VictorJuiz/thesis huggingface dataset:
Le feu source de régénération dans la poésie de Roland Giguère

La poésie de Roland Giguère est une quête de vivre mieux, d'aller vers un ailleurs où l'amour est tout. Cette quête commence dans L'Âge de la parole où il existe une forte dichotomie, entre le feu négatif et le feu positif, entre la lumière qui montre le passage hors du désespoir et le feu, mort qui garde le poète prisonnier. Le poète rêve que le feu parfait lui donnera, la liberté, mais une incertitude demeure et on ne sait pas si le désir du poke est accompli ou si ce n'est qu'un rêve. Dans 'La Main au feu', le poète passe à l'action, il avance, il évolue entre les feux. Il veut maintenant fuir le pays des feux morts. Le poète appelle le feu: "nouveau", "langue de feu", et "feu intérieur" pour suggérer que le feu n'existe pas seulement dans le domaine terrestre mais peut aussi mener vers la transcendance. L'aspect "éphémère" révèle cependant le fait que, le feu peut être aussi transitoire, tandis que la, présence des oiseaux et des bûchers expriment une nouvelle espérance. La contemplation de la quête, cependant, est toujours dans le domaine du rêve. Le poète réalise le but de sa quête dans ' Forêt vierge folle'. Il sait maintenant qu'il doit passer par le feu, pour s'envoler vers l'ailleurs qu'il désirait au début de sa quete vers la transcendance, la "re-vie".
The Chinese school enterprise, an organizational culture study

The purpose of this study is, in the Chinese social context, to document the nature of the Chinese school enterprise and to identify the relationships between the enterprise and its social environment and especially the changes in organizational culture. This study adopts the organizational culture theory of Edgar Schein as its framework in order to examine the organizational culture of the school/enterprise at three levels, those of artifacts, values and assumptions. Six schools were studied which covered different types of schools and various geography areas. Observations, documentation and semi-structured interviews were the major sources of data. A follow-up telephone interview was conducted two years after the data were first gathered in 1995. The Chinese school enterprise provides a success model which combines business functions with academic achievement within a school. The existence of the enterprise reflects a transition of Chinese society from a highly centralized administrative model to one which features a marketing economy system. Funding from the school enterprises has served to increase the principals' power in decision-making, helped schools to update teaching facilities and to improve teacher and staff welfare. The enterprise activities have effected changes in school cultures which have been observed in the environmental settings of the schools, the responsibilities of principals and the standards used to evaluate principals and managers. These changes further explore deeper changes in the underlying values and assumptions of the school and enterprise administration. Little change has occurred at the classroom level. Although there is ongoing world-wide movement toward public school involvement in business activities, very little research has been conducted in this field. This research makes a contribution toward the understanding of the relationships between the business and the academic function of schools and, in addition, provides school principals with an alternative administrative model whose implications extend to public school finance and policy-making in general. Further study is recommended into the area of possible conflict between educational function and business responsibility.
Endoglin is an accessory protein of multiple signalling receptor complexes of the TGF-ß superfamily, implications on the development of hereditary hemorrhagic telangiectasia type 1 (HHT1)

'Endoglin' (CD105) is the gene mutated in the autosomal dominant vascular disorder HHT1 and codes for a major integral membrane glycoprotein expressed on all vasculature. In endothelial cells, activated monocytes, and leukemic cells, endoglin associates with TGF-ß1, -ß3, and the heteromeric TGF-ß signalling receptor complex, consisting of type I and II ser/thr kinases. This thesis investigates the biochemical function of endoglin by determining the molecular mechanism underlying HHT1, and by studying the nature of endoglin interaction with TGF-ß receptors. Endoglin expression in members of confirmed HHT1 families was analyzed, and compared to normal. Both endothelial cells and activated monocytes were found to express about half levels of fully processed cell surface endoglin which represents expression from the normal allele. A search for mutant proteins reveals that proteins if detectable, are transiently expressed intracellularly, and not at the cell surface where endoglin functions. This thesis demonstrates haploinsufficiency is the predominant mechanism underlying the HHT1 phenotype, thus a critical level of endoglin is required in vasculature, and possibly other cells where it is expressed. Endoglin modulates some TGF-ß1 responses in certain cell types. However, I show HHT1 HUVEC do not exhibit altered proliferative responses to TGF-ß1. 'ALK1', the target gene for HHT2, codes for an orphan type I receptor that functions in BMP signalling pathways. Endoglin and ALK1 are likely involved in a common pathway suggesting endoglin could interact with other members of the TGF-ß superfamily. I tested this hypothesis and show endoglin interacts with TGF-ß1, -ß3, activin-A, BMP-2 and BMP-7, but cannot bind ligands without coexpression of the respective ligand binding kinase receptors. Endoglin specifically interacts with multiple heteromeric signalling complexes for these ligands, but does not disrupt their formation. My results suggest that endoglin does not act as a true receptor, and I define endoglin here as an accessory protein for the TGF-ß superfamily that could modulate the signalling capacity of the receptor complex. Endoglin function in endothelial, hematopoietic and other cell types, is thus highly dependent on the repertoire of TGF-ß family receptors the cells express.
Analysis of gene expression in cardiac development and disease

