VictorJuiz/thesis huggingface dataset:
British perceptions of the Ottoman Empire, 1876-1908

The title of this thesis is 'British Perceptions of the Ottoman Empire (1876-1908). The thesis explores the 'cultural dimension1 of relations between the Ottoman Empire and Britain in this period, involving an examination of ideas about and representations of Ottoman society and its peoples. The overall aim is to stress the importance of these representations in in influencing and affecting relations between Britain and the Ottoman Empire.
Nineteenth-century writings about the Ottoman Empire produce strong images of Ottoman society and steroetypes of the Turkish and Christian populations. These images are reconstructed and their significance examined. The approach is contextual and perceptions are analysed in the historical, material and cultural framework of late Victorian Britain. Descriptions of Ottoman society are treated as representations of that complex reality, with varying degrees of accuracy and inaccuracy, reflecting or distorting conditions in the Empire. In addition the relationship between older ideas and ideas developing at a new historical conjuncture of late nineteenth-century imperialism are considered important factors in determining the overall image of the Ottoman Empire in the late Victorian mind.
In these ways the conclusion stresses the importance of, and the relationship between ideas about the Ottoman Empire, and the concrete factors of inter-state relations of which they are part. As such the subject contributes to an understanding of the multi-dimensional nature of nineteenth-century relations between a weak and strong state in the International system, and the degree to which culture and ideas are informed by these relationships of power. The study contributes to a greater understanding of the Eastern question and sheds light on many of the ideas that have come to influence modern historiography about the Ottoman past and the appreciation of Ottoman and European diplomatic history.
Using commensals as proxies for historical inference in the Indian ocean: genetic and zooarchaeological perspectives

The human-abetted introduction of commensal species (i.e. those that opportunistically exploit the anthropogenic environment for food and shelter, e.g. rats, cockroaches etc.) to new areas has occurred throughout history. This has resulted in detrimental ecological changes worldwide but, from a viewpoint of human knowledge, a beneficial corollary of these translocations is that the species in question can be used as proxies to study the movement of the humans who transported them. I reconstruct colonisation histories of three widespread commensal mammalian species in the Western Indian Ocean, the black rat Rattus rattus, house mouse Mus musculus and Asian house shrew Suncus murinus, through phylogeographic studies (the geographic distribution of genetic lineages) of maternally-inherited mitochondrial markers, and zooarchaeological data. The DNA analyses are conducted on samples largely derived from museum specimens collected up to 110 years ago, and from archaeological bones (in the case of rats). I show considerable cryptic diversity in all three species, particularly in mice for which we find a potential major new lineage. Certain lineages within each species predominantly reveal long-distance translocations within the Indian Ocean, but high resolution geographic and genetic clustering is also evident, particularly in Asian house shrews. Phylogeographic structuring of the three species in East Africa and the southern Indian Ocean region (e.g. Madagascar, Reunion, etc.) indicate connections with Arabia, the Middle East, and India in the Islamic period from the first millennium AD, and later European connections during the Age of Exploration. Closer to the origins of the three species (the Indian subcontinent in all cases), range expansions in Eurasia and nearby islands relate to early to mid Holocene human populations, but also with signals of later secondary colonisations. Through ancient DNA studies I found genetic continuity between temporally separated populations of black rats suggesting population persistence, and high levels of diversity in Songo Mnara, a Swahili stonetown in Tanzania. Knowledge of the colonisation history and genetic diversity of an introduced species is essential to understand their resilience in novel landscapes, and to identify pathways of invasion and, by proxy, human trade and exchange networks that facilitated their dispersal. My research contributes significantly to that end for three socially, economically and ecologically important species that are well-established in the Indian Ocean region and beyond.

Keywords: Rattus rattus
Phylogeography
Mus musculus
Indian Ocean
Suncus murinus
Advisor: Boivin, N
Searle, J
Engineering the surface properties of microbubbles for biomedical applications

