VictorJuiz/thesis huggingface dataset:
John Bellenden's Chronicles of Scotland

John Bellenden's Chronicles of Scotland (1531-r. 1537) is a humanist Scots translation of Hector Boece's Scotorum Historia (1527). As the first full-scale printed national history in the vernacular, the Chronicles assumed a pivotal role in sixteenth-century Scottish literary culture. Despite its contemporary importance,however, relatively little critical attention has been paid to Bellenden's work itself, primarily due to the misconception that it is a neutral translation of the Scotorum Historia. However, as Bellenden successively revised his text in several stages with stylistical, ideological and material alterations, the Chronicles needs to be evaluated as an individual literary work. The Chronicles
reveals much about translation practice, cultural attitudes and book history in early modern Scotland.
This thesis situates John Bellenden as a leading vernacular humanist whose concern to heighten the quality of vernacular Scots gave major impetus to the vernacular tradition in Scottish historiography. Chapter 1 shows how Bellenden's overall translation policy is indebted to humanist literary precepts and shows how its embodiment evolves through the course of his revision work. The following three chapters, which deal with Books 1, 12 and 16 of the Chronicles respectively, demonstrate the changing nature of Bellenden's translation and revision practice. A comparative analysis of the first manuscript version, three intermediary manuscript versions and the final printed version exhibits how Bellenden's attitude towards the Chronicles is affected by his ultimate respect for humanistic quality, and his consideration of his patrons and his audience. Chapter 5 examines the contemporary reception of the Chronicles. The conclusion seeks to reevaluate the congruity of the Chronicles with the contemporary cultural milieu and its influence on subsequent historiography and literature within and outwith early modern Scotland.

Advisor: Mapstone, S
An experimental study of the dynamic response of notched bars

A survey is made of analytic, experimental and numerical techniques in the field of the dynamic initiation, and early propagation, of cracks. As no closed form analytic solutions exist for finite geometries, even in the elastic case, numerical and experimental techniques have to be developed. In instrumented impact tests plasticity often occurs.
The specific problem of the Instrumented Charpy Test is discussed in detail by virtue of its technological significance and the extensive literature available for the test. Although a standard for the test has been proposed there are still outstanding questions to be answered, for which the techniques described above can be used.
The problem of the dynamic calibration of various notched geometries is addressed in the original work of the thesis. The Charpy, Izod, Slender Cantilever and Double Notched Bar geometries are studied using dynamic photoelasticity and 8000 fps photography. It is shown that the response of the DNB is more straightforward than the Charpy geometry.
Further photoelastic study of the latter two geometries, using epoxy model material and 106 fps photography, gives a quantitative measure of the growth of stress intensity factor at the notch tips and hence a dynamic calibration is deduced. An explicit finite difference code is used to supplement photoelastic data.
Having achieved progress in the derivation of the dynamic calibration of the two selected geometries, corresponding instrumented impact tests are then undertaken. The Hopkinson Pressure Bar method of loading is used.
It is concluded that the proposed standard for the Instrumented Charpy Test is valid within limits but that there is a requirement for a dynamic calibration. Such a calibration is complex in the case of the Charpy geometry whereas a simpler geometry, viz. DNB, could prove to be more amenable to analysis and hence be more practical from the technological point of view.

Advisor: Ruiz, C
Ruiz, I
Assessment and treatment of malignant pleural effusions: visual analogue scale, ultrasound and drainage

