标题：舒红兵
个人履历
简介舒红兵 中国科学院院士，教授 
专业： 细胞生物学、分子免疫学
研究方向： 细胞信号传导
2011年当选[1]为中国科学院院士，生命科学与医学学部
2012年当选[2]为发展中国家科学院院士，结构、细胞与分子生物学
2013年被推选[3]为全国政协委员（无党派界别）。
--------------------------------------------------------------------------------教育经历1983-1987 兰州大学生物学系动物学专业，学士
1987-1990 中国医学科学院基础医学研究所细胞生物学研究室，硕士 
1992-1995 美国Emory大学细胞及发育生物学项目，博士
1995-1997 美国Tularik公司David Goeddel实验室, 博士后
工作经历与任职
1990-1992 美国密西根大学医学中心，研究助理 
1997-1998 美国Magainin制药公司, 资深科学家
1998-2003 美国犹太医学及研究中心及科罗拉多大学健康科学中心免疫学系，助理教授 
2003-2005 美国犹太医学研究中心及科罗拉多大学健康科学中心免疫学系, 副教授
1999-2004 北京大学生命科学学院, 长江学者计划特聘教授
2005-现在 武汉大学生命科学学院，教授、院长
--------------------------------------------------------------------------------获奖及荣誉2006 中国科技部“感染与免疫的基础研究”973项目首席科学家
2005 中国教育部自然科学奖一等奖 (第一完成人)
2004 美国白细胞生物学学会Dolph Adams奖
2001 美国犹太医学及研究中心首届“杰出青年教授奖”
2001 美国Harmon基金会Harmon关节炎研究奖
2000 美国Ellison医学基金会新学者奖
1999 中国国家杰出青年基金获得者研究资助在美国工作期间以课题负责人身份获得美国NIH （3项R01），美国国防部，美国癌症协会，美国关节炎基金会等机构共10项、总经费600多万美元的资助。
回国工作后获得国家科技部973项目、863项目、国家自然基金重点项目、国家杰出青年基金等资助。研究成果已发表SCI论文50余篇，累计影响因子约460。已被SCI引用约4000次,其中被Science, Nature, Cell刊载论文引用100多次，单篇被他人引用超过100次的论文12篇。获得了两项美国授权专利。
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代表性论文
1.Shu HB, Agranoff A, Nabel EG, Leung K, Neish AS, Collins T, and Nabel GJ (1993). Differential regulation of VCAM-1 gene expression by specific NF-kB subunits in endothelial and epithelial cells. Mol. Cell. Biol. 13:6283-6289. 
2.Shu HB. and Joshi HC (1995). g-Tubulin can both neacleate microtubule assembly and self-assemble into tubular structures in mammalian cells. J. Cell Biol. 130: 1137-1147. 
3.Rothe M, Xiong J, Shu HB, Williamson K, Goddard A, Goeddel, DV (1996). I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction. Proc. Natl. Acad. Sci. USA. 93:8241-8246. 
4.Hsu H, Huang J, Shu HB, Baichwal VR, Goeddel, DV (1996). TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity 4:387-396. 
5.Hsu H, Shu HB, Pan MG, Goeddel DV (1996). TRADD-TRAF2 and TRADD-FADD interactionss define two distinct TNF receptor-1 signal transduction pathways. Cell 84:1-20. 
6.Shu HB, Takeuchi M, Goeddel DV (1996). The TNF receptor 2 signal transducers TRAF2 and c-IAP1 are components of the TNF receptor 1 signaling complex. Proc. Natl. Acad. Sci. USA. 93:13973-13978.
7.Shu HB, Halpins DR, Goeddel DV (1997). Casper is a FADD and Caspase-related Inducer of Apoptosis. Immunity 6:751-763. 
8.Yeh WC, Pompa JL, McCurrach ME, Shu HB, Elia AJ, Shahinian A, Ng M, Wajegam A, Mithchell K, El-Deiry WS, Lowe SW, Goeddel DV, Mak TW (1998). FADD: essential for embryonic development and signaling from some, but not all, inducers of apoptosis. Science 279:1954-1958. 
9.Shu HB*, Hu WH, Johnson H (1999). TALL-1 is a novel member of the TNF family that is downregulated by mitogens. J. Leukoc. Biol. 65:680-683. 
10. Hu WH, Johnson H, Shu HB* (1999). TRAIL signal NF-kB and JNK activation and apoptosis through distinct pathways. J. Biol. Chem. 274:30603-30610. 
