VictorJuiz/thesis huggingface dataset:
Citizens, Complexity and the City Lessons from Citizen Participation in Urban (Transport) Planning in Santiago Chile, 1997-2012

Abstract Twentieth century, citizen “revolts” against highway projects have influenced thinking about public transport (Toronto, Vancouver, New York), governance (Portland), and cycling (The Netherlands) to this day. Less is known about how these emerge in developing countries, and what they can tell us about citizens’ role in innovation to achieve more socially just, good and livable cities.  Using a complexity-based approach, this dissertation explores lessons from an anti-highway movement in Santiago, Chile (1997), which challenged authoritarian planning paradigms inherited from the Pinochet regime (1973-1990). In 2000, these leaders of diverse communities founded a citizen institution, Living City (Ciudad Viva), which today is a prize-winning, citizen-led planning institution.  Participation is recognized as important to community development, health and urban planning. Nonetheless, a rich literature notes many limitations. Is improving participation just a matter of “getting the process right”? Or does it require re-formulating frameworks to redistribute power, fostering self-generating civil society organizations, and treating democratization as ongoing rather than a “steady state”?  Re-formulating frameworks has far-reaching implications. It requires acting consistently with the premise that the local is central to change in human living systems, and the need to create the civic “infrastructure” conducive to citizen learning and the emergence of multiscalar citizen organizations, able to mobilize ecology of actors for innovation. To effectively address the challenges of climate change, loss of biodiversity, the social determinants of health, the “obesity epidemic” and other issues, the answers lie in city neighbourhoods and human settlements.  If we aspire to good, just and livable cities, uncertain futures require planning for change. This research suggests that we can identify dynamics likely to leverage significant change and activate capacities throughout a system. This requires moving to an inclusive planning paradigm that fully integrates citizen planners.

Keywords: active citizenship
anti-highway coalition
citizen participation
urban planning
transport planning
complexity
Advisor: Sorensen, Andre
Bayesian Inference for Bivariate Conditional Copula Models with Continuous or Mixed Outcomes

The main goal of this thesis is to develop Bayesian model for studying the inﬂuence of covariate on dependence between random variables. Conditional copula models are ﬂexible tools for modelling complex dependence structures. We construct Bayesian inference for the conditional copula model adapted to regression settings in which the bivariate outcome is continuous or mixed (binary and continuous) and the copula parameter varies with covariate values. The functional relationship between the copula parameter and the covariate is modelled using cubic splines. We also extend our work to additive models which would allow us to handle more than one covariate while keeping the computational burden within reasonable limits. We perform the proposed joint Bayesian inference via adaptive Markov chain Monte Carlo sampling. The deviance information criterion and cross-validated marginal log-likelihood criterion are employed for three model selection problems: 1) choosing the copula family that best ﬁts the data, 2) selecting the calibration function, i.e., checking if parametric form for copula parameter is suitable and 3) determining the number of independent variables in the additive model. The performance of the estimation and model selection techniques are investigated via simulations and demonstrated on two data sets: 1) Matched Multiple Birth and 2) Burn Injury. In which of interest is the inﬂuence of gestational age and maternal age on twin birth weights in the former data, whereas in the later data we are interested in investigating how patient’s age aﬀects the severity of burn injury and the probability of death.

Keywords: Conditional Copula Model
Bayesian Inference
adaptive Markov chain Monte Carlo
cubic spline
mixed outcomes
deviance informtaion criterion
cross-validated marginal log-likelihood criterion
additive model
Advisor: Craiu, Radu V.
Open and Shut

