VictorJuiz/thesis huggingface dataset:
Useful Transcriptions of Webcast Lectures

Webcasts are an emerging technology enabled by the expanding availability and capacity of the World Wide Web. This has led to an increase in the number of lectures and academic presentations being broadcast over the Internet. Ideally, repositories of such webcasts would be used in the same manner as libraries: users could search for, retrieve, or browse through textual information. However, one major obstacle prevents webcast archives from becoming the digital equivalent of traditional libraries: information is mainly transmitted and stored in spoken form. Despite voice being currently present in all webcasts, users do not benefit from it beyond simple playback. My goal has been to exploit this information-rich resource and improve webcast users' experience in browsing and searching for specific information. I achieve this by combining research in Human-Computer Interaction and Automatic Speech Recognition that would ultimately see text transcripts of lectures being integrated into webcast archives. In this dissertation, I show that the usefulness of automatically-generated transcripts of webcast lectures can be improved by speech recognition techniques specifically addressed at increasing the accuracy of webcast transcriptions, and the development of an interactive collaborative interface that facilitates users' contributions to machine-generated transcripts. I first investigate the user needs for transcription accuracy in webcast archives and show that users' performance and transcript quality perception is affected by the Word Error Rate (WER). A WER equal to or less than 25% is acceptable for use in webcast archives. As current Automatic Speech Recognition (ASR) systems can only deliver, in realistic lecture conditions, WERs of around 45-50%, I propose and evaluate a webcast system extension that engages users to collaborate in a wiki manner on editing imperfect ASR transcripts. My research on ASR focuses on reducing the WER for lectures by making use of available external knowledge sources, such as documents on the World Wide Web and lecture slides, to better model the conversational and the topic-specific styles of lectures. I show that this approach results in relative WER reductions of 11%. Further ASR improvements are proposed that combine the research on language modelling with aspects of collaborative transcript editing. Extracting information about the most frequent ASR errors from user-edited partial transcripts, and attempting to correct such errors when they occur in the remaining transcripts, can lead to an additional 10 to 18% relative reduction in lecture WER.

Keywords: human-computer interaction
automatic speech recognition
computer supported cooperative work
Advisor: Baecker, Ronald
Penn, Gerald
The Potential of Optical Coherence Tomography for Intravascular Imaging of Chronic Total Occlusions

This thesis presents the first work, to our knowledge, to evaluate the potential of Optical Coherence Tomography (OCT) as an intravascular imaging modality to characterize and guide interventions on chronic total occlusions (CTOs) in arteries. An ex vivo imaging study using OCT is presented that characterizes various pathologies associated with peripheral CTOs and illustrates the ability to differentiate between the vessel wall and the occluded lumen. We also found that, while OCT could image approximately 1mm through tissue, it was effective for imaging deeper through clarified microchannels seen within the occluded lumen. While others had reported observing such microchannels within the lumen before, little was known about the global architecture of these channels. This motivated a study of the global morphology of microchannels in occlusions using micro computed tomography (microCT). In this microCT study, we found that microchannels within the occluded lumen of the artery appeared to be continuous over several millimeters. However, these channels also exited the artery frequently, suggesting the need for some form of imaging guidance. As a potential intravascular imaging set-up, a forward-viewing OCT catheter was built. This catheter uses a novel scanning mechanism that combines high voltage and a dissipative polymer to achieve fast compact actuation. Doppler OCT results are presented using this catheter to image flow in the forward direction. Doppler OCT imaging of microchannels in vivo is also shown in a surgically exposed occluded artery in situ.