11. Hu WH, Johnson H, Shu HB * (2000). Activation of NF-kB by FADD, Casper and Caspase-8. J. Biol. Chem. 275:10838-10844. 
12.Shu HB*, Johnson H (2000). BCMA is a receptor for the TNF family member TALL-1. Proc. Natl. Acad. Sci. USA. 97:9156-9161. 
13.Yeh WC, Itie A, Elia AJ, Ng M, Shu HB, Wakeham A, Mirtsos C, Suzuki N, Bonnard M, Goeddel DV, Mak TW (2000). Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development. Immunity 12:633-642. 
14.Chen D, Li X, Zhai Z, Shu HB* (2002) A novel zinc finger protein interacts with RIP and inhibits TNF- and IL-1-induced NF-kB activation. J. Biol. Chem. 277:15985-15991. 
15.Liu Y, Xu L, Opalka N, Kappler J, Shu HB, Zhang G (2002) Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands. Cell 108: 383-394. 
16.Wu M, Xu L, Li X, Zhai Z, Shu HB* (2002) AMID, an AIF homologous mitochondrion-associated protein, induces caspase-independent apoptosis. J. Biol. Chem. 277:25617-25623. 
17.Xu L, Wu M, Zhai Z, Shu HB* (2002) Identification of genes regulated by the tumor necrosis factor family member TALL-1. J. Leukoc. Biol. 72:410-416. 
18.Xu L, Shu HB* (2002) TRAF3 is associated with BAFF-R and negatively regulates BAFF-R-mediated NF-kB activation and IL10 production. J. Immunol. 169: 6883-6889. 
19.Liu Y, Hong X, Kappler J, Jiang L, Zhang R, Xu L, Pan CH, Martin WE, Murphy RC, Shu HB, Dai S, Zhang G (2003) Ligand-receptor binding revealed by the TNF family member TALL-1. Nature 423:49-56. 
20.Chen D, Xu LG, Chen L, Li L, Zhai Z, Shu HB* (2003). NIK is a component of the EGF/Heregulin receptor signaling complex. Oncogene, 22:4348-4355. 
21.Wu M, Xu L, Zhai Z, Shu HB* (2003) SINK: a p65-interacting protein that negatively regulates NF-kB-dependent transcription. J. Biol. Chem., 278:27072-27079. 
22.Bin L, Xu L, Shu HB* (2003) TIRP: a novel TIR domain-containing adapter protein involved in toll/interleukin-1 receptor signaling. J. Biol. Chem. 27:24526-24532. 
23.Bin L, Nielson L D, Liu X, Mason RJ, Shu HB* (2003) Identification of UGRP1 and MARCO as a lung-specific ligand-receptor pair. J. Immunol. 171:924-930. 
24.Zhang J, Xu LG, Han KJ, Shu HB* (2004) Identification of a ZU5 and death domain containing inhibitor of NF-kB. J. Biol. Chem. 279:17819-17825. 
25.Han KJ, Su X, Xu LG, Bin LH, Zhang J, Shu HB* (2004) Mechanisms of TRIF-induced ISRE and NF-kappa B activation and apoptosis pathways. J. Biol. Chem. 279:15652-15661. 
26.Huang J, Teng L, Li L, Liu T, Li L, Chen D, Xu LG, Zhai Z, Shu HB* (2004) ZNF216 is an A20-like and IKKgamma -interacting inhibitor of NF-kappa B activation. J. Biol. Chem. 279:16847-16853. 
27.Xu LG, Li LY, Shu HB* (2004) TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis. J. Biol. Chem. 279:17278-17282. 
28.Wu M, Xu LG, Su T, Huang J, Zhai Z, Shu HB* (2004) AMID is a p53-inducible gene down-regulated in tumors. Oncogene 23:6815-6819.
29.Lesley R, Xu Y, Kalled SL, Hess DM, Schwab SR, Shu HB, Cyster JG (2004) Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF. Immunity 20:441-453. 
30. Li L, Bin LH, Li F, Liu Y, Chen D, Zhai Z, Shu HB* (2005) TRIP6 is a RIP2-associated common signaling component of multiple NF-kB activation pathways. J. Cell Sci. 118:555-563. 
31.Mei J, Webb S, Zhang B, Shu HB* (2005) The p53-inducibel apoptotic proteinAMID is not required for development and tumor suppression. Oncogene 25:849-856. 
