VictorJuiz/thesis huggingface dataset:
The Role of Emotion Regulation in the Expressive Writing Intervention

Expressive Writing (EW) involves asking participants to write emotionally about stressful life events and has been associated with improvements in psychological and physical health. The purpose of the current study was to extend previous work by examining the moderating and mediating role of emotion regulation within the EW intervention. Sixty participants who had experienced a traumatic event were recruited from the community and were assigned to an EW or control writing condition. Measures assessing emotion regulation and indices of psychological and physical health were administered at baseline and one month follow-up to determine changes in symptomatology. In comparison to control writing, EW led to significant improvements in depression, emotional clarity, and to a lesser degree emotional awareness. Although no other group differences were found, all participants demonstrated significant improvements in their symptoms of posttraumatic stress, reported physical health, overall emotion regulation abilities, their ability to accept their emotions, engage in goal directed behaviour when distressed, and access emotion regulation strategies they perceive as effective. No support was found for our moderation hypothesis. However, a significant moderation was discovered revealing that difficulties engaging in goal directed behaviour when distressed moderated improvements in posttraumatic stress symptoms. Specifically, control participants with this emotion regulation deficit demonstrated significantly poorer outcomes than control participants without this deficit; in comparison to the EW group participants who improved similarly on posttraumatic stress symptoms regardless of their level of difficulties at baseline engaging in goal directed behavour when distressed. Additionally, baseline emotion regulation abilities predicted improvements on psychological health (but not physical health) outcome measures for both groups. No support was found for our mediation hypothesis. Exploratory analyses revealed that the EW group demonstrated greater emotional arousal in response to their writing in sessions 1 and 2, but that by session 3 their arousal had significantly decreased and was equivalent to that of the control group, which showed no changes in arousal across sessions. No support was found for the moderating or mediating influence of arousal on outcome. Results will be discussed within a model of emotional expression and emotion regulation and compared to the existing EW literature.

Keywords: expressive writing
emotion regulation
emotionally expressive writing
affect regulation
trauma
posttraumatic stress disorder
Advisor: Watson, Jeanne
The Beneficial Effects of Hypercapnia, and the Detrimental Effects of Peroxynitrite, in Chronic Neonatal Lung Injury

Bronchopulmonary dysplasia (BPD) is a chronic neonatal lung injury (CNLI) affecting infants of < 32 weeks gestation, which has a significant associated morbidity and mortality. The hallmarks of BPD as seen in the current era are arrested alveologenesis and parenchymal thickening. Those most severely affected may develop pulmonary hypertension which worsens the prognosis. No effective preventive therapy exists. Generation of damaging reactive oxygen species is implicated in its development. The more recently recognized reactive nitrogen species may also contribute to this disease. Thus, there is considerable interest in preventive antioxidant therapies, but results to date have not been promising. Newborn rats, exposed to 60% O2 for 14 days, develop a parenchymal injury and pulmonary hypertension that resembles the morphological features of human BPD. Previous studies have shown that following exposure to 60% O2, a pulmonary influx of neutrophils is followed by that of macrophages. Inhibiting the influx of neutrophils prevents the generation of reactive oxygen species, while simultaneously enhancing postnatal lung growth. Other interventions have shown that development of pulmonary hypertension is dependent upon increases in both 8-isoprostane and its downstream regulator of vascular tone, endothelin-1. Gentler ventilation strategies, incorporated to minimize induction of stretch-mediated pro-inflammatory cytokines, have shown benefits of permissive hypercapnia in adult lung injury. Multicentre clinical trials of permissive hypercapnia in neonates have not shown benefit. Therapeutic hypercapnia has been demonstrated to have a protective effect of PaCO2 in both acute studies of ventilator-induced and ischemia-reperfusion injuries in animal models. In the studies reported herein, therapeutic hypercapnia was found to completely protect against CNLI and attenuate 60% O2-induced macrophage-derived protein nitration. The likely nitrating agent was macrophage-derived peroxynitrite. The critical role of peroxynitrite, in the development of chronic neonatal lung injury in this model, was confirmed using a peroxynitrite decomposition catalyst. This protected against the impairments of alveolarization and of pulmonary vascularization induced by 60% O2. These results suggest a more significant role for reactive nitrogen species than previously recognized. Finally, preliminary evidence is presented supporting a role for neutrophil-derived elastase in initiating the macrophage influx in the lungs, required for peroxynitrite generation, during 60% O2-mediated injury.

