VictorJuiz/thesis huggingface dataset:
The representation of bodily pain in late nineteenth-century English culture

This dissertation presents a study of the ways in which concepts of pain were treated across a broad range of late Victorian writing, placing literary texts alongside sermons, medical textbooks and campaigning leaflets, in order to suggest a pattern of representation and evasion to be perceived throughout the different texts assembled. In the first two chapters I establish the cultural and historical background to physical suffering in the late nineteenth century, as the Christian paradigm for suffering (the subject of the first chapter) lost its pre-eminance to that of medicine (Chapter Two). The next two chapters are concerned with the problem of the expressibility of pain. In Chapter Three I argue that despite popular belief, voiced most clearly by Virginia Woolf, that 'there is no language for pain', sufferers find language that is both metaphorical and directly referential to express their bodily suffering. Chapter Four takes up the cultural restrictions placed on the expression of pain, using the acrimonious debate over vivisection that arose at the end of the century. Bringing together the prolific texts of both vivisectionists and antivivisectionists, I display the possibilities and limitations of particular literary forms, arguing, for example, that language appropriate to medical textbooks proved to be too shocking in books with a wider circulation. The final chapter is concerned with the ways in which pain was schematised in the last two decades of the nineteenth century. I explore the basis of belief in pain as a shared, cross-cultural phenomenon and make the case, using the examples of invertebrate neurology, fire-walking and tattooing, that the understanding of pain is sharply affected by class, gender, race and supposed degree of criminality, despite the fact that pain is often invoked as a marker of shared human identity.
Incomparability and practical reason

In this thesis I aim to answer two questions: Are alternatives for choice ever incomparable? and, In what ways can items be compared? I argue that there is no incomparability among bearers of value and that the ways in which items can be compared are richer and more varied than commonly supposed. The two questions are closely related; in arguing against incomparability a positive picture of comparability emerges. The case against incomparability is a case for a new conception of comparability more capacious than has been traditionally conceived. This 'broad' conception of comparability has three distinctive features: it distinguishes incomparability from noncomparability, it includes the possibility of 'emphatic' comparability, or comparisons between 'higher' and 'lower' goods; and it makes logical space for a fourth generic value relation - what I shall call 'on a par' - beyond the standard trichotomy of relations of 'better than', 'worse than', and 'equally good'. Each of these features arises out of defects of certain incomparabilist arguments. Indeed, the approach to the broad conception of comparability via examination of incomparabilist arguments makes clear that much of the intuitive pull of incomparability depends on a narrow and impoverished conception of comparability.
Investigation of comparability and incomparability is motivated by a proposed substantive account of practical justification according to which there can be no justified choice without the comparability of the alternatives. The existence of widespread incomparability, then, undermines the rationality of practical life. This thesis' argument against incomparability and for a broad conception of comparability serves to vindicate the role of practical reason in choice.
Aspects of dark matter phenomenology

Identifying the relic particles that constitute the cold dark matter in our Universe is an outstanding problem in astro-particle physics. Direct detection experiments are among the most promising methods of detecting particle dark matter through non-gravitational interactions. In this thesis, the usual assumptions made when calculating the event rate at direct detection experiments are examined. Varying astrophysical parameters and the dark matter velocity distribution leads to significant changes in acceptance regions and exclusion curves for scenarios in which the tail of the velocity distribution is sampled; this includes 'light dark matter' (mass less than 10 GeV) and 'inelastic dark matter'. The DAMA and CoGeNT collaborations both report an annual modulation in their event rate that they attribute to dark matter. Two analyses of these experiments are performed. In the first, it is shown that these experiments can be compatible with each other and with the constraints from other direct detection experiments. This requires some isospin violation in the couplings of dark matter to protons and neutrons and a small inelastic splitting to boost the modulation fraction. The second analysis provides a comparison of the modulation signals free from all astrophysical parameters, under the assumption that dark matter scatters elastically. Again it is found that some isospin violation and a boosted modulation fraction is required in order that DAMA and CoGeNT are consistent with all experiments. A boosted modulation fraction may arise from a velocity distribution different from the Maxwell-Boltzmann distribution, which is usually assumed. Finally, a supersymmetric theory in which the dark matter candidate is a mixture of left- and right-handed sneutrino is considered. This theory has many novel signatures at colliders, indirect detection and direct detection experiments.

