标题：高晓冬
个人简介
姓名：高晓冬
性别：男
出生日期：1965年1 月
职称：教授
学习及研究工作经历
1984.4-1988.3 日本山梨大学工学部 获学士学位 
1988.4-1990.3 日本山梨大学工学研究科 获硕士学位 
1990.4-1994.3 日本东京大学农学研究科 获博士学位 
1995.4-1998.3 日本国立生命科学和技术研究所（NIBH）博士后 
1998.6-2002.6 美国纽约州立大学 研究员 
2002.3-2003.7 美国纽约州立大学 助理教授 
2003.8-2006.5 日本国立产业合研究所（AIST）糖锁研究中心 主任研究员 
2006.5-2011.8 日本北海道大学 先端生命科学研究院 副教授 
2011.9- 江南大学生物工程学院 教授
学术及社会兼职
糖锁生物学会 会员（Society for Glycobiology）
日本农艺化学会 会员（Japan Society for Bioscience, Biotechnology, and Agrochemistry）
日本生物分子学会 会员（The Molecular Biology Society of Japan）
日本酵母遗传学会 会员（Yeast Genetics Society of Japan）
研究领域
糖生物学 (glycobiology)，酶学 (enzymology)，微生物学 (microbiology)，生物工程 (biotechnology)，酵母遗传学 (yeast genetics) 和糖化学 (carbohydrate chemistry)
主要论著
1）Lu, J. Takahashi, T. Ohoka A, Nakajima K, Hashimoto, R. Miura, N. Hiroyuki Tachikawa, H. and Gao, X-D. (2011) Alg14 organizes the formation of a multi-glycosyltransferase complex required for initiation of lipid-linked oligosaccharide biosynthesis. Glycobiology. (In press)
2）Gao, X-D., Moriyama, S., Miura, N., Dean, N. and Nishimura, S-I. (2008) Interaction between the C-termini of Alg13 and Alg14 mediate formation of the active UDP-N-acetylglucosamine transferase complex. J. Biol. Chem., 283: 32534-32541.
3) Gao, X-D., Tachikawa,H., Sato,T., Jigami,Y. and Dean,N. (2005) Alg14 recruits Alg13 to the cytoplasmic face of the endoplasmic reticulum to form a novel bipartite UDP-N-acetylglucosamine transferase required for the second step of N-linked glycosylation. J. Biol. Chem., 280: 36254 – 36262
4)Gao, X-D, Wang, J., Keppler-Ross, S. and Dean, N. (2005) ERS1 encodes a functional homologue of the human lysosomal cystine transporter. FEBS Journal. 272(10): 2497-511. 
5)Gao, X-D., Nishikawa, A., Dean, N. (2004) Physical interactions between the Alg1, Alg2, and Alg11 mannosyltransferases of the endoplasmic reticulum. Glycobiology. 14 (6): 559-70. 
6)Gao, X-D., Nishikawa, A., and Dean, N. (2001). Identification of a conserved motif in the yeast GDP-mannose transporter required for nucleotide sugar binding. J. Biol. Chem.276: 4424-4432. 
7) Gao, X-D. and Dean, N. (2000). Distinct protein domains of the yeast Golgi GDP-mannose transporter mediate oligomer assembly and export from the endoplasmic reticulum. J. Biol. Chem., 275: 17718-17727. 
8) Gao, X-D., Kaigorodov, V. and Jigami, Y. (1999) YND1, a homologue ofGDA1, encodes membrane bound apyrase required for Golgi N- and 0-glycosylation inSaccharomyes cerevisiae. J. Biol. Chem., 274: 21450 – 21456.
9)Gao, X-D., Katsumoto, T. and Onodera, K. (1995) Purification and characterization of chitin deacetylase from Absidia coerulea. J. Biochem., 117: 257-263. 
10)Nakajima KI, Kanno Y, Nakamura M, Gao X-D, Kawamura A, Itoh F, Ishisaki A., (2011) Bovine milk lactoferrin induces synthesis of the angiogenic factors VEGF and FGF2 in osteoblasts via the p44/p42 MAP kinase pathway. Biometals, in press 
11) Hinou, H., Miyoshi R., Takasu Y, Kai H., Kurogochi M., Arioka S., Gao, X-D., Miura N., Fujitani, N., Otomo S., Yoshinaga, T., Fujiwara, T., Noshi, T., Togame, H., Takemoto, H., and Nishimura, S-I. (2011) Novel Strategy for Neuraminidase Inhibitors Using Mechanism-based Labeling Information. Chem. Asian J, 1048-1056. 
