diff --git "a/node/CTD_pathways.tsv" "b/node/CTD_pathways.tsv" new file mode 100644--- /dev/null +++ "b/node/CTD_pathways.tsv" @@ -0,0 +1,2596 @@ +# The Comparative Toxicogenomics Database (CTD) - http://ctdbase.org/ +# Copyright 2002-2012 MDI Biological Laboratory. All rights reserved. +# Copyright 2012-2023 NC State University. All rights reserved. +# +# +# Use is subject to the terms set forth at http://ctdbase.org/about/legal.jsp +# These terms include: +# +# 1. All forms of publication (e.g., web sites, research papers, databases, +# software applications, etc.) that use or rely on CTD data must cite CTD. +# Citation guidelines: http://ctdbase.org/about/publications/#citing +# +# 2. All electronic or online applications must include hyperlinks from +# contexts that use CTD data to the applicable CTD data pages. +# Linking instructions: http://ctdbase.org/help/linking.jsp +# +# 3. You must notify CTD, and describe your use of our data: +# http://ctdbase.org/help/contact.go +# +# 4. For quality control purposes, you must provide CTD with periodic +# access to your publication of our data. +# +# More information: http://ctdbase.org/downloads/ +# +# Report created: Fri Oct 27 12:42:19 EDT 2023 +# +# Fields: +# PathwayName PathwayID +# +2-LTR circle formation REACT:R-HSA-164843 +2-Oxocarboxylic acid metabolism KEGG:hsa01210 +5-Phosphoribose 1-diphosphate biosynthesis REACT:R-HSA-73843 +Abacavir metabolism REACT:R-HSA-2161541 +Abacavir transmembrane transport REACT:R-HSA-2161517 +Abacavir transport and metabolism REACT:R-HSA-2161522 +Abasic sugar-phosphate removal via the single-nucleotide replacement pathway REACT:R-HSA-73930 +ABC-family proteins mediated transport REACT:R-HSA-382556 +ABC transporter disorders REACT:R-HSA-5619084 +ABC transporters KEGG:hsa02010 +ABC transporters in lipid homeostasis REACT:R-HSA-1369062 +Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate REACT:R-HSA-2978092 +Abortive elongation of HIV-1 transcript in the absence of Tat REACT:R-HSA-167242 +Acetylation REACT:R-HSA-156582 +Acetylcholine Binding And Downstream Events REACT:R-HSA-181431 +Acetylcholine Neurotransmitter Release Cycle REACT:R-HSA-264642 +Acetylcholine regulates insulin secretion REACT:R-HSA-399997 +Acrosome Reaction REACT:R-HSA-1300645 +Activated NOTCH1 Transmits Signal to the Nucleus REACT:R-HSA-2122948 +Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 REACT:R-HSA-5625886 +Activated point mutants of FGFR2 REACT:R-HSA-2033519 +activated TAK1 mediates p38 MAPK activation REACT:R-HSA-450302 +Activated TLR4 signalling REACT:R-HSA-166054 +Activation and oligomerization of BAK protein REACT:R-HSA-111452 +Activation, myristolyation of BID and translocation to mitochondria REACT:R-HSA-75108 +Activation of AKT2 REACT:R-HSA-165158 +Activation of AMPA receptors REACT:R-HSA-399710 +Activation of anterior HOX genes in hindbrain development during early embryogenesis REACT:R-HSA-5617472 +Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins REACT:R-HSA-176814 +Activation of ATR in response to replication stress REACT:R-HSA-176187 +Activation of BAD and translocation to mitochondria REACT:R-HSA-111447 +Activation of BH3-only proteins REACT:R-HSA-114452 +Activation of BIM and translocation to mitochondria REACT:R-HSA-111446 +Activation of BMF and translocation to mitochondria REACT:R-HSA-139910 +Activation of C3 and C5 REACT:R-HSA-174577 +Activation of CaMK IV REACT:R-HSA-442745 +Activation of Ca-permeable Kainate Receptor REACT:R-HSA-451308 +Activation of caspases through apoptosome-mediated cleavage REACT:R-HSA-111459 +Activation of DNA fragmentation factor REACT:R-HSA-211227 +Activation of GABAB receptors REACT:R-HSA-991365 +Activation of gene expression by SREBF (SREBP) REACT:R-HSA-2426168 +Activation of G protein gated Potassium channels REACT:R-HSA-1296041 +Activation of HOX genes during differentiation REACT:R-HSA-5619507 +Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon REACT:R-HSA-936964 +Activation of Kainate Receptors upon glutamate binding REACT:R-HSA-451326 +Activation of Matrix Metalloproteinases REACT:R-HSA-1592389 +Activation of Na-permeable Kainate Receptors REACT:R-HSA-451307 +Activation of NF-kappaB in B cells REACT:R-HSA-1169091 +Activation of Nicotinic Acetylcholine Receptors REACT:R-HSA-629602 +Activation of NIMA Kinases NEK9, NEK6, NEK7 REACT:R-HSA-2980767 +Activation of NMDA receptor upon glutamate binding and postsynaptic events REACT:R-HSA-442755 +Activation of NOXA and translocation to mitochondria REACT:R-HSA-111448 +Activation of PPARGC1A (PGC-1alpha) by phosphorylation REACT:R-HSA-2151209 +Activation of PUMA and translocation to mitochondria REACT:R-HSA-139915 +Activation of Rac REACT:R-HSA-428540 +Activation of RAS in B cells REACT:R-HSA-1169092 +Activation of SMO REACT:R-HSA-5635838 +Activation of the AP-1 family of transcription factors REACT:R-HSA-450341 +Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S REACT:R-HSA-72662 +Activation of the phototransduction cascade REACT:R-HSA-2485179 +Activation of the pre-replicative complex REACT:R-HSA-68962 +Activation of the TFAP2 (AP-2) family of transcription factors REACT:R-HSA-8866907 +Activation of TRKA receptors REACT:R-HSA-187015 +Activation, translocation and oligomerization of BAX REACT:R-HSA-114294 +Activin signaling KEGG:hsa_M00681 +Acute myeloid leukemia KEGG:hsa05221 +Acyl chain remodeling of CL REACT:R-HSA-1482798 +Acyl chain remodeling of DAG and TAG REACT:R-HSA-1482883 +Acyl chain remodelling of PC REACT:R-HSA-1482788 +Acyl chain remodelling of PE REACT:R-HSA-1482839 +Acyl chain remodelling of PG REACT:R-HSA-1482925 +Acyl chain remodelling of PI REACT:R-HSA-1482922 +Acyl chain remodelling of PS REACT:R-HSA-1482801 +Acylglycerol degradation KEGG:hsa_M00098 +Adaptive Immune System REACT:R-HSA-1280218 +Adenine ribonucleotide biosynthesis, IMP => ADP,ATP KEGG:hsa_M00049 +Adenosine P1 receptors REACT:R-HSA-417973 +Adenylate cyclase activating pathway REACT:R-HSA-170660 +Adenylate cyclase inhibitory pathway REACT:R-HSA-170670 +Adherens junction KEGG:hsa04520 +Adherens junctions interactions REACT:R-HSA-418990 +Adipocytokine signaling pathway KEGG:hsa04920 +ADP signalling through P2Y purinoceptor 1 REACT:R-HSA-418592 +ADP signalling through P2Y purinoceptor 12 REACT:R-HSA-392170 +Adrenaline,noradrenaline inhibits insulin secretion REACT:R-HSA-400042 +Adrenaline signalling through Alpha-2 adrenergic receptor REACT:R-HSA-392023 +Adrenergic signaling in cardiomyocytes KEGG:hsa04261 +Adrenoceptors REACT:R-HSA-390696 +Advanced glycosylation endproduct receptor signaling REACT:R-HSA-879415 +Aflatoxin activation and detoxification REACT:R-HSA-5423646 +African trypanosomiasis KEGG:hsa05143 +AGE-RAGE signaling pathway in diabetic complications KEGG:hsa04933 +Agmatine biosynthesis REACT:R-HSA-351143 +AKT-mediated inactivation of FOXO1A REACT:R-HSA-211163 +AKT phosphorylates targets in the cytosol REACT:R-HSA-198323 +AKT phosphorylates targets in the nucleus REACT:R-HSA-198693 +Alanine, aspartate and glutamate metabolism KEGG:hsa00250 +Alcoholism KEGG:hsa05034 +Aldosterone-regulated sodium reabsorption KEGG:hsa04960 +Aldosterone synthesis and secretion KEGG:hsa04925 +ALKBH2 mediated reversal of alkylation damage REACT:R-HSA-112122 +ALKBH3 mediated reversal of alkylation damage REACT:R-HSA-112126 +Allograft rejection KEGG:hsa05330 +Alpha-defensins REACT:R-HSA-1462054 +alpha-linolenic acid (ALA) metabolism REACT:R-HSA-2046106 +alpha-Linolenic acid metabolism KEGG:hsa00592 +alpha-linolenic (omega3) and linoleic (omega6) acid metabolism REACT:R-HSA-2046104 +Alpha-oxidation of phytanate REACT:R-HSA-389599 +Alternative complement activation REACT:R-HSA-173736 +Alzheimer's disease KEGG:hsa05010 +AMER1 mutants destabilize the destruction complex REACT:R-HSA-4839748 +Amine-derived hormones REACT:R-HSA-209776 +Amine ligand-binding receptors REACT:R-HSA-375280 +Amine Oxidase reactions REACT:R-HSA-140179 +Amino Acid conjugation REACT:R-HSA-156587 +Amino acid synthesis and interconversion (transamination) REACT:R-HSA-70614 +Amino acid transport across the plasma membrane REACT:R-HSA-352230 +Aminoacyl-tRNA biosynthesis KEGG:hsa00970 +Aminoacyl-tRNA biosynthesis, eukaryotes KEGG:hsa_M00359 +Amino sugar and nucleotide sugar metabolism KEGG:hsa00520 +Amoebiasis KEGG:hsa05146 +Amphetamine addiction KEGG:hsa05031 +AMPK inhibits chREBP transcriptional activation activity REACT:R-HSA-163680 +AMPK signaling pathway KEGG:hsa04152 +Amplification of signal from the kinetochores REACT:R-HSA-141424 +Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal REACT:R-HSA-141444 +Amyloid fiber formation REACT:R-HSA-977225 +Amyotrophic lateral sclerosis (ALS) KEGG:hsa05014 +Anchoring fibril formation REACT:R-HSA-2214320 +Anchoring of the basal body to the plasma membrane REACT:R-HSA-5620912 +Androgen biosynthesis REACT:R-HSA-193048 +Antagonism of Activin by Follistatin REACT:R-HSA-2473224 +Antifolate resistance KEGG:hsa01523 +Antigen activates B Cell Receptor (BCR) leading to generation of second messengers REACT:R-HSA-983695 +Antigen Presentation: Folding, assembly and peptide loading of class I MHC REACT:R-HSA-983170 +Antigen processing and presentation KEGG:hsa04612 +Antigen processing-Cross presentation REACT:R-HSA-1236975 +Antigen processing: Ubiquitination & Proteasome degradation REACT:R-HSA-983168 +Antimicrobial peptides REACT:R-HSA-6803157 +Antiviral mechanism by IFN-stimulated genes REACT:R-HSA-1169410 +APC/C:Cdc20 mediated degradation of Cyclin B REACT:R-HSA-174048 +APC/C:Cdc20 mediated degradation of mitotic proteins REACT:R-HSA-176409 +APC/C:Cdc20 mediated degradation of Securin REACT:R-HSA-174154 +APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 REACT:R-HSA-174178 +APC/C complex KEGG:hsa_M00389 +APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint REACT:R-HSA-179419 +APC-Cdc20 mediated degradation of Nek2A REACT:R-HSA-179409 +APC/C-mediated degradation of cell cycle proteins REACT:R-HSA-174143 +APC truncation mutants are not K63 polyubiquitinated REACT:R-HSA-5467333 +APC truncation mutants have impaired AXIN binding REACT:R-HSA-5467337 +Apelin signaling pathway KEGG:hsa04371 +APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway REACT:R-HSA-5649702 +APOBEC3G mediated resistance to HIV-1 infection REACT:R-HSA-180689 +Apoptosis KEGG:hsa04210 +Apoptosis REACT:R-HSA-109581 +Apoptosis induced DNA fragmentation REACT:R-HSA-140342 +Apoptosis - multiple species KEGG:hsa04215 +Apoptotic cleavage of cell adhesion proteins REACT:R-HSA-351906 +Apoptotic cleavage of cellular proteins REACT:R-HSA-111465 +Apoptotic execution phase REACT:R-HSA-75153 +Apoptotic factor-mediated response REACT:R-HSA-111471 +Apoptotic machinery KEGG:hsa_M00685 +Aquaporin-mediated transport REACT:R-HSA-445717 +Arachidonate production from DAG REACT:R-HSA-426048 +Arachidonic acid metabolism KEGG:hsa00590 +Arachidonic acid metabolism REACT:R-HSA-2142753 +Arginine and proline metabolism KEGG:hsa00330 +Arginine biosynthesis KEGG:hsa00220 +ARL13B-mediated ciliary trafficking of INPP5E REACT:R-HSA-5624958 +ARMS-mediated activation REACT:R-HSA-170984 +Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 REACT:R-HSA-211957 +Arrhythmogenic right ventricular cardiomyopathy (ARVC) KEGG:hsa05412 +Aryl hydrocarbon receptor signalling REACT:R-HSA-8937144 +Ascorbate and aldarate metabolism KEGG:hsa00053 +Asparagine N-linked glycosylation REACT:R-HSA-446203 +Assembly of collagen fibrils and other multimeric structures REACT:R-HSA-2022090 +Assembly Of The HIV Virion REACT:R-HSA-175474 +Assembly of the ORC complex at the origin of replication REACT:R-HSA-68616 +Assembly of the pre-replicative complex REACT:R-HSA-68867 +Assembly of Viral Components at the Budding Site REACT:R-HSA-168316 +Association of licensing factors with the pre-replicative complex REACT:R-HSA-69298 +Association of TriC/CCT with target proteins during biosynthesis REACT:R-HSA-390471 +Asthma KEGG:hsa05310 +Astrocytic Glutamate-Glutamine Uptake And Metabolism REACT:R-HSA-210455 +Asymmetric localization of PCP proteins REACT:R-HSA-4608870 +A tetrasaccharide linker sequence is required for GAG synthesis REACT:R-HSA-1971475 +ATF4 activates genes REACT:R-HSA-380994 +ATF6 (ATF6-alpha) activates chaperone genes REACT:R-HSA-381183 +ATF6 (ATF6-alpha) activates chaperones REACT:R-HSA-381033 +ATP sensitive Potassium channels REACT:R-HSA-1296025 +Attachment of GPI anchor to uPAR REACT:R-HSA-162791 +Attenuation phase REACT:R-HSA-3371568 +AUF1 (hnRNP D0) binds and destabilizes mRNA REACT:R-HSA-450408 +AURKA Activation by TPX2 REACT:R-HSA-8854518 +Autodegradation of Cdh1 by Cdh1:APC/C REACT:R-HSA-174084 +Autodegradation of the E3 ubiquitin ligase COP1 REACT:R-HSA-349425 +Autoimmune thyroid disease KEGG:hsa05320 +Autointegration results in viral DNA circles REACT:R-HSA-177539 +Autophagy - animal KEGG:hsa04140 +Autophagy - other KEGG:hsa04136 +AXIN missense mutants destabilize the destruction complex REACT:R-HSA-5467340 +AXIN mutants destabilize the destruction complex, activating WNT signaling REACT:R-HSA-4839735 +Axonal growth inhibition (RHOA activation) REACT:R-HSA-193634 +Axonal growth stimulation REACT:R-HSA-209563 +Axon guidance KEGG:hsa04360 +Axon guidance REACT:R-HSA-422475 +Bacterial invasion of epithelial cells KEGG:hsa05100 +Basal cell carcinoma KEGG:hsa05217 +Basal transcription factors KEGG:hsa03022 +Base excision repair KEGG:hsa03410 +Base Excision Repair REACT:R-HSA-73884 +Base-Excision Repair, AP Site Formation REACT:R-HSA-73929 +Basigin interactions REACT:R-HSA-210991 +BBSome-mediated cargo-targeting to cilium REACT:R-HSA-5620922 +B cell receptor signaling pathway KEGG:hsa04662 +BER complex KEGG:hsa_M00296 +beta-Alanine metabolism KEGG:hsa00410 +Beta-catenin independent WNT signaling REACT:R-HSA-3858494 +Beta-catenin phosphorylation cascade REACT:R-HSA-196299 +Beta defensins REACT:R-HSA-1461957 +betaKlotho-mediated ligand binding REACT:R-HSA-1307965 +beta-Oxidation KEGG:hsa_M00087 +beta-Oxidation, acyl-CoA synthesis KEGG:hsa_M00086 +Beta oxidation of butanoyl-CoA to acetyl-CoA REACT:R-HSA-77352 +Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA REACT:R-HSA-77346 +Beta oxidation of hexanoyl-CoA to butanoyl-CoA REACT:R-HSA-77350 +Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA REACT:R-HSA-77310 +Beta oxidation of myristoyl-CoA to lauroyl-CoA REACT:R-HSA-77285 +Beta oxidation of octanoyl-CoA to hexanoyl-CoA REACT:R-HSA-77348 +Beta oxidation of palmitoyl-CoA to myristoyl-CoA REACT:R-HSA-77305 +Beta-oxidation of pristanoyl-CoA REACT:R-HSA-389887 +Beta-oxidation of very long chain fatty acids REACT:R-HSA-390247 +BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members REACT:R-HSA-111453 +Bicarbonate transporters REACT:R-HSA-425381 +Bile acid and bile salt metabolism REACT:R-HSA-194068 +Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate KEGG:hsa_M00104 +Bile secretion KEGG:hsa04976 +Binding and entry of HIV virion REACT:R-HSA-173107 +Binding and Uptake of Ligands by Scavenger Receptors REACT:R-HSA-2173782 +Binding of TCF/LEF:CTNNB1 to target gene promoters REACT:R-HSA-4411364 +Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB REACT:R-HSA-141333 +Biological oxidations REACT:R-HSA-211859 +Biosynthesis of A2E, implicated in retinal degradation REACT:R-HSA-2466712 +Biosynthesis of amino acids KEGG:hsa01230 +Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein REACT:R-HSA-446193 +Biosynthesis of unsaturated fatty acids KEGG:hsa01040 +Biotin metabolism KEGG:hsa00780 +Biotin transport and metabolism REACT:R-HSA-196780 +Bladder cancer KEGG:hsa05219 +Bloom's syndrome complex KEGG:hsa_M00414 +BMAL1:CLOCK,NPAS2 activates circadian gene expression REACT:R-HSA-1368108 +BMP signaling KEGG:hsa_M00679 +Branched-chain amino acid catabolism REACT:R-HSA-70895 +BRCA1-associated genome surveillance complex (BASC) KEGG:hsa_M00295 +Breakdown of the nuclear lamina REACT:R-HSA-352238 +Breast cancer KEGG:hsa05224 +Budding REACT:R-HSA-168302 +Budding and maturation of HIV virion REACT:R-HSA-162588 +Butanoate metabolism KEGG:hsa00650 +Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA REACT:R-HSA-450385 +Butyrophilin (BTN) family interactions REACT:R-HSA-8851680 +B-WICH complex positively regulates rRNA expression REACT:R-HSA-5250924 +C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone KEGG:hsa_M00110 +C1-unit interconversion, eukaryotes KEGG:hsa_M00141 +C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone KEGG:hsa_M00108 +C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone KEGG:hsa_M00109 +C5 isoprenoid biosynthesis, mevalonate pathway KEGG:hsa_M00095 +C6 deamination of adenosine REACT:R-HSA-75102 +Ca2+ activated K+ channels REACT:R-HSA-1296052 +Ca2+ pathway REACT:R-HSA-4086398 +Ca-dependent events REACT:R-HSA-111996 +Caffeine metabolism KEGG:hsa00232 +Calcitonin-like ligand receptors REACT:R-HSA-419812 +Calcium signaling pathway KEGG:hsa04020 +Calmodulin induced events REACT:R-HSA-111933 +Calnexin/calreticulin cycle REACT:R-HSA-901042 +CaMK IV-mediated phosphorylation of CREB REACT:R-HSA-111932 +CaM pathway REACT:R-HSA-111997 +Cam-PDE 1 activation REACT:R-HSA-111957 +cAMP signaling KEGG:hsa_M00695 +cAMP signaling pathway KEGG:hsa04024 +Cap binding complex KEGG:hsa_M00399 +Cap-dependent Translation Initiation REACT:R-HSA-72737 +Carbohydrate digestion and absorption KEGG:hsa04973 +Carbon metabolism KEGG:hsa01200 +Cardiac conduction REACT:R-HSA-5576891 +Cardiac muscle contraction KEGG:hsa04260 +Cargo concentration in the ER REACT:R-HSA-5694530 +Cargo recognition for clathrin-mediated endocytosis REACT:R-HSA-8856825 +Cargo trafficking to the periciliary membrane REACT:R-HSA-5620920 +Carnitine synthesis REACT:R-HSA-71262 +CASP8 activity is inhibited REACT:R-HSA-5218900 +Caspase activation via extrinsic apoptotic signalling pathway REACT:R-HSA-5357769 +Caspase-mediated cleavage of cytoskeletal proteins REACT:R-HSA-264870 +Catabolism of glucuronate to xylulose-5-phosphate REACT:R-HSA-5661270 +Catecholamine biosynthesis REACT:R-HSA-209905 +Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline KEGG:hsa_M00042 +Cation-coupled Chloride cotransporters REACT:R-HSA-426117 +CD209 (DC-SIGN) signaling REACT:R-HSA-5621575 +CD22 mediated BCR regulation REACT:R-HSA-5690714 +CD28 co-stimulation