标题：醋酸铅
基本信息
中文名称:四乙酸铅 
中文别名:醋酸高铅;乙酸高铅盐;醋酸铅;四醋酸铅;乙酸高铅;乙酸铅(Ⅳ);四醋酸铅;铅糖、乙酸铅;;乙酸铅(IV)[1]
英文名称:Lead(IV) acetate
英文别名:Lead tetraacetate; LTA; Lead(IV) acetate (5-10% acetic acid); Leadacetateaceticacidwhitetolightbrownxtl; LEAD TETRACETATE; Lead (II) acetate; acetate, lead(2+) salt (4:1)
中文别名：乙酸铅、铅糖[2]
英文名称：lead acetate，plumbous acetate，sugar of lead（铅糖）[3]
化学式：(CH3COO)2Pb，Pb（Ac）2
式量：325
CAS号（三水醋酸铅）：6080-56-4[4]
EINECS号（三水醋酸铅）：206-104-4[5]
InChI（三水醋酸铅）：InChI=1/2C2H4O2.3H2O.Pb/c2*1-2(3)4;;;;/h2*1H3,(H,3,4);3*1H2;/q;;;;;+2/p-2[6]
物化性质
  醋酸铅三水醋酸铅白色单斜晶体，密度2.55g·cm-3（25℃）。熔点75℃（急热）。可燃。略带乙酸气味。具有风化性。折射率1.567。弱电解质。易溶于水，溶解度55.04g/100g水。也溶于丙三醇，不溶于乙醚。75℃时失水成无水醋酸铅。[2-3]十水醋酸铅白色正交晶体，密度1.69g·cm-3（25℃）。常温下容易风化失水。弱电解质。易溶于水，溶于丙三醇，不溶于乙醚。[2]无水醋酸铅白色粉末，密度3.75g·cm-3（20℃）。熔点280&ordm;C。弱电解质。易溶于水，溶解度44.3g/100g水。不溶于乙醚。[2-3]
制备方法
由一氧化铅与乙酸进行复分解反应制取：  醋酸铅[2]
PbO+2CH3COOH=(CH3COO)2Pb+H2O.
用途
用于制备各种铅盐（硼酸铅、硬脂酸铅等）、抗污涂料（醋酸铅与重铬酸钾作用可制取铬黄）、水质防护剂、颜料填充剂、涂料干燥剂、纤维染色剂以及重金属氰化过程的溶剂。
在纺织工业中，用做蓬帆布配制铅皂防水的原料。在电镀工业中，是氰化镀铜的发光剂。在化学分析中用作测定三氧化铬、三氧化钼的试剂。醋酸铅也是皮毛行业染色助剂。
另外，将1g醋酸铅溶于20ml去离子水，把5mm×30mm的滤纸条浸到醋酸铅溶液中，即成乙酸铅试纸（CAS号301-04-2）。该试纸遇硫化氢气体，或沾上含硫化物的酸性溶液即变黑色，验证有硫化氢或硫化物存在。[2]
计算化学数据
1、疏水参数计算参考值（XlogP）：
2、氢键供体数量：3
3、氢键受体数量：7
4、可旋转化学键数量：0
5、互变异构体数量：
6、拓扑分子极性表面积（TPSA）：55.6
7、重原子数量：12
8、表面电荷：0
9、复杂度：108
10、同位素原子数量：0
11、确定原子立构中心数量：0
12、不确定原子立构中心数量：0
13、确定化学键立构中心数量：0
14、不确定化学键立构中心数量：0
15、共价键单元数量：4[5]
对环境的影响
健康危害侵入途径：吸入、食入、经皮吸收。 
健康危害：损害造血、神经、消化系统及肾脏。职业中毒主要为慢性。神经系统主要表现为神经衰弱综合征、周围神经病（以运动功能受累较明显），重者出现铅中毒性脑病。消化系统表现为齿龈铅线、食欲不振、恶心、腹胀、腹泻或便秘；腹绞痛见于中等及较重病例。造血系统损害出现卟啉代谢障碍、贫血等。短时大量接触可发生急性或亚急性铅中毒，表现类似重症慢性铅中毒。本品可经皮肤吸收，可致灼伤；对眼有刺激性。 毒理学资料及环境行为急性毒性：LD50174mg/kg(小鼠静注) 。
致癌性：按RTECS标准为可疑致肿瘤物。 
危险特性：遇明火、高热可燃。受高热分解放出有毒的气体。 
燃烧(分解)产物：一氧化碳、二氧化碳、氧化铅。
环境标准
中国(TJ36-79)：车间空气中有害物质的最高容许浓度 0.05mg/m3 
前苏联(1975)：水体中有害物质最高允许浓度 5mg/L(乙酸盐) 
日本：对工业污水中使鱼类致死的有毒物浓度的规定 0.7～11.3ppm(致死浓度)
应急处理处置方法
泄漏应急处理隔离泄漏污染区，周围设警告标志，建议应急处理人员戴好防毒面具，穿化学防护服。不要直接接触泄漏物，避免扬尘，收集于干燥净洁有盖的容器，运至废物处理场所。也可以用大量水冲洗，经稀释的洗水放入废水系统。如大量泄漏，收集回收或无害处理后废弃。 防护措施呼吸系统防护：作业工人应该佩带防尘口罩。必要时佩带防毒面具。 
眼睛防护：必要时戴安全防护眼镜。 
防护服：穿相应的防护服。 
手防护：戴防护手套。 
其它：工作现场禁止吸烟、进食和饮水。工作淋浴更衣。单独存放被毒物污染的衣服以，洗后再用。进行就业前和定期的体检。 急救措施皮肤接触：脱去污染的衣着，用肥皂水及清水彻底冲洗。 
眼睛接触：立即提起眼睑，用大量流动清水或生理盐水冲洗。 
吸入：脱离现场至空气新鲜处。必要时进行人工呼吸。就医。 
食入：误服者给饮大量温水，催吐，用清水或硫代硫酸钠溶液洗胃。给饮牛奶或蛋清。就医。 
灭火方法：雾状水、泡沫、二氧化碳、砂土。
安全信息
危险品标志  NN：环境危险物质
  T
T：有毒物质[4]安全说明S45：若发生事故或感不适，立即就医(可能的话，出示其标签)。
S53：避免接触，使用前须获得特别指示说明。
S60：该物质及其容器须作为危险性废料处置。
S61：避免释放至环境中。参考特别说明/安全数据说明书。[6-7]危险类别码R33：有累积效应的危险品。
R48/22：吞食长期接触严重危害健康。
R50/53：对水生生物有极高毒性，可能对水体环境产生长期不良影响。
R61：可能对胎儿造成伤害。
R62：有损害生育能力的危险。[6-7]
醋酸铅与罗马的灭亡
公元前2世纪，繁荣的希腊，由于不明的原因使统治集团体弱力衰，被强盛的罗马帝国征服，并于公元前146年并入罗马版图。随着希腊先进酿酒及烹饪技术的引入，一种新奇的金属制品也成为罗马贵族阶层的日用珍贵器具。 
