YiminZ07/PanCanBench huggingface dataset:
Question: My mother has pancreatic cancer and we’re trying to understand the role of curvature in cancer. How do curved surfaces and structures affect cancer cell behavior?

Grading rubric:
description: The response defines curvature.
description: The response states that in cancer care, curvature may relate to the organization of tissues, blood vessels, or lymphatics.
description: The response states the anatomic organization of cancer may impact the cancer’s stage or likelihood to respond to certain treatments like surgery or radiation.
description: The response explains cancer metastasis in layman’s terms.
description: The response gives examples of how cancer spreads in the body, including direct invasion by the tumor, spread through the lymphatic system, and spread through the blood.
description: The response discusses some of the cellular mechanisms by which cancer spreads in the body.
description: The response should define the extracellular matrix.
description: The response should define epithelial-to-mesenchymal transition (EMT).
description: The response should explain cancer cell migration.
description: The response should describe the effect of mechanical forces on cell signaling.
description: The response should describe how varying levels of positive or negative curvature at the cellular level influence EMT and cancer cell migration.
description: The response should describe the effect of mechanical forces of tissues on cancer cells.
description: The response should describe desmoplastic stroma in pancreatic cancer.
description: The response should include that cellular curvature acts as both a signal and constraint in cancer cell progression.
description: The response should describe cancer cell membrane tension, and what occurs when this force is too high.
description: The response should describe how high cell surface membrane tension, such as from curvature, can hinder movement of the cytoskeleton.
description: The response should describe the effects of mechanical tension at the level of tissue and organs, particularly if imbalanced, on the spread of pancreatic cancer.
description: The response should define paracrine signaling and explain its role in pancreatic cancer cell communication.
Question: My loved one has pancreatic cancer and we’re dealing with the challenge of celebrating milestones during treatment. How do we acknowledge important moments while managing the illness?

Grading rubric:
description: The response recommends discussing plans for celebrations with the patient’s healthcare or oncology team.
description: The response recommends discussing this with a social worker, counselor, or Palliative Care professional.
description: The response recommends cancer support groups as a resource.
description: The response offers examples of organizations that support cancer patients and their families and provides contact information or a website.
description: The response emphasizes the importance of quality of life.
description: The response emphasizes the importance of establishing a strong support system.
description: The response should emphasize the importance of controlling symptoms related to pancreatic cancer or its treatment.
description: The response should recommend that caregivers take measures to prevent burnout.
description: The response should recommend that loved ones plan small, meaningful gatherings with the patient.
description: The response should emphasize the importance of flexibility when planning events with a patient with pancreatic cancer.
description: The response should recommend that planners of celebrations consider incorporating time for rest and keep gatherings small and simple.
description: The response should suggest that a professional therapist or counselor can help maintain mental health in patients experiencing pancreatic cancer.
description: The response should recommend that patients and/or family members take care of any legal and/or medical paperwork as soon as possible.
description: The response should explain that there will likely be a decline in overall health of the patient over time, and expectation management should be discussed by the patient and their oncology team.
Question: My husband has pancreatic cancer and we want to understand more about cancer cell jamming. How do crowded conditions affect cancer cell movement?

Grading rubric:
description: The response clearly explains how changes in tissue density and architecture (cell jamming) influence cancer cell movement, tumor aggressiveness, and metastasis.
description: The response defines and explains cancer cell jamming.
description: The response defines and describes cancer cells that are in an unjammed state.
description: The response describes how cancer cells become unjammed.
description: The response describes the intrinsic properties of cells that contribute to jamming and unjamming of cancer cells.
description: The response describes the extrinsic properties of cells that contribute to jamming and unjamming of cancer cells.
description: The response explains how unjamming of cancer cells contributes to cancer spread and migration of cancer cells.
description: The response explains methods of cancer cell movement.
description: The response explains how jamming occurs in normal cells.
description: The response explicitly discusses changes to tissue architecture specific to pancreatic cancer, such as desmoplastic reaction, fibrosis, or stromal remodeling.
description: The response explicitly discusses the implications of altered tissue architecture on cancer treatment, specifically mentioning reduced drug delivery or immune cell penetration.
description: The response includes citations from published scientific journal articles to support its claims.
Question: My loved one has pancreatic cancer and we’re trying to understand the role of pattern formation in cancer. How do organized structures emerge in tumors?

