标题：吴世华
学 历
1994.9-1998  浙江大学副教授吴世华[1].7昆明理工大学环境工程与化学工程系精细化工专业，工学学士
1998.9-2001.3 昆明理工大学生物与化学工程学院应用化学专业，工学硕士
2001.3-2004.3浙江大学理学院化学系有机化学专业,，理学博士
工作经历
2004.4-2006.12浙江大学生命科学学院，讲师
2006.12-现在 浙江大学生命科学学院，副教授
工作研究领域
天然产物是新药研究的重要来源。迄今为止，几乎一半以上的临床抗癌药物和抗感染药物都是来自天然产物。近年来，随着基因组学、蛋白组学和代谢组学以及系统生物学的快速发展，天然产物的研究迎来了新的历史性机遇，发现和发展新的天然产物及其分离制备方法，揭示其新的作用机制和应用价值成为当前研究的一大热点。工作主要集中于：抗肿瘤天然产物（生物毒素）的提取分离、结构鉴定、作用机制及其应用研究；天然产物在癌症预防中的作用及机制；中药配伍机制在天然抗肿瘤先导化合物优化中的应用（即组合的研究策略用于癌症）；特殊生物资源的高效利用和开发。我们试图通过新的高效逆流色谱及相关色谱技术，分离和鉴定一些结构新颖的具有抗肿瘤活性的天然产物（生物毒素）；通过代谢组学和蛋白质组学等方法发现一些具有潜在药物价值的天然产物；通过上游和下游的细胞生物学激活或抑制，发现一些天然产物的新的作用通路，为天然产物的抗肿瘤应用奠定基础。
近年来，主持承担国家自然科学基金、浙江省自然基金及企业横向项目等多项课题的研究，在国内外发表相关论文二十余篇，申请和授权各类专利10余项。
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主要相关论文
1. Wu DF, Jiand XH,Wu SH*, Direct purification oftanshinonesfromSalvia miltiorrhizaBungeby high-speed counter-current chromatography without presaturation of the two-phase solvent mixture,Journal of Separation Science, 2009,accepted.
2. Yang L, Wu DF, Luo KW,Wu SH*, Wu P. Andrographolide enhances 5-fluorouracil-induced apoptosis via caspase-8-dependent mitochondrial pathway involving p53 participation in hepatocellular carcinoma (SMMC-7721) cells. Cancer Letters 2009;276(2):180-8.
3. F.Y. Liu, K.W. Luo, Z.M. Yu, N.N. Co,S.H. Wu,P. Wu, K.P. Fung, T.T. Kwok, Suillin from the mushroom Suillus placidus as potent apoptosis inducer in human hepatoma HepG2 cells. Chemico-Biological Interactions 181 (2009) 168-174.
4.Wu SH*,Yang L, Gao YA, Liu XY, Liu FY. Multi-channel counter-current chromatography for high-throughput fractionation of natural products for drug discovery. Journal of Chromatography A 2008;1180(1-2):99-107.
5. Wang TT, Jiang XH, Yang L,Wu SH*. pH-gradient counter-current chromatography isolation of natural antioxidant chlorogenic acid from Lonicera japonica Thumb. using an upright coil planet centrifuge with three multi-layer coils connected in series. Journal of Chromatography A 2008;1180(1-2):53-8.
6. Yang L,Wu SH*,Zhang QH, Liu F, Wu P. 23,24-Dihydrocucurbitacin B induces G(2)/M cell-cycle arrest and mitochondria-dependent apoptosis in human breast cancer cells (Bcap37). Cancer Letters 2007;256:267-78.
7. Ren G, Yu ZM, Chen YL,Wu SH, Fu CX.Sesquiterpene lactones from Saussurea alata. Natural Product Research 2007;21(3):221-6.
8. Qi Xiaopeng，Wu Zhongchang, Li Jinhui, Mo Xiaorong,Wu Shihua, Chu Jun, Wu Ping. AtCYT-INV1, a neutral invertase, is involved in osmotic stress-induced inhibition on lateral root growth in Arabidopsis. Plant Molecular Biology 2007;64(5):575-87.
9. Zhou H, Zheng ZG,Wu SH, Tai YP, Cao XJ, Pan YJ. Separation and characterization of clindamycin and related impurities in bulk drug by high-performance liquid chromatography-electrospray tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 2006;41(4):1116-23.
10.Wu SH, Tai YP, Pan YJ, Sun CR. Effect of gravitational force on type-J counter-current chromatography by mathematical analysis. Journal of Chromatography A 2006;1103(2):243-7.
11. Liu FY,Wu SH, Chen YL, Yang L, Wu P. Verticillin chloroform solvate. Acta Crystallographica Section E-Structure Reports Online 2006;62:O974-O6.
12.Wu SH, Sun CR, Pan YJ. Preparative counter-current chromatography purification of valrubicin (AD-32) from crude synthetic drug using upright coil planet centrifuge with four multilayer coils connected in series. Journal of Chromatography A 2005;1076(1-2):207-11.
13.Wu SH, Sun CR, Wang KW, Pan YJ. Preparative isolation and purification of celastrol from Celastrus orbiculatus Thunb. by a new counter-current chromatography method with an upright coil planet centrifuge. Journal of Chromatography A 2004;1028(1):171-4.
14.Wu SH, Sun CR, Pei SF, Lu YB, Pan YJ. Preparative isolation and purification of amides from the fruits of Piper longum L. by upright counter-current chromatography and reversed-phase liquid chromatography. Journal of Chromatography A 2004;1040(2):193-204.
15.Wu SH,Sun CR, Cao XJ, Zhou H, Zhang H, Pan YJ. Preparative counter-current chromatography isolation of liensinine and its analogues from embryo of the seed of Nelumbo nucifera GAERTN. using upright coil planet centrifuge with four multilayer coils connected in series. Journal of Chromatography A 2004;1041(1-2):153-62.