VictorJuiz/thesis huggingface dataset:
Education and employment: transitional experiences in Nepal

This thesis explores the relationship between education and employment, particularly as it affects the socio-economic mobility of people from poor and marginalized communities in Nepal. I carry out a multi-sited, inter-generational analysis to investigate the aspirations, expectations, and experiences of young people. Based on ethnographic and participatory fieldwork in a village and a school in the outskirts of Lalitpur in 2012, this research grows organically to provide a detailed review of current schooling practices and their employment as well as wider implications in Nepal.
Theoretically, this thesis investigates the experiences of the marginalized in terms of the relevance, level, and quality of their education. I examine the role of education as a socializing institution as well as its characteristics as a social and a positional good. I assess the outcomes of their education through internal measures (such as exam scores and pass rates) but also extend the analysis to include external ones (such as job opportunities and life trajectories). I focus on the deterministic life-stages model of transition to challenge the expectation that children go to school, acquire skills, obtain jobs, and become 'adults'.
People have historically placed high hopes on education, but the potential for socio-economic mobility for the poor and marginalized are limited by the failures of the school system, sustained challenges to higher education access, limited relevance of education to employment opportunities, and continued prominence of social and cultural capital to secure jobs. Yet, their educational engagement has provided some benefits even as their expectations for gainful employment have not been met. Schooling has become an integral part of childhood, but foreign migration is emerging as a prominent alternative avenue for the aspirant youth. Further, the distinctions between children and adults are also blurred as students balance their transitions between school, work, and home to succeed within the system.

Keywords: international development
employment transitions
Education: employment and transitions
marginalised communities
inequality
Nepal
Advisor: Boyden, J
Emission targets for avoiding dangerous climate change

A number of recent studies have found a strong link between peak global warming due to anthropogenic carbon dioxide and cumulative carbon emissions from the start of the industrial revolution. This thesis builds on this work by using a simple climate model to apply the concept of cumulative emissions to emission floors, by comparing cumulative emissions with other types of emissions target, and by extending the work to apply to noncarbon dioxide (CO2) greenhouse gases and short-lived climate forcers (SLCFs).
Though peak global warming correlates well with cumulative carbon emissions, the link to emissions over shorter periods or in the years 2020 or 2050 is shown to be weaker. It is also shown that the introduction of emissions floors does not reduce the importance of cumulative emissions, but may make some warming targets unachievable. For pathways that give a most likely warming up to about 4°C, cumulative emissions from pre-industrial times to year 2200 correlate strongly with most likely resultant peak warming in the simple model used, regardless of the type of emissions floor used. The maximum rate of CO2- induced warming is not determined by cumulative emissions but is shown to be limited by the peak rate of CO2 emissions. A simple model of non-CO2 greenhouse gases is also developed and used to investigate SLCFs. It is shown that emissions of SLCFs today have little impact on peak warming, and that delaying near-term reductions in SLCFs would not have a significant impact on peak warming. Only once CO2 emissions are falling do SLCF emissions have a significant impact on peak warming. A global climate policy framework is presented as an example of how the work in this thesis could be used in policy. Future work is also discussed, particularly verification of these results in a more complex model.

Keywords: carbon emissions
Climate change
emission floor
cumulative emissions
emission targets
Advisor: Allen, M
Frame, D
Lowe, J
The performance of future wireless communication systems

