VictorJuiz/thesis huggingface dataset:
Editing the Sandor Ferenczi-Georg Groddeck correspondence, 1921-1933, a work in progress

Of the early psychoanalysts, Sandor Ferenczi (1873-1933) was considered the most brilliant therapist--acknowledged by Freud to be a "master of analysis." Georg Groddeck (1866-1934), a German physician, was the source for Freud's concept of the "Id" and is sometimes referred to as the "father of psychosomatic medicine." The correspondence, which is primarily Ferenczi's letters to Groddeck, provides important new insights into Ferenczi's professional and personal life, including: (1) Ferenczi's radical clinical and theoretical experiments and his reconsideration of the importance of early trauma. (2) Ferenczi's challenge to the traditional limits of the doctor-patient and analyst-analysand relationship. (3) the complex emotional triangle involving his wife and step-daughter. (4) the impact of his own early traumas. (5) Ferenczi as a chronic patient, plagued by physical ailments. Ferenczi's determination to understand his personal history and heal himself led him to critique fundamental aspects of classical psychoanalysis. These letters illuminate the personal roots of his professional drive. A historical perspective on the evolution of Ferenczi's ideas is critical since it reveals the origins of basic structures of present-day psychoanalysis including: object relations--intersubjectivity and mutuality, analyst subjectivity--the use of countertransference, and the role of childhood trauma in later mental, emotional and physical life. Different than his letters to Freud, whom he saw as a father figure, Ferenczi pursued a more open friendship with Groddeck, as though he were a favourite older brother. They explored ideas including: self-analysis, mutual analysis, the body-mind relationship and wrestled with the question of whether psychoanalysis could be a science. The letters resonate with critical theoretical and clinical issues today. Chapter I is an Introduction. Chapter II consists of the Ferenczi-Groddeck letters, with extensive annotations, in three sections: 1921-1922, 1923-1926, and 1927-1933. Chapter III contains an exchange of letters in 1933-1934, after Ferenczi's death, between Ferenczi's wife, Gizella, and Groddeck. Chapter IV is a Commentary evaluating the significance of the correspondence for the history of psychoanalysis. It includes a discussion of the key letter of the correspondence, and addresses themes of Ferenczi's personal and professional life, including: recognition of childhood traumas, drive for relationship, regression, identification with the child, body, health and psycho-somatics, and disclosure of negative feelings. The Commentary also explores a number of ideas between Groddeck and Ferenczi, including: Groddeck's influence and importance, the child and the significance of the mother, how Groddeck inspired Ferenczi, writer's block, 'Thalassa ', and the courage to create, and the body between Ferenczi and Groddeck. Appendices include a chronology of the letters, and a note on method and sources.
Association of a nonsense mutation at the codon for Glu 54 in the GM2A gene with AB variant G¦M¦2 gangliosidosis, characterizing the intron/exon junctions of the gene

The AB variant form of GM2 gangliosidosis is an inherited lysosomal storage disease caused by mutations in the 'GM2A ' gene. In this study, the intron/exon junction of 'GM2A' gene was characterized, and a PCR procedure was developed to quickly analyze the 'GM2A' gene for mutations. Meanwhile, a new AB variant patient was detected and characterized. The patient was found to be deficient in both GM2 activator protein and mRNA. RT-PCR and sequencing detected some normal size cDNA (containing a single nonsense mutation in exon 2 (Glu54STOP)) along with a lower-level of a smaller cDNA species (an inframe deletion of exon 2 ([Delta]E2)). Further experiments excluded the possibility that [Delta]E2 species was a product of abnormal splicing from a second mutant allele. Finally, through restriction digestion and nested amplification of RT-PCR product, the normal sample was also found to contain [Delta]E2 species mRNA. Therefore, a Glu54STOP nonsense mutation and a naturally occurring transcript of [Delta]E2 were identified.
Contesting conventional order to promote equality, a life history study

This life history research explores the stories of women educators who contest conventional order to promote equality. Seven research participants, representing a variety of professions, were selected for the inquiry because of their pioneering public work to decrease inequalities consequent to ageism, classism, racism, sexism and stigmatization of people with chronic illness. The research focus was to explore the women's unique, historically situated experiences of contesting conventional order to promote equality and to illuminate social processes and conditions related to the phenomenon. The theoretical basis of this life history research is located within the constructivist paradigm; symbolic interactionism and critical feminist theory provided grounding for the study of social life and human conduct. I shared formative life stories to situate my perspective as a researcher. Initially, the participants engaged in three loosely structured interviews. The research participants' stories were condensed and shaped into profiles using their own words and according to the research focus. I introduce the profiles according to theoretical and contextual applications that arose from the participants' voices and actions. The disjunctive moment--that space of deliberation, of simultaneously seeing the deficiencies of the status quo and of envisioning new possibilities for action-is described differently by every woman. I analyzed the profiles and supporting documentation to identify a theme for each woman that connected different aspects of her life history. The themes represent each woman's particular impetus for seeing injustice and constructing acts to increase equality for segments of the population. The interconnections between themes are described from a social activism perspective. Finally, the "inclusive eye" is an image used to synthesize the research findings. When research participants use an "inclusive eye" to see, their stories erode boundaries to advance the well-being of oppressed and non-oppressed people alike.
The essential, interactive relationship between a creative thinker and an audience