Surfactant coated microbubbles are widely used as contrast agents (UCA) in medical ultrasound imaging, due to their high echogenicity and non-linear response to acoustic excitation. Controlling the stability of microbubbles in vivo represents a considerable challenge. Understanding the characteristics of the bubble surface and how they change with production method, composition and environment is key to addressing this problem. The aim of this thesis is to investigate viscosity, bubble dissolution, and acoustic response as functions of their composition, manufacturing method and environment.
Bubbles were made using combinations of phospholipid and an emulsifier in different molar ratios. Adding the emulsifier decreased both the size and the surface viscosity of the bubbles and caused changes in the scattered pressure amplitude of bubbles under ultrasound.
To increase microbubble stability, solid inorganic nanoparticles were adsorbed on to the microbubble surface. These particles behaved as Pickering stabilisers, and deterred Ostwald ripening. The nanoparticles also enhanced the nonlinear behaviour of bubbles at low acoustic pressures.
Three manufacturing methods (sonication, cross-flow and flow focusing) were investigated in order to verify stability differences. Sonication produced bubbles with surface viscosities hundreds of centipoise greater than those produced by microfluidics. Both pressure amplitude and harmonic content for sonicated bubbles were found to be much larger due to a higher liposomal adhesion rate at the surface.
Solution temperature and bubble age were also investigated. When the solutions were heated above the phospholipid gelling temperature, microfluidic bubbles showed an increased surface viscosity, due to increased liposome adhesion caused by the increased temperature.
Bubble composition, manufacturing method and environment were found to vary the surface characteristics of the microbubbles. Further investigations into the affects of the filling gas, in vitro studies, and low temperature TEM characterisation should be conducted to produce a microbubble with the full range of desired characteristics.

Keywords: bubbles
microfluidics
membranes
ultrasound
Advisor: Stride, E
Investigation into the regulatory mechanism of BRCA2 stability

Inherited mutations in the BRCA2 gene predispose individuals to the development of breast and ovarian cancers. The BRCA2 protein plays a fundamental role in the repair of DNA double strand breaks by homologous recombination (HR). BRCA2 mediates the recruitment of the RAD51 recombinase to DNA damage sites, which in turn promotes homologous pairing and strand exchange during HR.
It has been reported that increased BRCA2 mRNA levels correlate with poor cancer prognosis, and recently it has been shown that increased levels of BRCA2 suppress HR. As HR is regulated through the cell cycle and can only be employed during S and G2 phases of the cell cycle, in this study, the cell cycle-dependent regulation of BRCA2, as a key player of HR, was investigated.
In this study I report that BRCA2 stability is regulated by the ubiquitin-proteasome system (UPS), which has become increasingly evident as an important regulator of DNA repair. In line with this, I found that BRCA2 can be ubiquitylated in vivo and that it interacts with proteins of the UPS. Interestingly, I observed that BRCA2 levels and its ubiquitylation status change during the cell cycle. Using a siRNA-based approach, I identified a candidate E3 ubiquitin ligase, the SCFFBXW7 complex, which is also a known major cell cycle regulator. siRNA-mediated knockdown of FBXW7 led to stabilization of BRCA2 and overexpression of FBXW7 resulted in BRCA2 ubiquitylation in vivo. Furthermore, I have refined the regions that the SCFFBXW7 interacts with on BRCA2, which likely occurs in a phosphorylation-dependent manner.
Taken together, these observations suggest that BRCA2 stability is regulated by the UPS in a cell cycle-dependent manner, which may be an important regulatory mechanism for BRCA2 function.

Keywords: APC/C
Ubiquitin
F-box proteins
cell cycle
SCF
BRCA2
DNA damage
Advisor: Esashi, F
Developments in social evolution and virulence in parasites

The study of social evolution and virulence in parasites is concerned with fitness consequences of trade-offs between parasite life history traits and interactions between parasite species and/or genotypes with their hosts. I develop our understanding of social evolution and virulence in parasites in several ways. (1) I review empirical evidence for the fundamental predictions of virulence-transmission trade-off theory and demonstrate that the fit between theory and data is primarily qualitative rather than quantitative; that parasites differ in their degree of host generalism, and this is likely to impact virulence in four ways. (2) I take a comparative approach to examine the underlying causes of an observed statistical variation in the size of parasite infectious doses across taxa, revealing that mechanisms used by parasites to infect hosts are able to explain variation in both infectious dose and virulence. (3) I formally compare data on human pathogens to explain variation in virulence across taxa, revealing that immune subversion and not growth rate, explains variation in virulence. This allows me to predict that immune subverters and not fast growing parasites are likely to cause the most virulent clinical infections. (4) Using bacteria and their naturally infecting viruses (bacteriophage), I take an experimental approach to investigate the consequences of coinfection for parasite life history traits, and find that viruses cultured under a mix of single infections and coinfections evolved plasticity; they killed hosts more rapidly when coinfecting, and this resulted in high fitness under both single infection and coinfection conditions. (5) I experimentally investigate how selection within and between hosts and patches of hosts affects the fitness and virulence of populations of these viruses. I find that limited host availability favours virulent, faster killing parasites with reduced transmission; suggesting high, rather than low, virulence may be common in spatially structured host-parasite communities.

