VictorJuiz/thesis huggingface dataset:
Emmanuel Lévinas' Barbarisms: Adventures of Eastern Talmudic Counter-Narratives Heterodoxly Encountering the South

This dissertation examines the scope and limitations of the re-appropriation of the term barbarism by modern Jewish intellectuals in conversation with Third World social movements. Emmanuel Lévinas is my paradigmatic example of this re-appropriation, as his Talmudic interpretations illuminate this process, and his work is located on the axis of the encounter between Jewish and decolonial thinking. I contend that Lévinas follows a classic line of modern European interpreters who expressed their discomfort with the description of the Jewish people as barbaric. While this discomfort can be traced within this orthodox interpretation of Lévinas, I argue that his particular solution for the problem can only be explained by a more heterodox exploration. Lévinas’ positive re-appropriation of the term is part of contextual conversations that he sustained with other peoples characterized as barbarians (i.e. Third World decolonial theorists). While this re-appropriation was originally conceived in order to establish an East-East revolutionary conversation between Eastern European rabbinical interpreters and other radical Eastern projects (i.e. Maghrebi Marxism) it became an East-South decolonial conversation between Jewish and Afro-Caribbean/Latino-American intellectuals. This conversation, however, ultimately challenges the apologetic Jewish re-appropriation of exteriority in the concert of multiple barbarians. I explore the limitations of Jewish thought to engage with this community and cross from an apologetic to a critical barbarism. This dissertation, in conclusion, seeks to make an original contribution in the interrelation between Jewish and post-colonial studies. I aim to do so by first, demonstrating that the Jewish return to classical sources is historically and conceptually a decolonial counter-narrative that was influenced by (and in turn influenced) Third World discourses; second, explaining the reasons and consequences of the persistence of Jewish imagery and influences in Third World decolonial theory; third, exploring the limits of Jewish thinking and the benefits of the expansion of Jewish apologetical dialogues into barbaric critical conversations. And finally, challenging most contemporary scholarship in modern Jewish philosophy, which holds that Jewish thought and the modern re-reading of its sources can only be understood in the context of Western consciousness.

Keywords: Jewish Studies
Post-Colonial Theory
Lévinas, Emmanuel
Dussel, Enrique
Jewish Philosophy
Racial Theory
Marxism
Critical Theory
Modern Thought and Culture
Third World Social Movements
Continental Philosophy
Sociology of Knowledge
Modern Rabbinics
Advisor: Gibbs, Robert B.
The Afterlife of Shakespeare's Plays: A Study of Cross-cultural Adaptations into Opera and Film

This study considers the ways in which Shakespeare’s plays have been adapted in cross-cultural contexts from the nineteenth century to the present, specifically in Europe and India, through the media of opera and film. I bring into dialogue reception theory, adaptation studies, Shakespeare scholarship, musicology, film studies, and postcolonial theory in order to examine the mechanisms of Shakespeare’s reception in these two culturally diverse regions of the globe, and argue that there are significant parallels between European and Indian adaptations of Shakespeare. Despite the different cultural and political histories of the two regions, Shakespeare’s plays reached out to local audiences only when they were modified in order to make them relevant to the cultural and ideological concerns of the new audiences that were far removed from Shakespeare’s own. Moving away from understanding Shakespeare’s reception either in terms of the dramatist’s “universal appeal” or in terms of colonial instrumentality, as has usually been the case, I argue that such predetermined critical paradigms take away from what in Shakespeare various cultures have found truly valuable, truly affective. Moreover, I argue that the degree of transculturation, both with European and Indian adaptations, is greater when Shakespeare is adapted in media that involves performance, than when he is adapted in a purely verbal medium, such as translations. This process of indigenization through performance, one that I have termed “performative transculturation,” has opened up fresh avenues of cross-cultural exchange over the ages. The works I examine in detail are Ambroise Thomas’ opera Hamlet, Giuseppe Verdi’s opera Otello, Ishwarchandra Vidyasagar’s Bhrantibilash, a prose adaptation of The Comedy of Errors, and Vishal Bhardwaj’s films Maqbool and Omkara, based on Macbeth and Othello respectively.