它制作的器皿，光亮闪烁，不像铜器那样产生令人讨厌的绿锈。贵族们爱喝的葡萄汁中若加上这种金属粉，可以除掉酸味，还可使酒醇香而甜；有轻泻作用的蜂蜜在这种金属容器中加热，成了止泻剂；这种金属粉制成的化妆品，可让贵族夫人们的皮肤更白……这种金属就是铅。 
现代研究表明，葡萄酒不发酸，是由于生成了带甜味的醋酸铅，而且铅能杀死发酵的微生物；加热蜂蜜止泻是因为溶出的铅抑制消化道的运动，是一种毒性反应。铅是多亲和性毒物，它对人的全身各个系统都有毒性，除消化系统外，还严重影响到生殖系统、神经系统等。并且铅的致毒剂量很低，每日摄入1毫克即危险，同时难于排解。 
铅中毒后不仅有失眠、头痛、乏力等体质消退和不适应症状，还将导致男性不育、妇女不孕。即使怀孕也会发生流产、死胎；少数胎儿虽能成活，由于铅对神经系统的毒性，大都造成永久性的智力低下。这样，铅毒在充分享用当时铅文明的贵族中像瘟疫一样蔓延。据记载，古罗马特洛伊贵族35名结了婚的王爷，半数以上没有生育；其余的王妃虽然有喜，活着生下的只是少数几个低能儿，皇室几乎没有嫡生的子女。为此，安东宁斯皇帝提出了一项补救措施，选拔贵族中健康而又聪明的人为皇位继承人。这本是一项希腊早期贵族共和制的明智决策；可惜当皇位传到马康斯奥里利斯时，皇后生了一个白痴康美大斯，而昏庸的皇上让他继承了王位。从此破坏了选拔制度，统治集团的衰落，最终使罗马帝国灭亡。 
2000多年后，在考古学、毒理学、环境化学、古尸分析法检的基础上，解开了生活中铅性食品和用具给古罗马宫廷带来的灾难之谜。
物质毒性
编号
毒性类型
测试方法
测试对象
使用剂量
毒性作用
1
acute 
Oral 
Human 
714 mg/kg 
1.大脑毒性Brain and Coverings - other degenerative changes2.行为毒性Behavioral - convulsions or effect on seizure threshold3.胃肠道毒性Gastrointestinal - nausea or vomiting
2
acute 
Intravenous 
Human - man 
71 mg/kg 
1.肝毒性Liver - hepatitis (hepatocellular necrosis), diffuse2.血液毒性Blood - normocytic anemia3.生化毒性Biochemical - Metabolism (Intermediary) - other
3
acute 
Intraperitoneal 
Rodent - rat 
150 mg/kg 
1.Details of toxic effects not reported other than lethal dose value
4
acute 
Intraperitoneal 
Rodent - mouse 
140 mg/kg 
1.Details of toxic effects not reported other than lethal dose value
5
acute 
Intravenous 
Rodent - mouse 
104 mg/kg 
1.营养和代谢系统毒性Nutritional and Gross Metabolic - weight loss or decreased weight gain
6
acute 
Oral 
Mammal - dog 
300 mg/kg 
1.Details of toxic effects not reported other than lethal dose value
7
acute 
Subcutaneous 
Mammal - dog 
80 mg/kg 
1.Details of toxic effects not reported other than lethal dose value
8
acute 
Intravenous 
Mammal - dog 
300 mg/kg 
1.Details of toxic effects not reported other than lethal dose value
9
acute 
Subcutaneous 
Mammal - cat 
100 mg/kg 
1.Details of toxic effects not reported other than lethal dose value
10
acute 
Subcutaneous 
Rodent - rabbit 
300 mg/kg 
1.Details of toxic effects not reported other than lethal dose value
11
acute 
Intravenous 
Rodent - rabbit 
25 mg/kg 
1.行为毒性Behavioral - convulsions or effect on seizure threshold2.行为毒性Behavioral - food intake (animal)3.胃肠道毒性Gastrointestinal - hypermotility, diarrhea
12
acute 
Intraperitoneal 
Bird - pigeon 
150 mg/kg 
1.Details of toxic effects not reported other than lethal dose value
13
acute 
Subcutaneous 
Amphibian - frog 
1600 mg/kg 
1.Details of toxic effects not reported other than lethal dose value
14
MutipleDose 
Oral 
Rodent - rat 
240 mg/kg/17W-I 
