标题：陈俐娟
个人简历
发表论文115 篇，SCI 收录论文95 篇，其中以第一作者/ 通讯作者在国际杂志上发表SCI 收录论文60 篇, 主要国际论文被他人在30 多种国际其它杂志上多次引用达237次.主要代表作发表在MassSpectrom Rev （IF:11.5 ），J Control Release(IF:5.69), ClinCancer Res （IF:6.25 ），J Med Chem （IF ：4.9 ），J Pharm ExpTherapy( IF:4.3), Inter J Cancer (IF:4.7), Proteomics (IF:4.6), J Mater Chem(IF:4.33), J Chromatogr A (IF:3.75) , Cell Physiol Biochem(IF:3.52), J MassSpectrom (IF:3.06 ）等杂志，申请专利19 项，授权1 项，承担国家自然科学基金课题3 项,863重点项目1项, 十五重大专项“天然活性产物分离分析关键技术”1 项，省级重点项目3项，2006 年入选“新世纪优秀人才支持计划”。[1]
任职
肿瘤生物研究室副主任，中国医药生物技术协会，纳米生物专业委员会理事；四川大学学报医学版编委[1]
研究方向
天然药物活性成分的大规模分离纯化及结构修饰· 新型缓释药物载体材料的研究 · 液相色谱与质谱技术在药物代谢及药物动力学中的研究 . 天然及小分子药物设计与开发。[1]
代表性论著
· Liu X-Y, Yang J-L, Chen L-J* , Wei Y-Q*. Areview of current applications of mass spectrometry for neuroproteomics inepilepsy: many technologies one goal. Mass Spec Rev. 2010 , 29:197-246. （IF=11.507 ）
· Luo Y-F, Zheng H, Chen L-J* , Li R ，He C-M ，Yang S-Y ，Ye X, Chen Z-Z ，Li Z-C ，Gao Y ，Han J ，He G ，Yang L ，Wei Y-Q. Discovery of(Z)-5-(4-Methoxybenzylidene) thiazolidine -2, 4-dione ，a Readily Available and OrallyActive Glitazone for the Treatment of Concanavalin A-induced Acute Liver Injuryof BALB/c Mice. J Med Chem. 2010, 53(1) ，273?C281. (IF=4.898)
· Hu J, Ye H-Y, Fu A-F, Chen X, Wang Y-S, ChenX-C, Ye X, Xiao W-J, Duan X-M, Wei Y-Q , Chen L-J*. . Deguelin-an inhibitor totumor lymphangiogenesis and lymphatic metastasis by down-regulation of vascularendothelial cell growth factor-D in lung tumor model. Inter J Cancer.2010,126(5),1282-1292 . （IF=4.734 ）
· Wang X-H, Zhou J-C, Wang Y-S, Zhu Z-Y, Lu Y,Wei Y-Q, Chen L-J*. A phase I clinical and pharmacokinetic study of paclitaxelliposome infused in non-small-cell lung cancer patients with malignant pleuraleffusions. Eur J Cancer. 2010,46(2),449-455 . （IF=4.475 ）
· Liang S-F, Fu A-F, Zhang Q, Tang M-H, Zhou J,Wei Y-Q, Chen L-J*. Honokiol inhibits HepG2 migration via downregulation ofIQGAP1 expression discovered by a quantitative pharmaceutical proteomicanalysis. Proteomics. 2010, 10(3) , 349-368 （IF=4.586 ）
· Peng X-D, Wu X-H, Chen L-J *, Wang Z-L, HuX-H, Song L-F, He C-M, Luo Y-F, Chen Z-Z, Jin K. Lin H-G, Li X-L, Wang Y-S, WeiY-Q. Inhibition of Phosphoinositide 3-Kinase Ameliorates Dextran SodiumSulfate-Induced Colitis in Mice. J Pharmacol Exp Ther. 2010,332 (1), 46-56. （IF=4.309 )
· Ye H-Y ，Zhong S-J ，Li Y-F ，Tang M-H ，Peng A-H ，Hu J ，Shi J ，He S-C ，Wu W-S ，Chen L-J *. Enrichment andisolation of barbigerone from Millettia pachycarpa Benth. using highspeedcounter-current chromatography and preparative HPLC. J Sep Sci , 2010,33, 1?C8.(IF=2.746)
· Chen X, Wang X-H , Wang Y-S, Yang L * , Hu J,Xiao W-J, Fu A-F, Cai L-L, Li X, Ye X , Liu Y-L, Wu W-S, Shao X-M, Mao Y-Q, WeiY-Q, Chen L-J * . Improved Tumor-Targeting Drug Delivery and TherapeuticEfficacy by Cationic Liposome Modified with Truncated bFGF Peptide. J ControlRelease, 2010, 145,17 ?C 25 (IF=5.69)
· Wang W-H, Fu A-F, Lan J-B, Gao Y, You J S *,Chen L-J*. Rational Design of Fluorescent Bioimaging Probes by ControllingAggregation Behavior of Squaraines: A Special Effect of Ionic Liquid Pendants.CHEM-EUR J , 2010 , 16 , 5129 ?C 5137 (IF=5.454)
