VictorJuiz/thesis huggingface dataset:
An holistic approach to optimal ultra-wideband wireless communications system design

Ultra-wideband (UWB) wireless systems rely on signals spanning very wide bandwidths, typically several gigahertz, for information transmission. The distinguishing feature of UWB communications technology is the unrivalled data-rates it provides, with other benefits such as fade resistance and spectral reusability. These characteristics render UWB the technology of choice for a gamut of modern wireless communications applications, including multimedia transmission, personal- and body-area networks, imaging devices, and sensor networks. The use of wide bandwidth signals, however, leads to many complications that necessitate specialised design considerations. The propagation channel and system components acquire frequency-selective characteristics, and their nonlinear and dispersive nature, usually innocuous in a conventional setting, causes signal distortion and erroneous detection. This thesis analyses various aspects of the indoor channel and the distortion to a UWB signal propagating through it. The performance of transmitter and receiver sub-systems is evaluated, with an emphasis on the challenges posed by the large operating bandwidth. The significance of incorporating this knowledge into the system design process is demonstrated, and a novel framework for optimising the performance-complexity tradeoff is presented.
• The following are the contributions of this thesis to the state of the art in UWB communications.
• Experimental characterisation of the indoor UWB channel spanning the FCC band (3.1-10.6 GHz)
• Demonstration of the variability of propagation characteristics in the spectral sub-bands
• Assessment of frequency-dependent pathless and the consequent signal waveform distortion
• Polarimetric analysis of the temporal, spectral and angular channel evolution
• Evaluation of rake receiver performance and its dependence on various channel conditions
• Investigation of the effect of antenna angular-spectral distortion on signal propagation
• A technique for the normalisation of UWB link aberration due to antennas
• Performance evaluation of diversity and spatial multiplexing with multiple-antenna systems
• Design of gigabit wireless links for high data-rate applications or high user density scenarios
• A novel holistic framework for the design of an optimal UWB communications system

Advisor: Edwards, D
Utrophin upregulation and microRNAs - two avenues of Duchenne muscular dystrophy therapy research

Characterized by the severe progressive wastage of skeletal muscle, Duchenne muscular dystrophy (DMD) is a crippling X-linked recessive disease that is caused by the absence of the protein dystrophin. This thesis aimed to critically evaluate the potential of different therapeutic options to combat this disease. Utrophin is a paralogue of dystrophin. The Fiona mouse is an mdx (dystrophin-deficient) transgenic mouse that overexpresses the full-length utrophin protein in skeletal muscle, and various studies have shown that it does not display a dystrophic phenotype. However, these studies have only been performed on sedentary mice. In this work it is demonstrated that utrophin’s protective effect is partially diminished after a sustained period of exercise-induced stress, highlighting for the first time a functional difference between dystrophin and utrophin. This thesis also presents results of two mdx mouse drug trials testing the ameliorative effects of the administration of the drugs GW501516 and C1100, which show that treatment with both drugs results in partial amelioration of the dystrophic phenotype. GW501516 administration results in a beneficial fast-to-slow fibre type switch and an in vivo increase in utrophin protein levels. We have also shown that C1100 treatment results in a significant increase in utrophin A promoter activity in vitro, and the mechanism of action of this drug on this promoter has been deciphered. The global dysregulation of microRNAs in skeletal muscle of mdx and dko (dystrophin- and utrophin-deficient) mice was evaluated by microarray analysis to identify microRNAs involved in the dystrophic pathological cascades. The results of detailed expression analyses of miR-31, miR-206 and miR-503 are presented, and two therapeutically-relevant predicted targets of miR-503 were validated. Overall, this thesis evaluates the potential of different and possibly complementary therapeutic options to combat DMD.

Keywords: DMD
utrophin
myopathy
microRNA
Duchenne
miRNA
Advisor: Davies, K
Transnationalism and the Internet: the case of London-based Chinese professionals