Keywords: supersymmetry
dark matter
Advisor: March-Russell, J
Cassius Dio, human nature and the late Roman Republic

This thesis builds on recent scholarship on Dio’s φύσις model to argue that Dio’s view of the fall of the Republic can be explained in terms of his interest in the relationship between human nature and political constitution. Chapter One examines Dio’s thinking on Classical debates surrounding the issue of φύσις and is dedicated to a detailed discussion of the terms that are important to Dio’s understanding of Republican political life. The second chapter examines the relationship between φύσις and Roman theories of moral decline in the late Republic. Chapter Three examines the influence of Thucydides on Dio. Chapter Four examines Dio’s reliance on Classical theories of democracy and monarchy. These four chapters, grouped into two sections, show how he explains the downfall of the Republic in the face of human ambition. Section Three will be the first of two case studies, exploring the life of Cicero, one of the main protagonists in Dio’s history of the late Republic. In Chapter Five, I examine Dio’s account of Cicero’s career up to the civil war between Pompey and Caesar. Chapter Six explores Cicero’s role in politics in the immediate aftermath of Caesar’s death, first examining the amnesty speech and then the debate between Cicero and Calenus. Chapter Seven examines the dialogue between Cicero and Philiscus, found in Book 38. In Section Four is my other case study, Caesar. Chapter Eight discusses Caesar as a Republican politician. In Chapter Nine, I examine Dio’s version of the mutiny at Vesontio and Caesar’s speech. Chapter Ten examines Dio’s portrayal of Caesar after he becomes dictator and the speech he delivers to the senate. The Epilogue ties together the main conclusions of the thesis and examines how the ideas explored by Dio in his explanation of the fall of the Republic are resolved in his portrait of the reign of Augustus.

Keywords: Roman History
Cassius Dio
Roman Republic
Advisor: Pelling, C
Clark, A
Foraging behaviour and habitat use in the European starling, Sturnus vulgaris, in an agricultural environment

Recent changes in agricultural practice have reduced the diversity of habitats for a number of bird species, including the European Starling Sturnus vulgaris. I investigated the distribution of a starling population on farmland, and related this distribution to the availability of suitable habitats by studying the foraging behaviour of individual birds.
I observed a preference of the overwintering flock for established pasture fields, particularly those which were closer to the central roost, which had shorter grass and which provided feeding areas further from hedges. I also demonstrated the role of leatherjacket Tipula paludosa availabilities in influencing the starlings' choice of feeding site. These prey were shown experimentally to be preferred over earthworms Lumbricus spp. which were the other main type of invertebrate prey available. I was unable to detect any systematic temporal pattern of habitat use which could have been linked to an appropriate theoretical framework (e.g. Ideal Free Distribution).
I investigated the impact of starling foraging on prey availability by observing the behaviour of captive starlings allowed to forage in small enclosures. These experiments indicated that, at the level of foraging pressure expected in natural flocks, there was no significant resource depression during a single flock feeding visit to any one site. Furthermore I proposed that the extent of resource depression during the winter was insufficient to cause a shift in the birds' choice of foraging habitat over this period.
The apparent lack of effects of resource depression raised the question of why starlings did not feed in the most preferred fields all the time. Further enclosure experiments investigated how an individual's foraging success might be affected by feeding with conspecifics. I found no evidence for enhancement or depression of foraging success as a result of feeding where another bird had just previously foraged, and little evidence for an effect of feeding in the presence of two other birds, despite changes in vigilance and time spent fighting. A possibly greater heterogeneity of these effects when in the natural flock situation was considered in relation to the observed flock departures. These and other effects (e.g. sampling the environment) were discussed as possible causes for the observed flock movements between fields.
A final enclosure experiment investigated the impact of starling foraging on prey availability during the breeding season and demonstrated significant resource depression in a preferred field over the chick-feeding period. I then discussed starling foraging and the availability of suitable habitats in relation to the documented population decline of this species.

