VictorJuiz/thesis huggingface dataset:
'Misery in the moorlands': lived bodies in the Landes de Gascogne, 1870-1914

This thesis explores the embodied experiences of the rural population in nineteenth-century France. The prevailing historiography has treated rural bodily culture as a cultural survival swept away by ‘modernisation’ in the nineteenth century. By turning to the lives and words of rural labourers and artisans from the Landes de Gascogne, the thesis questions this account, instead showing ways that popular cultures of the body were flexible traditions, adapted by individuals to meet new needs. It does so through a close focus on the stories, songs, and other oral traditions collected by Félix Arnaudin (1844-1921) in the Grande-Lande between around 1870 and 1914. The thesis focuses on the lives of a few of Arnaudin’s 759 folklore informants, showing both how their bodily experiences were changing during this period, and how songs and stories were creative interventions, designed to shape bodily possibilities from below.
The thesis draws attention to the surprising shape of rural experiences of the body, which focused on body parts such as the legs and skin for reasons specific to everyday life, while largely ignoring issues that historians might have assumed would be important, such as religion. It argues that the ordinary men and women who performed stories and sang songs were active agents in constructing their own bodies in response to material conditions of physical illness and disability, as well as a changing environment, changing class relations, or changing sexual norms in the Grande-Lande. The thesis presents an emotional and experiential view of rural bodies with a sensitivity to the different experiences of men and women, young and old, poorer and richer, but emphasizes that the body must be seen in the round, as a unifying concern that links together issues of social class, environmental change, sexual relations, work, disability, and religion.

Keywords: modernisation
gender
history of the body
fairy tales
folklore
environmental history
folk songs
werewolves
Advisor: Hopkin, D
Adverbs in conceptual semantics

The thesis discusses and evaluates semantic representations of predicate-oriented modification (specifically by manner adverbs) and participant-oriented evaluative modification (by so-called “subject-oriented” adverbs). Analyses are proposed within the framework of Conceptual Semantics.

Keywords: predicate-oriented modification (by manner adverbs)
participant-oriented evaluative modification
conceptual semantics
adverbs
formal semantics
Advisor: Dalrymple, M
Accountability interactions: mutliple accountabilities in the Murray-Darling basin plan

This thesis investigates whether different public accountability forums interact with one another when they oversee the same decision maker. It contributes to the larger study of how decision makers are held to account in constitutional democracies where the simultaneous operation of multiple accountability relationships has become routine. Looking beyond the dominant assumption that multiple forums autonomously assess a decision maker's accountability against different and diverging standards, I aim to understand whether forums can influence the standards against which other forums evaluate the same decision maker.
I draw on political and normative understandings of public accountability to answer one central question: do different public accountability forums interact with one another in a way that influences the scope of what a decision maker is obliged to account for and the normative standards against which that account is evaluated? Answering this research question involves examining the mechanisms by which interactions might occur and the motivations of actors to interact.
I begin by critically reviewing the literature on multiple accountabilities, arguing that existing approaches can only partially explain how public accountability is constructed in multiple accountability regimes. I argue the focus on typologies of accountability emphasise the attributes of individual forums and overlook the broader dynamics of the accountability regime. I then develop an analytical framework to examine how the interactions between different forums, and other actors, might reshape the accountability dialogue.
This framework is used to analyse the case of the Murray-Darling Basin Plan in Australia (2008-2012). By presenting a contextSrich analysis of interactions between forums, and other actors, I find that multiple forums act in concert with one another and other actors to contest and then reshape the standards against which the two decision makers are evaluated. The thesis concludes by discussing the implications of recognising accountability interactions for understanding multiple accountability regimes.

