标题：李明雪
个人简介
出生年月:1971.3
职称：副教授
党派：群众
教育和工作经历：
1991.9-1995.7河南大学化学系学士；
1995.7-1999.9河南省开封制药厂助理工程师；
1999.9-2002.7河南大学无机化学硕士
2002.9-2005.6南京大学无机化学博士
2002.7至今，河南大学讲师、副教授、硕士生导师、河南省教育厅学术技术带头人
学术研究
研究方向:目前主要从事金属配合物的设计和生物活性的基础研究。重点是设计一些具有生物活性的配体及其金属配合物，评价所合成的化合物的抗肿瘤活性及肿瘤治疗选择性的影响，初步分析配体的构效关系，分析金属的引入对配体生物活性的影响，进一步筛选出抗癌谱广，生物活性高、毒性小的金属配合物，为新药研究开发奠定基础。主持项目：1.         2006年河南省科技厅计划项目：茂铁基金属配合物的合成和性质研究（0611011900）；2006.1-2008.12；资助金额2万元；即将结项
2.         2007年度河南省教育厅自然科学研究项目：氨基硫脲金属配合物的合成和生物活性研究（2007150012）； 2007.1-2009.1；资助金额1万元；即将结项获奖：1.         2006年获省第九届自然科学优秀论文奖
1)        Octanuclear metallocyclic Ni4Fc4 compound: Synthesis, crystal structure, and electrochemical sensing for Mg2+
2)        Organosilyl derivatives of trivacant tungstophosphate of general formula alpha-A-[PW9O34(RSiO)3(RSi)]3 Synthesis and structure determination by X-ray crystallography  
2.2006年获河南省教育厅科技论文奖
1)        Octanuclear metallocyclic Ni4Fc4 compound: Synthesis, crystal structure, and electrochemical sensing for Mg2+
2)        Heterodimetallic Compounds Assembled from Ferrocene-containing Bisthiosemicarbazone Clips》  
3.  2008年度河南省教育厅科技论文奖
1)        Heterodimetallic Compounds Assembled from Ferrocene-containing Bisthiosemicarbazone Clips        
2)        Synthesis and crystal structure of a Mn(II) complex with thiosemicarbazone derivativeof pyridine-3-carbaldehyde showing unusual coordination modes of tridentate thiosemicarbazone                        
3)        Chiral aggregation and spontaneous resolution of thiosemicarbazone metal complexes
4)        Hydrothermal synthesis and crystal structure of a 1D fourfold-chain polyoxometalate-based complex[Cu(4,4ˊ-bipy)]2[SiW12O40{Cu(4,4ˊ -bipy)}4]∙(OH)2·H2O
4.   2008年荣获河南省科学技术进步奖叁等奖1项代表性论文：1.         Ming-xue Li, Ping Cai, Chun-ying Duan, Feng Lu, Jin Xie, Qing-jin Meng   Octanuclear Metallocyclic Ni4Fc4 Compound: Synthesis, Crystal Structure, and Electrochemical Sensing for Mg2+. Inorg. Chem. 2004, 43, 5174– 5176.
2.         Ming-xue Li, Yan Bai, Bing-guang Zhang, Chun-ying Duan,  Jian Xu, Qing-jin Meng，Heterometallic Compounds Assembled from Ferrocene-Containing Bisthiosemicarbazone Clips. Inorg. Chem. 2005，44，5459– 5466.
3.         Ming-xue Li, Qiao-zhen Sun, Chun-ying Duan etal. Chiral aggregation and spontaneous resolution of thiosemicarbazone metal complexes. J. Chem. Soc., Dalton Trans. 2006, 2572–2578．
4.         Ming-xue Li, Chun-ling Chen, Chun-sheng Ling, Jing Zhou, Bian-sheng Ji, Yan-juan Wu, Jing-yang Niu. Bioorganic & Medicinal Chemistry Letters, 2009，19，2704-2706.
5.         Ming-xue Li, Jing Zhou , Hong Zhao , Chun-Ling Chen, Jing-ping Wang. Iron(III) Complex of 2-Acetylpyrazine Thiosemicarbazone: Synthesis, Spectral Characterization, Structural Studies and Antitumoral Activity. Journal of Coordination Chemistry,2009,  , 6 2( 9) ， 1423 –1429.
