VictorJuiz/thesis huggingface dataset:
A meta-analysis of parent management training outcomes for children and adolescents with conduct problems

This thesis comprised a meta-analysis examining the efficacy of Parent Management Training (PMT) for children and adolescents with conduct problems (CP). A search of the published literature yielded 499 studies, of which 80 met criteria for inclusion. These 80 studies generated 461 standardized mean gain effect sizes representing pretest to posttest change on measures of child CP for 119 intervention groups comprising 3325 individual youth and 42 control groups or 1645 individual youth. Hundreds of additional effect sizes were calculated for outcome variables examining generalization and collateral effects of PMT. Follow-up data at six months, one year, and beyond one year were also available. The analysis confirmed that PMT is a successful intervention in reducing childhood CP with maintenance of gains up to at least one year. Significant differences were found depending on which source was reporting on child CP. Parent-reports were associated with the greatest improvements, independent observers saw more modest gains, and teachers reported very little change. Child characteristics, family characteristics, methodological quality, and treatment quality were found to significantly moderate outcome. Other moderators (e.g., ADHD co-morbidity, father involvement, SES) demonstrated mixed effects and require further study and replication. In terms of cost-effectiveness, self-administered training, which was the least costly form of intervention examined, was not as effective as group or individual treatment. Moreover, standard PMT was more effective than programs that also sought to provide teacher training and/or child behaviour therapy. Results suggested that some generalization strategies as well as therapeutic enhancements directed toward parents are likely to improve treatment effects. The results are discussed in relation to previous meta-analyses and implications for research and practice.

Keywords: Conduct disorders in children, Treatment
Conduct disorders in adolescence, Treatment
Parenting, Study and teaching
Child rearing, Study and teaching
Child psychotherapy, Parent participation
A Gramscian historical-materialist analysis of the informal learning and development of black working-class organic intellectuals in Toronto, 1969--1975 (Ontario)

This research seeks to explore the political-economic, cultural, organizational and educational development of the Toronto Black Communist activists who engaged in local anti-racist and labor activism during the period of 1969 to 1975---a watershed period of radicalism under-represented in current scholarly literatures. I examine the dimensions of Black Communist and broader working-class politics in Toronto in terms of the following: historical and political economic contexts; migration patterns; gendered relations; influential political organizations and community groups; and finally, written texts, and theoretical literatures. Also, three spheres of informal learning that played an important role in the development of Black Working-Class Organic Intellectuals are analyzed: (1) Inter-Generational Learning relations; (2) Organization of African-Canadian working-class social movements; (3) Experience of race, gender, and class contradictions in the Canadian capitalist economy, state and civil society.

Keywords: Blacks, Social conditions
Blacks, Ontario
Labor movement, Ontario
Group identity, Ontario
Identity (Psychology), Ontario
Racism, Ontario
Blacks, Race identity
Communists, Ontario
Blacks, Politics and government
Blacks, Ontario
Blacks, Intellectual life
Blacks, Ontario
Blacks, Civil rights
Blacks, Ontario
Working class, Ontario
Parent's knowledge of English first and second language children's literacy and numeracy development

The study investigated English first language (EFL) and English second language (ESL) parents' knowledge of their children's early reading and math development. Univariate analyses of variance were employed to determine if parents' and teachers' judgments were accurate indications of children's performance scores. Parents' frequency of communication with the teacher was also measured, in order to determine if differences in parents' knowledge could be attributed to their frequency of communication with the teacher. Results indicated that parents had knowledge of their children's math abilities, and teachers had knowledge of reading. Although English first and second language parents differed in their frequency of communication with the teacher, there were no language group differences in parents' knowledge of their children's abilities. It is concluded that despite English second language parents' infrequent discussions with their children's teachers, their knowledge is comparable to that of English first language parents.
Pulmonary edema's effect on epithelial ion and fluid transport

The in-vivo clearance of alveolar pulmonary edema occurs by active transepithelial ion transport, 50% of which is amiloride- insensitive. In primary cultures of fetal distal lung epithelium (FDLE), the absolute amount of amiloride-insensitive activity is more than doubled by pretreatment with edema fluid (EF). Here I identify that an α- and β-globulin fraction contains the active component of EF. A mixture of α- and β-globulins stimulated the amiloride-insensitive pathway in a dose-dependant manner, as did commercially available rat albumin with known fatty acid and globulin contaminants. In both cases, globulin-free albumin had no effect. Identification and isolation of the active factor(s) within the globulin mixture may provide a novel therapy for pulmonary edema.
Adaptation of Saccharomyces cerevisiae to extreme environments: a comparison of haploidy versus diploidy

