VictorJuiz/thesis huggingface dataset:
"Three Hundred Leagues Further into the Wilderness" Conceptualizations of the Nonhuman during Wendat-French Culture Contact, 1609-1649: Implications for Environmental Social Work and Social Justice

This study concerns an essential but, until recent years, little explored area of social work: environmental social work. The social work profession has long considered persons in their environment; however, use of the term environment has typically referred to social rather than nonhuman physical dimensions of space and place. It is common knowledge that we face today a number of serious environmental challenges, but less common is an understanding of how things came to be as they are. Why, for example, did things not develop differently? Why is our human-nonhuman relationship so strained? This research asserts human conceptualisations of the nonhuman other influence treatment of not only the nonhuman but also other human beings. Having an interdisciplinary focus involving social work, environmental studies and early Canadian history, Wendat and French conceptualisations of the nonhuman are explored through an ecofeminist framework in a culture-contact context to initiate consideration of, and in due course attending to, the uneasy intersection of the human and the nonhuman, social work and environmental issues, and current Aboriginal-non-Aboriginal relations. Through locating our environmental crisis within a historical context, it is possible to unsettle some contemporary assumptions about the human-nonhuman relationship, drawing attention to the fact that things could have been otherwise, that the environmental challenges experienced today were not inescapable. While there are certainly many ways to approach a history of our present environmental crisis, this investigation in the Canadian context involving a clearly defined case of culture contact between the Wendat and French in the early seventeenth century offers a variety of advantages deriving, in part, from the comparable but different complexities belonging to each group and the opportunity to explore two highly dissimilar cultural practices and belief systems from the time of initial contact. This study examines in detail how the two cultures understood and interacted with the nonhuman, and each other, through a forty-year period from 1609-1649. From this historical exploration of Wendat and French worldviews and land-use practices implications for social work are described and a model for place-based social work is generated.

Keywords: environmental social work
Wendat-French culture contact
human-nonhuman relations
Advisor: Chambon, Adrienne S.
Studies on Signal Transduction Mechanisms in Rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma of childhood, with two predominant histologic subtypes: embryonal and alveolar. These histologies display distinct clinical courses, and despite refinements in dose and duration of multimodality therapy, the 5-year overall survival of patients diagnosed with metastatic RMS remains <30%. Thus, there is an urgent need to define novel targets for therapeutic intervention. Interrogation of cancer cell signal transduction pathways that regulate the pathogenic behaviours of tumor cells has been successful in defining targets in numerous tumor types. These have ultimately yielded clinically-relevant drugs that have improved the disease-free and overall survival of patients diagnosed with cancer. Work contained in this thesis describes the interrogation of several potential targets for inhibition in RMS. Interruption of RMS cell proliferation, survival and apoptosis is examined through disruption of the protein kinase integrin-linked kinase (ILK) and the nuclear receptor estrogen-receptor β. ILK, in particular, is demonstrated to have dual competing functions through the regulation of c-jun amino-terminal kinase (JNK) signaling: an oncogene in alveolar, and a tumor suppressor in embryonal RMS. These findings are recapitulated in other tumor cell lines, indicating that expression levels of JNK1 correlate with ILK function in a broad spectrum of tumor types. Furthermore, interruption of rhabdomyosarcoma cell migration as a surrogate marker of metastasis is examined through disruption of the stromal-cell derived factor 1α/chemokine (CXC)receptor 4 signaling network, as well as through cooperative interactions between ILK and the mammalian target of rapamycin. Finally, we demonstrate that the insulin-like growth factor pathway is a potential target for therapeutic inhibition, which also distinguishes tumors of embryonal and alveolar histology. These studies provide a rationale for the development of novel agents, as well as the use of established drugs targeting these pathways in rhabdomyosarcoma.

Keywords: rhabdomyosarcoma
cell signaling
tumor suppressor
oncogene
metastasis
insulin-like growth factor
chemokine
cancer
translocation
signal transduction
estrogen receptor
integrin-linked kinase
JNK
c-jun
embryonal
alveolar
mTOR
myosin light chain
Advisor: Malkin, David
Chemical Genetic Interrogation of Neural Stem Cells: Phenotype and Function of Neurotransmitter Pathways in Normal and Brain Tumor Initiating Neural Precursor Cells

