VictorJuiz/thesis huggingface dataset:
Three-dimensional geometric image analysis for interventional electrophysiology

Improving imaging hardware, computational power, and algorithmic design are driving advances in interventional medical imaging. We lay the groundwork here for more effective use of machine learning and image registration in clinical electrophysiology.
To achieve identification of atrial fibrosis using image data, we registered the electroanatomic map (EAM) data of atrial fibrillation (AF) patients undergoing pulmonary vein isolation (PVI) with MR (n = 16) or CT (n = 18) images. The relationship between image features and bipolar voltage was evaluated using single-parameter regression and random forest models. Random forest performed significantly better than regression, identifying fibrosis with area under the receiver operating characteristic curve (AUC) 0.746 (MR) and 0.977 (CT). This is the first evaluation of voltage prediction using image data.
Next, we compared the character of native atrial fibrosis with ablation scar in MR images. Fourteen AF patients undergoing repeat PVI were recruited. EAM data from their first PVI was registered to the MR images acquired before the first PVI (‘pre-operative’) and before the second PVI ('post-operative' with respect to the first PVI). Non-ablation map points had similar characteristics in the two images, while ablation points exhibited higher intensity and more heterogeneity in post-operative images. Ablation scar is more strongly enhancing and more heterogeneous than native fibrosis.
Finally, we addressed myocardial measurement in 3-D echocardiograms. The circular Hough transform was modified with a feature asymmetry filter, epicardial edges, and a search constraint. Manual and Hough measurements were compared in 5641 slices from 3-D images. The enhanced Hough algorithm was more accurate than the unmodified version (Dice coefficient 0.77 vs. 0.58). This method promises utility in segmentation-assisted cross-modality registration.
By improving the information that can be extracted from medical images and the ease with which that information can be accessed, this progress will contribute to the advancing integration of imaging in electrophysiology.

Keywords: random forest
cardiac ct
image analysis
cardiac mri
image segmentation
machine learning
cardiac electrophysiology
Advisor: Noble, J
Strategies in robust and stochastic model predictive control

The presence of uncertainty in model predictive control (MPC) has been accounted for using two types of approaches: robust MPC (RMPC) and stochastic MPC (SMPC). Ideal RMPC and SMPC formulations consider closed-loop optimal control problems whose exact solution, via dynamic programming, is intractable for most systems. Much effort then has been devoted to find good compromises between the degree of optimality and computational tractability. This thesis expands on this effort and presents robust and stochastic MPC strategies with reduced online computational requirements where the conservativeness incurred is made as small as conveniently possible.
Two RMPC strategies are proposed for linear systems under additive uncertainty. They are based on a recently proposed approach which uses a triangular prediction structure and a non-linear control policy. One strategy considers a transference of part of the computation of the control policy to an offline stage. The other strategy considers a modification of the prediction structure so that it has a striped structure and the disturbance compensation extends throughout an infinite horizon. An RMPC strategy for linear systems with additive and multiplicative uncertainty is also presented. It considers polytopic dynamics that are designed so as to maximize the volume of an invariant ellipsoid, and are used in a dual-mode prediction scheme where constraint satisfaction is ensured by an approach based on a variation of Farkas' Lemma.
Finally, two SMPC strategies for linear systems with additive uncertainty are presented, which use an affine-in-the-disturbances control policy with a striped structure. One strategy considers an offline sequential design of the gains of the control policy, while these are variables in the online optimization in the other.
Control theoretic properties, such as recursive feasibility and stability, are studied for all the proposed strategies. Numerical comparisons show that the proposed algorithms can provide a convenient compromise in terms of computational demands and control authority.

Keywords: optimization-based control
model predictive control
stochastic control
robust control
control policies
Advisor: Kouvaritakis, B
Cannon, M
Five modes of scepticism: an analysis of the Agrippan modes in Sextus Empiricus' outlines of Pyrrhonism

