标题：梁兴群
简介
梁兴群，女，美籍华人，现任同济大学特聘教授、博士生导师，同济大学基础医学院、上海市东方医院双聘教授，心律失常教育部重点实验室PI。
  
梁兴群，1995年博士毕业于北京协和医科大学并留校工作一年。自1996年起，先后在赫尔辛基大学，哈佛大学医学研究以及加州大学圣地亚哥分校做博士后，研究助理教授和研究副教授，先后从事耳听力损伤的分子机制，脑肿瘤发生的研究。2002年起，聚焦在心血管发育及功能，以及相关疾病模型的研究工作，取得了一定的学术成果，曾在Circulation, Circulation Research, Developmental cell，Developmental Biol，JCR, Nature，Nat Neurosci,及 MCB 等杂志发表高质量论文多篇。
办公室 61569560
电邮 x126liang@gmail。com (把。换成 . )
简历：
1990.09-1995.07：中国协和医科大学，博士
1995.07-1996.07：北京协和医院五官科，住院医生
1996.07-2001.05：赫尔辛基大学生物技术中心，博士后
2001.05-2002.10：哈佛医学研究所，哈佛大学，博士后
2002.10 -2004.07：加州大学圣地亚哥分校医学系，博士后
2004.07-2010.05：加州大学圣地亚哥分校医学系，研究助理教授
2010.05-2011 ：加州大学圣地亚哥分校医学系，研究副教授
2011 -至今 ：同济大学特聘教授，心律失常教育部重点实验室PI，上海市东方医院心血管内科学硕士生、博士生导师。
代表性论文：
1. Maoqing Ye , Chris Coldren, Xingqun Liang, Teresa Mattina , Elizabeth Goldmuntz D. Woodrow Benson, Dunbar Ivy, MB Perryman, Lee Ann Garrett-Sinha, Paul Grossfeld. Deletion of ETS-1, a gene in the Jacobsen syndrome critical region, causes ventricular septal defects in mice. Human Molecular Genetics. 2010 Nov 19(4):648-656.
2. Liang X, Yunfu Sun and Ju Chen. Particularly Interesting Cysteine- and Histidine-Rich Protein in Cardiac Development and Remodeling. J Investig Med. 2009 Dec 57(8):842-8.
3. Liang,X, Yunfu Sun, Maoqing Yi, Maria C. Scimia, Hongqiang Cheng, Jody Martin, Gang Wang, Ann Rearden, Chuanyue Wu, Kirk Peterson, Henry C. Powell, Sylvia M. Evans, and Ju Chen. Targeted Ablation of PINCH1 and PINCH2 From Murine Myocardium Results in Dilated Cardiomyopathy and Early Postnatal Lethality. Circulation. 2009 Aug 18;120(7):568-76.
4. Sheikh F, Raskin A, Chu PH, Lange S, Domenighetti AA, Zheng M, Liang X, Zhang T, Yajima T, Gu Y, Dalton ND, Mahata SK, Dorn GW 2nd, Heller-Brown J, Peterson KL, Omens JH, McCulloch AD, Chen J. An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice. J Clin Invest. 2008 Dec;118(12):3870-80. doi: 10.1172/JCI34472. Epub 2008 Nov 3.
5. Yunfu Sun, Iain M. Dykes, Liang X, S. Raisa Eng, Sylvia M. Evans, Eric E. Turner. A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs. Nat Neurosci. 2008 Nov;11(11):1283-93. Epub 2008 Oct 12.
6. Cai CL*, Martin JC*, Sun Y*, Cui L, Wang L, Ouyang K, Yang L, Bu L, Liang X, Zhang X, Stallcup WB, Denton CP, McCulloch A, Chen J, Evans SM. A myocardial lineage derives from Tbx18 epicardial cells. Nature. 2008 Jul 3;454(7200):104-8. Epub 2008 May 14. (*equal contribution).
7. Liang X, Sun Y, Schneider J, Ding JH, Cheng H, Ye M, Bhattacharya S, Rearden A, Evans S, Chen J. Pinch1 is required for normal development of cranial and cardiac neural crest-derived structures. Circ Res. 2007;100(4):527-535. 
8. Sun Y*, Liang X*, Najafi N, Cass M, Lin L, Cai CL, Chen J, Evans SM. Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells. Dev Biol. 2007;304(1):286-96. (*equal contribution)
9. Farah Sheikh, Yinghong Chen, Liang X, Alain Hirschy, Antine E. Stenbit, Yusu Gu, Nancy E. Dalton, Toshi Yajima, Yingchun Lu, Elaine Fusch, Kirk U. Knowlton, Kirk L. Peterson, Jean-Claude Perriard and Ju Chen. (2006). alpha-E-Catenin Inactivation Disrupts the Cardiomyocyte Adherens Junction Resulting in Cardiomyopathy and Susceptibility to Wall Rupture. Circulation. 114(10): 1046-55.
10. Liang X, Zhou Q, Li X, Sun Y, Lu M, Ross J. Jr, and Chen J (2005). PINCH1 Plays an Essential Role in Early Murine Embryonic Development but Is Dispensable in Ventricular Cardiomyocytes. Mol. Cell. Biol. 25:3056-3062.
11. Liang X, Hava Avraham, Shuxian Jiang, Tae-Aug Kim, and Shalom Avraham (2004). Genetic alterations of NRP/B gene associated with human brain tumors. 23:5890-5900.
12. Chen-Leng Cai, Liang X, Yunqing Shi, Po-Hsien Chu, Samuel L. Pfaff, Ju Chen, and Sylvia Evans (2003). Isl1 Identifies a Cardiac Progenitor Population that Proliferates Prior to Differentiation and Contributes a Majority of Cells to the Heart. Dev Cell. 5:877-89.