This thesis examines the role of internet use in migrants’ participation in, and articulation of, rising Chinese modernity. It explores the ways in which transnational subjectivity is produced through this process. It investigates how migrants’ various uses of the internet construct and make sense of their connections with China. It demonstrates a new generation of subjectivity among Chinese transnationals that is tech-savvy, modern and triumphal – a subjectivity embedded in the exchange between the (macro) political economy of China’s rise and the (micro) everyday practices surrounding the internet.
This is an ethnographic study focusing on an emerging population within the broader Chinese diaspora; that is, mainland Chinese professionals who migrated for higher education and professional training in recent years as a result of China’s reform and economic power. This study locates its enquiries in three offline-grounded institutions – ethnic organisations, states and families. These institutions pre-date the internet but increasingly turn to the technology for transnational and local connections.
Regarding Chinese organisations, utilising the internet to build co-ethnic sociality is read as a symbolic practice that signals the users’ belonging to a technologically-advanced, mobile and wealthy sector within the broader idea of the Chinese community. On the role of the state, internet use provides new modes of migrants’ access to China’s state-led development projects, thus opening up new spaces for the state’s disciplinary power to be exercised. This digital governance is enabled by a discourse of Chinese triumphalism constructed by both the state and the migrants. Regarding families, the digitalisation of the gendered division of labour in transnational families provides evidence of the segmented nature of China’s digital modernity and disrupts the triumphal portrait of transnational modernity constructed among the elite-stratum migrants.
Overall, this study develops a dialogue between two literatures. On the one hand, it adds to diasporic internet studies by introducing an offline-grounded, geographically-informed approach and by bringing transnational modernity into its research agenda. On the other hand, it draws on Nonini and Ong’s (1997) theorisation of Chinese transnationalism as alternative modernity and further adds to this theorisation with a focus on internet technology and a discussion of the impacts of China’s rise. It contributes to human geography by revisiting a key concept in this discipline – transnationalism – with a discussion of the interweaving impacts of information technology and the geopolitical shift of China’s rising modernity.

Keywords: China
migration
transnationalism
Internet
Advisor: Rogers, A
Currah, A
Bringing the party back in: mobilization and persuasion in constituency election campaigns

In this thesis, I report the results from the first randomized field experiments conducted in collaboration with party-affiliated candidates and campaigns in the United Kingdom. The papers presented as part of this thesis test both the limits and possibilities of campaign influence, in a partisan political environment. During election campaigns parties provide signals to voters, voluntarily or involuntarily imposing a structure, and thereby constraints, on individuals’ electoral decisions. By integrating insights about heuristic and social decision-making into the experimental campaign literature, I formulate testable hypotheses about the direct and indirect effects of party cues on campaign mobilization and persuasion.
The first paper, The Heuristic Function of Party Affiliation in Voter Mobilization Campaigns, addresses how the provision of party cues, used during campaign phone calls, affects turnout among party supporters, opponents and unattached voters. The second paper on Household Partisan Composition and Voter Mobilization, explores the spillover effects from the previous experiment, testing whether campaign-induced mobilization between household members is conditioned by the partisan composition of a household, and the partisan intensity of a campaign message. Paper three investigates if candidates who are Reaching Across The Partisan Divide can win over supporters of rival parties. In the fourth paper, I test if Impersonal, But Noticeable methods of voter contact, such as door hangers and text messages, affect the turnout decisions of partisans and unattached voters. The final paper, The National Effects of Subnational Representation, highlights the importance of local party organization for the outcomes of national elections. The results of this thesis show the electoral consequences of direct and indirect interactions between campaigns and voters of different partisanship, and point to strategies that allow constituency campaigns to successfully navigate challenging partisan environments.

Keywords: household
party
persuasion
Labour
mobilisation
campaign
randomised field experiment
turnout
elections
Advisor: Fisher, S
Evans, G
Ambiguous and ambivalent signatures

While existing criticism of Emma Tennant's work emphasizes its feminist agenda, less attention has been paid to her rewriting of different narratives and discourses. Tennant's career has centered on challenging literary values as well as generic categories, realist conventions, and gender stereotypes. Contrary to implications that rewriting is "re-vision," an "act of survival" that corrects or subverts earlier texts, this thesis argues that Tennant's characteristic resistance to categories also extends to the work of rewriting and revision. Her texts suggest that the act of "writing back" is not as straightforward as it may seem, but deeply ambiguous and ambivalent.
Developing theories of the "signature" that return the writer-as-agent to the otherwise anonymous field of intertextuality, this thesis traces Tennant's figurations of writing, metafictional devices, and intertextual allusions to show how these relate to themes in the fiction. Examining groupings of the texts from different critical perspectives, each chapter shows how Tennant's rewritings destabilize notions of originality, identity, and agency, and represent political discourses and social progress in an ambivalent way. While this thesis offers very specific insights into Tennant's work, the close readings also encompass broader themes, such as feminism and postmodernism, the gothic, myths of home and exile, and the ventriloquistic techniques of pastiche and biofiction. The arguments centered on her work contribute to the larger discourse on rewriting in two ways. First, in problematizing assumptions that rewriting inherently strives toward progress or correction, this thesis argues that rewriting can dramatize the ambiguity and ambivalence that haunt acts of resistance. Second, in advancing challenges to the idea that intertextuality functions anonymously, it argues that rewriting can return agency to the text by offering representations of authorship that engage with literary and cultural history.