1.肝毒性Liver - other changes2.肾、输尿管和膀胱毒性Kidney, Ureter, Bladder - other changes3.生化毒性Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases
15
MutipleDose 
Oral 
Rodent - rat 
122 mg/kg/90D-C 
1.心脏毒性Cardiac - EKG changes not diagnostic of specified effects2.血管毒性Vascular - BP elevation not characterized in autonomic section3.营养和代谢系统毒性Nutritional and Gross Metabolic - changes in calcium
16
MutipleDose 
Oral 
Rodent - rat 
2006 mg/kg/61W-C 
1.大脑毒性Brain and Coverings - other degenerative changes2.血管毒性Vascular - BP elevation not characterized in autonomic section3.营养和代谢系统毒性Nutritional and Gross Metabolic - changes in metals, not otherwise specified
17
MutipleDose 
Oral 
Rodent - rat 
43 mg/kg/1.5Y-C 
1.肾、输尿管和膀胱毒性Kidney, Ureter, Bladder - other changes2.血液毒性Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
18
MutipleDose 
Oral 
Rodent - rat 
923 mg/kg/28W-C 
1.周围神经毒性Peripheral Nerve and Sensation - sensory change involving peripheral nerve2.周围神经毒性Peripheral Nerve and Sensation - recording from peripheral motor nerve3.营养和代谢系统毒性Nutritional and Gross Metabolic - weight loss or decreased weight gain
19
MutipleDose 
Oral 
Rodent - rat 
192 mg/kg/5W-C 
1.血液毒性Blood - changes in erythrocyte (RBC) count2.营养和代谢系统毒性Nutritional and Gross Metabolic - weight loss or decreased weight gain3.生化毒性Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
20
MutipleDose 
Oral 
Rodent - rat 
126 mg/kg/30W-C 
1.肾、输尿管和膀胱毒性Kidney, Ureter, Bladder - changes in bladder weight2.内分泌毒性Endocrine - hypoglycemia
21
MutipleDose 
Oral 
Rodent - rat 
344 mg/kg/1Y-C 
1.大脑毒性Brain and Coverings - other degenerative changes2.大脑毒性Brain and Coverings - changes in brain weight3.营养和代谢系统毒性Nutritional and Gross Metabolic - weight loss or decreased weight gain
22
MutipleDose 
Oral 
Rodent - rat 
2907 mg/kg/36W-C 
1.肾、输尿管和膀胱毒性Kidney, Ureter, Bladder - other changes2.肾、输尿管和膀胱毒性Kidney, Ureter, Bladder - changes in bladder weight3.内分泌毒性Endocrine - changes in spleen weight
23
MutipleDose 
Intraperitoneal 
Rodent - rat 
59 mg/kg/6W-I 
1.胃肠道毒性Gastrointestinal - other changes2.营养和代谢系统毒性Nutritional and Gross Metabolic - changes in sodium3.生化毒性Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
24
MutipleDose 
Oral 
Rodent - rat 
4404 mg/kg/8W-I 
1.大脑毒性Brain and Coverings - other degenerative changes2.生化毒性Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase3.生化毒性Biochemical - Metabolism (Intermediary) - lipids including transport
25
MutipleDose 
Subcutaneous 
Rodent - rat 
450 mg/kg/6W-I 
1.血液毒性Blood - normocytic anemia2.生化毒性Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other hydrolases3.生化毒性Biochemical - Metabolism (Intermediary) - porphyrin including bile pigments
