标题：氟乙酸甲酯
基本信息
中文名称：氟乙酸甲酯
中文别名：甲基氟乙酸酯
英文名称：Methyl fluoroacetate 
英文别名：FLUOROACETIC ACID METHYL ESTER; Acetic acid, fluoro-, methyl ester; Aceticacid,fluoro-,methylester; Fluoracetic acid methyl ester; fluoro-aceticacimethylester; Methylester kyseliny fluoroctove; methylesterkyselinyfluoroctove; TL 551; tl551; Methyl fluoroacetate 99%; Methylfluoroacetate99%; ethanoic acid,fluoro-,methyl ester; METHYLESTEROFETODOLAC; CHEM-2063
分子式(Formula)： C3H5FO2 
分子量(Molecular Weight)： 92.07 
CAS No.： 453-18-9 
EINECS号：207-218-7[1]
质量指标(Specification)
外观（Appearance）： 无色透明液体 
含量（Purity）： 工业级≥99% 
包装（Package）： 100公斤/桶 
物化性质(Physical Properties)
外观性状 无色透明液体
沸点 104.5℃
相对密度 1.1744
闪点 -32℃
蒸气压（20℃）为80Pa
折射率 1.3679。
储运(Storeage)
桶阴凉处密封保存。 
用途(Useage)
【用途一】用作医药、农药、染料中间体
【用途二】氟乙酸甲酯为生产氟啶酸、环丙氟啶酸、5-氟尿嘧啶、氟苷、喃氟啶、双呋啶5-氟-4-羟基嘧啶等药物的基本原料，也是农药、香料中间体。
【用途三】氟乙酸甲酯为生产氟啶酸、环丙氟啶酸、5-氟尿嘧啶、氟苷、喃氟啶、双呋啶、5-氟-4-羟基嘧啶等药物的基本原料。
安全术语
S16 Keep away from sources of ignition.
远离火源。
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。
S36 Wear suitable protective clothing.
穿戴适当的防护服。
风险术语
R10 Flammable. 
易燃。
R36/37/38 Irritating to eyes, respiratory system and skin. 
刺激眼睛、呼吸系统和皮肤。
物质毒性
编号毒性类型测试方法测试对象使用剂量毒性作用1acute Oral Human - man 650 ug/kg 1.胃肠道毒性Gastrointestinal - nausea or vomiting 2acute Oral Rodent - rat 3500 ug/kg 1.行为毒性Behavioral - convulsions or effect on seizure threshold2.心脏毒性Cardiac - arrhythmias (including changes in conduction)3.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - dyspnea 3acute Inhalation Rodent - rat 300 mg/m3/10M 1.Details of toxic effects not reported other than lethal dose value 4acute Subcutaneous Rodent - rat 5 mg/kg 1.行为毒性Behavioral - tremor2.行为毒性Behavioral - convulsions or effect on seizure threshold3.行为毒性Behavioral - excitement 5acute Intramuscular Rodent - rat 2500 ug/kg 1.Details of toxic effects not reported other than lethal dose value 6acute Oral Rodent - mouse 5 mg/kg 1.行为毒性Behavioral - convulsions or effect on seizure threshold2.心脏毒性Cardiac - arrhythmias (including changes in conduction)3.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - dyspnea 7acute Inhalation Rodent - mouse 3200 mg/m3/10M 1.Details of toxic effects not reported other than lethal dose value 8acute Intraperitoneal Rodent - mouse 7500 ug/kg 1.Details of toxic effects not reported other than lethal dose value 9acute Subcutaneous Rodent - mouse 5 mg/kg 1.行为毒性Behavioral - convulsions or effect on seizure threshold2.心脏毒性Cardiac - arrhythmias (including changes in conduction)3.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - dyspnea 10acute Intravenous Rodent - mouse 17 mg/kg 1.行为毒性Behavioral - coma2.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - respiratory stimulation3.胃肠道毒性Gastrointestinal - changes in structure or function of salivary glands 11acute Parenteral Rodent - mouse 6 mg/kg 1.行为毒性Behavioral - convulsions or effect on seizure threshold 12acute Oral Mammal - dog 100 ug/kg 1.行为毒性Behavioral - convulsions or effect on seizure threshold2.心脏毒性Cardiac - arrhythmias (including changes in conduction)3.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - dyspnea 13acute Inhalation Mammal - dog 25 mg/m3/10M 1.行为毒性Behavioral - coma2.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - respiratory stimulation3.胃肠道毒性Gastrointestinal - changes in structure or function of salivary glands 14acute Subcutaneous Mammal - dog 100 ug/kg 1.行为毒性Behavioral - convulsions or effect on seizure threshold2.心脏毒性Cardiac - arrhythmias (including changes in conduction)3.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - dyspnea 15acute Intravenous Mammal - dog 60 ug/kg 1.大脑毒性Brain and Coverings - recordings from specific areas of CNS2.行为毒性Behavioral - convulsions or effect on seizure threshold3.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - respiratory depression 16acute Oral Primate - monkey 10 mg/kg 1.行为毒性Behavioral - convulsions or effect on seizure threshold2.心脏毒性Cardiac - arrhythmias (including changes in conduction)3.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - dyspnea 17acute Inhalation Primate - monkey 800 mg/m3/10M 1.行为毒性Behavioral - convulsions or effect on seizure threshold2.心脏毒性Cardiac - arrhythmias (including changes in conduction)3.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - dyspnea 18acute Subcutaneous Primate - monkey 10 mg/kg 1.行为毒性Behavioral - convulsions or effect on seizure threshold2.心脏毒性Cardiac - arrhythmias (including changes in conduction)3.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - dyspnea 19acute Intravenous Primate - monkey 4 mg/kg 1.行为毒性Behavioral - convulsions or effect on seizure threshold2.行为毒性Behavioral - muscle contraction or spasticity3.胃肠道毒性Gastrointestinal - changes in structure or function of salivary glands 20acute Unreported Primate - monkey >50 mg/kg 1.Details of toxic effects not reported other than lethal dose value 21acute Oral Mammal - cat 300 ug/kg 1.