This thesis consists of 3 studies:
1. Determination of the minimal important difference (MID) of the visual analogue scale for dyspnoea (VASD):
Determining the MID of the VASD is essential to interpret the results of trials in patients with malignant pleural effusions (MPEs). Patients undergoing a pleural procedure assessed the change in their VASD and the degree of change in their symptoms on a Likert scale. The mean VASD in patients experiencing a ‘small but just worthwhile’ decrease in their symptoms is the MID for the VASD and was found to be 22mm (95% CI 16 - 27mm).
2. Development of a thoracic ultrasound septation score (TUSS):
A TUSS is important for objectively assessing the degree of septation within a pleural effusion. An iterative process was used to demonstrate that degree of septation predicts clinical outcome, to identify candidate factors for inclusion in a TUSS and to determine which factors predicted the degree of septation. The final TUSS consisted of an assessment of the degree of homogeneity of septation distribution and number of septations at the most septated area.
3. Effect of an indwelling pleural catheter (IPC) versus standard care for relieving dyspnoea in patients with MPEs: the TIME2 randomised controlled trial (RCT).
The objective of this unblinded RCT was to determine whether IPCs are more effective than chest drains and talc pleurodesis at relieving dyspnoea in patients with MPEs. 106 patients were randomised to either IPC or standard care in a 1:1 ratio. The primary outcome was daily VASD over 42 days post intervention. Dyspnoea improved in both groups with no significant difference in mean dyspnoea in the first 42 days (mean score: IPC 25mm (95% CI 19 – 30), standard care 24mm (95% CI 19 – 29).

Keywords: dyspnoea
visual analogue scale
pleural effusion
ultrasound
Advisor: Stradling, J
Maskell, N
The vocal and homing behaviour of the Manx shearwater Puffinus puffinus with additional studies on other Procellariiformes

The marine birds comprising the order Procellariiformes are an ancient and diverse assemblage. A large proportion are both nocturnal and burrow-nesting at their breeding colonies, where in sharp contrast to their behaviour at sea, they are highly vociferous. Virtually nothing is known regarding the adaptive features of this process. Various aspects of vocal behaviour have therefore been investigated from 1981 to 1983 for seven species at breeding stations in both the boreal and sub-tropical North Atlantic Ocean. In addition, the problem of how these birds return to their correct burrows at night has been considered.
A detailed study was conducted on the Manx Shearwater Puffinus puffinus. Various approaches showed that immatures contribute most to the calling heard. Males establish and defend burrows, but both sexes partake in aerial calling. Calling at ground level serves both sexual and territorial functions, whereas aerial calling is probably mainly concerned with sexual advertisement. Some males are more silent in flight than others. These probably represent birds as yet without burrows, perhaps the youngest age classes. Flighting activity probably expedites the acquisition of burrows and mates in these birds which are awkward on land, and aerial calling probably improves signalling efficiency in attracting mates.
Six other species (Bulweria bulwerii, Calonectris diomedea, Puffinus assimilis, Hydrobates pelagicus, Oceanodroma castro, Pelagodroma marina) were studied. As with Puffinus puffinus, sexual differences in voice exist for all except Bulweria and Pelagodroma, which also lack aerial calls. Thus a functional link exists between flight calls and their sexual divergence. Selection probably favours such divergence in species where males leave burrows to display in flight; the sexual identity of those species whose males do not is unambiguous as they remain in burrows and call.
The calls of Puffinus puffinus and Hydrobates pelagicus were compared at local and regional levels. Divergence exists between but not within islands. Vocal drift in Puffinus puffinus is also apparent after several years. The calls of the nocturnal Procellariiformes are reviewed and discussed in relation to their systematics. The potential use of calls in petrel systematics is also evaluated and shown to be useful.
Observations on Puffinus puffinus showed that olfactory and auditory cues are not used for burrow homing. Experiments also confirmed this, and point to sufficient visual development in this species, although other senses may be emphasised in different ecological situations.

Advisor: Perrins, C
Broadband optical quantum memory

This thesis is about the experimental implementation of a high-speed and robust quantum memory for light. A novel far off-resonant Raman approach to ensemble-based quantum memories in a room-temperature environment is developed and demonstrated. Storage and retrieval of sub-nanosecond, weak coherent light pulses at the single-photon-level with total efficiencies exceeding 30% and storage times of up to 4 μs are achieved. The coherence of the memory is shown by directly interfering a copy of the incident signal with the retrieved signal from the memory. The unconditional noise floor of the memory is found to be low enough to operate the memory in the quantum regime at room temperature. Multiple readout of a single stored excitation is demonstrated, suggesting that 100% readout is possible in different temporal modes. Furthermore, first results regarding the storage and retrieval of polarisation encoded qubits are obtained. This and the memory’s ability to operate in the quantum regime at room temperature with a low unconditional noise floor illustrate its potential usefulness for real world applications.

