近年来代表性论文1.LinJ,LaiM,HuangQ,MaY,CuiJ,RuanW.MethylationpatternsofIGFBP7incoloncancercelllinesareassociatedwithlevelsofgeneexpression.TheJournalofpathology2007;212:83-90.IF5.4232.LuB,XuJ,ZhuY,ZhangH,LaiM.Systemicanalysisofthedifferentialgeneexpressionprofileinacolonicadenoma-normalSSHlibrary.Clinicachimicaacta;internationaljournalofclinicalchemistry2007;378:42-7.IF2.6013.MDL,Xujing.Ribosomalproteinsandcolorectalcancer.CurrentGenomics2007;8:43-9.IF0.5734.RuanW,LaiM.Actin,areliablemarkerofinternalcontrol?Clinicachimicaacta;internationaljournalofclinicalchemistry2007;385:1-5.IF2.6015.RuanW,XuE,XuF,etal.IGFBP7playsapotentialtumorsuppressorroleincolorectalcarcinogenesis.Cancerbiology&therapy2007;6:354-9.IF2.8736.WangY,MaY,LuB,XuE,HuangQ,LaiM.Differentialexpressionofmimecanandthioredoxindomain-containingprotein5incolorectaladenomaandcancer:aproteomicstudy.ExpBiolMed(Maywood)2007;232:1152-9.IF1.9797.XuE,XiaX,LuB,etal.Associationofmatrixmetalloproteinase-2and-9promoterpolymorphismswithcolorectalcancerinChinese.MolCarcinog2007.IF3.1948.XuF,WangF,DiM,etal.Classificationbasedonthecombinationofmolecularandpathologicpredictorsissuperiortomolecularclassificationonprognosisincolorectalcarcinoma.ClinCancerRes2007;13:5082-8.IF6.259.YeF,ChenY,KnoselT,etal.Decreasedexpressionofinsulin-likegrowthfactorbindingprotein7inhumancolorectalcarcinomaisrelatedtoDNAmethylation.Journalofcancerresearchandclinicaloncology2007;133:305-14.IF2.36610.ZhuY,LaiM,YangH,etal.Genotypes,haplotypesanddiplotypesofXPCandriskofbladdercancer.Carcinogenesis2007;28:698-703.IF5.40611.ZhuYM,HuangQ,LinJ,HuY,ChenJ,LaiMD.ExpressionofhumanDNAmethyltransferase1incolorectalcancertissuesandtheircorrespondingdistantnormaltissues.Internationaljournalofcolorectaldisease2007;22:661-6.IF1.91812.KangL,LuB,XuJ,HuH,LaiM.DownregulationofKruppel-likefactor9inhumancolorectalcancer.PatholInt2008;58:334-8.IF1.37113.LuB,FangY,XuJ,etal.AnalysisofSOX9expressionincolorectalcancer.AmJClinPathol2008;130:897-904.IF2.62914.LuB,XuJ,ChenJ,YuJ,XuE,LaiM.TaqManlowdensityarrayisroughlyrightforgeneexpressionquantificationincolorectalcancer.Clinicachimicaacta;internationaljournalofclinicalchemistry2008;389:146-51.IF2.60115.MaY,LuB,RuanW,etal.Tumorsuppressorgeneinsulin-likegrowthfactorbindingprotein-relatedprotein1(IGFBP-rP1)inducessenescence-likegrowtharrestincolorectalcancercells.ExpMolPathol2008;85:141-5.IF1.82216.TengX,YuX,WangG,XuL,LaiM.Sclerosingangiomatoidnodulartransformationofthespleen.AnalQuantCytolHistol2008;30:125-32.IF0.98917.XuJ,LuB,XuF,etal.Dynamicdown-regulationofKruppel-likefactor4incolorectaladenoma-carcinomasequence.Journalofcancerresearchandclinicaloncology2008;134:891-8.IF2.36618.XueH,LuB,LaiM.Thecancersecretome:areservoirofbiomarkers.JTranslMed2008;6:52.IF2.93519.LinJ,LaiM,HuangQ,RuanW,MaY,CuiJ.ReactivationofIGFBP7byDNAdemethylationinhibitshumancoloncancercellgrowthinvitro.CancerBiolTher.2008Dec;7(12):1896-900IF2.76120.LiFY,LaiMD.Colorectalcancer,oneentityorthree.JZhejiangUnivSciB.2009Mar;10(3):219-29IF1.67921.XiaX,XuE,QuanS,HuangQ,LaiM.NoassociationbetweenthepolymorphismsinCDX2codingregionsandcolorectalcancerinChinese.MolCellBiochem.2009Nov;331(1-2):27-30IF1.76422.LüB,YuJ,XuJ,ChenJ,LaiM.Anovelapproachtodetectdifferentiallyexpressedgenesfromcount-baseddigitaldatabasesbynormalizingwithhousekeepinggenes.Genomics.2009Sep;94(3):211-6IF3.07523.XuF,XuJ,LouZ,DiM,WangF,HuH,LaiM.MicropapillarycomponentincolorectalcarcinomaisassociatedwithlymphnodemetastasisinT1andT2StagesanddecreasedsurvivaltimeinTNMstagesIandII.AmJSurgPathol.2009Sep;33(9):1287-92IF4.0224.RuanW,LaiM.Insulin-likegrowthfactorbindingprotein:apossiblemarkerforthemetabolicsyndrome?ActaDiabetol.2009Sep22IF0.92625.RenX,ZhangX,ZhangX,GuW,ChenK,LeY,LaiM,ZhuY.Type2diabetesmellitusassociatedwithincreasedriskforcolorectalcancer:evidencefromaninternationalecologicalstudyandpopulation-basedriskanalysisinChina.PublicHealth.2009Aug;123(8):540-4.IF1.20426.XueH,LuB,ZhangJ,WuM,HuangQ,WuQ,ShengH,WuD,HuJ,LaiM.Identificationoftrefoilfactor3andgrowth/differentiationfactor15aspotentialbiomarkersforcolorectalcancerusingadifferentialsecretomeapproach.JProteomeRes.2010Jan;9(1):545-55.IF5.68427.ZhangH,LiY,LaiM.ThemicroRNAnetworkandtumormetastasis.Oncogene.2010Feb18;29(7):937-48.IF7.21628.LiF,RenX,XuE,HuangQ,ShengH,LvB,LaiM.RegIVexpressionshowingspecificitytogastrointestinaltractanditspotentialroleindiagnosingdigestivetractneuroendocrinetumor.JZhejiangUnivSciB.2010Apr;11(4):258-66.IF1.679学术成果1.ZhangH,LiY,HuangQ,RenX,HuH,ShengH,LaiM*.MiR-148apromotesapoptosisbytargetingBcl-2incolorectalcancer.CellDeathDiffer.2011.18(11):1702-102.XueH,LiB,ZhangJ,WuM,HuangQ,WuQ,ShengH,WuD,HuJ,LaiM*.IdentificationofSerumBiomarkersforColorectalCancerMetastasisUsingaDifferentialSecretomeApproach.JProteomeRes.2010.9(1):545-55.3.LinJ,LaiM*,HuangQ,MaY,CuiJ,andWRuan.MethylationpatternsofIGFBP7incoloncancercelllinesareassociatedwithlevelsofgeneexpression.JPathol,2007.212(1):83-90.《IntraepithelialNeoplasia》Springer2009Mar4.一种人小RNA-148a表达载体及应用5.一种从陈旧福尔马林固定组织提取DNA的方法6.抗人SCGN的单克隆抗体及其制备与应用以及杂交瘤细胞株7.抗人Reg4的单克隆抗体及其制备与应用以及杂交瘤细胞株8.大气污染物对肺泡巨噬细胞的作用（排2）;1988年卫生部科学技术进步二等奖9.分子病理研究平台的构建和结直肠癌相关生物标志物的筛选（排1）2005年浙江省科技进步一等奖10.独立学院培养高素质应用型人才的探索与实践（排1）;2005年国家教学成果二等奖11.研究生培养机制的改革与实践（排3）;2009年高等教育国家级教学成果二等奖12.病理学系列教材的建设与实践（排4）;2009年高等教育国家级教学成果二等奖13.大肠癌诊断和预后相关标志物的鉴定及应用（排1）2011年浙江省科技进步一等奖[1]2011年当选德国国家科学院院士浙江大学医学部基础医学系来茂德教授于2011年7月当选德国科学院院士。