# The Comparative Toxicogenomics Database (CTD) - http://ctdbase.org/ # Copyright 2002-2012 MDI Biological Laboratory. All rights reserved. # Copyright 2012-2023 NC State University. All rights reserved. # # # Use is subject to the terms set forth at http://ctdbase.org/about/legal.jsp # These terms include: # # 1. All forms of publication (e.g., web sites, research papers, databases, # software applications, etc.) that use or rely on CTD data must cite CTD. # Citation guidelines: http://ctdbase.org/about/publications/#citing # # 2. All electronic or online applications must include hyperlinks from # contexts that use CTD data to the applicable CTD data pages. # Linking instructions: http://ctdbase.org/help/linking.jsp # # 3. You must notify CTD, and describe your use of our data: # http://ctdbase.org/help/contact.go # # 4. For quality control purposes, you must provide CTD with periodic # access to your publication of our data. # # More information: http://ctdbase.org/downloads/ # # Report created: Fri Oct 27 12:42:19 EDT 2023 # # Fields: # PathwayName PathwayID # 2-LTR circle formation REACT:R-HSA-164843 2-Oxocarboxylic acid metabolism KEGG:hsa01210 5-Phosphoribose 1-diphosphate biosynthesis REACT:R-HSA-73843 Abacavir metabolism REACT:R-HSA-2161541 Abacavir transmembrane transport REACT:R-HSA-2161517 Abacavir transport and metabolism REACT:R-HSA-2161522 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway REACT:R-HSA-73930 ABC-family proteins mediated transport REACT:R-HSA-382556 ABC transporter disorders REACT:R-HSA-5619084 ABC transporters KEGG:hsa02010 ABC transporters in lipid homeostasis REACT:R-HSA-1369062 Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate REACT:R-HSA-2978092 Abortive elongation of HIV-1 transcript in the absence of Tat REACT:R-HSA-167242 Acetylation REACT:R-HSA-156582 Acetylcholine Binding And Downstream Events REACT:R-HSA-181431 Acetylcholine Neurotransmitter Release Cycle REACT:R-HSA-264642 Acetylcholine regulates insulin secretion REACT:R-HSA-399997 Acrosome Reaction REACT:R-HSA-1300645 Activated NOTCH1 Transmits Signal to the Nucleus REACT:R-HSA-2122948 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 REACT:R-HSA-5625886 Activated point mutants of FGFR2 REACT:R-HSA-2033519 activated TAK1 mediates p38 MAPK activation REACT:R-HSA-450302 Activated TLR4 signalling REACT:R-HSA-166054 Activation and oligomerization of BAK protein REACT:R-HSA-111452 Activation, myristolyation of BID and translocation to mitochondria REACT:R-HSA-75108 Activation of AKT2 REACT:R-HSA-165158 Activation of AMPA receptors REACT:R-HSA-399710 Activation of anterior HOX genes in hindbrain development during early embryogenesis REACT:R-HSA-5617472 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins REACT:R-HSA-176814 Activation of ATR in response to replication stress REACT:R-HSA-176187 Activation of BAD and translocation to mitochondria REACT:R-HSA-111447 Activation of BH3-only proteins REACT:R-HSA-114452 Activation of BIM and translocation to mitochondria REACT:R-HSA-111446 Activation of BMF and translocation to mitochondria REACT:R-HSA-139910 Activation of C3 and C5 REACT:R-HSA-174577 Activation of CaMK IV REACT:R-HSA-442745 Activation of Ca-permeable Kainate Receptor REACT:R-HSA-451308 Activation of caspases through apoptosome-mediated cleavage REACT:R-HSA-111459 Activation of DNA fragmentation factor REACT:R-HSA-211227 Activation of GABAB receptors REACT:R-HSA-991365 Activation of gene expression by SREBF (SREBP) REACT:R-HSA-2426168 Activation of G protein gated Potassium channels REACT:R-HSA-1296041 Activation of HOX genes during differentiation REACT:R-HSA-5619507 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon REACT:R-HSA-936964 Activation of Kainate Receptors upon glutamate binding REACT:R-HSA-451326 Activation of Matrix Metalloproteinases REACT:R-HSA-1592389 Activation of Na-permeable Kainate Receptors REACT:R-HSA-451307 Activation of NF-kappaB in B cells REACT:R-HSA-1169091 Activation of Nicotinic Acetylcholine Receptors REACT:R-HSA-629602 Activation of NIMA Kinases NEK9, NEK6, NEK7 REACT:R-HSA-2980767 Activation of NMDA receptor upon glutamate binding and postsynaptic events REACT:R-HSA-442755 Activation of NOXA and translocation to mitochondria REACT:R-HSA-111448 Activation of PPARGC1A (PGC-1alpha) by phosphorylation REACT:R-HSA-2151209 Activation of PUMA and translocation to mitochondria REACT:R-HSA-139915 Activation of Rac REACT:R-HSA-428540 Activation of RAS in B cells REACT:R-HSA-1169092 Activation of SMO REACT:R-HSA-5635838 Activation of the AP-1 family of transcription factors REACT:R-HSA-450341 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S REACT:R-HSA-72662 Activation of the phototransduction cascade REACT:R-HSA-2485179 Activation of the pre-replicative complex REACT:R-HSA-68962 Activation of the TFAP2 (AP-2) family of transcription factors REACT:R-HSA-8866907 Activation of TRKA receptors REACT:R-HSA-187015 Activation, translocation and oligomerization of BAX REACT:R-HSA-114294 Activin signaling KEGG:hsa_M00681 Acute myeloid leukemia KEGG:hsa05221 Acyl chain remodeling of CL REACT:R-HSA-1482798 Acyl chain remodeling of DAG and TAG REACT:R-HSA-1482883 Acyl chain remodelling of PC REACT:R-HSA-1482788 Acyl chain remodelling of PE REACT:R-HSA-1482839 Acyl chain remodelling of PG REACT:R-HSA-1482925 Acyl chain remodelling of PI REACT:R-HSA-1482922 Acyl chain remodelling of PS REACT:R-HSA-1482801 Acylglycerol degradation KEGG:hsa_M00098 Adaptive Immune System REACT:R-HSA-1280218 Adenine ribonucleotide biosynthesis, IMP => ADP,ATP KEGG:hsa_M00049 Adenosine P1 receptors REACT:R-HSA-417973 Adenylate cyclase activating pathway REACT:R-HSA-170660 Adenylate cyclase inhibitory pathway REACT:R-HSA-170670 Adherens junction KEGG:hsa04520 Adherens junctions interactions REACT:R-HSA-418990 Adipocytokine signaling pathway KEGG:hsa04920 ADP signalling through P2Y purinoceptor 1 REACT:R-HSA-418592 ADP signalling through P2Y purinoceptor 12 REACT:R-HSA-392170 Adrenaline,noradrenaline inhibits insulin secretion REACT:R-HSA-400042 Adrenaline signalling through Alpha-2 adrenergic receptor REACT:R-HSA-392023 Adrenergic signaling in cardiomyocytes KEGG:hsa04261 Adrenoceptors REACT:R-HSA-390696 Advanced glycosylation endproduct receptor signaling REACT:R-HSA-879415 Aflatoxin activation and detoxification REACT:R-HSA-5423646 African trypanosomiasis KEGG:hsa05143 AGE-RAGE signaling pathway in diabetic complications KEGG:hsa04933 Agmatine biosynthesis REACT:R-HSA-351143 AKT-mediated inactivation of FOXO1A REACT:R-HSA-211163 AKT phosphorylates targets in the cytosol REACT:R-HSA-198323 AKT phosphorylates targets in the nucleus REACT:R-HSA-198693 Alanine, aspartate and glutamate metabolism KEGG:hsa00250 Alcoholism KEGG:hsa05034 Aldosterone-regulated sodium reabsorption KEGG:hsa04960 Aldosterone synthesis and secretion KEGG:hsa04925 ALKBH2 mediated reversal of alkylation damage REACT:R-HSA-112122 ALKBH3 mediated reversal of alkylation damage REACT:R-HSA-112126 Allograft rejection KEGG:hsa05330 Alpha-defensins REACT:R-HSA-1462054 alpha-linolenic acid (ALA) metabolism REACT:R-HSA-2046106 alpha-Linolenic acid metabolism KEGG:hsa00592 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism REACT:R-HSA-2046104 Alpha-oxidation of phytanate REACT:R-HSA-389599 Alternative complement activation REACT:R-HSA-173736 Alzheimer's disease KEGG:hsa05010 AMER1 mutants destabilize the destruction complex REACT:R-HSA-4839748 Amine-derived hormones REACT:R-HSA-209776 Amine ligand-binding receptors REACT:R-HSA-375280 Amine Oxidase reactions REACT:R-HSA-140179 Amino Acid conjugation REACT:R-HSA-156587 Amino acid synthesis and interconversion (transamination) REACT:R-HSA-70614 Amino acid transport across the plasma membrane REACT:R-HSA-352230 Aminoacyl-tRNA biosynthesis KEGG:hsa00970 Aminoacyl-tRNA biosynthesis, eukaryotes KEGG:hsa_M00359 Amino sugar and nucleotide sugar metabolism KEGG:hsa00520 Amoebiasis KEGG:hsa05146 Amphetamine addiction KEGG:hsa05031 AMPK inhibits chREBP transcriptional activation activity REACT:R-HSA-163680 AMPK signaling pathway KEGG:hsa04152 Amplification of signal from the kinetochores REACT:R-HSA-141424 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal REACT:R-HSA-141444 Amyloid fiber formation REACT:R-HSA-977225 Amyotrophic lateral sclerosis (ALS) KEGG:hsa05014 Anchoring fibril formation REACT:R-HSA-2214320 Anchoring of the basal body to the plasma membrane REACT:R-HSA-5620912 Androgen biosynthesis REACT:R-HSA-193048 Antagonism of Activin by Follistatin REACT:R-HSA-2473224 Antifolate resistance KEGG:hsa01523 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers REACT:R-HSA-983695 Antigen Presentation: Folding, assembly and peptide loading of class I MHC REACT:R-HSA-983170 Antigen processing and presentation KEGG:hsa04612 Antigen processing-Cross presentation REACT:R-HSA-1236975 Antigen processing: Ubiquitination & Proteasome degradation REACT:R-HSA-983168 Antimicrobial peptides REACT:R-HSA-6803157 Antiviral mechanism by IFN-stimulated genes REACT:R-HSA-1169410 APC/C:Cdc20 mediated degradation of Cyclin B REACT:R-HSA-174048 APC/C:Cdc20 mediated degradation of mitotic proteins REACT:R-HSA-176409 APC/C:Cdc20 mediated degradation of Securin REACT:R-HSA-174154 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 REACT:R-HSA-174178 APC/C complex KEGG:hsa_M00389 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint REACT:R-HSA-179419 APC-Cdc20 mediated degradation of Nek2A REACT:R-HSA-179409 APC/C-mediated degradation of cell cycle proteins REACT:R-HSA-174143 APC truncation mutants are not K63 polyubiquitinated REACT:R-HSA-5467333 APC truncation mutants have impaired AXIN binding REACT:R-HSA-5467337 Apelin signaling pathway KEGG:hsa04371 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway REACT:R-HSA-5649702 APOBEC3G mediated resistance to HIV-1 infection REACT:R-HSA-180689 Apoptosis KEGG:hsa04210 Apoptosis REACT:R-HSA-109581 Apoptosis induced DNA fragmentation REACT:R-HSA-140342 Apoptosis - multiple species KEGG:hsa04215 Apoptotic cleavage of cell adhesion proteins REACT:R-HSA-351906 Apoptotic cleavage of cellular proteins REACT:R-HSA-111465 Apoptotic execution phase REACT:R-HSA-75153 Apoptotic factor-mediated response REACT:R-HSA-111471 Apoptotic machinery KEGG:hsa_M00685 Aquaporin-mediated transport REACT:R-HSA-445717 Arachidonate production from DAG REACT:R-HSA-426048 Arachidonic acid metabolism KEGG:hsa00590 Arachidonic acid metabolism REACT:R-HSA-2142753 Arginine and proline metabolism KEGG:hsa00330 Arginine biosynthesis KEGG:hsa00220 ARL13B-mediated ciliary trafficking of INPP5E REACT:R-HSA-5624958 ARMS-mediated activation REACT:R-HSA-170984 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 REACT:R-HSA-211957 Arrhythmogenic right ventricular cardiomyopathy (ARVC) KEGG:hsa05412 Aryl hydrocarbon receptor signalling REACT:R-HSA-8937144 Ascorbate and aldarate metabolism KEGG:hsa00053 Asparagine N-linked glycosylation REACT:R-HSA-446203 Assembly of collagen fibrils and other multimeric structures REACT:R-HSA-2022090 Assembly Of The HIV Virion REACT:R-HSA-175474 Assembly of the ORC complex at the origin of replication REACT:R-HSA-68616 Assembly of the pre-replicative complex REACT:R-HSA-68867 Assembly of Viral Components at the Budding Site REACT:R-HSA-168316 Association of licensing factors with the pre-replicative complex REACT:R-HSA-69298 Association of TriC/CCT with target proteins during biosynthesis REACT:R-HSA-390471 Asthma KEGG:hsa05310 Astrocytic Glutamate-Glutamine Uptake And Metabolism REACT:R-HSA-210455 Asymmetric localization of PCP proteins REACT:R-HSA-4608870 A tetrasaccharide linker sequence is required for GAG synthesis REACT:R-HSA-1971475 ATF4 activates genes REACT:R-HSA-380994 ATF6 (ATF6-alpha) activates chaperone genes REACT:R-HSA-381183 ATF6 (ATF6-alpha) activates chaperones REACT:R-HSA-381033 ATP sensitive Potassium channels REACT:R-HSA-1296025 Attachment of GPI anchor to uPAR REACT:R-HSA-162791 Attenuation phase REACT:R-HSA-3371568 AUF1 (hnRNP D0) binds and destabilizes mRNA REACT:R-HSA-450408 AURKA Activation by TPX2 REACT:R-HSA-8854518 Autodegradation of Cdh1 by Cdh1:APC/C REACT:R-HSA-174084 Autodegradation of the E3 ubiquitin ligase COP1 REACT:R-HSA-349425 Autoimmune thyroid disease KEGG:hsa05320 Autointegration results in viral DNA circles REACT:R-HSA-177539 Autophagy - animal KEGG:hsa04140 Autophagy - other KEGG:hsa04136 AXIN missense mutants destabilize the destruction complex REACT:R-HSA-5467340 AXIN mutants destabilize the destruction complex, activating WNT signaling REACT:R-HSA-4839735 Axonal growth inhibition (RHOA activation) REACT:R-HSA-193634 Axonal growth stimulation REACT:R-HSA-209563 Axon guidance KEGG:hsa04360 Axon guidance REACT:R-HSA-422475 Bacterial invasion of epithelial cells KEGG:hsa05100 Basal cell carcinoma KEGG:hsa05217 Basal transcription factors KEGG:hsa03022 Base excision repair KEGG:hsa03410 Base Excision Repair REACT:R-HSA-73884 Base-Excision Repair, AP Site Formation REACT:R-HSA-73929 Basigin interactions REACT:R-HSA-210991 BBSome-mediated cargo-targeting to cilium REACT:R-HSA-5620922 B cell receptor signaling pathway KEGG:hsa04662 BER complex KEGG:hsa_M00296 beta-Alanine metabolism KEGG:hsa00410 Beta-catenin independent WNT signaling REACT:R-HSA-3858494 Beta-catenin phosphorylation cascade REACT:R-HSA-196299 Beta defensins REACT:R-HSA-1461957 betaKlotho-mediated ligand binding REACT:R-HSA-1307965 beta-Oxidation KEGG:hsa_M00087 beta-Oxidation, acyl-CoA synthesis KEGG:hsa_M00086 Beta oxidation of butanoyl-CoA to acetyl-CoA REACT:R-HSA-77352 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA REACT:R-HSA-77346 Beta oxidation of hexanoyl-CoA to butanoyl-CoA REACT:R-HSA-77350 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA REACT:R-HSA-77310 Beta oxidation of myristoyl-CoA to lauroyl-CoA REACT:R-HSA-77285 Beta oxidation of octanoyl-CoA to hexanoyl-CoA REACT:R-HSA-77348 Beta oxidation of palmitoyl-CoA to myristoyl-CoA REACT:R-HSA-77305 Beta-oxidation of pristanoyl-CoA REACT:R-HSA-389887 Beta-oxidation of very long chain fatty acids REACT:R-HSA-390247 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members REACT:R-HSA-111453 Bicarbonate transporters REACT:R-HSA-425381 Bile acid and bile salt metabolism REACT:R-HSA-194068 Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate KEGG:hsa_M00104 Bile secretion KEGG:hsa04976 Binding and entry of HIV virion REACT:R-HSA-173107 Binding and Uptake of Ligands by Scavenger Receptors REACT:R-HSA-2173782 Binding of TCF/LEF:CTNNB1 to target gene promoters REACT:R-HSA-4411364 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB REACT:R-HSA-141333 Biological oxidations REACT:R-HSA-211859 Biosynthesis of A2E, implicated in retinal degradation REACT:R-HSA-2466712 Biosynthesis of amino acids KEGG:hsa01230 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein REACT:R-HSA-446193 Biosynthesis of unsaturated fatty acids KEGG:hsa01040 Biotin metabolism KEGG:hsa00780 Biotin transport and metabolism REACT:R-HSA-196780 Bladder cancer KEGG:hsa05219 Bloom's syndrome complex KEGG:hsa_M00414 BMAL1:CLOCK,NPAS2 activates circadian gene expression REACT:R-HSA-1368108 BMP signaling KEGG:hsa_M00679 Branched-chain amino acid catabolism REACT:R-HSA-70895 BRCA1-associated genome surveillance complex (BASC) KEGG:hsa_M00295 Breakdown of the nuclear lamina REACT:R-HSA-352238 Breast cancer KEGG:hsa05224 Budding REACT:R-HSA-168302 Budding and maturation of HIV virion REACT:R-HSA-162588 Butanoate metabolism KEGG:hsa00650 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA REACT:R-HSA-450385 Butyrophilin (BTN) family interactions REACT:R-HSA-8851680 B-WICH complex positively regulates rRNA expression REACT:R-HSA-5250924 C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone KEGG:hsa_M00110 C1-unit interconversion, eukaryotes KEGG:hsa_M00141 C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone KEGG:hsa_M00108 C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone KEGG:hsa_M00109 C5 isoprenoid biosynthesis, mevalonate pathway KEGG:hsa_M00095 C6 deamination of adenosine REACT:R-HSA-75102 Ca2+ activated K+ channels REACT:R-HSA-1296052 Ca2+ pathway REACT:R-HSA-4086398 Ca-dependent events REACT:R-HSA-111996 Caffeine metabolism KEGG:hsa00232 Calcitonin-like ligand receptors REACT:R-HSA-419812 Calcium signaling pathway KEGG:hsa04020 Calmodulin induced events REACT:R-HSA-111933 Calnexin/calreticulin cycle REACT:R-HSA-901042 CaMK IV-mediated phosphorylation of CREB REACT:R-HSA-111932 CaM pathway REACT:R-HSA-111997 Cam-PDE 1 activation REACT:R-HSA-111957 cAMP signaling KEGG:hsa_M00695 cAMP signaling pathway KEGG:hsa04024 Cap binding complex KEGG:hsa_M00399 Cap-dependent Translation Initiation REACT:R-HSA-72737 Carbohydrate digestion and absorption KEGG:hsa04973 Carbon metabolism KEGG:hsa01200 Cardiac conduction REACT:R-HSA-5576891 Cardiac muscle contraction KEGG:hsa04260 Cargo concentration in the ER REACT:R-HSA-5694530 Cargo recognition for clathrin-mediated endocytosis REACT:R-HSA-8856825 Cargo trafficking to the periciliary membrane REACT:R-HSA-5620920 Carnitine synthesis REACT:R-HSA-71262 CASP8 activity is inhibited REACT:R-HSA-5218900 Caspase activation via extrinsic apoptotic signalling pathway REACT:R-HSA-5357769 Caspase-mediated cleavage of cytoskeletal proteins REACT:R-HSA-264870 Catabolism of glucuronate to xylulose-5-phosphate REACT:R-HSA-5661270 Catecholamine biosynthesis REACT:R-HSA-209905 Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline KEGG:hsa_M00042 Cation-coupled Chloride cotransporters REACT:R-HSA-426117 CD209 (DC-SIGN) signaling REACT:R-HSA-5621575 CD22 mediated BCR regulation REACT:R-HSA-5690714 CD28 co-stimulation REACT:R-HSA-389356 CD28 dependent PI3K/Akt signaling REACT:R-HSA-389357 CD28 dependent Vav1 pathway REACT:R-HSA-389359 Cdc20:Phospho-APC/C mediated degradation of