标题：卢大儒
基本信息
姓       名： 卢大儒  点击此处添加图片说明
任教专业： 理学-生物科学类
在职情况： 在
性       别： 男
所在院系： 生命科学学院
出生年月： 1965年7月
职称： 教授
个人简介
卢大儒  遗传学家。泰州海陵区人。1965年7月出生，1984年毕业于江苏省泰州中学，1988年毕业于复旦大学生物工程系，1996年获复旦大学博士学位。现为复旦大学生命科学学院遗传学研究所教授、博士生导师，复旦大学生命科学学院学术委员会委员、现代人类学教育部重点实验室副主任、复旦大学内分泌与糖尿病研究所副所长、复旦大学运动医学中心副主任，中国第六届全国科协委员、中国遗传学会常务理事、中国环境诱变剂学会理事，中国民族学会理事、上海市遗传学会秘书长。
个人其它信息
职务复旦大学生命科学学院副院长, 医学遗传学实验室主任(PI)
遗传工程国家重点实验室课题组长
现代人类学教育部重点实验室副主任
复旦大学内分泌与糖尿病研究所副所长
学术兼职中国遗传学会常务理事、中国环境诱变剂学会理事、中国优生优育协会常务理事
上海市遗传学会理事，秘书长、上海市人类学会副理事长，秘书长
分子细胞生物学报、人类学报、国际医学遗传学杂志、中国优生优育杂志和突变癌变畸变等杂志编委
主要研究方向
1 肿瘤分子流行病学研究，针对肺癌、脑胶质瘤等恶性肿瘤的发生发展和治疗进行大样本和多中心的肿瘤分子流行病学研究，筛选和鉴定遗传易感基因、治疗和预后相关基因，并进行深入的功能研究，对于恶性肿瘤的预防和个性化治疗具有重要意义。
2 糖尿病等代谢性疾病的分子遗传学和表观遗传学研究 围绕糖尿病开展胰岛素表达调控，胰腺发育分化，胰岛素抵抗机制及其干预和基因治疗等，在分子、细胞和动物水平进行遗传学和表观遗传学研究
3 基因检测和操作技术
熟悉并研究各种DNA分离纯化、DNA扩增、多种通量SNP检测、基因转染技术，开展基于纳米基因转染技术的基因治疗研究。
成就及荣誉
作为血友病B基因治疗研究探索者，卢大儒在他的导师指导下，先后研究制备了多种带有人FIX cDNA的反转录病毒、腺病毒和腺相关病毒，在小鼠、大鼠、兔和血友病B患者皮肤成纤维细胞、肌肉细胞、骨髓细胞和肝脏细胞中得到高效转移和表达。在国内率先建立了有关基因转移和治疗的安全检测系统，先后对4例血友病B患者进行了世界首次血友病B基因治疗的临床试验，取得了安全有效的结果。该研究是基因治疗中第一个被卫生部药政局批准进行临床试验的项目。
(1). 国家技术发明二等奖(1997)
(2)国家自然科学二等奖(2007)
(3). 国家教委科技进步一等奖(1995)
(4). 上海市科技进步一等奖(1997 )
(5)教育部提名自然科学一等奖(2002)
(6)上海市科技进步一等奖 (2005 )
(7)教育部提名自然科学一等奖(2007)
(8)国家级教学成果奖国家级二等奖(2005)
(9)上海市级教学成果一等奖(2005) 
并获得其他省部级科技奖励7项，其他个人获奖和荣誉包括：
第五届中国青年科技奖，霍英东教育基金会优秀青年教师一等奖， 首届全国优秀博士论文，国家教委"跨世纪"人才，教育部优秀青年教师，全国优秀教师，全国师德先进个人，国家"百千万人才工程" 国家级人才，上海市十佳优秀科技启明星等。
作为指导教师先后指导大学生获得全国"挑战杯"大学生课外科技作品竞最高奖4项，一等奖2项，二等奖1项。
个人论文和专著
论文发表情况:计发表各类论文近200篇，其中SCI论文近100篇，近年来，以通讯作者和并列通讯作者发表的SCI论文20余篇，包括Human Mutation、Pharmacogenetics and genomics、 Carcinogenesis、Cancer、lung cancer、Diabetologia、endocrinology等杂志 。主编《医学分子遗传学》、《基因治疗》，《生物芯时代》，《揭开生命奥秘》和《基因与疾病》, 另参与7本专著的编写。
近年代表性论文（* 通讯作者）1. Wu W, Liu H, Lei R, Chen D, Zhang S, Lv J, Wang Y, Fan W, Qian J, Jin G, Ma H, Miao R, Hu Z, Wang H, Jin L, Wei Q, Shen H, Huang W, Lu D*. Genetic variants in gtf2h1 and risk of lung cancer: A case-control analysis in a chinese population. Lung Cancer 2009; 63(2): 180-6.