Advisor: Byrne, S
Shakespeare and a cult of solitude

The argument of the thesis is that there was a gradual change in attitudes towards solitude during the sixteenth century, which reached its most extreme towards the end of the century, giving rise to a cult of solitude. These attitudes, and the cult itself, became a crucial formative element in the work of Shakespeare.
Part One describes the evidence for and motivations behind the search for solitude, and considers the history of ideas on solitude, placing the climactic period, between about 1570 and 1630, within the context of earlier and later ideology. Writers of the period are shown to have used the solitude debate as a vehicle for more abstract ideas about the duty to self and to society, individual preference and communal morality, and the inward and the presented self. Whereas the social ideal valued the individual as part of a greater whole, the solitary ideal saw him as an absolute in himself, defined from within. The persistence of medieval habits of thought alongside new sixteenth-century perspectives resulted in an omnipresent dualism, a balancing of opposites based on an unwillingness for unequivocal commitment to either extreme.
Part Two demonstrates the centrality pf this preoccupation with solitude and the definition of the self in Shakespeare's work, comparing and contrasting the development of his ideas with that of his contemporaries. The thesis considers Shakespeare's sympathies, moral judgements r and ideals through the changing perspectives on the solitary from play to play, Despite his sensitivity to the deepest levels of the contemporary cult of solitude, Shakespeare finally keeps faith with the essentially medieval ideal of the social bond. Solitude, for him, fails as an ideal, and is acceptable only where the social ideal is irreparably corrupted.
Mutational analysis of isoform selectivity and conformational equilibria in protein kinase inhibition

Deregulation of protein kinases is associated with many diseases making them important targets for therapeutic intervention. Kinases can switch between active and inactive conformations that can be targeted by type 1 or type 2 inhibitors respectively. One of the most relevant conformational switches is the ‘in’ and ‘out’ movement of the ATP/Mg2+ binding motif DFG. Factors modulating the conformational equilibria such as the residue environment of regulatory motifs remain poorly understood despite their importance for drug discovery.
In this thesis, the first model system tested the hypothesis that accessibility of the DFG-out conformation is restricted by the energetic cost of transition between the in and out states. CDK2 was chosen as a target that was thought to have an inaccessible DFG-out conformation, and several point mutations were introduced to promote this conformational transition. Detailed biochemical and biophysical characterisation illustrated that the mutants bound type 2 inhibitors more potently than the wild type. In addition, the wild-type CDK2 was shown to bind type 2 inhibitors in the absence, but not in the presence, of cyclin. The first known CDK2 co-crystal structure in the DFG-out conformation was solved, opening the door to a new class of CDK2 inhibitors.
In the second project, site-directed mutagenesis was used to explore the residues determining inhibitor selectivity between PIM1 and PIM2. Evaluation of ligand binding to the variants and comparison of PIM1 and PIM2 crystal structures showed that flexibility of the phosphate-binding loop was the dominant factor determining the differences in their affinities for ATP and small molecule inhibitors. These studies illustrate that residues contributing to kinase conformational equilibria can be just as important for inhibitor binding as contact residues formed in the ligand complex.

Keywords: CDK2
kinase
conformations
inhibitors
cancer
mutants
selectivity
Advisor: Knapp, S
Deane, C
Jacob, S
Moebitz, H
Laser cooling and trapping of atoms

A detailed experimental and theoretical investigation of a magneto-optical trap for caesium atoms is presented. Particular emphasis has been placed on achieving high spatial number densities and low temperatures. Optimizing both of these together enables efficient evaporative cooling from a conservative trap, a procedure which has recently led to the first observations of Bose-Einstein condensation in a dilute atomic vapour.
The behaviour of a magneto-optical trap is nominally determined by four independent parameters: the detuning and intensity of the light field, the magnetic field gradient and the number of trapped atoms. A model is presented which incorporates previous treatments into a single description of the trap that encompasses a wide range of its behaviour. This model was tested quantitatively by measuring the temperature of the cloud and its spatial distribution as a function of the four parameters. The maximum density was found to be limited both by the reabsorption of photons scattered within the cloud and by a reduction of the confining force at small light shifts. The nonlinear variation with position of the restoring force was found to be significant in limiting the number of atoms confined to a high density. A maximum density in phase space (defined as the number of atoms in a box with sides of dimension one thermal de Broglie wavelength) of (1.5 ± 0.5) x 10-5 was observed, with a spatial density of 1.5 x 1011 atoms per cm3.
Cold collision losses from a caesium magneto-optical trap have been studied with the purpose of assessing their influence on spatial densities. In contrast to previous measurements of similar quantities, these measurements did not require the use of an ultra-low (< 10-10 Torr) background vapour pressure. The dependence of the cold collision loss coefficient β on the trapping intensity was measured to permit identification of the different cold collision processes. The largest loss rates observed were those due to hyperfine structure-changing collisions, with a coefficient β = (2±1) x 10-10cm3s-1.
A study is presented of a modified magneto-optical trap in which a fraction of the population is shelved into a hyperfine level that does not interact with the trapping light. In this so-called "dark" magneto-optical trap, improved densities of nearly 1012cm-3 have been previously reported for sodium. The application of the technique to caesium is not straightforward due to the larger excited state hyperfine splittings. A simple theory for caesium is presented and its main predictions verified by measurements of density, number and temperature. A density of nearly 1012cm,-3 was indeed obtained but at a temperature substantially higher than in the conventional magneto-optical trap.
The Athenian dramatic chorus in the fourth century BC

