VictorJuiz/thesis huggingface dataset:
Whole Body Vibration and Passive Standing for Treatment of Sublesional Osteoporosis after Spinal Cord Injury: Device Optimization & Assessment

Individuals who sustain a spinal cord injury (SCI) experience sublesional osteoporosis (SLOP) which affects the bones of the lower extremities. As a result, these bones become fragile and susceptible to fractures. To tackle SLOP pharmacological and rehabilitation interventions have been proposed; however few have produced a significant and sustainable increase in bone mineral density (BMD). This study investigated whole-body vibration (WBV) as an alternative to tackling SLOP in SCI. Two commercially available vibration platforms, WAVE® and Juvent™, were tested for feasibility and efficacy in the SCI population. The effects of knee angle, frequency and amplitude of vibration in propagation characteristics were also assessed. The results demonstrated that variations in frequency generate the most noticeable changes in propagation characteristics, followed by variations in knee angle and amplitude. The recommended vibration parameters which could potentially have the greatest osteogenic effect on the bones of the lower extremity are 160o, 45 Hz, and 0.6 mm on the WAVE® platform.

Keywords: Whole Body Vibration
Osteoporosis Treatment
Spinal Cord Injury
Propagation Charachteristic
Advisor: Popovic, Milos R.
The Synthesis and Applications of N-alkenyl Aziridines

N-alkenyl aziridines are a unique class of molecules that do not behave as typical enamines as a result of the inability of the nitrogen atom lone-pair of electrons to delocalize. The attenuated nucleophilicity of these enamines presents opportunities for selective functionalization and reactivity not available to classical enamines. An operationally simple and mild copper-mediated coupling has been developed that facilitates the preparation of a broad range of N-alkenyl aziridines not available through existing methods. The preparation and reactivity of highly functionalized N-alkenyl aziridines are reported. Also reported is the application of the chemoselective amine/aldehyde/alkyne (A3) multicomponent coupling involving amphoteric aziridine aldehydes as the aldehyde component. This coupling allows access to propargyl amines with pendent aziridine functionality.

Keywords: Aziridine
N-Alkenyl Aziridine
Advisor: Yudin, Andrei
DREAM-mediated Regulation of GCM1 in the Human Placental Trophoblast

The trophoblast transcription factor glial cell missing-1 (GCM1) regulates asymmetric division of placental cytotrophoblast to form the differentiated syncytiotrophoblast. Reduced GCM1 expression is a key feature of the hypertensive disorder preeclampsia. In-silico techniques identified a novel calcium-dependent transcriptional repressor – DREAM as a regulatory candidate for GCM1. The overall objective of this thesis was to determine if DREAM regulates GCM1 expression and therefore villous trophoblast turnover. siRNA-mediated DREAM silencing in both BeWo cells and floating villous explants significantly upregulated GCM1 causing reduced cytotrophoblast proliferation. Calcium-dependency was demonstrated in both BeWo cells and floating villous explants by contrasting the effects of ionomycin and nimodipine. A direct interaction between DREAM and the GCM1 promoter was demonstrated using EMSA and ChIP assay. DREAM is a negative upstream regulator of GCM1 expression in human placenta that participates in calcium-dependent trophoblast differentiation.

Keywords: placenta
transcriptional regulation
Advisor: Lye, Stephen J.
Ultrasound Imaging of Bone for Spinal Fusion Surgery Guidance: Simulation and Experimental Results

In order to continue development of an ultrasound-guidance system for spinal fusion surgery, simulation and experimental research was conducted to study the effects of bone on ultrasound imaging. Simulation work examined the effect of bone volume and transducer frequency on image quality and accuracy. Experimental work utilized a 3.2MHz prototype ultrasound probe to create ultrasound images of pedicles. The simulation results, based on an idealized anatomical model, provided higher-quality images than the experimental results. It was determined that high bone volume and high transducer frequency have a detrimental effect on image quality. The experimental results suggest that the high variability in pedicle shape results in variability in ultrasound image quality. Overall, the simulation and experimental results suggest that ultrasound imaging of bone is feasible at relatively low frequencies, while highlighting the need for more experiments to take into account the substantial variability in pedicle shape and bone volume.

