标题：赵存友
赵存友 （Zhao Cunyou）
南方医科大学基础医学院医学遗传学教授。研究方向为人类遗传疾病的分子遗传学、表观遗传学及基因诊断技术。2008年获香港科技大学生物工程学专业博士学位。2009-2011年在香港科技大学应用基因组中心从事博士后研究，并被聘为副研究员（Research Associate)、研究助理教授(Research Assistant Professor)。2011年受聘“南方医科大学引进人才”教授岗位至今。2003年起从事伽玛氨基丁酸A型受体（GABAA receptor）beta 2亚基基因（GABRB2）的DNA变异、RNA表达、DNA甲基化及羟甲基化异常参与精神分裂症致病机制的研究，以及基于DNA甲基化的分子诊断技术的研发。近年来在Molecular Psychiatry，Epigenetics，PLoS ONE, Schizophrenia Research等专业期刊发表SCI论文19篇（累计IF=103），其中第一作者或通讯作者文章7篇（累计IF=39，单篇最高IF=15.4）。主持广东省自然科学基金2项、广东省教育厅引进人才专项基金1项，南方医科大学引进人才专项基金1项。曾获2010年教育部高等学校科学研究优秀成果奖-自然科学类2等奖（第3完成人）(Email:zhaocunyou AT gmail dot com).
Professor Cunyou Zhao is Professor of Department of Medical Genetics in Southern Medical University. He obtained his Ph.D. in Bioengineering from the Hong Kong University and Technology (HKUST) in 2008. He then worked at the Division of Life Science in HKUST as an postdoctoral fellow. Professor Zhao was appointed as Research Assistant Professor at Applied Genomics Center in HKUST in 2009. He joined Southern Medical University in 2011 as a full professor. The research interests of Professor Zhao focus on genetic variations, RNA expression and DNA methylation & hydroxymethylation of the GABA(A) receptor beta(2) subunit gene (GABRB2) involving in the etiology of schizophrenia, a debilitating mental illness that affects 1% of the world’s population. He published several papers in the journals of Molecular Psychiatry, Epigenetics, PLoS ONE, and Schizophrenia Research et al.(Email:zhaocunyou AT gmail dot com).
教育背景：
2004.9-2008.1             香港科技大学 生物工程学专业                       博士
1997.9-2000.6              沈阳农业大学 生物化学与分子生物学专业      硕士 
1993.9-1997.6              黑龙江八一农垦大学 农学专业                       学士
工作经历：
2011.10 ~                      南方医科大学基础医学院            教授
2009.6-2011.9              香港科技大学应用基因组中心      副研究员、研究助理教授、
2008.4-2009.6              香港科技大学生物化学系             博士后
2003.7-2004.8              香港科技大学生物化学系             助理研究员 
2000.7-2003.6             中国科学院院微生物所                  助理研究员 
荣誉和奖励：
2010年度 高等学校科学研究优秀成果奖-自然科学二等奖（第3完成人）
科研项目：
1. 主持在研，广东省高等学校人才引进专项（2050205）：精神分裂症易感基因GABRB2的调控机制研究及基于DNA甲基化分子诊断技术的探讨，2012-2014。
2. 主持在研，南方医科大学高层次人才引进专项（B1000430）：精神分裂症易感基因功能研究，2011-2013。
3. 主持在研，广东省自然科学基金自由申请项目(10179942783X000002)：精神分裂症候选基因GABRB2表达调控机制的研究，2010-2012。
4. 主持完成，广东省自然科学基金博士启动项目（9479942783X001963）：GABRB2基因的甲基化修饰与RNA表达的细胞调控模型，2010-2011。
发表文章：
2011-2012年度：1. Zhao C and Xue H. A simple method for high-throughput quantification of genome-wide DNA methylation by fluorescence polarization. Epigenetics 2012: 7(4);doi: epi.7.4.19376 (IF: 4.633)
2. Zhao C, Wang F, Frank W. Pun, Mei L, Ren L, Yu Z, Ng SK, Chen J, Tsang SY and Xue H. Epigenetic regulationson GABRB2 isoform expression: developmental variations and disruptions in psychotic disorders.Schizophrenia Research 2012:134:260-266; doi: 10.1016/j.schres.2011.11.029 (IF: 4.374)
3. Pun FW, Zhao C, Lo WS, Ng SK, Tsang SY, Nimgaonkar V, Chung WS, Ungvari GS and Xue H. Imprinting in the schizophrenia risk gene coding for GABA(A) receptor beta2 subunit. Molecular Psychiatry 2011:16(5):557-568;doi:10.1038/mp.2010.47 (IF: 15.470)
4. Fang S, Li J, Cheng X, Zhao C, Wang T, Lv X, Wang X, Wu C, Zhang R, Chen J, Xue H, Yu M. Simultaneous detection of influenza virus type B and influenza A virus subtypes H1N1, H3N2, and H5N1 using multiplex real-time RT-PCR. Applied Microbiology Biotechnology 2011:90(4):1463-70; doi: 10.1007/ s00253-011-3192-8 (IF: 3.280)
5. Ren L, Chan WM, Wang F, Xu Z, Zhao C, Mat WK, Chai YW, Wong TF, Tsang SY and Xue H. Effects of flavone 6-subsitutions on GABA(A) receptor efficacy. European Journal of Pharmacology 2011:670:(1):121-129; doi:10.1016/ j.ejphar.2011.08.021 (IF:2.737)
6. Mei L, Ding X, Tsang SY, FW. Pun, Ng SK, Zhao C, Li D, Wan W, Zhang L and Xue1 H. AluScan: a method for genome-wide scanning of sequence variations in the human genome. BMC Genomics2011:12:564; doi:10.1186/1471-2164-12-564 (IF:4.210) 