Multimedia services provided through wireless networks, such as mobile television and video calls, have recently attracted great attention. These systems require higher data rates, better communication quality, and wider channel bandwidth compared with traditional wireless network services, such as voice calling and text messaging. In response to these demands, multiple-input multiple-output (MIMO) employing multiple antennas at both transmitter and receiver, has been investigated in recent years. Nevertheless, the major impediment in MIMO based wireless systems is the cost of the hardware due to the requirement of the complete radio frequency (RF) chain for each transmit and receive path. One technique named antenna subset selection has been proposed which can reduce the hardware complexity, for example, provide and smaller number of RF chains which are reconfigurable to serve multiple antennas, but retain good communication performance, such as increasing data rates and improving communication quality. On the other hand, network service providers have in recent years established wideband communication systems in order to provide more services and higher bandwidth to customers. However, this development lowers the communication link quality, since signals transmitted in wideband communication systems suffer frequency-selective fading. In order to reduce the fading, orthogonal frequency division multiplexing (OFDM) as a potential infrastructure in the fourth generation mobile communication networks is developed. Referring to the cost-performance ratio, an attractive future wireless system named antenna selection based MIMO-OFDM is considered to be widely utilized in civil wireless communications in near future. The working theory of antenna selection based MIMO-OFDM systems can be simply represented as that a data stream at each selected transmit/receiver antenna is sent/receive over a number of narrow band orthogonal subcarriers.
This thesis addresses analysis of wireless channel and performance investigation of future wireless communication systems, such as MIMO and OFDM structures. Moreover, a novel significantly low computational complexity algorithm is introduced in this thesis, which is proposed for antenna selection MIMO-OFDM systems on the basis of multiple selection criteria. It is shown that the proposed selection algorithm clearly reduces the computational complexity load of the selection process and efficiently selects the optimum antenna subset of antenna selection MIMO-OFDM systems. The thesis concludes by outlining the advantage of the proposed antenna selection technique and points out its potential role in future wireless communications.

Keywords: ofdm
mimo
amcmc
antenna selection
Advisor: Edwards, D
The synthesis and applications of cyclic alkenylsiloxanes

This thesis describes the development of robust methodology to access cyclic alkenylsiloxanes, and their subsequent application in Hiyama-Denmark cross couplings. An early chapter shows the identification of Lindlar reduction conditions capable of generating cyclic alkenylsiloxanes from alkynylsiloxanes in high yields. The use of such species in Hiyama-Denmark cross coupling is then examined, with particular emphasis on the development of fluoride-free conditions, previously unreported for this class of organosilane.
A ring-size dependent orthogonality is revealed, where 5-membered cyclic alkenylsiloxanes cross couple under basic conditions, while 6-membered analogues are inert. The origins of this effect are investigated experimentally and theoretically, leading to the proposal of detailed mechanisms for coupling. In the final chapter, the methodology that has been developed is applied to total synthesis. The great potential of the orthogonality uncovered is demonstrated with the highly convergent construction of anti-inflammatory natural product resolvin D3 by sequential, one-pot, orthogonal cross couplings.

Keywords: cross coupling
natural product synthesis
silicon
Advisor: Anderson, E
Macrophage-HIV interactions

HIV-1 has evolved a number of strategies in response to current anti-retroviral drugs and the selection pressure of humoral and cellular immunity. In particular, R5 viral strains that are essential for AIDS pathogenesis are very resistant to neutralization by antibodies. Therefore, the aim of this thesis was to develop synthetic nucleic acid ligands, aptamers, against gp120 of an R5 strain of HIV-1, with a view of using aptamers as novel neutralization molecules and analytical tools to study HIV-1 entry into target cells. The central hypothesis of this thesis was that aptamers by virtue of their small size and slow dissociation rates, compared to antibodies, would easily access and bind occluded gp120 neutralization sites.
Using the SELEX protocol and SPR technology, I isolated 2'-Fluoro-pyrimidine-RNA aptamers against HIV-lBa-L monomeric gp120. Most of these aptamers not only bound gp120 with high affinities but also neutralized R5 primary isolates in human PBMC by 1,000 to 100,000-fold, truly unprecedented when compared with natural ligands such as antibodies. Some aptamers, like B4, defined a conserved site of gp120 that could not mutate to escape neutralization following stringent selection, in vitro, for breakthrough virus. This was consistent with subsequent findings that B4 aptatope (binding site) overlaps a poorly immunogenic but highly conserved CD4-induced epitope as determined by competition with 17b and 48d mAbs that map to this neutralization epitope on the gp120. This study was thus the first of its kind to describe neutralization of HIV-1 primary isolates by a ligand against the CD4-induced epitope. Most intriguing, although B4 potently neutralized HIV-1Ba-L infection in PBMC, which is a mixed T cell and macrophage population, it modestly neutralized infection of the same virus in a purified culture of macrophages. These findings are intriguing in that they suggest that aptamers could be used to dissect unique sites on the virus that interact with target cell surface in ways that have not been revealed heretofore, and would help understand better HIV-1 entry pathways, especially in macrophages. Thus neutralizing aptamers such as these could be exploited to provide leads in developing alternative anti-HIV-1 drugs and a deeper understanding of the molecular interactions between the virus and its host cell.