Keywords: Public accountability
Accountability politics
Multiple accountability
Water regulation
Multiple accountabilities
Accountability
Advisor: Lange, B
Intertextuality, exegesis, and composition in polytextual motets around 1500

Over 450 motets survive from the fifteenth and sixteenth centuries which were composed with multiple simultaneously sounding texts. The size of this repertory has been underestimated and its importance under-acknowledged. Narratives of the genre overemphasize early fifteenth-century (and earlier) polytextuality due to its association with arcane rhythmic structuring techniques while stressing a new musical-textual ideal later in the century. This thesis is the first attempt to address the repertory of polytextual motets from the late fifteenth and early sixteenth centuries as a whole. It resituates polytextuality as a central aspect of the genre even after the supposed rise of musical humanism. It suggests a new partitioning of the repertory based on different relationships of texts and cantus firmi. It proposes that the function of cantus firmi shifts during this period toward acting in dialogue with the text(s) of the other voices, even though this dialogic aspect fades away by the mid-sixteenth century. It engages in case studies on small groups of motets, in which the notation, composition, and texts of motets are analyzed, especially concerning cantus firmi as elements of musical structure and as bearers of liturgical, biblical, devotional, and other associations. While scholars have undertaken numerous analyses of individual motets, less common are case studies which ask both why certain texts and cantus firmi were combined and how they were integrated into the musical structure. The appendix includes a catalogue of the repertoire of polytextual motets and chansons with Latin cantus firmi over this period, with indexes by cantus firmus and composer. Also included are transcriptions of seven polytextual compositions without published editions. My research demonstrates the importance of polytextuality within the genre, the sophistication of the compositions using it, and its ability to provide commentary on a number of theological, devotional, political, and aesthetic issues.

Keywords: Polytextuality
Motets
Advisor: Bent, M
Paul's 'new moment': the reception of Paul in Alain Badiou, Terry Eagleton, Slavoj Zizek

This thesis traces the ‘New Moment’ in Pauline reception in the writings of Alain Badiou, Terry Eagleton and Slavoj Žižek. It explores how the Pauline epistles are read and feature in their thought. An answer to the question, 'why Paul?' prompts reflection on what it is to read and understand the Apostle.
An introduction sets out the writers of this ‘New Moment’ [Jacob Taubes, Giorgio Agamben, Stanislas Breton, as well as Badiou, Eagleton and Žižek] before isolating the figures of this study. The reception of this ‘moment’ by mainstream New Testament studies is considered, and with it the charge of ‘appropriation’. The concept of ‘appropriation’ is explored, and a definition arrived at, for the purpose of evaluating the readings we will go on to discover.
As part of this notion of ‘appropriation’, the turn to Gadamer in recent New Testament study is surveyed. We suggest another potential hermeneutical approach that derives from Gadamer is possible. Thus, the object of this study is both an instance of, and means by which to critique the understanding of, New Testament Wirkungsgeschichte.
Each of our thinkers is then considered in turn. The outline for each chapter is the same. A brief introduction to the figure with bibliographical background salient to his Pauline reading precedes some textual examples indicative of that reading. We then move to analyse the manner of that reading and certain conceptual problems which are revealed in the course of the engagement with Paul.
The conclusion analyses the approaches, and reasons for turning, to Paul on the part of these thinkers. Salient differences between each thinker's reading are noted and the charge of appropriation is evaluated afresh. The implications of such readings for conventional biblical criticism are considered, and the success of an approach which explores a Gadamerean-inspired interest in reception in the manner adopted by this thesis is judged.

Keywords: Interpretation
Paul
Ricoeur
Gadamer
Marxist
Appropriation
Badiou
Reception
Eagleton
Continental Philosophy
Zizek
Hermeneutics
Advisor: Rowland, C
Ward, G
Structural, electronic and kinetics on organometallic intercalates of metal dichalcogenides

