VictorJuiz/thesis huggingface dataset:
Income inequality and consumer markets

This thesis consists of three chapters that analyze theoretically the role of income inequality in consumer markets. Each chapter introduces distributional considerations into an economic model where previously inequality did not play a major role.
Chapter one uses a consumer search model to show under what conditions the distribution of income within a community is related to the type of firms that exist within that community, impacting the level of prices. We show that if time and money costs of search are high enough, only the middle class have incentive to search and therefore are the most aggressive shoppers. Using a supply side model, we argue that firms located in more informed communities are more likely to enter the market as large low-priced retailers. Connecting these two results, the model shows under what conditions the size of the middle class can have a negative relationship with the level of prices.
Chapter two demonstrates how firm pricing strategy and determinants of household location can interact to determine city structure. In this city, consumers and firms live on a continuous line interval. The model consists of two types of firms; many high-cost perfectly competitive firms located in the Central Business District, and one large low-cost "Superstore", choosing its price strategically. We show how the shopping habits of the consumer population, as determined by the relative price of the Superstore and the Corner Stores, can contribute to the various income segregation outcomes described in previous literature. In addition we consider the impact of city population structure on the pricing decision of a monopolist facing a competitive fringe.
Chapter three uses a simple model of banking services to consider how deposit-taking banks price for their services and choose the type of deposit customers that they target. This chapter goes beyond previous theoretical work on consumer banking, identifying the role of household income in the access to deposit services. We show that a higher rate of return on investments available to banks lowers financial exclusion, increasing the profitability of low-income consumers for deposit-taking institutions. This suggests that the possibility of financial exclusion increases in periods of recession. The chapter demonstrates how an increase in income dispersion can lead to a greater proportion of consumers excluded from mainstream banking.

Keywords: access to banking
segregation
search
income inequality
Advisor: Atkinson, T
T cell responses in Kenyan infants: impact on  HIV-1 evolution during infection and an assessment of vaccine-induced memory responses in  HIV-exposed uninfected infants

The past 10 years has seen mother to child transmission (MTCT) of HIV-1 shift from being one of the predominant forces in the global epidemic to a phenomenon that is largely preventable and envisioned as being on the path to elimination. This thesis is based on two cohorts of Kenyan infants recruited before and after the development of effective antiretroviral interventions to prevent MTCT. Two main lines of enquiry are pursued with the aim to contribute to improved health outcomes of infants affected by HIV-1. The first seeks to further our understanding of the capacity of the infant cytotoxic T lymphocyte (CTL) response to influence viral evolutionary dynamics in early infection. Chapter 3 presents a modern phylogenetic analysis of longitudinal viral sequences derived from infants following in utero or peripartum infection. The results indicate that despite high levels of viral replication, infant CTL selection pressure plays a significant role in shaping early viral evolution. The second stems from an accumulating body of evidence that suggests that infants born to HIV-1 infected mothers who themselves are free from infection, termed HIV-1 exposed uninfected (HEU) infants, nevertheless face significantly higher rates of infectious disease- associated morbidity and mortality than HIV-1 unexposed infants. This study therefore sought to characterise the immunological status of HEU infants with particular emphasis on the phenotypic and functional properties of the T cell compartment. Chapter 4 presents the immunological characterisation of a cohort of healthy Kenyan infants recruited as a control population at two time points in early life. Chapter 5 present a cross-sectional comparison of HEU and control infant cohorts. The results suggest a level of altered immunological reactivity with respect to the T helper type 1 (Th1) response to polyclonal stimulation. In addition a compromised memory Th1 response was observed following polyclonal stimulation and following stimulation with Bacillus Calmette-Guerin and tetanus toxoid vaccine antigens.

Keywords: vaccine
infants
HIV
evolution
HIV-exposed uninfected
T cell
virus
Advisor: Rowland-Jones, S
Urban, B
Intergenic long noncoding RNAs provide a novel layer of post-transcriptional regulation in development and disease

Recent genome-wide sequencing projects revealed the pervasive transcription of intergenic long noncoding RNAs (lincRNAs) in eukaryotic genomes (reviewed in Ponting et al. 2009). For the vast majority of lincRNAs, their mechanisms of function remain largely unrecognized. However, the genome-wide signatures of functionality associated with many lincRNAs, including apparent evolutionary sequence conservation, spatial and temporal-restricted expression patterns, strong associations with epigenetic marks, and reported molecular and cellular functions, reinforce their biological relevance. My work investigates lincRNAs that post-transcriptionally regulate gene abundance by competing for the binding of common microRNAs (miRNAs) with protein-coding transcripts, termed competitive endogenous RNAs (ceRNAs) acting lincRNAs (lnceRNAs). First, I examine the biological relevance of this post-transcriptional regulation of gene abundance by ceRNAs. Next, I estimate the genome-wide prevalence of lnceRNAs in mouse embryonic stem cells (mESCs) and characterize their properties. Finally, using two specific examples of lnceRNAs, I show the contributions of lnceRNAs to human monogenic and complex trait diseases. Collectively, these results illustrate that lnceRNAs provide a novel layer of post-transcriptional regulation via a miRNA-mediated mechanism that contributes to organismal and cellular biology.