Keywords: phage
parasites
bacteria
evolution
virulence
social behaviour
Advisor: West, S
Buckling, A
The body of God in word, world and sacrament:

This thesis is a comparative study that focuses on the writings of an Oxford-trained Indian Christian theologian, priest and Bishop named A.J. Appasamy (1891-1975), and his theological interaction with the texts and tradition of the Srivaiṣṇava reformer Rāmānuja (1017-1137). For my doctrinal focus I have chosen to explore Appasamy’s four-fold Johannine application of the ‘Body of God’ analogy - the ‘Universe’, ‘Incarnation’, ‘Eucharist’ and ‘Church’ being his four divine embodiments. Post-Independence, Appasamy faced criticisms from expatriate theologians who described his theological project as ‘bold heresies’, a ‘synthesis of Christianity and Vedanta’ that has ‘shifted the axis’ from Christianity to ‘Hindu religion’. By following the leads in Appasamy writings back to his devotional tradition, I argue that such charges are, in fact, baseless and that his application of the analogy is rooted, rather, in the sacramental theology of his own Anglican tradition. To do so I demonstrate how his views on divine embodiment closely reflect the theological developments that took place in the first half of the last century between the time of Charles Gore and William Temple. Methodologically, I am arguing for the need to understand theological discourse as being semiotically and traditionally situated, embedded in mythic narrative and embodied in ritual practice. In doing so, however, I further argue that just as Appasamy’s detractors have failed to read him in the context of his devotional tradition, so, too, has Appasamy done with Rāmānuja. By reading Rāmānuja more as a Vedāntic philosophical theologian than as a sectarian practitioner, he has abstracted the Ācārya from his tradition - a tradition that is undoubtedly temple-based. On this basis I challenge Appasamy’s use of Rāmānuja’s terms and propose what I believe to be a better reading of John’s Gospel for future comparative interaction with the Srivaiṣṇava tradition.

Advisor: Edwards, M
Flood, G
British politics and the post-war development of human rights

In this thesis I explore the attitudes, arguments, and actions of British political elites in connection with the development of human rights law in Europe and the UK. I do this by examining British input into five key episodes for the development of European supranational rights and their incorporation into domestic legal orders (namely the drafting of the European Convention on Human Rights 1950, the drafting of the European Social Charter 1961, the acceptance of individual petition in 1966, the failed 1970s Bill of Rights debate, the passing of the Human Rights Act 1998, and recent developments such as the UK ‘opt-out’ to the EU Charter of Fundamental Rights, and the emergence of a new ‘British Bill of Rights’ debate). Casting light on British involvement in less examined periods in European rights development, I challenge existing, isolated, explanations for the more focal episodes (such as Simpson’s rational-choice post-colonial thesis for individual petition acceptance, and ideological accounts for New Labour’s post-1997 constitutional reform). Responding to the most recent literature in the area, central to my analysis is the question of how rights progress relates to inter-party conflict. By considering continuities and discontinuities in elite political discussion of rights I argue that while conflict is a significant underlying feature of every major episode of rights progress during the last sixty years, and is less evident in less progressive periods, other factors have had a greater influence over the form, timing, and extent of rights progress. Most significant amongst these is the constitutional ideological development of the Labour party and the critical connection between Labour’s elevation of the Convention within the UK constitutional space and revisionist shifts in party thinking.

Keywords: Conservative Party History
Labour Party History
UK Constitutional Reform
European Human Rights Development
Human Rights
British Political History
Human Rights History
Advisor: Erdos, D
Galligan, D
Heart valve tissue engineering

Since current prosthetic heart valve replacements are costly, cause medical complications, and lack the ability to regenerate, tissue-engineered heart valves are an attractive alternative. These could provide an unlimited supply of immunological-tolerated biological substitutes, which respond to patients' physiological condition and grow with them. Since collagen is a major extra cellular matrix component of the heart valve, it is ideal material for constructing scaffolds.
Collagen sources have been shown to influence the manufacturing of collagen scaffolds, and two commercial sources of collagen were obtained from Sigma Aldrich and Devro PLC for comparison. Consistencies between the collagens were shown in the primary and secondary structures of the collagen, while inconsistencies were shown at the tertiary level, when a higher level of natural crosslinking in the Sigma collagen and longer polymer chains in the Devro collagen were observed. These variations were reduced and the consistency increased by introducing crosslinking via dehydrothermal treatment (DHT).
Collagen scaffolds produced via freeze-drying (FD) and critical point-drying with cross-linking via DHT or 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide /N-hydroxysuccinimide (EDC/NHS) were investigated. All the scaffolds were compatible with mesenchymal stem cells (MSCs) according to the proliferation of the cells and their ability to produce ECM, without differentiating between osteogenic, chondrogenic or endothelial lineages. The FD EDC/NHS scaffold demonstrated the most suitable physical property of all. This result illustrates that FD EDC/NHS crosslinking is the most suitable scaffold investigated as a start for heart valve tissue engineering.
To prepare a scaffold with a controlled local, spatial and temporal delivery of growth factor, a composite scaffold comprising poly (lactic-co-glycolic acid) (PLGA) microspheres was developed. This composite scaffold demonstrated the same compatibility to the MSCs as untreated scaffold. However, the PLGA microspheres showed an increase in the deterioration rate of Young's modulus because of the detachment of the microspheres from the scaffold via cellular degradation.

