And when you've got that lag time in between, you shift all sorts of estrogen receptor patterns, and that's where all of the bad effects come from. - Wow! - All of the monkey studies had involved just maintaining ovulatory levels into the post-menopausal period. And you do that and you get great effects. Estrogen is one of the greatest predictors of protection from Alzheimer's disease, all of that, but it needs to be physiological. Just keep continuing what your body has been doing for a long time versus let the whole thing shutdown and suddenly like try to fire up the coal stoves at the bottom of the basement kind of thing, and get that going, there you get utterly different outcomes. And that caused a lot of human health consequences when people suddenly decided that estrogen is in fact neurologically endangering post-menopausally.
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