VictorJuiz/thesis huggingface dataset:
Understanding the Moral Nature of Intrapartum Nursing: Relationships, Identities and Values

The establishment of effective relationships is fundamental to good nursing practice and the fulfillment of nurses’ moral responsibilities. While intrapartum nurses are uniquely placed to establish relationships that can directly influence the woman’s experience of childbirth, there has been limited investigation of the relationships, identities and values that underlie nurses’ varied approaches and responses to labouring women. The purpose of this study was to explore intrapartum nurses’ understanding of their moral responsibilities from a social-moral perspective, using Margaret Urban Walker’s “expressive-collaborative” model of morality. Interviews were conducted with fourteen registered nurses working in a birthing unit of a Canadian teaching hospital. Four themes were identified that captured nurses’ moral responsibilities, including: organizing and coordinating care, responding to the unpredictable, recognizing limits of responsibilities to others, and negotiating care with women and families. Nurses enacted their moral responsibilities to labouring women in a variety of ways depending on their personal and professional experience, the circumstances, the people involved and the context of care. A key factor influencing responses to women was the degree to which understandings and expectations related to birth were deemed to be reasonable and mutually agreed upon among nurses, physicians, women and their families. Nurses also described limits on their responsibilities to others. Their choice of response to circumstances in which practice was constrained departed from the idealized expectations and ‘expert’ practices often reflected in professional guidelines. While nurses were able to identify contextual influences that constrained their ability to maintain effective relationships with women, the influence of their own values on the care they provided was less apparent. This suggests a need to challenge normative assumptions related to care of women in childbirth, including the provision of choice and family centred care, in order to create environments that can support and sustain practices that build understanding, mutuality and trust between nurses and birthing woman. In addition, given the contested nature of childbirth and the lack of shared understandings of what constitutes ‘best’ care, there is a need to develop collaborative models of inter-professional maternity care that include the voices of women as a central component.

Keywords: Intrapartum nursing, childbirth, choice, nursing ethics, moral responsibilities, narrative, Margaret Urban Walker
Advisor: Peter, Elizabeth Helen
Policing Poverty: Race, Space and the Fear of Crime after the Year of the Gun (2005) in Suburban Toronto

In 2005, firearm homicides in Toronto spiked to unprecedented levels, prompting mainstream media to label 2005 as the ‘Year of the Gun’. While the majority of those killed were young black men in Toronto’s impoverished post-war suburbs, the shooting death of a young white woman downtown reframed the problem of gun violence in popular and policy discourse from the perspective of those it least affected: the predominantly white middle-classes in the gentrified urban core. This dissertation attempts to situate dominant narratives of the problem of gun violence and policy responses to it as an event in a history of Toronto, especially with reference to transformations in urban space and governance. It argues that the Year of the Gun can be understood as a destabilizing moment in the city’s collective history that helped normalize ways of narrating and governing a growing socio-spatial divide between the city and the post-war suburbs. Through analyses of government proceedings, media discourse, social scientific research, participant observation, and key informant interviews it identifies how intersecting discourses, practices and representations framed racialized poverty and crime in ways that further solidified causal links between the two. It offers a history for these causal links, illustrating how race and space have long played a vital role in real and imagined divisions between the city and its suburbs. It explores the formation and administration of three policy approaches responding to the crisis: a municipal policy framework for social investment, a targeted policing strategy, and non-profit faith-based programs for young black men. It analyses how each defined social problems for government in ways that eclipsed broader processes generating social inequality in the city. The findings of this research suggest that dominant narratives and practices governing poverty and crime have prevented public discussions about the racialized architecture of neoliberal urbanism while enforcing one of suburban decline. They have prevented dialogue about the correlation between whiteness and wealth in the core, while enforcing causal relations between blackness, poverty and crime in the suburbs. And they have prevented critiques about the surveillance of the city’s young black men, while enforcing projections of these same men through the prism of masculinist culture.

