VictorJuiz/thesis huggingface dataset:
First principles in Aristotle's psychology: the science of soul in De Anima 1

This thesis analyses the method, purpose, and results of Aristotle's treatment of a select number of Presocratic and Platonic theses about the soul within the context of De Anima 1. Contrary to a prevalent interpretation of De Anima 1 which sees Aristotle's treatment of his predecessors' psychological views as dialectical, I argue that Aristotle treats his predecessors as having offered potentially viable hypotheses about the nature of the soul, and that these hypotheses are treated as attempts to explain the soul's basic powers. I further show that, in order to test the explanatory limits of these theories, Aristotle uses a version of the scientific method of inquiry advertised in the Prior and Posterior Analytics, which consists in setting out the basic psychological phenomena which psychology should explain, and then testing the extent to which his predecessors' definitions of the soul are able to accomplish this task. This thesis argues that, by demonstrating where his predecessors' first principles fall short, Aristotle is able to make theoretical progress towards establishing his own 'hylomorphic' first principle of soul, that soul is the 'first fulfilment of a natural instrumental body', and towards the idea that soul operates in the body of living beings as a formal, final, and efficient cause.

Keywords: inquiry
mind
dialectic
science
demonstration
predecessors
soul
Advisor: Johanson, T
Judson, L
The basis of genetic rearrangements in mupirocin resistance plasmids

Staphylococcus aureus is a Gram positive potentially pathogenic bacterium which has a propensity to gather resistance determinants. Mupirocin is a novel topical antibiotic active against many Gram positive species, including staphylococci and effective in the treatment and prevention of staphylococcal infections. Mupirocin acts by competitively inhibiting the charging of isoleucyl tRNA-synthetase (IRS) with isoleucine. Resistance has been observed in Staphylococcus aureus and coagulase negative staphylococci. Intermediate-level resistance (MIC >8μg ml-1 >512μg ml-1) is thought to be due to spontaneous mutations in the native IRS. High-level resistance (>512μg ml-1) is conferred by a second IRS protein, encoded by mupA which has a much lower affinity for mupirocin than isoleucine.
The mupirocin resistance gene (mupA) is usually found on a 4.05kb EcoRI fragment of plasmids of otherwise varied EcoRI restriction pattern which are easily transferred between strains by filter mating. Prior to the onset of these studies, mupirocin resistance had not been found linked to another resistance determinant. Initial investigations intended to identify mechanisms of gene flux resident on mupA plasmids revealed a family of related mupA plasmids, the p3356 family which includes three plasmid types: p3356, p3356D and p3358.
p3356 contains a single copy mupA flanked by direct repeats of the staphylococcal insertion sequence IS257. p3356D is identical to p3356 except for the duplication of a "mupA-IS257" cassette in tandem repeat. p3358 is related to p3356D by the insertion of a pT181-like plasmid (tetracycline resistant) accompanied by the duplication of an IS257 in direct repeat to flank the inserted pT181; thus p3358 is the first documented example of linked resistance between mupirocin and another resistance determinant, namely tetracycline.
IS257 has been implicated as the recombinogenic site in the gene duplication event involved in the evolution of p3356D from p3356. IS257 co-integrative transposition has been demonstrated to allow the co-integration of pOX7 with p3356 to generate a p3358-type plasmid in which pT181 is replaced by pOX7. Therefore, it is concluded that IS257 transposition and recombination is a mechanism by which staphylococcal replicons can evolve to form multiply resistant replicons.