Advisor: James, W
Gordon, S
Regulation of stemness and differentiation in colorectal cancer

The cancer stem cell (CSC) model of carcinogenesis and progression posits that within a tumor lies a subpopulation of cells that solely possess the ability to initiate a tumor and to differentiate into tumor cell lineages. Although the behavior of such cells is known, the challenge is to identify factors that characterize the CSC subpopulation. In this thesis, cell lines were identified that, when grown in three-dimensions, gave rise to organized colonies containing lumens originating from differentiating cells (“lumen lines”) and to densely-packed, spherical colonies originating from non-differentiating cells (“dense lines”). A microarray comparison of the pair identified genes upregulated in dense lines, including CD55 and BMI1, and in lumen lines, including CDX1 (Chapter 3). CD55 was used to isolate CD55high CSCs via flow cytometry that are able to self-renew, differentiate, initiate more colonies, proliferate more rapidly and exhibit an increased G2/M cell cycle population as opposed to unfractionated cells. Furthermore, the CD55high cells were able to give rise to more differentiated, lumen colonies in vitro, indicating that CD55 enriches for cells possessing a capacity to differentiate, and were able to enrich the CD24highCD44high putative CSC population further (Chapter 4). CDNA induction of BMI1 and CDX1 expression led to increased clonogenicity/proliferation and decreased clonogenicity/proliferation, respectively, and incorporation of a CDX1 reporter construct into the SW1222 cell line identified CDX1+ cells as a low-expressing population of CD55 (Chapter 5). Finally, co-culture of cell lines in an in vivo-like environment with intestinal myofibroblasts promoted the CSC population by enhancing clonogenicity, proliferation and expression of CD55 (Chapter 6). The results of this thesis implicate CD55 as a potent marker of colorectal cancer stemness, link the expression of BMI1 and CDX1 to cancer stemness and differentiation, respectively, and identify a role for the in vivo stem cell niche in maintaining the CSC population.

Keywords: oncology
stem cell biology
colon
gastroenterology
cancer stem cells
colorectal cancer
cancer biology
Advisor: Bodmer, W
Step IV of the muon ionization cooling experiment (MICE) and the multiple scattering of muons

The Muon Ionization Cooling Experiment (MICE) is the first technical demonstration of muon ionization cooling, using a prototype section of a Neutrino Factory cooling channel. MICE is currently under construction at the Rutherford-Appleton Laboratory in the UK and will make the first cooling measurements in 2015, in Step IV of the experimental programme.
Cooling predictions in Monte Carlo simulations of Step IV were found to disagree with the predictions of the 'cooling formula', a widely-used approximation, by up to 30% in liquid hydrogen (LH2). This disagreement was shown to originate, largely, from the multiple scattering expression used in the cooling formula. It was necessary to go back to the fundamental physics of scattering to derive a more accurate expression that includes scattering from atomic electrons. A modified form of the cooling formula was derived using this expression and gave better agreement with the Monte Carlo in LH2. Predictions are given for the equilibrium emittance, using the new expression, for seven low Z materials at muon momenta of 140, 200 and 240 MeV/c.
Theories which predict the distribution of multiple scattering angles are briefly reviewed, focusing on Moliere theory and its variants, which are the most widely-used theories. The distributions predicted by these theories are used in most Monte Carlo codes but their implementation is not transparent, especially regarding the treatment of scatters with atomic electrons, which are important in low Z materials. A simple Monte Carlo model to predict multiple scattering distributions was developed that correctly treats scatters off electrons. The model gives very good agreement with measurements by the MuScat Experiment.
Investigations were made into the possibility of measuring multiple scattering in MICE Step IV, both with and without the magnetic field. Preliminary results suggest that measurements are easier with no magnetic field, where tracks are straight. Corrections to account for the resolution of the scintillating-fibre trackers are required in both cases, but these are substantially smaller when straight tracks are used.

