Reconstruction methods for accelerated magnetic resonance imaging [electronic resource]

Magnetic resonance imaging (MRI) is a powerful medical imaging modality widely used in clinical practice. MRI provides excellent soft-tissue contrast, and does not involve ionizing radiation. In an ideal clinical setting for MRI, several requirements have to be met. First of all, diagnostic image quality has to be achieved. Second, fast image reconstruction is required, so that the radiologists can review the images before releasing the patients. Third, fast data acquisition is desired. Short scan time can not only improve patient comfort, but also reduce many imaging artifacts and improve image quality. While advanced methods, such as parallel imaging and compressed sensing, can accelerate MRI data acquisition to some extent, the achievable scan time is still very limited for several MR applications. Meanwhile, the reconstruction time for these advanced methods can take up to hours, and become clinically infeasible. This dissertation describes approaches to maintain a clinically feasible reconstruction time for advanced reconstructions, and approaches to further accelerate MRI applications, specifically MR parameter mapping and dynamic contrast-enhanced (DCE) MRI. The ultimate goal of this work is to make MRI more clinically practical. To maintain a clinically feasible reconstruction time for advanced reconstructions with large coil arrays, a geometric-decomposition coil compression method is proposed. The proposed method exploits the spatially varying data redundancy of large coil arrays, and can compress the raw data from original coils into very few virtual coils. The advanced reconstruction can be directly performed on the virtual coils instead of the original coils. The reconstruction time for large 3D datasets, acquired with 32-channel coils and reconstructed by a combined parallel imaging compressed sensing method, can be reduced to under a minute. The proposed method has been implemented in Lucile Packard Children's Hospital at Stanford. The clinical evaluation suggests that the proposed method can achieve very fast reconstruction without compromising overall image quality and delineation of anatomical structures. MR parameter mapping is a promising approach to characterize intrinsic tissue-dependent information. To accelerate lengthy MR parameter mapping, which can take up to half an hour or more, a locally low-rank method has been proposed. The proposed method has been combined with parallel imaging to achieve further acceleration. Based on preliminary result, the combined parallel imaging locally low-rank method can accelerate variable flip angle T1 mapping by factor of 6, without obvious imaging artifacts. DCE MRI is a standard component of abdominal MRI exams, most commonly used to detect and characterize mass lesions and assess renal function. 3D DCE MRI is often limited compromised spatiotemporal resolution and motion artifacts. In this work, a combined locally low-rank parallel imaging method with soft gating is proposed. The proposed method can significantly reduce motion artifacts for completely free-breathing acquisition and remove the need for deep anesthesia. The high spatiotemporal resolution achieved by the proposed method can also capture the rapid contrast hemodynamics. The proposed method has been deployed clinically in Lucile Packard Children's Hospital at Stanford. Preliminary clinical evaluation results suggest that the proposed method can achieve an image quality very close to a respiratory-triggered data acquisition, but with much higher spatiotemporal resolution.

Keywords: Electrical Engineering.
Advisor: Pauly John (John M.) primary advisor. Thesis advisor
Nishimura Dwight George advisor. Thesis advisor
Vasanawala Shreyas