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain brings promise for the treatment of neurological diseases and has yielded new insight into brain cancer. The complete repertoire of signaling pathways that governs these cells however remains largely uncharacterized. This thesis describes how chemical genetic approaches can be used to probe and better define the operational circuitry of the NSC. I describe the development of a small molecule chemical genetic screen of NSCs that uncovered an unappreciated precursor role of a number of neurotransmitter pathways commonly thought to operate primarily in the mature central nervous system (CNS). Given the similarities between stem cells and cancer, I then translated this knowledge to demonstrate that these neurotransmitter regulatory effects are also conserved within cultures of cancer stem cells. I then provide experimental and epidemiologically support for this hypothesis and suggest that neurotransmitter signals may also regulate the expansion of precursor cells that drive tumor growth in the brain. Specifically, I first evaluate the effects of neurochemicals in mouse models of brain tumors. I then outline a retrospective meta-analysis of brain tumor incidence rates in psychiatric patients presumed to be chronically taking neuromodulators similar to those identified in the initial screen. Lastly, by further exploring the phenotype and function of neurotransmitter pathways in purified populations of human NSCs, I determined that neurotransmitter pathway gene expression exists in a functionally heterogeneous phase-varying state that restricts the responsiveness of these populations to various stimuli. Taken together, this research provides novel insights into the phenotypic and functional landscape of neurotransmitter pathways in both normal and cancer-derived NSCs. In additional to a better fundamental understanding of NSC biology, these results suggest how clinically approved neuromodulators can be used to remodel the mature CNS and find application in the treatment of brain cancer.

Keywords: Chemical Biology
Neural Stem Cells
Neurotransmitters
Cancer
Advisor: Tyers, Michael D.
Dirks, Peter Benjamin
Autonomous Infrastructure Based Multihop Cellular Networks

In a multihop cellular network, mobile terminals have the capability to transmit directly to other mobile terminals enabling them to use other terminals as relays to forward traffic towards the base station. Previous studies of networks consisting of a single cell found that the SINR in a multihop cellular network is slightly lower than in a traditional cellular network. However, multihop cellular networks may have a higher capacity than traditional cellular networks due to their potential for lower intercell interference. For this reason, the effects of intercell interference are investigated in this thesis. Our simulations of a network with many cells show that multihop cellular networks have a higher SINR than traditional cellular networks due to the near elimination of intercell interference. However, multihop cellular networks still suffer from large amounts of interference surrounding the base station because all traffic either emanates or is destined to the base station making it the capacity bottleneck. To resolve this problem, we propose a novel architecture called the autonomous infrastructure multihop cellular network where users can connect their mobile terminals to the backbone network giving them the functionality of an access point. Access points receive traffic from other terminals and send it directly onto the backbone, as would a base station. This reduces the traffic handled by the base station and increases network capacity. Our analysis and simulations show that in autonomous infrastructure multihop cellular networks, the SINR at the base station is higher, the power consumption is lower and the coverage is better than in normal multihop cellular networks. Access points require parameters like their transmission range to be adjusted autonomously to optimal levels. In this thesis, we propose an autonomous pilot power protocol. Our results show that by adjusting a parameter within the protocol, a required coverage level of terminals can be specified and achieved without knowledge of the location or density of mobile terminals. Furthermore, we show that the protocol determines the transmission range that is optimal in terms of SINR and power consumption that achieves the required coverage while effectively eliminating the bottleneck that existed at the base station.

Keywords: wireless communications
multihop cellular networks
CDMA
cooperative networks
autonomous infrastructure
relaying
pilot power protocol
optimal transmission range
Advisor: Sousa, Elvino Silveira
Multiparty Communication Complexity

Communication complexity is an area of complexity theory that studies an abstract model of computation called a communication protocol. In a k-player communication protocol, an input to a known function is partitioned into k pieces of n bits each, and each piece is assigned to one of the players in the protocol. The goal of the players is to evaluate the function on the distributed input by using as little communication as possible. In a Number-On-Forehead (NOF) protocol, the input piece assigned to each player is metaphorically placed on that player's forehead, so that each player sees everyone else's input but its own. In a Number-In-Hand (NIH) protocol, the piece assigned to each player is seen only by that player. Overall, the study of communication protocols has been used to obtain lower bounds and impossibility results for a wide variety of other models of computation. Two of the main contributions presented in this thesis are negative results on the NOF model of communication, identifying limitations of NOF protocols. Together, these results consitute stepping stones towards a better fundamental understanding of this model. As the first contribution, we show that randomized NOF protocols are exponentially more powerful than deterministic NOF protocols, as long as k ≤ nC for some constant c. As the second contribution, we show that nondeterministic NOF protocols are exponentially more powerful than randomized NOF protocols, as long as k ≤ δ·log n for some constant δ < 1.</p> For the third major contribution, we turn to the NIH model and we present a positive result. Informally, we show that a NIH communication protocol for a function f can simulate a Stack Machine (a Turing Machine augmented with a stack) for a related function F, consisting of several instances of f bundled together. Using this simulation and known communication complexity lower bounds, we obtain the first known (space vs. number of passes) trade-off lower bounds for Stack Machines.