2. Wang H, Jin G, Liu G, Qian J, Jin L, Wei Q, Shen H, Huang W, Lu D*. Genetic susceptibility of lung cancer associated with common variants in the 3' untranslated regions of the adenosine triphosphate-binding cassette b1 (abcb1) and abcc1 candidate transporter genes for carcinogen export. Cancer 2009; 115(3): 595-607.
3. Chen D, Tian T, Wang H, Liu H, Hu Z, Wang Y, Liu Y, Ma H, Fan W, Miao R, Sun W, Qian J, Jin L, Wei Q, Shen H, Huang W, Lu D*. Association of human aryl hydrocarbon receptor gene polymorphisms with risk of lung cancer among cigarette smokers in a chinese population. Pharmacogenet Genomics 2009; 19(1): 25-34.
4. Sun Z, Chen Z, Hou X, Li S, Zhu H, Qian J, Lu D*, Liu W. Locked nucleic acid pentamers as universal pcr primers for genomic DNA amplification. PLoS ONE 2008; 3(11): e3701.
5. Sun P, Qian J, Zhang ZB, Wan JX, Wu F, Jin XP, Fan WW, Lu D*, Zhao NQ, Christiani DC, Xia ZL. Polymorphisms in phase i and phase ii metabolism genes and risk of chronic benzene poisoning in a chinese occupational population. Carcinogenesis 2008; 29(12): 2325-9.
6. Shao M, Ma H, Wang Y, Xu L, Yuan J, Hu Z, Yang L, Wang F, Liu H, Qian J, Xun P, Chen W, Yuan W, Jing G, Chen F, Jin L, Wei Q, Wu T, Shen H, Huang W, Lu D*. Polymorphisms in excision repair cross-complementing group 4 (ercc4) and susceptibility to primary lung cancer in a chinese han population. Lung Cancer 2008; 60(3): 332-9.
7. Qian J, Jing J, Jin G, Wang H, Wang Y, Liu H, Li R, Fan W, An Y, Sun W, Ma H, Miao R, Hu Z, Jin L, Wei Q, Shen H, Huang W, Lu D*. Association between polymorphisms in the gsta4 gene and risk of lung cancer: A case-control study in a southeastern chinese population. Mol Carcinog 2008.
8. Liu Y, Zhou K, Zhang H, Shugart YY, Chen L, Xu Z, Zhong Y, Liu H, Jin L, Wei Q, Huang F, Lu D*, Zhou L. Polymorphisms of lig4 and xrcc4 involved in the nhej pathway interact to modify risk of glioma. Hum Mutat 2008; 29(3): 381-9.
9. Liu H, Jin G, Wang H, Wu W, Liu Y, Qian J, Fan W, Ma H, Miao R, Hu Z, Sun W, Wang Y, Jin L, Wei Q, Shen H, Huang W, Lu D*. Association of polymorphisms in one-carbon metabolizing genes and lung cancer risk: A case-control study in chinese population. Lung Cancer 2008; 61(1): 21-9.
10. Liu H, Jin G, Wang H, Wu W, Liu Y, Qian J, Fan W, Ma H, Miao R, Hu Z, Sun W, Wang Y, Jin L, Wei Q, Shen H, Huang W, Lu D*. Methyl-cpg binding domain 1 gene polymorphisms and lung cancer risk in a chinese population. Biomarkers 2008; 13(6): 607-17.
11. Jiang MH, Fei J, Lan MS, Lu ZP, Liu M, Fan WW, Gao X, Lu D*. Hypermethylation of hepatic gck promoter in ageing rats contributes to diabetogenic potential. Diabetologia 2008; 51(8): 1525-33.
