passages.id: 25501
passages.type: title
passages.text: Cardiac toxicity of 5-fluorouracil. Report of a case of spontaneous angina.
passages.id: 25502
passages.type: abstract
passages.text: We report a case of a patient with colon carcinoma and liver metastasis who presented chest pain after 5-fluorouracil (5-FU) administration. Clinical electrocardiographic evolution was similar to that observed in Prinzmetal's angina, and chest pain promptly resolved with nifedipine. These data suggest that coronary spasm may be the cause of cardiotoxicity due to 5-FU, and that calcium antagonists may probably be used in the prevention or treatment of 5-FU cardiotoxicity.