VictorJuiz/thesis huggingface dataset:
Economic Analysis of World's Carbon Markets

Forestry activities play a crucial role in climate change mitigation. To make carbon credits generated from such activities a tradable commodity, it is important to analyze the price dynamics of carbon markets. This dissertation contains three essays that examine various issues confronting world’s carbon markets. The first essay investigates cointegration of carbon markets using Johansen maximum likelihood procedure. All carbon markets of the world are not integrated. North American carbon markets show integration and so do the CDM markets. For future, the possibilities of arbitrage across world’s markets are expected to be limited, and carbon trading in these markets will be globally inefficient. There is a strong need of a global agreement that allows carbon trade to prevent climate change at the least cost options. The second essay evaluates various econometric models for predicting price volatility in the carbon markets. Voluntary carbon market of Chicago is relatively more volatile; and like other financial markets, its volatility is forecasted best by a complex non-linear GARCH model. The compliance market of Europe, on the other hand, is less volatile and its volatility is forecasted best by simple econometric models like Historical Averages and GARCH and hence is different from other markets. Findings could be useful for investment decision making, and for making choice between various policy instruments. The last essay focuses on agent based models that incorporate interactions of heterogeneous entities. Artificial carbon markets obtained from such models have statistical properties - lack of autocorrelations, volatility clustering, heavy tails, conditional heavy tails, and non-Gaussianity; which are similar to the actual carbon markets. These models possess considerably higher forecasting capabilities than the traditional econometric models. Forecast accuracy is further improved considerably through experimentation, when agent characteristics like wealth distribution, proportion of allowances and number of agents are set close to the real market situations.

Keywords: Carbon markets
climate change
cointegration
market volatility
agent based models
Advisor: Kant, Shashi
Human Agency in the Interstices of Structure: Choice and Contingency in the Conflict over Roşia Montană, Romania

Sociology has long struggled with the problem of human agency in its theoretical constructions. Systematically purged from the corpus of positivist, functionalist and rational choice theories, agency has nevertheless surfaced repeatedly in empirical analyses as a constant reminder that individuals are able and willing to act in ways that are not fully explained by the dominant theories. This thesis deals with the problem of human agency by exploring a particular instance of human interaction in which the choices and actions of individuals as well as the contingencies facing them are particularly conspicuous. The example chosen as a case study is the conflict over the planned Roşia Montană gold and silver mine in Romania. As neither the supporters, nor the opponents of the planned open cast mine have managed to impose their will and determine the commencement or cancelation of the mining project, the resulting struggle was extended over more than a decade. During this period, a variety of social actors with different interests and worldviews were drawn into complex interactions with each other, thus making the trajectory and outcome of the conflict unpredictable. At the same time, there emerged an enlarged space for human agency, especially for those actors that have been usually conceived as voiceless and powerless. The origins of this space of agency are traced to the particular configuration of macro-social processes which interacted in series of highly contingent events. More exactly, none of the broad processes discussed in the literature on resource conflicts – such as accumulation by dispossession, the resource curse or unequal development – ran its full course in determining the outcomes of the conflict. The temporary suspension of overpowering structural determinations opened up a realm in which social actors could convert the contingencies of the conflict into opportunities and risks. Individuals became relatively free to make choices and influence the choices of others. The language of the sociology of translation is used as the most apt description of the fluidity of these interactions. The dynamic between the ordering and reordering of the social world of Roşia Montană through interaction is a key insight of the thesis.

Keywords: choice and contingency
Rosia Montana
Advisor: Baldus, Bernd
The Protection of Pharmaceutical Patents and Data under TRIPS and US-Jordan FTA: Exploring the Limits of Obligations and Flexibilities: A Study of the Impacts on the Pharmaceutical Sector in Jordan

