VictorJuiz/thesis huggingface dataset:
‘forms of human pow’r’: Coleridge's political poetics 1794-1802

This thesis examines how Samuel Taylor Coleridge’s choices of poetic subject, language, and form interacted with his political ideas. The poetry which Coleridge cited, to which he alluded, and to which he responded indicates his shifting political attitudes, and his place within contemporary debates.
Coleridge’s early verse responds to a Whig verse tradition, especially to Mark Akenside’s poetry. Coleridge adapts Akenside’s poetics to more radical ends. Additionally, Coleridge incorporates a sentimental poetics influenced by William Lisle Bowles into his verse in order to address the critique of the French Revolution, by Edmund Burke, that its advocates lacked connection to normal human feeling and experience. Two years later, Coleridge’s Fears in Solitude quarto can be understood as speaking to two audiences. The influence of William Cowper gave these poems the appearance of Whig political respectability and theological orthodoxy, but they also progressed in dialogue with poems by the radical lecturer John Thelwall. Coleridge directs his despairing radical contemporaries to recover liberty through religious faith.
However, ‘The Rime of the Ancyent Marinere’ responds to Wordsworth’s The Borderers to question Coleridge’s earlier political assertions. While Wordsworth’s drama is a repudiation of his enthusiasm for William Godwin, ‘The Rime’ offers a sceptical appraisal of Coleridge’s previous political statements and their underlying Unitarian philosophy.
From 1797 to 1802, Coleridge’s career as a poet for The Morning Post complemented his political prose for the same paper. His other poetry of the period, such as Christabel and ‘Kubla Khan’, comments on the problem of abstraction in political discourse. Coleridge suggests that political leadership is only effective if it is based on genuine metaphysical insight. Consequently, ‘Dejection: An Ode’ can be read as a political poem: no longer laying claim to such insight himself, Coleridge renounces the role of the political poet.

Advisor: Perry, S
The molecular and cellular basis for oncogene collaboration in acute myeloid leukaemia

Acute myeloid leukaemia (AML) is an aggressive malignancy of the bone marrow caused by the uncontrollable proliferation of immature myeloid cells that fail to terminally differentiate. Mutations in AML are acquired hierarchically, where pre-leukaemic mutations are acquired within haematopoietic stem cells (HSCs); while secondary mutations, such as signalling mutations, are acquired within downstream pre-leukaemic progenitor cells. Why certain mutations are pre-leukaemic and thus acquired within the HSCs, compared to others, and the mechanism by which pre-leukaemic and secondary mutations collaborate, are still poorly understood.
Utilising knock-in mutant mouse models we showed that HSCs expressing the pre-leukaemic fusion protein Aml1-ETO conferred a competitive advantage. However, activated K-Ras in Aml1-ETO-expressing HSCs had a marked detrimental effect, leading to cell cycle activation and loss of self-renewal associated gene expression. This provides a mechanism for the observed absence of a signalling mutation in pre-malignant HSCs.
The specific association between the biallelic CEBPA and zinc finger 1 (ZF1) GATA2 mutations is observed in AML as well as acute erythroid leukaemia (AEL). We show the mutations collaborate to generate a model of AEL with bi-lineage transformation of the myeloid and erythroid lineages. This is due to the biallelic Cebpa mutations reprogramming the neutrophil-monocyte progenitors (NMPs) to acquire ectopic erythroid potential, while the Gata2 mutation synergises with the Cebpa mutations to impair erythroid differentiation progression. The investigation of ZF1 Gata2 mutation in isolation at both heterozygous and homozygous level showed the ZF1 mutation results in loss of Gata2 function only when the mutation is homozygous. As ZF1 GATA2 mutations are heterozygous in patients, this data supports the findings that ZF1 GATA2 and CEBPA mutations must work synergistically to cause leukaemia development.

Advisor: Nerlov, C
Mead, A
Insights into transition metal catalysed asymmetric transformations

A crucial element in successfully developing efficient asymmetric catalytic reactions is finding a suitable chiral catalyst. Ligand discovery/development is not always easy to achieve. The most common practice often relies on trial and error. To move away from this, we have adopted a systematic approach that integrates traditional experimental screening approaches with statistical models (QSSR) and DFT calculations. Our aim is to increase useful information drawn from the experimental results, rather than just relying on chemical intuition alone.
We have applied this approach to two copper catalysed conjugate addition reactions and an iridium catalysed hydrogenation, all of which involved chiral phosphoramidite ligands. The QSSR models are shown to be both predictive and informative. This approach is not limited to only transition metal catalysed reaction or only with phosphoramidite-type ligands. In theory, it is applicable to any asymmetric transformation of interest involving any type of ligand.

