VictorJuiz/thesis huggingface dataset:
Effects of Acute Periods of Prenatal Stress on Behaviour and Endocrine Function in Guinea Pigs

Epidemiological studies in humans have revealed a relationship between altered development in utero and an increased incidence of pathophysiology during postnatal life. One of the mechanisms underlying this relationship is thought to be exposure to excess glucocorticoids during critical phases of brain development. The aim of the current set of studies was to determine the effects of prenatal stress during discrete developmental windows on behaviour and endocrine function in male and female guinea pig offspring. Guinea pigs were used as the model for these studies as they are a long-gestation species that give birth to neuroanatomically mature young and fetal brain development is well characterized. Pregnant guinea pigs were exposed to a high frequency strobe light during the period of rapid fetal brain growth or the period of rapid brain myelination. Pregnant guinea pigs were allowed to deliver normally and guinea pig offspring were tested for ambulatory activity, anxiety and hypothalamic-pituitary-adrenal (HPA) axis function. Male offspring whose mothers were exposed to stress during the period of rapid brain growth exhibited increased anxiety behaviour, increased basal plasma cortisol levels and decreased plasma testosterone levels. We found that replacing testosterone in these animals reversed the behavioural and endocrine differences. Male offspring whose mothers were exposed to stress during the period of rapid myelination exhibited an increased plasma cortisol response to activation of the HPA axis. Female offspring whose mothers were exposed to stress during the period of rapid brain myelination exhibited decreased ambulatory activity and a blunted salivary cortisol response to the stress of the strobe light, but only during the estrous phase of the reproductive cycle. Therefore, the current set of studies has demonstrated the effects of prenatal stress on behaviour and HPA axis activity are dependent on; 1) the timing of the prenatal stress and 2) the hypothalamic-pituitary-gonadal axis in both male and female offspring. These studies have begun to uncover the mechanisms underlying programming and provide the basis for continuing research in humans.

Keywords: Prenatal Stress
Programming
HPA Axis
Guinea Pigs
Advisor: Matthews, Stephen
Cultures of Border Control: Schengen and the Evolution of Europe's Frontiers

The dissertation examines one of the most remarkable and controversial developments in the recent history of European integration, namely the institutionalization of a regional policy regime to manage the continent’s frontiers. By adopting this regime (known in policy circles as ‘Schengen’), European governments have in fact relinquished part of their sovereign authority over the politically sensitive issue of border control, thereby challenging what for a long time was the dominant national approach to policy-making in this domain. In order to account for the regime’s emergence and success, a constructivist analytical framework centred on the notion of ‘cultures of border control’ is advanced. From this perspective, the adoption of a regional approach to govern Europe’s frontiers is the result of the evolution of a nationalist (‘Westphalian’) culture—or set of background assumptions and related practices about borders shared by a given policy community—into a post-nationalist one (‘Schengen’). The cultural evolutionary argument elaborated in the dissertation captures the unique political dynamics that have characterized border control in Europe in the last two decades and offers a more nuanced account of recent developments than those available in the existing European Studies literature. It can also shed light on current trends defining European politics beyond border control (e.g., Europe’s policy towards its neighbours) and on other attempts to regionalize border control outside Europe (e.g., the proposal for a North American security perimeter).

Keywords: border control
Schengen
Europe
evolution
culture
Advisor: Adler, Emanuel
Bernstein, Steven Franklin
Hansen, Randall
Security Community in and through Practice: The Power Politics of Russia-NATO Diplomacy