· Xiao W-J, Chen L-J* , Chen X, Yang L, MaoY-Q, Zhao X, Wei Y-Q . . Co-delivery of Doxorubicin and plasmid by a novelFGFR-mediated cationic liposome. Int J Pharm ，2010, 393, 119?C126 . (IF=3.061 ）
· Zhong Z-H , Wei X ，Qi B-W ，Xiao W-J, Fu A-F, Chen X, Hu J,Cai L-L, Yang L, Mao Y-Q, Wei Y-Q, Chen L-J * . A Fusion vaccine containingLiposomal bFGF and monophosphoryl lipid A, protect mice against tumor pulmonarymetastasis. Int J Pharm ，2010. doi:10.1016/j.ijpharm.2010.07.053 （IF=3.061 ）
· Qi B-W ，Zhao Y-L ，Wei X ，Xiao W-J , Zheng H ，Chen Z-Z, Duan X-M, Lu Y ，Zhao X, Wei Y-Q, Chen L-J *. A further investigation concerningcorrelation between anti-fibrotic effect of liposomal quercetin and cytokinesin pulmonary fibrosis. Eur J Pharmacol ，2010, 10;642(1-3):134-9 . . （IF=2.787 ）
· Shi J, Xu G-B, Chen L-J* , Peng A-H, Peng M,Luo Y-F, Ye H-Y, Zhong S-J, He S-C, Li S-C. Preparative purification ofhonokiol derivatives by high-speed counter-current chromatography. J ChromatogrA ，2010,1217,3461?C3465 （IF=3.756 ）
· W ang X-H, Zheng H, Zhu Z-Y, Wei Y-Q, Ch enL-J *. Clinical pharmacokinetics of paclitaxel liposome with a new route ofadministration in human based on the analysis with ultra performance liquidchromatography. J Pharm Sci-US ，2010. DOI: 10.1002/jps.22169 (I F=2.996)
· L uo H-D, Peng M, Ye H-Y, Chen L-J * , PengA-H, Tang M-H, Zhang F, Shi J. Linear scale-up of four phenolic alkaloidsseparation from the roots of Menispermum dauricum using high-speedcounter-current chromatography. J Chromatogr B ，2010, . 878, 1929?C1933 （IF=2.5 ）
· Peng A-H, Ye H-Y, Shi J, HeS-C ，Zhong S-J ，Chen L-J*. Parameters optimizationin intermittent counter-current extraction (ICcE) and comparison of throughputbetween ICcE and common HSCCC. J Chromatogr A,2010, 1217, 5935?C5939 （IF=3.756 ）
· Wei X , Han J , Chen ZZ , Qi BW , Wang GC ,Ma YH , Zheng H , Luo YF , Wei YQ , Chen LJ . A phosphoinositide 3-kinase-gammainhibitor, AS605240 prevents bleomycin-induced pulmonary fibrosis in rats.Biochem Biophys Res Commun. 2010, 25;397(2):311-7.
· Weida Wang, Afu Fu, Jingsong You, Ge Gao,Jingbo Lan, * , Lijuan Chen, * Squaraine-based colorimetric and fluorescentsensors for Cu2 t -specific detection and fluorescence imaging in living cells.Tetrahedron, 2010, 66, 3695?C3701.
· Yinghua Ma, Xianhuo Wang, Xin wei, Liang Ma,Hao Zheng, Baowen Qi, Wei zhu, Youfu Luo, Lijuan Chen* , Yuquan Wei.(Z)-5-(4-methoxybenzylidene) thiazolidine-2, 4-dione ameliorates theadjuvant-induced arthritis via inhibiting the migration of macrophage anddown-regulating the cytokine mRNA expression. International Immunopharmacology.2010,In press.
· Xianhuo Wang, Linyu Deng, Xia Ye ，Minghai Tang ，Xiang Chen, Lulu Cai, Xia Zhao,Yuquan Wei , Lijuan Chen* . Truncated BFGF-Mediated Cationic LiposomalPaclitaxel for Tumor-Targeted Drug Delivery: Improved Pharmacokinetics andBiodistribution in Tumor-Bearing Mice. J Pharm Sci-US ，2010,In press.
