标题：田志刚
个人履历
原山东省医学科学院基础医学研究所所长、山东肿瘤生物治疗研究中心主任、山东省肿瘤免疫与基因工程重点实验室主任。2001年作为中国科学院"百人计划"引进人才进入中国科技大学生命科学学院，博士，博士生导师，教授，中国科技大学免疫学研究所所长，现任中国科技大学生命学院院长，兼美国国立卫生研究院癌症研究所研究员和日本金泽大学国立癌症研究所教授。国家自然科学基金生命科学部专家评审组专家，国家名词（免疫学）评审委员会专家，中国免疫学会常务理事，中国抗癌协会理事，中国医药生物技术协会理事。
1993年开始五次赴美国国立卫生研究院癌症研究所进行合作研究，专门从事肿瘤免疫与抗癌基因工程药物的研究与开发，在美研究期间的三项产品申报FDA并获批进入临床试验。1996年成为国家"百千万人才工程"一、二层次专家，2001年获国际抗癌联盟研究项目奖。1990年以来，共主持40余项国家、省、部级等科研项目。现承担国家杰出青年基金项目、国家自然科学基金重点项目、国家973项目、国家863项目、中科院知识创新工程项目、安徽省十五重大医药专项项目。
成就及荣誉
先后获省部级科技进步二等奖3项、三等奖8项。近年来共发表论文250余篇，英文刊物发表论文23篇，17篇收入SCI。在国内最先（1989年）综合系统地引入肿瘤生物治疗学。1989年创建国内第一家肿瘤生物治疗研究机构（山东肿瘤生物治疗中心）并发起创建"中国免疫学会肿瘤生物治疗分会"并任副主任委员。建成国家卫生部批准的首批"细胞治疗实验室"，探索出三套肿瘤生物治疗方案并应用于临床。先后研制四类10余种单抗和PCR试剂盒。自1990年起开展基因工程药物研究，先后研制了IL-2、IL-6、IL-10、IL-12、IL-15、IL-18、SCF、leptin等重组产品，部分转让中试工艺。被称为“中国免疫第一人”。
研究兴趣
主要研究天然杀伤（NK）细胞的基础生物学特性、相关生物治疗技术与重组产品及其用于治疗重大疾病（癌症、传染病、自身免疫病、器官与骨髓移植）的应用基础研究。
近五年代表性研究论文
Zhigang Tian,Dan L. Longo,Satoshi Funakoshi,Osamu Asai,Douglas K.Ferris,Michael Widmer,and William J. Murphy（1995）. In vivo antitumor effects of unconjugated CD30 monoclonalantibodies on human anaplastic large-cell lymphoma xenograft. Cancer Res.,55,5335.　William J. Murphy,Zhigang Tian,Osamu Asai,Satoshi Funakoshi,Poppy Rotter,Michelle Henry,Robert M. Strieter,Steven L. Kunkel,Dan L. Longo,and Dennis D. Taub. Chemokines and T lymphocyte activation （1996）. Ⅱ. Facilitation of human T cell trafficking in severe combined immunodeficiency Mice. J Immunol,156,2104.　William J. Murphy,Osamu Asai,Zhigang Tian,Dan L. Longo （1996）. Activated natural killer (NK) cells mediate GVT effect but inhibite GVHD after allogeneic bone marrow transplantation. FASEB J. 10⑹，2509.　Satoshi Funakoshi,Akio Hirano,Margarret Beckwith,Osamu Asai,Gitte Jorgensen,Zhigang Tian,Jason L.Hornick,Peisheng Hu,Leslie A.Khawli,Alan L.Epstein,Dan L. Longo,and William J. Murphy （1997）. Antitumor Effect of Nonconjugated Murine Lym-2 and Human-Mouse Chimeric CLL-1 Monoclonal Antibodies Against Various Human Lymphoma Cell Lines In Vitro and In Vivo. Blood,90⑻，3160.　Zhigang Tian,Mary Alice Woody,Rui Sun,Lisbeth A.Welniak,Arati Razilddin,Satoshi Funakoshi,Galla Tsarfaty,Dan L.Longo,William J. Murphy （1998）. Recombinant Human Growth Hormone Promotes Hematopoietic Reconstitution after Syngeneic Bone Marrow Transplantation in Mice. Stem Cells,16,193.　Osamu Asai,Dan L. Longo,Zhigang Tian,Ronald L.Hornung,Dennis D. Taub,Francis W.Ruscetti,and William J. Murphy （1998）. Suppression of Graft- Versus-Host Disease and Amplication of Graft-Versus-Tumor Effects by Activated Natural Killer Cells after Allogeneic Bone Marrow Transplantation. J. Clin. Invest.,101,1835.　