VictorJuiz/thesis huggingface dataset:
Corporations and Rawlsian justice

Corporations – their power and impact on society – are a neglected topic in political philosophy. In this thesis, I attempt to address this neglect by using the framework of Rawlsian justice to examine what corporations' relationship to social and international justice ought to be. The first part of the thesis is on domestic social justice. I urge that Rawlsians should not begin their inquiry by taking the corporate form as given because the corporation's existence requires a specific set of private-ordering and property rules to be in place. What we should ask, instead, is whether these rules are actually permitted by the two principles of justice as fairness. This question leads to an examination of different economic regimes that are compatible with Rawlsian justice. I focus on one particular regime – that of property-owning democracy. What I find is that while not all versions of property-owning democracy would permit the corporate form, some would actually welcome it due to the feature of 'the separation of ownership and control' that is typical of modern corporations. The second part of the thesis is on international justice. I argue that the best way to situate corporations in Rawls's theory of international justice – his Law of Peoples – is to connect them to the duty of assistance. This is not a straightforward task because a relatively strict reading of the duty of assistance would disallow treating corporations as primarily responsible for discharging it. However, a revisionist approach to the Law of Peoples shows that we can understand the duty of assistance as a part of transitional justice. The significance of this is that Rawls's prescribed ideal theory of international justice does not determine who the agents for transitional justice ought to be or the grounds for attributing responsibility to such agents. We are thus free to adopt David Miller's criteria for attribution of remedial responsibilities to assign to corporations responsibilities for the duty of assistance. What is more, in a particular area of international justice – that of fairness in trade – we can establish that corporations can be primary agents of transitional justice.

Keywords: Rawls, John, 1921-2002
Property-Owning Democracy
Law of Peoples
Advisor: Miller, D
Identification of recruited myeloid cells important for the development of hepatic metastasis

Hepatic metastases are a frequent cause of mortality in colon cancer patients. Many patients with hepatic metastasis have large tumour burden, signaling the need for therapies capable of down-staging metastatic disease. Research evidence indicates that immune cells promote the metastasis of various primary cancers. We wish to determine whether immune cells play a role in the promotion of hepatic colon cancer metastasis.
Using the well-characterised method of intrasplenic tumour cell injection, we developed hepatic metastases in both immunocompetent and immunoincompetent mice using a range of murine and human cancer cell lines. We analysed the immune cell infiltrates associated with hepatic metastases using flow cytometry and identified chemokines responsible for their recruitment using targeted protein arrays. The effect of immune cell depletion or inhibition of immune cell recruitment was determined using various in-vivo imaging techniques.
Hepatic metastases developed using the murine colon cancer cell line MC38 were associated with CD11b+/Gr1mid/CCR2+ monocytes, the recruitment of which was delayed by inhibition of tumour-derived CCL2. In contrast, human HT29, HCT-116 and LoVo hepatic metastases in SCID mice were associated with infiltrates of CD45+/CXCR2+ neutrophils recruited in response to tumour-derived Macrophage Inhibitory Factor (MIF). Depletion of Gr1mid cells in CD11b-DTR transgenic mice delayed MC38 metastasis development, whilst neutrophil depletion using anti-Ly6G antibodies significantly inhibited the growth of HT29, HCT-116 and LoVo hepatic metastases. The neutrophils recruited to HT29, HCT-116 and LoVo hepatic metastases promoted angiogenesis, potentially through the expression of fibtroblast growth factor-2. This work demonstrates a role for myeloid cells in the development of hepatic metastasis from colon cancer and in doing so identifies various potential therapeutic targets.

Keywords: colon cancer
Advisor: Muschel, R
Changes in connectivity, structure and function following damage to the primary visual cortex

Residual vision, or blindsight, following damage to the primary visual cortex was first identified almost a century ago. However, the mechanism and pathways underlying this ability, as well as the extent of visual function, remain unclear and are a continuing source of speculation. The work presented here goes some way to try to address these questions, investigating 18 patients with V1 damage and homonymous visual field loss acquired in adulthood. Six experimental chapters explore the extent and potential for visual function after V1 damage, and apply novel neuroimaging paradigms and techniques to try to uncover the mechanisms and pathways that might be involved.
A combination of psychophysics, functional and structural MRI was used to investigate responses to blind field stimulation in the dorsal and ventral streams. In addition, diffusion MRI tractography was performed and related to psychophysical performance, so that the three main pathways implicated in blindsight could be evaluated. Lastly, a small rehabilitation study was carried out to assess the effect of training in the blind hemifield, and to investigate whether there is any transfer of learning between the dorsal and ventral visual streams.
The results from this work reinforce the suggestion that blindsight may be more common than was first thought, and may extend across a number of characteristics involving both visual streams. It is also suggested that visual function need not be completely unconscious, but that certain salient stimuli can elicit both non-visual and crude visual experience. The use of parametric functional imaging paradigms has enabled a number of properties of non-striate inputs to the extrastriate cortex to be revealed. Together with tractography, this points to an important role for the ipsilateral lateral geniculate nucleus in blindsight function. It is hoped that future work will build upon this, and that it may be possible to target these residual pathways in the rehabilitation of patients with V1 damage.