Keywords: Shakespeare
Adaptations
Opera
Film
Europe
India
Cross-Cultural
Postcolonial
Music
Renaissance
Advisor: Hutcheon, Linda
Role of Nestin in Mouse Development

Although nestin has served as a marker of neural stem/progenitor cells for close to twenty years, its function is still poorly understood. During development, this intermediate filament protein is expressed in many different progenitors including those of the central nervous system, heart, skeletal muscle and kidney. The adult expression of nestin is mainly restricted to the subependymal zone and dentate gyrus of the brain, the neuromuscular junction and renal podocytes. I have used two approaches of gain of function and loss of function to elucidate the role of nestin in vivo. Although I was able to generate transgenic lines in which the transgene was ubiquitously expressed at the RNA level, over-expression of nestin at the protein level was not achieved possibly due to post transcriptional regulation of this gene. My data from loss of function approach indicates that nestin-deficient mice have impaired coordination. Balance and muscle strength are not affected and there are no apparent anatomical defects. I found that nestin deficiency is compatible with normal development of the central nervous system but results in abnormal clustering of acetylcholine receptors in the neuromuscular junctions, similar to the phenotype described for deficiency of cyclin-dependent kinase 5 (Cdk5) a candidate downstream effector of nestin. In renal podocytes, where both nestin and Cdk5 are normally expressed, we found reduced branching and abnormally contoured podocyte processes. To further connect the phenotype of nestin deficiency to Cdk5, I demonstrated that nestin deficiency can rescue maintenance of acetylcholine receptor clusters in the absence of agrin, similar to Cdk5/agrin double knockouts, indicating that the observed nestin deficiency phenotypes are the consequence of aberrant Cdk5 activity.

Keywords: Nestin
Neuromuscular junction
Advisor: Nagy, Andras
The Normative Implications of Personal Identity Theory

This dissertation investigates the relationship between personal identity theory and normative ethics. There are a surprising number of contradictory arguments about the relevance of personal identity criteria for ethics and political philosophy. For example, writers like David Gauthier, Thomas Nagel and John Rawls argue that utilitarianism disregards the separateness, or non-identity, of persons. Derek Parfit claims the opposite. According to him, utilitarians respect the separateness of persons while also respecting the disintegration within lives. Also, Henry Sidgwick was under the impression that the separateness of persons supports egoism and disregard for the other-regarding demands of morality. David Brink claims the opposite. According to him, the resulting form of egoism would be nearly indistinguishable from altruism and therefore not at odds with the other-regarding demands of morality. Finally, both Rawls and Nozick argue that the separateness of persons speaks in favour of their own deontological view—despite the fact that their views are fundamentally opposed. Rawls hopes to gain support for his contractually derived principles of justice, while Nozick believes he can generate support for his deontological side constraints. This situation is rather surprising and in need of an explanation. Finally, there have also been skeptical arguments about the force of such appeals, such as Rawls’s claims that personal identity theory and ethics are independent, and his claim that personal identity criteria are inherently normative. This dissertation looks at these controversies in detail and comes to the conclusion that the force of appeals to personal identity is considerably more fine-grained and more complex than has been presumed.

Keywords: personal identity
normative ethics
Advisor: Hurka, Thomas
The Mudang: Gendered Discourses on Shamanism in Colonial Korea

This dissertation examines the discursive production of mudang, also known as shamans, during the late Chosŏn Dynasty (eighteenth to nineteenth-centuries) and during the Japanese colonial period in Korea (1910-1945). The many discursive sites on mudang articulated various types of difference, often based on gender and urban/rural divides. This dissertation explores four bodies of work: eighteenth to nineteenth-century neo-Confucian reformist essays, late nineteenth-century western surveys of Korea, early twentieth-century newspapers and journals, and early ethnographic studies. The mudang was used throughout this period to reinforce gendered distinctions, prescribe spatial hierarchies, and promote capitalist modernity. In particular, institutional developments in shamanism studies under colonial rule, coupled with an expanded print media critique against mudang, signalled the needs and desires to pronounce a distinct indigenous identity under foreign rule. Chapter one traces three pre-colonial discursive developments, Russian research on Siberian shamanism under Catherine the Great, neo-Confucian writings on "mudang," and Claude Charles Dallet’s late nineteenth-century survey of Korean indigenous practices. Chapter Two examines the last decade of the nineteenth-century, studying the simultaneous emergence of Isabella Bird Bishop’s expanded discussion on Korean shamanism alongside early Korean newspapers’ social criticisms of mudang. Chapter Three looks at Korean newspapers and journals as the source and product of an urban discourse from 1920-1940. Chapter Four examines the same print media to consider why mudang were contrasted from women as ethical household consumers and scientific homemakers. Chapter Five looks at Ch’oe Nam-sŏn and Yi Nŭng-hwa’s 1927 treatises on Korean shamanism as a celebration of ethnic identity which became a form of intervention in an environment where Korean shamanism was used to justify colonial rule.

