标题：郭晓奎
个人简介
郭晓奎，微生物学教授、博士生导师。现任上海交通大学基础医学院副院长；上海交通大学医学院基础医学教学实验中心主任、病原生物学教研室/临床微生物学教研室主任；上海交通大学医学科学研究院分子微生物学课题组PI。 国家高等学校教学名师,全国优秀教师，全国“十一五”教育科研先进个人，国家精品课程“医学微生物学”负责人，上海市优秀教学团队负责人，“十一五”和“十二五”国家规划教材“病原生物学”主编。关于钩端螺旋体和益生菌安全性的研究处于国际领先地位
主要兼职
中华预防医学会微生态学分会副主任委员；上海市微生物学会副理事长；中国微生物学会普及与教育工作委员会副主任委员；上海市食品微生物学专业委员会主任委员； 上海市预防医学会微生态学专业委员会主任委员； 上海市食品学会乳酸菌专业委员会副主任委员； 上海市海洋微生物学专业委员会副主任委员； 上海市医学病毒学专科学会委员； 中国医学微生物学和免疫学专业委员会委员； 中国人兽共患病病原专业委员会委员； 中国微生物学会普及与教育工作委员会委员； 《中国人兽共患病学报》副主编； 《中国微生态学杂志》编委； 《国际生物制品学杂志》编委； 《微生物与感染杂志》编委； 《上海交通大学学报》（医学版）编委; 《医学参考报》（微生物学与免疫学）编委
研究方向
耐药细菌控制技术研究
钩端螺旋体分子生物学研究。
人体微生态学与益生菌安全性研究
个人荣誉
综合奖励2011年获国家级教学名师称号
2010年获全国教育科研先进工作者
2010年上海交通大学校长奖
2009年获全国优秀教师称号 
2009年获上海市教学名师称号 
2009年被评为上海市优秀学科带头人 
2008年被评为上海交通大学医学院“优秀教师” 
2007年获教育部宝钢教育基金会“优秀教师奖” 
2005年获上海第二医科大学首届“校长奖” 
1996年获教育部霍英东基金会“青年教师奖” 
1996年获黑龙江省“青年科技奖” 
1995年获哈尔滨医科大学”优秀青年教师”教学研究奖励2010年领导的“病原生物学”团队被评为上海市优秀教学团队 
2010年获全国“十一五”教育科研优秀成果特等奖
2009年主编的“病原生物学”获上海交通大学优秀教材一等奖 
2009年获上海市教学成果三等奖 
2008年获上海交通大学教学成果特等奖 
2008年主持的“病原生物学”被评为“双语示范课程” 
2007年领导的“病原生物学”团队被评为上海交通大学优秀教学团队 
2005年主持的“医学微生物学”课程被评为国家精品课程
2003年主讲的“医学微生物学”课程被评为上海市精品课程 
1996年获黑龙江省教学成果二等奖。科学研究奖励钩端螺旋体全基因组测序和部分功能的研究 2004年上海市科技进步奖二等奖。 
肺炎克雷伯杆菌的分子生物学研究及在院内感染监控中的应用获1999年黑龙江省医药卫生科学技术进步一等奖和1999年获黑龙江省科学技术进步三等奖。 
克隆识别技术研究及其应用获1997年获黑龙江省教育委员会科学技术进步一等奖和1997年获黑龙江省科学技术进步三等奖。 
住院患者肺炎杆菌感染的分子流行病学研究获1997年黑龙江省教育委员会科学技术进步一等奖。 
淋病的病原学鉴别诊断的研究获1995年哈尔滨市科学技术进步三等奖。 
柯萨奇病毒性心肌炎诊断的研究获1994年黑龙江省医药卫生科学技术进步一等奖。 
淋球菌基因探针的制备及哈市淋球分子流行病学研究获1994年黑龙江省科学技术进步二等奖。 
绿脓杆菌质粒图谱血清型和耐药谱的研究获1993年黑龙江省科学技术进步三等奖。其他奖励2010年所领导的“病原生物学教研室”获全国教育科研先进集体
2009年所领导的“病原生物学教研室”获“上海市教育系统先进集体”称号 
2009年所领导的“病原生物学教研室”获“上海市文明班组”称号 
2008年所领导的“病原生物学教研室”获“上海交通大学医学院文明班组”称号
个人作品
主要著作和教材郭晓奎（主编）病原生物学-医学微生物学 科学出版社 2012
郭晓奎（主编）病原生物学-医学寄生虫学 科学出版社 2012
郭晓奎（主审）医学微生物学实验教程 人民卫生出版社 2011
郭晓奎（主编）医学微生物学实验技术 人民卫生出版社 2010
郭晓奎(主编) 感染与优生优育 第二军医大学出版社 上海 2009
郭晓奎（主编）病原生物学教育教学 第二军医大学出版社 上海 2008
郭晓奎（主编）病原生物学纲要（英文版） 科学出版社 2008
郭晓奎（主编）病原生物学 科学出版社 2007
郭晓奎(主编) 细胞微生物学 第二军医大学出版社 上海 2004