Open and Shut Fiona M. Ryan Doctor of Musical Arts Graduate Department of Music University of Toronto 2013 Abstract “Open and Shut” is a short opera in two scenes composed with concert opera performances in mind; it could be performed with or without staging. There are five characters in this work. The protagonist is Bridget (Soprano). In the first scene Bridget encounters Martha (Soprano) and Rose (Mezzo Soprano), two fundamentalist Christians who are handing out religious pamphlets on the street. In the second scene Bridget meets her friends Frank (Tenor) and Paul (Baritone) in a café and tells them of her encounter with these two women (Martha and Rose); a heated discussion of religion ensues. Each character is represented by a distinctive style of music that fits with their personality and ideology. Martha's music and singing style is inspired by Baroque and Classical sacred music (well suited to a coloratura voice) to represent her traditional and authoritarian viewpoint: the instrumentation for her music is similar to a Baroque orchestra (strings, oboe, bassoon, and sometimes brass). Rose's music is inspired by traditional folk hymns and spirituals to represent both her traditional ideals and her earnest simplicity: her vocal lines feature repetition and gospel-inspired inflections, she is accompanied by textures featuring piano, bass, and flute. Frank is an opinionated, cynical atheist whose music is atonal (flexibly based on 12 tone procedures) and is filled with harsher chords and jagged melodies to represent his modern but rigid view; his vocal lines are often paired with cello. Paul is a hippie who supports people exploring spirituality, but is opposed to institutions; Paul's music is based on use of non-traditional modes and aleatoric principles with an emphasis on the interaction of percussion and voice. Bridget is caught between all of these worlds so her music is an intuitively composed fusion of tonal, modal, and atonal styles; Bridget's individuality is represented by a recognizable melodic theme (introduced at measure 41 and repeated throughout the piece by alto flute, viola, clarinet, and piano). Additionally, each scene starts with music inspired by the sounds of a city.

Keywords: Music
Opera
Score
Advisor: Chan, Ka Nin
Spiritual African and Africentric Leadership for Social Justice:Understandings, Experiences and Spiritual Influences

The imprint of spiritual African and Africentric educational leadership is deeply entwined in the struggle over education and educational spaces. Despite this robust and contentious history, research pertaining specifically to spiritual African and Africentric educational leaders is noticeably miniscule within the field of educational leadership. This discrepancy is alarming when one considers how spiritual African and Africentric leaders have been actively involved in shaping the nature and quality of education within various contexts. This dissertation explores the conceptions and experiences of spiritual African and Africentric leaders and the function of spirituality within leaders’ practices toward social justice. Based on qualitative interviews with 10 school- and community-based participants, this research deliberately centres the perspectives of individuals who proclaim the spiritual as a natural and transformative force within their personal and professional lives. Furthermore, the present research study offers an informed understanding of African and Africentric spiritualities within the context of educational leadership for social justice and outlines the meanings, influences and tensions which participants believe to entwine the task of leading. The practice of spiritual African and Africentric leadership arises in opposition to the threat of racialization and against barriers which restrict a more inclusive understanding of education. Narratives construct leadership for social justice as an indigenous and embattled endeavour imbued with tensions, risks and prohibition. Spiritual African and Africentric leaders understand and experience their practice beyond the rudiments of functionality as leaders respectfully enter into the arena of leadership with a concern towards instituting individual, communal and systemic change. Leadership endeavours contest marginalization, initiate inclusive engagement and strategically reconstruct education within a more democratically just space. Moreover, participants depict spiritual African and Africentric leadership as a hopeful and relationally influential undertaking.

Keywords: educational leadership
critical spirituality
Africentric
African
social justice
leadership for equity
community educational leadership
school-based leadership
integrative antiracism
leadership for social justice
spiritual leadership in schools
spirituality
Africentric educational leadership
equity in schools
democratic schooling
African educational leadership
critically just leadership
Black educational leaders
inclusive education
Advisor: Portelli, John P.
Portrait of Moral Agency