Diploid populations may have an advantage over haploid populations for adaptive evolution in having twice the number of genes and hence twice the total target size for beneficial mutations. Using experimental evolution studies to test this theory, isogenic haploid and diploid isolates of Saccharomyces cerevisiae were serially transferred for 300 and 500 generations in high pH and high salinity environments, respectively. After 300 generations in a high salinity environment, haploid and diploid populations had a higher fitness in the experimental environment relative to their progenitor populations. Upon genetic characterization of these populations, the haploid populations contained multiple, additive, beneficial mutations. The heterozygous diploid population had at least three mutations; two were dominant beneficial mutations and one was a recessive deleterious mutation. After 300 generations in a high pH environment, diploid populations showed a small increase in fitness, while haploid populations showed no increase in fitness in the experimental environment.
Genetic delineation of phosphotyrosine-dependent signal transduction by the ShcA protein in the mouse

The ShcA protein is broadly implicated in mammalian development and pathogenesis based on its ability to mediate activation of the Ras-Erk and other intracellular signaling pathways downstream of cell surface receptors that rely on intrinsic or associated tyrosine kinase (PTK) activity to transduce signals from the plasma membrane. This role of ShcA appears to primarily depend on its ability to coordinately bind with its amino-terminal PTB and carboxyl-terminal SH2 domains phosphotyrosine (pY)-binding domains to tyrosine-phosphorylated proteins concentrated within the activated receptor complex, and with the two pY-X-N (X = Y or V) motifs in its central CH1 region to the adaptor protein, Grb2. Analysis of mutant mice lacking ShcA has revealed that it is required for embryonic cardiovascular development in mammals. The cellular location(s) and mechanism(s) of ShcA signaling in this process, as well as its later pre- and post-natal roles, are unclear. To reveal where ShcA acts in development, I have produced mice with targeted ShcA alleles whose expression of ShcA can be irreversibly turned on or off via Cre-mediated DNA recombination. To investigate its mechanism(s) of signaling in development, I have generated mice with targeted ShcA alleles expressing either wild type ShcA-1xFlag proteins or mutant ShcA-1xFlag isoforms in which the pY-binding function of the PTB or SH2 domain is disabled, or the pY residues in the CH1 region are converted to phenylalanine residues in different combinations. Using these strains, I have collected data showing that ShcA in cardiomyocytes regulates mid-gestational heart development by mechanism in which the PTB domain but not the pYXN motifs are essential. In collaboration with others, I have collected additional evidence showing that ShcA employs its PTB domain, SH2 domain, and pY-X-N motifs in cis to regulate the formation of muscle spindles, sensory organs in skeletal muscles that, as part of the stretch reflex circuit, are essential for normal motor behavior in mammals. Altogether, these findings reveal previously unknown, cell type-specific roles for canonical and non-canonical ShcA signaling in mammalian development.
Pulp and paper mill effluents: characterization and effects on mosquitofish using continuous flow bioassay system

A continuous flow bioassay system was designed and constructed at a northwestern Ontario integrated pulp and paper mill. This system was employed to determine whether anal fin modification of mosquitofish (Gambusia afinis afinis ) would result from exposure to treated mill effluents. No effects on males or females were observed after exposure to 15% or 100% effluents for five months. Females exposed to control hormones did exhibit some effects. The loading and variability of chemical oxygen demand (COD), biochemical oxygen demand (BOD5), colour, total suspended solids (TSS), resin and fatty acids (RFAs), and sterols was determined for more than sixty untreated process effluents and treated effluents over a five month period. Major contributors to effluent loading were the effluent from power boiler wet sluicing and the effluents related to the kraft bleaching. A toluene reflux extraction method demonstrated an improved recovery of sterols versus a methyl-tert -butyl ether extraction.
Tort accountability of governments and institutions in the Canadian Health Care System

This paper explores the disconnect between changes in the health care system and the Canadian institutional and governmental tort jurisprudence. The clinical and policy literature increasingly recognizes that systemic actors carve out an important role for themselves in quality of care, and are in the best position to address and prevent injuries. In addition, the role of systemic actors in organizing the health care system, particularly given recent integration reforms, allows them a greater ability to affect quality of care. Canadian tort jurisprudence fails to reflect these changes, continuing to focus on the liability of physicians. This approach is in contrast to that of US and English courts, which employ greater institutional liability and show a more sophisticated understanding of the modern health care system. I argue that Canadian courts should similarly reconsider the legal relationships between patients and systemic actors, and be more sensitive to systemic causes for injuries.
Sources of variability in susceptibility and resistance to fetal alcohol spectrum disorder