郭晓奎(主编) 克隆识别 北京医科大学和中国协和大学联合出版社 北京1994部分论文Zhang ZY, Sun ZQ, Wang ZL, Hu HR, Wen ZL, Song YZ, Zhao JW, Wang HH, Guo XK*, Zhang SL. Identification and pathogenicity analysis of a novel non-tuberculous mycobacterium clinical isolate with nine-antibiotic resistance.Clin Microbiol Infect.2013; 19(1):91-6.
Zhang SM,Qiu J,Tian F,Guo XK,Zhang FQ,Huang QFCorrosion behavior of pure titanium in the presence of Actinomyces naeslundii.J Mater Sci Mater Med.2013 Feb 21. [Epub ahead of print]
Zelin Cui, Yuhua Zhou, Hong Li, Yan Zhang, Shenjie Tang, Xiaokui Guo. Complex sputum microbial composition in patients with pulmonary tuberculosis. BMC microbiology. 2012, 12:276
Zelin Cui, WenbinShen, Zheng Wang, Haotian Zhang, Rao Me, Yanchun Wang, LingbingZeng, Yongzhang Zhu, Jinhong Qin, Ping He, and Xiao-Kui Guo*. Complete Genome Sequence of Klebsiellapneumoniae phage JD001. Journal of Virology. 2012, 86(24):13843.
Zelin Cui, Zhen Song, Yanchun Wang, LingbingZeng, WenbinShen, Zheng Wang, Qingtian Li, Ping He, Jinhong Qin, and Xiao-Kui Guo*. Complete Genome Sequence of wide host-range Staphylococcus aureus phage JD007. Journal of Virology. 2012, 86(24):13880.
Zhou Y, Tao J, Yu H, Ni JJ, Zeng LB, Teng QH, Kim K, Zhao GP, Guo XK*, and Yao YF. Hcp-family proteins secreted via type VI secretion system coordinately regulate Escherichia coli K1 interaction with human brain microvascular endothelial cells. Infection and Immunity, 2012 , 80(3):1243-51
Zhang ZY, Liu C, Zhu YZ, Wei YX, Tian F, Zhao GP, Guo XK*. Safety assessment of Lactobacillus plantarumJDM1 based on the complete genome. Int J Food Microbiol. 2012 Feb 1;153(1-2):166-70. Epub 2011 Nov 12.
Wei YX, Zhang ZY, Liu C, Malakar PK, Guo XK*.Safety assessment of Bifidobacterium longum JDM301 based on complete genome sequences.World J Gastroenterol. 2012 Feb 7;18(5):479-88.
Zhang MM, Zhao JW, Sun ZQ, Liu J, Guo XK, Liu WD, Zhang SL. Identification of RD5-encoded Mycobacterium tuberculosis proteins as B-cell antigens used for serodiagnosis of tuberculosis. Clin Dev Immunol. 2012; 2012:738043.
