标题：杨茂君
简介
杨茂君，男，博士，清华大学生命科学院教授、博导。  [1]
个人简历
1995-1999年就读于吉林大学生物系获学士学位；
1999-2003年于中国协和医科大学生物化学与分子生物学系攻读博士学位；
2004-2008年于美国西南医学研究中心药理系从事博士后研究；
2008年受聘于清华大学生命科学学院担任教授、博导;[1]
研究方向

细胞有丝分裂检查点相关蛋白质的结构与功能研究 
癌症发生相关蛋白质的结构与特异性抑制剂的筛选与设计
[1]
论文
Feng Y, Gao J, Yang M#. When MAGE meets RING: insights into biological functions of MAGE proteins. Protein&Cell. 2011,2(1), 7-12 (#corresponding)Doyle. J*, Gao J*, Wang JW*, Yang M#, and Potts.R.P#.MAGE-RING protein complexes form a novel family of E3 ubiquitin Ligases. Mol Cell. 2010 Sep 24 (#corresponding)Kang J, Yang M*, Li B, Qi W, Zhang C, Shokat KM, Tomchick DR, Machius M, Yu H.Structure and substrate recruitment of the human spindle checkpoint kinase Bub1.Mol Cell. 2008 Nov 7;32(3):394-405.PMID: 18995837(The single asterisk indicates equal contributions.)Yang M, Li B, Liu C,Tomchick DR, Machius M, Rizo J, Yu H, Luo X. Structure of the symmetric Mad2 dimer supports a two-state model for Mad2 regulation in the spindle checkpoint. PLoS Biol. 2008 Mar 4;6(3):e50; PMID: 18318601Yang M, Li B, Tomchick DR, Machius M, Rizo J, Yu H, Luo X. Blockage of Mad2 activation by p31comet through structural mimicry. Cell. 2007 Nov 16;131(4):744-55;PMID: 18022368Yang M, Szewczuk LM, Culhane JC, Jalili P, Ball HL, Machius M, Cole PA, Yu H. Structural basis for inhibition of the LSD1 histone demethylase by the antidepressant trans-2-Phenylcyclopropylamine. Biochemistry. 2007 Jun 15; PMID: 17569509Yang M*, Culhane JC*, Szewczuk LM*, Gocke CB, Brautigam CA, Tomchick DR, Machius M, Cole PA, Yu H. Structural basis of histone demethylation by LSD1 revealed by suicide inactivation. Nat Struct Mol Biol. 2007 May 27. PMID: 17529991(The single asterisk indicates equal contributions.)Yang M, Gocke CB, Luo X, Borek D, Tomchick DR, Machius M, Otwinowski Z, Yu H.. Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase. Mol Cell. 2006 Aug 4;23(3):377-87. PMID: 16885027Yang M, Xu G, Li S, Sun L, Shi N, Zeng W, Pang H, Zhang W, Rao Z. Crystallization and preliminary crystallographic analysis of the extracellular fragment of FcalphaRI/CD89. Acta Crystallogr D Biol Crystallogr. 2003 Dec;59(Pt 12):2251-3.PMID: 14646085Yang H*, Yang M*, Ding Y*, Liu Y, Lou Z, Zhou Z, Sun L, Mo L, Ye S, Pang H, Gao GF, Anand K, Bartlam M, Hilgenfeld R, Rao Z. The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13190-5. PMID: 14585926. (The single asterisk indicates equal contributions.)Yang M, Li S, Liang G, Sun L, Zhang X, Liu N, Pang H, Miao S, Wang L, Rao Z. Crystallization and preliminary crystallographic analysis of RSB-66, a novel round spermatid-specific protein. Acta Crystallogr D Biol Crystallogr. 2003 Oct;59(Pt 10):1853-5. PMID: 14501136Ding Y*, Xu G*, Yang M*, Yao M, Gao GF, Wang L, Zhang W, Rao Z. Crystal structure of the ectodomain of human FcalphaRI. J Biol Chem. 2003 Jul 25;278(30):27966-70.PMID: 12783876. (The single asterisk indicates equal contributions.)Yang M, Zhou W, Zhang X, Hu W, Gao F, Pang H, Miao S, Wang L, Rao Z. Crystallization and preliminary crystallographic analysis of extracellular fragment X3 of YWK-II/APPH: a human sperm membrane protein related to the Alzheimer betaA4-amyloid precursor protein. Acta Crystallogr D Biol Crystallogr. 2003 Mar;59(Pt 3):506-8.PMID: 12595709Yang M, Liu B, Zhang X, Zhou W, Gao F, Pang H, Miao S, Wang L, Rao Z. Crystallization and preliminary crystallographic analysis of a partial extracellular fragment of a sperm membrane protein YWK-II/APPH related to the Alzheimer betaA4-amyloid precursor protein Acta Crystallogr D Biol Crystallogr. 2003 Jan;59(Pt 1):146-9. PMID: 12499552[1]