Keywords: urban governance
Toronto
Advisor: Goonewardena, Kanishka
Role of Lipid Rafts in Enterohemorragic Escherichia coli 0157:H7 Mediated Hijacking of Host Cell Signalling Pathways to Induce Intestinal Injury

Enterohemorrhagic Escherichia coli O157:H7 (EHEC) is a human intestinal pathogen, which can cause severe disease. EHEC O157:H7 is responsible for outbreaks of diarrhea and hemorrhagic colitis. EHEC produces a potent cytotoxin known as Vero (Shiga-like) cytotoxin, which causes diarrhea-associated hemolytic uremic syndrome (HUS), the most common cause of acute renal failure in children. Current treatment remains predominantly supportive in nature because antibiotics and non-steroidal anti-inflammatory drugs exacerbate the condition. Therefore, alternative therapeutic approaches that will prevent the EHEC colonization without the release of toxins need to be delineated. Understanding the pathobiology of disease is likely to yield novel approaches to interrupt the infectious process. My hypothesis was that pathogen-derived effectors associate with lipid rafts and, thereby, promote the recruitment of host signal transduction proteins to lipid rafts in response to EHEC O157:H7 infection. In this thesis, specific host signalling pathways hijacked by EHEC O157:H7, through lipid raft signalling platforms, to elicit pathogenic effects are studied using complementary approaches, including epithelial model cell lines and an animal model of infection (Citrobacter rodentium challenge of mice). A lack of osteopontin resulted in decreased attaching effacing lesions and reduced colonic epithelial cell hyperplasia in response to C. rodentium infection. These findings suggest that C. rodentium, mimicking EHEC O157:H7 infection, is capable of utilizing host cell components to elicit its pathogenic effects. In vitro data showed that EHEC O157:H7 effector proteins manipulate cell signalling through lipid rafts employed as platforms to recruit and activate host second messengers. PKC and PI3K activation led to attaching and effacing lesions, disruption of tight junctions, and the initiation of both innate and adaptive host immune responses. The results pointed towards a role for atypical PKC in EHEC-induced attaching and effacing lesion formation. The role of lipid rafts in EHEC O157:H7 pathogenesis was also studied using Citrobacter rodentium-infected Niemann-pick type C (NPC) mice. Infection of NPC mice, which lack lipid rafts, with C. rodentium resulted in delayed colonization and delayed onset of attaching-effacing lesion formation, compared with infected wild type mice. C. rodentium-infected NPC mice also demonstrated reduced colonic epithelial hyperplasia and decreased secretion of the pro-inflammatory cytokine, interferon-γ. Taken together, the findings presented in this thesis highlight the importance of host cell signal transduction cascades in EHEC O157:H7 disease pathogenesis, and demonstrate a role for lipid rafts and OPN in mediating host cell signaling responses to non-invasive enteric microbial pathogens.

Keywords: Escherichia coli O157:H7
Lipid rafts
Advisor: Sherman, Philip M.
Staging Tudor Royalty: Religious Politics in Stuart Historical Drama (1603-1607)