The relationship between a creative thinker and other people raises many questions. Thought expressed in a language, perhaps mathematics, dance, sculpture, English, has a product, performers and an audience. What is a creative thinker? Do thoughts require expression at all? What is language? Are the limits of language too confining for some thoughts or too traditional to express a radically new idea? Is a listener likely to understand the thought itself, with some of the context, and is this understanding possible or unlikely considering the differences between people, especially over time and place? Does the recipient of the thought require training to understand the subtleties of the expression? Does the performer of the product offer an accurate interpretation of the thought, and will the audience be able to make the leap in imagination required to understand it? If translation is necessary what are the limits of accuracy, depending on the faithfulness of the translator? This dissertation's focus is the relationship between the thinker and the language chosen to express a thought; the relationship between interpretation by the recipients (performer, critic, or audience) and the original expression; the relationship between people, across history, culture and time who receive the expression and try to understand it, and the original creative thinker. This relationship is both interactive and essential; interactive because the creative thinker is attempting to express a thought to someone else and has an audience in mind, or the audience may have been unimaginable to the thinker. The choice of the language has limitations and sometimes the thinker pushes at the limits of this language to effectively articulate the thought, especially if it is new or different. The recipients who interpret the expression also transform the thought with their experiences and biases. How far can the thought be transformed before it is changed rather than enriched by this interaction? And where does truth lie in this relationship? The relationship is essential because without each of its participants it would not exist. Each component is interdependent, shaped by each, and has a place in history because of each. These questions will be explored.
Psychotherapeutic experiential interventions for activists, examining the Despair and Empowerment paradigm

Burn out literature substantiates activists' stress. Political critiques of psychology examine tensions between personal and political needs. From four semi-structured qualitative interviews with facilitators of the "Despair and Empowerment" paradigm, I examine how the personal and political can be integrated into experiential workshops. These facilitators generate discourses about psychotherapeutic interventions sustaining activism. Central questions were: (1) how workshops integrate the personal and political; (2) how facilitators see emotional exploration affecting activism; (3) how some activists experience stress; (4) how notions of activism and political praxis are constituted by facilitators, the "Despair and Empowerment" paradigm and political activists. My research expectation is not to provide definitive representations of the intervention, facilitators, or activists. Rather, layers of discussion about pedagogy, healing and practices of social change are offered to further develop praxis in myself, the research and workshop participants, and others committed to personal and social healing and transformation.
Nitrosohemoglobin synthesis

Nitrosohemoglobin synthesis parameters were optimized to produce a pigment which was readily soluble in a pickling liquid. Optimum reaction pH was approximately 6. Optimum homogenizing speed was 9,000 rpm for 10 minutes. Optimum contact time of hemoglobin with nitric oxide was 4 minutes, at 135 mL/min. The average iron content of the dried nitrosohemoglobin was approximately 3000 ppm, making the payload of spray and freeze dried pigments 3.18% and 3.26% respectively. Solubility experiments of dried pigments in 0.04M sodium carbonate revealed optimum solubility between pH values of 9 and 11. Mixing by means of a magnetic stirring was optimim. Low and nitrite-free hams were made on a semi-industrial scale level using spray and freeze dried nitrosohemoglobin, standard DNFH pigment and a full nitrite standard. Low nitrite freeze dried nitrosohemoglobin hams were visually and quantitatively closest to full nitrite standard. Both dried nitrosohemoglobin pigments had no pigment accumulation at muscle membranes.
Gulliver's travels and constructs of the primitive in Swift's time