32.Xu LG, Wang YY, Han KJ, Li LY, Zhai Z, Shu HB* (2005) VISA is an adapter protein required for virus-triggered signaling. Molecular Cell 19:727-740. 
33.Huang J, Liu T, Chen D, Zhai Z, Shu HB* (2005) SIKE is an IKK-relative kinases-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways. EMBO J. 24: 4018-4028. 
34. Su X, Li S, Meng M, Qian W, Xie W, Chen D, Zhai Z, Shu HB* (2006) TRAF1 negatively regulates TRIF-mediated signaling. Eur. J. Immunol. 36:199-206. 
35.Zha J, Han K, Xu LG, Zhou Q, Chen D, Zhai Z, Shu HB* (2006). The Ret finger protein inhibits signaling mediated by the noncanonical and canonical IKK family members. J. Immunol. 176: 1072-1080. 
36.Zhong B, Tien P, Shu HB* (2006). Innate immune response: crosstalk of signaling and regulation of gene transcription. Virology 352:14-21. 
37.Tian Y, Zhang Y, Zhong B, Wang YY, Diao FC, Wang RP, Zhang M, Chen DY, Zhai ZH, Shu HB* (2007) RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation. J. Biol. Chem. 282:16776-16782.
38.Diao F, Li S, Tian Y, Zhang M, Xu LG, Zhang Y, Wang RP, Chen D, Zhai Z, Zhong B, Tien P, Shu HB* (2007) Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase.Proc. Natl. Acad. Sci. USA. 104:11706-11711.
39.Zhang M, Tian Y, Wang RP, Gao D, Zhang Y, Diao FC, Chen DY, Zhai ZH, Shu HB* (2008) Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3. Cell Res. 18:1096-1014. 
40.Zhang B, Huang J, Li HL, Liu T, Wang YY, Waterman P, Mao AP, Xu LG, Zhai Z, Liu D, Marrack P, Shu HB* (2008) GIDE is a mitochondrial E3 ubiquitin ligase that induces apoptosis and slows growth. Cell Res. 18:900-910. 
41.Wang RP, Zhang M, Li Y, Diao FC, Chen D, Zhai Z, Shu HB* (2008) Differential regulation of IKK alpha-mediated activation of IRF3/7 by NIK. Mol Immunol. 45:1926-1934. 
42.Zhong B, Yang Y, Li S, Wang YY, Li Y, Diao F, Lei C, He X, Zhang L, Tien P, Shu HB* (2008). The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation. Immunity. 29:538-550. 
43.Zhong B, Zhang L, Lei Z, Li Y, Mao AP, Yang Y, Wang YY, Zhang XL, Shu HB* (2009). RNF5 negatively regulates virus-induced IRF3 activation via ubiquitination and degradation of MITA. Immunity 30:397-407. 
44. Li Y, Li C, Xue P, Zhong B, Mao AP, Ran Y, Chen H, Wang YY, Yang F, Shu HB* (2009) ISG56 is a negative feedback regulator of virus-triggered signaling and cellular antiviral response. Proc. Natl. Acad. Sci. USA. 106:7945-7950. 
45.Wang YY, Liu LJ, Zhong B, Liu TT, Li Y, Yang Y, Ran Y, Li S, Tien P, Shu HB* (2010) WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kB activation. Proc. Natl. Acad. Sci. USA. 107:815-820. 
46. Li S, Zheng H, Mao AP, Zhong B, Li Y, Liu Y, Gao Y, Ran Y, Tien P, Shu HB* (2010) Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6. J. Biol. Chem. 285:4291-4297. 
47.Mao AP, Li S, Zhong B, Li Y, Yan J, Li Q, Teng C, Shu HB* (2010) Virus-triggered ubiquitination of TRAF3/6 by cIAP1/2 is essential for induction of interferon-beta (IFN-beta) and cellular antiviral response. J. Biol. Chem. 285:9470-9476.
48.Han KJ, Yang Y, Xu LG, Shu HB* (2010) Analysis of a TIR-less splice variant of TRIF reveals an unexpected mechanism of TLR3-mediated signaling. J. Biol. Chem. 285:12543-12550. 
49.Chen R, Zhang L, Zhong B, Tan B, Liu Y, Shu HB* (2010) The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling. Cell Res. 20: 802-811. 
50.Zhong B, Zhang Y, Tan B, Liu TT, Wang YY, Shu HB* (2010) The E3 ubiquitin ligase RNF5 targets virus-induced signaling adaptor for ubiquitination and degradation. J Immunol. 184:6249-6255.[4]