Keywords: Alveolar formation
Bronchopulmonary dysplasia
Carbon dioxide
Chronic neonatal lung injury
Inflammation
Lung growth
Oxygen toxicity
Pulmonary hypertension
Free radicals
Advisor: Tanswell, Keith
A Matter of Character: Moral Psychology and Political Exclusion in Kant and Mill

What kind of agent does liberal political thought presuppose? Who is the subject inhabiting modern, liberal conceptions of political order? This dissertation is a study of liberal character-formation, of the kinds of persons, subjects and citizens underlying seminal works in the liberal tradition. More specifically, it explores the forms of character and agency sustaining Immanuel Kant’s and John Stuart Mill’s moral and political philosophies, as well as problems of exclusion and marginalization faced by agents who are, either naturally or circumstantially, unable to develop a properly liberal character. The project is guided by three central aims. The first is expository: the dissertation draws to light the substantial attention that Kant and Mill both devoted to the moral psychology of progressive, liberal agency, and to the conditions, processes and mechanisms forming a liberal character. The second aim is critical, examining the ways in which these ideals of liberal character stand to constrain the inclusiveness and equality at the centre of liberal moral and political doctrines. The final aim is evaluative, reflecting on how we might situate problems of exclusion, both within the broader architectures of Kant’s and Mill’s respective philosophical systems, and in relation to the liberalisms that we inherit from them.

Keywords: political theory
history of political thought
liberalism
moral psychology
imperialism
exclusion
character
agency
Immanuel Kant
John Stuart Mill
Advisor: Ronald, Beiner
A Case Study of Compact Core French Models: A Pedagogic Perspective

The overriding objective of core French (CF) teaching in Canada since the National Core French Study (NCFS) is that of communicative competence (R. Leblanc, 1990). Results from the traditional form of CF, though, suggest that students are not developing desired levels of communicative competence in the drip-feed (short daily periods) model (Lapkin, Harley, & Taylor, 1993). The present study aims to investigate the role of compacted second language program formats in promoting higher levels of language proficiency and achievement among elementary core French students; in particular, the study investigates the pedagogic approach, based on the principle that longer class periods should facilitate a more communicative/ experiential teaching approach. Students in three Grade 7 classes served as participants. Two of the classes served as the compacted experimental classes, and the other as a comparison class. Pre-tests, immediate post-tests and delayed post-tests recorded differences in student achievement. A multi-dimensional, project-based curriculum approach was implemented in all three classes, and was recorded by teacher observations in her daybook and daily journal. Student attitudes toward their CF program format and their self-assessed language proficiency were measured during recorded focus group sessions and on student questionnaires. Parental and teacher perceptions of student attitudes were measured using a short survey. Results indicate that students in both the compact and comparison classes performed similarly, with few significant differences in measured language growth or retention over time. Parents of all classes indicated satisfaction with the teaching and learning activities, and with the program format in which their child was enrolled. Excerpts from the teacher daybook and reflective journal demonstrated that communicative activities fostering student interaction in the target language were more frequently and readily implemented in the longer compact CF periods. Students generally stated a preference for the program format in which they were enrolled, although only students in the compact classes outlined pedagogic reasons in support for their preference. Additionally, most students self-assessed a higher level of language competence than in previous years, which students in the compact (experimental) classes attributed to the longer class periods, stating that they promoted task completion, group work, in-depth projects and communicative activities.

Keywords: Core French
Second Language
Compact Language Models
Advisor: Lapkin, Sharon
Brain CYP2D6 and its role in Neuroprotection against Parkinson's Disease

The enzyme CYP2D6 can metabolize many centrally acting drugs and endogenous neural compounds (e.g. catecholamines); it can also inactivate neurotoxins such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 1,2,3,4-tetrahydroisoquinoline (TIQ) and β-carbolines that have been associated with Parkinson’s disease (PD). CYP2D6 is ideally situated in the brain to inactivate these neurotoxins. The CYP2D6 gene is also highly polymorphic, which leads to large variation in substrate metabolism. Furthermore, CYP2D6 genetically poor metabolizers are known to be at higher risk for developing PD, a risk that increases with exposure to pesticides. Conversely, smokers have a reduced risk for PD and smokers are suggested to have higher brain CYP2D6 levels. Our studies furthered the characterization and involvement of CYP2D6 in neuroprotection against PD. METHODS: We investigated the effects of CYP2D6 inhibition on MPP+-induced cell death in SH-SHY5Y human neuroblastoma cells. We compared levels of brain CYP2D6, measured by western blotting, between human smokers and non-smokers, between African Green monkeys treated with saline or nicotine, and between PD cases and controls. In addition, we assessed changes in human brain CYP2D6 expression with age. RESULTS: Blocking CYP2D6 activity in SH-SY5Y cells with four diverse inhibitors significantly increased MPP+-induced neurotoxicity. Smokers have higher brain CYP2D6 compared to non-smokers. In monkeys, basal expression of CYP2D6 varied across brain regions and was increased by chronic nicotine treatment in select regions (notably the basal ganglia) and specific cell types. Expression of human brain CYP2D6 increased from fetal to 80 years of age in the frontal cortex; the influence of age on CYP2D6 expression was brain region specific. Compared to age-matched controls, PD cases had ~40% lower CYP2D6 levels in the frontal cortex, cerebellum and hippocampus consistent with lower CYP2D6 increasing the risk for PD. In the caudate and substantia nigra, CYP2D6 levels were similar between PD case and controls using Western blotting. This is likely due to the increase in CYP2D6-expressing astrocytes and much higher cellular CYP2D6 in PD affected areas as observed with immunocytochemical staining. CONCLUSIONS: Brain CYP2D6 can meaningfully inactivate neurotoxins, and it can be increased by nicotine in brain regions of interest to PD. These findings support the contention that higher brain CYP2D6 is protective and lower levels may contribute to increased risk for PD.