The purpose of this thesis is to interrogate constructs of The Primitive in seventeenth- and early eighteenth-century Britain and to consider how these constructs inform Jonathan Swift's works, particularly 'Gulliver's Travels' (1726). Primitivist constructs pervade English ideas in the period as voyagers returned with stories of strange peoples, which upset the stability of anglocentrism. Changes in scientific and philosophical methodology interacted with a new interest in travel writing, and thinkers such as the scientist Edward Tyson and the 3rd Earl of Shaftesbury effectively evoke this symbiosis. In general literature The Primitive functioned temporally as a pre-historiographic or infantile past of the writer's present or spatially as a contemporary but geographically distant other. Writers sometimes idealized The Primitive, as in Dryden's Mexican tragedies, 'The Indian Queen ' and 'The Indian Emperour'. In travel writing-both experiential (e.g., William Dampier, Thomas Herbert, Lady Montagu) and imaginary (e.g., Tom Brown, Daniel Defoe, William R. Chetwood)--constructs of The Primitive consist of three types: The Exotic (such as the refined but heathen Turks), The Barbarous (such as the admirable but unlettered Native Americans), and The Savage (such as the fascinating but seemingly irredeemable Hottentots). Primitivist types also occur in Swift's works, as when in 'A Modest Proposal' Swift champions the Irish but also constructs them as a negatively different other. 'Gulliver's Travels' consists of dual primitivist narratives: one with Gulliver as a conventional traveler-observer and his hosts as constructs of The Primitive and the simultaneous other with Gulliver adopting his hosts' perspectives and thereby appearing as The Primitive himself. As a primitive type, he moves from land to land and cycles through the three primitivist constructs--The Exotic in Lilliput, The Barbarous in Brobdingnag, and The Savage in Laputa--while reverting to his Civilized status at home. In Houyhnhnmland Gulliver becomes trapped between his longing to become more Houyhnhnn and his knowledge that he is more Yahoo, and he finally eschews his liminal humanity to degenerate into bestiality. In the ' Travels' Swift critiques the colonial imperative even as he acknowledges its appeal, and by creating a dual man living in a dual narrative, Swift reifies the subjective tension of self and other.
Quantitative analysis of changes in limbic structures in probable Alzheimer's disease using coregistered SPECT and magnetic resonance imaging

'Background'. This study used MRI and coregistered SPECT to examine the changes that occur in the limbic system in Alzheimer's disease (AD). 'Methods'. A group of 40 AD patients was compared to a group of 40 age, sex, and education matched normal controls. Limbic structures (i.e., hippocampus, amygdala, anterior thalamus, hypothalamus, mamillary bodies, basal forebrain, septal area, fornix, and cingulate, orbitofrontal, and parahippocampal cortices) as well as non-limbic structures (i.e., posterior thalamus, caudate nucleus) were traced on a T1-weighted MR image using multiple slices and planes according to a set of predetermined guidelines. These traces were used to determine structural volume in order to assess the changes that occur in AD vs. normal aging. SPECT images from the same individuals were coregistered with the T1-weighed MR scans using a pixel by pixel algorithm from the AIR 3.0 software package (Woods et al., 1998). Once aligned, the tracings made on the MR image were transferred to the coregistered SPECT and used as regions of interest to obtain anatomically accurate, semi-quantitative limbic measures of perfusion relative to the cerebellum. 'Results'. Overall, the structures of the limbic system showed both volumetric and relative perfusion reductions in AD patients compared to normal controls. Some of these measures--namely, the volume of the septal area and medial amygdala-anterior parahippocampal cortex and the perfusion ratio of the posterior cingulate cortex--when used in combination, had high predictive accuracy (up to 100%). Sex differences were noted in the pattern of limbic atrophy and hypoperfusion associated with AD with men showing more widespread atrophy and hypoperfusion than women. Differences were also detected between AD patients with mild and more severe cognitive deficits. This suggests that volumetric and perfusion reductions become progressively larger over the course of the disease, although this could not be confirmed in a small longitudinal sample. 'Conclusions '. The limbic system is an integral part of AD pathology. Examining the volume and perfusion of limbic structures using MRI and SPECT may be useful in diagnosing and monitoring the progression of AD.
The time course of naloxone-induced recurrence of mustard oil-evoked jaw muscle electromyographic activity

It has been documented that systemic administration of the opiate antagonist naloxone induces a recurrence of increased EMG activity in the jaw muscles initially evoked by application of mustard oil (MO), a small-fibre excitant and inflammatory irritant, to the temporomandibular joint (TMJ) region of rats. The aim of this thesis study was to further characterize this naloxone-induced recurrence of EMG activity by determining the time course of naloxone action. In 60 anaesthetised rats, EMG activity was recorded bilaterally from digastric and masseter muscles. Naloxone (1.2 mg/kg) was administered at different time periods relative to the MO injection. Both the magnitude and incidence of rekindling were greatest when naloxone was administered 30 minutes after MO. There was no effect of pre-load of naloxone on the magnitude of the MO-evoked response. These data suggest a time course of naloxone-induced rekindling, implying a time course of opioid modulation in response to tissue injury.
A PET study of the noradrenergic system, gender differences and depression effects