Mary Alice Woody,Lisbeth A.Welniak,Rui Sun,Zhigang Tian,Michelle Henry,Susan Richards,Arati Raziuddin,Dan L. Longo,and William J.Murphy （1999）. Prolactin Exerts Hematopoietic Growth-Promoting Effects in Vivo and Partially Counteracts the Myelosuppressive Effects of Azidothymidine. Exp Hematol,27⑸，811.　Mary A. Woody,Lisbeth A.Welniak,Dennis D. Taub,Zhigang Tian,Rui Sun,Dan L. Longo,and William J. Murphy （1999）. Use of Neuroendocrine Hormones to promote reconstitution after bone marrow transplantation. Neuroimmunomodulation,6,69-80.　Lisbeth A.Welniak,Zhigang Tian,Rui Sun,Jonathan R. Keller,Susan Richards,Francis W. Ruscetti and William J. Murphy （2000). Effects of Growth Hormone and Prolactin on Hematopoiesis. Leukemia and Lymphoma,38,435-45.　Xuening Shen,Zhigang Tian,Michael J.Holtzman,Bin Gao （2000). Cross-talk Between Interleukin1b (IL-1b) and IL-6 Signaling Pathways,IL-1b Selectively Inhibit IL- 6- induced STAT1 Activation by a Proteasome-dependent Mechanism. Biochem J. 352 Pt 3,913-9.　Zhigang Tian,Xuening Shen,Feng Hong,George Kunos,Bin Gao （2000). IL-1b inhibits IFNb-induced STAT1 activation through NF-kB pathway in rat hepatocytes and human HepG2 cells. J. Immunol,165⑺，3959-65.　Yao Chengfan,Cai Shengye,Wei Haiming,Wang Li,Sun Rui and Zhigang Tian （2000). Chinese traditional herb reverses the Th1/Th2 umbanlance in Yang-deficient mice. Biotherapy,14⑾，1121-27.　Hong Feng,Won-Ho Kim,Zhigang Tian,Barbara Jaruga,Edward Ishac,Xuening Shen and Bin Gao （2002）. Elevated interleukine-6 during ethanol consuption acts as a potential endogenous protective cytokine against ethanol-induced apoptosis in the liver,involvement to induction of Bcl-2 and Bcl-XL protein. Oncogen,21,32-43.　Sun R,Wei H,Zhang J,Li A,Zhang W,Tian Z （2002）. Recombinant Human Prolactin Improves Antitumor Effects of Murine Natural Killer Cells in vitro and in vivo. Neuroimmunomodulation. 10,169-176.　Tian Z,Sun R,Wei H,Gao B （2002）. Impaired natural killer (NK) cell activity in leptin receptor deficient mice,leptin as a critical regulator in NK cell development and activation. Biochem Biophys Res Commun. 298,297-302.　Liu J,Tian Z,Gao B,Kunos G （2002）. Dose-dependent activation of antiapoptotic and proapoptotic pathways by ethanol treatment in human vascular endothelial cells,differential involvement of adenosine. J Biol Chem. 277,20927-33.　Hong F,Jaruga B,Kim WH,Radaeva S,El-Assal ON,Tian Z,Nguyen VA,Gao B （2002）. Opposing roles of STAT1 and STAT3 in T cell-mediated hepatitis,regulation by SOCS. J Clin Invest. 110,1503-13.　Zhao Y,Sun R,You L,Gao C,Tian Z （2003）. Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines. Biochem Biophys Res. Commun. 300,247-52.