Keywords: CYP2D6
Parkinson's disease
Nicotine
Smoking
Advisor: Tyndale, Rachel
Characterization of the White-rot Fungus, Phanerochaete carnosa, through Proteomic Methods and Compositional Analysis of Decayed Wood FibreCharacterization of the White-rot Fungus, Phanerochaete carnosa, through Proteomic Methods and Compositional Analysis of Decayed Wood Fibre

Biocatalysts are important tools for harnessing the potential of wood fibres since they can perform specific reactions with low environmental impact. Challenges to bioconversion technologies as applied to wood fibres include low accessibility of plant cell wall polymers and the heterogeneity of plant cell walls, which makes it difficult to predict conversion efficiencies. White-rot fungi are among the most efficient degraders of plant fibre (lignocellulose), capable of degrading cellulose, hemicellulose and lignin. Phanerochaete carnosa is a white-rot fungus that, in contrast to many white-rot fungi that have been studied to date, was isolated almost exclusively from fallen coniferous trees (softwood). While several studies describe the lignocellulolytic activity of the hardwood-degrading, model white-rot fungus Phanerochaete chrysosporium, the lignocellulolytic activity of P. carnosa has not been investigated. An underlying hypothesis of this thesis is that P. carnosa encodes enzymes that are particularly well suited for processing softwood fibre, which is an especially recalcitrant feedstock, though a major resource for Canada. Moreover, given the phylogenetic similarity of P. carnosa and P. chrysosporium, it is anticipated that the identification of pertinent enzymes for softwood degradation can be more easily conducted. In particular, this project describes the characterization of P. carnosa in terms of the growth conditions that support lignocellulolytic activity, the effect of enzymes secreted by P. carnosa on the chemistry of softwood feedstocks, and the characterization of the corresponding secretome using proteomic techniques. Through this study, cultivation methods for P. carnosa were established and biochemical assays for protein activity and quantification were developed. Analytical methods, including FTIR and ToF-SIMS were used to characterize wood samples at advancing stages of decay, and revealed preferential degradation of lignin in the early stages of growth on all softwoods analyzed. Finally, an in depth proteomic analysis of the proteins secreted by P. carnosa on spruce and cellulose established that similar sets of enzyme activities are elicited by P. carnosa grown on different lignocellulosic substrates, albeit to different expression levels.

Keywords: softwood degradation, white-rot fungus
P. carnosa, proteomics, ToF-SIMS, FTIR
Advisor: Master, Emma
Teaching and Learning in an Integrated Curriculum Setting: A Case Study of Classroom Practices

Curriculum integration, while a commonly used educational term, remains a challenging concept to define and examine both in research and in classroom practice. Numerous types and definitions of curriculum integration exist in educational research, while, in comparison, teachers tend to focus on curriculum integration simply as a mixing of subject areas. To better understand curriculum integration in practice, this thesis details a case study that examines both teacher and student perspectives regarding a grade nine integrated unit on energy. Set in a public secondary school in Ontario, Canada, I comprehensively describe and analyze teacher understandings of, and challenges with, the implementation of an integrated unit, while also examining student perspectives and academic learning. My participants consisted of two high school teachers, a geography teacher and a science teacher, and their twenty-three students. Using data gathered from interviews before, during, and after the implementation of a 16-lesson unit, as well as observations throughout, I completed a case description and thematic analysis. My results illustrate the importance of examining why teachers choose to implement an integrated unit and the planning and scheduling challenges that exist. In addition, while the students in this study were academically successful, clarification is needed regarding whether student success can be linked to the integration of these two subjects or the types of activities these two teachers utilized.