Keywords: Optical Coherence Tomography
Chronic Total Occlusions
Interventional Cardiology
Intravascular Imaging
Vascular Disease
Image Guided Interventions
Advisor: Vitkin, Alex
Wright, Graham
Imagining the Internet and Making it Governable: Canadian Law and Regulation

This dissertation builds upon the existing body of criminological and socio-legal literature on Internet governance by looking at how this technology and its use are regulated in Canada. Rather than focusing on the regulation of specific web-based activities (e.g., illegal downloading, child luring, etc.) or the control of certain types of online content (e.g., hate speech, pornography, etc.), the dissertation considers the ways that regulatory bodies have responded to the emergence of this new medium. Three specific agencies involved in the governing of the Internet are studied in detail: The Canadian Radio-television and Telecommunications Commission (CRTC), the Media Awareness Network (MNet) and the courts. Using a variety of theoretical and conceptual tools taken from both governmentality studies and Actor-Network Theory (ANT), the dissertation empirically documents how these agencies imagine the Internet and make it governable. Instead of searching for global accounts that look to either Society or Technology as a source of explanation for why the technology is governed in a particular fashion, this project examines how certain knowledges about the Internet and its regulation get produced in the first place. Attention is paid here to how these agencies initially problematize the Internet, the kinds of regulatory strategies and practices that have emerged and the general impact this has had for our understanding of the Internet and the way in which it should be governed. In keeping with the constructivist tradition in the field of Science and Technology Studies (S&TS), the dissertation approaches the regulation of the Internet as a site where the very nature of this technology – in terms of what it does, how it can be used and whether or not it can or should be regulated – gets invented and reinvented. However, rather than bracketing the building of the Internet from its governance, these processes are seen as mutually constitutive whereby the technology must be made governable in order to be governed. Consequently, given the many different and often competing visions about the Internet, the version that gets accepted (at least, momentarily) is shown to be crucial for how the technology is eventually received.

Keywords: internet
regulation
governance
actor network theory
ANT
science and technology studies
S&TS
Advisor: Valverde, Mariana
Synthesis, Dynamics and Photophysics of Nanoscale Systems

The emerging field of nanotechnology, which spans diverse areas such as nanoelectronics, medicine, chemical and pharmaceutical industries, biotechnology and computation, focuses on the development of devices whose improved performance is based on the utilization of self-assembled nanoscale components exhibiting unique properties owing to their miniaturized dimensions. The first phase in the conception of such multifunctional devices based on integrated technologies requires the study of basic principles behind the functional mechanism of nanoscale components, which could originate from individual nanoobjects or result as a collective behaviour of miniaturized unit structures. The comprehensive studies presented in this thesis encompass the mechanical, dynamical and photophysical aspects of three nanoscale systems. A newly developed europium sulfide nanocrystalline material is introduced. Advances in synthetic methods allowed for shape control of surface-functionalized EuS nanocrystals and the fabrication of multifunctional EuS-CdSe hybrid particles, whose unique structural and optical properties hold promise as useful attributes of integrated materials in developing technologies. A comprehensive study based on a new class of multifunctional nanomaterials, derived from the basic unit of barcoded metal nanorods is presented. Their chemical composition affords them the ability to undergo autonomous motion in the presence of a suitable fuel. The nature of their chemically powered self-propulsion locomotion was investigated, and plausible mechanisms for various motility modes were presented. Furthermore functionalization of striped metallic nanorods has been realized through the incorporation of chemically controlled flexible hinges displaying bendable properties. The structural aspect of the light harvesting machinery of a photosynthetic cryptophyte alga, Rhodomonas CS24, and the mobility of the antenna protein, PE545, in vivo were investigated. Information obtained through a combination of steady-state and time-resolved spectroscopy in conjunction with quantum chemical calculations aided in the elucidation of the dynamics and the mechanism of light harvesting in the multichromophoric phycobiliprotein phycocyanin PC645 in vitro. Investigation of the light-harvesting efficiency and optimization of energy transfer with respect to the structural organization of light-harvesting chromophores on the nanoscale, can provide us with fundamental information necessary for the development of synthetic light-harvesting devices capable of mimicking the efficiency of the natural system.

Keywords: nanocrystals
europium sulfide
nanomaterials
nanomotors
energy transfer
light harvesting
Advisor: Scholes, Gregory D.
Ozin, Geoffrey Alan
“It’s All About War: Canadian Opinion and the Canadian Approach to International Relations, 1935-1939.”