REACT:R-HSA-389356 +CD28 dependent PI3K/Akt signaling REACT:R-HSA-389357 +CD28 dependent Vav1 pathway REACT:R-HSA-389359 +Cdc20:Phospho-APC/C mediated degradation of Cyclin A REACT:R-HSA-174184 +CDC6 association with the ORC:origin complex REACT:R-HSA-68689 +CDK-mediated phosphorylation and removal of Cdc6 REACT:R-HSA-69017 +CDO in myogenesis REACT:R-HSA-375170 +CDT1 association with the CDC6:ORC:origin complex REACT:R-HSA-68827 +Cell adhesion molecules (CAMs) KEGG:hsa04514 +Cell-Cell communication REACT:R-HSA-1500931 +Cell-cell junction organization REACT:R-HSA-421270 +Cell cycle KEGG:hsa04110 +Cell Cycle REACT:R-HSA-1640170 +Cell Cycle Checkpoints REACT:R-HSA-69620 +Cell cycle - G1/S transition KEGG:hsa_M00692 +Cell cycle - G2/M transition KEGG:hsa_M00693 +Cell Cycle, Mitotic REACT:R-HSA-69278 +Cell death signalling via NRAGE, NRIF and NADE REACT:R-HSA-204998 +Cell-extracellular matrix interactions REACT:R-HSA-446353 +Cell junction organization REACT:R-HSA-446728 +Cell redox homeostasis REACT:R-HSA-1222541 +Cell surface interactions at the vascular wall REACT:R-HSA-202733 +Cellular responses to stress REACT:R-HSA-2262752 +Cellular response to heat stress REACT:R-HSA-3371556 +Cellular response to hypoxia REACT:R-HSA-2262749 +Cellular Senescence REACT:R-HSA-2559583 +Central carbon metabolism in cancer KEGG:hsa05230 +Centrosome maturation REACT:R-HSA-380287 +Ceramide biosynthesis KEGG:hsa_M00094 +Ceramide signalling REACT:R-HSA-193681 +cGMP effects REACT:R-HSA-418457 +cGMP-PKG signaling pathway KEGG:hsa04022 +cGMP signaling KEGG:hsa_M00694 +Chagas disease (American trypanosomiasis) KEGG:hsa05142 +Chaperonin-mediated protein folding REACT:R-HSA-390466 +Chemical carcinogenesis KEGG:hsa05204 +Chemokine receptors bind chemokines REACT:R-HSA-380108 +Chemokine signaling pathway KEGG:hsa04062 +Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex REACT:R-HSA-75035 +CHL1 interactions REACT:R-HSA-447041 +Cholecalciferol biosynthesis KEGG:hsa_M00103 +Cholesterol biosynthesis REACT:R-HSA-191273 +Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterol KEGG:hsa_M00101 +Cholesterol biosynthesis via desmosterol REACT:R-HSA-6807047 +Cholesterol biosynthesis via lathosterol REACT:R-HSA-6807062 +Choline catabolism REACT:R-HSA-6798163 +Choline metabolism in cancer KEGG:hsa05231 +Cholinergic synapse KEGG:hsa04725 +Chondroitin sulfate biosynthesis REACT:R-HSA-2022870 +Chondroitin sulfate degradation KEGG:hsa_M00077 +Chondroitin sulfate/dermatan sulfate metabolism REACT:R-HSA-1793185 +ChREBP activates metabolic gene expression REACT:R-HSA-163765 +Chromatin modifying enzymes REACT:R-HSA-3247509 +Chromatin organization REACT:R-HSA-4839726 +Chromosome Maintenance REACT:R-HSA-73886 +Chronic myeloid leukemia KEGG:hsa05220 +Chylomicron-mediated lipid transport REACT:R-HSA-174800 +Cilium Assembly REACT:R-HSA-5617833 +Circadian Clock REACT:R-HSA-400253 +Circadian entrainment KEGG:hsa04713 +Circadian rhythm KEGG:hsa04710 +Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate KEGG:hsa_M00010 +Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate KEGG:hsa_M00011 +Citrate cycle (TCA cycle) KEGG:hsa00020 +Citrate cycle (TCA cycle, Krebs cycle) KEGG:hsa_M00009 +Citric acid cycle (TCA cycle) REACT:R-HSA-71403 +Class A/1 (Rhodopsin-like receptors) REACT:R-HSA-373076 +Class B/2 (Secretin family receptors) REACT:R-HSA-373080 +Class C/3 (Metabotropic glutamate/pheromone receptors) REACT:R-HSA-420499 +Classical antibody-mediated complement activation REACT:R-HSA-173623 +Classical Kir channels REACT:R-HSA-1296053 +Class II GLUTs REACT:R-HSA-428776 +Class I MHC mediated antigen processing & presentation REACT:R-HSA-983169 +Clathrin derived vesicle budding REACT:R-HSA-421837 +Clathrin-mediated endocytosis REACT:R-HSA-8856828 +Clearance of Nuclear Envelope Membranes from Chromatin REACT:R-HSA-2993913 +Cleavage of Growing Transcript in the Termination Region REACT:R-HSA-109688 +Cleavage of the damaged purine REACT:R-HSA-110331 +Cleavage of the damaged pyrimidine REACT:R-HSA-110329 +CLEC7A (Dectin-1) induces NFAT activation REACT:R-HSA-5607763 +CLEC7A (Dectin-1) signaling REACT:R-HSA-5607764 +CLEC7A/inflammasome pathway REACT:R-HSA-5660668 +Cobalamin (Cbl, vitamin B12) transport and metabolism REACT:R-HSA-196741 +Cocaine addiction KEGG:hsa05030 +Coenzyme A biosynthesis REACT:R-HSA-196783 +Coenzyme A biosynthesis, pantothenate => CoA KEGG:hsa_M00120 +Cohesin Loading onto Chromatin REACT:R-HSA-2470946 +Collagen biosynthesis and modifying enzymes REACT:R-HSA-1650814 +Collagen chain trimerization REACT:R-HSA-8948216 +Collagen degradation REACT:R-HSA-1442490 +Collagen formation REACT:R-HSA-1474290 +Collecting duct acid secretion KEGG:hsa04966 +Colorectal cancer KEGG:hsa05210 +Common Pathway of Fibrin Clot Formation REACT:R-HSA-140875 +Complement and coagulation cascades KEGG:hsa04610 +Complement cascade REACT:R-HSA-166658 +Complex I biogenesis REACT:R-HSA-6799198 +Condensation of Prometaphase Chromosomes REACT:R-HSA-2514853 +Condensation of Prophase Chromosomes REACT:R-HSA-2299718 +Conjugated bile acid biosynthesis, cholate => taurocholate/glycocholate KEGG:hsa_M00106 +Conjugation of benzoate with glycine REACT:R-HSA-177135 +Conjugation of carboxylic acids REACT:R-HSA-159424 +Conjugation of phenylacetate with glutamine REACT:R-HSA-177162 +Conjugation of salicylate with glycine REACT:R-HSA-177128 +Constitutive Signaling by Aberrant PI3K in Cancer REACT:R-HSA-2219530 +Constitutive Signaling by AKT1 E17K in Cancer REACT:R-HSA-5674400 +Constitutive Signaling by EGFRvIII REACT:R-HSA-5637810 +Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants REACT:R-HSA-1236382 +Constitutive Signaling by NOTCH1 HD Domain Mutants REACT:R-HSA-2691232 +Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants REACT:R-HSA-2894862 +Constitutive Signaling by NOTCH1 PEST Domain Mutants REACT:R-HSA-2644606 +Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant REACT:R-HSA-2660826 +Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase REACT:R-HSA-176407 +Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding REACT:R-HSA-6814122 +Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding REACT:R-HSA-389958 +COPI-dependent Golgi-to-ER retrograde traffic REACT:R-HSA-6811434 +COPII (Coat Protein 2) Mediated Vesicle Transport REACT:R-HSA-204005 +COPII complex KEGG:hsa_M00404 +COPI-independent Golgi-to-ER retrograde traffic REACT:R-HSA-6811436 +COPI-mediated anterograde transport REACT:R-HSA-6807878 +Costimulation by the CD28 family REACT:R-HSA-388841 +COX reactions REACT:R-HSA-140180 +Creatine metabolism REACT:R-HSA-71288 +Creatine pathway KEGG:hsa_M00047 +Creation of C4 and C2 activators REACT:R-HSA-166786 +CREB phosphorylation REACT:R-HSA-199920 +CREB phosphorylation through the activation of Adenylate Cyclase REACT:R-HSA-442720 +CREB phosphorylation through the activation of CaMKII REACT:R-HSA-442729 +CREB phosphorylation through the activation of CaMKK REACT:R-HSA-442717 +CREB phosphorylation through the activation of Ras REACT:R-HSA-442742 +CRMPs in Sema3A signaling REACT:R-HSA-399956 +cRNA Synthesis REACT:R-HSA-192869 +Crosslinking of collagen fibrils REACT:R-HSA-2243919 +Cross-presentation of particulate exogenous antigens (phagosomes) REACT:R-HSA-1236973 +Cross-presentation of soluble exogenous antigens (endosomes) REACT:R-HSA-1236978 +CS/DS degradation REACT:R-HSA-2024101 +c-src mediated regulation of Cx43 function and closure of gap junctions REACT:R-HSA-191647 +CTLA4 inhibitory signaling REACT:R-HSA-389513 +C-type lectin receptors (CLRs) REACT:R-HSA-5621481 +Cul3-SPOP complex KEGG:hsa_M00384 +Cul4-DDB1-CSA complex KEGG:hsa_M00386 +Cul4-DDB1-DDB2 complex KEGG:hsa_M00385 +Cyclin A/B1 associated events during G2/M transition REACT:R-HSA-69273 +Cyclin A:Cdk2-associated events at S phase entry REACT:R-HSA-69656 +Cyclin B2 mediated events REACT:R-HSA-157881 +Cyclin D associated events in G1 REACT:R-HSA-69231 +Cyclin E associated events during G1/S transition REACT:R-HSA-69202 +CYP2E1 reactions REACT:R-HSA-211999 +Cysteine and methionine metabolism KEGG:hsa00270 +Cysteine biosynthesis, homocysteine + serine => cysteine KEGG:hsa_M00338 +Cysteine formation from homocysteine REACT:R-HSA-1614603 +Cytochrome bc1 complex KEGG:hsa_M00152 +Cytochrome bc1 complex respiratory unit KEGG:hsa_M00151 +Cytochrome c-mediated apoptotic response REACT:R-HSA-111461 +Cytochrome c oxidase KEGG:hsa_M00154 +Cytochrome P450 - arranged by substrate type REACT:R-HSA-211897 +Cytokine-cytokine receptor interaction KEGG:hsa04060 +Cytokine Signaling in Immune system REACT:R-HSA-1280215 +Cytosolic DNA-sensing pathway KEGG:hsa04623 +Cytosolic iron-sulfur cluster assembly REACT:R-HSA-2564830 +Cytosolic sensors of pathogen-associated DNA REACT:R-HSA-1834949 +Cytosolic sulfonation of small molecules REACT:R-HSA-156584 +Cytosolic tRNA aminoacylation REACT:R-HSA-379716 +DAG and IP3 signaling REACT:R-HSA-1489509 +DAP12 interactions REACT:R-HSA-2172127 +DAP12 signaling REACT:R-HSA-2424491 +D-Arginine and D-ornithine metabolism KEGG:hsa00472 +DARPP-32 events REACT:R-HSA-180024 +DCC mediated attractive signaling REACT:R-HSA-418885 +Deactivation of the beta-catenin transactivating complex REACT:R-HSA-3769402 +Deadenylation-dependent mRNA decay REACT:R-HSA-429914 +Deadenylation of mRNA REACT:R-HSA-429947 +Death Receptor Signalling REACT:R-HSA-73887 +Decapping complex KEGG:hsa_M00395 +Dectin-1 mediated noncanonical NF-kB signaling REACT:R-HSA-5607761 +Dectin-2 family REACT:R-HSA-5621480 +Defective ABCA12 causes autosomal recessive congenital ichthyosis type 4B REACT:R-HSA-5682294 +Defective ABCA1 causes Tangier disease REACT:R-HSA-5682113 +Defective ABCA3 causes pulmonary surfactant metabolism dysfunction 3 (SMDP3) REACT:R-HSA-5688399 +Defective ABCA3 causes pulmonary surfactant metabolism dysfunction type 3 (SMDP3) REACT:R-HSA-5683678 +Defective ABCB11 causes progressive familial intrahepatic cholestasis 2 and benign recurrent intrahepatic cholestasis 2 REACT:R-HSA-5678520 +Defective ABCB4 causes progressive familial intrahepatic cholestasis 3, intrahepatic cholestasis of pregnancy 3 and gallbladder disease 1 REACT:R-HSA-5678771 +Defective ABCB6 causes isolated colobomatous microphthalmia 7 (MCOPCB7) REACT:R-HSA-5683371 +Defective ABCC2 causes Dubin-Johnson syndrome REACT:R-HSA-5679001 +Defective ABCC6 causes pseudoxanthoma elasticum (PXE) REACT:R-HSA-5690338 +Defective ABCC8 can cause hypoglycemias and hyperglycemias REACT:R-HSA-5683177 +Defective ABCC9 causes dilated cardiomyopathy 10, familial atrial fibrillation 12 and hypertrichotic osteochondrodysplasia REACT:R-HSA-5678420 +Defective ABCD1 causes adrenoleukodystrophy (ALD) REACT:R-HSA-5684045 +Defective ABCD4 causes methylmalonic aciduria and homocystinuria, cblj type (MAHCJ) REACT:R-HSA-5683329 +Defective ABCG5 causes sitosterolemia REACT:R-HSA-5679096 +Defective ABCG8 causes gallbladder disease 4 and sitosterolemia REACT:R-HSA-5679090 +Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) REACT:R-HSA-5579031 +Defective ACY1 causes encephalopathy REACT:R-HSA-5579007 +Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) REACT:R-HSA-5578997 +Defective ALG11 causes ALG11-CDG (CDG-1p) REACT:R-HSA-4551295 +Defective ALG12 causes ALG12-CDG (CDG-1g) REACT:R-HSA-4720489 +Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) REACT:R-HSA-5633231 +Defective ALG1 causes ALG1-CDG (CDG-1k) REACT:R-HSA-4549380 +Defective ALG2 causes ALG2-CDG (CDG-1i) REACT:R-HSA-4549349 +Defective ALG3 causes ALG3-CDG (CDG-1d) REACT:R-HSA-4720475 +Defective ALG6 causes ALG6-CDG (CDG-1c) REACT:R-HSA-4724289 +Defective ALG8 causes ALG8-CDG (CDG-1h) REACT:R-HSA-4724325 +Defective ALG9 causes ALG9-CDG (CDG-1l) REACT:R-HSA-4720454 +Defective AMN causes hereditary megaloblastic anemia 1 REACT:R-HSA-3359462 +Defective AVP causes neurohypophyseal diabetes insipidus (NDI) REACT:R-HSA-5619099 +Defective B3GALT6 causes EDSP2 and SEMDJL1 REACT:R-HSA-4420332 +Defective B3GALTL causes Peters-plus syndrome (PpS) REACT:R-HSA-5083635 +Defective B3GAT3 causes JDSSDHD REACT:R-HSA-3560801 +Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) REACT:R-HSA-3656244 +Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) REACT:R-HSA-4793953 +Defective B4GALT7 causes EDS, progeroid type REACT:R-HSA-3560783 +Defective BTD causes biotidinase deficiency REACT:R-HSA-3371598 +Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) REACT:R-HSA-5083632 +Defective CD320 causes methylmalonic aciduria REACT:R-HSA-3359485 +Defective CFTR causes cystic fibrosis REACT:R-HSA-5678895 +Defective CHST14 causes EDS, musculocontractural type REACT:R-HSA-3595174 +Defective CHST3 causes SEDCJD REACT:R-HSA-3595172 +Defective CHST6 causes MCDC1 REACT:R-HSA-3656225 +Defective CHSY1 causes TPBS REACT:R-HSA-3595177 +Defective CP causes aceruloplasminemia (ACERULOP) REACT:R-HSA-5619060 +Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4) REACT:R-HSA-5688890 +Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5) REACT:R-HSA-5688849 +Defective CUBN causes hereditary megaloblastic anemia 1 REACT:R-HSA-3359463 +Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) REACT:R-HSA-5579026 +Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) REACT:R-HSA-5579017 +Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) REACT:R-HSA-5579009 +Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) REACT:R-HSA-5579028 +Defective CYP19A1 causes Aromatase excess syndrome (AEXS) REACT:R-HSA-5579030 +Defective CYP1B1 causes Glaucoma REACT:R-HSA-5579000 +Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3) REACT:R-HSA-5579021 +Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) REACT:R-HSA-5579010 +Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) REACT:R-HSA-5579015 +Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) REACT:R-HSA-5579004 +Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) REACT:R-HSA-5578996 +Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) REACT:R-HSA-5579014 +Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) REACT:R-HSA-5579027 +Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) REACT:R-HSA-5579011 +Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) REACT:R-HSA-5579005 +Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) REACT:R-HSA-5579013 +Defective DHDDS causes retinitis pigmentosa 59 REACT:R-HSA-4755609 +Defective DOLK causes DOLK-CDG (CDG-1m) REACT:R-HSA-4755583 +Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 REACT:R-HSA-4549356 +Defective DPM1 causes DPM1-CDG (CDG-1e) REACT:R-HSA-4717374 +Defective DPM2 causes DPM2-CDG (CDG-1u) REACT:R-HSA-4719377 +Defective DPM3 causes DPM3-CDG (CDG-1o) REACT:R-HSA-4719360 +Defective EXT1 causes exostoses 1, TRPS2 and CHDS REACT:R-HSA-3656253 +Defective EXT2 causes exostoses 2 REACT:R-HSA-3656237 +Defective FMO3 causes Trimethylaminuria (TMAU) REACT:R-HSA-5579019 +Defective GALE can cause Epimerase-deficiency galactosemia (EDG) REACT:R-HSA-5609977 +Defective GALK1 can cause Galactosemia II (GALCT2) REACT:R-HSA-5609976 +Defective GALNT12 causes colorectal cancer 1 (CRCS1) REACT:R-HSA-5083636 +Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) REACT:R-HSA-5083625 +Defective GALT can cause Galactosemia REACT:R-HSA-5609978 +Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) REACT:R-HSA-5619073 +Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) REACT:R-HSA-5578999 +Defective GFPT1 causes CMSTA1 REACT:R-HSA-4085023 +Defective GGT1 causes Glutathionuria (GLUTH) REACT:R-HSA-5579022 +Defective GIF causes intrinsic factor deficiency REACT:R-HSA-3359457 +Defective GNE causes sialuria, Nonaka myopathy and inclusion body myopathy 2 REACT:R-HSA-4085011 +Defective GSS causes Glutathione synthetase deficiency (GSS deficiency) REACT:R-HSA-5579006 +Defective HK1 causes hexokinase deficiency (HK deficiency) REACT:R-HSA-5619056 +Defective HLCS causes multiple carboxylase deficiency REACT:R-HSA-3371599 +Defective LARGE causes MDDGA6 and MDDGB6 REACT:R-HSA-5083627 +Defective LFNG causes SCDO3 REACT:R-HSA-5083630 +Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF REACT:R-HSA-3359458 +Defective MAN1B1 causes MRT15 REACT:R-HSA-4793950 +Defective MAOA causes Brunner syndrome (BRUNS) REACT:R-HSA-5579012 +Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) REACT:R-HSA-5579024 +Defective MGAT2 causes MGAT2-CDG (CDG-2a) REACT:R-HSA-4793952 +Defective MMAA causes methylmalonic aciduria type cblA REACT:R-HSA-3359475 +Defective MMAB causes methylmalonic aciduria type cblB REACT:R-HSA-3359471 +Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC REACT:R-HSA-3359474 +Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD REACT:R-HSA-3359473 +Defective MOGS causes MOGS-CDG (CDG-2b) REACT:R-HSA-4793954 +Defective MPDU1 causes MPDU1-CDG (CDG-1f) REACT:R-HSA-4687000 +Defective MPI causes MPI-CDG (CDG-1b) REACT:R-HSA-4043916 +Defective MTR causes methylmalonic aciduria and homocystinuria type cblG REACT:R-HSA-3359469 +Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE REACT:R-HSA-3359467 +Defective MUT causes methylmalonic aciduria mut type REACT:R-HSA-3359478 +Defective NEU1 causes sialidosis REACT:R-HSA-4341670 +Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) REACT:R-HSA-5578998 +Defective PAPSS2 causes SEMD-PA REACT:R-HSA-3560796 +Defective PGM1 causes PGM1-CDG (CDG1t) REACT:R-HSA-5609974 +Defective PMM2 causes PMM2-CDG (CDG-1a) REACT:R-HSA-4043911 +Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 REACT:R-HSA-5083628 +Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 REACT:R-HSA-5083633 +Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 REACT:R-HSA-5083629 +Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS) REACT:R-HSA-5688031 +Defective pro-SFTPC causes pulmonary surfactant metabolism dysfunction 2 (SMDP2) and respiratory distress syndrome (RDS) REACT:R-HSA-5688354 +Defective RFT1 causes RFT1-CDG (CDG-1n) REACT:R-HSA-4570571 +Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN) REACT:R-HSA-5619042 +Defective SFTPA2 causes idiopathic pulmonary fibrosis (IPF) REACT:R-HSA-5687868 +Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) REACT:R-HSA-5619048 +Defective SLC12A1 causes Bartter syndrome 1 (BS1) REACT:R-HSA-5619104 +Defective SLC12A3 causes Gitelman syndrome (GS) REACT:R-HSA-5619087 +Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) REACT:R-HSA-5619039 +Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) REACT:R-HSA-5619070 +Defective SLC17A5 causes Salla disease (SD) and ISSD REACT:R-HSA-5619035 +Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25) REACT:R-HSA-5619076 +Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) REACT:R-HSA-5619067 +Defective SLC1A3 causes episodic ataxia 6 (EA6) REACT:R-HSA-5619062 +Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) REACT:R-HSA-5619111 +Defective SLC22A12 causes renal hypouricemia 1 (RHUC1) REACT:R-HSA-5619071 +Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1) REACT:R-HSA-5619066 +Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP) REACT:R-HSA-5619053 +Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D) REACT:R-HSA-5619077 +Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI) REACT:R-HSA-5619055 +Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6) REACT:R-HSA-5619036 +Defective SLC26A2 causes chondrodysplasias REACT:R-HSA-3560792 +Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1) REACT:R-HSA-5619085 +Defective SLC26A4 causes Pendred syndrome (PDS) REACT:R-HSA-5619046 +Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) REACT:R-HSA-5619108 +Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS) REACT:R-HSA-5619063 +Defective SLC2A10 causes arterial tortuosity syndrome (ATS) REACT:R-HSA-5619068 +Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) REACT:R-HSA-5619043 +Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) REACT:R-HSA-5619098 +Defective SLC2A9 causes hypouricemia renal 2 (RHUC2) REACT:R-HSA-5619047 +Defective SLC33A1 causes spastic paraplegia 42 (SPG42) REACT:R-HSA-5619061 +Defective SLC34A1 causes hypophosphatemic nephrolithiasis/osteoporosis 1 (NPHLOP1) REACT:R-HSA-5619040 +Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) REACT:R-HSA-5619045 +Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) REACT:R-HSA-5687583 +Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) REACT:R-HSA-5619097 +Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) REACT:R-HSA-5619037 +Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) REACT:R-HSA-5663020 +Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M) REACT:R-HSA-5619072 +Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS) REACT:R-HSA-5619083 +Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C) REACT:R-HSA-5619078 +Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) REACT:R-HSA-5579020 +Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG) REACT:R-HSA-5619041 +Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ) REACT:R-HSA-5619088 +Defective SLC3A1 causes cystinuria (CSNU) REACT:R-HSA-5619113 +Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) REACT:R-HSA-5655799 +Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) REACT:R-HSA-5619049 +Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) REACT:R-HSA-5619050 +Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) REACT:R-HSA-5619054 +Defective SLC5A1 causes congenital glucose/galactose malabsorption (GGM) REACT:R-HSA-5656364 +Defective SLC5A2 causes renal glucosuria (GLYS1) REACT:R-HSA-5658208 +Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1) REACT:R-HSA-5619096 +Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) REACT:R-HSA-5619114 +Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) REACT:R-HSA-5658471 +Defective SLC6A18 may confer susceptibility to iminoglycinuria and/or hyperglycinuria REACT:R-HSA-5619079 +Defective SLC6A18 may confer susceptibility to iminoglycinuria and/or hyperglycinuria REACT:R-HSA-5659729 +Defective SLC6A19 causes Hartnup disorder (HND) REACT:R-HSA-5619044 +Defective SLC6A19 causes Hartnup disorder (HND) REACT:R-HSA-5659735 +Defective SLC6A2 causes orthostatic intolerance (OI) REACT:R-HSA-5619109 +Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) REACT:R-HSA-5619081 +Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) REACT:R-HSA-5660724 +Defective SLC6A5 causes hyperekplexia 3 (HKPX3) REACT:R-HSA-5619089 +Defective SLC7A7 causes lysinuric protein intolerance (LPI) REACT:R-HSA-5660862 +Defective SLC7A9 causes cystinuria (CSNU) REACT:R-HSA-5660883 +Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH) REACT:R-HSA-5619092 +Defective SLC9A9 causes autism 16 (AUTS16) REACT:R-HSA-5619052 +Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) REACT:R-HSA-5619110 +Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) REACT:R-HSA-5661182 +Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) REACT:R-HSA-5619058 +Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2) REACT:R-HSA-5619095 +Defective SRD5A3 causes SRD5A3-CDG (CDG-1q) and KHRZ REACT:R-HSA-4755579 +Defective ST3GAL3 causes MCT12 and EIEE15 REACT:R-HSA-3656243 +Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) REACT:R-HSA-5579032 +Defective TCN2 causes hereditary megaloblastic anemia REACT:R-HSA-3359454 +Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) REACT:R-HSA-5578995 +Defective TRP may confer susceptibility towards thyroid papillary carcinoma (TPC) REACT:R-HSA-5619107 +Defective UGT1A1 causes hyperbilirubinemia REACT:R-HSA-5579002 +Defective UGT1A4 causes hyperbilirubinemia REACT:R-HSA-5579016 +Defects in biotin (Btn) metabolism REACT:R-HSA-3323169 +Defects in cobalamin (B12) metabolism REACT:R-HSA-3296469 +Defects in vitamin and cofactor metabolism REACT:R-HSA-3296482 +Defensins REACT:R-HSA-1461973 +Degradation of AXIN REACT:R-HSA-4641257 +Degradation of beta-catenin by the destruction complex REACT:R-HSA-195253 +Degradation of cysteine and homocysteine REACT:R-HSA-1614558 +Degradation of DVL REACT:R-HSA-4641258 +Degradation of GABA REACT:R-HSA-916853 +Degradation of GLI1 by the proteasome REACT:R-HSA-5610780 +Degradation of GLI2 by the proteasome REACT:R-HSA-5610783 +Degradation of the extracellular matrix REACT:R-HSA-1474228 +Deletions in the AMER1 gene destabilize the destruction complex REACT:R-HSA-5467343 +Deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling REACT:R-HSA-5467345 +Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels REACT:R-HSA-112308 +Depolymerisation of the Nuclear Lamina REACT:R-HSA-4419969 +Deposition of new CENPA-containing nucleosomes at the centromere REACT:R-HSA-606279 +Depurination REACT:R-HSA-73927 +Depyrimidination REACT:R-HSA-73928 +Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models REACT:R-HSA-8862803 +Dermatan sulfate biosynthesis REACT:R-HSA-2022923 +Dermatan sulfate degradation KEGG:hsa_M00076 +Detoxification of Reactive Oxygen Species REACT:R-HSA-3299685 +Deubiquitination REACT:R-HSA-5688426 +Developmental Biology REACT:R-HSA-1266738 +DEx/H-box helicases activate type I IFN and inflammatory cytokines production REACT:R-HSA-3134963 +D-Glutamine and D-glutamate metabolism KEGG:hsa00471 +Digestion of dietary carbohydrate REACT:R-HSA-189085 +Digestion of dietary lipid REACT:R-HSA-192456 +Dilated cardiomyopathy KEGG:hsa05414 +Dimerization of procaspase-8 REACT:R-HSA-69416 +Disassembly of the destruction complex and recruitment of AXIN to the membrane REACT:R-HSA-4641262 +Disease REACT:R-HSA-1643685 +Diseases associated with glycosaminoglycan metabolism REACT:R-HSA-3560782 +Diseases associated with glycosylation precursor biosynthesis REACT:R-HSA-5609975 +Diseases associated with N-glycosylation of proteins REACT:R-HSA-3781860 +Diseases associated with O-glycosylation of proteins REACT:R-HSA-3906995 +Diseases associated with surfactant metabolism REACT:R-HSA-5687613 +Diseases associated with the TLR signaling cascade REACT:R-HSA-5602358 +Diseases associated with visual transduction REACT:R-HSA-2474795 +Diseases of carbohydrate metabolism REACT:R-HSA-5663084 +Diseases of glycosylation REACT:R-HSA-3781865 +Diseases of Immune System REACT:R-HSA-5260271 +Diseases of metabolism REACT:R-HSA-5668914 +Diseases of signal transduction REACT:R-HSA-5663202 +Disinhibition of SNARE formation REACT:R-HSA-114516 +Disorders of transmembrane transporters REACT:R-HSA-5619115 +Displacement of DNA glycosylase by APEX1 REACT:R-HSA-110357 +Dissolution of Fibrin Clot REACT:R-HSA-75205 +DNA Damage Bypass REACT:R-HSA-73893 +DNA damage-induced cell cycle checkpoints KEGG:hsa_M00691 +DNA Damage Recognition in GG-NER REACT:R-HSA-5696394 +DNA Damage Reversal REACT:R-HSA-73942 +DNA Damage/Telomere Stress Induced Senescence REACT:R-HSA-2559586 +DNA Double-Strand Break Repair REACT:R-HSA-5693532 +DNA Double Strand Break Response REACT:R-HSA-5693606 +DNA methylation REACT:R-HSA-5334118 +DNA-PK complex KEGG:hsa_M00297 +DNA polymerase alpha / primase complex KEGG:hsa_M00261 +DNA polymerase delta complex KEGG:hsa_M00262 +DNA polymerase epsilon complex KEGG:hsa_M00263 +DNA polymerase gamma complex KEGG:hsa_M00294 +DNA polymerase zeta complex KEGG:hsa_M00293 +DNA Repair REACT:R-HSA-73894 +DNA replication KEGG:hsa03030 +DNA Replication REACT:R-HSA-69306 +DNA replication initiation REACT:R-HSA-68952 +DNA Replication Pre-Initiation REACT:R-HSA-69002 +DNA strand elongation REACT:R-HSA-69190 +Dopamine clearance from the synaptic cleft REACT:R-HSA-379401 +Dopamine Neurotransmitter Release Cycle REACT:R-HSA-212676 +Dopamine receptors REACT:R-HSA-390651 +Dopaminergic synapse KEGG:hsa04728 +Dorso-ventral axis formation KEGG:hsa04320 +Downregulation of ERBB2:ERBB3 signaling REACT:R-HSA-1358803 +Downregulation of ERBB2 signaling REACT:R-HSA-8863795 +Downregulation of ERBB4 signaling REACT:R-HSA-1253288 +Downregulation of SMAD2/3:SMAD4 transcriptional activity REACT:R-HSA-2173795 +Downregulation of TGF-beta receptor signaling REACT:R-HSA-2173788 +Downstream signaling events of B Cell Receptor (BCR) REACT:R-HSA-1168372 +Downstream signaling of activated FGFR1 REACT:R-HSA-5654687 +Downstream signaling of activated FGFR2 REACT:R-HSA-5654696 +Downstream signaling of activated FGFR3 REACT:R-HSA-5654708 +Downstream signaling of activated FGFR4 REACT:R-HSA-5654716 +Downstream signal transduction REACT:R-HSA-186763 +Downstream TCR signaling REACT:R-HSA-202424 +Drug metabolism - cytochrome P450 KEGG:hsa00982 +Drug metabolism - other enzymes KEGG:hsa00983 +DSCAM interactions REACT:R-HSA-376172 +Dual Incision in GG-NER REACT:R-HSA-5696400 +Dual incision in TC-NER REACT:R-HSA-6782135 +E2F-enabled inhibition of pre-replication complex formation REACT:R-HSA-113507 +E2F mediated regulation of DNA replication REACT:R-HSA-113510 +E3 ubiquitin ligases ubiquitinate target proteins REACT:R-HSA-8866654 +Early Phase of HIV Life Cycle REACT:R-HSA-162594 +ECM proteoglycans REACT:R-HSA-3000178 +ECM-receptor interaction KEGG:hsa04512 +ECS complex KEGG:hsa_M00388 +ECV complex KEGG:hsa_M00383 +Effects of PIP2 hydrolysis REACT:R-HSA-114508 +EGFR downregulation REACT:R-HSA-182971 +EGFR interacts with phospholipase C-gamma REACT:R-HSA-212718 +EGFR Transactivation by Gastrin REACT:R-HSA-2179392 +EGFR tyrosine kinase inhibitor resistance KEGG:hsa01521 +Eicosanoid ligand-binding receptors REACT:R-HSA-391903 +Eicosanoids REACT:R-HSA-211979 +eIF4F complex KEGG:hsa_M00428 +Elastic fibre formation REACT:R-HSA-1566948 +Electric Transmission Across Gap Junctions REACT:R-HSA-112303 +Electron transport from NADPH to Ferredoxin REACT:R-HSA-2395516 +Elevation of cytosolic Ca2+ levels REACT:R-HSA-139853 +Endocrine and other factor-regulated calcium reabsorption KEGG:hsa04961 +Endocrine resistance KEGG:hsa01522 +Endocytosis KEGG:hsa04144 +Endogenous sterols REACT:R-HSA-211976 +Endometrial cancer KEGG:hsa05213 +Endosomal Sorting Complex Required For Transport (ESCRT) REACT:R-HSA-917729 +Endosomal/Vacuolar pathway REACT:R-HSA-1236977 +Energy dependent regulation of mTOR by LKB1-AMPK REACT:R-HSA-380972 +eNOS activation REACT:R-HSA-203615 +eNOS activation and regulation REACT:R-HSA-203765 +Entry of Influenza Virion into Host Cell via Endocytosis REACT:R-HSA-168275 +Enzymatic degradation of dopamine by COMT REACT:R-HSA-379397 +Enzymatic degradation of Dopamine by monoamine oxidase REACT:R-HSA-379398 +EPHA-mediated growth cone collapse REACT:R-HSA-3928663 +EPHB-mediated forward signaling REACT:R-HSA-3928662 +EPH-ephrin mediated repulsion of cells REACT:R-HSA-3928665 +EPH-Ephrin signaling REACT:R-HSA-2682334 +Ephrin signaling REACT:R-HSA-3928664 +Epigenetic regulation of gene expression REACT:R-HSA-212165 +Epithelial cell signaling in Helicobacter pylori infection KEGG:hsa05120 +Epstein-Barr virus infection KEGG:hsa05169 +ERBB2 Activates PTK6 Signaling REACT:R-HSA-8847993 +ERBB2 Regulates Cell Motility REACT:R-HSA-6785631 +ErbB signaling pathway KEGG:hsa04012 +ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression REACT:R-HSA-427389 +ERK/MAPK targets REACT:R-HSA-198753 +ERKs are inactivated REACT:R-HSA-202670 +ER-Phagosome pathway REACT:R-HSA-1236974 +ER Quality Control Compartment (ERQC) REACT:R-HSA-901032 +ER to Golgi Anterograde Transport REACT:R-HSA-199977 +Erythrocytes take up carbon dioxide and release oxygen REACT:R-HSA-1237044 +Erythrocytes take up oxygen and release carbon dioxide REACT:R-HSA-1247673 +ESCRT-0 complex KEGG:hsa_M00408 +ESCRT-I complex KEGG:hsa_M00409 +ESCRT-II complex KEGG:hsa_M00410 +ESCRT-III complex KEGG:hsa_M00412 +Essential fructosuria REACT:R-HSA-5657562 +Essential pentosuria REACT:R-HSA-5662853 +Establishment of Sister Chromatid Cohesion REACT:R-HSA-2468052 +Estrogen biosynthesis REACT:R-HSA-193144 +Estrogen signaling pathway KEGG:hsa04915 +Ethanol oxidation REACT:R-HSA-71384 +Ether lipid metabolism KEGG:hsa00565 +Eukaryotic Translation Elongation REACT:R-HSA-156842 +Eukaryotic Translation Initiation REACT:R-HSA-72613 +Eukaryotic Translation Termination REACT:R-HSA-72764 +Exon junction complex (EJC) KEGG:hsa_M00430 +Exosome, archaea KEGG:hsa_M00390 +Exosome, eukaryotes KEGG:hsa_M00391 +Export of Viral Ribonucleoproteins from Nucleus REACT:R-HSA-168274 +Extension of Telomeres REACT:R-HSA-180786 +Extracellular matrix organization REACT:R-HSA-1474244 +Extrinsic Pathway of Fibrin Clot Formation REACT:R-HSA-140834 +Facilitative Na+-independent glucose transporters REACT:R-HSA-428790 +FA core complex KEGG:hsa_M00413 +Factors involved in megakaryocyte development and platelet production REACT:R-HSA-983231 +Fanconi anemia pathway KEGG:hsa03460 +Fanconi Anemia Pathway REACT:R-HSA-6783310 +FasL/ CD95L signaling REACT:R-HSA-75157 +Fat digestion and absorption KEGG:hsa04975 +Fatty acid biosynthesis KEGG:hsa00061 +Fatty acid biosynthesis, elongation KEGG:hsa_M00083 +Fatty acid biosynthesis, elongation, endoplasmic reticulum KEGG:hsa_M00415 +Fatty acid biosynthesis, elongation, mitochondria KEGG:hsa_M00085 +Fatty acid biosynthesis, initiation KEGG:hsa_M00082 +Fatty acid degradation KEGG:hsa00071 +Fatty acid elongation KEGG:hsa00062 +Fatty acid metabolism KEGG:hsa01212 +Fatty acids REACT:R-HSA-211935 +Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion REACT:R-HSA-434316 +Fatty acid, triacylglycerol, and ketone body metabolism REACT:R-HSA-535734 +Fatty Acyl-CoA Biosynthesis REACT:R-HSA-75105 +FBXL7 down-regulates AURKA during mitotic entry and in early mitosis REACT:R-HSA-8854050 +FBXW7 Mutants and NOTCH1 in Cancer REACT:R-HSA-2644605 +Fc epsilon receptor (FCERI) signaling REACT:R-HSA-2454202 +Fc epsilon RI signaling pathway KEGG:hsa04664 +FCERI mediated Ca+2 mobilization REACT:R-HSA-2871809 +FCERI mediated MAPK activation REACT:R-HSA-2871796 +FCERI mediated NF-kB activation REACT:R-HSA-2871837 +Fcgamma receptor (FCGR) dependent phagocytosis REACT:R-HSA-2029480 +Fc gamma R-mediated phagocytosis KEGG:hsa04666 +FCGR activation REACT:R-HSA-2029481 +Ferroptosis KEGG:hsa04216 +Fertilization REACT:R-HSA-1187000 +FGFR1b ligand binding and activation REACT:R-HSA-190370 +FGFR1c and Klotho ligand binding and activation REACT:R-HSA-190374 +FGFR1c ligand binding and activation REACT:R-HSA-190373 +FGFR1 ligand binding and activation REACT:R-HSA-190242 +FGFR1 mutant receptor activation REACT:R-HSA-1839124 +FGFR2 alternative splicing REACT:R-HSA-6803529 +FGFR2b ligand binding and activation REACT:R-HSA-190377 +FGFR2c ligand binding and activation REACT:R-HSA-190375 +FGFR2 ligand binding and activation REACT:R-HSA-190241 +FGFR2 mutant receptor activation REACT:R-HSA-1839126 +FGFR3b ligand binding and activation REACT:R-HSA-190371 +FGFR3c ligand binding and activation REACT:R-HSA-190372 +FGFR3 ligand binding and activation REACT:R-HSA-190239 +FGFR3 mutant receptor activation REACT:R-HSA-2033514 +FGFR4 ligand binding and activation REACT:R-HSA-190322 +FGFR4 mutant receptor activation REACT:R-HSA-1839128 +FGFRL1 modulation of FGFR1 signaling REACT:R-HSA-5658623 +Fibronectin matrix formation REACT:R-HSA-1566977 +Ficolins bind to repetitive carbohydrate structures on the target cell surface REACT:R-HSA-2855086 +Fluid shear stress and atherosclerosis KEGG:hsa05418 +FMO oxidises nucleophiles REACT:R-HSA-217271 +Focal adhesion KEGG:hsa04510 +Folate biosynthesis KEGG:hsa00790 +Folding of actin by CCT/TriC REACT:R-HSA-390450 +Formation of annular gap junctions REACT:R-HSA-196025 +Formation of a pool of free 40S subunits REACT:R-HSA-72689 +Formation of apoptosome REACT:R-HSA-111458 +Formation of ATP by chemiosmotic coupling REACT:R-HSA-163210 +Formation of editosomes by ADAR proteins REACT:R-HSA-77042 +Formation of Fibrin Clot (Clotting Cascade) REACT:R-HSA-140877 +Formation of HIV-1 elongation complex containing HIV-1 Tat REACT:R-HSA-167200 +Formation of HIV elongation complex in the absence of HIV Tat REACT:R-HSA-167152 +Formation of Incision Complex in GG-NER REACT:R-HSA-5696395 +Formation of RNA Pol II elongation complex REACT:R-HSA-112382 +Formation of selenosugars for excretion REACT:R-HSA-2408499 +Formation of Senescence-Associated Heterochromatin Foci (SAHF) REACT:R-HSA-2559584 +Formation of TC-NER Pre-Incision Complex REACT:R-HSA-6781823 +Formation of the active cofactor, UDP-glucuronate REACT:R-HSA-173599 +Formation of the beta-catenin:TCF transactivating complex REACT:R-HSA-201722 +Formation of the cornified envelope REACT:R-HSA-6809371 +Formation of the Early Elongation Complex REACT:R-HSA-113418 +Formation of the Editosome REACT:R-HSA-75094 +Formation of the HIV-1 Early Elongation Complex REACT:R-HSA-167158 +Formation of the ternary complex, and subsequently, the 43S complex REACT:R-HSA-72695 +Formation of tubulin folding intermediates by CCT/TriC REACT:R-HSA-389960 +Formyl