Over the past several decades, secular schools in North America have been expected to impart moral education to students. An array of approaches, strategies, methods, and philosophical and theoretical orientations for doing so are promoted in education literature. Two, in particular, have also been politically endorsed in Ontario, Canada—character education and community service. Yet, there remains discrepancy among teachers’ practices, knowledge, awareness, and intentions. Anecdotal reports indicate that relatively few teachers provide a consistent and comprehensive moral education, and those who do, act primarily on their own initiative and at their own discretion. Previous empirical evidence suggests that teachers who are moral agents conceive of, enact, and reflect on a personally developed form of moral education, which is embedded in the moral and ethical dimensions of school and classroom life, curriculum, and pedagogy. This single-case study aims to broaden and deepen the scholarship of moral agency as moral education, by exploring the question How does a teacher, who prioritizes the moral education of students, envision, enact and reflect on that moral education. Positioning myself as a conduit, within what is often considered to be a closed-door culture of teaching, I metaphorically opened one teacher’s classroom door and exposed her practices. The result is a uniquely comprehensive and genuine portrait of moral agency, which details the use of a variety of strategies and methods for imparting morality. These include intentionally modelling moral behaviours, conduct and dispositions; fostering relationships with and among students; creating a classroom community; delivering virtues lessons and messages; encouraging discussions of a moral nature; nurturing self-discipline in students; providing opportunities for community service; and assessing students’ social and moral development. The harmonious co-existence of these strategies and methods within one classroom and one teacher’s practice; the complementary and supportive way in which the teacher makes use of them; and their independence of any particular philosophical or theoretical orientation for moral education, represent the main insights of this study. These insights suggest that moral education in a secular classroom might be more comprehensively understood and promoted as moral agency.

Keywords: moral education
moral agency
moral dimensions of teaching
teaching morality
micro ethnography
single-case study
teaching morally
Advisor: Campbell, Elizabeth
Effects of Chronic Oxidative Stress on TRPM2 and TRPC3 Channels: Potential Implications for Bipolar Disorder

Intracellular calcium and oxidative stress dyshomeostasis, which can be highly interactive, occur in bipolar disorder (BD), but the pathogenesis of these disturbances is unknown. The transient receptor potential (TRP) melastatin subtype 2 (TRPM2) and canonical subtype 3 (TRPC3) calcium-permeable non-selective ion channels, already implicated in BD, are involved in calcium and oxidative stress signalling. Thus, I sought to determine whether the expression and function of these channels are modulated by oxidative stress exposure in rat cortical neurons, astrocytes, and in human B lymphoblast cell lines (BLCLs), a cell model that reports diagnostically relevant abnormalities in BD. This thesis work demonstrated that TRPC3 expression and function are decreased after chronic, but not acute oxidative stress exposure in both human and rat cell models. TRPM2 expression, on the other hand, was increased after both acute and chronic stressor treatments in rat cortical neurons. In BLCLs, TRPM2-mediated calcium entry was blunted although no difference in TRPM2 mRNA expression was detected. Moreover, BLCLs from BD-I patients exhibited greater susceptibility to cell death and a differential sensitivity of TRPM2-mediated calcium influx to acute oxidative stress compared with healthy subjects, further supporting reduced cellular resilience in the pathophysiology of BD-I. I also demonstrated that TRPC3 protein is expressed in human brain from 8 days to 83 years old supporting an ongoing role in the developing and adult human brain. These findings support an important role for TRPM2 and TRPC3 in sensing and responding to oxidative stress, and in transducing oxidative stress signalling to intracellular calcium homeostatic and cellular stress responses, which have been implicated in the pathophysiology of BD. Finally, this work has highlighted an inherent difference in TRPM2 channel functionality in BD type I subjects compared with controls, adding functional evidence to the genetic and differential expression findings implicating TRPM2 dysfunction in BD.