· Wen J , Fu A-F ，Chen L-J * ，Xie X-J ，Yang G-L, Chen X-C ，Wang Y-S , Li J, Chen P, Tang M-H, Shao X-M ，Lu Y, Zhao X ，Wei Y-Q. Liposomal HonokiolInhibits VEGF-D-induced L ymphangiogenesis and Metastasis in Xenograft TumorModel. Inter J Cancer, 2009, 124 (11): 2709-2718. （IF=4.734 ，）
· Li Z-G, Zhao Y-L, Wu X-H, Ye H-Y, Peng A-H,Cao Z-X, Mao Y-Q, Zheng Y-Z, Jiang P-D, Zhao X, Chen L-J*, Wei Y-Q *.Barbigerone, a Natural Isoflavone, Induces Apoptosis in Murine Lung-CancerCells via the Mitochondrial Apoptotic Pathway. Cell Physiol Biochem.2009,2495-104. （IF=3.246 ）
· Ye H-Y, Ignatova S, Peng A-H, Chen L-J * ,Sutherland I. Optimising resolution for a preparative separation of Chineseherbal medicine using a surrogate model sample system. J Chromatogr A . 2009,1216 (26), 5101-5105. （IF=3.756 ）
· Zhou J, Liang S-F , Fang L, Chen L-J* , TangM-H, Xu Y-H, Fu A-F, Yang J-L, Wei Y-Q. Quantitative proteomic analysis ofHepG2 cells treated with quercetin suggests IQGAP1 involved inquercetin-induced regulation of cell proliferation and migration. Omics. 2009,13 (2), 93-103. （IF=3.167 ，他引1 次）
· Luo Y-F, Xu Y-B, Chen L-J *, Hu J, Peng C,Xie D-C, Shi J-Y, Huang W-C, Xu G-B, Peng M, Han J, Li R, Yang S-Y, Wei Y-Q.Semi-synthesis and anti-proliferative activity evaluation of novel analogues ofHonokiol. Bioorg Med Chem Lett. 2009, 19 (16), 4702-4705. （IF=2.531 ）
· Wang Z-L, Wu X-H, Song L-F, Wang Y-S, Hu X-H,Luo Y-F, Chen Z-Z, Jin K, Peng X-D, He C-M, Chen L-J * , Wei Y-Q *.Phosphoinositide 3-kinase c inhibitor ameliorates concanavalin A-inducedhepatic injury in mice. Biochem Bioph Res Co . 2009,4 ，569-574. （IF=2.648 ）
· Peng X-D , Dai L-L , Huang C-Q , He C-M ,Yang B , Chen L-J * . R elationship between anti-fibrotic effect of Panaxnotoginseng saponins and serum cytokines in rat hepatic fibrosis. Biochem BiophRes Co . 2009, 9;388(1):31-4. （IF=2.648 ）
· Ye X, Tang M-H, Chen L-J *, Peng A-H, Ma L,Ye H-Y. Rapid separation and identification of major constituents inPseudolarix kaempferi by ultraperformance liquid chromatography coupled withelectrospray and quadrupole time-of-flight tandem mass spectrometry. RapidCommun Mass Sp . 2009,23(24) : 3954-3962. （IF=2.772 ）
· Peng X-D, Dai L-L, Huang C-Q, He C-M, ChenL-J *. Correlation between anti-fibrotic effect of baicalin and serum cytokinesin rat hepatic fibrosis. World J Gastroentero ，2009, 15 (37), 4720-4725. （IF=2.081 ）
· Peng A-H, Ye H-Y, Li X, Chen L-J*.Preparative separation of capsaicin and dihydrocapsaicin from Capsicumfrutescens by high-speed counter-current chromatography. J Sep Sci . 2009, 32(17), 2967-2973. （IF=2.746 ）
· Zhang Y-Y, Chen X, Lan J-B, You J-S*, ChenL-J*. Synthesis and Biological Applications of Imidazolium-Based PolymerizedIonic Liquid as a Gene Delivery Vector. Chem Biol Drug Des. 2009 ,74 (3),282-288. （IF=2.375 ）
· Hou W- L , Li Y-F, Zhang Q, Wei X, Peng A-H,Chen L- J * ，Wei Y-Q .Triterpene Acids Isolated from Lagerstroemia speciosa Leaves as α-Glucosidase Inhibitors . PhytotherRes . 2009, 23 (5), 614-618. （IF=1.772 ）
· Peng X-D, Huang C-Q, Chen L-J* . CognitiveBehavioural Therapy and Reminiscence Techniques for the Treatment of Depressionin the Elderly: a systematic review. J Inter Med Res. 20 09, 37 (4), 975-982 . （IF=0.821 ）