Keywords: MICE
multiple scattering
muon
MuScat
ionization cooling
Advisor: Cobb, J
Rethinking federalism

This thesis is motivated by uncertainty in the academic literature surrounding the meaning of federalism and the appropriate usage of the concept to describe political systems. In particular, its use in characterising systems of regional integration which have moved beyond a strictly inter-governmental character, but not yet reached Statehood, is today highly contested, as in the case of the European Union. The established consensus that this entity constitutes a wholly novel ‘sui generis’ form, neither federal nor confederal in character, has been tempered in recent years by a growing willingness among scholars to deploy the lens of comparative federalism to analyse the polity. However, the precise relevance of the concept in this new context remains unsettled.
Can political science achieve any more definite understanding that removes such doubt? I consider this question through the perspective of the history of ideas, by examining the evolution of federalism from inception to the present day.
I argue that the history of the federal idea in the United States reveals that the heart of the problem lies in confusion over the nature of sovereignty. Ever since Philadelphia federalism has been thought to mean ‘a division of sovereignty’. However, the subsequent Civil War did appear to demonstrate that the notion of sovereignty shared between two levels of government was a false construction: either the whole or the parts could be sovereign, but not both simultaneously. This point, it seems - the indivisibility of sovereignty - was not fully taken on board afterwards in the United States and elsewhere. The thesis seeks to put this right and to systematically relate the evolving concept of federalism with the evolving and contested nature of sovereignty.
On this ground, I suggest that we clarify the definition of federalism as ‘a division of the powers flowing from sovereignty’. This in turn yields two specific varieties of ‘compound polity’ where before only one was known: the single State and multi-State federal forms. The latter has to date been an unobserved species, which, it would seem, the fact of the EU’s existence now forces us to recognize.

Keywords: federation
integration
confederation
sovereignty
federalism
Advisor: Nicolaidis, K
Religious reform, transnational poetics, and literary tradition in the work of Thomas Hoccleve

This study considers Thomas Hoccleve’s role, throughout his works, as a “religious” writer: as an individual who engages seriously with the dynamics of heresy and ecclesiastical reform, who contributes to traditions of vernacular devotional writing, and who raises the question of how Christianity manifests on personal as well as political levels – and in environments that are at once London-based, national, and international. The chapters focus, respectively, on the role of reading and moralization in the Series; the language of “vice and virtue” in the Epistle of Cupid; the moral version of Chaucer introduced in the Regiment of Princes; the construction of the Hoccleve persona in the Regiment; and the representation of the Eucharist throughout Hoccleve’s works.
One main focus of the study is Hoccleve’s mediating influence in presenting a moral version of Chaucer in his Regiment. This study argues that Hoccleve’s Chaucer is not a pre-established artifact, but rather a Hocclevian invention, and it indicates the transnational literary, political, and religious contexts that align in Hoccleve’s presentation of his poetic predecessor. Rather than posit the Hoccleve-Chaucer relationship as one of Oedipal anxiety, as other critics have done, this study indicates the way in which Hoccleve’s Chaucer evolves in response to poetic anxiety not towards Chaucer himself, but rather towards an increasingly restrictive intellectual and ecclesiastical climate.
This thesis contributes to the recently revitalized critical dialogue surrounding the role and function of fifteenth-century English literature, and the effect on poetry of heresy, the church’s response to heresy, and ecclesiastical reform both in England and in Europe. It also advances critical narratives regarding Hoccleve’s response to contemporary French poetry; the role of confession, sacramental discourse, and devotional images in Hoccleve’s work; and Hoccleve’s impact on literary tradition.