26
MutipleDose 
Subcutaneous 
Rodent - rat 
1920 mg/kg/14W-I 
1.血液毒性Blood - pigmented or nucleated red blood cells2.血液毒性Blood - methemoglobinemia-carboxyhemoglobin3.血液毒性Blood - changes in erythrocyte (RBC) count
27
MutipleDose 
Intraperitoneal 
Rodent - rat 
30 mg/kg/30D-I 
1.血液毒性Blood - other changes2.营养和代谢系统毒性Nutritional and Gross Metabolic - weight loss or decreased weight gain3.慢性病相关毒性Related to Chronic Data - changes in testicular weight
28
MutipleDose 
Intraperitoneal 
Rodent - rat 
152 mg/kg/4D-I 
1.大脑毒性Brain and Coverings - changes in surface EEG2.血液毒性Blood - other changes3.营养和代谢系统毒性Nutritional and Gross Metabolic - weight loss or decreased weight gain
29
MutipleDose 
Intraperitoneal 
Rodent - rat 
69 mg/kg/22W-I 
1.周围神经毒性Peripheral Nerve and Sensation - recording from afferent nerve2.周围神经毒性Peripheral Nerve and Sensation - recording from peripheral motor nerve3.肾、输尿管和膀胱毒性Kidney, Ureter, Bladder - other changes in urine composition
30
MutipleDose 
Oral 
Rodent - mouse 
1120 mg/kg/16W-I 
1.大脑毒性Brain and Coverings - other degenerative changes2.大脑毒性Brain and Coverings - changes in brain weight3.生化毒性Biochemical - Metabolism (Intermediary) - other proteins
31
MutipleDose 
Oral 
Rodent - mouse 
880 mg/kg/14D-C 
1.肾、输尿管和膀胱毒性Kidney, Ureter, Bladder - other changes in urine composition2.生化毒性Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other hydrolases3.生化毒性Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes
32
MutipleDose 
Oral 
Rodent - mouse 
11087 mg/kg/26W-C 
1.血液毒性Blood - other changes2.生化毒性Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes
33
MutipleDose 
Oral 
Rodent - mouse 
4710 mg/kg/30D-C 
1.血液毒性Blood - other changes2.血液毒性Blood - changes in bone marrow (not otherwise specified)3.生化毒性Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other hydrolases
34
MutipleDose 
Intraperitoneal 
Rodent - mouse 
37680 ug/kg/5D-I 
1.肾、输尿管和膀胱毒性Kidney, Ureter, Bladder - other changes2.血液毒性Blood - other changes3.营养和代谢系统毒性Nutritional and Gross Metabolic - changes in metals, not otherwise specified
35
MutipleDose 
Oral 
Mammal - dog 
286 mg/kg/13W-I 
1.肾、输尿管和膀胱毒性Kidney, Ureter, Bladder - other changes in urine composition2.血液毒性Blood - other changes3.生化毒性Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes
36
MutipleDose 
Subcutaneous 
Rodent - rabbit 
117 mg/kg/33W-I 
1.血液毒性Blood - normocytic anemia2.血液毒性Blood - other changes
37
MutipleDose 
Oral 
Bird - pigeon 
4396 mg/kg/64W-I 
1.肾、输尿管和膀胱毒性Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)2.血液毒性Blood - normocytic anemia3.血液毒性Blood - other changes