Heather Metcalfe Doctoral Abstract, Ph.D. program, 2009 Department of History, University of Toronto “It’s All About War: Canadian Opinion and the Canadian Approach to International Relations, 1935-1939.” Canadians in the 1930s did not appear eager to focus on foreign affairs. The social and economic difficulties caused by the dislocation of the Great Depression meant that international developments often seemed remote and irrelevant. However, despite this focus on domestic issues, many Canadians were concerned with the trend of international events. As a result, the debate regarding the appropriate Canadian response remained an ongoing, if underlying, factor. In addition, the political issues raised by Canadian foreign policy, particularly through the Canadian involvement in the British Commonwealth and the League of Nations, meant the issue could not simply be ignored. During the later part of the decade, as the possibility of international conflict became ever more likely, increasing numbers of Canadians turned their attention to Canada’s international role. They also turned their attention to what this debate meant in terms of the Canadian sense of identity. These individuals were concerned as well with the response of Canadian public opinion to involvement overseas. This question, of the nature and susceptibility of Canadian public opinion to attempts to direct it, remains an intriguing one. The nature of this response remained open to question, and was the subject of significant debate among Canadian intellectuals, politicians and public figures. In response, a number of individuals and groups, including members of the Canadian press, attempted to influence Canadian public opinion. Many also pressured the Canadian government, led by William Lyon Mackenzie King’s administration, to play a more active role in shaping public opinion. Canadian intellectuals, for instance, influenced by contemporary writings on public opinion, seemed convinced of their natural role as ‘shapers’ of public opinion, particularly in a time of domestic and international crisis. These assumptions, and the ways in which Canadian public opinion both responded to, and rejected these attempts at direction, provide an interesting window into the question of public opinion, particularly in regards to international events. The debate regarding the Canadian response to the crises of the late 1930s can thus aid in gaining a greater appreciation of how public opinion shifts in response to outside challenges and the attempts to influence its course.

Keywords: Canadian Foreign Policy
Canadian Sense of Identity
Canadian Public Opinion
National Unity
Canadian Imperialism
Interwar Period
Canadian-American Relations
Second World War
Royal Tour of 1939
Intellectuals in Canada
Advisor: Bothwell, Robert
The Role of ATM in Promoting Normal T cell Development and Preventing T Cell Leukemogenesis

The immune system recognizes and eliminates an enormous array of pathogens due to the diverse antigen receptor repertoire of T and B lymphocytes. However, the development of lymphocytes bearing receptors with unique specificities requires the generation of programmed double strand breaks (DSB) coupled with bursts of proliferation, rendering lymphocytes susceptible to mutations and oncogenic transformation. Thus, mechanisms responsible for monitoring global genomic integrity, such as those coordinated by the ATM (ataxia-telangiectasia mutated) kinase, must be activated during lymphocyte development to limit the oncogenic potential of antigen receptor locus recombination. I show that ATM deficiency compromises TCRα recombination and the post-mitotic survival of T-cell receptor αβ (TCRαβ+) CD4+CD8+ (DP) thymocytes, providing a molecular and developmental basis for the immunodeficiency characteristic of ATM loss. Moreover, I show that in early thymocyte progenitors undergoing TCRβ recombination, ATM loss leads to cell cycle defects and developmental arrest, likely facilitating the acquisition of mutations that contribute to leukemogenesis. Using ATM deficiency as a murine model of T cell precursor acute lymphoblastic leukemia (T-ALL), I demonstrate that IL-7 signaling, a critical survival and proliferation signal during early stages of normal thymocyte development, is also required for leukemic maintenance. Moreover, we show for the first time that in normal and leukemic thymocyte precursors, interleukin 7 receptor (IL-7R) expression and function are controlled by Notch signaling, a key determinant of T cell fate. Collectively, these findings provide insight into the mechanisms by which ATM promotes normal lymphocyte development and protects from neoplastic transformation, while establishing the groundwork for assessing the molecular events that lead to the initiation and stepwise progression of T cell leukemogenesis.