· Liu X-Y, Yang J-L ，Chen L-J* ，Zhang Y, Yang M-L, Wu Y-Y, Li F-Q,Tang M-H, Liang S-F, Wei Y-Q. Comparative proteomics and correlated signalingnetwork of rat hippocampus in the pilocarpine model of temporal lobe epilepsy.Proteomics . 2008,8,582-603. （IF=4.586 ）
· Luo Y-F, Xu Y-B, Chen L-J* ，Luo, H-D, Peng, C, Fu J, Chen H-J,Peng A-H, Ye H-Y, Xie D-C, Fu A-F, Shi J-Y, Yang S-Y, Wei Y-Q. Preparativepurification of anti-tumor derivatives of honokiol by high-speedcounter-current chromatography. J Chromatogr A. 2008,1178 :160?C165. （IF=3.756 ）
· Ye H-Y, Ignatova S, Luo H-D, Li Y-F ，Peng A-H, Chen L-J* , IanSutherland*. Preparative separation of a erpenoid and alkaloids fromTripterygium wilfordii Hook. f using high performance counter-currentchromatography: comparison of various elution and operating strategies ，J Chromatogr A . 2008,1213:145?C153. （IF=3.756 ）
· Ye H-Y, Chen L-J* , Li Y-F ，Peng A-H, Fu A-F, Song H, TangM-H, Luo H-D, Luo Y-F, Xu Y-B, Shi J-Y, Wei Y-Q. Preparative isolation andpurification of three rotenoids and one isoflavone from the seeds of Millettiapachycarpa Benth by high-speed counter-current chromatography. J Chromatogr A .2008,1178: 101?C107. （IF=3.756 ）
· Wang G-T, Li L-L, Lan J-B, Chen L-J* , YouJ-S*. Biomimetic Crystallization of Calcium Carbon ate Spherules Controlled byHyperbranched Polyglycerols. J Mater Chem. 2008, 18, 2789?C2797 （IF=4.646 ）
· Peng A-H, Li R, Hu J, Chen L-J*, ,Zhao X ? ,Luo H-D, Ye H-Y, Yuan Y, Wei Y Q . Flow rate gradient high-speedcounter-current chromatography separation of five diterpenoids fromTripterygium wilfordii and scale-up J Chromatogr A . 2008, 1200: 129-135. （IF=3.756 ）
· Li R, Chen W, Shi J-Y, Chen L-J* , Chen Y-C,Ding L-S, Wei Y-Q. Discovery and synthesis of a new bis(thiourea)-Pd pincerguided by ESI-MS/MS. J Mass Spectrom. 2008, 43: 542-546. （IF=2.94 ）
· Yuan Y, Wang B-Q, Chen L-J* , Luo H-D, FisherD, Sutherland I A. How to realize the linear scale-up process for the rapidpurification using high-capacity high-speed counter-current chromatography. JChromatogr A . 2008, 1194: 192-198 （IF=3.756 ）
· Li R, Peng A-H, He C-M, Wang X-H, Shi J-Y,Chen L-J* , Wei Y-Q . Analysis of triptophenolide and its related compoundsfrom Tripterygium wilfordii Hook.f by electrospray ionization tandem massspectrometry. Int J Mass Spectrom. 2008, 278:38-49. （IF=2.445 ）
· Hou W- L, Yang G- L, Chen L- J*, Zhong Z- H,Jiang Q- Q, Zhou H, Hu J, Chen X, Wang X-H., Yuan-Y, Tang M-H, Wen J, Wei Y-Q.Synergistic Antitumor Effects of Liposomal Honokiol Combined with Adriamycin inBreast Cancer models. Phytother Res . 2008,22: 1125-1132 . （IF=1.772 ）
· Zhang F, Tang M-H, Chen L-J*, Li R, Wang X-H, Duan J-G, Zhao X, Wei Y-Q . Simultaneous quantitation of aconitine,mesaconitine, hypaconitine, benzoylaconine, benzoylmesaconine andbenzoylhypaconine in human plasma by liquid chromatography?Ctandem mass spectrometryand pharmacokinetics evaluation of “SHEN-FU”injectable powder. J Chromatogr B. 2008,873 ，173?C179 （IF=2. 5 ）
· Jiang Q-Q, Fan L-Y, Yang G-L ，Guo W-H, Liu L, Hou W-L, Nie X-H,Chen L- J* ，Wei Y-Q* .Improved Therapeutic Effectiveness by Combining Liposomal Honokiol withCisplatin in Lung Cancer Model. BMC Cancer. 2008, 16(8):242. （IF=3.087 ）
