VictorJuiz/thesis huggingface dataset:
Effects of Dietary Pulses on Lipids and Oxidative Stress as Risk Factors of Cardiovascular Disease

The objective was to conduct a systematic review and meta-analysis of randomized feeding trials to assess the effect of dietary pulses (beans, chickpeas, lentils, peas) on established lipid targets of cardiovascular disease (CVD) and perform a secondary analysis of our randomized feeding trial to assess whether dietary pulses as a means of lowering the glycemic index offer further CVD protection by reducing oxidative stress. The meta-analysis of 26 trials (n=1013) found dietary pulse interventions significantly lowered LDL-C compared with isocaloric control interventions (mean difference=-0.17mmol/L [95% CI: -0.25, -0.09]; p<0.0001). No treatment effects were observed for Apo-B and non-HDL-C. Our feeding trial found no significant differences between the high-dietary pulse diet and high-fibre control diet on markers of oxidative stress, including thiobarbituric acid reactive substances (TBARS), conjugated dienes (CDs), and protein thiols. Overall, the results suggest dietary pulses reduce LDL-C but not oxidative stress as a means of reducing cardiovascular risk.

Keywords: Dietary Pulses
Lipids
Oxidative Stress
Cardiovascular Disease
Systematic Review
Meta-Analysis
Dietary Feeding Trial
Dyslipidemia
Dietary Guidelines
Advisor: Jenkins, David J. A.
Sievenpiper, John L.
The Cardiovascular Consequences of Recreational Hockey In Middle-aged Men

The present study examined the hemodynamic response to recreational hockey (n= 22) in middle-aged men (53±6 yrs). Study participants were equipped with ambulatory blood pressure and heart rate monitoring equipment prior to a weekly hockey games. Participants were monitored throughout the duration of their hockey game for “On-Ice” responses and during seated bench time (“Bench”), and for a brief period afterwards. On-Ice HR’s and blood pressures were significantly higher than values obtained during maximal cycle exercise (HR 174±8.9 vs. 163±11.0 bpm) (SBP 17%; DBP 15%) (p<0.05), Blood pressures decreased throughout the duration of the game while HR increased significantly. The On-Ice endocardial viability ratio (EVR), an index of myocardial oxygen supply and demand, did not change from early (1.56±0.05) to late (1.44± 0.06) in the game. In conclusion, recreational hockey is an extremely vigorous form of interval exercise that produces cardiovascular responses exceeding intensities commonly recommended for continuous training.

Keywords: Hockey
Cardiovascular
Blood Pressure
Maximal Exercise
Advisor: Thomas, Scott
Pulmonary Vascular Mechanics in Long-standing Male Endurance Athletes at Rest and During Exercise

This study examined right-ventricular-pulmonary arterial (RV-PA) coupling and pulmonary vascular mechanics during acute exercise in 12 middle-aged men with a long-standing history of endurance training. Subjects underwent simultaneous right-heart catheterization and echocardiography, with measures obtained at steady state heart rates of 100, 130 and 150 beats/min. Subjects were highly trained and displayed RV remodeling of endurance-trained athletes. During exercise at 100 beats/min, systolic, diastolic, and mean pulmonary artery pressure increased significantly from rest, as did pulmonary capillary wedge pressure. The slope of pooled mean pulmonary pressure indexed to cardiac output was 1.436 mmHg⋅min-1⋅L-1 with a distensibility index of 0.112 ± 0.048 mmHg-1. The pulmonary arterial elastance-RV end-systolic elastance ratio (Ea:Ees) decreased from rest to exercise at 130 beats/min (P < 0.01). These results suggest that Ea:Ees becomes favourable for RV function during exercise, indicative of a pulmonary vasculature that is highly distensible and well matched to RV output.