Keywords: ultrasound
imaging
bone
spinal fusion
Advisor: Cobbold, Richard
Ginsberg, Howard
Keystone Classroom Management: A Practical Approach to Producing Widespread Change in Student Behaviour

Many researchers have pointed out the difficulties teachers face with managing student oppositional behaviour in the classroom. Most pre-service teacher education programs emphasize the curriculum content and the planning of lessons to the exclusion of specialized training in classroom management approaches. This oversight has led to inadequate classroom management skills in many teachers and can result in low teacher self-efficacy and high rates of stress and burnout. Many commonly employed strategies used by teachers to manage problem behaviour focus on reductive consequences that can have a range of negative side effects. Other strategies may be proactive and effective, but are often too complicated and impractical for regular use. In this paper we propose a “keystone” approach to classroom management that may be more efficient and effective for teachers to use in the classroom. With this approach, teachers focus on a circumscribed set of specific classroom skills that have the potential to produce widespread improvement in child outcomes. Empirical support for this approach is discussed.

Keywords: keystone skills
classroom behaviour management
Advisor: Ducharme, Joseph
There is No Choice: Examining Somali Parents' Experience with Special Education

We now have a student population that is culturally, linguistically and economically diverse. This, in turn, has resulted in school board initiatives in response to this diversity, primarily; it appears, in ways that harden social class and racial divisions in the society (Roberston & Kushner, 2006). One clear example of this is the over-representation in Special Education of poor, immigrant students of colour, whose culture and language differs from that of English-speaking Canada. This thesis focuses on the experience of Somali parents whose children have been placed in Special Education or where an attempt has been made to place them. The purpose of this study is to examine if high or low cultural capital among Somali parents’ influences the placement of their children in Special Education. Through qualitative semi-structured interviews, I look at the experience of 8 Somali parents. Thematic analysis of the data is used to understand the findings.

Keywords: Special Education
Minority
Advisor: Livingstone, David W.
The Role of Social Support and Psychological Resources in Depression in People Living with HIV/AIDS: Examining the Mediating Role of Mastery and Self-esteem

The present study explored the influence of social support and psychological resources on depression in people living with HIV/AIDS. The mediating role of mastery and self-esteem was examined. Factor analysis of the MOS-SSS supported three dimensions of social support. Findings from a predominantly gay male sample of unemployed individuals living with HIV/AIDS in the Toronto-area indicated high levels of depressive symptomatology, which were negatively related to emotional/informational support, tangible support, and affectionate/interpersonal support. Mediation analyses indicated partial support of the Cognitive Adaptation Model, revealing significant mediating effects of mastery on the relationship between social support and depressive symptomatology. Self-esteem was not found to be a significant mediator of this relationship. Findings suggest the need for social support interventions that help to strengthen mastery in individuals living with HIV/AIDS in order to reduce depression. Attention should be paid to self-esteem and its relationship with gender and employment status in this population.

Keywords: HIV/AIDS
Social Support
Depression
Mastery
Self-Esteem
Advisor: Gillis, Joseph Roy
Displaced Burmese in Thailand: Refugee Policies and Impact on Access and Rights, 1988-2008

My thesis research centres on the question, how have refugee policy formation and ground level implementation impacted the conditions and experiences of displaced Burmese in Thailand from 1988 to 2008? I examine the effects of the production of subject categories through Thai national laws and practices, a bilateral agreement, and the United Nations Convention on the Status of Refugees, in order to uncover how official policies are used to manage refugees. This study addresses questions regarding policy formation and implementation toward Burmese who have fled political oppression in Burma (Myanmar) and identifies issues related to the recognition of difference and the allocation of rights in the cultural contexts of migration and integration of minority populations. The formulation and implementation of refugee policies has global implications since policy solutions in general are developed from a perspective that ignores the emergence and significance of displacement.

