Molecule ID: 9500

IUPAC Name: 6-aminopyridine-3-carboxamide

Description: The molecule is a monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 6-aminonicotinic acid with ammonia. An inhibitor of the NADP(+)-dependent enzyme, 6-phosphogluconate dehydrogenase, it interferes with glycolysis, resulting in ATP depletion and synergizes with DNA-crosslinking chemotherapy drugs, such as cisplatin, in killing cancer cells. It has a role as a teratogenic agent, an antimetabolite and an EC 1.1.1.44 (NADP(+)-dependent decarboxylating phosphogluconate dehydrogenase) inhibitor. It is an aminopyridine, a primary amino compound and a monocarboxylic acid amide. It derives from a 6-aminonicotinic acid.

SMILES: N=C(O)c1ccc(=N)[nH]c1

SELFIES: [N][=C][Branch1][C][O][C][C][=C][C][=Branch1][C][=N][NH1][C][=Ring1][#Branch1]

InChI: InChI=1S/C6H7N3O/c7-5-2-1-4(3-9-5)6(8)10/h1-3H,(H2,7,9)(H2,8,10)

Molecular Properties:
- Polar Surface Area: 82.0 Ų
- LogP: 0.7