Staging Tudor Royalty: Religious Politics in Stuart Historical Drama (1603–1607) examines the plays and pageantry about the Tudor royals in the context of three major events: the Hampton Court Conference (1604), the Anglo-Spanish Peace Negotiations (1603–1604) and the Gunpowder Plot (1605). Chapter 1 provides an historical survey of the political and legal controversies concerning religious belief and practice from Henry VIII’s creation of the royal supremacy (1533–1534) to Elizabeth’s final year as queen (1603). Chapters 2 through 5 comprise four case studies, each of which centres on a play or pageant about the Tudor royals and its relationship to one of the aforementioned events. Chapters 2 and 3 examine Thomas Heywood’s If You Knovv Not Me, You Know No Bodie (1604) and Samuel Rowley’s When You See Me, You Know Me (1604), dramatizations of Elizabeth’s years as princess and the later years of Henry VIII’s reign respectively, in light of the puritan campaigns for church reform and religious toleration surrounding the Hampton Court Conference. Chapter 4 examines the uses of the Tudors in Thomas Dekker’s The Magnificent Entertainment, a detailed account of James’s royal entry of March 1604. In particular, I focus on the London-Dutch community’s celebration of Tudor religious and economic commitments to the Protestant Low Countries in relation to the early Stuart negotiations for an end to the Anglo-Spanish war. Chapter 5 discusses Thomas Dekker’s allegorical rendering of the later decades of Elizabeth’s reign, The VVhore of Babylon (1607), as a commentary on the Stuart government’s response to Jesuit insurgency following the Gunpowder Plot. In order to situate these plays and pageants in their precise contexts, each of the four case studies incorporates a variety of historical evidence ranging from royal proclamations to religious polemics, from stories of martyrdom to state trials. This thesis offers a topical reading of play and pageantry in which the Tudor past engages with the seminal political-religious issues and controversies of early Stuart England.

Keywords: English
Advisor: Lancashire, Anne
Using Modeler Intent in Software Engineering

Models are used widely within software engineering and have been studied from many perspectives. A perspective that has received little attention is the role of modeler intent in modeling. Knowing the intent of the modeler supports both model comprehension by providing the correct context for interpreting the model and model quality by clearly defining what information the model must contain. Furthermore, formal expressions of this intent allow automated support for this. Despite the value that the knowledge of modeler intent can provide, there are no adequate means in the current state of modeling practice for expressing this information. The focus of this thesis is to address this gap by providing mechanisms for expressing modeler intent both explicitly and formally. We approach this problem by recognizing the existence of a role level in modeling where the role each model plays defines what information it should contain and how this is related to the information in other models. The specification of these roles is what we refer to as the expression of modeler intent. We then present a framework that incorporates four aspects of modeler intent at the role level: the existential intent for a model that arises in response to the need for a set of information by stakeholders, the content criteria that express what information the model is intended to contain, model relationships that express how models are intended to constrain one another and the decomposition criteria that express the intent behind how a model is decomposed into a collection of models. A key contribution of this thesis is the specification of the macromodeling language as a new modeling language designed for the role level that supports the expression of all four aspects of modeler intent. We evaluate these techniques by applying them to two real-world modeling examples.

Keywords: Modeling
Intention
Advisor: Mylopoulos, John
Easterbrook, Steve
The Fanconi Anaemia Protein D2 has an Essential Role in Telomere Maintenance in Cells that Utilize the Alternative Lengthening of Telomeres Pathway

Fanconi anaemia (FA) is an inherited disorder characterized by bone marrow failure, cancer predisposition and congenital abnormalities. The 12 known FA genes have been implicated in homologous recombination (HR), a process involved in telomere maintenance. A complex of at least 7 FA proteins promotes FANCD2 monoubiquitination and nuclear foci formation. FANCD2 colocalizes and interacts with HR proteins, however the role of FANCD2 in HR is unclear. Telomeres in dividing human somatic cells shorten until they reach a critical length, triggering most cells to undergo senescence or apoptosis. Rare immortal cells escape this crisis by expressing telomerase, or activating the Alternative Lengthening of Telomeres (ALT) pathway, which involves HR. FA core complex proteins and FANCD2 colocalize with telomeric foci in ALT, but not telomerase positive cells. Localization of FANCD2 to ALT telomeric foci requires monoubiquitination by the FA core complex, but is independent of ATM and ATR. FANCD2 primarily colocalizes with ALT telomeric DNA within ALT-associated PML bodies (APBs). Electron spectroscopic imaging and FISH experiments show that APBs contain extra-chromosomal telomeric repeat (ECTR) DNA that is non-nucleosomal. Depletion of FANCD2 causes marked increases in ECTR in ALT, but not telomerase positive cells. Overexpression of BLM, the helicase mutated in Bloom syndrome, also causes an ALT-specific increase in ECTR DNA. FANCD2 coimmunoprecipitates with BLM in ALT cells, and FANCD2 localization to ALT telomeric foci requires BLM expression. FANCD2-depleted ALT cells have reduced viability, signs of mitotic catastrophe, and multiple types of telomeric abnormalities, including increases in telomeric recombination, entanglements, colocalization with DNA repair proteins, and expression of fragile site characteristics. SiRNA depletion of FANCD2 does not cause overexpression of BLM, however codepletion of BLM with FANCD2 suppresses the telomere phenotypes caused by FANCD2 knockdown. Together this suggests that FANCD2 regulates BLM-dependent recombination and amplification of telomeric DNA within ALT cells.