Advisor: Krebs, J
Reformed epistemology and naturalistic explanations of religious belief: an inquiry into the epistemological implications of the cognitive science of religion

Reformed Epistemology is an influential view in contemporary philosophy of religion, according to which theistic beliefs that are the product of our native, non-inferential cognitive faculties often constitute knowledge if God exists. My aim in this thesis is to ascertain whether Reformed Epistemology is viable in light of contemporary scientific explanations of the mechanisms of religious belief- formation, especially the Cognitive Science of Religion (CSR). I argue for a qualified “yes.” To begin with, I attempt to carefully reconstruct and scrutinise some currently popular “debunking arguments” from CSR’s findings, which aim to show that non-inferential religious beliefs are not knowledge, even if true, given the causal origins that CSR ascribes to them. I try to show that in various ways these arguments fail. Subsequently, I attempt to find a better such argument. The strongest debunking argument, I contend, is one that focuses upon the diverse and mutually inconsistent outputs of the religious belief-producing mechanisms described by CSR. However, I go on to argue that even supposing that this argument succeeds in showing that religious beliefs that are partly the product of contingent cultural influences are not knowledge even if true, there remains a body of what I term “core propositions”—propositions concerning the existence of some kind of personal, supernatural creator and moral lawgiver, in which humans are naturally disposed to believe regardless of their particular cultural setting— that can be known if God exists. Finally, I try to show that merely having this core supernaturalistic knowledge would provide someone with the cognitive contact with God that is sufficient for having a personal relationship with God (if God exists), even if only de re relationship. I argue, moreover, that God would have positively good reasons for creating a world in which human beliefs about life’s most important matters, including religious matters, are significantly dependent upon testimony and hence subject to the ebbs and flows of cultural tides.

Keywords: Etiology of Belief
Knowledge
Reformed Epistemology
Cognitive Science of Religion
Rationality
Advisor: Leftow, B
Sulfonamide supported catalysts for the ring opening polymerisation of cyclic esters

This Thesis describes the synthesis and characterisation of sulfonamide supported titanium, zirconium and aluminium complexes and their use as ring opening polymerisation catalysts for ε-caprolactone and rac-lactide.
Chapter 1 introduces polyester use, development and characterisation in general. Metal catalysed ring opening polymerisation of cyclic esters is considered in a literature review of the field. Titanium, zirconium and aluminium complexes supported by polydentate sulfonamide ligands are also discussed.
Chapter 2 describes the synthesis and characterisation of new sulfonamide supported titanium amide, isopropoxide and zirconium isopropoxide complexes. Their application as catalysts for the ring opening polymerisation of ε-caprolactone and rac-lactide is discussed and compared with known zirconium isopropoxide complexes supported by bis(phenolate) amine ligands.
Chapter 3 describes the synthesis and characterisation of Cs symmetric titanium amide and alkoxide complexes supported by dianionic, tri- and tetradentate sulfonamide ligands. Zirconium alkyl and amide complexes supported by C3- symmetric trianionic ‘tren’ type ligands bearing three different sulfonamide groups are also presented. The application of these complexes for the ring opening polymerisation of ε-caprolactone and rac-lactide is described and compared with the complexes presented in Chapter 2.
Chapter 4 provides an overview of the synthesis and characterisation of aluminium alkoxide and alkyl complexes supported by dianionic, tri- and tetradentate sulfonamide ligands. Solution state behaviour and solid state structures are presented and discussed. An assessment of these complexes for the ring opening polymerisation of rac-lactide is presented.
Chapter 5 presents full experimental procedures and characterisation data for the new complexes reported. CD Appendix contains .cif files for all new crystallographically characterised complexes described, and additional polymerisation graphs.

