S.E.M.I. – Side Effects May Include...
Release date: Nov 20, 2025
Developers: Two Horn Unicorn
Publishers: Two Horn Unicorn
Genres: Action, Indie, Early Access
Categories: Single-player, Multi-player, Co-op, Online Co-op, Full controller support, Custom Volume Controls, Playable without Timed Input, Stereo Sound, Surround Sound, Family Sharing
Supported languages: English, Russian, French, German, Spanish - Spain, Simplified Chinese, Portuguese - Brazil, Japanese, Korean

S.E.M.I. is a cooperative online game about escaping from a special clinic. Here, you and up to 3 of your brainless loyal friends play as patients, fighting staff and other patients while stumbling into all sorts of unexpected situations.  Brawls, side-effect pills, and brutal platforming will absolutely challenge your clumsy friends’ hands sense of teamwork.  Expect obstacles, puzzles, deadly traps, and rooms where a single wrong move can knock out the entire squad. Communicate in voice chat and arrange sabotage  help your friends pass through rooms, get out of traps and fight with opponents! In your arsenal: close combat, physics, amazing abilities and ... imagination! Take pills and get abilities : Bipolar force is an invulnerable monster, then a helpless rag! Laser astigmatism — two sights, one laser… Where will he shoot? Stendhal syndrome — are you looking at a painting? Now you're hysterical and destroying everything around you! Alice's syndrome is either tiny or gigantic — have time to adjust! Madness is near! You and your friends can go crazy and start running, jumping and fighting, and your abilities will become uncontrollable. Do you want to take back control? Take the pills :) Locations are randomly generated from rooms with changing gravity, traps, moving walls, and other 'pleasant' surprises. After a successful escape, you will receive a medical report: ' The patient was stable until he started hitting the guards with a bottle. Diagnosis: Overmotivation ' or something worse ! Unlock new costumes and decorations. Let each new escape be more stylish than the previous one! Will you and your friends be able to escape... or at least not go crazy? Welcome to the mental hospital! Here, your abilities are a lottery, and your friends can be the most dangerous opponents!