标题：宋国杰
简历
2006.9-至今   嘉兴学院医学院 院长
2005.8-2006.8扬州市第一人民医院心内科副主任、中心实验室业务指导主任、科教处副主任。
1980.9－1983.3大连医学院心血管系硕士研究生毕业，1983.4－1987.10在天津市胸科医院/心血管研究所心内科从事临床工作
1987.11－1989.12英国伦敦Brompton皇家国家心肺医院心脏科研究员
1990.1－1994.1英国伦敦大学Charing Cross & Westminster 医学院及Westminster 医院心脏科研究员
1994.2－1996.12美国辛辛那提大学医学院心脏科博士后研究员
1997.1－1998.7美国辛辛那提大学医学院心脏科高级研究员
1998.8－2005年英国伦敦大学 University College医学院心脏科/生理系高级研究员、爱尔兰皇家圣三一学院药理系心血管研究室/St Jame’s医院心脏科高级研究员。在国外工作期间，曾经于1999-2001年协助天津胸科医院/心血管病研究所陈树勋教授建立天津市分子心脏病学研究中心，设计了探查MMP在心肌梗塞后心室重构中的分子机制等项目。
2002－2005年兼职任中国山东省立医院中心实验室主任、内科副主任、心血管中心副主任，院长特别助理，为该院建立了分子心脏病学研究室，设计开展了在细胞和分子水平研究病毒性心肌炎的科研和临床项目。
2003－至今担任中国人民解放军总医院、军医进修学院基础医学研究所分子生物学室客座研究员，合作开展了小分子热休克蛋白HSP20基因在心脏病患者中的突变分布及其意义等项目。在国际国内学术期刊发表论文40余篇，其中收录SCI期刊12篇。主编《临床分子心脏病学现代心脏病学的新领域》一书。
教育
1958.9-1964.8 天津市塘沽区明星路小学 学生
1973.9-1977.2 吉林医学院医疗系 学生
1980.9-1983.3 大连医学院心血管系 硕士研究生
1990.1-1994.1 英国伦敦大学Charing Cross & Westminster 医学院心血管专业 博士研究生工作经历
1977.3-1980.8 天津市塘沽医院内科 住院医师
1983.4-1987.10 天津市胸科医院心内科 住院医师、总住院医师、主治医师
1987.11-1989.12 英国伦敦Brompton医院心脏科 研究员
1990.1-1994.1 英国伦敦大学Charing Cross & Westminster 医学院心脏科 研究员
1994.2-1997.2 美国Cincinnati大学医学院心脏科 博士后研究员
1997.2-1998.7 高级研究员
1998.8-2003.8 英国伦敦大学 University College医学院内科/生理系 高级研究员
2003.9-2005.7 爱尔兰Dublin大学TrnityCollege /St Jame’s医院心脏科 高级研究员
2005.8-2006.8 扬州大学第二临床医学院心内科 副主任、中心实验室主任、博士生导师
2006.9-至今   嘉兴学院医学院 院长
特长
1. 心血管病临床诊断与治疗
2. 心血管病基础研究
3. 医学心理学和临床心理学的应用和教育
专业学会会员
1. 中华医学会 (1985)
2. 英国皇家医学会 (1988)
3. 美国心脏协会 (1995)
4. 国际心脏研究学会 (1995)
已发表文章
1. Continuous observing ECG PTFv1 to determine left ventricular function of patients with AMI. (心电图PTFv1动态观察判断急性心肌梗塞患者左室功能的价值) 陈树勋, 宋国杰, 梁爽霖 天津医药 1986;15:29
2. An echocardiographic study in AMI patients and an attempt to predict pump failure by ECHO indices (超声心动图预判急性心肌梗塞患者泵衰竭) 陈树勋, 宋国杰 中华心血管病杂志 1987;15:316
3. Using ECG Q-Tc and R wave changes to diagnose coronary artery disease (使用心电图校正Q-T间期和R波改变诊断冠心病) 陈树勋，宋国杰 中华心血管病杂志 1988;16:27)
4. Left ventricular dysfunction and obstructive lung disease: an echocardiographic and angiographic study of cor pulmonale patients with decreased mitral E-F slope 
Song G and Oldershaw P J International Journal of Cardiology 1989;25:47
5. Atria-ventricular interaction and the origins of "a" wave in left ventricular disease. Jones CJH, Song G ,Gibson DG British Heart Journal 1991;65(1):31
6. Myocardial ischemia in identical twins discordant for type one diabetes. Dubrey S, Song G , Akhras F, Hardman T, Noble MIM and Leslie RDG European Heart Journal　 1991; (12) Supplemen:223
7. Haemodynamic and neurohumoral response in heart failure produced by rapid ventricular pacing. Travill C M, Williams T D, Pate P, Song G , Chalmers J, Lightman SL, Sutton R, Noble M I M. Cardiovascular Research 1992;26(8):783
8. Does insulin dependent diabetes (IDDM) cause myocardial ischemia: a study of 70 identical twins IDDM. Dubrey S, Akhras F, Song G , Noble M I M , et al. Clinical Science 1992;82:(3)4
9. The effects of renal denervation on the renal and humoral response to fluid load. Song G, Belcher P, Travill C M, Noble M I M , et al. European Heart Journal 1993; (14) Supplemen:1639
10. Heart failure induced by rapid ventricular pacing enhanced renin gene expression. Song G, Gao Y, Belcher P, Noble M I M, et al. European Heart Journal 1993; (14) Supplemen:413
11. Myocardial renin gene expression in heart failure induced by rapid ventricular pacing in association with renal denervation. GJ Song, Y Gao K. Kanayama, PR Belcher, S. Dubrey, M. I. M. Noble. European Heart Journal 1994; (15) Supplemen:199
