VictorJuiz/thesis huggingface dataset:
Teaching English as a Foreign Languate and Using English as a Medium of Instruction in Egypt: Teachers’ Perceptions of Teaching Approaches and Sources of Change

With the internationalization of English there is a growing demand for high quality English language education around the globe, particularly in non-English speaking countries. Consequently, there is an increasing demand worldwide for competent English teachers and more effective approaches to teaching and teacher professional development. In Egypt, in a context of educational reform where communicative language teaching approaches have been adopted as a way to improve teaching, this study explores how teachers perceive and respond to this call for change in instructional practices. It examines the professional development experiences of a group of English as a foreign language (EFL) and English-medium subject (EMS) teachers working in the private and public basic educational sectors in Cairo, Egypt. The research questions focus on teachers’ perceptions of change and improvement occurring in their teaching practices, their beliefs on the sources of change available to them, and the perspectives of school principals and professional development providers on teachers’ change prospects. In this study, a multi-method approach was applied, with a teacher survey administered to 174 teachers; in-depth, semi-structured interviews with 36 teachers, 15 principals, and 8 professional development (PD) providers; field observation; and examination of relevant documents and artifacts. The analysis of data is informed by sociocultural theory perspectives (Vygotsky, 1978). The findings indicate that (1) teachers perceive great change in their practices, though their conceptions and implementation of communicative approaches are context-bound, (2) teaching is influenced by various professional learning opportunities, and (3) change or lack thereof results from teachers’ adaptability to their local contextual demands through a process of resistance, resilience, or maintaining the status quo. The findings highlight the centrality of teachers in change processes.They suggest that change results from a process of interaction between teachers and other individuals within their community, and that the nature of change as experienced by the participants is shaped by a multitude of contextual factors. The implications of the study include the need to replace the technical conception of professional development with a more ecological orientation, to establish professional learning communities among teachers and within schools, and to establish a coherent framework for change initiatives.

Keywords: teacher education
professional development
EFL teaching
Egypt
teaching approaches
sources of change
instructional change
private education sector
public education sector
Advisor: Gagne, Antoinette
Making Trade-offs among Security and Other Requirements during System Design

Employing a design solution can satisfy some requirements while having negative side-effects on some other software requirements and project objectives. Ultimately, selecting a design solution among multiple options involves making trade-offs among competing requirements. These trade-offs, especially at the early stages of software development, are often hard to identify or quantify, and can be subjective. Security is one critical requirement among many, which can cause critical trade-offs and severe costs. Damages from security attacks can be overwhelming and the costs increase every year. The threat of vulnerabilities and their exploitation by potential adversaries calls for careful analysis of security risks and trade-offs that security solutions impose, from the viewpoints of both defenders and attackers. Since software developers and analysts are usually not security experts, detecting potential threats within software systems can be problematic. Even when threats are known, the risk factors, either the probability of a successful attack or the resulting damage of a successful attack, are not always known or numerically measurable. In this situation, selecting proper security solutions can be challenging, when mitigating impacts and side-effects of solutions are often not quantifiable. This thesis addresses such challenges in identifying and making trade-offs among security and other system requirements and stakeholders' goals. This work introduces a framework for identifying and modeling security risks and requirements trade-offs. The central idea in this thesis is analyzing security requirements on the basis of predicting software vulnerabilities, weaknesses or flaws that can be exploited to break into the system. Vulnerabilities and exploitation scenarios are specified within goal-oriented requirements models of the system. This approach enables analysis of vulnerability exploitations and their impacts on the running system. The structure of goal-oriented security requirements models enables tracing the ultimate impacts of the exploitations on high-level goals of stakeholders and design objectives. In order to evaluate the risk of vulnerabilities, this framework intertwines the Common Vulnerability Scoring System (CVSS) with security requirements risk assessment. The proposed framework provides a decision aid method that takes into the account risks, competing requirements, security solutions, their impacts on risks, and their side-effects on other requirements, to aid decision makers to select a solution among alternative security solutions. The proposed decision analysis method helps analysts to make requirements trade-offs systematically, in the absence of quantitative data, or when a mixture of both quantitative and qualitative data are available.