This thesis has as its focus five argumentative modes that lie at the heart of Sextus Empiricus’ Outlines of Pyrrhonism. They are the modes of disagreement, hypothesis, infinite regression, reciprocity and relativity. They are analysed, individually, in the first five chapters of the thesis (one mode per chapter) and, collectively, in the sixth. The first four chapters deal, respectively, with the modes of disagreement, hypothesis, infinite regression and reciprocity. They distinguish between two versions of these modes: “dogmatic versions”, on the basis of which a dogmatic philosopher, who holds some theoretical beliefs, might reach a sceptical conclusion; and “sceptical versions”, on the basis of which a sceptical philosopher, who lacks all theoretical beliefs, might do so. It is argued that scholars such as Jonathan Barnes have offered reconstructions of these modes which are dogmatic in the sense just described, and alternative sceptical versions of the modes are presented. A stand-alone fifth chapter offers an analysis of a stand-alone mode - the mode of relativity. It argues that there are in fact three different modes of relativity at play in the Outlines, that only one of them is non-trivial, and that the non-trivial version is incompatible with the mode of disagreement. The sixth and final chapter offers an analysis of how the modes (excluding relativity) are meant to work in combination with one another. Four different combinations are presented and it is argued that all of them are underscored by a variety of theoretical assumptions, which a sceptic, who lacks all theoretical beliefs, cannot make. The ultimate conclusion of the thesis is that, though the sceptic can deploy the various modes individually (by means of exercising his particular sceptical ability), he is not able to systematise them into a net by means of which he might trap his dogmatic opponent. Unless specified otherwise, translations are based on Annas, J., and Barnes, J., Sextus Empiricus: Outlines of Scepticism (Cambridge: Cambridge University Press, 2000).

Keywords: epistemology
Sextus Empiricus
Advisor: Charles, D
Mark Akenside and the poetry of current events

The aim of this thesis is to provide an analysis of the historical and political context of a group of poems which were written by Mark Akenside between 1738 and 1770. Most of these poems were composed in response to particular political events or situations, or to the publication of works of literature, history, or theology; the remainder are verse-epistles addressed to political figures who were personal friends of the poet. Arguments have also been included for the attribution to Akenside of a small number of anonymous poems.
I have taken a broadly chronological approach. The first chapter covers the period 1738-1739, and discusses the background and references of two poems written before and just after the declaration of the War of Jenkins' Ear. The subject of the second chapter is two poems addressed to the 'patriot' politician William Pulteney in 1742 and 1744 (before and after his supposed political apostasy). The third chapter considers the case for attribution of two short poems on the subject of the Jacobite Rebellion of 1745, and includes a discussion of an Ode addressed to the Earl of Huntingdon in 1747, In the fourth chapter, a poem composed during the contested Westminster election of 1749 is discussed, in addition to Odes addressed to Sir Francis-Henry Drake, Charles Townshend, and Dr Caleb Hardinge. The fifth chapter includes a consideration of Odes written on the occasion of the publication of three books: William Warburton's edition of Pope's works, Frederick the Great's Memoires,.., and Bishop Hoadly's Sermons; a second Ode to Drake is also discussed. The sixth chapter discusses another poem which relates to Warburton, an Ode on the poetry of the Abbe de Chaulieu, and a letter and an Ode on the subject of the Seven Years' War. The conclusion considers Akenside's revisions in the light of allegations that he abandoned his Whig principles and became a Tory towards the end of his life.
My object has been not only to elucidate obscure references and to supply contextual background information, but also to provide a picture of the political and intellectual history of the mid-eighteenth century as seen through the eyes of a highly intelligent, if politically partisan, observer.
Palaeoecology and sedimentology of Waulsortian 'reefs' (lower carboniferous)

Palaeoecological and sedimentological analysis has been applied in the study of Lower Carboniferous Waulsortian 'reefs' exposed in the Manifold Valley, North Staffordshire and in the Meuse Vallley in southern Belgium. Because Waulsortian 'reefs' have similar faunal, lithological and palaeogeographical characteristics in all of their occurrences it is argued that conclusions drawn from the Manifold and Meuse Valleys are applicable to the facies as a whole.
Evidence is presented to show that lithological facies previously recognised within the Belgian Waulsortian can also be recognised elsewhere, and that changing sedimentation rates can explain many of their characteristic differences. Faunal and seimentological evidence indicates that the rate of sedimentation increased as the mounds developed. It is argued that the mound sediment was produced in situ and faunal data suggests that the surface of the mounds was firm. Early submarine lithification is thought to have been an important process in producing firm substrates and in maintaining steep depositional slopes. Fabrics and lithological components suggestive of early lithification have been recognised.
A general model for Waulsortian development, based on conclusions drawn in this thesis, is presented.
The linguistics of orality: a psycholinguistic approach to private and public performance of classical Attic prose