Keywords: Exercise
Ventricular-Arterial Coupling
Right Ventricle
Catheterization
Advisor: Goodman, Jack
Language, Power, and Race: A Comparative Approach to the Sociopolitics of English

This thesis highlights the sociopolitics of English as a dominant/colonial language by focusing on the linkage between language, power, and race. Grounded in critical language theory, comparative education theory, and anti-racism research methodology, this research examines the inextricable relationship between language, power, and race. With this in mind, this thesis argues that language, specifically English, is not a neutral tool of communication but a highly contentious issue that is deeply embedded in sociopolitical ideologies and practices. The contexts of Japan and Trinidad and Tobago are used to illustrate how colonialism continues to impact English language policy, practice, and perceptions. In sum, this research aims to bridge the gap between critical language theory, comparative education theory, and anti-racism studies in a way that (1) highlights the complexity of language politics, (2) explores ideological assumptions inherent in the discourse of the "native" language, and (3) underscores the overlooked ubiquity of race.

Keywords: Politics of Language
Race
Language Policy
Power
Japan
Trinidad and Tobago
Language Education
Education
Anti-racism research methodology
Language Politics
Language Production
Commodification of Language
Racialized Bodies and Language
Colonialism
English
International Communication
Education Policy
Language Ideology
Critical Language Theory
Comparative Theory
Sociopolitics of English
Auto-ethnography
Linguicide
Post-Colonialism
Indigenous Research Methodology
Advisor: Christine, Connelly
Beyond Bone Mineral Density: Detecting Changes in Fracture Risk in the Absence of Mineral Loss with the Mechanical Response Tissue Analyzer

The ability of current clinical tools to predict bone fractures is poor, likely because these tools focus on bone mass and mineral content and neglect bone quality and the collagen phase. The Mechanical Response Tissue Analyzer (MRTA) is an instrument that provides a non-invasive mechanical measurement of the whole bone. It has traditionally been used to obtain a bone stiffness constant (Kb), but can provide a bone damping constant (Bb) that has not previously been considered. The goal of this research is to determine whether the MRTA can detect three damage modes that do not alter bone mass or mineral density: γ-irradiation, collagen over-crosslinking, and fatigue. The MRTA detected a reduction in Bb due to over-crosslinking. Fatigue was found to increase Bb and decrease Kb, and these changes were confirmed through dynamic bending tests. The MRTA shows potential to diagnose increased fracture risk in scenarios where damage is currently undetectable.

Keywords: mechanical response tissue analyzer (MRTA)
fracture risk
bone collagen
bone fatigue
Advisor: Grynpas, Marc D.
Willett, Thomas
Decolonizing the Curriculum in Chile: A Critical Discourse Analysis of the Notion of Human Being and Citizenship as Presented in the Subject of History Geography and Social Science in the Elementary Level Curriculum

Through an analysis of History Geography and Social Science subject matter in the elementary level curriculum in Chile, this thesis highlights the role of official education in constructing a notion of human being that gravitates toward Whiteness. The law of education and the curriculum are analyzed to examine the way in which official curriculum operates as a mechanism for oppression, exclusion, and marginalization. It is argued that through the curriculum, a national ideology that incorporates a hegemonic notion of ideal human being and citizen is promoted. Using an anti-colonial, anti-racist discursive framework, and techniques from Critical Discourse Analysis, this work locates Chilean official education and curriculum as the culmination of colonial and racist notion of human and citizenship values supported by the neoliberal state. The researcher advocates for equity and justice in the education system that acknowledges Chile as a multicultural country where different ways of knowing coexist.

Keywords: Chilean official curriculum
Discourse Analysis
Advisor: Dei, George Jerry Sefa
Implications of Ambient Ammonia on Aerosol Acidity and Reactive Nitrogen Measurements

This study describes two projects involving recent research on atmospheric ammonia. The first project investigates differences in modelling techniques of aerosol acidity using data from two recent field campaigns. Our results show that allowing or disallowing gas-particle partitioning in the Extended Aerosol Inorganic Model (E-AIM) changed the average modelled aerosol activity of H+ from one campaign by seven orders of magnitude and that disallowing gas-particle partitioning may not accurately represent the chemical state of the aerosols. The second project investigates the interference of reduced nitrogen in commercial chemiluminescent nitrogen oxide monitors with molybdenum oxide catalytic converters. This phenomenon is strongly dependent on the temperature of the catalytic converter. Our results show these instruments can have high conversion efficiencies of gaseous NH3 and NH4+ salts to NO at typical reported converter temperatures, but conversion efficiency varies between instruments and may be the result of uncertainty in reported converter temperature.