Advisor: Fletcher, S
Paton, R
Identity and decolonisation: The policy of partnership in Southern Rhodesia 1945-62

In 1953, the Federation of Rhodesia and Nyasaland was created through an agreement between the British government, the Southern Rhodesian government, and the elected legislators of Northern Rhodesia and Nyasaland. An integral part of the Federal project was the policy and ideal of ‘partnership’ between the races, as distinct from South African apartheid and African nationalism. It was hoped by many of the participants, both white and black, that partnership would be a new approach to race relations in a continent which was in considerable ferment.
This thesis evaluates the concept and practice of partnership from 1945 to 1962. It argues that partnership was an attempt by the Rhodesian elite to effect a self-decolonisation: ceding enough power to co-opt the African middle class without radical alteration of the Rhodesian system which thus far has provided a comfortable lifestyle for the whites. Partnership arose from the Rhodesian mental ‘reality’ which held that there was a ‘ladder of civilisation’ which everyone, regardless of race, could climb, allowing the system a certain flexibility. As such it was markedly different from South African apartheid which discriminated on the basis of race alone. This thesis analyses the concept and practice of partnership separate from any moral judgements on failures to deliver on its promises, treating it as an exercise in realpolitik by a white elite trying to accommodate change.

Advisor: Ranger, T
Lowry, D
The language of covenant

The centrality of covenant in the Hebrew scriptures has made it a theme of enduring significance. Accordingly, the language of covenant has acquired a corresponding importance. Whereas study of the language of covenant has not been neglected by scholars. the combination of impetus from ”Biblical Theology,” together with the tenets of traditional philology, has resulted in word-studies, which regard words as convenient labels for concepts. Some of the dangers of this approach have been exposed by Dr. James Barr, and, in the realm of New Testament Greek research, Dr. Nigel Turner has sought to explore the value of syntax and style. The present dissertation constitutes a determined attempt to discover the values of a similar approach to Biblical Hebrew semantics, in the restricted field of covenant language. If this approach has an appearance of being somewhat pedestrian, then that is due, in large part, to the absence of the kind of literature that facilitates the task of lexicography; the spadework of structural semantics is yet to be done, and the ground is fallow. The aim, therefore, is an articulation of the semantic structures of language associated with ברית. If any justification for this be required, then this writer's apology will be the same as Dr. Turner's: “my apology must be that the mechanics of speech provide a delicate and flexible means of communication which is worth scientific study.”
Continued in theses ...

Keywords: covenant
semantics
biblical
semantic
Genesis
berit
Hebrew
Bible
Algebraic quantum structures for reference frame-independent quantum teleportation and pseudo-telepathy

Part I: We present two new schemes for teleportation of a quantum state between parties whose local reference frames are misaligned by the action of a compact Lie group G. These schemes require no prior alignment of reference frames and are unaffected by arbitrary changes in reference frame alignment during execution, suiting them to situations of rapid reference frame drift. Our tight scheme yields improved purity compared to standard teleportation, in some cases substantially ---including the case of qubit teleportation under arbitrary SU(2) reference frame uncertainty--- while communicating no information about either party's reference frame alignment at any time. Our perfect scheme performs perfect teleportation, but does communicate some reference frame information. The mathematical foundation of these schemes is a unitary error basis permuted up to a phase by the conjugation action of a finite subgroup of G; we completely classify such unitary error bases for qubits, exhibit constructions in higher dimension, and provide a method for proving nonexistence in some cases.
Part II: Quantum pseudo-telepathy is a phenomenon whereby two non-communicating parties can use the non-signalling correlations from shared quantum entanglement to perform a task that would ordinarily be impossible without communication. Here we consider the graph isomorphism game: an instance of the game is defined by a pair of graphs, and a perfect deterministic classical strategy precisely corresponds to an isomorphism of those graphs. We call a pair of graphs for which a perfect strategy using shared entanglement (a quantum strategy) exists pseudo-telepathic, and call a quantum strategy a quantum isomorphism between the graphs. Using a deep connection between noncommutative mathematics and nonlocal games, we classify all graphs quantum isomorphic to a given graph in terms of the quantum automorphism group of the graph. This implies a construction of quantum isomorphisms from central type subgroups of the ordinary automorphism group; we give an explicit description of the resulting quantum strategy and the new graph. We consider generation of new examples of quantum contextuality from central type groups. For abelian central type groups we show that this reduces to construction of quantum solutions of a binary linear constraint system from the abelianisation of its homogeneous solution group.