Alcohol consumption during pregnancy can have numerous adverse health consequences on the developing fetus leading to Fetal Alcohol Spectrum Disorder (FASD). One compelling observation is that not all women who drink alcohol throughout their pregnancy have a child with an alcohol-related disorder; only 4% of chronic alcoholics have infants with full-blown FAS with another 30–40% having children with FASD. What mechanisms are involved that protects about 60% of fetuses exposed to alcohol in utero? In this thesis several sources of pharmacokinetic and pharmacodynamic variability are investigated. Ethanol concentrations show little variability among subjects. In contrast, acetaldehyde concentrations can be elevated in some, while undetectable in other alcoholics. A metaanalytic summary was conducted to determine the frequency of high acetaldehyde levels among alcoholics and compared to rates of FASD. An ecological resemblance between these two rates, suggests that acetaldehyde may play a determinant role in the extent and variability of fetal damage. Although high acetaldehyde concentrations may be present in alcoholic women, the role of the placenta in controlling how much acetaldehyde reaches the fetus is not known. Twin studies suggest that significant variability may exist among placentae in their ability to protect the fetus from toxic compounds. Using equilibrium dialysis, it was found that the amount of acetaldehyde bound to different human placentae varied, which may lead to 2-fold differences among placental acetaldehyde concentrations. The phenotype of FAS shares similarities with other disorders including pyruvate dehydrogenase (PDH) deficiency. In looking for a common mechanistic basis for both conditions, it is shown that acetaldehyde inhibits PDH activity at clinically relevant levels and concluded that impairment of PDH may have severe consequences for the developing fetus. As well, the extent of inhibition, which is dependent on the amount of acetaldehyde present, may explain the variable FASD phenotype. Finally, both twin and animal studies suggest that genetic factors influence the fetus' sensitivity to prenatal alcohol exposure. Using cDNA microarrays and a mouse strain that is susceptible to FAS, underexpression of 23 genes in fetal mouse brain exposed to alcohol in utero was found. No upregulated genes were identified. Identifying the function of these genes is critical in understanding the pathogenesis of FAS.
Multiculturalism within a bilingual framework: language and the racial ordering of difference and belonging in Canada

This thesis examines the emergence of 'multiculturalism within a bilingual framework' as the national formulation for the racial ordering of difference and belonging through language. As the 1960's began, a confluence of events resulted in challenges to the existing Anglo-Celtic dominant national narrative of belonging, and the Royal Commission on Bilingualism and Biculturalism (1963-1970) became the 'apparatus' through which the federal government addressed these contestations. This thesis argues that at this particular historical juncture, the need to rearticulate the formulation for nation building and national belonging meant a decisive shift onto the terrain of language and culture to organize and maintain a white settler hegemony while also disavowing racial and ethnic exclusions. Archival records and Commission reports reveal the conflicts and contestations which underlay the emergence of this ostensibly seamless linguistic and cultural policy of 'multiculturalism within a bilingual framework' as written through the Official Languages Act (1969) and the Multiculturalism Policy (1971). The emergence of these two defining legislative texts from the Royal Commission on Bilingualism and Biculturalism required the elision and erasure of substantive contestation from both Aboriginal communities and 'Other ethnic groups' (which is how non-French and non-English immigrant groups were defined throughout the inquiry) to the dominance of the terms of reference which centred the 'two founding races', the French and English, over the both the Other ethnic and Aboriginal groups. In the archival records of the inquiry hearings, it is possible to trace a genealogy of the eventual erasure of Aboriginal groups' claims and the muting of other ethnic groups demands culminating in the publication of the final reports. The shift from overt racial distinctions between founding and other ethnic groups onto the terrain of language and culture meant that racial exclusions could be disavowed as they were smuggled back in through the contradictory operation of language and culture. Furthermore, by fixing a narrow definition of 'multicultural' and 'integration' in federal legislation, claims for substantive and collective forms of recognition from the State for other ethnic groups could be limited. Alongside the concurrent changes to immigration legislation which were also taking place in the 1960's, language and culture are mobilized through the national formulation of multiculturalism within a bilingual framework in order to incorporate subjects into the contemporary racialized hierarchy of belonging and citizenship rights.
Decolonizing pedagogical approaches to aboriginal literatures in Canada