In 2000, Jordan signed the Agreement on Trade-related Aspects of Intellectual Property Rights (the TRIPS Agreement) and a free trade agreement with the US (USJFTA). Both commitments have required Jordan to comply with various obligations, including full compliance with the minimum standards for the protection of intellectual property rights (IPRs) under the TRIPS Agreement and TRIPS-Plus IP standards set out under the terms of the USJFTA. Enticed by views that strong IP protection would create prosperity in the Kingdom by promoting technological innovation and inducing transfer and dissemination of technology to Jordanians, Jordan implemented the provisions of TRIPS and the USJFTA to the letter. However, Jordan focused little attention on important “TRIPS flexibilities”. In particular, Jordan has qualified parallel importation and limited the grounds of compulsory licenses. In addition, Jordan provides pharmaceutical testing data with data exclusivity. This thesis focuses on the Jordanian experience in the pharmaceutical sector. It argues that strong patent protection has not been conducive to the promotion of technological innovation and the transfer and dissemination of technology. Moreover, this protection has resulted in adverse outcomes such as increased drug prices, unavailability of essential medicines in some public hospitals for serious diseases, and a dwindling local pharmaceutical industry, in part, as a consequence of its inability to access advanced, patented technology on reasonable commercial terms. The thesis also investigates the legitimacy of establishing certain grounds of compulsory licensing by Jordan, even in light of the TRIPS-Plus obligations under the USJFTA. It advocates that such grounds contribute to the promotion of technical innovation, lead to the transfer of advanced technology, and above all improve access to affordable medicines. Finally, the thesis explores Jordan’s obligations to protect pharmaceutical testing data under TRIPS and USFTA arguing that neither of these two instruments requires data exclusivity as claimed by Pharmaceutical Research and Manufacturers of America (PhRMA) and some developed countries.

Keywords: Jordan
developing countries
TRIPS agreement
pharmaceutical patent
access to medicines
data protection
Advisor: Katz, Ariel
Ironia: metafinzione nelle opere di Luigi Malerba

Irony: metafiction in Luigi Malerba’s works. In this thesis I examine irony and metafiction in some novels by Italian writer Luigi Malerba (1927-2008). Metafiction characterizes all of Malerba’s works; this dissertation shows how Malerba’s works constantly draw attention to themselves and consequently encourage readers to pose questions about the existing relationship between fiction and reality. Similarly, irony fosters further investigation of language as sign system; through recurrent word games, Malerba removes the certainty of a univocal existing correspondence between signifier and signified. In the first chapter I discuss the very first works by the author: Le lettere di Ottavia, Il serpente, Salto mortale and Il protagonista. The entire chapter revolves around the construction of possible worlds and, therefore, of fictional worlds. Through this analysis the borders between fiction and reality appear to be quite weak; they are indeed proved to be an illusory construction of contemporary human beings who tend to think according to binary oppositions, such as reality and dream, reality and fiction. I proceed by examining Storie dell’anno mille, Il pataffio, I cani di Gerusalemme and Le maschere; these novels are imbued with history. The central theme of the entire chapter is history and fabulation and their relationship to each other. History is shown to be part of human discourse: historical events are made out of pure chronicles by a process called emplotment. The form that the historical narration takes on inevitably influences the meaning of the events narrated. In the third chapter I analyze Le pietre volanti, La superficie di Eliane and Il circolo di Granada. Here I demonstrate how Malerba uses detective novels in a non-canonical way, turning his own works into anti-detective novels. In these works, the investigation does not reach any rewarding ending; even at the conclusion of the story, the detective’s hypothesis cannot be completely ruled out and the reader is left with what Stefano Tani calls a “fiction of possibilities”. Fantasmi romani occupies the whole chapter four. In this final chapter I discuss why this work, the very last one before the author’s death, can be considered his literary testament. In this novel, Malerba’s readers can find all the peculiarities which have distinguished the author’s writing for more than four decades. Along with recognizing his style, readers will appreciate new developments in his narration. This work encourages readers to investigate the consuming relationship which can be established between a writer and his reader. In the end of this thesis, some considerations for further investigation are made; these considerations focus on Luigi Malerba’s writing for children, an area of study that has received little critical attention.

Keywords: Contemporary Italian literature
Luigi Malerba (1927-2008)
Advisor: Capozzi, Rocco
They Hasten toward Perfection: Virginal & Chaste Monks in the High Middle Ages

As perennial Christian ideals, virginity and chastity were frequent themes in medieval religious discourse. Male religious were frequently virgins and were expected to cultivate chastity; however, women not men were usually the focus of such discussions. But some monastic writers did draw on those models when considering their own spirituality, and it is worth knowing how they were understood and enlisted in those instances. To this end, I investigate five eleventh- and twelfth-century monks who wrote about monastic virginity or chastity: Anselm of Canterbury, Guibert of Nogent, Rupert of Deutz, Bernard of Clairvaux, and Ælred of Rievaulx. In my analysis, I uncover each author’s perception of virginity/chastity. Thus, I reveal that Anselm’s Deploratio is not about lost physical virginity or even sexual sin per se; it is a spiritual meditation driven by his immense fear that sinners would be forever damned. Guibert’s work exposes what a treatise on virginity could become in the hands of an adolescent struggling with sexual desire and steeped in lessons taught by his monastery. Rupert’s tract on virginity and masturbation portrays male virginity as tangible and potent. In so doing, it erects a barrier defending Rupert’s work as an exegete against detractors. For his part, Bernard teaches that what matters most is chaste humility. He also consistently links virginity with pride and false holiness, a strategy possibly linked with a battle between white and black monks. Finally, Ælred produces a model of monastic perfection that is terrifically masculine, distinctively different from virginity, and perfectly suited for his audience. In addition to uncovering each monk’s unique perception of virginity and chastity, I call attention to similarities and differences in their thought and make conclusions based on those observations. Overall, I have found not only that virginity and chastity did matter to some medieval religious men but also that the way they handle those ideals can be tremendously revealing.