Zhang Y, Lou XL, Yang HL, Guo XK, Zhang XY, He P, Jiang XC. Establishment of a leptospirosis model in guinea pigs using an epicutaneous inoculations route.BMC Infect Dis. 2012 Jan 25;12:20.
Li QT, Huang JW, Guo HX, Guo XK, Zhu YZ, Dong K. Bactericidal activity against meticillin-resistant Staphylococcus aureus of a novel eukaryotic therapeutic recombinant antimicrobial peptide.Int J Antimicrob Agents, 2012, 39 (6):496-499.
Peng N, Zhong Y, Zhang Q, Zheng M, Zhao W, Jiang H, Yang C, Guo X, Zhao G.Characterization of acetyl-CoA and propionyl-CoA carboxylases encoded by Leptospira interrogans serovar Lai: an initial biochemical study for leptospiral gluconeogenesis via anapleroticCO(2) assimilation. Acta Biochim Biophys Sin. 2012;44(8):692-702.
Shi, Si-feng, Jia, Jing-fu, Guo, Xiao-kui, Zhao, Ya-ping, Liu, Bo-yu, Chen, De-sheng, Guo, Yong-yuan, Zhang, Xian-long. Toxicity of iron oxide nanoparticles against osteoblasts. JOURNAL OF NANOPARTICLE RESEARCH 2012; 14(9),1091,
Zheng LL, Li YX, Ding J, Guo XK, Feng KY, Wang YJ, Hu LL, Cai YD, Hao P, Chou KC. A comparison of computational methods for identifying virulence factors. PLoS One. 2012; 7(8):e42517.
Shi SF, Jia JF, Guo XK, Zhao YP, Chen DS, Guo YY, Cheng T, Zhang XL.Biocompatibility of chitosan-coated iron oxide nanoparticles with osteoblast cells.Int J Nanomedicine. 2012; 7:5593-602.
Li QT, Zhu YZ, Dong K, Liu C, Zhou YH, Ni YX, Guo XK*. A novel sequence-based coa genotyping method to discriminate nosocomial ethicillin-resistant Staphylococcus aureus isolates. Ir J Med Sci. 2011, 180 (2): 463-8.
Zhong Y, Chang X, Cao XJ, Zhang Y, Zheng H, Zhu Y, Cai C, Cui Z, Zhang Y, Li YY, Jiang XG, Zhao GP, Wang S, Li Y, Zeng R, Li X, Guo XK*. Comparative proteogenomic analysis of the Leptospira interrogans virulence-attenuated strain IPAV against the pathogenic strain 56601. Cell Res. 2011, 21 (8): 1210-29.
Zhao JW, Sun ZQ, Zhang CZ, Yang HG, Yu XL, Wen ZL, Gao YF, Guo XK, Qi YM, Zhang SL. Cloning, expression and immunological evaluation of a short fragment from Rv3391 of Mycobacterium tuberculosis . Ann Microbiol. 2011, 61 (2): 345-353
Zhang ZY, Sun ZQ, Wang ZL, Wen ZL, Sun QW, Zhu ZQ, Song YZ, Zhao JW, Wang HH, Zhang SL, Guo XK*. Complete genome of a novel clinical isolated non-tuberculous mycobacterium strain JDM601.J Bacteriol. 2011, 193 (16): 4300-1.
Zhang SM, Tian F, Huang QF, Zhao YF, Guo XK, Zhang FQ. Bacterial diversity of subgingival plaque in 6 healthy Chinese individuals.Exp Ther Med.2011; 2(5):1023-1029.
Zhang Q, Zhang Y, Zhong Y, Ma J, Peng N, Cao X, Yang C, Zeng R, Guo X, Zhao G. Leptospira interrogans encodes an ROK family glucokinase involved in a cryptic glucose utilization pathway. Acta Biochim Biophys Sin . 2011, 43 (8): 618-29.