Keywords: communication complexity
number on forehead
class separation
determinism
randomization
nondeterminism
stack machines
lower bound
Advisor: Pitassi, Toniann
Ancient Rhetoric and the Synoptic Problem

Only recently have studies of the synoptic problem begun to ground their assessments of literary dependence in ancient conventions. In an effort to appreciate more fully the evangelists’ modus operandi, our study examines their appeal to Greco-Roman rhetoric, the “science of speaking well.” Focusing on a rhetorical form called the chreia (xrei/a), we examine rhetorical techniques and reasons for chreia adaptation, particularly reasons why authors changed this form in theory and in the practice of the Hellenistic authors Plutarch and Josephus. With these reasons in mind, we assess literary dependence among the synoptic gospels, focusing on one chreia in the Triple Tradition (Matt. 9:14-17/Mark 2:18-22/Luke 5:33-39) and another in the Double Tradition (Matt. 12:22-37/Mark 3:20-35/Luke 11:14-36). Our study illustrates that hypotheses of Markan priority, like the Farrer Hypothesis and Two-Document Hypothesis, are more rhetorically plausible than hypotheses of Matthean priority. While Matthew and Luke’s adaptations of Mark reflect the rhetorical reasoning that we should expect, Mark’s reasoning is often problematic, for Mark repeatedly works against the fundamental rhetorical principles of clarity and propriety.

Keywords: Religion
New Testament
Advisor: Kloppenborg, John S.
Life Histories of Culturally Diverse Canadian Leaders: A Study of Agency and Identity

This qualitative study explores the life history of four immigrants from diverse cultures, who have effectively navigated cultural differences and attained high-level leadership positions in Canada. The leaders’ life stories highlight key experiences that have influenced their identities, that is, the distinctive characteristics that are the source of their individual self definition and self-respect. The purpose of the study is to understand how social identity influences immigrants’ sense of personal agency and their capacity to shape individual potentialities into personal abilities. The study is situated in the leadership field within the multicultural Canadian context. It is grounded in my personal experiences as an Iranian-Canadian immigrant and guided by multidisciplinary literature on leadership, culture, identity, and motivation. Globalization, economic interdependence, and growing cross-national mobility have changed the face of the Canadian multicultural society. The clash of world-views, values, and life styles have become unavoidable, with arguably all Canadians experiencing the feeling of being “other” in their interactions with members of other cultures. Within the new Canadian mosaic, cultural consciousness is on the rise leading to increasing ethnic distinctiveness. It has become a factor distinguishing individuals by their differences as well as grouping them together by their similarities. Living in a multicultural environment as an immigrant has implications on issues of identity, but these implications have not yet been thoroughly explored. Much of existing cultural research is based on national orientation and contentious dualism (e.g., individualism and collectivism). But, cultures are dynamic and diverse. Understanding cultural constructs at the individual rather than the national level demonstrates the complexity and variability of individuals in the exercise of personal agency and the construction of identity. Through sharing and understanding the experience of four immigrants in leadership positions across diverse organizations, researchers may learn about immigrant challenges and ways these four individuals reconcile differences and conflicting cultural values. The resulting practical implication is (a) increased self and social awareness for immigrants with high potential for leadership, (b) enhanced multicultural knowledge for current organizational leaders, and (c) improved interpersonal relationships within a broad multicultural community.

Keywords: agency
leadership development
cross cultural studies
Canadian immigrants
Advisor: Cole, Ardra
The Influence of Lexical Characteristics on Sentence Production in Younger and Older Adults

In the study of language production in aging, an important question relates to the relationship between lexical retrieval and syntactic production. Studies have reported changes in syntactic production across the lifespan, but their underlying cause remains unclear. In younger adults, it has been suggested that lexical factors, such as an item‟s semantic or phonological representation influence syntactic production; however, the full nature of this influence remains unclear. Studies investigating the type of sentence produced have found semantic facilitation and phonological interference (e.g., Bock, 1986, 1987), but studies investigating response time (e.g., Meyer, 1996) have found the opposite effects. This investigation sought to examine the influence of lexical level information on sentence production in younger and older adults. This was accomplished by concurrently examining reaction time and sentence type effects. In Experiment 1, 61 adults (mean age: 21.8 years) were presented with pictures and distractor words (unrelated, or semantically or phonologically related). Three stimulus onset asynchronies (SOA) were used (-1000ms, -150ms and 150ms). Participants were required to describe each picture. Using an analysis of variance, response time was compared across the different conditions and using generalized estimating equations, the type of sentence produced and the position of the primed word were compared. In Experiment 2, phonological distractors were excluded, and one SOA (-150ms) was used. Testing involved 83 younger adults (mean age: 22.9 years) and 56 older adults (mean age: 74.7 years). In Experiment 1, semantic distractors resulted in related nouns being produced more often in the subject position. This effect was observed in the analysis of the position of the target noun, but not in the analysis of the type of sentence produced. There were no effects of phonological distractors. In Experiment 2, semantic distractors influenced the type of sentence produced for both age groups. The groups differed only in error production. No reaction time effects were observed in either experiment. This investigation successfully demonstrated an influence of lexical level information on the syntactic productions of younger and older adults. The two groups were similar in their productions, suggesting that aspects of syntactic production are preserved in older adults.