12. Myocardial neuropeptide Y gene expression in heart failure induced by rapid ventricular pacing. GJ Song, Y Gao, D. Larhammar, PR Belcher, S. Dubrey, M. I. M. Noble. European Heart Journal 1994; (15) Supplemen:199
13. Exercise electrocardiography and aortic Doppler velocimetry in asymptomatic identical twins discordant for type I (insulin dependent) diabetes. Dubrey S, Akhars F, Guojie Song , Hardman T, Travill C, Hynd J, Noble MI, Lo SS, Leslie RD. British Heart Journal 1994;71(4):341
14. Depressed intracellular Ca2+ homeostasis and mechanical properties of cardiomyocytes in annexin VI transgenic mouse. Guojie Song , Ann-Marie E. Gunteski-Hamblin, Gerald W. Dorn II, Darryl L. Kirkpatrick, John R. Dedman, Richard A. Walsh. Journal of the American College of Cardiology Special Issue: 1995; 277A
15. Abnormal Na+/Ca2+ Exchanger Activity in Annexin VI Overexpression Transgenic Mice. Guojie Song , Gerald W. Dorn II, Ann-Marie E. Gunteski-Hamblin, Darryl L. Kirkpatrick, John R. Dedman, Richard A. Walsh. Journal of Molecular and Cellular Cardiology 1995; 27(6): A133
16. Unchanged intracellular Ca2+ levels and depressed mechanical properties of cardiomyocytes in myosin light chain transgenic mice. Guojie Song , Darryl L. Kirkpatrick, Gerald W. Dorn II, Joe Palermo, Jeffrey Robbins, Richard A. Walsh. Circulation 1995;92(8):I-321
17. Abnormal Na+/Ca2+ Exchanger Activity in Transgenic Mice with Cardiac Specific Overexpression of Annexin VI. Guojie Song , Darryl L. Kirkpatrick, Ann-Marie E. Gunteski-Hamblin, Gerald W. Dorn II, John R. Dedman, Richard A. Walsh. Circulation 1995;92 (8):I-697
18. Annexin VI overexpression in transgenic mouse heart alters cardiac myocyte contractile function, calcium dynamics and heart pathology. Gunteski-Hamblin AE, Guojie Song , Walsh RA, Frenzke M, Dorn II GW, Kaetzel MA, Horseman ND, Dedman JR. Am J Physiol Physiol 1996;270 (3 Pt 2):H1091-100
19. Decreased Ca2+ sensitivity: a reason for depressed mechanical properties of cardiomyocytes from myosin light chain overexpression transgenic mice. Guojie Song , Darryl L. Kirkpatrick, Gerald W. Dorn II, Jeffrey Robbins, Richard A. Walsh. Journal of the American College of Cardiology 1996;27 (2, Supplement): 277A
20. Altered protein levels of cardiac annexins in human end-stage congestive heart failure. Guojie Song , Corinn M. Pawloski-Dahm, Darryl L. Kirkpatrick, Richard A. Walsh. Circulation 1996;94 (8):I-725
21. Natriuresis caused by blood volume expansion in dogs is not mediated by the renal nerves. Drake-Holland AJ, Song G, Belcher PR, Noble MI Experiment Physiology 1996;81 (2):285
22. Down-regulated annexin VI mRNA and protein levels in guinea pigs with aortiac banding-induced heart failure. Guojie Song , Nancy Ball, John R. Dedman and Richard A. Walsh. European Heart Journal 1997; 18 (Suppl):512
23. Transcripational regulation of cardiac annexins in human end-stage congestive heart failure. Guojie Song , Begonia Campos, Lynne E. Wagoner, John R. Dedman, Richard A. Walsh. Circulation 1997;96(8):I-138
24. Altered cardiac annexin mRNA and protein levels in the left ventricle of patients with end-stage heart failure. Guojie Song , Begonia Campos, Lynne E. Wagoner, John R. Dedman, Richard A. Walsh. Journal of Molecular & Cellular Cardiology, 1998;30:443
25. Effects of total replacement of atrial myosin light chain-2 with the ventricular isoform in atrial myocytes of transgenic mice Pawloski-Dahm CM, Song G, Kirkpatrick DL, Palermo J, Gulick J, Dorn GW 2nd, Robbins J, Walsh RA. Circulation 1998; 97(15):150827.