Keywords: curriculum integration
classroom practice
Advisor: Wallace, John
The Individualization of Risk as Responsibility and Citizenship: A Case Study of Chemical Body Burdens

This dissertation examines how changing conceptions of risk responsibility relate to changing ideas of citizenship and the public sphere. Using the empirical case study of chemical body burdens, and drawing on focus groups and in-depth interviews, in addition to a twenty-year framing analysis of Canadian news media coverage of environmental contamination, this dissertation examines how risks are individualized through an ideology of “precautionary consumption.” Precautionary consumption encourages self-protection through consumer-based vigilance (e.g., by buying organic produce or “natural” cleaning products) and shifts the focus away from the state’s responsibility to regulate human and environmental exposure to contaminants. Three key findings emerge from this research. First, over twenty years of Canadian media coverage, precautionary consumption is increasingly prominent in shaping the problem frame around chemical contamination. As a media frame, the ideology of precautionary consumption reconceptualises chemical body burdens as an environmental problem affecting everyone equally to an individual problem that afflicts unaware consumers. Second, interview data suggests that the practice of mediating individual exposure to chemicals is overwhelmingly characterized as a caregiving responsibility requiring a mother’s vigilance. Interview respondents interpreted this responsibility through a dual ideological lens comprised of intensive mothering and precautionary consumption. Interviews with mothers from low-income households furthermore suggest that practices of chemical mediation vary by social class, and that access to protective commodities is highly uneven. Third, interview data also suggest that respondents viewed vigilant shopping practices as part of accepting greater personal responsibility for chemical pollution as a health threat and larger environmental problem. Respondents dismissed the transformative potential of the state in addressing body burdens; in contrast, they expressed confidence in their power as consumers and in the responsiveness of the market to protect them from chemical threats. The concluding chapter of the dissertation discusses how precautionary consumption draws our attention away from the universality of risk, and the responsibilities of the state for managing body burdens as a collective risk.

Keywords: environmental sociology
consumer-citizenship
mothering
risk
Advisor: Johnston, Josée
Political Authority and Distributive Justice

Many political theorists agree that an equal distribution of certain goods is a requirement of justice. However, they disagree about the types of agents that possess these distributive obligations, and about the range of agents who owe these obligations to each other. Are states primarily responsible for ensuring a just distribution of income? Or, is distributive justice also the responsibility of private individuals? Do agents – whether states or individuals – possess distributive obligations to foreigners? Or, is distributive justice only a requirement within national borders? I argue that the primary subject of distributive justice is the state’s relation to its citizens. States, and not private individuals, possess distributive obligations; and states only possess these obligations to their citizens, not to foreigners. I argue first that the state possesses distinctive distributive obligations to its citizens because of the way in which it exercises political authority over them. To exercise its political authority legitimately, that is, in a way that is consistent with the free and equal nature of its citizens, I argue, the state must secure a just distribution of civil liberties, political rights, income, and opportunities. I argue second that the subject of distributive justice does not extend beyond the state’s relation to its citizens. I argue first that principles of distributive justice do not apply to the private choices of citizens on the grounds that justice demands that citizens be free to decide what to do with their lives on the basis of their own conception of the good, and not on the basis of what is best for others. I argue second that because international organizations do not exercise political authority in the same way that states do, equality is not a demand of global justice.

Keywords: Political Authority
Distributive Justice
The Subject of Distributive Justice
Advisor: Ripstein, Arthur
Philosophy of the Many: High School Philosophy and a Politics of Difference

As we start a new millennium, the conviction that exclusionary practices need to be fought at all levels of society is becoming gradually more accepted. Nevertheless, as I show in this thesis, many if not most researchers on High School Philosophy (HSP) operate from what Iris Marion Young (1990) calls a logic of identity, which continues to be exclusionary even when it attempts to reach “all.” My objective in this thesis, therefore, is to map out the HSP literature in terms of Young’s “Politics of Difference,” and, by doing that, to suggest ways in which it could be more inclusive. This adaptation of Young’s Politics of Difference to HSP is presented in this thesis in six chapters. In chapter 1, I summarize the main aspects of Young’s argument. In chapter 2, I give an overview of the current literature on HSP, showing that it is scarce and scattered. This thesis’s first contribution, therefore, is as a representative, though not exhaustive, catalogue of the HSP literature. In chapter 3, I present a deeper analysis of the HSP literature, dividing it into two main strands, “the selective” and the “universal” approaches to HSP. I also argue in this chapter that both these approaches are problematic, because they exclude many, privileges some over others and alienate all. In chapter 4, I present a brief analysis of the epistemology informing both the selective and the universal approaches to HSP. In this chapter, I focus on the so-called “Myth of Neutrality,” which is another manifestation of the logic of identity. Using as illustration the works of two authors, Robert Simon and Harvey Siegel, I show in this chapter how the myth of neutrality manifests the positivism and reductionism typical of the logic of identity. Finally, in chapter 5 I present my positive proposal for HSP, which I called “Philosophy of Many” (PoM), as a more inclusive alternative to both the selective and the universal approaches to HSP. The final chapter reviews the main conclusions of this study and suggests direction for further research.

Keywords: high school philosophy
politics of difference
social justice
inclusion
Advisor: Boyd, Dwight