标题：间苯二甲腈
简介
间苯二甲腈
英文名称: isophthalonitrile；1,3-dicyanobenzene,m-phthalodinitrile
CAS: 626-17-5
分子式：C8H4N2
分子量：128.13
性状：
白色针状晶体(乙醇中)或粉末。
沸点(°C) 282
熔点(°C) 161.5
比重 1.27（25℃）
溶于苯、乙醚、热乙醇和氯仿，微溶于水，不溶于轻油。
制取方法：
由间二甲苯在催化剂存在下进行气相氨氧化反应制得。
用途：
用于制取塑料、合成纤维、农药(百菌清)以及环氧树脂固化剂等。
是制农药百菌清和防腐剂的原料，也用于制聚氨酯树脂和环氧树脂的固化剂。
包装：25公斤/塑编袋。
储运：贮存于阴凉、通风、干燥处，按一般化学品运输。
物质毒性
编号毒性类型测试方法测试对象使用剂量毒性作用1acute Oral Rodent - rat 860 mg/kg 1.行为毒性Behavioral - convulsions or effect on seizure threshold2.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - dyspnea3.营养和代谢系统毒性Nutritional and Gross Metabolic - body temperature decrease2acute Inhalation Rodent - rat >8970 mg/m3/1H 1.Details of toxic effects not reported other than lethal dose value3acute Administration onto the skin Rodent - rat >5 mg/kg 1.Details of toxic effects not reported other than lethal dose value4acute Intraperitoneal Rodent - rat 520 mg/kg 1.眼毒性Sense Organs and Special Senses (Eye) - ptosis2.行为毒性Behavioral - muscle weakness3.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - acute pulmonary edema5acute Unreported Rodent - rat 1708 mg/kg 1.Details of toxic effects not reported other than lethal dose value6acute Oral Rodent - mouse 178 mg/kg 1.Details of toxic effects not reported other than lethal dose value7acute Intraperitoneal Rodent - mouse 450 mg/kg 1.行为毒性Behavioral - convulsions or effect on seizure threshold8acute Unreported Rodent - mouse 548 mg/kg 1.Details of toxic effects not reported other than lethal dose value9acute Oral Mammal - cat 500 mg/kg 1.Details of toxic effects not reported other than lethal dose value10acute Oral Rodent - rabbit 250 mg/kg 1.Details of toxic effects not reported other than lethal dose value11acute Administration onto the skin Rodent - rabbit >2 mg/kg 1.Details of toxic effects not reported other than lethal dose value12acute Unreported Rodent - rabbit 350 mg/kg 1.Details of toxic effects not reported other than lethal dose value13acute Unreported Rodent - guinea pig 370 mg/kg 1.Details of toxic effects not reported other than lethal dose value14MutipleDose Oral Rodent - rat 5250 mg/kg/1W-I 1.行为毒性Behavioral - food intake (animal)2.营养和代谢系统毒性Nutritional and Gross Metabolic - weight loss or decreased weight gain3.慢性病相关毒性Related to Chronic Data - death15MutipleDose Oral Rodent - rat 4050 mg/kg/30D-I 1.行为毒性Behavioral - food intake (animal)2.肝毒性Liver - changes in liver weight3.营养和代谢系统毒性Nutritional and Gross Metabolic - weight loss or decreased weight gain16MutipleDose Inhalation Rodent - rat 1250 mg/m3/6H/2W-I 1.胃肠道毒性Gastrointestinal - hypermotility, diarrhea2.皮肤和附件毒性Skin and Appendages - hair3.营养和代谢系统毒性Nutritional and Gross Metabolic - weight loss or decreased weight gain17MutipleDose Oral Rodent - rat 2475 mg/kg/99D-I 1.肝毒性Liver - other changes2.肝毒性Liver - changes in liver weight3.肾、输尿管和膀胱毒性Kidney, Ureter, Bladder - urine volume increased18MutipleDose Oral Rodent - mouse 13500 mg/kg/90D-I 1.大脑毒性Brain and Coverings - changes in brain weight2.肝毒性Liver - changes in liver weight3.慢性病相关毒性Related to Chronic Data - changes in ovarian weight19MutipleDose Oral Rodent - mouse 5250 mg/kg/35D-C 1.肝毒性Liver - other changes2.肝毒性Liver - changes in liver weight20MutipleDose Oral Rodent - rabbit 4550 mg/kg/26W-I 1.肝毒性Liver - liver function tests impaired2.肝毒性Liver - other changes3.血液毒性Blood - pigmented or nucleated red blood cells21SkinEyeIrrition Administration into the eye Rodent - rabbit 500 mg/24H 1.Mild[1-10]