Keywords: Refugee Policies
minority integration
displaced migrants
thailand
policy archaeology
Advisor: Coloma, Roland Sintos
Quarter, Jack
Mindfulness Training for Adolescents with Learning Disabilities

The current study evaluated the impact of a 20-week mindfulness training program on executive function, internalizing and externalizing behaviour, and social skills in a clinical sample of adolescent boys with learning disabilities (LD). Mindfulness Martial Arts (MMA) is a manualized group treatment program incorporating elements of mindfulness meditation, cognitive behavioural therapy, and mixed martial arts. Sixty-five boys (ages 12 – 18) with LD were assigned to the MMA or waitlist control group (WL). Adolescents and their parents completed standardized questionnaires before and after training. Analysis of adolescents with distinct clinical profiles showed promising effects. Compared to the WL group, MMA participants with co-occurring ADHD improved on parent-rated externalizing behaviour, oppositional defiant problems, and conduct problems. Boys with elevated hyperactive/impulsive symptomotology improved on parent-rated social problems and monitoring skills. Boys with elevated anxiety reported decreased anxiety. MMA shows promise as an alternative treatment option for youth with LD and co-occurring difficulties.

Keywords: Mindfulness
Learning Disabilities
ADHD
anxiety
Advisor: Wiener, Judith
Effectiveness of School Policies Prohibiting Adolescent Alcohol and Drug Use

The purpose of this study was to evaluate the effectiveness of school policies aimed to reduce adolescent alcohol and marijuana use. More specifically, the study investigated whether more severe school policy measures are related to the increased or decreased instances of overall alcohol and marijuana use on and beyond school grounds among grade 10 and 12 students. I used data from the National Education Longitudinal Study (NELS). After controlling for a number of prior measures of environmental and demographic factors that are significant predictors of adolescent alcohol and marijuana use, the school policy measures showed no impact on either alcohol or marijuana use at any level of its consumption. This was true for both grade 10 and grade 12 students. The study’s findings suggest that instead of constructing punitive policy measure, policymakers should develop prevention and intervention programs that more specifically target the needs of adolescents, peers, parents, and teachers.

Keywords: school policies
adolescent substance use
policy measures
Advisor: Hong, Guanglei
Democratic Coaching: A Case Study

The thesis is a case study that seeks to understand the democratic coaching style by observing the practices of a specific democratically-minded girls’ varsity hockey coach at a private secondary school in the Greater Toronto Area. The study first characterizes a democratic coach by comparing the democratic leadership style with other styles of leadership; the study then offers a clear understanding of the methods and practices of the case study coach by organizing the findings of the study into four categories: communication techniques, organizational structure, coaching decisions and strategies, and the environment created. Within these four categories, themes emerged that helped answer the following research question: How is democratic coaching understood and practiced by a democratically-minded coach?

Keywords: coaching
democratic
leadership
case
Advisor: Ryan, James
Governing Lived Embodiment: Autism, Asperger's and Care

This thesis brings interpretive disability studies together with a governmentality approach and feminist methodology to think through the meaning of autism, Asperger’s and maternal care. I examine how Asperger’s is articulated as a problem of individual governance through what I call the care complex, an array of practices, knowledges, technologies and institutional locales that attempt to scientifically know and manage alterity under neo-liberal rule. I focus on discourses of inclusion that seek to normalise the movements of alterity through a mother’s care, and reveal how direct and authoritarian forms of power are integral to the accomplishment of this paradoxical version of inclusion and care. The aim of this thesis is to “take care” of autism differently. Thus I also consider how maternal care is lived out and felt, opening analytical space to ask critical questions about power, embodiment and human vulnerability.

Keywords: sociology
interpretive disability studies
women's studies
governmentality
Advisor: Titchkosky, Tanya
Returning Home Through Stories: A Decolonizing Approach to Omushkego Cree Theatre through the Methodological Practices of Native Performance Culture (NPC)

This research examines Native Performance Culture (NPC), a unique practice in Native theatre that returns Aboriginal people to the sources of Aboriginal knowledge, and interrupts the colonial fragmenting processes. By looking at the experiences of six collaborators involved in a specific art project, the artist-researcher shares her journey of healing through the arts, while interweaving the voices of artistic collaborators Monique Mojica, Floyd Favel, and Erika Iserhoff. This study takes a decolonizing framework, and places NPC as a form of Indigenous research while illuminating the methodological discourses of NPC, which are rooted in an inter-dialogue between self-in-relation to family, community, land, and embodied legacies. Finally, this research looks at the ways that artists work with Aboriginal communities and with Aboriginal knowledge, and makes recommendations to improve collaborative approaches.