Keywords: noncoding RNA
Spinocerebellar ataxia type 7
long noncoding RNA
microRNA
competitive endogenous RNA
mouse embryonic stem cells
autism spectrum disorders
Advisor: Ponting, C
Marques, A
Total asymmetric syntheses of iminosugars

This thesis is concerned with the development of ring-closing iodoamination and ringexpansion methodology and its subsequent application to the asymmetric syntheses of pyrrolidine and piperidine iminosugars.
Chapter 1 highlights the remarkable biological properties displayed by iminosugars and introduces methods for the formation of the pyrrolidine and piperidine sub-classes.
Chapter 2 describes investigations into the ring-closing iodoamination of bishomoallylic amines which occurs with concomitant N-debenzylation to give an iodomethyl pyrrolidine scaffold. Conversion to the corresponding aziridinium species followed by its regioselective intermolecular ring-opening by H2O enabled the synthesis of (+)-2,5-dideoxy-2,5-imino-Dglucitol (DGDP). A protocol for the preparation of its 1-deoxy-1-amino analogue (+)-ADGDP was also developed.
Chapter 3 details studies into the ring-expansion of iodomethyl pyrrolidine scaffolds via the trapping of CO2 (from NaHCO3) to produce cyclic carbonates as single diastereoisomers. Subsequent deprotection of these piperidines allowed the syntheses of (−)-1-deoxymannojirimycin (DMJ) and (+)-1-deoxyallonojirimycin (DANJ) to be completed.
Chapter 4 delineates investigations into the trapping of alternative “X=C=Y” electrophiles, via the ring-expansion methodology developed in Chapter 3, initially utilising a model system. These studies culminated in the development of the trapping of p-TsNCO and the application of this methodology in the total asymmetric syntheses of (−)-ADMJ and (+)-ADANJ, the 2-deoxy-2-amino analogues of (−)-DMJ and (+)-DANJ, respectively.
Chapter 5 contains full experimental procedures and characterisation data for all compounds synthesised in Chapters 2, 3 and 4.

Keywords: organic chemistry
natural products
total synthesis
Advisor: Davies, S
The application of the Modigliani-Miller theorem to Japanese industry

The purpose of this thesis is to study some aspects of Japanese corporate finance, using the analytical tools of the Modigliani-Miller theorem.
The Modigliani Miller theorem is a fundamental element in the theory of finance, and establishes the conditions under which the financial structure of the firm is irrelevant to the determination of real corporate values. In its simplest form the theorem requires the presence of perfect capital markets. In the real world,- however, in which perfect capital markets dont exist the validity of the theorem depends upon a number of additional restrictions which can be viewed as special case extensions of the general form. One set of sufficient conditions ensuring the validity of the theorem, is obtained by imposing the assumption of riskless debt.
Large groups of major Japanese corporations can be characterized as operating virtually free of bankruptcy risk. The thesis attributes this to the Japanese system of values underlying economic relationships, to the system of corporate groupings (known as keiretsu), and to the strategic objectives of industrial policy which provide industry with a safety-net. It argues that the popular belief that Japanese industry is subject to excessive risk exposure because of its high degree of leverage is misleading. The belief arises from data based on accounting conventions which distort the true position of firms own wealth.
The thesis undertakes an empirical study of the validity of the MM theorem. Although the focus of the analysis is on the period 1978-80, the study is run on a second and very different time period, 1970-72. The major finding for the most recent period is that debt, after adjustment for tax advantages, makes no significant contribution to the valuation of companies in keiretsu groups. Interestingly, however, in the earlier period debt is found to make a positive and significant contribution to valuation.
The behaviour of jacked concrete pipes during site installation

