VictorJuiz/thesis huggingface dataset:
Curriculum tracking and the achievement ideology at an American urban public school

This thesis presents a case study of how curriculum differentiation operates at Lincoln High School, an urban public school in the Midwestern United States with a highly regarded International Baccalaureate (IB) program. I use a mix of qualitative and quantitative methods to investigate the systems of beliefs and practices that structure Lincoln's tracking system.
Like many American high schools, Lincoln has rejected the traditional practice of assigning all students to overarching curriculum 'tracks' on the basis of their measured aptitude, instead allowing students to choose between courses covering different content at different levels of difficulty in most academic subjects. The school thus offers an excellent opportunity to examine within-school stratification in light of the declining popularity of traditional tracking and the increasing degree to which students control their own coursetaking. Within-school stratification is particularly worthy of continued attention because it qualifies the mythology of the American dream, which holds that schools give students from all backgrounds an opportunity to achieve upward social mobility. I use interviews, observations, and document analysis to explore how curriculum differentiation structures academic and social hierarchies at Lincoln, what teachers and students believe about how to achieve school success and upward mobility, and how Lincoln reconciles its egalitarian ideals with the continued existence of de facto tracking.
I argue that Lincoln's approach to curriculum differentiation strikes a tenuous balance between academic excellence and equity for all students. Although student choice dominates the course scheduling process, Lincoln's curriculum still bears many of the hallmarks of tracking: the IB structures a clear academic and social hierarchy of courses, and students tend to follow predictable patterns of coursetaking within each subject, with few opportunities for upward mobility. Nonetheless, teachers and students almost unanimously subscribe to the local achievement ideology, which holds that any student, regardless of prior academic achievement, can and should participate in the IB as long as he or she is willing to work hard. This radical promise of equal opportunity allows participants to characterize Lincoln as a force for equality and social justice. However, the school's continued reliance on sorting its students, even in the face of evidence that tracking reproduces racial and class inequalities, suggests that the achievement ideology serves primarily to legitimate stratification, not to undo it. These findings have important ramifications for research in tracking, detracking, and stratification, and for practice in all schools seeking to negotiate the tension between excellence and equity.

Keywords: achievement ideology
curriculum tracking
meritocracy
International Baccalaureate
Advisor: Phillips, D
Structure and function of bacterial ion channels

KirBac channels are prokaryotic homologs of eukaryotic inwardly-rectifying potassium channels, which have served as models for gaining insight into the structure of eukaryotic channels. This thesis focuses on the structure-function relationship in these channels. The first part of this study concerns a novel KirBac channel, KirBac9.2, which contains a unique amino acid sequence in the place of the canonical GYG selectivity filter. Although expressed and purified in a stable and functional form, the protein did not form well-diffracting crystals. Functional studies suggest that KirBac9.2 is non-selective for monovalent cations and a random mutagenesis screen identified a number of activatory mutants in the cytoplasmic domains of the channel. A full electrophysiological investigation of KirBac9.2 channel function is beyond the scope of this study. However, initial studies suggest that it is possible to record currents from KirBac9.2 channels reconstituted into lipid bilayers. The second part of this thesis investigates KirBac3.1, which is a classical KirBac channel containing the consensus GYG sequence for potassium selectivity. Five high resolution structures of a mutant channel are reported, which suggest a new feature in the gating mechanism of KirBac3.1 where a rotation of the cytoplasmic domains is linked to a change in the electrostatic environment of the cytoplasmic cavity. In addition, a functional study of the KirBac3.1 showed that the channel is highly pH sensitive.

Keywords: Kir channels
KirBac channels
structure-function
Ion channels
Advisor: Tucker, SJ
The lives of Ovid: secrets, exile and galanterie in writing of the ‘Grand Siècle’  

This study examines the constructions and uses of the figure of Ovid in French writing of the second half of the seventeenth century, and explores how they were modulated by contemporary aesthetic and cultural concerns. As the influence of Ovid’s poetry made itself felt in various ways – in the mythopoeia of the Sun-King and the fashionable galant salons – interest in the story of Ovid’s life blossomed. This, I argue, was facilitated by new forms of ‘life-writing’, the nouvelle historique and histoire galante, and fuelled in unexpected ways by the escalating querelle des Anciens et des Modernes. Research has been done on the reception and influence of Ovid’s poetry in this period, but little attention has been paid to the figure of Ovid. This thesis offers a new perspective and, informed by recent renewed interest in life-writing, argues that analysis of biographical depictions is vital for establishing a coherent picture of the uses of Ovid in the ‘Grand Siècle’.
I explore a diverse range of textual descriptions of Ovid (Vies; prefatory material attached to translations and editions of his work; correspondence; dialogues des morts; biographical dictionaries and historical novels), organized according to their different, though intersecting, ways of writing about this poet. He was constructed as a historical figure, an author, a fictional character and a ‘parallèle’ – a point of identification or contrast for contemporary writers. Through close analysis of a multi-authored corpus, this thesis identifies and examines two instances of paradox: though an ancient poet, Ovid became emblematic of 'Moderne' movements and was used to explore aspects of galanterie; and, though his creative work was mobilized in the service of royal propaganda, Ovid, as a figure for the exiled poet, was also used to express anxieties about the sway of power and the machinations and pitfalls of the world of the court.