Cyclin A REACT:R-HSA-174184 CDC6 association with the ORC:origin complex REACT:R-HSA-68689 CDK-mediated phosphorylation and removal of Cdc6 REACT:R-HSA-69017 CDO in myogenesis REACT:R-HSA-375170 CDT1 association with the CDC6:ORC:origin complex REACT:R-HSA-68827 Cell adhesion molecules (CAMs) KEGG:hsa04514 Cell-Cell communication REACT:R-HSA-1500931 Cell-cell junction organization REACT:R-HSA-421270 Cell cycle KEGG:hsa04110 Cell Cycle REACT:R-HSA-1640170 Cell Cycle Checkpoints REACT:R-HSA-69620 Cell cycle - G1/S transition KEGG:hsa_M00692 Cell cycle - G2/M transition KEGG:hsa_M00693 Cell Cycle, Mitotic REACT:R-HSA-69278 Cell death signalling via NRAGE, NRIF and NADE REACT:R-HSA-204998 Cell-extracellular matrix interactions REACT:R-HSA-446353 Cell junction organization REACT:R-HSA-446728 Cell redox homeostasis REACT:R-HSA-1222541 Cell surface interactions at the vascular wall REACT:R-HSA-202733 Cellular responses to stress REACT:R-HSA-2262752 Cellular response to heat stress REACT:R-HSA-3371556 Cellular response to hypoxia REACT:R-HSA-2262749 Cellular Senescence REACT:R-HSA-2559583 Central carbon metabolism in cancer KEGG:hsa05230 Centrosome maturation REACT:R-HSA-380287 Ceramide biosynthesis KEGG:hsa_M00094 Ceramide signalling REACT:R-HSA-193681 cGMP effects REACT:R-HSA-418457 cGMP-PKG signaling pathway KEGG:hsa04022 cGMP signaling KEGG:hsa_M00694 Chagas disease (American trypanosomiasis) KEGG:hsa05142 Chaperonin-mediated protein folding REACT:R-HSA-390466 Chemical carcinogenesis KEGG:hsa05204 Chemokine receptors bind chemokines REACT:R-HSA-380108 Chemokine signaling pathway KEGG:hsa04062 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex REACT:R-HSA-75035 CHL1 interactions REACT:R-HSA-447041 Cholecalciferol biosynthesis KEGG:hsa_M00103 Cholesterol biosynthesis REACT:R-HSA-191273 Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterol KEGG:hsa_M00101 Cholesterol biosynthesis via desmosterol REACT:R-HSA-6807047 Cholesterol biosynthesis via lathosterol REACT:R-HSA-6807062 Choline catabolism REACT:R-HSA-6798163 Choline metabolism in cancer KEGG:hsa05231 Cholinergic synapse KEGG:hsa04725 Chondroitin sulfate biosynthesis REACT:R-HSA-2022870 Chondroitin sulfate degradation KEGG:hsa_M00077 Chondroitin sulfate/dermatan sulfate metabolism REACT:R-HSA-1793185 ChREBP activates metabolic gene expression REACT:R-HSA-163765 Chromatin modifying enzymes REACT:R-HSA-3247509 Chromatin organization REACT:R-HSA-4839726 Chromosome Maintenance REACT:R-HSA-73886 Chronic myeloid leukemia KEGG:hsa05220 Chylomicron-mediated lipid transport REACT:R-HSA-174800 Cilium Assembly REACT:R-HSA-5617833 Circadian Clock REACT:R-HSA-400253 Circadian entrainment KEGG:hsa04713 Circadian rhythm KEGG:hsa04710 Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate KEGG:hsa_M00010 Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate KEGG:hsa_M00011 Citrate cycle (TCA cycle) KEGG:hsa00020 Citrate cycle (TCA cycle, Krebs cycle) KEGG:hsa_M00009 Citric acid cycle (TCA cycle) REACT:R-HSA-71403 Class A/1 (Rhodopsin-like receptors) REACT:R-HSA-373076 Class B/2 (Secretin family receptors) REACT:R-HSA-373080 Class C/3 (Metabotropic glutamate/pheromone receptors) REACT:R-HSA-420499 Classical antibody-mediated complement activation REACT:R-HSA-173623 Classical Kir channels REACT:R-HSA-1296053 Class II GLUTs REACT:R-HSA-428776 Class I MHC mediated antigen processing & presentation REACT:R-HSA-983169 Clathrin derived vesicle budding REACT:R-HSA-421837 Clathrin-mediated endocytosis REACT:R-HSA-8856828 Clearance of Nuclear Envelope Membranes from Chromatin REACT:R-HSA-2993913 Cleavage of Growing Transcript in the Termination Region REACT:R-HSA-109688 Cleavage of the damaged purine REACT:R-HSA-110331 Cleavage of the damaged pyrimidine REACT:R-HSA-110329 CLEC7A (Dectin-1) induces NFAT activation REACT:R-HSA-5607763 CLEC7A (Dectin-1) signaling REACT:R-HSA-5607764 CLEC7A/inflammasome pathway REACT:R-HSA-5660668 Cobalamin (Cbl, vitamin B12) transport and metabolism REACT:R-HSA-196741 Cocaine addiction KEGG:hsa05030 Coenzyme A biosynthesis REACT:R-HSA-196783 Coenzyme A biosynthesis, pantothenate => CoA KEGG:hsa_M00120 Cohesin Loading onto Chromatin REACT:R-HSA-2470946 Collagen biosynthesis and modifying enzymes REACT:R-HSA-1650814 Collagen chain trimerization REACT:R-HSA-8948216 Collagen degradation REACT:R-HSA-1442490 Collagen formation REACT:R-HSA-1474290 Collecting duct acid secretion KEGG:hsa04966 Colorectal cancer KEGG:hsa05210 Common Pathway of Fibrin Clot Formation REACT:R-HSA-140875 Complement and coagulation cascades KEGG:hsa04610 Complement cascade REACT:R-HSA-166658 Complex I biogenesis REACT:R-HSA-6799198 Condensation of Prometaphase Chromosomes REACT:R-HSA-2514853 Condensation of Prophase Chromosomes REACT:R-HSA-2299718 Conjugated bile acid biosynthesis, cholate => taurocholate/glycocholate KEGG:hsa_M00106 Conjugation of benzoate with glycine REACT:R-HSA-177135 Conjugation of carboxylic acids REACT:R-HSA-159424 Conjugation of phenylacetate with glutamine REACT:R-HSA-177162 Conjugation of salicylate with glycine REACT:R-HSA-177128 Constitutive Signaling by Aberrant PI3K in Cancer REACT:R-HSA-2219530 Constitutive Signaling by AKT1 E17K in Cancer REACT:R-HSA-5674400 Constitutive Signaling by EGFRvIII REACT:R-HSA-5637810 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants REACT:R-HSA-1236382 Constitutive Signaling by NOTCH1 HD Domain Mutants REACT:R-HSA-2691232 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants REACT:R-HSA-2894862 Constitutive Signaling by NOTCH1 PEST Domain Mutants REACT:R-HSA-2644606 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant REACT:R-HSA-2660826 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase REACT:R-HSA-176407 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding REACT:R-HSA-6814122 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding REACT:R-HSA-389958 COPI-dependent Golgi-to-ER retrograde traffic REACT:R-HSA-6811434 COPII (Coat Protein 2) Mediated Vesicle Transport REACT:R-HSA-204005 COPII complex KEGG:hsa_M00404 COPI-independent Golgi-to-ER retrograde traffic REACT:R-HSA-6811436 COPI-mediated anterograde transport REACT:R-HSA-6807878 Costimulation by the CD28 family REACT:R-HSA-388841 COX reactions REACT:R-HSA-140180 Creatine metabolism REACT:R-HSA-71288 Creatine pathway KEGG:hsa_M00047 Creation of C4 and C2 activators REACT:R-HSA-166786 CREB phosphorylation REACT:R-HSA-199920 CREB phosphorylation through the activation of Adenylate Cyclase REACT:R-HSA-442720 CREB phosphorylation through the activation of CaMKII REACT:R-HSA-442729 CREB phosphorylation through the activation of CaMKK REACT:R-HSA-442717 CREB phosphorylation through the activation of Ras REACT:R-HSA-442742 CRMPs in Sema3A signaling REACT:R-HSA-399956 cRNA Synthesis REACT:R-HSA-192869 Crosslinking of collagen fibrils REACT:R-HSA-2243919 Cross-presentation of particulate exogenous antigens (phagosomes) REACT:R-HSA-1236973 Cross-presentation of soluble exogenous antigens (endosomes) REACT:R-HSA-1236978 CS/DS degradation REACT:R-HSA-2024101 c-src mediated regulation of Cx43 function and closure of gap junctions REACT:R-HSA-191647 CTLA4 inhibitory signaling REACT:R-HSA-389513 C-type lectin receptors (CLRs) REACT:R-HSA-5621481 Cul3-SPOP complex KEGG:hsa_M00384 Cul4-DDB1-CSA complex KEGG:hsa_M00386 Cul4-DDB1-DDB2 complex KEGG:hsa_M00385 Cyclin A/B1 associated events during G2/M transition REACT:R-HSA-69273 Cyclin A:Cdk2-associated events at S phase entry REACT:R-HSA-69656 Cyclin B2 mediated events REACT:R-HSA-157881 Cyclin D associated events in G1 REACT:R-HSA-69231 Cyclin E associated events during G1/S transition REACT:R-HSA-69202 CYP2E1 reactions REACT:R-HSA-211999 Cysteine and methionine metabolism KEGG:hsa00270 Cysteine biosynthesis, homocysteine + serine => cysteine KEGG:hsa_M00338 Cysteine formation from homocysteine REACT:R-HSA-1614603 Cytochrome bc1 complex KEGG:hsa_M00152 Cytochrome bc1 complex respiratory unit KEGG:hsa_M00151 Cytochrome c-mediated apoptotic response REACT:R-HSA-111461 Cytochrome c oxidase KEGG:hsa_M00154 Cytochrome P450 - arranged by substrate type REACT:R-HSA-211897 Cytokine-cytokine receptor interaction KEGG:hsa04060 Cytokine Signaling in Immune system REACT:R-HSA-1280215 Cytosolic DNA-sensing pathway KEGG:hsa04623 Cytosolic iron-sulfur cluster assembly REACT:R-HSA-2564830 Cytosolic sensors of pathogen-associated DNA REACT:R-HSA-1834949 Cytosolic sulfonation of small molecules REACT:R-HSA-156584 Cytosolic tRNA aminoacylation REACT:R-HSA-379716 DAG and IP3 signaling REACT:R-HSA-1489509 DAP12 interactions REACT:R-HSA-2172127 DAP12 signaling REACT:R-HSA-2424491 D-Arginine and D-ornithine metabolism KEGG:hsa00472 DARPP-32 events REACT:R-HSA-180024 DCC mediated attractive signaling REACT:R-HSA-418885 Deactivation of the beta-catenin transactivating complex REACT:R-HSA-3769402 Deadenylation-dependent mRNA decay REACT:R-HSA-429914 Deadenylation of mRNA REACT:R-HSA-429947 Death Receptor Signalling REACT:R-HSA-73887 Decapping complex KEGG:hsa_M00395 Dectin-1 mediated noncanonical NF-kB signaling REACT:R-HSA-5607761 Dectin-2 family REACT:R-HSA-5621480 Defective ABCA12 causes autosomal recessive congenital ichthyosis type 4B REACT:R-HSA-5682294 Defective ABCA1 causes Tangier disease REACT:R-HSA-5682113 Defective ABCA3 causes pulmonary surfactant metabolism dysfunction 3 (SMDP3) REACT:R-HSA-5688399 Defective ABCA3 causes pulmonary surfactant metabolism dysfunction type 3 (SMDP3) REACT:R-HSA-5683678 Defective ABCB11 causes progressive familial intrahepatic cholestasis 2 and benign recurrent intrahepatic cholestasis 2 REACT:R-HSA-5678520 Defective ABCB4 causes progressive familial intrahepatic cholestasis 3, intrahepatic cholestasis of pregnancy 3 and gallbladder disease 1 REACT:R-HSA-5678771 Defective ABCB6 causes isolated colobomatous microphthalmia 7 (MCOPCB7) REACT:R-HSA-5683371 Defective ABCC2 causes Dubin-Johnson syndrome REACT:R-HSA-5679001 Defective ABCC6 causes pseudoxanthoma elasticum (PXE) REACT:R-HSA-5690338 Defective ABCC8 can cause hypoglycemias and hyperglycemias REACT:R-HSA-5683177 Defective ABCC9 causes dilated cardiomyopathy 10, familial atrial fibrillation 12 and hypertrichotic osteochondrodysplasia REACT:R-HSA-5678420 Defective ABCD1 causes adrenoleukodystrophy (ALD) REACT:R-HSA-5684045 Defective ABCD4 causes methylmalonic aciduria and homocystinuria, cblj type (MAHCJ) REACT:R-HSA-5683329 Defective ABCG5 causes sitosterolemia REACT:R-HSA-5679096 Defective ABCG8 causes gallbladder disease 4 and sitosterolemia REACT:R-HSA-5679090 Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) REACT:R-HSA-5579031 Defective ACY1 causes encephalopathy REACT:R-HSA-5579007 Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) REACT:R-HSA-5578997 Defective ALG11 causes ALG11-CDG (CDG-1p) REACT:R-HSA-4551295 Defective ALG12 causes ALG12-CDG (CDG-1g) REACT:R-HSA-4720489 Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) REACT:R-HSA-5633231 Defective ALG1 causes ALG1-CDG (CDG-1k) REACT:R-HSA-4549380 Defective ALG2 causes ALG2-CDG (CDG-1i) REACT:R-HSA-4549349 Defective ALG3 causes ALG3-CDG (CDG-1d) REACT:R-HSA-4720475 Defective ALG6 causes ALG6-CDG (CDG-1c) REACT:R-HSA-4724289 Defective ALG8 causes ALG8-CDG (CDG-1h) REACT:R-HSA-4724325 Defective ALG9 causes ALG9-CDG (CDG-1l) REACT:R-HSA-4720454 Defective AMN causes hereditary megaloblastic anemia 1 REACT:R-HSA-3359462 Defective AVP causes neurohypophyseal diabetes insipidus (NDI) REACT:R-HSA-5619099 Defective B3GALT6 causes EDSP2 and SEMDJL1 REACT:R-HSA-4420332 Defective B3GALTL causes Peters-plus syndrome (PpS) REACT:R-HSA-5083635 Defective B3GAT3 causes JDSSDHD REACT:R-HSA-3560801 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) REACT:R-HSA-3656244 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) REACT:R-HSA-4793953 Defective B4GALT7 causes EDS, progeroid type REACT:R-HSA-3560783 Defective BTD causes biotidinase deficiency REACT:R-HSA-3371598 Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) REACT:R-HSA-5083632 Defective CD320 causes methylmalonic aciduria REACT:R-HSA-3359485 Defective CFTR causes cystic fibrosis REACT:R-HSA-5678895 Defective CHST14 causes EDS, musculocontractural type REACT:R-HSA-3595174 Defective CHST3 causes SEDCJD REACT:R-HSA-3595172 Defective CHST6 causes MCDC1 REACT:R-HSA-3656225 Defective CHSY1 causes TPBS REACT:R-HSA-3595177 Defective CP causes aceruloplasminemia (ACERULOP) REACT:R-HSA-5619060 Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4) REACT:R-HSA-5688890 Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5) REACT:R-HSA-5688849 Defective CUBN causes hereditary megaloblastic anemia 1 REACT:R-HSA-3359463 Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) REACT:R-HSA-5579026 Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) REACT:R-HSA-5579017 Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) REACT:R-HSA-5579009 Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) REACT:R-HSA-5579028 Defective CYP19A1 causes Aromatase excess syndrome (AEXS) REACT:R-HSA-5579030 Defective CYP1B1 causes Glaucoma REACT:R-HSA-5579000 Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3) REACT:R-HSA-5579021 Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) REACT:R-HSA-5579010 Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) REACT:R-HSA-5579015 Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) REACT:R-HSA-5579004 Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) REACT:R-HSA-5578996 Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) REACT:R-HSA-5579014 Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) REACT:R-HSA-5579027 Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) REACT:R-HSA-5579011 Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) REACT:R-HSA-5579005 Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) REACT:R-HSA-5579013 Defective DHDDS causes retinitis pigmentosa 59 REACT:R-HSA-4755609 Defective DOLK causes DOLK-CDG (CDG-1m) REACT:R-HSA-4755583 Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 REACT:R-HSA-4549356 Defective DPM1 causes DPM1-CDG (CDG-1e) REACT:R-HSA-4717374 Defective DPM2 causes DPM2-CDG (CDG-1u) REACT:R-HSA-4719377 Defective DPM3 causes DPM3-CDG (CDG-1o) REACT:R-HSA-4719360 Defective EXT1 causes exostoses 1, TRPS2 and CHDS REACT:R-HSA-3656253 Defective EXT2 causes exostoses 2 REACT:R-HSA-3656237 Defective FMO3 causes Trimethylaminuria (TMAU) REACT:R-HSA-5579019 Defective GALE can cause Epimerase-deficiency galactosemia (EDG) REACT:R-HSA-5609977 Defective GALK1 can cause Galactosemia II (GALCT2) REACT:R-HSA-5609976 Defective GALNT12 causes colorectal cancer 1 (CRCS1) REACT:R-HSA-5083636 Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) REACT:R-HSA-5083625 Defective GALT can cause Galactosemia REACT:R-HSA-5609978 Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) REACT:R-HSA-5619073 Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) REACT:R-HSA-5578999 Defective GFPT1 causes CMSTA1 REACT:R-HSA-4085023 Defective GGT1 causes Glutathionuria (GLUTH) REACT:R-HSA-5579022 Defective GIF causes intrinsic factor deficiency REACT:R-HSA-3359457 Defective GNE causes sialuria, Nonaka myopathy and inclusion body myopathy 2 REACT:R-HSA-4085011 Defective GSS causes Glutathione synthetase deficiency (GSS deficiency) REACT:R-HSA-5579006 Defective HK1 causes hexokinase deficiency (HK deficiency) REACT:R-HSA-5619056 Defective HLCS causes multiple carboxylase deficiency REACT:R-HSA-3371599 Defective LARGE causes MDDGA6 and MDDGB6 REACT:R-HSA-5083627 Defective LFNG causes SCDO3 REACT:R-HSA-5083630 Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF REACT:R-HSA-3359458 Defective MAN1B1 causes MRT15 REACT:R-HSA-4793950 Defective MAOA causes Brunner syndrome (BRUNS) REACT:R-HSA-5579012 Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) REACT:R-HSA-5579024 Defective MGAT2 causes MGAT2-CDG (CDG-2a) REACT:R-HSA-4793952 Defective MMAA causes methylmalonic aciduria type cblA REACT:R-HSA-3359475 Defective MMAB causes methylmalonic aciduria type cblB REACT:R-HSA-3359471 Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC REACT:R-HSA-3359474 Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD REACT:R-HSA-3359473 Defective MOGS causes MOGS-CDG (CDG-2b) REACT:R-HSA-4793954 Defective MPDU1 causes MPDU1-CDG (CDG-1f) REACT:R-HSA-4687000 Defective MPI causes MPI-CDG (CDG-1b) REACT:R-HSA-4043916 Defective MTR causes methylmalonic aciduria and homocystinuria type cblG REACT:R-HSA-3359469 Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE REACT:R-HSA-3359467 Defective MUT causes methylmalonic aciduria mut type REACT:R-HSA-3359478 Defective NEU1 causes sialidosis REACT:R-HSA-4341670 Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) REACT:R-HSA-5578998 Defective PAPSS2 causes SEMD-PA REACT:R-HSA-3560796 Defective PGM1 causes PGM1-CDG (CDG1t) REACT:R-HSA-5609974 Defective PMM2 causes PMM2-CDG (CDG-1a) REACT:R-HSA-4043911 Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 REACT:R-HSA-5083628 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 REACT:R-HSA-5083633 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 REACT:R-HSA-5083629 Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS) REACT:R-HSA-5688031 Defective pro-SFTPC causes pulmonary surfactant metabolism dysfunction 2 (SMDP2) and respiratory distress syndrome (RDS) REACT:R-HSA-5688354 Defective RFT1 causes RFT1-CDG (CDG-1n) REACT:R-HSA-4570571 Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN) REACT:R-HSA-5619042 Defective SFTPA2 causes idiopathic pulmonary fibrosis (IPF) REACT:R-HSA-5687868 Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) REACT:R-HSA-5619048 Defective SLC12A1 causes Bartter syndrome 1 (BS1) REACT:R-HSA-5619104 Defective SLC12A3 causes Gitelman syndrome (GS) REACT:R-HSA-5619087 Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) REACT:R-HSA-5619039 Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) REACT:R-HSA-5619070 Defective SLC17A5 causes Salla disease (SD) and ISSD REACT:R-HSA-5619035 Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25) REACT:R-HSA-5619076 Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) REACT:R-HSA-5619067 Defective SLC1A3 causes episodic ataxia 6 (EA6) REACT:R-HSA-5619062 Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) REACT:R-HSA-5619111 Defective SLC22A12 causes renal hypouricemia 1 (RHUC1) REACT:R-HSA-5619071 Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1) REACT:R-HSA-5619066 Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP) REACT:R-HSA-5619053 Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D) REACT:R-HSA-5619077 Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI) REACT:R-HSA-5619055 Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6) REACT:R-HSA-5619036 Defective SLC26A2 causes chondrodysplasias REACT:R-HSA-3560792 Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1) REACT:R-HSA-5619085 Defective SLC26A4 causes Pendred syndrome (PDS) REACT:R-HSA-5619046 Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) REACT:R-HSA-5619108 Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS) REACT:R-HSA-5619063 Defective SLC2A10 causes arterial tortuosity syndrome (ATS) REACT:R-HSA-5619068 Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) REACT:R-HSA-5619043 Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) REACT:R-HSA-5619098 Defective SLC2A9 causes hypouricemia renal 2 (RHUC2) REACT:R-HSA-5619047 Defective SLC33A1 causes spastic paraplegia 42 (SPG42) REACT:R-HSA-5619061 Defective SLC34A1 causes hypophosphatemic nephrolithiasis/osteoporosis 1 (NPHLOP1) REACT:R-HSA-5619040 Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) REACT:R-HSA-5619045 Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) REACT:R-HSA-5687583 Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) REACT:R-HSA-5619097 Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) REACT:R-HSA-5619037 Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) REACT:R-HSA-5663020 Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M) REACT:R-HSA-5619072 Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS) REACT:R-HSA-5619083 Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C) REACT:R-HSA-5619078 Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) REACT:R-HSA-5579020 Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG) REACT:R-HSA-5619041 Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ) REACT:R-HSA-5619088 Defective SLC3A1 causes cystinuria (CSNU) REACT:R-HSA-5619113 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) REACT:R-HSA-5655799 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) REACT:R-HSA-5619049 Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) REACT:R-HSA-5619050 Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) REACT:R-HSA-5619054 Defective SLC5A1 causes congenital glucose/galactose malabsorption (GGM) REACT:R-HSA-5656364 Defective SLC5A2 causes renal glucosuria (GLYS1) REACT:R-HSA-5658208 Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1) REACT:R-HSA-5619096 Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) REACT:R-HSA-5619114 Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) REACT:R-HSA-5658471 Defective SLC6A18 may confer susceptibility to iminoglycinuria and/or hyperglycinuria REACT:R-HSA-5619079 Defective SLC6A18 may confer susceptibility to iminoglycinuria and/or hyperglycinuria REACT:R-HSA-5659729 Defective SLC6A19 causes Hartnup disorder (HND) REACT:R-HSA-5619044 Defective SLC6A19 causes Hartnup disorder (HND) REACT:R-HSA-5659735 Defective SLC6A2 causes orthostatic intolerance (OI) REACT:R-HSA-5619109 Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) REACT:R-HSA-5619081 Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) REACT:R-HSA-5660724 Defective SLC6A5 causes hyperekplexia 3 (HKPX3) REACT:R-HSA-5619089 Defective SLC7A7 causes lysinuric protein intolerance (LPI) REACT:R-HSA-5660862 Defective SLC7A9 causes cystinuria (CSNU) REACT:R-HSA-5660883 Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH) REACT:R-HSA-5619092 Defective SLC9A9 causes autism 16 (AUTS16) REACT:R-HSA-5619052 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) REACT:R-HSA-5619110 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) REACT:R-HSA-5661182 Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) REACT:R-HSA-5619058 Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2) REACT:R-HSA-5619095 Defective SRD5A3 causes SRD5A3-CDG (CDG-1q) and KHRZ REACT:R-HSA-4755579 Defective ST3GAL3 causes MCT12 and EIEE15 REACT:R-HSA-3656243 Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) REACT:R-HSA-5579032 Defective TCN2 causes hereditary megaloblastic anemia REACT:R-HSA-3359454 Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) REACT:R-HSA-5578995 Defective TRP may confer susceptibility towards thyroid papillary carcinoma (TPC) REACT:R-HSA-5619107 Defective UGT1A1 causes hyperbilirubinemia REACT:R-HSA-5579002 Defective UGT1A4 causes hyperbilirubinemia REACT:R-HSA-5579016 Defects in biotin (Btn) metabolism REACT:R-HSA-3323169 Defects in cobalamin (B12) metabolism REACT:R-HSA-3296469 Defects in vitamin and cofactor metabolism REACT:R-HSA-3296482 Defensins REACT:R-HSA-1461973 Degradation of AXIN REACT:R-HSA-4641257 Degradation of beta-catenin by the destruction complex REACT:R-HSA-195253 Degradation of cysteine and homocysteine REACT:R-HSA-1614558 Degradation of DVL REACT:R-HSA-4641258 Degradation of GABA REACT:R-HSA-916853 Degradation of GLI1 by the proteasome REACT:R-HSA-5610780 Degradation of GLI2 by the proteasome REACT:R-HSA-5610783 Degradation of the extracellular matrix REACT:R-HSA-1474228 Deletions in the AMER1 gene destabilize the destruction complex REACT:R-HSA-5467343 Deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling REACT:R-HSA-5467345 Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels REACT:R-HSA-112308 Depolymerisation of the Nuclear Lamina REACT:R-HSA-4419969 Deposition of new CENPA-containing nucleosomes at the centromere REACT:R-HSA-606279 Depurination REACT:R-HSA-73927 Depyrimidination REACT:R-HSA-73928 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models REACT:R-HSA-8862803 Dermatan sulfate biosynthesis REACT:R-HSA-2022923 Dermatan sulfate degradation KEGG:hsa_M00076 Detoxification of Reactive Oxygen Species REACT:R-HSA-3299685 Deubiquitination REACT:R-HSA-5688426 Developmental Biology REACT:R-HSA-1266738 DEx/H-box helicases activate type I IFN and inflammatory cytokines production REACT:R-HSA-3134963 D-Glutamine and D-glutamate metabolism KEGG:hsa00471 Digestion of dietary carbohydrate REACT:R-HSA-189085 Digestion of dietary lipid REACT:R-HSA-192456 Dilated cardiomyopathy KEGG:hsa05414 Dimerization of procaspase-8 REACT:R-HSA-69416 Disassembly of the destruction complex and recruitment of AXIN to the membrane REACT:R-HSA-4641262 Disease REACT:R-HSA-1643685 Diseases associated with glycosaminoglycan metabolism REACT:R-HSA-3560782 Diseases associated with glycosylation precursor biosynthesis REACT:R-HSA-5609975 Diseases associated with N-glycosylation of proteins REACT:R-HSA-3781860 Diseases associated with O-glycosylation of proteins REACT:R-HSA-3906995 Diseases associated with surfactant metabolism REACT:R-HSA-5687613 Diseases associated with the TLR signaling cascade REACT:R-HSA-5602358 Diseases associated with visual transduction REACT:R-HSA-2474795 Diseases of carbohydrate metabolism REACT:R-HSA-5663084 Diseases of glycosylation REACT:R-HSA-3781865 Diseases of Immune System REACT:R-HSA-5260271 Diseases of metabolism REACT:R-HSA-5668914 Diseases of signal transduction REACT:R-HSA-5663202 Disinhibition of SNARE formation REACT:R-HSA-114516 Disorders of transmembrane transporters REACT:R-HSA-5619115 Displacement of DNA glycosylase by APEX1 REACT:R-HSA-110357 Dissolution of Fibrin Clot REACT:R-HSA-75205 DNA Damage Bypass REACT:R-HSA-73893 DNA damage-induced cell cycle checkpoints KEGG:hsa_M00691 DNA Damage Recognition in GG-NER REACT:R-HSA-5696394 DNA Damage Reversal REACT:R-HSA-73942 DNA Damage/Telomere Stress Induced Senescence REACT:R-HSA-2559586 DNA Double-Strand Break Repair REACT:R-HSA-5693532 DNA Double Strand Break Response REACT:R-HSA-5693606 DNA methylation REACT:R-HSA-5334118 DNA-PK complex KEGG:hsa_M00297 DNA polymerase alpha / primase complex KEGG:hsa_M00261 DNA polymerase delta complex KEGG:hsa_M00262 DNA polymerase epsilon complex KEGG:hsa_M00263 DNA polymerase gamma complex KEGG:hsa_M00294 DNA polymerase zeta complex KEGG:hsa_M00293 DNA Repair REACT:R-HSA-73894 DNA replication KEGG:hsa03030 DNA Replication REACT:R-HSA-69306 DNA replication initiation REACT:R-HSA-68952 DNA Replication Pre-Initiation REACT:R-HSA-69002 DNA strand elongation REACT:R-HSA-69190 Dopamine clearance from the synaptic cleft REACT:R-HSA-379401 Dopamine Neurotransmitter Release Cycle REACT:R-HSA-212676 Dopamine receptors REACT:R-HSA-390651 Dopaminergic synapse KEGG:hsa04728 Dorso-ventral axis formation KEGG:hsa04320 Downregulation of ERBB2:ERBB3 signaling REACT:R-HSA-1358803 Downregulation of ERBB2 signaling REACT:R-HSA-8863795 Downregulation of ERBB4 signaling REACT:R-HSA-1253288 Downregulation of SMAD2/3:SMAD4 transcriptional activity REACT:R-HSA-2173795 Downregulation of TGF-beta receptor signaling REACT:R-HSA-2173788 Downstream signaling events of B Cell Receptor (BCR) REACT:R-HSA-1168372 Downstream signaling of activated FGFR1 REACT:R-HSA-5654687 Downstream signaling of activated FGFR2 REACT:R-HSA-5654696 Downstream signaling of activated FGFR3 REACT:R-HSA-5654708 Downstream signaling of activated FGFR4 REACT:R-HSA-5654716 Downstream signal transduction REACT:R-HSA-186763 Downstream TCR signaling REACT:R-HSA-202424 Drug metabolism - cytochrome P450 KEGG:hsa00982 Drug metabolism - other enzymes KEGG:hsa00983 DSCAM interactions REACT:R-HSA-376172 Dual Incision in GG-NER REACT:R-HSA-5696400 Dual incision in TC-NER REACT:R-HSA-6782135 E2F-enabled inhibition of pre-replication complex formation REACT:R-HSA-113507 E2F mediated regulation of DNA replication REACT:R-HSA-113510 E3 ubiquitin ligases ubiquitinate target proteins REACT:R-HSA-8866654 Early Phase of HIV Life Cycle REACT:R-HSA-162594 ECM proteoglycans REACT:R-HSA-3000178 ECM-receptor interaction KEGG:hsa04512 ECS complex KEGG:hsa_M00388 ECV complex KEGG:hsa_M00383 Effects of PIP2 hydrolysis REACT:R-HSA-114508 EGFR downregulation REACT:R-HSA-182971 EGFR interacts with phospholipase C-gamma REACT:R-HSA-212718 EGFR Transactivation by Gastrin REACT:R-HSA-2179392 EGFR tyrosine kinase inhibitor resistance KEGG:hsa01521 Eicosanoid ligand-binding receptors REACT:R-HSA-391903 Eicosanoids REACT:R-HSA-211979 eIF4F complex KEGG:hsa_M00428 Elastic fibre formation REACT:R-HSA-1566948 Electric Transmission Across Gap Junctions REACT:R-HSA-112303 Electron transport from NADPH to Ferredoxin REACT:R-HSA-2395516 Elevation of cytosolic Ca2+ levels REACT:R-HSA-139853 Endocrine and other factor-regulated calcium reabsorption KEGG:hsa04961 Endocrine resistance KEGG:hsa01522 Endocytosis KEGG:hsa04144 Endogenous sterols REACT:R-HSA-211976 Endometrial cancer KEGG:hsa05213 Endosomal Sorting Complex Required For Transport (ESCRT) REACT:R-HSA-917729 Endosomal/Vacuolar pathway REACT:R-HSA-1236977 Energy dependent regulation of mTOR by LKB1-AMPK REACT:R-HSA-380972 eNOS activation REACT:R-HSA-203615 eNOS activation and regulation REACT:R-HSA-203765 Entry of Influenza Virion into Host Cell via Endocytosis REACT:R-HSA-168275 Enzymatic degradation of dopamine by COMT REACT:R-HSA-379397 Enzymatic degradation of Dopamine by monoamine oxidase REACT:R-HSA-379398 EPHA-mediated growth cone collapse REACT:R-HSA-3928663 EPHB-mediated forward signaling REACT:R-HSA-3928662 EPH-ephrin mediated repulsion of cells REACT:R-HSA-3928665 EPH-Ephrin signaling REACT:R-HSA-2682334 Ephrin signaling REACT:R-HSA-3928664 Epigenetic regulation of gene expression REACT:R-HSA-212165 Epithelial cell signaling in Helicobacter pylori infection KEGG:hsa05120 Epstein-Barr virus infection KEGG:hsa05169 ERBB2 Activates PTK6 Signaling REACT:R-HSA-8847993 ERBB2 Regulates Cell Motility REACT:R-HSA-6785631 ErbB signaling pathway KEGG:hsa04012 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression REACT:R-HSA-427389 ERK/MAPK targets REACT:R-HSA-198753 ERKs are inactivated REACT:R-HSA-202670 ER-Phagosome pathway REACT:R-HSA-1236974 ER Quality Control Compartment (ERQC) REACT:R-HSA-901032 ER to Golgi Anterograde Transport REACT:R-HSA-199977 Erythrocytes take up carbon dioxide and release oxygen REACT:R-HSA-1237044 Erythrocytes take up oxygen and release carbon dioxide REACT:R-HSA-1247673 ESCRT-0 complex KEGG:hsa_M00408 ESCRT-I complex KEGG:hsa_M00409 ESCRT-II complex KEGG:hsa_M00410 ESCRT-III complex KEGG:hsa_M00412 Essential fructosuria REACT:R-HSA-5657562 Essential pentosuria REACT:R-HSA-5662853 Establishment of Sister Chromatid Cohesion REACT:R-HSA-2468052 Estrogen biosynthesis REACT:R-HSA-193144 Estrogen signaling pathway KEGG:hsa04915 Ethanol oxidation REACT:R-HSA-71384 Ether lipid metabolism KEGG:hsa00565 Eukaryotic Translation Elongation REACT:R-HSA-156842 Eukaryotic Translation Initiation REACT:R-HSA-72613 Eukaryotic Translation Termination REACT:R-HSA-72764 Exon junction complex (EJC) KEGG:hsa_M00430 Exosome, archaea KEGG:hsa_M00390 Exosome, eukaryotes KEGG:hsa_M00391 Export of Viral Ribonucleoproteins from Nucleus REACT:R-HSA-168274 Extension of Telomeres REACT:R-HSA-180786 Extracellular matrix organization REACT:R-HSA-1474244 Extrinsic Pathway of Fibrin Clot Formation REACT:R-HSA-140834 Facilitative Na+-independent glucose transporters REACT:R-HSA-428790 FA core complex KEGG:hsa_M00413 Factors involved in megakaryocyte development and platelet production REACT:R-HSA-983231 Fanconi anemia pathway KEGG:hsa03460 Fanconi Anemia Pathway REACT:R-HSA-6783310 FasL/ CD95L signaling REACT:R-HSA-75157 Fat digestion and absorption KEGG:hsa04975 Fatty acid biosynthesis KEGG:hsa00061 Fatty acid biosynthesis, elongation KEGG:hsa_M00083 Fatty acid biosynthesis, elongation, endoplasmic reticulum KEGG:hsa_M00415 Fatty acid biosynthesis, elongation, mitochondria KEGG:hsa_M00085 Fatty acid biosynthesis, initiation KEGG:hsa_M00082 Fatty acid degradation KEGG:hsa00071 Fatty acid elongation KEGG:hsa00062 Fatty acid metabolism KEGG:hsa01212 Fatty acids REACT:R-HSA-211935 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion REACT:R-HSA-434316 Fatty acid, triacylglycerol, and ketone body metabolism REACT:R-HSA-535734 Fatty Acyl-CoA Biosynthesis REACT:R-HSA-75105 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis REACT:R-HSA-8854050 FBXW7 Mutants and NOTCH1 in Cancer REACT:R-HSA-2644605 Fc epsilon receptor (FCERI) signaling REACT:R-HSA-2454202 Fc epsilon RI signaling pathway KEGG:hsa04664 FCERI mediated Ca+2 mobilization REACT:R-HSA-2871809 FCERI mediated MAPK activation REACT:R-HSA-2871796 FCERI mediated NF-kB activation REACT:R-HSA-2871837 Fcgamma receptor (FCGR) dependent phagocytosis REACT:R-HSA-2029480 Fc gamma R-mediated phagocytosis KEGG:hsa04666 FCGR activation REACT:R-HSA-2029481 Ferroptosis KEGG:hsa04216 Fertilization REACT:R-HSA-1187000 FGFR1b ligand binding and activation REACT:R-HSA-190370 FGFR1c and Klotho ligand binding and activation REACT:R-HSA-190374 FGFR1c ligand binding and activation REACT:R-HSA-190373 FGFR1 ligand binding and activation REACT:R-HSA-190242 FGFR1 mutant receptor activation REACT:R-HSA-1839124 FGFR2 alternative splicing REACT:R-HSA-6803529 FGFR2b ligand binding and activation REACT:R-HSA-190377 FGFR2c ligand binding and activation REACT:R-HSA-190375 FGFR2 ligand binding and activation REACT:R-HSA-190241 FGFR2 mutant receptor activation REACT:R-HSA-1839126 FGFR3b ligand binding and activation REACT:R-HSA-190371 FGFR3c ligand binding and activation REACT:R-HSA-190372 FGFR3 ligand binding and activation REACT:R-HSA-190239 FGFR3 mutant receptor activation REACT:R-HSA-2033514 FGFR4 ligand binding and activation REACT:R-HSA-190322 FGFR4 mutant receptor activation REACT:R-HSA-1839128 FGFRL1 modulation of FGFR1 signaling REACT:R-HSA-5658623 Fibronectin matrix formation REACT:R-HSA-1566977 Ficolins bind to repetitive carbohydrate structures on the target cell surface REACT:R-HSA-2855086 Fluid shear stress and atherosclerosis KEGG:hsa05418 FMO oxidises nucleophiles REACT:R-HSA-217271 Focal adhesion KEGG:hsa04510 Folate biosynthesis KEGG:hsa00790 Folding of actin by CCT/TriC REACT:R-HSA-390450 Formation of annular gap junctions REACT:R-HSA-196025 Formation of a pool of free 40S subunits REACT:R-HSA-72689 Formation of apoptosome REACT:R-HSA-111458 Formation of ATP by chemiosmotic coupling REACT:R-HSA-163210 Formation of editosomes by ADAR proteins REACT:R-HSA-77042 Formation of Fibrin Clot (Clotting Cascade) REACT:R-HSA-140877 Formation of HIV-1 elongation complex containing HIV-1 Tat REACT:R-HSA-167200 Formation of HIV elongation complex in the absence of HIV Tat REACT:R-HSA-167152 Formation of Incision Complex in GG-NER REACT:R-HSA-5696395 Formation of RNA Pol II elongation complex REACT:R-HSA-112382 Formation of selenosugars for excretion REACT:R-HSA-2408499 Formation of Senescence-Associated Heterochromatin Foci (SAHF) REACT:R-HSA-2559584 Formation of TC-NER Pre-Incision Complex REACT:R-HSA-6781823 Formation of the active cofactor, UDP-glucuronate REACT:R-HSA-173599 Formation of the beta-catenin:TCF transactivating complex REACT:R-HSA-201722 Formation of the cornified envelope REACT:R-HSA-6809371 Formation of the Early Elongation Complex REACT:R-HSA-113418 Formation of the Editosome REACT:R-HSA-75094 Formation of the HIV-1 Early Elongation Complex REACT:R-HSA-167158 Formation of the ternary complex, and subsequently, the 43S complex REACT:R-HSA-72695 Formation of tubulin folding intermediates by CCT/TriC REACT:R-HSA-389960 Formyl peptide receptors