标题：张辰宇
概述
详情张辰宇教授
长江特聘教授, 博士生导师，南京大生命科学学院院长。荣誉成就1991-1995年 日本德岛大学医学部 博士 
1995-1999年 美国哈佛大学医学院 博士后 
1999-2004年 美国哈佛大学医学院 研究助理教授(分子糖尿病学) 
2001-2003年 南京大学生命科学学院 部分时教授
2003-现在 南京大学生命科学学院 全时教授，院长，
1993年度 日本学术振兴会特别研究员奖 
2002年度 美国糖尿病学会青年学者奖。 
2003年度 中国国家自然科学基金委杰出青年基金。
基本信息
姓 　名 张辰宇 
性 　别 男 
出生年月 1966.10 
最终学历 研究生 
职 　称 教授（长江学者） 
学 　位 博 士
职 　务 院 长 
所在院系 生命科学学院 
研究方向 生理学、分子生物学
张辰宇介绍
张辰宇，男，39岁，博士，南京大学教授，长江特聘教授, 博士生导师，南大生科院院长。  91-95年 日本德岛大学医学部 博士 95-99年 美国哈佛大学医学院 博士后 99-04年 美国哈佛大学医学院 研究助理教授(分子糖尿病学) 01-03年 南京大学生命科学学院 部分时教授， 03-现在 南京大学生命科学学院 全时教授，院长， 93年度 日本学术振兴会特别研究员奖 02年度 美国糖尿病学会青年学者奖。 03年度 中国国家自然科学基金委杰出青年基金。 主要从事身体的能量代谢及细胞的能量代谢的分子作用机理及与之相关的疾病，如肥胖，糖尿病的发病机理方面的研究。在研究中发现了UCP2 及O2--UCP2途径导致2型糖尿病的新的发病机理。其间，也曾系统性地研究了PGC-1a的功能。还发现了BAD与GK在线粒体上形成复合物，第一次把细胞凋亡与细胞的糖代谢联系在一起。论文在Cell, Nature, Science, JCI, Mol.Cell, PNAS,等杂志上发表40余篇。发表文章的总引用次数达2500次。张辰宇教授在糖尿病的基础研究方面有很好的研究基础。在本项目中主要协调各课题组涉及到的糖尿病的基础研究，包括分子生物学、细胞生物学和模式生物研究等。
研究方向
张辰宇教授主要从事身体的能量代谢及细胞的能量代谢的分子作用机理及与之相关的疾病，如肥胖，糖尿病的发病机理方面的研究。在研究中发现了UCP2 及O2--UCP2途径导致2型糖尿病的新的发病机理。其间，也曾系统性地研究了PGC-1a的功能。还发现了BAD与GK在线粒体上形成复合物，第一次把细胞凋亡与细胞的糖代谢联系在一起。论文在Cell, Nature, Science, JCI, Mol.Cell, PNAS,等杂志上发表40余篇。发表文章的总引用次数达2500次。张辰宇教授在糖尿病的基础研究方面做了大量的研究工作，有很好的研究基础。
教学情况
近五年讲授的主要课程
生理学：学科核心课程，生命科学学院生物制药专业，4学时/周，2004级1届学生，约80人。
学术研究
主要研究一、近五年来承担的学术研究课题
1. 2型糖尿病的发生发展分子机制的研究。国家科技部“973”项目，2006-2011年，首席科学家。
2. 2型糖尿病临床干细胞应用的研究。国家科技部“863”项目，2006 -2011年，首席科学家。
3. 内分泌学与代谢病。国家自然科学基金杰出青年基金，2003-2006年，项目负责人。
二、近五年来发表的学术论文研究成果代表性文章：　
1. Krauss S, Zhang CY, Lowell BB. The Mitochondrial Uncoupling Protein Homologues. Nature Reviews Molecular Cell Biology, 6(3):248-61, 2005.
2. Balthasar N, Dalgaard LT, Lee CE, Yu J, Funahashi H, Williams T, Ferreira M, Tang V, McGovern RA, Kenny CD, Christiansen LM, Edelstein E, Choi B, Boss O, Aschkenasi C, Zhang CY, Mountjoy K, Kishi T, Elmquist JK, Lowell BB. Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell, 123(3):493-505,2005.
3. Zhang CY, Parton LE, Ye CP, Krauss S, Shen R, Lin CT, Porco JA Jr, Lowell BB. Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets. Cell Metabolism, 3(6):417-27, 2006.
4. Parton LE, Ye CP, Coppari R, Enriori PJ, Choi B, Zhang CY, Xu C, Vianna CR, Balthasar N, Lee CE, Elmquist JK, Cowley MA, Lowell BB.Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity. Nature, 449(7159):228-32, 2007. 
