passages.id: 1018
passages.type: title
passages.text: Lamotrigine associated with exacerbation or de novo myoclonus in idiopathic generalized epilepsies.
passages.id: 1019
passages.type: abstract
passages.text: Five patients with idiopathic generalized epilepsies (IGE) treated with lamotrigine (LTG) experienced exacerbation or de novo appearance of myoclonic jerks (MJ). In three patients, LTG exacerbated MJ in a dose-dependent manner with early aggravation during titration. MJ disappeared when LTG dose was decreased by 25 to 50%. In two patients, LTG exacerbated MJ in a delayed but more severe manner, with myoclonic status that only ceased after LTG withdrawal.