VictorJuiz/thesis huggingface dataset:
Wordsworth's scriptural topographies

In 1963, M.H. Abrams suggested that the ultimate source of Wordsworth's poetry is the Bible, and, in particular, the New Testament. This thesis, however, demonstrates the importance of the Old Testament and offers the first extended analysis of Wordsworth's use of Old Testament rhetoric. It examines both his affectionate perceptions of the natural world, and the Biblical recollections that saturate his writing. The purpose is to align two critical discourses - on Scripture and topography - and in doing so, situate Wordsworth's sense of himself as a poet-prophet in both Britain and America.
The four chapters are structured topographically (Dwelling, Vales, Mountains, Rivers), and organised around a phenomenological experience of lived space, as expressed in key poems. Close analysis of Wordsworth's poetic language from Descriptive Sketches to Yarrow Revisited reveals the influence of the Bible (and the recent analysis of sacred Hebrew poetry undertaken by Lowth), while the theories of Heidegger and Bachelard provide a conceptual approach to Wordsworth's investment in nature. The epilogue opens questions of Wordsworth's reception in America by exploring the awareness of cultural and physical geography and sense of Wordsworth's prophetic ministry amongst his heirs. The thesis concludes that Wordsworth's extensive recourse to scriptural language and the physical landscape strengthened his claim to be a Prophet of Nature. His poetry self-consciously adopted the universal 'language of men' - that of the King James Bible.

Keywords: Romanticism
Nineteenth Century
America
Prophecy
Lake District
Heidegger
Rivers
Topography
Bachelard
Cultural Geography
Dwelling
Mountains
Scripture
Vales
William Wordsworth
King James Bible
Advisor: Stafford, F
‘It's easier if we stop them moving’ a critical analysis of anti-child trafficking discourse, policy and practice – the case of southern Benin

This thesis offers a critical assessment of anti- child trafficking discourse, policy and practice, using a case study of the situation in Southern Benin. It seeks to achieve two main goals. First, to transcend the reductiveness of the dominant paradigm around child trafficking, including dominant representations of it and prevailing policy approaches to dealing with it. Second, to complicate the simplistic nature of much of the academic literature that explains the existence and persistence of this dominant paradigm. Based on 14 months of multi-sited fieldwork, the thesis demonstrates, first, that the institutional narrative of ‘child trafficking’ misrepresents what would be better understood as adolescent labour migration in Benin, and second, that mainstream policy approaches to tackling this fail to account for the sociocultural or political-economic conditions that underpin it. The thesis suggests that this can be interpreted as a result of the power of three framing orders of discourse – ‘Apollonian Childhood’, Neoliberalism and that of the Westphalian State – which structure both what ‘trafficking’ can mean and what can be done about it. The thesis suggests that the material and power structures of the anti-trafficking discourse- and policy-making field are such that, even where individuals within it reject both the dominant paradigm and its (and the field’s) framing orders of discourse, little space exists for them to construct meaningful alternatives. The result is a degree of formal and representational stability, hiding practical hybridity. The conclusion is offered that, while anti-trafficking discourse is presumed to be accurate and while antitrafficking policy is justified in terms of its contribution to ‘beneficiaries’, theprinciple achievement of both is the depoliticised reproduction of the institutions, orders of discourse and political-economic context within which they are constructed.

Keywords: Benin
anti-trafficking policy
child trafficking
trafficking discourse
Advisor: Boyden, J
Anderson, B
The interface between competition and the internal market: market separation under Article 102TFEU