7. Zhang N, Fang S, Wang T, Li J, Cheng X, Zhao C, Wang X, Lv X, Wu C, Zhang R, Cheng J, Xue H, and Lu Z. Applicability of a sensitive duplex real-time PCR assay for identifying B/Yamagata and B/Victoria lineages of influenza virus from clinical specimens.Applied Microbiology Biotechnology 2011; doi:10.1007/s00253-011-3710-8(IF: 3.280)
8. 李鑫，贾爱华，任玉波，许士明，田秀丽，赵存友，李学元。哺乳动物雷帕霉素靶蛋白和存活蛋白在人脑角质瘤中表达的研究。中华临床医师杂志 2011:5(5):65-682009-2010年度：1. Ng SK, Lo WS, Pun FW, Zhao C, Yu Z, Chen J, Tong KL, Xu Z，Tsang SY, Yang Q, Yu W, Stober G, Harano M, and Xue H. A Recombination Hotspot in a Schizophrenia-Associated Region ofGABRB2. PLoS ONE 2010:5(3):e9547; doi:10.1371/journal.pone.0009547 (IF: 4.411)
2. Ren L, Wang F, Xu Z, Chan WM, Zhao C and Xue H. GABA(A) receptor subtype selectivity underlying anxiolytic effect of 6-hydroxyflavone. Biochemical Pharmacology 2010:79(9):1337-44; doi: DOI: 10.1016/j.bcp.2009.12.024 (IF: 4.889)
3. Zhao C, Xu Z, Wang F, Chen J, Ng SK, Wong PK, Yu Z, Pun FW, Ren L, Lo WS, Tsang SY, Xue H. Alternative-splicing in the Exon-10 region of GABA(A) receptor beta2 subunit gene: relationships between novel isoforms and psychotic disorders. PLoS ONE 2009: 4(9):e6977; doi:10.1371/journal.pone.0006977 (IF: 4.411)
4. Chen J*, Tsang SY*, Zhao C*, Pun FW, Yu Z, M L, Lo WS, Fang S, Liu H,Stober G, Xue H. GABRB2 in schizophrenia and bipolar disorder: disease association, expression and clinical correlations. Biochemical Society Transactions 2009：37:1415-18; doi:10.1042/BST0371415 (并列第一;IF: 3.989)
5. C.Y. Zhao, Z. Xu, F. Wang, Z. Yu, W.S. Lo, J. Chen, F.W. Pun, S.Y. Tsang, H. Xue. P03-219 An alternative-splicing hot-spot in GABRB2: Novel splicing variants associated with major psychotic disorders. European Psychiatry. 2009: 2(S1):S1218; doi:10.1016/S0924-9338(09)71451-8 (IF: 3.365)2007-2008年度：1. Lo WS, Xu Z, Yu Z, Pun FW, Ng SK, Chen J, Tong KL, Zhao C, Xu X, Tsang SY, Harano M, Stober G, Nimgaonkar VL, Xue H. Positive selection within the Schizophrenia-associated GABA(A) receptor beta2 gene. PLoS ONE2007: 2(5): e462; doi:10.1371/journal.pone.0000462 (IF: 4.411)
2. Lo WS, Harano M, Gawlik M, Yu Z, Chen J, Pun FW, Tong KL, Zhao C, Ng SK, Tsang SY, Uchimura N, Stober G, Xue H. GABRB2 Association with Schizophrenia: Commonalities and Differences Between Ethnic Groups and Clinical Subtypes. Biological Psychiatry 2007: 61(5): 653-660; doi:10.1016/j.biopsych.2006.05.003 (IF: 8.674)2005-2006年度：1. Zhao C, Xu Z, Chen J, Yu Z, Tong KL, Lo WS, Pun FW, Ng SK, Tsang SY, Xue H. Two isoforms ofGABA(A) receptor beta2 subunit with different electrophysiological properties: differential expression and genotypical correlations in schizophrenia. Molecular Psychiatry 2006: 11(12): 1092-1105; doi:10.1038/sjmp4001899 (IF: 15.470)
2. Lo WS, Zhao C, Xu Z, Chen J, Yu Z, Pun FW, Tong KL, Ng SK, Tsang SY, Xue H. Cross-population validation of schizophreniaassociation and functional analysis on mRNA expression and electrophysiological properties of two isoforms of GABRB2. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics 2006: 141B (7): 800-801 (IF:4.156)
3. Xue H, Lo WS, Harano M, Gawlik M, Yu Z, Chen J, Pun FW, Tong KL, Zhao C, Ng SK, Tsang SY, Uchimura N, Stober G. Association of SNPs and haplotypes in GABRB2 with schizophrenia in Japanese and German-Caucasians. FASEB J 2006: 20(5): A909 (IF: 6.515)2001-2004年度：1. Zhao C, Chen Y, Park J, Kim JB, Tang H. Tat-dependent repression of human immunodeficiency virus type 1 long terminal repeat promoter activity by fusion of cellular transcription factors. Biochemical and Biophysical Research Communications 2004: 322(2): 614-22; doi:10.1016/j.bbrc.2004.07.165 (2004.9发表; IF:2.720)
2. 赵存友，袁正强，秦洪敏，田颖川。转双抗虫基因烟草的研究。生物工程学报2001:17(3):273-277 
3. Yuan ZQ, Zhao CY, Zhou Y, Tian YC. Aphid-resistant transgenic tobacco plants expressing modified gna gene. ACTA BOTANICA SINICA 2001: 43(6): 592-597(IF: 1.603)