38
MutipleDose 
Oral 
Mammal - domestic 
105 mg/kg/7D-I 
1.大脑毒性Brain and Coverings - recordings from specific areas of CNS2.眼毒性Sense Organs and Special Senses (Eye) - effect, not otherwise specified3.生化毒性Biochemical - Metabolism (Intermediary) - glycolytic
39
Mutation 
Bacteria - Escherichia coli 
50 umol/L 
40
Mutation 
Yeast - Saccharomyces cerevisiae 
250 umol/L 
41
Mutation 
Human Lymphocyte 
1 mmol/L/24H 
42
Mutation 
Intraperitoneal 
Rodent - rat 
51800 ug/kg 
43
Mutation 
Rodent - rat Embryo 
200 mg/L 
44
Mutation 
Intraperitoneal 
Rodent - rat 
50 ug/kg 
45
Mutation 
Parenteral 
Rodent - rat 
5 mg/kg 
46
Mutation 
Intraperitoneal 
Rodent - rat 
10400 ug/kg 
47
Mutation 
Oral 
Rodent - rat 
5000 ppm 
48
Mutation 
Unreported 
Rodent - rat 
9 mg/kg/26W (Continuous) 
49
Mutation 
Intraperitoneal 
Rodent - rat 
51800 ug/kg 
50
Mutation 
Unreported 
Rodent - rat 
1825 ug/kg/1Y (Continuous) 
51
Mutation 
Intraperitoneal 
Rodent - mouse 
7500 ug/kg 
52
Mutation 
Rodent - mouse Fibroblast 
800 ug/L 
53
Mutation 
Oral 
Rodent - mouse 
16800 mg/kg/4W 
54
Mutation 
Intraperitoneal 
Rodent - mouse 
100 mg/kg 
55
Mutation 
Oral 
Rodent - mouse 
19200 mg/kg/48D 
56
Mutation 
Intraperitoneal 
Rodent - mouse 
179 ug/kg 
57
Mutation 
Parenteral 
Rodent - mouse 
1 mg/kg 
58
Mutation 
Intraperitoneal 
Rodent - mouse 
400 mg/kg/5D (Intermittent) 
59
Mutation 
Rodent - hamster Embryo 
1 mg/L 
60
Mutation 
Rodent - hamster Lung 
1700 umol/L 
61
Mutation 
Rodent - hamster Embryo 
200 umol/L 
62
Mutation 
Rodent - hamster Lung 
1700 umol/L 
63
Mutation 
Oral 
Primate - monkey 
206 mg/kg/64W (Intermittent) 
64
Mutation 
Oral 
Mammal - domestic 
364 mg/kg/52W (Continuous) 
65
Mutation 
Intratesticular 
Mammal - domestic 
10 mg/kg 
66
Tumorigenic 
Oral 
Rodent - rat 
900 mg/kg/60D-C 
1.致癌性Tumorigenic - neoplastic by RTECS criteria2.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - tumors3.内分泌毒性Endocrine - adrenal cortex tumors
67
Tumorigenic 
Oral 
Rodent - rat 
250 mg/kg/47W-C 
1.致癌性Tumorigenic - equivocal tumorigenic agent by RTECS criteria2.肾、输尿管和膀胱毒性Kidney, Ureter, Bladder - Kidney tumors
68
Tumorigenic 
Oral 
Rodent - rat 
2430 mg/kg/23W-C 
1.致癌性Tumorigenic - equivocal tumorigenic agent by RTECS criteria2.大脑毒性Brain and Coverings - tumors3.内分泌毒性Endocrine - tumors
69
Tumorigenic 
Oral 
Rodent - rat 
4605 mg/kg/44W-C 
1.致癌性Tumorigenic - equivocal tumorigenic agent by RTECS criteria2.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - tumors3.内分泌毒性Endocrine - adrenal cortex tumors