Large-scale partial sequencing of randomly selected cDNA clones to generate expressed sequence tags (ESTs) is an efficient means of discovering novel genes and characterizing transcription in different tissues. To characterize gene expression and its changes in cardiac development and disease, an EST project was initiated using adult and fetal human heart cDNA libraries. Generation of 3,874 ESTs from an adult heart library, representing the first catalogue of genes expressed in the cardiovascular system, revealed that approximately half of all transcripts represented genes of unknown function. Analysis of the remaining half of transcripts representing known genes demonstrated expression patterns consistent with physiologic function of the heart. Comparison of these patterns with those derived from 2,244 ESTs generated from fetal heart, and with patterns obtained from other tissues, found several differences in gene expression between fetal and adult heart suggestive of a rapidly growing, less differentiated phenotype in the fetal heart relative to the adult heart. Further acquisition of larger numbers of ESTs from nine cardiac cDNA libraries, coupled with development of new strategies for data analysis, allowed for detailed prediction of individual genes exhibiting differential expression in cardiac development and disease. These strategies were applied to analyze gene expression in hypertrophic failing heart, and to study the expression of cell cycle regulators in cardiac development and hypertrophy. In the former analysis, a total of 64 genes was predicted to be differentially expressed in cardiac hypertrophy. Supporting the validity of these predictions, RT-PCR analysis of 12 of these genes confirmed 11 to be differentially expressed. In the latter analysis, transcripts of cell cycle regulators were suggested to be differentially expressed between fetal and adult hearts. Subsequent ' in vitro' analyses confirmed down-regulation of S- and G2/M-phase regulators in adult heart relative to fetal heart, and also found re-induction of several S-phase (e.g., cyclin A, PCNA), but not G2/M-phase (e.g., cyclin B, cdc2), regulators in hypertrophy. These results extend, at a molecular level, current understanding of cardiovascular function, while suggesting several new avenues of investigation. Further, they demonstrate the power of EST-based expression analyses for exploring questions of cardiovascular biology and medicine.
A comparison of literacy and working skills of students in the co-operative education program with students working part-time

This study found that only about three in ten students practise a culture of reading in the senior high school years. Most students have ambivalent attitudes toward reading which signals a failure of schools to capture or cultivate students' reading interests. Weak readers do not read, and do not expect to be in school in five years' time, confirming the relationship between poor literacy and lack of pursuing education. Three in ten ESL students experience a prolonged period of weak English reading skills suggesting a need to study this issue more closely. Preparing students for the labour market with the Co-op design of a structured interface between school subjects and the workplace fosters positive learning and working attitudes; advances the pursuit of career and educational goals; and strengthens students' labour market readiness and employability skills. Working part-time benefits students, but to a lesser extent than that found for Co-op, although Co-op students working part-time surpassed both groups of students in acquiring generic skills and positive attitudes, suggesting that part-time work complements Co-operative Education. The benefits of Co-op point to the value of schools supporting all students in a structured program to facilitate the school-work transition. Such a program needs particularly to monitor students' working and Co-op hours and the type of work in the context of grades and career goals.
Constructing regional histories, time and transition in the southern Levant (5500-3500 BC)

For all archaeological research, chronological frameworks are the foundation on which any reconstruction or interpretation of historical process must rest. Both the resolution of a chronology and the research objectives of the archaeologist determine what questions can be asked or answered. Rarely, however, are chronological sequences definitive and they are never entirely objective, despite the increasing sophistication of method. Their construction is guided not only by contemporary research paradigms but also by a number of theoretical and methodological assumptions. Chronologies, like social, economic, political, or ideological reconstructions, are interpretations of the data, and their validation rests not so much on experiment or empirical testing as it does on their coherence when all sources are considered. The objectives of this study are two-fold. The first objective is to introduce alternative methods for the construction of chronological frameworks in order to determine the developmental sequence of Chalcolithic (5100-3500 BC) society in the Jordan Valley region of the southern Levant. In this regard, it addresses a number of issues relating to settlement and social change throughout the period and proposes several explanations based on the sequence of events. The second objective is to evaluate the theoretical and methodological understandings associated with the classification of chronological units. This study advocates the integration of all sources of chronological information for the purpose of composing regional histories. It introduces the Unitary Association Method of Relative Dating (UAM) as a means of constructing relative sequences and demonstrates the usefulness of Bayesian methods for improving the precision of radiocarbon dates using stratigraphic information as 'a priori' statements. In the final analysis, the agreement of both the relative and the radiocarbon sequence is considered.
Episodic memory for personally relevant information, evidence from aging, divided attention at retrieval and positron emission tomography

