标题：林英武
基本情况
林英武，男，1976年6月生，安徽安庆人，博士，南华大学副教授，硕士生导师，湖南省青年骨干教师，南华大学化学化工学院副院长，南华大学生命科学中心副主任，南华大学侨联副主席，无机与分析化学研究所所长。2005年12月博士毕业于复旦大学化学系，导师黄仲贤教授。2008年7月-2010年6月在美国伊利诺伊大学香槟分校（University of Illinois at Urbana-Champaign, UIUC）化学系从事博士后研究（导师：Prof. Yi Lu）。研究领域涉  及金属蛋白的分子设计与分子模拟，以及金属蛋白结构-性质-反应-功能（Structure-Property-Reaction-Function, SPRF）关系研究。目前，相关科研成果发表于Nature、PNAS、JACS、Chem Commun、Proteins、ChemBioChem、Chem Lett、J Mol Model、化学进展等国内外期刊累计70余篇。
主持基金项目
1.国家自然科学基金青年基金项目
2.南京大学配位化学国家重点实验室开放基金项目
3.湖南省自然科学青年基金项目
4.湖南省教育厅青年基金项目
5.教育部留学回国人员启动基金
6.南华大学留学回国人员启动基金
代表性SCI论文
201339.Ying-Wu Lin,Elizabeth B.Sawyer*,Jiangyun Wang*. Rational Heme Protein Design: All Roads Lead to Rome. Chem Asian J,2013,DOI:10.1002/asia.201300291(Invited review).
38.Lin Ying-Wu*, Dong Shan-Shan, Liu Jiang-Hua, Nie Chang-Ming, Wen Ge-Bo. Peroxidase activity of a myoglobin with three distal histidines forming a metal-binding site: Implications for the cross-reactivity of cytochromecoxidase.J Mol Catal B: Enzym, 2013, 91: 25-31.
37. Liu Yi, Wang Qingli, Wei Yaozhu,Lin Ying-Wu, Li Wei, Su Ji-Hu, Wang Zhen, Tian Yang, Zhong- Xian Huang and Xiangshi Tan*. Functional conversion of nickel-containing metalloproteins via molecular design: from a truncated acetyl-coenzyme A synthase to a nickel superoxide dismutase.Chem Commun,2013, 49, 1452-1454.201236.Lin Ying-Wu*,You Xiao-Xing, Chen Lie-Song, Wu Yi-Mou. Peroxidase-like enzymes designed from cytochromeb5 exhibit enhanced hydrolysis activity.Chem Lett,2012, 41(12):1574-1575.
35.Lin Ying-Wu*, Nie Chang-Ming, Liao Li-Fu. Rational design of a nitrite reductase based on myoglobin: A molecular modeling and dynamics simulation study.J Mol Model,2012,18(9): 4409-4415..
34.Lin Ying-Wu*, Sun Mei-Hui, Dun Wan, Liao Li-Fu.Observation of heme transfer from cytochrome b5 to DNA aptamer.Spectrochimica Acta Part A,2012, 96(10):365-369.
33. Guo Wei-Wei, Wan Dun, Liao Li-Fu,Lin Ying-Wu*. Unusual peroxidase activity of a myoglobin mutant with two distal histidines.Chin Chem Lett,2012, 23(6): 741-744.
32. Wan Dun, Liao Li-Fu, Zhao Min-Min, Wu Min-Long, Wu Yi-Mou,Lin Ying-Wu*. Interactionsof uranyl ion with cytochromeb5 and its His39Ser variant as revealed by molecular simulation in combination with experimental methods.J Mol Model,2012, 18(3): 1009-1013.
31.Lin Ying-Wu*, Wu Yi-Mou, Liao Li-Fu, Nie Chang-Ming. Molecular modeling of cytochromeb5 with a single cytochromec-like thioether linkage.J Mol Model,2012, 18(4):1553-1560.