70
Tumorigenic 
Oral 
Rodent - rat 
7560 mg/kg/72W-C 
1.致癌性Tumorigenic - neoplastic by RTECS criteria2.内分泌毒性Endocrine - tumors3.内分泌毒性Endocrine - thyroid tumors
71
Tumorigenic 
Oral 
Rodent - rat 
9150 mg/kg/44W-C 
1.致癌性Tumorigenic - neoplastic by RTECS criteria2.肾、输尿管和膀胱毒性Kidney, Ureter, Bladder - Kidney tumors
72
Tumorigenic 
Oral 
Rodent - rat 
218 mg/kg/1Y-C 
1.致癌性Tumorigenic - equivocal tumorigenic agent by RTECS criteria2.肾、输尿管和膀胱毒性Kidney, Ureter, Bladder - Kidney tumors
73
Tumorigenic 
Oral 
Rodent - rat 
138 mg/kg/76W-C 
1.致癌性Tumorigenic - equivocal tumorigenic agent by RTECS criteria2.肾、输尿管和膀胱毒性Kidney, Ureter, Bladder - Kidney tumors
74
Reproductive 
Oral 
Rodent - rat 
1257 uL/kg,female 10 day(s) pre-mating 
1.生殖毒性Reproductive - Maternal Effects - other effects2.生殖毒性Reproductive - Specific Developmental Abnormalities - blood and lymphatic systems (including spleen and marrow)3.生殖毒性Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
75
Reproductive 
Oral 
Rodent - rat 
600 ug/kg,male 30 day(s) pre-mating 
1.生殖毒性Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)2.生殖毒性Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands3.生殖毒性Reproductive - Paternal Effects - impotence
76
Reproductive 
Oral 
Rodent - rat 
97 mg/kg,male 5 week(s) pre-mating 
1.生殖毒性Reproductive - Effects on Newborn - behavioral
77
Reproductive 
Oral 
Rodent - rat 
14700 mg/kg,female 1-21 day(s) after conception 
1.生殖毒性Reproductive - Effects on Newborn - live birth index (measured after birth)2.生殖毒性Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)3.生殖毒性Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
78
Reproductive 
Oral 
Rodent - rat 
1800 mg/kg,female 1-22 day(s) after conception 
1.生殖毒性Reproductive - Effects on Newborn - biochemical and metabolic
79
Reproductive 
Oral 
Rodent - rat 
460 mg/kg,female 49 day(s) pre-mating - 21 day(s) 
1.生殖毒性Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
80
Reproductive 
Oral 
Rodent - rat 
230 mg/kg,female 49 day(s) pre-mating - 21 day(s) 
1.生殖毒性Reproductive - Specific Developmental Abnormalities - blood and lymphatic systems (including spleen and marrow)2.生殖毒性Reproductive - Effects on Newborn - other postnatal measures or effects
81
Reproductive 
Oral 
Rodent - rat 
1950 mg/kg,female 6-18 day(s) after conception 
1.生殖毒性Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
82
Reproductive 
Oral 
Rodent - rat 
1413 mg/kg,female 1-18 day(s) after conception 
1.生殖毒性Reproductive - Effects on Embryo or Fetus - maternal-fetal exchange2.生殖毒性Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