Advisor: Bridge, H
Kennard, C
An exploratory study of the educational processes of the PhD

There has been a significant increase in the numbers of students undertaking doctoral study over the last 20-30 years. This means that the PhD is no longer solely an elite degree designed to prepare graduates for an academic career. Instead, emphasis has increasingly been placed on the role of the PhD in producing 'advanced knowledge workers' who are expected to make a contribution to the production of knowledge in a knowledge-driven economy. This has led to an increased focus on the educational dimension of the PhD and the educational processes involved in developing students to become researchers in a range of contexts.
However, the educational processes involved in the PhD are complex and differ across higher education systems, institutions and disciplines. They include formal and informal activities and involve a large number of actors with different expectations about the aims and outcomes. This study aims to gain an in-depth understanding of the educational processes of the PhD by exploring the complexity underlying these processes.
The research was based on case studies in six departments. The case studies focused on the PhD processes of the six departments from three disciplines in four higher education institutions in England. Interviews with PhD Programme Directors, supervisors and students were complemented by analysis of institutional and departmental documents. The research was guided by a multi-level framework to examine the institutional, departmental, interpersonal and individual levels, and the inter-relatedness between levels. As such rich narratives provide insight into factors such as the PhD thesis and its influence on the supervisory relationship, formal initiatives such as assessment and coursework, and the Skills Training Programme and its underlying notion of employability.
Three forms of complexity were identified. The first relates to the fact that the educational processes are individualistic in nature, and there is a need to understand the influences of the personal, social, educational and professional domains of the individual students and supervisors independently and collectively in shaping these complex processes. The second underlines the tensions and potential contradictions within and between actors as a result of the interpretation and implementation of these processes across the four levels. The third concerns a tension between the need for these processes to remain individualistic and the pressure for departments and institutions to provide standardised processes for all students.
By identifying and gaining a greater understanding of these complexities, this research contributes to a more comprehensive understanding of the educational processes of the PhD based on grounded empirical evidence. This understanding is important in developments for enhancing the quality of PhD education, and in developing programmes which support students to become researchers in a range of different employment contexts.

Keywords: Educational Processes
Complexity
Doctoral Education
Advisor: James, S
Lunt, I
Food insecurity in American suburbs : lived experiences in the Bonney Lake area, Washington, USA

Suburban spaces within the United States have been subject to change over the past 50 years, in part because of the suburbanization of poverty. Suburban poor live within a policy blindspot. As result, increasing poverty within these areas has not received deserved attentions, leaving their challenges unaddressed. This thesis will use a case study of the Bonney Lake area in Washington, USA, to discuss challenges associated with living in suburban space and suburban poverty on issues of suburban food security. This will involve examination of shopping practice and motivations, in addition to issues of accessibility, choice, and affordability within the area, including the use of efficiency and nutrition shopping practice, influences of culture’s entanglement with familiarity, influences of the management effect, and the use of thrift, treats, and self-sacrifice. It finds time and transportation to be two important factors of food security within the Bonney Lake area.

Advisor: Hobson, K
Development of a spray process for manufacturing carbon nanotube films