The thesis explores the interface between competition law and market integration, in the application of Article 102TFEU. It focuses on ‘market separation’ and addresses conduct that has the intent, or effect, of hindering cross-border trade, either in the form of geographic price discrimination or in the form of exclusionary abuses, in which out-of-State competitors are affected.
In doing so, the thesis delves into a comparative analysis of the Treaty requirements under Article 102TFEU when applied in market separation cases and the Treaty requirements under the free movement provisions. It begins with a comparison of the objectives of the two sets of provisions and assesses how their historical link is echoed, presently, in the requirement of ‘effect on trade’ under Article 102TFEU (Chapter I). Following this, the thesis explores the asymmetry as between the addressees of the two sets of provisions (Chapter II). It is argued that ‘undertaking with a dominant position’, as a distinct condition of the application of Article 102TFEU, is the outer limit to any expansive view of direct horizontal applicability of the freedoms. Therefore, alleged market separation by dominant undertakings should be subject to Article 102TFEU alone.
Subsequently, the material scope of the prohibitions contained in the two sets of provisions is addressed. Here, it is argued that, in the vast majority of market separation cases, there is nothing special about the interface between competition law and the Internal Market. Rather, the inherent limits of economic integration, as reflected in the notion of trade barriers, should also be taken into account under the enforcement of Article 102TFEU against dominant undertakings (Chapter III). Tensions between competition law and the Internal Market may, nevertheless, arise when non-economic values, as reflected in the notion of justified trade barriers, come into play. In these cases, the interface between competition law and the Internal Market is better conceptualised as a question of unclear attribution of the market distorting effect to the undertaking and/or the State (Chapter IV). A revised defence of shared responsibility for the market separation is proposed, which would render the legality of State intervention under the free movement provisions a necessary condition for the application of Article 102TFEU against the dominant undertaking (Chapters V and VI).

Keywords: abuse of the dominant position
free movement of goods
internal market
market integration
market separation
Article 102TFEU
Advisor: Ezrachi, A
Ziegler, K
The weak vs. the strong: African, Caribbean and Pacific countries negotiating free trade agreements with the European Union 

This thesis seeks to explain the outcomes of trade negotiations between the European Union (EU) and seventy-six of the world’s smallest developing countries in Africa, the Caribbean and Pacific (ACP). Puzzlingly, in spite of its vastly greater economic size, the EU was, for the main, unable to realise its objective of concluding six broad and deep free trade agreements with these countries.
Deploying first historical institutional analysis then statistical modelling and finally by scrutinising a wealth of primary documents and transcripts of interviews with negotiators, the thesis reveals three factors that influenced outcomes. First, coercive pressure applied by the EU on countries dependent on EU for trade preferences and aid. Second, tactics within the negotiating process, with some ACP countries and regions manoeuvring more effectively than others. Third, differences in the underlying preferences of ACP governments, with most opposing major aspects of the EU’s proposals, but a minority embracing the EPA approach. Probing the underlying reasons, the thesis finds that, contrary to the prevailing literature, lobbying by domestic economic interest groups only provides part of the answer – the analytical and ideational processes within ACP government institutions also exerted an influence.
The analysis shows that structural factors, particularly the depth of economic and political dependence on the larger state, establish the range of likely outcomes from a given negotiation. However the preferences of small states and the way in which they interact strategically with the larger state can definitively shape the final outcome. In particular, small states can exercise a degree of resistance and blocking power that is often underestimated. It also sheds light on the formation of trade preferences in small developing countries and shows that in addition to lobbying by external groups, information and ideas within government bureaucracies appear to play an important role.

Keywords: Pacific
Africa
negotiation
economic partnership agreement
European Union
developing countries
Caribbean
free trade agreement
international trade
Advisor: Woods, N
Interactions between avian colonial social structure and disease dynamics