bind formyl peptides and many other ligands REACT:R-HSA-444473 FoxO signaling pathway KEGG:hsa04068 Free fatty acid receptors REACT:R-HSA-444209 Free fatty acids regulate insulin secretion REACT:R-HSA-400451 Frs2-mediated activation REACT:R-HSA-170968 FRS-mediated FGFR1 signaling REACT:R-HSA-5654693 FRS-mediated FGFR2 signaling REACT:R-HSA-5654700 FRS-mediated FGFR3 signaling REACT:R-HSA-5654706 FRS-mediated FGFR4 signaling REACT:R-HSA-5654712 Fructose and mannose metabolism KEGG:hsa00051 Fructose biosynthesis REACT:R-HSA-5652227 Fructose catabolism REACT:R-HSA-70350 Fructose metabolism REACT:R-HSA-5652084 F-type ATPase, eukaryotes KEGG:hsa_M00158 Fusion and Uncoating of the Influenza Virion REACT:R-HSA-168270 Fusion of the Influenza Virion to the Host Cell Endosome REACT:R-HSA-168288 G0 and Early G1 REACT:R-HSA-1538133 G1 Phase REACT:R-HSA-69236 G1/S DNA Damage Checkpoints REACT:R-HSA-69615 G1/S-Specific Transcription REACT:R-HSA-69205 G1/S Transition REACT:R-HSA-69206 G2/M Checkpoints REACT:R-HSA-69481 G2/M DNA damage checkpoint REACT:R-HSA-69473 G2/M DNA replication checkpoint REACT:R-HSA-69478 G2/M Transition REACT:R-HSA-69275 G2 Phase REACT:R-HSA-68911 GAB1 signalosome REACT:R-HSA-180292 GABA A receptor activation REACT:R-HSA-977441 GABA A (rho) receptor activation REACT:R-HSA-977442 GABA biosynthesis, eukaryotes, putrescine => GABA KEGG:hsa_M00135 GABA B receptor activation REACT:R-HSA-977444 GABAergic synapse KEGG:hsa04727 GABA (gamma-Aminobutyrate) shunt KEGG:hsa_M00027 GABA receptor activation REACT:R-HSA-977443 GABA synthesis REACT:R-HSA-888568 GABA synthesis, release, reuptake and degradation REACT:R-HSA-888590 Galactose catabolism REACT:R-HSA-70370 Galactose degradation, Leloir pathway, galactose => alpha-D-glucose-1P KEGG:hsa_M00632 Galactose metabolism KEGG:hsa00052 G alpha (12/13) signalling events REACT:R-HSA-416482 G alpha (i) signalling events REACT:R-HSA-418594 G alpha (q) signalling events REACT:R-HSA-416476 G alpha (s) signalling events REACT:R-HSA-418555 G alpha (z) signalling events REACT:R-HSA-418597 Gamma carboxylation, hypusine formation and arylsulfatase activation REACT:R-HSA-163841 Gamma-carboxylation of protein precursors REACT:R-HSA-159740 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins REACT:R-HSA-159854 Gap-filling DNA repair synthesis and ligation in GG-NER REACT:R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in TC-NER REACT:R-HSA-6782210 Gap junction KEGG:hsa04540 Gap junction assembly REACT:R-HSA-190861 Gap junction degradation REACT:R-HSA-190873 Gap junction trafficking REACT:R-HSA-190828 Gap junction trafficking and regulation REACT:R-HSA-157858 Gastric acid secretion KEGG:hsa04971 Gastrin-CREB signalling pathway via PKC and MAPK REACT:R-HSA-881907 G beta:gamma signalling through PI3Kgamma REACT:R-HSA-392451 G beta:gamma signalling through PLC beta REACT:R-HSA-418217 GDP-fucose biosynthesis REACT:R-HSA-6787639 Gene Expression REACT:R-HSA-74160 Generation of second messenger molecules REACT:R-HSA-202433 Generic Transcription Pathway REACT:R-HSA-212436 Gene Silencing by RNA REACT:R-HSA-211000 GINS complex KEGG:hsa_M00286 GLI3 is processed to GLI3R by the proteasome REACT:R-HSA-5610785 Glioma KEGG:hsa05214 GLI proteins bind promoters of Hh responsive genes to promote transcription REACT:R-HSA-5635851 Global Genome Nucleotide Excision Repair (GG-NER) REACT:R-HSA-5696399 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion REACT:R-HSA-381676 Glucagon signaling in metabolic regulation REACT:R-HSA-163359 Glucagon signaling pathway KEGG:hsa04922 Glucagon-type ligand receptors REACT:R-HSA-420092 Glucocorticoid biosynthesis REACT:R-HSA-194002 Gluconeogenesis REACT:R-HSA-70263 Gluconeogenesis, oxaloacetate => fructose-6P KEGG:hsa_M00003 Glucose metabolism REACT:R-HSA-70326 Glucose transport REACT:R-HSA-70153 Glucuronate pathway (uronate pathway) KEGG:hsa_M00014 Glucuronidation REACT:R-HSA-156588 Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity REACT:R-HSA-399721 Glutamate Neurotransmitter Release Cycle REACT:R-HSA-210500 Glutamatergic synapse KEGG:hsa04724 Glutathione biosynthesis, glutamate => glutathione KEGG:hsa_M00118 Glutathione conjugation REACT:R-HSA-156590 Glutathione metabolism KEGG:hsa00480 Glutathione synthesis and recycling REACT:R-HSA-174403 Glycerolipid metabolism KEGG:hsa00561 Glycerophospholipid biosynthesis REACT:R-HSA-1483206 Glycerophospholipid catabolism REACT:R-HSA-6814848 Glycerophospholipid metabolism KEGG:hsa00564 Glycine degradation REACT:R-HSA-6783984 Glycine, serine and threonine metabolism KEGG:hsa00260 Glycogen breakdown (glycogenolysis) REACT:R-HSA-70221 Glycogen storage diseases REACT:R-HSA-3229121 Glycogen storage disease type 0 (liver GYS2) REACT:R-HSA-3858516 Glycogen storage disease type 0 (muscle GYS1) REACT:R-HSA-3828062 Glycogen storage disease type Ia (G6PC) REACT:R-HSA-3274531 Glycogen storage disease type Ib (SLC37A4) REACT:R-HSA-3229133 Glycogen storage disease type II (GAA) REACT:R-HSA-5357609 Glycogen storage disease type IV (GBE1) REACT:R-HSA-3878781 Glycogen storage disease type XV (GYG1) REACT:R-HSA-3814836 Glycogen synthesis REACT:R-HSA-3322077 Glycolysis REACT:R-HSA-70171 Glycolysis, core module involving three-carbon compounds KEGG:hsa_M00002 Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate KEGG:hsa_M00001 Glycolysis / Gluconeogenesis KEGG:hsa00010 Glycoprotein hormones REACT:R-HSA-209822 Glycosaminoglycan biosynthesis, chondroitin sulfate backbone KEGG:hsa_M00058 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate KEGG:hsa00532 Glycosaminoglycan biosynthesis, heparan sulfate backbone KEGG:hsa_M00059 Glycosaminoglycan biosynthesis - heparan sulfate / heparin KEGG:hsa00534 Glycosaminoglycan biosynthesis - keratan sulfate KEGG:hsa00533 Glycosaminoglycan biosynthesis, linkage tetrasaccharide KEGG:hsa_M00057 Glycosaminoglycan degradation KEGG:hsa00531 Glycosaminoglycan metabolism REACT:R-HSA-1630316 Glycosphingolipid biosynthesis - ganglio series KEGG:hsa00604 Glycosphingolipid biosynthesis, ganglio series, LacCer => GT3 KEGG:hsa_M00069 Glycosphingolipid biosynthesis - globo and isoglobo series KEGG:hsa00603 Glycosphingolipid biosynthesis, globo-series, LacCer => Gb4Cer KEGG:hsa_M00068 Glycosphingolipid biosynthesis - lacto and neolacto series KEGG:hsa00601 Glycosphingolipid biosynthesis, lacto-series, LacCer => Lc4Cer KEGG:hsa_M00070 Glycosphingolipid biosynthesis, neolacto-series, LacCer => nLc4Cer KEGG:hsa_M00071 Glycosphingolipid metabolism REACT:R-HSA-1660662 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis KEGG:hsa00563 Glyoxylate and dicarboxylate metabolism KEGG:hsa00630 Glyoxylate metabolism and glycine degradation REACT:R-HSA-389661 GnRH signaling pathway KEGG:hsa04912 Golgi Associated Vesicle Biogenesis REACT:R-HSA-432722 Golgi Cisternae Pericentriolar Stack Reorganization REACT:R-HSA-162658 Golgi-to-ER retrograde transport REACT:R-HSA-8856688 GP1b-IX-V activation signalling REACT:R-HSA-430116 GPCR downstream signaling REACT:R-HSA-388396 GPCR ligand binding REACT:R-HSA-500792 GPI-anchor biosynthesis, core oligosaccharide KEGG:hsa_M00065 G-protein activation REACT:R-HSA-202040 G-protein beta:gamma signalling REACT:R-HSA-397795 G protein gated Potassium channels REACT:R-HSA-1296059 G-protein mediated events REACT:R-HSA-112040 GPVI-mediated activation cascade REACT:R-HSA-114604 Graft-versus-host disease KEGG:hsa05332 GRB2 events in EGFR signaling REACT:R-HSA-179812 GRB2 events in ERBB2 signaling REACT:R-HSA-1963640 GRB2:SOS provides linkage to MAPK signaling for Integrins REACT:R-HSA-354194 GRB7 events in ERBB2 signaling REACT:R-HSA-1306955 Growth hormone receptor signaling REACT:R-HSA-982772 GTP hydrolysis and joining of the 60S ribosomal subunit REACT:R-HSA-72706 Guanine ribonucleotide biosynthesis IMP => GDP,GTP KEGG:hsa_M00050 H/ACA ribonucleoprotein complex KEGG:hsa_M00425 HATs acetylate histones REACT:R-HSA-3214847 HCN channels REACT:R-HSA-1296061 HDACs deacetylate histones REACT:R-HSA-3214815 HDL-mediated lipid transport REACT:R-HSA-194223 HDMs demethylate histones REACT:R-HSA-3214842 HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) REACT:R-HSA-5693567 HDR through Homologous Recombination (HRR) REACT:R-HSA-5685942 HDR through MMEJ (alt-NHEJ) REACT:R-HSA-5685939 HDR through Single Strand Annealing (SSA) REACT:R-HSA-5685938 Hedgehog ligand biogenesis REACT:R-HSA-5358346 Hedgehog 'off' state REACT:R-HSA-5610787 Hedgehog 'on' state REACT:R-HSA-5632684 Hedgehog signaling KEGG:hsa_M00678 Hedgehog signaling pathway KEGG:hsa04340 Hematopoietic cell lineage KEGG:hsa04640 Heme biosynthesis REACT:R-HSA-189451 Heme degradation REACT:R-HSA-189483 Hemostasis REACT:R-HSA-109582 Heparan sulfate degradation KEGG:hsa_M00078 Heparan sulfate/heparin (HS-GAG) metabolism REACT:R-HSA-1638091 Hepatitis B KEGG:hsa05161 Hepatitis C KEGG:hsa05160 Hereditary fructose intolerance REACT:R-HSA-5657560 Herpes simplex infection KEGG:hsa05168 Hexose transport REACT:R-HSA-189200 HHAT G278V abrogates palmitoylation of Hh-Np REACT:R-HSA-5658034 Hh mutants abrogate ligand secretion REACT:R-HSA-5387390 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD REACT:R-HSA-5362768 HIF-1 signaling pathway KEGG:hsa04066 Highly calcium permeable nicotinic acetylcholine receptors REACT:R-HSA-629597 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors REACT:R-HSA-629594 Highly sodium permeable acetylcholine nicotinic receptors REACT:R-HSA-629587 Hippo signaling KEGG:hsa_M00683 Hippo signaling pathway KEGG:hsa04390 Hippo signaling pathway -multiple species KEGG:hsa04392 Histamine receptors REACT:R-HSA-390650 Histidine catabolism REACT:R-HSA-70921 Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism REACT:R-HSA-6788656 Histidine metabolism KEGG:hsa00340 HIV elongation arrest and recovery REACT:R-HSA-167287 HIV Infection REACT:R-HSA-162906 HIV Life Cycle REACT:R-HSA-162587 HIV Transcription Elongation REACT:R-HSA-167169 HIV Transcription Initiation REACT:R-HSA-167161 Holo-TFIIH complex KEGG:hsa_M00290 Homologous DNA Pairing and Strand Exchange REACT:R-HSA-5693579 Homologous recombination KEGG:hsa03440 Homology Directed Repair REACT:R-HSA-5693538 Hormone ligand-binding receptors REACT:R-HSA-375281 Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis REACT:R-HSA-163560 Host Interactions of HIV factors REACT:R-HSA-162909 Host Interactions with Influenza Factors REACT:R-HSA-168253 HRD1/SEL1 ERAD complex KEGG:hsa_M00403 HSF1 activation REACT:R-HSA-3371511 HSF1-dependent transactivation REACT:R-HSA-3371571 HS-GAG biosynthesis REACT:R-HSA-2022928 HS-GAG degradation REACT:R-HSA-2024096 HTLV-I infection KEGG:hsa05166 Huntington's disease KEGG:hsa05016 HuR (ELAVL1) binds and stabilizes mRNA REACT:R-HSA-450520 Hyaluronan biosynthesis and export REACT:R-HSA-2142850 Hyaluronan metabolism REACT:R-HSA-2142845 Hyaluronan uptake and degradation REACT:R-HSA-2160916 Hydrolysis of LPC REACT:R-HSA-1483115 Hydrolysis of LPE REACT:R-HSA-1483152 Hydroxycarboxylic acid-binding receptors REACT:R-HSA-3296197 Hypertrophic cardiomyopathy (HCM) KEGG:hsa05410 Hypusine synthesis from eIF5A-lysine REACT:R-HSA-204626 IGF1R signaling cascade REACT:R-HSA-2428924 IkBA variant leads to EDA-ID REACT:R-HSA-5603029 IKBKB deficiency causes SCID REACT:R-HSA-5602636 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) REACT:R-HSA-5603027 IKK complex recruitment mediated by RIP1 REACT:R-HSA-937041 IL-17 signaling pathway KEGG:hsa04657 IL-6-type cytokine receptor ligand interactions REACT:R-HSA-6788467 Immune System REACT:R-HSA-168256 Immunoproteasome KEGG:hsa_M00337 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell REACT:R-HSA-198933 Import of palmitoyl-CoA into the mitochondrial matrix REACT:R-HSA-200425 Inactivation of APC/C via direct inhibition of the APC/C complex REACT:R-HSA-141430 Inactivation of Cdc42 and Rac REACT:R-HSA-428543 Inactivation, recovery and regulation of the phototransduction cascade REACT:R-HSA-2514859 Incretin synthesis, secretion, and inactivation REACT:R-HSA-400508 Infectious disease REACT:R-HSA-5663205 Inflammasomes REACT:R-HSA-622312 Inflammatory bowel disease (IBD) KEGG:hsa05321 Inflammatory mediator regulation of TRP channels KEGG:hsa04750 Influenza A KEGG:hsa05164 Influenza Infection REACT:R-HSA-168254 Influenza Life Cycle REACT:R-HSA-168255 Influenza Viral RNA Transcription and Replication REACT:R-HSA-168273 Influenza Virus Induced Apoptosis REACT:R-HSA-168277 Inhibition of adenylate cyclase pathway REACT:R-HSA-997269 Inhibition of Host mRNA Processing and RNA Silencing REACT:R-HSA-168315 Inhibition of IFN-beta REACT:R-HSA-168888 Inhibition of Interferon Synthesis REACT:R-HSA-168305 Inhibition of PKR REACT:R-HSA-169131 Inhibition of replication initiation of damaged DNA by RB1/E2F1 REACT:R-HSA-113501 Inhibition of Signaling by Overexpressed EGFR REACT:R-HSA-5638303 Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components REACT:R-HSA-141405 Inhibition of TSC complex formation by PKB REACT:R-HSA-165181 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits REACT:R-HSA-997272 Initial triggering of complement REACT:R-HSA-166663 Initiation of Nuclear Envelope Reformation REACT:R-HSA-2995383 InlA-mediated entry of Listeria monocytogenes into host cells REACT:R-HSA-8876493 InlB-mediated entry of Listeria monocytogenes into host cell REACT:R-HSA-8875360 Innate Immune System REACT:R-HSA-168249 Inosine monophosphate biosynthesis, PRPP + glutamine => IMP KEGG:hsa_M00048 Inositol phosphate metabolism KEGG:hsa00562 Inositol phosphate metabolism REACT:R-HSA-1483249 Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositol KEGG:hsa_M00131 Inositol phosphate metabolism, Ins(1,3,4)P3 => phytate KEGG:hsa_M00132 Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 KEGG:hsa_M00130 Inositol transporters REACT:R-HSA-429593 Insulin effects increased synthesis of Xylulose-5-Phosphate REACT:R-HSA-163754 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA REACT:R-HSA-428359 Insulin processing REACT:R-HSA-264876 Insulin receptor recycling REACT:R-HSA-77387 Insulin receptor signalling cascade REACT:R-HSA-74751 Insulin resistance KEGG:hsa04931 Insulin secretion KEGG:hsa04911 Insulin signaling pathway KEGG:hsa04910 Integration of energy metabolism REACT:R-HSA-163685 Integration of provirus REACT:R-HSA-162592 Integration of viral DNA into host genomic DNA REACT:R-HSA-175567 Integrin alphaIIb beta3 signaling REACT:R-HSA-354192 Integrin cell surface interactions REACT:R-HSA-216083 Interaction between L1 and Ankyrins REACT:R-HSA-445095 Interaction between PHLDA1 and AURKA REACT:R-HSA-8854521 Interactions of neurexins and neuroligins at synapses REACT:R-HSA-6794361 Interactions of Rev with host cellular proteins REACT:R-HSA-177243 Interactions of Tat with host cellular proteins REACT:R-HSA-176034 Interactions of Vpr with host cellular proteins REACT:R-HSA-176033 Interaction With Cumulus Cells REACT:R-HSA-2534343 Interaction With The Zona Pellucida REACT:R-HSA-1300644 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate REACT:R-HSA-880009 Interconversion of polyamines REACT:R-HSA-351200 Interferon alpha/beta signaling REACT:R-HSA-909733 Interferon gamma signaling REACT:R-HSA-877300 Interferon Signaling REACT:R-HSA-913531 Interleukin-10 signaling REACT:R-HSA-6783783 Interleukin-12 signaling REACT:R-HSA-447115 Interleukin-17 signaling REACT:R-HSA-448424 Interleukin-19, 20, 22, 24 REACT:R-HSA-8854691 Interleukin-1 processing REACT:R-HSA-448706 Interleukin-1 signaling REACT:R-HSA-446652 Interleukin-2 signaling REACT:R-HSA-451927 Interleukin-3, 5 and GM-CSF signaling REACT:R-HSA-512988 Interleukin-4 and 13 signaling REACT:R-HSA-6785807 Interleukin-6 family signaling REACT:R-HSA-6783589 Interleukin-6 signaling REACT:R-HSA-1059683 Interleukin-7 signaling REACT:R-HSA-1266695 Interleukin receptor SHC signaling REACT:R-HSA-912526 Intestinal immune network for IgA production KEGG:hsa04672 Intestinal infectious diseases REACT:R-HSA-8942233 Intestinal saccharidase deficiencies REACT:R-HSA-5659898 Intraflagellar transport REACT:R-HSA-5620924 Intra-Golgi and retrograde Golgi-to-ER traffic REACT:R-HSA-6811442 Intra-Golgi traffic REACT:R-HSA-6811438 Intrinsic Pathway for Apoptosis REACT:R-HSA-109606 Intrinsic Pathway of Fibrin Clot Formation REACT:R-HSA-140837 Inwardly rectifying K+ channels REACT:R-HSA-1296065 Ion channel transport REACT:R-HSA-983712 Ion homeostasis REACT:R-HSA-5578775 Ion influx/efflux at host-pathogen interface REACT:R-HSA-6803544 Ionotropic activity of Kainate Receptors REACT:R-HSA-451306 Ion transport by P-type ATPases REACT:R-HSA-936837 IP3 and IP4 transport between cytosol and nucleus REACT:R-HSA-1855196 IP6 and IP7 transport between cytosol and nucleus REACT:R-HSA-1855229 IPs transport between cytosol and ER lumen REACT:R-HSA-1855184 IPs transport between ER lumen and cytosol REACT:R-HSA-1855215 IPs transport between ER lumen and nucleus REACT:R-HSA-1855156 IPs transport between nucleus and cytosol REACT:R-HSA-1855170 IPs transport between nucleus and ER lumen REACT:R-HSA-1855192 IRAK1 recruits IKK complex REACT:R-HSA-937039 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation REACT:R-HSA-975144 IRAK2 mediated activation of TAK1 complex REACT:R-HSA-937042 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation REACT:R-HSA-975163 IRAK4 deficiency (TLR2/4) REACT:R-HSA-5603041 IRAK4 deficiency (TLR5) REACT:R-HSA-5603037 IRE1alpha activates chaperones REACT:R-HSA-381070 IRF3 mediated activation of type 1 IFN REACT:R-HSA-1606341 IRF3-mediated induction of type I IFN REACT:R-HSA-3270619 Iron uptake and transport REACT:R-HSA-917937 IRS activation REACT:R-HSA-74713 IRS-mediated signalling REACT:R-HSA-112399 IRS-related events triggered by IGF1R REACT:R-HSA-2428928 ISG15 antiviral mechanism REACT:R-HSA-1169408 JAK-STAT signaling KEGG:hsa_M00684 Jak-STAT signaling pathway KEGG:hsa04630 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 