Keywords: Indigenous Knowledge
Decolonization
Native theatre
Oral Tradition
Cree
Community Art
James Bay
Monique Mojica
Floyd Favel
Erika Iserhoff
Performance
Ontario
Aboriginal
Indigenous Research
Advisor: Restoule, Jean-Paul
French as a Second Language: A Publisher's Perspective

This study examines French-as-a-second-language (FSL) learning in Canada through the lens of an educational publisher. The fields of language and policy planning, second language learning, and educational publishing provide a focus for the study. The principal purpose of this thesis is to identify key stakeholders in second language learning and to analyze the impact of their actions on the development of FSL resources in Canada. Through qualitative field research with representatives from significant Canadian publishing companies, this analysis of relationships and roles will assist future Canadian second language stakeholders in better understanding the impact of their decisions on the field of publishing, on educational resources, and ultimately, on FSL students in classrooms across the country.

Keywords: French as a second language
education stakeholders
FSL
education stakeholders
Advisor: Labrie, Normand
Group-wise 3D MR Image Registration of Mouse Embryos

This dissertation provides the foundations of computer-based automated phenotyping methods for analyzing 3D images of mouse embryos. A group-wise registration technique was utilized and optimized and computerized methods were employed for analysis of 3D MRI images of mouse embryos. The assumption that embryo anatomy is highly conserved among genetically identical specimens was verified. The group-wise registration approach was used to align a group of embryos from the 129S1/SvImJ (129Sv) strain as well as a group of C57BL/6J (C57) embryos. Finally, we shed some light on some of the morphological differences between the 129Sv and C57 strains using automated techniques.

Keywords: image registration
mouse embryo
embryo
group-wise registration
mouse
registration
MRI
phenotyping
embryo anatomy
129S1/SvImJ
C57BL/6J
morphology
Advisor: Sled, John G.
Bridging Theoria and Praxis: Performance Assessments of Water Transmission and Distribution Systems

This thesis is broken into two parts. The first part, Chapters 1 - 7, focuses on work completed performing partial performance assessments in two case studies: the region of Peel in the Greater Toronto Area, and Tláhuac, Mexico. In both, pressure transients were monitored using high-speed sensors. The second part, Chapters 8 - 10, proposes a framework for performance assessments of water transmission and distribution systems, primarily applicable to analysis and operation yet useful in (re)design or additional design work as well. The framework is a synthesis of concepts ranging from fuzzy engineering to psychology and human factors, and will be of particular interest to larger, more sophisticated water utilities who may have a general understanding of their systems but lack specific insights in its operation and operational effectiveness. Careful consideration is given to not only the type of information and possible information fusion, but also details of necessary software and hardware, including possibilities for the system architecture.

Keywords: Performance assessment
Water transmission
Water distribution
Dynamic scorecard
Advisor: Karney, Bryan William
El-Diraby, Tamer
The Relationship Between Insulin Resistance and Hyperinsulinemia on Mammary Cancer Growth and Development

Insulin resistance associated with obesity has been suggested to contribute to an increased risk and poor prognosis for breast cancer. In this study, a HER2/Neu transgenic mouse model of breast cancer was used to assess how obesity-induced insulin resistance and hyperinsulinemia can influence the development and progression of breast cancer. We investigated the effect of a high-fat diet and found a tumor-promoting effect in the absence of overt insulin resistance. In contrast, a high-fat combined with fructose diet induced significant hyperinsulinemia but no tumor promoting or growth effect was observed. Treatment with the anti-diabetic, insulin-lowering agent metformin led to a delay in tumor onset in mice on control diet, but this effect was abrogated by the high-fat fructose diet. These data indicate that the effects and potential interactions of insulin, nutrition and drugs on breast cancer development and progression are complex and require further study.