Advisor: Dyke, K
Studies of glucose metabolism in tumour cells and hybrids derived from them

Earlier studies had shown that an abnormality in the carbohydrate moiety of a cell membrane glycoprotein was closely linked to malignancy and that this glycoprotein might function in the transport of glucose into the cell. In this study the possibility that functional alterations in hexose transport might be linked to malignancy was investigated.
The kinetic parameters of uptake of the hexose 2-deoxy-D-glucose were measured for a variety of cell types and for hybrids between malignant and non-malignant cells. Hybrids in which malignancy was suppressed were compared to segregant tumours derived from them. Non-tumorigenic derivatives of tumour cells were also investigated. In every case, malignancy, i.e. the ability to grow progressively in vivo, was found to be linked to a decrease in the Michaelis constant of uptake. This association was found for both mouse and human cells and hybrids.
Independent measurement of the transport and phosphorylation steps involved in uptake revealed that this difference resided in the transport step which was rate-limiting for overall uptake.
Malignancy was also associated with a difference in response to glucose deprivation. The maximum velocity of hexose uptake of malignant cells was increased by glucose deprivation whereas that of non-malignant cells remained largely unchanged.
The maximum velocity of fibroblastic cells was increased by viral transformation.
The Michaelis constant of uptake was increased by tunicamycin demonstrating the importance of glycoprotein glycosylation for hexose transport.
Autoradiographic analysis of the distribution of hexose uptake capacity within cell populations revealed marked heterogeneity. There was a fast-transporting sub-population and enrichment for this was achieved in cell fractionation experiments with the monoclonal antibody M/27 which defines a transportassociated antigen.
Measurement of the uptake of D-glucose itself by rapid filtration centrifugation gave similar results to those obtained with 2-deoxy-D-glucose.

Advisor: Bramwell, M
Minor women novelists and their presentation of a feminine ideal, 1744-1800

From the 1740s to 1800 there was a great increase both in the output of novels, and the number of women novelists. At the same time, an idealized view of femininity was prevailing in society. The relationship between these two features of eighteenth-century life helps us to assess the contribution of some eighteenth-century women to the development of the novel.
In this period women's novels show some distinctive features, particularly in their portrayal of women. The idealized eighteenth-century view of women saw them as naturally virtuous, chaste, and full of the sensibility which was increasingly seen as an important positive quality. Therefore an idealized woman is the central figure in many sentimental novels. This idealized figure, used especially by women novelists, is of ambiguous significance. She raises women's status by demonstrating female superiority, but does so by modesty and submissiveness, qualities which eighteenth-century feminists perceived as inimical to women's emancipation. Women's novels often contain contradictions between explicit support of female emancipation, and idealized portraits of submissive heroines.
Chapter 1 discusses the reasons for the rise of the woman novelist. Chapter 2 discusses her role and the reviewers' part in defining that role. Chapter 3 discusses women novelists in relation to feminism. The following chapters focus on particular writers. Sarah Fielding is a didactic writer with a certain feminist consciousness. The novels of Frances Brooke and Elizabeth Griffith epitomize the idealization of the heroine. The comic attack on the heroine is described with reference to Charlotte Lennox's work. The"relationship between sentimental- ism, didacticism and feminism is studied with reference to Clara Reeve and Harriet Lee. Chapter 8 introduces the 1790s, when politics dominates fiction and sentimentalism is attacked, and chapters on Jane West, Mary Wollstonecraft, and Charlotte Smith suggest the variety of women novelists' responses to these developments.
The impact of capital and labour availability on smallholder tree growing in Kenya

Smallholder tree cultivation and management is a common form of land-use in high potential areas of Kenya. Some practices, such as the planting of trees on field boundaries are strongly rooted in customary notions of land and tree tenure. Others, such as the planting of black wattle (Acacia mearnsii) woodlots, are more recent innovations, introduced to produce commodities for domestic and export markets. This thesis explores the historic, cultural, and economic dimensions of tree growing in Kenya, using archival and ethnographic data, land-use surveys, and results from a survey of 123 households in the upper coffee/lower tea zone of Murang'a District.
The household survey was designed to explore the hypothesis that tree growing complements formal employment as a strategy for overcoming poorly operating factor markets and helps to ease land-use constraints imposed by labour migration. Tree planting is favored because of its low capital and recurrent costs and when farmers are unable to plant other more resource-intensive crops. The survey focused on households which currently maintain a black wattle woodlot and on households which operate parcels which were used for growing black wattle in 1967, but which have since been cleared and are being used for growing something else.
The survey showed that woodlot growing households operate larger parcels, are older, support fewer residents, and have more non-resident relatives than other households in the survey. Woodlot growing parcels are also at a lower altitude and are more steeply sloping than other parcels. Patterns of resource allocation suggest that woodlot growing households are more risk averse.
Logistic regression (logit) modeling explored causal relationships, suggesting woodlots are indeed more likely to be established as households age and as labour becomes scarce, and that woodlot clearance takes place when labour is more available to cultivate the holding.

