标题：成莹
个人简介:
成莹，女，现任北京师范大学化学学院副院长，教授，博士生导师。
个人生平：
1961年4月出生。1983年7月毕业于复旦大学化学系获学士学位，1986年7月获复旦大学有机化学专业硕士学位。1986年8月进入北京师范大学化学系任教。1995年7月赴英国Sunderland大学攻读博士学位，师从著名杂环化学家Otto Meth-Cohn教授，1996年6月返回北京师范大学继续在职完成博士论文研究，1999年7月在英国Sunderland大学获理学博士学位。2000年7月受聘于北京师范大学化学系教授。2004年入选教育部“新世纪优秀人才支持计划”，2005年获国家自然科学基金委“杰出青年基金”资助，2006年入选“新世纪百千万人才工程”国家级人选。
研究方向：
成莹教授的研究方向为有机合成方法学和卡宾化学，目前的研究工作集中在杂原子取代卡宾的反应和应用、新颖多官能团杂环化合物新合成方法和具有生物活性的天然化合物及类似物全合成等方面。
主要成就：
在工作中，发现了N-杂环卡宾衍生的偶极内盐是高度位置选择性的两可性双1,3-偶极体，研究了两可性1,3-环加成的反应历程和反应规律；证明了新型卡宾中间体－氮氯取代卡宾的存在及其亲核反应性能；揭示了环状酰氨基卡宾和芳氧基氯代卡宾等两亲性卡宾在构建复杂螺杂环、桥杂环和稠杂环化合物中的应用价值。提出了由手性杂环烯胺合成多羟基氮稠杂环生物碱和类似物的新策略。建立与发展了合成非对称二芳环并[1,5]二氮芳辛类和双二氮芳辛类化合物的一步合成新途经；提出了碱催化下Friedel-Crafts酰基化反应合成各种N-烷基靛红的一步反应新方法。这些研究成果发表在Chem. Rev.、Chem. Eur. J.、Chem. Comm.、J. Org. Chem.等SCI收录的、国际有重要影响的学术期刊上。自1998年以来，主持国家自然科学基金、北京市自然科学基金和教育部科研基金等十余项。
主讲课程：
基础有机化学、高等有机化学
主持的主要科研项目：
· 国家自然科学基金面上项目（20672013）“ N- 杂环卡宾衍生的两可性 1,3- 偶极体化学研究－构建螺杂环的新策略”，2007.1-2009.12, 项目负责人。
· 国家自然科学基金“杰出青年基金”（20525207）， “有机合成反应”，2006.1-2009.12, 项目负责人。
· 教育部“新世纪优秀人才支持计划”（NCET-04-0143）， 2005.1-2007.12, 项目负责人。
· 国家自然科学基金面上项目（20472010），“手性杂环烯胺和多羟基氮稠杂环生物碱新合成方法研究”，2005.1-2007.12, 项目负责人。
· 北京市自然科学基金面上项目（2052013），“抗肿瘤、抗艾滋病的多羟基杂环生物碱新合成方法研究”，2005.1-2007.12, 项目负责人。
· 教育部科学技术研究重点项目（104014），“杂原子取代卡宾的反应性能及其在有机合成中的应用”，2004.1-2006.12, 项目负责人。
· 国家自然科学基金面上项目（20172009），“新型亲核卡宾－氮氯卡宾化学研究”，2002.1-2004.12, 项目负责人。
· 国家自然科学基金面上项目（29772003），“新颖的中等大小含氮杂环化合物的新合成方法研究”，1998.1-2001.12, 项目负责人。
代表性论文：
29. “Highly Site, Regio- and Stereoselective Multicomponent Reaction of Benzimidazole Carbenes, Isothiocyanates and Allenoates” 
Bo Wang, Jia-Qi Li, Ying Cheng*,
Tetrahedron Lett., 2008, 49, 485-489.
28. “The unprecedented ring transformation from thiazoline-spiro-thiophene to thieno[2,3-b]pyrazine involved in the reaction of 2-thiocarbamoyl thiazolium salts with dimethyl acetylenedicarboxylate”
Yang-Guang Ma and Ying Cheng*,
Chem. Commun., 2007, (47), 5087-5089.