Keywords: organometalics
caprolactone
titanium
biodegradeable
group 4
polymerisation
plastic
catalysis
sulfonamide
zirconium
aluminium
ring opening polymerisation
hafnium
lactide
cyclic esters
inorganic chemistry
Advisor: Mountford, P
Cell stress response and hypoxia in breast cancer

During severe hypoxia (<0.01% oxygen) the protein folding machinery becomes dysfunctional, resulting in the accumulation of unfolded proteins with consequent endoplasmic reticulum (ER) stress and activation of the unfolded protein response (UPR) and autophagy, a process involved in the physiological turnover of cytoplasmic components. The link between the UPR and autophagy is not clearly defined. The aim of this thesis is to investigate the role of the induction of UPR under severe hypoxia in tumour survival and resistance to therapy. The results of this research suggest that the activating transcription factor 4 (ATF4), a component of the PKR-like ER kinase (PERK) pathway, fundamental in the UPR, is required for the ER-stress induced upregulation of autophagy. Mechanisms other than hypoxia for UPR induction were investigated, using the proteasome inhibitor bortezomib (BZ). BZ treatment increased ATF4 protein levels in MCF7 cells, even transfected with short-interference RNA (siRNA) against the classical UPR activator PERK, suggesting that the proteasomal stabilization is likely the main mechanism for ATF4 protein accumulation. The induction of autophagy by BZ is dependent upon the upregulation of the microtubule-associated protein 1 light chain 3B (LC3B), an autophagy marker, by ATF4 and acts as a survival mechanism. Hypoxia, UPR and autophagy markers (such as Pimonidazole, carbonic anhydrases IX (CAIX), C/EBP homologous protein (CHOP) and LC3B) were evaluated by immunohistochemical approach in spheroids, xenografts models and breast cancer samples. CHOP immunohistochemical staining was performed in breast cancer sections from a series of patients. CHOP was expressed in cells surrounding necrotic areas. No correlation were found with clinical outcome and further studies are needed.

Keywords: autophagy
hypoxia
ATF4
breast cancer
Advisor: Harris, A
The role of NLRs in induction and resolution of intestinal inflammation

Innate immune activation is thought to play a central role in IBD pathogenesis because genetic polymorphisms in NOD2 and NLRP3, cytosolic innate immune receptors belonging to the NLR family, have been associated with IBD susceptibility. However, the mechanisms through which NLR mutations predispose to IBD remain unclear. The aim of this project was to dissect the functional roles of different NLRs in intestinal inflammation. Using the well-established DSS-induced colitis model as well as experimental models of IBD based on infection with Helicobacter hepaticus, we found that Nod2 expression was significantly increased at the peak of intestinal inflammation, and remained elevated throughout the resolution process. This observation suggests a possible role for Nod2 in the resolution of inflammation. Conversely, upon infection with the acute intestinal pathogen Citrobacter rodentium, Nlrp3-/- mice suffered from increased bacterial colonization as early as 3 days post infection, resulting in exacerbated intestinal inflammation and severe weight loss. Analysis of irradiation bone marrow chimeras showed that the protection required Nlrp3 activation in the non-haematopoietic compartment. Furthermore, this protective mechanism was independent of the inflammasome-associated cytokines IL-1β or IL-18. Therefore, this study implicates Nlrp3 activation in intestinal tissue cells as having a crucial role in controlling pathogenic bacterial colonization, providing a potential mechanism by which NLRP3 polymorphisms could lead to increased susceptibility to IBD.

