context: Editor's note: This article was updated on August 6, 2018. The black-legged tick is on the move. Cases of Lyme disease -- traditionally more prevalent in the Northeast -- have now been found in all 50 states and the District of Columbia, a new study from Quest Diagnostics found. While the Northeast still reported the highest number of cases, California and Florida had the highest precentage increase in positive test results from 2015 to 2017. Experts say the tick has been expanding ts range into the southern and western U. S. and into Canada, making it likely that the number of Lyme disease cases in North America will climb. A recent CDC study found that cases of Lyme increased more than 80% between 2004 and 2016 -- from 19,804 to 36,429. Those are the reported cases. The CDC estimates there are more than 300,000 cases of Lyme infection in the U. S. each year -- or 10 times as many as what is reported. â There's obviously year-to-year bouncing around, but the trend line is upward,â says John Aucott, MD, director of the Johns Hopkins Lyme Disease Clinical Research Center in Baltimore. â It won't stop in the foreseeable future.â Most cases are clustered in 14 states in the Northeast and Upper Midwest, but Lyme has been reported as far south as Mexico, and increasingly, in Canada. The black-legged tick ( Ixodes scapularis), also known as the deer tick, carries the bacteria that causes Lyme infection. The same tick also can spread other diseases, including babesiosis, anaplasmosis, and Powassan virus -- other diseases on the rise in the U. S. Here's more about the disease and what to expect this year and beyond. Lyme disease is caused by bacteria, Borrelia burgdorferi that are transmitted to humans through a bite from an infected black-legged or deer tick. Symptoms can occur anywhere from 3 to 30 days after the bite and can be wide-ranging, depending on the stage of the infection. In some cases, symptoms can appear months after the bite. The chances you might get Lyme disease from a tick bite depend on the kind of tick, where you were when the bite occurred, and how long the tick was attached to you, the CDC says. Black-legged ticks must be attached to you for 36 to 48 hours to transmit Lyme disease. If you remove the tick or ticks within 48 hours, you aren't likely to get infected, says Cleveland Clinic infectious disease specialist Alan Taege, MD. Early signs and symptoms include fever, chills, headache, fatigue, muscle and joint pain, and swollen lymph nodes -- all common in the flu. In up to 80% of Lyme infections, a rash is one of the first symptoms, Aucott says. Without treatment, symptoms can progress. They might include: Severe headache or neck stiffness Rashes on other areas of the body Arthritis with severe joint pain and swelling, particularly in the knees Loss of muscle tone or âdroopingâ on one or both sides of the face. Heart palpitation or an irregular heartbeat Inflammation of the brain and spinal cord Shooting pains, numbness, or tingling in the hands or feet About 20% to 30% of Lyme rashes have a âbull's-eyeâ appearance -- concentric circles around a center point -- but most are round and uniformly red and at least 5 centimeters (about 2 inches) across, Aucott says. â Most are just red,â he says. â They do not have the classic ring within a ring like the Target logo.â The rash expands gradually over a period of days and can grow to about 12 inches across, the CDC says. It may feel warm to the touch, but it rarely itches or is painful, and it can appear on any part of the body. Ticks can be the size of a poppy seed. Can you spot all 5 ticks in this photo? Learn how to prevent tick bites. https://t.co/ ATtr Y7 YFo S pic.twitter.com/g Bm4tw2qmf â CDC (@ CDCgov) May 4, 2018 TIcks come in three sizes, depending on their stage of life. Larvae are the size of grains of sand, nymphs the size of poppy seeds, and adults the size of an apple seed. Doctors diagnose it based on symptoms and a history of tick exposure. Two-step blood tests are helpful if used correctly. But the accuracy of the test depends on when you got infected. In the first few weeks of infection, the test may be negative, as