All wildlife populations harbour parasites. However, seabirds are likely to play a particularly important role in the maintenance and dispersal of infectious agents as a result of their colonial breeding habits. Seabird colonies are also known to be highly spatially structured, but little is known about the effects of this spatial structuring on seabird parasite dynamics. In this thesis, I use a tick-borne virus, Great Island virus (GIV), found in a large common guillemot (Uria aalge) colony bordering the North Sea as a model system to explore this relationship. I use a multidisciplinary approach, framed by a simple epidemiological model of the guillemot-tick-virus system.
In Chapter 2, I describe a novel epidemiological model and parameterise it using the existing literature. The model suggests the importance of spatial structure within the guillemot colony, but also identifies a key missing parameter, the rate of virus transmission between pre-breeding and breeding areas. In Chapter 3, I go on to test the potential role of independent tick movement in driving transmission between these two areas, by quantifying the mobility of host-seeking seabird ticks, Ixodes uriae. I show the potential for ticks to walk ranges described anecdotally in the literature, in just a few minutes, but stress the importance of further experiments in the field./p>
Chapter 4, I test the potential role of guillemot-mediated tick movement between pre-breeding and breeding areas. I show that pre-breeding guillemots spend a limited proportion of time ashore during daylight hours, which increases significantly as the season progresses and varies between individuals. A similar pattern is observed when considering how often they enter breeding areas when ashore; generally infrequently but varying spatiotemporally and between individuals. In Chapter 5, I apply finite mixture modelling techniques to improve existing estimates of age- and strain-specific GIV seroprevalence and force of infection in the guillemot colony. I also provide the first estimates of these parameters for eight strains, and highlight the importance of understanding strain-specific differences in GIV dynamics in future studies./p>
Finally, I bring all four data chapters together in Chapter 6, by inputting my new parameter estimates (Chapters 3-5) into my existing model (Chapter 2). Taken together, my results suggest that GIV transmission within the guillemot colony may increase in the future as a result of declining breeding abundance and success, with more frequent or extreme disruption leading to a higher risk of infection within the colony. More generally, my results suggest that seabird colonies can be highly sensitive to changes in their spatial structure, and that endemic parasites have the potential to substantially impact, and hence to be an added threat to, their seabird hosts.

Keywords: seabird
transmission
spatial structure
colony
tick-borne virus
herd immunity
Advisor: Sheldon, B
McLean, A
Godfray, C
Nunn, M
Wanless, S
Patterns of symptoms in major depressive disorder and genetics of the disorder using low-pass sequencing data

My thesis aims at identifying both genetic and environmental causes of major depressive disorder (MDD), using a large case-control study: 6,000 Chinese women with recurrent MDD and 6,000 controls. One of the major challenges for conducting genetic research on MDD is disease heterogeneity. The first question addressed is how different MDD is from highly comorbid anxiety disorders. I examine how anxiety disorders predict clinical features of depression and the degree of heterogeneity in their predictive pattern. The second question addressed is whether clinically defined MDD is a single disorder, or whether it consists of multiple subtypes. Results are then compared with and interpreted in the context of Western studies. Furthermore, latent class analysis and factor analysis results are also used in association analysis to explore more genetically homogeneous subtypes. Genetic data were derived using a novel strategy, low pass whole genome sequence analysis. Using genotypes imputed from the sequence data, I show that a cluster of single nucleotide polymorphisms (SNPs) is significantly associated with a binary disease phenotype including only cases with ≥ 4 episodes of MDD, suggesting that recurrence might be an indication of genetic predisposition. The third issue examined is the contribution of rare variants to disease susceptibility. Again using sparse sequence data, I identified exonic sequence variants and performed gene-based analysis by comparing the number of variants between cases and controls in every gene. Furthermore I performed gene enrichment test by combining P values of SNP association tests at different minor allele frequency ranges. Overall, I did not find convincing evidence that rare variants aggregately contribute to disease susceptibility. However, the gene-based analysis resulted in an unexpected finding: cases have an excess of variants in all thirteen-protein coding mitochondrial genes, which was due to copy number differences in the mitochondrial genome. Both human phenotypic data as well as mice experimental data show that the increase in the mitochondrial copy number in cases is due to chronic stress.