Keywords: Life-writing
Madame de Villedieu
Galanterie
History and Criticism
Pierre Bayle and Historiography
La Querelle des Anciens et des Modernes
Ovid
Bussy-Rabutin.
Classical Reception
17th-Century French Literature
Anne de la Roche-Guilhen
Advisor: Tunstall, K
Effects of age on sleep and consolidation of motor learning

Background: Our ability to consolidate what we learn changes with age. However, little is known about the neurophysiological underpinnings of consolidation of motor learning in ageing. This is largely because studies have repeatedly demonstrated a deficit in sleep-dependent consolidation of motor learning in older adults. This thesis aims to reassess commonly held assumptions about consolidation in ageing, as well as to examine the neurophysiological and neurochemical mechanisms that support the learning and consolidation processes.
Methods: Most of the studies in this thesis are based on the design of a novel whole-hand task for use in older adults, which reduces dependency on fine motor skill. This thesis adopts a number of converging measures to examine learning and memory including electroencephalograhy (EEG), magnetic resonance spectroscopy (MRS), actigraphy recordings, as well as behavioural and self-reported measures of sleep.
Results: Findings show significant improvements in learning with the adapted motor task in older adults. Importantly, this task reveals significant sleep- dependent enhancements in older adults, which are comparable to those seen in younger controls. Functional changes in sleep architecture with ageing show overall decline in slow wave sleep. Sleep-dependent improvements were specifically associated with activity in stage 3 slow wave sleep and increased hemispheric differences regardless of age. Changes in GABA concentrations with learning on a visuomotor tracking task showed marked variability across participants, and no clear associations were found between GABA and consolidation.
Conclusion: The evidence presented in this thesis highlight the complex dynamics underlying sleep consolidation, and challenges a commonly held assumption about consolidation in older adults. Specifically, the studies presented here show that observed declines in motor consolidation with ageing may be contaminated by age-related deficits fine motor skill. By removing such kinematic constraints, it was possible to detect marked improvements in motor performance also in older adults despite age-related changes in sleep architecture.

Keywords: consolidation
memory
learning
sleep
ageing
Advisor: Johansen-Berg, H
Wulff, K
Factionalism in the French Parti Socialiste, 1971-1981

This thesis concentrates on the cause, structure, location and context (rather than the function) of factions within the French Parti Socialiste, from the Congress of Epinay, in June 1971, until Mitterrand's election as Socialist President of the Republic, on May 10th, 1981. It argues that factionalism results from a complex, interrelated cleavage structure: groups are differentiated according to a number of salient variables, of which the most important are personality (accentuated by the presidentialised Fifth Republic); ideology/policy; strategy/tactics; organisational interests and different historical origins. Factional relations are a product both of the intra-party consequences of the party's external objectives, and the internal dynamic created by factional competition itself. The party is thus an evolutive, rather than a static entity.
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Design and analysis of genome-wide association studies

Despite many years of effort, linkage and candidate gene association studies have yielded disappointingly few risk loci for common human diseases such as diabetes, auto-immune disorders and cancers. Large sample sizes, increased understanding of the patterns of correlation in genetic variation, and plunging genotyping costs have enabled genome-wide association studies, which have good power to detect common risk alleles of modest effect. I present an evaluation of SNP choice in study design and show that overall, despite substantial differences in genotyping technologies, marker selection strategies and number of markers assayed, the first generation platforms all offer good levels of genome coverage (∼ 70%). I next describe the largest such project undertaken to date, the Wellcome Trust Case Control Consortium, which consisted of 2000 cases from each of seven common diseases and 3000 shared controls. It identified nearly two dozen new associations. I demonstrate the importance of careful data quality control, including both standard and unorthodox analyses. I next focus on the association results therein for Crohn’s disease. I present a replication experiment in over 1000 additional Crohn’s patients which unambiguously confirmed six previously published loci and four new loci. Next I describe, in a general context, several issues impeding the combination of genome-wide scans, including data annotation, population structure and differences in genotyping platform. Each of these problems is shown to be tractable with available methods, provided that these methods are applied prudently. I present the results of a meta-analysis of three genome-wide scans for Crohn’s disease. The data showed a striking excess of significant associations, and a replication experiment involving over 4000 independent Crohn’s patients verified twenty new risk loci. Finally, I discuss the early success of genome-wide association and its consequences for further understanding the biology of human disease.