Keywords: telomere
Fanconi anaemia
recombination
FANCD2
ALT
genomic instability
Advisor: Meyn, M. Stephen
Belief & Linguistic Agency

This dissertation consists in a defence of the claim that belief is a state on which its bearer can reflect only deliberatively. That partial characterization of the concept is intended to throw light on the status of belief as a rational phenomenon. I defend it by appeal to features of our actual and imagined practices of ascribing belief linguistically, both to others and ourselves. Having set out the characterization in the first of four chapters, in the second chapter I survey the ways of learning from words: evidentially, by report, and by belief-expression. I go on to propose that where a person’s words afford belief of his belief, they do so through the belief-expressive character of assertoric speech. In the third chapter, I defend that claim as it applies to the case of ascribing belief to another. I argue that my characterization best explains the fact that we do not ordinarily report our beliefs or invite others to do so. I explain our ordinarily ascribing belief from the expressive character of assertoric speech by appeal to the relation between assertion and belief. In the fourth chapter, I turn to the prospect of ascribing oneself belief based on one’s own words. I argue that self-ascribing belief through the expressive character of words is alone consistent with the self-ascriber’s basic psychological and linguistic integrity. I recommend my characterization of belief for its capacity to explain the disintegrating effects of self-ascribing belief by one’s own report. I again appeal to the relation between assertoric speech and belief to explain the feasibility of self-ascribing belief through the expressive character of one’s words.

Keywords: belief
rationality
reflection
ascription of mental states
linguistic agency
epistemic agency
testimony
knowledge of other minds
self-knowledge
Advisor: Franks, Paul
Socio-cultural Inclusiveness and Workplace E-learning: From Dominant Discourse to Democratized Discourses

Technological enhancements and economic gains are the dominant focus of normalized research of workplace e-learning programs. This is not, however, equivalent to discovering whether or not workers are actually experiencing any socially and culturally meaningful learning from workplace e-learning programs. This thesis advocates socio-cultural inclusiveness research on workplace e-learning programs. Socio-cultural inclusiveness research takes into account the learning needs of workers with respect to their various social differences and culturally unique identities that affect, mediate, and interpret workers’ learning. The intent is to transform perceptions of workplace e-learning programs, from technological artefact to ideational discourses. Discourse Analysis is applied as a socio-cultural approach to ten passages that have been extracted from ten examples of normalized research published over the past decade. This is done to explore whether a normalizing paradigm is noticeable and how such a normalizing paradigm might lead workplace e-learning programs to socially marginalize and culturally exclude workers. To discursively analyze the passages and identify a normalizing paradigm, this thesis applies ‘Discourse model’ as ‘tool of inquiry’. Discourse models reveal heuristic, taken-for-granted assumptions about what is socially normal and culturally representative in talk and text. The normalizing paradigm that does emerge from this cursory analysis, constructs normalized e-learning as the conflation three assumptions: technological proficiency; economic efficiency; and, training consistency. This normalizing paradigm socially justifies workers in the workplace through normalized e-learning. To promote democratized counter discourses, this thesis puts forward critical perspectives, taxonomies, and frameworks that enable praxis of socio-cultural inclusiveness research. This thesis relies on three critical perspectives to discursively resist three formal biases inherent in normalized e-learning that emerge from this normalizing paradigm. Using a critical pedagogy perspective, this thesis reflects on the formal bias of ‘standardization’ and its alignment with ‘training consistency’ to discuss ‘worker-worker’ alienation from ‘pedagogical standardization’. Taking a critical culture perspective, thesis hones in on the formal bias of ‘categorization’ and its alignment with ‘economic efficiency’ to elaborate ‘worker-work’ alienation from ‘cultural categorization’. With a critical history perspective, this thesis focuses on the formal bias of ‘operationalization’ and its alignment with ‘technological proficiency’ to expand on ‘worker-identity’ alienation from ‘ahistorical operationalization’.