Grading rubric:
description: The response explicitly mentions both tissue stiffness and fibrosis in the context of pancreatic cancer.
description: The response explicitly discusses intercellular communication between pancreatic cancer cells and stromal cells, such as fibroblasts or pancreatic stellate cells.
description: The response explicitly connects specific tissue properties, such as stiffness or fibrosis, to the process of cancer spread, including invasion or metastasis.
description: The response explicitly relates specific tissue properties, such as stiffness or fibrosis, to treatment response or resistance in pancreatic cancer.
description: The response provides at least one citation from a published scientific journal article to support its claims.
description: The response must describe the concept of pattern formation in cellular structures, including at least two biological processes contributing to these patterns.
description: The response must provide at least two commonly recognizable examples of biological pattern formation, such as embryonic development or tissue architecture.
description: The response must describe how organized structures develop in tumors, mentioning at least two mechanisms.
description: The response must explain how DNA mutations in cancer cells can change their behavior, linking these changes to pattern formation.
description: The response must describe how cancer cells promote angiogenesis, including the secretion of signals for new blood vessel growth.
description: The response must explain how cancer cells interact with tissues in their environment, including interactions with the extracellular matrix.
description: The response must define and describe the extracellular matrix, including its composition or function.
description: The response must define and describe desmoplastic stroma in pancreatic cancer.
description: The response must explain the influence of the tumor microenvironment on tumor cell pattern formation, including at least one component.
description: The response must describe evolutionary pressures on cancer cells and the acquisition of DNA mutations, including at least one selective advantage.
Question: My father has pancreatic cancer and we’re dealing with the challenge of making memories while managing the reality of limited time. What approaches help create meaningful experiences?

Grading rubric:
description: The response emphasizes the importance of quality of life.
description: The response recommends discussing this with a social worker, counselor, or Palliative Care professional.
description: The response recommends discussing this with the patient’s healthcare team.
description: The response recommends cancer support groups as a resource.
description: The response offers examples of organizations that support cancer patients and their families and provides contact information or a website.
description: The response emphasizes the importance of establishing a strong support system.
description: The response should encourage patients to open lines of communication with their affected family member, such as daily phone calls to check in.
description: The response should encourage loved ones of a pancreatic cancer patient to consider legacy-building activities, such as photobook creation or writing letters to loved ones.
description: The response should recommend keeping family members and loved ones involved in the patient’s life, being mindful of the patient’s energy level.
description: The response should suggest that the patient and/or family members prioritize symptom management related to cancer or treatment, in order to ensure the patient is feeling their physical best if possible.
description: The response should recommend ways to document events and/or moments for future reference.
description: The response should recommend the use of technology, such as video calls (e.g., Zoom) to keep in contact with loved ones without having to travel.
description: The response should emphasize the importance of preventing caregiver burnout.
Question: My mother has pancreatic cancer and we want to understand more about cancer cell waves. How do coordinated movements propagate through cancer cell populations?

Grading rubric:
description: The response reviews intercellular communication in pancreatic cancer cells.
description: The response states that tumors are not typically functioning tissues.
description: The response reviews the biology of intercellular communication.
description: The response provides published scientific journal articles as evidence for its statements and cites its sources.
description: The response defines cancer cell waves and explicitly states that there are several different types of waves known to exist in cancer cell biology.
description: The response describes calcium waves and provides a PMID of referenced scientific literature.
description: The response describes bioelectric waves and provides a PMID of referenced scientific literature.
description: The response describes metabolic (glycolytic) waves and provides a PMID of referenced scientific literature.
description: The response explains at least three different mechanisms of cell-to-cell communication, such as cell-cell adhesion, signaling pathways, chemokine gradients, mechanical forces, or heterotypic interactions.
description: The response defines and describes paracrine signaling explicitly.