13. Ylikoski J, Liang X, Virkkala J, Pirvola U (2002). Blockade of c-Jun N-terminal kinase pathway attenuates gentamicin-induced cochlear and vestibular hair cell death. Hear Res.166 (1-2):33-43.
14. Jukka Ylikoski, Liang X, Jussi Virkkala and Ulla Pirvola (2002). Blockade of c-Jun N-terminal kinase pathway attenuates gentamicin-induced cochlear and vestibular hair cell death. Hear Res. 163(1-2):71-81.
15. Aarnisalo AA, Pirvola U, Liang X, Miller J, Ylikoski J. (2000). Apoptosis in auditory brainstem neurons after a severe noise trauma of the organ of corti: intracochlear GDNF treatment reduces the number of apoptotic cells. ORL J Otorhinolaryngol. 62:330-4.
16. Pirvola U, Spencer-Dene B, Liang X, Kettunen P, Thesleff I, Fritzsch B, Dickson C, Ylikoski J (2000). FGF/FGFR-2 (IIIb) signaling is essential for inner ear morphogenesis. J Neurosci. 20:6125-34.
17. Pirvola U, Liang X, Virkkala J, Saarma M, Murakata C, Camoratto AM, Walton KM, Ylikoski J. (2000). Rescue of hearing, auditory hair cells, and neurons by CEP-1347/KT7515, an inhibitor of c-Jun N-terminal kinase activation. J Neurosci. 20:43-50.
18. Liang X, Pirvola U, Saarma M, Ylikoski J.(1999). Neurotrophic factors in the auditory periphery. Ann N Y Acad Sci. 884:292-304.
19. Liang X, Dao-Feng Ni, Zheng-Zhong Wang (1999). Suppressing effect of substance P receptor antagonist on sound evoked potentials the guinea pig cochlea. Chinese Medical J. 112:129-131.
20. Ylikoski J, Pirvola U, Virkkala J, Suvanto P, Liang X, Magal E, Altschuler R, Miller JM, Saarma M. (1998). Guinea pig auditory neurons are protected by glial cell line-derived growth factor from degeneration after noise trauma. Hear. Res. 124:17-26.
21. Liang X, Dao-Feng Ni, Zheng-Zhong Wang (1998). Changes in the expression of Substance P in auditory nuclei of rats deafened by kanamycin. Chinese J. of Otorhinolaryngology;33:24-26。
22. Pirvola U, Hallbook F, Liang X, Virkkala J, Saarma M, Ylikoski J. (1997). The Neurotrophic System in the Developing, Adult, and Regenerating Avian Cochlea. J. Neurobiolog. 7:1019-1033.
23. Liang X, Ni Diaofeng (1995). The Rapid Development of Animal Models of Various Deaf Degrees. J. Auditory and Speech Disorder. 20-4.
24. Ni D, Song M, Liang X (1995). An experimental study of middle ear implantable hearing device. Chinese Medical J.; 75:360-2.
25. Dao-Feng Ni, Feng-Lan Song, Liang X, Zheng-Zhong Wang (1995). The middle ear implant in the guinea pig. Chinese J. Clinical 8:201-4. 
26. Liang X, Dao-Feng Ni, Zheng-Zhong Wang (1994). Functional reorganization of the central auditory nuclei after hearing losses. J.Auditory and Speech Disorder. 2:153-5.
专著章节：
1. Yunfu Sun, Liang X, and Sylvia Evans. (2007). Islet1 Progenitors in Developing and Postnatal Heart Cardiovascular Development. Advance in Developmental Biology. 2008 (18): 154-65.
2. Shalom Avraham, Hava Avraham, Shuxian Jiang, Xia Bu, Liang X, Seyha Seng and Tae-Aug Kim (2002). The superfamily of proteins containing Kelch and/or BTB domains: From cytoskeleton dynamics to transcriptional regulation. Recent Res. Devel. Bio. Chem. (Review, book). 1:231-254. 
会议摘要：
1.Xing-Qun Liang Ulla Pirvola, Jukka Ylikoski. Organ culture of the rat cochlea as an in vitro model to study the mechanisms of ototoxicity and hair cell protection. ARO 1999, abstract # 56.
2. Ulla Pirvola, Xing-Qun Liang, Nina Trokovic, Ylikoski, Juha Partanen. FGFR signaling is required for the formation of the auditory sensory epithelium. ARO 2001, abstract # 266.
3. Xing-Qun Liang Ulla Pirvola, Jukka Ylikoski. Role of stress-activated protein kinases in cochlear hair cell death induced by ototoxic drugs. ARO 2001, abstract #545
4. Jukka Ylikoski, Xing-Qun Liang Ulla Pirvola c- Jun phosphorylation by c-jun N-terminal kinase (JNK) mediates cochlear hair cell death induced by noise and neomycin, but not by cisplatin. ARO 2001, abstract
成员和获奖
1）. 1993年中国医学科学院优秀博士生 
2）. 国际耳鼻喉协会成员。1998 - 2001
3）. 2009加州大学圣迭戈分校杰出心血管研究舒尔曼奖
研究方向
1. PINCHs在胚胎发育，心血管发育，心肌功能和 心肌再生中的作用及分子机制。 
2. 整合素连接激酶在神经嵴特异性及流出道的发育形成中的作用和分子机制。
3. Islet1在心脏的形成中的作用
4. Nebulette在心脏Z线的组装和在心肌动作稳定性中的作用。 
5. 在Tbx18在脊椎的发展和在感觉神经通路的形成中的作用。
课题与项目
1.国家自然科学基金面上项目
2.上海市科委创新项目 
3.同济大学基础研究预研类项
4.同济大学985计划项目
5.上海市浦江人才计划
6.国家973计划
7.同济大学附属东方医院特聘教授启动经费
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