Keywords: atmospheric chemistry
ammonia
NOx measurements
NOy
Chemiluminscence
interference
aerosol acidity
inorganic aerosol
Advisor: Murphy, Jennifer
Harmonic Models of Common Converter Topologies for Accurate Harmonic Analysis of Distribution Systems

Harmonic distortion in a power system can excite non-characteristic harmonics from converter interfaced loads and generators which can then propagate back into the system, exciting other harmonics in the system. In this thesis, a harmonic analysis tool is presented that is designed to perform high accuracy, computationally efficient, steady-state harmonic analysis of distribution systems when multiple converter interfaced loads and generators exist in the system. The harmonic analysis tool requires less detail and engineering time than PSCAD/EMTDC while offering reliable assessment of harmonic coupling problems that are not captured by existing frequency-domain harmonic analysis tools. To do this, 5 harmonic models of common power electronic converter topologies were developed and implemented into this tool. The harmonic models are shown to be highly accurate; when tested in an unbalanced system with even and odd harmonic distortion, the harmonic models showed a maximum error of less than 0.4% when compared to PSCAD/EMTDC.

Keywords: harmonic model
converter modelling
FCM
harmonic admittance matrix
harmonic analysis tool
harmonics
Advisor: Lehn, Peter W.
Mechanisms of Right-ventricular Dysfunction in a Rat Model of Chronic Neonatal Pulmonary Hypertension

Chronic neonatal pulmonary hypertension (PHT) frequently presents with rightventricular (RV) dysfunction. In neonatal rats exposed to chronic hypoxia, RV dysfunction is reversed by sustained rescue treatment with a Rho-kinase (ROCK) inhibitor – the caveat being systemic hypotension. We therefore examined the reversing effects of pulmonary-selective ROCK inhibition. Rat pups were exposed to air or hypoxia from birth for 21 days and received sustained rescue treatment with aerosolized Fasudil (81 mg/ml t.i.d for 15 min) or i.p. Y27632 (15 mg/kg b.i.d) from days 14-21. Inhaled Fasudil normalized pulmonary vascular resistance, and reversed pulmonary vascular remodeling but did not improve RV systolic function. Systemic, but not pulmonary-selective, ROCK inhibition attenuated increased RV ROCK activity. Our findings indicate that RV dysfunction in chronic hypoxic PHT is not merely a result of increased afterload, but rather may be due to increased activity of ROCK in the right ventricle.

Keywords: Pulmonary Hypertension
Hypoxia
Rat
Fasudil
Rho-kinase
Y27632
Vascular Remodeling
Right-ventricular Dysfunction
Advisor: Jankov, Robert
A Gold Mine of Information: Using Pharmaceutical Data Mining to Ensure Long-term Safety and Effectiveness of Pharmaceuticals

In an era of highly advertised blockbuster medicines, newly approved pharmaceuticals can pose a hazard to the public if not properly monitored following their approval. Drugs are only given to a limited number of healthy individuals during clinical trials, leaving significant questions as to the risks for the population at large. There are limited opportunities for assessment following the product’s introduction onto the market and adverse effects may not be detected. This paper argues that hurdles in tracking long-term safety and effectiveness can be partially remedied through the aggregation and analysis of information collected through pharmaceutical data mining. Pharmaceutical data mining is a process whereby private organizations compile extensive information on patients’ prescription histories, including: the drug prescribed, recommended dosage, and the patient’s subsequent history with the medication. The Canadian government should collect this information and analyze its meaning to better ensure the long-term safety and effectiveness of drugs.

Keywords: Law
Policy
Pharmaceutical Regulation
Advisor: Katz, Ariel
Effect of Helium Circulation on the Onset of Oscillatory Marangoni Convection in Liquid Bridges

A half-zone experimental set-up was used to study the effects of various liquid bridge and helium flow parameters on the onset of thermocapillary convection in silicone oil liquid bridges. Experiments confirmed that helium flow has a stabilizing effect, with the effect increasing with helium velocity. Furthermore, helium flow in the same direction as surface flow due to Marangoni convection had a more stabilizing effect than countercurrent flow. It was established that increasing helium temperature has a mixed effect, producing a less stable bridge at low helium flow rates, but a more stable flow pattern at higher helium flow rates. Finally, it was confirmed that decreasing the cold disk temperature results in a decrease in critical temperature difference.