26. Protein Kinase C-b2 expression and activity in non-failed and failed human hearts Nancy Bowling, Guojie Song , Richard A. Walsh, George L. King, George E Sandusky, Chris J. Vlahos. Circulation 1999;99(3):384
27. PKC translocation without changes in Gq and PLC-b protein abundance in cardiac hypertrophy and failure Jalili T, Song G , Takeishi Y, Ball NA, Howles G, Walsh RA Am J Physiol 1999 Dec;277(6 Pt 2):H2298
28. Altered mechanical properties and intracellular calcium homeostasis in cardiomy-
ocytes from mice with targeted disruption of the annexin VI Gene. Guojie Song , Sian Harding, Michael Duchen, Peter O’Gara, Tim Hawkins, Stephen Moss Circulation 1999;100(18):I762
29. Changes in Ca2+ cycling proteins underlie cardiac action potential prolongation in a pressure-overloaded guinea pig model with cardiac hypertrophy and failure. Ahmmed GU, Dong PH, Song G, Ball NA, Xu Y, Walsh RA, Chiamvimonvat N Circulation Research 2000 Mar 17;86(5):558-570
30. Increased cardiac expression of the Na+/Ca2+ exchanger may be responsible for altered myocyte intracellular Ca2+ cycling in mice with targeted disruption of the annexin-6 gene. Guojie Song , Richard E. Tunwell, Timothy E. Hawkins, Stephen E. Moss Circulation 2000;102(18): II141
31. Targeted Disruption of the Annexin 6 GeneImproves Resistanceto Hypoxia Injury in the Cardiaomyocyte. Guojie Song, Timothy E. Hawkins, Stephen E. Moss Circulation 2001;104(14): I330
32. Altered mechanical properties and intracellular calcium signaling in cardiomyocytes from annexin 6 null-mutant mice. Song G, Harding SE, Duchen MR, Tunwell R, O'Gara P, Hawkins TE, Moss SE. FASEB J. 2002 Apr;16(6):622-4.
33. Increased intracellular ATP in adult mice cardiomyocytes treated with ACE inhibitor. Guojie Song , Ying Hong, John F. Martin, Jorge D. Erusalimsky Circulation 2003;Suppl 11(22): 98
34. Dynamic changes in myocardial matrix metalloproteinase activity in mice with viral myocarditis. Meng XH, Wang Y, Zhuang JX, Han XZ, Chen Y, Jin YP, Wang YL, Yu YH, Spires JP, Song GJ. Chin Med J (Engl). 2004 Aug;117(8):1195
35. Novel cardioprotective effects by the small heat shock preotein Hsp20. Fan GC, Yuan Q, Qian J, Nicolaou P, Song G, Chen G, Chu G, Kranias EG. Circulation Research, 2005, 97 (2): E18
36. Alterations in vascular matrix metalloproteinase due to ageing and chronic hypertension: effects of endothelin receptor blockade. Spiers JP, Kelso EJ, Siah WF, Edge G, Song G, McDermott BJ, Hennessy M. J Hypertens. 2005 Sep; 23(9):1717-24.
37. Adrenoceptor blockade alters plasma gelatinase activity in patients with heart failure and MMP-9 promoter activity in a human cell line (ECV304). Song G, Hennessy M, Zhao YL, Li Q, Han WD, Qi Y, Zhao WN, Silke B, Barry M, Doyle R, Spiers JP. Pharmacol Res. 2006 Jul;54(1):57-64.
38. Statin therapy for patients with chronic heart failure. Gong K, Song G, Zhang Z.  Am J Cardiol. 2006 Sep 1;98(5):707
39. Small heat-shock protein Hsp20 attenuates beta-agonist-mediated cardiac remodeling through apoptosis signal-regulating kinase 1. Fan GC, Yuan Q, Song G, Wang Y, Chen G, Qian J, Zhou X, Lee YJ, Ashraf M, Kranias EG. Circ Res. 2006 Nov 24;99(11):1233-42.
40. Activation of immune and inflammatory systems in chronic heart failure: novel therapeutic approaches. Gong KZ, Song G, Spiers JP, Kelso EJ, Zhang ZG.   Int J Clin Pract. 2007 Apr;61(4):611-21.
已出版专业书籍
宋国杰 主编：《临床分子心脏病学&frac34;&frac34;现代心脏病学的新领域》 
天津科技出版社出版， 2001年5月， 中国，天津
获奖情况
1987-1988   Sino-British Scholar Fellowship (UK) 英国英中基金会学者奖
1989             Wellcome Trust Outstanding Scholar Travel Fellowship (UK)
英国              Wellcome 信托基金会学者出访讲学奖
1995             American Heart Association Research Fellowship (USA)美国心脏协会研究奖
博士论文题目
The Haemodynamic, Neurohormonal and Molecular Biological Response in Pacing-Induced Heart Failure with Renal or Cardiac Denervation 
肾脏和心脏去神经时起搏诱发的心力衰竭中血液动力学、神经激素系统和分子生物学的反应性改变