about the same weight until about NUMBER_TOKEN cal NUMBER_TOKEN days in excuse me at about NUMBER_TOKEN days in they started to separate so it's interesting showing that it takes some time for the effects of the fasting mimicking sort of intervention to have an effect in terms of weight but what's really cool is the visceral adipose tissue levels okay the visceral the visceral fat of the mice that did the fasting mimicking were significantly lower okay this is huge because this is metabolically active fat and this is very important when it comes down to just metabolic health but what i get most intrigued about is when they do the gene ontology so they looked at how the genes were reacting okay the mice that did the fasting mimicking ended up having better results in terms of the genes that were associated with metabolic health like mitochondrial efficiency and mitochondrial health so they ended up ultimately metabolically better off from a gene expression standpoint okay they also had better biosynthesis of acetyl coenzyme a which means that they were potentially able to manufacture energy better this is where things get fascinating these sort of things were down regulated in the high fat high calorie group that did not have the fasting intervention so what that is showing is when they're eating about the same diet but just a quick surge of fasting intervention actually ended up making it so their genes were expressing better improving metabolic health now we have to accept that this is in mice and again a disclaimer does not translate into humans especially on the timeline but there are some other studies that volter longo had published before okay the science of translational medicine there was a study where he took a look at humans specifically okay this was interesting because he had humans do a five-day fasting mimicking diet every month for three months had some interesting positive results there he determined that there was a safe reduction in metabolic risk factors in the group that ended up doing the fasting mimicking in this particular study there's an average weight loss of about six pounds in the fasting mimicking group and the overall waist circumference decreased by about one to two inches that's pretty darn cool okay now there are a lot of things that didn't change for example like c reactive protein inflammatory markers didn't really change so yeah you have to ask yourself the question like would this be enough time perhaps the study needed to be you know lengthened out a little bit longer although this is all super fascinating one of the things that we really have to pay attention to is that NUMBER_TOKEN hours of fasting in mice is equal to about a week of fasting in humans okay so we absolutely cannot take the exact data especially in terms of timeline from a mouse study a rodent study into a human model okay because it would simply imply that you're doing the fasting mimicking for over a month okay if you were to actually like extrapolate the timeline over to humans and i don't think that humans should do fasting mimicking diets for a month the protein is simply too low and it wouldn't be good overall for just tissue repair things like that so usually what walter longo like he endorses kind of doing like five day runs of it well a five day run would only be like a NUMBER_TOKEN hour or NUMBER_TOKEN hour kind of fasting experiment in mice so it's not directly translatable but what we can see here is that by kind of having this fasting mimicking approach we might be able to influence our metabolic markers and
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