How do security communities develop in and through practice? For more than forty years, security relations between Russia and NATO member states were structured by the spectre of mutual assured destruction as symbolized by thousands of nuclear missiles targeted at each other. Less than a generation after the end of the Cold War, the possibility of military confrontation between these former enemies has considerably receded. Taking inspiration from Pierre Bourdieu, this dissertation develops a theory of practice of security communities that argues that on the ground of international politics, the social fact of peace emerges when security practitioners come to debate with diplomacy—the non-violent settlement of disputes—instead of about diplomacy. It is doxa, a relationship of immediate adherence to the order of things, that makes such a peaceful practical sense possible. In the empirical analysis, the dissertation reveals an intriguing paradox in the post-Cold War Russian-Atlantic relationship. On the one hand, over the last fifteen years Russia and NATO member states have solved each and every one of their disputes, including fierce ones over the double enlargement, by nonviolent means. Such a track record of peaceful change is testimony to security-communitybuilding processes. But on the other hand, diplomatic success was often bought at the price of a growing mistrust on the Russian side. As the Russian Great Power habitus resurfaced, hysteresis—a disconnect between players’ dispositions and their positions in the game—steadily increased to the point of inconclusive symbolic power struggles over the rules of the international security game and the roles that each player should play. A decade and a half after the end of the Cold War, Russian-Atlantic relations have left the terrain of military confrontation but have yet to settle on that of mature peace. Building on several dozen interviews with Russian and NATO security practitioners, the dissertation discovers that diplomacy has become a normal though not a self-evident practice in Russian-Atlantic dealings.

Keywords: Practice theory
Security communities
Russia
NATO
Advisor: Adler, Emanuel
Federalism From Below? The Emergence of Aboriginal Multilevel Governance in Canada. A Comparison of the James Bay Crees and Kahnawa:ke Mohawks

Using the language of rights and national self-determination, Aboriginal peoples have mounted a fundamental challenge to Canadian federalism in the past forty years. In order to move beyond the imposed structure of colonial governance, Aboriginal peoples have sought to establish their own form of federal relationship with contemporary Canadian governments and society. While much attention has been devoted to the constitutional and legal dimensions of Aboriginal challenges to state authority, this thesis argues that incremental yet fundamental changes are also taking place in the less visible but nonetheless important arena of policy-making. Aboriginal claims for greater political recognition, combined with the redefinition of the role of the state associated with neoliberal ideas, have led to the emergence of multilevel governance practices between Aboriginal governing authorities and their federal and provincial counterparts. While they do not alter the formal nature of state authority as defined in the constitution, multilevel policy exercises are characterized by growing interdependencies between Aboriginal and non-Aboriginal governing actors, leading to a partial displacement of formal rules of authoritative decision-making in favor of joint decision-making processes and negotiated solutions to policy disputes. Building on comparative analyses of the transformations in the governance regimes of the James Bay Crees and Kahnawa:ke Mohawks, this thesis argues that these multilevel exercises can become transformative spaces for Aboriginal peoples to reshape their relationship with the state and establish themselves as representatives of distinct political communities with their own sources of authority and legitimacy independent of federal and provincial parliaments. As a result, I argue a new form of federalism may well be emerging not through constitutional negotiations or treaty-making exercises, but from below, in everyday practices of governance.

Keywords: Canada
Politics
Federalism
Indigenous Peoples
Governance
Kahnawake
James Bay Crees
Advisor: Simeon, Richard
Contesting Cosmopolitan Europe: A Study of Non-governmental Organizations in the European Union's External Trade Policymaking Process

This thesis investigates whether more open trade policymaking processes that include non-governmental entities, by virtue of the divergence of interests represented, lead to a stronger, more legitimate and qualitatively enhanced international trade system. The European Union stands out among major trading powers for its significant and dramatic response to new demands for access and participation. The thesis examines whether improvements in the political opportunity structure for ‘progressive’ Non-Governmental Organizations (NGOs) result in more legitimate external trade policymaking in the European Union (EU). Legitimacy is assessed along two lines: the way policy is made (procedural legitimacy) and the projected outcomes of policy (substantive legitimacy). The role of NGOs is evaluated in two important cases in the context of World Trade Organization negotiations since 2000. The first concerns the formulation of the formal European Communities’ (EC) position on trade related intellectual property rights (TRIPS) and access to medicines. The second concerns the EC’s requests for water services liberalization in the context of General Agreement on Trade in Services (GATS) 2000 negotiations. Through a critical evaluation of the role of NGOs in these cases, the thesis argues that there is clear potential for NGOs to represent citizens’ demands, constitute a basic form of popular representation and hold decision-makers accountable to a broader public. However, they cannot determine policy outcomes in this arena. This thesis challenges a theoretical perspective on public policymaking called Cosmopolitanism. Grounded in democratic and normative theory, it conceives of Global Civil Society, and NGOs in particular, as major conduits for democracy and social justice in global and/or regional governance. The thesis builds upon the insights of Constructivism to advance an alternative account of the significance of NGOs in the EU’s external trade policymaking process. In particular, it argues that epistemes, the deepest level of the ideational world, dominate the external trade policymaking process. NGOs succeed only when their attempts to achieve more democratic, just, equitable and fair external trade policies in the EU conform broadly to the dominant legal/liberal episteme. When they seek to overrule that episteme, they fail, regardless of their formal involvement in the external trade policymaking process.