Keywords: quantum algebra
pseudo-telepathy
linear constraint system games
projective representation theory
noncommutative mathematics
groups of central type
nonlocal games
quantum graph isomorphisms
Teleportation
noncommutative graphs
Advisor: Vicary, J
The language of wealth in Old English literature: from the conversion to Alfred

This thesis analyses the language used to refer to wealth, and attitudes towards wealth, in the Old English literature of the earlier part of the Anglo-Saxon period. I firstly consider poetry such as Beowulf, the Junius 11 Old Testament poems and the works of Cynewulf, in order to develop an understanding of the treatment of wealth in vernacular literature before Alfred’s reign, but the primary concern of the thesis is with the canonical texts of the Alfredian corpus: the Pastoral Care, the Boethius, the Soliloquies and the first fifty Prose Psalms. While my focus is on these texts, given their stylistic and linguistic similarity, I also refer to other works associated with the Alfredian programme, including the Orosius, the Dialogues and the Bede. Although this thesis is not directly concerned with the issue of Alfred’s authorship, the conclusions nonetheless support the case for a unified, Alfredian context for the canon, based on ideological similarities between all four texts and the Alfred Jewel. This thesis combines elements of comparative reading and word study, distinguishing it from previous studies of the Alfredian texts. My methodology makes use of digital corpora, allowing me to situate the linguistic trends of the Alfredian texts within the wider Old English corpus.
The topic of wealth highlights a significant difficulty facing the Alfredian author(s): the confrontation between the native, vernacular tradition, in which the appreciation of material wealth plays a central role, and the Latin, Mediterranean source texts, which treat wealth as false and fleeting. The accommodation between native, Germanic culture and imported Christianity had obviously been ongoing since the conversion. However, this particular moment is worth attention as the Alfredian corpus represents the crest of the growing wave of literary, vernacular prose that had been building momentum in the form of the more pedestrian Mercian translations, such as the Dialogues and the Bede. Moreover, wealth is particularly significant in the Alfredian context, given the striking pairing with wisdom in the prose preface to the Pastoral Care, a pairing manifested in the Alfred Jewel, which in all likelihood accompanied the translation.
This thesis demonstrates that the texts of the Alfredian corpus share an ideology which recognises the usefulness of wealth while nonetheless warning against the dangers it poses as a distraction from the pursuit of wisdom. I suggest that this balanced perspective implies a secular or mixed context for the translations. My analysis of wealth, with particular focus on language, shows that the corpus encourages its readers and listeners to redirect their attention from material riches, useful though they may be, to the riches of wisdom.

Keywords: Wealth
Alfred the Great
Advisor: Leneghan, F
Investigating the role of lysine demethylase UTX-1 in lifespan regulation of C. elegans

That ageing can be epigenetically regulated has garnered considerable interest due to the implication that ageing is incredibly plastic and therefore, potentially reversible. Overexpression and downregulation of
utx-1
(H3K27me2/3-specific lysine demethylase UTX-1) was found to promote lifespan extension in C. elegans. Because utx-1 is ubiquitously expressed, it was hypothesised that lifespan is differentially affected, depending on the tissue where utx-1 expression is manipulated. Hypodermis-, intestineand neuron-specific knockdown of utx-1 (but not muscle) was found to promote lifespan extension in worms, whereas, overexpression of utx-1 only in intestine and neurons (but not muscle and hypodermis) promoted longevity. The catalytic activity of UTX-1 was found to be necessary for lifespan extension due to utx-1 overexpression and RNA-Seq studies showed that utx-1 overexpression is associated with upregulation of defense and immune response genes – a possible protective mechanism that indirectly promotes lifespan extension in worms. Finally, hsp-1 (heat-shock protein hsp-70) was discovered to be absolutely required for lifespan extension due to utx-1 overexpression, suggesting that the heat-shock response is crucial for lifespan regulation mediated by utx-1 overexpression. Overall, the work in this thesis, which also includes analysis of cbp-1 (H3K27 acetyl transferase), suggests that lifespan regulation due to H3K27 modification is incredibly complex and that longevity is mediated differentially as a consequence of different doses of modifier, and in specific tissues, likely due to transcriptional changes mediated by the demethylase function of UTX-1.

