标题：钱永常
个人简介
钱永常，博士，浙江农林大学特聘教授、浙江省“千人计划”创业人才、教授级高级工程师、浙江省特聘专家、中国医药生物技术协会理事、杭州市萧山海创会副会长。
科研兴趣
神经元细胞和星形胶质细胞在大脑功能中的相互作用
神经退行性疾病中蛋白质的质控
蛋白质聚合和分子神经毒理学
生物技术在生物制药和环境治理中的应用
学习经历
1993-1998, 美国德州A&M大学生化与分子营养学博士后
1991-1993, 美国加州大学戴维斯分校植物生理与生化博士后
1985-1990, 中国科学院上海分院获植物生理学博士学位
1981-1985, 中国上海复旦大学获生物学学士学位
科研经历
1999-2009, 美国德州A&M大学神经科学与毒理学计划的实验室主任, 研究助理教授，副教授.
1993-1998, 美国德州A&M大学生化与生物物理系博士后.
1991-1993, 美国加州大学戴维斯分校博士后.
1985-1990, 中国科学院上海分院研究生研究助理.
1984-1985, 中国上海复旦大学生物系研究助理.
科研成果
1995年，钱永常博士在国际上第一次确定了在神经退行性疾病中起极其重要作用的大鼠铜泵Atp7a基因序列，直接被美国国家生物技术信息中心（NCBI）收录
2000-2005年间，国际上第一次确认对儿童的智力发育有严重危害的重金属铅专一性攻击铜泵Atp7a，在分子水平上对重金属铅的神经毒性研究是一个极其重要的发现，相关工作被发表在毒理学和神经毒理学的国际顶级杂志上
2008年，钱永常博士研究组在国际上第一次报道，重金属铅可以直接攻击淋巴细胞中参与免疫球蛋白分泌的伴侣分子，为重金属铅的免疫毒性研究提出了一个全新的分子机理，工作发表在中国预防医学的权威杂志上
2009年，钱永常博士国际上首次报道目前在临床上广泛使用的抗惊厥和癫痫药，2-丙基戊酸钠（valproate），严重影响人类神经细胞突触的生长，相关工作发表在著名的《大脑研究》杂志上
2010年，钱永常博士带领的杭州纽龙生物科技有限公司的技术团队，研发出一种生物活性蛋白/多肽的新型纯化技术，目前正在申请技术专利，同时相应的专利产品即将面市。生物活性蛋白/多肽的纯化技术是生物制药领域的关键技术，是此领域的难点和热点，纽龙生物在此领域的技术突破，为神经活性多肽的微生物工程生产提供极其重要的保证.
受邀审稿人的科学期刊
中国生化与生物物理学报(Acta Biochimica et Biophysica Sinica)
毒理学的化学研究(Chemical Research in Toxicology)
细胞生物化学杂志(Journal of Cellular Biochemistry）
神经化学杂志(Journal of Neurochemistry)
毒理学杂志(Journal of Toxicology)
毒理学与环境健康杂志(Journal of Toxicology and Environmental Health)
环境健康展望(Environmental Health Perspectives)
神经毒性研究(Neurotoxicity Research)
神经毒理学(Neurotoxicology)
药物学研究(Pharmacological Research)
整体环境的科学(Science of the Total Environment)
体外毒理学(Toxicology in Vitro)
专业机构会员
美国毒理学会(Society of Toxicology)
美国神经化学学会(American Society of Neurochemistry)
获奖与科研资助
1999, 优秀博士后奖Gulf Coast Chapter Society of Toxicology Annual Meeting, Houston, Texas
2000-2001, 美国德州A&M大学CVM优先计划, "Lead and Copper Competitively Bind to HMB of ATP7A and GRP78" (项目主任, 25%贡献), 资助金额9,780美元
2000-2005, 美国国立环境与健康研究所项目NIEHS P42 ES04917, “Stress Gene Induction in Mammalian Cells”(项目副主任, 40%贡献), 资助金额840,000美元.
2005-2006, 美国国防部项目DOD-CDMRP Concept Award W81XWH-05-1-0163, "The Function of Neurofibromin in Astrocytes" (项目副主任, 40%贡献), 资助金额100,000美元.
2008-2008, 美国德州A&M大学基金, “The Function of Astrocytes in Brain Glucose Utilization”(项目主任, 50% 贡献), 资助金额8,000美元.
2009-2010, 美国国立环境与健康研究所项目NIH-NIEHS R21, “Long-Term Monitoring of Dementia-Related Markers in Lead Workers from China”(项目主任, 30% 贡献), 资助金额515,000美元.
发表的文章
1.钱永常, Ying Zheng, Evelyn Tiffany-Castiglioni. Hspa5 Depletion Predisposes Glioma Cells to Curcumin Treatment. In preparation.
2.钱永常, Ying Zheng, Bingchao Meng2, Robert Taylor, Evelyn Tiffany-CastiglioniHSPA5 Specifically Forms Complexes with Copper. In preparation to Neurochemical Research.