Large single crystals of the metal dichalcogenide hosts ZrS2 and 811X2 (X = S, Se) have been successfully intercalated with a variety of organometallic guests {C0(η-C5H5)2, CO(η-C5H4CH3)2, Mo(η-C6H6)2, Mo(η-C7H7)(η-C5H5), W(η-C7H7)(η-C5H5), Ti(η-C8H8)(η-C5H5)}. The structural and electronic properties of these materials have been studied, as well as the intercalation kinetics of these organometallic species into the tin dichalcogenides.
X-ray and neutron diffraction experiments have been used to obtain 001 reflections in order to obtain a one-dimensional profile of electron and neutron scattering in these disordered layered materials (Chapter Two). Refinement of the data shows that for all the organometallic guests, the majority of the intercalant adopts an orientation in which the principal molecular axis lies parallel to the layer planes of the host. These findings are confirmed by 2H NMR spectroscopy on single crystals of deuterated cobaltocene intercalates of ZrS2 and SnSe2, where it has been shown that rapid C5, but not C2, rotation of the metallocene occurs in the interlamellar van der Waals space.
To study the electronic properties of these intercalates, electrical resistivity and magnetic susceptibility measurements have been performed (Chapter Three). An apparatus has been built to measure the resistivity of these crystal intercalates down to 4.2K. The resistivity measurements show that intercalation of various organometallic complexes confers metallic properties upon ZrS2 while SnS2{Co(η-C5H5)2} 0.3 becomes a superconductor with a Tc of 8.3K. The magnetic susceptbility measurements confirm the presence of guest-host charge transfer. Estimates of its extent, as well as the magnitude of the Pauli susceptibility in these intercalates, have been attempted.
Studies on the rate and mechanism for the intercalation of cobaltocene into the disulfides and diselenides of tin have been performed (Chapter Four). An apparatus has been designed and constructed for in situ diffraction using synchrotron X-rays in order to monitor the progress of these rapid intercalation reactions. The results indicate that the rate of intercalation of cobaltocene into the tin dichalcogenides is very much dependent on the solvent used, being significantly faster in dimethoxyethane than in toluene. Analyses of the kinetic rate expressions for the tin dichalcogenide intercalation in dimethoxyethane suggests that diffusion of cobaltocene molecules into the interlamellar space constitutes the rate limiting step. The choice of solvent also dramatically affects the mechanism of the intercalation. When a solution of cobaltocene in dimethoxyethane is used, the host transforms directly to the final product but in toluene, staged intermediates are observed during the intercalation process. The apparatus and techniques that have been developed for the in situ kinetics experiments are general and permit dynamic structural transformations in air- and moisture-sensitive suspensions of solids to be effectively studied.

Advisor: O'Hare, D
Identification and functional analysis of single nucleotide polymorphisms that affect human cancer

Aims: The p53 regulatory network is crucial in directing the suppression of cancer formation and mediating the response to commonly used cancer therapies. Functional genetic variants in the genes comprising this network could help identify individuals at greater risk for cancer and patients with poorer responses to therapies, but few such variants have been identified as yet. Methods: We first develop and apply three different screens that utilize known characteristics of functional single nucleotide polymorphisms (SNPs) in the p53 network to search for variants that associate with allelic differences in (i) recent natural selection, (ii) chemosensitivity profiles, and (iii) the gender- and age- dependent incidence of soft-tissue sarcoma. Secondly, we study and explore the functional mechanisms associated with the identified variants. Results: We identify SNPs in the PPP2R5E, CD44, YWHAQ and ESR1 genes that associate with allelic differences in the age of tumour diagnosis (up to 32.5 years, p=0.031), cancer risk (up to 8.1 odds ratio, p=0.004) and overall survival (up to 2.85 relative risk, p=0.011) in sarcomas, ovarian and pancreatic cancers, and exhibit allelic differences in the cellular responses to cytotoxic chemotherapeutic agents (up to 5.4-fold, p=5.6x10-47). Lastly, we identify candidate causal SNPs in those genes and describe the regulatory mechanisms by which they might affect human cancer. Conclusions: Together, our work suggests that the inherited genetics of the p53 pathway have a great potential to further define populations in their abilities to react to stress, suppress tumor formation and respond to therapies.