Keywords: Hyperinsulinemia
Breast Cancer
Advisor: Fantus, I. George
Development of Lanthanide-tagged Substrates Towards the Detection of Proteases by Inductively Coupled Plasma-mass Spectrometry (ICP-MS)

Rapid, sensitive and quantitative assays for proteases are of great significance for drug development and in diagnosis of diseases. Herein, we describe work towards a novel assay for the multiplexed detection of proteases using ICP-MS. Protease substrates were synthesized containing a diethylenetriaminepentaaceticacid(DTPA) ligand to chelate lanthanide metal ions at the N-terminus, providing a distinct tag for each substrate. A biotin label was appended to the C-terminus allowing separation of uncleaved peptide from the digestion. The enzymatic activities can then be determined by detecting the lanthanide signal of the peptide cleavage products by ICP-MS. Substrates synthesized include DTPA-Gln-Val-Tyr-Gly-Nle-Nle-Lys(biotin)-amide, DTPA-Asp-Gln-Val-Asp-Gly-Lys(biotin)-amide and DTPA-Gly-Pro-Gln-Gly-Leu-Glu-Ala-Lys-Lys(biotin)-amide for calpain-1, caspase-3 and MMP-9 They were loaded with terbium, holmium and praseodymium respectively. As a proof-of-concept, α-chymotrypsin assays were carried out using DTPA-Asp-Leu-Leu-Val-Tyr-Asp-Lys(Biotin) loaded with lutetium, as a substrate. Calpain-1 assays were also performed. Parallel assays with commercially available fluorogenic substrates for both the enzymes were performed for comparison.

Keywords: Detection of proteases
chymotrypsin
ICP-MS
Lanthanides
Advisor: Nitz, Mark
Near-infrared Spectroscopy Signal Classification: Towards a Brain-computer Interface

A brain-computer interface (BCI) allows individuals to communicate through the modulation of regional brain activity. Clinical near-infrared spectroscopy (NIRS) is used to monitor changes in cerebral blood oxygenation due to functional activation. It was hypothesized that visually-cued emotional induction tasks can elicit detectable activity in the prefrontal cortex. Data were collected from eleven participants as they performed positively and negatively-valenced emotional induction tasks. Baseline and activation trials were classified offline with accuracies from 75.0-96.7% after applying a feature selection algorithm to determine optimal performance parameters for each participant. Feature selection identified common discriminatory features across participants and relationships between performance parameters. Additionally, classification accuracy was used to quantify NIRS hemodynamic response latency. Significant increases in classification rates were found as early as 2.5 s after initial stimulus presentation. These results suggest the potential application of emotional induction as a NIRS-BCI control paradigm.

Keywords: Near-infrared spectroscopy
Brain-computer interface
Locked-in syndrome
Emotional induction
Advisor: Chau, Tom
Development of a High-order Finite-volume Method for the Navier-Stokes Equations in Three Dimensions

The continued research and development of high-order methods in Computational Fluid Dynamics (CFD) is primarily motivated by their potential to significantly reduce the computational cost and memory usage required to obtain a solution to a desired level of accuracy. In this work, a high-order Central Essentially Non-Oscillatory (CENO) finite-volume scheme is developed for the Euler and Navier-Stokes equations in three dimensions. The proposed CENO scheme is based on a hybrid solution reconstruction procedure using a fixed central stencil. A solution smoothness indicator facilitates the hybrid switching between a high-order k-exact reconstruction technique, and a monotonicity preserving limited piecewise linear reconstruction algorithm. The resulting scheme is applied to the compressible forms of the Euler and Navier-Stokes equations in three dimensions. The latter of which includes the application of this high-order work to the Large Eddy Simulation (LES) of turbulent non-reacting flows.

Keywords: Computational Fluid Dynamics
High-Order
Finite-Volume
Navier-Stokes Equations
Euler Equations
CENO
Advisor: Groth, Clinton P. T.