Keywords: modern korean history
gender and religion
shamanism and indigenous studies
urban studies
post-colonial studies
Advisor: Schmid, Andre
Poole, Janet
Song, Jesook
Derivation and Characterization of Bone Cells from Human Umbilical Cord Blood and Harakiri Deficient Mice

There is a growing need for bone cells to be used in the generation and repair of bone tissues that have become destroyed as a result of disease (e.g. osteoporosis), injuries and genetic deficiencies. Human umbilical cord blood has been a source of cells that is being investigated for its ability to generate cells for repair of various tissues including bone, which is the focus of this investigation. Similarly cord blood can also be used as a source of progenitors for osteoclasts that might be used for management of other diseases of bone characterized by defects in these cells (e.g. osteopetrosis). Moreover, there are few reliable in vitro models for human osteoclasts and so the ability to develop a cell model for human osteoclasts will also permit more meaningful studies on regulation of these cells than possible in the past. One of the setbacks suffered by researchers in designing therapeutic uses for stem cells is that in laboratory animals tumours can arise from these transplanted and pleuripotential cells. This suggests that stem cells might also have a dysregulated apoptosis pathway, which is critically important to understand before the safe use of stem cells can be assured. In order to increase our understanding of apoptosis in bone cells in particular, studies were done to try to understand the role of harakiri, a pro-apoptotic gene, in the development of osteoblasts and osteoclasts. Therefore, this series of study had two main foci; the development of human bone cells, particularly osteoclasts and osteoblasts, from human umbilical cord blood, and to understand further the mechanisms regulating apoptosis in bone cells. This study showed that osteoblasts could not be derived easily from human cord blood cells while it was possible to generate fully functional osteoclasts, which demonstrated unique properties. Studies done on harakiri deficient mice showed that absence of this gene caused an increase in osteoblast formation and a decrease in osteoclast formation. These findings can be exploited when considering the development of pharmacological agents that might be used in the future to modulate osteoclast cell development, function, and apoptosis.

Keywords: bone cells
harakiri
osteoblast
osteoclast
Advisor: Casper, Robert
A Novel gene overexpression plasmid library and its application in mapping genetic networks by systematic dosage suppression

Increasing gene dosage provides a powerful means of probing gene function, as it tends to cause a gain-of-function effect due to increased gene activity. In the budding yeast, Saccharomyces cerevisiae, systematic gene overexpression studies have shown that in wild-type cells, overexpression of a small subset of genes results in an overt phenotype. However, examining the effects of gene overexpression in sensitized cells containing mutations in known genes is a powerful means for identifying functionally relevant genetic interactions. When a query mutant phenotype is rescued by gene overexpression, the genetic interaction is termed dosage suppression. I comprehensively investigated dosage suppression genetic interactions in yeast using three approaches. First, using one of two novel plasmid libraries cloned by two colleagues and myself, I systematically performed dosage suppression screens and identified over 130 novel dosage suppression genetic interactions for more than 25 essential yeast genes. The plasmid libraries, called the molecular barcoded yeast ORF (MoBY-ORF) 1.0 and 2.0, are designed to streamline dosage analysis by being compatible with high-throughput genomics technologies that can monitor plasmid representation, including barcode microarrays and next-generation sequencing methods. Second, I describe a detailed analysis of the novel dosage suppression interactions, as well as of literature-curated interactions, and show that the gene pairs exhibiting dosage suppression are often functionally related and can overlap with physical as well as negative genetic interactions. Third, I performed a systematic categorization of dosage suppression genetic interactions in yeast and show that the majority of the dosage suppression interactions can be assigned to one of four general mechanistic classifications. With this comprehensive analysis, I conclude that systematically identifying dosage suppression genetic interactions will allow for their integration into other genetic and physical interaction networks and should provide new insight into the global wiring diagram of the cell.

Keywords: genetics
genomics
budding yeast
Advisor: Boone, Charles
Economic Evaluation of Percutaneous Coronary Intervention in Stable Coronary Artery Disease: Studies in Utilities and Decision Modeling

The initial treatment options for patients with stable coronary artery disease include optimal medical therapy alone, or coronary revascularization with optimal medical therapy. The most common revascularization modality is percutaneous coronary intervention (PCI) with either bare metal stents (BMS) or drug-eluting stents (DES). PCI is believed to reduce recurrent angina and thereby decrease the need for additional procedures compared to optimal medical therapy alone. It remains unclear if these benefits are sufficient to offset the increased costs and small increase in adverse events associated with PCI. The objectives of this thesis were to determine the degree of angina relief afforded by PCI and develop a tool to provide contemporary estimates of the impact of angina on quality of life. In addition, we sought to develop a comprehensive state-transition model, calibrated to real world costs and outcomes to compare the cost-effectiveness of initial medical therapy versus PCI with either BMS or DES in patients with stable coronary artery disease. ii We performed a systematic search and meta-analysis of the published literature. Although PCI was associated with an overall benefit on angina relief (odds ratio [OR] 1.69; 95% Confidence Interval [CI] 1.24-2.30), this benefit was largely attenuated in contemporary studies (OR 1.13; 95% CI 0.76-1.68). Our meta-regression analysis suggests that this observation was related to greater use of evidence-based medications in more recent trials. Using simple linear regression, we were able to create a mapping tool that could accurately estimate utility weights from data on the Seattle Angina Question, the most common descriptive quality of life instrument used in the cardiovascular literature. In our economic evaluation, we found that an initial strategy of PCI with a BMS was cost- effective compared to medical therapy, with an incremental cost-effectiveness ratio (ICER) of $13,271 per quality adjusted life year gained. In contrast, DES had a greater cost and lower survival than BMS and was therefore a dominated strategy.