Keywords: workplace
e-learning
adult
education
democracy
discourse
constructivism
socio-cultural
Advisor: Schugurensky, Daniel
The Effects of Impression-management Motivation on Eating Behavior in Women

Previous research suggests that the amount of food that women eat may fluctuate depending on their impression-management motivation; however, the results do not provide direct evidence supporting such an explanation. That is, no studies conducted to date have actually manipulated impression-management motivation and measured its effects on eating behavior. The present program of research aimed to confirm that eating behavior in women does, in fact, change as a result of impression-management motivation. Experiments 1, 2, and 3 tested this by manipulating impression-management motivation via direct and explicit instructions. Experiment 3 was also designed to investigate how impression-management motivation might affect eating in situations in which females are eating with a friend (as opposed to a stranger). The results demonstrate that women motivated to make a good impression on a male stranger (Experiments 1 & 2) and a female stranger (Experiments 2 & 3) eat less than do those for whom the desire to make a positive impression has been disrupted. The results also confirm previous findings showing that women eat less when eating with a male stranger than when eating with a female stranger (Experiments 1 & 2). The findings from Experiment 3 suggest that there may be a different pattern of eating associated with impression-management motivation when women eat with female friends; it was found that participants ate more with a friend when they were motivated to make a good impression compared to when this motive was not present. These results may be explained by impression-management theory, in combination with notions about the complexity of female friendships and female-female competition surrounding eating, dieting, weight, and appearance.

Keywords: Psychology
Impression management
Self-Presentation
Eating
Women
Social influence
Advisor: Pliner, Patricia
Considering Adoption: How are Innovations Validated in Cultural and Science-based Industries?

This thesis examines the process by which innovative new products come to be accepted and adopted in the marketplace. As these products are inherently uncertain and not readily accepted and adopted, market intermediaries play an important role in the validation and subsequent diffusion of innovations. In this thesis I demonstrate that these social processes have significant impact on the spatial organization of the market development process. Drawing on a diverse but complementary set of literatures – including the economic geography of innovation, communities of practice, social networks, the sociology of scientific knowledge and reception studies – I sketch out an adoption-centric approach to understanding the social dynamics of the innovation process. Using comparative case studies of musical theatre and pharmaceutical vaccines, this research finds that the process of market development involves a range of participants that are each embedded in their own distinctive community. The social and geographic configuration of these intermediaries varies for different knowledge-intensive products: validating expertise for cultural products such as theatre is situated predominantly in ‘global nodes of excellence’, whereas for science-based goods such as vaccines this is situated in the local marketplace. These findings have implications for marketplaces in ‘beta-cities’ such as Toronto, which are not global nodes of excellence. Without these validating intermediaries, what role do beta cities play in the development and diffusion of cultural products? Akin to research on users’ involvement in the development of innovations, findings suggest there are qualities that make beta cities important sites for experimentation and the testing of new theatrical works. An adoption-centric perspective such as the one developed in this thesis sheds light on the social and geographic forces that shape the uptake of innovations. Application of this perspective has potential to significantly strengthen policy initiatives in support of the demand-side of regional innovation systems.

Keywords: Economic Geography
Innovation
Advisor: Gertler, Meric S.