12. Cheng Q, Cheng H, Wang L, Zhong Y, Lu D*. A preliminary genetic distinctness of four coilia fishes (clupeiformes: Engraulidae) inferred from mitochondrial DNA sequences. Genetika 2008; 44(3): 395-400.
13. Chen D, Jin G, Wang Y, Wang H, Liu H, Liu Y, Fan W, Ma H, Miao R, Hu Z, Sun W, Qian J, Jin L, Wei Q, Shen H, Huang W, Lu D*. Genetic variants in peroxisome proliferator-activated receptor-gamma gene are associated with risk of lung cancer in a chinese population. Carcinogenesis 2008; 29(2): 342-50.
14. An Y, Jin G, Wang H, Wang Y, Liu H, Li R, Qian J, Sun W, Ma H, Miao R, Hu Z, Jin L, Wei Q, Shen H, Huang W, Lu D*. Polymorphisms in hmlh1 and risk of early-onset lung cancer in a southeast chinese population. Lung Cancer 2008; 59(2): 164-70.
15. Xue FL, Chen JY, Guo J, Wang CC, Yang WL, Wang PN, Lu D*. Enhancement of intracellular delivery of cdte quantum dots (qds) to living cells by tat conjugation. J Fluoresc 2007; 17(2): 149-54.
16. Qian X, Lu Z, Tan M, Liu H, Lu D*. A meta-analysis of association between c677t polymorphism in the methylenetetrahydrofolate reductase gene and hypertension. Eur J Hum Genet 2007; 15(12): 1239-45.
17. Ma H, Xu L, Yuan J, Shao M, Hu Z, Wang F, Wang Y, Yuan W, Qian J, Wang Y, Xun P, Liu H, Chen W, Yang L, Jin G, Huo X, Chen F, Shugart YY, Jin L, Wei Q, Wu T, Shen H, Huang W, Lu D*. Tagging single nucleotide polymorphisms in excision repair cross-complementing group 1 (ercc1) and risk of primary lung cancer in a chinese population. Pharmacogenet Genomics 2007; 17(6): 417-23.
18. Lu J, Li G, Lan MS, Zhang S, Fan W, Wang H, Lu D*. Pax4 paired domain mediates direct protein transduction into mammalian cells. Endocrinology 2007; 148(11): 5558-65.
19. Liu Y, Zhang H, Zhou K, Chen L, Xu Z, Zhong Y, Liu H, Li R, Shugart YY, Wei Q, Jin L, Huang F, Lu D*, Zhou L. Tagging snps in non-homologous end-joining pathway genes and risk of glioma. Carcinogenesis 2007; 28(9): 1906-13.
20. Li Y, Jin G, Wang H, Liu H, Qian J, Gu S, Ma H, Miao R, Hu Z, Sun W, Wang Y, Jin L, Wei Q, Shen H, Huang W, Lu D*. Polymorphisms of cak genes and risk for lung cancer: A case-control study in chinese population. Lung Cancer 2007; 58(2): 171-83.
21. Huang Y, Chen J, Li G, Cheng TY, Jiang MH, Zhang SY, Lu J, Yan S, Fan WW, Lu D*. Reversal of hyperglycemia by protein transduction of neurod in vivo. Acta Pharmacol Sin 2007; 28(8): 1181-8.
22. Guo X, Cheng L, Liu Y, Fan W, Lu D*. Cloning, expression, and functional characterization of zebrafish mist1. Biochem Biophys Res Commun 2007; 359(1): 20-6.
23. Cheng L, Chong M, Fan W, Guo X, Zhang W, Yang X, Liu F, Gui Y, Lu D*. Molecular cloning, characterization, and developmental expression of foxp1 in zebrafish. Dev Genes Evol 2007; 217(10): 699-707.
24. Bai Y, Xu L, Yang X, Hu Z, Yuan J, Wang F, Shao M, Yuan W, Qian J, Ma H, Wang Y, Liu H, Chen W, Yang L, Jing G, Huo X, Chen F, Liu Y, Jin L, Wei Q, Huang W, Shen H, Lu D*, Wu T. Sequence variations in DNA repair gene xpc is associated with lung cancer risk in a chinese population: A case-control study. BMC Cancer 2007; 7: 81.