The thesis tests the hypothesis that certain aspects of linguistic variation in Attic prose are related to the type of oral performance, private or public, which the author envisaged for his text. This hypothesis rests on the assumption that authors more or less consciously optimized their texts for their intended communicative situation. A crucial feature of texts optimized for public delivery was clarity, which figures as an essential component of the 'virtue of speech' in the Greek rhetorical thought. In private situations the audience itself could alter the pace of reading or recitation. Clarifications could be sought, and pauses and repetitions would be possible. The case was different with public situations, where the text itself coincided with its performance and it was entirely up to the speaker to determine the way in which the audience would access it. Especially in political and judicial contexts, where important decisions were to be made, public speakers could not afford being unclear.
In order to test whether public texts were clearer than private texts, 'clarity' must be defined in a linguistically thorough way. Modern psycholinguistics studies human language comprehension, and experimental research has revealed language-independent mechanisms which can be confidently applied to dead languages. In the thesis, clarity is measured by the number of syntactic, semantic, and referential reanalyses which linguistics structures induce in a given amount of text.
This methodology is tested on a corpus of Attic speeches, which includes both texts that were devised exclusively for written circulation and private delivery, and texts that were at least conceived for public delivery, although we do not know to what extent they correspond to the versions which were actually delivered. The difference between the average score of 'public texts' and that of 'private texts' is statistically significant and supports the hypothesis that 'public texts' were generally clearer than 'private texts' for audiences of native speakers.

Keywords: oral performance
psycholinguistics
Greek rhetoric
Attic oratory
Advisor: Willi, A
Compatible domain structures in ferroelectric single crystals

The aim of the current study is to develop an efficient model which can predict low-energy compatible microstructures in ferroelectric bulks and film devices and their dynamic behaviour. The results are expected to assist in the interpretation of microstructure observations and provide a knowledge of the possible domain arrangements that can be used to design future materials with optimum performance.
Several recent models of ferroelectric crystals assume low energy domain configurations. They are mainly based on the idea of fine phase mixtures and average compatibility, and can require intensive computation resulting in complex domain configurations which rarely occur in nature. In this research, criteria for the exact compatibility of domain structure in the form of a periodic multi-rank laminate are developed. Exactly compatible structure is expected to be energetically favourable and does not require the concept of a fine mixture to eliminate incompatibilities. The resulting method is a rapid and systematic procedure for finding exactly compatible microstructures. This is then used to explore minimum rank compatible microstructure in various crystal systems and devices. The results reveal routes in polarization and strain spaces along which microstructure can continuously evolve, including poling paths for ferro- electric single crystals. Also, the method is capable to generate all possible exactly compatible laminate configurations for given boundary conditions. It is found that simple configurations are often energetically favourable in conditions where previous approaches would predict more complex domain patterns. Laminate domain patterns in ferroelectrics are classified and corre- lated with observations of domains in single crystals, showing good agreement.
The evolution of microstructures under applied mechanical and electrical loads is studied. A variational method, which minimises the overall energy of the crystal is developed. A new concept of transitional “pivot states” is introduced which allows the model to capture the feature that the microstructure in ferroelectric crystal switches between possible domain patterns that are energetically favourable, rather than assuming one particular domain pattern throughout. This model is applied to study the hysteresis responses of barium titanate (BaTiO3) single crystals subjected to a variety of loads. The results have good agreement with experimental data in the literature. The relationship between domain patterns and ferroelectric hysteresis responses is discussed.

Keywords: compatibility
ferroelectric
microstructure
Advisor: Huber, J
Application of magnetic torque on the bacterial flagellar motor

There is a strong need to develop a mechanical method to apply external torque to the bacterial flagellar motor. Such a method will allow us to probe the behaviour of the motor at a range of different speeds under different external conditions.
In this thesis, I explored various methods to deliver torque at the single-molecule level, in particular the use of angular optical trapping and magnetic tweezers. I have identified rutile particles as suitable handles for use in angular optical trapping due to their high birefringence. Further progress was not achieved using angular optical trapping due to the lack of a suitable method to attach birefringent particles to the bacterial flagellar motor. On the other hand, I was able to make further progress using magnetic tweezers. A highly-reproducible and high-yielding magnetic bead assay was developed along with electromagnets capable of generating fast-rotating magnetic fields at magnitudes on the order of tens of mT.
Using the system of delivering magnetic torque developed, I was able to stall and rotate the motor forward at speeds up to 220 Hz and in the reverse direction. Stalling experiments carried out on the motor revealed the stator mechanosensing depends on torque and not rotation. Signatures of stators dropping out at low load experiments further confirm the load dependence of stators.

Keywords: bacterial flagellar motor
Single-molecule biophysics
electromagnetic tweezers
Advisor: Berry, R
Soviet policy in West Africa, 1957-64

Between 1957 and 1964 the Soviet Union sought to export to West Africa a model of economic and social development. Moscow’s policy was driven by the conviction that socialism was a superior economic system, and could be replicated in Ghana, Guinea, and Mali. However, Soviet confidence in the project was undermined by the unreliability of local leaders, and then by the Congo crisis. The setback in West Africa taught the Soviet leadership crucial lessons, including the importance of supporting ideologically reliable leaders, and the necessity of building military strength to bolster intervention. Combining Soviet and Ghanaian sources with those more readily available in the UK and the US, this thesis shows the importance of modernisation of the Third World for Moscow’s foreign policy during the Khrushchev era, and contributes to the new sets of literature on the cold war in the third world, and on the Soviet Union’s foreign policy.