Keywords: ATM
T cell development
T cell leukemia
Advisor: Danska, Jayne
Guidos, Cynthia J.
Effective Neutrophil Activation During Innate Immunity: Understanding the Specific Roles of Rac1 and Rac2

Neutrophils migrate rapidly towards a site of inflammation and mediate bacterial killing through highly regulated pathways that involve the phagocytosis of bacteria and the generation of reactive oxygen species by the NADPH oxidase complex. The Rac small GTPases have prominent roles in the regulation of neutrophil signaling pathways but the research strategies used to analyze their functions in live cells have been limited, since neutrophils are terminally differentiated and difficult to manipulate genetically. In this thesis, I describe a novel high efficiency protocol for transiently transfecting neutrophils that allowed me to investigate the roles of Rac1 and Rac2 in neutrophils in a completely new way, in real time. Using this technique, I show that a bacterial protein known to inhibit chemotaxis in vitro, selectively inhibits Rac1 activation downstream of fMLP stimulation and inhibits neutrophils polarization. Further dissecting the roles of Rac isoforms, I used various approaches to show that Rac1 and Rac2 differentially regulate free-barbed end (FBE) formation downstream of the fMLP receptor. Rac1 is responsible for ~30% of FBE whereas Rac2 is the regulator of FBE formation (~70%) through the activation of cofilin and Arp2/3. Finally, these observations led to the analysis of the mechanisms underlying the Rac1 and Rac2 functions. I show that membrane charge determines Rac1 and Rac2 differential localization during phagocytosis and chemotaxis iii based on their different aminoacid residues in the polybasic domain. This mechanism depends on lipid metabolism and the accumulation of negatively charged lipids at cellular membranes. During chemotaxis, neutrophils have a polarized accumulation of negatively charged lipids at the leading edge membrane that selectively recruit Rac1. In contrast, the lipid metabolism that occurs at the phagosome membrane decreases its negativity and selectively recruits Rac2. All together, this thesis describes the study of primary neutrophil functions from a new angle and adds some valuable information to the comprehension of effective neutrophil activation based on the analysis of Rac isoforms.

Keywords: Neutrophil biology
Innate immunity
Inflammation
small GTPases
Advisor: Ellen, Richard P.
Glogauer, Michael
Search for New Physics in the Missing Transverse Energy + Dijet Channel at CDF

This thesis presents the results of a signature-based search for new physics using the exclusive dijet plus missing transverse energy data sample from 2 fb^-1 of p-pbar collisions at \sqrt{s} = 1.96 TeV collected with the Collider Detector at Fermilab (CDF). A study is made of the production of events with two high energy jets and large missing transverse energy (missing E_T, or MET) in a kinematic regime requiring the scalar sum of the E_T of the two jets (referred to here as H_T) to be greater than 125 GeV and the event MET to be above 80 GeV. A second kinematic region is also examined, with the MET cut increased to 100 GeV and the H_T cut increased to 225 GeV. The number of events observed in the data is within 0.43 standard deviations of the expected number of background events in the low kinematic region, and within 0.34 standard deviations in the high kinematic region. Based on these results, 95% C.L. lower mass limits for scalar leptoquarks are extracted: 190 GeV/c^2 for 1st generation, 190 GeV/c^2 for 2nd generation, and 178 GeV/c^2 for 3rd generation production. The results are also interpreted in terms of cross-section limits on generic minimal supersymmetric (MSSM) models.

Keywords: high energy physics
particle physics
CDF
Tevatron
Fermilab
leptoquarks
supersymmetry
Advisor: Orr, Robert S.
Regulation of Toll-like Receptor Signal Transduction Pathways