Keywords: intestinal infections
immunology
inflammatory bowel diseases
colitis
Helicobacter
Citrobacter
Advisor: Maloy, K
Mycoplasma pneumoniae and Bordetella pertussis in patients with persistent cough in primary care

Background Persistent cough following an acute respiratory tract infection is a challenging and frequently encountered problem in primary care. Mycoplasma pneumoniae (M. pneumoniae) and Bordetella pertussis (pertussis) particularly predispose patients to persistent cough. Whilst the incidence of M. pneumoniae is highest in children, pertussis may also occur in adults.
Method Four studies were conducted for this thesis. First, a systematic review to assess the diagnostic accuracy of symptoms and signs in the clinical recognition of M. pneumoniae. Second, a retrospective analysis of a cohort of children with persistent cough to assess the prognostic value of diagnosing M. pneumoniae. Third, a prospective cohort study to estimate the prevalence of M. pneumoniae and pertussis in children with persistent cough following recent changes in vaccination policy. Fourth, a double-blind randomised placebo-controlled trial to determine the effectiveness of montelukast in the treatment of persistent cough and pertussis-induced cough in adults.
Results M. pneumoniae and pertussis can each be found in one-sixth of children who present in primary care with persistent cough. Although coverage with the preschool pertussis booster vaccine is high, its efficacy wanes rapidly, with the likelihood of pertussis increasing by 30% per year after vaccination. Montelukast is not an effective treatment for persistent cough, but may be an effective treatment for pertussis-induced cough.
Median duration of cough in children with M. pneumoniae is only one-third of that in children with pertussis (39 days versus 118 days). However, the diagnostic accuracy of symptoms and signs in the clinical recognition of M. pneumoniae is limited. Since M. pneumoniae occurs in cyclical epidemics, clinicians should consider current prevalence of M. pneumoniae when making a clinical diagnosis.
Conclusions Diagnosing M. pneumoniae and pertussis can help clinicians give patients an explanation for their cough and inform them about its likely prognosis. At the moment, clinicians should adopt a conservative approach to managing postinfectious persistent cough. A further trial is needed to assess the efficacy of montelukast for the treatment of pertussis-induced cough.

Keywords: Cough
Mycoplasma pneumoniae
Whooping cough
Respiratory Tract Infection
Advisor: Harnden, A
Mant, D
The politics of sectarianism in the Gulf

This thesis explores Shi’a-Sunni relations in Gulf politics during a period of regional upheaval, starting with the 2003 invasion of Iraq through the Arab revolts of early 2011. It seeks to understand the conditions under which sectarian distinctions become a prominent feature of the Gulf political landscape, focusing on the three Gulf countries that have been affected most by sectarian tensions: Bahrain, Saudi Arabia, and Kuwait.
The study analyzes the contagion effect of the civil war in Iraq, the 2006 war in Lebanon, and the Arab Spring on local sectarian dynamics in the three states. Specifically, it explores the role of domestic institutions—parliaments and other quasi-democratic structures, the media, and clerical establishments—in tempering or exacerbating sectarianism. It finds that the maturity and strength of participatory institutions in each state played a determinant role in the level of sectarianism resulting from dramatic shifts in the regional environment since the 2003 invasion of Iraq.
I conclude, therefore, that the real roots of the so-called “rise of the Shi’a” phenomena lie in the domestic political context of each state, rather than in the regional policies of Iran or the contagion effect of events in Iraq or Lebanon. Although the Gulf Shi’a took a degree of inspiration from the actions of their co-religionists in Iraq, Iran and Lebanon, they ultimately strove for greater rights in a non-sectarian, nationalist framework. The rise of sectarianism in the Gulf has been largely the product of excessive alarm by entrenched Sunni elites or the result of calculated attempts by regimes to discredit Shi’a political actors by portraying them as proxies for Iran, Iraq, or the Lebanese Hizballah. What is qualitatively different about the post-2003 period is not the level of mobilization by the Shi’a, but rather the intensity of threat perception by Gulf regimes and Sunni Islamists.

Keywords: Kuwait
Saudi Arabia
Lebanon War (2006)
Iraq War
Arab Spring
Bahrain
sectarianism
Shiites
Advisor: Robins, P