REACT:R-HSA-450321 Josephin domain DUBs REACT:R-HSA-5689877 Keratan sulfate biosynthesis REACT:R-HSA-2022854 Keratan sulfate degradation KEGG:hsa_M00079 Keratan sulfate degradation REACT:R-HSA-2022857 Keratan sulfate/keratin metabolism REACT:R-HSA-1638074 Keratinization REACT:R-HSA-6805567 Ketone body metabolism REACT:R-HSA-74182 Kinesins REACT:R-HSA-983189 KSRP (KHSRP) binds and destabilizes mRNA REACT:R-HSA-450604 L13a-mediated translational silencing of Ceruloplasmin expression REACT:R-HSA-156827 L1CAM interactions REACT:R-HSA-373760 Lactose synthesis REACT:R-HSA-5653890 Lactosylceramide biosynthesis KEGG:hsa_M00066 Lagging Strand Synthesis REACT:R-HSA-69186 Laminin interactions REACT:R-HSA-3000157 Latent infection of Homo sapiens with Mycobacterium tuberculosis REACT:R-HSA-1222352 Late Phase of HIV Life Cycle REACT:R-HSA-162599 LDL-mediated lipid transport REACT:R-HSA-171052 Leading Strand Synthesis REACT:R-HSA-69109 Lectin pathway of complement activation REACT:R-HSA-166662 Legionellosis KEGG:hsa05134 Leishmaniasis KEGG:hsa05140 Leucine degradation, leucine => acetoacetate + acetyl-CoA KEGG:hsa_M00036 Leukocyte transendothelial migration KEGG:hsa04670 Leukotriene receptors REACT:R-HSA-391906 LGI-ADAM interactions REACT:R-HSA-5682910 Ligand-dependent caspase activation REACT:R-HSA-140534 Ligand-gated ion channel transport REACT:R-HSA-975298 Ligand-independent caspase activation via DCC REACT:R-HSA-418889 Ligand-receptor interactions REACT:R-HSA-5632681 Linoleic acid (LA) metabolism REACT:R-HSA-2046105 Linoleic acid metabolism KEGG:hsa00591 Lipid digestion, mobilization, and transport REACT:R-HSA-73923 Lipoic acid metabolism KEGG:hsa00785 Lipoprotein metabolism REACT:R-HSA-174824 Listeria monocytogenes entry into host cells REACT:R-HSA-8876384 Localization of the PINCH-ILK-PARVIN complex to focal adhesions REACT:R-HSA-446343 Longevity regulating pathway KEGG:hsa04211 Longevity regulating pathway - multiple species KEGG:hsa04213 Long-term depression KEGG:hsa04730 Long-term potentiation KEGG:hsa04720 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling REACT:R-HSA-2644607 Loss of Function of SMAD2/3 in Cancer REACT:R-HSA-3304349 Loss of Function of SMAD4 in Cancer REACT:R-HSA-3304347 Loss of Function of TGFBR1 in Cancer REACT:R-HSA-3656534 Loss of Function of TGFBR2 in Cancer REACT:R-HSA-3642278 Loss of Nlp from mitotic centrosomes REACT:R-HSA-380259 Loss of proteins required for interphase microtubule organization from the centrosome REACT:R-HSA-380284 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production REACT:R-HSA-3134973 Lsm 1-7 complex KEGG:hsa_M00397 Lsm 2-8 complex KEGG:hsa_M00396 Lysine biosynthesis KEGG:hsa00300 Lysine catabolism REACT:R-HSA-71064 Lysine degradation KEGG:hsa00310 Lysine degradation, lysine => saccharopine => acetoacetyl-CoA KEGG:hsa_M00032 Lysosomal glycogen catabolism REACT:R-HSA-5357572 Lysosomal oligosaccharide catabolism REACT:R-HSA-8853383 Lysosome KEGG:hsa04142 Lysosome Vesicle Biogenesis REACT:R-HSA-432720 Lysosphingolipid and LPA receptors REACT:R-HSA-419408 Macroautophagy REACT:R-HSA-1632852 Major pathway of rRNA processing in the nucleolus and cytosol REACT:R-HSA-6791226 Malaria KEGG:hsa05144 Malonate semialdehyde pathway, propanoyl-CoA => acetyl-CoA KEGG:hsa_M00013 Mannose type O-glycan biosynthesis KEGG:hsa00515 MAP2K and MAPK activation REACT:R-HSA-5674135 MAP3K8 (TPL2)-dependent MAPK1/3 activation REACT:R-HSA-5684264 MAPK1 (ERK2) activation REACT:R-HSA-112411 MAPK1/MAPK3 signaling REACT:R-HSA-5684996 MAPK3 (ERK1) activation REACT:R-HSA-110056 MAPK6/MAPK4 signaling REACT:R-HSA-5687128 MAPK (ERK1/2) signaling KEGG:hsa_M00687 MAPK (ERK5) signaling KEGG:hsa_M00690 MAPK family signaling cascades REACT:R-HSA-5683057 MAP kinase activation in TLR cascade REACT:R-HSA-450294 MAPK (JNK) signaling KEGG:hsa_M00688 MAPK (p38) signaling KEGG:hsa_M00689 MAPK signaling pathway KEGG:hsa04010 MAPK targets/ Nuclear events mediated by MAP kinases REACT:R-HSA-450282 MASTL Facilitates Mitotic Progression REACT:R-HSA-2465910 Maturity onset diabetes of the young KEGG:hsa04950 MCM complex KEGG:hsa_M00285 Measles KEGG:hsa05162 Meiosis REACT:R-HSA-1500620 Meiotic recombination REACT:R-HSA-912446 Meiotic synapsis REACT:R-HSA-1221632 Melanin biosynthesis REACT:R-HSA-5662702 Melanogenesis KEGG:hsa04916 Melanoma KEGG:hsa05218 Melatonin biosynthesis, tryptophan => serotonin => melatonin KEGG:hsa_M00037 Membrane binding and targetting of GAG proteins REACT:R-HSA-174490 Membrane Trafficking REACT:R-HSA-199991 Metabolic disorders of biological oxidation enzymes REACT:R-HSA-5579029 Metabolic pathways KEGG:hsa01100 Metabolism REACT:R-HSA-1430728 Metabolism of amino acids and derivatives REACT:R-HSA-71291 Metabolism of Angiotensinogen to Angiotensins REACT:R-HSA-2022377 Metabolism of carbohydrates REACT:R-HSA-71387 Metabolism of fat-soluble vitamins REACT:R-HSA-6806667 Metabolism of folate and pterines REACT:R-HSA-196757 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se REACT:R-HSA-2408550 Metabolism of ingested MeSeO2H into MeSeH REACT:R-HSA-5263617 Metabolism of ingested SeMet, Sec, MeSec into H2Se REACT:R-HSA-2408508 Metabolism of lipids and lipoproteins REACT:R-HSA-556833 Metabolism of nitric oxide REACT:R-HSA-202131 Metabolism of non-coding RNA REACT:R-HSA-194441 Metabolism of nucleotides REACT:R-HSA-15869 Metabolism of polyamines REACT:R-HSA-351202 Metabolism of porphyrins REACT:R-HSA-189445 Metabolism of proteins REACT:R-HSA-392499 Metabolism of serotonin REACT:R-HSA-380612 Metabolism of steroid hormones REACT:R-HSA-196071 Metabolism of vitamin K REACT:R-HSA-6806664 Metabolism of vitamins and cofactors REACT:R-HSA-196854 Metabolism of water-soluble vitamins and cofactors REACT:R-HSA-196849 Metabolism of xenobiotics by cytochrome P450 KEGG:hsa00980 MET activates PI3K/AKT signaling REACT:R-HSA-8851907 MET activates PTK2 signaling REACT:R-HSA-8874081 MET activates PTPN11 REACT:R-HSA-8865999 MET activates RAP1 and RAC1 REACT:R-HSA-8875555 MET activates RAS signaling REACT:R-HSA-8851805 MET activates STAT3 REACT:R-HSA-8875791 Metal ion SLC transporters REACT:R-HSA-425410 Metalloprotease DUBs REACT:R-HSA-5689901 Metallothioneins bind metals REACT:R-HSA-5661231 Metal sequestration by antimicrobial proteins REACT:R-HSA-6799990 Methionine degradation KEGG:hsa_M00035 Methionine salvage pathway KEGG:hsa_M00034 Methionine salvage pathway REACT:R-HSA-1237112 Methylation REACT:R-HSA-156581 Methylation of MeSeH for excretion REACT:R-HSA-2408552 MET interacts with TNS proteins REACT:R-HSA-8875513 MET promotes cell motility REACT:R-HSA-8875878 MET Receptor Activation REACT:R-HSA-6806942 MET receptor recycling REACT:R-HSA-8875656 M/G1 Transition REACT:R-HSA-68874 MGMT-mediated DNA damage reversal REACT:R-HSA-5657655 MHC class II antigen presentation REACT:R-HSA-2132295 MicroRNA (miRNA) biogenesis REACT:R-HSA-203927 MicroRNAs in cancer KEGG:hsa05206 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane REACT:R-HSA-190840 Mineral absorption KEGG:hsa04978 Mineralocorticoid biosynthesis REACT:R-HSA-193993 Minus-strand DNA synthesis REACT:R-HSA-164516 Miscellaneous digestion events REACT:R-HSA-8935690 Miscellaneous substrates REACT:R-HSA-211958 Miscellaneous transport and binding events REACT:R-HSA-5223345 Mismatch repair KEGG:hsa03430 Mismatch Repair REACT:R-HSA-5358508 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) REACT:R-HSA-5358606 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) REACT:R-HSA-5358565 Misspliced GSK3beta mutants stabilize beta-catenin REACT:R-HSA-5339716 Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling REACT:R-HSA-5339717 Mitochondrial ABC transporters REACT:R-HSA-1369007 Mitochondrial biogenesis REACT:R-HSA-1592230 Mitochondrial Fatty Acid Beta-Oxidation REACT:R-HSA-77289 mitochondrial fatty acid beta-oxidation of saturated fatty acids REACT:R-HSA-77286 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids REACT:R-HSA-77288 Mitochondrial iron-sulfur cluster biogenesis REACT:R-HSA-1362409 Mitochondrial protein import REACT:R-HSA-1268020 Mitochondrial transcription initiation REACT:R-HSA-163282 Mitochondrial transcription termination REACT:R-HSA-163316 Mitochondrial translation REACT:R-HSA-5368287 Mitochondrial translation elongation REACT:R-HSA-5389840 Mitochondrial translation initiation REACT:R-HSA-5368286 Mitochondrial translation termination REACT:R-HSA-5419276 Mitochondrial tRNA aminoacylation REACT:R-HSA-379726 Mitochondrial Uncoupling Proteins REACT:R-HSA-166187 Mitophagy REACT:R-HSA-5205647 Mitophagy - animal KEGG:hsa04137 Mitotic Anaphase REACT:R-HSA-68882 Mitotic G1-G1/S phases REACT:R-HSA-453279 Mitotic G2-G2/M phases REACT:R-HSA-453274 Mitotic Metaphase/Anaphase Transition REACT:R-HSA-68881 Mitotic Metaphase and Anaphase REACT:R-HSA-2555396 Mitotic Prometaphase REACT:R-HSA-68877 Mitotic Prophase REACT:R-HSA-68875 Mitotic Spindle Checkpoint REACT:R-HSA-69618 Mitotic Telophase/Cytokinesis REACT:R-HSA-68884 Molecules associated with elastic fibres REACT:R-HSA-2129379 Molybdenum cofactor biosynthesis REACT:R-HSA-947581 Morphine addiction KEGG:hsa05032 M Phase REACT:R-HSA-68886 MPS I - Hurler syndrome REACT:R-HSA-2206302 MPS II - Hunter syndrome REACT:R-HSA-2206296 MPS IIIA - Sanfilippo syndrome A REACT:R-HSA-2206307 MPS IIIB - Sanfilippo syndrome B REACT:R-HSA-2206282 MPS IIIC - Sanfilippo syndrome C REACT:R-HSA-2206291 MPS IIID - Sanfilippo syndrome D REACT:R-HSA-2206305 MPS IV - Morquio syndrome A REACT:R-HSA-2206290 MPS IV - Morquio syndrome B REACT:R-HSA-2206308 MPS IX - Natowicz syndrome REACT:R-HSA-2206280 MPS VII - Sly syndrome REACT:R-HSA-2206292 MPS VI - Maroteaux-Lamy syndrome REACT:R-HSA-2206285 mRNA 3'-end processing REACT:R-HSA-72187 mRNA Capping REACT:R-HSA-72086 mRNA decay by 3' to 5' exoribonuclease REACT:R-HSA-429958 mRNA decay by 5' to 3' exoribonuclease REACT:R-HSA-430039 mRNA Editing REACT:R-HSA-75072 mRNA Editing: A to I Conversion REACT:R-HSA-75064 mRNA Editing: C to U Conversion REACT:R-HSA-72200 mRNA Splicing REACT:R-HSA-72172 mRNA Splicing - Major Pathway REACT:R-HSA-72163 mRNA Splicing - Minor Pathway REACT:R-HSA-72165 mRNA surveillance pathway KEGG:hsa03015 MRN complex KEGG:hsa_M00291 Mtb iron assimilation by chelation REACT:R-HSA-1222449 mTORC1-mediated signalling REACT:R-HSA-166208 mTOR signaling pathway KEGG:hsa04150 mTOR signalling REACT:R-HSA-165159 Mucin type O-glycan biosynthesis KEGG:hsa00512 Mucopolysaccharidoses REACT:R-HSA-2206281 Multifunctional anion exchangers REACT:R-HSA-427601 Muscarinic acetylcholine receptors REACT:R-HSA-390648 Muscle contraction REACT:R-HSA-397014 MyD88 cascade initiated on plasma membrane REACT:R-HSA-975871 MyD88 deficiency (TLR2/4) REACT:R-HSA-5602498 MyD88 deficiency (TLR5) REACT:R-HSA-5602680 MyD88 dependent cascade initiated on endosome REACT:R-HSA-975155 MyD88-independent TLR3/TLR4 cascade REACT:R-HSA-166166 MyD88:Mal cascade initiated on plasma membrane REACT:R-HSA-166058 Myoclonic epilepsy of Lafora REACT:R-HSA-3785653 Myogenesis REACT:R-HSA-525793 Na+/Cl- dependent neurotransmitter transporters REACT:R-HSA-442660 NADE modulates death signalling REACT:R-HSA-205025 Na+-dependent glucose transporters REACT:R-HSA-428808 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex KEGG:hsa_M00146 NADH dehydrogenase (ubiquinone) 1 beta subcomplex KEGG:hsa_M00147 NADH dehydrogenase (ubiquinone) Fe-S protein/flavoprotein complex, mitochondria KEGG:hsa_M00143 NADH:ubiquinone oxidoreductase, mitochondria KEGG:hsa_M00142 NADPH regeneration REACT:R-HSA-389542 Natural killer cell mediated cytotoxicity KEGG:hsa04650 NCAM1 interactions REACT:R-HSA-419037 NCAM signaling for neurite out-growth REACT:R-HSA-375165 Nectin/Necl trans heterodimerization REACT:R-HSA-420597 Nef and signal transduction REACT:R-HSA-164944 Nef Mediated CD4 Down-regulation REACT:R-HSA-167590 Nef Mediated CD8 Down-regulation REACT:R-HSA-182218 Nef mediated downregulation of CD28 cell surface expression REACT:R-HSA-164939 Nef mediated downregulation of MHC class I complex cell surface expression REACT:R-HSA-164940 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters REACT:R-HSA-164938 Negative epigenetic regulation of rRNA expression REACT:R-HSA-5250941 Negative feedback regulation of MAPK pathway REACT:R-HSA-5674499 Negative regulation of activity of TFAP2 (AP-2) family transcription factors REACT:R-HSA-8866904 Negative regulation of FGFR1 signaling REACT:R-HSA-5654726 Negative regulation of FGFR2 signaling REACT:R-HSA-5654727 Negative regulation of FGFR3 signaling REACT:R-HSA-5654732 Negative regulation of FGFR4 signaling REACT:R-HSA-5654733 Negative regulation of MAPK pathway REACT:R-HSA-5675221 Negative regulation of MET activity REACT:R-HSA-6807004 Negative regulation of TCF-dependent signaling by DVL-interacting proteins REACT:R-HSA-5368598 Negative regulation of TCF-dependent signaling by WNT ligand antagonists REACT:R-HSA-3772470 Negative regulation of the PI3K/AKT network REACT:R-HSA-199418 Negative regulators of RIG-I/MDA5 signaling REACT:R-HSA-936440 Neomycin, kanamycin and gentamicin biosynthesis KEGG:hsa00524 Nephrin interactions REACT:R-HSA-373753 NEP/NS2 Interacts with the Cellular Export Machinery REACT:R-HSA-168333 Netrin-1 signaling REACT:R-HSA-373752 Netrin mediated repulsion signals REACT:R-HSA-418886 Neuroactive ligand-receptor interaction KEGG:hsa04080 Neurodegenerative Diseases REACT:R-HSA-8863678 Neurofascin interactions REACT:R-HSA-447043 Neuronal System REACT:R-HSA-112316 Neurophilin interactions with VEGF and VEGFR REACT:R-HSA-194306 Neurotoxicity of clostridium toxins REACT:R-HSA-168799 Neurotransmitter Clearance In The Synaptic Cleft REACT:R-HSA-112311 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell REACT:R-HSA-112314 Neurotransmitter Release Cycle REACT:R-HSA-112310 Neurotransmitter uptake and Metabolism In Glial Cells REACT:R-HSA-112313 Neurotrophin signaling pathway KEGG:hsa04722 Neutrophil degranulation REACT:R-HSA-6798695 NFG and proNGF binds to p75NTR REACT:R-HSA-205017 NF-kappa B signaling pathway KEGG:hsa04064 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 REACT:R-HSA-933543 NF-kB is activated and signals survival REACT:R-HSA-209560 NGF-independant TRKA activation REACT:R-HSA-187024 NGF processing REACT:R-HSA-167060 NGF signalling via TRKA from the plasma membrane REACT:R-HSA-187037 N-Glycan antennae elongation REACT:R-HSA-975577 N-glycan antennae elongation in the medial/trans-Golgi REACT:R-HSA-975576 N-Glycan biosynthesis KEGG:hsa00510 N-glycan biosynthesis, complex type KEGG:hsa_M00075 N-glycan precursor biosynthesis KEGG:hsa_M00055 N-glycan precursor trimming KEGG:hsa_M00073 N-glycan trimming and elongation in the cis-Golgi REACT:R-HSA-964739 N-glycan trimming in the ER and Calnexin/Calreticulin cycle REACT:R-HSA-532668 N-glycosylation by oligosaccharyltransferase KEGG:hsa_M00072 Nicotinamide salvaging REACT:R-HSA-197264 Nicotinate and nicotinamide metabolism KEGG:hsa00760 Nicotinate metabolism REACT:R-HSA-196807 Nicotine addiction KEGG:hsa05033 NIK-->noncanonical NF-kB signaling REACT:R-HSA-5676590 Nitric oxide stimulates guanylate cyclase REACT:R-HSA-392154 Nitrogen metabolism KEGG:hsa00910 NOD1/2 Signaling Pathway REACT:R-HSA-168638 NOD-like receptor signaling pathway KEGG:hsa04621 Non-alcoholic fatty liver disease (NAFLD) KEGG:hsa04932 Non-homologous end-joining KEGG:hsa03450 Nonhomologous End-Joining (NHEJ) REACT:R-HSA-5693571 Non-integrin membrane-ECM interactions REACT:R-HSA-3000171 Nonsense-Mediated Decay (NMD) REACT:R-HSA-927802 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) REACT:R-HSA-975957 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) REACT:R-HSA-975956 Non-small cell lung cancer KEGG:hsa05223 NoRC negatively regulates rRNA expression REACT:R-HSA-427413 Norepinephrine Neurotransmitter Release Cycle REACT:R-HSA-181430 NOSIP mediated eNOS trafficking REACT:R-HSA-203754 NOSTRIN mediated eNOS trafficking REACT:R-HSA-203641 NOTCH1 Intracellular Domain Regulates Transcription REACT:R-HSA-2122947 NOTCH2 Activation and Transmission of Signal to the Nucleus REACT:R-HSA-2979096 NOTCH2 intracellular domain regulates transcription REACT:R-HSA-2197563 Notch-HLH transcription pathway REACT:R-HSA-350054 Notch signaling KEGG:hsa_M00682 Notch signaling pathway KEGG:hsa04330 NR1D1 (REV-ERBA) represses gene expression REACT:R-HSA-1368071 NRAGE signals death through JNK REACT:R-HSA-193648 NrCAM interactions REACT:R-HSA-447038 NRIF signals cell death from the nucleus REACT:R-HSA-205043 NS1 Mediated Effects on Host Pathways REACT:R-HSA-168276 Nuclear Envelope Breakdown REACT:R-HSA-2980766 Nuclear Envelope Reassembly REACT:R-HSA-2995410 Nuclear Events (kinase and transcription factor activation) REACT:R-HSA-198725 Nuclear import of Rev protein REACT:R-HSA-180746 Nuclear pore complex KEGG:hsa_M00427 Nuclear Pore Complex (NPC) Disassembly REACT:R-HSA-3301854 Nuclear Receptor transcription pathway REACT:R-HSA-383280 Nuclear signaling by ERBB4 REACT:R-HSA-1251985 Nucleosome assembly REACT:R-HSA-774815 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways REACT:R-HSA-168643 Nucleotide excision repair KEGG:hsa03420 Nucleotide Excision Repair REACT:R-HSA-5696398 Nucleotide-like (purinergic) receptors REACT:R-HSA-418038 Nucleotide sugar biosynthesis, eukaryotes KEGG:hsa_M00361 Nucleotide sugar biosynthesis, galactose => UDP-galactose KEGG:hsa_M00554 Nucleotide sugar biosynthesis, glucose => UDP-glucose KEGG:hsa_M00549 O2/CO2 exchange in erythrocytes REACT:R-HSA-1480926 O-glycan biosynthesis, mucin type core KEGG:hsa_M00056 O-glycosylation of TSR domain-containing proteins REACT:R-HSA-5173214 Olfactory Signaling Pathway REACT:R-HSA-381753 Olfactory transduction KEGG:hsa04740 Oligomerization of connexins into connexons REACT:R-HSA-190704 O-linked glycosylation REACT:R-HSA-5173105 O-linked glycosylation of mucins REACT:R-HSA-913709 Oncogene Induced Senescence