This thesis focuses on socially responsible strategies for teaching Aboriginal literatures in Canadian schools, particularly within Secondary level English courses. It articulates the need for a theorized methodology for reading as the basis of this pedagogical project, and argues that, within the context of colonial Canada, this methodology must be a decolonizing one. It outlines the fundamental components of a decolonizing methodology for reading, based on the following imperatives: rooting understanding in Aboriginality; valuing Aboriginal perspectives; challenging Eurocentrism and colonialism; maintaining a sense of reader responsibility; and challenging multiple forms of oppression. This project demonstrates a decolonizing methodology by examining Aboriginal texts by Beatrice Culleton Mosionier, Tomson Highway, Lee Maracle, and Chrystos. These examinations address such issues as colonial schooling in Canada, Aboriginal languages and their importance to Aboriginal cultures, and the possibilities offered by anti-colonialism feminism. Throughout, it raises considerations for educators pursuing an anti-colonial pedagogy through Aboriginal texts.

Keywords: Canadian literature, Indian authors
Decolonization, Canada
Anti-racism, Canada
Discrimination in education, Canada
The affect [sic] of psychotherapy and pharmacological treatment on sex offender relapse rates

The purpose of this study was to determine if sex offender treatment programs that utilize both medication and psychotherapeutic techniques as part of their treatment regimen had a different effect on treatment outcome (as measured by recidivism rate) than programs that were solely psychotherapeutic in technique. The study made use of meta-analytic techniques to quantitatively review the treatment outcome literature that exists for this particular population. Results indicate that treatment programs that use the combination of medication and psychotherapy were able to reduce the recidivism rate of sexual offenders by a larger amount than programs that used only psychotherapy. Some of the methodological problems that exist within the current literature are reviewed and suggestions for ways to improve future research are discussed.

Keywords: Recidivism, Prevention
Sex offenders
Psychotherapy
Sex crimes, Prevention
Chemotherapy
Trafficking and cell surface stability of the epithelial Na+ channel expressed in epithelial MDCK cells

The apically located epithelial Na+ channel (αβγENaC) plays a key role in the regulation of salt and fluid transport in the kidney and other epithelia. We generated epithelial Madin-Darby canine kidney (MDCK) cells stably expressing αβγENaC, where each subunit is differentially epitope tagged. ENaC expression was verified by immunoblotting and patch clamp analysis showed the tagged channel is functional. Moreover, we demonstrated apical membrane localization of ENaC in these cells. The glycosylation pattern of the intracellular pool of ENaC revealed sensitivity to endoglycosidase H. The cell surface pool of ENaC was also core glycosylated and lacked detectable endoglycosidase H-resistant channels. Extraction in Triton X-100 demonstrated that both intracellular and cell surface pools of ENaC are largely detergent-soluble. Moreover, flotation assays showed that both intracellular and cell surface pools of this channel are not associated with rafts. The surface pool of ENaC has a short half-life (t1/2 ∼ 1hr) in these cells.
A noble art for a modern age: The accurate, just, and polite rhetoric of David Hume

This thesis argues that David Hume's philosophy of mind commits him to assign an important role to rhetoric in political life and that the conception of rhetoric that emerges from Hume's writings is integral to his political philosophy. Hume's work was motivated by his interest in defeating the forces of faction and fanaticism. His philosophy of mind exposes the porous foundations of superstitious beliefs. It also reveals the power of rhetoric to elicit passions and to disseminate beliefs, both sound and superstitious. Hume was acutely aware of the dangers posed by rhetorically gifted fanatics. However, unlike many of his contemporaries, he saw these as dangers of fanaticism not rhetoric. Hume distinguished between the low cant of the fanatics and a higher form of rhetoric that I term accurate, just, and polite. For the most part, Hume thought the politicians of his day to be poor orators who were incapable of politeness. However, he held out hope for a politics in which the power of oratory could be turned toward the promotion of common goods and a general improvement of morals by providing a means through which interests could be opposed without producing violent factions. Hume's conception of high rhetoric combines his philosophy of accurate and just reasoning with a rhetorical style that appeals to the human compulsion to make judgments and eighteenth century standards of politeness. For Hume, politeness consists in the arts of conversation. Hume's is a distinctive conception of rhetoric that revives and modernises the ancient eloquence that he greatly admired. An accurate, just, and polite orator will employ the tropes and rhetorical style that Hume draws from an idealised vision of Demosthenes to promulgate and defend accurate and just arguments in a polite manner. Understanding how Hume's conception of rhetoric is rooted in his philosophical, historical, and political writings is important for understanding the full scope of his political philosophy as well as the insights he offers to students of political discourse who grapple with the truly philosophical question of how to distinguish positive from negative forms of political speech.