةالثانية المبكرة
+
+261
+00:26:33,500 --> 00:26:37,220
+الثانية في مبكرة أولى ومبكرة ثانية ناخد أنه ثانية
+
+262
+00:26:37,220 --> 00:26:41,220
+كذلك و نركز عليها وبالتالي محاضرتنا ان شاء الله
+
+263
+00:26:41,220 --> 00:26:46,700
+تعالى ستتم التركيز على أول مرحلة مراحل الطفولة و
+
+264
+00:26:46,700 --> 00:26:51,140
+هي مرحلة الطفولة الأولى من مرحل سنة إلى تالت سنوات
+
+265
+00:26:51,140 --> 00:26:55,180
+ثم ننتقل بعد ذلك إلى مرحلة الطفولة المبكرة للطفولة
+
+266
+00:26:55,180 --> 00:27:00,540
+الثانية من تالت إلى ست سنواتمرة ثانية بأكد أن
+
+267
+00:27:00,540 --> 00:27:04,720
+الكتاب المقرر علينا هو نص الأدبي لأطفال اللي هنا
+
+268
+00:27:04,720 --> 00:27:10,620
+أهدافه مصادره سيماته روي الإسلامي وهو الدكتور سعد
+
+269
+00:27:10,620 --> 00:27:15,640
+أبو أرضاوإن شاء الله تعالى في محاضرة قادمة سنحدد
+
+270
+00:27:15,640 --> 00:27:19,440
+كيفية توزيع الدرجات ونبدأ إن شاء الله تعالى في
+
+271
+00:27:19,440 --> 00:27:24,280
+تحديد التكاليف المطلوبة بالنسبة لكل طالب أو طالبة
+
+272
+00:27:24,280 --> 00:27:28,860
+في هذا المجال أرجو في محاضرة قادمة الاستعداد
+
+273
+00:27:28,860 --> 00:27:34,230
+والتحضير لما يتعلق بمراحل الطفولة سنبدأ في المرحلة
+
+274
+00:27:34,230 --> 00:27:38,770
+الأولى الطفولة الأولى اللى هو ما يتعلق بالطفولة
+
+275
+00:27:38,770 --> 00:27:43,950
+الأولى و ثم بعد ذلك الطفولة الثانية و نبدأ بعد ذلك
+
+276
+00:27:43,950 --> 00:27:50,030
+في المراحل الأخرى و كما قلت سابقا انه سيكون هناك
+
+277
+00:27:50,030 --> 00:27:56,750
+جانب تطبيقي واسع المساق يعتمد على جانب نظري قنظيري
+
+278
+00:27:56,750 --> 00:27:59,310
+و هو حيث سيكون في البداية ان ش الله تعالى و بعد
+
+279
+00:27:59,310 --> 00:28:06,750
+ذلك سيكون لدينا نصوصمسرحية و قصصية و شعرية يتم من
+
+280
+00:28:06,750 --> 00:28:11,230
+خلالها و أنا شيل يتم من خلالها فهم الجانب التطبيقى
+
+281
+00:28:11,230 --> 00:28:15,830
+و مزج الجانب النظري بالجانب التطبيقى هذا و بالله
+
+282
+00:28:15,830 --> 00:28:20,890
+التوفيق والسلام عليكم ورحمة الله وبركاته
+
diff --git a/PL9fwy3NUQKwYT4Ayhm-3qTiT1ILbX-hwD/v-flFWVnvqg.srt b/PL9fwy3NUQKwYT4Ayhm-3qTiT1ILbX-hwD/v-flFWVnvqg.srt
new file mode 100644
index 0000000000000000000000000000000000000000..f2cecf77055593c9cdefbb624ef4710be66b79f3
--- /dev/null
+++ b/PL9fwy3NUQKwYT4Ayhm-3qTiT1ILbX-hwD/v-flFWVnvqg.srt
@@ -0,0 +1,681 @@
+1
+00:00:01,450 --> 00:00:05,930
+بسم الله الرحمن الرحيم بداية نرحب بطلاب وطالبات
+
+2
+00:00:05,930 --> 00:00:10,890
+مساق أدب الطفل ونسأل الله سبحانه وتعالى السلام
+
+3
+00:00:10,890 --> 00:00:17,010
+والتوفيق للجميع، المساق الذي بين أيدينا في هذه...
+
+4
+00:00:17,010 --> 00:00:25,010
+في هذا الفصل، مساق أدب الطفل، لابد بداية أن نتعرف
+
+5
+00:00:25,010 --> 00:00:32,540
+على مفهوم الأدب، مفهوم الثقافة، لأن في الكتاب أول
+
+6
+00:00:32,540 --> 00:00:36,500
+عنوان في الفصل الأول: أدب والثقافة، فده بده أن نشرح
+
+7
+00:00:36,500 --> 00:00:40,120
+ما المقصود بالأدب؟ وما المقصود بالثقافة؟ وطبيعة
+
+8
+00:00:40,120 --> 00:00:43,780
+العلاقات التي تربط الثقافة بالأدب، بداية نقول أن
+
+9
+00:00:43,780 --> 00:00:50,120
+المفهوم السائد قديمًا لمفردة الأدب كان مفهومًا حسيًا
+
+10
+00:00:50,120 --> 00:00:55,800
+ماديًا، يقصد به دعوة إلى الطعام، لا أريد التوسع في
+
+11
+00:00:55,800 --> 00:01:02,970
+هذا الجانب، ثم بعد ذلك، تطور هذا المفهوم فأصبح
+
+12
+00:01:02,970 --> 00:01:08,350
+يُقصد به أو أخذ بعدًا أخلاقيًا، لذلك قال النبي صلى
+
+13
+00:01:08,350 --> 00:01:16,370
+الله عليه وسلم: "أدبني ربي فأحسن تأديبي"، ثم
+
+14
+00:01:16,370 --> 00:01:22,530
+بعد ذلك، انتقل وتطور هذا المفهوم وأصبح يقصد به كلام
+
+15
+00:01:22,530 --> 00:01:28,630
+الجميل المؤثر الذي يعبر فيه الأديب عن أحاسيسه وعن
+
+16
+00:01:28,630 --> 00:01:34,290
+انفعالاته وعن عواطفه وعن أفكاره، ويحدث هذا الكلام
+
+17
+00:01:34,290 --> 00:01:40,610
+الجميل أثرًا ومتعة في نفوس السامعين، سواء كان هذا
+
+18
+00:01:40,610 --> 00:01:49,130
+الكلام شعرًا أم نثرًا، وبالتالي لو قلنا: أدب الطفل،
+
+19
+00:01:49,970 --> 00:01:54,130
+منهم من عرفوا هذا الأدب أنه الكلام الجميل الذي
+
+20
+00:01:54,130 --> 00:02:01,590
+يحدث تأثيرًا في نفس الأطفال ويحدث متعة فنية، وهذا
+
+21
+00:02:01,590 --> 00:02:08,350
+الكلام سواء كان شعرًا أو نثرًا هو المادة الأساسية
+
+22
+00:02:08,350 --> 00:02:14,970
+للأدب، وصناعة وشكيل الأدب هي اللغة، فلابد لمن يكتب
+
+23
+00:02:14,970 --> 00:02:21,930
+الأدب أن يمتلك اللغة، ولكن السؤال: هل لكل من يسمع
+
+24
+00:02:21,930 --> 00:02:25,710
+الأدب أن يمتلكوا اللغة؟ نقول: يفضل الكبار يمتلكون
+
+25
+00:02:25,710 --> 00:02:30,650
+اللغة، ولكن الصغار في مرحلة المهد وربما يمتد إلى
+
+26
+00:02:30,650 --> 00:02:35,050
+مرحلة الطفولة المبكرة لا يمتلكون اللغة، وبالتالي
+
+27
+00:02:35,050 --> 00:02:41,170
+يحدث هناك وسائل تعبيرية أخرى كالصورة أو الموسيقى
+
+28
+00:02:41,170 --> 00:02:46,530
+أو نتحدث عن فيما يتعلق بالصورة الصامتة أو المتحركة
+
+29
+00:02:46,530 --> 00:02:52,010
+أو فيما يتعلق بالتجسيد الألفاظ عبر قوالب حسية
+
+30
+00:02:52,010 --> 00:02:57,270
+يستطيع الطفل أن يفهمها، وهذه قوالب مستقاة من بيئة
+
+31
+00:02:57,270 --> 00:03:01,050
+الطفل، إذًا مفهوم الأدب لابد أن نعرف أن
+
+32
+00:03:01,050 --> 00:03:05,910
+الأدب ولغة الأدب تختلف عن اللغة التداولية بين
+
+33
+00:03:05,910 --> 00:03:11,370
+الناس، وجه الاختلاف يقيم في أن الأدب يحمل في داخله
+
+34
+00:03:11,370 --> 00:03:19,360
+قيمًا فنية وجمالية تحدث تأثيرًا في نفس المتلقي، إضافة
+
+35
+00:03:19,360 --> 00:03:23,000
+إلى ذلك أن الأدب لا يتعامل مع الأشياء تعاملًا
+
+36
+00:03:23,000 --> 00:03:33,860
+مباشرًا، وإنما تعاملًا مجازيًا، إيحائيًا، رمزيًا، الثقافة
+
+37
+00:03:33,860 --> 00:03:41,840
+إذًا ما عدنا إلى مفهوم الثقافة، عرفها Edward Tylor
+
+38
+00:03:42,530 --> 00:03:47,590
+في كتابه، في كتابه "الثقافة البدائية"، قال أن
+
+39
+00:03:47,590 --> 00:03:52,010
+الثقافة عبارة عن ماذا؟ قال: عبارة عن مُركّب، وهذا
+
+40
+00:03:52,010 --> 00:03:56,250
+المُركّب يجتمل على ماذا؟ قال: يجتمل على المعرفة
+
+41
+00:03:56,250 --> 00:04:02,910
+والعقائد والفن والأخلاق والقانون والعدة والقدرات
+
+42
+00:04:02,910 --> 00:04:10,530
+التي يكتسبها الإنسان، يكتسبها الإنسان بوصفه داخل
+
+43
+00:04:10,530 --> 00:04:17,720
+مجتمع، بوصفه عضوًا داخل المجتمع، وبالتالي الثقافة
+
+44
+00:04:17,720 --> 00:04:26,980
+ليست واحدة، تتباين حسب تباين واختلاف المجتمعات، طب
+
+45
+00:04:26,980 --> 00:04:31,680
+يقول لنا هنا أقسام الثقافة، منهم من قسم الثقافة إلى
+
+46
+00:04:31,680 --> 00:04:36,500
+ثلاث أقسام: عموميات، هذا القسم الأول، القسم الثاني
+
+47
+00:04:36,500 --> 00:04:43,160
+الخصوصيات، القسم الثالث: البدائل، ما المقصود بالقسم
+
+48
+00:04:43,160 --> 00:04:46,940
+الأول: العموميات، يعني هذا عمليات، من عنوانه أنه عام
+
+49
+00:04:46,940 --> 00:04:55,500
+يشترك فيه مجتمعات متعددة، بمعنى أن أنماط السلوك
+
+50
+00:04:55,500 --> 00:05:00,520
+والجوانب الحتمية، كل لغة الأسرة موجودة في كل مجتمع
+
+51
+00:05:00,520 --> 00:05:10,850
+الخصوصيات: ما يتميز به مجتمع أو قطاع في داخل المجتمع
+
+52
+00:05:10,850 --> 00:05:17,930
+عن مجتمع أو قطاع آخر، زي ما إحنا في هناك اختلاف
+
+53
+00:05:17,930 --> 00:05:26,030
+وخصيصة لكل لهجة في بيئة معينة، وبالتالي المقصود
+
+54
+00:05:26,030 --> 00:05:30,250
+بالخصوصيات ما يتميز به قطاع معين من قطاعات
+
+55
+00:05:30,250 --> 00:05:37,900
+المجتمع من تميز ثقافي أو فكري، والمقصود بالنوع
+
+56
+00:05:37,900 --> 00:05:45,000
+الثالث، القسم الثالث: البدائل، أي أن هناك ثقافة
+
+57
+00:05:45,000 --> 00:05:53,120
+تتسلل إلى المجتمع عبر الاحتكاك مع ثقافات أخرى، عبر
+
+58
+00:05:53,120 --> 00:05:56,680
+الاحتكاك، وبالتالي بدائل يعني هناك ثقافة بديلة
+
+59
+00:05:56,680 --> 00:06:02,820
+وأكبر دليل على ذلك عندما يتابع الطفل الثقافة
+
+60
+00:06:02,820 --> 00:06:09,330
+الغربية غير المحلية عبر شاشات التلفاز أو عبر أجهزة
+
+61
+00:06:09,330 --> 00:06:13,850
+الحاسوب أو عبر ربما الأشياء المقبوعة أو المرسومة
+
+62
+00:06:13,850 --> 00:06:17,190
+الأشياء
+
+63
+00:06:17,190 --> 00:06:25,490
+المقبوعة أو المرسومة، هناك نقطة أخرى: ثقافة الأطفال،
+
+64
+00:06:25,490 --> 00:06:30,290
+ثقافة نوعية متصلة مع ثقافة المجتمع وليس منفصلة
+
+65
+00:06:30,290 --> 00:06:37,460
+عنها، فهي جزء لا يتجزأ من ثقافة المجتمع، وتشترك إحنا
+
+66
+00:06:37,460 --> 00:06:42,940
+قلنا هناك خصيصة لثقافة الطفل وهي متصلة مع ثقافة
+
+67
+00:06:42,940 --> 00:06:47,860
+المجتمع، أي مع ثقافة الكبار، ولكنها ليست منفصلة عنها،
+
+68
+00:06:47,860 --> 00:06:55,000
+ومن هنا نجد أن ثقافة الأطفال تنفرد بخصائص تتميز
+
+69
+00:06:55,000 --> 00:07:01,220
+وتختلف فيها عن ثقافة الكبار، لذلك نجد في ثقافة
+
+70
+00:07:01,220 --> 00:07:05,380
+الصغار معايير غير موجودة في ثقافة الكبار، كاللعب،
+
+71
+00:07:07,040 --> 00:07:15,140
+وكذلك الرسومات، كذلك أشكال العروض المختلفة، لذلك نجد
+
+72
+00:07:15,140 --> 00:07:19,560
+أيضًا في داخل ثقافات الأطفال تباين، لأن الأطفال
+
+73
+00:07:19,560 --> 00:07:24,640
+ليسوا على مستوى واحد من الفكر والثقافة، إنما هناك
+
+74
+00:07:24,640 --> 00:07:31,960
+ثقافات متباينة، لذلك عندما نقول أن ثقافة الطفل
+
+75
+00:07:31,960 --> 00:07:34,860
+أساسية،
+
+76
+00:07:35,220 --> 00:07:40,700
+ولكن ينبغي أن تكون من داخل المجتمع، طب نقول هنا
+
+77
+00:07:40,700 --> 00:07:47,020
+الأدب والثقافة، طبيعة العلاقة بينهما سنقول أن هناك
+
+78
+00:07:47,020 --> 00:07:51,620
+علاقة وطيدة بين الثقافة والأدب، فالأدب يعبر عن
+
+79
+00:07:51,620 --> 00:07:57,400
+ثقافة المجتمع، الأدب يعبر عن ثقافة الأفراد
+
+80
+00:07:57,400 --> 00:08:03,060
+والجماعات، الأدب وسيلة من وسائل التعبير عن الثقافة،
+
+81
+00:08:03,420 --> 00:08:08,740
+ولكن ليس هو الوسيلة الوحيدة، التاريخ يعبر عن
+
+82
+00:08:08,740 --> 00:08:14,280
+الثقافة، الأدب يعبر عن الثقافة، الاجتماعيات يعبر عن
+
+83
+00:08:14,280 --> 00:08:17,580
+الثقافة، الفلسفة، علم النفس يعبر عن ثقافة المجتمع،
+
+84
+00:08:17,580 --> 00:08:27,780
+ومن هنا أقول أن الثقافة تُجسّد عبر اللغة، ولغة الأدب
+
+85
+00:08:29,200 --> 00:08:34,580
+لها سماتها الفنية والجمالية التي تجذب اهتمام الطفل،
+
+86
+00:08:34,580 --> 00:08:41,840
+وتشبع رغبات الطفل، إذًا المعنى ذلك لابد أن نقول أن
+
+87
+00:08:41,840 --> 00:08:51,440
+اللغة قد تتجسد عبر صورة أو صوت أو لون أو رسومات أو
+
+88
+00:08:51,440 --> 00:08:58,420
+حركة أو صورة ناطقة، متحركة أو صامتة، إذًا المعنى ذلك
+
+89
+00:08:58,420 --> 00:09:07,200
+هناك تجسيد، طب لو سألنا هنا، لو سألنا: لغة
+
+90
+00:09:07,200 --> 00:09:12,460
+الأطفال لابد أن تتناسب مع مستوياتهم، يعني المعنى
+
+91
+00:09:12,460 --> 00:09:17,600
+ذلك، اللغة المجسدة لثقافة الطفل لابد أن تنتقل من
+
+92
+00:09:17,600 --> 00:09:23,320
+مرحلة التجريد إلى مرحلة التجسيد، التجريد يعني كلام
+
+93
+00:09:23,320 --> 00:09:28,430
+مسموع، التجسيد: بدي أحط هذا الكلام عبر لغة، عبر صورة،
+
+94
+00:09:28,430 --> 00:09:33,530
+عبر صوت، عبر حركة، عبر رسومات، بجسّدها، بقربها، يعني
+
+95
+00:09:33,530 --> 00:09:39,270
+بستخدم أشياء حسية من واقع الطفل، بوظفها من أجل أن
+
+96
+00:09:39,270 --> 00:09:47,490
+أعبر عن الأدب، وبالتالي لو قلنا هنا: أدب الطفل،
+
+97
+00:09:47,490 --> 00:09:54,910
+لابد أن يستخدم وسائل التجسيد الفني، طيب لماذا لغة
+
+98
+00:09:54,910 --> 00:09:59,590
+الأدب، لغة أدب الطفل، الأطفال تختلف عن لغة أدب الكبار،
+
+99
+00:09:59,590 --> 00:10:05,690
+هذا شيء معروف، ولكن التخييل الفني في أدب الطفل ما
+
+100
+00:10:05,690 --> 00:10:11,010
+الفائدة منه؟ أول شيء: أنه يتيح للعمليات العقلية
+
+101
+00:10:11,010 --> 00:10:18,290
+المعرفية أن تؤدي دورها في إثراء وإمتاع وجدان الطفل،
+
+102
+00:10:21,910 --> 00:10:26,730
+لأن الطفل يكون شديد الاستجابة لعناصر التجسيد
+
+103
+00:10:26,730 --> 00:10:33,170
+اللغوية وغير اللغوية، يتفاعل معها، ينسجم معها، الشيء
+
+104
+00:10:33,170 --> 00:10:38,830
+الثاني: أن التجسيد من العوامل التي تثري عمل التخيل
+
+105
+00:10:38,830 --> 00:10:45,050
+الطفل، يتخيل الصورة المركبة، وهذا التجسيد الذي يغذي
+
+106
+00:10:45,050 --> 00:10:50,870
+التخيل، يتيح المجال للتوسع والتعمق في إدراك
+
+107
+00:10:50,870 --> 00:10:57,220
+المعنى، إدراك الطفل للمعنى عبر التخيل يكون أكثر دقة
+
+108
+00:10:57,220 --> 00:11:04,040
+وإثراءً وإشباعًا لرغبة الطفل، الشيء الثالث: أن التجسيد
+
+109
+00:11:04,040 --> 00:11:11,340
+الفني يعزز عملية الاتصال الثقافي، يثري فعالية العمل
+
+110
+00:11:11,340 --> 00:11:18,960
+الأدبي، وبذلك التجسيد الفني من خلاله نستطيع أن
+
+111
+00:11:18,960 --> 00:11:26,680
+نتجاوز عملية الاتصال التقليدية اللي هي التلقين إلى
+
+112
+00:11:26,680 --> 00:11:31,900
+وسائل بعيدة عن التقريرية، تصبح وسائل فيها نوع من
+
+113
+00:11:31,900 --> 00:11:36,780
+أنواع الإيحاء والإبداع، كذلك التخييل، الفن يقرب
+
+114
+00:11:36,780 --> 00:11:42,600
+المفاهيم ويضعها في صور وقوالب حسية، سواء كان عن
+
+115
+00:11:42,600 --> 00:11:47,860
+طريق اللون أو الصوت أو الحركة أو الصورة المتحركة
+
+116
+00:11:47,860 --> 00:11:52,050
+أو الصامتة أو أشياء أخرى، إذًا المعنى ذلك التخييل
+
+117
+00:11:52,050 --> 00:11:57,830
+الفني يقرب المفاهيم المعنوية المجردة ويضعها في
+
+118
+00:11:57,830 --> 00:12:04,910
+قالب حسي لكي يدركها الطفل، مثلًا لما نقول للطفل: ما
+
+119
+00:12:04,910 --> 00:12:08,950
+المقصود بالشجاعة؟ بيعرفش، ما يقدرش يعبر عنها، بس إذا جِبنا له
+
+120
+00:12:08,950 --> 00:12:12,550
+رسمًا أو صورة متحركة تعبر عن شجاعة، يستطيع أن يفهمها،
+
+121
+00:12:12,550 --> 00:12:16,590
+لما نقول له: يا طفل تعاون، لا يستطيع أن يفهم ما
+
+122
+00:12:16,590 --> 00:12:20,890
+المقصود بالتعاون كمصطلح، ولكن نجيب له صورة فيها
+
+123
+00:12:20,890 --> 00:12:24,810
+أطفال بتعاون مع بعضهم، يستطيع أن يفهم ذلك، لما نقول
+
+124
+00:12:24,810 --> 00:12:29,190
+له: هو الصدق، المقصود بالصدق كمفهوم مش هيعرف، بس نجيب
+
+125
+00:12:29,190 --> 00:12:32,930
+له صورة تعبر عن إنسان صادق وإنسان كذاب، أو إنسان
+
+126
+00:12:32,930 --> 00:12:38,180
+أمين وإنسان غير أمين، عبر قصة، عبر رسوم، عبر صور، عبر
+
+127
+00:12:38,180 --> 00:12:43,900
+مشهد كارتون، عبر صور متحركة، أشياء كثيرة، لذلك هنا
+
+128
+00:12:43,900 --> 00:12:50,420
+نقول أيضًا أن الكلمة في حد ذاتها فيها قوة أثرية
+
+129
+00:12:50,420 --> 00:12:55,880
+لأنها صوت، والصوت يسمعه الطفل، لذلك تعتبر الكلمة
+
+130
+00:12:55,880 --> 00:13:02,820
+لبنة في سياق فني، بس تستقبل الكلمة عبر حاسة السمع
+
+131
+00:13:02,820 --> 00:13:11,930
+وتُطِير في ذهن الطفل ماذا؟ صور، كذلك أن التجسيد أو
+
+132
+00:13:11,930 --> 00:13:17,290
+اللغة المجسدة لثقافة الطفل لابد أن يصاحبها ألوان
+
+133
+00:13:17,290 --> 00:13:23,030
+وصور ورسومات وحركات لهذه الكلمات، لأن الطفل يميل
+
+134
+00:13:23,030 --> 00:13:27,950
+إلى الكلمات التي يصاحبها ألوان وصور ورسوم وحركات،
+
+135
+00:13:27,950 --> 00:13:34,150
+لأن هذا يثير اهتمام الطفل، يثير اهتمام الطفل، فالصورة
+
+136
+00:13:34,150 --> 00:13:38,850
+تنطبع في أذهان الأطفال، وانطباع الصورة أو الصوت أو
+
+137
+00:13:38,850 --> 00:13:45,630
+الحركة يغذي الفهم عند الطفل ويعزز من فعالية تأثيره
+
+138
+00:13:45,630 --> 00:13:52,830
+عند الطفل، لذلك الكتاب المصور يحقق التوازن بين النص
+
+139
+00:13:52,830 --> 00:13:53,450
+والصورة،
+
+140
+00:13:55,950 --> 00:14:00,550
+فلذلك نجد هنا، إضافة إلى الصورة، يكون هنا تعليم في
+
+141
+00:14:00,550 --> 00:14:04,230
+تمتع بالصورة أو بجزء من الصورة التي تكون في داخل
+
+142
+00:14:04,230 --> 00:14:09,730
+قصة أو في داخل قصيدة، فالصور الملونة في داخل القصص
+
+143
+00:14:09,730 --> 00:14:12,430
+والكتب الورقية مهمة جدًا، إضافة إلى ذلك، الصورة
+
+144
+00:14:12,430 --> 00:14:17,410
+الملونة عبر وسائل التكنولوجيا الحديثة مهمة، ومن هنا
+
+145
+00:14:17,410 --> 00:14:22,970
+الأطفال لا يستطيعون قراءة معنى الصورة بدون أي كلمة،
+
+146
+00:14:22,970 --> 00:14:28,590
+فالكلمات تعزز الصورة، والصورة تعزز الكلمات، لذلك
+
+147
+00:14:28,590 --> 00:14:34,570
+تعتبر هنا الحركات لونًا يُضاف إلى جمال الصورة، لونًا
+
+148
+00:14:34,570 --> 00:14:41,230
+يُضاف إلى جمال الصورة، ومن هنا نقول أن اعتماد الصورة
+
+149
+00:14:41,230 --> 00:14:47,730
+مهم جدًا، ولكن أكثر منها قد يحد من نمو الطفل، إذا
+
+150
+00:14:47,730 --> 00:14:51,370
+لم يكن هناك جوانب تفتح هذه الأبواب أمام الطفل، لذلك
+
+151
+00:14:51,370 --> 00:14:56,730
+أدب الطفل عندما يُقدم للأطفال لابد أن يُقدم بلغة
+
+152
+00:14:56,730 --> 00:15:03,230
+تتناسب مع طبيعة تفكير الأطفال، مع طبيعة فهم الأطفال،
+
+153
+00:15:03,230 --> 00:15:08,810
+وكذلك لابد أن يعزز أدب الطفل بالتخييل الفني، لأن
+
+154
+00:15:08,810 --> 00:15:13,670
+التخييل الفني يقرب المعنويات ويضعها في قالب حسي
+
+155
+00:15:13,670 --> 00:15:21,620
+يستطيع الطفل أن يفهمها، لذلك نقول هنا أن أدب الطفل
+
+156
+00:15:21,620 --> 00:15:28,960
+لابد أن يعزز من توسع الخيال عند الأطفال، وبالتالي
+
+157
+00:15:28,960 --> 00:15:34,900
+نقول هنا أن اللغة المجسدة لثقافة الأطفال مهمة جدًا،
+
+158
+00:15:34,900 --> 00:15:42,520
+لأنها تقرب لهم الأشياء المجردة، غير المحسوسة، تُدرّك
+
+159
+00:15:42,520 --> 00:15:48,700
+في القلب الحسي، والطفل إذا وُضِعَ الأدب عبر، أو تم التعبير
+
+160
+00:15:48,700 --> 00:15:54,780
+عن الأدب في لغة تُجسّد المعنى، استطاع الطفل أن يفهم
+
+161
+00:15:54,780 --> 00:16:02,060
+ذلك، لذلك لا تكون هناك وسيلة واحدة من وسائل التعبير
+
+162
+00:16:02,060 --> 00:16:09,960
+عن الأدب، قد يُعبّر بالصوت أو بالصورة أو بالرسومات أو
+
+163
+00:16:09,960 --> 00:16:16,200
+يُعبّر بالصورة المسموعة أو بالصورة المتحركة الحية أو
+
+164
+00:16:16,200 --> 00:16:22,920
+الصورة الصامتة، لذلك ينبغي على من يُعلّم الأدب للأطفال
+
+165
+00:16:22,920 --> 00:16:29,940
+أن يختار اللغة التي تناسب الطفل، لأن الأطفال ليس
+
+166
+00:16:29,940 --> 00:16:36,340
+لديهم مرحلة واحدة فقط، إنما هناك مراحل ومستويات
+
+167
+00:16:36,340 --> 00:16:41,620
+لنمو الأطفال، ومن هنا لابد أن نعرف احتياجات الطفل
+
+168
+00:16:41,620 --> 00:16:45,900
+ومستويات الفكر والثقافة والخلفية للأطفال، حتى نستطيع
+
+169
+00:16:45,900 --> 00:16:51,000
+أن نبحث عن وسائل أكثر تأثيرًا، الوسائل التي يُعبّر بها
+
+170
+00:16:51,000 --> 00:16:55,420
+الأديب عن أدبه الأكثر تأثيرًا في الطفل والأكثر
+
+1
\ No newline at end of file
diff --git a/PL9fwy3NUQKwYT4Ayhm-3qTiT1ILbX-hwD/v-flFWVnvqg_postprocess.srt b/PL9fwy3NUQKwYT4Ayhm-3qTiT1ILbX-hwD/v-flFWVnvqg_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..c9e1377eb4cd9579efc16583fbfead01a3302278
--- /dev/null
+++ b/PL9fwy3NUQKwYT4Ayhm-3qTiT1ILbX-hwD/v-flFWVnvqg_postprocess.srt
@@ -0,0 +1,820 @@
+1
+00:00:01,450 --> 00:00:05,930
+بسم الله الرحمن الرحيم بداية نرحب بطلاب وطالبات
+
+2
+00:00:05,930 --> 00:00:10,890
+مساق أدب الطفل ونسأل الله سبحانه وتعالى السلام
+
+3
+00:00:10,890 --> 00:00:17,010
+والتوفيق للجميع المساق اللذي بين أيدينا في هذه ..
+
+4
+00:00:17,010 --> 00:00:25,010
+في هذا الفصل مساق أدب الطفل لابد بداية أن نتعرف
+
+5
+00:00:25,010 --> 00:00:32,540
+على مفهوم الأدب مفهوم الثقافة لأن في الكتابأول
+
+6
+00:00:32,540 --> 00:00:36,500
+عنوان في الفصل الأول أدب والثقافة فده بده أن نشرح
+
+7
+00:00:36,500 --> 00:00:40,120
+ما المقصود بالأدب وما المقصود بالثقافة وطبيعة
+
+8
+00:00:40,120 --> 00:00:43,780
+العلاقات التي تربط الثقافة بالأدب بداية نقول أن
+
+9
+00:00:43,780 --> 00:00:50,120
+المفهوم السائد قديما لمفردة الأدب كان مفهوما حسيا
+
+10
+00:00:50,120 --> 00:00:55,800
+ماديا يقصد به دعوة إلى الطعام لا أريد التوسع في
+
+11
+00:00:55,800 --> 00:01:02,970
+هذا الجانب ثم بعد ذلك التظورةهذا المفهوم فأصبح
+
+12
+00:01:02,970 --> 00:01:08,350
+يُقصد به أو أخذ بعد أخلاقيا لذلك قال النبي صلى
+
+13
+00:01:08,350 --> 00:01:16,370
+الله عليه وسلم أدبني ربي فأحسن تأديبي ثم
+
+14
+00:01:16,370 --> 00:01:22,530
+بعد ذلك انتقل و تطور هذا المفهوموأصبح يقصد به كلام
+
+15
+00:01:22,530 --> 00:01:28,630
+الجميل المؤثر الذي يعبر فيه الأذيب عن أحاسيسه وعن
+
+16
+00:01:28,630 --> 00:01:34,290
+انفعالاته وعن عواطفه وعن أفكاره ويحدث هذا الكلام
+
+17
+00:01:34,290 --> 00:01:40,610
+الجميل أثرا ومتعة في نفوس السمعين سواء كان هذا
+
+18
+00:01:40,610 --> 00:01:49,130
+الكلام شعرا أم نترا وبالتالي لو قلنا الأدب الطفل
+
+19
+00:01:49,970 --> 00:01:54,130
+منهم من عرفوا هذا الأدب أنه الكلام الجميل الذي
+
+20
+00:01:54,130 --> 00:02:01,590
+يحدث تأثيرا في نفس الأطفال ويحدث متعة فنية وهذا
+
+21
+00:02:01,590 --> 00:02:08,350
+الكلام سواء كان شعرا او نثرا هو المادة الأساسية
+
+22
+00:02:08,350 --> 00:02:14,970
+للأدب وصناعة وشكيل الأدب هي اللغة فلابد لمن يكتب
+
+23
+00:02:14,970 --> 00:02:21,930
+الأدب أن يمتلك اللغةولكن السؤال هل لكل من يسمع
+
+24
+00:02:21,930 --> 00:02:25,710
+الأدب أن يمتلكوا اللغة نقول يفضل الكبار يمتلكون
+
+25
+00:02:25,710 --> 00:02:30,650
+اللغة ولكن الصغار في مراحة المهد وربما يمتد إلى
+
+26
+00:02:30,650 --> 00:02:35,050
+مراحة الطفولة المبكرة لا يمتلكون اللغة وبالتالي
+
+27
+00:02:35,050 --> 00:02:41,170
+يحدث هناك وسائل تعبيرية أخرى كالصورة أو الموسيقى
+
+28
+00:02:41,170 --> 00:02:46,530
+أو نتحدث عنفيما يتعلق بالصورة الصامت أو المتحركة
+
+29
+00:02:46,530 --> 00:02:52,010
+أو فيما يتعلق بالتجسيد الألفاظ عبر قوالب حسية
+
+30
+00:02:52,010 --> 00:02:57,270
+يستطيع الطفل أن يفهمها و هذه قوالب مستقاة من بيئة
+
+31
+00:02:57,270 --> 00:03:01,050
+الطفل إذا المعنى ذات مفهوم الأدب لابد أن نعرف أن
+
+32
+00:03:01,050 --> 00:03:05,910
+الأدب و لغة الأدب تختلف عن اللغة التداولية بين
+
+33
+00:03:05,910 --> 00:03:11,370
+الناس وجه الاختلاف يقمن في أن الأدب يحمل في داخله
+
+34
+00:03:11,370 --> 00:03:19,360
+قيمفنية وجمالية تحدث تأثيرا في وجهها المتلقي إضافة
+
+35
+00:03:19,360 --> 00:03:23,000
+إلى ذلك أن الأدب لا يتعامل مع الأشياء تعاملا
+
+36
+00:03:23,000 --> 00:03:33,860
+مباشرا وإنما تعاملا مجازيا إيحائيا رمزيا الثقافة
+
+37
+00:03:33,860 --> 00:03:41,840
+إذا ما عدنا إلى مفهوم الثقافة عرفها Edward Taylor
+
+38
+00:03:42,530 --> 00:03:47,590
+في داخل كتاب في كتابه الثقافة البدائية قال أن
+
+39
+00:03:47,590 --> 00:03:52,010
+الثقافة عبارة عن ماذا؟ قال عبارة عن مُركّب وهذا
+
+40
+00:03:52,010 --> 00:03:56,250
+المُركّب يجتمل على ماذا؟ قال يجتمل على المعرفة
+
+41
+00:03:56,250 --> 00:04:02,910
+والعقائل والفن والأخلاق والقانون والعداد والقدرات
+
+42
+00:04:02,910 --> 00:04:10,530
+التي يكتسبها الإنسان يكتسبها الإنسان بوصفه داخل
+
+43
+00:04:10,530 --> 00:04:17,720
+مجتمعبوصفه عضوًا داخل المجتمع وبالتالي الثقافة
+
+44
+00:04:17,720 --> 00:04:26,980
+ليست واحدة تتبين حسب تباين واختلاف المجتمعات طب
+
+45
+00:04:26,980 --> 00:04:31,680
+يقولنا هنا أقسام الثقافة منهم ان قسم الثقافة إلى
+
+46
+00:04:31,680 --> 00:04:36,500
+ثلاث أقسام عموميات هذا قسم الأول القسم الثاني
+
+47
+00:04:36,500 --> 00:04:43,160
+الخصوصيات القسم الثالث البديلاتما المقصود بالقسم
+
+48
+00:04:43,160 --> 00:04:46,940
+الأول العمليات يعني هذا عمليات من عنوانه أنه عام
+
+49
+00:04:46,940 --> 00:04:55,500
+يشترك بينها مجتمعات متعددة بمعنى أن أنماط السلوك
+
+50
+00:04:55,500 --> 00:05:00,520
+والجوانب الحتمية كل لغة الأسرة موجودة في كل مجتمع
+
+51
+00:05:00,520 --> 00:05:10,850
+الخصيات ما يتميز به مجتمع أو قطاعفي داخل المجتمع
+
+52
+00:05:10,850 --> 00:05:17,930
+عن مجتمع او قطاع اخر زي ما احنا في هناك اختلاف
+
+53
+00:05:17,930 --> 00:05:26,030
+وخصية لكل لهجة في بيئة معينة وبالتالي المقصود
+
+54
+00:05:26,030 --> 00:05:30,250
+بالخصيات ان ما يتميز به قطاع معين من قطاعات
+
+55
+00:05:30,250 --> 00:05:37,900
+المجتمع من تميز ثقافي او فكريوالمقصود بالنوع
+
+56
+00:05:37,900 --> 00:05:45,000
+الثالث القسم الثالث البديلات أي أن هناك ثقافة
+
+57
+00:05:45,000 --> 00:05:53,120
+تتسلل إلى المجتمع عبر الاحتكاك مع ثقافات أخرى عبر
+
+58
+00:05:53,120 --> 00:05:56,680
+الاحتكاك وبالتالي بديلات يعني هناك ثقافة بديلة
+
+59
+00:05:56,680 --> 00:06:02,820
+وأكبر ذليل على ذلك عندما يتابع الطفل الثقافة
+
+60
+00:06:02,820 --> 00:06:09,330
+الغربية غير المحليةعبر شاشات التلفاز أو عبر أجهزة
+
+61
+00:06:09,330 --> 00:06:13,850
+الحسوب أو عبر ربما الأشياء المقبوعة أو المرسومة
+
+62
+00:06:13,850 --> 00:06:17,190
+الأشياء
+
+63
+00:06:17,190 --> 00:06:25,490
+المقبوعة أو المرسومة هناك نقطة أخرى ثقافة الأطفال
+
+64
+00:06:25,490 --> 00:06:30,290
+ثقافة نوعية متصلة مع ثقافة المجتمع وليس منفصلة
+
+65
+00:06:30,290 --> 00:06:37,460
+عنها فهي جزء لا يتجزأ من ثقافة المجتمعوتشترك احنا
+
+66
+00:06:37,460 --> 00:06:42,940
+قلنا هناك خصية لثقافة الطفل وهي متصلة مع ثقافة
+
+67
+00:06:42,940 --> 00:06:47,860
+المجتمع أي مع ثقافة الكبار ولكنها ليست منفصلة عنها
+
+68
+00:06:47,860 --> 00:06:55,000
+ومن هنا نجد أن ثقافة الأطفال تنفرد بخصائص تتميز
+
+69
+00:06:55,000 --> 00:07:01,220
+وتختلف فيها عن ثقافة الكبار لذلك نجد في ثقافة
+
+70
+00:07:01,220 --> 00:07:05,380
+الصغار معايير غير موجودة في ثقافة الكبار كاللعب
+
+71
+00:07:07,040 --> 00:07:15,140
+كذلك الرسومات كذلك أشكال العروض المختلفة لذلك نجد
+
+72
+00:07:15,140 --> 00:07:19,560
+أيضًا في داخل ثقافات الأطفال تباين لأن الأطفال
+
+73
+00:07:19,560 --> 00:07:24,640
+ليسوا على مستوى واحد من الفكر والثقافة إنما هناك
+
+74
+00:07:24,640 --> 00:07:31,960
+ثقافات متباينة لذلك عندما نقول أن ثقات الطفل
+
+75
+00:07:31,960 --> 00:07:34,860
+أساسية
+
+76
+00:07:35,220 --> 00:07:40,700
+ولكن ينبغي أن تكون من داخل المجتمع طب نقول هنا
+
+77
+00:07:40,700 --> 00:07:47,020
+الأدب والثقافة طبيعة العلاقة بينهما سنقول أن هناك
+
+78
+00:07:47,020 --> 00:07:51,620
+علاقة وطيدة بين الثقافة والأدب فالأدب يعبر عن
+
+79
+00:07:51,620 --> 00:07:57,400
+ثقافة المجتمع الأدب يعبر عن ثقافة الأفراد
+
+80
+00:07:57,400 --> 00:08:03,060
+والجماعات الأدب وسيلة من وسائل التعبير عن الثقافة
+
+81
+00:08:03,420 --> 00:08:08,740
+ولكن ليس هو الوسيلة الوحيدة التاريخ يعبر عن
+
+82
+00:08:08,740 --> 00:08:14,280
+الثقافة الأدب يعبر عن الثقافة الاجتماعيات يعبر عن
+
+83
+00:08:14,280 --> 00:08:17,580
+الثقافة الفلسفة علم النفس يعبر عن ثقافة المجتمع
+
+84
+00:08:17,580 --> 00:08:27,780
+ومن هنا أقول أن الثقافة تجسد عبر اللغة ولغة الأدب
+
+85
+00:08:29,200 --> 00:08:34,580
+لها سماتها الفنية والجمالية التي تجذب اهتمام الطفل
+
+86
+00:08:34,580 --> 00:08:41,840
+وتشفع رغبات الطفل إذا المعنى ذلك لابد أن نقول أن
+
+87
+00:08:41,840 --> 00:08:51,440
+اللغة قد تتجسد عبر صورة أو صوت أو لون أو رسومات أو
+
+88
+00:08:51,440 --> 00:08:58,420
+حركة أو صورة ناطقة متحركة أو صامتةإذا المعنى ذلك
+
+89
+00:08:58,420 --> 00:09:07,200
+هناك تجسيد طب لو تسألنا هنا لو تسألنا لغة
+
+90
+00:09:07,200 --> 00:09:12,460
+الأطفال لابد أن تتناسب مع مستوياتهم يعني المعنى
+
+91
+00:09:12,460 --> 00:09:17,600
+ذلك اللغة المجسدة لثقافة الطفل لابد أن تنتقل من
+
+92
+00:09:17,600 --> 00:09:23,320
+مرحلة التجريد إلى مرحلة التجسيد التجريد يعني كلام
+
+93
+00:09:23,320 --> 00:09:28,430
+مسموع التجسيد بدي أحط هذا الكلام عبر لغةعبر صورة
+
+94
+00:09:28,430 --> 00:09:33,530
+عبر صوت عبر حركة عبر رسومات بجسدليها بقربليها يعني
+
+95
+00:09:33,530 --> 00:09:39,270
+بستخدم أشياء حسية من واقع الطفل بوظفها من أجل أن
+
+96
+00:09:39,270 --> 00:09:47,490
+أعبر عن الأدب وبالتالي لو قلنا هنا الأدب الطفل
+
+97
+00:09:47,490 --> 00:09:54,910
+لابد أن يستخدم وسائل التجسيد الفني طيب لماذا لغة
+
+98
+00:09:54,910 --> 00:09:59,590
+الأدبلغة أذب الطفل الأطفال تختلف عن لغة أذب الكبار
+
+99
+00:09:59,590 --> 00:10:05,690
+هذا شيء معروف ولكن التثيير الفني في أذب الطفل ما
+
+100
+00:10:05,690 --> 00:10:11,010
+الفائدة منه؟ أول شيء أنه يتيح للعمليات العقلية
+
+101
+00:10:11,010 --> 00:10:18,290
+المعرفية أن تؤدي دورها في إثراء وإمتاع وجنة الطفل
+
+102
+00:10:21,910 --> 00:10:26,730
+لأن الطفل يكون شديد الاستجابة لعناصر التجسيد
+
+103
+00:10:26,730 --> 00:10:33,170
+اللغوية وغير لغوية يتفاعل معها، ينسجن معها الشيء
+
+104
+00:10:33,170 --> 00:10:38,830
+الثاني أن التجسيد من العوامل التي تثري عمل التخيل
+
+105
+00:10:38,830 --> 00:10:45,050
+الطفل يتخيل الصورة المركبة وهذا التجسيد الذي يغذي
+
+106
+00:10:45,050 --> 00:10:50,870
+التخيل يتيح المجال للتوسيع و التوسع في إدراك
+
+107
+00:10:50,870 --> 00:10:57,220
+المعنىإدراك الطفل للمعنى عبر التخيل يكون أكثر دقة
+
+108
+00:10:57,220 --> 00:11:04,040
+وإثراء وإشباع لرغبة الطفل الشيء الثالث أن التجسيد
+
+109
+00:11:04,040 --> 00:11:11,340
+الفني يعزز عملية الإتصال الثقافي يثري فعلية العمل
+
+110
+00:11:11,340 --> 00:11:18,960
+الأدبي وبذلك التجسيد الفني من خلاله نستطيع أن
+
+111
+00:11:18,960 --> 00:11:26,680
+نتجاوز عملية الإتصالالتقليدية اللي هي التلقين إلى
+
+112
+00:11:26,680 --> 00:11:31,900
+وسائل بعيد عن التقريرية تصبح وسائل فيه نوع من
+
+113
+00:11:31,900 --> 00:11:36,780
+أنواع الإيحاء والإفراغ كذلك التلسيذ الفن يقرب
+
+114
+00:11:36,780 --> 00:11:42,600
+المعنويات ويضعها في صور وقوالب حسية سواء كان عن
+
+115
+00:11:42,600 --> 00:11:47,860
+طريق اللون أو الصوت أو الحركة أو الصورة المتحركة
+
+116
+00:11:47,860 --> 00:11:52,050
+أو الصامتة أو أشياء أخرىإذا المعنى ذلك التسييط
+
+117
+00:11:52,050 --> 00:11:57,830
+الفني يقرب المفاهيم المعنوية المجردة ويضعها في
+
+118
+00:11:57,830 --> 00:12:04,910
+قالب حسي لكي يدركها الطفل مثلا لما نقول الطفل ما
+
+119
+00:12:04,910 --> 00:12:08,950
+المقصود بالشجاعة؟ بيعرفش أعبر عنهبس إذا نجيب له
+
+120
+00:12:08,950 --> 00:12:12,550
+رسم أو صورة متحركة تعبر عن شجاع يستطيع أن يفهمها
+
+121
+00:12:12,550 --> 00:12:16,590
+لما نقول له الطفل تعاون لا يستطيع أن يفهم ما
+
+122
+00:12:16,590 --> 00:12:20,890
+المقصود بالتعاون كمصطلح ولكن نجيب له صورة فيها
+
+123
+00:12:20,890 --> 00:12:24,810
+أطفال بتعاون مع بعضهم يستطيع أن يفهم ذلك لما نقول
+
+124
+00:12:24,810 --> 00:12:29,190
+له هو الصدق المقصود بالصدق كمفهوم مش هيعرف بس نجيب
+
+125
+00:12:29,190 --> 00:12:32,930
+له صورة تعبر عن إنسان صادق وإنسان كذاب أو إنسان
+
+126
+00:12:32,930 --> 00:12:38,180
+أمين وإنسان غير أمين عبر قصةعبر رسوم عبر صور عبر
+
+127
+00:12:38,180 --> 00:12:43,900
+مشهد كراكاتير عبر صور متحركة أشياء كثيرة لذلك هنا
+
+128
+00:12:43,900 --> 00:12:50,420
+نقول أيضا أن الكلمة في حد ذاتها فيها قوة أثرية
+
+129
+00:12:50,420 --> 00:12:55,880
+لأنها صوت و الصوت يسمعه الطفل لذلك تعتبر الكلمة
+
+130
+00:12:55,880 --> 00:13:02,820
+لبنة في سياق فنية بس تستقبل الكلمة عبر حاسس السمع
+
+131
+00:13:02,820 --> 00:13:11,930
+وتطير في ذهن الطفلماذا؟ صور كذلك أن التجسيد أو
+
+132
+00:13:11,930 --> 00:13:17,290
+اللغة المجسدة لثقافة الطفل لابد أن يصاحبها ألوان
+
+133
+00:13:17,290 --> 00:13:23,030
+وصور ورسومات وحركات لهذه الكلمات لأن الطفل يميل
+
+134
+00:13:23,030 --> 00:13:27,950
+إلى الكلمات التي يصاحبها ألوان وصور ورسوم وحركات
+
+135
+00:13:27,950 --> 00:13:34,150
+لأن هذا يثير اهتمام الطفل يثير اهتمام الطفلفالصورة
+
+136
+00:13:34,150 --> 00:13:38,850
+تنطبع في أذهان الأطفال وانطباع الصورة أو الصوت أو
+
+137
+00:13:38,850 --> 00:13:45,630
+الحركة يغذي الفهم عند الطفل ويعزز من فعالية تأثيره
+
+138
+00:13:45,630 --> 00:13:52,830
+عند الطفل لذلك الكتاب المصور يحقق التوازن بين النص
+
+139
+00:13:52,830 --> 00:13:53,450
+والصورة
+
+140
+00:13:55,950 --> 00:14:00,550
+فلذلك نجد هنا إضافة إلى الصورة يكون هنا تعليم في
+
+141
+00:14:00,550 --> 00:14:04,230
+تمتع بالصورة أو بجزء من الصورة التي تكون في داخل
+
+142
+00:14:04,230 --> 00:14:09,730
+قصة أو في داخل قصيدة فالصور الملونة في داخل القصص
+
+143
+00:14:09,730 --> 00:14:12,430
+والكتب الورقية مهمة جدا إضافة إلى ذاك الصورة
+
+144
+00:14:12,430 --> 00:14:17,410
+الملونة عبر وسائل التكنولوجيا الحديثة مهمة ومن هنا
+
+145
+00:14:17,410 --> 00:14:22,970
+الأطفال لا يستطيعون قراءة معنى الصورة بدون أي كلمة
+
+146
+00:14:22,970 --> 00:14:28,590
+فالكلمات تعزز الصورةوالصورة تعززها الكلمات لذلك
+
+147
+00:14:28,590 --> 00:14:34,570
+تعتبر هنا الحركات لون يضاف إلى جمال الصورة لون
+
+148
+00:14:34,570 --> 00:14:41,230
+يضاف إلى جمال الصورة ومن هنا نقول أن اعتماد الصورة
+
+149
+00:14:41,230 --> 00:14:47,730
+مهم جدا ولكن اكثر منها قد يحد من نموكها للطفل إذا
+
+150
+00:14:47,730 --> 00:14:51,370
+لم يكن هناك جوانب تفتح هذه الأبواب أمام الطفل لذلك
+
+151
+00:14:51,370 --> 00:14:56,730
+أدب الطفل عندما يقدم للأطفاللابد أن يقدم بلغة
+
+152
+00:14:56,730 --> 00:15:03,230
+تتناسب مع طبيعي تفكير الأطفال مع طبيعي فهم الأطفال
+
+153
+00:15:03,230 --> 00:15:08,810
+وكذلك لابد أن يعزز أدب الطفل بالتسييض الفني لأن
+
+154
+00:15:08,810 --> 00:15:13,670
+التسييض الفني يقرب المعنويات ويضعها في قالب حسي
+
+155
+00:15:13,670 --> 00:15:21,620
+يستطيع الطفل أن يفهمها لذلك نقول هنا أنأدب الطفل
+
+156
+00:15:21,620 --> 00:15:28,960
+لابد أن يعزز من توسع الخيال عند الأطفال وبالتالي
+
+157
+00:15:28,960 --> 00:15:34,900
+نقول هنا أن اللغة المجسدة لثقافة الأطفال مهم جدا
+
+158
+00:15:34,900 --> 00:15:42,520
+لأنها تقرب لهم الأشياء المجردة غير المحسوسة ترحى
+
+159
+00:15:42,520 --> 00:15:48,700
+في قلب حسين والطفل إذا وضع الأدب عبر أو تم التعبير
+
+160
+00:15:48,700 --> 00:15:54,780
+عن الأدبفي لغة تجسد المعنى لاستطاع الطفل أن يفهم
+
+161
+00:15:54,780 --> 00:16:02,060
+ذلك لذلك لا يكون هناك وسيلة واحدة من وسائل التعبير
+
+162
+00:16:02,060 --> 00:16:09,960
+عن الأدب قد يعبر بالصوت أو بالصورة أو بالرسومات أو
+
+163
+00:16:09,960 --> 00:16:16,200
+يعبر بالصورة المسموعة أو بالصورة المتحركة الحية أو
+
+164
+00:16:16,200 --> 00:16:22,920
+الصورة الصامتة لذلك ينبغيعلى من يعلم الأدب للأطفال
+
+165
+00:16:22,920 --> 00:16:29,940
+أن يختار اللغة التي تناسب الطفل لأن الأطفال ليس
+
+166
+00:16:29,940 --> 00:16:36,340
+لديهم مرحلة واحدة فقط إنما هناك مراحل ومستويات
+
+167
+00:16:36,340 --> 00:16:41,620
+لنمو الأطفال ومن هنا لابد أن نعرف احتياجات الطفل
+
+168
+00:16:41,620 --> 00:16:45,900
+ومستويات الفكر والثقافة والخيار للأطفال حتى نستطيع
+
+169
+00:16:45,900 --> 00:16:51,000
+أن نبحث عن وسائل أكثر تأثيراالوسائل التي يعبر بها
+
+170
+00:16:51,000 --> 00:16:55,420
+الأديب عن أدبه الأكثر تأثيرا في الطفل والأكثر
+
+171
+00:16:55,420 --> 00:17:02,580
+إشباعا لرغبات الأطفال فقد يتم الإختيار من شهودة في
+
+172
+00:17:02,580 --> 00:17:07,100
+مرحلة اللي هو المهن أو الطفولة المبكرة قد يختار
+
+173
+00:17:07,100 --> 00:17:14,980
+قصيدة قد يختار قصة قصيرة قد يختار sketch مسرحي قد
+
+174
+00:17:14,980 --> 00:17:20,590
+يختار هنا التمثيل وبالتالينبحث عن ما يشبع رغبة
+
+175
+00:17:20,590 --> 00:17:27,290
+الطفل وبالتالي وسائل متعددة ومتنوعة لولي المدرس
+
+176
+00:17:27,290 --> 00:17:33,510
+الذي يدرس الأطفال أو أدب الطفل أن يختار من وسائل
+
+177
+00:17:33,510 --> 00:17:40,390
+التعبير ما يعبر عن رغبة الطفل وما يشبع رغبة الطفل
+
+178
+00:17:40,390 --> 00:17:48,660
+فإذا جرب المدرس وسيلة ولم يجد هناك استجابةلابد أن
+
+179
+00:17:48,660 --> 00:17:53,660
+يغير هذه الوسيلة ولابد الوسائل أن تتطور و لا تبقى
+
+180
+00:17:53,660 --> 00:17:58,400
+جامدة حسب طبيعة النمو يعني احنا نقول وسائل أدب
+
+181
+00:17:58,400 --> 00:18:04,040
+لابد أن تلموا مع تفكير عن الطفل هذا أمر مهم جدا في
+
+182
+00:18:04,040 --> 00:18:10,560
+هذا الجانب كذلك لابد أن يرتبط أدب الطفل و لغة أدب
+
+183
+00:18:10,560 --> 00:18:15,040
+الطفل و التلسيذ الفني عن أدب الطفل ما بينالحاضر
+
+184
+00:18:15,040 --> 00:18:19,580
+والماضي والماضي والمستقبل بل أن تكون المستقبل رؤية
+
+185
+00:18:19,580 --> 00:18:25,200
+استشرفي لأطفال بمعنى أن أدب الطفل لابد أن يواكب
+
+186
+00:18:25,200 --> 00:18:31,820
+متطورات الحياة فيستخدمها وسيلة يعني الطفل الآن لو
+
+187
+00:18:31,820 --> 00:18:38,660
+جبت للطفل وخيرنا بأنه يشاهد قصة قصيرة ممثلة أو
+
+188
+00:18:38,660 --> 00:18:43,200
+مسرحية تؤدى على خشب مسرحوبين هذه القصة أن يقرأها
+
+189
+00:18:43,200 --> 00:18:48,360
+قراءة أو يسمعها سماعة سيختار التي شاهدها لأن فيها
+
+190
+00:18:48,360 --> 00:18:54,240
+صوت وفيها لون وفيها حركة هذا الأمر يأخذ بعين
+
+191
+00:18:54,240 --> 00:18:58,800
+الاعتبار في هذا الجانب ومن هنا أقول في هذه
+
+192
+00:18:58,800 --> 00:19:06,840
+المحاضرة أن الأطفال لابد أن يتم التعرف على قدراتهم
+
+193
+00:19:07,090 --> 00:19:10,990
+وعلى إمكانياتهم من هذا الجانب ان شاء الله تعالى في
+
+194
+00:19:10,990 --> 00:19:16,650
+المحاضرة القادمة سنتحدث عن أهمية أدب الأطفال وإن
+
+195
+00:19:16,650 --> 00:19:21,430
+تبقى لدينا وقت سنتحدث عن مفهوم أدب الطفل ومن هنا
+
+196
+00:19:21,430 --> 00:19:28,370
+نقول أن أدب الطفل هو عبارة عن كلام جميل وهذا
+
+197
+00:19:28,370 --> 00:19:36,610
+الكلام يحدث تأثيرا في نفوس الأطفال وهذا الكلاميعرف
+
+198
+00:19:36,610 --> 00:19:45,590
+إما شعرا أو نترا ولابد هنا أن نركز على الأدب الذي
+
+199
+00:19:45,590 --> 00:19:51,350
+يشبع احتياجات ورغبات الأطفال في هذا الجانب إذا
+
+200
+00:19:51,350 --> 00:19:58,210
+محاضرتنا اليوم كانت مركزة تحت عنوان الأدب والثقافة
+
+201
+00:19:58,210 --> 00:20:04,280
+وكذلك تحدثنا عن وسائل التسييط الفنيالمحاضرة
+
+202
+00:20:04,280 --> 00:20:07,900
+المقبلة بإذن الله سنتحدث ان شاء الله تعالى عن
+
+203
+00:20:07,900 --> 00:20:12,360
+أهمية أدب الأطفال وننتقل بعد ذلك على مفهوم أدب
+
+204
+00:20:12,360 --> 00:20:16,700
+الطفل هذا بالله و بالله التوفيق والسلام عليكم
+
+205
+00:20:16,700 --> 00:20:19,360
+ورحمة الله وبركاته
+
diff --git a/PL9fwy3NUQKwYT4Ayhm-3qTiT1ILbX-hwD/v-flFWVnvqg_raw.json b/PL9fwy3NUQKwYT4Ayhm-3qTiT1ILbX-hwD/v-flFWVnvqg_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..3eabdca5cebb1b2ebbe819853348e322f6e6741a
--- /dev/null
+++ b/PL9fwy3NUQKwYT4Ayhm-3qTiT1ILbX-hwD/v-flFWVnvqg_raw.json
@@ -0,0 +1 @@
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8592, 3555, 3615, 1975, 5016, 31371, 26108, 9307, 4032, 2288, 17082, 3555, 9307, 16247, 9566, 5172, 6027, 8978, 23758, 25724, 7649, 3555, 11933, 15730, 3714, 5016, 46958, 43500, 8315, 45595, 20498, 25961, 2655, 3714, 31747, 11622, 3660, 6055, 33753, 18871, 2407, 7649, 16247, 3215, 3555, 16070, 12984, 4587, 31845, 3660, 4032, 4117, 8848, 23275, 6055, 24401, 12984, 8315, 18871, 46952, 16373, 1211, 16712, 3794, 1829, 1829, 9566, 27188, 22653], "avg_logprob": -0.12787828759143227, "compression_ratio": 1.758974358974359, "no_speech_prob": 4.38690185546875e-05, "words": [{"start": 1176.03, "end": 1176.61, "word": "يعرف", "probability": 0.72021484375}, {"start": 1176.61, "end": 1176.97, "word": " إما", "probability": 0.81640625}, {"start": 1176.97, "end": 1177.51, "word": " شعرا", "probability": 0.95947265625}, {"start": 1177.51, "end": 1177.87, "word": " أو", "probability": 0.78271484375}, {"start": 1177.87, "end": 1178.27, "word": " نترا", "probability": 0.9449869791666666}, {"start": 1178.27, "end": 1181.05, "word": " ولابد", "probability": 0.6943766276041666}, {"start": 1181.05, "end": 1181.31, "word": " هنا", "probability": 0.97607421875}, {"start": 1181.31, "end": 1181.97, "word": " أن", "probability": 0.8994140625}, {"start": 1181.97, "end": 1182.71, "word": " نركز", "probability": 0.9744466145833334}, {"start": 1182.71, "end": 1183.59, "word": " على", "probability": 0.93994140625}, {"start": 1183.59, "end": 1185.29, "word": " الأدب", "probability": 0.9845377604166666}, {"start": 1185.29, "end": 1185.59, "word": " الذي", "probability": 0.6982421875}, {"start": 1185.59, "end": 1186.27, "word": " يشبع", "probability": 0.975830078125}, {"start": 1186.27, "end": 1187.27, "word": " احتياجات", "probability": 0.908203125}, {"start": 1187.27, "end": 1188.67, "word": " ورغبات", "probability": 0.98115234375}, {"start": 1188.67, "end": 1189.61, "word": " الأطفال", "probability": 0.9970703125}, {"start": 1189.61, "end": 1189.81, "word": " في", "probability": 0.95068359375}, {"start": 1189.81, "end": 1190.07, "word": " هذا", "probability": 0.9765625}, {"start": 1190.07, "end": 1190.59, "word": " الجانب", "probability": 0.9894205729166666}, {"start": 1190.59, "end": 1191.35, "word": " إذا", "probability": 0.616943359375}, {"start": 1191.35, "end": 1191.93, "word": " محاضرتنا", "probability": 0.86904296875}, {"start": 1191.93, "end": 1192.15, "word": " اليوم", "probability": 0.882568359375}, {"start": 1192.15, "end": 1192.53, "word": " كانت", "probability": 0.9833984375}, {"start": 1192.53, "end": 1193.53, "word": " مركزة", "probability": 0.978515625}, {"start": 1193.53, "end": 1195.23, "word": " تحت", "probability": 0.677978515625}, {"start": 1195.23, "end": 1196.29, "word": " عنوان", "probability": 0.9680989583333334}, {"start": 1196.29, "end": 1197.49, "word": " الأدب", "probability": 0.9651692708333334}, {"start": 1197.49, "end": 1198.21, "word": " والثقافة", "probability": 0.95185546875}, {"start": 1198.21, "end": 1199.21, "word": " وكذلك", "probability": 0.925537109375}, {"start": 1199.21, "end": 1199.99, "word": " تحدثنا", "probability": 0.88720703125}, {"start": 1199.99, "end": 1200.65, "word": " عن", "probability": 0.99267578125}, {"start": 1200.65, "end": 1201.21, "word": " وسائل", "probability": 0.9825846354166666}, {"start": 1201.21, "end": 1202.01, "word": " التسييط", "probability": 0.70634765625}, {"start": 1202.01, "end": 1202.57, "word": " الفني", "probability": 0.77587890625}], "temperature": 1.0}, {"id": 44, "seek": 121935, "start": 1203.66, "end": 1219.36, "text": "المحاضرة المقبلة بإذن الله سنتحدث ان شاء الله تعالى عن أهمية أدب الأطفال وننتقل بعد ذلك على مفهوم أدب الطفل هذا بالله و بالله التوفيق والسلام عليكم ورحمة الله وبركاته", "tokens": [45340, 5016, 46958, 25720, 9673, 4587, 36150, 3660, 4724, 28814, 8848, 1863, 21984, 8608, 29399, 24401, 12984, 16472, 13412, 16606, 21984, 37279, 6027, 7578, 18871, 5551, 16095, 10632, 5551, 3215, 3555, 16247, 9566, 5172, 6027, 4032, 1863, 29399, 4587, 1211, 39182, 29910, 23275, 15844, 3714, 5172, 3224, 20498, 5551, 3215, 3555, 41950, 5172, 1211, 23758, 20666, 43761, 4032, 20666, 43761, 16712, 38688, 1829, 4587, 16070, 3794, 37440, 25894, 24793, 4032, 2288, 35571, 3660, 21984, 4032, 26890, 4117, 9307, 3224], "avg_logprob": -0.0877929656766355, "compression_ratio": 1.7823529411764707, "no_speech_prob": 4.601478576660156e-05, "words": [{"start": 1203.66, "end": 1204.28, "word": "المحاضرة", "probability": 0.9755859375}, {"start": 1204.28, "end": 1204.72, "word": " المقبلة", "probability": 0.9866943359375}, {"start": 1204.72, "end": 1205.0, "word": " بإذن", "probability": 0.83721923828125}, {"start": 1205.0, "end": 1205.2, "word": " الله", "probability": 0.9521484375}, {"start": 1205.2, "end": 1206.4, "word": " سنتحدث", "probability": 0.970703125}, {"start": 1206.4, "end": 1206.7, "word": " ان", "probability": 0.46044921875}, {"start": 1206.7, "end": 1206.92, "word": " شاء", "probability": 0.96533203125}, {"start": 1206.92, "end": 1206.98, "word": " الله", "probability": 0.9443359375}, {"start": 1206.98, "end": 1207.42, "word": " تعالى", "probability": 0.9288736979166666}, {"start": 1207.42, "end": 1207.9, "word": " عن", "probability": 0.97705078125}, {"start": 1207.9, "end": 1208.66, "word": " أهمية", "probability": 0.9422200520833334}, {"start": 1208.66, "end": 1209.4, "word": " أدب", "probability": 0.9833984375}, {"start": 1209.4, "end": 1210.1, "word": " الأطفال", "probability": 0.998291015625}, {"start": 1210.1, "end": 1211.02, "word": " وننتقل", "probability": 0.89990234375}, {"start": 1211.02, "end": 1211.24, "word": " بعد", "probability": 0.93994140625}, {"start": 1211.24, "end": 1211.5, "word": " ذلك", "probability": 0.99609375}, {"start": 1211.5, "end": 1211.62, "word": " على", "probability": 0.765625}, {"start": 1211.62, "end": 1212.04, "word": " مفهوم", "probability": 0.930419921875}, {"start": 1212.04, "end": 1212.36, "word": " أدب", "probability": 0.98876953125}, {"start": 1212.36, "end": 1212.86, "word": " الطفل", "probability": 0.9951171875}, {"start": 1212.86, "end": 1213.96, "word": " هذا", "probability": 0.7607421875}, {"start": 1213.96, "end": 1214.32, "word": " بالله", "probability": 0.6767578125}, {"start": 1214.32, "end": 1214.52, "word": " و", "probability": 0.640625}, {"start": 1214.52, "end": 1214.78, "word": " بالله", "probability": 0.826904296875}, {"start": 1214.78, "end": 1215.4, "word": " التوفيق", "probability": 0.991455078125}, {"start": 1215.4, "end": 1216.1, "word": " والسلام", "probability": 0.8567708333333334}, {"start": 1216.1, "end": 1216.7, "word": " عليكم", "probability": 0.963134765625}, {"start": 1216.7, "end": 1217.58, "word": " ورحمة", "probability": 0.958740234375}, {"start": 1217.58, "end": 1217.96, "word": " الله", "probability": 0.96923828125}, {"start": 1217.96, "end": 1219.36, "word": " وبركاته", "probability": 0.97509765625}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 1222.2984375, "duration_after_vad": 1191.991874999999}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwYT4Ayhm-3qTiT1ILbX-hwD/v-flFWVnvqg_raw.srt b/PL9fwy3NUQKwYT4Ayhm-3qTiT1ILbX-hwD/v-flFWVnvqg_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..c9e1377eb4cd9579efc16583fbfead01a3302278
--- /dev/null
+++ b/PL9fwy3NUQKwYT4Ayhm-3qTiT1ILbX-hwD/v-flFWVnvqg_raw.srt
@@ -0,0 +1,820 @@
+1
+00:00:01,450 --> 00:00:05,930
+بسم الله الرحمن الرحيم بداية نرحب بطلاب وطالبات
+
+2
+00:00:05,930 --> 00:00:10,890
+مساق أدب الطفل ونسأل الله سبحانه وتعالى السلام
+
+3
+00:00:10,890 --> 00:00:17,010
+والتوفيق للجميع المساق اللذي بين أيدينا في هذه ..
+
+4
+00:00:17,010 --> 00:00:25,010
+في هذا الفصل مساق أدب الطفل لابد بداية أن نتعرف
+
+5
+00:00:25,010 --> 00:00:32,540
+على مفهوم الأدب مفهوم الثقافة لأن في الكتابأول
+
+6
+00:00:32,540 --> 00:00:36,500
+عنوان في الفصل الأول أدب والثقافة فده بده أن نشرح
+
+7
+00:00:36,500 --> 00:00:40,120
+ما المقصود بالأدب وما المقصود بالثقافة وطبيعة
+
+8
+00:00:40,120 --> 00:00:43,780
+العلاقات التي تربط الثقافة بالأدب بداية نقول أن
+
+9
+00:00:43,780 --> 00:00:50,120
+المفهوم السائد قديما لمفردة الأدب كان مفهوما حسيا
+
+10
+00:00:50,120 --> 00:00:55,800
+ماديا يقصد به دعوة إلى الطعام لا أريد التوسع في
+
+11
+00:00:55,800 --> 00:01:02,970
+هذا الجانب ثم بعد ذلك التظورةهذا المفهوم فأصبح
+
+12
+00:01:02,970 --> 00:01:08,350
+يُقصد به أو أخذ بعد أخلاقيا لذلك قال النبي صلى
+
+13
+00:01:08,350 --> 00:01:16,370
+الله عليه وسلم أدبني ربي فأحسن تأديبي ثم
+
+14
+00:01:16,370 --> 00:01:22,530
+بعد ذلك انتقل و تطور هذا المفهوموأصبح يقصد به كلام
+
+15
+00:01:22,530 --> 00:01:28,630
+الجميل المؤثر الذي يعبر فيه الأذيب عن أحاسيسه وعن
+
+16
+00:01:28,630 --> 00:01:34,290
+انفعالاته وعن عواطفه وعن أفكاره ويحدث هذا الكلام
+
+17
+00:01:34,290 --> 00:01:40,610
+الجميل أثرا ومتعة في نفوس السمعين سواء كان هذا
+
+18
+00:01:40,610 --> 00:01:49,130
+الكلام شعرا أم نترا وبالتالي لو قلنا الأدب الطفل
+
+19
+00:01:49,970 --> 00:01:54,130
+منهم من عرفوا هذا الأدب أنه الكلام الجميل الذي
+
+20
+00:01:54,130 --> 00:02:01,590
+يحدث تأثيرا في نفس الأطفال ويحدث متعة فنية وهذا
+
+21
+00:02:01,590 --> 00:02:08,350
+الكلام سواء كان شعرا او نثرا هو المادة الأساسية
+
+22
+00:02:08,350 --> 00:02:14,970
+للأدب وصناعة وشكيل الأدب هي اللغة فلابد لمن يكتب
+
+23
+00:02:14,970 --> 00:02:21,930
+الأدب أن يمتلك اللغةولكن السؤال هل لكل من يسمع
+
+24
+00:02:21,930 --> 00:02:25,710
+الأدب أن يمتلكوا اللغة نقول يفضل الكبار يمتلكون
+
+25
+00:02:25,710 --> 00:02:30,650
+اللغة ولكن الصغار في مراحة المهد وربما يمتد إلى
+
+26
+00:02:30,650 --> 00:02:35,050
+مراحة الطفولة المبكرة لا يمتلكون اللغة وبالتالي
+
+27
+00:02:35,050 --> 00:02:41,170
+يحدث هناك وسائل تعبيرية أخرى كالصورة أو الموسيقى
+
+28
+00:02:41,170 --> 00:02:46,530
+أو نتحدث عنفيما يتعلق بالصورة الصامت أو المتحركة
+
+29
+00:02:46,530 --> 00:02:52,010
+أو فيما يتعلق بالتجسيد الألفاظ عبر قوالب حسية
+
+30
+00:02:52,010 --> 00:02:57,270
+يستطيع الطفل أن يفهمها و هذه قوالب مستقاة من بيئة
+
+31
+00:02:57,270 --> 00:03:01,050
+الطفل إذا المعنى ذات مفهوم الأدب لابد أن نعرف أن
+
+32
+00:03:01,050 --> 00:03:05,910
+الأدب و لغة الأدب تختلف عن اللغة التداولية بين
+
+33
+00:03:05,910 --> 00:03:11,370
+الناس وجه الاختلاف يقمن في أن الأدب يحمل في داخله
+
+34
+00:03:11,370 --> 00:03:19,360
+قيمفنية وجمالية تحدث تأثيرا في وجهها المتلقي إضافة
+
+35
+00:03:19,360 --> 00:03:23,000
+إلى ذلك أن الأدب لا يتعامل مع الأشياء تعاملا
+
+36
+00:03:23,000 --> 00:03:33,860
+مباشرا وإنما تعاملا مجازيا إيحائيا رمزيا الثقافة
+
+37
+00:03:33,860 --> 00:03:41,840
+إذا ما عدنا إلى مفهوم الثقافة عرفها Edward Taylor
+
+38
+00:03:42,530 --> 00:03:47,590
+في داخل كتاب في كتابه الثقافة البدائية قال أن
+
+39
+00:03:47,590 --> 00:03:52,010
+الثقافة عبارة عن ماذا؟ قال عبارة عن مُركّب وهذا
+
+40
+00:03:52,010 --> 00:03:56,250
+المُركّب يجتمل على ماذا؟ قال يجتمل على المعرفة
+
+41
+00:03:56,250 --> 00:04:02,910
+والعقائل والفن والأخلاق والقانون والعداد والقدرات
+
+42
+00:04:02,910 --> 00:04:10,530
+التي يكتسبها الإنسان يكتسبها الإنسان بوصفه داخل
+
+43
+00:04:10,530 --> 00:04:17,720
+مجتمعبوصفه عضوًا داخل المجتمع وبالتالي الثقافة
+
+44
+00:04:17,720 --> 00:04:26,980
+ليست واحدة تتبين حسب تباين واختلاف المجتمعات طب
+
+45
+00:04:26,980 --> 00:04:31,680
+يقولنا هنا أقسام الثقافة منهم ان قسم الثقافة إلى
+
+46
+00:04:31,680 --> 00:04:36,500
+ثلاث أقسام عموميات هذا قسم الأول القسم الثاني
+
+47
+00:04:36,500 --> 00:04:43,160
+الخصوصيات القسم الثالث البديلاتما المقصود بالقسم
+
+48
+00:04:43,160 --> 00:04:46,940
+الأول العمليات يعني هذا عمليات من عنوانه أنه عام
+
+49
+00:04:46,940 --> 00:04:55,500
+يشترك بينها مجتمعات متعددة بمعنى أن أنماط السلوك
+
+50
+00:04:55,500 --> 00:05:00,520
+والجوانب الحتمية كل لغة الأسرة موجودة في كل مجتمع
+
+51
+00:05:00,520 --> 00:05:10,850
+الخصيات ما يتميز به مجتمع أو قطاعفي داخل المجتمع
+
+52
+00:05:10,850 --> 00:05:17,930
+عن مجتمع او قطاع اخر زي ما احنا في هناك اختلاف
+
+53
+00:05:17,930 --> 00:05:26,030
+وخصية لكل لهجة في بيئة معينة وبالتالي المقصود
+
+54
+00:05:26,030 --> 00:05:30,250
+بالخصيات ان ما يتميز به قطاع معين من قطاعات
+
+55
+00:05:30,250 --> 00:05:37,900
+المجتمع من تميز ثقافي او فكريوالمقصود بالنوع
+
+56
+00:05:37,900 --> 00:05:45,000
+الثالث القسم الثالث البديلات أي أن هناك ثقافة
+
+57
+00:05:45,000 --> 00:05:53,120
+تتسلل إلى المجتمع عبر الاحتكاك مع ثقافات أخرى عبر
+
+58
+00:05:53,120 --> 00:05:56,680
+الاحتكاك وبالتالي بديلات يعني هناك ثقافة بديلة
+
+59
+00:05:56,680 --> 00:06:02,820
+وأكبر ذليل على ذلك عندما يتابع الطفل الثقافة
+
+60
+00:06:02,820 --> 00:06:09,330
+الغربية غير المحليةعبر شاشات التلفاز أو عبر أجهزة
+
+61
+00:06:09,330 --> 00:06:13,850
+الحسوب أو عبر ربما الأشياء المقبوعة أو المرسومة
+
+62
+00:06:13,850 --> 00:06:17,190
+الأشياء
+
+63
+00:06:17,190 --> 00:06:25,490
+المقبوعة أو المرسومة هناك نقطة أخرى ثقافة الأطفال
+
+64
+00:06:25,490 --> 00:06:30,290
+ثقافة نوعية متصلة مع ثقافة المجتمع وليس منفصلة
+
+65
+00:06:30,290 --> 00:06:37,460
+عنها فهي جزء لا يتجزأ من ثقافة المجتمعوتشترك احنا
+
+66
+00:06:37,460 --> 00:06:42,940
+قلنا هناك خصية لثقافة الطفل وهي متصلة مع ثقافة
+
+67
+00:06:42,940 --> 00:06:47,860
+المجتمع أي مع ثقافة الكبار ولكنها ليست منفصلة عنها
+
+68
+00:06:47,860 --> 00:06:55,000
+ومن هنا نجد أن ثقافة الأطفال تنفرد بخصائص تتميز
+
+69
+00:06:55,000 --> 00:07:01,220
+وتختلف فيها عن ثقافة الكبار لذلك نجد في ثقافة
+
+70
+00:07:01,220 --> 00:07:05,380
+الصغار معايير غير موجودة في ثقافة الكبار كاللعب
+
+71
+00:07:07,040 --> 00:07:15,140
+كذلك الرسومات كذلك أشكال العروض المختلفة لذلك نجد
+
+72
+00:07:15,140 --> 00:07:19,560
+أيضًا في داخل ثقافات الأطفال تباين لأن الأطفال
+
+73
+00:07:19,560 --> 00:07:24,640
+ليسوا على مستوى واحد من الفكر والثقافة إنما هناك
+
+74
+00:07:24,640 --> 00:07:31,960
+ثقافات متباينة لذلك عندما نقول أن ثقات الطفل
+
+75
+00:07:31,960 --> 00:07:34,860
+أساسية
+
+76
+00:07:35,220 --> 00:07:40,700
+ولكن ينبغي أن تكون من داخل المجتمع طب نقول هنا
+
+77
+00:07:40,700 --> 00:07:47,020
+الأدب والثقافة طبيعة العلاقة بينهما سنقول أن هناك
+
+78
+00:07:47,020 --> 00:07:51,620
+علاقة وطيدة بين الثقافة والأدب فالأدب يعبر عن
+
+79
+00:07:51,620 --> 00:07:57,400
+ثقافة المجتمع الأدب يعبر عن ثقافة الأفراد
+
+80
+00:07:57,400 --> 00:08:03,060
+والجماعات الأدب وسيلة من وسائل التعبير عن الثقافة
+
+81
+00:08:03,420 --> 00:08:08,740
+ولكن ليس هو الوسيلة الوحيدة التاريخ يعبر عن
+
+82
+00:08:08,740 --> 00:08:14,280
+الثقافة الأدب يعبر عن الثقافة الاجتماعيات يعبر عن
+
+83
+00:08:14,280 --> 00:08:17,580
+الثقافة الفلسفة علم النفس يعبر عن ثقافة المجتمع
+
+84
+00:08:17,580 --> 00:08:27,780
+ومن هنا أقول أن الثقافة تجسد عبر اللغة ولغة الأدب
+
+85
+00:08:29,200 --> 00:08:34,580
+لها سماتها الفنية والجمالية التي تجذب اهتمام الطفل
+
+86
+00:08:34,580 --> 00:08:41,840
+وتشفع رغبات الطفل إذا المعنى ذلك لابد أن نقول أن
+
+87
+00:08:41,840 --> 00:08:51,440
+اللغة قد تتجسد عبر صورة أو صوت أو لون أو رسومات أو
+
+88
+00:08:51,440 --> 00:08:58,420
+حركة أو صورة ناطقة متحركة أو صامتةإذا المعنى ذلك
+
+89
+00:08:58,420 --> 00:09:07,200
+هناك تجسيد طب لو تسألنا هنا لو تسألنا لغة
+
+90
+00:09:07,200 --> 00:09:12,460
+الأطفال لابد أن تتناسب مع مستوياتهم يعني المعنى
+
+91
+00:09:12,460 --> 00:09:17,600
+ذلك اللغة المجسدة لثقافة الطفل لابد أن تنتقل من
+
+92
+00:09:17,600 --> 00:09:23,320
+مرحلة التجريد إلى مرحلة التجسيد التجريد يعني كلام
+
+93
+00:09:23,320 --> 00:09:28,430
+مسموع التجسيد بدي أحط هذا الكلام عبر لغةعبر صورة
+
+94
+00:09:28,430 --> 00:09:33,530
+عبر صوت عبر حركة عبر رسومات بجسدليها بقربليها يعني
+
+95
+00:09:33,530 --> 00:09:39,270
+بستخدم أشياء حسية من واقع الطفل بوظفها من أجل أن
+
+96
+00:09:39,270 --> 00:09:47,490
+أعبر عن الأدب وبالتالي لو قلنا هنا الأدب الطفل
+
+97
+00:09:47,490 --> 00:09:54,910
+لابد أن يستخدم وسائل التجسيد الفني طيب لماذا لغة
+
+98
+00:09:54,910 --> 00:09:59,590
+الأدبلغة أذب الطفل الأطفال تختلف عن لغة أذب الكبار
+
+99
+00:09:59,590 --> 00:10:05,690
+هذا شيء معروف ولكن التثيير الفني في أذب الطفل ما
+
+100
+00:10:05,690 --> 00:10:11,010
+الفائدة منه؟ أول شيء أنه يتيح للعمليات العقلية
+
+101
+00:10:11,010 --> 00:10:18,290
+المعرفية أن تؤدي دورها في إثراء وإمتاع وجنة الطفل
+
+102
+00:10:21,910 --> 00:10:26,730
+لأن الطفل يكون شديد الاستجابة لعناصر التجسيد
+
+103
+00:10:26,730 --> 00:10:33,170
+اللغوية وغير لغوية يتفاعل معها، ينسجن معها الشيء
+
+104
+00:10:33,170 --> 00:10:38,830
+الثاني أن التجسيد من العوامل التي تثري عمل التخيل
+
+105
+00:10:38,830 --> 00:10:45,050
+الطفل يتخيل الصورة المركبة وهذا التجسيد الذي يغذي
+
+106
+00:10:45,050 --> 00:10:50,870
+التخيل يتيح المجال للتوسيع و التوسع في إدراك
+
+107
+00:10:50,870 --> 00:10:57,220
+المعنىإدراك الطفل للمعنى عبر التخيل يكون أكثر دقة
+
+108
+00:10:57,220 --> 00:11:04,040
+وإثراء وإشباع لرغبة الطفل الشيء الثالث أن التجسيد
+
+109
+00:11:04,040 --> 00:11:11,340
+الفني يعزز عملية الإتصال الثقافي يثري فعلية العمل
+
+110
+00:11:11,340 --> 00:11:18,960
+الأدبي وبذلك التجسيد الفني من خلاله نستطيع أن
+
+111
+00:11:18,960 --> 00:11:26,680
+نتجاوز عملية الإتصالالتقليدية اللي هي التلقين إلى
+
+112
+00:11:26,680 --> 00:11:31,900
+وسائل بعيد عن التقريرية تصبح وسائل فيه نوع من
+
+113
+00:11:31,900 --> 00:11:36,780
+أنواع الإيحاء والإفراغ كذلك التلسيذ الفن يقرب
+
+114
+00:11:36,780 --> 00:11:42,600
+المعنويات ويضعها في صور وقوالب حسية سواء كان عن
+
+115
+00:11:42,600 --> 00:11:47,860
+طريق اللون أو الصوت أو الحركة أو الصورة المتحركة
+
+116
+00:11:47,860 --> 00:11:52,050
+أو الصامتة أو أشياء أخرىإذا المعنى ذلك التسييط
+
+117
+00:11:52,050 --> 00:11:57,830
+الفني يقرب المفاهيم المعنوية المجردة ويضعها في
+
+118
+00:11:57,830 --> 00:12:04,910
+قالب حسي لكي يدركها الطفل مثلا لما نقول الطفل ما
+
+119
+00:12:04,910 --> 00:12:08,950
+المقصود بالشجاعة؟ بيعرفش أعبر عنهبس إذا نجيب له
+
+120
+00:12:08,950 --> 00:12:12,550
+رسم أو صورة متحركة تعبر عن شجاع يستطيع أن يفهمها
+
+121
+00:12:12,550 --> 00:12:16,590
+لما نقول له الطفل تعاون لا يستطيع أن يفهم ما
+
+122
+00:12:16,590 --> 00:12:20,890
+المقصود بالتعاون كمصطلح ولكن نجيب له صورة فيها
+
+123
+00:12:20,890 --> 00:12:24,810
+أطفال بتعاون مع بعضهم يستطيع أن يفهم ذلك لما نقول
+
+124
+00:12:24,810 --> 00:12:29,190
+له هو الصدق المقصود بالصدق كمفهوم مش هيعرف بس نجيب
+
+125
+00:12:29,190 --> 00:12:32,930
+له صورة تعبر عن إنسان صادق وإنسان كذاب أو إنسان
+
+126
+00:12:32,930 --> 00:12:38,180
+أمين وإنسان غير أمين عبر قصةعبر رسوم عبر صور عبر
+
+127
+00:12:38,180 --> 00:12:43,900
+مشهد كراكاتير عبر صور متحركة أشياء كثيرة لذلك هنا
+
+128
+00:12:43,900 --> 00:12:50,420
+نقول أيضا أن الكلمة في حد ذاتها فيها قوة أثرية
+
+129
+00:12:50,420 --> 00:12:55,880
+لأنها صوت و الصوت يسمعه الطفل لذلك تعتبر الكلمة
+
+130
+00:12:55,880 --> 00:13:02,820
+لبنة في سياق فنية بس تستقبل الكلمة عبر حاسس السمع
+
+131
+00:13:02,820 --> 00:13:11,930
+وتطير في ذهن الطفلماذا؟ صور كذلك أن التجسيد أو
+
+132
+00:13:11,930 --> 00:13:17,290
+اللغة المجسدة لثقافة الطفل لابد أن يصاحبها ألوان
+
+133
+00:13:17,290 --> 00:13:23,030
+وصور ورسومات وحركات لهذه الكلمات لأن الطفل يميل
+
+134
+00:13:23,030 --> 00:13:27,950
+إلى الكلمات التي يصاحبها ألوان وصور ورسوم وحركات
+
+135
+00:13:27,950 --> 00:13:34,150
+لأن هذا يثير اهتمام الطفل يثير اهتمام الطفلفالصورة
+
+136
+00:13:34,150 --> 00:13:38,850
+تنطبع في أذهان الأطفال وانطباع الصورة أو الصوت أو
+
+137
+00:13:38,850 --> 00:13:45,630
+الحركة يغذي الفهم عند الطفل ويعزز من فعالية تأثيره
+
+138
+00:13:45,630 --> 00:13:52,830
+عند الطفل لذلك الكتاب المصور يحقق التوازن بين النص
+
+139
+00:13:52,830 --> 00:13:53,450
+والصورة
+
+140
+00:13:55,950 --> 00:14:00,550
+فلذلك نجد هنا إضافة إلى الصورة يكون هنا تعليم في
+
+141
+00:14:00,550 --> 00:14:04,230
+تمتع بالصورة أو بجزء من الصورة التي تكون في داخل
+
+142
+00:14:04,230 --> 00:14:09,730
+قصة أو في داخل قصيدة فالصور الملونة في داخل القصص
+
+143
+00:14:09,730 --> 00:14:12,430
+والكتب الورقية مهمة جدا إضافة إلى ذاك الصورة
+
+144
+00:14:12,430 --> 00:14:17,410
+الملونة عبر وسائل التكنولوجيا الحديثة مهمة ومن هنا
+
+145
+00:14:17,410 --> 00:14:22,970
+الأطفال لا يستطيعون قراءة معنى الصورة بدون أي كلمة
+
+146
+00:14:22,970 --> 00:14:28,590
+فالكلمات تعزز الصورةوالصورة تعززها الكلمات لذلك
+
+147
+00:14:28,590 --> 00:14:34,570
+تعتبر هنا الحركات لون يضاف إلى جمال الصورة لون
+
+148
+00:14:34,570 --> 00:14:41,230
+يضاف إلى جمال الصورة ومن هنا نقول أن اعتماد الصورة
+
+149
+00:14:41,230 --> 00:14:47,730
+مهم جدا ولكن اكثر منها قد يحد من نموكها للطفل إذا
+
+150
+00:14:47,730 --> 00:14:51,370
+لم يكن هناك جوانب تفتح هذه الأبواب أمام الطفل لذلك
+
+151
+00:14:51,370 --> 00:14:56,730
+أدب الطفل عندما يقدم للأطفاللابد أن يقدم بلغة
+
+152
+00:14:56,730 --> 00:15:03,230
+تتناسب مع طبيعي تفكير الأطفال مع طبيعي فهم الأطفال
+
+153
+00:15:03,230 --> 00:15:08,810
+وكذلك لابد أن يعزز أدب الطفل بالتسييض الفني لأن
+
+154
+00:15:08,810 --> 00:15:13,670
+التسييض الفني يقرب المعنويات ويضعها في قالب حسي
+
+155
+00:15:13,670 --> 00:15:21,620
+يستطيع الطفل أن يفهمها لذلك نقول هنا أنأدب الطفل
+
+156
+00:15:21,620 --> 00:15:28,960
+لابد أن يعزز من توسع الخيال عند الأطفال وبالتالي
+
+157
+00:15:28,960 --> 00:15:34,900
+نقول هنا أن اللغة المجسدة لثقافة الأطفال مهم جدا
+
+158
+00:15:34,900 --> 00:15:42,520
+لأنها تقرب لهم الأشياء المجردة غير المحسوسة ترحى
+
+159
+00:15:42,520 --> 00:15:48,700
+في قلب حسين والطفل إذا وضع الأدب عبر أو تم التعبير
+
+160
+00:15:48,700 --> 00:15:54,780
+عن الأدبفي لغة تجسد المعنى لاستطاع الطفل أن يفهم
+
+161
+00:15:54,780 --> 00:16:02,060
+ذلك لذلك لا يكون هناك وسيلة واحدة من وسائل التعبير
+
+162
+00:16:02,060 --> 00:16:09,960
+عن الأدب قد يعبر بالصوت أو بالصورة أو بالرسومات أو
+
+163
+00:16:09,960 --> 00:16:16,200
+يعبر بالصورة المسموعة أو بالصورة المتحركة الحية أو
+
+164
+00:16:16,200 --> 00:16:22,920
+الصورة الصامتة لذلك ينبغيعلى من يعلم الأدب للأطفال
+
+165
+00:16:22,920 --> 00:16:29,940
+أن يختار اللغة التي تناسب الطفل لأن الأطفال ليس
+
+166
+00:16:29,940 --> 00:16:36,340
+لديهم مرحلة واحدة فقط إنما هناك مراحل ومستويات
+
+167
+00:16:36,340 --> 00:16:41,620
+لنمو الأطفال ومن هنا لابد أن نعرف احتياجات الطفل
+
+168
+00:16:41,620 --> 00:16:45,900
+ومستويات الفكر والثقافة والخيار للأطفال حتى نستطيع
+
+169
+00:16:45,900 --> 00:16:51,000
+أن نبحث عن وسائل أكثر تأثيراالوسائل التي يعبر بها
+
+170
+00:16:51,000 --> 00:16:55,420
+الأديب عن أدبه الأكثر تأثيرا في الطفل والأكثر
+
+171
+00:16:55,420 --> 00:17:02,580
+إشباعا لرغبات الأطفال فقد يتم الإختيار من شهودة في
+
+172
+00:17:02,580 --> 00:17:07,100
+مرحلة اللي هو المهن أو الطفولة المبكرة قد يختار
+
+173
+00:17:07,100 --> 00:17:14,980
+قصيدة قد يختار قصة قصيرة قد يختار sketch مسرحي قد
+
+174
+00:17:14,980 --> 00:17:20,590
+يختار هنا التمثيل وبالتالينبحث عن ما يشبع رغبة
+
+175
+00:17:20,590 --> 00:17:27,290
+الطفل وبالتالي وسائل متعددة ومتنوعة لولي المدرس
+
+176
+00:17:27,290 --> 00:17:33,510
+الذي يدرس الأطفال أو أدب الطفل أن يختار من وسائل
+
+177
+00:17:33,510 --> 00:17:40,390
+التعبير ما يعبر عن رغبة الطفل وما يشبع رغبة الطفل
+
+178
+00:17:40,390 --> 00:17:48,660
+فإذا جرب المدرس وسيلة ولم يجد هناك استجابةلابد أن
+
+179
+00:17:48,660 --> 00:17:53,660
+يغير هذه الوسيلة ولابد الوسائل أن تتطور و لا تبقى
+
+180
+00:17:53,660 --> 00:17:58,400
+جامدة حسب طبيعة النمو يعني احنا نقول وسائل أدب
+
+181
+00:17:58,400 --> 00:18:04,040
+لابد أن تلموا مع تفكير عن الطفل هذا أمر مهم جدا في
+
+182
+00:18:04,040 --> 00:18:10,560
+هذا الجانب كذلك لابد أن يرتبط أدب الطفل و لغة أدب
+
+183
+00:18:10,560 --> 00:18:15,040
+الطفل و التلسيذ الفني عن أدب الطفل ما بينالحاضر
+
+184
+00:18:15,040 --> 00:18:19,580
+والماضي والماضي والمستقبل بل أن تكون المستقبل رؤية
+
+185
+00:18:19,580 --> 00:18:25,200
+استشرفي لأطفال بمعنى أن أدب الطفل لابد أن يواكب
+
+186
+00:18:25,200 --> 00:18:31,820
+متطورات الحياة فيستخدمها وسيلة يعني الطفل الآن لو
+
+187
+00:18:31,820 --> 00:18:38,660
+جبت للطفل وخيرنا بأنه يشاهد قصة قصيرة ممثلة أو
+
+188
+00:18:38,660 --> 00:18:43,200
+مسرحية تؤدى على خشب مسرحوبين هذه القصة أن يقرأها
+
+189
+00:18:43,200 --> 00:18:48,360
+قراءة أو يسمعها سماعة سيختار التي شاهدها لأن فيها
+
+190
+00:18:48,360 --> 00:18:54,240
+صوت وفيها لون وفيها حركة هذا الأمر يأخذ بعين
+
+191
+00:18:54,240 --> 00:18:58,800
+الاعتبار في هذا الجانب ومن هنا أقول في هذه
+
+192
+00:18:58,800 --> 00:19:06,840
+المحاضرة أن الأطفال لابد أن يتم التعرف على قدراتهم
+
+193
+00:19:07,090 --> 00:19:10,990
+وعلى إمكانياتهم من هذا الجانب ان شاء الله تعالى في
+
+194
+00:19:10,990 --> 00:19:16,650
+المحاضرة القادمة سنتحدث عن أهمية أدب الأطفال وإن
+
+195
+00:19:16,650 --> 00:19:21,430
+تبقى لدينا وقت سنتحدث عن مفهوم أدب الطفل ومن هنا
+
+196
+00:19:21,430 --> 00:19:28,370
+نقول أن أدب الطفل هو عبارة عن كلام جميل وهذا
+
+197
+00:19:28,370 --> 00:19:36,610
+الكلام يحدث تأثيرا في نفوس الأطفال وهذا الكلاميعرف
+
+198
+00:19:36,610 --> 00:19:45,590
+إما شعرا أو نترا ولابد هنا أن نركز على الأدب الذي
+
+199
+00:19:45,590 --> 00:19:51,350
+يشبع احتياجات ورغبات الأطفال في هذا الجانب إذا
+
+200
+00:19:51,350 --> 00:19:58,210
+محاضرتنا اليوم كانت مركزة تحت عنوان الأدب والثقافة
+
+201
+00:19:58,210 --> 00:20:04,280
+وكذلك تحدثنا عن وسائل التسييط الفنيالمحاضرة
+
+202
+00:20:04,280 --> 00:20:07,900
+المقبلة بإذن الله سنتحدث ان شاء الله تعالى عن
+
+203
+00:20:07,900 --> 00:20:12,360
+أهمية أدب الأطفال وننتقل بعد ذلك على مفهوم أدب
+
+204
+00:20:12,360 --> 00:20:16,700
+الطفل هذا بالله و بالله التوفيق والسلام عليكم
+
+205
+00:20:16,700 --> 00:20:19,360
+ورحمة الله وبركاته
+
diff --git a/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/0H-DC7bobLw.srt b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/0H-DC7bobLw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..f32f2f87586a5c9086d22aeb07dacba8135113f1
--- /dev/null
+++ b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/0H-DC7bobLw.srt
@@ -0,0 +1,2274 @@
+1
+00:00:01,500 --> 00:00:06,520
+بسم الله الرحمن الرحيم، نستكمل مع محاضرة الـ
+
+2
+00:00:06,520 --> 00:00:11,720
+diabetes mellitus clinical utility of measuring
+
+3
+00:00:11,720 --> 00:00:15,600
+insulin, proinsulin, C-peptide and glucagon، يبقى
+
+4
+00:00:15,600 --> 00:00:22,780
+إيش الهدف، إيش الفائدة من قياس هذه الـanalytes
+
+5
+00:00:22,780 --> 00:00:28,450
+المختلفة؟ طبعا بداية يعني احنا ممكن نتم القياس حسب
+
+6
+00:00:28,450 --> 00:00:38,050
+زي ما هنشوف الأسباب المختلفة لكن يعني ما فيش role
+
+7
+00:00:38,050 --> 00:00:43,320
+أو ما فيش فائدة من الـroutine testing، يعني احنا ممكن
+
+8
+00:00:43,320 --> 00:00:48,700
+نقيس و انشخص على سبيل المثال نعمل differential
+
+9
+00:00:48,700 --> 00:00:53,640
+diagnosis بين لو type 1 و type 2. طيب الآن هل يعني
+
+10
+00:00:53,640 --> 00:00:57,700
+نستمر بشكل روتيني بقياس مثلاً الـinsulin أو قياس
+
+11
+00:00:57,700 --> 00:01:01,800
+الـC-peptide؟ لأ، لا يوجد فائدة. يبقى ليه الهدف
+
+12
+00:01:01,800 --> 00:01:05,900
+المرجع و بعد هيك يعني لا يوجد داعي ليه الـroutine
+
+13
+00:01:05,900 --> 00:01:14,420
+testing بما تعلق بالإنسولين. عنا الأهداف لقياس
+
+14
+00:01:14,420 --> 00:01:19,860
+الإنسولين: Evaluation of fasting hypoglycemia، عشان
+
+15
+00:01:19,860 --> 00:01:23,740
+نشوف إيش سبب اللي هو النقص في مستوى الجلوكوز في
+
+16
+00:01:23,740 --> 00:01:29,260
+الدم، هل هو زيادة الإنسولين ممكن يكون مثلاً، وبالتالي
+
+17
+00:01:29,260 --> 00:01:32,160
+بنحتاج إلى قياس مستويات الإنسولين في الدم.
+
+18
+00:01:32,160 --> 00:01:39,230
+Evaluation of Polycystic Ovary Syndrome، لأن النساء
+
+19
+00:01:39,230 --> 00:01:43,850
+اللي عندهم هذا الـsyndrome بيكون في عندهم insulin
+
+20
+00:01:43,850 --> 00:01:50,430
+resistance، وبالتالي من خلال قياس مستوى الـinsulin
+
+21
+00:01:50,430 --> 00:01:56,330
+وقياس الـfasting blood glucose ممكن نحسب ما يسمى
+
+22
+00:01:56,330 --> 00:02:04,790
+بـHOMA-IR، واللي من خلاله ممكن نشوف الـinsulin
+
+23
+00:02:04,790 --> 00:02:13,340
+resistance. طبعا فيه أنه الـformula لحساب الـHOMA-IR
+
+24
+00:02:13,340 --> 00:02:17,900
+زي ما واضح. ان الـHOMA-IR بتساوي جلوكوز ضرب
+
+25
+00:02:17,900 --> 00:02:23,660
+الإنسولين على أربعمية وخمسة، في حال كان إن الـunits
+
+26
+00:02:23,660 --> 00:02:28,600
+للي جلوكوز milligram per deciliter، أو جلوكوز ضرب
+
+27
+00:02:28,600 --> 00:02:33,510
+الإنسولين على اتنين و عشرين فاصلة خمسة، في حال كان
+
+28
+00:02:33,510 --> 00:02:39,410
+الـglucose units الـone millimole per liter، والـ
+
+29
+00:02:39,410 --> 00:02:44,730
+units لـ الـinsulin micro units لكل ml. طبعاً حسب
+
+30
+00:02:44,730 --> 00:02:49,950
+النتيجة اللي بتطلع. إذا كان يعني كان الشخص طبيعي
+
+31
+00:02:49,950 --> 00:02:53,530
+وما فيش أي insulin resistance بيكون عندنا الـHOMA-IR
+
+32
+00:02:53,530 --> 00:02:57,890
+أقل من واحد. early insulin resistance إذا كان أكثر
+
+33
+00:02:57,890 --> 00:03:04,490
+من 1.9، و significant insulin resistance إذا الـ
+
+34
+00:03:04,490 --> 00:03:07,470
+HOMA-IR أكثر من 2.9.
+
+35
+00:03:09,520 --> 00:03:13,100
+أيضاً ممكن اللي هو نستخدم قياس الإنسولين for
+
+36
+00:03:13,100 --> 00:03:16,600
+classification of diabetes mellitus، عشان نشوف إيش
+
+37
+00:03:16,600 --> 00:03:22,100
+سبب ارتفاع الـglucose في الدم، هل في عندي absolute
+
+38
+00:03:22,100 --> 00:03:26,760
+deficiency of الإنسولين أو عندي ممكن اللي هو نقص في
+
+39
+00:03:26,760 --> 00:03:34,430
+الإنسولين، وبناء عليه يعني أن .. أن .. أن قيم يعني
+
+40
+00:03:34,430 --> 00:03:38,570
+أن ..  نحدد إيش نوع الدايبيرتس، هل هو type one، هل
+
+41
+00:03:38,570 --> 00:03:46,690
+هو type two، هل هو MODY. أيضاً prediction of diabetes
+
+42
+00:03:46,690 --> 00:03:53,070
+mellitus. يبقى برضه ممكن يعني يصير اللي هو التوقع
+
+43
+00:03:53,070 --> 00:03:56,570
+أن هذا الشخص ممكن يصاب بـdiabetes mellitus
+
+44
+00:03:56,570 --> 00:04:01,910
+بالمستقبل. يعني في حال مثلاً أنه عندنا الـHOMA-IR
+
+45
+00:04:01,910 --> 00:04:06,330
+مثلاً مرتفع، وفي عندنا insulin resistance، ومعناه في
+
+46
+00:04:06,330 --> 00:04:10,200
+ممكن احتمال أن يصاب هذا الشخص مستقبلاً بالـ
+
+47
+00:04:10,200 --> 00:04:15,160
+diabetes mellitus. أيضاً في حالات اللي هو الـtype
+
+48
+00:04:15,160 --> 00:04:21,340
+1، زي ما قلنا أنه بيصير في عنا اللي هو تناقص في الـ
+
+49
+00:04:21,340 --> 00:04:24,100
+الـbeta cells، وبالتالي في الـconcentration
+
+50
+00:04:24,100 --> 00:04:26,480
+للإنسولين.
+
+51
+00:04:27,790 --> 00:04:32,790
+Assessment of beta cell activity. بقى بنقيم عمل الـ
+
+52
+00:04:32,790 --> 00:04:38,090
+beta cells اللي هي المنتجة لهرمون الإنسولين. أيضاً
+
+53
+00:04:38,090 --> 00:04:41,370
+Selection of optimal therapy for diabetes، بناء على
+
+54
+00:04:41,370 --> 00:04:45,990
+برضه الـconcentration للإنسولين، يعني زي في حالات
+
+55
+00:04:45,990 --> 00:04:49,450
+مثلاً الـtype 2 diabetes mellitus، والحالات
+
+56
+00:04:49,450 --> 00:04:55,450
+المتقدمة. يعني من خلال قياسنا للإنسولين بنشوف إذا
+
+57
+00:04:55,450 --> 00:05:02,860
+كان هذا المريض محتاج أنه نعطيه exogenous insulin، أو
+
+58
+00:05:02,860 --> 00:05:10,180
+لـinvestigation of insulin resistance، اللي هو برضه
+
+59
+00:05:10,180 --> 00:05:10,980
+يعني ممكن
+
+60
+00:05:15,190 --> 00:05:19,970
+اللي زي ما شوفنا فيه اللي هو حالة الـPolycystic
+
+61
+00:05:19,970 --> 00:05:24,610
+Ovary Syndrome، اللي من خلال قياسنا لـHOMA-IR.
+
+62
+00:05:24,610 --> 00:05:28,730
+Prediction of the Development of Coronary Artery
+
+63
+00:05:28,730 --> 00:05:34,450
+Disease، لأنه في هنا علاقة أكيد بين الـinsulin
+
+64
+00:05:34,450 --> 00:05:40,650
+resistance، واللي هو الـatherosclerosis، وبالتالي
+
+65
+00:05:40,650 --> 00:05:44,170
+الـcoronary artery disease. طبعاً معاه اللي هو
+
+66
+00:05:44,170 --> 00:05:50,190
+ارتفاع أيضاً مستويات الدهون. بالنسبة للـproinsulin،
+
+67
+00:05:50,190 --> 00:05:56,630
+بنستخدمه في الـdiagnosis of beta cell tumors، لأن
+
+68
+00:05:56,630 --> 00:06:00,430
+في حالات الـbeta cell tumors في عنا مشكلة في
+
+69
+00:06:00,430 --> 00:06:06,970
+تحويل اللي هو الـproinsulin لإنسولين بشكل كامل،
+
+70
+00:06:06,970 --> 00:06:09,510
+وبالتالي بيكون في عنا ارتفاع في مستويات الـ
+
+71
+00:06:09,510 --> 00:06:14,350
+proinsulin. أيضاً ليه اللي هو الكشف عن حالات
+
+72
+00:06:14,350 --> 00:06:17,670
+الفميلة الـhyperproinsulinemia.
+
+73
+00:06:18,270 --> 00:06:22,770
+لو بهذه الحالة أيضاً أن الـinsulin is not
+
+74
+00:06:22,770 --> 00:06:28,830
+sufficiently processed before secretion. تمام؟
+
+75
+00:06:28,830 --> 00:06:31,770
+وبالتالي يعني بيكونش فيه عندنا تحويل بشكل كامل لـ
+
+76
+00:06:31,770 --> 00:06:37,270
+اللي هو الـpro-insulin إلى insulin، وبالتالي
+
+77
+00:06:37,270 --> 00:06:43,330
+بيكون عندنا الـ .. الكم الأكبر من الـ .. الـinsulin
+
+78
+00:06:43,330 --> 00:06:46,810
+الموجود هو immature form of insulin، أو اللي هو الـ
+
+79
+00:06:46,810 --> 00:06:48,950
+pro-insulin.
+
+80
+00:06:53,060 --> 00:07:01,060
+الـC-peptide، مشابه يعني لإيش بنستخدم الـ الإنسولين؟
+
+81
+00:07:01,060 --> 00:07:08,700
+أنه evaluation of fasting hypoglycemia، هل المشكلة
+
+82
+00:07:08,700 --> 00:07:13,040
+في الـC-peptide، اللي هو beta cell tumors.
+
+83
+00:07:17,470 --> 00:07:23,810
+يبقى بعض المرضى with beta cell اللي هو tumors، يعني
+
+84
+00:07:23,810 --> 00:07:29,450
+ممكن لو جينا قسنا مستويات الـinsulin يعني ما تكونش
+
+85
+00:07:29,450 --> 00:07:34,450
+حاسمة بما يتعلق بيه اللي هو موضوع الـdiagnosis،
+
+86
+00:07:34,450 --> 00:07:38,750
+لأنه في عندنا بعض الحالات ممكن يكون الـ
+
+87
+00:07:38,750 --> 00:07:43,490
+hyperinsulinism intermittent، يعني مش طول الوقت،
+
+88
+00:07:43,490 --> 00:07:48,630
+يعني ممكن يكون بشكل يعني متقطع، وبالتالي ممكن لما
+
+89
+00:07:48,630 --> 00:07:51,310
+نيجي نسحب عينة أو نقيس اللي هو الـinsulin ما نلاقيش
+
+90
+00:07:51,310 --> 00:07:55,710
+أنه الـinsulin مرتفع، وبالتالي بهذه الحالة ممكن
+
+91
+00:07:55,710 --> 00:07:58,770
+يكون عندنا قياس قياسنا لـالـC-peptide
+
+92
+00:07:58,770 --> 00:08:06,290
+concentration ممكن يكون مفيد أكثر. طبعاً للسبب إنه
+
+93
+00:08:06,290 --> 00:08:10,970
+عندنا الـconcentration لـC-peptide بتكون أعلى بـ
+
+94
+00:08:10,970 --> 00:08:14,890
+5 إلى 10 مرات من الـinsulin، لأنه زي ما حكينا
+
+95
+00:08:14,890 --> 00:08:21,170
+سابقا أن الـC-peptide has a longer half life.
+
+96
+00:08:21,170 --> 00:08:25,350
+عندنا أيضاً ممكن يصير فيه اللي هو evaluation
+
+97
+00:08:25,350 --> 00:08:30,450
+لـinfectious اللي
+
+98
+00:08:30,450 --> 00:08:34,910
+هو بيكون عندنا fasting hypoglycemia، وهذا اللي هو
+
+99
+00:08:34,910 --> 00:08:40,990
+بيكون طبعاً بسبب اللي هو الـexogenous insulin.
+
+100
+00:08:40,990 --> 00:08:46,580
+تمام، من خلال القياس اللي هو الـC-peptide يعني ممكن
+
+101
+00:08:46,580 --> 00:08:51,160
+نحدد أنه هل الـ .. الـ .. المشكلة هل بـ .. اللي هو الـ
+
+102
+00:08:51,160 --> 00:08:56,440
+endogenous insulin، أو بـ .. المشكلة بالـexogenous
+
+103
+00:08:56,440 --> 00:09:01,780
+insulin. طبعاً بهذه الحالة بيكون أن الـinsulin
+
+104
+00:09:01,780 --> 00:09:06,920
+concentration high، لكن الـC-peptide values حتكون
+
+105
+00:09:06,920 --> 00:09:11,060
+low. برضه زي ما حكينا أنه يعني ممكن تكون مشابهة
+
+106
+00:09:11,060 --> 00:09:13,860
+لاستخداماتنا للإنسولين: Classification of diabetes
+
+107
+00:09:13,860 --> 00:09:17,500
+mellitus، Assessment of beta cell activity،
+
+108
+00:09:17,500 --> 00:09:22,250
+Obtaining insurance coverage for insulin pump. يعني
+
+109
+00:09:22,250 --> 00:09:26,090
+بعض اللي هو شركات التأمين يعني هذا بيكون ممكن في
+
+110
+00:09:26,090 --> 00:09:33,310
+الخارج، بعض شركات التأمين بتطلب زي اللي هو دليل على
+
+111
+00:09:33,310 --> 00:09:39,750
+أنه هذا المريض بيحتاج فعلياً إلى صرف insulin pump
+
+112
+00:09:39,750 --> 00:09:44,950
+له، وبالتالي بيحتاجوا اللي هو فحص الـC-peptide.
+
+113
+00:09:45,650 --> 00:09:49,630
+أيضاً برضه الـC-peptide اللي هو دور في الـ
+
+114
+00:09:49,630 --> 00:09:54,350
+monitoring of therapy. يعني في حالات البنكرياتكتومي
+
+115
+00:09:54,350 --> 00:09:58,410
+اللي هو لما بيصير في عنا استئصال لـالـ
+
+116
+00:09:58,410 --> 00:10:04,130
+الـpancreas، يعني ممكن نأكد أنه اللي هو استئصال
+
+117
+00:10:04,130 --> 00:10:09,950
+بشكل كامل من خلال اللي هو قياسنا لـالـC-peptide.
+
+118
+00:10:09,950 --> 00:10:13,190
+تمام؟ يبقى عدا موجود اللي هو الـC-peptide هذا
+
+119
+00:10:13,190 --> 00:10:18,170
+حيكون أنه صار هنا الموضوع اللي هو الاستئصال بشكل
+
+120
+00:10:18,170 --> 00:10:24,410
+كامل، أو في بعض الحالات ممكن تصير فيها اللي هو
+
+121
+00:10:24,410 --> 00:10:29,190
+partial pancreatectomy، اللي هو يعني تم استئصال
+
+122
+00:10:29,190 --> 00:10:33,570
+ممكن جزء من اللي هو الـpancreas. إذا كان عندنا
+
+123
+00:10:33,570 --> 00:10:38,420
+مشكلة موجودة بالـexocrine glands للبنكرياس،
+
+124
+00:10:38,420 --> 00:10:43,900
+وبالتالي يعني ممكن نقيس اللي هو الـC-peptide عشان
+
+125
+00:10:43,900 --> 00:10:48,060
+نشوف إذا كان البنكرياس يعني مازال قادر ممكن على
+
+126
+00:10:48,060 --> 00:10:53,720
+إنتاج اللي هو الإنسولين أو لأ. أيضاً بما يتعلق بالـ
+
+127
+00:10:53,720 --> 00:11:00,060
+transplantation of islets of Langerhans. تمام، إذا كان
+
+128
+00:11:00,060 --> 00:11:05,160
+صار فيه عملية تسمى transplantation لـislets of
+
+129
+00:11:05,160 --> 00:11:10,360
+Langerhans، عشان نشوف إذا كان هذه الـislets يعني
+
+130
+00:11:10,360 --> 00:11:18,500
+أخذت مكانها وبدأت تنتج الـinsulin أو لأ. برضه بما
+
+131
+00:11:18,500 --> 00:11:24,060
+يتعلق بالـmonitoring therapy، والـimmunomodulation
+
+132
+00:11:24,060 --> 00:11:31,040
+of type 1. وفي الـimmunomodulation يعني ممكن تعتبر
+
+133
+00:11:31,040 --> 00:11:41,960
+part of immunotherapy للأشخاص ممكن اللي يعني عندهم
+
+134
+00:11:41,960 --> 00:11:45,440
+الـtype 1، وعنده beta cells، أو تم اكتشاف ممكن
+
+135
+00:11:45,440 --> 00:11:49,400
+المرض عندهم اللي هو type 1، وعنده beta cells، لكن
+
+136
+00:11:49,400 --> 00:11:55,950
+يعني ما زال عندنا الـbeta cells ممكن يعني يتم
+
+137
+00:11:55,950 --> 00:12:05,350
+استرجاع جزء منها، وبالتالي يعني بيتم اللي هو يعني
+
+138
+00:12:05,350 --> 00:12:12,810
+زي تثبيت لجهاز المناعة، وبالتالي يعني عشان نحافظ
+
+139
+00:12:12,810 --> 00:12:19,010
+ممكن على اللي المتبقي من الـbeta-cells اللي
+
+140
+00:12:19,010 --> 00:12:23,590
+موجودة، وبالتالي بنقيس برضه الـC-peptide عشان نشوف
+
+141
+00:12:23,590 --> 00:12:32,090
+هل الـimmune modulation يعني في استجابة أو لأ. عندنا
+
+142
+00:12:32,090 --> 00:12:36,070
+أيضاً الـglucagon، من الفحصات اللي بيتم، وهذا
+
+143
+00:12:36,070 --> 00:12:41,910
+بيستخدم للـdiagnosis of alpha cell tumors،
+
+144
+00:12:41,910 --> 00:12:45,350
+pathogenesis
+
+145
+00:12:45,350 --> 00:12:54,020
+of type 1 diabetes mellitus. حكينا سابقاً أنه السبب
+
+146
+00:12:54,020 --> 00:12:59,900
+ليحدوث الـtype 1 diabetes mellitus ممكن يكون بسبب
+
+147
+00:12:59,900 --> 00:13:03,740
+اللي هو الـautoimmune destruction of beta cells،
+
+148
+00:13:03,740 --> 00:13:11,500
+وطبعاً السبب هذا اللي هو بيمثل يعني الجزء الأكبر
+
+149
+00:13:11,500 --> 00:13:17,380
+من الإصابات بالـtype 1، وعندنا الجزء الآخر اللي هو
+
+150
+00:13:17,380 --> 00:13:20,440
+بيكون السبب غير معروف، اللي هو الـidiopathic.
+
+151
+00:13:22,670 --> 00:13:25,270
+In the vast majority of patients, destruction
+
+152
+00:13:25,270 --> 00:13:31,910
+is mediated by T cells. وهذا النوع اللي هو المسؤول
+
+153
+00:13:31,910 --> 00:13:36,890
+عنه الـautoimmune destruction، بنطلق عليه أيضاً
+
+154
+00:13:36,890 --> 00:13:45,470
+type 1a أو immune mediated diabetes. الآن الخلايا
+
+155
+00:13:45,470 --> 00:13:51,500
+اللي فعلياً بهاجمة جهاز المناعة هي خلايا الـbeta
+
+156
+00:13:51,500 --> 00:13:56,040
+cells، بدون ما يكون فيه أي تأثير على الـalpha
+
+157
+00:13:56,040 --> 00:13:59,880
+cells أو الـdelta cells. يبقى الـalpha والـ
+
+158
+00:13:59,880 --> 00:14:04,260
+delta cells are preserved، يتم اللي هو المحافظة
+
+159
+00:14:04,260 --> 00:14:10,040
+عليهم. The islet cells have a chronic mononuclear
+
+160
+00:14:10,040 --> 00:14:15,560
+cell infiltrate. يبقى بيصير فيه عندنا infiltration
+
+161
+00:14:15,560 --> 00:14:19,800
+اللي هو lymphocytic infiltration لـ islets of
+
+162
+00:14:19,800 --> 00:14:24,840
+Langerhans. وهذه اللي هو بيطلق عليها insulitis،
+
+163
+00:14:24,840 --> 00:14:28,740
+اللي هو inflammation of the islets of Langerhans،
+
+164
+00:14:28,740 --> 00:14:32,580
+وزي ما قلنا بيحصل فيها اللي هو lymphocytic
+
+165
+00:14:32,580 --> 00:14:34,180
+infiltration.
+
+166
+00:14:36,990 --> 00:14:43,570
+الـautoimmune destruction، الـprocess اللي حتؤدي
+
+167
+00:14:43,570 --> 00:14:46,810
+إلى طبعاً destruction of beta cells، وبالتالي الـ
+
+168
+00:14:46,810 --> 00:14:52,710
+type 1 diabetes.  المدة اللي حتأخذها بتختلف
+
+169
+00:14:52,710 --> 00:14:58,810
+يعني من months لـyears، وهذا يعني مرتبط ممكن بأسباب
+
+170
+00:14:58,810 --> 00:15:07,890
+مختلفة، ممكن منها عمر الشخص المصاب. الآن الـ الـ
+
+171
+00:15:07,890 --> 00:15:12,410
+clinical presentations، فعلياً، والـdiagnosis ممكن
+
+172
+00:15:12,410 --> 00:15:18,370
+أو الـsymptoms ممكن تظهر لما يصير فيه أن 80 إلى 90
+
+173
+00:15:18,370 --> 00:15:26,650
+بالمائة من الـbeta cells يعني بالفعل صار نقص فيها.
+
+174
+00:15:29,000 --> 00:15:32,360
+معدل تدمير خلايا بيتا لدى الأطفال مختلف، وعادة
+
+175
+00:15:32,360 --> 00:15:37,840
+أسرع في الأطفال الصغار. اللي كمان اللي هو زي ما
+
+176
+00:15:37,840 --> 00:15:42,980
+قلنا العمر بيفرق، وعندنا الـdestruction لـالـbeta
+
+177
+00:15:42,980 --> 00:15:51,360
+cells هذا بيكون أسرع عند الأطفال. في حالة اللي هو
+
+178
+00:15:51,360 --> 00:15:55,920
+الـautoimmune destruction لـالـbeta cells، بيتم
+
+179
+00:15:55,920 --> 00:15:59,680
+إنتاج العديد من الـantibodies.
+
+180
+00:16:02,580 --> 00:16:07,080
+وممكن من خلال الكشف عن هذه الـantibodies يتم
+
+181
+00:16:07,080 --> 00:16:14,400
+تأكيد الإصابة بالـtype 1 diabetes mellitus. وهذه
+
+182
+00:1
+
+223
+00:19:37,980 --> 00:19:44,280
+الذي diagnosed type 1 diabetes mellitus في أن بعض
+
+224
+00:19:44,280 --> 00:19:49,160
+الحالات التي ممكن يعني تشخص بداية على أنها type 2
+
+225
+00:19:49,160 --> 00:19:50,360
+diabetes mellitus
+
+226
+00:19:53,000 --> 00:19:56,220
+الذي هو apparently يعني type 2 diabetes mellitus
+
+227
+00:19:56,220 --> 00:20:05,920
+لكن إذا تم الذي هو الفحص الجاد لـ GAD65 antibodies وطبعا
+
+228
+00:20:05,920 --> 00:20:11,080
+تم الكشف عن هذه الـ antibodies عند هذا الذي هو الـ
+
+229
+00:20:11,080 --> 00:20:15,620
+patient ،بمعنى أن diagnosis الصحيح سيكون الذي
+
+230
+00:20:15,620 --> 00:20:17,220
+هو type 1 diabetes
+
+231
+00:20:24,180 --> 00:20:31,160
+الذي زي ما قلنا لو يعني بعد فترة من الزمن سنجد
+
+232
+00:20:31,160 --> 00:20:36,680
+أن هذا الشخص فعليا الذي هو عنده type 1 diabetes
+
+233
+00:20:36,680 --> 00:20:45,610
+mellitus ومش type 2. ذكرنا سابقا أن الـ type 2
+
+234
+00:20:45,610 --> 00:20:48,670
+diabetes mellitus patients يعني ممكن في مراحل
+
+235
+00:20:48,670 --> 00:20:54,490
+متقدمة يعني يصبحوا يعتمدوا على الـ exogenous
+
+236
+00:20:54,490 --> 00:20:59,990
+insulin. لكن في بعض الحالات التي هو الـ type 2
+
+237
+00:20:59,990 --> 00:21:06,430
+diabetes mellitus ممكن الـ progression إلى الـ
+
+238
+00:21:06,430 --> 00:21:13,450
+disease تكون سريعة يعني ولا يحتاجون مدة طويلة حتى
+
+239
+00:21:13,450 --> 00:21:19,070
+الذي هو يحتاجوا إلى exogenous insulin. الآن ممكن
+
+240
+00:21:19,070 --> 00:21:23,450
+نكشف عن هذه الفئة من المرضى الذين عندهم type 2
+
+241
+00:21:23,450 --> 00:21:30,410
+diabetes mellitus لكن ممكن يعني يصير الذي هو
+
+242
+00:21:30,410 --> 00:21:36,610
+deficiency  للانسولين مستقبلا من خلال فحصنا للـ
+
+243
+00:21:36,610 --> 00:21:41,410
+GAD65 Antibodies. يبقى الـ Type 2 Diabetes mellitus الـ
+
+244
+00:21:41,410 --> 00:21:45,010
+patients الذين نكشف عن وجود الذي هو الـ GAD65
+
+245
+00:21:45,010 --> 00:21:48,230
+Antibodies عندهم، يبقى هؤلاء ممكن يصير عندنا
+
+246
+00:21:48,230 --> 00:21:53,590
+progression بشكل سريع
+
+247
+00:21:54,610 --> 00:22:01,010
+ويتحولوا إلى طبعا الاعتماد على الانسولين بشكل كامل
+
+248
+00:22:01,010 --> 00:22:06,510
+عندنا أيضا Antibodies التي تُفرز ضد
+
+249
+00:22:06,510 --> 00:22:12,410
+insulinoma associated antigens،  الـ IA-2A  و IA
+
+250
+00:22:12,410 --> 00:22:18,250
+-2β. هذه الأنتيجينات هي عبارة عن Transmembrane
+
+251
+00:22:18,250 --> 00:22:23,030
+proteins of dead core vesicles
+
+252
+00:22:25,360 --> 00:22:32,060
+الآن عندما يصير لدينا مهاجمة لهذه الأنتيجينات من
+
+253
+00:22:32,060 --> 00:22:38,660
+قبل الـ antibodies التي تتكون ضدها، هذا يؤدي إلى
+
+254
+00:22:39,840 --> 00:22:45,560
+تقليل عدد الذي هو الـ dense core vesicles التي هي
+
+255
+00:22:45,560 --> 00:22:50,300
+التي تحتوي على الهرمونات، وبهذه الحالة ما زال  نحكي
+
+256
+00:22:50,300 --> 00:22:54,540
+على الـ islets of Langerhans  ونحكي على هرمونات
+
+257
+00:22:54,540 --> 00:23:00,040
+مثل الذي هو الانسولين في الـ beta cells. يعني الـ
+
+258
+00:23:00,040 --> 00:23:04,600
+antibodies التي تُفرز ضد هذه الأنتيجينات تقلل من
+
+259
+00:23:04,600 --> 00:23:10,980
+الـ dense core vesicles وبالتالي تقلل من الـ
+
+260
+00:23:10,980 --> 00:23:17,640
+secretion of insulin hormones. هذه الـ antibodies
+
+261
+00:23:17,640 --> 00:23:21,140
+have been detected in more than 50% of newly
+
+262
+00:23:21,140 --> 00:23:26,980
+diagnosed type 1 diabetes mellitus patients. عندنا
+
+263
+00:23:26,980 --> 00:23:32,680
+أيضا Antibodies أخرى التي تُنتج ضد
+
+264
+00:23:32,680 --> 00:23:38,580
+the zinc transporter الذي عبارة عن Transmembrane، a
+
+265
+00:23:38,580 --> 00:23:44,420
+protein responsible for the influx of zinc and
+
+266
+00:23:44,420 --> 00:23:51,300
+other ions. Was
+
+267
+00:23:51,300 --> 00:23:55,840
+identified in 2007 as a major auto-antigen in type
+
+268
+00:23:55,840 --> 00:23:57,880
+1 diabetes mellitus
+
+269
+00:24:00,080 --> 00:24:05,160
+الأقل تميزا من  الارتباطات الأخرى في داء السكري، يعني
+
+270
+00:24:05,160 --> 00:24:10,380
+يحتاج إلى عملية تحقيقها بشكل أوضح
+
+271
+00:24:13,810 --> 00:24:19,890
+في 60% من الحالات التي يتم اكتشافها من الذي هو الـ
+
+272
+00:24:19,890 --> 00:24:26,770
+Type 1 diabetes mellitus نجد أن فيه الذي هو
+
+273
+00:24:26,770 --> 00:24:33,970
+antibodies ضد الـ Zinc Transporter. طبعا مقارنة
+
+274
+00:24:33,970 --> 00:24:39,950
+بأقل من 2% عند الضوابط أو الذي هو 3% عند
+
+275
+00:24:39,950 --> 00:24:43,950
+الأشخاص المصابين بالـ Type 2 Diabetes Mellitus
+
+276
+00:24:43,950 --> 00:24:49,890
+بنسبة عالية التي هو 60 إلى 80% من المرضى الذين يعانون من
+
+277
+00:24:49,890 --> 00:24:55,070
+Type 1 Diabetes Mellitus نجد أن عندهم هذا
+
+278
+00:24:55,070 --> 00:25:01,080
+الـ auto antigen. أهم الـ antibodies  لـ Zinc
+
+279
+00:25:01,080 --> 00:25:06,740
+Transporter يتم الكشف عنها في حوالي 26% من المصابين بـ
+
+280
+00:25:06,740 --> 00:25:09,460
+Type 1 Diabetes Mellitus، هذه نقاط مفارقة
+
+281
+00:25:09,460 --> 00:25:14,300
+لفئة أخرى من  الـ auto antibodies التي
+
+282
+00:25:14,300 --> 00:25:20,200
+ذكرناها سابقا. قد نجد أن شخص لديه Type 1
+
+283
+00:25:20,200 --> 00:25:24,450
+Diabetes Mellitus و يكون سالبا للـ auto antibodies
+
+284
+00:25:24,450 --> 00:25:30,910
+الأخرى جميعها لكن يكون موجبا للـ Zinc transporter
+
+285
+00:25:30,910 --> 00:25:32,270
+antibodies
+
+286
+00:25:36,200 --> 00:25:41,300
+طبعا يمكن الكشف عن هذه الـ Antibodies المختلفة
+
+287
+00:25:41,300 --> 00:25:45,940
+باستخدام الـ Radio Immunoassay، باستخدام الـ ELISA،
+
+288
+00:25:45,940 --> 00:25:51,280
+وفي تقنية جديدة تسمى Plasmonic Chip Based
+
+289
+00:25:51,280 --> 00:25:56,980
+Assay يمكن استخدامها للكشف عن الـ Antibodies
+
+290
+00:25:56,980 --> 00:25:58,620
+المختلفة
+
+291
+00:26:00,600 --> 00:26:04,400
+بما يتعلق بالـ Genetics و الـ Type 1 diabetes
+
+292
+00:26:04,400 --> 00:26:12,220
+mellitus، الـ Genetics يعني العوامل الوراثية تلعب دورا أقل في
+
+293
+00:26:12,220 --> 00:26:17,580
+الـ Type 1 diabetes mellitus إذا ما قورن الأمر
+
+294
+00:26:17,580 --> 00:26:20,320
+بـ الـ Type 2 diabetes mellitus
+
+295
+00:26:22,350 --> 00:26:24,850
+الـ susceptibility to type 1 diabetes mellitus is
+
+296
+00:26:24,850 --> 00:26:27,390
+inherited but the mode of inheritance is complex
+
+297
+00:26:27,390 --> 00:26:31,730
+and has not been identified، يعني لا زلنا نحتاج إلى المزيد من
+
+298
+00:26:31,730 --> 00:26:37,010
+research  لفهم علاقة  الـ genetics بالـ
+
+299
+00:26:37,010 --> 00:26:40,890
+type 1 diabetes mellitus. it is a multi-genetic
+
+300
+00:26:40,890 --> 00:26:46,170
+trait، يعني أن أكثر من جين له علاقة بـ
+
+301
+00:26:46,720 --> 00:26:50,940
+الإصابة،  And the major locus is the major
+
+302
+00:26:50,940 --> 00:26:56,740
+histocompatibility complex on chromosome 6. إن
+
+303
+00:26:56,740 --> 00:27:05,700
+أيضا 11 موقعا آخر على 9 كروموزومات أيضا يلعب دورا
+
+304
+00:27:05,700 --> 00:27:16,510
+ويرتبط بـ regulatory region  لجين الإنسولين، الـ
+
+305
+00:27:16,510 --> 00:27:16,750
+Human Leukocyte Antigen HLA-DQ-DR، الهيومان
+
+306
+00:27:16,750 --> 00:27:22,050
+Leukocyte Antigen HLA-DQ-DR، الهيومان ليكوسايت
+
+307
+00:27:22,050 --> 00:27:22,070
+-DR، الهيومان ليكوسايت انتيجين HLA-DQ-DR، الهيومان
+
+308
+00:27:22,070 --> 00:27:22,950
+ليكوسايت انتيجين HLA-DQ-DR، الهيومان ليكوسايت
+
+309
+00:27:22,950 --> 00:27:27,310
+انتيجين HLA-DQ-DR، الهيومان ليكوسايت انتيجين HLA-DQ
+
+310
+00:27:27,310 --> 00:27:34,870
+-DR، الهيومان ليكوسايت انتيجين HLA-DQ-DR، الهيومان
+
+311
+00:27:34,870 --> 00:27:39,430
+ليكوسايت انتيجين HLA-DQ-DR، الهيومان ليكوسايت
+
+312
+00:27:39,430 --> 00:27:45,160
+انتيجين HLA-DQ. بما يتعلق بـ Concordance Rate بين
+
+313
+00:27:45,160 --> 00:27:53,840
+Identical Twins،  الذي هو تقريبا 30% فقط. يعني عند
+
+314
+00:27:53,840 --> 00:27:59,640
+الـ Identical Twins،  ممكن إذا كان عند 30% من الأشخاص
+
+315
+00:27:59,640 --> 00:28:02,240
+الذين هم Identical Twins إذا أحدهما لديه Type 1
+
+316
+00:28:02,240 --> 00:28:07,240
+Diabetes، الآخر سيكون أو سيصاب بـ Type 1 Diabetes
+
+317
+00:28:07,240 --> 00:28:08,220
+Mellitus
+
+318
+00:28:11,080 --> 00:28:15,340
+10% من المرضى الذين يعانون من type 1 diabetes
+
+319
+00:28:15,340 --> 00:28:19,360
+mellitus لديهم قريب من الدرجة الأولى مصاب
+
+320
+00:28:19,360 --> 00:28:27,520
+وعندنا أيضا مواقع أخرى غير الـ HLA التي هو
+
+321
+00:28:27,520 --> 00:28:32,320
+تقريبا 40 جينا
+
+322
+00:28:32,320 --> 00:28:39,440
+هذه لها علاقة، لكن these have a
+
+323
+00:28:39,440 --> 00:28:44,800
+smaller effects، التأثير أقل إذا ما قورن
+
+324
+00:28:44,800 --> 00:28:48,220
+بتأثير الـ HLA
+
+325
+00:28:50,900 --> 00:28:56,700
+يعني زي ما شفنا أن عندنا جينات
+
+326
+00:28:56,700 --> 00:29:01,820
+مختلفة وعديدة تلعب دورا في الإصابة بـ Type
+
+327
+00:29:01,820 --> 00:29:08,560
+1 Diabetes Mellitus وهذا يشير إلى أن جينات أكثر
+
+328
+00:29:08,560 --> 00:29:14,320
+سيتم التعرف عليها مستقبلا وربطها بـ Type 1
+
+329
+00:29:14,320 --> 00:29:21,030
+Diabetes Mellitus. بما يتعلق بـ Measurement أو الـ
+
+330
+00:29:21,030 --> 00:29:26,810
+Detection of Genetic Markers، هل هي مفيدة في المرحلة
+
+331
+00:29:26,810 --> 00:29:30,630
+الحالية؟ الـ Routine Measurement of Genetic Markers
+
+332
+00:29:30,630 --> 00:29:35,490
+ليس لها قيمة في الوقت الحالي لتشخيص أو
+
+333
+00:29:35,490 --> 00:29:38,850
+إدارة مرضى type 1 diabetes
+
+334
+00:29:38,850 --> 00:29:43,360
+mellitus، ولا لها فائدة في التشخيص
+
+335
+00:29:43,360 --> 00:29:50,300
+ولا لها فائدة أيضا في الإدارة أو في إدارة
+
+336
+00:29:50,300 --> 00:29:56,620
+المرضى. من ناحية أخرى،  البيئة والعوامل
+
+337
+00:29:56,620 --> 00:30:02,500
+البيئية، مع وجود الـ genetic
+
+338
+00:30:02,500 --> 00:30:06,820
+predisposition، العوامل البيئية تلعب دورا في
+
+339
+00:30:06,820 --> 00:30:13,440
+الإصابة. المقالات تُشير إلى أن مسببات بيئية مُهمة
+
+340
+00:30:13,440 --> 00:30:18,680
+في التسبب بداء السكري. ومن هذه الـ Environmental Factors
+
+341
+00:30:18,680 --> 00:30:23,860
+عندنا Viruses،  عندنا بعض
+
+342
+00:30:23,860 --> 00:30:30,940
+Chemicals،  ممكن الـ ... الـ ... الـ food،  العوامل
+
+343
+00:30:30,940 --> 00:30:34,960
+المختلفة هذه تلعب دورا.  الـ viruses مثل
+
+344
+00:30:34,960 --> 00:30:39,600
+الـ Rubella،  الـ Enterovirus،  الـ Coxsackie virus
+
+345
+00:30:39,600 --> 00:30:42,600
+have been implicated
+
+346
+00:30:45,160 --> 00:30:54,040
+والإصابة ببعض الفيروسات مرتبطة بوجود تشابه بين Viral
+
+347
+00:30:54,040 --> 00:31:02,180
+Protein و Beta Cell Protein.  يبقى الـ Viral
+
+348
+00:31:02,180 --> 00:31:05,180
+Protein shares amino acid sequence with a Beta
+
+349
+00:31:05,180 --> 00:31:10,280
+Cell Protein.  عند حدوث الإصابة بهذه الفيروسات
+
+350
+00:31:10,280 --> 00:31:12,320
+ممكن
+
+351
+00:31:15,000 --> 00:31:19,280
+يُحدث أو can initiate الذي هو immune response
+
+352
+00:31:19,280 --> 00:31:25,430
+against the beta cells. زي ما قلنا أن الـ Genetic
+
+353
+00:31:25,430 --> 00:31:30,310
+Factors، وجود الـ Genetic Factors يجعل الشخص
+
+354
+00:31:30,310 --> 00:31:35,990
+أكثر عرضة للإصابة، مثل الـ HLA-type عند
+
+355
+00:31:35,990 --> 00:31:40,770
+المريض وبالتالي تحدد الـ Genetic Factors مع
+
+356
+00:31:40,770 --> 00:31:43,770
+وجود الـ Environmental Factors، determine the
+
+357
+00:31:43,770 --> 00:31:49,390
+progression of the Beta Cell destruction. أيضا، زي
+
+358
+00:31:49,390 --> 00:31:53,290
+ما قلنا،  ممكن بعض الأطعمة تلعب دورا،
+
+359
+00:31:53,290 --> 00:31:56,770
+وخاصة عند الأطفال. يعني عندنا من خلال الـ
+
+360
+00:31:56,770 --> 00:32:01,970
+Epidemiological studies، they have implicated early
+
+361
+00:32:01,970 --> 00:32:05,470
+exposure to cow's milk as a trigger of type 1
+
+362
+00:32:05,470 --> 00:32:10,950
+diabetes mellitus. يبقى الأطفال إذا تم
+
+363
+00:32:10,950 --> 00:32:16,990
+إعطاؤهم الرضاعة والتي هي قبل أن يصل هذا الطفل
+
+364
+00:32:16,990 --> 00:32:26,400
+عمره السنة، إذا تم إعطاؤهم حليب بقر، فإنه
+
+365
+00:32:26,400 --> 00:32:30,300
+هؤلاء الأطفال  ممكن يصابوا مستقبلا بـ Type 1
+
+366
+00:32:30,300 --> 00:32:34,780
+diabetes mellitus. طبعا الأطفال الذين يكونون
+
+367
+00:32:34,780 --> 00:32:40,440
+جهازهم المناعي ليس ناضجا تماما، وبالتالي  ممكن يصير
+
+368
+00:32:40,440 --> 00:32:46,810
+لدينا absorption لبعض المكونات التي لا يجب أن
+
+369
+00:32:46,810 --> 00:32:50,350
+يحدث لها absorption، وبالتالي ممكن هذا يشكل
+
+370
+00:32:50,350 --> 00:32:55,430
+الـ trigger للإصابة بـ type 1 diabetes mellitus
+
+371
+00:32:55,430 --> 00:33:00,270
+this model is argumentative and has been debated
+
+372
+00:33:00,270 --> 00:33:06,710
+for decades. لا يزال ليس هناك إجماع على
+
+373
+00:33:06,710 --> 00:33:13,370
+فكرة حليب البقر، وهناك خلاف
+
+374
+00:33:13,370 --> 00:33:20,990
+وجدال كبير حول هذا الأمر. طيب،
+
+375
+00:33:20,990 --> 00:33:23,670
+بما يتعلق بـ pathogenesis of type 2 diabetes
+
+376
+00:33:23,670 --> 00:33:32,860
+mellitus، لدينا مشكلتان أساسيتان. المشكلة
+
+377
+00:33:32,860 --> 00:33:36,940
+الأولى هي الـ Insulin resistance،  عدم
+
+378
+00:33:36,940 --> 00:33:41,580
+استجابة الخلايا للانسولين بالشكل المطلوب. Decreased
+
+379
+00:33:41,580 --> 00:33:46,560
+ability of insulin to act on peripheral tissue. It
+
+380
+00:33:46,560 --> 00:33:49,300
+is thought by many to be the primary underlying
+
+381
+00:33:49,300 --> 00:33:55,200
+pathological process وهي هذه المشكلة الأساسية
+
+382
+00:33:56,680 --> 00:34:01,100
+والمشكلة الثانية Beta cell dysfunction،  عدم قدرة
+
+383
+00:34:01,100 --> 00:34:04,660
+البنكرياس على إنتاج كمية كافية من الانسولين لـ
+
+384
+00:34:04,660 --> 00:34:09,440
+تعويض Insulin resistance، بعدم قدرة
+
+385
+00:34:09,440 --> 00:34:13,980
+البنكرياس على التعامل مع المشكلة القائمة التي هي
+
+386
+00:34:13,980 --> 00:34:17,780
+الـ Insulin resistance
+
+387
+00:34:17,780 --> 00:34:23,320
+و الذي هو الزيادة في إفراز الانسولين لـ
+
+388
+00:34:23,320 --> 00:34:30,160
+التعويض عن Insulin resistance الذي حدث. يبقى المريض
+
+389
+00:34:30,160 --> 00:34:38,880
+في البداية يعاني من relative deficiency of insulin. تمام،
+
+390
+00:34:38,880 --> 00:34:42,180
+لأنه زي ما قلنا يبدأ حدوث Beta cell
+
+391
+00:34:42,180 --> 00:34:47,080
+dysfunction. وفي الحالات المتقدمة من الـ Type 2
+
+392
+00:34:47,080 --> 00:34:50,840
+diabetes mellitus،  ممكن أن ينتهي الأمر بالشخص إلى
+
+393
+00:34:50,840 --> 00:34:55,600
+Absolute deficiency ويصبح يعتمد على
+
+394
+00:34:55,600 --> 00:34:59,600
+الانسولين كعلاج أساسي
+
+395
+00:35:02,050 --> 00:35:07,070
+هناك جدال في هذه النقطة، الذي هو الـ
+
+396
+00:35:07,070 --> 00:35:10,250
+whether type 2 is due primarily to a defect in
+
+397
+00:35:10,250 --> 00:35:15,290
+beta cell secretion or to peripheral resistance to
+
+398
+00:35:15,290 --> 00:35:21,870
+insulin or to both. دائما كان هناك خلاف،  ما هو
+
+399
+00:35:21,870 --> 00:35:25,850
+الأول؟ هل الـ Insulin Resistance هي المشكلة الأولى
+
+400
+00:35:25,850 --> 00:35:29,790
+التي تنتج عنها Beta Cell Dysfunction، أم
+
+401
+00:35:29,790 --> 00:35:34,690
+المشكلة الأساسية هي الـ Beta Cell Dysfunction
+
+402
+00:35:34,690 --> 00:35:39,450
+وبالتالي  إفراز الإنسولين؟
+
+403
+00:35:42,920 --> 00:35:46,800
+البيانات المتوفرة تدعم فرضية أن مقاومة الإنسولين
+
+404
+00:35:46,800 --> 00:35:52,040
+المشكلة الأساسية من خلال المعلومات المتوفرة من
+
+405
+00:35:52,040 --> 00:35:59,080
+خلال  الـ research الذي تم بشكل كبير. عندنا الـ
+
+406
+00:35:59,080 --> 00:36:04,800
+data تدعم أن المشكلة الأساسية
+
+445
+00:39:28,290 --> 00:39:32,690
+render the beta cells increasingly unresponsive to
+
+446
+00:39:32,690 --> 00:39:38,350
+glucose يبقى الارتفاع المستمر في الجلوكوز تمام
+
+447
+00:39:38,350 --> 00:39:43,710
+بيزيد من اللي هو عدم استجابة خلايا الـ Beta cells
+
+448
+00:39:43,710 --> 00:39:49,830
+للارتفاع وهذا ما يسمى بالـ Glucotoxicity
+
+449
+00:39:49,830 --> 00:39:53,530
+The degree of dysfunction correlates with both
+
+450
+00:39:53,530 --> 00:39:57,500
+glucose concentration and a duration of
+
+451
+00:39:57,500 --> 00:40:02,520
+hyperglycemia هو كل ما زاد ارتفاع glucose كل
+
+452
+00:40:02,520 --> 00:40:09,500
+ما طولت مدة hyperglycemia طبعًا كل ما زادت
+
+453
+00:40:09,500 --> 00:40:18,040
+عندنا glucotoxicity وبالتالي اللي هو
+
+454
+00:40:18,040 --> 00:40:23,970
+progressive loss of beta cell function من ناحية
+
+455
+00:40:23,970 --> 00:40:28,630
+ثانية، عندنا أيضًا الزيادة في الـ Free fatty acids
+
+456
+00:40:28,630 --> 00:40:34,510
+يبقى برضه هذه بتلعب دور في الـ Beta cell failure
+
+457
+00:40:34,510 --> 00:40:41,130
+وهذا ما يُعرف بالـ Lipotoxicity عندنا أيضًا
+
+458
+00:40:41,130 --> 00:40:46,430
+المشكلة اللي ذكرناها سابقًا اللي هو الـ disruption
+
+459
+00:40:46,430 --> 00:40:51,580
+of the normal pulsatile release of insulin هذا ذكرنا
+
+460
+00:40:51,580 --> 00:40:54,380
+سابقا أن الناس اللي عندهم type 2 diabetes mellitus
+
+461
+00:40:54,380 --> 00:40:59,020
+اللي هو بيفقدوا الـ normal pulsatile release of
+
+462
+00:40:59,020 --> 00:41:05,880
+insulin and an increased ratio of plasma proinsulin
+
+463
+00:41:05,880 --> 00:41:12,340
+to insulin أيضًا الـ Insulin Resistance برضه زي ما
+
+464
+00:41:12,340 --> 00:41:20,140
+قلنا بيصير يعني جهد كبير على الـ Beta cells وهذا
+
+465
+00:41:20,140 --> 00:41:28,600
+برضه بيؤدي إلى النقص في الـ Beta cells عند الأشخاص
+
+466
+00:41:28,600 --> 00:41:35,120
+المصابين بالـ Type 2 Diabetes Mellitus النقطة
+
+467
+00:41:35,120 --> 00:41:39,010
+الثانية الـ Insulin Resistance defined as decreased
+
+468
+00:41:39,010 --> 00:41:44,050
+biological response to normal concentrations of
+
+469
+00:41:44,050 --> 00:41:48,350
+circulating insulin بيبطل فيه اللي هو
+
+470
+00:41:48,350 --> 00:41:50,890
+الاستجابة الطبيعية
+
+471
+00:41:55,010 --> 00:42:00,370
+من قبل الخلايا لـ  الـ... اللي هي الـ concentration
+
+472
+00:42:00,370 --> 00:42:03,650
+الطبيعية من الـ insulin يبقى الـ concentration
+
+473
+00:42:03,650 --> 00:42:09,310
+الطبيعية من الـ insulin بتبطل كافية للتعامل مع الـ
+
+474
+00:42:09,310 --> 00:42:12,970
+glucose اللي موجود في الدم طبعًا الـ insulin
+
+475
+00:42:12,970 --> 00:42:17,750
+resistance موجودة في اللي هو حالات مختلفة يعني أن
+
+476
+00:42:17,750 --> 00:42:26,180
+في obese persons, non-diabetic individuals, and in
+
+477
+00:42:26,180 --> 00:42:32,900
+patients with type 2 diabetes mellitus طيب
+
+478
+00:42:32,900 --> 00:42:37,780
+الآن المشكلة و الـ pathophysiologic defect يعني مش
+
+479
+00:42:37,780 --> 00:42:45,460
+... ما تمش... ما تمش تعرف عليه بشكل كامل لكن
+
+480
+00:42:45,460 --> 00:42:47,860
+الـ insulin resistance مشكلة الـ insulin resistance
+
+481
+00:42:47,860 --> 00:42:52,380
+usually attributed to a defect in insulin action
+
+482
+00:42:52,380 --> 00:42:57,750
+يبقى في عمل الانسولين، measurement of insulin
+
+483
+00:42:57,750 --> 00:43:01,110
+resistance in a routine clinical setting is
+
+484
+00:43:01,110 --> 00:43:05,290
+difficult واختيارات الـ Surrogate، بمعنى الـ
+
+485
+00:43:05,290 --> 00:43:08,950
+concentration of fasting insulin أو الـ Euglycemic
+
+486
+00:43:08,950 --> 00:43:14,910
+Insulin Clamp تستخدم لإعادة تجارب الأنسولين غير
+
+487
+00:43:14,910 --> 00:43:18,310
+مباشرة يبقى موضوع أن نقيس الـ insulin resistance
+
+488
+00:43:18,310 --> 00:43:23,710
+يعني موضوع صعب اللي هو نقيسه بطريقة مباشرة لكن
+
+489
+00:43:23,710 --> 00:43:27,950
+ممكن نقيس الـ insulin resistance بطريقة غير مباشرة
+
+490
+00:43:27,950 --> 00:43:32,770
+زي ما ذكرنا سابقًا ممكن من خلال الـ fasting اللي هو
+
+491
+00:43:32,770 --> 00:43:36,010
+انسولين مع الـ fasting glucose ممكن نحسب اللي هو
+
+492
+00:43:36,010 --> 00:43:41,550
+IR تمامًا اللي بتعبر عن الـ insulin resistance
+
+493
+00:43:43,840 --> 00:43:48,740
+اللي هم IR اختصار لـ Homeostatic Model
+
+494
+00:43:48,740 --> 00:43:54,560
+Assessment of Insulin Resistance من خلاله ممكن
+
+495
+00:43:54,560 --> 00:43:57,700
+نشوف
+
+496
+00:43:57,700 --> 00:44:01,540
+إذا كان الشخص عنده Insulin Resistance أو لا، هنا
+
+497
+00:44:01,540 --> 00:44:08,150
+أيضًا طريقة أخرى الـ Euglycemic Insulin Clamp وهي
+
+498
+00:44:08,150 --> 00:44:13,650
+دي يعني more invasive وبتحتاج اللي هو وقت أطول
+
+499
+00:44:13,650 --> 00:44:17,210
+لـ... يعني عملها
+
+500
+00:44:20,560 --> 00:44:23,320
+الـ Euglycemic clamp performed in the hospital
+
+501
+00:44:23,320 --> 00:44:28,720
+under close supervision و لازم بيه المستشفى و
+
+502
+00:44:28,720 --> 00:44:37,120
+الشخص طبعًا intravenously بيعطى infusion of insulin
+
+503
+00:44:37,120 --> 00:44:40,680
+constant intravenous infusion of insulin بيعطى
+
+504
+00:44:40,680 --> 00:44:50,090
+اللي هو كمية ثابتة من الأنسولين مع إعطائه لكميات أو
+
+505
+00:44:50,090 --> 00:44:54,590
+variable amounts of glucose يبقى بإيد بيصير فيه
+
+506
+00:44:54,590 --> 00:44:59,010
+أن constant infusion للأنسولين وبالإيد الثاني بنبدأ
+
+507
+00:44:59,010 --> 00:45:07,730
+نعطيه اللي هو كميات اللي هو من الـ glucose to
+
+508
+00:45:07,730 --> 00:45:10,250
+maintain blood glucose at a normal fasting
+
+509
+00:45:10,250 --> 00:45:13,940
+concentration لأن زي ما إحنا عارفين ما زال يعطينا
+
+510
+00:45:13,940 --> 00:45:17,220
+أنسولين بيبدأ الـ glucose بالتناقص بيبدأ نبدأ
+
+511
+00:45:17,220 --> 00:45:22,220
+نعطيه glucose اللي هو برضه intravenously ولازم
+
+512
+00:45:22,220 --> 00:45:25,760
+يعني بتتم في المستشفى لأنه يعني موضوع أن نعطي
+
+513
+00:45:25,760 --> 00:45:31,460
+المريض insulin طبعًا يعني مش سهل وممكن الشخص إذا
+
+514
+00:45:31,460 --> 00:45:35,320
+مافيش عندنا متابعة مستمرة للجلوكوز في الدم ممكن
+
+515
+00:45:35,320 --> 00:45:42,240
+الشخص يدخل في hypoglycemia يبقى insulin ومن ناحية
+
+516
+00:45:42,240 --> 00:45:47,680
+ثانية بنعطيه Glucose وفيه متابعة مستمرة لـ Glucose
+
+517
+00:45:47,680 --> 00:45:50,420
+concentration على أساس أن الـ Glucose
+
+518
+00:45:50,420 --> 00:45:54,900
+concentration تكون نفس الـ concentration اللي هو
+
+519
+00:45:54,900 --> 00:45:59,700
+في إذا كان الشخص صائم، يعني من 70 لـ 110
+
+520
+00:46:02,350 --> 00:46:04,370
+(Repeated word "لاجئ" removed)
+
+521
+00:46:04,370 --> 00:46:06,890
+(Repeated word "لاجئ" removed)
+
+522
+00:46:06,890 --> 00:46:11,430
+(Repeated word "لاجئ" removed)
+
+523
+00:46:11,430 --> 00:46:11,470
+(Repeated word "لاجئ" removed)
+
+524
+00:46:11,470 --> 00:46:12,930
+(Repeated word "لاجئ" removed)
+
+525
+00:46:12,930 --> 00:46:14,670
+(Repeated word "لاجئ" removed)
+
+526
+00:46:14,670 --> 00:46:15,210
+(Repeated word "لاجئ" removed)
+
+527
+00:46:15,210 --> 00:46:16,710
+(Repeated word "لاجئ" removed)
+
+528
+00:46:16,710 --> 00:46:19,530
+(Repeated word "لاجئ" removed)
+
+529
+00:46:19,530 --> 00:46:24,830
+(Repeated word "لاجئ" removed)
+
+530
+00:46:24,830 --> 00:46:29,280
+(Corrected spelling and grammar)  يُلاحظ أن... هؤلاء الناس سيكون عندهم
+
+531
+00:46:29,280 --> 00:46:35,880
+زيادة في الـ endogenous insulin تمامًا؟ والحالة
+
+532
+00:46:35,880 --> 00:46:41,900
+الثانية أن يكون عندنا اللي هو hyperglycemia يبقى
+
+533
+00:46:41,900 --> 00:46:47,900
+الحالة التي يكون فيها الـ... glucose concentration يعني
+
+534
+00:46:47,900 --> 00:46:51,900
+مرتفع وأكثر من اللي هو الـ normal fasting
+
+535
+00:46:51,900 --> 00:46:56,960
+concentration طبعًا مع الـ large doses of exogenous
+
+536
+00:46:56,960 --> 00:47:01,080
+insulin اللي زي ما قلنا تُحقن at a constant
+
+537
+00:47:01,080 --> 00:47:02,680
+concentration
+
+538
+00:47:05,210 --> 00:47:08,990
+يبقى المريض، زي ما قلنا بنعطيه الـ constant
+
+539
+00:47:08,990 --> 00:47:14,950
+insulin infusion وعندنا Variable glucose infusion
+
+540
+00:47:14,950 --> 00:47:19,570
+وعندنا اللي هو Frequent blood sampling عشان نقيس
+
+541
+00:47:19,570 --> 00:47:27,170
+مستوى الـ Glucose وعندنا زي ما قلنا Variable glucose
+
+542
+00:47:27,170 --> 00:47:30,350
+infusion يعني دائمًا فيه بناءً على الـ concentration
+
+543
+00:47:31,420 --> 00:47:36,580
+adjust glucose infusion to اللي هو clamp blood
+
+544
+00:47:36,580 --> 00:47:38,220
+glucose levels
+
+545
+00:47:40,900 --> 00:47:45,200
+يبقى من خلال الـ... الـ Euglycemic اللي هو glucose
+
+546
+00:47:45,200 --> 00:47:49,400
+clamp يبقى بنشوف بطريقة مباشرة measure of the
+
+547
+00:47:49,400 --> 00:47:53,400
+whole body glucose disposal بنشوف قد إيه الجسم قادر
+
+548
+00:47:53,400 --> 00:47:57,960
+على التخلص من الجلوكوز اللي قاعدين نعمله infusion
+
+549
+00:47:57,960 --> 00:48:02,060
+at a given level of insulinemia زي ما قلنا عندنا
+
+550
+00:48:02,060 --> 00:48:08,990
+اللي هو constant infusion of insulin under steady
+
+551
+00:48:08,990 --> 00:48:17,510
+state conditions وزي ما شفنا أن يعني ممكن إذا
+
+552
+00:48:17,510 --> 00:48:20,910
+كان عندنا الـ glucose concentration اللي هو طبيعي
+
+553
+00:48:20,910 --> 00:48:27,370
+مع زيادة في الـ insulin concentration أو مع الـ
+
+554
+00:48:27,370 --> 00:48:31,410
+exogenous insulin زي ما قلنا ممكن الجسم يكون برضه
+
+555
+00:48:31,410 --> 00:48:35,480
+غير قادر على التعامل مع كميات الـ glucose اللي
+
+556
+00:48:35,480 --> 00:48:41,740
+بتدخل للجسم لأن الـ Insulin Resistance عالية ذكرنا
+
+557
+00:48:41,740 --> 00:48:44,660
+أن في حالات أخرى برضه بيصير فيها اللي هو
+
+558
+00:48:44,660 --> 00:48:47,200
+Insulin Resistance ومنها دي الحالات اللي هو
+
+559
+00:48:47,200 --> 00:48:51,740
+Syndrome X أو ما يُعرف بالـ Metabolic Syndrome
+
+560
+00:48:51,740 --> 00:48:55,060
+a group of associated clinical and laboratory
+
+561
+00:48:55,060 --> 00:48:59,120
+findings وهؤلاء الأشخاص بيكون عندهم Insulin
+
+562
+00:48:59,120 --> 00:49:03,080
+Resistance بيكون فيه hyperinsulinemia ارتفاع في
+
+563
+00:49:03,080 --> 00:49:06,120
+اللي هو الـ insulin concentration، obesity، و
+
+564
+00:49:06,120 --> 00:49:10,060
+dyslipidemia اللي هو بتشمل ارتفاع في الـ
+
+565
+00:49:10,060 --> 00:49:18,620
+triglycerides، والانخفاض
+
+566
+00:49:18,620 --> 00:49:24,120
+في الـ high-density lipoprotein، وموجود أيضًا
+
+567
+00:49:24,120 --> 00:49:27,910
+hypertension الأشخاص الذين يمتلكون هذا الاضطراب
+
+568
+00:49:27,910 --> 00:49:34,510
+يكونون في فرصة أكبر للإصابة بأمراض القلب والأوعية الدموية طبعًا
+
+569
+00:49:34,510 --> 00:49:38,980
+بالنسبة لـ type 2 diabetes mellitus الـ Genetics
+
+570
+00:49:38,980 --> 00:49:44,740
+بتلعب دور أكبر يبقى وجود الـ Genetic factors بيخلي
+
+571
+00:49:44,740 --> 00:49:50,140
+الشخص طبعًا at higher risk للإصابة بـ Type 2
+
+572
+00:49:50,140 --> 00:49:53,060
+Diabetes Mellitus طبعًا مع وجود الـ Environmental
+
+573
+00:49:53,060 --> 00:49:59,040
+factors يعني العوامل البيئية  Environmental factors such as
+
+574
+00:49:59,040 --> 00:50:02,380
+diet and exercise are important determinants in
+
+575
+00:50:02,380 --> 00:50:05,860
+the pathogenesis of Type 2 Diabetes Mellitus يبقى
+
+576
+00:50:05,860 --> 00:50:11,020
+الـ diet والـ exercise وإذا كان الـ genetic
+
+577
+00:50:11,020 --> 00:50:18,640
+factors موجودة والشخص مش محافظ يعني على غذاء
+
+578
+00:50:18,640 --> 00:50:27,260
+صحي، مافيش exercise، حياته مافيش فيها حركة، فيه خمول،
+
+579
+00:50:27,260 --> 00:50:32,940
+يبقى معناه هذا الشخص يعني معرض بشكل كبير للإصابة
+
+580
+00:50:32,940 --> 00:50:38,900
+بـ type 2 diabetes mellitus (Repeated word "الوثيقة" removed)
+
+581
+00:50:38,900 --> 00:50:40,880
+(Repeated word "الوثيقة" removed)
+
+582
+00:50:40,880 --> 00:50:45,700
+(Repeated word "الوثيقة" removed)
+
+583
+00:50:45,700 --> 00:50:53,540
+(Repeated word "الوثيقة" removed)
+
+584
+00:50:53,540 --> 00:50:56,560
+(Repeated word "الوثيقة" removed)
+
+585
+00:50:57,020 --> 00:51:02,500
+يعني إما obese أو overweight، يبقى فيه عندنا علاقة
+
+586
+00:51:02,500 --> 00:51:06,900
+بين الـ obesity وبين الـ type 2 diabetes mellitus
+
+587
+00:51:10,840 --> 00:51:17,580
+طيب هل كل الأشخاص الـ... الـ... الـ obese يعني ممكن
+
+588
+00:51:17,580 --> 00:51:21,800
+يصابوا أو لازم يصابوا بـ type 2 diabetes mellitus؟
+
+589
+00:51:21,800 --> 00:51:28,220
+لأ يعني عندنا الـ... الـ... الأشخاص اللي هو الـ... الـ
+
+590
+00:51:28,220 --> 00:51:31,820
+obese, less than 15 percent of obese individuals
+
+591
+00:51:31,820 --> 00:51:39,180
+will develop diabetes تمامًا؟ جهد مرتبط بممكن الـ
+
+592
+00:51:39,180 --> 00:51:41,220
+Genetic factors، يعني ممكن الـ Genetic factors ما
+
+593
+00:51:41,220 --> 00:51:44,700
+تكونش موجودة، لكن يكون الشخص اللي هو obese ومافيش
+
+594
+00:51:44,700 --> 00:51:48,580
+exercise والأمور الأخرى، لكن إذا كان الـ Genetic
+
+595
+00:51:48,580 --> 00:51:55,180
+factors موجودة والشخص كان obese ومافيش exercise
+
+596
+00:51:55,180 --> 00:51:58,660
+وعوامل الخطر الأخرى، يبقى ممكن يصاب بالـ Type
+
+597
+00:51:58,660 --> 00:52:02,820
+2 Diabetes Mellitus، يبقى مش شرط أنّه عشان obese
+
+598
+00:52:02,820 --> 00:52:07,980
+يصاب، لكن زي ما قلنا أنّه إذا كانت الـ genetic factors
+
+599
+00:52:07,980 --> 00:52:12,520
+موجودة والشخص كان obese يبقى معناته الفرصة أكبر
+
+600
+00:52:12,520 --> 00:52:16,560
+أن يصاب بـ type 2 diabetes mellitus، إن 60% to
+
+601
+00:52:16,560 --> 00:52:20,320
+80% of patients with type 2 diabetes mellitus are
+
+602
+00:52:20,320 --> 00:52:21,200
+obese
+
+603
+00:52:26,260 --> 00:52:29,900
+يبقى ممكن الشخص يكون obese لكن ما عندهوش اللي هو
+
+604
+00:52:29,900 --> 00:52:34,340
+type 2 diabetes mellitus لكن يُلاحظ أنّه عنده
+
+605
+00:52:34,340 --> 00:52:39,220
+مشكلة اللي هو الـ carbohydrate tolerance في
+
+606
+00:52:39,220 --> 00:52:43,060
+التعامل مع الـ carbohydrates وهؤلاء الأشخاص يُلاحظ أنّه
+
+607
+00:52:43,060 --> 00:52:47,100
+عندهم hyperinsulinemia and are insulin
+
+608
+00:52:47,100 --> 00:52:48,220
+resistant
+
+609
+00:52:50,730 --> 00:52:54,910
+يبقى عندنا اللي هو الـ Obesity عامل في الـ Genetic
+
+610
+00:52:54,910 --> 00:52:57,250
+predisposition واللي هو الـ Family history طبعًا
+
+611
+00:52:57,250 --> 00:52:59,810
+يؤثر فيه  وأن الـ Duration
+
+612
+00:52:59,810 --> 00:53:04,850
+of Obesity والـ Distribution of Fat يبقى كمان
+
+613
+00:53:04,850 --> 00:53:09,290
+اللي هو مناطق توزيع الـ Fat وطبعًا إذا كان اللي
+
+614
+00:53:09,290 --> 00:53:14,570
+هو الـ Fat موزع في اللي هو الـ Trunk أو موزع في
+
+615
+00:53:14,570 --> 00:53:19,920
+اللي هو منطقة الوسط تمام يبقى هذه العوامل هي
+
+616
+00:53:19,920 --> 00:53:26,300
+عوامل الخطر للإصابة بـ Type 2 Diabetes Mellitus It is
+
+617
+00:53:26,300 --> 00:53:28,840
+important to note that intervention can delay or
+
+618
+00:53:28,840 --> 00:53:32,920
+prevent the onset of Type 2 Diabetes Mellitus طبعًا
+
+619
+00:53:32,920 --> 00:53:36,240
+إذا كان الشخص لم يُصاب بـ Type 2 Diabetes Mellitus
+
+620
+00:53:36,240 --> 00:53:43,930
+فهنا مرحلة الـ pre-diabetes الآن في هذه المرحلة إذا
+
+621
+00:53:43,930 --> 00:53:52,250
+كان صار فيه تدخل وصار فيه تنظيم للأكل صار فيه
+
+622
+00:53:52,250 --> 00:53:57,290
+exercise صار فيه حركة عند هذا الشخص بيصير ممكن
+
+623
+00:53:57,290 --> 00:54:02,330
+فعليًا يعني نؤخر أو نمنع من حدوث الـ Type 2
+
+624
+00:54:02,330 --> 00:54:08,730
+Diabetes Mellitus وهذا تم طبعًا إثباته من خلال
+
+625
+00:54:08,730 --> 00:54:10,170
+اللي هو الدراسات
+
+626
+00:54:12,560 --> 00:54:14,120
+(Repeated word "عملية" removed)
+
+627
+00:54:14,120 --> 00:54:14,700
+(Repeated word "عملية" removed)
+
+628
+00:54:14,700 --> 00:54:18,340
+(Repeated word "عملية" removed)
+
+629
+00:54:18,340 --> 00:54:20,260
+(Repeated word "عملية" removed)
+
+630
+00:54:20,260 --> 00:54:24,260
+(Repeated word "عملية" removed)
+
+631
+00:54:24,260 --> 00:54:24,320
+(Repeated word "عملية" removed)
+
+632
+00:54:24,320 --> 00:54:24,860
+(Repeated word
+
+667
+00:57:08,750 --> 00:57:13,570
+Genetic Factors وهذه الوضعيات أكثر مجنونة جنوناً
+
+668
+00:57:13,570 --> 00:57:18,390
+ومجموعة من الوضعيات الجنونية تتعامل مع انفلونات
+
+669
+00:57:18,390 --> 00:57:19,710
+إكسوجينية
+
+670
+00:57:27,310 --> 00:57:32,830
+factors وطبعاً من هذه الأمراض التي عندنا multi
+
+671
+00:57:32,830 --> 00:57:35,550
+genetic factors  ممكن التي تكون بتلعب دوراً مثل الـ
+
+672
+00:57:35,550 --> 00:57:38,150
+diabetes mellitus مثل الـ atherosclerosis،
+
+673
+00:57:38,150 --> 00:57:41,590
+hypertension، osteoporosis
+
+674
+00:57:44,400 --> 00:57:49,540
+طبعاً باستخدام ما هو طرق مختلفة تم الكشف عن يعني
+
+675
+00:57:49,540 --> 00:57:56,220
+عدد من الجينات التي لها علاقة بالإصابة بـ Type 2
+
+676
+00:57:56,220 --> 00:58:02,300
+Diabetes Mellitus وعندنا من الدراسات التي تم
+
+677
+00:58:02,300 --> 00:58:04,900
+استخدامها ما هو الـ Genome-wide Association
+
+678
+00:58:04,900 --> 00:58:13,900
+Studies وهذا النوع من الدراسات يعني طبعاً إشارةً أو
+
+679
+00:58:13,900 --> 00:58:21,260
+كان له دور كبير في ربط العديد من الـ genes بمرض
+
+680
+00:58:21,260 --> 00:58:24,580
+الذي هو الـ type 2 diabetes mellitus with more than
+
+681
+00:58:24,580 --> 00:58:29,180
+60 genetic loci now identified
diff --git a/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/0H-DC7bobLw_postprocess.srt b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/0H-DC7bobLw_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..58c201af27e25dc6b643c2f6caf85f76dc978957
--- /dev/null
+++ b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/0H-DC7bobLw_postprocess.srt
@@ -0,0 +1,2724 @@
+1
+00:00:01,500 --> 00:00:06,520
+بسم الله الرحمن الرحيم، نستكمل مع محاضرة الـ
+
+2
+00:00:06,520 --> 00:00:11,720
+diabetes mellitus clinical utility of measuring
+
+3
+00:00:11,720 --> 00:00:15,600
+insulin, proinsulin, c-peptide and glucagon، يبقى
+
+4
+00:00:15,600 --> 00:00:22,780
+إيش الهدف، إيش الفائدة من قياس هذه ال analytes
+
+5
+00:00:22,780 --> 00:00:28,450
+المختلفة؟طبعا بداية يعني احنا ممكن نتم القياس حسب
+
+6
+00:00:28,450 --> 00:00:38,050
+زي ما هنشوف الأسباب المختلفة لكن يعني مافيش role
+
+7
+00:00:38,050 --> 00:00:43,320
+أو مافيش فائدة من ال routine testingيعني احنا ممكن
+
+8
+00:00:43,320 --> 00:00:48,700
+نقيس و انشخص على سبيل المثال نعمل differential
+
+9
+00:00:48,700 --> 00:00:53,640
+diagnosis بين لو type 1 و type 2 طيب الآن هل يعني
+
+10
+00:00:53,640 --> 00:00:57,700
+نستمر بشكل روتيني بقياس مثلا الـ Insulin أو قياس
+
+11
+00:00:57,700 --> 00:01:01,800
+الـC-peptide؟ لأ، لا يوجد فائدة يبقى ليه الهدف
+
+12
+00:01:01,800 --> 00:01:05,900
+المرجع و بعد هيك يعني لا يوجد داعي ليه الـ routine
+
+13
+00:01:05,900 --> 00:01:14,420
+testing بما تعلق بالإنسولينعنا الأهداف لقياس
+
+14
+00:01:14,420 --> 00:01:19,860
+الإنسلين Evaluation of fasting hypoglycemia بعشان
+
+15
+00:01:19,860 --> 00:01:23,740
+نشوف إيش سبب اللي هو النقص في مستوى الجلوكوز في
+
+16
+00:01:23,740 --> 00:01:29,260
+الدم هل هو زيادة الإنسلين ممكن يكون مثلا وبالتالي
+
+17
+00:01:29,260 --> 00:01:32,160
+بنحتاج إلى قياس مستويات الإنسلين في الدم
+
+18
+00:01:32,160 --> 00:01:39,230
+Evaluation of Polycystic Ovary Syndromeلأن النساء
+
+19
+00:01:39,230 --> 00:01:43,850
+اللي عندهم هذا الـ syndrome بيكون في عندهم insulin
+
+20
+00:01:43,850 --> 00:01:50,430
+resistance وبالتالي من خلال قياس مستوى الـ insulin
+
+21
+00:01:50,430 --> 00:01:56,330
+وقياس ال fasting blood glucose ممكن نحسب ما يسمى
+
+22
+00:01:56,330 --> 00:02:04,790
+بـ HOMA IR واللي من خلاله ممكن نشوف ال insulin
+
+23
+00:02:04,790 --> 00:02:13,340
+resistanceطبعا فيه أنه ال formula لحساب ال home IR
+
+24
+00:02:13,340 --> 00:02:17,900
+زي ما واضحان ال home IR بتسوي لجلوكوز ضرب
+
+25
+00:02:17,900 --> 00:02:23,660
+الإنسولين على أربعمية وخمسة في حال كان إن ال units
+
+26
+00:02:23,660 --> 00:02:28,600
+للي جلوكوز milligram per deciliter أو لجلوكوز ضرب
+
+27
+00:02:28,600 --> 00:02:33,510
+الإنسولينعلى اتنين و عشرين point خمسة في حال كان
+
+28
+00:02:33,510 --> 00:02:39,410
+ال glucose units ال one millimole per literو ال
+
+29
+00:02:39,410 --> 00:02:44,730
+units لأ ال insulin micro units لكل mil طبعا حسب
+
+30
+00:02:44,730 --> 00:02:49,950
+النتيجة اللي بتطلع إذا كان يعني كان الشخص طبيعي
+
+31
+00:02:49,950 --> 00:02:53,530
+وفيش أي insulin resistance بيكون عندنا ال home IR
+
+32
+00:02:53,530 --> 00:02:57,890
+أقل من واحد early insulin resistance إذا كان أكتر
+
+33
+00:02:57,890 --> 00:03:04,490
+من 1.9 و significant insulin resistance إذا ال
+
+34
+00:03:04,490 --> 00:03:07,470
+home IR أكتر من 2.9
+
+35
+00:03:09,520 --> 00:03:13,100
+أيضا ممكن اللي هو نستخدم قياس الانسولين for
+
+36
+00:03:13,100 --> 00:03:16,600
+classification of diabetes mellitus عشان نشوف إيش
+
+37
+00:03:16,600 --> 00:03:22,100
+سبب ارتفاع لي glucose في الدم، هل في عندي absolute
+
+38
+00:03:22,100 --> 00:03:26,760
+deficiency of انسولين أو عندي ممكن اللي هو نقص في
+
+39
+00:03:26,760 --> 00:03:34,430
+الانسولينو بناء عليه يعني ان .. ان .. ان قيم يعني
+
+40
+00:03:34,430 --> 00:03:38,570
+ان .. انحدد ايش نوع ال دهبيروس هل هو type one هل
+
+41
+00:03:38,570 --> 00:03:46,690
+هو type two هل هو modyأيضًا prediction of diabetes
+
+42
+00:03:46,690 --> 00:03:53,070
+mellitus يبقى برضه ممكن يعني يصير اللي هو التوقع
+
+43
+00:03:53,070 --> 00:03:56,570
+أن هذا الشخص ممكن يصاب بـ diabetes mellitus
+
+44
+00:03:56,570 --> 00:04:01,910
+بالمستقبل يعني في حال مثلًا أنه عندنا الـ HOMA IR
+
+45
+00:04:01,910 --> 00:04:06,330
+مثلًا مرتفع وفي عندنا insulin resistance ومعناه في
+
+46
+00:04:06,330 --> 00:04:10,200
+ممكن احتمال أن يصاب هذا الشخص مستقبلاًبالـ
+
+47
+00:04:10,200 --> 00:04:15,160
+diabetes mellitus أيضًا في حالات اللي هو الـ type
+
+48
+00:04:15,160 --> 00:04:21,340
+1 زي ما قلنا أنه بيصير في عنا اللي هو تناقص في الـ
+
+49
+00:04:21,340 --> 00:04:24,100
+ال beta cells وبالتالي في ال concentration
+
+50
+00:04:24,100 --> 00:04:26,480
+للإنسلين
+
+51
+00:04:27,790 --> 00:04:32,790
+assessment of beta cell activity بقى بنقيم عمل الـ
+
+52
+00:04:32,790 --> 00:04:38,090
+beta cells اللي هي المنتجة لهرمون الإنسولين أيضا
+
+53
+00:04:38,090 --> 00:04:41,370
+selection of optimal therapy for diabetes بناء على
+
+54
+00:04:41,370 --> 00:04:45,990
+برضه ال concentration للإنسولين يعني زي في حالات
+
+55
+00:04:45,990 --> 00:04:49,450
+مثلا الـ type 2 diabetes mellitus والحالات
+
+56
+00:04:49,450 --> 00:04:55,450
+المتقدمة يعني من خلال قياسنا للإنسولين بنشوف إذا
+
+57
+00:04:55,450 --> 00:05:02,860
+كانهذا المريض محتاج انه نعطيه exogenous insulin او
+
+58
+00:05:02,860 --> 00:05:10,180
+لأ Invisitation of insulin resistance اللي هو برضه
+
+59
+00:05:10,180 --> 00:05:10,980
+يعني ممكن
+
+60
+00:05:15,190 --> 00:05:19,970
+اللي زي ما شوفنا فيه اللي هو حالة الـ Polycystic
+
+61
+00:05:19,970 --> 00:05:24,610
+Ovary Syndrome اللي من خلال قياسنا لهو ما AIR
+
+62
+00:05:24,610 --> 00:05:28,730
+Prediction of the Development of Coronary Artery
+
+63
+00:05:28,730 --> 00:05:34,450
+Disease لأنه فيه هناعلاقة أكيد بين ال insulin
+
+64
+00:05:34,450 --> 00:05:40,650
+resistance و اللي هو ال atherosclerosis وبالتالي
+
+65
+00:05:40,650 --> 00:05:44,170
+ال coronary artery disease طبعا معاه اللي هو
+
+66
+00:05:44,170 --> 00:05:50,190
+ارتفاع أيضا مستويات الدمونبالنسبة للـ Proinsulin
+
+67
+00:05:50,190 --> 00:05:56,630
+بنستخدمه في الـ diagnosis of beta cell tumors لأن
+
+68
+00:05:56,630 --> 00:06:00,430
+في حالات الـ beta cell tumors في عنا مشكلة في
+
+69
+00:06:00,430 --> 00:06:06,970
+تحويل اللي هو الـ Proinsulin لإنسلين بشكل كامل
+
+70
+00:06:06,970 --> 00:06:09,510
+وبالتالي بيكون في عنا ارتفاع في مستويات الـ
+
+71
+00:06:09,510 --> 00:06:14,350
+Proinsulin أيضًا ليه اللي هو الكشف عن حالات
+
+72
+00:06:14,350 --> 00:06:17,670
+الفميلة الـ hyperproinsulinemia
+
+73
+00:06:18,270 --> 00:06:22,770
+لو بهذه الحالة أيضًاأن ال insulin is not
+
+74
+00:06:22,770 --> 00:06:28,830
+sufficiently processed before secretion تمام؟
+
+75
+00:06:28,830 --> 00:06:31,770
+وبالتالي يعني بيكونش فيه عندنا تحويل بشكل كامل ل
+
+76
+00:06:31,770 --> 00:06:37,270
+.. اللي هو ال pro-insulin إلى insulin وبالتالي
+
+77
+00:06:37,270 --> 00:06:43,330
+بيكون عندنا ال .. الكم الأكبر من ال .. ال insulin
+
+78
+00:06:43,330 --> 00:06:46,810
+الموجود هو immature form of insulin أو اللي هو ال
+
+79
+00:06:46,810 --> 00:06:48,950
+pro-insulin
+
+80
+00:06:53,060 --> 00:07:01,060
+الـ C-peptide مشابه يعني لإيش بنستخدم الـ الانسلين
+
+81
+00:07:01,060 --> 00:07:08,700
+أنه evaluation of fasting hypoglycemia هل المشكلة
+
+82
+00:07:08,700 --> 00:07:13,040
+الـ C اللي هو beta cell ال tumors
+
+83
+00:07:17,470 --> 00:07:23,810
+يبقى بعض المرضى with beta cell اللي هو tumors يعني
+
+84
+00:07:23,810 --> 00:07:29,450
+ممكن لو جينا قصنا مستويات الـ Insulinيعني ما تكونش
+
+85
+00:07:29,450 --> 00:07:34,450
+حاسبة بما يتعلق بيه اللي هو موضوع الـ diagnosis
+
+86
+00:07:34,450 --> 00:07:38,750
+لأنه في عندنا بعض الحالات ممكن يكون الـ
+
+87
+00:07:38,750 --> 00:07:43,490
+hyperinsulinism intermittent يعني مش طول الوقت
+
+88
+00:07:43,490 --> 00:07:48,630
+يعني ممكن يكون بشكل يعني متقطعوبالتالي ممكن لما
+
+89
+00:07:48,630 --> 00:07:51,310
+نيجي نسحب عين أو نقيس اللي هو الـ Insulin مانلاقيش
+
+90
+00:07:51,310 --> 00:07:55,710
+إنه الـ Insulin مرتفع وبالتالي بهذه الحالة ممكن
+
+91
+00:07:55,710 --> 00:07:58,770
+يكون عندنا قياس قياسنا ل الـ C-peptide
+
+92
+00:07:58,770 --> 00:08:06,290
+concentration ممكن يكون مفيد أكتر طبعاً للسبب إنه
+
+93
+00:08:06,290 --> 00:08:10,970
+عندنا ال concentration لـ C-peptide بتكون أعلى بـ
+
+94
+00:08:10,970 --> 00:08:14,890
+5 إلى 10 مرات من الـ Insulin لأنه زي ما حكينا
+
+95
+00:08:14,890 --> 00:08:21,170
+سابقاً أن الـ C-peptidehas a longer half life
+
+96
+00:08:21,170 --> 00:08:25,350
+عندنا أيضًا ممكن يصير فيه اللي هو evaluation
+
+97
+00:08:25,350 --> 00:08:30,450
+لـinfectious اللي
+
+98
+00:08:30,450 --> 00:08:34,910
+هو يكون عندنا fasting hypoglycemia وهذا اللي هو
+
+99
+00:08:34,910 --> 00:08:40,990
+بيكون طبعًا بسبب اللي هو الـexogenous، الانسولين
+
+100
+00:08:40,990 --> 00:08:46,580
+تمام، من خلال القياس اللي هو الـC-peptideيعني ممكن
+
+101
+00:08:46,580 --> 00:08:51,160
+نحدد انه هل ال .. ال .. المشكلة هل ب .. اللي هو ال
+
+102
+00:08:51,160 --> 00:08:56,440
+endogenous insulin أو ب .. المشكلة بال exogenous
+
+103
+00:08:56,440 --> 00:09:01,780
+insulinطبعاً بهذه الحالة هيكون أن الـ Insulin
+
+104
+00:09:01,780 --> 00:09:06,920
+concentration high لكن الـ C-peptide values هتكون
+
+105
+00:09:06,920 --> 00:09:11,060
+low برضه زي ما حكينا أنه يعني ممكن تكون مشيابة
+
+106
+00:09:11,060 --> 00:09:13,860
+لاستخدام ماتنا للإنسلين Classification of diabetes
+
+107
+00:09:13,860 --> 00:09:17,500
+mellitus Assessment of beta cell activity
+
+108
+00:09:17,500 --> 00:09:22,250
+Obtaining insurance coverage for insulin pumpيعني
+
+109
+00:09:22,250 --> 00:09:26,090
+بعض اللي هو شركات التأمين يعني هذا بيكون ممكن في
+
+110
+00:09:26,090 --> 00:09:33,310
+الخارج بعض شركات التأمين بتطلب زي اللي هو دليل على
+
+111
+00:09:33,310 --> 00:09:39,750
+إنه هذا المريض بيحتاج فعليًا إلى صرف insulin pump
+
+112
+00:09:39,750 --> 00:09:44,950
+له وبالتالي بيحتاجوا اللي هو فحص الـ C-peptide
+
+113
+00:09:45,650 --> 00:09:49,630
+أيضًا برضه الـ C-peptide اللي هدور في الـ
+
+114
+00:09:49,630 --> 00:09:54,350
+monitoring of therapy يعني في حالات البنكريكتمي
+
+115
+00:09:54,350 --> 00:09:58,410
+اللي هو لما بيصير في عنا استقصال ليه اللي هو الـ
+
+116
+00:09:58,410 --> 00:10:04,130
+الـ pancreas يعني ممكن نأكد أنه اللي هو استقصال
+
+117
+00:10:04,130 --> 00:10:09,950
+بشكل كامل من خلال اللي هو قياسنا لـ الـ C-peptide
+
+118
+00:10:09,950 --> 00:10:13,190
+تمام؟ يبقى عدا موجود اللي هو الـ C-peptide هذا
+
+119
+00:10:13,190 --> 00:10:18,170
+هيأكد أنه صار هناالموضوع اللي هو الاستقصال بشكل
+
+120
+00:10:18,170 --> 00:10:24,410
+كامل أو في بعض الحالات ممكن تصير فيها اللي هو
+
+121
+00:10:24,410 --> 00:10:29,190
+partial pancreatectomy اللي هو يعني تم استقصال
+
+122
+00:10:29,190 --> 00:10:33,570
+ممكن جزء من اللي هو ال pancreas إذا كان عندنا
+
+123
+00:10:33,570 --> 00:10:38,420
+مشكلة موجودة بال Exocrineالـ glands للبنكرياز
+
+124
+00:10:38,420 --> 00:10:43,900
+وبالتالي يعني ممكن نقيص اللي هو الـ C-peptide عشان
+
+125
+00:10:43,900 --> 00:10:48,060
+نشوف إذا كان البنكرياز يعني مازال قادر ممكن على
+
+126
+00:10:48,060 --> 00:10:53,720
+إنتاج اللي هو الإنسلين أو لأ أيضا بما يتعلق بالـ
+
+127
+00:10:53,720 --> 00:11:00,060
+transplant لل eyelids of longer handsتمامي إذا كان
+
+128
+00:11:00,060 --> 00:11:05,160
+صار فيه عملية تسمى Transplantation ل Islets of
+
+129
+00:11:05,160 --> 00:11:10,360
+longer hands عشان نشوف إذا كان هذه ال islets يعني
+
+130
+00:11:10,360 --> 00:11:18,500
+أخدت مكانها و بدت تنتج ال insulin أو لأ برضه بما
+
+131
+00:11:18,500 --> 00:11:24,060
+يتعلق بال monitoring therapy و ال immunomodulation
+
+132
+00:11:24,060 --> 00:11:31,040
+of type 1وفي الـ Immunomodulation يعني ممكن تعتبر
+
+133
+00:11:31,040 --> 00:11:41,960
+part of immunotherapy للأشخاص ممكن اللي يعني عندهم
+
+134
+00:11:41,960 --> 00:11:45,440
+اللي وطيب و عنده beta smaletas أو تم اكتشاف ممكن
+
+135
+00:11:45,440 --> 00:11:49,400
+المرض عندهم اللي وطيب و عنده beta smaletas لكن
+
+136
+00:11:49,400 --> 00:11:55,950
+يعني ما زال عندناالـ Beta cells ممكن يعني يتم
+
+137
+00:11:55,950 --> 00:12:05,350
+استرجاع جزء منها وبالتالي يعني بيتم اللي هو يعني
+
+138
+00:12:05,350 --> 00:12:12,810
+زي تثبيت لجهاز المناعةوبالتالي يعني عشان نحافظ
+
+139
+00:12:12,810 --> 00:12:19,010
+ممكن على اللي المتبقي من الـ Beta-cells اللي
+
+140
+00:12:19,010 --> 00:12:23,590
+موجودة وبالتالي بنقيص برضه الـC-peptide عشان نشوف
+
+141
+00:12:23,590 --> 00:12:32,090
+هل الـimmune modulation يعني في استجابة أو لأعنده
+
+142
+00:12:32,090 --> 00:12:36,070
+أيضًا الـ glucagon من الفحصات اللي بيتتم وهذا
+
+143
+00:12:36,070 --> 00:12:41,910
+بيستخدم لل diagnosis of alpha cell tumors
+
+144
+00:12:41,910 --> 00:12:45,350
+pathogenesis
+
+145
+00:12:45,350 --> 00:12:54,020
+of type 1 diabetes mellitus حكينا سابقًا أنهالسبب
+
+146
+00:12:54,020 --> 00:12:59,900
+ليحدوث الـ Type 1 diabetes mellitus ممكن يكون بسبب
+
+147
+00:12:59,900 --> 00:13:03,740
+اللي هو الـ autoimmune destruction of beta cells
+
+148
+00:13:03,740 --> 00:13:11,500
+وطبعاً السبب هذا اللي هو بيمثل يعني الجزء الأكبر
+
+149
+00:13:11,500 --> 00:13:17,380
+من الإصابات بالـ Type 1 وعنا الجزء الآخر اللي هو
+
+150
+00:13:17,380 --> 00:13:20,440
+بيكون السبب غير معروف اللي هو الـ idiopathic
+
+151
+00:13:22,670 --> 00:13:25,270
+الـ in the vast majority of patients destruction
+
+152
+00:13:25,270 --> 00:13:31,910
+is mediated by T cells وهذا النوع اللي هو المسئول
+
+153
+00:13:31,910 --> 00:13:36,890
+عنه الـ autoimmune destruction بنطلق عليه أيضًا
+
+154
+00:13:36,890 --> 00:13:45,470
+type 1a أو immune mediated diabetes الآن الخلايا
+
+155
+00:13:45,470 --> 00:13:51,500
+اللي فعليًا بيهاجمة جهاز المناعة هوخلايا الـ Beta
+
+156
+00:13:51,500 --> 00:13:56,040
+-cells بدون ما يكون فيه أي تأثير على الـ Alpha
+
+157
+00:13:56,040 --> 00:13:59,880
+-cells أو الـ Delta-cells يبقى الـ Alpha و الـ
+
+158
+00:13:59,880 --> 00:14:04,260
+Delta-cells are preserved بتم اللي هو المحافظة
+
+159
+00:14:04,260 --> 00:14:10,040
+عليهم The islet cells have a chronic mononuclear
+
+160
+00:14:10,040 --> 00:14:15,560
+cell infiltrate يبقى بيصير فيه عندناinfiltration
+
+161
+00:14:15,560 --> 00:14:19,800
+اللي هو lymphocytic infiltration لالـ islets of
+
+162
+00:14:19,800 --> 00:14:24,840
+Langerhans وهذه اللي هو بيطلق عليها enceolitis
+
+163
+00:14:24,840 --> 00:14:28,740
+اللي هو inflammation of the islets of Langerhans
+
+164
+00:14:28,740 --> 00:14:32,580
+وزي ما قلنا بيحصل فيها اللي هو lymphocytic
+
+165
+00:14:32,580 --> 00:14:34,180
+infiltration
+
+166
+00:14:36,990 --> 00:14:43,570
+الـ Autoimmune Destruction الـ process اللي هتقدي
+
+167
+00:14:43,570 --> 00:14:46,810
+إلى طبعا Destruction of Beta Cells وبالتالي الـ
+
+168
+00:14:46,810 --> 00:14:52,710
+Type I ده Beta Smaletas المدة اللي هتاخدها بتختلف
+
+169
+00:14:52,710 --> 00:14:58,810
+يعني من month ل years وهذا يعني مرتبط ممكن بأسباب
+
+170
+00:14:58,810 --> 00:15:07,890
+مختلفة ممكن منها عمر الشخص المصابالآن الـ ال
+
+171
+00:15:07,890 --> 00:15:12,410
+clinical presentations فعليًا و ال diagnosis ممكن
+
+172
+00:15:12,410 --> 00:15:18,370
+أو ال symptoms ممكن تظهر لما يصير فيه أن 80 إلى 90
+
+173
+00:15:18,370 --> 00:15:26,650
+بالمية من ال beta cells يعني بالفعل صار ناقص فيها
+
+174
+00:15:29,000 --> 00:15:32,360
+رقم اتفاق الأطفال للتدمير البيتا هي مختلفة وعادة
+
+175
+00:15:32,360 --> 00:15:37,840
+أسرع في الأطفال من الأطفال اللي كمان اللي هو زي ما
+
+176
+00:15:37,840 --> 00:15:42,980
+قلنا العمر بيفرق وعنا ال destruction ل ال beta
+
+177
+00:15:42,980 --> 00:15:51,360
+cells هذي بيكون أسرع عند الأطفال في حالة اللي هو
+
+178
+00:15:51,360 --> 00:15:55,920
+ال autoimmune destruction ل ال beta cellsبيتم
+
+179
+00:15:55,920 --> 00:15:59,680
+إنتاج العديد من الـ antibodies
+
+180
+00:16:02,580 --> 00:16:07,080
+وممكن من خلال الكشف عن هذه الـ Antibodies تتم
+
+181
+00:16:07,080 --> 00:16:14,400
+تأكيد الإصابة بالـ Type 1 Diabetes Mellitus وهذه
+
+182
+00:16:14,400 --> 00:16:19,240
+الـ Antibodies ممكن يصلها Detection في الـ Serum
+
+183
+00:16:19,240 --> 00:16:24,080
+لإيه ال patients years before the onset of
+
+184
+00:16:24,080 --> 00:16:29,520
+hyperglycemia لأن حلولنا ممكن موضوعالـ ال
+
+185
+00:16:29,520 --> 00:16:32,580
+destruction ياخد سنوات وبالتالي هيكون فيها عندنا
+
+186
+00:16:32,580 --> 00:16:37,060
+موجود antibodies لو يعني تم الكشف عن هذه ال
+
+187
+00:16:37,060 --> 00:16:42,220
+antibodies بيه ال patients serumمن الـ Antibodies
+
+188
+00:16:42,220 --> 00:16:47,140
+اللي بتكون موجودة في حالات الـ Type 1 diabetes
+
+189
+00:16:47,140 --> 00:16:51,640
+mellitus فينا القارة Cell Cytoplasmic Antibodies
+
+190
+00:16:51,640 --> 00:17:01,100
+وهذه الـ Antibodies بتنتج ضد أنتجينيسمى سيالو
+
+191
+00:17:01,100 --> 00:17:05,460
+إيجلوكو كونجيجيت أنتيجن وهذا الانتيجن موجود
+
+192
+00:17:05,460 --> 00:17:09,360
+بالـCytoplasm of all endocrine cells of the
+
+193
+00:17:09,360 --> 00:17:14,120
+pancreatic eyelids. These antibodies are detected
+
+194
+00:17:14,120 --> 00:17:17,480
+in the serum of 0.5% of normal subjects، بما يمكن
+
+195
+00:17:17,480 --> 00:17:21,160
+أن الـantibodies هذه كمان اللي جيها عند نسبة قليلة
+
+196
+00:17:21,160 --> 00:17:26,800
+من الأشخاص السالمين، اللي هي تقريبا عن 0.5%of
+
+197
+00:17:26,800 --> 00:17:32,100
+normal subjects لكن أكيد بتكون موجودة بيه عند
+
+198
+00:17:32,100 --> 00:17:34,640
+الأشخاص المصابين بالـ Type 1 diabetes mellitus
+
+199
+00:17:34,640 --> 00:17:40,620
+اللي هو 75% إلى 85% of patients with a newly
+
+200
+00:17:40,620 --> 00:17:43,920
+diagnosed Type 1 diabetes mellitus have eyelid
+
+201
+00:17:43,920 --> 00:17:50,320
+cell cytoplasmic antibodies عندنا
+
+202
+00:17:50,320 --> 00:17:54,890
+antibody آخر برضه ممكن يكون موجودانشلين O2
+
+203
+00:17:54,890 --> 00:18:00,390
+Antibodies وهذا موجود بنسبة عالية من الأطفال
+
+204
+00:18:00,390 --> 00:18:02,530
+المصابين بالـ Type 1 Diabetes Mellitus اللي هو
+
+205
+00:18:02,530 --> 00:18:08,950
+موجود في أكتر من 90% من الأطفال اللي عندهم Type 1
+
+206
+00:18:08,950 --> 00:18:15,830
+Diabetes Mellitus يا بالسن الخامسة لكن نسبة الـ
+
+207
+00:18:15,830 --> 00:18:21,170
+Antibodies هذه بتقل له بعد سن الخامسة
+
+208
+00:18:23,340 --> 00:18:28,700
+يبقى الحالات اللي فوق سن الـ 12 بتلاقي أنه هذه الـ
+
+209
+00:18:28,700 --> 00:18:34,140
+Antibodies موجودة بيه اللي هو تقريبا عند 40% أو
+
+210
+00:18:34,140 --> 00:18:40,120
+أقل من هدول الأشخاص الـ Antibodies هذه برضه ممكن
+
+211
+00:18:40,120 --> 00:18:43,220
+تصل إلى detection عند الأشخاص السالمين برضه
+
+212
+00:18:43,220 --> 00:18:50,260
+بالنسبة قليلة لـ 0.5%ممكن أيضًا تتم الكشف عن
+
+213
+00:18:50,260 --> 00:18:56,800
+antibodies لـ 65-kD-isoform of glutamic acid D
+
+214
+00:18:56,800 --> 00:19:00,040
+-carboxylase الوالجاد 65
+
+215
+00:19:02,470 --> 00:19:06,110
+واحنا قلنا إنه ممكن يتم الكشف عن الـ Antibodies
+
+216
+00:19:06,110 --> 00:19:11,710
+اللي هو السنوات قبل ما فعلياً يتم عملية الـ
+
+217
+00:19:11,710 --> 00:19:15,710
+diagnosis لشخص with type 1 diabetes مليتاس وعنا
+
+218
+00:19:15,710 --> 00:19:22,790
+تقريباً ممكن يتم الكشف عن أو ال detection للـ
+
+219
+00:19:22,790 --> 00:19:25,090
+antibodies اللي هو against glutamic acid
+
+220
+00:19:25,090 --> 00:19:28,750
+decarboxylase 10 years before the onset of a
+
+221
+00:19:28,750 --> 00:19:33,020
+clinical type 1 diabetesمالليتاس وهذه الـ
+
+222
+00:19:33,020 --> 00:19:37,980
+antibodies موجودة عن 60% من ال patients within you
+
+223
+00:19:37,980 --> 00:19:44,280
+اللي diagnosed type 1 diabetes مالليتاس في أن بعض
+
+224
+00:19:44,280 --> 00:19:49,160
+الحالات اللي ممكن يعني تشخص بداية على إنها type 2
+
+225
+00:19:49,160 --> 00:19:50,360
+diabetes مالليتاس
+
+226
+00:19:53,000 --> 00:19:56,220
+اللي هو apparently يعني type 2 diabetes mellitus
+
+227
+00:19:56,220 --> 00:20:05,920
+لكن إذا تم اللي هو الفحص الجاد 65 antibodies وطبعا
+
+228
+00:20:05,920 --> 00:20:11,080
+تم الكشف عن هذه ال antibodies عند هذا اللي هو ال
+
+229
+00:20:11,080 --> 00:20:15,620
+patient إيه بمعناته ال diagnosis الصحيح هيكون اللي
+
+230
+00:20:15,620 --> 00:20:17,220
+هو type 1 diabetes
+
+231
+00:20:24,180 --> 00:20:31,160
+اللي زي ما قلنا لو يعني بعد فترة من الزمن هلاجي
+
+232
+00:20:31,160 --> 00:20:36,680
+أنه هذا الشخص فعليا اللي هو عنده type 1 diabetes
+
+233
+00:20:36,680 --> 00:20:45,610
+mellitus ومش type 2ذكرنا سابقاً إنه الـtype 2
+
+234
+00:20:45,610 --> 00:20:48,670
+diabetes mellitus patients يعني ممكن في مراحل
+
+235
+00:20:48,670 --> 00:20:54,490
+متقدمة يعني بيصبحوا يعتمدوا على الـexogenous
+
+236
+00:20:54,490 --> 00:20:59,990
+انسلين لكن في بعض الحالات اللي هو الـtype 2
+
+237
+00:20:59,990 --> 00:21:06,430
+diabetes mellitusممكن الـ progression لـ الـ
+
+238
+00:21:06,430 --> 00:21:13,450
+disease تكون سريعة يعني ومايحتاجوش مدة طويلة عشان
+
+239
+00:21:13,450 --> 00:21:19,070
+اللي هو يحتاجوا إلى exogenous insulin الآن ممكن
+
+240
+00:21:19,070 --> 00:21:23,450
+نكشف عن هدول الفئة من المرضى اللي هو عندهم type 2
+
+241
+00:21:23,450 --> 00:21:30,410
+diabetes mellitusلكن ممكن يعني يصير اللي هو
+
+242
+00:21:30,410 --> 00:21:36,610
+deficiency للإنسلين مستقبلا من خلال فحصنا للـ
+
+243
+00:21:36,610 --> 00:21:41,410
+GAD65 Antibodies يبقى الـType-2 Diabetes مليتها ال
+
+244
+00:21:41,410 --> 00:21:45,010
+patients اللي بنكشف عن وجود اللي هو الـ GAD65
+
+245
+00:21:45,010 --> 00:21:48,230
+Antibodies عندهم يبقى هدول ممكن يصير في عنا
+
+246
+00:21:48,230 --> 00:21:53,590
+progression بشكل سريع
+
+247
+00:21:54,610 --> 00:22:01,010
+ويتحولوا إلى طبعا الاعتماد على الانسلين بشكل كامل
+
+248
+00:22:01,010 --> 00:22:06,510
+عندنا أيضا Antibodies اللي بيفرزوا against
+
+249
+00:22:06,510 --> 00:22:12,410
+insulinoma associated antigens اللي IA to A و IA
+
+250
+00:22:12,410 --> 00:22:18,250
+to Beta A هدول الانتيجين هم عبارة عن Transmembrane
+
+251
+00:22:18,250 --> 00:22:23,030
+proteins of dead core vesicles
+
+252
+00:22:25,360 --> 00:22:32,060
+الآن لما بيصير فينا مهاجمة لهذه الـ antigens من
+
+253
+00:22:32,060 --> 00:22:38,660
+خلال ال antibodies اللي بتتكون ضدهم هذا بيؤدي إلى
+
+254
+00:22:39,840 --> 00:22:45,560
+تقليل عدد اللي هو الـ dense core vesicles اللي هي
+
+255
+00:22:45,560 --> 00:22:50,300
+اللي بتحتوي على هرمونات وبهذه الحالة مازال بنحكي
+
+256
+00:22:50,300 --> 00:22:54,540
+على الـ islands of Langerhans وبنحكي على هرمونات
+
+257
+00:22:54,540 --> 00:23:00,040
+زي اللي هو الانسولين في الـ beta cells يعني الـ
+
+258
+00:23:00,040 --> 00:23:04,600
+antibodies اللي بتفرز ضد هذه الـ antigens بتقلل من
+
+259
+00:23:04,600 --> 00:23:10,980
+الـ dense core vesiclesوبالتالي بتقلل من ال
+
+260
+00:23:10,980 --> 00:23:17,640
+secretion of insulin hormones هذه ال antibodies
+
+261
+00:23:17,640 --> 00:23:21,140
+have been detected in more than 50% of newly
+
+262
+00:23:21,140 --> 00:23:26,980
+diagnosed type 1 diabetes mellitus patients عندنا
+
+263
+00:23:26,980 --> 00:23:32,680
+أيضا antibodies أخرى اللي هي بتنتج against the
+
+264
+00:23:32,680 --> 00:23:38,580
+zinc transporterاللي عبارة عن Transmembrane، a
+
+265
+00:23:38,580 --> 00:23:44,420
+protein responsible for the influx of zinc and
+
+266
+00:23:44,420 --> 00:23:51,300
+other ions Was
+
+267
+00:23:51,300 --> 00:23:55,840
+identified in 2007 as a major auto-antigen in type
+
+268
+00:23:55,840 --> 00:23:57,880
+1 diabetes mellitus
+
+269
+00:24:00,080 --> 00:24:05,160
+الأقل مميزًا من الانتباطات الـ O2 في الديابتس يعني
+
+270
+00:24:05,160 --> 00:24:10,380
+بيحتاج إلى ممكن أكتر عملية تحقيقها بشكل مفهوم
+
+271
+00:24:13,810 --> 00:24:19,890
+60% من الحالات اللي بتتم اكتشافها من اللي هو الـ
+
+272
+00:24:19,890 --> 00:24:26,770
+Type 1 diabetes mellitus بنلاقي أنه فيه اللي هو
+
+273
+00:24:26,770 --> 00:24:33,970
+antibodies ضد الـ Zinc الـ Transporterطبعاً مقارنة
+
+274
+00:24:33,970 --> 00:24:39,950
+بأقل من 2% عند الـ Controls أو اللي هو 3% عند
+
+275
+00:24:39,950 --> 00:24:43,950
+الأشخاص المصابين بالـ Type 2 Diabetes Mellitus
+
+276
+00:24:43,950 --> 00:24:49,890
+بنسبة عالية اللي هو 60 إلى 80% من ال patients with
+
+277
+00:24:49,890 --> 00:24:55,070
+Type 1 Diabetes Mellitus بنلاقي اللي هو عندهم هذا
+
+278
+00:24:55,070 --> 00:25:01,080
+الـ Auto Antigenأكثر مهمات الانتيبادات لـ Zinc
+
+279
+00:25:01,080 --> 00:25:06,740
+Transporter تتم إتجارها في حوالي 26% من المستخدمين
+
+280
+00:25:06,740 --> 00:25:09,460
+لـ Type 1 Diabetes Mellitus اللي هم نقاط مفارقة
+
+281
+00:25:09,460 --> 00:25:14,300
+لعائلة أخرى أوتو انتيبادات الانتيبادات اللي
+
+282
+00:25:14,300 --> 00:25:20,200
+ذكرناها سابقا ممكن نلاقي أن شخص عنده Type 1
+
+283
+00:25:20,200 --> 00:25:24,450
+Diabetes Mellitusو negative لل auto antibodies
+
+284
+00:25:24,450 --> 00:25:30,910
+الأخرى كلها لكن يكون positive للوزينك transporter
+
+285
+00:25:30,910 --> 00:25:32,270
+antibodies
+
+286
+00:25:36,200 --> 00:25:41,300
+طبعًا ممكن نكشف عن هذه الـ Antibodies المختلفة
+
+287
+00:25:41,300 --> 00:25:45,940
+باستخدام الـ Radio Immunoassay باستخدام الـ ELISA
+
+288
+00:25:45,940 --> 00:25:51,280
+وفي إن له تكنيك جديد يسمى Plasmonic Chip Based
+
+289
+00:25:51,280 --> 00:25:56,980
+Assay برضه ممكن يستخدم للكشف عن الـ Antibodies
+
+290
+00:25:56,980 --> 00:25:58,620
+المختلفة
+
+291
+00:26:00,600 --> 00:26:04,400
+بما يتعلق بالـ Genetics و الـ Type 1 diabetes
+
+292
+00:26:04,400 --> 00:26:12,220
+mellitus الـ Genetics يعني ابتلاعب ممكن دور أقل بـ
+
+293
+00:26:12,220 --> 00:26:17,580
+الـ Type 1 diabetes mellitus إذا ما تم مقالة الأمر
+
+294
+00:26:17,580 --> 00:26:20,320
+بـ الـ Type 2 diabetes mellitus
+
+295
+00:26:22,350 --> 00:26:24,850
+الـ susceptibility to type 1 diabetes mellitus is
+
+296
+00:26:24,850 --> 00:26:27,390
+inherited but the mode of inheritance is complex
+
+297
+00:26:27,390 --> 00:26:31,730
+and has not been identified، يعني لسه بنحتاج more
+
+298
+00:26:31,730 --> 00:26:37,010
+research عشان نفهم أكتر علاقة ال genetics بالـ
+
+299
+00:26:37,010 --> 00:26:40,890
+type 1 diabetes mellitus، it is a multi-genetic
+
+300
+00:26:40,890 --> 00:26:46,170
+trait، يعني أن أكتر من جين اللي هم علاقة بتكون
+
+301
+00:26:46,720 --> 00:26:50,940
+البرط And the major locus is the major
+
+302
+00:26:50,940 --> 00:26:56,740
+histocompatibility complex on chromosome 6 إن
+
+303
+00:26:56,740 --> 00:27:05,700
+أيضًا 11 موقع آخر على 9 كروموزومات برضه بيلعب دور
+
+304
+00:27:05,700 --> 00:27:16,510
+ويعني مرتبط بالـ regulatory region للإنسلين جينالـ
+
+305
+00:27:16,510 --> 00:27:16,750
+Human Leukocyte Antigen HLA-DQ-DR الهيومان
+
+306
+00:27:16,750 --> 00:27:22,050
+ليكوسايت انتيجين HLA-DQ-DR الهيومان ليكوسايت
+
+307
+00:27:22,050 --> 00:27:22,070
+-DR الهيومان ليكوسايت انتيجين HLA-DQ-DR الهيومان
+
+308
+00:27:22,070 --> 00:27:22,950
+ليكوسايت انتيجين HLA-DQ-DR الهيومان ليكوسايت
+
+309
+00:27:22,950 --> 00:27:27,310
+انتيجين HLA-DQ-DR الهيومان ليكوسايت انتيجين HLA-DQ
+
+310
+00:27:27,310 --> 00:27:34,870
+-DR الهيومان ليكوسايت انتيجين HLA-DQ-DR الهيومان
+
+311
+00:27:34,870 --> 00:27:39,430
+ليكوسايت انتيجين HLA-DQ-DR الهيومان ليكوسايت
+
+312
+00:27:39,430 --> 00:27:45,160
+انتيجين HLA-DQبما يتعلق بالـ Concordance Rate بين
+
+313
+00:27:45,160 --> 00:27:53,840
+Identical Twins اللي هو تقريبًا 30% فقط يعني عند
+
+314
+00:27:53,840 --> 00:27:59,640
+الـ Identical Twins ممكن إذا عند 30% من الأشخاص
+
+315
+00:27:59,640 --> 00:28:02,240
+اللي هو Identical Twins إذا واحد عنده Type 1
+
+316
+00:28:02,240 --> 00:28:07,240
+Diabetes الآخر هيكون أو هيصاب بـType 1 Diabetes
+
+317
+00:28:07,240 --> 00:28:08,220
+Malatus
+
+318
+00:28:11,080 --> 00:28:15,340
+10 بالمية of patients with type 1 diabetes
+
+319
+00:28:15,340 --> 00:28:19,360
+mellitus have an affected first degree relative
+
+320
+00:28:19,360 --> 00:28:27,520
+وعنا برضه مواقع أخرى اللي غير الـ HLA اللي هو
+
+321
+00:28:27,520 --> 00:28:32,320
+تقريباً 40 جين
+
+322
+00:28:32,320 --> 00:28:39,440
+هدول برضه لجوا إن فيه لهمعلاقة لكن these have a
+
+323
+00:28:39,440 --> 00:28:44,800
+smaller effects التأثير يعني أقل إذا ما كورن
+
+324
+00:28:44,800 --> 00:28:48,220
+بالتأثير ل ال HLA
+
+325
+00:28:50,900 --> 00:28:56,700
+يعني زي ما شفنا إنه في عندنا ممكن يعني Genes
+
+326
+00:28:56,700 --> 00:29:01,820
+مختلفة وعديدة اللي بتلعب دور ممكن بالإصابة بـType
+
+327
+00:29:01,820 --> 00:29:08,560
+I Diabetes Mellitus وهذا برشح إنه Genات أكتر ممكن
+
+328
+00:29:08,560 --> 00:29:14,320
+يتم التعرف عليها مستقبلاً وبرضه يربطوها بـType I
+
+329
+00:29:14,320 --> 00:29:21,030
+Diabetes Mellitusبما يتعلق بالـ Measurement أو الـ
+
+330
+00:29:21,030 --> 00:29:26,810
+Detection of Genetic Markers هل مفيدة بالمرحلة
+
+331
+00:29:26,810 --> 00:29:30,630
+الحالية الـ Routine Measurement of Genetic Markers
+
+332
+00:29:30,630 --> 00:29:35,490
+is not of value at this time for the diagnosis or
+
+333
+00:29:35,490 --> 00:29:38,850
+management of patients with type 1 diabetes
+
+334
+00:29:38,850 --> 00:29:43,360
+mellitusولا يعني لأ إلها فائدة في الـ diagnosis
+
+335
+00:29:43,360 --> 00:29:50,300
+ولا إلها فائدة أيضًا في الـ management أو في إدارة
+
+336
+00:29:50,300 --> 00:29:56,620
+المرضى من ناحية أخرى ال environment برضه والعوامل
+
+337
+00:29:56,620 --> 00:30:02,500
+البيئية طبعًا مع وجود اللي هو الـ genetic
+
+338
+00:30:02,500 --> 00:30:06,820
+predisposition العوامل البيئية برضه بتلعب دور في
+
+339
+00:30:06,820 --> 00:30:13,440
+الإصابةمقالات يبقى تسمح بأن مصادر البيئة مهتمين
+
+340
+00:30:13,440 --> 00:30:18,680
+بالتقديم للديابتسومن هذه الـ Environmental Factors
+
+341
+00:30:18,680 --> 00:30:23,860
+في عندنا Viruses في عندنا اللي ممكن بعض ال
+
+342
+00:30:23,860 --> 00:30:30,940
+Chemicals ممكن ال .. ال .. ال food يعني العوامل
+
+343
+00:30:30,940 --> 00:30:34,960
+المختلفة هذه ممكن تلعب دور ال viruses زي اللي
+
+344
+00:30:34,960 --> 00:30:39,600
+روبيلا .. روبيلا مامس Indirovirus كوكساكي virus
+
+345
+00:30:39,600 --> 00:30:42,600
+بيه have been implicated
+
+346
+00:30:45,160 --> 00:30:54,040
+والإصابة ببعض الفيروسات مرتبط بوجود شبه بين Viral
+
+347
+00:30:54,040 --> 00:31:02,180
+Protein مع Beta Cell Protein يبقى الـ Viral
+
+348
+00:31:02,180 --> 00:31:05,180
+Protein shares amino acid sequence with a Beta
+
+349
+00:31:05,180 --> 00:31:10,280
+Cell Protein لما يوم بتاع الإصابة في هذه الفيروسات
+
+350
+00:31:10,280 --> 00:31:12,320
+ممكن يعني
+
+351
+00:31:15,000 --> 00:31:19,280
+يفعل أو can initiate اللي هو immune response
+
+352
+00:31:19,280 --> 00:31:25,430
+against the beta cellsزي ما قلنا إنه الـ Genetic
+
+353
+00:31:25,430 --> 00:31:30,310
+Factors وجود الـ Genetic Factors بتخلي الشخص يعني
+
+354
+00:31:30,310 --> 00:31:35,990
+more susceptible زي اللي هو الـ HLA-type عند
+
+355
+00:31:35,990 --> 00:31:40,770
+المريض وبالتالي بتحدد يعني الـ Genetic Factors مع
+
+356
+00:31:40,770 --> 00:31:43,770
+وجود له الـ Environmental Factors determine the
+
+357
+00:31:43,770 --> 00:31:49,390
+progression of the Beta Cell destructionأيضًا زي
+
+358
+00:31:49,390 --> 00:31:53,290
+ما قلنا إنه ممكن بعض الأطعمة أو ممكن تلعب دور
+
+359
+00:31:53,290 --> 00:31:56,770
+وخاصة عند الأطفال يعني في عندنا من خلال الـ
+
+360
+00:31:56,770 --> 00:32:01,970
+Epidemiological studies they have implicated early
+
+361
+00:32:01,970 --> 00:32:05,470
+exposure to cow's milk as a trigger of type 1
+
+362
+00:32:05,470 --> 00:32:10,950
+diabetes mellitus يبقى الأطفال إذا كان بيتم
+
+363
+00:32:10,950 --> 00:32:16,990
+إعطائهم الوردع واللي هو يعني قبل ما يصل هذا الطفل
+
+364
+00:32:16,990 --> 00:32:26,400
+عمره السنةإذا كان بيتم إعطائهم حليب بقر لجوا إنه
+
+365
+00:32:26,400 --> 00:32:30,300
+هدول الأطفال ممكن يصابوا مستقبلا بـ Type 1
+
+366
+00:32:30,300 --> 00:32:34,780
+diabetes mellitus طبعا الأطفال اللي عندهم يعني
+
+367
+00:32:34,780 --> 00:32:40,440
+بتكون لسه مش fully mature وبالتالي ممكن يصير في
+
+368
+00:32:40,440 --> 00:32:46,810
+عنا absorption لبعضممكن المكونات اللي المفروض ما
+
+369
+00:32:46,810 --> 00:32:50,350
+يمثلهاش absorption وبتالي ممكن هذي يتشكل اللي هو
+
+370
+00:32:50,350 --> 00:32:55,430
+ال trigger للإصابة بيقل type 1 diabetes mellitus
+
+371
+00:32:55,430 --> 00:33:00,270
+this model is argumentative and has been debated
+
+372
+00:33:00,270 --> 00:33:06,710
+for decades بيبقى لسه فيش فعليا يعني إجماع على
+
+373
+00:33:06,710 --> 00:33:13,370
+اللي هو فكرة اللي هو ال cows milk وفييعني خلاف
+
+374
+00:33:13,370 --> 00:33:20,990
+وجدال كبير بما يتعلق بهذا الأمر طيب
+
+375
+00:33:20,990 --> 00:33:23,670
+بما يتعلق بالـ pathogenesis of type 2 diabetes
+
+376
+00:33:23,670 --> 00:33:32,860
+mellitus في عندنا مشكلتين اللي هو أساسيتينالمشكلة
+
+377
+00:33:32,860 --> 00:33:36,940
+الأولى هي الـ Insulin resistance اللي هو عدم
+
+378
+00:33:36,940 --> 00:33:41,580
+استجابة الخلايا للإنسلين بالشكل المطلوب Decreased
+
+379
+00:33:41,580 --> 00:33:46,560
+ability of insulin to act on peripheral tissue It
+
+380
+00:33:46,560 --> 00:33:49,300
+is thought by many to be the primary underlying
+
+381
+00:33:49,300 --> 00:33:55,200
+pathological process وهي هذه المشكلة الأساسية
+
+382
+00:33:56,680 --> 00:34:01,100
+والمشكلة التانية Beta cell dysfunction in ability
+
+383
+00:34:01,100 --> 00:34:04,660
+of the pancreas to produce sufficient insulin to
+
+384
+00:34:04,660 --> 00:34:09,440
+compensate for the insulin resistance بعدم مقدرة
+
+385
+00:34:09,440 --> 00:34:13,980
+البنكرياز على التعامل مع المشكلة القائمة اللي هي
+
+386
+00:34:13,980 --> 00:34:17,780
+يقولنا المشكلة الأساسية وهيالـ Insulin resistance
+
+387
+00:34:17,780 --> 00:34:23,320
+و اللي هو الزيادة في ال secretion للإنسلين عشان
+
+388
+00:34:23,320 --> 00:34:30,160
+انعود ال insulin resistance اللي صار.يبقى المريض
+
+389
+00:34:30,160 --> 00:34:38,880
+بداية بيبدأ ب relative deficiency of insulinتمام،
+
+390
+00:34:38,880 --> 00:34:42,180
+لأنه زي ما قلنا بيبدأ يصير في عنا Beta cell
+
+391
+00:34:42,180 --> 00:34:47,080
+dysfunction وفي الحالات المتقدمة من الـ Type 2
+
+392
+00:34:47,080 --> 00:34:50,840
+diabetes mellitus ممكن اللي هو ينتهي الشخص بـ
+
+393
+00:34:50,840 --> 00:34:55,600
+Absolute deficiency ويصير اللي هو بيعتمد على
+
+394
+00:34:55,600 --> 00:34:59,600
+الإنسلين كعلاج بشكل أساسي
+
+395
+00:35:02,050 --> 00:35:07,070
+فيه hand في هذه اللي هو النقطة جدال اللي هو الـ
+
+396
+00:35:07,070 --> 00:35:10,250
+whether type 2 is due primarily to a defect in
+
+397
+00:35:10,250 --> 00:35:15,290
+beta cell secretion or to peripheral resistance to
+
+398
+00:35:15,290 --> 00:35:21,870
+insulin or to both دايماً كان فيه خلاف إنه إيش
+
+399
+00:35:21,870 --> 00:35:25,850
+الأول؟هل الـ Insulin Resistance هي المشكلة الأولى
+
+400
+00:35:25,850 --> 00:35:29,790
+و اللي بينتج عنها Beta Cell Dysfunction ولا
+
+401
+00:35:29,790 --> 00:35:34,690
+المشكلة الأساسية هي الـ Beta Cell Dysfunction
+
+402
+00:35:34,690 --> 00:35:39,450
+وبالتالي الـ Secretion للإنسلين؟
+
+403
+00:35:42,920 --> 00:35:46,800
+البيانات متوفرة لتدعم المصطلح أن مقاومة الإنسانية
+
+404
+00:35:46,800 --> 00:35:52,040
+مخطط أساسي من خلال المعلومات اللي بقتت متوفرة من
+
+405
+00:35:52,040 --> 00:35:59,080
+خلال طبعا الـ research اللي تم بشكل كبير عندنا ال
+
+406
+00:35:59,080 --> 00:36:04,800
+data بتدعم أن المشكلة الأساسية هي الـ insulin
+
+407
+00:36:04,800 --> 00:36:06,840
+resistance
+
+408
+00:36:09,250 --> 00:36:13,930
+والبعد هيك ممكن يصير في عنا مشكلة بالانسولين
+
+409
+00:36:14,380 --> 00:36:17,440
+secretion، يعني المشكلة الأساسية Insulin
+
+410
+00:36:17,440 --> 00:36:23,420
+resistance واللي ممكن تكون موجودة يعني من فترة
+
+411
+00:36:23,420 --> 00:36:29,340
+طويلة عند المريض واللي بتكون طبعا فيه تزايد لغاية
+
+412
+00:36:29,340 --> 00:36:37,000
+ما فعليا يصير فيه diagnosis للمريض بـ Type 2
+
+413
+00:36:37,000 --> 00:36:40,280
+diabetesمالليتس يبقى ال insulin resistance ممكن
+
+414
+00:36:40,280 --> 00:36:47,560
+تكون موجودة يعني و اتزيد عند المرضى من اللي هو
+
+415
+00:36:47,560 --> 00:36:53,660
+النوع التاني لالـ diabetes طيب ايش سبب ال insulin
+
+416
+00:36:53,660 --> 00:36:56,360
+resistance لان احنا اتفقنا ان المشكلة الأساسية ال
+
+417
+00:36:56,360 --> 00:37:02,230
+insulin resistance الآن في أن genetic factorsتمام
+
+418
+00:37:02,230 --> 00:37:08,510
+يبقى هذه predispose the persons to type 2 diabetes
+
+419
+00:37:08,510 --> 00:37:14,050
+mellitus والآن بيظل أن الشخص هذا يتعرض لل
+
+420
+00:37:14,050 --> 00:37:16,930
+environmental factors يبقى إذا كان ال genetic
+
+421
+00:37:16,930 --> 00:37:21,550
+factors موجودة ال environmental factors الآن
+
+422
+00:37:24,260 --> 00:37:28,800
+تؤدي إلى إصابة أو تعرض الشخص للـ Environmental
+
+423
+00:37:28,800 --> 00:37:34,420
+Factors اللي هنذكرها هتخلي الشخص يصاب بالـ Type 2
+
+424
+00:37:34,420 --> 00:37:39,380
+Diabetes Mellitus يبقى
+
+425
+00:37:39,380 --> 00:37:43,440
+زي ما اتفقنا أن المشكلة الأساسية هي الـ Insulin
+
+426
+00:37:43,440 --> 00:37:44,740
+Resistance
+
+427
+00:37:46,580 --> 00:37:50,100
+والـ الادب بيحاول اللي هو البنك الرياضي انه يصير
+
+428
+00:37:50,100 --> 00:37:56,420
+فيه انها compensation ويصير فيه الوزيادة بيه ال ..
+
+429
+00:37:56,420 --> 00:38:01,980
+يعني الطلب على ال beta cells عشان يتعود ال ..
+
+430
+00:38:01,980 --> 00:38:08,600
+المشكلة اللي صارت بالإنسلين يبقى هذا بيؤدي إلى
+
+431
+00:38:08,600 --> 00:38:13,840
+progressive loss of beta cell functionالتي محتاجة
+
+432
+00:38:13,840 --> 00:38:19,680
+للتطور من الهيبرغلسيميا الانسولينية المقاومة مع
+
+433
+00:38:19,680 --> 00:38:25,140
+اختلاف بيطاسيل مستمر هذا بيؤدي إلى حدوث ارتفاع في
+
+434
+00:38:25,140 --> 00:38:31,460
+الجلوكوز الاختلاف الرئيسي هو اختلاف جلوكوز اندوست
+
+435
+00:38:31,460 --> 00:38:37,440
+انسولينية التي تسمى كالترتيب الجلوكوز غير مجتمع
+
+436
+00:38:37,440 --> 00:38:44,780
+يبقى لما الشخص بيكون طبيعيلمّا بيرتفع لنا الـ
+
+437
+00:38:44,780 --> 00:38:51,020
+glucose هذا بيعمل اللي هو simulation لل beta cells
+
+438
+00:38:51,020 --> 00:38:57,490
+وبيزيد لنا إفراز ال insulinلكن المشكلة هان في
+
+439
+00:38:57,490 --> 00:38:59,870
+الناس اللي عندهم اللي وضعتها بتوع ضيبة Smellitus
+
+440
+00:38:59,870 --> 00:39:05,510
+إنه بيبطل الـ Glucose يعمل اللي هو induction
+
+441
+00:39:05,510 --> 00:39:12,390
+بالشكل الصحيح للإنسلين الريليز وبالتالي بيصير إنه
+
+442
+00:39:12,390 --> 00:39:16,530
+ما يعرف بـ Selective Glucose Unresponsiveness
+
+443
+00:39:18,310 --> 00:39:22,630
+يبقى سبب هذه المشكلة هو الارتفاع المستمر في
+
+444
+00:39:22,630 --> 00:39:28,290
+الجلوكوز يبقى عندنا hyperiglycemia appeared to
+
+445
+00:39:28,290 --> 00:39:32,690
+render the beta cells increasingly unresponsive to
+
+446
+00:39:32,690 --> 00:39:38,350
+glucose يبقى الارتفاع المستمر فيهالجلوكوز تمام
+
+447
+00:39:38,350 --> 00:39:43,710
+بيزيد من اللي هو عدم استجابة خلايا الـ Beta cells
+
+448
+00:39:43,710 --> 00:39:49,830
+للارتفاع وهذا ما يسمى بالـGlucotoxicity
+
+449
+00:39:49,830 --> 00:39:53,530
+The degree of dysfunction correlates with both
+
+450
+00:39:53,530 --> 00:39:57,500
+glucose concentrationand a duration of
+
+451
+00:39:57,500 --> 00:40:02,520
+hyperoglycemia هو كل ما زاد ارتفاع ال glucose كل
+
+452
+00:40:02,520 --> 00:40:09,500
+ما طولت مدة ال hyperoglycemia طبعا كل ما زادت
+
+453
+00:40:09,500 --> 00:40:18,040
+عندنا ال glucotoxicity وبالتالي اللي هو ال ال
+
+454
+00:40:18,040 --> 00:40:23,970
+progressive loss of beta cell functionمن ناحية
+
+455
+00:40:23,970 --> 00:40:28,630
+تانية، عندنا أيضًا الزيادة بالـ Free fatty acids
+
+456
+00:40:28,630 --> 00:40:34,510
+يبقى برضه هذه بتلعب دور في الـ Beta cell failure
+
+457
+00:40:34,510 --> 00:40:41,130
+وهذا ما يُعرف بالـ Lipotoxicity عندنا أيضًا
+
+458
+00:40:41,130 --> 00:40:46,430
+المشكلة اللي ذكرناها سابقًا اللي هو الـ disruption
+
+459
+00:40:46,430 --> 00:40:51,580
+of the normal pulsatile releaseوانسلين هذا ذكرنا
+
+460
+00:40:51,580 --> 00:40:54,380
+سابقا ان الناس اللي عندهم type 2 diabetes mellitus
+
+461
+00:40:54,380 --> 00:40:59,020
+اللي هو بيفقدوا ال normal pulsatile release of
+
+462
+00:40:59,020 --> 00:41:05,880
+انسلين and an increase ratio of plasma pro insulin
+
+463
+00:41:05,880 --> 00:41:12,340
+to insulinأيضًا الـ Insulin Resistance برضه زي ما
+
+464
+00:41:12,340 --> 00:41:20,140
+قلنا بيصير يعني جهد كبير على الـ Beta Cells وهذا
+
+465
+00:41:20,140 --> 00:41:28,600
+برضه بيؤدي إلى النقص في الـ Beta Cells عند الأشخاص
+
+466
+00:41:28,600 --> 00:41:35,120
+المصابين بالـ Type 2 Diabetes Mellitus النقطة
+
+467
+00:41:35,120 --> 00:41:39,010
+التانية الـ Insulin Resistancedefined as decreased
+
+468
+00:41:39,010 --> 00:41:44,050
+biological response to normal concentrations of
+
+469
+00:41:44,050 --> 00:41:48,350
+circulating insulin بيبطل فيه أنه اللي هي
+
+470
+00:41:48,350 --> 00:41:50,890
+الاستجابة الطبيعية
+
+471
+00:41:55,010 --> 00:42:00,370
+من قبل الخلايا لـ ال .. اللي هي الـ concentration
+
+472
+00:42:00,370 --> 00:42:03,650
+الطبيعية من الـ insulin يبقى الـ concentration
+
+473
+00:42:03,650 --> 00:42:09,310
+الطبيعية من الـ insulin بتبطل كافية للتعامل مع الـ
+
+474
+00:42:09,310 --> 00:42:12,970
+glucose اللي موجود بالدم طبعا الـ insulin
+
+475
+00:42:12,970 --> 00:42:17,750
+resistance موجودة في اللي هو حالات مختلفة يعني إن
+
+476
+00:42:17,750 --> 00:42:26,180
+في ال obese persons non-diabetic individualsand in
+
+477
+00:42:26,180 --> 00:42:32,900
+patients with type 2 diabetes mellitus طيب
+
+478
+00:42:32,900 --> 00:42:37,780
+الآن المشكلة و ال pathophysiologic defect يعني مش
+
+479
+00:42:37,780 --> 00:42:45,460
+.. ما تمش .. ما تمش تعرف عليه بشكل كامل لكن ال
+
+480
+00:42:45,460 --> 00:42:47,860
+insulin resistance مشكلة ال insulin resistance
+
+481
+00:42:47,860 --> 00:42:52,380
+usually attributed to a defect in insulin action
+
+482
+00:42:52,380 --> 00:42:57,750
+يبقى في عملالانسولين، measurement of insulin
+
+483
+00:42:57,750 --> 00:43:01,110
+resistance in a routine clinical setting is
+
+484
+00:43:01,110 --> 00:43:05,290
+difficultوأختيارات الـ Surrogate، بمعنى الـ
+
+485
+00:43:05,290 --> 00:43:08,950
+Concentration of Fasting Insulin أو الـ U-Glycemic
+
+486
+00:43:08,950 --> 00:43:14,910
+Insulin Clamp تستخدم لإعادة تجارب انسلين غير
+
+487
+00:43:14,910 --> 00:43:18,310
+مباشرة يبقى موضوع انه انقيز الانسلين resistance
+
+488
+00:43:18,310 --> 00:43:23,710
+يعني موضوع صعب اللي هو ننقيزه بطريقة مباشرة لكن
+
+489
+00:43:23,710 --> 00:43:27,950
+ممكن انقيز الانسلين resistance بطريقة غير مباشرة
+
+490
+00:43:27,950 --> 00:43:32,770
+زي ما ذكرنا سابقاممكن من خلال ال fasting اللي هو
+
+491
+00:43:32,770 --> 00:43:36,010
+انسولين مع ال fasting الجلوكوز ممكن نحسب اللي هو
+
+492
+00:43:36,010 --> 00:43:41,550
+IR تماما اللي بتعبر عن ال insulin resistance
+
+493
+00:43:43,840 --> 00:43:48,740
+اللي هم IR ليه اختصار لـ Homostatic Model
+
+494
+00:43:48,740 --> 00:43:54,560
+Assessment of Insulin Resistance من خلاله ممكن
+
+495
+00:43:54,560 --> 00:43:57,700
+نشوف
+
+496
+00:43:57,700 --> 00:44:01,540
+إذا كان الشخص عنده Insulin Resistance أو لا، هنا
+
+497
+00:44:01,540 --> 00:44:08,150
+أيضًا طريقة أخرى الـ Euglycemic Insulin Clampوها
+
+498
+00:44:08,150 --> 00:44:13,650
+دي يعني more invasive وبتحتاج اللي هو وقت أطول
+
+499
+00:44:13,650 --> 00:44:17,210
+ليعني عملها
+
+500
+00:44:20,560 --> 00:44:23,320
+الـ Euglycemic clamp performed in the hospital
+
+501
+00:44:23,320 --> 00:44:28,720
+under closed supervision و لازم بيه المستشفى و
+
+502
+00:44:28,720 --> 00:44:37,120
+الشخص طبعا intravenously بيعطى infusion of insulin
+
+503
+00:44:37,120 --> 00:44:40,680
+constant intravenous infusion of insulin بيعطى
+
+504
+00:44:40,680 --> 00:44:50,090
+اللي هو كمية ثابتة من الانسلينمع إعطاءه لكميات أو
+
+505
+00:44:50,090 --> 00:44:54,590
+variable amounts of glucose يبقى بإيد بيصير فيه
+
+506
+00:44:54,590 --> 00:44:59,010
+إنه constant infusion لإنسلين وبالإيد التاني بنبدأ
+
+507
+00:44:59,010 --> 00:45:07,730
+نعطيه اللي هو كميات اللي هو من ال glucose to
+
+508
+00:45:07,730 --> 00:45:10,250
+maintain blood glucose at a normal fasting
+
+509
+00:45:10,250 --> 00:45:13,940
+concentrationلأن زي ما احنا عارفين ما زال يعطينا
+
+510
+00:45:13,940 --> 00:45:17,220
+انسلين بجه يبدأ الـ glucose بالتناقص بجه بنبدأ
+
+511
+00:45:17,220 --> 00:45:22,220
+نعطيه glucose اللي هو برضه intravenously و لازم
+
+512
+00:45:22,220 --> 00:45:25,760
+يعني بتتم بالمستشفى لأنه يعني موضوع أنه نعطي لا
+
+513
+00:45:25,760 --> 00:45:31,460
+المريض insulin طبعا يعني مش سهل و ممكن الشخص إذا
+
+514
+00:45:31,460 --> 00:45:35,320
+مافيش عندنا متابعة مستمرة للجلوس في الدم ممكن
+
+515
+00:45:35,320 --> 00:45:42,240
+الشخص يدخل بـ hypoglycemia يبقى insulinومن ناحية
+
+516
+00:45:42,240 --> 00:45:47,680
+تانية بنعطيه Glucose وفيه متابعة مستمرة لـ Glucose
+
+517
+00:45:47,680 --> 00:45:50,420
+Concentration على أساس إنه الـ Glucose
+
+518
+00:45:50,420 --> 00:45:54,900
+Concentration تكون نفس الـ Concentration اللي هو
+
+519
+00:45:54,900 --> 00:45:59,700
+في إذا كان الشخص صايم، يعني من 70 ل110
+
+520
+00:46:02,350 --> 00:46:04,370
+عبر مجال الوضع اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ
+
+521
+00:46:04,370 --> 00:46:06,890
+اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ
+
+522
+00:46:06,890 --> 00:46:11,430
+اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ
+
+523
+00:46:11,430 --> 00:46:11,470
+اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ
+
+524
+00:46:11,470 --> 00:46:12,930
+اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ
+
+525
+00:46:12,930 --> 00:46:14,670
+اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ
+
+526
+00:46:14,670 --> 00:46:15,210
+اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ
+
+527
+00:46:15,210 --> 00:46:16,710
+اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ
+
+528
+00:46:16,710 --> 00:46:19,530
+اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ
+
+529
+00:46:19,530 --> 00:46:24,830
+اللاجئ اللاجئ اللاجئ
+
+530
+00:46:24,830 --> 00:46:29,280
+اللاجهنلاقي إنه ال .. هدول الناس هيكون في عندهم
+
+531
+00:46:29,280 --> 00:46:35,880
+زيادة في ال endogenous insulinتمام؟ و الحالة
+
+532
+00:46:35,880 --> 00:46:41,900
+التانية أنه يكون في عنا اللي هو hyperglycemia يبقى
+
+533
+00:46:41,900 --> 00:46:47,900
+حالاجي انه ال .. ال glucose concentration يعني
+
+534
+00:46:47,900 --> 00:46:51,900
+مرتفع و أكتر من اللي هو ال normal fasting
+
+535
+00:46:51,900 --> 00:46:56,960
+concentration طبعاً مع ال large doses of exogenous
+
+536
+00:46:56,960 --> 00:47:01,080
+insulin اللي زي ما قلنا بتمحقنها at a constant
+
+537
+00:47:01,080 --> 00:47:02,680
+concentration
+
+538
+00:47:05,210 --> 00:47:08,990
+يبقى المريض، زي ما قلنا بنعطيه الـ Constant
+
+539
+00:47:08,990 --> 00:47:14,950
+Insulin Infusion وعناها Variable Glucose Infusion
+
+540
+00:47:14,950 --> 00:47:19,570
+وفي عنا اللي هو Frequent Blood Sampling عشان انقاذ
+
+541
+00:47:19,570 --> 00:47:27,170
+مستوى الـ Glucose وعنا زي ما قلنا Variable Glucose
+
+542
+00:47:27,170 --> 00:47:30,350
+Infusion يعني دايما فيه بناء على الـ Concentration
+
+543
+00:47:31,420 --> 00:47:36,580
+adjust a glucose infusion to اللي هو clam blood
+
+544
+00:47:36,580 --> 00:47:38,220
+glucose levels
+
+545
+00:47:40,900 --> 00:47:45,200
+يبقى من خلال الـ… الـEuglycemic اللي هو Glucose
+
+546
+00:47:45,200 --> 00:47:49,400
+إقلام يبقى بنشوف بطريقة مباشرة measure of the
+
+547
+00:47:49,400 --> 00:47:53,400
+whole body glucose disposal بنشوف قداش الجسم قادر
+
+548
+00:47:53,400 --> 00:47:57,960
+على التخلص من الجلوكوز اللي قاعدين نعمله infusion
+
+549
+00:47:57,960 --> 00:48:02,060
+at a given level of insulinemia زي ما قولنا عندنا
+
+550
+00:48:02,060 --> 00:48:08,990
+اللي هو constant infusion ofinsulin under steady
+
+551
+00:48:08,990 --> 00:48:17,510
+state conditions وزي ما شوفنا أنه يعني ممكن إذا
+
+552
+00:48:17,510 --> 00:48:20,910
+كان عندنا ال glucose concentration اللي هو طبيعي
+
+553
+00:48:20,910 --> 00:48:27,370
+مع زيادة في ال insulin concentration أو مع ال
+
+554
+00:48:27,370 --> 00:48:31,410
+oxygenous insulin زي ما قلنا ممكن الجسم يكون برضه
+
+555
+00:48:31,410 --> 00:48:35,480
+غير قادرعلى التعامل مع كميات الـ Glucose اللي
+
+556
+00:48:35,480 --> 00:48:41,740
+بتدخل لجسم لأنه الـ Insulin Resistance عالية ذكرنا
+
+557
+00:48:41,740 --> 00:48:44,660
+إنه في حالات أخرى برضه بيصير فيها إنها اللي هو
+
+558
+00:48:44,660 --> 00:48:47,200
+Insulin Resistance ومنها دي الحالات اللي هو
+
+559
+00:48:47,200 --> 00:48:51,740
+Syndrome X أو ما يُعرف بالـ Metabolic Syndrome
+
+560
+00:48:51,740 --> 00:48:55,060
+Group of Associated Clinical and Laboratory
+
+561
+00:48:55,060 --> 00:48:59,120
+Finding وهدول أشخاص بيكون في عندهم Insulin
+
+562
+00:48:59,120 --> 00:49:03,080
+Resistanceبيكون فيه hyperinsulinemia ارتفاع في
+
+563
+00:49:03,080 --> 00:49:06,120
+اللي هو الـ insulin concentration، obesity، و
+
+564
+00:49:06,120 --> 00:49:10,060
+dyslipidemia اللي هو بتشمل ارتفاع في الـ
+
+565
+00:49:10,060 --> 00:49:18,620
+triglycerides، اللي هو الانخفاض
+
+566
+00:49:18,620 --> 00:49:24,120
+في الـ high density lipoprotein، وموجود أيضًا
+
+567
+00:49:24,120 --> 00:49:27,910
+hypertensionالشخصين الذين يمتلوا هذا الاندروام
+
+568
+00:49:27,910 --> 00:49:34,510
+يكونوا في أكتر فرصة لمرحلة الكاردوفاسكالية طبعا
+
+569
+00:49:34,510 --> 00:49:38,980
+بالنسبة لل type 2 diabetes mellitusالـ Genetics
+
+570
+00:49:38,980 --> 00:49:44,740
+بتلعب دور أكبر يبقى وجود الـ Genetic Factors بتخلي
+
+571
+00:49:44,740 --> 00:49:50,140
+الشخص يعني طبعاً at higher risk لإصابة بالـ Type 2
+
+572
+00:49:50,140 --> 00:49:53,060
+Diabetes Mellitus طبعاً مع وجود الـ Environmental
+
+573
+00:49:53,060 --> 00:49:59,040
+Factors يعني لاحقاً Environmental Factors such as
+
+574
+00:49:59,040 --> 00:50:02,380
+diet and exercise are important determinants in
+
+575
+00:50:02,380 --> 00:50:05,860
+the pathogenesis of Type 2 Diabetes Mellitus يبقى
+
+576
+00:50:05,860 --> 00:50:11,020
+الـ diet و الـ exerciseو إذا كان ال genetic
+
+577
+00:50:11,020 --> 00:50:18,640
+factors موجودة و الشخص مش محافظ يعني على غذاء
+
+578
+00:50:18,640 --> 00:50:27,260
+سليم، فيش exercise، حياته فيش فيها حركة، فيه خمول،
+
+579
+00:50:27,260 --> 00:50:32,940
+يبقى معناته هذا الشخص يعني معرض بشكل كبير للإصابة
+
+580
+00:50:32,940 --> 00:50:38,900
+بال type 2 diabetes malatusالوثيقة الوثيقة الوثيقة
+
+581
+00:50:38,900 --> 00:50:40,880
+الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة
+
+582
+00:50:40,880 --> 00:50:45,700
+الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة
+
+583
+00:50:45,700 --> 00:50:53,540
+الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة
+
+584
+00:50:53,540 --> 00:50:56,560
+الوثيقة
+
+585
+00:50:57,020 --> 00:51:02,500
+يعني إما obese أو overweight، يبقى فيه عندنا علاقة
+
+586
+00:51:02,500 --> 00:51:06,900
+بين الـ obesity وبين الـ type 2 diabetes mellitus
+
+587
+00:51:10,840 --> 00:51:17,580
+طيب هل كل الأشخاص ال .. ال .. ال obese يعني ممكن
+
+588
+00:51:17,580 --> 00:51:21,800
+يصابوا أو لازم يصابوا بـ type 2 diabetes malatus
+
+589
+00:51:21,800 --> 00:51:28,220
+لأ يعني عندنا ال .. ال .. الأشخاص اللي هو ال .. ال
+
+590
+00:51:28,220 --> 00:51:31,820
+obese less than 15 percent of obese individuals
+
+591
+00:51:31,820 --> 00:51:39,180
+will develop diabetes تمام؟جهد مرتبط بممكن الـ
+
+592
+00:51:39,180 --> 00:51:41,220
+Genetic Factors، يعني ممكن الـ Genetic Factors ما
+
+593
+00:51:41,220 --> 00:51:44,700
+تكونش موجودة، لكن يكون الشخص اللي هو obese ومافيش
+
+594
+00:51:44,700 --> 00:51:48,580
+exercise والأمور الأخرى، لكن إذا كان الـ Genetic
+
+595
+00:51:48,580 --> 00:51:55,180
+Factors موجودة والشخص كان obese ومافيش exercise
+
+596
+00:51:55,180 --> 00:51:58,660
+والـ Risk Factors الأخرى، يبقى ممكن يصاب بالـ Type
+
+597
+00:51:58,660 --> 00:52:02,820
+2 Diabetes Malicious، بقى مش شرط أنه عشان obese
+
+598
+00:52:02,820 --> 00:52:07,980
+يصاب، لكن زي ما قلنا أنه فيإذا الـ genetic factors
+
+599
+00:52:07,980 --> 00:52:12,520
+موجودة و الشخص كان obese يبقى معناته الفرصة أكبر
+
+600
+00:52:12,520 --> 00:52:16,560
+أن يصاب بي الـ type 2 diabetes mellitus إن 60% to
+
+601
+00:52:16,560 --> 00:52:20,320
+80% of patients with type 2 diabetes mellitus are
+
+602
+00:52:20,320 --> 00:52:21,200
+obese
+
+603
+00:52:26,260 --> 00:52:29,900
+يبقى ممكن الشخص يكون obese لكن ما عندهوش اللي هو
+
+604
+00:52:29,900 --> 00:52:34,340
+type 2 diabetes mellitus لكن هلاجي أنه في عنده
+
+605
+00:52:34,340 --> 00:52:39,220
+مشكلة بيه اللي هو ال carbohydrate tolerance في
+
+606
+00:52:39,220 --> 00:52:43,060
+التعامل مع ال carbohydrates ويدو الأشخاص هلاجي أنه
+
+607
+00:52:43,060 --> 00:52:47,100
+في عندهم hyperinsulinemia and are insulin
+
+608
+00:52:47,100 --> 00:52:48,220
+resistant
+
+609
+00:52:50,730 --> 00:52:54,910
+يبقى عندنا اللي هو الـ Obesity عامل في الـ Genetic
+
+610
+00:52:54,910 --> 00:52:57,250
+Predisposition و اللي هو الـ Family History طبعاً
+
+611
+00:52:57,250 --> 00:52:59,810
+يفتح بتوعي ده باسم الـ Lettuce و ان الـ Duration
+
+612
+00:52:59,810 --> 00:53:04,850
+of Obesity و الـ Distribution of Fat يبقى كمان
+
+613
+00:53:04,850 --> 00:53:09,290
+اللي هو مناطق توزيع الـ Fat و طبعاً إذا كان اللي
+
+614
+00:53:09,290 --> 00:53:14,570
+هو الـ Fat موزع في اللي هو الـ Trunk أو في موزع في
+
+615
+00:53:14,570 --> 00:53:19,920
+اللي هو منطقة ال .. الوسط تمام يبقىهدول الوقت هي
+
+616
+00:53:19,920 --> 00:53:26,300
+الـ risk للإصابة بـ Type 2 Diabetes Mellitus It is
+
+617
+00:53:26,300 --> 00:53:28,840
+important to note that intervention can delay or
+
+618
+00:53:28,840 --> 00:53:32,920
+prevent the onset of Type 2 Diabetes Mellitus طبعا
+
+619
+00:53:32,920 --> 00:53:36,240
+إذا كان الشخص ما يصاب بـ Type 2 Diabetes Mellitus
+
+620
+00:53:36,240 --> 00:53:43,930
+فهنا مرحلة الـ pre-diabetes الآن في هذه المرحلةإذا
+
+621
+00:53:43,930 --> 00:53:52,250
+كان صار فيه تدخل وصار فيه تنظيم للأكل صار فيه
+
+622
+00:53:52,250 --> 00:53:57,290
+exercise صار فيه حركة عند هذا الشخص بيبقى ممكن
+
+623
+00:53:57,290 --> 00:54:02,330
+فعليًا يعني نأخر أو نمنع من حدوث الـ Type 2
+
+624
+00:54:02,330 --> 00:54:08,730
+Diabetes Mellitus وهذا تم طبعًا إثباته من خلال
+
+625
+00:54:08,730 --> 00:54:10,170
+اللي هو دراسات
+
+626
+00:54:12,560 --> 00:54:14,120
+تو عملية عملية عملية عملية عملية عملية عملية عملية
+
+627
+00:54:14,120 --> 00:54:14,700
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+628
+00:54:14,700 --> 00:54:18,340
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+629
+00:54:18,340 --> 00:54:20,260
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+630
+00:54:20,260 --> 00:54:24,260
+عملية عملية عملية عملية عملية عملية
+
+631
+00:54:24,260 --> 00:54:24,320
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+632
+00:54:24,320 --> 00:54:24,860
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+633
+00:54:24,860 --> 00:54:26,940
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+634
+00:54:26,940 --> 00:54:32,430
+عملية عملية عملية عمليةوهي مش شرط أن يكون الخسارة
+
+635
+00:54:32,430 --> 00:54:37,270
+لوزن بشكل كبير عشان نقلل من ال risk يعني ال weight
+
+636
+00:54:37,270 --> 00:54:41,210
+loss was modest صار فيه نقص بالوزن الو خمسة إلى
+
+637
+00:54:41,210 --> 00:54:46,190
+سبعة بالمية لكن the rate of progression to type 2
+
+638
+00:54:46,190 --> 00:54:48,770
+diabetes pellitus was reduced by fifty eight
+
+639
+00:54:48,770 --> 00:54:54,910
+percentin both studies، حتى مع خسارة بالوزن بنسبة
+
+640
+00:54:54,910 --> 00:55:00,830
+قليلة، إلا إن هذه الخسارة بتقلل من احتمالية
+
+641
+00:55:00,830 --> 00:55:05,070
+الإصابة بالـ Type 2 diabetes mellitus بنسبة كبيرة،
+
+642
+00:55:05,070 --> 00:55:11,250
+اللي هو زي ما واضح من هدول الدراسين، 58%. This
+
+643
+00:55:11,250 --> 00:55:14,410
+observation has been validated by several other
+
+644
+00:55:14,410 --> 00:55:18,650
+studies، كمان دراسات أخرى أكدت هذا الموضوع.