Keywords: coronary artery disease
stable angina
economic evaluation
cost-effectivenesss
utilities
quality of life
medical therapy
angioplasty
percutaneous coronary intervention
meta-analysis
mapping algorithm
bayesian
Advisor: Krahn, Murray
The Good Doctor in Medical Education 1910-2010: A Critical Discourse Analysis

Ideas of what constitutes a good doctor underlie decisions about medical student selection, as well as curriculum design and the structure of medical education at both undergraduate and postgraduate levels of training. Factors at play include knowledge paradigms (what does a good doctor need to know), identity paradigms (who can become a good doctor) and notions about the relationship of doctors to society (the social responsibility or social accountability of the good doctor). As with any social phenomenon, constructs of the good doctor are historically derived and socially negotiated. Ideas about the good doctor tend to be considered as ‘truths’ in any era, with little attention to or understanding of the assumptions that underpin any particular formulation. In this thesis, I explore and dissect the dominant constructs of the good doctor in North American medical education between 1910 and 2010. Drawing upon Foucauldian critical discourse analysis, I focus particular attention on discursive shifts in the conception of the good doctor over the past century. This analysis reveals a series of discursive shifts in the framing of the good doctor in medical education between 1910-2010. Abraham Flexner promoted the construct of the good doctor as a scientist physician who was also a man of character. In the post-Flexnerian transformation of medical education, science became curricular content while the discourse of character remained. In the late 1950s a sudden discursive shift occurred, from the character of the good doctor to characteristics. With this shift, the student was dissected as an object of study. Further discursive shifts incorporated discourses of performance and production into constructs of the good doctor as roles-competent. This research explores the implications and consequences of these various discursive framings of the good doctor.

Keywords: medical education
critical discourse analysis
Advisor: Austin, Zubin
Figures de la « patience » dans la modernité : la recherche proustienne entre l'errance de Bouvard et Pécuchet et le parti pris pongien

Cette étude porte sur la représentation de la « patience » – considérée comme un mode d’être dans le temps et face à l’Autre à la fois actif et passif – dans quelques œuvres modernes, notamment les écrits philosophiques de Friedrich Nietzsche, les romans Bouvard et Pécuchet et La tentation de saint Antoine de Gustave Flaubert, À la recherche du temps perdu de Marcel Proust et la poésie de Francis Ponge. Dans le premier chapitre, nous nous référons à la pensée de Nietzsche pour bien décrire le contexte moderne qui fait que la vertu de la patience est aussi pertinente à la fin du XIXe siècle et pendant le XXe siècle qu’elle ne l’était pour des penseurs de l’Antiquité gréco-romaine comme Épicure et Sénèque. Dans des œuvres comme La généalogie de la morale et Par-delà bien et mal, Nietzsche montre que ce qu’on considère comme la vertu de la patience se réduit souvent à une simple incapacité d’agir et que les temps modernes exigent un autre type de vertu, une patience renouvelée et affirmative. Dans le deuxième chapitre, nous analysons les thèmes de l’accompagnement et du dévouement dans deux romans flaubertiens afin de déterminer dans quelle mesure il est nécessaire de se retirer du monde et de ses rythmes pour pouvoir se consacrer à quelque chose qui transcende l’individu et ses désirs particuliers. Nous continuons cette réflexion dans le chapitre sur le roman proustien, où l’on peut suivre la trajectoire d’un héros-narrateur impatient d’être aimé et de remplir sa vocation en devenant écrivain. Notre examen de différentes formes de la patience est complétée par une critique du rapport problématique du poète (Ponge) et des objets de ses poèmes, en particulier les animaux qu’il sacrifie au nom de son art. Un schéma fondamental se dessine à travers toutes ces œuvres et les figures de la patience qu’elles véhiculent : le sujet humain, désireux de se rapprocher de l’Autre, sait que, pour ce faire, il faut le laisser être, mais il a aussi besoin de s’affirmer soi-même, d’où une certaine aporie. La patience se révèle comme une réponse possible à ce problème.

Keywords: patience
modernité
figure
ascétisme
littérature et philosophie
Ponge
Proust
Flaubert
Advisor: Cozea, Angela