Keywords: p53 pathway
single nucleotide polymorphisms
snp
Advisor: Bond, G
Specters of poverty and sources of hope in the novels of Amitav Ghosh and Rohinton Mistry

This thesis attempts to reformulate the concept of hope represented in, and inflected by, the Indian English novel. This comparative literary study focuses primarily on Amitav Ghosh and Rohinton Mistry, whose novels offer myriad examples and resultant effects of a reflexive hope. I argue in light of their work to refigure hope in its varied and multiple articulations: positive and negative, for-life and for-death, dependency, waiting, nostalgia, narcissism. All of these, I suggest, manifest in a nominal-messianic hope that formulates a powerful critique of global capital most advantageously constellated in these Indian English novels. I arrive at this from the early writings of Jawaharlal Nehru and his unshakable belief in socialist progress that informs the productive tension within hope that inform the readings of Ghosh’s and Mistry’s novels. Concomitant to this thesis on hope is the recalibration of definitions of poverty to the principles of capabilities that allow for the simultaneous discussion of how the state can shape social opportunities for its citizens. This, I argue, is necessary for the flourishing of more nuanced understanding of hope. Moving away from purely quantitative measurements of poverty to more qualitative capabilities pushes the novel to the foreground of these arguments. Just as Nehru explores his own formulations of hope and hopefulness through the poetry of Matthew Arnold, the Indian English novel, here, is best able to enunciate a reflexive hope that is central to the notion of capabilities. This is why poverty studies in India needs the Indian English novel.

Keywords: postcolonial
Rohinton Mistry
Amitav Ghosh
Jawaharlal Nehru
Matthew Arnold
poverty
hope
Advisor: Boehmer, E
Distinguishing bipolar disorder and borderline personality disorder: an exploration of clinical and neuroscience informed approaches

Bipolar disorder and borderline personality disorder are common psychiatric diagnoses. One is a mood disorder with a strong genetic basis while the other is a disorder of personality commonly related to abusive experiences in childhood. Despite contrasting aetiologies they can be difficult to differentiate because of overlapping clinical presentations and symptoms. Diagnostic accuracy is important because of their polarised treatment approaches: long term treatment with mood stabilizers for bipolar disorder and psychotherapy for borderline personality disorder.
A qualitative study of psychiatrists revealed comprehensive knowledge of the diagnostic criteria however, many expressed the view that diagnostic criteria did not assist diagnostic differentiation. These findings were validated in a large electronic survey of UK psychiatrists. A detailed study of actual diagnostic processes revealed that this scepticism appeared to influence actual practice. Clinicians largely ignored diagnostic criteria but continued to give diagnoses.
Age and IQ matched women with bipolar disorder, borderline personality disorder and a healthy control group were compared in a series of cognitive tasks. Borderline personality disorder was associated with a failure to establish and maintain reciprocal cooperation in a game theoretic measure of social exchange. This behavioural change was not seen in euthymic bipolar disorder. Borderline personality disorder was also associated with an insensitivity to reward and losses in a risky decision-making task. Using a simple two-choice reaction task post error slowing was significantly amplified in the borderline group despite overall reaction times and error rates being similar in all three groups.
Clinical diagnostic practice as revealed in this study is not adequate to reliably differentiate between bipolar disorder and borderline personality disorder. Laboratory measures of social exchange, decision making and post-error slowing highlight fundamental difficulties in borderline personality disorder not seen in euthymic bipolar disorder. These findings support the differentiation of bipolar disorder from borderline personality disorder and offer translational models for developing and evaluating new treatments for borderline personality disorder.