Keywords: Transient receptor potential channels
Bipolar disorder
Calcium signalling
Oxidative stress
Advisor: Warsh, Jerry
Embracing Incompleteness in Schema Mappings

Various forms of information integration have become ubiquitous in current Business Intelligence (BI) technologies. In many cases, the semantic relationship between heterogeneous data sources is specified using high-level declarative rules, called schema mappings. For decades, Skolem functions have been regarded as an important tool in schema mappings as they permit a precise representation of incomplete information. The powerful mapping language of second-order tuple generating dependencies (SO tgds) permits arbitrary Skolem functions and has been proven to be the right class for modeling many integration problems, such as composition and correlation of mappings. This language is strictly more powerful than the languages used in many integration systems, including source-to-target and nested tgds which are both first-order (FO) languages (commonly known as GLAV and nested GLAV mappings). An important class of GLAV mappings are Local-As-View (LAV) tgds, which has found important application in data integration. These FO mapping languages are known to have more desirable programmatic and computational properties. In this thesis, we present a number of techniques for translating some SO tgds into equivalent, more manageable FO schema mappings. Our results rely on understanding and controlling the presence of incompleteness in mappings. We show that the composition of LAV mappings is not only FO, but can always be expressed as a LAV mapping. As a byproduct, we show that the problem of recovery checking for LAV mappings becomes tractable, in contrast to the case of GLAV mappings for which it is known to be undecidable. We introduce two approaches for transforming SO tgds into equivalent nested GLAV mappings. Our approach considers the presence of source constraints, and provides sufficient conditions for when the rich Skolem functions in SO tgds are well-behaved and have an FO semantics. We experimentally show that these conditions are able to handle a very large number of real schema mappings. Last, we propose a first-step for embracing incompleteness in the context of BI applications. Specifically, we present elements of a formal framework for vivifying data with respect to a business model. We view the task of discovering data-to-business interpretations as one of removing incompleteness from these mappings.

Keywords: Data Integration
Data Exchange
Schema Mappings
Incompleteness
Skolem Functions
UnSkolemization
Vivification
Advisor: Miller, Renee J.
Mylopoulos, John
The Pleiotropic Roles of FGLamide Allatostatins in the African Migratory Locust, Locusta migratoria

The FGLa/ASTs are one family of allatostatin peptides and share an amidated C-terminal sequence (FGL-amide). The inhibitory effect of FGLa/ASTs on juvenile hormone (JH) biosynthesis in Diploptera punctata led to their discovery, but there is a lack of allatostatic function across most insect species that suggests this function may not be their primary role. Rather, the FGLa/ASTs are implicated as brain/gut peptides, modulating gut physiology. This thesis demonstrates the pleiotropic nature of FGLa/ASTs in Locusta migratoria and emphasizes the role of FGLa/ASTs as brain/gut peptides involved in homeostatic processes. FGLa/AST-like immunoreactivity (FLI) is associated with the corpus cardiacum (CC) and corpus allatum (CA). FGLa/ASTs increase adipokinetic hormone release from the CC and alter JH biosynthesis from the CA, suggesting roles in energy utilization and in growth and metamorphosis. Each region of the gut exhibits FLI. The gut is dually innervated: neurons in the abdominal ganglia of the central nervous system (CNS) innervate the posterior gut and some contain FLI, while neurons within the stomatogastric nervous system (STNS) that innervate the anterior gut do not seem to contain FLI, indicating that source of FLI on the gut are cells within the CNS, which may release FGLa/ASTs at the gut to alter aspects of gut physiology. FGLa/ASTs are involved in peristalsis, neural control of foregut contractions, and ileal K+ transport. In particular, FGLa/ASTs inhibit contractions of each gut region and also modulate the rhythmic motor output of a central pattern generator within the ventricular ganglion of the STNS. FGLa/ASTs also inhibit ileal K+ efflux, suggesting a diuretic action and implicating FGLa/ASTs in fluid and ion homeostasis. This work provides a comprehensive picture of how FGLa/ASTs play an integral role in nutrient processing, energy mobilization, and growth and metamorphosis to contribute to the overall maintenance of homeostasis. This reinforces the role of FGLa/ASTs as brain/gut peptides and emphasizes their involvement in the flexibility of nervous communication and integration of the endocrine system with the CNS to achieve homeostasis.