Keywords: Security
Trade-off
Requirements
Software Design
Advisor: Yu, Eric
Utilization of Pulp and Paper Mill Sludge as Filler in Nylon Biocomposite Production

The biological treatment of pulp and paper mills effluents results in the production of waste secondary sludge which is hard and costly to dewater and dispose. Secondary sludge, which is structurally comparable to the municipal sewage sludge, is composed of microbial cells, organic woody materials, and ash. In this work, the use of this waste biosolid as renewable and cost-cutting filler in the composite industry is proposed. Moreover, the effect of enzymatic treatment of the waste biosolid on the final properties of the manufactured biocomposite is studied. The high protein content of the secondary sludge (35 ± 5%) and the surface thermodynamics measured by Inverse Gas chromatography (IGC) led us to choose Nylon 11 as the main polymeric matrix. The biocomposites samples produced by compounding and injection molding of different mixtures of dried secondary sludge and Nylon were tested. The results of mechanical strength tests showed that a 10% sludge content does not lead to any significant deterioration of either tensile or flexural strengths. Therefore, it is concluded that the secondary sludge may be used as filler to reduce the cost while maintaining the mechanical properties of Nylon. Enzymatic modification of the waste biosolid to advance its application from cheapening filler to reinforcing filler has also been proposed in this work. Lipase and laccase utilized for the modification of the sludge in order to reduce the hydrophobicity and increase the molecular weight, respectively. Lipase application did not lead to any significant changes in either tensile or flexural strengths. This is attributed to the rather low content of lipids in the sludge. On the other hand, enzymatic modification of the sludge by laccase which increases the molecular weight of the existing lignins, resulted in significant improvement of the flexural strength of the manufactured biocomposite.

Keywords: biocomposite
waste sludge
Advisor: Sain, Mohini
Preventing Back Injury in Caregivers

Caregivers injure their backs more than workers in any other industry. Efforts to reduce injuries have been on-going for decades with limited results. Mechanical lift devices have been incorporated into clinical practice over the past 30 years to reduce the risk of injury from patient lifting. Yet injury rates remain high. The use of mechanical lifts may be partly to blame. While these devices assist with lifting patients, they also introduce new activities that result in caregivers experiencing unsafe loading on the spine. We measured loads on the lower back during manoeuvres of the two most common lift types (overhead and floor) as well as during sling insertion. A new device called SlingSerterTM was evaluated for use in the clinical environment. We also investigated spine shrinkage as a measurement tool for estimating cumulative load. Caregivers worked alone and in pairs for both lift maneuvering and sling insertion activities. Overhead lift use resulted in much lower loads than floor lift use. We conclude caregivers can safely operate overhead lifts alone, while floor lift use remained unsafe even with two caregivers. Less-experienced caregivers had higher loads than more-experienced counterparts when using floor lifts. There was no corresponding effect of experience with overhead lift use and we found this to be a further benefit of overhead lifts over floor lifts. Most caregivers exceeded the safe limit for spine compression during sling insertion, though a single caregiver was at no higher risk of injury than two caregivers working together. Clinicians who tested SlingSerterTM agreed the device would be useful in clinical practice, particularly with bariatric patients and other special patient populations that are difficult to roll or turn. Finally, we investigated a novel method for estimating cumulative load based on spine shrinkage. There is growing recognition that excess cumulative load may be responsible for back injury. We found the variability in spine shrinkage was too large to estimate cumulative load directly. However, the technique may still be useful for determining the relative importance of the load from different activities to the cumulative total.

Keywords: Back injury
Biomechanics of nursing
Nursing
Patient handling
Safe patient handling
Spine biomechanics
Patient lifting
Mechanical lifts
Overhead lift
Floor lift
Back pain in nurses
Back injury in nurses
Injury prevention
Advisor: Fernie, Geoff
Characterization and Role of Krüppel-like Factor 2 in Models of Pulmonary Hypertension