Ning R, Zhang X, Guo X, Li Q. Staphylococcus aureus regulates secretion of interleukin-6 and monocyte chemoattractant protein-1 through activation of nuclear factor kappaB signaling pathway in human osteoblasts. Braz J Infect Dis. 2011, 15 (3): 189-94.
Ning R, Zhang X, Guo X, Li Q. Attachment of Staphylococcus aureus is required for activation of nuclear factor kappa B in human osteoblasts. Acta Biochim Biophys Sin. 2010, 42(12): 883-92.
Zhu YZ, Cai CS, Zhang W, Guo HX, Zhang JP, Ji YY, Ma GY,Wu JL, Li QT, Lu CP, Guo XK*. Immunoproteomic analysis of human serological antibodyresponses to vaccination with whole-cell pertussis vaccine (WCV). PLoS One. 2010; 5(11):e13915.
YuhuaZhou, Ping Lin, Qingtian Li, Lizhong Han, HuajunZheng, Yanxia Wei, Zelin Cui, Yuxing Ni, XiaokuiGuo*. Analysis of the microbiota of sputum samples from patients with lower respiratory tract infections. Acta Biochim Biophys Sin. 2010;42(10):754-761.
Wu,Chenyun; Fen, Yan; Qian, Gaochao; Wu, Jianhua; Luo, Jun; Wang, Ying; Chen,Guangjie; Guo, Xiaokui*; Wang, Zhaojun*. α-galactosylceramide protects mice from lethal coxsackie virus B3 infection and subsequent myocarditis. Clin Exp Immunol. 2010, 162(1):178-187.
Wei YX, Zhang ZY, Liu C, Zhu YZ, Zhu YQ, Zheng H, ZhaoGP, Wang S, Guo XK*.Complete genome sequence of Bifidobacterium longum JDM301. J Bacteriol. 2010; 192(15):4076-7.
Qingtian Li,Yuhua Zhou ,Ke Dong ,Xiaokui Guo*. Potential therapeuticefficacy of a bactericidal–immunomodulatory fusion peptide againstmethicillin-resistant Staphylococcus aureus skin infection. 2010. Appl Microbiol Biotechnol . 2010, 86:305–309.
Cai CS, Zhu YZ, Zhong Y, Xin XF, Jiang XG, Lou XL, He P,Qin JH, Zhao GP, Wang SY, Guo XK*.Development of O-antigen gene cluster-specific PCRs forrapid typing six epidemic serogroups of Leptospira in China. BMC Microbiol. 2010; 10:67.
Liu C, Zhang ZY, Dong K, Guo XK. Adhesion and immunomodulatory effects of Bifidobacte riumlactis HN019 on intestinal epithelial cells INT-407. World J Gastroentero.2010; 16(18):2283-90.
Ke Dong, Qingtian Li, Chang Liu, Yunyi Zhang, Guoping Zhao, and Xiaokui Guo. Cloning and characterization of three cheB genes in Leptospira interrogans. Acta Biochim Biophys Sin . 2010, 42 (3): 216-223.
Yang J,Xu J, Chen X, Zhang Y, Jiang X, XiaokuiGuo, and Guoping Zhao. Decrease of Plasma Platelet-Activating Factor Acetylhydrolase Activity inLipopolysaccharide Induced Mongolian Gerbil Sepsis Model. PLoS ONE 2010, 5(2): e9190.
Cao XJ, Dai J, Xu H, Nie S, Chang X, Hu BY, Sheng QH,Wang LS, Ning ZB, Li YX, Guo XK, Zhao GP, Zeng R. High-coverage proteome analysis reveals the first insight of protein modification systems in the pathogenic spirochete Leptospira interrogans. Cell Res. 2010; 20(2):197-210.