Keywords: crohn's disease
genome-wide association study
Advisor: Donnelly, P
Cardon, L
A study of the phenotype and function of HLA-C restricted CD8 T cells in HIV-1 infection

A recent study showed that a polymorphism ~35kb upstream of the HLA-C gene (-35 SNP) correlates with host control of HIV-1 in Caucasians, with the minor allele (C) associating with significantly lower set point viral loads than the major allele (T). A link between viral load and HLA-C is suggested by linkage of the two SNP alleles with different HLA-C alleles and by the fact that HLA-C, in contrast to HLA-A and -B, is not down-regulated by HIV-1 Nef protein. In addition, the -35C variant has been shown to associate with higher HLA-C messenger RNA expression in EBV-transformed B cell lines. We initially propose that increased surface expression of HLA-C in subjects with the protective SNP leads to increased breadth and magnitude of HLA-C restricted T cell responses, explaining the decrease in viral load in these subjects.
This study initially investigates whether the -35 SNP correlates with the surface level of HLA-C using the monoclonal antibodies DT9, which recognises both HLA-C and HLA-E, and 3D12, which is specific for HLA-E. The lymphocytes from -35 CC subjects expressed a significantly higher level of surface HLA-C when compared to those from -35 TT subjects, but this difference in HLA-C expression can be attributed primarily to the very low expression of a single allelic product, HLA-Cw*07.
Increased surface HLA-C should translate to functional differences between CC and TT subjects. This study confirmed that HLA-C restricted CD8 T cell responses against HIV-1 do exist, even for HLA-Cw*07, but represent a minority of total T cell responses. They were detected in all -35 SNP genotypes but there were no functional differences, making it unlikely that the protective effect of this SNP on viral load set point could be accounted for solely by HLA-C restricted T cell responses.
Finally, a viral suppression assay was used to investigate the capacity of CD8 T cells to suppress HIV-1 replication in Caucasian and African subjects. We provide evidence that the -35 SNP effect on viral load is indeed T cell mediated. However, we suggest that the protective effect of the -35 SNP on viral load set point manifests as a result of linkage disequilibrium of this polymorphism with both favourable and unfavourable HLA-B and HLA-C alleles.

Keywords: HIV-1
HLA-C
Advisor: McMichael, A
Chemical and biological studies on human oxygenases

As depicted in Chapter I, 2-oxoglutarate- (2OG) dependent oxygenases are ubiquitous in living systems and display a wide range of cellular functions, spanning metabolism, transcription, and translation. Although functionally diverse, the 2OG oxygenases share a high degree of structural similarities between their catalytic sites. From a medicinal chemistry point of view, the combination of biological diversity and structural similarity presents a rather challenging task for the development of selective small molecules for functional studies in vivo.
The non-selective metal chelator 8-hydroxyquinoline (8HQ) was used as a template for the generation of tool compound I for the KDM4 subfamily of histone demethylases via application of the Betti reaction. Structural analogue II was used as the corresponding negative control (Figure A). These compounds were characterised in vitro against a range of 2OG oxygenases and subsequently used for studies in cells. I displays selectivity for KDM4 and increases the level of the H3K9me3 histone mark in cells. It has an effect on the post-translational modification pattern of histone H3, but not other histones, and reduces the viability of lung cancer cells, but not normal lung cells, derived from the same patient. I also stabilises hypoxia-inducable factor HIF in cells via a mechanism which seems to be independent from prolyl hydroxylase inhibition. This work is described in Chapters II and III.
The chemical biology research in epigenetics is complemented by qualitative analysis conducted in the social sciences at Said Business School. With a global view on how innovation occurs and may actively be fostered, Chapter IV focuses on the potential of epigenetics in drug discovery and how this process may actively be promoted within the framework of open innovation. Areas of focus include considerations of incremental and disruptive technology; how to claim, demarcate, and control the market; how knowledge brokering occurs; and insights about process, management, organisation, and culture of open innovation.
In contrast to the open-skies approach adopted for the development of a tool compound in Chapters II and III, a focused-library approach was taken for the generation of a tool compound for the OGFOD1 ribosomal prolyl hydroxylase. The development of a suitable in vitro activity assay for OGFOD1 in Chapter V enabled the development of lead compound III in Chapter VI. III is selective for OGFOD1 against the structurally closely related prolyl hydroxylase PHD2.