REACT:R-HSA-2559585 Oncogenic MAPK signaling REACT:R-HSA-6802957 One carbon pool by folate KEGG:hsa00670 Oocyte meiosis KEGG:hsa04114 Opioid Signalling REACT:R-HSA-111885 Opsins REACT:R-HSA-419771 Orc1 removal from chromatin REACT:R-HSA-68949 Orexin and neuropeptides FF and QRFP bind to their respective receptors REACT:R-HSA-389397 Organelle biogenesis and maintenance REACT:R-HSA-1852241 Organic anion transport REACT:R-HSA-561048 Organic anion transporters REACT:R-HSA-428643 Organic cation/anion/zwitterion transport REACT:R-HSA-549132 Organic cation transport REACT:R-HSA-549127 Origin recognition complex KEGG:hsa_M00284 Osteoclast differentiation KEGG:hsa04380 Other glycan degradation KEGG:hsa00511 Other semaphorin interactions REACT:R-HSA-416700 Other types of O-glycan biosynthesis KEGG:hsa00514 Ovarian steroidogenesis KEGG:hsa04913 Ovarian tumor domain proteases REACT:R-HSA-5689896 Oxidative phosphorylation KEGG:hsa00190 Oxidative Stress Induced Senescence REACT:R-HSA-2559580 Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha REACT:R-HSA-1234162 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha REACT:R-HSA-1234176 Oxytocin signaling pathway KEGG:hsa04921 p130Cas linkage to MAPK signaling for integrins REACT:R-HSA-372708 P2Y receptors REACT:R-HSA-417957 p38MAPK events REACT:R-HSA-171007 p53-Dependent G1 DNA Damage Response REACT:R-HSA-69563 p53-Dependent G1/S DNA damage checkpoint REACT:R-HSA-69580 p53-Independent DNA Damage Response REACT:R-HSA-69610 p53-Independent G1/S DNA damage checkpoint REACT:R-HSA-69613 p53 signaling pathway KEGG:hsa04115 p75NTR negatively regulates cell cycle via SC1 REACT:R-HSA-193670 p75 NTR receptor-mediated signalling REACT:R-HSA-193704 p75NTR recruits signalling complexes REACT:R-HSA-209543 p75NTR regulates axonogenesis REACT:R-HSA-193697 p75NTR signals via NF-kB REACT:R-HSA-193639 p97-Ufd1-Npl4 complex KEGG:hsa_M00400 Packaging of Eight RNA Segments REACT:R-HSA-168303 Packaging Of Telomere Ends REACT:R-HSA-171306 Pancreatic cancer KEGG:hsa05212 Pancreatic secretion KEGG:hsa04972 Pantothenate and CoA biosynthesis KEGG:hsa00770 PAOs oxidise polyamines to amines REACT:R-HSA-141334 Paradoxical activation of RAF signaling by kinase inactive BRAF REACT:R-HSA-6802955 Parkinson's disease KEGG:hsa05012 Passive transport by Aquaporins REACT:R-HSA-432047 Pathogenic Escherichia coli infection KEGG:hsa05130 Pathways in cancer KEGG:hsa05200 Pausing and recovery of HIV elongation REACT:R-HSA-167290 Pausing and recovery of Tat-mediated HIV elongation REACT:R-HSA-167238 PCNA-Dependent Long Patch Base Excision Repair REACT:R-HSA-5651801 PCP/CE pathway REACT:R-HSA-4086400 PD-1 signaling REACT:R-HSA-389948 PDE3B signalling REACT:R-HSA-165160 PECAM1 interactions REACT:R-HSA-210990 Pentose and glucuronate interconversions KEGG:hsa00040 Pentose phosphate pathway KEGG:hsa00030 Pentose phosphate pathway disease REACT:R-HSA-6791465 Pentose phosphate pathway (hexose monophosphate shunt) REACT:R-HSA-71336 Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P KEGG:hsa_M00007 Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P KEGG:hsa_M00006 Pentose phosphate pathway (Pentose phosphate cycle) KEGG:hsa_M00004 Peptide chain elongation REACT:R-HSA-156902 Peptide hormone biosynthesis REACT:R-HSA-209952 Peptide hormone metabolism REACT:R-HSA-2980736 Peptide ligand-binding receptors REACT:R-HSA-375276 PERK regulates gene expression REACT:R-HSA-381042 Peroxisomal lipid metabolism REACT:R-HSA-390918 Peroxisome KEGG:hsa04146 Pertussis KEGG:hsa05133 Phagosome KEGG:hsa04145 Phase 0 - rapid depolarisation REACT:R-HSA-5576892 Phase 1 - Functionalization of compounds REACT:R-HSA-211945 Phase 1 - inactivation of fast Na+ channels REACT:R-HSA-5576894 Phase 2 - plateau phase REACT:R-HSA-5576893 Phase 3 - rapid repolarisation REACT:R-HSA-5576890 Phase 4 - resting membrane potential REACT:R-HSA-5576886 Phase II conjugation REACT:R-HSA-156580 Phenylalanine and tyrosine catabolism REACT:R-HSA-71182 Phenylalanine metabolism KEGG:hsa00360 Phenylalanine, tyrosine and tryptophan biosynthesis KEGG:hsa00400 Phenylketonuria REACT:R-HSA-2160456 Phosphate bond hydrolysis by NTPDase proteins REACT:R-HSA-8850843 Phosphate bond hydrolysis by NUDT proteins REACT:R-HSA-2393930 Phosphatidylcholine (PC) biosynthesis, choline => PC KEGG:hsa_M00090 Phosphatidylcholine (PC) biosynthesis, PE => PC KEGG:hsa_M00091 Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE KEGG:hsa_M00092 Phosphatidylinositol signaling system KEGG:hsa04070 Phospholipase C-mediated cascade: FGFR1 REACT:R-HSA-5654219 Phospholipase C-mediated cascade; FGFR2 REACT:R-HSA-5654221 Phospholipase C-mediated cascade; FGFR3 REACT:R-HSA-5654227 Phospholipase C-mediated cascade; FGFR4 REACT:R-HSA-5654228 Phospholipase D signaling pathway KEGG:hsa04072 Phospholipid metabolism REACT:R-HSA-1483257 Phosphonate and phosphinate metabolism KEGG:hsa00440 phospho-PLA2 pathway REACT:R-HSA-111995 Phosphorylation of CD3 and TCR zeta chains REACT:R-HSA-202427 Phosphorylation of Emi1 REACT:R-HSA-176417 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes REACT:R-HSA-69200 Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes REACT:R-HSA-170145 Phosphorylation of the APC/C REACT:R-HSA-176412 phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex REACT:R-HSA-4839743 Phototransduction KEGG:hsa04744 Physiological factors REACT:R-HSA-5578768 PI3K/AKT activation REACT:R-HSA-198203 PI3K-Akt signaling KEGG:hsa_M00676 PI3K/AKT Signaling in Cancer REACT:R-HSA-2219528 PI3K-Akt signaling pathway KEGG:hsa04151 PI3K Cascade REACT:R-HSA-109704 PI-3K cascade:FGFR1 REACT:R-HSA-5654689 PI-3K cascade:FGFR2 REACT:R-HSA-5654695 PI-3K cascade:FGFR3 REACT:R-HSA-5654710 PI-3K cascade:FGFR4 REACT:R-HSA-5654720 PI3K events in ERBB2 signaling REACT:R-HSA-1963642 PI3K events in ERBB4 signaling REACT:R-HSA-1250342 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling REACT:R-HSA-6811558 PI5P Regulates TP53 Acetylation REACT:R-HSA-6811555 PI and PC transport between ER and Golgi membranes REACT:R-HSA-1483196 PI Metabolism REACT:R-HSA-1483255 Pink/Parkin Mediated Mitophagy REACT:R-HSA-5205685 PIP3 activates AKT signaling REACT:R-HSA-1257604 PIPs transport between early and late endosome membranes REACT:R-HSA-1660502 PIPs transport between early endosome and Golgi membranes REACT:R-HSA-1660537 PIPs transport between Golgi and plasma membranes REACT:R-HSA-1660510 PIPs transport between late endosome and Golgi membranes REACT:R-HSA-1660508 PIPs transport between plasma and early endosome membranes REACT:R-HSA-1660524 PIWI-interacting RNA (piRNA) biogenesis REACT:R-HSA-5601884 PKA activation REACT:R-HSA-163615 PKA activation in glucagon signalling REACT:R-HSA-164378 PKA-mediated phosphorylation of CREB REACT:R-HSA-111931 PKA-mediated phosphorylation of key metabolic factors REACT:R-HSA-163358 PKB-mediated events REACT:R-HSA-109703 PKMTs methylate histone lysines REACT:R-HSA-3214841 Plasmalogen biosynthesis REACT:R-HSA-75896 Platelet activation KEGG:hsa04611 Platelet activation, signaling and aggregation REACT:R-HSA-76002 Platelet Adhesion to exposed collagen REACT:R-HSA-75892 Platelet Aggregation (Plug Formation) REACT:R-HSA-76009 Platelet calcium homeostasis REACT:R-HSA-418360 Platelet degranulation REACT:R-HSA-114608 Platelet homeostasis REACT:R-HSA-418346 Platelet sensitization by LDL REACT:R-HSA-432142 Platinum drug resistance KEGG:hsa01524 PLC beta mediated events REACT:R-HSA-112043 PLCG1 events in ERBB2 signaling REACT:R-HSA-1251932 PLC-gamma1 signalling REACT:R-HSA-167021 Plus-strand DNA synthesis REACT:R-HSA-164525 POLB-Dependent Long Patch Base Excision Repair REACT:R-HSA-110362 Polo-like kinase mediated events REACT:R-HSA-156711 Polyamine biosynthesis, arginine => agmatine => putrescine => spermidine KEGG:hsa_M00133 Polyamine biosynthesis, arginine => ornithine => putrescine KEGG:hsa_M00134 Polymerase switching REACT:R-HSA-69091 Polymerase switching on the C-strand of the telomere REACT:R-HSA-174411 Porphyrin and chlorophyll metabolism KEGG:hsa00860 Positive epigenetic regulation of rRNA expression REACT:R-HSA-5250913 Post-chaperonin tubulin folding pathway REACT:R-HSA-389977 Post NMDA receptor activation events REACT:R-HSA-438064 Postsynaptic nicotinic acetylcholine receptors REACT:R-HSA-622327 Post-transcriptional silencing by small RNAs REACT:R-HSA-426496 Post-translational modification: synthesis of GPI-anchored proteins REACT:R-HSA-163125 Post-translational protein modification REACT:R-HSA-597592 Potassium Channels REACT:R-HSA-1296071 Potassium transport channels REACT:R-HSA-1296067 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation REACT:R-HSA-2892247 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation REACT:R-HSA-2892245 PP2A-mediated dephosphorylation of key metabolic factors REACT:R-HSA-163767 PPARA activates gene expression REACT:R-HSA-1989781 PPAR signaling pathway KEGG:hsa03320 PRC2 methylates histones and DNA REACT:R-HSA-212300 Prefoldin mediated transfer of substrate to CCT/TriC REACT:R-HSA-389957 Pregnenolone biosynthesis REACT:R-HSA-196108 Pre-NOTCH Expression and Processing REACT:R-HSA-1912422 Pre-NOTCH Processing in Golgi REACT:R-HSA-1912420 Pre-NOTCH Processing in the Endoplasmic Reticulum REACT:R-HSA-1912399 Pre-NOTCH Transcription and Translation REACT:R-HSA-1912408 Presynaptic function of Kainate receptors REACT:R-HSA-500657 Presynaptic nicotinic acetylcholine receptors REACT:R-HSA-622323 Presynaptic phase of homologous DNA pairing and strand exchange REACT:R-HSA-5693616 Primary bile acid biosynthesis KEGG:hsa00120 Primary immunodeficiency KEGG:hsa05340 Prion diseases KEGG:hsa05020 Processing and activation of SUMO REACT:R-HSA-3215018 Processing of Capped Intron-Containing Pre-mRNA REACT:R-HSA-72203 Processing of Capped Intronless Pre-mRNA REACT:R-HSA-75067 Processing of DNA double-strand break ends REACT:R-HSA-5693607 Processing of Intronless Pre-mRNAs REACT:R-HSA-77595 Processive synthesis on the C-strand of the telomere REACT:R-HSA-174414 Processive synthesis on the lagging strand REACT:R-HSA-69183 Progesterone-mediated oocyte maturation KEGG:hsa04914 Programmed Cell Death REACT:R-HSA-5357801 Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 REACT:R-HSA-964827 Prolactin receptor signaling REACT:R-HSA-1170546 Prolactin signaling pathway KEGG:hsa04917 Proline biosynthesis, glutamate => proline KEGG:hsa_M00015 Proline catabolism REACT:R-HSA-70688 Prolonged ERK activation events REACT:R-HSA-169893 Propanoate metabolism KEGG:hsa00640 Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA KEGG:hsa_M00741 Propionyl-CoA catabolism REACT:R-HSA-71032 Prostacyclin signalling through prostacyclin receptor REACT:R-HSA-392851 Prostanoid ligand receptors REACT:R-HSA-391908 Prostate cancer KEGG:hsa05215 Proteasome KEGG:hsa03050 Proteasome, 19S regulatory particle (PA700) KEGG:hsa_M00341 Proteasome, 20S core particle KEGG:hsa_M00340 Protein digestion and absorption KEGG:hsa04974 Protein export KEGG:hsa03060 Protein folding REACT:R-HSA-391251 Protein methylation REACT:R-HSA-8876725 Protein processing in endoplasmic reticulum KEGG:hsa04141 Protein-protein interactions at synapses REACT:R-HSA-6794362 Protein repair REACT:R-HSA-5676934 Protein ubiquitination REACT:R-HSA-8852135 Proteoglycans in cancer KEGG:hsa05205 Proton-coupled monocarboxylate transport REACT:R-HSA-433692 Proton-coupled neutral amino acid transporters REACT:R-HSA-428559 Proton/oligopeptide cotransporters REACT:R-HSA-427975 Proximal tubule bicarbonate reclamation KEGG:hsa04964 PRPP biosynthesis, ribose 5P => PRPP KEGG:hsa_M00005 PTEN Loss of Function in Cancer REACT:R-HSA-5674404 PTK6 Activates STAT3 REACT:R-HSA-8849474 PTK6 Down-Regulation REACT:R-HSA-8849472 PTK6 Expression REACT:R-HSA-8849473 PTK6 promotes HIF1A stabilization REACT:R-HSA-8857538 PTK6 Regulates Cell Cycle REACT:R-HSA-8849470 PTK6 Regulates Proteins Involved in RNA Processing REACT:R-HSA-8849468 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases REACT:R-HSA-8849471 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 REACT:R-HSA-8849469 Purine catabolism REACT:R-HSA-74259 Purine metabolism KEGG:hsa00230 Purine metabolism REACT:R-HSA-73847 Purine ribonucleoside monophosphate biosynthesis REACT:R-HSA-73817 Purine salvage REACT:R-HSA-74217 Pyrimidine biosynthesis REACT:R-HSA-500753 Pyrimidine catabolism REACT:R-HSA-73621 Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate KEGG:hsa_M00046 Pyrimidine metabolism KEGG:hsa00240 Pyrimidine metabolism REACT:R-HSA-73848 Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTP KEGG:hsa_M00052 Pyrimidine salvage reactions REACT:R-HSA-73614 Pyrophosphate hydrolysis REACT:R-HSA-71737 Pyruvate metabolism KEGG:hsa00620 Pyruvate metabolism REACT:R-HSA-70268 Pyruvate metabolism and Citric Acid (TCA) cycle REACT:R-HSA-71406 Pyruvate oxidation, pyruvate => acetyl-CoA KEGG:hsa_M00307 RAB GEFs exchange GTP for GDP on RABs REACT:R-HSA-8876198 RAB geranylgeranylation REACT:R-HSA-8873719 RA biosynthesis pathway REACT:R-HSA-5365859 RAF activation REACT:R-HSA-5673000 RAF-independent MAPK1/3 activation REACT:R-HSA-112409 RAF/MAP kinase cascade REACT:R-HSA-5673001 Rap1 signaling pathway KEGG:hsa04015 Rap1 signalling REACT:R-HSA-392517 Ras activation uopn Ca2+ infux through NMDA receptor REACT:R-HSA-442982 RAS signaling downstream of NF1 loss-of-function variants REACT:R-HSA-6802953 Ras signaling pathway KEGG:hsa04014 Reactions specific to the complex N-glycan synthesis pathway REACT:R-HSA-975578 Reactions specific to the hybrid N-glycan synthesis pathway REACT:R-HSA-975574 Recognition and association of DNA glycosylase with site containing an affected purine REACT:R-HSA-110330 Recognition and association of DNA glycosylase with site containing an affected pyrimidine REACT:R-HSA-110328 Recognition of DNA damage by PCNA-containing replication complex REACT:R-HSA-110314 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks REACT:R-HSA-5693565 Recruitment of mitotic centrosome proteins and complexes REACT:R-HSA-380270 Recruitment of NuMA to mitotic centrosomes REACT:R-HSA-380320 Recycling of bile acids and salts REACT:R-HSA-159418 Recycling of eIF2:GDP REACT:R-HSA-72731 Recycling pathway of L1 REACT:R-HSA-437239 Reduction of cytosolic Ca++ levels REACT:R-HSA-418359 Reelin signalling pathway REACT:R-HSA-8866376 Regulated Necrosis REACT:R-HSA-5218859 Regulated proteolysis of p75NTR REACT:R-HSA-193692 Regulation by c-FLIP REACT:R-HSA-3371378 Regulation by TREX1 REACT:R-HSA-3248023 Regulation of actin cytoskeleton KEGG:hsa04810 Regulation of actin dynamics for phagocytic cup formation REACT:R-HSA-2029482 Regulation of activated PAK-2p34 by proteasome mediated degradation REACT:R-HSA-211733 Regulation of APC/C activators between G1/S and early anaphase REACT:R-HSA-176408 Regulation of Apoptosis REACT:R-HSA-169911 Regulation of beta-cell development REACT:R-HSA-186712 Regulation of cholesterol biosynthesis by SREBP (SREBF) REACT:R-HSA-1655829 Regulation of Commissural axon pathfinding by Slit and Robo REACT:R-HSA-428542 Regulation of Complement cascade REACT:R-HSA-977606 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components REACT:R-HSA-446388 Regulation of DNA replication REACT:R-HSA-69304 Regulation of FZD by ubiquitination REACT:R-HSA-4641263 Regulation of gap junction activity REACT:R-HSA-191650 Regulation of gene expression by Hypoxia-inducible Factor REACT:R-HSA-1234158 Regulation of gene expression in beta cells REACT:R-HSA-210745 Regulation of gene expression in early pancreatic precursor cells REACT:R-HSA-210747 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells REACT:R-HSA-210746 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells REACT:R-HSA-210744 Regulation of Glucokinase by Glucokinase Regulatory Protein REACT:R-HSA-170822 Regulation of HSF1-mediated heat shock response REACT:R-HSA-3371453 Regulation of Hypoxia-inducible Factor (HIF) by oxygen REACT:R-HSA-1234174 Regulation of IFNA signaling REACT:R-HSA-912694 Regulation of IFNG signaling REACT:R-HSA-877312 Regulation of innate immune responses to cytosolic DNA REACT:R-HSA-3134975 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) REACT:R-HSA-381426 Regulation of insulin secretion REACT:R-HSA-422356 Regulation of KIT signaling REACT:R-HSA-1433559 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) REACT:R-HSA-400206 Regulation of lipolysis in adipocytes KEGG:hsa04923 Regulation of mitotic cell cycle REACT:R-HSA-453276 Regulation of mRNA stability by proteins that bind AU-rich elements REACT:R-HSA-450531 Regulation of necroptotic cell death REACT:R-HSA-5675482 Regulation of ornithine decarboxylase (ODC) REACT:R-HSA-350562 Regulation of PAK-2p34 activity by PS-GAP/RHG10 REACT:R-HSA-211728 Regulation of PLK1 Activity at G2/M Transition REACT:R-HSA-2565942 Regulation of pyruvate dehydrogenase (PDH) complex REACT:R-HSA-204174 Regulation of RAS by GAPs REACT:R-HSA-5658442 Regulation of signaling by CBL REACT:R-HSA-912631 Regulation of signaling by NODAL REACT:R-HSA-1433617 Regulation of thyroid hormone activity REACT:R-HSA-350864 Regulation of TLR by endogenous ligand REACT:R-HSA-5686938 Regulation of TNFR1 signaling REACT:R-HSA-5357905 Regulation of TP53 Activity REACT:R-HSA-5633007 Regulation of TP53 Activity through Acetylation REACT:R-HSA-6804758 Regulation of TP53 Activity through Association with Co-factors REACT:R-HSA-6804759 Regulation of TP53 Activity through Methylation REACT:R-HSA-6804760 Regulation of TP53 Activity through Phosphorylation REACT:R-HSA-6804756 Regulation of TP53 Degradation REACT:R-HSA-6804757 Regulation of TP53 Expression REACT:R-HSA-6804754 Regulation of TP53 Expression and Degradation REACT:R-HSA-6806003 Relaxin receptors REACT:R-HSA-444821 Release REACT:R-HSA-168298 Release of apoptotic factors from the mitochondria REACT:R-HSA-111457 Release of Hh-Np from the secreting cell REACT:R-HSA-5362798 Removal of