passages.id: 21009
passages.type: title
passages.text: Two prodrugs of potent and selective GluR5 kainate receptor antagonists actives in three animal models of pain.
passages.id: 21010
passages.type: abstract
passages.text: Amino acids 5 and 7, two potent and selective competitive GluR5 KA receptor antagonists, exhibited high GluR5 receptor affinity over other glutamate receptors. Their ester prodrugs 6 and 8 were orally active in three models of pain: reversal of formalin-induced paw licking, carrageenan-induced thermal hyperalgesia, and capsaicin-induced mechanical hyperalgesia.