5. Danial NN, Walensky LD, Zhang CY, Choi CS, Fisher JK, Molina AJ, Datta SR, Pitter KL, Bird GH, Wikstrom JD, Deeney JT, Robertson K, Morash J, Kulkarni A, Neschen S, Kim S, Greenberg ME, Corkey BE, Shirihai OS, Shulman GI, Lowell BB, Korsmeyer SJ.Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nature Medicine, 14(2):144-53, 2008.
回国后发表的文章：
*1. Chen X, Ba Y, Ma L, Cai X, Yin Y, Wang K, Guo J, Zhang Y, Chen J, Guo X, Li Q, Li X, Wang W, Zhang Y, Wang J, Jiang X, Xiang Y, Xu C, Zheng P, Zhang J, Li R, Zhang H, Shang X, Gong T, Ning G, Wang J, Zen K, Zhang J, Zhang CY.Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res. 2008 Oct;18(10):997-1006. 
*2. Zhang Y, Liu D, Chen X, Li J, Li L, Bian Z, Sun F, Lu J, Yin Y, Cai X, Sun Q, Wang K, Ba Y, Wang Q, Wang D, Yang J, Liu P, Xu T, Yan Q, Zhang J, Zen K, Zhang CY. Secreted monocytic miR-150 enhances targeted endothelial cell migration. Mol Cell. 2010 Jul 9;39(1):133-44. 
*3. Zhang L, Hou D, Chen X, Li D, Zhu L, Zhang Y, Li J, Bian Z, Liang X, Cai X, Yin Y, Wang C, Zhang T, Zhu D, Zhang D, Xu J, Chen Q, Ba Y, Liu J, Wang Q, Chen J, Wang J, Wang M, Zhang Q, Zhang J, Zen K, Zhang CY. Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA. Cell Res. 2012 Jan;22(1):107-26. 
*4. Chen X, Gao C, Li H, Huang L, Sun Q, Dong Y, Tian C, Gao S, Dong H, Guan D, Hu X, Zhao S, Li L, Zhu L, Yan Q, Zhang J, Zen K, Zhang CY. Identification and characterization of microRNAs in raw milk during different periods of lactation, commercial fluid, and powdered milk products. Cell Res. 2010 Oct;20(10):1128-37. 
*5. Wang C, Yang C, Chen X, Yao B, Yang C, Zhu C, Li L, Wang J, Li X, Shao Y, Liu Y, Ji J, Zhang J, Zen K, Zhang CY, Zhang C. Altered profile of seminal plasma microRNAs in the molecular diagnosis of male infertility. Clin Chem. 2011 Dec;57(12):1722-31. 
*6. Hu Z, Chen X, Zhao Y, Tian T, Jin G, Shu Y, Chen Y, Xu L, Zen K, Zhang CY, Shen H. Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer. J Clin Oncol. 2010 Apr 1;28(10):1721-6. 
*7. Li LM, Hu Z, Zhou ZX, Chen X, Liu FY, Zhang JF, Shen HB, Zhang CY, Zen K. Serum microRNA profiles serve as novel biomarkers for HBV infection and diagnosis of HBV-positive hepatocarcinoma. Cancer Res. 2010 Dec 1;70(23):9798-807.
*8. Zen K, Zhang CY. Circulating MicroRNAs: a novel class of biomarkers to diagnose and monitor human cancers. Med Res Rev. Epub 2010 Nov 9. 
*9. Chen X, Liang H, Zhang J, Zen K, Zhang CY. Secreted microRNAs: a new form of intercellular communication. Trends Cell Biol. Trends Cell Biol. Epub 2012 Jan 17. 
*10. Chen X, Guo X, Zhang H, Xiang Y, Chen J, Yin Y, Cai X, Wang K, Wang G, Ba Y, Zhu L, Wang J, Yang R, Zhang Y, Ren Z, Zen K, Zhang J, Zhang CY. Role of miR-143 targeting KRAS in colorectal tumorigenesis.   Oncogene. 2009 Mar 12;28(10):1385-92. 
11. Chen X, Liang H, Zhang J, Zen K, Zhang CY. Horizontal transfer of microRNAs: molecular mechanisms and clinical applications.Protein Cell. 2012 Jan;3(1):28-37. 
12. Liu R, Chen X, Du Y, Yao W, Shen L, Wang C, Hu Z, Zhuang R, Ning G, Zhang C, Yuan Y, Li Z, Zen K, Ba Y, Zhang CY. Serum MicroRNA Expression Profile as a Biomarker in the Diagnosis and Prognosis of Pancreatic Cancer. Clin Chem. Clin Chem. Epub 2011 Dec 22.