Advisor: Arnold, J
Collier, P
Arnold, M
Reaction engineering for protein modification: tools for chemistry and biology

Chemical modification of proteins is critical for many areas of biochemistry and medicine. Several methods for site-selective protein modification are reported in this Thesis that are useful in accessing both natural and artificial protein architectures. Multiple, complementary methods for the conversion of cysteine to dehydroalanine are described. Dehydroalanine is used as a general precursor to several post-translational modifications and glycosylation, polyprenylation, phosphorylation, and lysine methylation and acetylation are all accessible. These modifications and their mimics were explored on multiple proteins, including histone proteins. Unnatural modifications were also explored. The first examples of olefin metathesis and Suzuki-Miyaura cross-coupling on protein substrates are reported. Allyl sulfides were discovered to be remarkably reactive substrates in olefin metathesis, allowing use of this reaction in water and on proteins. For Suzuki-Miyaura cross-coupling, a new catalyst is described that is fully compatible with proteins. Both olefin metathesis and cross-coupling allow the formation of carbon-carbon bonds on proteins. The prospects of these transformations in chemical biology are discussed. Finally, a novel strategy is reported for the installation of natural, unnatural, and post-translationally modified amino acid residues on proteins. This technology relies on addition of carbon radicals to dehydroalanine. This method of "chemical mutagenesis" is anticipated to complement standard genetic manipulation of protein structure.

Keywords: Dehydroalanine
Cross-Coupling
Cysteine
Palladium
Olefin Metathesis
Protein Chemistry
Catalysis
Organic Chemistry
Enzyme
Protein Modification
Aqueous Chemistry
Ruthenium
Histone
Reaction Engineering
Biochemistry
Advisor: Davis, B
'And I am re-begot': the textual afterlives of John Donne

This thesis is a cultural history of the textual afterlives and poetic appropriations of John Donne's verse. I use print and manuscript miscellanies, hitherto unstudied commonplace books, letters, diaries and seventeenth and eighteenth century criticism to ask, who was reading Donne and in what physical forms? By looking at allusive strategies and reading practices of the time, I demonstrate how many different Donnes can be identified when we strip away modern notions of what 'Donne' is and seek multiple afterlives. I nuance the idea of Donne as a determinedly coterie poet, suggesting his print presence might have looked to his early audience like a strategic writer who had not, despite Izaak Walton's narrative, closed off the possibility of public authorship. I find there was a period of radical re-appropriation and re-reading of Donne in the seventeenth and eighteenth century: Donne was as a guiding influence to canonical poets. Rochester is perhaps the poet whose voice most vividly recalls Donne's swaggering persona and intricately-constructed rendering of apparent spontaneity. Katherine Philips's verse makes sophisticated use of Donne's voice in her intimate quasi-erotic verse; I contrast this with the voice of her poems written for state occasions to show how Donne becomes a resource for self-revelation. Dryden offers a sustained critical vision of Donne: although, as the primary mercenary proponent of mass popular literature, he may seem initially wholly unDonnean, I show how his verse both explicitly and obliquely negotiates with Donne's wit and form. I end by looking at the problematic offered by the negotiates with Donne's wit and form. I end by looking at the problematic offered by the dual critique and celebration in Pope's versification of Donne's Satyres, and at the Dunciad, to see where the limits of allusion come up against Pope's cacophonous multiplicity of voices. These four poets take different threads from Donne's canon to different ends and, in so doing, create different Donnes.