Lin W, Yang HL, Yang Y, Hu BY, Tan LZ, Guo XK. Cloning, expression, and immunologicalevaluation of a novel protein belonging to OmpA family in Leptospira interrogans Recent Works on Microbes andInfections in China, World Scientific Publishing Co. Pte. Ltd. , 2009.P1-12
Jiang,XG, Zhang XY, Zhong WJ, Nie YX, Yin WW, Li XW, Guo XK Surveillance of Leptospirosis and the MurineReservoirs in China 2005 Recent Works on Microbes and Infections in China,World Scientific Publishing Co. Pte. Ltd, 2009. P13-19.
Yao Y,Xie Y, Perace D, Zhong Y, Lu J, Tao J,Guo XK, Kim KS.The type IIIsecretion system is involved in the invasion and intracellular survival ofEscherichia coli K1 in humanbrainmicrovascular endothelial cells.FEMS Microbiol Lett. 2009, 300(1):18-24.
JianpingYuan, Ping Li, Jing Tao, Xiaodong Shi, Baoyu Hu, Huabiao Chen and XiaokuiGuo* H.pylori Escape Host Immunoreaction Through Inhibiting ILKExpressionByVacA.Cellular & Molecular Immunology, 2009, 6(3): 191-197.
Zhang ZY, Liu C, Zhu YZ, Zhong Y, Zhu YQ, Zheng HJ, ZhaoGP, Wang SY, Guo XK. Complete genome sequence of Lactobacillus plantarum JDM1.J Bacteriol. 2009Aug;191(15):5020-5021.
Zhang SM, Tian F, Jiang XQ, Li J, Xu C, Guo XK, Zhang FQ.Evidence for calcifying nanoparticles in gingivalcrevicular fluid and dental calculus in periodontitis. J Periodontol. 2009; 80(9):1462-70.
TianF,Yu Y, Chen B, Li HR, Yao YF, Guo XK*. Bacterial, archaeal and eukaryotic diversity in Arctic sediment as revealed by16S rRNA and 18S rRNA gene clone libraries analysis. Polar Biology, 2009, 32(1):93-103.
Zhao W, Chen CY, Zhang XY, Lai WQ, Hu BY, Zhao GP, QinJH, Guo XK*. Molecular characterization of the pL40 protein inLeptospirainterrogans. Can J Microbiol. 2009; 55(6):739-749.
FengCY, Li QT, Zhang XY, Dong K, Hu BY,GuoXK. Immune strategies on single component LipL32 and multi-components recombinant LipL32-41-OmpL1 vaccines against Leptospira. Brazilian Journal of Medical and BiologicalResearch. 2009, 42(9):796-803
Liu C, Zhang ZY, Dong K, Yuan JP, Guo XK*.Antibiotic resistance of probiotic strains of lactic acidbacteria isolated from marketed foods and drugs. Biomed Environ Sci. 2009; 22(5):401-412.
Qin Lu,De-Hong Yu, Chao Fang, Fang Liu, Xun Ye, Yi Zhao, Jie Qin, Xiao-KuiGuo, Min Liang, Fang Hu and Hong-zhuan Chen. Influence of E3 region on conditionally replicative adenovirus mediated cytotoxicity in hepatocellular carcinoma cells. Cancer biology and therapy, 2009, 8(12): 1127-1134.
Yang RF,Guo XK, Yang J, Jiang YQ, Pang B,Chen C, Yao YF, Qin JH, Li QT. Genomic research for important pathogenic bacteria in China. Science in China Series C: Life Sciences, 2009, 52(1):50-63.
JunweiYang, Yixuan Zhang, Jing Xu, Yan Geng, Xiaoying Chen, Hongling Yang, ShengnanWang, Hengan Wang,Xucheng Jiang, XiaokuiGuo, Guoping Zhao. Serum activity of platelet-activating factoracetylhydrolase is a potential clinical marker for leptospirosis pulmonaryhemorrhage.PloS ONE. 2009 4(1): e4181.
Zhu YZ, Li QT, Wang L, Zhong Y, Ding GH, Li G, JiaPL,Shi TL, Guo XK*. Gene expression profiling-based in silico approach toidentify potential vaccine candidates and drug targets against B. pertussis and B. parapertussis.OMICS. 2008 ;12(3):161-169.