Keywords: C. elegans
utx-1
chromatin
ageing
Advisor: Woollard, A
Government revenue, 1793-1815

The thesis began as a study and evaluation of the methods employed by the British Government to finance the wars against France from 1793-1815. Public finances of the late 18th and early 19th centuries is such a neglected field by economic historians that secondary sources on the operation of the financial system scarcely exist. Yet in order to understand the finance of war it is essential to comprehend the whole financial system. Thus a large part of the thesis will be concerned simply to analyse public finances as they operated at the outbreak of war. With this context in place the thesis will proceed to outline the methods employed and the problems encountered by the Government in raising revenue to pay for the war. Finally, the thesis endeavours to appraise and criticise the techniques utilised mainly within the context of the constraints and nature of the financial system, but to some extend for their effects on the population and the course of economic growth over the period.
It is written primarily from the discipline of economic history but inevitably and frequently passes into administrative and economic history. The questions raised could not be answered within the confines of a single discipline.
My research cannot be offered as answers to a single question or set of hypotheses. The questions which underlie it are already stated. In so far as I have a single thesis or conclusion it is that, given the nature and constraints of the financial system, the Ministers, civil servants and their advisers responsible for providing the indispensable monetary means to obtain resources to prosecute the war, on the whole performed their task with commendable efficiency.

Keywords: government
revenue
Britain
France
finance
wars
policy
fiscal
war
Advisor: Habakkuk, H
Atomic mixtures in radiofrequency dressed potentials

We have developed experimental techniques to confine two species of ultracold atoms in trapping potentials that are independently controlled by applied radiofrequency (rf) fields. Elementary species-selective manipulations are demonstrated for the isotopes 85Rb and 87Rb, such as changing the relative positions of the species. More detailed manipulations are possible, such as creating a double-well potential for one species that is overlapped with a single harmonic well of the other.
We observed that both isotopes have long lifetimes in the rf-dressed potentials when separate; this is well known for 87Rb which has very favourable collision properties, but the stability of 85Rb in rf-dressed potentials had not previously been demonstrated. A large rate of inelastic inter-species collisions was observed when the clouds were brought together, and our results identify this as being due to two-body collisions between 85Rb and 87Rb. We explain the origin of these losses using a qualitative model. Our experimental data is compared to computations of the inelastic loss rate coefficients that have been carried out using coupled-channel calculations by theoretical chemists at Durham University.
We have created double-well potentials for ultracold atoms by dressing with three rfs, as reported in our published work. Since this first demonstration we have eliminated sources of noise from the experimental apparatus using a systematic method, enabling a quantum degenerate gas of 87Rb to be loaded into a double-well potential with 6.7 micron separation between the wells. This is an order of magnitude improvement over our previously published work, and this separation is confirmed by matter-wave interference observed between atoms released from the two wells. In the near future, this apparatus will be able to split a quantum degenerate, two-dimensional gas, as has been performed for one-dimensional gases elsewhere. Moreover, many technical improvements have been implemented, allowing large amounts of data to be measured under highly reproducible conditions.

Keywords: Adiabatic potentials
Matter-wave interference
Bose-Einstein condensate
Radiofrequency-dressed potentials
Ultracold atoms
Advisor: Foot, C
Urban musical modernism in ‘broken Britain’

Since the widely acknowledged death of postmodernism, debates about the ongoing importance of musical modernism have raged. But scholars have found it difficult to square this efflorescence of contemporary modernist thought with the ongoing sense that modernism should be more plural, encompassing music from the low side of the great divide. Focusing on Britain, this study looks at the cross-currents between contemporary classical and ‘urban’ popular musics that seek to make a statement about the cultural diversity of a British national identity, while at the same time securing prestige through institutional support. The thesis balances issues of intention against matters of reception, considered through texts aimed at a broad audience – newspaper and magazine sources, radio and television broadcasts, publicly available musical scores, and websites – which it reads critically alongside primarily historical musicological literature, with the addition of some work on urban geography, and sociological work on artistic consumption. Modernist and urban popular music prove to have found common ground in a strand of vernacular modernism that has often been concerned with popular or folk influences, and anxieties surrounding the machine-age; composers of contemporary modernist music appropriate rap, dance, and electronic musical styles in an attempt to resist cultural superiority, with a view to achieving the cultural superiority associated with modes of resistance. The thesis charts a broad trajectory over six chapters, from the interaction between urban popular and avant-garde styles at the BBC Proms in Chapter One, to the material effects of bringing an urban modernism to new audiences and urban spaces in Chapter Six. By painting a detailed picture of the complex and often contradictory ways in which these urban popular styles support or undermine the avant-garde, the thesis concludes by supporting ongoing critical work into the nature of innovation through resistance that has been central to definitions of modernism.

Advisor: Franklin, P