行为毒性Behavioral - coma2.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - respiratory stimulation3.胃肠道毒性Gastrointestinal - changes in structure or function of salivary glands 22acute Inhalation Mammal - cat 25 mg/m3/10M 1.行为毒性Behavioral - convulsions or effect on seizure threshold2.心脏毒性Cardiac - arrhythmias (including changes in conduction)3.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - dyspnea 23acute Subcutaneous Mammal - cat 300 ug/kg 1.行为毒性Behavioral - coma2.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - respiratory stimulation3.胃肠道毒性Gastrointestinal - changes in structure or function of salivary glands 24acute Intravenous Mammal - cat 200 ug/kg 1.行为毒性Behavioral - convulsions or effect on seizure threshold2.心脏毒性Cardiac - arrhythmias (including changes in conduction)3.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - dyspnea 25acute Oral Rodent - rabbit 500 ug/kg 1.行为毒性Behavioral - coma2.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - respiratory stimulation3.胃肠道毒性Gastrointestinal - changes in structure or function of salivary glands 26acute Inhalation Rodent - rabbit 25 mg/m3/10M 1.Details of toxic effects not reported other than lethal dose value 27acute Administration onto the skin Rodent - rabbit 20 mg/kg 1.行为毒性Behavioral - convulsions or effect on seizure threshold 28acute Subcutaneous Rodent - rabbit 300 ug/kg 1.行为毒性Behavioral - convulsions or effect on seizure threshold2.心脏毒性Cardiac - arrhythmias (including changes in conduction)3.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - dyspnea 29acute Intravenous Rodent - rabbit 200 ug/kg 1.行为毒性Behavioral - convulsions or effect on seizure threshold2.心脏毒性Cardiac - arrhythmias (including changes in conduction) 30acute Intraperitoneal Mammal - pig 400 ug/kg 1.行为毒性Behavioral - convulsions or effect on seizure threshold2.心脏毒性Cardiac - arrhythmias (including changes in conduction)3.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - other changes 31acute Oral Rodent - guinea pig 500 ug/kg 1.行为毒性Behavioral - coma2.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - respiratory stimulation3.胃肠道毒性Gastrointestinal - changes in structure or function of salivary glands 32acute Inhalation Rodent - guinea pig 100 mg/m3/10M 1.行为毒性Behavioral - convulsions or effect on seizure threshold 33acute Intraperitoneal Rodent - guinea pig 350 ug/kg 1.行为毒性Behavioral - tremor2.行为毒性Behavioral - convulsions or effect on seizure threshold3.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - respiratory depression 34acute Subcutaneous Rodent - guinea pig 200 ug/kg 1.行为毒性Behavioral - coma2.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - respiratory stimulation3.胃肠道毒性Gastrointestinal - changes in structure or function of salivary glands 35acute Intraperitoneal Rodent - hamster 2500 ug/kg 1.行为毒性Behavioral - convulsions or effect on seizure threshold2.行为毒性Behavioral - excitement3.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - dyspnea 36acute Intravenous Bird - chicken 15 mg/kg 1.Details of toxic effects not reported other than lethal dose value 37acute Subcutaneous Amphibian - frog 100 ug/kg 1.行为毒性Behavioral - convulsions or effect on seizure threshold2.心脏毒性Cardiac - arrhythmias (including changes in conduction)3.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - dyspnea 38acute Unreported Amphibian - frog 300 mg/kg 1.周围神经毒性Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage)2.行为毒性Behavioral - convulsions or effect on seizure threshold 39acute Oral Mammal - domestic 1 mg/kg 1.行为毒性Behavioral - coma2.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - respiratory stimulation3.胃肠道毒性Gastrointestinal - changes in structure or function of salivary glands 40acute Inhalation Mammal - domestic 200 mg/m3/10M 1.行为毒性Behavioral - coma2.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - respiratory stimulation3.胃肠道毒性Gastrointestinal - changes in structure or function of salivary glands 41acute Subcutaneous Mammal - domestic 1 mg/kg 1.行为毒性Behavioral - coma2.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - respiratory stimulation3.胃肠道毒性Gastrointestinal - changes in structure or function of salivary glands 42acute Intravenous Mammal - domestic 600 ug/kg 1.心脏毒性Cardiac - arrhythmias (including changes in conduction) 43acute Intramuscular Mammal - domestic 600 ug/kg 1.心脏毒性Cardiac - arrhythmias (including changes in conduction) 44acute Intramuscular Mammal - horse, donkey 500 ug/kg 1.大脑毒性Brain and Coverings - recordings from specific areas of CNS2.行为毒性Behavioral - excitement3.心脏毒性Cardiac - arrhythmias (including changes in conduction) 45MutipleDose Oral Mammal - dog 125 ug/kg/5D-I 1.行为毒性Behavioral - convulsions or effect on seizure threshold2.慢性病相关毒性Related to Chronic Data - death [2-11]