Keywords: Donne
Dryden
Rochester
Advisor: van Es, B
Magneto-optics of InAs/GaSb heterostructures

The optical properties of InAs/GaSb heterostructures under applied magnetic fields are studied in experimental and theoretical detail. The InAs/GaSb system is a type-II "crossed-gap" system, where the valence band edge of GaSb lies higher in energy than the conduction band edge of InAs. This leads to a region of energy above the InAs conduction band where conduction and hole states mix. Thin-layer superlattices remain semiconducting due to confinement effects, but thick-layer superlattices experience charge transfer which leads to intrinsic carrier densities approaching 1012 cm-2 per layer.
Existing multi-band modeling techniques based on the k·p formalism are discussed, and a method of solving superlattice band structure (the "momentum-matrix" technique) is presented. The quantizing effects of the superlattice layers and applied magnetic fields are investigated, and the selection rules for optical transitions are derived.
Standard cyclotron resonance (CR) is used to study effective masses in InAs/GaSb structures. The heavy hole mass is found to be strongly orientation-dependent, with a mass in the [111] orientation reduced 25% from the [001] mass. The electron mass is found to be roughly isotropic with respect to growth orientation, but shows variation with the InAs width due to quantum confinement effects. CR of InAs/GaSb heterojunctions display hitherto unexplained oscillations in linewidth, intensity, and effective mass. A model is proposed which explains the oscillations, based on the intrinsic nature of the InAs/GaSb system.
CR is performed on an InAs/GaSb heterojunction using a free-electron laser, where due to the high intensities (on the order of MW/cm2) the absorption process saturates. This saturation allows for a determination of non-radiative relaxation lifetimes, and through the energy dependence of these lifetimes the magnetophonon effect is observed, allowing a direct measurement of LO-phonon-assisted energy relaxation rates.
Coupling is introduced into the standard CR experiment, either by tilting the sample with respect to the magnetic field, or by applying a metal grating to the surface. These coupled CR experiments have striking qualitative results which allow for determination of subband separation energies and coupling matrix elements.
Photoconductivity experiments are performed on thin-layer (semiconducting) superlattices, showing optical response at far-infrared wavelengths (5-20 μm). The results are compared with k·p calculations. One sample is processed for vertical transport, in which conduction occurs perpendicular to the superlattice layers. Strong optical response from this sample indicates the viability of InAs/GaSb-based far-infrared detectors.
The momentum-matrix technique is used to predict optimum parameters for semiconducting superlattices with band gaps in the far-infrared. Semimetallic structures are studied via a multi-band self-consistent model, with results corroborating with and extending previous work. Intrinsic structures under applied magnetic field are modeled theoretically for the first time.

Advisor: Nicholas, R
Long-distance coarticulatory effects of English /l/ and /r

This thesis explores the coarticulatory effects of English /!/ and /r/, examining their articulatory basis, acoustic manifestation and perceptual relevance. It demonstrates that there are perceptually relevant coarticulatory differences associated with the distinction between /l/ and /r/. Two perceptual experiments, an articulatory experiment and a modelling study were conducted. Both perceptual experiments used a modified gating technique. The first experiment demonstrates that the coarticulatory effects of /l/ and /r/ on surrounding vowels and consonants can sometimes be used by listeners to identify an HI or /r/ which has been deleted and replaced by noise. The second perceptual experiment shows that the cues for an /r/ are more perceptually salient than those for an /l/. The articulatory experiment used simultaneous electromagnetic articulography, electropalatography and acoustic recordings to investigate the coarticulatory effects of /l/ and /r/. In /r/ contexts, relative to /l/ contexts, raising and retraction of the tongue, lip rounding and lowering of F₃ were found, up to two syllables preceding and following the /r/. The extent of this coarticulatory effect is far greater than commonly acknowledged in the coarticulation literature. Phonetic and phonological theories fail to predict or account for effects of this extent. The theory that coarticulation can be modelled as overlap of articulatory gestures was tested in a modelling study. A subset of the articulatory data was modelled numerically using dynamical descriptions of articulatory gestures from an approach developed at Haskins Laboratories. The modelling showed that longdistance coarticulatory effects could not be adequately accounted for by gestural overlap alone. Feature-spreading models, such as Keating's window model of coarticulation, are also unable to account for these effects adequately. The results of this thesis pose a challenge to current phonetic and phonological theory, as they show that coarticulatory effects have greater extent than commonly recognised.
New methods for the synthesis of aromatic compounds