3. Tiffany-Castiglioni, E., 钱永常. ER Chaperone-Metal Interactions: Links to Protein Folding Disorders. Neurotoxicology In press, 2012.
4. 钱永常, Zheng, Y., Taylor, R., Tiffany-Castiglioni, E. Involvement of the Molecular Chaperone HSPA5 in Copper Homeostasis in Astrocytes. Brain Research 1447: 9-19, 2012.
5. Tiffany-Castiglioni, E., Hong, S., 钱永常. Copper Handling by Astrocytes: Insights into Neurodegenerative Diseases. International Journal of Developmental Neuroscience 29: 811-818, 2011.
6. Barhoumi, R., 钱永常, Burghardt, R., Tiffany-Castiglioni, E. Image Analysis of Ca2+ Signals as a Basis for Neurotoxicity Assays: Promises and Challenges. Neurotoxicology and Teratology. 32: 16-24, 2010.
7. 钱永常, Zheng, Y, Tiffany-Castiglioni, E. Valproate Reversibly Reduces Neurite Outgrowth by Human SY5Y Neuroblastoma Cells. Brain Research 1302:21-33, 2009.
8. Wang, LJ, Zheng, Y, 钱永常.断乳仔鼠器官中铅分布和78000糖调蛋白的变化. 《中华预防医学杂志》第42卷，第10期：731-734页, 2008(abstract in English).
9. White, LD., Cory-Slechta, DA., Gilbert, ME., Tiffany-Castiglioni, E., Zawia, NH., Virgolini, M., Rossi-George, A., Lasley, SM., 钱永常, Basha, MR. New and Evolving Concepts in the Neurotoxicology of Lead. Toxicology and Applied Pharmacology225: 1-27, 2007.
10.钱永常, Zheng, Y, Weber, D, Tiffany-Castiglioni, E. A 78kD Glucose-Regulated Protein Is Involved In Decrease Of Interleukin-6 Secretion By Lead Treatment From Astrocytes. American Journal of Physiology-Cell Physiology293: C897-C905, 2007.
11. Wang, L. J., Zheng, Y., 钱永常. 低水平铅暴露对仔鼠白细胞78kd糖调蛋白表达的影响. 《国际医药卫生导报》第13卷，第12期：8-12页，2007(abstract in English).
12. Falahatpisheh, H., Nanez, A., Montoya-Durago, D., 钱永常, Tiffany-Castiglioni, E., Ramos, KS. Activation Profiles of HSPA5 During the Glomerular Mesangial Cell Stress Response to Chemical Injury. Cell Stress & Chaperones 12: 209-218, 2007.
13. Barhoumi, R., Burghardt, R., 钱永常, Tiffany-Castiglioni, E. Effects of propofol on intracellular Ca2+ homeostasis in human astrocytoma cells. Brain Research 1145: 11-18, 2007.
14.钱永常, Venkatraj, J., Barhoumi, R., Pal, R., Datta, A., Wild, J. R., Tiffany-Castiglioni, E. Comparative non-cholinergic neurotoxic effects of paraoxon and diisopropyl fluorophosphate (DFP) human neuroblastoma and astrocytoma cell lines. Toxicology and Applied Pharmacology219: 162-171, 2007.
15. Tiffany-Castiglioni, E., Hong, S., 钱永常, Tang, Y., Donnelly, K.C. COMMENTARY: In Vitro Models for Assessing Neurotoxicity of Mixtures. Neurotoxicology 27: 835-839, 2006.
16. Tiffany-Castiglioni, E., Venkatraj, J.S., 钱永常. Genetic polymorphisms and mechanisms of neurotoxicity: overview. Neurotoxicology 26: 641-649, 2005.
17.钱永常, Zheng, Y., Ramos, K.S., Tiffany-Castiglioni, E. The Involvement of Copper Transporter in Lead-induced Oxidative Stress in Astroglia. Neurochemical Research 30: 429-438, 2005.
18.钱永常, Zheng, Y., Abraham, L., Ramos, K.S., Tiffany-Castiglioni, E. Differential Profiles of Copper-induced ROS Generation in Human Neuroblastoma and Astrocytoma Cells. Molecular Brain Research 134: 323-332, 2005.
19.钱永常, Zheng, Y., Ramos, K.S., Tiffany-Castiglioni, E. GRP78 compartmentalized redistribution in pb-treated glia: role of grp78 in lead-induced oxidative stress. Neurotoxicology26: 267-275, 2005.