aminoterminal propeptides from gamma-carboxylated proteins REACT:R-HSA-159782 Removal of licensing factors from origins REACT:R-HSA-69300 Removal of the Flap Intermediate REACT:R-HSA-69166 Removal of the Flap Intermediate from the C-strand REACT:R-HSA-174437 Renal cell carcinoma KEGG:hsa05211 Renin-angiotensin system KEGG:hsa04614 Renin secretion KEGG:hsa04924 Repression of WNT target genes REACT:R-HSA-4641265 Reproduction REACT:R-HSA-1474165 Resolution of Abasic Sites (AP sites) REACT:R-HSA-73933 Resolution of AP sites via the multiple-nucleotide patch replacement pathway REACT:R-HSA-110373 Resolution of AP sites via the single-nucleotide replacement pathway REACT:R-HSA-110381 Resolution of D-Loop Structures REACT:R-HSA-5693537 Resolution of D-loop Structures through Holliday Junction Intermediates REACT:R-HSA-5693568 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) REACT:R-HSA-5693554 Resolution of Sister Chromatid Cohesion REACT:R-HSA-2500257 Respiratory electron transport REACT:R-HSA-611105 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. REACT:R-HSA-163200 Response of Mtb to phagocytosis REACT:R-HSA-1222499 Response to elevated platelet cytosolic Ca2+ REACT:R-HSA-76005 Response to metal ions REACT:R-HSA-5660526 Retinoid cycle disease events REACT:R-HSA-2453864 Retinoid metabolism and transport REACT:R-HSA-975634 Retinoid metabolism disease events REACT:R-HSA-6809583 Retinol metabolism KEGG:hsa00830 Retrograde endocannabinoid signaling KEGG:hsa04723 Retrograde neurotrophin signalling REACT:R-HSA-177504 Retrograde transport at the Trans-Golgi-Network REACT:R-HSA-6811440 RET signaling REACT:R-HSA-8853659 Reuptake of GABA REACT:R-HSA-888593 Reversal of alkylation damage by DNA dioxygenases REACT:R-HSA-73943 Reverse Transcription of HIV RNA REACT:R-HSA-162589 Reversible hydration of carbon dioxide REACT:R-HSA-1475029 Rev-mediated nuclear export of HIV RNA REACT:R-HSA-165054 RF-C complex KEGG:hsa_M00289 Rhesus glycoproteins mediate ammonium transport. REACT:R-HSA-444411 Rheumatoid arthritis KEGG:hsa05323 Rho GTPase cycle REACT:R-HSA-194840 RHO GTPase Effectors REACT:R-HSA-195258 RHO GTPases activate CIT REACT:R-HSA-5625900 RHO GTPases Activate Formins REACT:R-HSA-5663220 RHO GTPases activate IQGAPs REACT:R-HSA-5626467 RHO GTPases activate KTN1 REACT:R-HSA-5625970 RHO GTPases Activate NADPH Oxidases REACT:R-HSA-5668599 RHO GTPases activate PAKs REACT:R-HSA-5627123 RHO GTPases activate PKNs REACT:R-HSA-5625740 RHO GTPases Activate Rhotekin and Rhophilins REACT:R-HSA-5666185 RHO GTPases Activate ROCKs REACT:R-HSA-5627117 RHO GTPases Activate WASPs and WAVEs REACT:R-HSA-5663213 RHO GTPases regulate CFTR trafficking REACT:R-HSA-5627083 Riboflavin metabolism KEGG:hsa00740 Ribosomal scanning and start codon recognition REACT:R-HSA-72702 Ribosome KEGG:hsa03010 Ribosome biogenesis in eukaryotes KEGG:hsa03008 Ribosome, eukaryotes KEGG:hsa_M00177 RIG-I-like receptor signaling pathway KEGG:hsa04622 RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways REACT:R-HSA-168928 RIPK1-mediated regulated necrosis REACT:R-HSA-5213460 RIP-mediated NFkB activation via ZBP1 REACT:R-HSA-1810476 RMTs methylate histone arginines REACT:R-HSA-3214858 RNA degradation KEGG:hsa03018 RNA Pol II CTD phosphorylation and interaction with CE REACT:R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection REACT:R-HSA-167160 RNA polymerase KEGG:hsa03020 RNA Polymerase I Chain Elongation REACT:R-HSA-73777 RNA polymerase I, eukaryotes KEGG:hsa_M00182 RNA polymerase II, eukaryotes KEGG:hsa_M00180 RNA Polymerase II HIV Promoter Escape REACT:R-HSA-167162 RNA Polymerase III Abortive And Retractive Initiation REACT:R-HSA-749476 RNA Polymerase III Chain Elongation REACT:R-HSA-73780 RNA polymerase III, eukaryotes KEGG:hsa_M00181 RNA Polymerase III Transcription REACT:R-HSA-74158 RNA Polymerase III Transcription Initiation REACT:R-HSA-76046 RNA Polymerase III Transcription Initiation From Type 1 Promoter REACT:R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 2 Promoter REACT:R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 3 Promoter REACT:R-HSA-76071 RNA Polymerase III Transcription Termination REACT:R-HSA-73980 RNA Polymerase II Pre-transcription Events REACT:R-HSA-674695 RNA Polymerase II Promoter Escape REACT:R-HSA-73776 RNA polymerase II transcribes snRNA genes REACT:R-HSA-6807505 RNA Polymerase II Transcription REACT:R-HSA-73857 RNA Polymerase II Transcription Elongation REACT:R-HSA-75955 RNA Polymerase II Transcription Initiation REACT:R-HSA-75953 RNA Polymerase II Transcription Initiation And Promoter Clearance REACT:R-HSA-76042 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening REACT:R-HSA-73779 RNA Polymerase II Transcription Termination REACT:R-HSA-73856 RNA Polymerase I Promoter Clearance REACT:R-HSA-73854 RNA Polymerase I Promoter Escape REACT:R-HSA-73772 RNA Polymerase I Promoter Opening REACT:R-HSA-73728 RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription REACT:R-HSA-504046 RNA Polymerase I Transcription REACT:R-HSA-73864 RNA Polymerase I Transcription Initiation REACT:R-HSA-73762 RNA Polymerase I Transcription Termination REACT:R-HSA-73863 RNA transport KEGG:hsa03013 RNF mutants show enhanced WNT signaling and proliferation REACT:R-HSA-5340588 Role of Abl in Robo-Slit signaling REACT:R-HSA-428890 Role of LAT2/NTAL/LAB on calcium mobilization REACT:R-HSA-2730905 Role of phospholipids in phagocytosis REACT:R-HSA-2029485 Role of second messengers in netrin-1 signaling REACT:R-HSA-418890 RORA activates gene expression REACT:R-HSA-1368082 ROS, RNS production in phagocytes REACT:R-HSA-1222556 RPA complex KEGG:hsa_M00288 RPIA deficiency: failed conversion of R5P to RU5P REACT:R-HSA-5659996 RPIA deficiency: failed conversion of RU5P to R5P REACT:R-HSA-6791461 rRNA modification in the mitochondrion REACT:R-HSA-6793080 rRNA modification in the nucleus and cytosol REACT:R-HSA-6790901 rRNA processing REACT:R-HSA-72312 rRNA processing in the mitochondrion REACT:R-HSA-8868766 rRNA processing in the nucleus and cytosol REACT:R-HSA-8868773 RSK activation REACT:R-HSA-444257 S33 mutants of beta-catenin aren't phosphorylated REACT:R-HSA-5358747 S37 mutants of beta-catenin aren't phosphorylated REACT:R-HSA-5358749 S45 mutants of beta-catenin aren't phosphorylated REACT:R-HSA-5358751 Salivary secretion KEGG:hsa04970 Salmonella infection KEGG:hsa05132 SALM protein interactions at the synapses REACT:R-HSA-8849932 Scavenging by Class A Receptors REACT:R-HSA-3000480 Scavenging by Class B Receptors REACT:R-HSA-3000471 Scavenging by Class F Receptors REACT:R-HSA-3000484 Scavenging by Class H Receptors REACT:R-HSA-3000497 Scavenging of heme from plasma REACT:R-HSA-2168880 SCF-beta-TrCP mediated degradation of Emi1 REACT:R-HSA-174113 SCF-BTRC complex KEGG:hsa_M00380 SCF-FBS complex KEGG:hsa_M00382 SCF-FBW7 complex KEGG:hsa_M00387 SCF-SKP2 complex KEGG:hsa_M00381 SCF(Skp2)-mediated degradation of p27/p21 REACT:R-HSA-187577 Sec61 complex KEGG:hsa_M00401 Selenoamino acid metabolism REACT:R-HSA-2408522 Selenocompound metabolism KEGG:hsa00450 Selenocysteine synthesis REACT:R-HSA-2408557 Sema3A PAK dependent Axon repulsion REACT:R-HSA-399954 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion REACT:R-HSA-399955 Sema4D induced cell migration and growth-cone collapse REACT:R-HSA-416572 Sema4D in semaphorin signaling REACT:R-HSA-400685 Sema4D mediated inhibition of cell attachment and migration REACT:R-HSA-416550 Semaphorin interactions REACT:R-HSA-373755 SeMet incorporation into proteins REACT:R-HSA-2408517 Senescence-Associated Secretory Phenotype (SASP) REACT:R-HSA-2559582 Sensing of DNA Double Strand Breaks REACT:R-HSA-5693548 Separation of Sister Chromatids REACT:R-HSA-2467813 Serine biosynthesis REACT:R-HSA-977347 Serine biosynthesis, glycerate-3P => serine KEGG:hsa_M00020 Serotonergic synapse KEGG:hsa04726 Serotonin and melatonin biosynthesis REACT:R-HSA-209931 Serotonin clearance from the synaptic cleft REACT:R-HSA-380615 Serotonin Neurotransmitter Release Cycle REACT:R-HSA-181429 Serotonin receptors REACT:R-HSA-390666 Severe congenital neutropenia type 4 (G6PC3) REACT:R-HSA-3282872 SHC1 events in EGFR signaling REACT:R-HSA-180336 SHC1 events in ERBB2 signaling REACT:R-HSA-1250196 SHC1 events in ERBB4 signaling REACT:R-HSA-1250347 SHC-mediated cascade:FGFR1 REACT:R-HSA-5654688 SHC-mediated cascade:FGFR2 REACT:R-HSA-5654699 SHC-mediated cascade:FGFR3 REACT:R-HSA-5654704 SHC-mediated cascade:FGFR4 REACT:R-HSA-5654719 SHC-related events triggered by IGF1R REACT:R-HSA-2428933 Shelterin complex KEGG:hsa_M00424 Shigellosis KEGG:hsa05131 Sialic acid metabolism REACT:R-HSA-4085001 Signal amplification REACT:R-HSA-392518 Signal attenuation REACT:R-HSA-74749 Signaling by activated point mutants of FGFR1 REACT:R-HSA-1839122 Signaling by activated point mutants of FGFR3 REACT:R-HSA-1839130 Signaling by Activin REACT:R-HSA-1502540 Signaling by BMP REACT:R-HSA-201451 Signaling by BRAF and RAF fusions REACT:R-HSA-6802952 Signaling by cytosolic FGFR1 fusion mutants REACT:R-HSA-1839117 Signaling by EGFR REACT:R-HSA-177929 Signaling by EGFR in Cancer REACT:R-HSA-1643713 Signaling by EGFRvIII in Cancer REACT:R-HSA-5637812 Signaling by ERBB2 REACT:R-HSA-1227986 Signaling by ERBB4 REACT:R-HSA-1236394 Signaling by FGFR REACT:R-HSA-190236 Signaling by FGFR1 REACT:R-HSA-5654736 Signaling by FGFR1 amplification mutants REACT:R-HSA-1839120 Signaling by FGFR1 in disease REACT:R-HSA-5655302 Signaling by FGFR2 REACT:R-HSA-5654738 Signaling by FGFR2 amplification mutants REACT:R-HSA-2023837 Signaling by FGFR2 fusions REACT:R-HSA-8853333 Signaling by FGFR2 IIIa TM REACT:R-HSA-8851708 Signaling by FGFR2 in disease REACT:R-HSA-5655253 Signaling by FGFR3 REACT:R-HSA-5654741 Signaling by FGFR3 fusions in cancer REACT:R-HSA-8853334 Signaling by FGFR3 in disease REACT:R-HSA-5655332 Signaling by FGFR3 point mutants in cancer REACT:R-HSA-8853338 Signaling by FGFR4 REACT:R-HSA-5654743 Signaling by FGFR4 in disease REACT:R-HSA-5655291 Signaling by FGFR in disease REACT:R-HSA-1226099 Signaling by GPCR REACT:R-HSA-372790 Signaling by Hedgehog REACT:R-HSA-5358351 Signaling by high-kinase activity BRAF mutants REACT:R-HSA-6802948 Signaling by Hippo REACT:R-HSA-2028269 Signaling by Insulin receptor REACT:R-HSA-74752 Signaling by Interleukins REACT:R-HSA-449147 Signaling by Leptin REACT:R-HSA-2586552 Signaling by Ligand-Responsive EGFR Variants in Cancer REACT:R-HSA-5637815 Signaling by MET REACT:R-HSA-6806834 Signaling by moderate kinase activity BRAF mutants REACT:R-HSA-6802946 Signaling by MST1 REACT:R-HSA-8852405 Signaling by NODAL REACT:R-HSA-1181150 Signaling by NOTCH REACT:R-HSA-157118 Signaling by NOTCH1 REACT:R-HSA-1980143 Signaling by NOTCH1 HD Domain Mutants in Cancer REACT:R-HSA-2691230 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer REACT:R-HSA-2894858 Signaling by NOTCH1 in Cancer REACT:R-HSA-2644603 Signaling by NOTCH1 PEST Domain Mutants in Cancer REACT:R-HSA-2644602 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant REACT:R-HSA-2660825 Signaling by NOTCH2 REACT:R-HSA-1980145 Signaling by NOTCH3 REACT:R-HSA-1980148 Signaling by NOTCH4 REACT:R-HSA-1980150 Signaling by Overexpressed Wild-Type EGFR in Cancer REACT:R-HSA-5638302 Signaling by PDGF REACT:R-HSA-186797 Signaling by plasma membrane FGFR1 fusions REACT:R-HSA-8853336 Signaling by PTK6 REACT:R-HSA-8848021 Signaling by RAS mutants REACT:R-HSA-6802949 Signaling by Retinoic Acid REACT:R-HSA-5362517 Signaling by Rho GTPases REACT:R-HSA-194315 Signaling by Robo receptor REACT:R-HSA-376176 Signaling by SCF-KIT REACT:R-HSA-1433557 Signaling by TGF-beta Receptor Complex REACT:R-HSA-170834 Signaling by TGF-beta Receptor Complex in Cancer REACT:R-HSA-3304351 Signaling by the B Cell Receptor (BCR) REACT:R-HSA-983705 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) REACT:R-HSA-2404192 Signaling by VEGF REACT:R-HSA-194138 Signaling by Wnt REACT:R-HSA-195721 Signaling by WNT in cancer REACT:R-HSA-4791275 Signaling pathways regulating pluripotency of stem cells KEGG:hsa04550 Signalling by NGF REACT:R-HSA-166520 Signalling to ERK5 REACT:R-HSA-198765 Signalling to ERKs REACT:R-HSA-187687 Signalling to p38 via RIT and RIN REACT:R-HSA-187706 Signalling to RAS REACT:R-HSA-167044 Signalling to STAT3 REACT:R-HSA-198745 Signal regulatory protein (SIRP) family interactions REACT:R-HSA-391160 Signal Transduction REACT:R-HSA-162582 Signal transduction by L1 REACT:R-HSA-445144 SIRT1 negatively regulates rRNA Expression REACT:R-HSA-427359 Ski complex KEGG:hsa_M00392 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs REACT:R-HSA-77588 SLBP independent Processing of Histone Pre-mRNAs REACT:R-HSA-111367 SLC-mediated transmembrane transport REACT:R-HSA-425407 SLC transporter disorders REACT:R-HSA-5619102 SMAC binds to IAPs REACT:R-HSA-111463 SMAC-mediated apoptotic response REACT:R-HSA-111469 SMAC-mediated dissociation of IAP:caspase complexes REACT:R-HSA-111464 SMAD2/3 MH2 Domain Mutants in Cancer REACT:R-HSA-3315487 SMAD2/3 Phosphorylation Motif Mutants in Cancer REACT:R-HSA-3304356 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription REACT:R-HSA-2173796 SMAD4 MH2 Domain Mutants in Cancer REACT:R-HSA-3311021 Small cell lung cancer KEGG:hsa05222 Small interfering RNA (siRNA) biogenesis REACT:R-HSA-426486 Sm core complex KEGG:hsa_M00398 Smooth Muscle Contraction REACT:R-HSA-445355 SNARE interactions in vesicular transport KEGG:hsa04130 snRNP Assembly REACT:R-HSA-191859 Sodium/Calcium exchangers REACT:R-HSA-425561 Sodium-coupled phosphate cotransporters REACT:R-HSA-427652 Sodium-coupled sulphate, di- and tri-carboxylate transporters REACT:R-HSA-433137 Sodium/Proton exchangers REACT:R-HSA-425986 SOS-mediated signalling REACT:R-HSA-112412 Sperm Motility And Taxes REACT:R-HSA-1300642 Sperm:Oocyte Membrane Binding REACT:R-HSA-1300652 S Phase REACT:R-HSA-69242 Sphingolipid de novo biosynthesis REACT:R-HSA-1660661 Sphingolipid metabolism KEGG:hsa00600 Sphingolipid metabolism REACT:R-HSA-428157 Sphingolipid signaling pathway KEGG:hsa04071 Sphingosine biosynthesis KEGG:hsa_M00099 Sphingosine degradation KEGG:hsa_M00100 Spliceosome KEGG:hsa03040 Spliceosome, 35S U5-snRNP KEGG:hsa_M00355 Spliceosome, Prp19/CDC5L complex KEGG:hsa_M00353 Spliceosome, U1-snRNP KEGG:hsa_M00351 Spliceosome, U2-snRNP KEGG:hsa_M00352 Spliceosome, U4/U6.U5 tri-snRNP KEGG:hsa_M00354 Spry regulation of FGF signaling REACT:R-HSA-1295596 SRP-dependent cotranslational protein targeting to membrane REACT:R-HSA-1799339 Stabilization of p53 REACT:R-HSA-69541 Staphylococcus aureus infection KEGG:hsa05150 Starch and sucrose metabolism KEGG:hsa00500 STAT6-mediated induction of chemokines REACT:R-HSA-3249367 Steroid biosynthesis KEGG:hsa00100 Steroid hormone biosynthesis KEGG:hsa00140 Steroid hormone biosynthesis, cholesterol => prognenolone => progesterone KEGG:hsa_M00107 Sterols are 12-hydroxylated by CYP8B1 REACT:R-HSA-211994 Stimulation of the cell death response by PAK-2p34 REACT:R-HSA-211736 Stimuli-sensing channels REACT:R-HSA-2672351 STING mediated induction of host immune responses REACT:R-HSA-1834941 Striated Muscle Contraction REACT:R-HSA-390522 Succinate dehydrogenase (ubiquinone) KEGG:hsa_M00148 Sulfide oxidation to sulfate REACT:R-HSA-1614517 Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid KEGG:hsa_M00067 Sulfur amino acid metabolism REACT:R-HSA-1614635 Sulfur metabolism KEGG:hsa00920 Sulfur relay system KEGG:hsa04122 SUMO E3 ligases SUMOylate target proteins REACT:R-HSA-3108232 SUMO is conjugated to E1 (UBA2:SAE1) REACT:R-HSA-3065676 SUMO is proteolytically processed REACT:R-HSA-3065679 SUMO is transferred from E1 to E2 (UBE2I, UBC9) REACT:R-HSA-3065678 SUMOylation REACT:R-HSA-2990846 SUMOylation of chromatin organization proteins REACT:R-HSA-4551638 SUMOylation of DNA damage response and repair proteins REACT:R-HSA-3108214 SUMOylation of DNA replication proteins REACT:R-HSA-4615885 SUMOylation of RNA binding proteins REACT:R-HSA-4570464 SUMOylation of transcription factors REACT:R-HSA-3232118 Surfactant metabolism REACT:R-HSA-5683826 Survival motor neuron (SMN) complex KEGG:hsa_M00426 Switching of origins to a post-replicative state REACT:R-HSA-69052 Synaptic vesicle cycle KEGG:hsa04721 Syndecan interactions REACT:R-HSA-3000170 Synthesis and degradation of ketone bodies KEGG:hsa00072 Synthesis and interconversion of nucleotide di- and triphosphates REACT:R-HSA-499943 Synthesis and processing of ENV and VPU REACT:R-HSA-171286 Synthesis And Processing Of GAG, GAGPOL Polyproteins REACT:R-HSA-174495 Synthesis of 12-eicosatetraenoic acid derivatives REACT:R-HSA-2142712 Synthesis of 15-eicosatetraenoic acid derivatives REACT:R-HSA-2142770 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) REACT:R-HSA-2142816 Synthesis of 5-eicosatetraenoic acids REACT:R-HSA-2142688 Synthesis of active ubiquitin: roles of E1 and E2 enzymes REACT:R-HSA-8866652 Synthesis of bile acids and bile salts REACT:R-HSA-192105 Synthesis of bile acids and bile salts via 24-hydroxycholesterol REACT:R-HSA-193775 Synthesis of bile acids and bile salts via 27-hydroxycholesterol REACT:R-HSA-193807 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol REACT:R-HSA-193368 Synthesis of BMP REACT:R-HSA-1483171 Synthesis of CL REACT:R-HSA-1483076 Synthesis of diphthamide-EEF2 REACT:R-HSA-5358493 Synthesis of DNA REACT:R-HSA-69239 Synthesis of Dolichyl-phosphate REACT:R-HSA-446199 Synthesis of dolichyl-phosphate-glucose REACT:R-HSA-480985 Synthesis of dolichyl-phosphate mannose REACT:R-HSA-162699 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) REACT:R-HSA-2142670 Synthesis of GDP-mannose REACT:R-HSA-446205 Synthesis of glycosylphosphatidylinositol (GPI) REACT:R-HSA-162710 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) REACT:R-HSA-2142696 Synthesis of IP2, IP, and Ins in the cytosol REACT:R-HSA-1855183 Synthesis of IP3 and IP4 in the cytosol REACT:R-HSA-1855204 