antibodies take a few weeks to develop. Tests aren't recommended for patients who don't have Lyme disease symptoms. Aucott says the most promising development in the fight against Lyme disease are better diagnostic tests that are accurate in the first few weeks after exposure. The earlier the treatment, the less likely the disease will progress. Aucott says he expects the tests to be available soon. Doctors may not recognize symptoms, especially those who practice in areas where Lyme infection isn't prevalent, and up to 30% of the infections are not accompanied by a rash. There are three stages: Early localized Lyme: Flu-like symptoms such as fever, chills, headache, swollen lymph nodes, sore throat, and typically a rash that has a âbull's-eyeâ appearance or is uniformly round and red and at least 5 centimeters in size Early disseminated Lyme: Flu-like symptoms that now include pain, weaknessor numbness in the arms and legs, vision changes, heart palpitations and chest pain, a rash, and facial paralysis ( Bell's palsy) Late disseminated Lyme: This can occur weeks, months, or years after the tick bite. Symptoms might include arthritis, severe fatigue and headaches, vertigo, sleep disturbances, and mental confusion. While experts don't understand it, roughly 10% of people treated for Lyme infection do not shake the disease. They may go on to have three core symptoms -- joint or muscle pain, fatigue, and short-term memory loss or mental confusion This is called post-treatment Lyme disease syndrome. It's considered controversial because its symptoms are shared with other diseases and there isn't a blood test to diagnose it, Aucott says. There are theories as to why Lyme symptoms become chronic. One is that the body continues fighting the infection long after the bacteria are gone, much like an autoimmune disorder. Antibiotics are used to treat early stage Lyme infection. Patients typically take doxycycline for 10 days to 3 weeks, or amoxicillin and cefuroxime for 2 to 3 weeks. In var ia Module Data = ia Module Data || []; ia Module Data.push({ type: ' Slideshow', id: 'ia-slideshow-2', position: 'left', title: ' Lyme Disease Slideshow', description: ' Web MD\'s Lyme Disease Slideshow provides up-close pictures of Lyme disease rashes and the ticks that can carry the disease, along with information on symptoms at each stage of the disease, the diagnostic testing used, common treatments, and essential prevention measures. ', chronicle Id: '091e9c5e80336e0c', share: { suppress: false, title: ' Lyme Disease Slideshow', description: ' Web MD\'s Lyme Disease Slideshow provides up-close pictures of Lyme disease rashes and the ticks that can carry the disease, along with information on symptoms at each stage of the disease, the diagnostic testing used, common treatments, and essential prevention measures. ', url: 'www.webmd.com/rheumatoid-arthritis/arthritis-lyme-disease', image: 'https://img.webmd.com/dtmcms/live/webmd/consumer_assets/site_images/article_thumbnails/slideshows/lyme_disease/69x75_lyme_disease.jpg', } }); window.webmd Carousel Promise = window.webmd Carousel Promise || $. Deferred(); $(function() { require(['ia-modules/1/ia-modules.min','webmd.carousel/1/webmd.carousel.min','webmd.oauth/1/webmd.oauth'], function(ia M, carousel, oauth){ window.webmd Carousel Promise.resolve(carousel, oauth); }); }); up to 90% of cases, the antibiotic cures the infection. If it doesn't, patients might get other antibiotics either by mouth or intravenously. For early disseminated Lyme disease, which may happen when a Lyme infection goes untreated, oral antibiotics are recommended for symptoms such as facial palsy and abnormal heart rhythm. Intravenous antibiotics are recommended if a person has meningitis, inflammation of the lining of the brain and spinal cord, or more severe heart problems. In late-stage Lyme, a patient may receive oral or intravenous antibiotics. Patients with lingering arthritis would receive standard arthritis treatment. There is no treatment for post-treatment Lyme disease syndrome. â Ten percent of people don't get better after antibiotics,â Aucott says. â We think it's very significant if 30,000 people a year don't get better.