13. Chen X, Hu Z, Wang W, Ba Y, Ma L, Zhang C, Wang C, Ren Z, Zhao Y, Wu S, Zhuang R, Zhang Y, Hu H, Liu C, Xu L, Wang J, Shen H, Zhang J, Zen K, Zhang CY. Identification of ten serum microRNAs from a genome-wide serum microRNA expression profile as novel noninvasive biomarkers for nonsmall cell lung cancer diagnosis.Int J Cancer. 2012 Apr 1;130(7):1620-8. 
14. Wang K, Li P, Dong Y, Cai X, Hou D, Guo J, Yin Y, Zhang Y, Li J, Liang H, Yu B, Chen J, Zen K, Zhang J, Zhang CY, Chen X. A microarray-based approach identifies ADP ribosylation factor-like protein 2 as a target of microRNA-16. J Biol Chem. J Biol Chem. 2011 Mar 18;286(11):9468-76.
15. Liu R, Zhang C, Hu Z, Li G, Wang C, Yang C, Huang D, Chen X, Zhang H, Zhuang R, Deng T, Liu H, Yin J, Wang S, Zen K, Ba Y, Zhang CY. A five-microRNA signature identified from genome-wide serum microRNA expression profiling serves as a fingerprint for gastric cancer diagnosis.Eur J Cancer. 2011 Mar;47(5):784-91.
16. Xie L, Wang T, Yu S, Chen X, Wang L, Qian X, Yu L, Ding Y,Zhang CY, Liu B. Cell-free miR-24 and miR-30d, potential diagnostic biomarkers in malignant effusions.Clin Biochem. 2011 Feb;44(2-3):216-20.
17. Zhang C, Wang C, Chen X, Yang C, Li K, Wang J, Dai J, Hu Z, Zhou X, Chen L, Zhang Y, Li Y, Qiu H, Xing J, Liang Z, Ren B, Yang C, Zen K, Zhang CY. Expression profile of microRNAs in serum: a fingerprint for esophageal squamous cell carcinoma. Clin Chem. 2010 Dec;56(12):1871-9. 
18. Xie L, Chen X, Wang L, Qian X, Wang T, Wei J, Yu L, Ding Y, Zhang CY, Liu B. Cell-free miRNAs may indicate diagnosis and docetaxel sensitivity of tumor cells in malignant effusions. BMC Cancer. 2010 Oct 28;10:591.
19. Guo J, Dong Q, Fang Z, Chen X, Lu H, Wang K, Yin Y, Cai X, Zhao N, Chen J, Zen K, Zhang J, Zhang CY. Identification of miRNAs that are associated with tumor metastasis in neuroblastoma. Cancer Biol Ther. 2010 Mar;9(6): 446-52. 
20. Chen X, Li Q, Wang J, Guo X, Jiang X, Ren Z, Weng C, Sun G, Wang X, Liu Y, Ma L, Chen JY, Wang J, Zen K, Zhang J,Zhang CY. Identification and characterization of novel amphioxus microRNAs by Solexa sequencing. Genome Biol. 2009;10(7):R78.
21. Li S, Chen X, Zhang H, Liang X, Xiang Y, Yu C, Zen K, Li Y, Zhang CY. Differential expression of microRNAs in mouse liver under aberrant energy metabolic status. J Lipid Res. 2009 Sep;50(9):1756-65.
22. Chen X, Wang K, Chen J, Guo J, Yin Y, Cai X, Guo X, Wang G, Yang R, Zhu L, Zhang Y, Wang J, Xiang Y, Weng C, Zen K, Zhang J, Zhang CY. In vitro evidence suggests that miR-133a-mediated regulation of uncoupling protein 2 (UCP2) is an indispensable step in myogenic differentiation. J Biol Chem. 2009 Feb 20;284(8):5362-9. 
23. Zhang H, Li J, Liang X, Luo Y, Zen K, Zhang CY. Uncoupling Protein 2 Negatively Regulates Glucose-Induced Glucagon-Like Peptide-1 (GLP-1) Secretion. J Mol Endocrinol. 2012 Jan 18.
24. Xu W, Guo T, Zhang Y, Jiang X, Zhang Y, Zen K, Yu B, Zhang CY. The inhibitory effect of dexamethasone on platelet-derived growth factor-induced vascular smooth muscle cell migration through up-regulating PGC-1α expression. Exp Cell Res. 2011 May 1;317(8):1083-92.
25. Gu Z, Li J, Gao S, Gong M, Wang J, Xu H, Zhang CY, Wang J. InterMitoBase: an annotated database and analysis platform of protein-protein interactions for human mitochondria. BMC Genomics. 2011 Jun 30;12:335.
26. Gong M, Li J, Wang M, Wang J, Zen K, Zhang CY. The evolutionary trajectory of mitochondrial carrier family during metazoan evolution. BMC Evol Biol. 2010 Sep 16;10:282.