Introduction
The introduction describes the importance of arylamine compounds to society and provides a brief overview of the methods available for their synthesis. The application of metathesis catalysis to the de novo synthesis of heteroaromatic compounds is also described.
Results and discussion
The first section describes efforts towards the de novo synthesis of arylamines using a cross metathesis/oxidation protocol to form a 1,5-unsaturated dicarbonyl followed by an amine mediated cyclisation. The scope with respect to the 1,5-unsaturated dicarbonyl and amine is covered as well as the utility of some of the products. The section concludes with a modification of the Bohlmann Rahtz pyridine synthesis to furnish arylamines.
The next section describes the applications of our methodology to the synthesis of naphthylamines, specifically using the palladium catalysed α-arylation reaction. A discussion of the α-arylation reaction is included as well as our efforts to explore the scope of the reaction.
The third section follows our efforts to apply this methodologyy to the synthesis of five benzo[c]phenanthridine alkaloids including the first reported synthesis of maclekarpine B and C.
The final section concludes with a discussion of our efforts towards the de novo synthesis of furans bearing a benzylic stereocentre.

Keywords: synthesis
methodology
Aryl amine
natural product
heterocycle
Advisor: Donohoe, T
The nation-state form and the emergence of ‘minorities’ in French mandate Syria, 1919-1939

Abstract (i): The first part of this thesis questions the concept of ‘minority’, and the way it has been used to analyze French imperial policy in Syria (‘divide and rule’). Chapter 1 traces the concept’s emergence, showing that it is not self-evidently valid but rather depends on a set of wider social and political circumstances related to the existence of modern nation-states: the minorities of modern Syria cannot be mapped directly back onto the Ottoman millets or religious communities. Chapter 2 examines the term’s application in Syria between the wars: French imperial policy emphasised divisions in Syrian society, but the term ‘minority’ was only systematically attached to these divisions from the 1930s. The concept’s spread in Syria reflects its growing importance in international public discourse worldwide, as the nation-state became the standard state form after World War One. The second part of the thesis uses case studies of particular themes to show how the emergence of minorities illuminates processes of state-formation that have shaped the modern world. Chapters 3 and 4, on the question of ‘separatism’ and the definition of modern Syria’s northern border, examine the spread of effective state authority across a ‘national’ territory. This process bound culturally-divergent populations more tightly into the fabric of a centrally-controlled state, thereby constituting them as ‘minorities’. Chapter 5 examines the debate about a Franco-Syrian treaty leading to Syrian independence, showing that this made the recently-established body of international law on ‘minorities’ in newly-independent states applicable to Syria: the term only became widespread in Syria at this time. Chapter 6 looks at French efforts to reform personal status law in the later 1930s, when the restructuring, on religious lines, of the institutional relationship between the Syrian state and its population created a new uniformity within communities at the national level (one condition for their developing the sense of being ‘minorities’). It also sparked opposition from groups now claiming to represent the ‘majority’. Other Syrians, though, understood their society in different terms.

Keywords: Syria
minorities
French Mandate
imperialism
Advisor: Rogan, E