+
+645
+00:55:21,300 --> 00:55:26,640
+وفي عندنا اللي هو علاقة عكسية بين الـ degree of
+
+646
+00:55:26,640 --> 00:55:30,680
+physical activity and the prevalence of type 2
+
+647
+00:55:30,680 --> 00:55:38,020
+diabetes mellitus النقطة الأخرى اللي هو عندنا الـ
+
+648
+00:55:38,020 --> 00:55:41,800
+geneticsوزي ما قلنا إن الـ Genetics في الـ type 2
+
+649
+00:55:41,800 --> 00:55:45,500
+diabetes mellitus يعني بتلعب دور أكبر، it is
+
+650
+00:55:45,500 --> 00:55:47,820
+widely acknowledged that genetic factors
+
+651
+00:55:47,820 --> 00:55:51,240
+contribute to the development of type 2 diabetes
+
+652
+00:55:51,240 --> 00:55:56,720
+mellitus ولمّا نحكي على ال concordance rate for
+
+653
+00:55:56,720 --> 00:55:59,720
+type 2 diabetes mellitus in identical twins
+
+654
+00:55:59,720 --> 00:56:03,360
+approaches 100%
+
+655
+00:56:05,950 --> 00:56:09,390
+ويقولنا إن الـ genetic factors مهمة وبالتالي type
+
+656
+00:56:09,390 --> 00:56:12,170
+2 diabetes mellitus is ten times more likely to
+
+657
+00:56:12,170 --> 00:56:16,210
+occur in an obese person with a diabetic parent
+
+658
+00:56:16,210 --> 00:56:21,510
+بما أنته فيه هنا إن ال genetic factors موجودة وإن
+
+659
+00:56:21,510 --> 00:56:24,030
+احتماليتي بإصابة هذا الشخص بيقل type 2 diabetes
+
+660
+00:56:24,030 --> 00:56:30,870
+mellitus زي ما يقولون طبعا بـ equally obese person
+
+661
+00:56:30,870 --> 00:56:33,530
+without a diabetic family history
+
+662
+00:56:35,960 --> 00:56:39,740
+However, the mood of inheritance is unknown
+
+663
+00:56:43,890 --> 00:56:49,530
+طب ما في عندنا أمراض عديدة بتكون المشكلة موجودة في
+
+664
+00:56:49,530 --> 00:56:55,030
+اللي هو single locus زي cystic fibrosis زي Deutsch
+
+665
+00:56:55,030 --> 00:57:00,470
+-Niemuscular Dystrophy لكن بما يتعلق بالـDiabetes
+
+666
+00:57:00,470 --> 00:57:08,750
+Mellitus هان عندنا المشكلة بتتعلق بـMultiple
+
+667
+00:57:08,750 --> 00:57:13,570
+Genetic Factorsوهذه الوضعيات أكتر مجنونة جنوناتيا
+
+668
+00:57:13,570 --> 00:57:18,390
+ومجموعة من الوضعيات الجنوانية تتعامل مع انفلوانات
+
+669
+00:57:18,390 --> 00:57:19,710
+إكسوجينية
+
+670
+00:57:27,310 --> 00:57:32,830
+factors وطبعا من هذه الأمراض اللي عندنا multi
+
+671
+00:57:32,830 --> 00:57:35,550
+genetic factors ممكن اللي هو تكون بتلعب دور زي الـ
+
+672
+00:57:35,550 --> 00:57:38,150
+diabetes mellitus زي الـ atherosclerosis،
+
+673
+00:57:38,150 --> 00:57:41,590
+hypertension، osteoporosis
+
+674
+00:57:44,400 --> 00:57:49,540
+طبعًا باستخدام اللي هو طرق مختلفة تم الكشف عن يعني
+
+675
+00:57:49,540 --> 00:57:56,220
+عدد من الجينات اللي لها علاقة بالاصابة بـ Type 2
+
+676
+00:57:56,220 --> 00:58:02,300
+Diabetes Mellitus وعنا من الدراسات اللي تم
+
+677
+00:58:02,300 --> 00:58:04,900
+استخدامها اللي هو الـ Genome-wide Association
+
+678
+00:58:04,900 --> 00:58:13,900
+Studies وهذا النوع من الدراسات يعني طبعًا إشارةأو
+
+679
+00:58:13,900 --> 00:58:21,260
+كان له دور كبير في ربط العديد من الـ genes بمرض
+
+680
+00:58:21,260 --> 00:58:24,580
+اللي هو الـ type 2 diabetes malatus with more than
+
+681
+00:58:24,580 --> 00:58:29,180
+60 genetic low key now identified
+
diff --git a/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/0H-DC7bobLw_raw.json b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/0H-DC7bobLw_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..23aaa97947c45f69970bfc04278111b4a00f6f08
--- /dev/null
+++ b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/0H-DC7bobLw_raw.json
@@ -0,0 +1 @@
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"tokens": [27842, 2423, 39184, 5130, 897, 6087, 13672, 1829, 39894, 30544, 3714, 29245, 23328, 3660, 8978, 11331, 6027, 9307, 2423, 39184, 15576, 502, 13881, 385, 285, 30973, 6156, 9957, 995, 25062, 9640, 3660, 28859, 383, 4328, 404, 7743, 13195, 5130, 897, 6087, 37037, 24192, 2423, 39184, 5130, 897, 6087, 39894, 29399, 7435, 48812, 3215, 14739, 2655, 7435, 9957], "avg_logprob": -0.25538792332698557, "compression_ratio": 1.3397435897435896, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 1000.94, "end": 1001.26, "word": "من", "probability": 0.953125}, {"start": 1001.26, "end": 1001.46, "word": " الـ", "probability": 0.988525390625}, {"start": 1001.46, "end": 1002.22, "word": " Antibodies", "probability": 0.7826334635416666}, {"start": 1002.22, "end": 1002.98, "word": " اللي", "probability": 0.96435546875}, {"start": 1002.98, "end": 1005.26, "word": " بتكون", "probability": 0.967529296875}, {"start": 1005.26, "end": 1005.8, "word": " موجودة", "probability": 0.99072265625}, 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"probability": 0.962890625}, {"start": 1011.64, "end": 1013.34, "word": " وهذه", "probability": 0.635009765625}, {"start": 1013.34, "end": 1013.56, "word": " الـ", "probability": 0.932373046875}, {"start": 1013.56, "end": 1014.6, "word": " Antibodies", "probability": 0.9822591145833334}, {"start": 1014.6, "end": 1016.6, "word": " بتنتج", "probability": 0.9583333333333334}, {"start": 1016.6, "end": 1017.08, "word": " ضد", "probability": 0.992919921875}, {"start": 1017.08, "end": 1018.04, "word": " أنتجين", "probability": 0.769287109375}], "temperature": 1.0}, {"id": 47, "seek": 104594, "start": 1019.82, "end": 1045.94, "text": "يسمى سيالو إيجلوكو كونجيجيت أنتيجن وهذا الانتيجن موجود بالـCytoplasm of all endocrine cells of the pancreatic eyelids. These antibodies are detected in the serum of 0.5% of normal subjects، بما يمكن أن الـantibodies هذه كمان اللي جيها عند نسبة قليلة من الأشخاص السالمين، اللي هي تقريبا عن 0.5%", "tokens": [1829, 38251, 7578, 8608, 1829, 6027, 2407, 11933, 1829, 7435, 1211, 2407, 4117, 2407, 9122, 11536, 7435, 1829, 7435, 36081, 14739, 31371, 7435, 1863, 37037, 15730, 2423, 7649, 31371, 7435, 1863, 3714, 29245, 23328, 20666, 39184, 34, 4328, 404, 7743, 76, 295, 439, 917, 3617, 533, 5438, 295, 264, 2462, 35546, 299, 42419, 13, 1981, 28356, 366, 21896, 294, 264, 32755, 295, 1958, 13, 20, 4, 295, 2710, 1422, 1020, 82, 12399, 4724, 15042, 7251, 43020, 14739, 2423, 39184, 394, 897, 6087, 29538, 9122, 2304, 7649, 13672, 1829, 10874, 1829, 11296, 43242, 8717, 35457, 3660, 12174, 20292, 37977, 9154, 16247, 8592, 9778, 33546, 21136, 45340, 9957, 12399, 13672, 1829, 39896, 6055, 4587, 16572, 3555, 995, 18871, 1958, 13, 20, 4], "avg_logprob": -0.2598140456459739, "compression_ratio": 1.4964028776978417, 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"probability": 0.684521484375}, {"start": 1038.0, "end": 1038.24, "word": " هذه", "probability": 0.70703125}, {"start": 1038.24, "end": 1038.66, "word": " كمان", "probability": 0.89501953125}, {"start": 1038.66, "end": 1039.38, "word": " اللي", "probability": 0.854736328125}, {"start": 1039.38, "end": 1039.8, "word": " جيها", "probability": 0.7776692708333334}, {"start": 1039.8, "end": 1040.18, "word": " عند", "probability": 0.94580078125}, {"start": 1040.18, "end": 1040.68, "word": " نسبة", "probability": 0.9915364583333334}, {"start": 1040.68, "end": 1041.16, "word": " قليلة", "probability": 0.9832356770833334}, {"start": 1041.16, "end": 1041.48, "word": " من", "probability": 0.9921875}, {"start": 1041.48, "end": 1042.76, "word": " الأشخاص", "probability": 0.9918212890625}, {"start": 1042.76, "end": 1044.08, "word": " السالمين،", "probability": 0.904541015625}, {"start": 1044.08, "end": 1044.14, "word": " اللي", "probability": 0.87646484375}, {"start": 1044.14, "end": 1044.24, "word": " هي", "probability": 0.91796875}, {"start": 1044.24, "end": 1044.68, "word": " تقريبا", "probability": 0.94951171875}, {"start": 1044.68, "end": 1044.86, "word": " عن", "probability": 0.436279296875}, {"start": 1044.86, "end": 1045.06, "word": " 0", "probability": 0.833984375}, {"start": 1045.06, "end": 1045.5, "word": ".5", "probability": 0.992431640625}, {"start": 1045.5, "end": 1045.94, "word": "%", "probability": 0.9111328125}], "temperature": 1.0}, {"id": 48, "seek": 107268, "start": 1046.52, "end": 1072.68, "text": "of normal subjects لكن أكيد بتكون موجودة بيه عند الأشخاص المصابين بالـ Type 1 diabetes mellitus اللي هو 75% إلى 85% of patients with a newly diagnosed Type 1 diabetes mellitus have eyelid cell cytoplasmic antibodies عندنا antibody آخر برضه ممكن يكون موجود", "tokens": [2670, 2710, 13066, 44381, 5551, 4117, 25708, 39894, 30544, 3714, 29245, 23328, 3660, 4724, 1829, 3224, 43242, 16247, 8592, 9778, 33546, 9673, 9381, 16758, 9957, 20666, 39184, 15576, 502, 13881, 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{"start": 1050.1, "end": 1051.32, "word": " بيه", "probability": 0.5658365885416666}, {"start": 1051.32, "end": 1052.1, "word": " عند", "probability": 0.92578125}, {"start": 1052.1, "end": 1052.66, "word": " الأشخاص", "probability": 0.9923095703125}, {"start": 1052.66, "end": 1053.16, "word": " المصابين", "probability": 0.9666748046875}, {"start": 1053.16, "end": 1053.5, "word": " بالـ", "probability": 0.877685546875}, {"start": 1053.5, "end": 1053.64, "word": " Type", "probability": 0.57958984375}, {"start": 1053.64, "end": 1053.82, "word": " 1", "probability": 0.74267578125}, {"start": 1053.82, "end": 1054.06, "word": " diabetes", "probability": 0.5859375}, {"start": 1054.06, "end": 1054.64, "word": " mellitus", "probability": 0.89599609375}, {"start": 1054.64, "end": 1055.28, "word": " اللي", "probability": 0.955322265625}, {"start": 1055.28, "end": 1055.36, "word": " هو", "probability": 0.93505859375}, {"start": 1055.36, "end": 1055.8, "word": " 75", "probability": 0.92529296875}, {"start": 1055.8, "end": 1056.26, "word": "%", "probability": 0.712890625}, {"start": 1056.26, "end": 1056.44, "word": " إلى", "probability": 0.45654296875}, {"start": 1056.44, "end": 1057.18, "word": " 85", "probability": 0.97998046875}, {"start": 1057.18, "end": 1057.84, "word": "%", "probability": 0.97265625}, {"start": 1057.84, "end": 1058.66, "word": " of", "probability": 0.9765625}, {"start": 1058.66, "end": 1059.32, "word": " patients", "probability": 0.8583984375}, {"start": 1059.32, "end": 1060.14, "word": " with", "probability": 0.91748046875}, {"start": 1060.14, "end": 1060.32, "word": " a", "probability": 0.71044921875}, {"start": 1060.32, "end": 1060.62, "word": " newly", "probability": 0.9052734375}, {"start": 1060.62, "end": 1061.22, "word": " diagnosed", "probability": 0.83544921875}, {"start": 1061.22, "end": 1061.48, "word": " Type", "probability": 0.787109375}, {"start": 1061.48, "end": 1061.62, "word": " 1", "probability": 0.9697265625}, {"start": 1061.62, "end": 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50, "seek": 112682, "start": 1103.34, "end": 1126.82, "text": "يبقى الحالات اللي فوق سن الـ 12 بتلاقي أنه هذه الـ Antibodies موجودة بيه اللي هو تقريبا عند 40% أو أقل من هدول الأشخاص الـ Antibodies هذه برضه ممكن تصل إلى detection عند الأشخاص السالمين برضه بالنسبة قليلة لـ 0.5%", "tokens": [1829, 3555, 4587, 7578, 21542, 6027, 9307, 13672, 1829, 6156, 30543, 8608, 1863, 2423, 39184, 2272, 39894, 15040, 38436, 14739, 3224, 29538, 2423, 39184, 5130, 897, 6087, 3714, 29245, 23328, 3660, 4724, 1829, 3224, 13672, 1829, 31439, 6055, 4587, 16572, 3555, 995, 43242, 3356, 4, 34051, 5551, 4587, 1211, 9154, 8032, 3215, 12610, 16247, 8592, 9778, 33546, 2423, 39184, 5130, 897, 6087, 29538, 4724, 43042, 3224, 3714, 43020, 6055, 36520, 30731, 17784, 43242, 16247, 8592, 9778, 33546, 21136, 45340, 9957, 4724, 43042, 3224, 20666, 1863, 35457, 3660, 12174, 20292, 37977, 5296, 39184, 1958, 13, 20, 4], "avg_logprob": -0.16978093275089853, "compression_ratio": 1.6384976525821595, "no_speech_prob": 0.0, 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"word": " السالمين", "probability": 0.9296875}, {"start": 1122.94, "end": 1123.22, "word": " برضه", "probability": 0.9557291666666666}, {"start": 1123.22, "end": 1123.68, "word": " بالنسبة", "probability": 0.862060546875}, {"start": 1123.68, "end": 1124.24, "word": " قليلة", "probability": 0.96923828125}, {"start": 1124.24, "end": 1124.92, "word": " لـ", "probability": 0.5665283203125}, {"start": 1124.92, "end": 1125.16, "word": " 0", "probability": 0.947265625}, {"start": 1125.16, "end": 1125.86, "word": ".5", "probability": 0.99169921875}, {"start": 1125.86, "end": 1126.82, "word": "%", "probability": 0.82373046875}], "temperature": 1.0}, {"id": 51, "seek": 114004, "start": 1128.5, "end": 1140.04, "text": "ممكن أيضًا تتم الكشف عن antibodies لـ 65-kD-isoform of glutamic acid D-carboxylase الوالجاد 65", "tokens": [2304, 43020, 36632, 11242, 14111, 995, 6055, 39237, 33251, 8592, 5172, 18871, 28356, 5296, 39184, 11624, 12, 74, 35, 12, 271, 2670, 687, 295, 33249, 20726, 8258, 413, 12, 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"probability": 0.8681640625}, {"start": 1177.74, "end": 1177.98, "word": " you", "probability": 0.79443359375}, {"start": 1177.98, "end": 1178.12, "word": " اللي", "probability": 0.6373291015625}, {"start": 1178.12, "end": 1178.6, "word": " diagnosed", "probability": 0.2318115234375}, {"start": 1178.6, "end": 1178.98, "word": " type", "probability": 0.7236328125}, {"start": 1178.98, "end": 1179.22, "word": " 1", "probability": 0.51416015625}, {"start": 1179.22, "end": 1179.82, "word": " diabetes", "probability": 0.51318359375}, {"start": 1179.82, "end": 1180.98, "word": " مالليتاس", "probability": 0.8513671875}, {"start": 1180.98, "end": 1183.66, "word": " في", "probability": 0.4833984375}, {"start": 1183.66, "end": 1183.82, "word": " أن", "probability": 0.164794921875}, {"start": 1183.82, "end": 1184.28, "word": " بعض", "probability": 0.950927734375}, {"start": 1184.28, "end": 1184.84, "word": " الحالات", "probability": 0.9552408854166666}, {"start": 1184.84, "end": 1185.02, "word": " 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mellitus لكن إذا تم اللي هو الفحص الجاد 65 antibodies وطبعا تم الكشف عن هذه ال antibodies عند هذا اللي هو ال patient إيه بمعناته ال diagnosis الصحيح هيكون اللي هو type 1 diabetes", "tokens": [6027, 20292, 31439, 7970, 37495, 22653, 2010, 568, 13881, 385, 285, 30973, 44381, 11933, 15730, 46811, 13672, 1829, 31439, 27188, 5016, 9381, 25724, 18513, 11624, 28356, 4032, 9566, 3555, 3615, 995, 46811, 33251, 8592, 5172, 18871, 29538, 2423, 28356, 43242, 23758, 13672, 1829, 31439, 2423, 4537, 11933, 1829, 3224, 4724, 2304, 3615, 8315, 47395, 2423, 15217, 31767, 5016, 1829, 5016, 39896, 30544, 13672, 1829, 31439, 2010, 502, 13881], "avg_logprob": -0.1699501872062683, "compression_ratio": 1.6102564102564103, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1193.0, "end": 1194.04, "word": "اللي", "probability": 0.962158203125}, {"start": 1194.04, "end": 1194.18, "word": " هو", "probability": 0.91064453125}, {"start": 1194.18, "end": 1194.8, "word": " apparently", "probability": 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0.9892578125}, {"start": 1210.58, "end": 1210.76, "word": " هو", "probability": 0.99267578125}, {"start": 1210.76, "end": 1211.08, "word": " ال", "probability": 0.96240234375}, {"start": 1211.08, "end": 1211.7, "word": " patient", "probability": 0.92041015625}, {"start": 1211.7, "end": 1212.3, "word": " إيه", "probability": 0.7168782552083334}, {"start": 1212.3, "end": 1212.76, "word": " بمعناته", "probability": 0.91201171875}, {"start": 1212.76, "end": 1212.98, "word": " ال", "probability": 0.8271484375}, {"start": 1212.98, "end": 1213.44, "word": " diagnosis", "probability": 0.72119140625}, {"start": 1213.44, "end": 1214.52, "word": " الصحيح", "probability": 0.9898681640625}, {"start": 1214.52, "end": 1215.42, "word": " هيكون", "probability": 0.8916015625}, {"start": 1215.42, "end": 1215.62, "word": " اللي", "probability": 0.97021484375}, {"start": 1215.62, "end": 1215.76, "word": " هو", "probability": 0.95458984375}, {"start": 1215.76, "end": 1216.02, "word": " type", "probability": 0.98681640625}, {"start": 1216.02, "end": 1216.36, "word": " 1", "probability": 0.82470703125}, {"start": 1216.36, "end": 1217.22, "word": " diabetes", "probability": 0.8662109375}], "temperature": 1.0}, {"id": 55, "seek": 123918, "start": 1224.18, "end": 1239.18, "text": "اللي زي ما قلنا لو يعني بعد فترة من الزمن هلاجي أنه هذا الشخص فعليا اللي هو عنده type 1 diabetes mellitus ومش type 2", "tokens": [6027, 20292, 30767, 1829, 19446, 12174, 1211, 8315, 45164, 37495, 22653, 39182, 6156, 2655, 25720, 9154, 6024, 110, 27842, 8032, 15040, 7435, 1829, 14739, 3224, 23758, 25124, 9778, 9381, 6156, 3615, 20292, 995, 13672, 1829, 31439, 43242, 3224, 2010, 502, 13881, 385, 285, 30973, 4032, 2304, 8592, 2010, 568], "avg_logprob": -0.1915625035762787, "compression_ratio": 1.2816901408450705, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1224.18, "end": 1225.18, "word": "اللي", "probability": 0.3941650390625}, {"start": 1225.18, "end": 1226.18, "word": " زي", "probability": 0.80126953125}, {"start": 1226.18, "end": 1226.28, "word": " ما", "probability": 0.830078125}, {"start": 1226.28, "end": 1226.52, "word": " قلنا", "probability": 0.7314453125}, {"start": 1226.52, "end": 1226.86, "word": " لو", "probability": 0.89501953125}, {"start": 1226.86, "end": 1228.94, "word": " يعني", "probability": 0.97509765625}, {"start": 1228.94, "end": 1229.56, "word": " بعد", "probability": 0.96142578125}, {"start": 1229.56, "end": 1229.96, "word": " فترة", "probability": 0.99609375}, {"start": 1229.96, "end": 1230.14, "word": " من", "probability": 0.9931640625}, {"start": 1230.14, "end": 1230.44, "word": " الزمن", "probability": 0.8982747395833334}, {"start": 1230.44, "end": 1231.16, "word": " هلاجي", "probability": 0.8345947265625}, {"start": 1231.16, "end": 1232.08, "word": " أنه", "probability": 0.61572265625}, {"start": 1232.08, "end": 1232.5, "word": " هذا", "probability": 0.91552734375}, {"start": 1232.5, "end": 1232.98, "word": " الشخص", "probability": 0.99267578125}, {"start": 1232.98, "end": 1233.68, "word": " فعليا", "probability": 0.8585205078125}, {"start": 1233.68, "end": 1234.46, "word": " اللي", "probability": 0.921630859375}, {"start": 1234.46, "end": 1234.72, "word": " هو", "probability": 0.96337890625}, {"start": 1234.72, "end": 1235.16, "word": " عنده", "probability": 0.983642578125}, {"start": 1235.16, "end": 1235.46, "word": " type", "probability": 0.7197265625}, {"start": 1235.46, "end": 1235.82, "word": " 1", "probability": 0.46826171875}, {"start": 1235.82, "end": 1236.68, "word": " diabetes", "probability": 0.65087890625}, {"start": 1236.68, "end": 1237.26, "word": " mellitus", "probability": 0.857421875}, {"start": 1237.26, "end": 1238.16, "word": " ومش", "probability": 0.8308919270833334}, {"start": 1238.16, "end": 1238.68, "word": " type", "probability": 0.98291015625}, {"start": 1238.68, "end": 1239.18, "word": " 2", "probability": 0.94287109375}], "temperature": 1.0}, {"id": 56, "seek": 126086, "start": 1241.25, "end": 1260.87, "text": "ذكرنا سابقاً إنه الـtype 2 diabetes mellitus patients يعني ممكن في مراحل متقدمة يعني بيصبحوا يعتمدوا على الـexogenous انسلين لكن في بعض الحالات اللي هو الـtype 2 diabetes mellitus", "tokens": [8848, 37983, 8315, 8608, 16758, 4587, 995, 14111, 36145, 3224, 2423, 39184, 20467, 568, 13881, 385, 285, 30973, 4209, 37495, 22653, 3714, 43020, 8978, 3714, 23557, 5016, 1211, 44650, 28543, 46007, 37495, 22653, 4724, 1829, 9381, 49628, 14407, 7251, 34268, 2304, 3215, 14407, 15844, 2423, 39184, 3121, 45519, 16472, 3794, 1211, 9957, 44381, 8978, 45030, 11242, 21542, 6027, 9307, 13672, 1829, 31439, 2423, 39184, 20467, 568, 13881, 385, 285, 30973], "avg_logprob": -0.15702024102210999, "compression_ratio": 1.5224719101123596, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 1241.25, "end": 1242.17, "word": "ذكرنا", "probability": 0.8209635416666666}, {"start": 1242.17, "end": 1242.91, "word": " سابقاً", "probability": 0.86220703125}, {"start": 1242.91, 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{"start": 1251.01, "end": 1251.75, "word": " بيصبحوا", "probability": 0.9802734375}, {"start": 1251.75, "end": 1252.47, "word": " يعتمدوا", "probability": 0.9681640625}, {"start": 1252.47, "end": 1252.87, "word": " على", "probability": 0.94482421875}, {"start": 1252.87, "end": 1254.49, "word": " الـexogenous", "probability": 0.8037109375}, {"start": 1254.49, "end": 1255.91, "word": " انسلين", "probability": 0.75677490234375}, {"start": 1255.91, "end": 1258.41, "word": " لكن", "probability": 0.8486328125}, {"start": 1258.41, "end": 1258.69, "word": " في", "probability": 0.99072265625}, {"start": 1258.69, "end": 1258.99, "word": " بعض", "probability": 0.95751953125}, {"start": 1258.99, "end": 1259.37, "word": " الحالات", "probability": 0.8566080729166666}, {"start": 1259.37, "end": 1259.51, "word": " اللي", "probability": 0.9365234375}, {"start": 1259.51, "end": 1259.57, "word": " هو", "probability": 0.93212890625}, {"start": 1259.57, "end": 1259.83, "word": " الـtype", "probability": 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أيضًا الزيادة بالـ Free fatty acids يبقى برضه هذه بتلعب دور في الـ Beta cell failure وهذا ما يُعرف بالـ Lipotoxicity عندنا أيضًا المشكلة اللي ذكرناها سابقًا اللي هو الـ disruption of the normal pulsatile release", "tokens": [27842, 8717, 39319, 10632, 6055, 7649, 10632, 12399, 43242, 8315, 36632, 11242, 14111, 995, 6024, 110, 1829, 18513, 3660, 20666, 39184, 11551, 24898, 21667, 7251, 3555, 4587, 7578, 4724, 43042, 3224, 29538, 39894, 1211, 3615, 3555, 11778, 13063, 8978, 2423, 39184, 33286, 2815, 7763, 37037, 15730, 19446, 7251, 10859, 3615, 28480, 20666, 39184, 27475, 310, 5230, 44198, 43242, 8315, 36632, 11242, 14111, 995, 9673, 8592, 28820, 3660, 13672, 1829, 29910, 37983, 8315, 11296, 8608, 16758, 4587, 14111, 995, 13672, 1829, 31439, 2423, 39184, 28751, 295, 264, 2710, 32295, 17445, 4374], "avg_logprob": -0.14217032672284724, "compression_ratio": 1.4914529914529915, "no_speech_prob": 0.0, "words": [{"start": 2423.43, "end": 2423.63, "word": "من", "probability": 0.86474609375}, {"start": 2423.63, "end": 2423.97, "word": " ناحية", "probability": 0.9700520833333334}, {"start": 2423.97, "end": 2424.47, "word": " تانية،", "probability": 0.849609375}, {"start": 2424.47, "end": 2424.67, "word": " عندنا", "probability": 0.74365234375}, {"start": 2424.67, "end": 2425.31, "word": " أيضًا", "probability": 0.9495849609375}, {"start": 2425.31, "end": 2426.51, "word": " الزيادة", "probability": 0.862841796875}, {"start": 2426.51, "end": 2426.83, "word": " بالـ", "probability": 0.84326171875}, {"start": 2426.83, "end": 2427.21, "word": " Free", "probability": 0.59033203125}, {"start": 2427.21, "end": 2427.95, "word": " fatty", "probability": 0.481689453125}, {"start": 2427.95, "end": 2428.63, "word": " acids", "probability": 0.76123046875}, {"start": 2428.63, "end": 2429.79, "word": " يبقى", "probability": 0.7576904296875}, {"start": 2429.79, "end": 2430.11, "word": " برضه", "probability": 0.9347330729166666}, {"start": 2430.11, "end": 2430.43, "word": " هذه", 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"probability": 0.8585205078125}, {"start": 2438.61, "end": 2440.85, "word": " عندنا", "probability": 0.95556640625}, {"start": 2440.85, "end": 2441.13, "word": " أيضًا", "probability": 0.9866943359375}, {"start": 2441.13, "end": 2441.67, "word": " المشكلة", "probability": 0.9931640625}, {"start": 2441.67, "end": 2441.97, "word": " اللي", "probability": 0.940673828125}, {"start": 2441.97, "end": 2442.89, "word": " ذكرناها", "probability": 0.9827880859375}, {"start": 2442.89, "end": 2444.11, "word": " سابقًا", "probability": 0.9775390625}, {"start": 2444.11, "end": 2445.75, "word": " اللي", "probability": 0.91552734375}, {"start": 2445.75, "end": 2445.89, "word": " هو", "probability": 0.9580078125}, {"start": 2445.89, "end": 2446.03, "word": " الـ", "probability": 0.90185546875}, {"start": 2446.03, "end": 2446.43, "word": " disruption", "probability": 0.560546875}, {"start": 2446.43, "end": 2446.89, "word": " of", "probability": 0.9775390625}, {"start": 2446.89, "end": 2447.09, "word": " the", "probability": 0.89501953125}, {"start": 2447.09, "end": 2447.55, "word": " normal", "probability": 0.8720703125}, {"start": 2447.55, "end": 2448.43, "word": " pulsatile", "probability": 0.79541015625}, {"start": 2448.43, "end": 2449.11, "word": " release", "probability": 0.77490234375}], "temperature": 1.0}, {"id": 109, "seek": 246766, "start": 2449.56, "end": 2467.66, "text": "وانسلين هذا ذكرنا سابقا ان الناس اللي عندهم type 2 diabetes mellitus اللي هو بيفقدوا ال normal pulsatile release of انسلين and an increase ratio of plasma pro insulin to insulin", "tokens": [2407, 7649, 3794, 1211, 9957, 23758, 29910, 37983, 8315, 8608, 16758, 4587, 995, 16472, 2423, 8315, 3794, 13672, 1829, 43242, 16095, 2010, 568, 13881, 385, 285, 30973, 13672, 1829, 31439, 4724, 33911, 28543, 14407, 2423, 2710, 32295, 17445, 4374, 295, 16472, 3794, 1211, 9957, 293, 364, 3488, 8509, 295, 22564, 447, 21587, 281, 21587], "avg_logprob": -0.3522727294401689, "compression_ratio": 1.4096385542168675, 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"temperature": 1.0}, {"id": 147, "seek": 333834, "start": 3321.3, "end": 3338.34, "text": "وفي عندنا اللي هو علاقة عكسية بين الـ degree of physical activity and the prevalence of type 2 diabetes mellitus النقطة الأخرى اللي هو عندنا الـ genetics", "tokens": [38688, 1829, 43242, 8315, 13672, 1829, 31439, 11203, 995, 28671, 6225, 4117, 3794, 10632, 49374, 2423, 39184, 4314, 295, 4001, 5191, 293, 264, 42583, 295, 2010, 568, 13881, 385, 285, 30973, 28239, 47432, 3660, 16247, 34740, 7578, 13672, 1829, 31439, 43242, 8315, 2423, 39184, 26516], "avg_logprob": -0.21756114519160727, "compression_ratio": 1.3312101910828025, "no_speech_prob": 0.0, "words": [{"start": 3321.3, "end": 3321.82, "word": "وفي", "probability": 0.922119140625}, {"start": 3321.82, "end": 3322.14, "word": " عندنا", "probability": 0.54156494140625}, {"start": 3322.14, "end": 3322.28, "word": " اللي", "probability": 0.722900390625}, {"start": 3322.28, "end": 3322.4, "word": " هو", "probability": 0.958984375}, {"start": 3322.4, 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1.0}, {"id": 149, "seek": 339353, "start": 3365.95, "end": 3393.53, "text": "ويقولنا إن الـ genetic factors مهمة وبالتالي type 2 diabetes mellitus is ten times more likely to occur in an obese person with a diabetic parent بما أنته فيه هنا إن ال genetic factors موجودة وإن احتماليتي بإصابة هذا الشخص بيقل type 2 diabetes mellitus زي ما يقولون طبعا بـ equally obese person without a diabetic family history", "tokens": [2407, 1829, 39648, 8315, 36145, 2423, 39184, 12462, 6771, 3714, 16095, 3660, 46599, 6027, 2655, 6027, 1829, 2010, 568, 13881, 385, 285, 30973, 307, 2064, 1413, 544, 3700, 281, 5160, 294, 364, 50060, 954, 365, 257, 50238, 2596, 4724, 15042, 14739, 47395, 8978, 3224, 34105, 36145, 2423, 12462, 6771, 3714, 29245, 23328, 3660, 4032, 28814, 1863, 1975, 33753, 2304, 6027, 1829, 31371, 4724, 28814, 9381, 16758, 3660, 23758, 25124, 9778, 9381, 4724, 1829, 4587, 1211, 2010, 568, 13881, 385, 285, 30973, 30767, 1829, 19446, 7251, 39648, 11536, 23032, 3555, 3615, 995, 4724, 39184, 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"word": " زي", "probability": 0.7001953125}, {"start": 3387.09, "end": 3387.21, "word": " ما", "probability": 0.9931640625}, {"start": 3387.21, "end": 3387.65, "word": " يقولون", "probability": 0.591796875}, {"start": 3387.65, "end": 3388.51, "word": " طبعا", "probability": 0.9637451171875}, {"start": 3388.51, "end": 3389.37, "word": " بـ", "probability": 0.535400390625}, {"start": 3389.37, "end": 3390.13, "word": " equally", "probability": 0.7548828125}, {"start": 3390.13, "end": 3390.45, "word": " obese", "probability": 0.927734375}, {"start": 3390.45, "end": 3390.87, "word": " person", "probability": 0.921875}, {"start": 3390.87, "end": 3391.27, "word": " without", "probability": 0.9228515625}, {"start": 3391.27, "end": 3391.65, "word": " a", "probability": 0.97119140625}, {"start": 3391.65, "end": 3391.97, "word": " diabetic", "probability": 0.9423828125}, {"start": 3391.97, "end": 3392.57, "word": " family", "probability": 0.9248046875}, {"start": 3392.57, "end": 3393.53, "word": " history", "probability": 0.92333984375}], "temperature": 1.0}, {"id": 150, "seek": 339974, "start": 3395.96, "end": 3399.74, "text": "However, the mood of inheritance is unknown", "tokens": [6462, 1054, 11, 264, 9268, 295, 32122, 307, 9841], "avg_logprob": -0.3693359434604645, "compression_ratio": 0.8431372549019608, "no_speech_prob": 0.0, "words": [{"start": 3395.96, "end": 3396.46, "word": "However,", "probability": 0.56005859375}, {"start": 3396.56, "end": 3396.64, "word": " the", "probability": 0.7763671875}, {"start": 3396.64, "end": 3396.96, "word": " mood", "probability": 0.7939453125}, {"start": 3396.96, "end": 3397.38, "word": " of", "probability": 0.982421875}, {"start": 3397.38, "end": 3398.28, "word": " inheritance", "probability": 0.9169921875}, {"start": 3398.28, "end": 3399.06, "word": " is", "probability": 0.95849609375}, {"start": 3399.06, "end": 3399.74, "word": " unknown", "probability": 0.93505859375}], "temperature": 1.0}, {"id": 151, "seek": 343037, "start": 3403.89, "end": 3430.37, "text": "طب ما في عندنا أمراض عديدة بتكون المشكلة موجودة في اللي هو single locus زي cystic fibrosis زي Deutsch-Niemuscular Dystrophy لكن بما يتعلق بالـDiabetes Mellitus هان عندنا المشكلة بتتعلق بـMultiple Genetic Factors", "tokens": [9566, 3555, 19446, 8978, 43242, 8315, 5551, 29973, 46958, 6225, 16254, 41891, 39894, 30544, 9673, 8592, 28820, 3660, 3714, 29245, 23328, 3660, 8978, 13672, 1829, 31439, 2167, 450, 1149, 30767, 1829, 48915, 299, 13116, 2635, 271, 30767, 1829, 12699, 12, 45, 4907, 301, 17792, 31193, 372, 40826, 44381, 4724, 15042, 7251, 2655, 30241, 4587, 20666, 39184, 35, 72, 12632, 376, 898, 30973, 8032, 7649, 43242, 8315, 9673, 8592, 28820, 3660, 39894, 2655, 30241, 4587, 4724, 39184, 44, 723, 647, 306, 3632, 3532, 33375, 830], "avg_logprob": -0.23327205251244937, "compression_ratio": 1.4018691588785046, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 3403.89, "end": 3404.11, "word": "طب", "probability": 0.98291015625}, {"start": 3404.11, "end": 3404.21, "word": " ما", "probability": 0.85791015625}, {"start": 3404.21, "end": 3404.31, "word": " في", "probability": 0.85302734375}, {"start": 3404.31, "end": 3404.59, "word": " عندنا", "probability": 0.594970703125}, {"start": 3404.59, "end": 3405.13, "word": " أمراض", "probability": 0.9358723958333334}, {"start": 3405.13, "end": 3406.13, "word": " عديدة", "probability": 0.9864908854166666}, {"start": 3406.13, "end": 3406.99, "word": " بتكون", "probability": 0.921630859375}, {"start": 3406.99, "end": 3407.79, "word": " المشكلة", "probability": 0.9957275390625}, {"start": 3407.79, "end": 3408.81, "word": " موجودة", "probability": 0.987548828125}, {"start": 3408.81, "end": 3409.53, "word": " في", "probability": 0.9521484375}, {"start": 3409.53, "end": 3409.89, "word": " اللي", "probability": 0.586181640625}, {"start": 3409.89, "end": 3410.17, "word": " هو", "probability": 0.98486328125}, {"start": 3410.17, "end": 3411.07, "word": " single", "probability": 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بالـDiabetes", "probability": 0.761328125}, {"start": 3420.47, "end": 3422.13, "word": " Mellitus", "probability": 0.6062418619791666}, {"start": 3422.13, "end": 3422.99, "word": " هان", "probability": 0.6746826171875}, {"start": 3422.99, "end": 3423.35, "word": " عندنا", "probability": 0.90576171875}, {"start": 3423.35, "end": 3424.45, "word": " المشكلة", "probability": 0.9974365234375}, {"start": 3424.45, "end": 3426.55, "word": " بتتعلق", "probability": 0.972412109375}, {"start": 3426.55, "end": 3428.75, "word": " بـMultiple", "probability": 0.8664143880208334}, {"start": 3428.75, "end": 3429.47, "word": " Genetic", "probability": 0.87939453125}, {"start": 3429.47, "end": 3430.37, "word": " Factors", "probability": 0.938232421875}], "temperature": 1.0}, {"id": 152, "seek": 343971, "start": 3431.53, "end": 3439.71, "text": "وهذه الوضعيات أكتر مجنونة جنوناتيا ومجموعة من الوضعيات الجنوانية تتعامل مع انفلوانات إكسوجينية", "tokens": [2407, 3224, 24192, 2423, 2407, 11242, 3615, 1829, 9307, 5551, 4117, 2655, 2288, 3714, 7435, 1863, 11536, 3660, 10874, 1863, 2407, 8315, 2655, 25528, 4032, 2304, 7435, 2304, 2407, 27884, 9154, 2423, 2407, 11242, 3615, 1829, 9307, 25724, 1863, 2407, 7649, 10632, 6055, 2655, 3615, 10943, 1211, 20449, 16472, 5172, 1211, 2407, 7649, 9307, 11933, 4117, 3794, 29245, 9957, 10632], "avg_logprob": -0.7141393520792977, "compression_ratio": 1.614678899082569, "no_speech_prob": 1.5497207641601562e-06, "words": [{"start": 3431.53, "end": 3432.39, "word": "وهذه", "probability": 0.35614013671875}, {"start": 3432.39, "end": 3432.87, "word": " الوضعيات", "probability": 0.6037190755208334}, {"start": 3432.87, "end": 3433.13, "word": " أكتر", "probability": 0.545745849609375}, {"start": 3433.13, "end": 3433.13, "word": " مجنونة", "probability": 0.411236572265625}, {"start": 3433.13, "end": 3433.57, "word": " جنوناتيا", "probability": 0.5086263020833334}, {"start": 3433.57, "end": 3435.67, "word": " ومجموعة", "probability": 0.5430908203125}, {"start": 3435.67, "end": 3435.81, "word": " من", "probability": 0.68505859375}, {"start": 3435.81, "end": 3435.81, "word": " الوضعيات", "probability": 0.6063435872395834}, {"start": 3435.81, "end": 3436.13, "word": " الجنوانية", "probability": 0.7796875}, {"start": 3436.13, "end": 3437.35, "word": " تتعامل", "probability": 0.79716796875}, {"start": 3437.35, "end": 3437.85, "word": " مع", "probability": 0.923828125}, {"start": 3437.85, "end": 3438.39, "word": " انفلوانات", "probability": 0.512969970703125}, {"start": 3438.39, "end": 3439.71, "word": " إكسوجينية", "probability": 0.53912353515625}], "temperature": 1.0}, {"id": 153, "seek": 346159, "start": 3447.31, "end": 3461.59, "text": "factors وطبعا من هذه الأمراض اللي عندنا multi genetic factors ممكن اللي هو تكون بتلعب دور زي الـ diabetes mellitus زي الـ atherosclerosis، hypertension، osteoporosis", "tokens": [69, 578, 830, 4032, 9566, 3555, 3615, 995, 9154, 29538, 16247, 29973, 46958, 13672, 1829, 43242, 8315, 4825, 12462, 6771, 3714, 43020, 13672, 1829, 31439, 6055, 30544, 39894, 1211, 3615, 3555, 11778, 13063, 30767, 1829, 2423, 39184, 13881, 385, 285, 30973, 30767, 1829, 2423, 39184, 257, 616, 10466, 1918, 8211, 12399, 46172, 12399, 42804, 404, 284, 8211], "avg_logprob": -0.29445042075781985, "compression_ratio": 1.3392857142857142, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 3447.3099999999995, "end": 3448.1099999999997, "word": "factors", "probability": 0.5726725260416666}, {"start": 3448.1099999999997, "end": 3448.91, "word": " وطبعا", "probability": 0.8755859375}, {"start": 3448.91, "end": 3449.03, "word": " من", "probability": 0.93994140625}, {"start": 3449.03, "end": 3449.43, "word": " هذه", "probability": 0.87451171875}, {"start": 3449.43, "end": 3450.51, "word": " الأمراض", "probability": 0.9842122395833334}, {"start": 3450.51, "end": 3451.51, "word": " اللي", "probability": 0.8955078125}, {"start": 3451.51, "end": 3452.21, "word": " عندنا", "probability": 0.55755615234375}, {"start": 3452.21, "end": 3452.83, "word": " multi", "probability": 0.5068359375}, {"start": 3452.83, "end": 3453.15, "word": " genetic", "probability": 0.771484375}, {"start": 3453.15, "end": 3453.55, "word": " factors", "probability": 0.9775390625}, {"start": 3453.55, "end": 3453.99, "word": " ممكن", "probability": 0.941162109375}, {"start": 3453.99, "end": 3454.27, "word": " اللي", "probability": 0.979248046875}, {"start": 3454.27, "end": 3454.35, "word": " هو", "probability": 0.36962890625}, {"start": 3454.35, "end": 3454.57, "word": " تكون", "probability": 0.828369140625}, {"start": 3454.57, "end": 3455.01, "word": " بتلعب", "probability": 0.9520263671875}, {"start": 3455.01, "end": 3455.23, "word": " دور", "probability": 0.994873046875}, {"start": 3455.23, "end": 3455.41, "word": " زي", "probability": 0.91357421875}, {"start": 3455.41, "end": 3455.55, "word": " الـ", "probability": 0.55914306640625}, {"start": 3455.55, "end": 3455.77, "word": " diabetes", "probability": 0.56640625}, {"start": 3455.77, "end": 3456.23, "word": " mellitus", "probability": 0.7921549479166666}, {"start": 3456.23, "end": 3456.47, "word": " زي", "probability": 0.794677734375}, {"start": 3456.47, "end": 3456.63, "word": " الـ", "probability": 0.5450439453125}, {"start": 3456.63, "end": 3458.15, "word": " atherosclerosis،", "probability": 0.8201090494791666}, {"start": 3458.15, "end": 3459.65, "word": " hypertension،", "probability": 0.85107421875}, {"start": 3459.65, "end": 3461.59, "word": " osteoporosis", "probability": 0.857177734375}], "temperature": 1.0}, {"id": 154, "seek": 349270, "start": 3464.4, "end": 3492.7, "text": "طبعًا باستخدام اللي هو طرق مختلفة تم الكشف عن يعني عدد من الجينات اللي لها علاقة بالاصابة بـ Type 2 Diabetes Mellitus وعنا من الدراسات اللي تم استخدامها اللي هو الـ Genome-wide Association Studies وهذا النوع من الدراسات يعني طبعًا إشارة", "tokens": [9566, 3555, 3615, 14111, 995, 4724, 995, 14851, 9778, 3215, 10943, 13672, 1829, 31439, 23032, 2288, 4587, 3714, 46456, 46538, 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3465.84, "end": 3466.22, "word": " طرق", "probability": 0.96142578125}, {"start": 3466.22, "end": 3467.28, "word": " مختلفة", "probability": 0.9945068359375}, {"start": 3467.28, "end": 3467.8, "word": " تم", "probability": 0.93310546875}, {"start": 3467.8, "end": 3468.38, "word": " الكشف", "probability": 0.90185546875}, {"start": 3468.38, "end": 3468.76, "word": " عن", "probability": 0.99658203125}, {"start": 3468.76, "end": 3469.54, "word": " يعني", "probability": 0.94580078125}, {"start": 3469.54, "end": 3470.52, "word": " عدد", "probability": 0.9874674479166666}, {"start": 3470.52, "end": 3472.12, "word": " من", "probability": 0.9892578125}, {"start": 3472.12, "end": 3473.16, "word": " الجينات", "probability": 0.8138427734375}, {"start": 3473.16, "end": 3473.76, "word": " اللي", "probability": 0.991943359375}, {"start": 3473.76, "end": 3474.04, "word": " لها", "probability": 0.6942138671875}, {"start": 3474.04, "end": 3474.54, "word": " علاقة", "probability": 0.9861653645833334}, {"start": 3474.54, "end": 3475.48, "word": " بالاصابة", "probability": 0.84326171875}, {"start": 3475.48, "end": 3475.76, "word": " بـ", "probability": 0.743408203125}, {"start": 3475.76, "end": 3476.04, "word": " Type", "probability": 0.414306640625}, {"start": 3476.04, "end": 3476.22, "word": " 2", "probability": 0.57568359375}, {"start": 3476.22, "end": 3476.54, "word": " Diabetes", "probability": 0.6200358072916666}, {"start": 3476.54, "end": 3477.02, "word": " Mellitus", "probability": 0.775146484375}, {"start": 3477.02, "end": 3478.76, "word": " وعنا", "probability": 0.8097330729166666}, {"start": 3478.76, "end": 3479.36, "word": " من", "probability": 0.99755859375}, {"start": 3479.36, "end": 3481.52, "word": " الدراسات", "probability": 0.9759521484375}, {"start": 3481.52, "end": 3481.74, "word": " اللي", "probability": 0.9921875}, {"start": 3481.74, "end": 3482.3, "word": " تم", "probability": 0.88916015625}, {"start": 3482.3, "end": 3482.86, "word": " استخدامها", "probability": 0.98349609375}, {"start": 3482.86, "end": 3483.0, "word": " اللي", "probability": 0.9228515625}, {"start": 3483.0, "end": 3483.1, "word": " هو", "probability": 0.85009765625}, {"start": 3483.1, "end": 3483.2, "word": " الـ", "probability": 0.6824951171875}, {"start": 3483.2, "end": 3483.6, "word": " Genome", "probability": 0.837646484375}, {"start": 3483.6, "end": 3483.96, "word": "-wide", "probability": 0.54931640625}, {"start": 3483.96, "end": 3484.9, "word": " Association", "probability": 0.82958984375}, {"start": 3484.9, "end": 3486.82, "word": " Studies", "probability": 0.81640625}, {"start": 3486.82, "end": 3488.18, "word": " وهذا", "probability": 0.722412109375}, {"start": 3488.18, "end": 3488.66, "word": " النوع", "probability": 0.9833984375}, {"start": 3488.66, "end": 3489.08, "word": " من", "probability": 0.998046875}, {"start": 3489.08, "end": 3490.34, "word": " الدراسات", "probability": 0.993896484375}, {"start": 3490.34, "end": 3491.16, "word": " يعني", "probability": 0.987060546875}, {"start": 3491.16, "end": 3491.9, "word": " طبعًا", "probability": 0.99228515625}, {"start": 3491.9, "end": 3492.7, "word": " إشارة", "probability": 0.834716796875}], "temperature": 1.0}, {"id": 155, "seek": 350918, "start": 3493.26, "end": 3509.18, "text": "أو كان له دور كبير في ربط العديد من الـ genes بمرض اللي هو الـ type 2 diabetes malatus with more than 60 genetic low key now identified", "tokens": [10721, 2407, 25961, 46740, 11778, 13063, 9122, 3555, 13546, 8978, 12602, 3555, 9566, 18863, 16254, 3215, 9154, 2423, 39184, 14424, 4724, 29973, 11242, 13672, 1829, 31439, 2423, 39184, 2010, 568, 13881, 2806, 37926, 365, 544, 813, 4060, 12462, 2295, 2141, 586, 9234], "avg_logprob": -0.19785610673039458, "compression_ratio": 1.2108843537414966, "no_speech_prob": 0.0, "words": [{"start": 3493.26, "end": 3493.9, "word": "أو", "probability": 0.959716796875}, {"start": 3493.9, "end": 3494.06, "word": " كان", "probability": 0.99072265625}, {"start": 3494.06, "end": 3494.24, "word": " له", "probability": 0.85986328125}, {"start": 3494.24, "end": 3494.46, "word": " دور", "probability": 0.984130859375}, {"start": 3494.46, "end": 3494.92, "word": " كبير", "probability": 0.9943033854166666}, {"start": 3494.92, "end": 3495.36, "word": " في", "probability": 0.96044921875}, {"start": 3495.36, "end": 3496.72, "word": " ربط", "probability": 0.9182942708333334}, {"start": 3496.72, "end": 3498.16, "word": " العديد", "probability": 0.9915364583333334}, {"start": 3498.16, "end": 3498.68, "word": " من", "probability": 0.99755859375}, {"start": 3498.68, "end": 3499.56, "word": " الـ", "probability": 0.792724609375}, {"start": 3499.56, "end": 3500.0, "word": " genes", "probability": 0.415283203125}, {"start": 3500.0, "end": 3501.26, "word": " بمرض", "probability": 0.9894205729166666}, {"start": 3501.26, "end": 3501.44, "word": " اللي", "probability": 0.753662109375}, {"start": 3501.44, "end": 3501.56, "word": " هو", "probability": 0.74853515625}, {"start": 3501.56, "end": 3501.7, "word": " الـ", "probability": 0.72900390625}, {"start": 3501.7, "end": 3501.78, "word": " type", "probability": 0.55859375}, {"start": 3501.78, "end": 3501.98, "word": " 2", "probability": 0.60888671875}, {"start": 3501.98, "end": 3502.48, "word": " diabetes", "probability": 0.78173828125}, {"start": 3502.48, "end": 3503.78, "word": " malatus", "probability": 0.44921875}, {"start": 3503.78, "end": 3504.1, "word": " with", "probability": 0.57177734375}, {"start": 3504.1, "end": 3504.36, "word": " more", "probability": 0.95849609375}, {"start": 3504.36, "end": 3504.58, "word": " than", "probability": 0.9638671875}, {"start": 3504.58, "end": 3505.14, "word": " 60", "probability": 0.685546875}, {"start": 3505.14, "end": 3506.28, "word": " genetic", "probability": 0.69140625}, {"start": 3506.28, "end": 3506.84, "word": " low", "probability": 0.80712890625}, {"start": 3506.84, "end": 3507.12, "word": " key", "probability": 0.76904296875}, {"start": 3507.12, "end": 3507.76, "word": " now", "probability": 0.79345703125}, {"start": 3507.76, "end": 3509.18, "word": " identified", "probability": 0.94482421875}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 3511.368, "duration_after_vad": 3353.6543749999864}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/0H-DC7bobLw_raw.srt b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/0H-DC7bobLw_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..ac4da9185923a515edd01a7499ca2214dc6c063f
--- /dev/null
+++ b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/0H-DC7bobLw_raw.srt
@@ -0,0 +1,2736 @@
+1
+00:00:01,500 --> 00:00:06,520
+بسم الله الرحمن الرحيم، نستكمل مع محاضرة الـ
+
+2
+00:00:06,520 --> 00:00:11,720
+diabetes mellitus clinical utility of measuring
+
+3
+00:00:11,720 --> 00:00:15,600
+insulin, proinsulin, c-peptide and glucagon، يبقى
+
+4
+00:00:15,600 --> 00:00:22,780
+إيش الهدف، إيش الفائدة من قياس هذه ال analytes
+
+5
+00:00:22,780 --> 00:00:28,450
+المختلفة؟طبعا بداية يعني احنا ممكن نتم القياس حسب
+
+6
+00:00:28,450 --> 00:00:38,050
+زي ما هنشوف الأسباب المختلفة لكن يعني مافيش role
+
+7
+00:00:38,050 --> 00:00:43,320
+أو مافيش فائدة من ال routine testingيعني احنا ممكن
+
+8
+00:00:43,320 --> 00:00:48,700
+نقيس و انشخص على سبيل المثال نعمل differential
+
+9
+00:00:48,700 --> 00:00:53,640
+diagnosis بين لو type 1 و type 2 طيب الآن هل يعني
+
+10
+00:00:53,640 --> 00:00:57,700
+نستمر بشكل روتيني بقياس مثلا الـ Insulin أو قياس
+
+11
+00:00:57,700 --> 00:01:01,800
+الـC-peptide؟ لأ، لا يوجد فائدة يبقى ليه الهدف
+
+12
+00:01:01,800 --> 00:01:05,900
+المرجع و بعد هيك يعني لا يوجد داعي ليه الـ routine
+
+13
+00:01:05,900 --> 00:01:14,420
+testing بما تعلق بالإنسولينعنا الأهداف لقياس
+
+14
+00:01:14,420 --> 00:01:19,860
+الإنسلين Evaluation of fasting hypoglycemia بعشان
+
+15
+00:01:19,860 --> 00:01:23,740
+نشوف إيش سبب اللي هو النقص في مستوى الجلوكوز في
+
+16
+00:01:23,740 --> 00:01:29,260
+الدم هل هو زيادة الإنسلين ممكن يكون مثلا وبالتالي
+
+17
+00:01:29,260 --> 00:01:32,160
+بنحتاج إلى قياس مستويات الإنسلين في الدم
+
+18
+00:01:32,160 --> 00:01:39,230
+Evaluation of Polycystic Ovary Syndromeلأن النساء
+
+19
+00:01:39,230 --> 00:01:43,850
+اللي عندهم هذا الـ syndrome بيكون في عندهم insulin
+
+20
+00:01:43,850 --> 00:01:50,430
+resistance وبالتالي من خلال قياس مستوى الـ insulin
+
+21
+00:01:50,430 --> 00:01:56,330
+وقياس ال fasting blood glucose ممكن نحسب ما يسمى
+
+22
+00:01:56,330 --> 00:02:04,790
+بـ HOMA IR واللي من خلاله ممكن نشوف ال insulin
+
+23
+00:02:04,790 --> 00:02:13,340
+resistanceطبعا فيه أنه ال formula لحساب ال home IR
+
+24
+00:02:13,340 --> 00:02:17,900
+زي ما واضحان ال home IR بتسوي لجلوكوز ضرب
+
+25
+00:02:17,900 --> 00:02:23,660
+الإنسولين على أربعمية وخمسة في حال كان إن ال units
+
+26
+00:02:23,660 --> 00:02:28,600
+للي جلوكوز milligram per deciliter أو لجلوكوز ضرب
+
+27
+00:02:28,600 --> 00:02:33,510
+الإنسولينعلى اتنين و عشرين point خمسة في حال كان
+
+28
+00:02:33,510 --> 00:02:39,410
+ال glucose units ال one millimole per literو ال
+
+29
+00:02:39,410 --> 00:02:44,730
+units لأ ال insulin micro units لكل mil طبعا حسب
+
+30
+00:02:44,730 --> 00:02:49,950
+النتيجة اللي بتطلع إذا كان يعني كان الشخص طبيعي
+
+31
+00:02:49,950 --> 00:02:53,530
+وفيش أي insulin resistance بيكون عندنا ال home IR
+
+32
+00:02:53,530 --> 00:02:57,890
+أقل من واحد early insulin resistance إذا كان أكتر
+
+33
+00:02:57,890 --> 00:03:04,490
+من 1.9 و significant insulin resistance إذا ال
+
+34
+00:03:04,490 --> 00:03:07,470
+home IR أكتر من 2.9
+
+35
+00:03:09,520 --> 00:03:13,100
+أيضا ممكن اللي هو نستخدم قياس الانسولين for
+
+36
+00:03:13,100 --> 00:03:16,600
+classification of diabetes mellitus عشان نشوف إيش
+
+37
+00:03:16,600 --> 00:03:22,100
+سبب ارتفاع لي glucose في الدم، هل في عندي absolute
+
+38
+00:03:22,100 --> 00:03:26,760
+deficiency of انسولين أو عندي ممكن اللي هو نقص في
+
+39
+00:03:26,760 --> 00:03:34,430
+الانسولينو بناء عليه يعني ان .. ان .. ان قيم يعني
+
+40
+00:03:34,430 --> 00:03:38,570
+ان .. انحدد ايش نوع ال دهبيروس هل هو type one هل
+
+41
+00:03:38,570 --> 00:03:46,690
+هو type two هل هو modyأيضًا prediction of diabetes
+
+42
+00:03:46,690 --> 00:03:53,070
+mellitus يبقى برضه ممكن يعني يصير اللي هو التوقع
+
+43
+00:03:53,070 --> 00:03:56,570
+أن هذا الشخص ممكن يصاب بـ diabetes mellitus
+
+44
+00:03:56,570 --> 00:04:01,910
+بالمستقبل يعني في حال مثلًا أنه عندنا الـ HOMA IR
+
+45
+00:04:01,910 --> 00:04:06,330
+مثلًا مرتفع وفي عندنا insulin resistance ومعناه في
+
+46
+00:04:06,330 --> 00:04:10,200
+ممكن احتمال أن يصاب هذا الشخص مستقبلاًبالـ
+
+47
+00:04:10,200 --> 00:04:15,160
+diabetes mellitus أيضًا في حالات اللي هو الـ type
+
+48
+00:04:15,160 --> 00:04:21,340
+1 زي ما قلنا أنه بيصير في عنا اللي هو تناقص في الـ
+
+49
+00:04:21,340 --> 00:04:24,100
+ال beta cells وبالتالي في ال concentration
+
+50
+00:04:24,100 --> 00:04:26,480
+للإنسلين
+
+51
+00:04:27,790 --> 00:04:32,790
+assessment of beta cell activity بقى بنقيم عمل الـ
+
+52
+00:04:32,790 --> 00:04:38,090
+beta cells اللي هي المنتجة لهرمون الإنسولين أيضا
+
+53
+00:04:38,090 --> 00:04:41,370
+selection of optimal therapy for diabetes بناء على
+
+54
+00:04:41,370 --> 00:04:45,990
+برضه ال concentration للإنسولين يعني زي في حالات
+
+55
+00:04:45,990 --> 00:04:49,450
+مثلا الـ type 2 diabetes mellitus والحالات
+
+56
+00:04:49,450 --> 00:04:55,450
+المتقدمة يعني من خلال قياسنا للإنسولين بنشوف إذا
+
+57
+00:04:55,450 --> 00:05:02,860
+كانهذا المريض محتاج انه نعطيه exogenous insulin او
+
+58
+00:05:02,860 --> 00:05:10,180
+لأ Invisitation of insulin resistance اللي هو برضه
+
+59
+00:05:10,180 --> 00:05:10,980
+يعني ممكن
+
+60
+00:05:15,190 --> 00:05:19,970
+اللي زي ما شوفنا فيه اللي هو حالة الـ Polycystic
+
+61
+00:05:19,970 --> 00:05:24,610
+Ovary Syndrome اللي من خلال قياسنا لهو ما AIR
+
+62
+00:05:24,610 --> 00:05:28,730
+Prediction of the Development of Coronary Artery
+
+63
+00:05:28,730 --> 00:05:34,450
+Disease لأنه فيه هناعلاقة أكيد بين ال insulin
+
+64
+00:05:34,450 --> 00:05:40,650
+resistance و اللي هو ال atherosclerosis وبالتالي
+
+65
+00:05:40,650 --> 00:05:44,170
+ال coronary artery disease طبعا معاه اللي هو
+
+66
+00:05:44,170 --> 00:05:50,190
+ارتفاع أيضا مستويات الدمونبالنسبة للـ Proinsulin
+
+67
+00:05:50,190 --> 00:05:56,630
+بنستخدمه في الـ diagnosis of beta cell tumors لأن
+
+68
+00:05:56,630 --> 00:06:00,430
+في حالات الـ beta cell tumors في عنا مشكلة في
+
+69
+00:06:00,430 --> 00:06:06,970
+تحويل اللي هو الـ Proinsulin لإنسلين بشكل كامل
+
+70
+00:06:06,970 --> 00:06:09,510
+وبالتالي بيكون في عنا ارتفاع في مستويات الـ
+
+71
+00:06:09,510 --> 00:06:14,350
+Proinsulin أيضًا ليه اللي هو الكشف عن حالات
+
+72
+00:06:14,350 --> 00:06:17,670
+الفميلة الـ hyperproinsulinemia
+
+73
+00:06:18,270 --> 00:06:22,770
+لو بهذه الحالة أيضًاأن ال insulin is not
+
+74
+00:06:22,770 --> 00:06:28,830
+sufficiently processed before secretion تمام؟
+
+75
+00:06:28,830 --> 00:06:31,770
+وبالتالي يعني بيكونش فيه عندنا تحويل بشكل كامل ل
+
+76
+00:06:31,770 --> 00:06:37,270
+.. اللي هو ال pro-insulin إلى insulin وبالتالي
+
+77
+00:06:37,270 --> 00:06:43,330
+بيكون عندنا ال .. الكم الأكبر من ال .. ال insulin
+
+78
+00:06:43,330 --> 00:06:46,810
+الموجود هو immature form of insulin أو اللي هو ال
+
+79
+00:06:46,810 --> 00:06:48,950
+pro-insulin
+
+80
+00:06:53,060 --> 00:07:01,060
+الـ C-peptide مشابه يعني لإيش بنستخدم الـ الانسلين
+
+81
+00:07:01,060 --> 00:07:08,700
+أنه evaluation of fasting hypoglycemia هل المشكلة
+
+82
+00:07:08,700 --> 00:07:13,040
+الـ C اللي هو beta cell ال tumors
+
+83
+00:07:17,470 --> 00:07:23,810
+يبقى بعض المرضى with beta cell اللي هو tumors يعني
+
+84
+00:07:23,810 --> 00:07:29,450
+ممكن لو جينا قصنا مستويات الـ Insulinيعني ما تكونش
+
+85
+00:07:29,450 --> 00:07:34,450
+حاسبة بما يتعلق بيه اللي هو موضوع الـ diagnosis
+
+86
+00:07:34,450 --> 00:07:38,750
+لأنه في عندنا بعض الحالات ممكن يكون الـ
+
+87
+00:07:38,750 --> 00:07:43,490
+hyperinsulinism intermittent يعني مش طول الوقت
+
+88
+00:07:43,490 --> 00:07:48,630
+يعني ممكن يكون بشكل يعني متقطعوبالتالي ممكن لما
+
+89
+00:07:48,630 --> 00:07:51,310
+نيجي نسحب عين أو نقيس اللي هو الـ Insulin مانلاقيش
+
+90
+00:07:51,310 --> 00:07:55,710
+إنه الـ Insulin مرتفع وبالتالي بهذه الحالة ممكن
+
+91
+00:07:55,710 --> 00:07:58,770
+يكون عندنا قياس قياسنا ل الـ C-peptide
+
+92
+00:07:58,770 --> 00:08:06,290
+concentration ممكن يكون مفيد أكتر طبعاً للسبب إنه
+
+93
+00:08:06,290 --> 00:08:10,970
+عندنا ال concentration لـ C-peptide بتكون أعلى بـ
+
+94
+00:08:10,970 --> 00:08:14,890
+5 إلى 10 مرات من الـ Insulin لأنه زي ما حكينا
+
+95
+00:08:14,890 --> 00:08:21,170
+سابقاً أن الـ C-peptidehas a longer half life
+
+96
+00:08:21,170 --> 00:08:25,350
+عندنا أيضًا ممكن يصير فيه اللي هو evaluation
+
+97
+00:08:25,350 --> 00:08:30,450
+لـinfectious اللي
+
+98
+00:08:30,450 --> 00:08:34,910
+هو يكون عندنا fasting hypoglycemia وهذا اللي هو
+
+99
+00:08:34,910 --> 00:08:40,990
+بيكون طبعًا بسبب اللي هو الـexogenous، الانسولين
+
+100
+00:08:40,990 --> 00:08:46,580
+تمام، من خلال القياس اللي هو الـC-peptideيعني ممكن
+
+101
+00:08:46,580 --> 00:08:51,160
+نحدد انه هل ال .. ال .. المشكلة هل ب .. اللي هو ال
+
+102
+00:08:51,160 --> 00:08:56,440
+endogenous insulin أو ب .. المشكلة بال exogenous
+
+103
+00:08:56,440 --> 00:09:01,780
+insulinطبعاً بهذه الحالة هيكون أن الـ Insulin
+
+104
+00:09:01,780 --> 00:09:06,920
+concentration high لكن الـ C-peptide values هتكون
+
+105
+00:09:06,920 --> 00:09:11,060
+low برضه زي ما حكينا أنه يعني ممكن تكون مشيابة
+
+106
+00:09:11,060 --> 00:09:13,860
+لاستخدام ماتنا للإنسلين Classification of diabetes
+
+107
+00:09:13,860 --> 00:09:17,500
+mellitus Assessment of beta cell activity
+
+108
+00:09:17,500 --> 00:09:22,250
+Obtaining insurance coverage for insulin pumpيعني
+
+109
+00:09:22,250 --> 00:09:26,090
+بعض اللي هو شركات التأمين يعني هذا بيكون ممكن في
+
+110
+00:09:26,090 --> 00:09:33,310
+الخارج بعض شركات التأمين بتطلب زي اللي هو دليل على
+
+111
+00:09:33,310 --> 00:09:39,750
+إنه هذا المريض بيحتاج فعليًا إلى صرف insulin pump
+
+112
+00:09:39,750 --> 00:09:44,950
+له وبالتالي بيحتاجوا اللي هو فحص الـ C-peptide
+
+113
+00:09:45,650 --> 00:09:49,630
+أيضًا برضه الـ C-peptide اللي هدور في الـ
+
+114
+00:09:49,630 --> 00:09:54,350
+monitoring of therapy يعني في حالات البنكريكتمي
+
+115
+00:09:54,350 --> 00:09:58,410
+اللي هو لما بيصير في عنا استقصال ليه اللي هو الـ
+
+116
+00:09:58,410 --> 00:10:04,130
+الـ pancreas يعني ممكن نأكد أنه اللي هو استقصال
+
+117
+00:10:04,130 --> 00:10:09,950
+بشكل كامل من خلال اللي هو قياسنا لـ الـ C-peptide
+
+118
+00:10:09,950 --> 00:10:13,190
+تمام؟ يبقى عدا موجود اللي هو الـ C-peptide هذا
+
+119
+00:10:13,190 --> 00:10:18,170
+هيأكد أنه صار هناالموضوع اللي هو الاستقصال بشكل
+
+120
+00:10:18,170 --> 00:10:24,410
+كامل أو في بعض الحالات ممكن تصير فيها اللي هو
+
+121
+00:10:24,410 --> 00:10:29,190
+partial pancreatectomy اللي هو يعني تم استقصال
+
+122
+00:10:29,190 --> 00:10:33,570
+ممكن جزء من اللي هو ال pancreas إذا كان عندنا
+
+123
+00:10:33,570 --> 00:10:38,420
+مشكلة موجودة بال Exocrineالـ glands للبنكرياز
+
+124
+00:10:38,420 --> 00:10:43,900
+وبالتالي يعني ممكن نقيص اللي هو الـ C-peptide عشان
+
+125
+00:10:43,900 --> 00:10:48,060
+نشوف إذا كان البنكرياز يعني مازال قادر ممكن على
+
+126
+00:10:48,060 --> 00:10:53,720
+إنتاج اللي هو الإنسلين أو لأ أيضا بما يتعلق بالـ
+
+127
+00:10:53,720 --> 00:11:00,060
+transplant لل eyelids of longer handsتمامي إذا كان
+
+128
+00:11:00,060 --> 00:11:05,160
+صار فيه عملية تسمى Transplantation ل Islets of
+
+129
+00:11:05,160 --> 00:11:10,360
+longer hands عشان نشوف إذا كان هذه ال islets يعني
+
+130
+00:11:10,360 --> 00:11:18,500
+أخدت مكانها و بدت تنتج ال insulin أو لأ برضه بما
+
+131
+00:11:18,500 --> 00:11:24,060
+يتعلق بال monitoring therapy و ال immunomodulation
+
+132
+00:11:24,060 --> 00:11:31,040
+of type 1وفي الـ Immunomodulation يعني ممكن تعتبر
+
+133
+00:11:31,040 --> 00:11:41,960
+part of immunotherapy للأشخاص ممكن اللي يعني عندهم
+
+134
+00:11:41,960 --> 00:11:45,440
+اللي وطيب و عنده beta smaletas أو تم اكتشاف ممكن
+
+135
+00:11:45,440 --> 00:11:49,400
+المرض عندهم اللي وطيب و عنده beta smaletas لكن
+
+136
+00:11:49,400 --> 00:11:55,950
+يعني ما زال عندناالـ Beta cells ممكن يعني يتم
+
+137
+00:11:55,950 --> 00:12:05,350
+استرجاع جزء منها وبالتالي يعني بيتم اللي هو يعني
+
+138
+00:12:05,350 --> 00:12:12,810
+زي تثبيت لجهاز المناعةوبالتالي يعني عشان نحافظ
+
+139
+00:12:12,810 --> 00:12:19,010
+ممكن على اللي المتبقي من الـ Beta-cells اللي
+
+140
+00:12:19,010 --> 00:12:23,590
+موجودة وبالتالي بنقيص برضه الـC-peptide عشان نشوف
+
+141
+00:12:23,590 --> 00:12:32,090
+هل الـimmune modulation يعني في استجابة أو لأعنده
+
+142
+00:12:32,090 --> 00:12:36,070
+أيضًا الـ glucagon من الفحصات اللي بيتتم وهذا
+
+143
+00:12:36,070 --> 00:12:41,910
+بيستخدم لل diagnosis of alpha cell tumors
+
+144
+00:12:41,910 --> 00:12:45,350
+pathogenesis
+
+145
+00:12:45,350 --> 00:12:54,020
+of type 1 diabetes mellitus حكينا سابقًا أنهالسبب
+
+146
+00:12:54,020 --> 00:12:59,900
+ليحدوث الـ Type 1 diabetes mellitus ممكن يكون بسبب
+
+147
+00:12:59,900 --> 00:13:03,740
+اللي هو الـ autoimmune destruction of beta cells
+
+148
+00:13:03,740 --> 00:13:11,500
+وطبعاً السبب هذا اللي هو بيمثل يعني الجزء الأكبر
+
+149
+00:13:11,500 --> 00:13:17,380
+من الإصابات بالـ Type 1 وعنا الجزء الآخر اللي هو
+
+150
+00:13:17,380 --> 00:13:20,440
+بيكون السبب غير معروف اللي هو الـ idiopathic
+
+151
+00:13:22,670 --> 00:13:25,270
+الـ in the vast majority of patients destruction
+
+152
+00:13:25,270 --> 00:13:31,910
+is mediated by T cells وهذا النوع اللي هو المسئول
+
+153
+00:13:31,910 --> 00:13:36,890
+عنه الـ autoimmune destruction بنطلق عليه أيضًا
+
+154
+00:13:36,890 --> 00:13:45,470
+type 1a أو immune mediated diabetes الآن الخلايا
+
+155
+00:13:45,470 --> 00:13:51,500
+اللي فعليًا بيهاجمة جهاز المناعة هوخلايا الـ Beta
+
+156
+00:13:51,500 --> 00:13:56,040
+-cells بدون ما يكون فيه أي تأثير على الـ Alpha
+
+157
+00:13:56,040 --> 00:13:59,880
+-cells أو الـ Delta-cells يبقى الـ Alpha و الـ
+
+158
+00:13:59,880 --> 00:14:04,260
+Delta-cells are preserved بتم اللي هو المحافظة
+
+159
+00:14:04,260 --> 00:14:10,040
+عليهم The islet cells have a chronic mononuclear
+
+160
+00:14:10,040 --> 00:14:15,560
+cell infiltrate يبقى بيصير فيه عندناinfiltration
+
+161
+00:14:15,560 --> 00:14:19,800
+اللي هو lymphocytic infiltration لالـ islets of
+
+162
+00:14:19,800 --> 00:14:24,840
+Langerhans وهذه اللي هو بيطلق عليها enceolitis
+
+163
+00:14:24,840 --> 00:14:28,740
+اللي هو inflammation of the islets of Langerhans
+
+164
+00:14:28,740 --> 00:14:32,580
+وزي ما قلنا بيحصل فيها اللي هو lymphocytic
+
+165
+00:14:32,580 --> 00:14:34,180
+infiltration
+
+166
+00:14:36,990 --> 00:14:43,570
+الـ Autoimmune Destruction الـ process اللي هتقدي
+
+167
+00:14:43,570 --> 00:14:46,810
+إلى طبعا Destruction of Beta Cells وبالتالي الـ
+
+168
+00:14:46,810 --> 00:14:52,710
+Type I ده Beta Smaletas المدة اللي هتاخدها بتختلف
+
+169
+00:14:52,710 --> 00:14:58,810
+يعني من month ل years وهذا يعني مرتبط ممكن بأسباب
+
+170
+00:14:58,810 --> 00:15:07,890
+مختلفة ممكن منها عمر الشخص المصابالآن الـ ال
+
+171
+00:15:07,890 --> 00:15:12,410
+clinical presentations فعليًا و ال diagnosis ممكن
+
+172
+00:15:12,410 --> 00:15:18,370
+أو ال symptoms ممكن تظهر لما يصير فيه أن 80 إلى 90
+
+173
+00:15:18,370 --> 00:15:26,650
+بالمية من ال beta cells يعني بالفعل صار ناقص فيها
+
+174
+00:15:29,000 --> 00:15:32,360
+رقم اتفاق الأطفال للتدمير البيتا هي مختلفة وعادة
+
+175
+00:15:32,360 --> 00:15:37,840
+أسرع في الأطفال من الأطفال اللي كمان اللي هو زي ما
+
+176
+00:15:37,840 --> 00:15:42,980
+قلنا العمر بيفرق وعنا ال destruction ل ال beta
+
+177
+00:15:42,980 --> 00:15:51,360
+cells هذي بيكون أسرع عند الأطفال في حالة اللي هو
+
+178
+00:15:51,360 --> 00:15:55,920
+ال autoimmune destruction ل ال beta cellsبيتم
+
+179
+00:15:55,920 --> 00:15:59,680
+إنتاج العديد من الـ antibodies
+
+180
+00:16:02,580 --> 00:16:07,080
+وممكن من خلال الكشف عن هذه الـ Antibodies تتم
+
+181
+00:16:07,080 --> 00:16:14,400
+تأكيد الإصابة بالـ Type 1 Diabetes Mellitus وهذه
+
+182
+00:16:14,400 --> 00:16:19,240
+الـ Antibodies ممكن يصلها Detection في الـ Serum
+
+183
+00:16:19,240 --> 00:16:24,080
+لإيه ال patients years before the onset of
+
+184
+00:16:24,080 --> 00:16:29,520
+hyperglycemia لأن حلولنا ممكن موضوعالـ ال
+
+185
+00:16:29,520 --> 00:16:32,580
+destruction ياخد سنوات وبالتالي هيكون فيها عندنا
+
+186
+00:16:32,580 --> 00:16:37,060
+موجود antibodies لو يعني تم الكشف عن هذه ال
+
+187
+00:16:37,060 --> 00:16:42,220
+antibodies بيه ال patients serumمن الـ Antibodies
+
+188
+00:16:42,220 --> 00:16:47,140
+اللي بتكون موجودة في حالات الـ Type 1 diabetes
+
+189
+00:16:47,140 --> 00:16:51,640
+mellitus فينا القارة Cell Cytoplasmic Antibodies
+
+190
+00:16:51,640 --> 00:17:01,100
+وهذه الـ Antibodies بتنتج ضد أنتجينيسمى سيالو
+
+191
+00:17:01,100 --> 00:17:05,460
+إيجلوكو كونجيجيت أنتيجن وهذا الانتيجن موجود
+
+192
+00:17:05,460 --> 00:17:09,360
+بالـCytoplasm of all endocrine cells of the
+
+193
+00:17:09,360 --> 00:17:14,120
+pancreatic eyelids. These antibodies are detected
+
+194
+00:17:14,120 --> 00:17:17,480
+in the serum of 0.5% of normal subjects، بما يمكن
+
+195
+00:17:17,480 --> 00:17:21,160
+أن الـantibodies هذه كمان اللي جيها عند نسبة قليلة
+
+196
+00:17:21,160 --> 00:17:26,800
+من الأشخاص السالمين، اللي هي تقريبا عن 0.5%of
+
+197
+00:17:26,800 --> 00:17:32,100
+normal subjects لكن أكيد بتكون موجودة بيه عند
+
+198
+00:17:32,100 --> 00:17:34,640
+الأشخاص المصابين بالـ Type 1 diabetes mellitus
+
+199
+00:17:34,640 --> 00:17:40,620
+اللي هو 75% إلى 85% of patients with a newly
+
+200
+00:17:40,620 --> 00:17:43,920
+diagnosed Type 1 diabetes mellitus have eyelid
+
+201
+00:17:43,920 --> 00:17:50,320
+cell cytoplasmic antibodies عندنا
+
+202
+00:17:50,320 --> 00:17:54,890
+antibody آخر برضه ممكن يكون موجودانشلين O2
+
+203
+00:17:54,890 --> 00:18:00,390
+Antibodies وهذا موجود بنسبة عالية من الأطفال
+
+204
+00:18:00,390 --> 00:18:02,530
+المصابين بالـ Type 1 Diabetes Mellitus اللي هو
+
+205
+00:18:02,530 --> 00:18:08,950
+موجود في أكتر من 90% من الأطفال اللي عندهم Type 1
+
+206
+00:18:08,950 --> 00:18:15,830
+Diabetes Mellitus يا بالسن الخامسة لكن نسبة الـ
+
+207
+00:18:15,830 --> 00:18:21,170
+Antibodies هذه بتقل له بعد سن الخامسة
+
+208
+00:18:23,340 --> 00:18:28,700
+يبقى الحالات اللي فوق سن الـ 12 بتلاقي أنه هذه الـ
+
+209
+00:18:28,700 --> 00:18:34,140
+Antibodies موجودة بيه اللي هو تقريبا عند 40% أو
+
+210
+00:18:34,140 --> 00:18:40,120
+أقل من هدول الأشخاص الـ Antibodies هذه برضه ممكن
+
+211
+00:18:40,120 --> 00:18:43,220
+تصل إلى detection عند الأشخاص السالمين برضه
+
+212
+00:18:43,220 --> 00:18:50,260
+بالنسبة قليلة لـ 0.5%ممكن أيضًا تتم الكشف عن
+
+213
+00:18:50,260 --> 00:18:56,800
+antibodies لـ 65-kD-isoform of glutamic acid D
+
+214
+00:18:56,800 --> 00:19:00,040
+-carboxylase الوالجاد 65
+
+215
+00:19:02,470 --> 00:19:06,110
+واحنا قلنا إنه ممكن يتم الكشف عن الـ Antibodies
+
+216
+00:19:06,110 --> 00:19:11,710
+اللي هو السنوات قبل ما فعلياً يتم عملية الـ
+
+217
+00:19:11,710 --> 00:19:15,710
+diagnosis لشخص with type 1 diabetes مليتاس وعنا
+
+218
+00:19:15,710 --> 00:19:22,790
+تقريباً ممكن يتم الكشف عن أو ال detection للـ
+
+219
+00:19:22,790 --> 00:19:25,090
+antibodies اللي هو against glutamic acid
+
+220
+00:19:25,090 --> 00:19:28,750
+decarboxylase 10 years before the onset of a
+
+221
+00:19:28,750 --> 00:19:33,020
+clinical type 1 diabetesمالليتاس وهذه الـ
+
+222
+00:19:33,020 --> 00:19:37,980
+antibodies موجودة عن 60% من ال patients within you
+
+223
+00:19:37,980 --> 00:19:44,280
+اللي diagnosed type 1 diabetes مالليتاس في أن بعض
+
+224
+00:19:44,280 --> 00:19:49,160
+الحالات اللي ممكن يعني تشخص بداية على إنها type 2
+
+225
+00:19:49,160 --> 00:19:50,360
+diabetes مالليتاس
+
+226
+00:19:53,000 --> 00:19:56,220
+اللي هو apparently يعني type 2 diabetes mellitus
+
+227
+00:19:56,220 --> 00:20:05,920
+لكن إذا تم اللي هو الفحص الجاد 65 antibodies وطبعا
+
+228
+00:20:05,920 --> 00:20:11,080
+تم الكشف عن هذه ال antibodies عند هذا اللي هو ال
+
+229
+00:20:11,080 --> 00:20:15,620
+patient إيه بمعناته ال diagnosis الصحيح هيكون اللي
+
+230
+00:20:15,620 --> 00:20:17,220
+هو type 1 diabetes
+
+231
+00:20:24,180 --> 00:20:31,160
+اللي زي ما قلنا لو يعني بعد فترة من الزمن هلاجي
+
+232
+00:20:31,160 --> 00:20:36,680
+أنه هذا الشخص فعليا اللي هو عنده type 1 diabetes
+
+233
+00:20:36,680 --> 00:20:45,610
+mellitus ومش type 2ذكرنا سابقاً إنه الـtype 2
+
+234
+00:20:45,610 --> 00:20:48,670
+diabetes mellitus patients يعني ممكن في مراحل
+
+235
+00:20:48,670 --> 00:20:54,490
+متقدمة يعني بيصبحوا يعتمدوا على الـexogenous
+
+236
+00:20:54,490 --> 00:20:59,990
+انسلين لكن في بعض الحالات اللي هو الـtype 2
+
+237
+00:20:59,990 --> 00:21:06,430
+diabetes mellitusممكن الـ progression لـ الـ
+
+238
+00:21:06,430 --> 00:21:13,450
+disease تكون سريعة يعني ومايحتاجوش مدة طويلة عشان
+
+239
+00:21:13,450 --> 00:21:19,070
+اللي هو يحتاجوا إلى exogenous insulin الآن ممكن
+
+240
+00:21:19,070 --> 00:21:23,450
+نكشف عن هدول الفئة من المرضى اللي هو عندهم type 2
+
+241
+00:21:23,450 --> 00:21:30,410
+diabetes mellitusلكن ممكن يعني يصير اللي هو
+
+242
+00:21:30,410 --> 00:21:36,610
+deficiency للإنسلين مستقبلا من خلال فحصنا للـ
+
+243
+00:21:36,610 --> 00:21:41,410
+GAD65 Antibodies يبقى الـType-2 Diabetes مليتها ال
+
+244
+00:21:41,410 --> 00:21:45,010
+patients اللي بنكشف عن وجود اللي هو الـ GAD65
+
+245
+00:21:45,010 --> 00:21:48,230
+Antibodies عندهم يبقى هدول ممكن يصير في عنا
+
+246
+00:21:48,230 --> 00:21:53,590
+progression بشكل سريع
+
+247
+00:21:54,610 --> 00:22:01,010
+ويتحولوا إلى طبعا الاعتماد على الانسلين بشكل كامل
+
+248
+00:22:01,010 --> 00:22:06,510
+عندنا أيضا Antibodies اللي بيفرزوا against
+
+249
+00:22:06,510 --> 00:22:12,410
+insulinoma associated antigens اللي IA to A و IA
+
+250
+00:22:12,410 --> 00:22:18,250
+to Beta A هدول الانتيجين هم عبارة عن Transmembrane
+
+251
+00:22:18,250 --> 00:22:23,030
+proteins of dead core vesicles
+
+252
+00:22:25,360 --> 00:22:32,060
+الآن لما بيصير فينا مهاجمة لهذه الـ antigens من
+
+253
+00:22:32,060 --> 00:22:38,660
+خلال ال antibodies اللي بتتكون ضدهم هذا بيؤدي إلى
+
+254
+00:22:39,840 --> 00:22:45,560
+تقليل عدد اللي هو الـ dense core vesicles اللي هي
+
+255
+00:22:45,560 --> 00:22:50,300
+اللي بتحتوي على هرمونات وبهذه الحالة مازال بنحكي
+
+256
+00:22:50,300 --> 00:22:54,540
+على الـ islands of Langerhans وبنحكي على هرمونات
+
+257
+00:22:54,540 --> 00:23:00,040
+زي اللي هو الانسولين في الـ beta cells يعني الـ
+
+258
+00:23:00,040 --> 00:23:04,600
+antibodies اللي بتفرز ضد هذه الـ antigens بتقلل من
+
+259
+00:23:04,600 --> 00:23:10,980
+الـ dense core vesiclesوبالتالي بتقلل من ال
+
+260
+00:23:10,980 --> 00:23:17,640
+secretion of insulin hormones هذه ال antibodies
+
+261
+00:23:17,640 --> 00:23:21,140
+have been detected in more than 50% of newly
+
+262
+00:23:21,140 --> 00:23:26,980
+diagnosed type 1 diabetes mellitus patients عندنا
+
+263
+00:23:26,980 --> 00:23:32,680
+أيضا antibodies أخرى اللي هي بتنتج against the
+
+264
+00:23:32,680 --> 00:23:38,580
+zinc transporterاللي عبارة عن Transmembrane، a
+
+265
+00:23:38,580 --> 00:23:44,420
+protein responsible for the influx of zinc and
+
+266
+00:23:44,420 --> 00:23:51,300
+other ions Was
+
+267
+00:23:51,300 --> 00:23:55,840
+identified in 2007 as a major auto-antigen in type
+
+268
+00:23:55,840 --> 00:23:57,880
+1 diabetes mellitus
+
+269
+00:24:00,080 --> 00:24:05,160
+الأقل مميزًا من الانتباطات الـ O2 في الديابتس يعني
+
+270
+00:24:05,160 --> 00:24:10,380
+بيحتاج إلى ممكن أكتر عملية تحقيقها بشكل مفهوم
+
+271
+00:24:13,810 --> 00:24:19,890
+60% من الحالات اللي بتتم اكتشافها من اللي هو الـ
+
+272
+00:24:19,890 --> 00:24:26,770
+Type 1 diabetes mellitus بنلاقي أنه فيه اللي هو
+
+273
+00:24:26,770 --> 00:24:33,970
+antibodies ضد الـ Zinc الـ Transporterطبعاً مقارنة
+
+274
+00:24:33,970 --> 00:24:39,950
+بأقل من 2% عند الـ Controls أو اللي هو 3% عند
+
+275
+00:24:39,950 --> 00:24:43,950
+الأشخاص المصابين بالـ Type 2 Diabetes Mellitus
+
+276
+00:24:43,950 --> 00:24:49,890
+بنسبة عالية اللي هو 60 إلى 80% من ال patients with
+
+277
+00:24:49,890 --> 00:24:55,070
+Type 1 Diabetes Mellitus بنلاقي اللي هو عندهم هذا
+
+278
+00:24:55,070 --> 00:25:01,080
+الـ Auto Antigenأكثر مهمات الانتيبادات لـ Zinc
+
+279
+00:25:01,080 --> 00:25:06,740
+Transporter تتم إتجارها في حوالي 26% من المستخدمين
+
+280
+00:25:06,740 --> 00:25:09,460
+لـ Type 1 Diabetes Mellitus اللي هم نقاط مفارقة
+
+281
+00:25:09,460 --> 00:25:14,300
+لعائلة أخرى أوتو انتيبادات الانتيبادات اللي
+
+282
+00:25:14,300 --> 00:25:20,200
+ذكرناها سابقا ممكن نلاقي أن شخص عنده Type 1
+
+283
+00:25:20,200 --> 00:25:24,450
+Diabetes Mellitusو negative لل auto antibodies
+
+284
+00:25:24,450 --> 00:25:30,910
+الأخرى كلها لكن يكون positive للوزينك transporter
+
+285
+00:25:30,910 --> 00:25:32,270
+antibodies
+
+286
+00:25:36,200 --> 00:25:41,300
+طبعًا ممكن نكشف عن هذه الـ Antibodies المختلفة
+
+287
+00:25:41,300 --> 00:25:45,940
+باستخدام الـ Radio Immunoassay باستخدام الـ ELISA
+
+288
+00:25:45,940 --> 00:25:51,280
+وفي إن له تكنيك جديد يسمى Plasmonic Chip Based
+
+289
+00:25:51,280 --> 00:25:56,980
+Assay برضه ممكن يستخدم للكشف عن الـ Antibodies
+
+290
+00:25:56,980 --> 00:25:58,620
+المختلفة
+
+291
+00:26:00,600 --> 00:26:04,400
+بما يتعلق بالـ Genetics و الـ Type 1 diabetes
+
+292
+00:26:04,400 --> 00:26:12,220
+mellitus الـ Genetics يعني ابتلاعب ممكن دور أقل بـ
+
+293
+00:26:12,220 --> 00:26:17,580
+الـ Type 1 diabetes mellitus إذا ما تم مقالة الأمر
+
+294
+00:26:17,580 --> 00:26:20,320
+بـ الـ Type 2 diabetes mellitus
+
+295
+00:26:22,350 --> 00:26:24,850
+الـ susceptibility to type 1 diabetes mellitus is
+
+296
+00:26:24,850 --> 00:26:27,390
+inherited but the mode of inheritance is complex
+
+297
+00:26:27,390 --> 00:26:31,730
+and has not been identified، يعني لسه بنحتاج more
+
+298
+00:26:31,730 --> 00:26:37,010
+research عشان نفهم أكتر علاقة ال genetics بالـ
+
+299
+00:26:37,010 --> 00:26:40,890
+type 1 diabetes mellitus، it is a multi-genetic
+
+300
+00:26:40,890 --> 00:26:46,170
+trait، يعني أن أكتر من جين اللي هم علاقة بتكون
+
+301
+00:26:46,720 --> 00:26:50,940
+البرط And the major locus is the major
+
+302
+00:26:50,940 --> 00:26:56,740
+histocompatibility complex on chromosome 6 إن
+
+303
+00:26:56,740 --> 00:27:05,700
+أيضًا 11 موقع آخر على 9 كروموزومات برضه بيلعب دور
+
+304
+00:27:05,700 --> 00:27:16,510
+ويعني مرتبط بالـ regulatory region للإنسلين جينالـ
+
+305
+00:27:16,510 --> 00:27:16,750
+Human Leukocyte Antigen HLA-DQ-DR الهيومان
+
+306
+00:27:16,750 --> 00:27:22,050
+ليكوسايت انتيجين HLA-DQ-DR الهيومان ليكوسايت
+
+307
+00:27:22,050 --> 00:27:22,050
+انتيجين HLA-DQ-DR الهيومان ليكوسايت انتيجين HLA-DQ
+
+308
+00:27:22,050 --> 00:27:22,070
+-DR الهيومان ليكوسايت انتيجين HLA-DQ-DR الهيومان
+
+309
+00:27:22,070 --> 00:27:22,950
+ليكوسايت انتيجين HLA-DQ-DR الهيومان ليكوسايت
+
+310
+00:27:22,950 --> 00:27:27,310
+انتيجين HLA-DQ-DR الهيومان ليكوسايت انتيجين HLA-DQ
+
+311
+00:27:27,310 --> 00:27:34,870
+-DR الهيومان ليكوسايت انتيجين HLA-DQ-DR الهيومان
+
+312
+00:27:34,870 --> 00:27:39,430
+ليكوسايت انتيجين HLA-DQ-DR الهيومان ليكوسايت
+
+313
+00:27:39,430 --> 00:27:45,160
+انتيجين HLA-DQبما يتعلق بالـ Concordance Rate بين
+
+314
+00:27:45,160 --> 00:27:53,840
+Identical Twins اللي هو تقريبًا 30% فقط يعني عند
+
+315
+00:27:53,840 --> 00:27:59,640
+الـ Identical Twins ممكن إذا عند 30% من الأشخاص
+
+316
+00:27:59,640 --> 00:28:02,240
+اللي هو Identical Twins إذا واحد عنده Type 1
+
+317
+00:28:02,240 --> 00:28:07,240
+Diabetes الآخر هيكون أو هيصاب بـType 1 Diabetes
+
+318
+00:28:07,240 --> 00:28:08,220
+Malatus
+
+319
+00:28:11,080 --> 00:28:15,340
+10 بالمية of patients with type 1 diabetes
+
+320
+00:28:15,340 --> 00:28:19,360
+mellitus have an affected first degree relative
+
+321
+00:28:19,360 --> 00:28:27,520
+وعنا برضه مواقع أخرى اللي غير الـ HLA اللي هو
+
+322
+00:28:27,520 --> 00:28:32,320
+تقريباً 40 جين
+
+323
+00:28:32,320 --> 00:28:39,440
+هدول برضه لجوا إن فيه لهمعلاقة لكن these have a
+
+324
+00:28:39,440 --> 00:28:44,800
+smaller effects التأثير يعني أقل إذا ما كورن
+
+325
+00:28:44,800 --> 00:28:48,220
+بالتأثير ل ال HLA
+
+326
+00:28:50,900 --> 00:28:56,700
+يعني زي ما شفنا إنه في عندنا ممكن يعني Genes
+
+327
+00:28:56,700 --> 00:29:01,820
+مختلفة وعديدة اللي بتلعب دور ممكن بالإصابة بـType
+
+328
+00:29:01,820 --> 00:29:08,560
+I Diabetes Mellitus وهذا برشح إنه Genات أكتر ممكن
+
+329
+00:29:08,560 --> 00:29:14,320
+يتم التعرف عليها مستقبلاً وبرضه يربطوها بـType I
+
+330
+00:29:14,320 --> 00:29:21,030
+Diabetes Mellitusبما يتعلق بالـ Measurement أو الـ
+
+331
+00:29:21,030 --> 00:29:26,810
+Detection of Genetic Markers هل مفيدة بالمرحلة
+
+332
+00:29:26,810 --> 00:29:30,630
+الحالية الـ Routine Measurement of Genetic Markers
+
+333
+00:29:30,630 --> 00:29:35,490
+is not of value at this time for the diagnosis or
+
+334
+00:29:35,490 --> 00:29:38,850
+management of patients with type 1 diabetes
+
+335
+00:29:38,850 --> 00:29:43,360
+mellitusولا يعني لأ إلها فائدة في الـ diagnosis
+
+336
+00:29:43,360 --> 00:29:50,300
+ولا إلها فائدة أيضًا في الـ management أو في إدارة
+
+337
+00:29:50,300 --> 00:29:56,620
+المرضى من ناحية أخرى ال environment برضه والعوامل
+
+338
+00:29:56,620 --> 00:30:02,500
+البيئية طبعًا مع وجود اللي هو الـ genetic
+
+339
+00:30:02,500 --> 00:30:06,820
+predisposition العوامل البيئية برضه بتلعب دور في
+
+340
+00:30:06,820 --> 00:30:13,440
+الإصابةمقالات يبقى تسمح بأن مصادر البيئة مهتمين
+
+341
+00:30:13,440 --> 00:30:18,680
+بالتقديم للديابتسومن هذه الـ Environmental Factors
+
+342
+00:30:18,680 --> 00:30:23,860
+في عندنا Viruses في عندنا اللي ممكن بعض ال
+
+343
+00:30:23,860 --> 00:30:30,940
+Chemicals ممكن ال .. ال .. ال food يعني العوامل
+
+344
+00:30:30,940 --> 00:30:34,960
+المختلفة هذه ممكن تلعب دور ال viruses زي اللي
+
+345
+00:30:34,960 --> 00:30:39,600
+روبيلا .. روبيلا مامس Indirovirus كوكساكي virus
+
+346
+00:30:39,600 --> 00:30:42,600
+بيه have been implicated
+
+347
+00:30:45,160 --> 00:30:54,040
+والإصابة ببعض الفيروسات مرتبط بوجود شبه بين Viral
+
+348
+00:30:54,040 --> 00:31:02,180
+Protein مع Beta Cell Protein يبقى الـ Viral
+
+349
+00:31:02,180 --> 00:31:05,180
+Protein shares amino acid sequence with a Beta
+
+350
+00:31:05,180 --> 00:31:10,280
+Cell Protein لما يوم بتاع الإصابة في هذه الفيروسات
+
+351
+00:31:10,280 --> 00:31:12,320
+ممكن يعني
+
+352
+00:31:15,000 --> 00:31:19,280
+يفعل أو can initiate اللي هو immune response
+
+353
+00:31:19,280 --> 00:31:25,430
+against the beta cellsزي ما قلنا إنه الـ Genetic
+
+354
+00:31:25,430 --> 00:31:30,310
+Factors وجود الـ Genetic Factors بتخلي الشخص يعني
+
+355
+00:31:30,310 --> 00:31:35,990
+more susceptible زي اللي هو الـ HLA-type عند
+
+356
+00:31:35,990 --> 00:31:40,770
+المريض وبالتالي بتحدد يعني الـ Genetic Factors مع
+
+357
+00:31:40,770 --> 00:31:43,770
+وجود له الـ Environmental Factors determine the
+
+358
+00:31:43,770 --> 00:31:49,390
+progression of the Beta Cell destructionأيضًا زي
+
+359
+00:31:49,390 --> 00:31:53,290
+ما قلنا إنه ممكن بعض الأطعمة أو ممكن تلعب دور
+
+360
+00:31:53,290 --> 00:31:56,770
+وخاصة عند الأطفال يعني في عندنا من خلال الـ
+
+361
+00:31:56,770 --> 00:32:01,970
+Epidemiological studies they have implicated early
+
+362
+00:32:01,970 --> 00:32:05,470
+exposure to cow's milk as a trigger of type 1
+
+363
+00:32:05,470 --> 00:32:10,950
+diabetes mellitus يبقى الأطفال إذا كان بيتم
+
+364
+00:32:10,950 --> 00:32:16,990
+إعطائهم الوردع واللي هو يعني قبل ما يصل هذا الطفل
+
+365
+00:32:16,990 --> 00:32:26,400
+عمره السنةإذا كان بيتم إعطائهم حليب بقر لجوا إنه
+
+366
+00:32:26,400 --> 00:32:30,300
+هدول الأطفال ممكن يصابوا مستقبلا بـ Type 1
+
+367
+00:32:30,300 --> 00:32:34,780
+diabetes mellitus طبعا الأطفال اللي عندهم يعني
+
+368
+00:32:34,780 --> 00:32:40,440
+بتكون لسه مش fully mature وبالتالي ممكن يصير في
+
+369
+00:32:40,440 --> 00:32:46,810
+عنا absorption لبعضممكن المكونات اللي المفروض ما
+
+370
+00:32:46,810 --> 00:32:50,350
+يمثلهاش absorption وبتالي ممكن هذي يتشكل اللي هو
+
+371
+00:32:50,350 --> 00:32:55,430
+ال trigger للإصابة بيقل type 1 diabetes mellitus
+
+372
+00:32:55,430 --> 00:33:00,270
+this model is argumentative and has been debated
+
+373
+00:33:00,270 --> 00:33:06,710
+for decades بيبقى لسه فيش فعليا يعني إجماع على
+
+374
+00:33:06,710 --> 00:33:13,370
+اللي هو فكرة اللي هو ال cows milk وفييعني خلاف
+
+375
+00:33:13,370 --> 00:33:20,990
+وجدال كبير بما يتعلق بهذا الأمر طيب
+
+376
+00:33:20,990 --> 00:33:23,670
+بما يتعلق بالـ pathogenesis of type 2 diabetes
+
+377
+00:33:23,670 --> 00:33:32,860
+mellitus في عندنا مشكلتين اللي هو أساسيتينالمشكلة
+
+378
+00:33:32,860 --> 00:33:36,940
+الأولى هي الـ Insulin resistance اللي هو عدم
+
+379
+00:33:36,940 --> 00:33:41,580
+استجابة الخلايا للإنسلين بالشكل المطلوب Decreased
+
+380
+00:33:41,580 --> 00:33:46,560
+ability of insulin to act on peripheral tissue It
+
+381
+00:33:46,560 --> 00:33:49,300
+is thought by many to be the primary underlying
+
+382
+00:33:49,300 --> 00:33:55,200
+pathological process وهي هذه المشكلة الأساسية
+
+383
+00:33:56,680 --> 00:34:01,100
+والمشكلة التانية Beta cell dysfunction in ability
+
+384
+00:34:01,100 --> 00:34:04,660
+of the pancreas to produce sufficient insulin to
+
+385
+00:34:04,660 --> 00:34:09,440
+compensate for the insulin resistance بعدم مقدرة
+
+386
+00:34:09,440 --> 00:34:13,980
+البنكرياز على التعامل مع المشكلة القائمة اللي هي
+
+387
+00:34:13,980 --> 00:34:17,780
+يقولنا المشكلة الأساسية وهيالـ Insulin resistance
+
+388
+00:34:17,780 --> 00:34:23,320
+و اللي هو الزيادة في ال secretion للإنسلين عشان
+
+389
+00:34:23,320 --> 00:34:30,160
+انعود ال insulin resistance اللي صار.يبقى المريض
+
+390
+00:34:30,160 --> 00:34:38,880
+بداية بيبدأ ب relative deficiency of insulinتمام،
+
+391
+00:34:38,880 --> 00:34:42,180
+لأنه زي ما قلنا بيبدأ يصير في عنا Beta cell
+
+392
+00:34:42,180 --> 00:34:47,080
+dysfunction وفي الحالات المتقدمة من الـ Type 2
+
+393
+00:34:47,080 --> 00:34:50,840
+diabetes mellitus ممكن اللي هو ينتهي الشخص بـ
+
+394
+00:34:50,840 --> 00:34:55,600
+Absolute deficiency ويصير اللي هو بيعتمد على
+
+395
+00:34:55,600 --> 00:34:59,600
+الإنسلين كعلاج بشكل أساسي
+
+396
+00:35:02,050 --> 00:35:07,070
+فيه hand في هذه اللي هو النقطة جدال اللي هو الـ
+
+397
+00:35:07,070 --> 00:35:10,250
+whether type 2 is due primarily to a defect in
+
+398
+00:35:10,250 --> 00:35:15,290
+beta cell secretion or to peripheral resistance to
+
+399
+00:35:15,290 --> 00:35:21,870
+insulin or to both دايماً كان فيه خلاف إنه إيش
+
+400
+00:35:21,870 --> 00:35:25,850
+الأول؟هل الـ Insulin Resistance هي المشكلة الأولى
+
+401
+00:35:25,850 --> 00:35:29,790
+و اللي بينتج عنها Beta Cell Dysfunction ولا
+
+402
+00:35:29,790 --> 00:35:34,690
+المشكلة الأساسية هي الـ Beta Cell Dysfunction
+
+403
+00:35:34,690 --> 00:35:39,450
+وبالتالي الـ Secretion للإنسلين؟
+
+404
+00:35:42,920 --> 00:35:46,800
+البيانات متوفرة لتدعم المصطلح أن مقاومة الإنسانية
+
+405
+00:35:46,800 --> 00:35:52,040
+مخطط أساسي من خلال المعلومات اللي بقتت متوفرة من
+
+406
+00:35:52,040 --> 00:35:59,080
+خلال طبعا الـ research اللي تم بشكل كبير عندنا ال
+
+407
+00:35:59,080 --> 00:36:04,800
+data بتدعم أن المشكلة الأساسية هي الـ insulin
+
+408
+00:36:04,800 --> 00:36:06,840
+resistance
+
+409
+00:36:09,250 --> 00:36:13,930
+والبعد هيك ممكن يصير في عنا مشكلة بالانسولين
+
+410
+00:36:14,380 --> 00:36:17,440
+secretion، يعني المشكلة الأساسية Insulin
+
+411
+00:36:17,440 --> 00:36:23,420
+resistance واللي ممكن تكون موجودة يعني من فترة
+
+412
+00:36:23,420 --> 00:36:29,340
+طويلة عند المريض واللي بتكون طبعا فيه تزايد لغاية
+
+413
+00:36:29,340 --> 00:36:37,000
+ما فعليا يصير فيه diagnosis للمريض بـ Type 2
+
+414
+00:36:37,000 --> 00:36:40,280
+diabetesمالليتس يبقى ال insulin resistance ممكن
+
+415
+00:36:40,280 --> 00:36:47,560
+تكون موجودة يعني و اتزيد عند المرضى من اللي هو
+
+416
+00:36:47,560 --> 00:36:53,660
+النوع التاني لالـ diabetes طيب ايش سبب ال insulin
+
+417
+00:36:53,660 --> 00:36:56,360
+resistance لان احنا اتفقنا ان المشكلة الأساسية ال
+
+418
+00:36:56,360 --> 00:37:02,230
+insulin resistance الآن في أن genetic factorsتمام
+
+419
+00:37:02,230 --> 00:37:08,510
+يبقى هذه predispose the persons to type 2 diabetes
+
+420
+00:37:08,510 --> 00:37:14,050
+mellitus والآن بيظل أن الشخص هذا يتعرض لل
+
+421
+00:37:14,050 --> 00:37:16,930
+environmental factors يبقى إذا كان ال genetic
+
+422
+00:37:16,930 --> 00:37:21,550
+factors موجودة ال environmental factors الآن
+
+423
+00:37:24,260 --> 00:37:28,800
+تؤدي إلى إصابة أو تعرض الشخص للـ Environmental
+
+424
+00:37:28,800 --> 00:37:34,420
+Factors اللي هنذكرها هتخلي الشخص يصاب بالـ Type 2
+
+425
+00:37:34,420 --> 00:37:39,380
+Diabetes Mellitus يبقى
+
+426
+00:37:39,380 --> 00:37:43,440
+زي ما اتفقنا أن المشكلة الأساسية هي الـ Insulin
+
+427
+00:37:43,440 --> 00:37:44,740
+Resistance
+
+428
+00:37:46,580 --> 00:37:50,100
+والـ الادب بيحاول اللي هو البنك الرياضي انه يصير
+
+429
+00:37:50,100 --> 00:37:56,420
+فيه انها compensation ويصير فيه الوزيادة بيه ال ..
+
+430
+00:37:56,420 --> 00:38:01,980
+يعني الطلب على ال beta cells عشان يتعود ال ..
+
+431
+00:38:01,980 --> 00:38:08,600
+المشكلة اللي صارت بالإنسلين يبقى هذا بيؤدي إلى
+
+432
+00:38:08,600 --> 00:38:13,840
+progressive loss of beta cell functionالتي محتاجة
+
+433
+00:38:13,840 --> 00:38:19,680
+للتطور من الهيبرغلسيميا الانسولينية المقاومة مع
+
+434
+00:38:19,680 --> 00:38:25,140
+اختلاف بيطاسيل مستمر هذا بيؤدي إلى حدوث ارتفاع في
+
+435
+00:38:25,140 --> 00:38:31,460
+الجلوكوز الاختلاف الرئيسي هو اختلاف جلوكوز اندوست
+
+436
+00:38:31,460 --> 00:38:37,440
+انسولينية التي تسمى كالترتيب الجلوكوز غير مجتمع
+
+437
+00:38:37,440 --> 00:38:44,780
+يبقى لما الشخص بيكون طبيعيلمّا بيرتفع لنا الـ
+
+438
+00:38:44,780 --> 00:38:51,020
+glucose هذا بيعمل اللي هو simulation لل beta cells
+
+439
+00:38:51,020 --> 00:38:57,490
+وبيزيد لنا إفراز ال insulinلكن المشكلة هان في
+
+440
+00:38:57,490 --> 00:38:59,870
+الناس اللي عندهم اللي وضعتها بتوع ضيبة Smellitus
+
+441
+00:38:59,870 --> 00:39:05,510
+إنه بيبطل الـ Glucose يعمل اللي هو induction
+
+442
+00:39:05,510 --> 00:39:12,390
+بالشكل الصحيح للإنسلين الريليز وبالتالي بيصير إنه
+
+443
+00:39:12,390 --> 00:39:16,530
+ما يعرف بـ Selective Glucose Unresponsiveness
+
+444
+00:39:18,310 --> 00:39:22,630
+يبقى سبب هذه المشكلة هو الارتفاع المستمر في
+
+445
+00:39:22,630 --> 00:39:28,290
+الجلوكوز يبقى عندنا hyperiglycemia appeared to
+
+446
+00:39:28,290 --> 00:39:32,690
+render the beta cells increasingly unresponsive to
+
+447
+00:39:32,690 --> 00:39:38,350
+glucose يبقى الارتفاع المستمر فيهالجلوكوز تمام
+
+448
+00:39:38,350 --> 00:39:43,710
+بيزيد من اللي هو عدم استجابة خلايا الـ Beta cells
+
+449
+00:39:43,710 --> 00:39:49,830
+للارتفاع وهذا ما يسمى بالـGlucotoxicity
+
+450
+00:39:49,830 --> 00:39:53,530
+The degree of dysfunction correlates with both
+
+451
+00:39:53,530 --> 00:39:57,500
+glucose concentrationand a duration of
+
+452
+00:39:57,500 --> 00:40:02,520
+hyperoglycemia هو كل ما زاد ارتفاع ال glucose كل
+
+453
+00:40:02,520 --> 00:40:09,500
+ما طولت مدة ال hyperoglycemia طبعا كل ما زادت
+
+454
+00:40:09,500 --> 00:40:18,040
+عندنا ال glucotoxicity وبالتالي اللي هو ال ال
+
+455
+00:40:18,040 --> 00:40:23,970
+progressive loss of beta cell functionمن ناحية
+
+456
+00:40:23,970 --> 00:40:28,630
+تانية، عندنا أيضًا الزيادة بالـ Free fatty acids
+
+457
+00:40:28,630 --> 00:40:34,510
+يبقى برضه هذه بتلعب دور في الـ Beta cell failure
+
+458
+00:40:34,510 --> 00:40:41,130
+وهذا ما يُعرف بالـ Lipotoxicity عندنا أيضًا
+
+459
+00:40:41,130 --> 00:40:46,430
+المشكلة اللي ذكرناها سابقًا اللي هو الـ disruption
+
+460
+00:40:46,430 --> 00:40:51,580
+of the normal pulsatile releaseوانسلين هذا ذكرنا
+
+461
+00:40:51,580 --> 00:40:54,380
+سابقا ان الناس اللي عندهم type 2 diabetes mellitus
+
+462
+00:40:54,380 --> 00:40:59,020
+اللي هو بيفقدوا ال normal pulsatile release of
+
+463
+00:40:59,020 --> 00:41:05,880
+انسلين and an increase ratio of plasma pro insulin
+
+464
+00:41:05,880 --> 00:41:12,340
+to insulinأيضًا الـ Insulin Resistance برضه زي ما
+
+465
+00:41:12,340 --> 00:41:20,140
+قلنا بيصير يعني جهد كبير على الـ Beta Cells وهذا
+
+466
+00:41:20,140 --> 00:41:28,600
+برضه بيؤدي إلى النقص في الـ Beta Cells عند الأشخاص
+
+467
+00:41:28,600 --> 00:41:35,120
+المصابين بالـ Type 2 Diabetes Mellitus النقطة
+
+468
+00:41:35,120 --> 00:41:39,010
+التانية الـ Insulin Resistancedefined as decreased
+
+469
+00:41:39,010 --> 00:41:44,050
+biological response to normal concentrations of
+
+470
+00:41:44,050 --> 00:41:48,350
+circulating insulin بيبطل فيه أنه اللي هي
+
+471
+00:41:48,350 --> 00:41:50,890
+الاستجابة الطبيعية
+
+472
+00:41:55,010 --> 00:42:00,370
+من قبل الخلايا لـ ال .. اللي هي الـ concentration
+
+473
+00:42:00,370 --> 00:42:03,650
+الطبيعية من الـ insulin يبقى الـ concentration
+
+474
+00:42:03,650 --> 00:42:09,310
+الطبيعية من الـ insulin بتبطل كافية للتعامل مع الـ
+
+475
+00:42:09,310 --> 00:42:12,970
+glucose اللي موجود بالدم طبعا الـ insulin
+
+476
+00:42:12,970 --> 00:42:17,750
+resistance موجودة في اللي هو حالات مختلفة يعني إن
+
+477
+00:42:17,750 --> 00:42:26,180
+في ال obese persons non-diabetic individualsand in
+
+478
+00:42:26,180 --> 00:42:32,900
+patients with type 2 diabetes mellitus طيب
+
+479
+00:42:32,900 --> 00:42:37,780
+الآن المشكلة و ال pathophysiologic defect يعني مش
+
+480
+00:42:37,780 --> 00:42:45,460
+.. ما تمش .. ما تمش تعرف عليه بشكل كامل لكن ال
+
+481
+00:42:45,460 --> 00:42:47,860
+insulin resistance مشكلة ال insulin resistance
+
+482
+00:42:47,860 --> 00:42:52,380
+usually attributed to a defect in insulin action
+
+483
+00:42:52,380 --> 00:42:57,750
+يبقى في عملالانسولين، measurement of insulin
+
+484
+00:42:57,750 --> 00:43:01,110
+resistance in a routine clinical setting is
+
+485
+00:43:01,110 --> 00:43:05,290
+difficultوأختيارات الـ Surrogate، بمعنى الـ
+
+486
+00:43:05,290 --> 00:43:08,950
+Concentration of Fasting Insulin أو الـ U-Glycemic
+
+487
+00:43:08,950 --> 00:43:14,910
+Insulin Clamp تستخدم لإعادة تجارب انسلين غير
+
+488
+00:43:14,910 --> 00:43:18,310
+مباشرة يبقى موضوع انه انقيز الانسلين resistance
+
+489
+00:43:18,310 --> 00:43:23,710
+يعني موضوع صعب اللي هو ننقيزه بطريقة مباشرة لكن
+
+490
+00:43:23,710 --> 00:43:27,950
+ممكن انقيز الانسلين resistance بطريقة غير مباشرة
+
+491
+00:43:27,950 --> 00:43:32,770
+زي ما ذكرنا سابقاممكن من خلال ال fasting اللي هو
+
+492
+00:43:32,770 --> 00:43:36,010
+انسولين مع ال fasting الجلوكوز ممكن نحسب اللي هو
+
+493
+00:43:36,010 --> 00:43:41,550
+IR تماما اللي بتعبر عن ال insulin resistance
+
+494
+00:43:43,840 --> 00:43:48,740
+اللي هم IR ليه اختصار لـ Homostatic Model
+
+495
+00:43:48,740 --> 00:43:54,560
+Assessment of Insulin Resistance من خلاله ممكن
+
+496
+00:43:54,560 --> 00:43:57,700
+نشوف
+
+497
+00:43:57,700 --> 00:44:01,540
+إذا كان الشخص عنده Insulin Resistance أو لا، هنا
+
+498
+00:44:01,540 --> 00:44:08,150
+أيضًا طريقة أخرى الـ Euglycemic Insulin Clampوها
+
+499
+00:44:08,150 --> 00:44:13,650
+دي يعني more invasive وبتحتاج اللي هو وقت أطول
+
+500
+00:44:13,650 --> 00:44:17,210
+ليعني عملها
+
+501
+00:44:20,560 --> 00:44:23,320
+الـ Euglycemic clamp performed in the hospital
+
+502
+00:44:23,320 --> 00:44:28,720
+under closed supervision و لازم بيه المستشفى و
+
+503
+00:44:28,720 --> 00:44:37,120
+الشخص طبعا intravenously بيعطى infusion of insulin
+
+504
+00:44:37,120 --> 00:44:40,680
+constant intravenous infusion of insulin بيعطى
+
+505
+00:44:40,680 --> 00:44:50,090
+اللي هو كمية ثابتة من الانسلينمع إعطاءه لكميات أو
+
+506
+00:44:50,090 --> 00:44:54,590
+variable amounts of glucose يبقى بإيد بيصير فيه
+
+507
+00:44:54,590 --> 00:44:59,010
+إنه constant infusion لإنسلين وبالإيد التاني بنبدأ
+
+508
+00:44:59,010 --> 00:45:07,730
+نعطيه اللي هو كميات اللي هو من ال glucose to
+
+509
+00:45:07,730 --> 00:45:10,250
+maintain blood glucose at a normal fasting
+
+510
+00:45:10,250 --> 00:45:13,940
+concentrationلأن زي ما احنا عارفين ما زال يعطينا
+
+511
+00:45:13,940 --> 00:45:17,220
+انسلين بجه يبدأ الـ glucose بالتناقص بجه بنبدأ
+
+512
+00:45:17,220 --> 00:45:22,220
+نعطيه glucose اللي هو برضه intravenously و لازم
+
+513
+00:45:22,220 --> 00:45:25,760
+يعني بتتم بالمستشفى لأنه يعني موضوع أنه نعطي لا
+
+514
+00:45:25,760 --> 00:45:31,460
+المريض insulin طبعا يعني مش سهل و ممكن الشخص إذا
+
+515
+00:45:31,460 --> 00:45:35,320
+مافيش عندنا متابعة مستمرة للجلوس في الدم ممكن
+
+516
+00:45:35,320 --> 00:45:42,240
+الشخص يدخل بـ hypoglycemia يبقى insulinومن ناحية
+
+517
+00:45:42,240 --> 00:45:47,680
+تانية بنعطيه Glucose وفيه متابعة مستمرة لـ Glucose
+
+518
+00:45:47,680 --> 00:45:50,420
+Concentration على أساس إنه الـ Glucose
+
+519
+00:45:50,420 --> 00:45:54,900
+Concentration تكون نفس الـ Concentration اللي هو
+
+520
+00:45:54,900 --> 00:45:59,700
+في إذا كان الشخص صايم، يعني من 70 ل110
+
+521
+00:46:02,350 --> 00:46:04,370
+عبر مجال الوضع اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ
+
+522
+00:46:04,370 --> 00:46:06,890
+اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ
+
+523
+00:46:06,890 --> 00:46:11,430
+اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ
+
+524
+00:46:11,430 --> 00:46:11,430
+اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ
+
+525
+00:46:11,430 --> 00:46:11,470
+اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ
+
+526
+00:46:11,470 --> 00:46:12,930
+اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ
+
+527
+00:46:12,930 --> 00:46:14,670
+اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ
+
+528
+00:46:14,670 --> 00:46:15,210
+اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ
+
+529
+00:46:15,210 --> 00:46:16,710
+اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ
+
+530
+00:46:16,710 --> 00:46:19,530
+اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ اللاجئ
+
+531
+00:46:19,530 --> 00:46:24,830
+اللاجئ اللاجئ اللاجئ
+
+532
+00:46:24,830 --> 00:46:29,280
+اللاجهنلاقي إنه ال .. هدول الناس هيكون في عندهم
+
+533
+00:46:29,280 --> 00:46:35,880
+زيادة في ال endogenous insulinتمام؟ و الحالة
+
+534
+00:46:35,880 --> 00:46:41,900
+التانية أنه يكون في عنا اللي هو hyperglycemia يبقى
+
+535
+00:46:41,900 --> 00:46:47,900
+حالاجي انه ال .. ال glucose concentration يعني
+
+536
+00:46:47,900 --> 00:46:51,900
+مرتفع و أكتر من اللي هو ال normal fasting
+
+537
+00:46:51,900 --> 00:46:56,960
+concentration طبعاً مع ال large doses of exogenous
+
+538
+00:46:56,960 --> 00:47:01,080
+insulin اللي زي ما قلنا بتمحقنها at a constant
+
+539
+00:47:01,080 --> 00:47:02,680
+concentration
+
+540
+00:47:05,210 --> 00:47:08,990
+يبقى المريض، زي ما قلنا بنعطيه الـ Constant
+
+541
+00:47:08,990 --> 00:47:14,950
+Insulin Infusion وعناها Variable Glucose Infusion
+
+542
+00:47:14,950 --> 00:47:19,570
+وفي عنا اللي هو Frequent Blood Sampling عشان انقاذ
+
+543
+00:47:19,570 --> 00:47:27,170
+مستوى الـ Glucose وعنا زي ما قلنا Variable Glucose
+
+544
+00:47:27,170 --> 00:47:30,350
+Infusion يعني دايما فيه بناء على الـ Concentration
+
+545
+00:47:31,420 --> 00:47:36,580
+adjust a glucose infusion to اللي هو clam blood
+
+546
+00:47:36,580 --> 00:47:38,220
+glucose levels
+
+547
+00:47:40,900 --> 00:47:45,200
+يبقى من خلال الـ… الـEuglycemic اللي هو Glucose
+
+548
+00:47:45,200 --> 00:47:49,400
+إقلام يبقى بنشوف بطريقة مباشرة measure of the
+
+549
+00:47:49,400 --> 00:47:53,400
+whole body glucose disposal بنشوف قداش الجسم قادر
+
+550
+00:47:53,400 --> 00:47:57,960
+على التخلص من الجلوكوز اللي قاعدين نعمله infusion
+
+551
+00:47:57,960 --> 00:48:02,060
+at a given level of insulinemia زي ما قولنا عندنا
+
+552
+00:48:02,060 --> 00:48:08,990
+اللي هو constant infusion ofinsulin under steady
+
+553
+00:48:08,990 --> 00:48:17,510
+state conditions وزي ما شوفنا أنه يعني ممكن إذا
+
+554
+00:48:17,510 --> 00:48:20,910
+كان عندنا ال glucose concentration اللي هو طبيعي
+
+555
+00:48:20,910 --> 00:48:27,370
+مع زيادة في ال insulin concentration أو مع ال
+
+556
+00:48:27,370 --> 00:48:31,410
+oxygenous insulin زي ما قلنا ممكن الجسم يكون برضه
+
+557
+00:48:31,410 --> 00:48:35,480
+غير قادرعلى التعامل مع كميات الـ Glucose اللي
+
+558
+00:48:35,480 --> 00:48:41,740
+بتدخل لجسم لأنه الـ Insulin Resistance عالية ذكرنا
+
+559
+00:48:41,740 --> 00:48:44,660
+إنه في حالات أخرى برضه بيصير فيها إنها اللي هو
+
+560
+00:48:44,660 --> 00:48:47,200
+Insulin Resistance ومنها دي الحالات اللي هو
+
+561
+00:48:47,200 --> 00:48:51,740
+Syndrome X أو ما يُعرف بالـ Metabolic Syndrome
+
+562
+00:48:51,740 --> 00:48:55,060
+Group of Associated Clinical and Laboratory
+
+563
+00:48:55,060 --> 00:48:59,120
+Finding وهدول أشخاص بيكون في عندهم Insulin
+
+564
+00:48:59,120 --> 00:49:03,080
+Resistanceبيكون فيه hyperinsulinemia ارتفاع في
+
+565
+00:49:03,080 --> 00:49:06,120
+اللي هو الـ insulin concentration، obesity، و
+
+566
+00:49:06,120 --> 00:49:10,060
+dyslipidemia اللي هو بتشمل ارتفاع في الـ
+
+567
+00:49:10,060 --> 00:49:18,620
+triglycerides، اللي هو الانخفاض
+
+568
+00:49:18,620 --> 00:49:24,120
+في الـ high density lipoprotein، وموجود أيضًا
+
+569
+00:49:24,120 --> 00:49:27,910
+hypertensionالشخصين الذين يمتلوا هذا الاندروام
+
+570
+00:49:27,910 --> 00:49:34,510
+يكونوا في أكتر فرصة لمرحلة الكاردوفاسكالية طبعا
+
+571
+00:49:34,510 --> 00:49:38,980
+بالنسبة لل type 2 diabetes mellitusالـ Genetics
+
+572
+00:49:38,980 --> 00:49:44,740
+بتلعب دور أكبر يبقى وجود الـ Genetic Factors بتخلي
+
+573
+00:49:44,740 --> 00:49:50,140
+الشخص يعني طبعاً at higher risk لإصابة بالـ Type 2
+
+574
+00:49:50,140 --> 00:49:53,060
+Diabetes Mellitus طبعاً مع وجود الـ Environmental
+
+575
+00:49:53,060 --> 00:49:59,040
+Factors يعني لاحقاً Environmental Factors such as
+
+576
+00:49:59,040 --> 00:50:02,380
+diet and exercise are important determinants in
+
+577
+00:50:02,380 --> 00:50:05,860
+the pathogenesis of Type 2 Diabetes Mellitus يبقى
+
+578
+00:50:05,860 --> 00:50:11,020
+الـ diet و الـ exerciseو إذا كان ال genetic
+
+579
+00:50:11,020 --> 00:50:18,640
+factors موجودة و الشخص مش محافظ يعني على غذاء
+
+580
+00:50:18,640 --> 00:50:27,260
+سليم، فيش exercise، حياته فيش فيها حركة، فيه خمول،
+
+581
+00:50:27,260 --> 00:50:32,940
+يبقى معناته هذا الشخص يعني معرض بشكل كبير للإصابة
+
+582
+00:50:32,940 --> 00:50:38,900
+بال type 2 diabetes malatusالوثيقة الوثيقة الوثيقة
+
+583
+00:50:38,900 --> 00:50:40,880
+الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة
+
+584
+00:50:40,880 --> 00:50:45,700
+الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة
+
+585
+00:50:45,700 --> 00:50:53,540
+الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة
+
+586
+00:50:53,540 --> 00:50:56,560
+الوثيقة
+
+587
+00:50:57,020 --> 00:51:02,500
+يعني إما obese أو overweight، يبقى فيه عندنا علاقة
+
+588
+00:51:02,500 --> 00:51:06,900
+بين الـ obesity وبين الـ type 2 diabetes mellitus
+
+589
+00:51:10,840 --> 00:51:17,580
+طيب هل كل الأشخاص ال .. ال .. ال obese يعني ممكن
+
+590
+00:51:17,580 --> 00:51:21,800
+يصابوا أو لازم يصابوا بـ type 2 diabetes malatus
+
+591
+00:51:21,800 --> 00:51:28,220
+لأ يعني عندنا ال .. ال .. الأشخاص اللي هو ال .. ال
+
+592
+00:51:28,220 --> 00:51:31,820
+obese less than 15 percent of obese individuals
+
+593
+00:51:31,820 --> 00:51:39,180
+will develop diabetes تمام؟جهد مرتبط بممكن الـ
+
+594
+00:51:39,180 --> 00:51:41,220
+Genetic Factors، يعني ممكن الـ Genetic Factors ما
+
+595
+00:51:41,220 --> 00:51:44,700
+تكونش موجودة، لكن يكون الشخص اللي هو obese ومافيش
+
+596
+00:51:44,700 --> 00:51:48,580
+exercise والأمور الأخرى، لكن إذا كان الـ Genetic
+
+597
+00:51:48,580 --> 00:51:55,180
+Factors موجودة والشخص كان obese ومافيش exercise
+
+598
+00:51:55,180 --> 00:51:58,660
+والـ Risk Factors الأخرى، يبقى ممكن يصاب بالـ Type
+
+599
+00:51:58,660 --> 00:52:02,820
+2 Diabetes Malicious، بقى مش شرط أنه عشان obese
+
+600
+00:52:02,820 --> 00:52:07,980
+يصاب، لكن زي ما قلنا أنه فيإذا الـ genetic factors
+
+601
+00:52:07,980 --> 00:52:12,520
+موجودة و الشخص كان obese يبقى معناته الفرصة أكبر
+
+602
+00:52:12,520 --> 00:52:16,560
+أن يصاب بي الـ type 2 diabetes mellitus إن 60% to
+
+603
+00:52:16,560 --> 00:52:20,320
+80% of patients with type 2 diabetes mellitus are
+
+604
+00:52:20,320 --> 00:52:21,200
+obese
+
+605
+00:52:26,260 --> 00:52:29,900
+يبقى ممكن الشخص يكون obese لكن ما عندهوش اللي هو
+
+606
+00:52:29,900 --> 00:52:34,340
+type 2 diabetes mellitus لكن هلاجي أنه في عنده
+
+607
+00:52:34,340 --> 00:52:39,220
+مشكلة بيه اللي هو ال carbohydrate tolerance في
+
+608
+00:52:39,220 --> 00:52:43,060
+التعامل مع ال carbohydrates ويدو الأشخاص هلاجي أنه
+
+609
+00:52:43,060 --> 00:52:47,100
+في عندهم hyperinsulinemia and are insulin
+
+610
+00:52:47,100 --> 00:52:48,220
+resistant
+
+611
+00:52:50,730 --> 00:52:54,910
+يبقى عندنا اللي هو الـ Obesity عامل في الـ Genetic
+
+612
+00:52:54,910 --> 00:52:57,250
+Predisposition و اللي هو الـ Family History طبعاً
+
+613
+00:52:57,250 --> 00:52:59,810
+يفتح بتوعي ده باسم الـ Lettuce و ان الـ Duration
+
+614
+00:52:59,810 --> 00:53:04,850
+of Obesity و الـ Distribution of Fat يبقى كمان
+
+615
+00:53:04,850 --> 00:53:09,290
+اللي هو مناطق توزيع الـ Fat و طبعاً إذا كان اللي
+
+616
+00:53:09,290 --> 00:53:14,570
+هو الـ Fat موزع في اللي هو الـ Trunk أو في موزع في
+
+617
+00:53:14,570 --> 00:53:19,920
+اللي هو منطقة ال .. الوسط تمام يبقىهدول الوقت هي
+
+618
+00:53:19,920 --> 00:53:26,300
+الـ risk للإصابة بـ Type 2 Diabetes Mellitus It is
+
+619
+00:53:26,300 --> 00:53:28,840
+important to note that intervention can delay or
+
+620
+00:53:28,840 --> 00:53:32,920
+prevent the onset of Type 2 Diabetes Mellitus طبعا
+
+621
+00:53:32,920 --> 00:53:36,240
+إذا كان الشخص ما يصاب بـ Type 2 Diabetes Mellitus
+
+622
+00:53:36,240 --> 00:53:43,930
+فهنا مرحلة الـ pre-diabetes الآن في هذه المرحلةإذا
+
+623
+00:53:43,930 --> 00:53:52,250
+كان صار فيه تدخل وصار فيه تنظيم للأكل صار فيه
+
+624
+00:53:52,250 --> 00:53:57,290
+exercise صار فيه حركة عند هذا الشخص بيبقى ممكن
+
+625
+00:53:57,290 --> 00:54:02,330
+فعليًا يعني نأخر أو نمنع من حدوث الـ Type 2
+
+626
+00:54:02,330 --> 00:54:08,730
+Diabetes Mellitus وهذا تم طبعًا إثباته من خلال
+
+627
+00:54:08,730 --> 00:54:10,170
+اللي هو دراسات
+
+628
+00:54:12,560 --> 00:54:14,120
+تو عملية عملية عملية عملية عملية عملية عملية عملية
+
+629
+00:54:14,120 --> 00:54:14,700
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+630
+00:54:14,700 --> 00:54:18,340
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+631
+00:54:18,340 --> 00:54:20,260
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+632
+00:54:20,260 --> 00:54:24,260
+عملية عملية عملية عملية عملية عملية
+
+633
+00:54:24,260 --> 00:54:24,320
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+634
+00:54:24,320 --> 00:54:24,860
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+635
+00:54:24,860 --> 00:54:24,860
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+636
+00:54:24,860 --> 00:54:26,940
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+637
+00:54:26,940 --> 00:54:32,430
+عملية عملية عملية عمليةوهي مش شرط أن يكون الخسارة
+
+638
+00:54:32,430 --> 00:54:37,270
+لوزن بشكل كبير عشان نقلل من ال risk يعني ال weight
+
+639
+00:54:37,270 --> 00:54:41,210
+loss was modest صار فيه نقص بالوزن الو خمسة إلى
+
+640
+00:54:41,210 --> 00:54:46,190
+سبعة بالمية لكن the rate of progression to type 2
+
+641
+00:54:46,190 --> 00:54:48,770
+diabetes pellitus was reduced by fifty eight
+
+642
+00:54:48,770 --> 00:54:54,910
+percentin both studies، حتى مع خسارة بالوزن بنسبة
+
+643
+00:54:54,910 --> 00:55:00,830
+قليلة، إلا إن هذه الخسارة بتقلل من احتمالية
+
+644
+00:55:00,830 --> 00:55:05,070
+الإصابة بالـ Type 2 diabetes mellitus بنسبة كبيرة،
+
+645
+00:55:05,070 --> 00:55:11,250
+اللي هو زي ما واضح من هدول الدراسين، 58%. This
+
+646
+00:55:11,250 --> 00:55:14,410
+observation has been validated by several other
+
+647
+00:55:14,410 --> 00:55:18,650
+studies، كمان دراسات أخرى أكدت هذا الموضوع.
+
+648
+00:55:21,300 --> 00:55:26,640
+وفي عندنا اللي هو علاقة عكسية بين الـ degree of
+
+649
+00:55:26,640 --> 00:55:30,680
+physical activity and the prevalence of type 2
+
+650
+00:55:30,680 --> 00:55:38,020
+diabetes mellitus النقطة الأخرى اللي هو عندنا الـ
+
+651
+00:55:38,020 --> 00:55:41,800
+geneticsوزي ما قلنا إن الـ Genetics في الـ type 2
+
+652
+00:55:41,800 --> 00:55:45,500
+diabetes mellitus يعني بتلعب دور أكبر، it is
+
+653
+00:55:45,500 --> 00:55:47,820
+widely acknowledged that genetic factors
+
+654
+00:55:47,820 --> 00:55:51,240
+contribute to the development of type 2 diabetes
+
+655
+00:55:51,240 --> 00:55:56,720
+mellitus ولمّا نحكي على ال concordance rate for
+
+656
+00:55:56,720 --> 00:55:59,720
+type 2 diabetes mellitus in identical twins
+
+657
+00:55:59,720 --> 00:56:03,360
+approaches 100%
+
+658
+00:56:05,950 --> 00:56:09,390
+ويقولنا إن الـ genetic factors مهمة وبالتالي type
+
+659
+00:56:09,390 --> 00:56:12,170
+2 diabetes mellitus is ten times more likely to
+
+660
+00:56:12,170 --> 00:56:16,210
+occur in an obese person with a diabetic parent
+
+661
+00:56:16,210 --> 00:56:21,510
+بما أنته فيه هنا إن ال genetic factors موجودة وإن
+
+662
+00:56:21,510 --> 00:56:24,030
+احتماليتي بإصابة هذا الشخص بيقل type 2 diabetes
+
+663
+00:56:24,030 --> 00:56:30,870
+mellitus زي ما يقولون طبعا بـ equally obese person
+
+664
+00:56:30,870 --> 00:56:33,530
+without a diabetic family history
+
+665
+00:56:35,960 --> 00:56:39,740
+However, the mood of inheritance is unknown
+
+666
+00:56:43,890 --> 00:56:49,530
+طب ما في عندنا أمراض عديدة بتكون المشكلة موجودة في
+
+667
+00:56:49,530 --> 00:56:55,030
+اللي هو single locus زي cystic fibrosis زي Deutsch
+
+668
+00:56:55,030 --> 00:57:00,470
+-Niemuscular Dystrophy لكن بما يتعلق بالـDiabetes
+
+669
+00:57:00,470 --> 00:57:08,750
+Mellitus هان عندنا المشكلة بتتعلق بـMultiple
+
+670
+00:57:08,750 --> 00:57:13,570
+Genetic Factorsوهذه الوضعيات أكتر مجنونة جنوناتيا
+
+671
+00:57:13,570 --> 00:57:18,390
+ومجموعة من الوضعيات الجنوانية تتعامل مع انفلوانات
+
+672
+00:57:18,390 --> 00:57:19,710
+إكسوجينية
+
+673
+00:57:27,310 --> 00:57:32,830
+factors وطبعا من هذه الأمراض اللي عندنا multi
+
+674
+00:57:32,830 --> 00:57:35,550
+genetic factors ممكن اللي هو تكون بتلعب دور زي الـ
+
+675
+00:57:35,550 --> 00:57:38,150
+diabetes mellitus زي الـ atherosclerosis،
+
+676
+00:57:38,150 --> 00:57:41,590
+hypertension، osteoporosis
+
+677
+00:57:44,400 --> 00:57:49,540
+طبعًا باستخدام اللي هو طرق مختلفة تم الكشف عن يعني
+
+678
+00:57:49,540 --> 00:57:56,220
+عدد من الجينات اللي لها علاقة بالاصابة بـ Type 2
+
+679
+00:57:56,220 --> 00:58:02,300
+Diabetes Mellitus وعنا من الدراسات اللي تم
+
+680
+00:58:02,300 --> 00:58:04,900
+استخدامها اللي هو الـ Genome-wide Association
+
+681
+00:58:04,900 --> 00:58:13,900
+Studies وهذا النوع من الدراسات يعني طبعًا إشارةأو
+
+682
+00:58:13,900 --> 00:58:21,260
+كان له دور كبير في ربط العديد من الـ genes بمرض
+
+683
+00:58:21,260 --> 00:58:24,580
+اللي هو الـ type 2 diabetes malatus with more than
+
+684
+00:58:24,580 --> 00:58:29,180
+60 genetic low key now identified
+
diff --git a/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/_h2KNL9Vj6A.srt b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/_h2KNL9Vj6A.srt
new file mode 100644
index 0000000000000000000000000000000000000000..ff5e342ba8e4b5bc76f4a93ee9fd0f9343d3d77b
--- /dev/null
+++ b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/_h2KNL9Vj6A.srt
@@ -0,0 +1,1450 @@
+1
+00:00:02,870 --> 00:00:07,210
+Categories of increased risk for diabetes. بيقنّا
+
+2
+00:00:07,210 --> 00:00:12,410
+الفئات اللي احتمالية الإصابة بـ diabetes
+
+3
+00:00:12,410 --> 00:00:18,710
+عندهم أعلى. أول شيء بيقنّا impaired glucose
+
+4
+00:00:18,710 --> 00:00:22,330
+tolerance. People who have blood glucose
+
+5
+00:00:22,330 --> 00:00:26,490
+concentrations above normal, but less than those
+
+6
+00:00:26,490 --> 00:00:33,290
+required for diagnosis of diabetes mellitus. وهذا
+
+7
+00:00:33,290 --> 00:00:43,410
+اللي هو مرتبط بقياس للجلوكوز عن طريق الـ
+
+8
+00:00:43,410 --> 00:00:48,890
+Oral Glucose Tolerance Test. وعندنا
+
+9
+00:00:48,890 --> 00:00:55,650
+القياس لجلوكوز بعد ساعتين من إعطاء الجرعة
+
+10
+00:00:55,650 --> 00:01:01,580
+لجلوكوز بيكون بين مئة وأربعين إلى مئة وتسعة
+
+11
+00:01:01,580 --> 00:01:06,260
+و التسعين. طبعاً، في هذه الحالة، يعني ما نقدرش نقول أن هذا
+
+12
+00:01:06,260 --> 00:01:11,420
+عنده diabetes mellitus، لأن عشان نقول أنه عنده
+
+13
+00:01:11,420 --> 00:01:14,480
+diabetes mellitus، المفروض يكون الـ glucose
+
+14
+00:01:14,480 --> 00:01:22,260
+concentration أكثر من 200، و الـ normal أقل من 140.
+
+15
+00:01:22,260 --> 00:01:28,990
+لأ، هو ما هو مع الـ normal، ولا هو مع الأشخاص اللي مصابين
+
+16
+00:01:28,990 --> 00:01:34,650
+بالسكري. في 140 لـ 199، هذا الشخص بيكون عنده ما يسمى
+
+17
+00:01:34,650 --> 00:01:41,270
+بـ Impaired Glucose Tolerance، أو اللي بنسميهم، أو
+
+18
+00:01:41,270 --> 00:01:46,010
+بنسمي هذه المرحلة يعني pre-diabetes، اللي هي مرحلة
+
+19
+00:01:46,010 --> 00:01:48,490
+ما قبل السكري.
+
+20
+00:01:53,340 --> 00:01:55,620
+لتخلص من جلوكوز. صحيح. صحيح. الصحيح. الصحيح. الصحيح.
+
+21
+00:01:55,620 --> 00:01:56,320
+الصحيح. الصحيح. الصحيح. الصحيح. الصحيح. الصحيح. الصحيح.
+
+22
+00:01:56,320 --> 00:02:02,000
+الصحيح. الصحيح. الصحيح. الصحيح. الصحيح. الصحيح. الصحيح.
+
+23
+00:02:02,000 --> 00:02:02,780
+الصحيح. الصحيح. الصحيح. الصحيح. الصحيح. الصحيح. الصحيح.
+
+24
+00:02:02,780 --> 00:02:07,560
+الصحيح. الصحيح. الصحيح. الصحيح. الصحيح. الصحيح. الصحيح.
+
+25
+00:02:07,560 --> 00:02:08,040
+الصحيح. الصحيح. الصحيح. الصحيح. الصحيح. الصحيح. الصحيح.
+
+26
+00:02:08,040 --> 00:02:08,300
+الصحيح. الصحيح. الصحيح. الصحيح. الصحيح. الصحيح. الصحيح.
+
+27
+00:02:08,300 --> 00:02:13,500
+الصحيح. الصحيح. الصحيح. الصحيح. الصحيح. الصحيح. بعد هيك
+
+28
+00:02:13,500 --> 00:02:16,160
+يعني عشان يتجنبوا استخدام الـ oral glucose
+
+29
+00:02:16,160 --> 00:02:21,260
+tolerance test، صار في عندنا اللي هو، اللي هي
+
+30
+00:02:21,260 --> 00:02:24,780
+category أو مصطلح آخر، اللي يسمى impaired fasting
+
+31
+00:02:24,780 --> 00:02:29,540
+glucose. و
+
+32
+00:02:29,540 --> 00:02:35,540
+هذه تم إضافتها طبعاً عن طريق الـ ADA، الـ American
+
+33
+00:02:35,540 --> 00:02:42,270
+Diabetes Association. ولاحقاً برضه تم إضافتها من
+
+34
+00:02:42,270 --> 00:02:49,510
+خلال الـ WHO في العام تسعة وتسعين. الـ
+
+35
+00:02:49,510 --> 00:02:52,310
+impaired fasting glucose diagnosed by fasting
+
+36
+00:02:52,310 --> 00:02:55,590
+glucose value between those of normal and diabetic
+
+37
+00:02:55,590 --> 00:03:01,330
+individuals. وها برضه نفس الـ issue. المفروض الشخص
+
+38
+00:03:01,330 --> 00:03:05,110
+طبيعي، إذا كان الـ glucose عنده، طبعاً احنا بنحكي على
+
+39
+00:03:05,110 --> 00:03:10,910
+glucose لشخص صائم. الـ glucose بده يكون طبيعي، إذا
+
+40
+00:03:10,910 --> 00:03:16,410
+كان أقل من مئة، و بده يكون عنده diabetes إذا كان الـ
+
+41
+00:03:16,410 --> 00:03:21,030
+concentration أكثر من 126. يبقى الـ concentration
+
+42
+00:03:21,030 --> 00:03:27,800
+هان بين مئة و الـ 125 ملي جرام per ديسيلتر. وبالتالي
+
+43
+00:03:27,800 --> 00:03:32,580
+لا هو normal، ولا هو diabetic. برضه هذه المرحلة اللي
+
+44
+00:03:32,580 --> 00:03:36,280
+هو بنسميها pre-diabetes،  بمرحلة الـ pre-diabetes
+
+45
+00:03:36,280 --> 00:03:41,420
+ممكن نشخصها من خلال استخدام الـ Oral Glucose
+
+46
+00:03:41,420 --> 00:03:45,840
+Tolerance Test، وزي ما قلنا، اللي هو بعد ساعتين
+
+47
+00:03:45,840 --> 00:03:52,030
+بده يكون عندنا الـ concentration بين 140 لـ 199، أو من
+
+48
+00:03:52,030 --> 00:03:58,590
+خلال فحص الجلوكوز لشخص صائم، وبتكون الـ
+
+49
+00:03:58,590 --> 00:04:05,910
+concentration بين 100 إلى 125. طبعاً،
+
+50
+00:04:05,910 --> 00:04:08,930
+هذه الـ concentration اللي هو 100 إلى 125
+
+51
+00:04:08,930 --> 00:04:14,770
+بناءً على الـ American Diabetes Association. لكن
+
+52
+00:04:14,770 --> 00:04:22,450
+بالنسبة للـ WHO، الأرقام مختلفة، و الـ WHO بتعتبر أنه
+
+53
+00:04:22,450 --> 00:04:30,710
+الـ cut-off value للـ normal 110، ومش
+
+54
+00:04:30,710 --> 00:04:36,810
+100. وبالتالي، إذا كان عند الشخص الـ concentration للـ
+
+55
+00:04:36,810 --> 00:04:41,270
+glucose الـ fasting، اللي هو الـ glucose من 110 لـ 125،
+
+56
+00:04:42,940 --> 00:04:47,440
+بناءً طبعاً على اللي هو الـ WHO، يبقى بنقول أن هذا
+
+57
+00:04:47,440 --> 00:04:58,420
+الشخص عنده pre-diabetes. في
+
+58
+00:04:58,420 --> 00:05:04,880
+2009 تم إضافة اللي هو فحص آخر، اللي
+
+59
+00:05:04,880 --> 00:05:09,280
+هو برضه detection of pre-diabetes status،
+
+60
+00:05:09,280 --> 00:05:11,660
+اللي هو الـ hemoglobin A1C.
+
+61
+00:05:14,730 --> 00:05:19,910
+الناس مع قيمة hemoglobin A1C تحت 6.5  diabetes إلى
+
+62
+00:05:19,910 --> 00:05:24,890
+ولكن أعلى من القيمة الطبيعية هم في  حرص عالي
+
+63
+00:05:24,890 --> 00:05:32,270
+للتطور إلى diabetes. إذا كان الـ hemoglobin A1C أعلى من
+
+64
+00:05:32,270 --> 00:05:38,070
+6.5، معناته هذا الشخص diabetic.
+
+65
+00:05:39,420 --> 00:05:45,840
+وإذا أقل من 5.7 normal. يبقى إذا كان فحصنا الـ
+
+66
+00:05:45,840 --> 00:05:50,860
+hemoglobin A1C ولاقيناها بين 5.7 و 6.4، يبقى برضه
+
+67
+00:05:50,860 --> 00:05:56,020
+هذا اللي هو الشخص اللي في مرحلة الـ pre-diabetes
+
+68
+00:05:56,020 --> 00:06:03,480
+وعنده الـ risk عالي للإصابة بـ diabetes. يبقى
+
+69
+00:06:03,480 --> 00:06:09,390
+عندنا أكثر من فحص ممكن يتم استخدامهم، وممكن من
+
+70
+00:06:09,390 --> 00:06:16,010
+خلالهم نحدد الناس اللي يعني أكثر عرضة، أو at higher
+
+71
+00:06:16,010 --> 00:06:22,250
+risk للإصابة بـ diabetes. بالنسبالي
+
+72
+00:06:22,250 --> 00:06:28,870
+الهرمونات اللي بتنظم مستوى الـ blood glucose في
+
+73
+00:06:28,870 --> 00:06:34,680
+عندنا نوعين من الهرمونات، في عندنا الـ hypoglycemic
+
+74
+00:06:34,680 --> 00:06:41,360
+hormones، وفينا الـ hyperglycemic hormones. الـ
+
+75
+00:06:41,360 --> 00:06:45,680
+hypoglycemic hormones طبعاً إنها هرمون واحد هو الـ
+
+76
+00:06:45,680 --> 00:06:50,620
+insulin. هذا الهرمون الوحيد اللي بيعمل على تخفيض
+
+77
+00:06:50,620 --> 00:06:55,740
+مستوى الجلوكوز في الدم. بينما الـ hyperglycemic
+
+78
+00:06:55,740 --> 00:07:02,610
+hormones إنها هرمونات عديدة بتعمل على رفع مستوى
+
+79
+00:07:02,610 --> 00:07:08,410
+الجلوكوز في الدم، زي عندنا طبعاً الـ glucagon، الـ
+
+80
+00:07:08,410 --> 00:07:13,990
+epinephrine، عندنا الـ growth hormone، الـ cortisol،
+
+81
+00:07:13,990 --> 00:07:19,550
+كلها هرمونات بتعمل على زيادة مستوى الجلوكوز
+
+82
+00:07:19,550 --> 00:07:21,190
+في الدم.
+
+83
+00:07:30,410 --> 00:07:37,970
+Normal glucose disposal depends on. يبقى عشان الـ
+
+84
+00:07:37,970 --> 00:07:44,890
+glucose اللي بيدخل الدم، عشان نقدر نخفضه، يبقى
+
+85
+00:07:44,890 --> 00:07:51,090
+لا بد أن يكون عندنا الأمور التالية. الأمر الأول، the
+
+86
+00:07:51,090 --> 00:07:55,250
+ability of the pancreas to secrete insulin. يبقى
+
+87
+00:07:55,250 --> 00:07:58,090
+لازم يكون فيه قدرة للـ pancreas طبعاً على إفراز
+
+88
+00:07:58,090 --> 00:08:02,540
+الـ insulin. والنقطة الثانية، ability of insulin to
+
+89
+00:08:02,540 --> 00:08:06,100
+promote uptake of glucose into peripheral tissue.
+
+90
+00:08:06,100 --> 00:08:11,000
+يبقى النقطة الثانية، اللي هو أن الـ insulin action
+
+91
+00:08:11,000 --> 00:08:17,260
+يرتبط الـ insulin مع الخلايا، وفعلياً يعمل على دخول
+
+92
+00:08:17,260 --> 00:08:23,320
+الـ glucose للخلايا المختلفة. والنقطة الثالثة، the
+
+93
+00:08:23,320 --> 00:08:26,060
+ability of insulin to suppress hepatic glucose
+
+94
+00:08:26,060 --> 00:08:32,080
+production. يبقى برضه بدنا، يعني زي لأن الجلوكوز
+
+95
+00:08:32,080 --> 00:08:37,440
+عالي، بده يتوقف الكبد عن إنتاج الجلوكوز. بيبقى
+
+96
+00:08:37,440 --> 00:08:41,780
+برضه هذا بيتم اللي هو تحت تأثير الانسولين، اللي
+
+97
+00:08:41,780 --> 00:08:49,440
+بيعمل suppression لخروج الجلوكوز من الكبد. The
+
+98
+00:08:49,440 --> 00:08:52,200
+major insulin target organs are liver, skeletal
+
+99
+00:08:52,200 --> 00:08:55,500
+muscle and adipose tissue. بيهدي الـ tissues
+
+100
+00:08:55,500 --> 00:09:01,100
+المختلفة اللي بيشتغل عليها. Mainly، الـ insulin these
+
+101
+00:09:01,100 --> 00:09:03,680
+organs exhibit some differences in their
+
+102
+00:09:03,680 --> 00:09:08,500
+response to insulin. يبقى الثلاثة بيستجيبوا للـ
+
+103
+00:09:08,500 --> 00:09:14,760
+insulin، لكن الاستجابة مش متشابهة. يبقى فيه أنه بعض
+
+104
+00:09:14,760 --> 00:09:19,780
+الاختلاف في الاستجابة للـ tissues المختلفة. For
+
+105
+00:09:19,780 --> 00:09:23,120
+example، the hormone stimulates glucose uptake
+
+106
+00:09:23,120 --> 00:09:26,160
+through a specific glucose transporter، اللي هو
+
+107
+00:09:26,160 --> 00:09:32,040
+GLUT4 into muscle and fat cells، but not into liver
+
+108
+00:09:32,040 --> 00:09:37,640
+cells. يبقى الـ glucose transporters ممكن يختلف من
+
+109
+00:09:37,640 --> 00:09:43,480
+tissue إلى آخر. بينما
+
+110
+00:09:43,480 --> 00:09:46,540
+في الـ liver بتحتاج إلى transporter آخر، اللي هو
+
+111
+00:09:46,540 --> 00:09:47,800
+GLUT2.
+
+112
+00:09:49,830 --> 00:09:55,790
+طيب، نحكي شوية عن الهرمون الإنسولين، وعن الـ
+
+113
+00:09:55,790 --> 00:10:02,130
+synthesis و الـ degradation لهذا الهرمون. عبارة
+
+114
+00:10:02,130 --> 00:10:08,090
+عن خمسة آلاف وثمانية وثمانين دالتون. بروتين بتكون
+
+115
+00:10:08,090 --> 00:10:13,530
+من واحد وخمسين amino acid، وبتكون من two chains،
+
+116
+00:10:13,530 --> 00:10:21,960
+أن الـ chain A بالأحمر، وهي عندنا الـ chain B. وهذول الـ
+
+117
+00:10:21,960 --> 00:10:25,960
+two chains مرتبطين مع بعضهم البعض، اللي هو عن طريق
+
+118
+00:10:25,960 --> 00:10:33,800
+disulfide bridge. بالنسبالي
+
+119
+00:10:33,800 --> 00:10:40,010
+الـ insulin اللي موجود عند الإنسان، الـ amino acid
+
+120
+00:10:40,010 --> 00:10:43,910
+sequence للـ human insulin differs slightly from
+
+121
+00:10:43,910 --> 00:10:50,270
+insulin of other species. فينا اختلاف في بعض الـ
+
+122
+00:10:50,270 --> 00:10:58,270
+amino acids، لكن فينا مناطق متشابهة بالانسولين، سواء
+
+123
+00:10:58,270 --> 00:11:03,340
+الموجود بالإنسان أو الموجود في الـ other
+
+124
+00:11:03,340 --> 00:11:07,600
+species. The carboxyl terminal region of the B
+
+125
+00:11:07,600 --> 00:11:16,200
+chain، اللي هي المنطقة من B23 لـ B26، هذه appears
+
+126
+00:11:16,200 --> 00:11:20,420
+crucial for the biological action of insulin. ومهمة
+
+127
+00:11:20,420 --> 00:11:24,120
+للعمل للانسولين. وبالتالي هذه المنطقة highly
+
+128
+00:11:24,120 --> 00:11:29,960
+conserved among species. يبقى يعني تم اللي هو
+
+129
+00:11:29,960 --> 00:11:35,390
+المحافظة عليها، ومتشابهة في الانسولين الموجود في الـ
+
+130
+00:11:35,390 --> 00:11:40,990
+different species. بالنسبالي
+
+131
+00:11:40,990 --> 00:11:44,950
+الانسولين، insulin from most animals is
+
+132
+00:11:44,950 --> 00:11:49,610
+immunologically and biologically similar to human
+
+133
+00:11:49,610 --> 00:11:53,970
+insulin. And in the past, patients were treated with
+
+134
+00:11:53,970 --> 00:12:00,270
+insulin purified from beef or pig pancreas. لأن زي ما
+
+135
+00:12:00,270 --> 00:12:05,770
+قلنا، إن في منطقة اللي هي conserved، ويعني
+
+136
+00:12:05,770 --> 00:12:09,910
+بالتالي هذه المنطقة موجودة في different species،
+
+137
+00:12:09,910 --> 00:12:14,550
+وبالتالي تم استخدام insulin ينتج من حيوانات زي
+
+138
+00:12:14,550 --> 00:12:18,490
+اللي هو الأبقار أو اللي هو العجول أو الخنزير،
+
+139
+00:12:18,490 --> 00:12:24,570
+للمعالجة، أو للحصول على insulin لمعالجة المرضى. لكن
+
+140
+00:12:24,570 --> 00:12:29,120
+الآن طبعاً بيتم اللي هو إنتاج الإنسولين اللي هو من
+
+141
+00:12:29,120 --> 00:12:34,600
+خلال الـ recombinant اللي هو
+
+142
+00:12:34,600 --> 00:12:38,880
+DNA techniques. هيبقى عندنا اللي هو موجود اللي
+
+143
+00:12:38,880 --> 00:12:46,540
+هو recombinant human insulin. أول
+
+144
+00:12:46,540 --> 00:12:54,580
+منتج بيتم الحصول عليه، أو أول protein بيتم الحصول
+
+145
+00:12:54,580 --> 00:13:00,770
+عليه هو الـ pre-proinsulin. عبارة عن بروتين بتكون من
+
+146
+00:13:00,770 --> 00:13:05,250
+110 amino acid formed by ribosomes in the rough
+
+147
+00:13:05,250 --> 00:13:09,730
+endoplasmic reticulum of the pancreatic beta cells.
+
+148
+00:13:09,730 --> 00:13:12,870
+Pre-
+
+149
+00:13:12,870 --> 00:13:16,570
+proinsulin is not detectable in the circulation.
+
+150
+00:13:16,570 --> 00:13:23,390
+لو بحثت عن الـ pre-proinsulin، مش هنلاقيه موجود
+
+151
+00:13:23,390 --> 00:13:30,080
+في الـ circulation، بظروف طبيعية، لأن مباشرة وبشكل
+
+152
+00:13:30,080 --> 00:13:37,560
+سريع بيصير له cleavage، وبيتحول إلى proinsulin، اللي
+
+153
+00:13:37,560 --> 00:13:43,560
+عبارة عن بروتين بتكون من ثمانية وثمانين amino acid.
+
+154
+00:13:43,560 --> 00:13:47,740
+يعني أول بروتين بينتج من الـ pre-proinsulin، بيفقد
+
+155
+00:13:47,740 --> 00:13:56,690
+amino acid. مباشرة في عملية cleavage، اللي هو بيتم قطع
+
+156
+00:13:56,690 --> 00:14:00,570
+أربعة عشر amino acid، وبيعطيني proinsulin اللي هو
+
+157
+00:14:00,570 --> 00:14:04,850
+عبارة عن ثمانية وثمانين amino acid بالبروتين.
+
+158
+00:14:08,440 --> 00:14:13,600
+هذا مقفل في حويصلات مخصصة في خلايا بيتا لـ
+
+159
+00:14:13,600 --> 00:14:17,980
+beta-cells، حيث يحدث  معالجة بروتين للانسولين
+
+160
+00:14:17,980 --> 00:14:24,290
+ومشاركة بيبتيد. طبعاً، أي شيء بده يتم إفرازه من
+
+161
+00:14:24,290 --> 00:14:32,510
+الخلايا، يبقى المفروض أنه طبعاً بيبداً  بداية بيصير له translation من خلال الـ rough
+
+162
+00:14:32,510 --> 00:14:36,450
+endoplasmic reticulum، وهذا الـ protein بيكون موجود
+
+163
+00:14:36,450 --> 00:14:43,230
+في داخل حويصلة، والحويصلة ذاتها بتتجه لـ الـ
+
+164
+00:14:43,230 --> 00:14:46,950
+جهاز جولجي، اللي هو complex. وهناك اللي هو بيصير فيه عندنا
+
+165
+00:14:46,950 --> 00:14:52,320
+تعديل لهذه البروتينات. وبعدين بيصير release
+
+166
+00:14:52,320 --> 00:14:57,080
+لهذه الـ proteins في داخل حويصلات، عشان بعد هيك
+
+167
+00:14:57,080 --> 00:15:03,660
+يصلها اللي هو الإفراز إلى خارج الخلية.
+
+168
+00:15:11,740 --> 00:15:16,060
+يبقى عشان نحصل على الـ insulin، لابد أن يصير عندنا
+
+169
+00:15:16,060 --> 00:15:24,260
+cleavage للـ C-peptide. وهذا الـ cleavage بيتم من
+
+170
+00:15:24,260 --> 00:15:30,900
+خلال enzymes اللي بيتسمى prohormone convertases I
+
+171
+00:15:30,900 --> 00:15:37,880
+and II. عبارة عن endopeptidases، يبقى بيقطعوا في اللي
+
+172
+00:15:37,880 --> 00:15:45,160
+هو داخل البروتين، وبيعملوا قطع للـ C-peptide عشان
+
+173
+00:15:45,160 --> 00:15:53,160
+نحصل على الانسولين. يبقى إن الـ enzyme prohormone
+
+174
+00:15:53,160 --> 00:16:00,420
+convertase I بيجي وبيترتب على الـ C-terminal end
+
+175
+00:16:00,420 --> 00:16:12,040
+الـ  Arg 31 و Arg 32، وبيعمل قطع بين
+
+176
+00:16:12,040 --> 00:16:20,380
+الـ amino acid رقم 32 و 33، وبيعطينا
+
+177
+00:16:20,380 --> 00:16:28,680
+الـ split 32 و 33 proinsulin. عندنا
+
+179
+00:16:28,680 --> 00:16:30,880
+الـ enzyme الآخر اللي هو الـ prohormone
+
+180
+00:16:30,880 --> 00:16:35,510
+convertase-2، بيعمل cleavage في مكان آخر. Cleaves
+
+181
+00:16:35,510 --> 00:16:39,210
+proinsulin on the c-terminal side of
+
+223
+00:21:03,790 --> 00:21:15,490
+بينما الـ BC2 لُجِئَ أنه بيقطع فقط في هذه المنطقة زي
+
+224
+00:21:15,490 --> 00:21:18,450
+ما ذكرنا في الـ slider السابقة أنه في عندنا اللي
+
+225
+00:21:18,450 --> 00:21:19,590
+هو الـ minor pathway
+
+226
+00:21:22,170 --> 00:21:26,510
+وإنه less than 10% of pro-insulin is metabolized
+
+227
+00:21:26,510 --> 00:21:32,590
+via this 6465 pro-insulin which is present in
+
+228
+00:21:32,590 --> 00:21:37,250
+negligible amounts in humans المهم يا جماعة اللي هو
+
+229
+00:21:37,250 --> 00:21:41,930
+الـ minor part و بينما إن this 3132 pro-insulin is
+
+230
+00:21:41,930 --> 00:21:46,510
+the major pro-insulin conversion intermediate
+
+231
+00:21:48,760 --> 00:21:53,560
+الجلوكوز هو اللي بيتحكم بيه الـ Synthesis  لـ
+
+232
+00:21:53,560 --> 00:21:58,460
+Proinsulin و أيضًا للإنزيم اللي هو الـ PC-1 اللي
+
+233
+00:21:58,460 --> 00:22:04,180
+بيعمل القطع و تحويله اللي بيحول الـ Proinsulin إلى
+
+234
+00:22:04,180 --> 00:22:08,540
+Insulin يبقى الـ Glucose regulates biosynthesis of
+
+235
+00:22:08,540 --> 00:22:14,000
+both Proinsulin and BC-1 لكن مالهوش أي تأثير على
+
+236
+00:22:14,000 --> 00:22:21,520
+الـ BC-2 أو على الـ Carboxypeptidase H يبقى بعد ما
+
+237
+00:22:21,520 --> 00:22:24,460
+اللي هو يتمّتْ عملية القطع بعد ذلك بيصير فيه أنه
+
+238
+00:22:24,460 --> 00:22:29,800
+Exocytosis و بيصير فيه Release للإنسولين و للـ C
+
+239
+00:22:29,800 --> 00:22:30,640
+-Peptide
+
+240
+00:22:33,200 --> 00:22:40,440
+وبيدخلوا للكبد عن طريق الـ portal circulation يبقى
+
+241
+00:22:40,440 --> 00:22:44,980
+بيصير فيه inner release وبيدخلوا للدم وبيدخلوا
+
+242
+00:22:44,980 --> 00:22:49,300
+للكبد عن طريق الـ portal circulation و بعدين طبعًا
+
+243
+00:22:49,300 --> 00:22:54,760
+بيصلوا إلى جميع أجزاء الجسم
+
+244
+00:22:56,750 --> 00:23:01,410
+بالإضافة للإنسولين والـ C-peptide برضه بنلاقي
+
+245
+00:23:01,410 --> 00:23:06,110
+small amounts of pro-insulin ومن الـ intermediate
+
+246
+00:23:06,110 --> 00:23:12,970
+cleavage forms هدول بنلاقيهم برضه موجودين في الـ
+
+247
+00:23:12,970 --> 00:23:17,250
+circulation طيب،
+
+248
+00:23:17,250 --> 00:23:21,470
+إيش الـ stimulus أو الـ signal اللي بتؤدي إلى الـ
+
+249
+00:23:21,470 --> 00:23:26,700
+release of insulin؟ الجلوكوز is the most important
+
+250
+00:23:26,700 --> 00:23:32,800
+physiological secretagogue for
+
+251
+00:23:32,800 --> 00:23:37,700
+insulin يبقى هو الـ substance that promotes
+
+252
+00:23:37,700 --> 00:23:41,060
+secretion of insulin الجلوكوز substance that
+
+253
+00:23:41,060 --> 00:23:45,600
+promotes the secretion of insulin يبقى الزيادة
+
+254
+00:23:45,600 --> 00:23:52,140
+في مستوى الجلوكوز بيعمل stimulation للـ beta
+
+255
+00:23:52,140 --> 00:23:57,680
+cells عشان تعمل اللي هو secretion للإنسولين وهذا
+
+256
+00:23:57,680 --> 00:24:01,140
+بيصير within minutes insulin release is
+
+257
+00:24:01,140 --> 00:24:06,420
+potentiated by substances such as the incretin
+
+258
+00:24:06,420 --> 00:24:13,680
+hormones يعني إن في شغلات برضه هذه بتزيد من إفراز
+
+259
+00:24:14,120 --> 00:24:17,560
+الإنسولين زي عندنا الـ incretin hormones عبارة عن
+
+260
+00:24:17,560 --> 00:24:23,980
+مجموعة من الهرمونات اللي بيصير لها release بعد الأكل
+
+261
+00:24:23,980 --> 00:24:29,200
+بسبب هذه الهرمونات لما الإنسان بيتناول اللي هو الطعام
+
+262
+00:24:29,200 --> 00:24:34,220
+بيصير فيه عندنا release للـ incretin hormones زي
+
+263
+00:24:34,220 --> 00:24:37,440
+اللي هو الـ glucagon-like peptide و الـ glucose
+
+264
+00:24:37,440 --> 00:24:41,320
+-dependent insulinotropic polypeptide
+
+265
+00:24:42,100 --> 00:24:49,440
+و«كوليسيستوكاينين، بيبتايد YY» و«إكزينتوموديولين»
+
+266
+00:24:49,440 --> 00:24:53,100
+كلها هذه هرمونات بس اللي بيصير لها release بعد تناول
+
+267
+00:24:53,100 --> 00:25:00,380
+الطعام وهذه الهرمونات كلها بتزيد من الـ release
+
+268
+00:25:00,380 --> 00:25:02,300
+للإنسولين
+
+269
+00:25:04,000 --> 00:25:07,940
+في المقابل، إن العديد من العوامل اللي بتعمل
+
+270
+00:25:07,940 --> 00:25:12,220
+Inhibition لـ Insulin Release ومنها الـ
+
+271
+00:25:12,220 --> 00:25:17,000
+Hypoglycemia يعني انخفاض في مستوى الـ Glucose إنه
+
+272
+00:25:17,000 --> 00:25:21,760
+الـ Somatostatin اللي بيفرز برضه في الـ Pancreas
+
+273
+00:25:21,760 --> 00:25:26,440
+من خلال الـ Delta Cells الموجودة في الـ Pancreas
+
+274
+00:25:26,710 --> 00:25:32,010
+هذا الـ hormone بيعمل اللي هو inhibition على الـ
+
+275
+00:25:32,010 --> 00:25:36,030
+beta cells وبالتالي بيقلل أو بيعمل inhibition للـ
+
+276
+00:25:36,030 --> 00:25:42,650
+release للإنسولين بالإضافة للعديد من الـ drugs اللي
+
+277
+00:25:42,650 --> 00:25:47,770
+ممكن بتعمل inhibition للـ release للإنسولين من
+
+278
+00:25:47,770 --> 00:25:52,030
+خلال تأثيرها على الـ beta cells
+
+279
+00:25:58,690 --> 00:26:01,690
+in healthy individuals insulin is released in a
+
+280
+00:26:01,690 --> 00:26:05,610
+pulsatile fashion يبقى بيكون اللي هو عن طريق اللي
+
+281
+00:26:05,610 --> 00:26:11,050
+هو pulses  يبقى عندنا كل فترة بيصير في release
+
+282
+00:26:11,050 --> 00:26:15,210
+لكمية من الـ insulin يبقى في عندنا pulsatile
+
+283
+00:26:15,210 --> 00:26:20,620
+release، pulses with glucose and insulin the main
+
+284
+00:26:20,620 --> 00:26:25,140
+signals in the feedback loop يبقى هم اللي .. و
+
+285
+00:26:25,140 --> 00:26:28,780
+اللي بتحكمه و اللي بيعملوا اللي هو feedback أو
+
+286
+00:26:28,780 --> 00:26:31,240
+negative feedback على الـ .. الـ release اللي
+
+287
+00:26:31,240 --> 00:26:35,500
+glucose و الـ insulin الـ glucose اللي sets the
+
+288
+00:26:35,500 --> 00:26:39,000
+release of insulin from the pancreas into phases
+
+289
+00:26:39,000 --> 00:26:46,220
+يبقى لما بيدخل الـ glucose للدم بيصير فيه أنا
+
+290
+00:26:46,220 --> 00:26:52,210
+release للـ insulin على مرحلتين أو على مرحلتين
+
+291
+00:26:52,210 --> 00:27:01,410
+المرحلة الأولى بتبدأ بعد دقيقة إلى دقيقتين من دخول
+
+292
+00:27:01,410 --> 00:27:09,310
+الـ glucose للدم و بتنتهي عند عشر دقائق المرحلة
+
+293
+00:27:09,310 --> 00:27:13,330
+الأولى بتبدأ يعني بشكل سريع بعد دقيقة أو دقيقتين
+
+294
+00:27:13,890 --> 00:27:18,590
+وبتنتهي عند عشر دقائق وبهذه المرحلة بيكون في عندنا
+
+295
+00:27:18,590 --> 00:27:23,190
+release لكمية كبيرة من الإنسولين يبقى sharp spike
+
+296
+00:27:23,190 --> 00:27:29,130
+represents the rapid release of stored insulin يبقى
+
+297
+00:27:29,130 --> 00:27:34,290
+بيصير release لكمية كبيرة من الإنسولين بعد هيك
+
+298
+00:27:34,290 --> 00:27:38,070
+بتدخل المرحلة الثانية beginning at the point where
+
+299
+00:27:38,070 --> 00:27:44,010
+the first phase ended بتبدأ بعد العشر دقائق وبتستمر
+
+300
+00:27:44,010 --> 00:27:50,030
+لغاية ما يرجع مستوى الـ glucose في الدم إلى
+
+301
+00:27:50,030 --> 00:27:58,570
+المستوى الطبيعي وهذه ممكن تستمر يعني لمدة 60 إلى
+
+302
+00:27:58,570 --> 00:28:08,940
+120 دقيقة أو يعني تنتهي بعد 60 إلى 120 دقيقة هذا
+
+303
+00:28:08,940 --> 00:28:15,200
+الـ figure بيوضح استجابة أو
+
+304
+00:28:15,200 --> 00:28:20,060
+الـ concentration للـ إنسولين بناء على الـ
+
+305
+00:28:20,060 --> 00:28:28,060
+injection لجلوكوز في الدم يبين هنا إنه كمية
+
+306
+00:28:28,060 --> 00:28:34,720
+الإنسولين اللي صارت لها detection في الدم و هنا إنه الـ
+
+307
+00:28:34,720 --> 00:28:42,190
+time هنا إن هو شخص طبيعي وزي ما قلنا إنه بيصير فيه
+
+308
+00:28:42,190 --> 00:28:48,750
+إني release للإنسولين على مرحلتين هنا اللي هو كمية
+
+309
+00:28:48,750 --> 00:28:54,310
+الإنسولين قبل ما يتم حقن الشخص بعشرين جرامًا من الـ
+
+310
+00:28:54,310 --> 00:28:59,630
+glucose هنا عند صفر صار إن عملية الحقن زي ما احنا
+
+311
+00:28:59,630 --> 00:29:03,990
+شايفين أنه بتبدأ عندنا الـ phase one المرحلة الأولى
+
+312
+00:29:03,990 --> 00:29:07,930
+زي ما قلنا خلال دقيقة إلى دقيقتين بيصير في عندي الـ
+
+313
+00:29:07,930 --> 00:29:14,730
+release للـ اللي هو كمية كبيرة من الـ insulin بعد هيك
+
+314
+00:29:14,730 --> 00:29:18,050
+بعد وهذه بتستمر لتقريبًا عشر دقائق بعد هيك بتبدأ
+
+315
+00:29:18,050 --> 00:29:22,850
+عندي الـ concentration للـ insulin بتقل بنبدأ بيه
+
+316
+00:29:22,850 --> 00:29:27,670
+المرحلة الثانية كل ما نزل الـ glucose concentration
+
+317
+00:29:27,670 --> 00:29:33,650
+كل ما قلت كمية الـ insulin الموجودة لغاية ما ترجع
+
+318
+00:29:33,650 --> 00:29:39,070
+كمية اللي هو الـ insulin للـ basal levels عندما
+
+319
+00:29:39,070 --> 00:29:44,940
+ترجع اللي هو الـ concentration للـ glucose للمستوى
+
+320
+00:29:44,940 --> 00:29:50,860
+الطبيعي الـ figures الثانية اللي هو إنّها figure B
+
+321
+00:29:50,860 --> 00:29:57,780
+هذا بيوضح كمية الـ insulin عند شخص مصاب بالـ type 2
+
+322
+00:29:57,780 --> 00:30:01,640
+diabetes mellitus و الناس المصابين بالـ type 2
+
+323
+00:30:01,640 --> 00:30:07,040
+diabetes mellitus بيفقدوا phase one بيكونش موجود
+
+324
+00:30:07,040 --> 00:30:13,730
+عندهم phase one عشان هيك لما بيتناولوا الـ
+
+325
+00:30:13,730 --> 00:30:18,610
+carbohydrates وبيدخل الجلوكوز للدم بنلاقي أنه بيظل
+
+326
+00:30:18,610 --> 00:30:23,150
+الـ الـ الـ glucose concentration مرتفعة فترة
+
+327
+00:30:23,150 --> 00:30:28,430
+طويلة في الدم لأنه الـ phase one المرحلة الأولى
+
+328
+00:30:28,430 --> 00:30:34,470
+مهمة ليه اللي هو خفض مستوى السكر بسرعة لأن زي ما
+
+329
+00:30:34,470 --> 00:30:38,070
+قلنا بيصير release لكمية كبيرة من الإنسولين واللي
+
+330
+00:30:38,070 --> 00:30:44,370
+هو بشكل سريع لكن الـ type two الـ diabetic patients
+
+331
+00:30:44,370 --> 00:30:48,730
+الـ phase one مش موجودة عندهم يعني هنا عند صفر
+
+332
+00:30:48,730 --> 00:30:53,330
+صار فيه عندي اللي هو injection لعشرين جرامًا من
+
+333
+00:30:53,330 --> 00:30:57,210
+الجلوكوز زي ما احنا شايفين أنه مافيش عندنا spike
+
+334
+00:30:57,210 --> 00:31:01,770
+زي ما صار هنا يبقى الـ phase one مش موجودة لكن
+
+335
+00:31:01,770 --> 00:31:08,150
+الـ phase two موجودة بيبدأ يرتفع عندنا الـ insulin
+
+336
+00:31:11,130 --> 00:31:18,650
+و زي ما حكينا إنه هذا بياخذ يعني فترات طويلة
+
+337
+00:31:18,650 --> 00:31:27,430
+للوصول إلى الـ normal concentration يعني
+
+338
+00:31:27,430 --> 00:31:30,270
+لأ طبعًا بالـ type 2 diabetes مش هيصل للـ normal
+
+339
+00:31:30,270 --> 00:31:34,670
+يعني عشان يخفض الـ glucose لكن طبعًا مش هيصل للـ
+
+340
+00:31:34,670 --> 00:31:41,520
+normal هيظل عندنا الـ glucose مرتفع بينما في الـ
+
+341
+00:31:41,520 --> 00:31:45,920
+patients with type 1 طبعًا إنّ المشكلة أصلاً احنا في
+
+342
+00:31:45,920 --> 00:31:52,280
+الـ release of insulin لأنه عندنا اللي هو صار فيه
+
+343
+00:31:52,280 --> 00:31:56,040
+destruction لـ beta cells وبالتالي يعني الـ
+
+344
+00:31:56,040 --> 00:31:59,720
+insulin مش موجود أو موجود يعني بـ very low
+
+345
+00:31:59,720 --> 00:32:00,860
+concentrations
+
+346
+00:32:03,380 --> 00:32:06,720
+يبقى زي ما شوفنا في الـ figure السابق with
+
+347
+00:32:06,720 --> 00:32:09,360
+progressive failure of beta cell function first
+
+348
+00:32:09,360 --> 00:32:15,740
+phase insulin response للجلوكوز is lost لكن إن الـ
+
+349
+00:32:15,740 --> 00:32:21,060
+second phase بتظل اللي موجودة is preserved both
+
+350
+00:32:21,060 --> 00:32:23,520
+the first phase response and normal pulsatile
+
+351
+00:32:23,520 --> 00:32:26,760
+insulin secretion are lost يبقى الـ first phase
+
+352
+00:32:26,760 --> 00:32:32,790
+بيفقد الـ pulsatile insulin secretion  لكن الـ
+
+353
+00:32:32,790 --> 00:32:39,550
+second phase بتظل موجودة وطبعًا الـ word type one
+
+354
+00:32:39,550 --> 00:32:44,510
+أنه أصلاً مشكلة في الـ release للإنسولين وبالتالي
+
+355
+00:32:44,510 --> 00:32:50,110
+minimal or no insulin response النقطة التالية الـ
+
+356
+00:32:50,110 --> 00:32:51,750
+insulin degradation
+
+357
+00:32:56,300 --> 00:32:58,660
+على الطريق الأول من خلال الـ Portal Circulation
+
+358
+00:32:58,660 --> 00:33:04,300
+نحن زي ما قلنا أنه بيصير فيه إطلاق للإنسولين بيدخل
+
+359
+00:33:04,300 --> 00:33:09,160
+للكبد عن طريق الـ Portal Circulation يبقى عندنا
+
+360
+00:33:09,160 --> 00:33:12,040
+الطريق الأول من خلال الـ Portal Circulation
+
+361
+00:33:12,040 --> 00:33:20,050
+تقريبًا 50% من الإنسولين يتم إخراجه من الكبد يعني
+
+362
+00:33:20,050 --> 00:33:25,530
+where it is degraded يعني مش ممكن الـ .. يعني مش كل
+
+363
+00:33:25,530 --> 00:33:29,030
+الكمية ممكن تستخدم  الـ degradation يعني ممكن يصير
+
+364
+00:33:29,030 --> 00:33:32,950
+فيه فعليًا extraction لخمسين بالمية من الإنسولين
+
+365
+00:33:32,950 --> 00:33:41,390
+لكن ممكن يصير لاحقًا release لبعض من هذه الكمية
+
+366
+00:33:41,390 --> 00:33:46,630
+مرة أخرى للـ circulation هو يعني مش كتير دقيق إنّه
+
+367
+00:33:46,990 --> 00:33:51,570
+الخمسين بالمية هذه بيصير لها degradation يبقى بيصير
+
+368
+00:33:51,570 --> 00:33:55,410
+فيه extraction لخمسين بالمية من الإنسولين لكن ممكن
+
+369
+00:33:55,410 --> 00:33:59,930
+لاحقًا بعض من هذه الكمية اللي صارت لها الـ extraction
+
+370
+00:33:59,930 --> 00:34:04,190
+ممكن ترجع تدخل للـ circulation مرة أخرى
+
+371
+00:34:04,190 --> 00:34:07,370
+additional insulin degradation occurs in the
+
+372
+00:34:07,370 --> 00:34:12,300
+kidneys وعملية الـ degradation ها بتصير في الـ
+
+373
+00:34:12,300 --> 00:34:17,280
+tubules وبالـ proximal tubules بشكل خاص يبقى
+
+374
+00:34:17,280 --> 00:34:21,580
+بيصير فيه عندنا filtration للإنسولين عن طريق الـ
+
+375
+00:34:21,580 --> 00:34:27,760
+glomeruli بعد هيك بيصير فيه reabsorption للإنسولين
+
+376
+00:34:27,760 --> 00:34:31,520
+في الـ proximal convoluted tubule وبتصير
+
+377
+00:34:31,520 --> 00:34:37,000
+degradation للإنسولين في داخل خلايا الـ proximal
+
+378
+00:34:37,000 --> 00:34:38,620
+convoluted tubule
+
+379
+00:35:01,390 --> 00:35:07,330
+بنسبة له الـ Proinsulin بشكل طبيعي إنها عدد صغير
+
+380
+00:35:09,190 --> 00:35:13,870
+of proinsulin enters the circulation لتقريبًا ثلاثة
+
+381
+00:35:13,870 --> 00:35:18,310
+بالمية of the amount of insulin بتلاتة بالمية من
+
+382
+00:35:18,310 --> 00:35:21,230
+كمية الـ insulin اللي بتدخل اللي هو عندنا بتكون
+
+383
+00:35:21,230 --> 00:35:25,830
+عبارة عن الـ proinsulin لكن بالنسبة للـ proinsulin
+
+384
+00:35:25,830 --> 00:35:29,310
+the hepatic clearance rate for proinsulin is only
+
+385
+00:35:29,310 --> 00:35:34,630
+25% of that for insulin يعني عندنا الـ clearance
+
+386
+00:35:34,630 --> 00:35:41,940
+أقل مقارنة بالإنسولين وبالمقابل أيضًا الـ half-life
+
+387
+00:35:41,940 --> 00:35:47,260
+لـ الـ Proinsulin تقريبًا ثلاثين دقيقة يبقى الـ
+
+388
+00:35:47,260 --> 00:35:50,320
+clearance اللي صارت له  الـ clearance أقل مقارنة
+
+389
+00:35:50,320 --> 00:35:54,400
+بالإنسولين الـ half-life للـ Proinsulin أعلى
+
+390
+00:35:54,400 --> 00:36:01,320
+تقريبًا بست مرات من الإنسولين وبالتالي خلال اللي هو
+
+391
+00:36:01,320 --> 00:36:04,420
+الـ fasting state ممكن نلاقي إن الـ circulating
+
+392
+00:36:04,420 --> 00:36:10,100
+pro-insulin concentration approximately 10% to 15%
+
+393
+00:36:10,100 --> 00:36:15,800
+of insulin concentration اللي هو بسبب .. زي ما
+
+394
+00:36:15,800 --> 00:36:21,500
+ذكرنا السببين إنه الـ clearance أقل في الكبد و الـ
+
+395
+00:36:21,500 --> 00:36:28,120
+half-life أطول بالنسبة
+
+396
+00:36:28,120 --> 00:36:29,680
+للـ C-peptide
+
+397
+00:36:32,210 --> 00:36:34,850
+was initially thought to be devoid of biological
+
+398
+00:36:34,850 --> 00:36:38,950
+activity وكانوا بالـ .. بالأول بيفكروا أنه مافيش أي
+
+399
+00:36:38,950 --> 00:36:45,950
+وظيفة مهمة للـ C-peptide and
+
+400
+00:36:45,950 --> 00:36:48,510
+was necessary only to ensure the correct structure
+
+401
+00:36:48,510 --> 00:36:57,150
+of insulin لكن من خلال أبحاث اللي تمّت على الـ C
+
+402
+00:36:57,150 --> 00:36:59,770
+-peptide لُجِئَ إنّ الـ C-peptide له بيولوجيكال
+
+403
+00:36:59,770 --> 00:37:02,550
+activity but its possible physiological
+
+404
+00:37:02,550 --> 00:37:07,010
+significance remains controversial يعني مافيش لسه
+
+405
+00
\ No newline at end of file
diff --git a/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/_h2KNL9Vj6A_postprocess.srt b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/_h2KNL9Vj6A_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..04da9b140024c23f34a46717f4dccf5c3c865f95
--- /dev/null
+++ b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/_h2KNL9Vj6A_postprocess.srt
@@ -0,0 +1,1752 @@
+1
+00:00:02,870 --> 00:00:07,210
+Categories of increased risk for diabetes بيقنّا
+
+2
+00:00:07,210 --> 00:00:12,410
+الفئات اللي احتمالية الإصابة بيه الـ diabetes
+
+3
+00:00:12,410 --> 00:00:18,710
+عندهم أعلى أول شيء بيقنّا impaired glucose
+
+4
+00:00:18,710 --> 00:00:22,330
+tolerance people who have blood glucose
+
+5
+00:00:22,330 --> 00:00:26,490
+concentrations above normal but less than those
+
+6
+00:00:26,490 --> 00:00:33,290
+required for diagnosis of diabetes malitusوهذا
+
+7
+00:00:33,290 --> 00:00:43,410
+اللي .. اللي هو مرتبط بقياس للجلوكوز عن طريق اللي
+
+8
+00:00:43,410 --> 00:00:48,890
+هو الـ Oral Glucose Tolerance Test وعنا
+
+9
+00:00:48,890 --> 00:00:55,650
+القياس لجلوكوز بعد ساعتين من إعطاء اللي هو الجرعة
+
+10
+00:00:55,650 --> 00:01:01,580
+لجلوكوز بيكون بين مية وأربعين إلى مية تسعةو
+
+11
+00:01:01,580 --> 00:01:06,260
+التسعين طبعا بهذا الحالة يعني ما نقدرش نقول أن هذا
+
+12
+00:01:06,260 --> 00:01:11,420
+عنده diabetes mellitus لأن عشان نقول أنه عنده
+
+13
+00:01:11,420 --> 00:01:14,480
+diabetes mellitus المفروض يكون ال glucose
+
+14
+00:01:14,480 --> 00:01:22,260
+concentration أكتر من 200 و ال normal أقل من 140
+
+15
+00:01:22,260 --> 00:01:28,990
+لأ هو مع ال normal ولا هومع الأشخاص اللي مصابين
+
+16
+00:01:28,990 --> 00:01:34,650
+بالسكري، في 140 ل 199 هذا الشخص بيكون عنده ما يسمى
+
+17
+00:01:34,650 --> 00:01:41,270
+بالـ Impaired Glucose Tolerance أو اللي بنسميهم أو
+
+18
+00:01:41,270 --> 00:01:46,010
+بنسمي المرحلة هذه يعني Pre-diabetes اللي هي مرحلة
+
+19
+00:01:46,010 --> 00:01:48,490
+ما قبل السكري
+
+20
+00:01:53,340 --> 00:01:55,620
+لتخلص من جلوكوز صحيح صحيح الصحيح الصحيح الصحيح
+
+21
+00:01:55,620 --> 00:01:56,320
+الصحيح الصحيح الصحيح الصحيح الصحيح الصحيح الصحيح
+
+22
+00:01:56,320 --> 00:02:02,000
+الصحيح الصحيح الصحيح الصحيح الصحيح الصحيح الصحيح
+
+23
+00:02:02,000 --> 00:02:02,780
+الصحيح الصحيح الصحيح الصحيح الصحيح الصحيح الصحيح
+
+24
+00:02:02,780 --> 00:02:07,560
+الصحيح الصحيح الصحيح الصحيح الصحيح الصحيح الصحيح
+
+25
+00:02:07,560 --> 00:02:08,040
+الصحيح الصحيح الصحيح الصحيح الصحيح الصحيح الصحيح
+
+26
+00:02:08,040 --> 00:02:08,300
+الصحيح الصحيح الصحيح الصحيح الصحيح الصحيح الصحيح
+
+27
+00:02:08,300 --> 00:02:13,500
+الصحيح الصحيح الصحيح الصحيح الصحيح الصحيحبعد هيك
+
+28
+00:02:13,500 --> 00:02:16,160
+يعني عشان يتجنبوا استخدام الـ oral glucose
+
+29
+00:02:16,160 --> 00:02:21,260
+tolerance test صار في عندنا اللي هو اللي هي
+
+30
+00:02:21,260 --> 00:02:24,780
+category أو مصطلح آخر اللي يسمى impaired fasting
+
+31
+00:02:24,780 --> 00:02:29,540
+glucose و
+
+32
+00:02:29,540 --> 00:02:35,540
+هذه تم إضافتها طبعا عن طريق ال ADA ال American
+
+33
+00:02:35,540 --> 00:02:42,270
+Wadiabeta Associationولاحقاً برضه تم إضافتها من
+
+34
+00:02:42,270 --> 00:02:49,510
+خلال الـ WHO في العام تسعة وتسعين الـ
+
+35
+00:02:49,510 --> 00:02:52,310
+impaired fasting glucose diagnosed by fasting
+
+36
+00:02:52,310 --> 00:02:55,590
+glucose value between those of normal and diabetic
+
+37
+00:02:55,590 --> 00:03:01,330
+individuals وها برضه نفس ال issueالمفروض الشخص
+
+38
+00:03:01,330 --> 00:03:05,110
+طبيعي إذا كان ال glucose عنده طبعا احنا بنحكي على
+
+39
+00:03:05,110 --> 00:03:10,910
+glucose لشخص صايم ال glucose بدي يكون طبيعي إذا
+
+40
+00:03:10,910 --> 00:03:16,410
+كان أقل من مية و بدي يكون عنده diabetes إذا كان ال
+
+41
+00:03:16,410 --> 00:03:21,030
+concentration أكتر من 126 يبقى ال concentration
+
+42
+00:03:21,030 --> 00:03:27,800
+هان بين ميةوالـ 125 ميلي جرام per ديسليتر وبالتالي
+
+43
+00:03:27,800 --> 00:03:32,580
+لا هو normal ولا هو diabetic برضه هذه المرحلة اللي
+
+44
+00:03:32,580 --> 00:03:36,280
+هو بنسميها pre-diabetes بمرحلة الـ pre-diabetes
+
+45
+00:03:36,280 --> 00:03:41,420
+ممكن انشخصها من خلال استخدام الـ Oral Glucose
+
+46
+00:03:41,420 --> 00:03:45,840
+Tolerance Test وزي ما قلنا اللي هو بعد ساعتين
+
+47
+00:03:45,840 --> 00:03:52,030
+بديكون عندنا ال concentration بين 140 ل 199أو من
+
+48
+00:03:52,030 --> 00:03:58,590
+خلال فحص الجلوكوز لشخص صايم وبتكون الـ
+
+49
+00:03:58,590 --> 00:04:05,910
+concentration بين 100 إلى 125 طبعا
+
+50
+00:04:05,910 --> 00:04:08,930
+هذه ال .. ال concentration اللي هو 100 إلى 125
+
+51
+00:04:08,930 --> 00:04:14,770
+بناء على ال American Diabetes Association لكن
+
+52
+00:04:14,770 --> 00:04:22,450
+بالنسبة للـ WHO الأرقام مختلفةوالـ WHO بتعتبر أنه
+
+53
+00:04:22,450 --> 00:04:30,710
+ال cut-off value لال .. اللي هو ال normal 110 ومش
+
+54
+00:04:30,710 --> 00:04:36,810
+100 وبالتالي إذا كان أن الشخص ال concentration لال
+
+55
+00:04:36,810 --> 00:04:41,270
+glucose ال fasting اللي هو ال glucose من 110 ل125
+
+56
+00:04:42,940 --> 00:04:47,440
+بناء طبعا على اللي هو ال WHO يبقى بنقول أن هذا
+
+57
+00:04:47,440 --> 00:04:58,420
+الشخص عنده pre diabetes في
+
+58
+00:04:58,420 --> 00:05:04,880
+2009 تم إضافة اللي هو فحص آخر اللي
+
+59
+00:05:04,880 --> 00:05:09,280
+اللي هو برضه ال detection of pre diabetes status
+
+60
+00:05:09,280 --> 00:05:11,660
+اللي هو ال hemoglobin A1C
+
+61
+00:05:14,730 --> 00:05:19,910
+الناس مع قيمة Hemoglobin A1C تحت قطع 4 ديابتا الى
+
+62
+00:05:19,910 --> 00:05:24,890
+6.5 ولكن أعلى مقارنة الانترال هم في حرص عالي
+
+63
+00:05:24,890 --> 00:05:32,270
+للتطور من ديابتا إذا كان ال Hemoglobin A1C أعلى من
+
+64
+00:05:32,270 --> 00:05:38,070
+6.5 معناته هذا الشخص دياباتيك
+
+65
+00:05:39,420 --> 00:05:45,840
+وإذا أقل من 5.7 normal يبقى إذا كان فحصنا الـ
+
+66
+00:05:45,840 --> 00:05:50,860
+hemoglobin A1C ولاجيناها بين 5.7 على 6.4 يبقى برضه
+
+67
+00:05:50,860 --> 00:05:56,020
+هذا اللي هو الشخص اللي في مرحلة الـ pre-diabetes
+
+68
+00:05:56,020 --> 00:06:03,480
+وعنده ال risk عالي للإصابة بالـ diabetes يبقى
+
+69
+00:06:03,480 --> 00:06:09,390
+عندنا أكتر من فحص ممكن يتم استخدامهمو ممكن من
+
+70
+00:06:09,390 --> 00:06:16,010
+خلالهم نحدد الناس اللي يعني أكتر عرضة أو at higher
+
+71
+00:06:16,010 --> 00:06:22,250
+risk للإصابة بالـ diabetes بالنسبالي
+
+72
+00:06:22,250 --> 00:06:28,870
+الهرمونات اللي بتنظم مستوى ال blood glucose في
+
+73
+00:06:28,870 --> 00:06:34,680
+عندنا نوعين من الهرمونات في عندناالـ Hypoglycemic
+
+74
+00:06:34,680 --> 00:06:41,360
+Hormones وفينا الـ Hyperglycemic Hormones الـ
+
+75
+00:06:41,360 --> 00:06:45,680
+Hypoglycemic Hormones طبعا إنها هرمون وحيد هو الـ
+
+76
+00:06:45,680 --> 00:06:50,620
+Insulin بهذا الهرمون الوحيد اللي بيعمل على تخفيد
+
+77
+00:06:50,620 --> 00:06:55,740
+مستوى الجلوكوز في الدم بينما الـ Hyperglycemic
+
+78
+00:06:55,740 --> 00:07:02,610
+Hormones إنها هرمونات عديدة بتعمل على رفعمستوى
+
+79
+00:07:02,610 --> 00:07:08,410
+الجلوكوز في الدم زي عندنا طبعا ال glucagon ال
+
+80
+00:07:08,410 --> 00:07:13,990
+epinephrine عندنا ال growth hormone ال cortisol
+
+81
+00:07:13,990 --> 00:07:19,550
+بيادة كلها هرمونات بتعمل على زيادة مستوى الجلوكوز
+
+82
+00:07:19,550 --> 00:07:21,190
+في الدم
+
+83
+00:07:30,410 --> 00:07:37,970
+Normal glucose disposal depends on يبقى عشان ال ..
+
+84
+00:07:37,970 --> 00:07:44,890
+ال glucose اللي بيدخله الدم عشان نقدر نخفضه يبقى
+
+85
+00:07:44,890 --> 00:07:51,090
+لابد انه يكون عندنا الأمور التالية الأمر الأول the
+
+86
+00:07:51,090 --> 00:07:55,250
+ability of the pancreas to secrete insulin يبقى
+
+87
+00:07:55,250 --> 00:07:58,090
+لازم يكون فيه قدرة لقى ال pancreas طبعا على إفراز
+
+88
+00:07:58,090 --> 00:08:02,540
+ال insulinوالنقطة التانية ability of insulin to
+
+89
+00:08:02,540 --> 00:08:06,100
+promote uptake of glucose into peripheral tissue
+
+90
+00:08:06,100 --> 00:08:11,000
+يبقى النقطة التانية اللي هو انه ال insulin action
+
+91
+00:08:11,000 --> 00:08:17,260
+يرتبط ال insulin مع الخلايا وفعليا يعمل على دخول
+
+92
+00:08:17,260 --> 00:08:23,320
+ال glucose للخلايا المختلفة والنقطة التالتة the
+
+93
+00:08:23,320 --> 00:08:26,060
+ability of insulin to suppress hepatic glucose
+
+94
+00:08:26,060 --> 00:08:32,080
+production يبقى برضهبدناش يعني زي لأن الجلوكوز
+
+95
+00:08:32,080 --> 00:08:37,440
+عالي بيبدناه يتوقف الكبد عن إنتاج الجلوكوز بيبقى
+
+96
+00:08:37,440 --> 00:08:41,780
+برضه هذا بيتم اللي هو تحت تأثير الانسولين اللي
+
+97
+00:08:41,780 --> 00:08:49,440
+بيعمل suppression لخروج الجلوكوز من الكبد the
+
+98
+00:08:49,440 --> 00:08:52,200
+major insulin target organs are liver, skeletal
+
+99
+00:08:52,200 --> 00:08:55,500
+muscle and adipose tissue بيهدي ال tissues
+
+100
+00:08:55,500 --> 00:09:01,100
+المختلفة اللي بيشتغل عليهاmainly ال insulin these
+
+101
+00:09:01,100 --> 00:09:03,680
+organs is exhibit some differences in their
+
+102
+00:09:03,680 --> 00:09:08,500
+response to insulin يبقى التلاتة بيستجيبوا لال
+
+103
+00:09:08,500 --> 00:09:14,760
+insulin لكن الاستجابة مش متشابهة يبقى فيه انه بعض
+
+104
+00:09:14,760 --> 00:09:19,780
+الاختلاف في الاستجابة لال tissuesالمختلفة for
+
+105
+00:09:19,780 --> 00:09:23,120
+example the hormone stimulates glucose uptake
+
+106
+00:09:23,120 --> 00:09:26,160
+through a specific glucose transporter اللي هو
+
+107
+00:09:26,160 --> 00:09:32,040
+glut4 into muscle and fat cells but not into liver
+
+108
+00:09:32,040 --> 00:09:37,640
+cells يبقى ال glucose transporters ممكن يختلف من
+
+109
+00:09:37,640 --> 00:09:43,480
+tissue إلى آخر بينما
+
+110
+00:09:43,480 --> 00:09:46,540
+في ال liver تحتاج إلى transporter آخر اللي هو
+
+111
+00:09:46,540 --> 00:09:47,800
+glut2
+
+112
+00:09:49,830 --> 00:09:55,790
+طيب نحكي شوية عن ال hormone الانسولين و عن ال
+
+113
+00:09:55,790 --> 00:10:02,130
+synthesis و ال degradation لهذا ال hormone عبارة
+
+114
+00:10:02,130 --> 00:10:08,090
+عن خمس تلاف و تمانية و تمانية دالتون بروتين بتكون
+
+115
+00:10:08,090 --> 00:10:13,530
+من واحد و خمسين amino acid و بتكون من two chains
+
+116
+00:10:13,530 --> 00:10:21,960
+ان ال chain Aبالأحمر وهي عندنا ال chain B وهدول ال
+
+117
+00:10:21,960 --> 00:10:25,960
+two chains مرتبطين مع بعضهم البعض اللي هو عن طريق
+
+118
+00:10:25,960 --> 00:10:33,800
+disulfide bridge بالنسبالي
+
+119
+00:10:33,800 --> 00:10:40,010
+ال insulin اللي موجود عند الإنسانالـ amino acid
+
+120
+00:10:40,010 --> 00:10:43,910
+sequence لالـ human insulin differs slightly from
+
+121
+00:10:43,910 --> 00:10:50,270
+insulin of other species فينا اختلاف في لوباط ال
+
+122
+00:10:50,270 --> 00:10:58,270
+amino acids لكن فينا مناطق متشابهة بالانسولين سواء
+
+123
+00:10:58,270 --> 00:11:03,340
+الموجود بالإنسان أو الموجود فياللي هو other
+
+124
+00:11:03,340 --> 00:11:07,600
+species the carboxyl terminal region of the B
+
+125
+00:11:07,600 --> 00:11:16,200
+chain اللي هي المنطقة من B23 ل B26 هذه appears
+
+126
+00:11:16,200 --> 00:11:20,420
+crucial for the biological action of insulin ومهمة
+
+127
+00:11:20,420 --> 00:11:24,120
+العمل للإنسلين وبالتالي هذه المنطقة highly
+
+128
+00:11:24,120 --> 00:11:29,960
+conserved among species يبقى يعني تم اللي هو
+
+129
+00:11:29,960 --> 00:11:35,390
+المحافظة عليها ومتشابهةفي الانسلين الموجود في ال
+
+130
+00:11:35,390 --> 00:11:40,990
+different species بنسبالها
+
+131
+00:11:40,990 --> 00:11:44,950
+الانسلين senses انسلين from most animals is
+
+132
+00:11:44,950 --> 00:11:49,610
+immunologically and biologically similar to human
+
+133
+00:11:49,610 --> 00:11:53,970
+insulin and in the past patients were treated with
+
+134
+00:11:53,970 --> 00:12:00,270
+insulin purified from beef or pig cancersلأن زي ما
+
+135
+00:12:00,270 --> 00:12:05,770
+قلنا إن في منطقة اللي هي conserved ويعني
+
+136
+00:12:05,770 --> 00:12:09,910
+بالتالي المنطقة هذه موجودة بال different species
+
+137
+00:12:09,910 --> 00:12:14,550
+وبالتالي تم استخدام insulin بينتج من حيوانات زي
+
+138
+00:12:14,550 --> 00:12:18,490
+اللي هو الأبقار أو اللي هو العجول أو الخنزير
+
+139
+00:12:18,490 --> 00:12:24,570
+لمعالجة أو للحصول على insulin لمعالجة المرضى لكن
+
+140
+00:12:24,570 --> 00:12:29,120
+الآن طبعا بيتم اللي هو إنتاجالانسولين اللي هو من
+
+141
+00:12:29,120 --> 00:12:34,600
+خلال ال .. اللي هو ال .. ال recomponent اللي هو
+
+142
+00:12:34,600 --> 00:12:38,880
+DNA techniques هيبقى عندنا اللي .. اللي موجود اللي
+
+143
+00:12:38,880 --> 00:12:46,540
+هو recomponent human insulin أول
+
+144
+00:12:46,540 --> 00:12:54,580
+منتج بيتم الحصول عليه أو أول protein بيتم الحصول
+
+145
+00:12:54,580 --> 00:13:00,770
+عليه هو ال pre pro insulinإبارة عن بروتين بتكون من
+
+146
+00:13:00,770 --> 00:13:05,250
+meat amino acid formed by ribosomes in the rough
+
+147
+00:13:05,250 --> 00:13:09,730
+endoplasmic reticulum of the pancreatic beta cells
+
+148
+00:13:09,730 --> 00:13:12,870
+pre
+
+149
+00:13:12,870 --> 00:13:16,570
+-proinsulin is not detectable in the circulation
+
+150
+00:13:16,570 --> 00:13:23,390
+لو بحثت عن ال pre-proinsulin مش هنلاقيه موجود
+
+151
+00:13:23,390 --> 00:13:30,080
+بالcirculation بظروف الطبيعية لأنهمباشرة وبشكل
+
+152
+00:13:30,080 --> 00:13:37,560
+سريع بيصيرله Eclivage وبيتحول إلى Proinsulin اللي
+
+153
+00:13:37,560 --> 00:13:43,560
+عبارة عن بروتين بتكون من ستة و تمانين amino acid
+
+154
+00:13:43,560 --> 00:13:47,740
+يعني أول بروتين بينتج من ال pre-proinsulin ميت
+
+155
+00:13:47,740 --> 00:13:56,690
+amino acidمباشرة في سلّه cleavage اللي هو بيتم قطع
+
+156
+00:13:56,690 --> 00:14:00,570
+أربعة عشر amino acid وبيعطيني بروانسولين اللي هو
+
+157
+00:14:00,570 --> 00:14:04,850
+عبارة عن ستة و تمانين amino acid بالروتين
+
+158
+00:14:08,440 --> 00:14:13,600
+هذا مقفل في مجزرات مخصصة في مجلس الجيولوجيا لـ
+
+159
+00:14:13,600 --> 00:14:17,980
+Beta-cells حيث يحدث تنقل البروتراتيكي لالإنسلين
+
+160
+00:14:17,980 --> 00:14:24,290
+ومشاركة بيبتايدطبعا أي شيء بده يتم .. بده يصلله
+
+161
+00:14:24,290 --> 00:14:32,510
+secretion من الخلايا يبقى المفروض أنه طبعا ببدأ ..
+
+162
+00:14:32,510 --> 00:14:36,450
+بداية بيصله translation من خلال ال .. ال rough
+
+163
+00:14:36,450 --> 00:14:43,230
+endoplasmic reticulum و هذا ال protein بيكون موجود
+
+164
+00:14:43,230 --> 00:14:46,950
+في داخل physical و ال physical ذاتي بتتجه ل ال
+
+165
+00:14:46,950 --> 00:14:52,320
+geology اللي هو complex وهناك اللي هو بيصير في عنا
+
+166
+00:14:52,320 --> 00:14:57,080
+modification لهذه البروتينات وبعدين بيصير release
+
+167
+00:14:57,080 --> 00:15:03,660
+لهذه ال proteins في داخل vesicles عشان بعد هيك
+
+168
+00:15:03,660 --> 00:15:08,540
+يصلها اللي هو execution إلى خارج الخلية
+
+169
+00:15:11,740 --> 00:15:16,060
+يبقى عشان نحصل على الـ Insulin لابد أن نصير عندنا
+
+170
+00:15:16,060 --> 00:15:24,260
+Eclavage لـ C-Peptide وهذا الـ Eclavage بيتم من
+
+171
+00:15:24,260 --> 00:15:30,900
+خلال enzymes اللي يتسمى Pro-Hormone Convertases I
+
+172
+00:15:30,900 --> 00:15:37,880
+and IIعبارة عن Endopeptidases يبقى بيقطعوا في اللي
+
+173
+00:15:37,880 --> 00:15:45,160
+هو داخل البروتين وبيعملوا قطع لـ C-peptide عشان
+
+174
+00:15:45,160 --> 00:15:53,160
+نحصل على الانسلين يبقى أن ال enzyme pro hormone
+
+175
+00:15:53,160 --> 00:16:00,420
+convertase I بيجي وبيرتبط على الـ C-terminal end
+
+176
+00:16:00,420 --> 00:16:12,040
+الاند اللي هو RGN 31 وRGN 32وبيعمل قطع بين
+
+177
+00:16:12,040 --> 00:16:20,380
+الـ amino acid رقم 32 و33 وبيعطينا
+
+178
+00:16:20,380 --> 00:16:28,680
+له split 32 33 Pro-insulin عندنا
+
+179
+00:16:28,680 --> 00:16:30,880
+الـ enzyme الأخر اللي هو الـ Pro-hormone
+
+180
+00:16:30,880 --> 00:16:35,510
+converterase-2بيعمل cleavage في مكان آخر Cleaves
+
+181
+00:16:35,510 --> 00:16:39,210
+Pro Insulin on the c-terminal side of the basic
+
+182
+00:16:39,210 --> 00:16:45,810
+residues Lysine 64 وArginine 65 to generate split
+
+183
+00:16:45,810 --> 00:16:52,230
+65 and 66 Pro Insulin يجب يقطع بين ال amino acid
+
+184
+00:16:52,230 --> 00:16:55,790
+65 و ال amino acid 66
+
+185
+00:16:59,890 --> 00:17:07,630
+بعد ما بتتم عملية القطع بيصير فيه removal لـ two
+
+186
+00:17:07,630 --> 00:17:15,330
+exposed amino acids removal of two newly exposed C
+
+187
+00:17:15,330 --> 00:17:21,410
+-terminal basic amino acids واللي بيعمل ال removal
+
+188
+00:17:21,410 --> 00:17:26,270
+لهذه ال amino acids انزايم يسمى Carboxypeptidase-H
+
+189
+00:17:28,560 --> 00:17:34,240
+وبعدما تتم عملية القطع وعملية الـ removal لـ الـ
+
+190
+00:17:34,240 --> 00:17:39,920
+two amino acids هذه بينتج عندنا الـ Insulin و الـ
+
+191
+00:17:39,920 --> 00:17:46,300
+C-peptide يبقى
+
+192
+00:17:46,300 --> 00:17:50,380
+زي ما هو واضح عندنا بال figure هان هان اللي هو الـ
+
+193
+00:17:50,380 --> 00:17:54,720
+Pro-insulin هان عندنا اللي هو الـ A-chain و الـ B
+
+194
+00:17:54,720 --> 00:17:56,500
+-chain و هان الـ C-peptide
+
+195
+00:18:02,900 --> 00:18:08,600
+و عشان نحصل على ال insulin لابد من قطع ال C
+
+196
+00:18:08,600 --> 00:18:14,720
+-peptide زى ما قولنا أنه في عندنا two enzymes في
+
+197
+00:18:14,720 --> 00:18:21,640
+عندنا ال P-C-I هذا بيقطع بين العمينا أسل 32 و 33
+
+198
+00:18:21,640 --> 00:18:28,160
+زى ما هو واضح هان تمام بيبقى بيصير عندنا قطع هان
+
+199
+00:18:29,070 --> 00:18:34,310
+وعنا الانزيم الأخر اللي هو ال PC2 بيقطع بين اللي
+
+200
+00:18:34,310 --> 00:18:45,850
+هو خمسة وستين وستة وستين تمام
+
+201
+00:18:45,850 --> 00:18:52,950
+يبقى PC1 بيقطع بين 32 و33 وبنحصل
+
+202
+00:18:52,950 --> 00:18:57,780
+على اللي هو split 32 و33 Proinsulinبعد هيك عندنا
+
+203
+00:18:57,780 --> 00:19:02,900
+ال enzyme ال CBH زمولنا بيعمل removal ل ال two
+
+204
+00:19:02,900 --> 00:19:10,620
+amino acids و بنحصل على this 3130-t-pro-insulin و
+
+205
+00:19:10,620 --> 00:19:18,560
+عندنا بعد هيك ال enzyme الاخر اللي بيعمل قطع ل ال
+
+206
+00:19:18,560 --> 00:19:22,560
+.. اللي هو ال .. ال c-peptide من الناحية الأخرى
+
+207
+00:19:22,560 --> 00:19:28,570
+اللي بيقطع بين اربعة و ستة .. بينبين 64 و 65 و
+
+208
+00:19:28,570 --> 00:19:32,030
+بعدين بيصير برضه عندنا عن طريق ال و CpH بيصير
+
+209
+00:19:32,030 --> 00:19:39,800
+removal ل اللي هو ال two amino acidsفي عندنا two
+
+210
+00:19:39,800 --> 00:19:44,220
+pathways لهذه العملية عندنا الـ major pathway اللي
+
+211
+00:19:44,220 --> 00:19:52,180
+بتتم اللي هو بداية اللي قطع الـ PC1 بين الـ amino
+
+212
+00:19:52,180 --> 00:19:57,700
+acids 32 و33 أو 30 و بتتكمل العملية وفي عندنا ال
+
+213
+00:19:57,700 --> 00:20:05,140
+minor pathway اللي هو بيبدأ القطع بالـ PC2 و بيصير
+
+214
+00:20:05,140 --> 00:20:09,470
+بعد ذلك removal للـ twoأمينو أسيد و بعدين بيصير
+
+215
+00:20:09,470 --> 00:20:14,410
+عندنا قطع مرة أخرى ب ال PC-1 و removal ال two
+
+216
+00:20:14,410 --> 00:20:20,410
+amino acids عن طريق ال واسي pH و بنحصل بالنهاية
+
+217
+00:20:20,410 --> 00:20:29,050
+على انسولين و على ال C-peptide من
+
+218
+00:20:29,050 --> 00:20:37,080
+خلال الأبحاثلجوا انه لو صار في incubation لـ
+
+219
+00:20:37,080 --> 00:20:43,960
+Proinsulin مع ال BC-1 فقط لجوا انه ال BC-1 فعليا
+
+220
+00:20:43,960 --> 00:20:49,620
+بيعمل القطعين المطلوبين تمام بيعمل القطع اللي هو
+
+221
+00:20:49,620 --> 00:20:58,290
+بين32 و بين 33 و بين الـ 65 و بين اللي هو الـ 66
+
+222
+00:20:58,290 --> 00:21:03,790
+يبقى الـ BC1 قادر على أنه يقطع في هدول المنطقتين
+
+223
+00:21:03,790 --> 00:21:15,490
+بينما الـ BC2 لجوا أنه بيقطع فقط في هذه المنطقة زي
+
+224
+00:21:15,490 --> 00:21:18,450
+ما ذكرنا في الـ slider السابقة أنه في عندنا اللي
+
+225
+00:21:18,450 --> 00:21:19,590
+هو الـ minor pathway
+
+226
+00:21:22,170 --> 00:21:26,510
+وإنه less than 10% of pro-insulin is metabolized
+
+227
+00:21:26,510 --> 00:21:32,590
+via this 6465 pro-insulin which is present in
+
+228
+00:21:32,590 --> 00:21:37,250
+negligible amounts in humans المهم يا دي اللي هو
+
+229
+00:21:37,250 --> 00:21:41,930
+ال minor part و بينما إن this 3132 pro-insulin is
+
+230
+00:21:41,930 --> 00:21:46,510
+the major pro-insulin conversion intermediate
+
+231
+00:21:48,760 --> 00:21:53,560
+الجلوكوز هو اللي بيتحكم بيه الـ Synthesis لـ الـ
+
+232
+00:21:53,560 --> 00:21:58,460
+Proinsulin و أيضًا للإنزايم اللي هو الـ PC-1 اللي
+
+233
+00:21:58,460 --> 00:22:04,180
+بيعمل القطع و تحويه اللي بيحول الـ Proinsulin إلى
+
+234
+00:22:04,180 --> 00:22:08,540
+Insulinيبقى الـ Glucose regulates biosynthesis of
+
+235
+00:22:08,540 --> 00:22:14,000
+both Proinsulin and BC-1 لكن مالهوش أي تأثير على
+
+236
+00:22:14,000 --> 00:22:21,520
+الـ BC-2 أو على الـ Carboxypeptidase H يبقى بعد ما
+
+237
+00:22:21,520 --> 00:22:24,460
+اللي هو اتم انه عملية القطع بعد ذلك بيصير فيه انه
+
+238
+00:22:24,460 --> 00:22:29,800
+Exocytosis و بيصير فيه Release للإنسلين و للـ C
+
+239
+00:22:29,800 --> 00:22:30,640
+-Peptide
+
+240
+00:22:33,200 --> 00:22:40,440
+وبيدخلوا للكبد عن طريق ال portal circulation يبقى
+
+241
+00:22:40,440 --> 00:22:44,980
+بيصير فيه inner release وبيدخلوا للو الدم وبيدخلوا
+
+242
+00:22:44,980 --> 00:22:49,300
+للكبد عن طريق ال portal circulation و بعدين طبعا
+
+243
+00:22:49,300 --> 00:22:54,760
+بيصلوا إلى جميع أجزاء الجسم
+
+244
+00:22:56,750 --> 00:23:01,410
+بالإضافة للإنسولين والـ C-peptide برضه بنلاقي
+
+245
+00:23:01,410 --> 00:23:06,110
+small amounts of pro-insulin ومن ال intermediate
+
+246
+00:23:06,110 --> 00:23:12,970
+cleavage forms هدول بنلاقيهم برضه موجودين في ال
+
+247
+00:23:12,970 --> 00:23:17,250
+circulation طيب،
+
+248
+00:23:17,250 --> 00:23:21,470
+إيش ال stimulus أو ال signal اللي بتؤدي إلى ال
+
+249
+00:23:21,470 --> 00:23:26,700
+release of insulin؟الجلوكوز is the most important
+
+250
+00:23:26,700 --> 00:23:32,800
+physiological secretagogue for
+
+251
+00:23:32,800 --> 00:23:37,700
+insulin يبقى هو ال substance that promotes
+
+252
+00:23:37,700 --> 00:23:41,060
+secretion of insulin الجلوكوز substance that
+
+253
+00:23:41,060 --> 00:23:45,600
+promotes the secretion of insulin يبقى الزيادة
+
+254
+00:23:45,600 --> 00:23:52,140
+لبلد في البلد الجلوكوز بيعمل stimulationللـ beta
+
+255
+00:23:52,140 --> 00:23:57,680
+cells عشان تعمل اللي هو secretion للإنسلين وهذا
+
+256
+00:23:57,680 --> 00:24:01,140
+بيصير within minutes insulin release is
+
+257
+00:24:01,140 --> 00:24:06,420
+potentiated by substances such as the encretin
+
+258
+00:24:06,420 --> 00:24:13,680
+hormones يعني ان في شغلات برضه هذه بتزيد من إفراز
+
+259
+00:24:14,120 --> 00:24:17,560
+الانسولين زي عندنا الانكريتين hormones عبارة عن
+
+260
+00:24:17,560 --> 00:24:23,980
+مجموعة من الهرمونات اللي بيصلها release بعد الأكل
+
+261
+00:24:23,980 --> 00:24:29,200
+بجهة الهرمونات لما الإنسان بيتناول اللي هو الطعام
+
+262
+00:24:29,200 --> 00:24:34,220
+بيصير فيه عندنا release ل الانكريتين hormones زي
+
+263
+00:24:34,220 --> 00:24:37,440
+اللي هو ال glucagon-like peptide و ال glucose
+
+264
+00:24:37,440 --> 00:24:41,320
+-dependent insulinotropic polypeptide
+
+265
+00:24:42,100 --> 00:24:49,440
+و«كوليسايتوكاينين بيبتايد YY» و«إكزينتوموديولين»
+
+266
+00:24:49,440 --> 00:24:53,100
+كلها هذي هرمونات بس اللي ها release بعد تناول
+
+267
+00:24:53,100 --> 00:25:00,380
+الطعام وهذه الهرمونات كلها بتزيد من ال release
+
+268
+00:25:00,380 --> 00:25:02,300
+للإنسيلين
+
+269
+00:25:04,000 --> 00:25:07,940
+في المقابل إنه العديد من العوامل اللي بتعمل
+
+270
+00:25:07,940 --> 00:25:12,220
+Inhibition لـ Insulin Release ومنها الـ
+
+271
+00:25:12,220 --> 00:25:17,000
+Hypoglycemia يعني انخفاض في مستوى الـ Glucose إنه
+
+272
+00:25:17,000 --> 00:25:21,760
+الـ Somatostatin اللي بيفرز برضه في الـ Pancreas
+
+273
+00:25:21,760 --> 00:25:26,440
+من خلال الـ Delta Cells الموجودة في الـ Pancreas
+
+274
+00:25:26,710 --> 00:25:32,010
+هذا الـ hormone بيعمل اللي هو inhibition على الـ
+
+275
+00:25:32,010 --> 00:25:36,030
+beta cells وبالتالي بيقلل أو بيعمل inhibition للـ
+
+276
+00:25:36,030 --> 00:25:42,650
+release للإنسولين بالإضافة للعديد من ال drugs اللي
+
+277
+00:25:42,650 --> 00:25:47,770
+ممكن بتعمل inhibition للـ release للإنسولين من
+
+278
+00:25:47,770 --> 00:25:52,030
+خلال تأثيرها على ال beta cells
+
+279
+00:25:58,690 --> 00:26:01,690
+in health individuals insulin is released in a
+
+280
+00:26:01,690 --> 00:26:05,610
+pulsatile fashion يبقى بيكون اللي هو عن طريق اللي
+
+281
+00:26:05,610 --> 00:26:11,050
+هو pulses أه يبقى عندنا كل فترة بيصير في release
+
+282
+00:26:11,050 --> 00:26:15,210
+لكمية من ال insulin يبقى في عندنا pulsatile
+
+283
+00:26:15,210 --> 00:26:20,620
+release، pulseswith glucose and insulin the main
+
+284
+00:26:20,620 --> 00:26:25,140
+signals in the feedback loop يبقى هم اللي .. و
+
+285
+00:26:25,140 --> 00:26:28,780
+اللي بتحكمه و اللي بيعملوا اللي هو feedback أو
+
+286
+00:26:28,780 --> 00:26:31,240
+negative feedback على ال .. ال release اللي
+
+287
+00:26:31,240 --> 00:26:35,500
+glucose و ال insulin ال glucose اللي sets the
+
+288
+00:26:35,500 --> 00:26:39,000
+release of insulin from the pancreas into phases
+
+289
+00:26:39,000 --> 00:26:46,220
+يبقى لما بيدخل ال glucose ل الدم بيصير فيه انا
+
+290
+00:26:46,220 --> 00:26:52,210
+release لال insulinبالهو مرحلتين أو على مرحلتين
+
+291
+00:26:52,210 --> 00:27:01,410
+المرحلة الأولى بتبدأ بعد دقيقة إلى دقيقتين من دخول
+
+292
+00:27:01,410 --> 00:27:09,310
+الـ glucose للدم و بتنتهي عند عشر دقائق المرحلة
+
+293
+00:27:09,310 --> 00:27:13,330
+الأولى بتبدأ يعني بشكل سريع بعد دقيقة أو دقيقتين
+
+294
+00:27:13,890 --> 00:27:18,590
+وبتنتهي عند عشر دقائق وبهذه المرحلة بيكون في عندنا
+
+295
+00:27:18,590 --> 00:27:23,190
+release لكمية كبيرة من الانسولين يبقى sharp spike
+
+296
+00:27:23,190 --> 00:27:29,130
+represent the rapid release of stored insulin يبقى
+
+297
+00:27:29,130 --> 00:27:34,290
+بيصير release لكمية كبيرة من الانسولين بعد هيك
+
+298
+00:27:34,290 --> 00:27:38,070
+بتدخل المرحلة التانية beginning at the point where
+
+299
+00:27:38,070 --> 00:27:44,010
+the first phase ended بتبدأ بعد العشر دقائقوبتستمر
+
+300
+00:27:44,010 --> 00:27:50,030
+لغاية ما يرجع مستوى الـ glucose في الدم إلى
+
+301
+00:27:50,030 --> 00:27:58,570
+المستوى الطبيعي وهذه ممكن تستمر يعني لمدة 60 إلى
+
+302
+00:27:58,570 --> 00:28:08,940
+120 دقيقة أو يعني تنتهي بعد 60 إلى 120 دقيقةهذا
+
+303
+00:28:08,940 --> 00:28:15,200
+الـ figure بيوضح استجابة أو
+
+304
+00:28:15,200 --> 00:28:20,060
+الـ concentration للـ الانسولين بناء على ال
+
+305
+00:28:20,060 --> 00:28:28,060
+injection لجلوكوز في الدم يبين هنا إنه كمية
+
+306
+00:28:28,060 --> 00:28:34,720
+الانسولين اللي صلها detection في الدم و هنا إنه ال
+
+307
+00:28:34,720 --> 00:28:42,190
+timeهنا إن هو شخص طبيعي وزي ما قلنا إنه بيصير فيه
+
+308
+00:28:42,190 --> 00:28:48,750
+إنه release للإنسولين على مرحلتين هان اللي هو كمية
+
+309
+00:28:48,750 --> 00:28:54,310
+الإنسولين قبل ما يتم حقن الشخص بعشرين جرام من ال
+
+310
+00:28:54,310 --> 00:28:59,630
+glucose هان عند سفر صار إن عملية الحقنزي ما أحنا
+
+311
+00:28:59,630 --> 00:29:03,990
+شايفين أنه بتبدأ عندنا ال phase one المرحلة الأولى
+
+312
+00:29:03,990 --> 00:29:07,930
+زي ما قلنا خلال دقيقة إلى دقيقتين بيصير في عندي ال
+
+313
+00:29:07,930 --> 00:29:14,730
+release ل اللي هو كمية كبيرة من ال incidentبعد هيك
+
+314
+00:29:14,730 --> 00:29:18,050
+بعد وهذه بتستمر ل تقريبا عشر دقائق بعد هيك بتبدأ
+
+315
+00:29:18,050 --> 00:29:22,850
+عندي ال concentration ل ال insulin قل بنبدأ بيه
+
+316
+00:29:22,850 --> 00:29:27,670
+المرحلة التانية كل ما نزل ال glucose concentration
+
+317
+00:29:27,670 --> 00:29:33,650
+كل ما قلت كمية ال insulin الموجودة لغاية ما ترجع
+
+318
+00:29:33,650 --> 00:29:39,070
+كمية اللي هو ال insulin ل ال basal levels عندما
+
+319
+00:29:39,070 --> 00:29:44,940
+ترجع اللي هو ال concentration ل glucoseإلى المستوى
+
+320
+00:29:44,940 --> 00:29:50,860
+الطبيعي ال figures التانية اللي هو انها figure B
+
+321
+00:29:50,860 --> 00:29:57,780
+هذا بيوضح كمية ال insulin عند شخص مصاب بال type 2
+
+322
+00:29:57,780 --> 00:30:01,640
+diabetes mellitus و الناس المصابين بال type 2
+
+323
+00:30:01,640 --> 00:30:07,040
+diabetes mellitus بيفقدوا phase one بيكونش موجود
+
+324
+00:30:07,040 --> 00:30:13,730
+عندهم phase one عشان هيكلما بيتناولوا الـ
+
+325
+00:30:13,730 --> 00:30:18,610
+carbohydrates وبيدخل الجلوكوز للدم بنلاقي أنه بيظل
+
+326
+00:30:18,610 --> 00:30:23,150
+الـ الـ الـ glucose concentration مرتفعة فترة
+
+327
+00:30:23,150 --> 00:30:28,430
+طويلة في الدم لأنه الـ phase one المرحلة الأولى
+
+328
+00:30:28,430 --> 00:30:34,470
+مهمة ليه اللي هو خفض مستوى السكر سريعا لأن زي ما
+
+329
+00:30:34,470 --> 00:30:38,070
+قلنا بيصير release لكمية كبيرة من الانسولين و اللي
+
+330
+00:30:38,070 --> 00:30:44,370
+هو بشكل سريع لكن الـ type twoالـ diabetic patients
+
+331
+00:30:44,370 --> 00:30:48,730
+الـ phase one مش موجودة عندهم يعني جهان عند سفر
+
+332
+00:30:48,730 --> 00:30:53,330
+صار فيه عندي اللي هو injection لعشرين جرام من
+
+333
+00:30:53,330 --> 00:30:57,210
+الجلوكوز زي ما أحنا شايفين أنه مافيش عندنا spike
+
+334
+00:30:57,210 --> 00:31:01,770
+زي ما صار في هان يبقى ال phase one مش موجودة لكن
+
+335
+00:31:01,770 --> 00:31:08,150
+ال phase two موجودة بيبدأ بيرتفع عندنا ال insulin
+
+336
+00:31:11,130 --> 00:31:18,650
+و زي ما حكينا إنه هذا بياخد يعني فترات طويلة
+
+337
+00:31:18,650 --> 00:31:27,430
+للوصول إلى ال normal concentration يعني
+
+338
+00:31:27,430 --> 00:31:30,270
+لأ طبعا بال type 2 diabetes مش هيصل ل ال normal
+
+339
+00:31:30,270 --> 00:31:34,670
+يعني عشان يخفض ال glucose لكن طبعا مش هيصل ل ال
+
+340
+00:31:34,670 --> 00:31:41,520
+normal هيظل لنا ال glucose مرتفعبينما بي ال
+
+341
+00:31:41,520 --> 00:31:45,920
+patients with type 1 طبعا إنا مشكلة أصلا إحنا في
+
+342
+00:31:45,920 --> 00:31:52,280
+ال release of insulin لأنه عندنا اللي هو صار في
+
+343
+00:31:52,280 --> 00:31:56,040
+destruction ل ال beta cells وبالتالي يعني ال
+
+344
+00:31:56,040 --> 00:31:59,720
+insulin مش موجود أو موجود يعني ب very low
+
+345
+00:31:59,720 --> 00:32:00,860
+concentrations
+
+346
+00:32:03,380 --> 00:32:06,720
+يبقى زي ما شوفنا في ال figure الصابق with
+
+347
+00:32:06,720 --> 00:32:09,360
+progressive failure of beta cell function first
+
+348
+00:32:09,360 --> 00:32:15,740
+phase insulin response للجلوكوز is lost لكن أن ال
+
+349
+00:32:15,740 --> 00:32:21,060
+second phase بتظل اللي موجودة is preserved both
+
+350
+00:32:21,060 --> 00:32:23,520
+the first phase response and normal pulsatile
+
+351
+00:32:23,520 --> 00:32:26,760
+insulin secretion are lost يبقى ال first phase
+
+352
+00:32:26,760 --> 00:32:32,790
+بيفقد ال pulsatile insulin secretion بيفقدلكن الـ
+
+353
+00:32:32,790 --> 00:32:39,550
+second phase بتظل موجودة وطبعا ال word type one
+
+354
+00:32:39,550 --> 00:32:44,510
+أنه أصلا مشكلة في ال release للإنسلين وبالتالي
+
+355
+00:32:44,510 --> 00:32:50,110
+minimal or no insulin response النقطة التالية ال
+
+356
+00:32:50,110 --> 00:32:51,750
+insulin degradation
+
+357
+00:32:56,300 --> 00:32:58,660
+على الطريق الأول من خلال الـ Portal Circulation
+
+358
+00:32:58,660 --> 00:33:04,300
+نحن زي ما قلنا أنه بيصير فيه إطلاق للإنسلين بيدخل
+
+359
+00:33:04,300 --> 00:33:09,160
+للكبد عن طريق الـ Portal Circulation يبقى عندنا
+
+360
+00:33:09,160 --> 00:33:12,040
+الطريق الأول من خلال الـ Portal Circulation
+
+361
+00:33:12,040 --> 00:33:20,050
+تقريبًا 50% من الإنسلين يتم إخراجه من الجلديعني
+
+362
+00:33:20,050 --> 00:33:25,530
+where it is degraded يعني مش ممكن ال .. يعني مش كل
+
+363
+00:33:25,530 --> 00:33:29,030
+الكمية ممكن تستخدم ال degradation يعني ممكن يصير
+
+364
+00:33:29,030 --> 00:33:32,950
+فيه فعليًا extraction لخمسين بالمية من الانسولين
+
+365
+00:33:32,950 --> 00:33:41,390
+لكن ممكن يصير لاحقًا release لبعض من هذه الكمية
+
+366
+00:33:41,390 --> 00:33:46,630
+مرة أخرى لل circulation هو يعني مش كتير دقيقة أنه
+
+367
+00:33:46,990 --> 00:33:51,570
+الخمسين بالمية هذه بيصير لـ degradation يبقى بيصير
+
+368
+00:33:51,570 --> 00:33:55,410
+فيه extraction لخمسين بالمية من الانسلين لكن ممكن
+
+369
+00:33:55,410 --> 00:33:59,930
+لاحقا بعض من هذه الكمية اللي صارت ال extraction
+
+370
+00:33:59,930 --> 00:34:04,190
+ممكن ترجع تدخل ل ال circulation مرة أخرى
+
+371
+00:34:04,190 --> 00:34:07,370
+additional insulin degradation occurs in the
+
+372
+00:34:07,370 --> 00:34:12,300
+kidneysوعملية الـ degradation ها بتصير فيه الـ
+
+373
+00:34:12,300 --> 00:34:17,280
+tubules وبيه الـ proximal tubules بشكل خاص يبقى
+
+374
+00:34:17,280 --> 00:34:21,580
+بيصير فيه عندنا filtration للإنسلين عن طريق الـ
+
+375
+00:34:21,580 --> 00:34:27,760
+glomeruli بعد هيك بيصير فيه reabsorption للإنسلين
+
+376
+00:34:27,760 --> 00:34:31,520
+بيه ال proximal convoluted tubule وبتصير
+
+377
+00:34:31,520 --> 00:34:37,000
+degradation للإنسلين في داخل خلايا ال proximal
+
+378
+00:34:37,000 --> 00:34:38,620
+convoluted tubule
+
+379
+00:35:01,390 --> 00:35:07,330
+بنسبة لها الـ Pro Insulin بشكل طبيعي انها عدد صغير
+
+380
+00:35:09,190 --> 00:35:13,870
+of proinsulin enter the circulation لتقريبا تلاتة
+
+381
+00:35:13,870 --> 00:35:18,310
+بالمية of the amount of insulin بتلاتة بالمية من
+
+382
+00:35:18,310 --> 00:35:21,230
+كمية ال insulin اللي بتدخل اللي هو عندنا بتكون
+
+383
+00:35:21,230 --> 00:35:25,830
+عبارة عن ال proinsulin لكن بالنسبة لل proinsulin
+
+384
+00:35:25,830 --> 00:35:29,310
+ال hepatic clearance rate for proinsulin is only
+
+385
+00:35:29,310 --> 00:35:34,630
+25% of that for insulin يعني عندنا ال clearance
+
+386
+00:35:34,630 --> 00:35:41,940
+أقل مقارنة بالإنسلينوبالمقابل أيضًا الـ half-life
+
+387
+00:35:41,940 --> 00:35:47,260
+لـ الـ Proinsulin تقريبًا تلاتين دقيقة يبقى ال
+
+388
+00:35:47,260 --> 00:35:50,320
+clearance اللي بقت ال clearance أقل مقارنة
+
+389
+00:35:50,320 --> 00:35:54,400
+بالإنسلين ال half-life لالـ Proinsulin أعلى
+
+390
+00:35:54,400 --> 00:36:01,320
+تقريبًا بست مرات من الانسلين وبالتاليخلال اللي هو
+
+391
+00:36:01,320 --> 00:36:04,420
+الـ fasting state ممكن نلاقي إن الـ circulating
+
+392
+00:36:04,420 --> 00:36:10,100
+pro-insulin concentration approximately 10% to 15%
+
+393
+00:36:10,100 --> 00:36:15,800
+of insulin concentration اللي هو بسبب .. زي ما
+
+394
+00:36:15,800 --> 00:36:21,500
+ذكرنا السببين إنه الـ clearance أقل في الكبد و الـ
+
+395
+00:36:21,500 --> 00:36:28,120
+half-life أطول بالنسبة
+
+396
+00:36:28,120 --> 00:36:29,680
+للـ C-peptide
+
+397
+00:36:32,210 --> 00:36:34,850
+was initially thought to be devoid of biological
+
+398
+00:36:34,850 --> 00:36:38,950
+activity وكانوا بال .. بالأول بيفكروا أنه مافيش أي
+
+399
+00:36:38,950 --> 00:36:45,950
+وظيفة مهمة لـ C-peptide and
+
+400
+00:36:45,950 --> 00:36:48,510
+was necessary only to ensure the correct structure
+
+401
+00:36:48,510 --> 00:36:57,150
+of insulin لكن من خلال أبحاث اللي تمتعلى الـ C
+
+402
+00:36:57,150 --> 00:36:59,770
+-peptide لجوا إن الـ C-peptide維س بيولوجيكال
+
+403
+00:36:59,770 --> 00:37:02,550
+activity but its possible physiological
+
+404
+00:37:02,550 --> 00:37:07,010
+significance remains controversally يعني مافيش لسه
+
+405
+00:37:07,010 --> 00:37:11,490
+اتفاق على إيش فعليًا الوظيفة اللي بيقوم فيها الـ C
+
+406
+00:37:11,490 --> 00:37:16,150
+-peptide لكن عديد من الأبحاث بينت إنه في functions
+
+407
+00:37:16,150 --> 00:37:20,470
+مختلفة لـ C-peptide منها اللي هو عملوا كـ
+
+408
+00:37:20,470 --> 00:37:21,930
+antioxidant
+
+409
+00:37:23,940 --> 00:37:29,620
+ويمكن هذا شوية يعني منطقي لأنه طبعا إذا كان
+
+410
+00:37:29,620 --> 00:37:36,320
+ارتفاعنا لجلوكوز بالدم زي ما احنا عارفين ومن
+
+411
+00:37:36,320 --> 00:37:39,360
+خلال اللي هو الـ glycolysis وإنتاج الطاقة، هيصير
+
+412
+00:37:39,360 --> 00:37:43,100
+في عندنا release لـReactive Oxygen Species
+
+413
+00:37:43,100 --> 00:37:46,140
+وبالتالي
+
+414
+00:37:46,140 --> 00:37:51,520
+يعني وجود الـC-Beptide كـAntioxidant ممكناللي هو
+
+415
+00:37:51,520 --> 00:37:58,620
+يقلل من الـ Reactive Oxygen Species اللي هتتكون
+
+416
+00:37:58,620 --> 00:38:03,440
+الانسولين
+
+417
+00:38:03,440 --> 00:38:06,300
+و الـ C-peptide secreted into the portal
+
+418
+00:38:06,300 --> 00:38:09,960
+circulation in equimolar amounts يبقى نفس الكمية
+
+419
+00:38:09,960 --> 00:38:13,540
+لأن زي ما شفنا أنه أنا الـ Proinsulin بيصير في
+
+420
+00:38:13,540 --> 00:38:19,640
+عندي a cleavage يبقى كل انسولين moleculeمقابله في
+
+421
+00:38:19,640 --> 00:38:25,000
+عندنا C-peptide يبقى في عندي نفس الكميات من
+
+422
+00:38:25,000 --> 00:38:28,520
+الانسولين اللي بيستخدعها الليز بالمقابل بيصير نفس
+
+423
+00:38:28,520 --> 00:38:34,600
+الكمية من ال C-peptide fasting C-peptide
+
+424
+00:38:34,600 --> 00:38:37,760
+concentration are five to ten fold higher than
+
+425
+00:38:37,760 --> 00:38:43,130
+those of insulinيبقى نفس الكمية بتدخل الدم لكن لما
+
+426
+00:38:43,130 --> 00:38:46,630
+نيجي نقيس كمية الـ C-peptide عند شخصين بنلاقي أنه
+
+427
+00:38:46,630 --> 00:38:52,710
+خمس إلى عشر أضعاف كمية الـ Insulin الموجودة والسبب
+
+428
+00:38:52,710 --> 00:38:57,630
+بيعود إلى الـ longer half-life لـ C-peptide اللي
+
+429
+00:38:57,630 --> 00:39:02,910
+تقريبا خمسة و تلاتين دقيقة مقارة بالـ half-life
+
+430
+00:39:02,910 --> 00:39:10,150
+للإنسلين اللي قلنا عبارة عن تقريبا خمس دقائقأيضًا
+
+431
+00:39:10,150 --> 00:39:15,090
+the liver does not extract C-peptide بيبصيرش كمان
+
+432
+00:39:15,090 --> 00:39:19,370
+extraction لأ لـ C-peptide مقارنة بإنسلين اللي
+
+433
+00:39:19,370 --> 00:39:23,010
+قلنا تقريبًا خمسين بالمية من الانسلين اللي بدخل ال
+
+434
+00:39:23,010 --> 00:39:28,490
+portal circulation بيصله extractionالـ C-peptide
+
+435
+00:39:28,490 --> 00:39:32,830
+بيصيرها الـ removal من ال circulation برضه عن طريق
+
+436
+00:39:32,830 --> 00:39:38,450
+الكدنى و بيصير فيه degradation في الكدنى و كمية
+
+437
+00:39:38,450 --> 00:39:46,070
+قليلة من ال intact C-peptide بتطلع في ال urine
+
+438
+00:39:46,070 --> 00:39:49,670
+يعني زي ما هي بدون اي degradation
+
diff --git a/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/_h2KNL9Vj6A_raw.json b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/_h2KNL9Vj6A_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..fab6c0d60f7a3fe246b33db5e7a7d6c53365ba8e
--- /dev/null
+++ b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/_h2KNL9Vj6A_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 3029, "start": 2.87, "end": 30.29, "text": "Categories of increased risk for diabetes بيقنّا الفئات اللي احتمالية الإصابة بيه الـ diabetes عندهم أعلى أول شيء بيقنّا impaired glucose tolerance people who have blood glucose concentrations above normal but less than those required for diagnosis of diabetes malitus", "tokens": [34, 2968, 2083, 295, 6505, 3148, 337, 13881, 4724, 1829, 4587, 1863, 11703, 995, 27188, 19986, 9307, 13672, 1829, 1975, 33753, 2304, 6027, 10632, 33688, 9381, 16758, 3660, 4724, 1829, 3224, 2423, 39184, 13881, 43242, 16095, 5551, 3615, 23942, 5551, 12610, 44049, 38207, 4724, 1829, 4587, 1863, 11703, 995, 36762, 23997, 23368, 561, 567, 362, 3390, 23997, 33512, 3673, 2710, 457, 1570, 813, 729, 4739, 337, 15217, 295, 13881, 2806, 30973], "avg_logprob": -0.2832031212747097, "compression_ratio": 1.4361233480176212, "no_speech_prob": 0.0, "words": [{"start": 2.87, "end": 3.51, "word": "Categories", "probability": 0.6927083333333334}, {"start": 3.51, "end": 3.77, "word": " of", "probability": 0.958984375}, {"start": 3.77, "end": 4.29, "word": " increased", "probability": 0.72216796875}, {"start": 4.29, "end": 4.71, "word": " risk", "probability": 0.92431640625}, {"start": 4.71, "end": 5.09, "word": " for", "probability": 0.90478515625}, {"start": 5.09, "end": 5.85, "word": " diabetes", "probability": 0.80029296875}, {"start": 5.85, "end": 7.21, "word": " بيقنّا", "probability": 0.4950764973958333}, {"start": 7.21, "end": 7.93, "word": " الفئات", "probability": 0.9508463541666666}, {"start": 7.93, "end": 9.27, "word": " اللي", "probability": 0.90380859375}, {"start": 9.27, "end": 10.09, "word": " احتمالية", "probability": 0.976953125}, {"start": 10.09, "end": 10.79, "word": " الإصابة", "probability": 0.9683837890625}, {"start": 10.79, "end": 11.57, "word": " بيه", "probability": 0.658203125}, {"start": 11.57, "end": 11.95, "word": " الـ", "probability": 0.6575927734375}, {"start": 11.95, "end": 12.41, "word": " diabetes", "probability": 0.6005859375}, {"start": 12.41, "end": 14.03, "word": " عندهم", "probability": 0.98681640625}, {"start": 14.03, "end": 14.51, "word": " أعلى", "probability": 0.9241536458333334}, {"start": 14.51, "end": 16.83, "word": " أول", "probability": 0.882080078125}, {"start": 16.83, "end": 17.07, "word": " شيء", "probability": 0.5272216796875}, {"start": 17.07, "end": 17.31, "word": " بيقنّا", "probability": 0.78497314453125}, {"start": 17.31, "end": 17.79, "word": " impaired", "probability": 0.77490234375}, {"start": 17.79, "end": 18.71, "word": " glucose", "probability": 0.912109375}, {"start": 18.71, "end": 19.51, "word": " tolerance", "probability": 0.92138671875}, {"start": 19.51, "end": 20.87, "word": " people", "probability": 0.61474609375}, {"start": 20.87, "end": 21.15, "word": " who", "probability": 0.9326171875}, {"start": 21.15, "end": 21.53, "word": " have", "probability": 0.96826171875}, {"start": 21.53, "end": 21.85, "word": " blood", "probability": 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الـ impaired fasting glucose diagnosed by fasting glucose value between those of normal and diabetic individuals وها برضه نفس ال issue", "tokens": [12610, 39319, 4587, 995, 14111, 4724, 43042, 3224, 46811, 11933, 11242, 31845, 2655, 11296, 9154, 16490, 1211, 6027, 2423, 39184, 23256, 8978, 18863, 10943, 6055, 3794, 27884, 34683, 3794, 3615, 9957, 2423, 39184, 36762, 22371, 23997, 16899, 538, 22371, 23997, 2158, 1296, 729, 295, 2710, 293, 50238, 5346, 4032, 11296, 4724, 43042, 3224, 8717, 36178, 2423, 2734], "avg_logprob": -0.1978717739212102, "compression_ratio": 1.3689839572192513, "no_speech_prob": 0.0, "words": [{"start": 159.75, "end": 160.59, "word": "ولاحقاً", "probability": 0.796533203125}, {"start": 160.59, "end": 161.17, "word": " برضه", "probability": 0.9055989583333334}, {"start": 161.17, "end": 161.35, "word": " تم", "probability": 0.908203125}, {"start": 161.35, "end": 162.03, "word": " إضافتها", "probability": 0.98623046875}, {"start": 162.03, "end": 162.27, "word": " 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normal ولا هو diabetic برضه هذه المرحلة اللي هو بنسميها pre-diabetes بمرحلة الـ pre-diabetes ممكن انشخصها من خلال استخدام الـ Oral Glucose Tolerance Test وزي ما قلنا اللي هو بعد ساعتين بديكون عندنا ال concentration بين 140 ل 199", "tokens": [2407, 6027, 39184, 25276, 3714, 1829, 20292, 10874, 2288, 10943, 680, 11778, 1829, 3794, 20292, 2655, 2288, 46599, 6027, 2655, 6027, 1829, 20193, 31439, 2710, 49429, 31439, 50238, 4724, 43042, 3224, 29538, 9673, 2288, 5016, 37977, 13672, 1829, 31439, 44945, 38251, 1829, 11296, 659, 12, 4504, 12632, 4724, 29973, 5016, 37977, 2423, 39184, 659, 12, 4504, 12632, 3714, 43020, 16472, 8592, 9778, 9381, 11296, 9154, 16490, 1211, 6027, 44713, 9778, 3215, 10943, 2423, 39184, 1610, 304, 5209, 1311, 541, 21402, 260, 719, 9279, 4032, 11622, 1829, 19446, 12174, 1211, 8315, 13672, 1829, 31439, 39182, 8608, 995, 34268, 9957, 4724, 16254, 30544, 43242, 8315, 2423, 9856, 49374, 21548, 5296, 4303], "avg_logprob": -0.19545455276966095, "compression_ratio": 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insulin ومهمة العمل للإنسلين وبالتالي هذه المنطقة highly conserved among species يبقى يعني تم اللي هو المحافظة عليها ومتشابهة", "tokens": [6027, 20292, 31439, 661, 6172, 264, 1032, 4995, 5088, 14709, 4458, 295, 264, 363, 5021, 13672, 1829, 39896, 9673, 1863, 9566, 28671, 9154, 363, 9356, 5296, 363, 10880, 29538, 7038, 11462, 337, 264, 13910, 3069, 295, 21587, 4032, 2304, 16095, 3660, 18863, 42213, 24976, 28814, 1863, 3794, 1211, 9957, 46599, 6027, 2655, 6027, 1829, 29538, 9673, 1863, 9566, 28671, 5405, 1014, 6913, 3654, 6172, 7251, 3555, 4587, 7578, 37495, 22653, 46811, 13672, 1829, 31439, 9673, 5016, 31845, 19913, 3660, 25894, 11296, 4032, 2304, 2655, 8592, 16758, 3224, 3660], "avg_logprob": -0.1767907330159391, "compression_ratio": 1.5040983606557377, "no_speech_prob": 8.344650268554688e-07, "words": [{"start": 662.7, "end": 662.94, "word": "اللي", "probability": 0.645263671875}, {"start": 662.94, "end": 663.06, "word": " هو", "probability": 0.9150390625}, {"start": 663.06, "end": 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"-proinsulin", "probability": 0.9302978515625}, {"start": 802.41, "end": 802.59, "word": " مش", "probability": 0.90478515625}, {"start": 802.59, "end": 803.03, "word": " هنلاقيه", "probability": 0.90927734375}, {"start": 803.03, "end": 803.39, "word": " موجود", "probability": 0.9798177083333334}, {"start": 803.39, "end": 805.79, "word": " بالcirculation", "probability": 0.801513671875}, {"start": 805.79, "end": 806.49, "word": " بظروف", "probability": 0.78680419921875}, {"start": 806.49, "end": 807.21, "word": " الطبيعية", "probability": 0.962890625}, {"start": 807.21, "end": 807.81, "word": " لأنه", "probability": 0.9041341145833334}], "temperature": 1.0}, {"id": 31, "seek": 82846, "start": 808.14, "end": 828.46, "text": "مباشرة وبشكل سريع بيصيرله Eclivage وبيتحول إلى Proinsulin اللي عبارة عن بروتين بتكون من ستة و تمانين amino acid يعني أول بروتين بينتج من ال pre-proinsulin ميت amino acid", "tokens": [2304, 3555, 33599, 25720, 46599, 8592, 28820, 8608, 16572, 3615, 4724, 1829, 9381, 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{"start": 989.92, "end": 990.16, "word": " اللي", "probability": 0.781494140625}, {"start": 990.16, "end": 990.28, "word": " هو", "probability": 0.96875}, {"start": 990.28, "end": 990.32, "word": " الـ", "probability": 0.700439453125}, {"start": 990.32, "end": 990.46, "word": " Pro", "probability": 0.599609375}, {"start": 990.46, "end": 990.88, "word": "-hormone", "probability": 0.829345703125}, {"start": 990.88, "end": 991.56, "word": " converterase", "probability": 0.6861572265625}, {"start": 991.56, "end": 991.72, "word": "-2", "probability": 0.648681640625}], "temperature": 1.0}, {"id": 39, "seek": 101579, "start": 992.81, "end": 1015.79, "text": "بيعمل cleavage في مكان آخر Cleaves Pro Insulin on the c-terminal side of the basic residues Lysine 64 وArginine 65 to generate split 65 and 66 Pro Insulin يجب يقطع بين ال amino acid 65 و ال amino acid 66", "tokens": [21292, 25957, 1211, 1233, 706, 609, 8978, 3714, 41361, 19753, 34740, 8834, 5423, 1705, 9442, 17701, 322, 264, 269, 12, 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enzyme ال CBH زمولنا بيعمل removal ل ال two amino acids و بنحصل على this 3130-t-pro-insulin و عندنا بعد هيك ال enzyme الاخر اللي بيعمل قطع ل ال .. اللي هو ال .. ال c-peptide من الناحية الأخرى اللي بيقطع بين اربعة و ستة .. بين", "tokens": [3555, 22488, 39896, 4117, 43242, 8315, 2423, 24521, 2423, 18745, 39, 30767, 2304, 12610, 8315, 4724, 1829, 25957, 1211, 17933, 5296, 2423, 732, 24674, 21667, 4032, 44945, 5016, 36520, 15844, 341, 805, 42438, 12, 83, 12, 4318, 12, 1292, 17701, 4032, 43242, 8315, 39182, 39896, 4117, 2423, 24521, 2423, 47283, 2288, 13672, 1829, 4724, 1829, 25957, 1211, 12174, 9566, 3615, 5296, 2423, 4386, 13672, 1829, 31439, 2423, 4386, 2423, 269, 12, 494, 662, 482, 9154, 28239, 39319, 10632, 16247, 34740, 7578, 13672, 1829, 4724, 1829, 47432, 3615, 49374, 1975, 25513, 27884, 4032, 8608, 2655, 3660, 4386, 49374], "avg_logprob": -0.2691326469791179, "compression_ratio": 1.6805555555555556, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 1136.7, "end": 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1178.38, "end": 1207.08, "text": "في عندنا two pathways لهذه العملية عندنا الـ major pathway اللي بتتم اللي هو بداية اللي قطع الـ PC1 بين الـ amino acids 32 و33 أو 30 و بتتكمل العملية وفي عندنا ال minor pathway اللي هو بيبدأ القطع بالـ PC2 و بيصير بعد ذلك removal للـ two", "tokens": [41185, 43242, 8315, 732, 22988, 46740, 24192, 18863, 42213, 10632, 43242, 8315, 2423, 39184, 2563, 18590, 13672, 1829, 39894, 39237, 13672, 1829, 31439, 4724, 28259, 10632, 13672, 1829, 12174, 9566, 3615, 2423, 39184, 6465, 16, 49374, 2423, 39184, 24674, 21667, 8858, 4032, 10191, 34051, 2217, 4032, 39894, 2655, 24793, 1211, 18863, 42213, 10632, 4032, 41185, 43242, 8315, 2423, 6696, 18590, 13672, 1829, 31439, 4724, 1829, 44510, 10721, 25062, 9566, 3615, 20666, 39184, 6465, 17, 4032, 4724, 1829, 9381, 13546, 39182, 29910, 23275, 17933, 24976, 39184, 732], "avg_logprob": -0.25574713054744674, "compression_ratio": 1.7733990147783252, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1178.38, "end": 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دي", "probability": 0.786376953125}, {"start": 1296.99, "end": 1297.13, "word": " اللي", "probability": 0.98974609375}, {"start": 1297.13, "end": 1297.25, "word": " هو", "probability": 0.96044921875}, {"start": 1297.25, "end": 1297.33, "word": " ال", "probability": 0.830078125}, {"start": 1297.33, "end": 1297.61, "word": " minor", "probability": 0.87646484375}, {"start": 1297.61, "end": 1297.89, "word": " part", "probability": 0.82763671875}, {"start": 1297.89, "end": 1298.05, "word": " و", "probability": 0.44970703125}, {"start": 1298.05, "end": 1298.51, "word": " بينما", "probability": 0.728515625}, {"start": 1298.51, "end": 1298.77, "word": " إن", "probability": 0.474365234375}, {"start": 1298.77, "end": 1299.71, "word": " this", "probability": 0.334228515625}, {"start": 1299.71, "end": 1300.89, "word": " 3132", "probability": 0.9519856770833334}, {"start": 1300.89, "end": 1301.17, "word": " pro", "probability": 0.83349609375}, {"start": 1301.17, "end": 1301.67, "word": "-insulin", 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"text": "يبقى الـ Glucose regulates biosynthesis of both Proinsulin and BC-1 لكن مالهوش أي تأثير على الـ BC-2 أو على الـ Carboxypeptidase H يبقى بعد ما اللي هو اتم انه عملية القطع بعد ذلك بيصير فيه انه Exocytosis و بيصير فيه Release للإنسلين و للـ C-Peptide", "tokens": [1829, 3555, 4587, 7578, 2423, 39184, 5209, 1311, 541, 9837, 1024, 36997, 45601, 295, 1293, 1705, 1292, 17701, 293, 14359, 12, 16, 44381, 19446, 43761, 2407, 8592, 36632, 6055, 10721, 12984, 13546, 15844, 2423, 39184, 14359, 12, 17, 34051, 15844, 2423, 39184, 2741, 4995, 88, 494, 662, 327, 651, 389, 7251, 3555, 4587, 7578, 39182, 19446, 13672, 1829, 31439, 1975, 39237, 16472, 3224, 6225, 42213, 10632, 25062, 9566, 3615, 39182, 29910, 23275, 4724, 1829, 9381, 13546, 8978, 3224, 16472, 3224, 2111, 905, 4328, 8211, 4032, 4724, 1829, 9381, 13546, 8978, 3224, 34278, 24976, 28814, 1863, 3794, 1211, 9957, 4032, 24976, 39184, 383, 12, 47, 5250, 482], "avg_logprob": -0.30928738986220317, "compression_ratio": 1.5, 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و«إكزينتوموديولين» كلها هذي هرمونات بس اللي ها release بعد تناول الطعام وهذه الهرمونات كلها بتزيد من ال release للإنسيلين", "tokens": [2407, 36784, 4117, 12610, 1829, 3794, 995, 36081, 2407, 4117, 995, 9957, 9957, 4724, 1829, 3555, 2655, 995, 25708, 398, 56, 5933, 4032, 36784, 28814, 4117, 11622, 9957, 2655, 20498, 2407, 16254, 12610, 9957, 5933, 28242, 11296, 8032, 8848, 1829, 8032, 2288, 2304, 2407, 8315, 2655, 4724, 3794, 13672, 1829, 8032, 995, 4374, 39182, 6055, 8315, 12610, 41950, 3615, 10943, 37037, 24192, 2423, 3224, 2288, 2304, 2407, 8315, 2655, 28242, 11296, 39894, 11622, 25708, 9154, 2423, 4374, 24976, 28814, 1863, 3794, 26895, 9957], "avg_logprob": -0.24944195257765905, "compression_ratio": 1.6772151898734178, "no_speech_prob": 0.0, "words": [{"start": 1482.1, "end": 1483.6, "word": "و«كوليسايتوكاينين", "probability": 0.7407930814302884}, {"start": 1483.6, "end": 1484.4, "word": " بيبتايد", "probability": 0.8277587890625}, {"start": 1484.4, "end": 1486.1, "word": " YY»", 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"text": "إلى المستوى الطبيعي ال figures التانية اللي هو انها figure B هذا بيوضح كمية ال insulin عند شخص مصاب بال type 2 diabetes mellitus و الناس المصابين بال type 2 diabetes mellitus بيفقدوا phase one بيكونش موجود عندهم phase one عشان هيك", "tokens": [28814, 23942, 9673, 14851, 2407, 7578, 41950, 21292, 3615, 1829, 2423, 9624, 16712, 7649, 10632, 13672, 1829, 31439, 16472, 11296, 2573, 363, 23758, 4724, 1829, 2407, 11242, 5016, 9122, 2304, 10632, 2423, 21587, 43242, 13412, 9778, 9381, 3714, 9381, 16758, 20666, 2010, 568, 13881, 385, 285, 30973, 4032, 2423, 8315, 3794, 9673, 9381, 16758, 9957, 20666, 2010, 568, 13881, 385, 285, 30973, 4724, 33911, 28543, 14407, 5574, 472, 4724, 1829, 30544, 8592, 3714, 29245, 23328, 43242, 16095, 5574, 472, 6225, 8592, 7649, 39896, 4117], "avg_logprob": -0.1659007282818065, "compression_ratio": 1.6504854368932038, "no_speech_prob": 8.344650268554688e-07, "words": [{"start": 1783.72, "end": 1784.08, "word": "إلى", "probability": 0.7403564453125}, 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{"start": 2062.42, "end": 2063.52, "word": " بعد", "probability": 0.83154296875}, {"start": 2063.52, "end": 2063.76, "word": " هيك", "probability": 0.940673828125}, {"start": 2063.76, "end": 2064.12, "word": " بيصير", "probability": 0.9813232421875}, {"start": 2064.12, "end": 2064.68, "word": " فيه", "probability": 0.926513671875}, {"start": 2064.68, "end": 2066.1, "word": " reabsorption", "probability": 0.8936767578125}, {"start": 2066.1, "end": 2067.76, "word": " للإنسلين", "probability": 0.939453125}, {"start": 2067.76, "end": 2068.08, "word": " بيه", "probability": 0.9226888020833334}, {"start": 2068.08, "end": 2068.18, "word": " ال", "probability": 0.94140625}, {"start": 2068.18, "end": 2069.08, "word": " proximal", "probability": 0.786865234375}, {"start": 2069.08, "end": 2070.06, "word": " convoluted", "probability": 0.970703125}, {"start": 2070.06, "end": 2070.66, "word": " tubule", "probability": 0.84521484375}, {"start": 2070.66, "end": 2071.52, "word": " وبتصير", "probability": 0.807763671875}, {"start": 2071.52, "end": 2072.7, "word": " degradation", "probability": 0.9150390625}, {"start": 2072.7, "end": 2074.28, "word": " للإنسلين", "probability": 0.9740397135416666}, {"start": 2074.28, "end": 2074.52, "word": " في", "probability": 0.94921875}, {"start": 2074.52, "end": 2075.04, "word": " داخل", "probability": 0.9752604166666666}, {"start": 2075.04, "end": 2075.76, "word": " خلايا", "probability": 0.9293619791666666}, {"start": 2075.76, "end": 2076.28, "word": " ال", "probability": 0.97021484375}, {"start": 2076.28, "end": 2077.0, "word": " proximal", "probability": 0.89892578125}, {"start": 2077.0, "end": 2077.96, "word": " convoluted", "probability": 0.9749348958333334}, {"start": 2077.96, "end": 2078.62, "word": " tubule", "probability": 0.93994140625}], "temperature": 1.0}, {"id": 81, "seek": 210733, "start": 2101.39, "end": 2107.33, "text": "بنسبة لها الـ Pro Insulin بشكل طبيعي انها عدد صغير", "tokens": [3555, 1863, 35457, 3660, 5296, 11296, 2423, 39184, 1705, 9442, 17701, 4724, 8592, 28820, 23032, 21292, 3615, 1829, 16472, 11296, 6225, 3215, 3215, 20328, 17082, 13546], "avg_logprob": -0.5512152998535721, "compression_ratio": 0.9642857142857143, "no_speech_prob": 0.0, "words": [{"start": 2101.39, "end": 2101.93, "word": "بنسبة", "probability": 0.5700836181640625}, {"start": 2101.93, "end": 2102.09, "word": " لها", "probability": 0.37506103515625}, {"start": 2102.09, "end": 2102.23, "word": " الـ", "probability": 0.5294189453125}, {"start": 2102.23, "end": 2102.41, "word": " Pro", "probability": 0.68798828125}, {"start": 2102.41, "end": 2103.29, "word": " Insulin", "probability": 0.767578125}, {"start": 2103.29, "end": 2106.19, "word": " بشكل", "probability": 0.8932291666666666}, {"start": 2106.19, "end": 2106.53, "word": " طبيعي", "probability": 0.952880859375}, {"start": 2106.53, "end": 2107.01, "word": " انها", "probability": 0.425537109375}, {"start": 2107.01, "end": 2107.21, "word": " عدد", "probability": 0.4447835286458333}, {"start": 2107.21, "end": 2107.33, "word": " صغير", "probability": 0.788330078125}], "temperature": 1.0}, {"id": 82, "seek": 213881, "start": 2109.19, "end": 2138.81, "text": "of proinsulin enter the circulation لتقريبا تلاتة بالمية of the amount of insulin بتلاتة بالمية من كمية ال insulin اللي بتدخل اللي هو عندنا بتكون عبارة عن ال proinsulin لكن بالنسبة لل proinsulin ال hepatic clearance rate for proinsulin is only 25% of that for insulin يعني عندنا ال clearance أقل مقارنة بالإنسلين", "tokens": [2670, 447, 1292, 17701, 3242, 264, 23168, 5296, 2655, 4587, 16572, 3555, 995, 6055, 1211, 9307, 3660, 20666, 2304, 10632, 295, 264, 2372, 295, 21587, 39894, 1211, 9307, 3660, 20666, 2304, 10632, 9154, 9122, 2304, 10632, 2423, 21587, 13672, 1829, 39894, 3215, 9778, 1211, 13672, 1829, 31439, 43242, 8315, 39894, 30544, 6225, 3555, 9640, 3660, 18871, 2423, 447, 1292, 17701, 44381, 20666, 1863, 35457, 3660, 24976, 447, 1292, 17701, 2423, 26299, 2399, 27218, 3314, 337, 447, 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"probability": 0.867919921875}, {"start": 2119.19, "end": 2119.85, "word": " بتدخل", "probability": 0.9893798828125}, {"start": 2119.85, "end": 2120.57, "word": " اللي", "probability": 0.93701171875}, {"start": 2120.57, "end": 2120.67, "word": " هو", "probability": 0.60498046875}, {"start": 2120.67, "end": 2120.91, "word": " عندنا", "probability": 0.6246337890625}, {"start": 2120.91, "end": 2121.23, "word": " بتكون", "probability": 0.921875}, {"start": 2121.23, "end": 2121.53, "word": " عبارة", "probability": 0.94580078125}, {"start": 2121.53, "end": 2121.67, "word": " عن", "probability": 0.9599609375}, {"start": 2121.67, "end": 2121.75, "word": " ال", "probability": 0.8798828125}, {"start": 2121.75, "end": 2122.47, "word": " proinsulin", "probability": 0.763671875}, {"start": 2122.47, "end": 2124.19, "word": " لكن", "probability": 0.91552734375}, {"start": 2124.19, "end": 2124.65, "word": " بالنسبة", "probability": 0.844970703125}, {"start": 2124.65, "end": 2124.83, "word": " لل", "probability": 0.59423828125}, {"start": 2124.83, "end": 2125.83, "word": " proinsulin", "probability": 0.7413736979166666}, {"start": 2125.83, "end": 2126.51, "word": " ال", "probability": 0.9853515625}, {"start": 2126.51, "end": 2126.89, "word": " hepatic", "probability": 0.60040283203125}, {"start": 2126.89, "end": 2127.43, "word": " clearance", "probability": 0.89306640625}, {"start": 2127.43, "end": 2127.81, "word": " rate", "probability": 0.9765625}, {"start": 2127.81, "end": 2128.01, "word": " for", "probability": 0.86083984375}, {"start": 2128.01, "end": 2128.73, "word": " proinsulin", "probability": 0.86328125}, {"start": 2128.73, "end": 2128.99, "word": " is", "probability": 0.89306640625}, {"start": 2128.99, "end": 2129.31, "word": " only", "probability": 0.89990234375}, {"start": 2129.31, "end": 2130.03, "word": " 25", "probability": 0.61376953125}, {"start": 2130.03, "end": 2130.67, "word": "%", "probability": 0.7666015625}, {"start": 2130.67, "end": 2130.93, "word": " of", "probability": 0.94677734375}, {"start": 2130.93, "end": 2131.41, "word": " that", "probability": 0.9443359375}, {"start": 2131.41, "end": 2131.83, "word": " for", "probability": 0.92431640625}, {"start": 2131.83, "end": 2132.49, "word": " insulin", "probability": 0.97900390625}, {"start": 2132.49, "end": 2133.53, "word": " يعني", "probability": 0.829833984375}, {"start": 2133.53, "end": 2133.79, "word": " عندنا", "probability": 0.873046875}, {"start": 2133.79, "end": 2133.93, "word": " ال", "probability": 0.9873046875}, {"start": 2133.93, "end": 2134.63, "word": " clearance", "probability": 0.951171875}, {"start": 2134.63, "end": 2135.79, "word": " أقل", "probability": 0.955078125}, {"start": 2135.79, "end": 2137.33, "word": " مقارنة", "probability": 0.925}, {"start": 2137.33, "end": 2138.81, "word": " بالإنسلين", "probability": 0.862060546875}], "temperature": 1.0}, {"id": 83, "seek": 215958, "start": 2139.36, "end": 2159.58, "text": "وبالمقابل أيضًا الـ half-life لـ الـ Proinsulin تقريبًا تلاتين دقيقة يبقى ال clearance اللي بقت ال clearance أقل مقارنة بالإنسلين ال half-life لالـ Proinsulin أعلى تقريبًا بست مرات من الانسلين وبالتالي", "tokens": [37746, 45340, 4587, 16758, 1211, 36632, 11242, 14111, 995, 2423, 39184, 1922, 12, 9073, 5296, 39184, 2423, 39184, 1705, 1292, 17701, 6055, 4587, 16572, 3555, 14111, 995, 6055, 1211, 9307, 9957, 11778, 38436, 28671, 7251, 3555, 4587, 7578, 2423, 27218, 13672, 1829, 4724, 38149, 2423, 27218, 5551, 4587, 1211, 3714, 4587, 9640, 1863, 3660, 20666, 28814, 1863, 3794, 1211, 9957, 2423, 1922, 12, 9073, 5296, 6027, 39184, 1705, 1292, 17701, 5551, 3615, 23942, 6055, 4587, 16572, 3555, 14111, 995, 4724, 14851, 3714, 2288, 9307, 9154, 2423, 7649, 3794, 1211, 9957, 46599, 6027, 2655, 6027, 1829], "avg_logprob": -0.1668294247550269, "compression_ratio": 1.7458563535911602, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 2139.36, "end": 2140.36, "word": "وبالمقابل", "probability": 0.9525390625}, {"start": 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"probability": 0.6429036458333334}, {"start": 2152.64, "end": 2153.36, "word": " Proinsulin", "probability": 0.9495442708333334}, {"start": 2153.36, "end": 2154.4, "word": " أعلى", "probability": 0.9591471354166666}, {"start": 2154.4, "end": 2155.28, "word": " تقريبًا", "probability": 0.9971516927083334}, {"start": 2155.28, "end": 2155.62, "word": " بست", "probability": 0.880859375}, {"start": 2155.62, "end": 2156.34, "word": " مرات", "probability": 0.98486328125}, {"start": 2156.34, "end": 2156.82, "word": " من", "probability": 0.99658203125}, {"start": 2156.82, "end": 2158.12, "word": " الانسلين", "probability": 0.812451171875}, {"start": 2158.12, "end": 2159.58, "word": " وبالتالي", "probability": 0.91142578125}], "temperature": 1.0}, {"id": 84, "seek": 218967, "start": 2160.44, "end": 2189.68, "text": "خلال اللي هو الـ fasting state ممكن نلاقي إن الـ circulating pro-insulin concentration approximately 10% to 15% of insulin concentration اللي هو بسبب .. زي ما ذكرنا السببين إنه الـ clearance أقل في الكبد و الـ half-life أطول بالنسبة للـ C-peptide", "tokens": [9778, 1211, 6027, 13672, 1829, 31439, 2423, 39184, 22371, 1785, 3714, 43020, 8717, 15040, 38436, 36145, 2423, 39184, 39749, 447, 12, 1292, 17701, 9856, 10447, 1266, 4, 281, 2119, 4, 295, 21587, 9856, 13672, 1829, 31439, 4724, 35457, 3555, 4386, 30767, 1829, 19446, 29910, 37983, 8315, 21136, 3555, 3555, 9957, 36145, 3224, 2423, 39184, 27218, 5551, 4587, 1211, 8978, 33251, 44510, 4032, 2423, 39184, 1922, 12, 9073, 5551, 9566, 12610, 20666, 1863, 35457, 3660, 24976, 39184, 383, 12, 494, 662, 482], "avg_logprob": -0.22237043228091263, "compression_ratio": 1.5, "no_speech_prob": 0.0, "words": [{"start": 2160.44, "end": 2161.06, "word": "خلال", "probability": 0.9420572916666666}, {"start": 2161.06, "end": 2161.24, "word": " اللي", "probability": 0.5758056640625}, {"start": 2161.24, "end": 2161.32, "word": " هو", "probability": 0.9521484375}, {"start": 2161.32, "end": 2161.46, "word": " الـ", "probability": 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0.83203125}, {"start": 2181.7, "end": 2182.2, "word": "-life", "probability": 0.908203125}, {"start": 2182.2, "end": 2183.32, "word": " أطول", "probability": 0.98974609375}, {"start": 2183.32, "end": 2188.12, "word": " بالنسبة", "probability": 0.8985595703125}, {"start": 2188.12, "end": 2188.52, "word": " للـ", "probability": 0.700439453125}, {"start": 2188.52, "end": 2188.92, "word": " C", "probability": 0.8232421875}, {"start": 2188.92, "end": 2189.68, "word": "-peptide", "probability": 0.919921875}], "temperature": 1.0}, {"id": 85, "seek": 221523, "start": 2192.21, "end": 2215.23, "text": "was initially thought to be devoid of biological activity وكانوا بال .. بالأول بيفكروا أنه مافيش أي وظيفة مهمة لـ C-peptide and was necessary only to ensure the correct structure of insulin لكن من خلال أبحاث اللي تمت", "tokens": [6569, 9105, 1194, 281, 312, 1905, 17079, 295, 13910, 5191, 4032, 41361, 14407, 20666, 4386, 20666, 10721, 12610, 4724, 33911, 37983, 14407, 14739, 3224, 19446, 41185, 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"end": 2234.43, "word": " بينت", "probability": 0.6514892578125}, {"start": 2234.43, "end": 2234.83, "word": " إنه", "probability": 0.632568359375}, {"start": 2234.83, "end": 2235.01, "word": " في", "probability": 0.93017578125}, {"start": 2235.01, "end": 2236.15, "word": " functions", "probability": 0.72119140625}, {"start": 2236.15, "end": 2236.81, "word": " مختلفة", "probability": 0.9925537109375}, {"start": 2236.81, "end": 2236.99, "word": " لـ", "probability": 0.5716552734375}, {"start": 2236.99, "end": 2237.19, "word": " C", "probability": 0.732421875}, {"start": 2237.19, "end": 2237.81, "word": "-peptide", "probability": 0.97412109375}, {"start": 2237.81, "end": 2238.55, "word": " منها", "probability": 0.97314453125}, {"start": 2238.55, "end": 2238.97, "word": " اللي", "probability": 0.979248046875}, {"start": 2238.97, "end": 2239.23, "word": " هو", "probability": 0.623046875}, {"start": 2239.23, "end": 2239.91, "word": " عملوا", "probability": 0.9449869791666666}, {"start": 2239.91, "end": 2240.47, "word": " كـ", "probability": 0.6085205078125}, {"start": 2240.47, "end": 2241.93, "word": " antioxidant", "probability": 0.79931640625}], "temperature": 1.0}, {"id": 87, "seek": 227060, "start": 2243.94, "end": 2270.6, "text": "ويمكن هذا شوية يعني منطقي لأنه طبعا إذا كان ارتفاعنا لجلوكوز بالدم زي ما احنا عارفين ومن خلال اللي هو الـ glycolysis وإنتاج الطاقة، هيصير في عندنا release لـReactive Oxygen Species وبالتالي يعني وجود الـC-Beptide كـAntioxidant ممكن", "tokens": [2407, 32640, 19452, 23758, 13412, 2407, 10632, 37495, 22653, 9154, 9566, 38436, 5296, 33456, 3224, 23032, 3555, 3615, 995, 11933, 15730, 25961, 1975, 43500, 5172, 45761, 8315, 5296, 7435, 1211, 2407, 4117, 2407, 11622, 20666, 40448, 30767, 1829, 19446, 1975, 5016, 8315, 6225, 9640, 5172, 9957, 4032, 27842, 16490, 1211, 6027, 13672, 1829, 31439, 2423, 39184, 22633, 1291, 356, 17122, 4032, 28814, 29399, 26108, 41950, 995, 28671, 12399, 8032, 1829, 9381, 13546, 8978, 43242, 8315, 4374, 5296, 39184, 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"end": 2257.16, "word": " الـ", "probability": 0.790771484375}, {"start": 2257.16, "end": 2257.92, "word": " glycolysis", "probability": 0.8145751953125}, {"start": 2257.92, "end": 2258.56, "word": " وإنتاج", "probability": 0.917236328125}, {"start": 2258.56, "end": 2259.04, "word": " الطاقة،", "probability": 0.8148193359375}, {"start": 2259.04, "end": 2259.36, "word": " هيصير", "probability": 0.80169677734375}, {"start": 2259.36, "end": 2259.5, "word": " في", "probability": 0.95556640625}, {"start": 2259.5, "end": 2260.4, "word": " عندنا", "probability": 0.692138671875}, {"start": 2260.4, "end": 2261.28, "word": " release", "probability": 0.736328125}, {"start": 2261.28, "end": 2262.08, "word": " لـReactive", "probability": 0.718994140625}, {"start": 2262.08, "end": 2262.54, "word": " Oxygen", "probability": 0.9267578125}, {"start": 2262.54, "end": 2263.1, "word": " Species", "probability": 0.874267578125}, {"start": 2263.1, "end": 2266.14, "word": " وبالتالي", "probability": 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2274.18, "word": " Reactive", "probability": 0.6168212890625}, {"start": 2274.18, "end": 2274.72, "word": " Oxygen", "probability": 0.82470703125}, {"start": 2274.72, "end": 2275.44, "word": " Species", "probability": 0.78466796875}, {"start": 2275.44, "end": 2276.96, "word": " اللي", "probability": 0.927978515625}, {"start": 2276.96, "end": 2278.62, "word": " هتتكون", "probability": 0.9095458984375}, {"start": 2278.62, "end": 2283.44, "word": " الانسولين", "probability": 0.760498046875}, {"start": 2283.44, "end": 2284.04, "word": " و", "probability": 0.724609375}, {"start": 2284.04, "end": 2284.44, "word": " الـ", "probability": 0.58447265625}, {"start": 2284.44, "end": 2284.54, "word": " C", "probability": 0.271484375}, {"start": 2284.54, "end": 2284.96, "word": "-peptide", "probability": 0.7430419921875}, {"start": 2284.96, "end": 2285.56, "word": " secreted", "probability": 0.685302734375}, {"start": 2285.56, "end": 2285.78, "word": " into", "probability": 0.72705078125}, {"start": 2285.78, "end": 2286.0, "word": " the", "probability": 0.8369140625}, {"start": 2286.0, "end": 2286.3, "word": " portal", "probability": 0.953125}, {"start": 2286.3, "end": 2286.96, "word": " circulation", "probability": 0.92041015625}, {"start": 2286.96, "end": 2287.22, "word": " in", "probability": 0.92578125}, {"start": 2287.22, "end": 2287.88, "word": " equimolar", "probability": 0.9055989583333334}, {"start": 2287.88, "end": 2288.48, "word": " amounts", "probability": 0.9052734375}, {"start": 2288.48, "end": 2289.22, "word": " يبقى", "probability": 0.9547119140625}, {"start": 2289.22, "end": 2289.44, "word": " نفس", "probability": 0.997802734375}, {"start": 2289.44, "end": 2289.96, "word": " الكمية", "probability": 0.8819986979166666}, {"start": 2289.96, "end": 2290.48, "word": " لأن", "probability": 0.5164794921875}, {"start": 2290.48, "end": 2290.66, "word": " زي", "probability": 0.645263671875}, {"start": 2290.66, "end": 2290.82, "word": " ما", "probability": 0.9873046875}, {"start": 2290.82, "end": 2291.36, "word": " شفنا", "probability": 0.84326171875}, {"start": 2291.36, "end": 2291.56, "word": " أنه", "probability": 0.60888671875}, {"start": 2291.56, "end": 2291.72, "word": " أنا", "probability": 0.2415771484375}, {"start": 2291.72, "end": 2291.92, "word": " الـ", "probability": 0.90283203125}, {"start": 2291.92, "end": 2292.56, "word": " Proinsulin", "probability": 0.6698404947916666}, {"start": 2292.56, "end": 2293.42, "word": " بيصير", "probability": 0.8826904296875}, {"start": 2293.42, "end": 2293.54, "word": " في", "probability": 0.955078125}, {"start": 2293.54, "end": 2293.84, "word": " عندي", "probability": 0.6842041015625}, {"start": 2293.84, "end": 2293.96, "word": " a", "probability": 0.1278076171875}, {"start": 2293.96, "end": 2294.58, "word": " cleavage", "probability": 0.9733072916666666}, {"start": 2294.58, "end": 2295.26, "word": " يبقى", "probability": 0.965576171875}, {"start": 2295.26, "end": 2295.72, "word": " كل", "probability": 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{"start": 2362.39, "end": 2362.55, "word": " اللي", "probability": 0.98095703125}, {"start": 2362.55, "end": 2362.93, "word": " بدخل", "probability": 0.8484700520833334}, {"start": 2362.93, "end": 2363.01, "word": " ال", "probability": 0.8544921875}, {"start": 2363.01, "end": 2363.27, "word": " portal", "probability": 0.91015625}, {"start": 2363.27, "end": 2363.91, "word": " circulation", "probability": 0.98193359375}, {"start": 2363.91, "end": 2364.59, "word": " بيصله", "probability": 0.6575927734375}, {"start": 2364.59, "end": 2366.33, "word": " extraction", "probability": 0.87060546875}], "temperature": 1.0}, {"id": 92, "seek": 238967, "start": 2367.41, "end": 2389.67, "text": "الـ C-peptide بيصيرها الـ removal من ال circulation برضه عن طريق الكدنى و بيصير فيه degradation في الكدنى و كمية قليلة من ال intact C-peptide بتطلع في ال urine يعني زي ما هي بدون اي degradation", "tokens": [6027, 39184, 383, 12, 494, 662, 482, 4724, 1829, 9381, 13546, 11296, 2423, 39184, 17933, 9154, 2423, 23168, 4724, 43042, 3224, 18871, 23032, 16572, 4587, 33251, 3215, 1863, 7578, 4032, 4724, 1829, 9381, 13546, 8978, 3224, 40519, 8978, 33251, 3215, 1863, 7578, 4032, 9122, 2304, 10632, 12174, 20292, 37977, 9154, 2423, 23493, 383, 12, 494, 662, 482, 39894, 9566, 1211, 3615, 8978, 2423, 27638, 37495, 22653, 30767, 1829, 19446, 39896, 47525, 11536, 1975, 1829, 40519], "avg_logprob": -0.1573807608924414, "compression_ratio": 1.5932203389830508, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 2367.41, "end": 2367.79, "word": "الـ", "probability": 0.974853515625}, {"start": 2367.79, "end": 2367.91, "word": " C", "probability": 0.26123046875}, {"start": 2367.91, "end": 2368.49, "word": "-peptide", "probability": 0.8984375}, {"start": 2368.49, "end": 2370.17, "word": " بيصيرها", "probability": 0.7541015625}, {"start": 2370.17, "end": 2370.25, "word": " الـ", "probability": 0.595703125}, {"start": 2370.25, "end": 2370.61, "word": " removal", "probability": 0.9287109375}, {"start": 2370.61, "end": 2371.13, "word": " من", "probability": 0.9873046875}, {"start": 2371.13, "end": 2371.39, "word": " ال", "probability": 0.978515625}, {"start": 2371.39, "end": 2371.89, "word": " circulation", "probability": 0.439453125}, {"start": 2371.89, "end": 2372.27, "word": " برضه", "probability": 0.8448893229166666}, {"start": 2372.27, "end": 2372.45, "word": " عن", "probability": 0.9697265625}, {"start": 2372.45, "end": 2372.83, "word": " طريق", "probability": 0.99658203125}, {"start": 2372.83, "end": 2373.39, "word": " الكدنى", "probability": 0.79248046875}, {"start": 2373.39, "end": 2373.47, "word": " و", "probability": 0.521484375}, {"start": 2373.47, "end": 2373.79, "word": " بيصير", "probability": 0.9346923828125}, {"start": 2373.79, "end": 2374.05, "word": " فيه", "probability": 0.906982421875}, {"start": 2374.05, "end": 2374.69, "word": " degradation", "probability": 0.94873046875}, {"start": 2374.69, "end": 2376.21, "word": " في", "probability": 0.93017578125}, {"start": 2376.21, "end": 2377.51, "word": " الكدنى", "probability": 0.928466796875}, {"start": 2377.51, "end": 2377.87, "word": " و", "probability": 0.943359375}, {"start": 2377.87, "end": 2378.45, "word": " كمية", "probability": 0.9632161458333334}, {"start": 2378.45, "end": 2379.19, "word": " قليلة", "probability": 0.9733072916666666}, {"start": 2379.19, "end": 2380.11, "word": " من", "probability": 0.9951171875}, {"start": 2380.11, "end": 2380.99, "word": " ال", "probability": 0.98876953125}, {"start": 2380.99, "end": 2381.93, "word": " intact", "probability": 0.218505859375}, {"start": 2381.93, "end": 2382.67, "word": " C", "probability": 0.90380859375}, {"start": 2382.67, "end": 2383.31, "word": "-peptide", "probability": 0.9522705078125}, {"start": 2383.31, "end": 2384.91, "word": " بتطلع", "probability": 0.9801025390625}, {"start": 2384.91, "end": 2385.37, "word": " في", "probability": 0.9873046875}, {"start": 2385.37, "end": 2385.61, "word": " ال", "probability": 0.85205078125}, {"start": 2385.61, "end": 2386.07, "word": " urine", "probability": 0.87353515625}, {"start": 2386.07, "end": 2387.53, "word": " يعني", "probability": 0.83154296875}, {"start": 2387.53, "end": 2387.73, "word": " زي", "probability": 0.97119140625}, {"start": 2387.73, "end": 2387.81, "word": " ما", "probability": 0.982421875}, {"start": 2387.81, "end": 2388.01, "word": " هي", "probability": 0.9375}, {"start": 2388.01, "end": 2388.53, "word": " بدون", "probability": 0.992919921875}, {"start": 2388.53, "end": 2388.93, "word": " اي", "probability": 0.7127685546875}, {"start": 2388.93, "end": 2389.67, "word": " degradation", "probability": 0.96728515625}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2391.446375, "duration_after_vad": 2275.325624999992}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/_h2KNL9Vj6A_raw.srt b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/_h2KNL9Vj6A_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..04da9b140024c23f34a46717f4dccf5c3c865f95
--- /dev/null
+++ b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/_h2KNL9Vj6A_raw.srt
@@ -0,0 +1,1752 @@
+1
+00:00:02,870 --> 00:00:07,210
+Categories of increased risk for diabetes بيقنّا
+
+2
+00:00:07,210 --> 00:00:12,410
+الفئات اللي احتمالية الإصابة بيه الـ diabetes
+
+3
+00:00:12,410 --> 00:00:18,710
+عندهم أعلى أول شيء بيقنّا impaired glucose
+
+4
+00:00:18,710 --> 00:00:22,330
+tolerance people who have blood glucose
+
+5
+00:00:22,330 --> 00:00:26,490
+concentrations above normal but less than those
+
+6
+00:00:26,490 --> 00:00:33,290
+required for diagnosis of diabetes malitusوهذا
+
+7
+00:00:33,290 --> 00:00:43,410
+اللي .. اللي هو مرتبط بقياس للجلوكوز عن طريق اللي
+
+8
+00:00:43,410 --> 00:00:48,890
+هو الـ Oral Glucose Tolerance Test وعنا
+
+9
+00:00:48,890 --> 00:00:55,650
+القياس لجلوكوز بعد ساعتين من إعطاء اللي هو الجرعة
+
+10
+00:00:55,650 --> 00:01:01,580
+لجلوكوز بيكون بين مية وأربعين إلى مية تسعةو
+
+11
+00:01:01,580 --> 00:01:06,260
+التسعين طبعا بهذا الحالة يعني ما نقدرش نقول أن هذا
+
+12
+00:01:06,260 --> 00:01:11,420
+عنده diabetes mellitus لأن عشان نقول أنه عنده
+
+13
+00:01:11,420 --> 00:01:14,480
+diabetes mellitus المفروض يكون ال glucose
+
+14
+00:01:14,480 --> 00:01:22,260
+concentration أكتر من 200 و ال normal أقل من 140
+
+15
+00:01:22,260 --> 00:01:28,990
+لأ هو مع ال normal ولا هومع الأشخاص اللي مصابين
+
+16
+00:01:28,990 --> 00:01:34,650
+بالسكري، في 140 ل 199 هذا الشخص بيكون عنده ما يسمى
+
+17
+00:01:34,650 --> 00:01:41,270
+بالـ Impaired Glucose Tolerance أو اللي بنسميهم أو
+
+18
+00:01:41,270 --> 00:01:46,010
+بنسمي المرحلة هذه يعني Pre-diabetes اللي هي مرحلة
+
+19
+00:01:46,010 --> 00:01:48,490
+ما قبل السكري
+
+20
+00:01:53,340 --> 00:01:55,620
+لتخلص من جلوكوز صحيح صحيح الصحيح الصحيح الصحيح
+
+21
+00:01:55,620 --> 00:01:56,320
+الصحيح الصحيح الصحيح الصحيح الصحيح الصحيح الصحيح
+
+22
+00:01:56,320 --> 00:02:02,000
+الصحيح الصحيح الصحيح الصحيح الصحيح الصحيح الصحيح
+
+23
+00:02:02,000 --> 00:02:02,780
+الصحيح الصحيح الصحيح الصحيح الصحيح الصحيح الصحيح
+
+24
+00:02:02,780 --> 00:02:07,560
+الصحيح الصحيح الصحيح الصحيح الصحيح الصحيح الصحيح
+
+25
+00:02:07,560 --> 00:02:08,040
+الصحيح الصحيح الصحيح الصحيح الصحيح الصحيح الصحيح
+
+26
+00:02:08,040 --> 00:02:08,300
+الصحيح الصحيح الصحيح الصحيح الصحيح الصحيح الصحيح
+
+27
+00:02:08,300 --> 00:02:13,500
+الصحيح الصحيح الصحيح الصحيح الصحيح الصحيحبعد هيك
+
+28
+00:02:13,500 --> 00:02:16,160
+يعني عشان يتجنبوا استخدام الـ oral glucose
+
+29
+00:02:16,160 --> 00:02:21,260
+tolerance test صار في عندنا اللي هو اللي هي
+
+30
+00:02:21,260 --> 00:02:24,780
+category أو مصطلح آخر اللي يسمى impaired fasting
+
+31
+00:02:24,780 --> 00:02:29,540
+glucose و
+
+32
+00:02:29,540 --> 00:02:35,540
+هذه تم إضافتها طبعا عن طريق ال ADA ال American
+
+33
+00:02:35,540 --> 00:02:42,270
+Wadiabeta Associationولاحقاً برضه تم إضافتها من
+
+34
+00:02:42,270 --> 00:02:49,510
+خلال الـ WHO في العام تسعة وتسعين الـ
+
+35
+00:02:49,510 --> 00:02:52,310
+impaired fasting glucose diagnosed by fasting
+
+36
+00:02:52,310 --> 00:02:55,590
+glucose value between those of normal and diabetic
+
+37
+00:02:55,590 --> 00:03:01,330
+individuals وها برضه نفس ال issueالمفروض الشخص
+
+38
+00:03:01,330 --> 00:03:05,110
+طبيعي إذا كان ال glucose عنده طبعا احنا بنحكي على
+
+39
+00:03:05,110 --> 00:03:10,910
+glucose لشخص صايم ال glucose بدي يكون طبيعي إذا
+
+40
+00:03:10,910 --> 00:03:16,410
+كان أقل من مية و بدي يكون عنده diabetes إذا كان ال
+
+41
+00:03:16,410 --> 00:03:21,030
+concentration أكتر من 126 يبقى ال concentration
+
+42
+00:03:21,030 --> 00:03:27,800
+هان بين ميةوالـ 125 ميلي جرام per ديسليتر وبالتالي
+
+43
+00:03:27,800 --> 00:03:32,580
+لا هو normal ولا هو diabetic برضه هذه المرحلة اللي
+
+44
+00:03:32,580 --> 00:03:36,280
+هو بنسميها pre-diabetes بمرحلة الـ pre-diabetes
+
+45
+00:03:36,280 --> 00:03:41,420
+ممكن انشخصها من خلال استخدام الـ Oral Glucose
+
+46
+00:03:41,420 --> 00:03:45,840
+Tolerance Test وزي ما قلنا اللي هو بعد ساعتين
+
+47
+00:03:45,840 --> 00:03:52,030
+بديكون عندنا ال concentration بين 140 ل 199أو من
+
+48
+00:03:52,030 --> 00:03:58,590
+خلال فحص الجلوكوز لشخص صايم وبتكون الـ
+
+49
+00:03:58,590 --> 00:04:05,910
+concentration بين 100 إلى 125 طبعا
+
+50
+00:04:05,910 --> 00:04:08,930
+هذه ال .. ال concentration اللي هو 100 إلى 125
+
+51
+00:04:08,930 --> 00:04:14,770
+بناء على ال American Diabetes Association لكن
+
+52
+00:04:14,770 --> 00:04:22,450
+بالنسبة للـ WHO الأرقام مختلفةوالـ WHO بتعتبر أنه
+
+53
+00:04:22,450 --> 00:04:30,710
+ال cut-off value لال .. اللي هو ال normal 110 ومش
+
+54
+00:04:30,710 --> 00:04:36,810
+100 وبالتالي إذا كان أن الشخص ال concentration لال
+
+55
+00:04:36,810 --> 00:04:41,270
+glucose ال fasting اللي هو ال glucose من 110 ل125
+
+56
+00:04:42,940 --> 00:04:47,440
+بناء طبعا على اللي هو ال WHO يبقى بنقول أن هذا
+
+57
+00:04:47,440 --> 00:04:58,420
+الشخص عنده pre diabetes في
+
+58
+00:04:58,420 --> 00:05:04,880
+2009 تم إضافة اللي هو فحص آخر اللي
+
+59
+00:05:04,880 --> 00:05:09,280
+اللي هو برضه ال detection of pre diabetes status
+
+60
+00:05:09,280 --> 00:05:11,660
+اللي هو ال hemoglobin A1C
+
+61
+00:05:14,730 --> 00:05:19,910
+الناس مع قيمة Hemoglobin A1C تحت قطع 4 ديابتا الى
+
+62
+00:05:19,910 --> 00:05:24,890
+6.5 ولكن أعلى مقارنة الانترال هم في حرص عالي
+
+63
+00:05:24,890 --> 00:05:32,270
+للتطور من ديابتا إذا كان ال Hemoglobin A1C أعلى من
+
+64
+00:05:32,270 --> 00:05:38,070
+6.5 معناته هذا الشخص دياباتيك
+
+65
+00:05:39,420 --> 00:05:45,840
+وإذا أقل من 5.7 normal يبقى إذا كان فحصنا الـ
+
+66
+00:05:45,840 --> 00:05:50,860
+hemoglobin A1C ولاجيناها بين 5.7 على 6.4 يبقى برضه
+
+67
+00:05:50,860 --> 00:05:56,020
+هذا اللي هو الشخص اللي في مرحلة الـ pre-diabetes
+
+68
+00:05:56,020 --> 00:06:03,480
+وعنده ال risk عالي للإصابة بالـ diabetes يبقى
+
+69
+00:06:03,480 --> 00:06:09,390
+عندنا أكتر من فحص ممكن يتم استخدامهمو ممكن من
+
+70
+00:06:09,390 --> 00:06:16,010
+خلالهم نحدد الناس اللي يعني أكتر عرضة أو at higher
+
+71
+00:06:16,010 --> 00:06:22,250
+risk للإصابة بالـ diabetes بالنسبالي
+
+72
+00:06:22,250 --> 00:06:28,870
+الهرمونات اللي بتنظم مستوى ال blood glucose في
+
+73
+00:06:28,870 --> 00:06:34,680
+عندنا نوعين من الهرمونات في عندناالـ Hypoglycemic
+
+74
+00:06:34,680 --> 00:06:41,360
+Hormones وفينا الـ Hyperglycemic Hormones الـ
+
+75
+00:06:41,360 --> 00:06:45,680
+Hypoglycemic Hormones طبعا إنها هرمون وحيد هو الـ
+
+76
+00:06:45,680 --> 00:06:50,620
+Insulin بهذا الهرمون الوحيد اللي بيعمل على تخفيد
+
+77
+00:06:50,620 --> 00:06:55,740
+مستوى الجلوكوز في الدم بينما الـ Hyperglycemic
+
+78
+00:06:55,740 --> 00:07:02,610
+Hormones إنها هرمونات عديدة بتعمل على رفعمستوى
+
+79
+00:07:02,610 --> 00:07:08,410
+الجلوكوز في الدم زي عندنا طبعا ال glucagon ال
+
+80
+00:07:08,410 --> 00:07:13,990
+epinephrine عندنا ال growth hormone ال cortisol
+
+81
+00:07:13,990 --> 00:07:19,550
+بيادة كلها هرمونات بتعمل على زيادة مستوى الجلوكوز
+
+82
+00:07:19,550 --> 00:07:21,190
+في الدم
+
+83
+00:07:30,410 --> 00:07:37,970
+Normal glucose disposal depends on يبقى عشان ال ..
+
+84
+00:07:37,970 --> 00:07:44,890
+ال glucose اللي بيدخله الدم عشان نقدر نخفضه يبقى
+
+85
+00:07:44,890 --> 00:07:51,090
+لابد انه يكون عندنا الأمور التالية الأمر الأول the
+
+86
+00:07:51,090 --> 00:07:55,250
+ability of the pancreas to secrete insulin يبقى
+
+87
+00:07:55,250 --> 00:07:58,090
+لازم يكون فيه قدرة لقى ال pancreas طبعا على إفراز
+
+88
+00:07:58,090 --> 00:08:02,540
+ال insulinوالنقطة التانية ability of insulin to
+
+89
+00:08:02,540 --> 00:08:06,100
+promote uptake of glucose into peripheral tissue
+
+90
+00:08:06,100 --> 00:08:11,000
+يبقى النقطة التانية اللي هو انه ال insulin action
+
+91
+00:08:11,000 --> 00:08:17,260
+يرتبط ال insulin مع الخلايا وفعليا يعمل على دخول
+
+92
+00:08:17,260 --> 00:08:23,320
+ال glucose للخلايا المختلفة والنقطة التالتة the
+
+93
+00:08:23,320 --> 00:08:26,060
+ability of insulin to suppress hepatic glucose
+
+94
+00:08:26,060 --> 00:08:32,080
+production يبقى برضهبدناش يعني زي لأن الجلوكوز
+
+95
+00:08:32,080 --> 00:08:37,440
+عالي بيبدناه يتوقف الكبد عن إنتاج الجلوكوز بيبقى
+
+96
+00:08:37,440 --> 00:08:41,780
+برضه هذا بيتم اللي هو تحت تأثير الانسولين اللي
+
+97
+00:08:41,780 --> 00:08:49,440
+بيعمل suppression لخروج الجلوكوز من الكبد the
+
+98
+00:08:49,440 --> 00:08:52,200
+major insulin target organs are liver, skeletal
+
+99
+00:08:52,200 --> 00:08:55,500
+muscle and adipose tissue بيهدي ال tissues
+
+100
+00:08:55,500 --> 00:09:01,100
+المختلفة اللي بيشتغل عليهاmainly ال insulin these
+
+101
+00:09:01,100 --> 00:09:03,680
+organs is exhibit some differences in their
+
+102
+00:09:03,680 --> 00:09:08,500
+response to insulin يبقى التلاتة بيستجيبوا لال
+
+103
+00:09:08,500 --> 00:09:14,760
+insulin لكن الاستجابة مش متشابهة يبقى فيه انه بعض
+
+104
+00:09:14,760 --> 00:09:19,780
+الاختلاف في الاستجابة لال tissuesالمختلفة for
+
+105
+00:09:19,780 --> 00:09:23,120
+example the hormone stimulates glucose uptake
+
+106
+00:09:23,120 --> 00:09:26,160
+through a specific glucose transporter اللي هو
+
+107
+00:09:26,160 --> 00:09:32,040
+glut4 into muscle and fat cells but not into liver
+
+108
+00:09:32,040 --> 00:09:37,640
+cells يبقى ال glucose transporters ممكن يختلف من
+
+109
+00:09:37,640 --> 00:09:43,480
+tissue إلى آخر بينما
+
+110
+00:09:43,480 --> 00:09:46,540
+في ال liver تحتاج إلى transporter آخر اللي هو
+
+111
+00:09:46,540 --> 00:09:47,800
+glut2
+
+112
+00:09:49,830 --> 00:09:55,790
+طيب نحكي شوية عن ال hormone الانسولين و عن ال
+
+113
+00:09:55,790 --> 00:10:02,130
+synthesis و ال degradation لهذا ال hormone عبارة
+
+114
+00:10:02,130 --> 00:10:08,090
+عن خمس تلاف و تمانية و تمانية دالتون بروتين بتكون
+
+115
+00:10:08,090 --> 00:10:13,530
+من واحد و خمسين amino acid و بتكون من two chains
+
+116
+00:10:13,530 --> 00:10:21,960
+ان ال chain Aبالأحمر وهي عندنا ال chain B وهدول ال
+
+117
+00:10:21,960 --> 00:10:25,960
+two chains مرتبطين مع بعضهم البعض اللي هو عن طريق
+
+118
+00:10:25,960 --> 00:10:33,800
+disulfide bridge بالنسبالي
+
+119
+00:10:33,800 --> 00:10:40,010
+ال insulin اللي موجود عند الإنسانالـ amino acid
+
+120
+00:10:40,010 --> 00:10:43,910
+sequence لالـ human insulin differs slightly from
+
+121
+00:10:43,910 --> 00:10:50,270
+insulin of other species فينا اختلاف في لوباط ال
+
+122
+00:10:50,270 --> 00:10:58,270
+amino acids لكن فينا مناطق متشابهة بالانسولين سواء
+
+123
+00:10:58,270 --> 00:11:03,340
+الموجود بالإنسان أو الموجود فياللي هو other
+
+124
+00:11:03,340 --> 00:11:07,600
+species the carboxyl terminal region of the B
+
+125
+00:11:07,600 --> 00:11:16,200
+chain اللي هي المنطقة من B23 ل B26 هذه appears
+
+126
+00:11:16,200 --> 00:11:20,420
+crucial for the biological action of insulin ومهمة
+
+127
+00:11:20,420 --> 00:11:24,120
+العمل للإنسلين وبالتالي هذه المنطقة highly
+
+128
+00:11:24,120 --> 00:11:29,960
+conserved among species يبقى يعني تم اللي هو
+
+129
+00:11:29,960 --> 00:11:35,390
+المحافظة عليها ومتشابهةفي الانسلين الموجود في ال
+
+130
+00:11:35,390 --> 00:11:40,990
+different species بنسبالها
+
+131
+00:11:40,990 --> 00:11:44,950
+الانسلين senses انسلين from most animals is
+
+132
+00:11:44,950 --> 00:11:49,610
+immunologically and biologically similar to human
+
+133
+00:11:49,610 --> 00:11:53,970
+insulin and in the past patients were treated with
+
+134
+00:11:53,970 --> 00:12:00,270
+insulin purified from beef or pig cancersلأن زي ما
+
+135
+00:12:00,270 --> 00:12:05,770
+قلنا إن في منطقة اللي هي conserved ويعني
+
+136
+00:12:05,770 --> 00:12:09,910
+بالتالي المنطقة هذه موجودة بال different species
+
+137
+00:12:09,910 --> 00:12:14,550
+وبالتالي تم استخدام insulin بينتج من حيوانات زي
+
+138
+00:12:14,550 --> 00:12:18,490
+اللي هو الأبقار أو اللي هو العجول أو الخنزير
+
+139
+00:12:18,490 --> 00:12:24,570
+لمعالجة أو للحصول على insulin لمعالجة المرضى لكن
+
+140
+00:12:24,570 --> 00:12:29,120
+الآن طبعا بيتم اللي هو إنتاجالانسولين اللي هو من
+
+141
+00:12:29,120 --> 00:12:34,600
+خلال ال .. اللي هو ال .. ال recomponent اللي هو
+
+142
+00:12:34,600 --> 00:12:38,880
+DNA techniques هيبقى عندنا اللي .. اللي موجود اللي
+
+143
+00:12:38,880 --> 00:12:46,540
+هو recomponent human insulin أول
+
+144
+00:12:46,540 --> 00:12:54,580
+منتج بيتم الحصول عليه أو أول protein بيتم الحصول
+
+145
+00:12:54,580 --> 00:13:00,770
+عليه هو ال pre pro insulinإبارة عن بروتين بتكون من
+
+146
+00:13:00,770 --> 00:13:05,250
+meat amino acid formed by ribosomes in the rough
+
+147
+00:13:05,250 --> 00:13:09,730
+endoplasmic reticulum of the pancreatic beta cells
+
+148
+00:13:09,730 --> 00:13:12,870
+pre
+
+149
+00:13:12,870 --> 00:13:16,570
+-proinsulin is not detectable in the circulation
+
+150
+00:13:16,570 --> 00:13:23,390
+لو بحثت عن ال pre-proinsulin مش هنلاقيه موجود
+
+151
+00:13:23,390 --> 00:13:30,080
+بالcirculation بظروف الطبيعية لأنهمباشرة وبشكل
+
+152
+00:13:30,080 --> 00:13:37,560
+سريع بيصيرله Eclivage وبيتحول إلى Proinsulin اللي
+
+153
+00:13:37,560 --> 00:13:43,560
+عبارة عن بروتين بتكون من ستة و تمانين amino acid
+
+154
+00:13:43,560 --> 00:13:47,740
+يعني أول بروتين بينتج من ال pre-proinsulin ميت
+
+155
+00:13:47,740 --> 00:13:56,690
+amino acidمباشرة في سلّه cleavage اللي هو بيتم قطع
+
+156
+00:13:56,690 --> 00:14:00,570
+أربعة عشر amino acid وبيعطيني بروانسولين اللي هو
+
+157
+00:14:00,570 --> 00:14:04,850
+عبارة عن ستة و تمانين amino acid بالروتين
+
+158
+00:14:08,440 --> 00:14:13,600
+هذا مقفل في مجزرات مخصصة في مجلس الجيولوجيا لـ
+
+159
+00:14:13,600 --> 00:14:17,980
+Beta-cells حيث يحدث تنقل البروتراتيكي لالإنسلين
+
+160
+00:14:17,980 --> 00:14:24,290
+ومشاركة بيبتايدطبعا أي شيء بده يتم .. بده يصلله
+
+161
+00:14:24,290 --> 00:14:32,510
+secretion من الخلايا يبقى المفروض أنه طبعا ببدأ ..