While much money and effort has been spent by manufacturers and users of pipe jacking equipment to develop suitable techniques, this work appears to be the first to study the method at full scale, in a scientific research programme. It has involved monitoring a series of five pipe jacks during construction. In each case a heavily instrumented pipe was incorporated into the pipe string to measure pipe joint stresses, pipe and joint compressions and contact stresses between pipe and ground. Total jacking loads and movements of the pipe string were also measured and all results correlated with a detailed site log, full tunnel alignment surveys, and observed ground conditions. The success of the site monitoring has been highly dependent upon the development of a suitable instrumentation and data acquisition system in conjunction with appropriate site procedures for working in the restricted and physically demanding pipe jack environment without undue disruption to normal site operations. The build up of total jacking force is the result of highly complex soil-pipe interaction. The local interface stresses are essentially frictional in most ground conditions, and can be related to the shear strength of the ground. The problem is in determining the effective radial stresses which are affected by soil insitu stresses, stiffness and strength; groundwater conditions; rate of progress; pipeline misalignment and use of lubricants. Relations between pressure distributions at pipe joints and measured tunnel alignments are presented. That small angular deviations between successive pipes cause severe localisation of stresses on their ends is clearly demonstrated. Careful back analysis shows that the linear stress approach of the Concrete Pipe Association of Australia can adequately match the measured stresses and could be used by pipe manufacturers to provide design data on allowable jacking forces for pipes on the basis of pipe size, packer properties, concrete strength and angular alignment. It is also clear from the small pipe barrel stresses that improved packing materials would allow more of the potential strength of pipes to be achieved. Since relative angular than absolute deviations control transfer mechanisms between pipes, uncritical adherence to specifications based on absolute line and level is counter-productive.

Keywords: pipe jacking
Advisor: Milligan, G
Britain, America and the search for comprehensive naval limitation, 1927-1936

This thesis examines the regulation of naval competition between the major naval powers, and especially between Britain and the United States, under the regime of the Washington and London naval treaties, and the attempts to extend and maintain naval limitation in the period 1927 to 1936 in the face of Anglo-American rivalry and, later, the threats from Japan and Germany.
Based upon British and American public and private sources, it traces the interaction of the two nations, and their relationships with other naval powers, from 1927 - when Anglo-American relations reached a nadir after the failed 'Coolidge Conference' in Geneva and the subsequen abortive 'Anglo-French Compromise' - to 1936, when naval limitation ende but by which time Anglo-American antipathy was fading in the face of mut external threats. The naval conferences of Geneva (1927) and London (19 and 1935-36), and the parallel naval side of the long-running Disarmamen Conference and its Preparatory Commission are reviewed with their attend preparations in London and Washington, and the influence of domestic factors - public opinion, financial stringency, and personal and politic prejudice - are examined. The central role of the naval balance in the relationship between the interward Great Powers is stressed, and the importance of the naval negotiations to both governments and public opinion echoes our contemporary concern for the preservation and management of the strategic balance.
While the Washington-London naval system failed to halt naval rival it achieved the unforeseen consequences of permitting Britain to gracefu cede naval supremacy to the United States, under the guise of conceding 'parity', with a minimum of friction or indeed recognition of the fact. Additionally, it demonstrated by its breakdown the vulnerability of an arms limitation system that was neither geographically nor technically comprehensive.
Feedback in dwarf galaxies

Stellar feedback processes have been suggested as a mechanism for explaining various properties of galaxies, especially dwarf galaxies, which have weaker potentials and thus lower escape velocities for galactic winds. In this thesis, I present work done during my DPhil to better understand these processes. I begin by discussing the techniques used to simulate galaxies as collections of astrophysical fluids in a cosmolog- ical context, and present some methods for interpreting the results of such simulations. I then present two projects aimed at furthering our understanding of feedback in dwarf galaxies.
The first project is the investigation of a suite of simulations of satellites of a Milky Way-class halo. We discuss the formation of high-redshift dwarf galaxies and the effect that supernova feedback and reionisation have on the gas content and star formation history of these objects. We find that neither process has a dramatic effect on the star formation rates in high redshift dwarf galaxies that have already begun forming stars prior to reionisation. We do find, however, that the population of satellites is dramatically altered by the presence of cooled gas in the host halo, which increases the tidal stripping of satellites that pass close to the host. The second project concerns detailed simulations of a 15 solar mass star throughout its evolution, studying photoionisation, wind and supernova feedback from this star in various environments. Preliminary results are given for these simulations, which are compared to the results of previous authors.

Keywords: numerical astrophysics
galaxies
astrophysics
Advisor: Slyz, A
Competitive identity formation in the Turkish diaspora

This thesis examines the politics of narrative control, and how it relates to the formation of diasporic consciousness among Turkish migrants in the United States. It asks how Turkish diasporic identity is formed and shaped by discourses that frame Turks, and that interrogate who or what a ‘Turk’ is? This thesis suggests that this process of continual construction and re-construction of diasporic consciousness should be investigated as a matter of competitive identity formation, meaning that there is competition between multiple actors to impose a definition or label on a diasporic group and to achieve broad-based support for that label or definition. This also implies the attribution of specific values, ideas, and political agendas to that group.
The thesis examines the roots, motivations and activities of Turkish American activists in Washington DC. Based on an analysis of their political orientations and internal fissures, it focuses on the current political debate over official recognition of the deportations and massacres of Armenians by Ottoman forces as a genocide. It argues that Turkish American activists have coalesced on the defensive around this issue, framing it as a matter critical to the identity of Turks. Their manifold activities to prevent the further institutionalisation of the ‘genocide’ label in American political discourse do not, however, always resonate with the passive majority of Turkish Americans.