Keywords: sentence production
lexical retrieval
soa
picture-word interference task
reaction time
psycholinguistics
aging
Advisor: Rochon, Elizabeth
The Auxilia in Roman Britain and the Two Germanies from Augustus to Caracalla: Family, Religion and ‘Romanization’

This thesis examines the cultural and social relationships cultivated by ethnically diverse auxiliary soldiers in the western Roman empire. These soldiers were enrolled in the Roman auxilia, military units that drew primarily on the non-Roman subjects of the empire for their recruits in numbers that equaled the legionaries. I argue that auxiliary soldiers could and did maintain large families, and demonstrate, from epigraphic data collected and presented in my dissertation, how foreign ethnic and religious identities were variously integrated into Roman military culture by both individual auxiliaries and the Roman state. The history of the auxilia in Germany from the time of Augustus and in Britain from the time of Claudius is discussed, with extensive reference to epigraphic material provided in appendices to this work. Analysis of military diplomas from across the Roman empire demonstrates a significant phenomenon of auxiliary family creation that helps to contextualize the diploma data from Germania and Britannia. Research on further epigraphic evidence from Germania and Britannia demonstrates a marked diversity in religious dedications by auxiliary soldiers and further evidence for auxiliary families. From a discussion of the history of the concept of ‘Romanization’ and other theoretical models that can be applied to the study of the auxilia, the continued usefulness of the evolving concept of ‘Romanization’ to our understanding of auxiliary cultural integration is assessed. Auxiliary service is shown to have provided many non-Roman ethnic groups avenues of cultural and legal inclusion that each soldier, surely in his own way, could exploit.

Keywords: Roman History
Roman Army
Romanization
Roman Family
Roman Religion
Military Diplomas
Advisor: Bruun, Christer
Edmondson, Jonathan
Asssessment of Tissue Viability in Acute Thermal Injuries Using Near Infrared Point Spectroscopy

Introduction: Currently, there are no objective techniques to assess burn depth. An early assessment of burn depth would enable accurate management decisions, which would improve patient outcomes. Near infrared (NIR) technology has shown promise as a non-invasive monitor of oxygenation and perfusion, and its potential to assess the depth of burn injuries has been investigated clinically over the past five years. The purpose of the thesis was to determine the capacity of NIR technology to differentiate acute thermal injuries. Methods: Burn sites (n=5) and control sites (n=5) were created on the dorsum of sixteen animals with brass rods held at constant pressure and heated to 100°C and 37.5°C respectively. NIR data was collected from the burns and control sites pre-burn, immediately post-burn, and 1, 12, 24, 36, 48 and 96 hours after the burn injury. Biopsies of the burn and control sites were acquired at each time point and used to confirm the depth of injury. NIR data was processed for the content of water, oxy-, deoxy- and methemoglobin. Results: Oxyhemoglobin and total hemoglobin decreased as burn depth increased. The proportion of oxy- and deoxyhemoglobin to total hemoglobin showed that the ratio of oxy- to deoxyhemoglobin decreased as burn injury increased. Methemoglobin levels as a ratio of total hemoglobin also showed that as the severity of injury increased the proportion of methemoglobin also increased. Finally, superficial partial thickness injuries (3 s and 12 s) showed early peak levels of water, which rapidly declined towards baseline. The deep partial thickness injuries (20 s and 30 s) do not experience peak levels and retain water over the course of the experiment. The full thickness injuries water levels remain close or below baseline levels throughout the experiment. Conclusion: NIR spectroscopy could distinguish burn depth using water, oxy-, met- and total hemoglobin as separate entities. The presence of methemoglobin in the burn wounds is a novel finding that has not been described previously in burn literature.

Keywords: Near Infrared Spectroscopy
Burn Depth
Advisor: Fish, Joel Steven