â Mainly New England, the Mid- Atlantic states, and part of the Upper Midwest. The CDC says 95% of confirmed cases in 2016 were in 14 states: Connecticut, Delaware, Maine, Maryland, Massachusetts, Minnesota, New Hampshire, New Jersey, New York, Pennsylvania, Rhode Island, Vermont, Virginia, and Wisconsin. From 2006 to 2016, case numbers have increased in Ohio, Indiana, and Michigan as the tick's range expands westward. var ia Module Data = ia Module Data || []; ia Module Data.push({ type: ' Video', id: 'ia-video-3', position: 'left', mode: 'interactive', video: { chronicle ID: '091e9c5e8172b18a', title: ' How to Remove a Tick', description: ' Most tick bites aren\'t an issue if you discover them shortly after time spent outdoors. How do you remove one, and what symptoms should you talk to your doctor about? ', }, share: { suppress: false, title: ' Most tick bites aren\'t an issue if you discover them shortly after time spent outdoors. How do you remove one, and what symptoms should you talk to your doctor about? ', url: 'www.webmd.com/rheumatoid-arthritis/arthritis-lyme-disease', } }); window.webmd Video Promise = window.webmd Video Promise || $. Deferred(); $(function() { require(['ia-modules/1/ia-modules.min','video2/1/responsive-player/video-loader','webmd.oauth/1/webmd.oauth'], function(ia M, video Loader, oauth){ window.webmd Video Promise.resolve(video Loader, oauth); }); }); In 2016, the highest number of confirmed Lyme infection cases -- 9,000 -- was reported in Pennsylvania, followed by New Jersey, with more than 3,300 cases. In the Southern U. S., which is more prone to hot weather, ticks tend to stay under leaf litter and don't come up higher to feed much, Aucott says -- âticks don't like to dry out.â This means Southern ticks don't transmit Lyme as frequently because they don't tend to feed on humans. Infection is more common in males up to age 15 and between the ages of 40 and 60, says Taege. â These are people who are more likely to play outside, and go camping, hunting, and hiking,â he says. Aucott adds that Lyme infection drops off in older teens and those in their 20s âbecause they're inside on their computers.â Older adults, he says, tend to have more time to work in their backyards, which is where most Lyme infection is transmitted. Scientists point to a variety of causes for the spread of Lyme infection. Among them are reforestation, especially in the Northeast U. S., where Lyme disease is more prevalent; climate change and temperature extremes; suburbanization; and more exposure to the white-tailed deer, which is the black-legged tick's favorite mode of travel. var ia Module Data = ia Module Data || []; ia Module Data.push({ type: ' Image', id: 'ia-image-4', position: 'left', image: { url: 'https://img.webmd.com/dtmcms/live/webmd/consumer_assets/site_images/article_thumbnails/slideshows/guide_to_tick_borne_diseases_slideshow/650x350_guide_to_tick_borne_diseases_slideshow.jpg', alt: '' }, caption: { header: '', description: ' A tick in action.' }, share: { suppress: true, title: '', description: ' A tick in action. ', url: 'www.webmd.com/rheumatoid-arthritis/arthritis-lyme-disease', image: 'https://img.webmd.com/dtmcms/live/webmd/consumer_assets/site_images/article_thumbnails/slideshows/guide_to_tick_borne_diseases_slideshow/650x350_guide_to_tick_borne_diseases_slideshow.jpg', } }); require(['ia-modules/1/ia-modules.min']); Development led to record low numbers of deer early in the last century, says CDC epidemiologist Paul Mead, MD. But the deer population has rebounded as reforestation took place over several decades, meaning the tick population has risen and expanded as well. â Ticks have a pretty long life cycle, lasting 2-3 years, and typically don't move very far within their lifetime, so it takes a while to see large changes,â he says. Deer and white-footed mice, which transmit Lyme disease to ticks that bite them, are moving closer to humans as their habitats disappear, says Taege. Ticks don't mind dogs, either, which carry them into homes and spread them to their humans. Another reason: Warmer weather and mild winters may bring more people outside, raising their chances of being bitten, particularly in Lyme-prone areas, Taege says. â Whether you believe in global warming or not, we have longer, warmer summer months, and people are outdoors more,â says Taege. â We've seen an expansion [of ticks] in areas in which the vectors live, and we've slowly seen more Lyme disease.