+
+162
+00:14:32,510 --> 00:14:36,450
+بداية بيصله translation من خلال ال .. ال rough
+
+163
+00:14:36,450 --> 00:14:43,230
+endoplasmic reticulum و هذا ال protein بيكون موجود
+
+164
+00:14:43,230 --> 00:14:46,950
+في داخل physical و ال physical ذاتي بتتجه ل ال
+
+165
+00:14:46,950 --> 00:14:52,320
+geology اللي هو complex وهناك اللي هو بيصير في عنا
+
+166
+00:14:52,320 --> 00:14:57,080
+modification لهذه البروتينات وبعدين بيصير release
+
+167
+00:14:57,080 --> 00:15:03,660
+لهذه ال proteins في داخل vesicles عشان بعد هيك
+
+168
+00:15:03,660 --> 00:15:08,540
+يصلها اللي هو execution إلى خارج الخلية
+
+169
+00:15:11,740 --> 00:15:16,060
+يبقى عشان نحصل على الـ Insulin لابد أن نصير عندنا
+
+170
+00:15:16,060 --> 00:15:24,260
+Eclavage لـ C-Peptide وهذا الـ Eclavage بيتم من
+
+171
+00:15:24,260 --> 00:15:30,900
+خلال enzymes اللي يتسمى Pro-Hormone Convertases I
+
+172
+00:15:30,900 --> 00:15:37,880
+and IIعبارة عن Endopeptidases يبقى بيقطعوا في اللي
+
+173
+00:15:37,880 --> 00:15:45,160
+هو داخل البروتين وبيعملوا قطع لـ C-peptide عشان
+
+174
+00:15:45,160 --> 00:15:53,160
+نحصل على الانسلين يبقى أن ال enzyme pro hormone
+
+175
+00:15:53,160 --> 00:16:00,420
+convertase I بيجي وبيرتبط على الـ C-terminal end
+
+176
+00:16:00,420 --> 00:16:12,040
+الاند اللي هو RGN 31 وRGN 32وبيعمل قطع بين
+
+177
+00:16:12,040 --> 00:16:20,380
+الـ amino acid رقم 32 و33 وبيعطينا
+
+178
+00:16:20,380 --> 00:16:28,680
+له split 32 33 Pro-insulin عندنا
+
+179
+00:16:28,680 --> 00:16:30,880
+الـ enzyme الأخر اللي هو الـ Pro-hormone
+
+180
+00:16:30,880 --> 00:16:35,510
+converterase-2بيعمل cleavage في مكان آخر Cleaves
+
+181
+00:16:35,510 --> 00:16:39,210
+Pro Insulin on the c-terminal side of the basic
+
+182
+00:16:39,210 --> 00:16:45,810
+residues Lysine 64 وArginine 65 to generate split
+
+183
+00:16:45,810 --> 00:16:52,230
+65 and 66 Pro Insulin يجب يقطع بين ال amino acid
+
+184
+00:16:52,230 --> 00:16:55,790
+65 و ال amino acid 66
+
+185
+00:16:59,890 --> 00:17:07,630
+بعد ما بتتم عملية القطع بيصير فيه removal لـ two
+
+186
+00:17:07,630 --> 00:17:15,330
+exposed amino acids removal of two newly exposed C
+
+187
+00:17:15,330 --> 00:17:21,410
+-terminal basic amino acids واللي بيعمل ال removal
+
+188
+00:17:21,410 --> 00:17:26,270
+لهذه ال amino acids انزايم يسمى Carboxypeptidase-H
+
+189
+00:17:28,560 --> 00:17:34,240
+وبعدما تتم عملية القطع وعملية الـ removal لـ الـ
+
+190
+00:17:34,240 --> 00:17:39,920
+two amino acids هذه بينتج عندنا الـ Insulin و الـ
+
+191
+00:17:39,920 --> 00:17:46,300
+C-peptide يبقى
+
+192
+00:17:46,300 --> 00:17:50,380
+زي ما هو واضح عندنا بال figure هان هان اللي هو الـ
+
+193
+00:17:50,380 --> 00:17:54,720
+Pro-insulin هان عندنا اللي هو الـ A-chain و الـ B
+
+194
+00:17:54,720 --> 00:17:56,500
+-chain و هان الـ C-peptide
+
+195
+00:18:02,900 --> 00:18:08,600
+و عشان نحصل على ال insulin لابد من قطع ال C
+
+196
+00:18:08,600 --> 00:18:14,720
+-peptide زى ما قولنا أنه في عندنا two enzymes في
+
+197
+00:18:14,720 --> 00:18:21,640
+عندنا ال P-C-I هذا بيقطع بين العمينا أسل 32 و 33
+
+198
+00:18:21,640 --> 00:18:28,160
+زى ما هو واضح هان تمام بيبقى بيصير عندنا قطع هان
+
+199
+00:18:29,070 --> 00:18:34,310
+وعنا الانزيم الأخر اللي هو ال PC2 بيقطع بين اللي
+
+200
+00:18:34,310 --> 00:18:45,850
+هو خمسة وستين وستة وستين تمام
+
+201
+00:18:45,850 --> 00:18:52,950
+يبقى PC1 بيقطع بين 32 و33 وبنحصل
+
+202
+00:18:52,950 --> 00:18:57,780
+على اللي هو split 32 و33 Proinsulinبعد هيك عندنا
+
+203
+00:18:57,780 --> 00:19:02,900
+ال enzyme ال CBH زمولنا بيعمل removal ل ال two
+
+204
+00:19:02,900 --> 00:19:10,620
+amino acids و بنحصل على this 3130-t-pro-insulin و
+
+205
+00:19:10,620 --> 00:19:18,560
+عندنا بعد هيك ال enzyme الاخر اللي بيعمل قطع ل ال
+
+206
+00:19:18,560 --> 00:19:22,560
+.. اللي هو ال .. ال c-peptide من الناحية الأخرى
+
+207
+00:19:22,560 --> 00:19:28,570
+اللي بيقطع بين اربعة و ستة .. بينبين 64 و 65 و
+
+208
+00:19:28,570 --> 00:19:32,030
+بعدين بيصير برضه عندنا عن طريق ال و CpH بيصير
+
+209
+00:19:32,030 --> 00:19:39,800
+removal ل اللي هو ال two amino acidsفي عندنا two
+
+210
+00:19:39,800 --> 00:19:44,220
+pathways لهذه العملية عندنا الـ major pathway اللي
+
+211
+00:19:44,220 --> 00:19:52,180
+بتتم اللي هو بداية اللي قطع الـ PC1 بين الـ amino
+
+212
+00:19:52,180 --> 00:19:57,700
+acids 32 و33 أو 30 و بتتكمل العملية وفي عندنا ال
+
+213
+00:19:57,700 --> 00:20:05,140
+minor pathway اللي هو بيبدأ القطع بالـ PC2 و بيصير
+
+214
+00:20:05,140 --> 00:20:09,470
+بعد ذلك removal للـ twoأمينو أسيد و بعدين بيصير
+
+215
+00:20:09,470 --> 00:20:14,410
+عندنا قطع مرة أخرى ب ال PC-1 و removal ال two
+
+216
+00:20:14,410 --> 00:20:20,410
+amino acids عن طريق ال واسي pH و بنحصل بالنهاية
+
+217
+00:20:20,410 --> 00:20:29,050
+على انسولين و على ال C-peptide من
+
+218
+00:20:29,050 --> 00:20:37,080
+خلال الأبحاثلجوا انه لو صار في incubation لـ
+
+219
+00:20:37,080 --> 00:20:43,960
+Proinsulin مع ال BC-1 فقط لجوا انه ال BC-1 فعليا
+
+220
+00:20:43,960 --> 00:20:49,620
+بيعمل القطعين المطلوبين تمام بيعمل القطع اللي هو
+
+221
+00:20:49,620 --> 00:20:58,290
+بين32 و بين 33 و بين الـ 65 و بين اللي هو الـ 66
+
+222
+00:20:58,290 --> 00:21:03,790
+يبقى الـ BC1 قادر على أنه يقطع في هدول المنطقتين
+
+223
+00:21:03,790 --> 00:21:15,490
+بينما الـ BC2 لجوا أنه بيقطع فقط في هذه المنطقة زي
+
+224
+00:21:15,490 --> 00:21:18,450
+ما ذكرنا في الـ slider السابقة أنه في عندنا اللي
+
+225
+00:21:18,450 --> 00:21:19,590
+هو الـ minor pathway
+
+226
+00:21:22,170 --> 00:21:26,510
+وإنه less than 10% of pro-insulin is metabolized
+
+227
+00:21:26,510 --> 00:21:32,590
+via this 6465 pro-insulin which is present in
+
+228
+00:21:32,590 --> 00:21:37,250
+negligible amounts in humans المهم يا دي اللي هو
+
+229
+00:21:37,250 --> 00:21:41,930
+ال minor part و بينما إن this 3132 pro-insulin is
+
+230
+00:21:41,930 --> 00:21:46,510
+the major pro-insulin conversion intermediate
+
+231
+00:21:48,760 --> 00:21:53,560
+الجلوكوز هو اللي بيتحكم بيه الـ Synthesis لـ الـ
+
+232
+00:21:53,560 --> 00:21:58,460
+Proinsulin و أيضًا للإنزايم اللي هو الـ PC-1 اللي
+
+233
+00:21:58,460 --> 00:22:04,180
+بيعمل القطع و تحويه اللي بيحول الـ Proinsulin إلى
+
+234
+00:22:04,180 --> 00:22:08,540
+Insulinيبقى الـ Glucose regulates biosynthesis of
+
+235
+00:22:08,540 --> 00:22:14,000
+both Proinsulin and BC-1 لكن مالهوش أي تأثير على
+
+236
+00:22:14,000 --> 00:22:21,520
+الـ BC-2 أو على الـ Carboxypeptidase H يبقى بعد ما
+
+237
+00:22:21,520 --> 00:22:24,460
+اللي هو اتم انه عملية القطع بعد ذلك بيصير فيه انه
+
+238
+00:22:24,460 --> 00:22:29,800
+Exocytosis و بيصير فيه Release للإنسلين و للـ C
+
+239
+00:22:29,800 --> 00:22:30,640
+-Peptide
+
+240
+00:22:33,200 --> 00:22:40,440
+وبيدخلوا للكبد عن طريق ال portal circulation يبقى
+
+241
+00:22:40,440 --> 00:22:44,980
+بيصير فيه inner release وبيدخلوا للو الدم وبيدخلوا
+
+242
+00:22:44,980 --> 00:22:49,300
+للكبد عن طريق ال portal circulation و بعدين طبعا
+
+243
+00:22:49,300 --> 00:22:54,760
+بيصلوا إلى جميع أجزاء الجسم
+
+244
+00:22:56,750 --> 00:23:01,410
+بالإضافة للإنسولين والـ C-peptide برضه بنلاقي
+
+245
+00:23:01,410 --> 00:23:06,110
+small amounts of pro-insulin ومن ال intermediate
+
+246
+00:23:06,110 --> 00:23:12,970
+cleavage forms هدول بنلاقيهم برضه موجودين في ال
+
+247
+00:23:12,970 --> 00:23:17,250
+circulation طيب،
+
+248
+00:23:17,250 --> 00:23:21,470
+إيش ال stimulus أو ال signal اللي بتؤدي إلى ال
+
+249
+00:23:21,470 --> 00:23:26,700
+release of insulin؟الجلوكوز is the most important
+
+250
+00:23:26,700 --> 00:23:32,800
+physiological secretagogue for
+
+251
+00:23:32,800 --> 00:23:37,700
+insulin يبقى هو ال substance that promotes
+
+252
+00:23:37,700 --> 00:23:41,060
+secretion of insulin الجلوكوز substance that
+
+253
+00:23:41,060 --> 00:23:45,600
+promotes the secretion of insulin يبقى الزيادة
+
+254
+00:23:45,600 --> 00:23:52,140
+لبلد في البلد الجلوكوز بيعمل stimulationللـ beta
+
+255
+00:23:52,140 --> 00:23:57,680
+cells عشان تعمل اللي هو secretion للإنسلين وهذا
+
+256
+00:23:57,680 --> 00:24:01,140
+بيصير within minutes insulin release is
+
+257
+00:24:01,140 --> 00:24:06,420
+potentiated by substances such as the encretin
+
+258
+00:24:06,420 --> 00:24:13,680
+hormones يعني ان في شغلات برضه هذه بتزيد من إفراز
+
+259
+00:24:14,120 --> 00:24:17,560
+الانسولين زي عندنا الانكريتين hormones عبارة عن
+
+260
+00:24:17,560 --> 00:24:23,980
+مجموعة من الهرمونات اللي بيصلها release بعد الأكل
+
+261
+00:24:23,980 --> 00:24:29,200
+بجهة الهرمونات لما الإنسان بيتناول اللي هو الطعام
+
+262
+00:24:29,200 --> 00:24:34,220
+بيصير فيه عندنا release ل الانكريتين hormones زي
+
+263
+00:24:34,220 --> 00:24:37,440
+اللي هو ال glucagon-like peptide و ال glucose
+
+264
+00:24:37,440 --> 00:24:41,320
+-dependent insulinotropic polypeptide
+
+265
+00:24:42,100 --> 00:24:49,440
+و«كوليسايتوكاينين بيبتايد YY» و«إكزينتوموديولين»
+
+266
+00:24:49,440 --> 00:24:53,100
+كلها هذي هرمونات بس اللي ها release بعد تناول
+
+267
+00:24:53,100 --> 00:25:00,380
+الطعام وهذه الهرمونات كلها بتزيد من ال release
+
+268
+00:25:00,380 --> 00:25:02,300
+للإنسيلين
+
+269
+00:25:04,000 --> 00:25:07,940
+في المقابل إنه العديد من العوامل اللي بتعمل
+
+270
+00:25:07,940 --> 00:25:12,220
+Inhibition لـ Insulin Release ومنها الـ
+
+271
+00:25:12,220 --> 00:25:17,000
+Hypoglycemia يعني انخفاض في مستوى الـ Glucose إنه
+
+272
+00:25:17,000 --> 00:25:21,760
+الـ Somatostatin اللي بيفرز برضه في الـ Pancreas
+
+273
+00:25:21,760 --> 00:25:26,440
+من خلال الـ Delta Cells الموجودة في الـ Pancreas
+
+274
+00:25:26,710 --> 00:25:32,010
+هذا الـ hormone بيعمل اللي هو inhibition على الـ
+
+275
+00:25:32,010 --> 00:25:36,030
+beta cells وبالتالي بيقلل أو بيعمل inhibition للـ
+
+276
+00:25:36,030 --> 00:25:42,650
+release للإنسولين بالإضافة للعديد من ال drugs اللي
+
+277
+00:25:42,650 --> 00:25:47,770
+ممكن بتعمل inhibition للـ release للإنسولين من
+
+278
+00:25:47,770 --> 00:25:52,030
+خلال تأثيرها على ال beta cells
+
+279
+00:25:58,690 --> 00:26:01,690
+in health individuals insulin is released in a
+
+280
+00:26:01,690 --> 00:26:05,610
+pulsatile fashion يبقى بيكون اللي هو عن طريق اللي
+
+281
+00:26:05,610 --> 00:26:11,050
+هو pulses أه يبقى عندنا كل فترة بيصير في release
+
+282
+00:26:11,050 --> 00:26:15,210
+لكمية من ال insulin يبقى في عندنا pulsatile
+
+283
+00:26:15,210 --> 00:26:20,620
+release، pulseswith glucose and insulin the main
+
+284
+00:26:20,620 --> 00:26:25,140
+signals in the feedback loop يبقى هم اللي .. و
+
+285
+00:26:25,140 --> 00:26:28,780
+اللي بتحكمه و اللي بيعملوا اللي هو feedback أو
+
+286
+00:26:28,780 --> 00:26:31,240
+negative feedback على ال .. ال release اللي
+
+287
+00:26:31,240 --> 00:26:35,500
+glucose و ال insulin ال glucose اللي sets the
+
+288
+00:26:35,500 --> 00:26:39,000
+release of insulin from the pancreas into phases
+
+289
+00:26:39,000 --> 00:26:46,220
+يبقى لما بيدخل ال glucose ل الدم بيصير فيه انا
+
+290
+00:26:46,220 --> 00:26:52,210
+release لال insulinبالهو مرحلتين أو على مرحلتين
+
+291
+00:26:52,210 --> 00:27:01,410
+المرحلة الأولى بتبدأ بعد دقيقة إلى دقيقتين من دخول
+
+292
+00:27:01,410 --> 00:27:09,310
+الـ glucose للدم و بتنتهي عند عشر دقائق المرحلة
+
+293
+00:27:09,310 --> 00:27:13,330
+الأولى بتبدأ يعني بشكل سريع بعد دقيقة أو دقيقتين
+
+294
+00:27:13,890 --> 00:27:18,590
+وبتنتهي عند عشر دقائق وبهذه المرحلة بيكون في عندنا
+
+295
+00:27:18,590 --> 00:27:23,190
+release لكمية كبيرة من الانسولين يبقى sharp spike
+
+296
+00:27:23,190 --> 00:27:29,130
+represent the rapid release of stored insulin يبقى
+
+297
+00:27:29,130 --> 00:27:34,290
+بيصير release لكمية كبيرة من الانسولين بعد هيك
+
+298
+00:27:34,290 --> 00:27:38,070
+بتدخل المرحلة التانية beginning at the point where
+
+299
+00:27:38,070 --> 00:27:44,010
+the first phase ended بتبدأ بعد العشر دقائقوبتستمر
+
+300
+00:27:44,010 --> 00:27:50,030
+لغاية ما يرجع مستوى الـ glucose في الدم إلى
+
+301
+00:27:50,030 --> 00:27:58,570
+المستوى الطبيعي وهذه ممكن تستمر يعني لمدة 60 إلى
+
+302
+00:27:58,570 --> 00:28:08,940
+120 دقيقة أو يعني تنتهي بعد 60 إلى 120 دقيقةهذا
+
+303
+00:28:08,940 --> 00:28:15,200
+الـ figure بيوضح استجابة أو
+
+304
+00:28:15,200 --> 00:28:20,060
+الـ concentration للـ الانسولين بناء على ال
+
+305
+00:28:20,060 --> 00:28:28,060
+injection لجلوكوز في الدم يبين هنا إنه كمية
+
+306
+00:28:28,060 --> 00:28:34,720
+الانسولين اللي صلها detection في الدم و هنا إنه ال
+
+307
+00:28:34,720 --> 00:28:42,190
+timeهنا إن هو شخص طبيعي وزي ما قلنا إنه بيصير فيه
+
+308
+00:28:42,190 --> 00:28:48,750
+إنه release للإنسولين على مرحلتين هان اللي هو كمية
+
+309
+00:28:48,750 --> 00:28:54,310
+الإنسولين قبل ما يتم حقن الشخص بعشرين جرام من ال
+
+310
+00:28:54,310 --> 00:28:59,630
+glucose هان عند سفر صار إن عملية الحقنزي ما أحنا
+
+311
+00:28:59,630 --> 00:29:03,990
+شايفين أنه بتبدأ عندنا ال phase one المرحلة الأولى
+
+312
+00:29:03,990 --> 00:29:07,930
+زي ما قلنا خلال دقيقة إلى دقيقتين بيصير في عندي ال
+
+313
+00:29:07,930 --> 00:29:14,730
+release ل اللي هو كمية كبيرة من ال incidentبعد هيك
+
+314
+00:29:14,730 --> 00:29:18,050
+بعد وهذه بتستمر ل تقريبا عشر دقائق بعد هيك بتبدأ
+
+315
+00:29:18,050 --> 00:29:22,850
+عندي ال concentration ل ال insulin قل بنبدأ بيه
+
+316
+00:29:22,850 --> 00:29:27,670
+المرحلة التانية كل ما نزل ال glucose concentration
+
+317
+00:29:27,670 --> 00:29:33,650
+كل ما قلت كمية ال insulin الموجودة لغاية ما ترجع
+
+318
+00:29:33,650 --> 00:29:39,070
+كمية اللي هو ال insulin ل ال basal levels عندما
+
+319
+00:29:39,070 --> 00:29:44,940
+ترجع اللي هو ال concentration ل glucoseإلى المستوى
+
+320
+00:29:44,940 --> 00:29:50,860
+الطبيعي ال figures التانية اللي هو انها figure B
+
+321
+00:29:50,860 --> 00:29:57,780
+هذا بيوضح كمية ال insulin عند شخص مصاب بال type 2
+
+322
+00:29:57,780 --> 00:30:01,640
+diabetes mellitus و الناس المصابين بال type 2
+
+323
+00:30:01,640 --> 00:30:07,040
+diabetes mellitus بيفقدوا phase one بيكونش موجود
+
+324
+00:30:07,040 --> 00:30:13,730
+عندهم phase one عشان هيكلما بيتناولوا الـ
+
+325
+00:30:13,730 --> 00:30:18,610
+carbohydrates وبيدخل الجلوكوز للدم بنلاقي أنه بيظل
+
+326
+00:30:18,610 --> 00:30:23,150
+الـ الـ الـ glucose concentration مرتفعة فترة
+
+327
+00:30:23,150 --> 00:30:28,430
+طويلة في الدم لأنه الـ phase one المرحلة الأولى
+
+328
+00:30:28,430 --> 00:30:34,470
+مهمة ليه اللي هو خفض مستوى السكر سريعا لأن زي ما
+
+329
+00:30:34,470 --> 00:30:38,070
+قلنا بيصير release لكمية كبيرة من الانسولين و اللي
+
+330
+00:30:38,070 --> 00:30:44,370
+هو بشكل سريع لكن الـ type twoالـ diabetic patients
+
+331
+00:30:44,370 --> 00:30:48,730
+الـ phase one مش موجودة عندهم يعني جهان عند سفر
+
+332
+00:30:48,730 --> 00:30:53,330
+صار فيه عندي اللي هو injection لعشرين جرام من
+
+333
+00:30:53,330 --> 00:30:57,210
+الجلوكوز زي ما أحنا شايفين أنه مافيش عندنا spike
+
+334
+00:30:57,210 --> 00:31:01,770
+زي ما صار في هان يبقى ال phase one مش موجودة لكن
+
+335
+00:31:01,770 --> 00:31:08,150
+ال phase two موجودة بيبدأ بيرتفع عندنا ال insulin
+
+336
+00:31:11,130 --> 00:31:18,650
+و زي ما حكينا إنه هذا بياخد يعني فترات طويلة
+
+337
+00:31:18,650 --> 00:31:27,430
+للوصول إلى ال normal concentration يعني
+
+338
+00:31:27,430 --> 00:31:30,270
+لأ طبعا بال type 2 diabetes مش هيصل ل ال normal
+
+339
+00:31:30,270 --> 00:31:34,670
+يعني عشان يخفض ال glucose لكن طبعا مش هيصل ل ال
+
+340
+00:31:34,670 --> 00:31:41,520
+normal هيظل لنا ال glucose مرتفعبينما بي ال
+
+341
+00:31:41,520 --> 00:31:45,920
+patients with type 1 طبعا إنا مشكلة أصلا إحنا في
+
+342
+00:31:45,920 --> 00:31:52,280
+ال release of insulin لأنه عندنا اللي هو صار في
+
+343
+00:31:52,280 --> 00:31:56,040
+destruction ل ال beta cells وبالتالي يعني ال
+
+344
+00:31:56,040 --> 00:31:59,720
+insulin مش موجود أو موجود يعني ب very low
+
+345
+00:31:59,720 --> 00:32:00,860
+concentrations
+
+346
+00:32:03,380 --> 00:32:06,720
+يبقى زي ما شوفنا في ال figure الصابق with
+
+347
+00:32:06,720 --> 00:32:09,360
+progressive failure of beta cell function first
+
+348
+00:32:09,360 --> 00:32:15,740
+phase insulin response للجلوكوز is lost لكن أن ال
+
+349
+00:32:15,740 --> 00:32:21,060
+second phase بتظل اللي موجودة is preserved both
+
+350
+00:32:21,060 --> 00:32:23,520
+the first phase response and normal pulsatile
+
+351
+00:32:23,520 --> 00:32:26,760
+insulin secretion are lost يبقى ال first phase
+
+352
+00:32:26,760 --> 00:32:32,790
+بيفقد ال pulsatile insulin secretion بيفقدلكن الـ
+
+353
+00:32:32,790 --> 00:32:39,550
+second phase بتظل موجودة وطبعا ال word type one
+
+354
+00:32:39,550 --> 00:32:44,510
+أنه أصلا مشكلة في ال release للإنسلين وبالتالي
+
+355
+00:32:44,510 --> 00:32:50,110
+minimal or no insulin response النقطة التالية ال
+
+356
+00:32:50,110 --> 00:32:51,750
+insulin degradation
+
+357
+00:32:56,300 --> 00:32:58,660
+على الطريق الأول من خلال الـ Portal Circulation
+
+358
+00:32:58,660 --> 00:33:04,300
+نحن زي ما قلنا أنه بيصير فيه إطلاق للإنسلين بيدخل
+
+359
+00:33:04,300 --> 00:33:09,160
+للكبد عن طريق الـ Portal Circulation يبقى عندنا
+
+360
+00:33:09,160 --> 00:33:12,040
+الطريق الأول من خلال الـ Portal Circulation
+
+361
+00:33:12,040 --> 00:33:20,050
+تقريبًا 50% من الإنسلين يتم إخراجه من الجلديعني
+
+362
+00:33:20,050 --> 00:33:25,530
+where it is degraded يعني مش ممكن ال .. يعني مش كل
+
+363
+00:33:25,530 --> 00:33:29,030
+الكمية ممكن تستخدم ال degradation يعني ممكن يصير
+
+364
+00:33:29,030 --> 00:33:32,950
+فيه فعليًا extraction لخمسين بالمية من الانسولين
+
+365
+00:33:32,950 --> 00:33:41,390
+لكن ممكن يصير لاحقًا release لبعض من هذه الكمية
+
+366
+00:33:41,390 --> 00:33:46,630
+مرة أخرى لل circulation هو يعني مش كتير دقيقة أنه
+
+367
+00:33:46,990 --> 00:33:51,570
+الخمسين بالمية هذه بيصير لـ degradation يبقى بيصير
+
+368
+00:33:51,570 --> 00:33:55,410
+فيه extraction لخمسين بالمية من الانسلين لكن ممكن
+
+369
+00:33:55,410 --> 00:33:59,930
+لاحقا بعض من هذه الكمية اللي صارت ال extraction
+
+370
+00:33:59,930 --> 00:34:04,190
+ممكن ترجع تدخل ل ال circulation مرة أخرى
+
+371
+00:34:04,190 --> 00:34:07,370
+additional insulin degradation occurs in the
+
+372
+00:34:07,370 --> 00:34:12,300
+kidneysوعملية الـ degradation ها بتصير فيه الـ
+
+373
+00:34:12,300 --> 00:34:17,280
+tubules وبيه الـ proximal tubules بشكل خاص يبقى
+
+374
+00:34:17,280 --> 00:34:21,580
+بيصير فيه عندنا filtration للإنسلين عن طريق الـ
+
+375
+00:34:21,580 --> 00:34:27,760
+glomeruli بعد هيك بيصير فيه reabsorption للإنسلين
+
+376
+00:34:27,760 --> 00:34:31,520
+بيه ال proximal convoluted tubule وبتصير
+
+377
+00:34:31,520 --> 00:34:37,000
+degradation للإنسلين في داخل خلايا ال proximal
+
+378
+00:34:37,000 --> 00:34:38,620
+convoluted tubule
+
+379
+00:35:01,390 --> 00:35:07,330
+بنسبة لها الـ Pro Insulin بشكل طبيعي انها عدد صغير
+
+380
+00:35:09,190 --> 00:35:13,870
+of proinsulin enter the circulation لتقريبا تلاتة
+
+381
+00:35:13,870 --> 00:35:18,310
+بالمية of the amount of insulin بتلاتة بالمية من
+
+382
+00:35:18,310 --> 00:35:21,230
+كمية ال insulin اللي بتدخل اللي هو عندنا بتكون
+
+383
+00:35:21,230 --> 00:35:25,830
+عبارة عن ال proinsulin لكن بالنسبة لل proinsulin
+
+384
+00:35:25,830 --> 00:35:29,310
+ال hepatic clearance rate for proinsulin is only
+
+385
+00:35:29,310 --> 00:35:34,630
+25% of that for insulin يعني عندنا ال clearance
+
+386
+00:35:34,630 --> 00:35:41,940
+أقل مقارنة بالإنسلينوبالمقابل أيضًا الـ half-life
+
+387
+00:35:41,940 --> 00:35:47,260
+لـ الـ Proinsulin تقريبًا تلاتين دقيقة يبقى ال
+
+388
+00:35:47,260 --> 00:35:50,320
+clearance اللي بقت ال clearance أقل مقارنة
+
+389
+00:35:50,320 --> 00:35:54,400
+بالإنسلين ال half-life لالـ Proinsulin أعلى
+
+390
+00:35:54,400 --> 00:36:01,320
+تقريبًا بست مرات من الانسلين وبالتاليخلال اللي هو
+
+391
+00:36:01,320 --> 00:36:04,420
+الـ fasting state ممكن نلاقي إن الـ circulating
+
+392
+00:36:04,420 --> 00:36:10,100
+pro-insulin concentration approximately 10% to 15%
+
+393
+00:36:10,100 --> 00:36:15,800
+of insulin concentration اللي هو بسبب .. زي ما
+
+394
+00:36:15,800 --> 00:36:21,500
+ذكرنا السببين إنه الـ clearance أقل في الكبد و الـ
+
+395
+00:36:21,500 --> 00:36:28,120
+half-life أطول بالنسبة
+
+396
+00:36:28,120 --> 00:36:29,680
+للـ C-peptide
+
+397
+00:36:32,210 --> 00:36:34,850
+was initially thought to be devoid of biological
+
+398
+00:36:34,850 --> 00:36:38,950
+activity وكانوا بال .. بالأول بيفكروا أنه مافيش أي
+
+399
+00:36:38,950 --> 00:36:45,950
+وظيفة مهمة لـ C-peptide and
+
+400
+00:36:45,950 --> 00:36:48,510
+was necessary only to ensure the correct structure
+
+401
+00:36:48,510 --> 00:36:57,150
+of insulin لكن من خلال أبحاث اللي تمتعلى الـ C
+
+402
+00:36:57,150 --> 00:36:59,770
+-peptide لجوا إن الـ C-peptide維س بيولوجيكال
+
+403
+00:36:59,770 --> 00:37:02,550
+activity but its possible physiological
+
+404
+00:37:02,550 --> 00:37:07,010
+significance remains controversally يعني مافيش لسه
+
+405
+00:37:07,010 --> 00:37:11,490
+اتفاق على إيش فعليًا الوظيفة اللي بيقوم فيها الـ C
+
+406
+00:37:11,490 --> 00:37:16,150
+-peptide لكن عديد من الأبحاث بينت إنه في functions
+
+407
+00:37:16,150 --> 00:37:20,470
+مختلفة لـ C-peptide منها اللي هو عملوا كـ
+
+408
+00:37:20,470 --> 00:37:21,930
+antioxidant
+
+409
+00:37:23,940 --> 00:37:29,620
+ويمكن هذا شوية يعني منطقي لأنه طبعا إذا كان
+
+410
+00:37:29,620 --> 00:37:36,320
+ارتفاعنا لجلوكوز بالدم زي ما احنا عارفين ومن
+
+411
+00:37:36,320 --> 00:37:39,360
+خلال اللي هو الـ glycolysis وإنتاج الطاقة، هيصير
+
+412
+00:37:39,360 --> 00:37:43,100
+في عندنا release لـReactive Oxygen Species
+
+413
+00:37:43,100 --> 00:37:46,140
+وبالتالي
+
+414
+00:37:46,140 --> 00:37:51,520
+يعني وجود الـC-Beptide كـAntioxidant ممكناللي هو
+
+415
+00:37:51,520 --> 00:37:58,620
+يقلل من الـ Reactive Oxygen Species اللي هتتكون
+
+416
+00:37:58,620 --> 00:38:03,440
+الانسولين
+
+417
+00:38:03,440 --> 00:38:06,300
+و الـ C-peptide secreted into the portal
+
+418
+00:38:06,300 --> 00:38:09,960
+circulation in equimolar amounts يبقى نفس الكمية
+
+419
+00:38:09,960 --> 00:38:13,540
+لأن زي ما شفنا أنه أنا الـ Proinsulin بيصير في
+
+420
+00:38:13,540 --> 00:38:19,640
+عندي a cleavage يبقى كل انسولين moleculeمقابله في
+
+421
+00:38:19,640 --> 00:38:25,000
+عندنا C-peptide يبقى في عندي نفس الكميات من
+
+422
+00:38:25,000 --> 00:38:28,520
+الانسولين اللي بيستخدعها الليز بالمقابل بيصير نفس
+
+423
+00:38:28,520 --> 00:38:34,600
+الكمية من ال C-peptide fasting C-peptide
+
+424
+00:38:34,600 --> 00:38:37,760
+concentration are five to ten fold higher than
+
+425
+00:38:37,760 --> 00:38:43,130
+those of insulinيبقى نفس الكمية بتدخل الدم لكن لما
+
+426
+00:38:43,130 --> 00:38:46,630
+نيجي نقيس كمية الـ C-peptide عند شخصين بنلاقي أنه
+
+427
+00:38:46,630 --> 00:38:52,710
+خمس إلى عشر أضعاف كمية الـ Insulin الموجودة والسبب
+
+428
+00:38:52,710 --> 00:38:57,630
+بيعود إلى الـ longer half-life لـ C-peptide اللي
+
+429
+00:38:57,630 --> 00:39:02,910
+تقريبا خمسة و تلاتين دقيقة مقارة بالـ half-life
+
+430
+00:39:02,910 --> 00:39:10,150
+للإنسلين اللي قلنا عبارة عن تقريبا خمس دقائقأيضًا
+
+431
+00:39:10,150 --> 00:39:15,090
+the liver does not extract C-peptide بيبصيرش كمان
+
+432
+00:39:15,090 --> 00:39:19,370
+extraction لأ لـ C-peptide مقارنة بإنسلين اللي
+
+433
+00:39:19,370 --> 00:39:23,010
+قلنا تقريبًا خمسين بالمية من الانسلين اللي بدخل ال
+
+434
+00:39:23,010 --> 00:39:28,490
+portal circulation بيصله extractionالـ C-peptide
+
+435
+00:39:28,490 --> 00:39:32,830
+بيصيرها الـ removal من ال circulation برضه عن طريق
+
+436
+00:39:32,830 --> 00:39:38,450
+الكدنى و بيصير فيه degradation في الكدنى و كمية
+
+437
+00:39:38,450 --> 00:39:46,070
+قليلة من ال intact C-peptide بتطلع في ال urine
+
+438
+00:39:46,070 --> 00:39:49,670
+يعني زي ما هي بدون اي degradation
+
diff --git a/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/bESKTB5yKZs.srt b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/bESKTB5yKZs.srt
new file mode 100644
index 0000000000000000000000000000000000000000..80111b0a20649fff0d6fe8a073dd5b508b8b3da5
--- /dev/null
+++ b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/bESKTB5yKZs.srt
@@ -0,0 +1,1514 @@
+
+1
+00:00:02,060 --> 00:00:05,600
+بسم الله الرحمن الرحيم والصلاة والسلام على خاتم
+
+2
+00:00:05,600 --> 00:00:09,280
+الأنبياء والمرسلين سيدنا محمد عليه الصلاة والسلام
+
+3
+00:00:09,280 --> 00:00:16,960
+يسعدني أن أكون معكم في مساق clinical
+
+4
+00:00:16,960 --> 00:00:23,120
+biochemistry أو كيمياء حيوية سريرية واللي إن شاء
+
+5
+00:00:23,120 --> 00:00:28,380
+الله سندرس من خلالها بعض الموضوعات التي تتعلق
+
+6
+00:00:28,380 --> 00:00:33,100
+بالكيمياء السريرية، يعني
+
+7
+00:00:33,100 --> 00:00:40,350
+تفاصيل أكثر، يعني more advanced مقارنة بالدراسة اللي
+
+8
+00:00:40,350 --> 00:00:45,610
+دراستوها في الـ baccalaureate. تم تنزيل الـ course
+
+9
+00:00:45,610 --> 00:00:51,970
+outline على صفحة الـ model. الموضوعات اللي سنتطرق
+
+10
+00:00:51,970 --> 00:00:58,470
+إليها إن شاء الله. من خلال دراستنا لهذا المساق سنبدأ
+
+11
+00:00:58,470 --> 00:01:04,410
+بالـ diabetes mellitus، وبعد هيك هيكون في عندنا الـ
+
+12
+00:01:04,410 --> 00:01:09,680
+cardiac function. طبعا زي ما قلنا، يعني هنحكي بتفصيل
+
+13
+00:01:09,680 --> 00:01:13,280
+أكثر، ليه
+
+14
+00:01:13,280 --> 00:01:17,680
+الأمراض المختلفة، ممكن اللي بتصيب الـ organs، كيف
+
+15
+00:01:17,680 --> 00:01:25,120
+ممكن تشخيصها، وهيكون دائما في نهاية المحاضرة في
+
+16
+00:01:25,120 --> 00:01:31,690
+بعض الـ case studies اللي سنتطرق إليها. عندنا أيضا الـ
+
+17
+00:01:31,690 --> 00:01:35,290
+kidney disease، في عندنا الـ disorders of water
+
+18
+00:01:35,290 --> 00:01:39,190
+electrolytes and acid base metabolism، liver
+
+19
+00:01:39,190 --> 00:01:43,370
+disease، gastric، pancreatic and intestinal
+
+20
+00:01:43,370 --> 00:01:48,800
+function، والـ bone and mineral metabolism. وإذا كان
+
+21
+00:01:48,800 --> 00:01:52,120
+ضال معانا وقت إن شاء الله هنشوف الـ evidence-based
+
+22
+00:01:52,120 --> 00:01:57,500
+laboratory medicine. هذه الموضوعات اللي هنتطرق إليها
+
+23
+00:01:57,500 --> 00:02:04,500
+إن شاء الله من خلال دراستنا للمادة، طبعا
+
+24
+00:02:04,500 --> 00:02:08,280
+اللي بالنسبة لنا توزيع الدرجات برضه موجود بالـ
+
+25
+00:02:08,280 --> 00:02:14,440
+course outline. في عامة للفصل خمسة وأربعين بالمئة،
+
+26
+00:02:15,250 --> 00:02:20,850
+عبارة عن ثلاثين بالمئة امتحان نصفي، وهيكون فيه
+
+27
+00:02:20,850 --> 00:02:26,790
+presentation هتقدموها، زي ما يعني حكيت التفاصيل على
+
+28
+00:02:26,790 --> 00:02:29,910
+مجموعة الـ whatsapp. هذا الـ presentation عليها خمس
+
+29
+00:02:29,910 --> 00:02:33,710
+عشر بالمئة، والامتحان النهائي هيكون إن شاء الله
+
+30
+00:02:33,710 --> 00:02:40,350
+عليه خمسة وخمسين بالمئة. الموضوع
+
+31
+00:02:40,350 --> 00:02:44,090
+الأول اللي هنبدأ فيه هو الـ diabetes mellitus.
+
+32
+00:02:47,990 --> 00:02:51,070
+الـ ده بيُسمى الـ Letus group of metabolic
+
+33
+00:02:51,070 --> 00:02:57,030
+disorders، يبقى مجموعة من الـ disorders، واللي
+
+34
+00:02:57,030 --> 00:03:06,130
+بتشترك بخاصية، وهي ارتفاع مستوى السكر في الدم، يبقى
+
+35
+00:03:06,130 --> 00:03:11,210
+في عندنا hyperglycemia، خاصية مشتركة بين هذه الـ
+
+36
+00:03:11,210 --> 00:03:17,080
+metabolic disorders. وهذا الارتفاع بـ glucose
+
+37
+00:03:17,080 --> 00:03:24,480
+ناتج عن سببَين. السبب الأول ممكن يكون بسبب الـ
+
+38
+00:03:24,480 --> 00:03:29,100
+defects in insulin secretion، يكون في عندي مشكلة في
+
+39
+00:03:29,100 --> 00:03:35,200
+الـ beta cells في الـ pancreas، اللي طبعا مسؤولة عن
+
+40
+00:03:35,200 --> 00:03:38,920
+إنتاج الـ insulin. يمكن يكون في عندي مشكلة في الـ
+
+41
+00:03:38,920 --> 00:03:42,040
+beta cells، وبالتالي في عندي مشكلة في الـ insulin
+
+42
+00:03:42,040 --> 00:03:47,260
+secretion. أو ممكن يكون في عندي مشكلة في الـ insulin
+
+43
+00:03:47,260 --> 00:03:53,140
+action. يبقى بيعمل الـ insulin، أو اللي هو الـ
+
+44
+00:03:53,140 --> 00:03:58,580
+sensitivity of cells for insulin. أو ممكن تكون
+
+45
+00:03:58,580 --> 00:04:04,540
+المشكلة بالـ insulin secretion والـ insulin action.
+
+46
+00:04:04,540 --> 00:04:10,000
+وهذا اللي بيصير بحالات اللي هي الحالات المتقدمة من
+
+47
+00:04:10,000 --> 00:04:12,040
+الـ type 2 diabetes mellitus.
+
+48
+00:04:15,370 --> 00:04:20,670
+المرضى اللي بيصابوا بـ diabetes mellitus، ممكن إذا
+
+49
+00:04:20,670 --> 00:04:25,670
+ارتفع مستوى السكر لمستويات أعلى من 600 milligram
+
+50
+00:04:25,670 --> 00:04:30,750
+per deciliter، ممكن يعني يتعرضوا لـ life threatening
+
+51
+00:04:30,750 --> 00:04:37,570
+conditions، يمكن يكون حياتهم يعني مهددة. في حال زي
+
+52
+00:04:37,570 --> 00:04:43,920
+ما اتفقنا أنه ارتفع مستوى الجلوكوز بشكل عالٍ. وهذا
+
+53
+00:04:43,920 --> 00:04:50,220
+طبعا مرتبط بالـ ketoacidosis زي ما هنشوف، وبالـ
+
+54
+00:04:50,220 --> 00:04:54,860
+hyperosmolar coma. يبقى إذا كان ارتفع مستوى
+
+55
+00:04:54,860 --> 00:04:57,560
+الجلوكوز عن 600 milligram per deciliter، طبعا ممكن
+
+56
+00:04:57,560 --> 00:05:03,100
+يرتفع لمستويات أعلى من هيك بكثير، يبقى فيه أن بعض
+
+57
+00:05:03,100 --> 00:05:06,280
+المرضى حسب نوع السكر اللي عندهم ممكن يتعرضوا لـ
+
+58
+00:05:06,280 --> 00:05:13,370
+ketoacidosis، اللي هي ممكن تصير فيه حموضة في الدم،
+
+59
+00:05:13,370 --> 00:05:17,630
+وانخفاض في الـ pH، أو ممكن تصير فيه hyperosmolar
+
+60
+00:05:17,630 --> 00:05:24,030
+coma، اللي هو السبب الأساسي بيكون الـ
+
+61
+00:05:24,030 --> 00:05:27,990
+dehydration اللي بيصير لهؤلاء المرضى.
+
+62
+00:05:31,740 --> 00:05:37,700
+أيضا من ناحية أخرى، ممكن يصير فيه انخفاض في مستوى
+
+63
+00:05:37,700 --> 00:05:40,860
+الـ glucose بالدم، وهذا برضه تعتبر life threatening
+
+64
+00:05:40,860 --> 00:05:46,480
+condition، بصير في عندنا hypoglycemia، برضه هذه
+
+65
+00:05:46,480 --> 00:05:52,540
+طبعا مشكلة لهؤلاء المرضى، وهذا ممكن طبعا يكون بسبب
+
+66
+00:05:52,540 --> 00:06:00,680
+العلاج، يعني يكون في جرعة مثلا زيادة من الـ insulin،
+
+67
+00:06:01,390 --> 00:06:04,750
+أو يكون المريض أخذ الجرعة المناسبة لكن يكون بذل
+
+68
+00:06:04,750 --> 00:06:08,350
+مجهود أكبر، على سبيل المثال، جهد زايد، ده ممكن يؤدي إلى
+
+69
+00:06:08,350 --> 00:06:14,410
+hypoglycemia، واللي برضه طبعا أكيد يعتبر يعني مهدد
+
+70
+00:06:14,410 --> 00:06:19,710
+للحياة. As
+
+71
+00:06:19,710 --> 00:06:23,070
+the disease progresses, patients are at increased
+
+72
+00:06:23,070 --> 00:06:26,050
+risk for the development of specific complications.
+
+73
+00:06:26,870 --> 00:06:32,850
+بكمان ارتفاع الجلوكوز المستمر في الدم، هذا هيؤدي
+
+74
+00:06:32,850 --> 00:06:37,230
+إلى العديد من المشاكل للمرضى، العديد من الـ
+
+75
+00:06:37,230 --> 00:06:41,950
+complications، وهذه الـ complications ممكن تكون
+
+76
+00:06:41,950 --> 00:06:48,380
+microvascular، وممكن تكون macrovascular. الـ
+
+77
+00:06:48,380 --> 00:06:52,420
+microvascular complications، يعني عندنا أمثلة عديدة،
+
+78
+00:06:52,420 --> 00:06:57,640
+زي اللي هو الـ retinopathy، تصير في عندنا مشكلة في
+
+79
+00:06:57,640 --> 00:07:03,700
+الشبكية، واللي ممكن تؤدي إلى العمى. أيضا ممكن تصير
+
+80
+00:07:03,700 --> 00:07:09,300
+في عندنا مشكلة بالـ microvessels في الـ kidney، واللي
+
+81
+00:07:09,300 --> 00:07:12,820
+ممكن تؤدي إلى nephropathy، وممكن ينتهي المريض بـ
+
+82
+00:07:12,820 --> 00:07:19,590
+renal failure. وعندنا يعني عدد ليس بسيطا من الـ ...
+
+83
+00:07:19,590 --> 00:07:27,700
+المرضى اللي عندهم renal failure هم مرضى سكري. أيضا
+
+84
+00:07:27,700 --> 00:07:32,560
+الـ neuropathy، برضه ممكن تصير في عندنا مشكلة في الـ
+
+85
+00:07:32,560 --> 00:07:36,780
+... على مستوى الأعصاب، واللي ممكن تؤدي إلى nerve
+
+86
+00:07:36,780 --> 00:07:40,660
+damage. يعني الـ complications اللي مرتبطة بارتفاع
+
+87
+00:07:40,660 --> 00:07:44,020
+مستوى الجلوكوز في الدم عديدة، زي ما قلنا،
+
+88
+00:07:44,020 --> 00:07:47,300
+microvascular، وفي عندنا الـ macrovascular.
+
+89
+00:07:48,790 --> 00:07:53,890
+اللي هو في الـ atherosclerosis، تصلب الشرايين، و
+
+90
+00:07:53,890 --> 00:07:58,610
+طبعا اللي الـ atherosclerosis بتؤدي إلى ضيق في
+
+91
+00:07:58,610 --> 00:08:03,170
+الأوعية الدموية في الشرايين، واللي ممكن ينتهي
+
+92
+00:08:03,170 --> 00:08:08,470
+الأمر بانسداد كامل للشريان، وبالتالي المنطقة اللي
+
+93
+00:08:08,470 --> 00:08:14,270
+بيغذيها هذا الشريان هتنحرم من الـ oxygen، وطبعا
+
+94
+00:08:14,270 --> 00:08:23,470
+ممكن يعني يصير فينا موت لهذا الجزء. يبقى الـ
+
+95
+00:08:23,470 --> 00:08:27,450
+atherosclerosis حسب المشكلة في أي شريان موجود، ممكن
+
+96
+00:08:27,450 --> 00:08:31,650
+هذا يؤدي إلى stroke، إذا كان عندنا الـ
+
+97
+00:08:31,650 --> 00:08:37,350
+atherosclerosis في الـ arteries اللي بتغذي المخ.
+
+98
+00:08:37,350 --> 00:08:41,590
+فيانا، ممكن إذا كان صار في atherosclerosis بالشريان
+
+99
+00:08:41,590 --> 00:08:45,710
+اللي بتغذي الأطراف، وصار في عندنا انسداد كامل، هذا
+
+100
+00:08:45,710 --> 00:08:52,690
+ممكن يؤدي إلى gangrene. وإذا كان عندنا الشريان اللي
+
+101
+00:08:52,690 --> 00:08:56,750
+فيه المشكلة هو اللي بيغذي عضلة القلب، تمام؟ في حالة
+
+102
+00:08:56,750 --> 00:08:59,710
+اللي بقول إن الـ artery disease بيحدث، ممكن يؤدي إلى
+
+103
+00:08:59,710 --> 00:09:04,610
+يعني موت جزء من عضلة القلب، طبعا حسب اللي هو
+
+104
+00:09:04,610 --> 00:09:09,530
+الشريان اللي صار فيه عندنا اللي هو انسداد كامل.
+
+105
+00:09:09,530 --> 00:09:13,750
+يبقى الـ complications عديدة وأيضا خطيرة.
+
+106
+00:09:18,750 --> 00:09:23,710
+طبعا مشكلة الـ ... الـ ... السكري، أو مرض السكري يعني
+
+107
+00:09:23,710 --> 00:09:30,110
+مشكلة كبيرة، والمشكلة كل ما لها أيضا بزيادة، و
+
+108
+00:09:30,110 --> 00:09:36,570
+أعداد الناس اللي بتصاب بمرض السكري بتزيد بشكل غير
+
+109
+00:09:36,570 --> 00:09:43,090
+اللي هو أو أعلى من المتوقع، دائما. Number of people
+
+110
+00:09:43,090 --> 00:09:46,050
+with diabetes has increased dramatically worldwide.
+
+111
+00:09:47,910 --> 00:09:55,930
+عندنا بـ 2013 كان عدد المرضى 382 مليون، ومتوقع
+
+112
+00:09:55,930 --> 00:10:03,990
+أنه يزيد العدد إلى 592 مليون، هذا في العام 2035. يبقى
+
+113
+00:10:03,990 --> 00:10:09,250
+العدد كان بـ 2013 382 مليون، وبناء على الحسابات
+
+114
+00:10:09,250 --> 00:10:14,410
+اللي عملوها، توقعوا أنه بـ 2035 يصير 592
+
+115
+00:10:14,410 --> 00:10:29,240
+مليون. في 2019 العدد وصل إلى 463 مليون، 463 مليون، يبقى
+
+116
+00:10:29,240 --> 00:10:34,140
+بـ 2035 أكيد العدد هيكون أكبر بكثير من التوقع
+
+117
+00:10:34,140 --> 00:10:41,950
+في العام 2013. ويعني صار التوقع، بناء على
+
+118
+00:10:41,950 --> 00:10:49,230
+عدد المرضى في عام 2019، صار التوقع أنه بـ 2040
+
+119
+00:10:49,230 --> 00:10:55,190
+يصل العدد إلى 700 مليون مريض بالسكري.
+
+120
+00:11:01,180 --> 00:11:04,260
+This number is predicted to reach 592، زي ما قلنا،
+
+121
+00:11:04,260 --> 00:11:07,500
+في العام 2035. Eighty percent of
+
+122
+00:11:07,500 --> 00:11:11,220
+whom will live in low and middle income countries.
+
+123
+00:11:11,220 --> 00:11:15,860
+يعني العدد الأكبر من المرضى هيكونوا موجودين في
+
+124
+00:11:15,860 --> 00:11:22,640
+اللي هي البلاد اللي مستوى الدخل فيها يعني منخفض أو
+
+125
+00:11:22,640 --> 00:11:29,720
+متوسط. هذا الشكل بيوضح اللي هو توزيع الأعداد اللي ...
+
+126
+00:11:29,720 --> 00:11:34,500
+اللي هي الـ 382 اللي حكينا كانت بالـ 2013، على اللي
+
+127
+00:11:34,500 --> 00:11:38,800
+هي المناطق المختلفة، أو القارات المختلفة، ليه اللي
+
+128
+00:11:38,800 --> 00:11:43,840
+هو العالم. وهو عندنا يعني مبين اللي ... اللي هو
+
+129
+00:11:43,840 --> 00:11:51,480
+عندنا الصين اللي هو أعلى عدد من المرضى، تقريبا
+
+130
+00:11:51,480 --> 00:11:53,580
+ثلاثة وثمانين مليون.
+
+131
+00:11:55,680 --> 00:12:02,460
+المشكلة أيضا إنه في عندنا نسبة من الناس مصابة
+
+132
+00:12:02,460 --> 00:12:08,760
+بمرض السكري لكن undiagnosed، والمشكلة إنه هذا العدد
+
+133
+00:12:08,760 --> 00:12:14,620
+ليس بسيطا، يعني إحنا لما بنحكي على 382 مليون شخص، هدول
+
+134
+00:12:14,620 --> 00:12:19,210
+تم تشخيصهم إنهم مصابين بالـ diabetes mellitus.
+
+135
+00:12:19,210 --> 00:12:27,530
+بالمقابل في عندنا 175 مليون، هدول undiagnosed، يبقى
+
+136
+00:12:27,530 --> 00:12:35,590
+دائما العدد فعليا للناس المصابة هو أكبر من الأرقام
+
+137
+00:12:35,590 --> 00:12:36,830
+المعلنة.
+
+138
+00:12:38,600 --> 00:12:43,820
+ويعني هذه برضه مشكلة، أنه ما يتم اكتشاف المرض بشكل
+
+139
+00:12:43,820 --> 00:12:50,300
+سريع. وعادة يعني مرضى السكري ممكن يتم الـ diagnosis
+
+140
+00:12:50,300 --> 00:12:56,820
+لهم، ويكون فعليا بدأت عندنا الـ complications بالظهور.
+
+141
+00:12:56,820 --> 00:13:00,640
+يبقى بيكون عندنا الـ diagnosis صارت متأخرة بشكل
+
+142
+00:13:00,640 --> 00:13:01,700
+كبير.
+
+143
+00:13:06,200 --> 00:13:09,480
+Acute and chronic complications make diabetes the
+
+144
+00:13:09,480 --> 00:13:12,700
+fourth most common cause of death in the developed
+
+145
+00:13:12,700 --> 00:13:16,060
+world. يبقى الـ complications العديدة اللي حكينا
+
+146
+00:13:16,060 --> 00:13:21,160
+عليها، اللي هو سواء الـ ... الارتفاع اللي ... اللي هو
+
+147
+00:13:21,160 --> 00:13:23,840
+مستوى الـ glucose، والـ life threatening conditions،
+
+148
+00:13:23,840 --> 00:13:27,660
+اللي ممكن اللي هو تصير مع الـ complications، اللي هي
+
+149
+00:13:28,020 --> 00:13:31,860
+على مستوى الـ microvessels أو الـ macrovessels، هذه
+
+150
+00:13:31,860 --> 00:13:40,600
+بتؤدي إلى يعني موت مرضى السكري، ويعتبر يعني الموت
+
+151
+00:13:40,600 --> 00:13:48,540
+من هذا المرض، رابع سبب للموت in the developed world.
+
+152
+00:13:53,890 --> 00:14:01,310
+Diabetes caused 5.1 million deaths in 2013. وهذا
+
+153
+00:14:01,310 --> 00:14:08,750
+اللي هو بيمثل يعني أن الشخص بيموت كل ست ثواني بسبب
+
+154
+00:14:08,750 --> 00:14:10,110
+مرض السكري.
+
+155
+00:14:13,910 --> 00:14:18,910
+الـ ... أيضا الـ ... مرض السكري، والرعاية اللي
+
+156
+00:14:18,910 --> 00:14:28,030
+بتقدمها الدول للمرضى برضه تكلفتها عالية جدا، تكلفة
+
+157
+00:14:28,030 --> 00:14:34,900
+اللي هو المتابعة للمرضى، تكلفة العلاج، تكلفة اللي هي
+
+158
+00:14:34,900 --> 00:14:40,240
+الـ complications، ودخول المستشفيات، هذه الأسباب
+
+159
+00:14:40,240 --> 00:14:48,760
+المختلفة. يبقى هذه التكلفة عالية، والتكلفة بـ 2013
+
+160
+00:14:48,760 --> 00:14:56,800
+كانت 548 billion دولار، يبقى
+
+161
+00:14:59,050 --> 00:15:06,710
+548 مليار دولار هذه التكلفة، ومتوقع أن التكلفة
+
+162
+00:15:06,710 --> 00:15:15,070
+تزيد في العام 2035 إلى 627 مليار
+
+163
+00:15:15,070 --> 00:15:22,090
+دولار. ولكن فعليا حسب الإحصائيات اللي عملوها بـ
+
+164
+00:15:22,090 --> 00:15:30,380
+2019، التكلفة على هذا اللي هو القطاع وصلت 760
+
+165
+00:15:30,380 --> 00:15:37,590
+مليار دولار. زي ما قلنا إنه دائما الأعداد يعني
+
+166
+00:15:37,590 --> 00:15:42,810
+بتفوق المتوقع، وبالتالي أيضا اللي هو التكلفة،
+
+167
+00:15:42,810 --> 00:15:46,130
+وتكلفة تقديم الخدمة الصحية لهذه اللي هو الفئة من
+
+168
+00:15:46,130 --> 00:15:50,550
+المرضى برضه بتفوق المتوقع، يعني كان وصلت، كان متوقع
+
+169
+00:15:50,550 --> 00:15:58,850
+أنه بـ 2030 تصل 627 مليار، بـ 2019 وصلت 760 مليار.
+
+170
+00:16:02,900 --> 00:16:05,260
+طيب، بالنسبة لها الـ classification of diabetes
+
+171
+00:16:05,260 --> 00:16:10,900
+mellitus، ممكن نقسم الـ diabetes mellitus إلى أربعة
+
+172
+00:16:10,900 --> 00:16:15,680
+أقسام أساسية. في عندنا الـ type 1 diabetes، وممكن
+
+173
+00:16:15,680 --> 00:16:19,840
+نقسمه إلى قسمين، الـ immune mediated والـ idiopathic.
+
+174
+00:16:19,840 --> 00:16:22,560
+في عندنا الـ type 2 diabetes، في عندنا الـ other
+
+175
+00:16:22,560 --> 00:16:26,800
+specific types، وعندنا
+
+176
+00:16:26,800 --> 00:16:33,010
+الـ gestational diabetes mellitus. هنحكي شوية بتفصيل
+
+177
+00:16:33,010 --> 00:16:39,570
+عن هذه الأنواع المختلفة، ونبدأ بالـ type 1 diabetes.
+
+178
+00:16:39,570 --> 00:16:43
+
+223
+00:20:24,730 --> 00:20:29,810
+الأكبر للناس اللي بيصابوا، اللي بيكونوا أطفال
+
+224
+00:20:29,810 --> 00:20:33,870
+تقريبا 75% acquired the disease before the age of
+
+225
+00:20:33,870 --> 00:20:38,730
+18, but onset in the remainder may occur at any
+
+226
+00:20:38,730 --> 00:20:39,350
+age
+
+227
+00:20:43,770 --> 00:20:47,150
+النوع الثاني اللي عندنا هو الـ type 2 diabetes
+
+228
+00:20:47,150 --> 00:20:51,190
+mellitus، طبعا ده بيمثل النسبة الأكبر من الـ
+
+229
+00:20:51,190 --> 00:20:56,230
+diabetes mellitus، اللي هو أكثر من 90% of all cases
+
+230
+00:20:56,230 --> 00:21:01,350
+of diabetes patients have minimal symptoms, are not
+
+231
+00:21:01,350 --> 00:21:09,370
+prone to ketosis. طبعا موضوع الـ ketosis مرتبط بوجود
+
+232
+00:21:09,370 --> 00:21:16,190
+الـ insulin أو عدم وجود الـ insulin. حكينا بيه الـ
+
+233
+00:21:16,190 --> 00:21:21,090
+Type 1، إنه مرضى الـ Type 1 بيتمدوا على الانسولين
+
+234
+00:21:21,090 --> 00:21:27,030
+to sustain life، وده  عشان نمنع الـ Ketosis لأن
+
+235
+00:21:27,030 --> 00:21:36,870
+عدم وجود الانسولين هذا يؤدي إلى زيادة بشكل كبير في
+
+236
+00:21:36,870 --> 00:21:38,590
+هرمون الـ glucagon
+
+237
+00:21:41,150 --> 00:21:44,270
+يبقى بيزيد عندنا الجلوكاجون، وبالتالي الجلوكاجون
+
+238
+00:21:44,270 --> 00:21:49,510
+بيزيد من الـ glycogenolysis وبيزيد أيضا من
+
+239
+00:21:49,510 --> 00:21:54,950
+الجلوكونيوجينيسيس، نعم يبقى بيزيد من الجلوكونيوجينيسيس
+
+240
+00:21:54,950 --> 00:21:58,790
+وبالتالي بيزيد من اللي هو تصنيع الـ carbohydrates
+
+241
+00:21:58,790 --> 00:22:03,570
+from non-carbohydrate sources زي الـ lipids وهذا
+
+242
+00:22:03,570 --> 00:22:10,000
+بيؤدي إلى إنتاج كميات كبيرة من الـ ketone bodies، و
+
+243
+00:22:10,000 --> 00:22:14,900
+الـ ketone bodies اللي هو acidic و بيعملوا على خفض
+
+244
+00:22:14,900 --> 00:22:22,400
+الـ pH للدم. لكن
+
+245
+00:22:22,400 --> 00:22:29,050
+بالـ type 2، الـ insulin موجود، طبعا يبقى ما زال الـ
+
+246
+00:22:29,050 --> 00:22:33,930
+insulin موجود، يبقى الـ insulin بيعمل inhibition على
+
+247
+00:22:33,930 --> 00:22:38,930
+الـ alpha cells، وبالتالي بيقلل أو بيمنع من إفراز
+
+248
+00:22:38,930 --> 00:22:44,450
+الـ glucagon، عشان
+
+249
+00:22:44,450 --> 00:22:47,390
+هيك بنقول إن الـ patients have minimal symptoms، و
+
+250
+00:22:47,390 --> 00:22:51,950
+are not prone to ketosis. ليش؟ they are not prone to
+
+251
+00:22:51,950 --> 00:22:54,810
+ketosis لأن الـ insulin موجود
+
+252
+00:22:56,880 --> 00:23:01,680
+are not dependent on insulin to prevent ketonuria.
+
+253
+00:23:01,680 --> 00:23:07,720
+يبقى بيعتمدوش على اللي هو الـ insulin زي ما قلنا
+
+254
+00:23:07,720 --> 00:23:11,380
+لمنع اللي هو طبعا إنتاج الـ ketone bodies اللي ممكن
+
+255
+00:23:11,380 --> 00:23:14,700
+تظهر بعد هيك، طبعا في يعني تكون موجودة في الدم
+
+256
+00:23:14,700 --> 00:23:20,950
+وأيضا بتبدأ تظهر في الـ urine لأنهم they are notاللي
+
+257
+00:23:20,950 --> 00:23:24,110
+هو insulin dependent. وعشان هيك كانوا زمان الـ type 2
+
+258
+00:23:24,110 --> 00:23:28,330
+diabetes يسمى non-insulin dependent، لكن طبعا تم
+
+259
+00:23:28,330 --> 00:23:32,150
+تغيير هذا الاسم، لأنه لاقوا إنه المرضى من النوع
+
+260
+00:23:32,150 --> 00:23:37,570
+الثاني ممكن في الحالات المتقدمة ممكن يصيروا
+
+261
+00:23:37,570 --> 00:23:43,200
+يعتمدوا على الـ insulin. يبقى في مراحل متقدمة من
+
+262
+00:23:43,200 --> 00:23:48,240
+المرض ممكن يبدأ الـ type 2 diabetes mellitus patient
+
+263
+00:23:48,240 --> 00:23:53,640
+ممكن يبدأ ياخد insulin. insulin
+
+264
+00:23:53,640 --> 00:23:57,500
+concentrations may be normal, decreased, or
+
+265
+00:23:57,500 --> 00:24:00,960
+increased, and most people with this form of
+
+266
+00:24:00,960 --> 00:24:06,220
+diabetes have impaired insulin action. يبقى لو
+
+267
+00:24:06,220 --> 00:24:10,390
+أجينا فحصنا مستويات الـ insulin ممكن نلاقي إنه
+
+268
+00:24:10,390 --> 00:24:17,510
+المستويات طبيعية، أو نلاقي إنه المستويات أقل من
+
+269
+00:24:17,510 --> 00:24:25,810
+الطبيعي، أو أكثر من الطبيعي، طبعا في البداية يعني بس
+
+270
+00:24:25,810 --> 00:24:31,350
+بتبدأ ترتفع، لأنه مستويات الجلوكوز، الـ pancreas أكيد
+
+271
+00:24:31,350 --> 00:24:37,920
+بيبدأ يزيد من إنتاجه للانسولين، لأن ده بيعمل الـ
+
+272
+00:24:37,920 --> 00:24:42,560
+compensation، لأن الـ glucose زاد، يبقى الـ الـ
+
+273
+00:24:42,560 --> 00:24:47,400
+pancreas بده يفرز أكثر insulin عشان يحافظ على
+
+274
+00:24:47,400 --> 00:24:52,940
+مستوى الـ glucose ضمن الـ reference interval، يعني
+
+275
+00:24:52,940 --> 00:24:56,700
+ممكن في البدايات تلاقي إنه الـ .. الـ Glucose
+
+276
+00:24:56,700 --> 00:25:02,360
+الانسولين، الـ concentration ممكن تبدأ ترتفع، لكن مع
+
+277
+00:25:02,360 --> 00:25:06,200
+الاستمرار في الارتفاع لمستوى الـ Glucose، ممكن يبدأ
+
+278
+00:25:06,200 --> 00:25:11,160
+يصير في عندنا اللي هو يعني إنهاك للبنكرياس
+
+279
+00:25:11,160 --> 00:25:17,100
+وبالتالي ممكن تبدأ بعد هيك، فيه مستويات الـ insulin
+
+280
+00:25:17,100 --> 00:25:23,000
+تبدأ بالانخفاض، وزي ما قلنا اللي هو في يعني مراحل
+
+281
+00:25:23,000 --> 00:25:28,780
+متقدمة ممكن يبدأ المريض الـ type 2 اللي هو يعتمد
+
+282
+00:25:28,780 --> 00:25:32,040
+على اللي هو الـ insulin الخارجي
+
+283
+00:25:36,520 --> 00:25:39,520
+طبعاً هذا، لأنه زي ما قلنا إنه فيه impaired insulin
+
+284
+00:25:39,520 --> 00:25:43,760
+action، في عندنا هنا مشكلة في عمل الـ insulin، في
+
+285
+00:25:43,760 --> 00:25:47,160
+عندنا الـ sensitivity of cells to insulin، اللي هو
+
+286
+00:25:47,160 --> 00:25:54,920
+أقل من الطبيعي، وبالتالي بتحتاج إلى concentrations
+
+287
+00:25:54,920 --> 00:26:03,320
+أعلى من الـ insulin عشان تقوم بالوظيفة المطلوبة. الـ
+
+288
+00:26:03,320 --> 00:26:10,310
+obesity بتلعب دور في الـ type 2 diabetes mellitus
+
+289
+00:26:10,310 --> 00:26:16,390
+obesity is commonly associated. الـ الـ الـ obesity، و
+
+290
+00:26:16,390 --> 00:26:19,030
+أيضا الـ يعني في بعض الأشخاص اللي بيكونوا
+
+291
+00:26:19,030 --> 00:26:26,280
+overweight، يبقى obese أو ممكن overweight، وعشان هيك
+
+292
+00:26:26,280 --> 00:26:29,520
+الـ weight loss alone usually improves
+
+293
+00:26:29,520 --> 00:26:34,000
+hyperglycemia. يعني عادة اللي هو مرضى السكري
+
+294
+00:26:34,000 --> 00:26:38,900
+النصيحة الأولى اللي بوجهها لهم الطبيب، إنه لازم
+
+295
+00:26:38,900 --> 00:26:46,260
+ينزلوا وزنهم، لو نزلوا وزنهم هذا ممكن يحسن من
+
+296
+00:26:46,260 --> 00:26:53,880
+مستويات الـ glucose عندهم. والناس اللي لسه في مرحلة
+
+297
+00:26:53,880 --> 00:26:58,960
+الـ Prediabetes، لو نزلوا وزنهم، لعبوا رياضة، غيروا
+
+298
+00:26:58,960 --> 00:27:04,200
+نمط حياتهم، ممكن يعني يمنعوا بشكل كبير الإصابة
+
+299
+00:27:04,200 --> 00:27:09,660
+بالـ Type 2. However,
+
+300
+00:27:09,700 --> 00:27:12,700
+many individuals with Type 2 diabetes mellitus may
+
+301
+00:27:12,700 --> 00:27:16,220
+require dietary intervention, oral anti-
+
+302
+00:27:16,220 --> 00:27:20,090
+hyperglycemic agents, or insulin to control
+
+303
+00:27:20,090 --> 00:27:25,630
+hyperglycemia. طبعا
+
+304
+00:27:25,630 --> 00:27:30,570
+أول شغلة بيبدأ فيها الطبيب في حالة الـ diagnosis
+
+305
+00:27:30,570 --> 00:27:34,590
+لشخص بـ type 2 diabetes mellitus هو الـ dietary
+
+306
+00:27:34,590 --> 00:27:42,230
+intervention. يبقى لفترة، إذا اتحسن مستوى الـ glucose
+
+307
+00:27:42,230 --> 00:27:45,730
+ممكن اللي هو يستمرّوا ب اللي هو الـ diet أو الـ
+
+308
+00:27:45,730 --> 00:27:49,470
+dietary intervention. لكن لو دال الـ .. الـ .. الـ
+
+309
+00:27:49,470 --> 00:27:53,910
+glucose مرتفع، بيبدأ لو بيعطي الأدوية اللي هي الـ
+
+310
+00:27:53,910 --> 00:27:58,610
+oral anti-hyperglycemic agents، وزي ما قلنا في
+
+311
+00:27:58,610 --> 00:28:05,570
+مراحل متقدمة من المرض ممكن الطبيب يلجأ إلى الـ
+
+312
+00:28:05,570 --> 00:28:09,470
+insulin. Most
+
+313
+00:28:09,470 --> 00:28:12,750
+patients acquired the disease after age 40, but it may
+
+314
+00:28:12,750 --> 00:28:20,630
+occur in younger people. يبقى زمان كان الـ .. يعني
+
+315
+00:28:20,630 --> 00:28:26,890
+الناس اللي بيصابوا عادة بيكونوا فوق الأربعين، لكن
+
+316
+00:28:26,890 --> 00:28:33,370
+الآن صار في أطفال بيصابوا ب الـ type 2 diabetes
+
+317
+00:28:33,370 --> 00:28:39,190
+mellitus. طبعا هذا بيرجع لـ اللي هو نوع الطعام اللي
+
+318
+00:28:39,190 --> 00:28:45,480
+بنتناوله، اللي هو الطعام الغير صحي، نمط الحياة اللي
+
+319
+00:28:45,480 --> 00:28:52,440
+بنعيشه، اللي هو كله يعني خمول، وما فيه حركة، وما فيه رياضة
+
+320
+00:28:52,440 --> 00:28:59,300
+تمام، وبالتالي هذا يعني أدى إلى انخفاض في العمر
+
+321
+00:28:59,300 --> 00:29:03,300
+اللي هو حدوث هذا المرض.
+
+322
+00:29:05,680 --> 00:29:08,620
+Type 2 diabetes mellitus في الأولاد والأطفال هو
+
+323
+00:29:08,620 --> 00:29:16,500
+مشكلة مهمة، كثيرة، زي ما قلنا، هذا يعني مرتبط بالطعام
+
+324
+00:29:16,500 --> 00:29:25,000
+والحياة اللي بنعيشها حاليا. among children in Japan
+
+325
+00:29:25,000 --> 00:29:28,480
+in 1998, Type 2 diabetes mellitus was more common
+
+326
+00:29:28,480 --> 00:29:33,340
+than Type 1, accounting for 80% of childhood
+
+327
+00:29:33,340 --> 00:29:40,110
+diabetes. طبعا يبقى في الـ 98 في اليابان كان نسبة
+
+328
+00:29:40,110 --> 00:29:47,330
+عالية من الأطفال مصابين بالـ type 2 diabetes، وأكثر
+
+329
+00:29:47,330 --> 00:29:51,370
+طبعا من الأطفال اللي مصابين بيه اللي هو الـ type 1
+
+330
+00:29:51,370 --> 00:29:54,330
+نحنا بنقول إن اللي هو الـ type 1 عادة هو juvenile
+
+331
+00:29:54,330 --> 00:29:59,390
+لكن بسبب اللي هو زي ما قلنا الطعام، والحياة اللي
+
+332
+00:29:59,390 --> 00:30:05,530
+بعيشها هؤولاء الأطفال، صار في إصابات عالية عندهم بالـ
+
+333
+00:30:05,530 --> 00:30:09,790
+Type 2. الـ
+
+334
+00:30:09,790 --> 00:30:13,510
+class الثالث: specific types of diabetes mellitus
+
+335
+00:30:13,510 --> 00:30:18,750
+due to other causes. هنا عندنا الـ diabetes
+
+336
+00:30:18,750 --> 00:30:24,050
+mellitus أو الـ hyperglycemia هي secondary لـ
+
+337
+00:30:24,050 --> 00:30:30,650
+primary disease. ما في عندنا مشكلة أساسية، ونتيجة هذه
+
+338
+00:30:30,650 --> 00:30:35,810
+المشكلة صار في عندنا ارتفاع في الجلوكوز. this
+
+339
+00:30:35,810 --> 00:30:38,610
+subclass includes uncommon patients in whom
+
+340
+00:30:38,610 --> 00:30:41,710
+hyperglycemia is due to a specific underlying
+
+341
+00:30:41,710 --> 00:30:46,330
+disorder. إذا ما قلنا له secondary لـ disorder أو
+
+342
+00:30:46,330 --> 00:30:54,570
+مشكلة موجودة. وعندنا من الأسباب الـ genetic defects
+
+343
+00:30:54,570 --> 00:30:59,730
+of beta cell function. واللي هو هذا النوع اللي بيطلق
+
+344
+00:30:59,730 --> 00:31:05,650
+عليه maturity onset diabetes of the young. يعني في
+
+345
+00:31:05,650 --> 00:31:11,710
+عندنا مشكلة بالـ beta cell function، وبالتالي بيكون
+
+346
+00:31:11,710 --> 00:31:20,410
+في عندنا انخفاض في مستوى الـ insulin. genetic
+
+347
+00:31:20,410 --> 00:31:24,850
+defects in insulin action. ممكن يكون في عندنا
+
+348
+00:31:24,850 --> 00:31:28,550
+genetic defect في نفس الانسولين. type A insulin
+
+349
+00:31:28,550 --> 00:31:31,930
+resistance syndrome due to insulin receptor gene
+
+350
+00:31:31,930 --> 00:31:39,190
+mutations. المشكلة في الـ receptor أو mutation في الـ
+
+351
+00:31:39,190 --> 00:31:43,450
+الـ اللي هو الـ insulin receptor gene
+
+352
+00:31:46,790 --> 00:31:51,490
+برضه عندنا الأمراض اللي بتصيب الـ pancreas، برضه هذه
+
+353
+00:31:51,490 --> 00:31:58,170
+ممكن تؤدي إلى يعني انخفاض في الـ release of insulin
+
+354
+00:31:58,170 --> 00:32:04,770
+زي الـ cystic fibrosis. اه زي ما أنتو عارفين اللي هو
+
+355
+00:32:04,770 --> 00:32:09,150
+الـ .. هذا بيعمل viscous and mucous، وبالتالي يعني
+
+356
+00:32:09,150 --> 00:32:15,710
+بيمنع من الـ .. أو بيأثر يعني على وظيفة الـ pancreas
+
+357
+00:32:15,710 --> 00:32:20,190
+بشكل عام، وبالتالي بيقلل من الـ release of insulin
+
+358
+00:32:20,190 --> 00:32:26,500
+أيضا في عندنا الـ endocrinopathies، المشكلات اللي متعلقة
+
+359
+00:32:26,500 --> 00:32:30,900
+بالأُصول الهرمونات، زي في عندنا اللي هو الـ
+
+360
+00:32:30,900 --> 00:32:35,160
+Cushing's Syndrome، وهذا طبعا اللي بيؤدي إلى
+
+361
+00:32:35,160 --> 00:32:39,180
+ارتفاع في الكورتزول، وزي ما أنتو عارفين الكورتزول
+
+362
+00:32:39,180 --> 00:32:45,800
+هو عبارة عن hyperglycemic agent، بيعمل على رفع هرمون
+
+363
+00:32:45,800 --> 00:32:50,960
+اللي هو بيزيد من مستويات الجلوكوز في الدم. الـ
+
+364
+00:32:50,960 --> 00:32:57,070
+Acromegaly، ويكون في عندنا زيادة في الـ Growth
+
+365
+00:32:57,070 --> 00:32:58,910
+hormone، والـ Growth hormone برضه بيعتبر
+
+366
+00:32:58,910 --> 00:33:05,820
+hyperglycemic agent. والـ glucagonoma اللي هو عندنا
+
+367
+00:33:05,820 --> 00:33:10,900
+form of pancreatic cancer، اللي بيصير فيه عندنا
+
+368
+00:33:10,900 --> 00:33:17,120
+إنتاج لكميات كبيرة من الـ glucagon، وبرضه زي ما
+
+369
+00:33:17,120 --> 00:33:21,620
+أنتم عارفين الـ glucagon هو عبارة عن hyperglycemic
+
+370
+00:33:21,620 --> 00:33:26,880
+agents، من الهرمونات اللي بترفع مستويات الـ glucose
+
+371
+00:33:26,880 --> 00:33:33,550
+في الدم. إن أيضا إعطاء المرضى بعض الـ .. الهرمونات
+
+372
+00:33:33,550 --> 00:33:40,370
+أو ممكن بعض الأدوية، هذا ممكن يأثر على الـ beta
+
+373
+00:33:40,370 --> 00:33:42,750
+cell function، اللي هو على سبيل المثال، أو ممكن
+
+374
+00:33:42,750 --> 00:33:48,070
+يعمل impairment لانسولين action. وهنا في عندنا
+
+375
+00:33:48,070 --> 00:33:52,910
+أمثلة على أدوية اللي بتعمل Beta cell dysfunction
+
+376
+00:33:52,910 --> 00:33:57,110
+زي الـ Dilantin، اللي هو عبارة عن antiepileptic
+
+377
+00:33:57,110 --> 00:34:01,110
+drug، اللي هو علاج بيُعطى للناس اللي عندهم اللي هو
+
+378
+00:34:01,110 --> 00:34:06,950
+تشنجات أو صرع. وفي عندنا الـ pentamidine، antifungal
+
+379
+00:34:06,950 --> 00:34:12,370
+drug. يبقى بعض الأدوية بتأثر على الـ Beta cell
+
+380
+00:34:12,370 --> 00:34:17,500
+function، وبالتالي بتقلل من الـ release of insulin
+
+381
+00:34:17,500 --> 00:34:23,220
+أدوية أخرى impair insulin action، بتأثر على عمل الـ
+
+382
+00:34:23,220 --> 00:34:26,160
+insulin، زي الـ glucocorticoids
+
+383
+00:34:28,990 --> 00:34:33,830
+والـ الكورتزول، زي أن الفازايد، لأدوية عبارة عن
+
+384
+00:34:33,830 --> 00:34:36,790
+diuretics، اللي هي الأدوية المدرة للبول اللي بتعطى
+
+385
+00:34:36,790 --> 00:34:42,570
+للأشخاص اللي عندهم hypertension، ارتفاع في ضغط الدم
+
+386
+00:34:42,570 --> 00:34:49,130
+و أيضا الـ beta-adrenergics
+
+387
+00:34:50,880 --> 00:34:56,220
+اللي بتعطى لمرضى اللي عندهم ضيق في التنفس أو
+
+388
+00:34:56,220 --> 00:35:02,280
+الربو. يبقى أدوية مختلفة ممكن تأثر سواء على الـ beta
+
+389
+00:35:02,280 --> 00:35:07,380
+cell function، أو تعمل impairment للـ insulin action
+
+390
+00:35:07,380 --> 00:35:13,680
+أيضا الـ infections برضه ممكن تأثر على عمل
+
+391
+00:35:13,680 --> 00:35:17,440
+البنكرياس. ده كان صرفيا عندنا، ممكن اللي هو التهاب
+
+392
+00:35:17,440 --> 00:35:22,750
+في البنكرياس. برضه عندنا genetic conditions مختلفة
+
+393
+00:35:22,750 --> 00:35:29,310
+برضه ممكن تكون سبب في ارتفاع مستوى السكر في الدم
+
+394
+00:35:29,310 --> 00:35:32,530
+أو الجلوكوز، يعني زي الـ Down Syndrome، أو Klinefelter
+
+395
+00:35:32,530 --> 00:35:41,510
+Syndrome. وطبعا هذا مرتبط بالزيادة الوزن عند
+
+396
+00:35:41,510 --> 00:35:47,010
+هذول، برضه due to high prevalence of obesity. أيضا
+
+397
+00:35:47,010 --> 00:35:54,510
+عندنا الـ Porphyria. هذا بيؤدي الى وزيادة الـ insulin
+
+398
+00:35:54,510 --> 00:36:00,910
+resistance، وبالتالي ارتفاع مستوى الجلوكوز في الدم
+
+399
+00:36:00,910 --> 00:36:07,370
+عند هذول المرضى. النوع الرابع والأخير، إن الـ
+
+400
+00:36:07,370 --> 00:36:11,490
+gestational diabetes mellitus، اللي هو سكري الحمل
+
+401
+00:36:11,490 --> 
+
+445
+00:39:50,560 --> 00:39:54,500
+إذا كان فيه a gestational diabetes mellitus الذي
+
+446
+00:39:54,500 --> 00:39:58,640
+هو بعد الأسبوع الرابع والعشرين وبالتالي إذا كان تم
+
+447
+00:39:58,640 --> 00:40:03,000
+اكتشاف أن الست عندها ارتفاع في مستوى الجلوكوز قبل
+
+448
+00:40:03,000 --> 00:40:06,380
+الأسبوع الرابع والعشرين يبقى برضه هذا يعتبر high
+
+449
+00:40:06,380 --> 00:40:11,300
+risk لهذه السيدة للإصابة مستقبلاً بـ type 2 diabetes
+
+450
+00:40:11,300 --> 00:40:12,140
+mellitus
+
+451
+00:40:14,370 --> 00:40:17,490
+At 6 to 12 weeks postpartum, all patients who
+
+452
+00:40:17,490 --> 00:40:19,590
+had gestational diabetes mellitus should be
+
+453
+00:40:19,590 --> 00:40:24,990
+evaluated.  بيُقيَّم هؤلاء النساء اللاتي يظهر عندهن أو يعني
+
+454
+00:40:24,990 --> 00:40:28,890
+يُشخّصن على أنهنّ مصابات بـ gestational diabetes
+
+455
+00:40:28,890 --> 00:40:34,210
+mellitus، لابد أن يكون هنالك متابعة، وعادةً ما
+
+456
+00:40:34,210 --> 00:40:39,410
+يكون ذلك بعد 6 إلى 12 أسبوعًا،  يجب أن يكون لدينا تقييم
+
+457
+00:40:39,410 --> 00:40:47,170
+لهؤلاء النساء، ونعيد إجراء فحص تحمل الجلوكوز عن طريق الفم  oral glucose
+
+458
+00:40:47,170 --> 00:40:48,910
+tolerance test
+
+459
+00:40:51,380 --> 00:40:55,500
+إذا لم يكن داء السكري موجودًا، يجب أن تُجرى هذه الفحوصات
+
+460
+00:40:55,500 --> 00:40:59,360
+على مرضى داء السكري على الأقل كل ثلاث سنوات.  لا نهملهم،
+
+461
+00:40:59,360 --> 00:41:04,180
+ويجب أن تستمر متابعتنا لهؤلاء المرضى، لأن
+
+462
+00:41:04,180 --> 00:41:07,800
+كما قلنا، هؤلاء هنّ at higher risk للإصابة بـ type 2
+
+463
+00:41:07,800 --> 00:41:11,320
+diabetes mellitus، وبالتالي يجب أن تستمر متابعتهم
+
+464
+00:41:11,320 --> 00:41:14,680
+لأنّ في حال إصابتهم بالمرض يتم اكتشافه
+
+465
+00:41:14,680 --> 00:41:21,390
+مباشرةً،  ويُعالَج المرض سريعًا قبل ظهور
+
+466
+00:41:21,390 --> 00:41:25,670
+المضاعفات المختلفة.
diff --git a/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/bESKTB5yKZs_postprocess.srt b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/bESKTB5yKZs_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..3cead7f77dca85a4e1065a56db03d2aa9b7647b0
--- /dev/null
+++ b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/bESKTB5yKZs_postprocess.srt
@@ -0,0 +1,1864 @@
+1
+00:00:02,060 --> 00:00:05,600
+بسم الله الرحمن الرحيم والصلاة والسلام على خاتم
+
+2
+00:00:05,600 --> 00:00:09,280
+الأنبياء والمرسلين سيدنا محمد عليه الصلاة وأفضل
+
+3
+00:00:09,280 --> 00:00:16,960
+التسليميسعدني أن أكون معكم في مساق clinical
+
+4
+00:00:16,960 --> 00:00:23,120
+biochemistry أو كيمياء حيوية سريرية واللي ان شاء
+
+5
+00:00:23,120 --> 00:00:28,380
+الله سندرس من خلالها بعض الموضوعات التي تتعلق
+
+6
+00:00:28,380 --> 00:00:33,100
+بالكيمياء السريرية بيعني
+
+7
+00:00:33,100 --> 00:00:40,350
+تفاصيل أكتر يعني more advancedمقارنة بالدراسة اللي
+
+8
+00:00:40,350 --> 00:00:45,610
+دراستوها في ال baccalaureate تم تنزيل ال course
+
+9
+00:00:45,610 --> 00:00:51,970
+outline على صفحة ال model الموضوعات اللي سنتطرق
+
+10
+00:00:51,970 --> 00:00:58,470
+لها ان شاء الله من خلال دراستنا لهذا المساق سنبدأ
+
+11
+00:00:58,470 --> 00:01:04,410
+بال diabetes mellitus و بعد هيك هيكون في عندنا ال
+
+12
+00:01:04,410 --> 00:01:09,680
+cardiac functionطبعا زي ما قولنا يعني هنحكي بتفصيل
+
+13
+00:01:09,680 --> 00:01:13,280
+أكتر ليه
+
+14
+00:01:13,280 --> 00:01:17,680
+الأمراض المختلفة ممكن اللي بتصيب ال organs كيف
+
+15
+00:01:17,680 --> 00:01:25,120
+ممكن تشخيصها و هيكون دايما في نهاية المحاضرة في
+
+16
+00:01:25,120 --> 00:01:31,690
+بعض ال case studies اللي سنتطرق لهاعنا ايضا ال
+
+17
+00:01:31,690 --> 00:01:35,290
+kidney disease، في عنا ال disorders of water
+
+18
+00:01:35,290 --> 00:01:39,190
+electrolytes and acid base metabolism، liver
+
+19
+00:01:39,190 --> 00:01:43,370
+disease, gestric, pancreatic and intestinal
+
+20
+00:01:43,370 --> 00:01:48,800
+function و ال bone and mineral metabolismوإذا كان
+
+21
+00:01:48,800 --> 00:01:52,120
+ضال معانا وقت ان شاء الله هنشوف ال evidence-based
+
+22
+00:01:52,120 --> 00:01:57,500
+laboratory medicine هذه الموضوعات اللي هنتطرقلها
+
+23
+00:01:57,500 --> 00:02:04,500
+ان شاء الله من خلال دراستنا للمثقة طبعا
+
+24
+00:02:04,500 --> 00:02:08,280
+اللي بالنسبالنا توزيع الدرجات برضه موجود بال
+
+25
+00:02:08,280 --> 00:02:14,440
+course outline في عامة للفصل خمسة واربعين بالمية
+
+26
+00:02:15,250 --> 00:02:20,850
+عبارة عن تلاتين بالمية امتحان نصفي و هيكون فيه
+
+27
+00:02:20,850 --> 00:02:26,790
+presentation هتقدموها زي ما يعني حكيت التفاصيل على
+
+28
+00:02:26,790 --> 00:02:29,910
+مجموعة ال whatsapp هذا ال presentation عليها خمس
+
+29
+00:02:29,910 --> 00:02:33,710
+أعشر بالمية و الامتحان النهائي هيكون ان شاء الله
+
+30
+00:02:33,710 --> 00:02:40,350
+عليه خمسة و خمسين بالمية الموضوع
+
+31
+00:02:40,350 --> 00:02:44,090
+الأول اللي هنبدأ فيه هو ال diabetes malatus
+
+32
+00:02:47,990 --> 00:02:51,070
+الـ ده بيت اسمه الـ Letus group of metabolic
+
+33
+00:02:51,070 --> 00:02:57,030
+disorders يبقى مجموعة من ال disorders و اللي
+
+34
+00:02:57,030 --> 00:03:06,130
+بتشترك بخاصية و هي ارتفاع مستوى السكر في الدم يبقى
+
+35
+00:03:06,130 --> 00:03:11,210
+في عندنا hyperiglycemia خاصية مشتركة بين هذه ال
+
+36
+00:03:11,210 --> 00:03:17,080
+metabolic disordersوهذا الارتفاع بيه لـ Glucose
+
+37
+00:03:17,080 --> 00:03:24,480
+ناتج عن سبابينالسبب الأول ممكن يكون بسبب ال
+
+38
+00:03:24,480 --> 00:03:29,100
+defects in insulin secretion يكون في عندي مشكلة في
+
+39
+00:03:29,100 --> 00:03:35,200
+ال beta cells في ال pancreas اللي طبعا مسئولة عن
+
+40
+00:03:35,200 --> 00:03:38,920
+إنتاج ال insulin يمكن يكون في عندى مشكلة في ال
+
+41
+00:03:38,920 --> 00:03:42,040
+beta cells وبالتالي في عندي مشكلة في ال insulin
+
+42
+00:03:42,040 --> 00:03:47,260
+secretion أو ممكن يكون في عندي مشكلة في ال insulin
+
+43
+00:03:47,260 --> 00:03:53,140
+actionيبقى بيعمل ال insulin أو اللي هو ال
+
+44
+00:03:53,140 --> 00:03:58,580
+sensitivity of cells for insulin أو ممكن تكون
+
+45
+00:03:58,580 --> 00:04:04,540
+المشكلة بال insulin secretion و ال insulin action
+
+46
+00:04:04,540 --> 00:04:10,000
+وهذا اللي بيصير بحالات اللي هي الحالات المتقدمة من
+
+47
+00:04:10,000 --> 00:04:12,040
+ال type 2 diabetes mellitus
+
+48
+00:04:15,370 --> 00:04:20,670
+المرضى اللى بيصابه بـ Aldabeta Smellitus ممكن إذا
+
+49
+00:04:20,670 --> 00:04:25,670
+ارتفع مستوى السكر لمستويات أعلى من 600 milligram
+
+50
+00:04:25,670 --> 00:04:30,750
+per deciliter ممكن يعني يتعرضوا ل life threatening
+
+51
+00:04:30,750 --> 00:04:37,570
+conditions يمكن يكون حياتهم يعني مهددة في حال زى
+
+52
+00:04:37,570 --> 00:04:43,920
+ما اتفقنا أنه ارتفع مستوى الجلوكوز بشكل عاليو هذا
+
+53
+00:04:43,920 --> 00:04:50,220
+طبعا مرتبط بالـ ketoacidosis زي ما هنشوف و بالـ
+
+54
+00:04:50,220 --> 00:04:54,860
+hyperosmolar coma يبقى إذا كان ارتفع مستوى
+
+55
+00:04:54,860 --> 00:04:57,560
+الجلوكوز عن 600 milligram per deciliter طبعا ممكن
+
+56
+00:04:57,560 --> 00:05:03,100
+يرتفع لمستويات أعلى من هيك بكتير يبقى فيه أن بعض
+
+57
+00:05:03,100 --> 00:05:06,280
+المرضى حسب نوع السكر اللي عندهم ممكن يتعرضوا لـ
+
+58
+00:05:06,280 --> 00:05:13,370
+ketoacidosisاللي هي ممكن تصير فيه حموضة في الدم
+
+59
+00:05:13,370 --> 00:05:17,630
+وانخفاض في ال pH أو ممكن تصير فيه hyperosmolar
+
+60
+00:05:17,630 --> 00:05:24,030
+اللي هو coma اللي هو السبب الأساسي بيكون ال
+
+61
+00:05:24,030 --> 00:05:27,990
+dehydration اللي بيصير لدول المرضى
+
+62
+00:05:31,740 --> 00:05:37,700
+أيضا من ناحية أخرى ممكن يصير فيه انخفاض في مستوى
+
+63
+00:05:37,700 --> 00:05:40,860
+ال glucose بالدم وهذا برضه تعتبر life threatening
+
+64
+00:05:40,860 --> 00:05:46,480
+condition نصير في عندنا hypooglycemia برضه هذه
+
+65
+00:05:46,480 --> 00:05:52,540
+طبعا مشكلة لهدول المرضى وهذا ممكن طبعا يكون بسبب
+
+66
+00:05:52,540 --> 00:06:00,680
+العلاج يعني يكون في جرعة مثلا زيادة من ال insulin
+
+67
+00:06:01,390 --> 00:06:04,750
+أو يكون المريض أخذ الجرعه المناسبه لكن يكون بذل
+
+68
+00:06:04,750 --> 00:06:08,350
+مجهود أكبر على سبيل المثال، وجهة ده ممكن يؤدي الى
+
+69
+00:06:08,350 --> 00:06:14,410
+hypoglycemia واللي برضه طبعا أكيد يعتبر يعني مهدد
+
+70
+00:06:14,410 --> 00:06:19,710
+للحياة As
+
+71
+00:06:19,710 --> 00:06:23,070
+the disease progresses, patients are at increased
+
+72
+00:06:23,070 --> 00:06:26,050
+risk for the development of specific complications
+
+73
+00:06:26,870 --> 00:06:32,850
+بكمان ارتفاع الجلوكوز المستمر في الدم هذا هيؤدى
+
+74
+00:06:32,850 --> 00:06:37,230
+الى العديد من المشاكل المرضى العديد من ال
+
+75
+00:06:37,230 --> 00:06:41,950
+complications و هذه ال complications ممكن تكون
+
+76
+00:06:41,950 --> 00:06:48,380
+microvascular و ممكن تكون macrovascularالـ
+
+77
+00:06:48,380 --> 00:06:52,420
+Microvascular complications يعني عندنا أنثلة عديدة
+
+78
+00:06:52,420 --> 00:06:57,640
+زي اللي هو الـ Retinopathy تصير في عندنا مشكلة في
+
+79
+00:06:57,640 --> 00:07:03,700
+الشبكية و اللي ممكن تؤدي إلى العمى أيضًا ممكن تصير
+
+80
+00:07:03,700 --> 00:07:09,300
+في عندنا مشكلة بالـ Microviscles في ال kidney و
+
+81
+00:07:09,300 --> 00:07:12,820
+اللي ممكن تؤدي إلى Nephropathy و ممكن ينتهي المريض
+
+82
+00:07:12,820 --> 00:07:19,590
+بـ Renal Failureوعنا يعني عدد مش بسيط من ال ..
+
+83
+00:07:19,590 --> 00:07:27,700
+المرضى اللي عندهم renal failure هم مرضى سكريأيضا
+
+84
+00:07:27,700 --> 00:07:32,560
+الـ neuropathy برضه ممكن تصير في عنا مشكلة في ال
+
+85
+00:07:32,560 --> 00:07:36,780
+.. على مستوى الأعصاب و اللي ممكن تؤدي إلى nerve
+
+86
+00:07:36,780 --> 00:07:40,660
+damage يعني ال complications اللي مرتبطة بارتفاع
+
+87
+00:07:40,660 --> 00:07:44,020
+مستوى الجلوكوز في الدم عديدة زي ما قلنا
+
+88
+00:07:44,020 --> 00:07:47,300
+microvascular وفي عنا ال macrovascular
+
+89
+00:07:48,790 --> 00:07:53,890
+اللي هو في الـ atherosclerosis تصلب الشرايين و
+
+90
+00:07:53,890 --> 00:07:58,610
+طبعا اللي ال atherosclerosis تقدي إلى ضيق في
+
+91
+00:07:58,610 --> 00:08:03,170
+الأوعية الدموية في الشرايين و اللي ممكن ينتهي
+
+92
+00:08:03,170 --> 00:08:08,470
+الأمر بانسداد كامل للشريان و بالتالي المنطقة اللي
+
+93
+00:08:08,470 --> 00:08:14,270
+بيغضيها هذا الشريان هتنحرم من ال oxygen و طبعا
+
+94
+00:08:14,270 --> 00:08:23,470
+ممكن يعني يصير فينا موتلهذا الجزء يبقى ال
+
+95
+00:08:23,470 --> 00:08:27,450
+atherosclerosis حسب المشكلة في أي شريان موجود ممكن
+
+96
+00:08:27,450 --> 00:08:31,650
+هذا يؤدي إلى stroke إذا كان عندنا ال
+
+97
+00:08:31,650 --> 00:08:37,350
+atherosclerosis في ال arteries اللي بتغذي المخ
+
+98
+00:08:37,350 --> 00:08:41,590
+فيانا ممكن إذا كان صار في atherosclerosis بالشريان
+
+99
+00:08:41,590 --> 00:08:45,710
+اللي بتغذي الأطراف وصار في عندنا انستداد كامل هذا
+
+100
+00:08:45,710 --> 00:08:52,690
+ممكن يؤدي إلى gangreneوإذا كان عندنا الشريان اللي
+
+101
+00:08:52,690 --> 00:08:56,750
+فيه المشكلة هو اللي بيغذي عضلة القلب تمام في حالة
+
+102
+00:08:56,750 --> 00:08:59,710
+اللي بقول ان ال artery disease بيحدث ممكن يؤدي إلى
+
+103
+00:08:59,710 --> 00:09:04,610
+يعني موت جزء من عضلة القلب طبعا حسب اللي هو
+
+104
+00:09:04,610 --> 00:09:09,530
+الشريان اللي صار فيه عندنا اللي هو انسداد كامل
+
+105
+00:09:09,530 --> 00:09:13,750
+يبقى ال complications عديدة و أيضا خطيرة
+
+106
+00:09:18,750 --> 00:09:23,710
+طبعا مشكلة ال .. ال .. السكري او مرض السكري يعني
+
+107
+00:09:23,710 --> 00:09:30,110
+مشكلة كبيرة و المشكلة كل ما لها ايضا بيه ازدياد و
+
+108
+00:09:30,110 --> 00:09:36,570
+اعداد الناس اللي بتصاب بيه السكري بتزيد بشكل غير
+
+109
+00:09:36,570 --> 00:09:43,090
+اللي هو او اعلى من المتوقع دائما number of people
+
+110
+00:09:43,090 --> 00:09:46,050
+with diabetes has increased dramatically worldwide
+
+111
+00:09:47,910 --> 00:09:55,930
+عنا بيه الـ 2013 كان عدد المرضى 382 مليون ومتوقع
+
+112
+00:09:55,930 --> 00:10:03,990
+أنه يزيد العدد لـ 592 مليون هذا في العام 2035 يبقى
+
+113
+00:10:03,990 --> 00:10:09,250
+العدد كان بـ 2013 382 مليون وبناء على الحسابات
+
+114
+00:10:09,250 --> 00:10:14,410
+اللي عملوها اتوقعوا أنه بيه الـ 2035 يصير 592
+
+115
+00:10:14,410 --> 00:10:29,240
+مليونفي 2019 العدد وصل لـ 463 مليون 463 مليون يبقى
+
+116
+00:10:29,240 --> 00:10:34,140
+بالـ 2035 أكيد العدد هيكون أكبر بكتير من الوطن
+
+117
+00:10:34,140 --> 00:10:41,950
+توقعه في العام 2013 ويعني صار المتوقع بناء على
+
+118
+00:10:41,950 --> 00:10:49,230
+العدد المرضى في عام 2019 صار المتوقع أنه بالـ 2540
+
+119
+00:10:49,230 --> 00:10:55,190
+يصل العدد إلى 700 مليون مريض بالسكري
+
+120
+00:11:01,180 --> 00:11:04,260
+this number is predicted to reach 592 زي ما قولنا
+
+121
+00:11:04,260 --> 00:11:07,500
+في العام الفين و خمس و تلاتين eighty percent of
+
+122
+00:11:07,500 --> 00:11:11,220
+whom will live in low and middle income countries
+
+123
+00:11:11,220 --> 00:11:15,860
+يعني العدد الأكبر من المرضى هيكونوا موجودين في
+
+124
+00:11:15,860 --> 00:11:22,640
+اللي هي البلاد اللي مستوى الدخل فيها يعني منخفض أو
+
+125
+00:11:22,640 --> 00:11:29,720
+متوسطهذا الشكل بيوضح اللي هو توزيع الأعداد اللي ..
+
+126
+00:11:29,720 --> 00:11:34,500
+اللي هي الـ 382 اللي حكينا كانت بالـ 2013 على اللي
+
+127
+00:11:34,500 --> 00:11:38,800
+هي المناطق المختلفة أو القارات المختلفة ليه اللي
+
+128
+00:11:38,800 --> 00:11:43,840
+هو العالم وهو عندنا يعني مبين اللي .. اللي هو
+
+129
+00:11:43,840 --> 00:11:51,480
+عندنا الصين اللي هو أعلى عدد من المرضى اليومية
+
+130
+00:11:51,480 --> 00:11:53,580
+تمانية أو تلاتين مليون
+
+131
+00:11:55,680 --> 00:12:02,460
+المشكلة أيضًا إنه في عندنا نسبة من الناس مصابة
+
+132
+00:12:02,460 --> 00:12:08,760
+بمرض السكري لكن undiagnosed والمشكلة إنه هذا العدد
+
+133
+00:12:08,760 --> 00:12:14,620
+مش بسيط يعني إحنا لما بنحكي على 382 مليون شخص هدول
+
+134
+00:12:14,620 --> 00:12:19,210
+تم تشخيصهم إنهم مصابين بالـ diabetes mellitus
+
+135
+00:12:19,210 --> 00:12:27,530
+بالمقابل في عندنا 175 مليون هدول undiagnosed يبقى
+
+136
+00:12:27,530 --> 00:12:35,590
+دايما العدد فعليا الناس المصابة هو أكبر من الأرقام
+
+137
+00:12:35,590 --> 00:12:36,830
+المعلنة
+
+138
+00:12:38,600 --> 00:12:43,820
+ويعني هذه برضه مشكلة أنه مايتمش اكتشاف المرض بشكل
+
+139
+00:12:43,820 --> 00:12:50,300
+سريع وعادة يعني مرضى السكري ممكن يتم ال diagnosis
+
+140
+00:12:50,300 --> 00:12:56,820
+لهم ويكون فعليا بدت عندنا ال complications بالظهور
+
+141
+00:12:56,820 --> 00:13:00,640
+يبقى بيكون عندنا ال diagnosis صارت متأخرة بشكل
+
+142
+00:13:00,640 --> 00:13:01,700
+كبير
+
+143
+00:13:06,200 --> 00:13:09,480
+acute and chronic complications make diabetes the
+
+144
+00:13:09,480 --> 00:13:12,700
+fourth most common cause of death in the developed
+
+145
+00:13:12,700 --> 00:13:16,060
+world يبقى ال complications العديدة اللي حاكينا
+
+146
+00:13:16,060 --> 00:13:21,160
+عليها اللي هو سواء ال .. الارتفاع اللي .. اللي هو
+
+147
+00:13:21,160 --> 00:13:23,840
+مستوى ال glucose و ال life threatening conditions
+
+148
+00:13:23,840 --> 00:13:27,660
+اللي ممكن اللي هو تصير مع ال complications اللي هي
+
+149
+00:13:28,020 --> 00:13:31,860
+على مستوى ال micro vessels أو ال macro vessels هذه
+
+150
+00:13:31,860 --> 00:13:40,600
+بتؤدي إلى يعني موت مرضى السكري ويعتبر يعني الموت
+
+151
+00:13:40,600 --> 00:13:48,540
+من المرض الورابع سبب للموت in the developed world
+
+152
+00:13:53,890 --> 00:14:01,310
+Diabetes caused 5.1 million deaths in 2013 وهذا
+
+153
+00:14:01,310 --> 00:14:08,750
+اللي هو بيمثل يعني أن الشخص بيموت كل ست ثواني بسبب
+
+154
+00:14:08,750 --> 00:14:10,110
+مرض السكري
+
+155
+00:14:13,910 --> 00:14:18,910
+ال .. أيضًا ال .. المرض السكري و الرعاية اللى
+
+156
+00:14:18,910 --> 00:14:28,030
+بتقدمها الدول للمرضى برضه تكلفتها عالية جدًا تكلفت
+
+157
+00:14:28,030 --> 00:14:34,900
+اللى هو المتابعة للمرضى تكلفت العلاج تكلفتاللي هي
+
+158
+00:14:34,900 --> 00:14:40,240
+ال complications ودخول المستشفيات للهو الأسباب
+
+159
+00:14:40,240 --> 00:14:48,760
+المختلفة يبقى هذه التكلفة عالية والتكلفة بال 2013
+
+160
+00:14:48,760 --> 00:14:56,800
+كانت خمسمية تمانية واربعين billion دولار يبقى
+
+161
+00:14:59,050 --> 00:15:06,710
+548 مليار دولار هذه التكلفة ومتوقع أنه التكلفة
+
+162
+00:15:06,710 --> 00:15:15,070
+تزيد في العام 2035 لـ 627 مليار
+
+163
+00:15:15,070 --> 00:15:22,090
+دولار ولكن فعليا حسب الإحصائيات اللي عملوها بيه
+
+164
+00:15:22,090 --> 00:15:30,380
+الـ 2019 التكلفةعلى هذا اللي هو القطاع وصلت 760
+
+165
+00:15:30,380 --> 00:15:37,590
+مليار دولارزي ما قلنا إنه دايماً الأعداد يعني
+
+166
+00:15:37,590 --> 00:15:42,810
+بتفوق المتوقع وبالتالي أيضاً اللي هو التكلفة
+
+167
+00:15:42,810 --> 00:15:46,130
+وتكلفة تقديم الخدمة الصحية لهذه اللي هو الفئة من
+
+168
+00:15:46,130 --> 00:15:50,550
+المرضى برضه بتفوق المتوقع يعني هان وصلت كان متوقع
+
+169
+00:15:50,550 --> 00:15:58,850
+إنه بـ 2530 تصل 627 مليار بالـ 2019 وصلت 760 مليار
+
+170
+00:16:02,900 --> 00:16:05,260
+طيب بالنسبة لها ال classification of diabetes
+
+171
+00:16:05,260 --> 00:16:10,900
+mellitus ممكن نقسم ال diabetes mellitus إلى أربع
+
+172
+00:16:10,900 --> 00:16:15,680
+أقسام أساسية في عندنا ال type 1 diabetes وممكن
+
+173
+00:16:15,680 --> 00:16:19,840
+نقسمه إلى قسمين ال immune mediated و ال idiopathic
+
+174
+00:16:19,840 --> 00:16:22,560
+في عندنا ال type 2 diabetes في عندنا ال other
+
+175
+00:16:22,560 --> 00:16:26,800
+specific types وعندنا
+
+176
+00:16:26,800 --> 00:16:33,010
+ال gestational diabetes mellitusحنحكي شوية بتفصيل
+
+177
+00:16:33,010 --> 00:16:39,570
+عن هذه الأنواع المختلفة ونبدأ بالـ Type 1 Diabetes
+
+178
+00:16:39,570 --> 00:16:43,410
+Approximately
+
+179
+00:16:43,410 --> 00:16:47,250
+5% to 10% of all cases of diabetes mellitus يبقى 5
+
+180
+00:16:47,250 --> 00:16:52,570
+إلى 10% من مرضى السكر هم عبارة عن مرضى من النوع
+
+181
+00:16:52,570 --> 00:16:59,470
+الأولو هدول المرضى عادة بيكون عندنا ال .. ال ..
+
+182
+00:16:59,470 --> 00:17:04,970
+المشكلة اللي هي abrupt onset يعني مش زي ال type 2
+
+183
+00:17:04,970 --> 00:17:09,800
+ممكن المريض يقعد سنتين و تلاتةواللي هو عنده
+
+184
+00:17:09,800 --> 00:17:15,280
+المشكلة أو يعني عشان يصير تطور لهذه المشكلة وفيه
+
+185
+00:17:15,280 --> 00:17:18,740
+طبعا مرحلة اللي هو الـ Prediabetes لكن هان في الـ
+
+186
+00:17:18,740 --> 00:17:24,160
+Type 1 في عندنا abrupt onset يعني عندنا الفترة
+
+187
+00:17:24,160 --> 00:17:28,700
+اللي هي الظهور المرض يعني بتكون هي كانت زي فجأة
+
+188
+00:17:29,570 --> 00:17:34,090
+they have abrupt onset of symptoms اللي هو زي ال
+
+189
+00:17:34,090 --> 00:17:43,550
+polyuria polydipsia و ال weight loss they have
+
+190
+00:17:43,550 --> 00:17:49,310
+encephalopenia deficiency of insulin و زي ما احنا
+
+191
+00:17:49,310 --> 00:17:55,640
+عارفين انه ال type oneبصير في عنا المشكلة في ال
+
+192
+00:17:55,640 --> 00:18:00,220
+beta cells بصير في عنا destruction ل ال beta cells
+
+193
+00:18:00,220 --> 00:18:04,300
+الموجودة في ال islets of Langerhans في ال pancreas
+
+194
+00:18:04,300 --> 00:18:09,090
+وهي المسئولة طبعاعن إنتاج الإنسونين وإذا كان سر
+
+195
+00:18:09,090 --> 00:18:13,030
+فيانا destruction لهذه الخلايا اللي بتنتج
+
+196
+00:18:13,030 --> 00:18:18,510
+الإنسونين بيحصل فيانا انسروبينيا نقص شديد اللي هو
+
+197
+00:18:18,510 --> 00:18:22,710
+للإنسونين اللي ممكن يؤدي بالنهاية ل deficiency of
+
+198
+00:18:22,710 --> 00:18:27,530
+insulin dependent
+
+199
+00:18:27,530 --> 00:18:32,050
+on insulin to sustain life and prevent ketosisيبقى
+
+200
+00:18:32,050 --> 00:18:35,930
+مزال في عندنا absolute deficiency of insulin يبقى
+
+201
+00:18:35,930 --> 00:18:41,890
+هذا النوع من المرضى يبقى يعتمد اعتماد كامل على ال
+
+202
+00:18:41,890 --> 00:18:49,130
+insulin عشان يضلهم عايشين لازم يتم اعطائهم جرعات
+
+203
+00:18:49,130 --> 00:18:54,630
+من ال insulin يومياوعشان هيك كان اللي هو الاسم
+
+204
+00:18:54,630 --> 00:18:59,450
+السابق لـ Type 1 Diabetes كان Insulin Dependent
+
+205
+00:18:59,450 --> 00:19:03,990
+Diabetes Mellitus يبقى لابد من اللي هو أعطاهم
+
+206
+00:19:03,990 --> 00:19:10,390
+الإنسولين to sustain life وأيضا عشان نمنع حدوث الـ
+
+207
+00:19:10,390 --> 00:19:13,470
+Ketosis أو الـ Ketoacidosis
+
+208
+00:19:19,950 --> 00:19:23,930
+معظم المستخدمين لديها مخلوقات تشير إلى تجارب عملية
+
+209
+00:19:23,930 --> 00:19:25,710
+تجارب عملية
+
+210
+00:19:28,190 --> 00:19:31,270
+زي ما حكينا أنه الـ Type 1 ممكن اللي هو ينقسم إلى
+
+211
+00:19:31,270 --> 00:19:35,450
+قسمين، فينا الـ immune-mediated وفينا الـ
+
+212
+00:19:35,450 --> 00:19:39,270
+idiopathic، يبقى ما زال بحكي immune-mediated وطبعا
+
+213
+00:19:39,270 --> 00:19:43,450
+هذا اللي بيشكل النسبة الأكبر لاللي هو الـ Type 1
+
+214
+00:19:43,450 --> 00:19:45,770
+diabetes mellitus اللي هو النسبة الأكبر بيكون
+
+215
+00:19:45,770 --> 00:19:52,590
+immune-mediated يبقى ممكن يكون في عندنا antibodies
+
+216
+00:19:53,940 --> 00:19:57,760
+أو ممكن اللي هو تم الكشف عن antibodies عند هدول
+
+217
+00:19:57,760 --> 00:20:02,760
+المرضى Some
+
+218
+00:20:02,760 --> 00:20:05,400
+have no evidence of autoimmunity and are
+
+219
+00:20:05,400 --> 00:20:09,500
+classified as type 1-idiopathic وهذه اللي بتمثل
+
+220
+00:20:09,500 --> 00:20:14,780
+نسبة قليلة من مرضى الـtype 1 The big incidence
+
+221
+00:20:14,780 --> 00:20:20,610
+occurs in childhood and adolescenceوعشان هيك البعض
+
+222
+00:20:20,610 --> 00:20:24,730
+بيطلق عليه الواقع juvenile diabetes لأنه النسبة
+
+223
+00:20:24,730 --> 00:20:29,810
+الأكبر لالناس اللي بيوصابوا اللي بيكونوا أطفال
+
+224
+00:20:29,810 --> 00:20:33,870
+تقريبا 75% acquired the disease before the age of
+
+225
+00:20:33,870 --> 00:20:38,730
+18 but onset and the remainder may occur at any
+
+226
+00:20:38,730 --> 00:20:39,350
+age
+
+227
+00:20:43,770 --> 00:20:47,150
+النوع التاني اللي عندنا هو ال type 2 diabetes
+
+228
+00:20:47,150 --> 00:20:51,190
+mellitus طبعا ده بيمثل النسبة الأكبر من ال
+
+229
+00:20:51,190 --> 00:20:56,230
+diabetes mellitus اللي هو أكتر من 90% of all cases
+
+230
+00:20:56,230 --> 00:21:01,350
+of diabetes patients have minimal symptoms are not
+
+231
+00:21:01,350 --> 00:21:09,370
+prone to ketosis طبعا موضوع ال ketosis مرتبط بوجود
+
+232
+00:21:09,370 --> 00:21:16,190
+ال insulin أو عدم وجود ال insulinحكينا بيه الـ
+
+233
+00:21:16,190 --> 00:21:21,090
+Type 1 إنه مرضى الـ Type 1 بيتمدوا على الانسولين
+
+234
+00:21:21,090 --> 00:21:27,030
+to sustain life و زمون عشان نمنع الـ Ketosis لأن
+
+235
+00:21:27,030 --> 00:21:36,870
+عدم وجود الانسولين هذا يؤدي إلى زيادة بشكل كبير في
+
+236
+00:21:36,870 --> 00:21:38,590
+هرمون الـ glucagon
+
+237
+00:21:41,150 --> 00:21:44,270
+يبقى بزيد عندنا الجلوكاجون وبالتالي الجلوكاجون
+
+238
+00:21:44,270 --> 00:21:49,510
+بيزيد من الوالي glycogenolysis وبيزيد ايضا من
+
+239
+00:21:49,510 --> 00:21:54,950
+الجلوكونيوجينيسي نعم يبقى بزيد من الجلوكونيوجينيسي
+
+240
+00:21:54,950 --> 00:21:58,790
+وبالتالي بيزيد من اللي هو تصنيع ال carbohydrates
+
+241
+00:21:58,790 --> 00:22:03,570
+from non carbohydrate sources زي ال libids وهذا
+
+242
+00:22:03,570 --> 00:22:10,000
+بيؤدى الى إنتاج كميات كبيرة من ال ketone bodiesو
+
+243
+00:22:10,000 --> 00:22:14,900
+الـ ketone bodies اللي هو acidic و بيعملوا على خفض
+
+244
+00:22:14,900 --> 00:22:22,400
+ال pH للدم لكن
+
+245
+00:22:22,400 --> 00:22:29,050
+بال type 2 ال insulin موجودطبعا يبقى ما زال ال
+
+246
+00:22:29,050 --> 00:22:33,930
+insulin موجود يبقى ال insulin بيعمل inhibition على
+
+247
+00:22:33,930 --> 00:22:38,930
+ال ال alpha cells وبالتالي بيقلل او بيمنع من افراز
+
+248
+00:22:38,930 --> 00:22:44,450
+ال glucagon عشان
+
+249
+00:22:44,450 --> 00:22:47,390
+هيك بنقول ان ال patients have minimal symptoms و
+
+250
+00:22:47,390 --> 00:22:51,950
+are not prone to ketosis ليش they are not prone to
+
+251
+00:22:51,950 --> 00:22:54,810
+ketosis لأن ال insulin موجود
+
+252
+00:22:56,880 --> 00:23:01,680
+are not dependent on insulin to prevent ketonuria
+
+253
+00:23:01,680 --> 00:23:07,720
+يبقى بيعتمدوش على اللي هو ال insulin زي ما قلنا
+
+254
+00:23:07,720 --> 00:23:11,380
+لمنع اللي هو طبعا إنتاج ال ketone bodies اللي ممكن
+
+255
+00:23:11,380 --> 00:23:14,700
+تظهر بعد هيك طبعا في يعني تكون موجودة في الدم
+
+256
+00:23:14,700 --> 00:23:20,950
+وأيضا بتبدأ تظهر في ال urine لأن they are notاللي
+
+257
+00:23:20,950 --> 00:23:24,110
+هو insulin dependent وعشان ات كانوا زمان ال type 2
+
+258
+00:23:24,110 --> 00:23:28,330
+diabetes يسمى non-insulin dependent لكن طبعا تم
+
+259
+00:23:28,330 --> 00:23:32,150
+تغيير هذا الاسم لأنه لاجوا أنه المرضى من النوع
+
+260
+00:23:32,150 --> 00:23:37,570
+التاني ممكن في الحالات المتقدمة ممكن يصيروا
+
+261
+00:23:37,570 --> 00:23:43,200
+يعتمدوا على ال insulin يبقى في مراحل متقدمةمن
+
+262
+00:23:43,200 --> 00:23:48,240
+المرض ممكن يبدأ ال type 2 diabetes malatus patient
+
+263
+00:23:48,240 --> 00:23:53,640
+ممكن يبدأ ياخد insulin insulin
+
+264
+00:23:53,640 --> 00:23:57,500
+concentrations may be normal decreased or
+
+265
+00:23:57,500 --> 00:24:00,960
+increased and most people with this form of
+
+266
+00:24:00,960 --> 00:24:06,220
+diabetes have impaired insulin action يبقى لو
+
+267
+00:24:06,220 --> 00:24:10,390
+أجينا فحثنا مستويات ال insulinممكن نلاقي إنه
+
+268
+00:24:10,390 --> 00:24:17,510
+المستويات طبيعية أو نلاقي إنه المستويات أقل من
+
+269
+00:24:17,510 --> 00:24:25,810
+الطبيعي أو أكتر من الطبيعي طبعا في البداية يعني بس
+
+270
+00:24:25,810 --> 00:24:31,350
+تبدأ ترتفع أنه مستويات الجلوكوز الـ pancreas أكيد
+
+271
+00:24:31,350 --> 00:24:37,920
+بيبدأ يزيد من إنتاجه للإنسلينلأن دي يعمل ال
+
+272
+00:24:37,920 --> 00:24:42,560
+compensation لإن ال glucose زاد يبقى ال ال
+
+273
+00:24:42,560 --> 00:24:47,400
+pancreas بده يفرز أكتر insulin عشان يحافظ على
+
+274
+00:24:47,400 --> 00:24:52,940
+مستوى ال glucose ضمن ال reference intervalيعني
+
+275
+00:24:52,940 --> 00:24:56,700
+ممكن في البدايات تلاقي أنه ال .. الـ Glucose
+
+276
+00:24:56,700 --> 00:25:02,360
+الانسولين ال concentration ممكن تبدأ ترتفع لكن مع
+
+277
+00:25:02,360 --> 00:25:06,200
+الاستمرار في الارتفاع لمستوى الـ Glucose ممكن يبدأ
+
+278
+00:25:06,200 --> 00:25:11,160
+يصير في عنا اللي هويعني انهاج ليه البنكرياس
+
+279
+00:25:11,160 --> 00:25:17,100
+وبالتالي ممكن تبدأ بعد هيك ليه مستويات ال insulin
+
+280
+00:25:17,100 --> 00:25:23,000
+تبدأ بالانخفاض وزي ما قلنا اللي هو في يعني مراحل
+
+281
+00:25:23,000 --> 00:25:28,780
+متقدمة ممكن يبدأ المريض ال type 2 اللي هو يعتمد
+
+282
+00:25:28,780 --> 00:25:32,040
+على اللي هو ال insulin الخارجي
+
+283
+00:25:36,520 --> 00:25:39,520
+طبعاً هذا انه زي ما قلنا انه فيه impaired insulin
+
+284
+00:25:39,520 --> 00:25:43,760
+action في عندنا هان مشكلة في عمل ال insulin في
+
+285
+00:25:43,760 --> 00:25:47,160
+عندنا ال sensitivity of cells to insulin اللي هو
+
+286
+00:25:47,160 --> 00:25:54,920
+أقل من الطبيعي وبالتالي بتحتاج إلى concentrations
+
+287
+00:25:54,920 --> 00:26:03,320
+أعلى من ال insulin عشان تقوم بالوظيفة المطلوبة ال
+
+288
+00:26:03,320 --> 00:26:10,310
+obesity بتلعبدور في ال type 2 diabetes مالليتاس
+
+289
+00:26:10,310 --> 00:26:16,390
+obesity is commonly associated ال ال ال obesity و
+
+290
+00:26:16,390 --> 00:26:19,030
+أيضا ال يعني في بعض الأشخاص اللي بيكونوا
+
+291
+00:26:19,030 --> 00:26:26,280
+overweight يبقى obese أو ممكن overweightوعشان هيك
+
+292
+00:26:26,280 --> 00:26:29,520
+ال weight loss alone usually improves
+
+293
+00:26:29,520 --> 00:26:34,000
+hyperglycemia يعني عادة اللي هو مرضى السكري
+
+294
+00:26:34,000 --> 00:26:38,900
+النصيحة الأولى اللي بوجهالهم الطبيب أنه لازم
+
+295
+00:26:38,900 --> 00:26:46,260
+ينزلوا وزنهم لو نزلوا وزنهم هذا ممكن يحسن من
+
+296
+00:26:46,260 --> 00:26:53,880
+مستويات ال glucose عندهموالناس اللي لسه في مرحلة
+
+297
+00:26:53,880 --> 00:26:58,960
+الـ Prediabetes لو نزلوا وزنهم، لعبوا رياضة، غيروا
+
+298
+00:26:58,960 --> 00:27:04,200
+نمط حياتهم، ممكن يعني أخرقوا بشكل كبير الإصابة
+
+299
+00:27:04,200 --> 00:27:09,660
+بالـ Type 2 However,
+
+300
+00:27:09,700 --> 00:27:12,700
+many individuals with Type 2 diabetes mellitus may
+
+301
+00:27:12,700 --> 00:27:16,220
+require dietary intervention, oral, anti
+
+302
+00:27:16,220 --> 00:27:20,090
+-hyperglycemic agentsor insulin to control
+
+303
+00:27:20,090 --> 00:27:25,630
+hyperglycemia طبعا
+
+304
+00:27:25,630 --> 00:27:30,570
+أول شغلة بيبدأ فيها الطبيب في حالة ال diagnosis
+
+305
+00:27:30,570 --> 00:27:34,590
+لشخص ب type 2 diabetes mellitus هو ال dietary
+
+306
+00:27:34,590 --> 00:27:42,230
+intervention يبقى لفترة إذا اتحسن مستوى ال glucose
+
+307
+00:27:42,230 --> 00:27:45,730
+ممكن اللي هو يستمروا ب اللي هو ال diet أو ال
+
+308
+00:27:45,730 --> 00:27:49,470
+dietary intervention لكنلو دال ال .. ال .. ال
+
+309
+00:27:49,470 --> 00:27:53,910
+glucose مرتفع بيبدأ لو بيعطاء الأدوية اللي هي ال
+
+310
+00:27:53,910 --> 00:27:58,610
+oral anti-hyperglycemic agents وزي ما قولنا في
+
+311
+00:27:58,610 --> 00:28:05,570
+مراحل متقدمة من المرض ممكن الطبي بيلجأ إلى ال
+
+312
+00:28:05,570 --> 00:28:09,470
+insulin most
+
+313
+00:28:09,470 --> 00:28:12,750
+patients acquired disease after age 40 got it may
+
+314
+00:28:12,750 --> 00:28:20,630
+occur in younger peopleيبقى زمان كان ال .. يعني
+
+315
+00:28:20,630 --> 00:28:26,890
+الناس اللي بيصابوا عادة بيكونوا فوق الأربعين لكن
+
+316
+00:28:26,890 --> 00:28:33,370
+الآن صار في أطفال بيصابوا ب ال type 2 diabetes
+
+317
+00:28:33,370 --> 00:28:39,190
+malitus طبعا هذا بيرجع ليه اللي هو نوع الطعام اللي
+
+318
+00:28:39,190 --> 00:28:45,480
+بنتناوله اللي هو الطعام الغير صحينمط الحياة اللي
+
+319
+00:28:45,480 --> 00:28:52,440
+بنعيشه اللي هو كله يعني خمول وفيش حركة وفيش رياضة
+
+320
+00:28:52,440 --> 00:28:59,300
+تمام و بالتالي هذا يعني أدى إلى انخفاض في العمر
+
+321
+00:28:59,300 --> 00:29:03,300
+للي اللي هو حدوث هذا المرض.
+
+322
+00:29:05,680 --> 00:29:08,620
+Type 2 diabetes mellitus في الأولواء والأطفال هو
+
+323
+00:29:08,620 --> 00:29:16,500
+مشكلة مهمة كثيرة زي ما قلنا هذا يعني مرتبط بالطعام
+
+324
+00:29:16,500 --> 00:29:25,000
+والحياة اللي بنعيشها حاليا among children in Japan
+
+325
+00:29:25,000 --> 00:29:28,480
+in 1998 Type 2 diabetes mellitus was more common
+
+326
+00:29:28,480 --> 00:29:33,340
+than Type 1 accounting for 80% of childhood
+
+327
+00:29:33,340 --> 00:29:40,110
+diabetesطبعا يبقى في ال 98 في اليابان كان نسبة
+
+328
+00:29:40,110 --> 00:29:47,330
+عالية من الأطفال مصابين بال type 2 diabetes و أكتر
+
+329
+00:29:47,330 --> 00:29:51,370
+طبعا من الأطفال اللي مصابين بيه اللي هو ال type 1
+
+330
+00:29:51,370 --> 00:29:54,330
+نحنا بيقولنا اللي هو ال type 1 عادة هو juvenile
+
+331
+00:29:54,330 --> 00:29:59,390
+لكن بسبب اللي هو زي ما قلنا الطعام و الحياةاللي
+
+332
+00:29:59,390 --> 00:30:05,530
+بعيش هذه الأطفال صار في إصابات عالية عندهم بالـ
+
+333
+00:30:05,530 --> 00:30:09,790
+Type 2 ال
+
+334
+00:30:09,790 --> 00:30:13,510
+class التالت specific types of diabetes mellitus
+
+335
+00:30:13,510 --> 00:30:18,750
+due to other causes يهان عندنا ال diabetes
+
+336
+00:30:18,750 --> 00:30:24,050
+mellitus أو الـ hyperglycemia هي secondary ل
+
+337
+00:30:24,050 --> 00:30:30,650
+primary diseaseما في عندنا مشكلة أساسية ونتيجة هذه
+
+338
+00:30:30,650 --> 00:30:35,810
+المشكلة صار في عندنا ارتفاع في الجلوكوز this
+
+339
+00:30:35,810 --> 00:30:38,610
+subclass includes uncommon patients in whom
+
+340
+00:30:38,610 --> 00:30:41,710
+hyperglycemia is due to a specific underlying
+
+341
+00:30:41,710 --> 00:30:46,330
+disorder إذا ما قولنا له secondary لا disorder أو
+
+342
+00:30:46,330 --> 00:30:54,570
+مشكلة موجودة وعندنا من الأسباب ال genetic defects
+
+343
+00:30:54,570 --> 00:30:59,730
+of beta cell functionواللي هو هذا النوع اللي بيطلق
+
+344
+00:30:59,730 --> 00:31:05,650
+عليه maturity onset the betas of the young يعني في
+
+345
+00:31:05,650 --> 00:31:11,710
+عندنا مشكلة بال beta cell function وبالتالي بيكون
+
+346
+00:31:11,710 --> 00:31:20,410
+في عندنا انخفاض في المستوى ال insulin genetic
+
+347
+00:31:20,410 --> 00:31:24,850
+defectsin insulin action ممكن يكون في عندنا
+
+348
+00:31:24,850 --> 00:31:28,550
+genetic defect في نفس الانسولين type A insulin
+
+349
+00:31:28,550 --> 00:31:31,930
+resistance syndrome due to insulin receptor gene
+
+350
+00:31:31,930 --> 00:31:39,190
+mutations المشكلة في ال receptor او mutation في ال
+
+351
+00:31:39,190 --> 00:31:43,450
+ال ال هو ال insulin receptor gene
+
+352
+00:31:46,790 --> 00:31:51,490
+برضه عندنا الأمراض اللى بتصيب ال pancreas برضه هذه
+
+353
+00:31:51,490 --> 00:31:58,170
+ممكن تؤدي إلى يعني انخفاض في ال release of insulin
+
+354
+00:31:58,170 --> 00:32:04,770
+زى ال cystic fibrosisأه زي ما انتوا عارفين اللي هو
+
+355
+00:32:04,770 --> 00:32:09,150
+ال .. هذا بيعمل viscous and mucous وبالتالي يعني
+
+356
+00:32:09,150 --> 00:32:15,710
+بيمنع من ال .. أو بيأثر يعني على وظيفة ال بنكرياس
+
+357
+00:32:15,710 --> 00:32:20,190
+بشكل عام وبالتالي بيقلل من ال release of insulin
+
+358
+00:32:20,190 --> 00:32:26,500
+أيضا فينا ال endocrinopathiesالمشكلات اللي متعلقة
+
+359
+00:32:26,500 --> 00:32:30,900
+بالأمراض الهرمونات زي في عندنا اللي هو الـ
+
+360
+00:32:30,900 --> 00:32:35,160
+Cauchin's Syndrome وهذا طبعا اللي بيقدّي إلى
+
+361
+00:32:35,160 --> 00:32:39,180
+ارتفاع في الكورتزول وزي ما انتوا عارفين الكورتزول
+
+362
+00:32:39,180 --> 00:32:45,800
+هو عبارة عن hyperglycemic agent بيعبر عن هرمون
+
+363
+00:32:45,800 --> 00:32:50,960
+اللي هو بيزيد من لمستويات الجلوكوز في الدم الـ
+
+364
+00:32:50,960 --> 00:32:57,070
+Acromegalyو يكون في عنا زيادة في الـ Growth
+
+365
+00:32:57,070 --> 00:32:58,910
+hormone والـ Growth hormone برضه بيعتبر
+
+366
+00:32:58,910 --> 00:33:05,820
+hyperglycemic agentو ال glycagonoma اللي هو عندنا
+
+367
+00:33:05,820 --> 00:33:10,900
+form of pancreatic cancer اللي بيصير فيه عندنا
+
+368
+00:33:10,900 --> 00:33:17,120
+إنتاج لكميات كبيرة من ال glycagon و برضه زي ما
+
+369
+00:33:17,120 --> 00:33:21,620
+انتوا عارفين ال glycagon هو عبارة عن hyperglycemic
+
+370
+00:33:21,620 --> 00:33:26,880
+agents من الهرمونات اللي بترفع مستويات ال glucose
+
+371
+00:33:26,880 --> 00:33:33,550
+في الدمإن أيضًا إعطاء المرضايا بعض ال .. الهرمونات
+
+372
+00:33:33,550 --> 00:33:40,370
+أو ممكن بعض الأدوية، هذا ممكن يأثر على الـ beta
+
+373
+00:33:40,370 --> 00:33:42,750
+cell function اللي هو على سبيل المثال أو ممكن
+
+374
+00:33:42,750 --> 00:33:48,070
+يعملّي impairment لإنسلين actionوهنا في عندنا
+
+375
+00:33:48,070 --> 00:33:52,910
+أمثلة على أدوية اللي بتعمل Beta cell dysfunction
+
+376
+00:33:52,910 --> 00:33:57,110
+زي الـ Dilantin اللي هو عبارة عن antiepileptic
+
+377
+00:33:57,110 --> 00:34:01,110
+drug اللي هو علاج بيعتلى الناس اللي عندهم اللي هو
+
+378
+00:34:01,110 --> 00:34:06,950
+تشنجات أو صرع وفي عندنا البنتاميدين antifungal
+
+379
+00:34:06,950 --> 00:34:12,370
+drug يبقى بعض الأدوية بتأثر على الـ Beta cell
+
+380
+00:34:12,370 --> 00:34:17,500
+functionوبالتالي بتخلل من ال release of insulin
+
+381
+00:34:17,500 --> 00:34:23,220
+أدوية أخرى impair insulin action بتأثر على عمل ال
+
+382
+00:34:23,220 --> 00:34:26,160
+insulin زي ال glucocorticoids
+
+383
+00:34:28,990 --> 00:34:33,830
+الو الكورتزول زي أن الفازايد لأدوية عبارة عن
+
+384
+00:34:33,830 --> 00:34:36,790
+diuretics اللي هي الأدوية المدررة للبول اللي بتعطى
+
+385
+00:34:36,790 --> 00:34:42,570
+للأشخاص اللي عندهم hypertension ارتفاع في ضغط الدم
+
+386
+00:34:42,570 --> 00:34:49,130
+و أيضا أن ال beta-adrenergics
+
+387
+00:34:50,880 --> 00:34:56,220
+اللي بتعطى لي المرضى اللي عندهم ضيق في التنفس أو
+
+388
+00:34:56,220 --> 00:35:02,280
+رابو يبقى أدوية مختلفة ممكن تأثر سواء على الـ beta
+
+389
+00:35:02,280 --> 00:35:07,380
+cell function أو تعمل impairment للـinsulin action
+
+390
+00:35:07,380 --> 00:35:13,680
+أيضًا ال infections برضه ممكن تأثر على عمل
+
+391
+00:35:13,680 --> 00:35:17,440
+البنكرياز ده كان صرفيا عندنا ممكن اللي هو التهاب
+
+392
+00:35:17,440 --> 00:35:22,750
+في البنكريازبرضه عندنا genetic conditions مختلفة
+
+393
+00:35:22,750 --> 00:35:29,310
+برضه ممكن تكون سبب في ارتفاع مستوى السكر في الدم
+
+394
+00:35:29,310 --> 00:35:32,530
+او الجلوكوز يعني زي الـ Down Syndrome أو Client
+
+395
+00:35:32,530 --> 00:35:41,510
+Filter Syndrome وطبعا هذا مرتبط بالزيادة الوزن عند
+
+396
+00:35:41,510 --> 00:35:47,010
+هدول البرضة due to high prevalence of obesity أيضا
+
+397
+00:35:47,010 --> 00:35:54,510
+عندنا الـ Porphyriaهذا بيؤدى الى وزيادة ال insulin
+
+398
+00:35:54,510 --> 00:36:00,910
+resistance وبالتالي ارتفاع مستوى الجلوكوز في الدم
+
+399
+00:36:00,910 --> 00:36:07,370
+عند هدول المرضى النوع الرابع والاخير ان ال
+
+400
+00:36:07,370 --> 00:36:11,490
+gestational diabetes mellitus اللى سكري الحمل
+
+401
+00:36:11,490 --> 00:36:17,100
+defined asAny degree of glucose intolerance with
+
+402
+00:36:17,100 --> 00:36:21,940
+onset or first recognition during pregnancy يهان
+
+403
+00:36:21,940 --> 00:36:29,560
+بيصير في عنا glucose intolerance بيبطل الجسم قادر
+
+404
+00:36:29,560 --> 00:36:33,400
+على التعامل مع ال glucose اللي هو بشكل صحيح و
+
+405
+00:36:33,400 --> 00:36:37,060
+بيصير في عنا بعض ال insulin resistance وبالتالي
+
+406
+00:36:37,060 --> 00:36:42,020
+هذا بيقدي الى ارتفاع في مستوى ال glucose في الدم
+
+407
+00:36:43,890 --> 00:36:47,150
+Estimates of the frequency of abnormal glucose
+
+408
+00:36:47,150 --> 00:36:51,670
+tolerance during pregnancy range from less than 1%
+
+409
+00:36:51,670 --> 00:36:56,310
+to 28% depending on the population studied and the
+
+410
+00:36:56,310 --> 00:37:01,210
+diagnostic tests employed.بعنا نسب ال gestational
+
+411
+00:37:01,210 --> 00:37:06,910
+diabetes ماليتس تختلفيعني حسب ال population و
+
+412
+00:37:06,910 --> 00:37:11,450
+الدراسات المختلفة في البلاد المختلفة يعني بتبين
+
+413
+00:37:11,450 --> 00:37:17,290
+هذا اللي اللي هو الفرق بين الحالات يعني في بعض
+
+414
+00:37:17,290 --> 00:37:20,630
+البلاد زي اللي ممكن اللي هو الدول الأوروبية ممكن
+
+415
+00:37:20,630 --> 00:37:25,350
+تكون النسب قليلة لكن ممكن في بلاد أخرى زي أفريقيا
+
+416
+00:37:25,350 --> 00:37:30,530
+عندنا النسب تكون أكبر prevalence of gestational
+
+417
+00:37:30,530 --> 00:37:34,430
+diabetes mellitus is increasingat least in part
+
+418
+00:37:34,430 --> 00:37:39,750
+due to the considerable increase in obesity بكمان
+
+419
+00:37:39,750 --> 00:37:44,690
+في أن التوجه أو في أننا يعني زيادة في حالات ال
+
+420
+00:37:44,690 --> 00:37:48,850
+gestational diabetes mellitus وهذا مرتبط برضه في
+
+421
+00:37:48,850 --> 00:37:52,890
+الزيادة في الأوزان و ال obesity
+
+422
+00:37:56,400 --> 00:38:01,380
+طبعا المشكلة أنه النساء اللي بيصابوا بال
+
+423
+00:38:01,380 --> 00:38:05,680
+gestational diabetes mellitus هم أكثر عرضة مستقبلا
+
+424
+00:38:05,680 --> 00:38:10,760
+للإصابة بال type 2 diabetes mellitus يعني هو ال ..
+
+425
+00:38:10,760 --> 00:38:13,240
+ال .. ال .. ال set بيجيها بإلحام ال gestational
+
+426
+00:38:13,240 --> 00:38:17,480
+diabetes mellitus بعد الولادة بترجع مستويات ال
+
+427
+00:38:17,480 --> 00:38:22,310
+glucose إلى الطبيعيطبعاً زي ما قلنا المشكلة أنه في
+
+428
+00:38:22,310 --> 00:38:26,590
+عندنا Insulin Resistance وعندنا الارتفاع في
+
+429
+00:38:26,590 --> 00:38:32,470
+الهرمونات أثناء الحمل، هذا بيلعب دور برضه في الـ
+
+430
+00:38:32,470 --> 00:38:38,770
+Insulin Resistance بعد الولادة بترجع الأمور
+
+431
+00:38:38,770 --> 00:38:44,730
+طبيعية، لكن هذا ال .. هدول النساء أكثر عرضة
+
+432
+00:38:44,730 --> 00:38:50,930
+للإصابة مستقبلا بـ Type 2 Diabetes Mellitusو يحدث
+
+433
+00:38:50,930 --> 00:38:57,410
+في 15% إلى 60% منهم، يعني نسبة مش بسيطة ممكن
+
+434
+00:38:57,410 --> 00:39:04,670
+يصابوا مستقبلا بالـ Type 2 Diabetes Malitus الخطر
+
+435
+00:39:04,670 --> 00:39:10,050
+خصيصًا عالي في المرأة اللي ماركت Hyperglycemia
+
+436
+00:39:10,050 --> 00:39:16,190
+خلال أو قريبًا بعد الفترةوكمان ال risk بتزيد عند
+
+437
+00:39:16,190 --> 00:39:19,930
+اللي هو بعض النساء وهذه اللي هي الخصائص اللي بتزيد
+
+438
+00:39:19,930 --> 00:39:23,430
+لإنساء اللي بتزيد عندهم فرصة الإصابة بـtype 2
+
+439
+00:39:23,430 --> 00:39:26,810
+diabetes mellitus مارت hyperglycemia during أو
+
+440
+00:39:26,810 --> 00:39:31,410
+soon after pregnancy يعني أننا ارتفاع بشكل كبير
+
+441
+00:39:31,410 --> 00:39:38,130
+بالجلوكوز اللي هو أثناء الحمل و اللي هو ممكن بعد
+
+442
+00:39:38,130 --> 00:39:43,050
+الولادة women who are obeseوعنا woman whose
+
+443
+00:39:43,050 --> 00:39:45,510
+gestation was a bit smalletus was diagnosed before
+
+444
+00:39:45,510 --> 00:39:50,560
+24 weeks gestationيعني عادة الفحص بيعمل عشان نشوف
+
+445
+00:39:50,560 --> 00:39:54,500
+إذا كان فيه a gestational diabetes mellitus اللي
+
+446
+00:39:54,500 --> 00:39:58,640
+هو بعد الأسبوع الأربع وعشرين وبالتالي إذا كان تم
+
+447
+00:39:58,640 --> 00:40:03,000
+اكتشاف إنه الست عند ارتفاع فيه مساوي الجلوكوز قبل
+
+448
+00:40:03,000 --> 00:40:06,380
+الأسبوع الأربع وعشرين يبقى برضه هذا تعتبر high
+
+449
+00:40:06,380 --> 00:40:11,300
+risk لهذه الست للإصابة مستقبلا بـtype 2 diabetes
+
+450
+00:40:11,300 --> 00:40:12,140
+mellitus
+
+451
+00:40:14,370 --> 00:40:17,490
+At 6 to 12 weeks of postpartum, all patients who
+
+452
+00:40:17,490 --> 00:40:19,590
+had gestational diabetes mellitus should be
+
+453
+00:40:19,590 --> 00:40:24,990
+evaluated بيه دول النساء اللي بيبين عندهم أو يعني
+
+454
+00:40:24,990 --> 00:40:28,890
+بتم تشخيصهم على أن عندهم gestational diabetes
+
+455
+00:40:28,890 --> 00:40:34,210
+mellitus لابد أن يصير فيه اللي هم متابع وعادة اللي
+
+456
+00:40:34,210 --> 00:40:39,410
+هو بعد 6 إلى 12 أسبوعلازم يصير في عندنا تقييم
+
+457
+00:40:39,410 --> 00:40:47,170
+لهدول ال .. ال .. البرضة ونرجع نعملهم oral glucose
+
+458
+00:40:47,170 --> 00:40:48,910
+tolerance test
+
+459
+00:40:51,380 --> 00:40:55,500
+إذا لم يكن الـ Diabetes موجودًا، يجب أن يتم تجاربه
+
+460
+00:40:55,500 --> 00:40:59,360
+على الـ Diabetes على الأقل كل ثلاثة سنة. بنسيبهمش،
+
+461
+00:40:59,360 --> 00:41:04,180
+ولابد إنه يظل فيه عندنا متابع لهدول المرضى، لأنه
+
+462
+00:41:04,180 --> 00:41:07,800
+زي ما قلنا إن هدول at higher risk لإصابة بـtype 2
+
+463
+00:41:07,800 --> 00:41:11,320
+diabetes mellitus وبالتالي يعني يظل في عندنا
+
+464
+00:41:11,320 --> 00:41:14,680
+متابع، عشان لو صار في عندهم المرض يتم اكتشافه
+
+465
+00:41:14,680 --> 00:41:21,390
+مباشرة ويتم التعامل مع المرضةبشكل سريع قبل ما تبدأ
+
+466
+00:41:21,390 --> 00:41:25,670
+عندنا ال complications المختلفة
+
diff --git a/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/bESKTB5yKZs_raw.json b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/bESKTB5yKZs_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..64f14a4463720d76e399013625ccf2739de9bc7d
--- /dev/null
+++ b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/bESKTB5yKZs_raw.json
@@ -0,0 +1 @@
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"no_speech_prob": 1.3113021850585938e-06, "words": [{"start": 617.22, "end": 617.56, "word": "في", "probability": 0.95166015625}, {"start": 617.56, "end": 618.36, "word": " 2019", "probability": 0.7880859375}, {"start": 618.36, "end": 620.3, "word": " العدد", "probability": 0.8470052083333334}, {"start": 620.3, "end": 620.82, "word": " وصل", "probability": 0.986572265625}, {"start": 620.82, "end": 621.22, "word": " لـ", "probability": 0.72265625}, {"start": 621.22, "end": 623.52, "word": " 463", "probability": 0.915771484375}, {"start": 623.52, "end": 625.82, "word": " مليون", "probability": 0.9879557291666666}, {"start": 625.82, "end": 628.46, "word": " 463", "probability": 0.60565185546875}, {"start": 628.46, "end": 628.92, "word": " مليون", "probability": 0.9943033854166666}, {"start": 628.92, "end": 629.24, "word": " يبقى", "probability": 0.9407958984375}, {"start": 629.24, "end": 629.92, "word": " بالـ", "probability": 0.751220703125}, {"start": 629.92, "end": 630.84, "word": " 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مستويات ال insulin تبدأ بالانخفاض وزي ما قلنا اللي هو في يعني مراحل متقدمة ممكن يبدأ المريض ال type 2 اللي هو يعتمد على اللي هو ال insulin الخارجي", "tokens": [40228, 22653, 16472, 3224, 26108, 32239, 3224, 29739, 1863, 4117, 16572, 32277, 46599, 6027, 2655, 6027, 1829, 3714, 43020, 6055, 44510, 10721, 39182, 39896, 4117, 32239, 3224, 3714, 14851, 45865, 9307, 2423, 21587, 6055, 44510, 10721, 20666, 7649, 9778, 5172, 46958, 4032, 11622, 1829, 19446, 12174, 1211, 8315, 13672, 1829, 31439, 8978, 37495, 22653, 3714, 23557, 5016, 1211, 44650, 28543, 46007, 3714, 43020, 7251, 44510, 10721, 9673, 16572, 11242, 2423, 2010, 568, 13672, 1829, 31439, 7251, 34268, 2304, 3215, 15844, 13672, 1829, 31439, 2423, 21587, 33962, 9640, 7435, 1829], "avg_logprob": -0.12699652512868245, "compression_ratio": 1.7704081632653061, "no_speech_prob": 1.7881393432617188e-07, "words": [{"start": 1508.66, "end": 1509.28, "word": "يعني", "probability": 0.969970703125}, {"start": 1509.28, "end": 1510.04, "word": " 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"end": 2066.16, "text": "وبالتالي بتخلل من ال release of insulin أدوية أخرى impair insulin action بتأثر على عمل ال insulin زي ال glucocorticoids", "tokens": [37746, 6027, 2655, 6027, 1829, 39894, 9778, 1211, 1211, 9154, 2423, 4374, 295, 21587, 5551, 3215, 2407, 10632, 5551, 34740, 7578, 30256, 21587, 3069, 39894, 10721, 49115, 15844, 6225, 42213, 2423, 21587, 30767, 1829, 2423, 1563, 1311, 905, 477, 2789, 3742], "avg_logprob": -0.12695312393563135, "compression_ratio": 1.265625, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 2053.9, "end": 2054.62, "word": "وبالتالي", "probability": 0.966015625}, {"start": 2054.62, "end": 2055.42, "word": " بتخلل", "probability": 0.7244873046875}, {"start": 2055.42, "end": 2055.8, "word": " من", "probability": 0.98974609375}, {"start": 2055.8, "end": 2056.18, "word": " ال", "probability": 0.93798828125}, {"start": 2056.18, "end": 2056.66, "word": " release", "probability": 0.81591796875}, {"start": 2056.66, "end": 2056.94, "word": " of", 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"end": 2202.02, "text": "Any degree of glucose intolerance with onset or first recognition during pregnancy يهان بيصير في عنا glucose intolerance بيبطل الجسم قادر على التعامل مع ال glucose اللي هو بشكل صحيح و بيصير في عنا بعض ال insulin resistance وبالتالي هذا بيقدي الى ارتفاع في مستوى ال glucose في الدم", "tokens": [29647, 4314, 295, 23997, 35278, 719, 365, 34948, 420, 700, 11150, 1830, 16120, 7251, 3224, 7649, 4724, 1829, 9381, 13546, 8978, 6225, 8315, 23997, 35278, 719, 4724, 1829, 3555, 9566, 1211, 25724, 38251, 12174, 18513, 2288, 15844, 16712, 3615, 10943, 1211, 20449, 2423, 23997, 13672, 1829, 31439, 4724, 8592, 28820, 20328, 5016, 1829, 5016, 4032, 4724, 1829, 9381, 13546, 8978, 6225, 8315, 45030, 11242, 2423, 21587, 7335, 46599, 6027, 2655, 6027, 1829, 23758, 4724, 1829, 4587, 16254, 2423, 7578, 1975, 43500, 5172, 45761, 8978, 3714, 14851, 2407, 7578, 2423, 23997, 8978, 32748, 2304], "avg_logprob": -0.14112366831049006, "compression_ratio": 1.6540084388185654, 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2475.92, "end": 2476.64, "word": " ويتم", "probability": 0.7252604166666666}, {"start": 2476.64, "end": 2477.86, "word": " التعامل", "probability": 0.9962158203125}, {"start": 2477.86, "end": 2478.32, "word": " مع", "probability": 0.9921875}, {"start": 2478.32, "end": 2479.18, "word": " المرضة", "probability": 0.88134765625}], "temperature": 1.0}, {"id": 105, "seek": 248567, "start": 2479.49, "end": 2485.67, "text": "بشكل سريع قبل ما تبدأ عندنا ال complications المختلفة", "tokens": [3555, 8592, 28820, 8608, 16572, 3615, 12174, 36150, 19446, 6055, 44510, 10721, 43242, 8315, 2423, 26566, 9673, 46456, 46538, 3660], "avg_logprob": -0.12602306547619047, "compression_ratio": 0.9770114942528736, "no_speech_prob": 0.0, "words": [{"start": 2479.49, "end": 2480.21, "word": "بشكل", "probability": 0.9890950520833334}, {"start": 2480.21, "end": 2480.59, "word": " سريع", "probability": 0.9835611979166666}, {"start": 2480.59, "end": 2480.83, "word": " قبل", "probability": 0.661865234375}, {"start": 2480.83, "end": 2480.97, "word": " ما", "probability": 0.81298828125}, {"start": 2480.97, "end": 2481.39, "word": " تبدأ", "probability": 0.919921875}, {"start": 2481.39, "end": 2481.97, "word": " عندنا", "probability": 0.75390625}, {"start": 2481.97, "end": 2482.63, "word": " ال", "probability": 0.98095703125}, {"start": 2482.63, "end": 2483.49, "word": " complications", "probability": 0.96923828125}, {"start": 2483.49, "end": 2485.67, "word": " المختلفة", "probability": 0.9896240234375}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2489.991875, "duration_after_vad": 2344.193124999991}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/bESKTB5yKZs_raw.srt b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/bESKTB5yKZs_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..3cead7f77dca85a4e1065a56db03d2aa9b7647b0
--- /dev/null
+++ b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/bESKTB5yKZs_raw.srt
@@ -0,0 +1,1864 @@
+1
+00:00:02,060 --> 00:00:05,600
+بسم الله الرحمن الرحيم والصلاة والسلام على خاتم
+
+2
+00:00:05,600 --> 00:00:09,280
+الأنبياء والمرسلين سيدنا محمد عليه الصلاة وأفضل
+
+3
+00:00:09,280 --> 00:00:16,960
+التسليميسعدني أن أكون معكم في مساق clinical
+
+4
+00:00:16,960 --> 00:00:23,120
+biochemistry أو كيمياء حيوية سريرية واللي ان شاء
+
+5
+00:00:23,120 --> 00:00:28,380
+الله سندرس من خلالها بعض الموضوعات التي تتعلق
+
+6
+00:00:28,380 --> 00:00:33,100
+بالكيمياء السريرية بيعني
+
+7
+00:00:33,100 --> 00:00:40,350
+تفاصيل أكتر يعني more advancedمقارنة بالدراسة اللي
+
+8
+00:00:40,350 --> 00:00:45,610
+دراستوها في ال baccalaureate تم تنزيل ال course
+
+9
+00:00:45,610 --> 00:00:51,970
+outline على صفحة ال model الموضوعات اللي سنتطرق
+
+10
+00:00:51,970 --> 00:00:58,470
+لها ان شاء الله من خلال دراستنا لهذا المساق سنبدأ
+
+11
+00:00:58,470 --> 00:01:04,410
+بال diabetes mellitus و بعد هيك هيكون في عندنا ال
+
+12
+00:01:04,410 --> 00:01:09,680
+cardiac functionطبعا زي ما قولنا يعني هنحكي بتفصيل
+
+13
+00:01:09,680 --> 00:01:13,280
+أكتر ليه
+
+14
+00:01:13,280 --> 00:01:17,680
+الأمراض المختلفة ممكن اللي بتصيب ال organs كيف
+
+15
+00:01:17,680 --> 00:01:25,120
+ممكن تشخيصها و هيكون دايما في نهاية المحاضرة في
+
+16
+00:01:25,120 --> 00:01:31,690
+بعض ال case studies اللي سنتطرق لهاعنا ايضا ال
+
+17
+00:01:31,690 --> 00:01:35,290
+kidney disease، في عنا ال disorders of water
+
+18
+00:01:35,290 --> 00:01:39,190
+electrolytes and acid base metabolism، liver
+
+19
+00:01:39,190 --> 00:01:43,370
+disease, gestric, pancreatic and intestinal
+
+20
+00:01:43,370 --> 00:01:48,800
+function و ال bone and mineral metabolismوإذا كان
+
+21
+00:01:48,800 --> 00:01:52,120
+ضال معانا وقت ان شاء الله هنشوف ال evidence-based
+
+22
+00:01:52,120 --> 00:01:57,500
+laboratory medicine هذه الموضوعات اللي هنتطرقلها
+
+23
+00:01:57,500 --> 00:02:04,500
+ان شاء الله من خلال دراستنا للمثقة طبعا
+
+24
+00:02:04,500 --> 00:02:08,280
+اللي بالنسبالنا توزيع الدرجات برضه موجود بال
+
+25
+00:02:08,280 --> 00:02:14,440
+course outline في عامة للفصل خمسة واربعين بالمية
+
+26
+00:02:15,250 --> 00:02:20,850
+عبارة عن تلاتين بالمية امتحان نصفي و هيكون فيه
+
+27
+00:02:20,850 --> 00:02:26,790
+presentation هتقدموها زي ما يعني حكيت التفاصيل على
+
+28
+00:02:26,790 --> 00:02:29,910
+مجموعة ال whatsapp هذا ال presentation عليها خمس
+
+29
+00:02:29,910 --> 00:02:33,710
+أعشر بالمية و الامتحان النهائي هيكون ان شاء الله
+
+30
+00:02:33,710 --> 00:02:40,350
+عليه خمسة و خمسين بالمية الموضوع
+
+31
+00:02:40,350 --> 00:02:44,090
+الأول اللي هنبدأ فيه هو ال diabetes malatus
+
+32
+00:02:47,990 --> 00:02:51,070
+الـ ده بيت اسمه الـ Letus group of metabolic
+
+33
+00:02:51,070 --> 00:02:57,030
+disorders يبقى مجموعة من ال disorders و اللي
+
+34
+00:02:57,030 --> 00:03:06,130
+بتشترك بخاصية و هي ارتفاع مستوى السكر في الدم يبقى
+
+35
+00:03:06,130 --> 00:03:11,210
+في عندنا hyperiglycemia خاصية مشتركة بين هذه ال
+
+36
+00:03:11,210 --> 00:03:17,080
+metabolic disordersوهذا الارتفاع بيه لـ Glucose
+
+37
+00:03:17,080 --> 00:03:24,480
+ناتج عن سبابينالسبب الأول ممكن يكون بسبب ال
+
+38
+00:03:24,480 --> 00:03:29,100
+defects in insulin secretion يكون في عندي مشكلة في
+
+39
+00:03:29,100 --> 00:03:35,200
+ال beta cells في ال pancreas اللي طبعا مسئولة عن
+
+40
+00:03:35,200 --> 00:03:38,920
+إنتاج ال insulin يمكن يكون في عندى مشكلة في ال
+
+41
+00:03:38,920 --> 00:03:42,040
+beta cells وبالتالي في عندي مشكلة في ال insulin
+
+42
+00:03:42,040 --> 00:03:47,260
+secretion أو ممكن يكون في عندي مشكلة في ال insulin
+
+43
+00:03:47,260 --> 00:03:53,140
+actionيبقى بيعمل ال insulin أو اللي هو ال
+
+44
+00:03:53,140 --> 00:03:58,580
+sensitivity of cells for insulin أو ممكن تكون
+
+45
+00:03:58,580 --> 00:04:04,540
+المشكلة بال insulin secretion و ال insulin action
+
+46
+00:04:04,540 --> 00:04:10,000
+وهذا اللي بيصير بحالات اللي هي الحالات المتقدمة من
+
+47
+00:04:10,000 --> 00:04:12,040
+ال type 2 diabetes mellitus
+
+48
+00:04:15,370 --> 00:04:20,670
+المرضى اللى بيصابه بـ Aldabeta Smellitus ممكن إذا
+
+49
+00:04:20,670 --> 00:04:25,670
+ارتفع مستوى السكر لمستويات أعلى من 600 milligram
+
+50
+00:04:25,670 --> 00:04:30,750
+per deciliter ممكن يعني يتعرضوا ل life threatening
+
+51
+00:04:30,750 --> 00:04:37,570
+conditions يمكن يكون حياتهم يعني مهددة في حال زى
+
+52
+00:04:37,570 --> 00:04:43,920
+ما اتفقنا أنه ارتفع مستوى الجلوكوز بشكل عاليو هذا
+
+53
+00:04:43,920 --> 00:04:50,220
+طبعا مرتبط بالـ ketoacidosis زي ما هنشوف و بالـ
+
+54
+00:04:50,220 --> 00:04:54,860
+hyperosmolar coma يبقى إذا كان ارتفع مستوى
+
+55
+00:04:54,860 --> 00:04:57,560
+الجلوكوز عن 600 milligram per deciliter طبعا ممكن
+
+56
+00:04:57,560 --> 00:05:03,100
+يرتفع لمستويات أعلى من هيك بكتير يبقى فيه أن بعض
+
+57
+00:05:03,100 --> 00:05:06,280
+المرضى حسب نوع السكر اللي عندهم ممكن يتعرضوا لـ
+
+58
+00:05:06,280 --> 00:05:13,370
+ketoacidosisاللي هي ممكن تصير فيه حموضة في الدم
+
+59
+00:05:13,370 --> 00:05:17,630
+وانخفاض في ال pH أو ممكن تصير فيه hyperosmolar
+
+60
+00:05:17,630 --> 00:05:24,030
+اللي هو coma اللي هو السبب الأساسي بيكون ال
+
+61
+00:05:24,030 --> 00:05:27,990
+dehydration اللي بيصير لدول المرضى
+
+62
+00:05:31,740 --> 00:05:37,700
+أيضا من ناحية أخرى ممكن يصير فيه انخفاض في مستوى
+
+63
+00:05:37,700 --> 00:05:40,860
+ال glucose بالدم وهذا برضه تعتبر life threatening
+
+64
+00:05:40,860 --> 00:05:46,480
+condition نصير في عندنا hypooglycemia برضه هذه
+
+65
+00:05:46,480 --> 00:05:52,540
+طبعا مشكلة لهدول المرضى وهذا ممكن طبعا يكون بسبب
+
+66
+00:05:52,540 --> 00:06:00,680
+العلاج يعني يكون في جرعة مثلا زيادة من ال insulin
+
+67
+00:06:01,390 --> 00:06:04,750
+أو يكون المريض أخذ الجرعه المناسبه لكن يكون بذل
+
+68
+00:06:04,750 --> 00:06:08,350
+مجهود أكبر على سبيل المثال، وجهة ده ممكن يؤدي الى
+
+69
+00:06:08,350 --> 00:06:14,410
+hypoglycemia واللي برضه طبعا أكيد يعتبر يعني مهدد
+
+70
+00:06:14,410 --> 00:06:19,710
+للحياة As
+
+71
+00:06:19,710 --> 00:06:23,070
+the disease progresses, patients are at increased
+
+72
+00:06:23,070 --> 00:06:26,050
+risk for the development of specific complications
+
+73
+00:06:26,870 --> 00:06:32,850
+بكمان ارتفاع الجلوكوز المستمر في الدم هذا هيؤدى
+
+74
+00:06:32,850 --> 00:06:37,230
+الى العديد من المشاكل المرضى العديد من ال
+
+75
+00:06:37,230 --> 00:06:41,950
+complications و هذه ال complications ممكن تكون
+
+76
+00:06:41,950 --> 00:06:48,380
+microvascular و ممكن تكون macrovascularالـ
+
+77
+00:06:48,380 --> 00:06:52,420
+Microvascular complications يعني عندنا أنثلة عديدة
+
+78
+00:06:52,420 --> 00:06:57,640
+زي اللي هو الـ Retinopathy تصير في عندنا مشكلة في
+
+79
+00:06:57,640 --> 00:07:03,700
+الشبكية و اللي ممكن تؤدي إلى العمى أيضًا ممكن تصير
+
+80
+00:07:03,700 --> 00:07:09,300
+في عندنا مشكلة بالـ Microviscles في ال kidney و
+
+81
+00:07:09,300 --> 00:07:12,820
+اللي ممكن تؤدي إلى Nephropathy و ممكن ينتهي المريض
+
+82
+00:07:12,820 --> 00:07:19,590
+بـ Renal Failureوعنا يعني عدد مش بسيط من ال ..
+
+83
+00:07:19,590 --> 00:07:27,700
+المرضى اللي عندهم renal failure هم مرضى سكريأيضا
+
+84
+00:07:27,700 --> 00:07:32,560
+الـ neuropathy برضه ممكن تصير في عنا مشكلة في ال
+
+85
+00:07:32,560 --> 00:07:36,780
+.. على مستوى الأعصاب و اللي ممكن تؤدي إلى nerve
+
+86
+00:07:36,780 --> 00:07:40,660
+damage يعني ال complications اللي مرتبطة بارتفاع
+
+87
+00:07:40,660 --> 00:07:44,020
+مستوى الجلوكوز في الدم عديدة زي ما قلنا
+
+88
+00:07:44,020 --> 00:07:47,300
+microvascular وفي عنا ال macrovascular
+
+89
+00:07:48,790 --> 00:07:53,890
+اللي هو في الـ atherosclerosis تصلب الشرايين و
+
+90
+00:07:53,890 --> 00:07:58,610
+طبعا اللي ال atherosclerosis تقدي إلى ضيق في
+
+91
+00:07:58,610 --> 00:08:03,170
+الأوعية الدموية في الشرايين و اللي ممكن ينتهي
+
+92
+00:08:03,170 --> 00:08:08,470
+الأمر بانسداد كامل للشريان و بالتالي المنطقة اللي
+
+93
+00:08:08,470 --> 00:08:14,270
+بيغضيها هذا الشريان هتنحرم من ال oxygen و طبعا
+
+94
+00:08:14,270 --> 00:08:23,470
+ممكن يعني يصير فينا موتلهذا الجزء يبقى ال
+
+95
+00:08:23,470 --> 00:08:27,450
+atherosclerosis حسب المشكلة في أي شريان موجود ممكن
+
+96
+00:08:27,450 --> 00:08:31,650
+هذا يؤدي إلى stroke إذا كان عندنا ال
+
+97
+00:08:31,650 --> 00:08:37,350
+atherosclerosis في ال arteries اللي بتغذي المخ
+
+98
+00:08:37,350 --> 00:08:41,590
+فيانا ممكن إذا كان صار في atherosclerosis بالشريان
+
+99
+00:08:41,590 --> 00:08:45,710
+اللي بتغذي الأطراف وصار في عندنا انستداد كامل هذا
+
+100
+00:08:45,710 --> 00:08:52,690
+ممكن يؤدي إلى gangreneوإذا كان عندنا الشريان اللي
+
+101
+00:08:52,690 --> 00:08:56,750
+فيه المشكلة هو اللي بيغذي عضلة القلب تمام في حالة
+
+102
+00:08:56,750 --> 00:08:59,710
+اللي بقول ان ال artery disease بيحدث ممكن يؤدي إلى
+
+103
+00:08:59,710 --> 00:09:04,610
+يعني موت جزء من عضلة القلب طبعا حسب اللي هو
+
+104
+00:09:04,610 --> 00:09:09,530
+الشريان اللي صار فيه عندنا اللي هو انسداد كامل
+
+105
+00:09:09,530 --> 00:09:13,750
+يبقى ال complications عديدة و أيضا خطيرة
+
+106
+00:09:18,750 --> 00:09:23,710
+طبعا مشكلة ال .. ال .. السكري او مرض السكري يعني
+
+107
+00:09:23,710 --> 00:09:30,110
+مشكلة كبيرة و المشكلة كل ما لها ايضا بيه ازدياد و
+
+108
+00:09:30,110 --> 00:09:36,570
+اعداد الناس اللي بتصاب بيه السكري بتزيد بشكل غير
+
+109
+00:09:36,570 --> 00:09:43,090
+اللي هو او اعلى من المتوقع دائما number of people
+
+110
+00:09:43,090 --> 00:09:46,050
+with diabetes has increased dramatically worldwide
+
+111
+00:09:47,910 --> 00:09:55,930
+عنا بيه الـ 2013 كان عدد المرضى 382 مليون ومتوقع
+
+112
+00:09:55,930 --> 00:10:03,990
+أنه يزيد العدد لـ 592 مليون هذا في العام 2035 يبقى
+
+113
+00:10:03,990 --> 00:10:09,250
+العدد كان بـ 2013 382 مليون وبناء على الحسابات
+
+114
+00:10:09,250 --> 00:10:14,410
+اللي عملوها اتوقعوا أنه بيه الـ 2035 يصير 592
+
+115
+00:10:14,410 --> 00:10:29,240
+مليونفي 2019 العدد وصل لـ 463 مليون 463 مليون يبقى
+
+116
+00:10:29,240 --> 00:10:34,140
+بالـ 2035 أكيد العدد هيكون أكبر بكتير من الوطن
+
+117
+00:10:34,140 --> 00:10:41,950
+توقعه في العام 2013 ويعني صار المتوقع بناء على
+
+118
+00:10:41,950 --> 00:10:49,230
+العدد المرضى في عام 2019 صار المتوقع أنه بالـ 2540
+
+119
+00:10:49,230 --> 00:10:55,190
+يصل العدد إلى 700 مليون مريض بالسكري
+
+120
+00:11:01,180 --> 00:11:04,260
+this number is predicted to reach 592 زي ما قولنا
+
+121
+00:11:04,260 --> 00:11:07,500
+في العام الفين و خمس و تلاتين eighty percent of
+
+122
+00:11:07,500 --> 00:11:11,220
+whom will live in low and middle income countries
+
+123
+00:11:11,220 --> 00:11:15,860
+يعني العدد الأكبر من المرضى هيكونوا موجودين في
+
+124
+00:11:15,860 --> 00:11:22,640
+اللي هي البلاد اللي مستوى الدخل فيها يعني منخفض أو
+
+125
+00:11:22,640 --> 00:11:29,720
+متوسطهذا الشكل بيوضح اللي هو توزيع الأعداد اللي ..
+
+126
+00:11:29,720 --> 00:11:34,500
+اللي هي الـ 382 اللي حكينا كانت بالـ 2013 على اللي
+
+127
+00:11:34,500 --> 00:11:38,800
+هي المناطق المختلفة أو القارات المختلفة ليه اللي
+
+128
+00:11:38,800 --> 00:11:43,840
+هو العالم وهو عندنا يعني مبين اللي .. اللي هو
+
+129
+00:11:43,840 --> 00:11:51,480
+عندنا الصين اللي هو أعلى عدد من المرضى اليومية
+
+130
+00:11:51,480 --> 00:11:53,580
+تمانية أو تلاتين مليون
+
+131
+00:11:55,680 --> 00:12:02,460
+المشكلة أيضًا إنه في عندنا نسبة من الناس مصابة
+
+132
+00:12:02,460 --> 00:12:08,760
+بمرض السكري لكن undiagnosed والمشكلة إنه هذا العدد
+
+133
+00:12:08,760 --> 00:12:14,620
+مش بسيط يعني إحنا لما بنحكي على 382 مليون شخص هدول
+
+134
+00:12:14,620 --> 00:12:19,210
+تم تشخيصهم إنهم مصابين بالـ diabetes mellitus
+
+135
+00:12:19,210 --> 00:12:27,530
+بالمقابل في عندنا 175 مليون هدول undiagnosed يبقى
+
+136
+00:12:27,530 --> 00:12:35,590
+دايما العدد فعليا الناس المصابة هو أكبر من الأرقام
+
+137
+00:12:35,590 --> 00:12:36,830
+المعلنة
+
+138
+00:12:38,600 --> 00:12:43,820
+ويعني هذه برضه مشكلة أنه مايتمش اكتشاف المرض بشكل
+
+139
+00:12:43,820 --> 00:12:50,300
+سريع وعادة يعني مرضى السكري ممكن يتم ال diagnosis
+
+140
+00:12:50,300 --> 00:12:56,820
+لهم ويكون فعليا بدت عندنا ال complications بالظهور
+
+141
+00:12:56,820 --> 00:13:00,640
+يبقى بيكون عندنا ال diagnosis صارت متأخرة بشكل
+
+142
+00:13:00,640 --> 00:13:01,700
+كبير
+
+143
+00:13:06,200 --> 00:13:09,480
+acute and chronic complications make diabetes the
+
+144
+00:13:09,480 --> 00:13:12,700
+fourth most common cause of death in the developed
+
+145
+00:13:12,700 --> 00:13:16,060
+world يبقى ال complications العديدة اللي حاكينا
+
+146
+00:13:16,060 --> 00:13:21,160
+عليها اللي هو سواء ال .. الارتفاع اللي .. اللي هو
+
+147
+00:13:21,160 --> 00:13:23,840
+مستوى ال glucose و ال life threatening conditions
+
+148
+00:13:23,840 --> 00:13:27,660
+اللي ممكن اللي هو تصير مع ال complications اللي هي
+
+149
+00:13:28,020 --> 00:13:31,860
+على مستوى ال micro vessels أو ال macro vessels هذه
+
+150
+00:13:31,860 --> 00:13:40,600
+بتؤدي إلى يعني موت مرضى السكري ويعتبر يعني الموت
+
+151
+00:13:40,600 --> 00:13:48,540
+من المرض الورابع سبب للموت in the developed world
+
+152
+00:13:53,890 --> 00:14:01,310
+Diabetes caused 5.1 million deaths in 2013 وهذا
+
+153
+00:14:01,310 --> 00:14:08,750
+اللي هو بيمثل يعني أن الشخص بيموت كل ست ثواني بسبب
+
+154
+00:14:08,750 --> 00:14:10,110
+مرض السكري
+
+155
+00:14:13,910 --> 00:14:18,910
+ال .. أيضًا ال .. المرض السكري و الرعاية اللى
+
+156
+00:14:18,910 --> 00:14:28,030
+بتقدمها الدول للمرضى برضه تكلفتها عالية جدًا تكلفت
+
+157
+00:14:28,030 --> 00:14:34,900
+اللى هو المتابعة للمرضى تكلفت العلاج تكلفتاللي هي
+
+158
+00:14:34,900 --> 00:14:40,240
+ال complications ودخول المستشفيات للهو الأسباب
+
+159
+00:14:40,240 --> 00:14:48,760
+المختلفة يبقى هذه التكلفة عالية والتكلفة بال 2013
+
+160
+00:14:48,760 --> 00:14:56,800
+كانت خمسمية تمانية واربعين billion دولار يبقى
+
+161
+00:14:59,050 --> 00:15:06,710
+548 مليار دولار هذه التكلفة ومتوقع أنه التكلفة
+
+162
+00:15:06,710 --> 00:15:15,070
+تزيد في العام 2035 لـ 627 مليار
+
+163
+00:15:15,070 --> 00:15:22,090
+دولار ولكن فعليا حسب الإحصائيات اللي عملوها بيه
+
+164
+00:15:22,090 --> 00:15:30,380
+الـ 2019 التكلفةعلى هذا اللي هو القطاع وصلت 760
+
+165
+00:15:30,380 --> 00:15:37,590
+مليار دولارزي ما قلنا إنه دايماً الأعداد يعني
+
+166
+00:15:37,590 --> 00:15:42,810
+بتفوق المتوقع وبالتالي أيضاً اللي هو التكلفة
+
+167
+00:15:42,810 --> 00:15:46,130
+وتكلفة تقديم الخدمة الصحية لهذه اللي هو الفئة من
+
+168
+00:15:46,130 --> 00:15:50,550
+المرضى برضه بتفوق المتوقع يعني هان وصلت كان متوقع
+
+169
+00:15:50,550 --> 00:15:58,850
+إنه بـ 2530 تصل 627 مليار بالـ 2019 وصلت 760 مليار
+
+170
+00:16:02,900 --> 00:16:05,260
+طيب بالنسبة لها ال classification of diabetes
+
+171
+00:16:05,260 --> 00:16:10,900
+mellitus ممكن نقسم ال diabetes mellitus إلى أربع
+
+172
+00:16:10,900 --> 00:16:15,680
+أقسام أساسية في عندنا ال type 1 diabetes وممكن
+
+173
+00:16:15,680 --> 00:16:19,840
+نقسمه إلى قسمين ال immune mediated و ال idiopathic
+
+174
+00:16:19,840 --> 00:16:22,560
+في عندنا ال type 2 diabetes في عندنا ال other
+
+175
+00:16:22,560 --> 00:16:26,800
+specific types وعندنا
+
+176
+00:16:26,800 --> 00:16:33,010
+ال gestational diabetes mellitusحنحكي شوية بتفصيل
+
+177
+00:16:33,010 --> 00:16:39,570
+عن هذه الأنواع المختلفة ونبدأ بالـ Type 1 Diabetes
+
+178
+00:16:39,570 --> 00:16:43,410
+Approximately
+
+179
+00:16:43,410 --> 00:16:47,250
+5% to 10% of all cases of diabetes mellitus يبقى 5
+
+180
+00:16:47,250 --> 00:16:52,570
+إلى 10% من مرضى السكر هم عبارة عن مرضى من النوع
+
+181
+00:16:52,570 --> 00:16:59,470
+الأولو هدول المرضى عادة بيكون عندنا ال .. ال ..
+
+182
+00:16:59,470 --> 00:17:04,970
+المشكلة اللي هي abrupt onset يعني مش زي ال type 2
+
+183
+00:17:04,970 --> 00:17:09,800
+ممكن المريض يقعد سنتين و تلاتةواللي هو عنده
+
+184
+00:17:09,800 --> 00:17:15,280
+المشكلة أو يعني عشان يصير تطور لهذه المشكلة وفيه
+
+185
+00:17:15,280 --> 00:17:18,740
+طبعا مرحلة اللي هو الـ Prediabetes لكن هان في الـ
+
+186
+00:17:18,740 --> 00:17:24,160
+Type 1 في عندنا abrupt onset يعني عندنا الفترة
+
+187
+00:17:24,160 --> 00:17:28,700
+اللي هي الظهور المرض يعني بتكون هي كانت زي فجأة
+
+188
+00:17:29,570 --> 00:17:34,090
+they have abrupt onset of symptoms اللي هو زي ال
+
+189
+00:17:34,090 --> 00:17:43,550
+polyuria polydipsia و ال weight loss they have
+
+190
+00:17:43,550 --> 00:17:49,310
+encephalopenia deficiency of insulin و زي ما احنا
+
+191
+00:17:49,310 --> 00:17:55,640
+عارفين انه ال type oneبصير في عنا المشكلة في ال
+
+192
+00:17:55,640 --> 00:18:00,220
+beta cells بصير في عنا destruction ل ال beta cells
+
+193
+00:18:00,220 --> 00:18:04,300
+الموجودة في ال islets of Langerhans في ال pancreas
+
+194
+00:18:04,300 --> 00:18:09,090
+وهي المسئولة طبعاعن إنتاج الإنسونين وإذا كان سر
+
+195
+00:18:09,090 --> 00:18:13,030
+فيانا destruction لهذه الخلايا اللي بتنتج
+
+196
+00:18:13,030 --> 00:18:18,510
+الإنسونين بيحصل فيانا انسروبينيا نقص شديد اللي هو
+
+197
+00:18:18,510 --> 00:18:22,710
+للإنسونين اللي ممكن يؤدي بالنهاية ل deficiency of
+
+198
+00:18:22,710 --> 00:18:27,530
+insulin dependent
+
+199
+00:18:27,530 --> 00:18:32,050
+on insulin to sustain life and prevent ketosisيبقى
+
+200
+00:18:32,050 --> 00:18:35,930
+مزال في عندنا absolute deficiency of insulin يبقى
+
+201
+00:18:35,930 --> 00:18:41,890
+هذا النوع من المرضى يبقى يعتمد اعتماد كامل على ال
+
+202
+00:18:41,890 --> 00:18:49,130
+insulin عشان يضلهم عايشين لازم يتم اعطائهم جرعات
+
+203
+00:18:49,130 --> 00:18:54,630
+من ال insulin يومياوعشان هيك كان اللي هو الاسم
+
+204
+00:18:54,630 --> 00:18:59,450
+السابق لـ Type 1 Diabetes كان Insulin Dependent
+
+205
+00:18:59,450 --> 00:19:03,990
+Diabetes Mellitus يبقى لابد من اللي هو أعطاهم
+
+206
+00:19:03,990 --> 00:19:10,390
+الإنسولين to sustain life وأيضا عشان نمنع حدوث الـ
+
+207
+00:19:10,390 --> 00:19:13,470
+Ketosis أو الـ Ketoacidosis
+
+208
+00:19:19,950 --> 00:19:23,930
+معظم المستخدمين لديها مخلوقات تشير إلى تجارب عملية
+
+209
+00:19:23,930 --> 00:19:25,710
+تجارب عملية
+
+210
+00:19:28,190 --> 00:19:31,270
+زي ما حكينا أنه الـ Type 1 ممكن اللي هو ينقسم إلى
+
+211
+00:19:31,270 --> 00:19:35,450
+قسمين، فينا الـ immune-mediated وفينا الـ
+
+212
+00:19:35,450 --> 00:19:39,270
+idiopathic، يبقى ما زال بحكي immune-mediated وطبعا
+
+213
+00:19:39,270 --> 00:19:43,450
+هذا اللي بيشكل النسبة الأكبر لاللي هو الـ Type 1
+
+214
+00:19:43,450 --> 00:19:45,770
+diabetes mellitus اللي هو النسبة الأكبر بيكون
+
+215
+00:19:45,770 --> 00:19:52,590
+immune-mediated يبقى ممكن يكون في عندنا antibodies
+
+216
+00:19:53,940 --> 00:19:57,760
+أو ممكن اللي هو تم الكشف عن antibodies عند هدول
+
+217
+00:19:57,760 --> 00:20:02,760
+المرضى Some
+
+218
+00:20:02,760 --> 00:20:05,400
+have no evidence of autoimmunity and are
+
+219
+00:20:05,400 --> 00:20:09,500
+classified as type 1-idiopathic وهذه اللي بتمثل
+
+220
+00:20:09,500 --> 00:20:14,780
+نسبة قليلة من مرضى الـtype 1 The big incidence
+
+221
+00:20:14,780 --> 00:20:20,610
+occurs in childhood and adolescenceوعشان هيك البعض
+
+222
+00:20:20,610 --> 00:20:24,730
+بيطلق عليه الواقع juvenile diabetes لأنه النسبة
+
+223
+00:20:24,730 --> 00:20:29,810
+الأكبر لالناس اللي بيوصابوا اللي بيكونوا أطفال
+
+224
+00:20:29,810 --> 00:20:33,870
+تقريبا 75% acquired the disease before the age of
+
+225
+00:20:33,870 --> 00:20:38,730
+18 but onset and the remainder may occur at any
+
+226
+00:20:38,730 --> 00:20:39,350
+age
+
+227
+00:20:43,770 --> 00:20:47,150
+النوع التاني اللي عندنا هو ال type 2 diabetes
+
+228
+00:20:47,150 --> 00:20:51,190
+mellitus طبعا ده بيمثل النسبة الأكبر من ال
+
+229
+00:20:51,190 --> 00:20:56,230
+diabetes mellitus اللي هو أكتر من 90% of all cases
+
+230
+00:20:56,230 --> 00:21:01,350
+of diabetes patients have minimal symptoms are not
+
+231
+00:21:01,350 --> 00:21:09,370
+prone to ketosis طبعا موضوع ال ketosis مرتبط بوجود
+
+232
+00:21:09,370 --> 00:21:16,190
+ال insulin أو عدم وجود ال insulinحكينا بيه الـ
+
+233
+00:21:16,190 --> 00:21:21,090
+Type 1 إنه مرضى الـ Type 1 بيتمدوا على الانسولين
+
+234
+00:21:21,090 --> 00:21:27,030
+to sustain life و زمون عشان نمنع الـ Ketosis لأن
+
+235
+00:21:27,030 --> 00:21:36,870
+عدم وجود الانسولين هذا يؤدي إلى زيادة بشكل كبير في
+
+236
+00:21:36,870 --> 00:21:38,590
+هرمون الـ glucagon
+
+237
+00:21:41,150 --> 00:21:44,270
+يبقى بزيد عندنا الجلوكاجون وبالتالي الجلوكاجون
+
+238
+00:21:44,270 --> 00:21:49,510
+بيزيد من الوالي glycogenolysis وبيزيد ايضا من
+
+239
+00:21:49,510 --> 00:21:54,950
+الجلوكونيوجينيسي نعم يبقى بزيد من الجلوكونيوجينيسي
+
+240
+00:21:54,950 --> 00:21:58,790
+وبالتالي بيزيد من اللي هو تصنيع ال carbohydrates
+
+241
+00:21:58,790 --> 00:22:03,570
+from non carbohydrate sources زي ال libids وهذا
+
+242
+00:22:03,570 --> 00:22:10,000
+بيؤدى الى إنتاج كميات كبيرة من ال ketone bodiesو
+
+243
+00:22:10,000 --> 00:22:14,900
+الـ ketone bodies اللي هو acidic و بيعملوا على خفض
+
+244
+00:22:14,900 --> 00:22:22,400
+ال pH للدم لكن
+
+245
+00:22:22,400 --> 00:22:29,050
+بال type 2 ال insulin موجودطبعا يبقى ما زال ال
+
+246
+00:22:29,050 --> 00:22:33,930
+insulin موجود يبقى ال insulin بيعمل inhibition على
+
+247
+00:22:33,930 --> 00:22:38,930
+ال ال alpha cells وبالتالي بيقلل او بيمنع من افراز
+
+248
+00:22:38,930 --> 00:22:44,450
+ال glucagon عشان
+
+249
+00:22:44,450 --> 00:22:47,390
+هيك بنقول ان ال patients have minimal symptoms و
+
+250
+00:22:47,390 --> 00:22:51,950
+are not prone to ketosis ليش they are not prone to
+
+251
+00:22:51,950 --> 00:22:54,810
+ketosis لأن ال insulin موجود
+
+252
+00:22:56,880 --> 00:23:01,680
+are not dependent on insulin to prevent ketonuria
+
+253
+00:23:01,680 --> 00:23:07,720
+يبقى بيعتمدوش على اللي هو ال insulin زي ما قلنا
+
+254
+00:23:07,720 --> 00:23:11,380
+لمنع اللي هو طبعا إنتاج ال ketone bodies اللي ممكن
+
+255
+00:23:11,380 --> 00:23:14,700
+تظهر بعد هيك طبعا في يعني تكون موجودة في الدم
+
+256
+00:23:14,700 --> 00:23:20,950
+وأيضا بتبدأ تظهر في ال urine لأن they are notاللي
+
+257
+00:23:20,950 --> 00:23:24,110
+هو insulin dependent وعشان ات كانوا زمان ال type 2
+
+258
+00:23:24,110 --> 00:23:28,330
+diabetes يسمى non-insulin dependent لكن طبعا تم
+
+259
+00:23:28,330 --> 00:23:32,150
+تغيير هذا الاسم لأنه لاجوا أنه المرضى من النوع
+
+260
+00:23:32,150 --> 00:23:37,570
+التاني ممكن في الحالات المتقدمة ممكن يصيروا
+
+261
+00:23:37,570 --> 00:23:43,200
+يعتمدوا على ال insulin يبقى في مراحل متقدمةمن
+
+262
+00:23:43,200 --> 00:23:48,240
+المرض ممكن يبدأ ال type 2 diabetes malatus patient
+
+263
+00:23:48,240 --> 00:23:53,640
+ممكن يبدأ ياخد insulin insulin
+
+264
+00:23:53,640 --> 00:23:57,500
+concentrations may be normal decreased or
+
+265
+00:23:57,500 --> 00:24:00,960
+increased and most people with this form of
+
+266
+00:24:00,960 --> 00:24:06,220
+diabetes have impaired insulin action يبقى لو
+
+267
+00:24:06,220 --> 00:24:10,390
+أجينا فحثنا مستويات ال insulinممكن نلاقي إنه
+
+268
+00:24:10,390 --> 00:24:17,510
+المستويات طبيعية أو نلاقي إنه المستويات أقل من
+
+269
+00:24:17,510 --> 00:24:25,810
+الطبيعي أو أكتر من الطبيعي طبعا في البداية يعني بس
+
+270
+00:24:25,810 --> 00:24:31,350
+تبدأ ترتفع أنه مستويات الجلوكوز الـ pancreas أكيد
+
+271
+00:24:31,350 --> 00:24:37,920
+بيبدأ يزيد من إنتاجه للإنسلينلأن دي يعمل ال
+
+272
+00:24:37,920 --> 00:24:42,560
+compensation لإن ال glucose زاد يبقى ال ال
+
+273
+00:24:42,560 --> 00:24:47,400
+pancreas بده يفرز أكتر insulin عشان يحافظ على
+
+274
+00:24:47,400 --> 00:24:52,940
+مستوى ال glucose ضمن ال reference intervalيعني
+
+275
+00:24:52,940 --> 00:24:56,700
+ممكن في البدايات تلاقي أنه ال .. الـ Glucose
+
+276
+00:24:56,700 --> 00:25:02,360
+الانسولين ال concentration ممكن تبدأ ترتفع لكن مع
+
+277
+00:25:02,360 --> 00:25:06,200
+الاستمرار في الارتفاع لمستوى الـ Glucose ممكن يبدأ
+
+278
+00:25:06,200 --> 00:25:11,160
+يصير في عنا اللي هويعني انهاج ليه البنكرياس
+
+279
+00:25:11,160 --> 00:25:17,100
+وبالتالي ممكن تبدأ بعد هيك ليه مستويات ال insulin
+
+280
+00:25:17,100 --> 00:25:23,000
+تبدأ بالانخفاض وزي ما قلنا اللي هو في يعني مراحل
+
+281
+00:25:23,000 --> 00:25:28,780
+متقدمة ممكن يبدأ المريض ال type 2 اللي هو يعتمد
+
+282
+00:25:28,780 --> 00:25:32,040
+على اللي هو ال insulin الخارجي
+
+283
+00:25:36,520 --> 00:25:39,520
+طبعاً هذا انه زي ما قلنا انه فيه impaired insulin
+
+284
+00:25:39,520 --> 00:25:43,760
+action في عندنا هان مشكلة في عمل ال insulin في
+
+285
+00:25:43,760 --> 00:25:47,160
+عندنا ال sensitivity of cells to insulin اللي هو
+
+286
+00:25:47,160 --> 00:25:54,920
+أقل من الطبيعي وبالتالي بتحتاج إلى concentrations
+
+287
+00:25:54,920 --> 00:26:03,320
+أعلى من ال insulin عشان تقوم بالوظيفة المطلوبة ال
+
+288
+00:26:03,320 --> 00:26:10,310
+obesity بتلعبدور في ال type 2 diabetes مالليتاس
+
+289
+00:26:10,310 --> 00:26:16,390
+obesity is commonly associated ال ال ال obesity و
+
+290
+00:26:16,390 --> 00:26:19,030
+أيضا ال يعني في بعض الأشخاص اللي بيكونوا
+
+291
+00:26:19,030 --> 00:26:26,280
+overweight يبقى obese أو ممكن overweightوعشان هيك
+
+292
+00:26:26,280 --> 00:26:29,520
+ال weight loss alone usually improves
+
+293
+00:26:29,520 --> 00:26:34,000
+hyperglycemia يعني عادة اللي هو مرضى السكري
+
+294
+00:26:34,000 --> 00:26:38,900
+النصيحة الأولى اللي بوجهالهم الطبيب أنه لازم
+
+295
+00:26:38,900 --> 00:26:46,260
+ينزلوا وزنهم لو نزلوا وزنهم هذا ممكن يحسن من
+
+296
+00:26:46,260 --> 00:26:53,880
+مستويات ال glucose عندهموالناس اللي لسه في مرحلة
+
+297
+00:26:53,880 --> 00:26:58,960
+الـ Prediabetes لو نزلوا وزنهم، لعبوا رياضة، غيروا
+
+298
+00:26:58,960 --> 00:27:04,200
+نمط حياتهم، ممكن يعني أخرقوا بشكل كبير الإصابة
+
+299
+00:27:04,200 --> 00:27:09,660
+بالـ Type 2 However,
+
+300
+00:27:09,700 --> 00:27:12,700
+many individuals with Type 2 diabetes mellitus may
+
+301
+00:27:12,700 --> 00:27:16,220
+require dietary intervention, oral, anti
+
+302
+00:27:16,220 --> 00:27:20,090
+-hyperglycemic agentsor insulin to control
+
+303
+00:27:20,090 --> 00:27:25,630
+hyperglycemia طبعا
+
+304
+00:27:25,630 --> 00:27:30,570
+أول شغلة بيبدأ فيها الطبيب في حالة ال diagnosis
+
+305
+00:27:30,570 --> 00:27:34,590
+لشخص ب type 2 diabetes mellitus هو ال dietary
+
+306
+00:27:34,590 --> 00:27:42,230
+intervention يبقى لفترة إذا اتحسن مستوى ال glucose
+
+307
+00:27:42,230 --> 00:27:45,730
+ممكن اللي هو يستمروا ب اللي هو ال diet أو ال
+
+308
+00:27:45,730 --> 00:27:49,470
+dietary intervention لكنلو دال ال .. ال .. ال
+
+309
+00:27:49,470 --> 00:27:53,910
+glucose مرتفع بيبدأ لو بيعطاء الأدوية اللي هي ال
+
+310
+00:27:53,910 --> 00:27:58,610
+oral anti-hyperglycemic agents وزي ما قولنا في
+
+311
+00:27:58,610 --> 00:28:05,570
+مراحل متقدمة من المرض ممكن الطبي بيلجأ إلى ال
+
+312
+00:28:05,570 --> 00:28:09,470
+insulin most
+
+313
+00:28:09,470 --> 00:28:12,750
+patients acquired disease after age 40 got it may
+
+314
+00:28:12,750 --> 00:28:20,630
+occur in younger peopleيبقى زمان كان ال .. يعني
+
+315
+00:28:20,630 --> 00:28:26,890
+الناس اللي بيصابوا عادة بيكونوا فوق الأربعين لكن
+
+316
+00:28:26,890 --> 00:28:33,370
+الآن صار في أطفال بيصابوا ب ال type 2 diabetes
+
+317
+00:28:33,370 --> 00:28:39,190
+malitus طبعا هذا بيرجع ليه اللي هو نوع الطعام اللي
+
+318
+00:28:39,190 --> 00:28:45,480
+بنتناوله اللي هو الطعام الغير صحينمط الحياة اللي
+
+319
+00:28:45,480 --> 00:28:52,440
+بنعيشه اللي هو كله يعني خمول وفيش حركة وفيش رياضة
+
+320
+00:28:52,440 --> 00:28:59,300
+تمام و بالتالي هذا يعني أدى إلى انخفاض في العمر
+
+321
+00:28:59,300 --> 00:29:03,300
+للي اللي هو حدوث هذا المرض.
+
+322
+00:29:05,680 --> 00:29:08,620
+Type 2 diabetes mellitus في الأولواء والأطفال هو
+
+323
+00:29:08,620 --> 00:29:16,500
+مشكلة مهمة كثيرة زي ما قلنا هذا يعني مرتبط بالطعام
+
+324
+00:29:16,500 --> 00:29:25,000
+والحياة اللي بنعيشها حاليا among children in Japan
+
+325
+00:29:25,000 --> 00:29:28,480
+in 1998 Type 2 diabetes mellitus was more common
+
+326
+00:29:28,480 --> 00:29:33,340
+than Type 1 accounting for 80% of childhood
+
+327
+00:29:33,340 --> 00:29:40,110
+diabetesطبعا يبقى في ال 98 في اليابان كان نسبة
+
+328
+00:29:40,110 --> 00:29:47,330
+عالية من الأطفال مصابين بال type 2 diabetes و أكتر
+
+329
+00:29:47,330 --> 00:29:51,370
+طبعا من الأطفال اللي مصابين بيه اللي هو ال type 1
+
+330
+00:29:51,370 --> 00:29:54,330
+نحنا بيقولنا اللي هو ال type 1 عادة هو juvenile
+
+331
+00:29:54,330 --> 00:29:59,390
+لكن بسبب اللي هو زي ما قلنا الطعام و الحياةاللي
+
+332
+00:29:59,390 --> 00:30:05,530
+بعيش هذه الأطفال صار في إصابات عالية عندهم بالـ
+
+333
+00:30:05,530 --> 00:30:09,790
+Type 2 ال
+
+334
+00:30:09,790 --> 00:30:13,510
+class التالت specific types of diabetes mellitus
+
+335
+00:30:13,510 --> 00:30:18,750
+due to other causes يهان عندنا ال diabetes
+
+336
+00:30:18,750 --> 00:30:24,050
+mellitus أو الـ hyperglycemia هي secondary ل
+
+337
+00:30:24,050 --> 00:30:30,650
+primary diseaseما في عندنا مشكلة أساسية ونتيجة هذه
+
+338
+00:30:30,650 --> 00:30:35,810
+المشكلة صار في عندنا ارتفاع في الجلوكوز this
+
+339
+00:30:35,810 --> 00:30:38,610
+subclass includes uncommon patients in whom
+
+340
+00:30:38,610 --> 00:30:41,710
+hyperglycemia is due to a specific underlying
+
+341
+00:30:41,710 --> 00:30:46,330
+disorder إذا ما قولنا له secondary لا disorder أو
+
+342
+00:30:46,330 --> 00:30:54,570
+مشكلة موجودة وعندنا من الأسباب ال genetic defects
+
+343
+00:30:54,570 --> 00:30:59,730
+of beta cell functionواللي هو هذا النوع اللي بيطلق
+
+344
+00:30:59,730 --> 00:31:05,650
+عليه maturity onset the betas of the young يعني في
+
+345
+00:31:05,650 --> 00:31:11,710
+عندنا مشكلة بال beta cell function وبالتالي بيكون
+
+346
+00:31:11,710 --> 00:31:20,410
+في عندنا انخفاض في المستوى ال insulin genetic
+
+347
+00:31:20,410 --> 00:31:24,850
+defectsin insulin action ممكن يكون في عندنا
+
+348
+00:31:24,850 --> 00:31:28,550
+genetic defect في نفس الانسولين type A insulin
+
+349
+00:31:28,550 --> 00:31:31,930
+resistance syndrome due to insulin receptor gene
+
+350
+00:31:31,930 --> 00:31:39,190
+mutations المشكلة في ال receptor او mutation في ال
+
+351
+00:31:39,190 --> 00:31:43,450
+ال ال هو ال insulin receptor gene
+
+352
+00:31:46,790 --> 00:31:51,490
+برضه عندنا الأمراض اللى بتصيب ال pancreas برضه هذه
+
+353
+00:31:51,490 --> 00:31:58,170
+ممكن تؤدي إلى يعني انخفاض في ال release of insulin
+
+354
+00:31:58,170 --> 00:32:04,770
+زى ال cystic fibrosisأه زي ما انتوا عارفين اللي هو
+
+355
+00:32:04,770 --> 00:32:09,150
+ال .. هذا بيعمل viscous and mucous وبالتالي يعني
+
+356
+00:32:09,150 --> 00:32:15,710
+بيمنع من ال .. أو بيأثر يعني على وظيفة ال بنكرياس
+
+357
+00:32:15,710 --> 00:32:20,190
+بشكل عام وبالتالي بيقلل من ال release of insulin
+
+358
+00:32:20,190 --> 00:32:26,500
+أيضا فينا ال endocrinopathiesالمشكلات اللي متعلقة
+
+359
+00:32:26,500 --> 00:32:30,900
+بالأمراض الهرمونات زي في عندنا اللي هو الـ
+
+360
+00:32:30,900 --> 00:32:35,160
+Cauchin's Syndrome وهذا طبعا اللي بيقدّي إلى
+
+361
+00:32:35,160 --> 00:32:39,180
+ارتفاع في الكورتزول وزي ما انتوا عارفين الكورتزول
+
+362
+00:32:39,180 --> 00:32:45,800
+هو عبارة عن hyperglycemic agent بيعبر عن هرمون
+
+363
+00:32:45,800 --> 00:32:50,960
+اللي هو بيزيد من لمستويات الجلوكوز في الدم الـ
+
+364
+00:32:50,960 --> 00:32:57,070
+Acromegalyو يكون في عنا زيادة في الـ Growth
+
+365
+00:32:57,070 --> 00:32:58,910
+hormone والـ Growth hormone برضه بيعتبر
+
+366
+00:32:58,910 --> 00:33:05,820
+hyperglycemic agentو ال glycagonoma اللي هو عندنا
+
+367
+00:33:05,820 --> 00:33:10,900
+form of pancreatic cancer اللي بيصير فيه عندنا
+
+368
+00:33:10,900 --> 00:33:17,120
+إنتاج لكميات كبيرة من ال glycagon و برضه زي ما
+
+369
+00:33:17,120 --> 00:33:21,620
+انتوا عارفين ال glycagon هو عبارة عن hyperglycemic
+
+370
+00:33:21,620 --> 00:33:26,880
+agents من الهرمونات اللي بترفع مستويات ال glucose
+
+371
+00:33:26,880 --> 00:33:33,550
+في الدمإن أيضًا إعطاء المرضايا بعض ال .. الهرمونات
+
+372
+00:33:33,550 --> 00:33:40,370
+أو ممكن بعض الأدوية، هذا ممكن يأثر على الـ beta
+
+373
+00:33:40,370 --> 00:33:42,750
+cell function اللي هو على سبيل المثال أو ممكن
+
+374
+00:33:42,750 --> 00:33:48,070
+يعملّي impairment لإنسلين actionوهنا في عندنا
+
+375
+00:33:48,070 --> 00:33:52,910
+أمثلة على أدوية اللي بتعمل Beta cell dysfunction
+
+376
+00:33:52,910 --> 00:33:57,110
+زي الـ Dilantin اللي هو عبارة عن antiepileptic
+
+377
+00:33:57,110 --> 00:34:01,110
+drug اللي هو علاج بيعتلى الناس اللي عندهم اللي هو
+
+378
+00:34:01,110 --> 00:34:06,950
+تشنجات أو صرع وفي عندنا البنتاميدين antifungal
+
+379
+00:34:06,950 --> 00:34:12,370
+drug يبقى بعض الأدوية بتأثر على الـ Beta cell
+
+380
+00:34:12,370 --> 00:34:17,500
+functionوبالتالي بتخلل من ال release of insulin
+
+381
+00:34:17,500 --> 00:34:23,220
+أدوية أخرى impair insulin action بتأثر على عمل ال
+
+382
+00:34:23,220 --> 00:34:26,160
+insulin زي ال glucocorticoids
+
+383
+00:34:28,990 --> 00:34:33,830
+الو الكورتزول زي أن الفازايد لأدوية عبارة عن
+
+384
+00:34:33,830 --> 00:34:36,790
+diuretics اللي هي الأدوية المدررة للبول اللي بتعطى
+
+385
+00:34:36,790 --> 00:34:42,570
+للأشخاص اللي عندهم hypertension ارتفاع في ضغط الدم
+
+386
+00:34:42,570 --> 00:34:49,130
+و أيضا أن ال beta-adrenergics
+
+387
+00:34:50,880 --> 00:34:56,220
+اللي بتعطى لي المرضى اللي عندهم ضيق في التنفس أو
+
+388
+00:34:56,220 --> 00:35:02,280
+رابو يبقى أدوية مختلفة ممكن تأثر سواء على الـ beta
+
+389
+00:35:02,280 --> 00:35:07,380
+cell function أو تعمل impairment للـinsulin action
+
+390
+00:35:07,380 --> 00:35:13,680
+أيضًا ال infections برضه ممكن تأثر على عمل
+
+391
+00:35:13,680 --> 00:35:17,440
+البنكرياز ده كان صرفيا عندنا ممكن اللي هو التهاب
+
+392
+00:35:17,440 --> 00:35:22,750
+في البنكريازبرضه عندنا genetic conditions مختلفة
+
+393
+00:35:22,750 --> 00:35:29,310
+برضه ممكن تكون سبب في ارتفاع مستوى السكر في الدم
+
+394
+00:35:29,310 --> 00:35:32,530
+او الجلوكوز يعني زي الـ Down Syndrome أو Client
+
+395
+00:35:32,530 --> 00:35:41,510
+Filter Syndrome وطبعا هذا مرتبط بالزيادة الوزن عند
+
+396
+00:35:41,510 --> 00:35:47,010
+هدول البرضة due to high prevalence of obesity أيضا
+
+397
+00:35:47,010 --> 00:35:54,510
+عندنا الـ Porphyriaهذا بيؤدى الى وزيادة ال insulin
+
+398
+00:35:54,510 --> 00:36:00,910
+resistance وبالتالي ارتفاع مستوى الجلوكوز في الدم
+
+399
+00:36:00,910 --> 00:36:07,370
+عند هدول المرضى النوع الرابع والاخير ان ال
+
+400
+00:36:07,370 --> 00:36:11,490
+gestational diabetes mellitus اللى سكري الحمل
+
+401
+00:36:11,490 --> 00:36:17,100
+defined asAny degree of glucose intolerance with
+
+402
+00:36:17,100 --> 00:36:21,940
+onset or first recognition during pregnancy يهان
+
+403
+00:36:21,940 --> 00:36:29,560
+بيصير في عنا glucose intolerance بيبطل الجسم قادر
+
+404
+00:36:29,560 --> 00:36:33,400
+على التعامل مع ال glucose اللي هو بشكل صحيح و
+
+405
+00:36:33,400 --> 00:36:37,060
+بيصير في عنا بعض ال insulin resistance وبالتالي
+
+406
+00:36:37,060 --> 00:36:42,020
+هذا بيقدي الى ارتفاع في مستوى ال glucose في الدم
+
+407
+00:36:43,890 --> 00:36:47,150
+Estimates of the frequency of abnormal glucose
+
+408
+00:36:47,150 --> 00:36:51,670
+tolerance during pregnancy range from less than 1%
+
+409
+00:36:51,670 --> 00:36:56,310
+to 28% depending on the population studied and the
+
+410
+00:36:56,310 --> 00:37:01,210
+diagnostic tests employed.بعنا نسب ال gestational
+
+411
+00:37:01,210 --> 00:37:06,910
+diabetes ماليتس تختلفيعني حسب ال population و
+
+412
+00:37:06,910 --> 00:37:11,450
+الدراسات المختلفة في البلاد المختلفة يعني بتبين
+
+413
+00:37:11,450 --> 00:37:17,290
+هذا اللي اللي هو الفرق بين الحالات يعني في بعض
+
+414
+00:37:17,290 --> 00:37:20,630
+البلاد زي اللي ممكن اللي هو الدول الأوروبية ممكن
+
+415
+00:37:20,630 --> 00:37:25,350
+تكون النسب قليلة لكن ممكن في بلاد أخرى زي أفريقيا
+
+416
+00:37:25,350 --> 00:37:30,530
+عندنا النسب تكون أكبر prevalence of gestational
+
+417
+00:37:30,530 --> 00:37:34,430
+diabetes mellitus is increasingat least in part
+
+418
+00:37:34,430 --> 00:37:39,750
+due to the considerable increase in obesity بكمان
+
+419
+00:37:39,750 --> 00:37:44,690
+في أن التوجه أو في أننا يعني زيادة في حالات ال
+
+420
+00:37:44,690 --> 00:37:48,850
+gestational diabetes mellitus وهذا مرتبط برضه في
+
+421
+00:37:48,850 --> 00:37:52,890
+الزيادة في الأوزان و ال obesity
+
+422
+00:37:56,400 --> 00:38:01,380
+طبعا المشكلة أنه النساء اللي بيصابوا بال
+
+423
+00:38:01,380 --> 00:38:05,680
+gestational diabetes mellitus هم أكثر عرضة مستقبلا
+
+424
+00:38:05,680 --> 00:38:10,760
+للإصابة بال type 2 diabetes mellitus يعني هو ال ..
+
+425
+00:38:10,760 --> 00:38:13,240
+ال .. ال .. ال set بيجيها بإلحام ال gestational
+
+426
+00:38:13,240 --> 00:38:17,480
+diabetes mellitus بعد الولادة بترجع مستويات ال
+
+427
+00:38:17,480 --> 00:38:22,310
+glucose إلى الطبيعيطبعاً زي ما قلنا المشكلة أنه في
+
+428
+00:38:22,310 --> 00:38:26,590
+عندنا Insulin Resistance وعندنا الارتفاع في
+
+429
+00:38:26,590 --> 00:38:32,470
+الهرمونات أثناء الحمل، هذا بيلعب دور برضه في الـ
+
+430
+00:38:32,470 --> 00:38:38,770
+Insulin Resistance بعد الولادة بترجع الأمور
+
+431
+00:38:38,770 --> 00:38:44,730
+طبيعية، لكن هذا ال .. هدول النساء أكثر عرضة
+
+432
+00:38:44,730 --> 00:38:50,930
+للإصابة مستقبلا بـ Type 2 Diabetes Mellitusو يحدث
+
+433
+00:38:50,930 --> 00:38:57,410
+في 15% إلى 60% منهم، يعني نسبة مش بسيطة ممكن
+
+434
+00:38:57,410 --> 00:39:04,670
+يصابوا مستقبلا بالـ Type 2 Diabetes Malitus الخطر
+
+435
+00:39:04,670 --> 00:39:10,050
+خصيصًا عالي في المرأة اللي ماركت Hyperglycemia
+
+436
+00:39:10,050 --> 00:39:16,190
+خلال أو قريبًا بعد الفترةوكمان ال risk بتزيد عند
+
+437
+00:39:16,190 --> 00:39:19,930
+اللي هو بعض النساء وهذه اللي هي الخصائص اللي بتزيد
+
+438
+00:39:19,930 --> 00:39:23,430
+لإنساء اللي بتزيد عندهم فرصة الإصابة بـtype 2
+
+439
+00:39:23,430 --> 00:39:26,810
+diabetes mellitus مارت hyperglycemia during أو
+
+440
+00:39:26,810 --> 00:39:31,410
+soon after pregnancy يعني أننا ارتفاع بشكل كبير
+
+441
+00:39:31,410 --> 00:39:38,130
+بالجلوكوز اللي هو أثناء الحمل و اللي هو ممكن بعد
+
+442
+00:39:38,130 --> 00:39:43,050
+الولادة women who are obeseوعنا woman whose
+
+443
+00:39:43,050 --> 00:39:45,510
+gestation was a bit smalletus was diagnosed before
+
+444
+00:39:45,510 --> 00:39:50,560
+24 weeks gestationيعني عادة الفحص بيعمل عشان نشوف
+
+445
+00:39:50,560 --> 00:39:54,500
+إذا كان فيه a gestational diabetes mellitus اللي
+
+446
+00:39:54,500 --> 00:39:58,640
+هو بعد الأسبوع الأربع وعشرين وبالتالي إذا كان تم
+
+447
+00:39:58,640 --> 00:40:03,000
+اكتشاف إنه الست عند ارتفاع فيه مساوي الجلوكوز قبل
+
+448
+00:40:03,000 --> 00:40:06,380
+الأسبوع الأربع وعشرين يبقى برضه هذا تعتبر high
+
+449
+00:40:06,380 --> 00:40:11,300
+risk لهذه الست للإصابة مستقبلا بـtype 2 diabetes
+
+450
+00:40:11,300 --> 00:40:12,140
+mellitus
+
+451
+00:40:14,370 --> 00:40:17,490
+At 6 to 12 weeks of postpartum, all patients who
+
+452
+00:40:17,490 --> 00:40:19,590
+had gestational diabetes mellitus should be
+
+453
+00:40:19,590 --> 00:40:24,990
+evaluated بيه دول النساء اللي بيبين عندهم أو يعني
+
+454
+00:40:24,990 --> 00:40:28,890
+بتم تشخيصهم على أن عندهم gestational diabetes
+
+455
+00:40:28,890 --> 00:40:34,210
+mellitus لابد أن يصير فيه اللي هم متابع وعادة اللي
+
+456
+00:40:34,210 --> 00:40:39,410
+هو بعد 6 إلى 12 أسبوعلازم يصير في عندنا تقييم
+
+457
+00:40:39,410 --> 00:40:47,170
+لهدول ال .. ال .. البرضة ونرجع نعملهم oral glucose
+
+458
+00:40:47,170 --> 00:40:48,910
+tolerance test
+
+459
+00:40:51,380 --> 00:40:55,500
+إذا لم يكن الـ Diabetes موجودًا، يجب أن يتم تجاربه
+
+460
+00:40:55,500 --> 00:40:59,360
+على الـ Diabetes على الأقل كل ثلاثة سنة. بنسيبهمش،
+
+461
+00:40:59,360 --> 00:41:04,180
+ولابد إنه يظل فيه عندنا متابع لهدول المرضى، لأنه
+
+462
+00:41:04,180 --> 00:41:07,800
+زي ما قلنا إن هدول at higher risk لإصابة بـtype 2
+
+463
+00:41:07,800 --> 00:41:11,320
+diabetes mellitus وبالتالي يعني يظل في عندنا
+
+464
+00:41:11,320 --> 00:41:14,680
+متابع، عشان لو صار في عندهم المرض يتم اكتشافه
+
+465
+00:41:14,680 --> 00:41:21,390
+مباشرة ويتم التعامل مع المرضةبشكل سريع قبل ما تبدأ
+
+466
+00:41:21,390 --> 00:41:25,670
+عندنا ال complications المختلفة
+
diff --git a/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/pTZfQgG5v8w.srt b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/pTZfQgG5v8w.srt
new file mode 100644
index 0000000000000000000000000000000000000000..f72370c33cdcdd009429aef47758d74b9cddd81b
--- /dev/null
+++ b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/pTZfQgG5v8w.srt
@@ -0,0 +1,1854 @@
+1
+00:00:02,160 --> 00:00:06,640
+Ten-year-old male presented to the emergency
+
+2
+00:00:06,640 --> 00:00:12,740
+department with recent history of polydipsia يبقى
+
+3
+00:00:12,740 --> 00:00:19,500
+طفل عمره عشر سنين ودخل اللي هو الاستقبال في
+
+4
+00:00:19,500 --> 00:00:28,200
+المستشفى وعنده اللي هو عطش، fast polydipsia، بوليوريا
+
+5
+00:00:28,200 --> 00:00:36,820
+وفيه يعني frequent urination، و vomiting on
+
+6
+00:00:36,820 --> 00:00:41,920
+admission. Blood specimens were collected for
+
+7
+00:00:41,920 --> 00:00:44,480
+routine chemistries and gases with the following
+
+8
+00:00:44,480 --> 00:00:52,020
+results. بيأخذوا منه عينة وفحصوا الـ electrolytes في
+
+9
+00:00:52,020 --> 00:00:55,730
+السوديوم والبوتاسيوم والـ chloride. السوديوم زي ما
+
+10
+00:00:55,730 --> 00:00:59,870
+واضح أنه فيه انخفاض. الـ sodium، البوتاسيوم
+
+11
+00:00:59,870 --> 00:01:05,810
+طبيعي. الكلورايد برضه اللي هو منخفض. الـ total CO2
+
+12
+00:01:05,810 --> 00:01:15,350
+منخفض. 14. اليوريا فيها ارتفاع في اليوريا، وفي
+
+13
+00:01:15,350 --> 00:01:21,390
+الكرياتينين كمان مرتفعين. والجلوكوز مرتفع بشكل
+
+14
+00:01:21,390 --> 00:01:28,780
+كبير: 1063 milligram per deciliter. والـ pH في عندنا
+
+15
+00:01:28,780 --> 00:01:33,220
+انخفاض في الـ pH، اللي هو 7.18، يعني في عندنا
+
+16
+00:01:33,220 --> 00:01:40,400
+acidosis موجود. طبعاً من الـ من
+
+17
+00:01:40,400 --> 00:01:44,240
+اللي هو الـ presentation لـ الـ case. طفل صغير عشر
+
+18
+00:01:44,240 --> 00:01:51,850
+سنين عمره، السكر مرتفع بشكل كبير. عندنا اللي هو الـ pH
+
+19
+00:01:51,850 --> 00:01:56,330
+منخفض طبعاً، في عنده Acidosis، والـ CO2 طبعاً منخفض.
+
+20
+00:01:56,330 --> 00:02:01,550
+فيعني غالباً الطفل هذا، بعد الارتفاع الكبير
+
+21
+00:02:01,550 --> 00:02:04,590
+بالجلوكوز، في عنده اللي هو الـ Type I Diabetes
+
+22
+00:02:04,590 --> 00:02:08,670
+Mellitus. واحنا قلنا من الـ complications اللي هو
+
+23
+00:02:08,670 --> 00:02:16,260
+الـ acute يعني لـ Type I، اللي بيصير في عندنا اللي هو
+
+24
+00:02:16,260 --> 00:02:22,220
+ketoacidosis. بيصير فيه ketoacidosis. يبقى نبين أن
+
+25
+00:02:22,220 --> 00:02:26,780
+الحالة هذه في عندنا اللي هو صورة الـ ketoacidosis.
+
+26
+00:02:26,780 --> 00:02:31,860
+الآن في صورة الـ ketoacidosis ده، several
+
+27
+00:02:31,860 --> 00:02:35,260
+metabolic arrangements. في عندنا العديد من اللي هو
+
+28
+00:02:35,260 --> 00:02:37,660
+التغيرات اللي بتصير، بما يتعلق بالـ metabolism
+
+29
+00:02:37,660 --> 00:02:44,140
+للـ carbohydrates، للـ proteins، للـ lipids. بالنسبة لـ
+
+30
+00:02:44,140 --> 00:02:49,260
+carbohydrates، عندنا إذا الإنسولين موجود بشكل طبيعي،
+
+31
+00:02:49,260 --> 00:02:54,260
+الإنسولين يدفع إلى تغيير الجلوكوز إلى glycogen
+
+32
+00:02:54,260 --> 00:03:00,180
+الهيباتيكي. إذا الإنسولين موجود، تمام؟ الآن في
+
+33
+00:03:00,180 --> 00:03:03,480
+الـ Diabetic Ketoacidosis، انعدام الإنسولين يسبب في
+
+34
+00:03:03,480 --> 00:03:06,930
+انهيار الـ glycogen. مش موجود عندنا الإنسولين، اللي
+
+35
+00:03:06,930 --> 00:03:11,830
+فعلياً للجلوكوز، ما فيش شيء اللي يدخله إلى داخل
+
+36
+00:03:11,830 --> 00:03:15,410
+الخلايا. عشان هيك زي ما شفنا الجلوكوز مرتفع بشكل
+
+37
+00:03:15,410 --> 00:03:21,650
+كبير في البلازما: 1260. وبالتالي اللي هو الـ
+
+38
+00:03:21,650 --> 00:03:26,090
+hyperglycemia اللي بشكل كبير الموجودة. بالنسبة لـ
+
+39
+00:03:26,090 --> 00:03:32,430
+lipid metabolism. الإنسولين برضه يفتح lipogenesis. إذا
+
+40
+00:03:32,430 --> 00:03:36,850
+الإنسولين موجود، برضه بيعمل هو طبعاً اللي هو تصنيع
+
+41
+00:03:36,850 --> 00:03:41,670
+الدهون، و induction لتصنيع الدهون. لكن في الـ DKA،
+
+42
+00:03:41,670 --> 00:03:45,530
+insufficient insulin leads to lipolysis with the
+
+43
+00:03:45,530 --> 00:03:50,710
+production of glycerol and fatty acids. لأن ما زال
+
+44
+00:03:50,710 --> 00:03:56,050
+الإنسولين مش موجود، تمام؟ بيصير في عندنا الـ lysis لـ
+
+45
+00:03:57,680 --> 00:04:01,440
+الجليكوجين من الكبد، يعني عن طريق اللي هو
+
+46
+00:04:01,440 --> 00:04:04,880
+glucogenolysis، والجلوكونيوجينيسيس، تمام؟ لأن
+
+47
+00:04:04,880 --> 00:04:08,380
+الجلوكونيوجينيسيس عندنا اللي هو طبعاً يعني تصنيع
+
+48
+00:04:08,380 --> 00:04:11,660
+الجلوكوز from non-carbohydrate sources، زي اللي هو
+
+49
+00:04:11,660 --> 00:04:15,700
+اللبيدات، وأيضاً زي الـ proteins، تمام؟ يعني بيصير في
+
+50
+00:04:15,700 --> 00:04:21,600
+عندنا ليپوليزيس، وبيصير طبعاً اللي هو إنتاج لجليسرول
+
+51
+00:04:21,600 --> 00:04:26,160
+و fatty acids. الـ Fatty acids are further metabolized
+
+52
+00:04:26,160 --> 00:04:30,420
+for energy. بيبصير في عندنا Oxidation لـ الـ Fatty acids
+
+53
+00:04:30,420 --> 00:04:35,840
+وبينتج عندنا الـ ketones المختلفة: الـ Beta
+
+54
+00:04:35,840 --> 00:04:39,560
+-hydroxybutyrate، وعندنا الـ Acetoacetate، وعندنا
+
+55
+00:04:39,560 --> 00:04:46,260
+أيضاً برضه الـ Acetone. فهدول الثلاثة ketones، أو الـ
+
+56
+00:04:46,260 --> 00:04:49,440
+ketones اللي بينتج عندنا. أيضاً الـ deranged
+
+57
+00:04:49,440 --> 00:04:53,800
+protein metabolism. برضه insufficient insulin leads
+
+58
+00:04:53,800 --> 00:04:56,580
+to proteolysis. زي ما قلنا، لأن فيه gluconeogenesis
+
+59
+00:04:56,580 --> 00:05:00,920
+حيصير، وبالتالي بيصير عندنا breakdown للـ proteins، عشان
+
+60
+00:05:00,920 --> 00:05:07,140
+يتم استخدام الـ amino acids في الحصول على طاقة.
+
+61
+00:05:07,140 --> 00:05:10,500
+ويبقى
+
+62
+00:05:10,500 --> 00:05:12,920
+Leads to proteolysis. الـ negative nitrogen balance
+
+63
+00:05:13,770 --> 00:05:17,570
+بيصير negative nitrogen balance. بشكل طبيعي بيكون
+
+64
+00:05:17,570 --> 00:05:24,630
+فينا الـ nitrogen الداخل يتساوي الخارج. لأن في هذه الحالة
+
+65
+00:05:24,630 --> 00:05:27,850
+بيصير فينا negative nitrogen balance. إيش يعني؟
+
+66
+00:05:27,850 --> 00:05:33,710
+يعني بيصير فينا اللي طالع أكثر من اللي داخل. طيب
+
+67
+00:05:33,710 --> 00:05:37,050
+برضه اللي بيصير فينا: electrolyte imbalances.
+
+68
+00:05:37,050 --> 00:05:40,790
+Hyperglycemia may lead to osmotic diuresis and
+
+69
+00:05:40,790 --> 00:05:47,130
+urinary sodium loss. لأن الجلوكوز أسموزي أكثر،
+
+70
+00:05:47,130 --> 00:05:55,170
+يعني لو أنا عندي جلوكوز، فيه عندنا المايه، زي الـ
+
+71
+00:05:55,170 --> 00:06:00,610
+sodium مثلاً برضه، يبدأ
+
+72
+00:06:00,610 --> 00:06:04,390
+عندنا الآن لما بيصير، يرتفع، زي ما شفنا عندنا
+
+73
+00:06:04,390 --> 00:06:10,970
+ارتفاع بشكل كبير للجلوكوز. وزي ما أنتم عارفين أن
+
+74
+00:06:10,970 --> 00:06:15,270
+الـ threshold لـ glucose reabsorption في الكلى هو
+
+75
+00:06:15,270 --> 00:06:20,210
+تقريباً 180. يبقى عندنا 1260، يبقى أكيد في عندنا خروج
+
+76
+00:06:20,210 --> 00:06:26,230
+ لكميات كبيرة من الجلوكوز عن طريق الـ urine. ومازال
+
+77
+00:06:26,230 --> 00:06:29,370
+osmotically active. يبقى هيطلع معاه كمان إيش؟ كميات
+
+78
+00:06:29,370 --> 00:06:32,410
+كبيرة من المايه. عشان هيك عند هذا الطفل كان فيه
+
+79
+00:06:32,410 --> 00:06:36,930
+polyuria، في اللي هو urination بشكل اللي هو كبير. و
+
+80
+00:06:36,930 --> 00:06:41,230
+هذا اللي أدى إلى الـ polydipsia، حدوث الـ polydipsia،
+
+81
+00:06:41,230 --> 00:06:47,370
+لأنه لما بيفقد كميات كبيرة من المايه، هذا هيغير من
+
+82
+00:06:47,370 --> 00:06:52,110
+الـ osmolality، تمام؟ وبالتالي هيصير فيه إحساس
+
+83
+00:06:52,110 --> 00:06:59,470
+بالعطش. عند هذا الطفل، ده sodium depletion. لأن إذا
+
+84
+00:06:59,470 --> 00:07:02,530
+بقولنا بيصير في عندنا برضه sodium loss. Sodium
+
+85
+00:07:02,530 --> 00:07:06,410
+depletion further worsened by vomiting. كمان الـ
+
+86
+00:07:06,410 --> 00:07:09,450
+vomiting اللي عند هذا الطفل، برضه هذا زاد مشكلة
+
+87
+00:07:09,450 --> 00:07:14,810
+اللي هو فقدان sodium عند الطفل. However,
+
+88
+00:07:14,930 --> 00:07:20,010
+hypernatremia is a common finding in DKA. بحيث أن
+
+89
+00:07:20,010 --> 00:07:25,010
+الصوديوم منخفض. لكن ممكن في حالات أخرى نلاقي أن
+
+90
+00:07:25,010 --> 00:07:30,190
+الصوديوم مرتفع. common finding when dehydration
+
+91
+00:07:30,190 --> 00:07:37,770
+predominates over sodium loss. لأن هنا في عندي فقد
+
+92
+00:07:37,770 --> 00:07:42,370
+لسوائل بكمية كبيرة. الآن في عندي فقد للصوديوم، لكن
+
+93
+00:07:42,370 --> 00:07:49,570
+فقد المايه أكبر من فقد الصوديوم، تمام؟ وبالتالي كمية
+
+94
+00:07:49,570 --> 00:07:55,170
+الصوديوم الموجودة عندي، تمام؟ بتصير دايبة في كمية
+
+95
+00:07:55,170 --> 00:07:59,630
+أقل من المايه. يبقى الـ concentration بتـرتفع، تمام؟
+
+96
+00:07:59,630 --> 00:08:04,990
+اللي هو في عندنا اللي هو relative increase. يعني
+
+97
+00:08:04,990 --> 00:08:07,950
+زي كان عندي الـ sodium، كمية sodium مثلاً على سبيل
+
+98
+00:08:07,950 --> 00:08:16,190
+المثال: 1 غرام، دايبة مثلاً في لتر. الآن صار عندي
+
+99
+00:08:16,190 --> 00:08:22,110
+0.9 غرام دايبة في نصف لتر. يبقى صار فيه أن دي
+
+100
+00:08:22,110 --> 00:08:25,250
+فقد للمايه، كمية كبيرة، فقد للصوديوم، لكن مقاومة
+
+101
+00:08:25,250 --> 00:08:30,090
+المايه أقل. يبقى هذا أدى إلى ارتفاع في الواقع، أو
+
+102
+00:08:30,090 --> 00:08:32,910
+بيؤدي يعني عادةً إلى ارتفاع في الـ sodium
+
+103
+00:08:32,910 --> 00:08:36,230
+concentration. لكن زي ما قلنا، هان الحالة إنه فيه
+
+104
+00:08:36,230 --> 00:08:39,990
+vomiting. فـ الـ vomiting هذا كمان أدى إلى فقد للـ
+
+105
+00:08:39,990 --> 00:08:43,370
+الصوديوم. لأن كان فيه أن الصوديوم شوية أقل من
+
+106
+00:08:43,370 --> 00:08:47,590
+الطبيعي. الأسيدوزيس المرتبطة مع الـ DKA تسبب في تغيير
+
+107
+00:08:47,590 --> 00:08:52,350
+البوتاسيوم بشكل أكبر، بشكل سلبي، يتسبب في تغيير
+
+108
+00:08:52,350 --> 00:08:58,230
+الـ hyperkalemia. الآن من ميكانزمات التغيير
+
+109
+00:08:58,230 --> 00:09:06,070
+للأسيدوزيس، أن بيصير في عندي تغيير للبوتاسيوم، لما
+
+110
+00:09:06,070 --> 00:09:11,370
+يكون في عندي أسيدوزيس. بيصير فيه دخول للهيدروجين
+
+111
+00:09:11,370 --> 00:09:17,730
+أيون إلى داخل الـ red blood cells، عشان نقلل من الـ
+
+112
+00:09:17,730 --> 00:09:21,930
+hydrogen ions الموجودة في البلازما. يعني نحاول نعدل
+
+113
+00:09:21,930 --> 00:09:25,710
+من الانخفاض في الـ pH اللي صار. يبقى الـ hydrogen
+
+114
+00:09:25,710 --> 00:09:30,090
+ions بتدخل إلى داخل الـ red blood cells. طبعاً كما
+
+115
+00:09:30,090 --> 00:09:33,530
+تعرفون أن هناك الـ electric neutrality. يعني دائماً
+
+116
+00:09:33,530 --> 00:09:37,030
+يجب أن يكون عندي عدد الـ ions الموجبة يساوي عدد
+
+117
+00:09:37,030 --> 00:09:39,950
+الـ ions السالبة. يبقى إذا دخلت الـ hydrogen
+
+118
+00:09:39,950 --> 00:09:43,070
+ions اللي موجبة إلى داخل الخلية، يبقى لازم يطلع
+
+119
+00:09:43,070 --> 00:09:46,830
+عندي اللي هو positive ion. إيش اللي بيطلع؟ الـ
+
+120
+00:09:46,830 --> 00:09:52,110
+potassium اللي بيطلع، تمام؟ يدخل hydrogen ion،
+
+121
+00:09:52,110 --> 00:09:55,390
+وبالتالي بنقلل من الـ hydrogen ion، وبالتالي بنحسن
+
+122
+00:09:55,390 --> 00:10:00,310
+من الـ pH، وبيطلع عندي اللي هو بوتاسيوم. However,
+
+123
+00:10:00,310 --> 00:10:03,830
+because potassium is also lost renally and extra-
+
+124
+00:10:03,830 --> 00:10:08,370
+renally, total body potassium is often depleted. لأن
+
+125
+00:10:08,370 --> 00:10:12,010
+برضه بهذه الحالة كان أن البوتاسيوم طبيعي.
+
+126
+00:10:12,010 --> 00:10:17,590
+البوتاسيوم 3.5. طبعاً، لكن يعني برضه ممكن يكون فيه
+
+127
+00:10:17,590 --> 00:10:20,410
+عندنا hyperkalemia. لكن زي ما قلنا إنه في عندنا
+
+128
+00:10:20,410 --> 00:10:25,730
+loss للبوتاسيوم عن طريق الـ kidney، وعندنا برضه عن
+
+129
+00:10:25,730 --> 00:10:30,310
+طريق الـ vomiting. وبالتالي يعني ما كانش عندنا ارتفاع
+
+130
+00:10:30,310 --> 00:10:32,030
+في البوتاسيوم. كان البوتاسيوم الـ concentration
+
+131
+00:10:32,030 --> 00:10:38,000
+تبعه اللي هو طبيعي. الآن هناك ملاحظة أن هذه الحالات
+
+132
+00:10:38,000 --> 00:10:41,900
+أن السكر مرتفع بشكل كبير. لأن من العلاج اللي بيعطوه
+
+133
+00:10:41,900 --> 00:10:47,080
+لهذا المريض، لازم يعطوه insulin، تمام؟ عشان يخفضوا
+
+134
+00:10:47,080 --> 00:10:51,560
+من مستوى السكر. الآن المشكلة أن الـ insulin therapy
+
+135
+00:10:51,560 --> 00:11:01,400
+هذه ممكن تؤدي إلى hypokalemia. لأن الإنسولين يزيد من
+
+136
+00:11:01,400 --> 00:11:04,840
+دخول البوتاسيوم إلى داخل الخلايا.
+
+137
+00:11:09,780 --> 00:11:13,240
+الدخول اللي هو الـ potassium بيزيد من اللي هو الـ
+
+138
+00:11:13,240 --> 00:11:17,140
+ATP، اللي هو الـ sodium potassium pump activity.
+
+139
+00:11:17,140 --> 00:11:20,600
+وبالتالي بيزيد من دخول الـ potassium إلى داخل
+
+140
+00:11:20,600 --> 00:11:24,660
+الخلية. وبالتالي ممكن مع العلاج اللي يُعطيها، بيشير
+
+141
+00:11:24,660 --> 00:11:28,660
+بيكون فيه مراقبة مستمرة للمريض، لأن هذا ممكن يؤدي
+
+142
+00:11:28,660 --> 00:11:30,760
+إلى حدوث hypokalemia.
+
+143
+00:11:32,850 --> 00:11:36,170
+بالإضافة إلى البوتاسيوم، الفوسفات أيضاً تتحرك بشكل
+
+144
+00:11:36,170 --> 00:11:42,350
+intraceullular مع الإنسولين. وبالتالي برضه ممكن
+
+145
+00:11:42,350 --> 00:11:46,010
+أن يكون هناك انخفاض في البوتاسيوم، وهيبوفسفاتيميا.
+
+146
+00:11:46,010 --> 00:11:49,990
+يبقى أثناء العلاج، لابد من المراقبة المستمرة
+
+147
+00:11:49,990 --> 00:11:56,200
+للـ electrolytes عند المرضى. طبعاً هنا برضه من الشغلات
+
+148
+00:11:56,200 --> 00:11:59,680
+اللي بتتأثر عندنا اللي هو الـ acid-base balance، زي
+
+149
+00:11:59,680 --> 00:12:04,120
+ما شفنا أن الـ pH كانت منخفضة. كان في عندنا اللي هو
+
+150
+00:12:04,120 --> 00:12:07,840
+الـ acidosis. Production of ketoacids in DKA causes
+
+151
+00:12:07,840 --> 00:12:13,760
+high anion gap metabolic acidosis with beta
+
+152
+00:12:13,760 --> 00:12:17,480
+hydroxybutyrate more abundant than acetoacetate.
+
+153
+00:12:18,920 --> 00:12:22,380
+يبقى زي ما قلنا أنه عندنا بيصير ليپوليزيس، بيصير
+
+154
+00:12:22,380 --> 00:12:25,880
+فيه الـ oxidation لـ fatty acids، بيصير عندنا إنتاج
+
+155
+00:12:25,880 --> 00:12:31,960
+لكيتون أسيد. أو الكيتون أسيد هذه اللي بيصير في عندنا
+
+156
+00:12:31,960 --> 00:12:38,260
+أو بتلعب دور في انخفاض الـ pH، وزيادة الـ hydrogen
+
+157
+00:12:38,260 --> 00:12:46,680
+ions. في عندنا اللي هو causes high anion gap. حنحكي
+
+158
+00:12:46,680 --> 00:12:49,520
+عن الـ anions gap لما نحكي عن الـ electrolytes، لأن
+
+159
+00:12:49,520 --> 00:12:54,800
+الـ anions gap عبارة عن الـ unmeasured
+
+160
+00:12:54,800 --> 00:12:59,560
+anions مطروح منها الـ unmeasured cations، والمفروض
+
+161
+00:12:59,560 --> 00:13:04,780
+تكون يعني في لها reference interval معين. إبداعاً
+
+162
+00:13:04,780 --> 00:13:09,080
+يكون فينا ارتفاع في الـ anions gap، لأن صار فينا
+
+163
+00:13:09,080 --> 00:13:15,870
+زيادة في الـ anions الموجودة عند المريض. طيب الـ
+
+164
+00:13:15,870 --> 00:13:19,650
+lactic acid برضه production اللي ممكن برضه تزيد
+
+165
+00:13:19,650 --> 00:13:25,750
+بسبب الـ poor circulation، و shock. هذه برضه اللي ممكن
+
+166
+00:13:25,750 --> 00:13:30,230
+تزيد من الـ metabolic acidosis. ولي changes in urea و
+
+167
+00:13:30,230 --> 00:13:33,170
+الكرياتينين. لأن زي ما شفنا فيه ارتفاع في اليوريا
+
+168
+00:13:33,170 --> 00:13:37,490
+والكرياتينين. طبعاً ليش؟ لأن زي ما شفنا إنه فيه
+
+169
+00:13:37,490 --> 00:13:41,830
+dehydration، في فقد كميات كبيرة من المايه. يبقى
+
+170
+00:13:41,830 --> 00:13:47,910
+عند الـ blood volume قليل، صحيح؟ يبقى في هذه الحالة
+
+171
+00:13:47,910 --> 00:13:54,150
+في عندنا الـ pre-renal azotemia. زي ما أنتم عارفين
+
+172
+00:13:54,820 --> 00:13:59,400
+اللي هو الارتفاع في اليوريا. في ثلاثة أسباب فيها
+
+173
+00:13:59,400 --> 00:14:01,460
+اللي هو الـ pre-renal، والـ renal، والـ post-renal.
+
+174
+00:14:01,460 --> 00:14:06,700
+طبعاً حالات اللي هو النقص في blood volume، أو إذا
+
+175
+00:14:06,700 --> 00:14:10,060
+كان في عندنا مشكلة في القلب. وبالتالي يعني تؤدي
+
+176
+00:14:10,060 --> 
+
+223
+00:17:27,600 --> 00:17:32,360
+اليورين، وهنا سيكون هناك Osmotic Diuresis سنقول أن
+
+224
+00:17:32,360 --> 00:17:35,420
+الجلوكوز اسمه Osmotically Active، سيكون هناك خروج
+
+225
+00:17:35,420 --> 00:17:38,740
+لكميات كبيرة من الجلوكوز، وهذا سيسحب معه كميات
+
+226
+00:17:38,740 --> 00:17:44,340
+كبيرة من الماء في اليورين أيضًا، وهذا أيضًا سيؤدي إلى
+
+227
+00:17:44,340 --> 00:17:48,840
+فقد، وسيعمل لنا imbalance لأنه يصبح فقد للإلكترولايت
+
+228
+00:17:50,670 --> 00:17:55,370
+وبالنهاية سيصبح هناك Hypovolemia، انخفاض في blood
+
+229
+00:17:55,370 --> 00:17:59,950
+volume، وبالتالي dehydration في الـ plasma
+
+230
+00:17:59,950 --> 00:18:04,510
+osmolality التي صارت في البلازما، زي ما تعرفين الـ
+
+231
+00:18:04,510 --> 00:18:09,010
+hypothalamus  مستجيب للـ osmolality التي في الدم، لأن
+
+232
+00:18:09,010 --> 00:18:13,820
+لما يزيد هنا الـ osmolality، الـ hypothalamus المفروض
+
+233
+00:18:13,820 --> 00:18:18,080
+ماذا يفعل؟ اللي هو يزيد من إفراز الـ antidiuretic
+
+234
+00:18:18,080 --> 00:18:23,060
+hormone، عشان يصبح عنده more absorption للماء
+
+235
+00:18:23,060 --> 00:18:29,180
+ويعطي إحساس بالعطش، يبقى هنا في عندنا اللي هو
+
+236
+00:18:29,180 --> 00:18:35,600
+thirst، هنا اللي في عندنا يوريميا، اللي هو ارتفاع في
+
+237
+00:18:35,600 --> 00:18:49,100
+مستوى اليوريا والـHypovolemia التي صارت، وبالتالي قلل
+
+238
+00:18:49,100 --> 00:18:54,340
+من الـ Glomerular Filtration Rate، وكما تعرفون كلما
+
+239
+00:18:54,340 --> 00:18:59,120
+قلت Glomerular Filtration Rate، كل معناه أن الـ
+
+240
+00:18:59,120 --> 00:19:02,580
+Substances المختلفة التي بيستخدم الـ filtration قلت
+
+241
+00:19:02,580 --> 00:19:08,870
+وبالتالي حصل ارتفاع/انخفاض في الـ Renal
+
+242
+00:19:08,870 --> 00:19:12,610
+Hydrogen Excretion، و أيضًا انخفاض في الـ Glomerular
+
+243
+00:19:12,610 --> 00:19:17,590
+Filtration Rate، هذا قلل من الـ Hydrogen Ion
+
+244
+00:19:17,590 --> 00:19:21,350
+Excretion، لأنه المفروض أنا لما يرتفع عندي الـ
+
+245
+00:19:21,350 --> 00:19:25,930
+Hydrogen Ions في الدم، المفروض بيصير في عندي more
+
+246
+00:19:25,930 --> 00:19:30,240
+Excretion of Hydrogen Ions، الآن مع انخفاض اللي حصل
+
+247
+00:19:30,240 --> 00:19:34,020
+في الـ Glucose Reception Rate، بيكون أقل من الـ
+
+248
+00:19:34,020 --> 00:19:36,340
+Excretion التي للـ hydrogen ions، و أيضًا ساعد
+
+249
+00:19:36,340 --> 00:19:44,080
+في حدوث الـ Acidosis، بالإضافة للكيتونات التي ارتفعت
+
+250
+00:19:44,080 --> 00:19:50,640
+و الـ Ketones أيضًا، وبالتالي أيضًا بتزيد من الـ
+
+251
+00:19:50,640 --> 00:19:53,440
+release  لـ hydrogen ions، وبالتالي بتلعب دور في الـ
+
+252
+00:19:53,440 --> 00:19:58,780
+acidosis التي صارت، طيب في المرضى هؤلاء الذين يكون
+
+253
+00:19:58,780 --> 00:20:02,560
+عندهم Ketoacidosis، لو جينا جربنا و شمينا نفس
+
+254
+00:20:02,560 --> 00:20:09,370
+بتاعهم، نجد نفس فواكهي هكذا، فيه ريحة عطرة حلوة، السبب
+
+255
+00:20:09,370 --> 00:20:12,770
+هو الـ Ketone Body، برضه اللي هو الـ Acetone الذي
+
+256
+00:20:12,770 --> 00:20:17,830
+يسمح بـ Exhalation أو خروج مع اللي هو الزفير
+
+257
+00:20:17,830 --> 00:20:23,070
+الارتفاع في الـ Ketone Bodies أيضًا ممكن هو الذي
+
+258
+00:20:23,070 --> 00:20:27,490
+عمل الـ Vomiting، هو سبب الـ Vomiting، تمام؟ لأن الـ
+
+259
+00:20:27,490 --> 00:20:31,290
+Ketones عبارة عن اللي هو acidic substance
+
+260
+00:20:31,290 --> 00:20:38,920
+وبيؤدوا إلى غثيان، وبالتالي الـ vomiting هو سبب
+
+261
+00:20:38,920 --> 00:20:45,060
+الارتفاع في الكيتونات، بالنسبة للـ Acidosis
+
+262
+00:20:45,060 --> 00:20:48,460
+احنا قلنا أنه صار في عندنا Acidosis، الآن هؤلاء
+
+263
+00:20:48,460 --> 00:20:54,140
+الأشخاص بيكون فيه النفس عندهم سريع، اللي بيصير فيه
+
+264
+00:20:54,140 --> 00:20:56,080
+Hyperventilation
+
+265
+00:20:59,350 --> 00:21:02,610
+سبب الـ Hyperventilation هي عبارة عن الـ
+
+266
+00:21:02,610 --> 00:21:07,710
+compensation mechanism، لأننا سنحكي عليها بالتفصيل
+
+267
+00:21:07,710 --> 00:21:11,370
+هذه لما نحكي على الـ acid imbalance، لما يكون لدي
+
+268
+00:21:11,370 --> 00:21:14,830
+متابوليك أسيدوزيس، ماهو الـ compensation mechanism
+
+269
+00:21:14,830 --> 00:21:20,630
+بتكون عن طريق الجهاز الذي لم يُصب، في هذه الحالة
+
+270
+00:21:20,630 --> 00:21:24,670
+بتكون الـ lungs، تتجه الـ lungs، تعمل الـ compensation
+
+271
+00:21:24,670 --> 00:21:31,480
+تحاول التعديل من اللي هو الـ pH، طبعًا هذا عندنا الذي
+
+272
+00:21:31,480 --> 00:21:34,920
+هو في المعادلة، بحثت عنها مرات عدة، عليك بالصدق إنها لأ
+
+273
+00:21:34,920 --> 00:21:43,580
+الآن احنا عندنا الـ CO2 مع الـ H2O بيعطيني H2CO3، هذا
+
+274
+00:21:43,580 --> 00:21:48,540
+بيصير له اللي هو تحليل إلى HCO3 و hydrogen ions، طيب
+
+275
+00:21:48,540 --> 00:21:53,380
+الآن لما يرتفع عندي الـ hydrogen ions، طيب هنا
+
+276
+00:21:53,380 --> 00:22:04,190
+عندنا الـ H2O مع الـ CO2، قلت بيعطينا H2CO3، هذه
+
+277
+00:22:04,190 --> 00:22:10,870
+بيصير لها الـ association إلى HCO3 و Hydrogen، اللي هو
+
+278
+00:22:10,870 --> 00:22:16,650
+compensation mechanism، لما يحدث فينا ارتفاع في الـ
+
+279
+00:22:16,650 --> 00:22:20,630
+hydrogen ions، يحدث فيه Hyperventilation، ماهو
+
+280
+00:22:20,630 --> 00:22:24,690
+Hyperventilation؟ يعني معدل التنفس يزيد، تمام؟ لما
+
+281
+00:22:24,690 --> 00:22:28,730
+معدل التنفس يزيد، ماذا يحدث فينا؟ more exhalation
+
+282
+00:22:28,730 --> 00:22:33,390
+of CO2، يحدث فينا فقط لكميات أكبر من الـ CO2، إذًا
+
+283
+00:22:33,390 --> 00:22:40,020
+ماذا يحدث لـ CO2؟ هينخفض، تمام؟ هينزل، لأن لما ينزل الـ
+
+284
+00:22:40,020 --> 00:22:44,440
+CO2، بيصير في عندنا المعادلة بتمشي بهذا الاتجاه
+
+285
+00:22:44,440 --> 00:22:52,020
+يبقى بيصير في عندي hydrogen ions  ترتبط مع HCO3 عشان
+
+286
+00:22:52,020 --> 00:22:55,800
+يعطينا H2CO3، عشان نعوض اللي هو النقص الذي في الـ CO2
+
+287
+00:22:55,800 --> 00:23:00,220
+الذي الجسم يتخلص منه، يبقى احنا إيش بنعمل؟
+
+288
+00:23:00,220 --> 00:23:05,160
+جالسين نتخلص من الـ hydrogen ions الموجودة في
+
+289
+00:23:05,160 --> 00:23:12,400
+البلازما، طيب الحالة الثانية عندنا
+
+290
+00:23:12,400 --> 00:23:18,080
+A 27-year-old man was referred to the local
+
+291
+00:23:18,080 --> 00:23:22,630
+diabetic clinic، يبقى الشاب عمره 27 سنة، he had been
+
+292
+00:23:22,630 --> 00:23:26,590
+diagnosed as having type 2 diabetes mellitus، يعني
+
+293
+00:23:26,590 --> 00:23:31,690
+عنده ارتفاع في السكر، يعني من الفحوصات التي قاموا بها
+
+294
+00:23:31,690 --> 00:23:34,070
+توصّلوا أنه عنده type 2 diabetes mellitus three
+
+295
+00:23:34,070 --> 00:23:38,010
+years previously، and his control was poor، يعني
+
+296
+00:23:38,010 --> 00:23:42,330
+كانت ثلاث سنوات له، وتحكمه بالجلوكوز يعني مستويات
+
+297
+00:23:42,330 --> 00:23:46,710
+الجلوكوز دائمًا عنده مرتفعة، والدليل أنه هي
+
+298
+00:23:46,710 --> 00:23:53,450
+عندنا أيضًا الـ hemoglobin A1C 9.6%، despite being on
+
+299
+00:23:53,450 --> 00:23:58,050
+an optimal dose of metformin، العلاج الذي كان يأخذه
+
+300
+00:23:58,050 --> 00:24:03,170
+هذا المريض هو الـ metformin، طبعًا هو في مرضى السكري
+
+301
+00:24:03,170 --> 00:24:09,310
+يعني عادة أول شيء يبدأون معهم بـ diet، ممكن exercise،
+
+302
+00:24:09,310 --> 00:24:13,570
+تخفيف وزن، فترة،  إلخ،  وإن لم ينجح ذلك،
+
+303
+00:24:13,570 --> 00:24:16,730
+ولسه الجلوكوز مرتفع، يبدأون معهم بالـ metformin،
+
+304
+00:24:16,730 --> 00:24:21,830
+أو الـ metformin، زي ما تعرفين، يعمل على تقليل الـ
+
+305
+00:24:21,830 --> 00:24:28,600
+release of glucose from the liver، المشكلة عند مرضى
+
+306
+00:24:28,600 --> 00:24:32,200
+السكر، أنه مع الارتفاع في الجلوكوز الموجود، لأن
+
+307
+00:24:32,200 --> 00:24:41,580
+الكبد أيضًا يزيد اللي هو ينتج الجلوكوز، الآن الـ
+
+308
+00:24:41,580 --> 00:24:44,300
+general practitioner was wondering whether his man
+
+309
+00:24:44,300 --> 00:24:49,520
+needed to start on insulin، يعني مع الـ poor
+
+310
+00:24:49,520 --> 00:24:56,030
+control للجلوكوز الموجود، فكر أنه يبدأ له بالإنسولين
+
+311
+00:24:56,030 --> 00:25:01,690
+عدة أعضاء عائلات قريبة أيضًا كانوا مرتبطين بشكل
+
+312
+00:25:01,690 --> 00:25:04,970
+عام، عام، عام، عام، عام، عام
+
+313
+00:25:04,970 --> 00:25:10,210
+عام، عام، عام، عام، عام
+
+314
+00:25:10,210 --> 00:25:10,630
+عام، عام، عام، عام، عام
+
+315
+00:25:10,630 --> 00:25:10,670
+عام، عام، عام، عام، عام، عام
+
+316
+00:25:10,670 --> 00:25:13,640
+عام، عام، عام، عام، عام،  الـ Body
+
+317
+00:25:13,640 --> 00:25:18,460
+Mass Index  ليس عالية، يعني ليس obese، لأنه 26، يعني
+
+318
+00:25:18,460 --> 00:25:24,700
+يُعتبر طبيعيًا لغاية 24.9، تمام؟ فهو 26، يعني
+
+319
+00:25:24,700 --> 00:25:31,320
+فعليًا وزنه ليس كثير فوق الوزن الطبيعي، وضغطه طبيعي،
+
+320
+00:25:31,320 --> 00:25:37,060
+وفي عنده family history  بأنه diabetes، تمام؟
+
+321
+00:25:37,060 --> 00:25:41,580
+يعني المؤشرات لا تدل على أنه عنده type 2 diabetes
+
+322
+00:25:41,580 --> 00:25:46,400
+mellitus، هذا الشخص، In view of the strong
+
+323
+00:25:46,400 --> 00:25:49,560
+family history of diabetes، أكثر من أن he did not
+
+324
+00:25:49,560 --> 00:25:52,140
+fit the typical phenotype of type 2 diabetes
+
+325
+00:25:52,140 --> 00:25:56,000
+mellitus، لأنه relatively young، not obese، nor
+
+326
+00:25:56,000 --> 00:25:59,540
+hypertensive، possibility of maturity onset diabetes
+
+327
+00:25:59,540 --> 00:26:04,900
+of the young was raised، وهذه فعليًا مشكلة العديد
+
+328
+00:26:04,900 --> 00:26:10,360
+من الأشخاص الذين فعليًا عندهم  MODY، يتم تشخيصهم
+
+329
+00:26:10,360 --> 00:26:16,300
+خطأ على أنه عندهم type 2 diabetes mellitus، طبعًا الذي
+
+330
+00:26:16,300 --> 00:26:19,860
+... الذي زي ما أنتم شايفين، أن العلاج يختلف، يعني
+
+331
+00:26:19,860 --> 00:26:22,620
+هو تم تشخيصه على أنه type 2 diabetes mellitus،
+
+332
+00:26:22,620 --> 00:26:26,560
+يأخذ علاج، لكن فعليًا فيه poor control للجلوكوز،
+
+333
+00:26:26,560 --> 00:26:30,460
+فدعم التشخيص الصحيح أكيد يعني بيصير فينا better
+
+334
+00:26:30,460 --> 00:26:38,020
+management للمريض، الآن التشخيص ممكن عن طريق
+
+335
+00:26:38,020 --> 00:26:42,940
+الـ Molecular Analysis، Genotyping revealed a
+
+336
+00:26:42,940 --> 00:26:50,460
+mutation in the HNF1 Alpha-Gene، وهذا الجين له
+
+337
+00:26:50,460 --> 00:26:54,500
+علاقة بالـ Beta-cells  و الـ Release of Insulin،
+
+338
+00:26:54,500 --> 00:26:59,340
+و الـ mutation في هذا الجين يؤدي إلى Decrease
+
+339
+00:26:59,340 --> 00:27:05,330
+Release of Insulin from Beta-cells، هذا هو المشكلة
+
+340
+00:27:05,330 --> 00:27:14,750
+عند هذا المريض، metformin كان مُوقفًا، والآن نريد شيء
+
+341
+00:27:14,750 --> 00:27:20,590
+فقط يزيد من إطلاق الإنسولين، هناك أدوية لدينا، وهذه
+
+342
+00:27:20,590 --> 00:27:24,990
+مرحلة بعد metformin، تعمل تحفيز للبنكرياس، وتزيد
+
+343
+00:27:24,990 --> 00:27:32,490
+من إطلاق الإنسولين، هذا ما كان يحتاجه، وهو العلاج
+
+344
+00:27:33,140 --> 00:27:37,760
+الذي يُعطى له، دوز of sulphonylurea، تمام؟ هو عبارة عن
+
+345
+00:27:37,760 --> 00:27:43,300
+sulphonylurea، هذه مجموعة من الأدوية، هذه الأدوية
+
+346
+00:27:43,300 --> 00:27:49,720
+تزيد من اللي هو الـ insulin secretion، الحالة الثالثة
+
+347
+00:27:49,720 --> 00:27:53,920
+الدكتور زار المريض، ووجد أنه
+
+348
+00:27:53,920 --> 00:28:00,100
+semi-conscious،  ابنه زاره ووجد أنه
+
+349
+00:28:00,100 --> 00:28:04,440
+ليس بصحة جيدة، كأنه مغيب، الأقارب كانوا يلاحظون
+
+350
+00:28:04,440 --> 00:28:07,640
+عليه حوالي 10 أيام قبل ذلك، آخر مرة شوّفوه قبل عشر
+
+351
+00:28:07,640 --> 00:28:11,300
+أيام، كان طبيعيًا، when he had seemed well،  لم يكن فيه
+
+352
+00:28:11,300 --> 00:28:13,600
+مشكلة،  he was admitted to hospital.
+
+353
+00:28:14,320 --> 00:28:17,860
+On examination, he appeared extremely dehydrated.
+
+354
+00:28:18,560 --> 00:28:21,760
+وكان أيضًا فيه فقد كبير للسوائل، Results of
+
+355
+00:28:21,760 --> 00:28:26,970
+biochemical investigations were as follows، اليوريا
+
+356
+00:28:26,970 --> 00:28:33,510
+عندنا 38 ملي مول، أو 1006 ملي جرام بالديسيليتر، اللي
+
+357
+00:28:33,510 --> 00:28:36,170
+في عندنا ارتفاع، الكرياتنين 1.5 أيضًا
+
+358
+00:28:36,170 --> 00:28:38,590
+في عندنا ارتفاع،  ارتفاع في اليوريا، و
+
+359
+00:28:38,590 --> 00:28:41,810
+الكرياتنين، وهذا ما زال فيه dehydration زي ما
+
+360
+00:28:41,810 --> 00:28:44,770
+شَفْنا بالحالة السابقة، التي ما زال فيها dehydration
+
+361
+00:28:44,770 --> 00:28:47,990
+الذي في عندنا، اللي هو pre-renal azotemia،
+
+362
+00:28:47,990 --> 00:28:51,650
+ممكن هذه تكون التي هي سبب الارتفاع في اليوريا، و
+
+363
+00:28:51,650 --> 00:28:55,720
+الكرياتنين، عندنا الصوديوم، ارتفاع في الصوديوم،
+
+364
+00:28:55,720 --> 00:29:02,340
+البوتاسيوم طبيعي، اللي أيضًا فيه انخفاض في اللي هو
+
+365
+00:29:02,340 --> 00:29:09,280
+الـ CO2 18%، الجلوكوز أيضًا مرتفع بشكل كبير، 1098
+
+366
+00:29:09,280 --> 00:29:13,820
+ملي جرام بالديسيليتر، والـ Osmolality أيضًا عندنا
+
+367
+00:29:13,820 --> 00:29:17,060
+مرتفعة، طبعًا الناس الذين
+
+368
+00:29:23,780 --> 00:29:29,000
+مصابين بالـ diabetes mellitus، من الـ complications
+
+369
+00:29:29,000 --> 00:29:32,580
+التي ممكن تكون عندهم، الـ acute، بيصير في عندهم
+
+370
+00:29:32,580 --> 00:29:38,940
+الـ hyperosmolar non-ketotic، الذي بيصير في عندهم
+
+371
+00:29:38,940 --> 00:29:45,660
+ارتفاع في الـ osmolality، تمام؟ لكن بيكونش فيه
+
+372
+00:29:45,660 --> 00:29:50,660
+ارتفاع في الـ ketone bodies، آه، يبقى هذا الذي هو
+
+373
+00:29:50,660 --> 00:29:58,020
+الذي يفرّق، عشان هيك الذي هو الـ Ketones مهم أنه
+
+374
+00:29:58,020 --> 00:30:02,780
+يعمل اللي هو،  الذي يفرّقه، يبقى فيه عندنا severe
+
+375
+00:30:02,780 --> 00:30:07,360
+Hyperglycemia، وهذه هي التي أدّت إلى ارتفاع الـ
+
+376
+00:30:07,360 --> 00:30:10,540
+osmolality، لأن اللي قلنا بيكون Osmotically
+
+377
+00:30:10,540 --> 00:30:14,520
+active، Hyperglycemia has driven osmotic
+
+378
+00:30:14,520 --> 00:30:20,420
+diuresis، برضه نفس الفكرة، وهي تسبب في فقد الإلكترولايت
+
+379
+00:30:20,420 --> 00:30:23,040
+واختلاف  الإلكترولايت، اختلاف الإلكترولايت، اختلاف الإلكترولايت،
+
+380
+00:30:23,040 --> 00:30:24,240
+واختلاف الإلكترولايت، اختلاف الإلكترولايت، اختلاف الإلكترولايت،
+
+381
+00:30:24,240 --> 00:30:25,680
+واختلاف الإلكترولايت، اختلاف الإلكترولايت، اختلاف الإلكترولايت،
+
+382
+00:30:25,680 --> 00:30:28,220
+واختلاف الإلكترولايت، اختلاف الإلكترولايت، اختلاف الإلكترولايت،
+
+383
+00:30:28,220 --> 00:30:33,400
+واختلاف الإلكترولايت، اختلاف الإلكترولايت، اختلاف الإلكترولايت،
+
+384
+00:30:33,400 --> 00:30:39,460
+واختلاف الإلكترولايت، اختلاف الإلكترولايت، اختلاف الإلكترولايت،
+
+385
+00:30:39,460 --> 00:30:45,390
+واختلاف الإلكترولايت،  أيضًا بيصير فيه Hyperlipidemia، لكن
+
+386
+00:30:45,390 --> 00:30:48,950
+قلنا الـ vomiting هو الذي كان سبب أنه صار فيه فقدان له
+
+387
+00:30:48,950 --> 00:30:53,970
+اللي هو الـ Sodium، Total CO2 is slightly reduced،
+
+388
+00:30:53,970 --> 00:30:58,570
+due to the impaired renal function، but it's not as
+
+389
+00:30:58,570 --> 00:31:00,150
+low as what we expected in the case of
+
+390
+00:31:00,150 --> 00:31:03,270
+ketoacidosis، في الـ ketoacidosis التي شفناها كان
+
+391
+00:31:03,270 --> 00:31:06,090
+عندنا الـ CO2 concentration أقل بكثير،
+
+392
+00:31:06,090 --> 00:31:11,850
+أصبح؟ with results as abnormal as this، الشخص كان
+
+393
+00:31:11,850 --> 00:31:14,630
+مُميّزًا بالفعل، ولكن في النهاية كان قادرًا على إعطاء
+
+394
+00:31:14,630 --> 00:31:19,770
+مثال، يورين الذي أعطى نتائج خاطئة للكيتونات، وما كانش
+
+395
+00:31:19,770 --> 00:31:23,450
+فيه عندهم كيتونات، واحنا قلنا إن
+
+445
+00:35:11,910 --> 00:35:15,570
+الليلية زي ما شوفنا، طيب الحالة الأخيرة
+
+446
+00:35:26,540 --> 00:35:30,980
+A 45-year-old woman who was unable to feed, wash
+
+447
+00:35:30,980 --> 00:35:34,840
+or dress herself because of severe multiple
+
+448
+00:35:34,840 --> 00:35:39,020
+sclerosis. المعنى بيجي في عندها multiple sclerosis
+
+449
+00:35:39,020 --> 00:35:42,420
+اللي هو اتصل بالمتعدد فيه مشكلة عندها، المعروف
+
+450
+00:35:42,420 --> 00:35:46,320
+بيكون طبعًا فيه اللي هو المياه اللي بينشطه وبالتالي
+
+451
+00:35:46,320 --> 00:35:54,060
+في مشكلة عندهم بيه الـ.. طبعًا الـ nerve signal واللي
+
+452
+00:35:54,060 --> 00:35:59,440
+هو التوصيل اللي هو إشارات العصبية. وهذا طبعًا يعني
+
+453
+00:35:59,440 --> 00:36:04,040
+فيه له complications عديدة، يعني بتأثر على كل
+
+454
+00:36:04,040 --> 00:36:11,740
+نواحي الحياة عندهم: ماشي، أكل، حركة، على كل شيء. طيب، و
+
+455
+00:36:11,740 --> 00:36:14,780
+هذه المريضة اللي عمرها 45 سنة، عندها multiple
+
+456
+00:36:14,780 --> 00:36:20,610
+sclerosis وكان في CV multiple sclerosis وبالتالي هي
+
+457
+00:36:20,610 --> 00:36:24,650
+لا هي قادرة تأكل، ولا قادرة تلبس، ولا قادرة تتحمم، ولا
+
+458
+00:36:24,650 --> 00:36:29,470
+قادرة تعمل أي شيء، وكانت موجودة فعليًا في nursing
+
+459
+00:36:29,470 --> 00:36:32,730
+home، يعني في دار للرعاية، وهم اللي كانوا باهتموا
+
+460
+00:36:32,730 --> 00:36:39,750
+فيها. About six hours after a visit by relatives, it
+
+461
+00:36:39,750 --> 00:36:44,850
+was found that she could not be roused. يبقى ضروري
+
+462
+00:36:44,850 --> 00:36:48,600
+أقاربها كان في زيارة.  بعد ست ساعات من
+
+463
+00:36:48,600 --> 00:36:54,640
+انتهاء الزيارة، لقوها وهي كانت مش مصحصة  حقيقيًا بعد
+
+464
+00:36:54,640 --> 00:36:58,920
+ست
+
+465
+00:36:58,920 --> 00:37:04,160
+ساعات.  عند وصولها إلى المستشفى on admission to a hospital
+
+466
+00:37:04,160 --> 00:37:08,900
+she was found to be extremely hypoglycemic. وهذا
+
+467
+00:37:08,900 --> 00:37:13,080
+السبب أن هي زي ما إيش في نقص شديد بالسكر وglucose
+
+468
+00:37:13,080 --> 00:37:16,870
+اربعة و ثلاثين milligram per deciliter. تعرفوا أقل
+
+469
+00:37:16,870 --> 00:37:20,970
+من الخمسين، اللي هو الشخص يدخل في hypoglycemia.
+
+470
+00:37:20,970 --> 00:37:23,570
+وطبعًا أه، يعني هذه تعتبر life threatening condition،
+
+471
+00:37:23,570 --> 00:37:26,950
+يعني ممكن تدخل في غيبوبة، وممكن هذه تؤدي إلى الوفاة
+
+472
+00:37:26,950 --> 00:37:34,070
+إذا ماصار فيه يعني علاج بشكل عاجل. طيب، required
+
+473
+00:37:34,070 --> 00:37:36,610
+repeated intravenous infusion of glucose.  مازال في
+
+474
+00:37:36,610 --> 00:37:41,210
+hypoglycemia. بغض النظر عن السبب، المفروض طول ما في
+
+475
+00:37:41,210 --> 00:37:42,590
+الـ patient في hypoglycemia،
+
+476
+00:37:45,510 --> 00:37:50,330
+ينعطى  glucose. over the next 12 to 24 hours.
+
+477
+00:37:50,330 --> 00:37:55,170
+A sample of blood taken on admission was stored
+
+478
+00:37:55,170 --> 00:37:58,250
+and subsequently analyzed for insulin and C
+
+479
+00:37:58,250 --> 00:38:02,770
+-peptide. بياخدوا عينة ويحسّبوا يعني الدم الـ
+
+480
+00:38:02,770 --> 00:38:07,150
+result. يعني بياخدوا عينة، ممكن لاحقًا يشكوا أنه
+
+481
+00:38:07,150 --> 00:38:10,670
+في شيء معين في الدم وبالتالي العينة بتكون موجودة و
+
+482
+00:38:10,670 --> 00:38:15,720
+ممكن يفحصوها. تمام. يبقى من الفحوصات اللي عملوها، عملوا
+
+483
+00:38:15,720 --> 00:38:17,680
+انسولين وعملوا C-peptide. Result were
+
+484
+00:38:17,680 --> 00:38:22,440
+inappropriately raised. كان في عندنا ارتفاع في
+
+485
+00:38:22,440 --> 00:38:28,660
+الانسولين وفي الـ C-peptide. وهذا اللي هو السبب أن
+
+486
+00:38:28,660 --> 00:38:33,240
+في عندنا hypoglycemia. تمام. الارتفاع بالانسولين
+
+487
+00:38:33,240 --> 00:38:39,110
+تمام، أكيد ممكن يؤدي إلى اللي هو hypoglycemia. وهذا
+
+488
+00:38:39,110 --> 00:38:44,850
+اللي بيصير يعني في عندنا يعني بعض مرضى السكر مثلًا
+
+489
+00:38:44,850 --> 00:38:49,910
+اللي بياخدوا insulin. تمام، ممكن يصير في عندهم
+
+490
+00:38:49,910 --> 00:38:52,870
+hypoglycemia. طبعًا السبب ممكن يكون أنه أخذ جرعة
+
+491
+00:38:52,870 --> 00:38:58,870
+زائدة، أخذ الجرعة وما أكلش، أخذ الجرعة وما أكلش الفطور
+
+492
+00:38:58,870 --> 00:39:01,610
+اللي عادة بياكله، مثلًا اللي فيه كمية معينة من الـ
+
+493
+00:39:01,610 --> 00:39:05,590
+carbohydrates. ممكن يكون أخذ الجرعة وبدأ بمجهود
+
+494
+00:39:05,590 --> 00:39:10,790
+أكبر، تمام؟ يعني إيه؟ صار فيه مجهود أكبر، عادة بتمشي
+
+495
+00:39:10,790 --> 00:39:14,110
+يعني بذل مجهود؟ هذه ممكن كلها تؤدي إلى اللي هو
+
+496
+00:39:14,110 --> 00:39:20,190
+hypoglycemia. طيب، over the next few days repeated
+
+497
+00:39:20,190 --> 00:39:24,650
+overnight fasts failed to induce further
+
+498
+00:39:24,650 --> 00:39:26,090
+hypoglycemia.
+
+499
+00:39:27,790 --> 00:39:32,890
+يبقى يعني لأنه ما زال في عندنا زيادة في الـ
+
+500
+00:39:32,890 --> 00:39:35,810
+insulin وفي عندنا زيادة في الـ C-peptide. يبقى علاقة الـ
+
+501
+00:39:35,810 --> 00:39:41,330
+insulin إيش داخلي مظبوط. ما زال في C-peptide.
+
+502
+00:39:41,330 --> 00:39:46,730
+يبقى الـ insulin إيش داخلي وهي ما بتاخدش insulin، يعني
+
+503
+00:39:46,730 --> 00:39:51,380
+يبقى بشك أنه ممكن يكون في إيش؟ Insulinoma، تمام؟ في
+
+504
+00:39:51,380 --> 00:39:53,700
+عندنا ممكن cancer في الـ beta cells وفي إنتاج
+
+505
+00:39:53,700 --> 00:39:59,300
+بكميات كبيرة للانسولين. الآن هدول يعني عشان يشوفوا
+
+506
+00:39:59,300 --> 00:40:05,420
+أنه فعلا أن زيادة في الـ insulin بسبب الـ insulin
+
+507
+00:40:05,420 --> 00:40:10,140
+load. ما بيعملوا overnight fast، والمفروض أن يحصل
+
+508
+00:40:10,140 --> 00:40:14,320
+فيه hypoglycemia لو فعلا في زيادة insulin load.
+
+509
+00:40:14,320 --> 00:40:20,180
+Eventually، after a prolonged fast، في أربعة أيام،
+
+510
+00:40:20,180 --> 00:40:27,360
+الجلوكوز انخفض إلى 45. يعني في اليوم الرابع نزل
+
+511
+00:40:27,360 --> 00:40:33,520
+الجلوكوز لـ 45. في وقت ما الإنسولين وC-Peptide كانوا
+
+512
+00:40:33,520 --> 00:40:39,860
+غير ملحوظين، يعني ما كانش في عندنا الارتفاع في
+
+513
+00:40:39,860 --> 00:40:47,400
+الانسولين زي المرة الأولى. نتيجة الدراسة
+
+514
+00:40:51,830 --> 00:40:54,530
+هيبوغلايسيميا، ارتفاع في الإنسولين، وارتفاع في الـ C
+
+515
+00:40:54,530 --> 00:40:59,190
+-peptide، يدل كلّهم  يُشيرون إلى أنه في عندها زيادة في
+
+516
+00:40:59,190 --> 00:41:04,630
+إفراز الإنسولين. بيتالي كل كيلون إنسولين. طيب، هل هو
+
+517
+00:41:04,630 --> 00:41:07,530
+دليل قوي يدفعنا إلى أكثر حلقة من
+
+518
+00:41:07,530 --> 00:41:10,910
+الهيبوغلايسيميا؟ هذا ما قلنا، إن أكثر الأشخاص مع
+
+519
+00:41:10,910 --> 00:41:15,050
+إنسولينوما سيكونوا هيبوغلايسيميك على أحد أو أكثر
+
+520
+00:41:15,050 --> 00:41:21,290
+حلقات بعد ثلاث صيام عامة. لو صار فيه صوم overnight
+
+521
+00:41:21,290 --> 00:41:24,550
+صيام لمدة ثلاثة أيام إلا يصير في عندهم hypoglycemia
+
+522
+00:41:24,550 --> 00:41:28,990
+مرة ثانية. لكن هذه المريضة، صار في overnight صيام
+
+523
+00:41:28,990 --> 00:41:32,590
+لمدة ثلاثة أيام لكن ما صار فيه hypoglycemia. وباليوم
+
+524
+00:41:32,590 --> 00:41:39,750
+الرابع صار فيه انخفاض ونزل لـ 45. Even prolonged
+
+525
+00:41:39,750 --> 00:41:43,550
+fast failed to induce true hypoglycemia and at
+
+526
+00:41:43,550 --> 00:41:47,510
+that time insulin level was appropriately low. لم
+
+527
+00:41:47,510 --> 00:41:51,210
+يكنش فيه ارتفاع. Review of her history revealed no
+
+528
+00:41:51,210 --> 00:41:56,490
+suggestion of previous hypoglycemic episodes. تمام؟
+
+529
+00:41:56,490 --> 00:42:01,410
+كمان ما ظهرش يعني صار عندها hypoglycemia سابقًا.
+
+530
+00:42:01,410 --> 00:42:04,790
+Clinical staff were accordingly forced to
+
+531
+00:42:04,790 --> 00:42:08,630
+reconsider the initial diagnosis. يعني بعد هذه
+
+532
+00:42:08,630 --> 00:42:13,630
+الفحوصات اللي عملوها، رجعوا قالوا باحتمال عندها مرة
+
+533
+00:42:13,630 --> 00:42:14,710
+ثانية اللي هو Insulinoma.
+
+534
+00:42:23,340 --> 00:42:28,380
+العينة اللي احتفظوا فيها، رجعوا بعثوا يحللوها، and was
+
+535
+00:42:28,380 --> 00:42:30,660
+found to contain high concentrations of the oral
+
+536
+00:42:30,660 --> 00:42:37,340
+hypoglycemic drugs chlorpropamide و glibenclamide.
+
+537
+00:42:37,340 --> 00:42:43,720
+وهذه الـ drugs هم عبارة عن sulfonylurea.
+
+538
+00:42:45,250 --> 00:42:50,670
+الأدوية التي تعمل على زيادة إفراز
+
+539
+00:42:50,670 --> 00:42:54,850
+الإنسولين،  مفروض؟ مفروض أن الـ patient اللي كان فيه
+
+540
+00:42:54,850 --> 00:42:58,230
+hypoglycemia، يعطوه اللي هو الـ Sulfonylurea عشان
+
+541
+00:42:58,230 --> 00:43:01,850
+يزيدوا فقط إيش؟ من إفراز اللي هو الإنسولين اللي
+
+542
+00:43:01,850 --> 00:43:06,390
+عنده. طيب، these drugs Sulfonylurea which act by
+
+543
+00:43:06,390 --> 00:43:08,890
+enhancing pancreatic insulin secretion in response
+
+544
+00:43:08,890 --> 00:43:16,640
+to glucose.  هدول النوعين have long half-lives، الـ
+
+545
+00:43:16,640 --> 00:43:21,000
+half-life بتاعتهم إيش كمان؟ طويلة، making
+
+546
+00:43:21,000 --> 00:43:25,440
+hypoglycemia an occasional problem even when used
+
+547
+00:43:25,440 --> 00:43:28,580
+therapeutically in patients with diabetes.
+
+548
+00:43:33,600 --> 00:43:36,000
+طيب، ماذا يجب أن تحصل على هذه الأدوية؟ ممكن أن
+
+549
+00:43:36,000 --> 00:43:39,160
+تحصل أو تأخذ هذه الأدوية؟ لأننا قلنا لا قادرة
+
+550
+00:43:39,160 --> 00:43:43,120
+تأكل، ولا قادرة تشرب، ولا قادرة تعمل شيء. طب كيف هذه
+
+551
+00:43:43,120 --> 00:43:49,020
+الأدوية، ما زال الممرضين ما أعطوهاش؟ كيف وصلت ودخلت
+
+552
+00:43:49,020 --> 00:43:57,920
+جسمها؟ يبقى صار إيش؟ كأنه محاولة قتل. طيب، it was
+
+553
+00:43:57,920 --> 00:44:00,860
+likely that a relative distressed by her
+
+554
+00:44:00,860 --> 00:44:05,900
+condition. من الناس الأقارب اللي زاروها، حزنوا عليها،
+
+555
+00:44:05,900 --> 00:44:14,060
+شفوها بهذه الحالة، فواضح واحد إيش بده؟ يعني ينهي
+
+556
+00:44:14,060 --> 00:44:18,700
+حياتها. طيب، the police were informed that it was felt
+
+557
+00:44:18,700 --> 00:44:22,040
+that there was insufficient evidence to proceed.
+
+558
+00:44:22,040 --> 00:44:27,400
+الشرطة يعني صار في إغلاق القضية لعدم كفاية الأدلة.
+
+559
+00:44:27,400 --> 00:44:31,720
+زي ما بيحكوا. يعطيكم ألف عافية.
diff --git a/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/pTZfQgG5v8w_postprocess.srt b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/pTZfQgG5v8w_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..16c6f2e38c8b8567c73ceae33c04d4ae55f98d73
--- /dev/null
+++ b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/pTZfQgG5v8w_postprocess.srt
@@ -0,0 +1,2236 @@
+1
+00:00:02,160 --> 00:00:06,640
+Ten year old male presented to the emergency
+
+2
+00:00:06,640 --> 00:00:12,740
+department with recent history of polydipsia يبقى
+
+3
+00:00:12,740 --> 00:00:19,500
+طفل عمره عشر سنين ودخل اللي هو الاستقبال في
+
+4
+00:00:19,500 --> 00:00:28,200
+المستشفى وعنده اللي هو عطش fast polydipsiaبوليوريا
+
+5
+00:00:28,200 --> 00:00:36,820
+وفيه يعني frequent urination و vomiting on
+
+6
+00:00:36,820 --> 00:00:41,920
+admission blood specimens were collected for
+
+7
+00:00:41,920 --> 00:00:44,480
+routine chemistries and gases with the following
+
+8
+00:00:44,480 --> 00:00:52,020
+results بيأخذوا منه عينا وفحصوا ال electrolytes في
+
+9
+00:00:52,020 --> 00:00:55,730
+السودو و البوتاسيوم و الchlorideالسوديوم زي ما
+
+10
+00:00:55,730 --> 00:00:59,870
+واضح أنه فيه انخفاض مصيرته السوديوم البوتاسيوم
+
+11
+00:00:59,870 --> 00:01:05,810
+طبيعي الكلورايد برضه اللي هو منخفض ال total CO2
+
+12
+00:01:05,810 --> 00:01:15,350
+منخفض 14 اليوريا فيها ارتفاع في اليوريا وفي
+
+13
+00:01:15,350 --> 00:01:21,390
+الكرياتينين كمان كنا مرتفعين والجلوكوز مرتفع بشكل
+
+14
+00:01:21,390 --> 00:01:28,780
+كبير1063 milligram per deciliter و ال pH في عندنا
+
+15
+00:01:28,780 --> 00:01:33,220
+انخفاض في ال pH اللي هو 7.18 يعني في عندنا
+
+16
+00:01:33,220 --> 00:01:40,400
+acidosis موجود طبعا من ال من
+
+17
+00:01:40,400 --> 00:01:44,240
+اللي هو ال presentation لأ ال case طفل صغير عشر
+
+18
+00:01:44,240 --> 00:01:51,850
+سنين عمره السكر مرتفع بشكل كبيرعنا اللي هو الـ pH
+
+19
+00:01:51,850 --> 00:01:56,330
+من الخفضة طبعا، في عنده Acidosis والـ CO2 طبعا من
+
+20
+00:01:56,330 --> 00:02:01,550
+الخفضة فيعني غالبا الطفل هذا بعد الارتفاع الكبير
+
+21
+00:02:01,550 --> 00:02:04,590
+بالجلوكوز في عنده اللي هو الـ Type I Diabetes
+
+22
+00:02:04,590 --> 00:02:08,670
+Mellitus واحنا قولنا من ال complications اللي هو
+
+23
+00:02:08,670 --> 00:02:16,260
+ال acute يعني لـ Type I اللي بيصير في عنااللي هو
+
+24
+00:02:16,260 --> 00:02:22,220
+ketoacidosis بيصير فيه ketoacidosis يبقى انبين ان
+
+25
+00:02:22,220 --> 00:02:26,780
+الحالة هذه في عندنا اللي هو لبادة الـ ketoacidosis
+
+26
+00:02:26,780 --> 00:02:31,860
+الآن في اللباد الـ ketoacidosis ده several
+
+27
+00:02:31,860 --> 00:02:35,260
+metabolic arrangements في عندنا العديد من اللي هو
+
+28
+00:02:35,260 --> 00:02:37,660
+التغيرات اللي بتصير بما يتعلق بالـ metabolism
+
+29
+00:02:37,660 --> 00:02:44,140
+للكربوعيدرات لبروتينز لالـ lipidsبالنسبة لـ
+
+30
+00:02:44,140 --> 00:02:49,260
+Carbohydrates، علنا إذا الإنسلين موجود بشكل طبيعي،
+
+31
+00:02:49,260 --> 00:02:54,260
+الإنسلين يدفع إلى تغيير الجلوكوز وإيجلايكوجين
+
+32
+00:02:54,260 --> 00:03:00,180
+الهيباتيكي، إذا الإنسلين موجود، تمام؟ الآن في
+
+33
+00:03:00,180 --> 00:03:03,480
+الـDiabetic Ketoacidosis، انسفشن الإنسلين يسبب في
+
+34
+00:03:03,480 --> 00:03:06,930
+انهيبشة الإيجلايكوجين، مش موجود عند الإنسليناللي
+
+35
+00:03:06,930 --> 00:03:11,830
+فعلياً لجلوكوز مافيش إشي اللي يدخله إلى داخل
+
+36
+00:03:11,830 --> 00:03:15,410
+الخلايا عشان هيك زي ما شوفنا الجلوكوز مرتفع بشكل
+
+37
+00:03:15,410 --> 00:03:21,650
+كبير في البلازمة 1260 وبالتالي اللي هو الـ
+
+38
+00:03:21,650 --> 00:03:26,090
+hyperglycemia اللي بشكل كبير الموجودة بالنسبة للـ
+
+39
+00:03:26,090 --> 00:03:32,430
+limitمتابوليزم انسلين برضه يفتح ليبوجينيسيا إذا
+
+40
+00:03:32,430 --> 00:03:36,850
+الانسلين موجود برضه بيعمل هو طبعا اللي هو تصنيع
+
+41
+00:03:36,850 --> 00:03:41,670
+الدهون و induction لتصنيع الدهون لكن في ال DKA
+
+42
+00:03:41,670 --> 00:03:45,530
+insufficient insulin leads to lipolysis with the
+
+43
+00:03:45,530 --> 00:03:50,710
+production of glycerol and fatty acids لأن ما زال
+
+44
+00:03:50,710 --> 00:03:56,050
+الانسلين مش موجود تمام بيصير في عندنا الورليز ل
+
+45
+00:03:57,680 --> 00:04:01,440
+الجلوكوز من الكبت يعني عن طريق اللي هو
+
+46
+00:04:01,440 --> 00:04:04,880
+glucogenolysis والجلوكو نيوجينيسيس تمام لأن
+
+47
+00:04:04,880 --> 00:04:08,380
+الجلوكو نيوجينيسيس عندنا اللي هو طبعا يعني تصنيع
+
+48
+00:04:08,380 --> 00:04:11,660
+الجلوكوز from non-carbohydrate sources زي اللي هو
+
+49
+00:04:11,660 --> 00:04:15,700
+الليبت وايضا زي البروتينز تمام؟ يعني بيصير في
+
+50
+00:04:15,700 --> 00:04:21,600
+عندنا ليبوليزيز وبيصير طبعا اللي هو إنتاج لجليسرول
+
+51
+00:04:21,600 --> 00:04:26,160
+وفات الأسدوالـ Fatty acids are further metabolized
+
+52
+00:04:26,160 --> 00:04:30,420
+for energy هبص فينا Oxidation لـ الـ Fatty acids
+
+53
+00:04:30,420 --> 00:04:35,840
+وبينتجهان عندنا الـ Ketones المختلفة الـ Beta
+
+54
+00:04:35,840 --> 00:04:39,560
+-hydroxybutyrate وعندنا الـ Acetostate وعندنا
+
+55
+00:04:39,560 --> 00:04:46,260
+أيضًا برضه الـ Acetone فهدول التلاتة Ketoneأو الـ
+
+56
+00:04:46,260 --> 00:04:49,440
+Ketones اللي بينتجوا عندنا أيضًا الـ Deranged
+
+57
+00:04:49,440 --> 00:04:53,800
+Protein Metabolism برضه Insufficient Insulin Leads
+
+58
+00:04:53,800 --> 00:04:56,580
+to Proteolysis زي ما قلنا لأن فيه Gluconeogenesis
+
+59
+00:04:56,580 --> 00:05:00,920
+حيصير وبالتالي بيصير عندنا Breakdown لبروتينز عشان
+
+60
+00:05:00,920 --> 00:05:07,140
+يتم استخدام الـ Amino Acids في الحصول على طاقة
+
+61
+00:05:07,140 --> 00:05:10,500
+ويبقى
+
+62
+00:05:10,500 --> 00:05:12,920
+Leads to Proteolysis الـ Negative Nitrogen Balance
+
+63
+00:05:13,770 --> 00:05:17,570
+بيصير Negative Nitrogen Balance بشكل طبيعي بيكون
+
+64
+00:05:17,570 --> 00:05:24,630
+فينا الـ Nitrogen الداخل يتطالع لأن في هذه الحالة
+
+65
+00:05:24,630 --> 00:05:27,850
+بيصير فينا Negative Nitrogen Balance إيش يعني؟
+
+66
+00:05:27,850 --> 00:05:33,710
+يعني بيصير فينا اللي طالع أكتر من اللي داخل طيب
+
+67
+00:05:33,710 --> 00:05:37,050
+برضه اللي بيصير فينا Electrolyte Imbalances
+
+68
+00:05:37,050 --> 00:05:40,790
+Hyperglycemia may lead to osmotic dialysis and
+
+69
+00:05:40,790 --> 00:05:47,130
+urinary sodium lossلأن الجلوكوز أزموتيكي أكتر،
+
+70
+00:05:47,130 --> 00:05:55,170
+يعني لو أنا عندي جلوكوز، فيه عندنا الميّه، زي الـ
+
+71
+00:05:55,170 --> 00:06:00,610
+Sodium مثلا برضه، يبدأ
+
+72
+00:06:00,610 --> 00:06:04,390
+عندنا الآن لما بيصير، يرتفع، زي ما شوفنا عندنا
+
+73
+00:06:04,390 --> 00:06:10,970
+ارتفاع بشكل كبيرللـ Glucose وزي ما انتوا عارفين ان
+
+74
+00:06:10,970 --> 00:06:15,270
+الـ threshold لـ Glucose Reabsorption في الكدني هو
+
+75
+00:06:15,270 --> 00:06:20,210
+تقريبا 180 يبقى عندنا 1260 يبقى أكيد في عندنا خروج
+
+76
+00:06:20,210 --> 00:06:26,230
+لكميات كبيرة من ال glucose عن طريق ال urine ومازال
+
+77
+00:06:26,230 --> 00:06:29,370
+osmotically active يبقى هيطلع معاه كمان أيش كميات
+
+78
+00:06:29,370 --> 00:06:32,410
+كبيرة من الميه عشان هيك عند هذا الطفل كان في
+
+79
+00:06:32,410 --> 00:06:36,930
+polyuria في اللي هو urination بشكل اللي هو كبيرو
+
+80
+00:06:36,930 --> 00:06:41,230
+هذا اللي أدى إلى الواء ال polydipsy حدوث الوثاسة
+
+81
+00:06:41,230 --> 00:06:47,370
+لأنه لما بيفقد كميات كبيرة من الميه هذا هيغير من
+
+82
+00:06:47,370 --> 00:06:52,110
+الواء ال osmolality تمام؟ وبالتالي هيصير فيه إحساس
+
+83
+00:06:52,110 --> 00:06:59,470
+في العطش عند هذا الطفلده Sodium Depletion لان اذا
+
+84
+00:06:59,470 --> 00:07:02,530
+بقولنا بيصير في عنا برضه Sodium Loss Sodium
+
+85
+00:07:02,530 --> 00:07:06,410
+Depletion father worsened by vomiting كمان ال
+
+86
+00:07:06,410 --> 00:07:09,450
+vomiting اللي عند هذا الطفل برضه هذا زاد مشكلة
+
+87
+00:07:09,450 --> 00:07:14,810
+اللي هو فقدان Sodium عند الطفلHowever,
+
+88
+00:07:14,930 --> 00:07:20,010
+hypermetribia is a common finding in DTA بحيث أن
+
+89
+00:07:20,010 --> 00:07:25,010
+الصوديوم منخفض لكن ممكن في حالات أخرى نلاقي أن
+
+90
+00:07:25,010 --> 00:07:30,190
+الصوديوم مرتفع، common finding when dehydration
+
+91
+00:07:30,190 --> 00:07:37,770
+predominates over sodium lossلأن هنا في عندي فقد
+
+92
+00:07:37,770 --> 00:07:42,370
+لسوائل بكمية كبيرة الان في عندي فقد للسوديوم لكن
+
+93
+00:07:42,370 --> 00:07:49,570
+فقد الميه أكبر من فقد السوديوم تمام؟ وبالتالي كمية
+
+94
+00:07:49,570 --> 00:07:55,170
+السوديوم الموجودة عندى تمام؟ بتصير دايبة في كمية
+
+95
+00:07:55,170 --> 00:07:59,630
+أقل من الميه يبقى ال concentration بترتفع تمام؟
+
+96
+00:07:59,630 --> 00:08:04,990
+الجهة اللي في عندنا اللي هو relativeIncrease يعني
+
+97
+00:08:04,990 --> 00:08:07,950
+زي كان عندى ال Sodium كمية Sodium مثلا على سبيل
+
+98
+00:08:07,950 --> 00:08:16,190
+المثال واحد اجرام دايبة مثلا في لتر الآن صار عندى
+
+99
+00:08:16,190 --> 00:08:22,110
+point تسعة اجرام دايب في نص لتريبقى صار فيه أن دي
+
+100
+00:08:22,110 --> 00:08:25,250
+فقد لأ الميه كمية كبيرة فقد للصوديوم لكن مقاومة
+
+101
+00:08:25,250 --> 00:08:30,090
+بالميه أقل يبقى هذا أدى إلى ارتفاع في الواقع أو
+
+102
+00:08:30,090 --> 00:08:32,910
+بيأد يعني عادة إلى ارتفاع في ال sodium
+
+103
+00:08:32,910 --> 00:08:36,230
+concentration لكن زي ما قلنا هان الحالة أنه في
+
+104
+00:08:36,230 --> 00:08:39,990
+vomiting ف ال vomiting هذا كمان أدى إلى فقد لأ
+
+105
+00:08:39,990 --> 00:08:43,370
+الصوديوم لأن كان فيه أن الصوديوم شويه أقل من
+
+106
+00:08:43,370 --> 00:08:47,590
+الطبيعةأسيدوزيات مرتبطة مع الـDKA تسبب في تغيير
+
+107
+00:08:47,590 --> 00:08:52,350
+البوتاسيوم بشكل أكتر بشكل سلوكي يتسبب في تغيير
+
+108
+00:08:52,350 --> 00:08:58,230
+الهيبركاليميا الان من ميكانيزات التغيير
+
+109
+00:08:58,230 --> 00:09:06,070
+للأسيدوزيات أن بيصير في عندي تغيير للبوتاسيوم لما
+
+110
+00:09:06,070 --> 00:09:11,370
+يكون في عندي أسيدوزيات بيصير فيه دخول للهيدرين
+
+111
+00:09:11,370 --> 00:09:17,730
+أيون إلى داخل الـred blood cellsعشان نقلل من الـ
+
+112
+00:09:17,730 --> 00:09:21,930
+hydrogen ions الموجودة في البلازمة يعني نحاول نعدل
+
+113
+00:09:21,930 --> 00:09:25,710
+من الانخفاض في الـ pH اللي صار يبقى الـ hydrogen
+
+114
+00:09:25,710 --> 00:09:30,090
+ions بتدخل إلى داخل الـ red blood cellsطبعا كما
+
+115
+00:09:30,090 --> 00:09:33,530
+تعرفون أن هناك الـ Electric Neutrality يعني دائما
+
+116
+00:09:33,530 --> 00:09:37,030
+يجب أن يكون عندي عدد الـ Ions الموجة ما بيساوي عدد
+
+117
+00:09:37,030 --> 00:09:39,950
+ال Ions السالبة، يبقى إذا كانت خلال الـ Hydrogen
+
+118
+00:09:39,950 --> 00:09:43,070
+Ions اللي موجة إلى داخل الخلية، يبقى لازم يطلع
+
+119
+00:09:43,070 --> 00:09:46,830
+عندي اللي هو Positive Ion، أيش اللي بيطلع؟ الـ
+
+120
+00:09:46,830 --> 00:09:52,110
+Potassium اللي بيطلع، تمام؟يدخل هيدروجين آيون
+
+121
+00:09:52,110 --> 00:09:55,390
+وبالتالي بنقلل من الهيدروجين آيون وبالتالي بنحسن
+
+122
+00:09:55,390 --> 00:10:00,310
+من البيئات وبطلع عندي اللي هو بوتاسيوم however
+
+123
+00:10:00,310 --> 00:10:03,830
+because potassium is also lost renally and extra
+
+124
+00:10:03,830 --> 00:10:08,370
+renally total body potassium is often depleted لأن
+
+125
+00:10:08,370 --> 00:10:12,010
+برضه بهذا الحالة كان أن البوتاسيوم طبيعي
+
+126
+00:10:12,010 --> 00:10:17,590
+البوتاسيوم 75.2طبعا، لكن يعني برضه ممكن يكون فيه
+
+127
+00:10:17,590 --> 00:10:20,410
+عندنا hyperkalemia لكن زي ما قلنا إنه في عندنا
+
+128
+00:10:20,410 --> 00:10:25,730
+loss للبوتاسيوم عن طريق ال kidney وعندنا برضه عن
+
+129
+00:10:25,730 --> 00:10:30,310
+طريق ال vomiting وبالتالي يعني ماكانش عندنا ارتفاع
+
+130
+00:10:30,310 --> 00:10:32,030
+في البوتاسيوم، كان البوتاسيوم ال concentration
+
+131
+00:10:32,030 --> 00:10:38,000
+تبعته اللي هو طبيعيالأن هناك ملاحظة أن هذه الحالات
+
+132
+00:10:38,000 --> 00:10:41,900
+أن الشكر مرتفع بشكل كبير لأن من العلاج اللي بيعطوه
+
+133
+00:10:41,900 --> 00:10:47,080
+لهذا المريض لازم يعطوه insulin تمام؟ عشان يخفضوا
+
+134
+00:10:47,080 --> 00:10:51,560
+من مستوى السكر الآن المشكلة أن ال insulin therapy
+
+135
+00:10:51,560 --> 00:11:01,400
+هذه ممكن تؤدي إلى hypokalemiaلأن الإنسولين يزيد من
+
+136
+00:11:01,400 --> 00:11:04,840
+دخول البوتاسيوم إلى داخل الخلايا
+
+137
+00:11:09,780 --> 00:11:13,240
+الدخول اللي هو الـ Potassium بيزيد من اللي هو الـ
+
+138
+00:11:13,240 --> 00:11:17,140
+ATP اللي هو الـ Sodium Potassium Bump Activity
+
+139
+00:11:17,140 --> 00:11:20,600
+وبالتالي بيزيد من دخول الـ Potassium إلى داخل
+
+140
+00:11:20,600 --> 00:11:24,660
+الخلية وبالتالي ممكن مع العلاج اللي يُعطيها بيشير
+
+141
+00:11:24,660 --> 00:11:28,660
+بيكون فيه مراقبة مستمرة للمريض لأن هذا ممكن يؤدي
+
+142
+00:11:28,660 --> 00:11:30,760
+إلى حدوث Hypo-Kelling
+
+143
+00:11:32,850 --> 00:11:36,170
+بالإضافة إلى البوتاسيوم، الفوسفات أيضًا تتحرك بشكل
+
+144
+00:11:36,170 --> 00:11:42,350
+إنتراليوني لتعامل مع الإنسلين وبالتالي برضه ممكن
+
+145
+00:11:42,350 --> 00:11:46,010
+أن يكون هناك انخفاض في البوتاسيوم وهيبوفسفوتيميا
+
+146
+00:11:46,010 --> 00:11:49,990
+يبقى أثناء العلاج لابد من المراقبة المستمرة
+
+147
+00:11:49,990 --> 00:11:56,200
+لإلكتروليتز عند المرضىطبعا هنا برضه من الشغلات
+
+148
+00:11:56,200 --> 00:11:59,680
+اللي بتتأثر عندنا اللي هو الـ acid-base balance زي
+
+149
+00:11:59,680 --> 00:12:04,120
+ما شفنا أن البيئة كانت منخفض كان في عندنا اللي هو
+
+150
+00:12:04,120 --> 00:12:07,840
+الـ Acidosis production of ketoacids in BKA causes
+
+151
+00:12:07,840 --> 00:12:13,760
+high anion gap metabolic acidosis with beta
+
+152
+00:12:13,760 --> 00:12:17,480
+hydroxybutyrate more abundant than acetoacetate
+
+153
+00:12:18,920 --> 00:12:22,380
+يبقى .. زي ما قلنا أنه عندنا بيصير ليبوليزيز بيصير
+
+154
+00:12:22,380 --> 00:12:25,880
+فيه الـ oxidation لفتي أسد بيصير عندنا إنتاج
+
+155
+00:12:25,880 --> 00:12:31,960
+لكيتون أسد أو الكيتون أسد هذه اللي بيصير في عندنا
+
+156
+00:12:31,960 --> 00:12:38,260
+أو بتلعب دور في انخفاض الـ pH وزيادة الـ hydrogen
+
+157
+00:12:38,260 --> 00:12:46,680
+ions في عندنا اللي هو causes high anion gapحنحكي
+
+158
+00:12:46,680 --> 00:12:49,520
+عن الـ Anions جاب لما نحكي عن الـ Electrolytes لأن
+
+159
+00:12:49,520 --> 00:12:54,800
+الـ Anions جاب عبارة عن الـ Unmeasured
+
+160
+00:12:54,800 --> 00:12:59,560
+anions مطروح منها الـ Unmeasured كتائز و المفروض
+
+161
+00:12:59,560 --> 00:13:04,780
+تكون يعني في إليها reference interval معين إبداعا
+
+162
+00:13:04,780 --> 00:13:09,080
+يكون فينا ارتفاع في الـ Anions جاب لأن صار فينا
+
+163
+00:13:09,080 --> 00:13:15,870
+زيادة في الـ Anions الموجودة عند المريضطيب الـ
+
+164
+00:13:15,870 --> 00:13:19,650
+Lactic Acid برضه production اللي ممكن برضه تزيد
+
+165
+00:13:19,650 --> 00:13:25,750
+بسبب الورفور سيركليشن and شوكر هذه برضه اللي ممكن
+
+166
+00:13:25,750 --> 00:13:30,230
+تزيد من ال metabolic acidولي changes in urea و
+
+167
+00:13:30,230 --> 00:13:33,170
+الكريتالين لأن زى ما شوفنا فيها ان ارتفاع في اليرة
+
+168
+00:13:33,170 --> 00:13:37,490
+و الكريتالين طبعا ليش لأنهازي ما شوفنا انه في
+
+169
+00:13:37,490 --> 00:13:41,830
+dehydration في فقد الكيميات الكبيرة من الميه يبقى
+
+170
+00:13:41,830 --> 00:13:47,910
+عند ال blood volume قلق صحيح؟ يبقى في هذه الحالة
+
+171
+00:13:47,910 --> 00:13:54,150
+في عندنا الـ Prerenal Azotemia زي ما انتوا عارفين
+
+172
+00:13:54,820 --> 00:13:59,400
+اللي هو الارتفاع في اليولياء في تلت أسباب فيها
+
+173
+00:13:59,400 --> 00:14:01,460
+اللي هو الـ pre-renal و الرينال و ال post-renal
+
+174
+00:14:01,460 --> 00:14:06,700
+طبعا حالات اللي هو النقص في blood volume أو إذا
+
+175
+00:14:06,700 --> 00:14:10,060
+كان في عنا مشكلة في القلب وبالتالي يعني تضافة
+
+176
+00:14:10,060 --> 00:14:15,940
+قدامها ده بيعمللي ما يسمى بـ pre-renal أزوتيميا
+
+177
+00:14:17,320 --> 00:14:20,100
+الـ Extremely High Plasma Concentrations of
+
+178
+00:14:20,100 --> 00:14:23,180
+Ketones May Cause Positive Interference In Some
+
+179
+00:14:23,180 --> 00:14:27,420
+Laboratory Methods For Measuring Creatinine كمان
+
+180
+00:14:27,420 --> 00:14:31,560
+الارتفاع في الـ Ketones حتى الارتفاع بالجلوكوز
+
+181
+00:14:31,560 --> 00:14:39,480
+ممكن يعمل interferenceفيه الوالجافي method لفحص
+
+182
+00:14:39,480 --> 00:14:43,000
+الكرياتينينة اذا ما تعرفين ان في عندنا ممكن
+
+183
+00:14:43,000 --> 00:14:46,620
+interference في بعض الفحصات اشي بيأثر على اشي زي
+
+184
+00:14:46,620 --> 00:14:51,160
+hemolysis مثلا زي لو الليبيليا زيادة الليبيدز ممكن
+
+185
+00:14:51,160 --> 00:14:54,920
+تأثر على بعض الفحصات اه بجهان باليروبيل بجهان في
+
+186
+00:14:54,920 --> 00:14:58,980
+عندنا الزيادة في ال ketone bubbles و ال glucose
+
+187
+00:14:58,980 --> 00:15:05,430
+هيأثر على الفحص الكرياتينيهذا الفيجور يوضح أن
+
+188
+00:15:05,430 --> 00:15:08,950
+الأمور
+
+189
+00:15:08,950 --> 00:15:12,910
+المختلفة اللي بتتغير على مستوى اللي هو الـ
+
+190
+00:15:12,910 --> 00:15:16,510
+Endocrine في أنها طبعاً زي ما مازال الـ Type 1
+
+191
+00:15:16,510 --> 00:15:20,930
+يبقى Absolute Deficiency وإنسلين وبالتالي هذا
+
+192
+00:15:20,930 --> 00:15:23,850
+بيقدر إلى ارتفاع في ال counter regulatory hormones
+
+193
+00:15:23,850 --> 00:15:28,490
+زي ما قلنا إن بيصير فينا زيادةفي اللواء الـ
+
+194
+00:15:28,490 --> 00:15:32,530
+hyperglycemic hormones زي الـ glucagon و زي اللواء
+
+195
+00:15:32,530 --> 00:15:35,390
+الـ hormones الأخرى الآن الـ metabolic
+
+196
+00:15:35,390 --> 00:15:38,230
+abnormalities على مستوى الـ carbohydrates بيصير
+
+197
+00:15:38,230 --> 00:15:40,850
+فيها زيادة في الـ glucogenolysis و بيصير فيها
+
+198
+00:15:40,850 --> 00:15:45,450
+زيادة في الـ gluconeogenesis بالإضافة للانخفاض في
+
+199
+00:15:45,450 --> 00:15:50,530
+الـ glucose uptake تمام؟ و هذه كلها طبعا بالنهاية
+
+200
+00:15:50,530 --> 00:15:53,210
+بتؤدي إلى hyperglycemia
+
+201
+00:15:54,700 --> 00:15:59,060
+عنا على مستوى البروتينز اللي بتزيد اللي هو
+
+202
+00:15:59,060 --> 00:16:03,140
+البروتيولوجيز تمام؟ وبالتالي هذا بيزيد من ال
+
+203
+00:16:03,140 --> 00:16:08,420
+plasma amino acid عنا الفات بيزيد ال lipolysis و
+
+204
+00:16:08,420 --> 00:16:11,480
+برضه بيزيد ال ketogenesis اللي هو production of
+
+205
+00:16:11,480 --> 00:16:16,880
+ketoneوبالتالي هذا بيزيد من البلازمة اللي وفّيه
+
+206
+00:16:16,880 --> 00:16:20,520
+fatty acids وبيزيد أيضًا من ال ketone bodies
+
+207
+00:16:20,520 --> 00:16:23,860
+التغيرات اللي بتصير بالبلازمة زي ما قلنا
+
+208
+00:16:23,860 --> 00:16:27,480
+hyperglycemia بتزيد عندنا اللي هو البلازمة
+
+209
+00:16:27,480 --> 00:16:31,120
+osmolality لأن عندنا زي ما قلنا ال glucose
+
+210
+00:16:31,120 --> 00:16:34,300
+osmetically active وبالتالي بيزيد عندنا اللي هو
+
+211
+00:16:34,300 --> 00:16:40,900
+البلازمة osmolalityبتزيد الـ Amino Acids وبتزيد
+
+212
+00:16:40,900 --> 00:16:45,160
+برضه إن ما زال الـ Amino Acids زادت يبقى عندنا
+
+213
+00:16:45,160 --> 00:16:49,540
+اليوريا برضه هتزيد و هذا سبب آخر لزيادة اليوريا
+
+214
+00:16:49,540 --> 00:16:54,160
+غير الـ dehydrationإنه قوية اللي هو الـ prelineal
+
+215
+00:16:54,160 --> 00:16:57,260
+azotemia يعني صار فينا زيادة في البلازمة أمانو أسس
+
+216
+00:16:57,260 --> 00:17:00,020
+وبالتالي زي ما انتوا عارفين بلازمة اللي أمانو أسس
+
+217
+00:17:00,020 --> 00:17:04,420
+ماتتخزنش إذا فينا surplus بيصلها إيش break down و
+
+218
+00:17:04,420 --> 00:17:07,980
+ال break down للأمانو أسس إيش بينتج عنه؟ بينتج عنه
+
+219
+00:17:07,980 --> 00:17:12,400
+اللي هو يوريا زيادة بيه اللي هو البلازمة فيه فاتق
+
+220
+00:17:12,400 --> 00:17:16,940
+أسس وزيادة برضه بيه ال ketone bodies طيب ال
+
+221
+00:17:16,940 --> 00:17:21,500
+physiological consequencesالـ Hyperglycemia ستعمل
+
+222
+00:17:21,500 --> 00:17:27,600
+لـ Glucosuria سيكون هناك خروج لجلوكوز عن طريق
+
+223
+00:17:27,600 --> 00:17:32,360
+اليورين وهنا سيكون هناك Osmotic Diarsis سنقول أن
+
+224
+00:17:32,360 --> 00:17:35,420
+الجلوكوز أسمه Osmotically Active سيكون هناك خروج
+
+225
+00:17:35,420 --> 00:17:38,740
+لكميات كبيرة من الجلوكوز وهذا سيسحب معاه كميات
+
+226
+00:17:38,740 --> 00:17:44,340
+كبيرة من الميه في اليورين أيضا وهذا برضه سيؤدي إلى
+
+227
+00:17:44,340 --> 00:17:48,840
+فقد وسيعمل لنا Unbalance لأنه يصبح فقد لإلكترولايت
+
+228
+00:17:50,670 --> 00:17:55,370
+وبالنهاية سيصبح هناك hypovolemia انقفاض في blood
+
+229
+00:17:55,370 --> 00:17:59,950
+volume وبالتالي الهو dehydration ال plasma
+
+230
+00:17:59,950 --> 00:18:04,510
+osmolality اللى صارت في البلازمة زى ما تعرفين ال
+
+231
+00:18:04,510 --> 00:18:09,010
+hypothalamus مستجيل لل osmolality اللى في الدم لأن
+
+232
+00:18:09,010 --> 00:18:13,820
+لما بزيد هنا ال osmolality ال hypothalamusالمفروض
+
+233
+00:18:13,820 --> 00:18:18,080
+ايش بيعمل؟ اللي هو بزيد من إفراز الـ antihydrated
+
+234
+00:18:18,080 --> 00:18:23,060
+hormone عشان يصبح عنده more absorption للميّه
+
+235
+00:18:23,060 --> 00:18:29,180
+وبيعطي إحساس بالعطش يبقى هان في عندنا اللي هو
+
+236
+00:18:29,180 --> 00:18:35,600
+thirst هان اللي في عندنا يوريميا اللي هو ارتفاع في
+
+237
+00:18:35,600 --> 00:18:49,100
+مستوى اليوريا والـhypovolemia اللي صاربالتالي قلل
+
+238
+00:18:49,100 --> 00:18:54,340
+من الـ Glomerular Filtration Rate وكما تعرفون كلما
+
+239
+00:18:54,340 --> 00:18:59,120
+قلت Glomerular Filtration Rate كل معناه ما الـ
+
+240
+00:18:59,120 --> 00:19:02,580
+Substances المختلفة اللي بيستخدم ال filtration قلت
+
+241
+00:19:02,580 --> 00:19:08,870
+وبالتالي حصل ارتفاع في إدامإنخفاض في الـ Renal
+
+242
+00:19:08,870 --> 00:19:12,610
+Hydrogen Execration وبرضه إنخفاض في الـ Glomeral
+
+243
+00:19:12,610 --> 00:19:17,590
+Filtration Rate هذا قلل من الـ Hydrogen Ion
+
+244
+00:19:17,590 --> 00:19:21,350
+Execration لأنه المفروض أنا لما برتفع عندي الـ
+
+245
+00:19:21,350 --> 00:19:25,930
+Hydrogen Ions في الدم المفروض بيصير في عندي more
+
+246
+00:19:25,930 --> 00:19:30,240
+Execration of Hydrogen Ionsالأن مع انخفاض اللي حصل
+
+247
+00:19:30,240 --> 00:19:34,020
+في الـ Glucose Reception Rate بجهة أقل من الـ
+
+248
+00:19:34,020 --> 00:19:36,340
+Execretion اللي لها الـ hydrogen ions و برضه ساعد
+
+249
+00:19:36,340 --> 00:19:44,080
+في حدوث الـ Acidoses بالإضافة لكيتوناتالتي ارتفعت
+
+250
+00:19:44,080 --> 00:19:50,640
+و الـ Ketones برضه أست وبالتالي برضه بتزيد من ال
+
+251
+00:19:50,640 --> 00:19:53,440
+release ال hydrogen ions وبالتالي بتلعب دور في ال
+
+252
+00:19:53,440 --> 00:19:58,780
+acidoses اللي صارت طيب في المرضى هدول اللي بيكون
+
+253
+00:19:58,780 --> 00:20:02,560
+عندهم ketoacidoses لو جينا جربنا و شمينا النفس
+
+254
+00:20:02,560 --> 00:20:09,370
+بتاعهم بنجد نفس فرووتي هيك فيه ريحة عطرة حلوةالسبب
+
+255
+00:20:09,370 --> 00:20:12,770
+هو الـ Ketone Body برضه اللي هو الـ Acetone اللي
+
+256
+00:20:12,770 --> 00:20:17,830
+بيسمله Exhalation أو خروج مع اللي هو الزفير
+
+257
+00:20:17,830 --> 00:20:23,070
+الارتفاع في الـ Ketone Bodies برضه ممكن هو اللي
+
+258
+00:20:23,070 --> 00:20:27,490
+عمل الـ Vomiting هو سبب الـ Vomiting تمام؟ لأن الـ
+
+259
+00:20:27,490 --> 00:20:31,290
+Ketones عبارة عن اللي هو Updated Subresence
+
+260
+00:20:31,290 --> 00:20:38,920
+وبيؤدوا إلى نوزياوبالتالي الـ vomiting هو سبب
+
+261
+00:20:38,920 --> 00:20:45,060
+الارتفاع في الكيوتون باطسي بالنسبة للـ Acidoses
+
+262
+00:20:45,060 --> 00:20:48,460
+احنا قلنا انه صار في انا Acidoses الان هدول
+
+263
+00:20:48,460 --> 00:20:54,140
+الأشخاص بيكون فيه النفس عندهم سريع اللي بيصير فيه
+
+264
+00:20:54,140 --> 00:20:56,080
+hyperventilation
+
+265
+00:20:59,350 --> 00:21:02,610
+سبب الـ hyperventilation هي عبارة عن الـ
+
+266
+00:21:02,610 --> 00:21:07,710
+compensation mechanism لأننا سنحكي عليها بالتفصيل
+
+267
+00:21:07,710 --> 00:21:11,370
+هذه لما نحكي على الـ acid imbalance لما يكون لدي
+
+268
+00:21:11,370 --> 00:21:14,830
+متابولك أسيدوزيز ماهو ال compensation mechanism
+
+269
+00:21:14,830 --> 00:21:20,630
+بتكون عن طريق الجهاز اللي مش مصابب، في هذه الحالة
+
+270
+00:21:20,630 --> 00:21:24,670
+بتكون ال lungs يتجه ال lungs بتعمل ال compensation
+
+271
+00:21:24,670 --> 00:21:31,480
+بتحاول التعدلمن اللي هو الـ pH طبعا هذا عندنا اللي
+
+272
+00:21:31,480 --> 00:21:34,920
+هو في المعادلة بحثت عنها مرة عليك بالصدق انها لأ
+
+273
+00:21:34,920 --> 00:21:43,580
+الان احنا عندنا ال CO2 مع ال H2O بيعطيني H2CO3 هذا
+
+274
+00:21:43,580 --> 00:21:48,540
+بصيرله اللي هو تحليل لHCO3 و hydrogen ions طيب
+
+275
+00:21:48,540 --> 00:21:53,380
+الان لما انا بتفت عندى ال hydrogen ions طيب هنا
+
+276
+00:21:53,380 --> 00:22:04,190
+عندنا ال H2Oمع الـ CO2 قالوا بيعطينا H2CO3 هذي
+
+277
+00:22:04,190 --> 00:22:10,870
+بيصير لها الassociation لـ HCO3 و Hydrogen اللي هو
+
+278
+00:22:10,870 --> 00:22:16,650
+Iكمبنسيشن ميكانيزم لما يحدث فينا ارتفاع في الـ
+
+279
+00:22:16,650 --> 00:22:20,630
+hydrogen ions يحدث فيه hyperventilation ماهو
+
+280
+00:22:20,630 --> 00:22:24,690
+hyperventilation؟ يعني معدل التنفس بيزيد تمام؟ لما
+
+281
+00:22:24,690 --> 00:22:28,730
+معدل التنفس بيزيد، ماذا يحدث فينا؟ more exhalation
+
+282
+00:22:28,730 --> 00:22:33,390
+of CO2 يحدث فينا فقط لكميات أكبر من الـCO2، إذا
+
+283
+00:22:33,390 --> 00:22:40,020
+ماهو حدث لـCO2؟هينخفض تمام؟ هينزل لأن لما بنزل الـ
+
+284
+00:22:40,020 --> 00:22:44,440
+CO2 بيصير في عندنا المعادلة بتمشي بهذا الاتجاه
+
+285
+00:22:44,440 --> 00:22:52,020
+يبقى بيصير في عندي hydrogen ions ترتبط مع HCO3عشان
+
+286
+00:22:52,020 --> 00:22:55,800
+يعطينا H2CO3 عشان نعود اللي هو النقص اللي بالـCO2
+
+287
+00:22:55,800 --> 00:23:00,220
+اللي جاعد الجسم بتخلص منه يبقى احنا إيش بنعمل؟
+
+288
+00:23:00,220 --> 00:23:05,160
+جاعدين نتخلص من الـhydrogen ions الموجودة في
+
+289
+00:23:05,160 --> 00:23:12,400
+البلازمة طيب الكاسد التانية عنا
+
+290
+00:23:12,400 --> 00:23:18,080
+a 27 year old man was referred to the local
+
+291
+00:23:18,080 --> 00:23:22,630
+diabetic clinicيبقى الشاب عمره 27 سنة he had been
+
+292
+00:23:22,630 --> 00:23:26,590
+diagnosed as having type 2 diabetes malatus يعني
+
+293
+00:23:26,590 --> 00:23:31,690
+عنده ارتفاع في السكرويعني من الفحوصات اللي قاملوها
+
+294
+00:23:31,690 --> 00:23:34,070
+توصلوا إنه عنده type 2 diabetes myelitis three
+
+295
+00:23:34,070 --> 00:23:38,010
+years previously and his control was poor يعني
+
+296
+00:23:38,010 --> 00:23:42,330
+كانت تلت سنين له وتحكمه بالجلوكوز يعني مستويات
+
+297
+00:23:42,330 --> 00:23:46,710
+الجلوكوز دايما عنده إيش مرتفعة و الدليل إنه هي
+
+298
+00:23:46,710 --> 00:23:53,450
+عندنا برضه ال hemoglobin A1C 9.6% despite being on
+
+299
+00:23:53,450 --> 00:23:58,050
+an optimal dose of metforminالعلاج اللي كان بياخده
+
+300
+00:23:58,050 --> 00:24:03,170
+هذا المريض هو ال medformin طبعا هو المرضى السكري
+
+301
+00:24:03,170 --> 00:24:09,310
+يعني عادة أول شي بيبدوا معاهم ب diet ممكن exercise
+
+302
+00:24:09,310 --> 00:24:13,570
+تخريف وزن فترة لاجوا و الله انه لأ في شفاية ده و
+
+303
+00:24:13,570 --> 00:24:16,730
+لسه ال glucose مرتفع بيبدوا معاهم ب ال medformin
+
+304
+00:24:16,730 --> 00:24:21,830
+او ال medformin زي ما بتعرفيه بيعمل على تقليل ال
+
+305
+00:24:21,830 --> 00:24:28,600
+release of glucose from the liverالمشكلة عند مرضى
+
+306
+00:24:28,600 --> 00:24:32,200
+السكر أنه مع الارتفاع في الجلوكوز الموجود لأن
+
+307
+00:24:32,200 --> 00:24:41,580
+الكبد أيضًا بيزيد اللي هو بينتج الجلوكوز الآن الـ
+
+308
+00:24:41,580 --> 00:24:44,300
+general practitioner was wondering whether his man
+
+309
+00:24:44,300 --> 00:24:49,520
+needed to start on insulin يعني مع الـ poor
+
+310
+00:24:49,520 --> 00:24:56,030
+control للجلوكوز الموجودففكر إنه يبدأله بإنسلين
+
+311
+00:24:56,030 --> 00:25:01,690
+عدة أعضاء عائلات قريبة أيضًا كانوا مرتبطين بشكل
+
+312
+00:25:01,690 --> 00:25:04,970
+عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام
+
+313
+00:25:04,970 --> 00:25:10,210
+بشكل عام بشكل عام بشكل عام بشكل عام بشكل
+
+314
+00:25:10,210 --> 00:25:10,630
+عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام
+
+315
+00:25:10,630 --> 00:25:10,670
+بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل
+
+316
+00:25:10,670 --> 00:25:13,640
+عام بشكل عام بشكل عام بشكل عام بشكل عامالـ Body
+
+317
+00:25:13,640 --> 00:25:18,460
+Mass Index مش عالية يعني مش obese لأن هو 26 يعني
+
+318
+00:25:18,460 --> 00:25:24,700
+بيعتبر لأنه الطبيعي لغاية 24.9 تمام فهو 1.26 يعني
+
+319
+00:25:24,700 --> 00:25:31,320
+فعليا وزنه مش كتير فوق الوزن الطبيعي وضغطه طبيعي
+
+320
+00:25:31,320 --> 00:25:37,060
+وفي عنده family يعني history بأنه ال diabetes تمام
+
+321
+00:25:37,060 --> 00:25:41,580
+يعني المؤشرات بتدلش على أنه عنده بتاعته diabetes
+
+322
+00:25:41,580 --> 00:25:46,400
+follitisهذا اللي هو الشخص In view of the strong
+
+323
+00:25:46,400 --> 00:25:49,560
+family history of diabetes أكتر that he did not
+
+324
+00:25:49,560 --> 00:25:52,140
+fit the typical phenotype of type 2 diabetes
+
+325
+00:25:52,140 --> 00:25:56,000
+mellitus لأنه relatively young، not obese nor
+
+326
+00:25:56,000 --> 00:25:59,540
+motensive possibility of maturity against diabetes
+
+327
+00:25:59,540 --> 00:26:04,900
+of the young was raised وهذه فعليًا مشكلة العديد
+
+328
+00:26:04,900 --> 00:26:10,360
+من الأشخاص اللي فعليًا عندهم الموديبيتم تشكيزهم
+
+329
+00:26:10,360 --> 00:26:16,300
+خطأ على أنه عندهم type 2 diabetes folate طبعا اللي
+
+330
+00:26:16,300 --> 00:26:19,860
+.. اللي زي ما انتوا شايفين انه العلاج بيختلف يعني
+
+331
+00:26:19,860 --> 00:26:22,620
+هى هدا كان شخصيا على انه type 2 diabetes folate
+
+332
+00:26:22,620 --> 00:26:26,560
+بياخد علاج لكن فعليا فيه poor control لglucose
+
+333
+00:26:26,560 --> 00:26:30,460
+فدعم التشكيز السليم أكيد يعني بيصيح فينا better
+
+334
+00:26:30,460 --> 00:26:38,020
+management ل ال patientالان الموضي ممكن عن طريق
+
+335
+00:26:38,020 --> 00:26:42,940
+الـ Molecular Analysis Genotyping revealed a
+
+336
+00:26:42,940 --> 00:26:50,460
+mutation in the HNF1 Alpha-Gene وهذا الجين له
+
+337
+00:26:50,460 --> 00:26:54,500
+علاقة بالـ Beta-Cells و الـ Release of Insulin
+
+338
+00:26:54,500 --> 00:26:59,340
+والميوتاشيون في هذا الجين بيؤدي إلى Decrease
+
+339
+00:26:59,340 --> 00:27:05,330
+Release of Insulin from Beta-Cellsهذا هو المشكلة
+
+340
+00:27:05,330 --> 00:27:14,750
+عند هذا الملعب متفورمين كان موقفًا، والآن نريد شيء
+
+341
+00:27:14,750 --> 00:27:20,590
+فقط يزيد من إطلاق الإنسلين، هناك أدوية لدينا، وهذه
+
+342
+00:27:20,590 --> 00:27:24,990
+مرحلة بعد متفورمين، تعمل استيميلاش للبنكرياس ويزيد
+
+343
+00:27:24,990 --> 00:27:32,490
+من إطلاق الإنسلين، هذا ما كان محتاجه، وهو العلاج
+
+344
+00:27:33,140 --> 00:27:37,760
+يبيعطوه له دوز of glucoside تمام؟ هو عبارة عن
+
+345
+00:27:37,760 --> 00:27:43,300
+سالفونيوليا هذه مجموعة من الأدوية هذه الأدوية
+
+346
+00:27:43,300 --> 00:27:49,720
+بتزيد من اللي هو ال insulin secretion الكاسك تالتة
+
+347
+00:27:49,720 --> 00:27:53,920
+الدليمان was visited by his son and was found to
+
+348
+00:27:53,920 --> 00:28:00,100
+be semi-conscious جراجر كوير و ابنه زار و لجأ انه
+
+349
+00:28:00,100 --> 00:28:04,440
+مش مصح صحي زي كأنه مغيبينالقابلين كانوا يلاحظوا
+
+350
+00:28:04,440 --> 00:28:07,640
+عنه حوالي 10 أيام قبل ذلك. أخر مرة شفوه قبل عشر
+
+351
+00:28:07,640 --> 00:28:11,300
+أيام جلانه، when he had seemed well، كان فيش فيه
+
+352
+00:28:11,300 --> 00:28:13,600
+مشكلة ومباين طبيعي، he was admitted to hospital.
+
+353
+00:28:14,320 --> 00:28:17,860
+On examination, he appeared extremely dehydrated.
+
+354
+00:28:18,560 --> 00:28:21,760
+كان برضه فيه أندفع كبير للسوائل. Results of
+
+355
+00:28:21,760 --> 00:28:26,970
+biochemical investigations were as followsاليوريا
+
+356
+00:28:26,970 --> 00:28:33,510
+عندنا 38 ملي مول او 1006 ملي جرام بردساليتا اللي
+
+357
+00:28:33,510 --> 00:28:36,170
+في عندنا ارتفاع الكلية التانية الواحد و نصف برضه
+
+358
+00:28:36,170 --> 00:28:38,590
+في عندنا ارتفاع اللي في ارتفاع في اليوريا و
+
+359
+00:28:38,590 --> 00:28:41,810
+بالكلية التانية و هذا ما زال فيه dehydration زي ما
+
+360
+00:28:41,810 --> 00:28:44,770
+شوفنا بالحالة السابقة اللي ما زال فيه dehydration
+
+361
+00:28:44,770 --> 00:28:47,990
+اللي في عندنا اللي هو pre-renal ممكن أزوتياميا
+
+362
+00:28:47,990 --> 00:28:51,650
+ممكن هذه تكون اللي هو سبب الارتفاع في اليوريا و
+
+363
+00:28:51,650 --> 00:28:55,720
+الكلية التانيةعندنا الصوديوم في ارتفاع في الصوديوم
+
+364
+00:28:55,720 --> 00:29:02,340
+البوتاسيوم الطبيعي اللي برضه في انخفاض في اللي هو
+
+365
+00:29:02,340 --> 00:29:09,280
+الـ CO2 18% الجلوكوز برضه مرتفع بشكل كبير 1098
+
+366
+00:29:09,280 --> 00:29:13,820
+ميلي جرام بالديسليتر والـ Osmolality برضه عندنا
+
+367
+00:29:13,820 --> 00:29:17,060
+مرتفعة طبعا الناس اللي
+
+368
+00:29:23,780 --> 00:29:29,000
+مصابين بالتدو دا باسم Litas من ال complications
+
+369
+00:29:29,000 --> 00:29:32,580
+اللي ممكن تكون عندهم ال acute انه بيصير في عندهم
+
+370
+00:29:32,580 --> 00:29:38,940
+ال hyperosmolar non-ketonic اللي بيصير في عندهم
+
+371
+00:29:38,940 --> 00:29:45,660
+ارتفاع في ال osmolality تمام، لكن بيكونش فيه
+
+372
+00:29:45,660 --> 00:29:50,660
+ارتفاع في ال ketone bodies اه، يبقى هذا اللي هو
+
+373
+00:29:50,660 --> 00:29:58,020
+اللي بيفرقعشان هيك اللي هو الـ Ketones مهم انه
+
+374
+00:29:58,020 --> 00:30:02,780
+يعمل اللي هو اللي تفرقها يبقى فيه عنا سيفير
+
+375
+00:30:02,780 --> 00:30:07,360
+hyperglycemia وهذه هي اللي قدت الى ارتفاع الـ
+
+376
+00:30:07,360 --> 00:30:10,540
+osmolality لأن اللي قولنا اللي بيكون osmotically
+
+377
+00:30:10,540 --> 00:30:14,520
+active hyperglycemia has driven on osmotic
+
+378
+00:30:14,520 --> 00:30:20,420
+diuresis برضه نفس الفكرةوهي تسبب في اختلاف افلود
+
+379
+00:30:20,420 --> 00:30:23,040
+اكتسرا واختلاف افلود اكتسرا واختلاف افلود اكتسرا
+
+380
+00:30:23,040 --> 00:30:24,240
+واختلاف افلود اكتسرا واختلاف افلود اكتسرا واختلاف
+
+381
+00:30:24,240 --> 00:30:25,680
+افلود اكتسرا واختلاف افلود اكتسرا واختلاف افلود
+
+382
+00:30:25,680 --> 00:30:28,220
+اكتسرا واختلاف افلود اكتسرا واختلاف افلود اكتسرا
+
+383
+00:30:28,220 --> 00:30:33,400
+واختلاف افلود اكتسرا واختلاف افلود اكتسرا واختلاف
+
+384
+00:30:33,400 --> 00:30:39,460
+افلود اكتسرا واختلاف افلود اكتسرا واختلاف افلود
+
+385
+00:30:39,460 --> 00:30:45,390
+اكتسرا واختلاف افإنه بيصير فيه hyperlipidemia لكن
+
+386
+00:30:45,390 --> 00:30:48,950
+قلنا الـ vomiting هو كان سبب إنه صار فيه فقد له
+
+387
+00:30:48,950 --> 00:30:53,970
+اللي هو الـ Sodium Total CO2 is slightly reduced
+
+388
+00:30:53,970 --> 00:30:58,570
+due to the impaired renal function but it's not as
+
+389
+00:30:58,570 --> 00:31:00,150
+low as what we expected in the case of
+
+390
+00:31:00,150 --> 00:31:03,270
+ketoacidosis في الـ ketoacidosis اللي شوفنا كان
+
+391
+00:31:03,270 --> 00:31:06,090
+عندنا الـ CO2 ال concentration أقل بهيك بكتير،
+
+392
+00:31:06,090 --> 00:31:11,850
+بصبح؟ with result as abnormal as thisالشخص كان
+
+393
+00:31:11,850 --> 00:31:14,630
+مميزاً بالفعل ولكن في النهاية كان قادر على إعطاء
+
+394
+00:31:14,630 --> 00:31:19,770
+مثال يورين الذي أعطى تجارب خاطئة لكيتونات وما كانش
+
+395
+00:31:19,770 --> 00:31:23,450
+في عندهم كيتونات واحنا قلنا إن ال .. يعني ال
+
+396
+00:31:23,450 --> 00:31:30,030
+ketoacidosis عادة بتكون في مرضى ال type 1 تمام؟
+
+397
+00:31:30,030 --> 00:31:34,170
+لأن قلنا بيكون في عندنا absolute deficiency of
+
+398
+00:31:34,170 --> 00:31:39,370
+insulin وقلنا إن ال .. ال insulin اللي فيه عنده
+
+399
+00:31:39,370 --> 00:31:42,400
+negativeاللي هو effect على الـ release of
+
+400
+00:31:42,400 --> 00:31:47,040
+الجلوكاجون فالآن لما الإنسلين يكون مش موجود فهذا
+
+401
+00:31:47,040 --> 00:31:50,380
+بيزيد من اللي هو الجلوكاجون وبيزيد من الـ
+
+402
+00:31:50,380 --> 00:31:53,460
+gluconeogenesis و اللي هو الـ lipid oxidation و
+
+403
+00:31:53,460 --> 00:31:59,160
+بالتالي بيصير في أننا اللي هو الارتفاع في الـ
+
+404
+00:31:59,160 --> 00:32:02,780
+ketone bodies لكن في الtype 2 diabetes mellitus
+
+405
+00:32:02,780 --> 00:32:06,740
+هدول المرضى عندهم إنسلين، مظبوط؟ يعني لو في
+
+406
+00:32:06,740 --> 00:32:11,680
+deficiencyلكن الإنسولين موجود مش زي اللواء الـ
+
+407
+00:32:11,680 --> 00:32:16,060
+Type I عشان إيه نادرًا ماء يصير كيتو أكسيدوزيز في
+
+408
+00:32:16,060 --> 00:32:19,820
+اللواء المرضى اللواء الـ Type II إلا إذا كانت ..
+
+409
+00:32:19,820 --> 00:32:23,080
+احنا بنحكي على مراحل متأخرة وصار فيه عندي ديتر
+
+410
+00:32:23,080 --> 00:32:26,940
+إيريشن بشكل كبير لـ Beta cells وصار فيه انخفار
+
+411
+00:32:26,940 --> 00:32:33,060
+ممكن بشكل كبير للإنسولين تمام، بيبين هذا المريض هي
+
+412
+00:32:38,140 --> 00:32:40,780
+يبقى .. لأن مافيش أنه كيتون bodies وفي أنه ارتفاع
+
+413
+00:32:40,780 --> 00:32:44,380
+طبعا شكل كبير بالسُكَر This one occurs in patients
+
+414
+00:32:44,380 --> 00:32:49,040
+with type 2 diabetes mellitus وعادة المرضى الـ
+
+415
+00:32:49,040 --> 00:32:51,580
+type 2 diabetes mellitus يعني ممكن يصابوا بهذه
+
+416
+00:32:51,580 --> 00:32:57,940
+الحالة ك acute complication فيه اللي هو حالات ال
+
+417
+00:32:57,940 --> 00:33:02,760
+.. ال severe illness تمام؟ يعني إذا كان صار فيه
+
+418
+00:33:02,760 --> 00:33:08,600
+مرض زي ما انتوا عارفينهي الـ stress hormones وهي
+
+419
+00:33:08,600 --> 00:33:14,680
+بعض الهرمونات تعتبر hyperglycemic agents وبالتالي
+
+420
+00:33:14,680 --> 00:33:19,240
+ممكن ترفع مستوى السكر بشكل كبير تؤدي إلى الـ non
+
+421
+00:33:19,240 --> 00:33:23,860
+-ketotic hyperglycemia أو الـ hyperosmolar non
+
+422
+00:33:23,860 --> 00:33:24,300
+-ketotic
+
+423
+00:33:28,290 --> 00:33:31,930
+هؤلاء المريضين يحافظون على الإنسولين لتحفة
+
+424
+00:33:31,930 --> 00:33:37,510
+كيتوجينيس لكنه ليس كافيا لتحفة الـHyperglycemia
+
+425
+00:33:37,510 --> 00:33:41,350
+تمام؟ لأن وجود الإنسولين زي ما قلنا بيمنع اللي
+
+426
+00:33:41,350 --> 00:33:46,010
+يحصل في عنا اللي هو الـ Ketogenesis طيب الإعلاج
+
+427
+00:33:46,010 --> 00:33:50,270
+هدول المرضى بـ Placement of Fluid and Electrolyte
+
+428
+00:33:50,270 --> 00:33:56,140
+Loss و بإنسولين Infusion لتحفة الـ Glucoseيبعطوهم
+
+429
+00:33:56,140 --> 00:33:58,420
+انسولين عشان يلزموا الجلوكوز هدول عندهم
+
+430
+00:33:58,420 --> 00:34:03,860
+dehydration بيبعطوهم الوثوائل ليه اللي هو إرجاع ال
+
+431
+00:34:03,860 --> 00:34:08,420
+blood value إلى الطبيعي once the acute episode is
+
+432
+00:34:08,420 --> 00:34:13,100
+over انسولين is unlikely to be needed بس تخلص
+
+433
+00:34:13,100 --> 00:34:17,040
+المشكلة يعني ممكن نرجع المريض للعلاج السابق اللي
+
+434
+00:34:17,040 --> 00:34:21,320
+كان ياخده و بوقفه الانسولين زكاه ماكانش بياخد
+
+435
+00:34:21,320 --> 00:34:27,250
+انسولينطيب لما سأله المريض هاد يعني ماشيفي إيش
+
+436
+00:34:27,250 --> 00:34:32,270
+المشكلة he reported having experienced increasing
+
+437
+00:34:32,270 --> 00:34:35,530
+thirst and poliurea و هذه الفترة الصالة هي يعني
+
+438
+00:34:35,530 --> 00:34:39,110
+كمان in several weeks يبقى الظاهر كان عنده
+
+439
+00:34:39,110 --> 00:34:45,910
+الجلوكوز مرتفع و لأنه فيه urination و فيه thirst،
+
+440
+00:34:45,910 --> 00:34:51,870
+تمام؟ فهذا بعد ما يشرب ميه، إيش كان يشرب؟ كان يشرب
+
+441
+00:34:51,870 --> 00:34:58,850
+لمناطقفيها طبعا نسبة سكر كبير طبعا فهو بياخد ميه و
+
+442
+00:34:58,850 --> 00:35:03,670
+بياخد ايش بزيد الطين بلا بياخد كمان سكر اللي هو
+
+443
+00:35:03,670 --> 00:35:08,250
+أصلا عنده مرتفع لغاية ما انتهى العمر عنده بارتفاع
+
+444
+00:35:08,250 --> 00:35:11,910
+بشكل كبير و ب ال dehydration و ارتفاع بالأزمة
+
+445
+00:35:11,910 --> 00:35:15,570
+الليلية زي ما شوفنا طيب الحالة الأخيرة
+
+446
+00:35:26,540 --> 00:35:30,980
+A 45-year-old woman who was unable to feed, wash
+
+447
+00:35:30,980 --> 00:35:34,840
+or dress herself because of severe multiple
+
+448
+00:35:34,840 --> 00:35:39,020
+sclerosis المعنى بيجي في عندها multiple sclerosis
+
+449
+00:35:39,020 --> 00:35:42,420
+اللي هو اتصلوا بالمتعدد فيه مشكلة عند دول المعروف
+
+450
+00:35:42,420 --> 00:35:46,320
+بيكون طبعا بيه اللي هو المياه اللي ينشيه وبالتالي
+
+451
+00:35:46,320 --> 00:35:54,060
+في مشكلة عندهم بيه ال .. طبعا ال nerve signalواللي
+
+452
+00:35:54,060 --> 00:35:59,440
+هو التوصيل اللي هو إشارات العصبية وهذا طبعا يعني
+
+453
+00:35:59,440 --> 00:36:04,040
+فيه إله complications عديدة يعني بتأثر على كل
+
+454
+00:36:04,040 --> 00:36:11,740
+نواحي الحياة عندهم ماشي أكل حركة على كل إشي طيب و
+
+455
+00:36:11,740 --> 00:36:14,780
+هذه المريضة اللي عمرها 45 سنة عندها multiple
+
+456
+00:36:14,780 --> 00:36:20,610
+sclerosisوكان في CV multiple sclerosis وبالتالي هي
+
+457
+00:36:20,610 --> 00:36:24,650
+لا هي جادة تاكل ولا جادة تلبس ولا جادة تتحمم ولا
+
+458
+00:36:24,650 --> 00:36:29,470
+جادة تعمل أي إشي وكانت موجودة فعليا في nursing
+
+459
+00:36:29,470 --> 00:36:32,730
+home يعني في دار للريعاية وهم اللي كانوا باهتموا
+
+460
+00:36:32,730 --> 00:36:39,750
+فيها about six hours after a visit by relatives it
+
+461
+00:36:39,750 --> 00:36:44,850
+was found that she could not be roused يبقى ضرورة
+
+462
+00:36:44,850 --> 00:36:48,600
+أقربهاكان في زيارة الأقل بقى و بعد ست ساعات من
+
+463
+00:36:48,600 --> 00:36:54,640
+انتهاء الزيارة اجلغوها هي كانت مش مصحصة حقيقية بعد
+
+464
+00:36:54,640 --> 00:36:58,920
+ست
+
+465
+00:36:58,920 --> 00:37:04,160
+ساعات مرادروا المكان on admission to a hospital
+
+466
+00:37:04,160 --> 00:37:08,900
+she was found to be extremely hypoglycemic و هذا
+
+467
+00:37:08,900 --> 00:37:13,080
+السبب ان هي زي ايش في نقص شديد بالسكر و glucose
+
+468
+00:37:13,080 --> 00:37:16,870
+اربعة و تلاتين milligram per deciliterتعرفين أقل
+
+469
+00:37:16,870 --> 00:37:20,970
+من الخمسين اللي هو الشخص يدخل في hypoglycemia
+
+470
+00:37:20,970 --> 00:37:23,570
+وطبعا أه يعني هذه تعتبر life threatening condition
+
+471
+00:37:23,570 --> 00:37:26,950
+يعني ممكن يدخل في كومة و ممكن هذه تؤدي إلى الوفاء
+
+472
+00:37:26,950 --> 00:37:34,070
+إذا ما صارش فيه يعني علاج بشكل عاجل طيب required
+
+473
+00:37:34,070 --> 00:37:36,610
+repeated intravenous infusion of glucose مزال في
+
+474
+00:37:36,610 --> 00:37:41,210
+hypoglycemia بغض النظر عن السبب المفروض أطول ينعطى
+
+475
+00:37:41,210 --> 00:37:42,590
+ال patient glucose
+
+476
+00:37:45,510 --> 00:37:50,330
+2 من 2 بلازمة بلوكوز over the next 12 to 24 hours
+
+477
+00:37:50,330 --> 00:37:55,170
+a sample of blood taken on admission was restored
+
+478
+00:37:55,170 --> 00:37:58,250
+and subsequently analyzed for insulin and C
+
+479
+00:37:58,250 --> 00:38:02,770
+-peptide بياخدوا عينة و تحسوا باليعني الدم ال
+
+480
+00:38:02,770 --> 00:38:07,150
+result يعني بياخدوا عينة يعني ممكن لاحقا يشكوا أنه
+
+481
+00:38:07,150 --> 00:38:10,670
+في إشي معين في الدم وبالتالي العينة بتكون موجودة و
+
+482
+00:38:10,670 --> 00:38:15,720
+ممكن يفحصوهاتمام يبقى من الفحصات اللي عملوها عملوا
+
+483
+00:38:15,720 --> 00:38:17,680
+انسولين وعملوا C-peptide result were
+
+484
+00:38:17,680 --> 00:38:22,440
+inappropriately raised كان في عندنا ارتفاع في
+
+485
+00:38:22,440 --> 00:38:28,660
+الانسولين وفي ال C-peptide وهذا اللي هو السبب ان
+
+486
+00:38:28,660 --> 00:38:33,240
+في عندنا hypoglycemia تمام الارتفاع بالانسولين
+
+487
+00:38:33,240 --> 00:38:39,110
+تمام اكيد ممكن يقدي الىاللي هو hypoglycemia وهذا
+
+488
+00:38:39,110 --> 00:38:44,850
+اللي بيصير يعني في عندنا يعني بعد مرضى السكر مثلا
+
+489
+00:38:44,850 --> 00:38:49,910
+اللي بياخدوا insulin تمام ممكن يصير في عندهم
+
+490
+00:38:49,910 --> 00:38:52,870
+hypoglycemia طبعا السبب ممكن يكون أنه أخد جرعة
+
+491
+00:38:52,870 --> 00:38:58,870
+زايدة أخد الجرعة ماأكلش أخد الجرعة ماأكلش الفطور
+
+492
+00:38:58,870 --> 00:39:01,610
+اللي عادة بياكله مثلا اللي في كمية معينة من ال
+
+493
+00:39:01,610 --> 00:39:05,590
+carbohydrates ممكن يكون أخد الجرعة وبدأ المجهود
+
+494
+00:39:05,590 --> 00:39:10,790
+أكبرتمام؟ يعني إيه؟ صار فيه مجهود أكبر عادة بتمشي
+
+495
+00:39:10,790 --> 00:39:14,110
+يعني بذله؟ هذه ممكن كلها تؤدي إلى اللي هو
+
+496
+00:39:14,110 --> 00:39:20,190
+hypoglycemia طيب over the next few days repeated
+
+497
+00:39:20,190 --> 00:39:24,650
+overnight fasts failed to induce further
+
+498
+00:39:24,650 --> 00:39:26,090
+hypoglycemia
+
+499
+00:39:27,790 --> 00:39:32,890
+يبقى يعني لأنه هان بشكه ما زال في عنا زيادة في ال
+
+500
+00:39:32,890 --> 00:39:35,810
+insulin و في عنا زيادة في ال C-peptide يبقى علاته
+
+501
+00:39:35,810 --> 00:39:41,330
+ال insulin إيش داخلي مظبوط ما زال في C-peptide
+
+502
+00:39:41,330 --> 00:39:46,730
+يبقى ال insulin إيش داخلي و هي بتاخدش insulin يعني
+
+503
+00:39:46,730 --> 00:39:51,380
+يبقى بشكه أنه ممكن يكون في إيش Encelanomaتمام؟ في
+
+504
+00:39:51,380 --> 00:39:53,700
+عندنا ممكن cancer في ال beta cells وفي إنتاج
+
+505
+00:39:53,700 --> 00:39:59,300
+بكميات كبيرة للإنسلين الأن هدول يعني عشان يشوفوا
+
+506
+00:39:59,300 --> 00:40:05,420
+أنه فعلا أنه زيادة في ال insulin بسبب ال insulin
+
+507
+00:40:05,420 --> 00:40:10,140
+load ما بيعمل overnight لوا fast والمفروض أن يحصل
+
+508
+00:40:10,140 --> 00:40:14,320
+فيه hypoglycemia لو فعلا في لوا insulin load
+
+509
+00:40:14,320 --> 00:40:20,180
+eventually after a prolonged fastفي أربع أيام
+
+510
+00:40:20,180 --> 00:40:27,360
+الجلوكوز اتفق إلى 45 يعني في اليوم الرابع نزل
+
+511
+00:40:27,360 --> 00:40:33,520
+لجلوكوز ل 45 في وقت ما انسولين وC-Peptide كانوا
+
+512
+00:40:33,520 --> 00:40:39,860
+غير ملاحظين يعني ماكنش في عندنا الارتفاع في
+
+513
+00:40:39,860 --> 00:40:47,400
+انسولين زي المرة الأولى نتيجة الدراسة
+
+514
+00:40:51,830 --> 00:40:54,530
+هيبوغلايسيمية ارتفاع في الإنسلين وارتفاع في الـ C
+
+515
+00:40:54,530 --> 00:40:59,190
+-Peptide يدوم كلهم يشيروا إلى إنه في عنده زيادة في
+
+516
+00:40:59,190 --> 00:41:04,630
+إفراز الإنسلين وبيتاليه كل كيلون انسلين طيب هل هو
+
+517
+00:41:04,630 --> 00:41:07,530
+ذرع تثبت صعوبة تدفعك إلى أكتر حلقة من
+
+518
+00:41:07,530 --> 00:41:10,910
+الهيبوغلايسيمية؟ هذا ما قلنا إن أكتر الأشخاص مع
+
+519
+00:41:10,910 --> 00:41:15,050
+انسلنومة سيكونوا هيبوغلايسيميك على أحد أو أكتر
+
+520
+00:41:15,050 --> 00:41:21,290
+حلقات بعد ثلاث فاصلات عامةلو صار فيه صوم overnight
+
+521
+00:41:21,290 --> 00:41:24,550
+فاصلة لمدة تلت أيام إلا يصير في عندهم hypoglycemia
+
+522
+00:41:24,550 --> 00:41:28,990
+مرة تانية لكن هذا المريضة صار في overnight فاصلة
+
+523
+00:41:28,990 --> 00:41:32,590
+لمدة تلت أيام لكن ماصارش فيه hypoglycemia و باليوم
+
+524
+00:41:32,590 --> 00:41:39,750
+الرابع صار فيه انخفاض و نزل لـ45 و even prolonged
+
+525
+00:41:39,750 --> 00:41:43,550
+fast failed to induce true hypoglycemia and at
+
+526
+00:41:43,550 --> 00:41:47,510
+that time insulin level was appropriately lowلم
+
+527
+00:41:47,510 --> 00:41:51,210
+يكنش فيه إرتفاع Review of her history revealed no
+
+528
+00:41:51,210 --> 00:41:56,490
+suggestion of previous hypoglycemic episodes تمام؟
+
+529
+00:41:56,490 --> 00:42:01,410
+كمان ما قمرش يعني صار عندها hypoglycemia سابقا
+
+530
+00:42:01,410 --> 00:42:04,790
+Clinical staff were accordingly forced to
+
+531
+00:42:04,790 --> 00:42:08,630
+reconsider the initial diagnosis يعني بعد هذه
+
+532
+00:42:08,630 --> 00:42:13,630
+الفحصات اللي قملوها يرجعوا جالوا باحتمال عندها مرة
+
+533
+00:42:13,630 --> 00:42:14,710
+تانية اللي هو Enceloma
+
+534
+00:42:23,340 --> 00:42:28,380
+العينة اللي احتفظوا فيها رجوا بعتوا هشوفوا and was
+
+535
+00:42:28,380 --> 00:42:30,660
+found to contain high concentrations of the oral
+
+536
+00:42:30,660 --> 00:42:37,340
+hypoglycemic drugs Chloropropamide و Eglipin
+
+537
+00:42:37,340 --> 00:42:43,720
+Clamide وهده ال drugs هم عبارة عن sulfonylurea
+
+538
+00:42:45,250 --> 00:42:50,670
+الأدوية التي قمنا بتعملها تزيد من إفراز
+
+539
+00:42:50,670 --> 00:42:54,850
+الإنسفلينة، مجبور؟ مجبور أن الpatient اللي كان فيه
+
+540
+00:42:54,850 --> 00:42:58,230
+اندولبودي يعطوه اللي هو الـ Sulfonylurea عشان
+
+541
+00:42:58,230 --> 00:43:01,850
+يزيدوا فقط إيش من إفراز اللي هو الإنسفلينة اللي
+
+542
+00:43:01,850 --> 00:43:06,390
+عنده طيب، these drugs Sulfonylurea which act by
+
+543
+00:43:06,390 --> 00:43:08,890
+enhancing pancreatic insulin secretion in response
+
+544
+00:43:08,890 --> 00:43:16,640
+to glucoseهدوم النوعين have long half-lives، الـ
+
+545
+00:43:16,640 --> 00:43:21,000
+half-life بتاعتهم أيش كمان؟ طويلة، making
+
+546
+00:43:21,000 --> 00:43:25,440
+hypoglycemia an occasional problem even when used
+
+547
+00:43:25,440 --> 00:43:28,580
+therapeutically in patients with diabetes
+
+548
+00:43:33,600 --> 00:43:36,000
+طيب، ماذا يجب أن تحصل على هذه الأدوية؟ ممكن أن
+
+549
+00:43:36,000 --> 00:43:39,160
+تحصل على أو تأخذ هذه الأدوية؟ لأننا قلنا لا جادرة
+
+550
+00:43:39,160 --> 00:43:43,120
+تأكل ولا جادرة تشرب ولا جادرة تعمل إشي طب كيف هذه
+
+551
+00:43:43,120 --> 00:43:49,020
+الأدوية ما زال الممرضين ما أعطوهاش؟ كيف وصلت ودخلت
+
+552
+00:43:49,020 --> 00:43:57,920
+جسمها؟ يبقى صار إيش كأنه محاولة قتل طيب، it was
+
+553
+00:43:57,920 --> 00:44:00,860
+likely that a relative distressed by hair
+
+554
+00:44:00,860 --> 00:44:05,900
+conditionمن الناس الأقارب اللي جذبوها حزنوا عليها
+
+555
+00:44:05,900 --> 00:44:14,060
+شفوها بالحالة هذه فظاهر واحد إيش بده يعني ينهي
+
+556
+00:44:14,060 --> 00:44:18,700
+حياته طيب ال police were informed that it was felt
+
+557
+00:44:18,700 --> 00:44:22,040
+that there was insufficient evidence to proceed
+
+558
+00:44:22,040 --> 00:44:27,400
+الفرق يعني صار في إغلاق القضية لعدم كفاية الأدلة
+
+559
+00:44:27,400 --> 00:44:31,720
+زي ما بيحكوا يعطيكوا ألف عافية
+
diff --git a/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/pTZfQgG5v8w_raw.json b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/pTZfQgG5v8w_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..990c01764251f779e7d44d2c88409d88ac211943
--- /dev/null
+++ b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/pTZfQgG5v8w_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 2636, "start": 2.16, "end": 26.36, "text": "Ten year old male presented to the emergency department with recent history of polydipsia يبقى طفل عمره عشر سنين ودخل اللي هو الاستقبال في المستشفى وعنده اللي هو عطش fast polydipsia", "tokens": [51, 268, 1064, 1331, 7133, 8212, 281, 264, 7473, 5882, 365, 5162, 2503, 295, 6754, 67, 2600, 654, 7251, 3555, 4587, 7578, 23032, 5172, 1211, 6225, 29973, 3224, 6225, 46309, 8608, 1863, 9957, 4032, 3215, 9778, 1211, 13672, 1829, 31439, 42963, 14851, 4587, 3555, 6027, 8978, 9673, 14851, 8592, 5172, 7578, 4032, 3615, 41260, 3224, 13672, 1829, 31439, 6225, 9566, 8592, 2370, 6754, 67, 2600, 654], "avg_logprob": -0.19589552639135674, "compression_ratio": 1.3519553072625698, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 2.16, "end": 2.76, "word": "Ten", "probability": 0.533447265625}, {"start": 2.76, "end": 2.96, "word": " year", "probability": 0.62109375}, {"start": 2.96, "end": 3.36, "word": " old", 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1093.36, "end": 1121.82, "text": "المفروض ايش بيعمل؟ اللي هو بزيد من إفراز الـ antihydrated hormone عشان يصبح عنده more absorption للميّه وبيعطي إحساس بالعطش يبقى هان في عندنا اللي هو thirst هان اللي في عندنا يوريميا اللي هو ارتفاع في مستوى اليوريا والـhypovolemia اللي صار", "tokens": [45340, 5172, 32887, 11242, 1975, 1829, 8592, 4724, 1829, 25957, 1211, 22807, 13672, 1829, 31439, 4724, 11622, 25708, 9154, 11933, 5172, 2288, 31377, 2423, 39184, 2511, 4247, 6655, 5468, 24211, 6225, 8592, 7649, 7251, 9381, 49628, 43242, 3224, 544, 27557, 5296, 19528, 1829, 11703, 3224, 4032, 21292, 3615, 9566, 1829, 11933, 5016, 3794, 32277, 20666, 3615, 9566, 8592, 7251, 3555, 4587, 7578, 8032, 7649, 8978, 43242, 8315, 13672, 1829, 31439, 34846, 8032, 7649, 13672, 1829, 8978, 43242, 8315, 7251, 13063, 32640, 25528, 13672, 1829, 31439, 1975, 43500, 5172, 45761, 8978, 3714, 14851, 2407, 7578, 45595, 13063, 25528, 4032, 6027, 39184, 3495, 2259, 3080, 10386, 654, 13672, 1829, 20328, 9640], "avg_logprob": 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0.855712890625}, {"start": 1309.7, "end": 1310.26, "word": " بتفت", "probability": 0.3987223307291667}, {"start": 1310.26, "end": 1310.8, "word": " عندى", "probability": 0.541015625}, {"start": 1310.8, "end": 1310.96, "word": " ال", "probability": 0.97705078125}, {"start": 1310.96, "end": 1311.18, "word": " hydrogen", "probability": 0.96240234375}, {"start": 1311.18, "end": 1311.46, "word": " ions", "probability": 0.90234375}, {"start": 1311.46, "end": 1313.02, "word": " طيب", "probability": 0.8751627604166666}, {"start": 1313.02, "end": 1313.38, "word": " هنا", "probability": 0.267578125}, {"start": 1313.38, "end": 1314.0, "word": " عندنا", "probability": 0.973388671875}, {"start": 1314.0, "end": 1315.18, "word": " ال", "probability": 0.97021484375}, {"start": 1315.18, "end": 1315.86, "word": " H2O", "probability": 0.9773763020833334}], "temperature": 1.0}, {"id": 56, "seek": 133109, "start": 1316.75, "end": 1331.09, "text": "مع الـ CO2 قالوا بيعطينا H2CO3 هذي بيصير لها الassociation لـ HCO3 و Hydrogen اللي هو I", "tokens": [2304, 3615, 2423, 39184, 3002, 17, 50239, 14407, 4724, 1829, 3615, 9566, 1829, 8315, 389, 17, 12322, 18, 8032, 8848, 1829, 4724, 1829, 9381, 13546, 5296, 11296, 2423, 49146, 399, 5296, 39184, 389, 12322, 18, 4032, 24231, 7747, 13672, 1829, 31439, 286], "avg_logprob": -0.47420057723688525, "compression_ratio": 1.135135135135135, "no_speech_prob": 8.881092071533203e-06, "words": [{"start": 1316.75, "end": 1317.35, "word": "مع", "probability": 0.5191650390625}, {"start": 1317.35, "end": 1318.13, "word": " الـ", "probability": 0.582763671875}, {"start": 1318.13, "end": 1319.03, "word": " CO2", "probability": 0.750244140625}, {"start": 1319.03, "end": 1320.35, "word": " قالوا", "probability": 0.610107421875}, {"start": 1320.35, "end": 1321.05, "word": " بيعطينا", "probability": 0.833984375}, {"start": 1321.05, "end": 1323.41, "word": " H2CO3", "probability": 0.8955078125}, {"start": 1323.41, "end": 1324.19, "word": " هذي", "probability": 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الـ hydrogen ions يحدث فيه hyperventilation ماهو hyperventilation؟ يعني معدل التنفس بيزيد تمام؟ لما معدل التنفس بيزيد، ماذا يحدث فينا؟ more exhalation of CO2 يحدث فينا فقط لكميات أكبر من الـCO2، إذا ماهو حدث لـCO2؟", "tokens": [4117, 2304, 3555, 1863, 3794, 1829, 8592, 1863, 3714, 1829, 41361, 1829, 11622, 2304, 5296, 15042, 7251, 24401, 12984, 8978, 8315, 1975, 43500, 5172, 45761, 8978, 2423, 39184, 12697, 27362, 7251, 24401, 12984, 8978, 3224, 9848, 2475, 16067, 19446, 3224, 2407, 9848, 2475, 16067, 22807, 37495, 22653, 20449, 3215, 1211, 16712, 1863, 36178, 4724, 1829, 11622, 25708, 46811, 10943, 22807, 5296, 15042, 20449, 3215, 1211, 16712, 1863, 36178, 4724, 1829, 11622, 25708, 12399, 3714, 45636, 995, 7251, 24401, 12984, 8978, 8315, 22807, 544, 454, 4947, 399, 295, 3002, 17, 7251, 24401, 12984, 8978, 8315, 6156, 47432, 5296, 24793, 1829, 9307, 5551, 4117, 26890, 9154, 2423, 39184, 12322, 17, 12399, 11933, 15730, 19446, 3224, 2407, 11331, 3215, 12984, 5296, 39184, 12322, 17, 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"end": 1682.24, "text": "يبيعطوه له دوز of glucoside تمام؟ هو عبارة عن سالفونيوليا هذه مجموعة من الأدوية هذه الأدوية بتزيد من اللي هو ال insulin secretion الكاسك تالتة الدليمان was visited by his son and was found to be semi-conscious جراجر كوير و ابنه زار و لجأ انه مش مصح صحي زي كأنه مغيبين", "tokens": [1829, 21292, 3615, 9566, 2407, 3224, 46740, 11778, 2407, 11622, 295, 1563, 1311, 329, 482, 46811, 10943, 22807, 31439, 6225, 3555, 9640, 3660, 18871, 8608, 6027, 5172, 11536, 1829, 12610, 25528, 29538, 3714, 7435, 2304, 2407, 27884, 9154, 16247, 3215, 2407, 10632, 29538, 16247, 3215, 2407, 10632, 39894, 11622, 25708, 9154, 13672, 1829, 31439, 2423, 21587, 4054, 313, 33251, 32277, 4117, 6055, 6027, 2655, 3660, 2423, 3215, 20292, 2304, 7649, 390, 11220, 538, 702, 1872, 293, 390, 1352, 281, 312, 12909, 12, 19877, 10874, 2288, 26108, 2288, 9122, 45865, 2288, 4032, 48127, 1863, 3224, 30767, 9640, 4032, 5296, 7435, 10721, 16472, 3224, 37893, 3714, 9381, 5016, 20328, 5016, 1829, 30767, 1829, 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On examination, he appeared extremely dehydrated. كان برضه فيه أندفع كبير للسوائل. 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فظاهر واحد إيش بده يعني ينهي حياته طيب ال police were informed that it was felt that there was insufficient evidence to proceed الفرق يعني صار في إغلاق القضية لعدم كفاية الأدلة زي ما بيحكوا يعطيكوا ألف عافية", "tokens": [27842, 2423, 8315, 3794, 16247, 4587, 9640, 3555, 13672, 1829, 10874, 8848, 3555, 2407, 11296, 11331, 11622, 1863, 14407, 25894, 11296, 13412, 5172, 2407, 11296, 20666, 5016, 6027, 3660, 29538, 6156, 19913, 40294, 2288, 36764, 24401, 11933, 1829, 8592, 47525, 3224, 37495, 22653, 7251, 1863, 3224, 1829, 11331, 1829, 9307, 3224, 23032, 1829, 3555, 2423, 3804, 645, 11740, 300, 309, 390, 2762, 300, 456, 390, 41709, 4467, 281, 8991, 27188, 2288, 4587, 37495, 22653, 20328, 9640, 8978, 11933, 17082, 15040, 4587, 25062, 11242, 10632, 5296, 22488, 2304, 9122, 5172, 995, 10632, 16247, 3215, 37977, 30767, 1829, 19446, 4724, 1829, 5016, 4117, 14407, 37495, 9566, 1829, 4117, 14407, 5551, 46538, 6225, 31845, 10632], "avg_logprob": -0.2645187968701388, "compression_ratio": 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\ No newline at end of file
diff --git a/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/pTZfQgG5v8w_raw.srt b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/pTZfQgG5v8w_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..10d53abe6563cff0aaab5e06e15b00af0c37885c
--- /dev/null
+++ b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/pTZfQgG5v8w_raw.srt
@@ -0,0 +1,2244 @@
+1
+00:00:02,160 --> 00:00:06,640
+Ten year old male presented to the emergency
+
+2
+00:00:06,640 --> 00:00:12,740
+department with recent history of polydipsia يبقى
+
+3
+00:00:12,740 --> 00:00:19,500
+طفل عمره عشر سنين ودخل اللي هو الاستقبال في
+
+4
+00:00:19,500 --> 00:00:28,200
+المستشفى وعنده اللي هو عطش fast polydipsiaبوليوريا
+
+5
+00:00:28,200 --> 00:00:36,820
+وفيه يعني frequent urination و vomiting on
+
+6
+00:00:36,820 --> 00:00:41,920
+admission blood specimens were collected for
+
+7
+00:00:41,920 --> 00:00:44,480
+routine chemistries and gases with the following
+
+8
+00:00:44,480 --> 00:00:52,020
+results بيأخذوا منه عينا وفحصوا ال electrolytes في
+
+9
+00:00:52,020 --> 00:00:55,730
+السودو و البوتاسيوم و الchlorideالسوديوم زي ما
+
+10
+00:00:55,730 --> 00:00:59,870
+واضح أنه فيه انخفاض مصيرته السوديوم البوتاسيوم
+
+11
+00:00:59,870 --> 00:01:05,810
+طبيعي الكلورايد برضه اللي هو منخفض ال total CO2
+
+12
+00:01:05,810 --> 00:01:15,350
+منخفض 14 اليوريا فيها ارتفاع في اليوريا وفي
+
+13
+00:01:15,350 --> 00:01:21,390
+الكرياتينين كمان كنا مرتفعين والجلوكوز مرتفع بشكل
+
+14
+00:01:21,390 --> 00:01:28,780
+كبير1063 milligram per deciliter و ال pH في عندنا
+
+15
+00:01:28,780 --> 00:01:33,220
+انخفاض في ال pH اللي هو 7.18 يعني في عندنا
+
+16
+00:01:33,220 --> 00:01:40,400
+acidosis موجود طبعا من ال من
+
+17
+00:01:40,400 --> 00:01:44,240
+اللي هو ال presentation لأ ال case طفل صغير عشر
+
+18
+00:01:44,240 --> 00:01:51,850
+سنين عمره السكر مرتفع بشكل كبيرعنا اللي هو الـ pH
+
+19
+00:01:51,850 --> 00:01:56,330
+من الخفضة طبعا، في عنده Acidosis والـ CO2 طبعا من
+
+20
+00:01:56,330 --> 00:02:01,550
+الخفضة فيعني غالبا الطفل هذا بعد الارتفاع الكبير
+
+21
+00:02:01,550 --> 00:02:04,590
+بالجلوكوز في عنده اللي هو الـ Type I Diabetes
+
+22
+00:02:04,590 --> 00:02:08,670
+Mellitus واحنا قولنا من ال complications اللي هو
+
+23
+00:02:08,670 --> 00:02:16,260
+ال acute يعني لـ Type I اللي بيصير في عنااللي هو
+
+24
+00:02:16,260 --> 00:02:22,220
+ketoacidosis بيصير فيه ketoacidosis يبقى انبين ان
+
+25
+00:02:22,220 --> 00:02:26,780
+الحالة هذه في عندنا اللي هو لبادة الـ ketoacidosis
+
+26
+00:02:26,780 --> 00:02:31,860
+الآن في اللباد الـ ketoacidosis ده several
+
+27
+00:02:31,860 --> 00:02:35,260
+metabolic arrangements في عندنا العديد من اللي هو
+
+28
+00:02:35,260 --> 00:02:37,660
+التغيرات اللي بتصير بما يتعلق بالـ metabolism
+
+29
+00:02:37,660 --> 00:02:44,140
+للكربوعيدرات لبروتينز لالـ lipidsبالنسبة لـ
+
+30
+00:02:44,140 --> 00:02:49,260
+Carbohydrates، علنا إذا الإنسلين موجود بشكل طبيعي،
+
+31
+00:02:49,260 --> 00:02:54,260
+الإنسلين يدفع إلى تغيير الجلوكوز وإيجلايكوجين
+
+32
+00:02:54,260 --> 00:03:00,180
+الهيباتيكي، إذا الإنسلين موجود، تمام؟ الآن في
+
+33
+00:03:00,180 --> 00:03:03,480
+الـDiabetic Ketoacidosis، انسفشن الإنسلين يسبب في
+
+34
+00:03:03,480 --> 00:03:06,930
+انهيبشة الإيجلايكوجين، مش موجود عند الإنسليناللي
+
+35
+00:03:06,930 --> 00:03:11,830
+فعلياً لجلوكوز مافيش إشي اللي يدخله إلى داخل
+
+36
+00:03:11,830 --> 00:03:15,410
+الخلايا عشان هيك زي ما شوفنا الجلوكوز مرتفع بشكل
+
+37
+00:03:15,410 --> 00:03:21,650
+كبير في البلازمة 1260 وبالتالي اللي هو الـ
+
+38
+00:03:21,650 --> 00:03:26,090
+hyperglycemia اللي بشكل كبير الموجودة بالنسبة للـ
+
+39
+00:03:26,090 --> 00:03:32,430
+limitمتابوليزم انسلين برضه يفتح ليبوجينيسيا إذا
+
+40
+00:03:32,430 --> 00:03:36,850
+الانسلين موجود برضه بيعمل هو طبعا اللي هو تصنيع
+
+41
+00:03:36,850 --> 00:03:41,670
+الدهون و induction لتصنيع الدهون لكن في ال DKA
+
+42
+00:03:41,670 --> 00:03:45,530
+insufficient insulin leads to lipolysis with the
+
+43
+00:03:45,530 --> 00:03:50,710
+production of glycerol and fatty acids لأن ما زال
+
+44
+00:03:50,710 --> 00:03:56,050
+الانسلين مش موجود تمام بيصير في عندنا الورليز ل
+
+45
+00:03:57,680 --> 00:04:01,440
+الجلوكوز من الكبت يعني عن طريق اللي هو
+
+46
+00:04:01,440 --> 00:04:04,880
+glucogenolysis والجلوكو نيوجينيسيس تمام لأن
+
+47
+00:04:04,880 --> 00:04:08,380
+الجلوكو نيوجينيسيس عندنا اللي هو طبعا يعني تصنيع
+
+48
+00:04:08,380 --> 00:04:11,660
+الجلوكوز from non-carbohydrate sources زي اللي هو
+
+49
+00:04:11,660 --> 00:04:15,700
+الليبت وايضا زي البروتينز تمام؟ يعني بيصير في
+
+50
+00:04:15,700 --> 00:04:21,600
+عندنا ليبوليزيز وبيصير طبعا اللي هو إنتاج لجليسرول
+
+51
+00:04:21,600 --> 00:04:26,160
+وفات الأسدوالـ Fatty acids are further metabolized
+
+52
+00:04:26,160 --> 00:04:30,420
+for energy هبص فينا Oxidation لـ الـ Fatty acids
+
+53
+00:04:30,420 --> 00:04:35,840
+وبينتجهان عندنا الـ Ketones المختلفة الـ Beta
+
+54
+00:04:35,840 --> 00:04:39,560
+-hydroxybutyrate وعندنا الـ Acetostate وعندنا
+
+55
+00:04:39,560 --> 00:04:46,260
+أيضًا برضه الـ Acetone فهدول التلاتة Ketoneأو الـ
+
+56
+00:04:46,260 --> 00:04:49,440
+Ketones اللي بينتجوا عندنا أيضًا الـ Deranged
+
+57
+00:04:49,440 --> 00:04:53,800
+Protein Metabolism برضه Insufficient Insulin Leads
+
+58
+00:04:53,800 --> 00:04:56,580
+to Proteolysis زي ما قلنا لأن فيه Gluconeogenesis
+
+59
+00:04:56,580 --> 00:05:00,920
+حيصير وبالتالي بيصير عندنا Breakdown لبروتينز عشان
+
+60
+00:05:00,920 --> 00:05:07,140
+يتم استخدام الـ Amino Acids في الحصول على طاقة
+
+61
+00:05:07,140 --> 00:05:10,500
+ويبقى
+
+62
+00:05:10,500 --> 00:05:12,920
+Leads to Proteolysis الـ Negative Nitrogen Balance
+
+63
+00:05:13,770 --> 00:05:17,570
+بيصير Negative Nitrogen Balance بشكل طبيعي بيكون
+
+64
+00:05:17,570 --> 00:05:24,630
+فينا الـ Nitrogen الداخل يتطالع لأن في هذه الحالة
+
+65
+00:05:24,630 --> 00:05:27,850
+بيصير فينا Negative Nitrogen Balance إيش يعني؟
+
+66
+00:05:27,850 --> 00:05:33,710
+يعني بيصير فينا اللي طالع أكتر من اللي داخل طيب
+
+67
+00:05:33,710 --> 00:05:37,050
+برضه اللي بيصير فينا Electrolyte Imbalances
+
+68
+00:05:37,050 --> 00:05:40,790
+Hyperglycemia may lead to osmotic dialysis and
+
+69
+00:05:40,790 --> 00:05:47,130
+urinary sodium lossلأن الجلوكوز أزموتيكي أكتر،
+
+70
+00:05:47,130 --> 00:05:55,170
+يعني لو أنا عندي جلوكوز، فيه عندنا الميّه، زي الـ
+
+71
+00:05:55,170 --> 00:06:00,610
+Sodium مثلا برضه، يبدأ
+
+72
+00:06:00,610 --> 00:06:04,390
+عندنا الآن لما بيصير، يرتفع، زي ما شوفنا عندنا
+
+73
+00:06:04,390 --> 00:06:10,970
+ارتفاع بشكل كبيرللـ Glucose وزي ما انتوا عارفين ان
+
+74
+00:06:10,970 --> 00:06:15,270
+الـ threshold لـ Glucose Reabsorption في الكدني هو
+
+75
+00:06:15,270 --> 00:06:20,210
+تقريبا 180 يبقى عندنا 1260 يبقى أكيد في عندنا خروج
+
+76
+00:06:20,210 --> 00:06:26,230
+لكميات كبيرة من ال glucose عن طريق ال urine ومازال
+
+77
+00:06:26,230 --> 00:06:29,370
+osmotically active يبقى هيطلع معاه كمان أيش كميات
+
+78
+00:06:29,370 --> 00:06:32,410
+كبيرة من الميه عشان هيك عند هذا الطفل كان في
+
+79
+00:06:32,410 --> 00:06:36,930
+polyuria في اللي هو urination بشكل اللي هو كبيرو
+
+80
+00:06:36,930 --> 00:06:41,230
+هذا اللي أدى إلى الواء ال polydipsy حدوث الوثاسة
+
+81
+00:06:41,230 --> 00:06:47,370
+لأنه لما بيفقد كميات كبيرة من الميه هذا هيغير من
+
+82
+00:06:47,370 --> 00:06:52,110
+الواء ال osmolality تمام؟ وبالتالي هيصير فيه إحساس
+
+83
+00:06:52,110 --> 00:06:59,470
+في العطش عند هذا الطفلده Sodium Depletion لان اذا
+
+84
+00:06:59,470 --> 00:07:02,530
+بقولنا بيصير في عنا برضه Sodium Loss Sodium
+
+85
+00:07:02,530 --> 00:07:06,410
+Depletion father worsened by vomiting كمان ال
+
+86
+00:07:06,410 --> 00:07:09,450
+vomiting اللي عند هذا الطفل برضه هذا زاد مشكلة
+
+87
+00:07:09,450 --> 00:07:14,810
+اللي هو فقدان Sodium عند الطفلHowever,
+
+88
+00:07:14,930 --> 00:07:20,010
+hypermetribia is a common finding in DTA بحيث أن
+
+89
+00:07:20,010 --> 00:07:25,010
+الصوديوم منخفض لكن ممكن في حالات أخرى نلاقي أن
+
+90
+00:07:25,010 --> 00:07:30,190
+الصوديوم مرتفع، common finding when dehydration
+
+91
+00:07:30,190 --> 00:07:37,770
+predominates over sodium lossلأن هنا في عندي فقد
+
+92
+00:07:37,770 --> 00:07:42,370
+لسوائل بكمية كبيرة الان في عندي فقد للسوديوم لكن
+
+93
+00:07:42,370 --> 00:07:49,570
+فقد الميه أكبر من فقد السوديوم تمام؟ وبالتالي كمية
+
+94
+00:07:49,570 --> 00:07:55,170
+السوديوم الموجودة عندى تمام؟ بتصير دايبة في كمية
+
+95
+00:07:55,170 --> 00:07:59,630
+أقل من الميه يبقى ال concentration بترتفع تمام؟
+
+96
+00:07:59,630 --> 00:08:04,990
+الجهة اللي في عندنا اللي هو relativeIncrease يعني
+
+97
+00:08:04,990 --> 00:08:07,950
+زي كان عندى ال Sodium كمية Sodium مثلا على سبيل
+
+98
+00:08:07,950 --> 00:08:16,190
+المثال واحد اجرام دايبة مثلا في لتر الآن صار عندى
+
+99
+00:08:16,190 --> 00:08:22,110
+point تسعة اجرام دايب في نص لتريبقى صار فيه أن دي
+
+100
+00:08:22,110 --> 00:08:25,250
+فقد لأ الميه كمية كبيرة فقد للصوديوم لكن مقاومة
+
+101
+00:08:25,250 --> 00:08:30,090
+بالميه أقل يبقى هذا أدى إلى ارتفاع في الواقع أو
+
+102
+00:08:30,090 --> 00:08:32,910
+بيأد يعني عادة إلى ارتفاع في ال sodium
+
+103
+00:08:32,910 --> 00:08:36,230
+concentration لكن زي ما قلنا هان الحالة أنه في
+
+104
+00:08:36,230 --> 00:08:39,990
+vomiting ف ال vomiting هذا كمان أدى إلى فقد لأ
+
+105
+00:08:39,990 --> 00:08:43,370
+الصوديوم لأن كان فيه أن الصوديوم شويه أقل من
+
+106
+00:08:43,370 --> 00:08:47,590
+الطبيعةأسيدوزيات مرتبطة مع الـDKA تسبب في تغيير
+
+107
+00:08:47,590 --> 00:08:52,350
+البوتاسيوم بشكل أكتر بشكل سلوكي يتسبب في تغيير
+
+108
+00:08:52,350 --> 00:08:58,230
+الهيبركاليميا الان من ميكانيزات التغيير
+
+109
+00:08:58,230 --> 00:09:06,070
+للأسيدوزيات أن بيصير في عندي تغيير للبوتاسيوم لما
+
+110
+00:09:06,070 --> 00:09:11,370
+يكون في عندي أسيدوزيات بيصير فيه دخول للهيدرين
+
+111
+00:09:11,370 --> 00:09:17,730
+أيون إلى داخل الـred blood cellsعشان نقلل من الـ
+
+112
+00:09:17,730 --> 00:09:21,930
+hydrogen ions الموجودة في البلازمة يعني نحاول نعدل
+
+113
+00:09:21,930 --> 00:09:25,710
+من الانخفاض في الـ pH اللي صار يبقى الـ hydrogen
+
+114
+00:09:25,710 --> 00:09:30,090
+ions بتدخل إلى داخل الـ red blood cellsطبعا كما
+
+115
+00:09:30,090 --> 00:09:33,530
+تعرفون أن هناك الـ Electric Neutrality يعني دائما
+
+116
+00:09:33,530 --> 00:09:37,030
+يجب أن يكون عندي عدد الـ Ions الموجة ما بيساوي عدد
+
+117
+00:09:37,030 --> 00:09:39,950
+ال Ions السالبة، يبقى إذا كانت خلال الـ Hydrogen
+
+118
+00:09:39,950 --> 00:09:43,070
+Ions اللي موجة إلى داخل الخلية، يبقى لازم يطلع
+
+119
+00:09:43,070 --> 00:09:46,830
+عندي اللي هو Positive Ion، أيش اللي بيطلع؟ الـ
+
+120
+00:09:46,830 --> 00:09:52,110
+Potassium اللي بيطلع، تمام؟يدخل هيدروجين آيون
+
+121
+00:09:52,110 --> 00:09:55,390
+وبالتالي بنقلل من الهيدروجين آيون وبالتالي بنحسن
+
+122
+00:09:55,390 --> 00:10:00,310
+من البيئات وبطلع عندي اللي هو بوتاسيوم however
+
+123
+00:10:00,310 --> 00:10:03,830
+because potassium is also lost renally and extra
+
+124
+00:10:03,830 --> 00:10:08,370
+renally total body potassium is often depleted لأن
+
+125
+00:10:08,370 --> 00:10:12,010
+برضه بهذا الحالة كان أن البوتاسيوم طبيعي
+
+126
+00:10:12,010 --> 00:10:17,590
+البوتاسيوم 75.2طبعا، لكن يعني برضه ممكن يكون فيه
+
+127
+00:10:17,590 --> 00:10:20,410
+عندنا hyperkalemia لكن زي ما قلنا إنه في عندنا
+
+128
+00:10:20,410 --> 00:10:25,730
+loss للبوتاسيوم عن طريق ال kidney وعندنا برضه عن
+
+129
+00:10:25,730 --> 00:10:30,310
+طريق ال vomiting وبالتالي يعني ماكانش عندنا ارتفاع
+
+130
+00:10:30,310 --> 00:10:32,030
+في البوتاسيوم، كان البوتاسيوم ال concentration
+
+131
+00:10:32,030 --> 00:10:38,000
+تبعته اللي هو طبيعيالأن هناك ملاحظة أن هذه الحالات
+
+132
+00:10:38,000 --> 00:10:41,900
+أن الشكر مرتفع بشكل كبير لأن من العلاج اللي بيعطوه
+
+133
+00:10:41,900 --> 00:10:47,080
+لهذا المريض لازم يعطوه insulin تمام؟ عشان يخفضوا
+
+134
+00:10:47,080 --> 00:10:51,560
+من مستوى السكر الآن المشكلة أن ال insulin therapy
+
+135
+00:10:51,560 --> 00:11:01,400
+هذه ممكن تؤدي إلى hypokalemiaلأن الإنسولين يزيد من
+
+136
+00:11:01,400 --> 00:11:04,840
+دخول البوتاسيوم إلى داخل الخلايا
+
+137
+00:11:09,780 --> 00:11:13,240
+الدخول اللي هو الـ Potassium بيزيد من اللي هو الـ
+
+138
+00:11:13,240 --> 00:11:17,140
+ATP اللي هو الـ Sodium Potassium Bump Activity
+
+139
+00:11:17,140 --> 00:11:20,600
+وبالتالي بيزيد من دخول الـ Potassium إلى داخل
+
+140
+00:11:20,600 --> 00:11:24,660
+الخلية وبالتالي ممكن مع العلاج اللي يُعطيها بيشير
+
+141
+00:11:24,660 --> 00:11:28,660
+بيكون فيه مراقبة مستمرة للمريض لأن هذا ممكن يؤدي
+
+142
+00:11:28,660 --> 00:11:30,760
+إلى حدوث Hypo-Kelling
+
+143
+00:11:32,850 --> 00:11:36,170
+بالإضافة إلى البوتاسيوم، الفوسفات أيضًا تتحرك بشكل
+
+144
+00:11:36,170 --> 00:11:42,350
+إنتراليوني لتعامل مع الإنسلين وبالتالي برضه ممكن
+
+145
+00:11:42,350 --> 00:11:46,010
+أن يكون هناك انخفاض في البوتاسيوم وهيبوفسفوتيميا
+
+146
+00:11:46,010 --> 00:11:49,990
+يبقى أثناء العلاج لابد من المراقبة المستمرة
+
+147
+00:11:49,990 --> 00:11:56,200
+لإلكتروليتز عند المرضىطبعا هنا برضه من الشغلات
+
+148
+00:11:56,200 --> 00:11:59,680
+اللي بتتأثر عندنا اللي هو الـ acid-base balance زي
+
+149
+00:11:59,680 --> 00:12:04,120
+ما شفنا أن البيئة كانت منخفض كان في عندنا اللي هو
+
+150
+00:12:04,120 --> 00:12:07,840
+الـ Acidosis production of ketoacids in BKA causes
+
+151
+00:12:07,840 --> 00:12:13,760
+high anion gap metabolic acidosis with beta
+
+152
+00:12:13,760 --> 00:12:17,480
+hydroxybutyrate more abundant than acetoacetate
+
+153
+00:12:18,920 --> 00:12:22,380
+يبقى .. زي ما قلنا أنه عندنا بيصير ليبوليزيز بيصير
+
+154
+00:12:22,380 --> 00:12:25,880
+فيه الـ oxidation لفتي أسد بيصير عندنا إنتاج
+
+155
+00:12:25,880 --> 00:12:31,960
+لكيتون أسد أو الكيتون أسد هذه اللي بيصير في عندنا
+
+156
+00:12:31,960 --> 00:12:38,260
+أو بتلعب دور في انخفاض الـ pH وزيادة الـ hydrogen
+
+157
+00:12:38,260 --> 00:12:46,680
+ions في عندنا اللي هو causes high anion gapحنحكي
+
+158
+00:12:46,680 --> 00:12:49,520
+عن الـ Anions جاب لما نحكي عن الـ Electrolytes لأن
+
+159
+00:12:49,520 --> 00:12:54,800
+الـ Anions جاب عبارة عن الـ Unmeasured
+
+160
+00:12:54,800 --> 00:12:59,560
+anions مطروح منها الـ Unmeasured كتائز و المفروض
+
+161
+00:12:59,560 --> 00:13:04,780
+تكون يعني في إليها reference interval معين إبداعا
+
+162
+00:13:04,780 --> 00:13:09,080
+يكون فينا ارتفاع في الـ Anions جاب لأن صار فينا
+
+163
+00:13:09,080 --> 00:13:15,870
+زيادة في الـ Anions الموجودة عند المريضطيب الـ
+
+164
+00:13:15,870 --> 00:13:19,650
+Lactic Acid برضه production اللي ممكن برضه تزيد
+
+165
+00:13:19,650 --> 00:13:25,750
+بسبب الورفور سيركليشن and شوكر هذه برضه اللي ممكن
+
+166
+00:13:25,750 --> 00:13:30,230
+تزيد من ال metabolic acidولي changes in urea و
+
+167
+00:13:30,230 --> 00:13:33,170
+الكريتالين لأن زى ما شوفنا فيها ان ارتفاع في اليرة
+
+168
+00:13:33,170 --> 00:13:37,490
+و الكريتالين طبعا ليش لأنهازي ما شوفنا انه في
+
+169
+00:13:37,490 --> 00:13:41,830
+dehydration في فقد الكيميات الكبيرة من الميه يبقى
+
+170
+00:13:41,830 --> 00:13:47,910
+عند ال blood volume قلق صحيح؟ يبقى في هذه الحالة
+
+171
+00:13:47,910 --> 00:13:54,150
+في عندنا الـ Prerenal Azotemia زي ما انتوا عارفين
+
+172
+00:13:54,820 --> 00:13:59,400
+اللي هو الارتفاع في اليولياء في تلت أسباب فيها
+
+173
+00:13:59,400 --> 00:14:01,460
+اللي هو الـ pre-renal و الرينال و ال post-renal
+
+174
+00:14:01,460 --> 00:14:06,700
+طبعا حالات اللي هو النقص في blood volume أو إذا
+
+175
+00:14:06,700 --> 00:14:10,060
+كان في عنا مشكلة في القلب وبالتالي يعني تضافة
+
+176
+00:14:10,060 --> 00:14:15,940
+قدامها ده بيعمللي ما يسمى بـ pre-renal أزوتيميا
+
+177
+00:14:17,320 --> 00:14:20,100
+الـ Extremely High Plasma Concentrations of
+
+178
+00:14:20,100 --> 00:14:23,180
+Ketones May Cause Positive Interference In Some
+
+179
+00:14:23,180 --> 00:14:27,420
+Laboratory Methods For Measuring Creatinine كمان
+
+180
+00:14:27,420 --> 00:14:31,560
+الارتفاع في الـ Ketones حتى الارتفاع بالجلوكوز
+
+181
+00:14:31,560 --> 00:14:39,480
+ممكن يعمل interferenceفيه الوالجافي method لفحص
+
+182
+00:14:39,480 --> 00:14:43,000
+الكرياتينينة اذا ما تعرفين ان في عندنا ممكن
+
+183
+00:14:43,000 --> 00:14:46,620
+interference في بعض الفحصات اشي بيأثر على اشي زي
+
+184
+00:14:46,620 --> 00:14:51,160
+hemolysis مثلا زي لو الليبيليا زيادة الليبيدز ممكن
+
+185
+00:14:51,160 --> 00:14:54,920
+تأثر على بعض الفحصات اه بجهان باليروبيل بجهان في
+
+186
+00:14:54,920 --> 00:14:58,980
+عندنا الزيادة في ال ketone bubbles و ال glucose
+
+187
+00:14:58,980 --> 00:15:05,430
+هيأثر على الفحص الكرياتينيهذا الفيجور يوضح أن
+
+188
+00:15:05,430 --> 00:15:08,950
+الأمور
+
+189
+00:15:08,950 --> 00:15:12,910
+المختلفة اللي بتتغير على مستوى اللي هو الـ
+
+190
+00:15:12,910 --> 00:15:16,510
+Endocrine في أنها طبعاً زي ما مازال الـ Type 1
+
+191
+00:15:16,510 --> 00:15:20,930
+يبقى Absolute Deficiency وإنسلين وبالتالي هذا
+
+192
+00:15:20,930 --> 00:15:23,850
+بيقدر إلى ارتفاع في ال counter regulatory hormones
+
+193
+00:15:23,850 --> 00:15:28,490
+زي ما قلنا إن بيصير فينا زيادةفي اللواء الـ
+
+194
+00:15:28,490 --> 00:15:32,530
+hyperglycemic hormones زي الـ glucagon و زي اللواء
+
+195
+00:15:32,530 --> 00:15:35,390
+الـ hormones الأخرى الآن الـ metabolic
+
+196
+00:15:35,390 --> 00:15:38,230
+abnormalities على مستوى الـ carbohydrates بيصير
+
+197
+00:15:38,230 --> 00:15:40,850
+فيها زيادة في الـ glucogenolysis و بيصير فيها
+
+198
+00:15:40,850 --> 00:15:45,450
+زيادة في الـ gluconeogenesis بالإضافة للانخفاض في
+
+199
+00:15:45,450 --> 00:15:50,530
+الـ glucose uptake تمام؟ و هذه كلها طبعا بالنهاية
+
+200
+00:15:50,530 --> 00:15:53,210
+بتؤدي إلى hyperglycemia
+
+201
+00:15:54,700 --> 00:15:59,060
+عنا على مستوى البروتينز اللي بتزيد اللي هو
+
+202
+00:15:59,060 --> 00:16:03,140
+البروتيولوجيز تمام؟ وبالتالي هذا بيزيد من ال
+
+203
+00:16:03,140 --> 00:16:08,420
+plasma amino acid عنا الفات بيزيد ال lipolysis و
+
+204
+00:16:08,420 --> 00:16:11,480
+برضه بيزيد ال ketogenesis اللي هو production of
+
+205
+00:16:11,480 --> 00:16:16,880
+ketoneوبالتالي هذا بيزيد من البلازمة اللي وفّيه
+
+206
+00:16:16,880 --> 00:16:20,520
+fatty acids وبيزيد أيضًا من ال ketone bodies
+
+207
+00:16:20,520 --> 00:16:23,860
+التغيرات اللي بتصير بالبلازمة زي ما قلنا
+
+208
+00:16:23,860 --> 00:16:27,480
+hyperglycemia بتزيد عندنا اللي هو البلازمة
+
+209
+00:16:27,480 --> 00:16:31,120
+osmolality لأن عندنا زي ما قلنا ال glucose
+
+210
+00:16:31,120 --> 00:16:34,300
+osmetically active وبالتالي بيزيد عندنا اللي هو
+
+211
+00:16:34,300 --> 00:16:40,900
+البلازمة osmolalityبتزيد الـ Amino Acids وبتزيد
+
+212
+00:16:40,900 --> 00:16:45,160
+برضه إن ما زال الـ Amino Acids زادت يبقى عندنا
+
+213
+00:16:45,160 --> 00:16:49,540
+اليوريا برضه هتزيد و هذا سبب آخر لزيادة اليوريا
+
+214
+00:16:49,540 --> 00:16:54,160
+غير الـ dehydrationإنه قوية اللي هو الـ prelineal
+
+215
+00:16:54,160 --> 00:16:57,260
+azotemia يعني صار فينا زيادة في البلازمة أمانو أسس
+
+216
+00:16:57,260 --> 00:17:00,020
+وبالتالي زي ما انتوا عارفين بلازمة اللي أمانو أسس
+
+217
+00:17:00,020 --> 00:17:04,420
+ماتتخزنش إذا فينا surplus بيصلها إيش break down و
+
+218
+00:17:04,420 --> 00:17:07,980
+ال break down للأمانو أسس إيش بينتج عنه؟ بينتج عنه
+
+219
+00:17:07,980 --> 00:17:12,400
+اللي هو يوريا زيادة بيه اللي هو البلازمة فيه فاتق
+
+220
+00:17:12,400 --> 00:17:16,940
+أسس وزيادة برضه بيه ال ketone bodies طيب ال
+
+221
+00:17:16,940 --> 00:17:21,500
+physiological consequencesالـ Hyperglycemia ستعمل
+
+222
+00:17:21,500 --> 00:17:27,600
+لـ Glucosuria سيكون هناك خروج لجلوكوز عن طريق
+
+223
+00:17:27,600 --> 00:17:32,360
+اليورين وهنا سيكون هناك Osmotic Diarsis سنقول أن
+
+224
+00:17:32,360 --> 00:17:35,420
+الجلوكوز أسمه Osmotically Active سيكون هناك خروج
+
+225
+00:17:35,420 --> 00:17:38,740
+لكميات كبيرة من الجلوكوز وهذا سيسحب معاه كميات
+
+226
+00:17:38,740 --> 00:17:44,340
+كبيرة من الميه في اليورين أيضا وهذا برضه سيؤدي إلى
+
+227
+00:17:44,340 --> 00:17:48,840
+فقد وسيعمل لنا Unbalance لأنه يصبح فقد لإلكترولايت
+
+228
+00:17:50,670 --> 00:17:55,370
+وبالنهاية سيصبح هناك hypovolemia انقفاض في blood
+
+229
+00:17:55,370 --> 00:17:59,950
+volume وبالتالي الهو dehydration ال plasma
+
+230
+00:17:59,950 --> 00:18:04,510
+osmolality اللى صارت في البلازمة زى ما تعرفين ال
+
+231
+00:18:04,510 --> 00:18:09,010
+hypothalamus مستجيل لل osmolality اللى في الدم لأن
+
+232
+00:18:09,010 --> 00:18:13,820
+لما بزيد هنا ال osmolality ال hypothalamusالمفروض
+
+233
+00:18:13,820 --> 00:18:18,080
+ايش بيعمل؟ اللي هو بزيد من إفراز الـ antihydrated
+
+234
+00:18:18,080 --> 00:18:23,060
+hormone عشان يصبح عنده more absorption للميّه
+
+235
+00:18:23,060 --> 00:18:29,180
+وبيعطي إحساس بالعطش يبقى هان في عندنا اللي هو
+
+236
+00:18:29,180 --> 00:18:35,600
+thirst هان اللي في عندنا يوريميا اللي هو ارتفاع في
+
+237
+00:18:35,600 --> 00:18:49,100
+مستوى اليوريا والـhypovolemia اللي صاربالتالي قلل
+
+238
+00:18:49,100 --> 00:18:54,340
+من الـ Glomerular Filtration Rate وكما تعرفون كلما
+
+239
+00:18:54,340 --> 00:18:59,120
+قلت Glomerular Filtration Rate كل معناه ما الـ
+
+240
+00:18:59,120 --> 00:19:02,580
+Substances المختلفة اللي بيستخدم ال filtration قلت
+
+241
+00:19:02,580 --> 00:19:08,870
+وبالتالي حصل ارتفاع في إدامإنخفاض في الـ Renal
+
+242
+00:19:08,870 --> 00:19:12,610
+Hydrogen Execration وبرضه إنخفاض في الـ Glomeral
+
+243
+00:19:12,610 --> 00:19:17,590
+Filtration Rate هذا قلل من الـ Hydrogen Ion
+
+244
+00:19:17,590 --> 00:19:21,350
+Execration لأنه المفروض أنا لما برتفع عندي الـ
+
+245
+00:19:21,350 --> 00:19:25,930
+Hydrogen Ions في الدم المفروض بيصير في عندي more
+
+246
+00:19:25,930 --> 00:19:30,240
+Execration of Hydrogen Ionsالأن مع انخفاض اللي حصل
+
+247
+00:19:30,240 --> 00:19:34,020
+في الـ Glucose Reception Rate بجهة أقل من الـ
+
+248
+00:19:34,020 --> 00:19:36,340
+Execretion اللي لها الـ hydrogen ions و برضه ساعد
+
+249
+00:19:36,340 --> 00:19:44,080
+في حدوث الـ Acidoses بالإضافة لكيتوناتالتي ارتفعت
+
+250
+00:19:44,080 --> 00:19:50,640
+و الـ Ketones برضه أست وبالتالي برضه بتزيد من ال
+
+251
+00:19:50,640 --> 00:19:53,440
+release ال hydrogen ions وبالتالي بتلعب دور في ال
+
+252
+00:19:53,440 --> 00:19:58,780
+acidoses اللي صارت طيب في المرضى هدول اللي بيكون
+
+253
+00:19:58,780 --> 00:20:02,560
+عندهم ketoacidoses لو جينا جربنا و شمينا النفس
+
+254
+00:20:02,560 --> 00:20:09,370
+بتاعهم بنجد نفس فرووتي هيك فيه ريحة عطرة حلوةالسبب
+
+255
+00:20:09,370 --> 00:20:12,770
+هو الـ Ketone Body برضه اللي هو الـ Acetone اللي
+
+256
+00:20:12,770 --> 00:20:17,830
+بيسمله Exhalation أو خروج مع اللي هو الزفير
+
+257
+00:20:17,830 --> 00:20:23,070
+الارتفاع في الـ Ketone Bodies برضه ممكن هو اللي
+
+258
+00:20:23,070 --> 00:20:27,490
+عمل الـ Vomiting هو سبب الـ Vomiting تمام؟ لأن الـ
+
+259
+00:20:27,490 --> 00:20:31,290
+Ketones عبارة عن اللي هو Updated Subresence
+
+260
+00:20:31,290 --> 00:20:38,920
+وبيؤدوا إلى نوزياوبالتالي الـ vomiting هو سبب
+
+261
+00:20:38,920 --> 00:20:45,060
+الارتفاع في الكيوتون باطسي بالنسبة للـ Acidoses
+
+262
+00:20:45,060 --> 00:20:48,460
+احنا قلنا انه صار في انا Acidoses الان هدول
+
+263
+00:20:48,460 --> 00:20:54,140
+الأشخاص بيكون فيه النفس عندهم سريع اللي بيصير فيه
+
+264
+00:20:54,140 --> 00:20:56,080
+hyperventilation
+
+265
+00:20:59,350 --> 00:21:02,610
+سبب الـ hyperventilation هي عبارة عن الـ
+
+266
+00:21:02,610 --> 00:21:07,710
+compensation mechanism لأننا سنحكي عليها بالتفصيل
+
+267
+00:21:07,710 --> 00:21:11,370
+هذه لما نحكي على الـ acid imbalance لما يكون لدي
+
+268
+00:21:11,370 --> 00:21:14,830
+متابولك أسيدوزيز ماهو ال compensation mechanism
+
+269
+00:21:14,830 --> 00:21:20,630
+بتكون عن طريق الجهاز اللي مش مصابب، في هذه الحالة
+
+270
+00:21:20,630 --> 00:21:24,670
+بتكون ال lungs يتجه ال lungs بتعمل ال compensation
+
+271
+00:21:24,670 --> 00:21:31,480
+بتحاول التعدلمن اللي هو الـ pH طبعا هذا عندنا اللي
+
+272
+00:21:31,480 --> 00:21:34,920
+هو في المعادلة بحثت عنها مرة عليك بالصدق انها لأ
+
+273
+00:21:34,920 --> 00:21:43,580
+الان احنا عندنا ال CO2 مع ال H2O بيعطيني H2CO3 هذا
+
+274
+00:21:43,580 --> 00:21:48,540
+بصيرله اللي هو تحليل لHCO3 و hydrogen ions طيب
+
+275
+00:21:48,540 --> 00:21:53,380
+الان لما انا بتفت عندى ال hydrogen ions طيب هنا
+
+276
+00:21:53,380 --> 00:22:04,190
+عندنا ال H2Oمع الـ CO2 قالوا بيعطينا H2CO3 هذي
+
+277
+00:22:04,190 --> 00:22:10,870
+بيصير لها الassociation لـ HCO3 و Hydrogen اللي هو
+
+278
+00:22:10,870 --> 00:22:16,650
+Iكمبنسيشن ميكانيزم لما يحدث فينا ارتفاع في الـ
+
+279
+00:22:16,650 --> 00:22:20,630
+hydrogen ions يحدث فيه hyperventilation ماهو
+
+280
+00:22:20,630 --> 00:22:24,690
+hyperventilation؟ يعني معدل التنفس بيزيد تمام؟ لما
+
+281
+00:22:24,690 --> 00:22:28,730
+معدل التنفس بيزيد، ماذا يحدث فينا؟ more exhalation
+
+282
+00:22:28,730 --> 00:22:33,390
+of CO2 يحدث فينا فقط لكميات أكبر من الـCO2، إذا
+
+283
+00:22:33,390 --> 00:22:40,020
+ماهو حدث لـCO2؟هينخفض تمام؟ هينزل لأن لما بنزل الـ
+
+284
+00:22:40,020 --> 00:22:44,440
+CO2 بيصير في عندنا المعادلة بتمشي بهذا الاتجاه
+
+285
+00:22:44,440 --> 00:22:52,020
+يبقى بيصير في عندي hydrogen ions ترتبط مع HCO3عشان
+
+286
+00:22:52,020 --> 00:22:55,800
+يعطينا H2CO3 عشان نعود اللي هو النقص اللي بالـCO2
+
+287
+00:22:55,800 --> 00:23:00,220
+اللي جاعد الجسم بتخلص منه يبقى احنا إيش بنعمل؟
+
+288
+00:23:00,220 --> 00:23:05,160
+جاعدين نتخلص من الـhydrogen ions الموجودة في
+
+289
+00:23:05,160 --> 00:23:12,400
+البلازمة طيب الكاسد التانية عنا
+
+290
+00:23:12,400 --> 00:23:18,080
+a 27 year old man was referred to the local
+
+291
+00:23:18,080 --> 00:23:22,630
+diabetic clinicيبقى الشاب عمره 27 سنة he had been
+
+292
+00:23:22,630 --> 00:23:26,590
+diagnosed as having type 2 diabetes malatus يعني
+
+293
+00:23:26,590 --> 00:23:31,690
+عنده ارتفاع في السكرويعني من الفحوصات اللي قاملوها
+
+294
+00:23:31,690 --> 00:23:34,070
+توصلوا إنه عنده type 2 diabetes myelitis three
+
+295
+00:23:34,070 --> 00:23:38,010
+years previously and his control was poor يعني
+
+296
+00:23:38,010 --> 00:23:42,330
+كانت تلت سنين له وتحكمه بالجلوكوز يعني مستويات
+
+297
+00:23:42,330 --> 00:23:46,710
+الجلوكوز دايما عنده إيش مرتفعة و الدليل إنه هي
+
+298
+00:23:46,710 --> 00:23:53,450
+عندنا برضه ال hemoglobin A1C 9.6% despite being on
+
+299
+00:23:53,450 --> 00:23:58,050
+an optimal dose of metforminالعلاج اللي كان بياخده
+
+300
+00:23:58,050 --> 00:24:03,170
+هذا المريض هو ال medformin طبعا هو المرضى السكري
+
+301
+00:24:03,170 --> 00:24:09,310
+يعني عادة أول شي بيبدوا معاهم ب diet ممكن exercise
+
+302
+00:24:09,310 --> 00:24:13,570
+تخريف وزن فترة لاجوا و الله انه لأ في شفاية ده و
+
+303
+00:24:13,570 --> 00:24:16,730
+لسه ال glucose مرتفع بيبدوا معاهم ب ال medformin
+
+304
+00:24:16,730 --> 00:24:21,830
+او ال medformin زي ما بتعرفيه بيعمل على تقليل ال
+
+305
+00:24:21,830 --> 00:24:28,600
+release of glucose from the liverالمشكلة عند مرضى
+
+306
+00:24:28,600 --> 00:24:32,200
+السكر أنه مع الارتفاع في الجلوكوز الموجود لأن
+
+307
+00:24:32,200 --> 00:24:41,580
+الكبد أيضًا بيزيد اللي هو بينتج الجلوكوز الآن الـ
+
+308
+00:24:41,580 --> 00:24:44,300
+general practitioner was wondering whether his man
+
+309
+00:24:44,300 --> 00:24:49,520
+needed to start on insulin يعني مع الـ poor
+
+310
+00:24:49,520 --> 00:24:56,030
+control للجلوكوز الموجودففكر إنه يبدأله بإنسلين
+
+311
+00:24:56,030 --> 00:25:01,690
+عدة أعضاء عائلات قريبة أيضًا كانوا مرتبطين بشكل
+
+312
+00:25:01,690 --> 00:25:04,970
+عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام
+
+313
+00:25:04,970 --> 00:25:10,210
+بشكل عام بشكل عام بشكل عام بشكل عام بشكل
+
+314
+00:25:10,210 --> 00:25:10,630
+عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام
+
+315
+00:25:10,630 --> 00:25:10,670
+بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل
+
+316
+00:25:10,670 --> 00:25:10,670
+عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام
+
+317
+00:25:10,670 --> 00:25:10,670
+بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل
+
+318
+00:25:10,670 --> 00:25:13,640
+عام بشكل عام بشكل عام بشكل عام بشكل عامالـ Body
+
+319
+00:25:13,640 --> 00:25:18,460
+Mass Index مش عالية يعني مش obese لأن هو 26 يعني
+
+320
+00:25:18,460 --> 00:25:24,700
+بيعتبر لأنه الطبيعي لغاية 24.9 تمام فهو 1.26 يعني
+
+321
+00:25:24,700 --> 00:25:31,320
+فعليا وزنه مش كتير فوق الوزن الطبيعي وضغطه طبيعي
+
+322
+00:25:31,320 --> 00:25:37,060
+وفي عنده family يعني history بأنه ال diabetes تمام
+
+323
+00:25:37,060 --> 00:25:41,580
+يعني المؤشرات بتدلش على أنه عنده بتاعته diabetes
+
+324
+00:25:41,580 --> 00:25:46,400
+follitisهذا اللي هو الشخص In view of the strong
+
+325
+00:25:46,400 --> 00:25:49,560
+family history of diabetes أكتر that he did not
+
+326
+00:25:49,560 --> 00:25:52,140
+fit the typical phenotype of type 2 diabetes
+
+327
+00:25:52,140 --> 00:25:56,000
+mellitus لأنه relatively young، not obese nor
+
+328
+00:25:56,000 --> 00:25:59,540
+motensive possibility of maturity against diabetes
+
+329
+00:25:59,540 --> 00:26:04,900
+of the young was raised وهذه فعليًا مشكلة العديد
+
+330
+00:26:04,900 --> 00:26:10,360
+من الأشخاص اللي فعليًا عندهم الموديبيتم تشكيزهم
+
+331
+00:26:10,360 --> 00:26:16,300
+خطأ على أنه عندهم type 2 diabetes folate طبعا اللي
+
+332
+00:26:16,300 --> 00:26:19,860
+.. اللي زي ما انتوا شايفين انه العلاج بيختلف يعني
+
+333
+00:26:19,860 --> 00:26:22,620
+هى هدا كان شخصيا على انه type 2 diabetes folate
+
+334
+00:26:22,620 --> 00:26:26,560
+بياخد علاج لكن فعليا فيه poor control لglucose
+
+335
+00:26:26,560 --> 00:26:30,460
+فدعم التشكيز السليم أكيد يعني بيصيح فينا better
+
+336
+00:26:30,460 --> 00:26:38,020
+management ل ال patientالان الموضي ممكن عن طريق
+
+337
+00:26:38,020 --> 00:26:42,940
+الـ Molecular Analysis Genotyping revealed a
+
+338
+00:26:42,940 --> 00:26:50,460
+mutation in the HNF1 Alpha-Gene وهذا الجين له
+
+339
+00:26:50,460 --> 00:26:54,500
+علاقة بالـ Beta-Cells و الـ Release of Insulin
+
+340
+00:26:54,500 --> 00:26:59,340
+والميوتاشيون في هذا الجين بيؤدي إلى Decrease
+
+341
+00:26:59,340 --> 00:27:05,330
+Release of Insulin from Beta-Cellsهذا هو المشكلة
+
+342
+00:27:05,330 --> 00:27:14,750
+عند هذا الملعب متفورمين كان موقفًا، والآن نريد شيء
+
+343
+00:27:14,750 --> 00:27:20,590
+فقط يزيد من إطلاق الإنسلين، هناك أدوية لدينا، وهذه
+
+344
+00:27:20,590 --> 00:27:24,990
+مرحلة بعد متفورمين، تعمل استيميلاش للبنكرياس ويزيد
+
+345
+00:27:24,990 --> 00:27:32,490
+من إطلاق الإنسلين، هذا ما كان محتاجه، وهو العلاج
+
+346
+00:27:33,140 --> 00:27:37,760
+يبيعطوه له دوز of glucoside تمام؟ هو عبارة عن
+
+347
+00:27:37,760 --> 00:27:43,300
+سالفونيوليا هذه مجموعة من الأدوية هذه الأدوية
+
+348
+00:27:43,300 --> 00:27:49,720
+بتزيد من اللي هو ال insulin secretion الكاسك تالتة
+
+349
+00:27:49,720 --> 00:27:53,920
+الدليمان was visited by his son and was found to
+
+350
+00:27:53,920 --> 00:28:00,100
+be semi-conscious جراجر كوير و ابنه زار و لجأ انه
+
+351
+00:28:00,100 --> 00:28:04,440
+مش مصح صحي زي كأنه مغيبينالقابلين كانوا يلاحظوا
+
+352
+00:28:04,440 --> 00:28:07,640
+عنه حوالي 10 أيام قبل ذلك. أخر مرة شفوه قبل عشر
+
+353
+00:28:07,640 --> 00:28:11,300
+أيام جلانه، when he had seemed well، كان فيش فيه
+
+354
+00:28:11,300 --> 00:28:13,600
+مشكلة ومباين طبيعي، he was admitted to hospital.
+
+355
+00:28:14,320 --> 00:28:17,860
+On examination, he appeared extremely dehydrated.
+
+356
+00:28:18,560 --> 00:28:21,760
+كان برضه فيه أندفع كبير للسوائل. Results of
+
+357
+00:28:21,760 --> 00:28:26,970
+biochemical investigations were as followsاليوريا
+
+358
+00:28:26,970 --> 00:28:33,510
+عندنا 38 ملي مول او 1006 ملي جرام بردساليتا اللي
+
+359
+00:28:33,510 --> 00:28:36,170
+في عندنا ارتفاع الكلية التانية الواحد و نصف برضه
+
+360
+00:28:36,170 --> 00:28:38,590
+في عندنا ارتفاع اللي في ارتفاع في اليوريا و
+
+361
+00:28:38,590 --> 00:28:41,810
+بالكلية التانية و هذا ما زال فيه dehydration زي ما
+
+362
+00:28:41,810 --> 00:28:44,770
+شوفنا بالحالة السابقة اللي ما زال فيه dehydration
+
+363
+00:28:44,770 --> 00:28:47,990
+اللي في عندنا اللي هو pre-renal ممكن أزوتياميا
+
+364
+00:28:47,990 --> 00:28:51,650
+ممكن هذه تكون اللي هو سبب الارتفاع في اليوريا و
+
+365
+00:28:51,650 --> 00:28:55,720
+الكلية التانيةعندنا الصوديوم في ارتفاع في الصوديوم
+
+366
+00:28:55,720 --> 00:29:02,340
+البوتاسيوم الطبيعي اللي برضه في انخفاض في اللي هو
+
+367
+00:29:02,340 --> 00:29:09,280
+الـ CO2 18% الجلوكوز برضه مرتفع بشكل كبير 1098
+
+368
+00:29:09,280 --> 00:29:13,820
+ميلي جرام بالديسليتر والـ Osmolality برضه عندنا
+
+369
+00:29:13,820 --> 00:29:17,060
+مرتفعة طبعا الناس اللي
+
+370
+00:29:23,780 --> 00:29:29,000
+مصابين بالتدو دا باسم Litas من ال complications
+
+371
+00:29:29,000 --> 00:29:32,580
+اللي ممكن تكون عندهم ال acute انه بيصير في عندهم
+
+372
+00:29:32,580 --> 00:29:38,940
+ال hyperosmolar non-ketonic اللي بيصير في عندهم
+
+373
+00:29:38,940 --> 00:29:45,660
+ارتفاع في ال osmolality تمام، لكن بيكونش فيه
+
+374
+00:29:45,660 --> 00:29:50,660
+ارتفاع في ال ketone bodies اه، يبقى هذا اللي هو
+
+375
+00:29:50,660 --> 00:29:58,020
+اللي بيفرقعشان هيك اللي هو الـ Ketones مهم انه
+
+376
+00:29:58,020 --> 00:30:02,780
+يعمل اللي هو اللي تفرقها يبقى فيه عنا سيفير
+
+377
+00:30:02,780 --> 00:30:07,360
+hyperglycemia وهذه هي اللي قدت الى ارتفاع الـ
+
+378
+00:30:07,360 --> 00:30:10,540
+osmolality لأن اللي قولنا اللي بيكون osmotically
+
+379
+00:30:10,540 --> 00:30:14,520
+active hyperglycemia has driven on osmotic
+
+380
+00:30:14,520 --> 00:30:20,420
+diuresis برضه نفس الفكرةوهي تسبب في اختلاف افلود
+
+381
+00:30:20,420 --> 00:30:23,040
+اكتسرا واختلاف افلود اكتسرا واختلاف افلود اكتسرا
+
+382
+00:30:23,040 --> 00:30:24,240
+واختلاف افلود اكتسرا واختلاف افلود اكتسرا واختلاف
+
+383
+00:30:24,240 --> 00:30:25,680
+افلود اكتسرا واختلاف افلود اكتسرا واختلاف افلود
+
+384
+00:30:25,680 --> 00:30:28,220
+اكتسرا واختلاف افلود اكتسرا واختلاف افلود اكتسرا
+
+385
+00:30:28,220 --> 00:30:33,400
+واختلاف افلود اكتسرا واختلاف افلود اكتسرا واختلاف
+
+386
+00:30:33,400 --> 00:30:39,460
+افلود اكتسرا واختلاف افلود اكتسرا واختلاف افلود
+
+387
+00:30:39,460 --> 00:30:45,390
+اكتسرا واختلاف افإنه بيصير فيه hyperlipidemia لكن
+
+388
+00:30:45,390 --> 00:30:48,950
+قلنا الـ vomiting هو كان سبب إنه صار فيه فقد له
+
+389
+00:30:48,950 --> 00:30:53,970
+اللي هو الـ Sodium Total CO2 is slightly reduced
+
+390
+00:30:53,970 --> 00:30:58,570
+due to the impaired renal function but it's not as
+
+391
+00:30:58,570 --> 00:31:00,150
+low as what we expected in the case of
+
+392
+00:31:00,150 --> 00:31:03,270
+ketoacidosis في الـ ketoacidosis اللي شوفنا كان
+
+393
+00:31:03,270 --> 00:31:06,090
+عندنا الـ CO2 ال concentration أقل بهيك بكتير،
+
+394
+00:31:06,090 --> 00:31:11,850
+بصبح؟ with result as abnormal as thisالشخص كان
+
+395
+00:31:11,850 --> 00:31:14,630
+مميزاً بالفعل ولكن في النهاية كان قادر على إعطاء
+
+396
+00:31:14,630 --> 00:31:19,770
+مثال يورين الذي أعطى تجارب خاطئة لكيتونات وما كانش
+
+397
+00:31:19,770 --> 00:31:23,450
+في عندهم كيتونات واحنا قلنا إن ال .. يعني ال
+
+398
+00:31:23,450 --> 00:31:30,030
+ketoacidosis عادة بتكون في مرضى ال type 1 تمام؟
+
+399
+00:31:30,030 --> 00:31:34,170
+لأن قلنا بيكون في عندنا absolute deficiency of
+
+400
+00:31:34,170 --> 00:31:39,370
+insulin وقلنا إن ال .. ال insulin اللي فيه عنده
+
+401
+00:31:39,370 --> 00:31:42,400
+negativeاللي هو effect على الـ release of
+
+402
+00:31:42,400 --> 00:31:47,040
+الجلوكاجون فالآن لما الإنسلين يكون مش موجود فهذا
+
+403
+00:31:47,040 --> 00:31:50,380
+بيزيد من اللي هو الجلوكاجون وبيزيد من الـ
+
+404
+00:31:50,380 --> 00:31:53,460
+gluconeogenesis و اللي هو الـ lipid oxidation و
+
+405
+00:31:53,460 --> 00:31:59,160
+بالتالي بيصير في أننا اللي هو الارتفاع في الـ
+
+406
+00:31:59,160 --> 00:32:02,780
+ketone bodies لكن في الtype 2 diabetes mellitus
+
+407
+00:32:02,780 --> 00:32:06,740
+هدول المرضى عندهم إنسلين، مظبوط؟ يعني لو في
+
+408
+00:32:06,740 --> 00:32:11,680
+deficiencyلكن الإنسولين موجود مش زي اللواء الـ
+
+409
+00:32:11,680 --> 00:32:16,060
+Type I عشان إيه نادرًا ماء يصير كيتو أكسيدوزيز في
+
+410
+00:32:16,060 --> 00:32:19,820
+اللواء المرضى اللواء الـ Type II إلا إذا كانت ..
+
+411
+00:32:19,820 --> 00:32:23,080
+احنا بنحكي على مراحل متأخرة وصار فيه عندي ديتر
+
+412
+00:32:23,080 --> 00:32:26,940
+إيريشن بشكل كبير لـ Beta cells وصار فيه انخفار
+
+413
+00:32:26,940 --> 00:32:33,060
+ممكن بشكل كبير للإنسولين تمام، بيبين هذا المريض هي
+
+414
+00:32:38,140 --> 00:32:40,780
+يبقى .. لأن مافيش أنه كيتون bodies وفي أنه ارتفاع
+
+415
+00:32:40,780 --> 00:32:44,380
+طبعا شكل كبير بالسُكَر This one occurs in patients
+
+416
+00:32:44,380 --> 00:32:49,040
+with type 2 diabetes mellitus وعادة المرضى الـ
+
+417
+00:32:49,040 --> 00:32:51,580
+type 2 diabetes mellitus يعني ممكن يصابوا بهذه
+
+418
+00:32:51,580 --> 00:32:57,940
+الحالة ك acute complication فيه اللي هو حالات ال
+
+419
+00:32:57,940 --> 00:33:02,760
+.. ال severe illness تمام؟ يعني إذا كان صار فيه
+
+420
+00:33:02,760 --> 00:33:08,600
+مرض زي ما انتوا عارفينهي الـ stress hormones وهي
+
+421
+00:33:08,600 --> 00:33:14,680
+بعض الهرمونات تعتبر hyperglycemic agents وبالتالي
+
+422
+00:33:14,680 --> 00:33:19,240
+ممكن ترفع مستوى السكر بشكل كبير تؤدي إلى الـ non
+
+423
+00:33:19,240 --> 00:33:23,860
+-ketotic hyperglycemia أو الـ hyperosmolar non
+
+424
+00:33:23,860 --> 00:33:24,300
+-ketotic
+
+425
+00:33:28,290 --> 00:33:31,930
+هؤلاء المريضين يحافظون على الإنسولين لتحفة
+
+426
+00:33:31,930 --> 00:33:37,510
+كيتوجينيس لكنه ليس كافيا لتحفة الـHyperglycemia
+
+427
+00:33:37,510 --> 00:33:41,350
+تمام؟ لأن وجود الإنسولين زي ما قلنا بيمنع اللي
+
+428
+00:33:41,350 --> 00:33:46,010
+يحصل في عنا اللي هو الـ Ketogenesis طيب الإعلاج
+
+429
+00:33:46,010 --> 00:33:50,270
+هدول المرضى بـ Placement of Fluid and Electrolyte
+
+430
+00:33:50,270 --> 00:33:56,140
+Loss و بإنسولين Infusion لتحفة الـ Glucoseيبعطوهم
+
+431
+00:33:56,140 --> 00:33:58,420
+انسولين عشان يلزموا الجلوكوز هدول عندهم
+
+432
+00:33:58,420 --> 00:34:03,860
+dehydration بيبعطوهم الوثوائل ليه اللي هو إرجاع ال
+
+433
+00:34:03,860 --> 00:34:08,420
+blood value إلى الطبيعي once the acute episode is
+
+434
+00:34:08,420 --> 00:34:13,100
+over انسولين is unlikely to be needed بس تخلص
+
+435
+00:34:13,100 --> 00:34:17,040
+المشكلة يعني ممكن نرجع المريض للعلاج السابق اللي
+
+436
+00:34:17,040 --> 00:34:21,320
+كان ياخده و بوقفه الانسولين زكاه ماكانش بياخد
+
+437
+00:34:21,320 --> 00:34:27,250
+انسولينطيب لما سأله المريض هاد يعني ماشيفي إيش
+
+438
+00:34:27,250 --> 00:34:32,270
+المشكلة he reported having experienced increasing
+
+439
+00:34:32,270 --> 00:34:35,530
+thirst and poliurea و هذه الفترة الصالة هي يعني
+
+440
+00:34:35,530 --> 00:34:39,110
+كمان in several weeks يبقى الظاهر كان عنده
+
+441
+00:34:39,110 --> 00:34:45,910
+الجلوكوز مرتفع و لأنه فيه urination و فيه thirst،
+
+442
+00:34:45,910 --> 00:34:51,870
+تمام؟ فهذا بعد ما يشرب ميه، إيش كان يشرب؟ كان يشرب
+
+443
+00:34:51,870 --> 00:34:58,850
+لمناطقفيها طبعا نسبة سكر كبير طبعا فهو بياخد ميه و
+
+444
+00:34:58,850 --> 00:35:03,670
+بياخد ايش بزيد الطين بلا بياخد كمان سكر اللي هو
+
+445
+00:35:03,670 --> 00:35:08,250
+أصلا عنده مرتفع لغاية ما انتهى العمر عنده بارتفاع
+
+446
+00:35:08,250 --> 00:35:11,910
+بشكل كبير و ب ال dehydration و ارتفاع بالأزمة
+
+447
+00:35:11,910 --> 00:35:15,570
+الليلية زي ما شوفنا طيب الحالة الأخيرة
+
+448
+00:35:26,540 --> 00:35:30,980
+A 45-year-old woman who was unable to feed, wash
+
+449
+00:35:30,980 --> 00:35:34,840
+or dress herself because of severe multiple
+
+450
+00:35:34,840 --> 00:35:39,020
+sclerosis المعنى بيجي في عندها multiple sclerosis
+
+451
+00:35:39,020 --> 00:35:42,420
+اللي هو اتصلوا بالمتعدد فيه مشكلة عند دول المعروف
+
+452
+00:35:42,420 --> 00:35:46,320
+بيكون طبعا بيه اللي هو المياه اللي ينشيه وبالتالي
+
+453
+00:35:46,320 --> 00:35:54,060
+في مشكلة عندهم بيه ال .. طبعا ال nerve signalواللي
+
+454
+00:35:54,060 --> 00:35:59,440
+هو التوصيل اللي هو إشارات العصبية وهذا طبعا يعني
+
+455
+00:35:59,440 --> 00:36:04,040
+فيه إله complications عديدة يعني بتأثر على كل
+
+456
+00:36:04,040 --> 00:36:11,740
+نواحي الحياة عندهم ماشي أكل حركة على كل إشي طيب و
+
+457
+00:36:11,740 --> 00:36:14,780
+هذه المريضة اللي عمرها 45 سنة عندها multiple
+
+458
+00:36:14,780 --> 00:36:20,610
+sclerosisوكان في CV multiple sclerosis وبالتالي هي
+
+459
+00:36:20,610 --> 00:36:24,650
+لا هي جادة تاكل ولا جادة تلبس ولا جادة تتحمم ولا
+
+460
+00:36:24,650 --> 00:36:29,470
+جادة تعمل أي إشي وكانت موجودة فعليا في nursing
+
+461
+00:36:29,470 --> 00:36:32,730
+home يعني في دار للريعاية وهم اللي كانوا باهتموا
+
+462
+00:36:32,730 --> 00:36:39,750
+فيها about six hours after a visit by relatives it
+
+463
+00:36:39,750 --> 00:36:44,850
+was found that she could not be roused يبقى ضرورة
+
+464
+00:36:44,850 --> 00:36:48,600
+أقربهاكان في زيارة الأقل بقى و بعد ست ساعات من
+
+465
+00:36:48,600 --> 00:36:54,640
+انتهاء الزيارة اجلغوها هي كانت مش مصحصة حقيقية بعد
+
+466
+00:36:54,640 --> 00:36:58,920
+ست
+
+467
+00:36:58,920 --> 00:37:04,160
+ساعات مرادروا المكان on admission to a hospital
+
+468
+00:37:04,160 --> 00:37:08,900
+she was found to be extremely hypoglycemic و هذا
+
+469
+00:37:08,900 --> 00:37:13,080
+السبب ان هي زي ايش في نقص شديد بالسكر و glucose
+
+470
+00:37:13,080 --> 00:37:16,870
+اربعة و تلاتين milligram per deciliterتعرفين أقل
+
+471
+00:37:16,870 --> 00:37:20,970
+من الخمسين اللي هو الشخص يدخل في hypoglycemia
+
+472
+00:37:20,970 --> 00:37:23,570
+وطبعا أه يعني هذه تعتبر life threatening condition
+
+473
+00:37:23,570 --> 00:37:26,950
+يعني ممكن يدخل في كومة و ممكن هذه تؤدي إلى الوفاء
+
+474
+00:37:26,950 --> 00:37:34,070
+إذا ما صارش فيه يعني علاج بشكل عاجل طيب required
+
+475
+00:37:34,070 --> 00:37:36,610
+repeated intravenous infusion of glucose مزال في
+
+476
+00:37:36,610 --> 00:37:41,210
+hypoglycemia بغض النظر عن السبب المفروض أطول ينعطى
+
+477
+00:37:41,210 --> 00:37:42,590
+ال patient glucose
+
+478
+00:37:45,510 --> 00:37:50,330
+2 من 2 بلازمة بلوكوز over the next 12 to 24 hours
+
+479
+00:37:50,330 --> 00:37:55,170
+a sample of blood taken on admission was restored
+
+480
+00:37:55,170 --> 00:37:58,250
+and subsequently analyzed for insulin and C
+
+481
+00:37:58,250 --> 00:38:02,770
+-peptide بياخدوا عينة و تحسوا باليعني الدم ال
+
+482
+00:38:02,770 --> 00:38:07,150
+result يعني بياخدوا عينة يعني ممكن لاحقا يشكوا أنه
+
+483
+00:38:07,150 --> 00:38:10,670
+في إشي معين في الدم وبالتالي العينة بتكون موجودة و
+
+484
+00:38:10,670 --> 00:38:15,720
+ممكن يفحصوهاتمام يبقى من الفحصات اللي عملوها عملوا
+
+485
+00:38:15,720 --> 00:38:17,680
+انسولين وعملوا C-peptide result were
+
+486
+00:38:17,680 --> 00:38:22,440
+inappropriately raised كان في عندنا ارتفاع في
+
+487
+00:38:22,440 --> 00:38:28,660
+الانسولين وفي ال C-peptide وهذا اللي هو السبب ان
+
+488
+00:38:28,660 --> 00:38:33,240
+في عندنا hypoglycemia تمام الارتفاع بالانسولين
+
+489
+00:38:33,240 --> 00:38:39,110
+تمام اكيد ممكن يقدي الىاللي هو hypoglycemia وهذا
+
+490
+00:38:39,110 --> 00:38:44,850
+اللي بيصير يعني في عندنا يعني بعد مرضى السكر مثلا
+
+491
+00:38:44,850 --> 00:38:49,910
+اللي بياخدوا insulin تمام ممكن يصير في عندهم
+
+492
+00:38:49,910 --> 00:38:52,870
+hypoglycemia طبعا السبب ممكن يكون أنه أخد جرعة
+
+493
+00:38:52,870 --> 00:38:58,870
+زايدة أخد الجرعة ماأكلش أخد الجرعة ماأكلش الفطور
+
+494
+00:38:58,870 --> 00:39:01,610
+اللي عادة بياكله مثلا اللي في كمية معينة من ال
+
+495
+00:39:01,610 --> 00:39:05,590
+carbohydrates ممكن يكون أخد الجرعة وبدأ المجهود
+
+496
+00:39:05,590 --> 00:39:10,790
+أكبرتمام؟ يعني إيه؟ صار فيه مجهود أكبر عادة بتمشي
+
+497
+00:39:10,790 --> 00:39:14,110
+يعني بذله؟ هذه ممكن كلها تؤدي إلى اللي هو
+
+498
+00:39:14,110 --> 00:39:20,190
+hypoglycemia طيب over the next few days repeated
+
+499
+00:39:20,190 --> 00:39:24,650
+overnight fasts failed to induce further
+
+500
+00:39:24,650 --> 00:39:26,090
+hypoglycemia
+
+501
+00:39:27,790 --> 00:39:32,890
+يبقى يعني لأنه هان بشكه ما زال في عنا زيادة في ال
+
+502
+00:39:32,890 --> 00:39:35,810
+insulin و في عنا زيادة في ال C-peptide يبقى علاته
+
+503
+00:39:35,810 --> 00:39:41,330
+ال insulin إيش داخلي مظبوط ما زال في C-peptide
+
+504
+00:39:41,330 --> 00:39:46,730
+يبقى ال insulin إيش داخلي و هي بتاخدش insulin يعني
+
+505
+00:39:46,730 --> 00:39:51,380
+يبقى بشكه أنه ممكن يكون في إيش Encelanomaتمام؟ في
+
+506
+00:39:51,380 --> 00:39:53,700
+عندنا ممكن cancer في ال beta cells وفي إنتاج
+
+507
+00:39:53,700 --> 00:39:59,300
+بكميات كبيرة للإنسلين الأن هدول يعني عشان يشوفوا
+
+508
+00:39:59,300 --> 00:40:05,420
+أنه فعلا أنه زيادة في ال insulin بسبب ال insulin
+
+509
+00:40:05,420 --> 00:40:10,140
+load ما بيعمل overnight لوا fast والمفروض أن يحصل
+
+510
+00:40:10,140 --> 00:40:14,320
+فيه hypoglycemia لو فعلا في لوا insulin load
+
+511
+00:40:14,320 --> 00:40:20,180
+eventually after a prolonged fastفي أربع أيام
+
+512
+00:40:20,180 --> 00:40:27,360
+الجلوكوز اتفق إلى 45 يعني في اليوم الرابع نزل
+
+513
+00:40:27,360 --> 00:40:33,520
+لجلوكوز ل 45 في وقت ما انسولين وC-Peptide كانوا
+
+514
+00:40:33,520 --> 00:40:39,860
+غير ملاحظين يعني ماكنش في عندنا الارتفاع في
+
+515
+00:40:39,860 --> 00:40:47,400
+انسولين زي المرة الأولى نتيجة الدراسة
+
+516
+00:40:51,830 --> 00:40:54,530
+هيبوغلايسيمية ارتفاع في الإنسلين وارتفاع في الـ C
+
+517
+00:40:54,530 --> 00:40:59,190
+-Peptide يدوم كلهم يشيروا إلى إنه في عنده زيادة في
+
+518
+00:40:59,190 --> 00:41:04,630
+إفراز الإنسلين وبيتاليه كل كيلون انسلين طيب هل هو
+
+519
+00:41:04,630 --> 00:41:07,530
+ذرع تثبت صعوبة تدفعك إلى أكتر حلقة من
+
+520
+00:41:07,530 --> 00:41:10,910
+الهيبوغلايسيمية؟ هذا ما قلنا إن أكتر الأشخاص مع
+
+521
+00:41:10,910 --> 00:41:15,050
+انسلنومة سيكونوا هيبوغلايسيميك على أحد أو أكتر
+
+522
+00:41:15,050 --> 00:41:21,290
+حلقات بعد ثلاث فاصلات عامةلو صار فيه صوم overnight
+
+523
+00:41:21,290 --> 00:41:24,550
+فاصلة لمدة تلت أيام إلا يصير في عندهم hypoglycemia
+
+524
+00:41:24,550 --> 00:41:28,990
+مرة تانية لكن هذا المريضة صار في overnight فاصلة
+
+525
+00:41:28,990 --> 00:41:32,590
+لمدة تلت أيام لكن ماصارش فيه hypoglycemia و باليوم
+
+526
+00:41:32,590 --> 00:41:39,750
+الرابع صار فيه انخفاض و نزل لـ45 و even prolonged
+
+527
+00:41:39,750 --> 00:41:43,550
+fast failed to induce true hypoglycemia and at
+
+528
+00:41:43,550 --> 00:41:47,510
+that time insulin level was appropriately lowلم
+
+529
+00:41:47,510 --> 00:41:51,210
+يكنش فيه إرتفاع Review of her history revealed no
+
+530
+00:41:51,210 --> 00:41:56,490
+suggestion of previous hypoglycemic episodes تمام؟
+
+531
+00:41:56,490 --> 00:42:01,410
+كمان ما قمرش يعني صار عندها hypoglycemia سابقا
+
+532
+00:42:01,410 --> 00:42:04,790
+Clinical staff were accordingly forced to
+
+533
+00:42:04,790 --> 00:42:08,630
+reconsider the initial diagnosis يعني بعد هذه
+
+534
+00:42:08,630 --> 00:42:13,630
+الفحصات اللي قملوها يرجعوا جالوا باحتمال عندها مرة
+
+535
+00:42:13,630 --> 00:42:14,710
+تانية اللي هو Enceloma
+
+536
+00:42:23,340 --> 00:42:28,380
+العينة اللي احتفظوا فيها رجوا بعتوا هشوفوا and was
+
+537
+00:42:28,380 --> 00:42:30,660
+found to contain high concentrations of the oral
+
+538
+00:42:30,660 --> 00:42:37,340
+hypoglycemic drugs Chloropropamide و Eglipin
+
+539
+00:42:37,340 --> 00:42:43,720
+Clamide وهده ال drugs هم عبارة عن sulfonylurea
+
+540
+00:42:45,250 --> 00:42:50,670
+الأدوية التي قمنا بتعملها تزيد من إفراز
+
+541
+00:42:50,670 --> 00:42:54,850
+الإنسفلينة، مجبور؟ مجبور أن الpatient اللي كان فيه
+
+542
+00:42:54,850 --> 00:42:58,230
+اندولبودي يعطوه اللي هو الـ Sulfonylurea عشان
+
+543
+00:42:58,230 --> 00:43:01,850
+يزيدوا فقط إيش من إفراز اللي هو الإنسفلينة اللي
+
+544
+00:43:01,850 --> 00:43:06,390
+عنده طيب، these drugs Sulfonylurea which act by
+
+545
+00:43:06,390 --> 00:43:08,890
+enhancing pancreatic insulin secretion in response
+
+546
+00:43:08,890 --> 00:43:16,640
+to glucoseهدوم النوعين have long half-lives، الـ
+
+547
+00:43:16,640 --> 00:43:21,000
+half-life بتاعتهم أيش كمان؟ طويلة، making
+
+548
+00:43:21,000 --> 00:43:25,440
+hypoglycemia an occasional problem even when used
+
+549
+00:43:25,440 --> 00:43:28,580
+therapeutically in patients with diabetes
+
+550
+00:43:33,600 --> 00:43:36,000
+طيب، ماذا يجب أن تحصل على هذه الأدوية؟ ممكن أن
+
+551
+00:43:36,000 --> 00:43:39,160
+تحصل على أو تأخذ هذه الأدوية؟ لأننا قلنا لا جادرة
+
+552
+00:43:39,160 --> 00:43:43,120
+تأكل ولا جادرة تشرب ولا جادرة تعمل إشي طب كيف هذه
+
+553
+00:43:43,120 --> 00:43:49,020
+الأدوية ما زال الممرضين ما أعطوهاش؟ كيف وصلت ودخلت
+
+554
+00:43:49,020 --> 00:43:57,920
+جسمها؟ يبقى صار إيش كأنه محاولة قتل طيب، it was
+
+555
+00:43:57,920 --> 00:44:00,860
+likely that a relative distressed by hair
+
+556
+00:44:00,860 --> 00:44:05,900
+conditionمن الناس الأقارب اللي جذبوها حزنوا عليها
+
+557
+00:44:05,900 --> 00:44:14,060
+شفوها بالحالة هذه فظاهر واحد إيش بده يعني ينهي
+
+558
+00:44:14,060 --> 00:44:18,700
+حياته طيب ال police were informed that it was felt
+
+559
+00:44:18,700 --> 00:44:22,040
+that there was insufficient evidence to proceed
+
+560
+00:44:22,040 --> 00:44:27,400
+الفرق يعني صار في إغلاق القضية لعدم كفاية الأدلة
+
+561
+00:44:27,400 --> 00:44:31,720
+زي ما بيحكوا يعطيكوا ألف عافية
+
diff --git a/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/sOPZ3-OZ39g.srt b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/sOPZ3-OZ39g.srt
new file mode 100644
index 0000000000000000000000000000000000000000..f6cadb2685b19c64d51ea0e8b8ad1186641dfdc7
--- /dev/null
+++ b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/sOPZ3-OZ39g.srt
@@ -0,0 +1,615 @@
+1
+00:00:02,460 --> 00:00:06,760
+maturity onset diabetes of the young أو مودي
+
+2
+00:00:06,760 --> 00:00:11,360
+initial success in the search for جينات ديابات و
+
+3
+00:00:11,360 --> 00:00:14,520
+was seen in maturity onset diabetes of the young
+
+4
+00:00:14,520 --> 00:00:20,400
+يعني أول نجاح في ربط المشكلات اللي بتصير في بعض الجينات
+
+5
+00:00:20,400 --> 00:00:26,080
+و الـ diabetes المودي عبارة عن rare group of
+
+6
+00:00:26,080 --> 00:00:30,220
+disorders characterized by non-ketotic diabetes
+
+7
+00:00:33,710 --> 00:00:37,030
+الشيء اللي يشبه الـ Type 2 diabetes mellitus هو أن
+
+8
+00:00:37,030 --> 00:00:43,470
+الـ مودي يظهر في عمر صغير وعشان هيك بيصير في بعض
+
+9
+00:00:43,470 --> 00:00:46,450
+الحالات اللي هي الـ مودي بيتم تشخيصها على إنها Type 2
+
+10
+00:00:46,450 --> 00:00:52,670
+diabetes mellitus لكن الفرق أن الـ مودي بتصير at a
+
+11
+00:00:52,670 --> 00:00:58,610
+younger age اللي هو أقل من 25 سنة لكن الآن مع الـ
+
+12
+00:00:58,610 --> 00:01:03,570
+.. برضه الإصابة بالـ type 2 diabetes mellitus برضه
+
+13
+00:01:03,570 --> 00:01:07,070
+at a younger age برضه هان ممكن يصير في عندنا يعني
+
+14
+00:01:07,070 --> 00:01:09,950
+مشكلة و لبس في التشخيص
+
+15
+00:01:12,470 --> 00:01:18,230
+يبقى مرضى شباب، غير بدناء مصابين بالسكري الذين
+
+16
+00:01:18,230 --> 00:01:22,990
+لديهم تاريخ عائلي للإصابة بالسكري يبقى كمان بيكون
+
+17
+00:01:22,990 --> 00:01:27,090
+فيه يعني تاريخ عائلي للإصابة بالسكري، Younger
+
+18
+00:01:27,090 --> 00:01:31,850
+age و non-obese A clinical spectrum of مودي is
+
+19
+00:01:31,850 --> 00:01:36,550
+broad ranging from asymptomatic hyperglycemia to
+
+20
+00:01:36,550 --> 00:01:41,290
+an acute presentation يبقى ممكن الناس اللي عندهم
+
+21
+00:01:41,290 --> 00:01:46,230
+مودي يعني يعيشوا حياة طبيعية بدون ما يكون في عندهم أي
+
+22
+00:01:46,230 --> 00:01:52,630
+مشكلة يعني يكون فقط أن في ارتفاع اللي هو يعني
+
+23
+00:01:52,630 --> 00:01:58,650
+بسيط في الـ glucose هؤلاء المرضى يعني إحنا ما فيش
+
+24
+00:01:58,650 --> 00:02:03,190
+أعراض وبالتالي ممكن يتم اكتشافهم صدفة يعني شخص
+
+25
+00:02:03,190 --> 00:02:08,210
+بيدروح ممكن يعمل بعض الفحوصات لسبب أو لآخر ويتم
+
+26
+00:02:08,210 --> 00:02:13,930
+الاكتشاف أنه في عنده hyperglycemia. Thirteen genes
+
+27
+00:02:13,930 --> 00:02:16,630
+are associated with this disorder
+
+28
+00:02:19,950 --> 00:02:23,990
+طبعا في الـ .. اللي هو بناء على المشكلة في أن أنواع
+
+29
+00:02:23,990 --> 00:02:29,630
+مختلفة من المودي  الـ مودي two result from mutations
+
+30
+00:02:29,630 --> 00:02:34,570
+in the gene that encodes a glucokinase وبالتالي
+
+31
+00:02:34,570 --> 00:02:38,450
+هذا بيؤدي إلى partial deficiency of insulin
+
+32
+00:02:38,450 --> 00:02:43,370
+secretion. بيبصير فينا نقص في إفراز الإنسولين وهذا
+
+33
+00:02:43,370 --> 00:02:48,090
+بيكون في المودي 2 طبعا هذا بيكون سبب ارتفاع
+
+34
+00:02:48,090 --> 00:02:55,060
+الجلوكوز في الدم. الأنواع الأخرى من المودي caused by
+
+35
+00:02:55,060 --> 00:02:58,300
+mutations in the genes that encode transcription
+
+36
+00:02:58,300 --> 00:03:05,680
+factors. يبقى المشكلة في الجينات اللي بتؤدي إلى
+
+37
+00:03:05,680 --> 00:03:09,280
+تكوين اللي هو الـ transcription factors واللي
+
+38
+00:03:09,280 --> 00:03:10,880
+مسؤولة عن
+
+39
+00:03:13,180 --> 00:03:16,980
+الـ regulation لـ expression of different genes in
+
+40
+00:03:16,980 --> 00:03:21,340
+the pancreatic beta cells. وما زال لأن المشكلة في
+
+41
+00:03:21,340 --> 00:03:24,600
+الـ expression للجينة في خلايا بيتا البنكرياس
+
+42
+00:03:24,600 --> 00:03:30,580
+يبقى هذا هيؤدي إلى impaired insulin synthesis أو
+
+43
+00:03:30,580 --> 00:03:36,320
+secretion أو ممكن يؤدي إلى reduced beta cell mass
+
+44
+00:03:38,650 --> 00:03:41,830
+مودي mutations have substitution. بقى المشكلات اللي
+
+45
+00:03:41,830 --> 00:03:44,630
+أو الطفرات اللي ممكن تكون موجودة في الأنواع
+
+46
+00:03:44,630 --> 00:03:49,590
+المختلفة substitution, deletion أو insertion of
+
+47
+00:03:49,590 --> 00:03:54,150
+nucleotides in the coding region of the genes. طبعا
+
+48
+00:03:54,150 --> 00:04:01,090
+ممكن الكشف عن الطفرات المختلفة من خلال الـ PCR
+
+49
+00:04:03,610 --> 00:04:06,450
+عندنا الـ Oral Glucose Reliance Test و الـ Islet
+
+50
+00:04:06,450 --> 00:04:10,770
+Cell Antibodies و الـ C-Peptide. هدول ممكن يساعدوا
+
+51
+00:04:10,770 --> 00:04:15,930
+على التفرقة بين المودي و الـ Type 1 أو
+
+52
+00:04:15,930 --> 00:04:21,170
+الـ Type 2 Diabetes لكن الاختبار الجيني مطلوب
+
+53
+00:04:21,170 --> 00:04:28,860
+لتأكيد تشخيص المودي.  نقطة أخرى،  الـ
+
+54
+00:04:28,860 --> 00:04:33,480
+معايير تشخيص مرض السكري طبعا
+
+55
+00:04:33,480 --> 00:04:37,740
+التشخيص يتم باستخدام الفحوصات المختلفة أو
+
+56
+00:04:37,740 --> 00:04:40,780
+أي من الفحوصات اللي ممكن نستخدمها، منها الـ
+
+57
+00:04:40,780 --> 00:04:47,560
+Hemoglobin A1c.  الـ cut-off point لو 6.5
+
+58
+00:04:47,560 --> 00:04:55,380
+% أو أكثر، و 6.5% أو أكثر معناته بنقول أن
+
+59
+00:04:55,380 --> 00:04:58,640
+الشخص عنده مرض السكري.  test should be
+
+60
+00:04:58,640 --> 00:05:02,300
+performed in a laboratory using a method that is
+
+61
+00:05:02,300 --> 00:05:07,780
+NGSP certified. يبقى عندنا فيه طرق عديدة لفحص الـ
+
+62
+00:05:07,780 --> 00:05:12,680
+Hemoglobin A1C لكن إذا كنا نستخدم فحص الـ
+
+63
+00:05:12,680 --> 00:05:18,870
+Hemoglobin A1C لتشخيص السكري لابد أنه
+
+64
+00:05:18,870 --> 00:05:24,270
+يكون فحص معياري والفحص المعياري هذا
+
+65
+00:05:24,270 --> 00:05:30,590
+يعني بده يكون حاصل على شهادة من جهة تسمى الـ
+
+66
+00:05:30,590 --> 00:05:35,510
+NGSP (National Glycohemoglobin Standardization
+
+67
+00:05:35,510 --> 00:05:40,050
+Program). تمام، هي مش أي  طقم موجود في السوق ممكن
+
+68
+00:05:40,050 --> 00:05:45,310
+نستخدمه، تمام، لازم تكون اللي هي معتمدة من الـ
+
+69
+00:05:45,310 --> 00:05:46,330
+NGSP
+
+70
+00:05:48,500 --> 00:05:51,720
+A point-of-care assay should not be used for
+
+71
+00:05:51,720 --> 00:05:57,660
+diagnosis. اللي هي الـ point-of-care assay زي مثلا
+
+72
+00:05:57,660 --> 00:06:02,780
+اللي هو الـ strips اللي بتستخدم في بعض الفحوصات هذه
+
+73
+00:06:02,780 --> 00:06:08,260
+في منها اللي هي مجلوب A و C لكن هذه مش لازم تستخدم
+
+74
+00:06:08,260 --> 00:06:13,460
+للـ diagnosis أيضا. من الفحوصات اللي ممكن نستخدمها
+
+75
+00:06:13,460 --> 00:06:18,280
+الـ fasting plasma glucose، وإيه عندنا؟ اللي هو الـ
+
+76
+00:06:18,280 --> 00:06:22,740
+concentration إذا كان 126 milligram per deciliter
+
+77
+00:06:22,740 --> 00:06:28,820
+أو أعلى معناته الشخص ممكن نقول إنه عنده مرض السكري
+
+78
+00:06:28,820 --> 00:06:31,540
+mellitus. Fasting is defined as non-calorie intake
+
+79
+00:06:31,540 --> 00:06:34,460
+for at least eight hours. طبعا لازم يكون الشخص صائم
+
+80
+00:06:34,460 --> 00:06:41,440
+على الأقل ثمان ساعات. أعراض
+
+81
+00:06:41,440 --> 00:06:47,360
+of hyperglycemia and casual plasma glucose of two
+
+82
+00:06:47,360 --> 00:06:52,780
+hundred milligram per deciliter or greater. اللي
+
+83
+00:06:52,780 --> 00:06:57,980
+هو الـ .. الـ casual plasma glucose اللي هو فحص
+
+84
+00:06:57,980 --> 00:07:03,330
+يعني الـ glucose في أي وقت خلال اليوم without
+
+85
+00:07:03,330 --> 00:07:07,530
+regard to time since the last meal، اللي هو random
+
+86
+00:07:07,530 --> 00:07:11,450
+يعني، يعني casual أو random blood glucose، لأن كان
+
+87
+00:07:11,450 --> 00:07:17,450
+في أعراض موجودة لارتفاع مستوى السكر في الدم، مع
+
+88
+00:07:17,450 --> 00:07:22,540
+casual plasma glucose أو random plasma glucose. الـ
+
+89
+00:07:22,540 --> 00:07:26,160
+Concentration 200 mg per deciliter أو أكثر هي برضه
+
+90
+00:07:26,160 --> 00:07:29,880
+هذا ممكن  وقتين تشخيصه على أنه عنده type 2
+
+91
+00:07:29,880 --> 00:07:32,720
+على أنه عنده مرض السكري. the classic
+
+92
+00:07:32,720 --> 00:07:35,220
+symptoms of hyperglycemia include polyuria،
+
+93
+00:07:35,220 --> 00:07:42,740
+polydipsia، and unexplained weight loss. أيضا فحص
+
+94
+00:07:42,740 --> 00:07:46,040
+آخر اللي هو الـ Oral Glucose Tolerance Test
+
+95
+00:07:46,040 --> 00:07:52,880
+باستخدام هذا الفحص إذا كان بعد ساعتين من إعطاء
+
+96
+00:07:52,880 --> 00:08:00,080
+الجرعة من الجلوكوز 75 جرام، بعد ساعتين إذا طلعت أن
+
+97
+00:08:00,080 --> 00:08:03,380
+الـ concentration لـ plasma glucose أكتر من 200
+
+98
+00:08:03,380 --> 00:08:08,320
+ميلي جرام per deciliter، أي بمعناته برضه هذا الشخص
+
+99
+00:08:08,320 --> 00:08:11,920
+يمكن تشخيصه على أنه مصاب بمرض السكري.
+
+100
+00:08:15,840 --> 00:08:20,180
+يبقى إذا كان عندنا يعني الأمر مش واضح أو في لبس
+
+101
+00:08:20,180 --> 00:08:25,840
+أو عندنا ارتفاع السكر في الدم مش واضح بشكل يعني كبير
+
+102
+00:08:25,840 --> 00:08:30,520
+يبقى هذه المعايير يجب تأكيدها عن طريق
+
+103
+00:08:30,520 --> 00:08:34,340
+إعادة نفس الاختبار في يوم مختلف. لابد من
+
+104
+00:08:34,340 --> 00:08:39,720
+إعادة الفحص مرة أخرى في اليوم التالي
+
+105
+00:08:39,720 --> 00:08:47,390
+لتأكيد أو نفي الإصابة بمرض السكري. بالنسبة
+
+106
+00:08:47,390 --> 00:08:50,690
+للمضاعفات، طبعا قلنا إنه في مضاعفات
+
+107
+00:08:50,690 --> 00:08:54,530
+عديدة بتكون يعني مصاحبة للإصابة بمرض السكري
+
+108
+00:08:54,530 --> 00:09:01,190
+والناتجة عن الارتفاع المستمر لجلوكوز الدم
+
+109
+00:09:01,190 --> 00:09:04,130
+patients with both type 1 and type 2 diabetes are
+
+110
+00:09:04,130 --> 00:09:07,230
+at high risk for the development of chronic
+
+111
+00:09:07,230 --> 00:09:10,930
+complications. ومن هذه المضاعفات قلنا فيها
+
+112
+00:09:10,930 --> 00:09:15,570
+أن المضاعفات الميكرووعائية، والتي قد تؤدي
+
+113
+00:09:15,570 --> 00:09:20,030
+إلى اعتلال الشبكية، اعتلال الكلية أو اعتلال الأعصاب، وعندنا الـ
+
+114
+00:09:20,030 --> 00:09:24,310
+مضاعفات الماكرووعائية اللي هي ممكن تؤدي إلى
+
+115
+00:09:24,310 --> 00:09:28,930
+تصلب الشرايين وأمراض القلب والأوعية الدموية
+
+116
+00:09:31,990 --> 00:09:39,710
+بما يتعلق بالآليات الجزيئية المسؤولة عن
+
+117
+00:09:39,710 --> 00:09:44,330
+المضاعفات المختلفة الناتجة عن ارتفاع الجلوكوز
+
+118
+00:09:44,330 --> 00:09:50,230
+في الدم، أن العديد من الفرضيات وقد تم تفضيلها
+
+119
+00:09:50,230 --> 00:09:54,050
+لتفسير كيف يسبب ارتفاع السكر في الدم  ارتفاع السكر في الدم
+
+120
+00:09:54,050 --> 00:09:54,290
+ارتفاع السكر في الدم ارتفاع السكر في الدم ارتفاع السكر في الدم
+
+121
+00:09:54,290 --> 00:09:54,970
+ارتفاع السكر في الدم ارتفاع السكر في الدم ارتفاع السكر في الدم
+
+122
+00:09:54,970 --> 00:09:58,650
+ارتفاع السكر في الدم ارتفاع السكر في الدم ارتفاع السكر في الدم
+
+123
+00:09:58,650 --> 00:10:03,510
+ارتفاع السكر في الدم ارتفاع السكر في الدم ارتفاع السكر في الدم
+
+124
+00:10:03,510 --> 00:10:04,510
+ارتفاع السكر في الدم ارتفاع السكر في الدم ارتفاع السكر في الدم
+
+125
+00:10:04,510 --> 00:10:04,550
+ارتفاع السكر في الدم ارتفاع السكر في الدم ارتفاع السكر في الدم
+
+126
+00:10:04,550 --> 00:10:10,690
+ارتفاع السكر في الدم ارتفاع السكر في الدم ارتفاع السكر في الدم، اللي هو
+
+127
+00:10:10,690 --> 00:10:14,410
+زي الـ .. اللي هو الـ Hemoglobin A1C أو زي اللي هو
+
+128
+00:10:14,410 --> 00:10:20,730
+الـ .. الـ Glucated albumin. تفعيل بروتين
+
+129
+00:10:20,730 --> 00:10:27,090
+كيناز C وتفعيل بروتين كيناز C  ممكن يزيد من
+
+130
+00:10:27,090 --> 00:10:31,210
+الـ oxidative stress، production of super oxide
+
+131
+00:10:31,210 --> 00:10:35,650
+and other reactive oxygen species. اللي هو عن طريق
+
+132
+00:10:35,650 --> 00:10:39,130
+سلسلة نقل الإلكترون الميتوكوندريا. برضه أن
+
+133
+00:10:39,130 --> 00:10:43,370
+الـ endoplasmic reticulum stress، increased
+
+134
+00:10:43,370 --> 00:10:48,850
+hexosamine pathway flux، و تفعيل
+
+135
+00:10:48,850 --> 00:10:52,270
+sarcomergic-II domain containing phosphatase-I، الـ
+
+136
+00:10:52,270 --> 00:11:02,890
+SHP-I. الآن كل هذه الآليات المرتبطة
+
+137
+00:11:02,890 --> 00:11:10,240
+ببعضها هو الإنتاج المفرط لـ Super Oxide. يبقى
+
+138
+00:11:10,240 --> 00:11:16,540
+عندنا المشكلة الأساسية هي زيادة الأنواع الأكسجينية التفاعلية
+
+139
+00:11:16,540 --> 00:11:22,260
+وهذا اللي هو العامل المشترك بين كل
+
+140
+00:11:22,260 --> 00:11:29,660
+الآليات الجزيئية اللي ذكرناها. والعديد من
+
+141
+00:11:29,660 --> 00:11:34,200
+الـ clinical trials are underway using novel
+
+142
+00:11:34,200 --> 00:11:37,580
+therapies specifically directed at the signaling
+
+143
+00:11:37,580 --> 00:11:41,100
+molecules اللي هو زي بروتين كيناز C اللي قلنا
+
+144
+00:11:41,100 --> 00:11:44,720
+يزيد من الـ .. الـ .. الـ oxidative stress أو
+
+145
+00:11:44,720 --> 00:11:50,580
+باستخدام مضادات الأكسدة لمعادلة آثار
+
+146
+00:11:50,580 --> 00:11:54,470
+المؤكسدات، لأنه زي ما قلنا العامل المشترك
+
+147
+00:11:54,470 --> 00:12:00,470
+والمشكلة الناتجة عن كل الآليات هو الـ .. الـ
+
+148
+00:12:00,470 --> 00:12:03,070
+مؤكسدات أو الزيادة في الأنواع الأكسجينية التفاعلية
+
+149
+00:12:03,070 --> 00:12:07,550
+وبالتالي إذا كنا تعاملنا مع الأنواع الأكسجينية التفاعلية
+
+150
+00:12:07,550 --> 00:12:13,970
+وقلّّلناها، يبقى ممكن يعني هذا مستقبلا
+
+151
+00:12:13,970 --> 00:12:16,630
+يعني يكون حلّ
+
+152
+00:12:19,440 --> 00:12:24,400
+أو يعني يكون حلّ للمضاعفات اللي خاصة بـ
+
+153
+00:12:24,400 --> 00:12:32,160
+مرض السكري. هيك بيكون انتهينا من الجزء الأول
+
+154
+00:12:32,160 --> 00:12:36,500
+من محاضرة مرض السكري ويعطيكم ألف عافية
diff --git a/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/sOPZ3-OZ39g_postprocess.srt b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/sOPZ3-OZ39g_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..095a107136d8fe21bc8fcbc0649814d94cda0966
--- /dev/null
+++ b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/sOPZ3-OZ39g_postprocess.srt
@@ -0,0 +1,616 @@
+1
+00:00:02,460 --> 00:00:06,760
+maturity onset diabetes of the young أو مودي
+
+2
+00:00:06,760 --> 00:00:11,360
+initial success in the search for ديابات و genes
+
+3
+00:00:11,360 --> 00:00:14,520
+was seen in maturity onset diabetes of the young
+
+4
+00:00:14,520 --> 00:00:20,400
+يعني أول نجاح في ربط المشكلات اللي بتصير في بعض ال
+
+5
+00:00:20,400 --> 00:00:26,080
+genes و ال diabetes المودي عبارة عن rare group of
+
+6
+00:00:26,080 --> 00:00:30,220
+disorders characterized by non-ketotic diabetes
+
+7
+00:00:33,710 --> 00:00:37,030
+الشيء اللي يشبه الـ Type 2 diabetes mellitus هو أن
+
+8
+00:00:37,030 --> 00:00:43,470
+الموضي يموت في عمر صغير وعشان هيك بيصير في بعض
+
+9
+00:00:43,470 --> 00:00:46,450
+الحالات اللي هي الموضي بيتم تشخيص علي إنها Type 2
+
+10
+00:00:46,450 --> 00:00:52,670
+diabetes mellitusلكن الفرق أن الـ Modi بتصير at a
+
+11
+00:00:52,670 --> 00:00:58,610
+younger age اللي هو أقل من 25 سنة لكن الآن مع ال
+
+12
+00:00:58,610 --> 00:01:03,570
+.. برضه الإصابة بالـ type 2 diabetes mellitus برضه
+
+13
+00:01:03,570 --> 00:01:07,070
+at younger age برضه هان ممكن يصير في عنا يعني
+
+14
+00:01:07,070 --> 00:01:09,950
+مشكلة و لبس فيه التشخيص
+
+15
+00:01:12,470 --> 00:01:18,230
+يبقى young، non-obese patients with diabetes who
+
+16
+00:01:18,230 --> 00:01:22,990
+have a family history of diabetes يبقى كمان بيكون
+
+17
+00:01:22,990 --> 00:01:27,090
+فيه يعني تاريخ للعائلة الإصابة بالديابيتس، younger
+
+18
+00:01:27,090 --> 00:01:31,850
+age و non-obese A clinical spectrum of Maudi is
+
+19
+00:01:31,850 --> 00:01:36,550
+broad ranging from asymptomatic hyperglycemia to
+
+20
+00:01:36,550 --> 00:01:41,290
+an acute presentationيبقى ممكن الناس اللي عندهم
+
+21
+00:01:41,290 --> 00:01:46,230
+موضي يعني يعيش حياة طبيعية بدون ما يكون في عنده أي
+
+22
+00:01:46,230 --> 00:01:52,630
+مشكلة يعني يكون فقط أنه في ارتفاع اللي هو يعني
+
+23
+00:01:52,630 --> 00:01:58,650
+بسيط في ال glucoseهدول المرضى يعني احنا مافيش
+
+24
+00:01:58,650 --> 00:02:03,190
+symptoms وبالتالي ممكن يتم اكتشافهم صدفة يعني شخص
+
+25
+00:02:03,190 --> 00:02:08,210
+بيدروح ممكن يعمل بعض الفحوصات لسبب او لآخر ويتم
+
+26
+00:02:08,210 --> 00:02:13,930
+الاكتشاف انه في عنده hyperglycemia thirteen genes
+
+27
+00:02:13,930 --> 00:02:16,630
+are associated with this disorder
+
+28
+00:02:19,950 --> 00:02:23,990
+طبعا في ال .. اللي هو بناء على المشكلة في أن أنواع
+
+29
+00:02:23,990 --> 00:02:29,630
+مختلفة من المودي المودي tworesult from mutations
+
+30
+00:02:29,630 --> 00:02:34,570
+in the gene that encodes a glucokinase وبالتالي
+
+31
+00:02:34,570 --> 00:02:38,450
+هذا بيؤدي إلى partial deficiency of insulin
+
+32
+00:02:38,450 --> 00:02:43,370
+secretion بيبصير فينا نقص في إفراز الإنسولين وهذا
+
+33
+00:02:43,370 --> 00:02:48,090
+بيكون في المودي 2 طبعا هذا بيكون سبب ارتفاع
+
+34
+00:02:48,090 --> 00:02:55,060
+الجلوكوز في الدمالأنواع الأخرى من الموضي caused by
+
+35
+00:02:55,060 --> 00:02:58,300
+mutations in the genes that encode transcription
+
+36
+00:02:58,300 --> 00:03:05,680
+factors يبقى المشكلة في ال genes اللي بتؤدي إلى
+
+37
+00:03:05,680 --> 00:03:09,280
+تكوين اللي هو ال transcription factors واللي
+
+38
+00:03:09,280 --> 00:03:10,880
+مسئولة عن
+
+39
+00:03:13,180 --> 00:03:16,980
+الـ regulation لـ expression of different genes in
+
+40
+00:03:16,980 --> 00:03:21,340
+the pancreatic beta cells وما زال لأن المشكلة في
+
+41
+00:03:21,340 --> 00:03:24,600
+ال expression لجنس في ال pancreatic beta cells
+
+42
+00:03:24,600 --> 00:03:30,580
+يبقى هذا هيؤدي إلى impaired insulin synthesis أو
+
+43
+00:03:30,580 --> 00:03:36,320
+secretion أو ممكن يؤدي إلى reduced beta cell mass
+
+44
+00:03:38,650 --> 00:03:41,830
+mode mutations have substitution بقى المشكلات اللي
+
+45
+00:03:41,830 --> 00:03:44,630
+أو ال mutations اللي ممكن تكون موجودة في الأنواع
+
+46
+00:03:44,630 --> 00:03:49,590
+المختلفة substitution, deletion أو insertion of
+
+47
+00:03:49,590 --> 00:03:54,150
+nucleotides in the coding region of the genes طبعا
+
+48
+00:03:54,150 --> 00:04:01,090
+ممكن الكشف عن ال mutations المختلفة من خلال ال PCR
+
+49
+00:04:03,610 --> 00:04:06,450
+عنا الـ Orange Glucose Reliance Test و الـ Islet
+
+50
+00:04:06,450 --> 00:04:10,770
+O2 Antibodies و الـ C-Peptide هدول ممكن يساعدوا
+
+51
+00:04:10,770 --> 00:04:15,930
+على الـ differentiation بين المودي و الـ Type 1 أو
+
+52
+00:04:15,930 --> 00:04:21,170
+الـ Type 2 Diabetes لكن الـ genetic test مطلوبة
+
+53
+00:04:21,170 --> 00:04:28,860
+لتأكيد ال diagnosis of موديطيب نقطة أخرى ال
+
+54
+00:04:28,860 --> 00:04:33,480
+criteria for diagnosis of diabetes mellitus طبعا
+
+55
+00:04:33,480 --> 00:04:37,740
+ال diagnosis بتايم باستخدام الفحوصات المختلفة أو
+
+56
+00:04:37,740 --> 00:04:40,780
+أي من الفحوصات اللي ممكن نستخدمها فينا ال
+
+57
+00:04:40,780 --> 00:04:47,560
+hemoglobin A1c ال cut-off point لو ستة و خمسة
+
+58
+00:04:47,560 --> 00:04:55,380
+بالمية or greaterو 6.5% أو أكتر معناته بنقول أن
+
+59
+00:04:55,380 --> 00:04:58,640
+الشخص عنده diabetes mellitus test should be
+
+60
+00:04:58,640 --> 00:05:02,300
+performed in a laboratory using a method that is
+
+61
+00:05:02,300 --> 00:05:07,780
+NGSP certified يبقى عندنا فيه طرق عديدة لفحص ال
+
+62
+00:05:07,780 --> 00:05:12,680
+hemoglobin A1C لكن إذا كنا نستخدم فحص ال
+
+63
+00:05:12,680 --> 00:05:18,870
+hemoglobin A1C لال diagnosisof diabetes لابد إنه
+
+64
+00:05:18,870 --> 00:05:24,270
+يكون standardized test و ال standardized test هذا
+
+65
+00:05:24,270 --> 00:05:30,590
+يعني بدي يكون ماخد certificate من جهة اللي تسمى ال
+
+66
+00:05:30,590 --> 00:05:35,510
+NGSB national glycohemoglobin standardization
+
+67
+00:05:35,510 --> 00:05:40,050
+program تمام، هي مش أي kit موجودة بالسوق ممكن
+
+68
+00:05:40,050 --> 00:05:45,310
+نستخدمها تمام، لازم تكون اللي هي certified من ال
+
+69
+00:05:45,310 --> 00:05:46,330
+NGSB
+
+70
+00:05:48,500 --> 00:05:51,720
+a point of care assay should not be used for
+
+71
+00:05:51,720 --> 00:05:57,660
+diagnoses اللي هي ال point of care assay زي مثلا
+
+72
+00:05:57,660 --> 00:06:02,780
+اللي هو ال strips اللي بتستخدم في بعض الفحوصات هذه
+
+73
+00:06:02,780 --> 00:06:08,260
+في منها اللي هي مجلوب A و C لكن هذه مش لازم تستخدم
+
+74
+00:06:08,260 --> 00:06:13,460
+لل diagnoses أيضا من الفحوصات اللي ممكن استخدمها
+
+75
+00:06:13,460 --> 00:06:18,280
+اللي fasting plasma glucoseوإيه عندنا؟ اللي هو الـ
+
+76
+00:06:18,280 --> 00:06:22,740
+concentration إذا كان 126 milligram per deciliter
+
+77
+00:06:22,740 --> 00:06:28,820
+أو أعلى معناته الشخص ممكن نقول إنه هندو ديابيتاس
+
+78
+00:06:28,820 --> 00:06:31,540
+ماليتاس fasting is defined as non calorie intake
+
+79
+00:06:31,540 --> 00:06:34,460
+for at least eight hours طبعا لازم يكون الشخص صايم
+
+80
+00:06:34,460 --> 00:06:41,440
+على الأقل تمام ساعته symptoms
+
+81
+00:06:41,440 --> 00:06:47,360
+of hyperglycemia and casual plasma glucoseof two
+
+82
+00:06:47,360 --> 00:06:52,780
+hundred milligram per deciliter or greater اللي
+
+83
+00:06:52,780 --> 00:06:57,980
+هو ال .. ال casual plasma aglucose اللي هو فحص
+
+84
+00:06:57,980 --> 00:07:03,330
+يعني ال aglucose في أي وقتخلال اليوم without
+
+85
+00:07:03,330 --> 00:07:07,530
+regard to time since the last meet، اللي هو random
+
+86
+00:07:07,530 --> 00:07:11,450
+يعني، يعني casual أو random blood glucose، لأن كان
+
+87
+00:07:11,450 --> 00:07:17,450
+في symptoms موجودة للارتفاع من سوء السكر بالدم، مع
+
+88
+00:07:17,450 --> 00:07:22,540
+casual plasma glucose أو random plasma glucoseالـ
+
+89
+00:07:22,540 --> 00:07:26,160
+Concentration 200 mg per deciliter أو أكتر هي برضه
+
+90
+00:07:26,160 --> 00:07:29,880
+هذا ممكن اللي وقتين تشخيصه على أنه عنده type two
+
+91
+00:07:29,880 --> 00:07:32,720
+على أنه عنده diabetes mellitus the classic
+
+92
+00:07:32,720 --> 00:07:35,220
+symptoms of hyperglycemia include polyuria
+
+93
+00:07:35,220 --> 00:07:42,740
+polydipsia and unexplained weight loss أيضا فحص
+
+94
+00:07:42,740 --> 00:07:46,040
+آخر اللي هو الـ Oral Glucose Tolerance Test
+
+95
+00:07:46,040 --> 00:07:52,880
+باستخدام هذا الفحص إذا كان بعد ساعتينمن إعطاء
+
+96
+00:07:52,880 --> 00:08:00,080
+الجرعة للجلوكوز لـ 75 جرام بعد ساعتين إذا طلعت أن
+
+97
+00:08:00,080 --> 00:08:03,380
+الـ concentration لـ plasma glucose أكتر من 200
+
+98
+00:08:03,380 --> 00:08:08,320
+ميلي جرام per deciliter أي بمعناته برضه هذا الشخص
+
+99
+00:08:08,320 --> 00:08:11,920
+can be diagnosed as having diabetes mellitus
+
+100
+00:08:15,840 --> 00:08:20,180
+يبقى إذا كان عندنا يعني الأمر مش واضح أو في laps
+
+101
+00:08:20,180 --> 00:08:25,840
+أو عندنا ارتفاع السكر بالدم مش واضح بشكل يعني كبير
+
+102
+00:08:25,840 --> 00:08:30,520
+يبقى this criteria should be confirmed by
+
+103
+00:08:30,520 --> 00:08:34,340
+repeating the same test on a different day لابد من
+
+104
+00:08:34,340 --> 00:08:39,720
+إعادة الفحص مرة أخرى اللي هو في اليوم التالي
+
+105
+00:08:39,720 --> 00:08:47,390
+لتأكيد أو نفي الإصابة بال diabetes mellitusبالنسبة
+
+106
+00:08:47,390 --> 00:08:50,690
+لـ complications طبعا قلنا إنه في complications
+
+107
+00:08:50,690 --> 00:08:54,530
+عديدة بتكون يعني مصاحبة للإصابة بالـ diabetes
+
+108
+00:08:54,530 --> 00:09:01,190
+mellitus والنتجة عن الارتفاع المستمر لجلوكوزالدم
+
+109
+00:09:01,190 --> 00:09:04,130
+patients with both type 1 and type 2 diabetes are
+
+110
+00:09:04,130 --> 00:09:07,230
+at high risk for the development of chronic
+
+111
+00:09:07,230 --> 00:09:10,930
+complications ومن هذه ال complications قلنا فيها
+
+112
+00:09:10,930 --> 00:09:15,570
+ان ال microvascular complications و اللي ممكن تؤدي
+
+113
+00:09:15,570 --> 00:09:20,030
+الى retinopathy، nephropathy أو neuropathy وعنا ال
+
+114
+00:09:20,030 --> 00:09:24,310
+microvascular complications اللي هي ممكن تؤدي الى
+
+115
+00:09:24,310 --> 00:09:28,930
+ال atherosclerosis و ال cardiovascular diseases
+
+116
+00:09:31,990 --> 00:09:39,710
+بما يتعلق بالـ molecular mechanisms المسؤولة عن ال
+
+117
+00:09:39,710 --> 00:09:44,330
+complications المختلفة الناتجة عن ارتفاع الجلوكوز
+
+118
+00:09:44,330 --> 00:09:50,230
+في الدم أن العديد من ال hypothesisوقد تم تفضيلها
+
+119
+00:09:50,230 --> 00:09:54,050
+لتشرح كيف تسبب الهيبرقليسيميا في الهيبرقليسيميا
+
+120
+00:09:54,050 --> 00:09:54,290
+الهيبرقليسيمية الهيبرقليسيمية الهيبرقليسيمية
+
+121
+00:09:54,290 --> 00:09:54,970
+الهيبرقليسيمية الهيبرقليسيمية الهيبرقليسيمية
+
+122
+00:09:54,970 --> 00:09:58,650
+الهيبرقليسيمية الهيبرقليسيمية الهيبرقليسيمية
+
+123
+00:09:58,650 --> 00:10:03,510
+الهيبرقليسيمية الهيبرقليسيمية الهيبرقليسيمية
+
+124
+00:10:03,510 --> 00:10:04,510
+الهيبرقليسيمية الهيبرقليسيمية الهيبرقليسيمية
+
+125
+00:10:04,510 --> 00:10:04,550
+الهيبرقليسيمية الهيبرقليسيمية الهيبرقليسيمية
+
+126
+00:10:04,550 --> 00:10:10,690
+الهيبرقليسيمية الهيبرقليسيمية الهيبرقليسيماللي هو
+
+127
+00:10:10,690 --> 00:10:14,410
+زي ال .. اللي هو الـ Hemoglobin A1C أو زي اللي هو
+
+128
+00:10:14,410 --> 00:10:20,730
+ال .. الـ Glucated albumin ال activation للبروتين
+
+129
+00:10:20,730 --> 00:10:27,090
+كينيز C و ال activation للبروتين كينيز C ممكن ازيد
+
+130
+00:10:27,090 --> 00:10:31,210
+من ال oxidative stress production of super oxide
+
+131
+00:10:31,210 --> 00:10:35,650
+and other reactive oxygen species اللي هو عن طريق
+
+132
+00:10:35,650 --> 00:10:39,130
+ال mitochondrial electron transported chainبرضه أن
+
+133
+00:10:39,130 --> 00:10:43,370
+الـ endoplasmic reticulum stress increased
+
+134
+00:10:43,370 --> 00:10:48,850
+hexosamine pathway flux و ال activation of
+
+135
+00:10:48,850 --> 00:10:52,270
+sarcomergic-II domain containing phosphatase-I الو
+
+136
+00:10:52,270 --> 00:11:02,890
+ال SHP-I الأن كل هذه ال .. ال mechanisms اللي رابط
+
+137
+00:11:02,890 --> 00:11:10,240
+بينهاهو الـ Overproduction of Super Oxide يبقى
+
+138
+00:11:10,240 --> 00:11:16,540
+عندنا المشكلة الأساسية هي زيادة الـ Reactive
+
+139
+00:11:16,540 --> 00:11:22,260
+Oxygen Species وهذا اللي هو العامل المشترك بين كل
+
+140
+00:11:22,260 --> 00:11:29,660
+الـ Molecular Mechanisms اللي ذكرناهاوالعديد من
+
+141
+00:11:29,660 --> 00:11:34,200
+الـ clinical trials are underway using novel
+
+142
+00:11:34,200 --> 00:11:37,580
+therapies specifically directed at the signaling
+
+143
+00:11:37,580 --> 00:11:41,100
+molecules اللي هو زي البروتين كينايت C اللي قلنا
+
+144
+00:11:41,100 --> 00:11:44,720
+بزيد من ال .. ال .. ال oxidative stress أو
+
+145
+00:11:44,720 --> 00:11:50,580
+باستخدام antioxidants to neutralize the effects of
+
+146
+00:11:50,580 --> 00:11:54,470
+the oxidants لأنه زي ما قلناالعامل المشترك
+
+147
+00:11:54,470 --> 00:12:00,470
+والمشكلة الناتجة عن كل ال mechanisms هو ال .. ال
+
+148
+00:12:00,470 --> 00:12:03,070
+oxidants أو الزيادة في ال reactive oxygen species
+
+149
+00:12:03,070 --> 00:12:07,550
+وبالتالي إذا كان احنا تعاملنا مع ال reactive
+
+150
+00:12:07,550 --> 00:12:13,970
+oxygen species وقللناها يبقى ممكن يعني هذا مستقبلا
+
+151
+00:12:13,970 --> 00:12:16,630
+يعني يكون حل
+
+152
+00:12:19,440 --> 00:12:24,400
+أو يعني يكون حل ال complications اللي خاصة بال
+
+153
+00:12:24,400 --> 00:12:32,160
+diabetes malatus هيك بيكون انتهينا من الجزء الأول
+
+154
+00:12:32,160 --> 00:12:36,500
+من محاضرة ال diabetes malatus و يعطيكوا الف عافية
+
diff --git a/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/sOPZ3-OZ39g_raw.json b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/sOPZ3-OZ39g_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..c7dc274e3691f580b7ca9dc59ef0526a8dd09692
--- /dev/null
+++ b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/sOPZ3-OZ39g_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 3022, "start": 2.46, "end": 30.22, "text": "maturity onset diabetes of the young أو مودي initial success in the search for ديابات و genes was seen in maturity onset diabetes of the young يعني أول نجاح في ربط المشكلات اللي بتصير في بعض ال genes و ال diabetes المودي عبارة عن rare group of disorders characterized by non-ketotic diabetes", "tokens": [76, 267, 3051, 34948, 13881, 295, 264, 2037, 34051, 3714, 2407, 16254, 5883, 2245, 294, 264, 3164, 337, 11778, 1829, 16758, 9307, 4032, 14424, 390, 1612, 294, 28874, 34948, 13881, 295, 264, 2037, 37495, 22653, 5551, 12610, 8717, 7435, 39319, 8978, 12602, 3555, 9566, 9673, 8592, 28820, 9307, 13672, 1829, 39894, 9381, 13546, 8978, 45030, 11242, 2423, 14424, 4032, 2423, 13881, 9673, 2407, 16254, 6225, 3555, 9640, 3660, 18871, 5892, 1594, 295, 20261, 29361, 538, 2107, 12, 5758, 9411, 13881], "avg_logprob": -0.184606475594603, "compression_ratio": 1.5720524017467248, "no_speech_prob": 0.0, "words": [{"start": 2.46, 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diagnosis of diabetes mellitus طبعا ال diagnosis بتايم باستخدام الفحوصات المختلفة أو أي من الفحوصات اللي ممكن نستخدمها فينا ال hemoglobin A1c ال cut-off point لو ستة و خمسة بالمية or greater", "tokens": [9566, 1829, 3555, 8717, 47432, 3660, 5551, 34740, 7578, 2423, 11101, 337, 15217, 295, 13881, 385, 285, 30973, 23032, 3555, 3615, 995, 2423, 15217, 39894, 995, 32640, 4724, 995, 14851, 9778, 3215, 10943, 27188, 5016, 2407, 9381, 9307, 9673, 46456, 46538, 3660, 34051, 36632, 9154, 27188, 5016, 2407, 9381, 9307, 13672, 1829, 3714, 43020, 8717, 14851, 9778, 40448, 11296, 8978, 8315, 2423, 8636, 45841, 13496, 316, 16, 66, 2423, 1723, 12, 4506, 935, 45164, 8608, 2655, 3660, 4032, 16490, 2304, 3794, 3660, 20666, 2304, 10632, 420, 5044], "avg_logprob": -0.22887073220177132, "compression_ratio": 1.511737089201878, "no_speech_prob": 6.556510925292969e-07, "words": [{"start": 266.96, "end": 267.26, "word": "طيب", "probability": 0.798095703125}, {"start": 267.26, "end": 267.74, "word": " نقطة", 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728.47, "end": 729.39, "word": " وقللناها", "probability": 0.9269205729166666}, {"start": 729.39, "end": 730.23, "word": " يبقى", "probability": 0.8709716796875}, {"start": 730.23, "end": 731.25, "word": " ممكن", "probability": 0.9892578125}, {"start": 731.25, "end": 731.81, "word": " يعني", "probability": 0.971435546875}, {"start": 731.81, "end": 733.23, "word": " هذا", "probability": 0.95703125}, {"start": 733.23, "end": 733.97, "word": " مستقبلا", "probability": 0.957421875}, {"start": 733.97, "end": 734.29, "word": " يعني", "probability": 0.9638671875}, {"start": 734.29, "end": 734.81, "word": " يكون", "probability": 0.98193359375}, {"start": 734.81, "end": 736.63, "word": " حل", "probability": 0.984619140625}], "temperature": 1.0}, {"id": 32, "seek": 75650, "start": 739.44, "end": 756.5, "text": "أو يعني يكون حل ال complications اللي خاصة بال diabetes malatus هيك بيكون انتهينا من الجزء الأول من محاضرة ال diabetes malatus و يعطيكوا الف عافية", "tokens": [10721, 2407, 37495, 22653, 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{"start": 753.0, "end": 753.32, "word": " ال", "probability": 0.95703125}, {"start": 753.32, "end": 753.72, "word": " diabetes", "probability": 0.91455078125}, {"start": 753.72, "end": 754.52, "word": " malatus", "probability": 0.941162109375}, {"start": 754.52, "end": 754.76, "word": " و", "probability": 0.9375}, {"start": 754.76, "end": 755.5, "word": " يعطيكوا", "probability": 0.81279296875}, {"start": 755.5, "end": 755.98, "word": " الف", "probability": 0.57763671875}, {"start": 755.98, "end": 756.5, "word": " عافية", "probability": 0.9568684895833334}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 757.7135625, "duration_after_vad": 716.2931250000007}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/sOPZ3-OZ39g_raw.srt b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/sOPZ3-OZ39g_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..095a107136d8fe21bc8fcbc0649814d94cda0966
--- /dev/null
+++ b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/sOPZ3-OZ39g_raw.srt
@@ -0,0 +1,616 @@
+1
+00:00:02,460 --> 00:00:06,760
+maturity onset diabetes of the young أو مودي
+
+2
+00:00:06,760 --> 00:00:11,360
+initial success in the search for ديابات و genes
+
+3
+00:00:11,360 --> 00:00:14,520
+was seen in maturity onset diabetes of the young
+
+4
+00:00:14,520 --> 00:00:20,400
+يعني أول نجاح في ربط المشكلات اللي بتصير في بعض ال
+
+5
+00:00:20,400 --> 00:00:26,080
+genes و ال diabetes المودي عبارة عن rare group of
+
+6
+00:00:26,080 --> 00:00:30,220
+disorders characterized by non-ketotic diabetes
+
+7
+00:00:33,710 --> 00:00:37,030
+الشيء اللي يشبه الـ Type 2 diabetes mellitus هو أن
+
+8
+00:00:37,030 --> 00:00:43,470
+الموضي يموت في عمر صغير وعشان هيك بيصير في بعض
+
+9
+00:00:43,470 --> 00:00:46,450
+الحالات اللي هي الموضي بيتم تشخيص علي إنها Type 2
+
+10
+00:00:46,450 --> 00:00:52,670
+diabetes mellitusلكن الفرق أن الـ Modi بتصير at a
+
+11
+00:00:52,670 --> 00:00:58,610
+younger age اللي هو أقل من 25 سنة لكن الآن مع ال
+
+12
+00:00:58,610 --> 00:01:03,570
+.. برضه الإصابة بالـ type 2 diabetes mellitus برضه
+
+13
+00:01:03,570 --> 00:01:07,070
+at younger age برضه هان ممكن يصير في عنا يعني
+
+14
+00:01:07,070 --> 00:01:09,950
+مشكلة و لبس فيه التشخيص
+
+15
+00:01:12,470 --> 00:01:18,230
+يبقى young، non-obese patients with diabetes who
+
+16
+00:01:18,230 --> 00:01:22,990
+have a family history of diabetes يبقى كمان بيكون
+
+17
+00:01:22,990 --> 00:01:27,090
+فيه يعني تاريخ للعائلة الإصابة بالديابيتس، younger
+
+18
+00:01:27,090 --> 00:01:31,850
+age و non-obese A clinical spectrum of Maudi is
+
+19
+00:01:31,850 --> 00:01:36,550
+broad ranging from asymptomatic hyperglycemia to
+
+20
+00:01:36,550 --> 00:01:41,290
+an acute presentationيبقى ممكن الناس اللي عندهم
+
+21
+00:01:41,290 --> 00:01:46,230
+موضي يعني يعيش حياة طبيعية بدون ما يكون في عنده أي
+
+22
+00:01:46,230 --> 00:01:52,630
+مشكلة يعني يكون فقط أنه في ارتفاع اللي هو يعني
+
+23
+00:01:52,630 --> 00:01:58,650
+بسيط في ال glucoseهدول المرضى يعني احنا مافيش
+
+24
+00:01:58,650 --> 00:02:03,190
+symptoms وبالتالي ممكن يتم اكتشافهم صدفة يعني شخص
+
+25
+00:02:03,190 --> 00:02:08,210
+بيدروح ممكن يعمل بعض الفحوصات لسبب او لآخر ويتم
+
+26
+00:02:08,210 --> 00:02:13,930
+الاكتشاف انه في عنده hyperglycemia thirteen genes
+
+27
+00:02:13,930 --> 00:02:16,630
+are associated with this disorder
+
+28
+00:02:19,950 --> 00:02:23,990
+طبعا في ال .. اللي هو بناء على المشكلة في أن أنواع
+
+29
+00:02:23,990 --> 00:02:29,630
+مختلفة من المودي المودي tworesult from mutations
+
+30
+00:02:29,630 --> 00:02:34,570
+in the gene that encodes a glucokinase وبالتالي
+
+31
+00:02:34,570 --> 00:02:38,450
+هذا بيؤدي إلى partial deficiency of insulin
+
+32
+00:02:38,450 --> 00:02:43,370
+secretion بيبصير فينا نقص في إفراز الإنسولين وهذا
+
+33
+00:02:43,370 --> 00:02:48,090
+بيكون في المودي 2 طبعا هذا بيكون سبب ارتفاع
+
+34
+00:02:48,090 --> 00:02:55,060
+الجلوكوز في الدمالأنواع الأخرى من الموضي caused by
+
+35
+00:02:55,060 --> 00:02:58,300
+mutations in the genes that encode transcription
+
+36
+00:02:58,300 --> 00:03:05,680
+factors يبقى المشكلة في ال genes اللي بتؤدي إلى
+
+37
+00:03:05,680 --> 00:03:09,280
+تكوين اللي هو ال transcription factors واللي
+
+38
+00:03:09,280 --> 00:03:10,880
+مسئولة عن
+
+39
+00:03:13,180 --> 00:03:16,980
+الـ regulation لـ expression of different genes in
+
+40
+00:03:16,980 --> 00:03:21,340
+the pancreatic beta cells وما زال لأن المشكلة في
+
+41
+00:03:21,340 --> 00:03:24,600
+ال expression لجنس في ال pancreatic beta cells
+
+42
+00:03:24,600 --> 00:03:30,580
+يبقى هذا هيؤدي إلى impaired insulin synthesis أو
+
+43
+00:03:30,580 --> 00:03:36,320
+secretion أو ممكن يؤدي إلى reduced beta cell mass
+
+44
+00:03:38,650 --> 00:03:41,830
+mode mutations have substitution بقى المشكلات اللي
+
+45
+00:03:41,830 --> 00:03:44,630
+أو ال mutations اللي ممكن تكون موجودة في الأنواع
+
+46
+00:03:44,630 --> 00:03:49,590
+المختلفة substitution, deletion أو insertion of
+
+47
+00:03:49,590 --> 00:03:54,150
+nucleotides in the coding region of the genes طبعا
+
+48
+00:03:54,150 --> 00:04:01,090
+ممكن الكشف عن ال mutations المختلفة من خلال ال PCR
+
+49
+00:04:03,610 --> 00:04:06,450
+عنا الـ Orange Glucose Reliance Test و الـ Islet
+
+50
+00:04:06,450 --> 00:04:10,770
+O2 Antibodies و الـ C-Peptide هدول ممكن يساعدوا
+
+51
+00:04:10,770 --> 00:04:15,930
+على الـ differentiation بين المودي و الـ Type 1 أو
+
+52
+00:04:15,930 --> 00:04:21,170
+الـ Type 2 Diabetes لكن الـ genetic test مطلوبة
+
+53
+00:04:21,170 --> 00:04:28,860
+لتأكيد ال diagnosis of موديطيب نقطة أخرى ال
+
+54
+00:04:28,860 --> 00:04:33,480
+criteria for diagnosis of diabetes mellitus طبعا
+
+55
+00:04:33,480 --> 00:04:37,740
+ال diagnosis بتايم باستخدام الفحوصات المختلفة أو
+
+56
+00:04:37,740 --> 00:04:40,780
+أي من الفحوصات اللي ممكن نستخدمها فينا ال
+
+57
+00:04:40,780 --> 00:04:47,560
+hemoglobin A1c ال cut-off point لو ستة و خمسة
+
+58
+00:04:47,560 --> 00:04:55,380
+بالمية or greaterو 6.5% أو أكتر معناته بنقول أن
+
+59
+00:04:55,380 --> 00:04:58,640
+الشخص عنده diabetes mellitus test should be
+
+60
+00:04:58,640 --> 00:05:02,300
+performed in a laboratory using a method that is
+
+61
+00:05:02,300 --> 00:05:07,780
+NGSP certified يبقى عندنا فيه طرق عديدة لفحص ال
+
+62
+00:05:07,780 --> 00:05:12,680
+hemoglobin A1C لكن إذا كنا نستخدم فحص ال
+
+63
+00:05:12,680 --> 00:05:18,870
+hemoglobin A1C لال diagnosisof diabetes لابد إنه
+
+64
+00:05:18,870 --> 00:05:24,270
+يكون standardized test و ال standardized test هذا
+
+65
+00:05:24,270 --> 00:05:30,590
+يعني بدي يكون ماخد certificate من جهة اللي تسمى ال
+
+66
+00:05:30,590 --> 00:05:35,510
+NGSB national glycohemoglobin standardization
+
+67
+00:05:35,510 --> 00:05:40,050
+program تمام، هي مش أي kit موجودة بالسوق ممكن
+
+68
+00:05:40,050 --> 00:05:45,310
+نستخدمها تمام، لازم تكون اللي هي certified من ال
+
+69
+00:05:45,310 --> 00:05:46,330
+NGSB
+
+70
+00:05:48,500 --> 00:05:51,720
+a point of care assay should not be used for
+
+71
+00:05:51,720 --> 00:05:57,660
+diagnoses اللي هي ال point of care assay زي مثلا
+
+72
+00:05:57,660 --> 00:06:02,780
+اللي هو ال strips اللي بتستخدم في بعض الفحوصات هذه
+
+73
+00:06:02,780 --> 00:06:08,260
+في منها اللي هي مجلوب A و C لكن هذه مش لازم تستخدم
+
+74
+00:06:08,260 --> 00:06:13,460
+لل diagnoses أيضا من الفحوصات اللي ممكن استخدمها
+
+75
+00:06:13,460 --> 00:06:18,280
+اللي fasting plasma glucoseوإيه عندنا؟ اللي هو الـ
+
+76
+00:06:18,280 --> 00:06:22,740
+concentration إذا كان 126 milligram per deciliter
+
+77
+00:06:22,740 --> 00:06:28,820
+أو أعلى معناته الشخص ممكن نقول إنه هندو ديابيتاس
+
+78
+00:06:28,820 --> 00:06:31,540
+ماليتاس fasting is defined as non calorie intake
+
+79
+00:06:31,540 --> 00:06:34,460
+for at least eight hours طبعا لازم يكون الشخص صايم
+
+80
+00:06:34,460 --> 00:06:41,440
+على الأقل تمام ساعته symptoms
+
+81
+00:06:41,440 --> 00:06:47,360
+of hyperglycemia and casual plasma glucoseof two
+
+82
+00:06:47,360 --> 00:06:52,780
+hundred milligram per deciliter or greater اللي
+
+83
+00:06:52,780 --> 00:06:57,980
+هو ال .. ال casual plasma aglucose اللي هو فحص
+
+84
+00:06:57,980 --> 00:07:03,330
+يعني ال aglucose في أي وقتخلال اليوم without
+
+85
+00:07:03,330 --> 00:07:07,530
+regard to time since the last meet، اللي هو random
+
+86
+00:07:07,530 --> 00:07:11,450
+يعني، يعني casual أو random blood glucose، لأن كان
+
+87
+00:07:11,450 --> 00:07:17,450
+في symptoms موجودة للارتفاع من سوء السكر بالدم، مع
+
+88
+00:07:17,450 --> 00:07:22,540
+casual plasma glucose أو random plasma glucoseالـ
+
+89
+00:07:22,540 --> 00:07:26,160
+Concentration 200 mg per deciliter أو أكتر هي برضه
+
+90
+00:07:26,160 --> 00:07:29,880
+هذا ممكن اللي وقتين تشخيصه على أنه عنده type two
+
+91
+00:07:29,880 --> 00:07:32,720
+على أنه عنده diabetes mellitus the classic
+
+92
+00:07:32,720 --> 00:07:35,220
+symptoms of hyperglycemia include polyuria
+
+93
+00:07:35,220 --> 00:07:42,740
+polydipsia and unexplained weight loss أيضا فحص
+
+94
+00:07:42,740 --> 00:07:46,040
+آخر اللي هو الـ Oral Glucose Tolerance Test
+
+95
+00:07:46,040 --> 00:07:52,880
+باستخدام هذا الفحص إذا كان بعد ساعتينمن إعطاء
+
+96
+00:07:52,880 --> 00:08:00,080
+الجرعة للجلوكوز لـ 75 جرام بعد ساعتين إذا طلعت أن
+
+97
+00:08:00,080 --> 00:08:03,380
+الـ concentration لـ plasma glucose أكتر من 200
+
+98
+00:08:03,380 --> 00:08:08,320
+ميلي جرام per deciliter أي بمعناته برضه هذا الشخص
+
+99
+00:08:08,320 --> 00:08:11,920
+can be diagnosed as having diabetes mellitus
+
+100
+00:08:15,840 --> 00:08:20,180
+يبقى إذا كان عندنا يعني الأمر مش واضح أو في laps
+
+101
+00:08:20,180 --> 00:08:25,840
+أو عندنا ارتفاع السكر بالدم مش واضح بشكل يعني كبير
+
+102
+00:08:25,840 --> 00:08:30,520
+يبقى this criteria should be confirmed by
+
+103
+00:08:30,520 --> 00:08:34,340
+repeating the same test on a different day لابد من
+
+104
+00:08:34,340 --> 00:08:39,720
+إعادة الفحص مرة أخرى اللي هو في اليوم التالي
+
+105
+00:08:39,720 --> 00:08:47,390
+لتأكيد أو نفي الإصابة بال diabetes mellitusبالنسبة
+
+106
+00:08:47,390 --> 00:08:50,690
+لـ complications طبعا قلنا إنه في complications
+
+107
+00:08:50,690 --> 00:08:54,530
+عديدة بتكون يعني مصاحبة للإصابة بالـ diabetes
+
+108
+00:08:54,530 --> 00:09:01,190
+mellitus والنتجة عن الارتفاع المستمر لجلوكوزالدم
+
+109
+00:09:01,190 --> 00:09:04,130
+patients with both type 1 and type 2 diabetes are
+
+110
+00:09:04,130 --> 00:09:07,230
+at high risk for the development of chronic
+
+111
+00:09:07,230 --> 00:09:10,930
+complications ومن هذه ال complications قلنا فيها
+
+112
+00:09:10,930 --> 00:09:15,570
+ان ال microvascular complications و اللي ممكن تؤدي
+
+113
+00:09:15,570 --> 00:09:20,030
+الى retinopathy، nephropathy أو neuropathy وعنا ال
+
+114
+00:09:20,030 --> 00:09:24,310
+microvascular complications اللي هي ممكن تؤدي الى
+
+115
+00:09:24,310 --> 00:09:28,930
+ال atherosclerosis و ال cardiovascular diseases
+
+116
+00:09:31,990 --> 00:09:39,710
+بما يتعلق بالـ molecular mechanisms المسؤولة عن ال
+
+117
+00:09:39,710 --> 00:09:44,330
+complications المختلفة الناتجة عن ارتفاع الجلوكوز
+
+118
+00:09:44,330 --> 00:09:50,230
+في الدم أن العديد من ال hypothesisوقد تم تفضيلها
+
+119
+00:09:50,230 --> 00:09:54,050
+لتشرح كيف تسبب الهيبرقليسيميا في الهيبرقليسيميا
+
+120
+00:09:54,050 --> 00:09:54,290
+الهيبرقليسيمية الهيبرقليسيمية الهيبرقليسيمية
+
+121
+00:09:54,290 --> 00:09:54,970
+الهيبرقليسيمية الهيبرقليسيمية الهيبرقليسيمية
+
+122
+00:09:54,970 --> 00:09:58,650
+الهيبرقليسيمية الهيبرقليسيمية الهيبرقليسيمية
+
+123
+00:09:58,650 --> 00:10:03,510
+الهيبرقليسيمية الهيبرقليسيمية الهيبرقليسيمية
+
+124
+00:10:03,510 --> 00:10:04,510
+الهيبرقليسيمية الهيبرقليسيمية الهيبرقليسيمية
+
+125
+00:10:04,510 --> 00:10:04,550
+الهيبرقليسيمية الهيبرقليسيمية الهيبرقليسيمية
+
+126
+00:10:04,550 --> 00:10:10,690
+الهيبرقليسيمية الهيبرقليسيمية الهيبرقليسيماللي هو
+
+127
+00:10:10,690 --> 00:10:14,410
+زي ال .. اللي هو الـ Hemoglobin A1C أو زي اللي هو
+
+128
+00:10:14,410 --> 00:10:20,730
+ال .. الـ Glucated albumin ال activation للبروتين
+
+129
+00:10:20,730 --> 00:10:27,090
+كينيز C و ال activation للبروتين كينيز C ممكن ازيد
+
+130
+00:10:27,090 --> 00:10:31,210
+من ال oxidative stress production of super oxide
+
+131
+00:10:31,210 --> 00:10:35,650
+and other reactive oxygen species اللي هو عن طريق
+
+132
+00:10:35,650 --> 00:10:39,130
+ال mitochondrial electron transported chainبرضه أن
+
+133
+00:10:39,130 --> 00:10:43,370
+الـ endoplasmic reticulum stress increased
+
+134
+00:10:43,370 --> 00:10:48,850
+hexosamine pathway flux و ال activation of
+
+135
+00:10:48,850 --> 00:10:52,270
+sarcomergic-II domain containing phosphatase-I الو
+
+136
+00:10:52,270 --> 00:11:02,890
+ال SHP-I الأن كل هذه ال .. ال mechanisms اللي رابط
+
+137
+00:11:02,890 --> 00:11:10,240
+بينهاهو الـ Overproduction of Super Oxide يبقى
+
+138
+00:11:10,240 --> 00:11:16,540
+عندنا المشكلة الأساسية هي زيادة الـ Reactive
+
+139
+00:11:16,540 --> 00:11:22,260
+Oxygen Species وهذا اللي هو العامل المشترك بين كل
+
+140
+00:11:22,260 --> 00:11:29,660
+الـ Molecular Mechanisms اللي ذكرناهاوالعديد من
+
+141
+00:11:29,660 --> 00:11:34,200
+الـ clinical trials are underway using novel
+
+142
+00:11:34,200 --> 00:11:37,580
+therapies specifically directed at the signaling
+
+143
+00:11:37,580 --> 00:11:41,100
+molecules اللي هو زي البروتين كينايت C اللي قلنا
+
+144
+00:11:41,100 --> 00:11:44,720
+بزيد من ال .. ال .. ال oxidative stress أو
+
+145
+00:11:44,720 --> 00:11:50,580
+باستخدام antioxidants to neutralize the effects of
+
+146
+00:11:50,580 --> 00:11:54,470
+the oxidants لأنه زي ما قلناالعامل المشترك
+
+147
+00:11:54,470 --> 00:12:00,470
+والمشكلة الناتجة عن كل ال mechanisms هو ال .. ال
+
+148
+00:12:00,470 --> 00:12:03,070
+oxidants أو الزيادة في ال reactive oxygen species
+
+149
+00:12:03,070 --> 00:12:07,550
+وبالتالي إذا كان احنا تعاملنا مع ال reactive
+
+150
+00:12:07,550 --> 00:12:13,970
+oxygen species وقللناها يبقى ممكن يعني هذا مستقبلا
+
+151
+00:12:13,970 --> 00:12:16,630
+يعني يكون حل
+
+152
+00:12:19,440 --> 00:12:24,400
+أو يعني يكون حل ال complications اللي خاصة بال
+
+153
+00:12:24,400 --> 00:12:32,160
+diabetes malatus هيك بيكون انتهينا من الجزء الأول
+
+154
+00:12:32,160 --> 00:12:36,500
+من محاضرة ال diabetes malatus و يعطيكوا الف عافية
+
diff --git a/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/wNcigeivKdA.srt b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/wNcigeivKdA.srt
new file mode 100644
index 0000000000000000000000000000000000000000..ad6b6c9d8f80516577ed7270e044c42a24528e55
--- /dev/null
+++ b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/wNcigeivKdA.srt
@@ -0,0 +1,1534 @@
+1
+00:00:01,840 --> 00:00:06,080
+بسم الله الرحمن الرحيم نستكمل مع محاضرة diabetes
+
+2
+00:00:06,080 --> 00:00:12,940
+mellitus ووصلنا لغاية ال insulin و ال antibodies
+
+3
+00:00:12,940 --> 00:00:14,260
+to insulin
+
+4
+00:00:16,690 --> 00:00:22,170
+الجسم ممكن ينتج antibody against the exogenous
+
+5
+00:00:22,170 --> 00:00:29,850
+انسولين يعني الناس اللي بتعالجوا بالانسولين ممكن
+
+6
+00:00:29,850 --> 00:00:34,950
+يصير في antibodies أو الجسم ينتج antibodies ضد هذا
+
+7
+00:00:34,950 --> 00:00:40,550
+الانسولين وهذا بنطلق عليه exogenous insulin
+
+8
+00:00:40,550 --> 00:00:42,470
+antibody syndrome
+
+9
+00:00:44,970 --> 00:00:48,690
+الـ these antibodies are usually present at low
+
+10
+00:00:48,690 --> 00:00:52,410
+titers يبقى ال concentration لل antibodies هذي
+
+11
+00:00:52,410 --> 00:00:59,230
+بتكون قليلة ويعني مابيكونش في عنا أي نتائج يعني
+
+12
+00:00:59,230 --> 00:01:05,350
+عكسية on real...real occasions high titers of
+
+13
+00:01:05,350 --> 00:01:08,850
+insulin antibodies may cause insulin resistance
+
+14
+00:01:10,760 --> 00:01:17,380
+وهذا بيصير بشكل خاص في الناس اللي عندهم type 2
+
+15
+00:01:17,380 --> 00:01:21,160
+diabetes mellitus و اللي يعني بالمراحل متقدمة من
+
+16
+00:01:21,160 --> 00:01:29,600
+المرض و اللي بدوا ياخدوا insulin ضمن العلاج يبقى
+
+17
+00:01:29,600 --> 00:01:34,100
+بهذه الحالة ممكن يصير فينا ارتفاع في ال
+
+18
+00:01:34,100 --> 00:01:40,730
+concentrations لل insulin antibodiesو هذا الارتفاع
+
+19
+00:01:40,730 --> 00:01:44,890
+سيؤدي إلى insulin resistance
+
+20
+00:01:46,610 --> 00:01:50,570
+كيف يتم التعامل مع هدول المرضى؟ فيه أنه several
+
+21
+00:01:50,570 --> 00:01:54,750
+therapeutic approaches for treating these patients
+
+22
+00:01:54,750 --> 00:01:58,110
+ومن ضمن ال approaches أنه يصير فيه double
+
+23
+00:01:58,110 --> 00:02:04,670
+filtration بلازمافوريس أو يصير فيه plasma exchange
+
+24
+00:02:04,670 --> 00:02:11,110
+لمدة two weeks بالإضافة لـأعطاه هدول المرضى
+
+25
+00:02:11,110 --> 00:02:17,630
+prednisolone اللي هو synthetic hydrocortisone وهذا
+
+26
+00:02:17,630 --> 00:02:21,350
+طبعا اللي هو هيعمل على يعني تقليل ال immune
+
+27
+00:02:21,350 --> 00:02:23,030
+response
+
+28
+00:02:24,740 --> 00:02:29,660
+أيضا في هذه الحالات انه يعني يضل فينا متابع ويعني
+
+29
+00:02:29,660 --> 00:02:35,540
+يتم عمل ال quantitative estimate لإن ال
+
+30
+00:02:35,540 --> 00:02:39,300
+concentration of the circulating insulin
+
+31
+00:02:39,300 --> 00:02:42,980
+antibodies does not appear to be of significant
+
+32
+00:02:42,980 --> 00:02:46,940
+benefit يعني مش هيفيدكتير ما زال عارفنا أنه في
+
+33
+00:02:46,940 --> 00:02:51,100
+عندنا antibodies و ال antibodies هذه يعني إلها
+
+34
+00:02:51,100 --> 00:02:54,240
+مفعول
+
+35
+00:02:54,240 --> 00:02:58,100
+أو ممكن...ممكن تزيد من ال insulin resistance يبقى
+
+36
+00:02:58,100 --> 00:03:02,680
+بهذه الحالة زي ما قلنا بدنا اللي هو يعني يكون في
+
+37
+00:03:02,680 --> 00:03:08,300
+عندنا therapeutic approach و يتم التعامل مع المريض
+
+38
+00:03:08,300 --> 00:03:11,240
+من خلال اللي ذكرناه
+
+39
+00:03:13,520 --> 00:03:17,700
+التحسين في صحيحة الإنسولين الحيواني وإنسولين
+
+40
+00:03:17,700 --> 00:03:22,540
+الحيواني المتوسط قد أقل، ولكن ليس تقليلاً عن إنتاج
+
+41
+00:03:22,540 --> 00:03:29,320
+الإنسولين الحيواني يبقى مع الإنتاج للإنسولين
+
+42
+00:03:29,320 --> 00:03:33,680
+الحيواني وطبعاً يعني صار في ان اعتماد أقل على
+
+43
+00:03:33,680 --> 00:03:38,800
+الإنسولين الحيواني والصحيحة اللي بتصير درجة عالية
+
+44
+00:03:38,800 --> 00:03:45,370
+للإنسولين هذه قللت بشكل كبيرمن اللي هو ال
+
+45
+00:03:45,370 --> 00:03:49,130
+antibodies لـ
+
+46
+00:03:49,130 --> 00:03:53,490
+exogenous insulin لكن حتى مع ال purification
+
+47
+00:03:53,490 --> 00:03:59,990
+العالي و حتى مع الاستخدام لـ recombinant insulin
+
+48
+00:03:59,990 --> 00:04:04,770
+إلا أنه برضه يعني في ممكن يصير إنتاج ل antibodies
+
+49
+00:04:04,770 --> 00:04:12,820
+against ال exogenous insulinالاستخدام ليه يعني
+
+50
+00:04:12,820 --> 00:04:19,180
+ممكن نقول ال less invasive يعني ways او delivery
+
+51
+00:04:19,180 --> 00:04:27,940
+system لأ ال insulin للأسف هذه زادت من إنتاج ال
+
+52
+00:04:27,940 --> 00:04:33,110
+antibodies ضد ال exogenous insulinيبقى عندنا زي
+
+53
+00:04:33,110 --> 00:04:35,850
+اللي هو ال continuous subcutaneous insulin
+
+54
+00:04:35,850 --> 00:04:42,810
+infusion أو أيضا في اللي هو ال inhaled insulin has
+
+55
+00:04:42,810 --> 00:04:45,770
+resulted in significantly increased concentrations
+
+56
+00:04:45,770 --> 00:04:48,250
+of insulin antibodies
+
+57
+00:04:51,430 --> 00:04:54,630
+Antibodies to insulin really develop in patients
+
+58
+00:04:54,630 --> 00:04:58,770
+who have not received exogenous insulin يبقى
+
+59
+00:04:58,770 --> 00:05:03,870
+المشكلة الأساسية هو بالExogenous insulin يبقى لما
+
+60
+00:05:03,870 --> 00:05:08,030
+يصير في administration لExogenous insulin ممكن
+
+61
+00:05:08,030 --> 00:05:12,030
+تبدأ تتكون Antibodies ضد الانسلين
+
+62
+00:05:15,260 --> 00:05:19,820
+بما يتعلق بالتوصيات طيب هل يصير فيانا فحص مثلا
+
+63
+00:05:19,820 --> 00:05:26,120
+بشكل روتيني لناس اللي عندهم يعني diabetes و
+
+64
+00:05:26,120 --> 00:05:32,500
+بنعطيهم exogenous insulin أو لأ؟ يعني من التوصيات
+
+65
+00:05:32,500 --> 00:05:40,120
+أنه مايصيرش فيه يعني routine يعني quantitation أو
+
+66
+00:05:40,120 --> 00:05:45,670
+measurement لال insulinولكن ليس هناك اثارة لإدارة
+
+67
+00:05:45,670 --> 00:05:50,090
+استخدام الانسلين للتجارب للطبيعي للطبيعي للطيابين
+
+68
+00:05:50,090 --> 00:05:51,690
+اللي بيبتس
+
+69
+00:05:54,020 --> 00:05:58,740
+طبعا زي ما قولنا إنه من المشكلات اللي ممكن تنتج عن
+
+70
+00:05:58,740 --> 00:06:03,760
+وجود ال antibodies هذه وارتباطها مع الانسلين هو
+
+71
+00:06:03,760 --> 00:06:08,920
+حدوث الانسلين resistance وبالتالي هذا هيؤدي إلى
+
+72
+00:06:08,920 --> 00:06:16,350
+ارتفاع في ال postprandial blood glucose تمام، لأن
+
+73
+00:06:16,350 --> 00:06:20,470
+الـ Antibodies مرتبط للإنسلين، وبالتالي الإنسلين
+
+74
+00:06:20,470 --> 00:06:25,010
+مش هيقوم بعمله، والمشكلة التانية المتعلقة برضه
+
+75
+00:06:25,010 --> 00:06:30,530
+بهذا الأمر، إن ارتباط الـ Antibodies بالإنسلين
+
+76
+00:06:30,530 --> 00:06:34,870
+reversibleلما بيجي ال antibody مش هيضال مرتبط لو
+
+77
+00:06:34,870 --> 00:06:40,070
+تغيرت الظروف ممكن يفك الإرتباط بين ال insulin و
+
+78
+00:06:40,070 --> 00:06:43,470
+بين ال antibody وبالتالي هذا ممكن يزيد من ال
+
+79
+00:06:43,470 --> 00:06:48,410
+insulin concentration اللي موجودة بالدم وهذا اللي
+
+80
+00:06:48,410 --> 00:06:54,430
+ممكن يصير at night التغير فيهالـ pH at night ممكن
+
+81
+00:06:54,430 --> 00:06:59,670
+يعمل dissociation بين الإنسلين وبين الـ antibody
+
+82
+00:06:59,670 --> 00:07:04,930
+اللي كان مرتبط معاه وبالتالي يزيد من الـ ال
+
+83
+00:07:04,930 --> 00:07:08,690
+concentration للإنسلين وبالتالي ممكن يؤدي إلى
+
+84
+00:07:08,690 --> 00:07:14,490
+hypoglycemia أنها مشكلة تانية بتتعلق بال
+
+85
+00:07:14,490 --> 00:07:18,770
+antibodies هو إنتاج antibodies ضد الإنسلين
+
+86
+00:07:18,770 --> 00:07:27,650
+receptor وفي هذه الحالة أنه ممكن ينبج مشكلتين ال
+
+87
+00:07:27,650 --> 00:07:32,190
+antibodies هذه اللي هترتبط مع ال receptor ممكن
+
+88
+00:07:32,190 --> 00:07:38,350
+تشتغل ك antagonist وإذا اشتغلت ك antagonist معناه
+
+89
+00:07:38,350 --> 00:07:41,690
+طبعا هيصير فيه competition بينها و بين ال ال
+
+90
+00:07:41,690 --> 00:07:44,670
+insulin و هي هترتبط مع ال receptor و تمنع من
+
+91
+00:07:44,670 --> 00:07:51,820
+ارتباطالانسولين و هتؤدي الى حدوث hyperglycemia
+
+92
+00:07:51,820 --> 00:07:57,300
+وهذا اللى بيشوفوه فى حالات ال patients with
+
+93
+00:07:57,300 --> 00:08:05,080
+acanthosis nigricans اللى بيكون فى اللى هو يعني زى
+
+94
+00:08:05,080 --> 00:08:10,960
+epidermal skin cells begin to reproduce rapidly
+
+95
+00:08:10,960 --> 00:08:18,040
+فبصير فى تكاثر لخلايا بشكل كبيرو هذا بيعمل اللي هو
+
+96
+00:08:18,040 --> 00:08:23,320
+ال skin growth و بيبين اللي هو بالشكل زي اللي هو
+
+97
+00:08:23,320 --> 00:08:29,490
+الصورة دي سواء تحت القبض أو على اللي هو الرقبة وهذا
+
+98
+00:08:29,490 --> 00:08:32,850
+زي ما قلنا بيكون بسبب أنه في عندي antibodies ضد ال
+
+99
+00:08:32,850 --> 00:08:40,110
+receptors وهذا بيمنع من ارتباط ال...ال insulin
+
+100
+00:08:40,110 --> 00:08:45,890
+وبي...هذا بيؤدي إلى رفع مستويات ال insulin في
+
+101
+00:08:45,890 --> 00:08:50,870
+الجسم وبالتالي abnormal اللي هو skin cell growth
+
+102
+00:08:50,870 --> 00:08:55,470
+بهذا في حال أنه ال antibodies اشتغلت ك antagonist
+
+103
+00:08:55,960 --> 00:08:59,320
+لكن في عندنا حالة تانية ممكن هذه الـ Antibodies of
+
+104
+00:08:59,320 --> 00:09:03,320
+the Receptors تشتغل كـ agonists agonists يبقى
+
+105
+00:09:03,320 --> 00:09:09,260
+هتشتغل كأنه الإنسولين هو المرتبط وبالتالي هذا
+
+106
+00:09:09,260 --> 00:09:17,660
+هيؤدي إلى حدوث hypoglycemia عند الشخص بما يتعلق
+
+107
+00:09:17,660 --> 00:09:22,520
+بالـ Metabolism of Insulin Action التأثيرات
+
+108
+00:09:22,520 --> 00:09:29,320
+المتعلقة بالإنسولينيعني نوعًا ما باتت معروفة
+
+109
+00:09:29,320 --> 00:09:34,260
+ومفهومة يبقى الـ metabolic effects المختلفة لكن
+
+110
+00:09:34,260 --> 00:09:39,220
+على مستوى الـ molecular mechanism وكيف الـ Insulin
+
+111
+00:09:39,220 --> 00:09:44,300
+بيعمل هذه اللي هو التأثيرات المختلفة ويؤدي إلى الـ
+
+112
+00:09:44,300 --> 00:09:48,560
+different metabolic effects يعني ما زالت تحتاج إلى
+
+113
+00:09:48,560 --> 00:09:56,660
+مزيد من الفهم أكيد الخطوة الأولىليه الـ Insulin،
+
+114
+00:09:56,660 --> 00:09:59,920
+ليه القيام بعمله؟ هو الإرتباط مع الـ receptor
+
+115
+00:09:59,920 --> 00:10:06,020
+الخاص فيه على ال cell membrane يبقى بارتباط مع
+
+116
+00:10:06,020 --> 00:10:13,230
+specific receptors على ال plasma membraneوهذا الـ
+
+117
+00:10:13,230 --> 00:10:19,850
+Insulin receptor بتكون من أربع sub units وبالتالي
+
+118
+00:10:19,850 --> 00:10:25,030
+هو عبارة عن hetero tetrameribiana four proteins،
+
+119
+00:10:25,030 --> 00:10:28,570
+four sub units وهذه ال sub units عبارة عن two
+
+120
+00:10:28,570 --> 00:10:36,500
+alpha and two beta sub unitsالـ Alpha subunit is
+
+121
+00:10:36,500 --> 00:10:39,260
+located on the outer surface of the plasma
+
+122
+00:10:39,260 --> 00:10:45,180
+membrane and contains the site where insulin binds
+
+123
+00:10:45,180 --> 00:10:50,000
+وزي ما وضعنا بيه ال figure زي ما قولنا أن الـ
+
+124
+00:10:50,000 --> 00:10:55,460
+Alpha subunits هي اللي موجودة على اللواء الخارج من
+
+125
+00:10:55,460 --> 00:11:01,000
+ال receptor و هذه ال subunits اللي بيرتبط معها ال
+
+126
+00:11:01,000 --> 00:11:07,230
+insulin و ال beta subunitsعنا هذا اللي هو الـ
+
+127
+00:11:07,230 --> 00:11:10,150
+polypeptide فى جزء منه اللي هو الـ transmembrane
+
+128
+00:11:10,150 --> 00:11:17,950
+وفى عنا جزء اللي هو الـ cytoplasmic domain وارتباط
+
+129
+00:11:17,950 --> 00:11:23,550
+الإنسولين هذا يؤدي إلى حدوث confirmation change
+
+130
+00:11:23,550 --> 00:11:31,450
+بيه الـ beta sub unitsوالـ Insulin receptor يُعتبر
+
+131
+00:11:31,450 --> 00:11:40,430
+subfamily من الـ receptor tyrosine kinases وما زال
+
+132
+00:11:40,430 --> 00:11:46,150
+بنحكي على kinase يبقى هذا الـ البروتين هيعمل على
+
+133
+00:11:46,150 --> 00:11:52,540
+اللي هو الـ phosphorylation ل other proteinsوهذا
+
+134
+00:11:52,540 --> 00:11:56,260
+فعليًا اللي بيصير ارتباط الـ Insulin مع الـ Alpha
+
+135
+00:11:56,260 --> 00:11:59,140
+-subunit بيعمل confirmation change في الـ Beta
+
+136
+00:11:59,140 --> 00:12:03,940
+-subunits ويؤدي إلى auto phosphorylation لـ Beta
+
+137
+00:12:03,940 --> 00:12:08,800
+-subunits وبالتالي هذا يؤدي إلى recruitment لـ
+
+138
+00:12:08,800 --> 00:12:13,960
+other cytoplasmic proteins to be phosphorylatedالـ
+
+139
+00:12:13,960 --> 00:12:17,320
+Phosphorylation بيستدعى بروتينات أخرى، وهذه
+
+140
+00:12:17,320 --> 00:12:21,220
+البروتينات الأخرى هيصلها Phosphorylation عن طريق
+
+141
+00:12:21,220 --> 00:12:26,400
+اللي هو الـ Active Tyrosine Kinase اللي هو الخاص
+
+142
+00:12:26,400 --> 00:12:31,890
+بالـ Receptor يبقى زي ما قلنا الـ Phosphorylation
+
+143
+00:12:31,890 --> 00:12:37,390
+لـ الـ الـ cytoplasmic domain لـ الـ Beta-subunit
+
+144
+00:12:37,390 --> 00:12:42,190
+بيستدعي بروتينات أخرى زي الـ SHC و بيصلها
+
+145
+00:12:42,190 --> 00:12:47,390
+Phosphorylation و عندنا أيضًا بروتين آخر اللي هو
+
+146
+00:12:47,390 --> 00:12:52,370
+الـ IRS Insulin Receptor Substrate هذه البروتينات
+
+147
+00:12:52,370 --> 00:12:57,660
+بيصلها Phosphorylationوبعد هيك هذه البروتينات
+
+148
+00:12:57,660 --> 00:13:03,780
+بترتبط مع بروتينات أخرى موجودة في الـCytoplasm
+
+149
+00:13:03,780 --> 00:13:12,640
+وبتعمللها activation مرة أخرى طبعا بالونهاية
+
+150
+00:13:12,640 --> 00:13:19,920
+الـCascade هذا عندنا العديد من الـmetabolic
+
+151
+00:13:19,920 --> 00:13:25,340
+pathways اللي طبعا مرتبطة بالأساس بوجود الانشلين
+
+152
+00:13:25,560 --> 00:13:30,340
+ومنها عنا على سبيل المثال الـ cell growth و
+
+153
+00:13:30,340 --> 00:13:34,140
+differentiation في عنا اللي هو الـ protein
+
+154
+00:13:34,140 --> 00:13:37,980
+synthesis في عنا الـ glycogen synthesis في عنا
+
+155
+00:13:37,980 --> 00:13:44,300
+المنع للـ gluconeogenesis وعنا أيضا زيادة الـ
+
+156
+00:13:44,300 --> 00:13:51,490
+lipogenesisأيضًا بالإضافة إلى الـ Translocation
+
+157
+00:13:51,490 --> 00:13:56,970
+اللي بيصير لواحدة من البروتين الـ transporters
+
+158
+00:13:56,970 --> 00:14:01,310
+الخاصة بالجلوكوز الوزيق والجلوت، يعني هذا البروتين
+
+159
+00:14:01,310 --> 00:14:07,030
+بيكون في داخل الـ cytoplasm ومع ارتباط الانسلين
+
+160
+00:14:07,030 --> 00:14:11,110
+بيصير في عندنا Translocation وبيبدأ طبعًا بفعل
+
+161
+00:14:11,110 --> 00:14:18,150
+اللي هو البروتين يسمى AKT يبقى هذا بيؤدي إلى حدوث
+
+162
+00:14:18,150 --> 00:14:22,690
+Translocation للجلوت اللي موجودة كانت في داخل الـ
+
+163
+00:14:22,690 --> 00:14:27,310
+Cytoplasm وارتباطها
+
+164
+00:14:27,310 --> 00:14:33,770
+بالـ Cell Membrane للسماح بأكتر الـ Glucose للدخول
+
+165
+00:14:33,770 --> 00:14:40,430
+إلى الخلية هذه الـ Slider اللي هو شريح للكلام اللي
+
+166
+00:14:40,430 --> 00:14:45,500
+حكيناه بالـ Slider السابق من البروتينات اللي بيصلها
+
+167
+00:14:45,500 --> 00:14:51,040
+activation بسبب ارتباط الانسولين فيها ان الـ
+
+168
+00:14:51,040 --> 00:14:55,540
+Phosphotidylinositol-3-kinase اللي هو ده طبعا
+
+169
+00:14:55,540 --> 00:15:00,940
+البروتين بتكون وفيها growth factor receptor bound
+
+170
+00:15:00,940 --> 00:15:05,720
+البروتين اللي هو GRP2 وهدول الـ two proteins
+
+171
+00:15:05,720 --> 00:15:12,780
+بيلعبوا دور مهم في نقل الـ signal إلى يعني داخل
+
+172
+00:15:13,090 --> 00:15:18,550
+الخلية أيضًا برضه أنه الـ Signaling Pathway آخر
+
+173
+00:15:18,550 --> 00:15:22,370
+اللي برضه مرتبط بارتباط الـ Insulin على الـ
+
+174
+00:15:22,370 --> 00:15:26,530
+Receptors الـ Mitogen Activated Protein كينازي
+
+175
+00:15:26,530 --> 00:15:31,370
+اللي هو الـ MAP كينازي و اللي بيشتغل من خلال ال
+
+176
+00:15:31,370 --> 00:15:39,620
+activation للرأس أيضًا أن الـ PI3 زي ما قلنابسله
+
+177
+00:15:39,620 --> 00:15:45,200
+activation و هو بدوره بيعمل activation لـ AKT و
+
+178
+00:15:45,200 --> 00:15:51,820
+الـ AKT اللي هي بتلعب دور مهم زي ما حكينا في الـ
+
+179
+00:15:51,820 --> 00:15:57,160
+Translocation اللي بده يصير لجلوت Transporter
+
+180
+00:15:57,160 --> 00:16:04,420
+بروتين وهذا الـ AKT بيشتغل من خلال الـ PDK1
+
+181
+00:16:06,190 --> 00:16:12,070
+ال effect اللي هتنتج بالخلايا أو بال tissue اللي
+
+182
+00:16:12,070 --> 00:16:17,390
+هيرتبط فيه ال insulin ممكن يكون فيها بعض الاختلاف
+
+183
+00:16:17,390 --> 00:16:22,090
+يبقى من tissue لآخر ممكن يكون فينا بعض الاختلاف
+
+184
+00:16:22,090 --> 00:16:28,910
+اللي هو ناتج عن ارتباط ال insulin بهذه ال cells
+
+185
+00:16:28,910 --> 00:16:33,790
+على سبيل المثال عندنا enescalatal muscle and
+
+186
+00:16:33,790 --> 00:16:37,680
+adipose tissueالـ AKT تقوم بتحريك  الـ glucose
+
+187
+00:16:37,680 --> 00:16:43,180
+transporter GLUT4 كما
+
+188
+00:16:43,180 --> 00:16:48,160
+قلت،  الـ glucose transporter GLUT4 يكون موجود في
+
+223
+00:19:52,100 --> 00:19:57,120
+الـ Sodium تمامًا، و أيضًا بيعمل على دخول الـ
+
+224
+00:19:57,120 --> 00:20:02,420
+Glucose في نفس الوقت إلى داخل الخلايا، زي الخلايا
+
+225
+00:20:02,420 --> 00:20:04,860
+الموجودة بالأمعاء، على سبيل المثال، هو الـ
+
+226
+00:20:04,860 --> 00:20:08,940
+Enterocytes، و الذي يكون عن طريق ما قلته
+
+227
+00:20:08,940 --> 00:20:13,720
+بيصير فيه أنه absorption للـ Glucose و دخوله إلى
+
+228
+00:20:13,720 --> 00:20:17,740
+داخل خلايا الأمعاء، اللي هو الـ Enterocytes
+
+229
+00:20:23,600 --> 00:20:28,700
+الـ SGLT تدفع تحرير الجلوكوز و الجالاكتوز من اللمع الصغير
+
+230
+00:20:28,700 --> 00:20:36,440
+والتعادل من الدم، في اللمع، يبقى كمان الـ SGLT
+
+231
+00:20:36,440 --> 00:20:41,420
+برضه بتلعب دور في عملية الـ Reabsorption مرة أخرى
+
+232
+00:20:41,420 --> 00:20:44,900
+لجلوكوز، بعد ما تصير عندنا اللي هو عملية الـ
+
+233
+00:20:44,900 --> 00:20:50,840
+filtration، و بيدخل الجلوكوز ضمن الفلترات، كما نحن
+
+234
+00:20:50,840 --> 00:20:54,240
+عارفين، في أول جزء من الـ tubules اللي هو عندنا الـ
+
+235
+00:20:54,240 --> 00:20:57,140
+proximal convoluted tubules، بيصير في عندنا
+
+236
+00:20:57,140 --> 00:21:03,620
+Reabsorption للكمية الأكبر أو لأغلب الـ Glucose
+
+237
+00:21:03,620 --> 00:21:08,340
+الموجود في الفلترات، و الذي يلعب دور في هذه العملية
+
+238
+00:21:08,340 --> 00:21:12,540
+الـ Reabsorption، هو برضه الـ SGL2
+
+239
+00:21:12,540 --> 00:21:17,900
+بروتينز، هذا النوع
+
+240
+00:21:17,900 --> 00:21:22,220
+الثاني من الـ Transporters هو اللي هو الـ Glut
+
+241
+00:21:22,220 --> 00:21:26,460
+family of membrane proteins that are encoded by
+
+242
+00:21:26,460 --> 00:21:38,660
+the SLC2 genes، وعندنا عدد يعني من هذه الـ proteins من
+
+243
+00:21:38,660 --> 00:21:44,940
+اللي هو Glut 1 لغاية Glut 14، وتم تسميتهم يعني
+
+244
+00:21:44,940 --> 00:21:49,920
+بناءً على وقت اكتشافهم، تمام؟ و Glut 1 يعني هو
+
+245
+00:21:49,920 --> 00:21:56,900
+هذا أول protein تم اكتشافه في هذه العائلة، وتم
+
+246
+00:21:56,900 --> 00:22:01,760
+تقسيم هذه البروتينات إلى ثلاثة أقسام بعد ذلك، زي ما
+
+247
+00:22:01,760 --> 00:22:04,000
+احنا شايفين، في عندنا class one، في عندنا class
+
+248
+00:22:04,000 --> 00:22:08,400
+two، وفي عندنا اللي هو class three، هذه التقسيمة
+
+249
+00:22:08,400 --> 00:22:13,400
+تمت بناءً على الـ sequence similarities، وبناءً
+
+250
+00:22:13,400 --> 00:22:19,380
+على اللي هو التشابه في الخصائص للبروتينات المختلفة
+
+251
+00:22:22,100 --> 00:22:26,260
+البروتينات المختلفة يعني موجودة، زي ما هو واضح حاليًا
+
+252
+00:22:26,260 --> 00:22:30,680
+من خلال الـ Table، فيه tissues مختلفة، يعني أن الـ
+
+253
+00:22:30,680 --> 00:22:33,660
+Glut1، على سبيل المثال، اللي هو موجود بالـ
+
+254
+00:22:33,660 --> 00:22:37,800
+Erythrocyte، الـ Brain، Blood-Brain Barrier، Fetal
+
+255
+00:22:37,800 --> 00:22:41,300
+Tissues، Glut2 موجود في الـ Liver و Beta Cells of
+
+256
+00:22:41,300 --> 00:22:45,200
+the Pancreas، Glut4، Skeletal Muscle و Cardiac
+
+257
+00:22:45,200 --> 00:22:48,480
+Muscle، تمام، يبقى عندنا الأنواع المختلفة من هذه
+
+258
+00:22:48,480 --> 00:22:52,860
+البروتينات موجودة في tissues مختلفة، وممكن نلاقي أكثر من
+
+259
+00:22:52,860 --> 00:23:01,270
+نوع موجود في نفس الـ tissue، وبعض هذه الأنواع من
+
+260
+00:23:01,270 --> 00:23:07,550
+الـ protein اللي هو الـ Glut بيلعب دور غير اللي
+
+261
+00:23:07,550 --> 00:23:13,530
+هو موضوع نقل لـ Glucose، زي أن الـ Glut 9 اللي هو
+
+262
+00:23:13,530 --> 00:23:18,300
+transports Urea، عندنا على سبيل المثال اللي هو "Glut
+
+263
+00:23:18,300 --> 00:23:24,260
+-13"، هذا transporter  myo-inositol، اللي هو
+
+264
+00:23:24,260 --> 00:23:29,000
+موجود في يعني tissues زي الـ Brain والـ adipose
+
+265
+00:23:29,000 --> 00:23:35,200
+tissue، يبقى أغلب هذه البروتينات مسئولة عن نقل الـ
+
+266
+00:23:35,200 --> 00:23:41,000
+Glucose، لكن عندنا زي ما شفنا البعض منها بينقل
+
+267
+00:23:41,000 --> 00:23:42,360
+مواد أخرى
+
+268
+00:23:46,070 --> 00:23:49,510
+هذه transporters تم تسميتها من Glut-1 إلى Glut-14
+
+269
+00:23:49,510 --> 00:23:55,390
+بناءً على ترتيب اكتشافها، 11 منها
+
+270
+00:23:55,390 --> 00:24:02,410
+أُظهر أنها تنقل الجلوكوز، وكذلك الكثير
+
+271
+00:24:02,410 --> 00:24:07,470
+منها ينقل أيضًا سكريات مثل Galactose, Fructose,
+
+272
+00:24:07,930 --> 00:24:14,310
+Mannose و Xylose، كمثال على هذه البروتينات اللي
+
+273
+00:24:14,310 --> 00:24:19,310
+بتعمل على نقل الجلوكوز، لو حكينا على Glut4، when
+
+274
+00:24:19,310 --> 00:24:23,150
+circulating insulin concentrations are low, most of
+
+275
+00:24:23,150 --> 00:24:26,630
+the Glut4 is localized in intracellular
+
+276
+00:24:26,630 --> 00:24:30,810
+compartments، يبقى لما نكون عندنا مستويات الانسولين
+
+277
+00:24:30,810 --> 00:24:35,830
+منخفضة، بمعنى أنه عندنا الـ glucose
+
+278
+00:24:35,830 --> 00:24:40,020
+concentration في الدم ضمن الـ Reference
+
+279
+00:24:40,020 --> 00:24:43,860
+Interval أو ضمن يعني الـ Reference Range، يبقى
+
+280
+00:24:43,860 --> 00:24:47,400
+بيكون أن الـ Glucose Transporter اللي هو مثلًا
+
+281
+00:24:47,400 --> 00:24:53,240
+مثلًا Glut4، بيكون موجود في داخل الـ Cytoplasm في
+
+282
+00:24:53,240 --> 00:24:57,420
+داخل الخلية، بيكون مش موجود على الـ cell membrane
+
+283
+00:24:57,420 --> 00:25:00,960
+يبقى Localized in Intracellular compartments and
+
+284
+00:25:00,960 --> 00:25:08,310
+is inactive، لكن بعد ما الإنسان بيتناول الطعام، و
+
+285
+00:25:08,310 --> 00:25:12,330
+اللي هو الموجود فيه carbohydrates، يبقى بيبدأ يصير
+
+286
+00:25:12,330 --> 00:25:19,410
+فينا ارتفاع في مستوى الانسولين، و زي ما شفنا بالـ
+
+287
+00:25:19,410 --> 00:25:24,570
+figure الخاص بالميكانزم، من ضمن الـ mechanisms اللي
+
+288
+00:25:24,570 --> 00:25:30,910
+بيقوم فيها الانسولين هو الـ Activation لـ AKT، وهو
+
+289
+00:25:30,910 --> 00:25:37,410
+مسؤول عن حدوث Translocation لـ Glut4 للـ plasma membrane
+
+290
+00:25:37,410 --> 00:25:42,630
+وبالتالي دخول كميات أكبر من الجلوكوز into skeletal
+
+291
+00:25:42,630 --> 00:25:50,510
+muscle and fat، الانسولين يدفع الجلوكوز للتواصل إلى
+
+292
+00:25:50,510 --> 00:25:54,250
+الـ muscle، يكون مُفارقًا في الـ Type 2
+
+293
+00:25:54,250 --> 00:25:58,450
+Diabetes Mellitus، ولكن الميكانيزم لم يتم إصلاحه،
+
+294
+00:25:58,450 --> 00:26:02,430
+لهذا من المشكلات الموجودة في الناس اللي عندهم Type
+
+295
+00:26:02,430 --> 00:26:05,860
+2 Diabetes Mellitus، أنه عندنا الـ Insulin
+
+296
+00:26:05,860 --> 00:26:09,780
+Stimulated Glucose Transport، اللي هو زي ما حكينا
+
+297
+00:26:09,780 --> 00:26:12,360
+أنه الـ Translocation اللي بتصير للـ
+
+298
+00:26:12,360 --> 00:26:15,900
+Transporters، و اللي بتسمح بدخول كميات كبيرة من الـ
+
+299
+00:26:15,900 --> 00:26:20,880
+Glucose، هذه بيصير فيها مشكلة عند الناس اللي عندهم
+
+300
+00:26:20,880 --> 00:26:24,520
+Type 2 Diabetes Mellitus، وهذا اللي بيؤدي إلى طبعًا
+
+301
+00:26:24,520 --> 00:26:28,880
+الـ Hyperglycemia، و الارتفاع اللي هو في الـ Glucose
+
+302
+00:26:28,880 --> 00:26:33,180
+الكبير اللي بيصير بعد تناول الوجبات
+
+303
+00:26:36,140 --> 00:26:40,380
+الهرمون الآخر الأساسي اللي بيلعب دور في عملية الـ
+
+304
+00:26:40,380 --> 00:26:46,460
+Regulation للجلوكوز، هو الـ Glucagon، هو عبارة عن
+
+305
+00:26:46,460 --> 00:26:52,320
+29-Amino Acid Polypeptide، وبيتم إفرازه من خلايا
+
+306
+00:26:52,320 --> 00:26:56,820
+تسمى الـ Alpha cells، وهذه موجودة في الـ Islets of
+
+307
+00:26:56,820 --> 00:27:04,370
+Langerhans في البنكرياس، الـ Glucagon أيضًا يُفرز
+
+308
+00:27:04,370 --> 00:27:10,530
+أو بيتم تصنيعه بـ cellosynthesis في صورة غير فعالة، Pro
+
+309
+00:27:10,530 --> 00:27:18,140
+-Glucagon، وبعد ذلك بيصير فيه تفعيل لهذا
+
+310
+00:27:18,140 --> 00:27:22,640
+البروتين، عن طريق الـ Pro-Hormone Convertase-II
+
+311
+00:27:22,640 --> 00:27:27,860
+اللي بيقوم بتقسيم جزء من الـ Pro-Glucagon، وبيتحول
+
+312
+00:27:27,860 --> 00:27:33,100
+إلى Active-Glucagon، Major target organ for
+
+313
+00:27:33,100 --> 00:27:37,960
+glucagon is the liver، واحنا عارفين إنه الـ Glucagon
+
+314
+00:27:37,960 --> 00:27:43,600
+عبارة عن hyperglycemic agent، يبقى هو بيعمل على رفع
+
+315
+00:27:43,600 --> 00:27:53,280
+مستوى الجلوكوز في الدم، في حالة الصيام، يبقى
+
+316
+00:27:53,280 --> 00:27:57,660
+في الكبد، الـ glucagon بيرتبط لنوع من الـ
+
+317
+00:27:57,660 --> 00:28:01,660
+receptors اللي يسمى G-protein coupled receptor
+
+318
+00:28:03,400 --> 00:28:08,720
+الذي يُعبر عنه بشكلٍ عالٍ في الكبد، والقلب، وعلى أقل
+
+319
+00:28:08,720 --> 00:28:14,400
+مدى في أعضاء أخرى، مثل القولون، البنكرياس، و الدماغ
+
+320
+00:28:14,400 --> 00:28:20,420
+العقلي. الجلوكاجون يُحفز تحويل الجلوكوز في الكبد
+
+321
+00:28:20,880 --> 00:28:24,840
+بشكلٍ رئيسي عن طريق Glucogenolysis، هذه العمليات
+
+322
+00:28:24,840 --> 00:28:28,820
+اللي بيشتغل من خلالها الجلوكاجون واللي بيعمل على
+
+323
+00:28:28,820 --> 00:28:32,500
+رفع مستوى الجلوكوز في الدم، هي العملية الأولى
+
+324
+00:28:32,500 --> 00:28:35,660
+Glucogenolysis، اللي هو عملية التكسير اللي بتصير
+
+325
+00:28:35,660 --> 00:28:42,400
+للـ Glycogen اللي تم تخزينه، وأيضًا يبقى إنتاج
+
+326
+00:28:42,400 --> 00:28:48,180
+لجلوكوز من اللي هو الـ Glycogen stores، وأيضًا برضه
+
+327
+00:28:48,180 --> 00:28:52,090
+فيه Gluconeogenesis، اللي هو production of
+
+328
+00:28:52,090 --> 00:28:56,470
+glucose from non-carbohydrate sources، بهذه العملية برضه
+
+329
+00:28:56,470 --> 00:29:03,670
+العملية بتتم بـ activation، وبرضه في نفس الوقت هنا
+
+330
+00:29:03,670 --> 00:29:07,890
+عملية اللي هو التخزين للجلوكوز بتكون بـ inhibition
+
+331
+00:29:07,890 --> 00:29:11,690
+بهذه العملية glucogenesis بتكون بـ inhibition، لأن احنا هنا
+
+332
+00:29:11,690 --> 00:29:17,130
+بحاجة إلى رفع مستوى الجلوكوز في الدم
+
+333
+00:29:19,720 --> 00:29:23,220
+الـ Glucagon secretion is regulated primarily by
+
+334
+00:29:23,220 --> 00:29:27,420
+plasma glucose concentrations، بيحسب مستوى
+
+335
+00:29:27,420 --> 00:29:31,700
+الجلوكوز في الدم، إذا انخفض مستوى الجلوكوز في الدم
+
+336
+00:29:31,700 --> 00:29:37,460
+عن 70، يكون هنا بيصير في عندنا stimulation للـ
+
+337
+00:29:37,460 --> 00:29:41,160
+alpha cells في البنكرياس، عشان تعمل release
+
+338
+00:29:41,160 --> 00:29:42,580
+للجلوكاجون
+
+339
+00:29:44,380 --> 00:29:47,700
+with low and high plasma glucose being stimulatory
+
+340
+00:29:47,700 --> 00:29:52,220
+and inhibitory respectively، ولما يكون عندنا الـ
+
+341
+00:29:52,220 --> 00:29:56,360
+plasma glucose منخفضة، يبقى ده بيعمل stimulation لـ
+
+342
+00:29:56,360 --> 00:30:01,480
+الـ release of glucagon، لكن لو كان عندنا الـ plasma
+
+343
+00:30:01,480 --> 00:30:06,190
+glucose مرتفعة، معناته حيصير فيه في هذه
+
+344
+00:30:06,190 --> 00:30:10,250
+الحالة Release للـ Insulin، و اللي هيعمل Inhibition
+
+345
+00:30:10,250 --> 00:30:15,030
+على الـ Alpha Cells، وبالتالي هيقلل من إفراز
+
+346
+00:30:15,030 --> 00:30:19,590
+الـ Glucagon، Long-standing diabetes mellitus impairs
+
+347
+00:30:19,590 --> 00:30:24,110
+the glucagon response to hypoglycemia، وهذه مشكلة
+
+348
+00:30:24,110 --> 00:30:30,790
+من المشكلات اللي ممكن تكون موجودة عند الناس اللي
+
+349
+00:30:30,790 --> 00:30:37,630
+عندهم diabetes، واللي بتؤدي إلى حدوث Hypoglycemia
+
+350
+00:30:37,630 --> 00:30:42,810
+يبقى الـ Longstanding Diabetes Mellitus بيأثر على
+
+351
+00:30:42,810 --> 00:30:49,010
+الـ Glucagon response to Hypoglycemia، يبقى المفروض
+
+352
+00:30:49,010 --> 00:30:52,310
+إحنا زي ما قلنا، إنه لو صار فينا انخفاض للجلوكوز عن
+
+353
+00:30:52,310 --> 00:30:56,210
+70 مليجرام per deciliter، يبقى مباشرة المفروض يصير
+
+354
+00:30:56,210 --> 00:31:01,150
+فيه release للـ Glucagon، لكن المشكلة إنه الإصابة
+
+355
+00:31:01,150 --> 00:31:05,430
+لفترة طويلة بـ Diabetes Mellitus، هذا هيأثر على
+
+356
+00:31:05,430 --> 00:31:10,910
+هذه العملية، وبالتالي هذا هيزيد من الـ Hypoglycemic
+
+357
+00:31:10,910 --> 00:31:12,050
+episodes
+
+358
+00:31:15,550 --> 00:31:19,530
+بما يتعلق بالناس اللي عندهم Type 1 diabetes
+
+359
+00:31:19,530 --> 00:31:27,410
+mellitus، ومن خلال الأبحاث المختلفة، وجد أن اللي
+
+360
+00:31:27,410 --> 00:31:29,770
+هو الـ response أو الـ glucagon response
+
+361
+00:31:29,770 --> 00:31:37,130
+لـ Hypoglycemia ممكن يحدث في فترة قصيرة، للناس اللي
+
+362
+00:31:37,130 --> 00:31:40,880
+عندهم Type 1 diabetes mellitus، طبعًا، يبقى ممكن
+
+363
+00:31:40,880 --> 00:31:46,300
+هذه تحدث في فترة قصيرة، يعني ممكن تحدث في فترة اللي
+
+364
+00:31:46,300 --> 00:31:52,380
+لا تتجاوز ممكن شهر أو شهرين، ممكن يصير في عندنا
+
+365
+00:31:52,380 --> 00:31:58,340
+فيه مشكلة الـ Glucagon، أو اللي هو انخفاض في
+
+366
+00:31:58,340 --> 00:32:02,520
+الـ Glucagon response to hypoglycemia، بالتالي هذا
+
+367
+00:32:02,520 --> 00:32:09,680
+قلنا إنه بيعمل ممكن مشكلة، وممكن يزيد من اللي هو
+
+368
+00:32:09,680 --> 00:32:14,360
+حدوث الـ hypoglycemia episodes، و هؤلاء المرضى
+
+369
+00:32:14,360 --> 00:32:19,340
+Stress، exercise، و amino acids induce glucagon
+
+370
+00:32:19,340 --> 00:32:24,040
+release، هذه كلها أكيد بتحتاج إلى ارتفاع في
+
+371
+00:32:24,040 --> 00:32:29,840
+مستوى الجلوكوز، وبالتالي كلها بتعمل على زيادة الـ
+
+372
+00:32:29,840 --> 00:32:33,940
+release of glucagon، طيب الـ stress، الـ exercise، نحن
+
+373
+00:32:33,940 --> 00:32:37,300
+متفقين أن هذه بتحتاج إلى الجلوكوز
+
+374
+00:32:37,300 --> 00:32:40,140
+وبالتالي بدنا Glucagon release، طيب الـ amino acids
+
+375
+00:32:40,140 --> 00:32:45,900
+يعني المفروض الـ amino acids، أمتى بتصير موجودة في
+
+376
+00:32:45,900 --> 00:32:48,240
+الدم، أو تزيد الـ concentration في الدم، بعد تناول
+
+377
+00:32:48,240 --> 00:32:52,980
+وجبة، طيب ليش بقى هنا، الوجبة بده يرتفع عندنا
+
+378
+00:32:52,980 --> 00:32:56,120
+الـ Glucagon؟ مع أنه المفروض أنه يصير في عندنا
+
+379
+00:32:56,120 --> 00:33:01,400
+انخفاض، واللي يرتفع هو الـ Insulin، وفعليًا
+
+380
+00:33:01,400 --> 00:33:07,740
+الـ Insulin بيرتفع، تمام؟ لكن برضه الـ Amino Acids
+
+381
+00:33:07,740 --> 00:33:15,570
+بتعمل على رفع الـ Glucagon، وهذه العملية يعني فيها
+
+382
+00:33:15,570 --> 00:33:21,290
+توازن، ومرتبطة بـ glucose concentration، ومرتبطة
+
+383
+00:33:21,290 --> 00:33:27,570
+بالـ Insulin أيضًا، لأن احنا عندنا الجسم الآن بعد
+
+384
+00:33:27,570 --> 00:33:31,870
+تناول وجبة، صار فينا ارتفاع في الـ Amino Acids، صار
+
+385
+00:33:31,870 --> 00:33:36,350
+فينا ارتفاع في الجلوكوز، صار فينا إفراز للانسولين
+
+386
+00:33:36,350 --> 00:33:40,210
+والانسولين بدأ يخفض من مستويات الجلوكوز بالدم، يبقى
+
+387
+00:33:40,210 --> 00:33:44,550
+احنا ما نقدرش أن نوقف عمل الـ Alpha cells
+
+388
+00:33:44,550 --> 00:33:48,630
+وما يكونش فينا Glucagon موجود في الدم، لأن هذا ممكن
+
+389
+00:33:48,630 --> 00:33:52,750
+يؤدي إلى حدوث Hypoglycemia، يعني هذه العملية بيصير
+
+390
+00:33:52,750 --> 00:33:57,110
+فيها توازن، وبيبدأ يصير فينا يعني Release لكميات
+
+391
+00:33:57,520 --> 00:34:02,580
+بسيطة من الـ Glucagon، عشان يمنع من حدوث
+
+392
+00:34:02,580 --> 00:34:09,040
+الـ Hypoglycemia، الانسولين يثبط إطلاق الـ Glucagon من
+
+393
+00:34:09,040 --> 00:34:13,360
+البنكرياس، ويقلل إطلاق الـ Glucagon في الكبد.
