that you are creating when you are converting fats into ketones beta-hydroxybutyrate these studies show that that inhibits the nlrpNUMBER_TOKEN inflammasome it slows down the activation of that slowing down interleukin-NUMBER_TOKEN beta which is associated with the pain and inflammation that you have with gout so that would make sense that we'd say okay we'll absolutely do the ketogenic diet it's going to solve all your gout problems well again perhaps it can help when it comes down to gout flare-ups and kind of like reduce that perhaps but we also have to remember that most of these nlrpNUMBER_TOKEN inflammasome studies are done on mice and the thing that we have to remember although these are very relevant studies when they're done with mice they are giving mice a very high fat very low protein ketogenic diet so it's very specific because they're trying to induce ketones high levels of ketones the ketones are the anti-inflammatory effect not necessarily the diet itself so then we jump over and we look at the human keto diet and there's nothing wrong with what i'm about to say there's nothing wrong with this kind of diet it's just how we do keto i do it right well we eat a lot more meat than what a mouse would be eating on keto right we're eating high amounts of meat which have high amounts of purines which form uric acid that uric acid forms those urate crystals those urate crystals go into the joint and the uric crystals are in the joint then you have a buildup of macrophages and those macrophages trigger the nlrpNUMBER_TOKEN inflammasome to trigger that that pain that inflammation right so what i'm saying is the root of gout could be like triggered more with keto so you kind of cancel it out right you get this inhibition of nlrpNUMBER_TOKEN inflammasome perhaps you're not getting your ketones high enough to inhibit it but you're also giving your body what causes it right or presumably causes it so how do you kind of combat this well i do think the ketogenic diet could be very powerful for modulating those flare-ups but i think you also have to limit how much protein you're taking in if you're someone that has gout so in this particular case you might want to reduce your protein intake down to like NUMBER_TOKEN percent and the protein that you do get maybe you want to get less from meat sources and more from things like chicken eggs like duck eggs even pea protein things like that you might just have to modify so you're getting less of those purines in especially less in the way of beef so you just make these modifications and additionally i mean i'm not going to go and say that you need to buy a bunch of exogenous ketones but this might be one of those instances where perhaps the use of exogenous ketones can drive up ketone levels a little bit higher and have that nlrpNUMBER_TOKEN sort of inhibition effect i have a lot of issues with taking exogenous ketones so i don't want to just encourage everyone to jump out there and try them but perhaps it's a place for it i think the better avenue is for you to do what you can to drive ketone levels higher now remember ketone levels don't necessarily mean that you're
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