Keywords: Soviet Union
Cold War
Africa
Advisor: Anne, D
Alex, P
Psychiatry’s 'golden age': making sense of mental health care in Uganda, 1894-1972 

This thesis investigates the emergence of an internationally renowned psychiatric community in Uganda. Starting at the beginning of colonial rule in 1894, it traces the changing nature of mental health care both within and beyond the state, examining the conditions that allowed psychiatry to develop as a significant intellectual tradition in the years following Independence in 1962. This ‘golden age’ of psychiatry saw Uganda establish itself as a leader of mental health care in Africa, an aspect of history that is all the more marked for its contrast with the almost complete collapse of mental health care after the expulsion of the Asian population by Idi Amin in 1972. Using a wide range of new source material, including interviews with psychiatrists, traditional healers, and community elders, this thesis pushes the history of psychiatry in Africa beyond the examination of government policy and colonial hegemony. It brings together the history of psychiatry with the histories of missionary medicine, medical education, and international health by asking what types of people, institutions, and organisations were involved in the provision of mental health care; how important the growth of Makerere Medical School was for intellectual and institutional psychiatry; and how African mental health care had become by the end of the period. It presents a history of mental health care in a country that has tended to be overshadowed by Kenya in the historiography, yet whose engagement with medical missionaries and efforts to advance medical training meant that the trajectory of psychiatry came to be quite different. Focusing in particular on the significance of western-trained Ugandan medical practitioners for mental health care, the thesis not only analyses African psychiatrists as historical actors in their own right, but represents the first attempt to examine the development of psychiatric education in Africa.

Keywords: missionaries
mental health
Uganda
Africa
psychiatry
education
Advisor: Mahone, S
Charity and poor relief in a context of poverty

Colombia in the second half of the nineteenth century was a country with extensive poverty and vulnerability was the main characteristic of the poor. A general concern about the conditions of the poor, particularly in urban areas, was broadly manifested. Poverty was seen basically as a moral problem, and poor relief was implemented within a process of moralization.
Between 1870 and 1930 poor relief underwent significant transformation: it grew appreciably, became more complex, more dynamic, more professional and more specialized; it passed gradually from being strongly localized to a departmental and national orientation. Poor relief involved the decision from the state to incorporate the 'social' in the government agenda and by 1930 started to be more grounded in political reality. An identifiably modern 'social policy' came into being, even though it contained some ambiguities and traditional values.
There were two main forms of poor relief: institutional and outdoor. Institutional poor relief was predominantly carried out by the state and some private societies. Some state poor relief establishments continued to be run by religious orders. Outdoor poor relief was only implemented by private societies and institutions.
For poor relief public beneficencia and private charity were equally important. In this period the state attempted to consolidate resources for beneficencia and for social assistance; it created specific poor relief taxes and established special funds. Private giving was linked to traditional Christian charity. Charity was constant, large and participants covered a broad social spectrum. Modern ideas of charity were progressively introduced, generating a professionalization of voluntary activities. Alongside poor relief there were other survival strategies promoted by the poor of which mutual aid societies were the best example. They grew considerably and they gave support to their members in an any eventualities. They were certainly important in the formation of'social capital'.
Sources for this research are dispersed; most of them came from institutions, societies, establishments that carried out poor relief activities. Research about poor relief generally and inevitably has to face a lack of informal data on many aspects of the subject, though much can be gained through the study of wills.

Advisor: Deas, M
The practical accomplishment of novelty in the UK patent system

Novelty is a widespread notion that has not been given commensurate critical attention. This research is an ethnographically-inclined exploration of practices surrounding the accomplishment of novelty in an institution for which novelty is a central notion: the patent system of the United Kingdom. The research is based on interviews with patent examiners at the UK patent office, interviews with patent attorneys at various legal firms, and documentary analysis of legislation and numerous legal judgments. The thesis brings to bear themes from Science and Technology Studies and ethnomethodology to assess the extent to which they can account for the practices surrounding novelty in the UK patent system. As a fundamental legal requirement for the patentability of inventions, novelty is a central part of the practices of patent composition, assessment and contestation. Rather than being a straightforward technical criterion, however, novelty is shown to be a complex and heterogeneous phenomenon emerging from interwoven legal, bureaucratic and individual practices. The local resolution of whether or not a given invention is new, and the cross-institutional coherence of novelty as a practicable notion, raise questions concerning ontology, accountability, scale and inconcludability, and provide an opportunity for empirically grounded engagement with these longstanding analytical concerns.

Keywords: sociology of knowledge
intellectual property
patents
science &amp; technology studies
Advisor: Woolgar, S