Keywords: European Union
NGOs
Legitimacy
Post-National Governance
Trade Policymaking
WTO
Advisor: Pauly, Louis
BLAST: A Balloon-borne, Large-aperture, Submillimetre Telescope

BLAST is a balloon-borne large-aperture, submillimetre telescope, which makes large area (1-200 square degree) surveys of Galactic and extragalactic targets. Since BLAST observes in the stratosphere, it is able to make broad-band observations between 200um and 550um which are difficult or impossible to perform from the ground. BLAST has been designed to probe star formation both in the local Galaxy and in the high redshift (z=1-4) universe. Because BLAST is flown on an unmanned stratospheric balloon platform, it has been designed to be able to operate autonomously, without needing operator intervention to perform its scientific goals. This thesis includes an overview of the design of the BLAST platform, with emphasis on the command and control systems used to operate the telescope. BLAST has been flown on two long-duration balloon flights. The first of these, from Esrange, Sweden in June of 2005, acquired ~70 hours of primarily Galactic data. During the second flight, from Willy Field, Antarctica in December of 2006, BLAST acquired ~225 hours of both Galactic and extragalactic data. Operational performance of the platform during these two flights is reviewed, with the goal of providing insight on how future flights can be improved. Reduction of the data acquired by these large-format bolometer arrays is a challenging procedure, and techniques developed for BLAST data reduction are reviewed. The ultimate goal of this reduction is the generation of high quality astronomical maps which can be used for subsequent portions of data analysis. This thesis treats, in detail, the iterative, maximum likelihood map maker developed for BLAST. Results of simulations performed on the map maker to characterise its ability to reconstruct astronomical signals are presented. Finally, astronomical maps produced by this map maker using real data acquired by BLAST are presented, with a discussion on non-physical map pathologies resulting from the data reduction pipeline and map making procedures.

Keywords: submillimetre
instrumentation
astrophysics
Advisor: Netterfield, Calvin Barth
Assessment of Trace Gas Observations from the Toronto Atmospheric Observatory

A high-resolution infrared Fourier Transform Spectrometer (FTS) has been operational at the Toronto Atmospheric Observatory (TAO)since May 2002. An optimal estimation retrieval technique is used to analyse the observed spectra and provide regular total and partial column measurements of trace gases in the troposphere and stratosphere as part of the Network for the Detection of Atmospheric Composition Change. The quality of these results were assessed through two ground-based validation campaigns, comparisons with three satellite instruments, and comparison with a three-dimensional chemical transport model. The two ground-based campaigns involved two lower-resolution FTS instruments: the University of Toronto FTS and the Portable Atmospheric Research Interferometric Spectrometer for the Infrared. The first campaign took place over the course of four months and is the longest side-by-side intercomparison of ground-based FTS instruments, to date. The second campaign was more focused and involved all three instruments measuring over a two-week period. Simultaneous measurements of O3, HCl, N2O, and CH4 were recorded and average total column differences were all < 3.7% in the extended campaign, and < 4.5% in the focused campaign. Satellite-based comparisons were done with the SCanning and Imaging Absorption spectroMeter for Atmospheric CHartographY (SCIAMACHY), the Atmospheric Chemistry Experiment Fourier Transform Spectrometer (ACE-FTS), and the Optical Spectrograph and InfraRed Imager System (OSIRIS). Total column CO, CH4, and N2O compared with SCIAMACHY all had average differences < 10% with results from the TAO-FTS being as good as, or better, than that of other instruments. Validation with the ACE-FTS showed that average partial columns of O3, NO2, N2O, CH4, and HCl were within 10% while observations of CO and NO each had an average bias of about 25%. Comparisons of monthly average partial column O3 and NO2 with OSIRIS were highly correlated (R = 0.82-0.97) with monthly mean differences of < 3.1% for O3 and < 2.6% for NO2. Finally, comparisons with the GEOS-Chem chemical transport model revealed that the model consistently over-estimates tropospheric columns of CO and C2H6 observed at TAO. It was determined that the enhanced CO values were partially due to the North American emissions specified in the model, but more work must be done in the future if the source of this discrepancy is to be fully explained.