Keywords: bipolar disorder
borderline personality disorder
Advisor: Goodwin, G
Robert, R
Exploring small bite-angle PNP and PCP ligands for the rhodium-catalysed intermolecular hydroacylation of b-s-substituted aldehydes with alkenes and alkynes

This thesis discusses the intermolecular hydroacylation reaction using cationic rhodium bis- phosphine complexes as catalysts. A series of small bite-angle rhodium bis-phosphine complexes have been prepared and characterised. The reactivity of these complexes has been investigated in order to gather information about the effect of subtle changes in the ligand design and they are compared to the previously reported catalysts.
Chapter 2 presents the challenges involved in the synthesis of small bite-angle isopropyl and cyclohexyl PNP and PCP bis-phosphine ligand containing rhodium complexes. These complexes have been fully characterised and screened in intermolecular hydroacylation reaction using 2- (methylthio)benzaldehyde (E) and 1-octene or 1-octyne as substrates. The formed complexes were shown to be very efficient and regioselective alkyne hydroacylation catalysts. The mechanism of the hydroacylation reaction was investigated using the isopropyl PNP complex [Rh(iPrPNMePiPr2)(C6H5F)][BArF4] (11b).
Chapter 3 concentrates on developing new rhodium bis-phosphine complexes that involve a ligand incorporating the small bite-angle motif with the one of hemilability. The PNP complex [Rh((2-OMe-C6H4)2PNMeP(2-OMe-C6H4)2)(C6H5F)][BArF4] (41) was synthesised and analytically characterised. 41 was shown to be an active alkyne hydroacylation catalyst with more stability towards the catalyst deactivation pathway, reductive decarbonylation, compared to the previously investigated 11b. Additionally mechanistic studies using 41 were carried out.
The final chapter moves on to study the C-S activation ability of small bite-angle rhodium bis- phosphine complexes to remove the sulfur tether from the hydroacylation products at the end of the hydroacylation reaction. A screening is conducted to compare the reactivity of different small bite-angle ligands. Additionally, a detailed investigation is carried out to see the effect the C-S activation has on the hydroacylation reaction.

Keywords: homogeneous catalysis
small bite-angle
hydroacylation
phosphine
rhodium
Advisor: Weller, A
Delta-like 4 - Notch signalling in angiogenesis and tumour biology

Notch signalling plays a key role in physiological development and tumourigenesis. The recent discovery and characterisation of Notch ligand Delta-like 4 (D114), which is predominantly expressed in endothelial cells, have underscored the role of Notch signalling in angiogenesis. This thesis investigates the regulation and function of D114-Notch signalling in angiogenesis and tumourigenesis.
First, the D114-Notch pathway interacted with the cellular hypoxia-sensing pathway. In human umbilical vein endothelial cells (HUVECs), D114 overexpression repressed hypoxic induction, and the repression was mediated by Notch target gene Hey2. In the breast cancer cell line MCF7, hypoxia induced Notch target gene Hey1 and ligand Jagged2 via hypoxia inducible factor 1. The hypoxic induction of Hey1 was also dependent on Notch signalling.
Second, D114 expression in HUVECs was up-regulated by several pathways. Notch signalling, activated by receptor overexpression, ligand stimulation or cell-cell contact, induced D114 expression. Treatment with vascular endothelial growth factor (VEGF) or hypoxia also induced D114 expression via Notch signalling. In addition, VEGF promoted Notch signalling and D114 expression in tumours.
Third, D114 expression in HUVECs was up-regulated by co-culturing with cancer cells. B16 mouse melanoma cells and human breast cancer cell lines induced D114 expression in HUVECs via Notch signalling. B16 cells also induced D114 expression via soluble factors independent of Notch signalling.
Finally, D114-Notch signalling regulated tumour growth in vivo. D114 overexpression in cancer cell lines activated Notch signalling in the stroma of xenograft tumours, and promoted the growth of human U87 (glioblastoma) and PC3 (prostate cancer) xenografts. In addition, D114-overexpressing U87 tumours were resistant to anti- VEGF treatment during later stages; however, they did respond to anti-Notch treatment.
Altogether, the D114-Notch pathway is tightly regulated and plays an important role in physiological and tumour angiogenesis. Inhibiting this pathway may be a viable therapy for cancers resistant to VEGF inhibition.

Advisor: Harris, A