Keywords: microgravity
marangoni
liquid bridge
thermocapillary
Advisor: Kawaji, Masahiro
Development and Application of Serum Assay to Monitor Response to Therapy and Predict for Relapse in Acute Myeloid Leukemia

The diagnosis and monitoring of AML relies predominantly on the identification of blast cells in the bone marrow and peripheral blood. While at the time of diagnosis the identification of leukemic cells is relatively easy, during remission the identification of small numbers of blasts is problematic. This is most evident by the fact that patients who achieve complete remission frequently relapse, despite pathologic examination indicating a marked reduction in leukemic cell burden. In this thesis I have explored the potential of using serum proteins secreted by leukemic cells as a means of monitoring disease in patients. To identify proteins that might be useful for monitoring, I took advantage of published gene expression arrays and looked into online bioinformatics databases. Using specific characteristics, I was able to identify approximately 107 candidate proteins secreted by AML cells. RT-PCR analysis and ELISA assays were performed to evaluate the variability of expressions and serum level differences of twelve different proteins in the list.

Keywords: assay development
response to therapy
relapse
minimal residual disease
acute myeloid leukemia
ELISA
multiplexing
serum assay
Advisor: Minden, Mark
Increasing the Daily Throughput of Echocardiogram Patients using Discrete Event Simulation

Appointment scheduling involves picking a strategy for sequencing patient appointments such that the wait time per patient is minimized and the idle time and overtime for the doctor are minimized. The goal of this project is to increase the number of scans per day at the echocardiogram clinic in the Hospital for Sick Children. The objectives were realized by performing simulations of the workflow of the echo clinic using simulation software. The simulation model did not precisely reflect the echo clinic, and the disparity was attributed to limitations in the simulation model. Nevertheless, the user accepted the model and six different policy change scenarios were explored. All six scenarios yielded significant increases in average scans per day per sonographer. Scenario IV, which eliminated the use of sonographer schedules, was recommended to be implemented due to ease of implementation and lack of negative effect on patient wait time and sonographer overtime.

Keywords: discrete event simulation
healthcare
throughput
Advisor: Carter, Michael W.
A Determination of the Accuracy of Cone Beam Computed Tomography and Digital Orthopantomography for the Determination of Bone Quantity in the Mandibular Ramus

Objective: The purpose of this study was to compare the accuracy of cone beam CT (CBCT) imaging with digital orthopantomograms for determining bone quantity in the mandibular ramus. Methods: Twenty-nine cadaveric mandibles marked bilaterally with three fiducial markers were imaged using both CBCT and digital orthopantomography. After sectioning, four cross sectional measurements were made on the specimens and on the CBCT images. Two corresponding linear measurements were made on the orthopantomograms. Statistical analysis was used to compare the CBCT and orthopantomogram measurements with measurements from the anatomic specimens. Results: CBCT measurements were found to significantly differ from those made on the anatomic specimens (P<0.05). Linear measurements from the orthopantomograms varied by 15.9 percent compared to the anatomic specimens. Conclusion: CBCT and orthopantomogram measurements were significantly different from those of the anatomic specimens suggesting inaccuracies in the radiographic technology or a lack of precision in landmark identification.

Keywords: Ramus Graft
CBCT
Orthopantomography
Advisor: Clokie, Cameron
Fabrication and Characterization of PLA, PHBV and Chitin Nanowhisker Blends, Composites and Foams for High Strength Structural Applications

Biobased polymers are a critical research topic as they may serve as replacement to traditional unsustainable petro-chemical polymers. It is vital to widen its range of applications by improving its physical and mechanical properties via light weighting and strength improvements. Light weighting can be accomplished by introducing foam morphology to the material while mechanical strength improvements can be achieved by inserting stiff filler material to the base polymer to form a composite. This study explores the physical, mechanical, thermal, rheological and morphological properties of blends, foams and composites between biobased PLA and PHBV matrix polymers and biobased chitin nanowhisker filler. It was found that foams produced from PLA and PHBV blends exhibits refined cellular morphology which leads to light weighting and good strength preservation while chitin nanowhiskers was determined to be a very effective filler for mechanical property improvements in both solid and porous materials.