+
+394
+00:34:13,360 --> 00:34:17,920
+بمجرد إضافة بيوسنتيزاتها زي ما حكينا قبل شوية،
+
+395
+00:34:17,920 --> 00:34:22,000
+قلنا إن الانسولين بيعمل Inhibition على الـ Alpha
+
+396
+00:34:22,000 --> 00:34:29,090
+cells، وبالتالي بيمنع الـ glucagon release، وهذا
+
+397
+00:34:29,090 --> 00:34:33,490
+بيكون عن طريق اللي هو خفض الـ glucagon gene
+
+398
+00:34:33,490 --> 00:34:41,110
+expression في خلايا الـ alpha cells، increase
+
+399
+00:34:41,110 --> 00:34:44,350
+in glucagon concentrations secondary to insulin
+
+400
+00:34:44,350 --> 00:34:47,
+
+445
+00:38:26,930 --> 00:38:34,350
+الـ GLP-1 موجودة في أماكن مختلفة، ومش فقط في البنكرياس
+
+446
+00:38:34,350 --> 00:38:40,550
+يبقى widely expressed وبتلعب دور مهم في
+
+447
+00:38:40,550 --> 00:38:45,210
+عملية الـ regulation لتركيز الجلوكوز من
+
+448
+00:38:45,210 --> 00:38:51,670
+خلال ميكانيزمز مختلفة، ومن ضمن هذه الميكانيزمز أن
+
+449
+00:38:51,670 --> 00:38:55,930
+هناك inhibition of glucose production and food
+
+450
+00:38:55,930 --> 00:39:02,500
+intake. تمام، يبقى من ضمن اللي هو الـ .. الـ
+
+451
+00:39:02,500 --> 00:39:04,560
+mechanisms، طبعا زي ما حكيّت أنا سابقا، لإنه بيزيد
+
+452
+00:39:04,560 --> 00:39:10,780
+إفراز الإنسولين، لكن برضه بيمنع من ال glucose
+
+453
+00:39:10,780 --> 00:39:15,580
+production وبيمنع برضه أو بيقلل ممكن من امتصاص glucose
+
+454
+00:39:15,580 --> 00:39:22,080
+وبالتالي يقلل من food intake، عشان هيك الـ GLP-1
+
+455
+00:39:22,080 --> 00:39:26,020
+analogues are generating interest in the treatment
+
+456
+00:39:26,020 --> 00:39:31,800
+of type 2 diabetes. في عندنا أدوية، وهذه عبارة عن
+
+457
+00:39:31,800 --> 00:39:37,800
+GLP-1 Analogs. تمام، بيغير أنه ممكن تعمل release
+
+458
+00:39:37,800 --> 00:39:41,920
+للإنسولين، لكن برضه بتقلل من إنتاج الجلوكوز
+
+459
+00:39:41,920 --> 00:39:50,240
+وأيضا بتقلل من امتصاصه. وفي أربعة أدوية يعني تمّ
+
+460
+00:39:50,240 --> 00:39:55,240
+إنتاجها، وحصلت على الـ Approval من الـ Food and
+
+461
+00:39:55,240 --> 00:40:00,580
+Drug Administration لإستعمالها مع مرضى Type 2
+
+462
+00:40:00,580 --> 00:40:02,440
+Diabetes Mellitus
diff --git a/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/wNcigeivKdA_postprocess.srt b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/wNcigeivKdA_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..81ac8b46508dcf95c5adf1eb124a52b91e4fecc1
--- /dev/null
+++ b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/wNcigeivKdA_postprocess.srt
@@ -0,0 +1,1848 @@
+1
+00:00:01,840 --> 00:00:06,080
+بسم الله الرحمن الرحيم نستكمل مع محاضرة diabetes
+
+2
+00:00:06,080 --> 00:00:12,940
+mellitus ووصلنا لغاية ال insulin و ال antibodies
+
+3
+00:00:12,940 --> 00:00:14,260
+to insulin
+
+4
+00:00:16,690 --> 00:00:22,170
+الجسم ممكن ينتج antibody against the exogenous
+
+5
+00:00:22,170 --> 00:00:29,850
+انسولين يعني الناس اللي بتعالجوا بالانسولين ممكن
+
+6
+00:00:29,850 --> 00:00:34,950
+يصير في antibodies أو الجسم ينتج antibodies ضد هذا
+
+7
+00:00:34,950 --> 00:00:40,550
+الانسولين وهذا بنطلق عليه exogenous insulin
+
+8
+00:00:40,550 --> 00:00:42,470
+antibody syndrome
+
+9
+00:00:44,970 --> 00:00:48,690
+الـ these antibodies are usually present at low
+
+10
+00:00:48,690 --> 00:00:52,410
+titers يبقى ال concentration لل antibodies هذي
+
+11
+00:00:52,410 --> 00:00:59,230
+بتكون قليلة ويعني مابيكونش في عنا أي نتائج يعني
+
+12
+00:00:59,230 --> 00:01:05,350
+عكسية on real .. real occasions high titers of
+
+13
+00:01:05,350 --> 00:01:08,850
+insulin antibodies may cause insulin resistance
+
+14
+00:01:10,760 --> 00:01:17,380
+وهذا بيصير بشكل خاص في الناس اللي عندهم type 2
+
+15
+00:01:17,380 --> 00:01:21,160
+diabetes mellitus و اللي يعني بالمراحل متقدمة من
+
+16
+00:01:21,160 --> 00:01:29,600
+المرض و اللي بدوا ياخدوا insulin ضمن العلاج يبقى
+
+17
+00:01:29,600 --> 00:01:34,100
+بهذه الحالة ممكن يصير فينا ارتفاع في ال
+
+18
+00:01:34,100 --> 00:01:40,730
+concentrations لل insulin antibodiesو هذا الارتفاع
+
+19
+00:01:40,730 --> 00:01:44,890
+سيؤدي إلى insulin resistance
+
+20
+00:01:46,610 --> 00:01:50,570
+كيف يتم التعامل مع هدول المرضى؟ فيه أنه several
+
+21
+00:01:50,570 --> 00:01:54,750
+therapeutic approaches for treating these patients
+
+22
+00:01:54,750 --> 00:01:58,110
+ومن ضمن ال approaches أنه يصير فيه double
+
+23
+00:01:58,110 --> 00:02:04,670
+filtration بلازمافوريس أو يصير فيه plasma exchange
+
+24
+00:02:04,670 --> 00:02:11,110
+لمدة two weeks بالإضافة لـأعطاه هدول المرضى
+
+25
+00:02:11,110 --> 00:02:17,630
+prednisolone اللي هو synthetic hydrocortisone وهذا
+
+26
+00:02:17,630 --> 00:02:21,350
+طبعا اللي هو هيعمل على يعني تقليل ال immune
+
+27
+00:02:21,350 --> 00:02:23,030
+response
+
+28
+00:02:24,740 --> 00:02:29,660
+أيضا في هذه الحالات انه يعني يضل فينا متابع ويعني
+
+29
+00:02:29,660 --> 00:02:35,540
+يتم عمل ال quantitative estimate لإن ال
+
+30
+00:02:35,540 --> 00:02:39,300
+concentration of the circulating insulin
+
+31
+00:02:39,300 --> 00:02:42,980
+antibodies does not appear to be of significant
+
+32
+00:02:42,980 --> 00:02:46,940
+benefit يعني مش هيفيدكتير ما زال عارفنا أنه في
+
+33
+00:02:46,940 --> 00:02:51,100
+عندنا antibodies و ال antibodies هذه يعني إلها
+
+34
+00:02:51,100 --> 00:02:54,240
+مفعول
+
+35
+00:02:54,240 --> 00:02:58,100
+أو ممكن .. ممكن تزيد من ال insulin resistance يبقى
+
+36
+00:02:58,100 --> 00:03:02,680
+بهذه الحالة زي ما قلنا بدنا اللي هو يعني يكون في
+
+37
+00:03:02,680 --> 00:03:08,300
+عندنا therapeutic approach و يتم التعامل مع المريض
+
+38
+00:03:08,300 --> 00:03:11,240
+من خلال اللي ذكرناه
+
+39
+00:03:13,520 --> 00:03:17,700
+التحسين في صحيحة الإنسولين الحيواني وإنسولين
+
+40
+00:03:17,700 --> 00:03:22,540
+الحيواني المتوسط قد أقل، ولكن ليس تقليلاً عن إنتاج
+
+41
+00:03:22,540 --> 00:03:29,320
+الإنسولين الحيواني يبقى مع الإنتاج للإنسولين
+
+42
+00:03:29,320 --> 00:03:33,680
+الحيواني وطبعاً يعني صار في ان اعتماد أقل على
+
+43
+00:03:33,680 --> 00:03:38,800
+الإنسولين الحيواني والصحيحة اللي بتصير درجة عالية
+
+44
+00:03:38,800 --> 00:03:45,370
+للإنسولين هذه قللت بشكل كبيرمن اللي هو ال
+
+45
+00:03:45,370 --> 00:03:49,130
+antibodies لـ
+
+46
+00:03:49,130 --> 00:03:53,490
+exogenous insulin لكن حتى مع ال purification
+
+47
+00:03:53,490 --> 00:03:59,990
+العالي و حتى مع الاستخدام لـ recombinant insulin
+
+48
+00:03:59,990 --> 00:04:04,770
+إلا أنه برضه يعني في ممكن يصير إنتاج ل antibodies
+
+49
+00:04:04,770 --> 00:04:12,820
+against ال exogenous insulinالاستخدام ليه يعني
+
+50
+00:04:12,820 --> 00:04:19,180
+ممكن نقول ال less invasive يعني ways او delivery
+
+51
+00:04:19,180 --> 00:04:27,940
+system لأ ال insulin للأسف هذه زادت من إنتاج ال
+
+52
+00:04:27,940 --> 00:04:33,110
+antibodies ضد ال exogenous insulinيبقى عندنا زي
+
+53
+00:04:33,110 --> 00:04:35,850
+اللي هو ال continuous subcutaneous insulin
+
+54
+00:04:35,850 --> 00:04:42,810
+infusion أو أيضا في اللي هو ال inhaled insulin has
+
+55
+00:04:42,810 --> 00:04:45,770
+resulted in significantly increased concentrations
+
+56
+00:04:45,770 --> 00:04:48,250
+of insulin antibodies
+
+57
+00:04:51,430 --> 00:04:54,630
+Antibodies to insulin really develop in patients
+
+58
+00:04:54,630 --> 00:04:58,770
+who have not received exogenous insulin يبقى
+
+59
+00:04:58,770 --> 00:05:03,870
+المشكلة الأساسية هو بالExogenous insulin يبقى لما
+
+60
+00:05:03,870 --> 00:05:08,030
+يصير في administration لExogenous insulin ممكن
+
+61
+00:05:08,030 --> 00:05:12,030
+تبدأ تتكون Antibodies ضد الانسلين
+
+62
+00:05:15,260 --> 00:05:19,820
+بما يتعلق بالتوصيات طيب هل يصير فيانا فحص مثلا
+
+63
+00:05:19,820 --> 00:05:26,120
+بشكل روتيني لناس اللي عندهم يعني diabetes و
+
+64
+00:05:26,120 --> 00:05:32,500
+بنعطيهم exogenous insulin أو لأ؟ يعني من التوصيات
+
+65
+00:05:32,500 --> 00:05:40,120
+أنه مايصيرش فيه يعني routine يعني quantitation أو
+
+66
+00:05:40,120 --> 00:05:45,670
+measurement لال insulinولكن ليس هناك اثارة لإدارة
+
+67
+00:05:45,670 --> 00:05:50,090
+استخدام الانسلين للتجارب للطبيعي للطبيعي للطيابين
+
+68
+00:05:50,090 --> 00:05:51,690
+اللي بيبتس
+
+69
+00:05:54,020 --> 00:05:58,740
+طبعا زي ما قولنا إنه من المشكلات اللي ممكن تنتج عن
+
+70
+00:05:58,740 --> 00:06:03,760
+وجود ال antibodies هذه وارتباطها مع الانسلين هو
+
+71
+00:06:03,760 --> 00:06:08,920
+حدوث الانسلين resistance وبالتالي هذا هيؤدي إلى
+
+72
+00:06:08,920 --> 00:06:16,350
+ارتفاع في ال postprandial blood glucoseتمام، لأن
+
+73
+00:06:16,350 --> 00:06:20,470
+الـ Antibodies مرتبط للإنسلين، وبالتالي الإنسلين
+
+74
+00:06:20,470 --> 00:06:25,010
+مش هيقوم بعمله، والمشكلة التانية المتعلقة برضه
+
+75
+00:06:25,010 --> 00:06:30,530
+بهذا الأمر، إن ارتباط الـ Antibodies بالإنسلين
+
+76
+00:06:30,530 --> 00:06:34,870
+reversibleلما بيجي ال antibody مش هيضال مرتبط لو
+
+77
+00:06:34,870 --> 00:06:40,070
+تغيرت الظروف ممكن يفك الإرتباط بين ال insulin و
+
+78
+00:06:40,070 --> 00:06:43,470
+بين ال antibody وبالتالي هذا ممكن يزيد من ال
+
+79
+00:06:43,470 --> 00:06:48,410
+insulin concentration اللي موجودة بالدم وهذا اللي
+
+80
+00:06:48,410 --> 00:06:54,430
+ممكن يصير at night التغير فيهالـ pH at night ممكن
+
+81
+00:06:54,430 --> 00:06:59,670
+يعمل dissociation بين الإنسلين وبين الـ antibody
+
+82
+00:06:59,670 --> 00:07:04,930
+اللي كان مرتبط معاه وبالتالي يزيد من الـ ال
+
+83
+00:07:04,930 --> 00:07:08,690
+concentration للإنسلين وبالتالي ممكن يؤدي إلى
+
+84
+00:07:08,690 --> 00:07:14,490
+hypoglycemia أنها مشكلة تانية بتتعلق بال
+
+85
+00:07:14,490 --> 00:07:18,770
+antibodies هو إنتاج antibodies ضد الإنسلين
+
+86
+00:07:18,770 --> 00:07:27,650
+receptorوفي هذه الحالة أنه ممكن ينبج مشكلتين ال
+
+87
+00:07:27,650 --> 00:07:32,190
+antibodies هذه اللي هترتبط مع ال receptor ممكن
+
+88
+00:07:32,190 --> 00:07:38,350
+تشتغل ك antagonist وإذا اشتغلت ك antagonist معناه
+
+89
+00:07:38,350 --> 00:07:41,690
+طبعا هيصير فيه competition بينها و بين ال ال
+
+90
+00:07:41,690 --> 00:07:44,670
+insulin و هي هترتبط مع ال receptor و تمنع من
+
+91
+00:07:44,670 --> 00:07:51,820
+ارتباطالانسولين و هتؤدي الى حدوث hyperglycemia
+
+92
+00:07:51,820 --> 00:07:57,300
+وهذا اللى بيشوفوه فى حالات ال patients with
+
+93
+00:07:57,300 --> 00:08:05,080
+acanthosis negligens اللى بيكون فى اللى هو يعني زى
+
+94
+00:08:05,080 --> 00:08:10,960
+epidermal skin cells begin to reproduce rapidly
+
+95
+00:08:10,960 --> 00:08:18,040
+فبصير فى تكاثر لخلايا بشكل كبيرو هذا بيعمل اللي هو
+
+96
+00:08:18,040 --> 00:08:23,320
+ال skin growth و بيبين اللي هو بالشكل زي اللي هو
+
+97
+00:08:23,320 --> 00:08:29,490
+الصورة دي سواء تحت القبض أو على اللي هو الرقبةوهذا
+
+98
+00:08:29,490 --> 00:08:32,850
+زي ما قلنا بيكون بسبب أنه في عندي antibodies ضد ال
+
+99
+00:08:32,850 --> 00:08:40,110
+receptors وهذا بيمنع من ارتباط ال .. ال insulin
+
+100
+00:08:40,110 --> 00:08:45,890
+وبي .. هذا بيقدر إلى رفع مستويات ال insulin في
+
+101
+00:08:45,890 --> 00:08:50,870
+الجسم وبالتالي abnormal اللي هو skin cell growth
+
+102
+00:08:50,870 --> 00:08:55,470
+بهذا في حال أنه ال antibodies اشتغلت ك antagonist
+
+103
+00:08:55,960 --> 00:08:59,320
+لكن في عندنا حالة تانية ممكن هذه الـ Antibodies of
+
+104
+00:08:59,320 --> 00:09:03,320
+the Receptors تشتغل كـ Agonists Agonists يبقى
+
+105
+00:09:03,320 --> 00:09:09,260
+هتشتغل كأنه الإنسولين هو المرتبط وبالتالي هذا
+
+106
+00:09:09,260 --> 00:09:17,660
+هيؤدي إلى حدوث Hypoiglycemia عند الشخص بما يتعلق
+
+107
+00:09:17,660 --> 00:09:22,520
+بالـ Metabolism of Insulin Action التأثيرات
+
+108
+00:09:22,520 --> 00:09:29,320
+المتعلقة بالإنسولينيعني نوعًا ما باتت معروفة
+
+109
+00:09:29,320 --> 00:09:34,260
+ومفهومة يبقى الـ metabolic effects المختلفة لكن
+
+110
+00:09:34,260 --> 00:09:39,220
+على مستوى الـ molecular mechanism وكيف الـ Insulin
+
+111
+00:09:39,220 --> 00:09:44,300
+بيعمل هذه اللي هو التأثيرات المختلفة ويؤدي إلى الـ
+
+112
+00:09:44,300 --> 00:09:48,560
+different metabolic effects يعني ما زالت تحتاج إلى
+
+113
+00:09:48,560 --> 00:09:56,660
+مزيد من الفهم أكيد الخطوة الأولىليه الـ Insulin،
+
+114
+00:09:56,660 --> 00:09:59,920
+ليه القيام بعمله؟ هو الإرتباط مع الـ receptor
+
+115
+00:09:59,920 --> 00:10:06,020
+الخاص فيه على ال cell membrane يبقى بارتباط مع
+
+116
+00:10:06,020 --> 00:10:13,230
+specific receptors على ال plasma membraneوهذا الـ
+
+117
+00:10:13,230 --> 00:10:19,850
+Insulin receptor بتكون من أربع sub units وبالتالي
+
+118
+00:10:19,850 --> 00:10:25,030
+هو عبارة عن hetero tetrameribiana four proteins،
+
+119
+00:10:25,030 --> 00:10:28,570
+four sub units وهذه ال sub units عبارة عن two
+
+120
+00:10:28,570 --> 00:10:36,500
+alpha and two beta sub unitsالـ Alpha subunit is
+
+121
+00:10:36,500 --> 00:10:39,260
+located on the outer surface of the plasma
+
+122
+00:10:39,260 --> 00:10:45,180
+membrane and contains the site where insulin binds
+
+123
+00:10:45,180 --> 00:10:50,000
+وزي ما وضعنا بيه ال figure زي ما قولنا أن الـ
+
+124
+00:10:50,000 --> 00:10:55,460
+Alpha subunits هي اللي موجودة على اللواء الخارج من
+
+125
+00:10:55,460 --> 00:11:01,000
+ال receptor و هذه ال subunits اللي بيرتبط معها ال
+
+126
+00:11:01,000 --> 00:11:07,230
+insulin و ال beta subunitsعنا هذا اللي هو الـ
+
+127
+00:11:07,230 --> 00:11:10,150
+polypeptide فى جزء منه اللي هو الـ transmembrane
+
+128
+00:11:10,150 --> 00:11:17,950
+وفى عنا جزء اللي هو الـ cytoplasmic domain وارتباط
+
+129
+00:11:17,950 --> 00:11:23,550
+الإنسولين هذا يؤدي إلى حدوث confirmation of change
+
+130
+00:11:23,550 --> 00:11:31,450
+بيه الـ beta sub unitsوالـ Insulin receptor يُعتبر
+
+131
+00:11:31,450 --> 00:11:40,430
+subfamily من الـ receptor tyrosine kinases وما زال
+
+132
+00:11:40,430 --> 00:11:46,150
+بنحكي على kinase يبقى هذا الـ البروتين هيعمل على
+
+133
+00:11:46,150 --> 00:11:52,540
+اللي هو الـ phosphorylation ل other proteinsوهذا
+
+134
+00:11:52,540 --> 00:11:56,260
+فعليًا اللي بيصير ارتباط الـ Insulin مع الـ Alpha
+
+135
+00:11:56,260 --> 00:11:59,140
+-subunit بيعمل confirmation and change في الـ Beta
+
+136
+00:11:59,140 --> 00:12:03,940
+-subunits ويؤدي إلى auto phosphorylation لـ Beta
+
+137
+00:12:03,940 --> 00:12:08,800
+-subunits وبالتالي هذا يؤدي إلى recruitment لـ
+
+138
+00:12:08,800 --> 00:12:13,960
+other cytoplasmic proteins to be phosphorylatedالـ
+
+139
+00:12:13,960 --> 00:12:17,320
+Phosphorylation بيستدعى بروتينات أخرى، وهذه
+
+140
+00:12:17,320 --> 00:12:21,220
+البروتينات الأخرى هيصلها Phosphorylation عن طريق
+
+141
+00:12:21,220 --> 00:12:26,400
+اللي هو الـ Active Tyrosine Kinase اللي هو الخاص
+
+142
+00:12:26,400 --> 00:12:31,890
+بالـ Receptorيبقى زي ما قلنا الـ Phosphorylation
+
+143
+00:12:31,890 --> 00:12:37,390
+لـ الـ الـ cytoplasmic domain لـ الـ Beta-subunit
+
+144
+00:12:37,390 --> 00:12:42,190
+بيستدعي بروتينات أخرى زي الـ SHC و بيصلها
+
+145
+00:12:42,190 --> 00:12:47,390
+Phosphorylation و عندنا أيضًا بروتين آخر اللي هو
+
+146
+00:12:47,390 --> 00:12:52,370
+الـ IRS Insulin Receptor Substrate هذه البروتينات
+
+147
+00:12:52,370 --> 00:12:57,660
+بيصلها Phosphorylationوبعد هيك هذه البروتينات
+
+148
+00:12:57,660 --> 00:13:03,780
+بترتبط مع بروتينات أخرى موجودة في الـCytoplasm
+
+149
+00:13:03,780 --> 00:13:12,640
+وبتعمللها activation مرة أخرى طبعا بالونهاية
+
+150
+00:13:12,640 --> 00:13:19,920
+الـCascade هذا عندنا العديد من الـmetabolic
+
+151
+00:13:19,920 --> 00:13:25,340
+pathways اللي طبعا مرتبطة بالأساس بوجود الانشلين
+
+152
+00:13:25,560 --> 00:13:30,340
+ومنها عنا على سبيل المثال الـ cell growth و
+
+153
+00:13:30,340 --> 00:13:34,140
+differentiation في عنا اللي هو الـ protein
+
+154
+00:13:34,140 --> 00:13:37,980
+synthesis في عنا الـ glycogen synthesis في عنا
+
+155
+00:13:37,980 --> 00:13:44,300
+المنع للـ gluconeogenesis وعنا أيضا زيادة الـ
+
+156
+00:13:44,300 --> 00:13:51,490
+lipogenesisأيضًا بالإضافة إلى الـ Translocation
+
+157
+00:13:51,490 --> 00:13:56,970
+اللي بيصير لواحدة من البروتين الـ transporters
+
+158
+00:13:56,970 --> 00:14:01,310
+الخاصة بالجلوكوز الوزيق والجلوت، يعني هذا البروتين
+
+159
+00:14:01,310 --> 00:14:07,030
+بيكون في داخل الـ cytoplasm ومع ارتباط الانسلين
+
+160
+00:14:07,030 --> 00:14:11,110
+بيصير في عندنا Translocation وبيبدأ طبعًا بفعل
+
+161
+00:14:11,110 --> 00:14:18,150
+اللي هو البروتين يسمى AKTيبقى هذا بيؤدي إلى حدوث
+
+162
+00:14:18,150 --> 00:14:22,690
+Translocation للجلوت اللي موجودة كانت في داخل الـ
+
+163
+00:14:22,690 --> 00:14:27,310
+Cytoplasm وارتباطها
+
+164
+00:14:27,310 --> 00:14:33,770
+بالـ Cell Membrane للسماح بأكتر الـ Glucose للدخول
+
+165
+00:14:33,770 --> 00:14:40,430
+إلى الخلية هذه الـ Slider اللي هو شريح للكلام اللي
+
+166
+00:14:40,430 --> 00:14:45,500
+حكيناه بالـ Slider السابقمن البروتينات اللي بيصلها
+
+167
+00:14:45,500 --> 00:14:51,040
+activation بسبب ارتباط الانسولين فيها ان الـ
+
+168
+00:14:51,040 --> 00:14:55,540
+Phosphotidylinositol-3-kinase اللي هو ده طبعا
+
+169
+00:14:55,540 --> 00:15:00,940
+البروتين بتكون وفيها growth factor receptor bound
+
+170
+00:15:00,940 --> 00:15:05,720
+البروتين اللي هو GRP2 وهدول الـ two proteins
+
+171
+00:15:05,720 --> 00:15:12,780
+بيلعبوا دور مهم في نقل الـ signal إلى يعني داخل
+
+172
+00:15:13,090 --> 00:15:18,550
+الخلية أيضًا برضه أنه الـ Signaling Pathway آخر
+
+173
+00:15:18,550 --> 00:15:22,370
+اللي برضه مرتبط بارتباط الـ Insulin على الـ
+
+174
+00:15:22,370 --> 00:15:26,530
+Receptors الـ Mitogen Activated Protein كينازي
+
+175
+00:15:26,530 --> 00:15:31,370
+اللي هو الـ MAP كينازي و اللي بيشتغل من خلال ال
+
+176
+00:15:31,370 --> 00:15:39,620
+activation للرأس أيضًا أن الـ PI3 زي ما قلنابسله
+
+177
+00:15:39,620 --> 00:15:45,200
+activation و هو بدوره بيعمل activation لـ AKT و
+
+178
+00:15:45,200 --> 00:15:51,820
+الـ AKT اللي هي بتلعب دور مهم زي ما حكينا في الـ
+
+179
+00:15:51,820 --> 00:15:57,160
+Translocation اللي بده يصير لجلوت Transporter
+
+180
+00:15:57,160 --> 00:16:04,420
+بروتين وهذا الـ AKT بيشتغل من خلال الـ PDK1
+
+181
+00:16:06,190 --> 00:16:12,070
+ال effect اللي هتنتج بالخلايا أو بال tissue اللي
+
+182
+00:16:12,070 --> 00:16:17,390
+هيرتبط فيه ال insulin ممكن يكون فيها بعض الاختلاف
+
+183
+00:16:17,390 --> 00:16:22,090
+يبقى من tissue لآخر ممكن يكون فينا بعض الاختلاف
+
+184
+00:16:22,090 --> 00:16:28,910
+اللي هو ناتج عن ارتباط ال insulin بهذه ال cells
+
+185
+00:16:28,910 --> 00:16:33,790
+على سبيل المثال عندنا enescalatal muscle and
+
+186
+00:16:33,790 --> 00:16:37,680
+adipose tissueالـ AKT تقوم بتحريك التحريك
+
+187
+00:16:37,680 --> 00:16:43,180
+الجلوكوزي بمشاركة التحريك الجلوكوزي لـ GLUT4 كما
+
+188
+00:16:43,180 --> 00:16:48,160
+قلت، تحريك الجلوكوزي لـ GLUT4 يكون موجود في داخل
+
+189
+00:16:48,160 --> 00:16:52,600
+الـ cytoplasm و بسله التحريك الجلوكوزي و بيرطبط مع
+
+190
+00:16:52,600 --> 00:17:00,080
+الـ cell membrane عشان يسمح بدخول الجلوكوزي في الـ
+
+191
+00:17:00,080 --> 00:17:08,140
+liver الـ AKT تفسفوريلاتand inactivates GSK3β الـ
+
+192
+00:17:08,140 --> 00:17:14,920
+glycogen synthase kinase 3β وبالتالي هذا بيؤدي إلى
+
+193
+00:17:14,920 --> 00:17:22,400
+enhancing the glycogen synthesis طبعا
+
+194
+00:17:22,400 --> 00:17:30,380
+ال GSK3β هو عبارة عن inhibitor لل glycogen
+
+195
+00:17:30,380 --> 00:17:34,780
+synthaseأو inactivating agent للـ glycogen
+
+196
+00:17:34,780 --> 00:17:39,680
+synthase اللي هو ال .. ال .. ال enzyme اللي بيلعب
+
+197
+00:17:39,680 --> 00:17:43,600
+دور في عملية ال synthesis لل glycogen لما احنا
+
+198
+00:17:43,600 --> 00:17:48,940
+بنعمل inactivation لل GSK3β تماما بيجيب نعمل
+
+199
+00:17:48,940 --> 00:17:53,000
+inhibition لل inhibitor وبالتالي هيصير في عنا
+
+200
+00:17:53,000 --> 00:17:58,620
+active glycogen synthase وبالتالي glycogen
+
+201
+00:17:58,620 --> 00:18:05,240
+synthesisالـ AKT أيضًا تخلص الـ gluconeogenesis
+
+202
+00:18:05,240 --> 00:18:09,340
+لأنه احنا عندنا موجود كميات كبيرة من الجلوكوز
+
+203
+00:18:09,340 --> 00:18:14,560
+وبالتالي احنا مش في حاجة انه نصنع الجلوكوز من
+
+204
+00:18:14,560 --> 00:18:19,020
+مصادر اللي و غير كربوهيدراتية تمام؟ يبقى بيصير في
+
+205
+00:18:19,020 --> 00:18:23,820
+عندنا suppression لل gluconeogenesis و بالمقابل
+
+206
+00:18:23,820 --> 00:18:28,040
+بيصير في عندنا activation لل lipogenesis in the
+
+207
+00:18:28,040 --> 00:18:28,440
+liver
+
+208
+00:18:31,180 --> 00:18:36,040
+بما يتعلق بيه لـ Glucose Transport نقل الجلوكوز
+
+209
+00:18:36,040 --> 00:18:41,080
+ودخوله إلى داخل الخلايا في عنا two families of
+
+210
+00:18:41,080 --> 00:18:46,060
+proteins مسئولة عن هذا الأمر في عنا الـ Sodium
+
+211
+00:18:46,060 --> 00:18:51,680
+Dependent Glucose Transporters الـ SGLT وفي عنا
+
+212
+00:18:51,680 --> 00:18:58,410
+العائلة التانيةاللي هو الـ Glucose Transporters أو
+
+213
+00:18:58,410 --> 00:19:01,430
+Facilitative Glucose Transporters اللي هو الـ GLUT
+
+214
+00:19:01,430 --> 00:19:07,090
+بيها دول العائلتين من البروتين أو من الـ Glucose
+
+215
+00:19:07,090 --> 00:19:12,070
+Transporters مسئولين عن دخول الـ Glucose إلى داخل
+
+216
+00:19:12,070 --> 00:19:16,750
+الخلايا النوع الأول Sodium Dependent Glucose
+
+217
+00:19:16,750 --> 00:19:21,080
+Transportersهذه بتستخدم اللي هو الـ
+
+218
+00:19:21,080 --> 00:19:25,360
+Electrochemical Sodium Gradient To Transport
+
+219
+00:19:25,360 --> 00:19:30,860
+Glucose Against Its Concentration Gradient وهذا
+
+220
+00:19:30,860 --> 00:19:39,000
+البروتين فعلياً بيعمل على نقل ال Sodium ومع ال
+
+221
+00:19:39,000 --> 00:19:45,020
+Sodium أيضاً بيدخل عندنا لجلوكوز إلى داخل الخلية
+
+222
+00:19:45,020 --> 00:19:52,100
+زي ما واضح به ال figure هذا الـ SGL2بيعمل على دخول
+
+223
+00:19:52,100 --> 00:19:57,120
+الـ Sodium تمامًا و أيضًا بيعمل على دخول الـ
+
+224
+00:19:57,120 --> 00:20:02,420
+Glucose في نفس الوقت إلى داخل الخلايا زي الخلايا
+
+225
+00:20:02,420 --> 00:20:04,860
+الموجودة بالأمعاء على سبيل المثال هو الـ
+
+226
+00:20:04,860 --> 00:20:08,940
+Enterocytes و اللي يبجي عن طريق اللي اللي قلته
+
+227
+00:20:08,940 --> 00:20:13,720
+بيصير فيه أنه absorption للـ Glucose و دخوله إلى
+
+228
+00:20:13,720 --> 00:20:17,740
+داخل خلايا الأمعاء اللي هو الـ Enterocytes
+
+229
+00:20:23,600 --> 00:20:28,700
+الـ SGLT تدفع تحرير الجلوكوز وجالكتوز من لوم الصدر
+
+230
+00:20:28,700 --> 00:20:36,440
+الصغير والتعادل من الدم في الجلديبقى كمان الـ SGLT
+
+231
+00:20:36,440 --> 00:20:41,420
+برضه بتلعب دور في عملية الـ Reabsorption مرة أخرى
+
+232
+00:20:41,420 --> 00:20:44,900
+لجلوكوز بعد ما تصير عندنا اللي هو عملية ال
+
+233
+00:20:44,900 --> 00:20:50,840
+filtration وبيدخل لجلوكوز ضمن الفلترات كما احنا
+
+234
+00:20:50,840 --> 00:20:54,240
+عارفين في أول جزء من ال tubules اللي هو عندنا ال
+
+235
+00:20:54,240 --> 00:20:57,140
+proximal convoluted tubules بيصير في عندنا
+
+236
+00:20:57,140 --> 00:21:03,620
+Reabsorption لالكمية الأكبر أو لأغلب الـ Glucose
+
+237
+00:21:03,620 --> 00:21:08,340
+الموجود في الفلترات و اللي بيلعب دور في هذه اللي
+
+238
+00:21:08,340 --> 00:21:12,540
+هو العملية الـ Reabsorption هو برضه الـ SGL2
+
+239
+00:21:12,540 --> 00:21:17,900
+بروتينز النوع
+
+240
+00:21:17,900 --> 00:21:22,220
+التاني من ال Transporters هو اللي هو ال Glut
+
+241
+00:21:22,220 --> 00:21:26,460
+family of membrane proteins that are encoded by
+
+242
+00:21:26,460 --> 00:21:38,660
+the SLC2 genesوعنا عدد يعني من هذا ال proteins من
+
+243
+00:21:38,660 --> 00:21:44,940
+اللي هو glute 1 لغاية glute 14 وتم تسميتهم يعني
+
+244
+00:21:44,940 --> 00:21:49,920
+بناء على الوقت اكتشافهم، تمام؟ وglute 1 يعني هو
+
+245
+00:21:49,920 --> 00:21:56,900
+هذا أول protein تم اكتشافه في هذهالعائلة، وتم
+
+246
+00:21:56,900 --> 00:22:01,760
+تقسيم هذه البروتينات إلى تلت أقسام بعد هيك، زي ما
+
+247
+00:22:01,760 --> 00:22:04,000
+احنا شايفين في عندنا class one، في عندنا class
+
+248
+00:22:04,000 --> 00:22:08,400
+two، وفي عندنا اللي هو class three، هذه التقسيمة
+
+249
+00:22:08,400 --> 00:22:13,400
+تمت بناءً على الـ sequence similarities، وبناءً
+
+250
+00:22:13,400 --> 00:22:19,380
+على اللي هو التشابه بالخصائص للبروتينات المختلفة
+
+251
+00:22:22,100 --> 00:22:26,260
+البروتينات المختلفة يعني موجودة زي ما هو واضح حال
+
+252
+00:22:26,260 --> 00:22:30,680
+من خلال الـ Table فيه tissues مختلفة، يعني إن الـ
+
+253
+00:22:30,680 --> 00:22:33,660
+Glut1 على سبيل المثالاللي هو موجود بالـ
+
+254
+00:22:33,660 --> 00:22:37,800
+Erythrocyte، الـ Brain، Blood-Brain Barrier، Fetal
+
+255
+00:22:37,800 --> 00:22:41,300
+Tissues، Glut2 موجود في الـ Liver و Beta Cells of
+
+256
+00:22:41,300 --> 00:22:45,200
+the Pancreas، Glut4، Skeletal Muscle و Cardiac
+
+257
+00:22:45,200 --> 00:22:48,480
+Muscle تمام، يبقى عندنا الأنواع المختلفة من هذه
+
+258
+00:22:48,480 --> 00:22:52,860
+البروتينات موجودة في tissues مختلفة وممكن نجي أكتر
+
+259
+00:22:52,860 --> 00:23:01,270
+من نوع موجود في نفس الـ tissueوبعض هذه الأنواع من
+
+260
+00:23:01,270 --> 00:23:07,550
+الـ protein اللي هو الـ Glute بيلعب دور غير اللي
+
+261
+00:23:07,550 --> 00:23:13,530
+هو موضوع نقل لـ Glucose زي أن الـ Glute 9 اللي هو
+
+262
+00:23:13,530 --> 00:23:18,300
+Transports Ureaعنا على سبيل المثال اللي هو «Glut
+
+263
+00:23:18,300 --> 00:23:24,260
+-13» «هيدا» «ترانسبورز» «مايو» «انوسيتول» اللي هو
+
+264
+00:23:24,260 --> 00:23:29,000
+فيه يعني tissues زي الـ «براين» والـ «أليبوز»
+
+265
+00:23:29,000 --> 00:23:35,200
+tissue يبقى أغلب هذه البروتينات مسئولة عن نقل لـ
+
+266
+00:23:35,200 --> 00:23:41,000
+«جلوكوز» لكن عنا فيه زي ما شوفنا البعض منها بينقل
+
+267
+00:23:41,000 --> 00:23:42,360
+بواد أخرى
+
+268
+00:23:46,070 --> 00:23:49,510
+هؤلاء الانتجارات تم تسمح بـ Glut-1 لـ Glut-14
+
+269
+00:23:49,510 --> 00:23:55,390
+بناءً على حركة الانتجارات التي تم اكتشافها، 11 تم
+
+270
+00:23:55,390 --> 00:24:02,410
+إظهارها لإنتجار الكلوكوز، وكذلك الكثير
+
+271
+00:24:02,410 --> 00:24:07,470
+منهم ينتجون أيضًا ريكزوز مثل Galactose, Fractose,
+
+272
+00:24:07,930 --> 00:24:14,310
+Manose و Exyloseكمثال على هذه البروتينات اللي
+
+273
+00:24:14,310 --> 00:24:19,310
+بتعمل على نقل الجلوكوز لو حكينا على glut4 when
+
+274
+00:24:19,310 --> 00:24:23,150
+circulating insulin concentrations are low most of
+
+275
+00:24:23,150 --> 00:24:26,630
+the glut4 is localized in intracellular
+
+276
+00:24:26,630 --> 00:24:30,810
+compartments يبقى لما نكون عندنا مستويات الانسولين
+
+277
+00:24:30,810 --> 00:24:35,830
+قليلة منخفضة يعني بمعناه أنه عندنا ال glucose
+
+278
+00:24:35,830 --> 00:24:40,020
+concentration في الدم يعني ضمنالـ Reference
+
+279
+00:24:40,020 --> 00:24:43,860
+Interval أو ضمن يعني الـ Reference Range يبقى
+
+280
+00:24:43,860 --> 00:24:47,400
+بيكون أن الـ Glucose Transporter اللي هو مثلًا
+
+281
+00:24:47,400 --> 00:24:53,240
+مثلًا Glut4 بيكون موجود في داخل الـ Cytoplasm في
+
+282
+00:24:53,240 --> 00:24:57,420
+داخل الخلية، بيكون مش موجود على ال cell membrane
+
+283
+00:24:57,420 --> 00:25:00,960
+يبقى Localized in Intracellular compartments and
+
+284
+00:25:00,960 --> 00:25:08,310
+is inactive لكن بعد ما الإنسان بيتناول الطعامو
+
+285
+00:25:08,310 --> 00:25:12,330
+اللي هو الموجود فيه carbohydrates يبقى بيبدأ يصير
+
+286
+00:25:12,330 --> 00:25:19,410
+فينا ارتفاع في مستوى ال insulin و زي ما شفنا بال
+
+287
+00:25:19,410 --> 00:25:24,570
+figure الخاص بالميكانزم من ضمن ال mechanisms اللي
+
+288
+00:25:24,570 --> 00:25:30,910
+بيقوم فيها ال insulin هوالـ Activation لـ AKT، وهو
+
+289
+00:25:30,910 --> 00:25:37,410
+مسئول عن حدوث Translocation لجلوتفور لبلازماممبرين
+
+290
+00:25:37,410 --> 00:25:42,630
+وبالتالي دخول كميات أكبر من الجلوكوز into skeletal
+
+291
+00:25:42,630 --> 00:25:50,510
+muscle and fatالإنسيولين يدفع الجلوكوز للتواصل إلى
+
+292
+00:25:50,510 --> 00:25:54,250
+الجلد الاسكليتالي يكون مفارقًا في الـ Type 2
+
+293
+00:25:54,250 --> 00:25:58,450
+Diabetes Mellitus ولكن الميكانيزم لم يتم إصلاحه،
+
+294
+00:25:58,450 --> 00:26:02,430
+بهذا من المشكلات الموجودة في الناس اللي عندهم Type
+
+295
+00:26:02,430 --> 00:26:05,860
+2 Diabetes Mellitusإنه عندنا الـ Insulin
+
+296
+00:26:05,860 --> 00:26:09,780
+Stimulated Glucose Transport اللي هو زي ما حكينا
+
+297
+00:26:09,780 --> 00:26:12,360
+إنه الـ Translocation اللي بتسيلها للـ
+
+298
+00:26:12,360 --> 00:26:15,900
+Transporters و اللي بتسمح بدخول كميات كبيرة من الـ
+
+299
+00:26:15,900 --> 00:26:20,880
+Glucose هذه بيصير فيها مشكلة عند الناس اللي عندهم
+
+300
+00:26:20,880 --> 00:26:24,520
+type 2 diabetes mellitus وهذا اللي بيؤدي إلى طبعا
+
+301
+00:26:24,520 --> 00:26:28,880
+الـ Hyperglycemia و الارتفاع اللي هو الـ Glucose
+
+302
+00:26:28,880 --> 00:26:33,180
+الكبير اللي بيصير بعد تناول الواجبات
+
+303
+00:26:36,140 --> 00:26:40,380
+الهرمون الآخر الأساسي اللي بيلعب دور في عملية الـ
+
+304
+00:26:40,380 --> 00:26:46,460
+Regulation للجلوكوز أنه الـ Glucagon هو عبارة عن
+
+305
+00:26:46,460 --> 00:26:52,320
+29-Amino Acid Polypeptide وبيتم إفرازه من خلايا
+
+306
+00:26:52,320 --> 00:26:56,820
+تسمى الـ Fossils وهذه موجودة في الـ Islets of
+
+307
+00:26:56,820 --> 00:27:04,370
+Langerhans في البنكرياسالـ Glucagon أيضًا بيُفرز
+
+308
+00:27:04,370 --> 00:27:10,530
+أو بيتم بـ cellosynthesis in an inactive form Pro
+
+309
+00:27:10,530 --> 00:27:18,140
+-Glucagon وبعد هيك بيصير فيها أناكتفيشن لهذا
+
+310
+00:27:18,140 --> 00:27:22,640
+البروتين عن طريق الـ Pro-Hormone Convertease-II
+
+311
+00:27:22,640 --> 00:27:27,860
+اللي بيصير كليفش لجزء من الـ Pro-Glucagon وبيتحول
+
+312
+00:27:27,860 --> 00:27:33,100
+إلى Active-Glucagon Major target organ for
+
+313
+00:27:33,100 --> 00:27:37,960
+glucagon is the liverواحنا عارفين إنه الـ Glucagon
+
+314
+00:27:37,960 --> 00:27:43,600
+عبارة عن hyperglycemic agent يبقى هو بيعمل على رفع
+
+315
+00:27:43,600 --> 00:27:53,280
+مستوى لجلوجوز في الدم في حال اللي هو الصيام يبقى
+
+316
+00:27:53,280 --> 00:27:57,660
+فيه ال liver، ال glucagon بيرتبط لنوع من ال
+
+317
+00:27:57,660 --> 00:28:01,660
+receptors اللي يسمى G-protein coupled receptor
+
+318
+00:28:03,400 --> 00:28:08,720
+الذي يتم إظهاره عاليًا في الجلد والقلق وعلى أقل
+
+319
+00:28:08,720 --> 00:28:14,400
+مدى في أشياء أخرى مثل قلق أدبوه، بانكرياه وعقل
+
+320
+00:28:14,400 --> 00:28:20,420
+عقلي.الجلوكاجون تشجع نشطة الوصول للجلوكوز في الجلد
+
+321
+00:28:20,880 --> 00:28:24,840
+بـ Predominantly by Glucogenolysis بهادي العمليات
+
+322
+00:28:24,840 --> 00:28:28,820
+اللي بيشتغل من خلالها الجلوكاجون واللي بيعمل على
+
+323
+00:28:28,820 --> 00:28:32,500
+رفع مستوى الجلوكوز في الدم أن العملية الأولى
+
+324
+00:28:32,500 --> 00:28:35,660
+Glucogenolysis اللي هو عملية التكسير اللي بتصير
+
+325
+00:28:35,660 --> 00:28:42,400
+للـGlycogen اللي تم تخزينه وأيضا يبقى الانتاج هان
+
+326
+00:28:42,400 --> 00:28:48,180
+لجلوكوز من اللي هو الـGlycogen stores وأيضا برضه
+
+327
+00:28:48,180 --> 00:28:52,090
+فيه أنه Gluconeogenesisاللي هو production of
+
+328
+00:28:52,090 --> 00:28:56,470
+glucose from non-carbohydrate sources بجهة دي برضه
+
+329
+00:28:56,470 --> 00:29:03,670
+العملية بسلها activation وبرضه بنفس الوقت هان
+
+330
+00:29:03,670 --> 00:29:07,890
+عملية اللي هو التخزين للجلوكوز بسلها inhibition
+
+331
+00:29:07,890 --> 00:29:11,690
+بجهة glucogenesis بسلها inhibition لإن احنا هنا
+
+332
+00:29:11,690 --> 00:29:17,130
+بحاجة إلى رفع مستوى الجلوكوز في الدم
+
+333
+00:29:19,720 --> 00:29:23,220
+الـ Glucagon secretion is regulated primarily by
+
+334
+00:29:23,220 --> 00:29:27,420
+plasma glucose concentrations، بيحسب مستوى
+
+335
+00:29:27,420 --> 00:29:31,700
+الجلوكوز في الدم، إذا انخفض مستوى الجلوكوز في الدم
+
+336
+00:29:31,700 --> 00:29:37,460
+عن 70، يبجيها أن بيصير في عندنا stimulation للـ
+
+337
+00:29:37,460 --> 00:29:41,160
+alpha cells في البنكرياز عشان تعمل release
+
+338
+00:29:41,160 --> 00:29:42,580
+للجلوكاجون
+
+339
+00:29:44,380 --> 00:29:47,700
+with low and high plasma glucose being stimulatory
+
+340
+00:29:47,700 --> 00:29:52,220
+and inhibitory respectively ولمّا يكون عندنا ال
+
+341
+00:29:52,220 --> 00:29:56,360
+plasma glucose منخفضة يبقى ده بيعمل stimulation ل
+
+342
+00:29:56,360 --> 00:30:01,480
+ال release of glucagon لكن لو كان عندنا ال plasma
+
+343
+00:30:01,480 --> 00:30:06,190
+glucose مرتفعةيبقى معناته حيصير فيه إنه في هذه
+
+344
+00:30:06,190 --> 00:30:10,250
+الحالة Release لـ Insulin و اللي هيعمل Inhibition
+
+345
+00:30:10,250 --> 00:30:15,030
+على الـ Alpha Cells وبالتالي هيقلل من إفراز
+
+346
+00:30:15,030 --> 00:30:19,590
+لـGlucagon Long-standing diabetes mellitus impairs
+
+347
+00:30:19,590 --> 00:30:24,110
+the glucagon response to hypoglycemia وهذه مشكلة
+
+348
+00:30:24,110 --> 00:30:30,790
+من المشكلات اللي ممكن تكون موجودة عند الناس اللي
+
+349
+00:30:30,790 --> 00:30:37,630
+عندهم diabetesواللي بتؤدي إلى حدوث Hypoiglycemia
+
+350
+00:30:37,630 --> 00:30:42,810
+يبقى الـ Longstanding Diabetes Mellitus بيأثر على
+
+351
+00:30:42,810 --> 00:30:49,010
+الـ Glucagon response to Hypoiglycemiaيبقى المفروض
+
+352
+00:30:49,010 --> 00:30:52,310
+إحنا زي ما قلنا إنه لو صار فينا انخفاض لجلوكوز عن
+
+353
+00:30:52,310 --> 00:30:56,210
+70 ميلي جرام per ديسليتر يبقى مباشرة المفروض يصير
+
+354
+00:30:56,210 --> 00:31:01,150
+في release للـGlucagon لكن المشكلة إنه الإصابة
+
+355
+00:31:01,150 --> 00:31:05,430
+بفترة طويلة بالـDiabetes Mellitus هذا هيأثر على
+
+356
+00:31:05,430 --> 00:31:10,910
+هذه العملية وبالتالي هذا هيزيد من الـHypoglycemic
+
+357
+00:31:10,910 --> 00:31:12,050
+episodes
+
+358
+00:31:15,550 --> 00:31:19,530
+بما يتعلق بالناس اللي عندهم type 1 diabetes
+
+359
+00:31:19,530 --> 00:31:27,410
+mellitus ومن خلال الأبحاث المختلفة لجوا إنه اللي
+
+360
+00:31:27,410 --> 00:31:29,770
+هو الـ response أو الـ glucagonal response
+
+361
+00:31:29,770 --> 00:31:37,130
+لهيبوإجليسيميا ممكن تحدث في فترة قصيرة لو الناس
+
+362
+00:31:37,130 --> 00:31:40,880
+اللي عندهم type 1 diabetes mellitusطبعا يبقى ممكن
+
+363
+00:31:40,880 --> 00:31:46,300
+هذه تحدث في فترة قصيرة يعني ممكن تحدث في فترة اللي
+
+364
+00:31:46,300 --> 00:31:52,380
+هي لا تتجاوز ممكن الشهر أو الشهرينممكن يصير في عنا
+
+365
+00:31:52,380 --> 00:31:58,340
+ليه مشكلة الـGlucagon أو اللي هو انخفاض في
+
+366
+00:31:58,340 --> 00:32:02,520
+الـGlucagon response to hypoglycemia بالتالي هذا
+
+367
+00:32:02,520 --> 00:32:09,680
+قلنا إنه بيعمل ممكن مشكلة وممكن يزيد من اللي هو
+
+368
+00:32:09,680 --> 00:32:14,360
+حدوث الـhypoglycemia episodes and هدول المرضى
+
+369
+00:32:14,360 --> 00:32:19,340
+Stress exercise and amino acids induce glucagon
+
+370
+00:32:19,340 --> 00:32:24,040
+releaseالـ IB هذه كلها أكيد بتحتاج إلى ارتفاع في
+
+371
+00:32:24,040 --> 00:32:29,840
+مستوى الجلوكوزة وبالتالي كلها بتعمل على زيادة الـ
+
+372
+00:32:29,840 --> 00:32:33,940
+release of glucagon طيب ال stress ال exercise دم
+
+373
+00:32:33,940 --> 00:32:37,300
+متفقين أن هذه بتحتاج إلى اللي هو الجلوكوزة
+
+374
+00:32:37,300 --> 00:32:40,140
+وبالتالي بدنا glucagon release طب ال amino acids
+
+375
+00:32:40,140 --> 00:32:45,900
+يعني المفروض ال amino acids أمتى بتصير موجودة في
+
+376
+00:32:45,900 --> 00:32:48,240
+الدم أو تزيد ال concentration في الدم بعد تناول
+
+377
+00:32:48,240 --> 00:32:52,980
+وجبةطب ليش بقى أنتنا هو الوشبة بده يرتفع عندنا
+
+378
+00:32:52,980 --> 00:32:56,120
+الـGlucagon؟ مع أنه المفروض أنه يصير في عندنا
+
+379
+00:32:56,120 --> 00:33:01,400
+انخفاض، واللي يرتفع هو الـInsulin، وفعليًا
+
+380
+00:33:01,400 --> 00:33:07,740
+الـInsulin بيرتفع، تمام؟ لكن برضه الـAmino Acids
+
+381
+00:33:07,740 --> 00:33:15,570
+بتعمل على رفع الـGlucagonوهذه العملية يعني فيها
+
+382
+00:33:15,570 --> 00:33:21,290
+توازن ومرتبطة بالـ glucose concentration ومرتبطة
+
+383
+00:33:21,290 --> 00:33:27,570
+بالـ insulin أيضًا لأنه احنا عندنا الجسم الآن بعد
+
+384
+00:33:27,570 --> 00:33:31,870
+تناول وجبةصار فينا ارتفاع في الـ Amino Acids صار
+
+385
+00:33:31,870 --> 00:33:36,350
+فينا ارتفاع في الجلوكوز صار فينا إفراز للإنسلين
+
+386
+00:33:36,350 --> 00:33:40,210
+والإنسلين بدأ يخفض من مستويات الجلوكوز بالدم يبقى
+
+387
+00:33:40,210 --> 00:33:44,550
+أحنا ما نقدرش أنه نوقف عمل الـ Alpha cells
+
+388
+00:33:44,550 --> 00:33:48,630
+ومايكونش فينا Glucagon موجود في الدم لأن هذا ممكن
+
+389
+00:33:48,630 --> 00:33:52,750
+يؤدي إلى حدوث Hypo-Glycemia يعني هذه العملية بيصير
+
+390
+00:33:52,750 --> 00:33:57,110
+فيها توازن وبيبدأ يصير فينا يعني Release لكميات
+
+391
+00:33:57,520 --> 00:34:02,580
+بسيطة من الـGlucagon عشان يمنع من حدوث
+
+392
+00:34:02,580 --> 00:34:09,040
+الـHypoglycemia.إنسولين يهيبط إطلاق الـGlucagon من
+
+393
+00:34:09,040 --> 00:34:13,360
+البنكريات ويقلل إطلاق الـGlucagon في إظهار الجنة
+
+394
+00:34:13,360 --> 00:34:17,920
+بمجرد إضافة بيو-سينتيزاتها زي ما حكينا قبل شوية
+
+395
+00:34:17,920 --> 00:34:22,000
+قولنا إن الإنسولين بيعمل Inhibition على الـAlpha
+
+396
+00:34:22,000 --> 00:34:29,090
+cellsوهي بالتالي بيمنع الـ glucagon release وهذا
+
+397
+00:34:29,090 --> 00:34:33,490
+بيكون عن طريق اللي هو خفض الـ glucagon gene
+
+398
+00:34:33,490 --> 00:34:41,110
+expression في أخلق الـ alpha cells increase
+
+399
+00:34:41,110 --> 00:34:44,350
+in glucagon concentrations secondary to insulin
+
+400
+00:34:44,350 --> 00:34:47,870
+deficiency are believed to contribute to the
+
+401
+00:34:47,870 --> 00:34:53,090
+hyperglycemia and ketosis of diabetesأحنا قلنا إنه
+
+402
+00:34:53,090 --> 00:34:57,490
+الـ Insulin بيعمل Inhibition على الـ Alpha Cells
+
+403
+00:34:57,490 --> 00:35:03,390
+وبيمنع من إفراز الجلوكاجون الآن في حالات اللي هو
+
+404
+00:35:03,390 --> 00:35:06,890
+الـ Type I Diabetes Mellitus زي ما قلنا إنه في الـ
+
+405
+00:35:06,890 --> 00:35:11,310
+Type I فينا Absolute Deficiency of Insulin يبقى
+
+406
+00:35:11,310 --> 00:35:14,390
+مازال الـ Insulin مش موجود يبقى الـ Inhibitor
+
+407
+00:35:14,390 --> 00:35:18,490
+Effect اللي بيقوم فيها الـ Insulin على الـ Alpha
+
+408
+00:35:18,490 --> 00:35:23,650
+Cells مش هتكون موجودةبيادة هيؤدي إلى زيادة في
+
+409
+00:35:23,650 --> 00:35:28,530
+الـglucagon concentration وما زال صار في عنا زيادة
+
+410
+00:35:28,530 --> 00:35:31,170
+في الـglucagon concentration هصير في عنا
+
+411
+00:35:31,170 --> 00:35:35,410
+stimulation للـgluconeogenesis وهصير في عنا الو
+
+412
+00:35:35,410 --> 00:35:39,450
+اكسيداشن لـالـ Fatty Acids وبالتالي حيصير فيها إنه
+
+413
+00:35:39,450 --> 00:35:45,770
+إنتاج لكميات كبيرة من الـ Ketone Bodies وهذا اللي
+
+414
+00:35:45,770 --> 00:35:50,930
+ممكن يؤدي إلى الـ Ketosis أو Ketoacidosis عند
+
+415
+00:35:50,930 --> 00:35:55,330
+الناس اللي عندهم type 1 diabetes malatus بعدم وجود
+
+416
+00:35:55,330 --> 00:36:00,790
+الإنسولين مع ارتفاع الجلوكاجون هذا اللي ممكن يكون
+
+417
+00:36:00,790 --> 00:36:03,570
+سبب حدوث الـ Ketosis
+
+418
+00:36:06,070 --> 00:36:11,360
+غير الـ Alpha Cells، فينا أيضًا خلايا أخرىبتفرز
+
+419
+00:36:11,360 --> 00:36:16,680
+الـ Pro-Glucagon ومن هذه الخلايا عندنا الـ
+
+420
+00:36:16,680 --> 00:36:20,000
+Enteroendocrine الـ cells الموجودة في الأمعاء
+
+421
+00:36:20,000 --> 00:36:27,120
+وعندنا أيضًا الـ neurons اللي هي هذه الـ neurons
+
+422
+00:36:27,120 --> 00:36:30,360
+هي اللي بتعمل على نقل يعني نوع من الـ neurons اللي
+
+423
+00:36:30,360 --> 00:36:35,580
+بيعمل على نقل الـ signals من الـ digestive tract
+
+424
+00:36:35,580 --> 00:36:40,560
+لبراين أو من براين لـالـ Digestive Attract بيهدى
+
+425
+00:36:40,560 --> 00:36:45,000
+الخلايا بتعمل أيضًا على إفراز أو إنتاج لـ Pro
+
+426
+00:36:45,000 --> 00:36:51,280
+-Glucagon في الـ Intestinal L-cells Pro-Glucagon
+
+427
+00:36:51,280 --> 00:36:55,940
+بيصلوا برضه إكليفج عن طريق Enzymes لأن Pro-Hormone
+
+428
+00:36:55,940 --> 00:37:01,870
+Converters 1A3وبيحول هذا الانزيم بيحول الـ Pro
+
+429
+00:37:01,870 --> 00:37:06,990
+-Glucagon إلى Glucagon-like peptide اللي يعني GLP
+
+430
+00:37:06,990 --> 00:37:15,430
+-1 و GLP-2 و أيضًا hormones أخرى هذا النوع من ال
+
+431
+00:37:15,430 --> 00:37:21,830
+hormones و اللي بيتم إنتاجه بسبب التناول الطعام
+
+432
+00:37:22,770 --> 00:37:26,070
+بيعمل stimulation للـ beta cells الموجودة
+
+433
+00:37:26,070 --> 00:37:32,350
+بالبنكرياس لإفراز الإنسولين يبقى potentiate
+
+434
+00:37:32,350 --> 00:37:36,750
+glucose-induced insulin secretion أيضًا وبيعمل
+
+435
+00:37:36,750 --> 00:37:42,130
+inhibition لـglucagon secretionبالـ GLB1 وعنا
+
+436
+00:37:42,130 --> 00:37:47,070
+أيضًا هرمون آخر Gestric Inhibitory Polypeptide أو
+
+437
+00:37:47,070 --> 00:37:49,510
+بروتين آخر اللي هو الـ Gestric Inhibitory
+
+438
+00:37:49,510 --> 00:37:55,710
+Polypeptide برضه هدول اللي هو الـ two hormones
+
+439
+00:37:55,710 --> 00:38:00,830
+مسئولين for up to 70% of postprandial insulin
+
+440
+00:38:00,830 --> 00:38:01,810
+secretion
+
+441
+00:38:04,000 --> 00:38:08,740
+يبقى مع تناول الطعام، في عندنا هرمونات اللي بتتم
+
+442
+00:38:08,740 --> 00:38:13,460
+إنتاجها، وهذه الهرمونات بتعمل اللي هو stimulation
+
+443
+00:38:13,460 --> 00:38:20,160
+لزيادة الـ Insulin وبالتالي عدم ارتفاع الـ glucose
+
+444
+00:38:20,160 --> 00:38:23,660
+في الدم إلى مستويات مرتفعة
+
+445
+00:38:26,930 --> 00:38:34,350
+الـ GLP-1 موجودة في تشيز مختلفة ومش فقط في الـ
+
+446
+00:38:34,350 --> 00:38:40,550
+Pancreas يبقى widely expressed وبتلعب دور مهم في
+
+447
+00:38:40,550 --> 00:38:45,210
+عملية الـ regulation للجلوكوز concentration من
+
+448
+00:38:45,210 --> 00:38:51,670
+خلال ميكانيزمز مختلفة ومن ضمن هذه الميكانيزمز إن
+
+449
+00:38:51,670 --> 00:38:55,930
+الـ inhibition of glucose production and food
+
+450
+00:38:55,930 --> 00:39:02,500
+intakeتمام، يبقى من ضمن اللي هو الـ .. الـ
+
+451
+00:39:02,500 --> 00:39:04,560
+mechanisms طبعا زي ما حكيها أنا السابق لإنه بزيد
+
+452
+00:39:04,560 --> 00:39:10,780
+الـ insulin secretion لكن برضه بيمنع من ال glucose
+
+453
+00:39:10,780 --> 00:39:15,580
+production وبيمنع برضه أو بيقلل ممكن من ال uptake
+
+454
+00:39:15,580 --> 00:39:22,080
+وبالتالي ال food intake عشان هيك ال GLP-1
+
+455
+00:39:22,080 --> 00:39:26,020
+analoguesare generating interest in the treatment
+
+456
+00:39:26,020 --> 00:39:31,800
+of type 2 diabetes في عندنا أدوية وهذه عبارة عن
+
+457
+00:39:31,800 --> 00:39:37,800
+GLB1 Analog تمام بيغير أنه ممكن تعمل release
+
+458
+00:39:37,800 --> 00:39:41,920
+للإنسلين لكن برضه بتقلل من إنتاج الوالي glucose
+
+459
+00:39:41,920 --> 00:39:50,240
+وأيضا بتقلل من ال uptakeوفي أربع أدوية يعني تم
+
+460
+00:39:50,240 --> 00:39:55,240
+إنتاجها وحصلت على الـ Approval من الـ Food and
+
+461
+00:39:55,240 --> 00:40:00,580
+Drug Administration لإستعمالها مع مرضى Type 2
+
+462
+00:40:00,580 --> 00:40:02,440
+Diabetes Mellitus
+
diff --git a/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/wNcigeivKdA_raw.json b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/wNcigeivKdA_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..9d6643a63111cd30023d642461882acb422c3f2b
--- /dev/null
+++ b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/wNcigeivKdA_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 1426, "start": 1.84, "end": 14.26, "text": "بسم الله الرحمن الرحيم نستكمل مع محاضرة diabetes mellitus ووصلنا لغاية ال insulin و ال antibodies to insulin", "tokens": [3555, 38251, 21984, 34892, 5016, 27842, 34892, 5016, 32640, 8717, 14851, 24793, 1211, 20449, 3714, 5016, 46958, 25720, 13881, 385, 285, 30973, 4032, 2407, 36520, 8315, 5296, 17082, 995, 10632, 2423, 21587, 4032, 2423, 28356, 281, 21587], "avg_logprob": -0.11842105459225805, "compression_ratio": 1.256, "no_speech_prob": 0.0, "words": [{"start": 1.84, "end": 2.14, "word": "بسم", "probability": 0.85888671875}, {"start": 2.14, "end": 2.3, "word": " الله", "probability": 0.951171875}, {"start": 2.3, "end": 2.64, "word": " الرحمن", "probability": 0.9524739583333334}, {"start": 2.64, "end": 3.14, "word": " الرحيم", "probability": 0.994140625}, {"start": 3.14, "end": 4.44, "word": " نستكمل", "probability": 0.895751953125}, {"start": 4.44, "end": 4.6, "word": " مع", "probability": 0.96630859375}, 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"start": 16.69, "end": 42.47, "text": "الجسم ممكن ينتج antibody against the exogenous انسولين يعني الناس اللي بتعالجوا بالانسولين ممكن يصير في antibodies أو الجسم ينتج antibodies ضد هذا الانسولين وهذا بنطلق عليه exogenous insulin antibody syndrome", "tokens": [6027, 7435, 38251, 3714, 43020, 7251, 29399, 7435, 34507, 1970, 264, 454, 45519, 16472, 3794, 12610, 9957, 37495, 22653, 2423, 8315, 3794, 13672, 1829, 39894, 3615, 6027, 7435, 14407, 20666, 7649, 3794, 12610, 9957, 3714, 43020, 7251, 9381, 13546, 8978, 28356, 34051, 25724, 38251, 7251, 29399, 7435, 28356, 48812, 3215, 23758, 2423, 7649, 3794, 12610, 9957, 37037, 15730, 44945, 9566, 1211, 4587, 47356, 454, 45519, 21587, 34507, 19371], "avg_logprob": -0.09776947334192801, "compression_ratio": 1.6961325966850829, "no_speech_prob": 0.0, "words": [{"start": 16.69, "end": 17.39, "word": "الجسم", "probability": 0.9864908854166666}, {"start": 17.39, "end": 17.95, "word": " ممكن", "probability": 0.9912109375}, {"start": 17.95, "end": 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الاستخدام لـ recombinant insulin إلا أنه برضه يعني في ممكن يصير إنتاج ل antibodies against ال exogenous insulin", "tokens": [27842, 13672, 1829, 31439, 2423, 28356, 5296, 39184, 454, 45519, 21587, 44381, 11331, 49975, 20449, 2423, 1864, 3774, 18863, 6027, 1829, 4032, 11331, 49975, 20449, 42963, 14851, 9778, 3215, 10943, 5296, 39184, 850, 3548, 259, 394, 21587, 11933, 15040, 14739, 3224, 4724, 43042, 3224, 37495, 22653, 8978, 3714, 43020, 7251, 9381, 13546, 11933, 29399, 26108, 5296, 28356, 1970, 2423, 454, 45519, 21587], "avg_logprob": -0.20275297713658166, "compression_ratio": 1.5649717514124293, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 222.87, "end": 223.39, "word": "من", "probability": 0.96826171875}, {"start": 223.39, "end": 224.79, "word": " اللي", "probability": 0.78076171875}, {"start": 224.79, "end": 225.03, "word": " هو", "probability": 0.99072265625}, {"start": 225.03, "end": 225.37, "word": " ال", "probability": 0.98876953125}, {"start": 225.37, "end": 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267.94, "end": 268.52, "word": " antibodies", "probability": 0.9638671875}, {"start": 268.52, "end": 269.04, "word": " ضد", "probability": 0.985595703125}, {"start": 269.04, "end": 269.22, "word": " ال", "probability": 0.9853515625}, {"start": 269.22, "end": 269.82, "word": " exogenous", "probability": 0.8955078125}, {"start": 269.82, "end": 271.3, "word": " insulin", "probability": 0.98779296875}], "temperature": 1.0}, {"id": 13, "seek": 28825, "start": 272.29, "end": 288.25, "text": "يبقى عندنا زي اللي هو ال continuous subcutaneous insulin infusion أو أيضا في اللي هو ال inhaled insulin has resulted in significantly increased concentrations of insulin antibodies", "tokens": [1829, 3555, 4587, 7578, 43242, 8315, 30767, 1829, 13672, 1829, 31439, 2423, 10957, 1422, 6672, 15447, 21587, 1536, 5704, 34051, 36632, 11242, 995, 8978, 13672, 1829, 31439, 2423, 43157, 292, 21587, 575, 18753, 294, 10591, 6505, 33512, 295, 21587, 28356], "avg_logprob": -0.143197411444129, "compression_ratio": 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exogenous insulin أو لأ؟ يعني من التوصيات أنه مايصيرش فيه يعني routine يعني quantitation أو measurement لال insulin", "tokens": [3555, 15042, 7251, 2655, 30241, 4587, 20666, 2655, 2407, 9381, 1829, 9307, 23032, 1829, 3555, 8032, 1211, 7251, 9381, 13546, 8978, 7649, 995, 6156, 5016, 9381, 50113, 15040, 4724, 8592, 28820, 12602, 35473, 9957, 1829, 5296, 8315, 3794, 13672, 1829, 43242, 16095, 37495, 22653, 13881, 4032, 44945, 3615, 9566, 1829, 16095, 454, 45519, 21587, 34051, 5296, 10721, 22807, 37495, 22653, 9154, 16712, 2407, 9381, 1829, 9307, 14739, 3224, 19446, 1829, 9381, 13546, 8592, 8978, 3224, 37495, 22653, 9927, 37495, 22653, 4426, 4614, 34051, 13160, 5296, 6027, 21587], "avg_logprob": -0.16894531673328442, "compression_ratio": 1.5660377358490567, "no_speech_prob": 0.0, "words": [{"start": 315.26, "end": 315.62, "word": "بما", "probability": 0.95458984375}, {"start": 315.62, "end": 316.08, "word": " يتعلق", "probability": 0.983154296875}, {"start": 316.08, "end": 317.5, "word": " 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"seek": 39171, "start": 375.69, "end": 391.71, "text": "تمام، لأن الـ Antibodies مرتبط للإنسلين، وبالتالي الإنسلين مش هيقوم بعمله، والمشكلة التانية المتعلقة برضه بهذا الأمر، إن ارتباط الـ Antibodies بالإنسلين reversible", "tokens": [39237, 10943, 12399, 5296, 33456, 2423, 39184, 5130, 897, 6087, 3714, 43500, 3555, 9566, 24976, 28814, 1863, 3794, 1211, 9957, 12399, 46599, 6027, 2655, 6027, 1829, 33688, 1863, 3794, 1211, 9957, 37893, 39896, 4587, 20498, 4724, 25957, 43761, 12399, 16070, 2304, 8592, 28820, 3660, 16712, 7649, 10632, 9673, 2655, 30241, 28671, 4724, 43042, 3224, 39627, 15730, 16247, 29973, 12399, 36145, 1975, 43500, 3555, 41193, 2423, 39184, 5130, 897, 6087, 20666, 28814, 1863, 3794, 1211, 9957, 44788], "avg_logprob": -0.16213473948565396, "compression_ratio": 1.630952380952381, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 375.69, "end": 376.19, "word": "تمام،", "probability": 0.78564453125}, {"start": 376.19, "end": 376.35, "word": " لأن", "probability": 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بالـ Metabolism of Insulin Action التأثيرات المتعلقة بالإنسولين", "tokens": [1211, 19452, 8978, 43242, 8315, 11331, 6027, 3660, 6055, 7649, 10632, 3714, 43020, 29538, 2423, 39184, 5130, 897, 6087, 295, 264, 1300, 1336, 830, 6055, 8592, 2655, 17082, 1211, 9122, 39184, 2725, 266, 1751, 2725, 266, 1751, 7251, 3555, 4587, 7578, 8032, 2655, 8592, 2655, 17082, 1211, 9122, 33456, 3224, 33688, 1863, 3794, 12610, 9957, 31439, 9673, 43500, 3555, 9566, 46599, 6027, 2655, 6027, 1829, 23758, 39896, 33604, 16254, 30731, 11331, 3215, 2407, 12984, 5701, 2259, 328, 356, 26422, 654, 43242, 25124, 9778, 9381, 4724, 15042, 7251, 2655, 30241, 4587, 20666, 39184, 6377, 14923, 1434, 295, 9442, 17701, 16261, 16712, 10721, 12984, 13546, 9307, 9673, 2655, 30241, 28671, 20666, 28814, 1863, 3794, 12610, 9957], "avg_logprob": -0.14252717676370041, "compression_ratio": 1.5411764705882354, "no_speech_prob": 0.0, "words": [{"start": 535.96, "end": 536.42, "word": "لكن", "probability": 0.872314453125}, {"start": 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"text": "ليه الـ Insulin، ليه القيام بعمله؟ هو الإرتباط مع الـ receptor الخاص فيه على ال cell membrane يبقى بارتباط مع specific receptors على ال plasma membrane", "tokens": [20292, 3224, 2423, 39184, 9442, 17701, 12399, 32239, 3224, 25062, 1829, 10943, 4724, 25957, 43761, 22807, 31439, 33688, 43500, 3555, 41193, 20449, 2423, 39184, 32264, 33962, 33546, 8978, 3224, 15844, 2423, 2815, 19651, 7251, 3555, 4587, 7578, 4724, 9640, 2655, 3555, 41193, 20449, 2685, 34102, 15844, 2423, 22564, 19651], "avg_logprob": -0.24562501430511474, "compression_ratio": 1.489795918367347, "no_speech_prob": 4.76837158203125e-07, "words": [{"start": 594.96, "end": 595.76, "word": "ليه", "probability": 0.53302001953125}, {"start": 595.76, "end": 596.02, "word": " الـ", "probability": 0.812255859375}, {"start": 596.02, "end": 596.66, "word": " Insulin،", "probability": 0.6858723958333334}, {"start": 596.66, "end": 596.8, "word": " ليه", "probability": 0.973388671875}, {"start": 596.8, "end": 597.18, "word": " 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two beta sub units", "tokens": [2407, 3224, 15730, 2423, 39184, 9442, 17701, 32264, 39894, 30544, 9154, 5551, 25513, 3615, 1422, 6815, 46599, 6027, 2655, 6027, 1829, 31439, 6225, 3555, 9640, 3660, 18871, 3639, 2032, 23319, 44772, 897, 8497, 1451, 15577, 12399, 1451, 1422, 6815, 4032, 3224, 24192, 2423, 1422, 6815, 6225, 3555, 9640, 3660, 18871, 732, 8961, 293, 732, 9861, 1422, 6815], "avg_logprob": -0.2556573188510434, "compression_ratio": 1.44375, "no_speech_prob": 0.0, "words": [{"start": 611.65, "end": 612.51, "word": "وهذا", "probability": 0.8238932291666666}, {"start": 612.51, "end": 613.23, "word": " الـ", "probability": 0.6026611328125}, {"start": 613.23, "end": 613.69, "word": " Insulin", "probability": 0.830322265625}, {"start": 613.69, "end": 614.33, "word": " receptor", "probability": 0.5986328125}, {"start": 614.33, "end": 615.15, "word": " بتكون", "probability": 0.7109375}, {"start": 615.15, "end": 616.21, "word": " من", "probability": 0.9931640625}, {"start": 616.21, 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0.8466796875}, {"start": 786.36, "end": 787.72, "word": " مرة", "probability": 0.9921875}, {"start": 787.72, "end": 789.52, "word": " أخرى", "probability": 0.9920247395833334}, {"start": 789.52, "end": 790.54, "word": " طبعا", "probability": 0.9267578125}, {"start": 790.54, "end": 792.64, "word": " بالونهاية", "probability": 0.552337646484375}, {"start": 792.64, "end": 794.06, "word": " الـCascade", "probability": 0.752734375}, {"start": 794.06, "end": 794.5, "word": " هذا", "probability": 0.87109375}, {"start": 794.5, "end": 795.86, "word": " عندنا", "probability": 0.7386474609375}, {"start": 795.86, "end": 796.56, "word": " العديد", "probability": 0.98828125}, {"start": 796.56, "end": 797.0, "word": " من", "probability": 0.99560546875}, {"start": 797.0, "end": 799.92, "word": " الـmetabolic", "probability": 0.75714111328125}, {"start": 799.92, "end": 800.32, "word": " pathways", "probability": 0.204345703125}, {"start": 800.32, "end": 800.98, "word": " اللي", "probability": 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{"start": 879.09, "end": 879.45, "word": " شريح", "probability": 0.8515625}, {"start": 879.45, "end": 880.29, "word": " للكلام", "probability": 0.7261555989583334}, {"start": 880.29, "end": 880.43, "word": " اللي", "probability": 0.970458984375}, {"start": 880.43, "end": 880.93, "word": " حكيناه", "probability": 0.89970703125}, {"start": 880.93, "end": 881.13, "word": " بالـ", "probability": 0.870361328125}, {"start": 881.13, "end": 881.51, "word": " Slider", "probability": 0.94482421875}, {"start": 881.51, "end": 882.23, "word": " السابق", "probability": 0.81396484375}], "temperature": 1.0}, {"id": 39, "seek": 91278, "start": 883.62, "end": 912.78, "text": "من البروتينات اللي بيصلها activation بسبب ارتباط الانسولين فيها ان الـ Phosphotidylinositol-3-kinase اللي هو ده طبعا البروتين بتكون وفيها growth factor receptor bound البروتين اللي هو GRP2 وهدول الـ two proteins بيلعبوا دور مهم في نقل الـ signal إلى يعني داخل", "tokens": [27842, 2423, 26890, 35473, 9957, 9307, 13672, 1829, 4724, 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هو", "probability": 0.96337890625}, {"start": 901.56, "end": 902.58, "word": " GRP2", "probability": 0.73291015625}, {"start": 902.58, "end": 904.08, "word": " وهدول", "probability": 0.87255859375}, {"start": 904.08, "end": 904.5, "word": " الـ", "probability": 0.906982421875}, {"start": 904.5, "end": 904.7, "word": " two", "probability": 0.72265625}, {"start": 904.7, "end": 905.72, "word": " proteins", "probability": 0.378173828125}, {"start": 905.72, "end": 907.0, "word": " بيلعبوا", "probability": 0.94921875}, {"start": 907.0, "end": 907.28, "word": " دور", "probability": 0.99267578125}, {"start": 907.28, "end": 907.82, "word": " مهم", "probability": 0.989990234375}, {"start": 907.82, "end": 908.32, "word": " في", "probability": 0.97216796875}, {"start": 908.32, "end": 908.94, "word": " نقل", "probability": 0.9951171875}, {"start": 908.94, "end": 909.34, "word": " الـ", "probability": 0.803955078125}, {"start": 909.34, "end": 909.8, "word": " signal", "probability": 0.9130859375}, {"start": 909.8, "end": 910.84, "word": " إلى", "probability": 0.9375}, {"start": 910.84, "end": 911.88, "word": " يعني", "probability": 0.913818359375}, {"start": 911.88, "end": 912.78, "word": " داخل", "probability": 0.9801432291666666}], "temperature": 1.0}, {"id": 40, "seek": 93821, "start": 913.09, "end": 938.21, "text": "الخلية أيضًا برضه أنه الـ Signaling Pathway آخر اللي برضه مرتبط بارتباط الـ Insulin على الـ Receptors الـ Mitogen Activated Protein كينازي اللي هو الـ MAP كينازي و اللي بيشتغل من خلال ال activation للرأس أيضًا أن الـ PI3 زي ما قلنا", "tokens": [6027, 9778, 1211, 10632, 36632, 11242, 14111, 995, 4724, 43042, 3224, 14739, 3224, 2423, 39184, 13515, 4270, 21914, 676, 19753, 34740, 13672, 1829, 4724, 43042, 3224, 3714, 43500, 3555, 9566, 4724, 9640, 2655, 3555, 41193, 2423, 39184, 9442, 17701, 15844, 2423, 39184, 1300, 1336, 830, 2423, 39184, 10821, 8799, 28550, 770, 43371, 259, 9122, 1829, 8315, 11622, 1829, 13672, 1829, 31439, 2423, 39184, 376, 4715, 9122, 1829, 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اللي هي بتلعب دور مهم زي ما حكينا في الـ Translocation اللي بده يصير لجلوت Transporter بروتين وهذا الـ AKT بيشتغل من خلال الـ PDK1", "tokens": [3555, 3794, 43761, 24433, 4032, 31439, 47525, 13063, 3224, 4724, 1829, 25957, 1211, 24433, 5296, 39184, 24789, 51, 4032, 2423, 39184, 24789, 51, 13672, 1829, 39896, 39894, 1211, 3615, 3555, 11778, 13063, 3714, 16095, 30767, 1829, 19446, 11331, 4117, 1829, 8315, 8978, 2423, 39184, 6531, 5842, 399, 13672, 1829, 47525, 3224, 7251, 9381, 13546, 5296, 7435, 1211, 35473, 6531, 37356, 4724, 32887, 2655, 9957, 37037, 15730, 2423, 39184, 24789, 51, 4724, 1829, 8592, 2655, 17082, 1211, 9154, 16490, 1211, 6027, 2423, 39184, 10464, 42, 16], "avg_logprob": -0.1922238349568012, "compression_ratio": 1.5052083333333333, "no_speech_prob": 1.4901161193847656e-06, "words": [{"start": 938.82, "end": 939.62, "word": "بسله", "probability": 0.5804036458333334}, {"start": 939.62, "end": 940.18, "word": " activation", "probability": 0.82275390625}, {"start": 940.18, 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insulin ممكن يكون فيها بعض الاختلاف يبقى من tissue لآخر ممكن يكون فينا بعض الاختلاف اللي هو ناتج عن ارتباط ال insulin بهذه ال cells على سبيل المثال عندنا enescalatal muscle and adipose tissue", "tokens": [6027, 1802, 13672, 1829, 8032, 2655, 29399, 7435, 20666, 9778, 15040, 25528, 34051, 20666, 12404, 13672, 1829, 8032, 13546, 2655, 3555, 9566, 8978, 3224, 2423, 21587, 3714, 43020, 7251, 30544, 8978, 11296, 45030, 11242, 2423, 47283, 2655, 15040, 5172, 7251, 3555, 4587, 7578, 9154, 12404, 5296, 148, 95, 34740, 3714, 43020, 7251, 30544, 8978, 8315, 45030, 11242, 2423, 47283, 2655, 15040, 5172, 13672, 1829, 31439, 8717, 9307, 7435, 18871, 1975, 43500, 3555, 41193, 2423, 21587, 39627, 24192, 2423, 5438, 15844, 8608, 21292, 1211, 9673, 12984, 6027, 43242, 8315, 465, 279, 9895, 40478, 8679, 293, 614, 647, 541, 12404], "avg_logprob": -0.1360479813031476, "compression_ratio": 1.8364485981308412, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 966.19, "end": 966.51, "word": "ال", 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"text": "بما يتعلق بيه لـ Glucose Transport نقل الجلوكوز ودخوله إلى داخل الخلايا في عنا two families of proteins مسئولة عن هذا الأمر في عنا الـ Sodium Dependent Glucose Transporters الـ SGLT وفي عنا العائلة التانية", "tokens": [3555, 15042, 7251, 2655, 30241, 4587, 4724, 1829, 3224, 5296, 39184, 5209, 1311, 541, 22309, 8717, 4587, 1211, 25724, 1211, 2407, 4117, 2407, 11622, 4032, 3215, 9778, 12610, 3224, 30731, 11778, 47283, 1211, 33962, 15040, 25528, 8978, 6225, 8315, 732, 4466, 295, 15577, 47524, 19986, 12610, 3660, 18871, 23758, 16247, 29973, 8978, 6225, 8315, 2423, 39184, 42059, 2197, 4056, 521, 317, 5209, 1311, 541, 6531, 2816, 1559, 2423, 39184, 318, 19440, 51, 4032, 41185, 6225, 8315, 18863, 16373, 37977, 16712, 7649, 10632], "avg_logprob": -0.12932982107242905, "compression_ratio": 1.4975124378109452, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1111.18, "end": 1111.58, "word": "بما", "probability": 0.9541015625}, {"start": 1111.58, "end": 1112.08, "word": " يتعلق", "probability": 0.956298828125}, {"start": 1112.08, "end": 1112.36, "word": " بيه", "probability": 0.8165690104166666}, {"start": 1112.36, "end": 1112.58, "word": " لـ", "probability": 0.82373046875}, {"start": 1112.58, "end": 1113.1, "word": " Glucose", "probability": 0.859375}, {"start": 1113.1, "end": 1114.12, "word": " Transport", "probability": 0.87646484375}, {"start": 1114.12, "end": 1115.28, "word": " نقل", "probability": 0.8885091145833334}, {"start": 1115.28, "end": 1116.04, "word": " الجلوكوز", "probability": 0.8526204427083334}, {"start": 1116.04, "end": 1117.0, "word": " ودخوله", "probability": 0.97666015625}, {"start": 1117.0, "end": 1117.32, "word": " إلى", "probability": 0.9521484375}, {"start": 1117.32, "end": 1118.22, "word": " داخل", "probability": 0.9772135416666666}, {"start": 1118.22, "end": 1119.38, "word": " الخلايا", "probability": 0.9773763020833334}, {"start": 1119.38, "end": 1119.6, "word": " في", "probability": 0.43017578125}, {"start": 1119.6, 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هو الـ GLUT بيها دول العائلتين من البروتين أو من الـ Glucose Transporters مسئولين عن دخول الـ Glucose إلى داخل الخلايا النوع الأول Sodium Dependent Glucose Transporters", "tokens": [6027, 20292, 31439, 2423, 39184, 5209, 1311, 541, 6531, 2816, 1559, 34051, 17667, 388, 14275, 5209, 1311, 541, 6531, 2816, 1559, 13672, 1829, 31439, 2423, 39184, 16225, 8709, 4724, 1829, 11296, 11778, 12610, 18863, 16373, 1211, 2655, 9957, 9154, 2423, 26890, 35473, 9957, 34051, 9154, 2423, 39184, 5209, 1311, 541, 6531, 2816, 1559, 47524, 19986, 12610, 9957, 18871, 11778, 9778, 12610, 2423, 39184, 5209, 1311, 541, 30731, 11778, 47283, 1211, 33962, 15040, 25528, 28239, 45367, 16247, 12610, 42059, 2197, 4056, 521, 317, 5209, 1311, 541, 6531, 2816, 1559], "avg_logprob": -0.15036868647243198, "compression_ratio": 1.8162162162162163, "no_speech_prob": 4.172325134277344e-07, "words": [{"start": 1134.45, "end": 1135.23, "word": "اللي", "probability": 0.87353515625}, {"start": 1135.23, "end": 1135.51, "word": " هو", 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"end": 1142.39, "word": " بيها", "probability": 0.5558268229166666}, {"start": 1142.39, "end": 1142.75, "word": " دول", "probability": 0.987060546875}, {"start": 1142.75, "end": 1144.23, "word": " العائلتين", "probability": 0.9876953125}, {"start": 1144.23, "end": 1144.65, "word": " من", "probability": 0.9970703125}, {"start": 1144.65, "end": 1146.11, "word": " البروتين", "probability": 0.9241943359375}, {"start": 1146.11, "end": 1146.35, "word": " أو", "probability": 0.87255859375}, {"start": 1146.35, "end": 1146.53, "word": " من", "probability": 0.986328125}, {"start": 1146.53, "end": 1146.77, "word": " الـ", "probability": 0.83837890625}, {"start": 1146.77, "end": 1147.09, "word": " Glucose", "probability": 0.9537760416666666}, {"start": 1147.09, "end": 1147.79, "word": " Transporters", "probability": 0.91015625}, {"start": 1147.79, "end": 1148.61, "word": " مسئولين", "probability": 0.9173583984375}, {"start": 1148.61, "end": 1149.33, "word": " عن", "probability": 0.9951171875}, 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{"id": 100, "seek": 238506, "start": 2363.66, "end": 2385.06, "text": "are generating interest in the treatment of type 2 diabetes في عندنا أدوية وهذه عبارة عن GLB1 Analog تمام بيغير أنه ممكن تعمل release للإنسلين لكن برضه بتقلل من إنتاج الوالي glucose وأيضا بتقلل من ال uptake", "tokens": [543, 17746, 1179, 294, 264, 5032, 295, 2010, 568, 13881, 8978, 43242, 8315, 5551, 3215, 2407, 10632, 37037, 24192, 6225, 3555, 9640, 3660, 18871, 16225, 33, 16, 16128, 664, 46811, 10943, 4724, 1829, 17082, 13546, 14739, 3224, 3714, 43020, 6055, 25957, 1211, 4374, 24976, 28814, 1863, 3794, 1211, 9957, 44381, 4724, 43042, 3224, 39894, 4587, 1211, 1211, 9154, 11933, 29399, 26108, 2423, 2407, 6027, 1829, 23997, 36725, 1829, 11242, 995, 39894, 4587, 1211, 1211, 9154, 2423, 493, 27612], "avg_logprob": -0.26186709690697585, "compression_ratio": 1.3577981651376148, "no_speech_prob": 1.1920928955078125e-06, "words": [{"start": 2363.66, "end": 2364.02, "word": "are", "probability": 0.3037109375}, {"start": 2364.02, "end": 2364.62, "word": " generating", "probability": 0.91650390625}, {"start": 2364.62, "end": 2365.24, "word": " interest", "probability": 0.8720703125}, {"start": 2365.24, "end": 2365.48, "word": " in", "probability": 0.9697265625}, {"start": 2365.48, "end": 2365.62, "word": " the", "probability": 0.806640625}, {"start": 2365.62, "end": 2366.02, "word": " treatment", "probability": 0.93310546875}, {"start": 2366.02, "end": 2366.22, "word": " of", "probability": 0.97802734375}, {"start": 2366.22, "end": 2366.5, "word": " type", "probability": 0.947265625}, {"start": 2366.5, "end": 2366.8, "word": " 2", "probability": 0.68603515625}, {"start": 2366.8, "end": 2367.54, "word": " diabetes", "probability": 0.7119140625}, {"start": 2367.54, "end": 2368.6, "word": " في", "probability": 0.288330078125}, {"start": 2368.6, "end": 2369.42, "word": " عندنا", "probability": 0.880615234375}, {"start": 2369.42, "end": 2370.78, "word": " أدوية", "probability": 0.99169921875}, {"start": 2370.78, "end": 2371.32, "word": " وهذه", "probability": 0.4979248046875}, {"start": 2371.32, "end": 2371.62, "word": " عبارة", "probability": 0.985595703125}, {"start": 2371.62, "end": 2371.8, "word": " عن", "probability": 0.9775390625}, {"start": 2371.8, "end": 2373.04, "word": " GLB1", "probability": 0.60009765625}, {"start": 2373.04, "end": 2374.76, "word": " Analog", "probability": 0.39794921875}, {"start": 2374.76, "end": 2375.38, "word": " تمام", "probability": 0.872802734375}, {"start": 2375.38, "end": 2375.78, "word": " بيغير", "probability": 0.8660888671875}, {"start": 2375.78, "end": 2376.28, "word": " أنه", "probability": 0.691162109375}, {"start": 2376.28, "end": 2376.68, "word": " ممكن", "probability": 0.987060546875}, {"start": 2376.68, "end": 2377.34, "word": " تعمل", "probability": 0.9812825520833334}, {"start": 2377.34, "end": 2377.8, "word": " release", "probability": 0.84228515625}, {"start": 2377.8, "end": 2378.52, "word": " للإنسلين", "probability": 0.7047526041666666}, {"start": 2378.52, "end": 2378.82, "word": " لكن", "probability": 0.9501953125}, {"start": 2378.82, "end": 2379.3, "word": " برضه", "probability": 0.9739583333333334}, {"start": 2379.3, "end": 2380.32, "word": " بتقلل", "probability": 0.978515625}, {"start": 2380.32, "end": 2380.46, "word": " من", "probability": 0.99462890625}, {"start": 2380.46, "end": 2381.1, "word": " إنتاج", "probability": 0.94873046875}, {"start": 2381.1, "end": 2381.58, "word": " الوالي", "probability": 0.7042236328125}, {"start": 2381.58, "end": 2381.92, "word": " glucose", "probability": 0.44482421875}, {"start": 2381.92, "end": 2382.78, "word": " وأيضا", "probability": 0.8319091796875}, {"start": 2382.78, "end": 2383.36, "word": " بتقلل", "probability": 0.972412109375}, {"start": 2383.36, "end": 2383.66, "word": " من", "probability": 0.9931640625}, {"start": 2383.66, "end": 2384.48, "word": " ال", "probability": 0.966796875}, {"start": 2384.48, "end": 2385.06, "word": " uptake", "probability": 0.28466796875}], "temperature": 1.0}, {"id": 101, "seek": 240244, "start": 2386.12, "end": 2402.44, "text": "وفي أربع أدوية يعني تم إنتاجها وحصلت على الـ Approval من الـ Food and Drug Administration لإستعمالها مع مرضى Type 2 Diabetes Mellitus", "tokens": [38688, 1829, 5551, 25513, 3615, 5551, 3215, 2407, 10632, 37495, 22653, 46811, 11933, 29399, 26108, 11296, 4032, 5016, 36520, 2655, 15844, 2423, 39184, 29551, 3337, 9154, 2423, 39184, 11675, 293, 35806, 17187, 5296, 28814, 14851, 25957, 6027, 11296, 20449, 3714, 43042, 7578, 15576, 568, 8789, 12632, 1923, 285, 30973], "avg_logprob": -0.16468750178813935, "compression_ratio": 1.144578313253012, "no_speech_prob": 0.0, "words": [{"start": 2386.12, "end": 2387.06, "word": "وفي", "probability": 0.928955078125}, {"start": 2387.06, "end": 2387.88, "word": " أربع", "probability": 0.8590494791666666}, {"start": 2387.88, "end": 2388.82, "word": " أدوية", "probability": 0.991455078125}, {"start": 2388.82, "end": 2389.66, "word": " يعني", "probability": 0.6566162109375}, {"start": 2389.66, "end": 2390.24, "word": " تم", "probability": 0.9873046875}, {"start": 2390.24, "end": 2390.88, "word": " إنتاجها", "probability": 0.89990234375}, {"start": 2390.88, "end": 2391.66, "word": " وحصلت", "probability": 0.9710693359375}, {"start": 2391.66, "end": 2392.04, "word": " على", "probability": 0.94775390625}, {"start": 2392.04, "end": 2393.6, "word": " الـ", "probability": 0.89306640625}, {"start": 2393.6, "end": 2394.2, "word": " Approval", "probability": 0.695068359375}, {"start": 2394.2, "end": 2394.42, "word": " من", "probability": 0.98876953125}, {"start": 2394.42, "end": 2394.62, "word": " الـ", "probability": 0.899169921875}, {"start": 2394.62, "end": 2394.9, "word": " Food", "probability": 0.87841796875}, {"start": 2394.9, "end": 2395.24, "word": " and", "probability": 0.91064453125}, {"start": 2395.24, "end": 2395.6, "word": " Drug", "probability": 0.96240234375}, {"start": 2395.6, "end": 2396.68, "word": " Administration", "probability": 0.98193359375}, {"start": 2396.68, "end": 2398.78, "word": " لإستعمالها", "probability": 0.8448079427083334}, {"start": 2398.78, "end": 2399.06, "word": " مع", "probability": 0.99169921875}, {"start": 2399.06, "end": 2399.7, "word": " مرضى", "probability": 0.986328125}, {"start": 2399.7, "end": 2400.34, "word": " Type", "probability": 0.75341796875}, {"start": 2400.34, "end": 2400.58, "word": " 2", "probability": 0.6572265625}, {"start": 2400.58, "end": 2401.42, "word": " Diabetes", "probability": 0.7568359375}, {"start": 2401.42, "end": 2402.44, "word": " Mellitus", "probability": 0.6803385416666666}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2404.937125, "duration_after_vad": 2301.85562499999}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/wNcigeivKdA_raw.srt b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/wNcigeivKdA_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..81ac8b46508dcf95c5adf1eb124a52b91e4fecc1
--- /dev/null
+++ b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/wNcigeivKdA_raw.srt
@@ -0,0 +1,1848 @@
+1
+00:00:01,840 --> 00:00:06,080
+بسم الله الرحمن الرحيم نستكمل مع محاضرة diabetes
+
+2
+00:00:06,080 --> 00:00:12,940
+mellitus ووصلنا لغاية ال insulin و ال antibodies
+
+3
+00:00:12,940 --> 00:00:14,260
+to insulin
+
+4
+00:00:16,690 --> 00:00:22,170
+الجسم ممكن ينتج antibody against the exogenous
+
+5
+00:00:22,170 --> 00:00:29,850
+انسولين يعني الناس اللي بتعالجوا بالانسولين ممكن
+
+6
+00:00:29,850 --> 00:00:34,950
+يصير في antibodies أو الجسم ينتج antibodies ضد هذا
+
+7
+00:00:34,950 --> 00:00:40,550
+الانسولين وهذا بنطلق عليه exogenous insulin
+
+8
+00:00:40,550 --> 00:00:42,470
+antibody syndrome
+
+9
+00:00:44,970 --> 00:00:48,690
+الـ these antibodies are usually present at low
+
+10
+00:00:48,690 --> 00:00:52,410
+titers يبقى ال concentration لل antibodies هذي
+
+11
+00:00:52,410 --> 00:00:59,230
+بتكون قليلة ويعني مابيكونش في عنا أي نتائج يعني
+
+12
+00:00:59,230 --> 00:01:05,350
+عكسية on real .. real occasions high titers of
+
+13
+00:01:05,350 --> 00:01:08,850
+insulin antibodies may cause insulin resistance
+
+14
+00:01:10,760 --> 00:01:17,380
+وهذا بيصير بشكل خاص في الناس اللي عندهم type 2
+
+15
+00:01:17,380 --> 00:01:21,160
+diabetes mellitus و اللي يعني بالمراحل متقدمة من
+
+16
+00:01:21,160 --> 00:01:29,600
+المرض و اللي بدوا ياخدوا insulin ضمن العلاج يبقى
+
+17
+00:01:29,600 --> 00:01:34,100
+بهذه الحالة ممكن يصير فينا ارتفاع في ال
+
+18
+00:01:34,100 --> 00:01:40,730
+concentrations لل insulin antibodiesو هذا الارتفاع
+
+19
+00:01:40,730 --> 00:01:44,890
+سيؤدي إلى insulin resistance
+
+20
+00:01:46,610 --> 00:01:50,570
+كيف يتم التعامل مع هدول المرضى؟ فيه أنه several
+
+21
+00:01:50,570 --> 00:01:54,750
+therapeutic approaches for treating these patients
+
+22
+00:01:54,750 --> 00:01:58,110
+ومن ضمن ال approaches أنه يصير فيه double
+
+23
+00:01:58,110 --> 00:02:04,670
+filtration بلازمافوريس أو يصير فيه plasma exchange
+
+24
+00:02:04,670 --> 00:02:11,110
+لمدة two weeks بالإضافة لـأعطاه هدول المرضى
+
+25
+00:02:11,110 --> 00:02:17,630
+prednisolone اللي هو synthetic hydrocortisone وهذا
+
+26
+00:02:17,630 --> 00:02:21,350
+طبعا اللي هو هيعمل على يعني تقليل ال immune
+
+27
+00:02:21,350 --> 00:02:23,030
+response
+
+28
+00:02:24,740 --> 00:02:29,660
+أيضا في هذه الحالات انه يعني يضل فينا متابع ويعني
+
+29
+00:02:29,660 --> 00:02:35,540
+يتم عمل ال quantitative estimate لإن ال
+
+30
+00:02:35,540 --> 00:02:39,300
+concentration of the circulating insulin
+
+31
+00:02:39,300 --> 00:02:42,980
+antibodies does not appear to be of significant
+
+32
+00:02:42,980 --> 00:02:46,940
+benefit يعني مش هيفيدكتير ما زال عارفنا أنه في
+
+33
+00:02:46,940 --> 00:02:51,100
+عندنا antibodies و ال antibodies هذه يعني إلها
+
+34
+00:02:51,100 --> 00:02:54,240
+مفعول
+
+35
+00:02:54,240 --> 00:02:58,100
+أو ممكن .. ممكن تزيد من ال insulin resistance يبقى
+
+36
+00:02:58,100 --> 00:03:02,680
+بهذه الحالة زي ما قلنا بدنا اللي هو يعني يكون في
+
+37
+00:03:02,680 --> 00:03:08,300
+عندنا therapeutic approach و يتم التعامل مع المريض
+
+38
+00:03:08,300 --> 00:03:11,240
+من خلال اللي ذكرناه
+
+39
+00:03:13,520 --> 00:03:17,700
+التحسين في صحيحة الإنسولين الحيواني وإنسولين
+
+40
+00:03:17,700 --> 00:03:22,540
+الحيواني المتوسط قد أقل، ولكن ليس تقليلاً عن إنتاج
+
+41
+00:03:22,540 --> 00:03:29,320
+الإنسولين الحيواني يبقى مع الإنتاج للإنسولين
+
+42
+00:03:29,320 --> 00:03:33,680
+الحيواني وطبعاً يعني صار في ان اعتماد أقل على
+
+43
+00:03:33,680 --> 00:03:38,800
+الإنسولين الحيواني والصحيحة اللي بتصير درجة عالية
+
+44
+00:03:38,800 --> 00:03:45,370
+للإنسولين هذه قللت بشكل كبيرمن اللي هو ال
+
+45
+00:03:45,370 --> 00:03:49,130
+antibodies لـ
+
+46
+00:03:49,130 --> 00:03:53,490
+exogenous insulin لكن حتى مع ال purification
+
+47
+00:03:53,490 --> 00:03:59,990
+العالي و حتى مع الاستخدام لـ recombinant insulin
+
+48
+00:03:59,990 --> 00:04:04,770
+إلا أنه برضه يعني في ممكن يصير إنتاج ل antibodies
+
+49
+00:04:04,770 --> 00:04:12,820
+against ال exogenous insulinالاستخدام ليه يعني
+
+50
+00:04:12,820 --> 00:04:19,180
+ممكن نقول ال less invasive يعني ways او delivery
+
+51
+00:04:19,180 --> 00:04:27,940
+system لأ ال insulin للأسف هذه زادت من إنتاج ال
+
+52
+00:04:27,940 --> 00:04:33,110
+antibodies ضد ال exogenous insulinيبقى عندنا زي
+
+53
+00:04:33,110 --> 00:04:35,850
+اللي هو ال continuous subcutaneous insulin
+
+54
+00:04:35,850 --> 00:04:42,810
+infusion أو أيضا في اللي هو ال inhaled insulin has
+
+55
+00:04:42,810 --> 00:04:45,770
+resulted in significantly increased concentrations
+
+56
+00:04:45,770 --> 00:04:48,250
+of insulin antibodies
+
+57
+00:04:51,430 --> 00:04:54,630
+Antibodies to insulin really develop in patients
+
+58
+00:04:54,630 --> 00:04:58,770
+who have not received exogenous insulin يبقى
+
+59
+00:04:58,770 --> 00:05:03,870
+المشكلة الأساسية هو بالExogenous insulin يبقى لما
+
+60
+00:05:03,870 --> 00:05:08,030
+يصير في administration لExogenous insulin ممكن
+
+61
+00:05:08,030 --> 00:05:12,030
+تبدأ تتكون Antibodies ضد الانسلين
+
+62
+00:05:15,260 --> 00:05:19,820
+بما يتعلق بالتوصيات طيب هل يصير فيانا فحص مثلا
+
+63
+00:05:19,820 --> 00:05:26,120
+بشكل روتيني لناس اللي عندهم يعني diabetes و
+
+64
+00:05:26,120 --> 00:05:32,500
+بنعطيهم exogenous insulin أو لأ؟ يعني من التوصيات
+
+65
+00:05:32,500 --> 00:05:40,120
+أنه مايصيرش فيه يعني routine يعني quantitation أو
+
+66
+00:05:40,120 --> 00:05:45,670
+measurement لال insulinولكن ليس هناك اثارة لإدارة
+
+67
+00:05:45,670 --> 00:05:50,090
+استخدام الانسلين للتجارب للطبيعي للطبيعي للطيابين
+
+68
+00:05:50,090 --> 00:05:51,690
+اللي بيبتس
+
+69
+00:05:54,020 --> 00:05:58,740
+طبعا زي ما قولنا إنه من المشكلات اللي ممكن تنتج عن
+
+70
+00:05:58,740 --> 00:06:03,760
+وجود ال antibodies هذه وارتباطها مع الانسلين هو
+
+71
+00:06:03,760 --> 00:06:08,920
+حدوث الانسلين resistance وبالتالي هذا هيؤدي إلى
+
+72
+00:06:08,920 --> 00:06:16,350
+ارتفاع في ال postprandial blood glucoseتمام، لأن
+
+73
+00:06:16,350 --> 00:06:20,470
+الـ Antibodies مرتبط للإنسلين، وبالتالي الإنسلين
+
+74
+00:06:20,470 --> 00:06:25,010
+مش هيقوم بعمله، والمشكلة التانية المتعلقة برضه
+
+75
+00:06:25,010 --> 00:06:30,530
+بهذا الأمر، إن ارتباط الـ Antibodies بالإنسلين
+
+76
+00:06:30,530 --> 00:06:34,870
+reversibleلما بيجي ال antibody مش هيضال مرتبط لو
+
+77
+00:06:34,870 --> 00:06:40,070
+تغيرت الظروف ممكن يفك الإرتباط بين ال insulin و
+
+78
+00:06:40,070 --> 00:06:43,470
+بين ال antibody وبالتالي هذا ممكن يزيد من ال
+
+79
+00:06:43,470 --> 00:06:48,410
+insulin concentration اللي موجودة بالدم وهذا اللي
+
+80
+00:06:48,410 --> 00:06:54,430
+ممكن يصير at night التغير فيهالـ pH at night ممكن
+
+81
+00:06:54,430 --> 00:06:59,670
+يعمل dissociation بين الإنسلين وبين الـ antibody
+
+82
+00:06:59,670 --> 00:07:04,930
+اللي كان مرتبط معاه وبالتالي يزيد من الـ ال
+
+83
+00:07:04,930 --> 00:07:08,690
+concentration للإنسلين وبالتالي ممكن يؤدي إلى
+
+84
+00:07:08,690 --> 00:07:14,490
+hypoglycemia أنها مشكلة تانية بتتعلق بال
+
+85
+00:07:14,490 --> 00:07:18,770
+antibodies هو إنتاج antibodies ضد الإنسلين
+
+86
+00:07:18,770 --> 00:07:27,650
+receptorوفي هذه الحالة أنه ممكن ينبج مشكلتين ال
+
+87
+00:07:27,650 --> 00:07:32,190
+antibodies هذه اللي هترتبط مع ال receptor ممكن
+
+88
+00:07:32,190 --> 00:07:38,350
+تشتغل ك antagonist وإذا اشتغلت ك antagonist معناه
+
+89
+00:07:38,350 --> 00:07:41,690
+طبعا هيصير فيه competition بينها و بين ال ال
+
+90
+00:07:41,690 --> 00:07:44,670
+insulin و هي هترتبط مع ال receptor و تمنع من
+
+91
+00:07:44,670 --> 00:07:51,820
+ارتباطالانسولين و هتؤدي الى حدوث hyperglycemia
+
+92
+00:07:51,820 --> 00:07:57,300
+وهذا اللى بيشوفوه فى حالات ال patients with
+
+93
+00:07:57,300 --> 00:08:05,080
+acanthosis negligens اللى بيكون فى اللى هو يعني زى
+
+94
+00:08:05,080 --> 00:08:10,960
+epidermal skin cells begin to reproduce rapidly
+
+95
+00:08:10,960 --> 00:08:18,040
+فبصير فى تكاثر لخلايا بشكل كبيرو هذا بيعمل اللي هو
+
+96
+00:08:18,040 --> 00:08:23,320
+ال skin growth و بيبين اللي هو بالشكل زي اللي هو
+
+97
+00:08:23,320 --> 00:08:29,490
+الصورة دي سواء تحت القبض أو على اللي هو الرقبةوهذا
+
+98
+00:08:29,490 --> 00:08:32,850
+زي ما قلنا بيكون بسبب أنه في عندي antibodies ضد ال
+
+99
+00:08:32,850 --> 00:08:40,110
+receptors وهذا بيمنع من ارتباط ال .. ال insulin
+
+100
+00:08:40,110 --> 00:08:45,890
+وبي .. هذا بيقدر إلى رفع مستويات ال insulin في
+
+101
+00:08:45,890 --> 00:08:50,870
+الجسم وبالتالي abnormal اللي هو skin cell growth
+
+102
+00:08:50,870 --> 00:08:55,470
+بهذا في حال أنه ال antibodies اشتغلت ك antagonist
+
+103
+00:08:55,960 --> 00:08:59,320
+لكن في عندنا حالة تانية ممكن هذه الـ Antibodies of
+
+104
+00:08:59,320 --> 00:09:03,320
+the Receptors تشتغل كـ Agonists Agonists يبقى
+
+105
+00:09:03,320 --> 00:09:09,260
+هتشتغل كأنه الإنسولين هو المرتبط وبالتالي هذا
+
+106
+00:09:09,260 --> 00:09:17,660
+هيؤدي إلى حدوث Hypoiglycemia عند الشخص بما يتعلق
+
+107
+00:09:17,660 --> 00:09:22,520
+بالـ Metabolism of Insulin Action التأثيرات
+
+108
+00:09:22,520 --> 00:09:29,320
+المتعلقة بالإنسولينيعني نوعًا ما باتت معروفة
+
+109
+00:09:29,320 --> 00:09:34,260
+ومفهومة يبقى الـ metabolic effects المختلفة لكن
+
+110
+00:09:34,260 --> 00:09:39,220
+على مستوى الـ molecular mechanism وكيف الـ Insulin
+
+111
+00:09:39,220 --> 00:09:44,300
+بيعمل هذه اللي هو التأثيرات المختلفة ويؤدي إلى الـ
+
+112
+00:09:44,300 --> 00:09:48,560
+different metabolic effects يعني ما زالت تحتاج إلى
+
+113
+00:09:48,560 --> 00:09:56,660
+مزيد من الفهم أكيد الخطوة الأولىليه الـ Insulin،
+
+114
+00:09:56,660 --> 00:09:59,920
+ليه القيام بعمله؟ هو الإرتباط مع الـ receptor
+
+115
+00:09:59,920 --> 00:10:06,020
+الخاص فيه على ال cell membrane يبقى بارتباط مع
+
+116
+00:10:06,020 --> 00:10:13,230
+specific receptors على ال plasma membraneوهذا الـ
+
+117
+00:10:13,230 --> 00:10:19,850
+Insulin receptor بتكون من أربع sub units وبالتالي
+
+118
+00:10:19,850 --> 00:10:25,030
+هو عبارة عن hetero tetrameribiana four proteins،
+
+119
+00:10:25,030 --> 00:10:28,570
+four sub units وهذه ال sub units عبارة عن two
+
+120
+00:10:28,570 --> 00:10:36,500
+alpha and two beta sub unitsالـ Alpha subunit is
+
+121
+00:10:36,500 --> 00:10:39,260
+located on the outer surface of the plasma
+
+122
+00:10:39,260 --> 00:10:45,180
+membrane and contains the site where insulin binds
+
+123
+00:10:45,180 --> 00:10:50,000
+وزي ما وضعنا بيه ال figure زي ما قولنا أن الـ
+
+124
+00:10:50,000 --> 00:10:55,460
+Alpha subunits هي اللي موجودة على اللواء الخارج من
+
+125
+00:10:55,460 --> 00:11:01,000
+ال receptor و هذه ال subunits اللي بيرتبط معها ال
+
+126
+00:11:01,000 --> 00:11:07,230
+insulin و ال beta subunitsعنا هذا اللي هو الـ
+
+127
+00:11:07,230 --> 00:11:10,150
+polypeptide فى جزء منه اللي هو الـ transmembrane
+
+128
+00:11:10,150 --> 00:11:17,950
+وفى عنا جزء اللي هو الـ cytoplasmic domain وارتباط
+
+129
+00:11:17,950 --> 00:11:23,550
+الإنسولين هذا يؤدي إلى حدوث confirmation of change
+
+130
+00:11:23,550 --> 00:11:31,450
+بيه الـ beta sub unitsوالـ Insulin receptor يُعتبر
+
+131
+00:11:31,450 --> 00:11:40,430
+subfamily من الـ receptor tyrosine kinases وما زال
+
+132
+00:11:40,430 --> 00:11:46,150
+بنحكي على kinase يبقى هذا الـ البروتين هيعمل على
+
+133
+00:11:46,150 --> 00:11:52,540
+اللي هو الـ phosphorylation ل other proteinsوهذا
+
+134
+00:11:52,540 --> 00:11:56,260
+فعليًا اللي بيصير ارتباط الـ Insulin مع الـ Alpha
+
+135
+00:11:56,260 --> 00:11:59,140
+-subunit بيعمل confirmation and change في الـ Beta
+
+136
+00:11:59,140 --> 00:12:03,940
+-subunits ويؤدي إلى auto phosphorylation لـ Beta
+
+137
+00:12:03,940 --> 00:12:08,800
+-subunits وبالتالي هذا يؤدي إلى recruitment لـ
+
+138
+00:12:08,800 --> 00:12:13,960
+other cytoplasmic proteins to be phosphorylatedالـ
+
+139
+00:12:13,960 --> 00:12:17,320
+Phosphorylation بيستدعى بروتينات أخرى، وهذه
+
+140
+00:12:17,320 --> 00:12:21,220
+البروتينات الأخرى هيصلها Phosphorylation عن طريق
+
+141
+00:12:21,220 --> 00:12:26,400
+اللي هو الـ Active Tyrosine Kinase اللي هو الخاص
+
+142
+00:12:26,400 --> 00:12:31,890
+بالـ Receptorيبقى زي ما قلنا الـ Phosphorylation
+
+143
+00:12:31,890 --> 00:12:37,390
+لـ الـ الـ cytoplasmic domain لـ الـ Beta-subunit
+
+144
+00:12:37,390 --> 00:12:42,190
+بيستدعي بروتينات أخرى زي الـ SHC و بيصلها
+
+145
+00:12:42,190 --> 00:12:47,390
+Phosphorylation و عندنا أيضًا بروتين آخر اللي هو
+
+146
+00:12:47,390 --> 00:12:52,370
+الـ IRS Insulin Receptor Substrate هذه البروتينات
+
+147
+00:12:52,370 --> 00:12:57,660
+بيصلها Phosphorylationوبعد هيك هذه البروتينات
+
+148
+00:12:57,660 --> 00:13:03,780
+بترتبط مع بروتينات أخرى موجودة في الـCytoplasm
+
+149
+00:13:03,780 --> 00:13:12,640
+وبتعمللها activation مرة أخرى طبعا بالونهاية
+
+150
+00:13:12,640 --> 00:13:19,920
+الـCascade هذا عندنا العديد من الـmetabolic
+
+151
+00:13:19,920 --> 00:13:25,340
+pathways اللي طبعا مرتبطة بالأساس بوجود الانشلين
+
+152
+00:13:25,560 --> 00:13:30,340
+ومنها عنا على سبيل المثال الـ cell growth و
+
+153
+00:13:30,340 --> 00:13:34,140
+differentiation في عنا اللي هو الـ protein
+
+154
+00:13:34,140 --> 00:13:37,980
+synthesis في عنا الـ glycogen synthesis في عنا
+
+155
+00:13:37,980 --> 00:13:44,300
+المنع للـ gluconeogenesis وعنا أيضا زيادة الـ
+
+156
+00:13:44,300 --> 00:13:51,490
+lipogenesisأيضًا بالإضافة إلى الـ Translocation
+
+157
+00:13:51,490 --> 00:13:56,970
+اللي بيصير لواحدة من البروتين الـ transporters
+
+158
+00:13:56,970 --> 00:14:01,310
+الخاصة بالجلوكوز الوزيق والجلوت، يعني هذا البروتين
+
+159
+00:14:01,310 --> 00:14:07,030
+بيكون في داخل الـ cytoplasm ومع ارتباط الانسلين
+
+160
+00:14:07,030 --> 00:14:11,110
+بيصير في عندنا Translocation وبيبدأ طبعًا بفعل
+
+161
+00:14:11,110 --> 00:14:18,150
+اللي هو البروتين يسمى AKTيبقى هذا بيؤدي إلى حدوث
+
+162
+00:14:18,150 --> 00:14:22,690
+Translocation للجلوت اللي موجودة كانت في داخل الـ
+
+163
+00:14:22,690 --> 00:14:27,310
+Cytoplasm وارتباطها
+
+164
+00:14:27,310 --> 00:14:33,770
+بالـ Cell Membrane للسماح بأكتر الـ Glucose للدخول
+
+165
+00:14:33,770 --> 00:14:40,430
+إلى الخلية هذه الـ Slider اللي هو شريح للكلام اللي
+
+166
+00:14:40,430 --> 00:14:45,500
+حكيناه بالـ Slider السابقمن البروتينات اللي بيصلها
+
+167
+00:14:45,500 --> 00:14:51,040
+activation بسبب ارتباط الانسولين فيها ان الـ
+
+168
+00:14:51,040 --> 00:14:55,540
+Phosphotidylinositol-3-kinase اللي هو ده طبعا
+
+169
+00:14:55,540 --> 00:15:00,940
+البروتين بتكون وفيها growth factor receptor bound
+
+170
+00:15:00,940 --> 00:15:05,720
+البروتين اللي هو GRP2 وهدول الـ two proteins
+
+171
+00:15:05,720 --> 00:15:12,780
+بيلعبوا دور مهم في نقل الـ signal إلى يعني داخل
+
+172
+00:15:13,090 --> 00:15:18,550
+الخلية أيضًا برضه أنه الـ Signaling Pathway آخر
+
+173
+00:15:18,550 --> 00:15:22,370
+اللي برضه مرتبط بارتباط الـ Insulin على الـ
+
+174
+00:15:22,370 --> 00:15:26,530
+Receptors الـ Mitogen Activated Protein كينازي
+
+175
+00:15:26,530 --> 00:15:31,370
+اللي هو الـ MAP كينازي و اللي بيشتغل من خلال ال
+
+176
+00:15:31,370 --> 00:15:39,620
+activation للرأس أيضًا أن الـ PI3 زي ما قلنابسله
+
+177
+00:15:39,620 --> 00:15:45,200
+activation و هو بدوره بيعمل activation لـ AKT و
+
+178
+00:15:45,200 --> 00:15:51,820
+الـ AKT اللي هي بتلعب دور مهم زي ما حكينا في الـ
+
+179
+00:15:51,820 --> 00:15:57,160
+Translocation اللي بده يصير لجلوت Transporter
+
+180
+00:15:57,160 --> 00:16:04,420
+بروتين وهذا الـ AKT بيشتغل من خلال الـ PDK1
+
+181
+00:16:06,190 --> 00:16:12,070
+ال effect اللي هتنتج بالخلايا أو بال tissue اللي
+
+182
+00:16:12,070 --> 00:16:17,390
+هيرتبط فيه ال insulin ممكن يكون فيها بعض الاختلاف
+
+183
+00:16:17,390 --> 00:16:22,090
+يبقى من tissue لآخر ممكن يكون فينا بعض الاختلاف
+
+184
+00:16:22,090 --> 00:16:28,910
+اللي هو ناتج عن ارتباط ال insulin بهذه ال cells
+
+185
+00:16:28,910 --> 00:16:33,790
+على سبيل المثال عندنا enescalatal muscle and
+
+186
+00:16:33,790 --> 00:16:37,680
+adipose tissueالـ AKT تقوم بتحريك التحريك
+
+187
+00:16:37,680 --> 00:16:43,180
+الجلوكوزي بمشاركة التحريك الجلوكوزي لـ GLUT4 كما
+
+188
+00:16:43,180 --> 00:16:48,160
+قلت، تحريك الجلوكوزي لـ GLUT4 يكون موجود في داخل
+
+189
+00:16:48,160 --> 00:16:52,600
+الـ cytoplasm و بسله التحريك الجلوكوزي و بيرطبط مع
+
+190
+00:16:52,600 --> 00:17:00,080
+الـ cell membrane عشان يسمح بدخول الجلوكوزي في الـ
+
+191
+00:17:00,080 --> 00:17:08,140
+liver الـ AKT تفسفوريلاتand inactivates GSK3β الـ
+
+192
+00:17:08,140 --> 00:17:14,920
+glycogen synthase kinase 3β وبالتالي هذا بيؤدي إلى
+
+193
+00:17:14,920 --> 00:17:22,400
+enhancing the glycogen synthesis طبعا
+
+194
+00:17:22,400 --> 00:17:30,380
+ال GSK3β هو عبارة عن inhibitor لل glycogen
+
+195
+00:17:30,380 --> 00:17:34,780
+synthaseأو inactivating agent للـ glycogen
+
+196
+00:17:34,780 --> 00:17:39,680
+synthase اللي هو ال .. ال .. ال enzyme اللي بيلعب
+
+197
+00:17:39,680 --> 00:17:43,600
+دور في عملية ال synthesis لل glycogen لما احنا
+
+198
+00:17:43,600 --> 00:17:48,940
+بنعمل inactivation لل GSK3β تماما بيجيب نعمل
+
+199
+00:17:48,940 --> 00:17:53,000
+inhibition لل inhibitor وبالتالي هيصير في عنا
+
+200
+00:17:53,000 --> 00:17:58,620
+active glycogen synthase وبالتالي glycogen
+
+201
+00:17:58,620 --> 00:18:05,240
+synthesisالـ AKT أيضًا تخلص الـ gluconeogenesis
+
+202
+00:18:05,240 --> 00:18:09,340
+لأنه احنا عندنا موجود كميات كبيرة من الجلوكوز
+
+203
+00:18:09,340 --> 00:18:14,560
+وبالتالي احنا مش في حاجة انه نصنع الجلوكوز من
+
+204
+00:18:14,560 --> 00:18:19,020
+مصادر اللي و غير كربوهيدراتية تمام؟ يبقى بيصير في
+
+205
+00:18:19,020 --> 00:18:23,820
+عندنا suppression لل gluconeogenesis و بالمقابل
+
+206
+00:18:23,820 --> 00:18:28,040
+بيصير في عندنا activation لل lipogenesis in the
+
+207
+00:18:28,040 --> 00:18:28,440
+liver
+
+208
+00:18:31,180 --> 00:18:36,040
+بما يتعلق بيه لـ Glucose Transport نقل الجلوكوز
+
+209
+00:18:36,040 --> 00:18:41,080
+ودخوله إلى داخل الخلايا في عنا two families of
+
+210
+00:18:41,080 --> 00:18:46,060
+proteins مسئولة عن هذا الأمر في عنا الـ Sodium
+
+211
+00:18:46,060 --> 00:18:51,680
+Dependent Glucose Transporters الـ SGLT وفي عنا
+
+212
+00:18:51,680 --> 00:18:58,410
+العائلة التانيةاللي هو الـ Glucose Transporters أو
+
+213
+00:18:58,410 --> 00:19:01,430
+Facilitative Glucose Transporters اللي هو الـ GLUT
+
+214
+00:19:01,430 --> 00:19:07,090
+بيها دول العائلتين من البروتين أو من الـ Glucose
+
+215
+00:19:07,090 --> 00:19:12,070
+Transporters مسئولين عن دخول الـ Glucose إلى داخل
+
+216
+00:19:12,070 --> 00:19:16,750
+الخلايا النوع الأول Sodium Dependent Glucose
+
+217
+00:19:16,750 --> 00:19:21,080
+Transportersهذه بتستخدم اللي هو الـ
+
+218
+00:19:21,080 --> 00:19:25,360
+Electrochemical Sodium Gradient To Transport
+
+219
+00:19:25,360 --> 00:19:30,860
+Glucose Against Its Concentration Gradient وهذا
+
+220
+00:19:30,860 --> 00:19:39,000
+البروتين فعلياً بيعمل على نقل ال Sodium ومع ال
+
+221
+00:19:39,000 --> 00:19:45,020
+Sodium أيضاً بيدخل عندنا لجلوكوز إلى داخل الخلية
+
+222
+00:19:45,020 --> 00:19:52,100
+زي ما واضح به ال figure هذا الـ SGL2بيعمل على دخول
+
+223
+00:19:52,100 --> 00:19:57,120
+الـ Sodium تمامًا و أيضًا بيعمل على دخول الـ
+
+224
+00:19:57,120 --> 00:20:02,420
+Glucose في نفس الوقت إلى داخل الخلايا زي الخلايا
+
+225
+00:20:02,420 --> 00:20:04,860
+الموجودة بالأمعاء على سبيل المثال هو الـ
+
+226
+00:20:04,860 --> 00:20:08,940
+Enterocytes و اللي يبجي عن طريق اللي اللي قلته
+
+227
+00:20:08,940 --> 00:20:13,720
+بيصير فيه أنه absorption للـ Glucose و دخوله إلى
+
+228
+00:20:13,720 --> 00:20:17,740
+داخل خلايا الأمعاء اللي هو الـ Enterocytes
+
+229
+00:20:23,600 --> 00:20:28,700
+الـ SGLT تدفع تحرير الجلوكوز وجالكتوز من لوم الصدر
+
+230
+00:20:28,700 --> 00:20:36,440
+الصغير والتعادل من الدم في الجلديبقى كمان الـ SGLT
+
+231
+00:20:36,440 --> 00:20:41,420
+برضه بتلعب دور في عملية الـ Reabsorption مرة أخرى
+
+232
+00:20:41,420 --> 00:20:44,900
+لجلوكوز بعد ما تصير عندنا اللي هو عملية ال
+
+233
+00:20:44,900 --> 00:20:50,840
+filtration وبيدخل لجلوكوز ضمن الفلترات كما احنا
+
+234
+00:20:50,840 --> 00:20:54,240
+عارفين في أول جزء من ال tubules اللي هو عندنا ال
+
+235
+00:20:54,240 --> 00:20:57,140
+proximal convoluted tubules بيصير في عندنا
+
+236
+00:20:57,140 --> 00:21:03,620
+Reabsorption لالكمية الأكبر أو لأغلب الـ Glucose
+
+237
+00:21:03,620 --> 00:21:08,340
+الموجود في الفلترات و اللي بيلعب دور في هذه اللي
+
+238
+00:21:08,340 --> 00:21:12,540
+هو العملية الـ Reabsorption هو برضه الـ SGL2
+
+239
+00:21:12,540 --> 00:21:17,900
+بروتينز النوع
+
+240
+00:21:17,900 --> 00:21:22,220
+التاني من ال Transporters هو اللي هو ال Glut
+
+241
+00:21:22,220 --> 00:21:26,460
+family of membrane proteins that are encoded by
+
+242
+00:21:26,460 --> 00:21:38,660
+the SLC2 genesوعنا عدد يعني من هذا ال proteins من
+
+243
+00:21:38,660 --> 00:21:44,940
+اللي هو glute 1 لغاية glute 14 وتم تسميتهم يعني
+
+244
+00:21:44,940 --> 00:21:49,920
+بناء على الوقت اكتشافهم، تمام؟ وglute 1 يعني هو
+
+245
+00:21:49,920 --> 00:21:56,900
+هذا أول protein تم اكتشافه في هذهالعائلة، وتم
+
+246
+00:21:56,900 --> 00:22:01,760
+تقسيم هذه البروتينات إلى تلت أقسام بعد هيك، زي ما
+
+247
+00:22:01,760 --> 00:22:04,000
+احنا شايفين في عندنا class one، في عندنا class
+
+248
+00:22:04,000 --> 00:22:08,400
+two، وفي عندنا اللي هو class three، هذه التقسيمة
+
+249
+00:22:08,400 --> 00:22:13,400
+تمت بناءً على الـ sequence similarities، وبناءً
+
+250
+00:22:13,400 --> 00:22:19,380
+على اللي هو التشابه بالخصائص للبروتينات المختلفة
+
+251
+00:22:22,100 --> 00:22:26,260
+البروتينات المختلفة يعني موجودة زي ما هو واضح حال
+
+252
+00:22:26,260 --> 00:22:30,680
+من خلال الـ Table فيه tissues مختلفة، يعني إن الـ
+
+253
+00:22:30,680 --> 00:22:33,660
+Glut1 على سبيل المثالاللي هو موجود بالـ
+
+254
+00:22:33,660 --> 00:22:37,800
+Erythrocyte، الـ Brain، Blood-Brain Barrier، Fetal
+
+255
+00:22:37,800 --> 00:22:41,300
+Tissues، Glut2 موجود في الـ Liver و Beta Cells of
+
+256
+00:22:41,300 --> 00:22:45,200
+the Pancreas، Glut4، Skeletal Muscle و Cardiac
+
+257
+00:22:45,200 --> 00:22:48,480
+Muscle تمام، يبقى عندنا الأنواع المختلفة من هذه
+
+258
+00:22:48,480 --> 00:22:52,860
+البروتينات موجودة في tissues مختلفة وممكن نجي أكتر
+
+259
+00:22:52,860 --> 00:23:01,270
+من نوع موجود في نفس الـ tissueوبعض هذه الأنواع من
+
+260
+00:23:01,270 --> 00:23:07,550
+الـ protein اللي هو الـ Glute بيلعب دور غير اللي
+
+261
+00:23:07,550 --> 00:23:13,530
+هو موضوع نقل لـ Glucose زي أن الـ Glute 9 اللي هو
+
+262
+00:23:13,530 --> 00:23:18,300
+Transports Ureaعنا على سبيل المثال اللي هو «Glut
+
+263
+00:23:18,300 --> 00:23:24,260
+-13» «هيدا» «ترانسبورز» «مايو» «انوسيتول» اللي هو
+
+264
+00:23:24,260 --> 00:23:29,000
+فيه يعني tissues زي الـ «براين» والـ «أليبوز»
+
+265
+00:23:29,000 --> 00:23:35,200
+tissue يبقى أغلب هذه البروتينات مسئولة عن نقل لـ
+
+266
+00:23:35,200 --> 00:23:41,000
+«جلوكوز» لكن عنا فيه زي ما شوفنا البعض منها بينقل
+
+267
+00:23:41,000 --> 00:23:42,360
+بواد أخرى
+
+268
+00:23:46,070 --> 00:23:49,510
+هؤلاء الانتجارات تم تسمح بـ Glut-1 لـ Glut-14
+
+269
+00:23:49,510 --> 00:23:55,390
+بناءً على حركة الانتجارات التي تم اكتشافها، 11 تم
+
+270
+00:23:55,390 --> 00:24:02,410
+إظهارها لإنتجار الكلوكوز، وكذلك الكثير
+
+271
+00:24:02,410 --> 00:24:07,470
+منهم ينتجون أيضًا ريكزوز مثل Galactose, Fractose,
+
+272
+00:24:07,930 --> 00:24:14,310
+Manose و Exyloseكمثال على هذه البروتينات اللي
+
+273
+00:24:14,310 --> 00:24:19,310
+بتعمل على نقل الجلوكوز لو حكينا على glut4 when
+
+274
+00:24:19,310 --> 00:24:23,150
+circulating insulin concentrations are low most of
+
+275
+00:24:23,150 --> 00:24:26,630
+the glut4 is localized in intracellular
+
+276
+00:24:26,630 --> 00:24:30,810
+compartments يبقى لما نكون عندنا مستويات الانسولين
+
+277
+00:24:30,810 --> 00:24:35,830
+قليلة منخفضة يعني بمعناه أنه عندنا ال glucose
+
+278
+00:24:35,830 --> 00:24:40,020
+concentration في الدم يعني ضمنالـ Reference
+
+279
+00:24:40,020 --> 00:24:43,860
+Interval أو ضمن يعني الـ Reference Range يبقى
+
+280
+00:24:43,860 --> 00:24:47,400
+بيكون أن الـ Glucose Transporter اللي هو مثلًا
+
+281
+00:24:47,400 --> 00:24:53,240
+مثلًا Glut4 بيكون موجود في داخل الـ Cytoplasm في
+
+282
+00:24:53,240 --> 00:24:57,420
+داخل الخلية، بيكون مش موجود على ال cell membrane
+
+283
+00:24:57,420 --> 00:25:00,960
+يبقى Localized in Intracellular compartments and
+
+284
+00:25:00,960 --> 00:25:08,310
+is inactive لكن بعد ما الإنسان بيتناول الطعامو
+
+285
+00:25:08,310 --> 00:25:12,330
+اللي هو الموجود فيه carbohydrates يبقى بيبدأ يصير
+
+286
+00:25:12,330 --> 00:25:19,410
+فينا ارتفاع في مستوى ال insulin و زي ما شفنا بال
+
+287
+00:25:19,410 --> 00:25:24,570
+figure الخاص بالميكانزم من ضمن ال mechanisms اللي
+
+288
+00:25:24,570 --> 00:25:30,910
+بيقوم فيها ال insulin هوالـ Activation لـ AKT، وهو
+
+289
+00:25:30,910 --> 00:25:37,410
+مسئول عن حدوث Translocation لجلوتفور لبلازماممبرين
+
+290
+00:25:37,410 --> 00:25:42,630
+وبالتالي دخول كميات أكبر من الجلوكوز into skeletal
+
+291
+00:25:42,630 --> 00:25:50,510
+muscle and fatالإنسيولين يدفع الجلوكوز للتواصل إلى
+
+292
+00:25:50,510 --> 00:25:54,250
+الجلد الاسكليتالي يكون مفارقًا في الـ Type 2
+
+293
+00:25:54,250 --> 00:25:58,450
+Diabetes Mellitus ولكن الميكانيزم لم يتم إصلاحه،
+
+294
+00:25:58,450 --> 00:26:02,430
+بهذا من المشكلات الموجودة في الناس اللي عندهم Type
+
+295
+00:26:02,430 --> 00:26:05,860
+2 Diabetes Mellitusإنه عندنا الـ Insulin
+
+296
+00:26:05,860 --> 00:26:09,780
+Stimulated Glucose Transport اللي هو زي ما حكينا
+
+297
+00:26:09,780 --> 00:26:12,360
+إنه الـ Translocation اللي بتسيلها للـ
+
+298
+00:26:12,360 --> 00:26:15,900
+Transporters و اللي بتسمح بدخول كميات كبيرة من الـ
+
+299
+00:26:15,900 --> 00:26:20,880
+Glucose هذه بيصير فيها مشكلة عند الناس اللي عندهم
+
+300
+00:26:20,880 --> 00:26:24,520
+type 2 diabetes mellitus وهذا اللي بيؤدي إلى طبعا
+
+301
+00:26:24,520 --> 00:26:28,880
+الـ Hyperglycemia و الارتفاع اللي هو الـ Glucose
+
+302
+00:26:28,880 --> 00:26:33,180
+الكبير اللي بيصير بعد تناول الواجبات
+
+303
+00:26:36,140 --> 00:26:40,380
+الهرمون الآخر الأساسي اللي بيلعب دور في عملية الـ
+
+304
+00:26:40,380 --> 00:26:46,460
+Regulation للجلوكوز أنه الـ Glucagon هو عبارة عن
+
+305
+00:26:46,460 --> 00:26:52,320
+29-Amino Acid Polypeptide وبيتم إفرازه من خلايا
+
+306
+00:26:52,320 --> 00:26:56,820
+تسمى الـ Fossils وهذه موجودة في الـ Islets of
+
+307
+00:26:56,820 --> 00:27:04,370
+Langerhans في البنكرياسالـ Glucagon أيضًا بيُفرز
+
+308
+00:27:04,370 --> 00:27:10,530
+أو بيتم بـ cellosynthesis in an inactive form Pro
+
+309
+00:27:10,530 --> 00:27:18,140
+-Glucagon وبعد هيك بيصير فيها أناكتفيشن لهذا
+
+310
+00:27:18,140 --> 00:27:22,640
+البروتين عن طريق الـ Pro-Hormone Convertease-II
+
+311
+00:27:22,640 --> 00:27:27,860
+اللي بيصير كليفش لجزء من الـ Pro-Glucagon وبيتحول
+
+312
+00:27:27,860 --> 00:27:33,100
+إلى Active-Glucagon Major target organ for
+
+313
+00:27:33,100 --> 00:27:37,960
+glucagon is the liverواحنا عارفين إنه الـ Glucagon
+
+314
+00:27:37,960 --> 00:27:43,600
+عبارة عن hyperglycemic agent يبقى هو بيعمل على رفع
+
+315
+00:27:43,600 --> 00:27:53,280
+مستوى لجلوجوز في الدم في حال اللي هو الصيام يبقى
+
+316
+00:27:53,280 --> 00:27:57,660
+فيه ال liver، ال glucagon بيرتبط لنوع من ال
+
+317
+00:27:57,660 --> 00:28:01,660
+receptors اللي يسمى G-protein coupled receptor
+
+318
+00:28:03,400 --> 00:28:08,720
+الذي يتم إظهاره عاليًا في الجلد والقلق وعلى أقل
+
+319
+00:28:08,720 --> 00:28:14,400
+مدى في أشياء أخرى مثل قلق أدبوه، بانكرياه وعقل
+
+320
+00:28:14,400 --> 00:28:20,420
+عقلي.الجلوكاجون تشجع نشطة الوصول للجلوكوز في الجلد
+
+321
+00:28:20,880 --> 00:28:24,840
+بـ Predominantly by Glucogenolysis بهادي العمليات
+
+322
+00:28:24,840 --> 00:28:28,820
+اللي بيشتغل من خلالها الجلوكاجون واللي بيعمل على
+
+323
+00:28:28,820 --> 00:28:32,500
+رفع مستوى الجلوكوز في الدم أن العملية الأولى
+
+324
+00:28:32,500 --> 00:28:35,660
+Glucogenolysis اللي هو عملية التكسير اللي بتصير
+
+325
+00:28:35,660 --> 00:28:42,400
+للـGlycogen اللي تم تخزينه وأيضا يبقى الانتاج هان
+
+326
+00:28:42,400 --> 00:28:48,180
+لجلوكوز من اللي هو الـGlycogen stores وأيضا برضه
+
+327
+00:28:48,180 --> 00:28:52,090
+فيه أنه Gluconeogenesisاللي هو production of
+
+328
+00:28:52,090 --> 00:28:56,470
+glucose from non-carbohydrate sources بجهة دي برضه
+
+329
+00:28:56,470 --> 00:29:03,670
+العملية بسلها activation وبرضه بنفس الوقت هان
+
+330
+00:29:03,670 --> 00:29:07,890
+عملية اللي هو التخزين للجلوكوز بسلها inhibition
+
+331
+00:29:07,890 --> 00:29:11,690
+بجهة glucogenesis بسلها inhibition لإن احنا هنا
+
+332
+00:29:11,690 --> 00:29:17,130
+بحاجة إلى رفع مستوى الجلوكوز في الدم
+
+333
+00:29:19,720 --> 00:29:23,220
+الـ Glucagon secretion is regulated primarily by
+
+334
+00:29:23,220 --> 00:29:27,420
+plasma glucose concentrations، بيحسب مستوى
+
+335
+00:29:27,420 --> 00:29:31,700
+الجلوكوز في الدم، إذا انخفض مستوى الجلوكوز في الدم
+
+336
+00:29:31,700 --> 00:29:37,460
+عن 70، يبجيها أن بيصير في عندنا stimulation للـ
+
+337
+00:29:37,460 --> 00:29:41,160
+alpha cells في البنكرياز عشان تعمل release
+
+338
+00:29:41,160 --> 00:29:42,580
+للجلوكاجون
+
+339
+00:29:44,380 --> 00:29:47,700
+with low and high plasma glucose being stimulatory
+
+340
+00:29:47,700 --> 00:29:52,220
+and inhibitory respectively ولمّا يكون عندنا ال
+
+341
+00:29:52,220 --> 00:29:56,360
+plasma glucose منخفضة يبقى ده بيعمل stimulation ل
+
+342
+00:29:56,360 --> 00:30:01,480
+ال release of glucagon لكن لو كان عندنا ال plasma
+
+343
+00:30:01,480 --> 00:30:06,190
+glucose مرتفعةيبقى معناته حيصير فيه إنه في هذه
+
+344
+00:30:06,190 --> 00:30:10,250
+الحالة Release لـ Insulin و اللي هيعمل Inhibition
+
+345
+00:30:10,250 --> 00:30:15,030
+على الـ Alpha Cells وبالتالي هيقلل من إفراز
+
+346
+00:30:15,030 --> 00:30:19,590
+لـGlucagon Long-standing diabetes mellitus impairs
+
+347
+00:30:19,590 --> 00:30:24,110
+the glucagon response to hypoglycemia وهذه مشكلة
+
+348
+00:30:24,110 --> 00:30:30,790
+من المشكلات اللي ممكن تكون موجودة عند الناس اللي
+
+349
+00:30:30,790 --> 00:30:37,630
+عندهم diabetesواللي بتؤدي إلى حدوث Hypoiglycemia
+
+350
+00:30:37,630 --> 00:30:42,810
+يبقى الـ Longstanding Diabetes Mellitus بيأثر على
+
+351
+00:30:42,810 --> 00:30:49,010
+الـ Glucagon response to Hypoiglycemiaيبقى المفروض
+
+352
+00:30:49,010 --> 00:30:52,310
+إحنا زي ما قلنا إنه لو صار فينا انخفاض لجلوكوز عن
+
+353
+00:30:52,310 --> 00:30:56,210
+70 ميلي جرام per ديسليتر يبقى مباشرة المفروض يصير
+
+354
+00:30:56,210 --> 00:31:01,150
+في release للـGlucagon لكن المشكلة إنه الإصابة
+
+355
+00:31:01,150 --> 00:31:05,430
+بفترة طويلة بالـDiabetes Mellitus هذا هيأثر على
+
+356
+00:31:05,430 --> 00:31:10,910
+هذه العملية وبالتالي هذا هيزيد من الـHypoglycemic
+
+357
+00:31:10,910 --> 00:31:12,050
+episodes
+
+358
+00:31:15,550 --> 00:31:19,530
+بما يتعلق بالناس اللي عندهم type 1 diabetes
+
+359
+00:31:19,530 --> 00:31:27,410
+mellitus ومن خلال الأبحاث المختلفة لجوا إنه اللي
+
+360
+00:31:27,410 --> 00:31:29,770
+هو الـ response أو الـ glucagonal response
+
+361
+00:31:29,770 --> 00:31:37,130
+لهيبوإجليسيميا ممكن تحدث في فترة قصيرة لو الناس
+
+362
+00:31:37,130 --> 00:31:40,880
+اللي عندهم type 1 diabetes mellitusطبعا يبقى ممكن
+
+363
+00:31:40,880 --> 00:31:46,300
+هذه تحدث في فترة قصيرة يعني ممكن تحدث في فترة اللي
+
+364
+00:31:46,300 --> 00:31:52,380
+هي لا تتجاوز ممكن الشهر أو الشهرينممكن يصير في عنا
+
+365
+00:31:52,380 --> 00:31:58,340
+ليه مشكلة الـGlucagon أو اللي هو انخفاض في
+
+366
+00:31:58,340 --> 00:32:02,520
+الـGlucagon response to hypoglycemia بالتالي هذا
+
+367
+00:32:02,520 --> 00:32:09,680
+قلنا إنه بيعمل ممكن مشكلة وممكن يزيد من اللي هو
+
+368
+00:32:09,680 --> 00:32:14,360
+حدوث الـhypoglycemia episodes and هدول المرضى
+
+369
+00:32:14,360 --> 00:32:19,340
+Stress exercise and amino acids induce glucagon
+
+370
+00:32:19,340 --> 00:32:24,040
+releaseالـ IB هذه كلها أكيد بتحتاج إلى ارتفاع في
+
+371
+00:32:24,040 --> 00:32:29,840
+مستوى الجلوكوزة وبالتالي كلها بتعمل على زيادة الـ
+
+372
+00:32:29,840 --> 00:32:33,940
+release of glucagon طيب ال stress ال exercise دم
+
+373
+00:32:33,940 --> 00:32:37,300
+متفقين أن هذه بتحتاج إلى اللي هو الجلوكوزة
+
+374
+00:32:37,300 --> 00:32:40,140
+وبالتالي بدنا glucagon release طب ال amino acids
+
+375
+00:32:40,140 --> 00:32:45,900
+يعني المفروض ال amino acids أمتى بتصير موجودة في
+
+376
+00:32:45,900 --> 00:32:48,240
+الدم أو تزيد ال concentration في الدم بعد تناول
+
+377
+00:32:48,240 --> 00:32:52,980
+وجبةطب ليش بقى أنتنا هو الوشبة بده يرتفع عندنا
+
+378
+00:32:52,980 --> 00:32:56,120
+الـGlucagon؟ مع أنه المفروض أنه يصير في عندنا
+
+379
+00:32:56,120 --> 00:33:01,400
+انخفاض، واللي يرتفع هو الـInsulin، وفعليًا
+
+380
+00:33:01,400 --> 00:33:07,740
+الـInsulin بيرتفع، تمام؟ لكن برضه الـAmino Acids
+
+381
+00:33:07,740 --> 00:33:15,570
+بتعمل على رفع الـGlucagonوهذه العملية يعني فيها
+
+382
+00:33:15,570 --> 00:33:21,290
+توازن ومرتبطة بالـ glucose concentration ومرتبطة
+
+383
+00:33:21,290 --> 00:33:27,570
+بالـ insulin أيضًا لأنه احنا عندنا الجسم الآن بعد
+
+384
+00:33:27,570 --> 00:33:31,870
+تناول وجبةصار فينا ارتفاع في الـ Amino Acids صار
+
+385
+00:33:31,870 --> 00:33:36,350
+فينا ارتفاع في الجلوكوز صار فينا إفراز للإنسلين
+
+386
+00:33:36,350 --> 00:33:40,210
+والإنسلين بدأ يخفض من مستويات الجلوكوز بالدم يبقى
+
+387
+00:33:40,210 --> 00:33:44,550
+أحنا ما نقدرش أنه نوقف عمل الـ Alpha cells
+
+388
+00:33:44,550 --> 00:33:48,630
+ومايكونش فينا Glucagon موجود في الدم لأن هذا ممكن
+
+389
+00:33:48,630 --> 00:33:52,750
+يؤدي إلى حدوث Hypo-Glycemia يعني هذه العملية بيصير
+
+390
+00:33:52,750 --> 00:33:57,110
+فيها توازن وبيبدأ يصير فينا يعني Release لكميات
+
+391
+00:33:57,520 --> 00:34:02,580
+بسيطة من الـGlucagon عشان يمنع من حدوث
+
+392
+00:34:02,580 --> 00:34:09,040
+الـHypoglycemia.إنسولين يهيبط إطلاق الـGlucagon من
+
+393
+00:34:09,040 --> 00:34:13,360
+البنكريات ويقلل إطلاق الـGlucagon في إظهار الجنة
+
+394
+00:34:13,360 --> 00:34:17,920
+بمجرد إضافة بيو-سينتيزاتها زي ما حكينا قبل شوية
+
+395
+00:34:17,920 --> 00:34:22,000
+قولنا إن الإنسولين بيعمل Inhibition على الـAlpha
+
+396
+00:34:22,000 --> 00:34:29,090
+cellsوهي بالتالي بيمنع الـ glucagon release وهذا
+
+397
+00:34:29,090 --> 00:34:33,490
+بيكون عن طريق اللي هو خفض الـ glucagon gene
+
+398
+00:34:33,490 --> 00:34:41,110
+expression في أخلق الـ alpha cells increase
+
+399
+00:34:41,110 --> 00:34:44,350
+in glucagon concentrations secondary to insulin
+
+400
+00:34:44,350 --> 00:34:47,870
+deficiency are believed to contribute to the
+
+401
+00:34:47,870 --> 00:34:53,090
+hyperglycemia and ketosis of diabetesأحنا قلنا إنه
+
+402
+00:34:53,090 --> 00:34:57,490
+الـ Insulin بيعمل Inhibition على الـ Alpha Cells
+
+403
+00:34:57,490 --> 00:35:03,390
+وبيمنع من إفراز الجلوكاجون الآن في حالات اللي هو
+
+404
+00:35:03,390 --> 00:35:06,890
+الـ Type I Diabetes Mellitus زي ما قلنا إنه في الـ
+
+405
+00:35:06,890 --> 00:35:11,310
+Type I فينا Absolute Deficiency of Insulin يبقى
+
+406
+00:35:11,310 --> 00:35:14,390
+مازال الـ Insulin مش موجود يبقى الـ Inhibitor
+
+407
+00:35:14,390 --> 00:35:18,490
+Effect اللي بيقوم فيها الـ Insulin على الـ Alpha
+
+408
+00:35:18,490 --> 00:35:23,650
+Cells مش هتكون موجودةبيادة هيؤدي إلى زيادة في
+
+409
+00:35:23,650 --> 00:35:28,530
+الـglucagon concentration وما زال صار في عنا زيادة
+
+410
+00:35:28,530 --> 00:35:31,170
+في الـglucagon concentration هصير في عنا
+
+411
+00:35:31,170 --> 00:35:35,410
+stimulation للـgluconeogenesis وهصير في عنا الو
+
+412
+00:35:35,410 --> 00:35:39,450
+اكسيداشن لـالـ Fatty Acids وبالتالي حيصير فيها إنه
+
+413
+00:35:39,450 --> 00:35:45,770
+إنتاج لكميات كبيرة من الـ Ketone Bodies وهذا اللي
+
+414
+00:35:45,770 --> 00:35:50,930
+ممكن يؤدي إلى الـ Ketosis أو Ketoacidosis عند
+
+415
+00:35:50,930 --> 00:35:55,330
+الناس اللي عندهم type 1 diabetes malatus بعدم وجود
+
+416
+00:35:55,330 --> 00:36:00,790
+الإنسولين مع ارتفاع الجلوكاجون هذا اللي ممكن يكون
+
+417
+00:36:00,790 --> 00:36:03,570
+سبب حدوث الـ Ketosis
+
+418
+00:36:06,070 --> 00:36:11,360
+غير الـ Alpha Cells، فينا أيضًا خلايا أخرىبتفرز
+
+419
+00:36:11,360 --> 00:36:16,680
+الـ Pro-Glucagon ومن هذه الخلايا عندنا الـ
+
+420
+00:36:16,680 --> 00:36:20,000
+Enteroendocrine الـ cells الموجودة في الأمعاء
+
+421
+00:36:20,000 --> 00:36:27,120
+وعندنا أيضًا الـ neurons اللي هي هذه الـ neurons
+
+422
+00:36:27,120 --> 00:36:30,360
+هي اللي بتعمل على نقل يعني نوع من الـ neurons اللي
+
+423
+00:36:30,360 --> 00:36:35,580
+بيعمل على نقل الـ signals من الـ digestive tract
+
+424
+00:36:35,580 --> 00:36:40,560
+لبراين أو من براين لـالـ Digestive Attract بيهدى
+
+425
+00:36:40,560 --> 00:36:45,000
+الخلايا بتعمل أيضًا على إفراز أو إنتاج لـ Pro
+
+426
+00:36:45,000 --> 00:36:51,280
+-Glucagon في الـ Intestinal L-cells Pro-Glucagon
+
+427
+00:36:51,280 --> 00:36:55,940
+بيصلوا برضه إكليفج عن طريق Enzymes لأن Pro-Hormone
+
+428
+00:36:55,940 --> 00:37:01,870
+Converters 1A3وبيحول هذا الانزيم بيحول الـ Pro
+
+429
+00:37:01,870 --> 00:37:06,990
+-Glucagon إلى Glucagon-like peptide اللي يعني GLP
+
+430
+00:37:06,990 --> 00:37:15,430
+-1 و GLP-2 و أيضًا hormones أخرى هذا النوع من ال
+
+431
+00:37:15,430 --> 00:37:21,830
+hormones و اللي بيتم إنتاجه بسبب التناول الطعام
+
+432
+00:37:22,770 --> 00:37:26,070
+بيعمل stimulation للـ beta cells الموجودة
+
+433
+00:37:26,070 --> 00:37:32,350
+بالبنكرياس لإفراز الإنسولين يبقى potentiate
+
+434
+00:37:32,350 --> 00:37:36,750
+glucose-induced insulin secretion أيضًا وبيعمل
+
+435
+00:37:36,750 --> 00:37:42,130
+inhibition لـglucagon secretionبالـ GLB1 وعنا
+
+436
+00:37:42,130 --> 00:37:47,070
+أيضًا هرمون آخر Gestric Inhibitory Polypeptide أو
+
+437
+00:37:47,070 --> 00:37:49,510
+بروتين آخر اللي هو الـ Gestric Inhibitory
+
+438
+00:37:49,510 --> 00:37:55,710
+Polypeptide برضه هدول اللي هو الـ two hormones
+
+439
+00:37:55,710 --> 00:38:00,830
+مسئولين for up to 70% of postprandial insulin
+
+440
+00:38:00,830 --> 00:38:01,810
+secretion
+
+441
+00:38:04,000 --> 00:38:08,740
+يبقى مع تناول الطعام، في عندنا هرمونات اللي بتتم
+
+442
+00:38:08,740 --> 00:38:13,460
+إنتاجها، وهذه الهرمونات بتعمل اللي هو stimulation
+
+443
+00:38:13,460 --> 00:38:20,160
+لزيادة الـ Insulin وبالتالي عدم ارتفاع الـ glucose
+
+444
+00:38:20,160 --> 00:38:23,660
+في الدم إلى مستويات مرتفعة
+
+445
+00:38:26,930 --> 00:38:34,350
+الـ GLP-1 موجودة في تشيز مختلفة ومش فقط في الـ
+
+446
+00:38:34,350 --> 00:38:40,550
+Pancreas يبقى widely expressed وبتلعب دور مهم في
+
+447
+00:38:40,550 --> 00:38:45,210
+عملية الـ regulation للجلوكوز concentration من
+
+448
+00:38:45,210 --> 00:38:51,670
+خلال ميكانيزمز مختلفة ومن ضمن هذه الميكانيزمز إن
+
+449
+00:38:51,670 --> 00:38:55,930
+الـ inhibition of glucose production and food
+
+450
+00:38:55,930 --> 00:39:02,500
+intakeتمام، يبقى من ضمن اللي هو الـ .. الـ
+
+451
+00:39:02,500 --> 00:39:04,560
+mechanisms طبعا زي ما حكيها أنا السابق لإنه بزيد
+
+452
+00:39:04,560 --> 00:39:10,780
+الـ insulin secretion لكن برضه بيمنع من ال glucose
+
+453
+00:39:10,780 --> 00:39:15,580
+production وبيمنع برضه أو بيقلل ممكن من ال uptake
+
+454
+00:39:15,580 --> 00:39:22,080
+وبالتالي ال food intake عشان هيك ال GLP-1
+
+455
+00:39:22,080 --> 00:39:26,020
+analoguesare generating interest in the treatment
+
+456
+00:39:26,020 --> 00:39:31,800
+of type 2 diabetes في عندنا أدوية وهذه عبارة عن
+
+457
+00:39:31,800 --> 00:39:37,800
+GLB1 Analog تمام بيغير أنه ممكن تعمل release
+
+458
+00:39:37,800 --> 00:39:41,920
+للإنسلين لكن برضه بتقلل من إنتاج الوالي glucose
+
+459
+00:39:41,920 --> 00:39:50,240
+وأيضا بتقلل من ال uptakeوفي أربع أدوية يعني تم
+
+460
+00:39:50,240 --> 00:39:55,240
+إنتاجها وحصلت على الـ Approval من الـ Food and
+
+461
+00:39:55,240 --> 00:40:00,580
+Drug Administration لإستعمالها مع مرضى Type 2
+
+462
+00:40:00,580 --> 00:40:02,440
+Diabetes Mellitus
+
diff --git a/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/wr_r91FrC-Q.srt b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/wr_r91FrC-Q.srt
new file mode 100644
index 0000000000000000000000000000000000000000..2249522d95bcc69ccb5a93b7715b42b2dabd4fc0
--- /dev/null
+++ b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/wr_r91FrC-Q.srt
@@ -0,0 +1,2023 @@
+1
+00:00:02,700 --> 00:00:06,780
+طيب بما يتعلق بـ management لـ diabetes
+
+2
+00:00:06,780 --> 00:00:13,900
+patients، في عندنا الـ acute management، يعني للي
+
+3
+00:00:13,900 --> 00:00:19,940
+اللي هو الـ acute cases ممكن
+
+4
+00:00:19,940 --> 00:00:25,320
+وفي عندنا اللي هو في الـ chronic بالنسبة لـ
+
+5
+00:00:25,320 --> 00:00:33,040
+acute، في عندنا من الـ conditions اللي ممكن
+
+6
+00:00:33,040 --> 00:00:37,220
+يصاب فيها الناس المصابين بالسكري، فيه الـ
+
+7
+00:00:37,220 --> 00:00:41,740
+ketoacidosis، فيه الـ hyperosmolar non-
+
+8
+00:00:41,740 --> 00:00:46,540
+ketotic coma، و hypoglycemia
+
+9
+00:00:48,230 --> 00:00:52,410
+طبعًا حالات مختلفة هذه، أكيد المختبر بيلعب دور مهم
+
+10
+00:00:52,410 --> 00:00:59,250
+في الـ diagnosis لهذه الحالات المختلفة، وأكيد برضه
+
+11
+00:00:59,250 --> 00:01:04,830
+له دور مهم في المتابعة، ومتابعة الأدوية اللي هيعطاها
+
+12
+00:01:04,830 --> 00:01:13,010
+للمرضى في هذه الحالات الثلاثة، من الفحوصات المختلفة
+
+13
+00:01:13,010 --> 00:01:20,220
+اللي بتتم، سواء اللي طبعًا بداية الـ diagnosis، وتحديد
+
+14
+00:01:20,220 --> 00:01:27,420
+العلاج اللازم، ولغاية طبعًا ما يصل الـ glucose
+
+15
+00:01:27,420 --> 00:01:31,940
+concentration إلى الـ range الطبيعية
+
+16
+00:01:33,330 --> 00:01:37,670
+عندنا الـ glucose in blood and urine، وهذه الفحوصات
+
+17
+00:01:37,670 --> 00:01:41,050
+اللي بتتم فيها أن الـ ketones برضه in blood and
+
+18
+00:01:41,050 --> 00:01:45,650
+urine، أكيد الـ acid-base status، الـ pH، والـ
+
+19
+00:01:45,650 --> 00:01:51,910
+bicarbonate level، الـ lactate، وأيضًا فحوصات اللي لها
+
+20
+00:01:51,910 --> 00:01:54,730
+علاقة ممكن بـ dehydration
+
+21
+00:01:56,660 --> 00:02:00,780
+أو المتعلقة بـ Dialysis السابقة، بالمثال
+
+22
+00:02:00,780 --> 00:02:07,360
+في أن البوتاسيوم والصوديوم، والفوسفات، وأيضًا الـ
+
+23
+00:02:07,360 --> 00:02:13,840
+osmolality، من هذه الفحوصات، في أن الـ ketone bodies
+
+24
+00:02:13,840 --> 00:02:18,600
+development of ketosis requires changes in both
+
+25
+00:02:18,600 --> 00:02:26,520
+adipose tissue and the liver. Primary substrate for
+
+26
+00:02:26,520 --> 00:02:29,300
+ketone body formation are free fatty acids from
+
+27
+00:02:29,300 --> 00:02:39,480
+adipose stores. طبعًا الـ ketone bodies بتنتج، بتم
+
+28
+00:02:39,480 --> 00:02:49,460
+إنتاجها طبعًا من خلال الـ lipolysis، طبعًا في نقص في
+
+29
+00:02:49,460 --> 00:02:56,850
+الـ insulin، لأن الـ ketosis يعني عادة بتظهر عند اللي
+
+30
+00:02:56,850 --> 00:03:00,010
+هو المرضى بالنوع الأول، الـ Type 1 diabetes mellitus
+
+31
+00:03:00,630 --> 00:03:05,450
+ونادرًا ما نشوف ناس عندهم الـ Type 2 diabetes
+
+32
+00:03:05,450 --> 00:03:12,030
+mellitus وعندهم ketosis، ليش؟ لأنه الناس اللي هو
+
+33
+00:03:12,030 --> 00:03:14,410
+مرضى الـ Type 2 diabetes mellitus في عندهم
+
+34
+00:03:14,410 --> 00:03:18,350
+insulin، الـ insulin موجود، وبالتالي الـ insulin ممكن
+
+35
+00:03:18,350 --> 00:03:23,070
+يعمل inhibition على الـ alpha cells، ويقلل من
+
+36
+00:03:23,070 --> 00:03:28,480
+الجلوكاجون، لكن مرضى النوع الأول، زي ما حكينا سابقًا،
+
+37
+00:03:28,480 --> 00:03:33,380
+أن فيه absolute deficiency of insulin، وبالتالي
+
+38
+00:03:33,380 --> 00:03:37,980
+الـ inhibitory effect للانسولين على الـ alpha cells
+
+39
+00:03:37,980 --> 00:03:41,960
+مش موجودة، وبالتالي الـ alpha cells هتنتج glucagon
+
+40
+00:03:41,960 --> 00:03:48,980
+وهيكون فيه gluconeogenesis، وبالتالي سيكون هناك
+
+41
+00:03:48,980 --> 00:03:55,100
+breakdown للدهون، وإنتاج لكميات كبيرة من الـ ketone
+
+42
+00:03:55,100 --> 00:03:56,280
+bodies
+
+43
+00:03:59,780 --> 00:04:04,780
+الدهون طبعًا يعني بيصير فيها تخزين في الكبد على شكل
+
+44
+00:04:04,780 --> 00:04:09,260
+الـ triglycerides، وطبعًا الـ triglycerides هذه ممكن
+
+45
+00:04:09,260 --> 00:04:12,620
+تُحمل على الـ VLDL، اللي هو الـ Very Low Density
+
+46
+00:04:12,620 --> 00:04:19,380
+Lipoprotein، ويصير لها release، لتوزيعها على
+
+47
+00:04:19,380 --> 00:04:20,940
+الخلايا
+
+48
+00:04:24,370 --> 00:04:26,590
+بالنسبة لـ، In contrast to other tissues، the
+
+49
+00:04:26,590 --> 00:04:30,790
+brain cannot use free fatty acids for energy
+
+50
+00:04:30,790 --> 00:04:35,630
+وبالتالي، في عندنا اللي هو الـ ketone bodies اللي
+
+51
+00:04:35,630 --> 00:04:39,810
+بتتكون، واللي ممكن يستخدمها الدماغ، When glucose is
+
+52
+00:04:39,810 --> 00:04:42,030
+unavailable، ketone bodies supply the vast
+
+53
+00:04:42,030 --> 00:04:48,450
+majority of the brain's energy. وإذا كان صار فيه صوم
+
+54
+00:04:48,450 --> 00:04:53,030
+اللي هو لمدة ثلاثة أيام، ketone bodies provide 30
+
+55
+00:04:53,030 --> 00:04:56,250
+percent to 40 percent of the body's energy
+
+56
+00:04:56,250 --> 00:04:57,410
+requirement
+
+57
+00:04:59,780 --> 00:05:04,780
+يبقى أن الـ ketosis، والارتفاع في الـ ketone bodies
+
+58
+00:05:04,780 --> 00:05:09,820
+يعني بيصير في الـ uncontrolled diabetes، اللي بنحكي
+
+59
+00:05:09,820 --> 00:05:15,060
+عليه، يعني بشكل أخص على اللي هو الـ Type 1، زي ما
+
+60
+00:05:15,060 --> 00:05:18,260
+قلنا، هذا كان في عندنا low insulin concentration
+
+61
+00:05:18,260 --> 00:05:24,540
+هذا هيزيد من الـ lipolysis، وبالتالي هيزيد من اللي
+
+62
+00:05:24,540 --> 00:05:27,980
+هو الـ plasma free fatty acids، واللي هو تكوين الـ
+
+63
+00:05:27,980 --> 00:05:34,870
+ketone bodies. Higher Glucagon to Insulin Ratio، طب
+
+64
+00:05:34,870 --> 00:05:37,910
+عامل آخر، نقول اللي هو أن انخفاض في الانسولين بيخلي
+
+65
+00:05:37,910 --> 00:05:39,990
+الـ inhibitory effect على الـ alpha cells، وبالتالي
+
+66
+00:05:39,990 --> 00:05:43,410
+بيصير فيه أن الـ glucagon concentrations أعلى من
+
+67
+00:05:43,410 --> 00:05:46,850
+الـ glucagon، وبالتالي higher glucagon to insulin
+
+68
+00:05:46,850 --> 00:05:50,290
+ratio، هذا اللي هو enhances the fatty acid
+
+69
+00:05:50,290 --> 00:05:56,470
+oxidation in the liver. عندنا أيضًا الزيادة في الهرمونات
+
+70
+00:05:56,470 --> 00:05:58,890
+الأخرى، اللي هو الـ counterregulatory hormones، أو
+
+71
+00:05:58,890 --> 00:06:02,190
+اللي هو الـ hyperglycemic hormones، اللي كلها
+
+72
+00:06:02,190 --> 00:06:07,470
+بتزيد من الـ concentration لـ glucose،
+
+73
+00:06:07,470 --> 00:06:12,970
+وممكن يعني تساعد فيه، أو يعني تعمل اللي هو
+
+74
+00:06:12,970 --> 00:06:19,690
+stimulation لـ lipolysis برضه، وبالتالي لتكوين الـ
+
+75
+00:06:19,690 --> 00:06:22,370
+ketone bodies، أو الـ ketogenesis
+
+76
+00:06:25,020 --> 00:06:27,820
+من الـ ketone bodies، طبعًا في أن الـ acetoacetate
+
+77
+00:06:28,970 --> 00:06:31,610
+المجموعة الصغيرة تتكون من spontaneous
+
+78
+00:06:31,610 --> 00:06:37,450
+decarboxylation، وبتكون عندنا أسيتون، ولكن أكثر منها
+
+79
+00:06:37,450 --> 00:06:41,450
+تتحول إلى الـ β-hydroxybutyrate، وهذول اللي هو
+
+80
+00:06:41,450 --> 00:06:49,250
+الثلاثة ketone bodies اللي بتكون موجودة في الدم
+
+81
+00:06:49,250 --> 00:06:55,550
+والأسيتون ممكن يطلع مع النفس، اللي هو خلال الـ
+
+82
+00:06:55,550 --> 00:06:59,560
+exhalation، زي ما هو واضح في الـ figure هنا، وإن الـ
+
+83
+00:06:59,560 --> 00:07:03,640
+acetoacetate جزء منه بيتحول إلى acetone، اللي هو عن
+
+84
+00:07:03,640 --> 00:07:07,440
+طريق اللي هو decarboxylation، وإن اللي هو الجزء
+
+85
+00:07:07,440 --> 00:07:13,040
+الأكبر بيتحول إلى β-hydroxybutyrate
+
+86
+00:07:15,670 --> 00:07:19,510
+الزيادة في تكوين الـ ketone bodies، هتؤدي إلى ارتفاع
+
+87
+00:07:19,510 --> 00:07:22,110
+الـ concentration لـ ketone bodies في الدم
+
+88
+00:07:22,110 --> 00:07:28,830
+وبالتالي هيصير فينا كيتونيميا، وأيضًا الارتفاع هذا
+
+89
+00:07:28,830 --> 00:07:32,010
+في الدم، هيتؤدي إلى زيادة الـ excretion لـ ketone
+
+90
+00:07:32,010 --> 00:07:36,270
+bodies في الـ urine، وبالتالي هيكون فينا كيتونوريا
+
+91
+00:07:38,100 --> 00:07:41,320
+ممكن أيضًا عندنا الـ ketone bodies، يعني إيه ممكن
+
+92
+00:07:41,320 --> 00:07:48,540
+تتكون في حالات اللي هو النقص في الـ
+
+93
+00:07:48,540 --> 00:07:51,800
+carbohydrates، زي اللي هو الـ starvation، أو
+
+94
+00:07:51,800 --> 00:07:56,820
+frequent vomiting، أو decreased use of
+
+95
+00:07:56,820 --> 00:07:57,820
+carbohydrates
+
+96
+00:08:00,160 --> 00:08:04,520
+زي في حالات اللي هو الـ diabetes mellitus، أو في
+
+97
+00:08:04,520 --> 00:08:10,180
+حالات اللي هو الـ glycogen storage disease type one،
+
+98
+00:08:10,180 --> 00:08:17,880
+اللي هو von Gierke's disease. عندنا برضه الـ
+
+99
+00:08:17,880 --> 00:08:21,440
+اللي هو الـ diet الـ الموضة اللي هو الآن،
+
+100
+00:08:21,440 --> 00:08:27,980
+اللي هو الـ keto، تمام؟ هذا برضه بيزيد من الـ ketone
+
+101
+00:08:27,980 --> 00:08:30,980
+bodies، اللي هو الـ popular high-fat, low-
+
+102
+00:08:30,980 --> 00:08:33,480
+carbohydrate diet، بيبقى فيه عندنا low
+
+103
+00:08:33,480 --> 00:08:38,060
+carbohydrate، هنا اللي هو برضه ketogenic، وبيؤدي
+
+104
+00:08:38,060 --> 00:08:42,360
+إلى زيادة في الـ ketone bodies في الدم
+
+105
+00:08:45,300 --> 00:08:50,640
+أكثر حالات الـ ketoacidosis بنلاقيها عند اللي هو الـ
+
+106
+00:08:50,640 --> 00:08:53,220
+diabetes mellitus، زي ما قلنا، اللي هو بشكل خاص عند
+
+107
+00:08:53,220 --> 00:08:56,780
+اللي هو الـ Type 1 diabetes mellitus، وأيضًا عند
+
+108
+00:08:56,780 --> 00:09:01,780
+الناس اللي بيتناولوا يعني كحول
+
+109
+00:09:01,780 --> 00:09:07,740
+بكميات كبيرة، وهذا اللي طبعًا سبب حدوث
+
+110
+00:09:07,740 --> 00:09:13,580
+الـ ketoacidosis عند الناس اللي بيتناولوا كحول، لأنه
+
+111
+00:09:13,580 --> 00:09:18,570
+بيصير فيه impairment لـ conversion of
+
+112
+00:09:18,570 --> 00:09:22,950
+lactate to pyruvate، وهذا بيزيد من الـ hypothesis،
+
+113
+00:09:22,950 --> 00:09:29,470
+وبالتالي بيزيد من تكوين الـ ketone bodies
+
+114
+00:09:32,160 --> 00:09:36,760
+حسب توصيات الـ American Diabetes Association، أنه
+
+115
+00:09:36,760 --> 00:09:43,220
+لازم يكون فيه متابعة لمرضى diabetes
+
+116
+00:09:43,220 --> 00:09:44,900
+وخاصة اللي هو، زي ما قلنا، الـ Type 1 diabetes
+
+117
+00:09:44,900 --> 00:09:48,820
+mellitus، pregnancy with a pre-existing diabetes،
+
+118
+00:09:48,820 --> 00:09:52,740
+والنساء اللي عندهم gestational diabetes mellitus،
+
+119
+00:09:52,740 --> 00:09:57,500
+لابد أن يكون فيه متابعة للـ ketone bodies في الـ
+
+120
+00:09:57,500 --> 00:10:01,570
+urine. الشباب اللي عندهم Type 1 diabetes mellitus،
+
+121
+00:10:01,570 --> 00:10:04,290
+يجب أن يقوموا بفحوصات للكيتونات، في حالة المرض،
+
+122
+00:10:04,290 --> 00:10:08,130
+يبقى لأنه، زي ما احنا عارفين، في الـ acute illness،
+
+123
+00:10:08,130 --> 00:10:17,610
+بيزيد عندنا ممكن بعض الهرمونات، اللي بترفع، أو اللي
+
+124
+00:10:17,610 --> 00:10:22,590
+هي تعتبر hyperglycemic hormones، وبالتالي
+
+125
+00:10:22,590 --> 00:10:27,130
+ممكن تزيد من تكوين الـ ketone bodies. يبقى الـ
+
+126
+00:10:27,130 --> 00:10:30,400
+patients with Type 1 diabetes mellitus، لازم برضه
+
+127
+00:10:30,400 --> 00:10:33,840
+يتم فحصهم للـ ketones خلال الـ acute illness، أو
+
+128
+00:10:33,840 --> 00:10:37,260
+stress، أو with a consistent increase in blood
+
+129
+00:10:37,260 --> 00:10:39,740
+glucose، إذا زاد مستوى الـ glucose عن 300
+
+130
+00:10:39,740 --> 00:10:45,160
+milligram per deciliter، وبرضه خلال اللي هو الحمل،
+
+131
+00:10:46,190 --> 00:10:51,850
+أو when symptoms of ketoacidosis are present، ومن
+
+132
+00:10:51,850 --> 00:10:54,670
+الـ symptoms اللي هي الـ ketoacidosis، اللي هو فيه
+
+133
+00:10:54,670 --> 00:10:59,010
+عندنا frequent urination، extreme thirst، طبعًا high
+
+134
+00:10:59,010 --> 00:11:04,470
+blood sugar، واللي هو برضه طبعًا ارتفاع في
+
+135
+00:11:04,470 --> 00:11:11,940
+الـ ketones في الـ urine. قياس الـ ketones سواء في الـ
+
+136
+00:11:11,940 --> 00:11:15,680
+urine أو blood، widely performed in patients with
+
+137
+00:11:15,680 --> 00:11:21,300
+diabetes، سواء للـ diagnosis وأيضًا للـ monitoring
+
+138
+00:11:21,300 --> 00:11:27,400
+زي ما حكينا الآن، of diabetic ketoacidosis
+
+139
+00:11:30,120 --> 00:11:32,440
+بالنسبة للجزئية الثانية، اللي هي الـ management
+
+140
+00:11:32,440 --> 00:11:39,520
+للحالات chronic، وطبعًا من خلال الدراسات المختلفة
+
+141
+00:11:39,520 --> 00:11:47,700
+اللي تمت، واللي ربطت بين مستويات الجلوكوز في الدم
+
+142
+00:11:47,700 --> 00:11:51,520
+و الـ development of long-term complications of
+
+143
+00:11:51,520 --> 00:11:58,060
+diabetes، وعشان هيك لازم يكون فيه متابعة لمرضى
+
+144
+00:11:58,060 --> 00:12:05,220
+السكري باستمرار، والمحافظة على levels من الـ glucose
+
+145
+00:12:05,220 --> 00:12:10,640
+اللي تكون يعني إلى حد ما قريبة، ممكن من الـ
+
+146
+00:12:10,640 --> 00:12:13,640
+reference range، أو ممكن تكون أعلى شوية، لكن ما يكونش
+
+147
+00:12:13,640 --> 00:12:18,990
+فيه عندنا ارتفاع بشكل كبير في الـ glucose، لأنه
+
+148
+00:12:18,990 --> 00:12:24,090
+الارتفاع في الـ glucose مرتبط بالـ complications
+
+149
+00:12:24,090 --> 00:12:30,780
+المختلفة اللي ممكن تصير لمرضى السكري. ما يتعلق طبعًا
+
+150
+00:12:30,780 --> 00:12:36,400
+بيه الـ management لـ patients، فيه على مستوى اللي
+
+151
+00:12:36,400 --> 00:12:39,820
+هو القصير، وعلى المستوى البعيد، طبعًا إن الـ
+
+152
+00:12:39,820 --> 00:12:45,040
+short-term، ممكن من خلال مستويات الـ glucose، وفي
+
+153
+00:12:45,040 --> 00:12:49,840
+عندنا الـ long-term monitoring، من خلال قياس الـ
+
+154
+00:12:49,840 --> 00:12:51,880
+glycated proteins
+
+155
+00:12:53,870 --> 00:12:58,850
+الـ detection and monitoring of complications، طبعًا
+
+156
+00:12:58,850 --> 00:13:04,350
+بالمختبر احنا ممكن نشوف الـ complications اللي
+
+157
+00:13:04,350 --> 00:13:09,610
+متعلقة بـ kidney disease، وبالـ nephropathy، وهذا
+
+158
+00:13:09,610 --> 00:13:12,950
+ممكن بيكون من خلال الـ kidney function tests، زي
+
+159
+00:13:12,950 --> 00:13:19,030
+عندنا الـ creatinine، وبرضه من خلال الـ testing
+
+160
+00:13:19,030 --> 00:13:21,010
+urine for albuminuria
+
+161
+00:13:23,400 --> 00:13:30,480
+برضه في حال أن المريض يعني خضع لبعض العلاجات، زي
+
+162
+00:13:30,480 --> 00:13:34,200
+اللي هو الـ islet cell، أو الـ pancreas
+
+163
+00:13:34,200 --> 00:13:39,640
+transplantation، فيه إن الفحوصات بتتم لـ هذا
+
+164
+00:13:39,640 --> 00:13:45,040
+المريض، اللي هي الـ C-peptide، والانسولين، يعني للتأكد
+
+165
+00:13:45,040 --> 00:13:52,500
+أن هذه الخلايا اللي تم زراعتها، تعمل بالشكل
+
+166
+00:13:53,150 --> 00:13:57,950
+المطلوب منها
+
+167
+00:13:57,950 --> 00:14:04,610
+الفحوصات اللي بتتم لمتابعة مرضى السكري، إنها زي ما
+
+168
+00:14:04,610 --> 00:14:12,030
+ذكرنا، فيه الـ glucose، الـ fasting أو الـ random، طبعًا
+
+169
+00:14:12,030 --> 00:14:15,030
+في الـ blood أو في الـ urine، فيه الـ glycated
+
+170
+00:14:15,030 --> 00:14:20,150
+proteins، اللي هي الـ proteins اللي ارتبطت معها الـ
+
+171
+00:14:20,150 --> 00:14:23,570
+glucose، يعني الـ hemoglobin A1c، اللي طبعًا الأكثر
+
+172
+00:14:23,570 --> 00:14:29,890
+شهرة، فيه fructosamine، وفيه أيضًا glycated serum
+
+173
+00:14:29,890 --> 00:14:31,070
+albumin
+
+174
+00:14:33,480 --> 00:14:39,260
+يعني أيضًا 1,5-anhydroglucitol، أو 1,5-
+
+175
+00:14:39,260 --> 00:14:43,640
+AG. فيه برضه الـ urinary proteins، اللي هو
+
+176
+00:14:43,640 --> 00:14:48,840
+البول، زي ما قلنا، لمتابعة اللي هو وضع الـ
+
+177
+00:14:48,840 --> 00:14:55,340
+kidney. البول، اللي هو الدارج عندنا الاسم، أو
+
+178
+00:14:55,340 --> 00:15:00,320
+معروف أكثر بـ microalbuminuria، لكن الآن يعني يفضل
+
+179
+00:15:00,320 --> 00:15:03,720
+أن يتم تسميته بالـ proteinuria، زي ما هنشوف
+
+180
+00:15:03,720 --> 00:15:09,180
+proteinuria، الـ proteins في الـ urine، و evaluation
+
+181
+00:15:09,180 --> 00:15:15,620
+of complications. اللي هو من خلال قياس الـ creatinine
+
+182
+00:15:15,620 --> 00:15:19,780
+لـ kidney function، وعندنا الكوليسترول، والـ tri-
+
+183
+00:15:19,780 --> 00:15:26,100
+glycerides، يعني ممكن عشان نشوف اللي هو الـ risk
+
+184
+00:15
+
+223
+00:18:26,010 --> 00:18:30,650
+Hemoglobin A1B و Hemoglobin A1C تمام؟ فهذول الثلاثة
+
+224
+00:18:30,650 --> 00:18:35,570
+يُطلق عليهم Hemoglobin A1 من هذول الثلاثة عندنا ال
+
+225
+00:18:35,570 --> 00:18:39,790
+major fraction هو الـ Hemoglobin A1C و الذي يمثل
+
+226
+00:18:39,790 --> 00:18:42,010
+80%
+
+227
+00:18:44,730 --> 00:18:48,250
+طبعاً في عندنا أيضاً يعني أنواع أخرى مثل الـ
+
+228
+00:18:48,250 --> 00:18:52,370
+Hemoglobin مثلاً A1A الذي هو عبارة عن Hemoglobin A
+
+229
+00:18:52,370 --> 00:18:58,830
+مرتبط مع Fructose Hemoglobin A1A2 الذي هو
+
+230
+00:18:58,830 --> 00:19:03,870
+Hemoglobin A مرتبط مع Glucose 6-Phosphate تمام، يعني
+
+231
+00:19:03,870 --> 00:19:08,030
+في أنواع مختلفة لكن النسبة الأكبر هي الـ
+
+232
+00:19:08,030 --> 00:19:14,500
+Hemoglobin A1C و هي التي تُقاس الـ
+
+233
+00:19:14,500 --> 00:19:19,580
+Formation، وطبعاً هذه نقطة مهمة الـ Formation of
+
+234
+00:19:19,580 --> 00:19:23,560
+Glycated Hemoglobin is essentially irreversible
+
+235
+00:19:23,560 --> 00:19:29,500
+و إلا إذا كان reversible، يعني لن يكون دقيقاً
+
+236
+00:19:29,500 --> 00:19:33,480
+لاستخدامه. يبقى الـ Glycated Hemoglobin is
+
+237
+00:19:33,480 --> 00:19:37,560
+essentially irreversible،  مازال صار فينا ارتباط بين
+
+238
+00:19:37,560 --> 00:19:41,920
+الجلوكوز و بين الـ Hemoglobin، يبقى لن يصير فيه
+
+239
+00:19:41,920 --> 00:19:47,920
+ما هو effect للجلوكوز مرة أخرى. The concentration
+
+240
+00:19:47,920 --> 00:19:51,500
+in the blood depends on both the lifespan of the
+
+241
+00:19:51,500 --> 00:19:54,880
+red blood cells، هذا الذي يعتمد عليه نسبة
+
+242
+00:19:54,880 --> 00:19:59,380
+لجليكيت الـ Hemoglobin، الذي هو عمر الخلايا الدم
+
+243
+00:19:59,380 --> 00:20:06,040
+الحمراء و الـ Blood Glucose Concentration في
+
+244
+00:20:06,040 --> 00:20:12,480
+الدم، يبقى هاتان النقطتان اللتان يُعتمد عليهما نسبة الـ
+
+245
+00:20:12,480 --> 00:20:19,200
+Glycated Hemoglobin في الدم،
+
+246
+00:20:19,200 --> 00:20:22,820
+يبقى عندنا الـ Glucose
+
+247
+00:20:25,970 --> 00:20:32,330
+طبعاً يرتبط على الـ N-terminal amino group لـ
+
+248
+00:20:32,330 --> 00:20:41,250
+الـ beta-chain، بداية يكون أن  الـ dimine عبارة عن
+
+249
+00:20:41,250 --> 00:20:48,210
+Schiff base، و بعد ذلك الـ aldamine هذه تتحول إلى
+
+250
+00:20:48,210 --> 00:20:54,130
+ketoamine الذي هو الـ hemoglobin A1C، يبقى يصير في
+
+251
+00:20:54,130 --> 00:20:59,590
+عندنا rearrangement للـ aldamine و يعطيني ketoamine
+
+252
+00:20:59,590 --> 00:21:04,050
+الذي هو الـ hemoglobin A1C. يبقى الـ hemoglobin A مع
+
+253
+00:21:04,050 --> 00:21:10,470
+الـ glucose يعطيني pre-hemoglobin A1C، وهذه الخطوة
+
+254
+00:21:10,470 --> 00:21:17,110
+كما هو واضح، هذه الخطوة reversible تماماً، فالخطوة
+
+255
+00:21:17,110 --> 00:21:20,390
+هذه reversible لكن بعد ذلك pre-hemoglobin A1C
+
+256
+00:21:20,390 --> 00:21:25,490
+يصير فيه عندنا rearrangement لهذا المركب تماماً
+
+257
+00:21:25,490 --> 00:21:30,790
+و يعطيني hemoglobin A1C، وهذه الخطوة irreversible
+
+258
+00:21:30,790 --> 00:21:34,990
+كما نحن نرى، السهم في اتجاه واحد فقط
+
+259
+00:21:37,890 --> 00:21:41,030
+بالنسبة للارتباط الذي يصير بين الجلوكوز و بين
+
+260
+00:21:41,030 --> 00:21:45,330
+الهيموجلوبين، plasma glucose in the preceding one
+
+261
+00:21:45,330 --> 00:21:48,590
+month determines fifty percent of the hemoglobin
+
+262
+00:21:48,590 --> 00:21:53,290
+A1C. يعني لو جئنا وقلنا على ثلاثة أشهر، ممكن بالشهر
+
+263
+00:21:53,290 --> 00:21:58,110
+الأول تكون كمية الارتباط قليلة، بالشهر الثاني
+
+264
+00:21:58,110 --> 00:22:02,650
+تزيد، و بالشهر الثالث تكون هي أكثَر نسبة
+
+265
+00:22:02,650 --> 00:22:05,350
+وبالتالي plasma glucose in the preceding one month
+
+266
+00:22:06,490 --> 00:22:11,890
+الذي يُشَكِّل 50% من الهيموجلوبين A1C الآن.
+
+267
+00:22:11,890 --> 00:22:17,150
+الشهر الذي قبله تكون عندي نسبة خمسة
+
+268
+00:22:17,150 --> 00:22:22,810
+و عشرين بالمئة، و الذي هو طبعاً الشهر الذي قبله أو
+
+269
+00:22:22,810 --> 00:22:26,170
+الشهران اللذان قبله تكون عندنا الخمسة و العشرون بالمئة
+
+270
+00:22:26,170 --> 00:22:31,850
+الـ باقية، الـ interpretation لـ Glycated
+
+271
+00:22:31,850 --> 00:22:33,910
+الهيموجلوبين depends on red blood cells لأننا
+
+272
+00:22:33,910 --> 00:22:39,790
+نتحدث عن الارتباط للجلوكوز مع الـ Beta-Chain في
+
+273
+00:22:39,790 --> 00:22:41,710
+الهيموجلوبين الموجود في الـ Red Blood Cells
+
+274
+00:22:41,710 --> 00:22:46,230
+وبالتالي أي شيء سيؤثر على عمر الـ Red Blood Cells
+
+275
+00:22:46,230 --> 00:22:50,930
+أكيد سيؤثر على الـ Glycated Hemoglobin. إذا كانت
+
+276
+00:22:50,930 --> 00:22:55,690
+المريضة مصابة بمرض انحلال دم أو أشياء أخرى مع تقصير حياة
+
+277
+00:22:55,690 --> 00:23:01,190
+الـ Red Blood Cells، تظهر قيم Glycated
+
+278
+00:23:01,190 --> 00:23:05,870
+Hemoglobin أيضاً. إذا كان صار فيه أن
+
+279
+00:23:05,870 --> 00:23:10,010
+significant blood loss، يبقى individuals with
+
+280
+00:23:10,010 --> 00:23:14,390
+recent significant blood loss، أيضاً هذا ممكن يعطيني
+
+281
+00:23:14,390 --> 00:23:19,250
+أيضاً قِيَم falsely low values، يبقى ممكن نأتي و نفحص و
+
+282
+00:23:19,250 --> 00:23:23,510
+نجد أن الـ hemoglobin A1c الذي يعني منخفض، لكن
+
+283
+00:23:23,510 --> 00:23:27,550
+هذا سيكون falsely low لأنه صار في عندي فقط لا كمية
+
+284
+00:23:27,550 --> 00:23:31,370
+كبيرة من الدم
+
+285
+00:23:33,110 --> 00:23:37,230
+و الذي هو طبعاً الـ high fraction of younger
+
+286
+00:23:37,230 --> 00:23:43,690
+erythrocytes التي لم يحصل فيها ارتباط للجلوكوز
+
+287
+00:23:43,690 --> 00:23:50,050
+بكميات جيدة،  high Glycated
+
+288
+00:23:50,050 --> 00:23:53,470
+الهيموجلوبين، أيضاً هذا من ناحية أخرى ممكن يصير فينا
+
+289
+00:23:53,470 --> 00:23:57,570
+ارتفاع لـ Glycated الهيموجلوبين في حالات الـ iron
+
+290
+00:23:57,570 --> 00:24:00,930
+deficiency anemia، يبقى في الـ Iron deficiency
+
+291
+00:24:00,930 --> 00:24:03,770
+anemia، التي هي نجد أن إذا  ارتفع الـ
+
+292
+00:24:03,770 --> 00:24:08,130
+concentration، لكن الـ mechanism و كيف يصير
+
+293
+00:24:08,130 --> 00:24:11,050
+هذا الأمر is unknown
+
+294
+00:24:13,780 --> 00:24:17,100
+طبعاً كما قلنا أن الـ Hemoglobin A1C أو الـ
+
+295
+00:24:17,100 --> 00:24:21,060
+Glycated Protein بشكل عام، من  الفحوصات التي تُجرى
+
+296
+00:24:21,060 --> 00:24:27,420
+بصورة دورية، وفعلياً العديد
+
+297
+00:24:27,420 --> 00:24:32,920
+من المنظمات التي معنية بهذا المرض، والتي
+
+298
+00:24:32,920 --> 00:24:38,480
+تُعتبر مؤثرة، توصي بفحص الـ Hemoglobin
+
+299
+00:24:38,480 --> 00:24:42,060
+A1C بشكل روتيني
+
+300
+00:24:43,260 --> 00:24:46,320
+to document degree of glycemic control and to
+
+301
+00:24:46,320 --> 00:24:50,620
+assess response to treatment، لكي نرى مدى الـ
+
+302
+00:24:50,620 --> 00:24:53,080
+التزام، كما قلنا، و يَبيّن مستويات
+
+303
+00:24:53,080 --> 00:24:59,160
+السكر عند المريض، و أيضاً استجابة المريض للعلاج
+
+304
+00:25:01,150 --> 00:25:04,390
+الـ Absolute risk of retinopathy and nephropathy
+
+305
+00:25:04,390 --> 00:25:07,710
+were directly proportional to the mean hemoglobin
+
+306
+00:25:07,710 --> 00:25:11,270
+A1C concentration.  عِلمًا جاء من خلال الـ hemoglobin
+
+307
+00:25:11,270 --> 00:25:17,770
+A1C، أيضاً ممكن نرى الـ risk للمريض للإصابة بالـ
+
+308
+00:25:17,770 --> 00:25:21,550
+complications المختلفة، و من خلال الدراسات وجد أن
+
+309
+00:25:21,550 --> 00:25:25,150
+each one percent reduction in hemoglobin A1C، يعني
+
+310
+00:25:25,150 --> 00:25:31,910
+على سبيل المثال، كان 8%  انخفاض، كان هذا مصحوباً بـ
+
+311
+00:25:31,910 --> 00:25:39,290
+reduction of 37% for microvascular disease، و أيضاً
+
+312
+00:25:39,290 --> 00:25:44,170
+كان فينا 21% for death related to diabetes، كان في
+
+313
+00:25:44,170 --> 00:25:48,810
+انخفاض أيضاً، reduction بنسبة 21%، و أيضاً كان
+
+314
+00:25:48,810 --> 00:25:53,860
+في reduction بنسبة 14% للـ myocardial infarction
+
+315
+00:25:53,860 --> 00:26:00,020
+يبقى 1% له تأثير كبير في تقليل الـ complications
+
+316
+00:26:00,020 --> 00:26:09,040
+المختلفة.  في طرق عديدة للفحص لـ Glycated
+
+317
+00:26:09,040 --> 00:26:11,900
+الهيموجلوبين، منها الـ hemoglobin A1C، more than
+
+318
+00:26:11,900 --> 00:26:18,110
+150 different methods have been described. الـ ADA
+
+319
+00:26:18,110 --> 00:26:21,750
+تُرجِّح أن المختبرات تستخدم فقط الـ Hemoglobin A1c
+
+320
+00:26:21,750 --> 00:26:28,530
+أساليب تتعامل مع الـ NGSP،  يقول لنا لازم تكون الـ
+
+321
+00:26:28,530 --> 00:26:33,350
+أساليب مُوَحَّدة مع  certified method، التي نريد
+
+322
+00:26:33,350 --> 00:26:40,030
+أن نستخدمها سواء للتشخيص أو للعلاج
+
+323
+00:26:40,030 --> 00:26:41,710
+الطبي
+
+324
+00:26:43,870 --> 00:26:50,550
+و عليه على الموقع الإلكتروني للـ NGSP موجود
+
+325
+00:26:50,550 --> 00:26:58,090
+الطرق المعتمدة من قبلهم، بالنسبة
+
+326
+00:26:58,090 --> 00:27:01,470
+لنتيجة الـ hemoglobin A1C reported as a percentage
+
+327
+00:27:01,470 --> 00:27:05,690
+و هذا يعني الذي يُستَخدَم عندنا of total hemoglobin
+
+328
+00:27:07,250 --> 00:27:11,630
+هذا بناءً على الـ NGSP System، لكن في عندنا أيضاً
+
+329
+00:27:11,630 --> 00:27:15,050
+وحدات أخرى ممكن تستخدم، بناءً على الـ
+
+330
+00:27:15,050 --> 00:27:17,330
+International Federation of Clinical Chemistry
+
+331
+00:27:17,330 --> 00:27:23,990
+و هذه الوحدات هي ملي مول لكل مول، ملي مول
+
+332
+00:27:23,990 --> 00:27:30,010
+Hemoglobin لكل مول من الـ hemoglobin
+
+333
+00:27:30,010 --> 00:27:35,310
+Multinational
+
+334
+00:27:35,310 --> 00:27:36,650
+Prospective Study
+
+335
+00:27:39,860 --> 00:27:44,500
+و أظهرت العلاقة بين قيمة الهيموغلوبين A1C و قيمة
+
+336
+00:27:44,500 --> 00:27:49,920
+الهيموغلوبين A1C و قيمة الهيموغلوبين A1C و قيمة
+
+337
+00:27:49,920 --> 00:27:58,040
+الهيموغلوبين A1C و قيمة
+
+338
+00:27:58,040 --> 00:28:06,320
+الهيموغلوبين A1C و قيمة الهيموغلوبين A1C، وبالتالي
+
+339
+00:28:06,320 --> 00:28:09,060
+مازال لدينا correlation، يمكن من خلال
+
+340
+00:28:09,060 --> 00:28:13,760
+الـ percentage للـ hemoglobin A1C ممكن نحدد قيمة
+
+341
+00:28:13,760 --> 00:28:19,100
+أو نعمل estimation لـ average glucose عند هذا
+
+342
+00:28:19,100 --> 00:28:25,300
+المريض، و من خلال هذه العلاقة قاموا بوضع الـ
+
+343
+00:28:25,300 --> 00:28:30,060
+regression equation التي
+
+344
+00:28:30,060 --> 00:28:35,610
+هي الـ formula عندنا، الـ Estimated Average Glucose
+
+345
+00:28:35,610 --> 00:28:41,630
+بالميلي غرام بالديسيلتر تساوي 28.7 ضرب Hemoglobin
+
+346
+00:28:41,630 --> 00:28:47,070
+A1C ناقص 46.7
+
+347
+00:28:48,910 --> 00:28:53,990
+فحص آخر الذي  ممكن يُستخدم للـ intermediate term،
+
+348
+00:28:53,990 --> 00:28:57,770
+رأينا أن glucose للـ short term و أن
+
+349
+00:28:57,770 --> 00:29:01,490
+الجليكيت الهيموجلوبين للـ long term، و هنا عندنا
+
+350
+00:29:01,490 --> 00:29:08,230
+الـ 1,5-anhydroglucitol للـ intermediate
+
+351
+00:29:08,230 --> 00:29:18,950
+term، و من خلال فحصنا للـ 1,5-AG، ممكن هذا يعكس لنا كم
+
+352
+00:29:18,950 --> 00:29:23,730
+كانت glucose concentration في اليومين إلى 14
+
+353
+00:29:23,730 --> 00:29:33,370
+يوم السابقين.  الـ 15AG هو عبارة عن Deoxy Form of
+
+354
+00:29:33,370 --> 00:29:36,770
+Glucose، كما هو واضح أنه يُشتق من الجلوكوز
+
+355
+00:29:36,770 --> 00:29:42,490
+تماماً، بنزع الـ OH group،  يتحول إلى 1,5
+
+356
+00:29:42,490 --> 00:29:44,410
+-anhydroglucitol
+
+357
+00:29:46,610 --> 00:29:52,490
+من أين يأتي الـ 1,5-anhydroglucitol؟ originates
+
+358
+00:29:52,490 --> 00:29:57,750
+predominantly from the diet، يبقى عندنا الكمية
+
+359
+00:29:57,750 --> 00:30:03,170
+الأكبر، الأعظم، تأتي من الـ diet، هو أكثر من 99.9%
+
+360
+00:30:06,060 --> 00:30:13,620
+الآن، الـ 1,5-anhydroglucitol يخضع لـ filtration، و
+
+361
+00:30:13,620 --> 00:30:17,120
+بعد ذلك يعود طبعاً في الـ  الكلى، و بعد ذلك يعود
+
+362
+00:30:17,120 --> 00:30:24,420
+بواسطة reabsorption عن طريق الـ SGLT4، التي هي Sodium
+
+363
+00:30:24,420 --> 00:30:27,040
+Dependent Glucose Transporter
+
+364
+00:30:29,450 --> 00:30:36,210
+في بعض الدراسات التي أجريت،  و التي استخدمت
+
+365
+00:30:36,210 --> 00:30:42,500
+فيها الـ اللعاب، لقياس الـ 1,5 AG
+
+366
+00:30:42,500 --> 00:30:48,300
+و وجدوا أنه ممكن فحص الـ 1,5 AG في اللعاب
+
+367
+00:30:48,300 --> 00:30:56,120
+ممكن أن يعكس كمية الـ 1,5 AG في الدم
+
+368
+00:30:56,120 --> 00:31:01,040
+وبالتالي، يعني ممكن فحص الـ 1,5 AG في اللعاب
+
+369
+00:31:02,070 --> 00:31:07,630
+يعني أنا ممكن أكون للـ intermediate كما
+
+370
+00:31:07,630 --> 00:31:11,650
+قلنا term of monitoring، لكن يمكن هذا يحتاج إلى
+
+371
+00:31:11,650 --> 00:31:14,630
+more research
+
+372
+00:31:18,410 --> 00:31:22,230
+عندما تتجاوز موارد الجلوكوز موارد الكلى
+
+373
+00:31:22,230 --> 00:31:24,850
+تتجاوز موارد الكلى تتجاوز موارد الكلى تتجاوز
+
+374
+00:31:24,850 --> 00:31:31,970
+موارد الكلى تتجاوز موارد الكلى تتجاوز موارد
+
+375
+00:31:31,970 --> 00:31:38,970
+الكلى تتجاوز موارد الكلى تتجاوز موارد الكلى
+
+376
+00:31:38,970 --> 00:31:39,490
+تتجاوز موارد الكلى تتجاوز موارد الكلى تتجاوز
+
+377
+00:31:39,490 --> 00:31:43,810
+موارد الكلى تتجاوز موارد الكلى تتجاوز موارد
+
+378
+00:31:43,810 --> 00:31:50,610
+الكلى تتجاوز موارد الكلى تتجاوز مو هذا يؤدي
+
+379
+00:31:50,610 --> 00:31:59,450
+إلى انخفاض مستوى الـ 1,5 AG في الدم. يبقى إذا كان
+
+380
+00:31:59,450 --> 00:32:06,490
+صار في عندي ارتفاع في الجلوكوز تماماً، و تجاوز الـ
+
+381
+00:32:06,490 --> 00:32:13,150
+حاجز 180،  معناته سيصير عندنا نقص في الـ
+
+382
+00:32:13,150 --> 00:32:18,010
+reabsorption للـ 1,5 AG، وهذا سيؤدي إلى انخفاض الـ 1
+
+383
+00:32:18,010 --> 00:32:25,430
+,5-AG في الدم. يبقى بالتالي low 1,5-AG indicates
+
+384
+00:32:25,430 --> 00:32:30,910
+hyperglycemia. إذا انخفض عندنا مستوى الـ 1,5-AG في
+
+385
+00:32:30,910 --> 00:32:34,830
+الدم، معناته هذا يعني أن هذا الشخص لديه
+
+386
+00:32:34,830 --> 00:32:39,730
+hyperglycemia correlated particularly with
+
+387
+00:32:39,730 --> 00:32:44,090
+postprandial blood glucose concentration
+
+388
+00:32:46,800 --> 00:32:53,920
+فيه جهاز تمّ عمله لقياس الـ 1,5 AG، Automated
+
+389
+00:32:53,920 --> 00:33:00,120
+Calorimetric Assay، وهذا الجهاز approved من الـ FDA
+
+390
+00:33:00,120 --> 00:33:07,200
+الذي يسمى الـ Glycomark، يمكن من خلاله نرى الـ
+
+391
+00:33:07,200 --> 00:33:12,380
+concentration للـ 1,5 AG، وبالتالي نحدد
+
+392
+00:33:12,380 --> 00:33:17,280
+مستوى الجلوكوز عند الشخص، كما قلنا، في
+
+393
+00:33:17,280 --> 00:33:24,460
+اليومين إلى أربعة عشر يوماً السابقين. ومن
+
+394
+00:33:24,460 --> 00:33:32,290
+خلال دراسة و التي قورنت مع الـ hemoglobin A1C، يعني
+
+395
+00:33:32,290 --> 00:33:38,630
+تبين أن الـ 1,5 AG ممكن يُكشف عن بعض الحالات
+
+396
+00:33:38,630 --> 00:33:48,990
+التي فعلياً فيها ارتفاع في مستوى
+
+397
+00:33:48,990 --> 00:33:53,770
+الجلوكوز، Spikes، يعني كما قلنا
+
+398
+00:33:53,770 --> 00:33:59,950
+postprandial Spikes من الـ Hyperglycemia
+
+399
+00:34:01,330 --> 00:34:04,510
+و هنا عندنا مثال، عندنا هنا patient
+
+400
+00:34:04,510 --> 00:34:12,550
+fifty year old female، و الـ hemoglobin A1c فحصوه
+
+401
+00:34:12,550 --> 00:34:20,630
+وجدو 7.4 بالمئة، و عندما فحصوا الـ
+
+402
+00:34:20,630 --> 00:34:24,
+
+445
+00:38:28,420 --> 00:38:33,420
+ثلاثمائة milligram اللي هو في الأربع وعشرين ساعة
+
+446
+00:38:33,420 --> 00:38:40,100
+في الـ type one، الـ type two diabetes mellitus برضه
+
+447
+00:38:40,100 --> 00:38:44,160
+microalbuminuria occurred in 38 percent of
+
+448
+00:38:44,160 --> 00:38:49,350
+participants in a cohort study. يبقى الـ type one و
+
+449
+00:38:49,350 --> 00:38:53,730
+الـ type two طبعا يعني من الـ complications أنه يصير
+
+450
+00:38:53,730 --> 00:38:59,170
+في عندنا اللي هو microalbuminuria، واللي ممكن تتطور
+
+451
+00:38:59,170 --> 00:39:02,090
+إليه برضه macroalbuminuria
+
+452
+00:39:04,610 --> 00:39:08,370
+التحقق من الـ diabetic nephropathy يعتمد على تجارب
+
+453
+00:39:08,370 --> 00:39:10,650
+تجارب ألبومينية.
+
+454
+00:39:10,650 --> 00:39:13,110
+
+455
+00:39:13,110 --> 00:39:15,890
+
+456
+00:39:15,890 --> 00:39:19,850
+
+457
+00:39:19,850 --> 00:39:20,590
+
+458
+00:39:20,590 --> 00:39:20,630
+
+459
+00:39:20,630 --> 00:39:21,610
+
+460
+00:39:21,610 --> 00:39:25,070
+تجارب ألبومينية، يتم تجارب الكلى، وبنشوف إذا
+
+461
+00:39:25,070 --> 00:39:31,070
+في عندنا يعني بدأت الـ... ممكن الـ nephropathy أو
+
+462
+00:39:31,070 --> 00:39:35,730
+بدأ يصير في عندنا خلل في الكلى. Persistent
+
+463
+00:39:35,730 --> 00:39:38,930
+proteinuria detectable by routine screening
+
+464
+00:39:43,120 --> 00:39:46,260
+الـ persistent اللي هو proteinuria أو اللي هو
+
+465
+00:39:46,260 --> 00:39:49,640
+سمّيناها الـ macroproteinuria detectable by routine
+
+466
+00:39:49,640 --> 00:39:54,020
+screening test. الألبومين اللي هو excretion rate
+
+467
+00:39:54,020 --> 00:39:57,360
+أكثر من 200 ميكروجرام لكل دقيقة، أو اللي هو أكثر
+
+468
+00:39:57,360 --> 00:40:03,900
+من 300 مليجرام زي ما حكينا في الأربع وعشرين ساعة طبعا
+
+469
+00:40:03,900 --> 00:40:06,660
+إذا كان في عندنا persistent proteinuria، أو اللي هو
+
+470
+00:40:06,660 --> 00:40:12,620
+macroalbuminuria، معناته هذا بيوحي أنه
+
+471
+00:40:12,620 --> 00:40:15,820
+في عندنا overt diabetic nephropathy
+
+472
+00:40:18,000 --> 00:40:20,720
+طبعا هذا يعني من الـ... أكيد اللي هو الـ long term
+
+473
+00:40:20,720 --> 00:40:24,300
+complications associated with long-standing
+
+474
+00:40:24,300 --> 00:40:29,220
+disease. Once diabetic nephropathy occurs, renal
+
+475
+00:40:29,220 --> 00:40:33,260
+function deteriorates rapidly and renal
+
+476
+00:40:33,260 --> 00:40:38,220
+insufficiency evolves. وطبعا ممكن ينتهي المريض بـ
+
+477
+00:40:38,220 --> 00:40:42,040
+اللي هو end-stage renal disease و renal failure
+
+478
+00:40:42,920 --> 00:40:46,360
+Treatment at this stage can retard the rate of
+
+479
+00:40:46,360 --> 00:40:50,240
+progression without stopping or reversing the
+
+480
+00:40:50,240 --> 00:40:56,320
+renal damage. عشان
+
+481
+00:40:56,320 --> 00:41:05,020
+هيك طبعا، المتابعة مهمة، يعني أنه نكشف عن وجود الـ
+
+482
+00:41:05,020 --> 00:41:08,000
+... الـ... الـ albuminuria، أو زي ما قلنا كانت يعني
+
+483
+00:41:08,000 --> 00:41:12,460
+تسمى سابقا microalbuminuria، وبالتالي يعني ممكن
+
+484
+00:41:12,460 --> 00:41:18,520
+يكون فيه فرصة للتدخل ومنع حدوث الـ... الـ renal
+
+485
+00:41:18,520 --> 00:41:19,640
+failure
+
+486
+00:41:22,040 --> 00:41:24,860
+يبقى preceding this stage، اللي قبل مرحلة الـ
+
+487
+00:41:24,860 --> 00:41:28,200
+macroalbuminuria، فيه أنه مرحلة of increased
+
+488
+00:41:28,200 --> 00:41:32,720
+albumin excretion rate not detected by routine
+
+489
+00:41:32,720 --> 00:41:36,720
+dipstick methods. يبقى بالطريقة اللي هو العادية
+
+490
+00:41:36,720 --> 00:41:40,560
+اللي بنفحص فيها الـ protein، والـ dipstick مش ممكن
+
+491
+00:41:40,560 --> 00:41:45,140
+أن نقدر نعمل detection لهذه الكميات القليلة من
+
+492
+00:41:45,530 --> 00:41:48,430
+الألبومين اللي يتراوح بين عشرين إلى مئتين microgram
+
+493
+00:41:48,430 --> 00:41:52,270
+في الدقيقة، أو ثلاثين إلى ثلاثمائة milligram لكل
+
+494
+00:41:52,270 --> 00:41:57,090
+اللي هو الأربع وعشرين ساعة تماما، وهذه المرحلة اللي
+
+495
+00:41:57,090 --> 00:42:02,610
+قلنا microalbuminuria، أو albuminuria. Current
+
+496
+00:42:02,610 --> 00:42:04,490
+nomenclature has eliminated the term
+
+497
+00:42:04,490 --> 00:42:09,750
+microalbuminuria. إن macroalbuminuria يعني الآن لأنه
+
+498
+00:42:09,750 --> 00:42:14,610
+يعني ممكن تفهم خطأ اللي هي microalbuminuria تماما
+
+499
+00:42:14,610 --> 00:42:17,330
+أنه بنحكي يعني عن albumin اللي هو ممكن يكون يعني
+
+500
+00:42:17,330 --> 00:42:22,790
+micro، أو يعني صغير، واستبدلوه بالـ albuminuria، لكن
+
+501
+00:42:22,790 --> 00:42:26,110
+لغاية الآن يعني ناس كثير بتستخدم اللي هو الـ micro
+
+502
+00:42:26,110 --> 00:42:29,010
+albuminuria والـ macroalbuminuria
+
+503
+00:42:31,210 --> 00:42:33,510
+تمام. يبقى السبب زي ما قلنا إن الـ macroalbuminuria
+
+504
+00:42:33,510 --> 00:42:37,850
+يعني ممكن يكون misleading، آه يعني ما بيتفهم
+
+505
+00:42:37,850 --> 00:42:42,310
+المصطلح بشكل صحيح. implies a small version of the
+
+506
+00:42:42,310 --> 00:42:45,970
+albumin molecule rather than an excretion rate of
+
+507
+00:42:45,970 --> 00:42:49,590
+albumin greater than normal but less than detectable
+
+508
+00:42:49,590 --> 00:42:53,570
+by routine methods. يبقى ممكن نفهم إن micro معناته
+
+509
+00:42:53,570 --> 00:42:57,910
+إن في عندنا يعني زي نسخة، لكن اللي هي أصغر، ممكن من
+
+510
+00:42:57,910 --> 00:43:03,180
+الـ albumin الطبيعي. وبتاع، علشان هيك اللي هو الـ micro
+
+511
+00:43:03,180 --> 00:43:07,240
+albuminuria، يعني لا يُحبّذ استخدام هذا المصطلح، لكن
+
+512
+00:43:07,240 --> 00:43:12,180
+إحنا الدارج اللي... اللي فعليا بيستخدم هو الـ micro
+
+513
+00:43:12,180 --> 00:43:18,020
+albuminuria طبعا
+
+514
+00:43:18,020 --> 00:43:27,180
+المشكلة هون أنه بيصير في عندنا مرور لـ الـ albumin عبر
+
+515
+00:43:28,810 --> 00:43:32,310
+الـ glomerulus، هي عبارة عن tuft of capillaries
+
+516
+00:43:32,310 --> 00:43:35,830
+زي ما أنتم عارفين، واللي من خلالها بيصير عملية الـ
+
+517
+00:43:35,830 --> 00:43:44,710
+wall filtration للـ blood، وفي عندنا طبعا يعني اللي
+
+518
+00:43:44,710 --> 00:43:51,610
+هي الـ proteins اللي molecular weight أقل
+
+519
+00:43:51,610 --> 00:43:51,890
+من
+
+520
+00:43:54,810 --> 00:44:01,290
+تقريبا ستين كيلودالتون، يبقى الـ... إذا كان أكبر من
+
+521
+00:44:01,290 --> 00:44:05,430
+ستين كيلودالتون يبقى ما بيسلّحهوش filtration، بفضل موجود
+
+522
+00:44:05,430 --> 00:44:09,050
+بالدم، إذا أقل ممكن يسلك filtration، الآن بيصير
+
+523
+00:44:09,050 --> 00:44:15,290
+في عندنا مشكلة في الـ... الـ pores الموجودة في الـ
+
+524
+00:44:15,290 --> 00:44:21,790
+capillaries، وبالتالي هذا بيسمح بمرور اللي هو
+
+525
+00:44:21,790 --> 00:44:26,290
+proteins اللي الـ molecular weight بتاعتها أكبر من
+
+526
+00:44:26,290 --> 00:44:31,310
+ستين كيلودالتون، اللي هو زي الـ albumin، وبالتالي
+
+527
+00:44:31,310 --> 00:44:37,710
+بنلاقي أنه بدأ يصير في عندنا concentration أعلى من هذه
+
+528
+00:44:37,710 --> 00:44:44,590
+الـ proteins في الـ urine. يبقى متابعتنا لكميات
+
+529
+00:44:44,590 --> 00:44:49,610
+الألبومين اللي بتسلك excretion في الـ urine بتعطي
+
+530
+00:44:49,610 --> 00:44:55,070
+indication عن حالة الـ microvessels في الكلى
+
+531
+00:44:55,070 --> 00:45:00,130
+وبالتالي الـ risk للإصابة بالـ diabetic
+
+532
+00:45:00,130 --> 00:45:04,310
+nephropathy، أو يعني مستقبلا بالـ end-stage renal
+
+533
+00:45:04,310 --> 00:45:08,250
+disease. يبقى persistent albumin excretion rate
+
+534
+00:45:08,250 --> 00:45:12,410
+greater than 20 microgram per minute represents a
+
+535
+00:45:12,410 --> 00:45:16,330
+twenty-fold greater risk for the development of
+
+536
+00:45:16,330 --> 00:45:22,260
+clinically overt renal disease. وإذا كان إن الـ
+
+537
+00:45:22,260 --> 00:45:25,920
+excretion أعلى من عشرين microgram بالدقيقة، يبقى
+
+538
+00:45:25,920 --> 00:45:31,780
+معناته الشخص هذا عنده الـ risk عشرين مرة أكثر
+
+539
+00:45:31,780 --> 00:45:36,880
+لإصابة بالـ kidney disease، وبالـ patients في
+
+540
+00:45:36,880 --> 00:45:44,460
+الـ type 1 أو الـ type 2،وبرضه العديد من الدراسات أكدت
+
+541
+00:45:44,460 --> 00:45:48,240
+هذا الكلام، وأكدت إن الـ increased urinary albumin
+
+542
+00:45:48,240 --> 00:45:50,840
+excretion in patients with diabetes mellitus
+
+543
+00:45:50,840 --> 00:45:54,060
+precedes and is highly predictive of diabetic
+
+544
+00:45:54,060 --> 00:45:56,800
+nephropathy, end-stage renal disease,
+
+545
+00:45:57,400 --> 00:46:02,280
+cardiovascular mortality، والـ total mortality
+
+546
+00:46:02,280 --> 00:46:03,580
+بشكل عام
+
+547
+00:46:06,170 --> 00:46:13,290
+والمتابعة مهمة، لأنه فعليا إذا كان تم الكشف
+
+548
+00:46:13,290 --> 00:46:22,650
+عن الـ albuminuria، يبقى التدخل العلاجي ممكن يقلل
+
+549
+00:46:22,650 --> 00:46:26,730
+من احتمالية إصابة الشخص مستقبلا بـ kidney disease
+
+550
+00:46:26,730 --> 00:46:33,750
+وهذا من خلال دراستين، اللي هو اسمها DCCT و UKPDS
+
+551
+00:46:33,750 --> 00:46:37,910
+هادول الدراستين أظهروا إنه intensive diabetes
+
+552
+00:46:37,910 --> 00:46:41,470
+therapy can significantly reduce the risk of
+
+553
+00:46:41,470 --> 00:46:45,230
+development of increased albumin excretion rate
+
+554
+00:46:45,230 --> 00:46:48,290
+and overt nephropathy in individuals with diabetes
+
+555
+00:46:48,290 --> 00:46:58,730
+يبقى التدخل ممكن فعليا يقلل من اللي هو يعني الـ
+
+556
+00:46:58,730 --> 00:47:03,910
+nephropathy، أو الإصابة بالـ renal disease، عشان
+
+557
+00:47:03,910 --> 00:47:09,810
+هيك المتابعة لمستويات الـ albumin بالـ urine مهمة
+
+558
+00:47:12,210 --> 00:47:17,870
+برضه اللي هو الزيادة في الـ excretion لـ الـ albumin
+
+559
+00:47:17,870 --> 00:47:24,850
+بالـ urine برضه مرتبطة بالـ cardiovascular diseases
+
+560
+00:47:24,850 --> 00:47:28,770
+برضه، وزيادة في الـ albumin excretion rate
+
+561
+00:47:28,770 --> 00:47:32,950
+identifies a group of non-diabetic subjects at
+
+562
+00:47:32,950 --> 00:47:39,830
+increased risk for coronary artery disease. وكمان
+
+563
+00:47:39,830 --> 00:47:44,050
+حتى عند اللي هو الناس ممكن اللي مش مصابين
+
+564
+00:47:44,050 --> 00:47:52,570
+بالـ diabetes، ممكن استخدام هذا الفحص لمعرفة خطر
+
+565
+00:47:52,570 --> 00:47:57,110
+إصابتهم بالـ coronary artery disease من الـ
+
+566
+00:47:57,110 --> 00:47:59,930
+interventions. الـ control of blood glucose
+
+567
+00:47:59,930 --> 00:48:05,250
+concentration و blood pressure، particularly with
+
+568
+00:48:05,250 --> 00:48:09,860
+angiotensin-converting enzyme inhibitors، عشان اللي
+
+569
+00:48:09,860 --> 00:48:15,660
+هي من مخفضة، طبعا أدوية المخفضة لـ الضغط. Slow the
+
+570
+00:48:15,660 --> 00:48:22,580
+rate of decline in renal function. وهنا
+
+571
+00:48:22,580 --> 00:48:25,920
+اللي هو نتائج الدراستين اللي حكينا عليهم، اللي هو
+
+572
+00:48:25,920 --> 00:48:31,720
+الـ DCCT والـ UKPDS، وفي دراسة أخرى أيضا، Kumamoto
+
+573
+00:48:33,340 --> 00:48:36,500
+التخفيض في الـ hemoglobin A1C يعني هون في هذه الدراسة
+
+574
+00:48:36,500 --> 00:48:40,840
+الأولى، من ٩ إلى ٧.٢، قلل الـ incidence of
+
+575
+00:48:40,840 --> 00:48:44,180
+complications للـ retinopathy بنسبة ٦٣٪، نفروباثي
+
+576
+00:48:44,180 --> 00:48:48,740
+بنسبة ٥٤٪، نيوروباثي بنسبة ٦٠٪، والـ cardiovascular
+
+577
+00:48:48,740 --> 00:48:54,380
+disease بنسبة ٤١٪. دراسة ثانية قللوا الـ hemoglobin
+
+578
+00:48:54,380 --> 00:48:58,520
+A1C من ٩ إلى ٧ برضه، هذا قلل من الـ complications
+
+579
+00:48:58,520 --> 00:49:04,700
+بالـ retinopathy والـ nephropathy، وأيضا حسّن من اللي هو
+
+580
+00:49:04,700 --> 00:49:11,940
+يعني عمل اللي هو الأعصاب، أو الـ neurons. والدراسة
+
+581
+00:49:11,940 --> 00:49:16,820
+الثالثة قللوا الـ hemoglobin A1C من ثمانية إلى سبعة
+
+582
+00:49:16,820 --> 00:49:21,940
+وهذا برضه قلل من الـ incidence لـ الـ complications
+
+583
+00:49:21,940 --> 00:49:25,680
+زي الـ retinopathy والـ nephropathy وأيضا الـ
+
+584
+00:49:25,680 --> 00:49:28,440
+cardiovascular disease
+
+585
+00:49:31,150 --> 00:49:34,870
+هيك بنكون أنهينا اللي هي محاضرة الـ diabetes
+
+586
+00:49:34,870 --> 00:49:39,710
+mellitus الجزئين، وبيضل عندنا الـ case studies اللي
+
+587
+00:49:39,710 --> 00:49:46,350
+هنشوف إن شاء الله في اللقاء الوجاهي، ويعطيكم ألف
+
+588
+00:49:46,350 --> 00:49:46,910
+عافية
diff --git a/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/wr_r91FrC-Q_postprocess.srt b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/wr_r91FrC-Q_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..1e9b106ea7e37bb1e459589b3019955a6ec72c95
--- /dev/null
+++ b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/wr_r91FrC-Q_postprocess.srt
@@ -0,0 +1,2352 @@
+1
+00:00:02,700 --> 00:00:06,780
+طيب بما يتعلق بيه ال management ليه ال diabetes
+
+2
+00:00:06,780 --> 00:00:13,900
+patients في عندنا ال acute management يعني للي
+
+3
+00:00:13,900 --> 00:00:19,940
+اللي هو ال acute ممكن cases
+
+4
+00:00:19,940 --> 00:00:25,320
+و في عندنا اللي هو في ال chronic بالنسبة ل ال
+
+5
+00:00:25,320 --> 00:00:33,040
+acute في عندنا من ال ..ال conditions اللي ممكن
+
+6
+00:00:33,040 --> 00:00:37,220
+يصاب فيها ال .. الناس المصابين بالدهبيتاس، فيه أن
+
+7
+00:00:37,220 --> 00:00:41,740
+الدهبات ال ketoacidosis، فيه أن hyperosmolar non
+
+8
+00:00:41,740 --> 00:00:46,540
+-ketotic coma و hypoglycemia
+
+9
+00:00:48,230 --> 00:00:52,410
+طبعا حالات المختلفة هذه أكيد المختبر بيلعب دور مهم
+
+10
+00:00:52,410 --> 00:00:59,250
+في ال diagnosis لهذه الحالات المختلفة وأكيد برضه
+
+11
+00:00:59,250 --> 00:01:04,830
+له دور مهم في المتابعة ومتابعة الألاج اللي هيعطاه
+
+12
+00:01:04,830 --> 00:01:13,010
+للمرضى في هذه الحالات الثلاثة من الفحوصات المختلفة
+
+13
+00:01:13,010 --> 00:01:20,220
+اللي بتتم سواءاللي طبعا بداية ال diagnosis و تحديد
+
+14
+00:01:20,220 --> 00:01:27,420
+العلاج اللازم و لغاية طبعا ما يصل ال glucose
+
+15
+00:01:27,420 --> 00:01:31,940
+concentration يعني فيه اللي هي ال range الطبيعية
+
+16
+00:01:33,330 --> 00:01:37,670
+عندها ال glucose in blood and urine و هذه الفحوصات
+
+17
+00:01:37,670 --> 00:01:41,050
+اللي بتتم فيها ان ال ketones برضه in blood and
+
+18
+00:01:41,050 --> 00:01:45,650
+urine أكيد ال acid base ال status ال pH و ال
+
+19
+00:01:45,650 --> 00:01:51,910
+bicarbonate level اللكتيت و أيضا فحوصات اللي لها
+
+20
+00:01:51,910 --> 00:01:54,730
+علاقة ممكن بال dehydration
+
+21
+00:01:56,660 --> 00:02:00,780
+أو المتعلقة بالعلاج الـ Dialytics السابقة بالمثال
+
+22
+00:02:00,780 --> 00:02:07,360
+في أن البوتاسيوم والسوديوم الفوسفات وأيضا ال
+
+23
+00:02:07,360 --> 00:02:13,840
+Osmolality من هذه الفحصات في أن ال ketone bodies
+
+24
+00:02:13,840 --> 00:02:18,600
+development of ketosis requires changes in both
+
+25
+00:02:18,600 --> 00:02:26,520
+adipose tissue and the liverPrimary substrate for
+
+26
+00:02:26,520 --> 00:02:29,300
+ketone body formation are free fatty acids from
+
+27
+00:02:29,300 --> 00:02:39,480
+adipose stores طبعا ال ketone bodies بتنتج بتم
+
+28
+00:02:39,480 --> 00:02:49,460
+إنتاجها طبعا من خلال ال lipolysis طبعا في نقص في
+
+29
+00:02:49,460 --> 00:02:56,850
+ال insulinلأن الـ Ketosis يعني عادة بتظهر عند اللي
+
+30
+00:02:56,850 --> 00:03:00,010
+هو المرضى بالنوع الأول الـ Type 1 diabetes ماليتاس
+
+31
+00:03:00,630 --> 00:03:05,450
+ونادرا ما نشوف ناس عندهم الـ type 2 diabetes
+
+32
+00:03:05,450 --> 00:03:12,030
+mellitus و عندهم ketosis ليش؟ لأنه الناس اللي هو
+
+33
+00:03:12,030 --> 00:03:14,410
+مرضى الـ type 2 diabetes mellitus في عندهم
+
+34
+00:03:14,410 --> 00:03:18,350
+insulin، ال insulin موجود وبالتالي ال insulin ممكن
+
+35
+00:03:18,350 --> 00:03:23,070
+يعمل inhibition على ال alpha cells و يقلل من
+
+36
+00:03:23,070 --> 00:03:28,480
+الجلوكاجون، لكنبمرضى النوع الاول زى ما حكينا سابقا
+
+37
+00:03:28,480 --> 00:03:33,380
+ان فيانا absolute deficiency of انسولين وبالتالي
+
+38
+00:03:33,380 --> 00:03:37,980
+ال inhibitory effect للانسولين على ال alpha cells
+
+39
+00:03:37,980 --> 00:03:41,960
+مش موجودة وبالتالي ال alpha cells هتنتج glucagon
+
+40
+00:03:41,960 --> 00:03:48,980
+وهيكون فيانا gluconeogenesisبالتالي سيكون هناك
+
+41
+00:03:48,980 --> 00:03:55,100
+breakdown للدهون وإنتاج لكميات كبيرة من ال ketone
+
+42
+00:03:55,100 --> 00:03:56,280
+bodies
+
+43
+00:03:59,780 --> 00:04:04,780
+الدول طبعا يعني بيصير فيها تخزين في الكبد على شكل
+
+44
+00:04:04,780 --> 00:04:09,260
+الـ Triglycerides وطبعا الـ Triglycerides هذه ممكن
+
+45
+00:04:09,260 --> 00:04:12,620
+تحمل على الـ VLDL اللي هو الـ Very Low Density
+
+46
+00:04:12,620 --> 00:04:19,380
+Lipoprotein ويصلها Release لتوزيع Limits على
+
+47
+00:04:19,380 --> 00:04:20,940
+الخلايا
+
+48
+00:04:24,370 --> 00:04:26,590
+بالنسبة الـ In contrast to other tissues، the
+
+49
+00:04:26,590 --> 00:04:30,790
+brain cannot use free fatty acids for energy
+
+50
+00:04:30,790 --> 00:04:35,630
+وبالتالي، في عندنا اللي هو الـ ketone bodies اللي
+
+51
+00:04:35,630 --> 00:04:39,810
+بتتكون و اللي ممكن يستخدمها البرن When glucose is
+
+52
+00:04:39,810 --> 00:04:42,030
+unavailable, ketone bodies supply the vast
+
+53
+00:04:42,030 --> 00:04:48,450
+majority of the brain's energyوإذا كان صار فيه صوم
+
+54
+00:04:48,450 --> 00:04:53,030
+اللي هو لأ تلات أيام ketone bodies provide 30
+
+55
+00:04:53,030 --> 00:04:56,250
+percent to 40 percent of the body's energy
+
+56
+00:04:56,250 --> 00:04:57,410
+requirement
+
+57
+00:04:59,780 --> 00:05:04,780
+يبقى أن الـ ketosis و الارتفاع في ال ketone bodies
+
+58
+00:05:04,780 --> 00:05:09,820
+يعني بيصير في ال uncontrolled diabetes اللي بنحكي
+
+59
+00:05:09,820 --> 00:05:15,060
+على يعني بشكل أخص على اللي هو ال type 1 زي ما
+
+60
+00:05:15,060 --> 00:05:18,260
+قولنا هذا كان في عندنا low insulin concentration
+
+61
+00:05:18,260 --> 00:05:24,540
+هذا حيزيد من ال lipolysis و بالتالي حيزيد من اللي
+
+62
+00:05:24,540 --> 00:05:27,980
+هو ال plasma free fatty acids و اللي هو تكوين ال
+
+63
+00:05:27,980 --> 00:05:34,870
+ketone bodiesHigher Glucagon to Insulin Ratio، طب
+
+64
+00:05:34,870 --> 00:05:37,910
+عاملا أنقولنا اللي هو ان الخفاعة في الانسولين بتخل
+
+65
+00:05:37,910 --> 00:05:39,990
+ال inhibitor effect على ال alpha cells وبالتالي
+
+66
+00:05:39,990 --> 00:05:43,410
+بيصير في ال readers أن لا concentrations أعلى من
+
+67
+00:05:43,410 --> 00:05:46,850
+ال glucagon وبالتالي أن higher glucagon to insulin
+
+68
+00:05:46,850 --> 00:05:50,290
+ratio هذا اللي هو enhances the fatty acid
+
+69
+00:05:50,290 --> 00:05:56,470
+oxidation in the liverعنا أيضًا الزيادة بالهرمونات
+
+70
+00:05:56,470 --> 00:05:58,890
+الأخرى، اللي هو الـ counterregulatory hormones أو
+
+71
+00:05:58,890 --> 00:06:02,190
+اللي هو الـ hyperglycemic hormones، اللي كلها
+
+72
+00:06:02,190 --> 00:06:07,470
+بتزيد من الـ concentration لاللي هو الـ glucose
+
+73
+00:06:07,470 --> 00:06:12,970
+وممكن يعني تساعد فيه أو يعني تعمل اللي هو
+
+74
+00:06:12,970 --> 00:06:19,690
+simulation للـ lipolysis برضه، وبالتالي لتكوين الـ
+
+75
+00:06:19,690 --> 00:06:22,370
+ketone bodies أو الـ ketogenesis
+
+76
+00:06:25,020 --> 00:06:27,820
+من الـ Ketone bodies طبعاً في أن الـ Acetoacetate
+
+77
+00:06:28,970 --> 00:06:31,610
+المجموعة الصغيرة تتكوّن من الـ spontaneous
+
+78
+00:06:31,610 --> 00:06:37,450
+decarboxylation وبتكون عندنا أسيتون ولكن أكتر منها
+
+79
+00:06:37,450 --> 00:06:41,450
+تتحول إلى الـ Beta-hydroxybutyrate وهدول اللي هو
+
+80
+00:06:41,450 --> 00:06:49,250
+التلاتة body كيتون اللي بتكون موجودة في الدم
+
+81
+00:06:49,250 --> 00:06:55,550
+والأسيتون ممكن يطلع مع النفس اللي هو خلال ال
+
+82
+00:06:55,550 --> 00:06:59,560
+exhalationزي ما هو واضح بالفigure هان وإن ال
+
+83
+00:06:59,560 --> 00:07:03,640
+acetoacetate جزء منه بتحول إلى acetone اللي هو عن
+
+84
+00:07:03,640 --> 00:07:07,440
+طريق اللي هو دي carboxylation وإن اللي هو الجزء
+
+85
+00:07:07,440 --> 00:07:13,040
+الأكبر بتحول إلى beta-hydroxybutyrate
+
+86
+00:07:15,670 --> 00:07:19,510
+الزيادة في تكوين ال ketone bodies هيؤدي إلى ارتفاع
+
+87
+00:07:19,510 --> 00:07:22,110
+ال concentration ل ال ketone bodies في الدم
+
+88
+00:07:22,110 --> 00:07:28,830
+وبالتالي هيصير فينا كيتونيميا وأيضا الارتفاع هذا
+
+89
+00:07:28,830 --> 00:07:32,010
+في الدم هيؤدي إلى زيادة ال execution ل ال ketone
+
+90
+00:07:32,010 --> 00:07:36,270
+bodies في ال urine وبالتالي هيكون فينا كيتونوريا
+
+91
+00:07:38,100 --> 00:07:41,320
+ممكن ايضا عندنا ال ketone bodies يعني ايه ممكن
+
+92
+00:07:41,320 --> 00:07:48,540
+تتكون في حالات اللي هو ال .. النقص في ال
+
+93
+00:07:48,540 --> 00:07:51,800
+carbohydrates زي اللي هو the starvation او
+
+94
+00:07:51,800 --> 00:07:56,820
+frequent vomiting او decrease used of
+
+95
+00:07:56,820 --> 00:07:57,820
+carbohydrates
+
+96
+00:08:00,160 --> 00:08:04,520
+زي في حالات اللي هو ال diabetes mellitus أو في
+
+97
+00:08:04,520 --> 00:08:10,180
+حالات اللي هو ال glycogen storage disease type one
+
+98
+00:08:10,180 --> 00:08:17,880
+اللي هو somavone geric diseaseعنا برضه ال .. ال ..
+
+99
+00:08:17,880 --> 00:08:21,440
+ال .. اللي هو ال diet ال .. الموضة اللي هو الآن
+
+100
+00:08:21,440 --> 00:08:27,980
+اللي هو ال keto تمام؟ هذا برضه بيزيد من ال ketone
+
+101
+00:08:27,980 --> 00:08:30,980
+bodies اللي هو ال popular high fat low
+
+102
+00:08:30,980 --> 00:08:33,480
+carbohydrate diet high بيبقى في عنا low
+
+103
+00:08:33,480 --> 00:08:38,060
+carbohydrate هان اللي هو برضه كيتوجينيكوي بيؤدي
+
+104
+00:08:38,060 --> 00:08:42,360
+إلى زيادة في ال ketone bodies في الدم
+
+105
+00:08:45,300 --> 00:08:50,640
+أكتر حالات ال ketoacidosis بنلاقيها عند اللي هو ال
+
+106
+00:08:50,640 --> 00:08:53,220
+diabetes mellitus زي ما قلنا اللي هو بشكل خاص عند
+
+107
+00:08:53,220 --> 00:08:56,780
+اللي هو ال type 1 diabetes mellitus و أيضا عند
+
+108
+00:08:56,780 --> 00:09:01,780
+اللي هو ال .. الناس اللي بيتناولوا يعني كحول
+
+109
+00:09:01,780 --> 00:09:07,740
+بكميات كبيرة وهذا اللي طبعا ال .. ال .. سبب حدوث
+
+110
+00:09:07,740 --> 00:09:13,580
+ال ketoacidosis عند الناس اللي بيتناولوا كحول لأنه
+
+111
+00:09:13,580 --> 00:09:18,570
+بيصير في عندنااللي هو impairment لـ conversion of
+
+112
+00:09:18,570 --> 00:09:22,950
+lactate to pyruvate وهذا بيزيد من ال hypothesis
+
+113
+00:09:22,950 --> 00:09:29,470
+وبالتالي بيزيد من تكوين ال ketone bodies
+
+114
+00:09:32,160 --> 00:09:36,760
+حسب توصيات الـ American Diabetes Association أنه
+
+115
+00:09:36,760 --> 00:09:43,220
+لازم يكون فيه متابعة للناس اللي عندهم Diabetes
+
+116
+00:09:43,220 --> 00:09:44,900
+وخاصة اللي هو زي ما قلنا الـ Type 1 diabetes
+
+117
+00:09:44,900 --> 00:09:48,820
+mellitus pregnancy with a pre-existing diabetes
+
+118
+00:09:48,820 --> 00:09:52,740
+والنساء اللي عندهم gestational diabetes mellitus
+
+119
+00:09:52,740 --> 00:09:57,500
+لابد أن يكون فيه متابعة للـ ketone bodies في ال
+
+120
+00:09:57,500 --> 00:10:01,570
+urineالشباب اللي بتاعة type 1 diabetes smallitis
+
+121
+00:10:01,570 --> 00:10:04,290
+يجب أن يقوموا بالتجارب لكيتونات في حالة مرضى المرض
+
+122
+00:10:04,290 --> 00:10:08,130
+يبقى لأنه زي ما احنا عارفين في الـ acute illness
+
+123
+00:10:08,130 --> 00:10:17,610
+بيزيد عندنا ممكن بعض الهرمونات اللي بترفع او اللي
+
+124
+00:10:17,610 --> 00:10:22,590
+هي تعتبر تعتبر hyperglycemic hormones وبالتالي
+
+125
+00:10:22,590 --> 00:10:27,130
+ممكن تزيد من تكوين ال ketone bodies يبقى ال
+
+126
+00:10:27,130 --> 00:10:30,400
+patients with type 1 diabetes smallitasلازم برضه
+
+127
+00:10:30,400 --> 00:10:33,840
+يتم فحصهم في ال ketones خلال ال acute illness او
+
+128
+00:10:33,840 --> 00:10:37,260
+stress او with consistent increase in blood
+
+129
+00:10:37,260 --> 00:10:39,740
+glucose اذا كان زاد اننا ال glucose عن تلاتمية
+
+130
+00:10:39,740 --> 00:10:45,160
+milligram per deciliter و برضه خلال اللي هو الحمل
+
+131
+00:10:46,190 --> 00:10:51,850
+أو when symptoms of ketoacidosis are present ومن
+
+132
+00:10:51,850 --> 00:10:54,670
+ال symptoms اللي هي ال ketoacidosis اللي هو في
+
+133
+00:10:54,670 --> 00:10:59,010
+عندنا frequent urination extreme thirst طبعا high
+
+134
+00:10:59,010 --> 00:11:04,470
+اللي هو blood sugar و اللي هو برضه طبعا ارتفاع في
+
+135
+00:11:04,470 --> 00:11:11,940
+ال ketones في ال urineقياس الـ ketones سواء في الـ
+
+136
+00:11:11,940 --> 00:11:15,680
+urine أو البلد widely performed in patients with
+
+137
+00:11:15,680 --> 00:11:21,300
+diabetes سواء للـ diagnosis و أيضًا للـ monitoring
+
+138
+00:11:21,300 --> 00:11:27,400
+زي ما حكينا الآن of diabetic ketoacidosis
+
+139
+00:11:30,120 --> 00:11:32,440
+بالنسبة للجزئية التانية اللي هي ال management
+
+140
+00:11:32,440 --> 00:11:39,520
+للوالي chronic و طبعا من خلال الدراسات المختلفة
+
+141
+00:11:39,520 --> 00:11:47,700
+اللي تمت و اللي ربطت بين مستويات الجلوكوز في الدم
+
+142
+00:11:47,700 --> 00:11:51,520
+و ال development of long term complications of
+
+143
+00:11:51,520 --> 00:11:58,060
+diabetes و عشان هيك لازم يكون فيه أنهمتابعة لمرضى
+
+144
+00:11:58,060 --> 00:12:05,220
+السكري باستمرار والمحافظة على levels من ال glucose
+
+145
+00:12:05,220 --> 00:12:10,640
+اللي تكون يعني إلى حد ما قريبة ممكن من ال
+
+146
+00:12:10,640 --> 00:12:13,640
+reference range أو ممكن تكون أعلى شوية لكن مايكونش
+
+147
+00:12:13,640 --> 00:12:18,990
+في عندنا ارتفاع بشكل كبير في ال glucoseلأنه
+
+148
+00:12:18,990 --> 00:12:24,090
+الارتفاع في ال glucose مرتبط بال complications
+
+149
+00:12:24,090 --> 00:12:30,780
+المختلفة اللي ممكن تصير لمرضى السكريبما يتعلق طبعا
+
+150
+00:12:30,780 --> 00:12:36,400
+بيه ال management ل ال patients فيه على مستوى اللي
+
+151
+00:12:36,400 --> 00:12:39,820
+هو القصير وعلى المستوى البعيد طبعا انه ال .. ال
+
+152
+00:12:39,820 --> 00:12:45,040
+short term ممكن من خلال المستويات لglucose وفي
+
+153
+00:12:45,040 --> 00:12:49,840
+عندنا ال long term monitoring من خلال قياس ال
+
+154
+00:12:49,840 --> 00:12:51,880
+glycated proteins
+
+155
+00:12:53,870 --> 00:12:58,850
+الـ detection and monitoring of complications طبعا
+
+156
+00:12:58,850 --> 00:13:04,350
+بالمختبر احنا ممكن نشوف ال complications اللي
+
+157
+00:13:04,350 --> 00:13:09,610
+متعلقة بال kidney disease وبالـ nephropathy وهذا
+
+158
+00:13:09,610 --> 00:13:12,950
+ممكن بيكون من خلال ال kidney function test زي
+
+159
+00:13:12,950 --> 00:13:19,030
+عندنا ال والكاريتانين وبرضه من خلال ال saying
+
+160
+00:13:19,030 --> 00:13:21,010
+urine for albuminuria
+
+161
+00:13:23,400 --> 00:13:30,480
+برضه في حال انه المريض يعني خضع لبعض العلاجات زي
+
+162
+00:13:30,480 --> 00:13:34,200
+اللي هو الـ Islet Cell أو الـ Pancreas
+
+163
+00:13:34,200 --> 00:13:39,640
+Transplantation في انها انفحوصات بالتم ليه هذا
+
+164
+00:13:39,640 --> 00:13:45,040
+المريض اللي هي الـC-Peptide والإنسلين يعني للتأكد
+
+165
+00:13:45,040 --> 00:13:52,500
+انه هذه الخلايا اللي تم زراعتها يعني تعمل بالشكل
+
+166
+00:13:53,150 --> 00:13:57,950
+المطلوب من
+
+167
+00:13:57,950 --> 00:14:04,610
+الفحوصات اللى بتتملى متابعة مرضى السكري انها زى ما
+
+168
+00:14:04,610 --> 00:14:12,030
+ذكرنا فيه ال glucose ال fasting او ال randomطبعا
+
+169
+00:14:12,030 --> 00:14:15,030
+في ال blood أو في ال urine فينا ال glycated
+
+170
+00:14:15,030 --> 00:14:20,150
+proteins اللي هي ال proteinات اللي ارتبط معها ال
+
+171
+00:14:20,150 --> 00:14:23,570
+glucose يعني ال hemoglobin A1C اللي طبعا الأكثر
+
+172
+00:14:23,570 --> 00:14:29,890
+شهرة فينا fractosamine وفينا أيضا glycated serum
+
+173
+00:14:29,890 --> 00:14:31,070
+albumin
+
+174
+00:14:33,480 --> 00:14:39,260
+يعني انه ايضا one five anhydroglucitol او one five
+
+175
+00:14:39,260 --> 00:14:43,640
+a g فيه برضه ال urinary proteins اللي هو
+
+176
+00:14:43,640 --> 00:14:48,840
+البومنوريا زى ما قولنا لمتابعة اللى هو وضع ال
+
+177
+00:14:48,840 --> 00:14:55,340
+kidney البومنوريا اللى هو الدارج عندنا الاسم او
+
+178
+00:14:55,340 --> 00:15:00,320
+معروف اكتر ب microalbuminuriaلكن الان يعني يفضل
+
+179
+00:15:00,320 --> 00:15:03,720
+انه يتم تسميته بقلبه منه ريا زي ما هنشوف
+
+180
+00:15:03,720 --> 00:15:09,180
+proteinuria ال proteins في ال urine و evaluation
+
+181
+00:15:09,180 --> 00:15:15,620
+of complicationsاللي هو من خلال قياس الـ كريتانين
+
+182
+00:15:15,620 --> 00:15:19,780
+للـ kidney function وعنا الكلسترول و الـ tri
+
+183
+00:15:19,780 --> 00:15:26,100
+-glycerides يعني ممكن عشان نشوف اللي هو ال risk
+
+184
+00:15:26,100 --> 00:15:29,960
+اللي ممكن إصابة بالـ cardiovascular diseases
+
+185
+00:15:29,960 --> 00:15:36,920
+بالنسبة لغلاكات ال proteins أحنا هنحكي عن الـ
+
+186
+00:15:36,920 --> 00:15:42,840
+hemoglobin A1Cإذا حد حابب يحكيلنا عن ال agglicated
+
+187
+00:15:42,840 --> 00:15:46,580
+proteins، يشوف مقالة و يحكي عن ال agglicated
+
+188
+00:15:46,580 --> 00:15:49,320
+proteins بيكون كويسة
+
+189
+00:15:52,910 --> 00:15:55,450
+طبعا من الـ glucated proteins عندنا قلنا الـ
+
+190
+00:15:55,450 --> 00:16:02,390
+hemoglobin A1C هو يعني الأكثر شهرة effective in
+
+191
+00:16:02,390 --> 00:16:07,170
+monitoring long term glucose control in people
+
+192
+00:16:07,170 --> 00:16:11,550
+with diabetes mellitus و دي طبعا من الفحوصات اللي
+
+193
+00:16:11,550 --> 00:16:18,520
+لازم يعني تنعمل كل تلت شهور لمرضى السكريلمعرفة
+
+194
+00:16:18,520 --> 00:16:25,260
+يعني معدل مستوى السكر في التلات شهور السابقة ومدى
+
+195
+00:16:25,260 --> 00:16:30,300
+التزام المريض سواء بالعلاج أو بالحمية
+
+196
+00:16:31,840 --> 00:16:35,800
+يجب من خلال الـ Hemoglobin A1C نحصل على الـ
+
+197
+00:16:35,800 --> 00:16:40,460
+Retrospective Index of Integrated Plasma Glucose
+
+198
+00:16:40,460 --> 00:16:44,220
+Values over an expected period of time، وقولنا هي
+
+199
+00:16:44,220 --> 00:16:50,140
+تقريبًا تلت شهور السابقة Aggregated hemoglobin
+
+200
+00:16:50,140 --> 00:16:54,580
+concentrations therefore are invaluableوقمت بعمل
+
+201
+00:16:54,580 --> 00:16:55,040
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+202
+00:16:55,040 --> 00:16:55,580
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+203
+00:16:55,580 --> 00:16:59,460
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+204
+00:16:59,460 --> 00:17:02,520
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+205
+00:17:02,520 --> 00:17:03,080
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+206
+00:17:03,080 --> 00:17:03,360
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+207
+00:17:03,360 --> 00:17:03,400
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+208
+00:17:03,400 --> 00:17:08,960
+عملية عملية عملية عملية عملية عملية عملية عملية ع
+
+209
+00:17:13,010 --> 00:17:15,510
+أيضًا إجلاكات الهيموجلوبين recently been
+
+210
+00:17:15,510 --> 00:17:19,110
+recommended for the diagnosis of diabetes ويمكن
+
+211
+00:17:19,110 --> 00:17:23,610
+هذا ذكرناه سابقًا لكن زي ما قلنا أنه لازم يكون
+
+212
+00:17:23,610 --> 00:17:27,550
+standardized method اللي تم استخدامها ومش أي طريقة
+
+213
+00:17:28,930 --> 00:17:36,670
+وبرضه مستويات الـ Hemoglobin A1C بتعتبر measure of
+
+214
+00:17:36,670 --> 00:17:39,430
+risk for the development of microvascular
+
+215
+00:17:39,430 --> 00:17:44,910
+complications of diabetes يعني كل ما كان ال
+
+216
+00:17:44,910 --> 00:17:52,030
+Hemoglobin A1C ال percentage أعلى، معناته المريض
+
+217
+00:17:52,030 --> 00:17:56,790
+هذا at higher risk للإصابة بالmicrovascular
+
+218
+00:17:56,790 --> 00:17:57,750
+complications
+
+219
+00:18:00,810 --> 00:18:05,670
+الهيموجلوبين A1C هو المجموعة الكبيرة التي تكون
+
+220
+00:18:05,670 --> 00:18:10,910
+حوالي 80% من الهيموجلوبين A1
+
+221
+00:18:14,630 --> 00:18:20,350
+وعنا الـ Hemoglobin A1 اللي بتكون من Hemoglobin 1A
+
+222
+00:18:20,350 --> 00:18:26,010
+Hemoglobin 1C و Hemoglobin Hemoglobin 1A و
+
+223
+00:18:26,010 --> 00:18:30,650
+Hemoglobin 1B و Hemoglobin 1C تمام؟ فهدول التلاتة
+
+224
+00:18:30,650 --> 00:18:35,570
+بيطلق عليهم Hemoglobin A1 من هدول التلاتة عنا ال
+
+225
+00:18:35,570 --> 00:18:39,790
+major fraction هو ال Hemoglobin A1C و اللي بيمثل
+
+226
+00:18:39,790 --> 00:18:42,010
+80%
+
+227
+00:18:44,730 --> 00:18:48,250
+طبعاً في عندنا برضه يعني أنواع أخرى زي الـ
+
+228
+00:18:48,250 --> 00:18:52,370
+Hemoglobin مثلا A1A اللي هو عبارة عن Hemoglobin A
+
+229
+00:18:52,370 --> 00:18:58,830
+مرتبط مع Fructose Hemoglobin 1A2 اللي هو
+
+230
+00:18:58,830 --> 00:19:03,870
+Hemoglobin A مرتبط مع Glucose 6-Fosfate تمام، يعني
+
+231
+00:19:03,870 --> 00:19:08,030
+في أنواع مختلفة لكن النسبة الأكبر اللي هو الـ
+
+232
+00:19:08,030 --> 00:19:14,500
+Hemoglobin A1C و اللي هي اللي بتتم قياسهاالـ
+
+233
+00:19:14,500 --> 00:19:19,580
+Formation، وطبعاً هذه نقطة مهمة الـ Formation of
+
+234
+00:19:19,580 --> 00:19:23,560
+Glycated Hemoglobin is essentially irreversible
+
+235
+00:19:23,560 --> 00:19:29,500
+وإلا إذا كان reversible يعني مش هيكون دقيق
+
+236
+00:19:29,500 --> 00:19:33,480
+لاستخدامه يبقى الـ Glycated Hemoglobin is
+
+237
+00:19:33,480 --> 00:19:37,560
+essentially irreversible مزال صار فينا ارتباطبين
+
+238
+00:19:37,560 --> 00:19:41,920
+الجلوكوز وبين الـ Hemoglobin يبقى مش هيصير فيه
+
+239
+00:19:41,920 --> 00:19:47,920
+اللي هو effect لجلوكوز مرة أخرى. The concentration
+
+240
+00:19:47,920 --> 00:19:51,500
+in the blood depends on both the lifespan of the
+
+241
+00:19:51,500 --> 00:19:54,880
+red blood cells هذا اللي هو بيعتمد عليه نسبة
+
+242
+00:19:54,880 --> 00:19:59,380
+لجلوكيت ال Hemoglobin اللي هو عمر الخلايا الدم
+
+243
+00:19:59,380 --> 00:20:06,040
+الحمراء وإنالـ Blood Glucose Concentration في
+
+244
+00:20:06,040 --> 00:20:12,480
+الدم، يبقى دول النقطتين اللي بيتمت عليهم نسبة الـ
+
+245
+00:20:12,480 --> 00:20:19,200
+Glucated Hemoglobin في الدم،
+
+246
+00:20:19,200 --> 00:20:22,820
+يبقى عندها الـ Glucose
+
+247
+00:20:25,970 --> 00:20:32,330
+طبعاً بيرتبط على الـ N-terminal amino group لالو
+
+248
+00:20:32,330 --> 00:20:41,250
+ال beta-chain بداية بيكون أن ال الديمين عبارة عن
+
+249
+00:20:41,250 --> 00:20:48,210
+ال skiff baseو بعد هيك ال aldamine هذه بتتحول إلى
+
+250
+00:20:48,210 --> 00:20:54,130
+ketoamine اللي هو ال hemoglobin A1C يبقى بيصير في
+
+251
+00:20:54,130 --> 00:20:59,590
+عنا rearrangement لال aldamine و بيعطيني ketoamine
+
+252
+00:20:59,590 --> 00:21:04,050
+اللي هو ال hemoglobin A1C يبقى ال hemoglobin A مع
+
+253
+00:21:04,050 --> 00:21:10,470
+ال glucose بيعطيني pre hemoglobin A1Cوهذه الخطوة
+
+254
+00:21:10,470 --> 00:21:17,110
+زي ما هو واضحان الخطوة هذه reversible تمام فالخطوة
+
+255
+00:21:17,110 --> 00:21:20,390
+هذه reversible لكن بعد هيك pre-hemoglobin A1C
+
+256
+00:21:20,390 --> 00:21:25,490
+بيصير في أنا rearrangement لهذا المركب تمام
+
+257
+00:21:25,490 --> 00:21:30,790
+وبيعطيني hemoglobin A1C وهذه الخطوة irreversible
+
+258
+00:21:30,790 --> 00:21:34,990
+زي ما احنا شايفين السهم في اتجاه واحد فقط
+
+259
+00:21:37,890 --> 00:21:41,030
+بالنسبة للارتباط اللي بيصير بين الجلوكوز وبين
+
+260
+00:21:41,030 --> 00:21:45,330
+الهيموجلوبين plasma glucose in the preceding one
+
+261
+00:21:45,330 --> 00:21:48,590
+month determines fifty percent of the hemoglobin
+
+262
+00:21:48,590 --> 00:21:53,290
+A1C يعني لو جينا حكينا على تلت شهور ممكن بالشهر
+
+263
+00:21:53,290 --> 00:21:58,110
+الأول بتكون أنه كمية الارتباط قليلة، بالشهر التاني
+
+264
+00:21:58,110 --> 00:22:02,650
+بتزيد و بالشهر التالت بتكون اللي هو أكتر نسبة
+
+265
+00:22:02,650 --> 00:22:05,350
+وبالتالي plasma glucose in the preceding one month
+
+266
+00:22:06,490 --> 00:22:11,890
+الذي يقوم بتحريك 50% من الهيموجلوبين A1C الآن
+
+267
+00:22:11,890 --> 00:22:17,150
+الشهر اللي قبلي بتكون عندى اللي هو نسبة خمسة
+
+268
+00:22:17,150 --> 00:22:22,810
+وعشرين بالمية و اللي هو طبعا الشهر اللي قبل أو
+
+269
+00:22:22,810 --> 00:22:26,170
+الشهرين اللي قبل بتكون عندنا الخمسة وعشرين بالمية
+
+270
+00:22:26,170 --> 00:22:31,850
+اللي ضايلة ال interpretation لليغلاكات
+
+271
+00:22:31,850 --> 00:22:33,910
+الهيموجلوبين depends on red blood cells لأن احنا
+
+272
+00:22:33,910 --> 00:22:39,790
+بنحكي علىالاضطباط لجلوكوز مع الـ Beta-Chain في
+
+273
+00:22:39,790 --> 00:22:41,710
+الهيموجلوبين الموجود في الـ Red Blood Cells
+
+274
+00:22:41,710 --> 00:22:46,230
+وبالتالي أي إشي هيأثر على عمر الـ Red Blood Cells
+
+275
+00:22:46,230 --> 00:22:50,930
+أكيد هيأثر على الـ Negligated Hemoglobin إذا كانت
+
+276
+00:22:50,930 --> 00:22:55,690
+المريض مع مرض هيمولتك أو أشياء أخرى مع تقسيم حياة
+
+277
+00:22:55,690 --> 00:23:01,190
+الـ Red Blood Cells تظهر تقسيم الـ Negligated
+
+278
+00:23:01,190 --> 00:23:05,870
+Hemoglobinبرضه اذا كانت صار فيه انه الوه
+
+279
+00:23:05,870 --> 00:23:10,010
+significant blood loss يبقى individuals with
+
+280
+00:23:10,010 --> 00:23:14,390
+recent significant blood loss برضه هذا ممكن يعطيني
+
+281
+00:23:14,390 --> 00:23:19,250
+الوه falsely low values يبقى ممكن نيجي نفحص و
+
+282
+00:23:19,250 --> 00:23:23,510
+نلاقي انه ال hemoglobin a1c اللي يعني منخفض لكن
+
+283
+00:23:23,510 --> 00:23:27,550
+هذا هكون falsely low لأنه صار في عندي فقط لا كمية
+
+284
+00:23:27,550 --> 00:23:31,370
+يعني كبيرة من الدم
+
+285
+00:23:33,110 --> 00:23:37,230
+واللي هو طبعا الـ high fraction of younger
+
+286
+00:23:37,230 --> 00:23:43,690
+erythrocytes اللي لسه ماصارش فيه ارتباط لجلوكوز
+
+287
+00:23:43,690 --> 00:23:50,050
+بكميات اللي هو يعني كويسة high إجلاكية
+
+288
+00:23:50,050 --> 00:23:53,470
+الهيموجلوبين برضه هذا من ناحية أخرى ممكن يصير فينا
+
+289
+00:23:53,470 --> 00:23:57,570
+ارتفاع لإجلاكية الهيموجلوبين في حالات ال iron
+
+290
+00:23:57,570 --> 00:24:00,930
+deficiency anemiaيبقى في الـ Iron deficiency
+
+291
+00:24:00,930 --> 00:24:03,770
+anemia اللي هي مجلوب ان اذا نسيب اللاجئ انه ال
+
+292
+00:24:03,770 --> 00:24:08,130
+concentration ارتفعت لكن ال mechanism وكيف بيصير
+
+293
+00:24:08,130 --> 00:24:11,050
+هذا الأمر is unknown
+
+294
+00:24:13,780 --> 00:24:17,100
+طبعا زي ما قلنا إنه الـ Hemoglobin A1C أو الـ
+
+295
+00:24:17,100 --> 00:24:21,060
+Glucated Glucated Protein بشكل عام من اللي هي
+
+296
+00:24:21,060 --> 00:24:27,420
+الفحصات اللي بتتم المفروض بشكل دوري و فعليا العديد
+
+297
+00:24:27,420 --> 00:24:32,920
+من المنظمات اللي يعني معنية بهذا المرض و اللي
+
+298
+00:24:32,920 --> 00:24:38,480
+تعتبر مؤثرة برضه اللي هو بتوصي بفحص الـ Hemoglobin
+
+299
+00:24:38,480 --> 00:24:42,060
+A1C اللي هو بشكل روتيني
+
+300
+00:24:43,260 --> 00:24:46,320
+to document degree of glycemic control and to
+
+301
+00:24:46,320 --> 00:24:50,620
+assess response to a treatment عشان نشوف مدى اللي
+
+302
+00:24:50,620 --> 00:24:53,080
+هو الالتزام زي ما حكينا ويديش اللي هو مستويات
+
+303
+00:24:53,080 --> 00:24:59,160
+السكر عند المريض وايضا استجابة المريض للعلاج
+
+304
+00:25:01,150 --> 00:25:04,390
+الـ Absolute risk of retinopathy and nephropathy
+
+305
+00:25:04,390 --> 00:25:07,710
+were directly proportional to the mean hemoglobin
+
+306
+00:25:07,710 --> 00:25:11,270
+A1C concentration عيب جاء من خلال ال hemoglobin
+
+307
+00:25:11,270 --> 00:25:17,770
+A1C برضه ممكن نشوف ال risk للمريض اللي الإصابة بال
+
+308
+00:25:17,770 --> 00:25:21,550
+complications المختلفة و من خلال الدراسات لجوا أنه
+
+309
+00:25:21,550 --> 00:25:25,150
+each one percent reduction in hemoglobin A1C يعني
+
+310
+00:25:25,150 --> 00:25:31,910
+على سبيل المثال كان تمانية و نزلةكان هذا مصاحب لـ
+
+311
+00:25:31,910 --> 00:25:39,290
+reduction of 37% for microvascular disease و أيضًا
+
+312
+00:25:39,290 --> 00:25:44,170
+كان فينا 21% for death related to diabetes كان في
+
+313
+00:25:44,170 --> 00:25:48,810
+انخفاض برضه reduction اللي هو بنسبة 21% و برضه كان
+
+314
+00:25:48,810 --> 00:25:53,860
+في reduction بنسبة 14%للـ myocardial infarction
+
+315
+00:25:53,860 --> 00:26:00,020
+بقى 1% له تأثير كبير في تقريل ال complications
+
+316
+00:26:00,020 --> 00:26:09,040
+المختلفة في أنه طرق عديدة للفحص لجراكات
+
+317
+00:26:09,040 --> 00:26:11,900
+الهيمoglobins ومنها ال hemoglobin A1C more than
+
+318
+00:26:11,900 --> 00:26:18,110
+150 different methods have been describedالـ ADA
+
+319
+00:26:18,110 --> 00:26:21,750
+ترجح بأن البراتبيرات تستخدم فقط الـ Hemoglobin A1c
+
+320
+00:26:21,750 --> 00:26:28,530
+أساسيات تتعامل مع الـ NGSP يقولنا لازم تكون اللي
+
+321
+00:26:28,530 --> 00:26:33,350
+هو standardized with certified method اللي بدنا
+
+322
+00:26:33,350 --> 00:26:40,030
+نستخدمها سواء لل diagnoses أو للمعاملة
+
+323
+00:26:40,030 --> 00:26:41,710
+للطب
+
+324
+00:26:43,870 --> 00:26:50,550
+وفيها على الموقع الأورجينيزييشي الـ NGSB موجود
+
+325
+00:26:50,550 --> 00:26:58,090
+الطرق المعتمدة من قبلهم بالنسبة
+
+326
+00:26:58,090 --> 00:27:01,470
+لنتيجة الـ hemoglobin A1C reported as a percentage
+
+327
+00:27:01,470 --> 00:27:05,690
+وهذا يعني اللي بيستخدم عندنا of total hemoglobin
+
+328
+00:27:07,250 --> 00:27:11,630
+هذا بناءً على الـ NGSP System لكن في عندنا برضه
+
+329
+00:27:11,630 --> 00:27:15,050
+units أخرى ممكن تستخدم اللي هو بناءً على الـ
+
+330
+00:27:15,050 --> 00:27:17,330
+International Federation of Clinical Chemistry
+
+331
+00:27:17,330 --> 00:27:23,990
+وهذه ال units هي ملي مول لكل مول ملي مول
+
+332
+00:27:23,990 --> 00:27:30,010
+Hemoglobin UNC لكل مول من الهمoglobin
+
+333
+00:27:30,010 --> 00:27:35,310
+Multinational
+
+334
+00:27:35,310 --> 00:27:36,650
+Prospective Study
+
+335
+00:27:39,860 --> 00:27:44,500
+وانتجت العلاقة بين مرتبة الهيموغلوبين A1C ومرتبة
+
+336
+00:27:44,500 --> 00:27:49,920
+الهيموغلوبين A1C ومرتبة الهيموغلوبين A1C ومرتبة
+
+337
+00:27:49,920 --> 00:27:58,040
+الهيموغلوبين A1C ومرتبة
+
+338
+00:27:58,040 --> 00:28:06,320
+الهيموغلوبين A1C ومرتبة الهيموغلوبين A1Cوبالتالي
+
+339
+00:28:06,320 --> 00:28:09,060
+ما زال في لينا correlation بيجي ممكن إحنا من خلال
+
+340
+00:28:09,060 --> 00:28:13,760
+ال percentage ل ال hemoglobin A1C ممكن نحدد جداش
+
+341
+00:28:13,760 --> 00:28:19,100
+أو نعمل estimation ل ال average glucose عند هذا
+
+342
+00:28:19,100 --> 00:28:25,300
+المريض و من خلال هذه العلاقة قاملوا اللي هو
+
+343
+00:28:25,300 --> 00:28:30,060
+regression equation اللي
+
+344
+00:28:30,060 --> 00:28:35,610
+هي ال formula عندنا ال estimatedAverage Glucose
+
+345
+00:28:35,610 --> 00:28:41,630
+بالميلي جرام بالديسليتر بتساوي 28.7 ضرب Hemoglobin
+
+346
+00:28:41,630 --> 00:28:47,070
+A1C ناقص 46.7
+
+347
+00:28:48,910 --> 00:28:53,990
+فحص آخر اللي ممكن يستخدم للـ intermediate term
+
+348
+00:28:53,990 --> 00:28:57,770
+احنا شوفنا ان ال glucose لأ ال short term و لأن
+
+349
+00:28:57,770 --> 00:29:01,490
+الجلاجات الهيموجلوبين لأ ال long term و هنا عندنا
+
+350
+00:29:01,490 --> 00:29:08,230
+ال 1,5-anhydroglucitol لأ اللي هو ال intermediate
+
+351
+00:29:08,230 --> 00:29:18,950
+term و من خلال فحصنا لل 1,5-AGممكن هذا يعكس لنا كم
+
+352
+00:29:18,950 --> 00:29:23,730
+كانت الـ Glucose concentration في اليومين إلى 14
+
+353
+00:29:23,730 --> 00:29:33,370
+يوم السابق الـ 15AG هو عبارة عن Deoxy Form of
+
+354
+00:29:33,370 --> 00:29:36,770
+Glucose زي ما هو واضح أنها بيلفجر هيها الجلوكوز
+
+355
+00:29:36,770 --> 00:29:42,490
+تمام بنزع الـ OH group بيحولوا إلى 15
+
+356
+00:29:42,490 --> 00:29:44,410
+-anhydroglicitol
+
+357
+00:29:46,610 --> 00:29:52,490
+من وين بيجي الـ 1,5-anhydroglycitol originates
+
+358
+00:29:52,490 --> 00:29:57,750
+predominantly from the diet يبقى عندنا الكمية
+
+359
+00:29:57,750 --> 00:30:03,170
+الأكبر الأعظم تيجي من ال diet هو أكتر من 99.9%
+
+360
+00:30:06,060 --> 00:30:13,620
+الان الـ 1,5-anhydroglicitol بسلها filtration و
+
+361
+00:30:13,620 --> 00:30:17,120
+بعدين برجع طبعا في ال .. ال kidney و بعدين برجع
+
+362
+00:30:17,120 --> 00:30:24,420
+بسلها reabsorption عن طريق ال SGLT4 اللي هي Sodium
+
+363
+00:30:24,420 --> 00:30:27,040
+Dependent Glucose Transporter
+
+364
+00:30:29,450 --> 00:30:36,210
+في بعض الدراسات اللي .. اللي تمت و اللي استخدموا
+
+365
+00:30:36,210 --> 00:30:42,500
+فيها ال .. ال salivaليه قياس ال one five ag
+
+366
+00:30:42,500 --> 00:30:48,300
+ويلاقوا أنه ممكن فحص ال one five ag في ال saliva
+
+367
+00:30:48,300 --> 00:30:56,120
+ممكن اللي هو يعكس كمية ال one five ag في الدم
+
+368
+00:30:56,120 --> 00:31:01,040
+وبالتالي يعني ممكن فحص ال one five ag في ال saliva
+
+369
+00:31:02,070 --> 00:31:07,630
+يعني أنا ممكن أكون ل اللي هو ال intermediate زي ما
+
+370
+00:31:07,630 --> 00:31:11,650
+قولنا term of monitoring لكن يمكن هذا بيحتاج يعني
+
+371
+00:31:11,650 --> 00:31:14,630
+إلى more research
+
+372
+00:31:18,410 --> 00:31:22,230
+عندما تتجاوز موارد الجلوكوز تتجاوز موارد الرينال
+
+373
+00:31:22,230 --> 00:31:24,850
+تتجاوز موارد الرينال تتجاوز موارد الرينال تتجاوز
+
+374
+00:31:24,850 --> 00:31:31,970
+موارد الرينال تتجاوز موارد الرينال تتجاوز موارد
+
+375
+00:31:31,970 --> 00:31:38,970
+الرينال تتجاوز موارد الرينال تتجاوز موارد الرينال
+
+376
+00:31:38,970 --> 00:31:39,490
+تتجاوز موارد الرينال تتجاوز موارد الرينال تتجاوز
+
+377
+00:31:39,490 --> 00:31:43,810
+موارد الرينال تتجاوز موارد الرينال تتجاوز موارد
+
+378
+00:31:43,810 --> 00:31:50,610
+الرينال تتجاوز موارد الرينال تتجاوز موو هذا بيؤدى
+
+379
+00:31:50,610 --> 00:31:59,450
+الى انخفاض مستوى ال 1,5 Ag في الدم يبقى اذا كان
+
+380
+00:31:59,450 --> 00:32:06,490
+صار في عندي ارتفاع في ال glucose تمام و اتخطى اللى
+
+381
+00:32:06,490 --> 00:32:13,150
+هو حاجز ال 180 معناته هيصير في عنا نقص في ال
+
+382
+00:32:13,150 --> 00:32:18,010
+reabsorption لل 1,5 Agوهذا هيؤدى الى انخفاض الـ 1
+
+383
+00:32:18,010 --> 00:32:25,430
+,5-AG في الدم يبقى بالتالى low 1,5-AG indicates
+
+384
+00:32:25,430 --> 00:32:30,910
+hyperiglycemia إذا انخفض عندنا مستوى الـ 1,5-AG في
+
+385
+00:32:30,910 --> 00:32:34,830
+الدم معناته هذا بيعنى إن هذا الشخص في عنده
+
+386
+00:32:34,830 --> 00:32:39,730
+hyperiglycemia correlated particularly with
+
+387
+00:32:39,730 --> 00:32:44,090
+postprandial blood glucose concentration
+
+388
+00:32:46,800 --> 00:32:53,920
+في جهاز تم عمله لقياس الـ 15AG Automated
+
+389
+00:32:53,920 --> 00:33:00,120
+Calorimetric Assay وهذا الجهاز approved من الـ FDA
+
+390
+00:33:00,120 --> 00:33:07,200
+اللي يسمى الـ glyco mark يمكن من خلاله نشوف اللي
+
+391
+00:33:07,200 --> 00:33:12,380
+هو ال concentration لـ 15الـ AG وبالتالي انحدد
+
+392
+00:33:12,380 --> 00:33:17,280
+اللي هو مستوى الليجلوكوز عند الشخص زي ما قلنا في
+
+393
+00:33:17,280 --> 00:33:24,460
+اليومين إلى أربعة عشر يوم السابقين ومن
+
+394
+00:33:24,460 --> 00:33:32,290
+خلال دراسة و اللي مقارنة مع ال hemoglobin A1Cيعني
+
+395
+00:33:32,290 --> 00:33:38,630
+تبين إن الـ15AG ممكن يكشف عن بعض اللي هو الحالات
+
+396
+00:33:38,630 --> 00:33:48,990
+اللي فعلياً في عندنا يعني ارتفاع في المستوى لـ
+
+397
+00:33:48,990 --> 00:33:53,770
+Glucose اللي هو Spikes يعني من زي ما قلنا
+
+398
+00:33:53,770 --> 00:33:59,950
+الـAposteprandial عادة Spikes من الـHyperglycemia
+
+399
+00:34:01,330 --> 00:34:04,510
+و هنا في عندنا مثال يعني في عندنا هنا patient
+
+400
+00:34:04,510 --> 00:34:12,550
+fifty year old female و ال hemoglobin A1c فحصوه
+
+401
+00:34:12,550 --> 00:34:20,630
+لجوه سبعة point أربعة بالمية و لما فحصو اللي هو ال
+
+402
+00:34:20,630 --> 00:34:24,990
+one five AG لجوه انه ال concentration اتناش point
+
+403
+00:34:24,990 --> 00:34:29,700
+أربعة micro gram لكل milطبعا هنا ان اللي هو ال
+
+404
+00:34:29,700 --> 00:34:33,060
+interpretation ل ال results من عشر الى واحد و
+
+405
+00:34:33,060 --> 00:34:37,620
+تلاتين يعني يعتبر normal احنا قولنا كل ما إذا كان
+
+406
+00:34:37,620 --> 00:34:40,400
+قل طبعا بيكون فينا hyperglycemia أقل من عشر بيكون
+
+407
+00:34:40,400 --> 00:34:44,960
+فينا اللي هو abnormal glycomark
+
+408
+00:34:47,200 --> 00:34:51,840
+يبقى هان صار فيه كمان متابعة للمرضى يعني على كذا
+
+409
+00:34:51,840 --> 00:34:55,980
+يوم و هان زي ما احنا شايفين انه ال spikes لالـ
+
+410
+00:34:55,980 --> 00:35:01,720
+hyperglycemia يعني قليلة و ال hemoglobin A1C 7.4
+
+411
+00:35:01,720 --> 00:35:08,720
+لكن في عندنا patient آخر 49 سنة old male ال
+
+412
+00:35:08,720 --> 00:35:15,490
+hemoglobin A1C برضه 7.4لكن زي ما احنا شايفين انه
+
+413
+00:35:15,490 --> 00:35:22,350
+كان في عنا repeated lengthy spikes في عنا هدول
+
+414
+00:35:22,350 --> 00:35:26,330
+اللي هو ال spikes لو في عنا ارتفاع يعني زي ما
+
+415
+00:35:26,330 --> 00:35:34,090
+شايفين مرات متكررة لجلوكوز تمام زي ما قلنا ان ال
+
+416
+00:35:34,090 --> 00:35:39,290
+hemoglobin A1c 7.4 يعني مشابه لهذه الحالات لإن
+
+417
+00:35:43,270 --> 00:35:50,350
+اللي كشف الارتفاع هذا المتكرر هو ال glucomarg أو
+
+418
+00:35:50,350 --> 00:35:59,660
+ال 15AG بجهان ال 15AG طلع عندنا 4.5 ميكرو جراميعني
+
+419
+00:35:59,660 --> 00:36:06,140
+ممكن يكون يعني مفيد زي ما قولنا بشكل خاص ل .. اللي
+
+420
+00:36:06,140 --> 00:36:14,680
+هو ال intermediate term لمتابعة المرضى انه أيضا من
+
+421
+00:36:14,680 --> 00:36:20,520
+الفحوصات اللي لابد من عملها برضه يعني بشكل روتيني
+
+422
+00:36:20,520 --> 00:36:26,200
+يعني عادة بتنطلب سنويا
+
+423
+00:36:27,790 --> 00:36:33,610
+اللي هو ال albuminuria لأنه طبعا من ال
+
+424
+00:36:33,610 --> 00:36:37,090
+complications أنه ال microvascular complications
+
+425
+00:36:37,090 --> 00:36:43,290
+أنه يصير فيه nephropathy عند ال patients وبالتالي
+
+426
+00:36:43,290 --> 00:36:50,350
+ممكن هذا يؤدي إلى renal damageوالتجارب اللاجئة
+
+427
+00:36:50,350 --> 00:36:51,330
+اللاجئة اللاجئة اللاجئة اللاجئة اللاجئة اللاجئة
+
+428
+00:36:51,330 --> 00:36:53,210
+اللاجئة اللاجئة اللاجئة اللاجئة اللاجئة اللاجئة
+
+429
+00:36:53,210 --> 00:37:01,090
+اللاجئة اللاجئة اللاجئة اللاجئة اللاجئة اللاجئة
+
+430
+00:37:01,090 --> 00:37:06,030
+اللاجئة اللاجئة اللاجئة اللاجئة اللاجئة اللاجئة
+
+431
+00:37:06,030 --> 00:37:11,630
+اللاجئة اللاجئة اللاجئة اللاجئة اللاجئة اللاجئة
+
+432
+00:37:11,630 --> 00:37:20,870
+اللاجئةهم يعني بالاصل كانوا مرضى سكري تقريبا 60%
+
+433
+00:37:20,870 --> 00:37:25,110
+من ال cases اللي هو with end stage renal disease
+
+434
+00:37:25,110 --> 00:37:32,690
+are patients with type 2 diabetes mellitus يبقى
+
+435
+00:37:32,690 --> 00:37:35,070
+most common cause of end stage renal disease in
+
+436
+00:37:35,070 --> 00:37:37,250
+the United States and Europe برضه اللي هو ال
+
+437
+00:37:37,250 --> 00:37:43,370
+diabetesالتأثير على الـ Macroalbuminuria في الـ
+
+438
+00:37:43,370 --> 00:37:50,930
+Type I تم تصفح كـ 15% إلى 25% والتأثير
+
+439
+00:37:50,930 --> 00:37:56,810
+على الـ Macroalbuminuria تم تصفح كـ 25% إلى 40%
+
+440
+00:37:58,880 --> 00:38:06,560
+طبعاً لما بنحكي micro album نوريا نحكي عن ال
+
+441
+00:38:06,560 --> 00:38:13,280
+urinary albumين اللي هو بيتراوح بين تلاتين إلى
+
+442
+00:38:13,280 --> 00:38:18,060
+تلاتمية ملي اجرام فيه اللي هو اربع عشرين hour
+
+443
+00:38:18,060 --> 00:38:23,760
+urine collectionبينما الماكرو ألبوم نوريا مانت و
+
+444
+00:38:23,760 --> 00:38:28,420
+بنحكي عن ال winner album execution اللي هو أكتر من
+
+445
+00:38:28,420 --> 00:38:33,420
+تلاتمية milligram اللي هو في الاربع و عشرين ساعة
+
+446
+00:38:33,420 --> 00:38:40,100
+في ال type one ال type two diabetes malatus برضه
+
+447
+00:38:40,100 --> 00:38:44,160
+microalbum نوريا occurred in 38 percent of
+
+448
+00:38:44,160 --> 00:38:49,350
+participants in a cohort studyيبقى ال type one و
+
+449
+00:38:49,350 --> 00:38:53,730
+ال type two طبعا يعني من ال complications انه يصير
+
+450
+00:38:53,730 --> 00:38:59,170
+في عنا اللي هو micro albumuria و اللي ممكن تتطور
+
+451
+00:38:59,170 --> 00:39:02,090
+ليه برضه macro albumuria
+
+452
+00:39:04,610 --> 00:39:08,370
+التحقق الـ diabetic nephropathy يعتمد على تجارب
+
+453
+00:39:08,370 --> 00:39:10,650
+تجارب ألبومية يتم تجارب ألبومية يتم تجارب ألبومية
+
+454
+00:39:10,650 --> 00:39:13,110
+يتم تجارب ألبومية يتم تجارب ألبومية يتم تجارب
+
+455
+00:39:13,110 --> 00:39:15,890
+ألبومية يتم تجارب ألبومية يتم تجارب ألبومية يتم
+
+456
+00:39:15,890 --> 00:39:19,850
+تجارب ألبومية يتم تجارب ألبومية يتم تجارب ألبومية
+
+457
+00:39:19,850 --> 00:39:20,590
+يتم تجارب ألبومية يتم تجارب ألبومية يتم تجارب
+
+458
+00:39:20,590 --> 00:39:20,630
+ألبومية يتم تجارب ألبومية يتم تجارب ألبومية يتم
+
+459
+00:39:20,630 --> 00:39:21,610
+تجارب ألبومية يتم تجارب ألبومية يتم تجارب ألبومية
+
+460
+00:39:21,610 --> 00:39:25,070
+يتم تجارب ألبومية يتم تجارالـ kidney و بنشوف إذا
+
+461
+00:39:25,070 --> 00:39:31,070
+في عندنا يعني بدأت ال .. ممكن ال nephropathy أو
+
+462
+00:39:31,070 --> 00:39:35,730
+بدأ يصير في عندنا خلل في ال kidney Persistent
+
+463
+00:39:35,730 --> 00:39:38,930
+proteinuria detectable by routine screening
+
+464
+00:39:43,120 --> 00:39:46,260
+الـ Persistent اللي هو proteinuria أو اللي هو
+
+465
+00:39:46,260 --> 00:39:49,640
+سبناها ال macro proteinuria detectable by routine
+
+466
+00:39:49,640 --> 00:39:54,020
+screening test الألبومين اللي هو execution rate
+
+467
+00:39:54,020 --> 00:39:57,360
+أكتر من 200 ميكرو جرام لكل minute أو اللي هو أكتر
+
+468
+00:39:57,360 --> 00:40:03,900
+من 300 ميلي جرام زي ما حكينا في ال 24 hours طبعا
+
+469
+00:40:03,900 --> 00:40:06,660
+إذا كان في عندنا persistent proteinuria أو اللي هو
+
+470
+00:40:06,660 --> 00:40:12,620
+macroاللي هو ألبوم نوريا معناته هذا بيوحي أنه
+
+471
+00:40:12,620 --> 00:40:15,820
+فيانا overt diabetic nephropathy
+
+472
+00:40:18,000 --> 00:40:20,720
+طبعا هذا يعني من ال .. أكيد اللي هو الـ long term
+
+473
+00:40:20,720 --> 00:40:24,300
+complications associated with long standing
+
+474
+00:40:24,300 --> 00:40:29,220
+disease. Once diabetic nephropathy occurs, renal
+
+475
+00:40:29,220 --> 00:40:33,260
+function deteriorates rapidly and renal
+
+476
+00:40:33,260 --> 00:40:38,220
+insufficiency evolves وطبعا ممكن ينتهي المريض بيه
+
+477
+00:40:38,220 --> 00:40:42,040
+اللي هو end stage renal disease و renal failure
+
+478
+00:40:42,920 --> 00:40:46,360
+Treatment at this stage can retard the rate of
+
+479
+00:40:46,360 --> 00:40:50,240
+percolation without stopping or reversing the
+
+480
+00:40:50,240 --> 00:40:56,320
+renal damage عشان
+
+481
+00:40:56,320 --> 00:41:05,020
+هيك طبعا لي المتابعة مهمةيعني أنه نكشف عن وجود ال
+
+482
+00:41:05,020 --> 00:41:08,000
+.. ال .. ال album نوريا أو زي ما قلنا كانت يعني
+
+483
+00:41:08,000 --> 00:41:12,460
+تسمى سابق ال micro album نوريا وبالتالي يعني ممكن
+
+484
+00:41:12,460 --> 00:41:18,520
+يكون فيه فرصة للتدخل ومنع حدوث ال .. ال renal
+
+485
+00:41:18,520 --> 00:41:19,640
+failure
+
+486
+00:41:22,040 --> 00:41:24,860
+يبقى preceding this stage اللي جاب لمرحلة الـ
+
+487
+00:41:24,860 --> 00:41:28,200
+Macroalbuminuria فيه أنه مرحلة of increased
+
+488
+00:41:28,200 --> 00:41:32,720
+albumin execution rate not detected by routine
+
+489
+00:41:32,720 --> 00:41:36,720
+dipstick methods يبقى بالطريقة اللي هو العادية
+
+490
+00:41:36,720 --> 00:41:40,560
+اللي بنفحص فيها ال protein و ال dipstick مش ممكن
+
+491
+00:41:40,560 --> 00:41:45,140
+أنه نقدر نعمل detection لهذه الكميات القليلة من
+
+492
+00:41:45,530 --> 00:41:48,430
+الألبوم اللي يتراوح بين عشرين إلى متين microgram
+
+493
+00:41:48,430 --> 00:41:52,270
+في ال minute أو تلاتين إلى تلاتمائة milligram لكل
+
+494
+00:41:52,270 --> 00:41:57,090
+اللي هو أربع وعشرين ساعة تمام و هذه المرحلة اللي
+
+495
+00:41:57,090 --> 00:42:02,610
+قلنا microalbuminuria أو albuminuria current
+
+496
+00:42:02,610 --> 00:42:04,490
+nomenclature has eliminated the term
+
+497
+00:42:04,490 --> 00:42:09,750
+microalbuminuriaان macro albumuria يعني الآن لأنه
+
+498
+00:42:09,750 --> 00:42:14,610
+يعني ممكن تفهم خطأ اللي هي micro albumuria تمام
+
+499
+00:42:14,610 --> 00:42:17,330
+انه بنحكي يعني عن album اللي هو ممكن يكون يعني
+
+500
+00:42:17,330 --> 00:42:22,790
+micro او يعني صغير واستبدلوه بال albumuria لكن
+
+501
+00:42:22,790 --> 00:42:26,110
+لغاية الآن يعني ناس كتير بتستخدم اللي هو ال micro
+
+502
+00:42:26,110 --> 00:42:29,010
+albumuria و ال macro albumuria
+
+503
+00:42:31,210 --> 00:42:33,510
+تمام يبقى السبب زي ما قلنا ان ال macro albumuria
+
+504
+00:42:33,510 --> 00:42:37,850
+يعني ممكن يكون misleading اه يعني ما يتبش فاهم
+
+505
+00:42:37,850 --> 00:42:42,310
+المصطلح بشكل الصحيح implies a small version of the
+
+506
+00:42:42,310 --> 00:42:45,970
+album molecule rather than an excretion rate of
+
+507
+00:42:45,970 --> 00:42:49,590
+album greater than normal but less than detectable
+
+508
+00:42:49,590 --> 00:42:53,570
+by routine methods يبقى ممكن نفهم ان micro معناته
+
+509
+00:42:53,570 --> 00:42:57,910
+ان في عندنا يعني زي نسخة لكن اللي هي أصغر ممكن من
+
+510
+00:42:57,910 --> 00:43:03,180
+ال album الطبيعيوبتاع علشان هيك اللي هو ال micro
+
+511
+00:43:03,180 --> 00:43:07,240
+albumuria يعني لا يحبة استخدام هذا المصطرح لكن
+
+512
+00:43:07,240 --> 00:43:12,180
+احنا الدارج اللي اللي فعليا بيستخدم هو ال micro
+
+513
+00:43:12,180 --> 00:43:18,020
+albumuria طبعا
+
+514
+00:43:18,020 --> 00:43:27,180
+المشكلة هان انه بيصير في عندنا مرور لال album عبر
+
+515
+00:43:28,810 --> 00:43:32,310
+الـ glomerulus هالي عبارة عن tuft of capillaries
+
+516
+00:43:32,310 --> 00:43:35,830
+زي ما انتوا عارفين و اللي من خلالها بيصير عملية ال
+
+517
+00:43:35,830 --> 00:43:44,710
+wall filtration لل blood و في عندنا طبعا يعني اللي
+
+518
+00:43:44,710 --> 00:43:51,610
+هي ال proteinات اللي molecular weight أقل
+
+519
+00:43:51,610 --> 00:43:51,890
+من
+
+520
+00:43:54,810 --> 00:44:01,290
+تقريبا ستين كيلو تلتن، يبقى ال .. إذا كان أكبر من
+
+521
+00:44:01,290 --> 00:44:05,430
+ستين كيلو تلتن يبقى بيسلهوش فيلتريش يفضل موجود
+
+522
+00:44:05,430 --> 00:44:09,050
+بالدم، إذا أقل ممكن يسلهو filtration، الآن بيصير
+
+523
+00:44:09,050 --> 00:44:15,290
+فينا مشكلةفي ال ال pores الموجودة في ال
+
+524
+00:44:15,290 --> 00:44:21,790
+capillaries وبالتالي هذا بيسمح بمرور اللي هو
+
+525
+00:44:21,790 --> 00:44:26,290
+proteins اللي ال molecular weight بتاعتها أكبر من
+
+526
+00:44:26,290 --> 00:44:31,310
+ستين kilo Dalton اللي هو زي ال album و بالتالي
+
+527
+00:44:31,310 --> 00:44:37,710
+بنلاقي أنه بدأ يصير فينا concentration أعلى من هذه
+
+528
+00:44:37,710 --> 00:44:44,590
+ال proteins في ال urineيبقى متابعتنا لكميات
+
+529
+00:44:44,590 --> 00:44:49,610
+الألبومين اللي بتسلق execution في ال urine بتعطي
+
+530
+00:44:49,610 --> 00:44:55,070
+indication عن حالةالـ microvessels في الكدن
+
+531
+00:44:55,070 --> 00:45:00,130
+وبالتالي الـ risk للإصابة بالـ diabetic
+
+532
+00:45:00,130 --> 00:45:04,310
+nephropathy أو يعني مستقبلا بالـ end-stage renal
+
+533
+00:45:04,310 --> 00:45:08,250
+disease يبقى persistent album in execution rate
+
+534
+00:45:08,250 --> 00:45:12,410
+greater than 20 microgram per minute represents a
+
+535
+00:45:12,410 --> 00:45:16,330
+twenty-fold greater risk for the development of
+
+536
+00:45:16,330 --> 00:45:22,260
+clinically overt renal diseaseوإذا كان إن الـ
+
+537
+00:45:22,260 --> 00:45:25,920
+execution أعلى من عشرين microgram بالدقيقة، يبقى
+
+538
+00:45:25,920 --> 00:45:31,780
+معناته الشخص هذا عنده ال risk عشرين مرة أكتر
+
+539
+00:45:31,780 --> 00:45:36,880
+للإصابة بالـ kidney disease و بال patients في
+
+540
+00:45:36,880 --> 00:45:44,460
+الtype 1 أو الtype 2وبرضه العديد من الدراسات أكدت
+
+541
+00:45:44,460 --> 00:45:48,240
+هذا الكلام وأكدت إن الـ Increased urinary album
+
+542
+00:45:48,240 --> 00:45:50,840
+execution in patients with diabetes mellitus
+
+543
+00:45:50,840 --> 00:45:54,060
+precedes and is highly predictive of diabetic
+
+544
+00:45:54,060 --> 00:45:56,800
+nephropathy, end-stage renal disease,
+
+545
+00:45:57,400 --> 00:46:02,280
+cardiovascular mortality و الـ total mortality
+
+546
+00:46:02,280 --> 00:46:03,580
+بشكل عام
+
+547
+00:46:06,170 --> 00:46:13,290
+والبتابعة مهمة لأنه فعليًا إذا كان تم الكشف
+
+548
+00:46:13,290 --> 00:46:22,650
+عن الـ Albuminuria يبقى التدخل العلاجي ممكن يقلل
+
+549
+00:46:22,650 --> 00:46:26,730
+من احتمالية إصابة الشخص مستقبلا بـ Kidney Disease
+
+550
+00:46:26,730 --> 00:46:33,750
+وهذا من خلال دراستيناللي هو باسمها DCCT و UKPDS
+
+551
+00:46:33,750 --> 00:46:37,910
+هدول الدراستين لاجوا إنه intensive diabetes
+
+552
+00:46:37,910 --> 00:46:41,470
+therapy can significantly reduce the risk of
+
+553
+00:46:41,470 --> 00:46:45,230
+development of increased albumin excretion rate
+
+554
+00:46:45,230 --> 00:46:48,290
+and overt nephropathy in individuals with diabetes
+
+555
+00:46:48,290 --> 00:46:58,730
+يبقى التدخل ممكن فعليًا يقلل من اللي هو يعنيالـ
+
+556
+00:46:58,730 --> 00:47:03,910
+Nephropathy أو الإصابة بالـ Renal Disease يعشان
+
+557
+00:47:03,910 --> 00:47:09,810
+هيك المتابعة لمستويات ال album بال urine مهمة
+
+558
+00:47:12,210 --> 00:47:17,870
+برضه اللي هو الزيادة في ال execution لـ ال albumin
+
+559
+00:47:17,870 --> 00:47:24,850
+بالـ urine برضه مرتبط بالـ cardiovascular diseases
+
+560
+00:47:24,850 --> 00:47:28,770
+برضه و زيادة في ال albumin execution rate
+
+561
+00:47:28,770 --> 00:47:32,950
+identifies a group of non-diabetic subjects at
+
+562
+00:47:32,950 --> 00:47:39,830
+increased risk for coronary artery disease وكمان
+
+563
+00:47:39,830 --> 00:47:44,050
+حتى عنداللي هو الناس ممكن اللي مش مصابين
+
+564
+00:47:44,050 --> 00:47:52,570
+بالديابتاس ممكن استخدام هذا الفحص لمعرفة خطر
+
+565
+00:47:52,570 --> 00:47:57,110
+إصابتهم بالـ Coronary Artery Disease من الـ
+
+566
+00:47:57,110 --> 00:47:59,930
+interventions ال control of blood glucose
+
+567
+00:47:59,930 --> 00:48:05,250
+concentration و blood pressure particularly with
+
+568
+00:48:05,250 --> 00:48:09,860
+angiotensin converting enzyme inhibitorsعشان اللي
+
+569
+00:48:09,860 --> 00:48:15,660
+هي من مخفضة طبعا أدوية المخفضة ليه الضغط Slow the
+
+570
+00:48:15,660 --> 00:48:22,580
+rate of decline in renal function وهنا
+
+571
+00:48:22,580 --> 00:48:25,920
+اللي هو نتائج الدراستين اللي حكينا عليهم اللي هو
+
+572
+00:48:25,920 --> 00:48:31,720
+ال DCCT و ال UKBDS و في دراسة أخرى أيضا Komamoto
+
+573
+00:48:33,340 --> 00:48:36,500
+التخفيض الـ hemoglobin A1C يعني هان في هذه الدراسة
+
+574
+00:48:36,500 --> 00:48:40,840
+الأولى من 9 على 7.2 قلل ال incidence of
+
+575
+00:48:40,840 --> 00:48:44,180
+complications للـ retinopathy بنسبة 63% نفروباثي
+
+576
+00:48:44,180 --> 00:48:48,740
+بنسبة 54% نيوروباثي بنسبة 60% و ال cardiovascular
+
+577
+00:48:48,740 --> 00:48:54,380
+disease بنسبة 41% دراسة تانية قللوا ال hemoglobin
+
+578
+00:48:54,380 --> 00:48:58,520
+A1C من 9 إلى 7 برضه هذا قلل من ال complications
+
+579
+00:48:58,520 --> 00:49:04,700
+بالرتينوباثي و النفروباثي و أيضا حسنمن اللي هو
+
+580
+00:49:04,700 --> 00:49:11,940
+يعني عمل اللي هو الأعصاب أو ال neurons و الدراسة
+
+581
+00:49:11,940 --> 00:49:16,820
+التالتة قللوا ال hemoglobin ONC من تمانية إلى سبعة
+
+582
+00:49:16,820 --> 00:49:21,940
+وهذا برضه قلل من ال incidence ل ال complications
+
+583
+00:49:21,940 --> 00:49:25,680
+زي الwaritinopathy و ال nephropathy و أيضا ال
+
+584
+00:49:25,680 --> 00:49:28,440
+cardiovascular disease
+
+585
+00:49:31,150 --> 00:49:34,870
+هيك منكن ان نتهينا من اللي هي محاضرة ال debitas
+
+586
+00:49:34,870 --> 00:49:39,710
+maletas الجزئين و بيضل عندنا ال case studies اللي
+
+587
+00:49:39,710 --> 00:49:46,350
+هنشوف ان شاء الله في اللقاء الوجاهي و يعطيكوا الف
+
+588
+00:49:46,350 --> 00:49:46,910
+عافية
+
diff --git a/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/wr_r91FrC-Q_raw.json b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/wr_r91FrC-Q_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..5d11291a88b6141a8e203bfea74b1e2c2ec5b3d1
--- /dev/null
+++ b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/wr_r91FrC-Q_raw.json
@@ -0,0 +1 @@
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"text": "لكن الان يعني يفضل انه يتم تسميته بقلبه منه ريا زي ما هنشوف proteinuria ال proteins في ال urine و evaluation of complications", "tokens": [1211, 19452, 2423, 7649, 37495, 22653, 7251, 5172, 11242, 1211, 16472, 3224, 7251, 39237, 6055, 38251, 36081, 3224, 4724, 4587, 46152, 3224, 9154, 3224, 12602, 25528, 30767, 1829, 19446, 8032, 1863, 8592, 38688, 7944, 37299, 2423, 15577, 8978, 2423, 27638, 4032, 13344, 295, 26566], "avg_logprob": -0.23489583333333333, "compression_ratio": 1.3065693430656935, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 898.68, "end": 899.14, "word": "لكن", "probability": 0.803466796875}, {"start": 899.14, "end": 899.44, "word": " الان", "probability": 0.5626220703125}, {"start": 899.44, "end": 899.62, "word": " يعني", "probability": 0.937255859375}, {"start": 899.62, "end": 900.32, "word": " يفضل", "probability": 0.9891357421875}, {"start": 900.32, "end": 901.16, "word": " انه", "probability": 0.839111328125}, {"start": 901.16, "end": 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monitoring long term glucose control in people with diabetes mellitus و دي طبعا من الفحوصات اللي لازم يعني تنعمل كل تلت شهور لمرضى السكري", "tokens": [9566, 3555, 3615, 995, 9154, 2423, 39184, 1563, 1311, 770, 15577, 43242, 8315, 12174, 1211, 8315, 2423, 39184, 8636, 45841, 13496, 316, 16, 34, 31439, 37495, 22653, 16247, 4117, 49115, 13412, 3224, 25720, 4942, 294, 11028, 938, 1433, 23997, 1969, 294, 561, 365, 13881, 385, 285, 30973, 4032, 11778, 1829, 23032, 3555, 3615, 995, 9154, 27188, 5016, 2407, 9381, 9307, 13672, 1829, 5296, 31377, 2304, 37495, 22653, 6055, 1863, 25957, 1211, 28242, 6055, 1211, 2655, 13412, 3224, 13063, 32767, 43042, 7578, 21136, 4117, 16572], "avg_logprob": -0.18676470027250403, "compression_ratio": 1.3896103896103895, "no_speech_prob": 0.0, "words": [{"start": 952.91, "end": 953.23, "word": "طبعا", "probability": 0.946533203125}, {"start": 953.23, "end": 953.41, "word": " من", "probability": 0.931640625}, {"start": 953.41, "end": 953.69, "word": " الـ", 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"start": 1080.81, "end": 1090.91, "text": "الهيموجلوبين A1C هو المجموعة الكبيرة التي تكون حوالي 80% من الهيموجلوبين A1", "tokens": [6027, 3224, 32640, 29245, 1211, 37746, 9957, 316, 16, 34, 31439, 9673, 7435, 2304, 45367, 3660, 33251, 3555, 48923, 38392, 6055, 30544, 11331, 2407, 6027, 1829, 4688, 4, 9154, 2423, 3224, 32640, 29245, 1211, 37746, 9957, 316, 16], "avg_logprob": -0.49078527169349867, "compression_ratio": 1.4395604395604396, "no_speech_prob": 0.0, "words": [{"start": 1080.81, "end": 1081.59, "word": "الهيموجلوبين", "probability": 0.6636090959821429}, {"start": 1081.59, "end": 1082.09, "word": " A1C", "probability": 0.83935546875}, {"start": 1082.09, "end": 1082.41, "word": " هو", "probability": 0.325927734375}, {"start": 1082.41, "end": 1083.93, "word": " المجموعة", "probability": 0.52265625}, {"start": 1083.93, "end": 1083.93, "word": " الكبيرة", "probability": 0.4783528645833333}, {"start": 1083.93, "end": 1085.11, "word": " التي", "probability": 0.315673828125}, 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{"start": 1111.91, "end": 1112.91, "word": " A1", "probability": 0.973876953125}, {"start": 1112.91, "end": 1113.87, "word": " من", "probability": 0.95166015625}, {"start": 1113.87, "end": 1114.17, "word": " هدول", "probability": 0.9851888020833334}, {"start": 1114.17, "end": 1114.99, "word": " التلاتة", "probability": 0.9886474609375}, {"start": 1114.99, "end": 1115.41, "word": " عنا", "probability": 0.81787109375}, {"start": 1115.41, "end": 1115.57, "word": " ال", "probability": 0.873046875}, {"start": 1115.57, "end": 1115.83, "word": " major", "probability": 0.73876953125}, {"start": 1115.83, "end": 1116.43, "word": " fraction", "probability": 0.8701171875}, {"start": 1116.43, "end": 1116.65, "word": " هو", "probability": 0.90185546875}, {"start": 1116.65, "end": 1116.81, "word": " ال", "probability": 0.65234375}, {"start": 1116.81, "end": 1117.65, "word": " Hemoglobin", "probability": 0.8857421875}, {"start": 1117.65, "end": 1118.93, "word": " A1C", "probability": 0.962890625}, 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"temperature": 1.0}, {"id": 53, "seek": 117652, "start": 1153.96, "end": 1176.52, "text": "الـ Formation، وطبعاً هذه نقطة مهمة الـ Formation of Glycated Hemoglobin is essentially irreversible وإلا إذا كان reversible يعني مش هيكون دقيق لاستخدامه يبقى الـ Glycated Hemoglobin is essentially irreversible مزال صار فينا ارتباط", "tokens": [6027, 39184, 10126, 399, 12399, 4032, 9566, 3555, 3615, 995, 14111, 29538, 8717, 47432, 3660, 3714, 16095, 3660, 2423, 39184, 10126, 399, 295, 460, 356, 66, 770, 18568, 45841, 13496, 307, 4476, 16014, 840, 964, 4032, 28814, 15040, 11933, 15730, 25961, 44788, 37495, 22653, 37893, 39896, 30544, 11778, 38436, 4587, 20193, 14851, 9778, 3215, 10943, 3224, 7251, 3555, 4587, 7578, 2423, 39184, 460, 356, 66, 770, 18568, 45841, 13496, 307, 4476, 16014, 840, 964, 3714, 11622, 6027, 20328, 9640, 8978, 8315, 1975, 43500, 3555, 41193], "avg_logprob": -0.18786337746437207, "compression_ratio": 1.565, "no_speech_prob": 8.344650268554688e-07, "words": [{"start": 1153.96, 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الجلوكوز وبين الـ Hemoglobin يبقى مش هيصير فيه اللي هو effect لجلوكوز مرة أخرى. The concentration in the blood depends on both the lifespan of the red blood cells هذا اللي هو بيعتمد عليه نسبة لجلوكيت ال Hemoglobin اللي هو عمر الخلايا الدم الحمراء وإن", "tokens": [3555, 9957, 25724, 1211, 2407, 4117, 2407, 11622, 46599, 9957, 2423, 39184, 18568, 45841, 13496, 7251, 3555, 4587, 7578, 37893, 39896, 9381, 13546, 8978, 3224, 13672, 1829, 31439, 1802, 5296, 7435, 1211, 2407, 4117, 2407, 11622, 3714, 25720, 5551, 34740, 7578, 13, 440, 9856, 294, 264, 3390, 5946, 322, 1293, 264, 40361, 295, 264, 2182, 3390, 5438, 23758, 13672, 1829, 31439, 4724, 1829, 34268, 2304, 3215, 47356, 8717, 35457, 3660, 5296, 7435, 1211, 2407, 4117, 36081, 2423, 18568, 45841, 13496, 13672, 1829, 31439, 6225, 29973, 33962, 15040, 25528, 32748, 2304, 21542, 29973, 16606, 4032, 28814, 1863], "avg_logprob": -0.1997422729570841, "compression_ratio": 1.5862068965517242, "no_speech_prob": 2.384185791015625e-07, "words": [{"start": 1177.18, "end": 1177.56, "word": "بين", "probability": 0.821533203125}, 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"probability": 0.8194173177083334}, {"start": 1219.2, "end": 1221.6, "word": " يبقى", "probability": 0.9791259765625}, {"start": 1221.6, "end": 1221.98, "word": " عندها", "probability": 0.66162109375}, {"start": 1221.98, "end": 1222.22, "word": " الـ", "probability": 0.646240234375}, {"start": 1222.22, "end": 1222.82, "word": " Glucose", "probability": 0.9020182291666666}], "temperature": 1.0}, {"id": 56, "seek": 124231, "start": 1225.97, "end": 1242.31, "text": "طبعاً بيرتبط على الـ N-terminal amino group لالو ال beta-chain بداية بيكون أن ال الديمين عبارة عن ال skiff base", "tokens": [9566, 3555, 3615, 995, 14111, 4724, 13546, 2655, 3555, 9566, 15844, 2423, 39184, 426, 12, 7039, 2071, 24674, 1594, 5296, 6027, 2407, 2423, 9861, 12, 11509, 4724, 28259, 10632, 4724, 1829, 30544, 14739, 2423, 2423, 16254, 2304, 9957, 6225, 3555, 9640, 3660, 18871, 2423, 1110, 3661, 3096], "avg_logprob": -0.43001301152010757, "compression_ratio": 1.2148148148148148, "no_speech_prob": 0.0, "words": 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الهيموجلوبين plasma glucose in the preceding one month determines fifty percent of the hemoglobin A1C يعني لو جينا حكينا على تلت شهور ممكن بالشهر الأول بتكون أنه كمية الارتباط قليلة، بالشهر التاني بتزيد و بالشهر التالت بتكون اللي هو أكتر نسبة وبالتالي plasma glucose in the preceding one month", "tokens": [3555, 6027, 1863, 35457, 3660, 24976, 9640, 2655, 3555, 41193, 13672, 1829, 4724, 1829, 9381, 13546, 49374, 25724, 1211, 2407, 4117, 2407, 11622, 46599, 9957, 2423, 3224, 32640, 29245, 1211, 37746, 9957, 22564, 23997, 294, 264, 16969, 278, 472, 1618, 24799, 13442, 3043, 295, 264, 8636, 45841, 13496, 316, 16, 34, 37495, 22653, 45164, 10874, 1829, 8315, 11331, 4117, 1829, 8315, 15844, 6055, 1211, 2655, 13412, 3224, 13063, 3714, 43020, 20666, 8592, 3224, 2288, 16247, 12610, 39894, 30544, 14739, 3224, 9122, 2304, 10632, 2423, 9640, 2655, 3555, 41193, 12174, 20292, 37977, 12399, 20666, 8592, 3224, 2288, 16712, 7649, 1829, 39894, 11622, 25708, 4032, 20666, 8592, 3224, 2288, 16712, 6027, 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تكون", "probability": 0.971923828125}, {"start": 1587.79, "end": 1588.53, "word": " اللي", "probability": 0.515289306640625}, {"start": 1588.53, "end": 1588.67, "word": " هو", "probability": 0.80224609375}, {"start": 1588.67, "end": 1589.63, "word": " standardized", "probability": 0.496826171875}, {"start": 1589.63, "end": 1590.25, "word": " with", "probability": 0.72998046875}, {"start": 1590.25, "end": 1591.07, "word": " certified", "probability": 0.78173828125}, {"start": 1591.07, "end": 1592.01, "word": " method", "probability": 0.97314453125}, {"start": 1592.01, "end": 1593.07, "word": " اللي", "probability": 0.9609375}, {"start": 1593.07, "end": 1593.35, "word": " بدنا", "probability": 0.96240234375}, {"start": 1593.35, "end": 1594.13, "word": " نستخدمها", "probability": 0.9888671875}, {"start": 1594.13, "end": 1594.55, "word": " سواء", "probability": 0.92919921875}, {"start": 1594.55, "end": 1594.85, "word": " لل", "probability": 0.68798828125}, {"start": 1594.85, "end": 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4724, 1829, 14851, 9778, 40448, 43242, 8315, 295, 3217, 8636, 45841, 13496], "avg_logprob": -0.2146381590711443, "compression_ratio": 1.37, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1603.87, "end": 1604.37, "word": "وفيها", "probability": 0.7027994791666666}, {"start": 1604.37, "end": 1604.79, "word": " على", "probability": 0.66943359375}, {"start": 1604.79, "end": 1605.55, "word": " الموقع", "probability": 0.9576822916666666}, {"start": 1605.55, "end": 1606.69, "word": " الأورجينيزييشي", "probability": 0.723486328125}, {"start": 1606.69, "end": 1606.81, "word": " الـ", "probability": 0.418701171875}, {"start": 1606.81, "end": 1609.11, "word": " NGSB", "probability": 0.8121744791666666}, {"start": 1609.11, "end": 1610.55, "word": " موجود", "probability": 0.9178059895833334}, {"start": 1610.55, "end": 1611.37, "word": " الطرق", "probability": 0.8689778645833334}, {"start": 1611.37, "end": 1612.99, "word": " المعتمدة", "probability": 0.98046875}, {"start": 1612.99, 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"probability": 0.91357421875}, {"start": 1634.51, "end": 1634.69, "word": " على", "probability": 0.89990234375}, {"start": 1634.69, "end": 1635.05, "word": " الـ", "probability": 0.6785888671875}, {"start": 1635.05, "end": 1635.51, "word": " International", "probability": 0.77587890625}, {"start": 1635.51, "end": 1636.17, "word": " Federation", "probability": 0.943359375}, {"start": 1636.17, "end": 1636.31, "word": " of", "probability": 0.9169921875}, {"start": 1636.31, "end": 1636.67, "word": " Clinical", "probability": 0.91552734375}, {"start": 1636.67, "end": 1637.33, "word": " Chemistry", "probability": 0.935546875}, {"start": 1637.33, "end": 1639.29, "word": " وهذه", "probability": 0.739990234375}, {"start": 1639.29, "end": 1639.49, "word": " ال", "probability": 0.9794921875}, {"start": 1639.49, "end": 1639.73, "word": " units", "probability": 0.92041015625}, {"start": 1639.73, "end": 1640.05, "word": " هي", "probability": 0.89892578125}, {"start": 1640.05, "end": 1640.53, "word": " ملي", "probability": 0.48199462890625}, {"start": 1640.53, "end": 1641.41, "word": " مول", "probability": 0.88916015625}, {"start": 1641.41, "end": 1642.17, "word": " لكل", "probability": 0.976806640625}, {"start": 1642.17, "end": 1642.73, "word": " مول", "probability": 0.963134765625}, {"start": 1642.73, "end": 1643.75, "word": " ملي", "probability": 0.588134765625}, {"start": 1643.75, "end": 1643.99, "word": " مول", "probability": 0.97216796875}, {"start": 1643.99, "end": 1644.45, "word": " Hemoglobin", "probability": 0.7392578125}, {"start": 1644.45, "end": 1644.77, "word": " UNC", "probability": 0.2088623046875}, {"start": 1644.77, "end": 1645.49, "word": " لكل", "probability": 0.970703125}, {"start": 1645.49, "end": 1648.47, "word": " مول", "probability": 0.871826171875}, {"start": 1648.47, "end": 1648.81, "word": " من", "probability": 0.96630859375}, {"start": 1648.81, "end": 1650.01, "word": " الهمoglobin", "probability": 0.78863525390625}, {"start": 1650.01, "end": 1655.31, "word": " Multinational", "probability": 0.6701253255208334}, {"start": 1655.31, "end": 1656.25, "word": " Prospective", "probability": 0.767333984375}, {"start": 1656.25, "end": 1656.65, "word": " Study", "probability": 0.9345703125}], "temperature": 1.0}, {"id": 73, "seek": 168346, "start": 1659.86, "end": 1683.46, "text": "وانتجت العلاقة بين مرتبة الهيموغلوبين A1C ومرتبة الهيموغلوبين A1C ومرتبة الهيموغلوبين A1C ومرتبة الهيموغلوبين A1C ومرتبة الهيموغلوبين A1C ومرتبة الهيموغلوبين A1C", "tokens": [2407, 7649, 2655, 7435, 2655, 18863, 15040, 28671, 49374, 3714, 43500, 49401, 2423, 3224, 32640, 2407, 17082, 1211, 37746, 9957, 316, 16, 34, 4032, 2304, 43500, 49401, 2423, 3224, 32640, 2407, 17082, 1211, 37746, 9957, 316, 16, 34, 4032, 2304, 43500, 49401, 2423, 3224, 32640, 2407, 17082, 1211, 37746, 9957, 316, 16, 34, 4032, 2304, 43500, 49401, 2423, 3224, 32640, 2407, 17082, 1211, 37746, 9957, 316, 16, 34, 4032, 2304, 43500, 49401, 2423, 3224, 32640, 2407, 17082, 1211, 37746, 9957, 316, 16, 34, 4032, 2304, 43500, 49401, 2423, 3224, 32640, 2407, 17082, 1211, 37746, 9957, 316, 16, 34], "avg_logprob": -0.3579545370256058, "compression_ratio": 3.688311688311688, "no_speech_prob": 0.0, "words": [{"start": 1659.86, "end": 1660.9, "word": "وانتجت", "probability": 0.560107421875}, {"start": 1660.9, "end": 1661.52, "word": " العلاقة", "probability": 0.5752360026041666}, {"start": 1661.52, "end": 1661.88, "word": " بين", "probability": 0.82275390625}, {"start": 1661.88, "end": 1661.94, "word": " مرتبة", "probability": 0.287353515625}, {"start": 1661.94, "end": 1662.34, "word": " الهيموغلوبين", "probability": 0.616973876953125}, {"start": 1662.34, "end": 1662.66, "word": " A1C", "probability": 0.7591959635416666}, {"start": 1662.66, "end": 1664.5, "word": " ومرتبة", "probability": 0.6619873046875}, {"start": 1664.5, "end": 1665.88, "word": " الهيموغلوبين", "probability": 0.8065185546875}, {"start": 1665.88, "end": 1667.18, "word": " A1C", "probability": 0.8806966145833334}, {"start": 1667.18, "end": 1667.62, "word": " ومرتبة", "probability": 0.6365966796875}, {"start": 1667.62, "end": 1667.84, "word": " الهيموغلوبين", "probability": 0.89971923828125}, {"start": 1667.84, "end": 1668.36, "word": " A1C", "probability": 0.8966471354166666}, {"start": 1668.36, "end": 1669.92, "word": " ومرتبة", "probability": 0.60772705078125}, {"start": 1669.92, "end": 1672.0, "word": " الهيموغلوبين", "probability": 0.93829345703125}, {"start": 1672.0, "end": 1673.64, "word": " A1C", "probability": 0.9708658854166666}, {"start": 1673.64, "end": 1678.04, "word": " ومرتبة", "probability": 0.62982177734375}, {"start": 1678.04, "end": 1679.6, "word": " الهيموغلوبين", "probability": 0.95855712890625}, {"start": 1679.6, "end": 1679.92, "word": " A1C", "probability": 0.9879557291666666}, {"start": 1679.92, "end": 1682.4, "word": " ومرتبة", "probability": 0.695281982421875}, {"start": 1682.4, "end": 1683.46, "word": " الهيموغلوبين", "probability": 0.969970703125}, {"start": 1683.46, "end": 1683.46, "word": " A1C", "probability": 0.9931640625}], "temperature": 1.0}, {"id": 74, "seek": 171306, "start": 1685.66, "end": 1713.06, "text": "وبالتالي ما زال في لينا correlation بيجي ممكن إحنا من خلال ال percentage ل ال hemoglobin A1C ممكن نحدد جداش أو نعمل estimation ل ال average glucose عند هذا المريض و من خلال هذه العلاقة قاملوا اللي هو regression equation اللي هي ال formula عندنا ال estimated", "tokens": [37746, 6027, 2655, 6027, 1829, 19446, 30767, 6027, 8978, 5296, 9957, 995, 20009, 4724, 1829, 7435, 1829, 3714, 43020, 11933, 5016, 8315, 9154, 16490, 1211, 6027, 2423, 9668, 5296, 2423, 8636, 45841, 13496, 316, 16, 34, 3714, 43020, 8717, 24401, 3215, 10874, 3215, 33599, 34051, 8717, 25957, 1211, 35701, 5296, 2423, 4274, 23997, 43242, 23758, 9673, 16572, 11242, 4032, 9154, 16490, 1211, 6027, 29538, 18863, 15040, 28671, 12174, 10943, 1211, 14407, 13672, 1829, 31439, 24590, 5367, 13672, 1829, 39896, 2423, 8513, 43242, 8315, 2423, 14109], "avg_logprob": 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short term و لأن الجلاجات الهيموجلوبين لأ ال long term و هنا عندنا ال 1,5-anhydroglucitol لأ اللي هو ال intermediate term و من خلال فحصنا لل 1,5-AG", "tokens": [5172, 5016, 9381, 19753, 34740, 13672, 1829, 3714, 43020, 7251, 14851, 9778, 40448, 24976, 39184, 19376, 1433, 1975, 5016, 8315, 13412, 38688, 8315, 16472, 2423, 1563, 1311, 541, 5296, 10721, 2423, 2099, 1433, 4032, 5296, 33456, 25724, 1211, 26108, 9307, 2423, 3224, 32640, 29245, 1211, 37746, 9957, 5296, 10721, 2423, 938, 1433, 4032, 34105, 43242, 8315, 2423, 502, 11, 20, 12, 50214, 6655, 6675, 75, 1311, 21086, 5296, 10721, 13672, 1829, 31439, 2423, 19376, 1433, 4032, 9154, 16490, 1211, 6027, 6156, 5016, 9381, 8315, 24976, 502, 11, 20, 12, 50228], "avg_logprob": -0.3384271919072329, "compression_ratio": 1.5845410628019323, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1728.91, "end": 1729.41, "word": "فحص", "probability": 0.7882486979166666}, {"start": 1729.41, "end": 1729.83, "word": " آخر", "probability": 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2639.87, "end": 2639.99, "word": " إذا", "probability": 0.82373046875}, {"start": 2639.99, "end": 2640.43, "word": " كان", "probability": 0.994140625}, {"start": 2640.43, "end": 2641.09, "word": " أكبر", "probability": 0.9684244791666666}, {"start": 2641.09, "end": 2641.29, "word": " من", "probability": 0.96435546875}, {"start": 2641.29, "end": 2641.69, "word": " ستين", "probability": 0.9773763020833334}, {"start": 2641.69, "end": 2641.99, "word": " كيلو", "probability": 0.9698893229166666}, {"start": 2641.99, "end": 2642.33, "word": " تلتن", "probability": 0.9173583984375}, {"start": 2642.33, "end": 2643.41, "word": " يبقى", "probability": 0.900390625}, {"start": 2643.41, "end": 2644.31, "word": " بيسلهوش", "probability": 0.7153727213541666}, {"start": 2644.31, "end": 2644.87, "word": " فيلتريش", "probability": 0.60400390625}, {"start": 2644.87, "end": 2645.13, "word": " يفضل", "probability": 0.778106689453125}, {"start": 2645.13, "end": 2645.43, "word": " موجود", "probability": 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وبالتالي هذا بيسمح بمرور اللي هو proteins اللي ال molecular weight بتاعتها أكبر من ستين kilo Dalton اللي هو زي ال album و بالتالي بنلاقي أنه بدأ يصير فينا concentration أعلى من هذه ال proteins في ال urine", "tokens": [41185, 2423, 2423, 30082, 9673, 29245, 23328, 3660, 8978, 2423, 1410, 373, 4889, 46599, 6027, 2655, 6027, 1829, 23758, 4724, 1829, 38251, 5016, 4724, 29973, 13063, 13672, 1829, 31439, 15577, 13672, 1829, 2423, 19046, 3364, 39894, 995, 34268, 11296, 5551, 4117, 26890, 9154, 8608, 2655, 9957, 21112, 17357, 1756, 13672, 1829, 31439, 30767, 1829, 2423, 6030, 4032, 20666, 2655, 6027, 1829, 44945, 15040, 38436, 14739, 3224, 47525, 10721, 7251, 9381, 13546, 8978, 8315, 9856, 5551, 3615, 23942, 9154, 29538, 2423, 15577, 8978, 2423, 27638], "avg_logprob": -0.14476102941176472, "compression_ratio": 1.6167400881057268, "no_speech_prob": 7.152557373046875e-07, "words": [{"start": 2650.79, "end": 2652.33, "word": "في", "probability": 0.95703125}, {"start": 2652.33, "end": 2653.03, 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"end": 2668.97, "word": " اللي", "probability": 0.986328125}, {"start": 2668.97, "end": 2669.15, "word": " هو", "probability": 0.59619140625}, {"start": 2669.15, "end": 2670.03, "word": " زي", "probability": 0.970947265625}, {"start": 2670.03, "end": 2670.45, "word": " ال", "probability": 0.9091796875}, {"start": 2670.45, "end": 2670.71, "word": " album", "probability": 0.94677734375}, {"start": 2670.71, "end": 2670.93, "word": " و", "probability": 0.71044921875}, {"start": 2670.93, "end": 2671.31, "word": " بالتالي", "probability": 0.8741455078125}, {"start": 2671.31, "end": 2671.71, "word": " بنلاقي", "probability": 0.82373046875}, {"start": 2671.71, "end": 2672.53, "word": " أنه", "probability": 0.7198486328125}, {"start": 2672.53, "end": 2674.15, "word": " بدأ", "probability": 0.90771484375}, {"start": 2674.15, "end": 2674.39, "word": " يصير", "probability": 0.9085286458333334}, {"start": 2674.39, "end": 2674.81, "word": " فينا", "probability": 0.58660888671875}, {"start": 2674.81, 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16247, 46152, 20498, 9957, 13672, 1829, 39894, 3794, 1211, 4587, 15058, 8978, 2423, 27638, 39894, 3615, 9566, 1829, 18877, 18871, 11331, 6027, 3660], "avg_logprob": -0.21234809731443724, "compression_ratio": 1.188034188034188, "no_speech_prob": 1.1324882507324219e-06, "words": [{"start": 2681.55, "end": 2682.05, "word": "يبقى", "probability": 0.8602294921875}, {"start": 2682.05, "end": 2683.11, "word": " متابعتنا", "probability": 0.9736328125}, {"start": 2683.11, "end": 2684.59, "word": " لكميات", "probability": 0.8819580078125}, {"start": 2684.59, "end": 2685.25, "word": " الألبومين", "probability": 0.75885009765625}, {"start": 2685.25, "end": 2685.39, "word": " اللي", "probability": 0.9130859375}, {"start": 2685.39, "end": 2685.73, "word": " بتسلق", "probability": 0.49798583984375}, {"start": 2685.73, "end": 2686.43, "word": " execution", "probability": 0.44091796875}, {"start": 2686.43, "end": 2687.83, "word": " في", "probability": 0.974609375}, {"start": 2687.83, "end": 2688.23, "word": " ال", "probability": 0.9169921875}, {"start": 2688.23, "end": 2688.61, "word": " urine", "probability": 0.8369140625}, {"start": 2688.61, "end": 2689.61, "word": " بتعطي", "probability": 0.97509765625}, {"start": 2689.61, "end": 2690.67, "word": " indication", "probability": 0.9189453125}, {"start": 2690.67, "end": 2691.37, "word": " عن", "probability": 0.99169921875}, {"start": 2691.37, "end": 2692.13, "word": " حالة", "probability": 0.9969075520833334}], "temperature": 1.0}, {"id": 118, "seek": 271929, "start": 2692.61, "end": 2719.29, "text": "الـ microvessels في الكدن وبالتالي الـ risk للإصابة بالـ diabetic nephropathy أو يعني مستقبلا بالـ end-stage renal disease يبقى persistent album in execution rate greater than 20 microgram per minute represents a twenty-fold greater risk for the development of clinically overt renal disease", "tokens": [6027, 39184, 4532, 85, 442, 1625, 8978, 33251, 3215, 1863, 46599, 6027, 2655, 6027, 1829, 2423, 39184, 3148, 24976, 28814, 9381, 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لمستويات ال album بال urine مهمة", "tokens": [6027, 39184, 24875, 71, 1513, 9527, 34051, 33688, 9381, 16758, 3660, 20666, 39184, 12883, 304, 35360, 37495, 8592, 7649, 39896, 4117, 9673, 2655, 16758, 27884, 32767, 14851, 45865, 9307, 2423, 6030, 20666, 27638, 3714, 16095, 3660], "avg_logprob": -0.1998521911131369, "compression_ratio": 1.1496062992125984, "no_speech_prob": 2.980232238769531e-07, "words": [{"start": 2817.85, "end": 2818.73, "word": "الـ", "probability": 0.86865234375}, {"start": 2818.73, "end": 2819.41, "word": " Nephropathy", "probability": 0.79949951171875}, {"start": 2819.41, "end": 2820.27, "word": " أو", "probability": 0.8798828125}, {"start": 2820.27, "end": 2821.03, "word": " الإصابة", "probability": 0.97021484375}, {"start": 2821.03, "end": 2821.89, "word": " بالـ", "probability": 0.82275390625}, {"start": 2821.89, "end": 2822.41, "word": " Renal", "probability": 0.8037109375}, {"start": 2822.41, "end": 2823.49, "word": " Disease", "probability": 0.86767578125}, 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0.8566080729166666}, {"start": 2941.62, "end": 2942.44, "word": " حسن", "probability": 0.7775065104166666}], "temperature": 1.0}, {"id": 128, "seek": 296844, "start": 2942.96, "end": 2968.44, "text": "من اللي هو يعني عمل اللي هو الأعصاب أو ال neurons و الدراسة التالتة قللوا ال hemoglobin ONC من تمانية إلى سبعة وهذا برضه قلل من ال incidence ل ال complications زي الwaritinopathy و ال nephropathy و أيضا ال cardiovascular disease", "tokens": [27842, 13672, 1829, 31439, 37495, 22653, 6225, 42213, 13672, 1829, 31439, 16247, 3615, 9381, 16758, 34051, 2423, 22027, 4032, 32748, 23557, 3794, 3660, 16712, 6027, 2655, 3660, 12174, 1211, 1211, 14407, 2423, 8636, 45841, 13496, 9299, 34, 9154, 46811, 7649, 10632, 30731, 8608, 3555, 27884, 37037, 15730, 4724, 43042, 3224, 12174, 1211, 1211, 9154, 2423, 41726, 5296, 2423, 26566, 30767, 1829, 2423, 6925, 270, 259, 404, 9527, 4032, 2423, 408, 950, 1513, 9527, 4032, 36632, 11242, 995, 2423, 31786, 4752], "avg_logprob": -0.18894675337238076, "compression_ratio": 1.5302325581395348, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 2942.96, "end": 2944.0, "word": "من", "probability": 0.94482421875}, {"start": 2944.0, "end": 2944.3, "word": " اللي", "probability": 0.90625}, {"start": 2944.3, "end": 2944.7, "word": " هو", "probability": 0.9921875}, {"start": 2944.7, "end": 2946.44, "word": " يعني", "probability": 0.944091796875}, {"start": 2946.44, "end": 2948.34, "word": " عمل", "probability": 0.984130859375}, {"start": 2948.34, "end": 2948.52, "word": " اللي", "probability": 0.99072265625}, {"start": 2948.52, "end": 2948.66, "word": " هو", "probability": 0.98291015625}, {"start": 2948.66, "end": 2949.32, "word": " الأعصاب", "probability": 0.9697265625}, {"start": 2949.32, "end": 2949.86, "word": " أو", "probability": 0.92333984375}, {"start": 2949.86, "end": 2949.96, "word": " ال", "probability": 0.77294921875}, {"start": 2949.96, "end": 2950.34, "word": " neurons", "probability": 0.7060546875}, {"start": 2950.34, "end": 2951.52, "word": " و", "probability": 0.69775390625}, {"start": 2951.52, "end": 2951.94, "word": " الدراسة", "probability": 0.8863525390625}, {"start": 2951.94, "end": 2952.56, "word": " التالتة", "probability": 0.9718017578125}, {"start": 2952.56, "end": 2953.6, "word": " قللوا", "probability": 0.88525390625}, {"start": 2953.6, "end": 2953.98, "word": " ال", "probability": 0.9892578125}, {"start": 2953.98, "end": 2954.58, "word": " hemoglobin", "probability": 0.88232421875}, {"start": 2954.58, "end": 2954.86, "word": " ONC", "probability": 0.564208984375}, {"start": 2954.86, "end": 2954.98, "word": " من", "probability": 0.9814453125}, {"start": 2954.98, "end": 2955.46, "word": " تمانية", "probability": 0.760986328125}, {"start": 2955.46, "end": 2956.2, "word": " إلى", "probability": 0.8955078125}, {"start": 2956.2, "end": 2956.82, "word": " سبعة", "probability": 0.96337890625}, {"start": 2956.82, "end": 2957.92, "word": " وهذا", "probability": 0.851806640625}, {"start": 2957.92, "end": 2958.34, "word": " برضه", "probability": 0.98486328125}, {"start": 2958.34, "end": 2959.18, "word": " قلل", "probability": 0.9949544270833334}, {"start": 2959.18, "end": 2959.96, "word": " من", "probability": 0.9951171875}, {"start": 2959.96, "end": 2960.42, "word": " ال", "probability": 0.98779296875}, {"start": 2960.42, "end": 2960.94, "word": " incidence", "probability": 0.6220703125}, {"start": 2960.94, "end": 2961.2, "word": " ل", "probability": 0.77294921875}, {"start": 2961.2, "end": 2961.34, "word": " ال", "probability": 0.6279296875}, {"start": 2961.34, "end": 2961.94, "word": " complications", "probability": 0.97412109375}, {"start": 2961.94, "end": 2962.38, "word": " زي", "probability": 0.963134765625}, {"start": 2962.38, "end": 2963.18, "word": " الwaritinopathy", "probability": 0.6766153971354166}, {"start": 2963.18, "end": 2963.36, "word": " و", "probability": 0.93798828125}, {"start": 2963.36, "end": 2964.16, "word": " ال", "probability": 0.467529296875}, {"start": 2964.16, "end": 2964.72, "word": " nephropathy", "probability": 0.8519287109375}, {"start": 2964.72, "end": 2964.92, "word": " و", "probability": 0.7001953125}, {"start": 2964.92, "end": 2965.4, "word": " أيضا", "probability": 0.8865559895833334}, {"start": 2965.4, "end": 2965.68, "word": " ال", "probability": 0.9306640625}, {"start": 2965.68, "end": 2966.72, "word": " cardiovascular", "probability": 0.67822265625}, {"start": 2966.72, "end": 2968.44, "word": " disease", "probability": 0.9404296875}], "temperature": 1.0}, {"id": 129, "seek": 298691, "start": 2971.15, "end": 2986.91, "text": "هيك منكن ان نتهينا من اللي هي محاضرة ال debitas maletas الجزئين و بيضل عندنا ال case studies اللي هنشوف ان شاء الله في اللقاء الوجاهي و يعطيكوا الف عافية", "tokens": [3224, 1829, 4117, 9154, 19452, 16472, 8717, 47395, 1829, 8315, 9154, 13672, 1829, 39896, 3714, 5016, 46958, 25720, 2423, 3001, 14182, 2806, 35120, 25724, 11622, 19986, 9957, 4032, 4724, 1829, 11242, 1211, 43242, 8315, 2423, 1389, 5313, 13672, 1829, 8032, 1863, 8592, 38688, 16472, 13412, 16606, 21984, 8978, 13672, 4587, 16606, 2423, 29245, 40294, 1829, 4032, 37495, 9566, 1829, 4117, 14407, 27188, 6225, 31845, 10632], "avg_logprob": -0.27485794641754846, "compression_ratio": 1.5365853658536586, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 2971.15, "end": 2971.57, "word": "هيك", "probability": 0.8567708333333334}, {"start": 2971.57, "end": 2971.99, "word": " منكن", "probability": 0.849609375}, {"start": 2971.99, "end": 2972.37, "word": " ان", "probability": 0.498291015625}, {"start": 2972.37, "end": 2972.97, "word": " نتهينا", "probability": 0.758453369140625}, {"start": 2972.97, "end": 2973.21, "word": " من", "probability": 0.974609375}, {"start": 2973.21, "end": 2973.45, "word": " اللي", "probability": 0.71728515625}, {"start": 2973.45, "end": 2973.65, "word": " هي", "probability": 0.92041015625}, {"start": 2973.65, "end": 2974.31, "word": " محاضرة", "probability": 0.97802734375}, {"start": 2974.31, "end": 2974.47, "word": " ال", "probability": 0.2318115234375}, {"start": 2974.47, "end": 2974.87, "word": " debitas", "probability": 0.2198028564453125}, {"start": 2974.87, "end": 2975.37, "word": " maletas", "probability": 0.5494384765625}, {"start": 2975.37, "end": 2976.11, "word": " الجزئين", "probability": 0.9580078125}, {"start": 2976.11, "end": 2977.31, "word": " و", "probability": 0.77294921875}, {"start": 2977.31, "end": 2977.67, "word": " بيضل", "probability": 0.66046142578125}, {"start": 2977.67, "end": 2978.15, "word": " عندنا", "probability": 0.8251953125}, {"start": 2978.15, "end": 2978.39, "word": " ال", "probability": 0.72998046875}, {"start": 2978.39, "end": 2978.69, "word": " case", "probability": 0.97021484375}, {"start": 2978.69, "end": 2979.29, "word": " studies", "probability": 0.9638671875}, {"start": 2979.29, "end": 2979.71, "word": " اللي", "probability": 0.935546875}, {"start": 2979.71, "end": 2980.19, "word": " هنشوف", 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\ No newline at end of file
diff --git a/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/wr_r91FrC-Q_raw.srt b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/wr_r91FrC-Q_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..ce0eedcb7ad568e1ed3216453cec1214a83cfe46
--- /dev/null
+++ b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/wr_r91FrC-Q_raw.srt
@@ -0,0 +1,2356 @@
+1
+00:00:02,700 --> 00:00:06,780
+طيب بما يتعلق بيه ال management ليه ال diabetes
+
+2
+00:00:06,780 --> 00:00:13,900
+patients في عندنا ال acute management يعني للي
+
+3
+00:00:13,900 --> 00:00:19,940
+اللي هو ال acute ممكن cases
+
+4
+00:00:19,940 --> 00:00:25,320
+و في عندنا اللي هو في ال chronic بالنسبة ل ال
+
+5
+00:00:25,320 --> 00:00:33,040
+acute في عندنا من ال ..ال conditions اللي ممكن
+
+6
+00:00:33,040 --> 00:00:37,220
+يصاب فيها ال .. الناس المصابين بالدهبيتاس، فيه أن
+
+7
+00:00:37,220 --> 00:00:41,740
+الدهبات ال ketoacidosis، فيه أن hyperosmolar non
+
+8
+00:00:41,740 --> 00:00:46,540
+-ketotic coma و hypoglycemia
+
+9
+00:00:48,230 --> 00:00:52,410
+طبعا حالات المختلفة هذه أكيد المختبر بيلعب دور مهم
+
+10
+00:00:52,410 --> 00:00:59,250
+في ال diagnosis لهذه الحالات المختلفة وأكيد برضه
+
+11
+00:00:59,250 --> 00:01:04,830
+له دور مهم في المتابعة ومتابعة الألاج اللي هيعطاه
+
+12
+00:01:04,830 --> 00:01:13,010
+للمرضى في هذه الحالات الثلاثة من الفحوصات المختلفة
+
+13
+00:01:13,010 --> 00:01:20,220
+اللي بتتم سواءاللي طبعا بداية ال diagnosis و تحديد
+
+14
+00:01:20,220 --> 00:01:27,420
+العلاج اللازم و لغاية طبعا ما يصل ال glucose
+
+15
+00:01:27,420 --> 00:01:31,940
+concentration يعني فيه اللي هي ال range الطبيعية
+
+16
+00:01:33,330 --> 00:01:37,670
+عندها ال glucose in blood and urine و هذه الفحوصات
+
+17
+00:01:37,670 --> 00:01:41,050
+اللي بتتم فيها ان ال ketones برضه in blood and
+
+18
+00:01:41,050 --> 00:01:45,650
+urine أكيد ال acid base ال status ال pH و ال
+
+19
+00:01:45,650 --> 00:01:51,910
+bicarbonate level اللكتيت و أيضا فحوصات اللي لها
+
+20
+00:01:51,910 --> 00:01:54,730
+علاقة ممكن بال dehydration
+
+21
+00:01:56,660 --> 00:02:00,780
+أو المتعلقة بالعلاج الـ Dialytics السابقة بالمثال
+
+22
+00:02:00,780 --> 00:02:07,360
+في أن البوتاسيوم والسوديوم الفوسفات وأيضا ال
+
+23
+00:02:07,360 --> 00:02:13,840
+Osmolality من هذه الفحصات في أن ال ketone bodies
+
+24
+00:02:13,840 --> 00:02:18,600
+development of ketosis requires changes in both
+
+25
+00:02:18,600 --> 00:02:26,520
+adipose tissue and the liverPrimary substrate for
+
+26
+00:02:26,520 --> 00:02:29,300
+ketone body formation are free fatty acids from
+
+27
+00:02:29,300 --> 00:02:39,480
+adipose stores طبعا ال ketone bodies بتنتج بتم
+
+28
+00:02:39,480 --> 00:02:49,460
+إنتاجها طبعا من خلال ال lipolysis طبعا في نقص في
+
+29
+00:02:49,460 --> 00:02:56,850
+ال insulinلأن الـ Ketosis يعني عادة بتظهر عند اللي
+
+30
+00:02:56,850 --> 00:03:00,010
+هو المرضى بالنوع الأول الـ Type 1 diabetes ماليتاس
+
+31
+00:03:00,630 --> 00:03:05,450
+ونادرا ما نشوف ناس عندهم الـ type 2 diabetes
+
+32
+00:03:05,450 --> 00:03:12,030
+mellitus و عندهم ketosis ليش؟ لأنه الناس اللي هو
+
+33
+00:03:12,030 --> 00:03:14,410
+مرضى الـ type 2 diabetes mellitus في عندهم
+
+34
+00:03:14,410 --> 00:03:18,350
+insulin، ال insulin موجود وبالتالي ال insulin ممكن
+
+35
+00:03:18,350 --> 00:03:23,070
+يعمل inhibition على ال alpha cells و يقلل من
+
+36
+00:03:23,070 --> 00:03:28,480
+الجلوكاجون، لكنبمرضى النوع الاول زى ما حكينا سابقا
+
+37
+00:03:28,480 --> 00:03:33,380
+ان فيانا absolute deficiency of انسولين وبالتالي
+
+38
+00:03:33,380 --> 00:03:37,980
+ال inhibitory effect للانسولين على ال alpha cells
+
+39
+00:03:37,980 --> 00:03:41,960
+مش موجودة وبالتالي ال alpha cells هتنتج glucagon
+
+40
+00:03:41,960 --> 00:03:48,980
+وهيكون فيانا gluconeogenesisبالتالي سيكون هناك
+
+41
+00:03:48,980 --> 00:03:55,100
+breakdown للدهون وإنتاج لكميات كبيرة من ال ketone
+
+42
+00:03:55,100 --> 00:03:56,280
+bodies
+
+43
+00:03:59,780 --> 00:04:04,780
+الدول طبعا يعني بيصير فيها تخزين في الكبد على شكل
+
+44
+00:04:04,780 --> 00:04:09,260
+الـ Triglycerides وطبعا الـ Triglycerides هذه ممكن
+
+45
+00:04:09,260 --> 00:04:12,620
+تحمل على الـ VLDL اللي هو الـ Very Low Density
+
+46
+00:04:12,620 --> 00:04:19,380
+Lipoprotein ويصلها Release لتوزيع Limits على
+
+47
+00:04:19,380 --> 00:04:20,940
+الخلايا
+
+48
+00:04:24,370 --> 00:04:26,590
+بالنسبة الـ In contrast to other tissues، the
+
+49
+00:04:26,590 --> 00:04:30,790
+brain cannot use free fatty acids for energy
+
+50
+00:04:30,790 --> 00:04:35,630
+وبالتالي، في عندنا اللي هو الـ ketone bodies اللي
+
+51
+00:04:35,630 --> 00:04:39,810
+بتتكون و اللي ممكن يستخدمها البرن When glucose is
+
+52
+00:04:39,810 --> 00:04:42,030
+unavailable, ketone bodies supply the vast
+
+53
+00:04:42,030 --> 00:04:48,450
+majority of the brain's energyوإذا كان صار فيه صوم
+
+54
+00:04:48,450 --> 00:04:53,030
+اللي هو لأ تلات أيام ketone bodies provide 30
+
+55
+00:04:53,030 --> 00:04:56,250
+percent to 40 percent of the body's energy
+
+56
+00:04:56,250 --> 00:04:57,410
+requirement
+
+57
+00:04:59,780 --> 00:05:04,780
+يبقى أن الـ ketosis و الارتفاع في ال ketone bodies
+
+58
+00:05:04,780 --> 00:05:09,820
+يعني بيصير في ال uncontrolled diabetes اللي بنحكي
+
+59
+00:05:09,820 --> 00:05:15,060
+على يعني بشكل أخص على اللي هو ال type 1 زي ما
+
+60
+00:05:15,060 --> 00:05:18,260
+قولنا هذا كان في عندنا low insulin concentration
+
+61
+00:05:18,260 --> 00:05:24,540
+هذا حيزيد من ال lipolysis و بالتالي حيزيد من اللي
+
+62
+00:05:24,540 --> 00:05:27,980
+هو ال plasma free fatty acids و اللي هو تكوين ال
+
+63
+00:05:27,980 --> 00:05:34,870
+ketone bodiesHigher Glucagon to Insulin Ratio، طب
+
+64
+00:05:34,870 --> 00:05:37,910
+عاملا أنقولنا اللي هو ان الخفاعة في الانسولين بتخل
+
+65
+00:05:37,910 --> 00:05:39,990
+ال inhibitor effect على ال alpha cells وبالتالي
+
+66
+00:05:39,990 --> 00:05:43,410
+بيصير في ال readers أن لا concentrations أعلى من
+
+67
+00:05:43,410 --> 00:05:46,850
+ال glucagon وبالتالي أن higher glucagon to insulin
+
+68
+00:05:46,850 --> 00:05:50,290
+ratio هذا اللي هو enhances the fatty acid
+
+69
+00:05:50,290 --> 00:05:56,470
+oxidation in the liverعنا أيضًا الزيادة بالهرمونات
+
+70
+00:05:56,470 --> 00:05:58,890
+الأخرى، اللي هو الـ counterregulatory hormones أو
+
+71
+00:05:58,890 --> 00:06:02,190
+اللي هو الـ hyperglycemic hormones، اللي كلها
+
+72
+00:06:02,190 --> 00:06:07,470
+بتزيد من الـ concentration لاللي هو الـ glucose
+
+73
+00:06:07,470 --> 00:06:12,970
+وممكن يعني تساعد فيه أو يعني تعمل اللي هو
+
+74
+00:06:12,970 --> 00:06:19,690
+simulation للـ lipolysis برضه، وبالتالي لتكوين الـ
+
+75
+00:06:19,690 --> 00:06:22,370
+ketone bodies أو الـ ketogenesis
+
+76
+00:06:25,020 --> 00:06:27,820
+من الـ Ketone bodies طبعاً في أن الـ Acetoacetate
+
+77
+00:06:28,970 --> 00:06:31,610
+المجموعة الصغيرة تتكوّن من الـ spontaneous
+
+78
+00:06:31,610 --> 00:06:37,450
+decarboxylation وبتكون عندنا أسيتون ولكن أكتر منها
+
+79
+00:06:37,450 --> 00:06:41,450
+تتحول إلى الـ Beta-hydroxybutyrate وهدول اللي هو
+
+80
+00:06:41,450 --> 00:06:49,250
+التلاتة body كيتون اللي بتكون موجودة في الدم
+
+81
+00:06:49,250 --> 00:06:55,550
+والأسيتون ممكن يطلع مع النفس اللي هو خلال ال
+
+82
+00:06:55,550 --> 00:06:59,560
+exhalationزي ما هو واضح بالفigure هان وإن ال
+
+83
+00:06:59,560 --> 00:07:03,640
+acetoacetate جزء منه بتحول إلى acetone اللي هو عن
+
+84
+00:07:03,640 --> 00:07:07,440
+طريق اللي هو دي carboxylation وإن اللي هو الجزء
+
+85
+00:07:07,440 --> 00:07:13,040
+الأكبر بتحول إلى beta-hydroxybutyrate
+
+86
+00:07:15,670 --> 00:07:19,510
+الزيادة في تكوين ال ketone bodies هيؤدي إلى ارتفاع
+
+87
+00:07:19,510 --> 00:07:22,110
+ال concentration ل ال ketone bodies في الدم
+
+88
+00:07:22,110 --> 00:07:28,830
+وبالتالي هيصير فينا كيتونيميا وأيضا الارتفاع هذا
+
+89
+00:07:28,830 --> 00:07:32,010
+في الدم هيؤدي إلى زيادة ال execution ل ال ketone
+
+90
+00:07:32,010 --> 00:07:36,270
+bodies في ال urine وبالتالي هيكون فينا كيتونوريا
+
+91
+00:07:38,100 --> 00:07:41,320
+ممكن ايضا عندنا ال ketone bodies يعني ايه ممكن
+
+92
+00:07:41,320 --> 00:07:48,540
+تتكون في حالات اللي هو ال .. النقص في ال
+
+93
+00:07:48,540 --> 00:07:51,800
+carbohydrates زي اللي هو the starvation او
+
+94
+00:07:51,800 --> 00:07:56,820
+frequent vomiting او decrease used of
+
+95
+00:07:56,820 --> 00:07:57,820
+carbohydrates
+
+96
+00:08:00,160 --> 00:08:04,520
+زي في حالات اللي هو ال diabetes mellitus أو في
+
+97
+00:08:04,520 --> 00:08:10,180
+حالات اللي هو ال glycogen storage disease type one
+
+98
+00:08:10,180 --> 00:08:17,880
+اللي هو somavone geric diseaseعنا برضه ال .. ال ..