The stimulation of Toll-like receptors (TLRs) by pathogen-associated molecular patterns (PAMPs) activates macrophages and dendritic cells to response to pathogens. These activated cells induce many immune-related genes, including proinflammatory cytokines which are necessary to activate immune responses against infection. TLRs and their signaling components have been linked to several human diseases, including pyogenic infection and sepsis. Sepsis often occurs in cancer patients treated with chemotherapy. The first focus of this work is to understand how TLR signal transduction pathways regulate the induction of proinflammatory cytokines. TLR stimulation triggers a signaling pathway via MyD88 and IRAK-4 that is essential for proinflammatory cytokine induction. In this study, I found that MyD88-deficient macrophages had defective c-Rel activation, which has been linked to IL-12 p40 induction. In addition, the expression of C/EBPbeta and C/EBPdelta was limited in MyD88- or IRAK-4-deficient macrophages treated with LPS. Importantly, the absence of both C/EBPbeta and C/EBPdelta resulted in the impaired induction of proinflammatory cytokines stimulated by several TLR ligands. These results identify both c-Rel and C/EBPbeta/delta as important transcription factors in a MyD88-dependent pathway that regulate the induction of proinflammatory cytokines. The second focus of this work is to understand the function of TREM2 and how TREM2 regulates TLR-mediated immune responses. TREM2 and DAP12 deficiencies were found in human patients with Nasu-Hakola disease, but the biology of TREM2 remains unclear. To study the function of TREM2 in dendritic cells, TREM2-deficient mice were generated. I found that TREM2 down-regulated the expression of proinflammatory cytokines induced by TLRs. The TREM2 ligand was expressed on activated T cells, and TREM2 enhanced the expression of IFN-gamma in antigen-specific T cells. In a mouse model of autoimmune diabetes, TREM2-deficient mice were resisted to CD8+ T cell-mediated beta-cell destruction. Therefore, TREM2 can positively or negatively regulate TLR-mediated immune responses in selective conditions. Together, the results presented in this thesis provide further understanding of how c-Rel, C/EBPbeta/delta, and TREM2 control and modulate TLR-mediated responses. Understanding these processes may ultimately provide novel therapeutic strategies to modulate immune responses in patients suffered from infectious diseases and cancer.

Keywords: TLR
Advisor: Ohashi, Pamela S.
Talons and Fangs of the Eastern Han Warlords

Warriors are a less visible topic in the study of imperial China. They did not write history, but they made new history by destroying the old. The fall of the first enduring Chinese empire, the Han, collides with the rise of its last warriors known as the "talons and fangs". Despite some classical or deceptive myths like the Chinese ideal of bloodless victories and a culture without soldiers, the talons and fangs of the Eastern Han warlords demonstrated the full potential of military prestige in a Confucian hierarchy, the bloodcurdling reality of dynastic rivalry, as well as a romantic tradition infatuated with individual heroism.

Keywords: history
imperial china military
Advisor: Guisso, Richard
A Stochastic Inventory Model with Price Quotation

This thesis studies a single item periodic review inventory problem with stochastic demand, random price and quotation cost. It differs from the traditional inventory model in that at the beginning of each period, a decision is made whether to pay the quotation cost to get the price information. If it is decided to request a price quote then the next decision is on how many units to order; otherwise, there will be no order. An (r, S1, S2) policy with r < S2, S1 <= S2 is proposed for the problem with two prices. It prescribes that when the inventory is less than or equal to r, the price quotation is requested; if the higher price is quoted, then order up to S1, otherwise to S2. There are two cases, r < S1 or S1 <= r. In the first case, every time the price is quoted, an order is placed. It is a single reorder point two order-up-to levels policy that can be considered as an extension of the (s, S) policy. In the second case, S1 <= r, it is possible to “request a quote but not buy” if the quoted price is not favorable when the inventory is between S1 and r. Two total cost functions are derived for the cases r < S1 <= S2 and S1 <= r < S2 respectively. Then optimization algorithms are devised based on the properties of the cost functions and tested in numerical study. The algorithms successfully find the optimal policies in all of the 135 test cases. Compared to the exhaustive search, the running time of the optimization algorithm is reduced significantly. The numerical study shows that the optimal (r, S1, S2) policy can save up to 50% by ordering up to different levels for different prices, compared to the optimal (s, S) policy. It also reveals that in some cases it is optimal to search price speculatively, that is with S1 < r, to request a quote but only place an order when the lower price is realized, when the inventory level is between S1 and r.

Keywords: Inventory model
price quotation
stochastic demand
stochastic price
Advisor: Lee, Chi-Guhn