peptide receptors bind formyl peptides and many other ligands REACT:R-HSA-444473 +FoxO signaling pathway KEGG:hsa04068 +Free fatty acid receptors REACT:R-HSA-444209 +Free fatty acids regulate insulin secretion REACT:R-HSA-400451 +Frs2-mediated activation REACT:R-HSA-170968 +FRS-mediated FGFR1 signaling REACT:R-HSA-5654693 +FRS-mediated FGFR2 signaling REACT:R-HSA-5654700 +FRS-mediated FGFR3 signaling REACT:R-HSA-5654706 +FRS-mediated FGFR4 signaling REACT:R-HSA-5654712 +Fructose and mannose metabolism KEGG:hsa00051 +Fructose biosynthesis REACT:R-HSA-5652227 +Fructose catabolism REACT:R-HSA-70350 +Fructose metabolism REACT:R-HSA-5652084 +F-type ATPase, eukaryotes KEGG:hsa_M00158 +Fusion and Uncoating of the Influenza Virion REACT:R-HSA-168270 +Fusion of the Influenza Virion to the Host Cell Endosome REACT:R-HSA-168288 +G0 and Early G1 REACT:R-HSA-1538133 +G1 Phase REACT:R-HSA-69236 +G1/S DNA Damage Checkpoints REACT:R-HSA-69615 +G1/S-Specific Transcription REACT:R-HSA-69205 +G1/S Transition REACT:R-HSA-69206 +G2/M Checkpoints REACT:R-HSA-69481 +G2/M DNA damage checkpoint REACT:R-HSA-69473 +G2/M DNA replication checkpoint REACT:R-HSA-69478 +G2/M Transition REACT:R-HSA-69275 +G2 Phase REACT:R-HSA-68911 +GAB1 signalosome REACT:R-HSA-180292 +GABA A receptor activation REACT:R-HSA-977441 +GABA A (rho) receptor activation REACT:R-HSA-977442 +GABA biosynthesis, eukaryotes, putrescine => GABA KEGG:hsa_M00135 +GABA B receptor activation REACT:R-HSA-977444 +GABAergic synapse KEGG:hsa04727 +GABA (gamma-Aminobutyrate) shunt KEGG:hsa_M00027 +GABA receptor activation REACT:R-HSA-977443 +GABA synthesis REACT:R-HSA-888568 +GABA synthesis, release, reuptake and degradation REACT:R-HSA-888590 +Galactose catabolism REACT:R-HSA-70370 +Galactose degradation, Leloir pathway, galactose => alpha-D-glucose-1P KEGG:hsa_M00632 +Galactose metabolism KEGG:hsa00052 +G alpha (12/13) signalling events REACT:R-HSA-416482 +G alpha (i) signalling events REACT:R-HSA-418594 +G alpha (q) signalling events REACT:R-HSA-416476 +G alpha (s) signalling events REACT:R-HSA-418555 +G alpha (z) signalling events REACT:R-HSA-418597 +Gamma carboxylation, hypusine formation and arylsulfatase activation REACT:R-HSA-163841 +Gamma-carboxylation of protein precursors REACT:R-HSA-159740 +Gamma-carboxylation, transport, and amino-terminal cleavage of proteins REACT:R-HSA-159854 +Gap-filling DNA repair synthesis and ligation in GG-NER REACT:R-HSA-5696397 +Gap-filling DNA repair synthesis and ligation in TC-NER REACT:R-HSA-6782210 +Gap junction KEGG:hsa04540 +Gap junction assembly REACT:R-HSA-190861 +Gap junction degradation REACT:R-HSA-190873 +Gap junction trafficking REACT:R-HSA-190828 +Gap junction trafficking and regulation REACT:R-HSA-157858 +Gastric acid secretion KEGG:hsa04971 +Gastrin-CREB signalling pathway via PKC and MAPK REACT:R-HSA-881907 +G beta:gamma signalling through PI3Kgamma REACT:R-HSA-392451 +G beta:gamma signalling through PLC beta REACT:R-HSA-418217 +GDP-fucose biosynthesis REACT:R-HSA-6787639 +Gene Expression REACT:R-HSA-74160 +Generation of second messenger molecules REACT:R-HSA-202433 +Generic Transcription Pathway REACT:R-HSA-212436 +Gene Silencing by RNA REACT:R-HSA-211000 +GINS complex KEGG:hsa_M00286 +GLI3 is processed to GLI3R by the proteasome REACT:R-HSA-5610785 +Glioma KEGG:hsa05214 +GLI proteins bind promoters of Hh responsive genes to promote transcription REACT:R-HSA-5635851 +Global Genome Nucleotide Excision Repair (GG-NER) REACT:R-HSA-5696399 +Glucagon-like Peptide-1 (GLP1) regulates insulin secretion REACT:R-HSA-381676 +Glucagon signaling in metabolic regulation REACT:R-HSA-163359 +Glucagon signaling pathway KEGG:hsa04922 +Glucagon-type ligand receptors REACT:R-HSA-420092 +Glucocorticoid biosynthesis REACT:R-HSA-194002 +Gluconeogenesis REACT:R-HSA-70263 +Gluconeogenesis, oxaloacetate => fructose-6P KEGG:hsa_M00003 +Glucose metabolism REACT:R-HSA-70326 +Glucose transport REACT:R-HSA-70153 +Glucuronate pathway (uronate pathway) KEGG:hsa_M00014 +Glucuronidation REACT:R-HSA-156588 +Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity REACT:R-HSA-399721 +Glutamate Neurotransmitter Release Cycle REACT:R-HSA-210500 +Glutamatergic synapse KEGG:hsa04724 +Glutathione biosynthesis, glutamate => glutathione KEGG:hsa_M00118 +Glutathione conjugation REACT:R-HSA-156590 +Glutathione metabolism KEGG:hsa00480 +Glutathione synthesis and recycling REACT:R-HSA-174403 +Glycerolipid metabolism KEGG:hsa00561 +Glycerophospholipid biosynthesis REACT:R-HSA-1483206 +Glycerophospholipid catabolism REACT:R-HSA-6814848 +Glycerophospholipid metabolism KEGG:hsa00564 +Glycine degradation REACT:R-HSA-6783984 +Glycine, serine and threonine metabolism KEGG:hsa00260 +Glycogen breakdown (glycogenolysis) REACT:R-HSA-70221 +Glycogen storage diseases REACT:R-HSA-3229121 +Glycogen storage disease type 0 (liver GYS2) REACT:R-HSA-3858516 +Glycogen storage disease type 0 (muscle GYS1) REACT:R-HSA-3828062 +Glycogen storage disease type Ia (G6PC) REACT:R-HSA-3274531 +Glycogen storage disease type Ib (SLC37A4) REACT:R-HSA-3229133 +Glycogen storage disease type II (GAA) REACT:R-HSA-5357609 +Glycogen storage disease type IV (GBE1) REACT:R-HSA-3878781 +Glycogen storage disease type XV (GYG1) REACT:R-HSA-3814836 +Glycogen synthesis REACT:R-HSA-3322077 +Glycolysis REACT:R-HSA-70171 +Glycolysis, core module involving three-carbon compounds KEGG:hsa_M00002 +Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate KEGG:hsa_M00001 +Glycolysis / Gluconeogenesis KEGG:hsa00010 +Glycoprotein hormones REACT:R-HSA-209822 +Glycosaminoglycan biosynthesis, chondroitin sulfate backbone KEGG:hsa_M00058 +Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate KEGG:hsa00532 +Glycosaminoglycan biosynthesis, heparan sulfate backbone KEGG:hsa_M00059 +Glycosaminoglycan biosynthesis - heparan sulfate / heparin KEGG:hsa00534 +Glycosaminoglycan biosynthesis - keratan sulfate KEGG:hsa00533 +Glycosaminoglycan biosynthesis, linkage tetrasaccharide KEGG:hsa_M00057 +Glycosaminoglycan degradation KEGG:hsa00531 +Glycosaminoglycan metabolism REACT:R-HSA-1630316 +Glycosphingolipid biosynthesis - ganglio series KEGG:hsa00604 +Glycosphingolipid biosynthesis, ganglio series, LacCer => GT3 KEGG:hsa_M00069 +Glycosphingolipid biosynthesis - globo and isoglobo series KEGG:hsa00603 +Glycosphingolipid biosynthesis, globo-series, LacCer => Gb4Cer KEGG:hsa_M00068 +Glycosphingolipid biosynthesis - lacto and neolacto series KEGG:hsa00601 +Glycosphingolipid biosynthesis, lacto-series, LacCer => Lc4Cer KEGG:hsa_M00070 +Glycosphingolipid biosynthesis, neolacto-series, LacCer => nLc4Cer KEGG:hsa_M00071 +Glycosphingolipid metabolism REACT:R-HSA-1660662 +Glycosylphosphatidylinositol (GPI)-anchor biosynthesis KEGG:hsa00563 +Glyoxylate and dicarboxylate metabolism KEGG:hsa00630 +Glyoxylate metabolism and glycine degradation REACT:R-HSA-389661 +GnRH signaling pathway KEGG:hsa04912 +Golgi Associated Vesicle Biogenesis REACT:R-HSA-432722 +Golgi Cisternae Pericentriolar Stack Reorganization REACT:R-HSA-162658 +Golgi-to-ER retrograde transport REACT:R-HSA-8856688 +GP1b-IX-V activation signalling REACT:R-HSA-430116 +GPCR downstream signaling REACT:R-HSA-388396 +GPCR ligand binding REACT:R-HSA-500792 +GPI-anchor biosynthesis, core oligosaccharide KEGG:hsa_M00065 +G-protein activation REACT:R-HSA-202040 +G-protein beta:gamma signalling REACT:R-HSA-397795 +G protein gated Potassium channels REACT:R-HSA-1296059 +G-protein mediated events REACT:R-HSA-112040 +GPVI-mediated activation cascade REACT:R-HSA-114604 +Graft-versus-host disease KEGG:hsa05332 +GRB2 events in EGFR signaling REACT:R-HSA-179812 +GRB2 events in ERBB2 signaling REACT:R-HSA-1963640 +GRB2:SOS provides linkage to MAPK signaling for Integrins REACT:R-HSA-354194 +GRB7 events in ERBB2 signaling REACT:R-HSA-1306955 +Growth hormone receptor signaling REACT:R-HSA-982772 +GTP hydrolysis and joining of the 60S ribosomal subunit REACT:R-HSA-72706 +Guanine ribonucleotide biosynthesis IMP => GDP,GTP KEGG:hsa_M00050 +H/ACA ribonucleoprotein complex KEGG:hsa_M00425 +HATs acetylate histones REACT:R-HSA-3214847 +HCN channels REACT:R-HSA-1296061 +HDACs deacetylate histones REACT:R-HSA-3214815 +HDL-mediated lipid transport REACT:R-HSA-194223 +HDMs demethylate histones REACT:R-HSA-3214842 +HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) REACT:R-HSA-5693567 +HDR through Homologous Recombination (HRR) REACT:R-HSA-5685942 +HDR through MMEJ (alt-NHEJ) REACT:R-HSA-5685939 +HDR through Single Strand Annealing (SSA) REACT:R-HSA-5685938 +Hedgehog ligand biogenesis REACT:R-HSA-5358346 +Hedgehog 'off' state REACT:R-HSA-5610787 +Hedgehog 'on' state REACT:R-HSA-5632684 +Hedgehog signaling KEGG:hsa_M00678 +Hedgehog signaling pathway KEGG:hsa04340 +Hematopoietic cell lineage KEGG:hsa04640 +Heme biosynthesis REACT:R-HSA-189451 +Heme degradation REACT:R-HSA-189483 +Hemostasis REACT:R-HSA-109582 +Heparan sulfate degradation KEGG:hsa_M00078 +Heparan sulfate/heparin (HS-GAG) metabolism REACT:R-HSA-1638091 +Hepatitis B KEGG:hsa05161 +Hepatitis C KEGG:hsa05160 +Hereditary fructose intolerance REACT:R-HSA-5657560 +Herpes simplex infection KEGG:hsa05168 +Hexose transport REACT:R-HSA-189200 +HHAT G278V abrogates palmitoylation of Hh-Np REACT:R-HSA-5658034 +Hh mutants abrogate ligand secretion REACT:R-HSA-5387390 +Hh mutants that don't undergo autocatalytic processing are degraded by ERAD REACT:R-HSA-5362768 +HIF-1 signaling pathway KEGG:hsa04066 +Highly calcium permeable nicotinic acetylcholine receptors REACT:R-HSA-629597 +Highly calcium permeable postsynaptic nicotinic acetylcholine receptors REACT:R-HSA-629594 +Highly sodium permeable acetylcholine nicotinic receptors REACT:R-HSA-629587 +Hippo signaling KEGG:hsa_M00683 +Hippo signaling pathway KEGG:hsa04390 +Hippo signaling pathway -multiple species KEGG:hsa04392 +Histamine receptors REACT:R-HSA-390650 +Histidine catabolism REACT:R-HSA-70921 +Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism REACT:R-HSA-6788656 +Histidine metabolism KEGG:hsa00340 +HIV elongation arrest and recovery REACT:R-HSA-167287 +HIV Infection REACT:R-HSA-162906 +HIV Life Cycle REACT:R-HSA-162587 +HIV Transcription Elongation REACT:R-HSA-167169 +HIV Transcription Initiation REACT:R-HSA-167161 +Holo-TFIIH complex KEGG:hsa_M00290 +Homologous DNA Pairing and Strand Exchange REACT:R-HSA-5693579 +Homologous recombination KEGG:hsa03440 +Homology Directed Repair REACT:R-HSA-5693538 +Hormone ligand-binding receptors REACT:R-HSA-375281 +Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis REACT:R-HSA-163560 +Host Interactions of HIV factors REACT:R-HSA-162909 +Host Interactions with Influenza Factors REACT:R-HSA-168253 +HRD1/SEL1 ERAD complex KEGG:hsa_M00403 +HSF1 activation REACT:R-HSA-3371511 +HSF1-dependent transactivation REACT:R-HSA-3371571 +HS-GAG biosynthesis REACT:R-HSA-2022928 +HS-GAG degradation REACT:R-HSA-2024096 +HTLV-I infection KEGG:hsa05166 +Huntington's disease KEGG:hsa05016 +HuR (ELAVL1) binds and stabilizes mRNA REACT:R-HSA-450520 +Hyaluronan biosynthesis and export REACT:R-HSA-2142850 +Hyaluronan metabolism REACT:R-HSA-2142845 +Hyaluronan uptake and degradation REACT:R-HSA-2160916 +Hydrolysis of LPC REACT:R-HSA-1483115 +Hydrolysis of LPE REACT:R-HSA-1483152 +Hydroxycarboxylic acid-binding receptors REACT:R-HSA-3296197 +Hypertrophic cardiomyopathy (HCM) KEGG:hsa05410 +Hypusine synthesis from eIF5A-lysine REACT:R-HSA-204626 +IGF1R signaling cascade REACT:R-HSA-2428924 +IkBA variant leads to EDA-ID REACT:R-HSA-5603029 +IKBKB deficiency causes SCID REACT:R-HSA-5602636 +IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) REACT:R-HSA-5603027 +IKK complex recruitment mediated by RIP1 REACT:R-HSA-937041 +IL-17 signaling pathway KEGG:hsa04657 +IL-6-type cytokine receptor ligand interactions REACT:R-HSA-6788467 +Immune System REACT:R-HSA-168256 +Immunoproteasome KEGG:hsa_M00337 +Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell REACT:R-HSA-198933 +Import of palmitoyl-CoA into the mitochondrial matrix REACT:R-HSA-200425 +Inactivation of APC/C via direct inhibition of the APC/C complex REACT:R-HSA-141430 +Inactivation of Cdc42 and Rac REACT:R-HSA-428543 +Inactivation, recovery and regulation of the phototransduction cascade REACT:R-HSA-2514859 +Incretin synthesis, secretion, and inactivation REACT:R-HSA-400508 +Infectious disease REACT:R-HSA-5663205 +Inflammasomes REACT:R-HSA-622312 +Inflammatory bowel disease (IBD) KEGG:hsa05321 +Inflammatory mediator regulation of TRP channels KEGG:hsa04750 +Influenza A KEGG:hsa05164 +Influenza Infection REACT:R-HSA-168254 +Influenza Life Cycle REACT:R-HSA-168255 +Influenza Viral RNA Transcription and Replication REACT:R-HSA-168273 +Influenza Virus Induced Apoptosis REACT:R-HSA-168277 +Inhibition of adenylate cyclase pathway REACT:R-HSA-997269 +Inhibition of Host mRNA Processing and RNA Silencing REACT:R-HSA-168315 +Inhibition of IFN-beta REACT:R-HSA-168888 +Inhibition of Interferon Synthesis REACT:R-HSA-168305 +Inhibition of PKR REACT:R-HSA-169131 +Inhibition of replication initiation of damaged DNA by RB1/E2F1 REACT:R-HSA-113501 +Inhibition of Signaling by Overexpressed EGFR REACT:R-HSA-5638303 +Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components REACT:R-HSA-141405 +Inhibition of TSC complex formation by PKB REACT:R-HSA-165181 +Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits REACT:R-HSA-997272 +Initial triggering of complement REACT:R-HSA-166663 +Initiation of Nuclear Envelope Reformation REACT:R-HSA-2995383 +InlA-mediated entry of Listeria monocytogenes into host cells REACT:R-HSA-8876493 +InlB-mediated entry of Listeria monocytogenes into host cell REACT:R-HSA-8875360 +Innate Immune System REACT:R-HSA-168249 +Inosine monophosphate biosynthesis, PRPP + glutamine => IMP KEGG:hsa_M00048 +Inositol phosphate metabolism KEGG:hsa00562 +Inositol phosphate metabolism REACT:R-HSA-1483249 +Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositol KEGG:hsa_M00131 +Inositol phosphate metabolism, Ins(1,3,4)P3 => phytate KEGG:hsa_M00132 +Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 KEGG:hsa_M00130 +Inositol transporters REACT:R-HSA-429593 +Insulin effects increased synthesis of Xylulose-5-Phosphate REACT:R-HSA-163754 +Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA REACT:R-HSA-428359 +Insulin processing REACT:R-HSA-264876 +Insulin receptor recycling REACT:R-HSA-77387 +Insulin receptor signalling cascade REACT:R-HSA-74751 +Insulin resistance KEGG:hsa04931 +Insulin secretion KEGG:hsa04911 +Insulin signaling pathway KEGG:hsa04910 +Integration of energy metabolism REACT:R-HSA-163685 +Integration of provirus REACT:R-HSA-162592 +Integration of viral DNA into host genomic DNA REACT:R-HSA-175567 +Integrin alphaIIb beta3 signaling REACT:R-HSA-354192 +Integrin cell surface interactions REACT:R-HSA-216083 +Interaction between L1 and Ankyrins REACT:R-HSA-445095 +Interaction between PHLDA1 and AURKA REACT:R-HSA-8854521 +Interactions of neurexins and neuroligins at synapses REACT:R-HSA-6794361 +Interactions of Rev with host cellular proteins REACT:R-HSA-177243 +Interactions of Tat with host cellular proteins REACT:R-HSA-176034 +Interactions of Vpr with host cellular proteins REACT:R-HSA-176033 +Interaction With Cumulus Cells REACT:R-HSA-2534343 +Interaction With The Zona Pellucida REACT:R-HSA-1300644 +Interconversion of 2-oxoglutarate and 2-hydroxyglutarate REACT:R-HSA-880009 +Interconversion of polyamines REACT:R-HSA-351200 +Interferon alpha/beta signaling REACT:R-HSA-909733 +Interferon gamma signaling REACT:R-HSA-877300 +Interferon Signaling REACT:R-HSA-913531 +Interleukin-10 signaling REACT:R-HSA-6783783 +Interleukin-12 signaling REACT:R-HSA-447115 +Interleukin-17 signaling REACT:R-HSA-448424 +Interleukin-19, 20, 22, 24 REACT:R-HSA-8854691 +Interleukin-1 processing REACT:R-HSA-448706 +Interleukin-1 signaling REACT:R-HSA-446652 +Interleukin-2 signaling REACT:R-HSA-451927 +Interleukin-3, 5 and GM-CSF signaling REACT:R-HSA-512988 +Interleukin-4 and 13 signaling REACT:R-HSA-6785807 +Interleukin-6 family signaling REACT:R-HSA-6783589 +Interleukin-6 signaling REACT:R-HSA-1059683 +Interleukin-7 signaling REACT:R-HSA-1266695 +Interleukin receptor SHC signaling REACT:R-HSA-912526 +Intestinal immune network for IgA production KEGG:hsa04672 +Intestinal infectious diseases REACT:R-HSA-8942233 +Intestinal saccharidase deficiencies REACT:R-HSA-5659898 +Intraflagellar transport REACT:R-HSA-5620924 +Intra-Golgi and retrograde Golgi-to-ER traffic REACT:R-HSA-6811442 +Intra-Golgi traffic REACT:R-HSA-6811438 +Intrinsic Pathway for Apoptosis REACT:R-HSA-109606 +Intrinsic Pathway of Fibrin Clot Formation REACT:R-HSA-140837 +Inwardly rectifying K+ channels REACT:R-HSA-1296065 +Ion channel transport REACT:R-HSA-983712 +Ion homeostasis REACT:R-HSA-5578775 +Ion influx/efflux at host-pathogen interface REACT:R-HSA-6803544 +Ionotropic activity of Kainate Receptors REACT:R-HSA-451306 +Ion transport by P-type ATPases REACT:R-HSA-936837 +IP3 and IP4 transport between cytosol and nucleus REACT:R-HSA-1855196 +IP6 and IP7 transport between cytosol and nucleus REACT:R-HSA-1855229 +IPs transport between cytosol and ER lumen REACT:R-HSA-1855184 +IPs transport between ER lumen and cytosol REACT:R-HSA-1855215 +IPs transport between ER lumen and nucleus REACT:R-HSA-1855156 +IPs transport between nucleus and cytosol REACT:R-HSA-1855170 +IPs transport between nucleus and ER lumen REACT:R-HSA-1855192 +IRAK1 recruits IKK complex REACT:R-HSA-937039 +IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation REACT:R-HSA-975144 +IRAK2 mediated activation of TAK1 complex REACT:R-HSA-937042 +IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation REACT:R-HSA-975163 +IRAK4 deficiency (TLR2/4) REACT:R-HSA-5603041 +IRAK4 deficiency (TLR5) REACT:R-HSA-5603037 +IRE1alpha activates chaperones REACT:R-HSA-381070 +IRF3 mediated activation of type 1 IFN REACT:R-HSA-1606341 +IRF3-mediated induction of type I IFN REACT:R-HSA-3270619 +Iron uptake and transport REACT:R-HSA-917937 +IRS activation REACT:R-HSA-74713 +IRS-mediated signalling REACT:R-HSA-112399 +IRS-related events triggered by IGF1R REACT:R-HSA-2428928 +ISG15 antiviral mechanism REACT:R-HSA-1169408 +JAK-STAT signaling KEGG:hsa_M00684 +Jak-STAT signaling pathway KEGG:hsa04630 +JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 REACT:R-HSA-450321 +Josephin domain DUBs REACT:R-HSA-5689877 +Keratan sulfate biosynthesis REACT:R-HSA-2022854 +Keratan sulfate degradation KEGG:hsa_M00079 +Keratan sulfate degradation REACT:R-HSA-2022857 +Keratan sulfate/keratin metabolism REACT:R-HSA-1638074 +Keratinization REACT:R-HSA-6805567 +Ketone body metabolism REACT:R-HSA-74182 +Kinesins REACT:R-HSA-983189 +KSRP (KHSRP) binds and destabilizes mRNA REACT:R-HSA-450604 +L13a-mediated translational silencing of Ceruloplasmin expression REACT:R-HSA-156827 +L1CAM interactions REACT:R-HSA-373760 +Lactose synthesis REACT:R-HSA-5653890 +Lactosylceramide biosynthesis KEGG:hsa_M00066 +Lagging Strand Synthesis REACT:R-HSA-69186 +Laminin interactions REACT:R-HSA-3000157 +Latent infection of Homo sapiens with Mycobacterium tuberculosis REACT:R-HSA-1222352 +Late Phase of HIV Life Cycle REACT:R-HSA-162599 +LDL-mediated lipid transport REACT:R-HSA-171052 +Leading Strand Synthesis REACT:R-HSA-69109 +Lectin pathway of complement activation REACT:R-HSA-166662 +Legionellosis KEGG:hsa05134 +Leishmaniasis KEGG:hsa05140 +Leucine degradation, leucine => acetoacetate + acetyl-CoA KEGG:hsa_M00036 +Leukocyte transendothelial migration KEGG:hsa04670 +Leukotriene receptors REACT:R-HSA-391906 +LGI-ADAM interactions REACT:R-HSA-5682910 +Ligand-dependent caspase activation REACT:R-HSA-140534 +Ligand-gated ion channel transport REACT:R-HSA-975298 +Ligand-independent caspase activation via DCC REACT:R-HSA-418889 +Ligand-receptor interactions REACT:R-HSA-5632681 +Linoleic acid (LA) metabolism REACT:R-HSA-2046105 +Linoleic acid metabolism KEGG:hsa00591 +Lipid digestion, mobilization, and transport REACT:R-HSA-73923 +Lipoic acid metabolism KEGG:hsa00785 +Lipoprotein metabolism REACT:R-HSA-174824 +Listeria monocytogenes entry into host cells REACT:R-HSA-8876384 +Localization of the PINCH-ILK-PARVIN complex to focal adhesions REACT:R-HSA-446343 +Longevity regulating pathway KEGG:hsa04211 +Longevity regulating pathway - multiple species KEGG:hsa04213 +Long-term depression KEGG:hsa04730 +Long-term potentiation KEGG:hsa04720 +Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling REACT:R-HSA-2644607 +Loss of Function of SMAD2/3 in Cancer REACT:R-HSA-3304349 +Loss of Function of SMAD4 in Cancer REACT:R-HSA-3304347 +Loss of Function of TGFBR1 in Cancer REACT:R-HSA-3656534 +Loss of Function of TGFBR2 in Cancer REACT:R-HSA-3642278 +Loss of Nlp from mitotic centrosomes REACT:R-HSA-380259 +Loss of proteins required for interphase microtubule organization from the centrosome REACT:R-HSA-380284 +LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production REACT:R-HSA-3134973 +Lsm 1-7 complex KEGG:hsa_M00397 +Lsm 2-8 complex KEGG:hsa_M00396 +Lysine biosynthesis KEGG:hsa00300 +Lysine catabolism REACT:R-HSA-71064 +Lysine degradation KEGG:hsa00310 +Lysine degradation, lysine => saccharopine => acetoacetyl-CoA KEGG:hsa_M00032 +Lysosomal glycogen catabolism REACT:R-HSA-5357572 +Lysosomal oligosaccharide catabolism REACT:R-HSA-8853383 +Lysosome KEGG:hsa04142 +Lysosome Vesicle Biogenesis REACT:R-HSA-432720 +Lysosphingolipid and LPA receptors REACT:R-HSA-419408 +Macroautophagy REACT:R-HSA-1632852 +Major pathway of rRNA processing in the nucleolus and cytosol REACT:R-HSA-6791226 +Malaria KEGG:hsa05144 +Malonate semialdehyde pathway, propanoyl-CoA => acetyl-CoA KEGG:hsa_M00013 +Mannose type O-glycan biosynthesis KEGG:hsa00515 +MAP2K and MAPK activation REACT:R-HSA-5674135 +MAP3K8 (TPL2)-dependent MAPK1/3 activation REACT:R-HSA-5684264 +MAPK1 (ERK2) activation REACT:R-HSA-112411 +MAPK1/MAPK3 signaling REACT:R-HSA-5684996 +MAPK3 (ERK1) activation REACT:R-HSA-110056 +MAPK6/MAPK4 signaling REACT:R-HSA-5687128 +MAPK (ERK1/2) signaling KEGG:hsa_M00687 +MAPK (ERK5) signaling KEGG:hsa_M00690 +MAPK family signaling cascades REACT:R-HSA-5683057 +MAP kinase activation in TLR cascade REACT:R-HSA-450294 +MAPK (JNK) signaling KEGG:hsa_M00688 +MAPK (p38) signaling KEGG:hsa_M00689 +MAPK signaling pathway KEGG:hsa04010 +MAPK targets/ Nuclear events mediated by MAP kinases REACT:R-HSA-450282 +MASTL Facilitates Mitotic Progression REACT:R-HSA-2465910 +Maturity onset diabetes of the young KEGG:hsa04950 +MCM complex KEGG:hsa_M00285 +Measles KEGG:hsa05162 +Meiosis REACT:R-HSA-1500620 +Meiotic recombination REACT:R-HSA-912446 +Meiotic synapsis REACT:R-HSA-1221632 +Melanin biosynthesis REACT:R-HSA-5662702 +Melanogenesis KEGG:hsa04916 +Melanoma KEGG:hsa05218 +Melatonin biosynthesis, tryptophan => serotonin => melatonin KEGG:hsa_M00037 +Membrane binding and targetting of GAG proteins REACT:R-HSA-174490 +Membrane Trafficking REACT:R-HSA-199991 +Metabolic disorders of biological oxidation enzymes REACT:R-HSA-5579029 +Metabolic pathways KEGG:hsa01100 +Metabolism REACT:R-HSA-1430728 +Metabolism of amino acids and derivatives REACT:R-HSA-71291 +Metabolism of Angiotensinogen to Angiotensins REACT:R-HSA-2022377 +Metabolism of carbohydrates REACT:R-HSA-71387 +Metabolism of fat-soluble vitamins REACT:R-HSA-6806667 +Metabolism of folate and pterines REACT:R-HSA-196757 +Metabolism of ingested H2SeO4 and H2SeO3 into H2Se REACT:R-HSA-2408550 +Metabolism of ingested MeSeO2H into MeSeH REACT:R-HSA-5263617 +Metabolism of ingested SeMet, Sec, MeSec into H2Se REACT:R-HSA-2408508 +Metabolism of lipids and lipoproteins REACT:R-HSA-556833 +Metabolism of nitric oxide REACT:R-HSA-202131 +Metabolism of non-coding RNA REACT:R-HSA-194441 +Metabolism of nucleotides REACT:R-HSA-15869 +Metabolism of polyamines REACT:R-HSA-351202 +Metabolism of porphyrins REACT:R-HSA-189445 +Metabolism of proteins REACT:R-HSA-392499 +Metabolism of serotonin REACT:R-HSA-380612 +Metabolism of steroid hormones REACT:R-HSA-196071 +Metabolism of vitamin K REACT:R-HSA-6806664 +Metabolism of vitamins and cofactors REACT:R-HSA-196854 +Metabolism of water-soluble vitamins and cofactors REACT:R-HSA-196849 +Metabolism of xenobiotics by cytochrome P450 KEGG:hsa00980 +MET activates PI3K/AKT signaling REACT:R-HSA-8851907 +MET activates PTK2 signaling REACT:R-HSA-8874081 +MET activates PTPN11 REACT:R-HSA-8865999 +MET activates RAP1 and RAC1 REACT:R-HSA-8875555 +MET activates RAS signaling REACT:R-HSA-8851805 +MET activates STAT3 REACT:R-HSA-8875791 +Metal ion SLC transporters REACT:R-HSA-425410 +Metalloprotease DUBs REACT:R-HSA-5689901 +Metallothioneins bind metals REACT:R-HSA-5661231 +Metal sequestration by antimicrobial proteins REACT:R-HSA-6799990 +Methionine degradation KEGG:hsa_M00035 +Methionine salvage pathway KEGG:hsa_M00034 +Methionine salvage pathway REACT:R-HSA-1237112 +Methylation REACT:R-HSA-156581 +Methylation of MeSeH for excretion REACT:R-HSA-2408552 +MET interacts with TNS proteins REACT:R-HSA-8875513 +MET promotes cell motility REACT:R-HSA-8875878 +MET Receptor Activation REACT:R-HSA-6806942 +MET receptor recycling REACT:R-HSA-8875656 +M/G1 Transition REACT:R-HSA-68874 +MGMT-mediated DNA damage reversal REACT:R-HSA-5657655 +MHC class II antigen presentation REACT:R-HSA-2132295 +MicroRNA (miRNA) biogenesis REACT:R-HSA-203927 +MicroRNAs in cancer KEGG:hsa05206 +Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane REACT:R-HSA-190840 +Mineral absorption KEGG:hsa04978 +Mineralocorticoid biosynthesis REACT:R-HSA-193993 +Minus-strand DNA synthesis REACT:R-HSA-164516 +Miscellaneous digestion events REACT:R-HSA-8935690 +Miscellaneous substrates REACT:R-HSA-211958 +Miscellaneous transport and binding events REACT:R-HSA-5223345 +Mismatch repair KEGG:hsa03430 +Mismatch Repair REACT:R-HSA-5358508 +Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) REACT:R-HSA-5358606 +Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) REACT:R-HSA-5358565 +Misspliced GSK3beta mutants stabilize beta-catenin REACT:R-HSA-5339716 +Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling REACT:R-HSA-5339717 +Mitochondrial ABC transporters REACT:R-HSA-1369007 +Mitochondrial biogenesis REACT:R-HSA-1592230 +Mitochondrial Fatty Acid Beta-Oxidation REACT:R-HSA-77289 +mitochondrial fatty acid beta-oxidation of saturated fatty acids REACT:R-HSA-77286 +mitochondrial fatty acid beta-oxidation of unsaturated fatty acids REACT:R-HSA-77288 +Mitochondrial iron-sulfur cluster biogenesis REACT:R-HSA-1362409 +Mitochondrial protein import REACT:R-HSA-1268020 +Mitochondrial transcription initiation REACT:R-HSA-163282 +Mitochondrial transcription termination REACT:R-HSA-163316 +Mitochondrial translation REACT:R-HSA-5368287 +Mitochondrial translation elongation REACT:R-HSA-5389840 +Mitochondrial translation initiation REACT:R-HSA-5368286 +Mitochondrial translation termination REACT:R-HSA-5419276 +Mitochondrial tRNA aminoacylation REACT:R-HSA-379726 +Mitochondrial Uncoupling Proteins REACT:R-HSA-166187 +Mitophagy REACT:R-HSA-5205647 +Mitophagy - animal KEGG:hsa04137 +Mitotic Anaphase REACT:R-HSA-68882 +Mitotic G1-G1/S phases REACT:R-HSA-453279 +Mitotic G2-G2/M phases REACT:R-HSA-453274 +Mitotic Metaphase/Anaphase Transition REACT:R-HSA-68881 +Mitotic Metaphase and Anaphase REACT:R-HSA-2555396 +Mitotic Prometaphase REACT:R-HSA-68877 +Mitotic Prophase REACT:R-HSA-68875 +Mitotic Spindle Checkpoint REACT:R-HSA-69618 +Mitotic Telophase/Cytokinesis REACT:R-HSA-68884 +Molecules associated with elastic fibres REACT:R-HSA-2129379 +Molybdenum cofactor biosynthesis REACT:R-HSA-947581 +Morphine addiction KEGG:hsa05032 +M Phase REACT:R-HSA-68886 +MPS I - Hurler syndrome REACT:R-HSA-2206302 +MPS II - Hunter syndrome REACT:R-HSA-2206296 +MPS IIIA - Sanfilippo syndrome A REACT:R-HSA-2206307 +MPS IIIB - Sanfilippo syndrome B REACT:R-HSA-2206282 +MPS IIIC - Sanfilippo syndrome C REACT:R-HSA-2206291 +MPS IIID - Sanfilippo syndrome D REACT:R-HSA-2206305 +MPS IV - Morquio syndrome A REACT:R-HSA-2206290 +MPS IV - Morquio syndrome B REACT:R-HSA-2206308 +MPS IX - Natowicz syndrome REACT:R-HSA-2206280 +MPS VII - Sly syndrome REACT:R-HSA-2206292 +MPS VI - Maroteaux-Lamy syndrome REACT:R-HSA-2206285 +mRNA 3'-end processing REACT:R-HSA-72187 +mRNA Capping REACT:R-HSA-72086 +mRNA decay by 3' to 5' exoribonuclease REACT:R-HSA-429958 +mRNA decay by 5' to 3' exoribonuclease REACT:R-HSA-430039 +mRNA Editing REACT:R-HSA-75072 +mRNA Editing: A to I Conversion REACT:R-HSA-75064 +mRNA Editing: C to U Conversion REACT:R-HSA-72200 +mRNA Splicing REACT:R-HSA-72172 +mRNA Splicing - Major Pathway REACT:R-HSA-72163 +mRNA Splicing - Minor Pathway REACT:R-HSA-72165 +mRNA surveillance pathway KEGG:hsa03015 +MRN complex KEGG:hsa_M00291 +Mtb iron assimilation by chelation REACT:R-HSA-1222449 +mTORC1-mediated signalling REACT:R-HSA-166208 +mTOR signaling pathway KEGG:hsa04150 +mTOR signalling REACT:R-HSA-165159 +Mucin type O-glycan biosynthesis KEGG:hsa00512 +Mucopolysaccharidoses REACT:R-HSA-2206281 +Multifunctional anion exchangers REACT:R-HSA-427601 +Muscarinic acetylcholine receptors REACT:R-HSA-390648 +Muscle contraction REACT:R-HSA-397014 +MyD88 cascade initiated on plasma membrane REACT:R-HSA-975871 +MyD88 deficiency (TLR2/4) REACT:R-HSA-5602498 +MyD88 deficiency (TLR5) REACT:R-HSA-5602680 +MyD88 dependent cascade initiated on endosome REACT:R-HSA-975155 +MyD88-independent TLR3/TLR4 cascade REACT:R-HSA-166166 +MyD88:Mal cascade initiated on plasma membrane REACT:R-HSA-166058 +Myoclonic epilepsy of Lafora REACT:R-HSA-3785653 +Myogenesis REACT:R-HSA-525793 +Na+/Cl- dependent neurotransmitter transporters REACT:R-HSA-442660 +NADE modulates death signalling REACT:R-HSA-205025 +Na+-dependent glucose transporters REACT:R-HSA-428808 +NADH dehydrogenase (ubiquinone) 1 alpha subcomplex KEGG:hsa_M00146 +NADH dehydrogenase (ubiquinone) 1 beta subcomplex KEGG:hsa_M00147 +NADH dehydrogenase (ubiquinone) Fe-S protein/flavoprotein complex, mitochondria KEGG:hsa_M00143 +NADH:ubiquinone oxidoreductase, mitochondria KEGG:hsa_M00142 +NADPH regeneration REACT:R-HSA-389542 +Natural killer cell mediated cytotoxicity KEGG:hsa04650 +NCAM1 interactions REACT:R-HSA-419037 +NCAM signaling for neurite out-growth REACT:R-HSA-375165 +Nectin/Necl trans heterodimerization REACT:R-HSA-420597 +Nef and signal transduction REACT:R-HSA-164944 +Nef Mediated CD4 Down-regulation REACT:R-HSA-167590 +Nef Mediated CD8 Down-regulation REACT:R-HSA-182218 +Nef mediated downregulation of CD28 cell surface expression REACT:R-HSA-164939 +Nef mediated downregulation of MHC class I complex cell surface expression REACT:R-HSA-164940 +Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters REACT:R-HSA-164938 +Negative epigenetic regulation of rRNA expression REACT:R-HSA-5250941 +Negative feedback regulation of MAPK pathway REACT:R-HSA-5674499 +Negative regulation of activity of TFAP2 (AP-2) family transcription factors REACT:R-HSA-8866904 +Negative regulation of FGFR1 signaling REACT:R-HSA-5654726 +Negative regulation of FGFR2 signaling REACT:R-HSA-5654727 +Negative regulation of FGFR3 signaling REACT:R-HSA-5654732 +Negative regulation of FGFR4 signaling REACT:R-HSA-5654733 +Negative regulation of MAPK pathway REACT:R-HSA-5675221 +Negative regulation of MET activity REACT:R-HSA-6807004 +Negative regulation of TCF-dependent signaling by DVL-interacting proteins REACT:R-HSA-5368598 +Negative regulation of TCF-dependent signaling by WNT ligand antagonists REACT:R-HSA-3772470 +Negative regulation of the PI3K/AKT network REACT:R-HSA-199418 +Negative regulators of RIG-I/MDA5 signaling REACT:R-HSA-936440 +Neomycin, kanamycin and gentamicin biosynthesis KEGG:hsa00524 +Nephrin interactions REACT:R-HSA-373753 +NEP/NS2 Interacts with the Cellular Export Machinery REACT:R-HSA-168333 +Netrin-1 signaling REACT:R-HSA-373752 +Netrin mediated repulsion signals REACT:R-HSA-418886 +Neuroactive ligand-receptor interaction KEGG:hsa04080 +Neurodegenerative Diseases REACT:R-HSA-8863678 +Neurofascin interactions REACT:R-HSA-447043 +Neuronal System REACT:R-HSA-112316 +Neurophilin interactions with VEGF and VEGFR REACT:R-HSA-194306 +Neurotoxicity of clostridium toxins REACT:R-HSA-168799 +Neurotransmitter Clearance In The Synaptic Cleft REACT:R-HSA-112311 +Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell REACT:R-HSA-112314 +Neurotransmitter Release Cycle REACT:R-HSA-112310 +Neurotransmitter uptake and Metabolism In Glial Cells REACT:R-HSA-112313 +Neurotrophin signaling pathway KEGG:hsa04722 +Neutrophil degranulation REACT:R-HSA-6798695 +NFG and proNGF binds to p75NTR REACT:R-HSA-205017 +NF-kappa B signaling pathway KEGG:hsa04064 +NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 REACT:R-HSA-933543 +NF-kB is activated and signals survival REACT:R-HSA-209560 +NGF-independant TRKA activation REACT:R-HSA-187024 +NGF processing REACT:R-HSA-167060 +NGF signalling via TRKA from the plasma membrane REACT:R-HSA-187037 +N-Glycan antennae elongation REACT:R-HSA-975577 +N-glycan antennae elongation in the medial/trans-Golgi REACT:R-HSA-975576 +N-Glycan biosynthesis KEGG:hsa00510 +N-glycan biosynthesis, complex type KEGG:hsa_M00075 +N-glycan precursor biosynthesis KEGG:hsa_M00055 +N-glycan precursor trimming KEGG:hsa_M00073 +N-glycan trimming and elongation in the cis-Golgi REACT:R-HSA-964739 +N-glycan trimming in the ER and Calnexin/Calreticulin cycle REACT:R-HSA-532668 +N-glycosylation by oligosaccharyltransferase KEGG:hsa_M00072 +Nicotinamide salvaging REACT:R-HSA-197264 +Nicotinate and nicotinamide metabolism KEGG:hsa00760 +Nicotinate metabolism REACT:R-HSA-196807 +Nicotine addiction KEGG:hsa05033 +NIK-->noncanonical NF-kB signaling REACT:R-HSA-5676590 +Nitric oxide stimulates guanylate cyclase REACT:R-HSA-392154 +Nitrogen metabolism KEGG:hsa00910 +NOD1/2 Signaling Pathway REACT:R-HSA-168638 +NOD-like receptor signaling pathway KEGG:hsa04621 +Non-alcoholic fatty liver disease (NAFLD) KEGG:hsa04932 +Non-homologous end-joining KEGG:hsa03450 +Nonhomologous End-Joining (NHEJ) REACT:R-HSA-5693571 +Non-integrin membrane-ECM interactions REACT:R-HSA-3000171 +Nonsense-Mediated Decay (NMD) REACT:R-HSA-927802 +Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) REACT:R-HSA-975957 +Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) REACT:R-HSA-975956 +Non-small cell lung cancer KEGG:hsa05223 +NoRC negatively regulates rRNA expression REACT:R-HSA-427413 +Norepinephrine Neurotransmitter Release Cycle REACT:R-HSA-181430 +NOSIP mediated eNOS trafficking REACT:R-HSA-203754 +NOSTRIN mediated eNOS trafficking REACT:R-HSA-203641 +NOTCH1 Intracellular Domain Regulates Transcription REACT:R-HSA-2122947 +NOTCH2 Activation and Transmission of Signal to the Nucleus REACT:R-HSA-2979096 +NOTCH2 intracellular domain regulates transcription REACT:R-HSA-2197563 +Notch-HLH transcription pathway REACT:R-HSA-350054 +Notch signaling KEGG:hsa_M00682 +Notch signaling pathway KEGG:hsa04330 +NR1D1 (REV-ERBA) represses gene expression REACT:R-HSA-1368071 +NRAGE signals death through JNK REACT:R-HSA-193648 +NrCAM interactions REACT:R-HSA-447038 +NRIF signals cell death from the nucleus REACT:R-HSA-205043 +NS1 Mediated Effects on Host Pathways REACT:R-HSA-168276 +Nuclear Envelope Breakdown REACT:R-HSA-2980766 +Nuclear Envelope Reassembly REACT:R-HSA-2995410 +Nuclear Events (kinase and transcription factor activation) REACT:R-HSA-198725 +Nuclear import of Rev protein REACT:R-HSA-180746 +Nuclear pore complex KEGG:hsa_M00427 +Nuclear Pore Complex (NPC) Disassembly REACT:R-HSA-3301854 +Nuclear Receptor transcription pathway REACT:R-HSA-383280 +Nuclear signaling by ERBB4 REACT:R-HSA-1251985 +Nucleosome assembly REACT:R-HSA-774815 +Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways REACT:R-HSA-168643 +Nucleotide excision repair KEGG:hsa03420 +Nucleotide Excision Repair REACT:R-HSA-5696398 +Nucleotide-like (purinergic) receptors REACT:R-HSA-418038 +Nucleotide sugar biosynthesis, eukaryotes KEGG:hsa_M00361 +Nucleotide sugar biosynthesis, galactose => UDP-galactose KEGG:hsa_M00554 +Nucleotide sugar biosynthesis, glucose => UDP-glucose KEGG:hsa_M00549 +O2/CO2 exchange in erythrocytes REACT:R-HSA-1480926 +O-glycan biosynthesis, mucin type core KEGG:hsa_M00056 +O-glycosylation of TSR domain-containing proteins REACT:R-HSA-5173214 +Olfactory Signaling Pathway REACT:R-HSA-381753 +Olfactory transduction KEGG:hsa04740 +Oligomerization of connexins into connexons REACT:R-HSA-190704 +O-linked glycosylation REACT:R-HSA-5173105 +O-linked glycosylation of mucins REACT:R-HSA-913709 +Oncogene Induced Senescence