VictorJuiz/thesis huggingface dataset:
Inuit Self-determination and Postsecondary Education: The Case of Nunavut and Greenland

With Inuit identifying as a people beyond nation-state boundaries, and Nunavummiut and Greenlanders as citizens of Canada and Denmark, the right to self-determination has followed distinct trajectories in the jurisdictions examined in my thesis. Nunavut has a constitutional mandate to be responsive to the Nunavut Land Claims Agreement, paradoxically intensifying the relationships with the federal government towards further devolution and maintaining an ethnic divide trespassing territorial lines. Envisioning statehood, Greenland has chosen to gradually break economic ties with Denmark and in mainstreaming its governance capacity it appears to be branching off ethnocentric policies. In what seem opposing pathways, autonomous postsecondary education institutions are positioned to mitigate the notional extremes the right to self-determination calls upon. By comparing institutions steering through conflicting missions, this thesis illustrates the ways in which the right to self-determination operates against the backdrop of regained geopolitical prominence of the Arctic Region. Applying a legal theoretical framework to the scholarship of indigenous education this thesis raises a number of issues in carrying forward the right to self-determination once indigenous peoples regain control over their destinies. Issues regarding social stratification challenging the politics of representation indicate that achieving some form of autonomy does not necessarily result in social justice as the indigenous rights advocacy scholarship suggests. Considering the Inuit right to self-determination as a process right rather than an outcome, this finding highlights internal pluralities challenging the reification of Inuit identity on the basis of cultural, political, and socioeconomic difference. This thesis advocates for examining the contingencies that shape Inuit multiple allegiances accounting for peoples vantage geopolitical positioning. As Inuit redefine their position in the local, national, and global spheres, important knowledge is produced overcoming the single overriding of identity politics. Recognizing that Inuit knowledge is knowledge in context, the author contends, may lead to new ways for postsecondary education to uphold the Inuit right to self-determination.

Keywords: indigenous self-determination
postsecondary education
Advisor: Sá, Creso
Web-based Concordancing and Other Reference Resources as a Problem-solving Tool for L2 Writers: A Mixed Methods Study of Korean ESL Graduate Students’ Reference Resource Consultation

The present study investigated how 6 Korean graduate students at a Canadian university used a suite of multiple Web-based reference resources (named i-Conc), consisting of concordancers and dictionaries, as a cognitive tool for solving linguistic problems encountered over the course of completing—in English, their second language (L2)—an academic writing assignment for one of their graduate courses. Using a mixed methods design employing surveys, interviews, screen recordings, a query tracking log, and detailed case studies, the thesis provides rich descriptions of (a) the processes, and outcomes of the 6 participants’ uses of i-Conc as a reference tool for their writing authentic academic tasks and (b) their perceptions of the suite as a means of writing assistance. Overall, i-Conc served as an intellectual partner that aided the participants in strategically solving lexical and grammatical problems during their writing assignments: About 70 % of the problems they addressed with i-Conc resulted in correct text formulations or revisions. The different resources in i-Conc were each shown to have unique functions for which they were best suited, suggesting that concordancing may optimally be consulted in combination with, not in place of, other resources. The benefits of consulting i-Conc for L2 writing went beyond simply helping the participants’ problem solving to potentially facilitating their language acquisition. Input-feedback interactions with the reference suite prompted the participants to carry out robust meaning negotiations in their efforts to verify their intuitive hypotheses and to venture beyond their current linguistic repertoires. Participants acted on these potential benefits somewhat differently. Case studies and cross-case analyses demonstrated complex interactions between the participants’ individual traits and goals, the educational contexts for which they were writing, and their perceptions and evaluations of particular affordances provided by i-Conc. These findings imply that to build meaningful cognitive partnerships with reference tools, L2 writers should receive progressive guidance on principles for effective reference resource consultation along with training in strategies for using different types of resources, contingent on individuals’ abilities and ongoing needs arising from their macro and micro contexts for writing and for language learning.

Keywords: concordancing
corpus tool
L2 writing
cognitive tool
reference resource
Advisor: Cumming, Alister
"Attention and Conscious Perception"