+
+99
+00:08:17,880 --> 00:08:21,440
+ال .. اللي هو ال diet ال .. الموضة اللي هو الآن
+
+100
+00:08:21,440 --> 00:08:27,980
+اللي هو ال keto تمام؟ هذا برضه بيزيد من ال ketone
+
+101
+00:08:27,980 --> 00:08:30,980
+bodies اللي هو ال popular high fat low
+
+102
+00:08:30,980 --> 00:08:33,480
+carbohydrate diet high بيبقى في عنا low
+
+103
+00:08:33,480 --> 00:08:38,060
+carbohydrate هان اللي هو برضه كيتوجينيكوي بيؤدي
+
+104
+00:08:38,060 --> 00:08:42,360
+إلى زيادة في ال ketone bodies في الدم
+
+105
+00:08:45,300 --> 00:08:50,640
+أكتر حالات ال ketoacidosis بنلاقيها عند اللي هو ال
+
+106
+00:08:50,640 --> 00:08:53,220
+diabetes mellitus زي ما قلنا اللي هو بشكل خاص عند
+
+107
+00:08:53,220 --> 00:08:56,780
+اللي هو ال type 1 diabetes mellitus و أيضا عند
+
+108
+00:08:56,780 --> 00:09:01,780
+اللي هو ال .. الناس اللي بيتناولوا يعني كحول
+
+109
+00:09:01,780 --> 00:09:07,740
+بكميات كبيرة وهذا اللي طبعا ال .. ال .. سبب حدوث
+
+110
+00:09:07,740 --> 00:09:13,580
+ال ketoacidosis عند الناس اللي بيتناولوا كحول لأنه
+
+111
+00:09:13,580 --> 00:09:18,570
+بيصير في عندنااللي هو impairment لـ conversion of
+
+112
+00:09:18,570 --> 00:09:22,950
+lactate to pyruvate وهذا بيزيد من ال hypothesis
+
+113
+00:09:22,950 --> 00:09:29,470
+وبالتالي بيزيد من تكوين ال ketone bodies
+
+114
+00:09:32,160 --> 00:09:36,760
+حسب توصيات الـ American Diabetes Association أنه
+
+115
+00:09:36,760 --> 00:09:43,220
+لازم يكون فيه متابعة للناس اللي عندهم Diabetes
+
+116
+00:09:43,220 --> 00:09:44,900
+وخاصة اللي هو زي ما قلنا الـ Type 1 diabetes
+
+117
+00:09:44,900 --> 00:09:48,820
+mellitus pregnancy with a pre-existing diabetes
+
+118
+00:09:48,820 --> 00:09:52,740
+والنساء اللي عندهم gestational diabetes mellitus
+
+119
+00:09:52,740 --> 00:09:57,500
+لابد أن يكون فيه متابعة للـ ketone bodies في ال
+
+120
+00:09:57,500 --> 00:10:01,570
+urineالشباب اللي بتاعة type 1 diabetes smallitis
+
+121
+00:10:01,570 --> 00:10:04,290
+يجب أن يقوموا بالتجارب لكيتونات في حالة مرضى المرض
+
+122
+00:10:04,290 --> 00:10:08,130
+يبقى لأنه زي ما احنا عارفين في الـ acute illness
+
+123
+00:10:08,130 --> 00:10:17,610
+بيزيد عندنا ممكن بعض الهرمونات اللي بترفع او اللي
+
+124
+00:10:17,610 --> 00:10:22,590
+هي تعتبر تعتبر hyperglycemic hormones وبالتالي
+
+125
+00:10:22,590 --> 00:10:27,130
+ممكن تزيد من تكوين ال ketone bodies يبقى ال
+
+126
+00:10:27,130 --> 00:10:30,400
+patients with type 1 diabetes smallitasلازم برضه
+
+127
+00:10:30,400 --> 00:10:33,840
+يتم فحصهم في ال ketones خلال ال acute illness او
+
+128
+00:10:33,840 --> 00:10:37,260
+stress او with consistent increase in blood
+
+129
+00:10:37,260 --> 00:10:39,740
+glucose اذا كان زاد اننا ال glucose عن تلاتمية
+
+130
+00:10:39,740 --> 00:10:45,160
+milligram per deciliter و برضه خلال اللي هو الحمل
+
+131
+00:10:46,190 --> 00:10:51,850
+أو when symptoms of ketoacidosis are present ومن
+
+132
+00:10:51,850 --> 00:10:54,670
+ال symptoms اللي هي ال ketoacidosis اللي هو في
+
+133
+00:10:54,670 --> 00:10:59,010
+عندنا frequent urination extreme thirst طبعا high
+
+134
+00:10:59,010 --> 00:11:04,470
+اللي هو blood sugar و اللي هو برضه طبعا ارتفاع في
+
+135
+00:11:04,470 --> 00:11:11,940
+ال ketones في ال urineقياس الـ ketones سواء في الـ
+
+136
+00:11:11,940 --> 00:11:15,680
+urine أو البلد widely performed in patients with
+
+137
+00:11:15,680 --> 00:11:21,300
+diabetes سواء للـ diagnosis و أيضًا للـ monitoring
+
+138
+00:11:21,300 --> 00:11:27,400
+زي ما حكينا الآن of diabetic ketoacidosis
+
+139
+00:11:30,120 --> 00:11:32,440
+بالنسبة للجزئية التانية اللي هي ال management
+
+140
+00:11:32,440 --> 00:11:39,520
+للوالي chronic و طبعا من خلال الدراسات المختلفة
+
+141
+00:11:39,520 --> 00:11:47,700
+اللي تمت و اللي ربطت بين مستويات الجلوكوز في الدم
+
+142
+00:11:47,700 --> 00:11:51,520
+و ال development of long term complications of
+
+143
+00:11:51,520 --> 00:11:58,060
+diabetes و عشان هيك لازم يكون فيه أنهمتابعة لمرضى
+
+144
+00:11:58,060 --> 00:12:05,220
+السكري باستمرار والمحافظة على levels من ال glucose
+
+145
+00:12:05,220 --> 00:12:10,640
+اللي تكون يعني إلى حد ما قريبة ممكن من ال
+
+146
+00:12:10,640 --> 00:12:13,640
+reference range أو ممكن تكون أعلى شوية لكن مايكونش
+
+147
+00:12:13,640 --> 00:12:18,990
+في عندنا ارتفاع بشكل كبير في ال glucoseلأنه
+
+148
+00:12:18,990 --> 00:12:24,090
+الارتفاع في ال glucose مرتبط بال complications
+
+149
+00:12:24,090 --> 00:12:30,780
+المختلفة اللي ممكن تصير لمرضى السكريبما يتعلق طبعا
+
+150
+00:12:30,780 --> 00:12:36,400
+بيه ال management ل ال patients فيه على مستوى اللي
+
+151
+00:12:36,400 --> 00:12:39,820
+هو القصير وعلى المستوى البعيد طبعا انه ال .. ال
+
+152
+00:12:39,820 --> 00:12:45,040
+short term ممكن من خلال المستويات لglucose وفي
+
+153
+00:12:45,040 --> 00:12:49,840
+عندنا ال long term monitoring من خلال قياس ال
+
+154
+00:12:49,840 --> 00:12:51,880
+glycated proteins
+
+155
+00:12:53,870 --> 00:12:58,850
+الـ detection and monitoring of complications طبعا
+
+156
+00:12:58,850 --> 00:13:04,350
+بالمختبر احنا ممكن نشوف ال complications اللي
+
+157
+00:13:04,350 --> 00:13:09,610
+متعلقة بال kidney disease وبالـ nephropathy وهذا
+
+158
+00:13:09,610 --> 00:13:12,950
+ممكن بيكون من خلال ال kidney function test زي
+
+159
+00:13:12,950 --> 00:13:19,030
+عندنا ال والكاريتانين وبرضه من خلال ال saying
+
+160
+00:13:19,030 --> 00:13:21,010
+urine for albuminuria
+
+161
+00:13:23,400 --> 00:13:30,480
+برضه في حال انه المريض يعني خضع لبعض العلاجات زي
+
+162
+00:13:30,480 --> 00:13:34,200
+اللي هو الـ Islet Cell أو الـ Pancreas
+
+163
+00:13:34,200 --> 00:13:39,640
+Transplantation في انها انفحوصات بالتم ليه هذا
+
+164
+00:13:39,640 --> 00:13:45,040
+المريض اللي هي الـC-Peptide والإنسلين يعني للتأكد
+
+165
+00:13:45,040 --> 00:13:52,500
+انه هذه الخلايا اللي تم زراعتها يعني تعمل بالشكل
+
+166
+00:13:53,150 --> 00:13:57,950
+المطلوب من
+
+167
+00:13:57,950 --> 00:14:04,610
+الفحوصات اللى بتتملى متابعة مرضى السكري انها زى ما
+
+168
+00:14:04,610 --> 00:14:12,030
+ذكرنا فيه ال glucose ال fasting او ال randomطبعا
+
+169
+00:14:12,030 --> 00:14:15,030
+في ال blood أو في ال urine فينا ال glycated
+
+170
+00:14:15,030 --> 00:14:20,150
+proteins اللي هي ال proteinات اللي ارتبط معها ال
+
+171
+00:14:20,150 --> 00:14:23,570
+glucose يعني ال hemoglobin A1C اللي طبعا الأكثر
+
+172
+00:14:23,570 --> 00:14:29,890
+شهرة فينا fractosamine وفينا أيضا glycated serum
+
+173
+00:14:29,890 --> 00:14:31,070
+albumin
+
+174
+00:14:33,480 --> 00:14:39,260
+يعني انه ايضا one five anhydroglucitol او one five
+
+175
+00:14:39,260 --> 00:14:43,640
+a g فيه برضه ال urinary proteins اللي هو
+
+176
+00:14:43,640 --> 00:14:48,840
+البومنوريا زى ما قولنا لمتابعة اللى هو وضع ال
+
+177
+00:14:48,840 --> 00:14:55,340
+kidney البومنوريا اللى هو الدارج عندنا الاسم او
+
+178
+00:14:55,340 --> 00:15:00,320
+معروف اكتر ب microalbuminuriaلكن الان يعني يفضل
+
+179
+00:15:00,320 --> 00:15:03,720
+انه يتم تسميته بقلبه منه ريا زي ما هنشوف
+
+180
+00:15:03,720 --> 00:15:09,180
+proteinuria ال proteins في ال urine و evaluation
+
+181
+00:15:09,180 --> 00:15:15,620
+of complicationsاللي هو من خلال قياس الـ كريتانين
+
+182
+00:15:15,620 --> 00:15:19,780
+للـ kidney function وعنا الكلسترول و الـ tri
+
+183
+00:15:19,780 --> 00:15:26,100
+-glycerides يعني ممكن عشان نشوف اللي هو ال risk
+
+184
+00:15:26,100 --> 00:15:29,960
+اللي ممكن إصابة بالـ cardiovascular diseases
+
+185
+00:15:29,960 --> 00:15:36,920
+بالنسبة لغلاكات ال proteins أحنا هنحكي عن الـ
+
+186
+00:15:36,920 --> 00:15:42,840
+hemoglobin A1Cإذا حد حابب يحكيلنا عن ال agglicated
+
+187
+00:15:42,840 --> 00:15:46,580
+proteins، يشوف مقالة و يحكي عن ال agglicated
+
+188
+00:15:46,580 --> 00:15:49,320
+proteins بيكون كويسة
+
+189
+00:15:52,910 --> 00:15:55,450
+طبعا من الـ glucated proteins عندنا قلنا الـ
+
+190
+00:15:55,450 --> 00:16:02,390
+hemoglobin A1C هو يعني الأكثر شهرة effective in
+
+191
+00:16:02,390 --> 00:16:07,170
+monitoring long term glucose control in people
+
+192
+00:16:07,170 --> 00:16:11,550
+with diabetes mellitus و دي طبعا من الفحوصات اللي
+
+193
+00:16:11,550 --> 00:16:18,520
+لازم يعني تنعمل كل تلت شهور لمرضى السكريلمعرفة
+
+194
+00:16:18,520 --> 00:16:25,260
+يعني معدل مستوى السكر في التلات شهور السابقة ومدى
+
+195
+00:16:25,260 --> 00:16:30,300
+التزام المريض سواء بالعلاج أو بالحمية
+
+196
+00:16:31,840 --> 00:16:35,800
+يجب من خلال الـ Hemoglobin A1C نحصل على الـ
+
+197
+00:16:35,800 --> 00:16:40,460
+Retrospective Index of Integrated Plasma Glucose
+
+198
+00:16:40,460 --> 00:16:44,220
+Values over an expected period of time، وقولنا هي
+
+199
+00:16:44,220 --> 00:16:50,140
+تقريبًا تلت شهور السابقة Aggregated hemoglobin
+
+200
+00:16:50,140 --> 00:16:54,580
+concentrations therefore are invaluableوقمت بعمل
+
+201
+00:16:54,580 --> 00:16:55,040
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+202
+00:16:55,040 --> 00:16:55,580
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+203
+00:16:55,580 --> 00:16:59,460
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+204
+00:16:59,460 --> 00:17:02,520
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+205
+00:17:02,520 --> 00:17:03,080
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+206
+00:17:03,080 --> 00:17:03,360
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+207
+00:17:03,360 --> 00:17:03,360
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+208
+00:17:03,360 --> 00:17:03,400
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+209
+00:17:03,400 --> 00:17:08,960
+عملية عملية عملية عملية عملية عملية عملية عملية ع
+
+210
+00:17:13,010 --> 00:17:15,510
+أيضًا إجلاكات الهيموجلوبين recently been
+
+211
+00:17:15,510 --> 00:17:19,110
+recommended for the diagnosis of diabetes ويمكن
+
+212
+00:17:19,110 --> 00:17:23,610
+هذا ذكرناه سابقًا لكن زي ما قلنا أنه لازم يكون
+
+213
+00:17:23,610 --> 00:17:27,550
+standardized method اللي تم استخدامها ومش أي طريقة
+
+214
+00:17:28,930 --> 00:17:36,670
+وبرضه مستويات الـ Hemoglobin A1C بتعتبر measure of
+
+215
+00:17:36,670 --> 00:17:39,430
+risk for the development of microvascular
+
+216
+00:17:39,430 --> 00:17:44,910
+complications of diabetes يعني كل ما كان ال
+
+217
+00:17:44,910 --> 00:17:52,030
+Hemoglobin A1C ال percentage أعلى، معناته المريض
+
+218
+00:17:52,030 --> 00:17:56,790
+هذا at higher risk للإصابة بالmicrovascular
+
+219
+00:17:56,790 --> 00:17:57,750
+complications
+
+220
+00:18:00,810 --> 00:18:05,670
+الهيموجلوبين A1C هو المجموعة الكبيرة التي تكون
+
+221
+00:18:05,670 --> 00:18:10,910
+حوالي 80% من الهيموجلوبين A1
+
+222
+00:18:14,630 --> 00:18:20,350
+وعنا الـ Hemoglobin A1 اللي بتكون من Hemoglobin 1A
+
+223
+00:18:20,350 --> 00:18:26,010
+Hemoglobin 1C و Hemoglobin Hemoglobin 1A و
+
+224
+00:18:26,010 --> 00:18:30,650
+Hemoglobin 1B و Hemoglobin 1C تمام؟ فهدول التلاتة
+
+225
+00:18:30,650 --> 00:18:35,570
+بيطلق عليهم Hemoglobin A1 من هدول التلاتة عنا ال
+
+226
+00:18:35,570 --> 00:18:39,790
+major fraction هو ال Hemoglobin A1C و اللي بيمثل
+
+227
+00:18:39,790 --> 00:18:42,010
+80%
+
+228
+00:18:44,730 --> 00:18:48,250
+طبعاً في عندنا برضه يعني أنواع أخرى زي الـ
+
+229
+00:18:48,250 --> 00:18:52,370
+Hemoglobin مثلا A1A اللي هو عبارة عن Hemoglobin A
+
+230
+00:18:52,370 --> 00:18:58,830
+مرتبط مع Fructose Hemoglobin 1A2 اللي هو
+
+231
+00:18:58,830 --> 00:19:03,870
+Hemoglobin A مرتبط مع Glucose 6-Fosfate تمام، يعني
+
+232
+00:19:03,870 --> 00:19:08,030
+في أنواع مختلفة لكن النسبة الأكبر اللي هو الـ
+
+233
+00:19:08,030 --> 00:19:14,500
+Hemoglobin A1C و اللي هي اللي بتتم قياسهاالـ
+
+234
+00:19:14,500 --> 00:19:19,580
+Formation، وطبعاً هذه نقطة مهمة الـ Formation of
+
+235
+00:19:19,580 --> 00:19:23,560
+Glycated Hemoglobin is essentially irreversible
+
+236
+00:19:23,560 --> 00:19:29,500
+وإلا إذا كان reversible يعني مش هيكون دقيق
+
+237
+00:19:29,500 --> 00:19:33,480
+لاستخدامه يبقى الـ Glycated Hemoglobin is
+
+238
+00:19:33,480 --> 00:19:37,560
+essentially irreversible مزال صار فينا ارتباطبين
+
+239
+00:19:37,560 --> 00:19:41,920
+الجلوكوز وبين الـ Hemoglobin يبقى مش هيصير فيه
+
+240
+00:19:41,920 --> 00:19:47,920
+اللي هو effect لجلوكوز مرة أخرى. The concentration
+
+241
+00:19:47,920 --> 00:19:51,500
+in the blood depends on both the lifespan of the
+
+242
+00:19:51,500 --> 00:19:54,880
+red blood cells هذا اللي هو بيعتمد عليه نسبة
+
+243
+00:19:54,880 --> 00:19:59,380
+لجلوكيت ال Hemoglobin اللي هو عمر الخلايا الدم
+
+244
+00:19:59,380 --> 00:20:06,040
+الحمراء وإنالـ Blood Glucose Concentration في
+
+245
+00:20:06,040 --> 00:20:12,480
+الدم، يبقى دول النقطتين اللي بيتمت عليهم نسبة الـ
+
+246
+00:20:12,480 --> 00:20:19,200
+Glucated Hemoglobin في الدم،
+
+247
+00:20:19,200 --> 00:20:22,820
+يبقى عندها الـ Glucose
+
+248
+00:20:25,970 --> 00:20:32,330
+طبعاً بيرتبط على الـ N-terminal amino group لالو
+
+249
+00:20:32,330 --> 00:20:41,250
+ال beta-chain بداية بيكون أن ال الديمين عبارة عن
+
+250
+00:20:41,250 --> 00:20:48,210
+ال skiff baseو بعد هيك ال aldamine هذه بتتحول إلى
+
+251
+00:20:48,210 --> 00:20:54,130
+ketoamine اللي هو ال hemoglobin A1C يبقى بيصير في
+
+252
+00:20:54,130 --> 00:20:59,590
+عنا rearrangement لال aldamine و بيعطيني ketoamine
+
+253
+00:20:59,590 --> 00:21:04,050
+اللي هو ال hemoglobin A1C يبقى ال hemoglobin A مع
+
+254
+00:21:04,050 --> 00:21:10,470
+ال glucose بيعطيني pre hemoglobin A1Cوهذه الخطوة
+
+255
+00:21:10,470 --> 00:21:17,110
+زي ما هو واضحان الخطوة هذه reversible تمام فالخطوة
+
+256
+00:21:17,110 --> 00:21:20,390
+هذه reversible لكن بعد هيك pre-hemoglobin A1C
+
+257
+00:21:20,390 --> 00:21:25,490
+بيصير في أنا rearrangement لهذا المركب تمام
+
+258
+00:21:25,490 --> 00:21:30,790
+وبيعطيني hemoglobin A1C وهذه الخطوة irreversible
+
+259
+00:21:30,790 --> 00:21:34,990
+زي ما احنا شايفين السهم في اتجاه واحد فقط
+
+260
+00:21:37,890 --> 00:21:41,030
+بالنسبة للارتباط اللي بيصير بين الجلوكوز وبين
+
+261
+00:21:41,030 --> 00:21:45,330
+الهيموجلوبين plasma glucose in the preceding one
+
+262
+00:21:45,330 --> 00:21:48,590
+month determines fifty percent of the hemoglobin
+
+263
+00:21:48,590 --> 00:21:53,290
+A1C يعني لو جينا حكينا على تلت شهور ممكن بالشهر
+
+264
+00:21:53,290 --> 00:21:58,110
+الأول بتكون أنه كمية الارتباط قليلة، بالشهر التاني
+
+265
+00:21:58,110 --> 00:22:02,650
+بتزيد و بالشهر التالت بتكون اللي هو أكتر نسبة
+
+266
+00:22:02,650 --> 00:22:05,350
+وبالتالي plasma glucose in the preceding one month
+
+267
+00:22:06,490 --> 00:22:11,890
+الذي يقوم بتحريك 50% من الهيموجلوبين A1C الآن
+
+268
+00:22:11,890 --> 00:22:17,150
+الشهر اللي قبلي بتكون عندى اللي هو نسبة خمسة
+
+269
+00:22:17,150 --> 00:22:22,810
+وعشرين بالمية و اللي هو طبعا الشهر اللي قبل أو
+
+270
+00:22:22,810 --> 00:22:26,170
+الشهرين اللي قبل بتكون عندنا الخمسة وعشرين بالمية
+
+271
+00:22:26,170 --> 00:22:31,850
+اللي ضايلة ال interpretation لليغلاكات
+
+272
+00:22:31,850 --> 00:22:33,910
+الهيموجلوبين depends on red blood cells لأن احنا
+
+273
+00:22:33,910 --> 00:22:39,790
+بنحكي علىالاضطباط لجلوكوز مع الـ Beta-Chain في
+
+274
+00:22:39,790 --> 00:22:41,710
+الهيموجلوبين الموجود في الـ Red Blood Cells
+
+275
+00:22:41,710 --> 00:22:46,230
+وبالتالي أي إشي هيأثر على عمر الـ Red Blood Cells
+
+276
+00:22:46,230 --> 00:22:50,930
+أكيد هيأثر على الـ Negligated Hemoglobin إذا كانت
+
+277
+00:22:50,930 --> 00:22:55,690
+المريض مع مرض هيمولتك أو أشياء أخرى مع تقسيم حياة
+
+278
+00:22:55,690 --> 00:23:01,190
+الـ Red Blood Cells تظهر تقسيم الـ Negligated
+
+279
+00:23:01,190 --> 00:23:05,870
+Hemoglobinبرضه اذا كانت صار فيه انه الوه
+
+280
+00:23:05,870 --> 00:23:10,010
+significant blood loss يبقى individuals with
+
+281
+00:23:10,010 --> 00:23:14,390
+recent significant blood loss برضه هذا ممكن يعطيني
+
+282
+00:23:14,390 --> 00:23:19,250
+الوه falsely low values يبقى ممكن نيجي نفحص و
+
+283
+00:23:19,250 --> 00:23:23,510
+نلاقي انه ال hemoglobin a1c اللي يعني منخفض لكن
+
+284
+00:23:23,510 --> 00:23:27,550
+هذا هكون falsely low لأنه صار في عندي فقط لا كمية
+
+285
+00:23:27,550 --> 00:23:31,370
+يعني كبيرة من الدم
+
+286
+00:23:33,110 --> 00:23:37,230
+واللي هو طبعا الـ high fraction of younger
+
+287
+00:23:37,230 --> 00:23:43,690
+erythrocytes اللي لسه ماصارش فيه ارتباط لجلوكوز
+
+288
+00:23:43,690 --> 00:23:50,050
+بكميات اللي هو يعني كويسة high إجلاكية
+
+289
+00:23:50,050 --> 00:23:53,470
+الهيموجلوبين برضه هذا من ناحية أخرى ممكن يصير فينا
+
+290
+00:23:53,470 --> 00:23:57,570
+ارتفاع لإجلاكية الهيموجلوبين في حالات ال iron
+
+291
+00:23:57,570 --> 00:24:00,930
+deficiency anemiaيبقى في الـ Iron deficiency
+
+292
+00:24:00,930 --> 00:24:03,770
+anemia اللي هي مجلوب ان اذا نسيب اللاجئ انه ال
+
+293
+00:24:03,770 --> 00:24:08,130
+concentration ارتفعت لكن ال mechanism وكيف بيصير
+
+294
+00:24:08,130 --> 00:24:11,050
+هذا الأمر is unknown
+
+295
+00:24:13,780 --> 00:24:17,100
+طبعا زي ما قلنا إنه الـ Hemoglobin A1C أو الـ
+
+296
+00:24:17,100 --> 00:24:21,060
+Glucated Glucated Protein بشكل عام من اللي هي
+
+297
+00:24:21,060 --> 00:24:27,420
+الفحصات اللي بتتم المفروض بشكل دوري و فعليا العديد
+
+298
+00:24:27,420 --> 00:24:32,920
+من المنظمات اللي يعني معنية بهذا المرض و اللي
+
+299
+00:24:32,920 --> 00:24:38,480
+تعتبر مؤثرة برضه اللي هو بتوصي بفحص الـ Hemoglobin
+
+300
+00:24:38,480 --> 00:24:42,060
+A1C اللي هو بشكل روتيني
+
+301
+00:24:43,260 --> 00:24:46,320
+to document degree of glycemic control and to
+
+302
+00:24:46,320 --> 00:24:50,620
+assess response to a treatment عشان نشوف مدى اللي
+
+303
+00:24:50,620 --> 00:24:53,080
+هو الالتزام زي ما حكينا ويديش اللي هو مستويات
+
+304
+00:24:53,080 --> 00:24:59,160
+السكر عند المريض وايضا استجابة المريض للعلاج
+
+305
+00:25:01,150 --> 00:25:04,390
+الـ Absolute risk of retinopathy and nephropathy
+
+306
+00:25:04,390 --> 00:25:07,710
+were directly proportional to the mean hemoglobin
+
+307
+00:25:07,710 --> 00:25:11,270
+A1C concentration عيب جاء من خلال ال hemoglobin
+
+308
+00:25:11,270 --> 00:25:17,770
+A1C برضه ممكن نشوف ال risk للمريض اللي الإصابة بال
+
+309
+00:25:17,770 --> 00:25:21,550
+complications المختلفة و من خلال الدراسات لجوا أنه
+
+310
+00:25:21,550 --> 00:25:25,150
+each one percent reduction in hemoglobin A1C يعني
+
+311
+00:25:25,150 --> 00:25:31,910
+على سبيل المثال كان تمانية و نزلةكان هذا مصاحب لـ
+
+312
+00:25:31,910 --> 00:25:39,290
+reduction of 37% for microvascular disease و أيضًا
+
+313
+00:25:39,290 --> 00:25:44,170
+كان فينا 21% for death related to diabetes كان في
+
+314
+00:25:44,170 --> 00:25:48,810
+انخفاض برضه reduction اللي هو بنسبة 21% و برضه كان
+
+315
+00:25:48,810 --> 00:25:53,860
+في reduction بنسبة 14%للـ myocardial infarction
+
+316
+00:25:53,860 --> 00:26:00,020
+بقى 1% له تأثير كبير في تقريل ال complications
+
+317
+00:26:00,020 --> 00:26:09,040
+المختلفة في أنه طرق عديدة للفحص لجراكات
+
+318
+00:26:09,040 --> 00:26:11,900
+الهيمoglobins ومنها ال hemoglobin A1C more than
+
+319
+00:26:11,900 --> 00:26:18,110
+150 different methods have been describedالـ ADA
+
+320
+00:26:18,110 --> 00:26:21,750
+ترجح بأن البراتبيرات تستخدم فقط الـ Hemoglobin A1c
+
+321
+00:26:21,750 --> 00:26:28,530
+أساسيات تتعامل مع الـ NGSP يقولنا لازم تكون اللي
+
+322
+00:26:28,530 --> 00:26:33,350
+هو standardized with certified method اللي بدنا
+
+323
+00:26:33,350 --> 00:26:40,030
+نستخدمها سواء لل diagnoses أو للمعاملة
+
+324
+00:26:40,030 --> 00:26:41,710
+للطب
+
+325
+00:26:43,870 --> 00:26:50,550
+وفيها على الموقع الأورجينيزييشي الـ NGSB موجود
+
+326
+00:26:50,550 --> 00:26:58,090
+الطرق المعتمدة من قبلهم بالنسبة
+
+327
+00:26:58,090 --> 00:27:01,470
+لنتيجة الـ hemoglobin A1C reported as a percentage
+
+328
+00:27:01,470 --> 00:27:05,690
+وهذا يعني اللي بيستخدم عندنا of total hemoglobin
+
+329
+00:27:07,250 --> 00:27:11,630
+هذا بناءً على الـ NGSP System لكن في عندنا برضه
+
+330
+00:27:11,630 --> 00:27:15,050
+units أخرى ممكن تستخدم اللي هو بناءً على الـ
+
+331
+00:27:15,050 --> 00:27:17,330
+International Federation of Clinical Chemistry
+
+332
+00:27:17,330 --> 00:27:23,990
+وهذه ال units هي ملي مول لكل مول ملي مول
+
+333
+00:27:23,990 --> 00:27:30,010
+Hemoglobin UNC لكل مول من الهمoglobin
+
+334
+00:27:30,010 --> 00:27:35,310
+Multinational
+
+335
+00:27:35,310 --> 00:27:36,650
+Prospective Study
+
+336
+00:27:39,860 --> 00:27:44,500
+وانتجت العلاقة بين مرتبة الهيموغلوبين A1C ومرتبة
+
+337
+00:27:44,500 --> 00:27:49,920
+الهيموغلوبين A1C ومرتبة الهيموغلوبين A1C ومرتبة
+
+338
+00:27:49,920 --> 00:27:58,040
+الهيموغلوبين A1C ومرتبة
+
+339
+00:27:58,040 --> 00:28:06,320
+الهيموغلوبين A1C ومرتبة الهيموغلوبين A1Cوبالتالي
+
+340
+00:28:06,320 --> 00:28:09,060
+ما زال في لينا correlation بيجي ممكن إحنا من خلال
+
+341
+00:28:09,060 --> 00:28:13,760
+ال percentage ل ال hemoglobin A1C ممكن نحدد جداش
+
+342
+00:28:13,760 --> 00:28:19,100
+أو نعمل estimation ل ال average glucose عند هذا
+
+343
+00:28:19,100 --> 00:28:25,300
+المريض و من خلال هذه العلاقة قاملوا اللي هو
+
+344
+00:28:25,300 --> 00:28:30,060
+regression equation اللي
+
+345
+00:28:30,060 --> 00:28:35,610
+هي ال formula عندنا ال estimatedAverage Glucose
+
+346
+00:28:35,610 --> 00:28:41,630
+بالميلي جرام بالديسليتر بتساوي 28.7 ضرب Hemoglobin
+
+347
+00:28:41,630 --> 00:28:47,070
+A1C ناقص 46.7
+
+348
+00:28:48,910 --> 00:28:53,990
+فحص آخر اللي ممكن يستخدم للـ intermediate term
+
+349
+00:28:53,990 --> 00:28:57,770
+احنا شوفنا ان ال glucose لأ ال short term و لأن
+
+350
+00:28:57,770 --> 00:29:01,490
+الجلاجات الهيموجلوبين لأ ال long term و هنا عندنا
+
+351
+00:29:01,490 --> 00:29:08,230
+ال 1,5-anhydroglucitol لأ اللي هو ال intermediate
+
+352
+00:29:08,230 --> 00:29:18,950
+term و من خلال فحصنا لل 1,5-AGممكن هذا يعكس لنا كم
+
+353
+00:29:18,950 --> 00:29:23,730
+كانت الـ Glucose concentration في اليومين إلى 14
+
+354
+00:29:23,730 --> 00:29:33,370
+يوم السابق الـ 15AG هو عبارة عن Deoxy Form of
+
+355
+00:29:33,370 --> 00:29:36,770
+Glucose زي ما هو واضح أنها بيلفجر هيها الجلوكوز
+
+356
+00:29:36,770 --> 00:29:42,490
+تمام بنزع الـ OH group بيحولوا إلى 15
+
+357
+00:29:42,490 --> 00:29:44,410
+-anhydroglicitol
+
+358
+00:29:46,610 --> 00:29:52,490
+من وين بيجي الـ 1,5-anhydroglycitol originates
+
+359
+00:29:52,490 --> 00:29:57,750
+predominantly from the diet يبقى عندنا الكمية
+
+360
+00:29:57,750 --> 00:30:03,170
+الأكبر الأعظم تيجي من ال diet هو أكتر من 99.9%
+
+361
+00:30:06,060 --> 00:30:13,620
+الان الـ 1,5-anhydroglicitol بسلها filtration و
+
+362
+00:30:13,620 --> 00:30:17,120
+بعدين برجع طبعا في ال .. ال kidney و بعدين برجع
+
+363
+00:30:17,120 --> 00:30:24,420
+بسلها reabsorption عن طريق ال SGLT4 اللي هي Sodium
+
+364
+00:30:24,420 --> 00:30:27,040
+Dependent Glucose Transporter
+
+365
+00:30:29,450 --> 00:30:36,210
+في بعض الدراسات اللي .. اللي تمت و اللي استخدموا
+
+366
+00:30:36,210 --> 00:30:42,500
+فيها ال .. ال salivaليه قياس ال one five ag
+
+367
+00:30:42,500 --> 00:30:48,300
+ويلاقوا أنه ممكن فحص ال one five ag في ال saliva
+
+368
+00:30:48,300 --> 00:30:56,120
+ممكن اللي هو يعكس كمية ال one five ag في الدم
+
+369
+00:30:56,120 --> 00:31:01,040
+وبالتالي يعني ممكن فحص ال one five ag في ال saliva
+
+370
+00:31:02,070 --> 00:31:07,630
+يعني أنا ممكن أكون ل اللي هو ال intermediate زي ما
+
+371
+00:31:07,630 --> 00:31:11,650
+قولنا term of monitoring لكن يمكن هذا بيحتاج يعني
+
+372
+00:31:11,650 --> 00:31:14,630
+إلى more research
+
+373
+00:31:18,410 --> 00:31:22,230
+عندما تتجاوز موارد الجلوكوز تتجاوز موارد الرينال
+
+374
+00:31:22,230 --> 00:31:24,850
+تتجاوز موارد الرينال تتجاوز موارد الرينال تتجاوز
+
+375
+00:31:24,850 --> 00:31:31,970
+موارد الرينال تتجاوز موارد الرينال تتجاوز موارد
+
+376
+00:31:31,970 --> 00:31:38,970
+الرينال تتجاوز موارد الرينال تتجاوز موارد الرينال
+
+377
+00:31:38,970 --> 00:31:39,490
+تتجاوز موارد الرينال تتجاوز موارد الرينال تتجاوز
+
+378
+00:31:39,490 --> 00:31:43,810
+موارد الرينال تتجاوز موارد الرينال تتجاوز موارد
+
+379
+00:31:43,810 --> 00:31:50,610
+الرينال تتجاوز موارد الرينال تتجاوز موو هذا بيؤدى
+
+380
+00:31:50,610 --> 00:31:59,450
+الى انخفاض مستوى ال 1,5 Ag في الدم يبقى اذا كان
+
+381
+00:31:59,450 --> 00:32:06,490
+صار في عندي ارتفاع في ال glucose تمام و اتخطى اللى
+
+382
+00:32:06,490 --> 00:32:13,150
+هو حاجز ال 180 معناته هيصير في عنا نقص في ال
+
+383
+00:32:13,150 --> 00:32:18,010
+reabsorption لل 1,5 Agوهذا هيؤدى الى انخفاض الـ 1
+
+384
+00:32:18,010 --> 00:32:25,430
+,5-AG في الدم يبقى بالتالى low 1,5-AG indicates
+
+385
+00:32:25,430 --> 00:32:30,910
+hyperiglycemia إذا انخفض عندنا مستوى الـ 1,5-AG في
+
+386
+00:32:30,910 --> 00:32:34,830
+الدم معناته هذا بيعنى إن هذا الشخص في عنده
+
+387
+00:32:34,830 --> 00:32:39,730
+hyperiglycemia correlated particularly with
+
+388
+00:32:39,730 --> 00:32:44,090
+postprandial blood glucose concentration
+
+389
+00:32:46,800 --> 00:32:53,920
+في جهاز تم عمله لقياس الـ 15AG Automated
+
+390
+00:32:53,920 --> 00:33:00,120
+Calorimetric Assay وهذا الجهاز approved من الـ FDA
+
+391
+00:33:00,120 --> 00:33:07,200
+اللي يسمى الـ glyco mark يمكن من خلاله نشوف اللي
+
+392
+00:33:07,200 --> 00:33:12,380
+هو ال concentration لـ 15الـ AG وبالتالي انحدد
+
+393
+00:33:12,380 --> 00:33:17,280
+اللي هو مستوى الليجلوكوز عند الشخص زي ما قلنا في
+
+394
+00:33:17,280 --> 00:33:24,460
+اليومين إلى أربعة عشر يوم السابقين ومن
+
+395
+00:33:24,460 --> 00:33:32,290
+خلال دراسة و اللي مقارنة مع ال hemoglobin A1Cيعني
+
+396
+00:33:32,290 --> 00:33:38,630
+تبين إن الـ15AG ممكن يكشف عن بعض اللي هو الحالات
+
+397
+00:33:38,630 --> 00:33:48,990
+اللي فعلياً في عندنا يعني ارتفاع في المستوى لـ
+
+398
+00:33:48,990 --> 00:33:53,770
+Glucose اللي هو Spikes يعني من زي ما قلنا
+
+399
+00:33:53,770 --> 00:33:59,950
+الـAposteprandial عادة Spikes من الـHyperglycemia
+
+400
+00:34:01,330 --> 00:34:04,510
+و هنا في عندنا مثال يعني في عندنا هنا patient
+
+401
+00:34:04,510 --> 00:34:12,550
+fifty year old female و ال hemoglobin A1c فحصوه
+
+402
+00:34:12,550 --> 00:34:20,630
+لجوه سبعة point أربعة بالمية و لما فحصو اللي هو ال
+
+403
+00:34:20,630 --> 00:34:24,990
+one five AG لجوه انه ال concentration اتناش point
+
+404
+00:34:24,990 --> 00:34:29,700
+أربعة micro gram لكل milطبعا هنا ان اللي هو ال
+
+405
+00:34:29,700 --> 00:34:33,060
+interpretation ل ال results من عشر الى واحد و
+
+406
+00:34:33,060 --> 00:34:37,620
+تلاتين يعني يعتبر normal احنا قولنا كل ما إذا كان
+
+407
+00:34:37,620 --> 00:34:40,400
+قل طبعا بيكون فينا hyperglycemia أقل من عشر بيكون
+
+408
+00:34:40,400 --> 00:34:44,960
+فينا اللي هو abnormal glycomark
+
+409
+00:34:47,200 --> 00:34:51,840
+يبقى هان صار فيه كمان متابعة للمرضى يعني على كذا
+
+410
+00:34:51,840 --> 00:34:55,980
+يوم و هان زي ما احنا شايفين انه ال spikes لالـ
+
+411
+00:34:55,980 --> 00:35:01,720
+hyperglycemia يعني قليلة و ال hemoglobin A1C 7.4
+
+412
+00:35:01,720 --> 00:35:08,720
+لكن في عندنا patient آخر 49 سنة old male ال
+
+413
+00:35:08,720 --> 00:35:15,490
+hemoglobin A1C برضه 7.4لكن زي ما احنا شايفين انه
+
+414
+00:35:15,490 --> 00:35:22,350
+كان في عنا repeated lengthy spikes في عنا هدول
+
+415
+00:35:22,350 --> 00:35:26,330
+اللي هو ال spikes لو في عنا ارتفاع يعني زي ما
+
+416
+00:35:26,330 --> 00:35:34,090
+شايفين مرات متكررة لجلوكوز تمام زي ما قلنا ان ال
+
+417
+00:35:34,090 --> 00:35:39,290
+hemoglobin A1c 7.4 يعني مشابه لهذه الحالات لإن
+
+418
+00:35:43,270 --> 00:35:50,350
+اللي كشف الارتفاع هذا المتكرر هو ال glucomarg أو
+
+419
+00:35:50,350 --> 00:35:59,660
+ال 15AG بجهان ال 15AG طلع عندنا 4.5 ميكرو جراميعني
+
+420
+00:35:59,660 --> 00:36:06,140
+ممكن يكون يعني مفيد زي ما قولنا بشكل خاص ل .. اللي
+
+421
+00:36:06,140 --> 00:36:14,680
+هو ال intermediate term لمتابعة المرضى انه أيضا من
+
+422
+00:36:14,680 --> 00:36:20,520
+الفحوصات اللي لابد من عملها برضه يعني بشكل روتيني
+
+423
+00:36:20,520 --> 00:36:26,200
+يعني عادة بتنطلب سنويا
+
+424
+00:36:27,790 --> 00:36:33,610
+اللي هو ال albuminuria لأنه طبعا من ال
+
+425
+00:36:33,610 --> 00:36:37,090
+complications أنه ال microvascular complications
+
+426
+00:36:37,090 --> 00:36:43,290
+أنه يصير فيه nephropathy عند ال patients وبالتالي
+
+427
+00:36:43,290 --> 00:36:50,350
+ممكن هذا يؤدي إلى renal damageوالتجارب اللاجئة
+
+428
+00:36:50,350 --> 00:36:51,330
+اللاجئة اللاجئة اللاجئة اللاجئة اللاجئة اللاجئة
+
+429
+00:36:51,330 --> 00:36:53,210
+اللاجئة اللاجئة اللاجئة اللاجئة اللاجئة اللاجئة
+
+430
+00:36:53,210 --> 00:37:01,090
+اللاجئة اللاجئة اللاجئة اللاجئة اللاجئة اللاجئة
+
+431
+00:37:01,090 --> 00:37:06,030
+اللاجئة اللاجئة اللاجئة اللاجئة اللاجئة اللاجئة
+
+432
+00:37:06,030 --> 00:37:11,630
+اللاجئة اللاجئة اللاجئة اللاجئة اللاجئة اللاجئة
+
+433
+00:37:11,630 --> 00:37:20,870
+اللاجئةهم يعني بالاصل كانوا مرضى سكري تقريبا 60%
+
+434
+00:37:20,870 --> 00:37:25,110
+من ال cases اللي هو with end stage renal disease
+
+435
+00:37:25,110 --> 00:37:32,690
+are patients with type 2 diabetes mellitus يبقى
+
+436
+00:37:32,690 --> 00:37:35,070
+most common cause of end stage renal disease in
+
+437
+00:37:35,070 --> 00:37:37,250
+the United States and Europe برضه اللي هو ال
+
+438
+00:37:37,250 --> 00:37:43,370
+diabetesالتأثير على الـ Macroalbuminuria في الـ
+
+439
+00:37:43,370 --> 00:37:50,930
+Type I تم تصفح كـ 15% إلى 25% والتأثير
+
+440
+00:37:50,930 --> 00:37:56,810
+على الـ Macroalbuminuria تم تصفح كـ 25% إلى 40%
+
+441
+00:37:58,880 --> 00:38:06,560
+طبعاً لما بنحكي micro album نوريا نحكي عن ال
+
+442
+00:38:06,560 --> 00:38:13,280
+urinary albumين اللي هو بيتراوح بين تلاتين إلى
+
+443
+00:38:13,280 --> 00:38:18,060
+تلاتمية ملي اجرام فيه اللي هو اربع عشرين hour
+
+444
+00:38:18,060 --> 00:38:23,760
+urine collectionبينما الماكرو ألبوم نوريا مانت و
+
+445
+00:38:23,760 --> 00:38:28,420
+بنحكي عن ال winner album execution اللي هو أكتر من
+
+446
+00:38:28,420 --> 00:38:33,420
+تلاتمية milligram اللي هو في الاربع و عشرين ساعة
+
+447
+00:38:33,420 --> 00:38:40,100
+في ال type one ال type two diabetes malatus برضه
+
+448
+00:38:40,100 --> 00:38:44,160
+microalbum نوريا occurred in 38 percent of
+
+449
+00:38:44,160 --> 00:38:49,350
+participants in a cohort studyيبقى ال type one و
+
+450
+00:38:49,350 --> 00:38:53,730
+ال type two طبعا يعني من ال complications انه يصير
+
+451
+00:38:53,730 --> 00:38:59,170
+في عنا اللي هو micro albumuria و اللي ممكن تتطور
+
+452
+00:38:59,170 --> 00:39:02,090
+ليه برضه macro albumuria
+
+453
+00:39:04,610 --> 00:39:08,370
+التحقق الـ diabetic nephropathy يعتمد على تجارب
+
+454
+00:39:08,370 --> 00:39:10,650
+تجارب ألبومية يتم تجارب ألبومية يتم تجارب ألبومية
+
+455
+00:39:10,650 --> 00:39:13,110
+يتم تجارب ألبومية يتم تجارب ألبومية يتم تجارب
+
+456
+00:39:13,110 --> 00:39:15,890
+ألبومية يتم تجارب ألبومية يتم تجارب ألبومية يتم
+
+457
+00:39:15,890 --> 00:39:19,850
+تجارب ألبومية يتم تجارب ألبومية يتم تجارب ألبومية
+
+458
+00:39:19,850 --> 00:39:20,590
+يتم تجارب ألبومية يتم تجارب ألبومية يتم تجارب
+
+459
+00:39:20,590 --> 00:39:20,630
+ألبومية يتم تجارب ألبومية يتم تجارب ألبومية يتم
+
+460
+00:39:20,630 --> 00:39:21,610
+تجارب ألبومية يتم تجارب ألبومية يتم تجارب ألبومية
+
+461
+00:39:21,610 --> 00:39:25,070
+يتم تجارب ألبومية يتم تجارالـ kidney و بنشوف إذا
+
+462
+00:39:25,070 --> 00:39:31,070
+في عندنا يعني بدأت ال .. ممكن ال nephropathy أو
+
+463
+00:39:31,070 --> 00:39:35,730
+بدأ يصير في عندنا خلل في ال kidney Persistent
+
+464
+00:39:35,730 --> 00:39:38,930
+proteinuria detectable by routine screening
+
+465
+00:39:43,120 --> 00:39:46,260
+الـ Persistent اللي هو proteinuria أو اللي هو
+
+466
+00:39:46,260 --> 00:39:49,640
+سبناها ال macro proteinuria detectable by routine
+
+467
+00:39:49,640 --> 00:39:54,020
+screening test الألبومين اللي هو execution rate
+
+468
+00:39:54,020 --> 00:39:57,360
+أكتر من 200 ميكرو جرام لكل minute أو اللي هو أكتر
+
+469
+00:39:57,360 --> 00:40:03,900
+من 300 ميلي جرام زي ما حكينا في ال 24 hours طبعا
+
+470
+00:40:03,900 --> 00:40:06,660
+إذا كان في عندنا persistent proteinuria أو اللي هو
+
+471
+00:40:06,660 --> 00:40:12,620
+macroاللي هو ألبوم نوريا معناته هذا بيوحي أنه
+
+472
+00:40:12,620 --> 00:40:15,820
+فيانا overt diabetic nephropathy
+
+473
+00:40:18,000 --> 00:40:20,720
+طبعا هذا يعني من ال .. أكيد اللي هو الـ long term
+
+474
+00:40:20,720 --> 00:40:24,300
+complications associated with long standing
+
+475
+00:40:24,300 --> 00:40:29,220
+disease. Once diabetic nephropathy occurs, renal
+
+476
+00:40:29,220 --> 00:40:33,260
+function deteriorates rapidly and renal
+
+477
+00:40:33,260 --> 00:40:38,220
+insufficiency evolves وطبعا ممكن ينتهي المريض بيه
+
+478
+00:40:38,220 --> 00:40:42,040
+اللي هو end stage renal disease و renal failure
+
+479
+00:40:42,920 --> 00:40:46,360
+Treatment at this stage can retard the rate of
+
+480
+00:40:46,360 --> 00:40:50,240
+percolation without stopping or reversing the
+
+481
+00:40:50,240 --> 00:40:56,320
+renal damage عشان
+
+482
+00:40:56,320 --> 00:41:05,020
+هيك طبعا لي المتابعة مهمةيعني أنه نكشف عن وجود ال
+
+483
+00:41:05,020 --> 00:41:08,000
+.. ال .. ال album نوريا أو زي ما قلنا كانت يعني
+
+484
+00:41:08,000 --> 00:41:12,460
+تسمى سابق ال micro album نوريا وبالتالي يعني ممكن
+
+485
+00:41:12,460 --> 00:41:18,520
+يكون فيه فرصة للتدخل ومنع حدوث ال .. ال renal
+
+486
+00:41:18,520 --> 00:41:19,640
+failure
+
+487
+00:41:22,040 --> 00:41:24,860
+يبقى preceding this stage اللي جاب لمرحلة الـ
+
+488
+00:41:24,860 --> 00:41:28,200
+Macroalbuminuria فيه أنه مرحلة of increased
+
+489
+00:41:28,200 --> 00:41:32,720
+albumin execution rate not detected by routine
+
+490
+00:41:32,720 --> 00:41:36,720
+dipstick methods يبقى بالطريقة اللي هو العادية
+
+491
+00:41:36,720 --> 00:41:40,560
+اللي بنفحص فيها ال protein و ال dipstick مش ممكن
+
+492
+00:41:40,560 --> 00:41:45,140
+أنه نقدر نعمل detection لهذه الكميات القليلة من
+
+493
+00:41:45,530 --> 00:41:48,430
+الألبوم اللي يتراوح بين عشرين إلى متين microgram
+
+494
+00:41:48,430 --> 00:41:52,270
+في ال minute أو تلاتين إلى تلاتمائة milligram لكل
+
+495
+00:41:52,270 --> 00:41:57,090
+اللي هو أربع وعشرين ساعة تمام و هذه المرحلة اللي
+
+496
+00:41:57,090 --> 00:42:02,610
+قلنا microalbuminuria أو albuminuria current
+
+497
+00:42:02,610 --> 00:42:04,490
+nomenclature has eliminated the term
+
+498
+00:42:04,490 --> 00:42:09,750
+microalbuminuriaان macro albumuria يعني الآن لأنه
+
+499
+00:42:09,750 --> 00:42:14,610
+يعني ممكن تفهم خطأ اللي هي micro albumuria تمام
+
+500
+00:42:14,610 --> 00:42:17,330
+انه بنحكي يعني عن album اللي هو ممكن يكون يعني
+
+501
+00:42:17,330 --> 00:42:22,790
+micro او يعني صغير واستبدلوه بال albumuria لكن
+
+502
+00:42:22,790 --> 00:42:26,110
+لغاية الآن يعني ناس كتير بتستخدم اللي هو ال micro
+
+503
+00:42:26,110 --> 00:42:29,010
+albumuria و ال macro albumuria
+
+504
+00:42:31,210 --> 00:42:33,510
+تمام يبقى السبب زي ما قلنا ان ال macro albumuria
+
+505
+00:42:33,510 --> 00:42:37,850
+يعني ممكن يكون misleading اه يعني ما يتبش فاهم
+
+506
+00:42:37,850 --> 00:42:42,310
+المصطلح بشكل الصحيح implies a small version of the
+
+507
+00:42:42,310 --> 00:42:45,970
+album molecule rather than an excretion rate of
+
+508
+00:42:45,970 --> 00:42:49,590
+album greater than normal but less than detectable
+
+509
+00:42:49,590 --> 00:42:53,570
+by routine methods يبقى ممكن نفهم ان micro معناته
+
+510
+00:42:53,570 --> 00:42:57,910
+ان في عندنا يعني زي نسخة لكن اللي هي أصغر ممكن من
+
+511
+00:42:57,910 --> 00:43:03,180
+ال album الطبيعيوبتاع علشان هيك اللي هو ال micro
+
+512
+00:43:03,180 --> 00:43:07,240
+albumuria يعني لا يحبة استخدام هذا المصطرح لكن
+
+513
+00:43:07,240 --> 00:43:12,180
+احنا الدارج اللي اللي فعليا بيستخدم هو ال micro
+
+514
+00:43:12,180 --> 00:43:18,020
+albumuria طبعا
+
+515
+00:43:18,020 --> 00:43:27,180
+المشكلة هان انه بيصير في عندنا مرور لال album عبر
+
+516
+00:43:28,810 --> 00:43:32,310
+الـ glomerulus هالي عبارة عن tuft of capillaries
+
+517
+00:43:32,310 --> 00:43:35,830
+زي ما انتوا عارفين و اللي من خلالها بيصير عملية ال
+
+518
+00:43:35,830 --> 00:43:44,710
+wall filtration لل blood و في عندنا طبعا يعني اللي
+
+519
+00:43:44,710 --> 00:43:51,610
+هي ال proteinات اللي molecular weight أقل
+
+520
+00:43:51,610 --> 00:43:51,890
+من
+
+521
+00:43:54,810 --> 00:44:01,290
+تقريبا ستين كيلو تلتن، يبقى ال .. إذا كان أكبر من
+
+522
+00:44:01,290 --> 00:44:05,430
+ستين كيلو تلتن يبقى بيسلهوش فيلتريش يفضل موجود
+
+523
+00:44:05,430 --> 00:44:09,050
+بالدم، إذا أقل ممكن يسلهو filtration، الآن بيصير
+
+524
+00:44:09,050 --> 00:44:15,290
+فينا مشكلةفي ال ال pores الموجودة في ال
+
+525
+00:44:15,290 --> 00:44:21,790
+capillaries وبالتالي هذا بيسمح بمرور اللي هو
+
+526
+00:44:21,790 --> 00:44:26,290
+proteins اللي ال molecular weight بتاعتها أكبر من
+
+527
+00:44:26,290 --> 00:44:31,310
+ستين kilo Dalton اللي هو زي ال album و بالتالي
+
+528
+00:44:31,310 --> 00:44:37,710
+بنلاقي أنه بدأ يصير فينا concentration أعلى من هذه
+
+529
+00:44:37,710 --> 00:44:44,590
+ال proteins في ال urineيبقى متابعتنا لكميات
+
+530
+00:44:44,590 --> 00:44:49,610
+الألبومين اللي بتسلق execution في ال urine بتعطي
+
+531
+00:44:49,610 --> 00:44:55,070
+indication عن حالةالـ microvessels في الكدن
+
+532
+00:44:55,070 --> 00:45:00,130
+وبالتالي الـ risk للإصابة بالـ diabetic
+
+533
+00:45:00,130 --> 00:45:04,310
+nephropathy أو يعني مستقبلا بالـ end-stage renal
+
+534
+00:45:04,310 --> 00:45:08,250
+disease يبقى persistent album in execution rate
+
+535
+00:45:08,250 --> 00:45:12,410
+greater than 20 microgram per minute represents a
+
+536
+00:45:12,410 --> 00:45:16,330
+twenty-fold greater risk for the development of
+
+537
+00:45:16,330 --> 00:45:22,260
+clinically overt renal diseaseوإذا كان إن الـ
+
+538
+00:45:22,260 --> 00:45:25,920
+execution أعلى من عشرين microgram بالدقيقة، يبقى
+
+539
+00:45:25,920 --> 00:45:31,780
+معناته الشخص هذا عنده ال risk عشرين مرة أكتر
+
+540
+00:45:31,780 --> 00:45:36,880
+للإصابة بالـ kidney disease و بال patients في
+
+541
+00:45:36,880 --> 00:45:44,460
+الtype 1 أو الtype 2وبرضه العديد من الدراسات أكدت
+
+542
+00:45:44,460 --> 00:45:48,240
+هذا الكلام وأكدت إن الـ Increased urinary album
+
+543
+00:45:48,240 --> 00:45:50,840
+execution in patients with diabetes mellitus
+
+544
+00:45:50,840 --> 00:45:54,060
+precedes and is highly predictive of diabetic
+
+545
+00:45:54,060 --> 00:45:56,800
+nephropathy, end-stage renal disease,
+
+546
+00:45:57,400 --> 00:46:02,280
+cardiovascular mortality و الـ total mortality
+
+547
+00:46:02,280 --> 00:46:03,580
+بشكل عام
+
+548
+00:46:06,170 --> 00:46:13,290
+والبتابعة مهمة لأنه فعليًا إذا كان تم الكشف
+
+549
+00:46:13,290 --> 00:46:22,650
+عن الـ Albuminuria يبقى التدخل العلاجي ممكن يقلل
+
+550
+00:46:22,650 --> 00:46:26,730
+من احتمالية إصابة الشخص مستقبلا بـ Kidney Disease
+
+551
+00:46:26,730 --> 00:46:33,750
+وهذا من خلال دراستيناللي هو باسمها DCCT و UKPDS
+
+552
+00:46:33,750 --> 00:46:37,910
+هدول الدراستين لاجوا إنه intensive diabetes
+
+553
+00:46:37,910 --> 00:46:41,470
+therapy can significantly reduce the risk of
+
+554
+00:46:41,470 --> 00:46:45,230
+development of increased albumin excretion rate
+
+555
+00:46:45,230 --> 00:46:48,290
+and overt nephropathy in individuals with diabetes
+
+556
+00:46:48,290 --> 00:46:58,730
+يبقى التدخل ممكن فعليًا يقلل من اللي هو يعنيالـ
+
+557
+00:46:58,730 --> 00:47:03,910
+Nephropathy أو الإصابة بالـ Renal Disease يعشان
+
+558
+00:47:03,910 --> 00:47:09,810
+هيك المتابعة لمستويات ال album بال urine مهمة
+
+559
+00:47:12,210 --> 00:47:17,870
+برضه اللي هو الزيادة في ال execution لـ ال albumin
+
+560
+00:47:17,870 --> 00:47:24,850
+بالـ urine برضه مرتبط بالـ cardiovascular diseases
+
+561
+00:47:24,850 --> 00:47:28,770
+برضه و زيادة في ال albumin execution rate
+
+562
+00:47:28,770 --> 00:47:32,950
+identifies a group of non-diabetic subjects at
+
+563
+00:47:32,950 --> 00:47:39,830
+increased risk for coronary artery disease وكمان
+
+564
+00:47:39,830 --> 00:47:44,050
+حتى عنداللي هو الناس ممكن اللي مش مصابين
+
+565
+00:47:44,050 --> 00:47:52,570
+بالديابتاس ممكن استخدام هذا الفحص لمعرفة خطر
+
+566
+00:47:52,570 --> 00:47:57,110
+إصابتهم بالـ Coronary Artery Disease من الـ
+
+567
+00:47:57,110 --> 00:47:59,930
+interventions ال control of blood glucose
+
+568
+00:47:59,930 --> 00:48:05,250
+concentration و blood pressure particularly with
+
+569
+00:48:05,250 --> 00:48:09,860
+angiotensin converting enzyme inhibitorsعشان اللي
+
+570
+00:48:09,860 --> 00:48:15,660
+هي من مخفضة طبعا أدوية المخفضة ليه الضغط Slow the
+
+571
+00:48:15,660 --> 00:48:22,580
+rate of decline in renal function وهنا
+
+572
+00:48:22,580 --> 00:48:25,920
+اللي هو نتائج الدراستين اللي حكينا عليهم اللي هو
+
+573
+00:48:25,920 --> 00:48:31,720
+ال DCCT و ال UKBDS و في دراسة أخرى أيضا Komamoto
+
+574
+00:48:33,340 --> 00:48:36,500
+التخفيض الـ hemoglobin A1C يعني هان في هذه الدراسة
+
+575
+00:48:36,500 --> 00:48:40,840
+الأولى من 9 على 7.2 قلل ال incidence of
+
+576
+00:48:40,840 --> 00:48:44,180
+complications للـ retinopathy بنسبة 63% نفروباثي
+
+577
+00:48:44,180 --> 00:48:48,740
+بنسبة 54% نيوروباثي بنسبة 60% و ال cardiovascular
+
+578
+00:48:48,740 --> 00:48:54,380
+disease بنسبة 41% دراسة تانية قللوا ال hemoglobin
+
+579
+00:48:54,380 --> 00:48:58,520
+A1C من 9 إلى 7 برضه هذا قلل من ال complications
+
+580
+00:48:58,520 --> 00:49:04,700
+بالرتينوباثي و النفروباثي و أيضا حسنمن اللي هو
+
+581
+00:49:04,700 --> 00:49:11,940
+يعني عمل اللي هو الأعصاب أو ال neurons و الدراسة
+
+582
+00:49:11,940 --> 00:49:16,820
+التالتة قللوا ال hemoglobin ONC من تمانية إلى سبعة
+
+583
+00:49:16,820 --> 00:49:21,940
+وهذا برضه قلل من ال incidence ل ال complications
+
+584
+00:49:21,940 --> 00:49:25,680
+زي الwaritinopathy و ال nephropathy و أيضا ال
+
+585
+00:49:25,680 --> 00:49:28,440
+cardiovascular disease
+
+586
+00:49:31,150 --> 00:49:34,870
+هيك منكن ان نتهينا من اللي هي محاضرة ال debitas
+
+587
+00:49:34,870 --> 00:49:39,710
+maletas الجزئين و بيضل عندنا ال case studies اللي
+
+588
+00:49:39,710 --> 00:49:46,350
+هنشوف ان شاء الله في اللقاء الوجاهي و يعطيكوا الف
+
+589
+00:49:46,350 --> 00:49:46,910
+عافية
+
diff --git a/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/yK1u3cVlgj0.srt b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/yK1u3cVlgj0.srt
new file mode 100644
index 0000000000000000000000000000000000000000..a35ea603828b190f6d26329ffc47a0f83ca8dfd9
--- /dev/null
+++ b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/yK1u3cVlgj0.srt
@@ -0,0 +1,728 @@
+1
+00:00:01,310 --> 00:00:05,770
+بسم الله الرحمن الرحيم نستكمل مع محاضرة ال
+
+2
+00:00:05,770 --> 00:00:13,110
+diabetes mellitus، والمحاضرة الثانية. بداية بدنا
+
+3
+00:00:13,110 --> 00:00:20,550
+نحكي عن الـ diagnosis، والقطعة الأولى ستتعلق بـ Pre
+
+4
+00:00:20,550 --> 00:00:25,830
+-clinical diagnosis أو الـ Screening، اللي هو
+
+5
+00:00:25,830 --> 00:00:32,390
+الفحوصات التي يمكن أن نجريها، وطبعًا على يعني ال...
+
+6
+00:00:32,390 --> 00:00:38,410
+المرضى المتوقع أن يصابوا، و
+
+7
+00:00:40,010 --> 00:00:47,490
+يعني يكون في عندنا تدخل علاجي لمنع أو تأخير حدوث
+
+8
+00:00:47,490 --> 00:00:50,670
+المرض. طبعًا الـ preclinical معناه أننا نعني
+
+9
+00:00:50,670 --> 00:00:55,330
+patients، أو يعني بنعني أشخاصًا لم تظهر عليهم الأعراض symptoms لسة
+
+10
+00:00:55,330 --> 00:00:59,380
+مظهرتش عليهم تمامًا. يبقى pre-clinical أو اللي هو
+
+11
+00:00:59,380 --> 00:01:03,520
+بنحكي screening. الـ screening أيضًا نفس الفكرة أنه
+
+12
+00:01:03,520 --> 00:01:09,340
+نعمل فحص لشخص لم تظهر عليه الأعراض symptoms، لنرى
+
+13
+00:01:09,340 --> 00:01:16,800
+إذا كان لديه مرض معين أم لا. طبعًا الـ... الـ
+
+14
+00:01:16,800 --> 00:01:22,600
+... الـ screening يكون مفيدًا في حال وجود
+
+15
+00:01:22,600 --> 00:01:28,030
+علاج. طبعًا، يبقى إذا كان هناك علاج، معناه أن
+
+16
+00:01:28,030 --> 00:01:34,510
+الـ screening  ممكن أن تكون مفيدة. الآن، فيما يتعلق
+
+17
+00:01:34,510 --> 00:01:39,230
+بـ animal studies،  يبقى صار فيه تجارب على الـ
+
+18
+00:01:39,230 --> 00:01:45,550
+animals، ووجدوا أنهم يعملوا immune intervention
+
+19
+00:01:45,550 --> 00:01:54,250
+therapy. بيقدروا يدخلوا، ومن خلال هذا التدخل يعني
+
+20
+00:01:54,250 --> 00:01:57,830
+كان هناك delay أو prevention لحدوث الـ type 1
+
+21
+00:01:57,830 --> 00:02:01,870
+diabetes. malnutrition and هذه الحيوانات
+
+22
+00:02:05,350 --> 00:02:09,890
+الآن، الدراسات التي أجريت على الإنسان، للأسف يعني
+
+23
+00:02:09,890 --> 00:02:14,590
+كانت disappointing، يعني لم تنجح، أي العلاجات
+
+24
+00:02:14,590 --> 00:02:20,790
+كما نجحت عند الحيوانات، لكن مع ذلك يعني يظل
+
+25
+00:02:20,790 --> 00:02:26,670
+الأمل موجودًا، وما زال هناك العديد من الدراسات، والتي هي
+
+26
+00:02:26,670 --> 00:02:31,450
+في عندنا large clinical trials، يعني شغالة. وهذه الـ
+
+27
+00:02:31,450 --> 00:02:37,790
+clinical trials تحاول أن تجد الـ therapeutic
+
+28
+00:02:37,790 --> 00:02:42,170
+strategies لتأخير
+
+29
+00:02:42,170 --> 00:02:47,890
+أو لمنع حدوث الـ type 1 diabetes mellitus. يبقى مثلًا
+
+30
+00:02:47,890 --> 00:02:55,390
+لغاية الآن، لا يوجد لدينا طريقة علاجية، لا يوجد لدينا لو
+
+31
+00:02:55,390 --> 00:03:02,610
+تدخل علاجي يمكن أن يؤخر أو يمنع حدوث الـ type 1
+
+32
+00:03:02,610 --> 00:03:08,910
+diabetes mellitus. يبقى بالتالي أن نعمل screening
+
+33
+00:03:08,910 --> 00:03:15,910
+للـ antibodies ليس موصى به. طبعًا أن الـ
+
+34
+00:03:15,910 --> 00:03:21,990
+... الـ... المرضى، اللي هو الـ... الذين يمكن يعني متوقع
+
+35
+00:03:21,990 --> 00:03:26,430
+أن يصابوا. إذا كان لديهم في العائلة،  ممكن أن يكون هناك ناس
+
+36
+00:03:26,430 --> 00:03:32,230
+مصابة، ونجيء، ونقعد نفحص لهؤلاء المرضى، ونرى إذا
+
+37
+00:03:32,230 --> 00:03:36,670
+كان لديهم antibodies من التي ذكرناها سابقًا، هذا
+
+38
+00:03:36,670 --> 00:03:42,150
+الموضوع ليس موصى به طبعًا. يبقى ممكن أن يصير في
+
+39
+00:03:42,150 --> 00:03:46,950
+حال أن هؤلاء كانوا يمكن يعني يشاركون في
+
+40
+00:03:46,950 --> 00:03:54,770
+clinical studies، لكن  لعمل screening وتحديد أن
+
+41
+00:03:54,770 --> 00:03:58,390
+هذا المريض سيصاب أو لن يصاب، يعني ليس
+
+42
+00:03:58,390 --> 00:04:01,550
+موصى به، لأن كما قلنا لغاية الآن ليس لدينا
+
+43
+00:04:01,550 --> 00:04:05,870
+يعني تدخل علاجي، وبالتالي، ما الفائدة؟
+
+44
+00:04:08,210 --> 00:04:12,930
+أن نقول للشخص: والله، أنت يعني احتمال كبير أنك تصاب
+
+45
+00:04:12,930 --> 00:04:20,230
+أم لا. فيما يتعلق بالـ screening لـ type 2 diabetes
+
+46
+00:04:20,230 --> 00:04:20,790
+mellitus
+
+47
+00:04:23,610 --> 00:04:27,530
+التوصيات من قبل الـ American Diabetes Association
+
+48
+00:04:27,530 --> 00:04:36,970
+سابقًا كانت توصي بعدم فحص الناس الذين هم at
+
+49
+00:04:36,970 --> 00:04:41,550
+higher risk للإصابة بـ type 2 diabetes mellitus،
+
+50
+00:04:41,550 --> 00:04:45,610
+لكن
+
+51
+00:04:45,610 --> 00:04:54,870
+الآن، أي الـ ADA تنصح أن يكون هناك screening لـ
+
+52
+00:04:54,870 --> 00:04:58,730
+All asymptomatic individuals over the age of 45
+
+53
+00:04:58,730 --> 00:05:04,350
+years. يبقى كل الأشخاص فوق الخمسة والأربعين، تنصح الـ
+
+54
+00:05:04,350 --> 00:05:09,370
+American Diabetes Association أن يعملوا فحصًا لـ
+
+55
+00:05:09,370 --> 00:05:15,540
+glucose concentration. الخطوات الحالية تتضمن استخدام
+
+56
+00:05:15,540 --> 00:05:29,040
+Hemoglobin A1C  للتسجيل. إذا كان
+
+57
+00:05:29,040 --> 00:05:36,070
+Hemoglobin A1C أقل من 5.7%، أو في عندنا وحدات أخرى
+
+58
+00:05:36,070 --> 00:05:40,370
+وهي الـ hemoglobin A1C، وهي ملي مول لكل مول
+
+59
+00:05:40,370 --> 00:05:44,890
+ملي مول من الـ hemoglobin A1C لكل مول من
+
+60
+00:05:44,890 --> 00:05:47,950
+الـ hemoglobin، اللي هو تسعة وثلاثون، يعني خمسة
+
+61
+00:05:47,950 --> 00:05:55,270
+point سبعة، أو تسعة وثلاثون، أو الـ fasting plasma
+
+62
+00:05:55,270 --> 00:05:57,790
+glucose less than one hundred milligram per
+
+63
+00:05:57,790 --> 00:06:01,290
+deciliter. testing should be repeated at three
+
+64
+00:06:01,290 --> 00:06:06,110
+years interval. إذا كانت النتيجة التي طلعت للـ hemoglobin
+
+65
+00:06:06,110 --> 00:06:11,850
+A1C اللي هو أقل من 5.7، أو الـ fasting plasma
+
+66
+00:06:11,850 --> 00:06:19,290
+glucose أقل من 100، يبقى ممكن هذا الشخص يعمل الـ
+
+67
+00:06:19,290 --> 00:06:22,770
+glucose concentration، أو اللي هو يعني الـ
+
+68
+00:06:22,770 --> 00:06:31,090
+hemoglobin A1C كل ثلاث سنوات. الآن الأمر يختلف إذا كان
+
+69
+00:06:31,090 --> 00:06:38,840
+أن الشخص هذا لديه risk factors. يبقى الـ... الـ
+
+70
+00:06:38,840 --> 00:06:42,660
+testing may be considered at a younger age. يبقى لن
+
+71
+00:06:42,660 --> 00:06:50,220
+ننتظر عمر 45، لكي يصير في عندنا يعني routine
+
+72
+00:06:50,220 --> 00:06:53,720
+أي قياس، أو frequent measurement للـ...
+
+73
+00:06:53,720 --> 00:06:57,500
+glucose في الدم. يبقى إذا كان لدينا risk factors
+
+74
+00:06:57,500 --> 00:07:02,940
+موجودة، يبقى المفروض أن نبدأ at a younger age.
+
+75
+00:07:04,570 --> 00:07:10,370
+ويبدو أنه يكون في عندنا يعني الفحص هذا more frequent.
+
+76
+00:07:10,370 --> 00:07:13,910
+وطبعًا، كما تعلمون، من الـ risk factors أنه
+
+77
+00:07:13,910 --> 00:07:17,350
+يكون في عندنا family history، يكون هناك أشخاص مصابون
+
+78
+00:07:17,350 --> 00:07:22,090
+أي من أقارب الدرجة الأولى first degree relatives مصابون، أو يكون هناك
+
+79
+00:07:22,090 --> 00:07:24,930
+أي certain ethnic groups.
+
+80
+00:07:26,700 --> 00:07:31,200
+أيضًا هؤلاء أكثر عرضة، مثل الـ black، أكثر عرضة
+
+81
+00:07:31,200 --> 00:07:36,320
+للإصابة بـ type 2 diabetes mellitus، أو يكون مثلاً
+
+82
+00:07:36,320 --> 00:07:40,960
+obese. طبعًا، كل هذه risk factors، وبالتالي هذه كلها
+
+83
+00:07:40,960 --> 00:07:46,560
+تستدعي أن يكون هناك، أي أن لا نصل لسن خمسة
+
+84
+00:07:46,560 --> 00:07:53,260
+وأربعين، ممكن من سن مبكرة، وممكن في بعض
+
+85
+00:07:53,260 --> 00:08:03,060
+الأحيان أن يكون لدينا فحص بشكل مستمر للأطفال
+
+86
+00:08:03,060 --> 00:08:10,700
+حتى، إذا كان هناك أكثر من risk factor موجود.
+
+87
+00:08:13,630 --> 00:08:19,090
+وعشان هيك، مع ارتفاع عدد الأشخاص المصابين
+
+88
+00:08:19,090 --> 00:08:26,630
+بـ type 2 diabetes mellitus عند المراهقين، أصبح هناك
+
+89
+00:08:26,630 --> 00:08:34,690
+توصيات بأن يكون هناك screening للـ overweight youth.
+
+90
+00:08:36,270 --> 00:08:38,950
+يعني حتى عند المراهقين أو الشباب،
+
+91
+00:08:38,950 --> 00:08:48,130
+يكون هناك screening في حال كونهم obese، أي أن
+
+92
+00:08:48,130 --> 00:08:52,330
+body mass index أكثر من eighty five
+
+93
+00:08:52,330 --> 00:08:53,230
+percentile.
+
+94
+00:08:57,280 --> 00:09:06,180
+كما هو واضح، لدينا طبعًا اللي هو فيه الـ...
+
+95
+00:09:06,180 --> 00:09:11,080
+الـ healthy weight،  من خمسة إلى خمسة وثمانين، من خمسة وثمانين إلى خمسة و
+
+96
+00:09:11,080 --> 00:09:18,980
+تسعين، لدينا overweight، ولدينا اللي هو الـ 95 و
+
+97
+00:09:18,980 --> 00:09:27,140
+أعلى، اللي هو الـ obese. يبقى
+
+98
+00:09:33,100 --> 00:09:37,680
+الشباب أو المراهقين، إذا كان body mass index
+
+99
+00:09:37,680 --> 00:09:40,400
+الذي هو أكثر من 85،
+
+100
+00:09:43,280 --> 00:09:50,480
+مع وجود two risk factors. يبقى الشرط الأول أن يكون
+
+101
+00:09:50,480 --> 00:09:55,620
+overweight، تمامًا، with any two of the following risk
+
+102
+00:09:55,620 --> 00:09:59,900
+factors. مع اثنين من عوامل الخطر التالية. يبقى
+
+103
+00:09:59,900 --> 00:10:05,620
+في هذه الحالة، ينصح أن يكون هناك screening ومتابعة
+
+104
+00:10:05,620 --> 00:10:09,010
+مستمرة لهؤلاء الأشخاص. ما هي عوامل الخطر؟ they have
+
+105
+00:10:09,010 --> 00:10:12,010
+family history of type 2 diabetes mellitus in first
+
+106
+00:10:12,010 --> 00:10:16,230
+or second degree relatives. they belong to a
+
+107
+00:10:16,230 --> 00:10:22,030
+certain race or ethnic group.  كما قلنا،
+
+108
+00:10:22,030 --> 00:10:28,850
+لدينا الـ black،  كمثال، أكثر عرضة للإصابة
+
+109
+00:10:28,850 --> 00:10:32,530
+بـ type 2 diabetes mellitus. they have signs of
+
+110
+00:10:32,530 --> 00:10:36,990
+insulin resistance or conditions associated with
+
+111
+00:10:36,990 --> 00:10:40,610
+insulin resistance. مثل الحالات التي
+
+112
+00:10:40,610 --> 00:10:45,250
+ذكرناها سابقًا، وقلنا أنها تكون لدى الأشخاص الذين لديهم
+
+113
+00:10:45,250 --> 00:10:49,010
+insulin resistance، أو أن يكون هناك maternal
+
+114
+00:10:49,010 --> 00:10:52,050
+history of diabetes or gestational diabetes
+
+115
+00:10:52,050 --> 00:10:56,770
+mellitus during the child's gestation. أن يكون عند
+
+116
+00:10:56,770 --> 00:11:00,230
+الأم  gestational diabetes mellitus خلال
+
+117
+00:11:00,230 --> 00:11:06,360
+حملها بهذا الطفل. تمامًا. يبقى overweight مع
+
+118
+00:11:06,360 --> 00:11:10,080
+two risk factors من التي ذكرناها، يبقى هذا
+
+119
+00:11:10,080 --> 00:11:16,120
+يستدعي أن يكون هناك screening حتى للأطفال
+
+120
+00:11:16,120 --> 00:11:23,240
+الذين هم overweight. testing should be done every
+
+121
+00:11:23,240 --> 00:11:29,850
+three years starting at 10 years of age. طيب، الآن
+
+122
+00:11:29,850 --> 00:11:33,210
+ما هو الاختلاف؟ يعني الـ... الـ type 2 diabetes
+
+123
+00:11:33,210 --> 00:11:39,550
+mellitus أيضًا، لغاية الآن، لا يوجد علاج، يعني لا يوجد علاج
+
+124
+00:11:39,550 --> 00:11:44,240
+لشخص يشفى تمامًا؟ كما قلنا في type 1 diabetes
+
+125
+00:11:44,240 --> 00:11:47,900
+mellitus.  طيب، لماذا في type 1 diabetes mellitus؟ لأنه
+
+126
+00:11:47,900 --> 00:11:52,320
+ليس موصى به أن نعمل screening للأجسام المضادة antibodies، لكن هنا نقول أنه  it is recommended
+
+127
+00:11:55,940 --> 00:12:01,520
+أن نعمل فحصًا للجلوكوز، ونرى من الأشخاص الذين يعني
+
+128
+00:12:01,520 --> 00:12:07,420
+ممكن أن يصابوا. الفرق هنا بين الحالة الأولى و
+
+129
+00:12:07,420 --> 00:12:13,870
+الحالة الثانية، أنه لدينا عدد ليس بسيطًا، تقريبًا
+
+130
+00:12:13,870 --> 00:12:20,390
+ثلاثة وثلاثون بالمئة من الأشخاص الذين لديهم بالفعل
+
+131
+00:12:20,390 --> 00:12:24,670
+type 2 diabetes mellitus، هؤلاء يكونون undiagnosed.
+
+132
+00:12:24,670 --> 00:12:29,290
+وإذا تذكرون عندما تحدثنا عن النسب في البداية، ذكرنا
+
+133
+00:12:29,290 --> 00:12:35,190
+الأعداد التي سجلت رسميًا، وكان هناك عدد من هؤلاء يعتبر undiagnosed، يعني هم لديهم
+
+134
+00:12:35,190 --> 00:12:40,350
+type 2 diabetes mellitus، لكن لم يتم تشخيصهم.
+
+135
+00:12:40,350 --> 00:12:44,410
+وبالتالي، هنا، لأن النسبة ليست بسيطة من
+
+136
+00:12:44,410 --> 00:12:50,760
+الأشخاص لديهم type 2 diabetes mellitus، و
+
+137
+00:12:50,760 --> 00:12:54,180
+يقضون فترة مصابين، وارتفاع محتمل في السكر
+
+138
+00:12:54,180 --> 00:12:59,120
+في الدم، لكن undiagnosed. وبالتالي، طوال هذه الفترة، يكون هناك
+
+139
+00:12:59,120 --> 00:13:04,790
+ارتفاع في السكر بدون أي تدخل، بدون أي علاج،
+
+140
+00:13:04,790 --> 00:13:10,270
+وبالتالي، يمكن أن تظهر المضاعفات complications، أي أن حالات
+
+141
+00:13:10,270 --> 00:13:16,430
+كثيرة، عندما يتم تشخيصها بأنها مصابة بـ type 2 diabetes
+
+142
+00:13:16,430 --> 00:13:20,130
+mellitus، تكون قد بدأت بالفعل، أو بدأت لديهم
+
+143
+00:13:20,130 --> 00:13:25,310
+المضاعفات complications. طبعًا، لهذا السبب،  طبعًا
+
+144
+00:13:25,310 --> 00:13:30,880
+نصحوا بأن يكون لدينا screening  للذين هم فوق
+
+145
+00:13:30,880 --> 00:13:36,480
+سن الـ 45، أو كما قلنا at a younger age
+
+146
+00:13:36,480 --> 00:13:40,360
+للناس الذين لديهم high risk factors، لكي إذا
+
+147
+00:13:40,360 --> 00:13:49,420
+لديهم، أو ظهر لديهم سكري، يتم اكتشاف الحالة مبكرًا،
+
+148
+00:13:49,420 --> 00:13:54,660
+وبالتالي، يكون هناك تدخل علاجي، طبعًا مع
+
+149
+00:13:54,660 --> 00:13:59,840
+الأمور الأخرى، مثل إنقاص الوزن، والرياضة، وخلافه،
+
+150
+00:13:59,840 --> 00:14:03,000
+وبالتالي، نبتعد عن حدوث الـ complications.
+
+151
+00:14:13,200 --> 00:14:15,440
+في عملية تجارب، تجارب، تجارب، عملية تجارب، عملية تجارب،
+
+152
+00:14:15,440 --> 00:14:21,380
+عملية تجارب، عملية تجارب، عملية تجارب، عملية تجارب،
+
+153
+00:14:21,380 --> 00:14:26,800
+عملية تجارب، عملية تجارب، عملية تجارب، عملية تجارب،
+
+154
+00:14:26,800 --> 00:14:28,880
+عملية تجارب، عملية تجارب، عملية تجارب، عملية تجارب،
+
+155
+00:14:28,880 --> 00:14:29,000
+عملية تجارب، عملية تجارب، عملية تجارب، عملية تجارب،
+
+156
+00:14:29,000 --> 00:14:29,020
+عملية تجارب، عملية تجارب، عملية تجارب، عملية تجارب،
+
+157
+00:14:29,020 --> 00:14:41,420
+عملية تجارب، عملية تجارب، عملية تجارب، عملية
+
+158
+00:14:41,420 --> 00:14:48,910
+تجــارب. وجدوا أن الـ... الـ... أن بدء العلاج  للناس
+
+159
+00:14:48,910 --> 00:14:52,670
+الذين هم في مرحلة الـ... الـ pre-diabetes، تمامًا؟ يعني
+
+160
+00:14:52,670 --> 00:14:54,950
+الذين لا نستطيع أن نقول أن هؤلاء لديهم type 2
+
+161
+00:14:54,950 --> 00:14:57,550
+diabetes mellitus، لسه هم في مرحلة الـ pre-diabetes،
+
+162
+00:14:57,550 --> 00:15:02,150
+وجدوا أن عندما يكون هناك تدخل علاجي، هذا يمكن
+
+163
+00:15:02,150 --> 00:15:10,390
+أن يؤخر progression لـ diabetes، وكان
+
+164
+00:15:10,390 --> 00:15:16,670
+معناه أن هناك فائدة حقيقية من الـ
+
+165
+00:15:16,670 --> 00:15:22,210
+screening، بخلاف type 1 diabetes mellitus.
+
+166
+00:15:23,580 --> 00:15:26,520
+طيب، فيما يتعلق بالـ diagnosis،  نحكي عن الـ
+
+167
+00:15:26,520 --> 00:15:29,720
+clinical cases، أي الناس الذين ظهرت لديهم الـ
+
+168
+00:15:29,720 --> 00:15:34,260
+symptoms.  laboratory diagnosis made exclusively
+
+169
+00:15:34,260 --> 00:15:38,520
+by the demonstration of hyperglycemia. يعني هذا هو
+
+170
+00:15:38,520 --> 00:15:42,860
+المعتبر، أن نثبت أن هذا الشخص لديه ارتفاع في
+
+171
+00:15:42,860 --> 00:15:47,400
+مستوى الجلوكوز في الدم، عن طريق measuring
+
+172
+00:15:47,400 --> 00:15:52,200
+venous plasma glucose، أو عن طريق الـ hemoglobin A1C.
+
+173
+00:15:54,010 --> 00:15:56,790
+الإثبات، هو أن نقول أن هذا الشخص لديه
+
+174
+00:15:56,790 --> 00:16:01,130
+hyperglycemia. although other tests have been
+
+175
+00:16:01,130 --> 00:16:04,090
+proposed to assist in the diagnosis and
+
+176
+00:16:04,090 --> 00:16:07,230
+classification of the disease. these do not at
+
+177
+00:16:07,230 --> 00:16:11,930
+present have a role outside of research studies.
+
+178
+00:16:11,930 --> 00:16:17,250
+طبعًا، يبقى الفحوصات الأخرى، يعني كما يسمى، نقول
+
+179
+00:16:17,250 --> 00:16:20,250
+C-peptide،  مثل الأنسولين، يمكن أن تساعد في
+
+180
+00:16:20,250 --> 00:16:24,610
+الـ differential diagnosis، تمامًا،
+
+181
+00:16:24,610 --> 00:16:31,150
+لكن ليس لها أي ضرورة أن
+
+182
+00:16:31,150 --> 00:16:33,430
+تنعمل routinely.
+
diff --git a/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/yK1u3cVlgj0_postprocess.srt b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/yK1u3cVlgj0_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..60fd005f56e0b17c8971445b349381c7f7855af0
--- /dev/null
+++ b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/yK1u3cVlgj0_postprocess.srt
@@ -0,0 +1,740 @@
+1
+00:00:01,310 --> 00:00:05,770
+بسم الله الرحمن الرحيم نستكمل مع محاضرة ال
+
+2
+00:00:05,770 --> 00:00:13,110
+diabetes mellitus و المحاضرة التانية بداية بدنا
+
+3
+00:00:13,110 --> 00:00:20,550
+نحكي عن ال diagnosisواللقطة الأولى هتتعلق بـ Pre
+
+4
+00:00:20,550 --> 00:00:25,830
+-clinical diagnosis أو الـ Screening اللي هو
+
+5
+00:00:25,830 --> 00:00:32,390
+الفحوصات اللي ممكن نجريها وطبعا على يعني ال ..
+
+6
+00:00:32,390 --> 00:00:38,410
+المرضى المتوقع أنه يصابوا و
+
+7
+00:00:40,010 --> 00:00:47,490
+يعني يكون في عنا تدخل علاجي لمنع أو تأخير حدوث
+
+8
+00:00:47,490 --> 00:00:50,670
+المرض طبعا ال preclinical معناه احنا بنعني
+
+9
+00:00:50,670 --> 00:00:55,330
+patients او يعني بنعني اشخاص ال symptoms لسه
+
+10
+00:00:55,330 --> 00:00:59,380
+مظهرتش عليهمتمام يبقى pre-clinical أو اللي هو
+
+11
+00:00:59,380 --> 00:01:03,520
+بنحكي screening ال screening برضه نفس الفكرة أنه
+
+12
+00:01:03,520 --> 00:01:09,340
+بنعمل فحص لشخص ماظهرتش عليه ال symptoms عشان نشوف
+
+13
+00:01:09,340 --> 00:01:16,800
+إذا كان في عنده مرض معين أو لأ طبعا احنا ال .. ال
+
+14
+00:01:16,800 --> 00:01:22,600
+.. ال screening بديكون مفيد في حال أنه موجود عندنا
+
+15
+00:01:22,600 --> 00:01:28,030
+علاجطبعا يبقى إذا فيه عندنا علاج معناه ال
+
+16
+00:01:28,030 --> 00:01:34,510
+screening ممكن تكون عندنا مفيدة، الآن بما يتعلق
+
+17
+00:01:34,510 --> 00:01:39,230
+بيه ال animal studies يبقى صار فيه تجارب على ال
+
+18
+00:01:39,230 --> 00:01:45,550
+animals ويدروا أنه يعملواimmune intervention
+
+19
+00:01:45,550 --> 00:01:54,250
+therapy، بيقدروا يدخلوا، ومن خلال هذا التدخل يعني
+
+20
+00:01:54,250 --> 00:01:57,830
+كان في delay أو prevention لحدوث الـ type 1
+
+21
+00:01:57,830 --> 00:02:01,870
+diabetes, malnutrition and هذه الحيوانات
+
+22
+00:02:05,350 --> 00:02:09,890
+الان الدراسات اللي عملوها على الإنسان للأسف يعني
+
+23
+00:02:09,890 --> 00:02:14,590
+كانت disappointing يعني ما نجحتش اللي هو العلاجات
+
+24
+00:02:14,590 --> 00:02:20,790
+كما يعني نجحت عند الحيوانات لكن مع ذلك يعني بيضل
+
+25
+00:02:20,790 --> 00:02:26,670
+الأمل موجود و لسه في العديد من الدراسات و اللي هي
+
+26
+00:02:26,670 --> 00:02:31,450
+في عنا large clinical trials يعني شغالةوهذه ال
+
+27
+00:02:31,450 --> 00:02:37,790
+clinical trials بتحاول انه اتلاقي ال therapeutic
+
+28
+00:02:37,790 --> 00:02:42,170
+strategies لتأخير
+
+29
+00:02:42,170 --> 00:02:47,890
+او لمنع حدوث ال type 1 diabetes mellitusيبقى مثلًا
+
+30
+00:02:47,890 --> 00:02:55,390
+لغاية الآن مافيش عندنا طريقة علاجية مافيش عندنا لو
+
+31
+00:02:55,390 --> 00:03:02,610
+تدخل علاجي اللي ممكن نجل أو نمنع من حدوث ال type 1
+
+32
+00:03:02,610 --> 00:03:08,910
+diabetes mellitus يبقى بالتالي أنه نعمل screening
+
+33
+00:03:08,910 --> 00:03:15,910
+لإيه ال antibodies is not recommendedطبعا انه ال
+
+34
+00:03:15,910 --> 00:03:21,990
+.. ال .. المرضى اللي هو ال .. اللي ممكن يعني متوقع
+
+35
+00:03:21,990 --> 00:03:26,430
+انه يصابوا اذا كان عندهم في العائلة ممكن في ناس
+
+36
+00:03:26,430 --> 00:03:32,230
+مصابة و نيجي و نقعد نفحص لهدول المرضى و نشوف اذا
+
+37
+00:03:32,230 --> 00:03:36,670
+كان في عندهم antibodies من اللي ذكرناهم سابقا هذا
+
+38
+00:03:36,670 --> 00:03:42,150
+الموضوع is not recommended طبعايبقى ممكن يصير في
+
+39
+00:03:42,150 --> 00:03:46,950
+حال ان هدول يعني كانوا ممكن يعني بيشاركوا في
+
+40
+00:03:46,950 --> 00:03:54,770
+clinical studies لكن عشان نعمل screening و نحدد ان
+
+41
+00:03:54,770 --> 00:03:58,390
+هذا المريض هيصاب على او مش هيصاب يعني not
+
+42
+00:03:58,390 --> 00:04:01,550
+recommended لأن زي ما قولنا انه لغاية الآن مش عنا
+
+43
+00:04:01,550 --> 00:04:05,870
+يعني تدخل علاجه وبالتالي ايش الفائدة؟
+
+44
+00:04:08,210 --> 00:04:12,930
+ان نقول للشخص والله انت يعني احتمال كبير انك تصاب
+
+45
+00:04:12,930 --> 00:04:20,230
+او لأ بما تعلق بال screening ل ال type 2 diabetes
+
+46
+00:04:20,230 --> 00:04:20,790
+mellitus
+
+47
+00:04:23,610 --> 00:04:27,530
+التوصيات من قبل الـ American Diabetes Association
+
+48
+00:04:27,530 --> 00:04:36,970
+سابقاً كانت توصي يعني بعدم فحص الناس اللي هو at
+
+49
+00:04:36,970 --> 00:04:41,550
+higher risk للإصابة بـ type 2 diabetes mellitus
+
+50
+00:04:41,550 --> 00:04:45,610
+لكن
+
+51
+00:04:45,610 --> 00:04:54,870
+الآن اللي هو ال ADA بتنصح أنه يكون فيه screeningلـ
+
+52
+00:04:54,870 --> 00:04:58,730
+All asymptomatic individuals over the age of 45
+
+53
+00:04:58,730 --> 00:05:04,350
+years يبقى كل الأشخاص فوق الخمسة وأربعين بتنصح ال
+
+54
+00:05:04,350 --> 00:05:09,370
+American Diabetes Association أنه يعملوا فحص لل
+
+55
+00:05:09,370 --> 00:05:15,540
+glucose concentrationالخطوات الحالية تتضمن استخدام
+
+56
+00:05:15,540 --> 00:05:29,040
+Hemoglobin A1C لتسجيل التسجيل إذا كان
+
+57
+00:05:29,040 --> 00:05:36,070
+Hemoglobin A1C أقل من 5.7%أو في عندنا units أخرى
+
+58
+00:05:36,070 --> 00:05:40,370
+اللي هي ال hemoglobin A1C اللي هي ميلي مول لكل مول
+
+59
+00:05:40,370 --> 00:05:44,890
+ميلي مول اللي هو من ال hemoglobin A1C لكل مول من
+
+60
+00:05:44,890 --> 00:05:47,950
+ال hemoglobin اللي هو تسعة و تلاتين يعني خمسة
+
+61
+00:05:47,950 --> 00:05:55,270
+point سبعة أو تسعة و تلاتين أو ال fasting plasma
+
+62
+00:05:55,270 --> 00:05:57,790
+glucose less than one hundred milligram per
+
+63
+00:05:57,790 --> 00:06:01,290
+deciliter testing should be repeated at three
+
+64
+00:06:01,290 --> 00:06:06,110
+years intervalإذا كانت نتيجة طلعت للـ hemoglobin
+
+65
+00:06:06,110 --> 00:06:11,850
+A1C اللي هو أقل من 5.7 أو لال fasting plasma
+
+66
+00:06:11,850 --> 00:06:19,290
+glucose أقل من 100 يبقى ممكن هذا الشخص يعمل ال
+
+67
+00:06:19,290 --> 00:06:22,770
+glucose concentration أو اللي هو يعني ال
+
+68
+00:06:22,770 --> 00:06:31,090
+hemoglobin A1C كل 3 سنةالان الأمر بيختلف إذا كان
+
+69
+00:06:31,090 --> 00:06:38,840
+إن الشخص هذا في عنده risk factorsيبقى ال .. ال
+
+70
+00:06:38,840 --> 00:06:42,660
+testing maybe considered at a younger age يبقى مش
+
+71
+00:06:42,660 --> 00:06:50,220
+هنستنى لعمر 45 عشان يصير في عندنا يعني routine
+
+72
+00:06:50,220 --> 00:06:53,720
+اللي هو measurement أو frequent measurement لال ..
+
+73
+00:06:53,720 --> 00:06:57,500
+لglucose في الدم يبقى إذا كان عندنا risk factors
+
+74
+00:06:57,500 --> 00:07:02,940
+موجودة يبقى المفروض نبدأ at younger age
+
+75
+00:07:04,570 --> 00:07:10,370
+ويبدو يكون في عنا يعني الفحص هذا الـ more frequent
+
+76
+00:07:10,370 --> 00:07:13,910
+وطبعا زي ما انتوا عارفين من ال risk factors أنه
+
+77
+00:07:13,910 --> 00:07:17,350
+يكون في عنا family history يكون في أشخاص مصابين
+
+78
+00:07:17,350 --> 00:07:22,090
+اللي هو ال first degree relatives مصابين أو في عنا
+
+79
+00:07:22,090 --> 00:07:24,930
+اللي هو certain ethnic groups
+
+80
+00:07:26,700 --> 00:07:31,200
+برضه هدول أكتر عرضة زي اللي هو ال black أكتر عرضة
+
+81
+00:07:31,200 --> 00:07:36,320
+للإصابة بال type 2 diabetes mellitus أو يكون مثلا
+
+82
+00:07:36,320 --> 00:07:40,960
+obese طبعا كل هذه risk factors و فتالي هذه كلها
+
+83
+00:07:40,960 --> 00:07:46,560
+بتستدعي أن يكون في أنه يعني ما نصلش لسن خمسة
+
+84
+00:07:46,560 --> 00:07:53,260
+وأربعين ممكن يعني من سن مبكرةو ممكن يعني في بعض
+
+85
+00:07:53,260 --> 00:08:03,060
+الأحيان حتى يصير فينا فحص يعني بشكل مستمر للأطفال
+
+86
+00:08:03,060 --> 00:08:10,700
+حتى، اذا يعني كان في أكتر من risk factor موجود
+
+87
+00:08:13,630 --> 00:08:19,090
+و عشان هيك هو مع الارتفاع في عدد الأشخاص المصابين
+
+88
+00:08:19,090 --> 00:08:26,630
+بالtype 2 diabetes mellitus عند المراهقين بفيه صار
+
+89
+00:08:26,630 --> 00:08:34,690
+توصيات أنه يصير فيه screening لل overweight youth
+
+90
+00:08:36,270 --> 00:08:38,950
+يعني حتى عند اللي هو المراهقين أو اللي هو الشباب
+
+91
+00:08:38,950 --> 00:08:48,130
+يصير فيه screening في حال انه كانوا obese اللي هو
+
+92
+00:08:48,130 --> 00:08:52,330
+ال body mass index أكتر من اللي هو eighty five
+
+93
+00:08:52,330 --> 00:08:53,230
+percentile
+
+94
+00:08:57,280 --> 00:09:06,180
+زي ما واضحان بالشكل عندنا طبعا اللي هو فيه ال ..
+
+95
+00:09:06,180 --> 00:09:11,080
+ال healthy weight اعالج
+
+96
+00:09:11,080 --> 00:09:18,980
+من خمسة لخمسة و تمانين من خمسة و تمانين لخمسة و
+
+97
+00:09:18,980 --> 00:09:27,140
+تسعين عندنا اللي هو overweightوعنا اللي هو ال 95 و
+
+98
+00:09:27,140 --> 00:09:33,100
+أعلى اللي هو ال obese يبقى
+
+99
+00:09:33,100 --> 00:09:37,680
+الشباب أو المراهقين إذا كان ال body mass index
+
+100
+00:09:37,680 --> 00:09:40,400
+اللي هو أكتر من 85
+
+101
+00:09:43,280 --> 00:09:50,480
+مع وجود two risk factors يبقى الشرط الأول أن يكون
+
+102
+00:09:50,480 --> 00:09:55,620
+overweight تمام with any two of the following risk
+
+103
+00:09:55,620 --> 00:09:59,900
+factors مع اتنين من ال risk factors التالية يبقى
+
+104
+00:09:59,900 --> 00:10:05,620
+بهذه الحالة بينصح أنه يكون فيه screening ومتابعة
+
+105
+00:10:05,620 --> 00:10:09,010
+مستمرةلهدول الأشخاص ايش risk factors؟ they have
+
+106
+00:10:09,010 --> 00:10:12,010
+family history of type 2 diabetes malatus in first
+
+107
+00:10:12,010 --> 00:10:16,230
+or second degree relatives they belong to a
+
+108
+00:10:16,230 --> 00:10:22,030
+certain race or ethnic groupهالي و زي ما قلنا
+
+109
+00:10:22,030 --> 00:10:28,850
+عندنا ال black عصبي المثال يعني أكتر عرضة للإصابة
+
+110
+00:10:28,850 --> 00:10:32,530
+بال type 2 diabetes mellitus they have signs of
+
+111
+00:10:32,530 --> 00:10:36,990
+insulin resistance or conditions associated with
+
+112
+00:10:36,990 --> 00:10:40,610
+insulin resistance زي اللي هو ال conditions اللي
+
+113
+00:10:40,610 --> 00:10:45,250
+ذكرناهم سابقا وقولنا أنه بيكون في عند الأشخاص اللي
+
+114
+00:10:45,250 --> 00:10:49,010
+هو insulin resistanceأو ان يكون فيه maternal
+
+115
+00:10:49,010 --> 00:10:52,050
+history of diabetes or gestational diabetes
+
+116
+00:10:52,050 --> 00:10:56,770
+mellitus during the child's gestation ان يكون عند
+
+117
+00:10:56,770 --> 00:11:00,230
+الأم صار في gestational diabetes mellitus خلال
+
+118
+00:11:00,230 --> 00:11:06,360
+اللي هو حاملها بهذا الطفلتمام يبقى over weight مع
+
+119
+00:11:06,360 --> 00:11:10,080
+two risk factors مني من اللي ذكرناهم يبقى هذا
+
+120
+00:11:10,080 --> 00:11:16,120
+بيستدعي أنه يكون في عندنا screening حتى للأطفال
+
+121
+00:11:16,120 --> 00:11:23,240
+اللي هم over weight testing should be done every
+
+122
+00:11:23,240 --> 00:11:29,850
+three years starting at 10 years of ageطيب، الآن
+
+123
+00:11:29,850 --> 00:11:33,210
+إيش الاختلاف؟ يعني ال .. ال type 2 diabetes
+
+124
+00:11:33,210 --> 00:11:39,550
+mellitus برضه لغاية الآن فشله علاج، يعني فش علاج
+
+125
+00:11:39,550 --> 00:11:44,240
+للشخص يشفىتمام؟ زي ما حكينا بال type 1 diabetes
+
+126
+00:11:44,240 --> 00:11:47,900
+mellitus طب ليش في ال type 1 diabetes mellitus؟ لأ
+
+127
+00:11:47,900 --> 00:11:52,320
+it is not recommended أنه نعمل screening لأ ال
+
+128
+00:11:52,320 --> 00:11:55,940
+antibodies لكن هان أه بنقول أنه it is recommended
+
+129
+00:11:55,940 --> 00:12:01,520
+أنه نعمل فحص لجلوكوز و نشوف من الأشخاص اللي يعني
+
+130
+00:12:01,520 --> 00:12:07,420
+ممكن يصابوا الفرق هان يعني بين الحالة الأولى و
+
+131
+00:12:07,420 --> 00:12:13,870
+الحالة التانيةإنه عندنا عدد يعني مش بسيط له تقريبا
+
+132
+00:12:13,870 --> 00:12:20,390
+تلاتة و تلاتين بالميةمن الأشخاص اللي فعليًا عندهم
+
+133
+00:12:20,390 --> 00:12:24,670
+type 2 diabetes mellitus هدول بيكونوا undiagnosed
+
+134
+00:12:24,670 --> 00:12:29,290
+وإذا كان فاكرين لما حكينا على النسب في الأول ذكرنا
+
+135
+00:12:29,290 --> 00:12:35,190
+الأعداد اللي فعليًا مسجلة بشكل رسمي وكان في عندنا
+
+136
+00:12:35,190 --> 00:12:40,350
+عدد اللي هدول يعتبروا undiagnosed يعني هما عندهم
+
+137
+00:12:40,350 --> 00:12:44,410
+type 2 diabetes mellitus لكن فعليًا ماصل همش
+
+138
+00:12:44,410 --> 00:12:50,760
+diagnoses بعديبقى أهان لأنه إنه نسبة مش بسيطة من
+
+139
+00:12:50,760 --> 00:12:54,180
+الأشخاص بيكون في عندهم type 2 diabetes mellitus و
+
+140
+00:12:54,180 --> 00:12:59,120
+بيقعدوا فترة مصابين و في عندهم ارتفاع ممكن بالسكر
+
+141
+00:12:59,120 --> 00:13:04,790
+بالدم لكنundiagnosed وبالتالي طول هذه الفترة في ان
+
+142
+00:13:04,790 --> 00:13:10,270
+ارتفع بالسكر بدون اللي هو اي التدخل بدون اي علاج
+
+143
+00:13:10,270 --> 00:13:16,430
+وبالتالي ممكن يبدو بال complications يعني ان حالات
+
+144
+00:13:16,430 --> 00:13:20,130
+كتير لما بيصله diagnosis انه عنده type 2 diabetes
+
+145
+00:13:20,130 --> 00:13:25,310
+mellitus بيكون فعليا بدأ او بدت عنده ال
+
+146
+00:13:25,310 --> 00:13:30,880
+complicationsطبعا عشان هيك عشان النقطة هي دي طبعا
+
+147
+00:13:30,880 --> 00:13:36,480
+نصحوا أنه يكون فينا screening ل اللي هو يعني فوق
+
+148
+00:13:36,480 --> 00:13:40,360
+السن ال 45 أو زي ما قولنا at اللي هو younger age
+
+149
+00:13:40,660 --> 00:13:49,420
+للناس اللي عندهم high risk factors عشان إذا في
+
+150
+00:13:49,420 --> 00:13:54,660
+عندهم أوثار عندهم سكري تم اكتشاف الحالة مبكرا
+
+151
+00:13:54,660 --> 00:13:59,840
+وبالتالي يصير فيه اللي هو التدخل العلاجي طبعا مع
+
+152
+00:13:59,840 --> 00:14:03,000
+يعني الأمور الأخرى انقاس الوزن والرياضة وخلافه
+
+153
+00:14:03,000 --> 00:14:08,820
+وبالتالي يعني هنبعد من حدوث ال complications
+
+154
+00:14:13,200 --> 00:14:15,440
+في عملية تجارب تجارب تجارب عملية تجارب عملية تجارب
+
+155
+00:14:15,440 --> 00:14:21,380
+عملية تجارب عملية تجارب عملية تجارب عملية تجارب
+
+156
+00:14:21,380 --> 00:14:26,800
+عملية تجارب عملية تجارب عملية تجارب عملية تجارب
+
+157
+00:14:26,800 --> 00:14:28,880
+عملية تجارب عملية تجارب عملية تجارب عملية تجارب
+
+158
+00:14:28,880 --> 00:14:29,000
+عملية تجارب عملية تجارب عملية تجارب عملية تجارب
+
+159
+00:14:29,000 --> 00:14:29,020
+عملية تجارب عملية تجارب عملية تجارب عملية تجارب
+
+160
+00:14:29,020 --> 00:14:41,420
+عملية تجارب عملية تجارب عملية تجارب عملية
+
+161
+00:14:41,420 --> 00:14:48,910
+تجيعني وجدوا انه ال .. ال .. انه بدء العلاج لالناس
+
+162
+00:14:48,910 --> 00:14:52,670
+اللي في مرحلة ال .. ال pre-diabetes تمام؟ يعني
+
+163
+00:14:52,670 --> 00:14:54,950
+اللي لسه ما بتقدرش نقول ان هدول عندهم بتاع two
+
+164
+00:14:54,950 --> 00:14:57,550
+diabetes malatus لسه هو في مرحلة ال pre-diabetes
+
+165
+00:14:57,550 --> 00:15:02,150
+لجوا انه لما بيصير فيه انا تدخل علاجي هذا ممكن
+
+166
+00:15:02,150 --> 00:15:10,390
+يعني يعمل delay ل ال progression ل ال diabetesوكان
+
+167
+00:15:10,390 --> 00:15:16,670
+معناته يعني في يعني فائدة مجروح فعليًا من ال
+
+168
+00:15:16,670 --> 00:15:22,210
+screening ويعني بخلاف ال type 1 diabetes malitus
+
+169
+00:15:23,580 --> 00:15:26,520
+طيب بما يتعلق بالـ diagnosis طبعا احنا بنحكي لها
+
+170
+00:15:26,520 --> 00:15:29,720
+الـ clinical cases اللي الناس اللي ظهرت عندهم ال
+
+171
+00:15:29,720 --> 00:15:34,260
+symptoms ال laboratory diagnosis made exclusively
+
+172
+00:15:34,260 --> 00:15:38,520
+by the demonstration of hyperglycemia يعني هذا هو
+
+173
+00:15:38,520 --> 00:15:42,860
+المعتبر لأنه نثبت أن هذا الشخص عنده ارتفاع في
+
+174
+00:15:42,860 --> 00:15:47,400
+مستوى الجلوكوز بالدم عن طريق اللي هو ال measuring
+
+175
+00:15:47,400 --> 00:15:52,200
+venous plasma glucose أو عن طريق ال hemoglobin A1C
+
+176
+00:15:54,010 --> 00:15:56,790
+الإثبات إنه نقول إن هذا الشخص في عنده
+
+177
+00:15:56,790 --> 00:16:01,130
+hyperglycemia although other tests have been
+
+178
+00:16:01,130 --> 00:16:04,090
+proposed to assist in the diagnosis and
+
+179
+00:16:04,090 --> 00:16:07,230
+classification of the disease these do not at
+
+180
+00:16:07,230 --> 00:16:11,930
+present have a role outside of research studies
+
+181
+00:16:11,930 --> 00:16:17,250
+طبعا يبقى الفحوصات التانيةأه يعني زي ما يسموه نقول
+
+182
+00:16:17,250 --> 00:16:20,250
+C-peptide زي اللي هو الانسولين، يعني ممكن هذه
+
+183
+00:16:20,250 --> 00:16:24,610
+تساعد في اللي هو ال differential diagnosis، تمام،
+
+184
+00:16:24,610 --> 00:16:31,150
+لكن يعني بعد هيك في الشيء ليها يعني أي لزوم أنه
+
+185
+00:16:31,150 --> 00:16:33,430
+تنعمل routinely
+
diff --git a/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/yK1u3cVlgj0_raw.json b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/yK1u3cVlgj0_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..5a1b96c1df28d2aa91ec9217de273cca0d5ce3e2
--- /dev/null
+++ b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/yK1u3cVlgj0_raw.json
@@ -0,0 +1 @@
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"text": "طبعا يبقى إذا فيه عندنا علاج معناه ال screening ممكن تكون عندنا مفيدة، الآن بما يتعلق بيه ال animal studies يبقى صار فيه تجارب على ال animals ويدروا أنه يعملوا", "tokens": [9566, 3555, 3615, 995, 7251, 3555, 4587, 7578, 11933, 15730, 8978, 3224, 43242, 8315, 11203, 26108, 20449, 8315, 3224, 2423, 17732, 3714, 43020, 6055, 30544, 43242, 8315, 3714, 5172, 25708, 3660, 12399, 6024, 48506, 4724, 15042, 7251, 2655, 30241, 4587, 4724, 1829, 3224, 2423, 5496, 5313, 7251, 3555, 4587, 7578, 20328, 9640, 8978, 3224, 6055, 7435, 9640, 3555, 15844, 2423, 4882, 4032, 25708, 2288, 14407, 14739, 3224, 7251, 25957, 1211, 14407], "avg_logprob": -0.15787760665019354, "compression_ratio": 1.5476190476190477, "no_speech_prob": 2.384185791015625e-07, "words": [{"start": 84.19, "end": 84.61, "word": "طبعا", "probability": 0.83953857421875}, {"start": 84.61, "end": 85.27, "word": " يبقى", "probability": 0.8453369140625}, {"start": 85.27, "end": 85.91, "word": " إذا", "probability": 0.849609375}, 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{"start": 158.81, "end": 162.17, "word": " لتأخير", "probability": 0.96240234375}, {"start": 162.17, "end": 162.55, "word": " او", "probability": 0.8955078125}, {"start": 162.55, "end": 163.13, "word": " لمنع", "probability": 0.65966796875}, {"start": 163.13, "end": 163.49, "word": " حدوث", "probability": 0.9398193359375}, {"start": 163.49, "end": 163.65, "word": " ال", "probability": 0.52294921875}, {"start": 163.65, "end": 163.83, "word": " type", "probability": 0.83935546875}, {"start": 163.83, "end": 164.19, "word": " 1", "probability": 0.42431640625}, {"start": 164.19, "end": 165.13, "word": " diabetes", "probability": 0.74462890625}, {"start": 165.13, "end": 166.03, "word": " mellitus", "probability": 0.7356770833333334}], "temperature": 1.0}, {"id": 9, "seek": 19279, "start": 167.25, "end": 192.79, "text": "يبقى مثلًا لغاية الآن مافيش عندنا طريقة علاجية مافيش عندنا لو تدخل علاجي اللي ممكن نجل أو نمنع من حدوث ال type 1 diabetes mellitus يبقى بالتالي أنه نعمل screening لإيه ال antibodies is not recommended", "tokens": [1829, 3555, 4587, 7578, 50113, 1211, 14111, 995, 5296, 17082, 995, 10632, 6024, 48506, 19446, 41185, 8592, 43242, 8315, 23032, 16572, 28671, 11203, 26108, 10632, 19446, 41185, 8592, 43242, 8315, 45164, 6055, 3215, 9778, 1211, 11203, 26108, 1829, 13672, 1829, 3714, 43020, 8717, 7435, 1211, 34051, 8717, 27842, 3615, 9154, 11331, 3215, 2407, 12984, 2423, 2010, 502, 13881, 385, 285, 30973, 7251, 3555, 4587, 7578, 20666, 2655, 6027, 1829, 14739, 3224, 8717, 25957, 1211, 17732, 5296, 28814, 1829, 3224, 2423, 28356, 307, 406, 9628], "avg_logprob": -0.1950367717181935, "compression_ratio": 1.4644549763033174, "no_speech_prob": 0.0, "words": [{"start": 167.25, "end": 167.53, "word": "يبقى", "probability": 0.73089599609375}, {"start": 167.53, "end": 167.89, "word": " مثلًا", "probability": 0.889404296875}, {"start": 167.89, "end": 168.29, "word": " لغاية", "probability": 0.9788818359375}, {"start": 168.29, "end": 168.81, "word": " الآن", "probability": 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طبعا", "tokens": [9566, 3555, 3615, 995, 16472, 3224, 2423, 4386, 2423, 4386, 9673, 43042, 7578, 13672, 1829, 31439, 2423, 4386, 13672, 1829, 3714, 43020, 37495, 22653, 44650, 30543, 3615, 16472, 3224, 7251, 9381, 16758, 14407, 1975, 15730, 25961, 43242, 16095, 8978, 18863, 16373, 37977, 3714, 43020, 8978, 8717, 32277, 3714, 9381, 16758, 3660, 4032, 8717, 1829, 7435, 1829, 4032, 8717, 4587, 22488, 8717, 5172, 5016, 9381, 46740, 3215, 12610, 9673, 43042, 7578, 4032, 8717, 8592, 38688, 1975, 15730, 25961, 8978, 43242, 16095, 28356, 9154, 13672, 1829, 29910, 37983, 8315, 16095, 8608, 16758, 4587, 995, 23758, 9673, 2407, 11242, 45367, 307, 406, 9628, 23032, 3555, 3615, 995], "avg_logprob": -0.09419642630077543, "compression_ratio": 1.847926267281106, "no_speech_prob": 1.6689300537109375e-06, "words": [{"start": 194.01, "end": 194.41, "word": "طبعا", "probability": 0.82025146484375}, {"start": 194.41, "end": 195.51, "word": " انه", "probability": 0.6846923828125}, {"start": 195.51, "end": 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هدول يعني كانوا ممكن يعني بيشاركوا في clinical studies لكن عشان نعمل screening و نحدد ان هذا المريض هيصاب على او مش هيصاب يعني not recommended لأن زي ما قولنا انه لغاية الآن مش عنا يعني تدخل علاجه وبالتالي ايش الفائدة؟", "tokens": [1829, 3555, 4587, 7578, 3714, 43020, 7251, 9381, 13546, 8978, 11331, 6027, 16472, 8032, 3215, 12610, 37495, 22653, 25961, 14407, 3714, 43020, 37495, 22653, 4724, 1829, 8592, 9640, 4117, 14407, 8978, 9115, 5313, 44381, 6225, 8592, 7649, 8717, 25957, 1211, 17732, 4032, 8717, 24401, 3215, 16472, 23758, 9673, 16572, 11242, 39896, 9381, 16758, 15844, 1975, 2407, 37893, 39896, 9381, 16758, 37495, 22653, 406, 9628, 5296, 33456, 30767, 1829, 19446, 12174, 12610, 8315, 16472, 3224, 5296, 17082, 995, 10632, 6024, 48506, 37893, 6225, 8315, 37495, 22653, 6055, 3215, 9778, 1211, 11203, 26108, 3224, 46599, 6027, 2655, 6027, 1829, 1975, 1829, 8592, 27188, 16373, 41891, 22807], "avg_logprob": -0.1700892925262451, "compression_ratio": 1.6475409836065573, "no_speech_prob": 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احتمال كبير انك تصاب او لأ بما تعلق بال screening ل ال type 2 diabetes mellitus", "tokens": [7649, 8717, 39648, 24976, 8592, 9778, 9381, 16070, 43761, 16472, 2655, 37495, 22653, 1975, 33753, 2304, 6027, 9122, 3555, 13546, 16472, 4117, 6055, 9381, 16758, 1975, 2407, 5296, 10721, 4724, 15042, 6055, 30241, 4587, 20666, 17732, 5296, 2423, 2010, 568, 13881, 385, 285, 30973], "avg_logprob": -0.20381944311989678, "compression_ratio": 1.2222222222222223, "no_speech_prob": 0.0, "words": [{"start": 248.21, "end": 248.97, "word": "ان", "probability": 0.1905517578125}, {"start": 248.97, "end": 249.19, "word": " نقول", "probability": 0.8076171875}, {"start": 249.19, "end": 249.65, "word": " للشخص", "probability": 0.96044921875}, {"start": 249.65, "end": 249.91, "word": " والله", "probability": 0.6947021484375}, {"start": 249.91, "end": 250.27, "word": " انت", "probability": 0.856689453125}, {"start": 250.27, "end": 250.59, "word": " يعني", "probability": 0.928955078125}, {"start": 250.59, "end": 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"seek": 49070, "start": 471.32, "end": 490.7, "text": "و ممكن يعني في بعض الأحيان حتى يصير فينا فحص يعني بشكل مستمر للأطفال حتى، اذا يعني كان في أكتر من risk factor موجود", "tokens": [2407, 3714, 43020, 37495, 22653, 8978, 45030, 11242, 16247, 5016, 1829, 7649, 11331, 49975, 7251, 9381, 13546, 8978, 8315, 6156, 5016, 9381, 37495, 22653, 4724, 8592, 28820, 3714, 14851, 29973, 24976, 10721, 9566, 5172, 6027, 11331, 49975, 12399, 1975, 15730, 37495, 22653, 25961, 8978, 5551, 4117, 2655, 2288, 9154, 3148, 5952, 3714, 29245, 23328], "avg_logprob": -0.15823863257061352, "compression_ratio": 1.4071428571428573, "no_speech_prob": 0.0, "words": [{"start": 471.32, "end": 471.62, "word": "و", "probability": 0.529296875}, {"start": 471.62, "end": 472.24, "word": " ممكن", "probability": 0.785400390625}, {"start": 472.24, "end": 472.66, "word": " يعني", "probability": 0.9365234375}, {"start": 472.66, "end": 472.88, "word": " في", "probability": 0.93896484375}, {"start": 472.88, "end": 473.26, 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58040, "start": 562.56, "end": 580.4, "text": "وعنا اللي هو ال 95 و أعلى اللي هو ال obese يبقى الشباب أو المراهقين إذا كان ال body mass index اللي هو أكتر من 85", "tokens": [2407, 3615, 8315, 13672, 1829, 31439, 2423, 13420, 4032, 5551, 3615, 23942, 13672, 1829, 31439, 2423, 50060, 7251, 3555, 4587, 7578, 25124, 3555, 16758, 34051, 9673, 23557, 3224, 4587, 9957, 11933, 15730, 25961, 2423, 1772, 2758, 8186, 13672, 1829, 31439, 5551, 4117, 2655, 2288, 9154, 14695], "avg_logprob": -0.14561170022538367, "compression_ratio": 1.3875968992248062, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 562.56, "end": 563.38, "word": "وعنا", "probability": 0.5760498046875}, {"start": 563.38, "end": 563.64, "word": " اللي", "probability": 0.901611328125}, {"start": 563.64, "end": 564.08, "word": " هو", "probability": 0.99365234375}, {"start": 564.08, "end": 564.48, "word": " ال", "probability": 0.74267578125}, {"start": 564.48, "end": 565.14, "word": " 95", "probability": 0.499267578125}, 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689.21, "end": 700.57, "text": "طيب، الآن إيش الاختلاف؟ يعني ال .. ال type 2 diabetes mellitus برضه لغاية الآن فشله علاج، يعني فش علاج للشخص يشفى", "tokens": [9566, 1829, 3555, 12399, 6024, 48506, 11933, 1829, 8592, 2423, 47283, 2655, 15040, 5172, 22807, 37495, 22653, 2423, 4386, 2423, 2010, 568, 13881, 385, 285, 30973, 4724, 43042, 3224, 5296, 17082, 995, 10632, 6024, 48506, 6156, 8592, 43761, 11203, 26108, 12399, 37495, 22653, 6156, 8592, 11203, 26108, 24976, 8592, 9778, 9381, 7251, 8592, 5172, 7578], "avg_logprob": -0.19252232808087552, "compression_ratio": 1.2907801418439717, "no_speech_prob": 0.0, "words": [{"start": 689.21, "end": 689.59, "word": "طيب،", "probability": 0.9193115234375}, {"start": 689.59, "end": 689.85, "word": " الآن", "probability": 0.59747314453125}, {"start": 689.85, "end": 690.07, "word": " إيش", "probability": 0.87841796875}, {"start": 690.07, "end": 690.81, "word": " الاختلاف؟", "probability": 0.8673909505208334}, {"start": 690.81, "end": 691.13, "word": " 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\ No newline at end of file
diff --git a/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/yK1u3cVlgj0_raw.srt b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/yK1u3cVlgj0_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..19fcdc762f807a789a8a105fc57b16c2270506c0
--- /dev/null
+++ b/PL9fwy3NUQKwYdRRRr6LHOswmzu1sJ9m-A/yK1u3cVlgj0_raw.srt
@@ -0,0 +1,744 @@
+1
+00:00:01,310 --> 00:00:05,770
+بسم الله الرحمن الرحيم نستكمل مع محاضرة ال
+
+2
+00:00:05,770 --> 00:00:13,110
+diabetes mellitus و المحاضرة التانية بداية بدنا
+
+3
+00:00:13,110 --> 00:00:20,550
+نحكي عن ال diagnosisواللقطة الأولى هتتعلق بـ Pre
+
+4
+00:00:20,550 --> 00:00:25,830
+-clinical diagnosis أو الـ Screening اللي هو
+
+5
+00:00:25,830 --> 00:00:32,390
+الفحوصات اللي ممكن نجريها وطبعا على يعني ال ..
+
+6
+00:00:32,390 --> 00:00:38,410
+المرضى المتوقع أنه يصابوا و
+
+7
+00:00:40,010 --> 00:00:47,490
+يعني يكون في عنا تدخل علاجي لمنع أو تأخير حدوث
+
+8
+00:00:47,490 --> 00:00:50,670
+المرض طبعا ال preclinical معناه احنا بنعني
+
+9
+00:00:50,670 --> 00:00:55,330
+patients او يعني بنعني اشخاص ال symptoms لسه
+
+10
+00:00:55,330 --> 00:00:59,380
+مظهرتش عليهمتمام يبقى pre-clinical أو اللي هو
+
+11
+00:00:59,380 --> 00:01:03,520
+بنحكي screening ال screening برضه نفس الفكرة أنه
+
+12
+00:01:03,520 --> 00:01:09,340
+بنعمل فحص لشخص ماظهرتش عليه ال symptoms عشان نشوف
+
+13
+00:01:09,340 --> 00:01:16,800
+إذا كان في عنده مرض معين أو لأ طبعا احنا ال .. ال
+
+14
+00:01:16,800 --> 00:01:22,600
+.. ال screening بديكون مفيد في حال أنه موجود عندنا
+
+15
+00:01:22,600 --> 00:01:28,030
+علاجطبعا يبقى إذا فيه عندنا علاج معناه ال
+
+16
+00:01:28,030 --> 00:01:34,510
+screening ممكن تكون عندنا مفيدة، الآن بما يتعلق
+
+17
+00:01:34,510 --> 00:01:39,230
+بيه ال animal studies يبقى صار فيه تجارب على ال
+
+18
+00:01:39,230 --> 00:01:45,550
+animals ويدروا أنه يعملواimmune intervention
+
+19
+00:01:45,550 --> 00:01:54,250
+therapy، بيقدروا يدخلوا، ومن خلال هذا التدخل يعني
+
+20
+00:01:54,250 --> 00:01:57,830
+كان في delay أو prevention لحدوث الـ type 1
+
+21
+00:01:57,830 --> 00:02:01,870
+diabetes, malnutrition and هذه الحيوانات
+
+22
+00:02:05,350 --> 00:02:09,890
+الان الدراسات اللي عملوها على الإنسان للأسف يعني
+
+23
+00:02:09,890 --> 00:02:14,590
+كانت disappointing يعني ما نجحتش اللي هو العلاجات
+
+24
+00:02:14,590 --> 00:02:20,790
+كما يعني نجحت عند الحيوانات لكن مع ذلك يعني بيضل
+
+25
+00:02:20,790 --> 00:02:26,670
+الأمل موجود و لسه في العديد من الدراسات و اللي هي
+
+26
+00:02:26,670 --> 00:02:31,450
+في عنا large clinical trials يعني شغالةوهذه ال
+
+27
+00:02:31,450 --> 00:02:37,790
+clinical trials بتحاول انه اتلاقي ال therapeutic
+
+28
+00:02:37,790 --> 00:02:42,170
+strategies لتأخير
+
+29
+00:02:42,170 --> 00:02:47,890
+او لمنع حدوث ال type 1 diabetes mellitusيبقى مثلًا
+
+30
+00:02:47,890 --> 00:02:55,390
+لغاية الآن مافيش عندنا طريقة علاجية مافيش عندنا لو
+
+31
+00:02:55,390 --> 00:03:02,610
+تدخل علاجي اللي ممكن نجل أو نمنع من حدوث ال type 1
+
+32
+00:03:02,610 --> 00:03:08,910
+diabetes mellitus يبقى بالتالي أنه نعمل screening
+
+33
+00:03:08,910 --> 00:03:15,910
+لإيه ال antibodies is not recommendedطبعا انه ال
+
+34
+00:03:15,910 --> 00:03:21,990
+.. ال .. المرضى اللي هو ال .. اللي ممكن يعني متوقع
+
+35
+00:03:21,990 --> 00:03:26,430
+انه يصابوا اذا كان عندهم في العائلة ممكن في ناس
+
+36
+00:03:26,430 --> 00:03:32,230
+مصابة و نيجي و نقعد نفحص لهدول المرضى و نشوف اذا
+
+37
+00:03:32,230 --> 00:03:36,670
+كان في عندهم antibodies من اللي ذكرناهم سابقا هذا
+
+38
+00:03:36,670 --> 00:03:42,150
+الموضوع is not recommended طبعايبقى ممكن يصير في
+
+39
+00:03:42,150 --> 00:03:46,950
+حال ان هدول يعني كانوا ممكن يعني بيشاركوا في
+
+40
+00:03:46,950 --> 00:03:54,770
+clinical studies لكن عشان نعمل screening و نحدد ان
+
+41
+00:03:54,770 --> 00:03:58,390
+هذا المريض هيصاب على او مش هيصاب يعني not
+
+42
+00:03:58,390 --> 00:04:01,550
+recommended لأن زي ما قولنا انه لغاية الآن مش عنا
+
+43
+00:04:01,550 --> 00:04:05,870
+يعني تدخل علاجه وبالتالي ايش الفائدة؟
+
+44
+00:04:08,210 --> 00:04:12,930
+ان نقول للشخص والله انت يعني احتمال كبير انك تصاب
+
+45
+00:04:12,930 --> 00:04:20,230
+او لأ بما تعلق بال screening ل ال type 2 diabetes
+
+46
+00:04:20,230 --> 00:04:20,790
+mellitus
+
+47
+00:04:23,610 --> 00:04:27,530
+التوصيات من قبل الـ American Diabetes Association
+
+48
+00:04:27,530 --> 00:04:36,970
+سابقاً كانت توصي يعني بعدم فحص الناس اللي هو at
+
+49
+00:04:36,970 --> 00:04:41,550
+higher risk للإصابة بـ type 2 diabetes mellitus
+
+50
+00:04:41,550 --> 00:04:45,610
+لكن
+
+51
+00:04:45,610 --> 00:04:54,870
+الآن اللي هو ال ADA بتنصح أنه يكون فيه screeningلـ
+
+52
+00:04:54,870 --> 00:04:58,730
+All asymptomatic individuals over the age of 45
+
+53
+00:04:58,730 --> 00:05:04,350
+years يبقى كل الأشخاص فوق الخمسة وأربعين بتنصح ال
+
+54
+00:05:04,350 --> 00:05:09,370
+American Diabetes Association أنه يعملوا فحص لل
+
+55
+00:05:09,370 --> 00:05:15,540
+glucose concentrationالخطوات الحالية تتضمن استخدام
+
+56
+00:05:15,540 --> 00:05:29,040
+Hemoglobin A1C لتسجيل التسجيل إذا كان
+
+57
+00:05:29,040 --> 00:05:36,070
+Hemoglobin A1C أقل من 5.7%أو في عندنا units أخرى
+
+58
+00:05:36,070 --> 00:05:40,370
+اللي هي ال hemoglobin A1C اللي هي ميلي مول لكل مول
+
+59
+00:05:40,370 --> 00:05:44,890
+ميلي مول اللي هو من ال hemoglobin A1C لكل مول من
+
+60
+00:05:44,890 --> 00:05:47,950
+ال hemoglobin اللي هو تسعة و تلاتين يعني خمسة
+
+61
+00:05:47,950 --> 00:05:55,270
+point سبعة أو تسعة و تلاتين أو ال fasting plasma
+
+62
+00:05:55,270 --> 00:05:57,790
+glucose less than one hundred milligram per
+
+63
+00:05:57,790 --> 00:06:01,290
+deciliter testing should be repeated at three
+
+64
+00:06:01,290 --> 00:06:06,110
+years intervalإذا كانت نتيجة طلعت للـ hemoglobin
+
+65
+00:06:06,110 --> 00:06:11,850
+A1C اللي هو أقل من 5.7 أو لال fasting plasma
+
+66
+00:06:11,850 --> 00:06:19,290
+glucose أقل من 100 يبقى ممكن هذا الشخص يعمل ال
+
+67
+00:06:19,290 --> 00:06:22,770
+glucose concentration أو اللي هو يعني ال
+
+68
+00:06:22,770 --> 00:06:31,090
+hemoglobin A1C كل 3 سنةالان الأمر بيختلف إذا كان
+
+69
+00:06:31,090 --> 00:06:38,840
+إن الشخص هذا في عنده risk factorsيبقى ال .. ال
+
+70
+00:06:38,840 --> 00:06:42,660
+testing maybe considered at a younger age يبقى مش
+
+71
+00:06:42,660 --> 00:06:50,220
+هنستنى لعمر 45 عشان يصير في عندنا يعني routine
+
+72
+00:06:50,220 --> 00:06:53,720
+اللي هو measurement أو frequent measurement لال ..
+
+73
+00:06:53,720 --> 00:06:57,500
+لglucose في الدم يبقى إذا كان عندنا risk factors
+
+74
+00:06:57,500 --> 00:07:02,940
+موجودة يبقى المفروض نبدأ at younger age
+
+75
+00:07:04,570 --> 00:07:10,370
+ويبدو يكون في عنا يعني الفحص هذا الـ more frequent
+
+76
+00:07:10,370 --> 00:07:13,910
+وطبعا زي ما انتوا عارفين من ال risk factors أنه
+
+77
+00:07:13,910 --> 00:07:17,350
+يكون في عنا family history يكون في أشخاص مصابين
+
+78
+00:07:17,350 --> 00:07:22,090
+اللي هو ال first degree relatives مصابين أو في عنا
+
+79
+00:07:22,090 --> 00:07:24,930
+اللي هو certain ethnic groups
+
+80
+00:07:26,700 --> 00:07:31,200
+برضه هدول أكتر عرضة زي اللي هو ال black أكتر عرضة
+
+81
+00:07:31,200 --> 00:07:36,320
+للإصابة بال type 2 diabetes mellitus أو يكون مثلا
+
+82
+00:07:36,320 --> 00:07:40,960
+obese طبعا كل هذه risk factors و فتالي هذه كلها
+
+83
+00:07:40,960 --> 00:07:46,560
+بتستدعي أن يكون في أنه يعني ما نصلش لسن خمسة
+
+84
+00:07:46,560 --> 00:07:53,260
+وأربعين ممكن يعني من سن مبكرةو ممكن يعني في بعض
+
+85
+00:07:53,260 --> 00:08:03,060
+الأحيان حتى يصير فينا فحص يعني بشكل مستمر للأطفال
+
+86
+00:08:03,060 --> 00:08:10,700
+حتى، اذا يعني كان في أكتر من risk factor موجود
+
+87
+00:08:13,630 --> 00:08:19,090
+و عشان هيك هو مع الارتفاع في عدد الأشخاص المصابين
+
+88
+00:08:19,090 --> 00:08:26,630
+بالtype 2 diabetes mellitus عند المراهقين بفيه صار
+
+89
+00:08:26,630 --> 00:08:34,690
+توصيات أنه يصير فيه screening لل overweight youth
+
+90
+00:08:36,270 --> 00:08:38,950
+يعني حتى عند اللي هو المراهقين أو اللي هو الشباب
+
+91
+00:08:38,950 --> 00:08:48,130
+يصير فيه screening في حال انه كانوا obese اللي هو
+
+92
+00:08:48,130 --> 00:08:52,330
+ال body mass index أكتر من اللي هو eighty five
+
+93
+00:08:52,330 --> 00:08:53,230
+percentile
+
+94
+00:08:57,280 --> 00:09:06,180
+زي ما واضحان بالشكل عندنا طبعا اللي هو فيه ال ..
+
+95
+00:09:06,180 --> 00:09:11,080
+ال healthy weight اعالج
+
+96
+00:09:11,080 --> 00:09:18,980
+من خمسة لخمسة و تمانين من خمسة و تمانين لخمسة و
+
+97
+00:09:18,980 --> 00:09:27,140
+تسعين عندنا اللي هو overweightوعنا اللي هو ال 95 و
+
+98
+00:09:27,140 --> 00:09:33,100
+أعلى اللي هو ال obese يبقى
+
+99
+00:09:33,100 --> 00:09:37,680
+الشباب أو المراهقين إذا كان ال body mass index
+
+100
+00:09:37,680 --> 00:09:40,400
+اللي هو أكتر من 85
+
+101
+00:09:43,280 --> 00:09:50,480
+مع وجود two risk factors يبقى الشرط الأول أن يكون
+
+102
+00:09:50,480 --> 00:09:55,620
+overweight تمام with any two of the following risk
+
+103
+00:09:55,620 --> 00:09:59,900
+factors مع اتنين من ال risk factors التالية يبقى
+
+104
+00:09:59,900 --> 00:10:05,620
+بهذه الحالة بينصح أنه يكون فيه screening ومتابعة
+
+105
+00:10:05,620 --> 00:10:09,010
+مستمرةلهدول الأشخاص ايش risk factors؟ they have
+
+106
+00:10:09,010 --> 00:10:12,010
+family history of type 2 diabetes malatus in first
+
+107
+00:10:12,010 --> 00:10:16,230
+or second degree relatives they belong to a
+
+108
+00:10:16,230 --> 00:10:22,030
+certain race or ethnic groupهالي و زي ما قلنا
+
+109
+00:10:22,030 --> 00:10:28,850
+عندنا ال black عصبي المثال يعني أكتر عرضة للإصابة
+
+110
+00:10:28,850 --> 00:10:32,530
+بال type 2 diabetes mellitus they have signs of
+
+111
+00:10:32,530 --> 00:10:36,990
+insulin resistance or conditions associated with
+
+112
+00:10:36,990 --> 00:10:40,610
+insulin resistance زي اللي هو ال conditions اللي
+
+113
+00:10:40,610 --> 00:10:45,250
+ذكرناهم سابقا وقولنا أنه بيكون في عند الأشخاص اللي
+
+114
+00:10:45,250 --> 00:10:49,010
+هو insulin resistanceأو ان يكون فيه maternal
+
+115
+00:10:49,010 --> 00:10:52,050
+history of diabetes or gestational diabetes
+
+116
+00:10:52,050 --> 00:10:56,770
+mellitus during the child's gestation ان يكون عند
+
+117
+00:10:56,770 --> 00:11:00,230
+الأم صار في gestational diabetes mellitus خلال
+
+118
+00:11:00,230 --> 00:11:06,360
+اللي هو حاملها بهذا الطفلتمام يبقى over weight مع
+
+119
+00:11:06,360 --> 00:11:10,080
+two risk factors مني من اللي ذكرناهم يبقى هذا
+
+120
+00:11:10,080 --> 00:11:16,120
+بيستدعي أنه يكون في عندنا screening حتى للأطفال
+
+121
+00:11:16,120 --> 00:11:23,240
+اللي هم over weight testing should be done every
+
+122
+00:11:23,240 --> 00:11:29,850
+three years starting at 10 years of ageطيب، الآن
+
+123
+00:11:29,850 --> 00:11:33,210
+إيش الاختلاف؟ يعني ال .. ال type 2 diabetes
+
+124
+00:11:33,210 --> 00:11:39,550
+mellitus برضه لغاية الآن فشله علاج، يعني فش علاج
+
+125
+00:11:39,550 --> 00:11:44,240
+للشخص يشفىتمام؟ زي ما حكينا بال type 1 diabetes
+
+126
+00:11:44,240 --> 00:11:47,900
+mellitus طب ليش في ال type 1 diabetes mellitus؟ لأ
+
+127
+00:11:47,900 --> 00:11:52,320
+it is not recommended أنه نعمل screening لأ ال
+
+128
+00:11:52,320 --> 00:11:55,940
+antibodies لكن هان أه بنقول أنه it is recommended
+
+129
+00:11:55,940 --> 00:12:01,520
+أنه نعمل فحص لجلوكوز و نشوف من الأشخاص اللي يعني
+
+130
+00:12:01,520 --> 00:12:07,420
+ممكن يصابوا الفرق هان يعني بين الحالة الأولى و
+
+131
+00:12:07,420 --> 00:12:13,870
+الحالة التانيةإنه عندنا عدد يعني مش بسيط له تقريبا
+
+132
+00:12:13,870 --> 00:12:20,390
+تلاتة و تلاتين بالميةمن الأشخاص اللي فعليًا عندهم
+
+133
+00:12:20,390 --> 00:12:24,670
+type 2 diabetes mellitus هدول بيكونوا undiagnosed
+
+134
+00:12:24,670 --> 00:12:29,290
+وإذا كان فاكرين لما حكينا على النسب في الأول ذكرنا
+
+135
+00:12:29,290 --> 00:12:35,190
+الأعداد اللي فعليًا مسجلة بشكل رسمي وكان في عندنا
+
+136
+00:12:35,190 --> 00:12:40,350
+عدد اللي هدول يعتبروا undiagnosed يعني هما عندهم
+
+137
+00:12:40,350 --> 00:12:44,410
+type 2 diabetes mellitus لكن فعليًا ماصل همش
+
+138
+00:12:44,410 --> 00:12:50,760
+diagnoses بعديبقى أهان لأنه إنه نسبة مش بسيطة من
+
+139
+00:12:50,760 --> 00:12:54,180
+الأشخاص بيكون في عندهم type 2 diabetes mellitus و
+
+140
+00:12:54,180 --> 00:12:59,120
+بيقعدوا فترة مصابين و في عندهم ارتفاع ممكن بالسكر
+
+141
+00:12:59,120 --> 00:13:04,790
+بالدم لكنundiagnosed وبالتالي طول هذه الفترة في ان
+
+142
+00:13:04,790 --> 00:13:10,270
+ارتفع بالسكر بدون اللي هو اي التدخل بدون اي علاج
+
+143
+00:13:10,270 --> 00:13:16,430
+وبالتالي ممكن يبدو بال complications يعني ان حالات
+
+144
+00:13:16,430 --> 00:13:20,130
+كتير لما بيصله diagnosis انه عنده type 2 diabetes
+
+145
+00:13:20,130 --> 00:13:25,310
+mellitus بيكون فعليا بدأ او بدت عنده ال
+
+146
+00:13:25,310 --> 00:13:30,880
+complicationsطبعا عشان هيك عشان النقطة هي دي طبعا
+
+147
+00:13:30,880 --> 00:13:36,480
+نصحوا أنه يكون فينا screening ل اللي هو يعني فوق
+
+148
+00:13:36,480 --> 00:13:40,360
+السن ال 45 أو زي ما قولنا at اللي هو younger age
+
+149
+00:13:40,660 --> 00:13:49,420
+للناس اللي عندهم high risk factors عشان إذا في
+
+150
+00:13:49,420 --> 00:13:54,660
+عندهم أوثار عندهم سكري تم اكتشاف الحالة مبكرا
+
+151
+00:13:54,660 --> 00:13:59,840
+وبالتالي يصير فيه اللي هو التدخل العلاجي طبعا مع
+
+152
+00:13:59,840 --> 00:14:03,000
+يعني الأمور الأخرى انقاس الوزن والرياضة وخلافه
+
+153
+00:14:03,000 --> 00:14:08,820
+وبالتالي يعني هنبعد من حدوث ال complications
+
+154
+00:14:13,200 --> 00:14:15,440
+في عملية تجارب تجارب تجارب عملية تجارب عملية تجارب
+
+155
+00:14:15,440 --> 00:14:21,380
+عملية تجارب عملية تجارب عملية تجارب عملية تجارب
+
+156
+00:14:21,380 --> 00:14:26,800
+عملية تجارب عملية تجارب عملية تجارب عملية تجارب
+
+157
+00:14:26,800 --> 00:14:28,880
+عملية تجارب عملية تجارب عملية تجارب عملية تجارب
+
+158
+00:14:28,880 --> 00:14:29,000
+عملية تجارب عملية تجارب عملية تجارب عملية تجارب
+
+159
+00:14:29,000 --> 00:14:29,000
+عملية تجارب عملية تجارب عملية تجارب عملية تجارب
+
+160
+00:14:29,000 --> 00:14:29,020
+عملية تجارب عملية تجارب عملية تجارب عملية تجارب
+
+161
+00:14:29,020 --> 00:14:41,420
+عملية تجارب عملية تجارب عملية تجارب عملية
+
+162
+00:14:41,420 --> 00:14:48,910
+تجيعني وجدوا انه ال .. ال .. انه بدء العلاج لالناس
+
+163
+00:14:48,910 --> 00:14:52,670
+اللي في مرحلة ال .. ال pre-diabetes تمام؟ يعني
+
+164
+00:14:52,670 --> 00:14:54,950
+اللي لسه ما بتقدرش نقول ان هدول عندهم بتاع two
+
+165
+00:14:54,950 --> 00:14:57,550
+diabetes malatus لسه هو في مرحلة ال pre-diabetes
+
+166
+00:14:57,550 --> 00:15:02,150
+لجوا انه لما بيصير فيه انا تدخل علاجي هذا ممكن
+
+167
+00:15:02,150 --> 00:15:10,390
+يعني يعمل delay ل ال progression ل ال diabetesوكان
+
+168
+00:15:10,390 --> 00:15:16,670
+معناته يعني في يعني فائدة مجروح فعليًا من ال
+
+169
+00:15:16,670 --> 00:15:22,210
+screening ويعني بخلاف ال type 1 diabetes malitus
+
+170
+00:15:23,580 --> 00:15:26,520
+طيب بما يتعلق بالـ diagnosis طبعا احنا بنحكي لها
+
+171
+00:15:26,520 --> 00:15:29,720
+الـ clinical cases اللي الناس اللي ظهرت عندهم ال
+
+172
+00:15:29,720 --> 00:15:34,260
+symptoms ال laboratory diagnosis made exclusively
+
+173
+00:15:34,260 --> 00:15:38,520
+by the demonstration of hyperglycemia يعني هذا هو
+
+174
+00:15:38,520 --> 00:15:42,860
+المعتبر لأنه نثبت أن هذا الشخص عنده ارتفاع في
+
+175
+00:15:42,860 --> 00:15:47,400
+مستوى الجلوكوز بالدم عن طريق اللي هو ال measuring
+
+176
+00:15:47,400 --> 00:15:52,200
+venous plasma glucose أو عن طريق ال hemoglobin A1C
+
+177
+00:15:54,010 --> 00:15:56,790
+الإثبات إنه نقول إن هذا الشخص في عنده
+
+178
+00:15:56,790 --> 00:16:01,130
+hyperglycemia although other tests have been
+
+179
+00:16:01,130 --> 00:16:04,090
+proposed to assist in the diagnosis and
+
+180
+00:16:04,090 --> 00:16:07,230
+classification of the disease these do not at
+
+181
+00:16:07,230 --> 00:16:11,930
+present have a role outside of research studies
+
+182
+00:16:11,930 --> 00:16:17,250
+طبعا يبقى الفحوصات التانيةأه يعني زي ما يسموه نقول
+
+183
+00:16:17,250 --> 00:16:20,250
+C-peptide زي اللي هو الانسولين، يعني ممكن هذه
+
+184
+00:16:20,250 --> 00:16:24,610
+تساعد في اللي هو ال differential diagnosis، تمام،
+
+185
+00:16:24,610 --> 00:16:31,150
+لكن يعني بعد هيك في الشيء ليها يعني أي لزوم أنه
+
+186
+00:16:31,150 --> 00:16:33,430
+تنعمل routinely
+
diff --git a/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/HixDvRD-rzU.srt b/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/HixDvRD-rzU.srt
new file mode 100644
index 0000000000000000000000000000000000000000..5a0ddd31fac848da2854755a968d22b1f2461f88
--- /dev/null
+++ b/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/HixDvRD-rzU.srt
@@ -0,0 +1,1320 @@
+1
+00:00:00,000 --> 00:00:01,100
+موسيقى
+
+2
+00:00:20,640 --> 00:00:22,860
+أَعُوذُ بِاللَّهِ السَّمِيعِ العَلِيمِ مِنَ الشَّيطَانِ الرَّجِيمِ بِسْمِ
+
+3
+00:00:22,860 --> 00:00:25,940
+اللَّهِ الرَّحْمَنِ الرَّحِيمِ الحَمْدُ للهِ والصَّلاةُ والسَّلامُ عَلَى
+
+4
+00:00:25,940 --> 00:00:29,320
+المُصْطَفَى الأَمِينِ سَيِّدِنَا مُحَمَّدٍ وَعَلَى آلِهِ وَمنْ سَارَ عَلَى
+
+5
+00:00:29,320 --> 00:00:32,400
+دَرْجِ سُنَّتِهِ،  السلام عليكم. عشان الطلاق كيف
+
+6
+00:00:32,400 --> 00:00:36,820
+حَالِكُم؟ كيف أصبَحْتُم اليوم؟ كويسين إن شاء الله، كُلُّ
+
+7
+00:00:36,820 --> 00:00:39,740
+عام أنتم بخير إن شاء الله، بمناسبة يوم الأرض إن
+
+8
+00:00:39,740 --> 00:00:42,280
+شاء الله، والعام القادم تكون الأرض رجعت لأصحابها إن
+
+9
+00:00:42,280 --> 00:00:44,800
+شاء الله. تفضلي.
+
+10
+00:00:50,840 --> 00:00:53,880
+أه .. أه، إن شاء الله، شكراً. المحاضرة الماضية أخذنا
+
+11
+00:00:53,880 --> 00:00:56,500
+مع بعض عن كيف سَيَتِمُّ إعداد موازنة تكاليف الإنتاج غير
+
+12
+00:00:56,500 --> 00:00:59,500
+المباشر. حكينا أنه هنّ نوعين: إما متغيرة أو تابعة.
+
+13
+00:00:59,500 --> 00:01:02,260
+المحاضرة الماضية شرحنا موازنة تكاليف الإنتاج
+
+14
+00:01:02,260 --> 00:01:06,240
+المتغيرة، وحكينا سهلة، إما بتيجي نسبة أو رقم من حجم
+
+15
+00:01:06,240 --> 00:01:11,200
+الـ... خُذي بالك من حجم الإنتاج، بينما النوع الثاني
+
+16
+00:01:11,200 --> 00:01:14,180
+من التكليف هي الـ fixed أو التكاليف التابعة.
+
+17
+00:01:14,180 --> 00:01:20,210
+تفضلي يا أحلام، اقرأي لنا إيش كاتب... موزعة للتسويات على
+
+18
+00:01:20,210 --> 00:01:23,830
+الأشهر، الثورة المالية من جهة، إيش؟ ومبوبة، يعني
+
+19
+00:01:23,830 --> 00:01:27,890
+مصنفة أو مقسمة إلى توقيف التكاليف الثابتة النقدية
+
+20
+00:01:27,890 --> 00:01:31,350
+والدفترية من جهة أخرى. شكراً يا عدي، الكلام هذا
+
+21
+00:01:31,350 --> 00:01:34,270
+هناخذه الآن عملياً، فيه إيش لنا السؤال، نرجع
+
+22
+00:01:34,270 --> 00:01:40,670
+للسؤال يا أخوات؟ تفضلي يا هدى، اقرأي لنا السؤال. إذا
+
+23
+00:01:40,670 --> 00:01:44,610
+كان المعدل المالي لتحميل قيمة تكاليف الـ N-16
+
+24
+00:01:46,880 --> 00:01:50,380
+المتغيرة اللي احنا أخذناه، يعني ما بننشغلش عليها، و
+
+25
+00:01:50,380 --> 00:01:53,500
+جملة البرود من التكاليف الثابتة السنوية من هذه
+
+26
+00:01:53,500 --> 00:01:56,980
+التكلفة، اه هي اللي بيهمني الآن. دولار التكاليف
+
+27
+00:01:56,980 --> 00:01:59,960
+الثابتة السنوية، خذي بالك من كلمة سنوية، ستين ألف
+
+28
+00:01:59,960 --> 00:02:03,980
+دولار، والإهلاك للأصول الثابتة ثمانيتاشر ألف دينار،
+
+29
+00:02:03,980 --> 00:02:07,560
+والإهلاك ثمانيتاشر ألف، والساعة المعيارية... الساعة
+
+30
+00:02:07,560 --> 00:02:12,660
+المعيارية أخذناها المحاضرة الماضية، ده
+
+31
+00:02:12,660 --> 00:02:17,160
+خذي بالك هو موازنة إنتاج المنتجين بالمحتاج
+
+32
+00:02:17,160 --> 00:02:20,460
+التمييزي. احنا موازنة الإنتاج ما بنستخدمهاش في التاب
+
+33
+00:02:20,460 --> 00:02:26,480
+ده. إيش طالب منها؟ تحسي بموازنة التكاليف الإنتاجية
+
+34
+00:02:26,480 --> 00:02:31,180
+اللي بتحتاجيها. ماشي كده، عشان
+
+35
+00:02:31,180 --> 00:02:35,500
+أحسب موازنة التكاليف
+
+36
+00:02:35,500 --> 00:02:41,560
+الإنتاجية للفترة القادمة. مش بس عندي رقمين، التاب ده
+
+37
+00:02:41,560 --> 00:02:45,110
+طبعاً يا أخوات، بنحل على رقمين بس، اللي هم التكاليف
+
+38
+00:02:45,110 --> 00:02:46,850
+الثابتة اللي بيعطيني إياها أهم في السؤال، اللي هم في
+
+39
+00:02:46,850 --> 00:02:53,350
+السؤال هذا: 60 ألف دولار، والإهلاك فقط باقي
+
+40
+00:02:53,350 --> 00:02:59,570
+المعلومات بتكون، لا إيش ثاني؟ إذا عشان نجيب، سواء كانت
+
+41
+00:02:59,570 --> 00:03:03,270
+يا أخوات، وخذي بالك، موازنة التكاليف الإنتاجية أو
+
+42
+00:03:03,270 --> 00:03:08,230
+موازنة التسويق للمحاضرة القادمة أو الإدارية التابعة
+
+43
+00:03:08,230 --> 00:03:14,170
+بنحلها بنفس الطريقة، برقمين، بنعمل موازنة فقط إيش
+
+44
+00:03:14,170 --> 00:03:17,890
+الرقمين؟ تكاليف التابعة بيكون معطيني إياها، والإهلاك.
+
+45
+00:03:17,890 --> 00:03:23,190
+نبدأ نحل السؤال. بدي
+
+46
+00:03:23,190 --> 00:03:29,610
+أرسم الجدول عشان نبدأ نعبيه. خلّيني أجيب الأسود بس.
+
+47
+00:03:29,610 --> 00:03:37,930
+هنقول لك يا أخوات، نون، تكاليف نقدية، تكاليف دفترية،
+
+48
+00:03:37,930 --> 00:03:39,990
+الإجمالية.
+
+49
+00:03:50,560 --> 00:03:55,920
+وهان كمال الإجمالية، نون عندنا في السؤال: واحد، اثنين،
+
+50
+00:03:55,920 --> 00:04:02,820
+ثلاثة، أربعة. واحد، اثنين، ثلاثة، أربعة. إذا أنا أول حاجة
+
+51
+00:04:02,820 --> 00:04:05,580
+اللي لازم أكتبها اللي هي الزمن حسب ما أُعطيها في
+
+52
+00:04:05,580 --> 00:04:11,540
+السؤال: واحد، اثنين، ثلاثة، أربعة. في
+
+53
+00:04:11,540 --> 00:04:16,900
+السؤال هي مش موحدة، لا، هي بيكون خطأ مطبعي، هذا مش دعوة
+
+54
+00:04:16,900 --> 00:04:17,740
+بيكون خطأ مطبعي.
+
+55
+00:04:23,010 --> 00:04:28,070
+بدي أجيها إن أنا أجيب موازنة تكاليف الإنتاجية
+
+56
+00:04:28,070 --> 00:04:33,190
+الدفترية، والإهلاك، أو عفواً، النقدية، النقدية اللي
+
+57
+00:04:33,190 --> 00:04:35,350
+هي التكاليف التابعة، والإهلاك الدفترية. هقول لك يا
+
+58
+00:04:35,350 --> 00:04:43,870
+أخوات، التكاليف التابعة، قداش في السؤال؟ 60 ألف
+
+59
+00:04:43,870 --> 00:04:53,190
+دولار، قداش الإهلاك منها؟ 18 ألف. شوية شوية... إذا
+
+60
+00:04:53,190 --> 00:04:58,190
+عندنا التكاليف التابعة بتكون معطاة في السؤال،
+
+61
+00:04:58,190 --> 00:05:02,750
+ستين ألف، هنقسمها قسمين: إشي دفتري اللي هو الإهلاك،
+
+62
+00:05:02,750 --> 00:05:07,390
+وإشي نقدي. دائماً يا أخوات، الإهلاك بيجينا في
+
+63
+00:05:07,390 --> 00:05:12,930
+السؤال، دائماً. إذا كان الإهلاك ستين ألف، قداش
+
+64
+00:05:12,930 --> 00:05:17,610
+النقدي؟ عفواً، إذا كان الإهلاك ثمانيتاشر ألف، قداش
+
+65
+00:05:17,610 --> 00:05:25,330
+النقدي؟ ستين ناقص ثمانيتاشر، كده إيش بيعطينا؟ ممتازة.
+
+66
+00:05:25,330 --> 00:05:30,690
+إذاً
+
+67
+00:05:30,690 --> 00:05:37,950
+الطريقة الأولى لحساب التكاليف التابعة النقدية
+
+68
+00:05:37,950 --> 00:05:43,830
+بتساوي مجموع التكاليف التابعة، بيساوي التكاليف
+
+69
+00:05:43,830 --> 00:05:50,810
+النقدية زائد التكاليف الإهلاك.  وفي السؤال ما أعطينا
+
+70
+00:05:50,810 --> 00:05:55,470
+الإهلاك، احنا هنجيب النقدي. ممكن العكس، ماشي... إذاً
+
+71
+00:05:55,470 --> 00:05:59,490
+بدل عندي 18 ألف إهلاك، وأنا معي 60 ألف، بيكون 42
+
+72
+00:05:59,490 --> 00:06:06,450
+ألف نقدي. في طريقة ثانية، أصل فيها الـ 42 واللي
+
+73
+00:06:06,450 --> 00:06:12,510
+براحتك، هو إمشي عليه، أقول لك يا أخوات، 18 ألف اللي
+
+74
+00:06:12,510 --> 00:06:17,650
+هي الإهلاك، تقسيم الـ 60 ألف. طبعاً ده هتطلع نسبة.
+
+75
+00:06:20,870 --> 00:06:25,570
+يعني قداش نسبة الإهلاك لإجمالي التكاليف؟ 18000
+
+76
+00:06:25,570 --> 00:06:31,370
+تقسيم 60000، حتة رقم صغير. إذاً
+
+77
+00:06:31,370 --> 00:06:38,310
+كان الإهلاك 3 من 10، دا يِدِرْك قداش النقدي؟ 7، لأنه 100
+
+78
+00:06:38,310 --> 00:06:44,330
+%. ماشي. لو ضربت 7 من 10 في 60000، قداش هتعطيني؟
+
+79
+00:06:44,330 --> 00:06:50,490
+42000. إذاً إما تجيبيها كنسبة، أو تجيبيها على طول، حسب
+
+80
+00:06:50,490 --> 00:06:57,910
+طبعاً. إذا الطريقة الثانية تساوي
+
+81
+00:06:57,910 --> 00:07:05,230
+النسبة، شي النسبة، إني أنا أقسم الإهلاك، تقسيم
+
+82
+00:07:05,230 --> 00:07:09,870
+التكاليف التابعة، وبناء عليها بجيب قداش النقدي. إحنا
+
+83
+00:07:09,870 --> 00:07:13,990
+في سؤالنا هذا، خذي بالك، بدنا نجيب الحل بالمنطق.
+
+84
+00:07:14,820 --> 00:07:21,840
+عندنا 60 ألف دولار، 18 ألف بس إهلاك، لأن واضح أن الـ 18
+
+85
+00:07:21,840 --> 00:07:27,480
+ألف رقم صغير. يعني لو قسمتي 18 ÷ 60، هي ثلث، هيكون
+
+86
+00:07:27,480 --> 00:07:32,600
+الباقي أُشْمَالِهِ نقدي، هيكون الباقي نقدي، وقداش هو اللي
+
+87
+00:07:32,600 --> 00:07:39,280
+عيدها. قداش عندنا عدد الفترة الزمنية؟ أربعة أشهر، أو
+
+88
+00:07:39,280 --> 00:07:42,140
+أربعة فترات، هنقول هيك: 42 ألف
+
+89
+00:07:49,290 --> 00:07:59,650
+42 ألف. شكراً. شكراً، بركة رفيقي. تقسيم أربعة... أمسح هذا.
+
+90
+00:07:59,650 --> 00:08:06,770
+أنا حسبتها لك، لو سمحتوا. 42 ألف تقسيم أربعة، بس أنا
+
+91
+00:08:06,770 --> 00:08:16,170
+قداش؟ أعطينا 10500
+
+92
+00:08:16,170 --> 00:08:18,870
+ألف، اللي معطى في السؤال، تقسيم أربعة.
+
+93
+00:08:30,350 --> 00:08:34,350
+أعيدها ثانيةً، أعيدها. إذا كل اللي عملناه، حسبنا
+
+94
+00:08:34,350 --> 00:08:37,810
+نسبة النقدي، وحسبنا نسبة إيش؟ الدفتري، أو الإهلاك،
+
+95
+00:08:37,810 --> 00:08:42,830
+أول حاجة على الجدول، الـ 42 ألف، أنا وزّعتها على
+
+96
+00:08:42,830 --> 00:08:46,830
+أربعة، أنا هقول هيك: عشرة آلاف وخمسمائة، عشرة آلاف
+
+97
+00:08:46,830 --> 00:08:52,290
+وخمسمائة، عشرة آلاف وخمسمائة، عشرة آلاف وخمسمائة،
+
+98
+00:08:52,290 --> 00:08:56,250
+كده إيش لازم يطلعوا؟ 42 ألف، لازم الأرقام تكون سوية
+
+99
+00:08:56,250 --> 00:09:01,210
+في الترصيد اللي في التابعة.  اية قداش أن التكاليف
+
+100
+00:09:01,210 --> 00:09:04,190
+الدفترية، بعد ما... آية العوض، بعد ما خطّ... ما قسمنا
+
+101
+00:09:04,190 --> 00:09:11,450
+عفواً، على أربعة، أربعة آلاف وخمسمائة، هنوزّعها
+
+102
+00:09:11,450 --> 00:09:17,310
+بالتساوي. قداش الأصل مجموعها؟ لو هالحساب صح، لازم...
+
+103
+00:09:17,310 --> 00:09:22,630
+قداش هذا يجي؟ ستين ألف، ستين ألف. نجمعها: عشرة آلاف و
+
+104
+00:09:22,630 --> 00:09:24,290
+خمسمائة زي أربعة آلاف وخمسمائة.
+
+105
+00:09:29,510 --> 00:09:37,490
+طبعاً خذي بالك، هي متساوية، لازم
+
+106
+00:09:37,490 --> 00:09:44,110
+يطلع الإجمالي 60 ألف. أنا شكتش لأنها كبيرة، 150 مالها
+
+107
+00:09:44,110 --> 00:09:48,190
+يا أسمة، كتبت.
+
+108
+00:09:48,190 --> 00:09:52,710
+وأنا شاكّة في الموضوع. إذا كان كله مع بعضهم 60 ألف
+
+109
+00:09:52,710 --> 00:09:57,850
+كيف صار للواحد 150؟ واضحة ولا أعيدها يا أخواتي؟ أعيدها
+
+110
+00:09:57,850 --> 00:09:58,510
+ثانيةً؟
+
+111
+00:10:01,000 --> 00:10:14,420
+أعيدها؟ أعيدها؟  ناخد سؤال الـ sheet لأ
+
+112
+00:10:14,420 --> 00:10:18,080
+ده الـ sheet عن تكاليف الإدارية، بس هو في كل نفس الحل.
+
+113
+00:10:30,200 --> 00:10:36,340
+في عندنا sheet على التكاليف الإدارية، بنحلها شوية
+
+114
+00:10:36,340 --> 00:10:40,300
+والسؤال الرابع التكاليف التسويقية، ماشي. واضحة يا
+
+115
+00:10:40,300 --> 00:10:44,920
+أخوات، ولا أعيدها؟ فيها أي خلل أو مشكلة؟ فيها أي
+
+116
+00:10:44,920 --> 00:10:51,360
+خلل أو مشكلة؟ ننتقل الآن لموازنة التكاليف التسويقية.
+
+117
+00:10:51,360 --> 00:10:57,400
+ننتقل لموازنة التكاليف الـ... التسويقية. سؤال؟
+
+118
+00:10:58,550 --> 00:11:05,310
+Award Cremetal على التكاليف التسويقية، Award
+
+119
+00:11:05,310 --> 00:11:09,590
+Cremetal على التكاليف التسويقية. واضح يا أخوات؟ حل
+
+120
+00:11:09,590 --> 00:11:14,410
+الصحيح، ولا أعيد ثانيةً؟ أعيد ثانيةً؟  حنتقل الآن
+
+121
+00:11:14,410 --> 00:11:18,410
+لموازنة الـ marketing cost أو التكاليف التسويقية.
+
+122
+00:11:18,410 --> 00:11:24,210
+Award Cremetal على التكاليف التسويقية. آه يا غدير؟
+
+123
+00:11:24,210 --> 00:11:30,850
+زي... أيوة، الإعلانات؟ زي العمولة، زي التوزيع، هذه كلها
+
+124
+00:11:30,850 --> 00:11:34,550
+قامتلة على تكاليف إيش؟ التسويق. الدراسات اللي
+
+125
+00:11:34,550 --> 00:11:38,810
+بنعملها لحتى نشوف المستهلك، إيش طلباته، هذه
+
+126
+00:11:38,810 --> 00:11:42,830
+بنسميها تكاليف تسويقية. في حاجة في التسويق اسمها الـ
+
+127
+00:11:42,830 --> 00:11:46,750
+four piece، مين فاكرها؟ تفضلي سماح.  بول بول،
+
+128
+00:11:46,750 --> 00:11:52,650
+ممتازة سماح، اللي هي: المنتج، السعر، التوزيع،
+
+129
+00:11:52,650 --> 00:11:55,350
+الترويج. طبعاً هدول الأربعة إيش لهم إيش؟ إيش لهم
+
+130
+00:11:55,350 --> 00:12:00,280
+موازنة؟ إحنا في المادة هذه بدنا نحسب مع بعض كيف
+
+131
+00:12:00,280 --> 00:12:04,200
+بنجيب الـ budget تبع إيش؟ تبع التسويق. في عندنا
+
+132
+00:12:04,200 --> 00:12:09,420
+سؤال. تفضلي، مين حابب يقول؟ تفضلي، أو لأ؟ إذا كان
+
+133
+00:12:09,420 --> 00:12:12,300
+المعادِل المعيارِي لتحميل بنود التجارب التسويقية
+
+134
+00:12:12,300 --> 00:12:17,100
+المتغيرة 3% من قيمة المبيعات. نقف هنا شوية. عندي،
+
+135
+00:12:17,100 --> 00:12:22,800
+حطّ خط تحت قيمة، تحت قيمة المبيعات. إذا موازنة
+
+136
+00:12:22,800 --> 00:12:27,460
+التسويق، لازم يكون عندي المبيعات بالدولار. ما ينفعش
+
+137
+00:12:27,460 --> 00:12:32,220
+أعمل إنتاج، ما له دعوة بالإنتاج أصلاً، بالتسويق مبيعات
+
+138
+00:12:32,220 --> 00:12:36,860
+بالوحدة، ما له دعوة. إذا أول حاجة لما أجي أحسب موازنة
+
+139
+00:12:36,860 --> 00:12:40,620
+التكاليف التسويقية، لازم يكون أمامي المبيعات
+
+140
+00:12:40,620 --> 00:12:42,840
+بالدولار، اللي هي أول موازنة أخذناها في هذا الـ
+
+141
+00:12:42,840 --> 00:12:48,280
+chapter. معانا بنشتغل، مش معانا ما بنعرفش نشتغل. لما
+
+142
+00:12:48,280 --> 00:12:50,940
+يقول لك: ده كده المعادلة المعيارية. أخذناها المحاضرة
+
+143
+00:12:50,940 --> 00:12:54,420
+الماضية، معاناها للوحدة. يعني ده كانت التكلفة
+
+144
+00:12:54,420 --> 00:12:58,200
+التسويقية المتغيرة للوحدة كذا. نفس الأشياء. تفضلي.
+
+145
+00:12:58,200 --> 00:13:03,200
+أولاً، والتكلفة الثابتة السنوية 36102 دولار،
+
+146
+00:13:03,200 --> 00:13:07,840
+والإهلاك للأصول الثابتة 9846 دينار، وإيراد
+
+147
+00:13:07,840 --> 00:13:11,300
+المبيعات لأحد أهم منتجات الشركة، والبلغ 50% من
+
+148
+00:13:11,300 --> 00:13:15,260
+منتجات المؤسسة.  تكوين. احسبي الموازنة التسويقية؟
+
+149
+00:13:15,260 --> 00:13:17,420
+شكراً. يعني أنتِ طالبِة مني أحسب موازنة التسويق على
+
+150
+00:13:17,420 --> 00:13:22,040
+النوع المتغيرة والتابعة. هنلاقي طالع هنا في المعطيات
+
+151
+00:13:22,040 --> 00:13:28,840
+مين؟ فخذي بالك منيح، إيراد المبيعات، إيش معنى إيراد
+
+152
+00:13:28,840 --> 00:13:32,520
+المبيعات؟ المبيعات بالدولار. إيش معنى إيراد
+
+153
+00:13:32,520 --> 00:13:37,100
+المبيعات؟ المبيعات بالدولار، يعني ممكن يروح يتفرّسُف
+
+154
+00:13:37,100 --> 00:13:41,040
+علينا، يعطينا المبيعات بالوحدة. طيب، منشرش السؤال،
+
+155
+00:13:41,040 --> 00:13:45,900
+لازم يكون معطيني السعر. لو أعطانا المبيعات بالوحدة
+
+156
+00:13:45,900 --> 00:13:50,760
+والسعر، بالسعر بنِجِيب الإيراد. ماشي؟ لأن ده خذي بالي
+
+157
+00:13:50,760 --> 00:13:53,780
+هالي ممكن تيجي نقطة لف ودوران، لأنه يعطينا المبيعات
+
+158
+00:13:53,780 --> 00:13:56,340
+ويكتب لك بالوحدة، تروحي أنتِ حرام حالك لو الحال كله
+
+159
+00:13:56,340 --> 00:13:59,660
+غلط، فلازم تاخذي بالك. إذا أول حاجة تعلميها، إن مع
+
+160
+00:13:59,660 --> 00:14:03,620
+بعض موازنة تسويق، لازم يكون عندي موازنة المبيعات
+
+161
+00:14:03,620 --> 00:14:09,460
+بالدولار، أو بالمبالغ. ماشي؟ إذا مش موجودة في السؤال
+
+162
+00:14:09,460 --> 00:14:14,620
+لا يحلّ. بعد ذلك، معطيات زي ما اتعودنا، احنا طالب
+
+1
+
+223
+00:20:00,700 --> 00:20:07,000
+الرقم
+
+224
+00:20:07,000 --> 00:20:11,120
+هذا يا أخوات اللي بالأخضر، هأقسمه قسمين: نقدي
+
+225
+00:20:13,700 --> 00:20:17,200
+ودفتر. إذا السؤال يا أحلام، إحنا ليش عملنا هذه الخطوة؟
+
+226
+00:20:17,200 --> 00:20:21,000
+هذه ليست مثل... قبل شهور حللنا على طول؟ ممتاز، عشان
+
+227
+00:20:21,000 --> 00:20:23,660
+نفهم أكثر من المنتج، وظهر هذا الكلام في البيانات.
+
+228
+00:20:23,660 --> 00:20:27,760
+السؤال الآن، زي ما تعرضنا، سنجيب نسبة الهلاك وسنجيب
+
+229
+00:20:27,760 --> 00:20:31,800
+نسبة النقل. لكن السؤال: هل سنجيب نسبة الهلاك من
+
+230
+00:20:31,800 --> 00:20:40,850
+الرقم الجديد أم من أصل السؤال؟ واضح يا أخواتي، واضح.
+
+231
+00:20:40,850 --> 00:20:44,670
+في صياغة السؤال أن الإهلاك كان من الإجمالي، وليس من
+
+232
+00:20:44,670 --> 00:20:47,890
+رقم صغير، يعني الإهلاك للمؤسسة ككل، لأن خذ بالك
+
+233
+00:20:47,890 --> 00:20:51,470
+من هذه الملاحظة، سنحسب نسبة الإهلاك من إجمالي
+
+234
+00:20:51,470 --> 00:20:54,190
+المؤسسة، وليس من الجزئية التي أخذناها؛ الجزئية فقط
+
+235
+00:20:54,190 --> 00:20:57,510
+كانت ماذا؟  لا، منتج واحد. أنا بدأت أحسب، بدأت أحسب،
+
+236
+00:20:57,510 --> 00:21:06,360
+هذا الكل. دفتري سيساوي... سأجلب نسبته، أين هو؟ تسعة
+
+237
+00:21:06,360 --> 00:21:12,820
+وتمانية، وأربعة، وستة، تقسيم ثلاثة، ستمائة واثنين. انحلّ
+
+238
+00:21:12,820 --> 00:21:28,000
+السؤال. جداش يعطيك الناتج؟ جداش النسبة يا أخوات؟
+
+239
+00:21:28,000 --> 00:21:33,540
+27%. إذا كان الدفتر 27%، جداش عندك النقدي؟ ثلاثة و
+
+240
+00:21:33,540 --> 00:21:39,900
+جداش؟ مئة ناقص سبعة وعشرين؟ 73. نحلّ السؤال أم لازلنا؟
+
+241
+00:21:39,900 --> 00:21:44,180
+طيب، سبعة وعشرين في ماذا سأضربها؟ في الإجمالي الرئيسي
+
+242
+00:21:44,180 --> 00:21:47,860
+أم في الأخضر؟ في الأخضر، بالأخضر. ممتاز، سنقول
+
+243
+00:21:47,860 --> 00:21:52,500
+هكذا؟ إذا، الفكرة فقط أنّه لأنّه ذكر لي أنّه أنواع
+
+244
+00:21:52,500 --> 00:21:55,540
+منتجات، ضربنا الرقم في النسبة التي نحلّ بها، وهي
+
+245
+00:21:55,540 --> 00:21:59,940
+خمسون في المئة. توقفنا عن الإهلاك دائمًا، وليس غالبًا
+
+246
+00:21:59,940 --> 00:22:02,840
+أو نادرًا؛ دائمًا الإهلاك يُؤخذ من الإجمالي، ما علاقة
+
+247
+00:22:02,840 --> 00:22:11,830
+بتفاصيل المنتجات؟ سأقول: ثمانية عشر
+
+248
+00:22:11,830 --> 00:22:14,710
+ألفًا، وواحد، وخمسين، ضرب سبعة وعشرين في المئة، يُعطيني
+
+249
+00:22:14,710 --> 00:22:19,770
+رقمًا اسمه ثلاثة عشر
+
+250
+00:22:19,770 --> 00:22:22,830
+ألفًا، وخمسين، وثمانية، وثلاثين، فاصلة خمسة وعشرون.
+
+251
+00:22:22,830 --> 00:22:26,690
+ثلاثة عشر ألفًا، وخمسين، وثمانية، وثلاثين... ليس فاصلة.
+
+252
+00:22:26,690 --> 00:22:30,110
+ليس هو... أربعة آلاف... أربعة آلاف وثمانين...
+
+253
+00:22:30,110 --> 00:22:36,100
+و... سبعة وسبعين.
+
+254
+00:22:36,100 --> 00:22:37,900
+(Repetition removed)
+
+255
+00:22:37,900 --> 00:22:40,020
+(Repetition removed)
+
+256
+00:22:40,020 --> 00:22:42,180
+(Repetition removed)
+
+257
+00:22:42,180 --> 00:22:46,780
+(Repetition removed)
+
+258
+00:22:46,780 --> 00:22:47,140
+(Repetition removed)
+
+259
+00:22:47,140 --> 00:22:50,360
+(Repetition removed)
+
+260
+00:22:50,360 --> 00:22:59,220
+(Repetition removed)
+
+261
+00:22:59,220 --> 00:23:04,180
+وسبعين. آخذ هذا، أضعه مع دفتري، دفتري، دفتري، أم لازال
+
+262
+00:23:04,180 --> 00:23:12,160
+باقية خطوة؟ باقية خطوة. نقسمه على ماذا؟ سنقسمه عليهما،
+
+263
+00:23:12,160 --> 00:23:16,800
+كما فعلنا توًا، بتوزيع الدفتري أو الإهلاك على
+
+264
+00:23:16,800 --> 00:23:19,760
+أربع فترات، وليست فترة واحدة. فلا تنسوا تقسيمها عليهما،
+
+265
+00:23:19,760 --> 00:23:24,840
+فتظهر النتيجة... النتيجة خاطئة، آسفة. ارجعوا إلى الإنتاجية،
+
+266
+00:23:24,840 --> 00:23:29,280
+ستجدون نفس النتيجة. اقسموه على 4873 تقسيم
+
+267
+00:23:32,860 --> 00:23:38,840
+1218، وسنذهب إلى... سنذهب إلى... مثل الصورة 1218
+
+268
+00:23:38,840 --> 00:23:42,500
+لا تنسوا التقسيم يا جماعة، كثير من الطلبة نسوا التقسيم
+
+269
+00:23:42,500 --> 00:23:50,680
+على الفترات. لو جمعناها، يجب أن يظهر 4873. واضح أم
+
+270
+00:23:50,680 --> 00:23:56,040
+أعيدها؟ أعيدها؟ بقي لدينا النقدي، آه يا أحلام، كيف
+
+271
+00:23:56,040 --> 00:23:57,420
+سنجلب النقدي؟ ماذا؟
+
+272
+00:24:02,520 --> 00:24:07,340
+ثلاثة عشر ألفًا، وواحد، وخمسين، وتظهر الإجابة ثلاثة عشر
+
+273
+00:24:07,340 --> 00:24:12,300
+ألفًا، ومائة، وسبعة، وسبعين. ماذا سنفعل بها يا أحلام؟
+
+274
+00:24:12,300 --> 00:24:15,980
+سنتركها كما هي، وسأضعها هناك أم لازلنا؟ ممتاز.
+
+275
+00:24:15,980 --> 00:24:20,800
+شكرًا يا أحلام. شكرًا. تقسيم أربعة، لماذا الفترات؟ هكذا، ماذا
+
+276
+00:24:20,800 --> 00:24:25,960
+يعطينا؟ ثمانية آلاف، وثمانية آلاف، وثمانية آلاف، وثمانية
+
+277
+00:24:25,960 --> 00:24:26,400
+(Repetition removed)
+
+278
+00:24:26,400 --> 00:24:29,640
+(Repetition removed)
+
+279
+00:24:35,690 --> 00:24:43,570
+3294، 3294، المفروض
+
+280
+00:24:43,570 --> 00:24:51,250
+الإجمالي يكون ماذا؟
+
+281
+00:24:51,250 --> 00:24:59,030
+اسم الجدول الجامعي الأفقي 4512.
+
+282
+00:24:59,030 --> 00:25:00,970
+4512
+
+283
+00:25:05,540 --> 00:25:06,680
+4512، ليس
+
+284
+00:25:06,680 --> 00:25:28,940
+(Repetition removed)
+
+285
+00:25:36,260 --> 00:25:47,680
+لدينا آخر شيء في المحاضرة اليوم، انتهى.
+
+286
+00:25:47,680 --> 00:25:55,120
+أم لا؟ شكله أم لا؟
+
+287
+00:25:55,120 --> 00:25:58,700
+آخر
+
+288
+00:25:58,700 --> 00:26:02,200
+شيء في هذا الفصل، موازنة. تأكيد، في الوقت الحالي شيء
+
+289
+00:26:02,200 --> 00:26:03,240
+صحيح، لأنّه نفس الشرح.
+
+290
+00:26:06,120 --> 00:26:12,380
+التكاليف الإدارية، التي هي: أجور، فواتير، الأشياء
+
+291
+00:26:12,380 --> 00:26:17,600
+التابعة لها. تفضلي يا... موازنة التكاليف الإدارية،
+
+292
+00:26:17,600 --> 00:26:21,100
+أنواعها: واحد ملزم، اثنان غير ملزم. إما تكون
+
+293
+00:26:21,100 --> 00:26:25,440
+ملزمة، أي: رصد من عندي، إلزامها أو إشغالها. غير
+
+294
+00:26:25,440 --> 00:26:29,060
+ملزمة. تفضلي. للتكاليف الملزمة: التكاليف الملزمة هي
+
+295
+00:26:29,060 --> 00:26:32,180
+التي يحتاج إليها المشروع، ويعتمد عليها، ومن الصعب
+
+296
+00:26:32,180 --> 00:26:36,330
+تجنبها: التأمين والإهلاك. أنا عندي مصنع، يجب أن أفعله
+
+297
+00:26:36,330 --> 00:26:41,050
+تأمينًا إجباريًا، إهلاكًا، هكذا، إجباريًا أيضًا يا أخوات.
+
+298
+00:26:41,050 --> 00:26:44,050
+من الأمثلة التي لم تُذكر في الشريحة، هي: رواتب
+
+299
+00:26:44,050 --> 00:26:48,130
+الموظفين. طبعًا هذه زمنية. إذا، التكاليف المنظمة هي
+
+300
+00:26:48,130 --> 00:26:51,490
+التكاليف الإجبارية، وقد شرحناها في سلوك التكاليف. غصب
+
+301
+00:26:51,490 --> 00:26:55,930
+عني، بدأت أدفع. ليس هذا النوع فقط، التكاليف غير
+
+302
+00:26:55,930 --> 00:27:00,530
+منظمة: في خطة معينة. التكاليف غير المنظمة، غير... نعرف
+
+303
+00:27:00,530 --> 00:27:07,330
+آه، تكاليف غير منظمة، مثل البحوث. أريد باحثًا،
+
+304
+00:27:07,330 --> 00:27:10,750
+أدفع، لا أريد، انتهى، يعني. علاقات عامة، تكاليف
+
+305
+00:27:10,750 --> 00:27:15,830
+غير ملزمة، تكون اختيارية. نفعلها، ندفع، ندفع،
+
+306
+00:27:15,830 --> 00:27:19,290
+نفعلها، انتهى، يعني، تخضع لقرارات الإدارة.  
+
+307
+00:27:20,850 --> 00:27:25,570
+لنرى السؤال. هل هذا حلّتِهِ الطالبة بشكل جيد؟  ما كان هو؟
+
+308
+00:27:25,570 --> 00:27:28,710
+من يريد القراءة؟ تفضلي، لعلك تقرئين السؤال؟ بلغة
+
+309
+00:27:28,710 --> 00:27:32,330
+مبيعات شركة "قُنص" للموظفات المنزليات في Libra، سفر
+
+310
+00:27:32,330 --> 00:27:38,270
+3000. ألفان. ماذا يعني يا أخوات المبيعات؟ نُخرِجُ بالـ
+
+311
+00:27:38,270 --> 00:27:43,410
+... سؤال نحلّه، إذا رأينا واحدًا. السؤال نحلّه،
+
+312
+00:27:43,410 --> 00:27:48,450
+التكلفة الإدارية والإنتاجية للإنتاج. التكلفة
+
+313
+00:27:48,450 --> 00:27:51,490
+التسويقية والإدارية يجب أن تكون بالمبيعات، وليس
+
+314
+00:27:51,490 --> 00:27:54,270
+بالمبالغ. السؤال نحلّه. لا تحلّوه خطأ. ألفان
+
+315
+00:27:54,270 --> 00:27:56,690
+واحدة، أربعة آلاف واحدة، خمسة عشر ألفًا واحدة، ثلاثون
+
+316
+00:27:56,690 --> 00:28:02,430
+ألفًا واحدة. طيب. آه يا شماء، بدلًا من هذا، السعر ليس
+
+317
+00:28:02,430 --> 00:28:06,370
+سيكون مُعطّل؟ عشرة دنانير... وعشرة دنانير...
+
+318
+00:28:06,370 --> 00:28:10,290
+والإدارية... خمسة وخمسون، ستون... آه... و... و... و
+
+319
+00:28:10,290 --> 00:28:11,570
+(Repetition removed)
+
+320
+00:28:11,570 --> 00:28:12,530
+(Repetition removed)
+
+321
+00:28:12,530 --> 00:28:15,070
+(Repetition removed)
+
+322
+00:28:15,070 --> 00:28:15,610
+(Repetition removed)
+
+323
+00:28:15,610 --> 00:28:21,010
+(Repetition removed)
+
+324
+00:28:21,010 --> 00:28:21,510
+(Repetition removed)
+
+325
+00:28:21,510 --> 00:28:26,410
+(Repetition removed)
+
+326
+00:28:34,920 --> 00:28:43,900
+التكاليف الإدارية المتغيرة أم كيف سنجلبها، و
+
+327
+00:28:43,900 --> 00:28:52,240
+نسبة التكاليف المتغيرة الإدارية 5%، مع العلم أن
+
+328
+00:28:52,240 --> 00:29:01,080
+المدة الزمنية هي ثلاثة أشهر. من
+
+329
+00:29:01,080 --> 00:29:04,460
+يريد أن يخرج ليجلب لنا موازنة التكاليف الإدارية المتغيرة؟
+
+330
+00:29:07,900 --> 00:29:14,280
+فقط؟ من غير اسمها؟ آه يا هودا، سنساعدك، لن نتخلى
+
+331
+00:29:14,280 --> 00:29:18,740
+عنكِ في الوقت الصعب.  خلينا معكِ سهلة يا أخوات،
+
+332
+00:29:18,740 --> 00:29:24,140
+سنقول: أنتِ مخيّرة إما أن تصنعي موازنة الـ LED XY، أو أن تصنعي
+
+333
+00:29:24,140 --> 00:29:27,420
+موازنة X. الـ LED وصفت، أعود إليكِ، يعني؛ الاثنان صحيحان، لكن
+
+334
+00:29:27,420 --> 00:29:33,820
+اللقام يختلف. سنقول يا هودا، موازنة... لكن سنحلّها
+
+335
+00:29:33,820 --> 00:29:38,570
+بالأول...  ماشي.  سنحلّها على نفس الجدول. موازنة
+
+336
+00:29:38,570 --> 00:29:46,550
+التكاليف الإدارية المتغيرة لمنطقة الـ LED، إذا
+
+337
+00:29:46,550 --> 00:29:48,630
+كان الـ LED...  سنتبع هذا السؤال، الذي هكذا سؤال، سنتبعه
+
+338
+00:29:48,630 --> 00:29:55,730
+بشكل أفقي، كتابة الـ LED. سنقول: المبيعات بالوحدة،
+
+339
+00:29:55,730 --> 00:30:01,110
+العمود الأول، العمود الثاني: سعر البيع. العمود
+
+340
+00:30:01,110 --> 00:30:06,800
+الثالث: نسبة التكلفة المتغيرة. العمود الرابع:
+
+341
+00:30:06,800 --> 00:30:12,560
+الموازنة. إذا الناس بتاكلهم متغيرة، ممكن تكتبيها
+
+342
+00:30:12,560 --> 00:30:17,600
+بضمير أريح لك. بعدين الموازنة،علينا نحن خلصنا، نتمّد
+
+343
+00:30:17,600 --> 00:30:21,880
+هنا نجيب موازنات اللي... الصف... ستكتب تحت اللي هو
+
+344
+00:30:21,880 --> 00:30:32,380
+المبيعات من خلال الـ 2000 حتى الـ 90%. ماشي 2000، 10، 3
+
+345
+00:30:32,380 --> 00:30:32,900
+%
+
+346
+00:30:35,560 --> 00:30:43,820
+بعدين الصف...  لا، صف... صف... صف... أربعة آلاف، عشرة،
+
+347
+00:30:43,820 --> 00:30:51,240
+ثلاثة في المئة، ممكن
+
+348
+00:30:51,240 --> 00:30:55,040
+تعمليها، وممكن تُخَلّيها للطالبات، يعني خليها
+
+349
+00:30:55,040 --> 00:30:58,720
+للطالبات، أعطوهنّ النتائج، وأُنهي الفكرة يا أخوات، وأُنهي، ونعيدها. إذا، العمود الوحيد لزيادة الفقير، الذي
+
+350
+00:30:58,720 --> 00:31:02,180
+هو سعر البيع. لماذا؟ لأنه لم يُعطيني مبيعات بالوحدة.
+
+351
+00:31:02,180 --> 00:31:04,620
+صنعنا عمودًا حتى تتذكرن، يعني ممكن أنا أحسبها
+
+352
+00:31:04,620 --> 00:31:07,420
+Direct. أعطوهن النتائج لو سمحتن. يلا يا أسماء.
+
+353
+00:31:07,420 --> 00:31:13,440
+أعطيتها النتائج أم لازلنا؟
+
+354
+00:31:13,440 --> 00:31:19,080
+يلا يا آية العوضي، 600، 600، الثانية.
+
+355
+00:31:32,450 --> 00:31:40,110
+1200؟ ماذا كان عندي؟ نسبة التكاليف المتغيرة الإدارية
+
+356
+00:31:40,110 --> 00:31:43,570
+أنا أُجلتُكم، هي ليست بحاجة... أنا أجلتكم،
+
+357
+00:31:43,570 --> 00:31:49,150
+قلت لكم هذا السؤال ناقص شيء. خمسة؟ ماشي، معلش، خلاص.
+
+358
+00:31:49,150 --> 00:31:53,490
+صلّحوه في السؤال. 3%، لأنني كتبت هي... اجعلوها 3%، ماذا
+
+359
+00:31:53,490 --> 00:31:58,250
+كان هو؟ أنا لم أسير مع الأسئلة السابقة،
+
+360
+00:31:58,250 --> 00:32:02,120
+خليني مُساويًا.  وصفت في البيت، كان هو؟  هذا واضح، و
+
+361
+00:32:02,120 --> 00:32:06,780
+لا، نعيد؟  نُعيد ثانية؟ إما أن تقولي الـ LED وتأخذي X، و
+
+362
+00:32:06,780 --> 00:32:12,660
+Y، وبعدين تصفّي X و Y، أو أن تقولي X وتأخذي LED، وتصفّي Y.
+
+363
+00:32:12,660 --> 00:32:17,080
+الـ LED، وتصفّي كما أخذنا أول هذا الفصل. آخر شيء في
+
+364
+00:32:17,080 --> 00:32:20,340
+المحاضرة هذا اليوم: موازنات التكاليف الإدارية
+
+365
+00:32:20,340 --> 00:32:27,120
+التابعة. أهمس.
+
+366
+00:32:32,230 --> 00:32:41,210
+تريدين الحلّ؟  تفضلي، يالا يا آنتي.
+
+367
+00:32:41,210 --> 00:32:44,710
+سنصنع موازنة تكاليف التابعة الإدارية، تابعة
+
+368
+00:32:44,710 --> 00:32:45,730
+للمؤسسة كلها.
+
+369
+00:32:50,140 --> 00:32:52,960
+خذِ بالكِ، هي أسماء الآن ستعمل عملًا تعوّدنا عليه.
+
+370
+00:32:52,960 --> 00:32:56,300
+المؤسسة كلها. لكن، ممكن أن يأتي السؤال: احسب موازنة
+
+371
+00:32:56,300 --> 00:33:00,060
+تكلفة الإدارية لمنطقة الـ LED فقط. سأحلّها أنا، لكن لنكن
+
+372
+00:33:00,060 --> 00:33:03,300
+في الشكل العام، يعني، خلينا مع أسماء الآن. كيف يعني يا
+
+373
+00:33:03,300 --> 00:33:06,980
+عزيزتي؟ حلّي أسئلة الـ LED فقط؟ لا، ستحلينّ ماذا؟
+
+374
+00:33:06,980 --> 00:33:13,840
+يقول السؤال: احسب موازنة تكلفة الإدارية التابعة في
+
+375
+00:33:13,840 --> 00:33:18,180
+السؤال.
+
+376
+00:33:18,180 --> 00:33:26,900
+ماذا؟ خمسة وستين ألفًا وستمائة وأربعين، ولم يُعطِني
+
+377
+00:33:26,900 --> 00:33:31,940
+نسبة الإهلاك، التي هي... هو رقم الإهلاك، ليس النسبة.
+
+378
+00:33:31,940 --> 00:33:35,040
+ماذا؟ رقم الإهلاك؟ مئة وثمانية وعشرون... مئة وثمانية
+
+379
+00:33:35,040 --> 00:33:40,160
+وعشرون. ننقص الإهلاك من الإجمالي كله. ممكن أن تنقصي، ممكن أن
+
+380
+00:33:40,160 --> 00:33:48,260
+تنقصي من ما تُريدينه. خذي الشيء... آه.
+
+381
+00:33:48,260 --> 00:33:54,150
+يا أخوات، احسبوا له سريعًا.  وإذا قسمتي، سيظهر 2
+
+382
+00:33:54,150 --> 00:34:01,810
+%?  طيب، نقصي... آه، أنتِ على طولها 52512
+
+383
+00:34:01,810 --> 00:34:04,970
+52512
+
+384
+00:34:04,970 --> 00:34:11,510
+هل أنتِ يا أسماء صنعت الجدول، أم حللتِ مباشرةً؟ ماشي.
+
+385
+00:34:11,510 --> 00:34:16,610
+يعني، الآن... آه. الرقم الذي ظهر، أعطوه للبنات.
+
+386
+00:34:16,610 --> 00:34:22,910
+ستقسمينه على شيء أم ستتركينه كما هو؟ سنقسمه على ثلاثة.
+
+387
+00:34:22,910 --> 00:34:33,210
+ممتازة. أم ماذا؟ سنقسمه على نون؟ ثلاثة.  ماذا
+
+388
+00:34:33,210 --> 00:34:36,970
+يظهر يا قوم؟ سبعة عشر ألفًا وخمسمائة وأربعة. سبعة عشر
+
+389
+00:34:36,970 --> 00:34:42,050
+ألفًا وخمسمائة وأربعة. أسماء...
+
+390
+00
\ No newline at end of file
diff --git a/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/IdUFBgVym40_postprocess.srt b/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/IdUFBgVym40_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..b73ab1b305b791bfaf5ec857e729710c37649ac1
--- /dev/null
+++ b/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/IdUFBgVym40_postprocess.srt
@@ -0,0 +1,408 @@
+1
+00:00:20,720 --> 00:00:23,020
+عودوا بالله السميع العليه من الشيطان الرجيم بسم
+
+2
+00:00:23,020 --> 00:00:25,780
+الله الرحمن الرحيم الحمد لله والصلاة والسلام على
+
+3
+00:00:25,780 --> 00:00:29,540
+مصطفى الأمين سيدنا محمد وعلى آله ومن ساره على درجة
+
+4
+00:00:29,540 --> 00:00:32,380
+حساب الدين في البداية السلام عليكم ورحمة الله كيف
+
+5
+00:00:32,380 --> 00:00:35,560
+حالكم؟ كيف أسبحتوا اليوم؟ كل عام انتوا بخير،
+
+6
+00:00:35,560 --> 00:00:39,220
+بمناسبة بدء الفصل الدراسي الجديد، بتمنى ان شاء
+
+7
+00:00:39,220 --> 00:00:44,740
+الله يكون فصل مميز وممتع ومليء بالنشاط والحيوية زي
+
+8
+00:00:44,740 --> 00:00:48,750
+كل فصل اتعودنا فيه معاكمالفصل هذا ان شاء الله راح
+
+9
+00:00:48,750 --> 00:00:53,670
+نكون مع بعض في رحلة مع مساق المحاسبة الإدارية إذا
+
+10
+00:00:53,670 --> 00:00:56,510
+المادة اللي بين أيدينا إيش اسمها؟ المحاسبة
+
+11
+00:00:56,510 --> 00:01:02,670
+الإدارية علم بيجمع بين علم المحاسبة و علم إيش؟ علم
+
+12
+00:01:02,670 --> 00:01:08,430
+الإدارية تم توزيع عليك وصف المساق قبل قليل خلينا
+
+13
+00:01:08,430 --> 00:01:12,350
+نناقشه مع بعض، نشوف مع بعض طبعا المادة اسمها
+
+14
+00:01:12,350 --> 00:01:16,700
+محاسبة إداريةإيش هداف المادة؟ هنتعرف فيها على
+
+15
+00:01:16,700 --> 00:01:20,320
+مبادئ المحاسبة الإدارية الطالب إن شاء الله لما
+
+16
+00:01:20,320 --> 00:01:24,060
+تخلص المادة هذه هيكون عندها قدرة على إعداد
+
+17
+00:01:24,060 --> 00:01:29,380
+التقارير المحاسبية والإدارية هيكون عندها قدرة على
+
+18
+00:01:29,380 --> 00:01:33,800
+حساب التكاليف الـ Yield Cost أيضًا في المادة هذه
+
+19
+00:01:33,800 --> 00:01:37,720
+إن شاء الله راح نشوف مع بعض آخر ما توصل إلى العلم
+
+20
+00:01:37,720 --> 00:01:40,520
+الحديد في المحاسبة الإدارية
+
+21
+00:01:42,580 --> 00:01:46,440
+زي ما حكينا، هيتم إعداد تقرير محاسبية، هنتعلم مع
+
+22
+00:01:46,440 --> 00:01:49,080
+بعض كيف ممكن نتاخد قرارات إدارية حاسمة بناء عن
+
+23
+00:01:49,080 --> 00:01:52,440
+المعلومات اللي أمامنا، إذا كان في انحرافات في
+
+24
+00:01:52,440 --> 00:01:55,900
+العمل المحاسبي، يعني شغل المحاسب، كيف ممكن إحنا
+
+25
+00:01:55,900 --> 00:01:59,620
+نكتشفها، هندرس أنواع مفصلة من التكاليف، إنا
+
+26
+00:01:59,620 --> 00:02:03,420
+chapter كامل عن التكاليف، هنتعلم مع بعض كيف يتم
+
+27
+00:02:03,420 --> 00:02:07,510
+إعداد الموازنات التشغيليةوالموازنات الـ Minor هذه
+
+28
+00:02:07,510 --> 00:02:12,390
+بتختلف عن الموازنات اللي أخدناها في مصراق الإدارة
+
+29
+00:02:12,390 --> 00:02:15,030
+المالية اللي هي الموازنة النقدية التقديرية بتختلف
+
+30
+00:02:15,030 --> 00:02:22,230
+عنها هنتعرف على أسعار التحويل ماشي كيف سوف يتم شرح
+
+31
+00:02:22,230 --> 00:02:24,750
+المادة أول حاجة عن طريق ال lecture أو عن طريق
+
+32
+00:02:24,750 --> 00:02:30,570
+المحاضرة هيكون عندنا عرض LCD إن شاء الله هنزل
+
+33
+00:02:30,570 --> 00:02:34,050
+العرض على الصفحة الشخصية بتاعة الميسهيكون عندنا
+
+34
+00:02:34,050 --> 00:02:37,310
+مناقشة جامعية وهذا الكلام مهم لإتراء المعلومات،
+
+35
+00:02:37,310 --> 00:02:40,910
+هيكون عندنا تطبيقات، هيكون عندنا إيش؟ section أو
+
+36
+00:02:40,910 --> 00:02:46,670
+تطبيقات، إيش اسمه للكتاب؟ اسم المحاسبة الإدارية،
+
+37
+00:02:46,670 --> 00:02:51,750
+موجود اسمه وتفاصيله أمامك في الوصف، أي كتاب آخر
+
+38
+00:02:51,750 --> 00:02:55,430
+للمحاسبة الإدارية أو مواقع الانترنت برضه بتفيدني
+
+39
+00:02:55,430 --> 00:03:00,150
+في إتراء معلوماتعشان ننجح نتفوق في المادة هذه
+
+40
+00:03:00,150 --> 00:03:02,670
+ونحصل أعلى الدرجات وهو هذا المتوقع منكم إن شاء
+
+41
+00:03:02,670 --> 00:03:06,290
+الله لأن جميعكم متميزين ما شاء الله متفوقين لازم
+
+42
+00:03:06,290 --> 00:03:11,410
+نحضر المحاضرات لازم نحضريش المحاضرات في فرق بين
+
+43
+00:03:11,410 --> 00:03:14,490
+الطالب اللي عندها عذر وبتعتذر عن المحاضرة بنحسب
+
+44
+00:03:14,490 --> 00:03:18,730
+اللي حضور أو إنه هي مالهاش دعوة أو مطنشة أو مظهرة
+
+45
+00:03:18,730 --> 00:03:23,010
+لمبلأ برضه هيأثر عليها بشكل سلبي في الدرجات إذا
+
+46
+00:03:23,010 --> 00:03:27,300
+لازم نحضر المحاضرات لأن المادة هذه عاملةلازم نحضر
+
+47
+00:03:27,300 --> 00:03:31,780
+section المادة و ياريت نحضر قبل المحاضرة، ياريت
+
+48
+00:03:31,780 --> 00:03:36,360
+نطلع على الكتاب أو على الفصل قبل إيش بدأ المحاضرة،
+
+49
+00:03:36,360 --> 00:03:38,900
+هيكون عندنا sheet ان شاء الله، المادة هذي عملي،
+
+50
+00:03:38,900 --> 00:03:42,900
+معناها فيها إليها sheet، هيكون عندنا quizات، هيكون
+
+51
+00:03:42,900 --> 00:03:46,620
+عندنا إيش quizات، فاخد بالك كل ما ضاع عليك quiz،
+
+52
+00:03:46,620 --> 00:03:50,760
+الدرجات هتنزل، ماشي؟ لإن و أنت مش مجددا quiz، من
+
+53
+00:03:50,760 --> 00:03:55,490
+أين هنجيبلك درجات؟ فاخد بالك من حتة ال quizاتهيكون
+
+54
+00:03:55,490 --> 00:03:59,550
+ارقم عند جميع الدرجة ان شاء الله سنقسمهم قسميا 60
+
+55
+00:03:59,550 --> 00:04:05,790
+درجة نهائي و 40 نصفي الدرجات أو سياسة الدرجات
+
+56
+00:04:05,790 --> 00:04:13,020
+قابلة للتعديل مرنا في عندنا 40% نصفيخمسة وعشر منها
+
+57
+00:04:13,020 --> 00:04:16,160
+إن شاء الله هيكون على امتحان النصفي إن شاء الله
+
+58
+00:04:16,160 --> 00:04:20,380
+هنحدد جزء من بعض هيكون داخل في النصفي وبعد ذلك
+
+59
+00:04:20,380 --> 00:04:23,360
+هيظل عندنا خمس عشر، خمس عشر زاد خمس عشر ياربعين
+
+60
+00:04:23,360 --> 00:04:28,280
+الخمس عشر هذه هتكون ال section حضور المحاضرة،
+
+61
+00:04:28,280 --> 00:04:32,460
+المشاركة، التفاعل، النشاط، الكوزات هذه الاشي خمس
+
+62
+00:04:32,460 --> 00:04:37,800
+عشر درجة في أمامنا على وصف المادة في أمامنا جدول
+
+63
+00:04:37,800 --> 00:04:39,840
+موزع فيه
+
+64
+00:04:42,400 --> 00:04:45,880
+المادة السبوع الأول إيش راح ناخد لسبوع التاني
+
+65
+00:04:45,880 --> 00:04:49,980
+لسبوع التالت الرابع لغاية لسبوع الخامس عشر لغاية
+
+66
+00:04:49,980 --> 00:04:53,580
+لسبوع الخامس عشر هذه المواضيع اللي احنا ندرسها و
+
+67
+00:04:53,580 --> 00:04:57,900
+نتطرقلها ان شاء الله خلال الأربع أشهر القادمة بعد
+
+68
+00:04:57,900 --> 00:05:02,180
+هيك بيجينا اللي هي وسائل الاتصال في المصر عندك رقم
+
+69
+00:05:02,180 --> 00:05:06,180
+الجامعة تمانية
+
+70
+00:05:06,180 --> 00:05:10,620
+و عشرين اتنين و تلاتين ألف بردب عليك ال machine
+
+71
+00:05:13,180 --> 00:05:17,160
+بقولك ادخل الرقم بتحط سلة 2552 اللي هو رقم المكتب
+
+72
+00:05:17,160 --> 00:05:20,000
+إذا انجدش رقم الجامعة الإسلامية صلحوه عنكوا لو
+
+73
+00:05:20,000 --> 00:05:24,360
+سمحتوا 2832000
+
+74
+00:05:24,360 --> 00:05:28,080
+إذا 2832000
+
+75
+00:05:28,080 --> 00:05:35,000
+برد عليك ال machine بتدخلي 2552 عندك ال email عندك
+
+76
+00:05:35,000 --> 00:05:40,980
+رقم الجوال عندك حسابي على ال face عندك أيضا صفحة
+
+77
+00:05:40,980 --> 00:05:45,410
+الشخصية هتكون موجودة ان شاء اللهأخر حاجة عندنا في
+
+78
+00:05:45,410 --> 00:05:49,750
+وصف المادة هي الساعات المكتبية اللي هي الساعات
+
+79
+00:05:49,750 --> 00:05:52,370
+اللي بكون موجودة أنا فيها في المكتب تبعي طبعا كلكم
+
+80
+00:05:52,370 --> 00:05:54,950
+عارفين وين المكتب لأنه عنده سنة تالتة أو سنة رابعة
+
+81
+00:05:54,950 --> 00:06:08,710
+هحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحنحن
+
+82
+00:06:11,700 --> 00:06:15,540
+عشان ننجح في المادة هذه لازم نجتهد، لازم نحتر،
+
+83
+00:06:15,540 --> 00:06:18,780
+لازم يكون هنا حماس للحضور، ما نجيش غصب عنها، نجي
+
+84
+00:06:18,780 --> 00:06:23,060
+إحنا إيش متحمسين طبعا تم وضع المادة هذه قصدا
+
+85
+00:06:23,060 --> 00:06:25,600
+الساعة تمانية لأنها عملي، هي كان معناها الساعة
+
+86
+00:06:25,600 --> 00:06:28,540
+واحدة، فانا راح اتغيرتها، جبتها الساعة تمانية عشان
+
+87
+00:06:28,540 --> 00:06:32,980
+انها عملي، ماشي، فالعمل يبدو الواحد يكون صاحي
+
+88
+00:06:32,980 --> 00:06:37,100
+ومنتبه و لسه مافيش عنده زخم في المعلومات، في أي
+
+89
+00:06:37,100 --> 00:06:42,190
+سؤال أو استفسار؟ في أي سؤال؟كيف كان درجاتك الفصل
+
+90
+00:06:42,190 --> 00:06:46,690
+الماضي؟ الحمد لله الحمد لله، في حد كان معتقد؟ أو
+
+91
+00:06:46,690 --> 00:06:51,830
+شعر بالصدمة؟ مين إجته صدمة من درجاته؟ أيه دلال؟ لا
+
+92
+00:06:51,830 --> 00:06:55,530
+يا ميس الحمد لله طب الحمد لله، غدير؟ الحمد لله
+
+93
+00:06:55,530 --> 00:06:58,730
+الحمد لله، أنا صدمتي ولا الحمد لله مشت الأمور؟
+
+94
+00:06:58,730 --> 00:07:05,350
+صدمة الحمد لله وخلاص، دوم الحمد لله ماشي ان شاء
+
+95
+00:07:05,350 --> 00:07:08,390
+الله في المادة هذه الدرجات ما تصدمكوش تجيبوا درجات
+
+96
+00:07:08,390 --> 00:07:12,800
+عالية ان شاء اللهأي سؤال يا وستفسار؟ طب اليوم عشان
+
+97
+00:07:12,800 --> 00:07:15,800
+اللقاء اللي .. اللقاء الأول مش راح ناخد .. مش
+
+98
+00:07:15,800 --> 00:07:18,200
+هنبدأ في المادة اليوم إن شاء الله، بس اللقاء
+
+99
+00:07:18,200 --> 00:07:23,240
+ترحيبي، هنبدأ بشكل أساسي يوم الإتنين إن شاء الله،
+
+100
+00:07:23,240 --> 00:07:28,180
+ماشي، و السبت القادم هبدأ أخد حدود غيابي، تكونوا
+
+101
+00:07:28,180 --> 00:07:30,920
+خلاصة و تسجلوا ورتبطوا أمكم، في أي سؤال يا
+
+102
+00:07:30,920 --> 00:07:34,080
+وستفسار؟ أي سؤال؟ يعطيكوا العافية
+
diff --git a/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/S2DPfT2EqqM_raw.srt b/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/S2DPfT2EqqM_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..8ee10a9892f5e4f69b706ed7960d0089881e7db1
--- /dev/null
+++ b/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/S2DPfT2EqqM_raw.srt
@@ -0,0 +1,1340 @@
+1
+00:00:20,810 --> 00:00:23,270
+أعوذ بالله السمعين وعيبن الشيطان الرجيم بسم الله
+
+2
+00:00:23,270 --> 00:00:26,010
+الرحمن الرحيم الحمد لله والصلاة والسلام على
+
+3
+00:00:26,010 --> 00:00:29,950
+المصطفى الأمين سيدنا محمد وعلى آله ومن سرعه على
+
+4
+00:00:29,950 --> 00:00:32,290
+جنب الإحسان والدين في البداية السلام عليكم ورحمة
+
+5
+00:00:32,290 --> 00:00:36,030
+الله كيف حالكوا؟ كيف أصبحتوا اليوم ان شاء الله
+
+6
+00:00:36,030 --> 00:00:39,610
+كويسين؟المحاضرة الماضية انهينا مع بعض انحراف
+
+7
+00:00:39,610 --> 00:00:42,950
+المواد الخامة وقلنا يا غدير إله حالتين حالت أن
+
+8
+00:00:42,950 --> 00:00:46,450
+الكيمية المشترة هي المستعملة و الحالة التانية أني
+
+9
+00:00:46,450 --> 00:00:50,150
+أنا أشتري كمية وماستعملهاش كلها و بعد ذلك أنخدنا
+
+10
+00:00:50,150 --> 00:00:53,850
+انحراف الأجور فيه عنا سؤال بطلح نفسه ما هي أسباب
+
+11
+00:00:53,850 --> 00:00:56,970
+انحراف الأجور، تفضلي يا هودة
+
+12
+00:01:01,310 --> 00:01:04,650
+واحد عدم الدقة في حساب الزمن مافي دقة في حساب
+
+13
+00:01:04,650 --> 00:01:08,070
+الزمن القطعة بدها تلت ساعات أنا بروح كاتبة ساعتين
+
+14
+00:01:08,070 --> 00:01:13,270
+مثلا اتنين عدم توفير بعض عناصر الانتاج بعض عناصر
+
+15
+00:01:13,270 --> 00:01:15,650
+الانتاج زي المواد الخمس متوفرة فشه طبيعي ان هو ده
+
+16
+00:01:15,650 --> 00:01:19,450
+هيأخرنا تلتة تغيير وسائل الانتاج تغيير وسائل
+
+17
+00:01:19,450 --> 00:01:22,710
+الانتاج وتخيل تكنولوجيا جديدة أربع عدم استيعاب
+
+18
+00:01:22,710 --> 00:01:26,270
+كافة العمليات الانتاجية من قبل العمل عدم أخذ
+
+19
+00:01:26,270 --> 00:01:31,630
+العمليات الانتاجية كلها بعين الاعتبار خمسةعدم
+
+20
+00:01:31,630 --> 00:01:34,750
+الدقة في حساب الأجر الـ pressure في الزمن هذه عدم
+
+21
+00:01:34,750 --> 00:01:38,030
+كفاءة إدارة الإنتاج في اختيار العاملين وتوزيعهم
+
+22
+00:01:38,030 --> 00:01:41,870
+على العمليات الإنتاجية هذه ممكن نختصرها بانخفاض
+
+23
+00:01:41,870 --> 00:01:48,790
+مهارة العمال بقدرية تأخير الإنتاج أخر نوع عندنا في
+
+24
+00:01:48,790 --> 00:01:52,310
+الانحرافات اللي هي انحراف التكاليف الصناعية
+
+25
+00:01:52,310 --> 00:01:57,530
+التكاليف الصناعية لها نوعين غير مباشرةأما تكاليف
+
+26
+00:01:57,530 --> 00:02:02,350
+متغيرة أو تكاليف ash تابعة دعونا نشوف مع بعض
+
+27
+00:02:02,350 --> 00:02:08,410
+التكاليف المتغيرة فيه إن سؤال عصبورة معطلعته
+
+28
+00:02:08,410 --> 00:02:16,590
+أمامنا عدد الوحدات الإنتاجية عن نوعين أنا خططت
+
+29
+00:02:16,590 --> 00:02:21,870
+أنتج خمسين ألف وحدة كده انتجت خمسة أخرى ده واضح من
+
+30
+00:02:21,870 --> 00:02:26,810
+البداية أنه فيه ash في انحراف في خللفي خروج على
+
+31
+00:02:26,810 --> 00:02:32,270
+الخطة خُد يبالك من الوحدات اللي مكتوبة بعد الرقم
+
+32
+00:02:32,270 --> 00:02:37,190
+بتساعدنا على الحل الصحيح عدد ساعات العمل جداش
+
+33
+00:02:37,190 --> 00:02:43,050
+تلاتين ألف ساعة الأصل إنه إجمالي عدد ساعات العمل
+
+34
+00:02:43,050 --> 00:02:49,290
+تلاتين ألف ساعة في المخطط الكاتب نص ساعة إذا هذه
+
+35
+00:02:49,290 --> 00:02:53,130
+مش هتكون إجمالي هذه هتكون الوحدة فخُد يبالك من
+
+36
+00:02:53,130 --> 00:02:57,950
+الرقميندائما يا أخوات الوحدة بقدرش أشتغل عليها
+
+37
+00:02:57,950 --> 00:03:02,270
+بقدرش أشتغل عن نص لازم أخليها كبيرة يعني لازم
+
+38
+00:03:02,270 --> 00:03:06,730
+أضربها في حاجة عدد ساعات لما الوحدة إلها اسم تاني
+
+39
+00:03:06,730 --> 00:03:10,010
+اللي هو المعدل المياري اللي هو إيش المعدل المياري
+
+40
+00:03:10,010 --> 00:03:16,250
+تكاليف صناعية غير مباشرة متغيرة 320 ألف دولار
+
+41
+00:03:16,250 --> 00:03:20,370
+معناها يا أسمها هادية الإجمالي ولمّا جالنا دولار
+
+42
+00:03:20,370 --> 00:03:24,540
+معناها تكاليف مش عدد ساعتهاعشرة دولار يا اسمها
+
+43
+00:03:24,540 --> 00:03:31,700
+انجمالي ولا واحدة عشرة واحدة حاجة صغيرة لازم تكبر
+
+44
+00:03:31,700 --> 00:03:36,540
+تكلف صينية غير مباشرة تلقاه لحالة مستقلة السؤال
+
+45
+00:03:36,540 --> 00:03:39,660
+احسب ينحرا في التكلف الصينية غير المباشرة متغيرة
+
+46
+00:03:39,660 --> 00:03:43,100
+الرسم اللي أخدناها المحاضرة الماضية تبعت المواد
+
+47
+00:03:43,100 --> 00:03:48,540
+وتبعت الجود هي نفسها مع اختلاف بسيط ادكر يانوى
+
+48
+00:03:48,540 --> 00:03:52,700
+انحرا في التكلف الصينية غير المباشرة متغيرةعندنا
+
+49
+00:03:52,700 --> 00:03:57,080
+تلات أنواع انحراف في الإنفاق اللي هو في التكاليف
+
+50
+00:03:57,080 --> 00:04:01,960
+وانحراف في الكفاءة اللي هي في المهارة، إذا أنواع
+
+51
+00:04:01,960 --> 00:04:07,820
+انحرافات المتغيرة للتكاليف الصناعية انحراف انفاق
+
+52
+00:04:07,820 --> 00:04:12,890
+وانحراف كفاءةماشي، كيف بنحسبهما؟ يمامك على
+
+53
+00:04:12,890 --> 00:04:15,710
+السابورة، على الرسمة، زي ما أخدنا المرة الماضية،
+
+54
+00:04:15,710 --> 00:04:20,170
+فعلي فعلي، فعلي معياري، معياري معياري، تكاليف
+
+55
+00:04:20,170 --> 00:04:25,110
+فعلية، لازم الرقم اللي نكتبه يكون بعده دولار أو
+
+56
+00:04:25,110 --> 00:04:29,250
+دينار، ليش؟ لأنها تكاليفمافيش تكاريف فعلية بالساعة
+
+57
+00:04:29,250 --> 00:04:33,830
+واضح اسمها هاد و بعدين انحراف الانفاق فعلي معياري
+
+58
+00:04:33,830 --> 00:04:38,930
+اللي هي ساعات فعلية في معدل معياري نشوف مع بعض عدد
+
+59
+00:04:38,930 --> 00:04:41,610
+الساعات الفعلية في السؤال
+
+60
+00:04:46,470 --> 00:04:51,190
+عاد السرعات الفعلية تلاتين ألف، إذا أنا ده إجمالي،
+
+61
+00:04:51,190 --> 00:04:55,950
+كتبناها زي ما هي، ماشي، في المعدل اللي هو التكلفة
+
+62
+00:04:55,950 --> 00:05:00,050
+المتغيرة بس المياري، إذا تلاتين ألف في عشرة،
+
+63
+00:05:00,050 --> 00:05:02,390
+مانفعش يا أخوات أقول تلاتين ألف تلاتمائة وعشرين
+
+64
+00:05:02,390 --> 00:05:05,950
+ألف، أنا قاعدة باخترع حاجة جديدة، تلاتين ألف في
+
+65
+00:05:05,950 --> 00:05:07,450
+إيش؟ في عشرة، هيا
+
+66
+00:05:10,380 --> 00:05:13,820
+ساعات معيارية، لو قلنا ساعات معيارية في المعدد
+
+67
+00:05:13,820 --> 00:05:20,040
+المعياري درجة، هقول ساعات معيارية نص في المعدد
+
+68
+00:05:20,040 --> 00:05:26,460
+المعياري عشرة نص في عشرة، خمسة، بالمنطقه بيمكن
+
+69
+00:05:26,460 --> 00:05:32,800
+نقول تلتمية ألف ناقص خمسةلأ، بعدها انتي ناسي حاجة
+
+70
+00:05:32,800 --> 00:05:35,800
+اللي هي الانتاج، عدد الوانتاج إيش، بس خدوا بالك
+
+71
+00:05:35,800 --> 00:05:39,140
+الانتاج الفعلي مش المعياري، فحنقول الساعات
+
+72
+00:05:39,140 --> 00:05:45,520
+المعيارية نص في عدد الوحدات الفعلية في المعدل، هيك
+
+73
+00:05:45,520 --> 00:05:49,580
+بطلع عندي رقم كبير منطقي، بقدر أطلع على راحتي، إذا
+
+74
+00:05:49,580 --> 00:05:53,640
+انه واضح ليش ضربناها، ماقولناش نص ودرينا ماشيين، و
+
+75
+00:05:53,640 --> 00:05:58,190
+أدخل عيدها، خدوا بالك من النقاط هاليتكاليف فعلي
+
+76
+00:05:58,190 --> 00:06:02,850
+ناقص فعلي معياري 320 ناقص تلاتية .. تلاتمية ألف
+
+77
+00:06:02,850 --> 00:06:05,770
+تلعين عشر ألف بالموجب التكاليف إذا كانت بالموجب
+
+78
+00:06:05,770 --> 00:06:11,770
+دائما غير مفضلة تلاتمية ألف ناقص مائتين وخمس سبعين
+
+79
+00:06:11,770 --> 00:06:16,030
+ألف برضه موجب إذا برضه غير مفضلة هذا اسمه الناحية
+
+80
+00:06:16,030 --> 00:06:18,570
+أيد اليمين انحراف المفاق الناحية أيد الشمال انحراف
+
+81
+00:06:18,570 --> 00:06:25,280
+الكفاءة الاتنين سوا انحراف كلواضح؟ خدي بالك
+
+82
+00:06:25,280 --> 00:06:30,740
+الإشارة هذه مش دايما موجب حسب إذا هذا موجب و هذا
+
+83
+00:06:30,740 --> 00:06:35,180
+سالب بتكون هي بالسالب موجب و موجب موجب سالب و سالب
+
+84
+00:06:35,180 --> 00:06:41,860
+بأجمع بس هي سالب بنحط سالب واضح؟ مفضلة، كويس،
+
+85
+00:06:41,860 --> 00:06:50,380
+الحراف مفضلة واضحة ولا أعيدها؟ أعيدها تاني؟ سؤال
+
+86
+00:06:50,380 --> 00:06:52,940
+ما هي أسباب
+
+87
+00:06:55,490 --> 00:07:01,750
+انحراف التكاليف الصناعية المتغيرة ليش يترى بسرعة
+
+88
+00:07:01,750 --> 00:07:06,910
+انحراف؟
+
+89
+00:07:06,910 --> 00:07:17,370
+يكون لدينا مبالغة يكون لدينا إيش؟ مبالغة في صرف
+
+90
+00:07:17,370 --> 00:07:27,080
+التكاليف الصناعية غير المباشرة المتغيرةمما يؤثر ..
+
+91
+00:07:27,080 --> 00:07:31,940
+مما
+
+92
+00:07:31,940 --> 00:07:39,900
+يؤثر بشكل سلبي على الإيرادات لذلك
+
+93
+00:07:39,900 --> 00:07:45,840
+ننصح بالآتي حتى نتجنب الانحراف عشان مايقالش عند
+
+94
+00:07:45,840 --> 00:07:48,320
+انحراف ننصح بالآتي
+
+95
+00:07:53,650 --> 00:07:57,810
+واحد التعظف على أسباب انحرافه ومعالجته، ايش السبب؟
+
+96
+00:07:57,810 --> 00:08:03,390
+واحد التعظف على أسباب انحرافه ومعالجته، شو السبب؟
+
+97
+00:08:03,390 --> 00:08:07,290
+ثمين مراجعة
+
+98
+00:08:07,290 --> 00:08:10,430
+الموازنات، أخدنا في ال chapter الماضي الموازنات،
+
+99
+00:08:10,430 --> 00:08:15,110
+نرجعها، مراجعة تعرف الموازنات من وقت لاخر، نشوف
+
+100
+00:08:15,110 --> 00:08:20,090
+الموازنة، هل قابلة التطبيق، هل فيها خلال؟ تلاتة
+
+101
+00:08:22,400 --> 00:08:25,460
+شكرا يا انتي التعارف عن نقاط القوة والضعف في العمل
+
+102
+00:08:25,460 --> 00:08:31,000
+التعارف عن نقاط القوة والضعف في إيش؟ في العمل
+
+103
+00:08:31,000 --> 00:08:35,460
+التعارف
+
+104
+00:08:35,460 --> 00:08:39,980
+على سبب انحراف؟ ولا اللي جابلها؟ التعارف على سبب
+
+105
+00:08:39,980 --> 00:08:46,420
+انحراف ومعاشرة أدخل
+
+106
+00:08:46,420 --> 00:08:50,780
+يا سبب انحراف تكلفة صناعية غير المباشرة المتغيرة
+
+107
+00:08:53,960 --> 00:08:58,520
+أخر انحراف في هذا الـ chapter ان شاء الله ومعطيته
+
+108
+00:08:58,520 --> 00:09:05,280
+جاهزة معانا انحراف التكاليف الصناعية غير المباشرة
+
+109
+00:09:05,280 --> 00:09:12,240
+التابعة واضح؟
+
+110
+00:09:12,240 --> 00:09:15,260
+عيد؟
+
+111
+00:09:15,260 --> 00:09:18,920
+عيد؟ انحراف التكاليف الصناعية غير المباشرة التابعة
+
+112
+00:09:18,920 --> 00:09:27,910
+نفس الرسمةبس بدنا نشيل ال .. الكلام إذا ناسيه يا
+
+113
+00:09:27,910 --> 00:09:37,930
+أخوات لو سمحتوا اسمولنا نفس الرسمة طبعا
+
+114
+00:09:37,930 --> 00:09:41,850
+تابتة مش متغيرة في حاجات مشتركة بينهم حدال
+
+115
+00:10:28,830 --> 00:10:31,770
+طبعا تنسيش تكتب انحراف التكاليف الصناعي غير
+
+116
+00:10:31,770 --> 00:10:36,030
+المباشرة التابعة عنوان الرسمة بيكون عندنا نوعين
+
+117
+00:10:36,030 --> 00:10:43,950
+انفاق وحجم وكل نبدأ
+
+118
+00:10:43,950 --> 00:10:49,650
+نحل إذا
+
+119
+00:10:49,650 --> 00:10:56,490
+انحراف انفاق وحجم مش انفاق وكفاءة انفاق وكفاءة في
+
+120
+00:10:56,490 --> 00:11:17,390
+المتغيرةانفقوا حجم في التابعة يالا
+
+121
+00:11:17,390 --> 00:11:22,170
+نعود سهلة جداش تكاليفك الفعالية التابعة في
+
+122
+00:11:22,170 --> 00:11:23,490
+السعودية 550
+
+123
+00:11:27,600 --> 00:11:30,540
+تسعة و تسعة و تسعة و تسعة و تسعة و تسعة و تسعة و
+
+124
+00:11:30,540 --> 00:11:31,300
+تسعة و تسعة و تسعة و تسعة و تسعة و تسعة و تسعة و
+
+125
+00:11:31,300 --> 00:11:33,700
+تسعة و تسعة و تسعة و تسعة و تسعة و تسعة و تسعة و
+
+126
+00:11:33,700 --> 00:11:35,740
+تسعة و تسعة و تسعة و تسعة و تسعة و تسعة و تسعة و
+
+127
+00:11:35,740 --> 00:11:38,740
+تسعة و تسعة و تسعة و تسعة و تسعة و تسعة و تسعة و
+
+128
+00:11:38,740 --> 00:11:40,160
+تسعة و تسعة و تسعة و تسعة و تسعة و تسعة و تسعة و
+
+129
+00:11:40,160 --> 00:11:41,660
+تسعة و تسعة و تسعة و تسعة و تسعة و تسعة و تسعة و
+
+130
+00:11:41,660 --> 00:11:49,660
+تسعة و تسعة و تسعة و تسعة و تسعة و تسعة
+
+131
+00:11:49,660 --> 00:11:52,600
+و تسعة و
+
+132
+00:11:55,620 --> 00:11:58,360
+ساعاتها الفئرانية تلاتين ألف المعدد المعياري
+
+133
+00:11:58,360 --> 00:12:11,660
+خمستاشر أربعين وخمسين ألف لأ
+
+134
+00:12:11,660 --> 00:12:16,140
+هذه معلش نسيت أغيرها أنا ساعات معياري أه هذه
+
+135
+00:12:16,140 --> 00:12:22,880
+نغيرها معلش ساعات
+
+136
+00:12:22,880 --> 00:12:29,430
+معياري الإنتاج المعياريساعات معيارية للإنتاج
+
+137
+00:12:29,430 --> 00:12:35,590
+المعياري هل اتغلقت يا أخوتي عوض
+
+138
+00:12:35,590 --> 00:12:39,570
+معنا الساعة ساعات معيارية للإنتاج المعياري نص
+
+139
+00:12:39,570 --> 00:12:43,730
+مضمونها بالخمسين ألف الكمية بتطلع عندي خمس و عشرين
+
+140
+00:12:43,730 --> 00:12:49,650
+ألف لأ لسه اه لأ هي النص في خمسين ألف خمس تلاف
+
+141
+00:12:49,650 --> 00:12:53,130
+خمسين او .. خمسين يعني اذا مسألتي انا سألتك اه طب
+
+142
+00:12:53,130 --> 00:12:57,700
+حكولي أنه مافيش zero oneأنتوا الحركة عرفتوا؟ ما
+
+143
+00:12:57,700 --> 00:13:02,300
+شاء الله عدلنا لإنك لما قعدت تسأل تفضلي ان خمستاشر
+
+144
+00:13:02,300 --> 00:13:07,000
+بتطلع تلاتمية و خمسة و سبعين قاعدة عزيزي ان انا مش
+
+145
+00:13:07,000 --> 00:13:13,360
+واضحة لحظة نظبط تلاتمية و خمسة و سبعين قاعدة شكرا
+
+146
+00:13:13,360 --> 00:13:16,440
+يا عزيزي السؤال في حاجة بالساعد كتير في أنه حالك
+
+147
+00:13:16,440 --> 00:13:21,840
+صح تقارب ايوة تلاتمية و تسعين قريبا مش تقارب معانا
+
+148
+00:13:21,840 --> 00:13:29,160
+جان بعض حوالين بعض شكرا يا عزيزيهو ده الشوة ساعات
+
+149
+00:13:29,160 --> 00:13:32,780
+.. ساعات تقري الإنتاج الفعلي اللي هي نص بس راح
+
+150
+00:13:32,780 --> 00:13:37,560
+نضربها في الإنتاج الفعلي اللي هو خمسة و خمسين آل
+
+151
+00:13:37,560 --> 00:13:43,180
+ترب بالمعدل اللي هي عشرة خمسنا أو خمستاشر المعدل
+
+152
+00:13:43,180 --> 00:13:47,200
+عشرة للمتغير فخمستاشر، كدهش النتج؟ طبعا احنا
+
+153
+00:13:47,200 --> 00:13:53,200
+اربعمية و اتناشر اربعمية و خمسمية خمسمية
+
+154
+00:13:57,960 --> 00:14:03,940
+لدي إحساس إن هناك طلبات مش فاهمين حاجة أعيد تاني
+
+155
+00:14:03,940 --> 00:14:07,040
+قوانين
+
+156
+00:14:07,040 --> 00:14:10,340
+بنكتبها وبنطبقها التكليف الفعلية مشتركة بين
+
+157
+00:14:10,340 --> 00:14:15,780
+التكليف المباشر والمتغير مشتركة في الحل لكن الأقام
+
+158
+00:14:15,780 --> 00:14:20,880
+مختلفة هاي وهايتكاليف الصناعي غير المباشرة متغيرة
+
+159
+00:14:20,880 --> 00:14:22,720
+تلاتين .. تلاتمية و عشرين ألف هذه إحنا مانعش
+
+160
+00:14:22,720 --> 00:14:26,540
+حللناها قبل شوية إحنا في التابعة تلاتمية و جداشر
+
+161
+00:14:26,540 --> 00:14:30,100
+تلاتمية و تسعين كتبناها تكليف هي أخد بقاعد دايما
+
+162
+00:14:30,100 --> 00:14:34,100
+بعدها دولار مابتديش بالساعة كيف تكلف بالساعة
+
+163
+00:14:34,100 --> 00:14:38,520
+تلاتمية و تسعين ألف دولار كتبناها ساعات معيارية
+
+164
+00:14:38,520 --> 00:14:45,260
+لإنتاج المعياري في المعدل المعياري ساعات
+
+165
+00:14:45,260 --> 00:14:51,790
+معيارية هاي عرض الساعاتقداش المعياري منها؟ نص، ده
+
+166
+00:14:51,790 --> 00:14:55,990
+مفهش أقول نص في المعادل المعياري خمستاشر، مفهش،
+
+167
+00:14:55,990 --> 00:15:01,110
+لأ، غلطت، نص في خمستاشر ده قمص غنون، سبعة و نص،
+
+168
+00:15:01,110 --> 00:15:04,510
+فلازم أضربها في كمية الاش حسب هذه الكمية
+
+169
+00:15:04,510 --> 00:15:10,390
+المعيارية، نص في خمسين في اش في خمستاشرساعات معينة
+
+170
+00:15:10,390 --> 00:15:14,970
+للإنتاج الفعلي نفس الجثة نص بس إنتاج فعلي في 55 في
+
+171
+00:15:14,970 --> 00:15:19,670
+جداش في 15 الحاجة اللي بتخليني أشعر أني حل سليم
+
+172
+00:15:19,670 --> 00:15:25,470
+اللي هي تقارب النتاج لأ
+
+173
+00:15:25,470 --> 00:15:28,970
+نفس الرسمة بس القوانين اختلفت التاب ده المتغيرة
+
+174
+00:15:28,970 --> 00:15:35,750
+تعالوا نطلع نتاج يلا يا راضية راضي الله عنكي 390
+
+175
+00:15:35,750 --> 00:15:43,200
+ناقصهذه بالموجة حلوة
+
+176
+00:15:43,200 --> 00:15:51,140
+ولا وحشة؟ وحش غير مفضلة شكرا يا راضية ها يا مصطفى
+
+177
+00:15:51,140 --> 00:15:57,560
+ألف
+
+178
+00:15:57,560 --> 00:16:04,820
+و خمسمية؟ أيوة، لازم أعطينا رقم هذا؟ ايوة، لازم
+
+179
+00:16:04,820 --> 00:16:06,860
+أعطينا رقم هذا؟ ايوة، لازم أعطينا رقم هذا؟ ايوة،
+
+180
+00:16:06,860 --> 00:16:07,620
+لازم أعطينا رقم هذا؟ ايوة، لازم أعطينا رقم هذا؟
+
+181
+00:16:07,620 --> 00:16:08,200
+ايوة، لازم أعطينا رقم هذا؟ ايوة، لازم أعطينا رقم
+
+182
+00:16:08,200 --> 00:16:08,200
+هذا؟ ايوة، لازم أعطينا رقم هذا؟ ايوة، لازم أعطينا
+
+183
+00:16:08,200 --> 00:16:12,720
+رقم هذا؟ ايوة، لازم أعطينا رقالان النقطة الحاسمة
+
+184
+00:16:12,720 --> 00:16:16,360
+موجب
+
+185
+00:16:16,360 --> 00:16:27,760
+وسالب طرح طرح طرح طرح طرح طرح طرح
+
+186
+00:16:27,760 --> 00:16:38,220
+طرح طرح طرح طرح طرح طرح طرح طرح طرح طرح طرح طرح
+
+187
+00:16:38,220 --> 00:16:38,240
+طرح طرح طرح طرح طرح طرح طرح طرح طرح طرح طرح طرح
+
+188
+00:16:38,240 --> 00:16:38,240
+طرح طرح طرح طرح طرح طرح طرح طرح طرح طرح طرح طرح
+
+189
+00:16:38,240 --> 00:16:38,500
+طرح طرح طرح طرح طرح طرح طرح طرح طرح طرح طرح طرح
+
+190
+00:16:38,500 --> 00:16:38,540
+طرح طرح طرح طرح طرح طرح طرح طرح طرح طرح طرح طرح
+
+191
+00:16:38,540 --> 00:16:38,580
+طرح طرح طرح
+
+192
+00:16:42,100 --> 00:16:47,500
+واضحة؟ إذا كتبت قوانين وتطبيقها بشكل مباشر مين
+
+193
+00:16:47,500 --> 00:16:52,060
+معناها مفضل؟ مين معناها إيش؟ مفضل يعني كويس، يعني
+
+194
+00:16:52,060 --> 00:17:00,040
+حلو إيش يعني مفضل، كويس، حلو؟ يعني التكاليف
+
+195
+00:17:00,040 --> 00:17:06,080
+الفعلية أقل من المعيارية التكاليف الفعلية أقل من
+
+196
+00:17:06,080 --> 00:17:07,960
+إيش؟ من المعيارية
+
+197
+00:17:10,390 --> 00:17:18,050
+في حد عنده مشكلة عيد تانى؟ في حد عنده مشكلة؟
+
+198
+00:17:18,050 --> 00:17:23,190
+في حد عنده مشكلة؟ يلا الآن مع السؤال دبون حل
+
+199
+00:17:23,190 --> 00:17:26,780
+السؤال الأول في ال sheetيعني بتقولي اعططوني الرقم
+
+200
+00:17:26,780 --> 00:17:30,180
+هي هم جمعين هي الاشخاص اللي اقول انا سالب هي هم
+
+201
+00:17:30,180 --> 00:17:34,300
+جمعين لإنه بالسلب بتطلع 52500 بالموجب يعني غير
+
+202
+00:17:34,300 --> 00:17:40,260
+مفضل الجواب يكون انت عم بقى اتأكد اللي بقى انت
+
+203
+00:17:40,260 --> 00:17:45,040
+مستحيل اقل من نص سبعة تانية سالب سبعة تانية تانية
+
+204
+00:17:45,040 --> 00:17:47,160
+تانية تانية تانية تانية تانية تانية تانية تانية
+
+205
+00:17:47,160 --> 00:17:47,420
+تانية تانية تانية تانية تانية تانية تانية تانية
+
+206
+00:17:47,420 --> 00:17:47,700
+تانية تانية تانية تانية تانية تانية تانية تانية
+
+207
+00:17:47,700 --> 00:17:48,260
+تانية تانية تانية تانية تانية تانية تانية تانية
+
+208
+00:17:48,260 --> 00:17:48,700
+تانية تانية تانية
+
+209
+00:17:52,270 --> 00:18:17,650
+مش يمسي خمستاشر ألف ناقص سالب سالب سالب
+
+210
+00:18:17,650 --> 00:18:21,170
+سالب سالب سالب سالب سالب سالب سالب سالب سالب سالب
+
+211
+00:18:21,170 --> 00:18:21,310
+سالب سالب سالب سالب سالب سالب سالب سالب سالب سالب
+
+212
+00:18:21,310 --> 00:18:21,310
+سالب سالب سالب سالب سالب سالب سالب سالب سالب سالب
+
+213
+00:18:21,310 --> 00:18:21,310
+سالب سالب سالب سالب سالب سالب سالب سالب سالب سالب
+
+214
+00:18:21,310 --> 00:18:21,310
+سالب سالب سالب سالب سالب سالب سالب سالب سالب سالب
+
+215
+00:18:21,310 --> 00:18:21,310
+سالب سالب سالب سالب سالب سالب سالب سالب سالب سالب
+
+216
+00:18:21,310 --> 00:18:21,490
+سالب سالب سالب سالب سالب سالب
+
+217
+00:18:24,380 --> 00:18:28,540
+تفضل يا عم، دا أيه ال sheet؟ طبعا لغاية ها ..