Keywords: major depressive disorder
genome-wide association study
mitochondrial DNA
comorbid anxiety disorders
rare variant analysis
Advisor: Flint, J
Multi-species detection using infrared multi-mode absorption spectroscopy

This thesis reports work extending the scope of a recently developed gas sensing technique, multi-mode absorption spectroscopy (MUMAS). The ability of MUMAS to simultaneously detect multiple species from a mixture is demonstrated for the first time. The technique is subsequently extended to mid-infrared wavelengths, realising large gains in sensitivity.
A solid-state, multi-mode laser has been developed to provide a high-performance comb source for use with MUMAS. This in-house constructed, diode-pumped, Er/Yb:glass laser operates on 10 longitudinal modes, separated by 18 GHz and centred close to 1565 nm. The extensive development and prototyping work leading to this final laser design is described.
Multi-species detection with MUMAS is reported for the first time, thus demonstrating the ability of this technique to perform multi-gas sensing using a single laser and simple detection scheme. The previously described Er/Yb multi-mode laser was used to record MUMAS signals from a sample containing CO, C2H2, and N2O. The components of the mixture were detected simultaneously by identifying multiple transitions in each of the species. Temperature- and pressure-dependent modelled spectral fits to the data were used to determine the partial pressures of each species in the mixture with an uncertainty better than +/-2%.
Multi-mode radiation has been successfully generated at 3.3 μm using quasi phase matched difference frequency generation (QPM-DFG). A mid-infrared laser comb was produced by optically mixing the near-infrared, multi-mode comb produced by the previously developed Er/Yb:glass laser with the single-mode output of a Nd:YAG laser operating at 1064 nm. This multi-frequency laser source was characterised to verify performance, and subsequently used to perform proof-of-principle MUMAS measurements on the strong transitions found in this spectral region. Spectra were recorded of NH3 and CH4 both individually and as components of a mixture. A minimum detection level for this system was determined to be 4.3 μbar m-1 for CH4, a sensitivity increase of 300 over similar measurements performed in the near-IR.

Keywords: multi-mode absorption spectroscopy
difference frequency generation
gas detection
Laser spectroscopy
absorption spectroscopy
MUMAS
gas analysis
DFG
multi-mode laser
Advisor: Ewart, P
Cavitation-enhanced tumour-targeting virotherapy by ultrasound

Systemic administration of adenovirus type 5 (Ad5) vectors for the treatment of cancer is limited by poor circulation kinetics and inefficient uptake from the bloodstream into tumours. This study reports a novel method for linkage of highly-PEGylated gold nanoparticles (AuPEG) to Ad5 by a single reduction cleavable bond. The resulting ‘dandelion’ structure provides very effective steric shielding with only minimal and reversible modification of the Ad5 capsid. This ablates in vitro cell infection, improves protection against the binding of antibodies, and enhances in vivo circulation kinetics.
Focused ultrasound is a promising technology for the non-invasive, targeted treatment of cancer. In the context of drug delivery, cavitational energy generated upon exposure of ultrasound contrast agents to focused ultrasound can be used as a powerful stimulus to move therapeutics over distances of hundreds of microns away from blood vessels. In addition to providing a platform for effective stealthing, conjugation of AuPEG to Ad5 also increases the effective density of Ad5. This increase in density imparts a second major advantage on the strategy, observed for the first time in the present study: denser particles are transported significantly farther by cavitation-induced microstreaming than identically-sized particles of lower density. Specifically, in in vitro tests using a tumour-mimicking flow-channel phantom model and in in vivo experiments using tumour bearing mice, Ad5–AuPEG was delivered farther from vessels in response to ultrasound induced cavitation than either naked Ad5 or polymer-coated Ad5.
The enhancements in stealthing and improvements in response to ultrasound provided by this strategy enabled up to 12% (S.D. 0.97) of the injected dose to be deposited in the tumour, compared to just 0.12% (S.D. 0.05) for Ad5 without ultrasound (p < 0.001). Consequently, in a survival study, mice treated with Ad5–AuPEG with focussed ultrasound had the slowest tumour growth and longest survival rate when compared to mice treated with Ad5 alone, Ad5–AuPEG alone, or Ad5 with focussed ultrasound. These results provide compelling evidence that the combination of focussed ultrasound with density-augmented stealthed Ad5 results in improved delivery to tumours and therapeutic efficacy.
This combination of ultrasound with particle modification for optimal cavitation-mediated delivery has the potential to be applied to a broad range of anti-cancer nano-medicines and therapeutics to augment their bio-availability for improved cancer treatment.