â That doesn't mean you should be afraid of outdoor activities, as long as you take precautions to avoid tick bites, Aucott says. Ticks can't fly or jump, but instead live in shrubs and bushes, and grab onto someone when they pass by. To avoid getting bitten: Wear pants and socks in the woods, areas with lots of trees, and while handling fallen leaves Wear a tick repellent on your skin and clothing that has DEET, lemon oil, or eucalyptus. For even more protection, use the chemical permethrin on clothing and camping gear. Shower within 2 hours after coming inside, if possible. Look at your skin and wash ticks out of your hair. Put your clothing and any exposed gear into a hot dryer to kill whatever pests might remain. Given that the ticks are the size of a poppy seed, you've got to have pretty good eyes. The CDC recommends that if you've been walking in the woods, in tall grass, or working in the garden, check your skin afterward, ideally in the shower or bath. That way, you've removed your clothes, which may carry ticks, too. Remove it with a pair of fine-tipped tweezers as soon as possible, pulling upward with steady pressure. If parts of the tick remain in the skin, also try to remove them with the tweezers. After everything is out, clean the bite area with rubbing alcohol or soap and water. Mead says you're not likely to get infected if you remove the tick within 36 to 48 hours. Some people have an allergic reaction to ticks, so they'll notice a bite right away. Place it in soapy water or alcohol, stick it to a piece of tape, or flush it down the toilet. The rash is a pretty good indication that you may have been bitten. Take a photo of the rash and see your doctor, Aucott says. At this stage of the illness, treatment with antibiotics will probably be successful. If you don't have the telltale rash but have a summer flu -- fatigue, fever, headache but no respiratory symptoms like a cough -- you may want to talk to your doctor, Aucott says. The FDA in July 2017 gave "fast-track" approval to French biotech company Valneva to test potential Lyme disease vaccine VLA15 on adults in the U. S. and Europe. Data from the first phase are expected to be released soon, and then the second phase will begin. The more ticks in your region, the likelier it is that your furry pal will bring them home. Mead says. var ia Module Data = ia Module Data || []; ia Module Data.push({ type: ' Image', id: 'ia-image-5', position: 'left', image: { url: 'https://img.webmd.com/dtmcms/live/webmd/consumer_assets/site_images/article_thumbnails/video/how_to_remove_a_tick_from_your_pet_video/650x350_how_to_remove_a_tick_from_your_pet_video.jpg', alt: '' }, caption: { header: '', description: ' A dog owner looks for ticks on his pet.' }, share: { suppress: true, title: '', description: ' A dog owner looks for ticks on his pet. ', url: 'www.webmd.com/rheumatoid-arthritis/arthritis-lyme-disease', image: 'https://img.webmd.com/dtmcms/live/webmd/consumer_assets/site_images/article_thumbnails/video/how_to_remove_a_tick_from_your_pet_video/650x350_how_to_remove_a_tick_from_your_pet_video.jpg', } }); require(['ia-modules/1/ia-modules.min']); Dogs are much more likely than humans to be bitten by ticks, and where Lyme disease is more prevalent, up to 25% of dogs have evidence of past infection, he says. â On the flip side, low rates of exposure in dogs is a good indicator that Lyme is not a problem in the area.â And they can get sick. About 10% of dogs with Lyme disease will become ill. Common symptoms, which may show up 7-21 days after a tick bite, are lameness -- your dog will appear to be walking on eggshells -- a fever, lethargy, and enlarged lymph nodes. Dogs also get antibiotics for treatment. Practice prevention habits and use a tick control product on your pet. A Lyme vaccine is also available for dogs.