Keywords: quantum information
quantum communication
Advisor: Walmsley, I
Optical wireless communications for micro-machines

The main objective of this thesis is to develop a communication system that can minimize the micro-machine size and power consumption and maximize the link range and the number of micro-machines that can communicate simultaneously with the base station.
Several possible communication systems are compared, including RF communications and active and passive free space optical communications. A directed, half duplex LOS link using a Ferroelectric liquid crystal (FLC) or multiple quantum well (MQW) modulating retroreflector-base passive uplink is then examined in more detail.
Two potential geometries are described. In a broad-beam system, light from a source is broadcast to all micro-machines within the field of view (FOV). However, simulations show that the performance is unacceptable for most applications. In a narrow-beam system, light is holographically steered to active micro-machines within the same FOV. Therefore, the link budget has been improved. For a BER not exceeding 10-9, the 850 nm LC narrowbeam system can support maximum range of 146 m at a data rate of 10kbits/s, and the 1525 nm MQW narrowbeam system can support a maximum range of 34 m at a data rate of 10Mbits/s, when the transmitted power in the diffracted beam of the positive first order is 0.5 mW.
Experiments have been carried out to verify the model. These were initially carried out with MQW Modulating RetroReflector (MRR). Results were then be used to modify the characteristics of these components in the model. Available components and discrete electronics have been used to set up a simple retro-reflecting link. Experiments have been performed at a limited data rate of 1 kbits/s over a limited range of 1m due to creating a uniform interrogation beam spot, and the active area of the receiver of 1 mm diameter. An algorithm to find the MQW MRR within the FOV is designed and tested.

Keywords: Optical wireless communications
Smart Dust
Advisor: O'Brien, D
Dynamic spectrum sharing for future wireless communications

The spectrum has become one of the most important and scarce resources for future wireless communications. However, the current static spectrum policy cannot meet the increasing demands for spectrum access. To improve spectrum efficiency, dynamic spectrum access (DSA) attempts to allocate the spectrum to users in an intelligent manner. Cognitive radio (CR) is an enabling technology for DSA, and can maximize spectrum utilization by introducing unlicensed or secondary users (SUs) to the primary system. The key component of DSA is dynamic spectrum sharing (DSS), which is responsible for providing efficient and fair spectrum allocation or scheduling solutions among licensed or primary users (PUs) and SUs. This thesis focuses on the design of efficient DSS schemes for the future wireless communication networks.
Firstly, based on the coordinated DSS model, this thesis proposes a heterogeneous-prioritized spectrum sharing policy for coordinated dynamic spectrum access networks. Secondly, based on the uncoordinated DSS model, a novel partial spectrum sharing strategy and the cross-layer optimization method have been proposed to achieve efficient spectrum sharing between two licensed networks. Then, a hybrid strategy which combines the overlay and underlay schemes is proposed under uncoordinated DSS model. The proposed analytical methods can provide efficient and accurate modeling to predict the behaviors of the PUs and SUs in DSS systems. This thesis presents the performance prediction of the proposed novel DSS schemes that achieve efficient spectrum sharing for coordinated and uncoordinated future wireless networks.