25. Xin X, Xiao J, Luan X, Zhou Y, Lu D*, Wei D, Yang S. Association study of six activity snps in adrenal steroid hormone metabolism and ibm related genes with precocious puberty in chinese girls. Neuro Endocrinol Lett 2006; 27(1-2): 219-24.
26. Lin GF, Du H, Chen JG, Lu HC, Guo WC, Meng H, Zhang TB, Zhang XJ, Lu D*, Golka K, Shen JH. Arsenic-related skin lesions and glutathione s-transferase p1 a1578g (ile105val) polymorphism in two ethnic clans exposed to indoor combustion of high arsenic coal in one village. Pharmacogenet Genomics 2006; 16(12): 863-71.
27. Jiang Z, Li X, Hu J, Zhou W, Jiang Y, Li G, Lu D*. Promoter hypermethylation-mediated down-regulation of lats1 and lats2 in human astrocytoma. Neurosci Res 2006; 56(4): 450-8.
28. Jiang Z, Hu J, Li X, Jiang Y, Zhou W, Lu D*. Expression analyses of 27 DNA repair genes in astrocytoma by taqman low-density array. Neurosci Lett 2006; 409(2): 112-7.
29. Hu Z, Shao M, Chen Y, Zhou J, Qian J, Xu L, Ma H, Wang X, Xu Y, Lu D*, Shen H. Allele 2 of the interleukin-1 receptor antagonist gene (il1rn*2) is associated with a decreased risk of primary lung cancer. Cancer Lett 2006; 236(2): 269-75.
30. Cheng L, Guo XF, Yang XY, Chong M, Cheng J, Li G, Gui YH, Lu D*. Delta-sarcoglycan is necessary for early heart and muscle development in zebrafish. Biochem Biophys Res Commun 2006; 344(4): 1290-9.
31. Chen J, Li G, Lu J, Chen L, Huang Y, Wu H, Zhang J, Lu D*. A novel type of ptd, common helix-loop-helix motif, could efficiently mediate protein transduction into mammalian cells. Biochem Biophys Res Commun 2006; 347(4): 931-40.
32. Chen J, Chen L, Li G, Cheng L, Huang Y, Zhang JX, Fan WW, Lu D*. Amino acid 1-209 is essential for pdx-1-mediated repression of human cmv ie promoter activity. Acta Pharmacol Sin 2006; 27(11): 1495-503.
33. Fu W, Wang Y, Lu D*. Multifractal analysis of genomic sequences cgr images. Conf Proc IEEE Eng Med Biol Soc 2005; 5: 4783-6.
34. Cheng QQ, Lu D*. Pcr-rflp analysis of cytochrome b gene does not support coilia ectenes taihuensis being a subspecies of coilia ectenes. J Genet 2005; 84(3): 307-10.
35. Wen B, Li H, Lu D, Song X, Zhang F, He Y, Li F, Gao Y, Mao X, Zhang L, Qian J, Tan J, Jin J, Huang W, Deka R, Su B, Chakraborty R, Jin L. Genetic evidence supports demic diffusion of han culture. Nature 2004; 431(7006): 302-5.
36. Chen J, Yang WL, Li G, Qian J, Xue JL, Fu SK, Lu D*. Transfection of mepo gene to intestinal epithelium in vivo mediated by oral delivery of chitosan-DNA nanoparticles. World J Gastroenterol 2004; 10(1): 112-6.
37. Yang XY, Yao JH, Cheng L, Wei DW, Xue JL, Lu D*. Molecular cloning and expression of a smooth muscle-specific gene sm22alpha in zebrafish. Biochem Biophys Res Commun 2003; 312(3): 741-6.
38. Ke Y, Su B, Song X, Lu D, Chen L, Li H, Qi C, Marzuki S, Deka R, Underhill P, Xiao C, Shriver M, Lell J, Wallace D, Wells RS, Seielstad M, Oefner P, Zhu D, Jin J, Huang W, Chakraborty R, Chen Z, Jin L. African origin of modern humans in east asia: A tale of 12,000 y chromosomes. Science 2001; 292(5519): 1151-3.