Keywords: medieval
high Middle Ages
monasticism
virginity
chastity
sexuality
gender
eleventh century
twelfth century
male virginity
monastic virginity
monastic chastity
Rupert of Deutz
Guibert of Nogent
Anselm of Canterbury
Aelred of Rievaulx
Bernard of Clairvaux
adolescence
childhood
masturbation
Cistercian
Benedictine
monastic education
De institutione inclusarum
Deploratio virginitatis male amissae
Opusculum ad virginitatem
De laesione virginitatis
Advisor: Cochelin, Isabelle
Reluctant Relations: And Ethnography of 'Outreach' in a Post-apartheid City

This dissertation focuses on performance, moral practice, and self-respect in an urban South African setting. Taking as its point of departure the emergence and rapid expansion, in the 1990s and 2000s, of an outreach organization I call Jesus People Pretoria (JPP), it discusses this NGO’s attempt to create a ‘moral community’ in the post-apartheid city from the diverse vantage points of its Afrikaner leaders, its clients, and—most emphatically—its lay workers, the majority of whom are black women. Gradually moving from the everyday stage of outreach labour towards women’s gendered performances within and beyond the work environment, it proposes that at stake in the making of the JPP moral community is the negotiation of self-respect, which hinges upon the degree to which interactions imply the fostering or refutation of mutual respect, or the measure of the ‘equality’ of the exchange. As an urban entity deeply entwined in and illuminative of South Africa’s broader post-apartheid ironies, including ongoing race-based differentiation and the pervasiveness of HIV/AIDS and death, predominantly moral practice here remains but ambivalently constituted. Yet this does not denote the absence of the moral but temporarily rests it in the region of the indistinct, the unresolved, in the moment of its apparent impossibility or unachievability.

Keywords: South Africa
post-apartheid
performance
moral practice
self-respect
irony
Pretoria
NGO
Advisor: Lambek, Michael
Sanders, Todd
Elastin-like Polypeptide Enriched Surfaces for Cardiovascular Applications through the use of Bioactive Fluorinated Surface Modifiers

Currently used small diameter synthetic vascular grafts are prone to high rates of failure related to thrombosis and neointimal hyperplasia. Biomimetic materials, based on the extracellular matrix (ECM) composition of native tissues, represent an attractive solution to address these complications. The inherent low thrombogenicity and cell signalling properties of elastin-like polypeptides (ELPs) make them a suitable option for these applications. In this thesis, ELP surface modification has been achieved through the use of elastin cross-linking peptide bioactive fluorinated surface modifiers (ECP-BFSMs). The synthesis of these low molecular weight fluorinated additives was described and their subsequent blending with a base polycarbonate-urethane (PCNU) was shown to successfully enrich the surface to allow for ELP surface cross-linking. The kinetic surface migration of fluorescent ECP-BFSMs was studied over a 2 week casting period by two-photon confocal microscopy. Contact angle and x-ray photoelectron spectroscopy (XPS) confirmed the surface localization of the ECP-BFSMs. Changes in contact angle and XPS spectrums following ELP surface cross-linking confirmed the success of the surface modification approach. The novel ELP surface modified materials were demonstrated to inhibit fibrinogen surface adsorption and platelet adhesion under physiological flow conditions and inhibit bulk platelet activation following blood-material contact. Moreover, these ELP modified surfaces were shown to promote increased endothelial and smooth muscle cell adhesion, spreading and retention over a 7 day culture period relative to their non-ELP analogs. Endothelial and smooth muscle cells seeded on the elastin-like materials were shown to express endothelial nitric oxide synthase (eNOS) and smooth muscle myosin heavy chain (SM-MHC) cell specific phenotypic markers, respectively. Furthermore, competitive inhibition experiments revealed that initial smooth muscle cell adhesion to ELP surface modified materials was mediated through elastin-laminin cell surface receptors binding to VGVAPG peptide sequences on the ELP molecules. Hence, these materials may have broad applicability in cardiovascular applications, from blood contacting materials to scaffold structures for vascular graft tissue engineering. Furthermore, this surface modifying additive approach represents a versatile technique that can be custom tailored for various biomimetic applications to generate stable bioactive ECM-like surfaces retained onto a relatively inert fluorinated background.