Purpose. This study is a PET examination of central noradrenergic function in depression and in healthy volunteers using the clonidine challenge test as a neuroendocrine probe. Method. All subjects were right-handed, not taking any medications, and non-smokers. The depressed female subjects were diagnosed by the Structured Clinical Interview for Diagnosis for DSM-IV criteria for major depression and by a clinical consultation. The severity of their depression was assessed with the 17-item Hamilton Depression Rating Scale (HRSD) with a minimum score of 18. Matched healthy female volunteers by age $\pm$2 years and phase in menstrual cycle were recruited, as well as healthy male volunteers. Subjects received a clonidine infusion of 1.4 $\mu$g/kg intravenously. For the female subjects, regional cerebral blood flow (rCBF) was measured with two scans at baseline and two scans following the clonidine infusion with H$\sb2\sp{15}$O using PET. For the male subjects, rCBF was measured with two scans at baseline and three scans following the clonidine infusion. During the scans, each subject's activity was standardized with a continuous performance task. (Abstract shortened by UMI.)
Developing tissue-specific inducible expression systems

Inducible expression systems allow the external regulation of gene expression and enable gene function analysis to be performed in a dose-dependent manner. We developed an epithelium-specific tetracycline inducible system using the regulatory elements of the human cytokeratin 19 gene. High levels of expression were achieved in a dose-dependent manner in cultured lung epithelial cells, ' in vitro'. Only very low levels of expression were observed in cultured fibroblast cells. In transgenic mice we demonstrated the ability of the system to regulate inducible expression of a reporter gene in the epithelia of the upper airways and the submucosal glands. RNA analysis revealed a cryptic splicing reaction in the RNA expression of the transactivator protein. Modifications to the expression construct were made and mutants were screened for increased expression. One construct, with a modified 3' untranslated region, was capable of inducing 60% greater expression than our first generation construct. This modified construct was used to test a complimentary tetracycline regulatable inducible system. Using this system, it will be possible to target the expression of a gene of interest to the lung epithelia and controlled temporally, without pleitropic effects, by the administration of doxycycline.
New applications and an implementation of higher-order queries with fixed output schemas

With current database technology trends, there are increasing needs to handle schema changes, to restructure data, and to query schemas in new applications, such as e-commerce, schema browsing, and data warehousing. Traditional query languages offer little help, because they do not allow queries to quantify over schema components, such as relation names and attribute names. Higher-order query languages, originally proposed to overcome limitations of traditional query languages in manipulating multiple databases, have been found to also play important roles in handling the above needs of new applications. In this thesis, we consider the requirements of new applications, review higher-order query languages in the literature, and employ SchemaSQL, a higher-order query language, as a vehicle to show how these requirements can be met. We also adopt SchemaSQL as an example to give a full investigation of implementation strategies for higher-order queries with fixed output schemas. This includes identification of issues, implementation architecture, relaxation of constraint checking proposed in early work, presentation of a simple and efficient non-intrusive algorithm for processing higher-order queries with fixed output schemas in a single database, and implementation of the algorithm for SchemaSQL on top of DB2. There are three main contributions in this thesis. The first is to identify the needs of new applications and show that higher-order query languages can meet these needs. The second is to identify the major issues in processing higher-order queries with fixed output schemas. The third is to present a simple and efficient algorithm with relaxed constraint checking for processing higher-order queries with fixed output schemas and to implement it for SchemaSQL in a non-intrusive way on top of DB2.
Dante and Ovid, a comparative study of narrative techniques

The dissertation focuses on the influence of Ovid ('Metamorphoses ') on Dante and is divided into two parts. The first part is concerned with the Ovidian influence on the microtextual level, that is, with the way in which Dante implements Ovidian themes in specific passages and for particular, local purposes. The second develops a wider, narratological approach, centering on the way in which Dante's story-telling style, in the broadest way, is derived from Ovid and developed in imitation of him. The thesis aims at giving an assessment of what an exhaustive account of the influence of Ovid's ' Metamorphoses' on Dante would entail, something which has never been done before. In the first chapter there is presented a complete survey of the most recent scholarship on the microtextual exploitation of Ovid's myths and legends on Dante's part. Some new criteria to produce a complete taxonomy encompassing all the passages of the 'Comedy' derived from Ovid's ' Metamorphoses' are also discussed. The second chapter, introducing the second part of the thesis, deals with semiotic concepts focusing on the general problem of literary repetition and self-exegesis in an epic poem. This, indeed, is the feature of Dante's art which owes the most to Ovid's narrative technique. The third chapter shows how Ovid himself used the device of repetition and variation on given themes, derived from his juridical training, for the purpose of granting thematic unity and consistency of tone to his unprecedented literary undertaking. The fourth chapter highlights how many passages of the 'Comedy ' are likewise connected to each other delineating sequentially significant patterns devoted to the goal of self-exegesis. This work makes use of the Dartmouth Dante Project Database, developed by Robert Hollander, which contains more than 40 commentaries on the ' Divine Comedy', from Dante's own son Pietro to 1982. An appendix containing all the passages of the 'Comedy' that all the above mentioned commentators have considered as derived from Ovid's main work has been provide after the Conclusions and before the Bibliography. All the entries have been sorted out and arranged systematically according to the succession of the canticles and the chronological order of the commentators.