Qin JH, Zhang Q, Zhang ZM, Zhong Y, Yang Y, Hu BY, ZhaoGP, Guo XK*. Identification of a novel prophage-like gene cluster actively expressed in both virulent and avirulent strains of Leptospira interrogans serovar Lai. Infect Immun. 2008; 76(6):2411-2419.
Zhang YX, Geng Y, Yang JW, Guo XK, Zhao GP. Cytotoxic activity and probable apoptotic effect of Sph2, asphigomyelinase hemolysin from Leptospira interrogans strain Lai. BMB Rep. 2008. 41(2):119-125.
He P, Sheng YY, Shi YZ, Jiang XG, Qin JH, Zhang ZM, ZhaoGP, Guo XK*. Genetic diversity among major endemic strains of Leptospira interrogans in China. BMC Genomics. 2007. 8:204.[40]
Ying Zou, Guo XK, Mathieu Picardeau, HaiXu, Guoping Zhao. A comprehensive survey on isoleucine biosynthesis pathways in seven epidemic Leptospira interrogans reference strains of China. FEMS Microbiology Letters, 2007, 269(1):90–96.
Li QT,Zhu YZ, Chu JY,Wang YY, Xu YH, Hou QM, Zhang SM,Guo XK*. Protective immunity against Bordetellapertussis by a recombinant DNA vaccine and the effect of coinjection with agranulocyte- macrophage colony stimulating factor gene. Microbiol Immunol, 2006,50(12):929-936.
Sun JC,Xu JL, Cao JP,Liu Q, Guo XK*, Shi TL. Predictionand systematic study of protein-protein interaction networks of Leptospira interrogans. Chinese Science Bulletin, 2006, 51(1):1-10.
Yang HL, Zhu YZ, Qin JH, He P, Jiang XC, Zhao GP, Guo XK.In silico and microarray-based genomic approaches to identifying potential vaccine candidates against Leptospira interrogans. BMC Genomics. 2006. 16;7:293.
Li QT, Zhu YZ, Chu JY, Dong K, He P, Feng CY, Hu BY,Zhang SM, Guo XK. Granulocyte-macrophage colony-stimulating factor DNA prime-protein boost strategy to enhance efficacy of a recombinant pertussis DNA vaccine. Acta Pharmacol Sin. 2006 Nov;27(11):1487-1494.
Qin JH, Sheng YY, Zhang ZM, Shi YZ, He P, Hu BY, Yang Y,Liu SG, Zhao GP, Guo XK. Genome-wide transcriptional analysis of temperature shiftinL. interrogansserovarlai strain 56601.BMC Microbiol. 2006 Jun9;6:51.
Li ZH, Dong K, Yuan JP, Hu BY, Liu JX, Zhao GP, Guo XK. Characterization of the cheY genes from Leptospira interrogans and their effects on the behavior of Escherichia coli. Biochem Biophys Res Commun. 2006; 345(2):858-866.
Guo XK, Zhao WQ, Kondo C, Shimojo N, Yamashita K, Aoki T, Hayakawa T. Tissue inhibitors of metalloproteinases-1 (TIMP-1) and-2(TIMP-2) are major serum factors that stimulate the TIMP-1 gene in human gingival fibroblasts. Biochim Biophys Acta. 2006; 1763(3):296-304.
Li ZH, Dong K, Sun JC, Yuan JP, Hu BY, Liu JX, Zhao GP,Guo XK. Characterization of cheW genes of Leptospirainterrogansand their effects in Escherichia coli.Acta Biochim Biophys Sin. 2006; 38(2):79-88.
Yang HL, Jiang XC, Zhang XY, Li WJ, Hu BY, Zhao GP, Guo XK. Thrombocytopenia in the experimental leptospirosis ofguinea pig is not related to disseminated intravascular coagulation.BMC Infect Dis. 2006 Feb 2;6:19.