Keywords: Chitin
nanocomposite
Advisor: Naguib, Hani E.
Perisaccadic Suppression of Motion: Temporal and Directional Properties

When the eye rotates, switching from one fixation point to another, the perception of motion is strongly suppressed and rarely perceived. During these quick ‘saccadic’ eye movements, other aspects of visual perception become suppressed or compressed as well, with certain effects being stronger or weaker along the plane of the saccade - such differences can help identify the underlying neuronal pathways, since some exhibit directional tuning (e.g. neurons projecting from primate V1 to middle temporal area (MT)), and others do not (e.g. relay neurons linking the superior colliculus to area MT). A briefly presented motion probe was placed at a number of points relative to saccade to plot sensitivity to motion along different planes and directions. The results suggest that saccadic motion is suppressed before the eye begins to move, and is applied evenly across planes and directions.

Keywords: Neuroscience
Vision
Saccades
Motion Perception
Saccadic Suppression
Advisor: Niemeier, Matthias
Rhodium and Palladium Catalysed Domino Reactions of Alkenyl Pyridines and Alkenyl Pyrazines

Domino catalysis is an ideal strategy in the synthesis of heterocyclic scaffolds, as multiple bonds can be formed under a single set of reaction conditions. In this work, we present the development of two novel domino processes which afford access to aza-analogues of the dihydrodibenzoxepine motif. Careful optimisation revealed that the Rh catalysed hydroarylation proceeds under mild conditions as compared to the C-O coupling. Furthermore, Pd was not required for the C-O bond formation when using alkenyl pyrazines as substrates. Variation of the substituents on both the heterocycle and on the boronic ester provided insight into the structural features required for successful domino reaction, and a stepwise protocol was developed for incompatible substrates. We have also developed the first multi-metal, multi-ligand domino reaction featuring both a chiral and achiral ligand in the same pot, still leading to an enantioenriched product.

Keywords: Rhodium
Palladium
Arylation
C-O Coupling
Domino Catalysis
Heterocycles
Multi-Catalytic Reactions
Advisor: Lautens, Mark
The Pore Structure of Indiana Limestone and Pink Dolomite for the Modeling of Carbon Dioxide in Geologic Carbonate Rock Formations

The primary objective was to predict the relative storage capacity of carbonate rocks relevant for carbon dioxide sequestration. To achieve this, a detailed pore scale characterization of model carbonate rocks, Indiana Limestone and Pink Dolomite, was conducted utilizing micro-computed tomography (microCT) data using pore network modeling and invasion percolation simulations. For the first time in literature, Pink Dolomite’s pore space characteristics were analyzed. A secondary objective was to compare thresholding techniques as applied to carbonates which exhibit dual porosity (porosity at multiple length scales). The analysis showed the sensitivity of existing methods to the thresholding technique, imaging method and material. Overall, the contributions of this work provide an assessment of two carbonates relevant for carbon capture and storage at the pore scale; and a preliminary assessment into thresholding dual porosity carbonates.

Keywords: carbon capture and storage
microsctructure
Indiana Limestone
Pink Dolomite
pore network modeling
carbonate rocks
micro-computed tomography
microCT
scanning electron microscopy
SEM
thresholding
microporosity
dual porosity
saline aquifer
Advisor: Bazylak, Aimy
MacLean, Heather L.
Advancing Reproductive Rights in a Religious World: A Comparative Survey of Reproductive Rights in Poland, Indonesia and Israel

This paper surveys the legal implications of religious doctrines at they relate to the universal acceptance of reproductive rights. While the use of human rights to advance reproductive health has gained momentum over the last several decades, the variance in arranging religion and state relations and the significant impact religious institutions have over the substantive rights to reproductive freedom in many parts of the world necessitates a break from considering reproductive rights as a strictly secular issue. Using Israel, Poland and Indonesia as examples, this paper will explain how an understanding of the doctrines underlying major world religions is a crucial step towards recognizing how reproductive rights and freedoms can be advanced in a world where laws and policies are informed by both the sacred and the secular.

Keywords: Reproductive Rights
Religion
Advisor: Weinrib, Lorraine