Keywords: wireless communications
performance analysis
dynamic spectrum access
Markov chain
Advisor: Edwards, D
The role of catechol-O-methyltransferase (COMT) in hippocampal function

Catechol-O-methyltransferase (COMT) metabolises catechol-containing compounds, including dopamine. The aim of this thesis was to investigate whether COMT is involved in hippocampal function. This thesis also explored the role of functional polymorphisms within the COMT gene in the pathogenesis of schizophrenia and schizophrenia-related phenotypes.
First, as part of a study investigating the role of COMT in schizophrenia, human hippocampal COMT mRNA levels were shown to be neither altered in schizophrenia or bipolar disease, nor affected by COMT genotype. Hence, functional COMT polymorphisms do not appear to operate by altering gross COMT mRNA expression. Importantly, this study showed that COMT is expressed in the human hippocampus.
Second, the role of COMT in hippocampal neurochemistry was explored by studying the effect of pharmacological COMT inhibition on catecholamines and metabolites in rat hippocampal homogenates, and extracellularly, using microdialysis. Both demonstrated that COMT modulates hippocampal dopamine metabolism. Thus, hippocampal COMT is of functional significance with respect to dopamine.
Third, the effect of COMT inhibition on hippocampus-dependent behaviour was investigated. The results suggested a memory-enhancing effect of pharmacological COMT inhibition on hippocampus-dependent associative and non-associative forms of short-term memory in rats. In contrast, acute COMT inhibition appeared to have no effect on behavioural correlates of ventral hippocampal function i.e. anxiety-like behaviour.
In summary, the expression of COMT mRNA in the human hippocampus, as well as the effect of COMT inhibition on rat hippocampal neurochemistry and hippocampus-dependent behaviour provide evidence for a functional role of COMT in the hippocampus. Moreover, changes in COMT activity alter hippocampal dopamine metabolism, which could be a potential mechanism for the role of COMT in hippocampus-dependent short-term memory.

Keywords: hippocampus
dopamine
COMT
noradrenaline
schizophrenia
Catechol-O-methyltransferase
Advisor: Harrison, P
Tunbridge, E
The dream in classical Greece

This thesis aims to address the Greek attitude to their dream experience in the classical period, as it was conceived in theories and engaged with in dream practices. The emphasis is on the relationship between these elements and the wider cultural frames which surrounded them, in order both to illustrate the manner in which culture influences the conception of dreams, and also to use dreams themselves as a mirror to reflect parts of Greek culture. As a study it has been heavily shaped by the approaches to dreams developed by anthropologists, outlined in Chapter 2, who have emphasised the importance of studying dreams intra-culturally.
In Chapter 3 I analyse the language that the Greeks used to express their dreaming experience, drawing from it the important way in which language was both determined by, and determined, the Greeks' understanding of the phenomenon. This forms a base for engaging with dream theories in Chapter 4, both the implicit allusions in literature and explicit explanations proposed by philosophers and medical writers. I then explore the theories at work within Greek culture via dreams as we see them active in the lived religion of the polis: I examine in Chapter 5 the dedications set up by individuals on account of spontaneous dreams, and in Chapter 6 the practice of incubation. I then turn to examine specific relationships: in Chapter 7, the association of dreams with status, i.e. the possibility that powerful people would have equally powerful dreams; in Chapter 8, dreams and gender, assessing the possibility that women considered their dreams to be more important than their male counterparts. In Chapter 9, I position dreams within the context of the other divinatory practices of the period, which allows us to see the unique ways in which dream practices functioned in comparison to the other divinatory forms.

Advisor: Parker, R
Studying protein-DNA interactions in vitro and in vivo using single-molecule photoswitching

Protein-DNA interactions govern the fundamental cellular processes of DNA replication, transcription, repair, and chromosome organisation. Despite their importance, the detailed molecular mechanisms of protein-DNA interactions and their organisation in the cell remain elusive. The complexity of molecular biology demands new experimental concepts that resolve the structural and functional diversity of biomolecules.
In this thesis, I describe fluorescence methods that give a direct view on protein-DNA interactions at the single-molecule level. These methods employ photoswitching to control the number of active fluorophores in the sample. Forster Resonance Energy Transfer (FRET) measures the distance between a donor and an acceptor fluorophore to report on biomolecular structure and dynamics in vitro. Because a single distance gives only limited structural information, I developed "switchable FRET" that employs photoswitching to sequentially probe multiple FRET pairs per molecule. Switchable FRET resolved two distances within static and dynamic DNA constructs and protein-DNA complexes. Towards application of switchable FRET, I investigated aspects of the nucleotide selection mechanism of DNA polymerase.
I further explored application of single-molecule imaging in the complex environment of the living cell. Photoswitching was used to resolve the precise localisations of individual fluorophores. I constructed a super-resolution fluorescence microscope to image fixed cellular structures and track the movement of individual fluorescent fusion proteins in live bacteria. I applied the method to directly visualise DNA repair processes by DNA polymerase I and ligase, generating a quantitative account of their repair rates, search times, copy numbers, and spatial distribution in the cell. I validated the approach by tracking diffusion of replisome components and their association with the replication fork. Finally, super-resolution microscopy showed dense clusters of SMC (Structural Maintenance of Chromosomes) protein complexes in vivo that have previously been hidden by the limited resolution of conventional microscopy.