Keywords: Heart valve
PLGA microspheres
drug release
tissue engineering
mechanical property
Mesenchymal stem cells
scaffold
collagen
Advisor: Czernuszka, JT
bHLH and bHLH-LZ factor exchange at promoters

Mammalian promoters often contain DNA-elements that can be bound by a number of closely related transcription factors (TFs) that cannot bind to the same DNA-element simultaneously. It is possible that each TF responds to distinct cues, allowing the gene to be activated in response to multiple stimuli. An alternative possibility is that each TF binds sequentially, each contributing to the pre-initiation events leading up to transcription.
Here, we explore the exchange of basic-Helix-Loop-Helix-Leucine-Zipper (bHLH-LZ) factors, USF1, USF2 and MITF at the TYROSINASE promoter following induction by UVB-irradiation and methotrexate-administration. We demonstrate, for the first time in human melanoma, differential induction kinetics of TYROSINASE gene in response to an initial or re-induction, a phenomenon akin to "transcription memory" previously described in yeast.
We also show that USF2, specifically detected by two different antibodies targeting the N-terminal region, is largely cytoplasmic, at least in the cell lines we have investigated. We also showed that nucleo-cytoplasmic shuttling of these USF2 species is partly regulated by glucose. Using deletion mutants, we demonstrated the requirement of the amino-acids surrounding the USF-specific region and the basic domain in nuclear localisation of USF2, and that amino-acids 1−193 appear to enhance dimerization of USF2 in addition to the classical HLH-LZ dimerization domain.
We will further investigate the role(s) played by MYC, MITF, HIF and USF exchange at common targets (which we identified through our ChIP-seq analysis) in gene activation and the effect on the (re)activation potential of these genes when DNA-binding by one or more of these factors are abolished, as well as when the promoter is monopolised by one of these factors through overexpression using cell lines expressing one of the bHLH-TFs under a tet-inducible promoter. In the long run, we aim to understand the potential differences in the role(s) of each bHLH-factors co-occupying E-box elements.

Keywords: MYC
bHLH-LZ
bHLH
USF2
USF1
HIF-1b
Transcription
HIF-2a
HIF-1a
MITF
Advisor: Goding, C
The dragon and the lamb: Christianity and political engagement in China

This thesis examines political engagement amongst young urban Chinese Protestants. Based on 100 interviews in Beijing and Shenzhen, 50 with Protestants, and 50 with non-Protestants, it focuses on three areas: national narratives (what individuals think about China, its current situation and its future direction), political opinions, and social and political activity.
I firstly argue that Protestants generally adhere to a relatively ‘critical’ national narrative, one that is more divergent from the Party-state’s nationalist discourse than that of their demographic peers. I then argue that in causal terms, it is primarily individuals who hold these critical values who are most drawn to Christianity, rather than developing the values as a result of their faith.
Secondly, Protestants do not just hold more negative opinions of China's political regime, but that the criteria by which they judge it are different. In contrast to their demographic peers, Protestants do not base their judgements of the regime on its performance at delivering on everyday political issues.
Thirdly, Protestantism catalyses the development of a sense of agency in its adherents: a sense of moral responsibility towards China and a desire to bring change through transformative activism. However, factors in China's cultural, historical, social and political context serve to steer Protestants' activism away from engagement with secular society and inward towards the church community.
I conclude by arguing that Protestantism poses two challenges to China's Party-state: Firstly, it is symptomatic of an underlying sense of social and political malaise, of scepticism towards the primacy of economic enrichment and towards the Party-state’s attempt to legitimise its rule based upon this. Secondly, Protestantism catalyses the emergence of a critical, morally agentic individualism that anchors its worldview in a discourse outside the control of the Party-state. Adapting to these social shifts presents a major future challenge for the CCP.

Keywords: China
Nationalism
Public opinion
Politics
Political engagement
Christianity
Protestantism
Advisor: Shue, V
Whitefield, S