passages.id: 26509
passages.type: title
passages.text: Seizure activity with imipenem therapy: incidence and risk factors.
passages.id: 26510
passages.type: abstract
passages.text: Two elderly patients with a history of either cerebral vascular accident (CVA) or head trauma and no evidence of renal disease developed seizures while receiving maximum doses of imipenem/cilastatin. Neither patient had reported previous seizures or seizure-like activity nor was receiving anticonvulsant agents. All seizures were controlled with therapeutic doses of phenytoin. Both patients had received maximum doses of other beta-lactam antibiotics without evidence of seizure activity.