Keywords: biomaterials
elastin-like polypeptides
Advisor: Santerre, J. Paul
Woodhouse, Kimberly A.
Exercise Rehabilitation Efficacy and Optimal Exercise Training Prescriptions for Improved Health Outcomes in People with Type 2 Diabetes

This dissertation examines the impact of exercise rehabilitation and the components of exercise prescriptions on optimizing health outcomes for people with diabetes (DM). Exercise is an accepted part of the diabetes management regime to help prevent or slow the progression of the disease. A combined aerobic and resistance training protocol is the recommended exercise regime for people with DM, but the question remains as to what the optimal dose may be for glycemic control and reduction of cardiovascular risk. This thesis aims to address three objectives surrounding optimal exercise prescriptions for diabetes: 1) To investigate aerobic exercise prescription efficacy in people with DM, coronary artery disease (CAD) and both CAD and DM to determine if there are population-specific VO2peak responses to exercise prescription; 2) To determine the optimal volume and intensity of resistance training exercise, in combination with aerobic training, that may improve glucose control, cardiovascular risk factors and body composition in people with type 2 DM (T2DM); and 3) To study the relationship between exercise performance, physiological changes and depressive mood in people with T2DM participating in a supervised, exercise program. Encouraging participation in an appropriately prescribed aerobic and resistance training program may help to improve adherence to exercise and elicit optimal health outcomes in people with T2DM. Tailoring the exercise prescription to suit the patient’s lifestyle, history and capacity is the utmost challenge for health care providers who hope to provide a complementary, non-pharmacologic therapeutic option for their patients.

Keywords: diabetes
exercise
aerobic fitness
glycemic control
Advisor: Thomas, Scott
Oh, Paul
Developmental Expression, Function, and Regulation of Multidrug Resistance in the Mouse Placenta and Fetal Brain

During pregnancy, 64-96% of women take at least one prescription drug. The placenta is the primary barrier between substrates in maternal and fetal circulation. The blood-brain barrier (BBB) acts as an additional barrier for the fetal brain, which is particularly susceptible to the effects of xenobiotics. Multidrug resistance phosphoglycoprotein (P-gp; encoded by Abcb1 mRNA) and breast cancer resistance protein (Bcrp1; encoded by Abcg2 mRNA) are efflux transporters localized on placental syncytiotrophoblast and capillary endothelial cells of the BBB. Placental Abcb1/P-gp and Abcg2/Bcrp1 limit maternal-fetal transfer of endogenous and exogenous substrates. Similarly, the neuroprotective roles of Abcb1/P-gp and Abcg2/Bcrp1 in the adult BBB have been demonstrated. However, developmental changes in expression and function and regulation of Abcb1/P-gp and Abcg2/Bcrp1 in these tissues are poorly understood. This thesis investigates gestational changes in expression and function of Abcb1/P-gp and Abcg2/Bcrp1 in the placenta and fetal brain, in addition to regulation by steroids, progesterone and glucocorticoids. The effects of glucocorticoids on Abcb1/P-gp and Abcg2/Bcrp1 in the placenta and fetal brain are of importance given that 10% of pregnant women are treated with synthetic glucocorticoids during the management of threatened preterm labour. These studies demonstrate that the decrease in placental Abcb1/P-gp mediated fetal protection near term is compensated by an increase in Abcb1/P-gp and Abcg2/Bcrp1 mediated neuroprotection in the fetal brain; likely in preparation for life ex-utero. The lack of effects of progesterone and the dose-, age- and sex- dependent regulatory effects of synthetic glucocorticoid have highlighted the complexity associated with regulation of these transporters. Further, these studies are the first to report sexually dimorphic glucocorticoid effects on Abcb1/P-gp and Abcg2/Bcrp1 expression and function, with the female fetus being particularly susceptible to glucocorticoid these effects. In this regard, Abcb1/P-gp and Abcg2/Bcrp1 transport capacity may be altered when synthetic glucocorticoid is administered as a co-therapy, and as such, recipient sex should be considered during pharmacotherapy. Understanding the regulation of Abcb1/P-gp and Abcg2/Bcrp1 expression and function in the placenta and fetal brain during normal development and under pathological conditions is critical for fetal health and development, particularly when therapeutic strategies are utilized in pregnancy.

Keywords: Multidrug Resistance
Placenta
Blood-brain barrier
Glucocorticoids
Progesterone
Development
Advisor: Matthews, Stephen