This dissertation describes the development of a processing route for fabricating conventional and doped multi-wall carbon nanotube (MWCNT)/polymer composite films for dielectric applications. Previous research has shown that such composites are promising dielectric materials, but their commercial development has been impeded by the nanotube agglomeration in the polymer matrix and the inefficiency in forming uniform films. Moreover, the harsh fabrication treatments often disrupt the structure of the nanotubes, hence damaging their inherent electrical properties. This work presents safer routes for forming non-aqueous, surfactant free dispersions of conventional and doped MWCNTs, which can be readily mixed with polymers and formed into films through aerosol spraying.
Dispersibility behaviour of in-house synthesised conventional, nitrogen doped (N-MWCNTs), and boron doped (B-MWCNTs) MWCNTs was studied in 22 organic solvents. Based on thermodynamic theories it was suggested that doping, in particular nitrogen doping, significantly reduced the surface energy of the nanotubes. This aspect was crucial to understand the dispersibility of N-MWCNTs in low surface energy solvents and to achieve dispersions with high nanotube concentrations (0.82 mg/ml). Also, a "destruction reduced sonication protocol" involving mild sonication was suggested for forming MWCNT dispersions in organic solvents. Dispersions formed using this protocol were homogeneous and showed high stability of at least 2.5 years. Furthermore, the effect of ultrasonic probes on MWCNT lengths was studied and a decrease of 96–99% for MWCNTs and 85–95% for N-MWCNTs was observed. A numerical value for the nanotube length decrease during sonication has been reported for the first time.
Preliminary studies to generate dielectric films of MWCNT/perfluoro alkoxy polymer were performed using aerosol spraying. An improvement in the dielectric constant (3.56) with a low dissipation factor (0.003) was observed in 0.3 wt.% B- MWCNT/PFA composite films. Consistency in the test results from various parts of the films confirmed the uniformity of the nanotube distribution within the composite. Future work should concentrate on the effects of B-MWCNTs and N-MWCNTs at the percolation threshold due to their inherent electric properties.

Keywords: CNT Dispersions
Multi walled carbon nanotubes
Doped multi walled carbon nanotubes
Composites
Dielectrics
Capacitors
Advisor: Grobert, N
Ice-ocean interactions in north west Greenland

Ice shelves play an important role in the mass balance of an ice sheet, by providing a link between the ocean and ice. Melting at the base of an ice shelf can play a vital role in its mass balance and stability. Topographic channel features have been found on the base of ice shelves, and have been found to alter melting, however the mechanism behind this alteration is unknown. Petermann Glacier is a major outlet glacier in North West Greenland, draining approximately 6% of Greenland Ice Sheet. It terminates in a long, thin ice shelf, constrained within a high-walled fjord. The ice shelf has pronounced longitudinal channel features on its base, which limited observations suggest direct ocean currents in a mixed layer of ocean and melt waters, focusing melt in these regions. Petermann Glacier underwent two large calving events in 2010 and 2012, and the impact of these events, or possible further calving events, on basal melting is unknown.
Using the MITgcm to model the ocean cavity beneath an idealised ice shelf, this thesis discusses the impact of basal channels on interactions at the ice base and circulation within the cavity. This is supplemented with a modelling investigation into the interactions beneath Petermann Glacier, and the impact of recent calving events. The inclusion of channels was found to have a stabilising effect on the ice shelf by decreasing the mean basal melt rate, caused by the refocusing, and decrease in intensity of, the meltwater layer flow beneath the ice shelf. This stabilisation and resulting 'survivor bias' explains why channels are commonly found on the base of warm water ice shelves. The model of Petermann Glacier found similar melt patterns to observational studies, however with a lesser magnitude. The calving events of 2010 and 2012 removed areas of ice shelf with low melt rates, resulting in little impact on the overall volume of ice removed through ocean melting, though further calving would vastly reduce the volume of ice melted. One consequence of calving is the increase in melting-induced undercutting at the ice front, leading to the potential for enhanced secondary calving.

Advisor: Holland, P
Johnson, H
Jenkins, A
Essays on two-sector matching, status rewards and liability

This thesis consists of three self-contained chapters.
Chapter 1 develops a two-sector, bivariate matching model, in which each sector uses a different dimension of skill in the production process. I show there exists a unique assignment of agents to sectors and derive comparative statics. The main result is that if jobs are scarce, both an increase in sector one skills' spread and a technological improvement increase the supply of talent in sector one, but decrease it in sector two. In sector two, this raises wages and wage inequality. In sector one, the effects are ambiguous in general, but wages increase for the most and decrease for the least talented agents.
Chapter 2 studies the impact of social status on occupational sorting in a two-sector matching framework. Talent is two-dimensional and thus status is not a zero-sum game; it depends both on occupational prestige and within-sector rank (local status). I show that the weights with which these two components enter -- the structure of status -- crucially influence the way in which agents self-select into sectors and argue that it is likely that these weights differ across occupations. The more important are the individual components of status in a sector, or the less important the collective component, the better the agents who join that industry, which has important implications for total payoffs, wage levels and inequality, and profits. I also show that the stable assignment is typically inefficient, which is driven by the distortion of relative status rewards, not status concerns per se.
Chapter 3 investigates whether directors of companies should have limited liability. I develop a three-player model in which: (a) debtholders and equityholders are defined by their control rights and (b) the project is run by the directors. The main result is that increased liability for directors forces them to internalise more of the downside risk of the project and hence reduces their risk-taking. This is optimal if over-investment was a problem initially. I show that the extent to which over-investment is a problem depends on how well debtholders are protected compared to equityholders. If debtholders are strong, increased liability can cause under-investment.