Are we conscious of more than what's in the “spotlight” of attention, or is consciousness limited to the content of attention? Recently several authors (DeBrigard & Prinz 2011; Prinz 2010; Dennett & Cohen 2012) have defended the view that attention to some object is necessary for conscious perception of that object. For each of these authors, attention acts like more than just a “spotlight on a stage.” But none of them provides a robust account of this new way of attending. My project offers a new theory of diffuse attention that explains the apparent richness of experience. Accepting that there is a diffuse way of attending requires us to abandon the notion of attention as a spotlight. On the view that I offer, attention has degrees. For example, when looking at a landscape, your attention is spread over a broad spatial area and details are more difficult to remember or describe than when you focus attention in greater depth on some object within that landscape. A broad and shallow diffusion of attention nonetheless makes its object available for guiding thought and action, and so should be considered a way of attending rather than merely being conscious. After defending a theory of diffuse attention, I offer a new argument for the view that attention is necessary for conscious perception. My argument is motivated by the phenomenological observation that ordinary perceptual experience has a structure: some objects are in the foreground of experience, while others are in the background. I motivate the claim that this foreground/background structure is necessary for perceptual experience, and argue that focal and diffuse attention provide the foreground/background structure. I conclude that attention is necessary for perceptual experience, since it provides a necessary structure of experience. In making this argument, I draw on phenomenological insight into the structure of consciousness from James (1890), Gurwitsch (1964; 1966) and C.O. Evans (1970). For each of these authors, attention structures the foreground – but not the background – of consciousness. My novel contribution is to provide an account of how attention structures the conscious background. By enriching the concept of attention to include diffuse attention, my account is poised to explain the structure of conscious experience from foreground to background.

Keywords: attention
consciousness
Advisor: Thompson, Evan
How Hospital Registered Nurses Learn About Drug Therapy for Older Adults

Although older Canadians constitute a large portion of patients in hospital, many receive less-than-optimal drug care. Most registered nurses (RNs) and other health care professionals who provide older adults (OAs) with drug therapy lack pre-professional education about that practice. Concurrently, there is little research available about how RNs learn about drug therapy for OAs. Using a qualitative method, this thesis explores hospital RNs’ insights about their knowledge about drug therapy for OAs, their associated learning needs and strategies, and contextual influences on their learning. The findings illuminated RNs’ extensive knowledge, their learning needs and varied learning strategies, and constraints and facilitators of their learning. Drug therapy for OAs is a complex activity. RNs play a pivotal role in that care and have ample knowledge. RNs’ learning is holistic, ongoing, mostly informal, and reflective of many adult-learning theories. By learning, RNs build and transform their repertoires of knowledge to stay current with the quickly changing landscapes of health care, gerontological know-how, and drugs and drug practices. As a result, sometimes RNs protect not only OAs but also other hospital stakeholders from the negative effects of uninformed practice. Nurse educators should teach students about drug therapy for OAs and broaden their own views about RNs’ knowledge and learning strategies for that care. Nurse leaders should maximize chances for RNs to learn and prepare them to influence other stakeholders in ways that support learning. Hospital administrators and other stakeholders should recognize RNs’ pivotal role in drug care and support their learning through organizational changes. Communities should design strategies that ease RNs’ learning. Policymakers should replace corporatism with innovations that champion learning. Researchers and RNs should collaborate on novel projects that bolster RNs’ learning.

Keywords: hospital registered nurses
learning
drugs and older adults
Advisor: Ryan, James
Western Teachers of Science or Teachers of Western Science: On the Influence of Western Modern Science in a Post-colonial Context

An expanding body of research explores the social, political, cultural and personal challenges presented by the Western emphasis of curricula around the world. The aim of my study is to advance this field of inquiry by gaining insight into perceptions of Western modern science presented by students, teachers and administrators in a given Caribbean setting. Through this study I asked how my research participants described the nature of scientific knowledge, how they related scientific knowledge to other culturally-valued knowledges and the meanings they attached to the geographic origins of science teachers. Situating this work firmly within the practice of Foucauldian critical discourse analysis, I have utilised a conceptual framework defined by the power/knowledge and complicity/resistance themes of post-colonial theory to support my interpretation of participant commentary in an overall quest that is concerned about the ways in which Western modern science might be exerting a colonising influence. Fourteen students, nine teachers (both expatriate and local) and three administrators participated in the study. I combined a semi-structured question and answer interview format with a card sort activity. I used a procedure based on my own adaptation of Stephenson’s Q methodology, where the respondents placed 24 statements hierarchically along a continuum of increasing strength of agreement, presenting their rationalisations, personal stories and illustrations as they sorted. I used an inverse factor analysis, in combination with the interview transcripts, to assist me in the identification of three discourse positions described by my research participants: The truth value of scientific knowledge, The pragmatic use of science to promote progress, and The priority of cultural preservation. The interview transcripts were also analysed for emergent themes, providing an additional layer of data interpretation. The research findings raise concerns regarding the hegemonic potency of certain scientific assumptions and assertions of participants, leading me to emphasise the importance of developing teachers’ knowledge of the historical, philosophical and social background of Western modern science as well as focusing on developing the conceptual and intellectual engagement of students with Western modern science without demanding the kind of belief commitment that would insist that students replace alternative modes of meaning making.