Pulmonary arterial hypertension (PAH) results from endothelial cell (EC) damage leading to pulmonary vasoconstriction and arteriolar remodeling. Patients with PAH exhibit high pulmonary arterial pressures due to increased pulmonary vascular resistance and die of progressive right-sided heart failure. The pathogenesis of PAH is not completely understood, but involves processes which reflect abnormalities in EC function: an imbalance of vasodilators and constrictors, thrombosis, vascular smooth muscle cell (SMC) hypertrophy and proliferation, and susceptibility to EC apoptosis. Therefore, it is important to investigate possible alterations in the underlying mechanisms that regulate EC structure and function. Krüppel-like factor 2 (KLF2) is a shear-responsive transcription factor, highly expressed in the pulmonary ECs under physiological conditions, and known to maintain EC homeostasis by acting as a master switch for a quiescent profile of EC gene transcription. We hypothesized that Klf2 expression is reduced in models of pulmonary hypertension (PH) and its down-regulation contributes to PH development; conversely, Klf2 overexpression is beneficial, and may represent a novel therapeutic target. The role of KLF2 in PH was characterized in two experimental rat models: the monocrotaline model of severe and lethal PAH, and the chronic hypoxia model of reversible hypoxic PH. In vivo Klf2 expression was manipulated using jetPEI® to enhance or reduce the activity of the KLF2 pathway. Plasmids containing short hairpin Klf2 (shKLF2) or Klf2, or empty plasmids were selectively delivered to the pulmonary microvasculature, and the effect on pulmonary hemodynamics, microvascular structure and function, along with various in vitro functional and molecular assays of EC activity, were assessed. Results suggest that reduced Klf2 expression may be a critical early event in EC activation and initiation of PAH; and, its persistent downregulation may play a role in the transition to a progressive and irreversible process. Data also suggests that an early therapeutic intervention to overexpress Klf2, can prevent the development of PH in both models tested when applied before the “irreversible” microvascular remodeling is present. However, once the full PAH phenotype is established, in particular in the presence advanced arteriolar remodeling, Klf2 gene transfer was unsuccessful in reversing the disease in the MCT model.

Keywords: pulmonary hypertension
endothelium
kreuppel-like factor 2
Advisor: Stewart, Duncan John
Against the Medicalization of Humanity: A Critical Ethnography of a Community Trying to Build a World Free of Sanism and Psychiatric Oppression

We have to stop inventing disorders for every human experience that challenges the status quo… I dream of a world where people can peacefully co-exist… [where] differences are accepted… [and where] I, and everybody else, has a place (Jackie, psychiatric survivor and mad person). The thesis is a critical ethnography of a political community in Toronto, Canada whose members are challenging the theories and interventions of biological psychiatry and developing approaches to understanding and responding to human experience in alternative ways that empower people who are conceived of as “mad”. Based on the emerging ideological and practical differences among participants, a model of the community was developed that includes three main constituencies: the psychiatric survivor constituency, the mad constituency, and the antipsychiatry constituency. This thesis includes descriptive accounts of the philosophical understandings, priorities, goals, actions, and strategies emerging from each of these constituencies; some tensions and conflicts that arise in the community around working across difference; the genuine attempts made by community members to build alliances, the challenges they face, and the notable progress they have made. The thesis grapples with how community members might work towards building a paradigm for solidarity work with others who share a stake in building communities that are free of sanism and psychiatric oppression. The dissertation ends with an exploration of how clinical and counselling psychologists might proceed in their work taking into consideration the experiences and perspectives shared by participants.

Keywords: community organizing
psychology
psychiatric survivor
Advisor: Burstow, Bonnie
Acyl Phosphates: Biomimetic Reagents for Selective Acylation in Water

Acyl groups in biochemical reactions are activated as acyl adenylates; such intermediates are generated by a reaction with ATP. Acyl adenylates are mixed carboxylic-phosphoric anhydrides which are potentially useful as biomimetic reagents for acylation reactions in water. These species have been reported to be unstable and have been isolated without purification. Since the adenylate portion is necessarily complex because it originates from ATP, we reasoned that using a simple alkyl group in place of adenosine might allow the biomimetic process to proceed without the difficulties reported. Our laboratory has developed routes towards such acyl phosphate alkyl monoesters and we have used them for several applications. Such materials react rapidly and selectively with amines in order to produce amides. While reactions utilizing lanthanide ions allow for the selective monoacylation of diols through bis-dentate chelates of the lanthanide. However, the efficiency of diol acylation is limited due to significant hydrolysis of the phosphate reagent and the requirement of a stoichiometric amount of the lanthanide ion. Therefore, three distinct approaches towards improving the efficiency of lanthanide promoted acylation were investigated: addition of an inert co-solvent in an attempt to reduce hydrolysis, eliminating the stoichiometric requirement of the lanthanide by addition of MgII, and the development of immobilized lanthanides as catalysts for acylation. Finally, aminoacyl phosphates are biomimetically activated amino acids and in principle should function as peptide synthesis reagents. The stability and solubility of the activated materials in water presents an opportunity to perform aqueous peptide coupling; such a process is limited by the fact that common peptide coupling agents are either insoluble or unstable in water. Therefore, we investigated the reactions of aminoacyl phosphates with amino acid esters. We find that peptides form readily in buffered solutions, establishing a basis for a general protocol for aqueous amino acid coupling and could be adapted for applications such as solid phase peptide synthesis.