Keywords: Roman de la Rose
Regiment of Princes
Late-Medieval Italian Poetry
Nicholas Brigham
Thomas Hoccleve
George Ashby
John Lydgate
Christine de Pizan
Archbishop Thomas Arundel
Late-Medieval French Poetry
Archbishop Henry Chichele
John Gower
Eustache Deschamps
The Series
Chaucerian writing
Religious Reform
Jean de Meun
Canterbury Tales
Divine Comedy
Epistle of Cupid
Late-Medieval Religious Writing
Late-Medieval English Poetry
William Langland
Transnational Poetry
Ecclesiastical Reform
Literary Criticism
English literary tradition
Late-Medieval Church Reform
Commedia
Troilus and Criseyde
Dante Alighieri
Geoffrey Chaucer
Mum and the Sothsegger
Piers Plowman
Orthodoxy
Richard the Redeless
Heresy
Advisor: Gillespie, V
British naval manpower during the French Revolutionary wars, 1793-1802

Throughout the age of sail, with the exception of finance, there was no aspect of naval warfare that exhibited as much difficulty and anguish as manning the fleet. Finding the necessary skilled seamen to man warships was the alpha and omega of problems for the Royal Navy, as in wartime it was the first to appear with mobilisation and the last to be overcome. Manning the Royal Navy was an increasing problem throughout the eighteenth century as the Navy and British sea trade continuously expanded. This resulted in a desperate struggle for the scarce resource of skilled manpower, made most evident during the initial mobilisation from peacetime to wartime footing.
There is no doubt that the Royal Navy depended on able seamen as if they were the very lifeblood of the ships on which they served. In manning its fleets the Royal Navy had to also consider the merchant marine, which depended upon skilled mariners and supplied the British Isles with food, stores, and the economic income generated by sea trade. The task of manning the fleets proved extremely difficult and was only accomplished under great stress as both the Royal Navy and the merchant marine struggled to obtain the services of vitally important skilled mariners. Therefore the fruits of the Royal Navy’s avid search for seamen during the French Revolutionary Wars must be viewed in light of its success in dominating the oceans of the world. This research proves that the Admiralty of the British Royal Navy was as concerned and as cautious in manning warships as they were in fighting them. It also shows that much of what history has said about naval manning has been based on conjecture rather than fact. This research utilizes statistics to reanalyze naval manning and provide a basis for future research.

Keywords: naval history
Advisor: Rodger, NAM
Thermomechanical properties of polymers at high rates of strain

The objective of this project was to develop a suitable testing technique which will allow the measurement of the bulk surface temperature of a specimen during high strain-rate compression testing. A fast response infra-red radiometer was developed which has the capability of measuring bulk surface temperature changes with an estimated accuracy of ±2°C and with a response time of 1.4μs. The radiometer is capable of measuring temperature changes above 20°C, when the signal-to-noise ratio becomes greater than 1.
The properties of polymeric materials are extremely temperature sensitive, particularly when the glass transition temperature is approached. Models such as Eyring predict the yield of a polymer at constant temperature; the yield stress being unaffected by temperature rises. Temperature as well as mechanical data will allow models to be revised to include strain and dynamic temperature terms to predict the flow under adiabatic conditions. Strain-rates of ca. 2500s-1 were achieved when testing specimens and this rate was obtained using a split Hopkinson pressure bar. A substantial number of preliminary tests were conducted in order to obtain a suitable specimen size which was then used in the temperature measurement process. Quasistatic, intermediate and high strain-rate tests were performed; the last utilised the radiometer for temperature measurement. An Eyring plot was constructed from which fundamental values for activation volumes and enthalpies were obtained. Full descriptions of the testing techniques used have been included and a brief photoelastic analysis has been carried out on a partially deformed specimen which shows molecular alignment.