Keywords: Science Education
Post-colonial Theory
Discourse
Advisor: Wallace, John
Factors Affecting the Growth and Fragmentation of Polyferrocenylsilane Diblock Copolymer Micelles

Polyferrocenylsilane (PFS) diblock copolymers self-assemble in selective solvents to form one-dimensional micelles for a broad range of polymer compositions and experimental conditions, driven by the crystallization of the PFS block that forms the micelle core. The most striking feature of these micelles is that they remain active for further growth. They can be extended in length when additional polymer, dissolved in a good solvent, is added to a solution of the pre-existing micelles. This thesis describes several studies investigating the factors that affect the growth and fragmentation of PFS diblock copolymer micelles in solution, with a particular emphasis on polyisoprene-PFS (PI-PFS) diblock copolymers. The goal of my research was trying to provide deeper understanding of this crystallization-driven self-assembly (CDSA) process. In an attempt to understand the growth kinetics of the PI-PFS cylindrical micelles, I added tiny amount of short micelle seeds into supersaturated solution of the same polymer, and followed the micelle growth by light scattering. The data analysis showed that the increase of micelle length could be described by an expression with two exponential decay terms. In another attempt to examine the factors that may affect the growth behavior of the PI-PFS micelles, I found that PI-PFS long micelles underwent fragmentation when they were subjected to external stimuli, e.g. addition of polar solvent, or heating. During the course of studying the effect of heating on the micelles, I developed a new approach to generate cylindrical micelles with controllable and uniform length, a one-dimensional analogue of self-seeding of crystalline polymers. I carried out a systematic study to investigate the self-seeding behavior of PFS block copolymers.

Keywords: Self-assembly
Polyferrocenylsilane
Block copolymers
Cylindrical micelles
Advisor: Winnik, Mitchell
Altered DNA Repair, Antioxidant and Cellular Proliferation Status as Determinants of Susceptibility to Methylmercury Toxicity in Vitro

Methylmercury (MeHg) is a pervasive environmental contaminant with potent neurotoxic, teratogenic and likely carcinogenic activity, for which the underlying molecular mechanisms remain largely unclear. Base excision repair (BER) is important in mitigating the pathogenic effects of oxidative stress, which has also been implicated in the mechanism of MeHg toxicity, however the importance of BER in MeHg toxicity is currently unknown. Accordingly, we addressed this question using: (1) spontaneously- and Simian virus 40 (SV40) large T antigen-immortalized oxoguanine glycosylase 1-null (Ogg1-/-) murine embryonic fibroblasts (MEFs); and, (2) human Ogg1 (hOgg1)- or formamidopyrimidine glycosylase (Fpg)-expressing human embryonic kidney (HEK) cells; reciprocal in vitro cellular models with deficient and enhanced ability to repair oxidatively damaged DNA respectively. When spontaneously-immortalized wild-type and Ogg1-/- MEFs were exposed to environmentally relevant, low micromolar concentrations of MeHg, both underwent cell cycle arrest but Ogg1-/- cells exhibited a greater sensitivity to MeHg than wild-type controls with reduced clonogenic survival and increased apoptosis, DNA damage and DNA damage response activation. Antioxidative catalase alleviated the MeHg-initiated DNA damage in both wild-type and Ogg1-/- cells, but failed to block MeHg-mediated apoptosis at micromolar concentrations. As in spontaneously immortalized MEFs, MeHg induced cell cycle arrest in SV40 large T antigen-immortalized MEFs, with increased sensitivity to MeHg persisting in the Ogg1-/- MEFs. Importantly, cells seeded at a higher density exhibited compromised proliferation, which protected against MeHg-mediated cell cycle arrest and DNA damage. In the reciprocal model of enhanced DNA repair, hOgg1- and Fpg-expressing cells appeared paradoxically more sensitive than wild-type controls to acute MeHg exposure for all cellular and biochemical parameters, potentially due to the accumulation of toxic intermediary abasic sites. Accordingly, our results provide the first evidence that Ogg1 status represents a critical determinant of risk for MeHg toxicity independent of cellular immortalization method, with variations in cellular proliferation and interindividual variability in antioxidative and DNA repair capacities constituting important determinants of risk for environmentally-initiated oxidatively damaged DNA and its pathological consequences.

