In the beginning, Columbus is obsessed with making a trip westwards to Asia, but lacks crew and a ship. The Catholic theologians at the University of Salamanca heavily disapprove of it, and they are not keen on ideas that go against the writings of Ptolemaeus. After continuous warnings at the monastery, he becomes involved in a brawl with the monks, ending up lying in the monastery courtyard to pay penance. His eldest son, Diego, one of the monks, looks on disapprovingly. As Columbus continues his penance through a vow of silence, he is approached by Martín Pinzon, a shipowner from Palos, who introduces Columbus to the banker Santángel. Queen Isabella I (Sigourney Weaver) owes money to Santángel. Columbus meets with the queen, who grants him his journey in exchange for his promise to bring back sufficient amounts of riches in gold.
Columbus tricks many crewmen by telling them that the voyage would only last seven weeks. He goes to confession at the monastery to absolve his sins, and the monk reluctantly gives him absolution, as he is unable to inform the crewmen without breaking his oath. The next morning, three ships leave for the trip to Asia, with the flagship being the Santa Maria. During the voyage at night, Captain Méndez notices him navigating by the stars, a skill previously known only to the Moors. Columbus then happily teaches how to use the quadrant to find the North Star and that the 28th parallel must be followed to find land. Nine weeks go by and still no sign of land. The crew becomes restless and the other captain turns against Columbus. He tries to reinvigorate them, to let them see the dream that he wishes to share. While some of the crewmen were still not convinced, the main sail suddenly catches the wind, which the crewmen see as a small act of God's willingness. At night, Columbus notices mosquitoes on the deck, indicating that land is not far off. Some days later, Columbus and the crew spot an albatross flying around the ship, before disappearing. Suddenly, out of the mist they see Guanahani ("San Salvador") with lush vegetation and sandy beaches, the first discovery of the New World.
They befriend the local natives, who show them gold they have collected. Columbus teaches one of them Spanish so that they are able to communicate. He then informs them that they are to return to Spain momentarily to visit the Queen and bring the word of God. They leave behind a group of crewmen to begin the colonisation of the New World. Columbus receives a high Spanish honour from the Queen and has dinner with the Council. They express disappointment with the small amount of gold he brought back, but the Queen approves of his gifts. On the 2nd expedition, Columbus takes 17 ships and 1,500 men with him to the island; however, all the crewmen left behind are found to have been killed. When the tribe is confronted by Columbus and his troops, they tell him that other strangers came and savaged them. Columbus chooses to believe them, but his commanding officer Moxica is not convinced. They begin to build the city of La Isabela and eventually manage to hoist the town bell into its tower, symbolising the arrival of Christianity in the New World.
Four years later, Moxica cuts the hand off one of the natives, accusing him of lying about the whereabouts of gold. The word of this act of violence spreads throughout the native tribes and they all disappear into the forest. Columbus begins to worry about a potential war arising, with the natives heavily outnumbering them. Upon return to his home, he finds his house ablaze by Moxica and his followers, confirming his unpopularity among a certain faction of the settlers. Soon, the tribes arrive to fight the Spaniards and the island becomes war-torn, with Columbus' governorship being reassigned with orders for him to return to Spain.
Christopher Columbus is accused of nepotism and offering administrative positions to his personal friends, thereby injuring the pride of the nobles such as Moxica; so, he is replaced by de Bobadilla. It is revealed that Amerigo Vespucci has already discovered the mainland America. Therefore, Columbus returns to Castile. Columbus is sentenced to many years in prison, but he is bailed out by his sons soon after. When summoned by the Queen about seeing the New World again, he makes a case for her about his dream to see the New World. She agrees to let him take a final voyage, with the proviso that he does not go with his brothers nor returns to Santo Domingo or the other colonies. Columbus and his son go to Panama.The closing scene shows him old, with his youngest son writing down his tales of the New World.

Question: What happened to the group of crew men that Columbus left on San Salvador?
Answer: They were killed by the natives.