REACT:R-HSA-2559585 +Oncogenic MAPK signaling REACT:R-HSA-6802957 +One carbon pool by folate KEGG:hsa00670 +Oocyte meiosis KEGG:hsa04114 +Opioid Signalling REACT:R-HSA-111885 +Opsins REACT:R-HSA-419771 +Orc1 removal from chromatin REACT:R-HSA-68949 +Orexin and neuropeptides FF and QRFP bind to their respective receptors REACT:R-HSA-389397 +Organelle biogenesis and maintenance REACT:R-HSA-1852241 +Organic anion transport REACT:R-HSA-561048 +Organic anion transporters REACT:R-HSA-428643 +Organic cation/anion/zwitterion transport REACT:R-HSA-549132 +Organic cation transport REACT:R-HSA-549127 +Origin recognition complex KEGG:hsa_M00284 +Osteoclast differentiation KEGG:hsa04380 +Other glycan degradation KEGG:hsa00511 +Other semaphorin interactions REACT:R-HSA-416700 +Other types of O-glycan biosynthesis KEGG:hsa00514 +Ovarian steroidogenesis KEGG:hsa04913 +Ovarian tumor domain proteases REACT:R-HSA-5689896 +Oxidative phosphorylation KEGG:hsa00190 +Oxidative Stress Induced Senescence REACT:R-HSA-2559580 +Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha REACT:R-HSA-1234162 +Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha REACT:R-HSA-1234176 +Oxytocin signaling pathway KEGG:hsa04921 +p130Cas linkage to MAPK signaling for integrins REACT:R-HSA-372708 +P2Y receptors REACT:R-HSA-417957 +p38MAPK events REACT:R-HSA-171007 +p53-Dependent G1 DNA Damage Response REACT:R-HSA-69563 +p53-Dependent G1/S DNA damage checkpoint REACT:R-HSA-69580 +p53-Independent DNA Damage Response REACT:R-HSA-69610 +p53-Independent G1/S DNA damage checkpoint REACT:R-HSA-69613 +p53 signaling pathway KEGG:hsa04115 +p75NTR negatively regulates cell cycle via SC1 REACT:R-HSA-193670 +p75 NTR receptor-mediated signalling REACT:R-HSA-193704 +p75NTR recruits signalling complexes REACT:R-HSA-209543 +p75NTR regulates axonogenesis REACT:R-HSA-193697 +p75NTR signals via NF-kB REACT:R-HSA-193639 +p97-Ufd1-Npl4 complex KEGG:hsa_M00400 +Packaging of Eight RNA Segments REACT:R-HSA-168303 +Packaging Of Telomere Ends REACT:R-HSA-171306 +Pancreatic cancer KEGG:hsa05212 +Pancreatic secretion KEGG:hsa04972 +Pantothenate and CoA biosynthesis KEGG:hsa00770 +PAOs oxidise polyamines to amines REACT:R-HSA-141334 +Paradoxical activation of RAF signaling by kinase inactive BRAF REACT:R-HSA-6802955 +Parkinson's disease KEGG:hsa05012 +Passive transport by Aquaporins REACT:R-HSA-432047 +Pathogenic Escherichia coli infection KEGG:hsa05130 +Pathways in cancer KEGG:hsa05200 +Pausing and recovery of HIV elongation REACT:R-HSA-167290 +Pausing and recovery of Tat-mediated HIV elongation REACT:R-HSA-167238 +PCNA-Dependent Long Patch Base Excision Repair REACT:R-HSA-5651801 +PCP/CE pathway REACT:R-HSA-4086400 +PD-1 signaling REACT:R-HSA-389948 +PDE3B signalling REACT:R-HSA-165160 +PECAM1 interactions REACT:R-HSA-210990 +Pentose and glucuronate interconversions KEGG:hsa00040 +Pentose phosphate pathway KEGG:hsa00030 +Pentose phosphate pathway disease REACT:R-HSA-6791465 +Pentose phosphate pathway (hexose monophosphate shunt) REACT:R-HSA-71336 +Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P KEGG:hsa_M00007 +Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P KEGG:hsa_M00006 +Pentose phosphate pathway (Pentose phosphate cycle) KEGG:hsa_M00004 +Peptide chain elongation REACT:R-HSA-156902 +Peptide hormone biosynthesis REACT:R-HSA-209952 +Peptide hormone metabolism REACT:R-HSA-2980736 +Peptide ligand-binding receptors REACT:R-HSA-375276 +PERK regulates gene expression REACT:R-HSA-381042 +Peroxisomal lipid metabolism REACT:R-HSA-390918 +Peroxisome KEGG:hsa04146 +Pertussis KEGG:hsa05133 +Phagosome KEGG:hsa04145 +Phase 0 - rapid depolarisation REACT:R-HSA-5576892 +Phase 1 - Functionalization of compounds REACT:R-HSA-211945 +Phase 1 - inactivation of fast Na+ channels REACT:R-HSA-5576894 +Phase 2 - plateau phase REACT:R-HSA-5576893 +Phase 3 - rapid repolarisation REACT:R-HSA-5576890 +Phase 4 - resting membrane potential REACT:R-HSA-5576886 +Phase II conjugation REACT:R-HSA-156580 +Phenylalanine and tyrosine catabolism REACT:R-HSA-71182 +Phenylalanine metabolism KEGG:hsa00360 +Phenylalanine, tyrosine and tryptophan biosynthesis KEGG:hsa00400 +Phenylketonuria REACT:R-HSA-2160456 +Phosphate bond hydrolysis by NTPDase proteins REACT:R-HSA-8850843 +Phosphate bond hydrolysis by NUDT proteins REACT:R-HSA-2393930 +Phosphatidylcholine (PC) biosynthesis, choline => PC KEGG:hsa_M00090 +Phosphatidylcholine (PC) biosynthesis, PE => PC KEGG:hsa_M00091 +Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE KEGG:hsa_M00092 +Phosphatidylinositol signaling system KEGG:hsa04070 +Phospholipase C-mediated cascade: FGFR1 REACT:R-HSA-5654219 +Phospholipase C-mediated cascade; FGFR2 REACT:R-HSA-5654221 +Phospholipase C-mediated cascade; FGFR3 REACT:R-HSA-5654227 +Phospholipase C-mediated cascade; FGFR4 REACT:R-HSA-5654228 +Phospholipase D signaling pathway KEGG:hsa04072 +Phospholipid metabolism REACT:R-HSA-1483257 +Phosphonate and phosphinate metabolism KEGG:hsa00440 +phospho-PLA2 pathway REACT:R-HSA-111995 +Phosphorylation of CD3 and TCR zeta chains REACT:R-HSA-202427 +Phosphorylation of Emi1 REACT:R-HSA-176417 +Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes REACT:R-HSA-69200 +Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes REACT:R-HSA-170145 +Phosphorylation of the APC/C REACT:R-HSA-176412 +phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex REACT:R-HSA-4839743 +Phototransduction KEGG:hsa04744 +Physiological factors REACT:R-HSA-5578768 +PI3K/AKT activation REACT:R-HSA-198203 +PI3K-Akt signaling KEGG:hsa_M00676 +PI3K/AKT Signaling in Cancer REACT:R-HSA-2219528 +PI3K-Akt signaling pathway KEGG:hsa04151 +PI3K Cascade REACT:R-HSA-109704 +PI-3K cascade:FGFR1 REACT:R-HSA-5654689 +PI-3K cascade:FGFR2 REACT:R-HSA-5654695 +PI-3K cascade:FGFR3 REACT:R-HSA-5654710 +PI-3K cascade:FGFR4 REACT:R-HSA-5654720 +PI3K events in ERBB2 signaling REACT:R-HSA-1963642 +PI3K events in ERBB4 signaling REACT:R-HSA-1250342 +PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling REACT:R-HSA-6811558 +PI5P Regulates TP53 Acetylation REACT:R-HSA-6811555 +PI and PC transport between ER and Golgi membranes REACT:R-HSA-1483196 +PI Metabolism REACT:R-HSA-1483255 +Pink/Parkin Mediated Mitophagy REACT:R-HSA-5205685 +PIP3 activates AKT signaling REACT:R-HSA-1257604 +PIPs transport between early and late endosome membranes REACT:R-HSA-1660502 +PIPs transport between early endosome and Golgi membranes REACT:R-HSA-1660537 +PIPs transport between Golgi and plasma membranes REACT:R-HSA-1660510 +PIPs transport between late endosome and Golgi membranes REACT:R-HSA-1660508 +PIPs transport between plasma and early endosome membranes REACT:R-HSA-1660524 +PIWI-interacting RNA (piRNA) biogenesis REACT:R-HSA-5601884 +PKA activation REACT:R-HSA-163615 +PKA activation in glucagon signalling REACT:R-HSA-164378 +PKA-mediated phosphorylation of CREB REACT:R-HSA-111931 +PKA-mediated phosphorylation of key metabolic factors REACT:R-HSA-163358 +PKB-mediated events REACT:R-HSA-109703 +PKMTs methylate histone lysines REACT:R-HSA-3214841 +Plasmalogen biosynthesis REACT:R-HSA-75896 +Platelet activation KEGG:hsa04611 +Platelet activation, signaling and aggregation REACT:R-HSA-76002 +Platelet Adhesion to exposed collagen REACT:R-HSA-75892 +Platelet Aggregation (Plug Formation) REACT:R-HSA-76009 +Platelet calcium homeostasis REACT:R-HSA-418360 +Platelet degranulation REACT:R-HSA-114608 +Platelet homeostasis REACT:R-HSA-418346 +Platelet sensitization by LDL REACT:R-HSA-432142 +Platinum drug resistance KEGG:hsa01524 +PLC beta mediated events REACT:R-HSA-112043 +PLCG1 events in ERBB2 signaling REACT:R-HSA-1251932 +PLC-gamma1 signalling REACT:R-HSA-167021 +Plus-strand DNA synthesis REACT:R-HSA-164525 +POLB-Dependent Long Patch Base Excision Repair REACT:R-HSA-110362 +Polo-like kinase mediated events REACT:R-HSA-156711 +Polyamine biosynthesis, arginine => agmatine => putrescine => spermidine KEGG:hsa_M00133 +Polyamine biosynthesis, arginine => ornithine => putrescine KEGG:hsa_M00134 +Polymerase switching REACT:R-HSA-69091 +Polymerase switching on the C-strand of the telomere REACT:R-HSA-174411 +Porphyrin and chlorophyll metabolism KEGG:hsa00860 +Positive epigenetic regulation of rRNA expression REACT:R-HSA-5250913 +Post-chaperonin tubulin folding pathway REACT:R-HSA-389977 +Post NMDA receptor activation events REACT:R-HSA-438064 +Postsynaptic nicotinic acetylcholine receptors REACT:R-HSA-622327 +Post-transcriptional silencing by small RNAs REACT:R-HSA-426496 +Post-translational modification: synthesis of GPI-anchored proteins REACT:R-HSA-163125 +Post-translational protein modification REACT:R-HSA-597592 +Potassium Channels REACT:R-HSA-1296071 +Potassium transport channels REACT:R-HSA-1296067 +POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation REACT:R-HSA-2892247 +POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation REACT:R-HSA-2892245 +PP2A-mediated dephosphorylation of key metabolic factors REACT:R-HSA-163767 +PPARA activates gene expression REACT:R-HSA-1989781 +PPAR signaling pathway KEGG:hsa03320 +PRC2 methylates histones and DNA REACT:R-HSA-212300 +Prefoldin mediated transfer of substrate to CCT/TriC REACT:R-HSA-389957 +Pregnenolone biosynthesis REACT:R-HSA-196108 +Pre-NOTCH Expression and Processing REACT:R-HSA-1912422 +Pre-NOTCH Processing in Golgi REACT:R-HSA-1912420 +Pre-NOTCH Processing in the Endoplasmic Reticulum REACT:R-HSA-1912399 +Pre-NOTCH Transcription and Translation REACT:R-HSA-1912408 +Presynaptic function of Kainate receptors REACT:R-HSA-500657 +Presynaptic nicotinic acetylcholine receptors REACT:R-HSA-622323 +Presynaptic phase of homologous DNA pairing and strand exchange REACT:R-HSA-5693616 +Primary bile acid biosynthesis KEGG:hsa00120 +Primary immunodeficiency KEGG:hsa05340 +Prion diseases KEGG:hsa05020 +Processing and activation of SUMO REACT:R-HSA-3215018 +Processing of Capped Intron-Containing Pre-mRNA REACT:R-HSA-72203 +Processing of Capped Intronless Pre-mRNA REACT:R-HSA-75067 +Processing of DNA double-strand break ends REACT:R-HSA-5693607 +Processing of Intronless Pre-mRNAs REACT:R-HSA-77595 +Processive synthesis on the C-strand of the telomere REACT:R-HSA-174414 +Processive synthesis on the lagging strand REACT:R-HSA-69183 +Progesterone-mediated oocyte maturation KEGG:hsa04914 +Programmed Cell Death REACT:R-HSA-5357801 +Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 REACT:R-HSA-964827 +Prolactin receptor signaling REACT:R-HSA-1170546 +Prolactin signaling pathway KEGG:hsa04917 +Proline biosynthesis, glutamate => proline KEGG:hsa_M00015 +Proline catabolism REACT:R-HSA-70688 +Prolonged ERK activation events REACT:R-HSA-169893 +Propanoate metabolism KEGG:hsa00640 +Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA KEGG:hsa_M00741 +Propionyl-CoA catabolism REACT:R-HSA-71032 +Prostacyclin signalling through prostacyclin receptor REACT:R-HSA-392851 +Prostanoid ligand receptors REACT:R-HSA-391908 +Prostate cancer KEGG:hsa05215 +Proteasome KEGG:hsa03050 +Proteasome, 19S regulatory particle (PA700) KEGG:hsa_M00341 +Proteasome, 20S core particle KEGG:hsa_M00340 +Protein digestion and absorption KEGG:hsa04974 +Protein export KEGG:hsa03060 +Protein folding REACT:R-HSA-391251 +Protein methylation REACT:R-HSA-8876725 +Protein processing in endoplasmic reticulum KEGG:hsa04141 +Protein-protein interactions at synapses REACT:R-HSA-6794362 +Protein repair REACT:R-HSA-5676934 +Protein ubiquitination REACT:R-HSA-8852135 +Proteoglycans in cancer KEGG:hsa05205 +Proton-coupled monocarboxylate transport REACT:R-HSA-433692 +Proton-coupled neutral amino acid transporters REACT:R-HSA-428559 +Proton/oligopeptide cotransporters REACT:R-HSA-427975 +Proximal tubule bicarbonate reclamation KEGG:hsa04964 +PRPP biosynthesis, ribose 5P => PRPP KEGG:hsa_M00005 +PTEN Loss of Function in Cancer REACT:R-HSA-5674404 +PTK6 Activates STAT3 REACT:R-HSA-8849474 +PTK6 Down-Regulation REACT:R-HSA-8849472 +PTK6 Expression REACT:R-HSA-8849473 +PTK6 promotes HIF1A stabilization REACT:R-HSA-8857538 +PTK6 Regulates Cell Cycle REACT:R-HSA-8849470 +PTK6 Regulates Proteins Involved in RNA Processing REACT:R-HSA-8849468 +PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases REACT:R-HSA-8849471 +PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 REACT:R-HSA-8849469 +Purine catabolism REACT:R-HSA-74259 +Purine metabolism KEGG:hsa00230 +Purine metabolism REACT:R-HSA-73847 +Purine ribonucleoside monophosphate biosynthesis REACT:R-HSA-73817 +Purine salvage REACT:R-HSA-74217 +Pyrimidine biosynthesis REACT:R-HSA-500753 +Pyrimidine catabolism REACT:R-HSA-73621 +Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate KEGG:hsa_M00046 +Pyrimidine metabolism KEGG:hsa00240 +Pyrimidine metabolism REACT:R-HSA-73848 +Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTP KEGG:hsa_M00052 +Pyrimidine salvage reactions REACT:R-HSA-73614 +Pyrophosphate hydrolysis REACT:R-HSA-71737 +Pyruvate metabolism KEGG:hsa00620 +Pyruvate metabolism REACT:R-HSA-70268 +Pyruvate metabolism and Citric Acid (TCA) cycle REACT:R-HSA-71406 +Pyruvate oxidation, pyruvate => acetyl-CoA KEGG:hsa_M00307 +RAB GEFs exchange GTP for GDP on RABs REACT:R-HSA-8876198 +RAB geranylgeranylation REACT:R-HSA-8873719 +RA biosynthesis pathway REACT:R-HSA-5365859 +RAF activation REACT:R-HSA-5673000 +RAF-independent MAPK1/3 activation REACT:R-HSA-112409 +RAF/MAP kinase cascade REACT:R-HSA-5673001 +Rap1 signaling pathway KEGG:hsa04015 +Rap1 signalling REACT:R-HSA-392517 +Ras activation uopn Ca2+ infux through NMDA receptor REACT:R-HSA-442982 +RAS signaling downstream of NF1 loss-of-function variants REACT:R-HSA-6802953 +Ras signaling pathway KEGG:hsa04014 +Reactions specific to the complex N-glycan synthesis pathway REACT:R-HSA-975578 +Reactions specific to the hybrid N-glycan synthesis pathway REACT:R-HSA-975574 +Recognition and association of DNA glycosylase with site containing an affected purine REACT:R-HSA-110330 +Recognition and association of DNA glycosylase with site containing an affected pyrimidine REACT:R-HSA-110328 +Recognition of DNA damage by PCNA-containing replication complex REACT:R-HSA-110314 +Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks REACT:R-HSA-5693565 +Recruitment of mitotic centrosome proteins and complexes REACT:R-HSA-380270 +Recruitment of NuMA to mitotic centrosomes REACT:R-HSA-380320 +Recycling of bile acids and salts REACT:R-HSA-159418 +Recycling of eIF2:GDP REACT:R-HSA-72731 +Recycling pathway of L1 REACT:R-HSA-437239 +Reduction of cytosolic Ca++ levels REACT:R-HSA-418359 +Reelin signalling pathway REACT:R-HSA-8866376 +Regulated Necrosis REACT:R-HSA-5218859 +Regulated proteolysis of p75NTR REACT:R-HSA-193692 +Regulation by c-FLIP REACT:R-HSA-3371378 +Regulation by TREX1 REACT:R-HSA-3248023 +Regulation of actin cytoskeleton KEGG:hsa04810 +Regulation of actin dynamics for phagocytic cup formation REACT:R-HSA-2029482 +Regulation of activated PAK-2p34 by proteasome mediated degradation REACT:R-HSA-211733 +Regulation of APC/C activators between G1/S and early anaphase REACT:R-HSA-176408 +Regulation of Apoptosis REACT:R-HSA-169911 +Regulation of beta-cell development REACT:R-HSA-186712 +Regulation of cholesterol biosynthesis by SREBP (SREBF) REACT:R-HSA-1655829 +Regulation of Commissural axon pathfinding by Slit and Robo REACT:R-HSA-428542 +Regulation of Complement cascade REACT:R-HSA-977606 +Regulation of cytoskeletal remodeling and cell spreading by IPP complex components REACT:R-HSA-446388 +Regulation of DNA replication REACT:R-HSA-69304 +Regulation of FZD by ubiquitination REACT:R-HSA-4641263 +Regulation of gap junction activity REACT:R-HSA-191650 +Regulation of gene expression by Hypoxia-inducible Factor REACT:R-HSA-1234158 +Regulation of gene expression in beta cells REACT:R-HSA-210745 +Regulation of gene expression in early pancreatic precursor cells REACT:R-HSA-210747 +Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells REACT:R-HSA-210746 +Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells REACT:R-HSA-210744 +Regulation of Glucokinase by Glucokinase Regulatory Protein REACT:R-HSA-170822 +Regulation of HSF1-mediated heat shock response REACT:R-HSA-3371453 +Regulation of Hypoxia-inducible Factor (HIF) by oxygen REACT:R-HSA-1234174 +Regulation of IFNA signaling REACT:R-HSA-912694 +Regulation of IFNG signaling REACT:R-HSA-877312 +Regulation of innate immune responses to cytosolic DNA REACT:R-HSA-3134975 +Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) REACT:R-HSA-381426 +Regulation of insulin secretion REACT:R-HSA-422356 +Regulation of KIT signaling REACT:R-HSA-1433559 +Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) REACT:R-HSA-400206 +Regulation of lipolysis in adipocytes KEGG:hsa04923 +Regulation of mitotic cell cycle REACT:R-HSA-453276 +Regulation of mRNA stability by proteins that bind AU-rich elements REACT:R-HSA-450531 +Regulation of necroptotic cell death REACT:R-HSA-5675482 +Regulation of ornithine decarboxylase (ODC) REACT:R-HSA-350562 +Regulation of PAK-2p34 activity by PS-GAP/RHG10 REACT:R-HSA-211728 +Regulation of PLK1 Activity at G2/M Transition REACT:R-HSA-2565942 +Regulation of pyruvate dehydrogenase (PDH) complex REACT:R-HSA-204174 +Regulation of RAS by GAPs REACT:R-HSA-5658442 +Regulation of signaling by CBL REACT:R-HSA-912631 +Regulation of signaling by NODAL REACT:R-HSA-1433617 +Regulation of thyroid hormone activity REACT:R-HSA-350864 +Regulation of TLR by endogenous ligand REACT:R-HSA-5686938 +Regulation of TNFR1 signaling REACT:R-HSA-5357905 +Regulation of TP53 Activity REACT:R-HSA-5633007 +Regulation of TP53 Activity through Acetylation REACT:R-HSA-6804758 +Regulation of TP53 Activity through Association with Co-factors REACT:R-HSA-6804759 +Regulation of TP53 Activity through Methylation REACT:R-HSA-6804760 +Regulation of TP53 Activity through Phosphorylation REACT:R-HSA-6804756 +Regulation of TP53 Degradation REACT:R-HSA-6804757 +Regulation of TP53 Expression REACT:R-HSA-6804754 +Regulation of TP53 Expression and Degradation REACT:R-HSA-6806003 +Relaxin receptors REACT:R-HSA-444821 +Release REACT:R-HSA-168298 +Release of apoptotic factors from the mitochondria REACT:R-HSA-111457 +Release of Hh-Np from the secreting cell REACT:R-HSA-5362798 +Removal of aminoterminal propeptides from