标题：古练权
个人简历
  [1]男，1942年2月生，药物化学、有机化学和化学生物学教授（二级）。1964年毕业于华中师范大学化学系，毕业后留校任教，1980年赴美国State University of New York at Albany化学系学习，1981年转入Oklahoma State University生化系任Research associate，1983年回国。1998年调入中山大学化学系，1992年任教授，1993年任博士生导师（国务院学位委员会批准）。现为中山大学药学院药物化学研究所所长。1986，1989，1993，1995和1998年又先后应邀赴美进行合作研究。1997年以后，多次应邀到香港科技大学、香港中文大学和香港理工大学讲学和合作研究。从1983年开始，一直进行有关药物化学、有机化学和化学生物学和的研究和教学。主持多项国家自然科学基金重点和面上项目，部省基金重大、重点和面上项目。在国内外重要刊物发表论文200多篇，专利15项(包括国内外专利)，著作4部。主持的化学专业本科《有机化学》课程于2004年被评选为国家级精品课程。现为中国化学会Chinese Chemical Letters 编委。
近期论著
1.《生物有机化学》（第一作者），高等教育出版社和施普林格出版社，1998。科技图书股份有限公司（台湾，繁体字版），2001。
2.《生物化学》（第一作者），高等教育出版社，2000。 21世纪教材系列, 获得2002年全国普通高等学校教材二等奖）。
3. 《有机化学》（第一作者），高等教育出版社，2008。
4. 《化学生物学》（第二作者），化工出版社，2006。
近期论文
（2004－2009）
1.         Isaindigotone Derivatives: A New Class of Highly Selective Ligands for Telomeric G-quadruplex DNA，J. Med. Chem., 2009, 52，2825-2835.
2.         5-N-Methylated Quindoline Derivatives as Telomeric G-Quadruplex Stabilizing Ligands: Effects of 5-N Positive Charge on Quadruplex Binding Affinity and Cell Proliferation,J. Med. Chem. 2008, 51, 6381- 6392.
3.         Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc by quindoline derivatives，J. Med. Chem. 2007, 50, 1465-1474.
4.         Synthesis and evaluation of quindoline derivatives as G-quadruplex inducing and stabilizing ligands and potential inhibitors of telomerase，J. Med. Chem. 2005, 48, 7315.
5.         Senesence and telomere shortening induced by novel potent G-quadruplex interactive agents, quindoline derivatives, in human cancer cell lines. Oncogene, 2006, 25, 503.
6.         Inhibition of myc promoter and telomerase activity and induction of delayed apoptosis by SYUIQ-5, a novel G-quadruplex interactive agent in leukemia cells, Leukemia, 2007, 1-3.
7.         G-quadruplexes: a target for anti-cancer drug design, ChemMedChem，2008, 3, 690-713. 
8.         Synthesis and evaluation of curcumin analogues as potential thioredoxin reductase inhibitors, Bioorg. Med. Chem., 2008, 16, 8035-8041.
9.         Synthesis, cytotoxic activities and structure-activity relationships of topoisomerase I inhibitors: Indolizinoquinoline-5,12-dione derivatives, Bioorg. Med. Chem. 2008, 16, 4617-4325.
10.     9-N-Substituted berberine derivatives: Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc, Bioorg. Med. Chem., 2008,16, 7582-7591.
11.     9-Substituted berberine derivatives as G-quadruplex stabilizing ligands in telomeric DNA, Bioorg. Med. Chem. 2007, 15, 5493-5501.
12.     Synthesis and evaluation of 9-O-substituted berberine derivatives containing aza-aromatic terminal group as highly selective telomeric G-quadruplex stabilizing ligands, Bioorg. Med. Chem.Lett, 2009, 19, 3414-3417.
13.     Synthesis and antimultidrug resistance evaluation of icariin and its derivatives, Bioorg. Med. Chem.Lett, 2009, 19, 4237-4240.
14.     Inhibition of thioredoxin reductase by curcumin analogs, Biosci. Biotech. Biochem., 2008, 72, 2214-2218.
15.     Design, synthesis and evaluation of isaindigotone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors, Bioorg. Med. Chem., 2008,16, 3790-3793.