· Hu J, Chen L- J*, Liu L, Chen X, Chen P, YangG-L , Hou W-L , Tang M-H, Zhang F, Wang X-H, Zhao X, Wei Y-Q . Honokiol, APotent A nti-angiogenesis agent, in Combination with Radiotherapy ProducesSynergistic Antitumor Efficacy. Exp Mol Med. 2 008, 31;40(6):617-28. （IF=2.376 ）
· Yuan Y, Hou W-L, Tang M-H, Wang X-H, Luo H-D,Chen L-J*, Guan H, Sutherland I-A. Separation of Flavonoids from the Leaves ofOroxylum indicum by HSCCC. Chromatographia . 2008, 68, 885?C892. （IF=1.312 ）
· Wang X-H, Chen X, Chen L-J* , Wang B-Q, PengC, He C-M, Tang M-H, Zhang F, Hu J, Li R, Zhao X, Wei Y-Q. Optimizinghigh-performance liquid chromatographymethod for quantification of glucosamine using 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate derivatization in ratplasma. Biomed Chromatogr. 2008, 22 : 1265?C1271. （IF=1.592 ）
· Chen L-J * , Zhang Q, Yang G-L, Fan L-Y, TangJ, Ian G, Ignatova S, Fisher Dk and Ian A Sutherland. Rapid Purification andScale-up of Honokioland Magnolol Using High Performance CountercurrentChromatography. J. Chromatogr A, 1142: 115?C122, 2007 ( IF=3.756 ）
· Chen L-J , Zhao X* ，Fang L-Y , Games D-E. Quantitativedetermination of isoflavones and their metabolites in human urine usingcombined liquid chromatography-mass spectrometry. J Chromatogr A. 2007, 1154:103-110. （IF=3.756 ）
· Yuan Z, Zhao X-Y, Yan F, Zhao J, Liu H-Y,Xiong S-Q, Li J, Wei Y- Q, Chen L-J* . beta-synucleln protein from Xenopuslaevis: Overexpression in Escherichia coli of the GST-Tagged protein andproduction of polyclonal antibodies. Biochemistry. 2007, 72(11),1270-1278. （IF=1.8 ）
· Zhang Q, Chen L-J* , Ye H-Y, Gao L, Hou W-H,Tang M-H, Yang G-L, Zhong Z-H, Yuan Y, Peng A-H. Isolation and purification ofginkgo flavonol glycosides from Ginkgo biloba leaves by high-speedcounter-current chromatography. J Sep Sci. 2007, 30 ( 13 ): 2153-2159 . （IF=2.746 ）
· Chen L-J , Sutherland I-A*. How to achieverapid separations in counter-current chromatography . J Chromatogr A.2006,1114:29-33 . （IF=3.756 ）
· Chen L-J* , Song H, Lan X-Q, Games D-E,Sutherland I.-A. Comparison of high speed countercurrent chromatographyinstruments for the separation of the extracts of the seeds of Oroxylumindicum, J Chromatogr A. 2005,1063, 241-245. （IF=3.756 ）
· Chen L-J* , Zhao X, Plummer S, Tang J, GamesD-E. Quantitative determination and structural characterization of isoflavonesin nutrition supplements by liquid chromatography-mass spectrometry. JChromatogr A. 2005, 1082, 60-70. （IF=3.756 ）
· Chen L-J* , Song H, Du Q-Z, Li J, Y. Ito.Analysis of flavonoids in the Extracts from the Seeds of Oroxylum IndicumIndicum Using High Speed Countercurrent Chromatography/Mass Spectrometry. J LiqChromatogr Rel Technol. 2005, 28 1549-1553. (IF=1.026)
· Chen L-J* , Song H, D.E. Games, I.A.Sutherland. HSCCC-MS Study of Flavonoids in the Extracts from the Seeds ofOroxylum indicum J. Liq Chromatogr Rel Technol - 28 ( 12-13) 2005,1993 - 2003(IF: 0.85)
· Chen L-J* , Games, D.E. and Jones, J. (2003)Isolation and identification of four flavonoid constituents from the seeds ofOroxylum indicum by high-speed countercurrent chromatography, J. Chromatogr A ,988, 95-105. （IF:3.641 ）
· Chen L-J* , D.E. Games, J Jones and HuwKidwell, Separation and Identification of flavonoids in an Extract from theSeeds of Oroxylum indicum by CCC. J. Liq Chromatogr Rel Technol . Vol 269&10, (2003) 1615-1628 (IF: 0.85)
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