This thesis tackles a conspicuous absence in current scholarship on ancient theatre. Amid the recent scholarly interest in the rapid expansion of the theatre industry from the late fifth-century BC onwards, no study has been made of a central, defining even, element of ancient Greek drama at that time – the chorus. Instead, what we find is a widespread assumption concerning the fourth-century dramatic chorus, particularly with regard to the comic chorus, still prevalent in today’s scholarship: ‘The history of the dramatic chorus is one of decline both quantitatively and qualitatively’, states one of the more detailed recent reviews of the evidence for dramatic choral culture in the ancient world (Csapo and Slater 1995:349).
The thesis focuses on the literary sources available to us concerning fourth-century dramatic choruses in Athens. The material is divided into three sections. The first section addresses the important testimony of Aristotle concerning the choruses of his day, particularly in the Poetics (chapter one). The second section analyses the choral text in the (probably fourth-century) Rhesus (chapter two), the interpolated choral passages in the Iphigenia at Aulis and Seven Against Thebes (chapter three), and the choruses of Aristophanes’ Assemblywomen and Wealth, as well as extant fragments of fourth-century comedy (chapter four). The third section is a survey of how the chorus is used in a wide range of fourth-century texts (chapter five), and gives special attention to Plato’s somewhat idiosyncratic presentation of the chorus in his works (chapter six). These analyses show 1) that ‘decline’ is an inappropriate term to describe the development of the chorus and 2) the creativity with which the chorus is used and thought about in fourth-century drama and society. The thesis aims to provide an elucidation of dramatic choral activity in the fourth century and to provoke further interrogation of the assumptions commonly held about the development of both the ancient chorus and ancient drama as a whole.

Keywords: fourth century
decline
tragedy
chorus
Ancient Greek theatre
comedy
Advisor: Budelmann, F
Rehabilitation in cerebral palsy evaluation of physiotherapy intervention after multi-level orthopaedic surgery

Complex orthopaedic surgery is often indicated in the management of deformity in children with spastic diplegic cerebral palsy (CP) and a long rehabilitation programme is important for a successful outcome. However, the frequency and content of physiotherapy treatment following surgery varies between centres. This thesis aimed at providing a scientific basis for post-operative rehabilitation following multi-level surgery in children with CP.
The effect of muscle weakness on function in patients with CP is recognised. However, the short and long-term impact of multi-level orthopaedic surgery on muscle strength is unclear. Strength changes would have implications for both surgical and conservative treatment planning. The objectives of this study were to establish a better understanding of the impact of surgery on muscle strength, gait and function, as well as the natural history of weakness in CP. Furthermore, the study aimed to clarify whether physiotherapy, focused on resistance strengthening techniques, was more effective than routine physiotherapy.
The reliability of a protocol for measuring muscle strength in lower limb muscle groups in this population was firstly established. A pilot study of 10 children with a diagnosis of spastic diplegic CP and healthy counterparts demonstrated a reliable strength testing protocol. The main study of 20 diplegic children who underwent multi-level surgery showed that despite improvements in gait parameters, significant loss of strength in lower limb muscle groups and gross motor function persisted at six months. The value of intensive physiotherapy was assessed in a randomised controlled trial six months after surgery. Advantages of resistance training over active exercise were demonstrated. Assessment at one year showed that surgical patients preserved the post-physiotherapy strength and function gains but these did not reach the pre-operative values. Another group of 10 diplegic children who received routine physiotherapy but no surgical treatment for 12 months showed significant deterioration of their gait.
The rate of deterioration demonstrated in conservatively treated diplegic patients and the degree of weakness caused by surgery, should inform parents and clinicians during decisions regarding surgery. Future research in multi-level surgery should include specific strength assessment protocols. The results from the randomised clinical trial showed that overall intensive strengthening regimes after multi-level surgery are beneficial. This finding would have significant implications on managing resources and designing appropriate rehabilitation programmes after multi-level orthopaedic surgery.

Advisor: Theologis, T
Thompson, N