gamma-carboxylated proteins REACT:R-HSA-159782 +Removal of licensing factors from origins REACT:R-HSA-69300 +Removal of the Flap Intermediate REACT:R-HSA-69166 +Removal of the Flap Intermediate from the C-strand REACT:R-HSA-174437 +Renal cell carcinoma KEGG:hsa05211 +Renin-angiotensin system KEGG:hsa04614 +Renin secretion KEGG:hsa04924 +Repression of WNT target genes REACT:R-HSA-4641265 +Reproduction REACT:R-HSA-1474165 +Resolution of Abasic Sites (AP sites) REACT:R-HSA-73933 +Resolution of AP sites via the multiple-nucleotide patch replacement pathway REACT:R-HSA-110373 +Resolution of AP sites via the single-nucleotide replacement pathway REACT:R-HSA-110381 +Resolution of D-Loop Structures REACT:R-HSA-5693537 +Resolution of D-loop Structures through Holliday Junction Intermediates REACT:R-HSA-5693568 +Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) REACT:R-HSA-5693554 +Resolution of Sister Chromatid Cohesion REACT:R-HSA-2500257 +Respiratory electron transport REACT:R-HSA-611105 +Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. REACT:R-HSA-163200 +Response of Mtb to phagocytosis REACT:R-HSA-1222499 +Response to elevated platelet cytosolic Ca2+ REACT:R-HSA-76005 +Response to metal ions REACT:R-HSA-5660526 +Retinoid cycle disease events REACT:R-HSA-2453864 +Retinoid metabolism and transport REACT:R-HSA-975634 +Retinoid metabolism disease events REACT:R-HSA-6809583 +Retinol metabolism KEGG:hsa00830 +Retrograde endocannabinoid signaling KEGG:hsa04723 +Retrograde neurotrophin signalling REACT:R-HSA-177504 +Retrograde transport at the Trans-Golgi-Network REACT:R-HSA-6811440 +RET signaling REACT:R-HSA-8853659 +Reuptake of GABA REACT:R-HSA-888593 +Reversal of alkylation damage by DNA dioxygenases REACT:R-HSA-73943 +Reverse Transcription of HIV RNA REACT:R-HSA-162589 +Reversible hydration of carbon dioxide REACT:R-HSA-1475029 +Rev-mediated nuclear export of HIV RNA REACT:R-HSA-165054 +RF-C complex KEGG:hsa_M00289 +Rhesus glycoproteins mediate ammonium transport. REACT:R-HSA-444411 +Rheumatoid arthritis KEGG:hsa05323 +Rho GTPase cycle REACT:R-HSA-194840 +RHO GTPase Effectors REACT:R-HSA-195258 +RHO GTPases activate CIT REACT:R-HSA-5625900 +RHO GTPases Activate Formins REACT:R-HSA-5663220 +RHO GTPases activate IQGAPs REACT:R-HSA-5626467 +RHO GTPases activate KTN1 REACT:R-HSA-5625970 +RHO GTPases Activate NADPH Oxidases REACT:R-HSA-5668599 +RHO GTPases activate PAKs REACT:R-HSA-5627123 +RHO GTPases activate PKNs REACT:R-HSA-5625740 +RHO GTPases Activate Rhotekin and Rhophilins REACT:R-HSA-5666185 +RHO GTPases Activate ROCKs REACT:R-HSA-5627117 +RHO GTPases Activate WASPs and WAVEs REACT:R-HSA-5663213 +RHO GTPases regulate CFTR trafficking REACT:R-HSA-5627083 +Riboflavin metabolism KEGG:hsa00740 +Ribosomal scanning and start codon recognition REACT:R-HSA-72702 +Ribosome KEGG:hsa03010 +Ribosome biogenesis in eukaryotes KEGG:hsa03008 +Ribosome, eukaryotes KEGG:hsa_M00177 +RIG-I-like receptor signaling pathway KEGG:hsa04622 +RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways REACT:R-HSA-168928 +RIPK1-mediated regulated necrosis REACT:R-HSA-5213460 +RIP-mediated NFkB activation via ZBP1 REACT:R-HSA-1810476 +RMTs methylate histone arginines REACT:R-HSA-3214858 +RNA degradation KEGG:hsa03018 +RNA Pol II CTD phosphorylation and interaction with CE REACT:R-HSA-77075 +RNA Pol II CTD phosphorylation and interaction with CE during HIV infection REACT:R-HSA-167160 +RNA polymerase KEGG:hsa03020 +RNA Polymerase I Chain Elongation REACT:R-HSA-73777 +RNA polymerase I, eukaryotes KEGG:hsa_M00182 +RNA polymerase II, eukaryotes KEGG:hsa_M00180 +RNA Polymerase II HIV Promoter Escape REACT:R-HSA-167162 +RNA Polymerase III Abortive And Retractive Initiation REACT:R-HSA-749476 +RNA Polymerase III Chain Elongation REACT:R-HSA-73780 +RNA polymerase III, eukaryotes KEGG:hsa_M00181 +RNA Polymerase III Transcription REACT:R-HSA-74158 +RNA Polymerase III Transcription Initiation REACT:R-HSA-76046 +RNA Polymerase III Transcription Initiation From Type 1 Promoter REACT:R-HSA-76061 +RNA Polymerase III Transcription Initiation From Type 2 Promoter REACT:R-HSA-76066 +RNA Polymerase III Transcription Initiation From Type 3 Promoter REACT:R-HSA-76071 +RNA Polymerase III Transcription Termination REACT:R-HSA-73980 +RNA Polymerase II Pre-transcription Events REACT:R-HSA-674695 +RNA Polymerase II Promoter Escape REACT:R-HSA-73776 +RNA polymerase II transcribes snRNA genes REACT:R-HSA-6807505 +RNA Polymerase II Transcription REACT:R-HSA-73857 +RNA Polymerase II Transcription Elongation REACT:R-HSA-75955 +RNA Polymerase II Transcription Initiation REACT:R-HSA-75953 +RNA Polymerase II Transcription Initiation And Promoter Clearance REACT:R-HSA-76042 +RNA Polymerase II Transcription Pre-Initiation And Promoter Opening REACT:R-HSA-73779 +RNA Polymerase II Transcription Termination REACT:R-HSA-73856 +RNA Polymerase I Promoter Clearance REACT:R-HSA-73854 +RNA Polymerase I Promoter Escape REACT:R-HSA-73772 +RNA Polymerase I Promoter Opening REACT:R-HSA-73728 +RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription REACT:R-HSA-504046 +RNA Polymerase I Transcription REACT:R-HSA-73864 +RNA Polymerase I Transcription Initiation REACT:R-HSA-73762 +RNA Polymerase I Transcription Termination REACT:R-HSA-73863 +RNA transport KEGG:hsa03013 +RNF mutants show enhanced WNT signaling and proliferation REACT:R-HSA-5340588 +Role of Abl in Robo-Slit signaling REACT:R-HSA-428890 +Role of LAT2/NTAL/LAB on calcium mobilization REACT:R-HSA-2730905 +Role of phospholipids in phagocytosis REACT:R-HSA-2029485 +Role of second messengers in netrin-1 signaling REACT:R-HSA-418890 +RORA activates gene expression REACT:R-HSA-1368082 +ROS, RNS production in phagocytes REACT:R-HSA-1222556 +RPA complex KEGG:hsa_M00288 +RPIA deficiency: failed conversion of R5P to RU5P REACT:R-HSA-5659996 +RPIA deficiency: failed conversion of RU5P to R5P REACT:R-HSA-6791461 +rRNA modification in the mitochondrion REACT:R-HSA-6793080 +rRNA modification in the nucleus and cytosol REACT:R-HSA-6790901 +rRNA processing REACT:R-HSA-72312 +rRNA processing in the mitochondrion REACT:R-HSA-8868766 +rRNA processing in the nucleus and cytosol REACT:R-HSA-8868773 +RSK activation REACT:R-HSA-444257 +S33 mutants of beta-catenin aren't phosphorylated REACT:R-HSA-5358747 +S37 mutants of beta-catenin aren't phosphorylated REACT:R-HSA-5358749 +S45 mutants of beta-catenin aren't phosphorylated REACT:R-HSA-5358751 +Salivary secretion KEGG:hsa04970 +Salmonella infection KEGG:hsa05132 +SALM protein interactions at the synapses REACT:R-HSA-8849932 +Scavenging by Class A Receptors REACT:R-HSA-3000480 +Scavenging by Class B Receptors REACT:R-HSA-3000471 +Scavenging by Class F Receptors REACT:R-HSA-3000484 +Scavenging by Class H Receptors REACT:R-HSA-3000497 +Scavenging of heme from plasma REACT:R-HSA-2168880 +SCF-beta-TrCP mediated degradation of Emi1 REACT:R-HSA-174113 +SCF-BTRC complex KEGG:hsa_M00380 +SCF-FBS complex KEGG:hsa_M00382 +SCF-FBW7 complex KEGG:hsa_M00387 +SCF-SKP2 complex KEGG:hsa_M00381 +SCF(Skp2)-mediated degradation of p27/p21 REACT:R-HSA-187577 +Sec61 complex KEGG:hsa_M00401 +Selenoamino acid metabolism REACT:R-HSA-2408522 +Selenocompound metabolism KEGG:hsa00450 +Selenocysteine synthesis REACT:R-HSA-2408557 +Sema3A PAK dependent Axon repulsion REACT:R-HSA-399954 +SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion REACT:R-HSA-399955 +Sema4D induced cell migration and growth-cone collapse REACT:R-HSA-416572 +Sema4D in semaphorin signaling REACT:R-HSA-400685 +Sema4D mediated inhibition of cell attachment and migration REACT:R-HSA-416550 +Semaphorin interactions REACT:R-HSA-373755 +SeMet incorporation into proteins REACT:R-HSA-2408517 +Senescence-Associated Secretory Phenotype (SASP) REACT:R-HSA-2559582 +Sensing of DNA Double Strand Breaks REACT:R-HSA-5693548 +Separation of Sister Chromatids REACT:R-HSA-2467813 +Serine biosynthesis REACT:R-HSA-977347 +Serine biosynthesis, glycerate-3P => serine KEGG:hsa_M00020 +Serotonergic synapse KEGG:hsa04726 +Serotonin and melatonin biosynthesis REACT:R-HSA-209931 +Serotonin clearance from the synaptic cleft REACT:R-HSA-380615 +Serotonin Neurotransmitter Release Cycle REACT:R-HSA-181429 +Serotonin receptors REACT:R-HSA-390666 +Severe congenital neutropenia type 4 (G6PC3) REACT:R-HSA-3282872 +SHC1 events in EGFR signaling REACT:R-HSA-180336 +SHC1 events in ERBB2 signaling REACT:R-HSA-1250196 +SHC1 events in ERBB4 signaling REACT:R-HSA-1250347 +SHC-mediated cascade:FGFR1 REACT:R-HSA-5654688 +SHC-mediated cascade:FGFR2 REACT:R-HSA-5654699 +SHC-mediated cascade:FGFR3 REACT:R-HSA-5654704 +SHC-mediated cascade:FGFR4 REACT:R-HSA-5654719 +SHC-related events triggered by IGF1R REACT:R-HSA-2428933 +Shelterin complex KEGG:hsa_M00424 +Shigellosis KEGG:hsa05131 +Sialic acid metabolism REACT:R-HSA-4085001 +Signal amplification REACT:R-HSA-392518 +Signal attenuation REACT:R-HSA-74749 +Signaling by activated point mutants of FGFR1 REACT:R-HSA-1839122 +Signaling by activated point mutants of FGFR3 REACT:R-HSA-1839130 +Signaling by Activin REACT:R-HSA-1502540 +Signaling by BMP REACT:R-HSA-201451 +Signaling by BRAF and RAF fusions REACT:R-HSA-6802952 +Signaling by cytosolic FGFR1 fusion mutants REACT:R-HSA-1839117 +Signaling by EGFR REACT:R-HSA-177929 +Signaling by EGFR in Cancer REACT:R-HSA-1643713 +Signaling by EGFRvIII in Cancer REACT:R-HSA-5637812 +Signaling by ERBB2 REACT:R-HSA-1227986 +Signaling by ERBB4 REACT:R-HSA-1236394 +Signaling by FGFR REACT:R-HSA-190236 +Signaling by FGFR1 REACT:R-HSA-5654736 +Signaling by FGFR1 amplification mutants REACT:R-HSA-1839120 +Signaling by FGFR1 in disease REACT:R-HSA-5655302 +Signaling by FGFR2 REACT:R-HSA-5654738 +Signaling by FGFR2 amplification mutants REACT:R-HSA-2023837 +Signaling by FGFR2 fusions REACT:R-HSA-8853333 +Signaling by FGFR2 IIIa TM REACT:R-HSA-8851708 +Signaling by FGFR2 in disease REACT:R-HSA-5655253 +Signaling by FGFR3 REACT:R-HSA-5654741 +Signaling by FGFR3 fusions in cancer REACT:R-HSA-8853334 +Signaling by FGFR3 in disease REACT:R-HSA-5655332 +Signaling by FGFR3 point mutants in cancer REACT:R-HSA-8853338 +Signaling by FGFR4 REACT:R-HSA-5654743 +Signaling by FGFR4 in disease REACT:R-HSA-5655291 +Signaling by FGFR in disease REACT:R-HSA-1226099 +Signaling by GPCR REACT:R-HSA-372790 +Signaling by Hedgehog REACT:R-HSA-5358351 +Signaling by high-kinase activity BRAF mutants REACT:R-HSA-6802948 +Signaling by Hippo REACT:R-HSA-2028269 +Signaling by Insulin receptor REACT:R-HSA-74752 +Signaling by Interleukins REACT:R-HSA-449147 +Signaling by Leptin REACT:R-HSA-2586552 +Signaling by Ligand-Responsive EGFR Variants in Cancer REACT:R-HSA-5637815 +Signaling by MET REACT:R-HSA-6806834 +Signaling by moderate kinase activity BRAF mutants REACT:R-HSA-6802946 +Signaling by MST1 REACT:R-HSA-8852405 +Signaling by NODAL REACT:R-HSA-1181150 +Signaling by NOTCH REACT:R-HSA-157118 +Signaling by NOTCH1 REACT:R-HSA-1980143 +Signaling by NOTCH1 HD Domain Mutants in Cancer REACT:R-HSA-2691230 +Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer REACT:R-HSA-2894858 +Signaling by NOTCH1 in Cancer REACT:R-HSA-2644603 +Signaling by NOTCH1 PEST Domain Mutants in Cancer REACT:R-HSA-2644602 +Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant REACT:R-HSA-2660825 +Signaling by NOTCH2 REACT:R-HSA-1980145 +Signaling by NOTCH3 REACT:R-HSA-1980148 +Signaling by NOTCH4 REACT:R-HSA-1980150 +Signaling by Overexpressed Wild-Type EGFR in Cancer REACT:R-HSA-5638302 +Signaling by PDGF REACT:R-HSA-186797 +Signaling by plasma membrane FGFR1 fusions REACT:R-HSA-8853336 +Signaling by PTK6 REACT:R-HSA-8848021 +Signaling by RAS mutants REACT:R-HSA-6802949 +Signaling by Retinoic Acid REACT:R-HSA-5362517 +Signaling by Rho GTPases REACT:R-HSA-194315 +Signaling by Robo receptor REACT:R-HSA-376176 +Signaling by SCF-KIT REACT:R-HSA-1433557 +Signaling by TGF-beta Receptor Complex REACT:R-HSA-170834 +Signaling by TGF-beta Receptor Complex in Cancer REACT:R-HSA-3304351 +Signaling by the B Cell Receptor (BCR) REACT:R-HSA-983705 +Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) REACT:R-HSA-2404192 +Signaling by VEGF REACT:R-HSA-194138 +Signaling by Wnt REACT:R-HSA-195721 +Signaling by WNT in cancer REACT:R-HSA-4791275 +Signaling pathways regulating pluripotency of stem cells KEGG:hsa04550 +Signalling by NGF REACT:R-HSA-166520 +Signalling to ERK5 REACT:R-HSA-198765 +Signalling to ERKs REACT:R-HSA-187687 +Signalling to p38 via RIT and RIN REACT:R-HSA-187706 +Signalling to RAS REACT:R-HSA-167044 +Signalling to STAT3 REACT:R-HSA-198745 +Signal regulatory protein (SIRP) family interactions REACT:R-HSA-391160 +Signal Transduction REACT:R-HSA-162582 +Signal transduction by L1 REACT:R-HSA-445144 +SIRT1 negatively regulates rRNA Expression REACT:R-HSA-427359 +Ski complex KEGG:hsa_M00392 +SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs REACT:R-HSA-77588 +SLBP independent Processing of Histone Pre-mRNAs REACT:R-HSA-111367 +SLC-mediated transmembrane transport REACT:R-HSA-425407 +SLC transporter disorders REACT:R-HSA-5619102 +SMAC binds to IAPs REACT:R-HSA-111463 +SMAC-mediated apoptotic response REACT:R-HSA-111469 +SMAC-mediated dissociation of IAP:caspase complexes REACT:R-HSA-111464 +SMAD2/3 MH2 Domain Mutants in Cancer REACT:R-HSA-3315487 +SMAD2/3 Phosphorylation Motif Mutants in Cancer REACT:R-HSA-3304356 +SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription REACT:R-HSA-2173796 +SMAD4 MH2 Domain Mutants in Cancer REACT:R-HSA-3311021 +Small cell lung cancer KEGG:hsa05222 +Small interfering RNA (siRNA) biogenesis REACT:R-HSA-426486 +Sm core complex KEGG:hsa_M00398 +Smooth Muscle Contraction REACT:R-HSA-445355 +SNARE interactions in vesicular transport KEGG:hsa04130 +snRNP Assembly REACT:R-HSA-191859 +Sodium/Calcium exchangers REACT:R-HSA-425561 +Sodium-coupled phosphate cotransporters REACT:R-HSA-427652 +Sodium-coupled sulphate, di- and tri-carboxylate transporters REACT:R-HSA-433137 +Sodium/Proton exchangers REACT:R-HSA-425986 +SOS-mediated signalling REACT:R-HSA-112412 +Sperm Motility And Taxes REACT:R-HSA-1300642 +Sperm:Oocyte Membrane Binding REACT:R-HSA-1300652 +S Phase REACT:R-HSA-69242 +Sphingolipid de novo biosynthesis REACT:R-HSA-1660661 +Sphingolipid metabolism KEGG:hsa00600 +Sphingolipid metabolism REACT:R-HSA-428157 +Sphingolipid signaling pathway KEGG:hsa04071 +Sphingosine biosynthesis KEGG:hsa_M00099 +Sphingosine degradation KEGG:hsa_M00100 +Spliceosome KEGG:hsa03040 +Spliceosome, 35S U5-snRNP KEGG:hsa_M00355 +Spliceosome, Prp19/CDC5L complex KEGG:hsa_M00353 +Spliceosome, U1-snRNP KEGG:hsa_M00351 +Spliceosome, U2-snRNP KEGG:hsa_M00352 +Spliceosome, U4/U6.U5 tri-snRNP KEGG:hsa_M00354 +Spry regulation of FGF signaling REACT:R-HSA-1295596 +SRP-dependent cotranslational protein targeting to membrane REACT:R-HSA-1799339 +Stabilization of p53 REACT:R-HSA-69541 +Staphylococcus aureus infection KEGG:hsa05150 +Starch and sucrose metabolism KEGG:hsa00500 +STAT6-mediated induction of chemokines REACT:R-HSA-3249367 +Steroid biosynthesis KEGG:hsa00100 +Steroid hormone biosynthesis KEGG:hsa00140 +Steroid hormone biosynthesis, cholesterol => prognenolone => progesterone KEGG:hsa_M00107 +Sterols are 12-hydroxylated by CYP8B1 REACT:R-HSA-211994 +Stimulation of the cell death response by PAK-2p34 REACT:R-HSA-211736 +Stimuli-sensing channels REACT:R-HSA-2672351 +STING mediated induction of host immune responses REACT:R-HSA-1834941 +Striated Muscle Contraction REACT:R-HSA-390522 +Succinate dehydrogenase (ubiquinone) KEGG:hsa_M00148 +Sulfide oxidation to sulfate REACT:R-HSA-1614517 +Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid KEGG:hsa_M00067 +Sulfur amino acid metabolism REACT:R-HSA-1614635 +Sulfur metabolism KEGG:hsa00920 +Sulfur relay system KEGG:hsa04122 +SUMO E3 ligases SUMOylate target proteins REACT:R-HSA-3108232 +SUMO is conjugated to E1 (UBA2:SAE1) REACT:R-HSA-3065676 +SUMO is proteolytically processed REACT:R-HSA-3065679 +SUMO is transferred from E1 to E2 (UBE2I, UBC9) REACT:R-HSA-3065678 +SUMOylation REACT:R-HSA-2990846 +SUMOylation of chromatin organization proteins REACT:R-HSA-4551638 +SUMOylation of DNA damage response and repair proteins REACT:R-HSA-3108214 +SUMOylation of DNA replication proteins REACT:R-HSA-4615885 +SUMOylation of RNA binding proteins REACT:R-HSA-4570464 +SUMOylation of transcription factors REACT:R-HSA-3232118 +Surfactant metabolism REACT:R-HSA-5683826 +Survival motor neuron (SMN) complex KEGG:hsa_M00426 +Switching of origins to a post-replicative state REACT:R-HSA-69052 +Synaptic vesicle cycle KEGG:hsa04721 +Syndecan interactions REACT:R-HSA-3000170 +Synthesis and degradation of ketone bodies KEGG:hsa00072 +Synthesis and interconversion of nucleotide di- and triphosphates REACT:R-HSA-499943 +Synthesis and processing of ENV and VPU REACT:R-HSA-171286 +Synthesis And Processing Of GAG, GAGPOL Polyproteins REACT:R-HSA-174495 +Synthesis of 12-eicosatetraenoic acid derivatives REACT:R-HSA-2142712 +Synthesis of 15-eicosatetraenoic acid derivatives REACT:R-HSA-2142770 +Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) REACT:R-HSA-2142816 +Synthesis of 5-eicosatetraenoic acids REACT:R-HSA-2142688 +Synthesis of active ubiquitin: roles of E1 and E2 enzymes REACT:R-HSA-8866652 +Synthesis of bile acids and bile salts REACT:R-HSA-192105 +Synthesis of bile acids and bile salts via 24-hydroxycholesterol REACT:R-HSA-193775 +Synthesis of bile acids and bile salts via 27-hydroxycholesterol REACT:R-HSA-193807 +Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol REACT:R-HSA-193368 +Synthesis of BMP REACT:R-HSA-1483171 +Synthesis of CL REACT:R-HSA-1483076 +Synthesis of diphthamide-EEF2 REACT:R-HSA-5358493 +Synthesis of DNA REACT:R-HSA-69239 +Synthesis of Dolichyl-phosphate REACT:R-HSA-446199 +Synthesis of dolichyl-phosphate-glucose REACT:R-HSA-480985 +Synthesis of dolichyl-phosphate mannose REACT:R-HSA-162699 +Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) REACT:R-HSA-2142670 +Synthesis of GDP-mannose REACT:R-HSA-446205 +Synthesis of glycosylphosphatidylinositol (GPI) REACT:R-HSA-162710 +Synthesis of Hepoxilins (HX) and Trioxilins (TrX) REACT:R-HSA-2142696 +Synthesis of IP2, IP, and Ins in the cytosol REACT:R-HSA-1855183 +Synthesis of IP3 and IP4 in the cytosol REACT:R-HSA-1855204 +Synthesis of