Zhang XY, Yu Y, He P, Zhang YX, Hu BY, Yang Y, NieYX,Jiang XG, Zhao GP, Guo XK. Expression and comparative analysis of genes encoding outer membrane proteins LipL21, LipL32 and OmpL1 in epidemic leptospires. Acta Biochim Biophys Sin. 2005; 37(10):649-656.
Zhang YX, Geng Y, Bi B, He JY, Wu CF, Guo XK, Zhao GP. Identification and classification of all potential hemolysin encoding genes and their products from Leptospira interrogans serogroup Icterohae-morrhagiae serovar Lai. Acta Pharmacol Sin. 2005; 26(4): 453-461.
Wang HT, Li ZH, Yuan JP, Zhao W, Shi XD, Tong SQ, Guo XK. Effect of Helicobacter pylori VacA on gene expression of gastric cancer cells. World J Gastroenterol. 2005; 11(1):109-13.
Yuan JP, Li T, Chen HB, Li ZH, Yang GZ, Hu BY, Shi XD,Tong SQ, Li YX, Guo XK. Analysis of gene expression profile in gastric cancercells stimulated with Helicobacter pylori isogenic strains. J Med Microbiol. 2004; 53(Pt 10):965-974.
. Li ZH, Nie BM, Chen H, Chen SY, He P, Lu Y,Guo XK, Liu JX. In vitro anti-coxsackie virusB(3) effect of ethyl acetateextract of Tian-hua-fen. World J Gastroenterol. 2004; 10(15):2263-6.
Zhang YX, Guo XK, Wu C, Bi B, Ren SX, Wu CF, ZhaoGP. Characterization of a novel toxin-antitoxin module,VapBC, encoded by Leptospira interrogans chromosome. Cell Res. 2004; 14(3):208-216.
Yuan JP, Li T, Li ZH, Yang GZ, Hu BY, Shi XD, Shi TL,Tong SQ, Guo XK.mRNA expression profiling reveals a role of Helicobacter pylori vacuolating toxin in escaping host defense. World J Gastroenterol. 2004; 10(10):1528-1532.
He P,Zhang XY, Guo XK, Hu BY, Huang XT,Yang Y, Zhao GP. Identification and analysis of genes present in Leptospira interrogans serovar Lai but absent in L. biflexa serovar monvalerio. Acta Biochim Biophysica Sin, 2004, 36(12):832-839.
XuH,Zhang Y, Guo XK, Ren S, StaempfliAA, Chiao J, Jiang W, Zhao G. Isoleucine biosynthesis in Leptospirainterrogans serotype lai strain 56601 proceeds via a threonine-independent pathway. J. Bacteriol, 2004, 186(16): 5400-5409.
Yuan JP, Li T, Shi XD, Hu BY, Yang GZ, Tong SQ, Guo XK. Deletion of Helicobacter pylori vacuolating cytotoxingene by introduction of directed mutagenesis.World J Gastroenterol.2003; 9(10):2251-7.
Yuan JP, Zhao W, Wang HT, Wu KY, Li T, Guo XK, Tong SQ. Coxsackie virus B3-induced apoptosis and caspase-3.Cell Res. 2003; 13(3):203- 209.
Ren SX, Fu G, Jiang XG, Zeng R, Miao YG, Xu H, ZhangYX, Xiong H, Lu G, Lu LF, Jiang HQ, Jia J, Tu YF, Jiang JX, Gu WY, Zhang YQ,Cai Z, Sheng HH, Yin HF, Zhang Y, Zhu GF, Wan M, Huang HL, Qian Z, Wang SY, MaW, Yao ZJ, Shen Y, Qiang BQ, Xia QC, Guo XK, Danchin A, Saint GironsI,Somerville RL, Wen YM, Shi MH, Chen Z, Xu JG, Zhao GP.Unique physiological and pathogenicfeatures of Leptospira interrogans revealed by whole-genome sequencing. Nature. 2003; 422(6934):888-893.
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