Three components of episodic memory are retrieval content, retrieval success, and retrieval experience. These components, as they relate to episodic memory for personally relevant information, were investigated in two behavioral experiments and in a positron emission tomography (PET) experiment; the PET study investigated the neural correlates of the three components with particular attention paid to changes in frontal activity. In each experiment retrieval content was investigated by comparing the retrieval of adjectives that were processed in one of four ways: in terms of the self, another person, social desirability, or phonological structure. Retrieval success was investigated by comparing recognition performance across the four conditions and/or between groups. Retrieval experience was investigated by using a "remember/know" (R/K) recognition procedure; R responses index retrieval that is accompanied by a "re-experiencing" of aspects of the encoding episode whereas K responses index retrieval based on a feeling of familiarity. The retrieval content results suggest that the retrieval of category specific information engages anterior cortical areas when the category is personally or socially relevant. The retrieval success results support previous suggestions of right frontal involvement. The retrieval experience results suggest that increases in frontal activity are more correlated with K responses than R responses. Additional frontal regions may be recruited for K responses to verify and monitor the output, and to engage additional strategic search processes to try to change K responses to R responses. R responses primarily engaged limbic regions and anatomically related structures that may deliver their output to right frontal regions or be "switched on" by them. The PET results converge with the results of the two behavioral studies. Relative to young adults under full attention, the R scores of old adults were smaller in only the self-reference and social desirability conditions, and young adults who divided their attention at retrieval performed similarly to old adults; previous studies have suggested that divided attention and aging affect frontal function. The present series of experiments shed light on the neuro-cognitive system that mediates the retrieval of self-referential information. The experiments revealed different components of episodic memory that contribute to the cognitive processes and patterns of neural activity associated with episodic memory for personally relevant information.
Tools not rules, cultivating practices of resistance to and prevention of sexualized violence

This thesis proposes that feminist thinking and practice concerning prevention of sexualized violence has too often limited itself to strategies such as breaking the silence or legal reform, without including, in both theory and practice, self-defense as a practical, effective, and empowering assault prevention tool for women. While women are raped daily, they also fight back daily, they use a variety of verbal and physical techniques: they yell, reason, plead with their attackers, and they flee, punch, kick and seriously hurt their would-be rapists. This work explores why it is, in this time of virtual explosion of writings on violence against women, that with extremely few exceptions, there is so little writing on this resistance? Why and how has women's resistance to violence been rendered invisible, within broader society, but more centrally here, within feminist discourse, as well? Finally, what are the effects of this invisibility on women's thinking and practice concerning resistance to sexualized violence? This thesis explores two co-implicated strands of this issue. On the one hand it addresses the absence of resistance and prevention in feminist anti-violence theorizing and practice. This part of the thesis is a critique-based project, looking at existing texts and practices with an aim to understand how and why resistance and prevention are such marginal concepts in a field in which one would imagine them to be central. This critique provides a theoretical based from which to examine feminist 'resistance to prevention.' Secondly, the thesis theorizes resistance and prevention in a way which provides theory and tools for practice where they have not previously existed, or existed only marginally.
Continuous caster scheduling, an optimization approach using column generation

Scheduling of certain major production operations remains a chronic concern for integrated steel producers. One operation in particular, the twin strand Continuous Slab Caster, is a major contributor to overall plant profitability when utilized effectively. In this thesis, we describe the optimization based heuristic that has been implemented to support Continuous Caster scheduling needs at Dofasco Inc. (Hamilton, Ontario, Canada). The basic scheduling problem addressed is a variation of the multiple Travelling Salesman Problem with competing objectives and complex, cross tour synchronization constraints. An integer programming formulation for this scheduling problem is presented and a decomposition and column generation based heuristic solution strategy is described. The quality of the heuristic model is evaluated using statistical methods for optimal solution value estimation. In addition, economic benefits of using this approach, estimated at $1.7 million per year, are developed from direct comparison with real production schedules, using actual production system measures.
Second death in Venice, cognitive mapping in the Venetian fictions of Jeanette Winterson, Ian McEwan, and Robert Coover