30.Lin Ying-Wu*, Wu Yi-Mou, Liao Li-Fu. Dynamics comparison of two myoglobins with a distinct heme active site.J Mol Model,2012, 18(4):1591-1596.
29.林英武*. 细胞色素b5－蛋白质相互作用研究.化学进展,2012, 24(4): 147-155.
28.林英武*. 计算机辅助蛋白质分子理性设计：从肌红蛋白到一氧化氮还原酶.化学进展,2012,24(5): 129-134.
27. Minmin Zhao, Lifu Liao*, Minlong Wu,Yingwu Lin, Xilin Xiao, Changming Nie. Double-receptor sandwich labeled supramolecule assay of ATP based on uranyl-salophen complex and aptamer.Biosens. Bioelectron.2012, 34: 106-111.
26. Minlong Wu, Lifu Liao*, Minmin Zhao,Yingwu Lin, Xilin Xiao, Changming Nie. Separation and determination of trace uranium using a double-receptor sandwich supramolecule method based on immobilized salophen and fluorescence labeled oligonucleotide.Analytica Chimica Acta,2012, 729: 80-84.
25. Zhiyuan Zhao, Lifu Liao*, Xilin Xiao, Nan Du,Yingwu Lin. Determination of uranium in water based on enzyme inhibition using a wireless magnetoelastic sensor.Intern. J. Environ. Anal. Chem.2012,DOI:10.1080/03067319.2011.649742.
24. Nan Du, Lifu Liao*, Yongjun Xiao, Xilin Xiao, Zhiyuan Zhao,Yingwu Lin, Changming Nie. Developing a wireless sensing method for the measurement of gamma radiation dose based on the polymerization of acrylamide.Radiation Measurements,2012, 47(5): 371-374.201123.Lin Ying-Wu*. Structural insights into a low-spin myoglobin variant with bis-His coordination from molecular modeling.Proteins,2011, 79(3): 679-684.
22.Lin Ying-Wu*, Nie Chang-Ming, Liao Li-Fu. Insights into uranyl ion binding to ubiquitin from molecular modeling and dynamics simulations.Chem Lett,2011,40(12):1330-1331.
21.Lin Ying-Wu*,Ying Tian-Lei, Liao Li-fu.Molecular modeling and dynamics simulation of a histidine-tagged cytochromeb5.J Mol Model, 2011, 17(5):971-978.
20.Lin Ying-Wu*, Liao Li-Fu. Probing interactions between uranyl ions and lipid membrane by molecular dynamics simulation.Comput Theo Chem,2011,976(1-3): 130-134.
19. Hayashi Takahiro, Miner Kyle D, Yeung Natasha,Lin Ying-Wu, Lu Yi, Moenne-Loccoz Pierre*. Spectroscopic characterization of mononitrosyl complexes in heme-nonheme diiron centers within the myoglobin scaffold (FeBMbs): relevance to denitrifying NO reductase.Biochemistry,2011, 50(26):5939-5947.201018.Ying-Wu Lin, Natasha Yeung, Yi-Gui Gao, Kyle D. Miner, Shiliang Tian, Howard Robinson, and Yi Lu*. Roles of glutamates and metal ions in a rationally designed nitric oxide reductase based on myoglobin.Proc Natl Acad Sci USA,2010, 107(19): 8581-8586.
17.Ying-Wu Lin, Natasha Yeung, Yi-Gui Gao, Kyle D. Miner, Lanyu Lei, Howard Robinson, and Yi Lu*. Introducing a non-heme iron center into myoglobin confers nitric oxide reductase activity.J Am Chem Soc, 2010, 132(29): 9970-9972.
16.林英武*. 蛋白质功能的扩展与人工金属结合位点的理性设计.化学进展,2010, 22(6): 1203-1211.200915. Natasha Yeung,Ying-Wu Lin, Yi-Gui Gao, Xuan Zhao, Brandy S. Russell, Lanyu Lei, Kyle D. Miner, Howard Robinson, and Yi Lu*. Rational design of a structural and functional nitric oxide reductase.Nature,2009, 462(7276): 1097-1082.
