passages.id: 1574
passages.type: title
passages.text: Remodelling of nerve structure in experimental isoniazid neuropathy in the rat.
passages.id: 1575
passages.type: abstract
passages.text: The neuropathy caused by a single dose of isoniazid in rats was studied with a computer-assisted morphometric method. Scatter diagrams of the g ratio (quotient fibre diameter/axon diameter) define regenerating fibres as a distinct population, distinguishable from the surviving fibres by reduced sheath thickness and reduced axon calibre. There was also evidence of a subtle direct toxic effect on the entire fibre population, causing axon shrinkage masked by readjustment of the myelin sheath.