Venice has long been a privileged site for writers in English, but for much of this century, it seemed there was little left to say. Since 1980, however, there has been a marked return to Venice as a literary setting, and this thesis examines the material conditions-cultural, political, historical, and geographical-that are responsible for that return. It considers the creative interdependence of city and culture, and their intersection with Venetian topography in contemporary literature, specifically in Ian McEwan's ' The Comfort of Strangers', Jeanette Winterson's 'The Passion ', and Robert Coover's 'Pinocchio in Venice'. The new twentieth-century cities are being mapped and produced by contemporary writers of fiction like Angela Carter, Paul Auster, Bret Easton Ellis, and William Gibson, and theorists like Marshall Berman, Edward Soja, Elizabeth Grosz, and Christine Boyer, who are interpreting and making sense of our urban state of mind much as Baudelaire and Dickens, Mayhew and Engels, made sense of that of the nineteenth. Such mapping shapes the thinking in this thesis, and the new Venetian novels are unquestionably part of this same broad literary continuum, but at the same time they are situated, quite literally, elsewhere. While these texts are seen as a return of the repressed other of an earlier literary Venice and hence as driven by the compulsion to repeat, they are also (and perhaps more importantly) seen as moves toward a cognitive mapping of an as yet illegible, shifting, and bewildering landscape. McEwan, Winterson, and Coover discover in Venice a means of articulating a late-twentieth-century or the edge city of postmodernity, but from within the contained symbolic landscape of the medieval city/Renaissance urbs that is Venice. Through the reading and deconstruction of existing maps/writings/readings of a clearly articulated, legible city whose mythologized history can be traced back at least fifteen centuries and which has changed little topographically since the Renaissance, these writers map--and shape--an as yet uncharted late-twentieth-century mind shift.
Petrography and structural petrology of the Aldermac Syenite Igneous Complex and its related dikes

An alkaline igneous pluton, locally known as the Syenite Igneous Complex (SIC), and a petrologically similar dike swarm, are intruded into host volcanic rocks of the Blake River Group, near Aldermac, Quebec. The lithologically heterogeneous SIC consists of variously striking vertical sheets, and the related dikes are also vertical and generally radiating around the SIC. Both dikes and SIC are thought to be in their original emplacement orientation. All are characterised by primary igneous megacrysts that often exhibit a strong shape-preferred orientation (SPO). Petrographic and textural analyses indicate fractionation of magma at all scales, including late stage extrusion of residual melt (filter pressing). SPOs preserved in dikes and tabular bodies within the SIC, record a progressive history of freezing of magma in tabular intrusive bodies, inhibition of megacryst rotation by flow margins and grain interactions, late stage filter pressing of the magma, and ultimate channelling along discrete tubes.
Direct binding of dopamine D5 with GABA¦A receptors enables ligand gated and G-protein coupled receptor cross-talk

GABAA and dopamine DI/D5 receptors represent two structurally and functionally divergent families of neurotransmitter receptors, the former comprises a class of ligand gated ion channels responsible for fast inhibitory synaptic transmission while the latter belongs to a receptor superfamily exerting its biological effects via G-protein coupled signaling cascades. Trans-synaptic dopaminergic activation of both pre- and post-synaptic D1 or D5 receptors is thought to modulate GABAA receptor-mediated synaptic activity and neuronal excitability by intracellular cAMP and protein kinase dependent pathways. We report here that direct coupling between the carboxyl terminal [CT] domain of subtype-specific dopamine D5 receptor with the second intracellular loop of the GABAA receptor <math> <f> <g>g</g></f> </math>2 subunit provides an additional mean by which ligand-gated ion channel and G-protein linked receptor cross-talk is achieved. Fusion proteins encoding the cytoplasmic CT domain of dopamine D5, but not D1 receptors, precipitated native hippocampal GABAA receptors and bound directly to the second intracellular loop of <math> <f> <g>g</g></f> </math>2, but not <math> <f> <g>a</g></f> </math>1 or <math> <f> <g>b</g></f> </math>2 subunits of GABAA receptors. Subtype-selective and reciprocal functional receptor cross-talk, as indexed by dopamine D5, but not D1, attenuated GABAA (<math> <f> <g>a</g></f> </math>1<math> <f> <g>b</g></f> </math>2<math> <f> <g>g</g></f> </math>2) receptor whole-cell currents and GABAA receptor modulated reductions of D5-mediated cAMP accumulation in co-tranfected HEK-293 cells, required the presence of GABAA receptor <math> <f> <g>g</g></f> </math>2 subunits and is competitively inhibited by mini-genes encoding sequences of either the dopamine D5-CT tail or the second intracellular loop of the <math> <f> <g>g</g></f> </math>2 subunit. Direct protein-protein binding between domains of structurally and functionally divergent receptor classes highlights a previously unappreciated mechanism whereby subtype-specific receptors can act in concert to regulate synaptic strength and signal transduction. Moreover, the data provide a molecular framework in which to view GABAA and dopamine D1-like receptor interactions, aberrations of which are thought to underlie the maintenance and expression of cognitive elements in neuropsychiatric disease states such as schizophrenia.