14.Lin Ying-Wu*,Nie Chang-Ming, Liao Li-Fu. Folding behaviors of apocytochromeb5 and its mutants: Insights from high temperature molecular dynamics simulations.J Mol Struct THEOCHEM,2009, 910(1-3): 154-162.
13.Lin Ying-Wu*,Ni Feng-Yun, Ying Tian-Lei. Early events in thermal unfolding of apocytochromeb562 and its double-cysteine mutant as revealed by molecular dynamics simulation.J Mol Struct THEOCHEM,2009, 898(1-3): 82-89.
12.Lin Ying-Wu*, Ying Tian-Lei, Liao Li-Fu. Dynamic consequences of mutating the typical HPGG motif of apocytochromeb5 revealed by computer simulation.Chin Chem Lett, 2009,20(5): 631-634.
11. Ying Tianlei, Wang Zhong-Hua,Lin Ying-Wu, Xie Jin, Tan Xiangshi*, Huang Zhongxian*. Tyrosine-67 in cytochromecis a possible apoptotic trigger controlled by hydrogen bonds via a conformational transition.Chem Commun,2009, 30: 4512-4514.200810.Lin Ying-Wu*, Wang Zhong-Hua, Ni Feng-Yun, Huang Zhong-Xian. Forced unfolding of apocytochromeb5 by steered molecular dynamics simulation.Protein J,2008, 27(3): 197-203.
9.Lin Ying-Wu*,Nie Chang-Ming, Liao Li-Fu.Probing the weak interactions between amino acids and carbon monoxide.Chin Chem Lett, 2008,19(1): 119-122.
8. Jintao Yuan, Lifu Liao,Yingwu Lin, Changai Deng, Bo He. Determination of Sudan I in chilli powder from components gradual change–visible spectra data using second order calibration algorithms.Analytica Chimica Acta,2008, 607(2): 160-167.
7.官墨蓝，王中华，林英武，黄仲贤。细胞色素b5S64X 突变体对蛋白结构及稳定性的影响，无机化学学报，2008, 24 (1): 47-54.　2007 and before6.林英武*，王中华，聂长明，倪峰云。取代基对卟吩结构和性能的影响，物理化学学报，2007, 23 (10), 1594-1598.
5. Wang Zhong-Hua,Lin Ying-Wu, Rosell Federico I., Ni Feng-Yu, Lu Hao-Jie, Yang Peng-Yuan, Tan Xiang-Shi, Li Xiao-Yuan, Huang Zhong-Xian*, Mauk A. Grant. Converting cytochromecinto a peroxidase-like metalloenzyme by molecular design.ChemBioChem,2007,8(6): 607-609.
4.林英武，黄仲贤。血红素蛋白的分子设计新趋向。化学进展，2006, 18 (6): 794-800.
3.Lin Ying-Wu, Zhao Dong-Xin, Wang Zhong-Hua, Yu Wen-Hao, Huang Zhong-Xian*. Expression of lipase-solubilized bovine liver microsomal cytochromeb5 inEscherichia colias a glutathione S-transferase fusion protein (GST-cytb5).Protein Express Purif,2006, 45(2): 352-358.
2.Lin Ying-Wu, Wang Wen-Hu. Zhang Qi. Lu Hao-Jie, Yang Peng-Yuan, Xie Yi, Huang Zhong-Xian*, Wu Hou-Ming*. Converting cytochromeb5 into cytochromec-like protein.ChemBioChem,2005, 6(8): 1356-1359.
1.Lin Y*, Zhang X, Li J, Yin D, Wang Y. Preparation and radiolabeling of antimony sulfide nanocolloids with two different particle sizes.Appl Radiat Isotop,2003, 58(3): 347-352.