标题：胡凯锋
个人简介
胡凯锋，男，1974年02生， 研究员，中国科学院昆明植物研究所 博士生导师  
教育背景
1995年　北京医科大学(现北京大学医学部), 学士
1998年　中国科学院上海药物研究所，　硕士
1998.9 -2000.10 美国马里兰大学药学院，　 博士生
2004　 瑞士联邦高等理工学院 (ETH)，　博士
2005 - 2008　美国国立卫生研究院（NIH, NIDDK） 博士后
2009 - 2012　美国威斯康星大学(NMRFAM)　助理科学家
2012 - 至今　中国科学院昆明植物研究所 研究员、博士生导师
2012.2 　入选“青年千人计划”
研究领域
核磁共振技术，结构生物学，代谢组学。
1. 基于核磁共振技术的结构生物学：与重大疾病相关或者与重要生命过程相关的蛋白质的空间三维结构；
基于结构生物学的药物发现；研究靶标蛋白质分子与化学小分子之间的相互作用以及小分子药物对生物大分子功能的调节作用；
2. 基于结合核磁共振技术和液质联用技术的代谢组学：发现与重大疾病相关的生物分子标识物；
3. 中药多组分成分分析，结合核磁共振技术和液质联用技术，建立基于中药有效生物活性成分的中药质量评价体系
4. 核磁共振技术新方法开发与应用
代表论著：
1. Kaifeng Hu, Alexander Eletsky and Konstantin Pervushin*, Backbone resonance assignment in large protonated proteins using a combination of new 3D TROSY-HN(CA)HA, 4D TROSY-HACANH and C detected HACACO experiments. (2003) J. Biomol NMR, 26 (1), 66-77.
2. Kaifeng Hu*, Beat V&ouml;geli and Konstantin Pervushin*, Side-chain H and C resonance assignment in protonated / partially deuterated proteins using an improved 3D 13C-detected HCC-TOCSY. (2005) Journal of Magnetic Resonance, 174 (2), 200-208.
3. Kaifeng Hu&para;, Beat V&ouml;geli&para; and G. Marius Clore*, Interference between transverse cross-correlated relaxation and longitudinal relaxation affects apparent J-coupling and transverse cross-correlated relaxation. (2006) Chem. Phys. Letter, 423, 123-125
4. Kaifeng Hu*, VeniaminGalius, and Konstantin Pervushin*,Structural plasticity of peptidyl-prolylisomerasesFkpA is a key to its chaperone function as revealed by solution NMR. (2006) Biochemistry,45(39), 11983-11991
5. Kaifeng Hu&para;, Beat V&ouml;geli&para; and G. Marius Clore*,13C-detected HN(CA)C and HMCMC experiments using a single methyl-reprotonated sample for unambiguous methyl resonance assignment. (2006) J. Biomol NMR, 36(4), 259-66.
6. Maria U. Johansson*, Simon Alioth, Kaifeng Hu, RetoWalser, Ralf Koebnik and Konstantin Pervushin*, A minimal transmembraneβ-barrel platform protein studied by NMR. (2007) Biochemistry, 46(5), 1128-1140.
7. Kaifeng Hu, Beat V&ouml;geli and G. Marius Clore*, Spin state selective 13C-detected HNCO with TROSY optimization in all dimensions and double echo-antiecho sensitivity enhancement in both indirect dimensions. (2007) J. Am. Chem. Soc., 129(17), 5484-91.
8. Jun Hu&para;, Kaifeng Hu&para;, David C. Williams Jr., Michal Komlosh, MengliCai and G. Marius Clore*, Solution NMR structures of productive and non-productive complexes between the A and B domains of the cytoplasmic subunit of the mannose transporter of the Escherichia coli phosphotransferase system, (2008) J. Biol. Chem. 283, 11024-11037.
9. Kaifeng Hu, MichaeleenDoucleff and G. Marius Clore*, Using multiple quantum coherence to increase the 15N resolution in a three-dimensional TROSY HNCO experiment for accurate PRE and RDC measurements, (2009) Journal of Magnetic Resonance, 200 (2), 173-177.
10. Zheng Zhou, HanqiaoFeng, Bing-Rui Zhou, Rodolfo Ghirlando, Kaifeng Hu, Adam Zwolak, Lisa M. Jenkins, Hua Xiao, NicoTjandra, Carl Wu, &YawenBai*, Structural basis for recognition of centromere specific histone H3 variant by nonhistone Scm3, (2011) Nature, 472(7342), 234-7.
11. Kaifeng Hu, William M. Westler, and John L. Markley*, Simultaneous quantification and identification of individual chemicals in metabolite mixtures by two-dimensional extrapolated time-zero 1H-13C HSQC (HSQC0), (2011) J. Am. Chem. Soc., 133(6), 1662-5.
12. Kaifeng Hu, William M. Westler and John L. Markley*,Two-dimensional concurrent HMQC-COSY as an approach for small molecule chemical shift assignment and compound identification, (2011) J. Bio. NMR. 49(3-4), 291-6.
13. Roger A. Chylla*, Kaifeng Hu, James J. Ellinger, and John L. Markley, Deconvolution of Two-Dimensional NMR by Fast Maximum Likelihood Reconstruction (FMLR): Application to Quantitative Metabolomics, (2011) Analytical Chemistry. 83(12), 4871-80.
14. Kaifeng Hu, Thomas P. Wyche, Tim S. Bugni and John L. Markley*, Selective Quantification by 2D HSQC0 Spectroscopy of Thiocoraline in an Extract from a Sponge-DerivedVerrucosisporasp., (2011) Journal of Natural Products, 74(10), 2295-8.
15. Kaifeng Hu*, James J. Ellinger, Roger A. Chylla and John L. Markley, Measurement of Absolute Concentrations of Individual Compounds in Metabolite Mixtures by Gradient-Selective Time-Zero 1H-13C HSQC (gsHSQC0) with Two Concentration References and Fast Maximum Likelihood Reconstruction Analysis, (2011) Analytical Chemistry, 83(24), 9352-60.
16. Williard J. Werner, Kylie D. Allen, Kaifeng Hu, Gregory L. Helms, Brian S. Chen, and Susan C Wang*, In vitro Phosphinate Methylation by PhpK from KitasatosporaPhosalacinea, (2011) Biochemistry,50(42), 8986-8.