Keywords: Fourier Transform Spectroscopy
Infrared Spectroscopy
Remote Sensing
Atmospheric Trace Gases
Satellite Validation
Inverse Theory
Advisor: Strong, Kimberly
Dissipation and Decoherence in Open Nonequilibrium Electronic Systems

We theoretically study steady-state nonequilibrium properties of various open electronic systems subject to time-independent external bias. A charge current is established across each system by its coupling to two external particle reservoirs maintained at different chemical potentials. We discuss the impact of intra-reservoir electron correlations on transport, and examine how reservoir-generated dissipation and nonequilibrium-induced decoherence influence these systems. The effect of intra-lead electron interactions on transport is investigated in the context of a phonon-coupled single molecule transistor driven by Luttinger-liquid source and drain leads. The semi-classical master equation approach is used to compute current and noise characteristics of the device for various interaction strengths in the leads. The results suggest the possibility of tuning the Fano factor of the device using intra-lead electron interactions. The Keldysh path integral formalism is used to theoretically formulate models that describe the remaining open nonequilibrium systems. We consider voltage-induced electron-phonon scattering and electron mass enhancement due to phonons in a model metallic system. The possibility of adjusting the acoustic phonon velocity and the Thomas-Fermi screening length with external voltage is discussed. The effects of dissipation is investigated in an open BCS superconducting graphene, where the dissipation-induced rearrangement of its ground state from the BCS superconductor to the Fermi liquid is examined. The results theoretically infer prospects for a voltage-tuned metal-to-BCS quantum phase transition in graphene. Lastly, we develop a theory of nonequilibrium quantum criticality in open itinerant Ising and Heisenberg magnets. Both departures from equilibrium at conventional quantum critical points and the physics of phase transitions induced by the nonequilibrium drive are analyzed.

Keywords: Nonequilibrium
Dissipation
Decoherence
Electronic systems
Advisor: Kim, Yong Baek
Deal? Or No Deal? Explaining Comprehensive Land Claims Negotiation Outcomes in Canada

In 1973, the Canadian government created the federal comprehensive land claims process to negotiate modern treaties with Aboriginal peoples in Canada. Despite 35 years of negotiations, many Aboriginal groups have failed to complete modern treaties. This dissertation explains why some Aboriginal groups have been able to complete modern treaties and why some have not. After examining four sets of negotiations in Newfoundland and Labrador and the Yukon Territory, I argue that scholars need to pay greater attention to the institutional framework governing treaty negotiations and to a number of factors relative to the Aboriginal groups.