27. Xu W, Hou D, Jiang X, Lu Z, Guo T, Liu Y, Wang D, Zen K, Yu B, Zhang CY. The protective role of peroxisome proliferator-activated receptor γ coactivator-1α in hyperthyroid cardiac hypertrophy.J Cell Physiol. 2011 Nov 21. doi: 10.1002/jcp.24015.
28. Zhang D, Shen M, Mikita A, Zhang W, Liu Y, Liu Q, Dai Y,Zhang CY, Zheng S, Zheng XX. Targeting Uncoupling Protein-2 Improves Islet Graft Function. Cell Transplant.2011;20(3):421-9.
29. Sun LB, Zhang Y, Wang Q, Zhang H, Xu W, Zhang J, Xiang J, Li QG, Xiang Y, Wang DJ, Zhang CY. Serum palmitic acid-oleic acid ratio and the risk of coronary artery disease: a case-control study. J Nutr Biochem. 2011 Apr;22(4):311-7.
30. Chen K, Sun G, Lv Z, Wang C, Jiang X, Li D, Zhang CY. Molecular cloning of amphioxus uncoupling protein and assessment of its uncoupling activity using a yeast heterologous expression system. Biochem Biophys Res Commun. 2010 Oct 1;400(4):701-6.
31. Yang J, Li JH, Wang J,Zhang CY. Molecular modeling of BAD complex resided in a mitochondrion integrating glycolysis and apoptosis. J Theor Biol. 2010 Sep 21;266(2):231-41. 
32. Zhu L, Wang Q, Zhang L, Fang Z, Zhao F, Lv Z, Gu Z, Zhang J, Wang J, Zen K, Xiang Y, Wang D, Zhang CY. Hypoxia induces PGC-1α expression and mitochondrial biogenesis in the myocardium of TOF patients. Cell Res. 2010 Jun;20(6):676-87. 
33. Jiang X, Zhang Y, Hou D, Zhu L, Xu W, Ding L, Qi X, Sun G, Liu C, Zhang J, Zen K, Xiang Y, Zhang CY. 17beta-estradiol inhibits oleic acid-induced rat VSMC proliferation and migration by restoring PGC-1alpha expression. Mol Cell Endocrinol. 2010 Feb 5;315(1-2):74-80.
34. Wang C, Sun G, Chen K, Lv Z, Peng S, Jiang X, Xiang Y,Zhang CY. Molecular cloning of lamprey uncoupling protein and assessment of its uncoupling activity using a yeast heterologous expression system. Mitochondrion. 2010 Jan;10(1):54-61.
35. Zhu L, Sun G, Zhang H, Zhang Y, Chen X, Jiang X, Jiang X, Krauss S, Zhang J, Xiang Y, Zhang CY. PGC-1alpha is a key regulator of glucose-induced proliferation and migration in vascular smooth muscle cells. PLoS One. 2009;4(1):e4182.
36. Qu A, Jiang C, Xu M, Zhang Y, Zhu Y, Xu Q, Zhang CY, Wang X. PGC-1alpha attenuates neointimal formation via inhibition of vascular smooth muscle cell migration in the injured rat carotid artery. Am J Physiol Cell Physiol. 2009 Sep;297(3):C645-53. 
37. Luo Y, Zhu W, Jia J, Zhang CY, Xu Y. NMDA receptor dependent PGC-1alpha up-regulation protects the cortical neuron against oxygen-glucose deprivation/reperfusion injury. J Mol Neurosci. 2009 Sep;39(1-2):262-8.
38. Jin X, Yang YD, Chen K, Lv ZY, Zheng L, Liu YP, Chen SH, Yu CH, Jiang XY, Zhang CY, Li YM. HDMCP uncouples yeast mitochondrial respiration and alleviates steatosis in L02 and hepG2 cells by decreasing ATP and H2O2 levels: a novel mechanism for NAFLD. J Hepatol. 2009 May;50(5):1019-28. 
39. Zhang Y, Liu C, Zhu L, Jiang X, Chen X, Qi X, Liang X, Jin S, Zhang P, Li Q, Wang D, Liu X, Zeng K, Zhang J, Xiang Y, Zhang CY. PGC-1alpha inhibits oleic acid induced proliferation and migration of rat vascular smooth muscle cells. PLoS One. 2007 Nov 7;2(11):e1137.
40. Zhang Y, Ba Y, Liu C, Sun G, Ding L, Gao S, Hao J, Yu Z, Zhang J, Zen K, Tong Z, Xiang Y, Zhang CY. PGC-1alpha induces apoptosis in human epithelial ovarian cancer cells through a PPARgamma-dependent pathway. Cell Res. 2007 Apr;17(4):363-73.