Keywords: Social Status
Matching
Occupational Sorting
Advisor: Jewitt, I
The role of alpha-synuclein oligomers in Parkinson's disease pathophysiology and biology

Accumulating evidence links oligomeric species of the protein alpha-synuclein to the neuronal death associated with Parkinson's disease. However, the direct detection of alpha-synuclein oligomers in post-mortem brain has been challenging and this has limited our understanding of their structure, distribution and effects in Parkinson's disease.
The work presented in this thesis addresses two aspects of the role of alpha-synuclein oligomers in Parkinson's disease. Firstly, I describe the development of a novel technique, the alpha-synuclein proximity ligation assay (AS-PLA), which specifically detected alpha-synuclein oligomers in vitro and in post-mortem brain tissue. In a blinded study with post-mortem brain tissue from eight Parkinson's disease patients and eight controls, AS-PLA revealed widespread, previously unrecognised pathology in the form of extensive diffuse deposition of alpha-synuclein oligomers. Furthermore, AS-PLA preferentially detected early-stage, loosely compacted Parkinson's disease lesions such as pale bodies, whereas Lewy bodies, considered heavily compacted late lesions were only very exceptionally stained. The oligomeric species detected by AS-PLA displayed a unique, intermediate proteinase K resistance profile, suggesting the detection of a conformer that is different from both physiological pre-synaptic alpha-synuclein (proteinase K sensitive) and highly aggregated alpha-synuclein within Lewy bodies (proteinase K resistant). In addition, AS-PLA revealed the age-dependent accumulation of alpha-synuclein oligomers in the substantia nigra of a BAC transgenic mouse model of Parkinson's disease that overexpresses human wild-type alpha-synuclein, SNCA-OVX.
Secondly, the detection of early pathology in Parkinson's disease brain tissue using AS-PLA suggests that oligomeric species of alpha-synuclein could represent a potential target for therapeutic intervention. Therefore, I undertook a screen to identify compounds that can prevent the formation of alpha-synuclein oligomers in vitro. Using bimolecular fluorescence complementation constructs, I identified nine compounds capable of reducing the fluorescence indicative of the formation of alpha-synuclein oligomers. Two of these compounds showed dose-dependent activity. Future work will confirm the hits in vitro before studying whether Parkinson's-like phenotypes in the SNCA-OVX mice can be ameliorated or reversed by treatment with the compounds.

Keywords: Parkinson's disease
Pathology
Alpha-synuclein
Drug screen
Oligomers
Advisor: Abarrategui, J
Wade-Martins, R
Early microlithic technologies and behavioural variability in southern Africa and South Asia

Microlith production is a distinctive and significant stone tool technology. However, inter-regional comparative analyses of microlithic industries are rare, and have tended to homogenise these industries by focussing analytical attention on retouched tool typologies alone. This thesis provides the first demonstration and exploration of variability in two of the earliest microlithic industries in the world – the Howiesons Poort of southern Africa and the Late Palaeolithic of South Asia. Analysis of this variation has implications for the long-standing debates concerning modern human behaviour and dispersals.
In order to assess variability in underlying technological processes and manufacturing trajectories, detailed attribute analyses were conducted on lithic assemblages. Metric and qualitative variables were recorded on cores, debitage and tools from three southern African Howiesons Poort sites (Rose Cottage Cave and Umhlatuzana, South Africa, and Ntloana Tsoana, Lesotho) and four South Asian Late Palaeolithic sites (Batadomba-lena and Kitulgala Beli-lena, Sri Lanka, and Patne and Jwalapuram 9, India).
Analysis of the results reveals variability within sites, over time, and between sites and regions, demonstrating that microlith production is not a homogenous technology. Underlying technological processes are shown to differ more between regions than do retouched tool forms. It is argued that this pattern is more parsimoniously explained by independent innovation of microlithic technology situated within local lithic traditions, rather than by cultural diffusion. Additionally, the exploration of variability in microlithic assemblages highlights the benefits of using a methodological approach to the modern human behaviour debate which focusses on technological variability rather than the presence of particular tool types. It is this behavioural and technological variability that is key to understanding our species.

Keywords: Microlith
Howiesons Poort
Palaeolithic
Lithic technology