+
+218
+00:18:28,540 --> 00:18:33,500
+لغاية الشريحة هذه فيها
+
+219
+00:18:33,500 --> 00:18:37,500
+ده الشبطة يعني يوم السبت يا بنبدأ بحاجة جديدة يا
+
+220
+00:18:37,500 --> 00:18:41,540
+بنشوف كيف ان شاء الله واضح؟ طب فيه دا يد في الشبطة
+
+221
+00:18:41,540 --> 00:18:45,900
+الكلام؟ إيش
+
+222
+00:18:45,900 --> 00:18:50,760
+طالب مني أول حاجة في ال sheet؟ هي إسرة أخدت ال
+
+223
+00:18:50,760 --> 00:18:57,080
+sheet تبعي، مش مش؟بنعطيكي يا auntie أظن هذا هو إيش
+
+224
+00:18:57,080 --> 00:19:01,360
+أول حاجة في ال sheet؟ أه طالب التابعة ده الكل
+
+225
+00:19:01,360 --> 00:19:04,700
+تركيزك يكون على التابعة ممكن تمسح الأرقام بس يا
+
+226
+00:19:04,700 --> 00:19:12,060
+إسراء الحمد لله ماشي كإنما أنت مسدقة؟ بينك و بين
+
+227
+00:19:12,060 --> 00:19:13,360
+وطار ولا حاجة؟
+
+228
+00:19:37,540 --> 00:19:45,160
+هذا ال sheet قدش رقمه يا أخوان؟ تمانين؟ شايفين
+
+229
+00:19:45,160 --> 00:19:49,320
+أه؟
+
+230
+00:19:49,320 --> 00:19:59,760
+هاي ال sheet تبع إسراء إسراء
+
+231
+00:19:59,760 --> 00:20:05,180
+هاي مكتوب هاي طالع طالع يا عزيزي أه أه لإنه طالع
+
+232
+00:20:05,180 --> 00:20:06,760
+أمامك على الصابورة عشان نغلب حالنا
+
+233
+00:20:24,540 --> 00:20:33,860
+من خلص رسم؟ انا انا ممتاز باقية الشعب حاولي تهلمي
+
+234
+00:20:33,860 --> 00:20:37,180
+ايدك على السرعة تودي على السرعة
+
+235
+00:21:16,930 --> 00:21:26,710
+هتبدأي في التابتة؟ ماشي، تفضلي يا
+
+236
+00:21:26,710 --> 00:21:32,570
+عزيزي و أنتي بتحلي ترفعي صوتك، و تتصوري نفسك قاعدة
+
+237
+00:21:32,570 --> 00:21:36,710
+بتشرحي عندي، عساس لو في أي طلبة، فاتحة، حاجة، تكون
+
+238
+00:21:36,710 --> 00:21:37,030
+معانا
+
+239
+00:21:41,400 --> 00:21:45,560
+لازم نكتب الأنواع انحققها في انفاق، انحققها في حجم
+
+240
+00:21:45,560 --> 00:21:53,280
+ممتازة
+
+241
+00:21:53,280 --> 00:22:03,340
+ممتازة
+
+242
+00:22:11,420 --> 00:22:17,460
+برنامج معدمة لنا يعني ممكن
+
+243
+00:22:17,460 --> 00:22:21,360
+حاجة اتلقيت التكاريث الفعالية بالسؤال عندي في
+
+244
+00:22:21,360 --> 00:22:32,040
+التكاريث هنا يتابع 60 ألف هحبها عندي
+
+245
+00:22:32,040 --> 00:22:35,760
+أعدد ساعات لحظة لحظة لحظة لحظة لحظة لحظة لحظة لحظة
+
+246
+00:22:35,760 --> 00:22:36,020
+لحظة لحظة لحظة لحظة لحظة لحظة لحظة لحظة لحظة لحظة
+
+247
+00:22:36,020 --> 00:22:37,000
+لحظة لحظة لحظة لحظة لحظة لحظة لحظة لحظة لحظة لحظة
+
+248
+00:22:37,000 --> 00:22:37,420
+لحظة لحظة لحظة لحظة لحظة لحظة لحظة لحظة لحظة لحظة
+
+249
+00:22:37,420 --> 00:22:43,780
+لحظة لحظة لحالسؤال هذا مش أجلب، احنا اتعودنا فعلي
+
+250
+00:22:43,780 --> 00:22:47,380
+مخطط، السؤال هذا جاي مخطط فعلي، لان ده ديش بتطلع
+
+251
+00:22:47,380 --> 00:22:59,920
+يسرق تلاقيت
+
+252
+00:22:59,920 --> 00:23:03,300
+عدد ساعات مياري، مانساش المياري؟ لان شوي شوي،
+
+253
+00:23:03,300 --> 00:23:07,040
+اطولي بالك انتي، ليش كتبنا التكاليف الفعلي 590
+
+254
+00:23:07,040 --> 00:23:14,500
+يعني اللي هو دمشق 60؟أيوة لأ أنا فعلي هو مش هقلبها
+
+255
+00:23:14,500 --> 00:23:18,400
+بس تفضلي أيوة كاملة هاتبعلي عدد ساعات ميارية
+
+256
+00:23:18,400 --> 00:23:23,460
+للإنتاج المياري عندي عدد الساعات تلاتة من عشرة
+
+257
+00:23:23,460 --> 00:23:30,700
+هضربها بالكمية اللي هي تلات تلات تلات تلات تلات
+
+258
+00:23:30,700 --> 00:23:37,170
+تلات ضرب المعدن المياريعندي في التكاريف الشابعة
+
+259
+00:23:37,170 --> 00:23:41,770
+هعمل انه هاخد الرقم زي ما هو MS انت فاكر يا عزيزي
+
+260
+00:23:41,770 --> 00:23:46,090
+فعلا؟ لأ يبقى ايش هعمل في المعدل المعياري هاخد
+
+261
+00:23:46,090 --> 00:23:49,590
+ستين ألف و هقسمها لعدد الوحدات اللي هي التلات تلات
+
+262
+00:23:49,590 --> 00:23:56,810
+ستين ألف ضارف ستين ألف على عدد الوحدة التلات تلات
+
+263
+00:23:56,810 --> 00:24:01,690
+محتاج جيب ال GMS جيب ال تكيران
+
+264
+00:24:06,340 --> 00:24:11,220
+استاذة إصلاح كأن الطلبات مظلمين مندهشين في إشي مش
+
+265
+00:24:11,220 --> 00:24:18,020
+واضح يا بنات عشرين ماشي فضلي كاملي بس بدي أطلع من
+
+266
+00:24:18,020 --> 00:24:28,960
+هناك عشرين ستين ع تلاتة بتلع
+
+267
+00:24:28,960 --> 00:24:32,040
+تمنتاشر ألف الجواب النهائي تمنتاشر ألف ولا مية و
+
+268
+00:24:32,040 --> 00:24:33,180
+تمانين مية و تمانين
+
+269
+00:24:44,590 --> 00:24:56,570
+دربت تلاتة من عشرة في تلات ألاف طيب
+
+270
+00:24:56,570 --> 00:25:01,350
+انت لسه في
+
+271
+00:25:01,350 --> 00:25:07,550
+ستين اتلات اتلات اتلات اتلات اتلات
+
+272
+00:25:11,780 --> 00:25:16,520
+فالإنترنت بيحكيلي عدد الساعات المعيارية من الإنتاج
+
+273
+00:25:16,520 --> 00:25:20,680
+الفعلي ضارب المعدل المعياري عدد الساعات المعيارية
+
+274
+00:25:20,680 --> 00:25:30,660
+عندي 21 فده 18 في الإنتاج الفعلي عندي .. الإنتاج
+
+275
+00:25:30,660 --> 00:25:35,440
+الفعلي قدر 4000 ضارب
+
+276
+00:25:35,440 --> 00:25:38,620
+المعدل المعياري اللي هو 60 ألف
+
+277
+00:25:55,260 --> 00:25:59,660
+مائص، مائص، يعني زي ما أحنا قلنا عنها ال خمسمية و
+
+278
+00:25:59,660 --> 00:26:03,500
+تسعين ألف ال ميتين و أربع و عشرين ألف بتطلع يعني
+
+279
+00:26:03,500 --> 00:26:07,020
+أسرع، لأ لأ مش هان هنا أخر واحدة ال ميتين و أربع و
+
+280
+00:26:07,020 --> 00:26:10,800
+عشرين ألف ال ميتين و أربع و عشرين ألف ال ميتين و
+
+281
+00:26:10,800 --> 00:26:13,560
+أربع و عشرين ألف اطلحولها لو سمحتوا
+
+282
+00:26:28,070 --> 00:26:33,430
+خمسمية اتنين وسبعين الف سالب
+
+283
+00:26:33,430 --> 00:26:36,810
+ولا موجب؟ موجب
+
+284
+00:26:46,360 --> 00:26:51,000
+مفضلة، فهذه الإشارة هنا هتكون ثالث، لموجة ثالث كيف
+
+285
+00:26:51,000 --> 00:26:55,740
+هنحسب اليهودة؟ الرقم نفسه، زي ما هو ناقص الرقم زي
+
+286
+00:26:55,740 --> 00:27:02,200
+ما هو واقع ستة ثلاث أربع تماسين وستة وستين، وستة
+
+287
+00:27:02,200 --> 00:27:12,040
+وستين أربع لموجة غير مفضلة شكرا
+
+288
+00:27:12,040 --> 00:27:12,360
+يا عزيزي
+
+289
+00:27:17,040 --> 00:27:23,580
+مين؟ بس ع السريع، ماشي، تفضلي مادلي، ماشي ع السريع
+
+290
+00:27:23,580 --> 00:27:32,200
+عشان بقالينا في محاضرة تانية خلصتوا
+
+291
+00:27:32,200 --> 00:27:40,580
+يا أخوات؟ لو ما خلصتوش ماكنت تاخدوا من بعض طب
+
+292
+00:27:40,580 --> 00:27:44,770
+عن حين انا في تكييف مطرية مافيش فيها أفكارع
+
+293
+00:27:44,770 --> 00:27:57,430
+الصراعي مدلين لو سمحتي خدتي
+
+294
+00:27:57,430 --> 00:28:02,730
+بالك السؤال ايش كاتب مع التعليق بشيء من التفصيل ان
+
+295
+00:28:02,730 --> 00:28:07,890
+انشطت تتفرج فعليا من ال .. من التقاليد الفارغة ..
+
+296
+00:28:07,890 --> 00:28:10,670
+التقاليد .. لأ انت .. انت لأ في المتغيرة اه انا
+
+297
+00:28:10,670 --> 00:28:12,490
+متغيرة ماعشان غير العنوان
+
+298
+00:28:18,620 --> 00:28:20,820
+تكلف الفعلية المطولة كده في السؤال؟ تلاتمائة و
+
+299
+00:28:20,820 --> 00:28:26,840
+أربعين ألف تلاتمائة و أربعين ألف ساعة
+
+300
+00:28:26,840 --> 00:28:30,060
+الفعلية ستة عشر ألف كده شهر نسمة ساعة الفعلية في
+
+301
+00:28:30,060 --> 00:28:37,220
+سؤالك؟ ستة عشر ألف حيها ستة عشر ألف ستة عشر ألف
+
+302
+00:28:37,220 --> 00:28:43,000
+معدل معين ليه؟ عشري عشري تلاتمائة و عشرين ألف
+
+303
+00:28:43,000 --> 00:28:44,600
+تلاتمائة و عشرين ألف
+
+304
+00:28:47,480 --> 00:28:58,160
+ساعة من عشرة ساعة من عشرة ساعة من عشرة ساعة من
+
+305
+00:28:58,160 --> 00:29:02,760
+عشرة ساعة من عشرة ساعة من عشرة ساعة من عشرة ساعة
+
+306
+00:29:02,760 --> 00:29:06,900
+من عشرة ساعة
+
+307
+00:29:06,900 --> 00:29:09,940
+من
+
+308
+00:29:09,940 --> 00:29:14,570
+عشرة ساعة من عشرةEmails بس يعني غلط يعني بس يبقى
+
+309
+00:29:14,570 --> 00:29:18,710
+عادة أرجم على بعضهم بس يعني غلط بتلاحظ أن هو رقمين
+
+310
+00:29:18,710 --> 00:29:25,590
+جراب بس الأخير طلع من بعيد شوية مش
+
+311
+00:29:25,590 --> 00:29:30,290
+قاعدة
+
+312
+00:29:30,290 --> 00:29:33,590
+أنا بساعدكوا بس عشان توصلوا لحل السهل أو الحل
+
+313
+00:29:33,590 --> 00:29:34,770
+الصحيح لكن هي مش قاعدة
+
+314
+00:29:38,540 --> 00:29:51,440
+196 ألف كدهش؟ 196 ألف كدهش؟ 196 ألف كدهش؟
+
+315
+00:29:51,440 --> 00:29:51,440
+196 ألف كدهش؟ 196 ألف كدهش؟ 196 ألف كدهش؟ 196 ألف
+
+316
+00:29:51,440 --> 00:29:51,440
+كدهش؟ 196 ألف كدهش؟ 196 ألف كدهش؟ 196 ألف كدهش؟
+
+317
+00:29:51,440 --> 00:29:51,440
+196 ألف كدهش؟ 196 ألف كدهش؟ 196 ألف كدهش؟ 196 ألف
+
+318
+00:29:51,440 --> 00:29:51,880
+كدهش؟ 196 ألف كدهش؟ 196 ألف كدهش؟ 196 ألف كدهش؟
+
+319
+00:29:51,880 --> 00:29:54,940
+116 ألف كدهش؟ 116 ألف كدهش؟ 116 ألف كدهش؟ 116 ألف
+
+320
+00:29:54,940 --> 00:29:59,000
+كدهش؟ 116 ألف كدهش؟ 116 ألف كدهش؟ 116 ألف كدهش؟
+
+321
+00:29:59,000 --> 00:30:13,520
+116 ألف كدهش؟ 116 ألف كدهش؟ 116 ألف كشكرا شكرا مع
+
+322
+00:30:13,520 --> 00:30:18,400
+التعليق بشيء من التفصيل أنا
+
+323
+00:30:18,400 --> 00:30:26,580
+اللي هاجاوبها السؤال هذا يلا نعلق يلا مما سبق
+
+324
+00:30:26,580 --> 00:30:31,120
+أخديها
+
+325
+00:30:31,120 --> 00:30:36,440
+عادي مما سبق يتضح أن انحراف التكليف الصناعية غير
+
+326
+00:30:36,440 --> 00:30:45,510
+المباشرة متغيرةغير مفضل أي
+
+327
+00:30:45,510 --> 00:30:55,650
+أن المؤسسة لديها مبالغة في صرف التكاليف مما
+
+328
+00:30:55,650 --> 00:31:04,790
+يؤثر بشكل سلبي عليها لذلك ننصح بالآتي واحد
+
+329
+00:31:06,610 --> 00:31:12,070
+التعرف على أسباب هذا الانحراف نين
+
+330
+00:31:12,070 --> 00:31:18,530
+مراجعة موازنة تلاتة ممتازة يا غدير التعرف على نقاط
+
+331
+00:31:18,530 --> 00:31:24,250
+القوة والضعف أي سؤال يا أخوات في المحاضرة اليوم
+
+332
+00:31:24,250 --> 00:31:29,690
+ذكروني أن في في ال sheet بالسؤال في ال sheet
+
+333
+00:31:29,690 --> 00:31:32,670
+بالسؤال في أفكار فهنحلوا مع بعض يوم السبت إن شاء
+
+334
+00:31:32,670 --> 00:31:36,910
+اللهأي سؤال أو استفسار المحاضرة اليوم، أي سؤال،
+
+335
+00:31:36,910 --> 00:31:37,890
+يعطيكوا العافية
+
diff --git a/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/VTOTmfV6dfU.srt b/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/VTOTmfV6dfU.srt
new file mode 100644
index 0000000000000000000000000000000000000000..a120af098c10391a2e455c843666687b3b262de3
--- /dev/null
+++ b/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/VTOTmfV6dfU.srt
@@ -0,0 +1,1349 @@
+1
+00:00:20,890 --> 00:00:23,070
+اعوذ بالله السميع العليم من الشيطان الرجيم .. بسم
+
+2
+00:00:23,070 --> 00:00:25,690
+الله الرحمن الرحيم .. الحمد لله والصلاة والسلام
+
+3
+00:00:25,690 --> 00:00:29,470
+على سيدنا مصطفى الأمين محمد وعلى آله وصحبه
+
+4
+00:00:29,470 --> 00:00:32,970
+أجمعين.. في البداية السلام عليكم ورحمة الله ..
+
+5
+00:00:32,970 --> 00:00:38,210
+كيف حالكم؟ كيف أصبحتُم اليوم؟ بخير إن شاء الله؟
+
+6
+00:00:38,210 --> 00:00:42,330
+زلنا في الموازنات التشغيلية، تعرفنا مع بعض
+
+7
+00:00:42,330 --> 00:00:45,930
+في المحاضرات السابقة عنها، وهي موازنة المبيعات و
+
+8
+00:00:45,930 --> 00:00:48,770
+أخذناها بالتفصيل، وكيف تم إعدادها، و
+
+9
+00:00:48,770 --> 00:00:51,510
+الفرق بين المبيعات بالوحدة والمبيعات بالدولار. بعد
+
+10
+00:00:51,510 --> 00:00:55,510
+ذلك، طرقنا إلى موضوع موازنة المخزون. إذا توقفنا
+
+11
+00:00:55,510 --> 00:00:58,490
+حسب الجدول، عند موازنة شيء على المخزون
+
+12
+00:00:58,490 --> 00:01:01,130
+السلعي. حكينا المخازن لها عدة أنواع، في عندنا مخزون
+
+13
+00:01:01,130 --> 00:01:07,570
+سلعي، ومخزون مواد نصف مصنعة، ومخزون مواد .. تم
+
+14
+00:01:07,570 --> 00:01:12,190
+تصنيعها. والمواد التي تم تصنيعها هي المخزون السلعي.
+
+15
+00:01:12,190 --> 00:01:14,810
+خذوا بالكم، فيه هيجينا قدام كمان مخزون إن شاء الله.
+
+16
+00:01:14,810 --> 00:01:21,770
+فلنبدأ نحن مع أول مخزون. كان عندنا سؤال، أتوقع كان
+
+17
+00:01:21,770 --> 00:01:24,890
+عندنا سؤال لشركة تجارية.
+
+18
+00:01:32,910 --> 00:01:37,090
+شركة الفجر، سياساتها في المخزون السلعي لا تقل عن 25%
+
+19
+00:01:37,090 --> 00:01:42,030
+من مبيعات الشهر التالي.  أعدي موازنة المخزون
+
+20
+00:01:42,030 --> 00:01:44,010
+السلعي. طبعاً موازنة المخزون السلعي من أسهل
+
+21
+00:01:44,010 --> 00:01:49,590
+الموازنات، من أسهلها موازنة
+
+22
+00:01:49,590 --> 00:02:00,510
+المخزون السلعي.  شكل هذا يا أخوات.  نون (أي الزمن) المبيعات
+
+23
+00:02:00,510 --> 00:02:02,070
+خذوا بالكم بالوحدة.
+
+24
+00:02:09,800 --> 00:02:16,260
+نسبة المخزون، موازنة
+
+25
+00:02:16,260 --> 00:02:21,840
+مبيعات المخزون السلعي، موازنة المخزون السلعي، وعطينا
+
+26
+00:02:21,840 --> 00:02:27,580
+نحن،  noon (أي الزمن)، واحد: شهر يناير، فبراير، مارس
+
+27
+00:02:27,580 --> 00:02:33,160
+إلى أربعة أشهر. .. أربعة عشر، كتبناها. أعطينا المبيعات يا
+
+28
+00:02:33,160 --> 00:02:38,200
+سلوى في السؤال، معكِ. ماشي. اه يا غدير.
+
+29
+00:02:45,800 --> 00:02:48,160
+جدا.  الناس بقى؟  حصة واحدة وعشر دقائق.
+
+30
+00:03:05,350 --> 00:03:08,130
+بحكي عن سياسة المخزون السلعي، تقريباً 25% من
+
+31
+00:03:08,130 --> 00:03:12,050
+مبيعات الشهر التالي.  من الشهر الذي يأتي بعد شهر
+
+32
+00:03:12,050 --> 00:03:15,730
+واحد يا هناء؟ شهر اثنين. شهر اثنين، خذي بالكِ.
+
+33
+00:03:15,730 --> 00:03:19,970
+من
+
+34
+00:03:19,970 --> 00:03:26,610
+الشهر الذي يأتي بعد شهر اثنين يا عائشة؟ ثلاثة.
+
+35
+00:03:26,610 --> 00:03:33,460
+من الشهر الذي يأتي بعد شهر ثلاثة؟ أربعة يا مريم. طيب،
+
+36
+00:03:33,460 --> 00:03:36,960
+على الهدف لماذا؟ لأنه في الشهر خمسة آلاف. ربع
+
+37
+00:03:36,960 --> 00:03:40,560
+.. ألفين. ألفين في 25%، ألف وخمسمائة.
+
+38
+00:03:40,560 --> 00:03:43,700
+ألف وخمسمائة. ألف وخمسمائة، ستة آلاف
+
+39
+00:03:43,700 --> 00:03:48,600
+في 25% ألف
+
+40
+00:03:48,600 --> 00:03:49,680
+ومئتين وخمسين. ألف ومئتين
+
+41
+00:03:49,680 --> 00:03:49,760
+وخمسين. ألف ومئتين و
+
+42
+00:03:49,760 --> 00:03:52,000
+خمسين. ألف ومئتين وخمسين. ألف ومئتين و
+
+43
+00:03:52,000 --> 00:03:56,740
+خمسين. ألف ومئتين وخمسين. ألف
+
+44
+00:03:56,740 --> 00:04:01,760
+ومئتين وخمسين. ألف ومئتين وخمسين. ألف ومئتين
+
+45
+00:04:01,760 --> 00:04:07,750
+وخمسة وأربعة وثلاثة في 25%.  أنا أقول: لا آخذ
+
+46
+00:04:07,750 --> 00:04:11,750
+بالي من الرقم. خذي بالكِ، هذه السياسة تتغير، ليست قاعدة
+
+47
+00:04:11,750 --> 00:04:15,530
+ثابتة. يعني، ممكن يقول 25% من نفس الشهر.
+
+48
+00:04:15,530 --> 00:04:19,390
+خلاص، من نفس الشهر: واحد، واحد، اثنين، اثنين،  ممكن يقول
+
+49
+00:04:19,390 --> 00:04:29,270
+الشهر التالي، ممكن يقول بعد شهرين، حسب السؤال.  أعيدها
+
+50
+00:04:29,270 --> 00:04:34,210
+ثانية؟ سهلة؟ إذا، ما قال السؤال؟ أعدي موازنة، المقصود
+
+51
+00:04:34,210 --> 00:04:39,310
+السلعي بحيث لا تقل عن 25% من مبيعات الشهر التالي.
+
+52
+00:04:39,310 --> 00:04:44,010
+نحن الآن في الشهر الثالث، الشهر القادم سيكون شهر
+
+53
+00:04:44,010 --> 00:04:48,350
+أربعة. نجيب مبيعاته، ونضربها في 25%، كما نحن
+
+54
+00:04:48,350 --> 00:04:53,670
+عاملين.  أعيدها؟
+
+55
+00:04:53,670 --> 00:04:55,070
+أعيدها ثانية؟
+
+56
+00:05:10,360 --> 00:05:19,460
+اسمها ماذا؟ الآن يا أخوات، موازنة
+
+57
+00:05:19,460 --> 00:05:23,740
+الإنتاج.  بسبب هذا،  لستُ أعرف، إلا أنني  لستُ  أعلم  كيف أعدّ موازنة
+
+58
+00:05:23,740 --> 00:05:30,340
+الإنتاج،  ظهرتْ معكم هنا؟  ظهرتْ معكم في الـ slide  هنا؟
+
+59
+00:05:30,340 --> 00:05:34,940
+التي هي
+
+60
+00:05:34,940 --> 00:05:37,860
+موازنة الإنتاج، يا عزيزتي. طيب،  الذي عملتها فضل الله
+
+61
+00:05:37,860 --> 00:05:43,660
+سمحتِ.  لا يوجد ضبطٌ  ماشي، نحنُ
+
+62
+00:05:43,660 --> 00:05:46,760
+الآن في موازنة الإنتاج، التي تأتي بعد موازنة المخزون
+
+63
+00:05:46,760 --> 00:05:51,500
+السلعي. كمْ يا هبة؟  موازنة الإنتاج، فضلاً. سؤالٌ
+
+64
+00:05:51,500 --> 00:05:58,620
+يسمع؟
+
+65
+00:05:58,620 --> 00:06:04,300
+يعني ينبغي؟ أول شيء، تساعدنا موازنة الإنتاج على
+
+66
+00:06:04,300 --> 00:06:09,680
+تخطيط تكلفة الإنتاج،  كمْ سيكلفنا الإنتاج؟ 2.
+
+67
+00:06:09,820 --> 00:06:12,920
+تُستخدم هذه المواد لتوقيت عمليات الإنتاج من مختلف
+
+68
+00:06:12,920 --> 00:06:16,360
+الجوانب، أي أنها تعتبر أساسية لبناء وإعداد موازنات
+
+69
+00:06:16,360 --> 00:06:21,100
+مختلفة،  وعناصر تكلفة الإنتاج. رقم 2، ليس فقط في
+
+70
+00:06:21,100 --> 00:06:23,820
+أن موازنة الإنتاج تساعدني في تخطيط تكلفة
+
+71
+00:06:23,820 --> 00:06:28,960
+الإنتاج، بل تساعد أيضاً في تخطيط توقيت الإنتاج. لا يمكن
+
+72
+00:06:28,960 --> 00:06:33,960
+إنتاج رقم 3.  هي حاجة أساسية لموازنات عدة، حاجة
+
+73
+00:06:33,960 --> 00:06:36,400
+أساسية، معناها لا أستطيع جلب الموازنات التي بعدها، والتي
+
+74
+00:06:36,400 --> 00:06:39,860
+يجب أن تكون موجودة، مثل المبيعات، مثل ماذا؟ موازنة أولية
+
+75
+00:06:39,860 --> 00:06:42,220
+..موازنة المواد، والتكاليف الإنتاجية الأولية.
+
+76
+00:06:42,220 --> 00:06:42,260
+..موازنة المواد، والتكاليف الإنتاجية الأولية.
+
+77
+00:06:42,260 --> 00:06:44,120
+..موازنة المواد، والتكاليف الإنتاجية الأولية.
+
+78
+00:06:44,120 --> 00:06:45,100
+..موازنة المواد، والتكاليف الإنتاجية الأولية.
+
+79
+00:06:45,100 --> 00:06:46,780
+..موازنة المواد، والتكاليف الإنتاجية الأولية.
+
+80
+00:06:46,780 --> 00:06:50,200
+..موازنة المواد، والتكاليف الإنتاجية الأولية.
+
+81
+00:06:50,200 --> 00:06:54,720
+..موازنة المواد، والتكاليف الإنتاجية الأولية.
+
+82
+00:06:54,720 --> 00:06:58,940
+..موازنة
+
+83
+00:06:58,940 --> 00:07:01,640
+المواد، والتكاليف الإنتاجية الأولية. ..موازنة
+
+84
+00:07:01,640 --> 00:07:04,080
+المواد، والتكاليف الإنتاجية الأولية. ..موازنة
+
+85
+00:07:10,560 --> 00:07:17,840
+تُعتبر موازنة الإنتاج هي
+
+86
+00:07:17,840 --> 00:07:25,920
+حاجة أساسية لموازنات عدة، كموازنة
+
+87
+00:07:25,920 --> 00:07:31,280
+المواد الأولية، والمخزون السلعي، وسأكتفي بذلك، دلال.
+
+88
+00:07:31,280 --> 00:07:34,700
+كموازنة الشيء الاصطناعي؟ المواد الأولية والمخزون
+
+89
+00:07:34,700 --> 00:07:39,590
+السلعي؟  تخطيط موازنة الإنتاج يا عزيزي، هذا
+
+90
+00:07:39,590 --> 00:07:43,850
+أساس خاطئ، كانت موازنة المواد الأولية وقول عمال، والتكلفة
+
+91
+00:07:43,850 --> 00:07:46,750
+الإنتاجية. .. ما كان؟ أمامك على السبورة، موازنة
+
+92
+00:07:46,750 --> 00:07:49,670
+المخزون السلعي معتمدة على المبيعات،  وليس على الإنتاج.
+
+93
+00:07:49,670 --> 00:07:54,010
+الأرقام المكتوبة أمامنا، مبيعات،  ليست إنتاجاً، هذا
+
+94
+00:07:54,010 --> 00:07:57,450
+الحديث خاطئ، العبارة شمالها خاطئة، هذه مرة ثانية.
+
+95
+00:07:57,450 --> 00:08:00,410
+نور عمارة،  اذكري أهمية موازنة الإنتاج.  بِتُساعِدنا في
+
+96
+00:08:00,410 --> 00:08:03,270
+ثلاثة أشياء، وهي .. أول شيء،  تهدف لتخطيط تكلفة
+
+97
+00:08:03,270 --> 00:08:09,540
+الإنتاج. 1.  بقية عمليات الإنتاج ماذا؟ 3. هي
+
+98
+00:08:09,540 --> 00:08:17,140
+حاجة أساسية لموازنات.  ممتاز. شكراً يا أنتِ وقدِكِ يا
+
+99
+00:08:17,140 --> 00:08:22,020
+أحلام،  كيف تتم إعداد موازنات الإنتاج حسب برنامج
+
+100
+00:08:22,020 --> 00:08:26,180
+المشروع؟  يُستخدم لتحقيق أهداف المشروع، ويتم إعدادها
+
+101
+00:08:26,180 --> 00:08:30,240
+بناء على خطوط الإنتاج المختلفة. خطوط الإنتاج، خطوط
+
+102
+00:08:30,240 --> 00:08:33,020
+الخطوط،  الخطوط، خطوط الإنتاج المختلفة بحيث يُحافظ
+
+103
+00:08:33,020 --> 00:08:35,740
+الإنتاج مربوط بتحقيق الكميات المطلوبة من السلع
+
+104
+00:08:39,880 --> 00:08:45,020
+ماشي. ماشي. إلى
+
+105
+00:08:45,020 --> 00:08:54,560
+حرف الغين، شفت الغين؟ بطلع إلى،  ولكن سنتطلع الغين ثم
+
+106
+00:08:54,560 --> 00:09:00,940
+تتفتت. تتفتت.
+
+107
+00:09:00,940 --> 00:09:08,800
+هذه الخطة زمنية، زمنية تتفتت، يعني تقصدين ماشي يا
+
+108
+00:09:08,800 --> 00:09:12,090
+مُسَوّية النظارات؟  لأ. بقى مش شير. بيقولوا معكِ الـ slide
+
+109
+00:09:12,090 --> 00:09:19,670
+بطلّع 18 slide. معكِ الـ slide ماشي، عذراً. نعتذر
+
+110
+00:09:19,670 --> 00:09:24,910
+عن سوء الرؤية. إذا،  أولاً، برامج الإنتاج
+
+111
+00:09:24,910 --> 00:09:28,110
+تخبرني، حسب السلع الموجودة لدينا،  يجب أن نقوم لكل سلعة بخطوة
+
+112
+00:09:28,110 --> 00:09:32,310
+إنتاج،  ونحسب إيراداتها وتكلفتها.  موازنة المبيعات
+
+113
+00:09:32,310 --> 00:09:35,230
+تساعدنا،  والمخزون يساعدنا،  ونبدأ الإنتاج، وبعد
+
+114
+00:09:35,230 --> 00:09:40,180
+ذلك نقسم خطة الإنتاج إلى ماذا؟ إلى الزمن.  نأخذ مثالاً
+
+115
+00:09:40,180 --> 00:09:53,140
+ولا بعد؟  Old Korea. نذكر عيوب موازنة الإنتاج.  موازنة
+
+116
+00:09:53,140 --> 00:09:57,220
+الإنتاج، لو وقع خطأ معين، يصعب معرفة من هو السبب
+
+117
+00:09:57,220 --> 00:10:00,320
+في موازنة الإنتاج، لأنها تكون موازنة شاملة، فيها
+
+118
+00:10:00,320 --> 00:10:05,200
+مشكلة، لو أخطأ أحد، يصعب تحديده.  لو شخصٌ
+
+119
+00:10:05,200 --> 00:10:07,400
+عمل خطأ، من هو؟ نحنُ لا نعلم.
+
+120
+00:10:13,250 --> 00:10:21,850
+هو القانون. خذي بالكِ، سهل. المبيعات بالوحدة زائد مخزون
+
+121
+00:10:21,850 --> 00:10:30,290
+سلعي آخر المدة، ناقص مخزون سلعي أول المدة.  نضع خطاً
+
+122
+00:10:30,290 --> 00:10:35,510
+تحت كلمة وحدة. مبيعات بالوحدة، وخط تحت كلمة سلعي، لأن
+
+123
+00:10:35,510 --> 00:10:41,340
+هناك مخزونات ليست سلعية،  هناك أنواع مخزون أخرى.  نأخذ سؤالاً
+
+124
+00:10:41,340 --> 00:10:46,000
+يالا يا سهام. قولي لنا السؤال. إذا كانت مبيعات إحدى
+
+125
+00:10:46,000 --> 00:10:49,360
+الشركات. .. إذا كانت مبيعات إحدى الشركات الفصلية
+
+126
+00:10:49,360 --> 00:10:53,580
+كالتالي، والمخزون  آخر المدة  من 17% من
+
+127
+00:10:53,580 --> 00:10:58,280
+مبيعات الفصل، ورصيد أول المدة 2001. خذي بالكِ، هذا
+
+128
+00:10:58,280 --> 00:11:02,940
+لازم يأتِ في السؤال، رصيد أول المدة، يجب أن يكون موجوداً
+
+129
+00:11:02,940 --> 00:11:05,880
+معنا وإلا لا نحل السؤال. يكون في الخطأ. عاجباً
+
+130
+00:11:05,880 --> 00:11:10,120
+موازنتكِ.  أنتِ، طبعاً،  على الشريحة هذه لا أستطيع حلّ
+
+131
+00:11:10,120 --> 00:11:14,860
+السؤال.  يجب أن يكون لدي ماذا؟ المبيعات بالوحدة هي
+
+132
+00:11:14,860 --> 00:11:20,140
+خلاص، هي مبيعاتي، أرتب السؤال، وأبدأ الحل.  نحن فقط
+
+133
+00:11:20,140 --> 00:11:23,060
+سنأخذ مبيعاته،  ونرجع مرّة أخرى لراس السؤال، لأنه سنحلّ
+
+134
+00:11:23,060 --> 00:11:26,340
+عن طريقه. إذا،  نبدأ يا أخوات معاً،  نتعلم كيف نصنع
+
+135
+00:11:26,340 --> 00:11:30,240
+موازنة الإنتاج.  موازنة سهلة.  أريد أن أمسح هذا
+
+136
+00:11:39,010 --> 00:11:43,010
+خذي بالكِ، عادةً تأتيكِ الجداول جاهزة،  ولكن أنتِ تملئينها، و
+
+137
+00:11:43,010 --> 00:11:51,190
+تبقين ماشية. موازنة الإنتاج، موازنة
+
+138
+00:11:51,190 --> 00:11:53,730
+الإنتاج بالوحدات هي يا أخوات،  ليست بالدولار.
+
+139
+00:11:53,730 --> 00:12:00,570
+هذه كتكاليف الإنتاج.  حاجة أخرى.  نون (أي الزمن) الذي هو الزمن
+
+140
+00:12:00,570 --> 00:12:05,330
+المبيعات بالوحدة، وخذي بالكِ منها.
+
+141
+00:12:07,940 --> 00:12:14,160
+ليست بالدولار. لو بالدولار،  معناها الحال خاطئ. لو سمح
+
+142
+00:12:14,160 --> 00:12:16,940
+الله، حالتها دولار، معناها جالسة تخترع علم جديد.
+
+143
+00:12:16,940 --> 00:12:25,280
+ما كان القانون يقول؟ آخر
+
+144
+00:12:25,280 --> 00:12:29,200
+المدة؟
+
+145
+00:12:29,200 --> 00:12:33,580
+نطرح
+
+146
+00:12:33,580 --> 00:12:34,780
+الأخير من الأول.
+
+147
+00:12:39,090 --> 00:12:43,210
+نجيبها.  موازنة الإنتاج. إليه الحل. إذا كان
+
+148
+00:12:43,210 --> 00:12:47,570
+العمود هذا الأخير صحيح، كل هذا صحيح. إذا كان خطأ، لا
+
+149
+00:12:47,570 --> 00:12:51,770
+تَحويل، ولا حول ولا قوة إلا بالله.  يالا يا هنادي، أكملي، املأي
+
+150
+00:12:51,770 --> 00:13:00,290
+الجدول.  ما عندكِ؟ واحد، اثنين، ثلاثة، أربعة.
+
+151
+00:13:00,290 --> 00:13:02,570
+شكراً،  ترغبين في إكمال، تفضلي.
+
+152
+00:13:14,340 --> 00:13:19,980
+عشرة آلاف.  شكراً يا هنادي، مخزون
+
+153
+00:13:19,980 --> 00:13:25,400
+سلعي آخر المدة.  نعم.  نسبة المخزون عشرة في
+
+154
+00:13:25,400 --> 00:13:29,000
+المئة،  فنضرب المبيعات في عشرة في المئة، وطبعاً
+
+155
+00:13:29,000 --> 00:13:33,900
+.. طبعاً عشرة في المئة في نفس الشهر،  أم كيف؟ نحنُ
+
+156
+00:13:33,900 --> 00:13:37,620
+انتهينا من النتيجة. السؤال نفسه، اه، في كل فصل عشرة في
+
+157
+00:13:37,620 --> 00:13:46,980
+المبيعات الفصلية، هي 10% من مبيعات الفصل. سأحسبها على
+
+158
+00:13:46,980 --> 00:13:53,760
+طول الخط.
+
+159
+00:13:53,760 --> 00:13:58,680
+يسأل نفسه: من أين أحضرها؟ نضرب
+
+160
+00:13:58,680 --> 00:14:04,680
+المبيعات في 10%. هو السؤال هكذا، السؤال هكذا.
+
+161
+00:14:04,680 --> 00:14:08,500
+الآن يا غدير، نريد مخزون أول المدة.
+
+162
+00:14:12,190 --> 00:14:17,550
+ممتاز يا غدير. أول شهر دائماً معطى في السؤال. طيب، الباقي
+
+163
+00:14:17,550 --> 00:14:24,710
+خذي بالكِ، أخذتيِ  حاجة في المحاسبة، أن مخزون آخر المدة
+
+164
+00:14:24,710 --> 00:14:29,270
+هو أول المدة للفترة القادمة. كمْ سنكتبها؟ ماذا يعني يا
+
+165
+00:14:29,270 --> 00:14:34,530
+سعيد؟  ألف وخمسمائة.
+
+166
+00:14:39,690 --> 00:14:45,350
+واضح، أم أعيده؟  أعيده ثانية؟ كيف سنحصل.. ماشي.
+
+167
+00:14:45,350 --> 00:14:47,190
+دعونا نُكمل، ثم نعيد ثانية.  كيف نحصل على العملية
+
+168
+00:14:47,190 --> 00:14:56,830
+الحسابية؟  زائد ناقص.  زائد ناقص. يالا يا سهام، عشرة آلاف
+
+169
+00:14:56,830
+
+223
+00:20:21,510 --> 00:20:28,510
+كلمة واحدة.. اه..عنا مخزونين.. احنا.. بل
+
+224
+00:20:28,510 --> 00:20:34,270
+اتنين أول المدة خذي بالك.. واحد للإنتاج وواحد
+
+225
+00:20:34,270 --> 00:20:37,370
+لإيش تاني؟ الساعة ماخدناهوش.. مين هيطلع معانا
+
+226
+00:20:37,370 --> 00:20:42,530
+على الجدوى الآن؟ مش طالب.. رقم.. اللي هو الـ 6000
+
+227
+00:20:43,650 --> 00:20:48,010
+إذا ليش 6000 وحدة؟ لأن هذا موازنة الإنتاج؟ كيف أنا
+
+228
+00:20:48,010 --> 00:20:51,690
+عارفة؟ خذي بالك هذه 6000 وحدة والمخزون التاني
+
+229
+00:20:51,690 --> 00:20:55,550
+6720 كل غرام الساعة ماجيبناش الصيرة احنا؟ صيرة
+
+230
+00:20:55,550 --> 00:20:58,630
+الناس هدول ماجيبنهاش، إذا مش هو، خذي بالك، اتفضلي
+
+231
+00:20:58,630 --> 00:21:02,390
+وتسيير الشركة على أساس الاحتفاظ بمخزون سلعي آخر
+
+232
+00:21:02,390 --> 00:21:07,250
+لمدة 25% من المبيعات المخططة للخدرة التالية ومخزون
+
+233
+00:21:07,250 --> 00:21:10,930
+مواد أولية آخر لمدة 40% من إنتاج الخدرة التالية؟
+
+234
+00:21:10,930 --> 00:21:17,120
+هنأخذ الـ 25% ولا الـ 40% يا أحلام؟  15، فضل، إذا كانت
+
+235
+00:21:17,120 --> 00:21:25,420
+مبيعات 2010 قدامي لـ 40% الأول والتاني 4441 و48048
+
+236
+00:21:25,420 --> 00:21:29,960
+مرة واحدة على السواية، فهو موازنة مبيعات من عام
+
+237
+00:21:29,960 --> 00:21:32,900
+2014؟ لأ، عشان في برنامج جديدة، بس هو عادي، يعني
+
+238
+00:21:32,900 --> 00:21:35,120
+الآن احنا بس هنطول موازنة الإنتاج، مالناش علاقة في
+
+239
+00:21:35,120 --> 00:21:42,620
+البلد، أحسب موازنة الإنتاج لنفس الفترة، ميس؟
+
+240
+00:21:43,420 --> 00:21:48,400
+تفضلي، مين كمان حابب يشارك؟ مين كمان يا جماعة؟ يلا
+
+241
+00:21:48,400 --> 00:21:53,560
+يا غادير، تشوفي غادير، كل طالبة تحاول تحل الـ sheet
+
+242
+00:21:53,560 --> 00:21:58,480
+في كشكولها لحد ما تشوف يظبط ولا لأ، القانون أمامك على
+
+243
+00:21:58,480 --> 00:22:01,280
+الصبورة، عفوا، وطبقيه
+
+244
+00:22:11,130 --> 00:22:13,270
+أنتِ بس ممكن.. أيوة، امسحي بس اللي داخل الأقواس
+
+245
+00:22:13,270 --> 00:22:29,210
+لأنه نفسه ممتاز، شكراً يا غادير، هم
+
+246
+00:22:29,210 --> 00:22:35,190
+نفس الشيء أربع فترات.. لأ، خذي بالك هو معطيكي أربع
+
+247
+00:22:35,190 --> 00:22:39,910
+فترات لـ 2009 وفترتين لـ 2010، بتقولي مين كتبوا هم
+
+248
+00:22:39,910 --> 00:22:45,180
+الستة من وين جايه الستة؟ من السؤال، يعني واحد، اتنين،
+
+249
+00:22:45,180 --> 00:22:50,860
+تلاتة، أربعة، واحد، اتنين، مش خمسة، ستة عندنا احنا
+
+250
+00:22:50,860 --> 00:22:57,180
+سنة تانية يا أخوات، أربع لـ 2009، اتنين لـ 2010
+
+251
+00:22:57,180 --> 00:22:59,400
+وعشرة، بدكم تحطوهم واحد، اتنين، تلاتة، أربعة،
+
+252
+00:22:59,400 --> 00:23:02,760
+يعني الربع الأول، الربع الثاني، أنتِ لو كتبتِ ربع
+
+253
+00:23:02,760 --> 00:23:06,720
+الأول أسهل لنا، الربع الأول لعام 2009، الربع الثاني،
+
+254
+00:23:06,720 --> 00:23:08,640
+الربع الثالث، الربع الرابع، هيك أسهل بيكون
+
+255
+00:23:14,720 --> 00:23:20,700
+بعدين الربع الأول 2010، الربع الثاني، يلا
+
+256
+00:23:20,700 --> 00:23:28,620
+يا سماح، أعطيها مبيعات 2009، يعني دائماً
+
+257
+00:23:28,620 --> 00:23:31,220
+يا أخوات، الحل اللي بنبدأه من اليمين خذي بالك مش
+
+258
+00:23:31,220 --> 00:23:37,040
+هتروحي تعملي من الشمال، بيطلع حلك غلط، سؤال تاني يكون خلاص
+
+259
+00:23:37,040 --> 00:23:40,700
+يا غادير؟ يلا يا سماح، تفضلي، 40 ألف
+
+260
+00:23:45,950 --> 00:23:50,210
+60 ألف ما عشان ستة عندنا، اتنين ما عشان إن شاء الله
+
+261
+00:23:50,210 --> 00:23:56,510
+خمسة، 60 ألف، ستة وثلاثين.. ستة وثلاثين ألف، طيب
+
+262
+00:23:56,510 --> 00:24:00,270
+ألفين وعشرة، يعني أنتِ كدهش الأرقام عندك؟ أربعين..
+
+263
+00:24:00,270 --> 00:24:01,930
+أربعين.. أربعين.. أربعين.. أربعين.. أربعين..
+
+264
+00:24:01,930 --> 00:24:02,730
+أربعين.. أربعين.. أربعين.. أربعين.. أربعين..
+
+265
+00:24:02,730 --> 00:24:05,410
+أربعين.. أربعين.. أربعين.. أربعين.. أربعين..
+
+266
+00:24:05,410 --> 00:24:06,030
+أربعين.. أربعين.. أربعين.. أربعين.. أربعين..
+
+267
+00:24:06,030 --> 00:24:06,430
+أربعين.. أربعين.. أربعين.. أربعين.. أربعين..
+
+268
+00:24:06,430 --> 00:24:11,010
+أربعين.. أربعين.. أربعين.. أربعين
+
+269
+00:24:15,300 --> 00:24:22,620
+في السؤال يا عزيزتي، خذي
+
+270
+00:24:22,620 --> 00:24:31,040
+بالك، اقرأي يا سماح، السطر الرقم أربعة لأ
+
+271
+00:24:31,040 --> 00:24:36,220
+اقرئي السؤال، اقرأي السؤال يا عزيزتي، السطر رقم ثلاثة
+
+272
+00:24:36,220 --> 00:24:39,340
+السطر
+
+273
+00:24:39,340 --> 00:24:47,820
+الرقم أربعة، عفواً، لأ، السطر الرابع، أساس الاحتفاظ؟
+
+274
+00:24:47,820 --> 00:25:03,020
+بمخزون سلعي؟ من؟ طيب، كم؟ اقرأي، كم؟ 25%؟
+
+275
+00:25:03,020 --> 00:25:07,480
+للفترة التالية، مش لنفس الشهر زي تاو، سؤال سهل
+
+276
+00:25:07,480 --> 00:25:10,640
+يعني، لو مش واخدة بالك، كله غلط، الله يسهل عليه
+
+277
+00:25:10,640 --> 00:25:13,700
+للفترة التالية
+
+278
+00:25:16,270 --> 00:25:19,130
+وأخر عيد زي ما أنا اتوّى عملت موازنة.. أول حاجة
+
+279
+00:25:19,130 --> 00:25:22,130
+حلّيناها في المحاضرة، هذا موازنة المخزون السلعي كنت
+
+280
+00:25:22,130 --> 00:25:28,110
+مطالعة أسهم أنا زيه، إذا شهر واحد، مخزون آخر مدة
+
+281
+00:25:28,110 --> 00:25:32,610
+واحد هجيبه أو الربع الأول من الربع الثاني، ماشي
+
+282
+00:25:32,610 --> 00:25:38,310
+أقوم أشرح، حطي
+
+283
+00:25:38,310 --> 00:25:42,350
+خط تحت الفترة التالية، أنتم خطّيتم 25% وفرحتم عليها
+
+284
+00:25:42,350 --> 00:25:44,310
+غلط، 40%
+
+285
+00:25:48,720 --> 00:25:51,680
+الـ 40% يعني أنتِ المواد الأولية ما بنرجعش نجيب سيرتها
+
+286
+00:25:51,680 --> 00:25:58,120
+ما وصلناهاش، ارجعوا ثاني السطر الرابع في الفقرة
+
+287
+00:25:58,120 --> 00:26:03,020
+الثانية، على أساس الاحتفاظ بالمخزون السلعي، حطي تحت
+
+288
+00:26:03,020 --> 00:26:07,960
+خط، آخر مدة 25% من المبيعات المخططة لغاية الآن
+
+289
+00:26:07,960 --> 00:26:14,880
+تمام، للفترة التالية، قبل أن أقف هنا، ماشي، زي
+
+290
+00:26:14,880 --> 00:26:19,910
+ما توّي عملناها، أنتِ ليش هنا؟ أنتِ انسحبتِ من الحل؟
+
+291
+00:26:19,910 --> 00:26:24,730
+أيوة، ممتازة
+
+292
+00:26:24,730 --> 00:26:33,650
+نفسي.. ده.. أيوة.. نفسي.. ده.. ده.. ده.. ده
+
+293
+00:26:33,650 --> 00:26:35,590
+..ده.. ده.. ده.. ده.. ده.. ده.. ده.. ده..
+
+294
+00:26:35,590 --> 00:26:39,130
+ده.. ده.. ده.. ده.. ده.. ده.. ده.. ده.. ده
+
+295
+00:26:39,130 --> 00:26:39,490
+..ده.. ده.. ده.. ده.. ده.. ده.. ده.. ده..
+
+296
+00:26:39,490 --> 00:26:40,070
+ده.. ده.. ده.. ده.. ده.. ده.. ده.. ده.. ده
+
+297
+00:26:40,070 --> 00:26:46,250
+..ده.. ده.. ده.. ده.. ده.. ده..
+
+298
+00:26:48,190 --> 00:26:54,390
+وحقوق التأليف، يعني أنا أنا أنا أنا أنا أنا أنا أنا
+
+299
+00:26:54,390 --> 00:26:56,330
+أنا أنا أنا أنا أنا أنا أنا أنا أنا أنا أنا
+
+300
+00:26:56,330 --> 00:26:57,350
+أنا أنا أنا أنا أنا أنا أنا أنا أنا أنا أنا
+
+301
+00:26:57,350 --> 00:26:57,410
+أنا أنا أنا أنا أنا أنا أنا أنا أنا أنا أنا
+
+302
+00:26:57,410 --> 00:26:57,550
+أنا أنا أنا أنا أنا أنا أنا أنا أنا أنا أنا
+
+303
+00:26:57,550 --> 00:27:04,670
+أنا أنا أنا أنا أنا أنا أنا أنا أنا أنا أنا
+
+304
+00:27:04,670 --> 00:27:04,910
+أنا أنا أنا أنا أنا أنا أنا أنا أنا أنا أنا
+
+305
+00:27:04,910 --> 00:27:10,190
+أنا أنا
+
+306
+00:27:16,920 --> 00:27:24,640
+السلوة، 65 في 25%؟ 16 ألف، و25% طبعاً أنتم الحال
+
+307
+00:27:24,640 --> 00:27:28,140
+عندكم أسئلة، لإنه الدفاتر مسطّرة، بتكون الربع
+
+308
+00:27:28,140 --> 00:27:37,040
+الثالث يا سلوة، 36 ألف و25%؟ 93، 44 في 25%؟ 11 ألف
+
+309
+00:27:37,040 --> 00:27:40,540
+11
+
+310
+00:27:40,540 --> 00:27:45,500
+ألف، وأنتِ كيف كتبتِ يا غادية؟ دخل في بعض وبتعلم
+
+311
+00:27:52,280 --> 00:27:57,500
+هو التصحيح بيضيعني على فكرة، هاي الجدول الصف الأول
+
+312
+00:27:57,500 --> 00:28:07,340
+الثاني، عندي إحساس في ناس مش فاهمين حاجة، فعادي
+
+313
+00:28:07,340 --> 00:28:10,460
+فعادي
+
+314
+00:28:10,460 --> 00:28:16,440
+ماشي، 60
+
+315
+00:28:16,440 --> 00:28:17,600
+ألف بـ 25%
+
+316
+00:28:21,000 --> 00:28:29,240
+أيوة؟ مين حابب يجيب لغزته السؤال؟ ممتاز، الله يقطع
+
+317
+00:28:29,240 --> 00:28:32,680
+الأربعين، الأربعين في المئة اللي مش الآن، مواد
+
+318
+00:28:32,680 --> 00:28:36,580
+أولية، احنا في موازنة الإنتاج، خمسة وعشرين في
+
+319
+00:28:36,580 --> 00:28:43,080
+المئة، ارجعي، مين سالها؟ نور ولا مين؟ لأ
+
+320
+00:28:43,080 --> 00:28:47,780
+السؤال المطلوب منه خمس طلبات يا أنتِ، هذا سؤال شامل
+
+321
+00:28:47,780 --> 00:28:51,840
+عشان في امتحان، احنا في الـ band الثاني، الفقرة
+
+322
+00:28:51,840 --> 00:28:59,020
+الثانية، يعني عدّي السطر الرابع، الطالبة اللي سألتها اه
+
+323
+00:28:59,020 --> 00:29:02,360
+يا دلال، في الفقرة الثانية يا أنتِ، عدّي أربعة أسطر
+
+324
+00:29:02,360 --> 00:29:11,420
+شايفة كلمة أساس؟ شوفتيها يا أنتِ؟ أساس إيش؟ أيوة
+
+325
+00:29:11,420 --> 00:29:14,760
+في
+
+326
+00:29:14,760 --> 00:29:20,080
+المئة، الفترة التالية، يعني واحد من واحد هتجبها، هتجبها
+
+327
+00:29:20,080 --> 00:29:24,080
+من اثنين، طب اثنين من واحد، هتجيبها من ثلاثة، طب ثلاثة
+
+328
+00:29:24,080 --> 00:29:27,680
+من أربعة، واحدة من أربعة، واضح؟ عشان هيك عملنا هيك،
+
+329
+00:29:27,680 --> 00:29:33,400
+شكراً يا دلال على السؤال، مخزون أول المدة، خلوني
+
+330
+00:29:33,400 --> 00:29:36,740
+أطلع بقى، هتكون ستة آلاف، حاجة ثانية، اه، كيف عرفنا
+
+331
+00:29:36,740 --> 00:29:39,400
+إن هي ستة آلاف؟ خذي بقى من كلمة واحدة، ستة آلاف
+
+332
+00:29:39,400 --> 00:29:39,740
+واحدة
+
+333
+00:29:43,530 --> 00:29:51,270
+bubble bag، أيوة، دي أسهل حاجة، 15 ألف، بعدين 16، أقصد
+
+334
+00:29:51,270 --> 00:30:00,470
+و52، بعدين 9 ألف، مين
+
+335
+00:30:00,470 --> 00:30:04,790
+يا أخوات، يعطينا العملية الحسابية اللي بنسويها؟
+
+336
+00:30:04,790 --> 00:30:08,910
+آية؟ يعني بنحكي 40 ألف، ده الـ 15 ألف ناقص 6 ألف
+
+337
+00:30:08,910 --> 00:30:15,710
+بيدينا 49 ألف، 49 كيف هيك؟ عشان كله أحمر، عيدي ثاني
+
+338
+00:30:15,710 --> 00:30:19,950
+آية، أربعة آلاف، أربعين ألف، أربعين ألف زائد ثلاثة عشر
+
+339
+00:30:19,950 --> 00:30:22,950
+ألف ناقص ستة ستة ستة ستة ستة ستة ستة ستة ستة ستة
+
+340
+00:30:22,950 --> 00:30:23,310
+ستة ستة ستة ستة ستة ستة ستة ستة ستة ستة ستة
+
+341
+00:30:23,310 --> 00:30:25,130
+ستة ستة ستة ستة ستة ستة ستة ستة ستة ستة ستة
+
+342
+00:30:25,130 --> 00:30:25,930
+ستة ستة ستة ستة ستة ستة ستة ستة ستة ستة ستة
+
+343
+00:30:25,930 --> 00:30:36,170
+ستة ستة ستة ستة ستة ستة ستة ستة ستة ستة ستة
+
+344
+00:30:36,170 --> 00:30:39,370
+ستة
+
+345
+00:30:40,770 --> 00:30:49,070
+60 ألف زائد 16152 ناقص 15 ألف، واحد وستون ألف واثنين
+
+346
+00:30:49,070 --> 00:30:54,550
+وخمسين، عزيمة يلا
+
+347
+00:30:54,550 --> 00:31:05,990
+يا إسرائيل، زعلون، الربع الثالث كيف
+
+348
+00:31:05,990 --> 00:31:11,590
+يا إسرائيل، زعلون، حسبنا الربع الثالث؟ ممتازة
+
+349
+00:31:11,590 --> 00:31:17,310
+..ممتازة، شكراً يا عزيزتي أحلام، الربع الرابع؟ إيش
+
+350
+00:31:17,310 --> 00:31:20,610
+هنسوي؟
+
+351
+00:31:20,610 --> 00:31:30,290
+ممتازة يا أحلام، قداش ما بتعطينا؟ بس؟
+
+352
+00:31:30,290 --> 00:31:32,170
+يلا يا هديل، الصف، الربع الأول؟
+
+353
+00:31:47,600 --> 00:31:51,940
+بنوقف لإنه مافيش عندنا الربع الثالث، بنوقف عنده،
+
+354
+00:31:51,940 --> 00:31:57,220
+ماشي؟ لإنه فيه بيانات ناقصة، اللي هي الربع الثالث
+
+355
+00:31:57,220 --> 00:32:01,740
+لـ 2010، مش معطى في السؤال، نعم؟
+
+356
+00:32:03,290 --> 00:32:08,490
+لأ، لازم ناخذ منه حل، الربع الأول، طلع عليه، هتلاقي
+
+357
+00:32:08,490 --> 00:32:17,710
+أخذنا منه الربع الأول، أعيدها ثاني، سهلة ولا صعبة؟
+
+358
+00:32:17,710 --> 00:32:26,290
+كمان
+
+359
+00:32:26,290 --> 00:32:27,370
+سؤال عن إنتاج؟
+
+360
+00:32:30,020 --> 00:32:33,620
+بس هذا الـ bundle بتاعك صح؟ نعم، سؤال الـ bundle
+
+361
+00:32:33,620 --> 00:32:42,580
+بتاعك؟ اه، نعم، السطر الثالث، سبتمبر، 57400، والسطر
+
+362
+00:32:42,580 --> 00:32:45,340
+الثالث، خاطر كنتوا اللي قعدتوا تقولولي لدقة، مش أنا
+
+363
+00:32:45,340 --> 00:32:49,900
+لأ، صح يا عزيزتي، صح، صح، أنا اتلخبطت معاكم، صح، أنا اتلخبطت
+
+364
+00:32:49,900 --> 00:32:53,440
+معاكم، واضح، طب راجعوا ولا وصلتوا؟ راجعوا
+
+365
+00:32:58,100 --> 00:33:02,320
+راجعوا يا أخوات، تشوفوا أين الخلل، بس هو جمع، بعدين
+
+366
+00:33:02,320 --> 00:33:09,420
+طلع وليس العكس، صح؟
+
+367
+00:33:09,420 --> 00:33:15,040
+لا تجمعوا الأمور على ضلالة، مش معقول يعني آلتك الحاسبة
+
+368
+00:33:15,040 --> 00:33:22,220
+إلاّ ده كانت ضالة هذه الآلة، نكتب
+
+369
+00:33:22,220 --> 00:33:23,240
+السؤال ثانيةً
+
+370
+00:33:32,270 --> 00:33:37,430
+إذا بلغت موازنة
+
+371
+00:33:37,430 --> 00:33:40,830
+المبيعات
+
+372
+00:33:40,830 --> 00:33:43,910
+للثلاثة
+
+373
+00:33:43,910 --> 00:33:54,250
+أشهر الأولى لإحدى المصانع كانت ثمانية ألفين
+
+374
+00:33:54,250 --> 00:33:59,670
+دولار، جانب اليمين، ولا الديكيايس؟ لأ، هذا سؤال جاي
+
+375
+00:33:59,670 --> 00:34:10,860
+فقط، ألفين دولار، 3000 دولار، 1500 دولار، وعلمتِ أن سعر
+
+376
+00:34:10,860 --> 00:34:17,240
+البيع لهذا المنتج هو
+
+377
+00:34:17,240 --> 00:34:23,040
+10 دولار، إذا
+
+378
+00:34:23,040 --> 00:34:25,900
+كان مخزون سلعي أول المدة
+
+379
+00:34:32,450 --> 00:34:37,210
+عشرين وحدة، ومخزون
+
+380
+00:34:37,210 --> 00:34:41,790
+سلعي آخر المدة عشرة
+
+381
+00:34:41,790 --> 00:34:46,170
+في المئة من
+
+382
+00:34:46,170 --> 00:34:54,610
+المبيعات المخططة، عشرة عشرة عشرة عشرة
+
+383
+00:34:54,610 --> 00:34:59,930
+عشرة عشرة، من المبيعات المخططة للفترة التالية
+
+384
+00:35:02,790 --> 00:35:09,630
+المطلوب، أعدي موازنة الإنتاج، ما طلعتيش اليوم؟ لأ لأ
+
+385
+00:35:09,630 --> 00:35:15,930
+لأ، الله، معقول ما طلعتوش؟ حاضر، كل طالبة معها
+
+386
+00:35:15,930 --> 00:35:20,230
+دقيقتين، ترسم الجدول وتطلع الفكرة، يلا يا جماعة
+
+387
+00:35:20,230 --> 00:35:25,770
+بنشوف كيف يعني، ممكن أبعث لكِ سيارة، ياريت كل
+
+388
+00:35:25,770 --> 00:35:27,210
+طالبتين يحلّوا سوى
+
+389
+00:35:32,640 --> 00:35:38,120
+ما يا أنتِ، عندكِ خمس مطلوبات في السؤال، مش لسؤال
+
+390
+00:35:38,120 --> 00:35:47,660
+واحد، يعني كل طالبتين يحلّوا مع بعض، حل جماعي، هنادي
+
+391
+00:35:47,660 --> 
\ No newline at end of file
diff --git a/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/VTOTmfV6dfU_postprocess.srt b/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/VTOTmfV6dfU_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..4f2c43a1d3a9633af8788c25d283924def03bb46
--- /dev/null
+++ b/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/VTOTmfV6dfU_postprocess.srt
@@ -0,0 +1,1744 @@
+1
+00:00:20,890 --> 00:00:23,070
+عوضوا بالله السميع العليم من الشيطان الرجيم .. بسم
+
+2
+00:00:23,070 --> 00:00:25,690
+الله الرحمن الرحيم .. الحمد لله والصلاة والسلام
+
+3
+00:00:25,690 --> 00:00:29,470
+على مصطفى الأمين سيدنا محمد وعلى أهله ومن ساره
+
+4
+00:00:29,470 --> 00:00:32,970
+عزوجل سامده .. في بداية السلام عليكم ورحمة الله ..
+
+5
+00:00:32,970 --> 00:00:38,210
+كيف حالكم؟ كيف أصبحتوا اليوم؟ كويسي إن شاء الله؟ما
+
+6
+00:00:38,210 --> 00:00:42,330
+زلنا في الموازنات التشغيلية تعرفنا مع بعض
+
+7
+00:00:42,330 --> 00:00:45,930
+المحاضرات السابقة عنها اللي هي موازنة المبيعات و
+
+8
+00:00:45,930 --> 00:00:48,770
+أخدنا .. أخدناها بالتفصيل و كيف هي تم إعدادها و
+
+9
+00:00:48,770 --> 00:00:51,510
+الفرق بين المبيعات بالوحدة و المبيعات بالدولار بعد
+
+10
+00:00:51,510 --> 00:00:55,510
+هيك طرقنا إلى موضوع موازنة المخزون إذا انتوقفنا
+
+11
+00:00:55,510 --> 00:00:58,490
+حسب الجدول الهدى عند موازنة ياشي على المخزون
+
+12
+00:00:58,490 --> 00:01:01,130
+السلعي حكينا المخازن إلها عدة أنواع في عندنا مخزون
+
+13
+00:01:01,130 --> 00:01:07,570
+سلعي و مخزون مواد نصف مصنعة و مخزون مواد ..تم
+
+14
+00:01:07,570 --> 00:01:12,190
+تصنيعه الموال اللي تم تصنيعه هي المخزون السلع
+
+15
+00:01:12,190 --> 00:01:14,810
+ياخدوا بالك فيه هيجينا قدام كمان مخزون ان شاء الله
+
+16
+00:01:14,810 --> 00:01:21,770
+خلونا احنا مع اول مخزون كان عندنا سؤال اتوقع كان
+
+17
+00:01:21,770 --> 00:01:24,890
+عندنا سؤال شركة تشجر
+
+18
+00:01:32,910 --> 00:01:37,090
+شركة الفجر سياساتها في المخزون السلعي لاتقل عن 25%
+
+19
+00:01:37,090 --> 00:01:42,030
+من مبيعات الشهر التالي ماشي أعدي موازنة المخزون
+
+20
+00:01:42,030 --> 00:01:44,010
+السلعي طبعا موازنة المخزون السلعي من أسهل
+
+21
+00:01:44,010 --> 00:01:49,590
+الموازنات من أسهلها موازنة
+
+22
+00:01:49,590 --> 00:02:00,510
+المخزون السلعي شكل هذا يا أخوات نون المبيعات
+
+23
+00:02:00,510 --> 00:02:02,070
+خدي بالك بالوحدة
+
+24
+00:02:09,800 --> 00:02:16,260
+نسبة المخزون موازنة
+
+25
+00:02:16,260 --> 00:02:21,840
+ميمسي المخزون السلعي موازنة المخزون السلعي وعطينا
+
+26
+00:02:21,840 --> 00:02:27,580
+احنا noon اللي هي الزمن واحد شهر يناير فبراير مارس
+
+27
+00:02:27,580 --> 00:02:33,160
+تيل اربع اش .. اربع عشر كتبناه اعطينا المبيعات يا
+
+28
+00:02:33,160 --> 00:02:38,200
+سلوى في السؤال معاكي ماشي اه يا غدير
+
+29
+00:02:45,800 --> 00:02:48,160
+جداش الناس بقى؟ حبسة واحدة و عشر دقيقة
+
+30
+00:03:05,350 --> 00:03:08,130
+بحكينا سياسة المخزون السليعي دا تقريعا 25% من
+
+31
+00:03:08,130 --> 00:03:12,050
+مبيعات الشهر التالي مين الشهر اللي بيجي بعد شهر
+
+32
+00:03:12,050 --> 00:03:15,730
+واحد يا هانادي شاصي؟ شهر اتنين شهر اتنين خودي بالك
+
+33
+00:03:15,730 --> 00:03:19,970
+مين
+
+34
+00:03:19,970 --> 00:03:26,610
+الشهر اللي بيجي بعد شهر اتنين يا عيال عوضي؟ تلاتة
+
+35
+00:03:26,610 --> 00:03:33,460
+مين الشهر اللي بيجي بعد شهر تلاتة؟ اربع يا مريمطب
+
+36
+00:03:33,460 --> 00:03:36,960
+على الهدفش ليش؟ لأنه في الشهر خمسة ألف .. ربع ال
+
+37
+00:03:36,960 --> 00:03:40,560
+.. ألفين .. ألفين في خمسة و عشرين في المية ألف و
+
+38
+00:03:40,560 --> 00:03:43,700
+خمس سنة .. ألف و خمس سنة .. ألف و خمس سنة ستةلاف
+
+39
+00:03:43,700 --> 00:03:48,600
+في خمسة و عشرين في المية ألف
+
+40
+00:03:48,600 --> 00:03:49,680
+و متين و خمسين .. ألف و متين و خمسين .. ألف و متين
+
+41
+00:03:49,680 --> 00:03:49,760
+و خمسين .. ألف و متين و خمسين .. ألف و متين و
+
+42
+00:03:49,760 --> 00:03:52,000
+خمسين .. ألف و متين و خمسين .. ألف و متين و خمسين
+
+43
+00:03:52,000 --> 00:03:56,740
+.. ألف و متين و خمسين .. ألف و متين و خمسين .. ألف
+
+44
+00:03:56,740 --> 00:04:01,760
+و متين و خمسين .. ألف و متين و خمسين .. ألف و متين
+
+45
+00:04:01,760 --> 00:04:07,750
+و خمأربعة تلات في خمسة و عشرين أنا بقول مش باخد
+
+46
+00:04:07,750 --> 00:04:11,750
+بالي من الرقم خد بالك هذه السياسة بتتغير مش قاعدة
+
+47
+00:04:11,750 --> 00:04:15,530
+يعني ممكن يقول خمسة و عشرين في الميه من نفس الشهر
+
+48
+00:04:15,530 --> 00:04:19,390
+خلاص من نفس الشهر واحد واحد اتنين اتنين ممكن يقول
+
+49
+00:04:19,390 --> 00:04:29,270
+الشهر التالي ممكن يقول بعد شهرين حسب السؤال أعيدها
+
+50
+00:04:29,270 --> 00:04:34,210
+تاني؟ سهلة؟إذا إيش قال السؤال؟ أعدي موازنة المقصود
+
+51
+00:04:34,210 --> 00:04:39,310
+السلعي بحيطه لا تقل عن 25% مبيعات الشهر التالت
+
+52
+00:04:39,310 --> 00:04:44,010
+إحنا الآن في الشهر التلاتة الشهر القادم هيكون شهر
+
+53
+00:04:44,010 --> 00:04:48,350
+أربع بنجيب مبيعاته و بنضربها في 25% زي ما إحنا
+
+54
+00:04:48,350 --> 00:04:53,670
+عاملين على الصبر أعيدها؟
+
+55
+00:04:53,670 --> 00:04:55,070
+أعيدها تاني؟
+
+56
+00:05:10,360 --> 00:05:19,460
+مون اسمها دي؟ الآن يا أخوات موازنة
+
+57
+00:05:19,460 --> 00:05:23,740
+الإنتاج، بس لا أعرفش إيش لإنما مش طالع موازنة
+
+58
+00:05:23,740 --> 00:05:30,340
+الإنتاج، زهر معاكوا أه؟ زهر معاكم في ال slide هيه؟
+
+59
+00:05:30,340 --> 00:05:34,940
+اللي هي
+
+60
+00:05:34,940 --> 00:05:37,860
+موازنة الإنتاج، يا عزيزي طيب اللي عاملة، فضل الله
+
+61
+00:05:37,860 --> 00:05:43,660
+سمحتيمافيش بيبقى .. مافيش بيبقى وضبطه ماشي احنا
+
+62
+00:05:43,660 --> 00:05:46,760
+الآن في موازنة الإنتاج اللي جاية بعد معادة المخزون
+
+63
+00:05:46,760 --> 00:05:51,500
+السلعي قدكم يا هميه موازنة الإنتاج، فضلا سأله
+
+64
+00:05:51,500 --> 00:05:58,620
+يسمع؟
+
+65
+00:05:58,620 --> 00:06:04,300
+يعني ينوى؟ أول حاجة بيساعدنا موازنة الإنتاج على
+
+66
+00:06:04,300 --> 00:06:09,680
+تخطيط تكليف الإنتاج، جدش هيكلفنا الإنتاج نين؟2.
+
+67
+00:06:09,820 --> 00:06:12,920
+تستخدم هذه المواد لتوقيت عمليات الإنتاج من مختلف
+
+68
+00:06:12,920 --> 00:06:16,360
+السلاح أي أنها تعتبر أساسي لبناء وإعداد موازنات
+
+69
+00:06:16,360 --> 00:06:21,100
+مختلفة ومختلفة عناصر تكليف الإنتاج رقم 2 مش بس في
+
+70
+00:06:21,100 --> 00:06:23,820
+أنه موازنة الإنتاج بالساعدني في تخطيط تكليف
+
+71
+00:06:23,820 --> 00:06:28,960
+الإنتاج كمان بالساعد في تخطيط توقيت الإنتاج ممكنش
+
+72
+00:06:28,960 --> 00:06:33,960
+هتننتج رقم 3 هي حاجة للأساس لموازنات عدة حاجة
+
+73
+00:06:33,960 --> 00:06:36,400
+للأساس معناها بقدرش أجيب الموازنات اللي بعدك اللي
+
+74
+00:06:36,400 --> 00:06:39,860
+هي تكون موجودة زي المبيعات زي إيش؟موازنة أولية
+
+75
+00:06:39,860 --> 00:06:42,220
+..موازنة الأعمال والتكاليف الإنتاجية الأولية
+
+76
+00:06:42,220 --> 00:06:42,260
+..موازنة الأعمال والتكاليف الإنتاجية الأولية
+
+77
+00:06:42,260 --> 00:06:44,120
+..موازنة الأعمال والتكاليف الإنتاجية الأولية
+
+78
+00:06:44,120 --> 00:06:45,100
+..موازنة الأعمال والتكاليف الإنتاجية الأولية
+
+79
+00:06:45,100 --> 00:06:46,780
+..موازنة الأعمال والتكاليف الإنتاجية الأولية
+
+80
+00:06:46,780 --> 00:06:50,200
+..موازنة الأعمال والتكاليف الإنتاجية الأولية
+
+81
+00:06:50,200 --> 00:06:54,720
+..موازنة الأعمال والتكاليف الإنتاجية الأولية
+
+82
+00:06:54,720 --> 00:06:58,940
+..موازنة
+
+83
+00:06:58,940 --> 00:07:01,640
+الأعمال والتكاليف الإنتاجية الأولية ..موازنة
+
+84
+00:07:01,640 --> 00:07:04,080
+الأعمال والتكاليف الإنتاجية الأولية ..موازنة
+
+85
+00:07:10,560 --> 00:07:17,840
+تعتبر موازنة الإنتاج هي
+
+86
+00:07:17,840 --> 00:07:25,920
+حاجة الأساس لموازنات عدة كموازنة
+
+87
+00:07:25,920 --> 00:07:31,280
+المواد الأولية والمخزون السلعي وراح ساكت، دلال
+
+88
+00:07:31,280 --> 00:07:34,700
+كموازن الشيء الاصطناعي؟ المواد الأولية والمخزون
+
+89
+00:07:34,700 --> 00:07:39,590
+السلعي السلعي؟تخطيف موازنة الإنتاج، يا عزيزي، هذا
+
+90
+00:07:39,590 --> 00:07:43,850
+أساس غلط كان مواضن الأولية وقجول عمال والتكلفة
+
+91
+00:07:43,850 --> 00:07:46,750
+الإنتاجية .. شو كان؟ أمامك على الصبورة موازنة
+
+92
+00:07:46,750 --> 00:07:49,670
+المخزون السلعي معتمدة على المبيعات مش على الإنتاج
+
+93
+00:07:49,670 --> 00:07:54,010
+الأرقام المكتوبة أمامنا مبيعات أتجا بالإنتاج، ده
+
+94
+00:07:54,010 --> 00:07:57,450
+العبارة خاطرة، العبارة شمالها خاطرة، ده مرة تانية
+
+95
+00:07:57,450 --> 00:08:00,410
+نور عمارة أذكر أهمية موازنة الإنتاج، بس ساعدنا في
+
+96
+00:08:00,410 --> 00:08:03,270
+تالت شغلات، اللي هي .. أول شي تهديت تخطيف تكلف
+
+97
+00:08:03,270 --> 00:08:09,540
+الإنتاج .. واحدبقيت عمليات الانتاج مين؟ تلاتة هي
+
+98
+00:08:09,540 --> 00:08:17,140
+حاجة الأساس لموازنات ممتاز شكرا يا انت قدكوا يا
+
+99
+00:08:17,140 --> 00:08:22,020
+أحلام كيفية إعداد موازنات الانتاج حسب برنامج
+
+100
+00:08:22,020 --> 00:08:26,180
+المشروع مستخدم لتحقيق أهداف المشروع ويتم إعدادها
+
+101
+00:08:26,180 --> 00:08:30,240
+بناء على خطوط الانتاج المختلفة خطوط الانتاج خطوط
+
+102
+00:08:30,240 --> 00:08:33,020
+الخطوط الخطوط الخطوط الانتاج المختلفة بحيث يحفظ
+
+103
+00:08:33,020 --> 00:08:35,740
+انتاج مربوط تحقيق ممكن السلع من السلع
+
+104
+00:08:39,880 --> 00:08:45,020
+ماشى ماشى إلى
+
+105
+00:08:45,020 --> 00:08:54,560
+حرف الغن شفت غن بطلع إلى بس هنطلع غن ثم
+
+106
+00:08:54,560 --> 00:09:00,940
+تفتت تفتت
+
+107
+00:09:00,940 --> 00:09:08,800
+هذه الخطة زمانية زمانية تفتت يعني تقصد ماشى يا
+
+108
+00:09:08,800 --> 00:09:12,090
+مسوي النضارةلأ بقى مش شير بيقولوا معاكش ال slide
+
+109
+00:09:12,090 --> 00:09:19,670
+بطلّع 18 slide معاكش ال slide ماشي عنتي ماشي نعتذر
+
+110
+00:09:19,670 --> 00:09:24,910
+عن سوق الرؤية إذا أنا أول حاجة برامج الإنتاج
+
+111
+00:09:24,910 --> 00:09:28,110
+بيحكيلي حسب سلع اللي عندنا لازم نعمل لكل سلعة خطوة
+
+112
+00:09:28,110 --> 00:09:32,310
+إنتاج و نحسب إيرادتها و تكليفها موازنة النبيعات
+
+113
+00:09:32,310 --> 00:09:35,230
+بتساقية و المخزون بيساعدونا و نصيروا إنتاج و بعد
+
+114
+00:09:35,230 --> 00:09:40,180
+هيك بنقسم خطة الإنتاج إلى أيش إلى الزمنناخد مثال
+
+115
+00:09:40,180 --> 00:09:53,140
+ولا لسه؟ Old Korea نسمى عيوب موازنة الإنتاج موازنة
+
+116
+00:09:53,140 --> 00:09:57,220
+الإنتاج لو وقع خطأ معين صعب نعرف مين هو السبب
+
+117
+00:09:57,220 --> 00:10:00,320
+لموازنة الإنتاج لأنها بتكون موازنة شاملة فيها
+
+118
+00:10:00,320 --> 00:10:05,200
+مشكلة لو اتكب أحدهم خطأ من الصعب تحديده لو واحد
+
+119
+00:10:05,200 --> 00:10:07,400
+عمل عملة، مين هو؟ احنا مش حلجين
+
+120
+00:10:13,250 --> 00:10:21,850
+هي القانون خدي بالك سهل المبيعات بالوحدة زاد مخزون
+
+121
+00:10:21,850 --> 00:10:30,290
+سلعي أخر المدة ناقص مخزون سلعي أول المدة بنحط خط
+
+122
+00:10:30,290 --> 00:10:35,510
+تحت كلمة وحدة مبيعات بالوحدة وخط تحت كلمة سلعي لإن
+
+123
+00:10:35,510 --> 00:10:41,340
+في مخزونات مش سلعي في أنواع مخزون آخرناخد سؤال
+
+124
+00:10:41,340 --> 00:10:46,000
+يالا يا سمهان قايلنا السؤال إذا كانت مبيعات إحدى
+
+125
+00:10:46,000 --> 00:10:49,360
+الشركات .. إذا كانت مبيعات إحدى الشركات الفصلية
+
+126
+00:10:49,360 --> 00:10:53,580
+كالقناتي والمفصول مفصول أخر مدة من الـ 17% من
+
+127
+00:10:53,580 --> 00:10:58,280
+مبيعات الفصل ورصيد أول المدة 2001 .. خودي بالك هذه
+
+128
+00:10:58,280 --> 00:11:02,940
+لازم تيجي في السؤال رصيد أول المدة لازم يكون موجود
+
+129
+00:11:02,940 --> 00:11:05,880
+معانا وإلا مانحلش السؤال يكون في الخطأ عاجب
+
+130
+00:11:05,880 --> 00:11:10,120
+موازنتك أنتطبعاً هيك على الشريحة هذه بقدرش أحل
+
+131
+00:11:10,120 --> 00:11:14,860
+السؤال لازم يكون عندي مين؟ المبيعات بالوحدة هي
+
+132
+00:11:14,860 --> 00:11:20,140
+خلاص هي مبيعاتي برتب السؤال و ببدأ أحل احنا بس
+
+133
+00:11:20,140 --> 00:11:23,060
+هناخد مبيعاته و نرجع مرتان لراس السؤال لإنه هنحل
+
+134
+00:11:23,060 --> 00:11:26,340
+عن طريقه إذا نبدأ يا أخوات مع بعض نتعلم كيف نسوي
+
+135
+00:11:26,340 --> 00:11:30,240
+موازنات لإنتاج واحد موازنة سهلة بدي أمسح هذا
+
+136
+00:11:39,010 --> 00:11:43,010
+خُد يبالك عادة بيجيك الجداول جاهزة بس أنت تعبيها و
+
+137
+00:11:43,010 --> 00:11:51,190
+تبقى ماشية موازنة الإنتاج موازنة
+
+138
+00:11:51,190 --> 00:11:53,730
+الإنتاج بالوحدات هي أخوات عملا ما بتكون بالدولار
+
+139
+00:11:53,730 --> 00:12:00,570
+هذه كتكاليف الإنتاج حاجة تانية نون اللي هو الزمن
+
+140
+00:12:00,570 --> 00:12:05,330
+المبيعات بالوحدة و خُد يبالك منها
+
+141
+00:12:07,940 --> 00:12:14,160
+مش بالدولار لو بالدولار معناها الحال غلط لو لو سمح
+
+142
+00:12:14,160 --> 00:12:16,940
+الله حالتها الدولار معناها جاعدة بتخترع علم جديد
+
+143
+00:12:16,940 --> 00:12:25,280
+ايش القانون كان يقول؟ آخر
+
+144
+00:12:25,280 --> 00:12:29,200
+المدة؟
+
+145
+00:12:29,200 --> 00:12:33,580
+بنقدم
+
+146
+00:12:33,580 --> 00:12:34,780
+الآخر على الأول
+
+147
+00:12:39,090 --> 00:12:43,210
+بنجيبها الموازنة، الإنتاج، إليه الحل إذا كان
+
+148
+00:12:43,210 --> 00:12:47,570
+العمود هذا الأخر صحيح، كل هذا صح إذا كان غلط، لا
+
+149
+00:12:47,570 --> 00:12:51,770
+حول ولا قوة الله بالله يلا يا هناد انجازي، انعب
+
+150
+00:12:51,770 --> 00:13:00,290
+الجدول إيش نون عندك؟ واحد، اتنين، تلاتة، أربع
+
+151
+00:13:00,290 --> 00:13:02,570
+شكرا، حابة تكملي، تفضلي
+
+152
+00:13:14,340 --> 00:13:19,980
+عشرة ألف شكرا يا هانادي مخزون
+
+153
+00:13:19,980 --> 00:13:25,400
+سلعي آخر المدة ولا أهلله نسبة المخزون عشرة في
+
+154
+00:13:25,400 --> 00:13:29,000
+المية فمضرب المبيعات الواحدة عشرة في المية وطبعا
+
+155
+00:13:29,000 --> 00:13:33,900
+.. طبعا عشرة في المية في نفس الشهر ولا كيف؟ احنا
+
+156
+00:13:33,900 --> 00:13:37,620
+خلصنا من النتجة للسؤال نفسه اه في كل فصل عشرة في
+
+157
+00:13:37,620 --> 00:13:46,980
+المبيعات الفصلاه هي 10% من مبيعات الفصل هحسبها على
+
+158
+00:13:46,980 --> 00:13:53,760
+طول حد
+
+159
+00:13:53,760 --> 00:13:58,680
+بيسأل نفسه من وين جابوها أضغط
+
+160
+00:13:58,680 --> 00:14:04,680
+المبيعات الواحدة في 10% هو السؤال هيك، السؤال هيك
+
+161
+00:14:04,680 --> 00:14:08,500
+الآن يا غدير بدنا مخزون أول المدة
+
+162
+00:14:12,190 --> 00:14:17,550
+ممتاز يا غدير أول شهر دايما معطف السؤال طب الباقي
+
+163
+00:14:17,550 --> 00:14:24,710
+خدي بالك أخدتي حاجة في المحاسبة أنه مخزون أخر مدة
+
+164
+00:14:24,710 --> 00:14:29,270
+هو أول مدة للفترة القادمة قداش هنكتبها يعني ايه يا
+
+165
+00:14:29,270 --> 00:14:34,530
+سعيد؟ هال .. ألف و خمس سنية
+
+166
+00:14:39,690 --> 00:14:45,350
+واضح ولا أعيدها؟ أعيدها تاني؟ كيف هنجيب ..ماشي
+
+167
+00:14:45,350 --> 00:14:47,190
+خلنا نخلص وبعدين نعيد تاني كيف هنجيب العمل
+
+168
+00:14:47,190 --> 00:14:56,830
+الحسابية؟ زائد نقص زائد نقص يلا يا سمهن عشرة ألف
+
+169
+00:14:56,830 --> 00:15:01,910
+زاد ألف عشرة
+
+170
+00:15:01,910 --> 00:15:07,550
+ألف زاد ألف ايه انت؟ عشرة ألف ناقص ألفين تسعة ألف
+
+171
+00:15:07,550 --> 00:15:14,210
+ممتاز شكرا تسعة ألفوحدة تسعة ألف اش وحدة اسرق
+
+172
+00:15:14,210 --> 00:15:28,690
+الزعلون خمستاشر الف زاد الف و خمسمية ستاشر
+
+173
+00:15:28,690 --> 00:15:34,450
+الف و خمسمية ناقص الف شكرا
+
+174
+00:15:34,450 --> 00:15:44,090
+يعني اسرق اسرق دبون12000 زي الـ1213400 نقص 1511700
+
+175
+00:15:44,090 --> 00:15:53,890
+شكرا آخر حاجة البندي الظابط تفضلي ماليان 18400
+
+176
+00:15:53,890 --> 00:16:05,410
+16000 16400 16700 طيب نقص 1200 16400 16400 شكرا لأ
+
+177
+00:16:05,410 --> 00:16:15,000
+16400 عيد تانيكيف يتم إعداد موازنة الإنتاج؟ كل
+
+178
+00:16:15,000 --> 00:16:17,100
+المعطيات من السؤال اللي إحنا بسرتبنا الجدول، هذا
+
+179
+00:16:17,100 --> 00:16:21,180
+كله عملناه أول حاجة، نون الفترة الزمنية، أربع فصول
+
+180
+00:16:21,180 --> 00:16:25,000
+كتبناهم المبيعات بالوحدة، عملتها باللون الأحمر
+
+181
+00:16:25,000 --> 00:16:28,720
+لأنه عندنا مبيعات بالدولار لازم تكون بالوحدة،
+
+182
+00:16:28,720 --> 00:16:32,840
+كتبناها كل شهر مبيعات وحسب السؤال القانون بيقول
+
+183
+00:16:32,840 --> 00:16:36,620
+مبيعات بالوحدة زائد المخزون أخر مدة ناقص مخزون أول
+
+184
+00:16:36,620 --> 00:16:41,350
+مدةهيكون السؤال مابعطيك معطلات لحتى تجيبهم بيحكي
+
+185
+00:16:41,350 --> 00:16:46,150
+إن مخزون أخر المدة 10% من المبيعات قولنا إذا 10000
+
+186
+00:16:46,150 --> 00:16:51,010
+في 10% .. 15000 في 10% .. 12000 في 10% .. 16000 في
+
+187
+00:16:51,010 --> 00:16:54,990
+10% .. إيش؟ في المية و بعدين العمود رقم 4 مخزون
+
+188
+00:16:54,990 --> 00:16:58,870
+أول المدة في قاعدة أخدتها في المحاسبة مخزون أخر
+
+189
+00:16:58,870 --> 00:17:02,730
+المدة هو مخزون أول مدة للفترة القادمة إذا واحد
+
+190
+00:17:02,730 --> 00:17:07,620
+بيصير ل 2 و 2 ل 3 و 3 ل 4طب واحد مالوش من شهر
+
+191
+00:17:07,620 --> 00:17:10,740
+اتناش هو معطينيها بيكون لألفين جيبناها من شهر
+
+192
+00:17:10,740 --> 00:17:15,100
+اتناش طب كيف اللي أنا الحمر هدول؟ عشر ألف زاد
+
+193
+00:17:15,100 --> 00:17:18,180
+احداش ناقص ألفين خمستاشر ألف زاد ألف و خمسمية ناقص
+
+194
+00:17:18,180 --> 00:17:26,920
+ألف و هكذا أعيدها تاني؟ أعيدها؟ لازم يعطيك السعر
+
+195
+00:17:26,920 --> 00:17:30,420
+بتروح بتقسم المبيعات على السعر بتجيب المبيعات
+
+196
+00:17:30,420 --> 00:17:35,830
+بالوحدة ماشي شكرا على السؤالإذا أزمنتكوا سؤالات
+
+197
+00:17:35,830 --> 00:17:40,410
+سؤال لو أعطانا المبيعات بالدولار بيكون عندك معلومة
+
+198
+00:17:40,410 --> 00:17:43,970
+زيادة في السؤال اللي هي المبيعات اللي هي السعر
+
+199
+00:17:43,970 --> 00:17:47,090
+عفوا لو قسمنا المبيعات بالدولار على السعر بنجيب
+
+200
+00:17:47,090 --> 00:17:51,510
+الكمية المبيعات
+
+201
+00:17:51,510 --> 00:17:56,050
+بالدولار اللي هي الإيراد تقسيم السعر بجيب المبيعات
+
+202
+00:17:56,050 --> 00:17:57,550
+بالوحدة sheet
+
+203
+00:18:03,860 --> 00:18:09,780
+سؤال أول sheet
+
+204
+00:18:09,780 --> 00:18:15,480
+سؤال أول بدنا
+
+205
+00:18:15,480 --> 00:18:21,100
+نقل السؤال يقيا سامون مع بعض لحتى نجيب موازنة
+
+206
+00:18:21,100 --> 00:18:23,120
+الإنتاج هو طالب كسب موازنة النبيعات مش بيقول
+
+207
+00:18:23,120 --> 00:18:26,120
+لحالكوا اللي أنا على الطول ع موازنة الإنتاج يلّا
+
+208
+00:18:26,120 --> 00:18:26,700
+يقيا سامون
+
+209
+00:18:39,320 --> 00:18:50,820
+سعر البيع 2.5 طيب أربع
+
+210
+00:18:50,820 --> 00:18:58,020
+سنوية كل جداش يعني ممتاز كل ثلاث شهور كل ثلاث شهور
+
+211
+00:18:58,020 --> 00:19:05,290
+هتكون مبيعاتها كانت يتفضليبنحط خط تحت كلمة وحدة
+
+212
+00:19:05,290 --> 00:19:10,210
+هدول
+
+213
+00:19:10,210 --> 00:19:14,790
+أكم رقم إيه جوا كتبوا؟ أربع، السنة أكم تلت شهور
+
+214
+00:19:14,790 --> 00:19:20,990
+فيها؟ أربع، السنة أكم تلت شهور فيها؟ أربع، عشانك
+
+215
+00:19:20,990 --> 00:19:27,650
+أعطاكي أربعأيوة لإن السؤال من البداية حكى تخطط
+
+216
+00:19:27,650 --> 00:19:33,390
+لتكون مربع سنوية أكم تالت شهور في السنة؟ أربع ماشي
+
+217
+00:19:33,390 --> 00:19:42,370
+أربع في تلاتة هي اتناشر شهر فضلي هل
+
+218
+00:19:42,370 --> 00:19:46,830
+احنا جبنا سيرة المادة الأولية؟لأ، لغاية الأقل، لأ،
+
+219
+00:19:46,830 --> 00:19:57,870
+خلّيكم معايا لو سمحتوا، لأ، تفضلي لغاية
+
+220
+00:19:57,870 --> 00:20:07,030
+الأقل، الكلام هذا احنا أول مرة نشوفه، طيب شوي
+
+221
+00:20:07,030 --> 00:20:14,290
+شوي، مخزون أول مدة الصلاعي، حط تحته خط، 6000 وحدة
+
+222
+00:20:16,270 --> 00:20:21,510
+ايوة قاية؟ كاملة .. كاملة .. بعد كلمة واحدة .. بعد
+
+223
+00:20:21,510 --> 00:20:28,510
+كلمة واحدة .. اه .. عنا مخزونين .. احنا .. بل
+
+224
+00:20:28,510 --> 00:20:34,270
+اتنين أول المدة خودي بالك .. واحد للإنتاج و واحد
+
+225
+00:20:34,270 --> 00:20:37,370
+لإيش تاني .. الساعة ماخدناهوش .. مين هيطلع معانا
+
+226
+00:20:37,370 --> 00:20:42,530
+على الجدوى الآن؟ مش طالب .. رقم .. اللي هو ال 6000
+
+227
+00:20:43,650 --> 00:20:48,010
+إذا ليش 6000 وحدة لأن هذا موازنة الإنتاج؟ كيف أنا
+
+228
+00:20:48,010 --> 00:20:51,690
+عارفة تخودي بالك هذه 6000 وحدة والمخزون التاني
+
+229
+00:20:51,690 --> 00:20:55,550
+6720 كل غرام الساعة ماجيبناش الصيرة احنا؟ صيرة
+
+230
+00:20:55,550 --> 00:20:58,630
+الناس هدول ماجيبنهاش، إذا مش هو، خودي بالك، اتفضلي
+
+231
+00:20:58,630 --> 00:21:02,390
+وتسيير الشركة على أساس الاحتفاظ بمخزون سلعي أخر
+
+232
+00:21:02,390 --> 00:21:07,250
+لمدة 25% من مياعات مخططة الخدرة التالية ومخزون
+
+233
+00:21:07,250 --> 00:21:10,930
+مواد أولية أخر لمدة 40% من إنتاج الخدرة التالية؟
+
+234
+00:21:10,930 --> 00:21:17,120
+هناخد الـ25 و لا الـ40 يا أحلام15، فضل فإذا كانت
+
+235
+00:21:17,120 --> 00:21:25,420
+مبيعات 2010 قدامي لـ 40 الأول والتاني 4441 و48048
+
+236
+00:21:25,420 --> 00:21:29,960
+مرة واحدة على السواية، فهو موازن مبيعات من عام
+
+237
+00:21:29,960 --> 00:21:32,900
+2014؟ لأ، عشان في برنامج جديدة، بس هو عادي، يعني
+
+238
+00:21:32,900 --> 00:21:35,120
+الآن احنا بس هنطول موازنة الإنتاج، مالناش علاقة في
+
+239
+00:21:35,120 --> 00:21:42,620
+البلد أحسب موازنة الإنتاج لنفس الفترة ميس؟
+
+240
+00:21:43,420 --> 00:21:48,400
+تفضل مين كمان حابب يشارك؟ مين كمان يا جماعة؟ يلا
+
+241
+00:21:48,400 --> 00:21:53,560
+يا غادير، تشوف غادير كل طالبة تحاول تحل ال sheet
+
+242
+00:21:53,560 --> 00:21:58,480
+في كشكولها لحد تشوف يظبط ولا لأ القانون أمامك ع
+
+243
+00:21:58,480 --> 00:22:01,280
+الصبورة عفوا وطبقه
+
+244
+00:22:11,130 --> 00:22:13,270
+أنتي بس ممكن .. أيوة تمسحي بس اللي داخل الأعمل
+
+245
+00:22:13,270 --> 00:22:29,210
+لإنه نفسه ممتاز شكرا يا غادير هم
+
+246
+00:22:29,210 --> 00:22:35,190
+نفس الاش أربع قطرات .. لأ خد بالك هو معطيكي أربع
+
+247
+00:22:35,190 --> 00:22:39,910
+فترات ل 2009 و فترتين ل 2010 بتقول مين كتبوا هم
+
+248
+00:22:39,910 --> 00:22:45,180
+الستةمن وين جوا ستة؟ من السؤال، يعني واحد، اتنين،
+
+249
+00:22:45,180 --> 00:22:50,860
+تلاتة، أربعة، واحد، اتنين، مش خمسة، ستة عندنا احنا
+
+250
+00:22:50,860 --> 00:22:57,180
+سنة تانية يا أخوات أربع لألفين وتسعة تنتين لألفين
+
+251
+00:22:57,180 --> 00:22:59,400
+وعشرة، بدكوا تحطيهم واحد، اتنين، تلاتة، أربعة،
+
+252
+00:22:59,400 --> 00:23:02,760
+يعني الربع الأول، الربع التاني، انت لو كتبت ربع
+
+253
+00:23:02,760 --> 00:23:06,720
+الأول أسهل لنا، الربع الأول لعام 2009، ربع التاني،
+
+254
+00:23:06,720 --> 00:23:08,640
+ربع التالت، ربع الرابع، هيك أسهل بيكون
+
+255
+00:23:14,720 --> 00:23:20,700
+بعدين الضبع الأول 2010 الضبع التاني يلا
+
+256
+00:23:20,700 --> 00:23:28,620
+يا سماح أعطيها مبيعات 2009 يعني دائما
+
+257
+00:23:28,620 --> 00:23:31,220
+يا أخوات الحل اللي بنبدأه من اليمين خدي بالك مش
+
+258
+00:23:31,220 --> 00:23:37,040
+هتروح عملة من الشمال بيطلع حلك سؤال تاني يكون خلاص
+
+259
+00:23:37,040 --> 00:23:40,700
+يا غدير؟ يلا يا سماح تفضلي 40 ألف
+
+260
+00:23:45,950 --> 00:23:50,210
+ستين ألف ماعشان ستة عندنا تنتين ماعشان ان شاء الله
+
+261
+00:23:50,210 --> 00:23:56,510
+خمس ستين ألف ستة و تلاتين .. ستة و تلاتين ألف طيب
+
+262
+00:23:56,510 --> 00:24:00,270
+ألفين و عشرة يعني أنت كدهش الأقام عندك؟ أربعين ..
+
+263
+00:24:00,270 --> 00:24:01,930
+أربعين .. أربعين .. أربعين .. أربعين .. أربعين ..
+
+264
+00:24:01,930 --> 00:24:02,730
+أربعين .. أربعين .. أربعين .. أربعين .. أربعين ..
+
+265
+00:24:02,730 --> 00:24:05,410
+أربعين .. أربعين .. أربعين .. أربعين .. أربعين ..
+
+266
+00:24:05,410 --> 00:24:06,030
+أربعين .. أربعين .. أربعين .. أربعين .. أربعين ..
+
+267
+00:24:06,030 --> 00:24:06,430
+أربعين .. أربعين .. أربعين .. أربعين .. أربعين ..
+
+268
+00:24:06,430 --> 00:24:11,010
+أربعين .. أربعين .. أربعين .. أربعين
+
+269
+00:24:15,300 --> 00:24:22,620
+في السؤال يا عزيزي خدي
+
+270
+00:24:22,620 --> 00:24:31,040
+بالك اقرأ يا سماح السطر الرقم أربع لأ
+
+271
+00:24:31,040 --> 00:24:36,220
+اقرأ السؤال اقرأ السؤال يا عزيزي السطر الرقم تلاتة
+
+272
+00:24:36,220 --> 00:24:39,340
+السطر
+
+273
+00:24:39,340 --> 00:24:47,820
+الرقم أربع عفوا لأ السطر الرابعأساس الاحتفاظ؟
+
+274
+00:24:47,820 --> 00:25:03,020
+بمخزون سلعي؟ من؟ طيب، كم لقراك؟ كم لقراك؟ 25%؟
+
+275
+00:25:03,020 --> 00:25:07,480
+للفترة التالية، مش لنفس الشهر زي تاو، سؤال سهل
+
+276
+00:25:07,480 --> 00:25:10,640
+يعني، لو مش ماخدة بالك كله غلط، الله يسهل عليه
+
+277
+00:25:10,640 --> 00:25:13,700
+للفترة التالية
+
+278
+00:25:16,270 --> 00:25:19,130
+وأخر عيدة زى ما أنا اتوى عملت موازنة .. أول حاجة
+
+279
+00:25:19,130 --> 00:25:22,130
+حلناها في المحاضرة هاد موازنة المخزون السلعي كنت
+
+280
+00:25:22,130 --> 00:25:28,110
+مطالعة أسهم أنا زيه إذا شهر واحد مخزون أخر مدمن
+
+281
+00:25:28,110 --> 00:25:32,610
+واحد هجيبه أو الضبع الأول من الضبع التاني ماشي
+
+282
+00:25:32,610 --> 00:25:38,310
+أقوم أشرح حط
+
+283
+00:25:38,310 --> 00:25:42,350
+خط تحت الفترة التالية أنتوا خطوا 25% وفرحتوا عليها
+
+284
+00:25:42,350 --> 00:25:44,310
+غلط 140%
+
+285
+00:25:48,720 --> 00:25:51,680
+الـ 40% يعني أنت المواد الأولية مابناش نجيب السيرة
+
+286
+00:25:51,680 --> 00:25:58,120
+ماوصلناهاش ارجعوا تاني السطر الرابع في الفقرة
+
+287
+00:25:58,120 --> 00:26:03,020
+التانية على أساس الاحتفاظ بالمقصود السريعي حطه تحت
+
+288
+00:26:03,020 --> 00:26:07,960
+خط أخر مدة 25% من المنبعات المخاطرة لغاية الآن
+
+289
+00:26:07,960 --> 00:26:14,880
+تمام للفترة التالية قبل أن أقف هان ماشي زي
+
+290
+00:26:14,880 --> 00:26:19,910
+ما توي عملناهاانت ليش هنا انت انسحبتي من الحل؟
+
+291
+00:26:19,910 --> 00:26:24,730
+ايوة ممتازة
+
+292
+00:26:24,730 --> 00:26:33,650
+نفسي .. ده .. ايوة .. نفسي .. ده .. ده .. ده .. ده
+
+293
+00:26:33,650 --> 00:26:35,590
+.. ده .. ده .. ده .. ده .. ده .. ده .. ده .. ده ..
+
+294
+00:26:35,590 --> 00:26:39,130
+ده .. ده .. ده .. ده .. ده .. ده .. ده .. ده .. ده
+
+295
+00:26:39,130 --> 00:26:39,490
+.. ده .. ده .. ده .. ده .. ده .. ده .. ده .. ده ..
+
+296
+00:26:39,490 --> 00:26:40,070
+ده .. ده .. ده .. ده .. ده .. ده .. ده .. ده .. ده
+
+297
+00:26:40,070 --> 00:26:46,250
+.. ده .. ده .. ده .. ده .. ده .. ده ..
+
+298
+00:26:48,190 --> 00:26:54,390
+وحقوق التأليف يعني انا انا انا انا انا انا انا انا
+
+299
+00:26:54,390 --> 00:26:56,330
+انا انا انا انا انا انا انا انا انا انا انا انا
+
+300
+00:26:56,330 --> 00:26:57,350
+انا انا انا انا انا انا انا انا انا انا انا انا
+
+301
+00:26:57,350 --> 00:26:57,410
+انا انا انا انا انا انا انا انا انا انا انا انا
+
+302
+00:26:57,410 --> 00:26:57,550
+انا انا انا انا انا انا انا انا انا انا انا انا
+
+303
+00:26:57,550 --> 00:27:04,670
+انا انا انا انا انا انا انا انا انا انا انا انا
+
+304
+00:27:04,670 --> 00:27:04,910
+انا انا انا انا انا انا انا انا انا انا انا انا
+
+305
+00:27:04,910 --> 00:27:10,190
+انا انا
+
+306
+00:27:16,920 --> 00:27:24,640
+السلوة 65 في 25%؟ 16 ألف و 25% طبعاً انتوا الحال
+
+307
+00:27:24,640 --> 00:27:28,140
+عندكوا أسئلة لإنه الدفاتر مسطرة بتكون الرابع
+
+308
+00:27:28,140 --> 00:27:37,040
+التالت يا سلوة 36 ألف و 25%؟ 93 44 في 25%؟ 11 ألف
+
+309
+00:27:37,040 --> 00:27:40,540
+11
+
+310
+00:27:40,540 --> 00:27:45,500
+ألف و أنت كيف كتب يا غدية؟ دخل في بعض و بتعلم
+
+311
+00:27:52,280 --> 00:27:57,500
+هو التصيير بضيحنى على فكرة هاي الجدول الصف الأول
+
+312
+00:27:57,500 --> 00:28:07,340
+التانى عندى إحساس فى ناس مش فاهمين حاجة فعادي
+
+313
+00:28:07,340 --> 00:28:10,460
+فعادي
+
+314
+00:28:10,460 --> 00:28:16,440
+ماشى 60
+
+315
+00:28:16,440 --> 00:28:17,600
+ألف ب 25
+
+316
+00:28:21,000 --> 00:28:29,240
+أيوة؟ مين حاب يجيب لزمنته السؤال؟ ممتاز، الله يقطع
+
+317
+00:28:29,240 --> 00:28:32,680
+الأربعين، الأربعين في الميه اللي مش الآن، مواد
+
+318
+00:28:32,680 --> 00:28:36,580
+أولية، احنا في موازنة الإنتاج، خمسة وعشرين في
+
+319
+00:28:36,580 --> 00:28:43,080
+الميه، ارجعيا، مين سأليه، نور ولا مين؟ لأ
+
+320
+00:28:43,080 --> 00:28:47,780
+السؤال المطلوب منه خمس طلبات يا انتيهذا سؤال شامل
+
+321
+00:28:47,780 --> 00:28:51,840
+عشان في امتحان احنا في ال band التاني الفقرة
+
+322
+00:28:51,840 --> 00:28:59,020
+التانى يعنى عدى السطر الرابع الطالب اللى سألته اه
+
+323
+00:28:59,020 --> 00:29:02,360
+يا دلال فى الفقرة التانى يا أنتى عدى أربع أسطول
+
+324
+00:29:02,360 --> 00:29:11,420
+شايفة كلمة أساس؟ شوفتيها يا أنتى؟ أساس ايش؟ ايوة
+
+325
+00:29:11,420 --> 00:29:14,760
+فى
+
+326
+00:29:14,760 --> 00:29:20,080
+الميةالفترة التالية، يعني واحد من وان حاجبه، حاجبه
+
+327
+00:29:20,080 --> 00:29:24,080
+من اتنين، طب اتنين من وان حاجبه من تلاتة، طب تلاتة
+
+328
+00:29:24,080 --> 00:29:27,680
+من أربع، واحدة من أربع، واضح؟ عشان هيك عملنا هيك،
+
+329
+00:29:27,680 --> 00:29:33,400
+شكرا يا دلال على السؤال، مخزون أول المدة، خلوني
+
+330
+00:29:33,400 --> 00:29:36,740
+أطلع بقى، هتكون ست آلاف حاجة تانية، أه، كيف عرفنا
+
+331
+00:29:36,740 --> 00:29:39,400
+إن هي ست آلاف؟ خودي بقى من كلمة واحدة، ست آلاف
+
+332
+00:29:39,400 --> 00:29:39,740
+واحدة
+
+333
+00:29:43,530 --> 00:29:51,270
+bubble bag ايوة دي أسهل حاجة 15 ألف بعدين 16 أقصد
+
+334
+00:29:51,270 --> 00:30:00,470
+و 52 بعدين 9 ألف مين
+
+335
+00:30:00,470 --> 00:30:04,790
+يا أخوات يعطينا العملية الحسابية اللي بنسويها؟
+
+336
+00:30:04,790 --> 00:30:08,910
+آية؟ يعني بنحكي 40 ألف ده ال 15 ألف ناقص 6 ألف
+
+337
+00:30:08,910 --> 00:30:15,710
+بيدينا 49 ألف 49 كيف هيك؟عشان كله أحمر عيدي تاني
+
+338
+00:30:15,710 --> 00:30:19,950
+آية أربع تلاف أربعين ألف أربعين ألف زائد تلستاشر
+
+339
+00:30:19,950 --> 00:30:22,950
+ألف ناقص ستة ستة ستة ستة ستة ستة ستة ستة ستة ستة
+
+340
+00:30:22,950 --> 00:30:23,310
+ستة ستة ستة ستة ستة ستة ستة ستة ستة ستة ستة ستة
+
+341
+00:30:23,310 --> 00:30:25,130
+ستة ستة ستة ستة ستة ستة ستة ستة ستة ستة ستة ستة
+
+342
+00:30:25,130 --> 00:30:25,930
+ستة ستة ستة ستة ستة ستة ستة ستة ستة ستة ستة ستة
+
+343
+00:30:25,930 --> 00:30:36,170
+ستة ستة ستة ستة ستة ستة ستة ستة ستة ستة ستة ستة
+
+344
+00:30:36,170 --> 00:30:39,370
+ست
+
+345
+00:30:40,770 --> 00:30:49,070
+60 ألف زاد 16152 ناقص 15 ألف واحد وستين ألف ومتان
+
+346
+00:30:49,070 --> 00:30:54,550
+وخمسين عزيمة يالا
+
+347
+00:30:54,550 --> 00:31:05,990
+يا إسرائيل زعلون الربع التالت كيف
+
+348
+00:31:05,990 --> 00:31:11,590
+يا إسرائيل زعلون حسبنا الربع التالت؟ممتازة
+
+349
+00:31:11,590 --> 00:31:17,310
+..ممتازة شكرا يا عزيزي أحلام الضبع الرابع؟ اش
+
+350
+00:31:17,310 --> 00:31:20,610
+هنسوي؟
+
+351
+00:31:20,610 --> 00:31:30,290
+ممتازة يا أحلام، قداش مابعطينا؟ بس؟
+
+352
+00:31:30,290 --> 00:31:32,170
+يلا يا هديل الصفد الضبع الأول؟
+
+353
+00:31:47,600 --> 00:31:51,940
+بنوقف لأنه مافيش عندنا قبع التالت، بنوقف عنده،
+
+354
+00:31:51,940 --> 00:31:57,220
+ماشي؟ لأنه فيه بعنوماته ناقصة، اللي هي قبع التالت
+
+355
+00:31:57,220 --> 00:32:01,740
+لـ 2010، مش معبرة في السؤال نعم؟
+
+356
+00:32:03,290 --> 00:32:08,490
+لأ لازم أخدنا منه حل ضبع الأول طلع عليه هتلاقي
+
+357
+00:32:08,490 --> 00:32:17,710
+أخدنا منه ضبع الأول أعيدها تاني سهلة ولا صعبة؟
+
+358
+00:32:17,710 --> 00:32:26,290
+كمان
+
+359
+00:32:26,290 --> 00:32:27,370
+سؤال عن إنتاج؟
+
+360
+00:32:30,020 --> 00:32:33,620
+بس هذا ال bundle بتاعك صح؟ نعم سؤال ال bundle
+
+361
+00:32:33,620 --> 00:32:42,580
+بتاعك؟ اه نعم السطر بتالت سبتمبر 57400 و السطر
+
+362
+00:32:42,580 --> 00:32:45,340
+التالت خاطر كنتوا اللي قعدوا تقوليني لدقان مش انا
+
+363
+00:32:45,340 --> 00:32:49,900
+لأ صح يا عزيزي صح صح انا اتلقى معاكم صح انا اتلقى
+
+364
+00:32:49,900 --> 00:32:53,440
+معاكم واضح طب راجوا ولا وصلتوا؟ راجوا
+
+365
+00:32:58,100 --> 00:33:02,320
+راجعوا يا أخوات لتشوفوا أين الخلل بس هو جمع بعدين
+
+366
+00:33:02,320 --> 00:33:09,420
+طلع و ليس العكس صح؟
+
+367
+00:33:09,420 --> 00:33:15,040
+لا تجتمع الأم على ضلالة مش معقول يعني آلتك الحاسبة
+
+368
+00:33:15,040 --> 00:33:22,220
+إلا ده كانت ضالة هذه الآلة نكتب
+
+369
+00:33:22,220 --> 00:33:23,240
+السؤال التالف
+
+370
+00:33:32,270 --> 00:33:37,430
+إذا بلغت موازنة
+
+371
+00:33:37,430 --> 00:33:40,830
+النبيعات
+
+372
+00:33:40,830 --> 00:33:43,910
+للتلت
+
+373
+00:33:43,910 --> 00:33:54,250
+أشهر الأولى لإحدى المصانع كانت تالي ألفين
+
+374
+00:33:54,250 --> 00:33:59,670
+دولار جانب اليمينس ولا الديكيايس؟ لأ هذا سؤال جاي
+
+375
+00:33:59,670 --> 00:34:10,860
+فقط ألفين دولار3000 دولار 1500 دولار وعلمتي أن سعر
+
+376
+00:34:10,860 --> 00:34:17,240
+البيع لهذا المنتج هو
+
+377
+00:34:17,240 --> 00:34:23,040
+10 دولار إذا
+
+378
+00:34:23,040 --> 00:34:25,900
+كان مخزون صلاعي أول المدة
+
+379
+00:34:32,450 --> 00:34:37,210
+عشرين واحدة ومخزون
+
+380
+00:34:37,210 --> 00:34:41,790
+سلعي آخر المدة عشرة
+
+381
+00:34:41,790 --> 00:34:46,170
+في المية من
+
+382
+00:34:46,170 --> 00:34:54,610
+المبيعات المخططة عشر عشرة عشرة عشرة
+
+383
+00:34:54,610 --> 00:34:59,930
+عشرة عشرة من المبيعات المخططة للفترة التالية
+
+384
+00:35:02,790 --> 00:35:09,630
+المطلوب أعدي موازنة الإنتاج ما طلعتيش اليوم؟ لأ لأ
+
+385
+00:35:09,630 --> 00:35:15,930
+لالله، معقول ما طلعتوش؟ حاضر، كل طالبة معاه
+
+386
+00:35:15,930 --> 00:35:20,230
+دقيقتين ترسم الجدول و تطلع الفكرة، يلا يا جماعة
+
+387
+00:35:20,230 --> 00:35:25,770
+بنشوف كيف يعني، ممكن ابعتلك سيارة، ياريت كل
+
+388
+00:35:25,770 --> 00:35:27,210
+طالبتين يحلوا سوا
+
+389
+00:35:32,640 --> 00:35:38,120
+ما يا أنتي عندك خمس مطلوبات في السؤال مش لسؤال
+
+390
+00:35:38,120 --> 00:35:47,660
+واحد يعني كل طالبتين يحلوا مع بعض حل الجماعي هنادي
+
+391
+00:35:47,660 --> 00:35:52,920
+نجيبلك صديقة إيمان
+
+392
+00:35:52,920 --> 00:35:58,420
+تعالي و أجي جانب النادي دينا
+
+393
+00:35:58,420 --> 00:36:00,560
+و أجي جانب الطالب اللي قدامك
+
+394
+00:36:03,530 --> 00:36:10,070
+جنب راز؟ بسمة العشي تعالوا جنب الطالب اللي أنا مش
+
+395
+00:36:10,070 --> 00:36:13,910
+شايفاها كل طالبتين يحلوا سواء، ما تحلوش لوحدك
+
+396
+00:36:13,910 --> 00:36:20,590
+اسلام مع مين بتحل جاعة؟ نعم؟ ماشي، إذا كانوا
+
+397
+00:36:20,590 --> 00:36:26,890
+تلاتة، يحلوا تلاتة سواء السؤال
+
+398
+00:36:26,890 --> 00:36:29,370
+في إيه؟ خدوا بالكم، تنطلقوش في الحال
+
+399
+00:36:58,580 --> 00:36:59,820
+أنتي و ال band اللي معاكي؟
+
+400
+00:37:08,550 --> 00:37:13,590
+مين يا جماعة عنده مشكلة في السؤال؟ لازم الأرقام
+
+401
+00:37:13,590 --> 00:37:19,990
+تكون منطقية مش عارفت تاكر فيه؟ افصاش اعطانيها عيد
+
+402
+00:37:19,990 --> 00:37:29,850
+السؤال تاني قرأ السؤال تاني يا دلال ممتاز
+
+403
+00:37:40,000 --> 00:37:50,860
+ممتازة يعني مين
+
+404
+00:37:50,860 --> 00:37:54,760
+يطلع يحل سؤال على الصابورة؟ في وجوه جديدة، مين
+
+405
+00:37:54,760 --> 00:37:59,040
+كمان؟ مين يا أخوات قاعد ماشية؟ تفضل يا ولاد، و لأ
+
+406
+00:37:59,040 --> 00:38:04,240
+معقول؟ روح أقعد ورا الجاية إن شاء الله، بكون
+
+407
+00:38:04,240 --> 00:38:16,860
+الموضوع أسهل بكتيرحاضر يا ردي من
+
+408
+00:38:16,860 --> 00:38:20,480
+وين جيبها شهر تلاتة؟ شهر تلاتة .. اول .. اول تلاتة
+
+409
+00:38:20,480 --> 00:38:23,520
+شهور .. تلاتة شهور؟ اه طيب .. طيب؟
+
+410
+00:38:34,310 --> 00:38:39,950
+عشرة في المية من مبيعات مخطرة الفترة التالية ماشي؟
+
+411
+00:38:39,950 --> 00:38:48,430
+مش لازم هنا يكون أربع عشان نجيب هذي احنا؟ نفعش
+
+412
+00:38:48,430 --> 00:38:53,170
+و أنا تستعجل بالحل لإنه خلاص يعني Zero Zero، بدي
+
+413
+00:38:53,170 --> 00:38:58,770
+أظبط القيامة في الظاهرة أيوة؟
+
+414
+00:39:10,270 --> 00:39:18,930
+تقرأ السؤال كاملا، تقرأ السؤال كاملا وبتركيز ممتاز
+
+415
+00:39:28,730 --> 00:39:39,550
+خلصتي؟ صح ده ده انا احنا عاملنا ده ده امتاز
+
+416
+00:39:39,550 --> 00:39:44,030
+ليش مش هنحل على 2200 لإنه ال 2000 دولار؟ دولار
+
+417
+00:39:44,030 --> 00:39:47,270
+لإننا حاولنا تحويلها لنا واضح يا أسمها؟ ليش السعر؟
+
+418
+00:39:47,270 --> 00:39:52,110
+مخزون أخر مدة؟ مخزون أخر مدة أنه 10% من المبيعات
+
+419
+00:39:52,110 --> 00:39:57,950
+اللي مخططة للفكرة التالية يعني حيكون 300 في 10%
+
+420
+00:39:58,760 --> 00:40:07,540
+أيوة واضح
+
+421
+00:40:07,540 --> 00:40:12,720
+يا غديط عشان
+
+422
+00:40:12,720 --> 00:40:17,550
+ال two بتستعجلعشان أول المدة 20 سنة و اتنين سنة و
+
+423
+00:40:17,550 --> 00:40:18,930
+أتنين سنة و أتنين سنة و أتنين سنة و أتنين سنة و
+
+424
+00:40:18,930 --> 00:40:23,810
+أتنين سنة و أتنين سنة و أتنين سنة و أتنين سنة و
+
+425
+00:40:23,810 --> 00:40:26,230
+أتنين سنة و أتنين سنة و أتنين سنة و أتنين سنة و
+
+426
+00:40:26,230 --> 00:40:27,550
+أتنين سنة و أتنين سنة و أتنين سنة و أتنين سنة و
+
+427
+00:40:27,550 --> 00:40:29,850
+أتنين سنة و أتنين سنة و أتنين سنة و أتنين سنة و
+
+428
+00:40:29,850 --> 00:40:33,510
+أتنين سنة و أتنين سنة و أتنين سنة و أتنين سنة و
+
+429
+00:40:33,510 --> 00:40:35,590
+أتنين سنة و أتنين
+
+430
+00:40:50,060 --> 00:40:57,580
+هذه؟ ات نزلها مابضه مش هينحل، ماشي مش هينحل الغياب
+
+431
+00:40:57,580 --> 00:41:01,600
+هذه واضح
+
+432
+00:41:01,600 --> 00:41:10,930
+ولا لسه صعب؟عيدوا تاني؟ اي سؤال او استفسار؟ مرة
+
+433
+00:41:10,930 --> 00:41:17,510
+تانية السبت التوقيت هيكون صيفي السبت القادر يعني
+
+434
+00:41:17,510 --> 00:41:21,710
+بيكونوا زي هيك بدئين من خلاص المحاضرة التانية ماشي
+
+435
+00:41:21,710 --> 00:41:27,670
+تيجوا بدر شوية بدر بساعة ان شاء الله اي سؤال؟
+
+436
+00:41:27,670 --> 00:41:29,330
+يعطيكوا العافية
+
diff --git a/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/ViY1kLGYsyU_raw.json b/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/ViY1kLGYsyU_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..22dd399cc2c01e1713c0df1eef0a23572e4f27dd
--- /dev/null
+++ b/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/ViY1kLGYsyU_raw.json
@@ -0,0 +1 @@
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"text": "والتكاليف كانت 100 للأربع مراحل لو صار عندنا المرحلة الخامسة هصيروا 135 خد بالك خد بالك هذه تراكمية مش عشان ده سوى الخمسة بتدلغ الرابعة لأ المصنع كله بده يصير يعمل السلع لأن التكاليف جدش صارت يعني هذي حسبها لحاله هذي أنا حسبتها لأن لو احنا مشينا للمرحلة الخامسة هصير تكاليفنا 135", "tokens": [2407, 6027, 2655, 4117, 6027, 33911, 25961, 2655, 2319, 24976, 10721, 25513, 3615, 3714, 23557, 5016, 1211, 45164, 20328, 9640, 43242, 8315, 9673, 2288, 5016, 37977, 33962, 10943, 3794, 3660, 8032, 9381, 13546, 14407, 42652, 16490, 3215, 20666, 4117, 16490, 3215, 20666, 4117, 29538, 6055, 23557, 24793, 10632, 37893, 6225, 8592, 7649, 11778, 3224, 8608, 2407, 7578, 33962, 2304, 3794, 3660, 39894, 3215, 1211, 17082, 34892, 16758, 27884, 5296, 10721, 9673, 9381, 1863, 3615, 28242, 3224, 47525, 3224, 7251, 9381, 13546, 7251, 25957, 1211, 21136, 1211, 3615, 5296, 33456, 16712, 4117, 6027, 33911, 10874, 3215, 8592, 20328, 9640, 2655, 37495, 22653, 8032, 8848, 1829, 11331, 35457, 11296, 5296, 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1826.22, "word": " اليوم", "probability": 0.7274169921875}, {"start": 1826.22, "end": 1826.32, "word": " مش", "probability": 0.87744140625}, {"start": 1826.32, "end": 1826.64, "word": " هتجل", "probability": 0.986572265625}, {"start": 1826.64, "end": 1826.88, "word": " مرة", "probability": 0.969970703125}, {"start": 1826.88, "end": 1827.2, "word": " واحدة", "probability": 0.95654296875}, {"start": 1827.2, "end": 1827.6, "word": " يعني", "probability": 0.817138671875}, {"start": 1827.6, "end": 1829.64, "word": " بعرف", "probability": 0.6884765625}, {"start": 1829.64, "end": 1830.16, "word": " ضايق", "probability": 0.7176106770833334}, {"start": 1830.16, "end": 1830.46, "word": " العشر", "probability": 0.49462890625}, {"start": 1830.46, "end": 1831.0, "word": " دقايق", "probability": 0.806640625}, {"start": 1831.0, "end": 1832.4, "word": " قرار", "probability": 0.94189453125}, {"start": 1832.4, "end": 1832.9, "word": " التخلص", "probability": 0.994873046875}, {"start": 1832.9, "end": 1833.02, "word": " من", "probability": 0.98876953125}, {"start": 1833.02, "end": 1833.28, "word": " البضاعة", "probability": 0.9210205078125}, {"start": 1833.28, "end": 1834.04, "word": " متقادمة", "probability": 0.83056640625}, {"start": 1834.04, "end": 1835.1, "word": " و", "probability": 0.93701171875}, {"start": 1835.1, "end": 1835.46, "word": " معانا", "probability": 0.8733723958333334}, {"start": 1835.46, "end": 1835.62, "word": " ال", "probability": 0.468505859375}, {"start": 1835.62, "end": 1835.76, "word": " sheet", "probability": 0.8076171875}, {"start": 1835.76, "end": 1836.0, "word": " يا", "probability": 0.955078125}, {"start": 1836.0, "end": 1836.26, "word": " جماعة", "probability": 0.9856770833333334}, {"start": 1836.26, "end": 1836.46, "word": " ضال", "probability": 0.775146484375}, {"start": 1836.46, "end": 1836.68, "word": " عندنا", "probability": 0.81396484375}, {"start": 1836.68, "end": 1836.96, "word": " أسلوب", "probability": 0.822021484375}, {"start": 1836.96, "end": 1837.14, "word": " في", "probability": 0.9462890625}, {"start": 1837.14, "end": 1837.16, "word": " ال", "probability": 0.94873046875}, {"start": 1837.16, "end": 1837.52, "word": " sheet", "probability": 0.8828125}, {"start": 1837.52, "end": 1838.92, "word": " بنحلها", "probability": 0.8118896484375}, {"start": 1838.92, "end": 1839.4, "word": " المحاضرة", "probability": 0.9906005859375}, {"start": 1839.4, "end": 1840.48, "word": " القادمة", "probability": 0.9928385416666666}, {"start": 1840.48, "end": 1841.92, "word": " لغاية", "probability": 0.989013671875}, {"start": 1841.92, "end": 1842.42, "word": " المحاضرة", "probability": 0.994384765625}, {"start": 1842.42, "end": 1842.88, "word": " القادمة", "probability": 0.9925130208333334}, {"start": 1842.88, "end": 1843.04, "word": " ان", "probability": 0.9443359375}, {"start": 1843.04, "end": 1843.24, "word": " شاء", "probability": 0.9931640625}, {"start": 1843.24, "end": 1843.42, "word": " الله", "probability": 0.94873046875}, {"start": 1843.42, "end": 1843.84, "word": " امتحان", "probability": 0.9328125}, {"start": 1843.84, "end": 1844.22, "word": " النص", "probability": 0.818603515625}, {"start": 1844.22, "end": 1844.68, "word": " فيه", "probability": 0.798583984375}, {"start": 1844.68, "end": 1846.6, "word": " انا", "probability": 0.5101318359375}, {"start": 1846.6, "end": 1846.78, "word": " كام", "probability": 0.8525390625}, {"start": 1846.78, "end": 1847.0, "word": " شبط", "probability": 0.60302734375}, {"start": 1847.0, "end": 1847.12, "word": " راح", "probability": 0.61474609375}, {"start": 1847.12, "end": 1847.64, "word": " يعدي؟", "probability": 0.67333984375}, {"start": 1847.64, "end": 1847.84, "word": " four", "probability": 0.72998046875}], "temperature": 1.0}, {"id": 64, "seek": 185411, "start": 1849.85, "end": 1854.11, "text": "لغاية يعني الموضوع هذا داخل في امتحان لأنه زي ما انتوا شايفين بسيط وسهل", "tokens": [1211, 17082, 995, 10632, 37495, 22653, 9673, 2407, 11242, 45367, 23758, 11778, 47283, 1211, 8978, 1975, 2304, 2655, 5016, 7649, 5296, 33456, 3224, 30767, 1829, 19446, 16472, 2655, 14407, 13412, 995, 33911, 9957, 4724, 3794, 1829, 9566, 46952, 3224, 1211], "avg_logprob": -0.11690167392172464, "compression_ratio": 1.29, "no_speech_prob": 2.384185791015625e-07, "words": [{"start": 1849.85, "end": 1850.51, "word": "لغاية", "probability": 0.9759521484375}, {"start": 1850.51, "end": 1850.93, "word": " يعني", "probability": 0.734375}, {"start": 1850.93, "end": 1851.27, "word": " الموضوع", "probability": 0.9962158203125}, {"start": 1851.27, "end": 1851.45, "word": " هذا", "probability": 0.416748046875}, {"start": 1851.45, "end": 1851.73, "word": " داخل", "probability": 0.9729817708333334}, {"start": 1851.73, "end": 1851.83, "word": " في", "probability": 0.86181640625}, {"start": 1851.83, "end": 1852.31, "word": " امتحان", "probability": 0.93515625}, {"start": 1852.31, "end": 1852.73, "word": " لأنه", "probability": 0.78857421875}, {"start": 1852.73, "end": 1852.85, "word": " زي", "probability": 0.904541015625}, {"start": 1852.85, "end": 1852.91, "word": " ما", "probability": 0.9658203125}, {"start": 1852.91, "end": 1853.07, "word": " انتوا", "probability": 0.744384765625}, {"start": 1853.07, "end": 1853.39, "word": " شايفين", "probability": 0.988037109375}, {"start": 1853.39, "end": 1853.77, "word": " بسيط", "probability": 0.9833984375}, {"start": 1853.77, "end": 1854.11, "word": " وسهل", "probability": 0.9191080729166666}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 1854.159875, "duration_after_vad": 1676.507499999996}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/kvXcLEwy9Ro_raw.srt b/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/kvXcLEwy9Ro_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..09dc141540843cf7cd505f20e04073adc1e8e19a
--- /dev/null
+++ b/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/kvXcLEwy9Ro_raw.srt
@@ -0,0 +1,1548 @@
+1
+00:00:00,000 --> 00:00:01,100
+موسيقى
+
+2
+00:00:20,870 --> 00:00:23,290
+أعوذ بالله السميع و العليم من الشيطان الرجيم بسم
+
+3
+00:00:23,290 --> 00:00:26,130
+الله الرحمن الرحيم الحمد لله والصلاة والسلام علي
+
+4
+00:00:26,130 --> 00:00:31,530
+مصطفى الأمين سيدنا محمد وعلى آله ومن ساره على دربه
+
+5
+00:00:31,530 --> 00:00:34,770
+بإحسان إلى يوم دين في البداية السلام عليكم ورحمة
+
+6
+00:00:34,770 --> 00:00:38,370
+الله كيف حالكوا؟ كيف أصبحتوا اليوم ان شاء الله
+
+7
+00:00:38,370 --> 00:00:42,110
+كويسين؟ اليوم ان شاء الله هناخد النقطة قبل الأخيرة
+
+8
+00:00:42,110 --> 00:00:44,850
+في ال chapter اللي بين إيدانا اللي هو ال close
+
+9
+00:00:44,850 --> 00:00:48,570
+point أو نقطة ash الإغلق هنشوف مع بعض إيش حكيلنا
+
+10
+00:00:48,570 --> 00:00:52,800
+تفضل يا غديرنقطة الإغلاق هي مستوى معين من النشاط
+
+11
+00:00:52,800 --> 00:00:56,680
+يمكن للشركة أن تستمر في ضلم منطقة الخسائر دون أن
+
+12
+00:00:56,680 --> 00:01:00,920
+تتعرض للتوقف إذا بس أسمع نقطة الإغلاق أو في مؤسسة
+
+13
+00:01:00,920 --> 00:01:06,500
+بتقولك معناها في خسائر لكن ممكن تستمر في الخسائر
+
+14
+00:01:06,500 --> 00:01:10,430
+لغاية ما تحس ان وضعها ممكن لأإذا لما يكون عندنا
+
+15
+00:01:10,430 --> 00:01:14,370
+خسارة أنا أمام حالتين فقط الحالة الأولى إما أستمر
+
+16
+00:01:14,370 --> 00:01:18,210
+بالوضع هذا و أحاول أني أنا أنقد نفسي و أنقد
+
+17
+00:01:18,210 --> 00:01:21,570
+المؤسسة أو إنه احنا خلاص نوصل لدرجة الإفلاس و
+
+18
+00:01:21,570 --> 00:01:26,610
+الخروج من السوق فضلي حيث تحمل الكمية .. حيث تحمل
+
+19
+00:01:26,610 --> 00:01:29,670
+الكمية خسائر ولكن الإيرادات تغطي التكاليف النقدية
+
+20
+00:01:29,670 --> 00:01:34,350
+للنشاط مما يضمن لها الاستمرار ليش احنا مستمرين؟
+
+21
+00:01:34,350 --> 00:01:38,590
+لأن إيراداتنا يعني مو في بيعبس بيع بسيط يعني، زي
+
+22
+00:01:38,590 --> 00:01:41,910
+الأيام هذه، الأيام هذه في حلم الكساد في السوق،
+
+23
+00:01:41,910 --> 00:01:46,470
+يدوب البيع يبيع كم من جطع بس عشان يغطي تكاليفه،
+
+24
+00:01:46,470 --> 00:01:51,950
+إذا الإيرادات يدوب تغطي تكاليف النقدية، يعني يبدو
+
+25
+00:01:51,950 --> 00:01:54,870
+القصارى جهدي بس يضال فاتحة المحل تبعي، فضلي.
+
+26
+00:01:55,230 --> 00:01:58,310
+التكاليف النقدية تساوي التكاليف التي تلتزم دفع
+
+27
+00:01:58,310 --> 00:02:02,160
+نقدي كالأجوز العالمية؟ تستلزمتستلزم دفع نقضي
+
+28
+00:02:02,160 --> 00:02:05,000
+كالأجور للعمال؟ أجور العمال لازم ندفعلهم cash،
+
+29
+00:02:05,000 --> 00:02:07,660
+مانفعش أعطيه مثلا شيك و كل وصف السنة اللي جاية،
+
+30
+00:02:07,660 --> 00:02:10,820
+مابثبتش و المراقبة و الصيانة و إيجار المباني و
+
+31
+00:02:10,820 --> 00:02:13,100
+مصالح المباني؟ ممتاز، الإيجار، الإيجار لازم يندفع
+
+32
+00:02:13,100 --> 00:02:18,440
+مثلا كل ست شهور، ماشي، مصاريف التنظيف مثلا، الميه
+
+33
+00:02:18,440 --> 00:02:21,300
+و التليفون و الكهرب، هذه لازم تتدفع باستمرار، إذا
+
+34
+00:02:21,300 --> 00:02:24,340
+في عدة متكاليف بنسميها نقضية صعب أني أراكمها أو
+
+35
+00:02:24,340 --> 00:02:30,660
+صعب أني أقول مش هدفعهمزي رواتب العمال أو الموظفين،
+
+36
+00:02:30,660 --> 00:02:35,580
+الأجور، الصيانة، الميّه، تليفون، الكهران تفضلي
+
+37
+00:02:35,580 --> 00:02:39,120
+التكاليف الغير نقدية تساوي الإهلاك إحنا ماعناش
+
+38
+00:02:39,120 --> 00:02:42,660
+تكلفة مش نقدية إلا حاجة واحدة الإهلاك، الإهلاك
+
+39
+00:02:42,660 --> 00:02:46,700
+عليه خلاف، فإن الإهلاك هو مش نقدي، تفضلي تساعد هذه
+
+40
+00:02:46,700 --> 00:02:50,340
+النقطة في اتخاذ قرار متى نغلق المصنع مؤقتا أو عدم
+
+41
+00:02:50,340 --> 00:02:54,060
+إغلاقه وذلك بمقارنة الخسارة المتوقعة لتوقف الإنتاج
+
+42
+00:02:54,060 --> 00:02:57,140
+والخسارة المتوقعة باستمرارهبكون عندنا يا أخوات
+
+43
+00:02:57,140 --> 00:03:02,340
+بديلين هل أنا أستمر في العمل ولا أجفل؟ أنا عندي
+
+44
+00:03:02,340 --> 00:03:06,240
+خسارة، الحالتين خسارة، الخسارة الأقل هي اللي بنان
+
+45
+00:03:06,240 --> 00:03:09,900
+عليها بتاخد إيش؟ القرار الخسارة الأقل هي اللي بنان
+
+46
+00:03:09,900 --> 00:03:18,780
+عليها بتاخد إيه القرار؟ في عندنا سؤال، أيوة، عندنا
+
+47
+00:03:18,780 --> 00:03:22,740
+سؤال، نشوف مع بعض، شكرا يا غدية، نشوف مع بعض إيش
+
+48
+00:03:22,740 --> 00:03:27,640
+ماتينا آية اسمها، اقرأينا البنو دي انتيركزوا معايا
+
+49
+00:03:27,640 --> 00:03:35,100
+خُلي بالك المبيعات 750 ألف دولار طولي بالك يعني
+
+50
+00:03:35,100 --> 00:03:38,660
+اللي هي الإيرادات لو قالك المبيعات بالدولار أو
+
+51
+00:03:38,660 --> 00:03:44,180
+الإيرادات هي نفسها .. نفس الاشي في أسئلة تانية
+
+52
+00:03:44,180 --> 00:03:50,720
+ممكن يقولنا المبيعات 75 ألف وحدة لأ مش هذه مش هذا
+
+53
+00:03:50,720 --> 00:03:55,150
+اللي بشتغل عليها أنا لازم أشتغل على الإيراداتطب لو
+
+54
+00:03:55,150 --> 00:03:58,950
+جالي 75 ألف وحدة هيكون معطينا معلومة زيادة اللي هي
+
+55
+00:03:58,950 --> 00:04:05,590
+السعر، ممتاز، إذا خدي بالك كويس، هل المبيعات مكتوب
+
+56
+00:04:05,590 --> 00:04:11,070
+وراها 750 ألف دولار، معناها الإيراد، لكن لو جالي
+
+57
+00:04:11,070 --> 00:04:17,850
+المبيعات 75 ألف وحدة، لأ مش هذا اللي بنشتغل عليها،
+
+58
+00:04:17,850 --> 00:04:21,150
+هلاقي معطيني معلومة زيادة اللي هي السعر، بضرب
+
+59
+00:04:21,150 --> 00:04:24,760
+المبيعات بالوحدة في السعر بجيب الإيراد،خدي بالك من
+
+60
+00:04:24,760 --> 00:04:27,580
+هذه النقطة لأن لو لا سامح الله مااخدتيش بالك الحل
+
+61
+00:04:27,580 --> 00:04:31,520
+كله على بعضه هكون غلط ليش هكون غلط؟ هتكون بتطرح
+
+62
+00:04:31,520 --> 00:04:35,260
+الوحدة من الدولارات و غلط الحل هذا تفضلي اسمها
+
+63
+00:04:35,260 --> 00:04:41,780
+موار مباشرة 250 ألف موار مباشرة 250 ألف جول مباشرة
+
+64
+00:04:41,780 --> 00:04:47,960
+180 ألفأجور مباشرة 180 ألف قوة محركة 70 ألف قوة
+
+65
+00:04:47,960 --> 00:04:52,400
+محركة اللي هي الوقود 70 ألف رواتب موظفين 140 ألف
+
+66
+00:04:52,400 --> 00:04:58,040
+اكت بجنبها تكاليف تابعة الرواتب زي ما شرحنا قبل
+
+67
+00:04:58,040 --> 00:05:02,740
+هيك تكاليف تابعة مواد أجور قوة متحركة أو قوة محركة
+
+68
+00:05:02,740 --> 00:05:07,660
+تكاليف متغيرة القوة المحركة اللي هي الوقود اللي هو
+
+69
+00:05:07,660 --> 00:05:11,290
+البنزين السولار بطلع بنزل يعني مش تابع تفضلمشروع
+
+70
+00:05:11,290 --> 00:05:16,410
+عمال السيانة 62500 هدى تكاليف إيش بالك؟ متغير
+
+71
+00:05:16,410 --> 00:05:22,810
+ممتاز يا نور إيجار مستحيل المصنع 25000 هي إيجار
+
+72
+00:05:22,810 --> 00:05:28,010
+مصنع، ممتاز، إنتاج، عفوًا، تابتة، ملاش علاقة
+
+73
+00:05:28,010 --> 00:05:31,330
+بالإنتاج، تفضلي كهربا أو ماء أو هاتف، كمان ثابت
+
+74
+00:05:31,330 --> 00:05:34,750
+إيه كتبي جنبها هدى عندي رسوم الكهربا والمية
+
+75
+00:05:34,750 --> 00:05:39,630
+والظواطب، عفوًا الهاتف، رسوم، إيه كتبي جنبها رسوم؟
+
+76
+00:05:39,630 --> 00:05:44,610
+ليش؟لأنه احنا أخدناها قبلك مختلطة جزء تابت وجزء
+
+77
+00:05:44,610 --> 00:05:49,170
+متغيّر ها لما نكتب رسوم بصير محسومة تابت على طول
+
+78
+00:05:49,170 --> 00:05:55,370
+ايوة اهلاك المعدات الاهلاك مش تكاليف نقدية بنحطه ع
+
+79
+00:05:55,370 --> 00:05:59,410
+جمع صح شرقا شكرا يا عزيزي ايش مطلوب مني احسب نقطة
+
+80
+00:05:59,410 --> 00:06:02,590
+الأقلاط في الدولار وانت مفهوم الشركة باستمرار في
+
+81
+00:06:02,590 --> 00:06:07,230
+أقلاط أقعدت عليك شكرا يا عزيزي هنحسب الآن مع بعض
+
+82
+00:06:07,230 --> 00:06:13,080
+اتك الخسارة اللي أقلسواء كان إستمرار أو إغلاق هو
+
+83
+00:06:13,080 --> 00:06:17,380
+اللي هننصح فيه إذا لما يقول لي أحسبي نقطة الإغلاق
+
+84
+00:06:17,380 --> 00:06:20,780
+بدي أجي في بالي أنه هيطلع السؤال خسران الحال خسارة
+
+85
+00:06:20,780 --> 00:06:26,220
+و بنختار الخسارة إيش؟ الأقل نحل السؤال شوي شوي مع
+
+86
+00:06:26,220 --> 00:06:38,800
+بعض واحد نقطة الإغلاق قانون صغنون بالساول التكاليف
+
+87
+00:06:38,800 --> 00:06:39,840
+التابعة النقدية
+
+88
+00:06:43,770 --> 00:06:50,650
+تقسيم عائد المساهمة حد
+
+89
+00:06:50,650 --> 00:06:57,910
+ساوي التكاليف التابعة النقدية بتساوي
+
+90
+00:06:57,910 --> 00:07:04,150
+الإيراد ناقص التكاليف المتغيرة حد ساوي طبعا أنا
+
+91
+00:07:04,150 --> 00:07:09,870
+بحل بالتفصيليلا يا إسراء الزعنون شوفينا يا أنتي
+
+92
+00:07:09,870 --> 00:07:13,030
+إيش التكاليف التابتة و اللي ازميلتك أسمان بتقرا في
+
+93
+00:07:13,030 --> 00:07:17,270
+السؤال قولنا هادي تابتة هادي تابتة رواتب موظفين
+
+94
+00:07:17,270 --> 00:07:23,450
+أكتب يعني رواتب ولا أكتب لرقام على طول؟ لرقام على
+
+95
+00:07:23,450 --> 00:07:33,190
+طول 149 في حد تاني قولنا تابت؟ ممتاز
+
+96
+00:07:33,190 --> 00:07:38,170
+يا أنتي ضايلة واحدة عشر تلاتةممتاز اللي هي رسوم
+
+97
+00:07:38,170 --> 00:07:41,570
+الكهربا والميه والتليفون في حد بيسأل نفسه شو معنى
+
+98
+00:07:41,570 --> 00:07:47,850
+هدول؟ هدول التكاليف الاش؟ التابتة أعيدها؟ طبعا
+
+99
+00:07:47,850 --> 00:07:50,570
+بيكون واضح فيش بيصير عنا لابس مين تابت ومين متغير
+
+100
+00:07:50,570 --> 00:07:53,510
+لإن أحنا شرحنا الموضوع هذا في chapter كامل عقد
+
+101
+00:07:53,510 --> 00:07:56,170
+المسامل هو الإيراد شكرا يا إسراء الزعنون إسراء
+
+102
+00:07:56,170 --> 00:07:59,970
+الدبور الإيراد قداشو السؤال؟ الإيراد هو المبيعات
+
+103
+00:07:59,970 --> 00:08:02,390
+754 ممتاز شكرا يا إسراء
+
+104
+00:08:06,500 --> 00:08:09,860
+شكرا يا auntie أحلام .. قداش .. انتي التكاريف
+
+105
+00:08:09,860 --> 00:08:13,600
+المتغيرة ممكن نطلعها سوا؟ أه أول إشي بتطفع 250 ألف
+
+106
+00:08:13,600 --> 00:08:18,100
+نفتح قاص؟ أه زائد عشان أكتر 250 ألف اللي هي مين
+
+107
+00:08:18,100 --> 00:08:22,180
+هذه؟ مواد مباشرة مواد مباشرة زائد أجور مباشرة 180
+
+108
+00:08:22,180 --> 00:08:29,920
+ألف 180 ألف زائد و القوة المحركة 70 ألف 70 ألف و
+
+109
+00:08:29,920 --> 00:08:32,000
+الأجور العمال والصيانة؟
+
+110
+00:08:34,060 --> 00:08:39,780
+ستة، اثنين، خمسة، زي، زي، زي، ضايل؟ لا، خلصت إسقطت
+
+111
+00:08:39,780 --> 00:08:42,440
+لحظة الإهلاق مابتنحط فيها الإهلاق مابنحطش في
+
+112
+00:08:42,440 --> 00:08:49,660
+الحساب المعادلة إهلاق
+
+113
+00:08:49,660 --> 00:08:51,400
+إذا بدنا نحسب قانون الداخل مابنحطه فيه لكن هو
+
+114
+00:08:51,400 --> 00:08:54,440
+مابنحطش في القانون ليش؟ لأنه غير نقدي مش cash
+
+115
+00:08:54,440 --> 00:08:58,200
+الإهلاق مش cash الإهلاق حاجة منموسة يعني أنا اليوم
+
+116
+00:08:58,200 --> 00:09:04,090
+شرت آلةأو مثلا اشتراه
+
+117
+00:09:04,090 --> 00:09:06,750
+اعلى بس مش هو مشكلة انك تشتري اعلى صحيح مثلا
+
+118
+00:09:06,750 --> 00:09:13,290
+أسمهان شرت جوال ب 3000 شكل صارله معها سنة استخدمته
+
+119
+00:09:13,290 --> 00:09:19,730
+لما كتش تبيعه هل هتبيعه ب 3000؟ لأ يمكن تبيعه
+
+120
+00:09:19,730 --> 00:09:25,490
+ب2000 او 1500 إذا الفرق بين سعر شراء الجوال هو
+
+121
+00:09:25,490 --> 00:09:30,060
+جديدوعملية البيع بعد ما استهلكته هذا اشي معنوي هذا
+
+122
+00:09:30,060 --> 00:09:33,160
+اشي احنا بنلبسه لمس مش انه اه هاي خد هاي الهلاك
+
+123
+00:09:33,160 --> 00:09:37,680
+واضح؟ الهلاك تكاليف غير نقضية تكاليف غير نقضية
+
+124
+00:09:37,680 --> 00:09:45,360
+طلعولنا الناتج لو سمحتوا 700 ألف دولار
+
+125
+00:09:45,360 --> 00:09:51,820
+ولا واحدة؟ دولار ممتاز لأن كل الأرقام اللي احنا
+
+126
+00:09:51,820 --> 00:09:56,120
+حسبناها بإيش؟ بالدولار ماشي؟
+
+127
+00:09:58,300 --> 00:10:06,000
+إذا بيقولي عند 700 ألف دولار لأ
+
+128
+00:10:06,000 --> 00:10:14,400
+لأ لسه ما تاخدناش القرار عند 700 ألف دولار المؤسسة
+
+129
+00:10:14,400 --> 00:10:24,800
+تقف بالمفترق طريق إما إنها تستمر في خسرانة أو إنها
+
+130
+00:10:24,800 --> 00:10:31,040
+تتسكرإذا خُد يبقى بالك السؤال طالب شغلتين احسبي
+
+131
+00:10:31,040 --> 00:10:33,800
+نقطة اغلاق هذه الشركة نقطة اغلاق هذه الشركة من
+
+132
+00:10:33,800 --> 00:10:38,440
+سبعمائة ألف دولار يعني عند الرقم هذا خسارة أنا
+
+133
+00:10:38,440 --> 00:10:44,320
+قاعدة بخسر واضح؟ طب انصحينا بناء معلوماتك وعلمك إن
+
+134
+00:10:44,320 --> 00:10:49,640
+دلنا نخسر هل لو عسى نتصلح في المستقبل ولا نسكر
+
+135
+00:10:49,640 --> 00:10:53,880
+خلاص نسحب من السوق؟مش تحذيري وانتي عشان اجابع
+
+136
+00:10:53,880 --> 00:10:57,360
+السؤال لازم نعمل قائمة الدخل لازم نعمل .. لازم هذا
+
+137
+00:10:57,360 --> 00:11:01,140
+ال .. هذا الشركة ربحانة مش هيعطيك السؤال هذا يا
+
+138
+00:11:01,140 --> 00:11:04,640
+نور بس لأ يعني هيكون في نقطة اغلاق .. لأ ربحانة
+
+139
+00:11:04,640 --> 00:11:08,840
+مرة تانية لما تكون الشركة ربحانة مش هيعطيك السؤال
+
+140
+00:11:08,840 --> 00:11:12,940
+ليش؟ لأن نقطة اغلاق احنا بندرسها في الخسارة فقط
+
+141
+00:11:14,340 --> 00:11:17,100
+يعني انت ربحانة او الله فاتحها لك؟ فاتحها لك؟
+
+142
+00:11:17,100 --> 00:11:19,760
+بتاخد بيبيوتك بايدك ولا ايش؟ ممكن انا اجيبله سؤال
+
+143
+00:11:19,760 --> 00:11:22,520
+ربحت و احنا مش متبهين بالبخار فمش فاهم .. والله
+
+144
+00:11:22,520 --> 00:11:24,140
+انتوا اللي جابتولي السؤال طوال .. انا مالاش عبالي
+
+145
+00:11:24,140 --> 00:11:27,480
+السؤال قبلك ممكن اجيبليه .. لأ لأ .. نقطة الإغلاق
+
+146
+00:11:27,480 --> 00:11:33,060
+دائما بتكون المؤسسة خسرانة دائما ماحدش بيكون ربحان
+
+147
+00:11:33,060 --> 00:11:37,860
+و مبسوط و بروح بيسكر تعالوا نساعدهم في اتخاذ
+
+148
+00:11:37,860 --> 00:11:42,940
+القرار هل احنا نستمر في الخسارة ولا لأ ساكروا يا
+
+149
+00:11:42,940 --> 00:11:49,220
+جماعة؟وشوفولكوا حاجة تانية و لا ببرزك تاني أعيد يا
+
+150
+00:11:49,220 --> 00:11:53,480
+أخوات و لا كيف؟ أعيد إيش معا نقطة الغلاق؟ شركة
+
+151
+00:11:53,480 --> 00:11:57,280
+خسران، واحد خسران، والله أنا قاعد بخسر يا أبا أضل
+
+152
+00:11:57,280 --> 00:12:00,380
+أخسر و لا أسكر؟ ما أنتي دراسة تجارة؟ بنعمل حسبة
+
+153
+00:12:00,380 --> 00:12:03,860
+صغيرة، بنتخد القرار، يلا بنعمل حسبة هروح يا أخوات
+
+154
+00:12:03,860 --> 00:12:12,020
+رسم قائمة الدخل بعد الشكل، هقول في حالة الاستمرار
+
+155
+00:12:13,490 --> 00:12:21,770
+في حالة الإغلاق أو التوقف إذا أنا بدي أنصح التأجير
+
+156
+00:12:21,770 --> 00:12:27,850
+الخسراني بشغلة واحدة هو خسران إما يستمر خليك و
+
+157
+00:12:27,850 --> 00:12:31,070
+الله يفرجها و وضعك يعني أحسن من غيرك أو لا و الله
+
+158
+00:12:31,070 --> 00:12:36,650
+يسكر و يشوفك رزق تاني تعالوا نبدأ نعمل قامة إيش
+
+159
+00:12:36,650 --> 00:12:42,590
+الدخل عندنا هنا الإيراد تكاليف متغيرة
+
+160
+00:12:45,410 --> 00:12:51,670
+مجمع للربح تكاليف تابعة اللي هي لك بظهر هنا الصف
+
+161
+00:12:51,670 --> 00:12:58,250
+النتيجة مش طالع؟ ماشي الصف
+
+162
+00:12:58,250 --> 00:13:03,510
+النتيجة طبعا هي خسارة في حاجة السمرانة كده شرادنا
+
+163
+00:13:03,510 --> 00:13:09,050
+هيكون؟ 75 أعني سبعمية و .. سبعمية و .. سبعمية و
+
+164
+00:13:09,050 --> 00:13:14,830
+خمسين أعني بجيب من الجدول أنا لو أتوقفناهتوقفنا
+
+165
+00:13:14,830 --> 00:13:19,150
+خلاص بطل تبيع خودي بالك في حالة التوقف في الشبايع
+
+166
+00:13:19,150 --> 00:13:24,070
+يعني زيره ماشي طيب جداش التكليف المتغير اللي هي ال
+
+167
+00:13:24,070 --> 00:13:26,550
+bus .. المقام عصمه اللي كان هان جداش كله ع بعضه
+
+168
+00:13:26,550 --> 00:13:32,990
+كان؟ المقام اللي حانه؟ أه بتلا أه حسبته حسبتيه يلا
+
+169
+00:13:32,990 --> 00:13:36,770
+أعطينا يانا أعطي 157500
+
+170
+00:13:49,600 --> 00:13:53,000
+بدال فيش يراد يعني مافيش انتاج معناه مافيش تكليف
+
+171
+00:13:53,000 --> 00:13:58,080
+مرتغير اذا zero zero zero خلاص يعني سكر اطرحولنا
+
+172
+00:13:58,080 --> 00:14:01,380
+لإن بنقسم طالع 750 ناقص 500 تطلع بالموجة
+
+173
+00:14:06,510 --> 00:14:09,510
+التكليف الداب داب برضه اللي هو كان ال bus بتاعنا
+
+174
+00:14:09,510 --> 00:14:21,090
+أخدت
+
+175
+00:14:21,090 --> 00:14:24,830
+بارف لما توقفنا ما دفعنا إيراد ولا تكليف متغيرة
+
+176
+00:14:24,830 --> 00:14:28,270
+ماعناش رباح لكن باخد بقالي اعتبار التكليف الاش
+
+177
+00:14:28,270 --> 00:14:30,590
+تكلفة الداب تكلفة الداب صح في النتيجة هاد هتنزل زي
+
+178
+00:14:30,590 --> 00:14:34,690
+ما هي عشان هالحالها هادي احسبوها لو هاد الـ
+
+179
+00:14:38,460 --> 00:14:45,220
+انتوا عطيطوني رقم هي 145 ألف صح؟ لأ صح مش صح 140
+
+180
+00:14:45,220 --> 00:14:52,020
+ألف زي 25 ألف زي 10 تلات 175 مش
+
+181
+00:14:52,020 --> 00:14:58,120
+140 نعطيك ألف مليون أربعمائة و خمسين 140 ألف 140
+
+182
+00:14:58,120 --> 00:15:03,040
+ألف 140
+
+183
+00:15:03,040 --> 00:15:05,860
+ألف الناس حاضر يا أنت بدي أوضح من وين هيمي
+
+184
+00:15:16,160 --> 00:15:21,400
+شكرا على التوضيح و التنبيه يا انت احسب الاهلاك يا
+
+185
+00:15:21,400 --> 00:15:25,960
+جماعة انا جيت اكتبوا عواد كنت لحاجة اللي اخلي
+
+186
+00:15:25,960 --> 00:15:28,800
+معاهم وانسيت اللي احكيه الاهلاك من هنا جت 190
+
+187
+00:15:28,800 --> 00:15:36,420
+الاهلاك فقط فقامت الداخل زي ما حكوا البنات التو في
+
+188
+00:15:36,420 --> 00:15:41,710
+حد بيسأل حاجة من ال 190 مع الاهلاك2500 ولا 25000
+
+189
+00:15:41,710 --> 00:15:47,530
+دلال
+
+190
+00:15:47,530 --> 00:15:51,990
+ايش بتنصحينا يا انتي بناء على الدراسة اللي عملنا؟
+
+191
+00:15:51,990 --> 00:15:57,290
+مين اقل .. مين اقل خسارة؟ الاستمرار احسن لإنه لو
+
+192
+00:15:57,290 --> 00:16:01,470
+اغلطنا بنخسر بزيادة يعني الوضع التام يعني حاليا
+
+193
+00:16:01,470 --> 00:16:04,690
+انه مانسكت احسن ماشي مش جامع طبعا الاستمرار هو
+
+194
+00:16:04,690 --> 00:16:09,210
+النصيحة حسب الأرقام ننصح نكتب التعليق؟
+
+195
+00:16:12,640 --> 00:16:20,080
+ننصح صاحب هذه المؤسسة بالاستمرار
+
+196
+00:16:20,080 --> 00:16:26,200
+وذلك لإمكانية
+
+197
+00:16:26,200 --> 00:16:36,140
+تحسين وضع الشركة في المستقبل وهذا
+
+198
+00:16:36,140 --> 00:16:39,260
+ما يحصل
+
+199
+00:16:43,820 --> 00:16:52,760
+الان في الأسواق المحلية هذا
+
+200
+00:16:52,760 --> 00:16:56,380
+اللي بيصير عرض الواقع يدوب يبيع هالقطعتين عشان
+
+201
+00:16:56,380 --> 00:16:59,680
+يدفع زي ما هو عندنا عصابوها ذواتب، الإيجار،
+
+202
+00:16:59,680 --> 00:17:04,560
+الكهربا أه أه، مافيش يا داني، ما هو بقعد أحسن مني
+
+203
+00:17:04,560 --> 00:17:08,260
+أخرج من السوق ويخرج من السوق مش بسيط، توقع عندنا
+
+204
+00:17:08,260 --> 00:17:09,340
+شيط يا أخوات؟
+
+205
+00:17:13,200 --> 00:17:18,380
+اه هي سؤال أول صفحه اتنين السؤال الأول شركة نورس
+
+206
+00:17:18,380 --> 00:17:25,200
+مين يطلع؟ أخر
+
+207
+00:17:25,200 --> 00:17:27,560
+حاجة ان شاء الله في المحاضرة اليوم و في هذا ال
+
+208
+00:17:27,560 --> 00:17:32,880
+chapter اللي هو تحليل الحساسية تحليل إيش؟ الحساسية
+
+209
+00:17:34,570 --> 00:17:38,230
+تحب تقلق أيه؟ تفضل يا عزيزي، تفضل التحليق الحساسية
+
+210
+00:17:38,230 --> 00:17:41,790
+هو التحليق اللي يرافع بين التكاليف وحجم النشاط
+
+211
+00:17:41,790 --> 00:17:45,190
+والأرباح ومعرفة هذا تأثير التغيير في العوامل
+
+212
+00:17:45,190 --> 00:17:48,830
+متعاملة بالتكاليف والأسعار والكيميات والأرباح ورقم
+
+213
+00:17:48,830 --> 00:17:52,950
+التعادل التغيير قد يكون في رانصر واحد أو أخر شكرا
+
+214
+00:17:52,950 --> 00:17:59,410
+يا عزيزي تحليق الحساسية هي أخوات ببساطة بنحسب نقطة
+
+215
+00:17:59,410 --> 00:18:01,610
+التعادل زي ما اتعودنا اللي هي التكاليف التالتة
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+216
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+تقسم السعر لنقص تكليف متقالة لوحدهاوبعدين بصير
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+217
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+السؤال يقول لي لو السعر زاد نقطة تعادل إيش هيصير
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+218
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+فيها الله أعلم نحسب طب لو التكليف المتغيرة قلت
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+219
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+مثلا طب لو اتنين زادوا إذا تحليل الحساسية درجة
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+220
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+221
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+زودنا مثلا سعر لو زودنا التكليف المتغيرة لو زودنا
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+222
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+التكليف التابتة إيش هيصير في نفس الناتج تعالوا
+
+223
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+ناخد سؤالههيل معاكوا بندين و بتكملوا انتوا لحالكوا
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+224
+00:18:38,350 --> 00:18:44,710
+عادي لأنه سهل شوفوا معا بعض السؤال نرجع
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+225
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+226
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+كان بي تلاتين و
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+227
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+
+228
+00:19:03,250 --> 00:19:10,290
+عشرينفيه يا جماعة التكليف المتغير الواحدة فيه و FC
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+229
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+عشر تلاف هي
+
+230
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+السؤال بس احسبي نقطة التعادل حسب
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+231
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+المعطيات السابقة وفي
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+232
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+الحالات الآتية واحد
+
+233
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+إذا ارتفعت التكاليف التابعة إلى خمسة في المية طب
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+234
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+على الارتفاع سهم لأعلى، مابكتبش ارتفعة، سهم لأعلى،
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+اثنين سهم
+
+236
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+
+242
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+
+243
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+زيادة ال price 10% ستة انخفاض ال price 10% سهم
+
+244
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+الأسفل 10% سبعة
+
+245
+00:20:52,570 --> 00:20:56,070
+زيادة
+
+246
+00:20:56,070 --> 00:21:03,910
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+
+247
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+وزيادة السعر 10% بكفي؟ انحل أول واحدة نشوف كيف سهل
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+248
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+249
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+250
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+255
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+256
+00:22:01,610 --> 00:22:08,990
+عشرين بتساوي ألف واحد you
+
+257
+00:22:08,990 --> 00:22:15,330
+or you not؟ you you not؟ طيب شكرا لغاديا الحالة
+
+258
+00:22:15,330 --> 00:22:20,390
+الأولى إسلام
+
+259
+00:22:20,390 --> 00:22:26,270
+إيش كان في الحالة الأولى؟
+
+260
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+حل على طول break even هتساوي نفتح pasta مقارنة
+
+261
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+264
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+265
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+جديش عندك التكريف بتاع تسلام؟ عشر تلاف عشر تلاف
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+266
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+زائد نفتح قصة عشر تلاف جديش التغير؟ خمسة في المية
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+267
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+
+268
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+عشرين عشرين عشرين عشرين عشرين عشرين عشرين عشرين
+
+269
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+عشرين عشرين عشرين عشرين عشرين عشرين عشرين عشرين
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+270
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+عشرين عشرين عشرين عشرين عشرين عشرين عشرين عشرين
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+271
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+عشرين عشرين عشرين عشرين
+
+272
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+هى هى اللى بدى احقالة؟ خمسمية ولا كدهش؟ خمسمية
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+273
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+خمسمية خدتى
+
+274
+00:23:44,380 --> 00:23:48,420
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+
+275
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+بعد الزيادة؟ خمسمية؟ لأ مش الف عشرة تلاف وخمسمية
+
+276
+00:23:51,940 --> 00:23:55,400
+عشرة تلاف وخمسمية لأ جازى كله لأ كله لكوا الناتج
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+277
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+يعنى
+
+278
+00:24:06,020 --> 00:24:08,960
+يعني بقى زيادة التكاليف الت .. التكاليف .. نقطة
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+279
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+بتاعك اتحركت ناحية اليمين يعني زادت زادت ماشي يعني
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+280
+00:24:14,040 --> 00:24:19,320
+إيش؟ زادت سهل ولا صعب؟ سهل صح ناخد كمان واحدة عظيم
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+281
+00:24:19,320 --> 00:24:24,360
+شفون التكاليف المتغير هتول ما نخفضها نمسك التكاليف
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+282
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+المتغير ونعود لدراسة في
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+283
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+حاجة
+
+284
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+هنا .. في سؤال؟ليش بت .. يعني ال FC رمز التكاليف
+
+285
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+الثالث صح؟ ماله؟ مش .. يعني هو رمزه هيك ولا مش كان
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+286
+00:24:43,660 --> 00:24:49,100
+الاشي تاني؟ لا .. مش الاشي التاني بالعربي ب .. ب
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+287
+00:24:49,100 --> 00:24:50,640
+.. ب .. ب .. ب .. ب .. ب .. ب .. ب .. ب .. ب .. ب
+
+288
+00:24:50,640 --> 00:24:50,660
+.. ب .. ب .. ب .. ب .. ب .. ب .. ب .. ب .. ب .. ب
+
+289
+00:24:50,660 --> 00:24:50,660
+.. ب .. ب .. ب .. ب .. ب .. ب .. ب .. ب .. ب .. ب
+
+290
+00:24:50,660 --> 00:24:51,080
+.. ب .. ب .. ب .. ب .. ب .. ب .. ب .. ب .. ب .. ب
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+291
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+.. ب .. ب .. ب .. ب .. ب .. ب .. ب .. ب .. ب .. ب
+
+292
+00:24:51,800 --> 00:24:52,180
+.. ب .. ب .. ب .. ب .. ب .. ب .. ب .. ب .. ب .. ب
+
+293
+00:24:52,180 --> 00:24:56,340
+.. ب .. ب .. ب .. ب .. ب .. ب .. ب .. ب .. ب .. ب
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+294
+00:24:56,340 --> 00:24:56,340
+.. ب .. ب .. ب .. ب .. ب .. ب .. ب .. ب .. ب .. ب
+
+295
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+..
+
+296
+00:25:04,710 --> 00:25:09,690
+كملوا ولا نستنى؟ طبعا كل هدف هادي يلا يا آية
+
+297
+00:25:09,690 --> 00:25:13,690
+العوضي تكليف المتغيرة بدنا انخفاضها اعطاكي في
+
+298
+00:25:13,690 --> 00:25:18,550
+السؤال تكليف
+
+299
+00:25:18,550 --> 00:25:20,670
+الثابت انا مش هنتغير ايامك لأ انا مش هنحل
+
+300
+00:25:20,670 --> 00:25:25,930
+بالتراتيب حلوا لحالكوا اللي هي الرقم أربعة قداشي
+
+301
+00:25:25,930 --> 00:25:32,430
+آية اللي هوضي رقم أربعة في السؤال هنحل
+
+302
+00:25:32,430 --> 00:25:36,830
+الحالة رقم أربعةالتكليف المتغير انخفضت عشرة فمية
+
+303
+00:25:36,830 --> 00:25:40,590
+في حاجة دلال؟ لإن اسمه بس عدش اللي جانب ال unit ال
+
+304
+00:25:40,590 --> 00:25:46,050
+U إيش هذا ال unit نفس
+
+305
+00:25:46,050 --> 00:25:49,250
+القانون يا أخواتنا طبعا إحنا هنا عندنا تكليف متغير
+
+306
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+اتغيرت حد ساوت تكليف التابعة مالهاش دعوة تقصين ال
+
+307
+00:25:55,870 --> 00:26:05,980
+price مالوش دعوة ناقص ال Vc ناقص ناقص ناقصال في سي
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+308
+00:26:05,980 --> 00:26:11,960
+ضرب نسبة التغير يلا
+
+309
+00:26:11,960 --> 00:26:16,780
+نعوض دي آية، كداش ال fc؟ عشرة تلاف عشرة تلاف، كداش
+
+310
+00:26:16,780 --> 00:26:26,120
+سعرك؟ تلاتين ناقص، ال في سي؟ عشرين عشرين ناقص؟
+
+311
+00:26:26,120 --> 00:26:32,250
+عشرين ضرب عشرة ثانية ممتاز، حسبولها لو سمحتوا833
+
+312
+00:26:32,250 --> 00:26:39,990
+كله على بعضه؟ اه 833 اذا
+
+313
+00:26:39,990 --> 00:26:43,610
+لاحظنا لما التكاليف المتغير انها خفضت نقطة التعادل
+
+314
+00:26:43,610 --> 00:26:51,950
+قلت من 1000 ل 833 سهلة
+
+315
+00:26:51,950 --> 00:26:53,110
+ولا صعبة؟ سهلة
+
+316
+00:26:58,400 --> 00:27:02,020
+سهل و لا صعب؟ سهل سهل نعمل كمان واحدة و لا خلاص؟
+
+317
+00:27:02,020 --> 00:27:05,280
+برجعلكوا
+
+318
+00:27:05,280 --> 00:27:09,940
+ماعنديش مشكلة أنا نعم
+
+319
+00:27:09,940 --> 00:27:16,120
+يا إسراء؟ تطلع تحلو يعني؟ مين يطلع يحل الحالة
+
+320
+00:27:16,120 --> 00:27:21,480
+الأخيرة؟ الحالة الأخيرة؟ مين كمان؟ اتفضلي يا هديل،
+
+321
+00:27:21,480 --> 00:27:26,520
+اخوني معها دي سرعة لو سمحتي الحالة الأخيرة فيها
+
+322
+00:27:26,520 --> 00:27:30,520
+كذا تغيرحلوة تانية اللي هو ارتفاع تكلفة كتابك لـ 5
+
+323
+00:27:30,520 --> 00:27:36,560
+%؟ نعم، 5% وين؟ ممتاز، خد يا عم تاجرها برمجة 10%
+
+324
+00:27:36,560 --> 00:27:44,920
+هيك
+
+325
+00:27:44,920 --> 00:27:51,700
+بنكون خلصنا هذا الفصل إن شاء الله طبعا، هنعمل فيه
+
+326
+00:27:51,700 --> 00:27:52,020
+quiz
+
+327
+00:28:04,480 --> 00:28:07,940
+أي حالة يا حلوة؟ الأخيرة .. الأخيرة يعني ..
+
+328
+00:28:07,940 --> 00:28:16,100
+الأخيرة وقتها إيش حابين ال quiz يا عيا سامون؟ يوم
+
+329
+00:28:16,100 --> 00:28:21,740
+الأربع القادم؟ ان شاء الله في الشبطة تلاتة بس، كيك
+
+330
+00:28:21,740 --> 00:28:25,480
+بتكونوا ذكاته كل نصفة؟ على تلات شبطة
+
+331
+00:28:30,140 --> 00:28:35,520
+حابين أكتر؟ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ
+
+332
+00:28:35,520 --> 00:28:37,520
+لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ
+
+333
+00:28:37,520 --> 00:28:40,400
+لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ
+
+334
+00:28:40,400 --> 00:28:40,440
+لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ
+
+335
+00:28:40,440 --> 00:28:40,560
+لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ
+
+336
+00:28:40,560 --> 00:28:40,560
+لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ
+
+337
+00:28:40,560 --> 00:28:44,120
+لأ لأ لأ لأ لأ لأ لأ لأ لأ
+
+338
+00:28:44,120 --> 00:28:52,520
+لأ
+
+339
+00:28:56,370 --> 00:28:59,590
+هك أنا مطمئنة عليك و لإنه عملنا quiz في أول
+
+340
+00:28:59,590 --> 00:29:02,750
+chapter نعمل كمان quiz بتكونوا مذاكرين المادة كلها
+
+341
+00:29:02,750 --> 00:29:15,110
+هكذا اعطوها
+
+342
+00:29:15,110 --> 00:29:21,970
+النتج لو سمحتوا لا شكرا نتكي انا مش شايفها شكرافي
+
+343
+00:29:21,970 --> 00:29:25,890
+حد مشروع حاجة؟ آية هدى؟ مش .. مش .. مش .. ال .. ال
+
+344
+00:29:25,890 --> 00:29:31,770
+price يرتفع عشرة في الانهيار لازم نضرب الحشرة اشي
+
+345
+00:29:31,770 --> 00:29:38,430
+الحالة اللى هى حلتها؟ التلاتة سوا، إذن السر متغير
+
+346
+00:29:38,430 --> 00:29:46,610
+يعنى؟ صلحينا الحل لو سمحتى يعني التلاتة عناصر
+
+347
+00:29:46,610 --> 00:29:54,990
+تعانوا التعادل وتغيروالأ فضل يعني حد
+
+348
+00:29:54,990 --> 00:29:59,970
+عنده سؤالة و يستفسر؟ انتي حلوة
+
+349
+00:30:07,690 --> 00:30:11,650
+الثلاثين زائد .. ثلاثين زائد ولا قلت؟ زائد .. زائد
+
+350
+00:30:11,650 --> 00:30:13,450
+.. زائد .. زائد .. زائد .. زائد .. زائد .. زائد ..
+
+351
+00:30:13,450 --> 00:30:13,830
+زائد .. زائد .. زائد .. زائد .. زائد .. زائد ..
+
+352
+00:30:13,830 --> 00:30:15,370
+زائد .. زائد .. زائد .. زائد .. زائد .. زائد ..
+
+353
+00:30:15,370 --> 00:30:16,890
+زائد .. زائد .. زائد .. زائد .. زائد .. زائد ..
+
+354
+00:30:16,890 --> 00:30:18,770
+زائد .. زائد .. زائد .. زائد .. زائد .. زائد ..
+
+355
+00:30:18,770 --> 00:30:19,150
+زائد .. زائد .. زائد .. زائد .. زائد .. زائد ..
+
+356
+00:30:19,150 --> 00:30:21,730
+زائد .. زائد .. زائد .. زائد .. زائد .. زائد ..
+
+357
+00:30:21,730 --> 00:30:29,190
+زائد .. زائد .. زائد .. زائد .. زائد .. زائد
+
+358
+00:30:29,190 --> 00:30:34,320
+.. زأيوة؟ حطي زائد جنب التلاتين افتح قص صغنون
+
+359
+00:30:34,320 --> 00:30:42,060
+تلاتين ضرب عشرة بالمية اه second قص حطي قص كبير من
+
+360
+00:30:42,060 --> 00:30:45,260
+عند تلاتين لأخر قص لصغير ايوة؟ لأ من عند تلاتين
+
+361
+00:30:45,260 --> 00:30:51,760
+تلاتين لأ لأ ايوة؟ جداش الناتج لو سمحتوا؟
+
+362
+00:30:51,760 --> 00:30:58,140
+جداش الناتج؟ صح اه ولا .. صح يا إساء؟
+
+363
+00:31:06,460 --> 00:31:13,000
+مش فاهمة؟ ماشي كان عندنا الحلقة لقم سبعة فيها ماشي
+
+364
+00:31:13,000 --> 00:31:20,760
+كل يوم انت فيها تلات .. تلات شغلات تكليف
+
+365
+00:31:20,760 --> 00:31:22,600
+التابتة زادت خمسة في المية
+
+366
+00:31:26,910 --> 00:31:36,510
+التكاليف المتغيرة انخفضت 10% السعر زاد 10% بس اللي
+
+367
+00:31:36,510 --> 00:31:40,070
+بزيد جمع اللي بنقص طرحه بس هاي اللي .. هاي اللي
+
+368
+00:31:40,070 --> 00:31:47,450
+صار يعني واضحة؟ أعيد الحل؟ أعيده تاني؟ بعيده مش
+
+369
+00:31:47,450 --> 00:31:53,390
+مشكلة أعيده؟ هيساوي؟
+
+370
+00:31:54,420 --> 00:31:56,940
+تكليف التاب بتاعنا احنا عشرة تلاف بيقولوا انها
+
+371
+00:31:56,940 --> 00:32:00,320
+زايدة هي عشرة تلاف ضرب خمسة في المية اللي هي
+
+372
+00:32:00,320 --> 00:32:04,660
+الزيادة ستمية ستة و ستين ماشي عندي زاد لعشرة تلاف
+
+373
+00:32:04,660 --> 00:32:08,500
+السعر
+
+374
+00:32:08,500 --> 00:32:14,920
+بيقولوا انه زاد عشرة في المية نفس الجثة تلاتين ضرب
+
+375
+00:32:14,920 --> 00:32:18,360
+عشرة في المية زائد
+
+376
+00:32:19,750 --> 00:32:24,830
+تلاتين ناقص تقريبا
+
+377
+00:32:24,830 --> 00:32:30,910
+تغير لعشرين في عشرة فالمية ناقص
+
+378
+00:32:30,910 --> 00:32:36,290
+عشرين بس طب انا بتطلع كل ناتج لحالي دهش بيعطيني حل
+
+379
+00:32:36,290 --> 00:32:42,870
+توي سمعتاش تاني يعني مفروض يجيبوا نفس الناتج يا
+
+380
+00:32:42,870 --> 00:32:50,660
+جماعة جداش يجيبوا نفس الناتجيله يا جماعة عال ميديك
+
+381
+00:32:50,660 --> 00:33:03,400
+على السرعة جداش
+
+382
+00:33:03,400 --> 00:33:11,440
+يا اسمها؟ شوية شوية جداش ال bus بتطلع؟ هاي عشر
+
+383
+00:33:11,440 --> 00:33:16,980
+تلاف و خمس مية اه سبعمية يا مس و المقام؟ خمستاشر
+
+384
+00:33:16,980 --> 00:33:23,540
+خمستاشر سبعميةهذه؟ لأ هذه كانت تلاتة و تلاتين و
+
+385
+00:33:23,540 --> 00:33:28,360
+بعدها تلانتاشر هذي كده؟ تمنتاشر و هذي؟ تلاتة و
+
+386
+00:33:28,360 --> 00:33:34,100
+تلاتين يعني سهل مش صعب كده اش بطلع؟ سبعمية في اي
+
+387
+00:33:34,100 --> 00:33:36,380
+سؤال او سفسار؟ اي سؤال؟
+
diff --git a/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/pPiKBveCB1A_postprocess.srt b/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/pPiKBveCB1A_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..e0e424c7b0f8e8da56b50d2d9a02fdff80641e49
--- /dev/null
+++ b/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/pPiKBveCB1A_postprocess.srt
@@ -0,0 +1,1388 @@
+1
+00:00:20,750 --> 00:00:23,270
+عوضوا بالله السميع العليه من الشيطان الرجيم بسم
+
+2
+00:00:23,270 --> 00:00:26,610
+الله الرحمن الرحيم الحمد لله والصلاة والسلام على
+
+3
+00:00:26,610 --> 00:00:30,650
+مصطفى الأمين سيدنا محمد وعلى آله ومن ساره على دبي
+
+4
+00:00:30,650 --> 00:00:33,870
+حساب الدين في البداية السلام عليكم ورحمة الله كيف
+
+5
+00:00:33,870 --> 00:00:37,330
+حالكوا؟ كيف أصبحتوا اليوم كويسين ان شاء الله؟ ان
+
+6
+00:00:37,330 --> 00:00:40,930
+شاء الله ما زلنا في الموازنات التشغيلية هناخد
+
+7
+00:00:40,930 --> 00:00:43,430
+اليوم مع بعض ان شاء الله الموازنة رقم 4 اللي هي
+
+8
+00:00:43,430 --> 00:00:47,410
+موازنة المواد الأولية من يذكرنا بالموازنات التلاتة
+
+9
+00:00:47,410 --> 00:00:52,550
+اللي أخدناهم قبل هيك؟موازنة المبيعات، موازنة
+
+10
+00:00:52,550 --> 00:00:55,910
+المخزون السلعي، موازنة الانتاج واليوم المواد
+
+11
+00:00:55,910 --> 00:00:59,730
+الأولية المقصود بالمواد الأولية هي المواد الخام،
+
+12
+00:00:59,730 --> 00:01:02,950
+اللي هي المواد الاش الخام، الأهم مثلا إحنا نصنع
+
+13
+00:01:02,950 --> 00:01:06,430
+جلم زي هذا، جداش عايزينه plastic، جداش عايزينه
+
+14
+00:01:06,430 --> 00:01:09,790
+حبب، عشان يصير عنا جلم أسود بهذا الشكل، هذا اللي
+
+15
+00:01:09,790 --> 00:01:12,990
+بسميه موازنة المواد الاش الأولية، تفضل يا هودة
+
+16
+00:01:12,990 --> 00:01:17,780
+الشوة إيش أهمية موازنة المواد الأولية؟توضح المواد
+
+17
+00:01:17,780 --> 00:01:20,340
+الأولية الاحتياجات المطلوبة للوفاء بالبرنامج
+
+18
+00:01:20,340 --> 00:01:23,200
+الإنتاج من كل مادة من المواد الأولية يعني أنا لو
+
+19
+00:01:23,200 --> 00:01:28,640
+بدي أعمل 9000 جلم جداش محتاجين مادة خام حباب مثلا
+
+20
+00:01:28,640 --> 00:01:34,740
+تفضلي تحدد المواد الأولية حسبأه حط خط تحتها دي،
+
+21
+00:01:34,740 --> 00:01:38,020
+المواد الأولية تحدد حسب موازنة الإنتاج وليس
+
+22
+00:01:38,020 --> 00:01:41,920
+المبيعات، إذا المواد الأولية لازم يكون عندي إنتاج،
+
+23
+00:01:41,920 --> 00:01:45,840
+عندي بعملها، ماعنديش مينفعش و الدراسات الفنية
+
+24
+00:01:45,840 --> 00:01:48,780
+والهندسية لمعدة استخدام المواد الأولية المختلفة في
+
+25
+00:01:48,780 --> 00:01:52,340
+العملية الإنتاجية تلاتة من الممكن الاحتماد على
+
+26
+00:01:52,340 --> 00:01:57,940
+التكاليف الميارية لتحديدإذاً أول حاجة بنحدد موازنة
+
+27
+00:01:57,940 --> 00:02:01,960
+المواد الأولية بالكلو و رام بالليتر بالطن حسب إيش
+
+28
+00:02:01,960 --> 00:02:05,060
+المادة الأولية بتاعة المصنع، بعدين بنجيب جداش
+
+29
+00:02:05,060 --> 00:02:08,980
+بتكلفني، يعني طن الواحد مثلا من اللطحين جداش
+
+30
+00:02:08,980 --> 00:02:12,820
+بكلفنا في إحدى المخازن، إذاً عندنا نوعين، موازن
+
+31
+00:02:12,820 --> 00:02:17,870
+مواد أوليةبالكل غرام موازنة مواد أولية بالدولار
+
+32
+00:02:17,870 --> 00:02:21,710
+اللي هي كمية شرائها يا إسلام تفضلي أربعة موازنة
+
+33
+00:02:21,710 --> 00:02:24,650
+المواد الأولية هي حلقة توصل بين موازنة الإنتاج
+
+34
+00:02:24,650 --> 00:02:27,950
+وموازنة المشتريات إذا عشان أعمل موازنة مواد أولية
+
+35
+00:02:27,950 --> 00:02:32,130
+لازم يكون عنده موازنة إنتاج عشان نعمل موازنة
+
+36
+00:02:32,130 --> 00:02:35,730
+مشتريات لازم يكون عندنا موازنة المواد الأولية يعني
+
+37
+00:02:35,730 --> 00:02:41,630
+بيعتمدوا على بعض زي ما هنشوف عندنا سؤال تفضلي نسمع
+
+38
+00:02:44,770 --> 00:02:50,650
+اللي احنا أخدناها المحاضرة الماضية اه
+
+39
+00:02:50,650 --> 00:02:56,230
+مادة خمسين الوحدة الواحدة بدها عشرة كيلو غرام
+
+40
+00:02:56,230 --> 00:03:00,130
+وتكلفة
+
+41
+00:03:00,130 --> 00:03:10,030
+الكيلو غرام الواحد واحد بين ست دينار مين
+
+42
+00:03:10,030 --> 00:03:16,010
+يشرح المادة صادصعد مين يشرحها؟ تفضلي قاية ان
+
+43
+00:03:16,010 --> 00:03:19,890
+الأبوها هتكون بتحقق 9 كيلو جرام من الأبوها هي راح
+
+44
+00:03:19,890 --> 00:03:23,950
+هتكلفتها للوحدة الواحدة الواحدة الواحدة الواحدة
+
+45
+00:03:23,950 --> 00:03:24,650
+الواحدة الواحدة الواحدة الواحدة الواحدة الواحدة
+
+46
+00:03:24,650 --> 00:03:24,830
+الواحدة الواحدة الواحدة الواحدة الواحدة الواحدة
+
+47
+00:03:24,830 --> 00:03:24,970
+الواحدة الواحدة الواحدة الواحدة الواحدة الواحدة
+
+48
+00:03:24,970 --> 00:03:25,890
+الواحدة الواحدة الواحدة الواحدة الواحدة الواحدة
+
+49
+00:03:25,890 --> 00:03:30,250
+الواحدة الواحدة الواحدة الواحدة الواحدة الواحدة
+
+50
+00:03:30,250 --> 00:03:38,050
+الواحدة الواحدة
+
+51
+00:03:38,050 --> 00:03:41,770
+الواحد
+
+52
+00:03:42,870 --> 00:03:45,750
+بنقل على عمودين هدولة بجيب موازنة المواد الأولية
+
+53
+00:03:45,750 --> 00:03:50,130
+بالكيلو ورا بعدين انتقل في الميارية، عفوا انتقل في
+
+54
+00:03:50,130 --> 00:03:52,270
+الميارية بنجيب موازنة المواد الخامة بالإيش،
+
+55
+00:03:52,270 --> 00:03:56,550
+بالدولار نون عنها كام فترة كانت؟ أربعة أربعة
+
+56
+00:03:56,550 --> 00:04:03,210
+أعطيني موازنة الإنتاج يا عيال العواضي؟ 9000 في حدا
+
+57
+00:04:03,210 --> 00:04:06,050
+بيسأل نفسي من أين بيجيبولي الأرقام؟ 15500
+
+58
+00:04:11,200 --> 00:04:16,620
+16000 فقط عالية شكرا جيبناها المحاضرة الماضية شكرا
+
+59
+00:04:16,620 --> 00:04:19,920
+يا عزيزي ولا أهللوا المادة الـ C انجدشوا كمية
+
+60
+00:04:19,920 --> 00:04:30,580
+معينية منها كيف
+
+61
+00:04:30,580 --> 00:04:33,900
+هنجيب موازنة المواد الأولية بالكيلوغрам؟ هنضرب
+
+62
+00:04:33,900 --> 00:04:36,800
+هديل الصفر 9010
+
+63
+00:04:40,090 --> 00:04:44,330
+كيلو غرام، إذا ان تسعتلاف قطعة بدها مني تسعين ألف
+
+64
+00:04:44,330 --> 00:04:57,570
+كيلو غرام، خمستاشر ألف و خمسمية، كيلو غرام، إذا
+
+65
+00:04:57,570 --> 00:05:01,370
+إنك اتحولناها باللون الأحمر من وحدات لقاش لكيلو
+
+66
+00:05:01,370 --> 00:05:05,530
+غرام، شكرا يا عزيزي، الكيلو غرام من واحد جداش سعر،
+
+67
+00:05:05,530 --> 00:05:06,690
+تفضلي سمحي بول بول؟
+
+68
+00:05:10,350 --> 00:05:21,150
+لأن كل غضب عام 1.6 موازن
+
+69
+00:05:21,150 --> 00:05:29,010
+مواد الأولية بالدولار اه يا أحلام 90 ألف و 1.6 جيش
+
+70
+00:05:29,010 --> 00:05:37,230
+بعتين اه 144 ألف أيوة دولار
+
+71
+00:05:37,230 --> 00:05:46,360
+تلت سفر اهطب هدى؟ دولار
+
+72
+00:05:46,360 --> 00:06:00,700
+ولا واحدة؟ دولار طب هدى؟ هدى؟
+
+73
+00:06:00,700 --> 00:06:10,030
+واضحة ولا عيدها؟ بدنا نشرحها إذا هناإذا بدنا نعمل
+
+74
+00:06:10,030 --> 00:06:17,830
+9000 قطع
+
+75
+00:06:17,830 --> 00:06:25,350
+من الكيك بحتاج 99000 كغ من الطحين بسعر 144 ألف
+
+76
+00:06:25,350 --> 00:06:31,770
+دولار إذا انها لعب العال، لو ننتج 11700 قطعة كيك،
+
+77
+00:06:31,770 --> 00:06:40,950
+كم بدنا 1 كغ طحين؟قداش سعرهم؟ مية سبعة و تمانين و
+
+78
+00:06:40,950 --> 00:06:45,130
+متين واضحة ولا نعيدها؟ من يطلع يعمل مادة صاد؟
+
+79
+00:06:45,130 --> 00:06:51,230
+تفضلي كفاية كل
+
+80
+00:06:51,230 --> 00:06:54,450
+طالبة تحاول تسوي مادة صاد عندها فيه كشخونة لو
+
+81
+00:06:54,450 --> 00:06:55,210
+سمحتوا؟
+
+82
+00:07:02,720 --> 00:07:16,860
+24000 او 248000 248000 بس
+
+83
+00:07:16,860 --> 00:07:19,460
+امسح الشغلات اللي اتغيرت
+
+84
+00:07:34,120 --> 00:07:37,920
+أول حزن الكمية المعيارية كتير ايها دستيريا تسعة
+
+85
+00:07:37,920 --> 00:07:41,560
+عامة لان نقول موازنة المواد الأولية المادة صاد
+
+86
+00:07:41,560 --> 00:07:50,680
+الكمية المعيارية تسعة هنقول
+
+87
+00:07:50,680 --> 00:07:55,160
+تسعة، تسعة، تسعة، تسعة، تسعة، تسعة، تسعة، تسعة،
+
+88
+00:07:55,160 --> 00:07:57,380
+تسعة، تسعة، تسعة،
+
+89
+00:08:12,110 --> 00:08:17,310
+عطوه للقابل لو سمحتوا مية و تسعة و تلاتين ألف و
+
+90
+00:08:17,310 --> 00:08:21,090
+خمسمية مية و تسعة و تلاتين ألف و خمسمية مية و خمسة
+
+91
+00:08:21,090 --> 00:08:26,630
+و تلاتمية مية و خمسة و تلاتين ألف تلاتمية تلاتمية
+
+92
+00:08:26,630 --> 00:08:34,510
+لأ مية و خمسة point تلاتمية لأ لأ البعدها قد صح قد
+
+93
+00:08:34,510 --> 00:08:37,190
+صح مية و خمسة لأ يا ..
+
+94
+00:08:52,100 --> 00:08:57,980
+مش مش مشكلة
+
+95
+00:08:57,980 --> 00:09:04,180
+خلصنا الموازنان كفاية و لا ضايق النونا ضايق الحاجة
+
+96
+00:09:04,180 --> 00:09:04,780
+اللي هي ash
+
+97
+00:09:08,690 --> 00:09:20,910
+واحد و نص واحد و نص اضغط بولها لو سمحتوا طلع
+
+98
+00:09:20,910 --> 00:09:23,650
+نفس الألقام لازم أجيبكوا .. شوفوا لازم أجيبكوا نفس
+
+99
+00:09:23,650 --> 00:09:29,810
+الألقام انت مش نفس الألقام انا هعمل حاجة غلط مائة
+
+100
+00:09:29,810 --> 00:09:36,370
+و سبعة و خمسين مائة و سبعة و خمسين
+
+101
+00:09:48,710 --> 00:09:57,130
+221.400 شكرني
+
+102
+00:09:57,130 --> 00:10:02,090
+كفاية في أي حاجة غامضة في الحال كفاية؟ في أي حاجة
+
+103
+00:10:02,090 --> 00:10:09,750
+مش واضحة؟ في أي حاجة مش واضحة؟ ال sheet لو سمحتوا؟
+
+104
+00:10:09,750 --> 00:10:13,250
+في
+
+105
+00:10:13,250 --> 00:10:22,820
+حد ناسي ال sheetال sheet لو سمحتوا لنسية ولا شغلة
+
+106
+00:10:22,820 --> 00:10:33,980
+ممكن تاخد من هنا تفضلي يا عزيزي
+
+107
+00:10:33,980 --> 00:10:37,800
+في حاجة اسمها .. تفضلي
+
+108
+00:10:41,770 --> 00:10:45,230
+السؤال كان عندنا واحد لإتنين بالدولار و تلاتة أو
+
+109
+00:10:45,230 --> 00:10:50,270
+أربعة كيلو وراه لأ خطأ مطبعي بيكون خطأ هذا بيكون
+
+110
+00:10:50,270 --> 00:10:55,230
+هو كله دولار كله إيش دولار يالا يا دلال اقرأينا
+
+111
+00:10:55,230 --> 00:11:06,510
+السؤال الأول في ال sheet لو سمحت تنتج
+
+112
+00:11:06,510 --> 00:11:07,890
+أحد الشركات الصناعية
+
+113
+00:11:11,660 --> 00:11:15,720
+أحد الشركات الصناعية ألمان ترسيس وتبيع الوحدة منه
+
+114
+00:11:15,720 --> 00:11:20,400
+بسعر معيار يقدر 2.5 دينار وتخطط تقوم ببيعها أربع
+
+115
+00:11:20,400 --> 00:11:25,860
+سنوية لعام 2009 التالف 40 ألف وحدة، 60 ألف وحدة،
+
+116
+00:11:25,860 --> 00:11:33,720
+665 ألف عفوان وحدة، 36 ألف وحدة على التواريف
+
+117
+00:11:33,720 --> 00:11:37,080
+ويحتاج إنتاج وحدة ألمانية لأجهزة الأولياء هاي
+
+118
+00:11:37,080 --> 00:11:42,460
+موضوعنا اليوميحتاج إنتاج وحدة المونتاج إلى مواد
+
+119
+00:11:42,460 --> 00:11:47,500
+الأولية صار بستة من عشرة كيلو جرام بسعة سعت سعت
+
+120
+00:11:47,500 --> 00:11:48,080
+سعت سعت سعت سعت سعت سعت سعت سعت سعت سعت سعت سعت
+
+121
+00:11:48,080 --> 00:11:48,740
+سعت سعت سعت سعت سعت سعت سعت سعت سعت سعت سعت سعت
+
+122
+00:11:48,740 --> 00:11:50,700
+سعت سعت سعت سعت سعت سعت سعت سعت سعت سعت سعت سعت
+
+123
+00:11:50,700 --> 00:11:51,340
+سعت سعت سعت سعت سعت سعت سعت سعت سعت سعت سعت سعت
+
+124
+00:11:51,340 --> 00:12:05,780
+سعت سعت سعت سعت سعت سعت سعت سعت سعت سعت سعت سعت
+
+125
+00:12:08,310 --> 00:12:11,150
+مين يعطينا أرقام موازنة الإنتاج جيبناها مع بعض
+
+126
+00:12:11,150 --> 00:12:14,850
+المرة الماضية؟ يلا يا أه يا سيد، بس توصل لزمنك
+
+127
+00:12:14,850 --> 00:12:24,430
+لحظة، الآن أه يا سيد هتساعدك، هتعطيكي أرقام موازنة
+
+128
+00:12:24,430 --> 00:12:25,750
+الإنتاج المحاضرة الماضية
+
+129
+00:12:38,070 --> 00:12:44,770
+هو نفس الجدول بس احنا نمسح الأرقام بس
+
+130
+00:12:44,770 --> 00:12:48,810
+كان عندنا ايش؟ واحد، اتنين، تلاتة، اربعة، واحد،
+
+131
+00:12:48,810 --> 00:12:54,770
+اتنين، فنون، فنون،
+
+132
+00:12:54,770 --> 00:12:58,170
+واحد، اتنين، تلاتة، اربعة، واحد، اتنين، يلا يا أيا
+
+133
+00:12:58,170 --> 00:12:58,550
+سعيد
+
+134
+00:13:02,340 --> 00:13:06,580
+وحدة ولا دولار ولا مين؟ لأ ممتاز كان عندنا يا غدية
+
+135
+00:13:06,580 --> 00:13:10,860
+بتسعة واربعين ألف وحدة وواحدة ستين ألف وواحدة ستين
+
+136
+00:13:10,860 --> 00:13:16,420
+ألف ومتان وخمسين ومتان وخمسين؟ في حد بيسأل نفسه من
+
+137
+00:13:16,420 --> 00:13:18,980
+أمه جيب لقاه؟ ومتان وخمسين ألف .. هذا حل السؤال
+
+138
+00:13:18,980 --> 00:13:22,800
+الماضي في ال sheet لأ لأ يا .. وواحدة ستين ألف
+
+139
+00:13:22,800 --> 00:13:27,740
+ومتان وخمسين ومتان وخمسين لأ .. لأ لأ يا .. وواحدة
+
+140
+00:13:27,740 --> 00:13:30,120
+ستين ألف ومتان وخمسين ومتان وخمسين ومتان وخمسين
+
+141
+00:13:30,120 --> 00:13:32,560
+ومتان وخمسين ومتان وخمسين ومتان وخمسالأول واحدة
+
+142
+00:13:32,560 --> 00:13:36,200
+تسعة و أربعين ألف، تمام؟ بعدين واحدة و ستين ألف و
+
+143
+00:13:36,200 --> 00:13:41,560
+متين و خمسين، بعدين
+
+144
+00:13:41,560 --> 00:13:46,840
+سبعة و خمسين ألف و سبعمية و خمسين، بعدين تمانية و
+
+145
+00:13:46,840 --> 00:13:52,940
+تلاتين، سبعة و خمسين ألف و سبعمية و خمسين، تمانية
+
+146
+00:13:52,940 --> 00:13:59,920
+و تلاتين ألف، بعدين خمسة و أربعين ألف، لأ لأ،
+
+147
+00:13:59,920 --> 00:14:07,040
+تمانية و أربعين ألف لحال،خمسة قعدتنا سنة خمسين
+
+148
+00:14:07,040 --> 00:14:13,280
+تلاتين قعدتنا خمسة أربعين كداش
+
+149
+00:14:13,280 --> 00:14:16,200
+الكمية المعينة في السؤال قبصة؟ ستة من عشرة أي
+
+150
+00:14:16,200 --> 00:14:23,860
+أسماء؟ ستة؟ أه، ستة من عشرة، مش ستة من ستة من عشرة
+
+151
+00:14:23,860 --> 00:14:31,300
+يعني ستة من عشرة يعني ستة من عشرة يعني
+
+152
+00:14:43,440 --> 00:14:49,040
+ممتاز اعطوها الناتج لو سمحتوا دي انخزن ده ممكن
+
+153
+00:14:49,040 --> 00:14:55,420
+تعطيها الناتج يا انتي احسبوه
+
+154
+00:14:55,420 --> 00:15:06,460
+لو اعطوها الناتج 29400 36750
+
+155
+00:15:10,290 --> 00:15:16,470
+أربعة و تلاتين ألف و ستمائة و خمسين أربعة
+
+156
+00:15:16,470 --> 00:15:18,350
+و تلاتين ألف و ستمائة و خمسين أربعة و تلاتين ألف و
+
+157
+00:15:18,350 --> 00:15:25,090
+تمانية أربعة و تلاتين ألف و تمانية أربعة و تلاتين
+
+158
+00:15:25,090 --> 00:15:25,990
+ألف و تمانية أربعة و تلاتين ألف و تمانية أربعة و
+
+159
+00:15:25,990 --> 00:15:26,130
+تلاتين ألف و تمانية أربعة و تلاتين ألف و تمانية
+
+160
+00:15:26,130 --> 00:15:28,230
+أربعة و تمانية أربعة و تمانية أربعة و تمانية أربعة
+
+161
+00:15:28,230 --> 00:15:30,490
+و تمانية أربعة و تمانية أربعة و تمانية أربعة و
+
+162
+00:15:30,490 --> 00:15:30,810
+تمانية أربعة و تمانية أربعة و تمانية أربعة و
+
+163
+00:15:30,810 --> 00:15:38,570
+تمانية أربعة و
+
+164
+00:15:38,570 --> 00:15:39,090
+تمانية أرب
+
+165
+00:15:48,100 --> 00:15:52,500
+كتاباتها ده صح ولا بيبقى مشاكل؟ ده صح احسبوله لو
+
+166
+00:15:52,500 --> 00:15:58,220
+سمحتوا احسبيه ليا هال عبدالعالم كبيرة دلوقتي
+
+167
+00:15:58,220 --> 00:16:01,780
+اكبرهاش
+
+168
+00:16:01,780 --> 00:16:02,620
+سمحتك هم
+
+169
+00:16:10,730 --> 00:16:13,090
+26 دولار و 460 دولار تقعد من واحد اتنين تقعد من
+
+170
+00:16:13,090 --> 00:16:14,510
+واحد اتنين تقعد من واحد اتنين تقعد من واحد اتنين
+
+171
+00:16:14,510 --> 00:16:15,550
+تقعد من واحد اتنين تقعد من واحد اتنين تقعد من واحد
+
+172
+00:16:15,550 --> 00:16:15,870
+اتنين تقعد من واحد اتنين تقعد من واحد اتنين تقعد
+
+173
+00:16:15,870 --> 00:16:17,710
+من واحد اتنين تقعد من واحد اتنين تقعد من واحد
+
+174
+00:16:17,710 --> 00:16:19,670
+اتنين تقعد من واحد اتنين تقعد من واحد اتنين تقعد
+
+175
+00:16:19,670 --> 00:16:19,790
+من واحد اتنين تقعد من واحد اتنين تقعد من واحد
+
+176
+00:16:19,790 --> 00:16:24,470
+اتنين تقعد من واحد اتنين تقعد من واحد اتنين تقعد
+
+177
+00:16:24,470 --> 00:16:36,770
+من واحد اتنين تقعد من واحد اتنين تقعد من
+
+178
+00:16:39,520 --> 00:16:43,240
+أه عشان هيك إذا مش فاهم ده خلاص ممكنش أجيبها ممتاز
+
+179
+00:16:43,240 --> 00:16:47,440
+تلاتة تلاتة سفر سبعة خمسة لأ سفر إن كان الإنتاج
+
+180
+00:16:47,440 --> 00:16:50,400
+نفس الشغل مافيش إنتاج خاص بشليها يعني مضايق حالك
+
+181
+00:16:50,400 --> 00:17:01,520
+واحد و تلاتين ألف مية خمسة و تمانين عشرين
+
+182
+00:17:01,520 --> 00:17:02,860
+ألف و خمسمية و عشرين
+
+183
+00:17:17,070 --> 00:17:20,470
+شكرا يا دلال، بارك الله فيك، شكرا يا عزيزي واضحة
+
+184
+00:17:20,470 --> 00:17:29,510
+موازنة مواد الأولية و لا عيدها؟ عيد و شرح تاني عيد
+
+185
+00:17:29,510 --> 00:17:33,950
+و شرح تاني؟ لازم نفهم الأرقام، ها دي إيش و ها دي
+
+186
+00:17:33,950 --> 00:17:39,550
+إيش اسلام، ابو سيدو، ما المقصود موازنة مواد
+
+187
+00:17:39,550 --> 00:17:41,710
+الأولية بالكيلو غرام اللي عملتها دلال حجاج؟
+
+188
+00:17:54,630 --> 00:17:57,310
+مالك يا عزيزي، أنا بسالك على الصبورة، السؤال،
+
+189
+00:17:57,310 --> 00:18:03,150
+خلصنا هذا احنا ايوة، إيش يعني، إيش يعني الأرقام؟
+
+190
+00:18:03,150 --> 00:18:09,450
+موازنة المواد الأولية بالكيلوغرام، إيش معناها؟ شهر
+
+191
+00:18:09,450 --> 00:18:13,890
+واحد، جداش موازنة الإنتاج مكتوب؟ تسعة واربعين ألف
+
+192
+00:18:13,890 --> 00:18:17,350
+تسعة واربعين ألف، إيش؟ واحدة جداش بنقلهم
+
+193
+00:18:17,350 --> 00:18:18,230
+بالكيلوغرام؟
+
+194
+00:18:20,770 --> 00:18:29,610
+كلغة؟ ممتاز، جداش هيكلفوني هدول؟ 96 جداش
+
+195
+00:18:29,610 --> 00:18:36,750
+أسلم؟ أيوة؟ ممتاز، شكرا يا عزيزي عيدها تاني؟
+
+196
+00:18:36,750 --> 00:18:42,970
+عيدها؟ نورال ماني المواد الأولية أو جداش ننتج لشهر
+
+197
+00:18:42,970 --> 00:18:48,230
+تلاتة؟ لشهر تلاتة، جداش هننتج؟
+
+198
+00:18:52,240 --> 00:19:00,960
+34 ألف، كدهش محتاج مواد خام؟ 135 .. 135 .. 135 ..
+
+199
+00:19:00,960 --> 00:19:03,480
+135 .. 135 .. 135 .. 135 .. 135 .. 135 .. 135 ..
+
+200
+00:19:03,480 --> 00:19:07,580
+135 .. 135 .. 135 .. 135 .. 135 .. 135 .. 135 ..
+
+201
+00:19:07,580 --> 00:19:08,260
+135 .. 135 .. 135 .. 135 .. 135 .. 135 .. 135 ..
+
+202
+00:19:08,260 --> 00:19:08,760
+135 .. 135 .. 135 .. 135 .. 135 .. 135 .. 135 ..
+
+203
+00:19:08,760 --> 00:19:08,840
+135. 135. 135. 135. 135. 135. 135. 135. 135. 135.
+
+204
+00:19:08,840 --> 00:19:10,660
+135. 135. 135. 135. 135. 135.
+
+205
+00:19:17,280 --> 00:19:22,290
+135تسعين ألف بتحبوا تساعدوا بعضك دول لازم نرقمها و
+
+206
+00:19:22,290 --> 00:19:24,630
+نفهمها هي إيش، مش نكتب أرقام و نضغط و نضلنا ماشية،
+
+207
+00:19:24,630 --> 00:19:28,950
+لازم نفهمها ده الشيء شكرا يا نوران أخر حاجة اليوم
+
+208
+00:19:28,950 --> 00:19:35,030
+موازنة المشتريات من المواد الأولية تفضلي
+
+209
+00:19:35,030 --> 00:19:40,490
+دي نحو زندان، اقرأينا يا وانتي إيش مكتوب؟
+
+210
+00:19:44,610 --> 00:19:47,930
+طبعاً، على طول، بس نتكلم عن كميات، معناها نتكلم عن
+
+211
+00:19:47,930 --> 00:19:49,210
+حاجة ممكن نخزّنها.
+
+212
+00:19:52,190 --> 00:19:56,890
+أه؟ إذن كان يجب أن يكون عادي مواد إذا فيه سياسة
+
+213
+00:19:56,890 --> 00:20:02,610
+تخزين أو لا؟ إذن، بدل فيه مواد أولية، إذا فيه
+
+214
+00:20:02,610 --> 00:20:05,390
+تخزين، إذا فيه سياسة تخزين، تفضّالي. تاني
+
+215
+00:20:05,390 --> 00:20:09,250
+الكمبيوتر يتعامل الأقتصاد ويتعامل الشراء، وبالتالي
+
+216
+00:20:09,250 --> 00:20:13,170
+تحكي المواعيد الشراء، وتحصور عن الكمية المباقرة من
+
+217
+00:20:13,170 --> 00:20:17,140
+المواد الأولية؟طب بنعدى بالساعدنى على تحديد مواعيد
+
+218
+00:20:17,140 --> 00:20:19,520
+الشراء، تحديد الكيميا الاقتصادية الملاعبة، تحديد
+
+219
+00:20:19,520 --> 00:20:22,700
+المخصوصات الأولية، تكلفات المواد الأولية وها كده،
+
+220
+00:20:22,700 --> 00:20:26,280
+تفضل اتنين تفضل اتنين توضح خطة شراء احتياجاتنا
+
+221
+00:20:26,280 --> 00:20:30,140
+المطلوبة لمجموعة التكنولوجيا الأولية لإنسان مختلف
+
+222
+00:20:30,140 --> 00:20:34,600
+من الثانوية لإنها بتوضح خطة الشراء لاحتياجاتنا
+
+223
+00:20:34,600 --> 00:20:37,660
+المطلوبة قبل شوية كانوا هنا في السؤال الأولاني سين
+
+224
+00:20:37,660 --> 00:20:41,160
+و ساد، هل هنروح نشتري سين و ساد مع بعض، سين و
+
+225
+00:20:41,160 --> 00:20:43,700
+بعدين ساد، لأ ساد و بعدين سين، هذا المقصد
+
+226
+00:20:47,690 --> 00:20:52,510
+أه حطوا تحتها خط علشان نعمل مشتريات إيش لازم يكون
+
+227
+00:20:52,510 --> 00:20:56,250
+عندي؟ مواد أولي جامشوري حكينا إن موازنة مواد أولي
+
+228
+00:20:56,250 --> 00:21:04,810
+حلقة تواصل بين الإنتاج والمشتريات تفضلي
+
+229
+00:21:04,810 --> 00:21:11,990
+أيوة أنا أدور المفروض بفائض .. بفائض أداء إيزاني
+
+230
+00:21:11,990 --> 00:21:18,490
+.. إيزاني الشراكة في أجهزةالشركات الحاضرة مع لجنة
+
+231
+00:21:18,490 --> 00:21:22,230
+الأداء المحطمة التسليزيائية تفاقد هذه الإدارة تفضل
+
+232
+00:21:22,230 --> 00:21:26,770
+إيجارات الإنتاج في مواهب المستخدمين بها وإدارة
+
+233
+00:21:26,770 --> 00:21:31,250
+الشراء. إذن، أيوة، تعتبر موازمة المشتريات هي أحد
+
+234
+00:21:31,250 --> 00:21:35,310
+أدوات الرقابة المستخدمة للرقابة على أدائش على
+
+235
+00:21:35,310 --> 00:21:40,230
+إدارة الشراء. تفضلي. مشروع التوليد المناسب للشركة
+
+236
+00:21:40,230 --> 00:21:47,310
+بدأ يتطلع علىشكرا يا انتي لو طلقنا القانون مواظة
+
+237
+00:21:47,310 --> 00:21:51,310
+علينا قبل هيك هذا انا شوفته قبل هيك انت شوفته؟
+
+238
+00:21:51,310 --> 00:21:59,250
+موازة من .. بتشبه موازة من؟ ال .. الانتاج مخزون
+
+239
+00:21:59,250 --> 00:22:02,390
+السلعي نسبالي يا انتي عموما كان زي هيك اللي جمعنا
+
+240
+00:22:02,390 --> 00:22:06,290
+منه مخزون أخر مدة طرحنا منه أول مدة من كان؟ موازة
+
+241
+00:22:06,290 --> 00:22:10,910
+الانتاج موازة الانتاج ايش؟ الانتاج عندنا سؤال
+
+242
+00:22:10,910 --> 00:22:15,030
+قرأينا يا نسمةباعتماد على بيانات السؤال الصحيح
+
+243
+00:22:15,030 --> 00:22:19,090
+سواء من المشتريات إذا عرفتي أقل مقدومة أقل مقدومة
+
+244
+00:22:19,090 --> 00:22:23,370
+من المواد الأولية 25% من اجتماع المصادر وسائل شراء
+
+245
+00:22:23,370 --> 00:22:30,570
+المواد الأولية هو 2 دينار كل kilogram و 1 دينار كل
+
+246
+00:22:30,570 --> 00:22:34,310
+kilogram على الدوار اللي كانت أول مدة تانه الفرق
+
+247
+00:22:34,310 --> 00:22:41,820
+بين 100 kilogram و 3000 kilogram شكري أنتيأنا
+
+248
+00:22:41,820 --> 00:22:49,580
+خلتها علشان أخده الأرقام إذا موازنة مشتريات
+
+249
+00:22:49,580 --> 00:22:54,980
+المدسين هاي
+
+250
+00:22:54,980 --> 00:23:03,660
+القانون بدنا نون موجودة في السؤال هذا الشيط؟ أه لأ
+
+251
+00:23:03,660 --> 00:23:09,060
+أنا بدأ أولا يعني أه أه ماشي خلاص رجعته شكرا يا
+
+252
+00:23:09,060 --> 00:23:16,790
+سمهنإيش هنكتب القانون؟ هنقول موازنة المادة الأولية
+
+253
+00:23:16,790 --> 00:23:21,310
+سين بالكيلو غرام خودي بالك لإن انت عندي كانت انت
+
+254
+00:23:21,310 --> 00:23:24,130
+واحدة دولار و واحدة كيلو غرام مين هجيب الكيلو
+
+255
+00:23:24,130 --> 00:23:34,290
+غرام؟ بعدين مخزون أخر المدة مخزون مواد أولية أخر
+
+256
+00:23:34,290 --> 00:23:43,750
+المدة بعدين مخزون مواد أوليةأول مدة بطلع عندنا
+
+257
+00:23:43,750 --> 00:23:53,750
+الحل موازنة المشتريات احنا موازنة المادة الأولية
+
+258
+00:23:53,750 --> 00:24:00,570
+سين بالكيلوغрам في حد بيقول من أين جابوها؟ 155 ألف
+
+259
+00:24:00,570 --> 00:24:05,010
+117
+
+260
+00:24:05,010 --> 00:24:09,850
+ألف 164 ألف كيلوغرام
+
+261
+00:24:11,610 --> 00:24:18,070
+مثلا عند اتنين مية و خمسة و خمسين، عند اتنين مية و
+
+262
+00:24:18,070 --> 00:24:25,610
+خمسة و خمسين شكرا يا أسمع، كدهش مخزون أخر مدة يهيأ
+
+263
+00:24:25,610 --> 00:24:33,590
+سعيد في السؤال؟ هو
+
+264
+00:24:33,590 --> 00:24:35,350
+السؤال اللي قلتها ..
+
+265
+00:24:38,320 --> 00:24:41,420
+البرمجة أو الـ 25%؟ لأ خلاص، احنا بنكتب الأرقام
+
+266
+00:24:41,420 --> 00:24:44,780
+نشغلها طيب، هيك بناخد لبعض السؤال اللي فات، ناخد
+
+267
+00:24:44,780 --> 00:24:47,840
+أخر البرمجة اللي فات إيش أخد السؤال اللي فات في
+
+268
+00:24:47,840 --> 00:24:53,260
+الموضوع؟ اقل السؤال يعني باعتماد؟
+
+269
+00:24:53,260 --> 00:24:55,940
+الـ 25% قبل ما تردت، عامة الميارة، هل تقعدت
+
+270
+00:24:55,940 --> 00:24:58,100
+سابقًا؟ قد قدت موازنة مشتركة، ده عامة؟ أنا مخصوة
+
+271
+00:24:58,100 --> 00:25:02,600
+من أخر المرة، يعني الـ 25% يعني الـ 25% ضارب الـ 9
+
+272
+00:25:02,600 --> 00:25:03,480
+أيوة
+
+273
+00:25:06,460 --> 00:25:10,120
+كداش ثمانية وتسعين ألف يا أخوات؟ ألفين و أربعين و
+
+274
+00:25:10,120 --> 00:25:11,200
+خمسمية .. اتنين و اتنين و أتنين و أتنين و أتنين و
+
+275
+00:25:11,200 --> 00:25:15,960
+أتنين و أتنين و أتنين و أتنين و أتنين و أتنين و
+
+276
+00:25:15,960 --> 00:25:20,500
+أتنين و أتنين و أتنين و أتنين و أتنين و أتنين و
+
+277
+00:25:20,500 --> 00:25:20,720
+أتنين و أتنين و أتنين و أتنين و أتنين و أتنين و
+
+278
+00:25:20,720 --> 00:25:20,840
+أتنين و أتنين و أتنين و أتنين و أتنين و أتنين و
+
+279
+00:25:20,840 --> 00:25:24,700
+أتنين و أتنين و أتنين و أتنين و أتنين و أتنين و
+
+280
+00:25:24,700 --> 00:25:35,120
+أتنين و أتنين و أتنين و أ
+
+281
+00:25:37,480 --> 00:25:43,120
+مين هذا مخزون أخر المدة؟ واضح هي آية ولا منيدها؟
+
+282
+00:25:43,120 --> 00:25:46,260
+اه لا واضح ماشي ان شاء الله و لا هلال و مخزون أول
+
+283
+00:25:46,260 --> 00:25:50,140
+المدة؟ مُعطَف السؤال و لا من وين جبتي الرقم؟
+
+284
+00:25:50,140 --> 00:25:52,260
+مُعطَف، مُعطَف، مُعطَف، مُعطَف، مُعطَف، مُعطَف،
+
+285
+00:25:52,260 --> 00:25:54,840
+مُعطَف، مُعطَف، مُعطَف، مُعطَف، مُعطَف، مُعطَف،
+
+286
+00:25:54,840 --> 00:25:56,360
+مُعطَف، مُعطَف، مُعطَف، مُعطَف، مُعطَف، مُعطَف،
+
+287
+00:25:56,360 --> 00:26:01,980
+مُعطَف، مُعطَف،
+
+288
+00:26:01,980 --> 00:26:05,280
+مُعطَف،
+
+289
+00:26:05,280 --> 00:26:07,220
+مُعطَ
+
+290
+00:26:09,880 --> 00:26:14,240
+خد الشوة كيف هنعمل معادلة؟ موازنة المشتريات؟ أه
+
+291
+00:26:14,240 --> 00:26:22,760
+كيف هنجيبها؟ تسعين ألف زائد أخر المدة نقص ناقص
+
+292
+00:26:22,760 --> 00:26:30,040
+ألفين وخمسمية الناتج لو سمحتوا؟ مية وعشرة ألف مية
+
+293
+00:26:30,040 --> 00:26:36,120
+وعشرة ألف مية وواحدة وسبعين مية وواحدة وسبعين ألف
+
+294
+00:26:36,120 --> 00:26:37,760
+مية وواحدة وسبعين ألف مية وواحدة وسبعين ألف
+
+295
+00:26:47,860 --> 00:26:55,100
+الأخيرة واضحة ولا نعيدها؟ نعمل صاد مينها
+
+296
+00:26:55,100 --> 00:26:57,680
+بيعمل مادة صاد؟ صاد
+
+297
+00:27:09,230 --> 00:27:18,050
+مين كمان حابب شعرك في صاد؟ يلا يا أسماء، أعطوها
+
+298
+00:27:18,050 --> 00:27:22,570
+الألقام لو سمحتوا، لإن هنقول موازنة نوات لأوليها
+
+299
+00:27:22,570 --> 00:27:26,890
+المادة مين، صاد، لازم يكون معطينا بيانات صاد
+
+300
+00:27:40,630 --> 00:27:43,290
+طب هنعدي موازنة المشتريات بالكيلو غرام خودي بالك
+
+301
+00:27:43,290 --> 00:27:46,910
+لو ضربتيها في السعر اللي هو اتنين هنجيب موازنة
+
+302
+00:27:46,910 --> 00:27:51,470
+المشتريات بالدولار إذا هنلجعينا السعر اللي ضربناها
+
+303
+00:27:51,470 --> 00:27:58,070
+فيه هنجيب موازنة المشتريات بالدولار موازنة
+
+304
+00:27:58,070 --> 00:28:08,890
+المواد الأولية لصعد 81 ألف 139500
+
+305
+00:28:13,890 --> 00:28:20,450
+ممتازة و ده؟ في حد بيسأل نفسك و يقول أمي أجيبه
+
+306
+00:28:20,450 --> 00:28:23,990
+دقام هذا؟ أه يا غديا تسأل نفسك و يقول أمي أجيبه
+
+307
+00:28:23,990 --> 00:28:28,650
+الأقام قاعدين؟ بسهلليش نفسك؟ لأنك مش معانا يعني
+
+308
+00:28:28,650 --> 00:28:35,260
+خليكي معانا لو سمحتيمفزون مواد أخر المدة الأولية
+
+309
+00:28:35,260 --> 00:28:48,140
+25% مواطنيها بالسؤال بضرب 81 ألف و 25% عشرين
+
+310
+00:28:48,140 --> 00:28:56,260
+ألف و بيتن و خمسين أربعة
+
+311
+00:28:56,260 --> 00:29:00,920
+و تلاتين ألف و تمانية و خمس و سبعين أربعة و تلاتين
+
+312
+00:29:00,920 --> 00:29:06,870
+ألفسهل الكلام هذا ولا سهل؟ سهل بس لو تتراكم فوق
+
+313
+00:29:06,870 --> 00:29:12,130
+بعضه هتلاقي أول مرة تسمع عنه هكذا هو بندرس كش ..
+
+314
+00:29:12,130 --> 00:29:18,930
+يعني ككتلة كاملة اه هو محتمال يكونوا التلاتة أو
+
+315
+00:29:18,930 --> 00:29:26,670
+الأربعة كمان يعني أو الخمسة لسه حسب
+
+316
+00:29:26,670 --> 00:29:30,370
+السؤال مخزون مواد أولية أو للمجتمع؟ مخزون مواد
+
+317
+00:29:30,370 --> 00:29:35,470
+أولية أو للمجتمع؟سؤال ال shoot، سؤال الامتحان، طلب
+
+318
+00:29:35,470 --> 00:29:50,550
+منك خمسة عشان
+
+319
+00:29:50,550 --> 00:29:51,870
+أسألي، لمّا أتراجع مايكونش نسيت
+
+320
+00:30:00,580 --> 00:30:04,780
+موازنة المشتريات هي عبارة عن موازنة المادة الأولية
+
+321
+00:30:04,780 --> 00:30:12,380
+صاد زائد أخر المدة و أقصد أول المدة هيطلع 98 ألف و
+
+322
+00:30:12,380 --> 00:30:24,860
+مدينة و خمسين 987656154155154155
+
+323
+00:30:24,860 --> 00:30:28,880
+بعدين 96715
+
+324
+00:30:33,790 --> 00:30:37,390
+السنة التاسعة ألف وسبعمائة وسبعمائة وسبعمائة
+
+325
+00:30:37,390 --> 00:30:39,070
+وسبعمائة وسبعمائة وسبعمائة وسبعمائة وسبعمائة
+
+326
+00:30:39,070 --> 00:30:41,570
+وسبعمائة وسبعمائة وسبعمائة وسبعمائة وسبعمائة
+
+327
+00:30:41,570 --> 00:30:43,230
+وسبعمائة وسبعمائة وسبعمائة وسبعمائة وسبعمائة
+
+328
+00:30:43,230 --> 00:30:44,750
+وسبعمائة وسبعمائة وسبعمائة وسبعمائة وسبعمائة
+
+329
+00:30:44,750 --> 00:30:45,410
+وسبعمائة وسبعمائة وسبعمائة وسبعمائة وسبعمائة
+
+330
+00:30:45,410 --> 00:30:47,730
+وسبعمائة وسبعمائة وسبعمائة وسبعمائة وسبعمائة
+
+331
+00:30:47,730 --> 00:30:47,770
+وسبعمائة وسبعمائة وسبعمائة وسبعمائة وسبعمائة
+
+332
+00:30:47,770 --> 00:30:49,410
+وسبعمائة وسبعمائة وسبعمائة وسبعمائة وسبعمائة
+
+333
+00:30:58,310 --> 00:31:02,250
+لو بدك تجيبليها بالدولار و تضبيها في واحد لأ مش
+
+334
+00:31:02,250 --> 00:31:06,590
+النسبة سعر الشراك لو بدك تجيب مواصلة المشتريات
+
+335
+00:31:06,590 --> 00:31:09,750
+بالدولار الكلام هذا أخر عمود هتضبيه في سعر الشراك
+
+336
+00:31:09,750 --> 00:31:18,750
+اللي هو واحد ماعطيكي واحد سؤال أخيرا مية و تمانية
+
+337
+00:31:18,750 --> 00:31:23,590
+أمس مية و خمسة و شبعين مية و تمانية و خمسة و مية و
+
+338
+00:31:23,590 --> 00:31:26,150
+خمسة و سبعين مية و تمانية و مية و خمسة و سبعين
+
+339
+00:31:27,280 --> 00:31:32,220
+احسبونا الأخير مرة تانية لو سمحتوا فيه إنا كمان
+
+340
+00:31:32,220 --> 00:31:36,880
+سؤال في ال sheet تحلولوا حالكوا في البيت؟ السؤال
+
+341
+00:31:36,880 --> 00:31:42,320
+ال sheet تحلولوا حالكوا في البيت؟ فيه أي سؤال أو
+
+342
+00:31:42,320 --> 00:31:45,840
+استفسار؟ أي سؤال في المحاضر اليوم؟ أتوقع المحاضر
+
+343
+00:31:45,840 --> 00:31:49,920
+سهل ان شاء الله ماشي
+
+344
+00:31:49,920 --> 00:31:51,520
+..ماشي ..ماشي ..ماشي ..ماشي ..ماشي ..ماشي ..ماشي
+
+345
+00:31:51,520 --> 00:31:51,720
+..ماشي ..ماشي ..ماشي ..ماشي ..ماشي ..ماشي ..ماشي
+
+346
+00:31:51,720 --> 00:31:51,760
+..ماشي ..ماشي ..ماشي ..ماشي ..ماشي ..ماشي ..ماشي
+
+347
+00:31:51,760 --> 00:31:53,060
+..ماشي ..ماشي
+
diff --git a/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/r2Lb2YuBpMA_postprocess.srt b/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/r2Lb2YuBpMA_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..902245e63027da2aa45905b80428262c5eef164f
--- /dev/null
+++ b/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/r2Lb2YuBpMA_postprocess.srt
@@ -0,0 +1,1064 @@
+1
+00:00:21,010 --> 00:00:23,290
+عودوا بالله السلام علينا الشيطان الرجيم بسم الله
+
+2
+00:00:23,290 --> 00:00:25,550
+الرحمن الرحيم الحمد لله والصلاة والسلام على
+
+3
+00:00:25,550 --> 00:00:29,510
+المصطفى الأمين سيدنا محمد وعلى ألي ومن سارة على
+
+4
+00:00:29,510 --> 00:00:31,550
+دور بيه السلام الدين فبدأ السلام عليكم يا أحمد
+
+5
+00:00:31,550 --> 00:00:36,630
+الله كيف حالكم؟ كيف أسبحتوا اليوم؟ بعد ما خلصنا
+
+6
+00:00:36,630 --> 00:00:40,010
+الموازنات التشغيلية والموازنات المارنة اليوم ان
+
+7
+00:00:40,010 --> 00:00:42,370
+شاء الله راح نبدأ بحاجة جديدة شوية مختلفة عنهم
+
+8
+00:00:42,370 --> 00:00:46,630
+اللي هي الرقابة الإدارية في ضل ألة مركزية طبعا
+
+9
+00:00:46,630 --> 00:00:52,750
+أمامنا تلت مصطلحات على الصبورةالرقابة مصطلح،
+
+10
+00:00:52,750 --> 00:00:57,550
+الإدارية مصطلح، المركزية مصطلح، مين اذا كنا شوية
+
+11
+00:00:57,550 --> 00:01:02,130
+عارف الرقابة ببساطة؟
+
+12
+00:01:02,130 --> 00:01:10,750
+تفضلي هي مجموعة ال .. بتقارن المخطط مع المغنيماشي
+
+13
+00:01:10,750 --> 00:01:15,170
+أسهل تعريف للرقابة هو التأكد من أن ما خُطط له هو
+
+14
+00:01:15,170 --> 00:01:19,770
+ما تم تنفيضه واتخاذ إجراءات إيش؟ تصحيحية، إذا
+
+15
+00:01:19,770 --> 00:01:24,550
+التأكد من أن ما خُطط له هو ما تم تنفيضه الإدارة،
+
+16
+00:01:24,550 --> 00:01:30,530
+إيش تعريف الإدارة؟ تختار تنظيم توجيه رقابة، هو
+
+17
+00:01:30,530 --> 00:01:35,190
+استغلال المواد المتاحة بحقيق الأهداف إلا مركزية
+
+18
+00:01:36,320 --> 00:01:42,460
+تفضلي ممتازة توزيء أو تشتت السلطات والمهام الإدارة
+
+19
+00:01:42,460 --> 00:01:46,440
+للإدارة الدنيا إذا نشرب تلتبعنا اليوم الرقابة
+
+20
+00:01:46,440 --> 00:01:50,160
+الإدارية في الضل اللي مركزية أعتقد التفاقت مع
+
+21
+00:01:50,160 --> 00:01:56,320
+طلبها تشرح، هتشرحي من أول slide؟ تفضلي ماشي ان شاء
+
+22
+00:01:56,320 --> 00:02:00,300
+الله نشوف مع بعض إيش كتبنا، تفضلي يا مريم
+
+23
+00:02:06,210 --> 00:02:11,390
+كل ما كانت المؤسسة بتاعة كبيرة سواء في الموظفين أو
+
+24
+00:02:11,390 --> 00:02:16,130
+في حجم العمل بيكون الرقابة صعبة شوية تفضلي لأن ذلك
+
+25
+00:02:16,130 --> 00:02:19,790
+تحتاج إدارة إلى تفويد الصلاحيات والسلطات المسلوية
+
+26
+00:02:19,790 --> 00:02:23,630
+تفويد الصلاحيات والسلطات اللي حكت عنه زميدكو
+
+27
+00:02:23,630 --> 00:02:29,070
+مادلين اللي هو اللا مركزية تبدأ
+
+28
+00:02:29,070 --> 00:02:33,170
+على ذلك وجود مسألة عن صلاحيات وحرية في اتخاذ
+
+29
+00:02:33,170 --> 00:02:37,560
+القرارممتاز تفويد الصلاحيات والسلطات معناه إن
+
+30
+00:02:37,560 --> 00:02:40,600
+المدراء لهم صلاحيات وحرية في اتخاذ القاعدة اللي هو
+
+31
+00:02:40,600 --> 00:02:47,160
+لا مركزية اتفضلي علاقة
+
+32
+00:02:47,160 --> 00:02:50,500
+رضية بين التفويد و لا مركزية كل ما زاد تفويد
+
+33
+00:02:50,500 --> 00:02:53,780
+السلطات كل ما زاد اللي لا مركزية و العكس أخر حاجة
+
+34
+00:03:03,250 --> 00:03:05,730
+الانحرافات اللي احنا خدناها انحرافات مفضلة
+
+35
+00:03:05,730 --> 00:03:08,010
+وانحرافات غير مفضلة اللي هو انقار من الفعلي
+
+36
+00:03:08,010 --> 00:03:11,290
+بالمخطط او المخطط بالفعلي الموازنات اللي احنا
+
+37
+00:03:11,290 --> 00:03:13,530
+خدناهم اللي هم الموازنات التشغيلية والموازنات
+
+38
+00:03:13,530 --> 00:03:17,010
+المرينة تستخدم لأداء في الرقابة في إيش في ضل
+
+39
+00:03:17,010 --> 00:03:23,090
+المركزية شكرا يا مريم فعلا
+
+40
+00:03:23,090 --> 00:03:29,950
+أنا هيكل تنظيمي بس خليني أصغر شوية شايفينه
+
+41
+00:03:29,950 --> 00:03:39,850
+أه؟و أين فيه تفويت في الشكل هذا؟ تفويت؟ أه مين
+
+42
+00:03:39,850 --> 00:03:42,330
+مفوض لمين؟ نس و مين لمين؟ الدرد المبيعات للمدير
+
+43
+00:03:42,330 --> 00:03:45,030
+المشروع اللي ده هد .. أه .. على .. معلش دلال
+
+44
+00:03:45,030 --> 00:03:49,010
+الشوة؟ مجلس الإدارة مفوض المهام .. بعض المهام
+
+45
+00:03:49,010 --> 00:03:51,570
+للمدير العام، المدير العام مفوض .. كلها مش بعضها
+
+46
+00:03:51,570 --> 00:03:54,750
+أه كل المهام .. المدير العام مفوض ل .. لدرد
+
+47
+00:03:54,750 --> 00:03:58,430
+المبيعات و بقية .. المدير العام مفوض صراحية فقط في
+
+48
+00:03:58,430 --> 00:04:01,900
+طريق المبيعات لمدير المبيعات أهالمدير المبيعات
+
+49
+00:04:01,900 --> 00:04:06,260
+مفقد بعض المهام لمدير الفرع التاني اللي مفقد مهامه
+
+50
+00:04:06,260 --> 00:04:09,120
+لقسم الأتان تقسم المصطلح الزمان؟ بارك الله فيك
+
+51
+00:04:09,120 --> 00:04:12,520
+شكرا، إذا من أعلى لأسفل وليس العكس، الطفولة بيجي
+
+52
+00:04:12,520 --> 00:04:18,420
+من أعلى لأسفل وليس إيش، العكس، تقسم المشيئات يهود
+
+53
+00:04:18,420 --> 00:04:23,830
+الشوة من حيث اتخاذ القوات إلى؟مؤسسات مركزية اللي
+
+54
+00:04:23,830 --> 00:04:27,050
+بتنفيها اتخاذ القرارات بيد الإدارة العليا فقط
+
+55
+00:04:27,050 --> 00:04:30,830
+ممنوع نعمل أي حاجة غير نرجع للإدارة العليا ومؤسسات
+
+56
+00:04:30,830 --> 00:04:34,250
+اللي هي بتكون كبيرة شوية بيكون فيها تفويت صلاحيات
+
+57
+00:04:34,250 --> 00:04:45,810
+ما المقصود يا هودة بالمؤسسات المركزية المؤسسات
+
+58
+00:04:45,810 --> 00:04:48,970
+المركزية اللي تركز القرارات اللي هي على الإدارة
+
+59
+00:04:48,970 --> 00:04:56,420
+العلياهان يا أخيات مافيش عندنا مؤسسة مركزية بحتة،
+
+60
+00:04:56,420 --> 00:05:00,880
+مافيش عندنا مؤسسة ليها مركزية بحتة، عبارة عن جمع
+
+61
+00:05:00,880 --> 00:05:05,840
+بين المركزية و إيش و لا مركزية، متى نرجع للمركزية
+
+62
+00:05:05,840 --> 00:05:12,750
+إذا كانت القوات حاسمة، مصيرية كفتح الفرع؟شراء آلة
+
+63
+00:05:12,750 --> 00:05:16,830
+اغلاق فرع مثلا إذا .. إذا كان القرار استراتيجي
+
+64
+00:05:16,830 --> 00:05:21,550
+بيكون إيش؟ مركزي أما القرارات اليومية زي الحضور و
+
+65
+00:05:21,550 --> 00:05:25,590
+الغياب و شراء حاجة مواد خام و إشي بتكون لا مركزية
+
+66
+00:05:25,590 --> 00:05:29,990
+يا غدير إذا مافيش مؤسسة مركزية بحتها مافيش مؤسسة
+
+67
+00:05:29,990 --> 00:05:33,050
+يا غدير لا مركزية بحتها بيكون الجامعة بين إيش؟ بين
+
+68
+00:05:33,050 --> 00:05:39,970
+الاتنين شكرا يا هدا أذكر مزايا اللي هي مركزية ان
+
+69
+00:05:39,970 --> 00:05:45,470
+ده فيات؟لمّا نفرض احنا الصلاحيات ونخلّي المدرّق
+
+70
+00:05:45,470 --> 00:05:47,850
+يتخد قرارات ونكون عندنا سرعة في اتخاذ أيش؟ في
+
+71
+00:05:47,850 --> 00:05:50,390
+الاستجابة للتغيرات، على طول من الصداف استعمال أفضل
+
+72
+00:05:50,390 --> 00:05:54,590
+وقت الإدارة العليا، استخدام المشاكل إلى حجم ممكن
+
+73
+00:05:54,590 --> 00:05:58,630
+تتعامل معاه ممتاز،
+
+74
+00:05:58,630 --> 00:06:01,210
+شكرا لك، لأن السرعة في الاستجابة للتغيرات على طول
+
+75
+00:06:01,210 --> 00:06:04,870
+بتاخد القرار لأنه معاه صلاحيات استعمال أفضل وقت
+
+76
+00:06:04,870 --> 00:06:07,010
+الإدارة العليا بدل ما تضيع وقتها في الأمور البسيطة
+
+77
+00:06:07,010 --> 00:06:16,430
+الروتونيةبيروح برطة فيه لستراتيجيات أخر حاجة
+
+78
+00:06:16,430 --> 00:06:21,610
+خد بالك تدريب وتقييم وتحفيز المدير على القيادة على
+
+79
+00:06:21,610 --> 00:06:24,650
+إيش؟ على القيادة لما يكون عندك تفريط صراحيات
+
+80
+00:06:24,650 --> 00:06:30,110
+معناها أنت بتمارسي القيادة شكرا نيدا اذكري عيوب
+
+81
+00:06:30,110 --> 00:06:34,150
+المركزية نوراند فضلي اتخذ قرارات غير مستشفى
+
+82
+00:06:34,150 --> 00:06:37,640
+المعرفة الدين والإدارةممكن المدير .. المدير اللي
+
+83
+00:06:37,640 --> 00:06:42,080
+احنا فوضنا له يسرح شوية يتاخد قرارات مابتعجبش اللي
+
+84
+00:06:42,080 --> 00:06:45,800
+دلاله ليها، دي مشكلة التكريف العام يضمن رفض أشهر
+
+85
+00:06:45,800 --> 00:06:50,880
+مدراء التراثين طبعا لا يعني لا مركزية و تفويت
+
+86
+00:06:50,880 --> 00:06:54,500
+صلاحيات أن نخلي الناس الشغل ع مزاجها، لأ كل ما
+
+87
+00:06:54,500 --> 00:06:59,720
+زادت اللا مركزية لازم
+
+88
+00:06:59,720 --> 00:07:09,260
+يزيد معاها رقابة كل ما توفرةنظام رقابة فعال كل ما
+
+89
+00:07:09,260 --> 00:07:14,300
+تشجعنا للمركزية
+
+90
+00:07:14,300 --> 00:07:20,900
+للمركزية عفوا شكرا و العكس مافيش رقابة مش هيكون
+
+91
+00:07:20,900 --> 00:07:25,000
+تحت عينك بلاش من الأصل ولا مركزية إذا متى بفوض
+
+92
+00:07:25,000 --> 00:07:30,640
+صلاحيات لما يكون عندى نظام رقابة قوي عساس خدى بالك
+
+93
+00:07:30,640 --> 00:07:34,340
+أخدت في السنة الأولى السلطة تفوض
+
+94
+00:07:36,440 --> 00:07:43,060
+ممتاز المسئولية لأ تفوض لأ يعني المدير يفوض انه
+
+95
+00:07:43,060 --> 00:07:45,720
+خلاص مش ده ولا هو المسئول عن جميع الأخطاء فياخد
+
+96
+00:07:45,720 --> 00:07:50,640
+باله ايضا بعض
+
+97
+00:07:50,640 --> 00:07:53,440
+الأوقات بيصير في عنا عمليات متشابهة يعني نفس
+
+98
+00:07:53,440 --> 00:07:56,180
+العمليات في نفس الأقصام فمين هيكون مسئول عنها هذا
+
+99
+00:07:56,180 --> 00:08:00,380
+بقدر صعوبة اياش التنسيق شكرا يا auntie ادكر يا ايا
+
+100
+00:08:00,380 --> 00:08:01,960
+العوض يعيوب اللي مركزية
+
+101
+00:08:25,940 --> 00:08:29,920
+المؤسسات لما تكون كبيرة مثلا عندنا شركة جوال عصابي
+
+102
+00:08:29,920 --> 00:08:32,720
+بالمثال شركة للصلاة، بنك فلسطين، بيعتمدوا على اللا
+
+103
+00:08:32,720 --> 00:08:36,080
+مركزية في شغلهم، ليش؟ لأن المؤسسات كبيرة، منتشرة،
+
+104
+00:08:36,080 --> 00:08:36,640
+يعني لها فروع
+
+105
+00:08:40,220 --> 00:08:44,220
+رقم اتنين المؤسسة بيقولين لها كده منتج، قالت بقى
+
+106
+00:08:44,220 --> 00:08:49,740
+جيم دالي، ثلاثة؟ إذا كان الزباين و المواردين عددهم
+
+107
+00:08:49,740 --> 00:08:54,680
+كبير، بنقول لها مركزية؟ اللي صُنع في اتخاذ القرار،
+
+108
+00:08:54,680 --> 00:08:58,980
+مافيش وقت نأجل،
+
+109
+00:08:58,980 --> 00:09:01,760
+حابين المديراء اللي في مستويات الدنيا يشاركوا في
+
+110
+00:09:01,760 --> 00:09:02,680
+اتخاذ القرار؟
+
+111
+00:09:05,230 --> 00:09:08,590
+أنا كيف أعرف مين القسم الناجح ونعمله تكريم حسب
+
+112
+00:09:08,590 --> 00:09:14,750
+تفويض إيش الصلاحيات شكرا يا أندري لغاية
+
+113
+00:09:14,750 --> 00:09:18,210
+هان هذه كانت مراجعة لأمور أنتوا أخدتوها قبل هيك في
+
+114
+00:09:18,210 --> 00:09:22,650
+إدارة واحد ماشي تعالوا ناخد حاجات جديدة شكرا يا
+
+115
+00:09:22,650 --> 00:09:29,750
+أندري أذكر أنواع الوحدات اللي مركزية يا أحلاممركز
+
+116
+00:09:29,750 --> 00:09:36,610
+التكلف ماركز التكلف ماركز التكلف
+
+117
+00:09:36,610 --> 00:09:37,410
+ماركز التكلف ماركز التكلف ماركز التكلف ماركز
+
+118
+00:09:37,410 --> 00:09:37,710
+التكلف ماركز التكلف ماركز التكلف ماركز التكلف
+
+119
+00:09:37,710 --> 00:09:37,950
+ماركز التكلف ماركز التكلف ماركز التكلف ماركز
+
+120
+00:09:37,950 --> 00:09:39,570
+التكلف ماركز التكلف ماركز التكلف ماركز التكلف
+
+121
+00:09:39,570 --> 00:09:43,490
+ماركز التكلف ماركز التكلف ماركز التكلف ماركز
+
+122
+00:09:43,490 --> 00:09:49,550
+التكلف ماركز التكلف ماركز
+
+123
+00:09:49,550 --> 00:09:55,130
+التكلف ماركز التكلف
+
+124
+00:09:59,030 --> 00:10:04,370
+المركز المسؤول عن التكاليف والاسعار والمعاصير فقط
+
+125
+00:10:04,370 --> 00:10:07,610
+وهذه
+
+126
+00:10:07,610 --> 00:10:12,450
+كتير تذكر في الصح والغلط ماشي؟ مركز التكلفة يكون
+
+127
+00:10:12,450 --> 00:10:17,670
+القسم فقط مسؤول عن التكاليف طب إيه رادات ماهوش
+
+128
+00:10:17,670 --> 00:10:23,730
+جعبة؟ أرباح مابتدخلشها يا سعيد ماشي؟ إذا المركز
+
+129
+00:10:23,730 --> 00:10:27,630
+المسؤول عن التكلفة فقط إيش بنسميه؟ مركز التكلفة
+
+130
+00:10:28,950 --> 00:10:39,770
+فضّلي كاملي تقليفة؟
+
+131
+00:10:39,770 --> 00:10:44,770
+ماخد بالك من ليس له؟ مانوش علاقة يعني، بس
+
+132
+00:10:44,770 --> 00:10:48,730
+التكاليف، أيوة؟
+
+133
+00:10:48,730 --> 00:10:55,370
+أقصد واحدة نشاط أو نجار مسئولية، أساسا أن الجميع
+
+134
+00:10:55,370 --> 00:11:00,330
+ناصر للتكاليفشكرا يا عزيزي، إذا المركز التكلفة هو
+
+135
+00:11:00,330 --> 00:11:05,870
+المركز المسؤول فقط عن حدوط التكاليف، لا علاقة له
+
+136
+00:11:05,870 --> 00:11:09,730
+لا بإيراد ولا بأرباح ولا بمبيعات، فقط عن إيش؟ عن
+
+137
+00:11:09,730 --> 00:11:14,630
+التكاليف، جداش هادا كلفني خمسة شكري فقط، جداش بيتي
+
+138
+00:11:14,630 --> 00:11:20,250
+مانبهاش مانلاش دعوة لأول جمعة صح تمام؟ طيب و لا
+
+139
+00:11:20,250 --> 00:11:23,070
+لازم يكون كلمة فقد عشان كنت صح؟ لأ إن جالك
+
+140
+00:11:23,070 --> 00:11:27,490
+التكاليف و سكت صحلكن لو جاب ناس ثانين زي
+
+141
+00:11:27,490 --> 00:11:32,310
+الإيرادات، أرباح، حاجة منها ومنها، غلط شكرني أنت
+
+142
+00:11:32,310 --> 00:11:37,950
+على السؤال إذا ما .. ما هو لعب لعال أو ما هو مركز
+
+143
+00:11:37,950 --> 00:11:45,570
+تكلفها لعب لعال؟ فقط،
+
+144
+00:11:45,570 --> 00:11:51,070
+شكرني أنتي أذكر أنواع مراكز التكلف أثنان، عندنا
+
+145
+00:11:51,070 --> 00:11:51,710
+أنواعين بس
+
+146
+00:11:55,630 --> 00:12:01,810
+الاستنسابية ما هي مقصود
+
+147
+00:12:01,810 --> 00:12:16,690
+بالتكلفة المعيارية مرّت علينا هذه قبل هيك
+
+148
+00:12:16,690 --> 00:12:20,770
+ما هي
+
+149
+00:12:20,770 --> 00:12:22,730
+مقصود بالتكلفة المعيارية مرّت علينا هذه قبل هيك ما
+
+150
+00:12:22,730 --> 00:12:24,010
+هي مقصود بالتكلفة المعيارية مرّت علينا هذه قبل هيك
+
+151
+00:12:24,010 --> 00:12:24,170
+ما هي مقصود بالتكلفة المعيارية ما هي مقصود
+
+152
+00:12:24,170 --> 00:12:26,700
+بالتكلفة المعيارية ما هي مقصود بالتبناء على خبرتي
+
+153
+00:12:26,700 --> 00:12:29,460
+في الشغل بقدر احددها بشكل دقيق زي ايش تكاليف
+
+154
+00:12:29,460 --> 00:12:33,500
+معيارية؟ زي تكاليف المواد المباشرة، الأجور، تكاليف
+
+155
+00:12:33,500 --> 00:12:36,280
+الصناعية المباشرة، هذه بنسميها تكاليف شمالها
+
+156
+00:12:36,280 --> 00:12:40,200
+معيارية شكرا، اتفضل يا إسمها، نكمل الاسم تنسابية
+
+157
+00:12:40,200 --> 00:12:45,060
+تنسابية ليش هيبقى بين المنتجات والمنخلات، فالقسم
+
+158
+00:12:45,060 --> 00:12:48,750
+الدعاية والإعلام، القسم التطبيب؟هذا مثلًا مثلًا
+
+159
+00:12:48,750 --> 00:12:54,570
+تقريبًا من تقليف الدعاية والمبيعات تقصنا
+
+160
+00:12:54,570 --> 00:12:59,970
+فعليات الدعاية المجموعة الانجاز .. شو كان يا انت
+
+161
+00:12:59,970 --> 00:13:04,470
+التكاليف الاستنسابية فش علاقة بين مخرجاتها
+
+162
+00:13:04,470 --> 00:13:10,110
+ومدخلاتها كيف يعني؟ مبيعاتنا زادت ومش بالضرورة
+
+163
+00:13:10,110 --> 00:13:12,910
+عشان مبيعاتي زادت ان وانا انجحت في الحملة الدعاية
+
+164
+00:13:12,910 --> 00:13:20,210
+مش قاعدة مش قاعدةماشي، إذا تكاليف السنسابية مافيش
+
+165
+00:13:20,210 --> 00:13:23,650
+علاقة بين مخرجاتنا ومدخولاتنا ع سبيل الميترال
+
+166
+00:13:23,650 --> 00:13:29,330
+تكاليف الدعاية إحدى المؤسسات مبيعاتها زادت، ليس
+
+167
+00:13:29,330 --> 00:13:34,330
+بالضرورة أن يكون السبب الجوهري لزيادة المبيعات
+
+168
+00:13:34,330 --> 00:13:38,880
+الدعايةممكن سبب تاني ممكن الدعاية مش مطلقة يعني
+
+169
+00:13:38,880 --> 00:13:43,200
+بيحكي إن الدعاية بنقصهاش احنا بمقدار المبلغ
+
+170
+00:13:43,200 --> 00:13:46,280
+المدفوعة اللي هي التكليف الدعاية بنقصها بمقدار إيش
+
+171
+00:13:46,280 --> 00:13:50,340
+الإنجاز جداش الناس يحكوا عن منتجي جداش الناس عندهم
+
+172
+00:13:50,340 --> 00:13:53,660
+رغبة في منتجي في الحالة هذه بصير أحكي إن الدعاية
+
+173
+00:13:53,660 --> 00:14:01,360
+ناجحة إذا لا يعني دفع أموال طائلة في الدعاية نجح
+
+174
+00:14:01,360 --> 00:14:08,540
+لا يعني ماشيو مش بالضرورة بس نعمل حملة إعلانية أو
+
+175
+00:14:08,540 --> 00:14:12,980
+دعائية ننجح و مبيعاتنا الزيد الكلامة ده إيش بنسميه
+
+176
+00:14:12,980 --> 00:14:17,960
+تكاليف استنسابية تكاليف إيش استنسابية واضحة ولا
+
+177
+00:14:17,960 --> 00:14:24,820
+عيدها عيدها تاني المركز التاني تفضليه إسلام
+
+178
+00:14:24,820 --> 00:14:27,120
+النحسان مركز الإيراد
+
+179
+00:14:37,160 --> 00:14:41,960
+شو كان يا انت؟ أخدت like من كلمة فقط؟ لكن الإيراد
+
+180
+00:14:41,960 --> 00:14:46,560
+هذا اللي قلنا عنه فقط، كيف بنحسبه؟ كيف بنحسب
+
+181
+00:14:46,560 --> 00:14:53,820
+إيراد؟إذا لو جالنا القسم المسؤول عن حدوط الكمية في
+
+182
+00:14:53,820 --> 00:14:58,960
+السعر، بطلع صح، خد بالك، عشان الإيراد يا أخوات مش
+
+183
+00:14:58,960 --> 00:15:04,900
+زي التكاليف، الإيراد إله قانون، Q في B، فممكن بدل
+
+184
+00:15:04,900 --> 00:15:08,020
+ما يقول حدوط الإيراد، تشيلها ويقول حدوط الكمية في
+
+185
+00:15:08,020 --> 00:15:12,910
+السعرنيجي نقوله غلط؟ لأ، العبارة شمالها صحيحة إذا
+
+186
+00:15:12,910 --> 00:15:16,210
+ناخدنا مع بعض مركز التكلفة الرسمالية، التكلف فقط،
+
+187
+00:15:16,210 --> 00:15:20,490
+مركز الإيراد، الإيرادات فقط، نشوف رقم تلاتة في
+
+188
+00:15:20,490 --> 00:15:24,830
+المراكز، مركز الربح، وخودي بالك منه، مين حاب
+
+189
+00:15:24,830 --> 00:15:27,950
+يشارك؟ إسلام أبو سيدو، تفضل يا عمتي، ما سمناكيش
+
+190
+00:15:27,950 --> 00:15:32,870
+اليوم عم، المتجد اللذان يقسم يشأت يكون يا مدير
+
+191
+00:15:32,870 --> 00:15:39,990
+المتجد من أربع دائرة قسم أو محدد، كمدرأ يكونكيف
+
+192
+00:15:39,990 --> 00:15:47,930
+بنحسب الربح؟ الإيراد ناقص التكاليف اه، إذا مركز
+
+193
+00:15:47,930 --> 00:15:52,690
+الربح بختلف عن الأثنين اللي جابوا مركز الربح هيكون
+
+194
+00:15:52,690 --> 00:15:56,310
+مسئول عن الإيرادات والتكاليف، ليش؟ عشان إحنا لما
+
+195
+00:15:56,310 --> 00:15:59,470
+نحسب الربح بنقول الربح بساوي الإيراد ناقص
+
+196
+00:15:59,470 --> 00:16:02,610
+التكاليف، إذا خدي بالك أن النقطة هذه، تفضلي كاملي
+
+197
+00:16:02,610 --> 00:16:06,110
+يا إسلام اه
+
+198
+00:16:09,430 --> 00:16:13,330
+اخدت بالك؟ معانا ليش معانا؟ لأن هو ده الربح، إيش
+
+199
+00:16:13,330 --> 00:16:16,430
+دخل الربح في الموضوع؟ ما هو الربح بساوي الإيراد
+
+200
+00:16:16,430 --> 00:16:20,230
+نقص التكاليف، ممتاز، فضل يعني عايز نخضع إيرادا و
+
+201
+00:16:20,230 --> 00:16:23,530
+تكاليف التكاليفي في نفس الحالة ممتاز، إذا أخدنا مع
+
+202
+00:16:23,530 --> 00:16:28,290
+بعض مركز التكاليف تكاليف فقط، يا يا سمور مركز
+
+203
+00:16:28,290 --> 00:16:33,750
+الإيرادات إيرادات فقط، كمية و سعر، مركز الربح لأ
+
+204
+00:16:33,750 --> 00:16:42,590
+إيراد و تكاليفشكرا يا اسلام مركز الاستثمار ..
+
+205
+00:16:42,590 --> 00:16:46,470
+تفضلي يا غدير من نفسك يلا يا عزيزي .. وهي أحسن
+
+206
+00:16:46,470 --> 00:16:49,570
+المنش التي يكون فيها مدير المركز مسئول عن حدوث
+
+207
+00:16:49,570 --> 00:16:52,870
+أرباح الإدارة التابعة له وأيضا عند استثمارها ..
+
+208
+00:16:52,870 --> 00:16:57,730
+استثمارات لأصولنا الاستثمار اللي هو الأصول زي ما
+
+209
+00:16:57,730 --> 00:16:58,870
+أنتوا عارفين أخدناها في المالين
+
+210
+00:17:13,830 --> 00:17:17,450
+وفي أدين الحالة يمتلك المدير هذا مركز أبواب ضخمة
+
+211
+00:17:17,450 --> 00:17:21,870
+وصلاحيات كبيرة لاتخاذ قرارات أسماليةزي ايش أصول
+
+212
+00:17:21,870 --> 00:17:26,510
+بده يشتريها؟ آلات .. آلات ممتاز، معدات، أرض، مبنى،
+
+213
+00:17:26,510 --> 00:17:29,250
+فلازم يكون مبلغ كبير، ممكناش مبلغ بسيطاش بشغلات
+
+214
+00:17:29,250 --> 00:17:33,090
+هالي، تفضلي تعتبر المحاسب بنظمية مسئولية .. بنظمية
+
+215
+00:17:33,090 --> 00:17:36,390
+مسئولية عن كل ما يتواصل بالاستثمار معين، من دون ما
+
+216
+00:17:36,390 --> 00:17:39,270
+يمكن محاسب المدير أو رئيس المركز الاستثماري عن
+
+217
+00:17:39,270 --> 00:17:43,990
+تكاليف الإيرادات الخاصة بالمركز والاستخدام .. مربح
+
+218
+00:17:43,990 --> 00:17:46,630
+.. مربح المال مستثمر بالمركز اللي هو العاد على
+
+219
+00:17:46,630 --> 00:17:49,050
+الاستثمار، أخدت مبلغ، جداش ربحه؟
+
+220
+00:17:53,680 --> 00:17:57,680
+الاستثماري اذا بناء على كلام رزمتك وغدير مركز
+
+221
+00:17:57,680 --> 00:18:01,860
+الاستثمار بنسميه مركز الشامل ليه الشامل؟
+
+222
+00:18:01,860 --> 00:18:06,880
+للإيرادات، للتكاليف، للأرباح، كل ما زادت أرباحنا
+
+223
+00:18:06,880 --> 00:18:11,480
+أصولنا مانا أحنا نجحين، كل ما قلت لأ، فخودي بالك،
+
+224
+00:18:11,480 --> 00:18:12,200
+شكرا يا غدير
+
+225
+00:18:16,220 --> 00:18:19,760
+أكبر تفويض يمنح لأي مركز في المراكز الأربعة هو
+
+226
+00:18:19,760 --> 00:18:27,440
+مركز إيش لسه اتمر لأن هو المسئول عنهم يالا
+
+227
+00:18:27,440 --> 00:18:33,400
+يا هدا الشوة خرج أهمية التفويت من مراكز القلاق إلى
+
+228
+00:18:33,400 --> 00:18:37,020
+استخدام مقاييس مفترقة تقنية الأداء لإستخدام مفترقة
+
+229
+00:18:37,020 --> 00:18:40,480
+مراكز القلاق انشفش يعني خاليكي معانا يا نادي
+
+230
+00:18:40,480 --> 00:18:44,340
+انشعسك يالا يا هدا مركز تقنية التقنية الأداء على
+
+231
+00:18:44,340 --> 00:18:46,120
+أساس المفارقة بين التجارب
+
+232
+00:18:51,370 --> 00:18:56,670
+إذا المركز التقليفة فقط تكاليف معيارية وفعلية بس
+
+233
+00:18:56,670 --> 00:19:08,770
+لا جال إيراد ولا غير، اتنين؟ مركز الربحية ختيف
+
+234
+00:19:08,770 --> 00:19:11,530
+الدول المالية كيف بنقيم ألباح المؤسسة عن طريق
+
+235
+00:19:11,530 --> 00:19:16,750
+أهالي المساهمة، ماشي؟الاربحية دي المبيعات ليه
+
+236
+00:19:16,750 --> 00:19:28,050
+الأرباح دي المبيعات؟ تفضلي مركز
+
+237
+00:19:28,050 --> 00:19:30,370
+الاستثمار اللي هو موضوعنا في هذا ال chapter
+
+238
+00:19:30,370 --> 00:19:33,410
+أخدناهم قبل هيك أخدنا مراكز التكلفة في ال chapter
+
+239
+00:19:33,410 --> 00:19:37,010
+اللي خلصناها في المحاضرة الماضية ومركز الربحية
+
+240
+00:19:37,010 --> 00:19:38,990
+أخدناها في chapter
+
+241
+00:19:41,200 --> 00:19:43,940
+العلاقة بين الحجب و الأرباح اللي هو نقطة التعادل
+
+242
+00:19:43,940 --> 00:19:47,420
+نسبة المبيعات و الكلام هذا نسبة المالية خدناها في
+
+243
+00:19:47,420 --> 00:19:49,420
+الإدارة المالية مانفعش أتطرق إليها أنا في المحاسبة
+
+244
+00:19:49,420 --> 00:19:52,620
+الإدارية ضال عنا حاجة واحدة احنا مش ماخدينها في
+
+245
+00:19:52,620 --> 00:19:58,100
+زمناتنا اللي هي مركز إيش الاستثمار مركز الاستثمار
+
+246
+00:19:58,100 --> 00:20:03,660
+هذه مرضين عليها توح حلوين الخرابيش اللي طالعين هنا
+
+247
+00:20:03,660 --> 00:20:07,100
+معطين
+
+248
+00:20:07,100 --> 00:20:14,580
+انطباع غريب شويةعاملين زي الطلاصم؟ مش حلوين؟ شكرا
+
+249
+00:20:14,580 --> 00:20:19,620
+يا عزيزي شكرا شكرا الصراحة انا ماعرف اقرأ منهم
+
+250
+00:20:19,620 --> 00:20:25,500
+طولة ماشي يا عزيزي ادخلي مزايا مراكز الاستثمار ده
+
+251
+00:20:25,500 --> 00:20:28,200
+مركز التكلفة مالاش دعوة فيه الإيراد مالاش دعوة فيه
+
+252
+00:20:28,200 --> 00:20:31,640
+احنا نمسك مركز ايش الاستثمار يلا يا حاجة هناد
+
+253
+00:20:31,640 --> 00:20:37,390
+انشاصيأتمنى تعملين اتخاذ القرار في شرائه منتجات
+
+254
+00:20:37,390 --> 00:20:41,130
+وامتدامات في الملاكز أخرى من داخل أو خارج الشركة
+
+255
+00:20:41,130 --> 00:20:45,670
+أو بيع المنتجات داخل أو خارج المنشأة لذلك يجب أن
+
+256
+00:20:45,670 --> 00:20:49,210
+تحديد أسعار هذه المنتجات بين الملاكز المختلفة داخل
+
+257
+00:20:49,210 --> 00:20:52,810
+المنشأة ليها أسعار التحويل أسعار إيش؟ التحويل
+
+258
+00:20:52,810 --> 00:20:57,250
+تعتمد على التكلفة و تقييم إجازة أقصى من المختلفة
+
+259
+00:20:57,250 --> 00:21:00,390
+ماشي ان شاء الله طبعا الكلام هذا هيكون سهل لما
+
+260
+00:21:00,390 --> 00:21:04,360
+ناخده بشكل عمليما هي طرق تقييم مراكز الاستثمار؟
+
+261
+00:21:04,360 --> 00:21:06,400
+عندنا طرقتين، اللي هم المحاضرة القادمة إن شاء
+
+262
+00:21:06,400 --> 00:21:10,080
+الله، اليوم مش هناخد عملي ال I.O.I. وماما عليكم
+
+263
+00:21:10,080 --> 00:21:15,640
+قبل هيك أو العادة الأصول يعني، والحاجة الجديدة
+
+264
+00:21:15,640 --> 00:21:19,940
+الداخلية المتبقية، هنبدأ فيهم إن شاء الله نعيشنا
+
+265
+00:21:19,940 --> 00:21:24,860
+المحاضرة الجاية، أي سؤال أو استفسار؟ أي سؤال؟
+
+266
+00:21:24,860 --> 00:21:25,720
+يعطيكوا العافية
+
diff --git a/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/r2Lb2YuBpMA_raw.json b/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/r2Lb2YuBpMA_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..26cdbb9d8314cb14b67f7b9ff781060b1103eda2
--- /dev/null
+++ b/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/r2Lb2YuBpMA_raw.json
@@ -0,0 +1 @@
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index 0000000000000000000000000000000000000000..4b41691bde645c8cc623ccbc8f8f21ea18aed3cb
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@@ -0,0 +1 @@
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label حلو مرتب لكن مافيش فيه حبر هستفيد منه؟ لأ .. إذا التكاليف المباشرة هي التكاليف المتعلقة بشكل مباشر و قوي بالمنتج التكاليف غير المباشرة لأ", "tokens": [3555, 3794, 3714, 7649, 2407, 8592, 7645, 3714, 7649, 3224, 33599, 37279, 28480, 6225, 995, 16254, 1975, 4117, 2655, 5172, 7578, 37893, 5296, 31377, 2304, 7251, 3555, 4587, 7578, 1975, 24793, 1211, 1975, 9381, 7649, 3615, 3224, 44381, 45164, 25724, 19528, 46740, 7645, 11331, 1211, 2407, 3714, 43500, 3555, 44381, 19446, 41185, 8592, 8978, 3224, 11331, 26890, 8032, 14851, 5172, 25708, 9154, 3224, 22807, 5296, 10721, 4386, 11933, 15730, 16712, 4117, 6027, 33911, 9673, 3555, 33599, 25720, 39896, 16712, 4117, 6027, 33911, 9673, 2655, 30241, 28671, 4724, 8592, 28820, 3714, 3555, 33599, 2288, 4032, 12174, 45865, 20666, 27842, 2655, 7435, 16712, 4117, 6027, 33911, 32771, 13546, 9673, 3555, 33599, 25720, 5296, 10721], "avg_logprob": -0.24253318373080904, "compression_ratio": 1.8888888888888888, "no_speech_prob": 1.7881393432617188e-07, 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إنه معطوني مصاري و اتصرفت فيها زي ما بدنا نين القدر على المفاوضات وهنا بصير في اختلاف بين المخطط ايش و الفعل أيضا تستخدم في اتخاذ قرارات المناقصات", "tokens": [1211, 19452, 45164, 50239, 4117, 5296, 10721, 5551, 4587, 1211, 9154, 3552, 17, 37893, 3714, 43020, 10632, 11778, 3224, 13412, 3615, 13546, 4117, 37893, 20666, 1829, 10721, 3794, 4724, 5016, 11622, 1863, 6055, 11622, 3615, 20292, 5296, 10721, 37893, 6225, 47302, 11622, 3660, 11933, 15730, 8717, 5016, 4117, 14407, 8978, 11296, 9122, 5172, 16606, 3660, 5551, 3215, 16606, 33688, 1211, 2655, 11622, 10943, 13672, 1829, 39896, 16247, 2304, 7649, 3660, 36145, 3224, 20449, 9566, 11536, 1829, 3714, 9381, 9640, 1829, 4032, 1975, 2655, 9381, 28480, 2655, 8978, 11296, 30767, 1829, 19446, 47525, 8315, 8717, 9957, 25062, 3215, 2288, 15844, 9673, 5172, 995, 2407, 11242, 9307, 37037, 8315, 4724, 9381, 13546, 8978, 1975, 46456, 15040, 5172, 49374, 9673, 9778, 9566, 9566, 1975, 1829, 8592, 4032, 27188, 30241, 36632, 11242, 995, 6055, 14851, 9778, 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1979.17, "word": " مباشرة،", "probability": 0.884423828125}, {"start": 1979.17, "end": 1979.57, "word": " إيرادية", "probability": 0.9822998046875}, {"start": 1979.57, "end": 1979.87, "word": " مثلا؟", "probability": 0.7115071614583334}, {"start": 1979.87, "end": 1979.91, "word": " أه", "probability": 0.955322265625}, {"start": 1979.91, "end": 1980.73, "word": " ممكن،", "probability": 0.9099934895833334}, {"start": 1980.73, "end": 1980.83, "word": " أنا", "probability": 0.171630859375}, {"start": 1980.83, "end": 1981.29, "word": " حكيتلك", "probability": 0.964599609375}, {"start": 1981.29, "end": 1981.57, "word": " ممكن", "probability": 0.863037109375}, {"start": 1981.57, "end": 1981.93, "word": " تلاقيها", "probability": 0.7939453125}, {"start": 1981.93, "end": 1982.29, "word": " تشترك", "probability": 0.980224609375}, {"start": 1982.29, "end": 1982.45, "word": " في", "probability": 0.95068359375}, {"start": 1982.45, "end": 1982.65, "word": " كذا", "probability": 0.97509765625}, {"start": 1982.65, "end": 1983.87, "word": " شغلة،", "probability": 0.8944091796875}, {"start": 1983.87, "end": 1984.03, "word": " في", "probability": 0.529296875}, {"start": 1984.03, "end": 1984.21, "word": " أي", "probability": 0.67333984375}, {"start": 1984.21, "end": 1985.77, "word": " سؤال؟", "probability": 0.912353515625}, {"start": 1985.77, "end": 1986.71, "word": " أي", "probability": 0.92431640625}, {"start": 1986.71, "end": 1987.31, "word": " سؤال", "probability": 0.9978841145833334}, {"start": 1987.31, "end": 1988.11, "word": " يعطيكوا", "probability": 0.86875}, {"start": 1988.11, "end": 1988.49, "word": " العافية", "probability": 0.9676106770833334}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 1988.69625, "duration_after_vad": 1853.015343749995}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/sBK_Ar_U6Rs_postprocess.srt b/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/sBK_Ar_U6Rs_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..1030357b18e5355a1012f92cff701779d081b52a
--- /dev/null
+++ b/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/sBK_Ar_U6Rs_postprocess.srt
@@ -0,0 +1,1348 @@
+1
+00:00:00,000 --> 00:00:01,100
+موسيقى
+
+2
+00:00:20,820 --> 00:00:23,220
+أعوذ بالله السمع والعلم من الشيطان الرجيم بسم الله
+
+3
+00:00:23,220 --> 00:00:27,380
+الرحمن الرحيم الحمد لله والصلاة والسلام على
+
+4
+00:00:27,380 --> 00:00:31,280
+المصطفى الأمين سيدنا محمد وعلى آله ومن ساره على
+
+5
+00:00:31,280 --> 00:00:34,220
+ربي .. على درج بيحسن من الدين في البداية السلام
+
+6
+00:00:34,220 --> 00:00:38,500
+عليكم ورحمة الله كيف حالكوا؟ كيف أصبحت اليوم ان
+
+7
+00:00:38,500 --> 00:00:44,120
+شاء الله بخير؟ كيف امتحاناتكوا؟ منيحة ان شاء الله؟
+
+8
+00:00:44,120 --> 00:00:49,420
+ان شاء الله في
+
+9
+00:00:49,420 --> 00:00:55,730
+المح? نعمان شاء الله يكون الصفتة خير، لأ سعيدة،
+
+10
+00:00:55,730 --> 00:00:58,250
+سعيدة اه، ان شاء الله تكونوا سعادة قلو
+
+11
+00:01:01,320 --> 00:01:04,760
+المحادرة الماضية خلصنا مع بعض الموازنات التشغيلية
+
+12
+00:01:04,760 --> 00:01:08,680
+شرحنا مع بعض موازنات التكاليف الإدارية قولنا نوعين
+
+13
+00:01:08,680 --> 00:01:11,880
+إما متغيرة أو تابتة موازن التكاليف التابتة أيها
+
+14
+00:01:11,880 --> 00:01:14,360
+كان نوعها تحسب بنفس الطريقة اللي هي النوعين نقدي
+
+15
+00:01:14,360 --> 00:01:18,480
+ودفتري واخدنا مع بعض موازنات التكاليف التسويقية
+
+16
+00:01:18,480 --> 00:01:21,780
+اليوم ان شاء الله هنحل قشوية أسئلة على هذا الموضوع
+
+17
+00:01:21,780 --> 00:01:26,560
+عندنا السؤال الرابع حلنا هذا السؤال في ال sheet لو
+
+18
+00:01:26,560 --> 00:01:33,270
+سمحت في ال sheetاقرأينا يا يهودة ونشوف مين حاب
+
+19
+00:01:33,270 --> 00:01:37,670
+يحلوا إلنا طلغة
+
+20
+00:01:37,670 --> 00:01:41,750
+التكاليف التابعة التسويقية 100 ألف دولار إذا نخد
+
+21
+00:01:41,750 --> 00:01:44,330
+بالك .. خدوا بالكوا من الأسفار يا جماعة الأسفار
+
+22
+00:01:44,330 --> 00:01:48,910
+بتطلع الحل غلط تكاليف التابعة التسويقية 100 ألف
+
+23
+00:01:48,910 --> 00:01:53,830
+والإهلاق منها 25 ألف دولار الإهلاق 25 ألف يعني رقم
+
+24
+00:01:53,830 --> 00:01:56,850
+صغير مقارنته يا غدير من 100 ألف ل 25 رقم بسيط
+
+25
+00:01:57,620 --> 00:02:02,700
+والشركة ومنتجين بلغت واحدة منهما أربعين بالمية أحس
+
+26
+00:02:02,700 --> 00:02:06,440
+بأحس بالموازنة التسوقية بلغت واحدة منها أربعين
+
+27
+00:02:06,440 --> 00:02:10,920
+بالمية أحس بموازنة تكريف ال ash التسوقية في عندك
+
+28
+00:02:10,920 --> 00:02:15,600
+كمان noon أربعة أشهر نoon اللي هي ash الأشهر عندنا
+
+29
+00:02:15,600 --> 00:02:20,920
+أربع أشهر ننحل السؤال هذا ونرجع نحل سؤال موازنة
+
+30
+00:02:20,920 --> 00:02:25,520
+التكريف الإدارية اللي في المحاضرة طبعا عشان امتحان
+
+31
+00:02:25,520 --> 00:02:34,030
+أنتوا بترجعوش ماشيمين يطلع يحلوا؟ ولا أحلوا أنا؟
+
+32
+00:02:34,030 --> 00:02:37,830
+هنقول
+
+33
+00:02:37,830 --> 00:02:46,510
+مع بعض موازنة التكاليف التسويقية التابعة عنا نون
+
+34
+00:02:46,510 --> 00:02:52,010
+.. كم شهر عنا نون يا غدير؟ واحد، اتنين، تلاتة،
+
+35
+00:02:52,010 --> 00:03:02,820
+اربع هنكتب هنا الإجمالي عناها التكاليفنقدي تكاليف
+
+36
+00:03:02,820 --> 00:03:10,140
+دفتري و بعدين الإجمالي من
+
+37
+00:03:10,140 --> 00:03:15,860
+وين هنجيب التكاليف النقدية و التكاليف الدفترية طب
+
+38
+00:03:15,860 --> 00:03:18,440
+نحكي هنا الأسئلة هال بتنحل .. بغطيكي بس رقمين
+
+39
+00:03:18,440 --> 00:03:24,040
+بتحلي فيهم كل الجدول حنيجي
+
+40
+00:03:24,040 --> 00:03:27,180
+هنحن نقول التكاليف التسويقية
+
+41
+00:03:28,930 --> 00:03:36,190
+مئة ألف بس خدي بالك في السؤال حكيلنا إن احنا عندنا
+
+42
+00:03:36,190 --> 00:03:42,890
+منتجين ماخد بالك؟ الشركة منتجين معايا بلغت واحدة
+
+43
+00:03:42,890 --> 00:03:46,090
+منها اربعين في المية اللي هو اللي احنا بنشتغل عليه
+
+44
+00:03:46,090 --> 00:03:53,370
+نسبة المنتج اربعين في المية قداش حكون ضايق للمنتج
+
+45
+00:03:53,370 --> 00:03:55,710
+التاني؟ اربعين في المية؟ لا كيف يا انت؟
+
+46
+00:03:58,850 --> 00:04:03,290
+ننسى 100 ألف و بقى أنا كل شغل هيكون على ال 40% مش
+
+47
+00:04:03,290 --> 00:04:06,850
+على ال 6 لإن هو طلب مني إن أنت تشتغل على منتج ب 40
+
+48
+00:04:06,850 --> 00:04:15,630
+% الحين 100 ألف دولار منها 40% جداش يعني؟ 40 ألف
+
+49
+00:04:15,630 --> 00:04:18,910
+ملناش
+
+50
+00:04:18,910 --> 00:04:22,710
+في هذا لإنه مش مطلوب لإن ال 40 ألف يا أخوات هقسمها
+
+51
+00:04:22,710 --> 00:04:30,430
+إلى نقدي و دفتريإذا بعد ما طلعنا نصيب منتجنا
+
+52
+00:04:30,430 --> 00:04:34,150
+هنقسمها إلى نقدي ودفتري زي ما أخدنا المحاضرة
+
+53
+00:04:34,150 --> 00:04:36,970
+الماضية بجيب الدفتر اللي هو الإهلاق بناء عليه بجيب
+
+54
+00:04:36,970 --> 00:04:41,030
+النقدي الآن قداش رقم الإهلاق كان يدلال في السؤال؟
+
+55
+00:04:41,030 --> 00:04:43,910
+خمسة وعشر .. خمسة وعشر ألف خمسة وعشر ألف السؤال
+
+56
+00:04:43,910 --> 00:04:46,850
+اللي بطرح نفسه جاوبناه المحاضرة الماضية هل الخمسة
+
+57
+00:04:46,850 --> 00:04:51,490
+وعشر ألف هتكون من الاربعين ولا من المية؟ ممتاز من
+
+58
+00:04:51,490 --> 00:04:55,190
+المية .. ممتاز طيب بتحكي بشواش؟ من المية .. لأ من
+
+59
+00:04:55,190 --> 00:05:00,540
+الميةلأنه الـ 100 ألف لاشركة ككل فإذا الـ 25 ألف
+
+60
+00:05:00,540 --> 00:05:08,840
+هتكون لاشركة ككل خمسة و عشرين تقسيم 100 ألف إذا
+
+61
+00:05:08,840 --> 00:05:13,660
+كان عندي ال .. الدفتر 25% كدهش النقد دي؟ مية نقص
+
+62
+00:05:13,660 --> 00:05:23,150
+25؟ 75% في حد بس لنفسه من وين جابه 25 و 75؟خودي
+
+63
+00:05:23,150 --> 00:05:25,810
+بالك أنا لما أقسم بقسم على الإجمالي مش على النسبة
+
+64
+00:05:25,810 --> 00:05:33,970
+الهلاك مش اللقب النسبة طيب أربعين ألف تقرب خمسة و
+
+65
+00:05:33,970 --> 00:05:39,110
+عشرين في المية ربع الخمسة و عشرين هيكون عشر تلاف
+
+66
+00:05:39,110 --> 00:05:43,370
+عشر
+
+67
+00:05:43,370 --> 00:05:47,930
+تلاف ممتازة هقسمهم على عدد الفترات اللي هي أربعة
+
+68
+00:05:47,930 --> 00:05:49,910
+عشر على أربعة الفين و خمس مية
+
+69
+00:05:52,870 --> 00:05:59,130
+هروح أجيب ال 2500 و أرحلهم هان اه
+
+70
+00:05:59,130 --> 00:06:03,270
+هي طولت عشان ال 40% لو فش كان على طول لازم أطلع
+
+71
+00:06:03,270 --> 00:06:08,030
+هنجداش 10000 واضح كيف جبتش الدفتري؟ إذا بعد ما
+
+72
+00:06:08,030 --> 00:06:14,200
+طلعنا نسبة الإهلاكضربناه في نصيب المنتج باه بطلع
+
+73
+00:06:14,200 --> 00:06:18,340
+عندنا رقم طب مايطلع رقم اصغنون لإن أنا 25% بقسمه
+
+74
+00:06:18,340 --> 00:06:21,660
+على الأربع فترات لإنه يجب أن يوزع بالتساوي مين
+
+75
+00:06:21,660 --> 00:06:25,860
+يجيب معي النقد دي؟ هذا هنقول خمسة وسبعين في المية
+
+76
+00:06:25,860 --> 00:06:35,220
+ضرب أربعين ألف كدهش بعطيكي؟ تلاتين ألف ممتازهذه
+
+77
+00:06:35,220 --> 00:06:38,800
+المرة الماضية حكينا لها طريقتين إما تقولي زي ما
+
+78
+00:06:38,800 --> 00:06:41,780
+توي عملت خمسة وسبعين في المية فاربعين ألف أو
+
+79
+00:06:41,780 --> 00:06:46,600
+أربعين ألف ناقص العشرة آلاف اللي هي الدفعة هيظل
+
+80
+00:06:46,600 --> 00:06:50,600
+تلاتين في كل الحالتين هيجيب نفس النتج تلاتين ألف
+
+81
+00:06:50,600 --> 00:06:55,060
+تقسيم أربعة سبعة
+
+82
+00:06:55,060 --> 00:07:02,300
+آف وخمسمية حقيقة جهان أرصد سبعة آف وخمسمية سبعة آف
+
+83
+00:07:02,300 --> 00:07:07,000
+وخمسميةسبعة تلاف و خمسمية، سبعة تلاف و خمسمية،
+
+84
+00:07:07,000 --> 00:07:10,860
+الاصل يكون مقداش تلاتين ألف، المفروض يكون الظقم
+
+85
+00:07:10,860 --> 00:07:14,520
+أربعين ألف، سبعة تلاف و خمسمية زاد ألفين و خمسمية،
+
+86
+00:07:14,520 --> 00:07:19,100
+كمش بيعطيني؟ عشرة تلاف، عشرة تلاف، عشرة تلاف، عشرة
+
+87
+00:07:19,100 --> 00:07:27,880
+تلاف، عشرة تلاف، عشرة تلاف، عشرة تلاف، عشرة تلاف،
+
+88
+00:07:27,880 --> 00:07:29,640
+عشرة تلاف، عشرة تلاف، عشرة تلاف، عشرة تلاف، عشرة
+
+89
+00:07:29,640 --> 00:07:29,920
+تلاف، عشرة تلاف، عشرة تلاف، عشرة تلاف، عشرة تلاف،
+
+90
+00:07:29,920 --> 00:07:29,960
+عشرة تلاف، عشرة تلاف، عشرة تلا
+
+91
+00:07:38,000 --> 00:07:42,760
+حلنا السؤال الخامس؟ لأ، ماشي بس قبل ما نحل السؤال
+
+92
+00:07:42,760 --> 00:07:50,260
+الخامس في
+
+93
+00:07:50,260 --> 00:07:54,060
+أي حاجة على الصابورة مش واضحة؟ في أي حاجة على
+
+94
+00:07:54,060 --> 00:07:57,320
+الصابورة مش واضحة أعيدها؟ في أي حاجة مش واضحة
+
+95
+00:07:57,320 --> 00:08:01,400
+أعيدها؟ سهل ولا صعب؟ في حاجة أعيدها؟
+
+96
+00:08:06,560 --> 00:08:09,480
+في عيننا يا أخوات اللي هو example تبع موازنة
+
+97
+00:08:09,480 --> 00:08:15,820
+التكاليف الإدارية، المحاضرة الماضية احنا
+
+98
+00:08:15,820 --> 00:08:20,180
+حسبنا التكاليف المتغيرة، الموازنة بتاعتها، اللي هي
+
+99
+00:08:20,180 --> 00:08:23,460
+not ضبو خلاص، طب هل حسبنا التكاليف التابع، تشوفي
+
+100
+00:08:23,460 --> 00:08:27,980
+إن أنا يهودة؟ أنا مش ذاكرة أني تركت إشي للآن
+
+101
+00:08:31,680 --> 00:08:35,880
+ماشي نجيب اللد وصفد للمونتاج X وانتوا جيبوا اللد
+
+102
+00:08:35,880 --> 00:08:41,900
+وصفد للمونتاج Y إذا نرجع لمثال المحاضرة عشان ضال
+
+103
+00:08:41,900 --> 00:08:47,080
+في حاجة بدنا نحلها أمسح الصابورة؟ أمسح يا جماعة؟
+
+104
+00:08:47,080 --> 00:08:53,400
+أمسحها؟
+
+105
+00:09:03,010 --> 00:09:11,650
+اتفضلي يا دالالك و ايه لنا السؤال؟ دالال إيش هو؟
+
+106
+00:09:11,650 --> 00:09:17,350
+بلبت مبيعات شركة ارفوس للمواضعات المنزلية في ال
+
+107
+00:09:17,350 --> 00:09:23,070
+LED المنتج في ال LED وصفد؟و إيه كتير؟ المنتج Y
+
+108
+00:09:23,070 --> 00:09:31,490
+15000 و المنتج X 2001 لل LED و بالنسبة للمنتج Y
+
+109
+00:09:31,490 --> 00:09:37,990
+30000 و المنتج X 4000 كل واحدة صفت سعر باير الوحدة
+
+110
+00:09:37,990 --> 00:09:42,970
+10 دينار و التحليف الإدارية 65640 دينار و الإغلاق
+
+111
+00:09:42,970 --> 00:09:48,250
+13128 دينار احسبي موازنة التكاريف الإدارية شكرا
+
+112
+00:10:04,610 --> 00:10:11,070
+طبعا هذه التابعة نون
+
+113
+00:10:11,070 --> 00:10:20,550
+واحد، اثنين، تلاتة، معطلة في السؤال نقضي هذه للد
+
+114
+00:10:20,550 --> 00:10:24,690
+دفتري
+
+115
+00:10:24,690 --> 00:10:29,850
+إجمال
+
+116
+00:10:40,520 --> 00:10:50,120
+قدش هنا التكاليف التابع في السؤال؟ رقم
+
+117
+00:10:50,120 --> 00:10:56,880
+غريب عندك
+
+118
+00:10:56,880 --> 00:11:03,720
+led وصفد طبعا
+
+119
+00:11:03,720 --> 00:11:08,660
+خد بالك هذا بالدولار قدش نسبة مبيعات ال led؟
+
+120
+00:11:14,010 --> 00:11:19,110
+ألفين وحدة من X للإتنين آه خودي بالك ألفين وحدة بس
+
+121
+00:11:19,110 --> 00:11:22,510
+إحنا بنشتغل على إيه الشهودة؟ على الجمال هنقول ال
+
+122
+00:11:22,510 --> 00:11:35,110
+LED طبعا هو الحل هيكون Q في B سابورة
+
+123
+00:11:35,110 --> 00:11:40,490
+ساعة صغيرة ال LED هتساوي جداش مبيعات ال LED ل X؟
+
+124
+00:11:44,160 --> 00:11:50,840
+قدمش السعر؟ عشرة طيب
+
+125
+00:11:50,840 --> 00:11:56,560
+مابعد Y اللي دي؟ خمس عشر ألف حسبيها ماشي السعر زي
+
+126
+00:11:56,560 --> 00:12:00,200
+ما هو عشرة صفد؟
+
+127
+00:12:00,200 --> 00:12:06,040
+مين يعمل صفد؟ ناس؟ يلا يا غدير عشرة أربع تلاف
+
+128
+00:12:06,040 --> 00:12:12,700
+واحدة و السعر عشرة ل X او ل Y اللي هو تلاتين ألف و
+
+129
+00:12:12,700 --> 00:12:15,790
+السعر عشرةممتاز، قدريش بيعطيك ايه؟ تلاتين اللي هو
+
+130
+00:12:15,790 --> 00:12:21,990
+تلاتين ألف، ايه تلاتين ألف احسبيها اربعة في عشر
+
+131
+00:12:21,990 --> 00:12:25,930
+زائد تلاتة في عشرة تلاتين واربعين تلاتين واربعين
+
+132
+00:12:25,930 --> 00:12:28,470
+تلاتين واربعين تلاتين واربعين تلاتين واربعين
+
+133
+00:12:28,470 --> 00:12:28,730
+تلاتين واربعين تلاتين واربعين تلاتين واربعين
+
+134
+00:12:28,730 --> 00:12:28,910
+تلاتين واربعين تلاتين واربعين تلاتين واربعين
+
+135
+00:12:28,910 --> 00:12:29,070
+تلاتين واربعين تلاتين واربعين تلاتين واربعين
+
+136
+00:12:29,070 --> 00:12:36,210
+تلاتين واربعين تلاتين واربعين تلاتين واربعين
+
+137
+00:12:36,210 --> 00:12:41,170
+تلاتين واربع
+
+138
+00:12:41,940 --> 00:12:45,820
+لازم يكون عند المبيعات بالدولار، يا اما بيعطينا
+
+139
+00:12:45,820 --> 00:12:48,860
+المبيعات في الدولار زي سؤالته، يا اما المبيعات
+
+140
+00:12:48,860 --> 00:12:53,620
+بالوحدةإذا كانت المبيعات بالوحدة بيعطينا السعر
+
+141
+00:12:53,620 --> 00:12:56,780
+لإيش السعر؟ تضغي بالمبيعات بالوحدة بتجيبي إيراد
+
+142
+00:12:56,780 --> 00:13:01,240
+إيش المبيعات؟ الآن اكتشفت إن أجمال مبيعات ال LED
+
+143
+00:13:01,240 --> 00:13:08,320
+170 و أجمال مبيعات صفد 340 كل هذا عشان أطلع نسبة
+
+144
+00:13:08,320 --> 00:13:11,960
+ال LED من أجمال إيش المبيعات؟ هنقول يا أخواتي إيه
+
+145
+00:13:11,960 --> 00:13:20,640
+ده من الإجمال؟ حساوة 170 ألف مبيعات صفد ال LEDزائد
+
+146
+00:13:20,640 --> 00:13:26,180
+تلاتمية و أربعين ألف جداش بيعطيك يا أبصار؟ واحد و
+
+147
+00:13:26,180 --> 00:13:30,380
+خمسين .. واحد و خمسين ألف ولا خمسمية و عشرة؟ واحد
+
+148
+00:13:30,380 --> 00:13:34,720
+و خمسين .. ماشي واحد
+
+149
+00:13:34,720 --> 00:13:45,080
+و خمسين ألف هنقسمه قسمين led صفد جداش
+
+150
+00:13:45,080 --> 00:13:53,480
+مبيعات ال led؟ مية و سبعين ألفتقسيم الـ 510 كداش
+
+151
+00:13:53,480 --> 00:13:58,880
+مبيعات صفد أكبر، 340 ألف، هتطلع أعلى هذه، تقسيم
+
+152
+00:13:58,880 --> 00:14:04,140
+510 طلعينا القسمة لو سمحتي، حاصر القسمة، إذا هقسم
+
+153
+00:14:04,140 --> 00:14:12,580
+170 اللي عاملنا مشاكل على فكرة 170
+
+154
+00:14:12,580 --> 00:14:14,140
+تقسيم من 510
+
+155
+00:14:16,760 --> 00:14:26,320
+340 هذه 340 هي صفت الخريطة
+
+156
+00:14:26,320 --> 00:14:32,140
+هذه ماشي هكمل هناك يا جماعة لغاية 510 في حد فاهم
+
+157
+00:14:32,140 --> 00:14:36,860
+حاجة اللي هي إجمال المبيعات بالدولار لصفد وال LED
+
+158
+00:14:36,860 --> 00:14:46,000
+510 اللي هي الإجمالي بدي أطلعها كنسبة يا أخوات لد
+
+159
+00:14:47,130 --> 00:14:52,910
+صفت ال LED مبيعاتها 140 ألف دولار خودي بيك من
+
+160
+00:14:52,910 --> 00:15:03,190
+الدولار صفت 340 ألف 33% حاضر يعني عشان أجيب النسبة
+
+161
+00:15:03,190 --> 00:15:10,450
+و أرجع أحل السؤال ده قسم 170 على 510 340 على 510
+
+162
+00:15:10,450 --> 00:15:16,940
+170 رقم صغني و انت قسمه 510 كده شباطيني؟إذا كانت
+
+163
+00:15:16,940 --> 00:15:21,800
+LED تلاتة و تلاتين في المية، جداش صفد؟ ستة و ستين
+
+164
+00:15:21,800 --> 00:15:29,480
+في المية إذا كل هذا عشان أجيب إيش؟ النسبة
+
+165
+00:15:29,480 --> 00:15:33,000
+تلاتة و ستين في المية، تلاتة و تلاتين في المية،
+
+166
+00:15:33,000 --> 00:15:34,680
+تلاتة و تلاتين في المية، تلاتة و تلاتين في المية،
+
+167
+00:15:34,680 --> 00:15:34,760
+تلاتة و تلاتين في المية، تلاتة و تلاتين في المية،
+
+168
+00:15:34,760 --> 00:15:34,780
+تلاتة و تلاتين في المية، تلاتة و تلاتين في المية،
+
+169
+00:15:34,780 --> 00:15:36,220
+تلاتة و تلاتين في المية، تلاتة و تلاتين في المية،
+
+170
+00:15:36,220 --> 00:15:37,880
+تلاتة و تلاتين في المية، تلاتة و تلاتين في المية،
+
+171
+00:15:37,880 --> 00:15:39,960
+تلاتة و تلاتين في المية، تلات
+
+172
+00:15:45,350 --> 00:15:50,690
+إذن تساوي صفة صوفة في البيت لحالكوا خمسة وستين ألف
+
+173
+00:15:50,690 --> 00:15:54,230
+وستمية واربعين ضرب تلاتة و تلاتين فمية، جيش
+
+174
+00:15:54,230 --> 00:15:57,370
+بيعطينا؟
+
+175
+00:15:57,370 --> 00:16:04,490
+آه
+
+176
+00:16:04,490 --> 00:16:07,390
+يا قوم؟ واحد وعشر ألف ستمية واحد وستين
+
+177
+00:16:13,260 --> 00:16:15,960
+برضه لأ هنقسمه قسمين هادي تكليف التابعه هنقسمه
+
+178
+00:16:15,960 --> 00:16:24,620
+قسمينه نقدي و دفتري ببدأ
+
+179
+00:16:24,620 --> 00:16:28,300
+بالدفتر و بروح للنقدي قداش عندك رقم اللي لك كان في
+
+180
+00:16:28,300 --> 00:16:35,940
+السؤال تلات عشر ألف ومية و تمانية و عشرين تمانية و
+
+181
+00:16:35,940 --> 00:16:40,720
+عشرينلسه توشرحينها لما أجيب الدفتر بقص مرة عجباني
+
+182
+00:16:40,720 --> 00:16:44,280
+التكاريف التابعة مش على نصيب المنطقة أو المنتج من
+
+183
+00:16:44,280 --> 00:16:48,520
+السؤال
+
+184
+00:16:48,520 --> 00:16:59,400
+اللي هو الإهلاك جداش بيعطينا النسبة إذا
+
+185
+00:16:59,400 --> 00:17:02,640
+كان الدفتر عشرين في المية جداش النقدي تمانين
+
+186
+00:17:06,950 --> 00:17:23,870
+خطوات متسلسلة الدفتر
+
+187
+00:17:23,870 --> 00:17:26,090
+اللي هو الهلاك على أجمعية تكاريف التسويق البطنية
+
+188
+00:17:26,090 --> 00:17:27,790
+في السؤال، مالوش علاقة بهذا
+
+189
+00:17:32,390 --> 00:17:36,430
+21,661 في 20% جايش بيعطينا أه بالمعنى أه لأ أيه و
+
+190
+00:17:36,430 --> 00:17:41,010
+لأ أكمل
+
+191
+00:17:41,010 --> 00:17:45,490
+ماعرفش إن أنا بحل فوق بلقى أحنا بننزل تحت أربع
+
+192
+00:17:45,490 --> 00:17:49,510
+تلاف تلاتمية
+
+193
+00:17:49,510 --> 00:17:58,370
+تنين و تلاتين تقسيم جداش تلاتة جداش النتش نهائي
+
+194
+00:18:01,530 --> 00:18:05,350
+hi miss هاد
+
+195
+00:18:05,350 --> 00:18:10,770
+ماشي اللقب هاد هناك أنا قسمت عشان أشوف مبيعات ال
+
+196
+00:18:10,770 --> 00:18:15,750
+led من إجمالي مبيعات ال led وصفت جداش ماشي تو احنا
+
+197
+00:18:15,750 --> 00:18:19,050
+حلنا السؤال اللي هو موازن التكاليف اللي هو السؤال
+
+198
+00:18:19,050 --> 00:18:23,810
+الرابع تو حلناه مع بعض بيحكيلي و لشركة منتجين بلغت
+
+199
+00:18:23,810 --> 00:18:28,810
+واحدة من 40% هادي معطينيها جاهزة سؤال محاضر لأ أنا
+
+200
+00:18:28,810 --> 00:18:33,470
+جبتها اللي هي جداش 33%يعني ممكن يكونوا حاسبها ممكن
+
+201
+00:18:33,470 --> 00:18:39,490
+احنا نجيبها عادي ايش هزلت على ال 4000 و 333؟ عشرين
+
+202
+00:18:39,490 --> 00:18:43,430
+فالمية ضارب تكاليف التابعة التسويقية اللي هي
+
+203
+00:18:43,430 --> 00:18:47,650
+التكاليف النقدية عفوا دفترية ده ليش بيعطيني النتج
+
+204
+00:18:47,650 --> 00:18:51,430
+احنا راسده ألف و أربعمية و أربعة و أربعين ألف و
+
+205
+00:18:51,430 --> 00:18:55,370
+أربعمية و أربعة و أربعين و أربعين و أربعين و
+
+206
+00:18:55,370 --> 00:18:55,650
+أربعين و أربعين و أربعين و أربعين و أربعين و
+
+207
+00:18:55,650 --> 00:18:55,770
+أربعين و أربعين و أربعين و أربعين و أربعين و
+
+208
+00:18:55,770 --> 00:18:56,630
+أربعين و أربعين و أربعين و أربعين و أربعين و
+
+209
+00:18:56,630 --> 00:19:02,620
+أربعين و أربعنفس الحال يا أخوات بصير خطوة لزيادة
+
+210
+00:19:02,620 --> 00:19:09,700
+كيف من ونا أجيب النسب لازم يعطينا جداش أربعة
+
+211
+00:19:09,700 --> 00:19:14,200
+تلاتة ثلاثة اتنين ضال عندنا النقد نكت بابلون تاني
+
+212
+00:19:14,200 --> 00:19:18,840
+تمانين
+
+213
+00:19:18,840 --> 00:19:22,360
+فالمية ضال بواحد عشرين سبعتاشر الف تلاتمية و
+
+214
+00:19:22,360 --> 00:19:27,220
+تمانية و عشرين تلاتمية و تمانية و عشرين ع تلاتة
+
+215
+00:19:31,230 --> 00:19:36,270
+5776 شو كانيه أنتي؟
+
+216
+00:19:36,270 --> 00:19:40,130
+أعيدها؟
+
+217
+00:19:40,130 --> 00:19:47,850
+أه أعيد بقصة كتير هذي لزرقها؟ أه حاضر
+
+218
+00:19:47,850 --> 00:19:53,190
+نفس الخطوات يا جماعة بنعيد و بنزيد قاعدين ضربنا
+
+219
+00:19:53,190 --> 00:19:56,670
+الـ 80% في التكليف التابعة التسويقية نصيب الـ LED
+
+220
+00:19:58,410 --> 00:20:00,990
+طلع عندك ألف .. سبعتاشر ألف تلاتمين و تمانية و
+
+221
+00:20:00,990 --> 00:20:07,810
+عشرين أنا عندي تلات شهور قسمتها تلاتة
+
+222
+00:20:07,810 --> 00:20:16,070
+قدش
+
+223
+00:20:16,070 --> 00:20:27,970
+بطلع هنا يهود الأفقي؟ سبعتلاف؟ قعدت تاني؟
+
+224
+00:20:29,650 --> 00:20:33,510
+أعيدها؟ إذن في كان عندنا في السؤال تبع المحاضرة
+
+225
+00:20:33,510 --> 00:20:39,450
+فكرة جديدة أو فكرة زيادة لو ما أعطيناش نسبة المنتج
+
+226
+00:20:39,450 --> 00:20:43,170
+طبعاً هيكون معطيكي بيانات أخرى تساعد على أن أحنا
+
+227
+00:20:43,170 --> 00:20:49,990
+نجيبها، ماشي؟ بنجيب النسبة و بنحل العادي، تفضلي
+
+228
+00:20:49,990 --> 00:20:56,170
+ننزل من أربع آلاف تلاتين لتلاتين دولة، نقسم فيها
+
+229
+00:20:56,170 --> 00:21:01,450
+20%قسمها على ضرب؟ ضرب .. ضرب .. عادي؟ اه ضربنا يا
+
+230
+00:21:01,450 --> 00:21:05,130
+انت اللي هي ال 20% يمشي مع اللون الأحمر فيه تكاريف
+
+231
+00:21:05,130 --> 00:21:08,130
+التابعة التسوقية .. انا تحت علشان اكتب ولا تضرب ..
