标题：董旻岳
个人简介
董旻岳 ，男，1964年4月出生，浙江大学医学部博士生导师，浙江大学医学部妇产科医院主任医师。  　　从事妇产科学临床和基础研究，主要研究方向为妊娠生理、妊娠免疫耐受机制以及子痫前期和妊娠期肝内胆汁淤积症的病因学研究，同时对TORCH感染、产前诊断和优生优育也有一定关注。已经主持或主要参与省、厅课题十余项，发表学术论文五十余篇，其中SCI收录论文10篇，获浙江省科技进步奖优秀奖和浙江省医药科技进步奖二等奖各一项。
1985年毕业于浙江医科大学医学系，2000年－2001年在美国伊利诺依大学芝加哥分校（UIC）医学院从事生殖生理学博士后研究。研究领域为生殖医学和围产医学，主要研究方向为妊娠免疫耐受机制、生殖和妊娠相关疾病的免疫学病因与发病机制，近年特别关注滋养细胞对T淋巴细胞的调节作用与机制以及子痫前期的免疫学机理。主持、承担国家自然科学基金、973项目子课题等课题多项。领衔的课题组在国内外首先报道了母体界面细胞因子Th1/Th2平衡、IL-15、IL-16、IL-18等细胞因子与子痫前期的关系；组织开展了胰岛素抵抗与子痫前期、妊娠期糖尿病关系的研究，国内外首先报道了Resistin、Visfatin与子痫前期的相关性和妊娠期糖尿病孕妇妊娠晚期和产后Resistin水平的动态变化。采用串联质谱技术，成功鉴定了10种滋养细胞来源的抑制T淋巴细胞的蛋白质。发表学术论文八十余篇，其中三十余篇发表于SCI源刊物，二十余篇发表于中华系列刊物，获科技成果奖励6项。
研究方向
1、妊娠生理、妊娠免疫耐受机制
2、妊娠并发症（子痫前期、妊娠期肝内胆汁淤积症）病因与发病机理
主要在研课题
1.子宫内膜细胞脂肪酸结合蛋白4在胚胎着床中的作用与机制研究。2011年国家自然科学基金（课题负责人）
2.辅助生殖诱发胚胎源性疾病的风险评估和机制研究。2011年国家重大科学研究计划（973）项目（子课题负责人）
3.Toll样受体7、8介导的炎性反应通路在滋养细胞阻止乙型肝炎病毒宫内传播中的作用。2010年浙江省自然科学基金（课题负责人）
4.胚胎显微操作的安全性研究。2007年国家重大科学研究计划（973）项目（子课题负责人）
近五年成果获奖
1.提高出生人口质量的生殖技术创建、体系优化与临床推广应用：2010年国家科技进步二等奖；
2.阻断出生缺陷、促进子代健康关键技术体系的创建与推广应用：2010年浙江省科技进步一等奖；
3.子宫内膜异位症与女性不孕症的研究：2007年浙江省科技进步奖二等奖；
4.妊娠高血压疾病的临床与基础研究：2007年浙江省科技进步奖三等奖。
近五年发表的代表性论文
1. Chen D, Xia G, Xu P, Dong MY*. Peripartum serum leptin and soluble leptin receptor levels in women with gestational diabetes. Acta Obstet Gynecol Scand. 2010, 89(12): 1595- 1599.
2. Zhang K, He J, Dong MY*. Relationship between umbilical artery Doppler waveform analysis and perinatal prognosis in women with intrahepatic cholestasis of pregnancy. Int J Gynaecol Obstet. 2010 Nov;111(2):187-8.
3. Wang TT, Wu YT, Dong MY, Sheng JZ Leung PC, Huang HF. G546A polymorphism of growth differentiation factor-9 contributes to the poor outcome of ovarian stimulation in women with diminished ovarian reserve. FERTILITY AND STERILITY. 2010; 94(6): 2490-2492.
4. Liang ZX, Dong MY, Cheng Q, Chen DQ. Gestational diabetes mellitus screening based on the gene chip technique. Diabetes Res Clin Pract, 2010 Aug, 89(2):167-73.
5. Qu F, Wang FF, Lu XE, Dong MY, Sheng JZ, Lv PP, Ding GL, Shi BW, Zhang D, Huang HF. Altered aquaporin expression in women with polycystic ovary syndrome: hyperandrogenism in follicular fluid inhibits aquaporin-9 in granulosa cells through the phosphatidylinositol 3-kinase pathway. HUMAN REPRODUCTION, JUN 2010, 25(6): 1441-1450
6. Ding GL, Chen XJ, Luo Q, Dong MY, Wang N, Huang HF. Attenuated oocyte fertilization and embryo development associated with altered growth factor/signal transduction induced by endometriotic peritoneal fluid. FERTILITY AND STERILITY, MAY 2010, 93(8): 2538-2544
7. Wei J, Wang HM, Yang XF, Dong MY, Wang ZP. Altered gene profile of placenta from women with intrahepatic cholestasis of pregnancy. Arch Gynecol Obstet, 2010 May, 281( 5): 801-10
8. Lou H, Ding W, Dong MY, Zhu Y, Zhou C, Wang Z, Yang X, Yao Q, Li D, Miao M. The Presence of Hepatitis B Surface Antigen in the Ova of Pregnant Women and Its Relationship with Intra-uterine Infection by Hepatitis B Virus. J Int Med Res, 2010, 38(1): 214-9
9. Tang L, Zhang Y, Pan H, Luo Q, Zhu XM, Dong MY, Leung PCK, Sheng JZ, Huang HF. Involvement of cyclin B1 in progesterone-mediated cell growth inhibition, G2/M cell cycle arrest, and apoptosis in human endometrial cell. Reprod Biol Endocrinol, 2009, 7:
10. Shangguan XJ, Liu FJ, Wang HZ, He J, Dong MY*. Alterations in serum adipocyte fatty acid binding protein and retinol binding protein-4 in normal pregnancy and preeclampsia. Clinica Chimica Acta, 2009, 407: 58-61
11. Chen DQ, Wang HZ, Huang HF, Dong MY*. Vascular Endothelial Growth Factor Attenuates Nω-Nitro-L-Arginine Methyl Ester-Induced Preeclampsia-Like Manifestations in Rats. Clinical and Experimental Hypertension. 2008 Oct, 30(7): 606- 615.