12) Hashimoto R., Fujitani N., Takegawa Y., Kurogochi M., Matsushita T., Naruchi K., Ohyabu N., Hinou H., Gao X-D., Manri N., Satake H., Kaneko A., Sakamioto T., and Nishimura S-I., (2010) "An efficient approach for the characterization of mucin type glycopeptides: The effect of O-glycosylation on the conformation of synthetic mucin peptides", Chem. Eur. J., 17, 2393-2404 
13) Yoshimura, Y., Matsushita, T., Fujitani, N., Takegawa, Y., Fujihira, H., Naruchi, K., Gao, X-D., Manri, N., Sakamoto, T., Kato, K., Hinou, H. and Nishimura, S-I. (2010) Unexpected Tolerance of Glycosylation by UDP-GalNAc:Polypeptide α-N-Acetylgalactosaminyltransferase Revealed by Electron Capture Dissociation Mass Spectrometry: Carbohydrate as Potential Protective Groups. Biomchem J. 49, 5929-5941
14) Ishihara, M., Suda, Y., Inoue, I., Tanaka, T., Takahashi, T., Gao, X-D., Fukui, Y., Ihara, S., Neiman, AM. and Tachikawa, H. (2009) Protein Phosphatase Type 1-Interacting Protein Ysw1 Is Involved in Proper Septin Organization and Prospore Membrane Formation during Sporulation. Eukaryot Cell.8 (7): 1027-1037 
15) Averbeck, N., Gao, X-D., Nishimura, S-I. and Dean, N. (2008) Alg13, the catalytic subunit of the ER UDP-GlcNAc glycosyltransferase, is a target for proteasomal degradation. Mol Biol Cell.19 (2): 2169-2178 
16) Nakajima, K., Nakamura, M., Gao, X-D., Kozakai, T. (2008) Possible Involvement of Prolactin in Synthesis of Lactoferrin in Bovine Mammary Epithelial Cells. Bioscience, Biotechnology, and Biochemistry,72 (4): 1103-1106 
17) Saida, K., Uchida, T., Usui, A., Gao, X-D., Tomizuka, N., Oka, S. and Masuda, H. (2000) 
The endothelin-2 / Vasoactive intestinal contractor (VIC) gene: Expression and promoter activity in PC12 rat pheochromocytoma cells, J Cardiovasc Pharmacol.36: S9-11. 
18) Tachikawa, H., Funahashi, W., Takeuchi, Y., Nakanishi, H., Nishihara, R., Katoh, S., Gao, X-D., Mizunaga, T. and Fujimoto, D. (1997) Overproduction of Mpd2p suppresses the lethality of protein disulfide isomerase depletion in a CXXC sequence dependent manner. Biochem Biophys Res Commun, 239: 710-714.
19) Saida, K., Gao, X-D., Matsui, M. and Mitsui, Y. (1996) Vasoactive intestinal contractor (VIC) / mouse ET-2 and VIC receptor. Journal of Clinical Medicine,54 (4): 1115-1121.
20) Tachikawa, H., Takeuchi, Y., Funahashi, W., Miura, T., Gao, X-D., Fujimoto, D., Mizunaga, T. and Onodera, K. (1995) Isolation and characterization of a yeast gene, MPD1, the overexpression of which suppresses inviability caused by protein disulfide isomerase depletion. FEBS Letters, 369: 212-216.
科研项目
2006 -2007日本科学技术振兴机构 『シーズ発掘试験』研究费 项目主任；经费：2,000,000 日元 
2009-2012 日本科学研究费补助金基磐研究 (C) 项目主任； 经费：5,000,000 日元 
2009-2011 日本科学技术振兴费 『未来创薬・医疗イノベーション拠点形成』 
配合主任； 分担经费：30,000,000 日元 
2010-2011 日本自然科学研究机构共同利用研究费 项目主任； 经费：300,000 日元
所获专利
1)『A yeast model for screening mutations in cystinosis』;Xiao-Dong Gao and Neta Dean; R-7651(USA); 
02/26/03
2) 『フコース结合タンパク质合成系遗伝子が导入された酵母形质転换体』地神　芳文、千木良　
裕子、高　暁冬、董四君；11/113081(USA)、04/23/2005
3) 『精制されたキチンデアセチラーゼ』　高　暁冬、小野寺　一清; 特开平7－231787(JAPAN); 09/05/95（平成7年9月5日）特愿平6-26635 (JAPAN); 02/24/94（平成6年2月24日）
4) 『フコース结合タンパク质合成系遗伝子が导入された酵母形质転换体』地神　芳文、千木良　裕子、高　暁冬、董四君；特愿2004-128796 (JAPAN)、04/15/2004
荣誉与奖励
1) 中国教育部派遣本科留学生 (April 1984 --- March 1993)
2) Selected and Interviewed as “Dedicated postdoc” by AAAS (ref: Science,294 (5541): p410 2001)