Keywords: density
virus
adenovirus
Ultrasound
tumour
cancer
nanoparticle
gold
Advisor: Coussios, C
Seymour, L
Applications of whole genome sequencing to understanding the mechanisms, evolution and transmission of antibiotic resistance in Escherichia coli and Klebsiella pneumonia

Whole genome sequencing (WGS) has transformed molecular infectious diseases epidemiology in the last five years, and represents a high resolution means by which to catalogue the genetic content and variation in bacterial pathogens.
This thesis utilises WGS to enhance our understanding of antimicrobial resistance in two clinically important members of the Enterobacteriaceae family of bacteria, namely Escherichia coli and Klebsiella pneumoniae. These organisms cause a range of clinical infections globally, and are increasing in incidence. The rapid emergence of multi-drug resistance in association with infections caused by them represents a major threat to the effective management of a range of clinical conditions.
The reliability of sequencing and bioinformatic methods in the analysis of E. coli and K. pneumoniae sequence data is assessed in chapter 4, and provides a context for the subsequent study chapters, investigating resistance genotype prediction, outbreak epidemiology in two different contexts, and population structure of an important global drug-resistant E. coli lineage, ST131 (5-8). In these, the advantages (and limitations) of short-read, high-throughput, WGS in defining resistance gene content, associated mobile genetic elements and host bacterial strains, and the relationships between them, are discussed. The overarching conclusion is that the dynamic between all the components of the genetic hierarchy involved in the transmission of important antimicrobial resistance elements is extremely complicated, and encompasses almost every imaginable scenario. Complete/near-complete assessment of the genetic content of both chromosomal and episomal components will be a prerequisite to understanding the evolution and spread of antimicrobial resistance in these organisms.

Keywords: whole genome sequencing
Enterobacteriaceae
Antibiotic resistance
Molecular epidemiology
Advisor: Crook, D
Peto, T
Donnelly, P
Women and rhetoric

This thesis studies the ways in which female characters in Chaucer's poetry use language. Differences between feminine and masculine discourse in the Legend of Good Women and Troilus and Criseyde are examined, along with factors shaping the poetic articulation of the feminine in the Middle Ages.
Part I sets out the background material which provides the context for the close readings of Parts II and III. Since the framework within which Chaucer's female characters speak is poetic, the first chapter is concerned with contemporary views about how poetic meaning is produced: what is the status of the author? How does the author read - and rewrite - his or her sources? Which rhetorical conventions govern literary representation, and how is the literary text justified?
Part I also considers why rhetoric should be an issue as regards women in the Middle Ages, and what modes of signifying are available to women in social, spiritual and literary contexts. Perspectives on appropriate female behaviour and discourse are gained through an examination of the rhetorical traction, works of devotional and didactic instruction, and the conventions of fin'amor.
Parts II and III present a close reading of Chaucer's poetry. The readings are informed by the perspectives outlined in Part I, and by modern literary theories, and involve some assessment of the applicability of recent theory to Chaucer's poetry. The Legend of Good Women and Troilus and Criseyde are both seen as vitally concerned with poetic practice and theory, and with the poetic representation of female characters. The poet's representation of the heroines in the course of the Legend provides a critique of the conception of poetry articulated by the god of Love in the Prologue. The hermeneutical and representational difficulties that the poet of the Troilus experiences with his poem are intimately linked with his treatment of Criseyde. The thesis considers the intersection between poetics and the poetic representation of the feminine.