Keywords: Fluorescence microscopy
Escherichia coli
Fluorescence Resonance Energy Transfer
DNA-Binding Proteins
Advisor: Kapanidis, A
Positive sum reciprocal engagement between China's grassroots NGOs and the local state

This thesis explores state-society relations in China by focusing on the interactions between grassroots NGOs and local government departments. It presents the notion of positive-sum reciprocal engagement as one form of relationship that can emerge between the state and social organizations. Such engagement can be characterized as a dynamic and interactive process implying proximity, communication, joint action, mutual influence, mutual benefit and mutual empowerment, resulting in added value for society.
Drawing on fieldwork carried out in six rural or semi-rural Chinese localities, including interviews and questionnaires with local government departments and indigenous grassroots NGOs, this study seeks to identify the conditions under which positive-sum reciprocal engagement is likely to emerge. It finds that the presence of reformist officials, the strengthening of NGO capacity in framing issues to open social spaces and to engage in effective action while communicating the results of such action are particularly important to establishment of reciprocal engagement. Significant structural or contextual factors include positive associational experience and openness in the locality.
This study also explores the extent to which grassroots NGOs are able to affect the formulation and implementation of policy at the local level, and finds policy influence to be one of the significant outcomes of positive-sum reciprocal engagement. One mechanism through which policy influence occurs is in the context of a mass-line model of communication, in which NGOs participate in discourses on social issues and act as channels for the conveyance of policy information and suggestions. Grassroots NGOs are also able to model innovations and contribute to policy formulation and reform in carrying out concrete programs, which is made possible by an environment characterized by policy flexibility and amenable to experimental points.

Keywords: local government
NGOs
China
development
Advisor: Vivienne, S
Equality and diversity

This thesis analyses the gender dimensions of work-life balance policies in the UK. It focuses on three related questions: firstly, to what extent are work-life balance policies framed by 'diversity'; secondly, how does this impact on the conceptualisation and implementation of work-life balance policies (in government and in organisations); and thirdly, what are the implications for gender equality?
Through analysing published research, the UK Government's work-life balance agenda and data generated from three selected case study organisations, the prominent dimensions of diversity that shape the conceptualisation and implementation of work-life balance policies are presented. This thesis argues that the concept of diversity - as defined by the feminist literature - offers the potential to progress gender equality through overcoming the same-difference dichotomy, and by recognising multiple aspects of identity. However, this theoretical potential is not necessarily reflected in practice. With the emphasis on the individual worker and choice, diversity has been primarily defined as 'managing diversity', and has a significant affect on how work-life balance policies have been applied in both government policy and organisational practice.
The UK Government states that work-life balance policies are meant to provide everyone with opportunities to balance work with other aspects of life. The current policy framework targets parents and in particular mothers, potentially limiting the choices that men and women have to 'work' and 'care'. Locating work-life balance policies within the context of 'managing diversity' supports and facilitates women's employment, but does not necessarily challenge fundamental gender disparities such as occupational segregation and gender pay gaps. Analysis of the UK Government's current agenda and organisational case studies show that despite progressive equality, diversity and worklife balance agendas, work-life balance policies are limited in challenging persistent structural gender inequalities.

Advisor: Bennett, F