16.     A Facile Synthesis of Novel Heteropolycyclic Pyrazines and Oxazoles Mechanistic Studies of 2,3-Dihydrobenzo[de]chromene-7,8-dione with Amines, Heterocycles, 2008, 75, 1773-1778.
17.     Oxoisoaporphine Alkaloid Derivatives: Synthesis, DNA Binding Affinity and Cytotoxicity, Eur. J. Med. Chem., 2008, 43, 973-980.
18.     Synergetic inhibition of metal ions and genistein on a-glucosidase，FEBS Letters, 2004, 576, 46-50.
19.     Derivatives of oxoisoaporphine alkaloids: A novel class of selective acetycholinesterase inhibitors, Bioorg. Med. Chem.Lett. 2007, 17, 3765-3768.
20.     Synergetic inhibition of genistein and a-glucose on a-glucosidase，Bioorg. Med. Chem.Lett. 2004, 14, 2947-2950.
21.     Synthesis of Zwitterionic 4-Hydroxycoumarin Derivatives through a Unique Reaction of 4-Hydroxycoumarins with p- Benzoquinone and Pyridine，Org. lett., 2004, 6, 4853.
22.     Novel synthesis of o-nephthothiophenequinone derivatives Regioselective via regioselective  Diels-Alder reaction, Terahedron, 2005, 61, 9097-9101.
23.     An intriguing reaction of 4-hydroxycoumarins with 2,3-dichloro-5,6-dicyanobenzoquinone，Tetrahedron, 2005, 61, 3087-3090.
24.     The unique regioselectivity in the formation of disubstituted-1,4-benzoquinones generated from the reaction of 4-hydroxycoumarins with 1,4-benzoquinone，Tetra. Lett. 2006, 47, 6757–6760.
25.     Facile preparation of new unsymmetrical curcumin derivatives by solid-phase synthesis strategy，Tetra. Lett. 2006, 47, 4085-4089.
26.     One-pot synthesis of 5,6-dihydroxylated benzo[b]furan derivatives，Tetra. Lett. 2006, 47, 2615-2618.
27.     Synthesis of novel dihydrofuro [b] pyridinone derivatives : oxidation coupling of 3-hydroxy-4(1H)-pyridinone with β-dicarbonyl compounds，Tetra. Lett. 2005, 46, 5085-5088.
28.     Oxoisoaporphine alkaloid derivatives:synthesis, DNA bimding affinity and cytotoxicity, Eur. J. Med. Chem，2007, 42, ，in Press, corrected Proof, Available online.
29.     Spectroscopic studies of DNA binding modes of cation-substituted anthrapyrazoles derived from emodin, Eur. J. Med. Chem，2007, 42, 1169-1175.
30.     Synthesis, DNA binding and cytotoxity of new pyrazole emodin derivatives，Eur. J. Med. Chem. 2006, 41, 1041-1047.
31.     a-Glucosidase inhibition of natural curcuminoids and curcumin analogs,Eur. J. Med. Chem. 2006, 41, 213-218.
32.     Synthesis and biological evaluation of functionalized coumarins as acetycholinesterase inhibitors，Eur. J. Med. Chem. 2005, 40, 1307-1315.
33.     The Molecular Mechanisms Involved in the Cytotoxicity of Alkannin DerivativesEur. J. Med. Chem. 2005, 40, 1341-1345.
34.     Synthesis and Cytotoxicity Study of Alkannin Derivatives，Eur. J. Med. Chem. 2004, 39, 755-764.
35.     Apoptosis-inducing activity of new pyrazole emodin derivatives in Human Hepatocellular Carcinoma HepG2 cells, Biol. Pharm. Bull. 2007,30, 1113-1116.
36.     Synthesis and Cytotoxicity of 9-Substitued benzo[de]chromene-7,8-dione and 5-benzyl-9-Substitued benzo[de]chromene-7,8-dione，Synthesis Comm. 2006, 17, 769-772.