Synthesis of IPs in the ER lumen REACT:R-HSA-1855231 Synthesis of IPs in the nucleus REACT:R-HSA-1855191 Synthesis of Ketone Bodies REACT:R-HSA-77111 Synthesis of Leukotrienes (LT) and Eoxins (EX) REACT:R-HSA-2142691 Synthesis of Lipoxins (LX) REACT:R-HSA-2142700 Synthesis of PA REACT:R-HSA-1483166 Synthesis of PC REACT:R-HSA-1483191 Synthesis of PE REACT:R-HSA-1483213 Synthesis of PG REACT:R-HSA-1483148 Synthesis of PI REACT:R-HSA-1483226 Synthesis of PIPs at the early endosome membrane REACT:R-HSA-1660516 Synthesis of PIPs at the ER membrane REACT:R-HSA-1483248 Synthesis of PIPs at the Golgi membrane REACT:R-HSA-1660514 Synthesis of PIPs at the late endosome membrane REACT:R-HSA-1660517 Synthesis of PIPs at the plasma membrane REACT:R-HSA-1660499 Synthesis of PIPs in the nucleus REACT:R-HSA-8847453 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) REACT:R-HSA-2162123 Synthesis of PS REACT:R-HSA-1483101 Synthesis of pyrophosphates in the cytosol REACT:R-HSA-1855167 Synthesis of substrates in N-glycan biosythesis REACT:R-HSA-446219 Synthesis of UDP-N-acetyl-glucosamine REACT:R-HSA-446210 Synthesis of very long-chain fatty acyl-CoAs REACT:R-HSA-75876 Synthesis of wybutosine at G37 of tRNA(Phe) REACT:R-HSA-6782861 Synthesis, secretion, and deacylation of Ghrelin REACT:R-HSA-422085 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) REACT:R-HSA-381771 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) REACT:R-HSA-400511 Systemic lupus erythematosus KEGG:hsa05322 t(4;14) translocations of FGFR3 REACT:R-HSA-2033515 T41 mutants of beta-catenin aren't phosphorylated REACT:R-HSA-5358752 Tachykinin receptors bind tachykinins REACT:R-HSA-380095 TAK1 activates NFkB by phosphorylation and activation of IKKs complex REACT:R-HSA-445989 TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P REACT:R-HSA-6791462 TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P REACT:R-HSA-6791055 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) REACT:R-HSA-1299308 Tandem pore domain halothane-inhibited K+ channel (THIK) REACT:R-HSA-1299287 Tandem pore domain potassium channels REACT:R-HSA-1296346 Taste transduction KEGG:hsa04742 Tat-mediated elongation of the HIV-1 transcript REACT:R-HSA-167246 Tat-mediated HIV elongation arrest and recovery REACT:R-HSA-167243 Taurine and hypotaurine metabolism KEGG:hsa00430 TBC/RABGAPs REACT:R-HSA-8854214 T cell receptor signaling pathway KEGG:hsa04660 TCF7L2 mutants don't bind CTBP REACT:R-HSA-5339700 TCF dependent signaling in response to WNT REACT:R-HSA-201681 TCR signaling REACT:R-HSA-202403 Telomere C-strand (Lagging Strand) Synthesis REACT:R-HSA-174417 Telomere C-strand synthesis initiation REACT:R-HSA-174430 Telomere Extension By Telomerase REACT:R-HSA-171319 Telomere Maintenance REACT:R-HSA-157579 Terminal pathway of complement REACT:R-HSA-166665 Termination of O-glycan biosynthesis REACT:R-HSA-977068 Termination of translesion DNA synthesis REACT:R-HSA-5656169 Terpenoid backbone biosynthesis KEGG:hsa00900 TET1,2,3 and TDG demethylate DNA REACT:R-HSA-5221030 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation REACT:R-HSA-1474151 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation REACT:R-HSA-8869496 TFAP2 (AP-2) family regulates transcription of cell cycle factors REACT:R-HSA-8866911 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors REACT:R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of other transcription factors REACT:R-HSA-8866906 TGF-beta receptor signaling activates SMADs REACT:R-HSA-2173789 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) REACT:R-HSA-2173791 TGF-beta signaling KEGG:hsa_M00680 TGF-beta signaling pathway KEGG:hsa04350 TGFBR1 KD Mutants in Cancer REACT:R-HSA-3656532 TGFBR1 LBD Mutants in Cancer REACT:R-HSA-3656535 TGFBR2 Kinase Domain Mutants in Cancer REACT:R-HSA-3645790 TGFBR2 MSI Frameshift Mutants in Cancer REACT:R-HSA-3642279 Th17 cell differentiation KEGG:hsa04659 Th1 and Th2 cell differentiation KEGG:hsa04658 THC complex KEGG:hsa_M00405 The activation of arylsulfatases REACT:R-HSA-1663150 The AIM2 inflammasome REACT:R-HSA-844615 The canonical retinoid cycle in rods (twilight vision) REACT:R-HSA-2453902 The citric acid (TCA) cycle and respiratory electron transport REACT:R-HSA-1428517 The fatty acid cycling model REACT:R-HSA-167826 The IPAF inflammasome REACT:R-HSA-844623 The NLRP1 inflammasome REACT:R-HSA-844455 The NLRP3 inflammasome REACT:R-HSA-844456 The phototransduction cascade REACT:R-HSA-2514856 The proton buffering model REACT:R-HSA-167827 The retinoid cycle in cones (daylight vision) REACT:R-HSA-2187335 The role of GTSE1 in G2/M progression after G2 checkpoint REACT:R-HSA-8852276 The role of Nef in HIV-1 replication and disease pathogenesis REACT:R-HSA-164952 Thiamine metabolism KEGG:hsa00730 Threonine catabolism REACT:R-HSA-8849175 Thrombin signalling through proteinase activated receptors (PARs) REACT:R-HSA-456926 Thromboxane signalling through TP receptor REACT:R-HSA-428930 Thyroid cancer KEGG:hsa05216 Thyroid hormone biosynthesis, tyrosine => triiodothyronine/thyroxine KEGG:hsa_M00043 Thyroid hormone signaling pathway KEGG:hsa04919 Thyroid hormone synthesis KEGG:hsa04918 Thyroxine biosynthesis REACT:R-HSA-209968 TICAM1 deficiency - HSE REACT:R-HSA-5602566 Tie2 Signaling REACT:R-HSA-210993 Tight junction KEGG:hsa04530 Tight junction interactions REACT:R-HSA-420029 TLR3 deficiency - HSE REACT:R-HSA-5602410 TNFR1-induced NFkappaB signaling pathway REACT:R-HSA-5357956 TNFR1-induced proapoptotic signaling REACT:R-HSA-5357786 TNFR1-mediated ceramide production REACT:R-HSA-5626978 TNFR2 non-canonical NF-kB pathway REACT:R-HSA-5668541 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway REACT:R-HSA-5676594 TNFs bind their physiological receptors REACT:R-HSA-5669034 TNF signaling REACT:R-HSA-75893 TNF signaling pathway KEGG:hsa04668 Tolerance by Mtb to nitric oxide produced by macrophages REACT:R-HSA-1222538 Tolerance of reactive oxygen produced by macrophages REACT:R-HSA-1222387 Toll Like Receptor 10 (TLR10) Cascade REACT:R-HSA-168142 Toll Like Receptor 2 (TLR2) Cascade REACT:R-HSA-181438 Toll Like Receptor 3 (TLR3) Cascade REACT:R-HSA-168164 Toll Like Receptor 4 (TLR4) Cascade REACT:R-HSA-166016 Toll Like Receptor 5 (TLR5) Cascade REACT:R-HSA-168176 Toll Like Receptor 7/8 (TLR7/8) Cascade REACT:R-HSA-168181 Toll Like Receptor 9 (TLR9) Cascade REACT:R-HSA-168138 Toll-Like Receptors Cascades REACT:R-HSA-168898 Toll-like receptor signaling KEGG:hsa_M00686 Toll-like receptor signaling pathway KEGG:hsa04620 Toll Like Receptor TLR1:TLR2 Cascade REACT:R-HSA-168179 Toll Like Receptor TLR6:TLR2 Cascade REACT:R-HSA-168188 Toxicity of botulinum toxin type A (BoNT/A) REACT:R-HSA-5250968 Toxicity of botulinum toxin type B (BoNT/B) REACT:R-HSA-5250958 Toxicity of botulinum toxin type C (BoNT/C) REACT:R-HSA-5250971 Toxicity of botulinum toxin type D (BoNT/D) REACT:R-HSA-5250955 Toxicity of botulinum toxin type E (BoNT/E) REACT:R-HSA-5250992 Toxicity of botulinum toxin type F (BoNT/F) REACT:R-HSA-5250981 Toxicity of botulinum toxin type G (BoNT/G) REACT:R-HSA-5250989 Toxicity of tetanus toxin (TeNT) REACT:R-HSA-5250982 Toxoplasmosis KEGG:hsa05145 TP53 Regulates Metabolic Genes REACT:R-HSA-5628897 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain REACT:R-HSA-6804115 TP53 Regulates Transcription of Caspase Activators and Caspases REACT:R-HSA-6803207 TP53 Regulates Transcription of Cell Cycle Genes REACT:R-HSA-6791312 TP53 Regulates Transcription of Cell Death Genes REACT:R-HSA-5633008 TP53 Regulates Transcription of Death Receptors and Ligands REACT:R-HSA-6803211 TP53 Regulates Transcription of DNA Repair Genes REACT:R-HSA-6796648 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release REACT:R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest REACT:R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest REACT:R-HSA-6804114 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain REACT:R-HSA-6803205 TRAF3 deficiency - HSE REACT:R-HSA-5602571 TRAF3-dependent IRF activation pathway REACT:R-HSA-918233 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation REACT:R-HSA-975138 TRAF6 mediated induction of TAK1 complex REACT:R-HSA-937072 TRAF6 mediated IRF7 activation REACT:R-HSA-933541 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling REACT:R-HSA-975110 TRAF6 mediated NF-kB activation REACT:R-HSA-933542 Trafficking and processing of endosomal TLR REACT:R-HSA-1679131 Trafficking of AMPA receptors REACT:R-HSA-399719 Trafficking of dietary sterols REACT:R-HSA-265473 Trafficking of GluR2-containing AMPA receptors REACT:R-HSA-416993 Trafficking of myristoylated proteins to the cilium REACT:R-HSA-5624138 TRAIL signaling REACT:R-HSA-75158 TRAMP complex KEGG:hsa_M00393 Transcriptional activation of cell cycle inhibitor p21 REACT:R-HSA-69895 Transcriptional activation of mitochondrial biogenesis REACT:R-HSA-2151201 Transcriptional activation of p53 responsive genes REACT:R-HSA-69560 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer REACT:R-HSA-2173793 Transcriptional misregulation in cancer KEGG:hsa05202 Transcriptional regulation by small RNAs REACT:R-HSA-5578749 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors REACT:R-HSA-8864260 Transcriptional Regulation by TP53 REACT:R-HSA-3700989 Transcriptional regulation of pluripotent stem cells REACT:R-HSA-452723 Transcriptional regulation of white adipocyte differentiation REACT:R-HSA-381340 Transcription-Coupled Nucleotide Excision Repair (TC-NER) REACT:R-HSA-6781827 Transcription from mitochondrial promoters REACT:R-HSA-75944 Transcription of the HIV genome REACT:R-HSA-167172 Transfer of LPS from LBP carrier to CD14 REACT:R-HSA-166020 Transferrin endocytosis and recycling REACT:R-HSA-917977 trans-Golgi Network Vesicle Budding REACT:R-HSA-199992 Translation REACT:R-HSA-72766 Translation initiation complex formation REACT:R-HSA-72649 Translesion Synthesis by POLH REACT:R-HSA-110320 Translesion synthesis by POLI REACT:R-HSA-5656121 Translesion synthesis by POLK REACT:R-HSA-5655862 Translesion synthesis by REV1 REACT:R-HSA-110312 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template REACT:R-HSA-110313 Translocation of GLUT4 to the plasma membrane REACT:R-HSA-1445148 Translocation of ZAP-70 to Immunological synapse REACT:R-HSA-202430 Translocon-associated protein (TRAP) complex KEGG:hsa_M00402 Transmembrane transport of small molecules REACT:R-HSA-382551 Transmission across Chemical Synapses REACT:R-HSA-112315 Transmission across Electrical Synapses REACT:R-HSA-112307 Transport and synthesis of PAPS REACT:R-HSA-174362 Transport of connexins along the secretory pathway REACT:R-HSA-190827 Transport of connexons to the plasma membrane REACT:R-HSA-190872 Transport of fatty acids REACT:R-HSA-804914 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus REACT:R-HSA-159763 Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds REACT:R-HSA-425366 Transport of glycerol from adipocytes to the liver by Aquaporins REACT:R-HSA-432030 Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus REACT:R-HSA-168874 Transport of inorganic cations/anions and amino acids/oligopeptides REACT:R-HSA-425393 Transport of Mature mRNA derived from an Intron-Containing Transcript REACT:R-HSA-159236 Transport of Mature mRNA Derived from an Intronless Transcript REACT:R-HSA-159231 Transport of Mature mRNAs Derived from Intronless Transcripts REACT:R-HSA-159234 Transport of Mature Transcript to Cytoplasm REACT:R-HSA-72202 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane REACT:R-HSA-83936 Transport of nucleotide sugars REACT:R-HSA-727802 Transport of organic anions REACT:R-HSA-879518 Transport of Ribonucleoproteins into the Host Nucleus REACT:R-HSA-168271 Transport of the SLBP Dependant Mature mRNA REACT:R-HSA-159230 Transport of the SLBP independent Mature mRNA REACT:R-HSA-159227 Transport of vitamins, nucleosides, and related molecules REACT:R-HSA-425397 Transport to the Golgi and subsequent modification REACT:R-HSA-948021 TREX complex KEGG:hsa_M00406 Triacylglycerol biosynthesis KEGG:hsa_M00089 TRIF-mediated programmed cell death REACT:R-HSA-2562578 TRIF-mediated TLR3/TLR4 signaling REACT:R-HSA-937061 Triglyceride Biosynthesis REACT:R-HSA-75109 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA REACT:R-HSA-450513 TRKA activation by NGF REACT:R-HSA-187042 tRNA Aminoacylation REACT:R-HSA-379724 tRNA modification in the mitochondrion REACT:R-HSA-6787450 tRNA modification in the nucleus and cytosol REACT:R-HSA-6782315 tRNA processing REACT:R-HSA-72306 tRNA processing in the mitochondrion REACT:R-HSA-6785470 tRNA processing in the nucleus REACT:R-HSA-6784531 TRP channels REACT:R-HSA-3295583 truncated APC mutants destabilize the destruction complex REACT:R-HSA-4839744 Truncations of AMER1 destabilize the destruction complex REACT:R-HSA-5467348 Tryptophan catabolism REACT:R-HSA-71240 Tryptophan metabolism KEGG:hsa00380 Tuberculosis KEGG:hsa05152 TWIK-related alkaline pH activated K+ channel (TALK) REACT:R-HSA-1299361 TWIK related potassium channel (TREK) REACT:R-HSA-1299503 TWIK-related spinal cord K+ channel (TRESK) REACT:R-HSA-1299344 TWIK-releated acid-sensitive K+ channel (TASK) REACT:R-HSA-1299316 Type I diabetes mellitus KEGG:hsa04940 Type I hemidesmosome assembly REACT:R-HSA-446107 Type II diabetes mellitus KEGG:hsa04930 Type II Na+/Pi cotransporters REACT:R-HSA-427589 Tyrosine degradation, tyrosine => homogentisate KEGG:hsa_M00044 Tyrosine metabolism KEGG:hsa00350 Ubiquinol biosynthesis REACT:R-HSA-2142789 Ubiquinone and other terpenoid-quinone biosynthesis KEGG:hsa00130 Ubiquinone biosynthesis, eukaryotes, 4-hydroxybenzoate => ubiquinone KEGG:hsa_M00128 Ubiquitin-dependent degradation of Cyclin D REACT:R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D1 REACT:R-HSA-69229 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A REACT:R-HSA-69601 Ubiquitin mediated proteolysis KEGG:hsa04120 Ub-specific processing proteases REACT:R-HSA-5689880 UCH proteinases REACT:R-HSA-5689603 Unblocking of NMDA receptor, glutamate binding and activation REACT:R-HSA-438066 UNC93B1 deficiency - HSE REACT:R-HSA-5602415 Uncoating of the HIV Virion REACT:R-HSA-162585 Uncoating of the Influenza Virion REACT:R-HSA-168336 Unfolded Protein Response (UPR) REACT:R-HSA-381119 Unwinding of DNA REACT:R-HSA-176974 Uptake and actions of bacterial toxins REACT:R-HSA-5339562 Uptake and function of anthrax toxins REACT:R-HSA-5210891 Uptake and function of diphtheria toxin REACT:R-HSA-5336415 Urea cycle KEGG:hsa_M00029 Urea cycle REACT:R-HSA-70635 Uridine monophosphate biosynthesis, glutamine (+ PRPP) => UMP KEGG:hsa_M00051 Utilization of Ketone Bodies REACT:R-HSA-77108 Valine, leucine and isoleucine biosynthesis KEGG:hsa00290 Valine, leucine and isoleucine degradation KEGG:hsa00280 Variant SLC6A14 may confer susceptibility towards obesity REACT:R-HSA-5619094 Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) REACT:R-HSA-5619101 Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) REACT:R-HSA-5660686 Vascular smooth muscle contraction KEGG:hsa04270 Vasopressin-like receptors REACT:R-HSA-388479 Vasopressin-regulated water reabsorption KEGG:hsa04962 Vasopressin regulates renal water homeostasis via Aquaporins REACT:R-HSA-432040 VEGFA-VEGFR2 Pathway REACT:R-HSA-4420097 VEGF binds to VEGFR leading to receptor dimerization REACT:R-HSA-195399 VEGF ligand-receptor interactions REACT:R-HSA-194313 VEGFR2 mediated cell proliferation REACT:R-HSA-5218921 VEGFR2 mediated vascular permeability REACT:R-HSA-5218920 VEGF signaling pathway KEGG:hsa04370 Vesicle-mediated transport REACT:R-HSA-5653656 Vibrio cholerae infection KEGG:hsa05110 Vif-mediated degradation of APOBEC3G REACT:R-HSA-180585 Viral carcinogenesis KEGG:hsa05203 Viral Messenger RNA Synthesis REACT:R-HSA-168325 Viral mRNA Translation REACT:R-HSA-192823 Viral myocarditis KEGG:hsa05416 Viral RNP Complexes in the Host Cell Nucleus REACT:R-HSA-168330 Virus Assembly and Release REACT:R-HSA-168268 Visual phototransduction REACT:R-HSA-2187338 Vitamin B1 (thiamin) metabolism REACT:R-HSA-196819 Vitamin B2 (riboflavin) metabolism REACT:R-HSA-196843 Vitamin B5 (pantothenate) metabolism REACT:R-HSA-199220 Vitamin B6 metabolism KEGG:hsa00750 Vitamin C (ascorbate) metabolism REACT:R-HSA-196836 Vitamin D (calciferol) metabolism REACT:R-HSA-196791 Vitamin digestion and absorption KEGG:hsa04977 Vitamins REACT:R-HSA-211916 Vitamins B6 activation to pyridoxal phosphate REACT:R-HSA-964975 VLDL biosynthesis REACT:R-HSA-8866423 VLDL interactions REACT:R-HSA-8855121 VLDLR internalisation and degradation REACT:R-HSA-8866427 Voltage gated Potassium channels REACT:R-HSA-1296072 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization REACT:R-HSA-180897 Vpr-mediated nuclear import of PICs REACT:R-HSA-180910 Vpu mediated degradation of CD4 REACT:R-HSA-180534 vRNA Synthesis REACT:R-HSA-192814 vRNP Assembly REACT:R-HSA-192905 V-type ATPase, eukaryotes KEGG:hsa_M00160 VxPx cargo-targeting to cilium REACT:R-HSA-5620916 Wax biosynthesis REACT:R-HSA-8848584 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 REACT:R-HSA-5140745 WNT5A-dependent internalization of FZD4 REACT:R-HSA-5099900 WNT ligand biogenesis and trafficking REACT:R-HSA-3238698 WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 REACT:R-HSA-5340573 WNT mediated activation of DVL REACT:R-HSA-201688 Wnt signaling KEGG:hsa_M00677 Wnt signaling pathway KEGG:hsa04310 XAV939 inhibits tankyrase, stabilizing AXIN REACT:R-HSA-5545619 XBP1(S) activates chaperone genes REACT:R-HSA-381038 Xenobiotics REACT:R-HSA-211981 YAP1- and WWTR1 (TAZ)-stimulated gene expression REACT:R-HSA-2032785 ZBP1(DAI) mediated induction of type I IFNs REACT:R-HSA-1606322 Zinc efflux and compartmentalization by the SLC30 family REACT:R-HSA-435368 Zinc influx into cells by the SLC39 gene family REACT:R-HSA-442380 Zinc transporters REACT:R-HSA-435354