IPs in the ER lumen REACT:R-HSA-1855231 +Synthesis of IPs in the nucleus REACT:R-HSA-1855191 +Synthesis of Ketone Bodies REACT:R-HSA-77111 +Synthesis of Leukotrienes (LT) and Eoxins (EX) REACT:R-HSA-2142691 +Synthesis of Lipoxins (LX) REACT:R-HSA-2142700 +Synthesis of PA REACT:R-HSA-1483166 +Synthesis of PC REACT:R-HSA-1483191 +Synthesis of PE REACT:R-HSA-1483213 +Synthesis of PG REACT:R-HSA-1483148 +Synthesis of PI REACT:R-HSA-1483226 +Synthesis of PIPs at the early endosome membrane REACT:R-HSA-1660516 +Synthesis of PIPs at the ER membrane REACT:R-HSA-1483248 +Synthesis of PIPs at the Golgi membrane REACT:R-HSA-1660514 +Synthesis of PIPs at the late endosome membrane REACT:R-HSA-1660517 +Synthesis of PIPs at the plasma membrane REACT:R-HSA-1660499 +Synthesis of PIPs in the nucleus REACT:R-HSA-8847453 +Synthesis of Prostaglandins (PG) and Thromboxanes (TX) REACT:R-HSA-2162123 +Synthesis of PS REACT:R-HSA-1483101 +Synthesis of pyrophosphates in the cytosol REACT:R-HSA-1855167 +Synthesis of substrates in N-glycan biosythesis REACT:R-HSA-446219 +Synthesis of UDP-N-acetyl-glucosamine REACT:R-HSA-446210 +Synthesis of very long-chain fatty acyl-CoAs REACT:R-HSA-75876 +Synthesis of wybutosine at G37 of tRNA(Phe) REACT:R-HSA-6782861 +Synthesis, secretion, and deacylation of Ghrelin REACT:R-HSA-422085 +Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) REACT:R-HSA-381771 +Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) REACT:R-HSA-400511 +Systemic lupus erythematosus KEGG:hsa05322 +t(4;14) translocations of FGFR3 REACT:R-HSA-2033515 +T41 mutants of beta-catenin aren't phosphorylated REACT:R-HSA-5358752 +Tachykinin receptors bind tachykinins REACT:R-HSA-380095 +TAK1 activates NFkB by phosphorylation and activation of IKKs complex REACT:R-HSA-445989 +TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P REACT:R-HSA-6791462 +TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P REACT:R-HSA-6791055 +Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) REACT:R-HSA-1299308 +Tandem pore domain halothane-inhibited K+ channel (THIK) REACT:R-HSA-1299287 +Tandem pore domain potassium channels REACT:R-HSA-1296346 +Taste transduction KEGG:hsa04742 +Tat-mediated elongation of the HIV-1 transcript REACT:R-HSA-167246 +Tat-mediated HIV elongation arrest and recovery REACT:R-HSA-167243 +Taurine and hypotaurine metabolism KEGG:hsa00430 +TBC/RABGAPs REACT:R-HSA-8854214 +T cell receptor signaling pathway KEGG:hsa04660 +TCF7L2 mutants don't bind CTBP REACT:R-HSA-5339700 +TCF dependent signaling in response to WNT REACT:R-HSA-201681 +TCR signaling REACT:R-HSA-202403 +Telomere C-strand (Lagging Strand) Synthesis REACT:R-HSA-174417 +Telomere C-strand synthesis initiation REACT:R-HSA-174430 +Telomere Extension By Telomerase REACT:R-HSA-171319 +Telomere Maintenance REACT:R-HSA-157579 +Terminal pathway of complement REACT:R-HSA-166665 +Termination of O-glycan biosynthesis REACT:R-HSA-977068 +Termination of translesion DNA synthesis REACT:R-HSA-5656169 +Terpenoid backbone biosynthesis KEGG:hsa00900 +TET1,2,3 and TDG demethylate DNA REACT:R-HSA-5221030 +Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation REACT:R-HSA-1474151 +TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation REACT:R-HSA-8869496 +TFAP2 (AP-2) family regulates transcription of cell cycle factors REACT:R-HSA-8866911 +TFAP2 (AP-2) family regulates transcription of growth factors and their receptors REACT:R-HSA-8866910 +TFAP2 (AP-2) family regulates transcription of other transcription factors REACT:R-HSA-8866906 +TGF-beta receptor signaling activates SMADs REACT:R-HSA-2173789 +TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) REACT:R-HSA-2173791 +TGF-beta signaling KEGG:hsa_M00680 +TGF-beta signaling pathway KEGG:hsa04350 +TGFBR1 KD Mutants in Cancer REACT:R-HSA-3656532 +TGFBR1 LBD Mutants in Cancer REACT:R-HSA-3656535 +TGFBR2 Kinase Domain Mutants in Cancer REACT:R-HSA-3645790 +TGFBR2 MSI Frameshift Mutants in Cancer REACT:R-HSA-3642279 +Th17 cell differentiation KEGG:hsa04659 +Th1 and Th2 cell differentiation KEGG:hsa04658 +THC complex KEGG:hsa_M00405 +The activation of arylsulfatases REACT:R-HSA-1663150 +The AIM2 inflammasome REACT:R-HSA-844615 +The canonical retinoid cycle in rods (twilight vision) REACT:R-HSA-2453902 +The citric acid (TCA) cycle and respiratory electron transport REACT:R-HSA-1428517 +The fatty acid cycling model REACT:R-HSA-167826 +The IPAF inflammasome REACT:R-HSA-844623 +The NLRP1 inflammasome REACT:R-HSA-844455 +The NLRP3 inflammasome REACT:R-HSA-844456 +The phototransduction cascade REACT:R-HSA-2514856 +The proton buffering model REACT:R-HSA-167827 +The retinoid cycle in cones (daylight vision) REACT:R-HSA-2187335 +The role of GTSE1 in G2/M progression after G2 checkpoint REACT:R-HSA-8852276 +The role of Nef in HIV-1 replication and disease pathogenesis REACT:R-HSA-164952 +Thiamine metabolism KEGG:hsa00730 +Threonine catabolism REACT:R-HSA-8849175 +Thrombin signalling through proteinase activated receptors (PARs) REACT:R-HSA-456926 +Thromboxane signalling through TP receptor REACT:R-HSA-428930 +Thyroid cancer KEGG:hsa05216 +Thyroid hormone biosynthesis, tyrosine => triiodothyronine/thyroxine KEGG:hsa_M00043 +Thyroid hormone signaling pathway KEGG:hsa04919 +Thyroid hormone synthesis KEGG:hsa04918 +Thyroxine biosynthesis REACT:R-HSA-209968 +TICAM1 deficiency - HSE REACT:R-HSA-5602566 +Tie2 Signaling REACT:R-HSA-210993 +Tight junction KEGG:hsa04530 +Tight junction interactions REACT:R-HSA-420029 +TLR3 deficiency - HSE REACT:R-HSA-5602410 +TNFR1-induced NFkappaB signaling pathway REACT:R-HSA-5357956 +TNFR1-induced proapoptotic signaling REACT:R-HSA-5357786 +TNFR1-mediated ceramide production REACT:R-HSA-5626978 +TNFR2 non-canonical NF-kB pathway REACT:R-HSA-5668541 +TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway REACT:R-HSA-5676594 +TNFs bind their physiological receptors REACT:R-HSA-5669034 +TNF signaling REACT:R-HSA-75893 +TNF signaling pathway KEGG:hsa04668 +Tolerance by Mtb to nitric oxide produced by macrophages REACT:R-HSA-1222538 +Tolerance of reactive oxygen produced by macrophages REACT:R-HSA-1222387 +Toll Like Receptor 10 (TLR10) Cascade REACT:R-HSA-168142 +Toll Like Receptor 2 (TLR2) Cascade REACT:R-HSA-181438 +Toll Like Receptor 3 (TLR3) Cascade REACT:R-HSA-168164 +Toll Like Receptor 4 (TLR4) Cascade REACT:R-HSA-166016 +Toll Like Receptor 5 (TLR5) Cascade REACT:R-HSA-168176 +Toll Like Receptor 7/8 (TLR7/8) Cascade REACT:R-HSA-168181 +Toll Like Receptor 9 (TLR9) Cascade REACT:R-HSA-168138 +Toll-Like Receptors Cascades REACT:R-HSA-168898 +Toll-like receptor signaling KEGG:hsa_M00686 +Toll-like receptor signaling pathway KEGG:hsa04620 +Toll Like Receptor TLR1:TLR2 Cascade REACT:R-HSA-168179 +Toll Like Receptor TLR6:TLR2 Cascade REACT:R-HSA-168188 +Toxicity of botulinum toxin type A (BoNT/A) REACT:R-HSA-5250968 +Toxicity of botulinum toxin type B (BoNT/B) REACT:R-HSA-5250958 +Toxicity of botulinum toxin type C (BoNT/C) REACT:R-HSA-5250971 +Toxicity of botulinum toxin type D (BoNT/D) REACT:R-HSA-5250955 +Toxicity of botulinum toxin type E (BoNT/E) REACT:R-HSA-5250992 +Toxicity of botulinum toxin type F (BoNT/F) REACT:R-HSA-5250981 +Toxicity of botulinum toxin type G (BoNT/G) REACT:R-HSA-5250989 +Toxicity of tetanus toxin (TeNT) REACT:R-HSA-5250982 +Toxoplasmosis KEGG:hsa05145 +TP53 Regulates Metabolic Genes REACT:R-HSA-5628897 +TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain REACT:R-HSA-6804115 +TP53 Regulates Transcription of Caspase Activators and Caspases REACT:R-HSA-6803207 +TP53 Regulates Transcription of Cell Cycle Genes REACT:R-HSA-6791312 +TP53 Regulates Transcription of Cell Death Genes REACT:R-HSA-5633008 +TP53 Regulates Transcription of Death Receptors and Ligands REACT:R-HSA-6803211 +TP53 Regulates Transcription of DNA Repair Genes REACT:R-HSA-6796648 +TP53 Regulates Transcription of Genes Involved in Cytochrome C Release REACT:R-HSA-6803204 +TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest REACT:R-HSA-6804116 +TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest REACT:R-HSA-6804114 +TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain REACT:R-HSA-6803205 +TRAF3 deficiency - HSE REACT:R-HSA-5602571 +TRAF3-dependent IRF activation pathway REACT:R-HSA-918233 +TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation REACT:R-HSA-975138 +TRAF6 mediated induction of TAK1 complex REACT:R-HSA-937072 +TRAF6 mediated IRF7 activation REACT:R-HSA-933541 +TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling REACT:R-HSA-975110 +TRAF6 mediated NF-kB activation REACT:R-HSA-933542 +Trafficking and processing of endosomal TLR REACT:R-HSA-1679131 +Trafficking of AMPA receptors REACT:R-HSA-399719 +Trafficking of dietary sterols REACT:R-HSA-265473 +Trafficking of GluR2-containing AMPA receptors REACT:R-HSA-416993 +Trafficking of myristoylated proteins to the cilium REACT:R-HSA-5624138 +TRAIL signaling REACT:R-HSA-75158 +TRAMP complex KEGG:hsa_M00393 +Transcriptional activation of cell cycle inhibitor p21 REACT:R-HSA-69895 +Transcriptional activation of mitochondrial biogenesis REACT:R-HSA-2151201 +Transcriptional activation of p53 responsive genes REACT:R-HSA-69560 +Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer REACT:R-HSA-2173793 +Transcriptional misregulation in cancer KEGG:hsa05202 +Transcriptional regulation by small RNAs REACT:R-HSA-5578749 +Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors REACT:R-HSA-8864260 +Transcriptional Regulation by TP53 REACT:R-HSA-3700989 +Transcriptional regulation of pluripotent stem cells REACT:R-HSA-452723 +Transcriptional regulation of white adipocyte differentiation REACT:R-HSA-381340 +Transcription-Coupled Nucleotide Excision Repair (TC-NER) REACT:R-HSA-6781827 +Transcription from mitochondrial promoters REACT:R-HSA-75944 +Transcription of the HIV genome REACT:R-HSA-167172 +Transfer of LPS from LBP carrier to CD14 REACT:R-HSA-166020 +Transferrin endocytosis and recycling REACT:R-HSA-917977 +trans-Golgi Network Vesicle Budding REACT:R-HSA-199992 +Translation REACT:R-HSA-72766 +Translation initiation complex formation REACT:R-HSA-72649 +Translesion Synthesis by POLH REACT:R-HSA-110320 +Translesion synthesis by POLI REACT:R-HSA-5656121 +Translesion synthesis by POLK REACT:R-HSA-5655862 +Translesion synthesis by REV1 REACT:R-HSA-110312 +Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template REACT:R-HSA-110313 +Translocation of GLUT4 to the plasma membrane REACT:R-HSA-1445148 +Translocation of ZAP-70 to Immunological synapse REACT:R-HSA-202430 +Translocon-associated protein (TRAP) complex KEGG:hsa_M00402 +Transmembrane transport of small molecules REACT:R-HSA-382551 +Transmission across Chemical Synapses REACT:R-HSA-112315 +Transmission across Electrical Synapses REACT:R-HSA-112307 +Transport and synthesis of PAPS REACT:R-HSA-174362 +Transport of connexins along the secretory pathway REACT:R-HSA-190827 +Transport of connexons to the plasma membrane REACT:R-HSA-190872 +Transport of fatty acids REACT:R-HSA-804914 +Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus REACT:R-HSA-159763 +Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds REACT:R-HSA-425366 +Transport of glycerol from adipocytes to the liver by Aquaporins REACT:R-HSA-432030 +Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus REACT:R-HSA-168874 +Transport of inorganic cations/anions and amino acids/oligopeptides REACT:R-HSA-425393 +Transport of Mature mRNA derived from an Intron-Containing Transcript REACT:R-HSA-159236 +Transport of Mature mRNA Derived from an Intronless Transcript REACT:R-HSA-159231 +Transport of Mature mRNAs Derived from Intronless Transcripts REACT:R-HSA-159234 +Transport of Mature Transcript to Cytoplasm REACT:R-HSA-72202 +Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane REACT:R-HSA-83936 +Transport of nucleotide sugars REACT:R-HSA-727802 +Transport of organic anions REACT:R-HSA-879518 +Transport of Ribonucleoproteins into the Host Nucleus REACT:R-HSA-168271 +Transport of the SLBP Dependant Mature mRNA REACT:R-HSA-159230 +Transport of the SLBP independent Mature mRNA REACT:R-HSA-159227 +Transport of vitamins, nucleosides, and related molecules REACT:R-HSA-425397 +Transport to the Golgi and subsequent modification REACT:R-HSA-948021 +TREX complex KEGG:hsa_M00406 +Triacylglycerol biosynthesis KEGG:hsa_M00089 +TRIF-mediated programmed cell death REACT:R-HSA-2562578 +TRIF-mediated TLR3/TLR4 signaling REACT:R-HSA-937061 +Triglyceride Biosynthesis REACT:R-HSA-75109 +Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA REACT:R-HSA-450513 +TRKA activation by NGF REACT:R-HSA-187042 +tRNA Aminoacylation REACT:R-HSA-379724 +tRNA modification in the mitochondrion REACT:R-HSA-6787450 +tRNA modification in the nucleus and cytosol REACT:R-HSA-6782315 +tRNA processing REACT:R-HSA-72306 +tRNA processing in the mitochondrion REACT:R-HSA-6785470 +tRNA processing in the nucleus REACT:R-HSA-6784531 +TRP channels REACT:R-HSA-3295583 +truncated APC mutants destabilize the destruction complex REACT:R-HSA-4839744 +Truncations of AMER1 destabilize the destruction complex REACT:R-HSA-5467348 +Tryptophan catabolism REACT:R-HSA-71240 +Tryptophan metabolism KEGG:hsa00380 +Tuberculosis KEGG:hsa05152 +TWIK-related alkaline pH activated K+ channel (TALK) REACT:R-HSA-1299361 +TWIK related potassium channel (TREK) REACT:R-HSA-1299503 +TWIK-related spinal cord K+ channel (TRESK) REACT:R-HSA-1299344 +TWIK-releated acid-sensitive K+ channel (TASK) REACT:R-HSA-1299316 +Type I diabetes mellitus KEGG:hsa04940 +Type I hemidesmosome assembly REACT:R-HSA-446107 +Type II diabetes mellitus KEGG:hsa04930 +Type II Na+/Pi cotransporters REACT:R-HSA-427589 +Tyrosine degradation, tyrosine => homogentisate KEGG:hsa_M00044 +Tyrosine metabolism KEGG:hsa00350 +Ubiquinol biosynthesis REACT:R-HSA-2142789 +Ubiquinone and other terpenoid-quinone biosynthesis KEGG:hsa00130 +Ubiquinone biosynthesis, eukaryotes, 4-hydroxybenzoate => ubiquinone KEGG:hsa_M00128 +Ubiquitin-dependent degradation of Cyclin D REACT:R-HSA-75815 +Ubiquitin-dependent degradation of Cyclin D1 REACT:R-HSA-69229 +Ubiquitin Mediated Degradation of Phosphorylated Cdc25A REACT:R-HSA-69601 +Ubiquitin mediated proteolysis KEGG:hsa04120 +Ub-specific processing proteases REACT:R-HSA-5689880 +UCH proteinases REACT:R-HSA-5689603 +Unblocking of NMDA receptor, glutamate binding and activation REACT:R-HSA-438066 +UNC93B1 deficiency - HSE REACT:R-HSA-5602415 +Uncoating of the HIV Virion REACT:R-HSA-162585 +Uncoating of the Influenza Virion REACT:R-HSA-168336 +Unfolded Protein Response (UPR) REACT:R-HSA-381119 +Unwinding of DNA REACT:R-HSA-176974 +Uptake and actions of bacterial toxins REACT:R-HSA-5339562 +Uptake and function of anthrax toxins REACT:R-HSA-5210891 +Uptake and function of diphtheria toxin REACT:R-HSA-5336415 +Urea cycle KEGG:hsa_M00029 +Urea cycle REACT:R-HSA-70635 +Uridine monophosphate biosynthesis, glutamine (+ PRPP) => UMP KEGG:hsa_M00051 +Utilization of Ketone Bodies REACT:R-HSA-77108 +Valine, leucine and isoleucine biosynthesis KEGG:hsa00290 +Valine, leucine and isoleucine degradation KEGG:hsa00280 +Variant SLC6A14 may confer susceptibility towards obesity REACT:R-HSA-5619094 +Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) REACT:R-HSA-5619101 +Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) REACT:R-HSA-5660686 +Vascular smooth muscle contraction KEGG:hsa04270 +Vasopressin-like receptors REACT:R-HSA-388479 +Vasopressin-regulated water reabsorption KEGG:hsa04962 +Vasopressin regulates renal water homeostasis via Aquaporins REACT:R-HSA-432040 +VEGFA-VEGFR2 Pathway REACT:R-HSA-4420097 +VEGF binds to VEGFR leading to receptor dimerization REACT:R-HSA-195399 +VEGF ligand-receptor interactions REACT:R-HSA-194313 +VEGFR2 mediated cell proliferation REACT:R-HSA-5218921 +VEGFR2 mediated vascular permeability REACT:R-HSA-5218920 +VEGF signaling pathway KEGG:hsa04370 +Vesicle-mediated transport REACT:R-HSA-5653656 +Vibrio cholerae infection KEGG:hsa05110 +Vif-mediated degradation of APOBEC3G REACT:R-HSA-180585 +Viral carcinogenesis KEGG:hsa05203 +Viral Messenger RNA Synthesis REACT:R-HSA-168325 +Viral mRNA Translation REACT:R-HSA-192823 +Viral myocarditis KEGG:hsa05416 +Viral RNP Complexes in the Host Cell Nucleus REACT:R-HSA-168330 +Virus Assembly and Release REACT:R-HSA-168268 +Visual phototransduction REACT:R-HSA-2187338 +Vitamin B1 (thiamin) metabolism REACT:R-HSA-196819 +Vitamin B2 (riboflavin) metabolism REACT:R-HSA-196843 +Vitamin B5 (pantothenate) metabolism REACT:R-HSA-199220 +Vitamin B6 metabolism KEGG:hsa00750 +Vitamin C (ascorbate) metabolism REACT:R-HSA-196836 +Vitamin D (calciferol) metabolism REACT:R-HSA-196791 +Vitamin digestion and absorption KEGG:hsa04977 +Vitamins REACT:R-HSA-211916 +Vitamins B6 activation to pyridoxal phosphate REACT:R-HSA-964975 +VLDL biosynthesis REACT:R-HSA-8866423 +VLDL interactions REACT:R-HSA-8855121 +VLDLR internalisation and degradation REACT:R-HSA-8866427 +Voltage gated Potassium channels REACT:R-HSA-1296072 +Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization REACT:R-HSA-180897 +Vpr-mediated nuclear import of PICs REACT:R-HSA-180910 +Vpu mediated degradation of CD4 REACT:R-HSA-180534 +vRNA Synthesis REACT:R-HSA-192814 +vRNP Assembly REACT:R-HSA-192905 +V-type ATPase, eukaryotes KEGG:hsa_M00160 +VxPx cargo-targeting to cilium REACT:R-HSA-5620916 +Wax biosynthesis REACT:R-HSA-8848584 +WNT5A-dependent internalization of FZD2, FZD5 and ROR2 REACT:R-HSA-5140745 +WNT5A-dependent internalization of FZD4 REACT:R-HSA-5099900 +WNT ligand biogenesis and trafficking REACT:R-HSA-3238698 +WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 REACT:R-HSA-5340573 +WNT mediated activation of DVL REACT:R-HSA-201688 +Wnt signaling KEGG:hsa_M00677 +Wnt signaling pathway KEGG:hsa04310 +XAV939 inhibits tankyrase, stabilizing AXIN REACT:R-HSA-5545619 +XBP1(S) activates chaperone genes REACT:R-HSA-381038 +Xenobiotics REACT:R-HSA-211981 +YAP1- and WWTR1 (TAZ)-stimulated gene expression REACT:R-HSA-2032785 +ZBP1(DAI) mediated induction of type I IFNs REACT:R-HSA-1606322 +Zinc efflux and compartmentalization by the SLC30 family REACT:R-HSA-435368 +Zinc influx into cells by the SLC39 gene family REACT:R-HSA-442380 +Zinc transporters REACT:R-HSA-435354