6.         Ping Cai, Ming-xue Li, Chun-ying Duan, Feng Lu, Qing-jin Meng . Synthesis and Properties of the Geometrically Controlled Mixed-Valence Tetrahedral RuII2RuIII 2L6 Cluster. Eur.J. Inorg. Chem. 2005 ，2581– 2585.
7.         Ping Cai, Ming-xue Li, Chun-ying Duan, Feng Lu, Dong Guo and Qing-Jin Meng Syntheses, crystal structure and electrochemical properties of dinuclear ruthenium complexes containing saturated and unsaturated spacers New. J. Chem..2005，29，1011– 1016.
8.         Ming-xue Li, Juan Du, Jing-Ping Wang, Jing-Yang Niu Hydrothermal synthesis and crystal structure of a 1D fourfold-chain polyoxometalate-based complex [Cu(4,4′-bipy)]2[SiW12O40{Cu(4,4′-bipy)}4] · (OH)2 · H2O. Inorg.Chem.Commun. 2007,10(12) 1391– 13931.
9.         Ming-xue Li, Gui-ling Guo， Jing-yang Niu. A new organic-inorganic hybrid material constructed from Keggin polyanion and transition metal complexes: [Co(2,2'-bipy)3]1.5[SiWVWVI 11O40Co(2,2'-bipy)2(H2O)] · 0.5H2O J. Coord. Chem., 2008 , 61( 18)， 2896 – 2904
10.     Ming-xue Li, Gui-ling Guo， Jing-yang Niu, A new hybrid material constructed from octamolybdate anion and neutral dinuclear copper units. J. Coord. Chem. 2008 , 61( 23)， 3860 – 3868.
11.     Ming-xue Li, Jing Zhou , Hong Zhao , Chun-ling Chen, Jing-ping Wang. Iron(III) Complex of 2-Acetylpyrazine Thiosemicarbazone: Synthesis, Spectral Characterization, Structural Studies and Antitumoral Activity. J. Coord. Chem.,2009,  , 6 2( 9) ， 1423 –1429.
12.     Li Ming-Xue, Zhou Jing, Wang Jing-Ping，Wang, Zi-Liang. Synthesis and Crystal Structure of Mn（Ⅱ）Complex with Thiosemicarbazone Derivative of Pyridine-3-Carbaldehyde Showing Unusual Coordination Mode of Tridentate Thiosemicarbazone，Chinese J. Struct. Chem. 2006, 25, 1275– 1279.
13.     Ming-xue Li, Jing Zhou, Jing-ping Wang, Zi-liang Wang. Antitumor Metallothiosemicarbazonate:Synthesis, Crystal Structure, Spectra and Antitumor Studies of Co(III) Complex withThiosemicarbazone Derivative of 2-Benzoylpyridine. Chinese J. Struct. Chem. 2008, 27(3), 281– 286.
14.     Ming-xue Li, Jing Zhou, Zi Liang Wang, Jing-ping Wang. Synthesis, Crystal Structure and Antitumor Study of a Cobalt(II)Complex of the 2-Acetylpyrazine Thiosemicarbazone,Z. Naturforsch. 2008, 63b, 1 – 5.
15.     Ming-xue Li, Jing Zhou, Chun-ling Chen, Jing- ping Wang. Synthesis, Crystal Structure and Antitumor Study of a Zinc Complex of the 2-Benzoylpyridine Thiosemicarbazone Ligand Z. Naturforsch. 2008, 63b, 280 – 284.
16.     Ming-xue Li, Hong-yu Niu, Wei Wang, Jing-pingWang.  A Keggin-type Arsenotungstate Anion-supported Transition Metal Complex: Hydrothermal Synthesis and Characterization of [Fe(2,2_-bipy)3]1.5[AsWVI10WV 2O40Fe(2,2_-bipy)2(H2O)] · 0.25H2O Z. Naturforsch. 2008, 63b, 183 – 186.
17.     Ming-xue Li, Kai-hau Wang， Jing-yang Niu. Hydrothermal Synthesis and Crystal Structure of [Cu(en)2(H2O)]2{PW11.5Cu0.5O40[Cu(en)2]}·2H2O.Chinese J. Struct. Chem. 2008, 27(3), 340– 344.
18.     李明雪 ， 周静，王子梁，王敬平. 一维单链4-吡啶甲醛缩氨基硫脲合锌(Ⅱ)配位聚合物[Zn(HL)(CH3COO)2·H2O]n的合成、晶体结构及配体的新颖配位模式 应用化学，2008，25(1), 48– 52。