27. “Substrate Controlled and Site Selective [3+2]-Cycloadditions of N-Heterocyclic Carbene Derived Ambident Dipoles”
Ying Cheng*, Mei-Fang Liu, De-Cai Fang* and Xue-Mei Lei, 
Chem. Eur. J., 2007, 13 (15), 4282-4292.
26. “Highly Efficient and Site Selective [3+2] Cycloaddition of Carbene-Derived Ambident Dipoles with Ketenes for a Straightforward Synthesis of Spiro-pyrrolidones” 
Jia-Qi Li, Rong-Zhen Liao, Wan-Jian Ding, and Ying Cheng*
J. Org. Chem., 2007, 72, 6266-6269.
25. “The Interaction of b-Lactam Carbenes with Aryl Isonitriles: an Unprecedented Rearrangement of 2-Azetidinonylidene Indoles to d-Carbolinones” 
Ying Cheng* and Lan-Qing Cheng
J. Org. Chem., 2007, 72 (7), 2625-2630.
24. “A Versatile Strategy for Divergent and Diastereoselective Synthesis of Natural Product-Like Polyhydroxylated Indolizidines”
Xiao-Ping Jiang, Ying Cheng*, Gao-Feng Shi, and Zhi-Mei Kang
J. Org. Chem., 2007, 72 (6), 2212-2215. 
23. “Reaction of b-lactam carbenes with alkyl isonitriles for a ready approach to 4-cyano and 4-carbamoyl substituted b-lactams”
Lan-Qing Cheng and Ying Cheng*
Tetrahedron, 2007, 63(38), 9359-9364.
22. “An Unprecedented Tandem 1,3-Dipolar Cycloaddition/Cheletropic Elimination: a Facial Approach to Novel Push-Pull Olefins” 
Qing Zhu, Mei-Fang Liu, Bo Wang and Ying Cheng*
Org. Biomol. Chem., 2007, 5, 1282-1286.
21. “A N-heterocyclic carbene derived highly regioselective ambident C-C-S and C-C-N 1,3-dipolar system” 
Mei-Fang Liu, Bo Wang and Ying Cheng*
Chem. Commun., 2006, 1215-1217. 
20.“High Nucleophilicity of Cyclic Amidocarbene toward Aryl Isocyanates, New Approach to Spiro[azetidinone-4,3’-indolinone] Derivatives”
Ying Cheng*, Bo Wang, and Lan-Qing Cheng
J. Org. Chem., 2006, 71 (12), 4418-4427.
19. “The Interaction of Aryloxychlorocarbenes with Acetylenedicarboxylate: Novel Formation of Polyfunctional Butadienes and 8-Oxatricyclo[3.2.1.02.4]oct-6-enes” 
Ying Cheng*, Qing Zhu, Quan Song Li, and Otto Meth-Cohn
J. Org. Chem., 2005, 70 (12), 4840-4846.
18.“Heterocycles derived from heteroatom-substituted carbenes”
Ying Cheng* and Otto Meth-Cohn*; 
Chem. Rev., 2004, 104 (5), 2507-2530.
17. “Heterocyclic Enamines: the Versatile Intermediates in the Synthesis of Heterocyclic Compounds and Natural Products”
Ying Cheng*, Zhi-Tang Huang and Mei-Xiang Wang*
Current Org. Chem., 2004, 8 (4), 325-350.
16. “A Simple One-Pot reaction to the Bis-dibenzo[b,f][1,5]diazocines: The Useful Precursors of Novel Macrocycles”
Ying Cheng*, Bo Wang, Otto Meth-Cohn
Synthesis, 2003, 18, 2839-2843.
15. “The surprising nucleophilic addition of aminochlorocarbenes to diethylacetylenedicarboxylate and to oxalyl chloride: Quinolines and benzo[1,4]diazepines from N-alkylformanilides and oxalyl chloride in the presence of Hunig’s base”
Ying Cheng*, Hua Yang and Otto Meth-Cohn* 
Org. Biomol. Chem., 2003, 1 (20), 3605-3610.