20. Donnelly, K.C., Lingenfelter, R., Cizmas, L., Falahatpisheh, M.H., 钱永常, Tang, Y., Garcia, S., Ramos, K.S., Tiffany-Castiglioni, E., Mumtaz, M.M. Toxicity assessment of complex mixtures remains a goal. Environmental Toxicology and Pharmacology 18: 135-141, 2004
21.陈益民，孙文浩，钱永常，李梨，蔡捷，董建国。怀念我们的老师－余叔文先生。植物生理学通讯，40卷3期，397-398页，2004. (in Chinese)
22.钱永常, Tiffany-Castiglioni, E., Lead-induced endoplasmic reticulum (ER) stress responses in the nervous system. Neurochemical Research 28: 153-162, 2003
23. Tiffany-Castiglioni, E.,钱永常, Astroglia as metal depots: molecular mechanisms for metal accumulation, storage and release. Neurotoxicology 55: 1-16, 2001
24.钱永常, Falahatpisheh, M.H., Zheng, Y., Ramos, K.S., Tiffany-Castiglioni, E., Induction of 78 kD Glucose-Regulated Protein (GRP78) Expression and Redox-Regulated Transcription Factor Activity by Lead and Mercury in C6 Rat Glioma Cells. Neurotoxicity Research, 3:581-589, 2001
25.钱永常, Harris, E.D., Zheng, Y., Tiffany-Castiglioni, E., Lead (Pb) targets GRP78, a molecular chaperone, in C6 rat glioma cells. Toxicol. Appl. Pharmacol. 163: 260-266, 2000
26.钱永常, Mikeska, G., Harris, E.D., Bratton, G.R., Tiffany-Castiglioni, E., Effect of lead exposure and accumulation on copper homeostasis in cultured C6 rat glioma cells. Toxicol. Appl. Pharmacol. 158:41-49, 1999
27. Harris, E.D., Reddy M.C.M., 钱永常, Tiffany-Castiglioni, E., Majumdar, S., Nelson, J. Multiple forms of the Menkes Cu-ATPase. Adv. Exp. Med. Biol. 448:39-51, 1999
28. Harris, E.D., 钱永常, Reddy, M.C., Genes regulating copper metabolism. Mol. Cell. Biochem. 188: 57-62, 1998
29.钱永常, Tiffany-Castiglioni, E., Welsh, J., Harris, ED., Copper efflux from murine microvascular cells requires expression of the Menkes disease Cu-ATPase. J. Nutr.128: 1276-1282,1998
30.钱永常, Tiffany-Castiglioni, E., Harris, ED., Sequence of a Menkes-type Cu-transporting ATPase from rat C6 glioma cells: comparison of the rat protein with other mammalian Cu-transporting ATPases. Mol. Cell. Biochem. 181:49-61, 1998
31. Harris, ED., 钱永常, Tiffany-Castiglioni, E., Lacy, A., Reddy, MCM., A functional analysis of copper homeostasis in various cell lines: A new perspective on internal copper transport. Am. J. Clin. Nutr. 67:988s-995s, 1998(suppl)
32.钱永常, Tiffany-Castiglioni, E., Harris, ED., A Menkes P-type ATPase involved in Cu homeostasis in the central nervous system of the rat. Mol. Brain Res. 48: 60-66, 1997
33.钱永常, Tiffany-Castiglioni, E., Harris, E.D. Functional Analysis of A Genetic Defect of Copper Transport (Menkes Disease) in Different Cell lines. Am. J. Physiol.: 271(Cell Physiol. 40): C378-C384, 1996
34.钱永常, Majumdar, S., Reddy, M.C.M., and Harris, E.D. Coincident Expression of Menkes Gene with Copper Efflux in Human Placental Cells. Am. J. Physiol.: 270(Cell Physiol. 39): C1880-1884, 1996
35.钱永常, Tiffany-Castiglioni, E., Harris, E.D. Copper transport and kinetics in cultured C6 rat glioma cells. Am. J. Physiol., 269 (Cell Physiol. 38): C892-C898, 1995
36.钱永常, Nguyen, T., Murphy, T.M. Effect of washing on the plasma membrane and on stress reactions of cultured rose cells. Plant Cell, Tissue, and Organ Culture, 35: 245-252, 1993
37.钱永常& Murphy, T.M. Regulation of plasma membrane ATPase by glutathione in rose cells irradiated with UV-C. Plant Physiol. Biochem., 31(6): 901-909, 1993
38.钱永常,余叔文. 二氧化硫对不同作物中昆虫必需安基酸的影响. 环境科学学报, 12(3):325-332, 1992 （英文摘要）
39.钱永常,余叔文. 大豆苗在适应二氧化硫的过程中表达一个15kDa的蛋白质. 植物生理学学报, 17(4):365-372, 1991 （英文摘要）
40.钱永常,余叔文. 大豆苗对二氧化硫的适应性反应. 植物生理学学报 17(3): 232-238, 1991 （英文摘要）
41.钱永常,余叔文. 二氧化硫对植物的氧化作用和植物的抗氧化作用. 植物生理学通讯. 27(5): 326-331, 1991 （英文摘要）
42.钱永常& Yu, S-W. Change of protein pattern in Glycine max fumigated with SO2. 植物生理学学报, 16(1): 81-85, 1990
43.钱永常,余叔文. 植物中的逆境蛋白. 植物生理学通讯 25(5):5-11, 1989 （英文摘要）[1]