Keywords: platform
2-oxoglutarate
prostate
demethylase
breast
non-haem
muscular dystrophy
chemical probe
KDM
translation
technology
cystic fibrosis
open
organasational capability
ribosome
collaboration
innovation
market
cancer
transcription
lung
OGFOD1
histone
epigenetics
iron
2OG
oxygenase
Advisor: Schofield, C
Quantum information theory and the foundations of quantum mechanics

This thesis is a contribution to the debate on the implications of quantum information theory for the foundational problems of quantum mechanics. In Part I an attempt is made to shed some light on the nature of information and quantum information theory. It is emphasized that the everyday notion of information is to be firmly distinguished from the technical notions arising in information theory; however it is maintained that in both settings ‘information’ functions as an abstract noun, hence does not refer to a particular or substance. The popular claim ‘Information is Physical’ is assessed and it is argued that this proposition faces a destructive dilemma. Accordingly, the slogan may not be understood as an ontological claim, but at best, as a methodological one. A novel argument is provided against Dretske’s (1981) attempt to base a semantic notion of information on ideas from information theory. The function of various measures of information content for quantum systems is explored and the applicability of the Shannon information in the quantum context maintained against the challenge of Brukner and Zeilinger (2001). The phenomenon of quantum teleportation is then explored as a case study serving to emphasize the value of recognising the logical status of ‘information’ as an abstract noun: it is argued that the conceptual puzzles often associated with this phenomenon result from the familiar error of hypostatizing an abstract noun. The approach of Deutsch and Hayden (2000) to the questions of locality and information flow in entangled quantum systems is assessed. It is suggested that the approach suffers from an equivocation between a conservative and an ontological reading; and the differing implications of each is examined. Some results are presented on the characterization of entanglement in the Deutsch-Hayden formalism. Part I closes with a discussion of some philosophical aspects of quantum computation. In particular, it is argued against Deutsch that the Church-Turing hypothesis is not underwritten by a physical principle, the Turing Principle. Some general morals are drawn concerning the nature of quantum information theory. In Part II, attention turns to the question of the implications of quantum information theory for our understanding of the meaning of the quantum formalism. Following some preliminary remarks, two particular information-theoretic approaches to the foundations of quantum mechanics are assessed in detail. It is argued that Zeilinger’s (1999) Foundational Principle is unsuccessful as a foundational principle for quantum mechanics. The information-theoretic characterization theorem of Clifton, Bub and Halvorson (2003) is assessed more favourably, but the generality of the approach is questioned and it is argued that the implications of the theorem for the traditional foundational problems in quantum mechanics remains obscure.

Keywords: quantum information theory
quantum mechanics
quantum computation
Advisor: Brown, H
Analogy between equilibrium of structures and compatibility of mechanisms

Planar bar-and-joint mechanisms with one degree-of-freedom are widely used in deployable structures and machines. Such mechanisms are designed to undergo a specific motion, which can be described mathematically by plotting out the compatibility conditions, resulting in a curve called compatibility path. It has been observed that compatibility paths can develop singularities similar to that of equilibrium paths of elastic structures. This dissertation studies singularities occurring in compatibility paths with the aid of knowledge in the theory of structural stability. An analogy is set up between the equilibrium path of elastic structures and the compatibility path of mechanisms with a single degree-of-freedom incorporating the different types of bifurcation, effects of imperfections and detection of singularities. It is shown that the fundamentally distinct critical points such as limit points and bifurcation points can also appear in compatibility path. Methods used to singularities for compatibility conditions of mechanisms and equilibrium of structures are unified so that they can be used for both cases. A formulation of potential energy for mechanisms is also proposed in analogy with the potential energy function used in structural analysis. Further analysis of the mechanisms is carried out to demonstrate that singularities of compatibility paths can also be dealt with by the elementary catastrophe theory similar to the stability theory. A relationship is established between the mathematical formulation of different compatibility bifurcations and the canonical forms of catastrophe types. Examples of mechanisms demonstrating the existence of cuspoids of the compatibility conditions are given. An overall classification of the compatibility paths is also proposed.

Keywords: deployable structures
Advisor: You, Z