14.“The unique nucleophilic reactivity of arylaminochlorcarbenes” 
Ying Cheng*, Hua Yang, Otto Meth-Cohn*
Chem. Commun., 2003, 90-91.
13.“Synthetic applications of aminochlorocarbenes: a two-step conversion of N-methylformanilides into 3-arylamino-2-chloroindoles”
Ying Cheng*, Yu-Hua Zhan, Hai-Xia Guan, Otto Meth-Cohn*
Synthesis, 2002, 16, 2426-2430.
12. “Unexpected ring size effect of the annulation of heterocyclic secondary enamines with dicarboxylic acid dichlorides” 
Ying Cheng*, Hai-Bo Yang, Mei-Xiang Wang*, Davia J. Williams
Tetrahedron, 2002, 58, 2821-2829.
11. “A simple route to N-w-chloroalkylisatins from cyclic t-anilines, oxalyl chloride and DABCO”
Ying Cheng*, Yu-Hua Zhan, Otto Meth-Cohn*
Synthesis, 2002, 1, 34-38.
10. “A very simple route to benzonaphtho[1,5]diazocines using Vilsmeier reagents via the t-amino effect”
Ying Cheng*, Hai-Bo Yang, Bo Liu, Otto Meth-Cohn*, David Watkin, Stephen Humphries 
Synthesis, 2002, 7, 906-910.
9. “Annulation of heterocyclic secondary enamines with dicarboxylic acid dichlorides, an unexpected ring size effect”
Ying Cheng*, Hai-Bo Yang, Zhi-Tang Huang, Mei-Xiang Wang*
Tetrahedron Lett., 2001, 42, 1757-1759.
8. “A very simple route to methylisatins: Friedel-Crafts acylation of p-substituted N,N-dimethylanilines with oxalyl chloride and DABCO”
Ying Cheng*, Hai-Lin Ye, Yu-Hua Zhan, Otto Meth-Cohn*
Synthesis, 2001, 6, 904-908.
7. “Unexpected products from formylation of N,N-dimethylanilines with 2-formamidopyridine in POCl3”
Ying Cheng*, Peng Jiao, Davia J. Williams, Otto Meth-Cohn* 
J.C.S. Perkin Trans 1, 2001, 44-46.
6. “En route to Molecular Bracelets: The synthesis of linear pentacyclic bis-(benzodiazocino)benzenes.” 
Ying Cheng*, Qing-Xiang Liu and Otto Meth-Cohn*
Synthesis, 2000, 640-642.
5. “Surprising formylations with methylformamidopyridines and oxalyl chloride.”
Ying Cheng*, Qing-Xiang Liu and Otto Meth-Cohn*
Tetrahedron Lett., 2000, 41, 3475-3478.
4.“Vilsmeier formalytion of tert-anilines: dibenzo[b,f][1,5]diazocines and quinazolinium salts via the t-amino effect.” 
Ying Cheng, Otto Meth-Cohn* and David Taylor
J. C. S., Perkin Trans.1, 1998, 1257-1262.
3. “Umpoled Vilsmeier reagents. The chemistry of aminochlorocarbenes derived from Vilsmeier reagents by the action of bases.”
Ying Cheng, Simon Goon and Otto Meth-Cohn*
J. C. S., Perkin Trans.1, 1998, 1619-1625.
2. “Carbenes from Vilsmeier reagents by the action of bases in POCl3; the umpolung of Vilsmeier reagents”. 
Ying Cheng, Simon Goon and Otto Meth-Cohn* 
Chem. Commun., 1996, 1395-1396.
1. “The Vilsmeier Formylation of N-(4-Tolyl)pyrrolidine, -piperidine and -perhydroazepine: Further Examples of the t-Amino Effect”
Otto Meth-Cohn* and Ying Cheng
Tetrahedron Lett. 1996, 37, 2679-2682.