Keywords: Toxicology
DNA Damage
DNA Repair
Reactive Oxygen Species
Antioxidants
Methylmercury
Catalase
Oxoguanine Glycosylase 1
Cell Culture
Cellular Proliferation
Oxidative Stress
Formamidopyrimidine Glycosylase
Gamma H2AX
8-oxo-2'-deoxyguanosine
Cellular Immortalization
Base Excision Repair
Advisor: Wells, Peter G.
Detecting Emotional Response to Music using Near-infrared Spectroscopy of the Prefrontal Cortex

Many individuals with severe motor disabilities may not be able to use conventional means of emotion expression (e.g. vocalization, facial expression) to make their emotions known to others. Lack of a means for expressing emotions may adversely affect the quality of life of these individuals and their families. The main objective of this thesis was to implement a non-invasive means of identifying emotional arousal (neutral vs. intense) and valence (positive vs. negative) by directly using brain activity. In this light, near infrared spectroscopy (NIRS), which optically measures oxygenated and deoxygenated hemoglobin concentrations ([HbO2] and [Hb], respectively), was used to monitor prefrontal cortex hemodynamics in 10 individuals as they listened to music excerpts. Participants provided subjective ratings of arousal and valence. With respect to valence and arousal, prefrontal cortex [HbO2] and [Hb] were characterized and significant prefrontal cortex hemodynamic modulations were identified due to emotions. These modulations were not significantly related to the characteristics of the music excerpts used for inducing emotions. These early investigations provided evidence for the use of prefrontal cortex NIRS in identifying emotions. Next, using features extracted from [HbO2] and [Hb] in the prefrontal cortex, an average accuracy of 71% was achieved in identifying arousal and valence. Novel hemodynamic features extracted using dynamic modeling and template-matching were introduced for identifying arousal and valence. Ultimately, the ability of autonomic nervous system (ANS) signals including heart rate, electrodermal activity and skin temperature to improve the identification results, achieved when using PFC [HbO2] and [Hb] exclusively, was investigated. For the majority of the participants, prefrontal cortex NIRS-based identification achieved higher classification accuracies than combined ANS and NIRS features. The results indicated that NIRS recordings of the prefrontal cortex during presentation of music with emotional content can be automatically decoded in terms of both valence and arousal encouraging future investigation of NIRS-based emotion detection in individuals with severe disabilities.

Keywords: Biomedical Engineering
Brain Computer Interface
Advisor: Tom, Chau
Marie, Guerguerian Anne
Development and Intratumoral Distribution of Block Copolymer Micelles as Nanomedicines for the Targeted Delivery of Chemotherapy to Solid Tumors

Recent advancements in pharmaceutical technology based on principles of nanotechnology, polymer chemistry, and biomedical engineering have resulted in the creation of novel drug delivery systems with the potential to revolutionize current strategies in cancer chemotherapy. In oncology, realization of significant improvements in therapeutic efficacy requires minimization of drug exposure to healthy tissues and concentration of the drug within the tumor. As such, encapsulation of chemotherapeutic agents inside nanoparticles capable of enhancing tumor-targeted drug delivery is a particularly promising innovation. Yet, initial investigations into the intratumoral fate of nanomedicines have suggested that they may be heterogeneously distributed and achieve limited access to cancer cells located distant from the tumor vasculature. As such, uncovering the determinants of nanoparticle transport at the intratumoral level is critical to the development of optimized delivery vehicles capable of fully exploiting the therapeutic potential of nanomedicines. In this work, the chemotherapeutic agent, docetaxel (DTX), was incorporated into nano-sized, biocompatible PEG-b-PCL block copolymer micelles (BCMs). Encapsulation of DTX in micelles via chemical conjugation or physical entrapment resulted in a dramatic increase in drug solubility and customizable drug release rate. The use of multicellular tumor spheroids (MCTS) was established as a viable platform for assessing the efficacy and tumor tissue penetration of nanomedicines in vitro. A series of complementary assays was validated for analysis of DTX-loaded micelle (BCM+DTX) toxicity in monolayer and spheroid cultures relative to Taxotere®. Cells cultured as spheroids were less responsive to treatment relative to monolayer cultures due to mechanisms of drug resistance associated with structural and microenvironmental properties of the 3-D tissue. Computational, image-based methodologies were used to assess the spatial and temporal penetration of BCMs in spheroids and corresponding human tumor xenografts. Using this approach, the tumor penetration of micelles was found to be nanoparticle-size-, tumor tissue type- and time- dependent. Furthermore, spheroids were found to be a valuable platform for the prediction of trends in nanoparticle transport in vivo. Overall, the results reported herein serve to demonstrate important determinants of nanoparticle intratumoral transport and to establish computational in vitro and in vivo methodologies for the rational design and optimization of nanomedicines.

Keywords: cancer
nanoparticle
nanomedicine
block copolymer micelle
chemotherapy
biomaterials
tumor
tumor penetration
tumor distribution
docetaxel
Taxotere
targeted delivery
Advisor: Allen, Christine