+
+232
+00:21:08,130 --> 00:21:11,750
+ماهم اكتب على الحيط يعنى .. انا كتبت بالأحمر عشان
+
+233
+00:21:11,750 --> 00:21:16,850
+اميزها ما .. ماضلش مكان .. جيبنا ال 20 قسمنا ال
+
+234
+00:21:16,850 --> 00:21:21,230
+reflect على ال ..اه هذه العشرين هي نسبة الدفتري
+
+235
+00:21:21,230 --> 00:21:24,970
+اللي هو الهلاك على التكاليف التسوقية زي ما توحلنا
+
+236
+00:21:24,970 --> 00:21:30,170
+إذا كان الدفتر عشرين النقد يجدش تمانين شكرا على
+
+237
+00:21:30,170 --> 00:21:42,390
+السؤال بقى اللي عندنا السؤال الخامس أخدنا
+
+238
+00:21:42,390 --> 00:21:47,510
+زيه على فكرة السؤال الخامس قراينا أياه دلال حجاج؟
+
+239
+00:21:48,790 --> 00:21:52,890
+لحظة خلصوا يا أخوات و لا أعيدوا؟ خلصوا السؤال هذا
+
+240
+00:21:52,890 --> 00:21:57,110
+شامل مش معطينا المنتجات فشوفنا كيف أجيب إيه النسبة
+
+241
+00:21:57,110 --> 00:22:00,330
+يا ده تتحلوا في البرقة في البيت عفوا الموازنة تصفد
+
+242
+00:22:00,330 --> 00:22:06,110
+و تسلموا ليها في ممكنية تحلوا صفد؟ طبعا جاهز الحل
+
+243
+00:22:06,110 --> 00:22:10,890
+لإن أحنا حلناها أصلا جاهز السؤال صفد نصيبها ستة و
+
+244
+00:22:10,890 --> 00:22:14,710
+ستين هتاخديه و تشغلي عادي هان هتكملي هان الشغل
+
+245
+00:22:14,710 --> 00:22:22,070
+اللي ورايا ماشي؟ في حدا فيكم من ال LED؟فيش حد اه؟
+
+246
+00:22:22,070 --> 00:22:26,590
+طب نصفد؟ فيش حد اه؟ طب في حد كيف .. فيكوا قاعد فى
+
+247
+00:22:26,590 --> 00:22:32,710
+المحو قدر و لا كيف؟ نعم، كل كوا طب كويس طب كويس،
+
+248
+00:22:32,710 --> 00:22:44,110
+يلا يا جماعة، يلا يا .. دلال حجاج أول
+
+249
+00:22:44,110 --> 00:22:48,930
+سؤال هتسألى لنفسك يا دلال و غدية المبيعات بالوحدة
+
+250
+00:22:48,930 --> 00:22:53,250
+ولا بالدولار؟ما هو لو بالبحث ده مانفعش أحل السؤال
+
+251
+00:22:53,250 --> 00:23:03,010
+كاملة دلال اتفضلي اه ماعطيك ال price يهودة مش لله
+
+252
+00:23:03,010 --> 00:23:14,510
+ممتاز ايه ممتاز يلا حسبلك
+
+253
+00:23:14,510 --> 00:23:19,510
+النسبة خد ببالك السؤال هذا جاهزمش يقول يقولي وانا
+
+254
+00:23:19,510 --> 00:23:22,790
+الإهلاك بلا نقص مولا، هو جاهز، إذا كان الإهلاك
+
+255
+00:23:22,790 --> 00:23:26,250
+عشرين في المية اللي هو الدفتري، قداش حيكون النقضي؟
+
+256
+00:23:26,250 --> 00:23:30,310
+تمانين، وانتي ماشية، إذا يا أخوات في السؤال هادي،
+
+257
+00:23:30,310 --> 00:23:36,630
+هذا، الخطوة هادي هو .. عفوا، هادي هو عملها، وينها؟
+
+258
+00:23:36,630 --> 00:23:40,410
+هادياحنا دايما يوم نقسم الإهلاق على جمال التكاريف
+
+259
+00:23:40,410 --> 00:23:44,230
+التابعة عشان أجيب نسبة الإهلاق الدافتر و أجيب
+
+260
+00:23:44,230 --> 00:23:48,490
+النقضي في السؤال هذا هو حاسبه جايلك الإهلاق كان 20
+
+261
+00:23:48,490 --> 00:23:52,470
+% بتقولش يلا نقسم لا نقسم ولا حاجة ما هو قاسم و
+
+262
+00:23:52,470 --> 00:23:57,350
+جاهز إذا كان الإهلاق كان 20% يجداش النقضي 80% واضح
+
+263
+00:23:57,350 --> 00:24:00,750
+ولا عيدها؟ إذا ما في أسئلة بتعطيك المعطلات جاهزة
+
+264
+00:24:00,750 --> 00:24:04,870
+وفي أسئلة لأ حسب تفضلي كم ليه؟ و نسبة التكاريف
+
+265
+00:24:04,870 --> 00:24:10,320
+المتناهية 20%خُد بالك من السؤال، ما جالش موازنة؟
+
+266
+00:24:10,320 --> 00:24:15,940
+جال موازنات، عنا احنا موازنتين بس، موازنة التكليف
+
+267
+00:24:15,940 --> 00:24:20,820
+الإدارية التابعة، هذه بعدين، وموازنة تكليف
+
+268
+00:24:20,820 --> 00:24:24,080
+الإدارية المتغيرة، ليه الأسهم اللي هنجيبها الآن؟
+
+269
+00:24:24,080 --> 00:24:29,000
+مين حابب يطلع يجيب موازنة تكليف الإدارية المتغيرة؟
+
+270
+00:24:29,000 --> 00:24:33,680
+هدفه، هدفه، هدفههذا اللي هو المبيعات في الوحدة في
+
+271
+00:24:33,680 --> 00:24:36,640
+هذا اللي هو السعر في هذا اللي هي نسبة التكاليف
+
+272
+00:24:36,640 --> 00:24:41,820
+المتغيرة نحل السؤال آه آه يالا يالا نمسحلك
+
+273
+00:24:41,820 --> 00:24:48,300
+الصابورة يا انتي خلصتوا أه و
+
+274
+00:24:48,300 --> 00:24:55,220
+لا هتعمل موازن تكاليف المتغيرة سؤال
+
+275
+00:24:55,220 --> 00:24:56,980
+جاهز يا ريت هيجي زيه دايما
+
+276
+00:25:00,370 --> 00:25:04,930
+مين يتبرع يطلع يجيب موازنة تكاريف التابعة؟ سهلة
+
+277
+00:25:04,930 --> 00:25:16,350
+أول
+
+278
+00:25:16,350 --> 00:25:21,150
+حاجة يولا ابنك تب نون مش المبيعات اعملي عمود النون
+
+279
+00:25:21,150 --> 00:25:27,050
+ايوة جداش عندك كيف هي النون؟ واحد، اتنين، تلاتة،
+
+280
+00:25:27,050 --> 00:25:33,220
+تالتة شهور اعطوها لو ماشي السعر البيعالتكاليف ..
+
+281
+00:25:33,220 --> 00:25:38,080
+نسبة التكاليف المتغيرة بعدين
+
+282
+00:25:38,080 --> 00:25:42,160
+موازنة .. الموازنة ماشي عندك المبيعات بالوحدة
+
+283
+00:25:42,160 --> 00:25:45,680
+اعطوه الأرقام يا عياس عيد أيوة؟ مية و خمس ألف ..
+
+284
+00:25:45,680 --> 00:25:48,780
+لأ مش مختلفة .. و مستعشر ألف .. مستعشر ألف .. تلت
+
+285
+00:25:48,780 --> 00:25:52,060
+تلات و أربع تلات الصفر بيعك الدنيا على فكرة الصفر
+
+286
+00:25:52,060 --> 00:25:56,840
+اللي زيادة بيخرب الحل سعر البيع عشرة .. عشرة ..
+
+287
+00:25:56,840 --> 00:26:02,400
+عشرة .. عشرينطبعاً في حاجة عملها هو لإن هو مش كاتب
+
+288
+00:26:02,400 --> 00:26:05,520
+أيش الجدول هذا مجهول الهوية موازنة .. موازنة ..
+
+289
+00:26:05,520 --> 00:26:09,000
+موازنة .. موازنة .. موازنة .. موازنة .. موازنة ..
+
+290
+00:26:09,000 --> 00:26:09,080
+موازنة .. موازنة .. موازنة .. موازنة .. موازنة ..
+
+291
+00:26:09,080 --> 00:26:09,320
+موازنة .. موازنة .. موازنة .. موازنة .. موازنة ..
+
+292
+00:26:09,320 --> 00:26:10,620
+موازنة .. موازنة .. موازنة .. موازنة .. موازنة ..
+
+293
+00:26:10,620 --> 00:26:15,280
+موازنة .. موازنة .. موازنة .. موازنة .. موازنة ..
+
+294
+00:26:15,280 --> 00:26:26,740
+موازنة .. موازنة .. موازنة
+
+295
+00:26:26,740 --> 00:26:37,430
+.. موازنة .. موازشكرا يا auntie طبعا بالدولار ماشي
+
+296
+00:26:37,430 --> 00:26:40,110
+مين يطلع يجيب موازنة تكاليف الإدارية التابعة، نقدي
+
+297
+00:26:40,110 --> 00:26:45,350
+ودفتري، يلا يا آية العوضة إذا
+
+298
+00:26:45,350 --> 00:26:48,710
+ضربنا هذا في هذا في هذا فجيبنا هذا فأخدنا الدرجة
+
+299
+00:26:48,710 --> 00:26:53,350
+الكاملة على هؤلاء يلا يا و لا .. يلا يا آية شكرا
+
+300
+00:26:53,350 --> 00:26:53,590
+يا و لا
+
+301
+00:26:59,090 --> 00:27:05,450
+أهو ده معاكي محاضرة الموازنات كلها محاضرات اللي
+
+302
+00:27:05,450 --> 00:27:08,250
+بيبقى على الصبورة معاكي ولا لأ؟ ده شوفيوا أنتوا
+
+303
+00:27:08,250 --> 00:27:13,810
+ماتخفيش يعني مش هيتم ألقى القبض عليكي أنا عارف
+
+304
+00:27:13,810 --> 00:27:18,850
+ماخده بقالك معاكي
+
+305
+00:27:18,850 --> 00:27:23,910
+ولا لأ؟ مين معايا يا جماعة المحاضرات؟ ما شاء الله
+
+306
+00:27:30,530 --> 00:27:35,790
+ماشاء الله ساعة النبي ان شاء الله يعني بتكتبوا
+
+307
+00:27:35,790 --> 00:27:42,110
+على ال slide نفسه على ال slide نفسه يتم
+
+308
+00:27:42,110 --> 00:27:51,230
+التراكم لبدايته؟
+
+309
+00:27:51,230 --> 00:27:54,570
+عايزة اللي جابلها
+
+310
+00:27:59,310 --> 00:28:06,130
+طلعيها من العقل لو سمحت شكرا يا نسمة نعم
+
+311
+00:28:06,130 --> 00:28:12,890
+يا أنتي للفصل التالت اه الامتحان يا أخوات فقط صح و
+
+312
+00:28:12,890 --> 00:28:20,110
+غطو عملي للفصل التالت الامتحان مباشر أتوقع الجميع
+
+313
+00:28:22,800 --> 00:28:25,580
+أنا بعرفش أروح و أتحطط كل امتحانة تلات شباتة،
+
+314
+00:28:25,580 --> 00:28:28,000
+ماعرفش أشي عملتيها، فهو الامتحان السلم، تلاتة، هو
+
+315
+00:28:28,000 --> 00:28:32,740
+السلم أصلا، مافيش ممكنية تغيير، تلاتة، ماحنا حكينا
+
+316
+00:28:32,740 --> 00:28:36,760
+في الموضوع يوم الأربع، ماعرفش هو ليش صار هيك، لعله
+
+317
+00:28:36,760 --> 00:28:43,740
+خير، إذا تلات فصول الأولى، الامتحان فقط خمس عشر
+
+318
+00:28:43,740 --> 00:28:49,890
+عبارة صح وخطأ، والباقي عمليالامتحان مباشر و بسيط و
+
+319
+00:28:49,890 --> 00:28:54,750
+ان شاء الله الجميع يجيب الدرجة الكاملة، لا
+
+320
+00:28:54,750 --> 00:28:57,850
+الامتحان بسيط ان شاء الله، ان شاء الله يجيبوا
+
+321
+00:28:57,850 --> 00:29:06,750
+درجات عالية زي العلاقات العامة، أتوقع
+
+322
+00:29:06,750 --> 00:29:08,750
+611،
+
+323
+00:29:14,090 --> 00:29:17,570
+أنا بعرفش يا عمتي صعب إن احنا نقش الموضوع في تصوير
+
+324
+00:29:17,570 --> 00:29:21,070
+في
+
+325
+00:29:21,070 --> 00:29:24,150
+تصوير
+
+326
+00:29:24,150 --> 00:29:29,750
+طب
+
+327
+00:29:29,750 --> 00:29:36,150
+أتحلت و بصمت فهنعطيها الدرجة و بصمت فاهمين
+
+328
+00:29:36,150 --> 00:29:39,150
+أه؟ اللي عنده مشكلة يسأل الأستاذ آية
+
+329
+00:29:42,560 --> 00:29:52,060
+أه يا دالر خلّيكي معانا طبعا
+
+330
+00:29:52,060 --> 00:29:56,700
+أنا هقولك صح و لا غلط بصندوق برضه
+
+331
+00:29:56,700 --> 00:30:07,040
+فيا
+
+332
+00:30:07,040 --> 00:30:10,400
+السؤال أو السفسار إذا أن اليوم يا أسمعان المحاضرة
+
+333
+00:30:10,400 --> 00:30:15,510
+كانت مراجعةالمحاضرة كانت يا إسلام مراجعة على
+
+334
+00:30:15,510 --> 00:30:20,170
+الموازنات التشغيلية، يوم الإتنين إن شاء الله، إذا
+
+335
+00:30:20,170 --> 00:30:23,090
+ربنا أراد، راح نبدأ في حاجة جديدة، في أي سؤال أو
+
+336
+00:30:23,090 --> 00:30:26,870
+استفسار؟ طبعا بعد خلصوا امتحانات و تتحنونا، هنعمل
+
+337
+00:30:26,870 --> 00:30:30,070
+quiz في هذه المواضيع، يعطيكوا العافية
+
diff --git a/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/y6Q9291HQQQ_raw.srt b/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/y6Q9291HQQQ_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..e3a652b5c8689f098c33ca3119e4c9b7a2f077e1
--- /dev/null
+++ b/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/y6Q9291HQQQ_raw.srt
@@ -0,0 +1,1920 @@
+1
+00:00:20,860 --> 00:00:23,540
+أعوذ بالله السميع ليعلمنا الشيطان الرجيم بسم الله
+
+2
+00:00:23,540 --> 00:00:26,820
+الرحمن الرحيم الحمد لله والصلاة والسلام على
+
+3
+00:00:26,820 --> 00:00:30,780
+المصطفى الأمين سيدنا محمد وعلى آله ومن ساره على
+
+4
+00:00:30,780 --> 00:00:34,000
+درج بيحسين المدين بدا السلام عليكم ورحمة الله، كيف
+
+5
+00:00:34,000 --> 00:00:38,440
+حالكم؟ كيف أسبحتوا اليوم؟ كيف الجو معاكم ان شاء
+
+6
+00:00:38,440 --> 00:00:42,110
+الله منيح؟هنكمل مع بعضنا بدأنا الفصل الماضي أو
+
+7
+00:00:42,110 --> 00:00:45,090
+المحاضرة الماضية عن الرقابة الإدارية في ظل اللا
+
+8
+00:00:45,090 --> 00:00:48,830
+مركزية وأسعار التحويل قبل ما نحكي عن أنواع أسعار
+
+9
+00:00:48,830 --> 00:00:52,150
+التحويل بدنا نناجح مع بعض شو يعني أسعار التحويل
+
+10
+00:00:52,150 --> 00:01:03,130
+أسعار التحويل البساطة عندنا قسم مثلا التسويق وقسم
+
+11
+00:01:03,130 --> 00:01:11,370
+الإنتاج أثنين في نفس المؤسسةبصير بينهم عملية بيع و
+
+12
+00:01:11,370 --> 00:01:17,350
+شراء بيع لأو العكس بيع
+
+13
+00:01:17,350 --> 00:01:24,050
+شراء يعني قسم التسويق بدي أشتري من قسم الإنتاج في
+
+14
+00:01:24,050 --> 00:01:29,990
+نفس المؤسسة هان التسويق بيكون مشتري وإنتاج بائع
+
+15
+00:01:29,990 --> 00:01:35,930
+هدف قسم المشتري أو قسم التسويق أقل تكلفة أني أشتري
+
+16
+00:01:35,930 --> 00:01:40,630
+السلع بأقل تكلفة و أعلى جودةبينما البائع هدفه أنه
+
+17
+00:01:40,630 --> 00:01:45,630
+يبيعوا السلعة بأعلى إيراد يدعى الهدفين متعاكسين،
+
+18
+00:01:45,630 --> 00:01:52,650
+الهدفين أشمالهم متعاكسين مثلا عندنا كلية التجارة
+
+19
+00:01:52,650 --> 00:01:59,170
+قسم إدارة في الجامعة الإسلامية بدهم يشتروا شراء
+
+20
+00:01:59,170 --> 00:02:11,080
+قرطاسية من مكتبة الطالب أو قسم المشترياتمن قسم
+
+21
+00:02:11,080 --> 00:02:16,020
+المشتريات داخل
+
+22
+00:02:16,020 --> 00:02:19,680
+الجامعة قسم
+
+23
+00:02:19,680 --> 00:02:22,920
+الإدارة إذا أشترى من داخل الجامعة بنسميها أسعار
+
+24
+00:02:22,920 --> 00:02:29,900
+تحويل إذا من خارجها عمليت شراء عادي واضح ولا
+
+25
+00:02:29,900 --> 00:02:33,040
+عيدها؟ إذا الأسعار التحويل عملت زي مثلا ببساطة
+
+26
+00:02:33,040 --> 00:02:39,860
+الوالد عنده supermarketهل أشتري من عنده ولا نشتري
+
+27
+00:02:39,860 --> 00:02:43,960
+من مكان تاني؟ حاجة بنسميها سعار تحويل تعرضنا لها
+
+28
+00:02:43,960 --> 00:02:48,080
+المحادرة السابقة ما هي أنواع سعار التحويل؟ يعني
+
+29
+00:02:48,080 --> 00:02:51,020
+السعر اللي بنقلل فيه التكلفة للمشتري و بنرفع فيه
+
+30
+00:02:51,020 --> 00:02:55,080
+الإيراد للبائع، إيش أنواعهم؟ إما سعر السوق، رقم
+
+31
+00:02:55,080 --> 00:03:02,070
+واحد، سعر السوق التفاوضيأو سعر التحويل المبني على
+
+32
+00:03:02,070 --> 00:03:07,370
+التكلفة هذا أو سعر التحويل المزدوج تعالوا ناخدهم
+
+33
+00:03:07,370 --> 00:03:13,050
+واحد واحد ونشوف ما المقصود بسعر السوق؟ ببساطة يا
+
+34
+00:03:13,050 --> 00:03:17,810
+أخوات سعر السوق هو السعر المبني على الطلب والعرض
+
+35
+00:03:17,810 --> 00:03:25,530
+بمعنى يتم تحديد سعر السوق بناء على الطلب والعرض
+
+36
+00:03:25,530 --> 00:03:33,190
+للسلعةبانزل ع السوق بشوف بقدش المكاتب بتبيع السلع
+
+37
+00:03:33,190 --> 00:03:39,230
+هادي و برجع بحكي للجامعة أنا بديها بسعر السوق هو
+
+38
+00:03:39,230 --> 00:03:45,410
+أفضل سعر من أخواته الأربعة في حالة وجود منافسة و
+
+39
+00:03:45,410 --> 00:03:50,330
+أسعار إيش معلوم إذا لما يكون فيه منافسة بأنجح مع
+
+40
+00:03:50,330 --> 00:03:58,880
+سعر السوق إذا السؤال متى يفضل سعر السوقكسعر تحويل
+
+41
+00:03:58,880 --> 00:04:04,840
+وماعرفش معناه سعر التحويل في حالة وجود منافسة وفي
+
+42
+00:04:04,840 --> 00:04:09,460
+حالة لا سعر شمالها تكون معروف بمعنى الجلم هذا جديش
+
+43
+00:04:09,460 --> 00:04:13,160
+سعر في السوق بخمس شجرة باجي على الجامعة بقول بديها
+
+44
+00:04:13,160 --> 00:04:18,540
+بخمس شجرة بحكولي بستة بقولهم لأ انا بديها حسب سعر
+
+45
+00:04:18,540 --> 00:04:23,220
+الجاري في السوق اذا
+
+46
+00:04:26,200 --> 00:04:30,860
+عملية البيع والشراء بتتم داخل المؤسسة كأي عملية
+
+47
+00:04:30,860 --> 00:04:35,900
+بيع وشراء خارج المؤسسة السعر داخل الجامعة بختلفش
+
+48
+00:04:35,900 --> 00:04:42,600
+عنه خارج الجامعة هذا بنسميه سعر السوق طبعا هان
+
+49
+00:04:42,600 --> 00:04:48,160
+خلاص فيش إمكانية أن أحنا نقل و نفصل أو نتفاوض لإنه
+
+50
+00:04:48,160 --> 00:04:53,390
+أنا هكذا سعر السوق بنمشي العالموهذا الأمر لا يزعج
+
+51
+00:04:53,390 --> 00:04:56,510
+الإدارة العنية مدام أنه كل شيء تمام وفي اتفاق
+
+52
+00:04:56,510 --> 00:05:05,190
+وطاقة إنتاجية لكن سؤال بطرح نفسه علّلي صعوبة
+
+53
+00:05:05,190 --> 00:05:12,540
+الاعتماد على سعر السوقفي جميع الحالات طب بدأت
+
+54
+00:05:12,540 --> 00:05:15,860
+عندنا حاجة مريحانة أني أنزل على السوق و أجمع
+
+55
+00:05:15,860 --> 00:05:21,060
+معلومات و أشوف بقداش السلعب بتنبع و أجي أشري داخل
+
+56
+00:05:21,060 --> 00:05:25,640
+المؤسسة بنفس السعر طب احنا ليش قلنا كمان تلت أنواع
+
+57
+00:05:25,640 --> 00:05:31,900
+أسعار التحويل غير هذا بيحكي إن سعر التحويل لا يمكن
+
+58
+00:05:31,900 --> 00:05:34,800
+الاعتماد عليه في كل مرة
+
+59
+00:05:38,060 --> 00:05:42,520
+بحكينا من الصعب حين ما نعرفت سعر السلعة في السوق
+
+60
+00:05:42,520 --> 00:05:49,040
+خاصة لما تكون السلعة محتكرة لأن احنا شرطنا للبيع
+
+61
+00:05:49,040 --> 00:05:52,480
+في سعر الاعتماد على سعر السوق ان نكون في حالة
+
+62
+00:05:52,480 --> 00:05:57,300
+منافسة لأن العكس لما نكون في حالة الاحتقار سعر
+
+63
+00:05:57,300 --> 00:06:01,850
+السوق بالنسبة لسعار التحويل لا ينجحإذا ماذا لا
+
+64
+00:06:01,850 --> 00:06:06,530
+ينجح سعر السوق في حالة احتكار السلع أو عدم وجود
+
+65
+00:06:06,530 --> 00:06:11,330
+سلع متشابهة؟ ماذا ينجح في حالة وجود منافسة وفي
+
+66
+00:06:11,330 --> 00:06:17,090
+حالة توفر معلومات عن سعر السلع؟ واضحة ولا أعيدها؟
+
+67
+00:06:17,090 --> 00:06:22,790
+أعيدها؟ أعيدها تاني؟ أعيد ولا أكمل؟ إذا سعر السوق
+
+68
+00:06:22,790 --> 00:06:27,790
+بيخضع للطلب والعرض فقط النوع التاني من أسعار
+
+69
+00:06:27,790 --> 00:06:29,230
+التحويل زي ما توحكنا
+
+70
+00:06:37,810 --> 00:06:45,850
+سعر السوق التفاوض، سعر السوق التفاوض، إذا هذا
+
+71
+00:06:45,850 --> 00:06:51,550
+الاسم مكوّن من نقطين أو مصطلحين، سعر السوق معناه
+
+72
+00:06:51,550 --> 00:06:55,630
+السعر اللي في السوقالتفارض هي معناه في حالة أخد
+
+73
+00:06:55,630 --> 00:06:59,810
+وعطاء بين البائع والمشتري هناك حالة من الأخد
+
+74
+00:06:59,810 --> 00:07:04,290
+والعطاء بالنسبة للسعر بين البائع والمشتري نشوف ايش
+
+75
+00:07:04,290 --> 00:07:08,950
+كتب لنا فيه ضليلة مركزية يجب مش يفضّل أن يكون هناك
+
+76
+00:07:08,950 --> 00:07:12,490
+حرية لمراكز الاستثمار اللي بيع منتجاتها أو شرائها
+
+77
+00:07:12,490 --> 00:07:18,910
+بما يحقق منافع للطرفين من الطرفين عندنا البائع
+
+78
+00:07:18,910 --> 00:07:27,540
+مصلحته تكمن في زيادة الإيرادالمشتري مصلحته تكون في
+
+79
+00:07:27,540 --> 00:07:33,340
+تقليل التكاليف، إذا البائع يطمح لزيادة السعر،
+
+80
+00:07:33,340 --> 00:07:39,880
+بينما المشتري يطبخ لتقليل السعر، عندها خطوتين
+
+81
+00:07:39,880 --> 00:07:47,100
+بالنسبة لسعر السوق التفاوضي، واحد إذا خطوات سعر
+
+82
+00:07:47,100 --> 00:07:49,300
+السوق التفاوضي
+
+83
+00:07:52,770 --> 00:08:01,610
+واحد معرفة سعر الجهاز مثلا في السوق بصراحة الجهاز
+
+84
+00:08:01,610 --> 00:08:08,690
+بمواصفات 500$ على سبيل المثال اتنين بحمل السعر هذا
+
+85
+00:08:08,690 --> 00:08:15,380
+كمشتر باجي لمؤسستي و بعمل عملية تفاوتببدأ أنا
+
+86
+00:08:15,380 --> 00:08:20,240
+أحاول أقلل السعر هذا بصير عملية تفاوض عادية لحتى
+
+87
+00:08:20,240 --> 00:08:28,380
+نصل للخطوة التالتة لسعر متفق عليه لا يسبب خسارة
+
+88
+00:08:28,380 --> 00:08:42,720
+لأحد إذا سوق في طلب و عرض بحدد السعر بأعرفه بعد
+
+89
+00:08:42,720 --> 00:08:48,630
+هيك باجي علىمؤسستي بعمل
+
+90
+00:08:48,630 --> 00:08:58,690
+تفاوض أخر خطوة اللي هي عملية الاتفاق على سعر جيد
+
+91
+00:08:58,690 --> 00:09:03,770
+ممكن الجهاز يكون في السوق ب 500 أنا أجي على
+
+92
+00:09:03,770 --> 00:09:07,150
+المؤسسة و أتفاوض و الموضوع بحتاج إلى مهارات
+
+93
+00:09:07,150 --> 00:09:11,310
+التفاوض إذا لازم المشتري و البايع يكون عنده مهارات
+
+94
+00:09:11,310 --> 00:09:16,430
+التفاوضفبقى أشتري الجهاز من داخل المؤسسة بـ450
+
+95
+00:09:16,430 --> 00:09:22,430
+دولار، مش بـ500، هيك لا بيكون المشتري خسرا ولا
+
+96
+00:09:22,430 --> 00:09:28,030
+البائع يشعر بأضله، إذن سعر السوق التفاوض يعرف أن
+
+97
+00:09:28,030 --> 00:09:32,770
+هو نفسه سعر السوق، ولكن في كمان خطوة زيادة إنه بعد
+
+98
+00:09:32,770 --> 00:09:37,010
+ما أعرف السعر لازم أعمل عملية تفاوض عليه، بلكن خفف
+
+99
+00:09:37,010 --> 00:09:39,870
+شوية من تكاليفنا كمشتري
+
+100
+00:09:43,050 --> 00:09:50,350
+أدكري عيوب سعر السوق التفاوضي إذا عندي سؤال أدكري
+
+101
+00:09:50,350 --> 00:09:55,990
+عيوب سعر السوق التفاوضي إذا الكلام على أرض الواقع
+
+102
+00:09:55,990 --> 00:10:00,010
+مش من البساطة اللي إحنا بنحكيه بيحكيلي سعر السوق
+
+103
+00:10:00,010 --> 00:10:03,750
+التفاوض أني أعرف سعر السلع خارج المؤسسة و أرجع
+
+104
+00:10:03,750 --> 00:10:09,670
+أتفاوض العيوب ما هي؟ عملية الأخذ والعطا والاتفاق
+
+105
+00:10:09,670 --> 00:10:14,210
+على السعر هتاخد منها وقت طويلإذا مختلف عن النوع
+
+106
+00:10:14,210 --> 00:10:19,070
+الأول من أنواع السعر التحويل هو سعر السوق في
+
+107
+00:10:19,070 --> 00:10:22,070
+المرحلة الأولى كنت عارف السعر واجه اتفاوض الماشي
+
+108
+00:10:22,070 --> 00:10:25,510
+داخل المؤسسة في المرحلة التانية لازم نتفاوض
+
+109
+00:10:25,510 --> 00:10:32,750
+بيحكيلي التفاوض بياخد رجل طويل من البائع والمجتمع
+
+110
+00:10:32,750 --> 00:10:36,930
+انا
+
+111
+00:10:36,930 --> 00:10:41,290
+حاولت اتفاوض معه دههو ده هي القسم البائع في
+
+112
+00:10:41,290 --> 00:10:46,710
+المؤسسة و أنا القسم المشتري فلمّا أجينا نتفاوض
+
+113
+00:10:46,710 --> 00:10:55,890
+فشلنا فروحت أنا خارج المؤسسة لجيت بائع تاني أعطاني
+
+114
+00:10:55,890 --> 00:11:00,350
+السعر اللي أنا عايزاه إذا رقم اتنين في حالة فشلنا
+
+115
+00:11:00,350 --> 00:11:04,530
+في التفاوض مع القسم البائع داخل المؤسسة كمشترين
+
+116
+00:11:04,530 --> 00:11:09,930
+نلجأ للسوق الخارجيفهيك أموال المؤسسة هتروح للناس
+
+117
+00:11:09,930 --> 00:11:14,330
+خارج المؤسسة مما يقلل ال main أرباح من هدا اللي هي
+
+118
+00:11:14,330 --> 00:11:20,450
+الطرف البائع أعيد هذه تانية إذا المشكلة التانية في
+
+119
+00:11:20,450 --> 00:11:26,270
+سعر السوق التفاوضي أنه لو أنا المشتري وزمتكوا هدا
+
+120
+00:11:26,270 --> 00:11:32,950
+البائع من أشتري منها أنا قرطصي على سبيل المثالف
+
+121
+00:11:32,950 --> 00:11:35,950
+الخطوة الأولى رحت على السوق و نزلت عليه شوفت مجدش
+
+122
+00:11:35,950 --> 00:11:39,730
+أسعار الشغلات اللى أنا عايزاها و إجيت على الجامعة
+
+123
+00:11:39,730 --> 00:11:44,910
+بتفاوض معاه ده تفاوضنا فشر ماوصلناش لسعر متفق عليه
+
+124
+00:11:44,910 --> 00:11:49,310
+فهملت نفسي و رجعت على السوق تلقيت باقعين أخرين
+
+125
+00:11:49,310 --> 00:11:54,950
+أعطوني السلعة نفسها بنفس الجودة بسعر أقلأيه
+
+126
+00:11:54,950 --> 00:11:58,130
+كمشتغر؟ مش مشكلة، بس وين المشكلة؟ المشكلة عند هدى،
+
+127
+00:11:58,130 --> 00:12:01,850
+اللي هي البائع، وين مشكلة هدى؟ إن الأرباح اللي ..
+
+128
+00:12:01,850 --> 00:12:06,070
+أو السر الأموال اللي أنا دفعتها للطرف الخارجي،
+
+129
+00:12:06,070 --> 00:12:11,000
+راحت على قسم البائع داخل إيش؟ داخل المؤسسةمن
+
+130
+00:12:11,000 --> 00:12:14,640
+عيوبها كمان أن بعض الأوقات بيكونش فيه الطاقة غير
+
+131
+00:12:14,640 --> 00:12:18,480
+مستغلة، معناه أن المؤسسة مش بتشتغل بكامل طاقتها،
+
+132
+00:12:18,480 --> 00:12:23,420
+اللي هي الآلات والبشر مش شغلوش كتير، فممكن تقلل
+
+133
+00:12:23,420 --> 00:12:29,440
+السعر لتفادي الخسارة إن مش دايما التفاوض بيكون
+
+134
+00:12:29,440 --> 00:12:34,180
+لصالح المؤسسة، ممكن يكون التفاوض لحتى أقل الخسارة
+
+135
+00:12:34,180 --> 00:12:35,640
+من المؤسسة
+
+136
+00:12:37,480 --> 00:12:42,220
+طب إيش نسوي؟ بحكينا عشان نحل الـ 2 و 3 اللي هي أنا
+
+137
+00:12:42,220 --> 00:12:45,340
+بطلع بأموال الـ money أصلا خارجها أو ممكن البائع
+
+138
+00:12:45,340 --> 00:12:49,920
+يتهاود معايا علشان يقلل الخسارة إما نتفاوت على سعر
+
+139
+00:12:49,920 --> 00:12:54,180
+السوق أو نبيع بسعر السوق و خلاص أو أنه تيجي
+
+140
+00:12:54,180 --> 00:12:59,700
+الإدارة العليا تتدخل كيف الإدارة العليا تتدخل؟
+
+141
+00:12:59,700 --> 00:13:06,360
+إنها تضع سياسات تجبرأي مشتري بشراء السلعة من
+
+142
+00:13:06,360 --> 00:13:12,980
+داخلها سواء كان السعر أقل أو أعلى من سعر السوق إذن
+
+143
+00:13:12,980 --> 00:13:16,820
+كيف ممكن نحل المشاكل المكتوبة على الصابورة في
+
+144
+00:13:16,820 --> 00:13:22,020
+التفاوض؟ إما نتفاوض على سعر السوق وخلاص أو وهذا
+
+145
+00:13:22,020 --> 00:13:26,980
+اللي بيحصل أصلا إن المؤسسة تضع سياسة يمنع منع
+
+146
+00:13:26,980 --> 00:13:32,260
+انباتا .. انباتا عفوا أيها الموظفينمن شراء سلعة من
+
+147
+00:13:32,260 --> 00:13:38,680
+خارج المؤسسة أيًا كان السعر يعني الجهاز هذا داخل
+
+148
+00:13:38,680 --> 00:13:43,420
+المؤسسة ب 100 دولار خارجها ب 80 دولار طيب ممنون
+
+149
+00:13:43,420 --> 00:13:48,420
+دوا في العشرين ممنون لأن أنا داخل المؤسسة هذا
+
+150
+00:13:48,420 --> 00:13:52,820
+المقصود بأن تقوم الإدارة العليا بالتدخل أو فرق
+
+151
+00:13:52,820 --> 00:13:56,820
+التسعير إذا ما تاني قد كوريا غدير سعر السوق
+
+152
+00:13:56,820 --> 00:14:01,920
+التفارضي زي ما حكت زينتكواأو عرفة نذكر عيوبها تاخد
+
+153
+00:14:01,920 --> 00:14:06,900
+وقت طويل ممكن الأموال تخرج خارج المؤسسة ممكن تكون
+
+154
+00:14:06,900 --> 00:14:11,160
+عملية التهاون في التسعير بسبب الخسارة عشان هيك
+
+155
+00:14:11,160 --> 00:14:14,720
+بنحل المشاكل هذه إما عن طريق اللي بيحصل فرض سياسات
+
+156
+00:14:14,720 --> 00:14:17,820
+من قبل الإدارة العليا أو عن طريق التفاوض على سعر
+
+157
+00:14:17,820 --> 00:14:23,400
+السوق واضحة النقطة هذه ولا أعيدها؟ أعيدها تاني؟
+
+158
+00:14:23,400 --> 00:14:29,130
+أعيدها؟ ماشيالنوع التالت من أنواع التسعير زي ما
+
+159
+00:14:29,130 --> 00:14:34,490
+حكينا كانوا أربع نرجع تاني كانوا أربع في الرسمة
+
+160
+00:14:34,490 --> 00:14:38,530
+سعر السوق شرحناه بناء على طلبه العرض ومافي مشاكل
+
+161
+00:14:38,530 --> 00:14:42,790
+لكن مشكلته أنه هو بنجاح شغل في حالة المنافسة فقط
+
+162
+00:14:42,790 --> 00:14:48,110
+الاحتكار بيفشل اتنين سعر السوق التفاوضي هو نفسه
+
+163
+00:14:48,110 --> 00:14:51,290
+سعر السوق لكن بصير تفاوض واستعرضناله بالتفصيل
+
+164
+00:14:51,290 --> 00:14:56,190
+تلاتة سعر التحويل المبني على التكلفة
+
+165
+00:14:58,440 --> 00:15:02,680
+سؤال بطرح نفسه أخدنا في الفصل التاني في هذه المادة
+
+166
+00:15:02,680 --> 00:15:09,360
+تكليف وسلوكها بالتفصيل مين اذكرنا بتعريف التكليف،
+
+167
+00:15:09,360 --> 00:15:14,940
+عفوا، التكليف أو ال cost، فضلي آية إذن التكلفة هي
+
+168
+00:15:14,940 --> 00:15:18,400
+التضحية بمواد المؤسسة أو بمواد معينة لحصولها على
+
+169
+00:15:18,400 --> 00:15:22,160
+هدفها، زي ما أخدنا مع بعض التكلفة نوعية، تكلفة
+
+170
+00:15:22,160 --> 00:15:27,770
+متغيرة وتكلفةاشتكلفة تابعةأو تكلفة الكلية أو تكلفة
+
+171
+00:15:27,770 --> 00:15:30,990
+المتغيرة عفوا تكلفة الكلية هي التكليف التابعة زي
+
+172
+00:15:30,990 --> 00:15:34,990
+التكليف المتغيرة التكليف المتغيرة هي فقط التكليف
+
+173
+00:15:34,990 --> 00:15:43,520
+المتغيرة زي الأجور حادث زي الرواتب زي الأجورأخدنا
+
+174
+00:15:43,520 --> 00:15:47,280
+مع بعض كمان التكليف التابت لاتتغير بحجم النشاط، لا
+
+175
+00:15:47,280 --> 00:15:50,540
+تتأثر زي راتب المدير، مالوش دعوة، التكليف المتغير
+
+176
+00:15:50,540 --> 00:15:55,420
+إلها علاقة ترضية مع حجم النشاط، أخدنا زي الأجور،
+
+177
+00:15:55,420 --> 00:15:59,200
+علاقة ترضية، الكلام هذا فصلنا فيه تعالوا نشوف مع
+
+178
+00:15:59,200 --> 00:16:04,520
+بعض أسعار التحويل الآن، المبنية على التكلفةسؤال
+
+179
+00:16:04,520 --> 00:16:09,880
+متى تستعمل التكلفة الكلية؟ إذا متى ألجأ لسعر
+
+180
+00:16:09,880 --> 00:16:14,040
+التحويل المبني على التكاليف التابعة والتكاليف
+
+181
+00:16:14,040 --> 00:16:20,540
+المتغيرة، اللي هي التكاليف الكلية؟ بيحكيلي عند أدم
+
+182
+00:16:20,540 --> 00:16:25,660
+توفر مقاييس لأسعار السوق للمنتج، إذا لما يكون صعب
+
+183
+00:16:25,660 --> 00:16:32,550
+أني أوفر أسعار معلومات عن أسعار السوقلمنتج معين
+
+184
+00:16:32,550 --> 00:16:37,590
+ممكن أرجع للتسعير على أساس إيش التكلفة معادلة
+
+185
+00:16:37,590 --> 00:16:44,250
+السعر أخدتها في المستوى الأول السعر يساوي التكلفة
+
+186
+00:16:44,250 --> 00:16:51,330
+زائد همش القنعة إذا أنا مش قاعدة أوصل لسعر السوق
+
+187
+00:16:51,330 --> 00:16:56,790
+لسبب معين ممكن أحسبها عن طريق المعادلةسؤال ادكر
+
+188
+00:16:56,790 --> 00:17:01,990
+مزايا التكاليف الكلية او ادكر مزايا سعر التحويل
+
+189
+00:17:01,990 --> 00:17:06,070
+اللي نبني على أساس التكاليف الكلية عندنا تلات
+
+190
+00:17:06,070 --> 00:17:11,490
+مزايا، شوفهم مع بعض أول شيء، التكاليف الكلية بتكون
+
+191
+00:17:11,490 --> 00:17:16,690
+معلومة للشركة ضمن حساباتها وضمن إيش؟ ضمن موازنتها،
+
+192
+00:17:16,690 --> 00:17:19,190
+لأن أول حاجة والله التكاليف الكلية وبياناتنا
+
+193
+00:17:19,190 --> 00:17:25,270
+وحساباتنا بتكون معروفة بالنسبة إلينا ثانيالقسم
+
+194
+00:17:25,270 --> 00:17:28,730
+البائع ممكن يغطي تكاليفه عن طريق المعادلة هذه
+
+195
+00:17:28,730 --> 00:17:36,030
+التكلفة زاداش زاد هامش الربح إذن يستطيع قسم البائع
+
+196
+00:17:36,030 --> 00:17:40,910
+بناء على هذه المعادلة أن يقطي جميع تكاليفه ثلاثة
+
+197
+00:17:41,720 --> 00:17:45,120
+بحكينا التكاليف الكلي أكتر عدالة من التكاليف الاش
+
+198
+00:17:45,120 --> 00:17:48,700
+التكاليف المتغيرة لأنه في عندنا تكاليف وسميناها
+
+199
+00:17:48,700 --> 00:17:53,180
+التكاليف المختلطة في منها جزء متغير و جزء اشمال و
+
+200
+00:17:53,180 --> 00:18:00,840
+جزء تابت لذا مرة تانية ادخلي مزايا total cost أو
+
+201
+00:18:00,840 --> 00:18:09,100
+التكلفة الكلية في حال استخدامها للتسعير التحوي أو
+
+202
+00:18:09,100 --> 00:18:14,720
+كسعر تحويبتكون معلومة بتخلي القسم البائع يحسب جميع
+
+203
+00:18:14,720 --> 00:18:18,520
+تكاليفه كمان هنشربه هي أكتر من عدالة من التكاليف
+
+204
+00:18:18,520 --> 00:18:21,180
+الكلية .. متعفن من التكاليف .. التكاليف الكلية
+
+205
+00:18:21,180 --> 00:18:24,800
+أكتر عدالة من التكاليف المتغيرة لأن هناك تكاليف لا
+
+206
+00:18:24,800 --> 00:18:32,120
+تصنف لا تابعة ولا متغيرة أعيدها تاني ولا واضحة؟
+
+207
+00:18:32,120 --> 00:18:39,410
+طيب ما هي عيوبها؟ ما هي عيوبها؟بحكينا أول حاجة من
+
+208
+00:18:39,410 --> 00:18:44,690
+الممكن أن لا تؤدي إلى تعظيم أرباح البائع لسه أول
+
+209
+00:18:44,690 --> 00:18:48,490
+محاضرة شرحنا المشترك بده يشتري السلع بجودة عالية و
+
+210
+00:18:48,490 --> 00:18:53,190
+أقل تكاليف والبائع بده يبيع السلع بأعلى الأرباح
+
+211
+00:18:53,190 --> 00:18:56,990
+إذا أن رقم 1 بتكون القسم البائع فقط من الممكن أن
+
+212
+00:18:56,990 --> 00:19:01,880
+لا تؤدي إلى تعظيم الأرباحبعض الأوقات لازم أظل
+
+213
+00:19:01,880 --> 00:19:07,280
+أستنى بس نخلص الإنتاج لحتى نقدر نسعر لأنه محتاج
+
+214
+00:19:07,280 --> 00:19:14,280
+التكاليف الفعلي هذا بترتب عليه القسم المشتري بقدرش
+
+215
+00:19:14,280 --> 00:19:19,800
+يخطط عفوا
+
+216
+00:19:19,800 --> 00:19:25,140
+القسم المشتري بقدرش يخطط غير لما رقم 2 يصير ايش
+
+217
+00:19:25,140 --> 00:19:31,040
+رقم 2 أمامنا على السبورة؟ ان احنا ننهي الإنتاجرقم
+
+218
+00:19:31,040 --> 00:19:35,340
+4 بما أن المعادلة هيها التكاليف الكلية زاد همش
+
+219
+00:19:35,340 --> 00:19:39,820
+الربح بس مافيش حاجة بتخلي القسم البائع يراقب
+
+220
+00:19:39,820 --> 00:19:44,320
+تكاليفه لأنه بيجمعها كلها فبيكون عنده عدم دقة في
+
+221
+00:19:44,320 --> 00:19:48,900
+الحساب، هذا إيش بترتب عليه؟ لو القسم البائع حسب
+
+222
+00:19:48,900 --> 00:19:54,900
+التكاليف بشكل خاطئ، الأمر هذا هيتسلب لقسم المشتري،
+
+223
+00:19:54,900 --> 00:20:04,050
+إذا أنا كقسم مشتريفأستنى القسم البائع يبعتلي
+
+224
+00:20:04,050 --> 00:20:11,370
+تكاليفه بناء عليها أنا بأخطط للشراء منه في الحالة
+
+225
+00:20:11,370 --> 00:20:17,050
+هذه إذا تم حساب التكاليف بشكل خاطئ و غير دقيق من
+
+226
+00:20:17,050 --> 00:20:24,030
+قبل قسم البائع اللي هو هدا أنا كمشتري هاعتمد على
+
+227
+00:20:24,030 --> 00:20:29,140
+الخطأ في الحسابإذن الخلل اللي صار في القسم البائع
+
+228
+00:20:29,140 --> 00:20:34,580
+انتقل بشكل مباشر للقسم إيش للقسم المشترك إذن خدي
+
+229
+00:20:34,580 --> 00:20:38,720
+بالك اتنين و تلاتة و أربع مرتبطين في بعض اتنين
+
+230
+00:20:38,720 --> 00:20:42,160
+مابنقدرش نساعد بنالنا التكلفة الكلية إلا لما نخلص
+
+231
+00:20:42,160 --> 00:20:46,000
+الإنتاج بترتب عليه إن القسم المشترك بضال يستنى بس
+
+232
+00:20:46,000 --> 00:20:49,940
+الإنتاج يخلص بترتب عليه إن قسم البائع بدلها تكليف
+
+233
+00:20:49,940 --> 00:20:54,380
+كلية بيكونش دقيق في حساب التكلفةبترتب عليه عدم
+
+234
+00:20:54,380 --> 00:20:58,340
+موجود كفارة هان ممكن تمرير القسم البقع يمكن أنه ما
+
+235
+00:20:58,340 --> 00:21:02,820
+غيرها عدم الكفارة هذه القسم الاشهر المشترك طب ما
+
+236
+00:21:02,820 --> 00:21:06,220
+هو الحال في هذه الحالة؟ أنه احنا بلاش نسعر على
+
+237
+00:21:06,220 --> 00:21:10,080
+التكاليف الكلية الفعلية بنسعر على التكاليف المعين
+
+238
+00:21:10,080 --> 00:21:12,560
+اللي هي المخططة اللي احنا خدناها الفصل الماضي اللي
+
+239
+00:21:12,560 --> 00:21:16,850
+هي الموازنات المدنيةإذن لعلاج مشكلة التسعير على
+
+240
+00:21:16,850 --> 00:21:20,970
+أساس التكاليف الكلية الأربع اللي أمامنا أو الخمسة
+
+241
+00:21:20,970 --> 00:21:27,170
+ننصح بالاعتماد على التكاليف الميارية شو معنى
+
+242
+00:21:27,170 --> 00:21:31,650
+تكاليف ميارية؟ تكاليف مخططة شو معنى مخططة؟ تقديرية
+
+243
+00:21:31,650 --> 00:21:34,190
+نعيد تاني
+
+244
+00:21:41,300 --> 00:21:44,680
+إذن أخدنا التكلفة الكلية، دي التكليف التابدة زاد
+
+245
+00:21:44,680 --> 00:21:50,040
+ما تغيرها، مات بنرجعلها، إيش مزاياها التلاتة، وإيش
+
+246
+00:21:50,040 --> 00:21:54,340
+عيوبها الخمسة، وكيف ممكن أقدملها حل مضبط، فيهم أي
+
+247
+00:21:54,340 --> 00:22:00,200
+سؤال هدول؟ في أي سؤال أو استفسار؟ النوع التالي من
+
+248
+00:22:00,200 --> 00:22:05,210
+أنواع أسعار التحويلالمبنية التكلفة اللي هي
+
+249
+00:22:05,210 --> 00:22:10,730
+التكاليف المتغيرة التكاليف المتغيرة سؤال يطرح نفسه
+
+250
+00:22:10,730 --> 00:22:20,370
+متى نرجع في أسعار التحويل للتكلفة المتغيرة عند
+
+251
+00:22:20,370 --> 00:22:24,930
+أدم وجود طاقة غير مستغلة أو عفوا عند وجود طاقة غير
+
+252
+00:22:24,930 --> 00:22:29,260
+مستغلة مافيش أدمإيش يعني الطاقة غير مستغلة؟ في
+
+253
+00:22:29,260 --> 00:22:32,120
+عندنا عمال قاعدين فيهش شغل، فيه آلات بتشتغلش،
+
+254
+00:22:32,120 --> 00:22:35,320
+واقفة، هذه بيسميها طاقة غير إيش؟ غير مستغلة
+
+255
+00:22:35,320 --> 00:22:41,200
+استخدام الطاقة هذه ممكن .. يعني الألات هذه إذا
+
+256
+00:22:41,200 --> 00:22:45,920
+بينفع أستخدمها في صناعة السلع اللي المشتري بدي
+
+257
+00:22:45,920 --> 00:22:52,460
+يشتريه إذن، متدرجة للتكليف المتغيرة فيها سعر
+
+258
+00:22:52,460 --> 00:22:59,030
+التحويللما يكون عندنا طاقة غير مستغلة في قسم،
+
+259
+00:22:59,030 --> 00:23:05,130
+فممكن نستخدمها لحتى ننتج السلع للقسم المشتري داخل
+
+260
+00:23:05,130 --> 00:23:13,270
+المؤسسة اللي بيطلبها ما هي عيوبها؟ ده مرة تانية،
+
+261
+00:23:13,270 --> 00:23:16,720
+واكتشف إن الجهلها في حالة وجود طاقة غير مستغلةطيب
+
+262
+00:23:16,720 --> 00:23:20,560
+إيش يعني؟ يعني إنه في عندنا إحدى الأقسام في عنده
+
+263
+00:23:20,560 --> 00:23:24,300
+آلات وموظفين مانهم الشغل فبنجيبهم و بنشغلهم بطريقة
+
+264
+00:23:24,300 --> 00:23:30,080
+معينة لحتى ينجوء السلعة اللي طالبها القسم المشتري
+
+265
+00:23:30,080 --> 00:23:37,120
+وبناء على التكيف المتغيرة أنا بعمل سعر للمشتري
+
+266
+00:23:37,120 --> 00:23:43,800
+والبقاعي سؤال بطرح نفسه بقوة أذكري عيوببسعر
+
+267
+00:23:43,800 --> 00:23:49,300
+التحويل المبني على التكلفة المتغيرة فيحنا يا أخوات
+
+268
+00:23:49,300 --> 00:23:55,780
+أربع عيوب نشوفهم مع بعض أخدنا في إحدى المحاضرات أن
+
+269
+00:23:55,780 --> 00:24:02,540
+التكليف المتغيرة تتغير للإجمالي وتكون تابتة للوحدة
+
+270
+00:24:02,540 --> 00:24:08,440
+ماشي، إذا التكلفة بيحكي أن التكلفة المتغيرة بتكون
+
+271
+00:24:08,440 --> 00:24:11,800
+تابتة في مدى معين وبعدين بتبطل تابتها، ده ممكن
+
+272
+00:24:11,800 --> 00:24:15,090
+يسببلي مشكلةإذا النقل مواحد أتكلم في المتغيرات
+
+273
+00:24:15,090 --> 00:24:18,130
+بتكون تابعة فقط على متحاد معين بعد هيك بالزي ده دي
+
+274
+00:24:18,130 --> 00:24:25,910
+في حداتها مشكلة اتنين لسه قبل شوية حكينا أنه عشان
+
+275
+00:24:25,910 --> 00:24:30,010
+أستخدمها لازم يكون عندي طاقة فائدة ليه الطاقة غير
+
+276
+00:24:30,010 --> 00:24:34,430
+مستغلة بعض الأوقات القسم الباع بيفكر طب بدل أن
+
+277
+00:24:34,430 --> 00:24:37,910
+عندي طاقة فائدة ليش مستخدمها في إنتاج السلة و
+
+278
+00:24:37,910 --> 00:24:42,840
+أبيعها خارج المؤسسة؟ ليش نبيعها داخل المؤسسة؟إذا
+
+279
+00:24:42,840 --> 00:24:46,740
+رقم اتنين بما أنه عندي آلات فاضية غير شغالة
+
+280
+00:24:46,740 --> 00:24:51,400
+وموظفين ما لهم الشغل ليش ما نستغلهم لمصلحة المؤسسة
+
+281
+00:24:51,400 --> 00:24:58,240
+وذلك بإنتاج منتجات وبيعها خارج المؤسسة بأسعار أعلى
+
+282
+00:24:58,240 --> 00:25:03,580
+هذه فكرة واردة ومش خارقة رقم تلاتة بعض اللوقات
+
+283
+00:25:03,580 --> 00:25:09,580
+بيكون صعب نقيم إنجاز مديري الأقسامهذه بتشبه اللي
+
+284
+00:25:09,580 --> 00:25:13,300
+توشرحناها إن لو في عندنا عدم كفاءة في حساب
+
+285
+00:25:13,300 --> 00:25:16,600
+التكاليف للقسم البارح ينتقل directly للقسم المين
+
+286
+00:25:16,600 --> 00:25:28,360
+للقسم المشتري واضحة للي عيدها رقم أربعة صعوبة
+
+287
+00:25:28,360 --> 00:25:34,240
+مقارنة نجاحمدراء الأقسام اللي بيشتروا من داخل
+
+288
+00:25:34,240 --> 00:25:37,880
+الشركة مع مدراء الأقسام اللي بيشتروا من خارجها،
+
+289
+00:25:37,880 --> 00:25:40,620
+مين عنده كفاءة أكتر، بحيث لما تعتمدي على التكلفة
+
+290
+00:25:40,620 --> 00:25:45,320
+المتغيرة، لأ بيكون صعب نعرف مين الكفاءة اللي أعلى،
+
+291
+00:25:45,320 --> 00:25:49,480
+قائلة تانية، ما هي عيوب التكلفة المتغيرة؟ رقم واحد
+
+292
+00:25:50,170 --> 00:25:54,170
+التكلفة المتغيرة للوحدة تابعة لكن مش في جميع
+
+293
+00:25:54,170 --> 00:25:57,890
+الكميات في عند مدر معين بعدين بصي المتغيرة هذه في
+
+294
+00:25:57,890 --> 00:26:02,970
+حداتها مشكلة أن هي حدد بدقة التكلفة المتغيرة تاني
+
+295
+00:26:02,970 --> 00:26:08,050
+ممكن القسم البائع يفكر هيك تفكير تجاري بحت أنه أنا
+
+296
+00:26:08,050 --> 00:26:12,490
+بدل عندي آلات بتشتغلش في المؤسسة و عمال جاعدين طب
+
+297
+00:26:12,490 --> 00:26:15,550
+احنا ليش ما نعمل منتجات و نبيعها خارج المؤسسة أكتر
+
+298
+00:26:15,550 --> 00:26:20,540
+أرباحا و هذا مش غلطتلاتة صعوبة تقييم إنجاز مدراء
+
+299
+00:26:20,540 --> 00:26:23,120
+الأقسام هذه كمشروع شرحناها في التكاريف الكلية لو
+
+300
+00:26:23,120 --> 00:26:27,480
+كان القسم البائغ ماعندوش كفاءة في حساب إيه الأسعار
+
+301
+00:26:27,480 --> 00:26:31,500
+هيترتب عليه انتقال لعدم الكفاءة هذه للقسم المشترك
+
+302
+00:26:31,500 --> 00:26:40,400
+رقم أربعة عند وجود تقري .. عفوا صعوبة مقارنة إنجاز
+
+303
+00:26:40,400 --> 00:26:46,540
+مدراء الأقساماللي بيشتروا من داخل المؤسسة مع إنجاز
+
+304
+00:26:46,540 --> 00:26:51,500
+مدراء الأقسم اللي بيشتروا من خارجه ممكن يكون اللي
+
+305
+00:26:51,500 --> 00:26:55,020
+من الداخل أفضل وممكن يكون من الخارج أفضل اعتمادي
+
+306
+00:26:55,020 --> 00:26:59,400
+على التكلفة المتغيرة في التسعير بسببلي هذه المشكلة
+
+307
+00:26:59,400 --> 00:27:03,600
+التكلفة
+
+308
+00:27:03,600 --> 00:27:06,760
+المتغيرة والفرصة البديلة أكيد جميعكوا عارفة إيش
+
+309
+00:27:06,760 --> 00:27:12,400
+معناها فرصة بديلةبحكينا بعض الأوقات إحنا منحدد سعر
+
+310
+00:27:12,400 --> 00:27:14,780
+التحويل مازلنا في سعر التحويل على أساس التكلف وما
+
+311
+00:27:14,780 --> 00:27:19,920
+طلعناش منه قد يتم تحديد سعر التحويل حسب التكلف
+
+312
+00:27:19,920 --> 00:27:24,180
+المتغير للوحدة الواحدة زائد العقد الحد اللي هو
+
+313
+00:27:24,180 --> 00:27:30,180
+الربح المفقود للمركز محول منه نتيجة عدم بيع المنتج
+
+314
+00:27:30,180 --> 00:27:39,940
+للخروج وتحويله بالداخل عيدة كيف ممكن أوقف الشرح
+
+315
+00:27:57,690 --> 00:28:00,030
+ماهو ال LCD؟ لا يوجد ولا حاجة
+
+316
+00:28:40,820 --> 00:28:44,040
+أبدأ؟ أكمل يعني؟
+
+317
+00:28:59,790 --> 00:29:03,750
+إذن يا أخوات كيف ممكن نحل مشكلة السعر التحويل
+
+318
+00:29:03,750 --> 00:29:07,490
+المبني على التكلفة المتغيرة بحكيلي عن طريق تكلفة
+
+319
+00:29:07,490 --> 00:29:12,310
+الفرصة البديلية بشكل أسهل ممكن أقول سعر التحويل
+
+320
+00:29:12,310 --> 00:29:17,150
+بساوى هان خلتنا بس نغير اللون عشان ما تلخبطش نحن
+
+321
+00:29:17,150 --> 00:29:21,390
+ال slide بساوى التكلفة المتغيرة للوحدة اللي احنا
+
+322
+00:29:21,390 --> 00:29:31,550
+أخدناها قبل هيك U V Cost أو V VCUزائد الربح
+
+323
+00:29:31,550 --> 00:29:41,950
+المتوقع في حالة بيع المنتج لخارج المؤسسة اللي هي
+
+324
+00:29:41,950 --> 00:29:46,270
+الفرصة البديلة يعني لو أنا المنتج شبعي مابعتوش
+
+325
+00:29:46,270 --> 00:29:49,110
+داخل المؤسسة كان ممكن نبيعه خارج المؤسسة وبسعر
+
+326
+00:29:49,110 --> 00:29:53,610
+أعلى يعني بربح أعلى بس عشان نبعناها داخل المؤسسة
+
+327
+00:29:53,610 --> 00:29:59,640
+صار عندي حاجة اسمها الفرصة البديلةبحكينا من وشة
+
+328
+00:29:59,640 --> 00:30:03,340
+نظر اقتصادية هد تعتبر مقياس سليم لسعر إيش التحويل
+
+329
+00:30:03,340 --> 00:30:06,860
+المبني على التكلفة من وشة نظر الاقتصادي فده بنعيد
+
+330
+00:30:06,860 --> 00:30:12,180
+تاني كيف يتم تحليل بتحققفه كيف يتم حل مشاكل التكلف
+
+331
+00:30:12,180 --> 00:30:16,080
+المتغير اللي توصت على دنها مع بعض عن طريق المعادلة
+
+332
+00:30:16,080 --> 00:30:18,760
+التالية سعر التحويل المبني على التكلف المتغير
+
+333
+00:30:18,760 --> 00:30:25,260
+حساوى التكلف المتغير الوحدة زائد الربح المتوقعفي
+
+334
+00:30:25,260 --> 00:30:30,060
+حالة بيع السلعة خارج المؤسسة بنحسب الأثنين و بنحدد
+
+335
+00:30:30,060 --> 00:30:37,320
+السعر واضحة ولا عيدها؟ عيدها تاني؟ عيدها ولا
+
+336
+00:30:37,320 --> 00:30:46,580
+واضحة؟ في أي مشكلة لغاية الآن؟ في أي مشكلة؟
+
+337
+00:30:46,580 --> 00:30:50,500
+أخر حاجة في أنواع التسعير، نرجع لهم تاني
+
+338
+00:30:53,180 --> 00:30:57,020
+نذاكر مع بعض إيه شرحنا أول محاضرة قولنا أنواع
+
+339
+00:30:57,020 --> 00:31:01,760
+التسيير أربع أخدنا لغاية الآن تلاتة سعر السوق، سعر
+
+340
+00:31:01,760 --> 00:31:05,120
+السوق التفارضي، سعر السوق المبني عن التكلفة الت ..
+
+341
+00:31:05,120 --> 00:31:09,320
+الكلية عفوا هو التكلفة المتغيرة أخر حاجة اليوم إن
+
+342
+00:31:09,320 --> 00:31:13,860
+شاء الله اللي هي سعر التحويل المزدوج مزدوج معناه
+
+343
+00:31:13,860 --> 00:31:18,500
+تنائي إذا سعر التحويل المزدوج معناه سعر تحويل الاش
+
+344
+00:31:18,500 --> 00:31:22,570
+تنائي، معناه عندي سعرينيتم استعمال سعرين مختلفين
+
+345
+00:31:22,570 --> 00:31:27,570
+لتسجيلهم في الدفاتر المحاسبية في حالة بيع و شراء
+
+346
+00:31:27,570 --> 00:31:33,330
+داخل المؤسسة بين الأقسام المختلفة سعر البيع الخارج
+
+347
+00:31:33,330 --> 00:31:36,710
+اللي هو سعر السوق لموضوع بناء على طلبه العرض في
+
+348
+00:31:36,710 --> 00:31:41,490
+السوق أو محدد بناء عليه في دفاتر البائع لذن يا
+
+349
+00:31:41,490 --> 00:31:47,890
+أخوات هذه البائع البائع
+
+350
+00:31:49,710 --> 00:31:54,430
+بحدث سعره الأفضل إله بناء على سعر السوق اللي هو
+
+351
+00:31:54,430 --> 00:31:59,870
+عبّر عنه هام بالبيع الخارجي إيه المشتري، بحطه فوق
+
+352
+00:31:59,870 --> 00:32:06,070
+بحدث
+
+353
+00:32:06,070 --> 00:32:09,410
+سعره بناء على إيش التكلفة المدرية اللي توشرحناها
+
+354
+00:32:09,410 --> 00:32:14,750
+اللي هم رقم واحد ورقم تلاتة إذا يفضل البائع، خد
+
+355
+00:32:14,750 --> 00:32:17,310
+بالي كانت بتيجي في الصحة و الغلط أو في الاختيار،
+
+356
+00:32:17,310 --> 00:32:23,150
+يفضل البائعهو الموظف داخل المؤسسة أن يبيع لموظف
+
+357
+00:32:23,150 --> 00:32:27,630
+آخر داخل نفس المؤسسة بسعر السوق أفضله أعلى ربح
+
+358
+00:32:27,630 --> 00:32:32,650
+بينما المشتري يفضل .. وهو الموظف يفضل يشتر موظف
+
+359
+00:32:32,650 --> 00:32:36,410
+داخل المؤسسة بسعر التكنوفة المتغيرة وهو إيش؟ وهو
+
+360
+00:32:36,410 --> 00:32:42,290
+أفضلها زي ما تقول شراهد البائع بفضل سعر السوق لأنه
+
+361
+00:32:42,290 --> 00:32:46,910
+بيساعده على تحقيق أعلى ربح هو هيك شايفبينما
+
+362
+00:32:46,910 --> 00:32:51,130
+المشتري يفضل الاعتماد على التكلفة المتغيرة لأنها
+
+363
+00:32:51,130 --> 00:32:54,990
+بتحققله أقل تكلفة مثلا كل واحد بدور على مصلحته
+
+364
+00:32:54,990 --> 00:33:00,730
+داخل أو مصلحة في قسمه داخل المؤسسة، إذا سحر السوق
+
+365
+00:33:00,730 --> 00:33:03,150
+عفر أو سحر التحويل المجزور اللي هو الدوناء عند
+
+366
+00:33:03,150 --> 00:33:08,510
+السعرية، البائعاللي هو هودا إله سعر و المشترك اللي
+
+367
+00:33:08,510 --> 00:33:13,630
+هو أنا إليه السعر هودا بتفضل إنها تبيع سلعتها داخل
+
+368
+00:33:13,630 --> 00:33:17,990
+مؤسسة لموظف آخر بسعر السوق ليش يا هودا؟ لأنه بحقق
+
+369
+00:33:17,990 --> 00:33:23,460
+لها أعلى هدف أو أعلى ربحبينما القسم البائع اللي هو
+
+370
+00:33:23,460 --> 00:33:26,480
+انا بفضل اني اشتري عفوا القسم المشتري اللي هو انا
+
+371
+00:33:26,480 --> 00:33:31,480
+بفضل اشتري سعر التكلفة المتغيرة ليش؟ لأنه محققلي
+
+372
+00:33:31,480 --> 00:33:36,100
+أقل ايه؟ أقل تكلفة فخودي بالك التنائي ممكن تيجي من
+
+373
+00:33:36,100 --> 00:33:40,040
+لخبطة نعمل مع بعض عبارات صحوات نشوف كيف اللخبطة
+
+374
+00:33:40,040 --> 00:33:48,560
+بتتيجي يفضل البائع ان يسجل .. هملاحقين ولا أستنى؟
+
+375
+00:33:48,560 --> 00:33:59,880
+ماشي يفضلالبائع أن يسجل في دفاتره سعر السوق بينما
+
+376
+00:33:59,880 --> 00:34:09,620
+المشتري يفضل أن يسجل في دفاتره سعر السوق التفارضي
+
+377
+00:34:09,620 --> 00:34:14,510
+صح ولا غلط؟طبعا هوضح من العبارة خاطئة، ليش خاطئة؟
+
+378
+00:34:14,510 --> 00:34:18,270
+الشوق الأول صح والشوق التاني خطأ، البيارة فعلا أو
+
+379
+00:34:18,270 --> 00:34:21,310
+البيارة بيحب فضل سعر السوق لكل المشتري التكلفة
+
+380
+00:34:21,310 --> 00:34:24,630
+متغيرة مش التفارضي، إذن ورا الخطأ في العبارة اللي
+
+381
+00:34:24,630 --> 00:34:29,390
+هي الشوق التاني من العبارة اللي هو سعر السوق
+
+382
+00:34:29,390 --> 00:34:33,410
+التفارض، سهل هذه، هذه سهلة ليش؟ لأن احنا الكلام ده
+
+383
+00:34:33,410 --> 00:34:39,390
+كله شرحناه قبل شويةأدخل مزايا سعر التحويل المشدوش
+
+384
+00:34:39,390 --> 00:34:43,370
+إليها عدة مزايا استعمال تكلفة مطايرة كسعر تحويل
+
+385
+00:34:43,370 --> 00:34:49,150
+للمشتري بيدفع
+
+386
+00:34:49,150 --> 00:34:53,650
+القسم الباقي لبيع القسم المشتري لأن هذا بزيد ربح
+
+387
+00:34:53,650 --> 00:34:59,830
+القسم الباقيإذن، رقم واحد سعر السوق أو عفوا سعر
+
+388
+00:34:59,830 --> 00:35:04,710
+التحويل التفاوضي بشجع القسم البائع على البيع للقسم
+
+389
+00:35:04,710 --> 00:35:11,390
+المشتري لأنه بزيد أربعة اتنين، معادلة الربح التي
+
+390
+00:35:11,390 --> 00:35:17,130
+كتبناها بيجي البائع كيف بيحسبها؟ حساب بيقول السعر
+
+391
+00:35:17,130 --> 00:35:20,630
+بيساوي التكلفة المتغيرة اللي حكى عنها المشتري زاد
+
+392
+00:35:20,630 --> 00:35:28,750
+همش إيش همش ربح إذن، يتم حسابسعر التحويل للبائع
+
+393
+00:35:28,750 --> 00:35:31,710
+بالمعادلة هذه تاعة المطالبة زاداش؟ أنا مش شابه ليه
+
+394
+00:35:31,710 --> 00:35:38,530
+نسبة معينةهدف السير هذا أنه يشجع البائع والمشتري
+
+395
+00:35:38,530 --> 00:35:42,310
+أو البائع والمشتري على اتخاذ قرارات لصالح المؤسسة
+
+396
+00:35:42,310 --> 00:35:47,750
+بيشجعهم على اتخاذ قرارات لصالح إيش المؤسسة إذا رقم
+
+397
+00:35:47,750 --> 00:35:51,810
+1 استعمال التكل المتغير كسعر من قبل المشتري يشجع
+
+398
+00:35:51,810 --> 00:35:55,270
+البائع على البيع له لأنه بيحققله أرباح رقم 2
+
+399
+00:35:55,270 --> 00:35:58,890
+البائع سيستطيع أن يحسب معادلة السعر التحويل عبارة
+
+400
+00:35:58,890 --> 00:36:01,870
+عن التكل في المتغير زي نسبة معينة اللي هي الربح أو
+
+401
+00:36:01,870 --> 00:36:02,870
+همش إربح
+
+402
+00:36:08,170 --> 00:36:15,150
+ما هي عيوب؟ ما هي عيوب؟ إذا سؤال awkwardly عيوب
+
+403
+00:36:15,150 --> 00:36:21,590
+سعر التحويل المزدوج ببساطة بكلمة واحدة يا أخوات
+
+404
+00:36:21,590 --> 00:36:30,970
+عيوب سعر التحويل المزدوج الإزدواجية إزدواجية
+
+405
+00:36:30,970 --> 00:36:36,150
+.. إزدواجية الحساب تكرار
+
+406
+00:36:38,530 --> 00:36:47,270
+حساب الأرقام يعني بيحكينا طبعا
+
+407
+00:36:47,270 --> 00:36:49,970
+انا يا أخوات المقصود بالأرقام اللي هي الربح بساطة
+
+408
+00:36:49,970 --> 00:36:55,250
+ناخد مثال علشان نفهم الكلام هذا ده خلّي الرسم هنا
+
+409
+00:36:55,250 --> 00:37:02,030
+الان يا أخوات المشتري كيف حسب سعر جال هيك حسب
+
+410
+00:37:02,030 --> 00:37:08,110
+معادلة السعر السعر بيساوي هذا المشتريالتكلفة
+
+411
+00:37:08,110 --> 00:37:14,010
+المتغيرة زاد همش ربح التكلفة المتغيرة عشرة همش ربح
+
+412
+00:37:14,010 --> 00:37:20,230
+خمسة عشان خمس عشر بيقتل
+
+413
+00:37:20,230 --> 00:37:26,730
+بحسبنا السعر بساوي سعر السوق اللي هو نفسه طبعا
+
+414
+00:37:26,730 --> 00:37:29,930
+التكلفة
+
+415
+00:37:29,930 --> 00:37:34,730
+المتغيرة زاد همش ربح نفس هذه ال goal مثلا
+
+416
+00:37:38,370 --> 00:37:48,670
+خمستاش زائد ربح جداش حب تربح جال خمسة هي عشرين اذا
+
+417
+00:37:48,670 --> 00:37:51,770
+الان اللي هترصد في دفاتر المراسل خمستاش ولا
+
+418
+00:37:51,770 --> 00:37:59,810
+العشرين خدي بالك العشرين من ورا اجت خمستاش
+
+419
+00:37:59,810 --> 00:38:05,730
+اللي هي تسعير المشتري زائد خمسة للبائع
+
+420
+00:38:08,130 --> 00:38:13,330
+هذه الخمسة ربح طب كويس و الخمستاشر دي كيف قسمها
+
+421
+00:38:13,330 --> 00:38:20,590
+عشرة تكلفة متغيرة و خمسة ربح إذا أكملة حسبنا الربح
+
+422
+00:38:20,590 --> 00:38:25,130
+احنا في المعادلة مرتين هذه الخمسة اللي هي تبعت
+
+423
+00:38:25,130 --> 00:38:29,190
+المشتري و الخمسة تبعت البائع فهذا بنسميه ازدواجية
+
+424
+00:38:29,190 --> 00:38:35,450
+واضح؟ طب إيش اللي هيترحل لدفاتر المؤسسة؟ خمستاشر
+
+425
+00:38:35,450 --> 00:38:35,750
+فقط
+
+426
+00:38:38,660 --> 00:38:42,740
+طب ليش مش عشرين؟ لو قلنا عشرين، معناها أنا هحسب
+
+427
+00:38:42,740 --> 00:38:50,120
+الربح مرتين ربح المشتري، اللي هو الرقم خمسة و ربح
+
+428
+00:38:50,120 --> 00:38:52,800
+الباع اللي هو خمسة، هيك بيصير عشرة، و حقيقة مافيش
+
+429
+00:38:52,800 --> 00:38:57,940
+عندنا ربح عشر، ربح بس خمسة طب هيكف ساعة عشرين، صار
+
+430
+00:38:57,940 --> 00:39:02,870
+في عندي خلل، ناتج عن وجود سعرين لتسعير السلعإن هو
+
+431
+00:39:02,870 --> 00:39:06,930
+الخلال هذا، إن المشتري بيقول إن السعر بيساوي
+
+432
+00:39:06,930 --> 00:39:11,010
+التكلفة المطايرة زادها مش ربحه، والباقي بيقول
+
+433
+00:39:11,010 --> 00:39:13,110
+السعر بيساوي التكلفة المطايرة زادها مش ربحه، مافيش
+
+434
+00:39:13,110 --> 00:39:16,650
+غلط هنا، لكن لما إجي المشتري يحسبها حسب التكلفة
+
+435
+00:39:16,650 --> 00:39:21,410
+المطايرة، هو مش ربحه، إجي الباع أخد معادلة
+
+436
+00:39:21,410 --> 00:39:26,110
+المشتري، وحطله حاله أرباحهبس حقيقة أن الأرباح
+
+437
+00:39:26,110 --> 00:39:30,650
+انحسبت من أول من إيش؟ من قسم المشترك عشان هيك يجب
+
+438
+00:39:30,650 --> 00:39:34,710
+هدف الأرباح المشتركة اللي هي الرقم خمسة اللي هي
+
+439
+00:39:34,710 --> 00:39:40,610
+الرقم إيش؟ خمسة واضحة ولا عيدها؟ عيدها تاني؟ إذا
+
+440
+00:39:40,610 --> 00:39:45,150
+منعيه بسعر التحويل المزدوج من اسمة إمكانية حصول
+
+441
+00:39:45,150 --> 00:39:49,790
+ازواجية الربح إنه أنا أحسب ربح لهدا وهدا تحسب ربح
+
+442
+00:39:49,790 --> 00:39:54,560
+لنفسهاوهيك بيصير الربح انحسب مرتين وهذا خلل على
+
+443
+00:39:54,560 --> 00:39:57,180
+أرض الواقع بيكون مش موجود أصلا، يعني هتلاقي فيه
+
+444
+00:39:57,180 --> 00:40:01,840
+اختلاف بين البيع اللي صار فعلا و الأرقام و ما بين
+
+445
+00:40:01,840 --> 00:40:09,680
+الكشوفات الكشوفات بتقول الربح 20 أو عفوا السعر تم
+
+446
+00:40:09,680 --> 00:40:16,420
+على 20 على أرض الواقع بنقول السعر تم على 15طب يا
+
+447
+00:40:16,420 --> 00:40:20,260
+جماعة في خمسة زيادة من و اين جايبينها؟ اه جايبينها
+
+448
+00:40:20,260 --> 00:40:24,820
+انه في قسم من الأقسام راح حسب الربح تبع القسم
+
+449
+00:40:24,820 --> 00:40:29,240
+الأولاني مرة تانية اللي موجود في المعادلة فهيك
+
+450
+00:40:29,240 --> 00:40:34,540
+الخمسة هذه عملتلي إيش؟ عملتلي إشكال إيه؟ إتعرفوا و
+
+451
+00:40:34,540 --> 00:40:40,080
+راجعوا تانية من الأول تعرفنا
+
+452
+00:40:40,080 --> 00:40:45,380
+مع بعض أنواع سعر التحويل هم فقط أربعسعر السوق حسب
+
+453
+00:40:45,380 --> 00:40:47,600
+الطلب والعارض، سعر السوق التفارض ويقله مرحلتين
+
+454
+00:40:47,600 --> 00:40:51,260
+فقط، اللي هو أعرف الطلب والعارض جداش في السوق،
+
+455
+00:40:51,260 --> 00:40:53,640
+وبناء عليه بحجة أشوف السعر جداش، أبعد سلعة اتنين،
+
+456
+00:40:53,640 --> 00:40:56,620
+بتفارض، تلاتة، السعر التحويل مبني عن التكلفة
+
+457
+00:40:56,620 --> 00:40:58,860
+الكلية، واخدناها، والتكلفة المتغيرة، واخدناها
+
+458
+00:40:58,860 --> 00:41:03,120
+واتعرفنا على مزاياها، على عيوبها، على الحلول، أخر
+
+459
+00:41:03,120 --> 00:41:06,020
+حاجة أخدناها السعر التحويل التنائي أو المزدوج،
+
+460
+00:41:06,020 --> 00:41:11,820
+وحكينا تنائي أو مزدوج يعني يقله سعرينالبائع له سعر
+
+461
+00:41:11,820 --> 00:41:15,100
+و المشتري له سعر و شوفنا مع بعض كم يمكن نحل
+
+462
+00:41:15,100 --> 00:41:25,560
+المشاكل إيه بتاعك؟ أخر حاجة اللي هي أيهما أفضل؟
+
+463
+00:41:25,560 --> 00:41:33,220
+أيهما إيش؟ أيهما أفضل؟ عندنا أربع، مين أحسن واحد؟
+
+464
+00:41:33,220 --> 00:41:38,000
+كمان بعض، مش واحد أحسن من التاني، لا يوجد سعر مفضل
+
+465
+00:41:38,980 --> 00:41:43,700
+لكن الظروف بتحكمنا، ايش الظروف؟ حسب السوق وحسب
+
+466
+00:41:43,700 --> 00:41:47,540
+أهداف الإدارة العليا، إذا مافيش سعر مفضل، مافيش
+
+467
+00:41:47,540 --> 00:41:50,980
+سعر بنقدمه على الآخر، كل أسعار التحويل إليها مزايا
+
+468
+00:41:50,980 --> 00:41:54,560
+وعيوب زي ما شوفنا مع بعض، بيحكيلي لوجه السعر
+
+469
+00:41:54,560 --> 00:41:59,220
+المفضل حسب السوق وأهداف إيش الإدارة العليا السعر
+
+470
+00:41:59,220 --> 00:42:03,900
+اللي بيصلح اليوم كسعر تحويل، ليس بالضرورة أن يصلح
+
+471
+00:42:03,900 --> 00:42:07,990
+في المستقبلإذا الطريقة التي تصلح في دروف معينة قد
+
+472
+00:42:07,990 --> 00:42:11,210
+لا تصلح في دروف أخرى عشان هيك لازم يكون عندنا
+
+473
+00:42:11,210 --> 00:42:16,290
+ملونة في التسعير اليوم بسعر السوق ممكن الشهر الجاي
+
+474
+00:42:16,290 --> 00:42:20,530
+سعر السوق تفارضي الشهر اللي بعد و أرجع لسعر السوق
+
+475
+00:42:20,530 --> 00:42:23,930
+ممكن أروح لسعر السوق التنائب و أحكي لازم يكون
+
+476
+00:42:23,930 --> 00:42:27,650
+عندنا ياشطر لازم يكون عندنا ملونة عند اختيار سعر
+
+477
+00:42:27,650 --> 00:42:33,350
+قطة واضحة ولا أعيدها؟ أعيدها تاني؟ ليه السؤال؟
+
+478
+00:42:34,420 --> 00:42:37,020
+نكتفي بهذا القدر اليوم، في أي سؤال في المحاضرة
+
+479
+00:42:37,020 --> 00:42:44,220
+اليوم؟ أتوقع موضوع بسيط وشيق ومش معقد، في أي سؤال
+
+480
+00:42:44,220 --> 00:42:46,880
+أو استفسار؟ أي سؤال؟ يعطيكوا العافية
+
diff --git a/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/yOyAN8R9VNs_postprocess.srt b/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/yOyAN8R9VNs_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..e2bd0fd74109474674bdad85111119ddccce4a6c
--- /dev/null
+++ b/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/yOyAN8R9VNs_postprocess.srt
@@ -0,0 +1,1808 @@
+1
+00:00:20,920 --> 00:00:23,400
+اعودوا بالله السميع العليم من الشيطان الرجيم بسم
+
+2
+00:00:23,400 --> 00:00:26,620
+الله الرحمن الرحيم الحمد لله والصلاة والسلام على
+
+3
+00:00:26,620 --> 00:00:31,320
+المصطفى الأمين سيدنا محمد وعلى آله ومن ساره على
+
+4
+00:00:31,320 --> 00:00:34,100
+دربي بحسن اليوم الدنيا في بداية السلام عليكم ورحمة
+
+5
+00:00:34,100 --> 00:00:38,480
+الله كيف حالكم؟ كيف أصبحتوا اليوم كويسين ان شاء
+
+6
+00:00:38,480 --> 00:00:44,720
+الله؟مازلنا في المحاضرة التانية في موضوع الموازنات
+
+7
+00:00:44,720 --> 00:00:49,540
+التشغيلية، تعرفنا عليها المحاضرة الماضية وميزنا
+
+8
+00:00:49,540 --> 00:00:55,400
+بينها و بين الموازنات الرئيس مالية، بعدين تعرفنا
+
+9
+00:00:55,400 --> 00:00:58,260
+على أقسامها وحكينا إن حجر الأساس إيه اللي هو
+
+10
+00:00:58,260 --> 00:01:03,860
+المبيعات، من غير مبيعات أنا ما بقدر أتصرف، من غير
+
+11
+00:01:03,860 --> 00:01:09,610
+مبيعات إحنا إشملنا، ماقدر نتصرفالماضي الماضي بدينا
+
+12
+00:01:09,610 --> 00:01:19,270
+بيه اللي هو موازنة المبيعات تعرفنا عليها خدنا
+
+13
+00:01:19,270 --> 00:01:24,230
+سؤالين اليوم هنكمل هذا
+
+14
+00:01:24,230 --> 00:01:33,890
+كله اتطلقناله حلنا السؤال هذا و هذا حلناه عندنا
+
+15
+00:01:33,890 --> 00:01:40,110
+السؤال هذا example 3 او example threeتفضلي أخت
+
+16
+00:01:40,110 --> 00:01:46,450
+كفاية قراينا سؤال لدى شركة الفن لصناعة السابون
+
+17
+00:01:46,450 --> 00:01:52,510
+ثلاث مناطق القدس، عكا، ناصر، ناصر في عنا شركة
+
+18
+00:01:52,510 --> 00:01:57,850
+بتصنع السابونة بتوزع هي تلت مناطق الناصرة والقدس
+
+19
+00:01:57,850 --> 00:02:03,290
+عكا والقدس وبعد دراسة الصفوة تنبؤ بالكميات
+
+20
+00:02:03,290 --> 00:02:08,090
+والاسعار اتضح الاسم بالنسبة للناصرة الناصرة جداش
+
+21
+00:02:08,090 --> 00:02:08,650
+بتبعت
+
+22
+00:02:14,040 --> 00:02:19,720
+الناصرة تستوعب أربعتاشر ألف كرتون سابون، ممكن نقول
+
+23
+00:02:19,720 --> 00:02:24,640
+كرتونها تلاتة و خمسين، عكّة؟ أربعتاشر ألف عكّة،
+
+24
+00:02:24,640 --> 00:02:30,060
+السعر خمسين، والكمية عشر تلاف .. بنبعت لعكّة عشر
+
+25
+00:02:30,060 --> 00:02:35,440
+تلاف و خمسين دولار، القدس؟ السعر تمانية و أربعين،
+
+26
+00:02:35,440 --> 00:02:38,080
+والكمية سبعتاشر ألف .. نبعتلها سبعتاشر ألف تمانية
+
+27
+00:02:38,080 --> 00:02:43,030
+و أربعين، طيبالشركة لا تستطيع الوفاة بما يديد عن
+
+28
+00:02:43,030 --> 00:02:47,850
+أربعين ألف واحدة من المرتبط الشركة الطاقة القصوى
+
+29
+00:02:47,850 --> 00:02:51,990
+لإنتاج الصابون في شركة الفجر فقط أربعين ألف واحدة
+
+30
+00:02:51,990 --> 00:02:56,610
+وكانت سياسة الشركة كاملةإذا نحط خط تحت كلمة سياسة
+
+31
+00:02:56,610 --> 00:03:00,370
+الشركة، إيش سياسة الشركة؟ الوفاء باحتياجات من
+
+32
+00:03:00,370 --> 00:03:04,770
+منطقة القدس والناصرة من المصنع بأبعد للقدس من ال
+
+33
+00:03:04,770 --> 00:03:09,730
+40 ألف اللي في المصنع و بعدين الناصرة و نضل حاجة
+
+34
+00:03:09,730 --> 00:03:14,770
+لعكة، اه يمكن العكة ما يضلش و يمكن يضل مش عارفين و
+
+35
+00:03:14,770 --> 00:03:18,950
+تبلغ معدلات بيع المنتج خلال فصول السنة نانو ستة و
+
+36
+00:03:18,950 --> 00:03:22,940
+خمسة أربعةيعني هدى يا أخوات فى شهر اتنين بتفع
+
+37
+00:03:22,940 --> 00:03:25,900
+الطلب فى شهر ستة فى شهر خمسة فى شهر أربعة تعدى
+
+38
+00:03:25,900 --> 00:03:29,840
+موازنة المبيعات حسب سياسات الشركة وحسب كل فصل من
+
+39
+00:03:29,840 --> 00:03:32,500
+فصوله شكرا يانت مطلوب مننا شغلتين أول حاجة
+
+40
+00:03:32,500 --> 00:03:37,620
+الموازنة حسب سياسة الشركة بعدين الموازنة حسب فصول
+
+41
+00:03:37,620 --> 00:03:44,780
+السنة تعالوا نبدأ انحل شوية شوية فانحنقول مع بعض
+
+42
+00:03:44,780 --> 00:03:52,870
+ركزوا معانا لو سمحتواواحد الموازنة بموازنة نبعات
+
+43
+00:03:52,870 --> 00:04:01,170
+حسب سياسة الشركة انطلع سياسة الشركة من السؤال
+
+44
+00:04:01,170 --> 00:04:13,350
+الجزء
+
+45
+00:04:13,350 --> 00:04:17,810
+الكلي او اللي هو الاحتياجات زي ما احنا عايزينخلّي
+
+46
+00:04:17,810 --> 00:04:25,530
+الاحتياجات هادي نبدأ
+
+47
+00:04:25,530 --> 00:04:36,610
+مع بعض أول حاجة قداش حجم إنتاج المصنع أربعين ألف،
+
+48
+00:04:36,610 --> 00:04:41,570
+أربعين ألف إذا قداش حجم إنتاج المصنع أربعين ألف،
+
+49
+00:04:41,570 --> 00:04:46,270
+لو أننا جيبناها مطنية في سوق، لأي منطقة بودوا جبل؟
+
+50
+00:04:48,290 --> 00:04:54,410
+احتياجات القدس؟ قداش القدس بتحتاج؟ اربعتاشر ألف
+
+51
+00:04:54,410 --> 00:04:58,670
+بعد
+
+52
+00:04:58,670 --> 00:05:04,410
+القدس خلاص و لا في حد؟ في الناصرة الناصرة اربعتاشر
+
+53
+00:05:04,410 --> 00:05:11,450
+اربع .. الناصر اربعتاشر الف اجمالي
+
+54
+00:05:11,450 --> 00:05:17,210
+الاحتياجات؟ سبعتاشر
+
+55
+00:05:17,210 --> 00:05:17,930
+لدى اربعتاشر
+
+56
+00:05:25,180 --> 00:05:30,360
+في حد بيسأل نفسه من أين جابوها؟ إذا أنا عندي
+
+57
+00:05:30,360 --> 00:05:35,140
+أربعين ألف كرتون سابون لما أبعت للقدس والناصرة
+
+58
+00:05:35,140 --> 00:05:40,960
+احتياجاتهم بيضل عندنا مين؟ واحد و تلاتين ألف ضل
+
+59
+00:05:40,960 --> 00:05:51,180
+عندنا منطقة عكا احتياجات عكاقداش عد كم احتاجة؟
+
+60
+00:05:51,180 --> 00:05:59,440
+عشرة تلاف عشرة تلاف قداش
+
+61
+00:05:59,440 --> 00:06:06,120
+عد كم احتاجة؟ عشرة تلاف احسبي لو سمحتي أربعين ناقص
+
+62
+00:06:06,120 --> 00:06:13,920
+واحد تلاتين ستة ألف ممكن نحطه هان المتبقي
+
+63
+00:06:20,550 --> 00:06:23,010
+إذا إحنا بعد ما نوزع القدس و الناس، قداش بيظل
+
+64
+00:06:23,010 --> 00:06:27,190
+عندنا؟ تسعة تلات، عكى قداش بدها؟ عشرة تلات عندنا
+
+65
+00:06:27,190 --> 00:06:35,130
+عاجز ولا فائض؟ عاجز ألف أعيدها؟
+
+66
+00:06:35,130 --> 00:06:40,810
+حاضر يعني، الآن أنا عندي في المصنع أربع وعشرين
+
+67
+00:06:40,810 --> 00:06:46,650
+ألف، عفوا، أربعين ألف صندوق صابون، بعثنا للقدس
+
+68
+00:06:46,650 --> 00:06:52,340
+حصتهم حسب السؤال سبعتاشر ألفو بعدين بعتنا للناصرة
+
+69
+00:06:52,340 --> 00:06:57,320
+حصتها 14 ألف ممكن طالبة بتحكي شمال القدس والناصرة
+
+70
+00:06:57,320 --> 00:07:00,640
+جابل أشمش عكّة لأن هو في السورة حاكمني قايدني في
+
+71
+00:07:00,640 --> 00:07:04,320
+السورة لما بعتنا للقدس والناصرة طلعوا أجمعي اللي
+
+72
+00:07:04,320 --> 00:07:13,020
+بعتناه 31 ألف ليه 17 زي 14 40 ألف كله مع بعض ناقص
+
+73
+00:07:13,020 --> 00:07:20,080
+31 بعتناه مجدش غايل 9000 مجدش احتياجات عكّة 10000
+
+74
+00:07:21,140 --> 00:07:25,460
+هل هابعت لعكة لعشرة تلاف ولا ماضلش عندي؟ هبعدلها
+
+75
+00:07:25,460 --> 00:07:29,080
+التسعة ويكون عندنا عاجز، الألف، من ورا الألف،
+
+76
+00:07:29,080 --> 00:07:32,740
+العكة تدبر حالها عاد، مش احنا، الألف العاجز احنا
+
+77
+00:07:32,740 --> 00:07:36,140
+قلنا فيهم لأ، هدولة العكة هي تدبر حالها، تجيبها من
+
+78
+00:07:36,140 --> 00:07:43,020
+مصنع تاني، هي حلوة، أعيدهم تاني؟ فضلي، إذا أنا
+
+79
+00:07:43,020 --> 00:07:50,260
+عندي في المصنع أربعين ألف كرتونة كولة، ماشي؟حسب
+
+80
+00:07:50,260 --> 00:07:55,080
+سياسة المؤسسة، بابعت للقدس حصتها من الرابعين ألف،
+
+81
+00:07:55,080 --> 00:07:59,320
+اللي سبعتاشر ألف، و بعدين بابعت للناصر حصتها ليه
+
+82
+00:07:59,320 --> 00:08:04,340
+قداشر؟ أربعتاشر، إذا بابعت للقدس و للناصر، عاد كأن
+
+83
+00:08:04,340 --> 00:08:08,760
+ضال حاجة من المنتج بنبعته، ماضلش خلاص يعني
+
+84
+00:08:08,760 --> 00:08:15,560
+المنافسينبعتنا سبعتاش واربعتاش لما جمعناهم سبعتاش
+
+85
+00:08:15,560 --> 00:08:19,220
+ألف زي الاربعتاش قدش طلع؟ واحد تلاتين ألف، احسبيه
+
+86
+00:08:19,220 --> 00:08:26,240
+لواحد
+
+87
+00:08:26,240 --> 00:08:30,720
+تلاتين ألف إجمالي مش جزءي، القدس والناصر هدول
+
+88
+00:08:30,720 --> 00:08:36,020
+جزييات، بينما المصنع بيكون كل شغل إجماليواحد و
+
+89
+00:08:36,020 --> 00:08:42,240
+تلاتين ألف طيب أربعين ألف علبة كولا وزقت منها واحد
+
+90
+00:08:42,240 --> 00:08:48,400
+و تلاتين جداش ضايل تسعة نيجي على أكا جداش أكا
+
+91
+00:08:48,400 --> 00:08:53,880
+بدكوا بدنا عشرة ألف احنا ماعناش غير تسعة جداش
+
+92
+00:08:53,880 --> 00:09:00,440
+العجل صار عشرة ألف ناقص أسعة ألف ألف أعيدها أعيدها
+
+93
+00:09:00,440 --> 00:09:06,910
+تاني أعيدها أعيدها مش مشكلة أعيدهاإن شاء الله.
+
+94
+00:09:07,510 --> 00:09:14,070
+الآن يا أخوات كنا متفقين مع عكا إذا بعتنا لهم
+
+95
+00:09:14,070 --> 00:09:22,430
+العشر تلاف جداش السعر؟ السؤال؟ طلب السرخانة عكا
+
+96
+00:09:22,430 --> 00:09:25,650
+كنا متفقين حسب السؤال إذا أنا بعتلهم عشر تلاف
+
+97
+00:09:25,650 --> 00:09:30,970
+كرتونة يكونوا بخمسين لكن الآن أنا ما راح أبعت عشر
+
+98
+00:09:30,970 --> 00:09:38,560
+تلاف راح أبعت جداش تسعة تلافالسعر لازم يتغير إذا
+
+99
+00:09:38,560 --> 00:09:44,780
+بما أنه ظهر عندنا عجز تسعة آلاف يا أحلام مش هنضلنا
+
+100
+00:09:44,780 --> 00:09:48,240
+على الخمسين إيش الخمسين؟ السعر أنا بحكي عن عكة
+
+101
+00:09:48,240 --> 00:09:50,640
+مالاش إلا قداجي ماعندهوش مشاكل عكة اللي عندها
+
+102
+00:09:50,640 --> 00:10:01,100
+مشاكل الآن السعر هيتغير في حالة انخفاض العرض إيش
+
+103
+00:10:01,100 --> 00:10:06,380
+بيصير في السعر؟ ب zero ولا بقل؟بزيه .. بزيه ..
+
+104
+00:10:06,380 --> 00:10:11,340
+بزيه .. بزيه .. بزيه .. بزيه .. بزيه .. بزيه ..
+
+105
+00:10:11,340 --> 00:10:15,100
+بزيه .. بزيه .. بزيه .. بزيه .. بزيه .. بزيه ..
+
+106
+00:10:15,100 --> 00:10:15,860
+بزيه .. بزيه .. بزيه .. بزيه .. بزيه .. بزيه ..
+
+107
+00:10:15,860 --> 00:10:15,960
+بزيه .. بزيه .. بزيه .. بزيه .. بزيه .. بزيه ..
+
+108
+00:10:15,960 --> 00:10:16,740
+بزيه .. بزيه .. بزيه .. بزيه .. بزيه .. بزيه ..
+
+109
+00:10:16,740 --> 00:10:18,400
+بزيه .. بزيه .. بزيه .. بزيه .. بزيه .. بزيه ..
+
+110
+00:10:18,400 --> 00:10:22,760
+بزيه .. بزيه .. بزيه
+
+111
+00:10:22,760 --> 00:10:26,060
+.. بزيه
+
+112
+00:10:26,060 --> 00:10:32,310
+.. بزيه .. بزيه .. بزيهخودي بالك لغاية الآن احنا
+
+113
+00:10:32,310 --> 00:10:35,110
+ماتجيبناش الموازنة لغاية الآن احنا جاعدين بنشوف
+
+114
+00:10:35,110 --> 00:10:39,390
+إيش بتصير في المنتج و كده إيش هنبعد هنقول مع بعض
+
+115
+00:10:39,390 --> 00:10:48,410
+هان سيتغير يتغير
+
+116
+00:10:48,410 --> 00:10:58,730
+سعر مدينة عكا و ذلك لووجود عجز
+
+117
+00:11:00,450 --> 00:11:08,070
+جدّاش السعر يا أخوات؟ السعر القديم ضرب نسبة العجز
+
+118
+00:11:08,070 --> 00:11:15,310
+زاد السعر القديم بساوة جدّاش سعرنا القديم في
+
+119
+00:11:15,310 --> 00:11:21,750
+السؤال اللي عكّى؟ خمسين جدّاش نسبة العجز؟ ألف
+
+120
+00:11:21,750 --> 00:11:27,010
+تقسيم عشرة تلاف اللي هو المطلوب إذا المين هذا
+
+121
+00:11:27,010 --> 00:11:29,650
+العجز؟ هو هذا الإجمال المطلوب زاد خمسين
+
+122
+00:11:33,160 --> 00:11:39,040
+عكتبها على طول يعني ولا كتب خمسة زائد خمسين؟
+
+123
+00:11:39,040 --> 00:11:44,920
+إذا إيه جداش سعر عكسها؟ مش خمسين مش زي السؤال،
+
+124
+00:11:44,920 --> 00:11:47,840
+ليش؟ لأنه فيه عجز، إيش يعني عجز؟ يعني انخفاض
+
+125
+00:11:47,840 --> 00:11:50,640
+العرض، إيش يعني انخفاض العرض؟ يعني زيادة السعة
+
+126
+00:11:50,640 --> 00:11:57,300
+واضح ليش القدس والناس اللي دلوا زي ما هم بينما عكة
+
+127
+00:11:57,300 --> 00:12:01,560
+هي اللي غيرنا عليها أمسح؟
+
+128
+00:12:04,900 --> 00:12:10,600
+واضحة ولا عيدها؟ عيدها؟ كأنه احنا بنطلع الخلل تبع
+
+129
+00:12:10,600 --> 00:12:15,420
+الألف في السعة نفسه عشان ما نخسرش معايا ولا صعب؟
+
+130
+00:12:15,420 --> 00:12:22,580
+سهلة؟ او سهل؟ ان انا بنجيب الموازن زي ما تعودنا؟
+
+131
+00:12:41,960 --> 00:12:48,860
+القدس، الناصرة، عكا قداش
+
+132
+00:12:48,860 --> 00:12:56,300
+غدير مبيعات القدس بالوحدة قداش سعرها؟ ماتغيرش،
+
+133
+00:12:56,300 --> 00:13:03,750
+مافيش مشاكل في القدس، الناصرة سعرها 53عاكر قداشة
+
+134
+00:13:03,750 --> 00:13:07,350
+حنبقت لها؟ تسعة للالات تسعة و خمسة و خمسية همتاز
+
+135
+00:13:07,350 --> 00:13:10,770
+هذا بس التغيير طبعا درب هذا يا أخوتي يا أخواتي هذا
+
+136
+00:13:10,770 --> 00:13:18,090
+درب أضربيه سبعتاشر الف تمانية و أربعين طبعا
+
+137
+00:13:18,090 --> 00:13:22,190
+ساعتها اندولار هدي واحدة سبعمية و كيلو أرويه
+
+138
+00:13:22,190 --> 00:13:29,090
+أربعين أربعين أربعين و خمسة و خمسين ممكن
+
+139
+00:13:29,090 --> 00:13:31,330
+نجيب الإجمالي مش مشكلة ممكن نجيبه عادي
+
+140
+00:13:34,860 --> 00:13:39,160
+في حد عنده مشكلة؟ في حد بيقول من وين جابوا الحاجات
+
+141
+00:13:39,160 --> 00:13:44,160
+هذه؟ أعيد تاني، إذا الحاجة البسيطة اللي فيها مشكلة
+
+142
+00:13:44,160 --> 00:13:52,000
+كانت إن عكا صار عندها خلل صار عندها إيش؟ عجز إذا
+
+143
+00:13:52,000 --> 00:13:54,600
+هذا كان المطلوب الأول في السؤال، احسب موازنة
+
+144
+00:13:54,600 --> 00:14:00,180
+المبيعات حسب السياسة السياسة كانت اللي هي القدس
+
+145
+00:14:00,180 --> 00:14:03,160
+الناصر عكا، المطلوب التاني
+
+146
+00:14:06,500 --> 00:14:10,900
+احسب الموازنة حسب كل فصل من فصول السنة ماعطينا
+
+147
+00:14:10,900 --> 00:14:15,060
+اتنين، ستة، خمسة، اربعة هنعملها للقدس وانتوا
+
+148
+00:14:15,060 --> 00:14:26,420
+بتكملوا في البيت لباقية المناطق أمسة؟ عاوزة تجمس؟
+
+149
+00:14:26,420 --> 00:14:29,840
+خلاص؟
+
+150
+00:14:29,840 --> 00:14:33,660
+اه ممكن تطلع إيادة صح أمسة؟
+
+151
+00:14:36,570 --> 00:14:41,750
+إذا الأول إيش هنجيب؟ ماشي ممتاز، اللي هو المطلوب
+
+152
+00:14:41,750 --> 00:14:45,790
+التاني في الساعة هنقول
+
+153
+00:14:45,790 --> 00:14:51,970
+الموازنة لمنطقة
+
+154
+00:14:51,970 --> 00:14:57,310
+القدس لمنطقة
+
+155
+00:14:57,310 --> 00:15:07,040
+القدس حسب فصول السنةإذا إيش هنجيب الآن؟ الموازنة
+
+156
+00:15:07,040 --> 00:15:12,080
+حسب فصول السنة بس القُلص، ماشي؟ بس الشهر .. السفر
+
+157
+00:15:12,080 --> 00:15:15,220
+اللي قبل اللي هو هذا اللي هو ده اتنين، ستة، خمسة،
+
+158
+00:15:15,220 --> 00:15:20,320
+أربعة، و هذا الفصول اللي هو النوم، شهور يعني؟
+
+159
+00:15:20,320 --> 00:15:25,370
+ممكن، بس نكتبها بالترتيب أفضل يا جماعةممكن شهور،
+
+160
+00:15:25,370 --> 00:15:27,890
+ممكن أنه في فصل الربيع أو في فصل الشتاء، هذا
+
+161
+00:15:27,890 --> 00:15:32,010
+بيطلع، بنركز عليه، فصل الربيع، فصل الربيع برضه
+
+162
+00:15:32,010 --> 00:15:37,130
+هذا، فصل الصيف أو هذا الخريف ممكن يكون سواء فصول
+
+163
+00:15:37,130 --> 00:15:41,730
+أو شهور، نفس الحالة المبيعات بالوحدة، خودي بالك
+
+164
+00:15:41,730 --> 00:15:45,630
+للقدس بس السعر
+
+165
+00:15:45,630 --> 00:15:48,850
+الموازنة
+
+166
+00:15:48,850 --> 00:15:53,030
+نوم كتبناها، بيطلع في السؤال، اللي هي الفترة
+
+167
+00:15:53,030 --> 00:15:59,150
+الزمنيةقداش سعر منطقة القدس؟
+
+168
+00:15:59,150 --> 00:16:05,750
+تاخدنا مليون و أربعين ماعطيكي أفى سؤال بس
+
+169
+00:16:05,750 --> 00:16:09,590
+لقدس هجيب المبيعات
+
+170
+00:16:09,590 --> 00:16:14,850
+بإيش؟ بالوحدة كيف
+
+171
+00:16:14,850 --> 00:16:18,950
+هنجيبها؟ هده يا أخوات؟ هجيبها كلها أربع تاشر ألف
+
+172
+00:16:18,950 --> 00:16:23,970
+مفهوش لإنه أربع تاشر .. سبعتاشر يعنيهذه كانت ناصرة
+
+173
+00:16:23,970 --> 00:16:27,790
+انت من الناصرة ولا من وين؟ انا من القدس ماشي منيح
+
+174
+00:16:27,790 --> 00:16:33,070
+ان شاء الله نصلي مع بعض هناك منفعش
+
+175
+00:16:33,070 --> 00:16:37,110
+اقول سبعتاشر تمانية واربعين غلطتك لازم نوزعهم خدي
+
+176
+00:16:37,110 --> 00:16:42,950
+بالك هنقول مبيعات .. هاي الحالة هدهامش يا أخوات
+
+177
+00:16:42,950 --> 00:16:47,830
+ماجيش معاك جدول مبيعات القدس هتساوي؟
+
+178
+00:16:49,110 --> 00:16:54,390
+مبيعات القدس لكل شهر أو لكل فترة، حتساوي؟ المبيعات
+
+179
+00:16:54,390 --> 00:17:02,830
+ضرب الشهر ع الإجمالي كاف يعني، تعالي نطبق مبيعات
+
+180
+00:17:02,830 --> 00:17:08,990
+القدس لشهر اتنين، حتساوي؟ سبعتاشر الف .. سبعتاشر
+
+181
+00:17:08,990 --> 00:17:14,330
+الف في اتنين على ضرب، احنا في شهر اتنين، اتنين
+
+182
+00:17:14,330 --> 00:17:17,370
+هيكون قاعد فوق في ال bus ع الإجمالي اللي هو اتنين
+
+183
+00:17:18,330 --> 00:17:25,830
+زائد شهر أربعة زائد خمسة زائد ستة، إذا سهلة تطلع
+
+184
+00:17:25,830 --> 00:17:29,710
+ألفين، لازم يا أخوات يطلع رقم صغنون، مش صغنون على
+
+185
+00:17:29,710 --> 00:17:34,610
+الآخر، منطقي يعني، إيش يعني ألفين؟ يعني من
+
+186
+00:17:34,610 --> 00:17:37,450
+السبعتاشر .. من السبعتاشر ألف في شهر اتنين هابعد
+
+187
+00:17:37,450 --> 00:17:42,590
+ألفين بسطب ده الخمستاشر، في تلت شهور لهم، ماشي،
+
+188
+00:17:42,590 --> 00:17:47,290
+كمان واحدة؟ مبيعات .. اه يا مريم، يلا مبيعات القدس
+
+189
+00:17:47,290 --> 00:17:52,390
+لشهر أربع .. سبعتاشر ألف دره .. سبعتاشر ألف دره ..
+
+190
+00:17:52,390 --> 00:17:55,590
+أربع تقصير .. ممتازة يا وانتي، أربع تقصير .. اتنين
+
+191
+00:17:55,590 --> 00:17:57,470
+.. اتنين .. اتنين .. اتنين .. اتنين .. اتنين ..
+
+192
+00:17:57,470 --> 00:17:58,110
+اتنين .. اتنين .. اتنين .. اتنين .. اتنين .. اتنين
+
+193
+00:17:58,110 --> 00:17:58,210
+.. اتنين .. اتنين .. اتنين .. اتنين .. اتنين ..
+
+194
+00:17:58,210 --> 00:18:03,050
+اتنين .. اتنين .. اتنين .. اتنين .. اتنين .. اتنين
+
+195
+00:18:03,050 --> 00:18:07,690
+.. ا
+
+196
+00:18:09,330 --> 00:18:21,150
+قداش ضايل؟ ست آلاف ناقص سبعتاشر ألف؟ ماشي كيف
+
+197
+00:18:21,150 --> 00:18:27,630
+ألف و ميان؟ ست آلاف، كيش بيكون ضايل؟ أحداشر ألف؟
+
+198
+00:18:27,630 --> 00:18:32,410
+ألف و مية مشكلة، وين أنا وين وديت بجيت لك ضاع؟ أه
+
+199
+00:18:32,410 --> 00:18:37,490
+أه، عشانك صار عندي مشكلة أنا مين يعمل شهر خمسة؟
+
+200
+00:18:37,490 --> 00:18:44,810
+أسمع17000 ضرب 5 على 2 زي 4 زي 5 زي 6 و هيطلع خمس
+
+201
+00:18:44,810 --> 00:18:49,850
+تلاف خمس تلاف نقصهم و نطلع .. اه يا سامور جدش سنة
+
+202
+00:18:49,850 --> 00:18:56,430
+بعتين .. جدش سنة بعتين .. ناشر .. جدش سنة بعتين
+
+203
+00:18:56,430 --> 00:18:59,670
+القدس؟ وين ايه يا سامور؟ خمسة و أربعة اصلا احداشر،
+
+204
+00:18:59,670 --> 00:19:01,570
+جدش ضلهم؟ ستة و أربعة اصلا احداشر، وين لازم هاد
+
+205
+00:19:01,570 --> 00:19:05,490
+كون؟ لو هالك صح .. لو يعني طبقت المعادلة هاد لازم
+
+206
+00:19:05,490 --> 00:19:10,900
+تطلع هنالما تجمعيهم يطلعوا السبعتاشر ألف، إذا
+
+207
+00:19:10,900 --> 00:19:15,400
+السبعتاشر ألف كرتونة صابونة لمنطقة القدس، بدي
+
+208
+00:19:15,400 --> 00:19:19,660
+أبعتهم للقدس على أربع فترات أو أربع مرات، إسراء
+
+209
+00:19:19,660 --> 00:19:23,860
+دبور، المرة الأولى جدش هتبعتيلهم، شهر اتنين؟
+
+210
+00:19:27,260 --> 00:19:31,380
+هت .. هنبعت .. لأ دي مصاري بصير، هنبعتله من فين
+
+211
+00:19:31,380 --> 00:19:35,360
+كرتون، في شهر أربع جداش هتبعتي أربع تلاف تكون
+
+212
+00:19:35,360 --> 00:19:40,380
+مجهزاها، في شهر خمسة أخر حاجة تضللهم عند الجداش،
+
+213
+00:19:40,380 --> 00:19:44,520
+ست تلاف، هذي بالوحدة، جداش الموازنة اللي هي
+
+214
+00:19:44,520 --> 00:19:47,640
+الإيراداتي، الفين في تمانية واربعين
+
+215
+00:19:50,180 --> 00:19:55,520
+خودي بالك دولار؟ مية و اتنين و تسعين ألف، اربع
+
+216
+00:19:55,520 --> 00:19:59,100
+ألف، ميتين و أربعين ألف، ميتين و تمانين و تمانين
+
+217
+00:19:59,100 --> 00:20:04,200
+ألف، ميتين و تمانين و تمانين ألف خودي بالك مانفعش
+
+218
+00:20:04,200 --> 00:20:07,160
+أقول هبعتلهم ستة و تسعين ألف، هذي مصاري، ماببعتش
+
+219
+00:20:07,160 --> 00:20:11,860
+أنا مصاري، لأ مابعت كمية، أنا هابعتلأ سيدة الأعمال
+
+220
+00:20:11,860 --> 00:20:16,780
+غدير اللي في القدس ألفين كرتونة صابونة هي هتبعت
+
+221
+00:20:16,780 --> 00:20:21,260
+حجهم جداش؟ 96 ألف حاجة في شهر أربع بعتلها 4000
+
+222
+00:20:21,260 --> 00:20:25,220
+جداش تبعت حجهم؟ 199 ألف واضح، كل ما بيزيد، بيزيد
+
+223
+00:20:25,220 --> 00:20:30,700
+السعر، إذا هذه حقوقي أنا اللي هي الموازنة بالدولار
+
+224
+00:20:30,700 --> 00:20:34,980
+و هذه الكميات اللي أنا لازم أجهزها و أبعتها للناس،
+
+225
+00:20:34,980 --> 00:20:38,660
+الالتزامات، برك الله فيك واضح ولا أعيدها تاني؟
+
+226
+00:20:38,660 --> 00:20:40,140
+أعيدها تاني؟
+
+227
+00:20:42,720 --> 00:20:47,800
+نشوف ال sheet في
+
+228
+00:20:47,800 --> 00:20:53,120
+حاجة .. في حد أفهم حاجة؟ عيد .. بعيد تاني مش
+
+229
+00:20:53,120 --> 00:21:00,760
+مشكلة، عيد؟ عيدها تاني؟ عيد اي اسمها؟ بقت تعب انا؟
+
+230
+00:21:00,760 --> 00:21:05,640
+ماشي ان شاء الله، الآن عندنا ال sheet سؤال رقم
+
+231
+00:21:05,640 --> 00:21:06,380
+تلاتة
+
+232
+00:21:08,810 --> 00:21:13,490
+اقرأينا يا يهودا، معاك ال sheet يا انتي؟ سؤال
+
+233
+00:21:13,490 --> 00:21:19,930
+تلاتة يا خوات شركة العودة؟
+
+234
+00:21:19,930 --> 00:21:27,430
+في
+
+235
+00:21:27,430 --> 00:21:29,790
+حد عنده مشكلة في الحساب؟ اه يا سيد الدبور، عندك
+
+236
+00:21:29,790 --> 00:21:34,330
+مشكلة؟ ماشي ان شاء الله، يلا يا هودا اقرأينا
+
+237
+00:21:34,330 --> 00:21:36,330
+السؤال بشوش، سؤال التالت
+
+238
+00:21:56,080 --> 00:21:59,360
+ممتع زي ستة و نص مش ستمية و خمسة ايوة
+
+239
+00:22:07,710 --> 00:22:14,470
+أه قداش إنتاج الشركة 6000 إذا
+
+240
+00:22:14,470 --> 00:22:17,750
+ننقص
+
+241
+00:22:17,750 --> 00:22:25,670
+بعدين يا فإن ضال حاجة لتالي ضابير الهدف
+
+242
+00:22:25,670 --> 00:22:35,290
+تتجارب من الشمال يا انتي شكرا
+
+243
+00:22:35,290 --> 00:22:38,850
+يا هودة، مين حاب يحل رقم واحد؟مين كمان؟ يالا يا
+
+244
+00:22:38,850 --> 00:22:43,850
+مريم اتفضلي كل طالبة تحاول تحل في كشكولة لحالها لو
+
+245
+00:22:43,850 --> 00:22:47,630
+سمحت كل
+
+246
+00:22:47,630 --> 00:22:52,090
+طالبة تحل لحالها السؤال الله بعينك يمسحينا
+
+247
+00:22:52,090 --> 00:23:05,690
+الصابورة مين
+
+248
+00:23:05,690 --> 00:23:14,090
+خلص حل السؤال؟عصر السرعة والله انا لسه بدي أدخل
+
+249
+00:23:14,090 --> 00:23:22,010
+شوية حبارة مين خلص سهل
+
+250
+00:23:22,010 --> 00:23:28,710
+مش صعب نعم
+
+251
+00:23:28,710 --> 00:23:32,710
+بنشوف
+
+252
+00:23:32,710 --> 00:23:35,670
+لغاية بتتغير السعر يعني
+
+253
+00:23:52,030 --> 00:23:54,790
+قداشي حكيتي عن الظقم يا وانتي؟
+
+254
+00:24:07,210 --> 00:24:12,690
+السعر هيدار زي ما هو يتغير؟ ماشي،
+
+255
+00:24:12,690 --> 00:24:25,670
+ما هو بنال عليه، بدي أشوف السعر أنا الاجمالة
+
+256
+00:24:25,670 --> 00:24:33,170
+تبع الانتاج، 6000 هو
+
+257
+00:24:33,170 --> 00:24:36,990
+بده يبيع للجدس أو للناس؟هيبعتوا لغدير لأنه غدير
+
+258
+00:24:36,990 --> 00:24:44,230
+حكت أن أنا من القدس؟ مين زي غدير من القدس؟ ما أنا
+
+259
+00:24:44,230 --> 00:24:52,850
+عارفة بس كلنا من القدس يعني مش احنا فاكنا فيها طب
+
+260
+00:24:52,850 --> 00:25:02,130
+مين منيافها؟ ما شاء الله ممتاز مين من تل الربيع؟
+
+261
+00:25:02,130 --> 00:25:05,290
+مش حلوة؟ مش معناه يعني
+
+262
+00:25:17,380 --> 00:25:28,340
+لأ احسبك .. احسبك لأ
+
+263
+00:25:28,340 --> 00:25:31,160
+احنا بنجيب الإجمالي و بعدين بنشوف العجز ..
+
+264
+00:25:31,160 --> 00:25:31,840
+الإجمالي
+
+265
+00:25:36,890 --> 00:25:41,350
+تلتلاف و خمسمية كدهش
+
+266
+00:25:41,350 --> 00:25:45,370
+المتبقى؟ ستلتلاف ناقص تلتلاف و خمسمية؟ تطلع خمسمية
+
+267
+00:25:45,370 --> 00:25:53,450
+ألفين و خمسمية ألفين و خمسمية لأ
+
+268
+00:25:53,450 --> 00:26:00,930
+ألفين و خمسمية و أنتي لا هان هان أيوة احتياجات تل
+
+269
+00:26:00,930 --> 00:26:04,690
+لظبيع احتياجات تل لظبيع
+
+270
+00:26:09,190 --> 00:26:13,090
+تل الظبيع .. تل الظبيع في السؤال
+
+271
+00:26:13,090 --> 00:26:36,270
+تلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلت
+
+272
+00:26:38,300 --> 00:26:42,200
+ممتازة يا عزيزي طب السعر هيتغير و لا يبقى لزمهو؟
+
+273
+00:26:42,200 --> 00:26:47,660
+تبعت للظبيع تحسبينا ياه و نستعين في صديقك، تفضلي
+
+274
+00:26:47,660 --> 00:27:00,880
+السعر؟ مين جاب السعر؟ ماشي خمسة، درع، عجز، تقسم،
+
+275
+00:27:00,880 --> 00:27:04,460
+احتاجاتها،
+
+276
+00:27:04,460 --> 00:27:05,340
+تلات تلات؟
+
+277
+00:27:08,250 --> 00:27:12,550
+خمسة في خمسمائة تلاف جيش بيعطينا خمسة .. خمسمانية
+
+278
+00:27:12,550 --> 00:27:14,970
+.. خمسمانية كده؟ تمانية .. تمانية .. تمانية ..
+
+279
+00:27:14,970 --> 00:27:17,670
+تمانية .. تمانية .. تمانية .. تمانية .. تمانية ..
+
+280
+00:27:17,670 --> 00:27:17,850
+تمانية .. تمانية .. تمانية .. تمانية .. تمانية ..
+
+281
+00:27:17,850 --> 00:27:17,890
+تمانية .. تمانية .. تمانية .. تمانية .. تمانية ..
+
+282
+00:27:17,890 --> 00:27:18,550
+تمانية .. تمانية .. تمانية .. تمانية .. تمانية ..
+
+283
+00:27:18,550 --> 00:27:19,990
+تمانية .. تمانية .. تمانية .. تمانية .. تمانية ..
+
+284
+00:27:19,990 --> 00:27:25,510
+تمانية .. تمانية .. تمانية .. تمانية .. تمانية ..
+
+285
+00:27:25,510 --> 00:27:27,410
+تمانية .. تمانية .. تمانية .. تمانية .. تمانية ..
+
+286
+00:27:27,410 --> 00:27:36,370
+تمانية .. تمانية .. تمان
+
+287
+00:27:37,330 --> 00:27:45,210
+لازم بجد الشعب برضه يحل بنفسه سهلة أه سهلة مش صعبة
+
+288
+00:27:45,210 --> 00:27:55,370
+يالا يا غادية الموازنة المفروض
+
+289
+00:27:55,370 --> 00:27:57,510
+يا جماعة أنتوا اللي هيكوا تحلوا لإنهم شرحوا الكلام
+
+290
+00:27:57,510 --> 00:28:02,590
+هذا مش جايبين تحلوا وازماتكم يالا يا أستاذة غادية
+
+291
+00:28:02,590 --> 00:28:05,030
+موازنت
+
+292
+00:28:07,770 --> 00:28:12,470
+لأ لأ لأ لأ لسه موازنة المبيعات حسب سياسة الشركة
+
+293
+00:28:12,470 --> 00:28:34,990
+احنا الساعة في واحد ماشي
+
+294
+00:28:34,990 --> 00:28:37,410
+الكمية السعر
+
+295
+00:28:39,180 --> 00:28:43,100
+الموازنة صح صح ما هو السعر الصغنون السعر الصغنون
+
+296
+00:28:43,100 --> 00:28:48,360
+أصلا مين خلص جدول الغدير؟ أنا ممتاز يا إسراء
+
+297
+00:28:48,360 --> 00:28:52,600
+البيان
+
+298
+00:28:52,600 --> 00:28:58,720
+اللي هي القدس يافة تل الربيع الصوت لو سمحته حلو و
+
+299
+00:28:58,720 --> 00:29:04,060
+بصمت سعر ال .. لا مش سعر القدس كمية القدس كدهش؟
+
+300
+00:29:04,060 --> 00:29:13,270
+ألف و خمسمية سعرها أربعةيافا ألفين سعرها ستة و نص
+
+301
+00:29:13,270 --> 00:29:21,510
+تل الربيع قدش قول نحن ابعته ألفين و خمسمية سعرها
+
+302
+00:29:21,510 --> 00:29:25,950
+خمسة point تمانى خمسة point تمانى اعطوها النواتج
+
+303
+00:29:25,950 --> 00:29:36,370
+لو سمحتوا آية أسرع طبعا
+
+304
+00:29:36,370 --> 00:29:44,930
+الدولارشكرا يا غديا تفضلي أسماء ال band التاني
+
+305
+00:29:44,930 --> 00:29:55,910
+هنعمل ال band التاني لمنطقة تل الربيع سووا القص
+
+306
+00:29:55,910 --> 00:29:59,790
+لحالك أنتوا بتدرعوا الحاجة السهلة تسوواها صح؟
+
+307
+00:30:07,140 --> 00:30:15,660
+هنسويها لتل الربيع لأ
+
+308
+00:30:15,660 --> 00:30:20,300
+بيحددلك منطقة عشان بياخد وجهتها ده عملها حسب فصول
+
+309
+00:30:20,300 --> 00:30:30,480
+السنة لمنطقة تل الربيع مثلا وخلاص هنتبه
+
+310
+00:30:30,480 --> 00:30:36,690
+نون؟ إيش نون عندك يا ألا سيد؟عشرة، تسعة، سبعة،
+
+311
+00:30:36,690 --> 00:30:40,150
+تسعة، تسعة، تسعة، تسعة، تسعة، تسعة، تسعة، تسعة،
+
+312
+00:30:40,150 --> 00:30:42,210
+تسعة، تسعة، تسعة، تسعة، تسعة، تسعة، تسعة، تسعة،
+
+313
+00:30:42,210 --> 00:30:46,310
+تسعة، تسعة، تسعة، تسعة، تسعة، تسعة،
+
+314
+00:30:46,310 --> 00:30:47,730
+تسعة، تسعة، تسعة، تسعة، تسعة، تسعة، تسعة، تسعة،
+
+315
+00:30:47,730 --> 00:30:47,750
+تسعة، تسعة، تسعة، تسعة، تسعة، تسعة، تسعة، تسعة،
+
+316
+00:30:47,750 --> 00:30:56,270
+تسعة، تسعة، تسعة، تسعة، تسعة، تسعة،
+
+317
+00:30:56,270 --> 00:31:02,870
+تسعة،
+
+318
+00:31:06,470 --> 00:31:17,470
+السعر قلنا خمسة point تمانية احنا
+
+319
+00:31:17,470 --> 00:31:22,530
+في تل الربيع يا أخوات لأن
+
+320
+00:31:22,530 --> 00:31:27,730
+احنا نبدأ نوزع لألف وخمسمية على أربع وترات مين
+
+321
+00:31:27,730 --> 00:31:33,450
+خلص؟ في ال hand مش الآن يا أسماء
+
+322
+00:31:41,950 --> 00:31:51,950
+تل الربيع؟ أيوة، هتساوي؟ ايوة،
+
+323
+00:31:51,950 --> 00:32:00,910
+ضرب؟ ممتاز، هتساوي؟ الفين و خمسمية؟
+
+324
+00:32:00,910 --> 00:32:04,570
+احنا في تل الربيع ولا شهر تلاتة؟ الفين و خمسمية؟
+
+325
+00:32:04,570 --> 00:32:06,410
+ضرب؟
+
+326
+00:32:09,280 --> 00:32:17,980
+تلاتة زيادة سبعة زيادة عشرة زيادة تسعة انا
+
+327
+00:32:17,980 --> 00:32:23,900
+حكيت الكمية الصغيرة يعني
+
+328
+00:32:23,900 --> 00:32:25,840
+مائتين و تسعة و خمسين يا نانتي هذه كميات مفهش
+
+329
+00:32:25,840 --> 00:32:32,540
+ابعتلهم ستة كيف ستة؟ بتقربوا يا أخوات إذا شهر
+
+330
+00:32:32,540 --> 00:32:37,600
+تلاتة هنبعتلهالنبعات موازمة .. نبعات موازمة ..
+
+331
+00:32:37,600 --> 00:32:42,920
+نبعات موازمة .. نبعات موازمة .. نبعات موازمة ..
+
+332
+00:32:42,920 --> 00:32:46,860
+نبعات موازمة .. نبعات موازمة .. نبعات موازمة ..
+
+333
+00:32:46,860 --> 00:32:48,120
+نبعات موازمة .. نبعات موازمة .. نبعات موازمة ..
+
+334
+00:32:48,120 --> 00:32:48,640
+نبعات موازمة .. نبعات موازمة .. نبعات موازمة ..
+
+335
+00:32:48,640 --> 00:32:50,540
+نبعات موازمة .. نبعات موازمة .. نبعات موازمة ..
+
+336
+00:32:50,540 --> 00:32:54,200
+نبعات موازمة .. نبعات موازمة .. نبعات موازمة ..
+
+337
+00:32:54,200 --> 00:33:01,640
+نبعات موازمة .. نبعات موازمة .. نبعات موازمة ..
+
+338
+00:33:01,640 --> 00:33:08,380
+نبعات موازمة .. نبعات مواز862 الحل صح و لا غلط
+
+339
+00:33:08,380 --> 00:33:13,180
+نجمعهم اجمعيهم اللي كتبتيهم توع الأرقام اللي
+
+340
+00:33:13,180 --> 00:33:17,140
+طلعتها تجمعيها للصغيرة اللي طلعت 2500 حلك صح طبعا
+
+341
+00:33:17,140 --> 00:33:20,780
+احنا عشان قربنا ممكن تطلع 2500 اشي مش مشكلة الان
+
+342
+00:33:20,780 --> 00:33:25,820
+هتبدأ تضبو في ايش؟ في السعر ايوة اضبونا لو سمحت
+
+343
+00:33:25,820 --> 00:33:30,660
+259 ضرب اه
+
+344
+00:33:30,660 --> 00:33:35,110
+دي مش مشكلة لو خلتي الرقم لأنه دي مصاريالموازنة
+
+345
+00:33:35,110 --> 00:33:40,030
+فلوس فلو ضال المقاربة عادي ألف و خمسمية و اتنين
+
+346
+00:33:40,030 --> 00:33:45,830
+ألف و خمسمية و اتنين ألف و خمسمية و اتنين ثم تلف
+
+347
+00:33:45,830 --> 00:33:48,490
+تلف و أربع تلف و سبعة و سبعة و نصفين و نصفين و
+
+348
+00:33:48,490 --> 00:33:51,550
+نصفين و نصفين و نصفين و نصفين و نصفين و نصفين و
+
+349
+00:33:51,550 --> 00:33:51,610
+نصفين و نصفين و نصفين و نصفين و نصفين و نصفين و
+
+350
+00:33:51,610 --> 00:33:53,270
+نصفين و نصفين و نصفين و نصفين و نصفين و نصفين و
+
+351
+00:34:10,040 --> 00:34:13,900
+تسعة و نصين تسعة و نصين تسعة و نصين تسعة و نصين
+
+352
+00:34:13,900 --> 00:34:15,560
+تسعة و نصين تسعة و نصين تسعة و نصين تسعة و نصين
+
+353
+00:34:15,560 --> 00:34:17,140
+تسعة و نصين تسعة و نصين تسعة و نصين تسعة و نصين
+
+354
+00:34:17,140 --> 00:34:17,780
+تسعة و نصين تسعة و نصين تسعة و نصين تسعة و نصين
+
+355
+00:34:17,780 --> 00:34:20,840
+تسعة و نصين تسعة و نصين تسعة و نصين تسعة و نصين
+
+356
+00:34:20,840 --> 00:34:22,880
+تسعة و نصين تسعة و نصين تسعة و نصين تسعة و نصين
+
+357
+00:34:22,880 --> 00:34:25,260
+تسعة و نصين تسعة و نصين تسعة و نصين تسعة و نصين
+
+358
+00:34:25,260 --> 00:34:37,300
+تسعة و نصين تسعة و نصين تسعة و نصين تسعة
+
+359
+00:34:37,300 --> 00:34:42,010
+و نصينهذا كان يا أخوات بالنسبة لموازنات المبيعات
+
+360
+00:34:42,010 --> 00:34:45,250
+هنبدأ
+
+361
+00:34:45,250 --> 00:34:47,750
+اليوم في الموازنة التانية في الموازنات التشغلية
+
+362
+00:34:47,750 --> 00:34:51,990
+اللي هي موازنات المخزون السلعي يلا يا أحلام
+
+363
+00:34:51,990 --> 00:34:52,510
+قرايرنا
+
+364
+00:34:58,240 --> 00:35:01,500
+بؤثر المخزون بشكل مباشر على حجم الإنتاج اللي لازم
+
+365
+00:35:01,500 --> 00:35:06,220
+يواجه المبيعات، تقونات المخزون السلعي، وحتاج تنمط
+
+366
+00:35:06,220 --> 00:35:09,900
+الصناع، وحتاج إنتاج تحت التشغيل، وحتاج مواد أولية،
+
+367
+00:35:09,900 --> 00:35:12,720
+العواصف اللي واصلة على المخزون السلعي، تكلفة
+
+368
+00:35:12,720 --> 00:35:15,040
+التنمط الصناعي، شوي شوي شوي شوي، إذا اننا أخوات
+
+369
+00:35:15,040 --> 00:35:17,700
+المخزون السلعي، خودي بالك المخزون عندنا أنواع،
+
+370
+00:35:17,700 --> 00:35:21,480
+عندنا هذا المخزون السلعي، اللي هو يعني مخزون سلعة
+
+371
+00:35:21,480 --> 00:35:28,100
+تنمط الصناعي، بيؤثر على حجم الإنتاج، كيف؟الان انا
+
+372
+00:35:28,100 --> 00:35:32,840
+طلبوا مني ليافة ألفين كرتونة يا أحلام، بروحش أعمل
+
+373
+00:35:32,840 --> 00:35:37,520
+ألفين كرتونة على طول أنتجها، لأ بروح المخزن، ضايل
+
+374
+00:35:37,520 --> 00:35:41,140
+بنطرح اللي ضايل و بنكمل الباقي، مش ضايل بنعمل
+
+375
+00:35:41,140 --> 00:35:46,220
+الألفين، إذا أنا طلبوا مني ليافة ألفين كرتونة،
+
+376
+00:35:46,220 --> 00:35:50,500
+بروحش عن الألفين، بروح المخزن، بفتحه، لجيت فيه 200
+
+377
+00:35:50,500 --> 00:35:55,690
+كرتونةقداش بساوي ضايل؟ الف وتمنمية الف وتمنمية زاد
+
+378
+00:35:55,690 --> 00:35:59,570
+المتل اللي جيناهم في النقزان هي الفلايافة واضح؟ ما
+
+379
+00:35:59,570 --> 00:36:02,030
+هي مقونات المخزون السلاحي؟ طبعا حسب المصنع إما
+
+380
+00:36:02,030 --> 00:36:06,710
+تامة الصنع أو تحت التشغيل لسه بدنا نشغل عليها أو
+
+381
+00:36:06,710 --> 00:36:11,570
+مواد خام ممكن يكون مخزون مواد خام أبسط عشان
+
+382
+00:36:11,570 --> 00:36:13,690
+العوامل المواطرة عن المخزون السلاحي بتاخدوها في
+
+383
+00:36:13,690 --> 00:36:17,690
+المخازن هذه تفضلي أحلى تكلفة التخزين وتكلفة الشراء
+
+384
+00:36:17,690 --> 00:36:20,810
+وندرة المواد وتوفير رأس المال العامل وسياسة الـ
+
+385
+00:36:21,140 --> 00:36:25,180
+وسياسة الإدارة ممتاز في حاجة أخدتوها برضه في
+
+386
+00:36:25,180 --> 00:36:28,660
+المخازن و أخدتوها في الإدارة المالية اللي هي
+
+387
+00:36:28,660 --> 00:36:33,820
+الكمية الاقتصادية للجدر تربيعي هداك للمخزون تفضلي
+
+388
+00:36:33,820 --> 00:36:38,040
+أحلى الحجم العكسي للمخزون هو ذلك الحجم اللي ..
+
+389
+00:36:38,040 --> 00:36:41,500
+اللي بتحفظ عنده التكاليف الإجمالي للمخزون الأدنى
+
+390
+00:36:41,500 --> 00:36:44,640
+حد ممكن الحجم اللي بنحققه عنده أقل تكاليف ممكنة
+
+391
+00:36:44,640 --> 00:36:47,740
+بنسميه الحجم الأمتل للمخزون مش موضوعنا في المساقى
+
+392
+00:36:47,740 --> 00:36:51,920
+هذا شكرا يا أحلىأه يا سمون ادخل يا نوع تكاليف
+
+393
+00:36:51,920 --> 00:36:57,660
+المخزون ببساطة
+
+394
+00:36:57,660 --> 00:37:00,460
+يا أخوتي يعني بدل ما ندفع مصارف المخازن كممكن ندفع
+
+395
+00:37:00,460 --> 00:37:04,840
+المصارف أيش تاني؟ ليه الفرصة الفديلة؟ اتنين؟ اللي
+
+396
+00:37:04,840 --> 00:37:07,800
+هي التبريد ده؟ جبت حرارة انحارس المي الكهرة
+
+397
+00:37:07,800 --> 00:37:14,490
+بالتليفون تبعت المخازن؟أنا عندي 200 كرتونة لما
+
+398
+00:37:14,490 --> 00:37:17,950
+جينا انطلهم لجينا في منهم الميه داخل عليه مخرباه
+
+399
+00:37:17,950 --> 00:37:23,370
+لو طحين الفارق داخل عليه و هكذا شكرا يا آية، مسوس
+
+400
+00:37:23,370 --> 00:37:26,450
+مثلا هنادر شاصي ما هي هداف سياسة المخزون السلعي
+
+401
+00:37:26,450 --> 00:37:29,670
+الحجم الاقتصادي الأكثر من المخزون اللي دي سيادات
+
+402
+00:37:29,670 --> 00:37:32,090
+تبع عليه تحديد مواعي الإنتاج والكمية
+
+403
+00:37:37,790 --> 00:37:40,950
+إذا الحجم الاقتصادي طبعا حكيناها للمخزون بترتب
+
+404
+00:37:40,950 --> 00:37:45,510
+عليه تحديد مواعيد الإنتاج وإيش وكمياته بمعنى طول
+
+405
+00:37:45,510 --> 00:37:50,010
+ما المخازن فيها إبضاع بشغلش أنا مابضلش هاندج جربت
+
+406
+00:37:50,010 --> 00:37:52,990
+لخلص أشمالنا إبن انتج يعني مابضلش أكدس إبضاع في
+
+407
+00:37:52,990 --> 00:37:57,250
+المخازن المشكلة هذه مخزون تكلفة أيوة شكرا يا هنادي
+
+408
+00:37:57,250 --> 00:38:00,970
+الساعة شغل مرمية نوع التكلفة اللي تحتاج ليها هدا
+
+409
+00:38:00,970 --> 00:38:02,030
+تحديد الحكم اقتصاد المخزون
+
+410
+00:38:07,470 --> 00:38:13,890
+لأ يا رجل احنا خلصناه انت ترجع ترجع
+
+411
+00:38:20,770 --> 00:38:24,130
+أه يا سامونو هنادي خليكم معانا تكلفة فرص المدينة
+
+412
+00:38:24,130 --> 00:38:40,090
+شرحناها تكلفة المتافع للشراء شكرا
+
+413
+00:38:40,090 --> 00:38:45,090
+يا عزيزي فيه ما يوحدة مش واضحة أشرحها أي دلال فيه
+
+414
+00:38:45,090 --> 00:38:50,940
+ما يتكلف أشرحها فيه ما يتكلف أشرحهاهناخد اليوم
+
+415
+00:38:50,940 --> 00:38:53,180
+القانون ونحل السؤال المحاضرة القادمة إن شاء الله
+
+416
+00:38:53,180 --> 00:38:57,080
+لأنه بندوقة جدا سماعة أبو دقة ما هو موضوع أو وضحي
+
+417
+00:38:57,080 --> 00:39:02,480
+بالرسم معلش سماعة أبو جامع موقع موازنة مخزون السلع
+
+418
+00:39:02,480 --> 00:39:07,560
+من الموازنات أول حاجة لازم يكون عندك موازنة
+
+419
+00:39:07,560 --> 00:39:13,000
+المبيعات خدي بالك احنا بنخزن وحدات مش دولارات
+
+420
+00:39:13,000 --> 00:39:16,440
+فلازم تكون المبيعات بالوحدات لو حلتيها الدولار
+
+421
+00:39:16,440 --> 00:39:21,630
+السؤال كله غلطانعيد مرة تانية يا أحلام موازنة
+
+422
+00:39:21,630 --> 00:39:25,630
+المبيعات هان حكينا المحاضرة الماضية نوعين إما
+
+423
+00:39:25,630 --> 00:39:29,470
+دولار أو وحدة لو أنا بدأ أجيب موازنة المخزون لازم
+
+424
+00:39:29,470 --> 00:39:33,710
+أكون عند المبيعات بالوحدة مانفعش أنحلها الدولارات
+
+425
+00:39:33,710 --> 00:39:36,390
+معناه إحنا مانخزن دولارات إحنا مانخزنش دولارات
+
+426
+00:39:36,390 --> 00:39:39,990
+إحنا مانخزن أمضاعة قاعدين فاخد بالك لو حلت السؤال
+
+427
+00:39:39,990 --> 00:39:43,750
+عن موازنة المبيعات بالوحدة كله غلط معناه الحمد لله
+
+428
+00:39:43,750 --> 00:39:48,910
+مش هالمحاجة فأيوة يا سماحبناءً عن المبيعات بقدر
+
+429
+00:39:48,910 --> 00:39:53,470
+أعمل مقصود أصطلاعي و بعد ذلك الأش الانتاج شكرا
+
+430
+00:39:53,470 --> 00:39:58,650
+أنتي هنقرأ السؤال و نحن المحاضرة الجاية يتفضلي يا
+
+431
+00:39:58,650 --> 00:40:03,070
+نون عمارة موزمة مقصود أصطلاعي أقول المثال ولا بس
+
+432
+00:40:03,070 --> 00:40:08,670
+القانون؟ هنقرأ اقرأ المثال هنقرأ السؤال مثل شركة
+
+433
+00:40:08,670 --> 00:40:12,730
+فجر سياستها في المقصود أصطلاعي لاتقل عن 25% خط خط
+
+434
+00:40:15,640 --> 00:40:18,760
+أيوة؟ مبيعات الشهر التالي المطلوب إعداد موازنة
+
+435
+00:40:18,760 --> 00:40:22,860
+المخزون السلعي لتلات شهور إذا في حاجة ناقصة في
+
+436
+00:40:22,860 --> 00:40:28,660
+السؤال لتلات شهور كملوا معايا لو سمحتوا السؤال
+
+437
+00:40:28,660 --> 00:40:35,780
+ناقصان وكانت المبيعات كالقاتى
+
+438
+00:40:35,780 --> 00:40:43,100
+وكانت المبيعات كالقاتى هتروح رسمة جدول من تلات
+
+439
+00:40:43,100 --> 00:40:43,520
+أعمدة
+
+440
+00:40:47,230 --> 00:40:52,370
+كاتبة فيه noon العمود الأول الكمية اللي هي كمية
+
+441
+00:40:52,370 --> 00:40:56,930
+النبع طبعا العمود التاني والسعر العمود التالت
+
+442
+00:40:56,930 --> 00:41:03,090
+السعر ثابت عشرين عشرين عشرين السعر عشرين عشرين
+
+443
+00:41:03,090 --> 00:41:08,830
+عشرين عشرين أربع مرات لعشرين noon اللي هي الأشهر
+
+444
+00:41:08,830 --> 00:41:13,650
+واحد اتنين تلات أربع noon واحد اتنين تلات أربع
+
+445
+00:41:13,650 --> 00:41:21,970
+الكمية كانت الشهر الأول الفينالشهر التاني ست آلاف،
+
+446
+00:41:21,970 --> 00:41:27,790
+الشهر التالت خمس آلاف، الشهر الرابع أربع آلاف،
+
+447
+00:41:27,790 --> 00:41:33,490
+هأجي السؤال، أعد موازنة المخزون لتلات إيش؟ أشهر،
+
+448
+00:41:33,490 --> 00:41:38,710
+هنحن من المحاضرة القادمة، أخر حاجة، إيش القانون
+
+449
+00:41:38,710 --> 00:41:39,650
+اللي بنمشي عليه؟
+
+450
+00:41:43,080 --> 00:41:47,640
+مبيعاتنا في نسبة لمخزون، من حلل المحاضرات القادمة،
+
+451
+00:41:47,640 --> 00:41:52,900
+في أي سؤال أو سفسار؟ أي سؤال؟ أي سؤال؟ يعطيكوا
+
+452
+00:41:52,900 --> 00:41:53,260
+العافية
+
diff --git a/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/yOyAN8R9VNs_raw.srt b/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/yOyAN8R9VNs_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..8546a351e75258a2d998568156fc61ec5a48f240
--- /dev/null
+++ b/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/yOyAN8R9VNs_raw.srt
@@ -0,0 +1,1824 @@
+1
+00:00:20,920 --> 00:00:23,400
+اعودوا بالله السميع العليم من الشيطان الرجيم بسم
+
+2
+00:00:23,400 --> 00:00:26,620
+الله الرحمن الرحيم الحمد لله والصلاة والسلام على
+
+3
+00:00:26,620 --> 00:00:31,320
+المصطفى الأمين سيدنا محمد وعلى آله ومن ساره على
+
+4
+00:00:31,320 --> 00:00:34,100
+دربي بحسن اليوم الدنيا في بداية السلام عليكم ورحمة
+
+5
+00:00:34,100 --> 00:00:38,480
+الله كيف حالكم؟ كيف أصبحتوا اليوم كويسين ان شاء
+
+6
+00:00:38,480 --> 00:00:44,720
+الله؟مازلنا في المحاضرة التانية في موضوع الموازنات
+
+7
+00:00:44,720 --> 00:00:49,540
+التشغيلية، تعرفنا عليها المحاضرة الماضية وميزنا
+
+8
+00:00:49,540 --> 00:00:55,400
+بينها و بين الموازنات الرئيس مالية، بعدين تعرفنا
+
+9
+00:00:55,400 --> 00:00:58,260
+على أقسامها وحكينا إن حجر الأساس إيه اللي هو
+
+10
+00:00:58,260 --> 00:01:03,860
+المبيعات، من غير مبيعات أنا ما بقدر أتصرف، من غير
+
+11
+00:01:03,860 --> 00:01:09,610
+مبيعات إحنا إشملنا، ماقدر نتصرفالماضي الماضي بدينا
+
+12
+00:01:09,610 --> 00:01:19,270
+بيه اللي هو موازنة المبيعات تعرفنا عليها خدنا
+
+13
+00:01:19,270 --> 00:01:24,230
+سؤالين اليوم هنكمل هذا
+
+14
+00:01:24,230 --> 00:01:33,890
+كله اتطلقناله حلنا السؤال هذا و هذا حلناه عندنا
+
+15
+00:01:33,890 --> 00:01:40,110
+السؤال هذا example 3 او example threeتفضلي أخت
+
+16
+00:01:40,110 --> 00:01:46,450
+كفاية قراينا سؤال لدى شركة الفن لصناعة السابون
+
+17
+00:01:46,450 --> 00:01:52,510
+ثلاث مناطق القدس، عكا، ناصر، ناصر في عنا شركة
+
+18
+00:01:52,510 --> 00:01:57,850
+بتصنع السابونة بتوزع هي تلت مناطق الناصرة والقدس
+
+19
+00:01:57,850 --> 00:02:03,290
+عكا والقدس وبعد دراسة الصفوة تنبؤ بالكميات
+
+20
+00:02:03,290 --> 00:02:08,090
+والاسعار اتضح الاسم بالنسبة للناصرة الناصرة جداش
+
+21
+00:02:08,090 --> 00:02:08,650
+بتبعت
+
+22
+00:02:14,040 --> 00:02:19,720
+الناصرة تستوعب أربعتاشر ألف كرتون سابون، ممكن نقول
+
+23
+00:02:19,720 --> 00:02:24,640
+كرتونها تلاتة و خمسين، عكّة؟ أربعتاشر ألف عكّة،
+
+24
+00:02:24,640 --> 00:02:30,060
+السعر خمسين، والكمية عشر تلاف .. بنبعت لعكّة عشر
+
+25
+00:02:30,060 --> 00:02:35,440
+تلاف و خمسين دولار، القدس؟ السعر تمانية و أربعين،
+
+26
+00:02:35,440 --> 00:02:38,080
+والكمية سبعتاشر ألف .. نبعتلها سبعتاشر ألف تمانية
+
+27
+00:02:38,080 --> 00:02:43,030
+و أربعين، طيبالشركة لا تستطيع الوفاة بما يديد عن
+
+28
+00:02:43,030 --> 00:02:47,850
+أربعين ألف واحدة من المرتبط الشركة الطاقة القصوى
+
+29
+00:02:47,850 --> 00:02:51,990
+لإنتاج الصابون في شركة الفجر فقط أربعين ألف واحدة
+
+30
+00:02:51,990 --> 00:02:56,610
+وكانت سياسة الشركة كاملةإذا نحط خط تحت كلمة سياسة
+
+31
+00:02:56,610 --> 00:03:00,370
+الشركة، إيش سياسة الشركة؟ الوفاء باحتياجات من
+
+32
+00:03:00,370 --> 00:03:04,770
+منطقة القدس والناصرة من المصنع بأبعد للقدس من ال
+
+33
+00:03:04,770 --> 00:03:09,730
+40 ألف اللي في المصنع و بعدين الناصرة و نضل حاجة
+
+34
+00:03:09,730 --> 00:03:14,770
+لعكة، اه يمكن العكة ما يضلش و يمكن يضل مش عارفين و
+
+35
+00:03:14,770 --> 00:03:18,950
+تبلغ معدلات بيع المنتج خلال فصول السنة نانو ستة و
+
+36
+00:03:18,950 --> 00:03:22,940
+خمسة أربعةيعني هدى يا أخوات فى شهر اتنين بتفع
+
+37
+00:03:22,940 --> 00:03:25,900
+الطلب فى شهر ستة فى شهر خمسة فى شهر أربعة تعدى
+
+38
+00:03:25,900 --> 00:03:29,840
+موازنة المبيعات حسب سياسات الشركة وحسب كل فصل من
+
+39
+00:03:29,840 --> 00:03:32,500
+فصوله شكرا يانت مطلوب مننا شغلتين أول حاجة
+
+40
+00:03:32,500 --> 00:03:37,620
+الموازنة حسب سياسة الشركة بعدين الموازنة حسب فصول
+
+41
+00:03:37,620 --> 00:03:44,780
+السنة تعالوا نبدأ انحل شوية شوية فانحنقول مع بعض
+
+42
+00:03:44,780 --> 00:03:52,870
+ركزوا معانا لو سمحتواواحد الموازنة بموازنة نبعات
+
+43
+00:03:52,870 --> 00:04:01,170
+حسب سياسة الشركة انطلع سياسة الشركة من السؤال
+
+44
+00:04:01,170 --> 00:04:13,350
+الجزء
+
+45
+00:04:13,350 --> 00:04:17,810
+الكلي او اللي هو الاحتياجات زي ما احنا عايزينخلّي
+
+46
+00:04:17,810 --> 00:04:25,530
+الاحتياجات هادي نبدأ
+
+47
+00:04:25,530 --> 00:04:36,610
+مع بعض أول حاجة قداش حجم إنتاج المصنع أربعين ألف،
+
+48
+00:04:36,610 --> 00:04:41,570
+أربعين ألف إذا قداش حجم إنتاج المصنع أربعين ألف،
+
+49
+00:04:41,570 --> 00:04:46,270
+لو أننا جيبناها مطنية في سوق، لأي منطقة بودوا جبل؟
+
+50
+00:04:48,290 --> 00:04:54,410
+احتياجات القدس؟ قداش القدس بتحتاج؟ اربعتاشر ألف
+
+51
+00:04:54,410 --> 00:04:58,670
+بعد
+
+52
+00:04:58,670 --> 00:05:04,410
+القدس خلاص و لا في حد؟ في الناصرة الناصرة اربعتاشر
+
+53
+00:05:04,410 --> 00:05:11,450
+اربع .. الناصر اربعتاشر الف اجمالي
+
+54
+00:05:11,450 --> 00:05:17,210
+الاحتياجات؟ سبعتاشر
+
+55
+00:05:17,210 --> 00:05:17,930
+لدى اربعتاشر
+
+56
+00:05:25,180 --> 00:05:30,360
+في حد بيسأل نفسه من أين جابوها؟ إذا أنا عندي
+
+57
+00:05:30,360 --> 00:05:35,140
+أربعين ألف كرتون سابون لما أبعت للقدس والناصرة
+
+58
+00:05:35,140 --> 00:05:40,960
+احتياجاتهم بيضل عندنا مين؟ واحد و تلاتين ألف ضل
+
+59
+00:05:40,960 --> 00:05:51,180
+عندنا منطقة عكا احتياجات عكاقداش عد كم احتاجة؟
+
+60
+00:05:51,180 --> 00:05:59,440
+عشرة تلاف عشرة تلاف قداش
+
+61
+00:05:59,440 --> 00:06:06,120
+عد كم احتاجة؟ عشرة تلاف احسبي لو سمحتي أربعين ناقص
+
+62
+00:06:06,120 --> 00:06:13,920
+واحد تلاتين ستة ألف ممكن نحطه هان المتبقي
+
+63
+00:06:20,550 --> 00:06:23,010
+إذا إحنا بعد ما نوزع القدس و الناس، قداش بيظل
+
+64
+00:06:23,010 --> 00:06:27,190
+عندنا؟ تسعة تلات، عكى قداش بدها؟ عشرة تلات عندنا
+
+65
+00:06:27,190 --> 00:06:35,130
+عاجز ولا فائض؟ عاجز ألف أعيدها؟
+
+66
+00:06:35,130 --> 00:06:40,810
+حاضر يعني، الآن أنا عندي في المصنع أربع وعشرين
+
+67
+00:06:40,810 --> 00:06:46,650
+ألف، عفوا، أربعين ألف صندوق صابون، بعثنا للقدس
+
+68
+00:06:46,650 --> 00:06:52,340
+حصتهم حسب السؤال سبعتاشر ألفو بعدين بعتنا للناصرة
+
+69
+00:06:52,340 --> 00:06:57,320
+حصتها 14 ألف ممكن طالبة بتحكي شمال القدس والناصرة
+
+70
+00:06:57,320 --> 00:07:00,640
+جابل أشمش عكّة لأن هو في السورة حاكمني قايدني في
+
+71
+00:07:00,640 --> 00:07:04,320
+السورة لما بعتنا للقدس والناصرة طلعوا أجمعي اللي
+
+72
+00:07:04,320 --> 00:07:13,020
+بعتناه 31 ألف ليه 17 زي 14 40 ألف كله مع بعض ناقص
+
+73
+00:07:13,020 --> 00:07:20,080
+31 بعتناه مجدش غايل 9000 مجدش احتياجات عكّة 10000
+
+74
+00:07:21,140 --> 00:07:25,460
+هل هابعت لعكة لعشرة تلاف ولا ماضلش عندي؟ هبعدلها
+
+75
+00:07:25,460 --> 00:07:29,080
+التسعة ويكون عندنا عاجز، الألف، من ورا الألف،
+
+76
+00:07:29,080 --> 00:07:32,740
+العكة تدبر حالها عاد، مش احنا، الألف العاجز احنا
+
+77
+00:07:32,740 --> 00:07:36,140
+قلنا فيهم لأ، هدولة العكة هي تدبر حالها، تجيبها من
+
+78
+00:07:36,140 --> 00:07:43,020
+مصنع تاني، هي حلوة، أعيدهم تاني؟ فضلي، إذا أنا
+
+79
+00:07:43,020 --> 00:07:50,260
+عندي في المصنع أربعين ألف كرتونة كولة، ماشي؟حسب
+
+80
+00:07:50,260 --> 00:07:55,080
+سياسة المؤسسة، بابعت للقدس حصتها من الرابعين ألف،
+
+81
+00:07:55,080 --> 00:07:59,320
+اللي سبعتاشر ألف، و بعدين بابعت للناصر حصتها ليه
+
+82
+00:07:59,320 --> 00:08:04,340
+قداشر؟ أربعتاشر، إذا بابعت للقدس و للناصر، عاد كأن
+
+83
+00:08:04,340 --> 00:08:08,760
+ضال حاجة من المنتج بنبعته، ماضلش خلاص يعني
+
+84
+00:08:08,760 --> 00:08:15,560
+المنافسينبعتنا سبعتاش واربعتاش لما جمعناهم سبعتاش
+
+85
+00:08:15,560 --> 00:08:19,220
+ألف زي الاربعتاش قدش طلع؟ واحد تلاتين ألف، احسبيه
+
+86
+00:08:19,220 --> 00:08:26,240
+لواحد
+
+87
+00:08:26,240 --> 00:08:30,720
+تلاتين ألف إجمالي مش جزءي، القدس والناصر هدول
+
+88
+00:08:30,720 --> 00:08:36,020
+جزييات، بينما المصنع بيكون كل شغل إجماليواحد و
+
+89
+00:08:36,020 --> 00:08:42,240
+تلاتين ألف طيب أربعين ألف علبة كولا وزقت منها واحد
+
+90
+00:08:42,240 --> 00:08:48,400
+و تلاتين جداش ضايل تسعة نيجي على أكا جداش أكا
+
+91
+00:08:48,400 --> 00:08:53,880
+بدكوا بدنا عشرة ألف احنا ماعناش غير تسعة جداش
+
+92
+00:08:53,880 --> 00:09:00,440
+العجل صار عشرة ألف ناقص أسعة ألف ألف أعيدها أعيدها
+
+93
+00:09:00,440 --> 00:09:06,910
+تاني أعيدها أعيدها مش مشكلة أعيدهاإن شاء الله.
+
+94
+00:09:07,510 --> 00:09:14,070
+الآن يا أخوات كنا متفقين مع عكا إذا بعتنا لهم
+
+95
+00:09:14,070 --> 00:09:22,430
+العشر تلاف جداش السعر؟ السؤال؟ طلب السرخانة عكا
+
+96
+00:09:22,430 --> 00:09:25,650
+كنا متفقين حسب السؤال إذا أنا بعتلهم عشر تلاف
+
+97
+00:09:25,650 --> 00:09:30,970
+كرتونة يكونوا بخمسين لكن الآن أنا ما راح أبعت عشر
+
+98
+00:09:30,970 --> 00:09:38,560
+تلاف راح أبعت جداش تسعة تلافالسعر لازم يتغير إذا
+
+99
+00:09:38,560 --> 00:09:44,780
+بما أنه ظهر عندنا عجز تسعة آلاف يا أحلام مش هنضلنا
+
+100
+00:09:44,780 --> 00:09:48,240
+على الخمسين إيش الخمسين؟ السعر أنا بحكي عن عكة
+
+101
+00:09:48,240 --> 00:09:50,640
+مالاش إلا قداجي ماعندهوش مشاكل عكة اللي عندها
+
+102
+00:09:50,640 --> 00:10:01,100
+مشاكل الآن السعر هيتغير في حالة انخفاض العرض إيش
+
+103
+00:10:01,100 --> 00:10:06,380
+بيصير في السعر؟ ب zero ولا بقل؟بزيه .. بزيه ..
+
+104
+00:10:06,380 --> 00:10:11,340
+بزيه .. بزيه .. بزيه .. بزيه .. بزيه .. بزيه ..
+
+105
+00:10:11,340 --> 00:10:15,100
+بزيه .. بزيه .. بزيه .. بزيه .. بزيه .. بزيه ..
+
+106
+00:10:15,100 --> 00:10:15,860
+بزيه .. بزيه .. بزيه .. بزيه .. بزيه .. بزيه ..
+
+107
+00:10:15,860 --> 00:10:15,960
+بزيه .. بزيه .. بزيه .. بزيه .. بزيه .. بزيه ..
+
+108
+00:10:15,960 --> 00:10:16,740
+بزيه .. بزيه .. بزيه .. بزيه .. بزيه .. بزيه ..
+
+109
+00:10:16,740 --> 00:10:18,400
+بزيه .. بزيه .. بزيه .. بزيه .. بزيه .. بزيه ..
+
+110
+00:10:18,400 --> 00:10:22,760
+بزيه .. بزيه .. بزيه
+
+111
+00:10:22,760 --> 00:10:26,060
+.. بزيه
+
+112
+00:10:26,060 --> 00:10:32,310
+.. بزيه .. بزيه .. بزيهخودي بالك لغاية الآن احنا
+
+113
+00:10:32,310 --> 00:10:35,110
+ماتجيبناش الموازنة لغاية الآن احنا جاعدين بنشوف
+
+114
+00:10:35,110 --> 00:10:39,390
+إيش بتصير في المنتج و كده إيش هنبعد هنقول مع بعض
+
+115
+00:10:39,390 --> 00:10:48,410
+هان سيتغير يتغير
+
+116
+00:10:48,410 --> 00:10:58,730
+سعر مدينة عكا و ذلك لووجود عجز
+
+117
+00:11:00,450 --> 00:11:08,070
+جدّاش السعر يا أخوات؟ السعر القديم ضرب نسبة العجز
+
+118
+00:11:08,070 --> 00:11:15,310
+زاد السعر القديم بساوة جدّاش سعرنا القديم في
+
+119
+00:11:15,310 --> 00:11:21,750
+السؤال اللي عكّى؟ خمسين جدّاش نسبة العجز؟ ألف
+
+120
+00:11:21,750 --> 00:11:27,010
+تقسيم عشرة تلاف اللي هو المطلوب إذا المين هذا
+
+121
+00:11:27,010 --> 00:11:29,650
+العجز؟ هو هذا الإجمال المطلوب زاد خمسين
+
+122
+00:11:33,160 --> 00:11:39,040
+عكتبها على طول يعني ولا كتب خمسة زائد خمسين؟
+
+123
+00:11:39,040 --> 00:11:44,920
+إذا إيه جداش سعر عكسها؟ مش خمسين مش زي السؤال،
+
+124
+00:11:44,920 --> 00:11:47,840
+ليش؟ لأنه فيه عجز، إيش يعني عجز؟ يعني انخفاض
+
+125
+00:11:47,840 --> 00:11:50,640
+العرض، إيش يعني انخفاض العرض؟ يعني زيادة السعة
+
+126
+00:11:50,640 --> 00:11:57,300
+واضح ليش القدس والناس اللي دلوا زي ما هم بينما عكة
+
+127
+00:11:57,300 --> 00:12:01,560
+هي اللي غيرنا عليها أمسح؟
+
+128
+00:12:04,900 --> 00:12:10,600
+واضحة ولا عيدها؟ عيدها؟ كأنه احنا بنطلع الخلل تبع
+
+129
+00:12:10,600 --> 00:12:15,420
+الألف في السعة نفسه عشان ما نخسرش معايا ولا صعب؟
+
+130
+00:12:15,420 --> 00:12:22,580
+سهلة؟ او سهل؟ ان انا بنجيب الموازن زي ما تعودنا؟
+
+131
+00:12:41,960 --> 00:12:48,860
+القدس، الناصرة، عكا قداش
+
+132
+00:12:48,860 --> 00:12:56,300
+غدير مبيعات القدس بالوحدة قداش سعرها؟ ماتغيرش،
+
+133
+00:12:56,300 --> 00:13:03,750
+مافيش مشاكل في القدس، الناصرة سعرها 53عاكر قداشة
+
+134
+00:13:03,750 --> 00:13:07,350
+حنبقت لها؟ تسعة للالات تسعة و خمسة و خمسية همتاز
+
+135
+00:13:07,350 --> 00:13:10,770
+هذا بس التغيير طبعا درب هذا يا أخوتي يا أخواتي هذا
+
+136
+00:13:10,770 --> 00:13:18,090
+درب أضربيه سبعتاشر الف تمانية و أربعين طبعا
+
+137
+00:13:18,090 --> 00:13:22,190
+ساعتها اندولار هدي واحدة سبعمية و كيلو أرويه
+
+138
+00:13:22,190 --> 00:13:29,090
+أربعين أربعين أربعين و خمسة و خمسين ممكن
+
+139
+00:13:29,090 --> 00:13:31,330
+نجيب الإجمالي مش مشكلة ممكن نجيبه عادي
+
+140
+00:13:34,860 --> 00:13:39,160
+في حد عنده مشكلة؟ في حد بيقول من وين جابوا الحاجات
+
+141
+00:13:39,160 --> 00:13:44,160
+هذه؟ أعيد تاني، إذا الحاجة البسيطة اللي فيها مشكلة
+
+142
+00:13:44,160 --> 00:13:52,000
+كانت إن عكا صار عندها خلل صار عندها إيش؟ عجز إذا
+
+143
+00:13:52,000 --> 00:13:54,600
+هذا كان المطلوب الأول في السؤال، احسب موازنة
+
+144
+00:13:54,600 --> 00:14:00,180
+المبيعات حسب السياسة السياسة كانت اللي هي القدس
+
+145
+00:14:00,180 --> 00:14:03,160
+الناصر عكا، المطلوب التاني
+
+146
+00:14:06,500 --> 00:14:10,900
+احسب الموازنة حسب كل فصل من فصول السنة ماعطينا
+
+147
+00:14:10,900 --> 00:14:15,060
+اتنين، ستة، خمسة، اربعة هنعملها للقدس وانتوا
+
+148
+00:14:15,060 --> 00:14:26,420
+بتكملوا في البيت لباقية المناطق أمسة؟ عاوزة تجمس؟
+
+149
+00:14:26,420 --> 00:14:29,840
+خلاص؟
+
+150
+00:14:29,840 --> 00:14:33,660
+اه ممكن تطلع إيادة صح أمسة؟
+
+151
+00:14:36,570 --> 00:14:41,750
+إذا الأول إيش هنجيب؟ ماشي ممتاز، اللي هو المطلوب
+
+152
+00:14:41,750 --> 00:14:45,790
+التاني في الساعة هنقول
+
+153
+00:14:45,790 --> 00:14:51,970
+الموازنة لمنطقة
+
+154
+00:14:51,970 --> 00:14:57,310
+القدس لمنطقة
+
+155
+00:14:57,310 --> 00:15:07,040
+القدس حسب فصول السنةإذا إيش هنجيب الآن؟ الموازنة
+
+156
+00:15:07,040 --> 00:15:12,080
+حسب فصول السنة بس القُلص، ماشي؟ بس الشهر .. السفر
+
+157
+00:15:12,080 --> 00:15:15,220
+اللي قبل اللي هو هذا اللي هو ده اتنين، ستة، خمسة،
+
+158
+00:15:15,220 --> 00:15:20,320
+أربعة، و هذا الفصول اللي هو النوم، شهور يعني؟
+
+159
+00:15:20,320 --> 00:15:25,370
+ممكن، بس نكتبها بالترتيب أفضل يا جماعةممكن شهور،
+
+160
+00:15:25,370 --> 00:15:27,890
+ممكن أنه في فصل الربيع أو في فصل الشتاء، هذا
+
+161
+00:15:27,890 --> 00:15:32,010
+بيطلع، بنركز عليه، فصل الربيع، فصل الربيع برضه
+
+162
+00:15:32,010 --> 00:15:37,130
+هذا، فصل الصيف أو هذا الخريف ممكن يكون سواء فصول
+
+163
+00:15:37,130 --> 00:15:41,730
+أو شهور، نفس الحالة المبيعات بالوحدة، خودي بالك
+
+164
+00:15:41,730 --> 00:15:45,630
+للقدس بس السعر
+
+165
+00:15:45,630 --> 00:15:48,850
+الموازنة
+
+166
+00:15:48,850 --> 00:15:53,030
+نوم كتبناها، بيطلع في السؤال، اللي هي الفترة
+
+167
+00:15:53,030 --> 00:15:59,150
+الزمنيةقداش سعر منطقة القدس؟
+
+168
+00:15:59,150 --> 00:16:05,750
+تاخدنا مليون و أربعين ماعطيكي أفى سؤال بس
+
+169
+00:16:05,750 --> 00:16:09,590
+لقدس هجيب المبيعات
+
+170
+00:16:09,590 --> 00:16:14,850
+بإيش؟ بالوحدة كيف
+
+171
+00:16:14,850 --> 00:16:18,950
+هنجيبها؟ هده يا أخوات؟ هجيبها كلها أربع تاشر ألف
+
+172
+00:16:18,950 --> 00:16:23,970
+مفهوش لإنه أربع تاشر .. سبعتاشر يعنيهذه كانت ناصرة
+
+173
+00:16:23,970 --> 00:16:27,790
+انت من الناصرة ولا من وين؟ انا من القدس ماشي منيح
+
+174
+00:16:27,790 --> 00:16:33,070
+ان شاء الله نصلي مع بعض هناك منفعش
+
+175
+00:16:33,070 --> 00:16:37,110
+اقول سبعتاشر تمانية واربعين غلطتك لازم نوزعهم خدي
+
+176
+00:16:37,110 --> 00:16:42,950
+بالك هنقول مبيعات .. هاي الحالة هدهامش يا أخوات
+
+177
+00:16:42,950 --> 00:16:47,830
+ماجيش معاك جدول مبيعات القدس هتساوي؟
+
+178
+00:16:49,110 --> 00:16:54,390
+مبيعات القدس لكل شهر أو لكل فترة، حتساوي؟ المبيعات
+
+179
+00:16:54,390 --> 00:17:02,830
+ضرب الشهر ع الإجمالي كاف يعني، تعالي نطبق مبيعات
+
+180
+00:17:02,830 --> 00:17:08,990
+القدس لشهر اتنين، حتساوي؟ سبعتاشر الف .. سبعتاشر
+
+181
+00:17:08,990 --> 00:17:14,330
+الف في اتنين على ضرب، احنا في شهر اتنين، اتنين
+
+182
+00:17:14,330 --> 00:17:17,370
+هيكون قاعد فوق في ال bus ع الإجمالي اللي هو اتنين
+
+183
+00:17:18,330 --> 00:17:25,830
+زائد شهر أربعة زائد خمسة زائد ستة، إذا سهلة تطلع
+
+184
+00:17:25,830 --> 00:17:29,710
+ألفين، لازم يا أخوات يطلع رقم صغنون، مش صغنون على
+
+185
+00:17:29,710 --> 00:17:34,610
+الآخر، منطقي يعني، إيش يعني ألفين؟ يعني من
+
+186
+00:17:34,610 --> 00:17:37,450
+السبعتاشر .. من السبعتاشر ألف في شهر اتنين هابعد
+
+187
+00:17:37,450 --> 00:17:42,590
+ألفين بسطب ده الخمستاشر، في تلت شهور لهم، ماشي،
+
+188
+00:17:42,590 --> 00:17:47,290
+كمان واحدة؟ مبيعات .. اه يا مريم، يلا مبيعات القدس
+
+189
+00:17:47,290 --> 00:17:52,390
+لشهر أربع .. سبعتاشر ألف دره .. سبعتاشر ألف دره ..
+
+190
+00:17:52,390 --> 00:17:55,590
+أربع تقصير .. ممتازة يا وانتي، أربع تقصير .. اتنين
+
+191
+00:17:55,590 --> 00:17:57,470
+.. اتنين .. اتنين .. اتنين .. اتنين .. اتنين ..
+
+192
+00:17:57,470 --> 00:17:58,110
+اتنين .. اتنين .. اتنين .. اتنين .. اتنين .. اتنين
+
+193
+00:17:58,110 --> 00:17:58,210
+.. اتنين .. اتنين .. اتنين .. اتنين .. اتنين ..
+
+194
+00:17:58,210 --> 00:18:03,050
+اتنين .. اتنين .. اتنين .. اتنين .. اتنين .. اتنين
+
+195
+00:18:03,050 --> 00:18:07,690
+.. ا
+
+196
+00:18:09,330 --> 00:18:21,150
+قداش ضايل؟ ست آلاف ناقص سبعتاشر ألف؟ ماشي كيف
+
+197
+00:18:21,150 --> 00:18:27,630
+ألف و ميان؟ ست آلاف، كيش بيكون ضايل؟ أحداشر ألف؟
+
+198
+00:18:27,630 --> 00:18:32,410
+ألف و مية مشكلة، وين أنا وين وديت بجيت لك ضاع؟ أه
+
+199
+00:18:32,410 --> 00:18:37,490
+أه، عشانك صار عندي مشكلة أنا مين يعمل شهر خمسة؟
+
+200
+00:18:37,490 --> 00:18:44,810
+أسمع17000 ضرب 5 على 2 زي 4 زي 5 زي 6 و هيطلع خمس
+
+201
+00:18:44,810 --> 00:18:49,850
+تلاف خمس تلاف نقصهم و نطلع .. اه يا سامور جدش سنة
+
+202
+00:18:49,850 --> 00:18:56,430
+بعتين .. جدش سنة بعتين .. ناشر .. جدش سنة بعتين
+
+203
+00:18:56,430 --> 00:18:59,670
+القدس؟ وين ايه يا سامور؟ خمسة و أربعة اصلا احداشر،
+
+204
+00:18:59,670 --> 00:19:01,570
+جدش ضلهم؟ ستة و أربعة اصلا احداشر، وين لازم هاد
+
+205
+00:19:01,570 --> 00:19:05,490
+كون؟ لو هالك صح .. لو يعني طبقت المعادلة هاد لازم
+
+206
+00:19:05,490 --> 00:19:10,900
+تطلع هنالما تجمعيهم يطلعوا السبعتاشر ألف، إذا
+
+207
+00:19:10,900 --> 00:19:15,400
+السبعتاشر ألف كرتونة صابونة لمنطقة القدس، بدي
+
+208
+00:19:15,400 --> 00:19:19,660
+أبعتهم للقدس على أربع فترات أو أربع مرات، إسراء
+
+209
+00:19:19,660 --> 00:19:23,860
+دبور، المرة الأولى جدش هتبعتيلهم، شهر اتنين؟
+
+210
+00:19:27,260 --> 00:19:31,380
+هت .. هنبعت .. لأ دي مصاري بصير، هنبعتله من فين
+
+211
+00:19:31,380 --> 00:19:35,360
+كرتون، في شهر أربع جداش هتبعتي أربع تلاف تكون
+
+212
+00:19:35,360 --> 00:19:40,380
+مجهزاها، في شهر خمسة أخر حاجة تضللهم عند الجداش،
+
+213
+00:19:40,380 --> 00:19:44,520
+ست تلاف، هذي بالوحدة، جداش الموازنة اللي هي
+
+214
+00:19:44,520 --> 00:19:47,640
+الإيراداتي، الفين في تمانية واربعين
+
+215
+00:19:50,180 --> 00:19:55,520
+خودي بالك دولار؟ مية و اتنين و تسعين ألف، اربع
+
+216
+00:19:55,520 --> 00:19:59,100
+ألف، ميتين و أربعين ألف، ميتين و تمانين و تمانين
+
+217
+00:19:59,100 --> 00:20:04,200
+ألف، ميتين و تمانين و تمانين ألف خودي بالك مانفعش
+
+218
+00:20:04,200 --> 00:20:07,160
+أقول هبعتلهم ستة و تسعين ألف، هذي مصاري، ماببعتش
+
+219
+00:20:07,160 --> 00:20:11,860
+أنا مصاري، لأ مابعت كمية، أنا هابعتلأ سيدة الأعمال
+
+220
+00:20:11,860 --> 00:20:16,780
+غدير اللي في القدس ألفين كرتونة صابونة هي هتبعت
+
+221
+00:20:16,780 --> 00:20:21,260
+حجهم جداش؟ 96 ألف حاجة في شهر أربع بعتلها 4000
+
+222
+00:20:21,260 --> 00:20:25,220
+جداش تبعت حجهم؟ 199 ألف واضح، كل ما بيزيد، بيزيد
+
+223
+00:20:25,220 --> 00:20:30,700
+السعر، إذا هذه حقوقي أنا اللي هي الموازنة بالدولار
+
+224
+00:20:30,700 --> 00:20:34,980
+و هذه الكميات اللي أنا لازم أجهزها و أبعتها للناس،
+
+225
+00:20:34,980 --> 00:20:38,660
+الالتزامات، برك الله فيك واضح ولا أعيدها تاني؟
+
+226
+00:20:38,660 --> 00:20:40,140
+أعيدها تاني؟
+
+227
+00:20:42,720 --> 00:20:47,800
+نشوف ال sheet في
+
+228
+00:20:47,800 --> 00:20:53,120
+حاجة .. في حد أفهم حاجة؟ عيد .. بعيد تاني مش
+
+229
+00:20:53,120 --> 00:21:00,760
+مشكلة، عيد؟ عيدها تاني؟ عيد اي اسمها؟ بقت تعب انا؟
+
+230
+00:21:00,760 --> 00:21:05,640
+ماشي ان شاء الله، الآن عندنا ال sheet سؤال رقم
+
+231
+00:21:05,640 --> 00:21:06,380
+تلاتة
+
+232
+00:21:08,810 --> 00:21:13,490
+اقرأينا يا يهودا، معاك ال sheet يا انتي؟ سؤال
+
+233
+00:21:13,490 --> 00:21:19,930
+تلاتة يا خوات شركة العودة؟
+
+234
+00:21:19,930 --> 00:21:27,430
+في
+
+235
+00:21:27,430 --> 00:21:29,790
+حد عنده مشكلة في الحساب؟ اه يا سيد الدبور، عندك
+
+236
+00:21:29,790 --> 00:21:34,330
+مشكلة؟ ماشي ان شاء الله، يلا يا هودا اقرأينا
+
+237
+00:21:34,330 --> 00:21:36,330
+السؤال بشوش، سؤال التالت
+
+238
+00:21:56,080 --> 00:21:59,360
+ممتع زي ستة و نص مش ستمية و خمسة ايوة
+
+239
+00:22:07,710 --> 00:22:14,470
+أه قداش إنتاج الشركة 6000 إذا
+
+240
+00:22:14,470 --> 00:22:17,750
+ننقص
+
+241
+00:22:17,750 --> 00:22:25,670
+بعدين يا فإن ضال حاجة لتالي ضابير الهدف
+
+242
+00:22:25,670 --> 00:22:35,290
+تتجارب من الشمال يا انتي شكرا
+
+243
+00:22:35,290 --> 00:22:38,850
+يا هودة، مين حاب يحل رقم واحد؟مين كمان؟ يالا يا
+
+244
+00:22:38,850 --> 00:22:43,850
+مريم اتفضلي كل طالبة تحاول تحل في كشكولة لحالها لو
+
+245
+00:22:43,850 --> 00:22:47,630
+سمحت كل
+
+246
+00:22:47,630 --> 00:22:52,090
+طالبة تحل لحالها السؤال الله بعينك يمسحينا
+
+247
+00:22:52,090 --> 00:23:05,690
+الصابورة مين
+
+248
+00:23:05,690 --> 00:23:14,090
+خلص حل السؤال؟عصر السرعة والله انا لسه بدي أدخل
+
+249
+00:23:14,090 --> 00:23:22,010
+شوية حبارة مين خلص سهل
+
+250
+00:23:22,010 --> 00:23:28,710
+مش صعب نعم
+
+251
+00:23:28,710 --> 00:23:32,710
+بنشوف
+
+252
+00:23:32,710 --> 00:23:35,670
+لغاية بتتغير السعر يعني
+
+253
+00:23:52,030 --> 00:23:54,790
+قداشي حكيتي عن الظقم يا وانتي؟
+
+254
+00:24:07,210 --> 00:24:12,690
+السعر هيدار زي ما هو يتغير؟ ماشي،
+
+255
+00:24:12,690 --> 00:24:25,670
+ما هو بنال عليه، بدي أشوف السعر أنا الاجمالة
+
+256
+00:24:25,670 --> 00:24:33,170
+تبع الانتاج، 6000 هو
+
+257
+00:24:33,170 --> 00:24:36,990
+بده يبيع للجدس أو للناس؟هيبعتوا لغدير لأنه غدير
+
+258
+00:24:36,990 --> 00:24:44,230
+حكت أن أنا من القدس؟ مين زي غدير من القدس؟ ما أنا
+
+259
+00:24:44,230 --> 00:24:52,850
+عارفة بس كلنا من القدس يعني مش احنا فاكنا فيها طب
+
+260
+00:24:52,850 --> 00:25:02,130
+مين منيافها؟ ما شاء الله ممتاز مين من تل الربيع؟
+
+261
+00:25:02,130 --> 00:25:05,290
+مش حلوة؟ مش معناه يعني
+
+262
+00:25:17,380 --> 00:25:28,340
+لأ احسبك .. احسبك لأ
+
+263
+00:25:28,340 --> 00:25:31,160
+احنا بنجيب الإجمالي و بعدين بنشوف العجز ..
+
+264
+00:25:31,160 --> 00:25:31,840
+الإجمالي
+
+265
+00:25:36,890 --> 00:25:41,350
+تلتلاف و خمسمية كدهش
+
+266
+00:25:41,350 --> 00:25:45,370
+المتبقى؟ ستلتلاف ناقص تلتلاف و خمسمية؟ تطلع خمسمية
+
+267
+00:25:45,370 --> 00:25:53,450
+ألفين و خمسمية ألفين و خمسمية لأ
+
+268
+00:25:53,450 --> 00:26:00,930
+ألفين و خمسمية و أنتي لا هان هان أيوة احتياجات تل
+
+269
+00:26:00,930 --> 00:26:04,690
+لظبيع احتياجات تل لظبيع
+
+270
+00:26:09,190 --> 00:26:13,090
+تل الظبيع .. تل الظبيع في السؤال
+
+271
+00:26:13,090 --> 00:26:36,270
+تلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلتلت
+
+272
+00:26:38,300 --> 00:26:42,200
+ممتازة يا عزيزي طب السعر هيتغير و لا يبقى لزمهو؟
+
+273
+00:26:42,200 --> 00:26:47,660
+تبعت للظبيع تحسبينا ياه و نستعين في صديقك، تفضلي
+
+274
+00:26:47,660 --> 00:27:00,880
+السعر؟ مين جاب السعر؟ ماشي خمسة، درع، عجز، تقسم،
+
+275
+00:27:00,880 --> 00:27:04,460
+احتاجاتها،
+
+276
+00:27:04,460 --> 00:27:05,340
+تلات تلات؟
+
+277
+00:27:08,250 --> 00:27:12,550
+خمسة في خمسمائة تلاف جيش بيعطينا خمسة .. خمسمانية
+
+278
+00:27:12,550 --> 00:27:14,970
+.. خمسمانية كده؟ تمانية .. تمانية .. تمانية ..
+
+279
+00:27:14,970 --> 00:27:17,670
+تمانية .. تمانية .. تمانية .. تمانية .. تمانية ..
+
+280
+00:27:17,670 --> 00:27:17,850
+تمانية .. تمانية .. تمانية .. تمانية .. تمانية ..
+
+281
+00:27:17,850 --> 00:27:17,850
+تمانية .. تمانية .. تمانية .. تمانية .. تمانية ..
+
+282
+00:27:17,850 --> 00:27:17,890
+تمانية .. تمانية .. تمانية .. تمانية .. تمانية ..
+
+283
+00:27:17,890 --> 00:27:18,550
+تمانية .. تمانية .. تمانية .. تمانية .. تمانية ..
+
+284
+00:27:18,550 --> 00:27:19,990
+تمانية .. تمانية .. تمانية .. تمانية .. تمانية ..
+
+285
+00:27:19,990 --> 00:27:25,510
+تمانية .. تمانية .. تمانية .. تمانية .. تمانية ..
+
+286
+00:27:25,510 --> 00:27:27,410
+تمانية .. تمانية .. تمانية .. تمانية .. تمانية ..
+
+287
+00:27:27,410 --> 00:27:36,370
+تمانية .. تمانية .. تمان
+
+288
+00:27:37,330 --> 00:27:45,210
+لازم بجد الشعب برضه يحل بنفسه سهلة أه سهلة مش صعبة
+
+289
+00:27:45,210 --> 00:27:55,370
+يالا يا غادية الموازنة المفروض
+
+290
+00:27:55,370 --> 00:27:57,510
+يا جماعة أنتوا اللي هيكوا تحلوا لإنهم شرحوا الكلام
+
+291
+00:27:57,510 --> 00:28:02,590
+هذا مش جايبين تحلوا وازماتكم يالا يا أستاذة غادية
+
+292
+00:28:02,590 --> 00:28:05,030
+موازنت
+
+293
+00:28:07,770 --> 00:28:12,470
+لأ لأ لأ لأ لسه موازنة المبيعات حسب سياسة الشركة
+
+294
+00:28:12,470 --> 00:28:34,990
+احنا الساعة في واحد ماشي
+
+295
+00:28:34,990 --> 00:28:37,410
+الكمية السعر
+
+296
+00:28:39,180 --> 00:28:43,100
+الموازنة صح صح ما هو السعر الصغنون السعر الصغنون
+
+297
+00:28:43,100 --> 00:28:48,360
+أصلا مين خلص جدول الغدير؟ أنا ممتاز يا إسراء
+
+298
+00:28:48,360 --> 00:28:52,600
+البيان
+
+299
+00:28:52,600 --> 00:28:58,720
+اللي هي القدس يافة تل الربيع الصوت لو سمحته حلو و
+
+300
+00:28:58,720 --> 00:29:04,060
+بصمت سعر ال .. لا مش سعر القدس كمية القدس كدهش؟
+
+301
+00:29:04,060 --> 00:29:13,270
+ألف و خمسمية سعرها أربعةيافا ألفين سعرها ستة و نص
+
+302
+00:29:13,270 --> 00:29:21,510
+تل الربيع قدش قول نحن ابعته ألفين و خمسمية سعرها
+
+303
+00:29:21,510 --> 00:29:25,950
+خمسة point تمانى خمسة point تمانى اعطوها النواتج
+
+304
+00:29:25,950 --> 00:29:36,370
+لو سمحتوا آية أسرع طبعا
+
+305
+00:29:36,370 --> 00:29:44,930
+الدولارشكرا يا غديا تفضلي أسماء ال band التاني
+
+306
+00:29:44,930 --> 00:29:55,910
+هنعمل ال band التاني لمنطقة تل الربيع سووا القص
+
+307
+00:29:55,910 --> 00:29:59,790
+لحالك أنتوا بتدرعوا الحاجة السهلة تسوواها صح؟
+
+308
+00:30:07,140 --> 00:30:15,660
+هنسويها لتل الربيع لأ
+
+309
+00:30:15,660 --> 00:30:20,300
+بيحددلك منطقة عشان بياخد وجهتها ده عملها حسب فصول
+
+310
+00:30:20,300 --> 00:30:30,480
+السنة لمنطقة تل الربيع مثلا وخلاص هنتبه
+
+311
+00:30:30,480 --> 00:30:36,690
+نون؟ إيش نون عندك يا ألا سيد؟عشرة، تسعة، سبعة،
+
+312
+00:30:36,690 --> 00:30:40,150
+تسعة، تسعة، تسعة، تسعة، تسعة، تسعة، تسعة، تسعة،
+
+313
+00:30:40,150 --> 00:30:42,210
+تسعة، تسعة، تسعة، تسعة، تسعة، تسعة، تسعة، تسعة،
+
+314
+00:30:42,210 --> 00:30:46,310
+تسعة، تسعة، تسعة، تسعة، تسعة، تسعة،
+
+315
+00:30:46,310 --> 00:30:47,730
+تسعة، تسعة، تسعة، تسعة، تسعة، تسعة، تسعة، تسعة،
+
+316
+00:30:47,730 --> 00:30:47,730
+تسعة، تسعة، تسعة، تسعة، تسعة، تسعة، تسعة، تسعة،
+
+317
+00:30:47,730 --> 00:30:47,750
+تسعة، تسعة، تسعة، تسعة، تسعة، تسعة، تسعة، تسعة،
+
+318
+00:30:47,750 --> 00:30:56,270
+تسعة، تسعة، تسعة، تسعة، تسعة، تسعة،
+
+319
+00:30:56,270 --> 00:31:02,870
+تسعة،
+
+320
+00:31:06,470 --> 00:31:17,470
+السعر قلنا خمسة point تمانية احنا
+
+321
+00:31:17,470 --> 00:31:22,530
+في تل الربيع يا أخوات لأن
+
+322
+00:31:22,530 --> 00:31:27,730
+احنا نبدأ نوزع لألف وخمسمية على أربع وترات مين
+
+323
+00:31:27,730 --> 00:31:33,450
+خلص؟ في ال hand مش الآن يا أسماء
+
+324
+00:31:41,950 --> 00:31:51,950
+تل الربيع؟ أيوة، هتساوي؟ ايوة،
+
+325
+00:31:51,950 --> 00:32:00,910
+ضرب؟ ممتاز، هتساوي؟ الفين و خمسمية؟
+
+326
+00:32:00,910 --> 00:32:04,570
+احنا في تل الربيع ولا شهر تلاتة؟ الفين و خمسمية؟
+
+327
+00:32:04,570 --> 00:32:06,410
+ضرب؟
+
+328
+00:32:09,280 --> 00:32:17,980
+تلاتة زيادة سبعة زيادة عشرة زيادة تسعة انا
+
+329
+00:32:17,980 --> 00:32:23,900
+حكيت الكمية الصغيرة يعني
+
+330
+00:32:23,900 --> 00:32:25,840
+مائتين و تسعة و خمسين يا نانتي هذه كميات مفهش
+
+331
+00:32:25,840 --> 00:32:32,540
+ابعتلهم ستة كيف ستة؟ بتقربوا يا أخوات إذا شهر
+
+332
+00:32:32,540 --> 00:32:37,600
+تلاتة هنبعتلهالنبعات موازمة .. نبعات موازمة ..
+
+333
+00:32:37,600 --> 00:32:42,920
+نبعات موازمة .. نبعات موازمة .. نبعات موازمة ..
+
+334
+00:32:42,920 --> 00:32:46,860
+نبعات موازمة .. نبعات موازمة .. نبعات موازمة ..
+
+335
+00:32:46,860 --> 00:32:48,120
+نبعات موازمة .. نبعات موازمة .. نبعات موازمة ..
+
+336
+00:32:48,120 --> 00:32:48,640
+نبعات موازمة .. نبعات موازمة .. نبعات موازمة ..
+
+337
+00:32:48,640 --> 00:32:50,540
+نبعات موازمة .. نبعات موازمة .. نبعات موازمة ..
+
+338
+00:32:50,540 --> 00:32:54,200
+نبعات موازمة .. نبعات موازمة .. نبعات موازمة ..
+
+339
+00:32:54,200 --> 00:33:01,640
+نبعات موازمة .. نبعات موازمة .. نبعات موازمة ..
+
+340
+00:33:01,640 --> 00:33:08,380
+نبعات موازمة .. نبعات مواز862 الحل صح و لا غلط
+
+341
+00:33:08,380 --> 00:33:13,180
+نجمعهم اجمعيهم اللي كتبتيهم توع الأرقام اللي
+
+342
+00:33:13,180 --> 00:33:17,140
+طلعتها تجمعيها للصغيرة اللي طلعت 2500 حلك صح طبعا
+
+343
+00:33:17,140 --> 00:33:20,780
+احنا عشان قربنا ممكن تطلع 2500 اشي مش مشكلة الان
+
+344
+00:33:20,780 --> 00:33:25,820
+هتبدأ تضبو في ايش؟ في السعر ايوة اضبونا لو سمحت
+
+345
+00:33:25,820 --> 00:33:30,660
+259 ضرب اه
+
+346
+00:33:30,660 --> 00:33:35,110
+دي مش مشكلة لو خلتي الرقم لأنه دي مصاريالموازنة
+
+347
+00:33:35,110 --> 00:33:40,030
+فلوس فلو ضال المقاربة عادي ألف و خمسمية و اتنين
+
+348
+00:33:40,030 --> 00:33:45,830
+ألف و خمسمية و اتنين ألف و خمسمية و اتنين ثم تلف
+
+349
+00:33:45,830 --> 00:33:48,490
+تلف و أربع تلف و سبعة و سبعة و نصفين و نصفين و
+
+350
+00:33:48,490 --> 00:33:51,550
+نصفين و نصفين و نصفين و نصفين و نصفين و نصفين و
+
+351
+00:33:51,550 --> 00:33:51,550
+نصفين و نصفين و نصفين و نصفين و نصفين و نصفين و
+
+352
+00:33:51,550 --> 00:33:51,610
+نصفين و نصفين و نصفين و نصفين و نصفين و نصفين و
+
+353
+00:33:51,610 --> 00:33:53,270
+نصفين و نصفين و نصفين و نصفين و نصفين و نصفين و
+
+354
+00:33:53,270 --> 00:33:53,270
+نصفين و نصفين و نصفين
+
+355
+00:34:10,040 --> 00:34:13,900
+تسعة و نصين تسعة و نصين تسعة و نصين تسعة و نصين
+
+356
+00:34:13,900 --> 00:34:15,560
+تسعة و نصين تسعة و نصين تسعة و نصين تسعة و نصين
+
+357
+00:34:15,560 --> 00:34:17,140
+تسعة و نصين تسعة و نصين تسعة و نصين تسعة و نصين
+
+358
+00:34:17,140 --> 00:34:17,780
+تسعة و نصين تسعة و نصين تسعة و نصين تسعة و نصين
+
+359
+00:34:17,780 --> 00:34:20,840
+تسعة و نصين تسعة و نصين تسعة و نصين تسعة و نصين
+
+360
+00:34:20,840 --> 00:34:22,880
+تسعة و نصين تسعة و نصين تسعة و نصين تسعة و نصين
+
+361
+00:34:22,880 --> 00:34:25,260
+تسعة و نصين تسعة و نصين تسعة و نصين تسعة و نصين
+
+362
+00:34:25,260 --> 00:34:37,300
+تسعة و نصين تسعة و نصين تسعة و نصين تسعة
+
+363
+00:34:37,300 --> 00:34:42,010
+و نصينهذا كان يا أخوات بالنسبة لموازنات المبيعات
+
+364
+00:34:42,010 --> 00:34:45,250
+هنبدأ
+
+365
+00:34:45,250 --> 00:34:47,750
+اليوم في الموازنة التانية في الموازنات التشغلية
+
+366
+00:34:47,750 --> 00:34:51,990
+اللي هي موازنات المخزون السلعي يلا يا أحلام
+
+367
+00:34:51,990 --> 00:34:52,510
+قرايرنا
+
+368
+00:34:58,240 --> 00:35:01,500
+بؤثر المخزون بشكل مباشر على حجم الإنتاج اللي لازم
+
+369
+00:35:01,500 --> 00:35:06,220
+يواجه المبيعات، تقونات المخزون السلعي، وحتاج تنمط
+
+370
+00:35:06,220 --> 00:35:09,900
+الصناع، وحتاج إنتاج تحت التشغيل، وحتاج مواد أولية،
+
+371
+00:35:09,900 --> 00:35:12,720
+العواصف اللي واصلة على المخزون السلعي، تكلفة
+
+372
+00:35:12,720 --> 00:35:15,040
+التنمط الصناعي، شوي شوي شوي شوي، إذا اننا أخوات
+
+373
+00:35:15,040 --> 00:35:17,700
+المخزون السلعي، خودي بالك المخزون عندنا أنواع،
+
+374
+00:35:17,700 --> 00:35:21,480
+عندنا هذا المخزون السلعي، اللي هو يعني مخزون سلعة
+
+375
+00:35:21,480 --> 00:35:28,100
+تنمط الصناعي، بيؤثر على حجم الإنتاج، كيف؟الان انا
+
+376
+00:35:28,100 --> 00:35:32,840
+طلبوا مني ليافة ألفين كرتونة يا أحلام، بروحش أعمل
+
+377
+00:35:32,840 --> 00:35:37,520
+ألفين كرتونة على طول أنتجها، لأ بروح المخزن، ضايل
+
+378
+00:35:37,520 --> 00:35:41,140
+بنطرح اللي ضايل و بنكمل الباقي، مش ضايل بنعمل
+
+379
+00:35:41,140 --> 00:35:46,220
+الألفين، إذا أنا طلبوا مني ليافة ألفين كرتونة،
+
+380
+00:35:46,220 --> 00:35:50,500
+بروحش عن الألفين، بروح المخزن، بفتحه، لجيت فيه 200
+
+381
+00:35:50,500 --> 00:35:55,690
+كرتونةقداش بساوي ضايل؟ الف وتمنمية الف وتمنمية زاد
+
+382
+00:35:55,690 --> 00:35:59,570
+المتل اللي جيناهم في النقزان هي الفلايافة واضح؟ ما
+
+383
+00:35:59,570 --> 00:36:02,030
+هي مقونات المخزون السلاحي؟ طبعا حسب المصنع إما
+
+384
+00:36:02,030 --> 00:36:06,710
+تامة الصنع أو تحت التشغيل لسه بدنا نشغل عليها أو
+
+385
+00:36:06,710 --> 00:36:11,570
+مواد خام ممكن يكون مخزون مواد خام أبسط عشان
+
+386
+00:36:11,570 --> 00:36:13,690
+العوامل المواطرة عن المخزون السلاحي بتاخدوها في
+
+387
+00:36:13,690 --> 00:36:17,690
+المخازن هذه تفضلي أحلى تكلفة التخزين وتكلفة الشراء
+
+388
+00:36:17,690 --> 00:36:20,810
+وندرة المواد وتوفير رأس المال العامل وسياسة الـ
+
+389
+00:36:21,140 --> 00:36:25,180
+وسياسة الإدارة ممتاز في حاجة أخدتوها برضه في
+
+390
+00:36:25,180 --> 00:36:28,660
+المخازن و أخدتوها في الإدارة المالية اللي هي
+
+391
+00:36:28,660 --> 00:36:33,820
+الكمية الاقتصادية للجدر تربيعي هداك للمخزون تفضلي
+
+392
+00:36:33,820 --> 00:36:38,040
+أحلى الحجم العكسي للمخزون هو ذلك الحجم اللي ..
+
+393
+00:36:38,040 --> 00:36:41,500
+اللي بتحفظ عنده التكاليف الإجمالي للمخزون الأدنى
+
+394
+00:36:41,500 --> 00:36:44,640
+حد ممكن الحجم اللي بنحققه عنده أقل تكاليف ممكنة
+
+395
+00:36:44,640 --> 00:36:47,740
+بنسميه الحجم الأمتل للمخزون مش موضوعنا في المساقى
+
+396
+00:36:47,740 --> 00:36:51,920
+هذا شكرا يا أحلىأه يا سمون ادخل يا نوع تكاليف
+
+397
+00:36:51,920 --> 00:36:57,660
+المخزون ببساطة
+
+398
+00:36:57,660 --> 00:37:00,460
+يا أخوتي يعني بدل ما ندفع مصارف المخازن كممكن ندفع
+
+399
+00:37:00,460 --> 00:37:04,840
+المصارف أيش تاني؟ ليه الفرصة الفديلة؟ اتنين؟ اللي
+
+400
+00:37:04,840 --> 00:37:07,800
+هي التبريد ده؟ جبت حرارة انحارس المي الكهرة
+
+401
+00:37:07,800 --> 00:37:14,490
+بالتليفون تبعت المخازن؟أنا عندي 200 كرتونة لما
+
+402
+00:37:14,490 --> 00:37:17,950
+جينا انطلهم لجينا في منهم الميه داخل عليه مخرباه
+
+403
+00:37:17,950 --> 00:37:23,370
+لو طحين الفارق داخل عليه و هكذا شكرا يا آية، مسوس
+
+404
+00:37:23,370 --> 00:37:26,450
+مثلا هنادر شاصي ما هي هداف سياسة المخزون السلعي
+
+405
+00:37:26,450 --> 00:37:29,670
+الحجم الاقتصادي الأكثر من المخزون اللي دي سيادات
+
+406
+00:37:29,670 --> 00:37:32,090
+تبع عليه تحديد مواعي الإنتاج والكمية
+
+407
+00:37:37,790 --> 00:37:40,950
+إذا الحجم الاقتصادي طبعا حكيناها للمخزون بترتب
+
+408
+00:37:40,950 --> 00:37:45,510
+عليه تحديد مواعيد الإنتاج وإيش وكمياته بمعنى طول
+
+409
+00:37:45,510 --> 00:37:50,010
+ما المخازن فيها إبضاع بشغلش أنا مابضلش هاندج جربت
+
+410
+00:37:50,010 --> 00:37:52,990
+لخلص أشمالنا إبن انتج يعني مابضلش أكدس إبضاع في
+
+411
+00:37:52,990 --> 00:37:57,250
+المخازن المشكلة هذه مخزون تكلفة أيوة شكرا يا هنادي
+
+412
+00:37:57,250 --> 00:38:00,970
+الساعة شغل مرمية نوع التكلفة اللي تحتاج ليها هدا
+
+413
+00:38:00,970 --> 00:38:02,030
+تحديد الحكم اقتصاد المخزون
+
+414
+00:38:07,470 --> 00:38:13,890
+لأ يا رجل احنا خلصناه انت ترجع ترجع
+
+415
+00:38:20,770 --> 00:38:24,130
+أه يا سامونو هنادي خليكم معانا تكلفة فرص المدينة
+
+416
+00:38:24,130 --> 00:38:40,090
+شرحناها تكلفة المتافع للشراء شكرا
+
+417
+00:38:40,090 --> 00:38:45,090
+يا عزيزي فيه ما يوحدة مش واضحة أشرحها أي دلال فيه
+
+418
+00:38:45,090 --> 00:38:50,940
+ما يتكلف أشرحها فيه ما يتكلف أشرحهاهناخد اليوم
+
+419
+00:38:50,940 --> 00:38:53,180
+القانون ونحل السؤال المحاضرة القادمة إن شاء الله
+
+420
+00:38:53,180 --> 00:38:57,080
+لأنه بندوقة جدا سماعة أبو دقة ما هو موضوع أو وضحي
+
+421
+00:38:57,080 --> 00:39:02,480
+بالرسم معلش سماعة أبو جامع موقع موازنة مخزون السلع
+
+422
+00:39:02,480 --> 00:39:07,560
+من الموازنات أول حاجة لازم يكون عندك موازنة
+
+423
+00:39:07,560 --> 00:39:13,000
+المبيعات خدي بالك احنا بنخزن وحدات مش دولارات
+
+424
+00:39:13,000 --> 00:39:16,440
+فلازم تكون المبيعات بالوحدات لو حلتيها الدولار
+
+425
+00:39:16,440 --> 00:39:21,630
+السؤال كله غلطانعيد مرة تانية يا أحلام موازنة
+
+426
+00:39:21,630 --> 00:39:25,630
+المبيعات هان حكينا المحاضرة الماضية نوعين إما
+
+427
+00:39:25,630 --> 00:39:29,470
+دولار أو وحدة لو أنا بدأ أجيب موازنة المخزون لازم
+
+428
+00:39:29,470 --> 00:39:33,710
+أكون عند المبيعات بالوحدة مانفعش أنحلها الدولارات
+
+429
+00:39:33,710 --> 00:39:36,390
+معناه إحنا مانخزن دولارات إحنا مانخزنش دولارات
+
+430
+00:39:36,390 --> 00:39:39,990
+إحنا مانخزن أمضاعة قاعدين فاخد بالك لو حلت السؤال
+
+431
+00:39:39,990 --> 00:39:43,750
+عن موازنة المبيعات بالوحدة كله غلط معناه الحمد لله
+
+432
+00:39:43,750 --> 00:39:48,910
+مش هالمحاجة فأيوة يا سماحبناءً عن المبيعات بقدر
+
+433
+00:39:48,910 --> 00:39:53,470
+أعمل مقصود أصطلاعي و بعد ذلك الأش الانتاج شكرا
+
+434
+00:39:53,470 --> 00:39:58,650
+أنتي هنقرأ السؤال و نحن المحاضرة الجاية يتفضلي يا
+
+435
+00:39:58,650 --> 00:40:03,070
+نون عمارة موزمة مقصود أصطلاعي أقول المثال ولا بس
+
+436
+00:40:03,070 --> 00:40:08,670
+القانون؟ هنقرأ اقرأ المثال هنقرأ السؤال مثل شركة
+
+437
+00:40:08,670 --> 00:40:12,730
+فجر سياستها في المقصود أصطلاعي لاتقل عن 25% خط خط
+
+438
+00:40:15,640 --> 00:40:18,760
+أيوة؟ مبيعات الشهر التالي المطلوب إعداد موازنة
+
+439
+00:40:18,760 --> 00:40:22,860
+المخزون السلعي لتلات شهور إذا في حاجة ناقصة في
+
+440
+00:40:22,860 --> 00:40:28,660
+السؤال لتلات شهور كملوا معايا لو سمحتوا السؤال
+
+441
+00:40:28,660 --> 00:40:35,780
+ناقصان وكانت المبيعات كالقاتى
+
+442
+00:40:35,780 --> 00:40:43,100
+وكانت المبيعات كالقاتى هتروح رسمة جدول من تلات
+
+443
+00:40:43,100 --> 00:40:43,520
+أعمدة
+
+444
+00:40:47,230 --> 00:40:52,370
+كاتبة فيه noon العمود الأول الكمية اللي هي كمية
+
+445
+00:40:52,370 --> 00:40:56,930
+النبع طبعا العمود التاني والسعر العمود التالت
+
+446
+00:40:56,930 --> 00:41:03,090
+السعر ثابت عشرين عشرين عشرين السعر عشرين عشرين
+
+447
+00:41:03,090 --> 00:41:08,830
+عشرين عشرين أربع مرات لعشرين noon اللي هي الأشهر
+
+448
+00:41:08,830 --> 00:41:13,650
+واحد اتنين تلات أربع noon واحد اتنين تلات أربع
+
+449
+00:41:13,650 --> 00:41:21,970
+الكمية كانت الشهر الأول الفينالشهر التاني ست آلاف،
+
+450
+00:41:21,970 --> 00:41:27,790
+الشهر التالت خمس آلاف، الشهر الرابع أربع آلاف،
+
+451
+00:41:27,790 --> 00:41:33,490
+هأجي السؤال، أعد موازنة المخزون لتلات إيش؟ أشهر،
+
+452
+00:41:33,490 --> 00:41:38,710
+هنحن من المحاضرة القادمة، أخر حاجة، إيش القانون
+
+453
+00:41:38,710 --> 00:41:39,650
+اللي بنمشي عليه؟
+
+454
+00:41:43,080 --> 00:41:47,640
+مبيعاتنا في نسبة لمخزون، من حلل المحاضرات القادمة،
+
+455
+00:41:47,640 --> 00:41:52,900
+في أي سؤال أو سفسار؟ أي سؤال؟ أي سؤال؟ يعطيكوا
+
+456
+00:41:52,900 --> 00:41:53,260
+العافية
+
diff --git a/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/yll96li062o_postprocess.srt b/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/yll96li062o_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..2250c46c7d8e35fa9dd4559da82585c29e176aa6
--- /dev/null
+++ b/PL9fwy3NUQKwamLrfZ4Ozpk8OB7lnBYxvR/yll96li062o_postprocess.srt
@@ -0,0 +1,1784 @@
+1
+00:00:00,000 --> 00:00:01,100
+موسيقى
+
+2
+00:00:21,210 --> 00:00:23,730
+عوضوا بالله السميع العليم من الشيطان الضجيم بسم
+
+3
+00:00:23,730 --> 00:00:26,730
+الله الرحمن الرحيم الحمد لله والصلاة والسلام على
+
+4
+00:00:26,730 --> 00:00:30,930
+المصطفى الأمين سيدنا محمد وعلى أهله ومن سارة عداده
+
+5
+00:00:30,930 --> 00:00:33,610
+الحسين ومن الدين في البداية السلام عليكم ورحمة
+
+6
+00:00:33,610 --> 00:00:39,450
+الله كيف حالكم؟ كيف أصبحتوا اليوم؟ كويسي إن شاء
+
+7
+00:00:39,450 --> 00:00:43,310
+الله؟ دوم إن شاء الله اليوم هناخد أخر حاجة في
+
+8
+00:00:43,310 --> 00:00:46,110
+course behavior إن شاء الله نشوف مع بعض إيش أخدنا؟
+
+9
+00:00:46,110 --> 00:00:51,060
+إيش تعلمنا؟اتعرفنا على عوامل بتساعدنا في عملية
+
+10
+00:00:51,060 --> 00:00:55,820
+حساب، نضع محاسبة التكليف، تعرفنا على شو يعني
+
+11
+00:00:55,820 --> 00:01:01,500
+تكلفة؟ مين يذكرنا إيش؟ هتعرفي ال cost؟ هودا؟ هى؟
+
+12
+00:01:01,500 --> 00:01:05,200
+هى تضحية بالموارد .. ممتاز يا هودا، بارك الله فيك،
+
+13
+00:01:05,200 --> 00:01:09,940
+اتعرفنا على عوامل مارترة في نضع محاسبة التكليف؟
+
+14
+00:01:12,050 --> 00:01:15,990
+شوفنا مع بعض كيف انفرج بين هل الرقم اللي أمامي
+
+15
+00:01:15,990 --> 00:01:21,570
+تكلفة للوحدة ولا إجمالي تكاليف بعد هيك أخدنا طريقة
+
+16
+00:01:21,570 --> 00:01:25,270
+حسابية و أخدنا أمتلة أو أخدنا sheet فردنا بين
+
+17
+00:01:25,270 --> 00:01:30,990
+التكلفة و المصروف و الخسارة و أخدنا عليهم أمتلة
+
+18
+00:01:30,990 --> 00:01:35,910
+شوفنا
+
+19
+00:01:35,910 --> 00:01:41,010
+التكاليف في إيش بتفيدني تعرفنا عن التكاليف، القطاع
+
+20
+00:01:41,010 --> 00:01:41,530
+الخدمي
+
+21
+00:01:45,990 --> 00:01:49,690
+شوفنا كيف ممكن نحسب الأسعار؟ خدنا مع بعض أصناف
+
+22
+00:01:49,690 --> 00:01:55,650
+التكاليف خدنا مع بعض التكاليف حسب النوع، التكاليف
+
+23
+00:01:55,650 --> 00:02:02,350
+حسب الوظيفة، التكاليف حسب التخطيط، التكاليف حسب
+
+24
+00:02:02,350 --> 00:02:04,530
+التخطيط اللي هناخدها اليوم، التكاليف حسب السلوك
+
+25
+00:02:04,530 --> 00:02:08,970
+والتكاليف حسب وظائف المشروع اللي إشرحناها، هنكمل
+
+26
+00:02:08,970 --> 00:02:14,290
+اليوم مع بعض في التكاليف حسب التخطيط
+
+27
+00:02:16,230 --> 00:02:28,290
+شوف مع بعض هذا
+
+28
+00:02:28,290 --> 00:02:32,150
+كل ما ضين عليها شرحناها أخدنا عليها أنتلا طبعا
+
+29
+00:02:32,150 --> 00:02:33,110
+أنتلا كلها واقعية
+
+30
+00:02:59,750 --> 00:03:04,790
+نشوف التكاليف لغاية التخطيط أول حاجة عندنا
+
+31
+00:03:04,790 --> 00:03:12,750
+التكاليف التفاضلية التكاليف الاش؟ التفاضلية تفضلي
+
+32
+00:03:12,750 --> 00:03:16,650
+آيالي عوضك لينا لو سمحتي التكاليف التفاضلية وهي
+
+33
+00:03:16,650 --> 00:03:19,950
+الفرق بين تكاليف البدائل المختلفة لاختيار البديل
+
+34
+00:03:19,950 --> 00:03:22,550
+الأفضل وانتخاب القرار المناسب من أجل التخطيط
+
+35
+00:03:22,550 --> 00:03:30,620
+المستقبلي التكاليف التفاضلية روحتي تشتري حاجةأمالك
+
+36
+00:03:30,620 --> 00:03:37,040
+جلبابع حكالك واحد من 200 شكل والتاني من 300 شكل
+
+37
+00:03:37,040 --> 00:03:42,740
+تكون قيمة تفاضلي أيهما بناسبك لأن تكاليف التفاضلي
+
+38
+00:03:42,740 --> 00:03:48,260
+أيهما أفضل أيهما إيش؟ أفضل بالنسبة للتكلفة طبعا
+
+39
+00:03:48,260 --> 00:03:52,880
+دائما يا أخوان بالنسبة للتكلفة مع تثبيت عنصر
+
+40
+00:03:52,880 --> 00:03:58,430
+الجودة الأقل أفضللكن مايكونش احسبش .. ايش يعني انت
+
+41
+00:03:58,430 --> 00:04:02,530
+بتبتعنصر الجودة؟ مايكونش احسب الجودة اذا انا عندي
+
+42
+00:04:02,530 --> 00:04:07,530
+اتنين جلباب نفس الخامة ماشي لكن الموديلات اختلفت
+
+43
+00:04:07,530 --> 00:04:13,410
+فالسعر اختلف بداله نفس الجودة و الموديلين عاجبيني
+
+44
+00:04:13,410 --> 00:04:17,250
+بصير الفيصل اللي هو السعر اذا ايهم افضل في
+
+45
+00:04:17,250 --> 00:04:21,150
+التكاليف؟ التكاليف الاقل الاقل .. الاش .. الاقل
+
+46
+00:04:25,540 --> 00:04:33,920
+شكرا يا آية اسمها ماشي
+
+47
+00:04:33,920 --> 00:04:38,340
+ان شاء الله ألف سلام عليك يا نور تحكي تانيا تكاليف
+
+48
+00:04:38,340 --> 00:04:42,700
+التفاضل أه اتفضلي إذا تسوى التكاليف من تحت بديلين
+
+49
+00:04:42,700 --> 00:04:46,920
+فإن تكاليفه لا تؤثر على القرار متى تكون التكاليف
+
+50
+00:04:46,920 --> 00:04:57,150
+غير تفاضلية؟ متى تكون التكاليفغير تفاضلية إيه ده
+
+51
+00:04:57,150 --> 00:05:05,090
+تساوت؟ إيه ده إيش؟ إيه ده تساوت؟ بمعنى الجلم هذا
+
+52
+00:05:05,090 --> 00:05:10,010
+جدش حجه جالي عشرة شكل و هذا عشرة شكل بفكرش في
+
+53
+00:05:10,010 --> 00:05:14,110
+السعر بفكر في اللون ليش في اللون؟ لإن اللون اللي
+
+54
+00:05:14,110 --> 00:05:20,410
+اختلف لكن لما السعر نفسه بفكرش فيه جدش يجي باب هذا
+
+55
+00:05:20,410 --> 00:05:25,580
+تلاتمين شكل و هذا تلاتمين شكل بفكرش في السعرإذا
+
+56
+00:05:25,580 --> 00:05:31,040
+تساوة التكاليف تصبح غير تفاضلية، تصبح أش غير
+
+57
+00:05:31,040 --> 00:05:33,680
+تفاضلية، إيش معناه غير تفاضلية؟ يعني بفضلش تكلفه
+
+58
+00:05:33,680 --> 00:05:39,380
+على أخرى، خلاص، مش زي بعض، تفضليه؟ لأنه عند اتخاذ
+
+59
+00:05:39,380 --> 00:05:42,880
+قرار باختيار أي بديل، فإن المنش أسافر تتحمل نفس
+
+60
+00:05:42,880 --> 00:05:46,960
+التكاليف أو أنها ستحقق نفس الإرادة ليش؟ لأنه هي
+
+61
+00:05:46,960 --> 00:05:50,080
+سواء اختارتي ألف و لا بقى، سواء شرتي جيام الأسود و
+
+62
+00:05:50,080 --> 00:05:53,580
+لا الأسد، لأن أنا هادفع نفس أش، نفس السعر، فبفكرش
+
+63
+00:05:53,580 --> 00:05:57,130
+في أش في السعروالدالي جيتى مستبعد هذه التكاليف
+
+64
+00:05:57,130 --> 00:06:00,330
+والإرادة مستبعد بفكرش فيها يعني مستبعد اللي هو إيش
+
+65
+00:06:00,330 --> 00:06:06,110
+بفكرش فيها عندنا مثال صفحة تلاتة و تلاتين مثال رقم
+
+66
+00:06:06,110 --> 00:06:12,130
+اتنين حد معاك كتاب؟ مثال صفحة تلاتة و تلاتين
+
+67
+00:06:12,130 --> 00:06:16,190
+ماعكوش
+
+68
+00:06:16,190 --> 00:06:20,490
+الكتاب؟ الحمد لله نكتب موقعيات السؤال
+
+69
+00:06:28,310 --> 00:06:38,650
+إذا أعطيتي البيانات التالية التي
+
+70
+00:06:38,650 --> 00:06:42,030
+أتيحت
+
+71
+00:06:42,030 --> 00:06:53,550
+أمامك أو أمامك كمحاسبة إدارية وطلب منك المدير
+
+72
+00:06:53,550 --> 00:06:54,170
+المالي
+
+73
+00:06:58,150 --> 00:07:07,850
+اختيار أي البدائي الأفضل هاي
+
+74
+00:07:07,850 --> 00:07:12,210
+المعطيلة السؤال، المعطيلة جدول مكومة تلت أعمدة،
+
+75
+00:07:12,210 --> 00:07:16,310
+بتكتب السؤال هناك عشان أحلها
+
+76
+00:07:41,460 --> 00:07:46,640
+هي عندنا البيان اللي هنكتب فيه المسميات بعدين
+
+77
+00:07:46,640 --> 00:08:01,920
+البديل الأول التسويق القديم البديل التاني التسويق
+
+78
+00:08:01,920 --> 00:08:07,440
+الحديث أو بين قصير المقترح يعني البديل التاني هو
+
+79
+00:08:07,440 --> 00:08:16,350
+إيش؟ المقترحإيش المعطيات؟ تكلفة المبيعات في القديم
+
+80
+00:08:16,350 --> 00:08:22,010
+ستين ألف لش جيه التمانين طبعا من دلوقت أي أخرات
+
+81
+00:08:22,010 --> 00:08:28,970
+ميم مصاريف .. ميم إيش معناها؟ مصاريف .. مصاريف
+
+82
+00:08:28,970 --> 00:08:35,830
+الإعلان القديمة كانت عشرين ألف لش جيه ده عشرة ألف
+
+83
+00:08:35,830 --> 00:08:43,570
+ميم عمومياللي هي المصاريف العمومية القديمة 15،
+
+84
+00:08:43,570 --> 00:08:49,190
+الجديدة 20 ميم أخرى، أي مصاريف أخرى، زي النتريات
+
+85
+00:08:49,190 --> 00:08:57,610
+مثلا 35 القديمة، 35 الجديدة، ماشي، بعدين الإيراد
+
+86
+00:08:57,610 --> 00:09:06,650
+الإيراد زمان 150، لو عملنا تسويق جديد هيصير 200،
+
+87
+00:09:06,650 --> 00:09:15,600
+طبعا بالألفالسؤال ساعدي المدير المالي على اتخاذ
+
+88
+00:09:15,600 --> 00:09:22,060
+القرار ايش القرار يا خوات؟ زي ما انتوا عارفين
+
+89
+00:09:22,060 --> 00:09:32,460
+اختيار بديل واحد فقط هل نبقى على التسويق القديم ام
+
+90
+00:09:32,460 --> 00:09:37,340
+نتجه للتسويق
+
+91
+00:09:39,060 --> 00:09:43,660
+يسمينا الحديث هاي القرار إن أنا أخد واحد بس مينفعش
+
+92
+00:09:43,660 --> 00:09:47,380
+أقوله أعمل اتنين مينفعش أحكيله سوى الأتنين، مصبوطش
+
+93
+00:09:47,380 --> 00:09:53,180
+إذا في عندنا مؤسسة، في حاجة يا عمتي؟ طولي بالك يا
+
+94
+00:09:53,180 --> 00:09:58,980
+عمتي، شوي شوي عندنا مؤسسة عندها تسويق وكل شيء تمام
+
+95
+00:09:58,980 --> 00:10:02,960
+إجوا ناس اقترحوا عليها تسويق جديد ممكن يكون
+
+96
+00:10:02,960 --> 00:10:08,260
+إلكتروني السؤال هل انضل على التسويق القديم؟
+
+97
+00:10:10,640 --> 00:10:15,280
+هل يروح التصييق الجديد و نسمع كلامه؟ نصحتهم؟ بنفعش
+
+98
+00:10:15,280 --> 00:10:19,840
+و أنا قاعدة هيك أحكي أو أتخذ القرار، لازم أعمل
+
+99
+00:10:19,840 --> 00:10:27,120
+دراسة بناء عليها أتخذ إيش؟ القرار تعالوا
+
+100
+00:10:27,120 --> 00:10:30,500
+نطلع على البيانات، خلصتوا يا خاطوة ولا استنا شوية؟
+
+101
+00:10:30,500 --> 00:10:41,440
+لسه توحكين إذا الرقم اتغير، يأخذ بعين الاعتبارو
+
+102
+00:10:41,440 --> 00:10:48,560
+إذا ضال تابت يهمل .. يستبعد كل
+
+103
+00:10:48,560 --> 00:10:52,980
+طالبة تتطلع على الأرقام اللي كتبتها و تطلع ال band
+
+104
+00:10:52,980 --> 00:10:58,720
+اللي هيستبعد في عندك band هيستبعد؟ ممتاز ليش كفاية
+
+105
+00:10:58,720 --> 00:11:05,840
+مصاريف أخرى؟ نطلع يا أخوان خلصت كتابة و لسه؟ في حد
+
+106
+00:11:05,840 --> 00:11:08,060
+لسه بكتب؟ نمسكهم واحد واحد
+
+107
+00:11:10,830 --> 00:11:13,570
+تكلفة المبيعات كانت ستين صارت تمانين اتغيرت ولا زي
+
+108
+00:11:13,570 --> 00:11:17,950
+ما هي؟ اتغيرت مصاريف اهلان كانت اتشين صارت عشرة
+
+109
+00:11:17,950 --> 00:11:21,850
+اتغيرت انخفاض او زيادة مش مشكلة مهم ان الكون
+
+110
+00:11:21,850 --> 00:11:24,990
+اتغيرت مصاريف عمره مية كانت خمستاشر صارت عشرين
+
+111
+00:11:24,990 --> 00:11:31,950
+اتغيرت مصاريف اخر كانت خمس وثانين بلقى بخمس وثانين
+
+112
+00:11:31,950 --> 00:11:38,810
+ابن اكتي بجنبها هذه ماعرف انها التابعة لأ
+
+113
+00:11:40,820 --> 00:11:48,220
+لم تتغير التابعة إش تاني هذه مصاريف لم تتغير إذا
+
+114
+00:11:48,220 --> 00:11:52,000
+هي غير تفاضلية ما تكتبيش تابعة .. تابعة إش تاني
+
+115
+00:11:52,000 --> 00:11:59,980
+هذه التكاليف لم تتغير إذا هي غير تفاضلية نفتح
+
+116
+00:11:59,980 --> 00:12:06,860
+course غير ملائمة في اتخاذ القرار إش معنى غير
+
+117
+00:12:06,860 --> 00:12:13,430
+ملائمة؟ لا تساعدنيبساعدنيش في اتخاذ القرار؟ إيش
+
+118
+00:12:13,430 --> 00:12:16,290
+يعني بساعدنيش في اتخاذ القرار؟ بمعنى يا أخوات،
+
+119
+00:12:16,290 --> 00:12:19,670
+ضليتي على التسويق القديم أو روحتي على الحديث، مش
+
+120
+00:12:19,670 --> 00:12:27,770
+هتتغير، فبروح طيلاها مطلعة، ماشي؟ الإيراد،
+
+121
+00:12:27,770 --> 00:12:32,030
+التفاضل اللي مش تفاضل، تفاضل تعالوا يا أخوات نحل
+
+122
+00:12:32,030 --> 00:12:37,350
+السؤال، خلوني أحل و أنا، ماشي، عشان هجينا جدا هذا
+
+123
+00:12:37,350 --> 00:12:42,370
+الكلامفتكون معلومة تابتة من أولها إن شاء الله الحل
+
+124
+00:12:42,370 --> 00:12:48,430
+هروح يا أخوات .. عفوا بصم نفس الجدول شايفين
+
+125
+00:12:48,430 --> 00:12:51,550
+بالأحمر ولا أغير اللون؟ أنا بس بدي أصم الجدول
+
+126
+00:12:51,550 --> 00:12:59,770
+واحد، اتنين، تلاتة إذا
+
+127
+00:12:59,770 --> 00:13:04,130
+أنا عملت نفس الجدول اللهم أضفة عمود جديد العمود
+
+128
+00:13:04,130 --> 00:13:05,590
+الجديد هنسميه دفاضل
+
+129
+00:13:11,860 --> 00:13:15,900
+وهنا البيان البيان
+
+130
+00:13:15,900 --> 00:13:20,280
+ماشي الان
+
+131
+00:13:20,280 --> 00:13:24,680
+بضلع ان اخد بالي فى ناس بيقولوا البديل الأول بعدين
+
+132
+00:13:24,680 --> 00:13:27,340
+البديل التانى وفى ناس بيقولوا البديل التانى بعدين
+
+133
+00:13:27,340 --> 00:13:30,720
+البديل الأول ماشي أهم إشي أن أكون فاهم الأرقام
+
+134
+00:13:30,720 --> 00:13:34,180
+عشان أعرف أحل الصح و أمنتظر تاخد القراش الصحيح
+
+135
+00:13:34,180 --> 00:13:40,380
+هنقول هنا التسويق القديم التسويق القديم يا أخوات
+
+136
+00:13:40,380 --> 00:13:47,170
+اللي هو الوضع الحاليو بعدين التسويق المقترح اللي
+
+137
+00:13:47,170 --> 00:13:58,470
+هو الحديث ماشي أكمل ولا أستنى؟ ها دي قائمة الدخل
+
+138
+00:13:58,470 --> 00:14:03,330
+أول حاجة في قائمة الدخل بيكون الإيراد ناقص أول شي
+
+139
+00:14:03,330 --> 00:14:06,750
+في قائمة الدخل مين بيكون؟ الإيراد اللي هو الكمية
+
+140
+00:14:06,750 --> 00:14:14,370
+في السعة قداش إيراداتك في السؤال؟ اليوم 150حصل
+
+141
+00:14:14,370 --> 00:14:19,010
+ايش؟ ميتين اطلح لو سمحت مية و خمسين ناقص ميتين
+
+142
+00:14:19,010 --> 00:14:31,350
+موجب ولا سالب؟ موجب موجب موجب موجب موجب موجب موجب
+
+143
+00:14:31,350 --> 00:14:33,350
+موجب موجب موجب موجب موجب موجب موجب موجب موجب موجب
+
+144
+00:14:33,350 --> 00:14:33,510
+موجب موجب موجب موجب موجب موجب موجب موجب موجب موجب
+
+145
+00:14:33,510 --> 00:14:34,210
+موجب موجب موجب موجب موجب موجب موجب موجب موجب موجب
+
+146
+00:14:34,210 --> 00:14:39,770
+موجب موجب موجب موجب موجهي مش سالف .. مش سالف .. مش
+
+147
+00:14:39,770 --> 00:14:43,830
+عشانها إيراد .. بس سالف عشان نعمليه ال .. طرح أيوة
+
+148
+00:14:43,830 --> 00:14:48,210
+لأن التكاليف عندنا
+
+149
+00:14:48,210 --> 00:14:56,530
+تكاليف المبيعات عندنا مصاريف الإعلان مصاريف عمومي
+
+150
+00:14:56,530 --> 00:15:05,730
+مصاريف أخرى لو اتطلعتي هتلاقي نفسك مش ضال ولا بيان
+
+151
+00:15:05,730 --> 00:15:11,790
+في الجدول اللي كتبتيهحققش هان اكتب مجموع المصاريف
+
+152
+00:15:11,790 --> 00:15:16,190
+تاكد
+
+153
+00:15:16,190 --> 00:15:25,610
+من بعد كده كانت؟ ستين ألف كده حصية؟ بسالب خدي بالك
+
+154
+00:15:25,610 --> 00:15:30,390
+أنا ميزت بين السوالب تكاليف دايما سالب مصاريف
+
+155
+00:15:30,390 --> 00:15:38,070
+الإعلان كانت عشرين؟ حصية؟عشرة، انها تنجس، هذه
+
+156
+00:15:38,070 --> 00:15:44,410
+ممتازة، هذه حلوة ليش هذه حلوة؟ لأنه لو ضلينا زي ما
+
+157
+00:15:44,410 --> 00:15:47,430
+احنا كنا ندفع عشرين، لو صلنا أشداد، عشرة، خلّت،
+
+158
+00:15:47,430 --> 00:15:56,610
+التقليب لمّا دخل ممتاز مصاريف عمومي؟ وحشة،
+
+159
+00:15:56,610 --> 00:16:01,090
+ليش وحشة؟ مش عشان بالسلب، عشانها زادت مصاريف أخرى
+
+160
+00:16:08,050 --> 00:16:18,330
+كتبنا جنب أي شغيرة تفضلية طلعونا الإجمالي ايوة
+
+161
+00:16:18,330 --> 00:16:26,410
+بسالبة
+
+162
+00:16:26,410 --> 00:16:31,650
+ده
+
+163
+00:16:31,650 --> 00:16:39,020
+جيبت بهان الصحف النبياطلح لو سمحت الأخضر من بعضه
+
+164
+00:16:39,020 --> 00:16:43,360
+اطلح
+
+165
+00:16:43,360 --> 00:16:46,400
+الأخضر من بعضه موجب موجب سالب سالب تسبب لهم تاني
+
+166
+00:16:46,400 --> 00:16:51,240
+مية و خمسين نقص مية و تلاتين موجب ولا سالب
+
+167
+00:16:55,760 --> 00:16:57,740
+يعني احنا اليوم ربحانين اصلا، يعني لو وضعنا ..
+
+168
+00:16:57,740 --> 00:16:59,940
+وضعنا زي ما احنا، لا تسييق حديث ولا حاجة، احنا
+
+169
+00:16:59,940 --> 00:17:03,200
+ربحانين كيف يبقى الصوفي الانتجة؟ ها يا انت، امشي
+
+170
+00:17:03,200 --> 00:17:05,700
+مع الخط الأحمر، الإيراد .. خدوا من بعض، الإيراد
+
+171
+00:17:05,700 --> 00:17:12,160
+ناقص مجموع المصاريف 150 ناقص 130، هذه قائمة الدخل
+
+172
+00:17:12,160 --> 00:17:17,500
+ليش يبقى الصوفي الانتجة؟ الإيراد غير التكليف، هذا
+
+173
+00:17:17,500 --> 00:17:20,680
+كلام أخدته في المالية، الإدار الماليهذه قائمة
+
+174
+00:17:20,680 --> 00:17:24,140
+الدخل نطلع صفر الربح أو صفر الخسارة الإيراد ناقص
+
+175
+00:17:24,140 --> 00:17:27,780
+التكاليف نخده من بعض الإيراد ناقص جمال يعيش
+
+176
+00:17:27,780 --> 00:17:34,980
+المصاريف هذه القاعدة عامة خدته في المالية 200 ناقص
+
+177
+00:17:34,980 --> 00:17:42,360
+145 موجب
+
+178
+00:17:42,360 --> 00:17:48,960
+ولا سالم؟ موجبالان عشرين نقص خمسة و خمسين التفاضل
+
+179
+00:17:48,960 --> 00:17:52,280
+دايما تروح يا أخواتي التفاضل دايما تروح عشرين نقص
+
+180
+00:17:52,280 --> 00:17:52,940
+خمسة و خمسين
+
+181
+00:18:14,880 --> 00:18:18,080
+الجماعة تبني العواملين ولا ..؟ الجماعة تبني عن
+
+182
+00:18:18,080 --> 00:18:21,780
+تكلفة المبيعات لغاية ما .. لغاية مصاريف أخرى طب
+
+183
+00:18:21,780 --> 00:18:24,920
+ليش الإيراد لأ؟ الإيراد مش نقص التكليف مش تكاليف
+
+184
+00:18:24,920 --> 00:18:29,320
+مالكه الجماعة الإيراد مش تكليف مالكه الإيراد ليس
+
+185
+00:18:29,320 --> 00:18:34,240
+تكلفة الإيراد كمية في السعر بدنا نجيب صفر الربح
+
+186
+00:18:34,240 --> 00:18:36,720
+الكلام اللي أدخلته في دار المالية صفر الربح عبارة
+
+187
+00:18:36,720 --> 00:18:41,700
+عن الإيراد نقص التكليف الإيراد هاجة والتكليف هاجة
+
+188
+00:18:41,700 --> 00:18:45,090
+تانيةيعني صرف النتيجة في المجموع المصاريف و لا
+
+189
+00:18:45,090 --> 00:18:49,610
+الإيراد؟ العكس، الإيراد في المجموع المصاريف عاملها
+
+190
+00:18:49,610 --> 00:18:54,090
+اللي كنت بخط لحمها هكذا، الأخضر من بعضه، من وين
+
+191
+00:18:54,090 --> 00:18:57,990
+جيب نصر في النتيجة، الأخضر من بعضه، في أي رقم على
+
+192
+00:18:57,990 --> 00:19:04,090
+الصابورة مش واضح، تفضلي مثل حلوة إجمال المصاريف،
+
+193
+00:19:04,090 --> 00:19:08,750
+كلهم معادل الأخرى، مستمردهم كمان؟ كلهم، إجمال
+
+194
+00:19:08,750 --> 00:19:12,470
+المصاريف، مقدرش أسيبها الأخرى، الأخرى في القرارات
+
+195
+00:19:13,340 --> 00:19:17,320
+لكن في العمليات الحسابية بتنحط لإني هدفعها ماشي من
+
+196
+00:19:17,320 --> 00:19:21,680
+وين جيبنا أجمع التكليف يا أخوات هذه جماعتها دول
+
+197
+00:19:21,680 --> 00:19:33,220
+فجيبت هذه ماشي من وين جيب الصف النتيجة فرحت هذا من
+
+198
+00:19:33,220 --> 00:19:37,520
+هذا أكتبهم
+
+199
+00:19:41,820 --> 00:19:48,580
+صح في النتيجة؟ لسه يا قبض احنا ماخترناش لسه بنفكر
+
+200
+00:19:48,580 --> 00:19:53,340
+بنعمل عداسة بنفكر الان في اي رقم عصبه ولا مش واضح
+
+201
+00:19:53,340 --> 00:19:56,300
+من ون اجاه هذه قايمة داخل قايمة داخل دايما إيراد
+
+202
+00:19:56,300 --> 00:20:06,350
+نقص التكلفة ماشي الان طبعا تحت الشغل تبعناتحت
+
+203
+00:20:06,350 --> 00:20:10,350
+جدولنا، قعدت تدخل؟ هنتاخد القرار هنتاخد ايش؟
+
+204
+00:20:10,350 --> 00:20:16,210
+القرار عشان نتاخد القرار نفكر نونا، يلا نفكر نفكر
+
+205
+00:20:16,210 --> 00:20:20,550
+ولا بلاش؟ يلا نفكر نبدأ نفكر بصوت عالي ولا نستنى
+
+206
+00:20:20,550 --> 00:20:27,610
+شوية؟ في حد لسه بكتب؟ في حد مش فاهم كيف حلنا
+
+207
+00:20:27,610 --> 00:20:28,450
+السؤال؟
+
+208
+00:20:34,790 --> 00:20:40,350
+أخر عمود؟ طرحنا
+
+209
+00:20:40,350 --> 00:20:46,030
+صح في النتيجة من بعض عشرين،
+
+210
+00:20:46,030 --> 00:20:53,530
+كيف يا جماعة؟ 130
+
+211
+00:20:53,530 --> 00:20:55,110
+نقص 145
+
+212
+00:20:59,920 --> 00:21:02,780
+ع الفكرة احنا ماجمعناش حاجة، طول الشغل فيش فيه
+
+213
+00:21:02,780 --> 00:21:06,060
+جمعة، الفرح هي جمعة تطرحي الجديد من القديم من
+
+214
+00:21:06,060 --> 00:21:09,280
+القديم من الجديد، عادي، أهمش تكون فاهم الأرقام،
+
+215
+00:21:09,280 --> 00:21:13,080
+فاهمت الأرقام، تقدر تحلي الصح و تخلق قرار صحيح،
+
+216
+00:21:13,080 --> 00:21:17,060
+ماشي؟ الحاجة الوحيدة اللي جمعناها أجمالي التكاليف
+
+217
+00:21:17,060 --> 00:21:21,780
+فقط، حتى جمعناها بشكل إيش؟ رأسي، ماجمعناش بشكل
+
+218
+00:21:21,780 --> 00:21:22,680
+فقط، نجمعش أصلا
+
+219
+00:21:26,590 --> 00:21:31,810
+التحليل التفاضلي عبارة عن حاسل طرح التسويق القديم
+
+220
+00:21:31,810 --> 00:21:37,410
+ناقص للجديد العمود هذا ناقص هذا التكاليف
+
+221
+00:21:37,410 --> 00:21:50,250
+تكاليف دائما سالبة دائما يلّا
+
+222
+00:21:50,250 --> 00:21:53,030
+نفكر بصوت عالي عشان نكتب القرار لإن هو السؤال بدوش
+
+223
+00:21:53,030 --> 00:21:56,670
+يعني نقعد أحسببدي انا اتخذ القرار عشان انا اتخذ
+
+224
+00:21:56,670 --> 00:22:00,710
+القرار لازم احسب يعني السؤال مش هقول ان احسب ايه
+
+225
+00:22:00,710 --> 00:22:04,210
+هقولك اتخذ القرار طبعا كيف هتاخده؟ بتحسب حسبنا و
+
+226
+00:22:04,210 --> 00:22:08,550
+خلصنا في اي مشكلة في الحل اعده تاني؟ اي مشكلة في
+
+227
+00:22:08,550 --> 00:22:14,850
+الحل؟ اي مشكلة؟ الإيرادات تُطرح من التكاليف لحتى
+
+228
+00:22:14,850 --> 00:22:19,090
+نجيب صافقاش النتيجة مستحيل نجمع الإيراد مع
+
+229
+00:22:19,090 --> 00:22:22,970
+التكاليف معناه الحمد لله مش هنعمل حاجةنسمع التفكير
+
+230
+00:22:22,970 --> 00:22:26,890
+بصوت عالي، تفضّال يا هودا؟ يعني راح نختار البديل
+
+231
+00:22:26,890 --> 00:22:30,550
+التاني، ليش؟ لإن هوفر علينا هو 35% لإن لو استخدمنا
+
+232
+00:22:30,550 --> 00:22:34,850
+احنا تجليق القديم، تسويق القديم، راح يعطيني صف
+
+233
+00:22:34,850 --> 00:22:38,390
+النتيجة 20 ألف، لكن تسويق الجديد 55 ألف، لما
+
+234
+00:22:38,390 --> 00:22:42,450
+اترحناه من بعض، طلع عندي توفير في هاي المصاريف 35%
+
+235
+00:22:42,450 --> 00:22:47,050
+يعني صف النتيجة من 20 ل 55، زاد ولا قل؟ زاد ممتاز،
+
+236
+00:22:47,050 --> 00:22:50,870
+زاد بجداش؟ 35% ممتاز، شكرا يا عزيزي، ننصح بإيش؟
+
+237
+00:22:51,180 --> 00:22:59,160
+بالتسويق الجديد شكرا أيضا مين حابب يفكر؟ بس؟ ماشي
+
+238
+00:22:59,160 --> 00:23:07,500
+تعالوا نقارن التسويق القديم إيراداتنا كانت 150 لو
+
+239
+00:23:07,500 --> 00:23:10,380
+انتقلنا على التسويق الجديد هزيده ولا هتقل؟ هزيد
+
+240
+00:23:10,380 --> 00:23:14,340
+مانكش اللقب السالب هذا تقولنا هذا عامل حسابية هزيد
+
+241
+00:23:14,340 --> 00:23:18,950
+50 ألف مش هانا أولى فيهاأه أنا أولى فيها ال 50 ألف
+
+242
+00:23:18,950 --> 00:23:24,470
+نكمل تكاليف مبيعاتنا 60 هي تكاليف لو .. يعني
+
+243
+00:23:24,470 --> 00:23:28,630
+مبدأيه أن احنا وفدنا على التسويق الجديد لأن
+
+244
+00:23:28,630 --> 00:23:34,770
+إيراداتنا زادت ضايلة التكاليف كانت 60 صارت 80
+
+245
+00:23:34,770 --> 00:23:41,010
+زيادة التكاليف مش لصالحنا طيب 20 خلوها شوية مصاريف
+
+246
+00:23:41,010 --> 00:23:47,540
+الإعلان كانت 20 حصير 10قلت، هذه مصاريف يعني، تكليف
+
+247
+00:23:47,540 --> 00:23:54,380
+يعني لصالحنا، طب كويس مصاريف عمومي خمستاشر لش جيد
+
+248
+00:23:54,380 --> 00:23:59,400
+عشرين زادت، وحش، طيب مصاريف أخرى قولنا مش هنتطلع
+
+249
+00:23:59,400 --> 00:24:02,200
+عليها، لا زادت ولا قلت، إذا هذه غير تفضلية، لا تصل
+
+250
+00:24:02,200 --> 00:24:06,600
+في اتخاذ أيش القرار، هان، لكن في الحسابة دخلها،
+
+251
+00:24:06,600 --> 00:24:10,920
+يعني هذه الـ zero بضل ماشية، بقولش زادت ولا قلت،
+
+252
+00:24:10,920 --> 00:24:18,250
+الإجمالي، تسويق القديم 130تسويق الجديد 145 بناء
+
+253
+00:24:18,250 --> 00:24:22,370
+على بند التكاليف لا داعي للتسويق الجديد بناء على
+
+254
+00:24:22,370 --> 00:24:25,930
+بند التكاليف مافيش داعي ليش مافيش داعي؟ لأنها زادت
+
+255
+00:24:25,930 --> 00:24:29,450
+وش الطبيعي أنها زيد الآن النقطة الحازمة صار في
+
+256
+00:24:29,450 --> 00:24:36,430
+النتيجة في التسويق القديم أنا ربحانة 20 ألف ماشي
+
+257
+00:24:36,430 --> 00:24:41,650
+في التسويق الجديد لو أخدنا هنربح 55 هل النقطة
+
+258
+00:24:41,650 --> 00:24:46,970
+الحازمة اللي بناء عليها هتاخد القرار؟عشرين، ناقص
+
+259
+00:24:46,970 --> 00:24:49,330
+خمسة و خمسين، خمسة و تلاتين ألف، خمسة و تلاتين
+
+260
+00:24:49,330 --> 00:24:51,470
+ألف، خمسة و تلاتين ألف، خمسة و تلاتين ألف، خمسة و
+
+261
+00:24:51,470 --> 00:24:54,730
+تلاتين ألف، خمسة و تلاتين ألف، خمسة و تلاتين ألف،
+
+262
+00:24:54,730 --> 00:24:58,830
+خمسة و تلاتين ألف، خمسة و تلاتين ألف، خمسة و
+
+263
+00:24:58,830 --> 00:25:01,490
+تلاتين ألف، خمسة و تلاتين ألف، خمسة و تلاتين ألف،
+
+264
+00:25:01,490 --> 00:25:07,810
+خمسة و تلاتين ألف، خمسة و تلاتين ألف، خمسة
+
+265
+00:25:07,810 --> 00:25:10,770
+و تلاتين ألف، خمسة و تلاتين ألف، خمسة و تلاتين
+
+266
+00:25:10,770 --> 00:25:16,720
+ألف، خإذا ليش وفقناه؟ لأنه هيحقق إليه ربح خمسة و
+
+267
+00:25:16,720 --> 00:25:22,700
+تلاتين ألف إيش دولار، بالرغم من زيادة التكاليف،
+
+268
+00:25:22,700 --> 00:25:31,540
+لأنه هيظل ربحا أخدتي بالك ولا أعيدها؟ أعيدها تاني؟
+
+269
+00:25:31,540 --> 00:25:38,400
+أعيد التعليق ولا أعيد الشرح؟ التعليقمين كتبوا
+
+270
+00:25:38,400 --> 00:25:42,600
+دلالة قائمية؟ ننصح صاحب هذه المؤسسة بالانتقال
+
+271
+00:25:42,600 --> 00:25:49,720
+الاجتماعي في سؤالها، فضل ده بس 200 نقص 145 200 ألف
+
+272
+00:25:49,720 --> 00:25:55,340
+نقص 145 200 ألف نقص 145؟ ليش؟ مالها؟ ماتيش خمسة و
+
+273
+00:25:55,340 --> 00:25:59,740
+خمسين؟ أنت اللي أعطيتني الرقم أحسن احسميها أه دلاش
+
+274
+00:25:59,740 --> 00:26:05,670
+يعني احسميها آية آية أحسنيعني لو أسمانك ده لتقلط
+
+275
+00:26:05,670 --> 00:26:09,530
+خلاص خلاص؟ لأ لأ بالذات أنا .. ماشي، في أي سؤال؟
+
+276
+00:26:09,530 --> 00:26:13,610
+مش مشكلة، في أي سؤال؟ يالا يا دلال معلش قطعناك
+
+277
+00:26:13,610 --> 00:26:17,370
+يعني، تتفضلي ننصح صاحب هذه المؤسسة بالانتقال
+
+278
+00:26:17,370 --> 00:26:21,830
+للتسويق الجديد لأنه سيحقق له ربح خمسة و تلاتين ألف
+
+279
+00:26:21,830 --> 00:26:28,220
+دولار بغير من زيادة التكاليف نعيدها تاني؟خودي بالك
+
+280
+00:26:28,220 --> 00:26:31,000
+سواء عملتي البديل الجيد نقص القديم أو القديم نقص
+
+281
+00:26:31,000 --> 00:26:34,300
+الجيد، هيطلع نفس الحل الأرقام، لكن الإشارات هي
+
+282
+00:26:34,300 --> 00:26:38,540
+اللي هتختلف، ماشي؟ أهمش هي تكوني فاهمة أرقامها دي
+
+283
+00:26:38,540 --> 00:26:44,220
+إيش، الإيرادات ان زادت ممتاز، الإيرادات ان قلت وحش
+
+284
+00:26:44,220 --> 00:26:50,060
+غير ملغوف فيه، التكاليف ان زادت سيء، التكاليف ان
+
+285
+00:26:50,060 --> 00:26:55,970
+قلت ممتازالإيراد أو التكاليف إن لم يتغير لا يصلح
+
+286
+00:26:55,970 --> 00:27:00,690
+لاتخاذ إيش؟ القرار لا يصلح لاتخاذ القرار واضح ولا
+
+287
+00:27:00,690 --> 00:27:07,070
+نهيتها؟ واضح نهيت تاني؟ نهيت إذا التكلفة الأولى
+
+288
+00:27:07,070 --> 00:27:10,310
+كانت التفاضلية واخدنا عليها نتال؟ نشوف مع بعض
+
+289
+00:27:10,310 --> 00:27:15,730
+تاني؟ أكمل ولا أعيد؟ التفاضلية أيه هو ما أفضل؟
+
+290
+00:27:15,730 --> 00:27:19,310
+تكليف الأقل هو الأفضل، الإيرادات والأرباح الأعلى
+
+291
+00:27:19,310 --> 00:27:19,850
+هو الأفضل
+
+292
+00:27:23,300 --> 00:27:25,640
+النوع التاني من التكاليف لغاية التخطيط اللي هي
+
+293
+00:27:25,640 --> 00:27:32,460
+التكاليف الغارقة غرجت خلاص يالا يا أسلام أبو سيد
+
+294
+00:27:32,460 --> 00:27:36,460
+قولينا لو سمحتها التكاليف الغارقة تكاليف حدث في
+
+295
+00:27:36,460 --> 00:27:39,780
+الماضي لا يمكن تبليغها في أي قرار حالي أو مستقبل
+
+296
+00:27:39,780 --> 00:27:43,020
+ولا يمكن تبليغها بأي قرار سواء في الحرب أو في
+
+297
+00:27:43,020 --> 00:27:47,040
+المستقبل فهي تكاليف التفاضل تكاليف غير أياش تفاضل
+
+298
+00:27:47,040 --> 00:27:53,590
+الان لما خلصت التنوية العامةو جيتوا تسجلوا في
+
+299
+00:27:53,590 --> 00:28:02,490
+الجامعة دفعتوا سوم عشرين دينار غير مستردى، لأ سوم
+
+300
+00:28:02,490 --> 00:28:09,550
+التسجيل لسه اسمه حاجز مقرع عشرين دينار؟ غير
+
+301
+00:28:09,550 --> 00:28:18,050
+مستردى، هي هذه إيش معنى غير مستردى؟ لو عطيتني ياه
+
+302
+00:28:18,050 --> 00:28:24,860
+ولا عمك هتاخديهابنسميها تكاليف غارقة، بمعنى بعد ما
+
+303
+00:28:24,860 --> 00:28:30,400
+اتدفعت العشرين دينار إلي أنا كمؤسسة و مكتوب غير
+
+304
+00:28:30,400 --> 00:28:35,480
+مستردة و بدك تروح يعنى نفسك اللي لا يحق لك
+
+305
+00:28:35,480 --> 00:28:40,380
+المطالبة ما تشايف غير مستردة إذا التكاليف الغارقة
+
+306
+00:28:40,380 --> 00:28:44,000
+هي التكاليف اللي إحنا لو دفعناها صعب أرجع، خلاص
+
+307
+00:28:44,000 --> 00:28:50,210
+راحت عليناماشى هل يا حقلة ماتيش تتخرجى وتاخد
+
+308
+00:28:50,210 --> 00:28:52,510
+الشهادة ماتيش تحكى بإن ال 20 دي نار اللي دفعتهم
+
+309
+00:28:52,510 --> 00:28:59,550
+زمان؟ إذا التكاليف إيش؟ غارقة، خلصناها لا يمكن
+
+310
+00:28:59,550 --> 00:29:03,930
+تغييرها، يعني استردادها بأي قرر، لا حالي ولا
+
+311
+00:29:03,930 --> 00:29:07,510
+مستقبلي لا هنيجي اليوم نقولك تعالى خدوا ال 20 دي
+
+312
+00:29:07,510 --> 00:29:11,330
+نار اللي دفعتيهم أول الزمانات ولا هنقولك في
+
+313
+00:29:11,330 --> 00:29:15,950
+المستقبل تعالى خدواه، خلاص انتهت
+
+314
+00:29:16,960 --> 00:29:22,000
+إيه؟ لإن هي تكاليف غالجانة، ليش تكاليف غالجانة؟
+
+315
+00:29:22,000 --> 00:29:26,140
+بمجابة الدفع لأستطيع استرجاعها و التأثير فيها،
+
+316
+00:29:26,140 --> 00:29:28,420
+بغير أشتغل و أقول طب خلاص خلّي أليكم 15 دنيا و
+
+317
+00:29:28,420 --> 00:29:33,800
+أعطوني الخمسة، مانفعش، بمجابة الدفع لا يمكن ايش
+
+318
+00:29:33,800 --> 00:29:40,480
+استرداد، لأ اليوم ولا بقرا، بتنسيها يعني، لإن هي
+
+319
+00:29:40,480 --> 00:29:47,710
+تكاليف إيش؟ غير تفاضليةهي تكاليف غير تفاضلية،
+
+320
+00:29:47,710 --> 00:29:55,370
+العيش غير تفاضلية، لا أنا استطيع التأثير فيها،
+
+321
+00:29:55,370 --> 00:29:58,190
+بقدرش أقولهم أعطوني ياها أو رجعوها أو أنا خاصة
+
+322
+00:29:58,190 --> 00:30:03,090
+مديشياكوا أو بقدر أروح جامعة تانية؟ واضحة اللي
+
+323
+00:30:03,090 --> 00:30:09,230
+عيدها؟ عيدة تانية؟ بنسميها تكاليف غارقة، يعني غرجت
+
+324
+00:30:09,230 --> 00:30:17,750
+في البحرانت اشتريتي قبل خمس سنوات جوال بألفين
+
+325
+00:30:17,750 --> 00:30:22,710
+شكل، إجيتك بإيه اليوم؟ هل بتبقى بإيه بألفين شكل؟
+
+326
+00:30:22,710 --> 00:30:28,350
+خلاص، أبسط أجيب خمسين كمان، إذا التكاليف حددت في
+
+327
+00:30:28,350 --> 00:30:31,070
+الماضي، لا نستطيع أن نتأثر فيها، لا اليوم ولا
+
+328
+00:30:31,070 --> 00:30:36,310
+بكرا، بنسميها تكاليف إيش؟ قارقةهل هي تفاضلية ام
+
+329
+00:30:36,310 --> 00:30:40,730
+غير تفاضلية؟ تنفعش تجيلي بعد خمس سنين تبيعي الجواي
+
+330
+00:30:40,730 --> 00:30:43,410
+و تقوليلي أنا شهيته قبل خمس سنين بألفان و أنا مال
+
+331
+00:30:43,410 --> 00:30:50,330
+لا يمكن تأثير فيها، إذا هي غير إياش تفاضلية صح و
+
+332
+00:30:50,330 --> 00:30:55,810
+غط لو سمحتي من
+
+333
+00:30:55,810 --> 00:31:02,390
+الأمثلة من الأمثلة على التكاليف الغارقة
+
+334
+00:31:08,330 --> 00:31:19,010
+الرسوم الدراسية اللتي يدفعها الطالب مين
+
+335
+00:31:19,010 --> 00:31:21,810
+حاب يجاوب، بس مش تخمين صح و غلط، يا صح يا غلط، يلا
+
+336
+00:31:21,810 --> 00:31:30,230
+يسرق العبارة
+
+337
+00:31:30,230 --> 00:31:34,550
+خاطئةاحنا التاولة ما شرحنا ما شرحناش عن الوصوم
+
+338
+00:31:34,550 --> 00:31:39,110
+الدراسية، شرحنا عن وصوم الحجز أو وصوم التسجيل،
+
+339
+00:31:39,110 --> 00:31:39,550
+بتختلف
+
+340
+00:31:44,210 --> 00:31:55,010
+أه أه في ممكن تاخديها لأ في فرج اه
+
+341
+00:31:55,010 --> 00:32:06,690
+ماهم هدول .. ماهم هدول الرسوم الدراسية الرسوم
+
+342
+00:32:06,690 --> 00:32:11,470
+الدراسية اللي هي خمستاشر دنار في عدة ساعاتماشي،
+
+343
+00:32:11,470 --> 00:32:13,590
+لكن انتوا شرحنا اللي هي التكاليف اللي غلق اللي هي
+
+344
+00:32:13,590 --> 00:32:17,510
+ال 20 دنار اللي دفعتها لما كان عمري 18 سنة و أخدت
+
+345
+00:32:17,510 --> 00:32:20,490
+شانطة و أخدت تزمة، هي هذي اللي بحكي عنها، هذي مش
+
+346
+00:32:20,490 --> 00:32:25,230
+وصوم دراسية، هذي مش وصوم دراسية أنا الآن خلصت
+
+347
+00:32:25,230 --> 00:32:30,750
+توجيه، بدي أحجز في تلت أربع جامعات، وبعدين أختار
+
+348
+00:32:30,750 --> 00:32:34,290
+جامعة، فكل جامعة بدفع 20 دنار، 20 دنار، 20 دنار،
+
+349
+00:32:34,290 --> 00:32:39,600
+20 دنار، لا يحق إلي استرداد أي واحدة فيهمتكاليف
+
+350
+00:32:39,600 --> 00:32:43,420
+غارقة العشرين دينار مش رسوم دراسة لأ لسه مااخدونها
+
+351
+00:32:43,420 --> 00:32:46,540
+اش اصلا لسه اسمي مانزلش فيها جامعة و لا وان بدي
+
+352
+00:32:46,540 --> 00:32:51,460
+اروح و انا لسه ماقررتش ماشي هذه اللي بحكي عنها هذه
+
+353
+00:32:51,460 --> 00:32:57,160
+التكاليف الغارقة لكن انا روحت دفعت رسوم تلاتمين
+
+354
+00:32:57,160 --> 00:33:01,040
+دينار في جامعة و بعد يومين قررت اروح الجامعة
+
+355
+00:33:01,040 --> 00:33:04,940
+التانية بحق اللي اخدهم بصحى تلاتمين دي بتاعتى و
+
+356
+00:33:04,940 --> 00:33:08,740
+اروح الجامعة التانيةباختلف عن بعض يعني، في فرق بين
+
+357
+00:33:08,740 --> 00:33:11,900
+الرسوم الدراسية و الرسوم العشرين ليلة زي ما حكيته
+
+358
+00:33:11,900 --> 00:33:16,580
+حجز مقعد زي بس الكهربا مثلا، ان هذه الرسوم اللي كل
+
+359
+00:33:16,580 --> 00:33:19,200
+شهر تدفع سواء استهلاكتي أو لا استهلاكتي، يعني هي
+
+360
+00:33:19,200 --> 00:33:22,120
+عليكي هذه اللي تاخد فرقها أما إذا أقعد مانت في
+
+361
+00:33:22,120 --> 00:33:28,040
+استهلاك، هذه بيصير رسوم عادية بس الآن صار
+
+362
+00:33:28,040 --> 00:33:34,670
+في مشاكل، أنه ليش المستهلك يدفع رسوم تابعة؟لأ احنا
+
+363
+00:33:34,670 --> 00:33:40,230
+مانعش أنه .. بديش يصير لبس أنا بين المتدرجة أو
+
+364
+00:33:40,230 --> 00:33:43,510
+المختلطة معلش و هدى .. هدى إشي و هدى كإشي انا بحكي
+
+365
+00:33:43,510 --> 00:33:46,590
+مثلا يعني تقريب للإشي .. اه تقريب .. هي صعبة لهد
+
+366
+00:33:46,590 --> 00:33:53,250
+درجة؟ لأ يعني أسمها شرت سيارة قبل عشر سنين السيارة
+
+367
+00:33:53,250 --> 00:33:59,190
+بتاعتها كانت تلاتين ألف دولار إيش هتتبيعها؟بعد عشر
+
+368
+00:33:59,190 --> 00:34:04,770
+سنين هل هتقول لزبون المشتري انا اشتريتها في 30
+
+369
+00:34:04,770 --> 00:34:12,090
+ألف؟ اشتخل هو، لأ، مسميها تكريف رارقة، ماشي، معايا
+
+370
+00:34:12,090 --> 00:34:16,970
+ولا عيدها؟ وصلت ولا عيدها تاني؟ خلاص، يعني انت
+
+371
+00:34:16,970 --> 00:34:21,430
+اشتريت بلوزة أبنين شاكر، ولبستيها، وبعدين أخدتيها
+
+372
+00:34:21,430 --> 00:34:26,450
+ورمتيها، خلاص، صادق جديد، هل هتستردي المسار؟ خلاص
+
+373
+00:34:26,450 --> 00:34:33,580
+اسمها رارقة، غرقت يعنيواضحة ولا عيدها؟ عيدها تاني؟
+
+374
+00:34:33,580 --> 00:34:38,680
+بعيدها مش مشكلة مش هذا ماحساها كل يوم الحمد لله
+
+375
+00:34:38,680 --> 00:34:50,400
+إحساس خاطئ ولا إحساس صادق؟ ماشي في عندنا مثال في
+
+376
+00:34:50,400 --> 00:34:52,980
+عندنا مثال إذا بلغت
+
+377
+00:34:55,860 --> 00:35:02,020
+تكلفة شراء فيلتر المياه أكتب المعطلات على الصابورة
+
+378
+00:35:02,020 --> 00:35:07,360
+إذا بلغت حاضر يعني إذا بلغت تكلفة شراء فيلتر
+
+379
+00:35:07,360 --> 00:35:11,160
+المياه قبل
+
+380
+00:35:11,160 --> 00:35:23,480
+خمس سنوات تمانمائة دولار ولدينا
+
+381
+00:35:26,010 --> 00:35:31,150
+تلات بدائل واحد
+
+382
+00:35:31,150 --> 00:35:34,650
+بيع
+
+383
+00:35:34,650 --> 00:35:39,130
+الفلتر ب
+
+384
+00:35:39,130 --> 00:35:43,990
+500 دولار اثنين
+
+385
+00:35:43,990 --> 00:35:48,090
+استعماله
+
+386
+00:35:48,090 --> 00:35:54,410
+لتنقية مياه بركة الصباحة
+
+387
+00:36:01,160 --> 00:36:09,180
+بتكاليف تشغيل الفين دولار ومن
+
+388
+00:36:09,180 --> 00:36:19,800
+الممكن بيعه في هذه الحالة بين قرصين لنفس الغرض
+
+389
+00:36:19,800 --> 00:36:25,280
+اللي هو تنقية مياه بركة استباحة بتمان تلاف دولار
+
+390
+00:36:25,280 --> 00:36:36,820
+نقطة تمان تلافالحالة التالتة أو رقم تلاتة استخدامه
+
+391
+00:36:36,820 --> 00:36:42,900
+لتنقية مياه
+
+392
+00:36:42,900 --> 00:36:56,900
+الشرب بتكاليف تشغيل ألف دولار ومن الممكن بيعه
+
+393
+00:36:56,900 --> 00:36:58,060
+لنفس الغرض
+
+394
+00:37:00,670 --> 00:37:06,910
+ب 4000 دولار سؤال
+
+395
+00:37:06,910 --> 00:37:14,830
+أي البدائل تختارين؟
+
+396
+00:37:14,830 --> 00:37:26,490
+ممكن نطلع و نفكر من غير ما نعمل حمالية حسابية حلو
+
+397
+00:37:26,490 --> 00:37:31,880
+ولا لازم أكتب المعطيات؟عشان الوجد ما نبدأ حله و لا
+
+398
+00:37:31,880 --> 00:37:37,200
+أكتب مكان سؤال؟ ماشي الحل ع السريع طبعا انا لو
+
+399
+00:37:37,200 --> 00:37:39,440
+عنده خبرة في الشراطة هذه ممكن ماعملش حملة حسابية،
+
+400
+00:37:39,440 --> 00:37:45,160
+واحد، اتنين، اذا كان بديل عندنا تلاتة، بيع فقط،
+
+401
+00:37:45,160 --> 00:37:53,120
+نقول مياه، شرب، بركة سباحة، هاي البدالي يا أخوات،
+
+402
+00:37:53,120 --> 00:37:58,310
+ماشي؟ أول حاجة الإيراددايما الإيرادة هو الحاجة لو
+
+403
+00:37:58,310 --> 00:38:06,990
+بيقعدنا بس قداش إيرادك في السؤال؟ طب
+
+404
+00:38:06,990 --> 00:38:13,990
+لو أخدناني مياه الشرب؟ أربعة تلاتة ممتاز بنجيبس
+
+405
+00:38:13,990 --> 00:38:17,350
+الأرقام القاعدين اللي معاكي طب فرقة السباحة؟ تمان
+
+406
+00:38:17,350 --> 00:38:22,810
+تلاتة بعد إيرادة إيش بيجيني؟ تكاريف
+
+407
+00:38:26,030 --> 00:38:29,530
+تكاليف التشغيل، لو بأنها مافيش تكاليف التشغيل،
+
+408
+00:38:29,530 --> 00:38:35,190
+مياه الشرب كدهش تكاليف تشغيلها؟ ألف وبلقة السباحة؟
+
+409
+00:38:35,190 --> 00:38:41,350
+ألفين أعطينا صرف النتيجة، لحظة يعني هو قبل ما يبقى
+
+410
+00:38:41,350 --> 00:38:45,290
+.. مياه .. قبل ما يبقى على مياه الشرب أربعة ألف،
+
+411
+00:38:45,290 --> 00:38:47,330
+بتقولنا لازم نحط اللي هي الألف؟
+
+412
+00:38:49,930 --> 00:38:53,250
+كيف يعني؟ يعني كده شغلة اللي بيبقى مثلا دولار اربع
+
+413
+00:38:53,250 --> 00:38:56,390
+تلاف .. اه لو بدي استخدم مياه الشرب هو هجيبلي ..
+
+414
+00:38:56,390 --> 00:38:59,790
+يعني عامل .. اناق مياه الشرب وابيع للناس هجيبلي
+
+415
+00:38:59,790 --> 00:39:03,610
+هذا اربع تلاف بس تكليف تشغيل ال filter ألف هو بده
+
+416
+00:39:03,610 --> 00:39:07,490
+تكليف الكهرب وصيان وش بعد هذي لو بدي لبركة السباحة
+
+417
+00:39:07,490 --> 00:39:10,910
+يعني الناس تيجي تسبح عندى وابصريش تكليف التشغيل
+
+418
+00:39:10,910 --> 00:39:15,530
+ألفين طالع صاف النتيجة خمسمية نقص ولاش خمسمية؟
+
+419
+00:39:15,530 --> 00:39:17,370
+خمسمية تلات طلعة
+
+420
+00:39:29,820 --> 00:39:36,640
+سهلة أه؟ أه وضت في السؤال تكاليف .. في سؤال؟ من
+
+421
+00:39:36,640 --> 00:39:42,060
+وين جبناهم؟ بين قصير معناها طبعا وضت في السؤال
+
+422
+00:39:42,060 --> 00:39:49,360
+تكاليف غارقة مين هي؟ تمانمان دولار ممتاز .. ممتاز
+
+423
+00:39:49,360 --> 00:39:54,800
+يا عزيزي خلصتوا أ لسه؟ أن أكون بطيئين
+
+424
+00:39:59,180 --> 00:40:03,260
+ممكن طالبة تيجي تلقي نظرة على السؤال مش على
+
+425
+00:40:03,260 --> 00:40:06,720
+الإجابة و تلقي نظرة على السؤال تبع التسويق اللي
+
+426
+00:40:06,720 --> 00:40:10,460
+قبل شوية هتلاقي في التسويق أخدنا كل الأرقام
+
+427
+00:40:10,460 --> 00:40:15,860
+استخدمناها في الحل في سؤال ال filter لو ألقت نظرة
+
+428
+00:40:15,860 --> 00:40:20,960
+هتلاقي فيه رقم مادخلش في الحل اللي هو مين يا نور؟
+
+429
+00:40:20,960 --> 00:40:24,360
+أول
+
+430
+00:40:24,360 --> 00:40:29,120
+رقم أخدتيهاللي هو تمنمية الدولار طب هذا ليش مانحطش
+
+431
+00:40:29,120 --> 00:40:32,760
+في الحل؟ لإن استخدامهم السنوات لأنه قبل استخدامهم
+
+432
+00:40:32,760 --> 00:40:38,200
+السنوات إذا التمنمية الدولار هي تكاليف إيش؟ رارقة
+
+433
+00:40:38,200 --> 00:40:41,200
+تمنمية الدولار تكاليف رارقة مادخلناهاش على الحل
+
+434
+00:40:41,200 --> 00:40:47,180
+ليش مادخلتيها على الحل؟ لأنها غير تفاضلية إيش يعني
+
+435
+00:40:47,180 --> 00:40:52,140
+غير تفاضلية؟ لأ تصلح في اتخاذ إيش؟ القرار طب مثلا
+
+436
+00:40:52,140 --> 00:40:54,820
+.. مش كل .. مثلا دوخر اللي استبعدناه شوية شوية
+
+437
+00:40:54,820 --> 00:40:58,640
+واحدة واحدة .. شوية شويةإنه هجيطه شرع 800 دولار،
+
+438
+00:40:58,640 --> 00:41:02,520
+لو هو بايعه بيقول ما يعني، هو هيبيعه بـ500، ماشي،
+
+439
+00:41:02,520 --> 00:41:06,760
+هيكون بس تكلفة الغارقة 300 هو هيبيعه بـ500 بعد 5
+
+440
+00:41:06,760 --> 00:41:10,260
+سنين، ماشي أه يعني كل الـ800 دولار صارت تكلفة
+
+441
+00:41:10,260 --> 00:41:13,780
+الغارقة، يعني مش كلها خسرنا، لأ كله هو .. هذا إشي
+
+442
+00:41:13,780 --> 00:41:16,440
+معنوي، انا 300، بقى إشي معنوي، لكن من ناحية
+
+443
+00:41:16,440 --> 00:41:19,580
+محاسبية لأ يعني، هذه حاجة معنوية الواحد يعني يبوش
+
+444
+00:41:19,580 --> 00:41:24,160
+بالخاطر حاله فيها، يعني كأن يخسر الـ300 أه، بس من
+
+445
+00:41:24,160 --> 00:41:28,570
+ناحية محاسبية لأ، واضح؟في أي سؤال تانى؟ في أي
+
+446
+00:41:28,570 --> 00:41:33,430
+سؤال؟ أي سؤال يعطيكوا العافية
+