83
Reproductive 
Intraperitoneal 
Rodent - rat 
25 mg/kg,female 9 day(s) after conception 
1.生殖毒性Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)2.生殖毒性Reproductive - Effects on Embryo or Fetus - fetal death3.生殖毒性Reproductive - Specific Developmental Abnormalities - eye/ear
84
Reproductive 
Intraperitoneal 
Rodent - rat 
120 mg/kg,male 30 day(s) pre-mating 
1.生殖毒性Reproductive - Paternal Effects - testes, epididymis, sperm duct2.生殖毒性Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
85
Reproductive 
Intraperitoneal 
Rodent - rat 
60 mg/kg,female 13-19 day(s) after conception 
1.生殖毒性Reproductive - Effects on Embryo or Fetus - other effects to embryo
86
Reproductive 
Intraperitoneal 
Rodent - rat 
1256 mg/kg,male 14 week(s) pre-mating 
1.生殖毒性Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)2.生殖毒性Reproductive - Paternal Effects - testes, epididymis, sperm duct
87
Reproductive 
Oral 
Rodent - rat 
2380 mg/kg,male 17 week(s) pre-mating 
1.生殖毒性Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)2.生殖毒性Reproductive - Effects on Newborn - delayed effects
88
Reproductive 
Oral 
Rodent - mouse 
236 mg/kg,female 7-16 day(s) after conception 
1.生殖毒性Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
89
Reproductive 
Oral 
Rodent - mouse 
4800 mg/kg,female 1-8 day(s) after conception 
1.生殖毒性Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
90
Reproductive 
Oral 
Rodent - mouse 
9 mg/kg,female 7-21 day(s) after conception 
1.生殖毒性Reproductive - Fertility - abortion
91
Reproductive 
Oral 
Rodent - mouse 
259 mg/kg,female 7-17 day(s) after conception 
1.生殖毒性Reproductive - Specific Developmental Abnormalities - blood and lymphatic systems (including spleen and marrow)
92
Reproductive 
Intraperitoneal 
Rodent - mouse 
35 mg/kg,female 8 day(s) after conception 
1.生殖毒性Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)2.生殖毒性Reproductive - Effects on Embryo or Fetus - fetal death3.生殖毒性Reproductive - Specific Developmental Abnormalities - musculoskeletal system
93
Reproductive 
Intraperitoneal 
Rodent - mouse 
180 mg/kg,female 10-16 day(s) after conception 
1.生殖毒性Reproductive - Specific Developmental Abnormalities - eye/ear2.生殖毒性Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)3.生殖毒性Reproductive - Effects on Newborn - behavioral
94
Reproductive 
Intravenous 
Rodent - mouse 
100 mg/kg,female 11 day(s) after conception 
1.生殖毒性Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)2.生殖毒性Reproductive - Effects on Embryo or Fetus - fetal death3.生殖毒性Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
95
Reproductive 
Intravenous 