Keywords: Armenian genocide
Turkish-American
diasporic identity
Advisor: Cohen, R
de Haas, H
Molecular Genetics of Language Impairment

Developmental language impairments are neurodevelopmental disorders in which the acquisition of language, a task which children typically perform with ease, is hindered or fraught with difficulty. This work focuses on specific language impairment (SLI), a common and highly heritable language impairment in which language development is abnormal while other developmental domains are normal. Additionally, a case-study of a child with a broader linguistic and behavioural phenotype is also presented. The work described in this thesis includes both genetic and functional investigations which were aimed at identifying candidate genes for language impairment and provide insight into the genetic mechanisms that underlie language development.
I performed a genome-wide association study of SLI which included child genotype effects, maternal genotype effects, parent-of-origin effects, and maternal-foetal interaction effects. This study found significant paternal parent-of-origin effects with the gene NOP9 on chromosome 14, and suggestive maternal parent-of-origin effects with a region on chromosome 5 which had previously been implicated in autism and ADHD. Case-control and quantitative association analyses of HLA genes and SLI identified several risk alleles and protective alleles. A case-control association analysis for related individuals which used an isolated population affected by SLI identified a non-synonymous coding variant in the gene NFXL1 which was significantly more frequent in affected individuals than in unaffected individuals. High-throughput sequencing of the coding regions of NFXL1 and LD blocks surrounding associated variants in ATP2C2, CMIP and CNTNAP2 (as reported in previous studies) identified novel or rare non-synonymous coding variants in NFXL1 and ATP2C2 in SLI families as well as intronic variants in all four genes that were significantly more frequent in SLI probands than in population controls.
I describe a functional study of NFXL1 examining its expression in various brain regions, the presence of different splice variants across several tissues, its effect on genes it potentially interacts with, and the subcellular localisation of the protein.
Finally, I present the case-study of a child with language impairment who had chromosomal rearrangements which spanned the location of FOXP2. I examine the potential influence the chromosomal rearrangements had on FOXP2 expression and describe a lincRNA gene which was disrupted by the chromosomal inversion.
In conclusion, this work identified new candidate genes for language impairment, provided further support for the involvement of previously-identified candidate genes in SLI and contributed to the understanding of the molecular function of a newly-identified candidate gene for SLI.

Keywords: Communication Disorders
Genetics,Behavioral
Neurosciences
Genetics,Medical
Genetics
Advisor: Monaco, A
Newbury, D
Constituting the settler colony and reconstituting the indigene:- the native administration and constitutionalism of Sir George Grey K. C. B. during his two New Zealand governorships (1845-1853, 1861-68) until the outbreak of the Waikato War in 1863

Sir George Grey (1812-1898) served as Governor of South Australia, of New Zealand twice, and of the Cape Colony. This thesis explains his policy for the first time for a history of the political ideas of colonization. Grey introduced the policy of racial amalgamation to settler colonies after the 1837 Report of the Select Committee into Aboriginal Affairs, that had advised the policy of segregation as had been North American policy under Sir William Johnson. This thesis demonstrates that Grey was a Liberal Anglican who had adopted neo-Harringtonian thought, and who introduced Jeffersonian native policy into British native policy. He practised the strategic theory of Antoine-Henri Jomini, applying it to native policy. Grey captured the monarchical constitution of the empire for what had been a settler policy of dissent to the segregation of indigenes that dated back to Tudor Ireland and early Viginia. Grey's distinctive intellectual practices were ethnograpical research and speculation, for which he enjoyed an international reputation, and the constitutional design of settler colonies, an activity he came to totally identify with. The thesis concentrates on his first New Zealand governorship (1845-53) and upon the resumption of his second New Zealand governorship (1861-68) because it was in that colony he first fully practised his native policy and participated in constitutional design, and into which he brought about a crisis of indigenous amalgamation on the eve of the Waikato War in 1863, having introduced full responsible government.

Keywords: Harringtonianism
James Harrington (1611-1677)
South African history
British Imperial racial policy and administration
New Zealand history
Australian history
history of the British Empire
Sir George Grey K. C. B (1812-1898)
Advisor: Darwin, J