Keywords: Allatostatin
Neuropeptide
Gut physiology
Hormone release
Ion transport
FGLa/AST
muscle contraction
Locusta migratoria
Advisor: Lange, Angela
The Role of Fungal Stress Responses in Regulation of Azole Resistance

Fungal pathogens are a leading cause of human mortality, at least in part due to their ability to thwart therapeutic regimens by rapidly evolving resistance to antifungal drugs, and as a consequence of the increasing frequency of immunocompromised individuals most vulnerable to fungal infection. Candida albicans, the leading human fungal pathogen, has evolved an elegant repertoire of mechanisms to survive the cellular stress exerted by the azoles, which are the most widely deployed class of antifungals and inhibit ergosterol biosynthesis, inducing cell membrane stress. The evolution and maintenance of diverse resistance phenotypes is contingent upon cellular stress response circuitry, including that regulated by the molecular chaperone Hsp90 and its client protein calcineurin. My doctoral research focuses on three aspects of the role of fungal stress responses in regulation of azole resistance. First, I establish a novel role for nutrients and nutrient signalling in azole resistance of C. albicans and the model yeast Saccharomyces cerevisiae. Compromising a global regulator that couples growth to environmental cues, Tor kinase, provides a powerful strategy to abrogate fungal drug resistance with broad therapeutic potential. Second, I implicate the molecular chaperone Hsp90 as a key regulator of biofilm drug resistance in C. albicans. Compromising Hsp90 function transforms the azoles from ineffective to highly efficacious at eradicating biofilms in vitro and in vivo. Depletion of Hsp90 leads to reduction of client proteins’ calcineurin and Mkc1 in planktonic but not biofilm conditions, suggesting that Hsp90 regulates drug resistance through different mechanisms in these distinct cellular states. Third, I establish that inhibition of lysine deacetylases (KDACs) blocks the emergence and maintenance of Hsp90-dependent azole resistance in C. albicans and S. cerevisiae. S. cerevisiae Hsp90 is acetylated on lysine 27 and 270, and key KDACs for drug resistance are Hda1 and Rpd3. Compromising KDACs alters stability and function of Hsp90 client proteins, including drug resistance regulator calcineurin. Overall, this work provides novel insight into the mechanisms by which cellular stress responses mediate azole resistance, and establishes acetylation as a novel mechanism of post-translational control of Hsp90 function in fungi; ultimately, this unveils numerous targets that could be exploited for therapeutic benefit in the treatment of fungal disease.

Keywords: antifungal
Candida albicans
Hsp90
acetylation
Advisor: Cowen, Leah
Search for New Phenomena with the Mono-jet Signature, and a Direct Measurement of the Z Boson Invisible Width, with the ATLAS Detector at the CERN Large Hadron Collider

A search for new physics in events with an energetic jet and large missing transverse momentum is performed with the ATLAS detector, using 2011 dataset corresponding to 4.7 fb−1 integrated luminosity. A model–independent approach is adopted, making predictions in various kinematic regions sensitive to potentially new physics scenarios. Data–driven background determination methods are developed to obtain robust predictions of the Standard Model expectations of the number of events in each probed kinematic region. No deviation from the Standard Model expectation is observed, and the results are hence interpreted in the context of the ADD scenario of Large Extra Dimensions, and pair production of WIMP dark matter candidates. This results in the world’s tightest constraints on the size of the D-dimensional Planck scale as the fundamental parameter of the ADD theory. The constraints obtained on Dark Matter suppression scale are stronger than those obtained from dedicated direct and indirect dark matter experiments for a large range of WIMP masses. Furthermore, data-driven estimates of various Standard Model processes contributing to the mono-jet final state allows a precise direct measurement of the invisible decay width of the Z boson. This results in a measurement at 5% precision level, comparable to the results of the L3 experiment, and better than all other LEP direct measurements.

Keywords: ATLAS
LHC
Advisor: Orr, Robert S.