Rodent - mouse 
200 mg/kg,female 7-8 day(s) after conception 
1.生殖毒性Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
96
Reproductive 
Oral 
Primate - monkey 
765 mg/kg,female 90 day(s) pre-mating 
1.生殖毒性Reproductive - Effects on Newborn - behavioral
97
Reproductive 
Oral 
Primate - monkey 
1557 mg/kg,female 62 week(s) pre-mating 
1.生殖毒性Reproductive - Maternal Effects - menstrual cycle changes or disorders
98
Reproductive 
Oral 
Primate - monkey 
600 mg/kg,female 57 week(s) pre-mating 
1.生殖毒性Reproductive - Maternal Effects - other effects2.内分泌毒性Endocrine - changes in luteinizing hormone
99
Reproductive 
Subcutaneous 
Rodent - rat 
110 mg/kg,male 15 week(s) pre-mating 
1.生殖毒性Reproductive - Effects on Newborn - behavioral2.生殖毒性Reproductive - Effects on Newborn - other postnatal measures or effects
100
Reproductive 
Oral 
Rodent - guinea pig 
300 mg/kg,female 22-52 day(s) after conception 
1.生殖毒性Reproductive - Maternal Effects - other effects2.生殖毒性Reproductive - Specific Developmental Abnormalities - Central Nervous System3.生殖毒性Reproductive - Specific Developmental Abnormalities - blood and lymphatic systems (including spleen and marrow)
101
Reproductive 
Oral 
Rodent - guinea pig 
1108 mg/kg,female 22-52 day(s) after conception 
1.生殖毒性Reproductive - Maternal Effects - other effects2.生殖毒性Reproductive - Specific Developmental Abnormalities - endocrine system
102
Reproductive 
Intraperitoneal 
Rodent - guinea pig 
12500 ug/kg,female 20 day(s) after conception 
1.生殖毒性Reproductive - Specific Developmental Abnormalities - Central Nervous System
103
Reproductive 
Intravenous 
Rodent - hamster 
50 mg/kg,female 8 day(s) after conception 
1.生殖毒性Reproductive - Specific Developmental Abnormalities - musculoskeletal system2.生殖毒性Reproductive - Specific Developmental Abnormalities - Central Nervous System3.生殖毒性Reproductive - Specific Developmental Abnormalities - eye/ear
104
Reproductive 
Intravenous 
Rodent - hamster 
25 mg/kg,female 8 day(s) after conception 
1.生殖毒性Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)2.生殖毒性Reproductive - Specific Developmental Abnormalities - musculoskeletal system
105
Reproductive 
Intratesticular 
Mammal - domestic 
10 mg/kg,male 1 day(s) pre-mating 
1.生殖毒性Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)2.生殖毒性Reproductive - Paternal Effects - testes, epididymis, sperm duct
106
Reproductive 
Intravenous 
Mammal - species unspecified 
256 mg/kg,female 7-10 day(s) after conception 
1.生殖毒性Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
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