12. Chen X, Qian X, Chen H, Dong M*. Serum levels of nitric oxide metabolites during labour with or without combined spinal-epidural analgesia. EUROPEAN JOURNAL OF ANAESTHESIOLOGY. 2008 Sep, 25 (9): 708-713
13. Feng C, Wang LQ, Dong M, Huang HF. Need for standardization and confirmation of STS deletions on the Y chromosome – Reply. FERTILITY AND STERILITY. 2008 Aug, 90 (2): 464-464 
14. Feng C, Wang LQ, Dong M*, Huang HF. Assisted reproductive technology may increase clinical mutation detection in male offspring. FERTILITY AND STERILITY, 2008 Jul, 90(1): 92-96. 
15. Huang H, Dong M*. The effect of trohphoblasts on T lymphocytes and the role of indoamine 2,3-dioxigenase. Human Reproduction. 2007 Jul, 22 (Supl 1): 112-112 Meeting abstract O028. 
16. Minyue Dong*, Guolian Ding, Jun Zhou, Hanzhi Wang,Yi Zhao, Hefeng Huang. The effect of trohphoblasts on T lymphocytes: Possible regulatory effector molecules--A proteomic analysis. Cellular Physiology and Biochemistry, 2008, 21:463-472. 
17. Wensheng HU, Zhengping WANG，Hanzhi WANG, Hefeng HUANG and Minyue DONG*. Serum Visfatin Levels in Late Pregnancy and Preeclampsia. Acta Obstet Gynecol Scand, 2008 April, 87(4): 413-418. 
18. Dongxiao Hu, Zhengping Wang, Wuwen Zhang, Hanzhi Wang, and Minyue Dong*. Alteration of Peripheral CD4+CD25+ Regulatory T Lymphocytes in Pregnancy and Preeclampsia. Acta Obstet Gynecol Scand, 2008, 87(2): 190-194. 
19. Qingxia Meng, Huijuan Gao, Chengming Xu, Minyue Dong, Xia Sheng, Jiangzhong Sheng, Hefeng Huang. Reduced Expression and Function of Aquaporin-3 in Mouse Metaphase II Oocytes Induced by Controlled Ovarian Hyperstimulation Were Associated with Subsequent Low fertility Rate. Cell Physiol and Biochem, 2008; 21: 123-128.
20. Li Mei-Gen, Ding Guo-Lian, Chen Xi-Jing, Lu Xi-Ping, Dong Li-Jun, Dong Min-Yue, Yang Xiao-Fu, Lu Xiu-E and Huang He-Feng. Association of serum and follicular fluid leptin concentrations with granulosa cell phosphorylated signal transducer and activator of transcription 3 expression in fertile patients with polycystic ovarian syndrome. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM. 2007, 92 (12): 4771-4776
21. Xie ZW, Shi HY, Zhou CY, Dong MY, Hong LH, Jin HM. Alterations of estrogen receptor-alpha and -beta in the anterior vaginal wall of women with urinary incontinence. EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY. 2007 Oct, 134(2): 254-258. 
22. 王浛知，胡文胜，王正平，董旻岳*。子痫前期患者血清白介素16水平的变化。中华妇产科杂志，2007, 42(11):770-1。
23. Chen DQ, Fang Q, Cai Y, Wang HZ, Huang HF, Minyue Dong*. Serum resistin in gestational diabetes mellitus and early postpartum. Clinical Endocrinology, 2007, 67(2): 208-211
24. Shiming Lu, Hanzhi Wang, Yali Sun, Yaping Shi, Hefeng Huang, Minyue Dong*. Serum IL-16, not IL-15, was elevated in early second trimester of pregnancy in women who subsequently developed preeclampsia. Clinica Chimica Acta, 2007, 383:175-177 
25. Cai J, Lou HY, Minyue Dong, Lu XE, Zhu YM, Gao HJ and Huang HF. Poor ovarian response to gonadotropin stimulation is associated with low expression of follicle-stimulating hormone receptor in granulosa cells. Fertility and Sterility, 2007, 87(6): 1350-1356 
26. Wensheng Hu, Hanzhi Wang, Zhengping Wang, Hefeng Huang, Minyue Dong*. Elevated serum levels of interleukin-15 and interleukin-16 in preeclampsia. Journal of Reproductive Immunology, 2007, 73(2): 166-171 
27. Minyue Dong, Hanzhi Wang, Hefeng Huang. Alterations of Serum Cathepsins B and L in Preeclampsia. Clinica Chimica Acta, 2007, 377/1-2: 285-287
28. Yu Zhang, Xu CM, Zhu YM, Minyue Dong, Qian YL, Jin F, Huang HF. Preimplantation genetic diagnosis for Down syndrome pregnancy. Journal of Zhejiang University Science B, 2007, 8(7): 515-521