Keywords: biomimetic
green chemistry
peptide synthesis
acyl phosphates
lanthanides
Advisor: Kluger, Ronald
Impact of Chemotherapy Dosing Schedule on Ovarian Cancer Tumor Responsiveness

In Canada, ovarian cancer kills about 67% of diagnosed patients, largely due to difficulties in early diagnosis. Current treatment consists of debulking surgery and intermittent chemotherapy every three weeks. This approach leads to insufficient drug concentrations at disease sites, and long treatment-free intervals cause accelerated tumor proliferation and drug resistance, resulting in a 5-year survival rate of only 25-35%. Drug resistance development is the ultimate cause of the majority of patient deaths. Improvements yielding more effective treatment are fundamental for successful management of this disease. This thesis investigated a continuous chemotherapy strategy devoid of treatment-free intervals for ovarian cancer treatment. A biocompatible, biodegradable polymer-lipid injectable formulation PoLigel, was used for continuous DTX delivery. The formulation was well tolerated; no alterations in body weight, behaviour, histology of peritoneal tissues, or interleukin-6 levels were seen in CD-1 mice treated with the PoLigel. Continuous DTX therapy via the PoLigel was considerably more efficacious than intermittent therapy, resulting in significantly less tumor burden and ascites fluid in models of human and murine ovarian cancer. Continuous therapy resulted in less tumor cell proliferation and angiogenesis, and more tumor cell death than intermittent DTX. The presence and length of treatment-free intervals was shown to contribute to the development of drug resistance. Eliminating these intervals by continuous dosing resulted in superior antitumor efficacy in both chemosensitive and chemoresistant xenograft models of human ovarian cancer, and prevented drug resistance increase after a 21-day treatment period. Survival studies revealed that intermittent dosing led to a mild survival prolongation of 36% and 10% in chemosensitive and chemoresistant models, respectively, whereas continuous DTX prolonged survival by a striking 114% and 95%. Although long-term continuous chemotherapy substantially improved survival, increased drug resistance mechanisms were found at the endpoint. Overall, results presented here encourage the clinical implementation of continuous chemotherapy due to greater achievable therapeutic advantages.

Keywords: chemotherapy
ovarian cancer
Advisor: Piquette-Miller, Micheline
South African Music in Transition: A Flutist's Perspective

In April 1994 the citizens of South Africa found themselves in the unique position of contemplating a new national culture; one that would for the first time embrace all South Africans, regardless of race, colour or religion. Official segregation, which began in 1948, ended with the first democratic election held in1994. Cross-cultural awareness in South Africa emerged in the 1980s. Within this temporal context, this investigation will trace parallel developments in the South African classical music genre and will relate these developments to the concurrent socio-political environment. Looking specifically at music written for the flute, the selected works were composed for the flute as a solo instrument, or in combination with up to four other instruments by a cross-section of South African composers who either live in South Africa or who have South African roots. The works included in this study were composed roughly ten years before and after 1994; the purpose being to document the changes that were taking place in South African Art Music leading up to the first democratic election and during the exciting times that followed. The main component of this research is the analysis of the works of nine South African composers, examining cross-cultural content in the musical form: Michael Blake (Honey-Gathering Song, Leaf Carrying Song), Robert Fokkens (Inyoka Etshanini, Cycling to Langa), Hendrik Hofmeyr (Marimba), Hans Huyssen (The Cattle have gone Astray), Bongani Ndodana-Breen (Visions I and II), Isak Roux (Sketches, Four African Scenes), Martin Scherzinger (Whistle of the Circle Movement), Becky Steltzner (Hambani Kakuhle Kwela) and Kevin Volans (Walking Song). Biographical information and compositional philosophies are also included for each composer. In addition, publisher and recording details are provided where they exist. The works contained in this document are organized by cross-cultural borrowing technique: overt cross-cultural borrowing, borrowing guided by African music-making principles, African paraphrasing, and inspirational landscape painting. A brief history of Art Music in South Africa is provided, as is an overview of African musics and instruments. The analysis of each work considers African musical influences and their incorporation, while performance suggestions will also elucidate unique African aspects of the music.

Keywords: South Africa
South African
Art Music
Flute
Africa
Advisor: MacKay, Gillian