Keywords: Political Science
General
Advisor: White, Graham
Quantum Cryptography: From Theory to Practice

Quantum cryptography or quantum key distribution (QKD) applies fundamental laws of quantum physics to guarantee secure communication. The security of quantum cryptography was proven in the last decade. Many security analyses are based on the assumption that QKD system components are idealized. In practice, inevitable device imperfections may compromise security unless these imperfections are well investigated. A highly attenuated laser pulse which gives a weak coherent state is widely used in QKD experiments. A weak coherent state has multi-photon components, which opens up a security loophole to the sophisticated eavesdropper. With a small adjustment of the hardware, we will prove that the decoy state method can close this loophole and substantially improve the QKD performance. We also propose a few practical decoy state protocols, study statistical fluctuations and perform experimental demonstrations. Moreover, we will apply the methods from entanglement distillation protocols based on two-way classical communication to improve the decoy state QKD performance. Furthermore, we study the decoy state methods for other single photon sources, such as triggering parametric down-conversion (PDC) source. Note that our work, decoy state protocol, has attracted a lot of scientific and media interest. The decoy state QKD becomes a standard technique for prepare-and-measure QKD schemes. Aside from single-photon-based QKD schemes, there is another type of scheme based on entangled photon sources. A PDC source is commonly used as an entangled photon source. We propose a model and post-processing scheme for the entanglement-based QKD with a PDC source. Although the model is proposed to study the entanglement-based QKD, we emphasize that our generic model may also be useful for other non-QKD experiments involving a PDC source. By simulating a real PDC experiment, we show that the entanglement-based QKD can achieve longer maximal secure distance than the single-photon-based QKD schemes. We propose a time-shift attack that exploits the efficiency mismatch of two single photon detectors in a QKD system. This eavesdropping strategy can be realized by current technology. We will also discuss counter measures against the attack and study the security of a QKD system with efficiency mismatch detectors.

Keywords: Quantum
Cryptography
QKD
Decoy
Advisor: Lo, Hoi-Kwong
Arctic and Midlatitude Stratospheric Trace Gas Measurements Using Ground-based UV-visible Spectroscopy

A ground-based, zenith-sky, UV-visible triple grating spectrometer was installed at the Polar Environment Atmospheric Research Laboratory (PEARL) in the Canadian High Arctic during polar springtime from 2004 to 2007 as part of the Canadian Arctic ACE (Atmospheric Chemistry Experiment) Validation Campaigns. From the solar spectra, ozone, NO2, and BrO vertical column densities (VCDs) have been retrieved using the DOAS (Differential Optical Absorption Spectroscopy) technique. This spectrometer, the UT-GBS (University of Toronto Ground-Based Spectrometer), was also deployed as part of the fourth Middle Atmosphere Nitrogen TRend Assessment (MANTRA) campaign in Vanscoy, Saskatchewan in August and September 2004. A near-identical spectrometer, the PEARL-GBS, was permanently installed at PEARL in August 2006 as part of the refurbishment of the laboratory by CANDAC (Canadian Network for the Detection of Atmospheric Change). Since then, the instrument has been making continuous measurements, with the exception of during polar night. Vertical columns of ozone and NO2 can be retrieved year-round. During the 2007 sunrise campaign, differential slant column densities (DSCDs) of OClO and VCDs of BrO were also retrieved. Ozone and NO2 DSCDs and VCDs from the UT-GBS were compared to the DSCDs and VCDs from three other UV-visible, ground-based, grating spectrometers that also participated in the MANTRA and Eureka campaigns. Two methods developed by the UV-visible Working Group of the NDACC (Network for the Detection of Atmospheric Composition Change) were followed. During MANTRA, the instruments were found to partially meet the NDACC standards. The comparisons from Eureka were an improvement on the MANTRA comparisons, and also partially met the NDACC standards. In 2007, the columns from the UT-GBS and PEARL-GBS were compared, and were found to agree within the NDACC standards for both species. Ozone and NO2 VCDs from the ground-based instruments were also compared to integrated partial columns from the ACE-FTS (ACE-Fourier Transform Spectrometer) and ACE-MAESTRO (ACE-Measurements of Aerosol Extinction in the Stratosphere and Troposphere Retrieved by Occultation) on board the ACE satellite. ACE-FTS partial columns were found to agree with the ground-based total columns, while the ACE-MAESTRO partial columns were found to be smaller than expected for ozone and larger than expected for NO2.

Keywords: UV-visible spectroscopy
ozone depletion
Arctic
NO2
Advisor: Strong, Kimberly